Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001472-TA|BGIBMGA001472-PA|IPR004842|Na-K-Cl
cotransporter superfamily, IPR002443|Na-K-Cl co-transporter,
IPR004841|Amino acid permease-associated region
(1036 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
U30246-1|AAC50561.1| 1212|Homo sapiens bumetanide-sensitive Na-K... 597 e-170
BC033003-1|AAH33003.1| 1150|Homo sapiens SLC12A2 protein protein. 597 e-170
AY280459-1|AAP33906.1| 1212|Homo sapiens bumetanide-sensitive Na... 597 e-170
U58130-1|AAB07364.1| 1099|Homo sapiens bumetanide-sensitive Na-K... 590 e-168
U44128-1|AAC50355.1| 1030|Homo sapiens thiazide-sensitive Na-Cl ... 537 e-152
X91220-1|CAA62613.1| 1021|Homo sapiens NaCl electroneutral Thiaz... 530 e-150
BC040138-1|AAH40138.1| 430|Homo sapiens SLC12A1 protein protein. 260 2e-68
BC126160-1|AAI26161.1| 714|Homo sapiens solute carrier family 1... 165 7e-40
BC126158-1|AAI26159.1| 714|Homo sapiens solute carrier family 1... 165 7e-40
AF390442-1|AAM73657.1| 731|Homo sapiens solute carrier family 1... 165 7e-40
AF345197-1|AAO49174.1| 714|Homo sapiens cation-chloride cotrans... 165 7e-40
AF312032-7|AAK21009.1| 627|Homo sapiens cation-chloride cotrans... 162 7e-39
AF312032-6|AAK21008.1| 914|Homo sapiens cation-chloride cotrans... 162 7e-39
BC051744-1|AAH51744.1| 943|Homo sapiens SLC12A6 protein protein. 161 9e-39
AB033284-1|BAB40456.1| 914|Homo sapiens cation chloride cotrans... 161 1e-38
AF284422-1|AAF88060.1| 914|Homo sapiens cation-chloride cotrans... 161 2e-38
AF439152-1|AAL32454.1| 311|Homo sapiens sodium-potassium-chlori... 148 1e-34
AK129998-1|BAC85271.1| 342|Homo sapiens protein ( Homo sapiens ... 144 1e-33
U55054-1|AAC50563.1| 1085|Homo sapiens K-Cl cotransporter protein. 139 5e-32
BC132670-1|AAI32671.1| 1116|Homo sapiens solute carrier family 1... 139 5e-32
BC132668-1|AAI32669.1| 1116|Homo sapiens solute carrier family 1... 139 5e-32
BC021193-1|AAH21193.1| 1085|Homo sapiens solute carrier family 1... 139 5e-32
AL162458-7|CAH74054.2| 1116|Homo sapiens solute carrier family 1... 139 5e-32
AF208159-1|AAG43493.1| 1116|Homo sapiens electroneutral potassiu... 139 5e-32
AF054506-1|AAC39685.1| 1068|Homo sapiens erythroid K:Cl cotransp... 139 5e-32
AF054505-1|AAC39684.1| 1011|Homo sapiens erythroid K:Cl cotransp... 139 5e-32
AF047338-1|AAC32815.1| 1085|Homo sapiens erythroid K:Cl cotransp... 139 5e-32
AB033002-1|BAA86490.1| 1101|Homo sapiens KIAA1176 protein protein. 139 5e-32
DQ138323-1|ABA02873.1| 1141|Homo sapiens potassium chloride cotr... 134 2e-30
BC126243-1|AAI26244.1| 1099|Homo sapiens solute carrier family 1... 134 2e-30
BC126241-1|AAI26242.1| 1099|Homo sapiens solute carrier family 1... 134 2e-30
BC070107-1|AAH70107.2| 1091|Homo sapiens solute carrier family 1... 134 2e-30
AL117500-1|CAB55965.1| 1014|Homo sapiens hypothetical protein pr... 134 2e-30
AF531260-1|AAQ10028.1| 1091|Homo sapiens K-Cl cotransporter KCC3... 134 2e-30
AF531259-1|AAQ10027.1| 1091|Homo sapiens K-Cl cotransporter KCC3... 134 2e-30
AF531258-1|AAQ10026.1| 1135|Homo sapiens K-Cl cotransporter KCC3... 134 2e-30
AF477977-1|AAL85335.1| 1011|Homo sapiens K-Cl cotransporter KCC3... 134 2e-30
AF314956-2|AAM96216.1| 1099|Homo sapiens potassium-chloride tran... 134 2e-30
AF314956-1|AAM96215.1| 1150|Homo sapiens potassium-chloride tran... 134 2e-30
AF116242-1|AAF24986.1| 1150|Homo sapiens K-Cl cotransporter KCC3... 134 2e-30
AF108831-1|AAD25337.1| 1099|Homo sapiens K:Cl cotransporter 3 pr... 134 2e-30
AF105366-1|AAD39742.1| 1150|Homo sapiens K-Cl cotransporter KCC3... 134 2e-30
BC098390-1|AAH98390.1| 1083|Homo sapiens solute carrier family 1... 132 6e-30
AK024497-1|BAB15787.1| 721|Homo sapiens FLJ00105 protein protein. 132 6e-30
AK024493-1|BAB15783.1| 780|Homo sapiens FLJ00098 protein protein. 132 6e-30
AF105365-1|AAD39741.1| 1083|Homo sapiens K-Cl cotransporter KCC4... 132 6e-30
AL162458-6|CAH74053.1| 285|Homo sapiens solute carrier family 1... 115 8e-25
BC007760-1|AAH07760.1| 266|Homo sapiens SLC12A7 protein protein. 110 2e-23
AK024494-1|BAB15784.1| 672|Homo sapiens FLJ00100 protein protein. 109 7e-23
AK024421-1|BAB15711.1| 772|Homo sapiens FLJ00010 protein protein. 109 7e-23
AF389851-1|AAK94307.1| 584|Homo sapiens solute carrier family 1... 96 7e-19
BC000154-1|AAH00154.1| 538|Homo sapiens SLC12A9 protein protein. 94 3e-18
AK090458-1|BAC03439.1| 487|Homo sapiens FLJ00379 protein protein. 92 1e-17
AK024420-1|BAB15710.1| 540|Homo sapiens FLJ00009 protein protein. 92 1e-17
AB209192-1|BAD92429.1| 122|Homo sapiens solute carrier family 1... 81 2e-14
AK024466-1|BAB15756.1| 477|Homo sapiens FLJ00059 protein protein. 73 7e-12
AF053402-1|AAC35282.1| 238|Homo sapiens erythrocyte K-Cl cotran... 50 4e-05
BX538023-1|CAD97969.1| 525|Homo sapiens hypothetical protein pr... 49 8e-05
AL117433-1|CAB55921.1| 186|Homo sapiens hypothetical protein pr... 46 0.001
CR457363-1|CAG33644.1| 308|Homo sapiens SLC12A8 protein. 41 0.020
BC020506-1|AAH20506.1| 308|Homo sapiens SLC12A8 protein protein. 41 0.020
AK026841-1|BAB15571.1| 308|Homo sapiens protein ( Homo sapiens ... 41 0.020
AJ005333-1|CAA06480.1| 31|Homo sapiens Na-K-2Cl cotransporter ... 41 0.026
AB032527-1|BAA84576.1| 31|Homo sapiens Na-K-2Cl cotransporter ... 41 0.026
BC063528-1|AAH63528.1| 338|Homo sapiens SLC12A8 protein protein. 39 0.080
BC012087-1|AAH12087.1| 501|Homo sapiens solute carrier family 7... 38 0.25
AJ277882-1|CAC81905.1| 501|Homo sapiens cystine/glutamate trans... 38 0.25
AF252872-1|AAK49111.1| 501|Homo sapiens cystine/glutamate trans... 38 0.25
AF200708-1|AAG35592.1| 501|Homo sapiens calcium channel blocker... 38 0.25
AB040875-1|BAB40574.1| 494|Homo sapiens cystine/glutamate excha... 38 0.25
AB026891-1|BAA82628.1| 501|Homo sapiens cystine/glutamate trans... 38 0.25
X59155-1|CAA41869.1| 629|Homo sapiens retroviral receptor protein. 35 1.7
X57303-1|CAA40560.1| 629|Homo sapiens REC1L protein. 35 1.7
BC115407-1|AAI15408.1| 629|Homo sapiens solute carrier family 7... 35 1.7
BC069358-1|AAH69358.1| 629|Homo sapiens solute carrier family 7... 35 1.7
BC063303-1|AAH63303.1| 629|Homo sapiens solute carrier family 7... 35 1.7
AL596114-3|CAI39913.1| 629|Homo sapiens solute carrier family 7... 35 1.7
AF078107-1|AAC27721.1| 629|Homo sapiens cationic amino acid tra... 35 1.7
AJ005332-1|CAA06479.1| 31|Homo sapiens Na-K-2Cl cotransporter ... 33 7.0
AB032525-1|BAA84574.1| 31|Homo sapiens Na-K-2Cl cotransporter ... 33 7.0
>U30246-1|AAC50561.1| 1212|Homo sapiens bumetanide-sensitive Na-K-Cl
cotransporter protein.
Length = 1212
Score = 597 bits (1473), Expect = e-170
Identities = 298/649 (45%), Positives = 415/649 (63%), Gaps = 18/649 (2%)
Query: 100 EGVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVK 159
+GVL+ C+LNIWGVMLF+R+SW+V QAGIG S+++I ++ VV IT LS SAI TNG V+
Sbjct: 289 KGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVR 348
Query: 160 GGGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFCDSMNHLLKSLDLQIIDNSYN 219
GGG YY+ISRSLGPEFG ++G+IFAFANAVA +M +GF +++ LLK + +ID N
Sbjct: 349 GGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMIDE-IN 407
Query: 220 DVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAVMGPKSNLEVAEGF 279
D+RIIGAI + ++ I GM+WE+KAQ L+ I++ AI DFV+G + +S + +GF
Sbjct: 408 DIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAIGDFVIGTFIPLES--KKPKGF 465
Query: 280 VGLSTSTFVENFNSDFKYSEGMEQNFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKG 339
G + F ENF DF+ E+ FFSVFAIFFP+ TGI AGANISGDL DP SAIPKG
Sbjct: 466 FGYKSEIFNENFGPDFRE----EETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKG 521
Query: 340 TLLALLISMVSYAMMVLFTGAAALRDASGNITDLVISNGTVTNYSAV------SQCANST 393
TLLA+LI+ + Y + + G+ +RDA+GN+ D +++ T +A S C +S
Sbjct: 522 TLLAILITTLVYVGIAVSVGSCVVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESS- 580
Query: 394 LFPCKYGMHVDFEIMQLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGL 453
PC YG+ +F++M ++S + P I AG + P++ QAL D IYP
Sbjct: 581 --PCSYGLMNNFQVMSMVSGFTPLISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAF 638
Query: 454 IFFSKPYGRHGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAAL 513
F+K YG++ E RGY IA+LN IAP+ISNF+LASYALINF FHA+L
Sbjct: 639 QMFAKGYGKNNEPLRGYILTFLIALGFILIAELNVIAPIISNFFLASYALINFSVFHASL 698
Query: 514 VRPLGWRPTFKYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNW 573
+ GWRP FKYYN+W+SL G ++C +M +I+W +L+T I LY+ V Y+ PDVNW
Sbjct: 699 AKSPGWRPAFKYYNMWISLLGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNW 758
Query: 574 GSSTQAQMYKTALSSAHNLARTGEHVKNYWPQLLVLGGRAHARPPLVDLGSLITKAGSLM 633
GSSTQA Y AL + L+ +HVKN+ PQ LV+ G ++RP L+ L TK LM
Sbjct: 759 GSSTQALTYLNALQHSIRLSGVEDHVKNFRPQCLVMTGAPNSRPALLHLVHDFTKNVGLM 818
Query: 634 IIGDI--SKEKLSYKVCSARARADNEWLQERKVRAFCSLVHGFNFEQGARALIQATGVGK 691
I G + + + K S WL + K++AF + VH + +GA+ L+QA G+G+
Sbjct: 819 ICGHVHMGPRRQAMKEMSIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGR 878
Query: 692 LAPNVLLMGYKSDWTTASAEDLVAYFNVLHTAFENRLAVAIVRVRGGLD 740
+ PN L++G+K DW A D+ Y N+ H AF+ + V ++R++ GLD
Sbjct: 879 MKPNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQYGVVVIRLKEGLD 927
Score = 170 bits (413), Expect = 3e-41
Identities = 87/199 (43%), Positives = 120/199 (60%), Gaps = 13/199 (6%)
Query: 850 FKRKQESGTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIFXXXXXXXXXXXXXXXXX 909
F++KQ T+DVWWL+DD GLT+L+PY+++ + W +CK+R+F
Sbjct: 1015 FQKKQGKNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKINRIDHDRRAMAT 1074
Query: 910 XXXSKFRIDYSSLTMVQDITEPPQAETKALFDETIKKFTSDSAAPE------------CR 957
SKFRID+S + ++ DI P+ E F+E I+ + E R
Sbjct: 1075 LL-SKFRIDFSDIMVLGDINTKPKKENIIAFEEIIEPYRLHEDDKEQDIADKMKEDEPWR 1133
Query: 958 ISETELTTLSGKTNRQLRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMSRD 1017
I++ EL KT RQ+RL ELL +S + +IVMSLP+ RKG+VS+ LYMAWLE +S+D
Sbjct: 1134 ITDNELELYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKD 1193
Query: 1018 LPPMLFVRGNHTSVLTFYS 1036
LPP+L VRGNH SVLTFYS
Sbjct: 1194 LPPILLVRGNHQSVLTFYS 1212
>BC033003-1|AAH33003.1| 1150|Homo sapiens SLC12A2 protein protein.
Length = 1150
Score = 597 bits (1473), Expect = e-170
Identities = 298/649 (45%), Positives = 415/649 (63%), Gaps = 18/649 (2%)
Query: 100 EGVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVK 159
+GVL+ C+LNIWGVMLF+R+SW+V QAGIG S+++I ++ VV IT LS SAI TNG V+
Sbjct: 289 KGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVR 348
Query: 160 GGGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFCDSMNHLLKSLDLQIIDNSYN 219
GGG YY+ISRSLGPEFG ++G+IFAFANAVA +M +GF +++ LLK + +ID N
Sbjct: 349 GGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMIDE-IN 407
Query: 220 DVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAVMGPKSNLEVAEGF 279
D+RIIGAI + ++ I GM+WE+KAQ L+ I++ AI DFV+G + +S + +GF
Sbjct: 408 DIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAIGDFVIGTFIPLES--KKPKGF 465
Query: 280 VGLSTSTFVENFNSDFKYSEGMEQNFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKG 339
G + F ENF DF+ E+ FFSVFAIFFP+ TGI AGANISGDL DP SAIPKG
Sbjct: 466 FGYKSEIFNENFGPDFRE----EETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKG 521
Query: 340 TLLALLISMVSYAMMVLFTGAAALRDASGNITDLVISNGTVTNYSAV------SQCANST 393
TLLA+LI+ + Y + + G+ +RDA+GN+ D +++ T +A S C +S
Sbjct: 522 TLLAILITTLVYVGIAVSVGSCVVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESS- 580
Query: 394 LFPCKYGMHVDFEIMQLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGL 453
PC YG+ +F++M ++S + P I AG + P++ QAL D IYP
Sbjct: 581 --PCSYGLMNNFQVMSMVSGFTPLISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAF 638
Query: 454 IFFSKPYGRHGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAAL 513
F+K YG++ E RGY IA+LN IAP+ISNF+LASYALINF FHA+L
Sbjct: 639 QMFAKGYGKNNEPLRGYILTFLIALGFILIAELNVIAPIISNFFLASYALINFSVFHASL 698
Query: 514 VRPLGWRPTFKYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNW 573
+ GWRP FKYYN+W+SL G ++C +M +I+W +L+T I LY+ V Y+ PDVNW
Sbjct: 699 AKSPGWRPAFKYYNMWISLLGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNW 758
Query: 574 GSSTQAQMYKTALSSAHNLARTGEHVKNYWPQLLVLGGRAHARPPLVDLGSLITKAGSLM 633
GSSTQA Y AL + L+ +HVKN+ PQ LV+ G ++RP L+ L TK LM
Sbjct: 759 GSSTQALTYLNALQHSIRLSGVEDHVKNFRPQCLVMTGAPNSRPALLHLVHDFTKNVGLM 818
Query: 634 IIGDI--SKEKLSYKVCSARARADNEWLQERKVRAFCSLVHGFNFEQGARALIQATGVGK 691
I G + + + K S WL + K++AF + VH + +GA+ L+QA G+G+
Sbjct: 819 ICGHVHMGPRRQAMKEMSIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGR 878
Query: 692 LAPNVLLMGYKSDWTTASAEDLVAYFNVLHTAFENRLAVAIVRVRGGLD 740
+ PN L++G+K DW A D+ Y N+ H AF+ + V ++R++ GLD
Sbjct: 879 MKPNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQYGVVVIRLKEGLD 927
Score = 84.6 bits (200), Expect = 2e-15
Identities = 36/98 (36%), Positives = 57/98 (58%), Gaps = 1/98 (1%)
Query: 850 FKRKQESGTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIFXXXXXXXXXXXXXXXXX 909
F++KQ T+DVWWL+DD GLT+L+PY+++ + W +CK+R+F
Sbjct: 1015 FQKKQGKNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVF-IGGKINRIDHDRRAMA 1073
Query: 910 XXXSKFRIDYSSLTMVQDITEPPQAETKALFDETIKKF 947
SKFRID+S + ++ DI P+ E F+E I+ +
Sbjct: 1074 TLLSKFRIDFSDIMVLGDINTKPKKENIIAFEEIIEPY 1111
>AY280459-1|AAP33906.1| 1212|Homo sapiens bumetanide-sensitive
Na-K-Cl cotransporter protein.
Length = 1212
Score = 597 bits (1473), Expect = e-170
Identities = 298/649 (45%), Positives = 415/649 (63%), Gaps = 18/649 (2%)
Query: 100 EGVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVK 159
+GVL+ C+LNIWGVMLF+R+SW+V QAGIG S+++I ++ VV IT LS SAI TNG V+
Sbjct: 289 KGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVR 348
Query: 160 GGGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFCDSMNHLLKSLDLQIIDNSYN 219
GGG YY+ISRSLGPEFG ++G+IFAFANAVA +M +GF +++ LLK + +ID N
Sbjct: 349 GGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMIDE-IN 407
Query: 220 DVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAVMGPKSNLEVAEGF 279
D+RIIGAI + ++ I GM+WE+KAQ L+ I++ AI DFV+G + +S + +GF
Sbjct: 408 DIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAIGDFVIGTFIPLES--KKPKGF 465
Query: 280 VGLSTSTFVENFNSDFKYSEGMEQNFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKG 339
G + F ENF DF+ E+ FFSVFAIFFP+ TGI AGANISGDL DP SAIPKG
Sbjct: 466 FGYKSEIFNENFGPDFRE----EETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKG 521
Query: 340 TLLALLISMVSYAMMVLFTGAAALRDASGNITDLVISNGTVTNYSAV------SQCANST 393
TLLA+LI+ + Y + + G+ +RDA+GN+ D +++ T +A S C +S
Sbjct: 522 TLLAILITTLVYVGIAVSVGSCVVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESS- 580
Query: 394 LFPCKYGMHVDFEIMQLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGL 453
PC YG+ +F++M ++S + P I AG + P++ QAL D IYP
Sbjct: 581 --PCSYGLMNNFQVMSMVSGFTPLISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAF 638
Query: 454 IFFSKPYGRHGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAAL 513
F+K YG++ E RGY IA+LN IAP+ISNF+LASYALINF FHA+L
Sbjct: 639 QMFAKGYGKNNEPLRGYILTFLIALGFILIAELNVIAPIISNFFLASYALINFSVFHASL 698
Query: 514 VRPLGWRPTFKYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNW 573
+ GWRP FKYYN+W+SL G ++C +M +I+W +L+T I LY+ V Y+ PDVNW
Sbjct: 699 AKSPGWRPAFKYYNMWISLLGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNW 758
Query: 574 GSSTQAQMYKTALSSAHNLARTGEHVKNYWPQLLVLGGRAHARPPLVDLGSLITKAGSLM 633
GSSTQA Y AL + L+ +HVKN+ PQ LV+ G ++RP L+ L TK LM
Sbjct: 759 GSSTQALTYLNALQHSIRLSGVEDHVKNFRPQCLVMTGAPNSRPALLHLVHDFTKNVGLM 818
Query: 634 IIGDI--SKEKLSYKVCSARARADNEWLQERKVRAFCSLVHGFNFEQGARALIQATGVGK 691
I G + + + K S WL + K++AF + VH + +GA+ L+QA G+G+
Sbjct: 819 ICGHVHMGPRRQAMKEMSIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGR 878
Query: 692 LAPNVLLMGYKSDWTTASAEDLVAYFNVLHTAFENRLAVAIVRVRGGLD 740
+ PN L++G+K DW A D+ Y N+ H AF+ + V ++R++ GLD
Sbjct: 879 MKPNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQYGVVVIRLKEGLD 927
Score = 170 bits (413), Expect = 3e-41
Identities = 87/199 (43%), Positives = 120/199 (60%), Gaps = 13/199 (6%)
Query: 850 FKRKQESGTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIFXXXXXXXXXXXXXXXXX 909
F++KQ T+DVWWL+DD GLT+L+PY+++ + W +CK+R+F
Sbjct: 1015 FQKKQGKNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKINRIDHDRRAMAT 1074
Query: 910 XXXSKFRIDYSSLTMVQDITEPPQAETKALFDETIKKFTSDSAAPE------------CR 957
SKFRID+S + ++ DI P+ E F+E I+ + E R
Sbjct: 1075 LL-SKFRIDFSDIMVLGDINTKPKKENIIAFEEIIEPYRLHEDDKEQDIADKMKEDEPWR 1133
Query: 958 ISETELTTLSGKTNRQLRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMSRD 1017
I++ EL KT RQ+RL ELL +S + +IVMSLP+ RKG+VS+ LYMAWLE +S+D
Sbjct: 1134 ITDNELELYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKD 1193
Query: 1018 LPPMLFVRGNHTSVLTFYS 1036
LPP+L VRGNH SVLTFYS
Sbjct: 1194 LPPILLVRGNHQSVLTFYS 1212
>U58130-1|AAB07364.1| 1099|Homo sapiens bumetanide-sensitive
Na-K-2Cl cotransporter protein.
Length = 1099
Score = 590 bits (1458), Expect = e-168
Identities = 295/650 (45%), Positives = 411/650 (63%), Gaps = 19/650 (2%)
Query: 100 EGVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVK 159
+GVL+ C+LNIWGVMLF+R+SW+V +AGIG ++II LS +V IT +S SAI TNG V+
Sbjct: 181 KGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVIIIGLSTIVTTITGMSTSAIATNGVVR 240
Query: 160 GGGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFCDSMNHLLKSLDLQIIDNSYN 219
GGG YY+ISRSLGPEFG S+G+IFAFANAVA +M +GF +++ LLK D ++D + N
Sbjct: 241 GGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVDPT-N 299
Query: 220 DVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAVMGPKSNLEVAEGF 279
D+RIIG+I + ++ I GM+WE+KAQ L+ I++ AI +F +G V+ P +N + + GF
Sbjct: 300 DIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVI-PSNNEKKSRGF 358
Query: 280 VGLSTSTFVENFNSDFKYSEGMEQNFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKG 339
S F ENF F EG FFSVFAIFFP+ TGI AGANISGDL+DP AIP+G
Sbjct: 359 FNYQASIFAENFGPRFTKGEG----FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRG 414
Query: 340 TLLALLISMVSYAMMVLFTGAAALRDASGNITDLVISNGTVTNYSAV-------SQCANS 392
T+LA+ I+ V+Y + + GA +RDA+GN+ D +IS G N SA S+C +
Sbjct: 415 TMLAIFITTVAYLGVAICVGACVVRDATGNMNDTIIS-GMNCNGSAACGLGYDFSRCRHE 473
Query: 393 TLFPCKYGMHVDFEIMQLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVDRIYPG 452
PC+YG+ +F++M ++S +GP I AG + P++ QAL D IY
Sbjct: 474 ---PCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKA 530
Query: 453 LIFFSKPYGRHGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAA 512
L FF+K YG++ E RGY IA+LN IAP+ISNF+LASYALINF FHA+
Sbjct: 531 LQFFAKGYGKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHAS 590
Query: 513 LVRPLGWRPTFKYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVN 572
+ GWRP + YN+WVSL G ++C +M +I+W +++T I F LY+ V + PDVN
Sbjct: 591 YAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVN 650
Query: 573 WGSSTQAQMYKTALSSAHNLARTGEHVKNYWPQLLVLGGRAHARPPLVDLGSLITKAGSL 632
WGSSTQA Y +AL +A L +HVKN+ PQ +VL G RP L+D+ TK L
Sbjct: 651 WGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGL 710
Query: 633 MIIGD--ISKEKLSYKVCSARARADNEWLQERKVRAFCSLVHGFNFEQGARALIQATGVG 690
I + + KL K ++ WL + K++AF + V F G R+L+QA+G+G
Sbjct: 711 CICCEVFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLG 770
Query: 691 KLAPNVLLMGYKSDWTTASAEDLVAYFNVLHTAFENRLAVAIVRVRGGLD 740
++ PN L++GYK +W A ++ Y ++H AF+ + V IVR+ G D
Sbjct: 771 RMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQGFD 820
Score = 171 bits (416), Expect = 1e-41
Identities = 88/199 (44%), Positives = 127/199 (63%), Gaps = 13/199 (6%)
Query: 850 FKRKQESGTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIFXXXXXXXXXXXXXXXXX 909
FK+KQE GT+DVWWL+DD GLT+L+PYI++ R W +CKLRI+
Sbjct: 902 FKKKQEKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIAMAS 961
Query: 910 XXXSKFRIDYSSLTMVQDITEPPQAETKALFDETIKKF----------TSDSAAPEC--R 957
SKFRI ++ + ++ DI P E+ +F+E I+ + T++ E +
Sbjct: 962 LL-SKFRIKFADIHIIGDINIRPNKESWKVFEEMIEPYRLHESCKDLTTAEKLKRETPWK 1020
Query: 958 ISETELTTLSGKTNRQLRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMSRD 1017
I++ EL + K+ RQ+RL ELL +SR + LIV+SLP+ RKGS+S LYMAWLE+++++
Sbjct: 1021 ITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKN 1080
Query: 1018 LPPMLFVRGNHTSVLTFYS 1036
LPP+L VRGNH +VLTFYS
Sbjct: 1081 LPPVLLVRGNHKNVLTFYS 1099
>U44128-1|AAC50355.1| 1030|Homo sapiens thiazide-sensitive Na-Cl
protein.
Length = 1030
Score = 537 bits (1325), Expect = e-152
Identities = 275/647 (42%), Positives = 390/647 (60%), Gaps = 11/647 (1%)
Query: 100 EGVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVK 159
+GV+I C+LNIWGV+L+LR+ W+ +QAGI + +II LS V IT LS+SAI TNG+VK
Sbjct: 140 KGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVK 199
Query: 160 GGGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFCDSMNHLLKSLDLQIIDNSYN 219
GG Y++ISRSLGPE G S+G+IFAFANAV +M+T+GF +++ LL+ I+D N
Sbjct: 200 SGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGAPIVD-PIN 258
Query: 220 DVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAVMGPKSNLEVAEGF 279
D+RIIG +++ V+ I GM+WESKAQ +I+ + +++VG ++ P + + ++GF
Sbjct: 259 DIRIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSED-KASKGF 317
Query: 280 VGLSTSTFVENFNSDFKYSEGMEQNFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKG 339
FV+N D++ +G FF +F+IFFPS TGI AGANISGDLKDPA AIPKG
Sbjct: 318 FSYRADIFVQNLVPDWRGPDG---TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKG 374
Query: 340 TLLALLISMVSYAMMVLFTGAAALRDASGNITDLVISNGTVTNYSAVSQCANST----LF 395
TL+A+ + +SY + G+ +RDASG + D V A S N T
Sbjct: 375 TLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQH 434
Query: 396 PCKYGMHVDFEIMQLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIF 455
C YG+ ++ M ++S + P I AG + ++ Q L D++YP + F
Sbjct: 435 SCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGF 494
Query: 456 FSKPYGRHGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAALVR 515
F K YG++ E RGY IA+LN IAP+ISNF+L SYALINF FHA++
Sbjct: 495 FGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITN 554
Query: 516 PLGWRPTFKYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNWGS 575
GWRP+F+YYN W +L G ++ V IM L++W +L+ I + L L V Y+ P+VNWGS
Sbjct: 555 SPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGS 614
Query: 576 STQAQMYKTALSSAHNLARTGEHVKNYWPQLLVLGGRAHARPPLVDLGSLITKAGSLMII 635
S QA Y ALS + L +H+KNY PQ LVL G + RP LVD T+ SLMI
Sbjct: 615 SVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVGTFTRNLSLMIC 674
Query: 636 GD--ISKEKLSYKVCSARARADNEWLQERKVRAFCSLVHGFNFEQGARALIQATGVGKLA 693
G I K A +WL +RK++AF S V + +G + L+QA G+G++
Sbjct: 675 GHVLIGPHKQRMPELQLIANGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMK 734
Query: 694 PNVLLMGYKSDWTTASAEDLVAYFNVLHTAFENRLAVAIVRVRGGLD 740
PN+L++G+K +W +A + Y +LH AFE V ++R+R GL+
Sbjct: 735 PNILVVGFKKNWQSAHPATVEDYIGILHDAFEFNYGVCVMRMREGLN 781
Score = 145 bits (351), Expect = 8e-34
Identities = 76/201 (37%), Positives = 120/201 (59%), Gaps = 14/201 (6%)
Query: 848 SIFKRKQESGTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIFXXXXXXXXXXXXXXX 907
+IF+ +Q T+D++WL+DD GLT+L+PY++ ++ W CK+R+F
Sbjct: 829 TIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAI 888
Query: 908 XXXXXSKFRIDYSSLTMVQDITEPPQAETKALFDETIKKF----------TSDSAAPEC- 956
SKFR+ + + ++ DI + P+AE F++ I F T + +C
Sbjct: 889 ISLL-SKFRLGFHEVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCP 947
Query: 957 -RISETELTTLSGKTNRQLRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMS 1015
+IS+ E+T K+ RQ+RL E++L SRD+ LIV++LP+ RKG + LYMAWLE +S
Sbjct: 948 WKISDEEITKNRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLS 1007
Query: 1016 RDL-PPMLFVRGNHTSVLTFY 1035
+DL PP++ +RGN +VLTFY
Sbjct: 1008 QDLRPPVILIRGNQENVLTFY 1028
>X91220-1|CAA62613.1| 1021|Homo sapiens NaCl electroneutral
Thiazide-sensitive cotransporter protein.
Length = 1021
Score = 530 bits (1309), Expect = e-150
Identities = 272/647 (42%), Positives = 388/647 (59%), Gaps = 11/647 (1%)
Query: 100 EGVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVK 159
+GV+I C+LNIWGV+L+LR+ W+ +QAGI + +II LS V IT LS+SAI TNG+VK
Sbjct: 140 KGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVK 199
Query: 160 GGGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFCDSMNHLLKSLDLQIIDNSYN 219
GG Y++ISRSLGPE G S+G+IFAFANAV +M+T+GF +++ LL+ I+D N
Sbjct: 200 SGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGAPIVD-PIN 258
Query: 220 DVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAVMGPKSNLEVAEGF 279
D+RIIG +++ V+ I GM+WESKAQ +I+ + +++VG ++ P + + ++GF
Sbjct: 259 DIRIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSED-KASKGF 317
Query: 280 VGLSTSTFVENFNSDFKYSEGMEQNFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKG 339
FV+N D++ +G FF +F+IFFPS TGI AGANISGDLKDPA AIPKG
Sbjct: 318 FSYRADIFVQNLVPDWRGPDG---TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKG 374
Query: 340 TLLALLISMVSYAMMVLFTGAAALRDASGNITDLVISNGTVTNYSAVSQCANST----LF 395
TL+A+ + +SY + G+ +RDASG + D V A S N T
Sbjct: 375 TLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQH 434
Query: 396 PCKYGMHVDFEIMQLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIF 455
C YG+ ++ M ++S + P I + ++ Q L D++YP + F
Sbjct: 435 SCHYGLINYYQTMSMVSGFAPLITVVIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGF 494
Query: 456 FSKPYGRHGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAALVR 515
F K YG++ E RGY IA+LN IAP+ISNF+L SYALINF FHA++
Sbjct: 495 FGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITN 554
Query: 516 PLGWRPTFKYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNWGS 575
GWRP+F+YYN W +L G ++ V IM L++W +L+ I + L L V Y+ P+VNWGS
Sbjct: 555 SPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGS 614
Query: 576 STQAQMYKTALSSAHNLARTGEHVKNYWPQLLVLGGRAHARPPLVDLGSLITKAGSLMII 635
S QA Y ALS + L +H+KNY PQ LVL G + RP LVD T+ SLMI
Sbjct: 615 SVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVGTFTRNLSLMIC 674
Query: 636 GD--ISKEKLSYKVCSARARADNEWLQERKVRAFCSLVHGFNFEQGARALIQATGVGKLA 693
G I K A +WL +RK++AF S V + +G + L+QA G+G++
Sbjct: 675 GHVLIGPHKQRMPELQLIANGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMK 734
Query: 694 PNVLLMGYKSDWTTASAEDLVAYFNVLHTAFENRLAVAIVRVRGGLD 740
PN+L++G+K +W +A + Y +LH AF+ V ++R+R GL+
Sbjct: 735 PNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMREGLN 781
Score = 145 bits (351), Expect = 8e-34
Identities = 76/201 (37%), Positives = 120/201 (59%), Gaps = 14/201 (6%)
Query: 848 SIFKRKQESGTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIFXXXXXXXXXXXXXXX 907
+IF+ +Q T+D++WL+DD GLT+L+PY++ ++ W CK+R+F
Sbjct: 820 TIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAI 879
Query: 908 XXXXXSKFRIDYSSLTMVQDITEPPQAETKALFDETIKKF----------TSDSAAPEC- 956
SKFR+ + + ++ DI + P+AE F++ I F T + +C
Sbjct: 880 ISLL-SKFRLGFHEVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCP 938
Query: 957 -RISETELTTLSGKTNRQLRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMS 1015
+IS+ E+T K+ RQ+RL E++L SRD+ LIV++LP+ RKG + LYMAWLE +S
Sbjct: 939 WKISDEEITKNRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLS 998
Query: 1016 RDL-PPMLFVRGNHTSVLTFY 1035
+DL PP++ +RGN +VLTFY
Sbjct: 999 QDLRPPVILIRGNQENVLTFY 1019
>BC040138-1|AAH40138.1| 430|Homo sapiens SLC12A1 protein protein.
Length = 430
Score = 260 bits (637), Expect = 2e-68
Identities = 132/244 (54%), Positives = 173/244 (70%), Gaps = 10/244 (4%)
Query: 100 EGVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVK 159
+GVL+ C+LNIWGVMLF+R+SW+V +AGIG ++II LS +V IT LS SAI TNG V+
Sbjct: 181 KGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVR 240
Query: 160 GGGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFCDSMNHLLKSLDLQIIDNSYN 219
GGG YY+ISRSLGPEFG S+G+IFAFANAVA +M +GF +++ LLK D ++D + N
Sbjct: 241 GGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVDPT-N 299
Query: 220 DVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAVMGPKSNLEVAEGF 279
D+RIIG+I + ++ I GM+WE+KAQ L+ I++ AI +F +G V+ P +N + + GF
Sbjct: 300 DIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVI-PSNNEKKSRGF 358
Query: 280 VGLSTSTFVENFNSDFKYSEGMEQNFFSVFAIFFPSVTGIQAGANISGDL----KDPASA 335
S F ENF F EG FFSVFAIFFP+ TGI AGANISGDL K AS
Sbjct: 359 FNYQASIFAENFGPRFTKGEG----FFSVFAIFFPAATGILAGANISGDLEALRKQGASP 414
Query: 336 IPKG 339
+P+G
Sbjct: 415 LPQG 418
>BC126160-1|AAI26161.1| 714|Homo sapiens solute carrier family 12
(potassium/chloride transporters), member 8 protein.
Length = 714
Score = 165 bits (401), Expect = 7e-40
Identities = 92/269 (34%), Positives = 150/269 (55%), Gaps = 15/269 (5%)
Query: 98 TEEGVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGE 157
T +GV C++NI+GV+LFLR W+V G+ + +++ +V ++T LS +
Sbjct: 41 TWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSS 100
Query: 158 VKGGGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFCDSMNHLLKSLDLQIIDNS 217
+ GG+Y +IS LG + G ++G+++ F VA +M GF +S++ LL + N
Sbjct: 101 IGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLLG------LGNI 154
Query: 218 YNDVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAVMGPKSNLEVAE 277
+ VR I L + I G+ W + Q L+ ++ + +DFVVG+ ++L+
Sbjct: 155 W-AVRGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDFVVGSF----THLDPEH 209
Query: 278 GFVGLSTSTFVENFNSDFKYSEGMEQNFFSVFAIFFPSVTGIQAGANISGDLKDPASAIP 337
GF+G S N D YS G ++FF+VF +FFP+ TG+ AG N+ GDL++PA++IP
Sbjct: 210 GFIGYSPELLQNNTLPD--YSPG--ESFFTVFGVFFPAATGVMAGFNMGGDLREPAASIP 265
Query: 338 KGTLLALLISMVSYAMMVLFTGAAALRDA 366
G+L A+ IS Y + V GA R+A
Sbjct: 266 LGSLAAVGISWFLYIVFVFLLGAICTREA 294
Score = 41.1 bits (92), Expect = 0.020
Identities = 19/69 (27%), Positives = 37/69 (53%), Gaps = 4/69 (5%)
Query: 519 WRPTFKYY----NVWVSLAGFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNWG 574
WR + +Y N WVSL G + + IM +I W+ +LV + + +Y + +P ++ G
Sbjct: 582 WRRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLG 641
Query: 575 SSTQAQMYK 583
S++ ++
Sbjct: 642 SASNFSFFR 650
Score = 36.3 bits (80), Expect = 0.57
Identities = 17/113 (15%), Positives = 44/113 (38%)
Query: 401 MHVDFEIMQLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFSKPY 460
+ DF I + +S G G + PR++Q + +++ P L +
Sbjct: 295 LRYDFLIAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGK 354
Query: 461 GRHGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAAL 513
G + + ++N +AP+++ ++ +Y +++ F ++
Sbjct: 355 GPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSM 407
>BC126158-1|AAI26159.1| 714|Homo sapiens solute carrier family 12
(potassium/chloride transporters), member 8 protein.
Length = 714
Score = 165 bits (401), Expect = 7e-40
Identities = 92/269 (34%), Positives = 150/269 (55%), Gaps = 15/269 (5%)
Query: 98 TEEGVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGE 157
T +GV C++NI+GV+LFLR W+V G+ + +++ +V ++T LS +
Sbjct: 41 TWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSS 100
Query: 158 VKGGGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFCDSMNHLLKSLDLQIIDNS 217
+ GG+Y +IS LG + G ++G+++ F VA +M GF +S++ LL + N
Sbjct: 101 IGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLLG------LGNI 154
Query: 218 YNDVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAVMGPKSNLEVAE 277
+ VR I L + I G+ W + Q L+ ++ + +DFVVG+ ++L+
Sbjct: 155 W-AVRGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDFVVGSF----THLDPEH 209
Query: 278 GFVGLSTSTFVENFNSDFKYSEGMEQNFFSVFAIFFPSVTGIQAGANISGDLKDPASAIP 337
GF+G S N D YS G ++FF+VF +FFP+ TG+ AG N+ GDL++PA++IP
Sbjct: 210 GFIGYSPELLQNNTLPD--YSPG--ESFFTVFGVFFPAATGVMAGFNMGGDLREPAASIP 265
Query: 338 KGTLLALLISMVSYAMMVLFTGAAALRDA 366
G+L A+ IS Y + V GA R+A
Sbjct: 266 LGSLAAVGISWFLYIVFVFLLGAICTREA 294
Score = 41.1 bits (92), Expect = 0.020
Identities = 19/69 (27%), Positives = 37/69 (53%), Gaps = 4/69 (5%)
Query: 519 WRPTFKYY----NVWVSLAGFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNWG 574
WR + +Y N WVSL G + + IM +I W+ +LV + + +Y + +P ++ G
Sbjct: 582 WRRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLG 641
Query: 575 SSTQAQMYK 583
S++ ++
Sbjct: 642 SASNFSFFR 650
Score = 36.3 bits (80), Expect = 0.57
Identities = 17/113 (15%), Positives = 44/113 (38%)
Query: 401 MHVDFEIMQLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFSKPY 460
+ DF I + +S G G + PR++Q + +++ P L +
Sbjct: 295 LRYDFLIAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGK 354
Query: 461 GRHGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAAL 513
G + + ++N +AP+++ ++ +Y +++ F ++
Sbjct: 355 GPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSM 407
>AF390442-1|AAM73657.1| 731|Homo sapiens solute carrier family 12
member 8 protein.
Length = 731
Score = 165 bits (401), Expect = 7e-40
Identities = 92/269 (34%), Positives = 150/269 (55%), Gaps = 15/269 (5%)
Query: 98 TEEGVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGE 157
T +GV C++NI+GV+LFLR W+V G+ + +++ +V ++T LS +
Sbjct: 58 TWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSS 117
Query: 158 VKGGGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFCDSMNHLLKSLDLQIIDNS 217
+ GG+Y +IS LG + G ++G+++ F VA +M GF +S++ LL + N
Sbjct: 118 IGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLLG------LGNI 171
Query: 218 YNDVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAVMGPKSNLEVAE 277
+ VR I L + I G+ W + Q L+ ++ + +DFVVG+ ++L+
Sbjct: 172 W-AVRGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDFVVGSF----THLDPEH 226
Query: 278 GFVGLSTSTFVENFNSDFKYSEGMEQNFFSVFAIFFPSVTGIQAGANISGDLKDPASAIP 337
GF+G S N D YS G ++FF+VF +FFP+ TG+ AG N+ GDL++PA++IP
Sbjct: 227 GFIGYSPELLQNNTLPD--YSPG--ESFFTVFGVFFPAATGVMAGFNMGGDLREPAASIP 282
Query: 338 KGTLLALLISMVSYAMMVLFTGAAALRDA 366
G+L A+ IS Y + V GA R+A
Sbjct: 283 LGSLAAVGISWFLYIVFVFLLGAICTREA 311
Score = 41.1 bits (92), Expect = 0.020
Identities = 19/69 (27%), Positives = 37/69 (53%), Gaps = 4/69 (5%)
Query: 519 WRPTFKYY----NVWVSLAGFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNWG 574
WR + +Y N WVSL G + + IM +I W+ +LV + + +Y + +P ++ G
Sbjct: 599 WRRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLG 658
Query: 575 SSTQAQMYK 583
S++ ++
Sbjct: 659 SASNFSFFR 667
Score = 35.5 bits (78), Expect = 0.99
Identities = 17/113 (15%), Positives = 44/113 (38%)
Query: 401 MHVDFEIMQLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFSKPY 460
+ DF I + +S G G + PR++Q + +++ P L +
Sbjct: 312 LRYDFLIAEKVSLMGFLFLLGLYIPSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGK 371
Query: 461 GRHGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAAL 513
G + + ++N +AP+++ ++ +Y +++ F ++
Sbjct: 372 GPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSM 424
>AF345197-1|AAO49174.1| 714|Homo sapiens cation-chloride
cotransporter 9 protein.
Length = 714
Score = 165 bits (401), Expect = 7e-40
Identities = 92/269 (34%), Positives = 150/269 (55%), Gaps = 15/269 (5%)
Query: 98 TEEGVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGE 157
T +GV C++NI+GV+LFLR W+V G+ + +++ +V ++T LS +
Sbjct: 41 TWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSS 100
Query: 158 VKGGGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFCDSMNHLLKSLDLQIIDNS 217
+ GG+Y +IS LG + G ++G+++ F VA +M GF +S++ LL + N
Sbjct: 101 IGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLLG------LGNI 154
Query: 218 YNDVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAVMGPKSNLEVAE 277
+ VR I L + I G+ W + Q L+ ++ + +DFVVG+ ++L+
Sbjct: 155 W-AVRGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDFVVGSF----THLDPEH 209
Query: 278 GFVGLSTSTFVENFNSDFKYSEGMEQNFFSVFAIFFPSVTGIQAGANISGDLKDPASAIP 337
GF+G S N D YS G ++FF+VF +FFP+ TG+ AG N+ GDL++PA++IP
Sbjct: 210 GFIGYSPELLQNNTLPD--YSPG--ESFFTVFGVFFPAATGVMAGFNMGGDLREPAASIP 265
Query: 338 KGTLLALLISMVSYAMMVLFTGAAALRDA 366
G+L A+ IS Y + V GA R+A
Sbjct: 266 LGSLAAVGISWFLYIVFVFLLGAICTREA 294
Score = 41.1 bits (92), Expect = 0.020
Identities = 19/69 (27%), Positives = 37/69 (53%), Gaps = 4/69 (5%)
Query: 519 WRPTFKYY----NVWVSLAGFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNWG 574
WR + +Y N WVSL G + + IM +I W+ +LV + + +Y + +P ++ G
Sbjct: 582 WRRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLG 641
Query: 575 SSTQAQMYK 583
S++ ++
Sbjct: 642 SASNFSFFR 650
Score = 36.3 bits (80), Expect = 0.57
Identities = 17/113 (15%), Positives = 44/113 (38%)
Query: 401 MHVDFEIMQLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFSKPY 460
+ DF I + +S G G + PR++Q + +++ P L +
Sbjct: 295 LRYDFLIAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGK 354
Query: 461 GRHGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAAL 513
G + + ++N +AP+++ ++ +Y +++ F ++
Sbjct: 355 GPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSM 407
>AF312032-7|AAK21009.1| 627|Homo sapiens cation-chloride
cotransporter-interacting protein 1 isoform b protein.
Length = 627
Score = 162 bits (393), Expect = 7e-39
Identities = 91/280 (32%), Positives = 162/280 (57%), Gaps = 21/280 (7%)
Query: 96 LITEEGVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTN 155
L T GV++P +L+++ +++FLRI +VV AG+ +L ++ ++ + +T LS+ AI TN
Sbjct: 37 LSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVCAIATN 96
Query: 156 GEVKGGGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFCDSMNHLLKS-----LD 210
G V+GGG Y++ISR+LGPE G S+G++F AN +++ +G +S+ + +
Sbjct: 97 GAVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVLDVFGADATGPSG 156
Query: 211 LQIIDNSYNDVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAV-MGP 269
L+++ Y + G++ L ++ +C +G ++A ++ G++ ++ V +GP
Sbjct: 157 LRVLPQGYGWNLLYGSLLLGLVGGVCTLGAGLYARASFLTFLLVSGSLASVLISFVAVGP 216
Query: 270 K------------SNLEVAEG-FVGLSTSTFVENFNSDF--KYSEGMEQNFFSVFAIFFP 314
+ S+L G F G ++ST +N + + Y+ G NF SVFA+ F
Sbjct: 217 RDIRLTPRPGPNGSSLPPRFGHFTGFNSSTLKDNLGAGYAEDYTTGAVMNFASVFAVLFN 276
Query: 315 SVTGIQAGANISGDLKDPASAIPKGTLLALLISMVSYAMM 354
TGI AGAN+SG+LKDP+ AIP GT++A+ + Y ++
Sbjct: 277 GCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLL 316
Score = 93.9 bits (223), Expect = 3e-18
Identities = 67/289 (23%), Positives = 120/289 (41%), Gaps = 4/289 (1%)
Query: 404 DFEIMQLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFSKPYGRH 463
D+ + +S W P + G + R++ AL D ++ ++ +K R
Sbjct: 332 DYGFFRAISLWPPLVLIGIYATALSASMSSLIGASRILHALARDDLFGVILAPAKVVSRG 391
Query: 464 GEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAALVRPLGWRPTF 523
G + KLN +A +++ FYL +YA ++ +RPTF
Sbjct: 392 GNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTF 451
Query: 524 KYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNWGSSTQAQMYK 583
++ L G C+ +M LIS + ++ + L ++ R +WG +QA ++
Sbjct: 452 SLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLAALLTARGGPSSWGYVSQALLFH 511
Query: 584 TALSSAHNLARTGEHVKNYWPQLLVLGGRAHARPPLVDLGSLITKAGSLMIIGDISKEKL 643
L +HVK + PQLL+L G PL+ L + + K G L ++G ++ L
Sbjct: 512 QVRKYLLRLDVRKDHVKFWRPQLLLLVGNPRGALPLLRLANQL-KKGGLYVLGHVTLGDL 570
Query: 644 SYKVCSARARADNEWL---QERKVRAFCSLVHGFNFEQGARALIQATGV 689
WL +V+AF L + QGA+ L++ +G+
Sbjct: 571 DSLPSDPVQPQYGAWLSLVDRAQVKAFVDLTLSPSVRQGAQHLLRISGL 619
>AF312032-6|AAK21008.1| 914|Homo sapiens cation-chloride
cotransporter-interacting protein 1 protein.
Length = 914
Score = 162 bits (393), Expect = 7e-39
Identities = 91/280 (32%), Positives = 162/280 (57%), Gaps = 21/280 (7%)
Query: 96 LITEEGVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTN 155
L T GV++P +L+++ +++FLRI +VV AG+ +L ++ ++ + +T LS+ AI TN
Sbjct: 37 LSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVCAIATN 96
Query: 156 GEVKGGGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFCDSMNHLLKS-----LD 210
G V+GGG Y++ISR+LGPE G S+G++F AN +++ +G +S+ + +
Sbjct: 97 GAVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVLDVFGADATGPSG 156
Query: 211 LQIIDNSYNDVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAV-MGP 269
L+++ Y + G++ L ++ +C +G ++A ++ G++ ++ V +GP
Sbjct: 157 LRVLPQGYGWNLLYGSLLLGLVGGVCTLGAGLYARASFLTFLLVSGSLASVLISFVAVGP 216
Query: 270 K------------SNLEVAEG-FVGLSTSTFVENFNSDF--KYSEGMEQNFFSVFAIFFP 314
+ S+L G F G ++ST +N + + Y+ G NF SVFA+ F
Sbjct: 217 RDIRLTPRPGPNGSSLPPRFGHFTGFNSSTLKDNLGAGYAEDYTTGAVMNFASVFAVLFN 276
Query: 315 SVTGIQAGANISGDLKDPASAIPKGTLLALLISMVSYAMM 354
TGI AGAN+SG+LKDP+ AIP GT++A+ + Y ++
Sbjct: 277 GCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLL 316
Score = 109 bits (261), Expect = 7e-23
Identities = 73/304 (24%), Positives = 130/304 (42%), Gaps = 4/304 (1%)
Query: 404 DFEIMQLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFSKPYGRH 463
D+ + +S W P + G + R++ AL D ++ ++ +K R
Sbjct: 332 DYGFFRAISLWPPLVLIGIYATALSASMSSLIGASRILHALARDDLFGVILAPAKVVSRG 391
Query: 464 GEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAALVRPLGWRPTF 523
G + KLN +A +++ FYL +YA ++ +RPTF
Sbjct: 392 GNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTF 451
Query: 524 KYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNWGSSTQAQMYK 583
++ L G C+ +M LIS + ++ + L ++ R +WG +QA ++
Sbjct: 452 SLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLAALLTARGGPSSWGYVSQALLFH 511
Query: 584 TALSSAHNLARTGEHVKNYWPQLLVLGGRAHARPPLVDLGSLITKAGSLMIIGDISKEKL 643
L +HVK + PQLL+L G PL+ L + + K G L ++G ++ L
Sbjct: 512 QVRKYLLRLDVRKDHVKFWRPQLLLLVGNPRGALPLLRLANQL-KKGGLYVLGHVTLGDL 570
Query: 644 SYKVCSARARADNEWL---QERKVRAFCSLVHGFNFEQGARALIQATGVGKLAPNVLLMG 700
WL +V+AF L + QGA+ L++ +G+G + PN L++G
Sbjct: 571 DSLPSDPVQPQYGAWLSLVDRAQVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLG 630
Query: 701 YKSD 704
+ D
Sbjct: 631 FYDD 634
Score = 32.7 bits (71), Expect = 7.0
Identities = 16/38 (42%), Positives = 20/38 (52%)
Query: 989 LIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRG 1026
L + LP P P Y+A LE ++RDL P L V G
Sbjct: 868 LTFLYLPRPPADPARYPRYLALLETLTRDLGPTLLVHG 905
>BC051744-1|AAH51744.1| 943|Homo sapiens SLC12A6 protein protein.
Length = 943
Score = 161 bits (392), Expect = 9e-39
Identities = 119/427 (27%), Positives = 183/427 (42%), Gaps = 38/427 (8%)
Query: 304 NFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKGTLLALLISMVSYAMMVLFTGAAAL 363
+F + IFFPSVTGI AG+N SGDLKD +IP GT+LA+L
Sbjct: 425 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILT----------------- 467
Query: 364 RDASGNITDLVISNGTVTNYSAVSQCANSTLFPCKYGMHVDFEIMQLMSAW-GPFIYA-G 421
T V+ V + A C + K+G V ++ +W P++ G
Sbjct: 468 -------TSFVLDLSNVVLFGA---CIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIG 517
Query: 422 CWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFSKPYGRHGEAYRGYXXXXXXXXXXX 481
+ PRL+QA+ D I P L F +GE
Sbjct: 518 SFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTAAIAELGI 576
Query: 482 XIAKLNAIAPLISNFYLASYALINFCTFHAALVRPLGWRPTFKYYNVWVSLAGFLMCVGI 541
IA L+ +AP++S F+L Y +N L+R WRP F+YY+ +S G +C+ +
Sbjct: 577 LIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLAL 636
Query: 542 MLLISWIMSLVTIAIFFTLYLIVHYRNPDVNWGSSTQAQMYKTALSSAHNLARTGEHVKN 601
M + SW ++V + I +Y + Y+ + WG + A + L H KN
Sbjct: 637 MFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKN 696
Query: 602 YWPQLLV---LGGRAHAR-PPLVDLGSLITKAGSLMIIGDISKEKL--SYKVCSARARAD 655
+ PQLLV L H + P L+ S + L I+G + +Y A +
Sbjct: 697 WRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTI 756
Query: 656 NEWLQERKVRAFCSLVHGFNFEQGARALIQATGVGKLAPNVLLMGYKSDWTTASAEDLVA 715
++ KV+ FC LV +G LIQ+ G+G + N ++MG+ + W +ED A
Sbjct: 757 KHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGW--RQSEDARA 814
Query: 716 YFNVLHT 722
+ + T
Sbjct: 815 WKTFIGT 821
Score = 117 bits (281), Expect = 3e-25
Identities = 60/174 (34%), Positives = 104/174 (59%), Gaps = 8/174 (4%)
Query: 101 GVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVKG 160
GV +PCL NI+GV+LFLR++WVV AG+ + I+ + ++T +SMSAI TNG V
Sbjct: 131 GVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPA 190
Query: 161 GGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFCD-SMNHLLKSLDLQIIDNS-- 217
GG Y++ISR+LGPEFG +VG+ F AA+M +G + + +++ + D++
Sbjct: 191 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 250
Query: 218 -----YNDVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAV 266
N++R+ G L +M ++ +G+ + +K + +A ++ +I+ GA+
Sbjct: 251 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAI 304
Score = 50.0 bits (114), Expect = 4e-05
Identities = 16/36 (44%), Positives = 24/36 (66%)
Query: 857 GTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIF 892
G +DVWW+ D G+ +LLP+++ Q W C +RIF
Sbjct: 851 GNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIF 886
>AB033284-1|BAB40456.1| 914|Homo sapiens cation chloride
cotransporter 6 protein.
Length = 914
Score = 161 bits (391), Expect = 1e-38
Identities = 90/280 (32%), Positives = 160/280 (57%), Gaps = 21/280 (7%)
Query: 96 LITEEGVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTN 155
L T GV++P +L+++ +++FLRI +VV AG+ +L ++ ++ + +T LS+ AI TN
Sbjct: 37 LSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVCAIATN 96
Query: 156 GEVKGGGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFCDSMNHLLKS-----LD 210
G V+GGG Y++ISR+LGPE G S+G++F AN +++ +G +S+ + +
Sbjct: 97 GAVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVLDVFGADATGPSG 156
Query: 211 LQIIDNSYNDVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAV-MGP 269
L+++ Y + G++ L ++ +C +G ++A ++ G++ ++ V +GP
Sbjct: 157 LRVLPQGYGWNLLYGSLLLGLVGGVCTLGAGLYARASFLTFLLVSGSLASVLISFVAVGP 216
Query: 270 KS-NLEVAEG------------FVGLSTSTFVENFNSDFK--YSEGMEQNFFSVFAIFFP 314
+ L G F G ++ST +N + + Y+ G NF SVFA+ F
Sbjct: 217 RDIRLSPRPGPNGSALPPRFGHFTGFNSSTLKDNLGAGYAEDYTTGAVMNFASVFAVLFN 276
Query: 315 SVTGIQAGANISGDLKDPASAIPKGTLLALLISMVSYAMM 354
TGI AGAN+SG+LKDP+ AIP GT++A+ + Y ++
Sbjct: 277 GCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLL 316
Score = 109 bits (261), Expect = 7e-23
Identities = 73/304 (24%), Positives = 130/304 (42%), Gaps = 4/304 (1%)
Query: 404 DFEIMQLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFSKPYGRH 463
D+ + +S W P + G + R++ AL D ++ ++ +K R
Sbjct: 332 DYGFFRAISLWPPLVLIGIYATALSASMSSLIGASRILHALARDDLFGVILAPAKVVSRG 391
Query: 464 GEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAALVRPLGWRPTF 523
G + KLN +A +++ FYL +YA ++ +RPTF
Sbjct: 392 GNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTF 451
Query: 524 KYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNWGSSTQAQMYK 583
++ L G C+ +M LIS + ++ + L ++ R +WG +QA ++
Sbjct: 452 SLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLAALLTARGGPSSWGYVSQALLFH 511
Query: 584 TALSSAHNLARTGEHVKNYWPQLLVLGGRAHARPPLVDLGSLITKAGSLMIIGDISKEKL 643
L +HVK + PQLL+L G PL+ L + + K G L ++G ++ L
Sbjct: 512 QVRKYLLRLDVRKDHVKFWRPQLLLLVGNPRGALPLLRLANQL-KKGGLYVLGHVTLGDL 570
Query: 644 SYKVCSARARADNEWL---QERKVRAFCSLVHGFNFEQGARALIQATGVGKLAPNVLLMG 700
WL +V+AF L + QGA+ L++ +G+G + PN L++G
Sbjct: 571 DSLPSDPVQPQYGAWLSLVDRAQVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLG 630
Query: 701 YKSD 704
+ D
Sbjct: 631 FYDD 634
Score = 32.7 bits (71), Expect = 7.0
Identities = 16/38 (42%), Positives = 20/38 (52%)
Query: 989 LIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRG 1026
L + LP P P Y+A LE ++RDL P L V G
Sbjct: 868 LTFLYLPRPPADPARYPRYLALLETLTRDLGPTLLVHG 905
>AF284422-1|AAF88060.1| 914|Homo sapiens cation-chloride
cotransporter-interacting protein protein.
Length = 914
Score = 161 bits (390), Expect = 2e-38
Identities = 90/280 (32%), Positives = 162/280 (57%), Gaps = 21/280 (7%)
Query: 96 LITEEGVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTN 155
L T GV++P +L+++ +++FLRI +VV AG+ +L ++ ++ + +T LS+ AI TN
Sbjct: 37 LSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVCAIATN 96
Query: 156 GEVKGGGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFCDSMNHLLKS-----LD 210
G V+GGG Y++ISR+LGPE G S+G++F AN +++ +G +S+ + +
Sbjct: 97 GAVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVLDVFGADATGPSG 156
Query: 211 LQIIDNSYNDVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAV-MGP 269
L+++ Y + G++ L ++ +C +G ++A ++ G++ ++ V +GP
Sbjct: 157 LRVLPQGYGWNLLYGSLLLGLVGGVCTLGAGLYARASFLTFLLVSGSLASVLISFVAVGP 216
Query: 270 K------------SNLEVAEG-FVGLSTSTFVENFNSDF--KYSEGMEQNFFSVFAIFFP 314
+ S+L G F G ++ST +N + + Y+ G NF +VFA+ F
Sbjct: 217 RDIRLTPRPGPNGSSLPPRFGHFTGFNSSTLKDNLGAGYAEDYTTGAVMNFANVFAVLFN 276
Query: 315 SVTGIQAGANISGDLKDPASAIPKGTLLALLISMVSYAMM 354
TGI AGAN+SG+LKDP+ AIP GT++A+ + Y ++
Sbjct: 277 GCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLL 316
Score = 109 bits (263), Expect = 4e-23
Identities = 73/304 (24%), Positives = 130/304 (42%), Gaps = 4/304 (1%)
Query: 404 DFEIMQLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFSKPYGRH 463
D+ + +S W P + G + R++ AL D ++ ++ +K R
Sbjct: 332 DYGFFRAISLWPPLVLIGIYATALSASMSSLIGASRILHALARDDLFGVILAPAKVVSRG 391
Query: 464 GEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAALVRPLGWRPTF 523
G + KLN +A +++ FYL +YA ++ +RPTF
Sbjct: 392 GNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTF 451
Query: 524 KYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNWGSSTQAQMYK 583
++ L G C+ +M LIS + ++ + L ++ R +WG +QA ++
Sbjct: 452 SLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLAALLTARGGPSSWGYVSQALLFH 511
Query: 584 TALSSAHNLARTGEHVKNYWPQLLVLGGRAHARPPLVDLGSLITKAGSLMIIGDISKEKL 643
L +HVK + PQLL+L G PL+ L + + K G L ++G ++ L
Sbjct: 512 QVRKYLLRLDVRKDHVKFWRPQLLLLVGNPRGALPLLRLANQL-KKGGLYVLGHVTLGDL 570
Query: 644 SYKVCSARARADNEWL---QERKVRAFCSLVHGFNFEQGARALIQATGVGKLAPNVLLMG 700
WL +V+AF L + QGA+ L++ +G+G + PN L++G
Sbjct: 571 DSLPSDPVQPQYGAWLSLVDRAQVKAFVDLTFSPSVRQGAQHLLRISGLGGMKPNTLVLG 630
Query: 701 YKSD 704
+ D
Sbjct: 631 FYDD 634
Score = 32.7 bits (71), Expect = 7.0
Identities = 16/38 (42%), Positives = 20/38 (52%)
Query: 989 LIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRG 1026
L + LP P P Y+A LE ++RDL P L V G
Sbjct: 868 LTFLYLPRPPADPARYPRYLALLETLTRDLGPTLLVHG 905
>AF439152-1|AAL32454.1| 311|Homo sapiens sodium-potassium-chloride
cotransporter protein.
Length = 311
Score = 148 bits (358), Expect = 1e-34
Identities = 74/187 (39%), Positives = 109/187 (58%), Gaps = 2/187 (1%)
Query: 556 IFFTLYLIVHYRNPDVNWGSSTQAQMYKTALSSAHNLARTGEHVKNYWPQLLVLGGRAHA 615
I LY+ V Y+ PDVNWGSSTQA Y AL + L+ +HVKN+ PQ LV+ G ++
Sbjct: 2 IVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGVEDHVKNFRPQCLVMTGAPNS 61
Query: 616 RPPLVDLGSLITKAGSLMIIGDI--SKEKLSYKVCSARARADNEWLQERKVRAFCSLVHG 673
RP L+ L TK LMI G + + + K S WL + K++AF + VH
Sbjct: 62 RPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSIDQAKYQRWLIKNKMKAFYAPVHA 121
Query: 674 FNFEQGARALIQATGVGKLAPNVLLMGYKSDWTTASAEDLVAYFNVLHTAFENRLAVAIV 733
+ +GA+ L+QA G+G++ PN L++G+K DW A D+ Y N+ H AF+ + V ++
Sbjct: 122 DDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQYGVVVI 181
Query: 734 RVRGGLD 740
R++ GLD
Sbjct: 182 RLKEGLD 188
Score = 66.5 bits (155), Expect = 5e-10
Identities = 22/43 (51%), Positives = 35/43 (81%)
Query: 850 FKRKQESGTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIF 892
F++KQ T+DVWWL+DD GLT+L+PY+++ + W +CK+R+F
Sbjct: 260 FQKKQGKNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVF 302
>AK129998-1|BAC85271.1| 342|Homo sapiens protein ( Homo sapiens
cDNA FLJ26488 fis, clone KDN05770, highly similar to
Bumetanide-sensitive sodium-(potassium)-chloride
cotransporter 2. ).
Length = 342
Score = 144 bits (349), Expect = 1e-33
Identities = 66/155 (42%), Positives = 91/155 (58%)
Query: 410 LMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFSKPYGRHGEAYRG 469
++S +GP I AG + P++ QAL D Y L FF+K YG++ E RG
Sbjct: 181 MVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNFYKALQFFAKGYGKNNEPLRG 240
Query: 470 YXXXXXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAALVRPLGWRPTFKYYNVW 529
Y IA+LN IAP+ISNF+LASYALINF FHA+ + GWRP + YN+W
Sbjct: 241 YILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMW 300
Query: 530 VSLAGFLMCVGIMLLISWIMSLVTIAIFFTLYLIV 564
VSL G ++C +M +I+W +++T I F LY+ V
Sbjct: 301 VSLFGAVLCCAVMFVINWWAAVITYVIEFFLYVYV 335
Score = 99.5 bits (237), Expect = 5e-20
Identities = 52/137 (37%), Positives = 77/137 (56%), Gaps = 2/137 (1%)
Query: 575 SSTQAQMYKTALSSAHNLARTGEHVKNYWPQLLVLGGRAHARPPLVDLGSLITKAGSLMI 634
SSTQA Y +AL +A L +HVKN+ PQ +VL G RP L+D+ TK L I
Sbjct: 47 SSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCI 106
Query: 635 IGDI--SKEKLSYKVCSARARADNEWLQERKVRAFCSLVHGFNFEQGARALIQATGVGKL 692
++ KL K ++ WL + K++AF + V F G R+L+QA+G+G++
Sbjct: 107 CCEVFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRM 166
Query: 693 APNVLLMGYKSDWTTAS 709
PN L++GYK +W+ S
Sbjct: 167 KPNTLVIGYKKNWSMVS 183
>U55054-1|AAC50563.1| 1085|Homo sapiens K-Cl cotransporter protein.
Length = 1085
Score = 139 bits (336), Expect = 5e-32
Identities = 99/358 (27%), Positives = 156/358 (43%), Gaps = 17/358 (4%)
Query: 363 LRDASGNI---TDLVISNGTVTNYSAV---SQCANSTLFPCKYGMHVDFEIMQLMSAW-G 415
LRDA +I T L I ++ +S+V C + KYG V ++ AW
Sbjct: 444 LRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPS 503
Query: 416 PFIYA-GCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFSKPYGR-HGEAYRGYXXX 473
P++ G + PRL+QA+ D I P L F +G+ +GE
Sbjct: 504 PWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFG--HGKVNGEPTWALLLT 561
Query: 474 XXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAALVRPLGWRPTFKYYNVWVSLA 533
IA L+ +AP++S F+L Y +N L+R WRP FKYY+ +S
Sbjct: 562 ALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFL 621
Query: 534 GFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNWGSSTQAQMYKTALSSAHNLA 593
G +C+ +M + SW +LV + I +Y + Y+ + WG + A + L
Sbjct: 622 GMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLE 681
Query: 594 RTGEHVKNYWPQLLV---LGGRAHAR-PPLVDLGSLITKAGSLMIIGDISKEKL--SYKV 647
H KN+ PQLLV L H + P L+ S + L I+G + + SY
Sbjct: 682 EGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGE 741
Query: 648 CSARARADNEWLQERKVRAFCSLVHGFNFEQGARALIQATGVGKLAPNVLLMGYKSDW 705
A + ++ KV+ FC +V +G LIQ+ G+G + N +++G+ W
Sbjct: 742 AQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGW 799
Score = 120 bits (290), Expect = 2e-26
Identities = 67/195 (34%), Positives = 112/195 (57%), Gaps = 16/195 (8%)
Query: 80 KRALKRPSLGELHGDHLITEEGVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSA 139
+RA + PS+G L G V +PCL NI+GV+LFLR++W+V AG+ +L+I+ +
Sbjct: 110 RRAAEAPSMGTLMG--------VYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICC 161
Query: 140 VVCVITTLSMSAICTNGEVKGGGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFC 199
++T +SMSAI TNG V GG Y++ISRSLGPEFG +VG+ F AA+M +G
Sbjct: 162 CCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAI 221
Query: 200 D-SMNHLLKSLDL-------QIIDNSYNDVRIIGAIALFVMCVICAVGMDWESKAQNFLI 251
+ + ++ + + + N++R+ G I L M ++ VG+ + +K + +
Sbjct: 222 EILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFL 281
Query: 252 AIIVGAIVDFVVGAV 266
A ++ +I+ G +
Sbjct: 282 ACVIISILSIYAGGI 296
Score = 60.5 bits (140), Expect = 3e-08
Identities = 33/70 (47%), Positives = 46/70 (65%), Gaps = 4/70 (5%)
Query: 304 NFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKGTLLALL-ISMVSYAMMVLFTG--- 359
+F + IFFPSVTGI AG+N SGDL+D +IP GT+LA++ S+V ++ +VLF
Sbjct: 419 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIE 478
Query: 360 AAALRDASGN 369
LRD G+
Sbjct: 479 GVVLRDKYGD 488
Score = 50.8 bits (116), Expect = 2e-05
Identities = 22/63 (34%), Positives = 40/63 (63%)
Query: 974 LRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRGNHTSVLT 1033
++L E+++ S D+RL+++++P P + S YM +LE+++ L +L VRG V+T
Sbjct: 1023 VKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVIT 1082
Query: 1034 FYS 1036
YS
Sbjct: 1083 IYS 1085
Score = 49.6 bits (113), Expect = 6e-05
Identities = 16/36 (44%), Positives = 25/36 (69%)
Query: 857 GTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIF 892
G +DVWW+ D G+ +LLP+++ Q W C++RIF
Sbjct: 844 GHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIF 879
>BC132670-1|AAI32671.1| 1116|Homo sapiens solute carrier family 12,
(potassium-chloride transporter) member 5 protein.
Length = 1116
Score = 139 bits (336), Expect = 5e-32
Identities = 103/358 (28%), Positives = 157/358 (43%), Gaps = 17/358 (4%)
Query: 363 LRDASGNI---TDLVISNGTVTNYSAV---SQCANSTLFPCKYGMHVDFEIMQLMSAW-G 415
LRDA +I T L I+ + S+V C + K+G V+ ++ AW
Sbjct: 424 LRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPS 483
Query: 416 PFIYA-GCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFSKPYGR-HGEAYRGYXXX 473
P++ G + PRL+QA+ D I P L F +G+ +GE
Sbjct: 484 PWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFG--HGKANGEPTWALLLT 541
Query: 474 XXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAALVRPLGWRPTFKYYNVWVSLA 533
IA L+ +AP++S F+L Y +N L+R WRP F+YY+ +S
Sbjct: 542 ACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFL 601
Query: 534 GFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNWGSSTQAQMYKTALSSAHNLA 593
G +C+ +M + SW +LV + I +Y + YR + WG + A + L
Sbjct: 602 GMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLE 661
Query: 594 RTGEHVKNYWPQLLVL----GGRAHARPPLVDLGSLITKAGSLMIIGDISKEK-LSYKVC 648
H KN+ PQLLVL + P L+ L S + L I+G + + L
Sbjct: 662 EGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQ 721
Query: 649 SARARADNEWLQE-RKVRAFCSLVHGFNFEQGARALIQATGVGKLAPNVLLMGYKSDW 705
+ RA L E KV+ FC +V N G LIQ+ G+G L N +L+G+ +W
Sbjct: 722 AQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNW 779
Score = 115 bits (277), Expect = 8e-25
Identities = 71/221 (32%), Positives = 116/221 (52%), Gaps = 16/221 (7%)
Query: 54 AGWRRKRSLAQLTREALPRMENYRNSKRALKRPSLGELHGDHLITEEGVLIPCLLNIWGV 113
+G +L Q +RE N K+ ++ P +G T GV +PCL NI+GV
Sbjct: 63 SGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRMG--------TFMGVYLPCLQNIFGV 114
Query: 114 MLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVKGGGIYYIISRSLGP 173
+LFLR++WVV AGI S ++ + ++T +SMSAI TNG V GG YY+ISRSLGP
Sbjct: 115 ILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGP 174
Query: 174 EFGASVGIIFAFANAVAASMNTIGFCD-SMNHLLKSLDLQIIDNS-------YNDVRIIG 225
EFG +VG+ F A +M +G + + +L ++ + +++ N++R+ G
Sbjct: 175 EFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYG 234
Query: 226 AIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAV 266
L M + VG+ + +K + ++ +I+ G +
Sbjct: 235 TCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVI 275
Score = 62.1 bits (144), Expect = 1e-08
Identities = 39/105 (37%), Positives = 58/105 (55%), Gaps = 6/105 (5%)
Query: 280 VGLSTSTFVENFNSDFKYSEGMEQNFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKG 339
VGL+ T ++ + + +S+ M F + I+FPSVTGI AG+N SGDL+D +IP G
Sbjct: 377 VGLADGTPID-MDHPYVFSD-MTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTG 434
Query: 340 TLLALLISMVSYAMMVLFTGA----AALRDASGNITDLVISNGTV 380
T+LA+ + Y V+ GA LRD G + + GT+
Sbjct: 435 TILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTL 479
Score = 50.0 bits (114), Expect = 4e-05
Identities = 16/36 (44%), Positives = 25/36 (69%)
Query: 857 GTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIF 892
G++DVWW+ D G+ +LLP+++ W CK+RIF
Sbjct: 824 GSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIF 859
Score = 49.2 bits (112), Expect = 8e-05
Identities = 21/63 (33%), Positives = 40/63 (63%)
Query: 974 LRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRGNHTSVLT 1033
+RL E+++ SRD++L+++++P P + YM +LE+++ L ++ VRG V+T
Sbjct: 1054 VRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGGREVIT 1113
Query: 1034 FYS 1036
YS
Sbjct: 1114 IYS 1116
>BC132668-1|AAI32669.1| 1116|Homo sapiens solute carrier family 12,
(potassium-chloride transporter) member 5 protein.
Length = 1116
Score = 139 bits (336), Expect = 5e-32
Identities = 103/358 (28%), Positives = 157/358 (43%), Gaps = 17/358 (4%)
Query: 363 LRDASGNI---TDLVISNGTVTNYSAV---SQCANSTLFPCKYGMHVDFEIMQLMSAW-G 415
LRDA +I T L I+ + S+V C + K+G V+ ++ AW
Sbjct: 424 LRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPS 483
Query: 416 PFIYA-GCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFSKPYGR-HGEAYRGYXXX 473
P++ G + PRL+QA+ D I P L F +G+ +GE
Sbjct: 484 PWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFG--HGKANGEPTWALLLT 541
Query: 474 XXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAALVRPLGWRPTFKYYNVWVSLA 533
IA L+ +AP++S F+L Y +N L+R WRP F+YY+ +S
Sbjct: 542 ACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFL 601
Query: 534 GFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNWGSSTQAQMYKTALSSAHNLA 593
G +C+ +M + SW +LV + I +Y + YR + WG + A + L
Sbjct: 602 GMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLE 661
Query: 594 RTGEHVKNYWPQLLVL----GGRAHARPPLVDLGSLITKAGSLMIIGDISKEK-LSYKVC 648
H KN+ PQLLVL + P L+ L S + L I+G + + L
Sbjct: 662 EGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQ 721
Query: 649 SARARADNEWLQE-RKVRAFCSLVHGFNFEQGARALIQATGVGKLAPNVLLMGYKSDW 705
+ RA L E KV+ FC +V N G LIQ+ G+G L N +L+G+ +W
Sbjct: 722 AQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNW 779
Score = 115 bits (277), Expect = 8e-25
Identities = 71/221 (32%), Positives = 116/221 (52%), Gaps = 16/221 (7%)
Query: 54 AGWRRKRSLAQLTREALPRMENYRNSKRALKRPSLGELHGDHLITEEGVLIPCLLNIWGV 113
+G +L Q +RE N K+ ++ P +G T GV +PCL NI+GV
Sbjct: 63 SGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRMG--------TFMGVYLPCLQNIFGV 114
Query: 114 MLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVKGGGIYYIISRSLGP 173
+LFLR++WVV AGI S ++ + ++T +SMSAI TNG V GG YY+ISRSLGP
Sbjct: 115 ILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGP 174
Query: 174 EFGASVGIIFAFANAVAASMNTIGFCD-SMNHLLKSLDLQIIDNS-------YNDVRIIG 225
EFG +VG+ F A +M +G + + +L ++ + +++ N++R+ G
Sbjct: 175 EFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYG 234
Query: 226 AIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAV 266
L M + VG+ + +K + ++ +I+ G +
Sbjct: 235 TCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVI 275
Score = 62.1 bits (144), Expect = 1e-08
Identities = 39/105 (37%), Positives = 58/105 (55%), Gaps = 6/105 (5%)
Query: 280 VGLSTSTFVENFNSDFKYSEGMEQNFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKG 339
VGL+ T ++ + + +S+ M F + I+FPSVTGI AG+N SGDL+D +IP G
Sbjct: 377 VGLADGTPID-MDHPYVFSD-MTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTG 434
Query: 340 TLLALLISMVSYAMMVLFTGA----AALRDASGNITDLVISNGTV 380
T+LA+ + Y V+ GA LRD G + + GT+
Sbjct: 435 TILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTL 479
Score = 50.0 bits (114), Expect = 4e-05
Identities = 16/36 (44%), Positives = 25/36 (69%)
Query: 857 GTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIF 892
G++DVWW+ D G+ +LLP+++ W CK+RIF
Sbjct: 824 GSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIF 859
Score = 49.2 bits (112), Expect = 8e-05
Identities = 21/63 (33%), Positives = 40/63 (63%)
Query: 974 LRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRGNHTSVLT 1033
+RL E+++ SRD++L+++++P P + YM +LE+++ L ++ VRG V+T
Sbjct: 1054 VRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGGREVIT 1113
Query: 1034 FYS 1036
YS
Sbjct: 1114 IYS 1116
>BC021193-1|AAH21193.1| 1085|Homo sapiens solute carrier family 12
(potassium/chloride transporters), member 4 protein.
Length = 1085
Score = 139 bits (336), Expect = 5e-32
Identities = 99/358 (27%), Positives = 156/358 (43%), Gaps = 17/358 (4%)
Query: 363 LRDASGNI---TDLVISNGTVTNYSAV---SQCANSTLFPCKYGMHVDFEIMQLMSAW-G 415
LRDA +I T L I ++ +S+V C + KYG V ++ AW
Sbjct: 444 LRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPS 503
Query: 416 PFIYA-GCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFSKPYGR-HGEAYRGYXXX 473
P++ G + PRL+QA+ D I P L F +G+ +GE
Sbjct: 504 PWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFG--HGKVNGEPTWALLLT 561
Query: 474 XXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAALVRPLGWRPTFKYYNVWVSLA 533
IA L+ +AP++S F+L Y +N L+R WRP FKYY+ +S
Sbjct: 562 ALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFL 621
Query: 534 GFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNWGSSTQAQMYKTALSSAHNLA 593
G +C+ +M + SW +LV + I +Y + Y+ + WG + A + L
Sbjct: 622 GMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLE 681
Query: 594 RTGEHVKNYWPQLLV---LGGRAHAR-PPLVDLGSLITKAGSLMIIGDISKEKL--SYKV 647
H KN+ PQLLV L H + P L+ S + L I+G + + SY
Sbjct: 682 EGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGE 741
Query: 648 CSARARADNEWLQERKVRAFCSLVHGFNFEQGARALIQATGVGKLAPNVLLMGYKSDW 705
A + ++ KV+ FC +V +G LIQ+ G+G + N +++G+ W
Sbjct: 742 AQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGW 799
Score = 120 bits (290), Expect = 2e-26
Identities = 67/195 (34%), Positives = 112/195 (57%), Gaps = 16/195 (8%)
Query: 80 KRALKRPSLGELHGDHLITEEGVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSA 139
+RA + PS+G L G V +PCL NI+GV+LFLR++W+V AG+ +L+I+ +
Sbjct: 110 RRAAEAPSMGTLMG--------VYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICC 161
Query: 140 VVCVITTLSMSAICTNGEVKGGGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFC 199
++T +SMSAI TNG V GG Y++ISRSLGPEFG +VG+ F AA+M +G
Sbjct: 162 CCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAI 221
Query: 200 D-SMNHLLKSLDL-------QIIDNSYNDVRIIGAIALFVMCVICAVGMDWESKAQNFLI 251
+ + ++ + + + N++R+ G I L M ++ VG+ + +K + +
Sbjct: 222 EILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFL 281
Query: 252 AIIVGAIVDFVVGAV 266
A ++ +I+ G +
Sbjct: 282 ACVIISILSIYAGGI 296
Score = 60.5 bits (140), Expect = 3e-08
Identities = 33/70 (47%), Positives = 46/70 (65%), Gaps = 4/70 (5%)
Query: 304 NFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKGTLLALL-ISMVSYAMMVLFTG--- 359
+F + IFFPSVTGI AG+N SGDL+D +IP GT+LA++ S+V ++ +VLF
Sbjct: 419 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIE 478
Query: 360 AAALRDASGN 369
LRD G+
Sbjct: 479 GVVLRDKYGD 488
Score = 50.8 bits (116), Expect = 2e-05
Identities = 22/63 (34%), Positives = 40/63 (63%)
Query: 974 LRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRGNHTSVLT 1033
++L E+++ S D+RL+++++P P + S YM +LE+++ L +L VRG V+T
Sbjct: 1023 VKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVIT 1082
Query: 1034 FYS 1036
YS
Sbjct: 1083 IYS 1085
Score = 49.6 bits (113), Expect = 6e-05
Identities = 16/36 (44%), Positives = 25/36 (69%)
Query: 857 GTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIF 892
G +DVWW+ D G+ +LLP+++ Q W C++RIF
Sbjct: 844 GHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIF 879
>AL162458-7|CAH74054.2| 1116|Homo sapiens solute carrier family 12,
(potassium-chloride transporter) member 5 protein.
Length = 1116
Score = 139 bits (336), Expect = 5e-32
Identities = 103/358 (28%), Positives = 157/358 (43%), Gaps = 17/358 (4%)
Query: 363 LRDASGNI---TDLVISNGTVTNYSAV---SQCANSTLFPCKYGMHVDFEIMQLMSAW-G 415
LRDA +I T L I+ + S+V C + K+G V+ ++ AW
Sbjct: 424 LRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPS 483
Query: 416 PFIYA-GCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFSKPYGR-HGEAYRGYXXX 473
P++ G + PRL+QA+ D I P L F +G+ +GE
Sbjct: 484 PWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFG--HGKANGEPTWALLLT 541
Query: 474 XXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAALVRPLGWRPTFKYYNVWVSLA 533
IA L+ +AP++S F+L Y +N L+R WRP F+YY+ +S
Sbjct: 542 ACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFL 601
Query: 534 GFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNWGSSTQAQMYKTALSSAHNLA 593
G +C+ +M + SW +LV + I +Y + YR + WG + A + L
Sbjct: 602 GMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLE 661
Query: 594 RTGEHVKNYWPQLLVL----GGRAHARPPLVDLGSLITKAGSLMIIGDISKEK-LSYKVC 648
H KN+ PQLLVL + P L+ L S + L I+G + + L
Sbjct: 662 EGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQ 721
Query: 649 SARARADNEWLQE-RKVRAFCSLVHGFNFEQGARALIQATGVGKLAPNVLLMGYKSDW 705
+ RA L E KV+ FC +V N G LIQ+ G+G L N +L+G+ +W
Sbjct: 722 AQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNW 779
Score = 115 bits (277), Expect = 8e-25
Identities = 71/221 (32%), Positives = 116/221 (52%), Gaps = 16/221 (7%)
Query: 54 AGWRRKRSLAQLTREALPRMENYRNSKRALKRPSLGELHGDHLITEEGVLIPCLLNIWGV 113
+G +L Q +RE N K+ ++ P +G T GV +PCL NI+GV
Sbjct: 63 SGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRMG--------TFMGVYLPCLQNIFGV 114
Query: 114 MLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVKGGGIYYIISRSLGP 173
+LFLR++WVV AGI S ++ + ++T +SMSAI TNG V GG YY+ISRSLGP
Sbjct: 115 ILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGP 174
Query: 174 EFGASVGIIFAFANAVAASMNTIGFCD-SMNHLLKSLDLQIIDNS-------YNDVRIIG 225
EFG +VG+ F A +M +G + + +L ++ + +++ N++R+ G
Sbjct: 175 EFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYG 234
Query: 226 AIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAV 266
L M + VG+ + +K + ++ +I+ G +
Sbjct: 235 TCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVI 275
Score = 62.1 bits (144), Expect = 1e-08
Identities = 39/105 (37%), Positives = 58/105 (55%), Gaps = 6/105 (5%)
Query: 280 VGLSTSTFVENFNSDFKYSEGMEQNFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKG 339
VGL+ T ++ + + +S+ M F + I+FPSVTGI AG+N SGDL+D +IP G
Sbjct: 377 VGLADGTPID-MDHPYVFSD-MTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTG 434
Query: 340 TLLALLISMVSYAMMVLFTGA----AALRDASGNITDLVISNGTV 380
T+LA+ + Y V+ GA LRD G + + GT+
Sbjct: 435 TILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTL 479
Score = 50.0 bits (114), Expect = 4e-05
Identities = 16/36 (44%), Positives = 25/36 (69%)
Query: 857 GTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIF 892
G++DVWW+ D G+ +LLP+++ W CK+RIF
Sbjct: 824 GSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIF 859
Score = 49.2 bits (112), Expect = 8e-05
Identities = 21/63 (33%), Positives = 40/63 (63%)
Query: 974 LRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRGNHTSVLT 1033
+RL E+++ SRD++L+++++P P + YM +LE+++ L ++ VRG V+T
Sbjct: 1054 VRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGGREVIT 1113
Query: 1034 FYS 1036
YS
Sbjct: 1114 IYS 1116
>AF208159-1|AAG43493.1| 1116|Homo sapiens electroneutral
potassium-chloride cotransporter KCC2 protein.
Length = 1116
Score = 139 bits (336), Expect = 5e-32
Identities = 103/358 (28%), Positives = 157/358 (43%), Gaps = 17/358 (4%)
Query: 363 LRDASGNI---TDLVISNGTVTNYSAV---SQCANSTLFPCKYGMHVDFEIMQLMSAW-G 415
LRDA +I T L I+ + S+V C + K+G V+ ++ AW
Sbjct: 424 LRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPS 483
Query: 416 PFIYA-GCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFSKPYGR-HGEAYRGYXXX 473
P++ G + PRL+QA+ D I P L F +G+ +GE
Sbjct: 484 PWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFG--HGKANGEPTWALLLT 541
Query: 474 XXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAALVRPLGWRPTFKYYNVWVSLA 533
IA L+ +AP++S F+L Y +N L+R WRP F+YY+ +S
Sbjct: 542 ACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFL 601
Query: 534 GFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNWGSSTQAQMYKTALSSAHNLA 593
G +C+ +M + SW +LV + I +Y + YR + WG + A + L
Sbjct: 602 GMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLE 661
Query: 594 RTGEHVKNYWPQLLVL----GGRAHARPPLVDLGSLITKAGSLMIIGDISKEK-LSYKVC 648
H KN+ PQLLVL + P L+ L S + L I+G + + L
Sbjct: 662 EGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQ 721
Query: 649 SARARADNEWLQE-RKVRAFCSLVHGFNFEQGARALIQATGVGKLAPNVLLMGYKSDW 705
+ RA L E KV+ FC +V N G LIQ+ G+G L N +L+G+ +W
Sbjct: 722 AQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNW 779
Score = 115 bits (277), Expect = 8e-25
Identities = 71/221 (32%), Positives = 116/221 (52%), Gaps = 16/221 (7%)
Query: 54 AGWRRKRSLAQLTREALPRMENYRNSKRALKRPSLGELHGDHLITEEGVLIPCLLNIWGV 113
+G +L Q +RE N K+ ++ P +G T GV +PCL NI+GV
Sbjct: 63 SGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRMG--------TFMGVYLPCLQNIFGV 114
Query: 114 MLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVKGGGIYYIISRSLGP 173
+LFLR++WVV AGI S ++ + ++T +SMSAI TNG V GG YY+ISRSLGP
Sbjct: 115 ILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGP 174
Query: 174 EFGASVGIIFAFANAVAASMNTIGFCD-SMNHLLKSLDLQIIDNS-------YNDVRIIG 225
EFG +VG+ F A +M +G + + +L ++ + +++ N++R+ G
Sbjct: 175 EFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYG 234
Query: 226 AIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAV 266
L M + VG+ + +K + ++ +I+ G +
Sbjct: 235 TCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVI 275
Score = 62.1 bits (144), Expect = 1e-08
Identities = 39/105 (37%), Positives = 58/105 (55%), Gaps = 6/105 (5%)
Query: 280 VGLSTSTFVENFNSDFKYSEGMEQNFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKG 339
VGL+ T ++ + + +S+ M F + I+FPSVTGI AG+N SGDL+D +IP G
Sbjct: 377 VGLADGTPID-MDHPYVFSD-MTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTG 434
Query: 340 TLLALLISMVSYAMMVLFTGA----AALRDASGNITDLVISNGTV 380
T+LA+ + Y V+ GA LRD G + + GT+
Sbjct: 435 TILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTL 479
Score = 50.0 bits (114), Expect = 4e-05
Identities = 16/36 (44%), Positives = 25/36 (69%)
Query: 857 GTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIF 892
G++DVWW+ D G+ +LLP+++ W CK+RIF
Sbjct: 824 GSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIF 859
Score = 49.2 bits (112), Expect = 8e-05
Identities = 21/63 (33%), Positives = 40/63 (63%)
Query: 974 LRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRGNHTSVLT 1033
+RL E+++ SRD++L+++++P P + YM +LE+++ L ++ VRG V+T
Sbjct: 1054 VRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGGREVIT 1113
Query: 1034 FYS 1036
YS
Sbjct: 1114 IYS 1116
>AF054506-1|AAC39685.1| 1068|Homo sapiens erythroid K:Cl
cotransporter splicing isoform 2 protein.
Length = 1068
Score = 139 bits (336), Expect = 5e-32
Identities = 99/358 (27%), Positives = 156/358 (43%), Gaps = 17/358 (4%)
Query: 363 LRDASGNI---TDLVISNGTVTNYSAV---SQCANSTLFPCKYGMHVDFEIMQLMSAW-G 415
LRDA +I T L I ++ +S+V C + KYG V ++ AW
Sbjct: 444 LRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPS 503
Query: 416 PFIYA-GCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFSKPYGR-HGEAYRGYXXX 473
P++ G + PRL+QA+ D I P L F +G+ +GE
Sbjct: 504 PWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFG--HGKVNGEPTWALLLT 561
Query: 474 XXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAALVRPLGWRPTFKYYNVWVSLA 533
IA L+ +AP++S F+L Y +N L+R WRP FKYY+ +S
Sbjct: 562 ALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFL 621
Query: 534 GFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNWGSSTQAQMYKTALSSAHNLA 593
G +C+ +M + SW +LV + I +Y + Y+ + WG + A + L
Sbjct: 622 GMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLE 681
Query: 594 RTGEHVKNYWPQLLV---LGGRAHAR-PPLVDLGSLITKAGSLMIIGDISKEKL--SYKV 647
H KN+ PQLLV L H + P L+ S + L I+G + + SY
Sbjct: 682 EGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGE 741
Query: 648 CSARARADNEWLQERKVRAFCSLVHGFNFEQGARALIQATGVGKLAPNVLLMGYKSDW 705
A + ++ KV+ FC +V +G LIQ+ G+G + N +++G+ W
Sbjct: 742 AQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGW 799
Score = 120 bits (290), Expect = 2e-26
Identities = 67/195 (34%), Positives = 112/195 (57%), Gaps = 16/195 (8%)
Query: 80 KRALKRPSLGELHGDHLITEEGVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSA 139
+RA + PS+G L G V +PCL NI+GV+LFLR++W+V AG+ +L+I+ +
Sbjct: 110 RRAAEAPSMGTLMG--------VYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICC 161
Query: 140 VVCVITTLSMSAICTNGEVKGGGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFC 199
++T +SMSAI TNG V GG Y++ISRSLGPEFG +VG+ F AA+M +G
Sbjct: 162 CCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAI 221
Query: 200 D-SMNHLLKSLDL-------QIIDNSYNDVRIIGAIALFVMCVICAVGMDWESKAQNFLI 251
+ + ++ + + + N++R+ G I L M ++ VG+ + +K + +
Sbjct: 222 EILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFL 281
Query: 252 AIIVGAIVDFVVGAV 266
A ++ +I+ G +
Sbjct: 282 ACVIISILSIYAGGI 296
Score = 60.5 bits (140), Expect = 3e-08
Identities = 33/70 (47%), Positives = 46/70 (65%), Gaps = 4/70 (5%)
Query: 304 NFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKGTLLALL-ISMVSYAMMVLFTG--- 359
+F + IFFPSVTGI AG+N SGDL+D +IP GT+LA++ S+V ++ +VLF
Sbjct: 419 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIE 478
Query: 360 AAALRDASGN 369
LRD G+
Sbjct: 479 GVVLRDKYGD 488
Score = 49.6 bits (113), Expect = 6e-05
Identities = 16/36 (44%), Positives = 25/36 (69%)
Query: 857 GTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIF 892
G +DVWW+ D G+ +LLP+++ Q W C++RIF
Sbjct: 844 GHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIF 879
>AF054505-1|AAC39684.1| 1011|Homo sapiens erythroid K:Cl
cotransporter splicing isoform 1 protein.
Length = 1011
Score = 139 bits (336), Expect = 5e-32
Identities = 99/358 (27%), Positives = 156/358 (43%), Gaps = 17/358 (4%)
Query: 363 LRDASGNI---TDLVISNGTVTNYSAV---SQCANSTLFPCKYGMHVDFEIMQLMSAW-G 415
LRDA +I T L I ++ +S+V C + KYG V ++ AW
Sbjct: 444 LRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPS 503
Query: 416 PFIYA-GCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFSKPYGR-HGEAYRGYXXX 473
P++ G + PRL+QA+ D I P L F +G+ +GE
Sbjct: 504 PWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFG--HGKVNGEPTWALLLT 561
Query: 474 XXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAALVRPLGWRPTFKYYNVWVSLA 533
IA L+ +AP++S F+L Y +N L+R WRP FKYY+ +S
Sbjct: 562 ALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFL 621
Query: 534 GFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNWGSSTQAQMYKTALSSAHNLA 593
G +C+ +M + SW +LV + I +Y + Y+ + WG + A + L
Sbjct: 622 GMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLE 681
Query: 594 RTGEHVKNYWPQLLV---LGGRAHAR-PPLVDLGSLITKAGSLMIIGDISKEKL--SYKV 647
H KN+ PQLLV L H + P L+ S + L I+G + + SY
Sbjct: 682 EGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGE 741
Query: 648 CSARARADNEWLQERKVRAFCSLVHGFNFEQGARALIQATGVGKLAPNVLLMGYKSDW 705
A + ++ KV+ FC +V +G LIQ+ G+G + N +++G+ W
Sbjct: 742 AQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGW 799
Score = 120 bits (290), Expect = 2e-26
Identities = 67/195 (34%), Positives = 112/195 (57%), Gaps = 16/195 (8%)
Query: 80 KRALKRPSLGELHGDHLITEEGVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSA 139
+RA + PS+G L G V +PCL NI+GV+LFLR++W+V AG+ +L+I+ +
Sbjct: 110 RRAAEAPSMGTLMG--------VYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICC 161
Query: 140 VVCVITTLSMSAICTNGEVKGGGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFC 199
++T +SMSAI TNG V GG Y++ISRSLGPEFG +VG+ F AA+M +G
Sbjct: 162 CCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAI 221
Query: 200 D-SMNHLLKSLDL-------QIIDNSYNDVRIIGAIALFVMCVICAVGMDWESKAQNFLI 251
+ + ++ + + + N++R+ G I L M ++ VG+ + +K + +
Sbjct: 222 EILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFL 281
Query: 252 AIIVGAIVDFVVGAV 266
A ++ +I+ G +
Sbjct: 282 ACVIISILSIYAGGI 296
Score = 60.5 bits (140), Expect = 3e-08
Identities = 33/70 (47%), Positives = 46/70 (65%), Gaps = 4/70 (5%)
Query: 304 NFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKGTLLALL-ISMVSYAMMVLFTG--- 359
+F + IFFPSVTGI AG+N SGDL+D +IP GT+LA++ S+V ++ +VLF
Sbjct: 419 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIE 478
Query: 360 AAALRDASGN 369
LRD G+
Sbjct: 479 GVVLRDKYGD 488
Score = 49.6 bits (113), Expect = 6e-05
Identities = 16/36 (44%), Positives = 25/36 (69%)
Query: 857 GTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIF 892
G +DVWW+ D G+ +LLP+++ Q W C++RIF
Sbjct: 844 GHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIF 879
>AF047338-1|AAC32815.1| 1085|Homo sapiens erythroid K:Cl
cotransporter protein.
Length = 1085
Score = 139 bits (336), Expect = 5e-32
Identities = 99/358 (27%), Positives = 156/358 (43%), Gaps = 17/358 (4%)
Query: 363 LRDASGNI---TDLVISNGTVTNYSAV---SQCANSTLFPCKYGMHVDFEIMQLMSAW-G 415
LRDA +I T L I ++ +S+V C + KYG V ++ AW
Sbjct: 444 LRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPS 503
Query: 416 PFIYA-GCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFSKPYGR-HGEAYRGYXXX 473
P++ G + PRL+QA+ D I P L F +G+ +GE
Sbjct: 504 PWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFG--HGKVNGEPTWALLLT 561
Query: 474 XXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAALVRPLGWRPTFKYYNVWVSLA 533
IA L+ +AP++S F+L Y +N L+R WRP FKYY+ +S
Sbjct: 562 ALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFL 621
Query: 534 GFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNWGSSTQAQMYKTALSSAHNLA 593
G +C+ +M + SW +LV + I +Y + Y+ + WG + A + L
Sbjct: 622 GMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLE 681
Query: 594 RTGEHVKNYWPQLLV---LGGRAHAR-PPLVDLGSLITKAGSLMIIGDISKEKL--SYKV 647
H KN+ PQLLV L H + P L+ S + L I+G + + SY
Sbjct: 682 EGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGE 741
Query: 648 CSARARADNEWLQERKVRAFCSLVHGFNFEQGARALIQATGVGKLAPNVLLMGYKSDW 705
A + ++ KV+ FC +V +G LIQ+ G+G + N +++G+ W
Sbjct: 742 AQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGW 799
Score = 120 bits (290), Expect = 2e-26
Identities = 67/195 (34%), Positives = 112/195 (57%), Gaps = 16/195 (8%)
Query: 80 KRALKRPSLGELHGDHLITEEGVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSA 139
+RA + PS+G L G V +PCL NI+GV+LFLR++W+V AG+ +L+I+ +
Sbjct: 110 RRAAEAPSMGTLMG--------VYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICC 161
Query: 140 VVCVITTLSMSAICTNGEVKGGGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFC 199
++T +SMSAI TNG V GG Y++ISRSLGPEFG +VG+ F AA+M +G
Sbjct: 162 CCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAI 221
Query: 200 D-SMNHLLKSLDL-------QIIDNSYNDVRIIGAIALFVMCVICAVGMDWESKAQNFLI 251
+ + ++ + + + N++R+ G I L M ++ VG+ + +K + +
Sbjct: 222 EILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFL 281
Query: 252 AIIVGAIVDFVVGAV 266
A ++ +I+ G +
Sbjct: 282 ACVIISILSIYAGGI 296
Score = 60.5 bits (140), Expect = 3e-08
Identities = 33/70 (47%), Positives = 46/70 (65%), Gaps = 4/70 (5%)
Query: 304 NFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKGTLLALL-ISMVSYAMMVLFTG--- 359
+F + IFFPSVTGI AG+N SGDL+D +IP GT+LA++ S+V ++ +VLF
Sbjct: 419 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIE 478
Query: 360 AAALRDASGN 369
LRD G+
Sbjct: 479 GVVLRDKYGD 488
Score = 50.8 bits (116), Expect = 2e-05
Identities = 22/63 (34%), Positives = 40/63 (63%)
Query: 974 LRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRGNHTSVLT 1033
++L E+++ S D+RL+++++P P + S YM +LE+++ L +L VRG V+T
Sbjct: 1023 VKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVIT 1082
Query: 1034 FYS 1036
YS
Sbjct: 1083 IYS 1085
Score = 49.6 bits (113), Expect = 6e-05
Identities = 16/36 (44%), Positives = 25/36 (69%)
Query: 857 GTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIF 892
G +DVWW+ D G+ +LLP+++ Q W C++RIF
Sbjct: 844 GHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIF 879
>AB033002-1|BAA86490.1| 1101|Homo sapiens KIAA1176 protein protein.
Length = 1101
Score = 139 bits (336), Expect = 5e-32
Identities = 103/358 (28%), Positives = 157/358 (43%), Gaps = 17/358 (4%)
Query: 363 LRDASGNI---TDLVISNGTVTNYSAV---SQCANSTLFPCKYGMHVDFEIMQLMSAW-G 415
LRDA +I T L I+ + S+V C + K+G V+ ++ AW
Sbjct: 416 LRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPS 475
Query: 416 PFIYA-GCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFSKPYGR-HGEAYRGYXXX 473
P++ G + PRL+QA+ D I P L F +G+ +GE
Sbjct: 476 PWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFG--HGKANGEPTWALLLT 533
Query: 474 XXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAALVRPLGWRPTFKYYNVWVSLA 533
IA L+ +AP++S F+L Y +N L+R WRP F+YY+ +S
Sbjct: 534 ACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFL 593
Query: 534 GFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNWGSSTQAQMYKTALSSAHNLA 593
G +C+ +M + SW +LV + I +Y + YR + WG + A + L
Sbjct: 594 GMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLE 653
Query: 594 RTGEHVKNYWPQLLVL----GGRAHARPPLVDLGSLITKAGSLMIIGDISKEK-LSYKVC 648
H KN+ PQLLVL + P L+ L S + L I+G + + L
Sbjct: 654 EGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQ 713
Query: 649 SARARADNEWLQE-RKVRAFCSLVHGFNFEQGARALIQATGVGKLAPNVLLMGYKSDW 705
+ RA L E KV+ FC +V N G LIQ+ G+G L N +L+G+ +W
Sbjct: 714 AQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNW 771
Score = 115 bits (277), Expect = 8e-25
Identities = 71/221 (32%), Positives = 116/221 (52%), Gaps = 16/221 (7%)
Query: 54 AGWRRKRSLAQLTREALPRMENYRNSKRALKRPSLGELHGDHLITEEGVLIPCLLNIWGV 113
+G +L Q +RE N K+ ++ P +G T GV +PCL NI+GV
Sbjct: 55 SGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRMG--------TFMGVYLPCLQNIFGV 106
Query: 114 MLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVKGGGIYYIISRSLGP 173
+LFLR++WVV AGI S ++ + ++T +SMSAI TNG V GG YY+ISRSLGP
Sbjct: 107 ILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGP 166
Query: 174 EFGASVGIIFAFANAVAASMNTIGFCD-SMNHLLKSLDLQIIDNS-------YNDVRIIG 225
EFG +VG+ F A +M +G + + +L ++ + +++ N++R+ G
Sbjct: 167 EFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYG 226
Query: 226 AIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAV 266
L M + VG+ + +K + ++ +I+ G +
Sbjct: 227 TCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVI 267
Score = 62.1 bits (144), Expect = 1e-08
Identities = 39/105 (37%), Positives = 58/105 (55%), Gaps = 6/105 (5%)
Query: 280 VGLSTSTFVENFNSDFKYSEGMEQNFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKG 339
VGL+ T ++ + + +S+ M F + I+FPSVTGI AG+N SGDL+D +IP G
Sbjct: 369 VGLADGTPID-MDHPYVFSD-MTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTG 426
Query: 340 TLLALLISMVSYAMMVLFTGA----AALRDASGNITDLVISNGTV 380
T+LA+ + Y V+ GA LRD G + + GT+
Sbjct: 427 TILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTL 471
Score = 50.0 bits (114), Expect = 4e-05
Identities = 16/36 (44%), Positives = 25/36 (69%)
Query: 857 GTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIF 892
G++DVWW+ D G+ +LLP+++ W CK+RIF
Sbjct: 816 GSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIF 851
Score = 37.9 bits (84), Expect = 0.19
Identities = 18/54 (33%), Positives = 37/54 (68%), Gaps = 2/54 (3%)
Query: 974 LRLRELLLANSRDSRLIVMSLP-MPRKGSVSAPLYMAWLEMMSRDLPPMLFVRG 1026
+RL E+++ SRD++L+++++P +PR + YM +LE+++ L ++ VRG
Sbjct: 1046 VRLNEVIVKKSRDAKLVLLNMPGLPRNRNGDEN-YMEFLEVLTEHLDRVMLVRG 1098
>DQ138323-1|ABA02873.1| 1141|Homo sapiens potassium chloride
cotransporter KCC3a-S3 protein.
Length = 1141
Score = 134 bits (323), Expect = 2e-30
Identities = 90/351 (25%), Positives = 148/351 (42%), Gaps = 11/351 (3%)
Query: 380 VTNYSAVSQCANSTLFPCKYGMHVDFEIMQLMSAW-GPFIYA-GCWXXXXXXXXXXXXXV 437
++N C + K+G V ++ +W P++ G +
Sbjct: 523 LSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGA 582
Query: 438 PRLIQALGVDRIYPGLIFFSKPYGRHGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFY 497
PRL+QA+ D I P L F +GE IA L+ +AP++S F+
Sbjct: 583 PRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTAAIAELGILIASLDLVAPILSMFF 641
Query: 498 LASYALINFCTFHAALVRPLGWRPTFKYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIF 557
L Y +N L+R WRP F+YY+ +S G +C+ +M + SW ++V + I
Sbjct: 642 LMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIA 701
Query: 558 FTLYLIVHYRNPDVNWGSSTQAQMYKTALSSAHNLARTGEHVKNYWPQLLV---LGGRAH 614
+Y + Y+ + WG + A + L H KN+ PQLLV L H
Sbjct: 702 GMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLH 761
Query: 615 AR-PPLVDLGSLITKAGSLMIIGDISKEKL--SYKVCSARARADNEWLQERKVRAFCSLV 671
+ P L+ S + L I+G + +Y A + ++ KV+ FC LV
Sbjct: 762 VKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLV 821
Query: 672 HGFNFEQGARALIQATGVGKLAPNVLLMGYKSDWTTASAEDLVAYFNVLHT 722
+G LIQ+ G+G + N ++MG+ + W +ED A+ + T
Sbjct: 822 VAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGW--RQSEDARAWKTFIGT 870
Score = 117 bits (281), Expect = 3e-25
Identities = 60/174 (34%), Positives = 104/174 (59%), Gaps = 8/174 (4%)
Query: 101 GVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVKG 160
GV +PCL NI+GV+LFLR++WVV AG+ + I+ + ++T +SMSAI TNG V
Sbjct: 181 GVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPA 240
Query: 161 GGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFCD-SMNHLLKSLDLQIIDNS-- 217
GG Y++ISR+LGPEFG +VG+ F AA+M +G + + +++ + D++
Sbjct: 241 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 300
Query: 218 -----YNDVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAV 266
N++R+ G L +M ++ +G+ + +K + +A ++ +I+ GA+
Sbjct: 301 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAI 354
Score = 61.7 bits (143), Expect = 1e-08
Identities = 36/82 (43%), Positives = 48/82 (58%), Gaps = 4/82 (4%)
Query: 304 NFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKGTLLALLISMVSYAMMVLFTGA--- 360
+F + IFFPSVTGI AG+N SGDLKD +IP GT+LA+L + Y V+ GA
Sbjct: 475 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 534
Query: 361 -AALRDASGNITDLVISNGTVT 381
LRD G+ + GT++
Sbjct: 535 GVVLRDKFGDAVKGNLVVGTLS 556
Score = 50.0 bits (114), Expect = 4e-05
Identities = 16/36 (44%), Positives = 24/36 (66%)
Query: 857 GTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIF 892
G +DVWW+ D G+ +LLP+++ Q W C +RIF
Sbjct: 900 GNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIF 935
Score = 46.0 bits (104), Expect = 7e-04
Identities = 19/63 (30%), Positives = 40/63 (63%)
Query: 974 LRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRGNHTSVLT 1033
++L E+++ S +++L+++++P P + YM +LE+++ L +L VRG + V+T
Sbjct: 1079 VKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVIT 1138
Query: 1034 FYS 1036
YS
Sbjct: 1139 IYS 1141
>BC126243-1|AAI26244.1| 1099|Homo sapiens solute carrier family 12
(potassium/chloride transporters), member 6 protein.
Length = 1099
Score = 134 bits (323), Expect = 2e-30
Identities = 90/351 (25%), Positives = 148/351 (42%), Gaps = 11/351 (3%)
Query: 380 VTNYSAVSQCANSTLFPCKYGMHVDFEIMQLMSAW-GPFIYA-GCWXXXXXXXXXXXXXV 437
++N C + K+G V ++ +W P++ G +
Sbjct: 481 LSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGA 540
Query: 438 PRLIQALGVDRIYPGLIFFSKPYGRHGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFY 497
PRL+QA+ D I P L F +GE IA L+ +AP++S F+
Sbjct: 541 PRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTAAIAELGILIASLDLVAPILSMFF 599
Query: 498 LASYALINFCTFHAALVRPLGWRPTFKYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIF 557
L Y +N L+R WRP F+YY+ +S G +C+ +M + SW ++V + I
Sbjct: 600 LMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIA 659
Query: 558 FTLYLIVHYRNPDVNWGSSTQAQMYKTALSSAHNLARTGEHVKNYWPQLLV---LGGRAH 614
+Y + Y+ + WG + A + L H KN+ PQLLV L H
Sbjct: 660 GMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLH 719
Query: 615 AR-PPLVDLGSLITKAGSLMIIGDISKEKL--SYKVCSARARADNEWLQERKVRAFCSLV 671
+ P L+ S + L I+G + +Y A + ++ KV+ FC LV
Sbjct: 720 VKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLV 779
Query: 672 HGFNFEQGARALIQATGVGKLAPNVLLMGYKSDWTTASAEDLVAYFNVLHT 722
+G LIQ+ G+G + N ++MG+ + W +ED A+ + T
Sbjct: 780 VAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGW--RQSEDARAWKTFIGT 828
Score = 117 bits (281), Expect = 3e-25
Identities = 60/174 (34%), Positives = 104/174 (59%), Gaps = 8/174 (4%)
Query: 101 GVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVKG 160
GV +PCL NI+GV+LFLR++WVV AG+ + I+ + ++T +SMSAI TNG V
Sbjct: 139 GVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPA 198
Query: 161 GGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFCD-SMNHLLKSLDLQIIDNS-- 217
GG Y++ISR+LGPEFG +VG+ F AA+M +G + + +++ + D++
Sbjct: 199 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 258
Query: 218 -----YNDVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAV 266
N++R+ G L +M ++ +G+ + +K + +A ++ +I+ GA+
Sbjct: 259 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAI 312
Score = 61.7 bits (143), Expect = 1e-08
Identities = 36/82 (43%), Positives = 48/82 (58%), Gaps = 4/82 (4%)
Query: 304 NFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKGTLLALLISMVSYAMMVLFTGA--- 360
+F + IFFPSVTGI AG+N SGDLKD +IP GT+LA+L + Y V+ GA
Sbjct: 433 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 492
Query: 361 -AALRDASGNITDLVISNGTVT 381
LRD G+ + GT++
Sbjct: 493 GVVLRDKFGDAVKGNLVVGTLS 514
Score = 50.0 bits (114), Expect = 4e-05
Identities = 16/36 (44%), Positives = 24/36 (66%)
Query: 857 GTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIF 892
G +DVWW+ D G+ +LLP+++ Q W C +RIF
Sbjct: 858 GNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIF 893
Score = 46.0 bits (104), Expect = 7e-04
Identities = 19/63 (30%), Positives = 40/63 (63%)
Query: 974 LRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRGNHTSVLT 1033
++L E+++ S +++L+++++P P + YM +LE+++ L +L VRG + V+T
Sbjct: 1037 VKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVIT 1096
Query: 1034 FYS 1036
YS
Sbjct: 1097 IYS 1099
>BC126241-1|AAI26242.1| 1099|Homo sapiens solute carrier family 12
(potassium/chloride transporters), member 6 protein.
Length = 1099
Score = 134 bits (323), Expect = 2e-30
Identities = 90/351 (25%), Positives = 148/351 (42%), Gaps = 11/351 (3%)
Query: 380 VTNYSAVSQCANSTLFPCKYGMHVDFEIMQLMSAW-GPFIYA-GCWXXXXXXXXXXXXXV 437
++N C + K+G V ++ +W P++ G +
Sbjct: 481 LSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGA 540
Query: 438 PRLIQALGVDRIYPGLIFFSKPYGRHGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFY 497
PRL+QA+ D I P L F +GE IA L+ +AP++S F+
Sbjct: 541 PRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTAAIAELGILIASLDLVAPILSMFF 599
Query: 498 LASYALINFCTFHAALVRPLGWRPTFKYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIF 557
L Y +N L+R WRP F+YY+ +S G +C+ +M + SW ++V + I
Sbjct: 600 LMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIA 659
Query: 558 FTLYLIVHYRNPDVNWGSSTQAQMYKTALSSAHNLARTGEHVKNYWPQLLV---LGGRAH 614
+Y + Y+ + WG + A + L H KN+ PQLLV L H
Sbjct: 660 GMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLH 719
Query: 615 AR-PPLVDLGSLITKAGSLMIIGDISKEKL--SYKVCSARARADNEWLQERKVRAFCSLV 671
+ P L+ S + L I+G + +Y A + ++ KV+ FC LV
Sbjct: 720 VKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLV 779
Query: 672 HGFNFEQGARALIQATGVGKLAPNVLLMGYKSDWTTASAEDLVAYFNVLHT 722
+G LIQ+ G+G + N ++MG+ + W +ED A+ + T
Sbjct: 780 VAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGW--RQSEDARAWKTFIGT 828
Score = 117 bits (281), Expect = 3e-25
Identities = 60/174 (34%), Positives = 104/174 (59%), Gaps = 8/174 (4%)
Query: 101 GVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVKG 160
GV +PCL NI+GV+LFLR++WVV AG+ + I+ + ++T +SMSAI TNG V
Sbjct: 139 GVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPA 198
Query: 161 GGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFCD-SMNHLLKSLDLQIIDNS-- 217
GG Y++ISR+LGPEFG +VG+ F AA+M +G + + +++ + D++
Sbjct: 199 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 258
Query: 218 -----YNDVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAV 266
N++R+ G L +M ++ +G+ + +K + +A ++ +I+ GA+
Sbjct: 259 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAI 312
Score = 61.7 bits (143), Expect = 1e-08
Identities = 36/82 (43%), Positives = 48/82 (58%), Gaps = 4/82 (4%)
Query: 304 NFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKGTLLALLISMVSYAMMVLFTGA--- 360
+F + IFFPSVTGI AG+N SGDLKD +IP GT+LA+L + Y V+ GA
Sbjct: 433 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 492
Query: 361 -AALRDASGNITDLVISNGTVT 381
LRD G+ + GT++
Sbjct: 493 GVVLRDKFGDAVKGNLVVGTLS 514
Score = 50.0 bits (114), Expect = 4e-05
Identities = 16/36 (44%), Positives = 24/36 (66%)
Query: 857 GTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIF 892
G +DVWW+ D G+ +LLP+++ Q W C +RIF
Sbjct: 858 GNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIF 893
Score = 46.0 bits (104), Expect = 7e-04
Identities = 19/63 (30%), Positives = 40/63 (63%)
Query: 974 LRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRGNHTSVLT 1033
++L E+++ S +++L+++++P P + YM +LE+++ L +L VRG + V+T
Sbjct: 1037 VKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVIT 1096
Query: 1034 FYS 1036
YS
Sbjct: 1097 IYS 1099
>BC070107-1|AAH70107.2| 1091|Homo sapiens solute carrier family 12
(potassium/chloride transporters), member 6 protein.
Length = 1091
Score = 134 bits (323), Expect = 2e-30
Identities = 90/351 (25%), Positives = 148/351 (42%), Gaps = 11/351 (3%)
Query: 380 VTNYSAVSQCANSTLFPCKYGMHVDFEIMQLMSAW-GPFIYA-GCWXXXXXXXXXXXXXV 437
++N C + K+G V ++ +W P++ G +
Sbjct: 473 LSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGA 532
Query: 438 PRLIQALGVDRIYPGLIFFSKPYGRHGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFY 497
PRL+QA+ D I P L F +GE IA L+ +AP++S F+
Sbjct: 533 PRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTAAIAELGILIASLDLVAPILSMFF 591
Query: 498 LASYALINFCTFHAALVRPLGWRPTFKYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIF 557
L Y +N L+R WRP F+YY+ +S G +C+ +M + SW ++V + I
Sbjct: 592 LMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIA 651
Query: 558 FTLYLIVHYRNPDVNWGSSTQAQMYKTALSSAHNLARTGEHVKNYWPQLLV---LGGRAH 614
+Y + Y+ + WG + A + L H KN+ PQLLV L H
Sbjct: 652 GMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLH 711
Query: 615 AR-PPLVDLGSLITKAGSLMIIGDISKEKL--SYKVCSARARADNEWLQERKVRAFCSLV 671
+ P L+ S + L I+G + +Y A + ++ KV+ FC LV
Sbjct: 712 VKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLV 771
Query: 672 HGFNFEQGARALIQATGVGKLAPNVLLMGYKSDWTTASAEDLVAYFNVLHT 722
+G LIQ+ G+G + N ++MG+ + W +ED A+ + T
Sbjct: 772 VAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGW--RQSEDARAWKTFIGT 820
Score = 115 bits (276), Expect = 1e-24
Identities = 60/174 (34%), Positives = 103/174 (59%), Gaps = 8/174 (4%)
Query: 101 GVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVKG 160
GV PCL NI+GV+LFLR++WVV AG+ + I+ + ++T +SMSAI TNG V
Sbjct: 131 GVYPPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPA 190
Query: 161 GGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFCD-SMNHLLKSLDLQIIDNS-- 217
GG Y++ISR+LGPEFG +VG+ F AA+M +G + + +++ + D++
Sbjct: 191 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 250
Query: 218 -----YNDVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAV 266
N++R+ G L +M ++ +G+ + +K + +A ++ +I+ GA+
Sbjct: 251 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAI 304
Score = 61.7 bits (143), Expect = 1e-08
Identities = 36/82 (43%), Positives = 48/82 (58%), Gaps = 4/82 (4%)
Query: 304 NFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKGTLLALLISMVSYAMMVLFTGA--- 360
+F + IFFPSVTGI AG+N SGDLKD +IP GT+LA+L + Y V+ GA
Sbjct: 425 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 484
Query: 361 -AALRDASGNITDLVISNGTVT 381
LRD G+ + GT++
Sbjct: 485 GVVLRDKFGDAVKGNLVVGTLS 506
Score = 50.0 bits (114), Expect = 4e-05
Identities = 16/36 (44%), Positives = 24/36 (66%)
Query: 857 GTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIF 892
G +DVWW+ D G+ +LLP+++ Q W C +RIF
Sbjct: 850 GNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIF 885
Score = 46.0 bits (104), Expect = 7e-04
Identities = 19/63 (30%), Positives = 40/63 (63%)
Query: 974 LRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRGNHTSVLT 1033
++L E+++ S +++L+++++P P + YM +LE+++ L +L VRG + V+T
Sbjct: 1029 VKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVIT 1088
Query: 1034 FYS 1036
YS
Sbjct: 1089 IYS 1091
>AL117500-1|CAB55965.1| 1014|Homo sapiens hypothetical protein
protein.
Length = 1014
Score = 134 bits (323), Expect = 2e-30
Identities = 90/351 (25%), Positives = 148/351 (42%), Gaps = 11/351 (3%)
Query: 380 VTNYSAVSQCANSTLFPCKYGMHVDFEIMQLMSAW-GPFIYA-GCWXXXXXXXXXXXXXV 437
++N C + K+G V ++ +W P++ G +
Sbjct: 396 LSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGA 455
Query: 438 PRLIQALGVDRIYPGLIFFSKPYGRHGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFY 497
PRL+QA+ D I P L F +GE IA L+ +AP++S F+
Sbjct: 456 PRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTAAIAELGILIASLDLVAPILSMFF 514
Query: 498 LASYALINFCTFHAALVRPLGWRPTFKYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIF 557
L Y +N L+R WRP F+YY+ +S G +C+ +M + SW ++V + I
Sbjct: 515 LMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIA 574
Query: 558 FTLYLIVHYRNPDVNWGSSTQAQMYKTALSSAHNLARTGEHVKNYWPQLLV---LGGRAH 614
+Y + Y+ + WG + A + L H KN+ PQLLV L H
Sbjct: 575 GMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLH 634
Query: 615 AR-PPLVDLGSLITKAGSLMIIGDISKEKL--SYKVCSARARADNEWLQERKVRAFCSLV 671
+ P L+ S + L I+G + +Y A + ++ KV+ FC LV
Sbjct: 635 VKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLV 694
Query: 672 HGFNFEQGARALIQATGVGKLAPNVLLMGYKSDWTTASAEDLVAYFNVLHT 722
+G LIQ+ G+G + N ++MG+ + W +ED A+ + T
Sbjct: 695 VAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGW--RQSEDARAWKTFIGT 743
Score = 117 bits (281), Expect = 3e-25
Identities = 60/174 (34%), Positives = 104/174 (59%), Gaps = 8/174 (4%)
Query: 101 GVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVKG 160
GV +PCL NI+GV+LFLR++WVV AG+ + I+ + ++T +SMSAI TNG V
Sbjct: 54 GVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPA 113
Query: 161 GGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFCD-SMNHLLKSLDLQIIDNS-- 217
GG Y++ISR+LGPEFG +VG+ F AA+M +G + + +++ + D++
Sbjct: 114 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 173
Query: 218 -----YNDVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAV 266
N++R+ G L +M ++ +G+ + +K + +A ++ +I+ GA+
Sbjct: 174 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAI 227
Score = 61.7 bits (143), Expect = 1e-08
Identities = 36/82 (43%), Positives = 48/82 (58%), Gaps = 4/82 (4%)
Query: 304 NFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKGTLLALLISMVSYAMMVLFTGA--- 360
+F + IFFPSVTGI AG+N SGDLKD +IP GT+LA+L + Y V+ GA
Sbjct: 348 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 407
Query: 361 -AALRDASGNITDLVISNGTVT 381
LRD G+ + GT++
Sbjct: 408 GVVLRDKFGDAVKGNLVVGTLS 429
Score = 50.0 bits (114), Expect = 4e-05
Identities = 16/36 (44%), Positives = 24/36 (66%)
Query: 857 GTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIF 892
G +DVWW+ D G+ +LLP+++ Q W C +RIF
Sbjct: 773 GNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIF 808
Score = 46.0 bits (104), Expect = 7e-04
Identities = 19/63 (30%), Positives = 40/63 (63%)
Query: 974 LRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRGNHTSVLT 1033
++L E+++ S +++L+++++P P + YM +LE+++ L +L VRG + V+T
Sbjct: 952 VKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVIT 1011
Query: 1034 FYS 1036
YS
Sbjct: 1012 IYS 1014
>AF531260-1|AAQ10028.1| 1091|Homo sapiens K-Cl cotransporter
KCC3a-S2 isoform protein.
Length = 1091
Score = 134 bits (323), Expect = 2e-30
Identities = 90/351 (25%), Positives = 148/351 (42%), Gaps = 11/351 (3%)
Query: 380 VTNYSAVSQCANSTLFPCKYGMHVDFEIMQLMSAW-GPFIYA-GCWXXXXXXXXXXXXXV 437
++N C + K+G V ++ +W P++ G +
Sbjct: 473 LSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGA 532
Query: 438 PRLIQALGVDRIYPGLIFFSKPYGRHGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFY 497
PRL+QA+ D I P L F +GE IA L+ +AP++S F+
Sbjct: 533 PRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTAAIAELGILIASLDLVAPILSMFF 591
Query: 498 LASYALINFCTFHAALVRPLGWRPTFKYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIF 557
L Y +N L+R WRP F+YY+ +S G +C+ +M + SW ++V + I
Sbjct: 592 LMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIA 651
Query: 558 FTLYLIVHYRNPDVNWGSSTQAQMYKTALSSAHNLARTGEHVKNYWPQLLV---LGGRAH 614
+Y + Y+ + WG + A + L H KN+ PQLLV L H
Sbjct: 652 GMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLH 711
Query: 615 AR-PPLVDLGSLITKAGSLMIIGDISKEKL--SYKVCSARARADNEWLQERKVRAFCSLV 671
+ P L+ S + L I+G + +Y A + ++ KV+ FC LV
Sbjct: 712 VKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLV 771
Query: 672 HGFNFEQGARALIQATGVGKLAPNVLLMGYKSDWTTASAEDLVAYFNVLHT 722
+G LIQ+ G+G + N ++MG+ + W +ED A+ + T
Sbjct: 772 VAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGW--RQSEDARAWKTFIGT 820
Score = 117 bits (281), Expect = 3e-25
Identities = 60/174 (34%), Positives = 104/174 (59%), Gaps = 8/174 (4%)
Query: 101 GVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVKG 160
GV +PCL NI+GV+LFLR++WVV AG+ + I+ + ++T +SMSAI TNG V
Sbjct: 131 GVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPA 190
Query: 161 GGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFCD-SMNHLLKSLDLQIIDNS-- 217
GG Y++ISR+LGPEFG +VG+ F AA+M +G + + +++ + D++
Sbjct: 191 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 250
Query: 218 -----YNDVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAV 266
N++R+ G L +M ++ +G+ + +K + +A ++ +I+ GA+
Sbjct: 251 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAI 304
Score = 61.7 bits (143), Expect = 1e-08
Identities = 36/82 (43%), Positives = 48/82 (58%), Gaps = 4/82 (4%)
Query: 304 NFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKGTLLALLISMVSYAMMVLFTGA--- 360
+F + IFFPSVTGI AG+N SGDLKD +IP GT+LA+L + Y V+ GA
Sbjct: 425 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 484
Query: 361 -AALRDASGNITDLVISNGTVT 381
LRD G+ + GT++
Sbjct: 485 GVVLRDKFGDAVKGNLVVGTLS 506
Score = 50.0 bits (114), Expect = 4e-05
Identities = 16/36 (44%), Positives = 24/36 (66%)
Query: 857 GTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIF 892
G +DVWW+ D G+ +LLP+++ Q W C +RIF
Sbjct: 850 GNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIF 885
Score = 46.0 bits (104), Expect = 7e-04
Identities = 19/63 (30%), Positives = 40/63 (63%)
Query: 974 LRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRGNHTSVLT 1033
++L E+++ S +++L+++++P P + YM +LE+++ L +L VRG + V+T
Sbjct: 1029 VKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVIT 1088
Query: 1034 FYS 1036
YS
Sbjct: 1089 IYS 1091
>AF531259-1|AAQ10027.1| 1091|Homo sapiens K-Cl cotransporter
KCC3a-S1 isoform protein.
Length = 1091
Score = 134 bits (323), Expect = 2e-30
Identities = 90/351 (25%), Positives = 148/351 (42%), Gaps = 11/351 (3%)
Query: 380 VTNYSAVSQCANSTLFPCKYGMHVDFEIMQLMSAW-GPFIYA-GCWXXXXXXXXXXXXXV 437
++N C + K+G V ++ +W P++ G +
Sbjct: 473 LSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGA 532
Query: 438 PRLIQALGVDRIYPGLIFFSKPYGRHGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFY 497
PRL+QA+ D I P L F +GE IA L+ +AP++S F+
Sbjct: 533 PRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTAAIAELGILIASLDLVAPILSMFF 591
Query: 498 LASYALINFCTFHAALVRPLGWRPTFKYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIF 557
L Y +N L+R WRP F+YY+ +S G +C+ +M + SW ++V + I
Sbjct: 592 LMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIA 651
Query: 558 FTLYLIVHYRNPDVNWGSSTQAQMYKTALSSAHNLARTGEHVKNYWPQLLV---LGGRAH 614
+Y + Y+ + WG + A + L H KN+ PQLLV L H
Sbjct: 652 GMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLH 711
Query: 615 AR-PPLVDLGSLITKAGSLMIIGDISKEKL--SYKVCSARARADNEWLQERKVRAFCSLV 671
+ P L+ S + L I+G + +Y A + ++ KV+ FC LV
Sbjct: 712 VKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLV 771
Query: 672 HGFNFEQGARALIQATGVGKLAPNVLLMGYKSDWTTASAEDLVAYFNVLHT 722
+G LIQ+ G+G + N ++MG+ + W +ED A+ + T
Sbjct: 772 VAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGW--RQSEDARAWKTFIGT 820
Score = 117 bits (281), Expect = 3e-25
Identities = 60/174 (34%), Positives = 104/174 (59%), Gaps = 8/174 (4%)
Query: 101 GVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVKG 160
GV +PCL NI+GV+LFLR++WVV AG+ + I+ + ++T +SMSAI TNG V
Sbjct: 131 GVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPA 190
Query: 161 GGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFCD-SMNHLLKSLDLQIIDNS-- 217
GG Y++ISR+LGPEFG +VG+ F AA+M +G + + +++ + D++
Sbjct: 191 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 250
Query: 218 -----YNDVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAV 266
N++R+ G L +M ++ +G+ + +K + +A ++ +I+ GA+
Sbjct: 251 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAI 304
Score = 61.7 bits (143), Expect = 1e-08
Identities = 36/82 (43%), Positives = 48/82 (58%), Gaps = 4/82 (4%)
Query: 304 NFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKGTLLALLISMVSYAMMVLFTGA--- 360
+F + IFFPSVTGI AG+N SGDLKD +IP GT+LA+L + Y V+ GA
Sbjct: 425 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 484
Query: 361 -AALRDASGNITDLVISNGTVT 381
LRD G+ + GT++
Sbjct: 485 GVVLRDKFGDAVKGNLVVGTLS 506
Score = 50.0 bits (114), Expect = 4e-05
Identities = 16/36 (44%), Positives = 24/36 (66%)
Query: 857 GTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIF 892
G +DVWW+ D G+ +LLP+++ Q W C +RIF
Sbjct: 850 GNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIF 885
Score = 46.0 bits (104), Expect = 7e-04
Identities = 19/63 (30%), Positives = 40/63 (63%)
Query: 974 LRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRGNHTSVLT 1033
++L E+++ S +++L+++++P P + YM +LE+++ L +L VRG + V+T
Sbjct: 1029 VKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVIT 1088
Query: 1034 FYS 1036
YS
Sbjct: 1089 IYS 1091
>AF531258-1|AAQ10026.1| 1135|Homo sapiens K-Cl cotransporter
KCC3a-X2M isoform protein.
Length = 1135
Score = 134 bits (323), Expect = 2e-30
Identities = 90/351 (25%), Positives = 148/351 (42%), Gaps = 11/351 (3%)
Query: 380 VTNYSAVSQCANSTLFPCKYGMHVDFEIMQLMSAW-GPFIYA-GCWXXXXXXXXXXXXXV 437
++N C + K+G V ++ +W P++ G +
Sbjct: 517 LSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGA 576
Query: 438 PRLIQALGVDRIYPGLIFFSKPYGRHGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFY 497
PRL+QA+ D I P L F +GE IA L+ +AP++S F+
Sbjct: 577 PRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTAAIAELGILIASLDLVAPILSMFF 635
Query: 498 LASYALINFCTFHAALVRPLGWRPTFKYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIF 557
L Y +N L+R WRP F+YY+ +S G +C+ +M + SW ++V + I
Sbjct: 636 LMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIA 695
Query: 558 FTLYLIVHYRNPDVNWGSSTQAQMYKTALSSAHNLARTGEHVKNYWPQLLV---LGGRAH 614
+Y + Y+ + WG + A + L H KN+ PQLLV L H
Sbjct: 696 GMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLH 755
Query: 615 AR-PPLVDLGSLITKAGSLMIIGDISKEKL--SYKVCSARARADNEWLQERKVRAFCSLV 671
+ P L+ S + L I+G + +Y A + ++ KV+ FC LV
Sbjct: 756 VKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLV 815
Query: 672 HGFNFEQGARALIQATGVGKLAPNVLLMGYKSDWTTASAEDLVAYFNVLHT 722
+G LIQ+ G+G + N ++MG+ + W +ED A+ + T
Sbjct: 816 VAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGW--RQSEDARAWKTFIGT 864
Score = 117 bits (281), Expect = 3e-25
Identities = 60/174 (34%), Positives = 104/174 (59%), Gaps = 8/174 (4%)
Query: 101 GVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVKG 160
GV +PCL NI+GV+LFLR++WVV AG+ + I+ + ++T +SMSAI TNG V
Sbjct: 175 GVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPA 234
Query: 161 GGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFCD-SMNHLLKSLDLQIIDNS-- 217
GG Y++ISR+LGPEFG +VG+ F AA+M +G + + +++ + D++
Sbjct: 235 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 294
Query: 218 -----YNDVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAV 266
N++R+ G L +M ++ +G+ + +K + +A ++ +I+ GA+
Sbjct: 295 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAI 348
Score = 61.7 bits (143), Expect = 1e-08
Identities = 36/82 (43%), Positives = 48/82 (58%), Gaps = 4/82 (4%)
Query: 304 NFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKGTLLALLISMVSYAMMVLFTGA--- 360
+F + IFFPSVTGI AG+N SGDLKD +IP GT+LA+L + Y V+ GA
Sbjct: 469 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 528
Query: 361 -AALRDASGNITDLVISNGTVT 381
LRD G+ + GT++
Sbjct: 529 GVVLRDKFGDAVKGNLVVGTLS 550
Score = 50.0 bits (114), Expect = 4e-05
Identities = 16/36 (44%), Positives = 24/36 (66%)
Query: 857 GTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIF 892
G +DVWW+ D G+ +LLP+++ Q W C +RIF
Sbjct: 894 GNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIF 929
Score = 46.0 bits (104), Expect = 7e-04
Identities = 19/63 (30%), Positives = 40/63 (63%)
Query: 974 LRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRGNHTSVLT 1033
++L E+++ S +++L+++++P P + YM +LE+++ L +L VRG + V+T
Sbjct: 1073 VKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVIT 1132
Query: 1034 FYS 1036
YS
Sbjct: 1133 IYS 1135
>AF477977-1|AAL85335.1| 1011|Homo sapiens K-Cl cotransporter KCC3
variant isoform protein.
Length = 1011
Score = 134 bits (323), Expect = 2e-30
Identities = 90/351 (25%), Positives = 148/351 (42%), Gaps = 11/351 (3%)
Query: 380 VTNYSAVSQCANSTLFPCKYGMHVDFEIMQLMSAW-GPFIYA-GCWXXXXXXXXXXXXXV 437
++N C + K+G V ++ +W P++ G +
Sbjct: 393 LSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGA 452
Query: 438 PRLIQALGVDRIYPGLIFFSKPYGRHGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFY 497
PRL+QA+ D I P L F +GE IA L+ +AP++S F+
Sbjct: 453 PRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTAAIAELGILIASLDLVAPILSMFF 511
Query: 498 LASYALINFCTFHAALVRPLGWRPTFKYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIF 557
L Y +N L+R WRP F+YY+ +S G +C+ +M + SW ++V + I
Sbjct: 512 LMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIA 571
Query: 558 FTLYLIVHYRNPDVNWGSSTQAQMYKTALSSAHNLARTGEHVKNYWPQLLV---LGGRAH 614
+Y + Y+ + WG + A + L H KN+ PQLLV L H
Sbjct: 572 GMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLH 631
Query: 615 AR-PPLVDLGSLITKAGSLMIIGDISKEKL--SYKVCSARARADNEWLQERKVRAFCSLV 671
+ P L+ S + L I+G + +Y A + ++ KV+ FC LV
Sbjct: 632 VKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLV 691
Query: 672 HGFNFEQGARALIQATGVGKLAPNVLLMGYKSDWTTASAEDLVAYFNVLHT 722
+G LIQ+ G+G + N ++MG+ + W +ED A+ + T
Sbjct: 692 VAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGW--RQSEDARAWKTFIGT 740
Score = 117 bits (281), Expect = 3e-25
Identities = 60/174 (34%), Positives = 104/174 (59%), Gaps = 8/174 (4%)
Query: 101 GVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVKG 160
GV +PCL NI+GV+LFLR++WVV AG+ + I+ + ++T +SMSAI TNG V
Sbjct: 51 GVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPA 110
Query: 161 GGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFCD-SMNHLLKSLDLQIIDNS-- 217
GG Y++ISR+LGPEFG +VG+ F AA+M +G + + +++ + D++
Sbjct: 111 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 170
Query: 218 -----YNDVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAV 266
N++R+ G L +M ++ +G+ + +K + +A ++ +I+ GA+
Sbjct: 171 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAI 224
Score = 61.7 bits (143), Expect = 1e-08
Identities = 36/82 (43%), Positives = 48/82 (58%), Gaps = 4/82 (4%)
Query: 304 NFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKGTLLALLISMVSYAMMVLFTGA--- 360
+F + IFFPSVTGI AG+N SGDLKD +IP GT+LA+L + Y V+ GA
Sbjct: 345 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 404
Query: 361 -AALRDASGNITDLVISNGTVT 381
LRD G+ + GT++
Sbjct: 405 GVVLRDKFGDAVKGNLVVGTLS 426
Score = 50.0 bits (114), Expect = 4e-05
Identities = 16/36 (44%), Positives = 24/36 (66%)
Query: 857 GTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIF 892
G +DVWW+ D G+ +LLP+++ Q W C +RIF
Sbjct: 770 GNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIF 805
Score = 46.0 bits (104), Expect = 7e-04
Identities = 19/63 (30%), Positives = 40/63 (63%)
Query: 974 LRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRGNHTSVLT 1033
++L E+++ S +++L+++++P P + YM +LE+++ L +L VRG + V+T
Sbjct: 949 VKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVIT 1008
Query: 1034 FYS 1036
YS
Sbjct: 1009 IYS 1011
>AF314956-2|AAM96216.1| 1099|Homo sapiens potassium-chloride
transporter-3b protein.
Length = 1099
Score = 134 bits (323), Expect = 2e-30
Identities = 90/351 (25%), Positives = 148/351 (42%), Gaps = 11/351 (3%)
Query: 380 VTNYSAVSQCANSTLFPCKYGMHVDFEIMQLMSAW-GPFIYA-GCWXXXXXXXXXXXXXV 437
++N C + K+G V ++ +W P++ G +
Sbjct: 481 LSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGA 540
Query: 438 PRLIQALGVDRIYPGLIFFSKPYGRHGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFY 497
PRL+QA+ D I P L F +GE IA L+ +AP++S F+
Sbjct: 541 PRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTAAIAELGILIASLDLVAPILSMFF 599
Query: 498 LASYALINFCTFHAALVRPLGWRPTFKYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIF 557
L Y +N L+R WRP F+YY+ +S G +C+ +M + SW ++V + I
Sbjct: 600 LMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIA 659
Query: 558 FTLYLIVHYRNPDVNWGSSTQAQMYKTALSSAHNLARTGEHVKNYWPQLLV---LGGRAH 614
+Y + Y+ + WG + A + L H KN+ PQLLV L H
Sbjct: 660 GMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLH 719
Query: 615 AR-PPLVDLGSLITKAGSLMIIGDISKEKL--SYKVCSARARADNEWLQERKVRAFCSLV 671
+ P L+ S + L I+G + +Y A + ++ KV+ FC LV
Sbjct: 720 VKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLV 779
Query: 672 HGFNFEQGARALIQATGVGKLAPNVLLMGYKSDWTTASAEDLVAYFNVLHT 722
+G LIQ+ G+G + N ++MG+ + W +ED A+ + T
Sbjct: 780 VAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGW--RQSEDARAWKTFIGT 828
Score = 117 bits (281), Expect = 3e-25
Identities = 60/174 (34%), Positives = 104/174 (59%), Gaps = 8/174 (4%)
Query: 101 GVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVKG 160
GV +PCL NI+GV+LFLR++WVV AG+ + I+ + ++T +SMSAI TNG V
Sbjct: 139 GVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPA 198
Query: 161 GGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFCD-SMNHLLKSLDLQIIDNS-- 217
GG Y++ISR+LGPEFG +VG+ F AA+M +G + + +++ + D++
Sbjct: 199 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 258
Query: 218 -----YNDVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAV 266
N++R+ G L +M ++ +G+ + +K + +A ++ +I+ GA+
Sbjct: 259 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAI 312
Score = 61.7 bits (143), Expect = 1e-08
Identities = 36/82 (43%), Positives = 48/82 (58%), Gaps = 4/82 (4%)
Query: 304 NFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKGTLLALLISMVSYAMMVLFTGA--- 360
+F + IFFPSVTGI AG+N SGDLKD +IP GT+LA+L + Y V+ GA
Sbjct: 433 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 492
Query: 361 -AALRDASGNITDLVISNGTVT 381
LRD G+ + GT++
Sbjct: 493 GVVLRDKFGDAVKGNLVVGTLS 514
Score = 50.0 bits (114), Expect = 4e-05
Identities = 16/36 (44%), Positives = 24/36 (66%)
Query: 857 GTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIF 892
G +DVWW+ D G+ +LLP+++ Q W C +RIF
Sbjct: 858 GNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIF 893
Score = 46.0 bits (104), Expect = 7e-04
Identities = 19/63 (30%), Positives = 40/63 (63%)
Query: 974 LRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRGNHTSVLT 1033
++L E+++ S +++L+++++P P + YM +LE+++ L +L VRG + V+T
Sbjct: 1037 VKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVIT 1096
Query: 1034 FYS 1036
YS
Sbjct: 1097 IYS 1099
>AF314956-1|AAM96215.1| 1150|Homo sapiens potassium-chloride
transporter-3a protein.
Length = 1150
Score = 134 bits (323), Expect = 2e-30
Identities = 90/351 (25%), Positives = 148/351 (42%), Gaps = 11/351 (3%)
Query: 380 VTNYSAVSQCANSTLFPCKYGMHVDFEIMQLMSAW-GPFIYA-GCWXXXXXXXXXXXXXV 437
++N C + K+G V ++ +W P++ G +
Sbjct: 532 LSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGA 591
Query: 438 PRLIQALGVDRIYPGLIFFSKPYGRHGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFY 497
PRL+QA+ D I P L F +GE IA L+ +AP++S F+
Sbjct: 592 PRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTAAIAELGILIASLDLVAPILSMFF 650
Query: 498 LASYALINFCTFHAALVRPLGWRPTFKYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIF 557
L Y +N L+R WRP F+YY+ +S G +C+ +M + SW ++V + I
Sbjct: 651 LMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIA 710
Query: 558 FTLYLIVHYRNPDVNWGSSTQAQMYKTALSSAHNLARTGEHVKNYWPQLLV---LGGRAH 614
+Y + Y+ + WG + A + L H KN+ PQLLV L H
Sbjct: 711 GMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLH 770
Query: 615 AR-PPLVDLGSLITKAGSLMIIGDISKEKL--SYKVCSARARADNEWLQERKVRAFCSLV 671
+ P L+ S + L I+G + +Y A + ++ KV+ FC LV
Sbjct: 771 VKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLV 830
Query: 672 HGFNFEQGARALIQATGVGKLAPNVLLMGYKSDWTTASAEDLVAYFNVLHT 722
+G LIQ+ G+G + N ++MG+ + W +ED A+ + T
Sbjct: 831 VAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGW--RQSEDARAWKTFIGT 879
Score = 117 bits (281), Expect = 3e-25
Identities = 60/174 (34%), Positives = 104/174 (59%), Gaps = 8/174 (4%)
Query: 101 GVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVKG 160
GV +PCL NI+GV+LFLR++WVV AG+ + I+ + ++T +SMSAI TNG V
Sbjct: 190 GVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPA 249
Query: 161 GGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFCD-SMNHLLKSLDLQIIDNS-- 217
GG Y++ISR+LGPEFG +VG+ F AA+M +G + + +++ + D++
Sbjct: 250 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 309
Query: 218 -----YNDVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAV 266
N++R+ G L +M ++ +G+ + +K + +A ++ +I+ GA+
Sbjct: 310 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAI 363
Score = 61.7 bits (143), Expect = 1e-08
Identities = 36/82 (43%), Positives = 48/82 (58%), Gaps = 4/82 (4%)
Query: 304 NFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKGTLLALLISMVSYAMMVLFTGA--- 360
+F + IFFPSVTGI AG+N SGDLKD +IP GT+LA+L + Y V+ GA
Sbjct: 484 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 543
Query: 361 -AALRDASGNITDLVISNGTVT 381
LRD G+ + GT++
Sbjct: 544 GVVLRDKFGDAVKGNLVVGTLS 565
Score = 50.0 bits (114), Expect = 4e-05
Identities = 16/36 (44%), Positives = 24/36 (66%)
Query: 857 GTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIF 892
G +DVWW+ D G+ +LLP+++ Q W C +RIF
Sbjct: 909 GNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIF 944
Score = 46.0 bits (104), Expect = 7e-04
Identities = 19/63 (30%), Positives = 40/63 (63%)
Query: 974 LRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRGNHTSVLT 1033
++L E+++ S +++L+++++P P + YM +LE+++ L +L VRG + V+T
Sbjct: 1088 VKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVIT 1147
Query: 1034 FYS 1036
YS
Sbjct: 1148 IYS 1150
>AF116242-1|AAF24986.1| 1150|Homo sapiens K-Cl cotransporter KCC3
protein.
Length = 1150
Score = 134 bits (323), Expect = 2e-30
Identities = 90/351 (25%), Positives = 148/351 (42%), Gaps = 11/351 (3%)
Query: 380 VTNYSAVSQCANSTLFPCKYGMHVDFEIMQLMSAW-GPFIYA-GCWXXXXXXXXXXXXXV 437
++N C + K+G V ++ +W P++ G +
Sbjct: 532 LSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGA 591
Query: 438 PRLIQALGVDRIYPGLIFFSKPYGRHGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFY 497
PRL+QA+ D I P L F +GE IA L+ +AP++S F+
Sbjct: 592 PRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTAAIAELGILIASLDLVAPILSMFF 650
Query: 498 LASYALINFCTFHAALVRPLGWRPTFKYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIF 557
L Y +N L+R WRP F+YY+ +S G +C+ +M + SW ++V + I
Sbjct: 651 LMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIA 710
Query: 558 FTLYLIVHYRNPDVNWGSSTQAQMYKTALSSAHNLARTGEHVKNYWPQLLV---LGGRAH 614
+Y + Y+ + WG + A + L H KN+ PQLLV L H
Sbjct: 711 GMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLH 770
Query: 615 AR-PPLVDLGSLITKAGSLMIIGDISKEKL--SYKVCSARARADNEWLQERKVRAFCSLV 671
+ P L+ S + L I+G + +Y A + ++ KV+ FC LV
Sbjct: 771 VKHPRLLTFASQLKAGKGLTIVGSVIVGNFLHNYGEALAAEQTIKHLMEAEKVKGFCQLV 830
Query: 672 HGFNFEQGARALIQATGVGKLAPNVLLMGYKSDWTTASAEDLVAYFNVLHT 722
+G LIQ+ G+G + N ++MG+ + W +ED A+ + T
Sbjct: 831 VAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGW--RQSEDARAWKTFIGT 879
Score = 117 bits (281), Expect = 3e-25
Identities = 60/174 (34%), Positives = 104/174 (59%), Gaps = 8/174 (4%)
Query: 101 GVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVKG 160
GV +PCL NI+GV+LFLR++WVV AG+ + I+ + ++T +SMSAI TNG V
Sbjct: 190 GVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPA 249
Query: 161 GGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFCD-SMNHLLKSLDLQIIDNS-- 217
GG Y++ISR+LGPEFG +VG+ F AA+M +G + + +++ + D++
Sbjct: 250 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 309
Query: 218 -----YNDVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAV 266
N++R+ G L +M ++ +G+ + +K + +A ++ +I+ GA+
Sbjct: 310 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAI 363
Score = 61.7 bits (143), Expect = 1e-08
Identities = 36/82 (43%), Positives = 48/82 (58%), Gaps = 4/82 (4%)
Query: 304 NFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKGTLLALLISMVSYAMMVLFTGA--- 360
+F + IFFPSVTGI AG+N SGDLKD +IP GT+LA+L + Y V+ GA
Sbjct: 484 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 543
Query: 361 -AALRDASGNITDLVISNGTVT 381
LRD G+ + GT++
Sbjct: 544 GVVLRDKFGDAVKGNLVVGTLS 565
Score = 50.0 bits (114), Expect = 4e-05
Identities = 16/36 (44%), Positives = 24/36 (66%)
Query: 857 GTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIF 892
G +DVWW+ D G+ +LLP+++ Q W C +RIF
Sbjct: 909 GNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIF 944
Score = 46.0 bits (104), Expect = 7e-04
Identities = 19/63 (30%), Positives = 40/63 (63%)
Query: 974 LRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRGNHTSVLT 1033
++L E+++ S +++L+++++P P + YM +LE+++ L +L VRG + V+T
Sbjct: 1088 VKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVIT 1147
Query: 1034 FYS 1036
YS
Sbjct: 1148 IYS 1150
>AF108831-1|AAD25337.1| 1099|Homo sapiens K:Cl cotransporter 3
protein.
Length = 1099
Score = 134 bits (323), Expect = 2e-30
Identities = 90/351 (25%), Positives = 148/351 (42%), Gaps = 11/351 (3%)
Query: 380 VTNYSAVSQCANSTLFPCKYGMHVDFEIMQLMSAW-GPFIYA-GCWXXXXXXXXXXXXXV 437
++N C + K+G V ++ +W P++ G +
Sbjct: 481 LSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGA 540
Query: 438 PRLIQALGVDRIYPGLIFFSKPYGRHGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFY 497
PRL+QA+ D I P L F +GE IA L+ +AP++S F+
Sbjct: 541 PRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTAAIAELGILIASLDLVAPILSMFF 599
Query: 498 LASYALINFCTFHAALVRPLGWRPTFKYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIF 557
L Y +N L+R WRP F+YY+ +S G +C+ +M + SW ++V + I
Sbjct: 600 LMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIA 659
Query: 558 FTLYLIVHYRNPDVNWGSSTQAQMYKTALSSAHNLARTGEHVKNYWPQLLV---LGGRAH 614
+Y + Y+ + WG + A + L H KN+ PQLLV L H
Sbjct: 660 GMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLH 719
Query: 615 AR-PPLVDLGSLITKAGSLMIIGDISKEKL--SYKVCSARARADNEWLQERKVRAFCSLV 671
+ P L+ S + L I+G + +Y A + ++ KV+ FC LV
Sbjct: 720 VKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLV 779
Query: 672 HGFNFEQGARALIQATGVGKLAPNVLLMGYKSDWTTASAEDLVAYFNVLHT 722
+G LIQ+ G+G + N ++MG+ + W +ED A+ + T
Sbjct: 780 VAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGW--RQSEDARAWKTFIGT 828
Score = 117 bits (281), Expect = 3e-25
Identities = 60/174 (34%), Positives = 104/174 (59%), Gaps = 8/174 (4%)
Query: 101 GVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVKG 160
GV +PCL NI+GV+LFLR++WVV AG+ + I+ + ++T +SMSAI TNG V
Sbjct: 139 GVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPA 198
Query: 161 GGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFCD-SMNHLLKSLDLQIIDNS-- 217
GG Y++ISR+LGPEFG +VG+ F AA+M +G + + +++ + D++
Sbjct: 199 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 258
Query: 218 -----YNDVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAV 266
N++R+ G L +M ++ +G+ + +K + +A ++ +I+ GA+
Sbjct: 259 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAI 312
Score = 61.7 bits (143), Expect = 1e-08
Identities = 36/82 (43%), Positives = 48/82 (58%), Gaps = 4/82 (4%)
Query: 304 NFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKGTLLALLISMVSYAMMVLFTGA--- 360
+F + IFFPSVTGI AG+N SGDLKD +IP GT+LA+L + Y V+ GA
Sbjct: 433 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 492
Query: 361 -AALRDASGNITDLVISNGTVT 381
LRD G+ + GT++
Sbjct: 493 GVVLRDKFGDAVKGNLVVGTLS 514
Score = 50.0 bits (114), Expect = 4e-05
Identities = 16/36 (44%), Positives = 24/36 (66%)
Query: 857 GTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIF 892
G +DVWW+ D G+ +LLP+++ Q W C +RIF
Sbjct: 858 GNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIF 893
Score = 46.0 bits (104), Expect = 7e-04
Identities = 19/63 (30%), Positives = 40/63 (63%)
Query: 974 LRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRGNHTSVLT 1033
++L E+++ S +++L+++++P P + YM +LE+++ L +L VRG + V+T
Sbjct: 1037 VKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVIT 1096
Query: 1034 FYS 1036
YS
Sbjct: 1097 IYS 1099
>AF105366-1|AAD39742.1| 1150|Homo sapiens K-Cl cotransporter KCC3a
protein.
Length = 1150
Score = 134 bits (323), Expect = 2e-30
Identities = 90/351 (25%), Positives = 148/351 (42%), Gaps = 11/351 (3%)
Query: 380 VTNYSAVSQCANSTLFPCKYGMHVDFEIMQLMSAW-GPFIYA-GCWXXXXXXXXXXXXXV 437
++N C + K+G V ++ +W P++ G +
Sbjct: 532 LSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGA 591
Query: 438 PRLIQALGVDRIYPGLIFFSKPYGRHGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFY 497
PRL+QA+ D I P L F +GE IA L+ +AP++S F+
Sbjct: 592 PRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTAAIAELGILIASLDLVAPILSMFF 650
Query: 498 LASYALINFCTFHAALVRPLGWRPTFKYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIF 557
L Y +N L+R WRP F+YY+ +S G +C+ +M + SW ++V + I
Sbjct: 651 LMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIA 710
Query: 558 FTLYLIVHYRNPDVNWGSSTQAQMYKTALSSAHNLARTGEHVKNYWPQLLV---LGGRAH 614
+Y + Y+ + WG + A + L H KN+ PQLLV L H
Sbjct: 711 GMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLH 770
Query: 615 AR-PPLVDLGSLITKAGSLMIIGDISKEKL--SYKVCSARARADNEWLQERKVRAFCSLV 671
+ P L+ S + L I+G + +Y A + ++ KV+ FC LV
Sbjct: 771 VKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLV 830
Query: 672 HGFNFEQGARALIQATGVGKLAPNVLLMGYKSDWTTASAEDLVAYFNVLHT 722
+G LIQ+ G+G + N ++MG+ + W +ED A+ + T
Sbjct: 831 VAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGW--RQSEDARAWKTFIGT 879
Score = 117 bits (281), Expect = 3e-25
Identities = 60/174 (34%), Positives = 104/174 (59%), Gaps = 8/174 (4%)
Query: 101 GVLIPCLLNIWGVMLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVKG 160
GV +PCL NI+GV+LFLR++WVV AG+ + I+ + ++T +SMSAI TNG V
Sbjct: 190 GVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPA 249
Query: 161 GGIYYIISRSLGPEFGASVGIIFAFANAVAASMNTIGFCD-SMNHLLKSLDLQIIDNS-- 217
GG Y++ISR+LGPEFG +VG+ F AA+M +G + + +++ + D++
Sbjct: 250 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 309
Query: 218 -----YNDVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAV 266
N++R+ G L +M ++ +G+ + +K + +A ++ +I+ GA+
Sbjct: 310 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAI 363
Score = 61.7 bits (143), Expect = 1e-08
Identities = 36/82 (43%), Positives = 48/82 (58%), Gaps = 4/82 (4%)
Query: 304 NFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKGTLLALLISMVSYAMMVLFTGA--- 360
+F + IFFPSVTGI AG+N SGDLKD +IP GT+LA+L + Y V+ GA
Sbjct: 484 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 543
Query: 361 -AALRDASGNITDLVISNGTVT 381
LRD G+ + GT++
Sbjct: 544 GVVLRDKFGDAVKGNLVVGTLS 565
Score = 50.0 bits (114), Expect = 4e-05
Identities = 16/36 (44%), Positives = 24/36 (66%)
Query: 857 GTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIF 892
G +DVWW+ D G+ +LLP+++ Q W C +RIF
Sbjct: 909 GNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIF 944
Score = 46.0 bits (104), Expect = 7e-04
Identities = 19/63 (30%), Positives = 40/63 (63%)
Query: 974 LRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRGNHTSVLT 1033
++L E+++ S +++L+++++P P + YM +LE+++ L +L VRG + V+T
Sbjct: 1088 VKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVIT 1147
Query: 1034 FYS 1036
YS
Sbjct: 1148 IYS 1150
>BC098390-1|AAH98390.1| 1083|Homo sapiens solute carrier family 12
(potassium/chloride transporters), member 7 protein.
Length = 1083
Score = 132 bits (319), Expect = 6e-30
Identities = 86/326 (26%), Positives = 141/326 (43%), Gaps = 11/326 (3%)
Query: 389 CANSTLFPCKYGMHVDFEIMQLMSAW-GPFIYA-GCWXXXXXXXXXXXXXVPRLIQALGV 446
C + K+G + ++ M AW P++ G + PRL+QA+
Sbjct: 476 CIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAR 535
Query: 447 DRIYPGLIFFSKPYGR-HGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFYLASYALIN 505
D I P L F +G+ +GE IA L+++AP++S F+L Y +N
Sbjct: 536 DGIVPFLQVFG--HGKANGEPTWALLLTVLICETGILIASLDSVAPILSMFFLMCYLFVN 593
Query: 506 FCTFHAALVRPLGWRPTFKYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIFFTLYLIVH 565
L+R WRP FK+Y+ +S G +C+ +M + SW +L + I +Y +
Sbjct: 594 LACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIE 653
Query: 566 YRNPDVNWGSSTQAQMYKTALSSAHNLARTGEHVKNYWPQLLVL----GGRAHARPPLVD 621
YR + WG + A + + H KN+ PQ+LV+ +A P L+
Sbjct: 654 YRGAEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPRLLS 713
Query: 622 LGSLITKAGSLMIIGDISKEKLSYKVCSARARADN--EWLQERKVRAFCSLVHGFNFEQG 679
S + L I+G + + K A+ +N + K + FC LV + G
Sbjct: 714 FTSQLKAGKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKTKGFCQLVVSSSLRDG 773
Query: 680 ARALIQATGVGKLAPNVLLMGYKSDW 705
LIQ+ G+G L N +LM + + W
Sbjct: 774 MSHLIQSAGLGGLKHNTVLMAWPASW 799
Score = 116 bits (278), Expect = 6e-25
Identities = 68/210 (32%), Positives = 114/210 (54%), Gaps = 16/210 (7%)
Query: 65 LTREALPRMENYRNSKRALKRPSLGELHGDHLITEEGVLIPCLLNIWGVMLFLRISWVVS 124
L++ + E+ + +R K P +G T GV +PCL NI GV+LFLR++W+V
Sbjct: 95 LSQGVVEHEEDEESRRREAKAPRMG--------TFIGVYLPCLQNILGVILFLRLTWIVG 146
Query: 125 QAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVKGGGIYYIISRSLGPEFGASVGIIFA 184
AG+ S +I+A+ ++T +SMSAI TNG V GG YY+ISRSLGPEFG +VG+ F
Sbjct: 147 VAGVLESFLIVAMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFY 206
Query: 185 FANAVAASMNTIGFCD-SMNHLLKSLDLQIIDNS-------YNDVRIIGAIALFVMCVIC 236
A +M +G + + ++ + + + +++R+ G L +M ++
Sbjct: 207 LGTTFAGAMYILGTIEIFLTYISPGAAIFQAEAAGGEAAAMLHNMRVYGTCTLVLMALVV 266
Query: 237 AVGMDWESKAQNFLIAIIVGAIVDFVVGAV 266
VG+ + +K +A +V +I+ G +
Sbjct: 267 FVGVKYVNKLALVFLACVVLSILAIYAGVI 296
Score = 59.3 bits (137), Expect = 7e-08
Identities = 31/69 (44%), Positives = 42/69 (60%), Gaps = 4/69 (5%)
Query: 304 NFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKGTLLALLISMVSYAMMVLFTGA--- 360
+F + I+FPSVTGI AG+N SGDLKD +IP GT+LA++ + Y ++ GA
Sbjct: 419 SFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIE 478
Query: 361 -AALRDASG 368
LRD G
Sbjct: 479 GVVLRDKFG 487
Score = 50.0 bits (114), Expect = 4e-05
Identities = 19/46 (41%), Positives = 29/46 (63%), Gaps = 3/46 (6%)
Query: 850 FKRKQE---SGTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIF 892
F + QE G +DVWW+ D G+ +LLP+++ Q W C++RIF
Sbjct: 834 FPQNQERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIF 879
Score = 45.6 bits (103), Expect = 0.001
Identities = 21/63 (33%), Positives = 39/63 (61%)
Query: 974 LRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRGNHTSVLT 1033
++L ++L S+D++L+++++P P K YM +LE+++ L +L VRG V+T
Sbjct: 1021 VKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGGGREVIT 1080
Query: 1034 FYS 1036
YS
Sbjct: 1081 IYS 1083
>AK024497-1|BAB15787.1| 721|Homo sapiens FLJ00105 protein protein.
Length = 721
Score = 132 bits (319), Expect = 6e-30
Identities = 86/326 (26%), Positives = 141/326 (43%), Gaps = 11/326 (3%)
Query: 389 CANSTLFPCKYGMHVDFEIMQLMSAW-GPFIYA-GCWXXXXXXXXXXXXXVPRLIQALGV 446
C + K+G + ++ M AW P++ G + PRL+QA+
Sbjct: 114 CIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAR 173
Query: 447 DRIYPGLIFFSKPYGR-HGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFYLASYALIN 505
D I P L F +G+ +GE IA L+++AP++S F+L Y +N
Sbjct: 174 DGIVPFLQVFG--HGKANGEPTWALLLTVLICETGILIASLDSVAPILSMFFLMCYLFVN 231
Query: 506 FCTFHAALVRPLGWRPTFKYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIFFTLYLIVH 565
L+R WRP FK+Y+ +S G +C+ +M + SW +L + I +Y +
Sbjct: 232 LACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIE 291
Query: 566 YRNPDVNWGSSTQAQMYKTALSSAHNLARTGEHVKNYWPQLLVL----GGRAHARPPLVD 621
YR + WG + A + + H KN+ PQ+LV+ +A P L+
Sbjct: 292 YRGAEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPRLLS 351
Query: 622 LGSLITKAGSLMIIGDISKEKLSYKVCSARARADN--EWLQERKVRAFCSLVHGFNFEQG 679
S + L I+G + + K A+ +N + K + FC LV + G
Sbjct: 352 FTSQLKAGKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKTKGFCQLVVSSSLRDG 411
Query: 680 ARALIQATGVGKLAPNVLLMGYKSDW 705
LIQ+ G+G L N +LM + + W
Sbjct: 412 MSHLIQSAGLGGLKHNTVLMAWPASW 437
Score = 59.3 bits (137), Expect = 7e-08
Identities = 31/69 (44%), Positives = 42/69 (60%), Gaps = 4/69 (5%)
Query: 304 NFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKGTLLALLISMVSYAMMVLFTGA--- 360
+F + I+FPSVTGI AG+N SGDLKD +IP GT+LA++ + Y ++ GA
Sbjct: 57 SFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIE 116
Query: 361 -AALRDASG 368
LRD G
Sbjct: 117 GVVLRDKFG 125
Score = 50.0 bits (114), Expect = 4e-05
Identities = 19/46 (41%), Positives = 29/46 (63%), Gaps = 3/46 (6%)
Query: 850 FKRKQE---SGTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIF 892
F + QE G +DVWW+ D G+ +LLP+++ Q W C++RIF
Sbjct: 472 FPQNQERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIF 517
Score = 45.6 bits (103), Expect = 0.001
Identities = 21/63 (33%), Positives = 39/63 (61%)
Query: 974 LRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRGNHTSVLT 1033
++L ++L S+D++L+++++P P K YM +LE+++ L +L VRG V+T
Sbjct: 659 VKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGGGREVIT 718
Query: 1034 FYS 1036
YS
Sbjct: 719 IYS 721
>AK024493-1|BAB15783.1| 780|Homo sapiens FLJ00098 protein protein.
Length = 780
Score = 132 bits (319), Expect = 6e-30
Identities = 86/326 (26%), Positives = 141/326 (43%), Gaps = 11/326 (3%)
Query: 389 CANSTLFPCKYGMHVDFEIMQLMSAW-GPFIYA-GCWXXXXXXXXXXXXXVPRLIQALGV 446
C + K+G + ++ M AW P++ G + PRL+QA+
Sbjct: 173 CIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAR 232
Query: 447 DRIYPGLIFFSKPYGR-HGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFYLASYALIN 505
D I P L F +G+ +GE IA L+++AP++S F+L Y +N
Sbjct: 233 DGIVPFLQVFG--HGKANGEPTWALLLTVLICETGILIASLDSVAPILSMFFLMCYLFVN 290
Query: 506 FCTFHAALVRPLGWRPTFKYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIFFTLYLIVH 565
L+R WRP FK+Y+ +S G +C+ +M + SW +L + I +Y +
Sbjct: 291 LACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIE 350
Query: 566 YRNPDVNWGSSTQAQMYKTALSSAHNLARTGEHVKNYWPQLLVL----GGRAHARPPLVD 621
YR + WG + A + + H KN+ PQ+LV+ +A P L+
Sbjct: 351 YRGAEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPRLLS 410
Query: 622 LGSLITKAGSLMIIGDISKEKLSYKVCSARARADN--EWLQERKVRAFCSLVHGFNFEQG 679
S + L I+G + + K A+ +N + K + FC LV + G
Sbjct: 411 FTSQLKAGKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKTKGFCQLVVSSSLRDG 470
Query: 680 ARALIQATGVGKLAPNVLLMGYKSDW 705
LIQ+ G+G L N +LM + + W
Sbjct: 471 MSHLIQSAGLGGLKHNTVLMAWPASW 496
Score = 59.3 bits (137), Expect = 7e-08
Identities = 31/69 (44%), Positives = 42/69 (60%), Gaps = 4/69 (5%)
Query: 304 NFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKGTLLALLISMVSYAMMVLFTGA--- 360
+F + I+FPSVTGI AG+N SGDLKD +IP GT+LA++ + Y ++ GA
Sbjct: 116 SFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIE 175
Query: 361 -AALRDASG 368
LRD G
Sbjct: 176 GVVLRDKFG 184
Score = 50.0 bits (114), Expect = 4e-05
Identities = 19/46 (41%), Positives = 29/46 (63%), Gaps = 3/46 (6%)
Query: 850 FKRKQE---SGTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIF 892
F + QE G +DVWW+ D G+ +LLP+++ Q W C++RIF
Sbjct: 531 FPQNQERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIF 576
Score = 45.6 bits (103), Expect = 0.001
Identities = 21/63 (33%), Positives = 39/63 (61%)
Query: 974 LRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRGNHTSVLT 1033
++L ++L S+D++L+++++P P K YM +LE+++ L +L VRG V+T
Sbjct: 718 VKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGGGREVIT 777
Query: 1034 FYS 1036
YS
Sbjct: 778 IYS 780
>AF105365-1|AAD39741.1| 1083|Homo sapiens K-Cl cotransporter KCC4
protein.
Length = 1083
Score = 132 bits (319), Expect = 6e-30
Identities = 86/326 (26%), Positives = 141/326 (43%), Gaps = 11/326 (3%)
Query: 389 CANSTLFPCKYGMHVDFEIMQLMSAW-GPFIYA-GCWXXXXXXXXXXXXXVPRLIQALGV 446
C + K+G + ++ M AW P++ G + PRL+QA+
Sbjct: 476 CIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQTLTGAPRLLQAIAR 535
Query: 447 DRIYPGLIFFSKPYGR-HGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFYLASYALIN 505
D I P L F +G+ +GE IA L+++AP++S F+L Y +N
Sbjct: 536 DGIVPFLQVFG--HGKANGEPTWALLLTVLICETGILIASLDSVAPILSMFFLMCYLFVN 593
Query: 506 FCTFHAALVRPLGWRPTFKYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIFFTLYLIVH 565
L+R WRP FK+Y+ +S G +C+ +M + SW +L + I +Y +
Sbjct: 594 LACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIE 653
Query: 566 YRNPDVNWGSSTQAQMYKTALSSAHNLARTGEHVKNYWPQLLVL----GGRAHARPPLVD 621
YR + WG + A + + H KN+ PQ+LV+ +A P L+
Sbjct: 654 YRGAEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPRLLS 713
Query: 622 LGSLITKAGSLMIIGDISKEKLSYKVCSARARADN--EWLQERKVRAFCSLVHGFNFEQG 679
S + L I+G + + K A+ +N + K + FC LV + G
Sbjct: 714 FTSQLKAGKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKTKGFCQLVVSSSLRDG 773
Query: 680 ARALIQATGVGKLAPNVLLMGYKSDW 705
LIQ+ G+G L N +LM + + W
Sbjct: 774 MSHLIQSAGLGGLKHNTVLMAWPASW 799
Score = 116 bits (278), Expect = 6e-25
Identities = 68/210 (32%), Positives = 114/210 (54%), Gaps = 16/210 (7%)
Query: 65 LTREALPRMENYRNSKRALKRPSLGELHGDHLITEEGVLIPCLLNIWGVMLFLRISWVVS 124
L++ + E+ + +R K P +G T GV +PCL NI GV+LFLR++W+V
Sbjct: 95 LSQGVVEHEEDEESRRREAKAPRMG--------TFIGVYLPCLQNILGVILFLRLTWIVG 146
Query: 125 QAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVKGGGIYYIISRSLGPEFGASVGIIFA 184
AG+ S +I+A+ ++T +SMSAI TNG V GG YY+ISRSLGPEFG +VG+ F
Sbjct: 147 VAGVLESFLIVAMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFY 206
Query: 185 FANAVAASMNTIGFCD-SMNHLLKSLDLQIIDNS-------YNDVRIIGAIALFVMCVIC 236
A +M +G + + ++ + + + +++R+ G L +M ++
Sbjct: 207 LGTTFAGAMYILGTIEIFLTYISPGAAIFQAEAAGGEAAAMLHNMRVYGTCTLVLMALVV 266
Query: 237 AVGMDWESKAQNFLIAIIVGAIVDFVVGAV 266
VG+ + +K +A +V +I+ G +
Sbjct: 267 FVGVKYVNKLALVFLACVVLSILAIYAGVI 296
Score = 59.3 bits (137), Expect = 7e-08
Identities = 31/69 (44%), Positives = 42/69 (60%), Gaps = 4/69 (5%)
Query: 304 NFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKGTLLALLISMVSYAMMVLFTGA--- 360
+F + I+FPSVTGI AG+N SGDLKD +IP GT+LA++ + Y ++ GA
Sbjct: 419 SFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIE 478
Query: 361 -AALRDASG 368
LRD G
Sbjct: 479 GVVLRDKFG 487
Score = 50.0 bits (114), Expect = 4e-05
Identities = 19/46 (41%), Positives = 29/46 (63%), Gaps = 3/46 (6%)
Query: 850 FKRKQE---SGTVDVWWLYDDVGLTILLPYIISQRSAWGNCKLRIF 892
F + QE G +DVWW+ D G+ +LLP+++ Q W C++RIF
Sbjct: 834 FPQNQERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIF 879
Score = 45.6 bits (103), Expect = 0.001
Identities = 21/63 (33%), Positives = 39/63 (61%)
Query: 974 LRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRGNHTSVLT 1033
++L ++L S+D++L+++++P P K YM +LE+++ L +L VRG V+T
Sbjct: 1021 VKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGGGREVIT 1080
Query: 1034 FYS 1036
YS
Sbjct: 1081 IYS 1083
>AL162458-6|CAH74053.1| 285|Homo sapiens solute carrier family 12,
(potassium-chloride transporter) member 5 protein.
Length = 285
Score = 115 bits (277), Expect = 8e-25
Identities = 71/221 (32%), Positives = 116/221 (52%), Gaps = 16/221 (7%)
Query: 54 AGWRRKRSLAQLTREALPRMENYRNSKRALKRPSLGELHGDHLITEEGVLIPCLLNIWGV 113
+G +L Q +RE N K+ ++ P +G T GV +PCL NI+GV
Sbjct: 63 SGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRMG--------TFMGVYLPCLQNIFGV 114
Query: 114 MLFLRISWVVSQAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVKGGGIYYIISRSLGP 173
+LFLR++WVV AGI S ++ + ++T +SMSAI TNG V GG YY+ISRSLGP
Sbjct: 115 ILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGP 174
Query: 174 EFGASVGIIFAFANAVAASMNTIGFCD-SMNHLLKSLDLQIIDNS-------YNDVRIIG 225
EFG +VG+ F A +M +G + + +L ++ + +++ N++R+ G
Sbjct: 175 EFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYG 234
Query: 226 AIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAV 266
L M + VG+ + +K + ++ +I+ G +
Sbjct: 235 TCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVI 275
>BC007760-1|AAH07760.1| 266|Homo sapiens SLC12A7 protein protein.
Length = 266
Score = 110 bits (265), Expect = 2e-23
Identities = 57/133 (42%), Positives = 81/133 (60%), Gaps = 8/133 (6%)
Query: 65 LTREALPRMENYRNSKRALKRPSLGELHGDHLITEEGVLIPCLLNIWGVMLFLRISWVVS 124
L++ + E+ + +R K P +G T GV +PCL NI GV+LFLR++W+V
Sbjct: 95 LSQGVVEHEEDEESRRREAKAPRMG--------TFIGVYLPCLQNILGVILFLRLTWIVG 146
Query: 125 QAGIGWSLVIIALSAVVCVITTLSMSAICTNGEVKGGGIYYIISRSLGPEFGASVGIIFA 184
AG+ S +I+A+ ++T +SMSAI TNG V GG YY+ISRSLGPEFG +VG+ F
Sbjct: 147 VAGVLESFLIVAMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFY 206
Query: 185 FANAVAASMNTIG 197
A +M +G
Sbjct: 207 LGTTFAGAMYILG 219
>AK024494-1|BAB15784.1| 672|Homo sapiens FLJ00100 protein protein.
Length = 672
Score = 109 bits (261), Expect = 7e-23
Identities = 73/304 (24%), Positives = 130/304 (42%), Gaps = 4/304 (1%)
Query: 404 DFEIMQLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFSKPYGRH 463
D+ + +S W P + G + R++ AL D ++ ++ +K R
Sbjct: 90 DYGFFRAISLWPPLVLIGIYATALSASMSSLIGASRILHALARDDLFGVILAPAKVVSRG 149
Query: 464 GEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAALVRPLGWRPTF 523
G + KLN +A +++ FYL +YA ++ +RPTF
Sbjct: 150 GNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTF 209
Query: 524 KYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNWGSSTQAQMYK 583
++ L G C+ +M LIS + ++ + L ++ R +WG +QA ++
Sbjct: 210 SLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLAALLTARGGPSSWGYVSQALLFH 269
Query: 584 TALSSAHNLARTGEHVKNYWPQLLVLGGRAHARPPLVDLGSLITKAGSLMIIGDISKEKL 643
L +HVK + PQLL+L G PL+ L + + K G L ++G ++ L
Sbjct: 270 QVRKYLLRLDVRKDHVKFWRPQLLLLVGNPRGALPLLRLANQL-KKGGLYVLGHVTLGDL 328
Query: 644 SYKVCSARARADNEWL---QERKVRAFCSLVHGFNFEQGARALIQATGVGKLAPNVLLMG 700
WL +V+AF L + QGA+ L++ +G+G + PN L++G
Sbjct: 329 DSLPSDPVQPQYGAWLSLVDRAQVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLG 388
Query: 701 YKSD 704
+ D
Sbjct: 389 FYDD 392
Score = 65.7 bits (153), Expect = 8e-10
Identities = 29/58 (50%), Positives = 40/58 (68%)
Query: 297 YSEGMEQNFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKGTLLALLISMVSYAMM 354
Y+ G NF SVFA+ F TGI AGAN+SG+LKDP+ AIP GT++A+ + Y ++
Sbjct: 17 YTTGAVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLL 74
Score = 32.7 bits (71), Expect = 7.0
Identities = 16/38 (42%), Positives = 20/38 (52%)
Query: 989 LIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRG 1026
L + LP P P Y+A LE ++RDL P L V G
Sbjct: 626 LTFLYLPRPPADPARYPRYLALLETLTRDLGPTLLVHG 663
>AK024421-1|BAB15711.1| 772|Homo sapiens FLJ00010 protein protein.
Length = 772
Score = 109 bits (261), Expect = 7e-23
Identities = 73/304 (24%), Positives = 130/304 (42%), Gaps = 4/304 (1%)
Query: 404 DFEIMQLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFSKPYGRH 463
D+ + +S W P + G + R++ AL D ++ ++ +K R
Sbjct: 190 DYGFFRAISLWPPLVLIGIYATALSASMSSLIGASRILHALARDDLFGVILAPAKVVSRG 249
Query: 464 GEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAALVRPLGWRPTF 523
G + KLN +A +++ FYL +YA ++ +RPTF
Sbjct: 250 GNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTF 309
Query: 524 KYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNWGSSTQAQMYK 583
++ L G C+ +M LIS + ++ + L ++ R +WG +QA ++
Sbjct: 310 SLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLAALLTARGGPSSWGYVSQALLFH 369
Query: 584 TALSSAHNLARTGEHVKNYWPQLLVLGGRAHARPPLVDLGSLITKAGSLMIIGDISKEKL 643
L +HVK + PQLL+L G PL+ L + + K G L ++G ++ L
Sbjct: 370 QVRKYLLRLDVRKDHVKFWRPQLLLLVGNPRGALPLLRLANQL-KKGGLYVLGHVTLGDL 428
Query: 644 SYKVCSARARADNEWL---QERKVRAFCSLVHGFNFEQGARALIQATGVGKLAPNVLLMG 700
WL +V+AF L + QGA+ L++ +G+G + PN L++G
Sbjct: 429 DSLPSDPVQPQYGAWLSLVDRAQVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLG 488
Query: 701 YKSD 704
+ D
Sbjct: 489 FYDD 492
Score = 78.6 bits (185), Expect = 1e-13
Identities = 48/160 (30%), Positives = 85/160 (53%), Gaps = 16/160 (10%)
Query: 211 LQIIDNSYNDVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAV-MGP 269
L+++ Y + G++ L ++ +C +G ++A ++ G++ ++ V +GP
Sbjct: 15 LRVLPQGYGWNLLYGSLLLGLVGGVCTLGAGLYARASFLTFLLVSGSLASVLISFVAVGP 74
Query: 270 K------------SNLEVAEG-FVGLSTSTFVENFNSDFK--YSEGMEQNFFSVFAIFFP 314
+ S+L G F G ++ST +N + + Y+ G NF SVFA+ F
Sbjct: 75 RDIRLTPRPGPNGSSLPPRFGHFTGFNSSTLKDNLGAGYAEDYTTGAVMNFASVFAVLFN 134
Query: 315 SVTGIQAGANISGDLKDPASAIPKGTLLALLISMVSYAMM 354
TGI AGAN+SG+LKDP+ AIP GT++A+ + Y ++
Sbjct: 135 GCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLL 174
Score = 32.7 bits (71), Expect = 7.0
Identities = 16/38 (42%), Positives = 20/38 (52%)
Query: 989 LIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRG 1026
L + LP P P Y+A LE ++RDL P L V G
Sbjct: 726 LTFLYLPRPPADPARYPRYLALLETLTRDLGPTLLVHG 763
>AF389851-1|AAK94307.1| 584|Homo sapiens solute carrier family 12
member 8 protein.
Length = 584
Score = 95.9 bits (228), Expect = 7e-19
Identities = 63/178 (35%), Positives = 96/178 (53%), Gaps = 15/178 (8%)
Query: 189 VAASMNTIGFCDSMNHLLKSLDLQIIDNSYNDVRIIGAIALFVMCVICAVGMDWESKAQN 248
VA +M GF +S++ LL + N + VR I L + I G+ W Q
Sbjct: 2 VAGAMYITGFAESISDLLG------LGNIWA-VRGISVAVLLALLGINLAGVKWIICLQL 54
Query: 249 FLIAIIVGAIVDFVVGAVMGPKSNLEVAEGFVGLSTSTFVENFNSDFKYSEGMEQNFFSV 308
L+ ++ + +DFVVG+ ++L+ GF+G S N D YS G ++FF+V
Sbjct: 55 LLLFLLAVSTLDFVVGSF----THLDPEHGFIGYSPELLQNNTLPD--YSPG--ESFFTV 106
Query: 309 FAIFFPSVTGIQAGANISGDLKDPASAIPKGTLLALLISMVSYAMMVLFTGAAALRDA 366
F +FFP+ TG+ AG N+ GDL++PA++IP G+L A+ IS Y + V GA R+A
Sbjct: 107 FGVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREA 164
Score = 41.1 bits (92), Expect = 0.020
Identities = 19/69 (27%), Positives = 37/69 (53%), Gaps = 4/69 (5%)
Query: 519 WRPTFKYY----NVWVSLAGFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNWG 574
WR + +Y N WVSL G + + IM +I W+ +LV + + +Y + +P ++ G
Sbjct: 452 WRRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLG 511
Query: 575 SSTQAQMYK 583
S++ ++
Sbjct: 512 SASNFSFFR 520
Score = 36.3 bits (80), Expect = 0.57
Identities = 17/113 (15%), Positives = 44/113 (38%)
Query: 401 MHVDFEIMQLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFSKPY 460
+ DF I + +S G G + PR++Q + +++ P L +
Sbjct: 165 LRYDFLIAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGK 224
Query: 461 GRHGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAAL 513
G + + ++N +AP+++ ++ +Y +++ F ++
Sbjct: 225 GPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSM 277
>BC000154-1|AAH00154.1| 538|Homo sapiens SLC12A9 protein protein.
Length = 538
Score = 93.9 bits (223), Expect = 3e-18
Identities = 67/289 (23%), Positives = 120/289 (41%), Gaps = 4/289 (1%)
Query: 404 DFEIMQLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFSKPYGRH 463
D+ + +S W P + G + R++ AL D ++ ++ +K R
Sbjct: 243 DYGFFRAISLWPPLVLIGIYATALSASMSSLIGASRILHALARDDLFGVILAPAKVVSRG 302
Query: 464 GEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAALVRPLGWRPTF 523
G + KLN +A +++ FYL +YA ++ +RPTF
Sbjct: 303 GNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTF 362
Query: 524 KYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNWGSSTQAQMYK 583
++ L G C+ +M LIS + ++ + L ++ R +WG +QA ++
Sbjct: 363 SLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLAALLTARGGPSSWGYVSQALLFH 422
Query: 584 TALSSAHNLARTGEHVKNYWPQLLVLGGRAHARPPLVDLGSLITKAGSLMIIGDISKEKL 643
L +HVK + PQLL+L G PL+ L + + K G L ++G ++ L
Sbjct: 423 QVRKYLLRLDVRKDHVKFWRPQLLLLVGNPRGALPLLRLANQL-KKGGLYVLGHVTLGDL 481
Query: 644 SYKVCSARARADNEWL---QERKVRAFCSLVHGFNFEQGARALIQATGV 689
WL +V+AF L + QGA+ L++ +G+
Sbjct: 482 DSLPSDPVQPQYGAWLSLVDRAQVKAFVDLTLSPSVRQGAQHLLRISGL 530
Score = 78.6 bits (185), Expect = 1e-13
Identities = 48/160 (30%), Positives = 85/160 (53%), Gaps = 16/160 (10%)
Query: 211 LQIIDNSYNDVRIIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAV-MGP 269
L+++ Y + G++ L ++ +C +G ++A ++ G++ ++ V +GP
Sbjct: 68 LRVLPQGYGWNLLYGSLLLGLVGGVCTLGAGLYARASFLTFLLVSGSLASVLISFVAVGP 127
Query: 270 K------------SNLEVAEG-FVGLSTSTFVENFNSDFK--YSEGMEQNFFSVFAIFFP 314
+ S+L G F G ++ST +N + + Y+ G NF SVFA+ F
Sbjct: 128 RDIRLTPRPGPNGSSLPPRFGHFTGFNSSTLKDNLGAGYAEDYTTGAVMNFASVFAVLFN 187
Query: 315 SVTGIQAGANISGDLKDPASAIPKGTLLALLISMVSYAMM 354
TGI AGAN+SG+LKDP+ AIP GT++A+ + Y ++
Sbjct: 188 GCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLL 227
>AK090458-1|BAC03439.1| 487|Homo sapiens FLJ00379 protein protein.
Length = 487
Score = 91.9 bits (218), Expect = 1e-17
Identities = 61/223 (27%), Positives = 105/223 (47%), Gaps = 4/223 (1%)
Query: 485 KLNAIAPLISNFYLASYALINFCTFHAALVRPLGWRPTFKYYNVWVSLAGFLMCVGIMLL 544
KLN +A +++ FYL +YA ++ +RPTF ++ L G C+ +M L
Sbjct: 39 KLNTLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFL 98
Query: 545 ISWIMSLVTIAIFFTLYLIVHYRNPDVNWGSSTQAQMYKTALSSAHNLARTGEHVKNYWP 604
IS + ++ + L ++ R +WG +QA ++ L +HVK + P
Sbjct: 99 ISPGAAGGSLLLMGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRP 158
Query: 605 QLLVLGGRAHARPPLVDLGSLITKAGSLMIIGDISKEKLSYKVCSARARADNEWL---QE 661
QLL+L G PL+ L + + K G L ++G ++ L WL
Sbjct: 159 QLLLLVGNPRGALPLLRLANQL-KKGGLYVLGHVTLGDLDSLPSDPVQPQYGAWLSLVDR 217
Query: 662 RKVRAFCSLVHGFNFEQGARALIQATGVGKLAPNVLLMGYKSD 704
+V+AF L + QGA+ L++ +G+G + PN L++G+ D
Sbjct: 218 AQVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGFYDD 260
>AK024420-1|BAB15710.1| 540|Homo sapiens FLJ00009 protein protein.
Length = 540
Score = 91.9 bits (218), Expect = 1e-17
Identities = 61/223 (27%), Positives = 105/223 (47%), Gaps = 4/223 (1%)
Query: 485 KLNAIAPLISNFYLASYALINFCTFHAALVRPLGWRPTFKYYNVWVSLAGFLMCVGIMLL 544
KLN +A +++ FYL +YA ++ +RPTF ++ L G C+ +M L
Sbjct: 39 KLNTLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFL 98
Query: 545 ISWIMSLVTIAIFFTLYLIVHYRNPDVNWGSSTQAQMYKTALSSAHNLARTGEHVKNYWP 604
IS + ++ + L ++ R +WG +QA ++ L +HVK + P
Sbjct: 99 ISPGAAGGSLLLMGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRP 158
Query: 605 QLLVLGGRAHARPPLVDLGSLITKAGSLMIIGDISKEKLSYKVCSARARADNEWL---QE 661
QLL+L G PL+ L + + K G L ++G ++ L WL
Sbjct: 159 QLLLLVGNPRGALPLLRLANQL-KKGGLYVLGHVTLGDLDSLPSDPVQPQYGAWLSLVDR 217
Query: 662 RKVRAFCSLVHGFNFEQGARALIQATGVGKLAPNVLLMGYKSD 704
+V+AF L + QGA+ L++ +G+G + PN L++G+ D
Sbjct: 218 AQVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGFYDD 260
Score = 32.7 bits (71), Expect = 7.0
Identities = 16/38 (42%), Positives = 20/38 (52%)
Query: 989 LIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRG 1026
L + LP P P Y+A LE ++RDL P L V G
Sbjct: 494 LTFLYLPRPPADPARYPRYLALLETLTRDLGPTLLVHG 531
>AB209192-1|BAD92429.1| 122|Homo sapiens solute carrier family 12
(sodium/potassium/chloride transporters), member 2 var
protein.
Length = 122
Score = 81.0 bits (191), Expect = 2e-14
Identities = 42/118 (35%), Positives = 65/118 (55%), Gaps = 2/118 (1%)
Query: 604 PQLLVLGGRAHARPPLVDLGSLITKAGSLMIIGDI--SKEKLSYKVCSARARADNEWLQE 661
PQ LV+ G ++RP L+ L TK LMI G + + + K S WL +
Sbjct: 3 PQCLVMTGAPNSRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSIDQAKYQRWLIK 62
Query: 662 RKVRAFCSLVHGFNFEQGARALIQATGVGKLAPNVLLMGYKSDWTTASAEDLVAYFNV 719
K++AF + VH + +GA+ L+QA G+G++ PN L++G+K DW A D+ Y N+
Sbjct: 63 NKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQADMRDVDMYINL 120
>AK024466-1|BAB15756.1| 477|Homo sapiens FLJ00059 protein protein.
Length = 477
Score = 72.5 bits (170), Expect = 7e-12
Identities = 51/187 (27%), Positives = 87/187 (46%), Gaps = 4/187 (2%)
Query: 521 PTFKYYNVWVSLAGFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNWGSSTQAQ 580
PTF ++ L G C+ +M LIS + ++ + L ++ R +WG +QA
Sbjct: 12 PTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLAALLTARGGPSSWGYVSQAL 71
Query: 581 MYKTALSSAHNLARTGEHVKNYWPQLLVLGGRAHARPPLVDLGSLITKAGSLMIIGDISK 640
++ L +HVK + PQLL+L G PL+ L + + K G L ++G ++
Sbjct: 72 LFHQVRKYLLRLDVRKDHVKFWRPQLLLLVGNPRGALPLLRLANQL-KKGGLYVLGHVTL 130
Query: 641 EKLSYKVCSARARADNEWL---QERKVRAFCSLVHGFNFEQGARALIQATGVGKLAPNVL 697
L WL +V+AF L + QGA+ L++ +G+G + PN L
Sbjct: 131 GDLDSLPSDPVQPQYGAWLSLVDRAQVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTL 190
Query: 698 LMGYKSD 704
++G+ D
Sbjct: 191 VLGFYDD 197
Score = 32.7 bits (71), Expect = 7.0
Identities = 16/38 (42%), Positives = 20/38 (52%)
Query: 989 LIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRG 1026
L + LP P P Y+A LE ++RDL P L V G
Sbjct: 431 LTFLYLPRPPADPARYPRYLALLETLTRDLGPTLLVHG 468
>AF053402-1|AAC35282.1| 238|Homo sapiens erythrocyte K-Cl
cotransporter protein.
Length = 238
Score = 50.0 bits (114), Expect = 4e-05
Identities = 31/76 (40%), Positives = 41/76 (53%), Gaps = 1/76 (1%)
Query: 304 NFFSVFAIFFPSVTGIQAGANISGDLKDPASAIPKGTLLALLISMVSYAMMVLFTGAAAL 363
+F + IFFPSVTGI AG+N SGDL+D +IP G L + S V F+ AL
Sbjct: 140 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGPFWPSL-QLPSCTSAVWFSLVPAL 198
Query: 364 RDASGNITDLVISNGT 379
R + ++S GT
Sbjct: 199 RVWFSRTSMAMVSAGT 214
>BX538023-1|CAD97969.1| 525|Homo sapiens hypothetical protein
protein.
Length = 525
Score = 49.2 bits (112), Expect = 8e-05
Identities = 22/51 (43%), Positives = 34/51 (66%)
Query: 316 VTGIQAGANISGDLKDPASAIPKGTLLALLISMVSYAMMVLFTGAAALRDA 366
++G+ AG N+ GDL++PA++IP G+L A+ IS Y + V GA R+A
Sbjct: 55 LSGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREA 105
Score = 41.1 bits (92), Expect = 0.020
Identities = 19/69 (27%), Positives = 37/69 (53%), Gaps = 4/69 (5%)
Query: 519 WRPTFKYY----NVWVSLAGFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNWG 574
WR + +Y N WVSL G + + IM +I W+ +LV + + +Y + +P ++ G
Sbjct: 393 WRRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLG 452
Query: 575 SSTQAQMYK 583
S++ ++
Sbjct: 453 SASNFSFFR 461
Score = 36.3 bits (80), Expect = 0.57
Identities = 17/113 (15%), Positives = 44/113 (38%)
Query: 401 MHVDFEIMQLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFSKPY 460
+ DF I + +S G G + PR++Q + +++ P L +
Sbjct: 106 LRYDFLIAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGK 165
Query: 461 GRHGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAAL 513
G + + ++N +AP+++ ++ +Y +++ F ++
Sbjct: 166 GPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSM 218
>AL117433-1|CAB55921.1| 186|Homo sapiens hypothetical protein
protein.
Length = 186
Score = 45.6 bits (103), Expect = 0.001
Identities = 21/63 (33%), Positives = 39/63 (61%)
Query: 974 LRLRELLLANSRDSRLIVMSLPMPRKGSVSAPLYMAWLEMMSRDLPPMLFVRGNHTSVLT 1033
++L ++L S+D++L+++++P P K YM +LE+++ L +L VRG V+T
Sbjct: 124 VKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGGGREVIT 183
Query: 1034 FYS 1036
YS
Sbjct: 184 IYS 186
>CR457363-1|CAG33644.1| 308|Homo sapiens SLC12A8 protein.
Length = 308
Score = 41.1 bits (92), Expect = 0.020
Identities = 19/69 (27%), Positives = 37/69 (53%), Gaps = 4/69 (5%)
Query: 519 WRPTFKYY----NVWVSLAGFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNWG 574
WR + +Y N WVSL G + + IM +I W+ +LV + + +Y + +P ++ G
Sbjct: 176 WRRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLG 235
Query: 575 SSTQAQMYK 583
S++ ++
Sbjct: 236 SASNFSFFR 244
>BC020506-1|AAH20506.1| 308|Homo sapiens SLC12A8 protein protein.
Length = 308
Score = 41.1 bits (92), Expect = 0.020
Identities = 19/69 (27%), Positives = 37/69 (53%), Gaps = 4/69 (5%)
Query: 519 WRPTFKYY----NVWVSLAGFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNWG 574
WR + +Y N WVSL G + + IM +I W+ +LV + + +Y + +P ++ G
Sbjct: 176 WRRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLG 235
Query: 575 SSTQAQMYK 583
S++ ++
Sbjct: 236 SASNFSFFR 244
>AK026841-1|BAB15571.1| 308|Homo sapiens protein ( Homo sapiens
cDNA: FLJ23188 fis, clone LNG12038. ).
Length = 308
Score = 41.1 bits (92), Expect = 0.020
Identities = 19/69 (27%), Positives = 37/69 (53%), Gaps = 4/69 (5%)
Query: 519 WRPTFKYY----NVWVSLAGFLMCVGIMLLISWIMSLVTIAIFFTLYLIVHYRNPDVNWG 574
WR + +Y N WVSL G + + IM +I W+ +LV + + +Y + +P ++ G
Sbjct: 176 WRRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLG 235
Query: 575 SSTQAQMYK 583
S++ ++
Sbjct: 236 SASNFSFFR 244
>AJ005333-1|CAA06480.1| 31|Homo sapiens Na-K-2Cl cotransporter
protein.
Length = 31
Score = 40.7 bits (91), Expect = 0.026
Identities = 18/29 (62%), Positives = 23/29 (79%)
Query: 132 LVIIALSAVVCVITTLSMSAICTNGEVKG 160
++II LS VV +T +SMSAICTNG V+G
Sbjct: 3 VIIIGLSVVVTTLTGISMSAICTNGVVRG 31
>AB032527-1|BAA84576.1| 31|Homo sapiens Na-K-2Cl cotransporter
isoform IV protein.
Length = 31
Score = 40.7 bits (91), Expect = 0.026
Identities = 18/29 (62%), Positives = 23/29 (79%)
Query: 132 LVIIALSAVVCVITTLSMSAICTNGEVKG 160
++II LS VV +T +SMSAICTNG V+G
Sbjct: 3 VIIIGLSVVVTTLTGISMSAICTNGVVRG 31
>BC063528-1|AAH63528.1| 338|Homo sapiens SLC12A8 protein protein.
Length = 338
Score = 39.1 bits (87), Expect = 0.080
Identities = 18/42 (42%), Positives = 27/42 (64%)
Query: 325 ISGDLKDPASAIPKGTLLALLISMVSYAMMVLFTGAAALRDA 366
+ GDL++PA++IP G+L A+ IS Y + V GA R+A
Sbjct: 1 MGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREA 42
Score = 36.3 bits (80), Expect = 0.57
Identities = 17/113 (15%), Positives = 44/113 (38%)
Query: 401 MHVDFEIMQLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFSKPY 460
+ DF I + +S G G + PR++Q + +++ P L +
Sbjct: 43 LRYDFLIAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGK 102
Query: 461 GRHGEAYRGYXXXXXXXXXXXXIAKLNAIAPLISNFYLASYALINFCTFHAAL 513
G + + ++N +AP+++ ++ +Y +++ F ++
Sbjct: 103 GPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSM 155
>BC012087-1|AAH12087.1| 501|Homo sapiens solute carrier family 7,
(cationic amino acid transporter, y+ system) member 11
protein.
Length = 501
Score = 37.5 bits (83), Expect = 0.25
Identities = 37/160 (23%), Positives = 73/160 (45%), Gaps = 7/160 (4%)
Query: 110 IWGVMLFLRISWVVSQAG-IGWSLVIIALSAVVCVITTLSMSAICTNGEVKGGGIYYIIS 168
I G +F+ V+ G +G SL I + V+ + LS + + T + GG YI+
Sbjct: 57 IIGAGIFISPKGVLQNTGSVGMSLTIWTVCGVLSLFGALSYAELGTTIKKSGGHYTYIL- 115
Query: 169 RSLGP-EFGASVGIIFAFANAVAASMNTIGFCDSMNHLLKSLDLQIIDNSYNDVRIIGAI 227
GP V + A ++ ++ F ++L+ +Q + +++I A+
Sbjct: 116 EVFGPLPAFVRVWVELLIIRPAATAVISLAF---GRYILEPFFIQ-CEIPELAIKLITAV 171
Query: 228 ALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAVM 267
+ V+ V+ ++ + W ++ Q FL + AI+ +V VM
Sbjct: 172 GITVVMVLNSMSVSWSARIQIFLTFCKLTAILIIIVPGVM 211
>AJ277882-1|CAC81905.1| 501|Homo sapiens cystine/glutamate
transporter protein.
Length = 501
Score = 37.5 bits (83), Expect = 0.25
Identities = 37/160 (23%), Positives = 73/160 (45%), Gaps = 7/160 (4%)
Query: 110 IWGVMLFLRISWVVSQAG-IGWSLVIIALSAVVCVITTLSMSAICTNGEVKGGGIYYIIS 168
I G +F+ V+ G +G SL I + V+ + LS + + T + GG YI+
Sbjct: 57 IIGAGIFISPKGVLQNTGSVGMSLTIWTVCGVLSLFGALSYAELGTTIKKSGGHYTYIL- 115
Query: 169 RSLGP-EFGASVGIIFAFANAVAASMNTIGFCDSMNHLLKSLDLQIIDNSYNDVRIIGAI 227
GP V + A ++ ++ F ++L+ +Q + +++I A+
Sbjct: 116 EVFGPLPAFVRVWVELLIIRPAATAVISLAF---GRYILEPFFIQ-CEIPELAIKLITAV 171
Query: 228 ALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAVM 267
+ V+ V+ ++ + W ++ Q FL + AI+ +V VM
Sbjct: 172 GITVVMVLNSMSVSWSARIQIFLTFCKLTAILIIIVPGVM 211
>AF252872-1|AAK49111.1| 501|Homo sapiens cystine/glutamate
transporter xCT protein.
Length = 501
Score = 37.5 bits (83), Expect = 0.25
Identities = 37/160 (23%), Positives = 73/160 (45%), Gaps = 7/160 (4%)
Query: 110 IWGVMLFLRISWVVSQAG-IGWSLVIIALSAVVCVITTLSMSAICTNGEVKGGGIYYIIS 168
I G +F+ V+ G +G SL I + V+ + LS + + T + GG YI+
Sbjct: 57 IIGAGIFISPKGVLQNTGSVGMSLTIWTVCGVLSLFGALSYAELGTTIKKSGGHYTYIL- 115
Query: 169 RSLGP-EFGASVGIIFAFANAVAASMNTIGFCDSMNHLLKSLDLQIIDNSYNDVRIIGAI 227
GP V + A ++ ++ F ++L+ +Q + +++I A+
Sbjct: 116 EVFGPLPAFVRVWVELLIIRPAATAVISLAF---GRYILEPFFIQ-CEIPELAIKLITAV 171
Query: 228 ALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAVM 267
+ V+ V+ ++ + W ++ Q FL + AI+ +V VM
Sbjct: 172 GITVVMVLNSMSVSWSARIQIFLTFCKLTAILIIIVPGVM 211
>AF200708-1|AAG35592.1| 501|Homo sapiens calcium channel blocker
resistance protein CCBR1 protein.
Length = 501
Score = 37.5 bits (83), Expect = 0.25
Identities = 37/160 (23%), Positives = 73/160 (45%), Gaps = 7/160 (4%)
Query: 110 IWGVMLFLRISWVVSQAG-IGWSLVIIALSAVVCVITTLSMSAICTNGEVKGGGIYYIIS 168
I G +F+ V+ G +G SL I + V+ + LS + + T + GG YI+
Sbjct: 57 IIGAGIFISPKGVLQNTGSVGMSLTIWTVCGVLSLFGALSYAELGTTIKKSGGHYTYIL- 115
Query: 169 RSLGP-EFGASVGIIFAFANAVAASMNTIGFCDSMNHLLKSLDLQIIDNSYNDVRIIGAI 227
GP V + A ++ ++ F ++L+ +Q + +++I A+
Sbjct: 116 EVFGPLPAFVRVWVELLIIRPAATAVISLAF---GRYILEPFFIQ-CEIPELAIKLITAV 171
Query: 228 ALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAVM 267
+ V+ V+ ++ + W ++ Q FL + AI+ +V VM
Sbjct: 172 GITVVMVLNSMSVSWSARIQIFLTFCKLTAILIIIVPGVM 211
>AB040875-1|BAB40574.1| 494|Homo sapiens cystine/glutamate
exchanger protein.
Length = 494
Score = 37.5 bits (83), Expect = 0.25
Identities = 37/160 (23%), Positives = 73/160 (45%), Gaps = 7/160 (4%)
Query: 110 IWGVMLFLRISWVVSQAG-IGWSLVIIALSAVVCVITTLSMSAICTNGEVKGGGIYYIIS 168
I G +F+ V+ G +G SL I + V+ + LS + + T + GG YI+
Sbjct: 57 IIGAGIFISPKGVLQNTGSVGMSLTIWTVCGVLSLFGALSYAELGTTIKKSGGHYTYIL- 115
Query: 169 RSLGP-EFGASVGIIFAFANAVAASMNTIGFCDSMNHLLKSLDLQIIDNSYNDVRIIGAI 227
GP V + A ++ ++ F ++L+ +Q + +++I A+
Sbjct: 116 EVFGPLPAFVRVWVELLIIRPAATAVISLAF---GRYILEPFFIQ-CEIPELAIKLITAV 171
Query: 228 ALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAVM 267
+ V+ V+ ++ + W ++ Q FL + AI+ +V VM
Sbjct: 172 GITVVMVLNSMSVSWSARIQIFLTFCKLTAILIIIVPGVM 211
>AB026891-1|BAA82628.1| 501|Homo sapiens cystine/glutamate
transporter protein.
Length = 501
Score = 37.5 bits (83), Expect = 0.25
Identities = 37/160 (23%), Positives = 73/160 (45%), Gaps = 7/160 (4%)
Query: 110 IWGVMLFLRISWVVSQAG-IGWSLVIIALSAVVCVITTLSMSAICTNGEVKGGGIYYIIS 168
I G +F+ V+ G +G SL I + V+ + LS + + T + GG YI+
Sbjct: 57 IIGAGIFISPKGVLQNTGSVGMSLTIWTVCGVLSLFGALSYAELGTTIKKSGGHYTYIL- 115
Query: 169 RSLGP-EFGASVGIIFAFANAVAASMNTIGFCDSMNHLLKSLDLQIIDNSYNDVRIIGAI 227
GP V + A ++ ++ F ++L+ +Q + +++I A+
Sbjct: 116 EVFGPLPAFVRVWVELLIIRPAATAVISLAF---GRYILEPFFIQ-CEIPELAIKLITAV 171
Query: 228 ALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVVGAVM 267
+ V+ V+ ++ + W ++ Q FL + AI+ +V VM
Sbjct: 172 GITVVMVLNSMSVSWSARIQIFLTFCKLTAILIIIVPGVM 211
>X59155-1|CAA41869.1| 629|Homo sapiens retroviral receptor protein.
Length = 629
Score = 34.7 bits (76), Expect = 1.7
Identities = 35/137 (25%), Positives = 58/137 (42%), Gaps = 9/137 (6%)
Query: 223 IIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVV--GAVMGPKSNLEVAE-GF 279
I I + ++ + +G+ ES N + I ++ F++ G V G N ++ E F
Sbjct: 166 IFAVIIILILTGLLTLGVK-ESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDF 224
Query: 280 VGLSTSTFVENFNSDFKYSEG--MEQNFFSVF---AIFFPSVTGIQAGANISGDLKDPAS 334
S + N + K G M F V A F + G A ++K+P
Sbjct: 225 GNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQK 284
Query: 335 AIPKGTLLALLISMVSY 351
AIP G + +LLI ++Y
Sbjct: 285 AIPVGIVASLLICFIAY 301
>X57303-1|CAA40560.1| 629|Homo sapiens REC1L protein.
Length = 629
Score = 34.7 bits (76), Expect = 1.7
Identities = 35/137 (25%), Positives = 58/137 (42%), Gaps = 9/137 (6%)
Query: 223 IIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVV--GAVMGPKSNLEVAE-GF 279
I I + ++ + +G+ ES N + I ++ F++ G V G N ++ E F
Sbjct: 166 IFAVIIILILTGLLTLGVK-ESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDF 224
Query: 280 VGLSTSTFVENFNSDFKYSEG--MEQNFFSVF---AIFFPSVTGIQAGANISGDLKDPAS 334
S + N + K G M F V A F + G A ++K+P
Sbjct: 225 GNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQK 284
Query: 335 AIPKGTLLALLISMVSY 351
AIP G + +LLI ++Y
Sbjct: 285 AIPVGIVASLLICFIAY 301
>BC115407-1|AAI15408.1| 629|Homo sapiens solute carrier family 7
(cationic amino acid transporter, y+ system), member 1
protein.
Length = 629
Score = 34.7 bits (76), Expect = 1.7
Identities = 35/137 (25%), Positives = 58/137 (42%), Gaps = 9/137 (6%)
Query: 223 IIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVV--GAVMGPKSNLEVAE-GF 279
I I + ++ + +G+ ES N + I ++ F++ G V G N ++ E F
Sbjct: 166 IFAVIIILILTGLLTLGVK-ESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDF 224
Query: 280 VGLSTSTFVENFNSDFKYSEG--MEQNFFSVF---AIFFPSVTGIQAGANISGDLKDPAS 334
S + N + K G M F V A F + G A ++K+P
Sbjct: 225 GNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQK 284
Query: 335 AIPKGTLLALLISMVSY 351
AIP G + +LLI ++Y
Sbjct: 285 AIPVGIVASLLICFIAY 301
>BC069358-1|AAH69358.1| 629|Homo sapiens solute carrier family 7
(cationic amino acid transporter, y+ system), member 1
protein.
Length = 629
Score = 34.7 bits (76), Expect = 1.7
Identities = 35/137 (25%), Positives = 58/137 (42%), Gaps = 9/137 (6%)
Query: 223 IIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVV--GAVMGPKSNLEVAE-GF 279
I I + ++ + +G+ ES N + I ++ F++ G V G N ++ E F
Sbjct: 166 IFAVIIILILTGLLTLGVK-ESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDF 224
Query: 280 VGLSTSTFVENFNSDFKYSEG--MEQNFFSVF---AIFFPSVTGIQAGANISGDLKDPAS 334
S + N + K G M F V A F + G A ++K+P
Sbjct: 225 GNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQK 284
Query: 335 AIPKGTLLALLISMVSY 351
AIP G + +LLI ++Y
Sbjct: 285 AIPVGIVASLLICFIAY 301
>BC063303-1|AAH63303.1| 629|Homo sapiens solute carrier family 7
(cationic amino acid transporter, y+ system), member 1
protein.
Length = 629
Score = 34.7 bits (76), Expect = 1.7
Identities = 35/137 (25%), Positives = 58/137 (42%), Gaps = 9/137 (6%)
Query: 223 IIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVV--GAVMGPKSNLEVAE-GF 279
I I + ++ + +G+ ES N + I ++ F++ G V G N ++ E F
Sbjct: 166 IFAVIIILILTGLLTLGVK-ESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDF 224
Query: 280 VGLSTSTFVENFNSDFKYSEG--MEQNFFSVF---AIFFPSVTGIQAGANISGDLKDPAS 334
S + N + K G M F V A F + G A ++K+P
Sbjct: 225 GNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQK 284
Query: 335 AIPKGTLLALLISMVSY 351
AIP G + +LLI ++Y
Sbjct: 285 AIPVGIVASLLICFIAY 301
>AL596114-3|CAI39913.1| 629|Homo sapiens solute carrier family 7
(cationic amino acid transporter, y+ system), member 1
protein.
Length = 629
Score = 34.7 bits (76), Expect = 1.7
Identities = 35/137 (25%), Positives = 58/137 (42%), Gaps = 9/137 (6%)
Query: 223 IIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVV--GAVMGPKSNLEVAE-GF 279
I I + ++ + +G+ ES N + I ++ F++ G V G N ++ E F
Sbjct: 166 IFAVIIILILTGLLTLGVK-ESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDF 224
Query: 280 VGLSTSTFVENFNSDFKYSEG--MEQNFFSVF---AIFFPSVTGIQAGANISGDLKDPAS 334
S + N + K G M F V A F + G A ++K+P
Sbjct: 225 GNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQK 284
Query: 335 AIPKGTLLALLISMVSY 351
AIP G + +LLI ++Y
Sbjct: 285 AIPVGIVASLLICFIAY 301
>AF078107-1|AAC27721.1| 629|Homo sapiens cationic amino acid
transporter protein.
Length = 629
Score = 34.7 bits (76), Expect = 1.7
Identities = 35/137 (25%), Positives = 58/137 (42%), Gaps = 9/137 (6%)
Query: 223 IIGAIALFVMCVICAVGMDWESKAQNFLIAIIVGAIVDFVV--GAVMGPKSNLEVAE-GF 279
I I + ++ + +G+ ES N + I ++ F++ G V G N ++ E F
Sbjct: 166 IFAVIIILILTGLLTLGVK-ESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDF 224
Query: 280 VGLSTSTFVENFNSDFKYSEG--MEQNFFSVF---AIFFPSVTGIQAGANISGDLKDPAS 334
S + N + K G M F V A F + G A ++K+P
Sbjct: 225 GNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQK 284
Query: 335 AIPKGTLLALLISMVSY 351
AIP G + +LLI ++Y
Sbjct: 285 AIPVGIVASLLICFIAY 301
>AJ005332-1|CAA06479.1| 31|Homo sapiens Na-K-2Cl cotransporter
protein.
Length = 31
Score = 32.7 bits (71), Expect = 7.0
Identities = 17/29 (58%), Positives = 21/29 (72%)
Query: 132 LVIIALSAVVCVITTLSMSAICTNGEVKG 160
++II LS +V IT LS SAI TNG V+G
Sbjct: 3 VLIILLSTMVTSITGLSTSAIATNGFVRG 31
>AB032525-1|BAA84574.1| 31|Homo sapiens Na-K-2Cl cotransporter
protein.
Length = 31
Score = 32.7 bits (71), Expect = 7.0
Identities = 17/29 (58%), Positives = 21/29 (72%)
Query: 132 LVIIALSAVVCVITTLSMSAICTNGEVKG 160
++II LS +V IT LS SAI TNG V+G
Sbjct: 3 VLIILLSTMVTSITGLSTSAIATNGFVRG 31
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.323 0.136 0.410
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 134,941,704
Number of Sequences: 224733
Number of extensions: 5045706
Number of successful extensions: 17618
Number of sequences better than 10.0: 80
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 17228
Number of HSP's gapped (non-prelim): 269
length of query: 1036
length of database: 73,234,838
effective HSP length: 97
effective length of query: 939
effective length of database: 51,435,737
effective search space: 48298157043
effective search space used: 48298157043
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (22.0 bits)
S2: 70 (32.3 bits)
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