Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001458-TA|BGIBMGA001458-PA|IPR002290|Serine/threonine
protein kinase, IPR000719|Protein kinase, IPR008271|Serine/threonine
protein kinase, active site, IPR011009|Protein kinase-like
(403 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
L05624-1|AAA36318.1| 393|Homo sapiens MAP kinase kinase protein. 545 e-154
BC139729-1|AAI39730.1| 393|Homo sapiens mitogen-activated prote... 545 e-154
BC018645-1|AAH18645.1| 400|Homo sapiens mitogen-activated prote... 526 e-149
BC000471-1|AAH00471.1| 400|Homo sapiens mitogen-activated prote... 526 e-149
BC067760-1|AAH67760.1| 380|Homo sapiens LOC407835 protein protein. 471 e-132
BX538081-1|CAD98005.1| 303|Homo sapiens hypothetical protein pr... 440 e-123
U71087-1|AAB16851.1| 448|Homo sapiens MAP kinase kinase MEK5b p... 256 1e-67
CR542229-1|CAG47025.1| 448|Homo sapiens MAP2K5 protein. 256 1e-67
BT006780-1|AAP35426.1| 448|Homo sapiens mitogen-activated prote... 256 1e-67
BC008838-1|AAH08838.1| 448|Homo sapiens mitogen-activated prote... 256 1e-67
U71088-1|AAB16852.2| 444|Homo sapiens MAP kinase kinase MEK5c p... 216 1e-55
U25265-1|AAA96146.1| 438|Homo sapiens MEK5 protein. 216 1e-55
BC038295-1|AAH38295.1| 426|Homo sapiens MAP2K7 protein protein. 194 5e-49
U17743-1|AAC50127.1| 399|Homo sapiens JNK activating kinase pro... 194 6e-49
L36870-1|AAC41719.1| 399|Homo sapiens MAP kinase kinase 4 protein. 194 6e-49
DQ015703-1|AAY22176.1| 399|Homo sapiens mitogen-activated prote... 194 6e-49
BT019676-1|AAV38482.1| 399|Homo sapiens mitogen-activated prote... 194 6e-49
BC060764-1|AAH60764.1| 399|Homo sapiens mitogen-activated prote... 194 6e-49
BC036032-1|AAH36032.1| 399|Homo sapiens mitogen-activated prote... 194 6e-49
AF070090-1|AAC24130.1| 399|Homo sapiens mitogen-activated prote... 194 6e-49
CR536564-1|CAG38801.1| 399|Homo sapiens MAP2K4 protein. 192 1e-48
X96757-1|CAA65532.1| 334|Homo sapiens MAP kinase kinase protein. 184 4e-46
U49732-1|AAB05035.1| 334|Homo sapiens MAP kinase kinase MEK6 pr... 184 4e-46
U39657-1|AAC50389.1| 334|Homo sapiens MAP kinase kinase 6 protein. 184 4e-46
U39656-1|AAC50388.1| 334|Homo sapiens MAP kinase kinase 6 protein. 184 4e-46
D87905-1|BAA13496.1| 334|Homo sapiens mitogen-activated protein... 184 4e-46
BC012009-1|AAH12009.1| 334|Homo sapiens mitogen-activated prote... 184 4e-46
U39065-1|AAB03705.1| 334|Homo sapiens MAP kinase kinase 6b prot... 184 7e-46
U18297-1|AAA83254.1| 487|Homo sapiens MST1 protein. 180 6e-45
Z93016-2|CAI19815.1| 487|Homo sapiens serine/threonine kinase 4... 180 8e-45
Z93016-1|CAB07508.2| 462|Homo sapiens serine/threonine kinase 4... 180 8e-45
U60207-1|AAB17262.1| 487|Homo sapiens serine/threonine protein ... 180 8e-45
BC093768-1|AAH93768.1| 487|Homo sapiens serine/threonine kinase... 180 8e-45
BC058916-1|AAH58916.1| 405|Homo sapiens STK4 protein protein. 180 8e-45
BC015332-1|AAH15332.1| 405|Homo sapiens Unknown (protein for IM... 180 8e-45
AL109839-4|CAI95634.1| 487|Homo sapiens serine/threonine kinase... 180 8e-45
AL109839-3|CAI95633.1| 462|Homo sapiens serine/threonine kinase... 180 8e-45
BC029511-1|AAH29511.1| 405|Homo sapiens STK4 protein protein. 179 2e-44
AB209315-1|BAD92552.1| 511|Homo sapiens serine/threonine kinase... 177 4e-44
U66840-1|AAB40653.1| 352|Homo sapiens MAP kinase 3c protein. 176 1e-43
U66839-1|AAB40652.1| 347|Homo sapiens MAP kinase 3b protein. 176 1e-43
L36719-1|AAC41718.1| 318|Homo sapiens MAP kinase kinase 3 protein. 176 1e-43
D87116-1|BAA13248.1| 347|Homo sapiens MAP kinase kinase 3b prot... 176 1e-43
CR536514-1|CAG38752.1| 347|Homo sapiens MAP2K3 protein. 176 1e-43
BC032478-1|AAH32478.1| 347|Homo sapiens mitogen-activated prote... 176 1e-43
DQ445915-1|ABE03013.1| 435|Homo sapiens mitogen-activated prote... 175 2e-43
CR541793-1|CAG46592.1| 347|Homo sapiens MAP2K3 protein. 175 2e-43
AF022805-1|AAC26142.1| 419|Homo sapiens c-Jun N-terminal kinase... 175 2e-43
AF013589-1|AAC16273.1| 462|Homo sapiens mitogen-activated prote... 174 4e-43
AF013588-1|AAC16272.1| 419|Homo sapiens mitogen-activated prote... 174 4e-43
U39064-1|AAB03708.1| 278|Homo sapiens MAP kinase kinase 6 protein. 174 5e-43
AK223490-1|BAD97210.1| 347|Homo sapiens mitogen-activated prote... 174 5e-43
AF006689-1|AAB97813.1| 401|Homo sapiens Jnkk2 protein. 174 5e-43
U60206-1|AAB17261.1| 491|Homo sapiens serine/threonine protein ... 173 9e-43
U26424-1|AAC50386.1| 491|Homo sapiens MST2 protein. 173 9e-43
BC010640-1|AAH10640.1| 491|Homo sapiens serine/threonine kinase... 173 9e-43
AF014401-1|AAB88048.1| 419|Homo sapiens JNK kinase 2 protein. 173 9e-43
BC099843-1|AAH99843.1| 416|Homo sapiens serine/threonine protei... 164 6e-40
BT020099-1|AAV38902.1| 416|Homo sapiens Mst3 and SOK1-related k... 163 1e-39
BC103503-1|AAI03504.1| 416|Homo sapiens serine/threonine protei... 163 1e-39
BC098315-1|AAH98315.1| 416|Homo sapiens serine/threonine protei... 163 1e-39
AL109749-1|CAI42079.1| 416|Homo sapiens Mst3 and SOK1-related k... 163 1e-39
AK075150-1|BAC11435.1| 392|Homo sapiens protein ( Homo sapiens ... 163 1e-39
AF344882-1|AAK29620.1| 416|Homo sapiens serine/threonine protei... 163 1e-39
AF231012-1|AAK38484.1| 416|Homo sapiens STE20-like kinase MST4 ... 163 1e-39
AB040057-1|BAA92785.2| 416|Homo sapiens serine/threonine protei... 163 1e-39
BT019619-1|AAV38425.1| 431|Homo sapiens serine/threonine kinase... 159 1e-38
BC065378-1|AAH65378.1| 431|Homo sapiens serine/threonine kinase... 159 1e-38
BC035578-1|AAH35578.1| 431|Homo sapiens serine/threonine kinase... 159 1e-38
AL356423-3|CAI13115.1| 431|Homo sapiens serine/threonine kinase... 159 1e-38
AL356423-2|CAI13114.1| 443|Homo sapiens serine/threonine kinase... 159 1e-38
AL137249-7|CAI39457.1| 431|Homo sapiens serine/threonine kinase... 159 1e-38
AL137249-3|CAI39453.1| 443|Homo sapiens serine/threonine kinase... 159 1e-38
AF083420-1|AAD42039.1| 443|Homo sapiens brain-specific STE20-li... 159 1e-38
AF024636-1|AAB82560.1| 431|Homo sapiens STE20-like kinase 3 pro... 159 1e-38
X99325-1|CAA67700.1| 426|Homo sapiens Ste20-like kinase protein. 158 4e-38
D63780-1|BAA20420.1| 426|Homo sapiens YSK1 protein. 158 4e-38
DQ093965-1|AAY88740.1| 426|Homo sapiens serine/threonine kinase... 158 4e-38
BT019961-1|AAV38764.1| 426|Homo sapiens serine/threonine kinase... 158 4e-38
BC091505-1|AAH91505.1| 426|Homo sapiens STK25 protein protein. 158 4e-38
BC015793-1|AAH15793.1| 426|Homo sapiens STK25 protein protein. 158 4e-38
BC007852-1|AAH07852.1| 426|Homo sapiens serine/threonine kinase... 158 4e-38
AC110299-2|AAY14683.1| 426|Homo sapiens unknown protein. 158 4e-38
CR542227-1|CAG47023.1| 431|Homo sapiens STK24 protein. 157 6e-38
BC070077-1|AAH70077.1| 968|Homo sapiens serine/threonine kinase... 147 7e-35
AB015718-1|BAA35073.1| 968|Homo sapiens protein kinase protein. 146 9e-35
D86959-1|BAA13195.2| 1164|Homo sapiens KIAA0204 protein protein. 138 2e-32
BC111565-1|AAI11566.1| 1204|Homo sapiens SLK protein protein. 138 2e-32
BC064804-1|AAH64804.1| 617|Homo sapiens SLK protein protein. 138 2e-32
BC047885-1|AAH47885.1| 426|Homo sapiens SLK protein protein. 138 2e-32
BC047762-1|AAH47762.1| 614|Homo sapiens SLK protein protein. 138 2e-32
AL360170-2|CAH70404.1| 1235|Homo sapiens Ste20-related serine\/t... 138 2e-32
AL360170-1|CAH70403.1| 1204|Homo sapiens Ste20-related serine\/t... 138 2e-32
AL138761-2|CAI12395.1| 1235|Homo sapiens Ste20-related serine\/t... 138 2e-32
AL138761-1|CAI12396.1| 1204|Homo sapiens Ste20-related serine\/t... 138 2e-32
AF273048-1|AAG34908.1| 1235|Homo sapiens CTCL tumor antigen se20... 138 2e-32
AB002804-1|BAA19655.1| 1204|Homo sapiens hSLK protein. 138 2e-32
U66464-1|AAB97983.1| 833|Homo sapiens hematopoietic progenitor ... 132 2e-30
AL356423-1|CAI13113.1| 368|Homo sapiens serine/threonine kinase... 130 6e-30
AL137249-2|CAI39452.1| 368|Homo sapiens serine/threonine kinase... 130 6e-30
BC041799-1|AAH41799.1| 592|Homo sapiens CDKL3 protein protein. 130 1e-29
AF130372-1|AAF36509.1| 455|Homo sapiens serine-threonine protei... 130 1e-29
AF000145-1|AAC15472.1| 884|Homo sapiens germinal center kinase ... 129 1e-29
BC071579-1|AAH71579.1| 873|Homo sapiens MAP4K3 protein protein. 128 3e-29
AF445413-2|AAN75850.1| 873|Homo sapiens MAP4K3 protein. 128 3e-29
AF445413-1|AAN75849.1| 894|Homo sapiens MAP4K3 protein. 128 3e-29
AC007684-1|AAF19240.1| 712|Homo sapiens unknown protein. 128 3e-29
AF172271-1|AAF03789.1| 1268|Homo sapiens Traf2 and NCK interacti... 127 6e-29
AF172270-1|AAF03788.1| 1297|Homo sapiens Traf2 and NCK interacti... 127 6e-29
AF172269-1|AAF03787.1| 1323|Homo sapiens Traf2 and NCK interacti... 127 6e-29
AF172268-1|AAF03786.1| 1276|Homo sapiens Traf2 and NCK interacti... 127 6e-29
AF172267-1|AAF03785.1| 1352|Homo sapiens Traf2 and NCK interacti... 127 6e-29
AF172266-1|AAF03784.1| 1305|Homo sapiens Traf2 and NCK interacti... 127 6e-29
AF172265-1|AAF03783.1| 1331|Homo sapiens Traf2 and NCK interacti... 127 6e-29
AF172264-1|AAF03782.1| 1360|Homo sapiens Traf2 and NCK interacti... 127 6e-29
AB011123-1|BAA25477.2| 1385|Homo sapiens KIAA0551 protein protein. 127 6e-29
U77129-1|AAB48435.1| 846|Homo sapiens KHS1 protein. 126 1e-28
BC036013-1|AAH36013.1| 846|Homo sapiens mitogen-activated prote... 126 1e-28
AY847283-1|AAW31760.1| 379|Homo sapiens cyclin-dependent kinase... 126 1e-28
AY845084-1|AAW30008.1| 315|Homo sapiens cyclin-dependent kinase... 126 1e-28
AK075107-1|BAC11406.1| 339|Homo sapiens protein ( Homo sapiens ... 126 1e-28
X66358-1|CAA47002.1| 358|Homo sapiens serine/threonine protein ... 125 2e-28
BC104977-1|AAI04978.1| 358|Homo sapiens cyclin-dependent kinase... 125 2e-28
AY525548-1|AAS00095.1| 358|Homo sapiens cyclin-dependent kinase... 125 2e-28
AF344883-1|AAK29621.1| 354|Homo sapiens serine/threonine protei... 125 2e-28
BC034673-1|AAH34673.1| 1332|Homo sapiens misshapen-like kinase 1... 124 6e-28
AY775058-1|AAV41830.1| 1312|Homo sapiens misshapen/NIKs-related ... 124 6e-28
AB041926-1|BAA94838.1| 1303|Homo sapiens GCK family kinase MINK-... 124 6e-28
AB035698-1|BAA90753.1| 1295|Homo sapiens Misshapen/NIK-related k... 124 6e-28
Z92542-3|CAI42485.1| 1030|Homo sapiens cyclin-dependent kinase-l... 122 2e-27
Y15057-1|CAA75342.1| 1030|Homo sapiens STK9 protein protein. 122 2e-27
BC047865-1|AAH47865.1| 812|Homo sapiens MAP4K2 protein protein. 122 2e-27
AY217744-1|AAO64440.1| 1030|Homo sapiens serine/threonine kinase... 122 2e-27
AY212247-1|AAO32626.1| 1239|Homo sapiens Ste20 group protein kin... 122 2e-27
AL109798-1|CAI41159.1| 1030|Homo sapiens cyclin-dependent kinase... 122 2e-27
AF096300-1|AAD16137.1| 1165|Homo sapiens HPK/GCK-like kinase HGK... 122 2e-27
U07349-1|AAA20968.1| 819|Homo sapiens GC kinase protein. 121 5e-27
BC035596-1|AAH35596.1| 681|Homo sapiens PAK6 protein protein. 121 5e-27
AJ236915-1|CAC18720.1| 681|Homo sapiens pak5 protein protein. 121 5e-27
AF276893-1|AAF82800.1| 681|Homo sapiens p21-activated protein k... 121 5e-27
DQ201638-1|ABA27097.1| 527|Homo sapiens oxidative-stress respon... 119 2e-26
BC008726-1|AAH08726.1| 527|Homo sapiens oxidative-stress respon... 119 2e-26
AB017642-1|BAA75674.1| 527|Homo sapiens oxidative-stress respon... 119 2e-26
BC133039-1|AAI33040.1| 1001|Homo sapiens TAO kinase 1 protein. 116 1e-25
BC129951-1|AAI29952.1| 854|Homo sapiens MAP3K6 protein protein. 116 1e-25
BC129950-1|AAI29951.1| 854|Homo sapiens MAP3K6 protein protein. 116 1e-25
BC109032-1|AAI09033.1| 441|Homo sapiens MAP3K6 protein protein. 116 1e-25
BC015914-1|AAH15914.1| 797|Homo sapiens MAP3K6 protein protein. 116 1e-25
AY049015-1|AAL12217.1| 1001|Homo sapiens serine/threonine kinase... 116 1e-25
AL663123-5|CAI14778.1| 797|Homo sapiens mitogen-activated prote... 116 1e-25
AL663123-4|CAM12869.1| 1288|Homo sapiens mitogen-activated prote... 116 1e-25
AF100318-1|AAD05304.1| 1011|Homo sapiens mitogen-activated prote... 116 1e-25
AB208805-1|BAD92042.1| 1192|Homo sapiens mitogen-activated prote... 116 1e-25
AB167411-1|BAD12485.1| 1288|Homo sapiens apoptosis signal-regula... 116 1e-25
AB037782-1|BAA92599.1| 1005|Homo sapiens KIAA1361 protein protein. 116 1e-25
BC026158-1|AAH26158.1| 1315|Homo sapiens serine/threonine kinase... 116 1e-25
BC027464-1|AAH27464.1| 403|Homo sapiens aurora kinase A protein. 115 3e-25
BC006423-1|AAH06423.1| 403|Homo sapiens aurora kinase A protein. 115 3e-25
BC002499-1|AAH02499.1| 403|Homo sapiens AURKA protein protein. 115 3e-25
BC001280-1|AAH01280.1| 403|Homo sapiens aurora kinase A protein. 115 3e-25
AL121914-4|CAM45838.1| 347|Homo sapiens aurora kinase A protein. 115 3e-25
AL121914-3|CAC12717.1| 403|Homo sapiens aurora kinase A protein. 115 3e-25
AF195947-1|AAF29508.1| 403|Homo sapiens STK15 serine/threonine ... 115 3e-25
AF011468-1|AAC63902.1| 403|Homo sapiens serine/threonine kinase... 115 3e-25
AF008551-1|AAC12708.1| 403|Homo sapiens aurora-related kinase 1... 115 3e-25
D84212-1|BAA23592.1| 402|Homo sapiens aurora/IPL1-related kinas... 115 3e-25
M34182-1|AAC41690.1| 360|Homo sapiens protein kinase A gamma-su... 114 5e-25
DQ667175-1|ABG25920.1| 351|Homo sapiens protein kinase, cAMP-de... 114 5e-25
BC125272-1|AAI25273.1| 625|Homo sapiens MYO3A protein protein. 114 5e-25
BC119811-1|AAI19812.1| 664|Homo sapiens MYO3A protein protein. 114 5e-25
BC039888-1|AAH39888.1| 351|Homo sapiens protein kinase, cAMP-de... 114 5e-25
AY101367-1|AAM34500.1| 1616|Homo sapiens myosin IIIA protein. 114 5e-25
AL391812-1|CAI17380.1| 1616|Homo sapiens myosin IIIA protein. 114 5e-25
AL360217-1|CAD13206.2| 1616|Homo sapiens myosin IIIA protein. 114 5e-25
AL358612-1|CAH73814.1| 1616|Homo sapiens myosin IIIA protein. 114 5e-25
AL162730-1|CAH71828.1| 351|Homo sapiens protein kinase, cAMP-de... 114 5e-25
AL162503-4|CAH73661.1| 1616|Homo sapiens myosin IIIA protein. 114 5e-25
AJ001597-1|CAA04863.1| 351|Homo sapiens cAMP-dependent protein ... 114 5e-25
AF229172-1|AAF70861.1| 1615|Homo sapiens class III myosin protein. 114 5e-25
AF200815-1|AAF97028.1| 1315|Homo sapiens FUSED serine/threonine ... 114 6e-25
AB033104-1|BAA86592.1| 1311|Homo sapiens KIAA1278 protein protein. 114 6e-25
AB014587-1|BAA31662.1| 1175|Homo sapiens KIAA0687 protein protein. 114 6e-25
U35146-1|AAC50918.1| 493|Homo sapiens p56 KKIAMRE protein kinas... 113 8e-25
BC093981-1|AAH93981.1| 493|Homo sapiens cyclin-dependent kinase... 113 8e-25
BC093646-1|AAH93646.1| 493|Homo sapiens cyclin-dependent kinase... 113 8e-25
BC024179-1|AAH24179.1| 719|Homo sapiens p21(CDKN1A)-activated k... 113 8e-25
AL353612-1|CAI23529.1| 719|Homo sapiens p21(CDKN1A)-activated k... 113 8e-25
AL135935-1|CAH71126.1| 719|Homo sapiens p21(CDKN1A)-activated k... 113 8e-25
AL031652-1|CAI42211.1| 719|Homo sapiens p21(CDKN1A)-activated k... 113 8e-25
AB040812-1|BAA94194.1| 719|Homo sapiens protein kinase PAK5 pro... 113 8e-25
AB033090-1|BAA86578.1| 753|Homo sapiens KIAA1264 protein protein. 113 8e-25
AF263312-1|AAG38502.1| 1001|Homo sapiens STE20-like kinase protein. 113 1e-24
AF003199-1|AAB63374.1| 260|Homo sapiens MAP kinase kinase 7 pro... 113 1e-24
U24153-1|AAA65442.1| 525|Homo sapiens p21-activated protein kin... 113 1e-24
BC075064-1|AAH75064.2| 275|Homo sapiens AURKC protein protein. 113 1e-24
AY714054-1|AAU04399.1| 306|Homo sapiens aurora-C protein. 113 1e-24
AY661554-1|AAT64422.1| 290|Homo sapiens aurora/Ipl1-related kin... 113 1e-24
AF054621-1|AAC25955.1| 309|Homo sapiens serine/threonine kinase... 113 1e-24
AB017332-1|BAA76292.1| 309|Homo sapiens Aurora/Ipl1-related kin... 113 1e-24
U67156-1|AAC50894.1| 1374|Homo sapiens mitogen-activated kinase ... 112 2e-24
D84476-1|BAA12684.2| 1374|Homo sapiens apoptosis signal-regulati... 112 2e-24
BC088829-1|AAH88829.1| 1374|Homo sapiens mitogen-activated prote... 112 2e-24
BC054503-1|AAH54503.1| 1374|Homo sapiens mitogen-activated prote... 112 2e-24
AL121933-1|CAI15470.1| 1374|Homo sapiens mitogen-activated prote... 112 2e-24
AL024508-2|CAI20176.1| 1374|Homo sapiens mitogen-activated prote... 112 2e-24
AK131359-1|BAD18511.1| 510|Homo sapiens protein ( Homo sapiens ... 112 2e-24
AF059681-1|AAC77369.1| 275|Homo sapiens serine/threonine kinase... 112 2e-24
AB209093-1|BAD92330.1| 1455|Homo sapiens mitogen-activated prote... 112 2e-24
BC019916-1|AAH19916.2| 506|Homo sapiens NIMA (never in mitosis ... 112 2e-24
BC005298-1|AAH05298.1| 346|Homo sapiens cyclin-dependent kinase... 112 2e-24
AL139082-7|CAI12895.1| 507|Homo sapiens NIMA (never in mitosis ... 112 2e-24
Y13120-1|CAA73587.1| 346|Homo sapiens serine/threonine protein ... 111 3e-24
X79193-1|CAA55785.1| 346|Homo sapiens MO15/CDK-activating kinas... 111 3e-24
X77743-1|CAA54793.1| 346|Homo sapiens CDK activating kinase pro... 111 3e-24
X77303-1|CAA54508.1| 346|Homo sapiens Cdk-activating kinase pro... 111 3e-24
L20320-1|AAA36657.1| 346|Homo sapiens protein serine/threonine ... 111 3e-24
BC000834-1|AAH00834.1| 346|Homo sapiens cyclin-dependent kinase... 111 3e-24
AY130859-1|AAM77799.1| 346|Homo sapiens cyclin-dependent kinase... 111 3e-24
Z98049-1|CAI20579.1| 733|Homo sapiens ribosomal protein S6 kina... 111 4e-24
X85106-1|CAA59427.1| 733|Homo sapiens ribosomal S6 kinase protein. 111 4e-24
BC002363-1|AAH02363.1| 733|Homo sapiens ribosomal protein S6 ki... 111 4e-24
AL022069-2|CAI19651.1| 733|Homo sapiens ribosomal protein S6 ki... 111 4e-24
AB209116-1|BAD92353.1| 806|Homo sapiens ribosomal protein S6 ki... 111 4e-24
U78876-1|AAB41729.1| 626|Homo sapiens MEK kinase 3 protein. 111 6e-24
DQ454151-1|ABE11554.1| 622|Homo sapiens mitogen-activated prote... 111 6e-24
BC093674-1|AAH93674.1| 626|Homo sapiens mitogen-activated prote... 111 6e-24
BC093672-1|AAH93672.1| 626|Homo sapiens mitogen-activated prote... 111 6e-24
BC090859-1|AAH90859.1| 626|Homo sapiens mitogen-activated prote... 111 6e-24
BC008336-1|AAH08336.1| 594|Homo sapiens Unknown (protein for IM... 111 6e-24
AB072828-1|BAC15599.1| 489|Homo sapiens NIMA-related protein ki... 110 7e-24
Z29066-1|CAA82309.1| 445|Homo sapiens protein kinase protein. 110 1e-23
U11050-1|AAA19558.1| 445|Homo sapiens NIMA-like protein kinase ... 110 1e-23
L07598-1|AAC82496.1| 540|Homo sapiens ribosomal protein S6 kina... 110 1e-23
BT019729-1|AAV38534.1| 445|Homo sapiens NIMA (never in mitosis ... 110 1e-23
BC052807-1|AAH52807.1| 326|Homo sapiens NEK2 protein protein. 110 1e-23
BC043502-1|AAH43502.2| 445|Homo sapiens NIMA (never in mitosis ... 110 1e-23
AY045701-1|AAK92212.1| 384|Homo sapiens NEK2B protein kinase pr... 110 1e-23
AL356310-2|CAH72901.1| 445|Homo sapiens NIMA (never in mitosis ... 110 1e-23
AK223353-1|BAD97073.1| 445|Homo sapiens NIMA (never in mitosis ... 110 1e-23
BC109299-1|AAI09300.1| 545|Homo sapiens p21/Cdc42/Rac1-activate... 109 1e-23
AF099989-1|AAC72238.1| 547|Homo sapiens Ste-20 related kinase S... 109 1e-23
AC067940-1|AAY24032.1| 363|Homo sapiens unknown protein. 109 1e-23
AB062450-1|BAB85632.1| 302|Homo sapiens NEK7 protein. 109 1e-23
AF030403-1|AAD01901.1| 547|Homo sapiens Ste20-like protein kina... 109 2e-23
U24152-1|AAA65441.1| 545|Homo sapiens p21-activated protein kin... 109 2e-23
BT019534-1|AAV38341.1| 344|Homo sapiens serine/threonine kinase... 109 2e-23
BC080581-1|AAH80581.1| 344|Homo sapiens aurora kinase B protein. 109 2e-23
BC000442-1|AAH00442.3| 344|Homo sapiens aurora kinase B protein. 109 2e-23
AF008552-1|AAC12709.1| 344|Homo sapiens aurora-related kinase 2... 109 2e-23
AB011450-1|BAA32136.1| 344|Homo sapiens aurora and IPL1-like mi... 109 2e-23
AF042838-1|AAC97073.1| 1495|Homo sapiens MEK kinase 1 protein. 108 3e-23
X61622-1|CAA43807.1| 298|Homo sapiens CDK2 protein. 108 4e-23
BT007185-1|AAP35849.1| 898|Homo sapiens STE20-like kinase protein. 108 4e-23
BC034511-1|AAH34511.1| 501|Homo sapiens PAK4 protein protein. 108 4e-23
BC025282-1|AAH25282.1| 591|Homo sapiens p21(CDKN1A)-activated k... 108 4e-23
BC013300-1|AAH13300.2| 371|Homo sapiens AURKB protein protein. 108 4e-23
BC011368-1|AAH11368.1| 591|Homo sapiens p21(CDKN1A)-activated k... 108 4e-23
BC009751-1|AAH09751.1| 344|Homo sapiens aurora kinase B protein. 108 4e-23
BC002921-1|AAH02921.1| 426|Homo sapiens p21(CDKN1A)-activated k... 108 4e-23
BC002756-1|AAH02756.1| 898|Homo sapiens TAO kinase 3 protein. 108 4e-23
AL732423-2|CAM17479.1| 748|Homo sapiens mitogen-activated prote... 108 4e-23
AL732423-1|CAM17478.1| 788|Homo sapiens mitogen-activated prote... 108 4e-23
AL732326-2|CAM23143.1| 788|Homo sapiens mitogen-activated prote... 108 4e-23
AL732326-1|CAM23142.1| 748|Homo sapiens mitogen-activated prote... 108 4e-23
AK131412-1|BAD18559.1| 748|Homo sapiens protein ( Homo sapiens ... 108 4e-23
AJ011855-1|CAA09820.1| 591|Homo sapiens PAK4 protein protein. 108 4e-23
AF181985-1|AAF25817.1| 898|Homo sapiens serine/threonine kinase... 108 4e-23
AF179867-1|AAF14559.1| 898|Homo sapiens STE20-like kinase protein. 108 4e-23
AF135158-1|AAG09131.1| 898|Homo sapiens serine kinase protein. 108 4e-23
AF005046-1|AAD01210.1| 591|Homo sapiens serine/threonine kinase... 108 4e-23
AB032968-1|BAA86456.1| 467|Homo sapiens KIAA1142 protein protein. 108 4e-23
AB020641-1|BAA74857.2| 453|Homo sapiens KIAA0834 protein protein. 108 4e-23
X66364-1|CAA47007.1| 292|Homo sapiens serine/threonine protein ... 107 5e-23
U51120-1|AAC50590.1| 545|Homo sapiens PAK1 protein. 107 5e-23
BT006680-1|AAP35326.1| 292|Homo sapiens cyclin-dependent kinase... 107 5e-23
BC005115-1|AAH05115.1| 292|Homo sapiens cyclin-dependent kinase... 107 5e-23
AY049778-1|AAL15435.1| 292|Homo sapiens cyclin-dependent kinase... 107 5e-23
M68520-1|AAA35667.1| 298|Homo sapiens cdc2-related protein kina... 107 7e-23
L07597-1|AAC82497.1| 735|Homo sapiens ribosomal protein S6 kina... 107 7e-23
BT006821-1|AAP35467.1| 298|Homo sapiens cyclin-dependent kinase... 107 7e-23
BC014966-1|AAH14966.1| 735|Homo sapiens ribosomal protein S6 ki... 107 7e-23
BC003065-1|AAH03065.1| 298|Homo sapiens cyclin-dependent kinase... 107 7e-23
AY574904-1|AAT81413.1| 510|Homo sapiens regulated in COPD kinas... 107 7e-23
AY574902-1|AAT81411.1| 1215|Homo sapiens regulated in COPD kinas... 107 7e-23
AY574901-1|AAT81410.1| 1328|Homo sapiens regulated in COPD kinas... 107 7e-23
AL627313-6|CAI14649.1| 735|Homo sapiens ribosomal protein S6 ki... 107 7e-23
AK055778-1|BAB71011.1| 1113|Homo sapiens protein ( Homo sapiens ... 107 7e-23
AF512553-1|AAM34794.1| 298|Homo sapiens cyclin-dependent kinase... 107 7e-23
AF391558-1|AAO13803.1| 1192|Homo sapiens myosin IIIB variant MYO... 107 7e-23
AF391557-1|AAO13802.1| 1275|Homo sapiens myosin IIIB variant MYO... 107 7e-23
AF391556-1|AAO13801.1| 1314|Homo sapiens myosin IIIB variant MYO... 107 7e-23
AF391555-1|AAO13800.1| 1341|Homo sapiens myosin IIIB variant MYO... 107 7e-23
AF391554-1|AAO13799.1| 1251|Homo sapiens myosin IIIB variant MYO... 107 7e-23
AF369908-1|AAL57233.1| 1278|Homo sapiens myosin IIIB protein. 107 7e-23
AL357774-2|CAI40843.1| 544|Homo sapiens p21 (CDKN1A)-activated ... 107 9e-23
AL357774-1|CAI40844.1| 559|Homo sapiens p21 (CDKN1A)-activated ... 107 9e-23
AL117326-3|CAI43168.1| 559|Homo sapiens p21 (CDKN1A)-activated ... 107 9e-23
AL117326-2|CAI43167.1| 544|Homo sapiens p21 (CDKN1A)-activated ... 107 9e-23
AL031117-6|CAI43157.1| 544|Homo sapiens p21 (CDKN1A)-activated ... 107 9e-23
AL031117-5|CAI43158.1| 559|Homo sapiens p21 (CDKN1A)-activated ... 107 9e-23
AF155651-1|AAF67008.1| 544|Homo sapiens P21-activated kinase 3 ... 107 9e-23
AF071884-1|AAC24716.1| 553|Homo sapiens p21 activated kinase 1B... 107 9e-23
AF068864-1|AAC36097.1| 544|Homo sapiens p21-activated kinase 3 ... 107 9e-23
AB102659-1|BAC81128.1| 559|Homo sapiens p21-activated kinase 3 ... 107 9e-23
AB029024-1|BAA83053.2| 467|Homo sapiens KIAA1101 protein protein. 107 9e-23
X07767-1|CAA30597.1| 351|Homo sapiens protein ( Human mRNA for ... 106 1e-22
DQ667173-1|ABG25918.1| 351|Homo sapiens protein kinase, cAMP-de... 106 1e-22
BC108259-1|AAI08260.1| 351|Homo sapiens protein kinase, cAMP-de... 106 1e-22
BC065932-1|AAH65932.1| 214|Homo sapiens NEK2 protein protein. 106 1e-22
BC063885-1|AAH63885.1| 708|Homo sapiens NIMA (never in mitosis ... 106 1e-22
BC039846-1|AAH39846.1| 351|Homo sapiens protein kinase, cAMP-de... 106 1e-22
AL139082-5|CAI12892.2| 708|Homo sapiens NIMA (never in mitosis ... 106 1e-22
AK075004-1|BAC11348.1| 423|Homo sapiens protein ( Homo sapiens ... 106 1e-22
AF263311-1|AAG38501.1| 898|Homo sapiens STE20-like kinase protein. 106 2e-22
CR457041-1|CAG33322.1| 292|Homo sapiens CDK5 protein. 105 2e-22
BC035058-1|AAH35058.1| 351|Homo sapiens protein kinase, cAMP-de... 105 2e-22
AK131477-1|BAD18622.1| 788|Homo sapiens protein ( Homo sapiens ... 105 2e-22
AB011446-1|BAA82709.1| 343|Homo sapiens Aik2 protein. 105 2e-22
X62071-1|CAA43985.1| 298|Homo sapiens cdk2 protein. 105 3e-22
U25975-1|AAA75468.1| 493|Homo sapiens hPAK65 protein. 105 3e-22
BC069613-1|AAH69613.1| 524|Homo sapiens p21-activated kinase 2 ... 105 3e-22
AF239798-1|AAF63496.1| 619|Homo sapiens protein kinase MEKK2b p... 105 3e-22
AC110926-2|AAY15070.1| 270|Homo sapiens unknown protein. 105 3e-22
AB208963-1|BAD92200.1| 621|Homo sapiens Protein kinase MEKK2b v... 105 3e-22
M34181-1|AAA60170.1| 351|Homo sapiens cAMP-dependent protein ki... 105 4e-22
DQ667174-1|ABG25919.1| 398|Homo sapiens protein kinase, cAMP-de... 105 4e-22
BC016285-1|AAH16285.1| 257|Homo sapiens protein kinase, cAMP-de... 105 4e-22
AL450063-11|CAI16854.1| 264|Homo sapiens protein kinase, cAMP-d... 105 4e-22
AL450063-7|CAI16850.1| 245|Homo sapiens protein kinase, cAMP-de... 105 4e-22
AL450063-3|CAI16846.1| 398|Homo sapiens protein kinase, cAMP-de... 105 4e-22
AL450063-2|CAI16845.1| 351|Homo sapiens protein kinase, cAMP-de... 105 4e-22
AL450063-1|CAI16844.1| 257|Homo sapiens protein kinase, cAMP-de... 105 4e-22
AL359504-2|CAI14541.1| 351|Homo sapiens protein kinase, cAMP-de... 105 4e-22
AL359504-1|CAI14540.1| 257|Homo sapiens protein kinase, cAMP-de... 105 4e-22
AF119833-1|AAG43234.1| 469|Homo sapiens serine/threonine protei... 105 4e-22
AB209189-1|BAD92426.1| 365|Homo sapiens cAMP-dependent protein ... 105 4e-22
AC114794-1|AAY24159.1| 249|Homo sapiens unknown protein. 104 5e-22
AB088047-1|BAC03375.1| 752|Homo sapiens microtubule affinity-re... 104 6e-22
AB049127-1|BAB39380.1| 688|Homo sapiens MAP/microtubule affinit... 104 6e-22
X66357-1|CAA47001.1| 305|Homo sapiens serine/threonine protein ... 103 8e-22
CR542222-1|CAG47018.1| 306|Homo sapiens NEK6 protein. 103 8e-22
BC012761-1|AAH12761.1| 313|Homo sapiens NIMA (never in mitosis ... 103 8e-22
BC004209-1|AAH04209.2| 313|Homo sapiens NEK6 protein protein. 103 8e-22
BC004174-1|AAH04174.2| 313|Homo sapiens NEK6 protein protein. 103 8e-22
BC000101-1|AAH00101.2| 313|Homo sapiens NEK6 protein protein. 103 8e-22
AY789470-1|AAV40830.1| 305|Homo sapiens cyclin-dependent kinase... 103 8e-22
AL389887-1|CAC16111.2| 745|Homo sapiens ribosomal protein S6 ki... 103 8e-22
AL354653-1|CAD13486.2| 745|Homo sapiens ribosomal protein S6 ki... 103 8e-22
AL162724-9|CAH70254.1| 313|Homo sapiens NIMA (never in mitosis ... 103 8e-22
AL162724-2|CAH70247.1| 347|Homo sapiens NIMA (never in mitosis ... 103 8e-22
AL137846-13|CAI10883.1| 313|Homo sapiens NIMA (never in mitosis... 103 8e-22
AL137846-6|CAI10876.1| 347|Homo sapiens NIMA (never in mitosis ... 103 8e-22
AF184965-1|AAF13190.1| 745|Homo sapiens ribosomal S6 kinase pro... 103 8e-22
AF111105-1|AAD28547.1| 618|Homo sapiens mitogen-activated prote... 103 8e-22
AF087909-1|AAG13417.1| 338|Homo sapiens NIMA-related kinase 6 p... 103 8e-22
AB026289-1|BAA85045.1| 306|Homo sapiens protein kinase SID6-151... 103 8e-22
CR536566-1|CAG38803.1| 745|Homo sapiens RPS6KA6 protein. 103 1e-21
AY120867-1|AAM55491.1| 752|Homo sapiens MAP/microtubule affinit... 103 1e-21
AY057448-1|AAL23683.1| 752|Homo sapiens MARK4 serine/threonine ... 103 1e-21
AK075272-1|BAC11510.1| 752|Homo sapiens protein ( Homo sapiens ... 103 1e-21
AF015254-1|AAC98891.1| 347|Homo sapiens serine/threonine kinase... 103 1e-21
AB058763-1|BAB47489.1| 689|Homo sapiens KIAA1860 protein protein. 103 1e-21
Y00272-1|CAA68376.1| 297|Homo sapiens protein ( Human cell cycl... 102 2e-21
X05360-1|CAA28963.1| 297|Homo sapiens protein ( Human CDC2 gene... 102 2e-21
U64205-1|AAC15093.1| 729|Homo sapiens Cdc25C associated protein... 102 2e-21
BT007004-1|AAP35650.1| 297|Homo sapiens cell division cycle 2, ... 102 2e-21
BC107750-1|AAI07751.1| 225|Homo sapiens CDC2 protein protein. 102 2e-21
BC024773-1|AAH24773.1| 729|Homo sapiens MAP/microtubule affinit... 102 2e-21
BC014563-1|AAH14563.1| 297|Homo sapiens cell division cycle 2, ... 102 2e-21
AY574905-1|AAT81414.1| 462|Homo sapiens regulated in COPD kinas... 102 2e-21
AF512554-1|AAM34793.1| 297|Homo sapiens cell division cycle 2, ... 102 2e-21
AF465413-1|AAL69982.1| 753|Homo sapiens MAP/microtubule affinit... 102 2e-21
AF387637-1|AAK82367.1| 744|Homo sapiens Ser/Thr protein kinase ... 102 2e-21
Y15056-1|CAA75341.1| 556|Homo sapiens PkB kinase protein. 102 3e-21
U08316-1|AAA81952.1| 740|Homo sapiens insulin-stimulated protei... 102 3e-21
M95936-1|AAA58364.1| 481|Homo sapiens protein serine/threonine ... 102 3e-21
M77198-1|AAA36585.1| 520|Homo sapiens rac protein kinase-beta p... 102 3e-21
L33881-1|AAB17011.1| 587|Homo sapiens protein kinase C iota pro... 102 3e-21
L18964-1|AAA60171.1| 587|Homo sapiens protein kinase C iota pro... 102 3e-21
L07599-1|AAC82495.1| 580|Homo sapiens ribosomal protein S6 kina... 102 3e-21
CR536517-1|CAG38755.1| 556|Homo sapiens PDPK1 protein. 102 3e-21
BC120994-1|AAI20995.1| 481|Homo sapiens v-akt murine thymoma vi... 102 3e-21
BC114478-1|AAI14479.1| 795|Homo sapiens MARK1 protein protein. 102 3e-21
BC113869-1|AAI13870.1| 795|Homo sapiens MARK1 protein protein. 102 3e-21
BC096302-1|AAH96302.1| 740|Homo sapiens ribosomal protein S6 ki... 102 3e-21
BC096301-1|AAH96301.1| 740|Homo sapiens ribosomal protein S6 ki... 102 3e-21
BC051798-1|AAH51798.1| 1426|Homo sapiens TAOK2 protein protein. 102 3e-21
BC031825-1|AAH31825.1| 560|Homo sapiens TAOK2 protein protein. 102 3e-21
BC022016-1|AAH22016.3| 587|Homo sapiens protein kinase C, iota ... 102 3e-21
BC015204-1|AAH15204.1| 762|Homo sapiens Unknown (protein for IM... 102 3e-21
BC012103-1|AAH12103.1| 556|Homo sapiens 3-phosphoinositide depe... 102 3e-21
AY648038-1|AAT67172.1| 1551|Homo sapiens myotonic dystrophy kina... 102 3e-21
AL807772-3|CAI39687.1| 740|Homo sapiens ribosomal protein S6 ki... 102 3e-21
AL732366-2|CAI40548.1| 740|Homo sapiens ribosomal protein S6 ki... 102 3e-21
AL592406-3|CAH72463.1| 795|Homo sapiens MAP/microtubule affinit... 102 3e-21
AF263313-1|AAG38503.1| 1049|Homo sapiens STE20-like kinase protein. 102 3e-21
AF154845-1|AAF72103.1| 795|Homo sapiens MARK protein. 102 3e-21
AF061943-1|AAD45616.1| 1235|Homo sapiens prostate derived STE20-... 102 3e-21
AF017995-1|AAC51825.1| 556|Homo sapiens 3-phosphoinositide depe... 102 3e-21
AC005591-1|AAC33797.1| 367|Homo sapiens PkB-like protein. 102 3e-21
AB209835-1|BAD93072.1| 492|Homo sapiens 3-phosphoinositide depe... 102 3e-21
AB208933-1|BAD92170.1| 806|Homo sapiens ribosomal protein S6 ki... 102 3e-21
AB020688-1|BAA74904.2| 1064|Homo sapiens KIAA0881 protein protein. 102 3e-21
M80359-1|AAA59991.1| 713|Homo sapiens protein p78 protein. 101 3e-21
M63167-1|AAA36539.1| 480|Homo sapiens rac protein kinase-alpha ... 101 3e-21
CR457091-1|CAG33372.1| 306|Homo sapiens NEK6 protein. 101 3e-21
BC096303-1|AAH96303.1| 740|Homo sapiens ribosomal protein S6 ki... 101 3e-21
BC084538-1|AAH84538.1| 480|Homo sapiens v-akt murine thymoma vi... 101 3e-21
BC000479-1|AAH00479.1| 480|Homo sapiens v-akt murine thymoma vi... 101 3e-21
AF283830-1|AAL55732.1| 480|Homo sapiens AKT1 protein. 101 3e-21
AB102662-1|BAC81131.1| 726|Homo sapiens RPS6KA3 protein. 101 3e-21
BC109097-1|AAI09098.2| 795|Homo sapiens MLCK protein protein. 101 5e-21
AY987010-1|AAX88805.1| 393|Homo sapiens serum/glucocorticoid re... 101 5e-21
AJ785968-1|CAH05056.1| 396|Homo sapiens PDPK2 protein protein. 101 5e-21
AJ247087-1|CAC42766.1| 795|Homo sapiens myosin light chain kina... 101 5e-21
AF004022-1|AAB65786.1| 347|Homo sapiens protein kinase protein. 101 5e-21
BC037303-1|AAH37303.1| 550|Homo sapiens PRKAA1 protein protein. 101 6e-21
AB022017-1|BAA36547.1| 550|Homo sapiens AMP-activated protein k... 101 6e-21
BC033005-1|AAH33005.1| 523|Homo sapiens PCTAIRE protein kinase ... 100 8e-21
X85545-1|CAA59733.1| 358|Homo sapiens protein kinase protein. 100 1e-20
BC041073-1|AAH41073.1| 358|Homo sapiens protein kinase, X-linke... 100 1e-20
AB051552-1|BAB21856.1| 608|Homo sapiens KIAA1765 protein protein. 100 1e-20
Z98752-8|CAI42315.1| 366|Homo sapiens serum/glucocorticoid regu... 99 1e-20
M60725-1|AAA36411.1| 502|Homo sapiens p70 ribosomal S6 kinase a... 99 1e-20
M60724-1|AAA36410.1| 525|Homo sapiens p70 ribosomal S6 kinase a... 99 1e-20
BC053365-1|AAH53365.1| 451|Homo sapiens RPS6KB1 protein protein. 99 1e-20
BC036079-1|AAH36079.1| 247|Homo sapiens MYO3A protein protein. 99 1e-20
AL358612-3|CAH73816.1| 247|Homo sapiens myosin IIIA protein. 99 1e-20
AK222581-1|BAD96301.1| 556|Homo sapiens 3-phosphoinositide depe... 99 1e-20
U43195-1|AAB02814.1| 1354|Homo sapiens Rho-associated, coiled-co... 100 2e-20
Z98752-7|CAC18509.1| 367|Homo sapiens serum/glucocorticoid regu... 99 2e-20
Z98752-5|CAI42312.1| 427|Homo sapiens serum/glucocorticoid regu... 99 2e-20
X66363-1|CAA47006.1| 496|Homo sapiens serine/threonine protein ... 99 2e-20
BT020098-1|AAV38901.1| 367|Homo sapiens serum/glucocorticoid re... 99 2e-20
BT006827-1|AAP35473.1| 496|Homo sapiens PCTAIRE protein kinase ... 99 2e-20
BC065511-1|AAH65511.1| 367|Homo sapiens SGK2 protein protein. 99 2e-20
BC015607-1|AAH15607.1| 496|Homo sapiens PCTAIRE protein kinase ... 99 2e-20
BC014037-1|AAH14037.3| 367|Homo sapiens serum/glucocorticoid re... 99 2e-20
BC009852-1|AAH09852.2| 395|Homo sapiens PCTK1 protein protein. 99 2e-20
BC006190-1|AAH06190.1| 448|Homo sapiens PCTK1 protein protein. 99 2e-20
BC001048-1|AAH01048.1| 496|Homo sapiens PCTAIRE protein kinase ... 99 2e-20
AY353238-1|AAR13066.1| 504|Homo sapiens PCTAIRE protein kinase ... 99 2e-20
AY353237-1|AAR13065.1| 474|Homo sapiens PCTAIRE protein kinase ... 99 2e-20
AL357131-4|CAH72012.1| 472|Homo sapiens PCTAIRE protein kinase ... 99 2e-20
AL096791-1|CAD20055.1| 496|Homo sapiens PCTAIRE protein kinase ... 99 2e-20
AF186470-1|AAG17012.1| 427|Homo sapiens protein kinase protein. 99 2e-20
AF169034-1|AAF12757.2| 367|Homo sapiens protein kinase protein. 99 2e-20
AB209307-1|BAD92544.1| 436|Homo sapiens PCTAIRE protein kinase ... 99 2e-20
X97630-1|CAA66229.1| 745|Homo sapiens serine/threonine protein ... 99 3e-20
X80229-1|CAA56515.1| 479|Homo sapiens serine/threonine protein ... 99 3e-20
X75756-1|CAA53384.1| 912|Homo sapiens protein kinase C mu protein. 99 3e-20
DQ485452-1|ABE96833.1| 914|Homo sapiens protein kinase D1 protein. 99 3e-20
BT007342-1|AAP36006.1| 755|Homo sapiens MAP/microtubule affinit... 99 3e-20
BC084540-1|AAH84540.1| 724|Homo sapiens MAP/microtubule affinit... 99 3e-20
BC008771-1|AAH08771.2| 778|Homo sapiens MARK2 protein protein. 99 3e-20
AF387638-1|AAK82368.1| 691|Homo sapiens Ser/Thr protein kinase ... 99 3e-20
AB188493-1|BAD37141.1| 719|Homo sapiens serine/threonine kinase... 99 3e-20
D87931-1|BAA75636.1| 1388|Homo sapiens Rho kinase protein. 98 4e-20
AB014519-1|BAA31594.2| 1428|Homo sapiens KIAA0619 protein protein. 98 4e-20
Z84486-1|CAI21678.1| 526|Homo sapiens serum/glucocorticoid regu... 98 6e-20
Y10032-1|CAA71138.1| 431|Homo sapiens serine/threonine protein ... 98 6e-20
X66360-1|CAA47004.1| 523|Homo sapiens serine/threonine protein ... 98 6e-20
U33053-1|AAC50209.1| 942|Homo sapiens PRK1 protein. 98 6e-20
S75546-1|AAB33345.1| 942|Homo sapiens protein kinase PRK1 protein. 98 6e-20
D26181-1|BAA05169.1| 942|Homo sapiens PKN protein. 98 6e-20
BC040061-1|AAH40061.1| 942|Homo sapiens protein kinase N1 protein. 98 6e-20
BC001263-1|AAH01263.1| 431|Homo sapiens serum/glucocorticoid re... 98 6e-20
AL355881-2|CAH72579.1| 526|Homo sapiens serum/glucocorticoid re... 98 6e-20
AL135839-4|CAI19721.1| 526|Homo sapiens serum/glucocorticoid re... 98 6e-20
AL135839-3|CAI19720.1| 445|Homo sapiens serum/glucocorticoid re... 98 6e-20
AL135839-2|CAI19719.1| 431|Homo sapiens serum/glucocorticoid re... 98 6e-20
AL135839-1|CAI19718.1| 421|Homo sapiens serum/glucocorticoid re... 98 6e-20
AJ000512-1|CAA04146.1| 431|Homo sapiens serine/threonine protei... 98 6e-20
AF153609-1|AAD41091.1| 431|Homo sapiens serine/threonine protei... 98 6e-20
AB001872-1|BAA24817.1| 966|Homo sapiens leucine zipper bearing ... 98 6e-20
BC113705-1|AAI13706.1| 692|Homo sapiens NIMA (never in mitosis ... 97 7e-20
BC112240-1|AAI12241.1| 692|Homo sapiens NIMA-related kinase 8 p... 97 7e-20
BC032709-1|AAH32709.1| 344|Homo sapiens Unknown (protein for IM... 97 7e-20
BC017306-1|AAH17306.1| 628|Homo sapiens NUAK family, SNF1-like ... 97 7e-20
AY267371-1|AAP04006.1| 692|Homo sapiens NIMA-family kinase NEK8... 97 7e-20
AY242354-1|AAO88243.1| 692|Homo sapiens NIMA-related kinase 12a... 97 7e-20
AY098866-1|AAM21719.1| 486|Homo sapiens PKE protein kinase prot... 97 7e-20
AL590105-1|CAI13011.1| 486|Homo sapiens protein kinase (PKE) pr... 97 7e-20
AL512622-1|CAI12181.1| 486|Homo sapiens protein kinase (PKE) pr... 97 7e-20
AK074830-1|BAC11234.1| 628|Homo sapiens protein ( Homo sapiens ... 97 7e-20
EF056019-1|ABK30810.1| 552|Homo sapiens AMP-activated alpha 2 s... 97 1e-19
BC045538-1|AAH45538.1| 247|Homo sapiens MYO3A protein protein. 97 1e-19
BC020479-1|AAH20479.1| 466|Homo sapiens AKT3 protein protein. 97 1e-19
BC015472-1|AAH15472.1| 363|Homo sapiens PRKD2 protein protein. 97 1e-19
AY005799-1|AAF91073.1| 465|Homo sapiens protein kinase B gamma ... 97 1e-19
AL662889-3|CAH73073.1| 479|Homo sapiens v-akt murine thymoma vi... 97 1e-19
AL662889-2|CAH73072.1| 465|Homo sapiens v-akt murine thymoma vi... 97 1e-19
AL592151-2|CAH72892.1| 479|Homo sapiens v-akt murine thymoma vi... 97 1e-19
AL592151-1|CAH72891.1| 465|Homo sapiens v-akt murine thymoma vi... 97 1e-19
AL591721-2|CAH71867.1| 479|Homo sapiens v-akt murine thymoma vi... 97 1e-19
AL591721-1|CAH71866.1| 465|Homo sapiens v-akt murine thymoma vi... 97 1e-19
AL353572-4|CAM17657.1| 346|Homo sapiens cell cycle related kina... 97 1e-19
AK075266-1|BAC11508.1| 721|Homo sapiens protein ( Homo sapiens ... 97 1e-19
AK074673-1|BAC11127.1| 721|Homo sapiens protein ( Homo sapiens ... 97 1e-19
AJ245709-1|CAB53537.1| 479|Homo sapiens Akt-3 protein protein. 97 1e-19
>L05624-1|AAA36318.1| 393|Homo sapiens MAP kinase kinase protein.
Length = 393
Score = 545 bits (1344), Expect = e-154
Identities = 264/381 (69%), Positives = 311/381 (81%), Gaps = 16/381 (4%)
Query: 30 TP-QLKSATANERQGLAGKSKTSIEALTERLEQIEMDDTQRRRIEVFLCQKEKIGELSDD 88
TP QL A ++T++EAL ++LE++E+D+ QR+R+E FL QK+K+GEL DD
Sbjct: 7 TPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDD 66
Query: 89 DFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHI 148
DFEK+ ELG GNGGVV KV HK +GL+MARKLIHLE+KPAI+ QIIREL+VLHECN +I
Sbjct: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126
Query: 149 VGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
VGFYGAFYSDGEISICME+MDGGSLD +LKKAGRIPE ILG ++ AV+KGL+YLR+KH I
Sbjct: 127 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKI 186
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDI 268
MHRDVKPSNILVNS GEIK+CDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDI
Sbjct: 187 MHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDI 246
Query: 269 WSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNE---------DHSPGQ-----APNSPR 314
WS+GLSLVEMA+G YPIPPPDAK L +FG Q E +PG+ +S
Sbjct: 247 WSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRP 306
Query: 315 PMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEA 374
PMAIFELLDYIVNEPPPKLPSG+FS EF+DFV++CL KNP ERADLK LM H +I++++A
Sbjct: 307 PMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDA 366
Query: 375 EKVDIAGWVCKTMDL-MPSTP 394
E+VD AGW+C T+ L PSTP
Sbjct: 367 EEVDFAGWLCSTIGLNQPSTP 387
>BC139729-1|AAI39730.1| 393|Homo sapiens mitogen-activated protein
kinase kinase 1 protein.
Length = 393
Score = 545 bits (1344), Expect = e-154
Identities = 264/381 (69%), Positives = 311/381 (81%), Gaps = 16/381 (4%)
Query: 30 TP-QLKSATANERQGLAGKSKTSIEALTERLEQIEMDDTQRRRIEVFLCQKEKIGELSDD 88
TP QL A ++T++EAL ++LE++E+D+ QR+R+E FL QK+K+GEL DD
Sbjct: 7 TPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDD 66
Query: 89 DFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHI 148
DFEK+ ELG GNGGVV KV HK +GL+MARKLIHLE+KPAI+ QIIREL+VLHECN +I
Sbjct: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126
Query: 149 VGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
VGFYGAFYSDGEISICME+MDGGSLD +LKKAGRIPE ILG ++ AV+KGL+YLR+KH I
Sbjct: 127 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKI 186
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDI 268
MHRDVKPSNILVNS GEIK+CDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDI
Sbjct: 187 MHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDI 246
Query: 269 WSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNE---------DHSPGQ-----APNSPR 314
WS+GLSLVEMA+G YPIPPPDAK L +FG Q E +PG+ +S
Sbjct: 247 WSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRP 306
Query: 315 PMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEA 374
PMAIFELLDYIVNEPPPKLPSG+FS EF+DFV++CL KNP ERADLK LM H +I++++A
Sbjct: 307 PMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDA 366
Query: 375 EKVDIAGWVCKTMDL-MPSTP 394
E+VD AGW+C T+ L PSTP
Sbjct: 367 EEVDFAGWLCSTIGLNQPSTP 387
>BC018645-1|AAH18645.1| 400|Homo sapiens mitogen-activated protein
kinase kinase 2 protein.
Length = 400
Score = 526 bits (1298), Expect = e-149
Identities = 251/368 (68%), Positives = 302/368 (82%), Gaps = 19/368 (5%)
Query: 46 GKSKTSIEALTERLEQIEMDDTQRRRIEVFLCQKEKIGELSDDDFEKLGELGQGNGGVVM 105
G S+ ++ L ++LE++E+D+ Q++R+E FL QK K+GEL DDDFE++ ELG GNGGVV
Sbjct: 28 GASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVT 87
Query: 106 KVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIVGFYGAFYSDGEISICM 165
KV+H+ +GLIMARKLIHLE+KPAI+ QIIREL+VLHECN +IVGFYGAFYSDGEISICM
Sbjct: 88 KVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICM 147
Query: 166 EYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVKPSNILVNSNGE 225
E+MDGGSLD +LK+A RIPE ILG ++ AVL+GL+YLR+KH IMHRDVKPSNILVNS GE
Sbjct: 148 EHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGE 207
Query: 226 IKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPI 285
IK+CDFGVSGQLIDSMANSFVGTRSYM+PERLQGTHYSVQSDIWS+GLSLVE+A+G YPI
Sbjct: 208 IKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPI 267
Query: 286 PPPDAKTLAAIFGG------QNEDHSPGQAPNSP-----------RP-MAIFELLDYIVN 327
PPPDAK L AIFG + E HS P P RP MAIFELLDYIVN
Sbjct: 268 PPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVN 327
Query: 328 EPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVDIAGWVCKTM 387
EPPPKLP+G+F+ +F++FV++CL KNP ERADLK L NH +I+++E E+VD AGW+CKT+
Sbjct: 328 EPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGWLCKTL 387
Query: 388 DL-MPSTP 394
L P TP
Sbjct: 388 RLNQPGTP 395
>BC000471-1|AAH00471.1| 400|Homo sapiens mitogen-activated protein
kinase kinase 2 protein.
Length = 400
Score = 526 bits (1298), Expect = e-149
Identities = 251/368 (68%), Positives = 302/368 (82%), Gaps = 19/368 (5%)
Query: 46 GKSKTSIEALTERLEQIEMDDTQRRRIEVFLCQKEKIGELSDDDFEKLGELGQGNGGVVM 105
G S+ ++ L ++LE++E+D+ Q++R+E FL QK K+GEL DDDFE++ ELG GNGGVV
Sbjct: 28 GASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVT 87
Query: 106 KVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIVGFYGAFYSDGEISICM 165
KV+H+ +GLIMARKLIHLE+KPAI+ QIIREL+VLHECN +IVGFYGAFYSDGEISICM
Sbjct: 88 KVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICM 147
Query: 166 EYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVKPSNILVNSNGE 225
E+MDGGSLD +LK+A RIPE ILG ++ AVL+GL+YLR+KH IMHRDVKPSNILVNS GE
Sbjct: 148 EHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGE 207
Query: 226 IKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPI 285
IK+CDFGVSGQLIDSMANSFVGTRSYM+PERLQGTHYSVQSDIWS+GLSLVE+A+G YPI
Sbjct: 208 IKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPI 267
Query: 286 PPPDAKTLAAIFGG------QNEDHSPGQAPNSP-----------RP-MAIFELLDYIVN 327
PPPDAK L AIFG + E HS P P RP MAIFELLDYIVN
Sbjct: 268 PPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVN 327
Query: 328 EPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVDIAGWVCKTM 387
EPPPKLP+G+F+ +F++FV++CL KNP ERADLK L NH +I+++E E+VD AGW+CKT+
Sbjct: 328 EPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGWLCKTL 387
Query: 388 DL-MPSTP 394
L P TP
Sbjct: 388 RLNQPGTP 395
>BC067760-1|AAH67760.1| 380|Homo sapiens LOC407835 protein protein.
Length = 380
Score = 471 bits (1161), Expect = e-132
Identities = 232/353 (65%), Positives = 281/353 (79%), Gaps = 19/353 (5%)
Query: 46 GKSKTSIEALTERLEQIEMDDTQRRRIEVFLCQKEKIGELSDDDFEKLGELGQGNGGVVM 105
G S+ ++ L ++LE++E+D+ Q++R+E FL QK K+GEL DDDFE+ EL GNGGVV
Sbjct: 28 GASEANLVDLQKKLEELELDE-QQKRLEAFLTQKAKVGELKDDDFERTSELDAGNGGVVT 86
Query: 106 KVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIVGFYGAFYSDGEISICM 165
KV+H+ +GLIMARKLIHLE+KPAI+ QIIRE +VLHECN +IVGFYGAFY D EISICM
Sbjct: 87 KVQHRPSGLIMARKLIHLEIKPAIRNQIIREHQVLHECNSPYIVGFYGAFYCDREISICM 146
Query: 166 EYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVKPSNILVNSNGE 225
E+MDGGSLD LK+A RIPE ILG ++ AVL+GL+YLR+KH IMHR+VKPSNILVNS GE
Sbjct: 147 EHMDGGSLDQGLKEAKRIPEDILGKVSIAVLRGLAYLREKHQIMHRNVKPSNILVNSRGE 206
Query: 226 IKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPI 285
IK+CDFGVSGQLIDSMANSF+GTRSYM+PERLQGTHYSVQS IWS+ LSLVE+AI YPI
Sbjct: 207 IKLCDFGVSGQLIDSMANSFMGTRSYMAPERLQGTHYSVQSVIWSMDLSLVELAIERYPI 266
Query: 286 PPPDAKTLAAIFG------GQNEDHSPGQAPNSP-RP-----------MAIFELLDYIVN 327
PPPDAK L AIFG + E HS P SP RP MAIFELLDYIV
Sbjct: 267 PPPDAKELEAIFGQPVVDREEGEPHSISSWPGSPGRPNSGYGMDSLPAMAIFELLDYIVK 326
Query: 328 EPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVDIA 380
EPPPKLP+G+F+ +F++FV++CL KNP ERADLK L NH +I+++E ++ D A
Sbjct: 327 EPPPKLPNGVFTPDFQEFVNKCLIKNPTERADLKMLTNHAFIKRSEVKEADFA 379
>BX538081-1|CAD98005.1| 303|Homo sapiens hypothetical protein
protein.
Length = 303
Score = 440 bits (1085), Expect = e-123
Identities = 214/298 (71%), Positives = 246/298 (82%), Gaps = 19/298 (6%)
Query: 116 MARKLIHLEVKPAIKKQIIRELKVLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSLDL 175
MARKLIHLE+KPAI+ QIIREL+VLHECN +IVGFYGAFYSDGEISICME+MDGGSLD
Sbjct: 1 MARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQ 60
Query: 176 ILKKAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSG 235
+LK+A RIPE ILG ++ AVL+GL+YLR+KH IMHRDVKPSNILVNS GEIK+CDFGVSG
Sbjct: 61 VLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSG 120
Query: 236 QLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAA 295
QLIDSMANSFVGTRSYM+PERLQGTHYSVQSDIWS+GLSLVE+A+G YPIPPPDAK L A
Sbjct: 121 QLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEA 180
Query: 296 IFGG------QNEDHSPGQAPNSP-----------RP-MAIFELLDYIVNEPPPKLPSGI 337
IFG + E HS P P RP MAIFELLDYIVNEPPPKLP+G+
Sbjct: 181 IFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGV 240
Query: 338 FSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVDIAGWVCKTMDL-MPSTP 394
FS +F++FV++CL KNP ERADLK L NH +I+++E E+VD AGW+CKT+ L P TP
Sbjct: 241 FSPDFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTP 298
>U71087-1|AAB16851.1| 448|Homo sapiens MAP kinase kinase MEK5b
protein.
Length = 448
Score = 256 bits (626), Expect = 1e-67
Identities = 128/307 (41%), Positives = 195/307 (63%), Gaps = 27/307 (8%)
Query: 83 GELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE 142
G++++ D LG GNGG V K H +G I+A K+I L++ ++KQI+ EL++L++
Sbjct: 159 GQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYK 218
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYL 202
C+ ++I+GFYGAF+ + ISIC E+MDGGSLD+ K +PE +LG I AV+KGL+YL
Sbjct: 219 CDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRK----MPEHVLGRIAVAVVKGLTYL 274
Query: 203 RDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY 262
I+HRDVKPSN+LVN+ G++K+CDFGVS QL++S+A ++VGT +YM+PER+ G Y
Sbjct: 275 WSLK-ILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQY 333
Query: 263 SVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELL 322
+ SD+WSLG+S +E+A+G +P P Q + + +LL
Sbjct: 334 GIHSDVWSLGISFMELALGRFPYP---------------------QIQKNQGSLMPLQLL 372
Query: 323 DYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI-RKAEAEKVDIAG 381
IV+E P LP G FS+ F F+ +C++K P ER + LM H +I + + ++
Sbjct: 373 QCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNAAVVSM 432
Query: 382 WVCKTMD 388
WVC+ ++
Sbjct: 433 WVCRALE 439
>CR542229-1|CAG47025.1| 448|Homo sapiens MAP2K5 protein.
Length = 448
Score = 256 bits (626), Expect = 1e-67
Identities = 128/307 (41%), Positives = 195/307 (63%), Gaps = 27/307 (8%)
Query: 83 GELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE 142
G++++ D LG GNGG V K H +G I+A K+I L++ ++KQI+ EL++L++
Sbjct: 159 GQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYK 218
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYL 202
C+ ++I+GFYGAF+ + ISIC E+MDGGSLD+ K +PE +LG I AV+KGL+YL
Sbjct: 219 CDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRK----MPEHVLGRIAVAVVKGLTYL 274
Query: 203 RDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY 262
I+HRDVKPSN+LVN+ G++K+CDFGVS QL++S+A ++VGT +YM+PER+ G Y
Sbjct: 275 WSLK-ILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQY 333
Query: 263 SVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELL 322
+ SD+WSLG+S +E+A+G +P P Q + + +LL
Sbjct: 334 GIHSDVWSLGISFMELALGRFPYP---------------------QIQKNQGSLMPLQLL 372
Query: 323 DYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI-RKAEAEKVDIAG 381
IV+E P LP G FS+ F F+ +C++K P ER + LM H +I + + ++
Sbjct: 373 QCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNAAVVSM 432
Query: 382 WVCKTMD 388
WVC+ ++
Sbjct: 433 WVCRALE 439
>BT006780-1|AAP35426.1| 448|Homo sapiens mitogen-activated protein
kinase kinase 5 protein.
Length = 448
Score = 256 bits (626), Expect = 1e-67
Identities = 128/307 (41%), Positives = 195/307 (63%), Gaps = 27/307 (8%)
Query: 83 GELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE 142
G++++ D LG GNGG V K H +G I+A K+I L++ ++KQI+ EL++L++
Sbjct: 159 GQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYK 218
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYL 202
C+ ++I+GFYGAF+ + ISIC E+MDGGSLD+ K +PE +LG I AV+KGL+YL
Sbjct: 219 CDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRK----MPEHVLGRIAVAVVKGLTYL 274
Query: 203 RDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY 262
I+HRDVKPSN+LVN+ G++K+CDFGVS QL++S+A ++VGT +YM+PER+ G Y
Sbjct: 275 WSLK-ILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQY 333
Query: 263 SVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELL 322
+ SD+WSLG+S +E+A+G +P P Q + + +LL
Sbjct: 334 GIHSDVWSLGISFMELALGRFPYP---------------------QIQKNQGSLMPLQLL 372
Query: 323 DYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI-RKAEAEKVDIAG 381
IV+E P LP G FS+ F F+ +C++K P ER + LM H +I + + ++
Sbjct: 373 QCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNAAVVSM 432
Query: 382 WVCKTMD 388
WVC+ ++
Sbjct: 433 WVCRALE 439
>BC008838-1|AAH08838.1| 448|Homo sapiens mitogen-activated protein
kinase kinase 5 protein.
Length = 448
Score = 256 bits (626), Expect = 1e-67
Identities = 128/307 (41%), Positives = 195/307 (63%), Gaps = 27/307 (8%)
Query: 83 GELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE 142
G++++ D LG GNGG V K H +G I+A K+I L++ ++KQI+ EL++L++
Sbjct: 159 GQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYK 218
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYL 202
C+ ++I+GFYGAF+ + ISIC E+MDGGSLD+ K +PE +LG I AV+KGL+YL
Sbjct: 219 CDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRK----MPEHVLGRIAVAVVKGLTYL 274
Query: 203 RDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY 262
I+HRDVKPSN+LVN+ G++K+CDFGVS QL++S+A ++VGT +YM+PER+ G Y
Sbjct: 275 WSLK-ILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQY 333
Query: 263 SVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELL 322
+ SD+WSLG+S +E+A+G +P P Q + + +LL
Sbjct: 334 GIHSDVWSLGISFMELALGRFPYP---------------------QIQKNQGSLMPLQLL 372
Query: 323 DYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI-RKAEAEKVDIAG 381
IV+E P LP G FS+ F F+ +C++K P ER + LM H +I + + ++
Sbjct: 373 QCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNAAVVSM 432
Query: 382 WVCKTMD 388
WVC+ ++
Sbjct: 433 WVCRALE 439
>U71088-1|AAB16852.2| 444|Homo sapiens MAP kinase kinase MEK5c
protein.
Length = 444
Score = 216 bits (528), Expect = 1e-55
Identities = 98/196 (50%), Positives = 145/196 (73%), Gaps = 5/196 (2%)
Query: 83 GELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE 142
G++++ D LG GNGG V K H +G I+A K+I L++ ++KQI+ EL++L++
Sbjct: 159 GQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYK 218
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYL 202
C+ ++I+GFYGAF+ + ISIC E+MDGGSLD+ K +PE +LG I AV+KGL+YL
Sbjct: 219 CDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRK----MPEHVLGRIAVAVVKGLTYL 274
Query: 203 RDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY 262
I+HRDVKPSN+LVN+ G++K+CDFGVS QL++S+A ++VGT +YM+PER+ G Y
Sbjct: 275 WSLK-ILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQY 333
Query: 263 SVQSDIWSLGLSLVEM 278
+ SD+WSLG+S +E+
Sbjct: 334 GIHSDVWSLGISFMEI 349
Score = 53.6 bits (123), Expect = 1e-06
Identities = 25/70 (35%), Positives = 41/70 (58%), Gaps = 1/70 (1%)
Query: 320 ELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI-RKAEAEKVD 378
+LL IV+E P LP G FS+ F F+ +C++K P ER + LM H +I + +
Sbjct: 360 QLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNAAV 419
Query: 379 IAGWVCKTMD 388
++ WVC+ ++
Sbjct: 420 VSMWVCRALE 429
>U25265-1|AAA96146.1| 438|Homo sapiens MEK5 protein.
Length = 438
Score = 216 bits (528), Expect = 1e-55
Identities = 98/196 (50%), Positives = 145/196 (73%), Gaps = 5/196 (2%)
Query: 83 GELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE 142
G++++ D LG GNGG V K H +G I+A K+I L++ ++KQI+ EL++L++
Sbjct: 159 GQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYK 218
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYL 202
C+ ++I+GFYGAF+ + ISIC E+MDGGSLD+ K +PE +LG I AV+KGL+YL
Sbjct: 219 CDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRK----MPEHVLGRIAVAVVKGLTYL 274
Query: 203 RDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY 262
I+HRDVKPSN+LVN+ G++K+CDFGVS QL++S+A ++VGT +YM+PER+ G Y
Sbjct: 275 WSLK-ILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQY 333
Query: 263 SVQSDIWSLGLSLVEM 278
+ SD+WSLG+S +E+
Sbjct: 334 GIHSDVWSLGISFMEI 349
Score = 53.6 bits (123), Expect = 1e-06
Identities = 25/70 (35%), Positives = 41/70 (58%), Gaps = 1/70 (1%)
Query: 320 ELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI-RKAEAEKVD 378
+LL IV+E P LP G FS+ F F+ +C++K P ER + LM H +I + +
Sbjct: 360 QLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNAAV 419
Query: 379 IAGWVCKTMD 388
++ WVC+ ++
Sbjct: 420 VSMWVCRALE 429
>BC038295-1|AAH38295.1| 426|Homo sapiens MAP2K7 protein protein.
Length = 426
Score = 194 bits (473), Expect = 5e-49
Identities = 119/321 (37%), Positives = 176/321 (54%), Gaps = 32/321 (9%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVL---HECN 144
+D E LGE+G G G V K+R + TG ++A K + K+I+ +L V+ H+C
Sbjct: 118 NDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCP 177
Query: 145 FAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRD 204
+ IV +G F ++ ++ I ME M + L + G IPE ILG +T A++K L YL++
Sbjct: 178 Y--IVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKE 235
Query: 205 KHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANS-FVGTRSYMSPERLQGTH-- 261
KH ++HRDVKPSNIL++ G+IK+CDFG+SG+L+DS A + G +YM+PER+
Sbjct: 236 KHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPT 295
Query: 262 ---YSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAI 318
Y +++D+WSLG+SL P P P LA GQ P
Sbjct: 296 KPDYDIRADVWSLGISL--------PCPSPSQVELAT-----------GQFPYK-NCKTD 335
Query: 319 FELLDYIVNEPPPKLPSGI-FSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKV 377
FE+L ++ E PP LP + FS +F+ FV CL K+ +R L+ H +I++ E +V
Sbjct: 336 FEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEV 395
Query: 378 DIAGWVCKTMDLMPSTPNSNV 398
D+A W M S S V
Sbjct: 396 DVASWFKDVMAKTESPRTSGV 416
>U17743-1|AAC50127.1| 399|Homo sapiens JNK activating kinase
protein.
Length = 399
Score = 194 bits (472), Expect = 6e-49
Identities = 127/330 (38%), Positives = 185/330 (56%), Gaps = 40/330 (12%)
Query: 80 EKIGELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKV 139
E+ + + +D + LGE+G+G G V K+ HK +G IMA K I V +KQ++ +L V
Sbjct: 92 EQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDV 151
Query: 140 -LHECNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGR-----IPESILGTITS 193
+ + +IV FYGA + +G+ ICME M S D K IPE ILG IT
Sbjct: 152 VMRSSDCPYIVQFYGALFREGDCWICMELMST-SFDKFYKYVYSVLDDVIPEEILGKITL 210
Query: 194 AVLKGLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANS-FVGTRSYM 252
A +K L++L++ I+HRD+KPSNIL++ +G IK+CDFG+SGQL+DS+A + G R YM
Sbjct: 211 ATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYM 270
Query: 253 SPERLQGT----HYSVQSDIWSLGLSLVEMAIGMYPIPPPDA--KTLAAIFGGQNEDHSP 306
+PER+ + Y V+SD+WSLG++L E+A G +P P ++ L + G P
Sbjct: 271 APERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKG-----DP 325
Query: 307 GQAPNSPRPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNH 366
Q NS E PS I +FV+ CL K+ +R K L+ H
Sbjct: 326 PQLSNS---------------EEREFSPSFI------NFVNLCLTKDESKRPKYKELLKH 364
Query: 367 EWIRKAEAEKVDIAGWVCKTMDLMPSTPNS 396
+I E V++A +VCK +D MP+TP+S
Sbjct: 365 PFILMYEERAVEVACYVCKILDQMPATPSS 394
>L36870-1|AAC41719.1| 399|Homo sapiens MAP kinase kinase 4 protein.
Length = 399
Score = 194 bits (472), Expect = 6e-49
Identities = 127/330 (38%), Positives = 185/330 (56%), Gaps = 40/330 (12%)
Query: 80 EKIGELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKV 139
E+ + + +D + LGE+G+G G V K+ HK +G IMA K I V +KQ++ +L V
Sbjct: 92 EQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDV 151
Query: 140 -LHECNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGR-----IPESILGTITS 193
+ + +IV FYGA + +G+ ICME M S D K IPE ILG IT
Sbjct: 152 VMRSSDCPYIVQFYGALFREGDCWICMELMST-SFDKFYKYVYSVLDDVIPEEILGKITL 210
Query: 194 AVLKGLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANS-FVGTRSYM 252
A +K L++L++ I+HRD+KPSNIL++ +G IK+CDFG+SGQL+DS+A + G R YM
Sbjct: 211 ATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYM 270
Query: 253 SPERLQGT----HYSVQSDIWSLGLSLVEMAIGMYPIPPPDA--KTLAAIFGGQNEDHSP 306
+PER+ + Y V+SD+WSLG++L E+A G +P P ++ L + G P
Sbjct: 271 APERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKG-----DP 325
Query: 307 GQAPNSPRPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNH 366
Q NS E PS I +FV+ CL K+ +R K L+ H
Sbjct: 326 PQLSNS---------------EEREFSPSFI------NFVNLCLTKDESKRPKYKELLKH 364
Query: 367 EWIRKAEAEKVDIAGWVCKTMDLMPSTPNS 396
+I E V++A +VCK +D MP+TP+S
Sbjct: 365 PFILMYEERAVEVACYVCKILDQMPATPSS 394
>DQ015703-1|AAY22176.1| 399|Homo sapiens mitogen-activated protein
kinase kinase 4 protein.
Length = 399
Score = 194 bits (472), Expect = 6e-49
Identities = 127/330 (38%), Positives = 185/330 (56%), Gaps = 40/330 (12%)
Query: 80 EKIGELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKV 139
E+ + + +D + LGE+G+G G V K+ HK +G IMA K I V +KQ++ +L V
Sbjct: 92 EQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDV 151
Query: 140 -LHECNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGR-----IPESILGTITS 193
+ + +IV FYGA + +G+ ICME M S D K IPE ILG IT
Sbjct: 152 VMRSSDCPYIVQFYGALFREGDCWICMELMST-SFDKFYKYVYSVLDDVIPEEILGKITL 210
Query: 194 AVLKGLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANS-FVGTRSYM 252
A +K L++L++ I+HRD+KPSNIL++ +G IK+CDFG+SGQL+DS+A + G R YM
Sbjct: 211 ATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYM 270
Query: 253 SPERLQGT----HYSVQSDIWSLGLSLVEMAIGMYPIPPPDA--KTLAAIFGGQNEDHSP 306
+PER+ + Y V+SD+WSLG++L E+A G +P P ++ L + G P
Sbjct: 271 APERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKG-----DP 325
Query: 307 GQAPNSPRPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNH 366
Q NS E PS I +FV+ CL K+ +R K L+ H
Sbjct: 326 PQLSNS---------------EEREFSPSFI------NFVNLCLTKDESKRPKYKELLKH 364
Query: 367 EWIRKAEAEKVDIAGWVCKTMDLMPSTPNS 396
+I E V++A +VCK +D MP+TP+S
Sbjct: 365 PFILMYEERAVEVACYVCKILDQMPATPSS 394
>BT019676-1|AAV38482.1| 399|Homo sapiens mitogen-activated protein
kinase kinase 4 protein.
Length = 399
Score = 194 bits (472), Expect = 6e-49
Identities = 127/330 (38%), Positives = 185/330 (56%), Gaps = 40/330 (12%)
Query: 80 EKIGELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKV 139
E+ + + +D + LGE+G+G G V K+ HK +G IMA K I V +KQ++ +L V
Sbjct: 92 EQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDV 151
Query: 140 -LHECNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGR-----IPESILGTITS 193
+ + +IV FYGA + +G+ ICME M S D K IPE ILG IT
Sbjct: 152 VMRSSDCPYIVQFYGALFREGDCWICMELMST-SFDKFYKYVYSVLDDVIPEEILGKITL 210
Query: 194 AVLKGLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANS-FVGTRSYM 252
A +K L++L++ I+HRD+KPSNIL++ +G IK+CDFG+SGQL+DS+A + G R YM
Sbjct: 211 ATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYM 270
Query: 253 SPERLQGT----HYSVQSDIWSLGLSLVEMAIGMYPIPPPDA--KTLAAIFGGQNEDHSP 306
+PER+ + Y V+SD+WSLG++L E+A G +P P ++ L + G P
Sbjct: 271 APERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKG-----DP 325
Query: 307 GQAPNSPRPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNH 366
Q NS E PS I +FV+ CL K+ +R K L+ H
Sbjct: 326 PQLSNS---------------EEREFSPSFI------NFVNLCLTKDESKRPKYKELLKH 364
Query: 367 EWIRKAEAEKVDIAGWVCKTMDLMPSTPNS 396
+I E V++A +VCK +D MP+TP+S
Sbjct: 365 PFILMYEERAVEVACYVCKILDQMPATPSS 394
>BC060764-1|AAH60764.1| 399|Homo sapiens mitogen-activated protein
kinase kinase 4 protein.
Length = 399
Score = 194 bits (472), Expect = 6e-49
Identities = 127/330 (38%), Positives = 185/330 (56%), Gaps = 40/330 (12%)
Query: 80 EKIGELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKV 139
E+ + + +D + LGE+G+G G V K+ HK +G IMA K I V +KQ++ +L V
Sbjct: 92 EQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDV 151
Query: 140 -LHECNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGR-----IPESILGTITS 193
+ + +IV FYGA + +G+ ICME M S D K IPE ILG IT
Sbjct: 152 VMRSSDCPYIVQFYGALFREGDCWICMELMST-SFDKFYKYVYSVLDDVIPEEILGKITL 210
Query: 194 AVLKGLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANS-FVGTRSYM 252
A +K L++L++ I+HRD+KPSNIL++ +G IK+CDFG+SGQL+DS+A + G R YM
Sbjct: 211 ATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYM 270
Query: 253 SPERLQGT----HYSVQSDIWSLGLSLVEMAIGMYPIPPPDA--KTLAAIFGGQNEDHSP 306
+PER+ + Y V+SD+WSLG++L E+A G +P P ++ L + G P
Sbjct: 271 APERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKG-----DP 325
Query: 307 GQAPNSPRPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNH 366
Q NS E PS I +FV+ CL K+ +R K L+ H
Sbjct: 326 PQLSNS---------------EEREFSPSFI------NFVNLCLTKDESKRLKYKELLKH 364
Query: 367 EWIRKAEAEKVDIAGWVCKTMDLMPSTPNS 396
+I E V++A +VCK +D MP+TP+S
Sbjct: 365 PFILMYEERAVEVACYVCKILDQMPATPSS 394
>BC036032-1|AAH36032.1| 399|Homo sapiens mitogen-activated protein
kinase kinase 4 protein.
Length = 399
Score = 194 bits (472), Expect = 6e-49
Identities = 127/330 (38%), Positives = 185/330 (56%), Gaps = 40/330 (12%)
Query: 80 EKIGELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKV 139
E+ + + +D + LGE+G+G G V K+ HK +G IMA K I V +KQ++ +L V
Sbjct: 92 EQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDV 151
Query: 140 -LHECNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGR-----IPESILGTITS 193
+ + +IV FYGA + +G+ ICME M S D K IPE ILG IT
Sbjct: 152 VMRSSDCPYIVQFYGALFREGDCWICMELMST-SFDKFYKYVYSVLDDVIPEEILGKITL 210
Query: 194 AVLKGLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANS-FVGTRSYM 252
A +K L++L++ I+HRD+KPSNIL++ +G IK+CDFG+SGQL+DS+A + G R YM
Sbjct: 211 ATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYM 270
Query: 253 SPERLQGT----HYSVQSDIWSLGLSLVEMAIGMYPIPPPDA--KTLAAIFGGQNEDHSP 306
+PER+ + Y V+SD+WSLG++L E+A G +P P ++ L + G P
Sbjct: 271 APERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKG-----DP 325
Query: 307 GQAPNSPRPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNH 366
Q NS E PS I +FV+ CL K+ +R K L+ H
Sbjct: 326 PQLSNS---------------EEREFSPSFI------NFVNLCLTKDESKRPKYKELLKH 364
Query: 367 EWIRKAEAEKVDIAGWVCKTMDLMPSTPNS 396
+I E V++A +VCK +D MP+TP+S
Sbjct: 365 PFILMYEERAVEVACYVCKILDQMPATPSS 394
>AF070090-1|AAC24130.1| 399|Homo sapiens mitogen-activated protein
kinase kinase 1 protein.
Length = 399
Score = 194 bits (472), Expect = 6e-49
Identities = 127/330 (38%), Positives = 185/330 (56%), Gaps = 40/330 (12%)
Query: 80 EKIGELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKV 139
E+ + + +D + LGE+G+G G V K+ HK +G IMA K I V +KQ++ +L V
Sbjct: 92 EQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDV 151
Query: 140 -LHECNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGR-----IPESILGTITS 193
+ + +IV FYGA + +G+ ICME M S D K IPE ILG IT
Sbjct: 152 VMRSSDCPYIVQFYGALFREGDCWICMELMST-SFDKFYKYVYSVLDDVIPEEILGKITL 210
Query: 194 AVLKGLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANS-FVGTRSYM 252
A +K L++L++ I+HRD+KPSNIL++ +G IK+CDFG+SGQL+DS+A + G R YM
Sbjct: 211 ATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYM 270
Query: 253 SPERLQGT----HYSVQSDIWSLGLSLVEMAIGMYPIPPPDA--KTLAAIFGGQNEDHSP 306
+PER+ + Y V+SD+WSLG++L E+A G +P P ++ L + G P
Sbjct: 271 APERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKG-----DP 325
Query: 307 GQAPNSPRPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNH 366
Q NS E PS I +FV+ CL K+ +R K L+ H
Sbjct: 326 PQLSNS---------------EEREFSPSFI------NFVNLCLTKDESKRPKYKELLKH 364
Query: 367 EWIRKAEAEKVDIAGWVCKTMDLMPSTPNS 396
+I E V++A +VCK +D MP+TP+S
Sbjct: 365 PFILMYEERAVEVACYVCKILDQMPATPSS 394
>CR536564-1|CAG38801.1| 399|Homo sapiens MAP2K4 protein.
Length = 399
Score = 192 bits (469), Expect = 1e-48
Identities = 126/330 (38%), Positives = 185/330 (56%), Gaps = 40/330 (12%)
Query: 80 EKIGELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKV 139
E+ + + +D + LGE+G+G G V ++ HK +G IMA K I V +KQ++ +L V
Sbjct: 92 EQHWDFTAEDLKDLGEIGRGAYGSVNRMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDV 151
Query: 140 -LHECNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGR-----IPESILGTITS 193
+ + +IV FYGA + +G+ ICME M S D K IPE ILG IT
Sbjct: 152 VMRSSDCPYIVQFYGALFREGDCWICMELMST-SFDKFYKYVYSVLDDVIPEEILGKITL 210
Query: 194 AVLKGLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANS-FVGTRSYM 252
A +K L++L++ I+HRD+KPSNIL++ +G IK+CDFG+SGQL+DS+A + G R YM
Sbjct: 211 ATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYM 270
Query: 253 SPERLQGT----HYSVQSDIWSLGLSLVEMAIGMYPIPPPDA--KTLAAIFGGQNEDHSP 306
+PER+ + Y V+SD+WSLG++L E+A G +P P ++ L + G P
Sbjct: 271 APERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKG-----DP 325
Query: 307 GQAPNSPRPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNH 366
Q NS E PS I +FV+ CL K+ +R K L+ H
Sbjct: 326 PQLSNS---------------EEREFSPSFI------NFVNLCLTKDESKRPKYKELLKH 364
Query: 367 EWIRKAEAEKVDIAGWVCKTMDLMPSTPNS 396
+I E V++A +VCK +D MP+TP+S
Sbjct: 365 PFILMYEERAVEVACYVCKILDQMPATPSS 394
>X96757-1|CAA65532.1| 334|Homo sapiens MAP kinase kinase protein.
Length = 334
Score = 184 bits (449), Expect = 4e-46
Identities = 122/350 (34%), Positives = 183/350 (52%), Gaps = 32/350 (9%)
Query: 42 QGLAGKSKTSIEALTERLEQIEMDDTQRRRIEVFLCQK--EKIGELSDDDFEKLGELGQG 99
Q K ++ E EQ + T R ++ C + E+ DD E + ELG+G
Sbjct: 3 QSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRG 62
Query: 100 NGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKV-LHECNFAHIVGFYGAFYSD 158
GVV K+RH +G IMA K I V +K+++ +L + + + V FYGA + +
Sbjct: 63 AYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFRE 122
Query: 159 GEISICMEYMDGGSLDLILK----KAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVK 214
G++ ICME MD SLD K K IPE ILG I +++K L +L K +++HRDVK
Sbjct: 123 GDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVK 181
Query: 215 PSNILVNSNGEIKICDFGVSGQLIDSMANSF-VGTRSYMSPERLQGTHYSVQSDIWSLGL 273
PSN+L+N+ G++K+CDFG+SG L+DS+A + G + YM+PER+ + +S+
Sbjct: 182 PSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINP---ELNQKGYSVKS 238
Query: 274 SLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIVNEPPPKL 333
+ + I M + AI P + +P F+ L +V EP P+L
Sbjct: 239 DIWSLGITMIEL---------AIL------RFPYDSWGTP-----FQQLKQVVEEPSPQL 278
Query: 334 PSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVDIAGWV 383
P+ FS EF DF +CLKKN ER LM H + E++ D+A +V
Sbjct: 279 PADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFV 328
>U49732-1|AAB05035.1| 334|Homo sapiens MAP kinase kinase MEK6
protein.
Length = 334
Score = 184 bits (449), Expect = 4e-46
Identities = 122/350 (34%), Positives = 183/350 (52%), Gaps = 32/350 (9%)
Query: 42 QGLAGKSKTSIEALTERLEQIEMDDTQRRRIEVFLCQK--EKIGELSDDDFEKLGELGQG 99
Q K ++ E EQ + T R ++ C + E+ DD E + ELG+G
Sbjct: 3 QSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRG 62
Query: 100 NGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKV-LHECNFAHIVGFYGAFYSD 158
GVV K+RH +G IMA K I V +K+++ +L + + + V FYGA + +
Sbjct: 63 AYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFRE 122
Query: 159 GEISICMEYMDGGSLDLILK----KAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVK 214
G++ ICME MD SLD K K IPE ILG I +++K L +L K +++HRDVK
Sbjct: 123 GDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVK 181
Query: 215 PSNILVNSNGEIKICDFGVSGQLIDSMANSF-VGTRSYMSPERLQGTHYSVQSDIWSLGL 273
PSN+L+N+ G++K+CDFG+SG L+DS+A + G + YM+PER+ + +S+
Sbjct: 182 PSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINP---ELNQKGYSVKS 238
Query: 274 SLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIVNEPPPKL 333
+ + I M + AI P + +P F+ L +V EP P+L
Sbjct: 239 DIWSLGITMIEL---------AIL------RFPYDSWGTP-----FQQLKQVVEEPSPQL 278
Query: 334 PSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVDIAGWV 383
P+ FS EF DF +CLKKN ER LM H + E++ D+A +V
Sbjct: 279 PADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFV 328
>U39657-1|AAC50389.1| 334|Homo sapiens MAP kinase kinase 6 protein.
Length = 334
Score = 184 bits (449), Expect = 4e-46
Identities = 122/350 (34%), Positives = 183/350 (52%), Gaps = 32/350 (9%)
Query: 42 QGLAGKSKTSIEALTERLEQIEMDDTQRRRIEVFLCQK--EKIGELSDDDFEKLGELGQG 99
Q K ++ E EQ + T R ++ C + E+ DD E + ELG+G
Sbjct: 3 QSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRG 62
Query: 100 NGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKV-LHECNFAHIVGFYGAFYSD 158
GVV K+RH +G IMA K I V +K+++ +L + + + V FYGA + +
Sbjct: 63 AYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFRE 122
Query: 159 GEISICMEYMDGGSLDLILK----KAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVK 214
G++ ICME MD SLD K K IPE ILG I +++K L +L K +++HRDVK
Sbjct: 123 GDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVK 181
Query: 215 PSNILVNSNGEIKICDFGVSGQLIDSMANSF-VGTRSYMSPERLQGTHYSVQSDIWSLGL 273
PSN+L+N+ G++K+CDFG+SG L+DS+A + G + YM+PER+ + +S+
Sbjct: 182 PSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINP---ELNQKGYSVKS 238
Query: 274 SLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIVNEPPPKL 333
+ + I M + AI P + +P F+ L +V EP P+L
Sbjct: 239 DIWSLGITMIEL---------AIL------RFPYDSWGTP-----FQQLKQVVEEPSPQL 278
Query: 334 PSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVDIAGWV 383
P+ FS EF DF +CLKKN ER LM H + E++ D+A +V
Sbjct: 279 PADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFV 328
>U39656-1|AAC50388.1| 334|Homo sapiens MAP kinase kinase 6 protein.
Length = 334
Score = 184 bits (449), Expect = 4e-46
Identities = 122/350 (34%), Positives = 183/350 (52%), Gaps = 32/350 (9%)
Query: 42 QGLAGKSKTSIEALTERLEQIEMDDTQRRRIEVFLCQK--EKIGELSDDDFEKLGELGQG 99
Q K ++ E EQ + T R ++ C + E+ DD E + ELG+G
Sbjct: 3 QSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRG 62
Query: 100 NGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKV-LHECNFAHIVGFYGAFYSD 158
GVV K+RH +G IMA K I V +K+++ +L + + + V FYGA + +
Sbjct: 63 AYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFRE 122
Query: 159 GEISICMEYMDGGSLDLILK----KAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVK 214
G++ ICME MD SLD K K IPE ILG I +++K L +L K +++HRDVK
Sbjct: 123 GDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVK 181
Query: 215 PSNILVNSNGEIKICDFGVSGQLIDSMANSF-VGTRSYMSPERLQGTHYSVQSDIWSLGL 273
PSN+L+N+ G++K+CDFG+SG L+DS+A + G + YM+PER+ + +S+
Sbjct: 182 PSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINP---ELNQKGYSVKS 238
Query: 274 SLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIVNEPPPKL 333
+ + I M + AI P + +P F+ L +V EP P+L
Sbjct: 239 DIWSLGITMIEL---------AIL------RFPYDSWGTP-----FQQLKQVVEEPSPQL 278
Query: 334 PSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVDIAGWV 383
P+ FS EF DF +CLKKN ER LM H + E++ D+A +V
Sbjct: 279 PADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFV 328
>D87905-1|BAA13496.1| 334|Homo sapiens mitogen-activated protein 6
protein.
Length = 334
Score = 184 bits (449), Expect = 4e-46
Identities = 122/350 (34%), Positives = 183/350 (52%), Gaps = 32/350 (9%)
Query: 42 QGLAGKSKTSIEALTERLEQIEMDDTQRRRIEVFLCQK--EKIGELSDDDFEKLGELGQG 99
Q K ++ E EQ + T R ++ C + E+ DD E + ELG+G
Sbjct: 3 QSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRG 62
Query: 100 NGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKV-LHECNFAHIVGFYGAFYSD 158
GVV K+RH +G IMA K I V +K+++ +L + + + V FYGA + +
Sbjct: 63 AYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFRE 122
Query: 159 GEISICMEYMDGGSLDLILK----KAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVK 214
G++ ICME MD SLD K K IPE ILG I +++K L +L K +++HRDVK
Sbjct: 123 GDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVK 181
Query: 215 PSNILVNSNGEIKICDFGVSGQLIDSMANSF-VGTRSYMSPERLQGTHYSVQSDIWSLGL 273
PSN+L+N+ G++K+CDFG+SG L+DS+A + G + YM+PER+ + +S+
Sbjct: 182 PSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINP---ELNQKGYSVKS 238
Query: 274 SLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIVNEPPPKL 333
+ + I M + AI P + +P F+ L +V EP P+L
Sbjct: 239 DIWSLGITMIEL---------AIL------RFPYDSWGTP-----FQQLKQVVEEPSPQL 278
Query: 334 PSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVDIAGWV 383
P+ FS EF DF +CLKKN ER LM H + E++ D+A +V
Sbjct: 279 PADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFV 328
>BC012009-1|AAH12009.1| 334|Homo sapiens mitogen-activated protein
kinase kinase 6 protein.
Length = 334
Score = 184 bits (449), Expect = 4e-46
Identities = 122/350 (34%), Positives = 183/350 (52%), Gaps = 32/350 (9%)
Query: 42 QGLAGKSKTSIEALTERLEQIEMDDTQRRRIEVFLCQK--EKIGELSDDDFEKLGELGQG 99
Q K ++ E EQ + T R ++ C + E+ DD E + ELG+G
Sbjct: 3 QSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRG 62
Query: 100 NGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKV-LHECNFAHIVGFYGAFYSD 158
GVV K+RH +G IMA K I V +K+++ +L + + + V FYGA + +
Sbjct: 63 AYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFRE 122
Query: 159 GEISICMEYMDGGSLDLILK----KAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVK 214
G++ ICME MD SLD K K IPE ILG I +++K L +L K +++HRDVK
Sbjct: 123 GDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVK 181
Query: 215 PSNILVNSNGEIKICDFGVSGQLIDSMANSF-VGTRSYMSPERLQGTHYSVQSDIWSLGL 273
PSN+L+N+ G++K+CDFG+SG L+DS+A + G + YM+PER+ + +S+
Sbjct: 182 PSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINP---ELNQKGYSVKS 238
Query: 274 SLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIVNEPPPKL 333
+ + I M + AI P + +P F+ L +V EP P+L
Sbjct: 239 DIWSLGITMIEL---------AIL------RFPYDSWGTP-----FQQLKQVVEEPSPQL 278
Query: 334 PSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVDIAGWV 383
P+ FS EF DF +CLKKN ER LM H + E++ D+A +V
Sbjct: 279 PADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFV 328
>U39065-1|AAB03705.1| 334|Homo sapiens MAP kinase kinase 6b
protein.
Length = 334
Score = 184 bits (447), Expect = 7e-46
Identities = 122/350 (34%), Positives = 183/350 (52%), Gaps = 32/350 (9%)
Query: 42 QGLAGKSKTSIEALTERLEQIEMDDTQRRRIEVFLCQK--EKIGELSDDDFEKLGELGQG 99
Q K ++ E EQ + T R ++ C + E+ DD E + ELG+G
Sbjct: 3 QSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRG 62
Query: 100 NGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKV-LHECNFAHIVGFYGAFYSD 158
GVV K+RH +G IMA K I V +K+++ +L + + + V FYGA + +
Sbjct: 63 AYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFRE 122
Query: 159 GEISICMEYMDGGSLDLILK----KAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVK 214
G++ ICME MD SLD K K IPE ILG I +++K L +L K +++HRDVK
Sbjct: 123 GDMWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVK 181
Query: 215 PSNILVNSNGEIKICDFGVSGQLIDSMANSF-VGTRSYMSPERLQGTHYSVQSDIWSLGL 273
PSN+L+N+ G++K+CDFG+SG L+DS+A + G + YM+PER+ + +S+
Sbjct: 182 PSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINP---ELNQKGYSVKS 238
Query: 274 SLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIVNEPPPKL 333
+ + I M + AI P + +P F+ L +V EP P+L
Sbjct: 239 DIWSLGITMIEL---------AIL------RFPYDSWGTP-----FQQLKQVVEEPSPQL 278
Query: 334 PSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVDIAGWV 383
P+ FS EF DF +CLKKN ER LM H + E++ D+A +V
Sbjct: 279 PADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFV 328
>U18297-1|AAA83254.1| 487|Homo sapiens MST1 protein.
Length = 487
Score = 180 bits (439), Expect = 6e-45
Identities = 108/322 (33%), Positives = 181/322 (56%), Gaps = 36/322 (11%)
Query: 59 LEQIEMDDTQRRRIEVFLCQKEKIGELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMAR 118
+E +++ + RR+++ ++ + + ++ F+ L +LG+G+ G V K HK TG I+A
Sbjct: 1 METVQLRNPPRRQLKKL--DEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAI 58
Query: 119 KLIHLEVKPAIKKQIIRELKVLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSL-DLIL 177
K + +E + ++II+E+ ++ +C+ H+V +YG+++ + ++ I MEY GS+ D+I
Sbjct: 59 KQVPVE---SDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIR 115
Query: 178 KKAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQL 237
+ + E + TI + LKGL YL I HRD+K NIL+N+ G K+ DFGV+GQL
Sbjct: 116 LRNKTLTEDEIATILQSTLKGLEYLHFMRKI-HRDIKAGNILLNTEGHAKLADFGVAGQL 174
Query: 238 IDSMA--NSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAA 295
D+MA N+ +GT +M+PE +Q Y+ +DIWSLG++ +EMA G P D + A
Sbjct: 175 TDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKRPY--ADIHPMRA 232
Query: 296 IFGGQNEDHSPGQAPNSPRPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPD 355
IF P +P PP ++SD F DFV +CL K+P+
Sbjct: 233 IF----------MIPTNP---------------PPTFRKPELWSDNFTDFVKQCLVKSPE 267
Query: 356 ERADLKTLMNHEWIRKAEAEKV 377
+RA L+ H ++R A+ +
Sbjct: 268 QRATATQLLQHPFVRSAKGVSI 289
>Z93016-2|CAI19815.1| 487|Homo sapiens serine/threonine kinase 4
protein.
Length = 487
Score = 180 bits (438), Expect = 8e-45
Identities = 108/322 (33%), Positives = 181/322 (56%), Gaps = 36/322 (11%)
Query: 59 LEQIEMDDTQRRRIEVFLCQKEKIGELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMAR 118
+E +++ + RR+++ ++ + + ++ F+ L +LG+G+ G V K HK TG I+A
Sbjct: 1 METVQLRNPPRRQLKKL--DEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAI 58
Query: 119 KLIHLEVKPAIKKQIIRELKVLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSL-DLIL 177
K + +E + ++II+E+ ++ +C+ H+V +YG+++ + ++ I MEY GS+ D+I
Sbjct: 59 KQVPVE---SDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIR 115
Query: 178 KKAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQL 237
+ + E + TI + LKGL YL I HRD+K NIL+N+ G K+ DFGV+GQL
Sbjct: 116 LRNKTLTEDEIATILQSTLKGLEYLHFMRKI-HRDIKAGNILLNTEGHAKLADFGVAGQL 174
Query: 238 IDSMA--NSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAA 295
D+MA N+ +GT +M+PE +Q Y+ +DIWSLG++ +EMA G P D + A
Sbjct: 175 TDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPY--ADIHPMRA 232
Query: 296 IFGGQNEDHSPGQAPNSPRPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPD 355
IF P +P PP ++SD F DFV +CL K+P+
Sbjct: 233 IF----------MIPTNP---------------PPTFRKPELWSDNFTDFVKQCLVKSPE 267
Query: 356 ERADLKTLMNHEWIRKAEAEKV 377
+RA L+ H ++R A+ +
Sbjct: 268 QRATATQLLQHPFVRSAKGVSI 289
>Z93016-1|CAB07508.2| 462|Homo sapiens serine/threonine kinase 4
protein.
Length = 462
Score = 180 bits (438), Expect = 8e-45
Identities = 108/322 (33%), Positives = 181/322 (56%), Gaps = 36/322 (11%)
Query: 59 LEQIEMDDTQRRRIEVFLCQKEKIGELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMAR 118
+E +++ + RR+++ ++ + + ++ F+ L +LG+G+ G V K HK TG I+A
Sbjct: 1 METVQLRNPPRRQLKKL--DEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAI 58
Query: 119 KLIHLEVKPAIKKQIIRELKVLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSL-DLIL 177
K + +E + ++II+E+ ++ +C+ H+V +YG+++ + ++ I MEY GS+ D+I
Sbjct: 59 KQVPVE---SDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIR 115
Query: 178 KKAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQL 237
+ + E + TI + LKGL YL I HRD+K NIL+N+ G K+ DFGV+GQL
Sbjct: 116 LRNKTLTEDEIATILQSTLKGLEYLHFMRKI-HRDIKAGNILLNTEGHAKLADFGVAGQL 174
Query: 238 IDSMA--NSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAA 295
D+MA N+ +GT +M+PE +Q Y+ +DIWSLG++ +EMA G P D + A
Sbjct: 175 TDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPY--ADIHPMRA 232
Query: 296 IFGGQNEDHSPGQAPNSPRPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPD 355
IF P +P PP ++SD F DFV +CL K+P+
Sbjct: 233 IF----------MIPTNP---------------PPTFRKPELWSDNFTDFVKQCLVKSPE 267
Query: 356 ERADLKTLMNHEWIRKAEAEKV 377
+RA L+ H ++R A+ +
Sbjct: 268 QRATATQLLQHPFVRSAKGVSI 289
>U60207-1|AAB17262.1| 487|Homo sapiens serine/threonine protein
kinase Krs-2 protein.
Length = 487
Score = 180 bits (438), Expect = 8e-45
Identities = 108/322 (33%), Positives = 181/322 (56%), Gaps = 36/322 (11%)
Query: 59 LEQIEMDDTQRRRIEVFLCQKEKIGELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMAR 118
+E +++ + RR+++ ++ + + ++ F+ L +LG+G+ G V K HK TG I+A
Sbjct: 1 METVQLRNPPRRQLKKL--DEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAI 58
Query: 119 KLIHLEVKPAIKKQIIRELKVLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSL-DLIL 177
K + +E + ++II+E+ ++ +C+ H+V +YG+++ + ++ I MEY GS+ D+I
Sbjct: 59 KQVPVE---SDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIR 115
Query: 178 KKAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQL 237
+ + E + TI + LKGL YL I HRD+K NIL+N+ G K+ DFGV+GQL
Sbjct: 116 LRNKTLTEDEIATILQSTLKGLEYLHFMRKI-HRDIKAGNILLNTEGHAKLADFGVAGQL 174
Query: 238 IDSMA--NSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAA 295
D+MA N+ +GT +M+PE +Q Y+ +DIWSLG++ +EMA G P D + A
Sbjct: 175 TDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPY--ADIHPMRA 232
Query: 296 IFGGQNEDHSPGQAPNSPRPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPD 355
IF P +P PP ++SD F DFV +CL K+P+
Sbjct: 233 IF----------MIPTNP---------------PPTFRKPELWSDNFTDFVKQCLVKSPE 267
Query: 356 ERADLKTLMNHEWIRKAEAEKV 377
+RA L+ H ++R A+ +
Sbjct: 268 QRATATQLLQHPFVRSAKGVSI 289
>BC093768-1|AAH93768.1| 487|Homo sapiens serine/threonine kinase 4
protein.
Length = 487
Score = 180 bits (438), Expect = 8e-45
Identities = 108/322 (33%), Positives = 181/322 (56%), Gaps = 36/322 (11%)
Query: 59 LEQIEMDDTQRRRIEVFLCQKEKIGELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMAR 118
+E +++ + RR+++ ++ + + ++ F+ L +LG+G+ G V K HK TG I+A
Sbjct: 1 METVQLRNPPRRQLKKL--DEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAI 58
Query: 119 KLIHLEVKPAIKKQIIRELKVLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSL-DLIL 177
K + +E + ++II+E+ ++ +C+ H+V +YG+++ + ++ I MEY GS+ D+I
Sbjct: 59 KQVPVE---SDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIR 115
Query: 178 KKAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQL 237
+ + E + TI + LKGL YL I HRD+K NIL+N+ G K+ DFGV+GQL
Sbjct: 116 LRNKTLTEDEIATILQSTLKGLEYLHFMRKI-HRDIKAGNILLNTEGHAKLADFGVAGQL 174
Query: 238 IDSMA--NSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAA 295
D+MA N+ +GT +M+PE +Q Y+ +DIWSLG++ +EMA G P D + A
Sbjct: 175 TDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPY--ADIHPMRA 232
Query: 296 IFGGQNEDHSPGQAPNSPRPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPD 355
IF P +P PP ++SD F DFV +CL K+P+
Sbjct: 233 IF----------MIPTNP---------------PPTFRKPELWSDNFTDFVKQCLVKSPE 267
Query: 356 ERADLKTLMNHEWIRKAEAEKV 377
+RA L+ H ++R A+ +
Sbjct: 268 QRATATQLLQHPFVRSAKGVSI 289
>BC058916-1|AAH58916.1| 405|Homo sapiens STK4 protein protein.
Length = 405
Score = 180 bits (438), Expect = 8e-45
Identities = 108/322 (33%), Positives = 181/322 (56%), Gaps = 36/322 (11%)
Query: 59 LEQIEMDDTQRRRIEVFLCQKEKIGELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMAR 118
+E +++ + RR+++ ++ + + ++ F+ L +LG+G+ G V K HK TG I+A
Sbjct: 1 METVQLRNPPRRQLKKL--DEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAI 58
Query: 119 KLIHLEVKPAIKKQIIRELKVLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSL-DLIL 177
K + +E + ++II+E+ ++ +C+ H+V +YG+++ + ++ I MEY GS+ D+I
Sbjct: 59 KQVPVE---SDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIR 115
Query: 178 KKAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQL 237
+ + E + TI + LKGL YL I HRD+K NIL+N+ G K+ DFGV+GQL
Sbjct: 116 LRNKTLTEDEIATILQSTLKGLEYLHFMRKI-HRDIKAGNILLNTEGHAKLADFGVAGQL 174
Query: 238 IDSMA--NSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAA 295
D+MA N+ +GT +M+PE +Q Y+ +DIWSLG++ +EMA G P D + A
Sbjct: 175 TDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPY--ADIHPMRA 232
Query: 296 IFGGQNEDHSPGQAPNSPRPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPD 355
IF P +P PP ++SD F DFV +CL K+P+
Sbjct: 233 IF----------MIPTNP---------------PPTFRKPELWSDNFTDFVKQCLVKSPE 267
Query: 356 ERADLKTLMNHEWIRKAEAEKV 377
+RA L+ H ++R A+ +
Sbjct: 268 QRATATQLLQHPFVRSAKGVSI 289
>BC015332-1|AAH15332.1| 405|Homo sapiens Unknown (protein for
IMAGE:4400771) protein.
Length = 405
Score = 180 bits (438), Expect = 8e-45
Identities = 108/322 (33%), Positives = 181/322 (56%), Gaps = 36/322 (11%)
Query: 59 LEQIEMDDTQRRRIEVFLCQKEKIGELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMAR 118
+E +++ + RR+++ ++ + + ++ F+ L +LG+G+ G V K HK TG I+A
Sbjct: 1 METVQLRNPPRRQLKKL--DEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAI 58
Query: 119 KLIHLEVKPAIKKQIIRELKVLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSL-DLIL 177
K + +E + ++II+E+ ++ +C+ H+V +YG+++ + ++ I MEY GS+ D+I
Sbjct: 59 KQVPVE---SDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIR 115
Query: 178 KKAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQL 237
+ + E + TI + LKGL YL I HRD+K NIL+N+ G K+ DFGV+GQL
Sbjct: 116 LRNKTLTEDEIATILQSTLKGLEYLHFMRKI-HRDIKAGNILLNTEGHAKLADFGVAGQL 174
Query: 238 IDSMA--NSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAA 295
D+MA N+ +GT +M+PE +Q Y+ +DIWSLG++ +EMA G P D + A
Sbjct: 175 TDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPY--ADIHPMRA 232
Query: 296 IFGGQNEDHSPGQAPNSPRPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPD 355
IF P +P PP ++SD F DFV +CL K+P+
Sbjct: 233 IF----------MIPTNP---------------PPTFRKPELWSDNFTDFVKQCLVKSPE 267
Query: 356 ERADLKTLMNHEWIRKAEAEKV 377
+RA L+ H ++R A+ +
Sbjct: 268 QRATATQLLQHPFVRSAKGVSI 289
>AL109839-4|CAI95634.1| 487|Homo sapiens serine/threonine kinase 4
protein.
Length = 487
Score = 180 bits (438), Expect = 8e-45
Identities = 108/322 (33%), Positives = 181/322 (56%), Gaps = 36/322 (11%)
Query: 59 LEQIEMDDTQRRRIEVFLCQKEKIGELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMAR 118
+E +++ + RR+++ ++ + + ++ F+ L +LG+G+ G V K HK TG I+A
Sbjct: 1 METVQLRNPPRRQLKKL--DEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAI 58
Query: 119 KLIHLEVKPAIKKQIIRELKVLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSL-DLIL 177
K + +E + ++II+E+ ++ +C+ H+V +YG+++ + ++ I MEY GS+ D+I
Sbjct: 59 KQVPVE---SDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIR 115
Query: 178 KKAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQL 237
+ + E + TI + LKGL YL I HRD+K NIL+N+ G K+ DFGV+GQL
Sbjct: 116 LRNKTLTEDEIATILQSTLKGLEYLHFMRKI-HRDIKAGNILLNTEGHAKLADFGVAGQL 174
Query: 238 IDSMA--NSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAA 295
D+MA N+ +GT +M+PE +Q Y+ +DIWSLG++ +EMA G P D + A
Sbjct: 175 TDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPY--ADIHPMRA 232
Query: 296 IFGGQNEDHSPGQAPNSPRPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPD 355
IF P +P PP ++SD F DFV +CL K+P+
Sbjct: 233 IF----------MIPTNP---------------PPTFRKPELWSDNFTDFVKQCLVKSPE 267
Query: 356 ERADLKTLMNHEWIRKAEAEKV 377
+RA L+ H ++R A+ +
Sbjct: 268 QRATATQLLQHPFVRSAKGVSI 289
>AL109839-3|CAI95633.1| 462|Homo sapiens serine/threonine kinase 4
protein.
Length = 462
Score = 180 bits (438), Expect = 8e-45
Identities = 108/322 (33%), Positives = 181/322 (56%), Gaps = 36/322 (11%)
Query: 59 LEQIEMDDTQRRRIEVFLCQKEKIGELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMAR 118
+E +++ + RR+++ ++ + + ++ F+ L +LG+G+ G V K HK TG I+A
Sbjct: 1 METVQLRNPPRRQLKKL--DEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAI 58
Query: 119 KLIHLEVKPAIKKQIIRELKVLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSL-DLIL 177
K + +E + ++II+E+ ++ +C+ H+V +YG+++ + ++ I MEY GS+ D+I
Sbjct: 59 KQVPVE---SDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIR 115
Query: 178 KKAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQL 237
+ + E + TI + LKGL YL I HRD+K NIL+N+ G K+ DFGV+GQL
Sbjct: 116 LRNKTLTEDEIATILQSTLKGLEYLHFMRKI-HRDIKAGNILLNTEGHAKLADFGVAGQL 174
Query: 238 IDSMA--NSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAA 295
D+MA N+ +GT +M+PE +Q Y+ +DIWSLG++ +EMA G P D + A
Sbjct: 175 TDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPY--ADIHPMRA 232
Query: 296 IFGGQNEDHSPGQAPNSPRPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPD 355
IF P +P PP ++SD F DFV +CL K+P+
Sbjct: 233 IF----------MIPTNP---------------PPTFRKPELWSDNFTDFVKQCLVKSPE 267
Query: 356 ERADLKTLMNHEWIRKAEAEKV 377
+RA L+ H ++R A+ +
Sbjct: 268 QRATATQLLQHPFVRSAKGVSI 289
>BC029511-1|AAH29511.1| 405|Homo sapiens STK4 protein protein.
Length = 405
Score = 179 bits (435), Expect = 2e-44
Identities = 108/322 (33%), Positives = 180/322 (55%), Gaps = 36/322 (11%)
Query: 59 LEQIEMDDTQRRRIEVFLCQKEKIGELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMAR 118
+E +++ + RR+++ ++ + + ++ F+ L +LG+G+ G V K HK TG I+A
Sbjct: 1 METVQLRNPPRRQLKKL--DEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAI 58
Query: 119 KLIHLEVKPAIKKQIIRELKVLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSL-DLIL 177
K + +E + ++II+E+ ++ +C+ H+V +YG+++ + ++ I MEY GS+ D+I
Sbjct: 59 KQVPVE---SDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIR 115
Query: 178 KKAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQL 237
+ + E + TI + LKGL YL I HRD+K NIL+N+ G K+ DFGV+GQL
Sbjct: 116 LRNKTLTEDEIATILQSTLKGLEYLHFMRKI-HRDIKAGNILLNTEGHAKLADFGVAGQL 174
Query: 238 IDSMA--NSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAA 295
D+MA N+ +GT M+PE +Q Y+ +DIWSLG++ +EMA G P D + A
Sbjct: 175 TDTMAKRNTVIGTPFLMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPY--ADIHPMRA 232
Query: 296 IFGGQNEDHSPGQAPNSPRPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPD 355
IF P +P PP ++SD F DFV +CL K+P+
Sbjct: 233 IF----------MIPTNP---------------PPTFRKPELWSDNFTDFVKQCLVKSPE 267
Query: 356 ERADLKTLMNHEWIRKAEAEKV 377
+RA L+ H ++R A+ +
Sbjct: 268 QRATATQLLQHPFVRSAKGVSI 289
>AB209315-1|BAD92552.1| 511|Homo sapiens serine/threonine kinase 4
variant protein.
Length = 511
Score = 177 bits (432), Expect = 4e-44
Identities = 107/320 (33%), Positives = 180/320 (56%), Gaps = 36/320 (11%)
Query: 61 QIEMDDTQRRRIEVFLCQKEKIGELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKL 120
++++ + RR+++ ++ + + ++ F+ L +LG+G+ G V K HK TG I+A K
Sbjct: 27 RLQLRNPPRRQLKKL--DEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQ 84
Query: 121 IHLEVKPAIKKQIIRELKVLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSL-DLILKK 179
+ +E + ++II+E+ ++ +C+ H+V +YG+++ + ++ I MEY GS+ D+I +
Sbjct: 85 VPVE---SDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLR 141
Query: 180 AGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLID 239
+ E + TI + LKGL YL I HRD+K NIL+N+ G K+ DFGV+GQL D
Sbjct: 142 NKTLTEDEIATILQSTLKGLEYLHFMRKI-HRDIKAGNILLNTEGHAKLADFGVAGQLTD 200
Query: 240 SMA--NSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIF 297
+MA N+ +GT +M+PE +Q Y+ +DIWSLG++ +EMA G P D + AIF
Sbjct: 201 TMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPY--ADIHPMRAIF 258
Query: 298 GGQNEDHSPGQAPNSPRPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDER 357
P +P PP ++SD F DFV +CL K+P++R
Sbjct: 259 ----------MIPTNP---------------PPTFRKPELWSDNFTDFVKQCLVKSPEQR 293
Query: 358 ADLKTLMNHEWIRKAEAEKV 377
A L+ H ++R A+ +
Sbjct: 294 ATATQLLQHPFVRSAKGVSI 313
>U66840-1|AAB40653.1| 352|Homo sapiens MAP kinase 3c protein.
Length = 352
Score = 176 bits (429), Expect = 1e-43
Identities = 92/211 (43%), Positives = 136/211 (64%), Gaps = 11/211 (5%)
Query: 84 ELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKV-LHE 142
E+ DD + ELG+G GVV KVRH +G IMA K I V +K+++ +L + +
Sbjct: 63 EVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRT 122
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDL----ILKKAGRIPESILGTITSAVLKG 198
+ + V FYGA + +G++ ICME MD SLD +L K IPE ILG I ++++
Sbjct: 123 VDCFYTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRA 181
Query: 199 LSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSF-VGTRSYMSPER- 256
L +L K +++HRDVKPSN+L+N G +K+CDFG+SG L+DS+A + G + YM+PER
Sbjct: 182 LEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERI 241
Query: 257 ---LQGTHYSVQSDIWSLGLSLVEMAIGMYP 284
L Y+V+SD+WSLG++++EMAI +P
Sbjct: 242 NPELNQKGYNVKSDVWSLGITMIEMAILRFP 272
Score = 63.7 bits (148), Expect = 1e-09
Identities = 30/69 (43%), Positives = 41/69 (59%)
Query: 319 FELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVD 378
F+ L +V EP P+LP+ FS EF DF +CL+KNP ER LM H + + +K D
Sbjct: 280 FQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTD 339
Query: 379 IAGWVCKTM 387
IA +V K +
Sbjct: 340 IAAFVKKIL 348
>U66839-1|AAB40652.1| 347|Homo sapiens MAP kinase 3b protein.
Length = 347
Score = 176 bits (429), Expect = 1e-43
Identities = 92/211 (43%), Positives = 136/211 (64%), Gaps = 11/211 (5%)
Query: 84 ELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKV-LHE 142
E+ DD + ELG+G GVV KVRH +G IMA K I V +K+++ +L + +
Sbjct: 58 EVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRT 117
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDL----ILKKAGRIPESILGTITSAVLKG 198
+ + V FYGA + +G++ ICME MD SLD +L K IPE ILG I ++++
Sbjct: 118 VDCFYTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRA 176
Query: 199 LSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSF-VGTRSYMSPER- 256
L +L K +++HRDVKPSN+L+N G +K+CDFG+SG L+DS+A + G + YM+PER
Sbjct: 177 LEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERI 236
Query: 257 ---LQGTHYSVQSDIWSLGLSLVEMAIGMYP 284
L Y+V+SD+WSLG++++EMAI +P
Sbjct: 237 NPELNQKGYNVKSDVWSLGITMIEMAILRFP 267
Score = 63.7 bits (148), Expect = 1e-09
Identities = 30/69 (43%), Positives = 41/69 (59%)
Query: 319 FELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVD 378
F+ L +V EP P+LP+ FS EF DF +CL+KNP ER LM H + + +K D
Sbjct: 275 FQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTD 334
Query: 379 IAGWVCKTM 387
IA +V K +
Sbjct: 335 IAAFVKKIL 343
>L36719-1|AAC41718.1| 318|Homo sapiens MAP kinase kinase 3 protein.
Length = 318
Score = 176 bits (429), Expect = 1e-43
Identities = 92/211 (43%), Positives = 136/211 (64%), Gaps = 11/211 (5%)
Query: 84 ELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKV-LHE 142
E+ DD + ELG+G GVV KVRH +G IMA K I V +K+++ +L + +
Sbjct: 29 EVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRT 88
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDL----ILKKAGRIPESILGTITSAVLKG 198
+ + V FYGA + +G++ ICME MD SLD +L K IPE ILG I ++++
Sbjct: 89 VDCFYTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRA 147
Query: 199 LSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSF-VGTRSYMSPER- 256
L +L K +++HRDVKPSN+L+N G +K+CDFG+SG L+DS+A + G + YM+PER
Sbjct: 148 LEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERI 207
Query: 257 ---LQGTHYSVQSDIWSLGLSLVEMAIGMYP 284
L Y+V+SD+WSLG++++EMAI +P
Sbjct: 208 NPELNQKGYNVKSDVWSLGITMIEMAILRFP 238
Score = 63.7 bits (148), Expect = 1e-09
Identities = 30/69 (43%), Positives = 41/69 (59%)
Query: 319 FELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVD 378
F+ L +V EP P+LP+ FS EF DF +CL+KNP ER LM H + + +K D
Sbjct: 246 FQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTD 305
Query: 379 IAGWVCKTM 387
IA +V K +
Sbjct: 306 IAAFVKKIL 314
>D87116-1|BAA13248.1| 347|Homo sapiens MAP kinase kinase 3b
protein.
Length = 347
Score = 176 bits (429), Expect = 1e-43
Identities = 92/211 (43%), Positives = 136/211 (64%), Gaps = 11/211 (5%)
Query: 84 ELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKV-LHE 142
E+ DD + ELG+G GVV KVRH +G IMA K I V +K+++ +L + +
Sbjct: 58 EVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRT 117
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDL----ILKKAGRIPESILGTITSAVLKG 198
+ + V FYGA + +G++ ICME MD SLD +L K IPE ILG I ++++
Sbjct: 118 VDCFYTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRA 176
Query: 199 LSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSF-VGTRSYMSPER- 256
L +L K +++HRDVKPSN+L+N G +K+CDFG+SG L+DS+A + G + YM+PER
Sbjct: 177 LEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERI 236
Query: 257 ---LQGTHYSVQSDIWSLGLSLVEMAIGMYP 284
L Y+V+SD+WSLG++++EMAI +P
Sbjct: 237 NPELNQKGYNVKSDVWSLGITMIEMAILRFP 267
Score = 62.5 bits (145), Expect = 3e-09
Identities = 29/65 (44%), Positives = 39/65 (60%)
Query: 319 FELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVD 378
F+ L +V EP P+LP+ FS EF DF +CL+KNP ER LM H + + +K D
Sbjct: 275 FQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTD 334
Query: 379 IAGWV 383
IA +V
Sbjct: 335 IAAFV 339
>CR536514-1|CAG38752.1| 347|Homo sapiens MAP2K3 protein.
Length = 347
Score = 176 bits (429), Expect = 1e-43
Identities = 92/211 (43%), Positives = 136/211 (64%), Gaps = 11/211 (5%)
Query: 84 ELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKV-LHE 142
E+ DD + ELG+G GVV KVRH +G IMA K I V +K+++ +L + +
Sbjct: 58 EVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRT 117
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDL----ILKKAGRIPESILGTITSAVLKG 198
+ + V FYGA + +G++ ICME MD SLD +L K IPE ILG I ++++
Sbjct: 118 VDCFYTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRA 176
Query: 199 LSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSF-VGTRSYMSPER- 256
L +L K +++HRDVKPSN+L+N G +K+CDFG+SG L+DS+A + G + YM+PER
Sbjct: 177 LEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERI 236
Query: 257 ---LQGTHYSVQSDIWSLGLSLVEMAIGMYP 284
L Y+V+SD+WSLG++++EMAI +P
Sbjct: 237 NPELNQKGYNVKSDVWSLGITMIEMAILRFP 267
Score = 62.5 bits (145), Expect = 3e-09
Identities = 29/65 (44%), Positives = 39/65 (60%)
Query: 319 FELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVD 378
F+ L +V EP P+LP+ FS EF DF +CL+KNP ER LM H + + +K D
Sbjct: 275 FQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTD 334
Query: 379 IAGWV 383
IA +V
Sbjct: 335 IAAFV 339
>BC032478-1|AAH32478.1| 347|Homo sapiens mitogen-activated protein
kinase kinase 3 protein.
Length = 347
Score = 176 bits (429), Expect = 1e-43
Identities = 92/211 (43%), Positives = 136/211 (64%), Gaps = 11/211 (5%)
Query: 84 ELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKV-LHE 142
E+ DD + ELG+G GVV KVRH +G IMA K I V +K+++ +L + +
Sbjct: 58 EVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRT 117
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDL----ILKKAGRIPESILGTITSAVLKG 198
+ + V FYGA + +G++ ICME MD SLD +L K IPE ILG I ++++
Sbjct: 118 VDCFYTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRA 176
Query: 199 LSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSF-VGTRSYMSPER- 256
L +L K +++HRDVKPSN+L+N G +K+CDFG+SG L+DS+A + G + YM+PER
Sbjct: 177 LEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERI 236
Query: 257 ---LQGTHYSVQSDIWSLGLSLVEMAIGMYP 284
L Y+V+SD+WSLG++++EMAI +P
Sbjct: 237 NPELNQKGYNVKSDVWSLGITMIEMAILRFP 267
Score = 62.5 bits (145), Expect = 3e-09
Identities = 29/65 (44%), Positives = 39/65 (60%)
Query: 319 FELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVD 378
F+ L +V EP P+LP+ FS EF DF +CL+KNP ER LM H + + +K D
Sbjct: 275 FQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTD 334
Query: 379 IAGWV 383
IA +V
Sbjct: 335 IAAFV 339
>DQ445915-1|ABE03013.1| 435|Homo sapiens mitogen-activated protein
kinase kinase 7 gamma 1 protein.
Length = 435
Score = 175 bits (426), Expect = 2e-43
Identities = 113/320 (35%), Positives = 171/320 (53%), Gaps = 37/320 (11%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVL---HECN 144
+D E LGE+G G G V K+R + TG ++A K + K+I+ +L V+ H+C
Sbjct: 134 NDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCP 193
Query: 145 FAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRD 204
+ IV +G F ++ ++ I ME M + L + G IPE ILG +T A++K L YL++
Sbjct: 194 Y--IVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKE 251
Query: 205 KHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANS-FVGTRSYMSPERLQ----- 258
KH ++HRDVKPSNIL++ G+IK+CDFG+SG+L+DS A + G +YM+PER+
Sbjct: 252 KHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPT 311
Query: 259 GTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAI 318
Y +++D+WSLG+SLVE+A G +P + KT + ++ + P P M
Sbjct: 312 KPDYDIRADVWSLGISLVELATGQFPY--KNCKTDFEVLTKVLQE----EPPLLPGHMGF 365
Query: 319 FELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVD 378
SG F KD CL K+ +R L+ H +I++ E +VD
Sbjct: 366 ----------------SGDFQSFVKD----CLTKDHRKRPKYNKLLEHSFIKRYETLEVD 405
Query: 379 IAGWVCKTMDLMPSTPNSNV 398
+A W M S S V
Sbjct: 406 VASWFKDVMAKTESPRTSGV 425
>CR541793-1|CAG46592.1| 347|Homo sapiens MAP2K3 protein.
Length = 347
Score = 175 bits (426), Expect = 2e-43
Identities = 92/211 (43%), Positives = 136/211 (64%), Gaps = 11/211 (5%)
Query: 84 ELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKV-LHE 142
E+ DD + ELG+G GVV KVRH +G IMA K I V +K+++ +L + +
Sbjct: 58 EVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMCT 117
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDL----ILKKAGRIPESILGTITSAVLKG 198
+ + V FYGA + +G++ ICME MD SLD +L K IPE ILG I ++++
Sbjct: 118 VDCFYTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRA 176
Query: 199 LSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSF-VGTRSYMSPER- 256
L +L K +++HRDVKPSN+L+N G +K+CDFG+SG L+DS+A + G + YM+PER
Sbjct: 177 LEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERI 236
Query: 257 ---LQGTHYSVQSDIWSLGLSLVEMAIGMYP 284
L Y+V+SD+WSLG++++EMAI +P
Sbjct: 237 NPELNQKGYNVKSDVWSLGITMIEMAILRFP 267
Score = 62.5 bits (145), Expect = 3e-09
Identities = 29/65 (44%), Positives = 39/65 (60%)
Query: 319 FELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVD 378
F+ L +V EP P+LP+ FS EF DF +CL+KNP ER LM H + + +K D
Sbjct: 275 FQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTD 334
Query: 379 IAGWV 383
IA +V
Sbjct: 335 IAAFV 339
>AF022805-1|AAC26142.1| 419|Homo sapiens c-Jun N-terminal kinase
kinase 2 protein.
Length = 419
Score = 175 bits (426), Expect = 2e-43
Identities = 113/320 (35%), Positives = 171/320 (53%), Gaps = 37/320 (11%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVL---HECN 144
+D E LGE+G G G V K+R + TG ++A K + K+I+ +L V+ H+C
Sbjct: 118 NDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCP 177
Query: 145 FAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRD 204
+ IV +G F ++ ++ I ME M + L + G IPE ILG +T A++K L YL++
Sbjct: 178 Y--IVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKE 235
Query: 205 KHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANS-FVGTRSYMSPERLQ----- 258
KH ++HRDVKPSNIL++ G+IK+CDFG+SG+L+DS A + G +YM+PER+
Sbjct: 236 KHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPT 295
Query: 259 GTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAI 318
Y +++D+WSLG+SLVE+A G +P + KT + ++ + P P M
Sbjct: 296 KPDYDIRADVWSLGISLVELATGQFPY--KNCKTDFEVLTKVLQE----EPPLLPGHMGF 349
Query: 319 FELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVD 378
SG F KD CL K+ +R L+ H +I++ E +VD
Sbjct: 350 ----------------SGDFQSFVKD----CLTKDHRKRPKYNKLLEHSFIKRYETLEVD 389
Query: 379 IAGWVCKTMDLMPSTPNSNV 398
+A W M S S V
Sbjct: 390 VASWFKDVMAKTESPRTSGV 409
>AF013589-1|AAC16273.1| 462|Homo sapiens mitogen-activated protein
kinase kinase 7b protein.
Length = 462
Score = 174 bits (424), Expect = 4e-43
Identities = 113/320 (35%), Positives = 170/320 (53%), Gaps = 37/320 (11%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVL---HECN 144
+D E LGE+G G G V K+R + TG ++A K + K+I+ +L V+ H+C
Sbjct: 161 NDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCP 220
Query: 145 FAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRD 204
+ IV +G F ++ ++ I ME M + L + G IPE ILG +T A++K L YL++
Sbjct: 221 Y--IVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKE 278
Query: 205 KHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANS-FVGTRSYMSPERLQ----- 258
KH ++HRDVKPSNIL++ G+IK CDFG+SG+L+DS A + G +YM+PER+
Sbjct: 279 KHGVIHRDVKPSNILLDERGQIKFCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPT 338
Query: 259 GTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAI 318
Y +++D+WSLG+SLVE+A G +P + KT + ++ + P P M
Sbjct: 339 KPDYDIRADVWSLGISLVELATGQFPY--KNCKTDFEVLTKVLQE----EPPLLPGHMGF 392
Query: 319 FELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVD 378
SG F KD CL K+ +R L+ H +I++ E +VD
Sbjct: 393 ----------------SGDFQSFVKD----CLTKDHRKRPKYNKLLEHSFIKRYETLEVD 432
Query: 379 IAGWVCKTMDLMPSTPNSNV 398
+A W M S S V
Sbjct: 433 VASWFKDVMAKTESPRTSGV 452
>AF013588-1|AAC16272.1| 419|Homo sapiens mitogen-activated protein
kinase kinase 7 protein.
Length = 419
Score = 174 bits (424), Expect = 4e-43
Identities = 113/320 (35%), Positives = 170/320 (53%), Gaps = 37/320 (11%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVL---HECN 144
+D E LGE+G G G V K+R + TG ++A K + K+I+ +L V+ H+C
Sbjct: 118 NDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCP 177
Query: 145 FAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRD 204
+ IV +G F ++ ++ I ME M + L + G IPE ILG +T A++K L YL++
Sbjct: 178 Y--IVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKE 235
Query: 205 KHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANS-FVGTRSYMSPERLQ----- 258
KH ++HRDVKPSNIL++ G+IK CDFG+SG+L+DS A + G +YM+PER+
Sbjct: 236 KHGVIHRDVKPSNILLDERGQIKFCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPT 295
Query: 259 GTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAI 318
Y +++D+WSLG+SLVE+A G +P + KT + ++ + P P M
Sbjct: 296 KPDYDIRADVWSLGISLVELATGQFPY--KNCKTDFEVLTKVLQE----EPPLLPGHMGF 349
Query: 319 FELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVD 378
SG F KD CL K+ +R L+ H +I++ E +VD
Sbjct: 350 ----------------SGDFQSFVKD----CLTKDHRKRPKYNKLLEHSFIKRYETLEVD 389
Query: 379 IAGWVCKTMDLMPSTPNSNV 398
+A W M S S V
Sbjct: 390 VASWFKDVMAKTESPRTSGV 409
>U39064-1|AAB03708.1| 278|Homo sapiens MAP kinase kinase 6 protein.
Length = 278
Score = 174 bits (423), Expect = 5e-43
Identities = 110/295 (37%), Positives = 163/295 (55%), Gaps = 30/295 (10%)
Query: 95 ELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKV-LHECNFAHIVGFYG 153
ELG+G GVV K+RH +G IMA K I V +K+++ +L + + + V FYG
Sbjct: 2 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 61
Query: 154 AFYSDGEISICMEYMDGGSLDLILK----KAGRIPESILGTITSAVLKGLSYLRDKHAIM 209
A + +G++ ICME MD SLD K K IPE ILG I +++K L +L K +++
Sbjct: 62 ALFREGDMWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVI 120
Query: 210 HRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSF-VGTRSYMSPERLQGTHYSVQSDI 268
HRDVKPSN+L+N+ G++K+CDFG+SG L+DS+A + G + YM+PER+ +
Sbjct: 121 HRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINP---ELNQKG 177
Query: 269 WSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIVNE 328
+S+ + + I M + AI P + +P F+ L +V E
Sbjct: 178 YSVKSDIWSLGITMIEL---------AIL------RFPYDSWGTP-----FQQLKQVVEE 217
Query: 329 PPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVDIAGWV 383
P P+LP+ FS EF DF +CLKKN ER LM H + E++ D+A +V
Sbjct: 218 PSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFV 272
>AK223490-1|BAD97210.1| 347|Homo sapiens mitogen-activated protein
kinase kinase 3 isoform B variant protein.
Length = 347
Score = 174 bits (423), Expect = 5e-43
Identities = 91/211 (43%), Positives = 135/211 (63%), Gaps = 11/211 (5%)
Query: 84 ELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKV-LHE 142
E+ DD + ELG+G GVV KVRH + IMA K I V +K+++ +L + +
Sbjct: 58 EVEADDLVTISELGRGAYGVVEKVRHAQSSTIMAVKRIRATVNSQEQKRLLMDLDINMRT 117
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDL----ILKKAGRIPESILGTITSAVLKG 198
+ + V FYGA + +G++ ICME MD SLD +L K IPE ILG I ++++
Sbjct: 118 VDCFYTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRA 176
Query: 199 LSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSF-VGTRSYMSPER- 256
L +L K +++HRDVKPSN+L+N G +K+CDFG+SG L+DS+A + G + YM+PER
Sbjct: 177 LEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERI 236
Query: 257 ---LQGTHYSVQSDIWSLGLSLVEMAIGMYP 284
L Y+V+SD+WSLG++++EMAI +P
Sbjct: 237 NPELNQKGYNVKSDVWSLGITMIEMAILRFP 267
Score = 62.5 bits (145), Expect = 3e-09
Identities = 29/65 (44%), Positives = 39/65 (60%)
Query: 319 FELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVD 378
F+ L +V EP P+LP+ FS EF DF +CL+KNP ER LM H + + +K D
Sbjct: 275 FQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTD 334
Query: 379 IAGWV 383
IA +V
Sbjct: 335 IAAFV 339
>AF006689-1|AAB97813.1| 401|Homo sapiens Jnkk2 protein.
Length = 401
Score = 174 bits (423), Expect = 5e-43
Identities = 109/304 (35%), Positives = 167/304 (54%), Gaps = 37/304 (12%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVL---HECN 144
+D E LGE+G G G V K+R + TG ++A K + K+I+ +L V+ H+C
Sbjct: 118 NDLENLGEMGSGTCGPVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCP 177
Query: 145 FAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRD 204
+ IV +G F ++ ++ I ME M + L + G IPE ILG +T A++K L YL++
Sbjct: 178 Y--IVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKE 235
Query: 205 KHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANS-FVGTRSYMSPERLQ----- 258
KH ++HRDVKPSNIL++ G+IK+CDFG+SG+L+DS A + G +YM+PER+
Sbjct: 236 KHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPT 295
Query: 259 GTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAI 318
Y +++D+WSLG+SLVE+A G +P + KT + ++ + P P M
Sbjct: 296 KPDYDIRADVWSLGISLVELATGQFPY--KNCKTDFEVLTKVLQE----EPPLLPGHMGF 349
Query: 319 FELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVD 378
SG F KD CL K+ +R L+ H +I++ E +VD
Sbjct: 350 ----------------SGDFQSFVKD----CLTKDHRKRPKYNKLLEHSFIKRYETLEVD 389
Query: 379 IAGW 382
+A W
Sbjct: 390 VASW 393
>U60206-1|AAB17261.1| 491|Homo sapiens serine/threonine protein
kinase Krs-1 protein.
Length = 491
Score = 173 bits (421), Expect = 9e-43
Identities = 103/298 (34%), Positives = 170/298 (57%), Gaps = 34/298 (11%)
Query: 79 KEKIGELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELK 138
++ + + ++ F+ L +LG+G+ G V K HK +G ++A K + +E + ++II+E+
Sbjct: 16 EDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE---SDLQEIIKEIS 72
Query: 139 VLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSL-DLILKKAGRIPESILGTITSAVLK 197
++ +C+ ++V +YG+++ + ++ I MEY GS+ D+I + + E + TI + LK
Sbjct: 73 IMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLK 132
Query: 198 GLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPE 255
GL YL I HRD+K NIL+N+ G K+ DFGV+GQL D+MA N+ +GT +M+PE
Sbjct: 133 GLEYLHFMRKI-HRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 191
Query: 256 RLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRP 315
+Q Y+ +DIWSLG++ +EMA G P D + AIF P +P
Sbjct: 192 VIQEIGYNCVADIWSLGITSIEMAEGKPPY--ADIHPMRAIF----------MIPTNP-- 237
Query: 316 MAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAE 373
PP ++SD+F DFV +CL KNP++RA L+ H +I+ A+
Sbjct: 238 -------------PPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAK 282
>U26424-1|AAC50386.1| 491|Homo sapiens MST2 protein.
Length = 491
Score = 173 bits (421), Expect = 9e-43
Identities = 103/298 (34%), Positives = 170/298 (57%), Gaps = 34/298 (11%)
Query: 79 KEKIGELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELK 138
++ + + ++ F+ L +LG+G+ G V K HK +G ++A K + +E + ++II+E+
Sbjct: 16 EDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE---SDLQEIIKEIS 72
Query: 139 VLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSL-DLILKKAGRIPESILGTITSAVLK 197
++ +C+ ++V +YG+++ + ++ I MEY GS+ D+I + + E + TI + LK
Sbjct: 73 IMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLK 132
Query: 198 GLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPE 255
GL YL I HRD+K NIL+N+ G K+ DFGV+GQL D+MA N+ +GT +M+PE
Sbjct: 133 GLEYLHFMRKI-HRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 191
Query: 256 RLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRP 315
+Q Y+ +DIWSLG++ +EMA G P D + AIF P +P
Sbjct: 192 VIQEIGYNCVADIWSLGITSIEMAEGKPPY--ADIHPMRAIF----------MIPTNP-- 237
Query: 316 MAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAE 373
PP ++SD+F DFV +CL KNP++RA L+ H +I+ A+
Sbjct: 238 -------------PPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAK 282
>BC010640-1|AAH10640.1| 491|Homo sapiens serine/threonine kinase 3
(STE20 homolog, yeast) protein.
Length = 491
Score = 173 bits (421), Expect = 9e-43
Identities = 103/298 (34%), Positives = 170/298 (57%), Gaps = 34/298 (11%)
Query: 79 KEKIGELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELK 138
++ + + ++ F+ L +LG+G+ G V K HK +G ++A K + +E + ++II+E+
Sbjct: 16 EDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE---SDLQEIIKEIS 72
Query: 139 VLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSL-DLILKKAGRIPESILGTITSAVLK 197
++ +C+ ++V +YG+++ + ++ I MEY GS+ D+I + + E + TI + LK
Sbjct: 73 IMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLK 132
Query: 198 GLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPE 255
GL YL I HRD+K NIL+N+ G K+ DFGV+GQL D+MA N+ +GT +M+PE
Sbjct: 133 GLEYLHFMRKI-HRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 191
Query: 256 RLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRP 315
+Q Y+ +DIWSLG++ +EMA G P D + AIF P +P
Sbjct: 192 VIQEIGYNCVADIWSLGITSIEMAEGKPPY--ADIHPMRAIF----------MIPTNP-- 237
Query: 316 MAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAE 373
PP ++SD+F DFV +CL KNP++RA L+ H +I+ A+
Sbjct: 238 -------------PPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAK 282
>AF014401-1|AAB88048.1| 419|Homo sapiens JNK kinase 2 protein.
Length = 419
Score = 173 bits (421), Expect = 9e-43
Identities = 112/320 (35%), Positives = 170/320 (53%), Gaps = 37/320 (11%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVL---HECN 144
+D E LGE+G G G V K+R + G ++A K + K+I+ +L V+ H+C
Sbjct: 118 NDLENLGEMGSGTCGQVWKMRFRKNGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCP 177
Query: 145 FAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRD 204
+ IV +G F ++ ++ I ME M + L + G IPE ILG +T A++K L YL++
Sbjct: 178 Y--IVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKE 235
Query: 205 KHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANS-FVGTRSYMSPERLQ----- 258
KH ++HRDVKPSNIL++ G+IK+CDFG+SG+L+DS A + G +YM+PER+
Sbjct: 236 KHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPT 295
Query: 259 GTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAI 318
Y +++D+WSLG+SLVE+A G +P + KT + ++ + P P M
Sbjct: 296 KPDYDIRADVWSLGISLVELATGQFPY--KNCKTDFEVLTKVLQE----EPPLLPGHMGF 349
Query: 319 FELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVD 378
SG F KD CL K+ +R L+ H +I++ E +VD
Sbjct: 350 ----------------SGDFQSFVKD----CLTKDHRKRPKYNKLLEHSFIKRYETLEVD 389
Query: 379 IAGWVCKTMDLMPSTPNSNV 398
+A W M S S V
Sbjct: 390 VASWFKDVMAKTESPRTSGV 409
>BC099843-1|AAH99843.1| 416|Homo sapiens serine/threonine protein
kinase MST4 protein.
Length = 416
Score = 164 bits (398), Expect = 6e-40
Identities = 103/285 (36%), Positives = 161/285 (56%), Gaps = 35/285 (12%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
F KL +G+G+ G V K T ++A K+I LE + I +E+ VL +C+ +++
Sbjct: 24 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVT 83
Query: 150 GFYGAFYSDGEISICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
+YG++ ++ I MEY+ GGS LDL+ +AG E + T+ +LKGL YL + I
Sbjct: 84 KYYGSYLKGSKLWIIMEYLGGGSALDLL--RAGPFDEFQIATMLKEILKGLDYLHSEKKI 141
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQS 266
HRD+K +N+L++ G++K+ DFGV+GQL D+ N+FVGT +M+PE +Q + Y ++
Sbjct: 142 -HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKA 200
Query: 267 DIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIV 326
DIWSLG++ +E+A G PP N D PM + L+
Sbjct: 201 DIWSLGITAIELAKG----EPP------------NSD---------MHPMRVLFLIP--K 233
Query: 327 NEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRK 371
N PP + G F++ FK+F+D CL K+P R K L+ H++I K
Sbjct: 234 NNPPTLV--GDFTESFKEFIDACLNKDPSFRPTAKELLKHKFIVK 276
>BT020099-1|AAV38902.1| 416|Homo sapiens Mst3 and SOK1-related
kinase protein.
Length = 416
Score = 163 bits (395), Expect = 1e-39
Identities = 103/285 (36%), Positives = 160/285 (56%), Gaps = 35/285 (12%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
F KL +G+G+ G V K T ++A K+I LE + I +E+ VL +C+ +++
Sbjct: 24 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVT 83
Query: 150 GFYGAFYSDGEISICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
+YG++ ++ I MEY+ GGS LDL+ +AG E + T+ +LKGL YL + I
Sbjct: 84 KYYGSYLKGSKLWIIMEYLGGGSALDLL--RAGPFDEFQIATMLKEILKGLDYLHSEKKI 141
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQS 266
HRD+K +N+L++ G++K+ DFGV+GQL D+ N+FVGT +M+PE +Q + Y ++
Sbjct: 142 -HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKA 200
Query: 267 DIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIV 326
DIWSLG++ +E+A G PP N D PM + L+
Sbjct: 201 DIWSLGITAIELAKG----EPP------------NSD---------MHPMRVLFLIP--K 233
Query: 327 NEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRK 371
N PP + G F+ FK+F+D CL K+P R K L+ H++I K
Sbjct: 234 NNPPTLV--GDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVK 276
>BC103503-1|AAI03504.1| 416|Homo sapiens serine/threonine protein
kinase MST4 protein.
Length = 416
Score = 163 bits (395), Expect = 1e-39
Identities = 103/285 (36%), Positives = 160/285 (56%), Gaps = 35/285 (12%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
F KL +G+G+ G V K T ++A K+I LE + I +E+ VL +C+ +++
Sbjct: 24 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVT 83
Query: 150 GFYGAFYSDGEISICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
+YG++ ++ I MEY+ GGS LDL+ +AG E + T+ +LKGL YL + I
Sbjct: 84 KYYGSYLKGSKLWIIMEYLGGGSALDLL--RAGPFDEFQIATMLKEILKGLDYLHSEKKI 141
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQS 266
HRD+K +N+L++ G++K+ DFGV+GQL D+ N+FVGT +M+PE +Q + Y ++
Sbjct: 142 -HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKA 200
Query: 267 DIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIV 326
DIWSLG++ +E+A G PP N D PM + L+
Sbjct: 201 DIWSLGITAIELAKG----EPP------------NSD---------MHPMRVLFLIP--K 233
Query: 327 NEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRK 371
N PP + G F+ FK+F+D CL K+P R K L+ H++I K
Sbjct: 234 NNPPTLV--GDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVK 276
>BC098315-1|AAH98315.1| 416|Homo sapiens serine/threonine protein
kinase MST4 protein.
Length = 416
Score = 163 bits (395), Expect = 1e-39
Identities = 103/285 (36%), Positives = 160/285 (56%), Gaps = 35/285 (12%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
F KL +G+G+ G V K T ++A K+I LE + I +E+ VL +C+ +++
Sbjct: 24 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVT 83
Query: 150 GFYGAFYSDGEISICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
+YG++ ++ I MEY+ GGS LDL+ +AG E + T+ +LKGL YL + I
Sbjct: 84 KYYGSYLKGSKLWIIMEYLGGGSALDLL--RAGPFDEFQIATMLKEILKGLDYLHSEKKI 141
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQS 266
HRD+K +N+L++ G++K+ DFGV+GQL D+ N+FVGT +M+PE +Q + Y ++
Sbjct: 142 -HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKA 200
Query: 267 DIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIV 326
DIWSLG++ +E+A G PP N D PM + L+
Sbjct: 201 DIWSLGITAIELAKG----EPP------------NSD---------MHPMRVLFLIP--K 233
Query: 327 NEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRK 371
N PP + G F+ FK+F+D CL K+P R K L+ H++I K
Sbjct: 234 NNPPTLV--GDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVK 276
>AL109749-1|CAI42079.1| 416|Homo sapiens Mst3 and SOK1-related
kinase (MST4) protein.
Length = 416
Score = 163 bits (395), Expect = 1e-39
Identities = 103/285 (36%), Positives = 160/285 (56%), Gaps = 35/285 (12%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
F KL +G+G+ G V K T ++A K+I LE + I +E+ VL +C+ +++
Sbjct: 24 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVT 83
Query: 150 GFYGAFYSDGEISICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
+YG++ ++ I MEY+ GGS LDL+ +AG E + T+ +LKGL YL + I
Sbjct: 84 KYYGSYLKGSKLWIIMEYLGGGSALDLL--RAGPFDEFQIATMLKEILKGLDYLHSEKKI 141
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQS 266
HRD+K +N+L++ G++K+ DFGV+GQL D+ N+FVGT +M+PE +Q + Y ++
Sbjct: 142 -HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKA 200
Query: 267 DIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIV 326
DIWSLG++ +E+A G PP N D PM + L+
Sbjct: 201 DIWSLGITAIELAKG----EPP------------NSD---------MHPMRVLFLIP--K 233
Query: 327 NEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRK 371
N PP + G F+ FK+F+D CL K+P R K L+ H++I K
Sbjct: 234 NNPPTLV--GDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVK 276
>AK075150-1|BAC11435.1| 392|Homo sapiens protein ( Homo sapiens
cDNA FLJ90669 fis, clone PLACE1005519, moderately
similar to Homo sapiens STE20-like kinase 3 (mst-3)
mRNA. ).
Length = 392
Score = 163 bits (395), Expect = 1e-39
Identities = 103/285 (36%), Positives = 160/285 (56%), Gaps = 35/285 (12%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
F KL +G+G+ G V K T ++A K+I LE + I +E+ VL +C+ +++
Sbjct: 24 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVT 83
Query: 150 GFYGAFYSDGEISICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
+YG++ ++ I MEY+ GGS LDL+ +AG E + T+ +LKGL YL + I
Sbjct: 84 KYYGSYLKGSKLWIIMEYLGGGSALDLL--RAGPFDEFQIATMLKEILKGLDYLHSEKKI 141
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQS 266
HRD+K +N+L++ G++K+ DFGV+GQL D+ N+FVGT +M+PE +Q + Y ++
Sbjct: 142 -HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKA 200
Query: 267 DIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIV 326
DIWSLG++ +E+A G PP N D PM + L+
Sbjct: 201 DIWSLGITAIELAKG----EPP------------NSD---------MHPMRVLFLIP--K 233
Query: 327 NEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRK 371
N PP + G F+ FK+F+D CL K+P R K L+ H++I K
Sbjct: 234 NNPPTLV--GDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVK 276
>AF344882-1|AAK29620.1| 416|Homo sapiens serine/threonine protein
kinase MST4 protein.
Length = 416
Score = 163 bits (395), Expect = 1e-39
Identities = 103/285 (36%), Positives = 160/285 (56%), Gaps = 35/285 (12%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
F KL +G+G+ G V K T ++A K+I LE + I +E+ VL +C+ +++
Sbjct: 24 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVT 83
Query: 150 GFYGAFYSDGEISICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
+YG++ ++ I MEY+ GGS LDL+ +AG E + T+ +LKGL YL + I
Sbjct: 84 KYYGSYLKGSKLWIIMEYLGGGSALDLL--RAGPFDEFQIATMLKEILKGLDYLHSEKKI 141
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQS 266
HRD+K +N+L++ G++K+ DFGV+GQL D+ N+FVGT +M+PE +Q + Y ++
Sbjct: 142 -HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKA 200
Query: 267 DIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIV 326
DIWSLG++ +E+A G PP N D PM + L+
Sbjct: 201 DIWSLGITAIELAKG----EPP------------NSD---------MHPMRVLFLIP--K 233
Query: 327 NEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRK 371
N PP + G F+ FK+F+D CL K+P R K L+ H++I K
Sbjct: 234 NNPPTLV--GDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVK 276
>AF231012-1|AAK38484.1| 416|Homo sapiens STE20-like kinase MST4
protein.
Length = 416
Score = 163 bits (395), Expect = 1e-39
Identities = 103/285 (36%), Positives = 160/285 (56%), Gaps = 35/285 (12%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
F KL +G+G+ G V K T ++A K+I LE + I +E+ VL +C+ +++
Sbjct: 24 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVT 83
Query: 150 GFYGAFYSDGEISICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
+YG++ ++ I MEY+ GGS LDL+ +AG E + T+ +LKGL YL + I
Sbjct: 84 KYYGSYLKGSKLWIIMEYLGGGSALDLL--RAGPFDEFQIATMLKEILKGLDYLHSEKKI 141
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQS 266
HRD+K +N+L++ G++K+ DFGV+GQL D+ N+FVGT +M+PE +Q + Y ++
Sbjct: 142 -HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKA 200
Query: 267 DIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIV 326
DIWSLG++ +E+A G PP N D PM + L+
Sbjct: 201 DIWSLGITAIELAKG----EPP------------NSD---------MHPMRVLFLIP--K 233
Query: 327 NEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRK 371
N PP + G F+ FK+F+D CL K+P R K L+ H++I K
Sbjct: 234 NNPPTLV--GDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVK 276
>AB040057-1|BAA92785.2| 416|Homo sapiens serine/threonine protein
kinase MASK protein.
Length = 416
Score = 163 bits (395), Expect = 1e-39
Identities = 103/285 (36%), Positives = 160/285 (56%), Gaps = 35/285 (12%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
F KL +G+G+ G V K T ++A K+I LE + I +E+ VL +C+ +++
Sbjct: 24 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVT 83
Query: 150 GFYGAFYSDGEISICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
+YG++ ++ I MEY+ GGS LDL+ +AG E + T+ +LKGL YL + I
Sbjct: 84 KYYGSYLKGSKLWIIMEYLGGGSALDLL--RAGPFDEFQIATMLKEILKGLDYLHSEKKI 141
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQS 266
HRD+K +N+L++ G++K+ DFGV+GQL D+ N+FVGT +M+PE +Q + Y ++
Sbjct: 142 -HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKA 200
Query: 267 DIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIV 326
DIWSLG++ +E+A G PP N D PM + L+
Sbjct: 201 DIWSLGITAIELAKG----EPP------------NSD---------MHPMRVLFLIP--K 233
Query: 327 NEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRK 371
N PP + G F+ FK+F+D CL K+P R K L+ H++I K
Sbjct: 234 NNPPTLV--GDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVK 276
>BT019619-1|AAV38425.1| 431|Homo sapiens serine/threonine kinase 24
(STE20 homolog, yeast) protein.
Length = 431
Score = 159 bits (387), Expect = 1e-38
Identities = 103/283 (36%), Positives = 160/283 (56%), Gaps = 35/283 (12%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
F KL ++G+G+ G V K T ++A K+I LE + I +E+ VL +C+ ++
Sbjct: 24 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVT 83
Query: 150 GFYGAFYSDGEISICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
+YG++ D ++ I MEY+ GGS LDL+ + G + E+ + TI +LKGL YL + I
Sbjct: 84 KYYGSYLKDTKLWIIMEYLGGGSALDLL--EPGPLDETQIATILREILKGLDYLHSEKKI 141
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQS 266
HRD+K +N+L++ +GE+K+ DFGV+GQL D+ N+FVGT +M+PE ++ + Y ++
Sbjct: 142 -HRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKA 200
Query: 267 DIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIV 326
DIWSLG++ +E+A G PP +E H PM + L I
Sbjct: 201 DIWSLGITAIELARG----EPP-----------HSELH----------PMKVLFL---IP 232
Query: 327 NEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PP L G +S K+FV+ CL K P R K L+ H++I
Sbjct: 233 KNNPPTL-EGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFI 274
>BC065378-1|AAH65378.1| 431|Homo sapiens serine/threonine kinase 24
(STE20 homolog, yeast) protein.
Length = 431
Score = 159 bits (387), Expect = 1e-38
Identities = 103/283 (36%), Positives = 160/283 (56%), Gaps = 35/283 (12%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
F KL ++G+G+ G V K T ++A K+I LE + I +E+ VL +C+ ++
Sbjct: 24 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVT 83
Query: 150 GFYGAFYSDGEISICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
+YG++ D ++ I MEY+ GGS LDL+ + G + E+ + TI +LKGL YL + I
Sbjct: 84 KYYGSYLKDTKLWIIMEYLGGGSALDLL--EPGPLDETQIATILREILKGLDYLHSEKKI 141
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQS 266
HRD+K +N+L++ +GE+K+ DFGV+GQL D+ N+FVGT +M+PE ++ + Y ++
Sbjct: 142 -HRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKA 200
Query: 267 DIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIV 326
DIWSLG++ +E+A G PP +E H PM + L I
Sbjct: 201 DIWSLGITAIELARG----EPP-----------HSELH----------PMKVLFL---IP 232
Query: 327 NEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PP L G +S K+FV+ CL K P R K L+ H++I
Sbjct: 233 KNNPPTL-EGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFI 274
>BC035578-1|AAH35578.1| 431|Homo sapiens serine/threonine kinase 24
(STE20 homolog, yeast) protein.
Length = 431
Score = 159 bits (387), Expect = 1e-38
Identities = 103/283 (36%), Positives = 160/283 (56%), Gaps = 35/283 (12%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
F KL ++G+G+ G V K T ++A K+I LE + I +E+ VL +C+ ++
Sbjct: 24 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVT 83
Query: 150 GFYGAFYSDGEISICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
+YG++ D ++ I MEY+ GGS LDL+ + G + E+ + TI +LKGL YL + I
Sbjct: 84 KYYGSYLKDTKLWIIMEYLGGGSALDLL--EPGPLDETQIATILREILKGLDYLHSEKKI 141
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQS 266
HRD+K +N+L++ +GE+K+ DFGV+GQL D+ N+FVGT +M+PE ++ + Y ++
Sbjct: 142 -HRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKA 200
Query: 267 DIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIV 326
DIWSLG++ +E+A G PP +E H PM + L I
Sbjct: 201 DIWSLGITAIELARG----EPP-----------HSELH----------PMKVLFL---IP 232
Query: 327 NEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PP L G +S K+FV+ CL K P R K L+ H++I
Sbjct: 233 KNNPPTL-EGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFI 274
>AL356423-3|CAI13115.1| 431|Homo sapiens serine/threonine kinase 24
(STE20 homolog, yeast) protein.
Length = 431
Score = 159 bits (387), Expect = 1e-38
Identities = 103/283 (36%), Positives = 160/283 (56%), Gaps = 35/283 (12%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
F KL ++G+G+ G V K T ++A K+I LE + I +E+ VL +C+ ++
Sbjct: 24 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVT 83
Query: 150 GFYGAFYSDGEISICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
+YG++ D ++ I MEY+ GGS LDL+ + G + E+ + TI +LKGL YL + I
Sbjct: 84 KYYGSYLKDTKLWIIMEYLGGGSALDLL--EPGPLDETQIATILREILKGLDYLHSEKKI 141
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQS 266
HRD+K +N+L++ +GE+K+ DFGV+GQL D+ N+FVGT +M+PE ++ + Y ++
Sbjct: 142 -HRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKA 200
Query: 267 DIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIV 326
DIWSLG++ +E+A G PP +E H PM + L I
Sbjct: 201 DIWSLGITAIELARG----EPP-----------HSELH----------PMKVLFL---IP 232
Query: 327 NEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PP L G +S K+FV+ CL K P R K L+ H++I
Sbjct: 233 KNNPPTL-EGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFI 274
>AL356423-2|CAI13114.1| 443|Homo sapiens serine/threonine kinase 24
(STE20 homolog, yeast) protein.
Length = 443
Score = 159 bits (387), Expect = 1e-38
Identities = 103/283 (36%), Positives = 160/283 (56%), Gaps = 35/283 (12%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
F KL ++G+G+ G V K T ++A K+I LE + I +E+ VL +C+ ++
Sbjct: 36 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVT 95
Query: 150 GFYGAFYSDGEISICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
+YG++ D ++ I MEY+ GGS LDL+ + G + E+ + TI +LKGL YL + I
Sbjct: 96 KYYGSYLKDTKLWIIMEYLGGGSALDLL--EPGPLDETQIATILREILKGLDYLHSEKKI 153
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQS 266
HRD+K +N+L++ +GE+K+ DFGV+GQL D+ N+FVGT +M+PE ++ + Y ++
Sbjct: 154 -HRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKA 212
Query: 267 DIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIV 326
DIWSLG++ +E+A G PP +E H PM + L I
Sbjct: 213 DIWSLGITAIELARG----EPP-----------HSELH----------PMKVLFL---IP 244
Query: 327 NEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PP L G +S K+FV+ CL K P R K L+ H++I
Sbjct: 245 KNNPPTL-EGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFI 286
>AL137249-7|CAI39457.1| 431|Homo sapiens serine/threonine kinase 24
(STE20 homolog, yeast) protein.
Length = 431
Score = 159 bits (387), Expect = 1e-38
Identities = 103/283 (36%), Positives = 160/283 (56%), Gaps = 35/283 (12%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
F KL ++G+G+ G V K T ++A K+I LE + I +E+ VL +C+ ++
Sbjct: 24 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVT 83
Query: 150 GFYGAFYSDGEISICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
+YG++ D ++ I MEY+ GGS LDL+ + G + E+ + TI +LKGL YL + I
Sbjct: 84 KYYGSYLKDTKLWIIMEYLGGGSALDLL--EPGPLDETQIATILREILKGLDYLHSEKKI 141
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQS 266
HRD+K +N+L++ +GE+K+ DFGV+GQL D+ N+FVGT +M+PE ++ + Y ++
Sbjct: 142 -HRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKA 200
Query: 267 DIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIV 326
DIWSLG++ +E+A G PP +E H PM + L I
Sbjct: 201 DIWSLGITAIELARG----EPP-----------HSELH----------PMKVLFL---IP 232
Query: 327 NEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PP L G +S K+FV+ CL K P R K L+ H++I
Sbjct: 233 KNNPPTL-EGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFI 274
>AL137249-3|CAI39453.1| 443|Homo sapiens serine/threonine kinase 24
(STE20 homolog, yeast) protein.
Length = 443
Score = 159 bits (387), Expect = 1e-38
Identities = 103/283 (36%), Positives = 160/283 (56%), Gaps = 35/283 (12%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
F KL ++G+G+ G V K T ++A K+I LE + I +E+ VL +C+ ++
Sbjct: 36 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVT 95
Query: 150 GFYGAFYSDGEISICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
+YG++ D ++ I MEY+ GGS LDL+ + G + E+ + TI +LKGL YL + I
Sbjct: 96 KYYGSYLKDTKLWIIMEYLGGGSALDLL--EPGPLDETQIATILREILKGLDYLHSEKKI 153
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQS 266
HRD+K +N+L++ +GE+K+ DFGV+GQL D+ N+FVGT +M+PE ++ + Y ++
Sbjct: 154 -HRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKA 212
Query: 267 DIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIV 326
DIWSLG++ +E+A G PP +E H PM + L I
Sbjct: 213 DIWSLGITAIELARG----EPP-----------HSELH----------PMKVLFL---IP 244
Query: 327 NEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PP L G +S K+FV+ CL K P R K L+ H++I
Sbjct: 245 KNNPPTL-EGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFI 286
>AF083420-1|AAD42039.1| 443|Homo sapiens brain-specific STE20-like
protein kinase 3 protein.
Length = 443
Score = 159 bits (387), Expect = 1e-38
Identities = 103/283 (36%), Positives = 160/283 (56%), Gaps = 35/283 (12%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
F KL ++G+G+ G V K T ++A K+I LE + I +E+ VL +C+ ++
Sbjct: 36 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVT 95
Query: 150 GFYGAFYSDGEISICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
+YG++ D ++ I MEY+ GGS LDL+ + G + E+ + TI +LKGL YL + I
Sbjct: 96 KYYGSYLKDTKLWIIMEYLGGGSALDLL--EPGPLDETQIATILREILKGLDYLHSEKKI 153
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQS 266
HRD+K +N+L++ +GE+K+ DFGV+GQL D+ N+FVGT +M+PE ++ + Y ++
Sbjct: 154 -HRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKA 212
Query: 267 DIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIV 326
DIWSLG++ +E+A G PP +E H PM + L I
Sbjct: 213 DIWSLGITAIELARG----EPP-----------HSELH----------PMKVLFL---IP 244
Query: 327 NEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PP L G +S K+FV+ CL K P R K L+ H++I
Sbjct: 245 KNNPPTL-EGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFI 286
>AF024636-1|AAB82560.1| 431|Homo sapiens STE20-like kinase 3
protein.
Length = 431
Score = 159 bits (387), Expect = 1e-38
Identities = 103/283 (36%), Positives = 160/283 (56%), Gaps = 35/283 (12%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
F KL ++G+G+ G V K T ++A K+I LE + I +E+ VL +C+ ++
Sbjct: 24 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVT 83
Query: 150 GFYGAFYSDGEISICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
+YG++ D ++ I MEY+ GGS LDL+ + G + E+ + TI +LKGL YL + I
Sbjct: 84 KYYGSYLKDTKLWIIMEYLGGGSALDLL--EPGPLDETQIATILREILKGLDYLHSEKKI 141
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQS 266
HRD+K +N+L++ +GE+K+ DFGV+GQL D+ N+FVGT +M+PE ++ + Y ++
Sbjct: 142 -HRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKA 200
Query: 267 DIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIV 326
DIWSLG++ +E+A G PP +E H PM + L I
Sbjct: 201 DIWSLGITAIELARG----EPP-----------HSELH----------PMKVLFL---IP 232
Query: 327 NEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PP L G +S K+FV+ CL K P R K L+ H++I
Sbjct: 233 KNNPPTL-EGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFI 274
>X99325-1|CAA67700.1| 426|Homo sapiens Ste20-like kinase protein.
Length = 426
Score = 158 bits (383), Expect = 4e-38
Identities = 102/285 (35%), Positives = 157/285 (55%), Gaps = 35/285 (12%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
F KL +G+G+ G V K T ++A K+I LE + I +E+ VL +C+ +I
Sbjct: 20 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYIT 79
Query: 150 GFYGAFYSDGEISICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
++G++ ++ I MEY+ GGS LDL+ K G + E+ + TI +LKGL YL + I
Sbjct: 80 RYFGSYLKSTKLWIIMEYLGGGSALDLL--KPGPLEETYIATILREILKGLDYLHSERKI 137
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQS 266
HRD+K +N+L++ G++K+ DFGV+GQL D+ N+FVGT +M+PE ++ + Y ++
Sbjct: 138 -HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKA 196
Query: 267 DIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIV 326
DIWSLG++ +E+A G PP N D P +L I
Sbjct: 197 DIWSLGITAIELAKG----EPP------------NSDLHP------------MRVLFLIP 228
Query: 327 NEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRK 371
PP L G S FK+FV+ CL K+P R K L+ H++I +
Sbjct: 229 KNSPPTL-EGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITR 272
>D63780-1|BAA20420.1| 426|Homo sapiens YSK1 protein.
Length = 426
Score = 158 bits (383), Expect = 4e-38
Identities = 102/285 (35%), Positives = 157/285 (55%), Gaps = 35/285 (12%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
F KL +G+G+ G V K T ++A K+I LE + I +E+ VL +C+ +I
Sbjct: 20 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYIT 79
Query: 150 GFYGAFYSDGEISICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
++G++ ++ I MEY+ GGS LDL+ K G + E+ + TI +LKGL YL + I
Sbjct: 80 RYFGSYLKSTKLWIIMEYLGGGSALDLL--KPGPLEETYIATILREILKGLDYLHSERKI 137
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQS 266
HRD+K +N+L++ G++K+ DFGV+GQL D+ N+FVGT +M+PE ++ + Y ++
Sbjct: 138 -HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKA 196
Query: 267 DIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIV 326
DIWSLG++ +E+A G PP N D P +L I
Sbjct: 197 DIWSLGITAIELAKG----EPP------------NSDLHP------------MRVLFLIP 228
Query: 327 NEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRK 371
PP L G S FK+FV+ CL K+P R K L+ H++I +
Sbjct: 229 KNSPPTL-EGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITR 272
>DQ093965-1|AAY88740.1| 426|Homo sapiens serine/threonine kinase 25
(STE20 homolog, yeast) protein.
Length = 426
Score = 158 bits (383), Expect = 4e-38
Identities = 102/285 (35%), Positives = 157/285 (55%), Gaps = 35/285 (12%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
F KL +G+G+ G V K T ++A K+I LE + I +E+ VL +C+ +I
Sbjct: 20 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYIT 79
Query: 150 GFYGAFYSDGEISICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
++G++ ++ I MEY+ GGS LDL+ K G + E+ + TI +LKGL YL + I
Sbjct: 80 RYFGSYLKSTKLWIIMEYLGGGSALDLL--KPGPLEETYIATILREILKGLDYLHSERKI 137
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQS 266
HRD+K +N+L++ G++K+ DFGV+GQL D+ N+FVGT +M+PE ++ + Y ++
Sbjct: 138 -HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKA 196
Query: 267 DIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIV 326
DIWSLG++ +E+A G PP N D P +L I
Sbjct: 197 DIWSLGITAIELAKG----EPP------------NSDLHP------------MRVLFLIP 228
Query: 327 NEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRK 371
PP L G S FK+FV+ CL K+P R K L+ H++I +
Sbjct: 229 KNSPPTL-EGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITR 272
>BT019961-1|AAV38764.1| 426|Homo sapiens serine/threonine kinase 25
(STE20 homolog, yeast) protein.
Length = 426
Score = 158 bits (383), Expect = 4e-38
Identities = 102/285 (35%), Positives = 157/285 (55%), Gaps = 35/285 (12%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
F KL +G+G+ G V K T ++A K+I LE + I +E+ VL +C+ +I
Sbjct: 20 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYIT 79
Query: 150 GFYGAFYSDGEISICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
++G++ ++ I MEY+ GGS LDL+ K G + E+ + TI +LKGL YL + I
Sbjct: 80 RYFGSYLKSTKLWIIMEYLGGGSALDLL--KPGPLEETYIATILREILKGLDYLHSERKI 137
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQS 266
HRD+K +N+L++ G++K+ DFGV+GQL D+ N+FVGT +M+PE ++ + Y ++
Sbjct: 138 -HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKA 196
Query: 267 DIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIV 326
DIWSLG++ +E+A G PP N D P +L I
Sbjct: 197 DIWSLGITAIELAKG----EPP------------NSDLHP------------MRVLFLIP 228
Query: 327 NEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRK 371
PP L G S FK+FV+ CL K+P R K L+ H++I +
Sbjct: 229 KNSPPTL-EGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITR 272
>BC091505-1|AAH91505.1| 426|Homo sapiens STK25 protein protein.
Length = 426
Score = 158 bits (383), Expect = 4e-38
Identities = 102/285 (35%), Positives = 157/285 (55%), Gaps = 35/285 (12%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
F KL +G+G+ G V K T ++A K+I LE + I +E+ VL +C+ +I
Sbjct: 20 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYIT 79
Query: 150 GFYGAFYSDGEISICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
++G++ ++ I MEY+ GGS LDL+ K G + E+ + TI +LKGL YL + I
Sbjct: 80 RYFGSYLKSTKLWIIMEYLGGGSALDLL--KPGPLEETYIATILREILKGLDYLHSERKI 137
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQS 266
HRD+K +N+L++ G++K+ DFGV+GQL D+ N+FVGT +M+PE ++ + Y ++
Sbjct: 138 -HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKA 196
Query: 267 DIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIV 326
DIWSLG++ +E+A G PP N D P +L I
Sbjct: 197 DIWSLGITAIELAKG----EPP------------NSDLHP------------MRVLFLIP 228
Query: 327 NEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRK 371
PP L G S FK+FV+ CL K+P R K L+ H++I +
Sbjct: 229 KNSPPTL-EGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITR 272
>BC015793-1|AAH15793.1| 426|Homo sapiens STK25 protein protein.
Length = 426
Score = 158 bits (383), Expect = 4e-38
Identities = 102/285 (35%), Positives = 157/285 (55%), Gaps = 35/285 (12%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
F KL +G+G+ G V K T ++A K+I LE + I +E+ VL +C+ +I
Sbjct: 20 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYIT 79
Query: 150 GFYGAFYSDGEISICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
++G++ ++ I MEY+ GGS LDL+ K G + E+ + TI +LKGL YL + I
Sbjct: 80 RYFGSYLKSTKLWIIMEYLGGGSALDLL--KPGPLEETYIATILREILKGLDYLHSERKI 137
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQS 266
HRD+K +N+L++ G++K+ DFGV+GQL D+ N+FVGT +M+PE ++ + Y ++
Sbjct: 138 -HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKA 196
Query: 267 DIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIV 326
DIWSLG++ +E+A G PP N D P +L I
Sbjct: 197 DIWSLGITAIELAKG----EPP------------NSDLHP------------MRVLFLIP 228
Query: 327 NEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRK 371
PP L G S FK+FV+ CL K+P R K L+ H++I +
Sbjct: 229 KNSPPTL-EGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITR 272
>BC007852-1|AAH07852.1| 426|Homo sapiens serine/threonine kinase 25
(STE20 homolog, yeast) protein.
Length = 426
Score = 158 bits (383), Expect = 4e-38
Identities = 102/285 (35%), Positives = 157/285 (55%), Gaps = 35/285 (12%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
F KL +G+G+ G V K T ++A K+I LE + I +E+ VL +C+ +I
Sbjct: 20 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYIT 79
Query: 150 GFYGAFYSDGEISICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
++G++ ++ I MEY+ GGS LDL+ K G + E+ + TI +LKGL YL + I
Sbjct: 80 RYFGSYLKSTKLWIIMEYLGGGSALDLL--KPGPLEETYIATILREILKGLDYLHSERKI 137
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQS 266
HRD+K +N+L++ G++K+ DFGV+GQL D+ N+FVGT +M+PE ++ + Y ++
Sbjct: 138 -HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKA 196
Query: 267 DIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIV 326
DIWSLG++ +E+A G PP N D P +L I
Sbjct: 197 DIWSLGITAIELAKG----EPP------------NSDLHP------------MRVLFLIP 228
Query: 327 NEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRK 371
PP L G S FK+FV+ CL K+P R K L+ H++I +
Sbjct: 229 KNSPPTL-EGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITR 272
>AC110299-2|AAY14683.1| 426|Homo sapiens unknown protein.
Length = 426
Score = 158 bits (383), Expect = 4e-38
Identities = 102/285 (35%), Positives = 157/285 (55%), Gaps = 35/285 (12%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
F KL +G+G+ G V K T ++A K+I LE + I +E+ VL +C+ +I
Sbjct: 20 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYIT 79
Query: 150 GFYGAFYSDGEISICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
++G++ ++ I MEY+ GGS LDL+ K G + E+ + TI +LKGL YL + I
Sbjct: 80 RYFGSYLKSTKLWIIMEYLGGGSALDLL--KPGPLEETYIATILREILKGLDYLHSERKI 137
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQS 266
HRD+K +N+L++ G++K+ DFGV+GQL D+ N+FVGT +M+PE ++ + Y ++
Sbjct: 138 -HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKA 196
Query: 267 DIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIV 326
DIWSLG++ +E+A G PP N D P +L I
Sbjct: 197 DIWSLGITAIELAKG----EPP------------NSDLHP------------MRVLFLIP 228
Query: 327 NEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRK 371
PP L G S FK+FV+ CL K+P R K L+ H++I +
Sbjct: 229 KNSPPTL-EGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITR 272
>CR542227-1|CAG47023.1| 431|Homo sapiens STK24 protein.
Length = 431
Score = 157 bits (381), Expect = 6e-38
Identities = 102/283 (36%), Positives = 159/283 (56%), Gaps = 35/283 (12%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
F KL ++G+G+ G V K T ++A K+I LE + I +E+ VL +C+ ++
Sbjct: 24 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVT 83
Query: 150 GFYGAFYSDGEISICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
+YG++ D ++ I MEY+ GGS LDL+ + G + E+ + TI +LKGL YL + I
Sbjct: 84 KYYGSYLKDTKLWIIMEYLGGGSALDLL--EPGPLDETQIATILREILKGLDYLHSEKKI 141
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQS 266
HRD+K +N+L++ +GE+K+ D GV+GQL D+ N+FVGT +M+PE ++ + Y ++
Sbjct: 142 -HRDIKAANVLLSEHGEVKLADIGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKA 200
Query: 267 DIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIV 326
DIWSLG++ +E+A G PP +E H PM + L I
Sbjct: 201 DIWSLGITAIELARG----EPP-----------HSELH----------PMKVLFL---IP 232
Query: 327 NEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PP L G +S K+FV+ CL K P R K L+ H++I
Sbjct: 233 KNNPPTL-EGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFI 274
>BC070077-1|AAH70077.1| 968|Homo sapiens serine/threonine kinase 10
protein.
Length = 968
Score = 147 bits (356), Expect = 7e-35
Identities = 94/295 (31%), Positives = 161/295 (54%), Gaps = 37/295 (12%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
+E +GELG G G V K ++K TG ++A K+I + + ++ I+ E+++L C+ +IV
Sbjct: 36 WEIVGELGDGAFGKVYKAKNKETGALVAAKVIETKSEEELEDYIV-EIEILATCDHPYIV 94
Query: 150 GFYGAFYSDGEISICMEYMDGGSLDLILKKAGR-IPESILGTITSAVLKGLSYLRDKHAI 208
GA+Y DG++ I +E+ GG++D I+ + R + E + + +L+ L++L K I
Sbjct: 95 KLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQEVCRQMLEALNFLHSKR-I 153
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSP-----ERLQGTH 261
+HRD+K N+L+ G+I++ DFGVS + + ++ +SF+GT +M+P E ++ T
Sbjct: 154 IHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTP 213
Query: 262 YSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFEL 321
Y ++DIWSLG++L+EMA I PP + PM + L
Sbjct: 214 YDYKADIWSLGITLIEMA----QIEPPH---------------------HELNPMRV--L 246
Query: 322 LDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEK 376
L ++PP L +S EF+DF+ L KNP+ R L+ H ++ + K
Sbjct: 247 LKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNK 301
>AB015718-1|BAA35073.1| 968|Homo sapiens protein kinase protein.
Length = 968
Score = 147 bits (355), Expect = 9e-35
Identities = 94/295 (31%), Positives = 160/295 (54%), Gaps = 37/295 (12%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
+E +GELG G G V K ++K TG + A K+I + + ++ I+ E+++L C+ +IV
Sbjct: 36 WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIV-EIEILATCDHPYIV 94
Query: 150 GFYGAFYSDGEISICMEYMDGGSLDLILKKAGR-IPESILGTITSAVLKGLSYLRDKHAI 208
GA+Y DG++ I +E+ GG++D I+ + R + E + + +L+ L++L K I
Sbjct: 95 KLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKR-I 153
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSP-----ERLQGTH 261
+HRD+K N+L+ G+I++ DFGVS + + ++ +SF+GT +M+P E ++ T
Sbjct: 154 IHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTP 213
Query: 262 YSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFEL 321
Y ++DIWSLG++L+EMA I PP + PM + L
Sbjct: 214 YDYKADIWSLGITLIEMA----QIEPPH---------------------HELNPMRV--L 246
Query: 322 LDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEK 376
L ++PP L +S EF+DF+ L KNP+ R L+ H ++ + K
Sbjct: 247 LKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNK 301
>D86959-1|BAA13195.2| 1164|Homo sapiens KIAA0204 protein protein.
Length = 1164
Score = 138 bits (335), Expect = 2e-32
Identities = 94/295 (31%), Positives = 157/295 (53%), Gaps = 38/295 (12%)
Query: 84 ELSDDDF-EKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE 142
+L+ +DF E +GELG G G V K ++K T ++ A K+I + + ++ ++ E+ +L
Sbjct: 39 DLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMV-EIDILAS 97
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGR-IPESILGTITSAVLKGLSY 201
C+ +IV AFY + + I +E+ GG++D ++ + R + ES + + L L+Y
Sbjct: 98 CDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNY 157
Query: 202 LRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERL-- 257
L D + I+HRD+K NIL +G+IK+ DFGVS + ++ +SF+GT +M+PE +
Sbjct: 158 LHD-NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMC 216
Query: 258 ---QGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPR 314
+ Y ++D+WSLG++L+EMA I PP +
Sbjct: 217 ETSKDRPYDYKADVWSLGITLIEMA----EIEPPH---------------------HELN 251
Query: 315 PMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PM + LL +EPP +S FKDF+ +CL+KN D R L+ H ++
Sbjct: 252 PMRV--LLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV 304
>BC111565-1|AAI11566.1| 1204|Homo sapiens SLK protein protein.
Length = 1204
Score = 138 bits (335), Expect = 2e-32
Identities = 94/295 (31%), Positives = 157/295 (53%), Gaps = 38/295 (12%)
Query: 84 ELSDDDF-EKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE 142
+L+ +DF E +GELG G G V K ++K T ++ A K+I + + ++ ++ E+ +L
Sbjct: 27 DLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMV-EIDILAS 85
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGR-IPESILGTITSAVLKGLSY 201
C+ +IV AFY + + I +E+ GG++D ++ + R + ES + + L L+Y
Sbjct: 86 CDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNY 145
Query: 202 LRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERL-- 257
L D + I+HRD+K NIL +G+IK+ DFGVS + ++ +SF+GT +M+PE +
Sbjct: 146 LHD-NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMC 204
Query: 258 ---QGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPR 314
+ Y ++D+WSLG++L+EMA I PP +
Sbjct: 205 ETSKDRPYDYKADVWSLGITLIEMA----EIEPPH---------------------HELN 239
Query: 315 PMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PM + LL +EPP +S FKDF+ +CL+KN D R L+ H ++
Sbjct: 240 PMRV--LLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV 292
>BC064804-1|AAH64804.1| 617|Homo sapiens SLK protein protein.
Length = 617
Score = 138 bits (335), Expect = 2e-32
Identities = 94/295 (31%), Positives = 157/295 (53%), Gaps = 38/295 (12%)
Query: 84 ELSDDDF-EKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE 142
+L+ +DF E +GELG G G V K ++K T ++ A K+I + + ++ ++ E+ +L
Sbjct: 27 DLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMV-EIDILAS 85
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGR-IPESILGTITSAVLKGLSY 201
C+ +IV AFY + + I +E+ GG++D ++ + R + ES + + L L+Y
Sbjct: 86 CDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNY 145
Query: 202 LRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERL-- 257
L D + I+HRD+K NIL +G+IK+ DFGVS + ++ +SF+GT +M+PE +
Sbjct: 146 LHD-NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMC 204
Query: 258 ---QGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPR 314
+ Y ++D+WSLG++L+EMA I PP +
Sbjct: 205 ETSKDRPYDYKADVWSLGITLIEMA----EIEPPH---------------------HELN 239
Query: 315 PMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PM + LL +EPP +S FKDF+ +CL+KN D R L+ H ++
Sbjct: 240 PMRV--LLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV 292
>BC047885-1|AAH47885.1| 426|Homo sapiens SLK protein protein.
Length = 426
Score = 138 bits (335), Expect = 2e-32
Identities = 94/295 (31%), Positives = 157/295 (53%), Gaps = 38/295 (12%)
Query: 84 ELSDDDF-EKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE 142
+L+ +DF E +GELG G G V K ++K T ++ A K+I + + ++ ++ E+ +L
Sbjct: 27 DLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMV-EIDILAS 85
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGR-IPESILGTITSAVLKGLSY 201
C+ +IV AFY + + I +E+ GG++D ++ + R + ES + + L L+Y
Sbjct: 86 CDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNY 145
Query: 202 LRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERL-- 257
L D + I+HRD+K NIL +G+IK+ DFGVS + ++ +SF+GT +M+PE +
Sbjct: 146 LHD-NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMC 204
Query: 258 ---QGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPR 314
+ Y ++D+WSLG++L+EMA I PP +
Sbjct: 205 ETSKDRPYDYKADVWSLGITLIEMA----EIEPPH---------------------HELN 239
Query: 315 PMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PM + LL +EPP +S FKDF+ +CL+KN D R L+ H ++
Sbjct: 240 PMRV--LLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV 292
>BC047762-1|AAH47762.1| 614|Homo sapiens SLK protein protein.
Length = 614
Score = 138 bits (335), Expect = 2e-32
Identities = 94/295 (31%), Positives = 157/295 (53%), Gaps = 38/295 (12%)
Query: 84 ELSDDDF-EKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE 142
+L+ +DF E +GELG G G V K ++K T ++ A K+I + + ++ ++ E+ +L
Sbjct: 27 DLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMV-EIDILAS 85
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGR-IPESILGTITSAVLKGLSY 201
C+ +IV AFY + + I +E+ GG++D ++ + R + ES + + L L+Y
Sbjct: 86 CDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNY 145
Query: 202 LRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERL-- 257
L D + I+HRD+K NIL +G+IK+ DFGVS + ++ +SF+GT +M+PE +
Sbjct: 146 LHD-NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMC 204
Query: 258 ---QGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPR 314
+ Y ++D+WSLG++L+EMA I PP +
Sbjct: 205 ETSKDRPYDYKADVWSLGITLIEMA----EIEPPH---------------------HELN 239
Query: 315 PMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PM + LL +EPP +S FKDF+ +CL+KN D R L+ H ++
Sbjct: 240 PMRV--LLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV 292
>AL360170-2|CAH70404.1| 1235|Homo sapiens Ste20-related
serine\/threonine kinase (SLK) protein.
Length = 1235
Score = 138 bits (335), Expect = 2e-32
Identities = 94/295 (31%), Positives = 157/295 (53%), Gaps = 38/295 (12%)
Query: 84 ELSDDDF-EKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE 142
+L+ +DF E +GELG G G V K ++K T ++ A K+I + + ++ ++ E+ +L
Sbjct: 27 DLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMV-EIDILAS 85
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGR-IPESILGTITSAVLKGLSY 201
C+ +IV AFY + + I +E+ GG++D ++ + R + ES + + L L+Y
Sbjct: 86 CDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNY 145
Query: 202 LRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERL-- 257
L D + I+HRD+K NIL +G+IK+ DFGVS + ++ +SF+GT +M+PE +
Sbjct: 146 LHD-NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMC 204
Query: 258 ---QGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPR 314
+ Y ++D+WSLG++L+EMA I PP +
Sbjct: 205 ETSKDRPYDYKADVWSLGITLIEMA----EIEPPH---------------------HELN 239
Query: 315 PMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PM + LL +EPP +S FKDF+ +CL+KN D R L+ H ++
Sbjct: 240 PMRV--LLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV 292
>AL360170-1|CAH70403.1| 1204|Homo sapiens Ste20-related
serine\/threonine kinase (SLK) protein.
Length = 1204
Score = 138 bits (335), Expect = 2e-32
Identities = 94/295 (31%), Positives = 157/295 (53%), Gaps = 38/295 (12%)
Query: 84 ELSDDDF-EKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE 142
+L+ +DF E +GELG G G V K ++K T ++ A K+I + + ++ ++ E+ +L
Sbjct: 27 DLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMV-EIDILAS 85
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGR-IPESILGTITSAVLKGLSY 201
C+ +IV AFY + + I +E+ GG++D ++ + R + ES + + L L+Y
Sbjct: 86 CDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNY 145
Query: 202 LRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERL-- 257
L D + I+HRD+K NIL +G+IK+ DFGVS + ++ +SF+GT +M+PE +
Sbjct: 146 LHD-NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMC 204
Query: 258 ---QGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPR 314
+ Y ++D+WSLG++L+EMA I PP +
Sbjct: 205 ETSKDRPYDYKADVWSLGITLIEMA----EIEPPH---------------------HELN 239
Query: 315 PMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PM + LL +EPP +S FKDF+ +CL+KN D R L+ H ++
Sbjct: 240 PMRV--LLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV 292
>AL138761-2|CAI12395.1| 1235|Homo sapiens Ste20-related
serine\/threonine kinase (SLK) protein.
Length = 1235
Score = 138 bits (335), Expect = 2e-32
Identities = 94/295 (31%), Positives = 157/295 (53%), Gaps = 38/295 (12%)
Query: 84 ELSDDDF-EKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE 142
+L+ +DF E +GELG G G V K ++K T ++ A K+I + + ++ ++ E+ +L
Sbjct: 27 DLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMV-EIDILAS 85
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGR-IPESILGTITSAVLKGLSY 201
C+ +IV AFY + + I +E+ GG++D ++ + R + ES + + L L+Y
Sbjct: 86 CDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNY 145
Query: 202 LRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERL-- 257
L D + I+HRD+K NIL +G+IK+ DFGVS + ++ +SF+GT +M+PE +
Sbjct: 146 LHD-NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMC 204
Query: 258 ---QGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPR 314
+ Y ++D+WSLG++L+EMA I PP +
Sbjct: 205 ETSKDRPYDYKADVWSLGITLIEMA----EIEPPH---------------------HELN 239
Query: 315 PMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PM + LL +EPP +S FKDF+ +CL+KN D R L+ H ++
Sbjct: 240 PMRV--LLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV 292
>AL138761-1|CAI12396.1| 1204|Homo sapiens Ste20-related
serine\/threonine kinase (SLK) protein.
Length = 1204
Score = 138 bits (335), Expect = 2e-32
Identities = 94/295 (31%), Positives = 157/295 (53%), Gaps = 38/295 (12%)
Query: 84 ELSDDDF-EKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE 142
+L+ +DF E +GELG G G V K ++K T ++ A K+I + + ++ ++ E+ +L
Sbjct: 27 DLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMV-EIDILAS 85
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGR-IPESILGTITSAVLKGLSY 201
C+ +IV AFY + + I +E+ GG++D ++ + R + ES + + L L+Y
Sbjct: 86 CDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNY 145
Query: 202 LRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERL-- 257
L D + I+HRD+K NIL +G+IK+ DFGVS + ++ +SF+GT +M+PE +
Sbjct: 146 LHD-NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMC 204
Query: 258 ---QGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPR 314
+ Y ++D+WSLG++L+EMA I PP +
Sbjct: 205 ETSKDRPYDYKADVWSLGITLIEMA----EIEPPH---------------------HELN 239
Query: 315 PMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PM + LL +EPP +S FKDF+ +CL+KN D R L+ H ++
Sbjct: 240 PMRV--LLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV 292
>AF273048-1|AAG34908.1| 1235|Homo sapiens CTCL tumor antigen se20-9
protein.
Length = 1235
Score = 138 bits (335), Expect = 2e-32
Identities = 94/295 (31%), Positives = 157/295 (53%), Gaps = 38/295 (12%)
Query: 84 ELSDDDF-EKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE 142
+L+ +DF E +GELG G G V K ++K T ++ A K+I + + ++ ++ E+ +L
Sbjct: 27 DLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMV-EIDILAS 85
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGR-IPESILGTITSAVLKGLSY 201
C+ +IV AFY + + I +E+ GG++D ++ + R + ES + + L L+Y
Sbjct: 86 CDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNY 145
Query: 202 LRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERL-- 257
L D + I+HRD+K NIL +G+IK+ DFGVS + ++ +SF+GT +M+PE +
Sbjct: 146 LHD-NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMC 204
Query: 258 ---QGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPR 314
+ Y ++D+WSLG++L+EMA I PP +
Sbjct: 205 ETSKDRPYDYKADVWSLGITLIEMA----EIEPPH---------------------HELN 239
Query: 315 PMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PM + LL +EPP +S FKDF+ +CL+KN D R L+ H ++
Sbjct: 240 PMRV--LLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV 292
>AB002804-1|BAA19655.1| 1204|Homo sapiens hSLK protein.
Length = 1204
Score = 138 bits (335), Expect = 2e-32
Identities = 94/295 (31%), Positives = 157/295 (53%), Gaps = 38/295 (12%)
Query: 84 ELSDDDF-EKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE 142
+L+ +DF E +GELG G G V K ++K T ++ A K+I + + ++ ++ E+ +L
Sbjct: 27 DLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMV-EIDILAS 85
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGR-IPESILGTITSAVLKGLSY 201
C+ +IV AFY + + I +E+ GG++D ++ + R + ES + + L L+Y
Sbjct: 86 CDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNY 145
Query: 202 LRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERL-- 257
L D + I+HRD+K NIL +G+IK+ DFGVS + ++ +SF+GT +M+PE +
Sbjct: 146 LHD-NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMC 204
Query: 258 ---QGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPR 314
+ Y ++D+WSLG++L+EMA I PP +
Sbjct: 205 ETSKDRPYDYKADVWSLGITLIEMA----EIEPPH---------------------HELN 239
Query: 315 PMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PM + LL +EPP +S FKDF+ +CL+KN D R L+ H ++
Sbjct: 240 PMRV--LLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV 292
>U66464-1|AAB97983.1| 833|Homo sapiens hematopoietic progenitor
kinase protein.
Length = 833
Score = 132 bits (320), Expect = 2e-30
Identities = 84/255 (32%), Positives = 139/255 (54%), Gaps = 12/255 (4%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAH 147
D ++ L LG G G V K R K +G ++A K++ +E + + +E+ +L C A+
Sbjct: 15 DHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVST-LQKEILILKTCRHAN 73
Query: 148 IVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHA 207
IV ++G++ ++ ICME+ GSL I + G + E + + VL+GL+YL +
Sbjct: 74 IVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKK 133
Query: 208 IMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMAN--SFVGTRSYMSPE----RLQGTH 261
I HRD+K +NIL+N GE+++ DFG+S Q+ ++A SF+GT +M+PE L+G
Sbjct: 134 I-HRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKG-G 191
Query: 262 YSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIF-E 320
Y+ DIWSLG++ +E+A + P P D L +F + P + + A F
Sbjct: 192 YNELCDIWSLGITAIELA-ELQP-PLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHN 249
Query: 321 LLDYIVNEPPPKLPS 335
+ + + P K PS
Sbjct: 250 FIKVTLTKSPKKRPS 264
>AL356423-1|CAI13113.1| 368|Homo sapiens serine/threonine kinase 24
(STE20 homolog, yeast) protein.
Length = 368
Score = 130 bits (315), Expect = 6e-30
Identities = 84/222 (37%), Positives = 127/222 (57%), Gaps = 35/222 (15%)
Query: 151 FYGAFYSDGEISICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAIM 209
+YG++ D ++ I MEY+ GGS LDL+ + G + E+ + TI +LKGL YL + I
Sbjct: 2 YYGSYLKDTKLWIIMEYLGGGSALDLL--EPGPLDETQIATILREILKGLDYLHSEKKI- 58
Query: 210 HRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQSD 267
HRD+K +N+L++ +GE+K+ DFGV+GQL D+ N+FVGT +M+PE ++ + Y ++D
Sbjct: 59 HRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKAD 118
Query: 268 IWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIVN 327
IWSLG++ +E+A G PP +E H PM + L I
Sbjct: 119 IWSLGITAIELARG----EPP-----------HSELH----------PMKVLFL---IPK 150
Query: 328 EPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PP L G +S K+FV+ CL K P R K L+ H++I
Sbjct: 151 NNPPTL-EGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFI 191
>AL137249-2|CAI39452.1| 368|Homo sapiens serine/threonine kinase 24
(STE20 homolog, yeast) protein.
Length = 368
Score = 130 bits (315), Expect = 6e-30
Identities = 84/222 (37%), Positives = 127/222 (57%), Gaps = 35/222 (15%)
Query: 151 FYGAFYSDGEISICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAIM 209
+YG++ D ++ I MEY+ GGS LDL+ + G + E+ + TI +LKGL YL + I
Sbjct: 2 YYGSYLKDTKLWIIMEYLGGGSALDLL--EPGPLDETQIATILREILKGLDYLHSEKKI- 58
Query: 210 HRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQSD 267
HRD+K +N+L++ +GE+K+ DFGV+GQL D+ N+FVGT +M+PE ++ + Y ++D
Sbjct: 59 HRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKAD 118
Query: 268 IWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIVN 327
IWSLG++ +E+A G PP +E H PM + L I
Sbjct: 119 IWSLGITAIELARG----EPP-----------HSELH----------PMKVLFL---IPK 150
Query: 328 EPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PP L G +S K+FV+ CL K P R K L+ H++I
Sbjct: 151 NNPPTL-EGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFI 191
>BC041799-1|AAH41799.1| 592|Homo sapiens CDKL3 protein protein.
Length = 592
Score = 130 bits (313), Expect = 1e-29
Identities = 84/286 (29%), Positives = 142/286 (49%), Gaps = 5/286 (1%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
+E LG++G+G+ G VMK +HK+TG I+A K+ + + ++ K +RE+K L + + ++V
Sbjct: 4 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHENLV 63
Query: 150 GFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAIM 209
F +I + E++D LD + + L +L+ + YL + I+
Sbjct: 64 NLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNN-II 122
Query: 210 HRDVKPSNILVNSNGEIKICDFGVSGQLI--DSMANSFVGTRSYMSPER-LQGTHYSVQS 266
HRD+KP NILV+ +G K+CDFG + L + +V TR Y +PE L+ T Y
Sbjct: 123 HRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGKPV 182
Query: 267 DIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPG-QAPNSPRPMAIFELLDYI 325
DIW+LG ++EMA G +P L + + SP Q S P+ +L +
Sbjct: 183 DIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLPQV 242
Query: 326 VNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRK 371
+ + + D V CL+ +P +R L++HE+ +
Sbjct: 243 QHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTR 288
>AF130372-1|AAF36509.1| 455|Homo sapiens serine-threonine protein
kinase NKIAMRE protein.
Length = 455
Score = 130 bits (313), Expect = 1e-29
Identities = 84/286 (29%), Positives = 142/286 (49%), Gaps = 5/286 (1%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
+E LG++G+G+ G VMK +HK+TG I+A K+ + + ++ K +RE+K L + + ++V
Sbjct: 4 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHENLV 63
Query: 150 GFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAIM 209
F +I + E++D LD + + L +L+ + YL + I+
Sbjct: 64 NLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNN-II 122
Query: 210 HRDVKPSNILVNSNGEIKICDFGVSGQLI--DSMANSFVGTRSYMSPER-LQGTHYSVQS 266
HRD+KP NILV+ +G K+CDFG + L + +V TR Y +PE L+ T Y
Sbjct: 123 HRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGKPV 182
Query: 267 DIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPG-QAPNSPRPMAIFELLDYI 325
DIW+LG ++EMA G +P L + + SP Q S P+ +L +
Sbjct: 183 DIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLPQV 242
Query: 326 VNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRK 371
+ + + D V CL+ +P +R L++HE+ +
Sbjct: 243 QHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTR 288
>AF000145-1|AAC15472.1| 884|Homo sapiens germinal center kinase
related protein kinase protein.
Length = 884
Score = 129 bits (312), Expect = 1e-29
Identities = 89/291 (30%), Positives = 149/291 (51%), Gaps = 34/291 (11%)
Query: 85 LSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIR-ELKVLHEC 143
++ +DFE + +G G G V K R+ +TG + A K+I LE P +++ E+ ++ +C
Sbjct: 1 MAQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLE--PGEDFAVVQQEIIMMKDC 58
Query: 144 NFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLR 203
+IV ++G++ ++ ICME+ GGSL I G + E + ++ L+GL YL
Sbjct: 59 KHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLH 118
Query: 204 DKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPERL---Q 258
K MHRD+K +NIL+ NG +K+ DFGVS Q+ ++A SF+GT +M+PE +
Sbjct: 119 SK-GKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVER 177
Query: 259 GTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAI 318
Y+ D+W++G++ +E+A + PP +F PM
Sbjct: 178 KGGYNQLCDLWAVGITAIELA----ELQPP-------MF--------------DLHPMRA 212
Query: 319 FELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
L+ +PP +S+ F FV L KNP +R + L+ H ++
Sbjct: 213 LFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV 263
>BC071579-1|AAH71579.1| 873|Homo sapiens MAP4K3 protein protein.
Length = 873
Score = 128 bits (309), Expect = 3e-29
Identities = 89/288 (30%), Positives = 147/288 (51%), Gaps = 34/288 (11%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIR-ELKVLHECNFA 146
+DFE + +G G G V K R+ +TG + A K+I LE P +++ E+ ++ +C
Sbjct: 14 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLE--PGEDFAVVQQEIIMMKDCKHP 71
Query: 147 HIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKH 206
+IV ++G++ ++ ICME+ GGSL I G + E + ++ L+GL YL K
Sbjct: 72 NIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSK- 130
Query: 207 AIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPERL---QGTH 261
MHRD+K +NIL+ NG +K+ DFGVS Q+ ++A SF+GT +M+PE +
Sbjct: 131 GKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGG 190
Query: 262 YSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFEL 321
Y+ D+W++G++ +E+A + PP +F PM L
Sbjct: 191 YNQLCDLWAVGITAIELA----ELQPP-------MF--------------DLHPMRALFL 225
Query: 322 LDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
+ +PP +S+ F FV L KNP +R + L+ H ++
Sbjct: 226 MTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV 273
>AF445413-2|AAN75850.1| 873|Homo sapiens MAP4K3 protein.
Length = 873
Score = 128 bits (309), Expect = 3e-29
Identities = 89/288 (30%), Positives = 147/288 (51%), Gaps = 34/288 (11%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIR-ELKVLHECNFA 146
+DFE + +G G G V K R+ +TG + A K+I LE P +++ E+ ++ +C
Sbjct: 14 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLE--PGEDFAVVQQEIIMMKDCKHP 71
Query: 147 HIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKH 206
+IV ++G++ ++ ICME+ GGSL I G + E + ++ L+GL YL K
Sbjct: 72 NIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSK- 130
Query: 207 AIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPERL---QGTH 261
MHRD+K +NIL+ NG +K+ DFGVS Q+ ++A SF+GT +M+PE +
Sbjct: 131 GKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGG 190
Query: 262 YSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFEL 321
Y+ D+W++G++ +E+A + PP +F PM L
Sbjct: 191 YNQLCDLWAVGITAIELA----ELQPP-------MF--------------DLHPMRALFL 225
Query: 322 LDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
+ +PP +S+ F FV L KNP +R + L+ H ++
Sbjct: 226 MTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV 273
>AF445413-1|AAN75849.1| 894|Homo sapiens MAP4K3 protein.
Length = 894
Score = 128 bits (309), Expect = 3e-29
Identities = 89/288 (30%), Positives = 147/288 (51%), Gaps = 34/288 (11%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIR-ELKVLHECNFA 146
+DFE + +G G G V K R+ +TG + A K+I LE P +++ E+ ++ +C
Sbjct: 14 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLE--PGEDFAVVQQEIIMMKDCKHP 71
Query: 147 HIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKH 206
+IV ++G++ ++ ICME+ GGSL I G + E + ++ L+GL YL K
Sbjct: 72 NIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSK- 130
Query: 207 AIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPERL---QGTH 261
MHRD+K +NIL+ NG +K+ DFGVS Q+ ++A SF+GT +M+PE +
Sbjct: 131 GKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGG 190
Query: 262 YSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFEL 321
Y+ D+W++G++ +E+A + PP +F PM L
Sbjct: 191 YNQLCDLWAVGITAIELA----ELQPP-------MF--------------DLHPMRALFL 225
Query: 322 LDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
+ +PP +S+ F FV L KNP +R + L+ H ++
Sbjct: 226 MTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV 273
>AC007684-1|AAF19240.1| 712|Homo sapiens unknown protein.
Length = 712
Score = 128 bits (309), Expect = 3e-29
Identities = 89/288 (30%), Positives = 147/288 (51%), Gaps = 34/288 (11%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIR-ELKVLHECNFA 146
+DFE + +G G G V K R+ +TG + A K+I LE P +++ E+ ++ +C
Sbjct: 14 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLE--PGEDFAVVQQEIIMMKDCKHP 71
Query: 147 HIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKH 206
+IV ++G++ ++ ICME+ GGSL I G + E + ++ L+GL YL K
Sbjct: 72 NIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSK- 130
Query: 207 AIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPERL---QGTH 261
MHRD+K +NIL+ NG +K+ DFGVS Q+ ++A SF+GT +M+PE +
Sbjct: 131 GKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGG 190
Query: 262 YSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFEL 321
Y+ D+W++G++ +E+A + PP +F PM L
Sbjct: 191 YNQLCDLWAVGITAIELA----ELQPP-------MF--------------DLHPMRALFL 225
Query: 322 LDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
+ +PP +S+ F FV L KNP +R + L+ H ++
Sbjct: 226 MTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV 273
>AF172271-1|AAF03789.1| 1268|Homo sapiens Traf2 and NCK interacting
kinase, splice variant 8 protein.
Length = 1268
Score = 127 bits (307), Expect = 6e-29
Identities = 94/303 (31%), Positives = 155/303 (51%), Gaps = 47/303 (15%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE-CNFAHI 148
FE + +G G G V K RH TG + A K+ ++V +++I +E+ +L + + +I
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNI 82
Query: 149 VGFYGAFYS------DGEISICMEYMDGGSLDLILK--KAGRIPESILGTITSAVLKGLS 200
+YGAF D ++ + ME+ GS+ ++K K + E + I +L+GLS
Sbjct: 83 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLS 142
Query: 201 YLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPERL- 257
+L +H ++HRD+K N+L+ N E+K+ DFGVS QL ++ N+F+GT +M+PE +
Sbjct: 143 HLH-QHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 258 ----QGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSP 313
Y +SD+WSLG++ +EMA G P+ D + A+F
Sbjct: 202 CDENPDATYDFKSDLWSLGITAIEMAEGAPPL--CDMHPMRALF---------------- 243
Query: 314 RPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAE 373
I P P+L S +S +F+ F++ CL KN +R + LM H +IR
Sbjct: 244 ----------LIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQP 293
Query: 374 AEK 376
E+
Sbjct: 294 NER 296
>AF172270-1|AAF03788.1| 1297|Homo sapiens Traf2 and NCK interacting
kinase, splice variant 7 protein.
Length = 1297
Score = 127 bits (307), Expect = 6e-29
Identities = 94/303 (31%), Positives = 155/303 (51%), Gaps = 47/303 (15%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE-CNFAHI 148
FE + +G G G V K RH TG + A K+ ++V +++I +E+ +L + + +I
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNI 82
Query: 149 VGFYGAFYS------DGEISICMEYMDGGSLDLILK--KAGRIPESILGTITSAVLKGLS 200
+YGAF D ++ + ME+ GS+ ++K K + E + I +L+GLS
Sbjct: 83 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLS 142
Query: 201 YLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPERL- 257
+L +H ++HRD+K N+L+ N E+K+ DFGVS QL ++ N+F+GT +M+PE +
Sbjct: 143 HLH-QHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 258 ----QGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSP 313
Y +SD+WSLG++ +EMA G P+ D + A+F
Sbjct: 202 CDENPDATYDFKSDLWSLGITAIEMAEGAPPL--CDMHPMRALF---------------- 243
Query: 314 RPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAE 373
I P P+L S +S +F+ F++ CL KN +R + LM H +IR
Sbjct: 244 ----------LIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQP 293
Query: 374 AEK 376
E+
Sbjct: 294 NER 296
>AF172269-1|AAF03787.1| 1323|Homo sapiens Traf2 and NCK interacting
kinase, splice variant 6 protein.
Length = 1323
Score = 127 bits (307), Expect = 6e-29
Identities = 94/303 (31%), Positives = 155/303 (51%), Gaps = 47/303 (15%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE-CNFAHI 148
FE + +G G G V K RH TG + A K+ ++V +++I +E+ +L + + +I
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNI 82
Query: 149 VGFYGAFYS------DGEISICMEYMDGGSLDLILK--KAGRIPESILGTITSAVLKGLS 200
+YGAF D ++ + ME+ GS+ ++K K + E + I +L+GLS
Sbjct: 83 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLS 142
Query: 201 YLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPERL- 257
+L +H ++HRD+K N+L+ N E+K+ DFGVS QL ++ N+F+GT +M+PE +
Sbjct: 143 HLH-QHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 258 ----QGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSP 313
Y +SD+WSLG++ +EMA G P+ D + A+F
Sbjct: 202 CDENPDATYDFKSDLWSLGITAIEMAEGAPPL--CDMHPMRALF---------------- 243
Query: 314 RPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAE 373
I P P+L S +S +F+ F++ CL KN +R + LM H +IR
Sbjct: 244 ----------LIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQP 293
Query: 374 AEK 376
E+
Sbjct: 294 NER 296
>AF172268-1|AAF03786.1| 1276|Homo sapiens Traf2 and NCK interacting
kinase, splice variant 5 protein.
Length = 1276
Score = 127 bits (307), Expect = 6e-29
Identities = 94/303 (31%), Positives = 155/303 (51%), Gaps = 47/303 (15%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE-CNFAHI 148
FE + +G G G V K RH TG + A K+ ++V +++I +E+ +L + + +I
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNI 82
Query: 149 VGFYGAFYS------DGEISICMEYMDGGSLDLILK--KAGRIPESILGTITSAVLKGLS 200
+YGAF D ++ + ME+ GS+ ++K K + E + I +L+GLS
Sbjct: 83 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLS 142
Query: 201 YLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPERL- 257
+L +H ++HRD+K N+L+ N E+K+ DFGVS QL ++ N+F+GT +M+PE +
Sbjct: 143 HLH-QHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 258 ----QGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSP 313
Y +SD+WSLG++ +EMA G P+ D + A+F
Sbjct: 202 CDENPDATYDFKSDLWSLGITAIEMAEGAPPL--CDMHPMRALF---------------- 243
Query: 314 RPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAE 373
I P P+L S +S +F+ F++ CL KN +R + LM H +IR
Sbjct: 244 ----------LIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQP 293
Query: 374 AEK 376
E+
Sbjct: 294 NER 296
>AF172267-1|AAF03785.1| 1352|Homo sapiens Traf2 and NCK interacting
kinase, splice variant 4 protein.
Length = 1352
Score = 127 bits (307), Expect = 6e-29
Identities = 94/303 (31%), Positives = 155/303 (51%), Gaps = 47/303 (15%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE-CNFAHI 148
FE + +G G G V K RH TG + A K+ ++V +++I +E+ +L + + +I
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNI 82
Query: 149 VGFYGAFYS------DGEISICMEYMDGGSLDLILK--KAGRIPESILGTITSAVLKGLS 200
+YGAF D ++ + ME+ GS+ ++K K + E + I +L+GLS
Sbjct: 83 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLS 142
Query: 201 YLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPERL- 257
+L +H ++HRD+K N+L+ N E+K+ DFGVS QL ++ N+F+GT +M+PE +
Sbjct: 143 HLH-QHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 258 ----QGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSP 313
Y +SD+WSLG++ +EMA G P+ D + A+F
Sbjct: 202 CDENPDATYDFKSDLWSLGITAIEMAEGAPPL--CDMHPMRALF---------------- 243
Query: 314 RPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAE 373
I P P+L S +S +F+ F++ CL KN +R + LM H +IR
Sbjct: 244 ----------LIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQP 293
Query: 374 AEK 376
E+
Sbjct: 294 NER 296
>AF172266-1|AAF03784.1| 1305|Homo sapiens Traf2 and NCK interacting
kinase, splice variant 3 protein.
Length = 1305
Score = 127 bits (307), Expect = 6e-29
Identities = 94/303 (31%), Positives = 155/303 (51%), Gaps = 47/303 (15%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE-CNFAHI 148
FE + +G G G V K RH TG + A K+ ++V +++I +E+ +L + + +I
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNI 82
Query: 149 VGFYGAFYS------DGEISICMEYMDGGSLDLILK--KAGRIPESILGTITSAVLKGLS 200
+YGAF D ++ + ME+ GS+ ++K K + E + I +L+GLS
Sbjct: 83 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLS 142
Query: 201 YLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPERL- 257
+L +H ++HRD+K N+L+ N E+K+ DFGVS QL ++ N+F+GT +M+PE +
Sbjct: 143 HLH-QHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 258 ----QGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSP 313
Y +SD+WSLG++ +EMA G P+ D + A+F
Sbjct: 202 CDENPDATYDFKSDLWSLGITAIEMAEGAPPL--CDMHPMRALF---------------- 243
Query: 314 RPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAE 373
I P P+L S +S +F+ F++ CL KN +R + LM H +IR
Sbjct: 244 ----------LIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQP 293
Query: 374 AEK 376
E+
Sbjct: 294 NER 296
>AF172265-1|AAF03783.1| 1331|Homo sapiens Traf2 and NCK interacting
kinase, splice variant 2 protein.
Length = 1331
Score = 127 bits (307), Expect = 6e-29
Identities = 94/303 (31%), Positives = 155/303 (51%), Gaps = 47/303 (15%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE-CNFAHI 148
FE + +G G G V K RH TG + A K+ ++V +++I +E+ +L + + +I
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNI 82
Query: 149 VGFYGAFYS------DGEISICMEYMDGGSLDLILK--KAGRIPESILGTITSAVLKGLS 200
+YGAF D ++ + ME+ GS+ ++K K + E + I +L+GLS
Sbjct: 83 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLS 142
Query: 201 YLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPERL- 257
+L +H ++HRD+K N+L+ N E+K+ DFGVS QL ++ N+F+GT +M+PE +
Sbjct: 143 HLH-QHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 258 ----QGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSP 313
Y +SD+WSLG++ +EMA G P+ D + A+F
Sbjct: 202 CDENPDATYDFKSDLWSLGITAIEMAEGAPPL--CDMHPMRALF---------------- 243
Query: 314 RPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAE 373
I P P+L S +S +F+ F++ CL KN +R + LM H +IR
Sbjct: 244 ----------LIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQP 293
Query: 374 AEK 376
E+
Sbjct: 294 NER 296
>AF172264-1|AAF03782.1| 1360|Homo sapiens Traf2 and NCK interacting
kinase, splice variant 1 protein.
Length = 1360
Score = 127 bits (307), Expect = 6e-29
Identities = 94/303 (31%), Positives = 155/303 (51%), Gaps = 47/303 (15%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE-CNFAHI 148
FE + +G G G V K RH TG + A K+ ++V +++I +E+ +L + + +I
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNI 82
Query: 149 VGFYGAFYS------DGEISICMEYMDGGSLDLILK--KAGRIPESILGTITSAVLKGLS 200
+YGAF D ++ + ME+ GS+ ++K K + E + I +L+GLS
Sbjct: 83 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLS 142
Query: 201 YLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPERL- 257
+L +H ++HRD+K N+L+ N E+K+ DFGVS QL ++ N+F+GT +M+PE +
Sbjct: 143 HLH-QHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 258 ----QGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSP 313
Y +SD+WSLG++ +EMA G P+ D + A+F
Sbjct: 202 CDENPDATYDFKSDLWSLGITAIEMAEGAPPL--CDMHPMRALF---------------- 243
Query: 314 RPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAE 373
I P P+L S +S +F+ F++ CL KN +R + LM H +IR
Sbjct: 244 ----------LIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQP 293
Query: 374 AEK 376
E+
Sbjct: 294 NER 296
>AB011123-1|BAA25477.2| 1385|Homo sapiens KIAA0551 protein protein.
Length = 1385
Score = 127 bits (307), Expect = 6e-29
Identities = 94/303 (31%), Positives = 155/303 (51%), Gaps = 47/303 (15%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE-CNFAHI 148
FE + +G G G V K RH TG + A K+ ++V +++I +E+ +L + + +I
Sbjct: 50 FELVELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNI 107
Query: 149 VGFYGAFYS------DGEISICMEYMDGGSLDLILK--KAGRIPESILGTITSAVLKGLS 200
+YGAF D ++ + ME+ GS+ ++K K + E + I +L+GLS
Sbjct: 108 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLS 167
Query: 201 YLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPERL- 257
+L +H ++HRD+K N+L+ N E+K+ DFGVS QL ++ N+F+GT +M+PE +
Sbjct: 168 HLH-QHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 226
Query: 258 ----QGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSP 313
Y +SD+WSLG++ +EMA G P+ D + A+F
Sbjct: 227 CDENPDATYDFKSDLWSLGITAIEMAEGAPPL--CDMHPMRALF---------------- 268
Query: 314 RPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAE 373
I P P+L S +S +F+ F++ CL KN +R + LM H +IR
Sbjct: 269 ----------LIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQP 318
Query: 374 AEK 376
E+
Sbjct: 319 NER 321
>U77129-1|AAB48435.1| 846|Homo sapiens KHS1 protein.
Length = 846
Score = 126 bits (305), Expect = 1e-28
Identities = 80/254 (31%), Positives = 137/254 (53%), Gaps = 12/254 (4%)
Query: 89 DFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIR-ELKVLHECNFAH 147
D+E + +G G G V K R+ TG + A K+I LE P +I+ E+ ++ EC +
Sbjct: 19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE--PGDDFSLIQQEIFMVKECKHCN 76
Query: 148 IVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHA 207
IV ++G++ S ++ ICMEY GGSL I G + E + + L+GL+YL K
Sbjct: 77 IVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTK-G 135
Query: 208 IMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPERL---QGTHY 262
MHRD+K +NIL+ +G++K+ DFGV+ ++ ++A SF+GT +M+PE + Y
Sbjct: 136 KMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGY 195
Query: 263 SVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIF-EL 321
+ DIW++G++ +E +G P D + A+F + P + + + + F
Sbjct: 196 NQLCDIWAVGITAIE--LGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNF 253
Query: 322 LDYIVNEPPPKLPS 335
+ + + P K P+
Sbjct: 254 VKIALTKNPKKRPT 267
>BC036013-1|AAH36013.1| 846|Homo sapiens mitogen-activated protein
kinase kinase kinase kinase 5 protein.
Length = 846
Score = 126 bits (305), Expect = 1e-28
Identities = 80/254 (31%), Positives = 137/254 (53%), Gaps = 12/254 (4%)
Query: 89 DFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIR-ELKVLHECNFAH 147
D+E + +G G G V K R+ TG + A K+I LE P +I+ E+ ++ EC +
Sbjct: 19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE--PGDDFSLIQQEIFMVKECKHCN 76
Query: 148 IVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHA 207
IV ++G++ S ++ ICMEY GGSL I G + E + + L+GL+YL K
Sbjct: 77 IVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTK-G 135
Query: 208 IMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPERL---QGTHY 262
MHRD+K +NIL+ +G++K+ DFGV+ ++ ++A SF+GT +M+PE + Y
Sbjct: 136 KMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGY 195
Query: 263 SVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIF-EL 321
+ DIW++G++ +E +G P D + A+F + P + + + + F
Sbjct: 196 NQLCDIWAVGITAIE--LGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNF 253
Query: 322 LDYIVNEPPPKLPS 335
+ + + P K P+
Sbjct: 254 VKIALTKNPKKRPT 267
>AY847283-1|AAW31760.1| 379|Homo sapiens cyclin-dependent
kinase-like 4 protein.
Length = 379
Score = 126 bits (305), Expect = 1e-28
Identities = 89/294 (30%), Positives = 148/294 (50%), Gaps = 23/294 (7%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMA-RKLIHLEVKPAIKKQIIRELKVLHECNFA 146
+ +EKL + G+G+ GVV K R+K++G ++A +K + E P +KK +RE+++L +
Sbjct: 2 EKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKHP 61
Query: 147 HIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKH 206
++V F ++ + EY D L+ + + + + ++ ++ L+ L++ H
Sbjct: 62 NLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHI-H 120
Query: 207 AIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMA-NSFVGTRSYMSPERLQG-THYSV 264
+HRD+KP NIL+ G IKICDFG + LI A +V TR Y +PE L G T Y
Sbjct: 121 NCIHRDIKPENILITKQGIIKICDFGFAQILIPGDAYTDYVATRWYRAPELLVGDTQYGS 180
Query: 265 QSDIWSLGLSLVEMAIGMYPIPP--PDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELL 322
DIW++G E+ G P+ P D L I + G+ PR +IF+
Sbjct: 181 SVDIWAIGCVFAELLTGQ-PLWPGKSDVDQLYLII------RTLGKL--IPRHQSIFKSN 231
Query: 323 DYI--VNEPPPKLPSGI---FSDEFK---DFVDRCLKKNPDERADLKTLMNHEW 368
+ ++ P P+ + FSD +F+ CLK NPD+R L+ +
Sbjct: 232 GFFHGISIPEPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSY 285
>AY845084-1|AAW30008.1| 315|Homo sapiens cyclin-dependent
kinase-like 4 protein.
Length = 315
Score = 126 bits (305), Expect = 1e-28
Identities = 89/294 (30%), Positives = 148/294 (50%), Gaps = 23/294 (7%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMA-RKLIHLEVKPAIKKQIIRELKVLHECNFA 146
+ +EKL + G+G+ GVV K R+K++G ++A +K + E P +KK +RE+++L +
Sbjct: 2 EKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKHP 61
Query: 147 HIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKH 206
++V F ++ + EY D L+ + + + + ++ ++ L+ L++ H
Sbjct: 62 NLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHI-H 120
Query: 207 AIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMA-NSFVGTRSYMSPERLQG-THYSV 264
+HRD+KP NIL+ G IKICDFG + LI A +V TR Y +PE L G T Y
Sbjct: 121 NCIHRDIKPENILITKQGIIKICDFGFAQILIPGDAYTDYVATRWYRAPELLVGDTQYGS 180
Query: 265 QSDIWSLGLSLVEMAIGMYPIPP--PDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELL 322
DIW++G E+ G P+ P D L I + G+ PR +IF+
Sbjct: 181 SVDIWAIGCVFAELLTGQ-PLWPGKSDVDQLYLII------RTLGKL--IPRHQSIFKSN 231
Query: 323 DYI--VNEPPPKLPSGI---FSDEFK---DFVDRCLKKNPDERADLKTLMNHEW 368
+ ++ P P+ + FSD +F+ CLK NPD+R L+ +
Sbjct: 232 GFFHGISIPEPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSY 285
>AK075107-1|BAC11406.1| 339|Homo sapiens protein ( Homo sapiens
cDNA FLJ90626 fis, clone PLACE1003135, weakly similar to
SPORULATION-SPECIFIC PROTEIN 1 (EC 2.7.1.-). ).
Length = 339
Score = 126 bits (304), Expect = 1e-28
Identities = 82/212 (38%), Positives = 120/212 (56%), Gaps = 35/212 (16%)
Query: 163 ICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVKPSNILVN 221
I MEY+ GGS LDL+ +AG E + T+ +LKGL YL + I HRD+K +N+L++
Sbjct: 20 IIMEYLGGGSALDLL--RAGPFDEFQIATMLKEILKGLDYLHSEKKI-HRDIKAANVLLS 76
Query: 222 SNGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMA 279
G++K+ DFGV+GQL D+ N+FVGT +M+PE +Q + Y ++DIWSLG++ +E+A
Sbjct: 77 EQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELA 136
Query: 280 IGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIVNEPPPKLPSGIFS 339
G PP N D PM + L+ N PP + G F+
Sbjct: 137 KG----EPP------------NSD---------MHPMRVLFLIP--KNNPPTLV--GDFT 167
Query: 340 DEFKDFVDRCLKKNPDERADLKTLMNHEWIRK 371
FK+F+D CL K+P R K L+ H++I K
Sbjct: 168 KSFKEFIDACLNKDPSFRPTAKELLKHKFIVK 199
>X66358-1|CAA47002.1| 358|Homo sapiens serine/threonine protein
kinase protein.
Length = 358
Score = 125 bits (302), Expect = 2e-28
Identities = 70/204 (34%), Positives = 113/204 (55%), Gaps = 6/204 (2%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMA-RKLIHLEVKPAIKKQIIRELKVLHECNFA 146
+ +EK+G++G+G+ GVV K R++ TG I+A +K + E P IKK +RE+++L +
Sbjct: 3 EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHP 62
Query: 147 HIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKH 206
++V F + + EY D L + + +PE ++ +IT L+ +++ KH
Sbjct: 63 NLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCH-KH 121
Query: 207 AIMHRDVKPSNILVNSNGEIKICDFGVSGQLI--DSMANSFVGTRSYMSPERLQG-THYS 263
+HRDVKP NIL+ + IK+CDFG + L +V TR Y SPE L G T Y
Sbjct: 122 NCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQYG 181
Query: 264 VQSDIWSLGLSLVEMAIGMYPIPP 287
D+W++G E+ G+ P+ P
Sbjct: 182 PPVDVWAIGCVFAELLSGV-PLWP 204
>BC104977-1|AAI04978.1| 358|Homo sapiens cyclin-dependent
kinase-like 1 (CDC2-related kinase) protein.
Length = 358
Score = 125 bits (302), Expect = 2e-28
Identities = 70/204 (34%), Positives = 113/204 (55%), Gaps = 6/204 (2%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMA-RKLIHLEVKPAIKKQIIRELKVLHECNFA 146
+ +EK+G++G+G+ GVV K R++ TG I+A +K + E P IKK +RE+++L +
Sbjct: 3 EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHP 62
Query: 147 HIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKH 206
++V F + + EY D L + + +PE ++ +IT L+ +++ KH
Sbjct: 63 NLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCH-KH 121
Query: 207 AIMHRDVKPSNILVNSNGEIKICDFGVSGQLI--DSMANSFVGTRSYMSPERLQG-THYS 263
+HRDVKP NIL+ + IK+CDFG + L +V TR Y SPE L G T Y
Sbjct: 122 NCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQYG 181
Query: 264 VQSDIWSLGLSLVEMAIGMYPIPP 287
D+W++G E+ G+ P+ P
Sbjct: 182 PPVDVWAIGCVFAELLSGV-PLWP 204
>AY525548-1|AAS00095.1| 358|Homo sapiens cyclin-dependent
kinase-like 1 (CDC2-related kinase) protein.
Length = 358
Score = 125 bits (302), Expect = 2e-28
Identities = 70/204 (34%), Positives = 113/204 (55%), Gaps = 6/204 (2%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMA-RKLIHLEVKPAIKKQIIRELKVLHECNFA 146
+ +EK+G++G+G+ GVV K R++ TG I+A +K + E P IKK +RE+++L +
Sbjct: 3 EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHP 62
Query: 147 HIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKH 206
++V F + + EY D L + + +PE ++ +IT L+ +++ KH
Sbjct: 63 NLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCH-KH 121
Query: 207 AIMHRDVKPSNILVNSNGEIKICDFGVSGQLI--DSMANSFVGTRSYMSPERLQG-THYS 263
+HRDVKP NIL+ + IK+CDFG + L +V TR Y SPE L G T Y
Sbjct: 122 NCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQYG 181
Query: 264 VQSDIWSLGLSLVEMAIGMYPIPP 287
D+W++G E+ G+ P+ P
Sbjct: 182 PPVDVWAIGCVFAELLSGV-PLWP 204
>AF344883-1|AAK29621.1| 354|Homo sapiens serine/threonine protein
kinase MST4a protein.
Length = 354
Score = 125 bits (302), Expect = 2e-28
Identities = 68/176 (38%), Positives = 109/176 (61%), Gaps = 6/176 (3%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
F KL +G+G+ G V K T ++A K+I LE + I +E+ VL +C+ +++
Sbjct: 24 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVT 83
Query: 150 GFYGAFYSDGEISICMEYMDGGS-LDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
+YG++ ++ I MEY+ GGS LDL+ +AG E + T+ +LKGL YL + I
Sbjct: 84 KYYGSYLKGSKLWIIMEYLGGGSALDLL--RAGPFDEFQIATMLKEILKGLDYLHSEKKI 141
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHY 262
HRD+K +N+L++ G++K+ DFGV+GQL D+ N+FVGT +M+PE +Q + Y
Sbjct: 142 -HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAY 196
>BC034673-1|AAH34673.1| 1332|Homo sapiens misshapen-like kinase 1
(zebrafish) protein.
Length = 1332
Score = 124 bits (299), Expect = 6e-28
Identities = 94/303 (31%), Positives = 153/303 (50%), Gaps = 47/303 (15%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE-CNFAHI 148
FE + +G G G V K RH TG + A K+ ++V +++I +E+ +L + + +I
Sbjct: 25 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTEDEEEEIKQEINMLKKYSHHRNI 82
Query: 149 VGFYGAFY------SDGEISICMEYMDGGSLDLILK--KAGRIPESILGTITSAVLKGLS 200
+YGAF +D ++ + ME+ GS+ ++K K + E + I +L+GL+
Sbjct: 83 ATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLA 142
Query: 201 YLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPERL- 257
+L H ++HRD+K N+L+ N E+K+ DFGVS QL ++ N+F+GT +M+PE +
Sbjct: 143 HLH-AHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 258 ----QGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSP 313
Y +SDIWSLG++ +EMA G P+ D + A+F
Sbjct: 202 CDENPDATYDYRSDIWSLGITAIEMAEGAPPL--CDMHPMRALF---------------- 243
Query: 314 RPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAE 373
I PPP+L S +S +F DF+D CL K R + L+ +IR
Sbjct: 244 ----------LIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQP 293
Query: 374 AEK 376
E+
Sbjct: 294 TER 296
>AY775058-1|AAV41830.1| 1312|Homo sapiens misshapen/NIKs-related
kinase isoform beta protein.
Length = 1312
Score = 124 bits (299), Expect = 6e-28
Identities = 94/303 (31%), Positives = 153/303 (50%), Gaps = 47/303 (15%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE-CNFAHI 148
FE + +G G G V K RH TG + A K+ ++V +++I +E+ +L + + +I
Sbjct: 25 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTEDEEEEIKQEINMLKKYSHHRNI 82
Query: 149 VGFYGAFY------SDGEISICMEYMDGGSLDLILK--KAGRIPESILGTITSAVLKGLS 200
+YGAF +D ++ + ME+ GS+ ++K K + E + I +L+GL+
Sbjct: 83 ATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLA 142
Query: 201 YLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPERL- 257
+L H ++HRD+K N+L+ N E+K+ DFGVS QL ++ N+F+GT +M+PE +
Sbjct: 143 HLH-AHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 258 ----QGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSP 313
Y +SDIWSLG++ +EMA G P+ D + A+F
Sbjct: 202 CDENPDATYDYRSDIWSLGITAIEMAEGAPPL--CDMHPMRALF---------------- 243
Query: 314 RPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAE 373
I PPP+L S +S +F DF+D CL K R + L+ +IR
Sbjct: 244 ----------LIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQP 293
Query: 374 AEK 376
E+
Sbjct: 294 TER 296
>AB041926-1|BAA94838.1| 1303|Homo sapiens GCK family kinase MINK-2
protein.
Length = 1303
Score = 124 bits (299), Expect = 6e-28
Identities = 94/303 (31%), Positives = 153/303 (50%), Gaps = 47/303 (15%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE-CNFAHI 148
FE + +G G G V K RH TG + A K+ ++V +++I +E+ +L + + +I
Sbjct: 25 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTEDEEEEIKQEINMLKKYSHHRNI 82
Query: 149 VGFYGAFY------SDGEISICMEYMDGGSLDLILK--KAGRIPESILGTITSAVLKGLS 200
+YGAF +D ++ + ME+ GS+ ++K K + E + I +L+GL+
Sbjct: 83 ATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLA 142
Query: 201 YLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPERL- 257
+L H ++HRD+K N+L+ N E+K+ DFGVS QL ++ N+F+GT +M+PE +
Sbjct: 143 HLH-AHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 258 ----QGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSP 313
Y +SDIWSLG++ +EMA G P+ D + A+F
Sbjct: 202 CDENPDATYDYRSDIWSLGITAIEMAEGAPPL--CDMHPMRALF---------------- 243
Query: 314 RPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAE 373
I PPP+L S +S +F DF+D CL K R + L+ +IR
Sbjct: 244 ----------LIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQP 293
Query: 374 AEK 376
E+
Sbjct: 294 TER 296
>AB035698-1|BAA90753.1| 1295|Homo sapiens Misshapen/NIK-related
kinase MINK-1 protein.
Length = 1295
Score = 124 bits (299), Expect = 6e-28
Identities = 94/303 (31%), Positives = 153/303 (50%), Gaps = 47/303 (15%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE-CNFAHI 148
FE + +G G G V K RH TG + A K+ ++V +++I +E+ +L + + +I
Sbjct: 25 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTEDEEEEIKQEINMLKKYSHHRNI 82
Query: 149 VGFYGAFY------SDGEISICMEYMDGGSLDLILK--KAGRIPESILGTITSAVLKGLS 200
+YGAF +D ++ + ME+ GS+ ++K K + E + I +L+GL+
Sbjct: 83 ATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLA 142
Query: 201 YLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPERL- 257
+L H ++HRD+K N+L+ N E+K+ DFGVS QL ++ N+F+GT +M+PE +
Sbjct: 143 HLH-AHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 258 ----QGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSP 313
Y +SDIWSLG++ +EMA G P+ D + A+F
Sbjct: 202 CDENPDATYDYRSDIWSLGITAIEMAEGAPPL--CDMHPMRALF---------------- 243
Query: 314 RPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAE 373
I PPP+L S +S +F DF+D CL K R + L+ +IR
Sbjct: 244 ----------LIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQP 293
Query: 374 AEK 376
E+
Sbjct: 294 TER 296
>Z92542-3|CAI42485.1| 1030|Homo sapiens cyclin-dependent kinase-like
5 protein.
Length = 1030
Score = 122 bits (294), Expect = 2e-27
Identities = 91/289 (31%), Positives = 147/289 (50%), Gaps = 19/289 (6%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMA-RKLIHLEVKPAIKKQIIRELKVLHECNFAHI 148
FE LG +G+G GVV+K RHK T I+A +K E +K+ +RELK+L +I
Sbjct: 13 FEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENI 72
Query: 149 VGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
V AF G++ + EY++ L+L+ + +P + + ++K + + K+ I
Sbjct: 73 VELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCH-KNDI 131
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLID-SMAN--SFVGTRSYMSPERLQGTHYSVQ 265
+HRD+KP N+L++ N +K+CDFG + L + + AN +V TR Y SPE L G Y
Sbjct: 132 VHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKS 191
Query: 266 SDIWSLGLSLVEMAIGMYPIPPPDAK-----TLAAIFGGQNEDHSPGQAPNSPRPMAIFE 320
D+WS+G L E++ G P+ P +++ T+ + G + N PR F
Sbjct: 192 VDMWSVGCILGELSDGQ-PLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSN-PR----FH 245
Query: 321 LLDY-IVNEPP--PKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNH 366
L + VN P + GI + D + LK +P +R + +NH
Sbjct: 246 GLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNH 294
>Y15057-1|CAA75342.1| 1030|Homo sapiens STK9 protein protein.
Length = 1030
Score = 122 bits (294), Expect = 2e-27
Identities = 91/289 (31%), Positives = 147/289 (50%), Gaps = 19/289 (6%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMA-RKLIHLEVKPAIKKQIIRELKVLHECNFAHI 148
FE LG +G+G GVV+K RHK T I+A +K E +K+ +RELK+L +I
Sbjct: 13 FEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENI 72
Query: 149 VGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
V AF G++ + EY++ L+L+ + +P + + ++K + + K+ I
Sbjct: 73 VELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCH-KNDI 131
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLID-SMAN--SFVGTRSYMSPERLQGTHYSVQ 265
+HRD+KP N+L++ N +K+CDFG + L + + AN +V TR Y SPE L G Y
Sbjct: 132 VHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKS 191
Query: 266 SDIWSLGLSLVEMAIGMYPIPPPDAK-----TLAAIFGGQNEDHSPGQAPNSPRPMAIFE 320
D+WS+G L E++ G P+ P +++ T+ + G + N PR F
Sbjct: 192 VDMWSVGCILGELSDGQ-PLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSN-PR----FH 245
Query: 321 LLDY-IVNEPP--PKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNH 366
L + VN P + GI + D + LK +P +R + +NH
Sbjct: 246 GLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNH 294
>BC047865-1|AAH47865.1| 812|Homo sapiens MAP4K2 protein protein.
Length = 812
Score = 122 bits (294), Expect = 2e-27
Identities = 68/196 (34%), Positives = 110/196 (56%), Gaps = 7/196 (3%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAH 147
D FE L +G G G V K R T + A K++ L+ I + +E+ +L EC +
Sbjct: 14 DRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISS-LQQEITILRECRHPN 72
Query: 148 IVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHA 207
+V + G++ + + ICME+ GGSL I G + E + + LKGL +L +
Sbjct: 73 VVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHHLHSQGK 132
Query: 208 IMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPERL---QGTHY 262
I HRD+K +N+L+ G++K+ DFGVSG+L S+A SF+GT +M+PE + Y
Sbjct: 133 I-HRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGY 191
Query: 263 SVQSDIWSLGLSLVEM 278
+ D+W+LG++ +E+
Sbjct: 192 NELCDVWALGITAIEL 207
>AY217744-1|AAO64440.1| 1030|Homo sapiens serine/threonine kinase 9
protein.
Length = 1030
Score = 122 bits (294), Expect = 2e-27
Identities = 91/289 (31%), Positives = 147/289 (50%), Gaps = 19/289 (6%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMA-RKLIHLEVKPAIKKQIIRELKVLHECNFAHI 148
FE LG +G+G GVV+K RHK T I+A +K E +K+ +RELK+L +I
Sbjct: 13 FEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENI 72
Query: 149 VGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
V AF G++ + EY++ L+L+ + +P + + ++K + + K+ I
Sbjct: 73 VELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCH-KNDI 131
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLID-SMAN--SFVGTRSYMSPERLQGTHYSVQ 265
+HRD+KP N+L++ N +K+CDFG + L + + AN +V TR Y SPE L G Y
Sbjct: 132 VHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKS 191
Query: 266 SDIWSLGLSLVEMAIGMYPIPPPDAK-----TLAAIFGGQNEDHSPGQAPNSPRPMAIFE 320
D+WS+G L E++ G P+ P +++ T+ + G + N PR F
Sbjct: 192 VDMWSVGCILGELSDGQ-PLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSN-PR----FH 245
Query: 321 LLDY-IVNEPP--PKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNH 366
L + VN P + GI + D + LK +P +R + +NH
Sbjct: 246 GLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNH 294
>AY212247-1|AAO32626.1| 1239|Homo sapiens Ste20 group protein kinase
HGK protein.
Length = 1239
Score = 122 bits (294), Expect = 2e-27
Identities = 93/303 (30%), Positives = 152/303 (50%), Gaps = 47/303 (15%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE-CNFAHI 148
FE + +G G G V K RH TG + A K+ ++V +++I E+ +L + + +I
Sbjct: 25 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTEDEEEEIKLEINMLKKYSHHRNI 82
Query: 149 VGFYGAFYS------DGEISICMEYMDGGSLDLILK--KAGRIPESILGTITSAVLKGLS 200
+YGAF D ++ + ME+ GS+ ++K K + E + I+ +L+GL+
Sbjct: 83 ATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLA 142
Query: 201 YLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPERL- 257
+L H I HRD+K N+L+ N E+K+ DFGVS QL ++ N+F+GT +M+PE +
Sbjct: 143 HLHIHHVI-HRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 258 ----QGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSP 313
Y +SD+WS G++ +EMA G P+ D + A+F
Sbjct: 202 CDENPDATYDYRSDLWSCGITAIEMAEGAPPL--CDMHPMRALF---------------- 243
Query: 314 RPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAE 373
I PPP+L S +S +F F++ CL KN +R + L+ H +IR
Sbjct: 244 ----------LIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQP 293
Query: 374 AEK 376
E+
Sbjct: 294 NER 296
>AL109798-1|CAI41159.1| 1030|Homo sapiens cyclin-dependent
kinase-like 5 protein.
Length = 1030
Score = 122 bits (294), Expect = 2e-27
Identities = 91/289 (31%), Positives = 147/289 (50%), Gaps = 19/289 (6%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMA-RKLIHLEVKPAIKKQIIRELKVLHECNFAHI 148
FE LG +G+G GVV+K RHK T I+A +K E +K+ +RELK+L +I
Sbjct: 13 FEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENI 72
Query: 149 VGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAI 208
V AF G++ + EY++ L+L+ + +P + + ++K + + K+ I
Sbjct: 73 VELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCH-KNDI 131
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLID-SMAN--SFVGTRSYMSPERLQGTHYSVQ 265
+HRD+KP N+L++ N +K+CDFG + L + + AN +V TR Y SPE L G Y
Sbjct: 132 VHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKS 191
Query: 266 SDIWSLGLSLVEMAIGMYPIPPPDAK-----TLAAIFGGQNEDHSPGQAPNSPRPMAIFE 320
D+WS+G L E++ G P+ P +++ T+ + G + N PR F
Sbjct: 192 VDMWSVGCILGELSDGQ-PLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSN-PR----FH 245
Query: 321 LLDY-IVNEPP--PKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNH 366
L + VN P + GI + D + LK +P +R + +NH
Sbjct: 246 GLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNH 294
>AF096300-1|AAD16137.1| 1165|Homo sapiens HPK/GCK-like kinase HGK
protein.
Length = 1165
Score = 122 bits (294), Expect = 2e-27
Identities = 93/303 (30%), Positives = 152/303 (50%), Gaps = 47/303 (15%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE-CNFAHI 148
FE + +G G G V K RH TG + A K+ ++V +++I E+ +L + + +I
Sbjct: 25 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTEDEEEEIKLEINMLKKYSHHRNI 82
Query: 149 VGFYGAFYS------DGEISICMEYMDGGSLDLILK--KAGRIPESILGTITSAVLKGLS 200
+YGAF D ++ + ME+ GS+ ++K K + E + I+ +L+GL+
Sbjct: 83 ATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLA 142
Query: 201 YLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPERL- 257
+L H I HRD+K N+L+ N E+K+ DFGVS QL ++ N+F+GT +M+PE +
Sbjct: 143 HLHIHHVI-HRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 258 ----QGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSP 313
Y +SD+WS G++ +EMA G P+ D + A+F
Sbjct: 202 CDENPDATYDYRSDLWSCGITAIEMAEGAPPL--CDMHPMRALF---------------- 243
Query: 314 RPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAE 373
I PPP+L S +S +F F++ CL KN +R + L+ H +IR
Sbjct: 244 ----------LIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQP 293
Query: 374 AEK 376
E+
Sbjct: 294 NER 296
>U07349-1|AAA20968.1| 819|Homo sapiens GC kinase protein.
Length = 819
Score = 121 bits (291), Expect = 5e-27
Identities = 68/196 (34%), Positives = 110/196 (56%), Gaps = 7/196 (3%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAH 147
D FE L +G G G V K R T + A K++ L+ I + +E+ +L EC +
Sbjct: 13 DRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISS-LQQEITILRECRHPN 71
Query: 148 IVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHA 207
+V + G++ + + ICME+ GGSL I G + E + + LKGL +L +
Sbjct: 72 VVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCRERLKGLHHLHSQGK 131
Query: 208 IMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPERL---QGTHY 262
I HRD+K +N+L+ G++K+ DFGVSG+L S+A SF+GT +M+PE + Y
Sbjct: 132 I-HRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGY 190
Query: 263 SVQSDIWSLGLSLVEM 278
+ D+W+LG++ +E+
Sbjct: 191 NELCDVWALGITAIEL 206
>BC035596-1|AAH35596.1| 681|Homo sapiens PAK6 protein protein.
Length = 681
Score = 121 bits (291), Expect = 5e-27
Identities = 84/278 (30%), Positives = 147/278 (52%), Gaps = 34/278 (12%)
Query: 95 ELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIVGFYGA 154
++G+G+ G+V R K +G +A K++ L K ++ + E+ ++ + ++V Y +
Sbjct: 412 KIGEGSTGIVCLAREKHSGRQVAVKMMDLR-KQQRRELLFNEVVIMRDYQHFNVVEMYKS 470
Query: 155 FYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVK 214
+ E+ + ME++ GG+L I+ + R+ E + T+ AVL+ L+YL + ++HRD+K
Sbjct: 471 YLVGEELWVLMEFLQGGALTDIVSQV-RLNEEQIATVCEAVLQALAYLHAQ-GVIHRDIK 528
Query: 215 PSNILVNSNGEIKICDFGVSGQLIDSMAN--SFVGTRSYMSPERLQGTHYSVQSDIWSLG 272
+IL+ +G +K+ DFG Q+ + S VGT +M+PE + + Y+ + DIWSLG
Sbjct: 529 SDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLG 588
Query: 273 LSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIVNEPPPK 332
+ ++EM G PP F SP QA R + PPPK
Sbjct: 589 IMVIEMVDG----EPP-------YF-----SDSPVQAMKRLR------------DSPPPK 620
Query: 333 LP-SGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
L S S +DF++R L ++P ERA + L++H ++
Sbjct: 621 LKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFL 658
>AJ236915-1|CAC18720.1| 681|Homo sapiens pak5 protein protein.
Length = 681
Score = 121 bits (291), Expect = 5e-27
Identities = 84/278 (30%), Positives = 147/278 (52%), Gaps = 34/278 (12%)
Query: 95 ELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIVGFYGA 154
++G+G+ G+V R K +G +A K++ L K ++ + E+ ++ + ++V Y +
Sbjct: 412 KIGEGSTGIVCLAREKHSGRQVAVKMMDLR-KQQRRELLFNEVVIMRDYQHFNVVEMYKS 470
Query: 155 FYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVK 214
+ E+ + ME++ GG+L I+ + R+ E + T+ AVL+ L+YL + ++HRD+K
Sbjct: 471 YLVGEELWVLMEFLQGGALTDIVSQV-RLNEEQIATVCEAVLQALAYLHAQ-GVIHRDIK 528
Query: 215 PSNILVNSNGEIKICDFGVSGQLIDSMAN--SFVGTRSYMSPERLQGTHYSVQSDIWSLG 272
+IL+ +G +K+ DFG Q+ + S VGT +M+PE + + Y+ + DIWSLG
Sbjct: 529 SDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLG 588
Query: 273 LSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIVNEPPPK 332
+ ++EM G PP F SP QA R + PPPK
Sbjct: 589 IMVIEMVDG----EPP-------YF-----SDSPVQAMKRLR------------DSPPPK 620
Query: 333 LP-SGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
L S S +DF++R L ++P ERA + L++H ++
Sbjct: 621 LKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFL 658
>AF276893-1|AAF82800.1| 681|Homo sapiens p21-activated protein
kinase 6 protein.
Length = 681
Score = 121 bits (291), Expect = 5e-27
Identities = 84/278 (30%), Positives = 147/278 (52%), Gaps = 34/278 (12%)
Query: 95 ELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIVGFYGA 154
++G+G+ G+V R K +G +A K++ L K ++ + E+ ++ + ++V Y +
Sbjct: 412 KIGEGSTGIVCLAREKHSGRQVAVKMMDLR-KQQRRELLFNEVVIMRDYQHFNVVEMYKS 470
Query: 155 FYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVK 214
+ E+ + ME++ GG+L I+ + R+ E + T+ AVL+ L+YL + ++HRD+K
Sbjct: 471 YLVGEELWVLMEFLQGGALTDIVSQV-RLNEEQIATVCEAVLQALAYLHAQ-GVIHRDIK 528
Query: 215 PSNILVNSNGEIKICDFGVSGQLIDSMAN--SFVGTRSYMSPERLQGTHYSVQSDIWSLG 272
+IL+ +G +K+ DFG Q+ + S VGT +M+PE + + Y+ + DIWSLG
Sbjct: 529 SDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLG 588
Query: 273 LSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIVNEPPPK 332
+ ++EM G PP F SP QA R + PPPK
Sbjct: 589 IMVIEMVDG----EPP-------YF-----SDSPVQAMKRLR------------DSPPPK 620
Query: 333 LP-SGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
L S S +DF++R L ++P ERA + L++H ++
Sbjct: 621 LKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFL 658
>DQ201638-1|ABA27097.1| 527|Homo sapiens oxidative-stress
responsive 1 protein.
Length = 527
Score = 119 bits (287), Expect = 2e-26
Identities = 89/306 (29%), Positives = 152/306 (49%), Gaps = 39/306 (12%)
Query: 85 LSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECN 144
++ DD+E +G G VV +A K I+LE ++++E++ + +C+
Sbjct: 12 INRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCH 71
Query: 145 FAHIVGFYGAFYSDGEISICMEYMDGGSLDLILK--------KAGRIPESILGTITSAVL 196
+IV +Y +F E+ + M+ + GGS+ I+K K+G + ES + TI VL
Sbjct: 72 HPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVL 131
Query: 197 KGLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLI-------DSMANSFVGTR 249
+GL YL K+ +HRDVK NIL+ +G ++I DFGVS L + + +FVGT
Sbjct: 132 EGLEYLH-KNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTP 190
Query: 250 SYMSPERLQGTH-YSVQSDIWSLGLSLVEMAIGMYPIPP-PDAKTLAAIFGGQNEDHSPG 307
+M+PE ++ Y ++DIWS G++ +E+A G P P K L QN+
Sbjct: 191 CWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTL--QND----- 243
Query: 308 QAPNSPRPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHE 367
P+ + E+L + F+ + CL+K+P++R L+ H+
Sbjct: 244 -PPSLETGVQDKEMLKK-------------YGKSFRKMISLCLQKDPEKRPTAAELLRHK 289
Query: 368 WIRKAE 373
+ +KA+
Sbjct: 290 FFQKAK 295
>BC008726-1|AAH08726.1| 527|Homo sapiens oxidative-stress
responsive 1 protein.
Length = 527
Score = 119 bits (287), Expect = 2e-26
Identities = 89/306 (29%), Positives = 152/306 (49%), Gaps = 39/306 (12%)
Query: 85 LSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECN 144
++ DD+E +G G VV +A K I+LE ++++E++ + +C+
Sbjct: 12 INRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCH 71
Query: 145 FAHIVGFYGAFYSDGEISICMEYMDGGSLDLILK--------KAGRIPESILGTITSAVL 196
+IV +Y +F E+ + M+ + GGS+ I+K K+G + ES + TI VL
Sbjct: 72 HPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVL 131
Query: 197 KGLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLI-------DSMANSFVGTR 249
+GL YL K+ +HRDVK NIL+ +G ++I DFGVS L + + +FVGT
Sbjct: 132 EGLEYLH-KNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTP 190
Query: 250 SYMSPERLQGTH-YSVQSDIWSLGLSLVEMAIGMYPIPP-PDAKTLAAIFGGQNEDHSPG 307
+M+PE ++ Y ++DIWS G++ +E+A G P P K L QN+
Sbjct: 191 CWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTL--QND----- 243
Query: 308 QAPNSPRPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHE 367
P+ + E+L + F+ + CL+K+P++R L+ H+
Sbjct: 244 -PPSLETGVQDKEMLKK-------------YGKSFRKMISLCLQKDPEKRPTAAELLRHK 289
Query: 368 WIRKAE 373
+ +KA+
Sbjct: 290 FFQKAK 295
>AB017642-1|BAA75674.1| 527|Homo sapiens oxidative-stress
responsive 1 protein.
Length = 527
Score = 119 bits (287), Expect = 2e-26
Identities = 89/306 (29%), Positives = 152/306 (49%), Gaps = 39/306 (12%)
Query: 85 LSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECN 144
++ DD+E +G G VV +A K I+LE ++++E++ + +C+
Sbjct: 12 INRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCH 71
Query: 145 FAHIVGFYGAFYSDGEISICMEYMDGGSLDLILK--------KAGRIPESILGTITSAVL 196
+IV +Y +F E+ + M+ + GGS+ I+K K+G + ES + TI VL
Sbjct: 72 HPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVL 131
Query: 197 KGLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLI-------DSMANSFVGTR 249
+GL YL K+ +HRDVK NIL+ +G ++I DFGVS L + + +FVGT
Sbjct: 132 EGLEYLH-KNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTP 190
Query: 250 SYMSPERLQGTH-YSVQSDIWSLGLSLVEMAIGMYPIPP-PDAKTLAAIFGGQNEDHSPG 307
+M+PE ++ Y ++DIWS G++ +E+A G P P K L QN+
Sbjct: 191 CWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTL--QND----- 243
Query: 308 QAPNSPRPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHE 367
P+ + E+L + F+ + CL+K+P++R L+ H+
Sbjct: 244 -PPSLETGVQDKEMLKK-------------YGKSFRKMISLCLQKDPEKRPTAAELLRHK 289
Query: 368 WIRKAE 373
+ +KA+
Sbjct: 290 FFQKAK 295
>BC133039-1|AAI33040.1| 1001|Homo sapiens TAO kinase 1 protein.
Length = 1001
Score = 116 bits (280), Expect = 1e-25
Identities = 92/311 (29%), Positives = 148/311 (47%), Gaps = 37/311 (11%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKK--QIIRELKVLHECNFAH 147
F L E+G G+ G V R T ++A K + K + +K II+E+K L +
Sbjct: 28 FTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPN 87
Query: 148 IVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHA 207
+ + G + + + MEY G + DL+ + E + IT L+GL+YL H
Sbjct: 88 SIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHS-HT 146
Query: 208 IMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPE---RLQGTHYSV 264
++HRD+K NIL+ G++K+ DFG + + S ANSFVGT +M+PE + Y
Sbjct: 147 MIHRDIKAGNILLTEPGQVKLADFGSAS--MASPANSFVGTPYWMAPEVILAMDEGQYDG 204
Query: 265 QSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDY 324
+ D+WSLG++ +E+A P+ +A + A QNE SP N
Sbjct: 205 KVDVWSLGITCIELAERKPPLFNMNAMS-ALYHIAQNE--SPTLQSNE------------ 249
Query: 325 IVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVDIAGWVC 384
+SD F++FVD CL+K P +R + L+ H ++ + E V + +
Sbjct: 250 -------------WSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETV-LIDLIQ 295
Query: 385 KTMDLMPSTPN 395
+T D + N
Sbjct: 296 RTKDAVRELDN 306
>BC129951-1|AAI29952.1| 854|Homo sapiens MAP3K6 protein protein.
Length = 854
Score = 116 bits (280), Expect = 1e-25
Identities = 93/269 (34%), Positives = 137/269 (50%), Gaps = 19/269 (7%)
Query: 78 QKEKIGELSDDDFE--KLGE---LGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQ 132
+ E GE+ + D+E + GE LG+G GVV R + T + +A K I E +
Sbjct: 197 EAEGAGEMLEFDYEYTETGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIP-ERDSRFSQP 255
Query: 133 IIRELKVLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKA-GRIP--ESILG 189
+ E+ + +IV + G+ G + I ME + GGSL +L+ G + ES +
Sbjct: 256 LHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTIS 315
Query: 190 TITSAVLKGLSYLRDKHAIMHRDVKPSNILVNS-NGEIKICDFGVSGQL--IDSMANSFV 246
T +L+GL YL D H I+HRD+K N+L+N+ +G +KI DFG S +L I +F
Sbjct: 316 FYTRQILQGLGYLHDNH-IVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFT 374
Query: 247 GTRSYMSPERL-QGTH-YSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDH 304
GT YM+PE + QG Y +DIWSLG +++EMA G P + A G + H
Sbjct: 375 GTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVH 434
Query: 305 SPGQAPNSPRPMAIFELLDYIVNEPPPKL 333
P + S A F L + EP P+L
Sbjct: 435 PPMPSSLSAEAQA-FLLRTF---EPDPRL 459
>BC129950-1|AAI29951.1| 854|Homo sapiens MAP3K6 protein protein.
Length = 854
Score = 116 bits (280), Expect = 1e-25
Identities = 93/269 (34%), Positives = 137/269 (50%), Gaps = 19/269 (7%)
Query: 78 QKEKIGELSDDDFE--KLGE---LGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQ 132
+ E GE+ + D+E + GE LG+G GVV R + T + +A K I E +
Sbjct: 197 EAEGAGEMLEFDYEYTETGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIP-ERDSRFSQP 255
Query: 133 IIRELKVLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKA-GRIP--ESILG 189
+ E+ + +IV + G+ G + I ME + GGSL +L+ G + ES +
Sbjct: 256 LHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTIS 315
Query: 190 TITSAVLKGLSYLRDKHAIMHRDVKPSNILVNS-NGEIKICDFGVSGQL--IDSMANSFV 246
T +L+GL YL D H I+HRD+K N+L+N+ +G +KI DFG S +L I +F
Sbjct: 316 FYTRQILQGLGYLHDNH-IVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFT 374
Query: 247 GTRSYMSPERL-QGTH-YSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDH 304
GT YM+PE + QG Y +DIWSLG +++EMA G P + A G + H
Sbjct: 375 GTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVH 434
Query: 305 SPGQAPNSPRPMAIFELLDYIVNEPPPKL 333
P + S A F L + EP P+L
Sbjct: 435 PPMPSSLSAEAQA-FLLRTF---EPDPRL 459
>BC109032-1|AAI09033.1| 441|Homo sapiens MAP3K6 protein protein.
Length = 441
Score = 116 bits (280), Expect = 1e-25
Identities = 93/269 (34%), Positives = 137/269 (50%), Gaps = 19/269 (7%)
Query: 78 QKEKIGELSDDDFE--KLGE---LGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQ 132
+ E GE+ + D+E + GE LG+G GVV R + T + +A K I E +
Sbjct: 100 EAEGAGEMLEFDYEYTETGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIP-ERDSRFSQP 158
Query: 133 IIRELKVLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKA-GRIP--ESILG 189
+ E+ + +IV + G+ G + I ME + GGSL +L+ G + ES +
Sbjct: 159 LHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTIS 218
Query: 190 TITSAVLKGLSYLRDKHAIMHRDVKPSNILVNS-NGEIKICDFGVSGQL--IDSMANSFV 246
T +L+GL YL D H I+HRD+K N+L+N+ +G +KI DFG S +L I +F
Sbjct: 219 FYTRQILQGLGYLHDNH-IVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFT 277
Query: 247 GTRSYMSPERL-QGTH-YSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDH 304
GT YM+PE + QG Y +DIWSLG +++EMA G P + A G + H
Sbjct: 278 GTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVH 337
Query: 305 SPGQAPNSPRPMAIFELLDYIVNEPPPKL 333
P + S A F L + EP P+L
Sbjct: 338 PPMPSSLSAEAQA-FLLRTF---EPDPRL 362
>BC015914-1|AAH15914.1| 797|Homo sapiens MAP3K6 protein protein.
Length = 797
Score = 116 bits (280), Expect = 1e-25
Identities = 93/269 (34%), Positives = 137/269 (50%), Gaps = 19/269 (7%)
Query: 78 QKEKIGELSDDDFE--KLGE---LGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQ 132
+ E GE+ + D+E + GE LG+G GVV R + T + +A K I E +
Sbjct: 354 EAEGAGEMLEFDYEYTETGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIP-ERDSRFSQP 412
Query: 133 IIRELKVLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKA-GRIP--ESILG 189
+ E+ + +IV + G+ G + I ME + GGSL +L+ G + ES +
Sbjct: 413 LHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTIS 472
Query: 190 TITSAVLKGLSYLRDKHAIMHRDVKPSNILVNS-NGEIKICDFGVSGQL--IDSMANSFV 246
T +L+GL YL D H I+HRD+K N+L+N+ +G +KI DFG S +L I +F
Sbjct: 473 FYTRQILQGLGYLHDNH-IVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFT 531
Query: 247 GTRSYMSPERL-QGTH-YSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDH 304
GT YM+PE + QG Y +DIWSLG +++EMA G P + A G + H
Sbjct: 532 GTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVH 591
Query: 305 SPGQAPNSPRPMAIFELLDYIVNEPPPKL 333
P + S A F L + EP P+L
Sbjct: 592 PPMPSSLSAEAQA-FLLRTF---EPDPRL 616
>AY049015-1|AAL12217.1| 1001|Homo sapiens serine/threonine kinase
TAO1 protein.
Length = 1001
Score = 116 bits (280), Expect = 1e-25
Identities = 92/311 (29%), Positives = 148/311 (47%), Gaps = 37/311 (11%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKK--QIIRELKVLHECNFAH 147
F L E+G G+ G V R T ++A K + K + +K II+E+K L +
Sbjct: 28 FTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPN 87
Query: 148 IVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHA 207
+ + G + + + MEY G + DL+ + E + IT L+GL+YL H
Sbjct: 88 SIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHS-HT 146
Query: 208 IMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPE---RLQGTHYSV 264
++HRD+K NIL+ G++K+ DFG + + S ANSFVGT +M+PE + Y
Sbjct: 147 MIHRDIKAGNILLTEPGQVKLADFGSAS--MASPANSFVGTPYWMAPEVILAMDEGQYDG 204
Query: 265 QSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDY 324
+ D+WSLG++ +E+A P+ +A + A QNE SP N
Sbjct: 205 KVDVWSLGITCIELAERKPPLFNMNAMS-ALYHIAQNE--SPTLQSNE------------ 249
Query: 325 IVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVDIAGWVC 384
+SD F++FVD CL+K P +R + L+ H ++ + E V + +
Sbjct: 250 -------------WSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETV-LIDLIQ 295
Query: 385 KTMDLMPSTPN 395
+T D + N
Sbjct: 296 RTKDAVRELDN 306
>AL663123-5|CAI14778.1| 797|Homo sapiens mitogen-activated protein
kinase kinase kinase 6 protein.
Length = 797
Score = 116 bits (280), Expect = 1e-25
Identities = 93/269 (34%), Positives = 137/269 (50%), Gaps = 19/269 (7%)
Query: 78 QKEKIGELSDDDFE--KLGE---LGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQ 132
+ E GE+ + D+E + GE LG+G GVV R + T + +A K I E +
Sbjct: 354 EAEGAGEMLEFDYEYTETGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIP-ERDSRFSQP 412
Query: 133 IIRELKVLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKA-GRIP--ESILG 189
+ E+ + +IV + G+ G + I ME + GGSL +L+ G + ES +
Sbjct: 413 LHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTIS 472
Query: 190 TITSAVLKGLSYLRDKHAIMHRDVKPSNILVNS-NGEIKICDFGVSGQL--IDSMANSFV 246
T +L+GL YL D H I+HRD+K N+L+N+ +G +KI DFG S +L I +F
Sbjct: 473 FYTRQILQGLGYLHDNH-IVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFT 531
Query: 247 GTRSYMSPERL-QGTH-YSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDH 304
GT YM+PE + QG Y +DIWSLG +++EMA G P + A G + H
Sbjct: 532 GTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVH 591
Query: 305 SPGQAPNSPRPMAIFELLDYIVNEPPPKL 333
P + S A F L + EP P+L
Sbjct: 592 PPMPSSLSAEAQA-FLLRTF---EPDPRL 616
>AL663123-4|CAM12869.1| 1288|Homo sapiens mitogen-activated protein
kinase kinase kinase 6 protein.
Length = 1288
Score = 116 bits (280), Expect = 1e-25
Identities = 93/269 (34%), Positives = 137/269 (50%), Gaps = 19/269 (7%)
Query: 78 QKEKIGELSDDDFE--KLGE---LGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQ 132
+ E GE+ + D+E + GE LG+G GVV R + T + +A K I E +
Sbjct: 631 EAEGAGEMLEFDYEYTETGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIP-ERDSRFSQP 689
Query: 133 IIRELKVLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKA-GRIP--ESILG 189
+ E+ + +IV + G+ G + I ME + GGSL +L+ G + ES +
Sbjct: 690 LHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTIS 749
Query: 190 TITSAVLKGLSYLRDKHAIMHRDVKPSNILVNS-NGEIKICDFGVSGQL--IDSMANSFV 246
T +L+GL YL D H I+HRD+K N+L+N+ +G +KI DFG S +L I +F
Sbjct: 750 FYTRQILQGLGYLHDNH-IVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFT 808
Query: 247 GTRSYMSPERL-QGTH-YSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDH 304
GT YM+PE + QG Y +DIWSLG +++EMA G P + A G + H
Sbjct: 809 GTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVH 868
Query: 305 SPGQAPNSPRPMAIFELLDYIVNEPPPKL 333
P + S A F L + EP P+L
Sbjct: 869 PPMPSSLSAEAQA-FLLRTF---EPDPRL 893
>AF100318-1|AAD05304.1| 1011|Homo sapiens mitogen-activated protein
kinase kinase kinase 6 protein.
Length = 1011
Score = 116 bits (280), Expect = 1e-25
Identities = 93/269 (34%), Positives = 137/269 (50%), Gaps = 19/269 (7%)
Query: 78 QKEKIGELSDDDFE--KLGE---LGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQ 132
+ E GE+ + D+E + GE LG+G GVV R + T + +A K I E +
Sbjct: 354 EAEGAGEMLEFDYEYTETGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIP-ERDSRFSQP 412
Query: 133 IIRELKVLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKA-GRIP--ESILG 189
+ E+ + +IV + G+ G + I ME + GGSL +L+ G + ES +
Sbjct: 413 LHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTIS 472
Query: 190 TITSAVLKGLSYLRDKHAIMHRDVKPSNILVNS-NGEIKICDFGVSGQL--IDSMANSFV 246
T +L+GL YL D H I+HRD+K N+L+N+ +G +KI DFG S +L I +F
Sbjct: 473 FYTRQILQGLGYLHDNH-IVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFT 531
Query: 247 GTRSYMSPERL-QGTH-YSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDH 304
GT YM+PE + QG Y +DIWSLG +++EMA G P + A G + H
Sbjct: 532 GTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVH 591
Query: 305 SPGQAPNSPRPMAIFELLDYIVNEPPPKL 333
P + S A F L + EP P+L
Sbjct: 592 PPMPSSLSAEAQA-FLLRTF---EPDPRL 616
>AB208805-1|BAD92042.1| 1192|Homo sapiens mitogen-activated protein
kinase kinase kinase 6 variant protein.
Length = 1192
Score = 116 bits (280), Expect = 1e-25
Identities = 93/269 (34%), Positives = 137/269 (50%), Gaps = 19/269 (7%)
Query: 78 QKEKIGELSDDDFE--KLGE---LGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQ 132
+ E GE+ + D+E + GE LG+G GVV R + T + +A K I E +
Sbjct: 535 EAEGAGEMLEFDYEYTETGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIP-ERDSRFSQP 593
Query: 133 IIRELKVLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKA-GRIP--ESILG 189
+ E+ + +IV + G+ G + I ME + GGSL +L+ G + ES +
Sbjct: 594 LHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTIS 653
Query: 190 TITSAVLKGLSYLRDKHAIMHRDVKPSNILVNS-NGEIKICDFGVSGQL--IDSMANSFV 246
T +L+GL YL D H I+HRD+K N+L+N+ +G +KI DFG S +L I +F
Sbjct: 654 FYTRQILQGLGYLHDNH-IVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFT 712
Query: 247 GTRSYMSPERL-QGTH-YSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDH 304
GT YM+PE + QG Y +DIWSLG +++EMA G P + A G + H
Sbjct: 713 GTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVH 772
Query: 305 SPGQAPNSPRPMAIFELLDYIVNEPPPKL 333
P + S A F L + EP P+L
Sbjct: 773 PPMPSSLSAEAQA-FLLRTF---EPDPRL 797
>AB167411-1|BAD12485.1| 1288|Homo sapiens apoptosis
signal-regulating kinase 2 protein.
Length = 1288
Score = 116 bits (280), Expect = 1e-25
Identities = 93/269 (34%), Positives = 137/269 (50%), Gaps = 19/269 (7%)
Query: 78 QKEKIGELSDDDFE--KLGE---LGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQ 132
+ E GE+ + D+E + GE LG+G GVV R + T + +A K I E +
Sbjct: 631 EAEGAGEMLEFDYEYTETGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIP-ERDSRFSQP 689
Query: 133 IIRELKVLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKA-GRIP--ESILG 189
+ E+ + +IV + G+ G + I ME + GGSL +L+ G + ES +
Sbjct: 690 LHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTIS 749
Query: 190 TITSAVLKGLSYLRDKHAIMHRDVKPSNILVNS-NGEIKICDFGVSGQL--IDSMANSFV 246
T +L+GL YL D H I+HRD+K N+L+N+ +G +KI DFG S +L I +F
Sbjct: 750 FYTRQILQGLGYLHDNH-IVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFT 808
Query: 247 GTRSYMSPERL-QGTH-YSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDH 304
GT YM+PE + QG Y +DIWSLG +++EMA G P + A G + H
Sbjct: 809 GTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVH 868
Query: 305 SPGQAPNSPRPMAIFELLDYIVNEPPPKL 333
P + S A F L + EP P+L
Sbjct: 869 PPMPSSLSAEAQA-FLLRTF---EPDPRL 893
>AB037782-1|BAA92599.1| 1005|Homo sapiens KIAA1361 protein protein.
Length = 1005
Score = 116 bits (280), Expect = 1e-25
Identities = 92/311 (29%), Positives = 148/311 (47%), Gaps = 37/311 (11%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKK--QIIRELKVLHECNFAH 147
F L E+G G+ G V R T ++A K + K + +K II+E+K L +
Sbjct: 32 FTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPN 91
Query: 148 IVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHA 207
+ + G + + + MEY G + DL+ + E + IT L+GL+YL H
Sbjct: 92 SIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHS-HT 150
Query: 208 IMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPE---RLQGTHYSV 264
++HRD+K NIL+ G++K+ DFG + + S ANSFVGT +M+PE + Y
Sbjct: 151 MIHRDIKAGNILLTEPGQVKLADFGSAS--MASPANSFVGTPYWMAPEVILAMDEGQYDG 208
Query: 265 QSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDY 324
+ D+WSLG++ +E+A P+ +A + A QNE SP N
Sbjct: 209 KVDVWSLGITCIELAERKPPLFNMNAMS-ALYHIAQNE--SPTLQSNE------------ 253
Query: 325 IVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVDIAGWVC 384
+SD F++FVD CL+K P +R + L+ H ++ + E V + +
Sbjct: 254 -------------WSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETV-LIDLIQ 299
Query: 385 KTMDLMPSTPN 395
+T D + N
Sbjct: 300 RTKDAVRELDN 310
>BC026158-1|AAH26158.1| 1315|Homo sapiens serine/threonine kinase
36, fused homolog (Drosophila) protein.
Length = 1315
Score = 116 bits (279), Expect = 1e-25
Identities = 88/285 (30%), Positives = 142/285 (49%), Gaps = 35/285 (12%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLI-HLEVKPAIKKQIIRELKVLHECNFA 146
+ + L +G+G+ G V K R K + ++A K I L + + RE++++
Sbjct: 2 EKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHP 61
Query: 147 HIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKH 206
+IV +F +D E+ + +Y +G L IL+ G++PE + I + ++ L YL H
Sbjct: 62 NIVHMLDSFETDKEVVVVTDYAEG-ELFQILEDDGKLPEDQVQAIAAQLVSALYYLHS-H 119
Query: 207 AIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDS--MANSFVGTRSYMSPERLQGTHYSV 264
I+HRD+KP NIL+ G IK+CDFG + + + + S GT YMSPE ++ Y
Sbjct: 120 RILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDH 179
Query: 265 QSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDY 324
+D+WS+G L E+A+G PP T +IF+L+
Sbjct: 180 TADLWSVGCILYELAVGT----PPFYAT------------------------SIFQLVSL 211
Query: 325 IVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
I+ +P + PS I S FKDF+ L K+P +R L+ H +I
Sbjct: 212 ILKDPV-RWPSTI-SPCFKDFLQGLLTKDPRQRLSWPDLLYHPFI 254
>BC027464-1|AAH27464.1| 403|Homo sapiens aurora kinase A protein.
Length = 403
Score = 115 bits (277), Expect = 3e-25
Identities = 69/208 (33%), Positives = 107/208 (51%), Gaps = 8/208 (3%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLI---HLEVKPAIKKQIIRELKVLHECN 144
+DFE LG+G G V R K + I+A K++ LE K ++ Q+ RE+++
Sbjct: 131 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLE-KAGVEHQLRREVEIQSHLR 189
Query: 145 FAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRD 204
+I+ YG F+ + + +EY G++ L+K + E T + + LSY
Sbjct: 190 HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHS 249
Query: 205 KHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSV 264
K I HRD+KP N+L+ S GE+KI DFG S S + GT Y+ PE ++G +
Sbjct: 250 KRVI-HRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDE 308
Query: 265 QSDIWSLGLSLVEMAIGMYPIPPPDAKT 292
+ D+WSLG+ E +G PP +A T
Sbjct: 309 KVDLWSLGVLCYEFLVGK---PPFEANT 333
Score = 31.9 bits (69), Expect = 4.1
Identities = 11/27 (40%), Positives = 17/27 (62%)
Query: 343 KDFVDRCLKKNPDERADLKTLMNHEWI 369
+D + R LK NP +R L+ ++ H WI
Sbjct: 357 RDLISRLLKHNPSQRPMLREVLEHPWI 383
>BC006423-1|AAH06423.1| 403|Homo sapiens aurora kinase A protein.
Length = 403
Score = 115 bits (277), Expect = 3e-25
Identities = 69/208 (33%), Positives = 107/208 (51%), Gaps = 8/208 (3%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLI---HLEVKPAIKKQIIRELKVLHECN 144
+DFE LG+G G V R K + I+A K++ LE K ++ Q+ RE+++
Sbjct: 131 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLE-KAGVEHQLRREVEIQSHLR 189
Query: 145 FAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRD 204
+I+ YG F+ + + +EY G++ L+K + E T + + LSY
Sbjct: 190 HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHS 249
Query: 205 KHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSV 264
K I HRD+KP N+L+ S GE+KI DFG S S + GT Y+ PE ++G +
Sbjct: 250 KRVI-HRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDE 308
Query: 265 QSDIWSLGLSLVEMAIGMYPIPPPDAKT 292
+ D+WSLG+ E +G PP +A T
Sbjct: 309 KVDLWSLGVLCYEFLVGK---PPFEANT 333
Score = 31.9 bits (69), Expect = 4.1
Identities = 11/27 (40%), Positives = 17/27 (62%)
Query: 343 KDFVDRCLKKNPDERADLKTLMNHEWI 369
+D + R LK NP +R L+ ++ H WI
Sbjct: 357 RDLISRLLKHNPSQRPMLREVLEHPWI 383
>BC002499-1|AAH02499.1| 403|Homo sapiens AURKA protein protein.
Length = 403
Score = 115 bits (277), Expect = 3e-25
Identities = 69/208 (33%), Positives = 107/208 (51%), Gaps = 8/208 (3%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLI---HLEVKPAIKKQIIRELKVLHECN 144
+DFE LG+G G V R K + I+A K++ LE K ++ Q+ RE+++
Sbjct: 131 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLE-KAGVEHQLRREVEIQSHLR 189
Query: 145 FAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRD 204
+I+ YG F+ + + +EY G++ L+K + E T + + LSY
Sbjct: 190 HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHS 249
Query: 205 KHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSV 264
K I HRD+KP N+L+ S GE+KI DFG S S + GT Y+ PE ++G +
Sbjct: 250 KRVI-HRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDE 308
Query: 265 QSDIWSLGLSLVEMAIGMYPIPPPDAKT 292
+ D+WSLG+ E +G PP +A T
Sbjct: 309 KVDLWSLGVLCYEFLVGK---PPFEANT 333
Score = 31.9 bits (69), Expect = 4.1
Identities = 11/27 (40%), Positives = 17/27 (62%)
Query: 343 KDFVDRCLKKNPDERADLKTLMNHEWI 369
+D + R LK NP +R L+ ++ H WI
Sbjct: 357 RDLISRLLKHNPSQRPMLREVLEHPWI 383
>BC001280-1|AAH01280.1| 403|Homo sapiens aurora kinase A protein.
Length = 403
Score = 115 bits (277), Expect = 3e-25
Identities = 69/208 (33%), Positives = 107/208 (51%), Gaps = 8/208 (3%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLI---HLEVKPAIKKQIIRELKVLHECN 144
+DFE LG+G G V R K + I+A K++ LE K ++ Q+ RE+++
Sbjct: 131 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLE-KAGVEHQLRREVEIQSHLR 189
Query: 145 FAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRD 204
+I+ YG F+ + + +EY G++ L+K + E T + + LSY
Sbjct: 190 HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHS 249
Query: 205 KHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSV 264
K I HRD+KP N+L+ S GE+KI DFG S S + GT Y+ PE ++G +
Sbjct: 250 KRVI-HRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDE 308
Query: 265 QSDIWSLGLSLVEMAIGMYPIPPPDAKT 292
+ D+WSLG+ E +G PP +A T
Sbjct: 309 KVDLWSLGVLCYEFLVGK---PPFEANT 333
Score = 31.9 bits (69), Expect = 4.1
Identities = 11/27 (40%), Positives = 17/27 (62%)
Query: 343 KDFVDRCLKKNPDERADLKTLMNHEWI 369
+D + R LK NP +R L+ ++ H WI
Sbjct: 357 RDLISRLLKHNPSQRPMLREVLEHPWI 383
>AL121914-4|CAM45838.1| 347|Homo sapiens aurora kinase A protein.
Length = 347
Score = 115 bits (277), Expect = 3e-25
Identities = 69/208 (33%), Positives = 107/208 (51%), Gaps = 8/208 (3%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLI---HLEVKPAIKKQIIRELKVLHECN 144
+DFE LG+G G V R K + I+A K++ LE K ++ Q+ RE+++
Sbjct: 131 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLE-KAGVEHQLRREVEIQSHLR 189
Query: 145 FAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRD 204
+I+ YG F+ + + +EY G++ L+K + E T + + LSY
Sbjct: 190 HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHS 249
Query: 205 KHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSV 264
K I HRD+KP N+L+ S GE+KI DFG S S + GT Y+ PE ++G +
Sbjct: 250 KRVI-HRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDE 308
Query: 265 QSDIWSLGLSLVEMAIGMYPIPPPDAKT 292
+ D+WSLG+ E +G PP +A T
Sbjct: 309 KVDLWSLGVLCYEFLVGK---PPFEANT 333
>AL121914-3|CAC12717.1| 403|Homo sapiens aurora kinase A protein.
Length = 403
Score = 115 bits (277), Expect = 3e-25
Identities = 69/208 (33%), Positives = 107/208 (51%), Gaps = 8/208 (3%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLI---HLEVKPAIKKQIIRELKVLHECN 144
+DFE LG+G G V R K + I+A K++ LE K ++ Q+ RE+++
Sbjct: 131 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLE-KAGVEHQLRREVEIQSHLR 189
Query: 145 FAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRD 204
+I+ YG F+ + + +EY G++ L+K + E T + + LSY
Sbjct: 190 HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHS 249
Query: 205 KHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSV 264
K I HRD+KP N+L+ S GE+KI DFG S S + GT Y+ PE ++G +
Sbjct: 250 KRVI-HRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDE 308
Query: 265 QSDIWSLGLSLVEMAIGMYPIPPPDAKT 292
+ D+WSLG+ E +G PP +A T
Sbjct: 309 KVDLWSLGVLCYEFLVGK---PPFEANT 333
Score = 31.9 bits (69), Expect = 4.1
Identities = 11/27 (40%), Positives = 17/27 (62%)
Query: 343 KDFVDRCLKKNPDERADLKTLMNHEWI 369
+D + R LK NP +R L+ ++ H WI
Sbjct: 357 RDLISRLLKHNPSQRPMLREVLEHPWI 383
>AF195947-1|AAF29508.1| 403|Homo sapiens STK15 serine/threonine
kinase protein.
Length = 403
Score = 115 bits (277), Expect = 3e-25
Identities = 69/208 (33%), Positives = 107/208 (51%), Gaps = 8/208 (3%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLI---HLEVKPAIKKQIIRELKVLHECN 144
+DFE LG+G G V R K + I+A K++ LE K ++ Q+ RE+++
Sbjct: 131 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLE-KAGVEHQLRREVEIQSHLR 189
Query: 145 FAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRD 204
+I+ YG F+ + + +EY G++ L+K + E T + + LSY
Sbjct: 190 HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHS 249
Query: 205 KHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSV 264
K I HRD+KP N+L+ S GE+KI DFG S S + GT Y+ PE ++G +
Sbjct: 250 KRVI-HRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDE 308
Query: 265 QSDIWSLGLSLVEMAIGMYPIPPPDAKT 292
+ D+WSLG+ E +G PP +A T
Sbjct: 309 KVDLWSLGVLCYEFLVGK---PPFEANT 333
Score = 31.9 bits (69), Expect = 4.1
Identities = 11/27 (40%), Positives = 17/27 (62%)
Query: 343 KDFVDRCLKKNPDERADLKTLMNHEWI 369
+D + R LK NP +R L+ ++ H WI
Sbjct: 357 RDLISRLLKHNPSQRPMLREVLEHPWI 383
>AF011468-1|AAC63902.1| 403|Homo sapiens serine/threonine kinase
protein.
Length = 403
Score = 115 bits (277), Expect = 3e-25
Identities = 69/208 (33%), Positives = 107/208 (51%), Gaps = 8/208 (3%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLI---HLEVKPAIKKQIIRELKVLHECN 144
+DFE LG+G G V R K + I+A K++ LE K ++ Q+ RE+++
Sbjct: 131 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLE-KAGVEHQLRREVEIQSHLR 189
Query: 145 FAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRD 204
+I+ YG F+ + + +EY G++ L+K + E T + + LSY
Sbjct: 190 HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHS 249
Query: 205 KHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSV 264
K I HRD+KP N+L+ S GE+KI DFG S S + GT Y+ PE ++G +
Sbjct: 250 KRVI-HRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDE 308
Query: 265 QSDIWSLGLSLVEMAIGMYPIPPPDAKT 292
+ D+WSLG+ E +G PP +A T
Sbjct: 309 KVDLWSLGVLCYEFLVGK---PPFEANT 333
Score = 31.9 bits (69), Expect = 4.1
Identities = 11/27 (40%), Positives = 17/27 (62%)
Query: 343 KDFVDRCLKKNPDERADLKTLMNHEWI 369
+D + R LK NP +R L+ ++ H WI
Sbjct: 357 RDLISRLLKHNPSQRPMLREVLEHPWI 383
>AF008551-1|AAC12708.1| 403|Homo sapiens aurora-related kinase 1
protein.
Length = 403
Score = 115 bits (277), Expect = 3e-25
Identities = 69/208 (33%), Positives = 107/208 (51%), Gaps = 8/208 (3%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLI---HLEVKPAIKKQIIRELKVLHECN 144
+DFE LG+G G V R K + I+A K++ LE K ++ Q+ RE+++
Sbjct: 131 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLE-KAGVEHQLRREVEIQSHLR 189
Query: 145 FAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRD 204
+I+ YG F+ + + +EY G++ L+K + E T + + LSY
Sbjct: 190 HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHS 249
Query: 205 KHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSV 264
K I HRD+KP N+L+ S GE+KI DFG S S + GT Y+ PE ++G +
Sbjct: 250 KRVI-HRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDE 308
Query: 265 QSDIWSLGLSLVEMAIGMYPIPPPDAKT 292
+ D+WSLG+ E +G PP +A T
Sbjct: 309 KVDLWSLGVLCYEFLVGK---PPFEANT 333
Score = 31.9 bits (69), Expect = 4.1
Identities = 11/27 (40%), Positives = 17/27 (62%)
Query: 343 KDFVDRCLKKNPDERADLKTLMNHEWI 369
+D + R LK NP +R L+ ++ H WI
Sbjct: 357 RDLISRLLKHNPSQRPMLREVLEHPWI 383
>D84212-1|BAA23592.1| 402|Homo sapiens aurora/IPL1-related kinase
protein.
Length = 402
Score = 115 bits (276), Expect = 3e-25
Identities = 68/208 (32%), Positives = 107/208 (51%), Gaps = 8/208 (3%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLI---HLEVKPAIKKQIIRELKVLHECN 144
+DFE LG+G G V R K + I+A K++ LE K ++ Q+ RE+++
Sbjct: 130 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLE-KAGVEHQLRREVEIQSHLR 188
Query: 145 FAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRD 204
+I+ YG F+ + + +EY G++ L+K + E + + + LSY
Sbjct: 189 HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTANLYNRIANALSYCHS 248
Query: 205 KHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSV 264
K I HRD+KP N+L+ S GE+KI DFG S S + GT Y+ PE ++G +
Sbjct: 249 KRVI-HRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDE 307
Query: 265 QSDIWSLGLSLVEMAIGMYPIPPPDAKT 292
+ D+WSLG+ E +G PP +A T
Sbjct: 308 KVDLWSLGVLCYEFLVGK---PPFEANT 332
Score = 31.9 bits (69), Expect = 4.1
Identities = 11/27 (40%), Positives = 17/27 (62%)
Query: 343 KDFVDRCLKKNPDERADLKTLMNHEWI 369
+D + R LK NP +R L+ ++ H WI
Sbjct: 356 RDLISRLLKHNPSQRPMLREVLEHPWI 382
>M34182-1|AAC41690.1| 360|Homo sapiens protein kinase A
gamma-subunit protein.
Length = 360
Score = 114 bits (275), Expect = 5e-25
Identities = 64/201 (31%), Positives = 109/201 (54%), Gaps = 4/201 (1%)
Query: 86 SDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLE--VKPAIKKQIIRELKVLHEC 143
S D FE+L LG G+ G VM VRH+ TG A K+++ + VK + I+ E ++L
Sbjct: 49 SSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAI 108
Query: 144 NFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLR 203
+F +V +F + + + MEY+ GG + L++ GR E + V+ + YL
Sbjct: 109 DFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLH 168
Query: 204 DKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYS 263
++HRD+KP N+L++ G +++ DFG + + + + GT Y++PE + Y+
Sbjct: 169 SLD-LIHRDLKPENLLIDQQGYLQVTDFGFA-KRVKGRTWTLCGTPEYLAPEIILSKGYN 226
Query: 264 VQSDIWSLGLSLVEMAIGMYP 284
D W+LG+ + EMA+G P
Sbjct: 227 KAVDWWALGVLIYEMAVGFPP 247
>DQ667175-1|ABG25920.1| 351|Homo sapiens protein kinase,
cAMP-dependent, catalytic, gamma protein.
Length = 351
Score = 114 bits (275), Expect = 5e-25
Identities = 64/201 (31%), Positives = 109/201 (54%), Gaps = 4/201 (1%)
Query: 86 SDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLE--VKPAIKKQIIRELKVLHEC 143
S D FE+L LG G+ G VM VRH+ TG A K+++ + VK + I+ E ++L
Sbjct: 40 SSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAI 99
Query: 144 NFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLR 203
+F +V +F + + + MEY+ GG + L++ GR E + V+ + YL
Sbjct: 100 DFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLH 159
Query: 204 DKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYS 263
++HRD+KP N+L++ G +++ DFG + + + + GT Y++PE + Y+
Sbjct: 160 SLD-LIHRDLKPENLLIDQQGYLQVTDFGFA-KRVKGRTWTLCGTPEYLAPEIILSKGYN 217
Query: 264 VQSDIWSLGLSLVEMAIGMYP 284
D W+LG+ + EMA+G P
Sbjct: 218 KAVDWWALGVLIYEMAVGFPP 238
>BC125272-1|AAI25273.1| 625|Homo sapiens MYO3A protein protein.
Length = 625
Score = 114 bits (275), Expect = 5e-25
Identities = 95/308 (30%), Positives = 153/308 (49%), Gaps = 49/308 (15%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECN-FA 146
D +E +G+G G V KV +K G A K+ L+ I ++I E +L +
Sbjct: 19 DTWEITETIGKGTYGKVFKVLNKKNGQKAAVKI--LDPIHDIDEEIEAEYNILKALSDHP 76
Query: 147 HIVGFYGAFYSDGEIS-----ICMEYMDGGSL-DLI---LKKAGRIPESILGTITSAVLK 197
++V FYG ++ +++ + +E GGS+ DL+ LK+ R+ E ++ I L
Sbjct: 77 NVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALM 136
Query: 198 GLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDS--MANSFVGTRSYMSPE 255
GL +L + I HRDVK +NIL+ + G +K+ DFGVS QL + N+ VGT +M+PE
Sbjct: 137 GLQHLHNNKTI-HRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPE 195
Query: 256 RLQ-----GTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAP 310
+ T Y + D WSLG++ +E+ G P+ D + A+F
Sbjct: 196 VIACEQQLDTTYDARCDTWSLGITAIELGDGDPPL--ADLHPMRALF------------- 240
Query: 311 NSPRPMAIFELLDYIVNEPPPKL-PSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PR PPPKL ++S EF DF+ +CL K+ ++R + L+ H++I
Sbjct: 241 KIPR-------------NPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFI 287
Query: 370 RKAEAEKV 377
+ E + V
Sbjct: 288 TQIEGKDV 295
>BC119811-1|AAI19812.1| 664|Homo sapiens MYO3A protein protein.
Length = 664
Score = 114 bits (275), Expect = 5e-25
Identities = 95/308 (30%), Positives = 153/308 (49%), Gaps = 49/308 (15%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECN-FA 146
D +E +G+G G V KV +K G A K+ L+ I ++I E +L +
Sbjct: 19 DTWEITETIGKGTYGKVFKVLNKKNGQKAAVKI--LDPIHDIDEEIEAEYNILKALSDHP 76
Query: 147 HIVGFYGAFYSDGEIS-----ICMEYMDGGSL-DLI---LKKAGRIPESILGTITSAVLK 197
++V FYG ++ +++ + +E GGS+ DL+ LK+ R+ E ++ I L
Sbjct: 77 NVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALM 136
Query: 198 GLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDS--MANSFVGTRSYMSPE 255
GL +L + I HRDVK +NIL+ + G +K+ DFGVS QL + N+ VGT +M+PE
Sbjct: 137 GLQHLHNNKTI-HRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPE 195
Query: 256 RLQ-----GTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAP 310
+ T Y + D WSLG++ +E+ G P+ D + A+F
Sbjct: 196 VIACEQQLDTTYDARCDTWSLGITAIELGDGDPPL--ADLHPMRALF------------- 240
Query: 311 NSPRPMAIFELLDYIVNEPPPKL-PSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PR PPPKL ++S EF DF+ +CL K+ ++R + L+ H++I
Sbjct: 241 KIPR-------------NPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFI 287
Query: 370 RKAEAEKV 377
+ E + V
Sbjct: 288 TQIEGKDV 295
>BC039888-1|AAH39888.1| 351|Homo sapiens protein kinase,
cAMP-dependent, catalytic, gamma protein.
Length = 351
Score = 114 bits (275), Expect = 5e-25
Identities = 64/201 (31%), Positives = 109/201 (54%), Gaps = 4/201 (1%)
Query: 86 SDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLE--VKPAIKKQIIRELKVLHEC 143
S D FE+L LG G+ G VM VRH+ TG A K+++ + VK + I+ E ++L
Sbjct: 40 SSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAI 99
Query: 144 NFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLR 203
+F +V +F + + + MEY+ GG + L++ GR E + V+ + YL
Sbjct: 100 DFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLH 159
Query: 204 DKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYS 263
++HRD+KP N+L++ G +++ DFG + + + + GT Y++PE + Y+
Sbjct: 160 SLD-LIHRDLKPENLLIDQQGYLQVTDFGFA-KRVKGRTWTLCGTPEYLAPEIILSKGYN 217
Query: 264 VQSDIWSLGLSLVEMAIGMYP 284
D W+LG+ + EMA+G P
Sbjct: 218 KAVDWWALGVLIYEMAVGFPP 238
>AY101367-1|AAM34500.1| 1616|Homo sapiens myosin IIIA protein.
Length = 1616
Score = 114 bits (275), Expect = 5e-25
Identities = 95/308 (30%), Positives = 153/308 (49%), Gaps = 49/308 (15%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECN-FA 146
D +E +G+G G V KV +K G A K+ L+ I ++I E +L +
Sbjct: 19 DTWEITETIGKGTYGKVFKVLNKKNGQKAAVKI--LDPIHDIDEEIEAEYNILKALSDHP 76
Query: 147 HIVGFYGAFYSDGEIS-----ICMEYMDGGSL-DLI---LKKAGRIPESILGTITSAVLK 197
++V FYG ++ +++ + +E GGS+ DL+ LK+ R+ E ++ I L
Sbjct: 77 NVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALM 136
Query: 198 GLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDS--MANSFVGTRSYMSPE 255
GL +L + I HRDVK +NIL+ + G +K+ DFGVS QL + N+ VGT +M+PE
Sbjct: 137 GLQHLHNNKTI-HRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPE 195
Query: 256 RLQ-----GTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAP 310
+ T Y + D WSLG++ +E+ G P+ D + A+F
Sbjct: 196 VIACEQQLDTTYDARCDTWSLGITAIELGDGDPPL--ADLHPMRALF------------- 240
Query: 311 NSPRPMAIFELLDYIVNEPPPKL-PSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PR PPPKL ++S EF DF+ +CL K+ ++R + L+ H++I
Sbjct: 241 KIPR-------------NPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFI 287
Query: 370 RKAEAEKV 377
+ E + V
Sbjct: 288 TQIEGKDV 295
>AL391812-1|CAI17380.1| 1616|Homo sapiens myosin IIIA protein.
Length = 1616
Score = 114 bits (275), Expect = 5e-25
Identities = 95/308 (30%), Positives = 153/308 (49%), Gaps = 49/308 (15%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECN-FA 146
D +E +G+G G V KV +K G A K+ L+ I ++I E +L +
Sbjct: 19 DTWEITETIGKGTYGKVFKVLNKKNGQKAAVKI--LDPIHDIDEEIEAEYNILKALSDHP 76
Query: 147 HIVGFYGAFYSDGEIS-----ICMEYMDGGSL-DLI---LKKAGRIPESILGTITSAVLK 197
++V FYG ++ +++ + +E GGS+ DL+ LK+ R+ E ++ I L
Sbjct: 77 NVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALM 136
Query: 198 GLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDS--MANSFVGTRSYMSPE 255
GL +L + I HRDVK +NIL+ + G +K+ DFGVS QL + N+ VGT +M+PE
Sbjct: 137 GLQHLHNNKTI-HRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPE 195
Query: 256 RLQ-----GTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAP 310
+ T Y + D WSLG++ +E+ G P+ D + A+F
Sbjct: 196 VIACEQQLDTTYDARCDTWSLGITAIELGDGDPPL--ADLHPMRALF------------- 240
Query: 311 NSPRPMAIFELLDYIVNEPPPKL-PSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PR PPPKL ++S EF DF+ +CL K+ ++R + L+ H++I
Sbjct: 241 KIPR-------------NPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFI 287
Query: 370 RKAEAEKV 377
+ E + V
Sbjct: 288 TQIEGKDV 295
>AL360217-1|CAD13206.2| 1616|Homo sapiens myosin IIIA protein.
Length = 1616
Score = 114 bits (275), Expect = 5e-25
Identities = 95/308 (30%), Positives = 153/308 (49%), Gaps = 49/308 (15%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECN-FA 146
D +E +G+G G V KV +K G A K+ L+ I ++I E +L +
Sbjct: 19 DTWEITETIGKGTYGKVFKVLNKKNGQKAAVKI--LDPIHDIDEEIEAEYNILKALSDHP 76
Query: 147 HIVGFYGAFYSDGEIS-----ICMEYMDGGSL-DLI---LKKAGRIPESILGTITSAVLK 197
++V FYG ++ +++ + +E GGS+ DL+ LK+ R+ E ++ I L
Sbjct: 77 NVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALM 136
Query: 198 GLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDS--MANSFVGTRSYMSPE 255
GL +L + I HRDVK +NIL+ + G +K+ DFGVS QL + N+ VGT +M+PE
Sbjct: 137 GLQHLHNNKTI-HRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPE 195
Query: 256 RLQ-----GTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAP 310
+ T Y + D WSLG++ +E+ G P+ D + A+F
Sbjct: 196 VIACEQQLDTTYDARCDTWSLGITAIELGDGDPPL--ADLHPMRALF------------- 240
Query: 311 NSPRPMAIFELLDYIVNEPPPKL-PSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PR PPPKL ++S EF DF+ +CL K+ ++R + L+ H++I
Sbjct: 241 KIPR-------------NPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFI 287
Query: 370 RKAEAEKV 377
+ E + V
Sbjct: 288 TQIEGKDV 295
>AL358612-1|CAH73814.1| 1616|Homo sapiens myosin IIIA protein.
Length = 1616
Score = 114 bits (275), Expect = 5e-25
Identities = 95/308 (30%), Positives = 153/308 (49%), Gaps = 49/308 (15%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECN-FA 146
D +E +G+G G V KV +K G A K+ L+ I ++I E +L +
Sbjct: 19 DTWEITETIGKGTYGKVFKVLNKKNGQKAAVKI--LDPIHDIDEEIEAEYNILKALSDHP 76
Query: 147 HIVGFYGAFYSDGEIS-----ICMEYMDGGSL-DLI---LKKAGRIPESILGTITSAVLK 197
++V FYG ++ +++ + +E GGS+ DL+ LK+ R+ E ++ I L
Sbjct: 77 NVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALM 136
Query: 198 GLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDS--MANSFVGTRSYMSPE 255
GL +L + I HRDVK +NIL+ + G +K+ DFGVS QL + N+ VGT +M+PE
Sbjct: 137 GLQHLHNNKTI-HRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPE 195
Query: 256 RLQ-----GTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAP 310
+ T Y + D WSLG++ +E+ G P+ D + A+F
Sbjct: 196 VIACEQQLDTTYDARCDTWSLGITAIELGDGDPPL--ADLHPMRALF------------- 240
Query: 311 NSPRPMAIFELLDYIVNEPPPKL-PSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PR PPPKL ++S EF DF+ +CL K+ ++R + L+ H++I
Sbjct: 241 KIPR-------------NPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFI 287
Query: 370 RKAEAEKV 377
+ E + V
Sbjct: 288 TQIEGKDV 295
>AL162730-1|CAH71828.1| 351|Homo sapiens protein kinase,
cAMP-dependent, catalytic, gamma protein.
Length = 351
Score = 114 bits (275), Expect = 5e-25
Identities = 64/201 (31%), Positives = 109/201 (54%), Gaps = 4/201 (1%)
Query: 86 SDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLE--VKPAIKKQIIRELKVLHEC 143
S D FE+L LG G+ G VM VRH+ TG A K+++ + VK + I+ E ++L
Sbjct: 40 SSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAI 99
Query: 144 NFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLR 203
+F +V +F + + + MEY+ GG + L++ GR E + V+ + YL
Sbjct: 100 DFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLH 159
Query: 204 DKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYS 263
++HRD+KP N+L++ G +++ DFG + + + + GT Y++PE + Y+
Sbjct: 160 SLD-LIHRDLKPENLLIDQQGYLQVTDFGFA-KRVKGRTWTLCGTPEYLAPEIILSKGYN 217
Query: 264 VQSDIWSLGLSLVEMAIGMYP 284
D W+LG+ + EMA+G P
Sbjct: 218 KAVDWWALGVLIYEMAVGFPP 238
>AL162503-4|CAH73661.1| 1616|Homo sapiens myosin IIIA protein.
Length = 1616
Score = 114 bits (275), Expect = 5e-25
Identities = 95/308 (30%), Positives = 153/308 (49%), Gaps = 49/308 (15%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECN-FA 146
D +E +G+G G V KV +K G A K+ L+ I ++I E +L +
Sbjct: 19 DTWEITETIGKGTYGKVFKVLNKKNGQKAAVKI--LDPIHDIDEEIEAEYNILKALSDHP 76
Query: 147 HIVGFYGAFYSDGEIS-----ICMEYMDGGSL-DLI---LKKAGRIPESILGTITSAVLK 197
++V FYG ++ +++ + +E GGS+ DL+ LK+ R+ E ++ I L
Sbjct: 77 NVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALM 136
Query: 198 GLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDS--MANSFVGTRSYMSPE 255
GL +L + I HRDVK +NIL+ + G +K+ DFGVS QL + N+ VGT +M+PE
Sbjct: 137 GLQHLHNNKTI-HRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPE 195
Query: 256 RLQ-----GTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAP 310
+ T Y + D WSLG++ +E+ G P+ D + A+F
Sbjct: 196 VIACEQQLDTTYDARCDTWSLGITAIELGDGDPPL--ADLHPMRALF------------- 240
Query: 311 NSPRPMAIFELLDYIVNEPPPKL-PSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PR PPPKL ++S EF DF+ +CL K+ ++R + L+ H++I
Sbjct: 241 KIPR-------------NPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFI 287
Query: 370 RKAEAEKV 377
+ E + V
Sbjct: 288 TQIEGKDV 295
>AJ001597-1|CAA04863.1| 351|Homo sapiens cAMP-dependent protein
kinase gamma isoform protein.
Length = 351
Score = 114 bits (275), Expect = 5e-25
Identities = 64/201 (31%), Positives = 109/201 (54%), Gaps = 4/201 (1%)
Query: 86 SDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLE--VKPAIKKQIIRELKVLHEC 143
S D FE+L LG G+ G VM VRH+ TG A K+++ + VK + I+ E ++L
Sbjct: 40 SSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAI 99
Query: 144 NFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLR 203
+F +V +F + + + MEY+ GG + L++ GR E + V+ + YL
Sbjct: 100 DFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLH 159
Query: 204 DKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYS 263
++HRD+KP N+L++ G +++ DFG + + + + GT Y++PE + Y+
Sbjct: 160 SLD-LIHRDLKPENLLIDQQGYLQVTDFGFA-KRVKGRTWTLCGTPEYLAPEIILSKGYN 217
Query: 264 VQSDIWSLGLSLVEMAIGMYP 284
D W+LG+ + EMA+G P
Sbjct: 218 KAVDWWALGVLIYEMAVGFPP 238
>AF229172-1|AAF70861.1| 1615|Homo sapiens class III myosin protein.
Length = 1615
Score = 114 bits (275), Expect = 5e-25
Identities = 95/308 (30%), Positives = 153/308 (49%), Gaps = 49/308 (15%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECN-FA 146
D +E +G+G G V KV +K G A K+ L+ I ++I E +L +
Sbjct: 19 DTWEITETIGKGTYGKVFKVLNKKNGQKAAVKI--LDPIHDIDEEIEAEYNILKALSDHP 76
Query: 147 HIVGFYGAFYSDGEIS-----ICMEYMDGGSL-DLI---LKKAGRIPESILGTITSAVLK 197
++V FYG ++ +++ + +E GGS+ DL+ LK+ R+ E ++ I L
Sbjct: 77 NVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALM 136
Query: 198 GLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDS--MANSFVGTRSYMSPE 255
GL +L + I HRDVK +NIL+ + G +K+ DFGVS QL + N+ VGT +M+PE
Sbjct: 137 GLQHLHNNKTI-HRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPE 195
Query: 256 RLQ-----GTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAP 310
+ T Y + D WSLG++ +E+ G P+ D + A+F
Sbjct: 196 VIACEQQLDTTYDARCDTWSLGITAIELGDGDPPL--ADLHPMRALF------------- 240
Query: 311 NSPRPMAIFELLDYIVNEPPPKL-PSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
PR PPPKL ++S EF DF+ +CL K+ ++R + L+ H++I
Sbjct: 241 KIPR-------------NPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFI 287
Query: 370 RKAEAEKV 377
+ E + V
Sbjct: 288 TQIEGKDV 295
>AF200815-1|AAF97028.1| 1315|Homo sapiens FUSED serine/threonine
kinase protein.
Length = 1315
Score = 114 bits (274), Expect = 6e-25
Identities = 87/285 (30%), Positives = 142/285 (49%), Gaps = 35/285 (12%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLI-HLEVKPAIKKQIIRELKVLHECNFA 146
+ + L +G+G+ G V K R K + ++A K I L + + RE++++
Sbjct: 2 EKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHP 61
Query: 147 HIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKH 206
+IV +F +D E+ + +Y +G L IL+ G++PE + I + ++ L YL H
Sbjct: 62 NIVHMLDSFETDKEVVVVTDYAEG-ELFQILEDDGKLPEDQVQAIAAQLVSALYYLHS-H 119
Query: 207 AIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDS--MANSFVGTRSYMSPERLQGTHYSV 264
I+HRD+KP NIL+ G IK+CDFG + + + + S GT YMSPE ++ Y
Sbjct: 120 RILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDH 179
Query: 265 QSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDY 324
+D+WS+G L E+A+G PP T +IF+L+
Sbjct: 180 TADLWSVGCILYELAVGT----PPFYAT------------------------SIFQLVSL 211
Query: 325 IVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
I+ +P + PS I S FK+F+ L K+P +R L+ H +I
Sbjct: 212 ILKDPV-RWPSTI-SPCFKNFLQGLLTKDPRQRLSWPDLLYHPFI 254
>AB033104-1|BAA86592.1| 1311|Homo sapiens KIAA1278 protein protein.
Length = 1311
Score = 114 bits (274), Expect = 6e-25
Identities = 87/285 (30%), Positives = 142/285 (49%), Gaps = 35/285 (12%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLI-HLEVKPAIKKQIIRELKVLHECNFA 146
+ + L +G+G+ G V K R K + ++A K I L + + RE++++
Sbjct: 19 EKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHP 78
Query: 147 HIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKH 206
+IV +F +D E+ + +Y +G L IL+ G++PE + I + ++ L YL H
Sbjct: 79 NIVHMLDSFETDKEVVVVTDYAEG-ELFQILEDDGKLPEDQVQAIAAQLVSALYYLHS-H 136
Query: 207 AIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDS--MANSFVGTRSYMSPERLQGTHYSV 264
I+HRD+KP NIL+ G IK+CDFG + + + + S GT YMSPE ++ Y
Sbjct: 137 RILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDH 196
Query: 265 QSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDY 324
+D+WS+G L E+A+G PP T +IF+L+
Sbjct: 197 TADLWSVGCILYELAVGT----PPFYAT------------------------SIFQLVSL 228
Query: 325 IVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWI 369
I+ +P + PS I S FK+F+ L K+P +R L+ H +I
Sbjct: 229 ILKDPV-RWPSTI-SPCFKNFLQGLLTKDPRQRLSWPDLLYHPFI 271
>AB014587-1|BAA31662.1| 1175|Homo sapiens KIAA0687 protein protein.
Length = 1175
Score = 114 bits (274), Expect = 6e-25
Identities = 88/289 (30%), Positives = 145/289 (50%), Gaps = 47/289 (16%)
Query: 104 VMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHE-CNFAHIVGFYGAFYS----- 157
V K RH TG + A K+ ++V +++I E+ +L + + +I +YGAF
Sbjct: 2 VYKGRHVKTGQLAAIKV--MDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPG 59
Query: 158 -DGEISICMEYMDGGSLDLILK--KAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVK 214
D ++ + ME+ GS+ ++K K + E + I+ +L+GL++L H I HRD+K
Sbjct: 60 HDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVI-HRDIK 118
Query: 215 PSNILVNSNGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPERL-----QGTHYSVQSD 267
N+L+ N E+K+ DFGVS QL ++ N+F+GT +M+PE + Y +SD
Sbjct: 119 GQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSD 178
Query: 268 IWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIVN 327
+WS G++ +EMA G P+ D + A+F I
Sbjct: 179 LWSCGITAIEMAEGAPPL--CDMHPMRALF--------------------------LIPR 210
Query: 328 EPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEK 376
PPP+L S +S +F F++ CL KN +R + L+ H +IR E+
Sbjct: 211 NPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNER 259
>U35146-1|AAC50918.1| 493|Homo sapiens p56 KKIAMRE protein kinase
protein.
Length = 493
Score = 113 bits (273), Expect = 8e-25
Identities = 79/288 (27%), Positives = 135/288 (46%), Gaps = 6/288 (2%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMA-RKLIHLEVKPAIKKQIIRELKVLHECNFA 146
+ +E LG +G+G+ G+VMK R+K TG I+A +K + + +KK +RE+K+L +
Sbjct: 2 EKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHE 61
Query: 147 HIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKH 206
++V + E++D LD + + ++ ++ G+ + H
Sbjct: 62 NLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHS-H 120
Query: 207 AIMHRDVKPSNILVNSNGEIKICDFGVSGQLI--DSMANSFVGTRSYMSPERLQG-THYS 263
I+HRD+KP NILV+ +G +K+CDFG + L + +V TR Y +PE L G Y
Sbjct: 121 NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYG 180
Query: 264 VQSDIWSLGLSLVEMAIGMYPIP-PPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELL 322
D+W++G + EM +G P D L I Q + P+ L
Sbjct: 181 KAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRL 240
Query: 323 DYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIR 370
I P + S+ D +CL +PD+R L++H++ +
Sbjct: 241 PEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQ 288
>BC093981-1|AAH93981.1| 493|Homo sapiens cyclin-dependent
kinase-like 2 (CDC2-related kinase) protein.
Length = 493
Score = 113 bits (273), Expect = 8e-25
Identities = 79/288 (27%), Positives = 135/288 (46%), Gaps = 6/288 (2%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMA-RKLIHLEVKPAIKKQIIRELKVLHECNFA 146
+ +E LG +G+G+ G+VMK R+K TG I+A +K + + +KK +RE+K+L +
Sbjct: 2 EKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHE 61
Query: 147 HIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKH 206
++V + E++D LD + + ++ ++ G+ + H
Sbjct: 62 NLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHS-H 120
Query: 207 AIMHRDVKPSNILVNSNGEIKICDFGVSGQLI--DSMANSFVGTRSYMSPERLQG-THYS 263
I+HRD+KP NILV+ +G +K+CDFG + L + +V TR Y +PE L G Y
Sbjct: 121 NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYG 180
Query: 264 VQSDIWSLGLSLVEMAIGMYPIP-PPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELL 322
D+W++G + EM +G P D L I Q + P+ L
Sbjct: 181 KAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRL 240
Query: 323 DYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIR 370
I P + S+ D +CL +PD+R L++H++ +
Sbjct: 241 PEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQ 288
>BC093646-1|AAH93646.1| 493|Homo sapiens cyclin-dependent
kinase-like 2 (CDC2-related kinase) protein.
Length = 493
Score = 113 bits (273), Expect = 8e-25
Identities = 79/288 (27%), Positives = 135/288 (46%), Gaps = 6/288 (2%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMA-RKLIHLEVKPAIKKQIIRELKVLHECNFA 146
+ +E LG +G+G+ G+VMK R+K TG I+A +K + + +KK +RE+K+L +
Sbjct: 2 EKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHE 61
Query: 147 HIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKH 206
++V + E++D LD + + ++ ++ G+ + H
Sbjct: 62 NLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHS-H 120
Query: 207 AIMHRDVKPSNILVNSNGEIKICDFGVSGQLI--DSMANSFVGTRSYMSPERLQG-THYS 263
I+HRD+KP NILV+ +G +K+CDFG + L + +V TR Y +PE L G Y
Sbjct: 121 NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYG 180
Query: 264 VQSDIWSLGLSLVEMAIGMYPIP-PPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELL 322
D+W++G + EM +G P D L I Q + P+ L
Sbjct: 181 KAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRL 240
Query: 323 DYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIR 370
I P + S+ D +CL +PD+R L++H++ +
Sbjct: 241 PEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQ 288
>BC024179-1|AAH24179.1| 719|Homo sapiens p21(CDKN1A)-activated
kinase 7 protein.
Length = 719
Score = 113 bits (273), Expect = 8e-25
Identities = 62/192 (32%), Positives = 111/192 (57%), Gaps = 5/192 (2%)
Query: 95 ELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIVGFYGA 154
++G+G+ G+V K TG +A K + L K ++ + E+ ++ + + ++V Y +
Sbjct: 454 KIGEGSTGIVCIATEKHTGKQVAVKKMDLR-KQQRRELLFNEVVIMRDYHHDNVVDMYSS 512
Query: 155 FYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVK 214
+ E+ + ME+++GG+L I+ R+ E + T+ +VL+ LSYL ++ ++HRD+K
Sbjct: 513 YLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIATVCLSVLRALSYLHNQ-GVIHRDIK 570
Query: 215 PSNILVNSNGEIKICDFGVSGQLIDSMAN--SFVGTRSYMSPERLQGTHYSVQSDIWSLG 272
+IL+ S+G IK+ DFG Q+ + S VGT +M+PE + Y + DIWSLG
Sbjct: 571 SDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLG 630
Query: 273 LSLVEMAIGMYP 284
+ ++EM G P
Sbjct: 631 IMVIEMIDGEPP 642
>AL353612-1|CAI23529.1| 719|Homo sapiens p21(CDKN1A)-activated
kinase 7 protein.
Length = 719
Score = 113 bits (273), Expect = 8e-25
Identities = 62/192 (32%), Positives = 111/192 (57%), Gaps = 5/192 (2%)
Query: 95 ELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIVGFYGA 154
++G+G+ G+V K TG +A K + L K ++ + E+ ++ + + ++V Y +
Sbjct: 454 KIGEGSTGIVCIATEKHTGKQVAVKKMDLR-KQQRRELLFNEVVIMRDYHHDNVVDMYSS 512
Query: 155 FYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVK 214
+ E+ + ME+++GG+L I+ R+ E + T+ +VL+ LSYL ++ ++HRD+K
Sbjct: 513 YLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIATVCLSVLRALSYLHNQ-GVIHRDIK 570
Query: 215 PSNILVNSNGEIKICDFGVSGQLIDSMAN--SFVGTRSYMSPERLQGTHYSVQSDIWSLG 272
+IL+ S+G IK+ DFG Q+ + S VGT +M+PE + Y + DIWSLG
Sbjct: 571 SDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLG 630
Query: 273 LSLVEMAIGMYP 284
+ ++EM G P
Sbjct: 631 IMVIEMIDGEPP 642
>AL135935-1|CAH71126.1| 719|Homo sapiens p21(CDKN1A)-activated
kinase 7 protein.
Length = 719
Score = 113 bits (273), Expect = 8e-25
Identities = 62/192 (32%), Positives = 111/192 (57%), Gaps = 5/192 (2%)
Query: 95 ELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIVGFYGA 154
++G+G+ G+V K TG +A K + L K ++ + E+ ++ + + ++V Y +
Sbjct: 454 KIGEGSTGIVCIATEKHTGKQVAVKKMDLR-KQQRRELLFNEVVIMRDYHHDNVVDMYSS 512
Query: 155 FYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVK 214
+ E+ + ME+++GG+L I+ R+ E + T+ +VL+ LSYL ++ ++HRD+K
Sbjct: 513 YLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIATVCLSVLRALSYLHNQ-GVIHRDIK 570
Query: 215 PSNILVNSNGEIKICDFGVSGQLIDSMAN--SFVGTRSYMSPERLQGTHYSVQSDIWSLG 272
+IL+ S+G IK+ DFG Q+ + S VGT +M+PE + Y + DIWSLG
Sbjct: 571 SDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLG 630
Query: 273 LSLVEMAIGMYP 284
+ ++EM G P
Sbjct: 631 IMVIEMIDGEPP 642
>AL031652-1|CAI42211.1| 719|Homo sapiens p21(CDKN1A)-activated
kinase 7 protein.
Length = 719
Score = 113 bits (273), Expect = 8e-25
Identities = 62/192 (32%), Positives = 111/192 (57%), Gaps = 5/192 (2%)
Query: 95 ELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIVGFYGA 154
++G+G+ G+V K TG +A K + L K ++ + E+ ++ + + ++V Y +
Sbjct: 454 KIGEGSTGIVCIATEKHTGKQVAVKKMDLR-KQQRRELLFNEVVIMRDYHHDNVVDMYSS 512
Query: 155 FYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVK 214
+ E+ + ME+++GG+L I+ R+ E + T+ +VL+ LSYL ++ ++HRD+K
Sbjct: 513 YLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIATVCLSVLRALSYLHNQ-GVIHRDIK 570
Query: 215 PSNILVNSNGEIKICDFGVSGQLIDSMAN--SFVGTRSYMSPERLQGTHYSVQSDIWSLG 272
+IL+ S+G IK+ DFG Q+ + S VGT +M+PE + Y + DIWSLG
Sbjct: 571 SDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLG 630
Query: 273 LSLVEMAIGMYP 284
+ ++EM G P
Sbjct: 631 IMVIEMIDGEPP 642
>AB040812-1|BAA94194.1| 719|Homo sapiens protein kinase PAK5
protein.
Length = 719
Score = 113 bits (273), Expect = 8e-25
Identities = 62/192 (32%), Positives = 111/192 (57%), Gaps = 5/192 (2%)
Query: 95 ELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIVGFYGA 154
++G+G+ G+V K TG +A K + L K ++ + E+ ++ + + ++V Y +
Sbjct: 454 KIGEGSTGIVCIATEKHTGKQVAVKKMDLR-KQQRRELLFNEVVIMRDYHHDNVVDMYSS 512
Query: 155 FYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVK 214
+ E+ + ME+++GG+L I+ R+ E + T+ +VL+ LSYL ++ ++HRD+K
Sbjct: 513 YLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIATVCLSVLRALSYLHNQ-GVIHRDIK 570
Query: 215 PSNILVNSNGEIKICDFGVSGQLIDSMAN--SFVGTRSYMSPERLQGTHYSVQSDIWSLG 272
+IL+ S+G IK+ DFG Q+ + S VGT +M+PE + Y + DIWSLG
Sbjct: 571 SDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLG 630
Query: 273 LSLVEMAIGMYP 284
+ ++EM G P
Sbjct: 631 IMVIEMIDGEPP 642
>AB033090-1|BAA86578.1| 753|Homo sapiens KIAA1264 protein protein.
Length = 753
Score = 113 bits (273), Expect = 8e-25
Identities = 62/192 (32%), Positives = 111/192 (57%), Gaps = 5/192 (2%)
Query: 95 ELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIVGFYGA 154
++G+G+ G+V K TG +A K + L K ++ + E+ ++ + + ++V Y +
Sbjct: 488 KIGEGSTGIVCIATEKHTGKQVAVKKMDLR-KQQRRELLFNEVVIMRDYHHDNVVDMYSS 546
Query: 155 FYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVK 214
+ E+ + ME+++GG+L I+ R+ E + T+ +VL+ LSYL ++ ++HRD+K
Sbjct: 547 YLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIATVCLSVLRALSYLHNQ-GVIHRDIK 604
Query: 215 PSNILVNSNGEIKICDFGVSGQLIDSMAN--SFVGTRSYMSPERLQGTHYSVQSDIWSLG 272
+IL+ S+G IK+ DFG Q+ + S VGT +M+PE + Y + DIWSLG
Sbjct: 605 SDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLG 664
Query: 273 LSLVEMAIGMYP 284
+ ++EM G P
Sbjct: 665 IMVIEMIDGEPP 676
>AF263312-1|AAG38502.1| 1001|Homo sapiens STE20-like kinase protein.
Length = 1001
Score = 113 bits (272), Expect = 1e-24
Identities = 91/311 (29%), Positives = 147/311 (47%), Gaps = 37/311 (11%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKK--QIIRELKVLHECNFAH 147
F L E+G G+ G V R T ++A K + K + +K II+E+K L +
Sbjct: 28 FTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPN 87
Query: 148 IVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHA 207
+ + G + + + MEY G + DL+ + E + IT L+GL+YL H
Sbjct: 88 SIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHS-HT 146
Query: 208 IMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPE---RLQGTHYSV 264
++HRD+K NIL+ G++K+ DFG + + S ANSFVGT +M+PE + Y
Sbjct: 147 MIHRDIKAGNILLTEPGQVKLADFGSAS--MASPANSFVGTPYWMAPEVILAMDEGQYDG 204
Query: 265 QSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDY 324
+ D+WSLG++ +E+A P+ +A + A QNE SP N
Sbjct: 205 KVDVWSLGITCIELAERKPPLFNMNAMS-ALYHIAQNE--SPTLQSNE------------ 249
Query: 325 IVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVDIAGWVC 384
+SD F++ VD CL+K P +R + L+ H ++ + E V + +
Sbjct: 250 -------------WSDYFRNSVDSCLQKIPQDRPTSEELLKHIFVLRERPETV-LIDLIQ 295
Query: 385 KTMDLMPSTPN 395
+T D + N
Sbjct: 296 RTKDAVRELDN 306
>AF003199-1|AAB63374.1| 260|Homo sapiens MAP kinase kinase 7
protein.
Length = 260
Score = 113 bits (272), Expect = 1e-24
Identities = 59/145 (40%), Positives = 90/145 (62%), Gaps = 5/145 (3%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVL---HECN 144
+D E LGE+G G G V K+R + TG ++A K + K+I+ +L V+ H+C
Sbjct: 118 NDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCP 177
Query: 145 FAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRD 204
+ IV +G F ++ ++ I ME M + L + G IPE ILG +T A++K L YL++
Sbjct: 178 Y--IVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKE 235
Query: 205 KHAIMHRDVKPSNILVNSNGEIKIC 229
KH ++HRDVKPSNIL++ G+IK+C
Sbjct: 236 KHGVIHRDVKPSNILLDERGQIKLC 260
>U24153-1|AAA65442.1| 525|Homo sapiens p21-activated protein kinase
protein.
Length = 525
Score = 113 bits (271), Expect = 1e-24
Identities = 83/286 (29%), Positives = 142/286 (49%), Gaps = 31/286 (10%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
+ + ++GQG G V + G +A K I+L+ +P K+ II E+ V+ E +IV
Sbjct: 249 YTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPK-KELIINEILVMKELKNPNIV 307
Query: 150 GFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAIM 209
F ++ E+ + MEY+ GGSL ++ + + E+ + + L+ L +L + ++
Sbjct: 308 NFLDSYLVGDELFVVMEYLAGGSLTDVVTETACMDEAQIAAVCRECLQALEFLH-ANQVI 366
Query: 210 HRDVKPSNILVNSNGEIKICDFGVSGQLI--DSMANSFVGTRSYMSPERLQGTHYSVQSD 267
HRD+K N+L+ G +K+ DFG Q+ S ++ VGT +M+PE + Y + D
Sbjct: 367 HRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVD 426
Query: 268 IWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIVN 327
IWSLG+ +EM G PP NE N R + +
Sbjct: 427 IWSLGIMAIEMVEG----EPPYL----------NE--------NPLRALYLIATNGTPEL 464
Query: 328 EPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAE 373
+ P KL S IF +DF++RCL+ + ++R K L+ H +++ A+
Sbjct: 465 QNPEKL-SPIF----RDFLNRCLEMDVEKRGSAKELLQHPFLKLAK 505
>BC075064-1|AAH75064.2| 275|Homo sapiens AURKC protein protein.
Length = 275
Score = 113 bits (271), Expect = 1e-24
Identities = 65/202 (32%), Positives = 103/202 (50%), Gaps = 4/202 (1%)
Query: 85 LSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEV--KPAIKKQIIRELKVLHE 142
L+ DDFE LG+G G V R K + I+A K++ K ++ Q+ RE+++
Sbjct: 4 LTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAH 63
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYL 202
+I+ Y F+ + + +EY G L L+K+ ++ E TI + L+Y
Sbjct: 64 LQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYC 123
Query: 203 RDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY 262
DK I HRD+KP N+L+ GE+KI DFG S + GT Y+ PE ++G Y
Sbjct: 124 HDKKVI-HRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTY 182
Query: 263 SVQSDIWSLGLSLVEMAIGMYP 284
+ D+W +G+ E+ +G YP
Sbjct: 183 DEKVDLWCIGVLCYELLVG-YP 203
>AY714054-1|AAU04399.1| 306|Homo sapiens aurora-C protein.
Length = 306
Score = 113 bits (271), Expect = 1e-24
Identities = 65/202 (32%), Positives = 103/202 (50%), Gaps = 4/202 (1%)
Query: 85 LSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEV--KPAIKKQIIRELKVLHE 142
L+ DDFE LG+G G V R K + I+A K++ K ++ Q+ RE+++
Sbjct: 35 LTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAH 94
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYL 202
+I+ Y F+ + + +EY G L L+K+ ++ E TI + L+Y
Sbjct: 95 LQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYC 154
Query: 203 RDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY 262
DK I HRD+KP N+L+ GE+KI DFG S + GT Y+ PE ++G Y
Sbjct: 155 HDKKVI-HRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTY 213
Query: 263 SVQSDIWSLGLSLVEMAIGMYP 284
+ D+W +G+ E+ +G YP
Sbjct: 214 DEKVDLWCIGVLCYELLVG-YP 234
>AY661554-1|AAT64422.1| 290|Homo sapiens aurora/Ipl1-related kinase
3 transcript variant 1 protein.
Length = 290
Score = 113 bits (271), Expect = 1e-24
Identities = 65/202 (32%), Positives = 103/202 (50%), Gaps = 4/202 (1%)
Query: 85 LSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEV--KPAIKKQIIRELKVLHE 142
L+ DDFE LG+G G V R K + I+A K++ K ++ Q+ RE+++
Sbjct: 19 LTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAH 78
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYL 202
+I+ Y F+ + + +EY G L L+K+ ++ E TI + L+Y
Sbjct: 79 LQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYC 138
Query: 203 RDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY 262
DK I HRD+KP N+L+ GE+KI DFG S + GT Y+ PE ++G Y
Sbjct: 139 HDKKVI-HRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTY 197
Query: 263 SVQSDIWSLGLSLVEMAIGMYP 284
+ D+W +G+ E+ +G YP
Sbjct: 198 DEKVDLWCIGVLCYELLVG-YP 218
>AF054621-1|AAC25955.1| 309|Homo sapiens serine/threonine kinase
AIE2 protein.
Length = 309
Score = 113 bits (271), Expect = 1e-24
Identities = 65/202 (32%), Positives = 103/202 (50%), Gaps = 4/202 (1%)
Query: 85 LSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEV--KPAIKKQIIRELKVLHE 142
L+ DDFE LG+G G V R K + I+A K++ K ++ Q+ RE+++
Sbjct: 38 LTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAH 97
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYL 202
+I+ Y F+ + + +EY G L L+K+ ++ E TI + L+Y
Sbjct: 98 LQHPNILRLYNHFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYC 157
Query: 203 RDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY 262
DK I HRD+KP N+L+ GE+KI DFG S + GT Y+ PE ++G Y
Sbjct: 158 HDKKVI-HRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTY 216
Query: 263 SVQSDIWSLGLSLVEMAIGMYP 284
+ D+W +G+ E+ +G YP
Sbjct: 217 DEKVDLWCIGVLCYELLVG-YP 237
>AB017332-1|BAA76292.1| 309|Homo sapiens Aurora/Ipl1-related kinase
3 protein.
Length = 309
Score = 113 bits (271), Expect = 1e-24
Identities = 65/202 (32%), Positives = 103/202 (50%), Gaps = 4/202 (1%)
Query: 85 LSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEV--KPAIKKQIIRELKVLHE 142
L+ DDFE LG+G G V R K + I+A K++ K ++ Q+ RE+++
Sbjct: 38 LTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAH 97
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYL 202
+I+ Y F+ + + +EY G L L+K+ ++ E TI + L+Y
Sbjct: 98 LQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYC 157
Query: 203 RDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY 262
DK I HRD+KP N+L+ GE+KI DFG S + GT Y+ PE ++G Y
Sbjct: 158 HDKKVI-HRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTY 216
Query: 263 SVQSDIWSLGLSLVEMAIGMYP 284
+ D+W +G+ E+ +G YP
Sbjct: 217 DEKVDLWCIGVLCYELLVG-YP 237
>U67156-1|AAC50894.1| 1374|Homo sapiens mitogen-activated kinase
kinase kinase 5 protein.
Length = 1374
Score = 112 bits (270), Expect = 2e-24
Identities = 95/301 (31%), Positives = 158/301 (52%), Gaps = 40/301 (13%)
Query: 87 DDDFEKLGE---LGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHEC 143
D ++++ G+ LG+G G+V R S + +A K I E + + E+ +
Sbjct: 674 DYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIP-ERDSRYSQPLHEEIALHKHL 732
Query: 144 NFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILK-KAGRIP--ESILGTITSAVLKGLS 200
+IV + G+F +G I I ME + GGSL +L+ K G + E +G T +L+GL
Sbjct: 733 KHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLK 792
Query: 201 YLRDKHAIMHRDVKPSNILVNS-NGEIKICDFGVSGQL--IDSMANSFVGTRSYMSPERL 257
YL D I+HRD+K N+L+N+ +G +KI DFG S +L I+ +F GT YM+PE +
Sbjct: 793 YLHDNQ-IVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEII 851
Query: 258 -QGTH-YSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRP 315
+G Y +DIWSLG +++EMA G P + G+ P +
Sbjct: 852 DKGPRGYGKAADIWSLGCTIIEMATGKPPF------------------YELGE-PQA--- 889
Query: 316 MAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAE 375
A+F++ + V+ P++P + S E K F+ +C + +PD+RA L+ E+++ + +
Sbjct: 890 -AMFKVGMFKVH---PEIPESM-SAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKK 944
Query: 376 K 376
K
Sbjct: 945 K 945
>D84476-1|BAA12684.2| 1374|Homo sapiens apoptosis signal-regulating
kinase 1 protein.
Length = 1374
Score = 112 bits (270), Expect = 2e-24
Identities = 95/301 (31%), Positives = 158/301 (52%), Gaps = 40/301 (13%)
Query: 87 DDDFEKLGE---LGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHEC 143
D ++++ G+ LG+G G+V R S + +A K I E + + E+ +
Sbjct: 674 DYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIP-ERDSRYSQPLHEEIALHKHL 732
Query: 144 NFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILK-KAGRIP--ESILGTITSAVLKGLS 200
+IV + G+F +G I I ME + GGSL +L+ K G + E +G T +L+GL
Sbjct: 733 KHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLK 792
Query: 201 YLRDKHAIMHRDVKPSNILVNS-NGEIKICDFGVSGQL--IDSMANSFVGTRSYMSPERL 257
YL D I+HRD+K N+L+N+ +G +KI DFG S +L I+ +F GT YM+PE +
Sbjct: 793 YLHDNQ-IVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEII 851
Query: 258 -QGTH-YSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRP 315
+G Y +DIWSLG +++EMA G P + G+ P +
Sbjct: 852 DKGPRGYGKAADIWSLGCTIIEMATGKPPF------------------YELGE-PQA--- 889
Query: 316 MAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAE 375
A+F++ + V+ P++P + S E K F+ +C + +PD+RA L+ E+++ + +
Sbjct: 890 -AMFKVGMFKVH---PEIPESM-SAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKK 944
Query: 376 K 376
K
Sbjct: 945 K 945
>BC088829-1|AAH88829.1| 1374|Homo sapiens mitogen-activated protein
kinase kinase kinase 5 protein.
Length = 1374
Score = 112 bits (270), Expect = 2e-24
Identities = 95/301 (31%), Positives = 158/301 (52%), Gaps = 40/301 (13%)
Query: 87 DDDFEKLGE---LGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHEC 143
D ++++ G+ LG+G G+V R S + +A K I E + + E+ +
Sbjct: 674 DYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIP-ERDSRYSQPLHEEIALHKHL 732
Query: 144 NFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILK-KAGRIP--ESILGTITSAVLKGLS 200
+IV + G+F +G I I ME + GGSL +L+ K G + E +G T +L+GL
Sbjct: 733 KHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLK 792
Query: 201 YLRDKHAIMHRDVKPSNILVNS-NGEIKICDFGVSGQL--IDSMANSFVGTRSYMSPERL 257
YL D I+HRD+K N+L+N+ +G +KI DFG S +L I+ +F GT YM+PE +
Sbjct: 793 YLHDNQ-IVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEII 851
Query: 258 -QGTH-YSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRP 315
+G Y +DIWSLG +++EMA G P + G+ P +
Sbjct: 852 DKGPRGYGKAADIWSLGCTIIEMATGKPPF------------------YELGE-PQA--- 889
Query: 316 MAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAE 375
A+F++ + V+ P++P + S E K F+ +C + +PD+RA L+ E+++ + +
Sbjct: 890 -AMFKVGMFKVH---PEIPESM-SAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKK 944
Query: 376 K 376
K
Sbjct: 945 K 945
>BC054503-1|AAH54503.1| 1374|Homo sapiens mitogen-activated protein
kinase kinase kinase 5 protein.
Length = 1374
Score = 112 bits (270), Expect = 2e-24
Identities = 95/301 (31%), Positives = 158/301 (52%), Gaps = 40/301 (13%)
Query: 87 DDDFEKLGE---LGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHEC 143
D ++++ G+ LG+G G+V R S + +A K I E + + E+ +
Sbjct: 674 DYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIP-ERDSRYSQPLHEEIALHKHL 732
Query: 144 NFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILK-KAGRIP--ESILGTITSAVLKGLS 200
+IV + G+F +G I I ME + GGSL +L+ K G + E +G T +L+GL
Sbjct: 733 KHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLK 792
Query: 201 YLRDKHAIMHRDVKPSNILVNS-NGEIKICDFGVSGQL--IDSMANSFVGTRSYMSPERL 257
YL D I+HRD+K N+L+N+ +G +KI DFG S +L I+ +F GT YM+PE +
Sbjct: 793 YLHDNQ-IVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEII 851
Query: 258 -QGTH-YSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRP 315
+G Y +DIWSLG +++EMA G P + G+ P +
Sbjct: 852 DKGPRGYGKAADIWSLGCTIIEMATGKPPF------------------YELGE-PQA--- 889
Query: 316 MAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAE 375
A+F++ + V+ P++P + S E K F+ +C + +PD+RA L+ E+++ + +
Sbjct: 890 -AMFKVGMFKVH---PEIPESM-SAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKK 944
Query: 376 K 376
K
Sbjct: 945 K 945
>AL121933-1|CAI15470.1| 1374|Homo sapiens mitogen-activated protein
kinase kinase kinase 5 protein.
Length = 1374
Score = 112 bits (270), Expect = 2e-24
Identities = 95/301 (31%), Positives = 158/301 (52%), Gaps = 40/301 (13%)
Query: 87 DDDFEKLGE---LGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHEC 143
D ++++ G+ LG+G G+V R S + +A K I E + + E+ +
Sbjct: 674 DYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIP-ERDSRYSQPLHEEIALHKHL 732
Query: 144 NFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILK-KAGRIP--ESILGTITSAVLKGLS 200
+IV + G+F +G I I ME + GGSL +L+ K G + E +G T +L+GL
Sbjct: 733 KHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLK 792
Query: 201 YLRDKHAIMHRDVKPSNILVNS-NGEIKICDFGVSGQL--IDSMANSFVGTRSYMSPERL 257
YL D I+HRD+K N+L+N+ +G +KI DFG S +L I+ +F GT YM+PE +
Sbjct: 793 YLHDNQ-IVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEII 851
Query: 258 -QGTH-YSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRP 315
+G Y +DIWSLG +++EMA G P + G+ P +
Sbjct: 852 DKGPRGYGKAADIWSLGCTIIEMATGKPPF------------------YELGE-PQA--- 889
Query: 316 MAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAE 375
A+F++ + V+ P++P + S E K F+ +C + +PD+RA L+ E+++ + +
Sbjct: 890 -AMFKVGMFKVH---PEIPESM-SAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKK 944
Query: 376 K 376
K
Sbjct: 945 K 945
>AL024508-2|CAI20176.1| 1374|Homo sapiens mitogen-activated protein
kinase kinase kinase 5 protein.
Length = 1374
Score = 112 bits (270), Expect = 2e-24
Identities = 95/301 (31%), Positives = 158/301 (52%), Gaps = 40/301 (13%)
Query: 87 DDDFEKLGE---LGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHEC 143
D ++++ G+ LG+G G+V R S + +A K I E + + E+ +
Sbjct: 674 DYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIP-ERDSRYSQPLHEEIALHKHL 732
Query: 144 NFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILK-KAGRIP--ESILGTITSAVLKGLS 200
+IV + G+F +G I I ME + GGSL +L+ K G + E +G T +L+GL
Sbjct: 733 KHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLK 792
Query: 201 YLRDKHAIMHRDVKPSNILVNS-NGEIKICDFGVSGQL--IDSMANSFVGTRSYMSPERL 257
YL D I+HRD+K N+L+N+ +G +KI DFG S +L I+ +F GT YM+PE +
Sbjct: 793 YLHDNQ-IVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEII 851
Query: 258 -QGTH-YSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRP 315
+G Y +DIWSLG +++EMA G P + G+ P +
Sbjct: 852 DKGPRGYGKAADIWSLGCTIIEMATGKPPF------------------YELGE-PQA--- 889
Query: 316 MAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAE 375
A+F++ + V+ P++P + S E K F+ +C + +PD+RA L+ E+++ + +
Sbjct: 890 -AMFKVGMFKVH---PEIPESM-SAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKK 944
Query: 376 K 376
K
Sbjct: 945 K 945
>AK131359-1|BAD18511.1| 510|Homo sapiens protein ( Homo sapiens
cDNA FLJ16392 fis, clone TRACH2020048, moderately
similar to Mus musculus serine/threonine-protein kinase
NEK3 (Nek3) mRNA. ).
Length = 510
Score = 112 bits (270), Expect = 2e-24
Identities = 69/212 (32%), Positives = 117/212 (55%), Gaps = 5/212 (2%)
Query: 86 SDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNF 145
S DD+ L +G+G+ G + V+H+S+ + A K I L + + +E +L +
Sbjct: 21 SMDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKH 80
Query: 146 AHIVGFYGAFYSDGEISICMEYMDGGSL-DLILKKAGRI-PESILGTITSAVLKGLSYLR 203
+IV F +F ++G + I MEY DGG L I ++ G++ PE ++ + + G++++
Sbjct: 81 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 140
Query: 204 DKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTH 261
K ++HRD+K NI + NG++K+ DFG + L + M A ++VGT Y+ PE +
Sbjct: 141 KKR-VLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLP 199
Query: 262 YSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTL 293
Y+ +SDIWSLG L E+ +P K L
Sbjct: 200 YNNKSDIWSLGCILYELCTLKHPFQANSWKNL 231
>AF059681-1|AAC77369.1| 275|Homo sapiens serine/threonine kinase 13
protein.
Length = 275
Score = 112 bits (270), Expect = 2e-24
Identities = 66/202 (32%), Positives = 103/202 (50%), Gaps = 4/202 (1%)
Query: 85 LSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEV--KPAIKKQIIRELKVLHE 142
L+ DDFE LG+G G V R K + I+A K++ K ++ Q+ RE+++
Sbjct: 4 LTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAH 63
Query: 143 CNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYL 202
+I+ Y F+ + + +EY G L L+K+ ++ E TI V L+Y
Sbjct: 64 LQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEEVADALTYC 123
Query: 203 RDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY 262
DK I HRD+KP N+L+ GE+KI DFG S + GT Y+ PE ++G Y
Sbjct: 124 HDKKVI-HRDIKPENLLLGFRGEVKIADFGWSVHTPLPERKTMCGTLDYLPPEMIEGRTY 182
Query: 263 SVQSDIWSLGLSLVEMAIGMYP 284
+ D+W +G+ E+ +G YP
Sbjct: 183 DEKVDLWCIGVLCYELLVG-YP 203
>AB209093-1|BAD92330.1| 1455|Homo sapiens mitogen-activated protein
kinase kinase kinase 5 variant protein.
Length = 1455
Score = 112 bits (270), Expect = 2e-24
Identities = 95/301 (31%), Positives = 158/301 (52%), Gaps = 40/301 (13%)
Query: 87 DDDFEKLGE---LGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHEC 143
D ++++ G+ LG+G G+V R S + +A K I E + + E+ +
Sbjct: 754 DYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIP-ERDSRYSQPLHEEIALHKHL 812
Query: 144 NFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILK-KAGRIP--ESILGTITSAVLKGLS 200
+IV + G+F +G I I ME + GGSL +L+ K G + E +G T +L+GL
Sbjct: 813 KHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLK 872
Query: 201 YLRDKHAIMHRDVKPSNILVNS-NGEIKICDFGVSGQL--IDSMANSFVGTRSYMSPERL 257
YL D I+HRD+K N+L+N+ +G +KI DFG S +L I+ +F GT YM+PE +
Sbjct: 873 YLHDNQ-IVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEII 931
Query: 258 -QGTH-YSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRP 315
+G Y +DIWSLG +++EMA G P + G+ P +
Sbjct: 932 DKGPRGYGKAADIWSLGCTIIEMATGKPPF------------------YELGE-PQA--- 969
Query: 316 MAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAE 375
A+F++ + V+ P++P + S E K F+ +C + +PD+RA L+ E+++ + +
Sbjct: 970 -AMFKVGMFKVH---PEIPESM-SAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKK 1024
Query: 376 K 376
K
Sbjct: 1025 K 1025
>BC019916-1|AAH19916.2| 506|Homo sapiens NIMA (never in mitosis
gene a)-related kinase 3 protein.
Length = 506
Score = 112 bits (269), Expect = 2e-24
Identities = 68/210 (32%), Positives = 116/210 (55%), Gaps = 5/210 (2%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAH 147
DD+ L +G+G+ G + V+H+S+ + A K I L + + +E +L + +
Sbjct: 2 DDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPN 61
Query: 148 IVGFYGAFYSDGEISICMEYMDGGSL-DLILKKAGRI-PESILGTITSAVLKGLSYLRDK 205
IV F +F ++G + I MEY DGG L I ++ G++ PE ++ + + G++++ K
Sbjct: 62 IVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKK 121
Query: 206 HAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYS 263
++HRD+K NI + NG++K+ DFG + L + M A ++VGT Y+ PE + Y+
Sbjct: 122 R-VLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN 180
Query: 264 VQSDIWSLGLSLVEMAIGMYPIPPPDAKTL 293
+SDIWSLG L E+ +P K L
Sbjct: 181 NKSDIWSLGCILYELCTLKHPFQANSWKNL 210
>BC005298-1|AAH05298.1| 346|Homo sapiens cyclin-dependent kinase 7
(MO15 homolog, Xenopus laevis, cdk-activating kinase)
protein.
Length = 346
Score = 112 bits (269), Expect = 2e-24
Identities = 74/210 (35%), Positives = 117/210 (55%), Gaps = 13/210 (6%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHL----EVKPAIKKQIIRELKVLHECNF 145
+EKL LG+G V K R K+T I+A K I L E K I + +RE+K+L E +
Sbjct: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71
Query: 146 AHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRI-PESILGTITSAVLKGLSYLRD 204
+I+G AF IS+ ++M+ L++I+K + S + L+GL YL
Sbjct: 72 PNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH- 129
Query: 205 KHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSF---VGTRSYMSPERLQGTH 261
+H I+HRD+KP+N+L++ NG +K+ DFG++ + S ++ V TR Y +PE L G
Sbjct: 130 RHWILHRDLKPNNLLLDENGVLKLADFGLA-KSFGSPNRAYTHQVVTRWYRAPELLFGAR 188
Query: 262 -YSVQSDIWSLGLSLVEMAIGMYPIPPPDA 290
Y V D+W++G L E+ + + P P D+
Sbjct: 189 MYGVGVDMWAVGCILAELLLRV-PFLPGDS 217
>AL139082-7|CAI12895.1| 507|Homo sapiens NIMA (never in mitosis
gene a)-related kinase 3 protein.
Length = 507
Score = 112 bits (269), Expect = 2e-24
Identities = 68/210 (32%), Positives = 116/210 (55%), Gaps = 5/210 (2%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAH 147
DD+ L +G+G+ G + V+H+S+ + A K I L + + +E +L + +
Sbjct: 2 DDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPN 61
Query: 148 IVGFYGAFYSDGEISICMEYMDGGSL-DLILKKAGRI-PESILGTITSAVLKGLSYLRDK 205
IV F +F ++G + I MEY DGG L I ++ G++ PE ++ + + G++++ K
Sbjct: 62 IVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKK 121
Query: 206 HAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYS 263
++HRD+K NI + NG++K+ DFG + L + M A ++VGT Y+ PE + Y+
Sbjct: 122 R-VLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN 180
Query: 264 VQSDIWSLGLSLVEMAIGMYPIPPPDAKTL 293
+SDIWSLG L E+ +P K L
Sbjct: 181 NKSDIWSLGCILYELCTLKHPFQANSWKNL 210
>Y13120-1|CAA73587.1| 346|Homo sapiens serine/threonine protein
kinase protein.
Length = 346
Score = 111 bits (268), Expect = 3e-24
Identities = 74/210 (35%), Positives = 117/210 (55%), Gaps = 13/210 (6%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHL----EVKPAIKKQIIRELKVLHECNF 145
+EKL LG+G V K R K+T I+A K I L E K I + +RE+K+L E +
Sbjct: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71
Query: 146 AHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRI-PESILGTITSAVLKGLSYLRD 204
+I+G AF IS+ ++M+ L++I+K + S + L+GL YL
Sbjct: 72 PNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH- 129
Query: 205 KHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSF---VGTRSYMSPERLQGTH 261
+H I+HRD+KP+N+L++ NG +K+ DFG++ + S ++ V TR Y +PE L G
Sbjct: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLA-KSFGSPNRAYTHQVVTRWYRAPELLFGAR 188
Query: 262 -YSVQSDIWSLGLSLVEMAIGMYPIPPPDA 290
Y V D+W++G L E+ + + P P D+
Sbjct: 189 MYGVGVDMWAVGCILAELLLRV-PFLPGDS 217
>X79193-1|CAA55785.1| 346|Homo sapiens MO15/CDK-activating kinase
(CAK) protein.
Length = 346
Score = 111 bits (268), Expect = 3e-24
Identities = 74/210 (35%), Positives = 117/210 (55%), Gaps = 13/210 (6%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHL----EVKPAIKKQIIRELKVLHECNF 145
+EKL LG+G V K R K+T I+A K I L E K I + +RE+K+L E +
Sbjct: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71
Query: 146 AHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRI-PESILGTITSAVLKGLSYLRD 204
+I+G AF IS+ ++M+ L++I+K + S + L+GL YL
Sbjct: 72 PNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH- 129
Query: 205 KHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSF---VGTRSYMSPERLQGTH 261
+H I+HRD+KP+N+L++ NG +K+ DFG++ + S ++ V TR Y +PE L G
Sbjct: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLA-KSFGSPNRAYTHQVVTRWYRAPELLFGAR 188
Query: 262 -YSVQSDIWSLGLSLVEMAIGMYPIPPPDA 290
Y V D+W++G L E+ + + P P D+
Sbjct: 189 MYGVGVDMWAVGCILAELLLRV-PFLPGDS 217
>X77743-1|CAA54793.1| 346|Homo sapiens CDK activating kinase
protein.
Length = 346
Score = 111 bits (268), Expect = 3e-24
Identities = 74/210 (35%), Positives = 117/210 (55%), Gaps = 13/210 (6%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHL----EVKPAIKKQIIRELKVLHECNF 145
+EKL LG+G V K R K+T I+A K I L E K I + +RE+K+L E +
Sbjct: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71
Query: 146 AHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRI-PESILGTITSAVLKGLSYLRD 204
+I+G AF IS+ ++M+ L++I+K + S + L+GL YL
Sbjct: 72 PNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH- 129
Query: 205 KHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSF---VGTRSYMSPERLQGTH 261
+H I+HRD+KP+N+L++ NG +K+ DFG++ + S ++ V TR Y +PE L G
Sbjct: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLA-KSFGSPNRAYTHQVVTRWYRAPELLFGAR 188
Query: 262 -YSVQSDIWSLGLSLVEMAIGMYPIPPPDA 290
Y V D+W++G L E+ + + P P D+
Sbjct: 189 MYGVGVDMWAVGCILAELLLRV-PFLPGDS 217
>X77303-1|CAA54508.1| 346|Homo sapiens Cdk-activating kinase
protein.
Length = 346
Score = 111 bits (268), Expect = 3e-24
Identities = 74/210 (35%), Positives = 117/210 (55%), Gaps = 13/210 (6%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHL----EVKPAIKKQIIRELKVLHECNF 145
+EKL LG+G V K R K+T I+A K I L E K I + +RE+K+L E +
Sbjct: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71
Query: 146 AHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRI-PESILGTITSAVLKGLSYLRD 204
+I+G AF IS+ ++M+ L++I+K + S + L+GL YL
Sbjct: 72 PNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH- 129
Query: 205 KHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSF---VGTRSYMSPERLQGTH 261
+H I+HRD+KP+N+L++ NG +K+ DFG++ + S ++ V TR Y +PE L G
Sbjct: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLA-KSFGSPNRAYTHQVVTRWYRAPELLFGAR 188
Query: 262 -YSVQSDIWSLGLSLVEMAIGMYPIPPPDA 290
Y V D+W++G L E+ + + P P D+
Sbjct: 189 MYGVGVDMWAVGCILAELLLRV-PFLPGDS 217
>L20320-1|AAA36657.1| 346|Homo sapiens protein serine/threonine
kinase protein.
Length = 346
Score = 111 bits (268), Expect = 3e-24
Identities = 74/210 (35%), Positives = 117/210 (55%), Gaps = 13/210 (6%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHL----EVKPAIKKQIIRELKVLHECNF 145
+EKL LG+G V K R K+T I+A K I L E K I + +RE+K+L E +
Sbjct: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71
Query: 146 AHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRI-PESILGTITSAVLKGLSYLRD 204
+I+G AF IS+ ++M+ L++I+K + S + L+GL YL
Sbjct: 72 PNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH- 129
Query: 205 KHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSF---VGTRSYMSPERLQGTH 261
+H I+HRD+KP+N+L++ NG +K+ DFG++ + S ++ V TR Y +PE L G
Sbjct: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLA-KSFGSPNRAYTHQVVTRWYRAPELLFGAR 188
Query: 262 -YSVQSDIWSLGLSLVEMAIGMYPIPPPDA 290
Y V D+W++G L E+ + + P P D+
Sbjct: 189 MYGVGVDMWAVGCILAELLLRV-PFLPGDS 217
>BC000834-1|AAH00834.1| 346|Homo sapiens cyclin-dependent kinase 7
(MO15 homolog, Xenopus laevis, cdk-activating kinase)
protein.
Length = 346
Score = 111 bits (268), Expect = 3e-24
Identities = 74/210 (35%), Positives = 117/210 (55%), Gaps = 13/210 (6%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHL----EVKPAIKKQIIRELKVLHECNF 145
+EKL LG+G V K R K+T I+A K I L E K I + +RE+K+L E +
Sbjct: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71
Query: 146 AHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRI-PESILGTITSAVLKGLSYLRD 204
+I+G AF IS+ ++M+ L++I+K + S + L+GL YL
Sbjct: 72 PNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH- 129
Query: 205 KHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSF---VGTRSYMSPERLQGTH 261
+H I+HRD+KP+N+L++ NG +K+ DFG++ + S ++ V TR Y +PE L G
Sbjct: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLA-KSFGSPNRAYTHQVVTRWYRAPELLFGAR 188
Query: 262 -YSVQSDIWSLGLSLVEMAIGMYPIPPPDA 290
Y V D+W++G L E+ + + P P D+
Sbjct: 189 MYGVGVDMWAVGCILAELLLRV-PFLPGDS 217
>AY130859-1|AAM77799.1| 346|Homo sapiens cyclin-dependent kinase 7
protein.
Length = 346
Score = 111 bits (268), Expect = 3e-24
Identities = 74/210 (35%), Positives = 117/210 (55%), Gaps = 13/210 (6%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHL----EVKPAIKKQIIRELKVLHECNF 145
+EKL LG+G V K R K+T I+A K I L E K I + +RE+K+L E +
Sbjct: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71
Query: 146 AHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRI-PESILGTITSAVLKGLSYLRD 204
+I+G AF IS+ ++M+ L++I+K + S + L+GL YL
Sbjct: 72 PNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH- 129
Query: 205 KHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSF---VGTRSYMSPERLQGTH 261
+H I+HRD+KP+N+L++ NG +K+ DFG++ + S ++ V TR Y +PE L G
Sbjct: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLA-KSFGSPNRAYTHQVVTRWYRAPELLFGAR 188
Query: 262 -YSVQSDIWSLGLSLVEMAIGMYPIPPPDA 290
Y V D+W++G L E+ + + P P D+
Sbjct: 189 MYGVGVDMWAVGCILAELLLRV-PFLPGDS 217
>Z98049-1|CAI20579.1| 733|Homo sapiens ribosomal protein S6 kinase,
90kDa, polypeptide 2 protein.
Length = 733
Score = 111 bits (267), Expect = 4e-24
Identities = 74/235 (31%), Positives = 121/235 (51%), Gaps = 11/235 (4%)
Query: 70 RRIEVFLCQKEKIGELSDDDFEKLGELGQGNGG---VVMKVRHKSTGLIMARKLIH---L 123
+ I++ KE + FE L LGQG+ G +V KV+ G + A K++ L
Sbjct: 39 KEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATL 98
Query: 124 EVKPAIKKQIIRELKVLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRI 183
+V+ ++ ++ R+ +L E N IV + AF ++G++ + ++++ GG L L K
Sbjct: 99 KVRDRVRSKMERD--ILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMF 156
Query: 184 PESILGTITSAVLKGLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLI--DSM 241
E + + + L +L I++RD+KP NIL++ G IKI DFG+S + I D
Sbjct: 157 TEEDVKFYLAELALALDHLHSL-GIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKR 215
Query: 242 ANSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAI 296
A SF GT YM+PE + ++ +D WS G+ + EM G P D K A+
Sbjct: 216 AYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMAL 270
Score = 77.0 bits (181), Expect = 1e-13
Identities = 61/205 (29%), Positives = 97/205 (47%), Gaps = 15/205 (7%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAH 147
D +E ++G G+ V + HK+T A K+I K+ E+++L
Sbjct: 413 DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKS-----KRDPSEEIEILLRYGQHP 467
Query: 148 IVGFYGAFYSDGE-ISICMEYMDGGSL-DLILKKAGRIPESILGTITSAVLKGLSYLRDK 205
+ Y DG+ + + ME M GG L D IL++ E + + K + YL +
Sbjct: 468 NIITLKDVYDDGKFVYLVMELMRGGELLDRILRQR-YFSEREASDVLCTITKTMDYLHSQ 526
Query: 206 HAIMHRDVKPSNILVNSNG----EIKICDFGVSGQLI--DSMANSFVGTRSYMSPERLQG 259
++HRD+KPSNIL I++CDFG + QL + + + T ++++PE L+
Sbjct: 527 -GVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKR 585
Query: 260 THYSVQSDIWSLGLSLVEMAIGMYP 284
Y DIWSLG+ L M G P
Sbjct: 586 QGYDAACDIWSLGILLYTMLAGFTP 610
>X85106-1|CAA59427.1| 733|Homo sapiens ribosomal S6 kinase protein.
Length = 733
Score = 111 bits (267), Expect = 4e-24
Identities = 74/235 (31%), Positives = 121/235 (51%), Gaps = 11/235 (4%)
Query: 70 RRIEVFLCQKEKIGELSDDDFEKLGELGQGNGG---VVMKVRHKSTGLIMARKLIH---L 123
+ I++ KE + FE L LGQG+ G +V KV+ G + A K++ L
Sbjct: 39 KEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATL 98
Query: 124 EVKPAIKKQIIRELKVLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRI 183
+V+ ++ ++ R+ +L E N IV + AF ++G++ + ++++ GG L L K
Sbjct: 99 KVRDRVRSKMERD--ILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMF 156
Query: 184 PESILGTITSAVLKGLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLI--DSM 241
E + + + L +L I++RD+KP NIL++ G IKI DFG+S + I D
Sbjct: 157 TEEDVKFYLAELALALDHLHSL-GIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKR 215
Query: 242 ANSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAI 296
A SF GT YM+PE + ++ +D WS G+ + EM G P D K A+
Sbjct: 216 AYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMAL 270
Score = 77.0 bits (181), Expect = 1e-13
Identities = 61/205 (29%), Positives = 97/205 (47%), Gaps = 15/205 (7%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAH 147
D +E ++G G+ V + HK+T A K+I K+ E+++L
Sbjct: 413 DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKS-----KRDPSEEIEILLRYGQHP 467
Query: 148 IVGFYGAFYSDGE-ISICMEYMDGGSL-DLILKKAGRIPESILGTITSAVLKGLSYLRDK 205
+ Y DG+ + + ME M GG L D IL++ E + + K + YL +
Sbjct: 468 NIITLKDVYDDGKFVYLVMELMRGGELLDRILRQR-YFSEREASDVLCTITKTMDYLHSQ 526
Query: 206 HAIMHRDVKPSNILVNSNG----EIKICDFGVSGQLI--DSMANSFVGTRSYMSPERLQG 259
++HRD+KPSNIL I++CDFG + QL + + + T ++++PE L+
Sbjct: 527 -GVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKR 585
Query: 260 THYSVQSDIWSLGLSLVEMAIGMYP 284
Y DIWSLG+ L M G P
Sbjct: 586 QGYDAACDIWSLGILLYTMLAGFTP 610
>BC002363-1|AAH02363.1| 733|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 2 protein.
Length = 733
Score = 111 bits (267), Expect = 4e-24
Identities = 74/235 (31%), Positives = 121/235 (51%), Gaps = 11/235 (4%)
Query: 70 RRIEVFLCQKEKIGELSDDDFEKLGELGQGNGG---VVMKVRHKSTGLIMARKLIH---L 123
+ I++ KE + FE L LGQG+ G +V KV+ G + A K++ L
Sbjct: 39 KEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATL 98
Query: 124 EVKPAIKKQIIRELKVLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRI 183
+V+ ++ ++ R+ +L E N IV + AF ++G++ + ++++ GG L L K
Sbjct: 99 KVRDRVRSKMERD--ILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMF 156
Query: 184 PESILGTITSAVLKGLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLI--DSM 241
E + + + L +L I++RD+KP NIL++ G IKI DFG+S + I D
Sbjct: 157 TEEDVKFYLAELALALDHLHSL-GIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKR 215
Query: 242 ANSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAI 296
A SF GT YM+PE + ++ +D WS G+ + EM G P D K A+
Sbjct: 216 AYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMAL 270
Score = 77.0 bits (181), Expect = 1e-13
Identities = 61/205 (29%), Positives = 97/205 (47%), Gaps = 15/205 (7%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAH 147
D +E ++G G+ V + HK+T A K+I K+ E+++L
Sbjct: 413 DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKS-----KRDPSEEIEILLRYGQHP 467
Query: 148 IVGFYGAFYSDGE-ISICMEYMDGGSL-DLILKKAGRIPESILGTITSAVLKGLSYLRDK 205
+ Y DG+ + + ME M GG L D IL++ E + + K + YL +
Sbjct: 468 NIITLKDVYDDGKFVYLVMELMRGGELLDRILRQR-YFSEREASDVLCTITKTMDYLHSQ 526
Query: 206 HAIMHRDVKPSNILVNSNG----EIKICDFGVSGQLI--DSMANSFVGTRSYMSPERLQG 259
++HRD+KPSNIL I++CDFG + QL + + + T ++++PE L+
Sbjct: 527 -GVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKR 585
Query: 260 THYSVQSDIWSLGLSLVEMAIGMYP 284
Y DIWSLG+ L M G P
Sbjct: 586 QGYDAACDIWSLGILLYTMLAGFTP 610
>AL022069-2|CAI19651.1| 733|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 2 protein.
Length = 733
Score = 111 bits (267), Expect = 4e-24
Identities = 74/235 (31%), Positives = 121/235 (51%), Gaps = 11/235 (4%)
Query: 70 RRIEVFLCQKEKIGELSDDDFEKLGELGQGNGG---VVMKVRHKSTGLIMARKLIH---L 123
+ I++ KE + FE L LGQG+ G +V KV+ G + A K++ L
Sbjct: 39 KEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATL 98
Query: 124 EVKPAIKKQIIRELKVLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRI 183
+V+ ++ ++ R+ +L E N IV + AF ++G++ + ++++ GG L L K
Sbjct: 99 KVRDRVRSKMERD--ILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMF 156
Query: 184 PESILGTITSAVLKGLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLI--DSM 241
E + + + L +L I++RD+KP NIL++ G IKI DFG+S + I D
Sbjct: 157 TEEDVKFYLAELALALDHLHSL-GIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKR 215
Query: 242 ANSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAI 296
A SF GT YM+PE + ++ +D WS G+ + EM G P D K A+
Sbjct: 216 AYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMAL 270
Score = 77.0 bits (181), Expect = 1e-13
Identities = 61/205 (29%), Positives = 97/205 (47%), Gaps = 15/205 (7%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAH 147
D +E ++G G+ V + HK+T A K+I K+ E+++L
Sbjct: 413 DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKS-----KRDPSEEIEILLRYGQHP 467
Query: 148 IVGFYGAFYSDGE-ISICMEYMDGGSL-DLILKKAGRIPESILGTITSAVLKGLSYLRDK 205
+ Y DG+ + + ME M GG L D IL++ E + + K + YL +
Sbjct: 468 NIITLKDVYDDGKFVYLVMELMRGGELLDRILRQR-YFSEREASDVLCTITKTMDYLHSQ 526
Query: 206 HAIMHRDVKPSNILVNSNG----EIKICDFGVSGQLI--DSMANSFVGTRSYMSPERLQG 259
++HRD+KPSNIL I++CDFG + QL + + + T ++++PE L+
Sbjct: 527 -GVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKR 585
Query: 260 THYSVQSDIWSLGLSLVEMAIGMYP 284
Y DIWSLG+ L M G P
Sbjct: 586 QGYDAACDIWSLGILLYTMLAGFTP 610
>AB209116-1|BAD92353.1| 806|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 2 isoform b variant protein.
Length = 806
Score = 111 bits (267), Expect = 4e-24
Identities = 74/235 (31%), Positives = 121/235 (51%), Gaps = 11/235 (4%)
Query: 70 RRIEVFLCQKEKIGELSDDDFEKLGELGQGNGG---VVMKVRHKSTGLIMARKLIH---L 123
+ I++ KE + FE L LGQG+ G +V KV+ G + A K++ L
Sbjct: 112 KEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATL 171
Query: 124 EVKPAIKKQIIRELKVLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRI 183
+V+ ++ ++ R+ +L E N IV + AF ++G++ + ++++ GG L L K
Sbjct: 172 KVRDRVRSKMERD--ILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMF 229
Query: 184 PESILGTITSAVLKGLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLI--DSM 241
E + + + L +L I++RD+KP NIL++ G IKI DFG+S + I D
Sbjct: 230 TEEDVKFYLAELALALDHLHSL-GIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKR 288
Query: 242 ANSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAI 296
A SF GT YM+PE + ++ +D WS G+ + EM G P D K A+
Sbjct: 289 AYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMAL 343
Score = 77.0 bits (181), Expect = 1e-13
Identities = 61/205 (29%), Positives = 97/205 (47%), Gaps = 15/205 (7%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAH 147
D +E ++G G+ V + HK+T A K+I K+ E+++L
Sbjct: 486 DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKS-----KRDPSEEIEILLRYGQHP 540
Query: 148 IVGFYGAFYSDGE-ISICMEYMDGGSL-DLILKKAGRIPESILGTITSAVLKGLSYLRDK 205
+ Y DG+ + + ME M GG L D IL++ E + + K + YL +
Sbjct: 541 NIITLKDVYDDGKFVYLVMELMRGGELLDRILRQR-YFSEREASDVLCTITKTMDYLHSQ 599
Query: 206 HAIMHRDVKPSNILVNSNG----EIKICDFGVSGQLI--DSMANSFVGTRSYMSPERLQG 259
++HRD+KPSNIL I++CDFG + QL + + + T ++++PE L+
Sbjct: 600 -GVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKR 658
Query: 260 THYSVQSDIWSLGLSLVEMAIGMYP 284
Y DIWSLG+ L M G P
Sbjct: 659 QGYDAACDIWSLGILLYTMLAGFTP 683
>U78876-1|AAB41729.1| 626|Homo sapiens MEK kinase 3 protein.
Length = 626
Score = 111 bits (266), Expect = 6e-24
Identities = 80/227 (35%), Positives = 120/227 (52%), Gaps = 15/227 (6%)
Query: 96 LGQGNGGVVMKVRHKSTGLIMARKLIHLEV-KPAIKKQIIR---ELKVLHECNFAHIVGF 151
LGQG G V TG +A K + + P K++ E+++L IV +
Sbjct: 368 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQY 427
Query: 152 YGAFYSDGE--ISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAIM 209
YG E ++I MEYM GGS+ LK G + ES+ T +L+G+SYL + I+
Sbjct: 428 YGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHS-NMIV 486
Query: 210 HRDVKPSNILVNSNGEIKICDFGVSGQL-----IDSMANSFVGTRSYMSPERLQGTHYSV 264
HRD+K +NIL +S G +K+ DFG S +L + S GT +MSPE + G Y
Sbjct: 487 HRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGR 546
Query: 265 QSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPN 311
++D+WSLG ++VEM + P P + + +AAIF + +P Q P+
Sbjct: 547 KADVWSLGCTVVEM-LTEKP-PWAEYEAMAAIFKIATQPTNP-QLPS 590
>DQ454151-1|ABE11554.1| 622|Homo sapiens mitogen-activated protein
kinase kinase kinase 3 variant 2 protein.
Length = 622
Score = 111 bits (266), Expect = 6e-24
Identities = 80/227 (35%), Positives = 120/227 (52%), Gaps = 15/227 (6%)
Query: 96 LGQGNGGVVMKVRHKSTGLIMARKLIHLEV-KPAIKKQIIR---ELKVLHECNFAHIVGF 151
LGQG G V TG +A K + + P K++ E+++L IV +
Sbjct: 364 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQY 423
Query: 152 YGAFYSDGE--ISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAIM 209
YG E ++I MEYM GGS+ LK G + ES+ T +L+G+SYL + I+
Sbjct: 424 YGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHS-NMIV 482
Query: 210 HRDVKPSNILVNSNGEIKICDFGVSGQL-----IDSMANSFVGTRSYMSPERLQGTHYSV 264
HRD+K +NIL +S G +K+ DFG S +L + S GT +MSPE + G Y
Sbjct: 483 HRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGR 542
Query: 265 QSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPN 311
++D+WSLG ++VEM + P P + + +AAIF + +P Q P+
Sbjct: 543 KADVWSLGCTVVEM-LTEKP-PWAEYEAMAAIFKIATQPTNP-QLPS 586
>BC093674-1|AAH93674.1| 626|Homo sapiens mitogen-activated protein
kinase kinase kinase 3, isoform 2 protein.
Length = 626
Score = 111 bits (266), Expect = 6e-24
Identities = 80/227 (35%), Positives = 120/227 (52%), Gaps = 15/227 (6%)
Query: 96 LGQGNGGVVMKVRHKSTGLIMARKLIHLEV-KPAIKKQIIR---ELKVLHECNFAHIVGF 151
LGQG G V TG +A K + + P K++ E+++L IV +
Sbjct: 368 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQY 427
Query: 152 YGAFYSDGE--ISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAIM 209
YG E ++I MEYM GGS+ LK G + ES+ T +L+G+SYL + I+
Sbjct: 428 YGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHS-NMIV 486
Query: 210 HRDVKPSNILVNSNGEIKICDFGVSGQL-----IDSMANSFVGTRSYMSPERLQGTHYSV 264
HRD+K +NIL +S G +K+ DFG S +L + S GT +MSPE + G Y
Sbjct: 487 HRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGR 546
Query: 265 QSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPN 311
++D+WSLG ++VEM + P P + + +AAIF + +P Q P+
Sbjct: 547 KADVWSLGCTVVEM-LTEKP-PWAEYEAMAAIFKIATQPTNP-QLPS 590
>BC093672-1|AAH93672.1| 626|Homo sapiens mitogen-activated protein
kinase kinase kinase 3, isoform 2 protein.
Length = 626
Score = 111 bits (266), Expect = 6e-24
Identities = 80/227 (35%), Positives = 120/227 (52%), Gaps = 15/227 (6%)
Query: 96 LGQGNGGVVMKVRHKSTGLIMARKLIHLEV-KPAIKKQIIR---ELKVLHECNFAHIVGF 151
LGQG G V TG +A K + + P K++ E+++L IV +
Sbjct: 368 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQY 427
Query: 152 YGAFYSDGE--ISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAIM 209
YG E ++I MEYM GGS+ LK G + ES+ T +L+G+SYL + I+
Sbjct: 428 YGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHS-NMIV 486
Query: 210 HRDVKPSNILVNSNGEIKICDFGVSGQL-----IDSMANSFVGTRSYMSPERLQGTHYSV 264
HRD+K +NIL +S G +K+ DFG S +L + S GT +MSPE + G Y
Sbjct: 487 HRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGR 546
Query: 265 QSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPN 311
++D+WSLG ++VEM + P P + + +AAIF + +P Q P+
Sbjct: 547 KADVWSLGCTVVEM-LTEKP-PWAEYEAMAAIFKIATQPTNP-QLPS 590
>BC090859-1|AAH90859.1| 626|Homo sapiens mitogen-activated protein
kinase kinase kinase 3 protein.
Length = 626
Score = 111 bits (266), Expect = 6e-24
Identities = 80/227 (35%), Positives = 120/227 (52%), Gaps = 15/227 (6%)
Query: 96 LGQGNGGVVMKVRHKSTGLIMARKLIHLEV-KPAIKKQIIR---ELKVLHECNFAHIVGF 151
LGQG G V TG +A K + + P K++ E+++L IV +
Sbjct: 368 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQY 427
Query: 152 YGAFYSDGE--ISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAIM 209
YG E ++I MEYM GGS+ LK G + ES+ T +L+G+SYL + I+
Sbjct: 428 YGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHS-NMIV 486
Query: 210 HRDVKPSNILVNSNGEIKICDFGVSGQL-----IDSMANSFVGTRSYMSPERLQGTHYSV 264
HRD+K +NIL +S G +K+ DFG S +L + S GT +MSPE + G Y
Sbjct: 487 HRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGR 546
Query: 265 QSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPN 311
++D+WSLG ++VEM + P P + + +AAIF + +P Q P+
Sbjct: 547 KADVWSLGCTVVEM-LTEKP-PWAEYEAMAAIFKIATQPTNP-QLPS 590
>BC008336-1|AAH08336.1| 594|Homo sapiens Unknown (protein for
IMAGE:3506235) protein.
Length = 594
Score = 111 bits (266), Expect = 6e-24
Identities = 80/227 (35%), Positives = 120/227 (52%), Gaps = 15/227 (6%)
Query: 96 LGQGNGGVVMKVRHKSTGLIMARKLIHLEV-KPAIKKQIIR---ELKVLHECNFAHIVGF 151
LGQG G V TG +A K + + P K++ E+++L IV +
Sbjct: 336 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQY 395
Query: 152 YGAFYSDGE--ISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAIM 209
YG E ++I MEYM GGS+ LK G + ES+ T +L+G+SYL + I+
Sbjct: 396 YGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHS-NMIV 454
Query: 210 HRDVKPSNILVNSNGEIKICDFGVSGQL-----IDSMANSFVGTRSYMSPERLQGTHYSV 264
HRD+K +NIL +S G +K+ DFG S +L + S GT +MSPE + G Y
Sbjct: 455 HRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGR 514
Query: 265 QSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPN 311
++D+WSLG ++VEM + P P + + +AAIF + +P Q P+
Sbjct: 515 KADVWSLGCTVVEM-LTEKP-PWAEYEAMAAIFKIATQPTNP-QLPS 558
>AB072828-1|BAC15599.1| 489|Homo sapiens NIMA-related protein
kinase 3 protein.
Length = 489
Score = 110 bits (265), Expect = 7e-24
Identities = 68/210 (32%), Positives = 115/210 (54%), Gaps = 5/210 (2%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAH 147
DD+ L +G+G G + V+H+S+ + A K I L + + +E +L + +
Sbjct: 2 DDYMVLRMIGEGFFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPN 61
Query: 148 IVGFYGAFYSDGEISICMEYMDGGSL-DLILKKAGRI-PESILGTITSAVLKGLSYLRDK 205
IV F +F ++G + I MEY DGG L I ++ G++ PE ++ + + G++++ K
Sbjct: 62 IVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKK 121
Query: 206 HAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYS 263
++HRD+K NI + NG++K+ DFG + L + M A ++VGT Y+ PE + Y+
Sbjct: 122 R-VLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN 180
Query: 264 VQSDIWSLGLSLVEMAIGMYPIPPPDAKTL 293
+SDIWSLG L E+ +P K L
Sbjct: 181 NKSDIWSLGCILYELCTLKHPFQANSWKNL 210
>Z29066-1|CAA82309.1| 445|Homo sapiens protein kinase protein.
Length = 445
Score = 110 bits (264), Expect = 1e-23
Identities = 73/220 (33%), Positives = 117/220 (53%), Gaps = 13/220 (5%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMA-RKLIHLEVKPAIKKQIIRELKVLHECNFA 146
+D+E L +G G+ G K+R KS G I+ ++L + + A K+ ++ E+ +L E
Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65
Query: 147 HIVGFYGAFY--SDGEISICMEYMDGGSLDLILKKAGRI-----PESILGTIT--SAVLK 197
+IV +Y ++ + I MEY +GG L ++ K + E +L +T + LK
Sbjct: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125
Query: 198 GLSYLRDK-HAIMHRDVKPSNILVNSNGEIKICDFGVSGQLID--SMANSFVGTRSYMSP 254
D H ++HRD+KP+N+ ++ +K+ DFG++ L S A +FVGT YMSP
Sbjct: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSP 185
Query: 255 ERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLA 294
E++ Y+ +SDIWSLG L E+ M P K LA
Sbjct: 186 EQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELA 225
>U11050-1|AAA19558.1| 445|Homo sapiens NIMA-like protein kinase 1
protein.
Length = 445
Score = 110 bits (264), Expect = 1e-23
Identities = 73/220 (33%), Positives = 117/220 (53%), Gaps = 13/220 (5%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMA-RKLIHLEVKPAIKKQIIRELKVLHECNFA 146
+D+E L +G G+ G K+R KS G I+ ++L + + A K+ ++ E+ +L E
Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65
Query: 147 HIVGFYGAFY--SDGEISICMEYMDGGSLDLILKKAGRI-----PESILGTIT--SAVLK 197
+IV +Y ++ + I MEY +GG L ++ K + E +L +T + LK
Sbjct: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125
Query: 198 GLSYLRDK-HAIMHRDVKPSNILVNSNGEIKICDFGVSGQLID--SMANSFVGTRSYMSP 254
D H ++HRD+KP+N+ ++ +K+ DFG++ L S A +FVGT YMSP
Sbjct: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSP 185
Query: 255 ERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLA 294
E++ Y+ +SDIWSLG L E+ M P K LA
Sbjct: 186 EQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELA 225
>L07598-1|AAC82496.1| 540|Homo sapiens ribosomal protein S6 kinase
2 protein.
Length = 540
Score = 110 bits (264), Expect = 1e-23
Identities = 73/230 (31%), Positives = 119/230 (51%), Gaps = 11/230 (4%)
Query: 70 RRIEVFLCQKEKIGELSDDDFEKLGELGQGNGG---VVMKVRHKSTGLIMARKLIH---L 123
+ I++ KE + FE L LGQG+ G +V KV+ G + A K++ L
Sbjct: 40 KEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATL 99
Query: 124 EVKPAIKKQIIRELKVLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRI 183
+V+ ++ ++ R+ +L E N IV + AF ++G++ + ++++ GG L L K
Sbjct: 100 KVRDRVRSKMERD--ILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMF 157
Query: 184 PESILGTITSAVLKGLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLI--DSM 241
E + + + L +L I++RD+KP NIL++ G IKI DFG+S + I D
Sbjct: 158 TEEDVKFYLAELALALDHLHSL-GIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKR 216
Query: 242 ANSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAK 291
A SF GT YM+PE + ++ +D WS G+ + EM G P D K
Sbjct: 217 AYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGALPFQGKDRK 266
Score = 45.6 bits (103), Expect = 3e-04
Identities = 39/134 (29%), Positives = 63/134 (47%), Gaps = 9/134 (6%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAH 147
D +E ++G G+ V + HK+T A K+I K+ E+++L
Sbjct: 414 DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIGKS-----KRDPSEEIEILLRYGQHP 468
Query: 148 IVGFYGAFYSDGE-ISICMEYMDGGSL-DLILKKAGRIPESILGTITSAVLKGLSYLRDK 205
+ Y DG+ + + ME M GG L D IL++ E + + K + YL +
Sbjct: 469 NIITLKDVYDDGKFVYLVMELMRGGELLDRILRQR-YFSEREASDVLCTITKTMDYLHSQ 527
Query: 206 HAIMHRDVKPSNIL 219
++HRD+KPSNIL
Sbjct: 528 -GVVHRDLKPSNIL 540
>BT019729-1|AAV38534.1| 445|Homo sapiens NIMA (never in mitosis
gene a)-related kinase 2 protein.
Length = 445
Score = 110 bits (264), Expect = 1e-23
Identities = 73/220 (33%), Positives = 117/220 (53%), Gaps = 13/220 (5%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMA-RKLIHLEVKPAIKKQIIRELKVLHECNFA 146
+D+E L +G G+ G K+R KS G I+ ++L + + A K+ ++ E+ +L E
Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65
Query: 147 HIVGFYGAFY--SDGEISICMEYMDGGSLDLILKKAGRI-----PESILGTIT--SAVLK 197
+IV +Y ++ + I MEY +GG L ++ K + E +L +T + LK
Sbjct: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125
Query: 198 GLSYLRDK-HAIMHRDVKPSNILVNSNGEIKICDFGVSGQLID--SMANSFVGTRSYMSP 254
D H ++HRD+KP+N+ ++ +K+ DFG++ L S A +FVGT YMSP
Sbjct: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSP 185
Query: 255 ERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLA 294
E++ Y+ +SDIWSLG L E+ M P K LA
Sbjct: 186 EQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELA 225
>BC052807-1|AAH52807.1| 326|Homo sapiens NEK2 protein protein.
Length = 326
Score = 110 bits (264), Expect = 1e-23
Identities = 73/220 (33%), Positives = 117/220 (53%), Gaps = 13/220 (5%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMA-RKLIHLEVKPAIKKQIIRELKVLHECNFA 146
+D+E L +G G+ G K+R KS G I+ ++L + + A K+ ++ E+ +L E
Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65
Query: 147 HIVGFYGAFY--SDGEISICMEYMDGGSLDLILKKAGRI-----PESILGTIT--SAVLK 197
+IV +Y ++ + I MEY +GG L ++ K + E +L +T + LK
Sbjct: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125
Query: 198 GLSYLRDK-HAIMHRDVKPSNILVNSNGEIKICDFGVSGQLID--SMANSFVGTRSYMSP 254
D H ++HRD+KP+N+ ++ +K+ DFG++ L S A +FVGT YMSP
Sbjct: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSP 185
Query: 255 ERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLA 294
E++ Y+ +SDIWSLG L E+ M P K LA
Sbjct: 186 EQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELA 225
>BC043502-1|AAH43502.2| 445|Homo sapiens NIMA (never in mitosis
gene a)-related kinase 2 protein.
Length = 445
Score = 110 bits (264), Expect = 1e-23
Identities = 73/220 (33%), Positives = 117/220 (53%), Gaps = 13/220 (5%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMA-RKLIHLEVKPAIKKQIIRELKVLHECNFA 146
+D+E L +G G+ G K+R KS G I+ ++L + + A K+ ++ E+ +L E
Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65
Query: 147 HIVGFYGAFY--SDGEISICMEYMDGGSLDLILKKAGRI-----PESILGTIT--SAVLK 197
+IV +Y ++ + I MEY +GG L ++ K + E +L +T + LK
Sbjct: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125
Query: 198 GLSYLRDK-HAIMHRDVKPSNILVNSNGEIKICDFGVSGQLID--SMANSFVGTRSYMSP 254
D H ++HRD+KP+N+ ++ +K+ DFG++ L S A +FVGT YMSP
Sbjct: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSP 185
Query: 255 ERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLA 294
E++ Y+ +SDIWSLG L E+ M P K LA
Sbjct: 186 EQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELA 225
>AY045701-1|AAK92212.1| 384|Homo sapiens NEK2B protein kinase
protein.
Length = 384
Score = 110 bits (264), Expect = 1e-23
Identities = 73/220 (33%), Positives = 117/220 (53%), Gaps = 13/220 (5%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMA-RKLIHLEVKPAIKKQIIRELKVLHECNFA 146
+D+E L +G G+ G K+R KS G I+ ++L + + A K+ ++ E+ +L E
Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65
Query: 147 HIVGFYGAFY--SDGEISICMEYMDGGSLDLILKKAGRI-----PESILGTIT--SAVLK 197
+IV +Y ++ + I MEY +GG L ++ K + E +L +T + LK
Sbjct: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125
Query: 198 GLSYLRDK-HAIMHRDVKPSNILVNSNGEIKICDFGVSGQLID--SMANSFVGTRSYMSP 254
D H ++HRD+KP+N+ ++ +K+ DFG++ L S A +FVGT YMSP
Sbjct: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSP 185
Query: 255 ERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLA 294
E++ Y+ +SDIWSLG L E+ M P K LA
Sbjct: 186 EQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELA 225
>AL356310-2|CAH72901.1| 445|Homo sapiens NIMA (never in mitosis
gene a)-related kinase 2 protein.
Length = 445
Score = 110 bits (264), Expect = 1e-23
Identities = 73/220 (33%), Positives = 117/220 (53%), Gaps = 13/220 (5%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMA-RKLIHLEVKPAIKKQIIRELKVLHECNFA 146
+D+E L +G G+ G K+R KS G I+ ++L + + A K+ ++ E+ +L E
Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65
Query: 147 HIVGFYGAFY--SDGEISICMEYMDGGSLDLILKKAGRI-----PESILGTIT--SAVLK 197
+IV +Y ++ + I MEY +GG L ++ K + E +L +T + LK
Sbjct: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125
Query: 198 GLSYLRDK-HAIMHRDVKPSNILVNSNGEIKICDFGVSGQLID--SMANSFVGTRSYMSP 254
D H ++HRD+KP+N+ ++ +K+ DFG++ L S A +FVGT YMSP
Sbjct: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSP 185
Query: 255 ERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLA 294
E++ Y+ +SDIWSLG L E+ M P K LA
Sbjct: 186 EQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELA 225
>AK223353-1|BAD97073.1| 445|Homo sapiens NIMA (never in mitosis
gene a)-related kinase 2 variant protein.
Length = 445
Score = 110 bits (264), Expect = 1e-23
Identities = 73/220 (33%), Positives = 117/220 (53%), Gaps = 13/220 (5%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMA-RKLIHLEVKPAIKKQIIRELKVLHECNFA 146
+D+E L +G G+ G K+R KS G I+ ++L + + A K+ ++ E+ +L E
Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65
Query: 147 HIVGFYGAFY--SDGEISICMEYMDGGSLDLILKKAGRI-----PESILGTIT--SAVLK 197
+IV +Y ++ + I MEY +GG L ++ K + E +L +T + LK
Sbjct: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125
Query: 198 GLSYLRDK-HAIMHRDVKPSNILVNSNGEIKICDFGVSGQLID--SMANSFVGTRSYMSP 254
D H ++HRD+KP+N+ ++ +K+ DFG++ L S A +FVGT YMSP
Sbjct: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSP 185
Query: 255 ERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLA 294
E++ Y+ +SDIWSLG L E+ M P K LA
Sbjct: 186 EQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELA 225
>BC109299-1|AAI09300.1| 545|Homo sapiens p21/Cdc42/Rac1-activated
kinase 1 (STE20 homolog, yeast) protein.
Length = 545
Score = 109 bits (263), Expect = 1e-23
Identities = 84/286 (29%), Positives = 142/286 (49%), Gaps = 32/286 (11%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
+ + ++GQG G V +TG +A K ++L+ +P K+ II E+ V+ E +IV
Sbjct: 270 YTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPK-KELIINEILVMRENKNPNIV 328
Query: 150 GFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAIM 209
+ ++ E+ + MEY+ GGSL ++ + + E + + L+ L +L I
Sbjct: 329 NYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALEFLHSNQVI- 386
Query: 210 HRDVKPSNILVNSNGEIKICDFGVSGQLI--DSMANSFVGTRSYMSPERLQGTHYSVQSD 267
HRD+K NIL+ +G +K+ DFG Q+ S ++ VGT +M+PE + Y + D
Sbjct: 387 HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVD 446
Query: 268 IWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIVN 327
IWSLG+ +EM G PP NE N R + +
Sbjct: 447 IWSLGIMAIEMIEG----EPPYL----------NE--------NPLRALYLIATNGTPEL 484
Query: 328 EPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAE 373
+ P KL S IF +DF++RCL+ + ++R K L+ H++++ A+
Sbjct: 485 QNPEKL-SAIF----RDFLNRCLEMDVEKRGSAKELLQHQFLKIAK 525
>AF099989-1|AAC72238.1| 547|Homo sapiens Ste-20 related kinase SPAK
protein.
Length = 547
Score = 109 bits (263), Expect = 1e-23
Identities = 67/213 (31%), Positives = 116/213 (54%), Gaps = 17/213 (7%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAH 147
D +E +G G VV K +A K I+LE ++++E++ + +C+ +
Sbjct: 63 DAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPN 122
Query: 148 IVGFYGAFYSDGEISICMEYMDGGSLDLILK--------KAGRIPESILGTITSAVLKGL 199
+V +Y +F E+ + M+ + GGS+ I+K K G + E+I+ TI VL+GL
Sbjct: 123 VVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGL 182
Query: 200 SYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLI-------DSMANSFVGTRSYM 252
YL ++ +HRD+K NIL+ +G ++I DFGVS L + + +FVGT +M
Sbjct: 183 DYLH-RNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWM 241
Query: 253 SPERLQGTH-YSVQSDIWSLGLSLVEMAIGMYP 284
+PE ++ Y ++D+WS G++ +E+A G P
Sbjct: 242 APEVMEQVRGYDFKADMWSFGITAIELATGAAP 274
>AC067940-1|AAY24032.1| 363|Homo sapiens unknown protein.
Length = 363
Score = 109 bits (263), Expect = 1e-23
Identities = 67/213 (31%), Positives = 116/213 (54%), Gaps = 17/213 (7%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAH 147
D +E +G G VV K +A K I+LE ++++E++ + +C+ +
Sbjct: 61 DAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPN 120
Query: 148 IVGFYGAFYSDGEISICMEYMDGGSLDLILK--------KAGRIPESILGTITSAVLKGL 199
+V +Y +F E+ + M+ + GGS+ I+K K G + E+I+ TI VL+GL
Sbjct: 121 VVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGL 180
Query: 200 SYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLI-------DSMANSFVGTRSYM 252
YL ++ +HRD+K NIL+ +G ++I DFGVS L + + +FVGT +M
Sbjct: 181 DYLH-RNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWM 239
Query: 253 SPERLQGTH-YSVQSDIWSLGLSLVEMAIGMYP 284
+PE ++ Y ++D+WS G++ +E+A G P
Sbjct: 240 APEVMEQVRGYDFKADMWSFGITAIELATGAAP 272
>AB062450-1|BAB85632.1| 302|Homo sapiens NEK7 protein.
Length = 302
Score = 109 bits (263), Expect = 1e-23
Identities = 80/275 (29%), Positives = 136/275 (49%), Gaps = 37/275 (13%)
Query: 95 ELGQGNGGVVMKVRHKSTGLIMARKLIHL-EVKPA-IKKQIIRELKVLHECNFAHIVGFY 152
++G+G V + G+ +A K + + ++ A + I+E+ +L + N +++ +Y
Sbjct: 39 KIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYY 98
Query: 153 GAFYSDGEISICMEYMDGGSLDLILK---KAGR-IPESILGTITSAVLKGLSYLRDKHAI 208
+F D E++I +E D G L ++K K R IPE + + L ++ + +
Sbjct: 99 ASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRR-V 157
Query: 209 MHRDVKPSNILVNSNGEIKICDFGVSGQLIDSM---ANSFVGTRSYMSPERLQGTHYSVQ 265
MHRD+KP+N+ + + G +K+ D G+ G+ S A+S VGT YMSPER+ Y+ +
Sbjct: 158 MHRDIKPANVFITATGVVKLGDLGL-GRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFK 216
Query: 266 SDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYI 325
SDIWSLG L EMA L + F G M ++ L I
Sbjct: 217 SDIWSLGCLLYEMA------------ALQSPFYGDK--------------MNLYSLCKKI 250
Query: 326 VNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADL 360
P LPS +S+E + V+ C+ +P++R D+
Sbjct: 251 EQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDV 285
>AF030403-1|AAD01901.1| 547|Homo sapiens Ste20-like protein kinase
protein.
Length = 547
Score = 109 bits (262), Expect = 2e-23
Identities = 67/213 (31%), Positives = 116/213 (54%), Gaps = 17/213 (7%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAH 147
D +E +G G VV K +A K I+LE ++++E++ + +C+ +
Sbjct: 63 DAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPN 122
Query: 148 IVGFYGAFYSDGEISICMEYMDGGSLDLILK--------KAGRIPESILGTITSAVLKGL 199
+V +Y +F E+ + M+ + GGS+ I+K K G + E+I+ TI VL+GL
Sbjct: 123 VVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATIFKEVLEGL 182
Query: 200 SYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLI-------DSMANSFVGTRSYM 252
YL ++ +HRD+K NIL+ +G ++I DFGVS L + + +FVGT +M
Sbjct: 183 DYLH-RNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWM 241
Query: 253 SPERLQGTH-YSVQSDIWSLGLSLVEMAIGMYP 284
+PE ++ Y ++D+WS G++ +E+A G P
Sbjct: 242 APEVMEQVRGYDFKADMWSFGITAIELATGAAP 274
>U24152-1|AAA65441.1| 545|Homo sapiens p21-activated protein kinase
protein.
Length = 545
Score = 109 bits (261), Expect = 2e-23
Identities = 84/286 (29%), Positives = 141/286 (49%), Gaps = 32/286 (11%)
Query: 90 FEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIV 149
+ + ++GQG G V +TG +A K ++L+ +P K+ II E+ V+ E +IV
Sbjct: 270 YTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPK-KELIINEILVMRENKNPNIV 328
Query: 150 GFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAIM 209
+ ++ E+ + MEY+ GGSL ++ + + E + + L+ L +L I
Sbjct: 329 NYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALEFLHSNQVI- 386
Query: 210 HRDVKPSNILVNSNGEIKICDFGVSGQLI--DSMANSFVGTRSYMSPERLQGTHYSVQSD 267
HRD+K NIL+ +G +K+ DFG Q+ S ++ VGT +M+PE + Y + D
Sbjct: 387 HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVD 446
Query: 268 IWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIVN 327
IWSLG+ +EM G PP NE N R + +
Sbjct: 447 IWSLGIMAIEMIEG----EPPYL----------NE--------NPLRALYLIATNGTPEL 484
Query: 328 EPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAE 373
+ P KL S IF +DF++RCL + ++R K L+ H++++ A+
Sbjct: 485 QNPEKL-SAIF----RDFLNRCLDMDVEKRGSAKELLQHQFLKIAK 525
>BT019534-1|AAV38341.1| 344|Homo sapiens serine/threonine kinase 12
protein.
Length = 344
Score = 109 bits (261), Expect = 2e-23
Identities = 81/285 (28%), Positives = 130/285 (45%), Gaps = 33/285 (11%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEV--KPAIKKQIIRELKVLHECNF 145
DDFE LG+G G V R K + I+A K++ K ++ Q+ RE+++ +
Sbjct: 75 DDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHH 134
Query: 146 AHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDK 205
+I+ Y FY I + +EY G L L+K+ E TI + L Y K
Sbjct: 135 PNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGK 194
Query: 206 HAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQ 265
I HRD+KP N+L+ GE+KI DFG S + GT Y+ PE ++G ++ +
Sbjct: 195 KVI-HRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEK 253
Query: 266 SDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYI 325
D+W +G+ E+ +G PP ++ NE + R + +L
Sbjct: 254 VDLWCIGVLCYELLVGN---PPFES-------ASHNETY---------RRIVKVDL---- 290
Query: 326 VNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIR 370
+ P +P+G +D + + L+ NP ER L + H W+R
Sbjct: 291 --KFPASVPTGA-----QDLISKLLRHNPSERLPLAQVSAHPWVR 328
>BC080581-1|AAH80581.1| 344|Homo sapiens aurora kinase B protein.
Length = 344
Score = 109 bits (261), Expect = 2e-23
Identities = 81/285 (28%), Positives = 130/285 (45%), Gaps = 33/285 (11%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEV--KPAIKKQIIRELKVLHECNF 145
DDFE LG+G G V R K + I+A K++ K ++ Q+ RE+++ +
Sbjct: 75 DDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHH 134
Query: 146 AHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDK 205
+I+ Y FY I + +EY G L L+K+ E TI + L Y K
Sbjct: 135 PNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGK 194
Query: 206 HAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQ 265
I HRD+KP N+L+ GE+KI DFG S + GT Y+ PE ++G ++ +
Sbjct: 195 KVI-HRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEK 253
Query: 266 SDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYI 325
D+W +G+ E+ +G PP ++ NE + R + +L
Sbjct: 254 VDLWCIGVLCYELLVGN---PPFES-------ASHNETY---------RRIVKVDL---- 290
Query: 326 VNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIR 370
+ P +P+G +D + + L+ NP ER L + H W+R
Sbjct: 291 --KFPASVPTGA-----QDLISKLLRHNPSERLPLAQVSAHPWVR 328
>BC000442-1|AAH00442.3| 344|Homo sapiens aurora kinase B protein.
Length = 344
Score = 109 bits (261), Expect = 2e-23
Identities = 81/285 (28%), Positives = 130/285 (45%), Gaps = 33/285 (11%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEV--KPAIKKQIIRELKVLHECNF 145
DDFE LG+G G V R K + I+A K++ K ++ Q+ RE+++ +
Sbjct: 75 DDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHH 134
Query: 146 AHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDK 205
+I+ Y FY I + +EY G L L+K+ E TI + L Y K
Sbjct: 135 PNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGK 194
Query: 206 HAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQ 265
I HRD+KP N+L+ GE+KI DFG S + GT Y+ PE ++G ++ +
Sbjct: 195 KVI-HRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEK 253
Query: 266 SDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYI 325
D+W +G+ E+ +G PP ++ NE + R + +L
Sbjct: 254 VDLWCIGVLCYELLVGN---PPFES-------ASHNETY---------RRIVKVDL---- 290
Query: 326 VNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIR 370
+ P +P+G +D + + L+ NP ER L + H W+R
Sbjct: 291 --KFPASVPTGA-----QDLISKLLRHNPSERLPLAQVSAHPWVR 328
>AF008552-1|AAC12709.1| 344|Homo sapiens aurora-related kinase 2
protein.
Length = 344
Score = 109 bits (261), Expect = 2e-23
Identities = 81/285 (28%), Positives = 130/285 (45%), Gaps = 33/285 (11%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEV--KPAIKKQIIRELKVLHECNF 145
DDFE LG+G G V R K + I+A K++ K ++ Q+ RE+++ +
Sbjct: 75 DDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHH 134
Query: 146 AHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDK 205
+I+ Y FY I + +EY G L L+K+ E TI + L Y K
Sbjct: 135 PNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGK 194
Query: 206 HAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQ 265
I HRD+KP N+L+ GE+KI DFG S + GT Y+ PE ++G ++ +
Sbjct: 195 KVI-HRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEK 253
Query: 266 SDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYI 325
D+W +G+ E+ +G PP ++ NE + R + +L
Sbjct: 254 VDLWCIGVLCYELLVGN---PPFES-------ASHNETY---------RRIVKVDL---- 290
Query: 326 VNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIR 370
+ P +P+G +D + + L+ NP ER L + H W+R
Sbjct: 291 --KFPASVPTGA-----QDLISKLLRHNPSERLPLAQVSAHPWVR 328
>AB011450-1|BAA32136.1| 344|Homo sapiens aurora and IPL1-like
midbody-associated protein kinase-1 protein.
Length = 344
Score = 109 bits (261), Expect = 2e-23
Identities = 81/285 (28%), Positives = 130/285 (45%), Gaps = 33/285 (11%)
Query: 88 DDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEV--KPAIKKQIIRELKVLHECNF 145
DDFE LG+G G V R K + I+A K++ K ++ Q+ RE+++ +
Sbjct: 75 DDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHH 134
Query: 146 AHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDK 205
+I+ Y FY I + +EY G L L+K+ E TI + L Y K
Sbjct: 135 PNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGK 194
Query: 206 HAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQ 265
I HRD+KP N+L+ GE+KI DFG S + GT Y+ PE ++G ++ +
Sbjct: 195 KVI-HRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEK 253
Query: 266 SDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYI 325
D+W +G+ E+ +G PP ++ NE + R + +L
Sbjct: 254 VDLWCIGVLCYELLVGN---PPFES-------ASHNETY---------RRIVKVDL---- 290
Query: 326 VNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIR 370
+ P +P+G +D + + L+ NP ER L + H W+R
Sbjct: 291 --KFPASVPTGA-----QDLISKLLRHNPSERLPLAQVSAHPWVR 328
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.316 0.134 0.391
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 63,666,921
Number of Sequences: 224733
Number of extensions: 2829800
Number of successful extensions: 16928
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 2164
Number of HSP's successfully gapped in prelim test: 600
Number of HSP's that attempted gapping in prelim test: 8840
Number of HSP's gapped (non-prelim): 4067
length of query: 403
length of database: 73,234,838
effective HSP length: 92
effective length of query: 311
effective length of database: 52,559,402
effective search space: 16345974022
effective search space used: 16345974022
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.6 bits)
S2: 66 (30.7 bits)
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