Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001401-TA|BGIBMGA001401-PA|IPR003000|Silent information
regulator protein Sir2
(370 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q9VH08 Cluster: CG6284-PA; n=9; Eumetazoa|Rep: CG6284-P... 389 e-107
UniRef50_Q8N6T7 Cluster: Mono-ADP-ribosyltransferase sirtuin-6; ... 314 3e-84
UniRef50_Q9FE17 Cluster: Sir2-like protein; n=9; Magnoliophyta|R... 256 9e-67
UniRef50_Q8N6T7-2 Cluster: Isoform 2 of Q8N6T7 ; n=5; Catarrhini... 255 1e-66
UniRef50_UPI0000E49846 Cluster: PREDICTED: similar to Sirtuin (s... 252 1e-65
UniRef50_A5AF92 Cluster: Putative uncharacterized protein; n=1; ... 200 5e-50
UniRef50_Q7SB01 Cluster: Putative uncharacterized protein NCU076... 165 2e-39
UniRef50_Q22KA8 Cluster: Transcriptional regulator, Sir2 family ... 165 2e-39
UniRef50_Q95Q89 Cluster: Yeast sir related protein 2.4; n=2; Cae... 161 3e-38
UniRef50_UPI0000D573CE Cluster: PREDICTED: similar to CG11305-PA... 160 5e-38
UniRef50_Q9NRC8 Cluster: NAD-dependent deacetylase sirtuin-7; n=... 155 1e-36
UniRef50_Q175I4 Cluster: Chromatin regulatory protein sir2; n=3;... 154 3e-36
UniRef50_UPI00015B56BB Cluster: PREDICTED: similar to ENSANGP000... 153 9e-36
UniRef50_A7AWG1 Cluster: Transcriptional regulator, Sir2 family ... 148 3e-34
UniRef50_Q9VAQ1 Cluster: CG11305-PA; n=8; Coelomata|Rep: CG11305... 144 2e-33
UniRef50_UPI00006CB0CC Cluster: transcriptional regulator, Sir2 ... 119 1e-25
UniRef50_Q2LSF2 Cluster: Sir2 family of NAD+-dependent deacetyla... 118 3e-25
UniRef50_Q9WYW0 Cluster: NAD-dependent deacetylase; n=4; Thermot... 105 2e-21
UniRef50_Q89LY4 Cluster: NAD-dependent deacetylase 1; n=12; Prot... 104 4e-21
UniRef50_Q974M6 Cluster: NAD-dependent deacetylase; n=8; Thermop... 102 1e-20
UniRef50_A0NQ49 Cluster: Silent information regulator protein Si... 98 4e-19
UniRef50_Q4UH74 Cluster: Sir2-like histone deacetylase, putative... 97 6e-19
UniRef50_Q73KE1 Cluster: NAD-dependent deacetylase; n=1; Trepone... 97 9e-19
UniRef50_A3ZMQ7 Cluster: Sir2 family, possible ADP ribosyltransf... 95 3e-18
UniRef50_Q8ZU41 Cluster: NAD-dependent deacetylase 1; n=3; Pyrob... 95 3e-18
UniRef50_A6DC77 Cluster: Silent information regulator protein Si... 94 5e-18
UniRef50_Q8ZT00 Cluster: NAD-dependent deacetylase 2; n=2; cellu... 94 5e-18
UniRef50_A6P1S7 Cluster: Putative uncharacterized protein; n=2; ... 94 6e-18
UniRef50_A5K3P4 Cluster: Putative uncharacterized protein; n=1; ... 94 6e-18
UniRef50_Q67KQ0 Cluster: NAD-dependent deacetylase; n=1; Symbiob... 94 6e-18
UniRef50_Q8N6T7-3 Cluster: Isoform 3 of Q8N6T7 ; n=2; Catarrhini... 91 4e-17
UniRef50_Q12Y78 Cluster: Silent information regulator protein Si... 91 6e-17
UniRef50_Q5L014 Cluster: NAD-dependent deacetylase 1; n=7; Bacil... 90 7e-17
UniRef50_Q5YR82 Cluster: Putative Sir2 family regulator; n=1; No... 89 2e-16
UniRef50_A4J646 Cluster: Silent information regulator protein Si... 87 5e-16
UniRef50_Q8IKW2 Cluster: Putative uncharacterized protein; n=1; ... 87 5e-16
UniRef50_Q7RP35 Cluster: Sir2-like protein; n=5; Plasmodium (Vin... 87 5e-16
UniRef50_Q8CJM9 Cluster: NAD-dependent deacetylase 2; n=3; Actin... 87 7e-16
UniRef50_A1HLU5 Cluster: Silent information regulator protein Si... 86 1e-15
UniRef50_A7HL19 Cluster: Silent information regulator protein Si... 85 2e-15
UniRef50_A1HU63 Cluster: Silent information regulator protein Si... 85 2e-15
UniRef50_Q97MB4 Cluster: NAD-dependent deacetylase; n=7; Bacteri... 85 2e-15
UniRef50_A5UYK2 Cluster: Silent information regulator protein Si... 85 4e-15
UniRef50_UPI000049979A Cluster: Sir2 family transcriptional regu... 83 1e-14
UniRef50_Q3F1F4 Cluster: SIR2 family protein; n=1; Bacillus thur... 82 3e-14
UniRef50_Q1MT39 Cluster: Novel protein similar to vertebratesirt... 81 3e-14
UniRef50_Q2YZT2 Cluster: Putative uncharacterized protein; n=1; ... 81 3e-14
UniRef50_Q8U1Q1 Cluster: NAD-dependent deacetylase; n=19; cellul... 81 6e-14
UniRef50_A6PTK3 Cluster: Silent information regulator protein Si... 80 1e-13
UniRef50_A7B9E8 Cluster: Putative uncharacterized protein; n=1; ... 79 1e-13
UniRef50_A4VDQ9 Cluster: Chromatin regulatory protein sir2; n=1;... 79 2e-13
UniRef50_A4M603 Cluster: Silent information regulator protein Si... 78 3e-13
UniRef50_A6LP94 Cluster: Silent information regulator protein Si... 78 4e-13
UniRef50_O94066 Cluster: Transcription regulatory protein; n=6; ... 75 2e-12
UniRef50_Q86ED3 Cluster: Clone ZZD513 mRNA sequence; n=2; Schist... 75 3e-12
UniRef50_O07595 Cluster: NAD-dependent deacetylase; n=3; Bacillu... 75 3e-12
UniRef50_Q8R984 Cluster: NAD-dependent deacetylase 2; n=1; Therm... 75 4e-12
UniRef50_UPI000049971A Cluster: Sir2 family transcriptional regu... 74 5e-12
UniRef50_Q899G3 Cluster: NAD-dependent deacetylase; n=19; cellul... 74 5e-12
UniRef50_A7DQD6 Cluster: Silent information regulator protein Si... 74 7e-12
UniRef50_Q88BY5 Cluster: NAD-dependent deacetylase; n=9; Bacteri... 73 9e-12
UniRef50_A1CD03 Cluster: SIR2 family histone deacetylase, putati... 71 5e-11
UniRef50_Q23E36 Cluster: Transcriptional regulator, Sir2 family ... 71 6e-11
UniRef50_Q0R0H8 Cluster: Sir2-like protein; n=1; Naegleria sp. T... 68 3e-10
UniRef50_A2QFF9 Cluster: Complex: Sir2p is one of four Silent In... 68 3e-10
UniRef50_A6TNA0 Cluster: Silent information regulator protein Si... 67 6e-10
UniRef50_Q9USN7 Cluster: Sir2 family histone deacetylase Hst2; n... 67 6e-10
UniRef50_Q8CNF4 Cluster: NAD-dependent deacetylase; n=17; Staphy... 67 6e-10
UniRef50_Q9I4L0 Cluster: NAD-dependent deacetylase 1; n=10; Bact... 67 6e-10
UniRef50_A4QUX8 Cluster: Putative uncharacterized protein; n=1; ... 66 1e-09
UniRef50_A1DG07 Cluster: SIR2 family histone deacetylase, putati... 66 1e-09
UniRef50_A2F9H1 Cluster: Transcriptional regulator, Sir2 family ... 66 2e-09
UniRef50_Q750H1 Cluster: AGL018Cp; n=1; Eremothecium gossypii|Re... 66 2e-09
UniRef50_Q3E2I1 Cluster: Silent information regulator protein Si... 65 2e-09
UniRef50_Q7SCL4 Cluster: Putative uncharacterized protein NCU005... 65 2e-09
UniRef50_UPI00004997CB Cluster: Sir2 family transcriptional regu... 65 3e-09
UniRef50_Q5KDE0 Cluster: NAD-dependent histone deacetylase, puta... 64 4e-09
UniRef50_UPI0000519F58 Cluster: PREDICTED: similar to Sirt4 CG31... 63 1e-08
UniRef50_A1I9S7 Cluster: NAD-dependent deacetylase; n=1; Candida... 63 1e-08
UniRef50_UPI00006CA40C Cluster: transcriptional regulator, Sir2 ... 63 1e-08
UniRef50_Q8Y015 Cluster: NAD-dependent deacetylase; n=11; Bacter... 63 1e-08
UniRef50_Q54QE6 Cluster: Zn finger-containing protein; n=5; Euka... 62 2e-08
UniRef50_Q8REC3 Cluster: NAD-dependent deacetylase; n=3; Fusobac... 62 2e-08
UniRef50_UPI0000E49AD8 Cluster: PREDICTED: similar to NAD-depend... 62 3e-08
UniRef50_Q8F3Z6 Cluster: NAD-dependent deacetylase; n=4; Leptosp... 62 3e-08
UniRef50_Q5V4Q5 Cluster: NAD-dependent deacetylase; n=2; Halobac... 62 3e-08
UniRef50_Q9NTG7 Cluster: NAD-dependent deacetylase sirtuin-3, mi... 61 4e-08
UniRef50_Q4WFZ3 Cluster: SIR2 family histone deacetylase, putati... 61 5e-08
UniRef50_Q607X6 Cluster: NAD-dependent deacetylase; n=1; Methylo... 61 5e-08
UniRef50_Q1D737 Cluster: NAD-dependent deacetylase; n=1; Myxococ... 60 7e-08
UniRef50_Q3A6W7 Cluster: NAD-dependent protein deacetylases, SIR... 60 9e-08
UniRef50_A0LG97 Cluster: Silent information regulator protein Si... 60 9e-08
UniRef50_Q8R104 Cluster: NAD-dependent deacetylase sirtuin-3; n=... 60 9e-08
UniRef50_A1ZPG8 Cluster: NAD-dependent deacetylase; n=1; Microsc... 60 1e-07
UniRef50_A0C2R2 Cluster: Chromosome undetermined scaffold_145, w... 60 1e-07
UniRef50_A1FG80 Cluster: Silent information regulator protein Si... 59 2e-07
UniRef50_A6RXY5 Cluster: Putative uncharacterized protein; n=2; ... 59 2e-07
UniRef50_Q8G465 Cluster: Sir2-type regulatory protein; n=2; Bifi... 59 2e-07
UniRef50_Q54GV7 Cluster: NAD(+)-dependent deacetylase, silent in... 59 2e-07
UniRef50_A7EC18 Cluster: Putative uncharacterized protein; n=1; ... 58 3e-07
UniRef50_Q07FY7 Cluster: Sirtuin (Silent mating type information... 58 5e-07
UniRef50_Q25337 Cluster: NAD-dependent deacetylase SIR2 homolog;... 58 5e-07
UniRef50_A7SX90 Cluster: Predicted protein; n=3; Eumetazoa|Rep: ... 57 8e-07
UniRef50_Q5KZE8 Cluster: NAD-dependent deacetylase 2; n=3; Bacte... 56 1e-06
UniRef50_Q4S7H2 Cluster: Chromosome 13 SCAF14715, whole genome s... 56 2e-06
UniRef50_Q0AY57 Cluster: Regulatory protein, sir2 family; n=1; S... 56 2e-06
UniRef50_A1A3R7 Cluster: Sir2-type regulatory protein; n=2; Bifi... 56 2e-06
UniRef50_A2DP91 Cluster: Transcriptional regulator, Sir2 family ... 56 2e-06
UniRef50_Q96EB6 Cluster: NAD-dependent deacetylase sirtuin-1; n=... 56 2e-06
UniRef50_O59923 Cluster: NAD-dependent histone deacetylase SIR2;... 56 2e-06
UniRef50_Q298C7 Cluster: GA18650-PA; n=1; Drosophila pseudoobscu... 55 3e-06
UniRef50_A7EMW8 Cluster: Putative uncharacterized protein; n=1; ... 55 3e-06
UniRef50_A2DKF0 Cluster: Transcriptional regulator, Sir2 family ... 55 3e-06
UniRef50_A6WG46 Cluster: Silent information regulator protein Si... 54 5e-06
UniRef50_Q81NT6 Cluster: NAD-dependent deacetylase; n=11; Bacill... 54 5e-06
UniRef50_Q6BVM7 Cluster: Similar to CA4170|IPF7784 Candida albic... 54 6e-06
UniRef50_Q6BPH5 Cluster: Debaryomyces hansenii chromosome E of s... 54 6e-06
UniRef50_A2Q9C4 Cluster: Contig An01c0250, complete genome; n=18... 54 6e-06
UniRef50_Q885X7 Cluster: NAD-dependent deacetylase 2; n=4; Pseud... 54 6e-06
UniRef50_Q8FRV5 Cluster: NAD-dependent deacetylase 2; n=9; Coryn... 54 6e-06
UniRef50_Q0LIC7 Cluster: Silent information regulator protein Si... 54 8e-06
UniRef50_Q8SSB6 Cluster: SIR2-LIKE PROTEIN INVOLVED IN TELOMERIC... 53 1e-05
UniRef50_A7SK95 Cluster: Predicted protein; n=1; Nematostella ve... 53 1e-05
UniRef50_A5K7T7 Cluster: NAD-dependent deacetylase, putative; n=... 53 1e-05
UniRef50_A4RCT8 Cluster: Putative uncharacterized protein; n=3; ... 53 1e-05
UniRef50_Q046W9 Cluster: NAD-dependent protein deacetylase, SIR2... 52 2e-05
UniRef50_Q011Q8 Cluster: NAD-dependent deacetylase SIRT2; n=2; O... 52 2e-05
UniRef50_Q1RL71 Cluster: Zinc finger protein; n=2; Ciona intesti... 52 2e-05
UniRef50_A2F8N6 Cluster: Transcriptional regulator, Sir2 family ... 52 2e-05
UniRef50_A2F8E1 Cluster: Transcriptional regulator, Sir2 family ... 52 2e-05
UniRef50_A0C6J0 Cluster: Chromosome undetermined scaffold_152, w... 52 2e-05
UniRef50_Q8FUC8 Cluster: NAD-dependent deacetylase 1; n=6; Coryn... 52 2e-05
UniRef50_Q839C6 Cluster: NAD-dependent deacetylase; n=14; Bacill... 52 2e-05
UniRef50_P53686 Cluster: NAD-dependent deacetylase HST2; n=4; Sa... 52 2e-05
UniRef50_Q6AF12 Cluster: Regulatory protein, Sir2 family; n=2; A... 52 3e-05
UniRef50_A6RRE3 Cluster: Putative uncharacterized protein; n=1; ... 52 3e-05
UniRef50_A5DSX8 Cluster: NAD-dependent histone deacetylase SIR2;... 52 3e-05
UniRef50_A3LN35 Cluster: NAD-dependent histone deacetylase SIR2;... 52 3e-05
UniRef50_UPI00015B4FA0 Cluster: PREDICTED: similar to chromatin ... 51 4e-05
UniRef50_A5WD15 Cluster: Silent information regulator protein Si... 51 4e-05
UniRef50_Q2H5A0 Cluster: Putative uncharacterized protein; n=1; ... 51 4e-05
UniRef50_Q88ZA0 Cluster: NAD-dependent deacetylase; n=4; Lactoba... 51 4e-05
UniRef50_UPI0000499DEA Cluster: Sir2 family transcriptional regu... 51 6e-05
UniRef50_Q0UNC9 Cluster: Putative uncharacterized protein; n=1; ... 51 6e-05
UniRef50_A5DNV7 Cluster: Putative uncharacterized protein; n=1; ... 51 6e-05
UniRef50_Q9FY91 Cluster: SIR2-family protein; n=12; Magnoliophyt... 50 7e-05
UniRef50_Q7S6G9 Cluster: Putative uncharacterized protein NCU047... 50 7e-05
UniRef50_Q8IRR5 Cluster: CG3187-PC, isoform C; n=4; Diptera|Rep:... 50 1e-04
UniRef50_Q22ZC3 Cluster: Transcriptional regulator, Sir2 family ... 50 1e-04
UniRef50_Q6ZMU6 Cluster: CDNA FLJ16662 fis, clone TESTI4046240, ... 50 1e-04
UniRef50_Q6FKU1 Cluster: Similar to sp|P53686 Saccharomyces cere... 50 1e-04
UniRef50_Q6C219 Cluster: Yarrowia lipolytica chromosome F of str... 50 1e-04
UniRef50_Q0CR31 Cluster: NAD-dependent histone deacetylase SIR2;... 50 1e-04
UniRef50_A6G0H3 Cluster: Silent information regulator protein Si... 50 1e-04
UniRef50_Q6C8C7 Cluster: Similar to DEHA0C01507g Debaryomyces ha... 50 1e-04
UniRef50_A4QX96 Cluster: Putative uncharacterized protein; n=2; ... 50 1e-04
UniRef50_UPI00015B57C0 Cluster: PREDICTED: similar to GA18743-PA... 49 2e-04
UniRef50_Q5KA61 Cluster: Histone deacetylase, putative; n=1; Fil... 49 2e-04
UniRef50_A5DJ74 Cluster: Putative uncharacterized protein; n=1; ... 49 2e-04
UniRef50_Q21921 Cluster: NAD-dependent deacetylase SIR2 homolog;... 49 2e-04
UniRef50_A1CTI6 Cluster: SIR2 family histone deacetylase, putati... 48 3e-04
UniRef50_O94640 Cluster: NAD-dependent histone deacetylase sir2;... 48 3e-04
UniRef50_Q21KQ1 Cluster: Silent information regulator protein Si... 48 4e-04
UniRef50_A3LRA1 Cluster: Transcriptional regulatory protein; n=2... 48 4e-04
UniRef50_Q9I4E1 Cluster: NAD-dependent deacetylase 2; n=6; Pseud... 48 5e-04
UniRef50_A6R1B0 Cluster: Predicted protein; n=2; Onygenales|Rep:... 47 7e-04
UniRef50_Q7QZ36 Cluster: GLP_464_21655_23334; n=1; Giardia lambl... 47 0.001
UniRef50_Q4DP02 Cluster: Silent information regulator 2, putativ... 47 0.001
UniRef50_O96505 Cluster: SIR2; n=4; Sophophora|Rep: SIR2 - Droso... 47 0.001
UniRef50_A2GAR7 Cluster: Transcriptional regulator, Sir2 family ... 47 0.001
UniRef50_Q5AQ47 Cluster: Potential Sir2 family histone deacetyla... 47 0.001
UniRef50_Q8R216 Cluster: NAD-dependent deacetylase sirtuin-4; n=... 47 0.001
UniRef50_Q89EA6 Cluster: NAD-dependent deacetylase 2; n=9; Prote... 47 0.001
UniRef50_Q1D9X2 Cluster: Sir2 family protein; n=1; Myxococcus xa... 46 0.001
UniRef50_Q23A43 Cluster: Transcriptional regulator, Sir2 family ... 46 0.001
UniRef50_Q1RPU3 Cluster: Zinc finger protein; n=1; Ciona intesti... 46 0.001
UniRef50_A0D0F1 Cluster: Chromosome undetermined scaffold_33, wh... 46 0.001
UniRef50_UPI0000D578DC Cluster: PREDICTED: similar to sirtuin 5 ... 46 0.002
UniRef50_A6DES9 Cluster: Transcriptional regulator, Sir2 family ... 46 0.002
UniRef50_A3JEV2 Cluster: NAD-dependent deacetylase; n=2; Marinob... 46 0.002
UniRef50_A0PU12 Cluster: Sir2-like regulatory protein; n=1; Myco... 46 0.002
UniRef50_Q2GZ88 Cluster: Putative uncharacterized protein; n=1; ... 46 0.002
UniRef50_Q9Y6E7 Cluster: NAD-dependent deacetylase sirtuin-4; n=... 46 0.002
UniRef50_Q5BVF7 Cluster: SJCHGC03105 protein; n=2; Schistosoma j... 46 0.002
UniRef50_Q4WET3 Cluster: SIR2 family histone deacetylase, putati... 46 0.002
UniRef50_UPI0000D55B5A Cluster: PREDICTED: similar to CG5216-PA;... 45 0.004
UniRef50_UPI000051AA14 Cluster: PREDICTED: similar to NAD-depend... 45 0.004
UniRef50_Q1YSP9 Cluster: NAD-dependent deacetylase; n=1; gamma p... 45 0.004
UniRef50_Q03ZB1 Cluster: NAD-dependent protein deacetylase, SIR2... 45 0.004
UniRef50_Q7S386 Cluster: Putative uncharacterized protein NCU048... 45 0.004
UniRef50_Q6CB00 Cluster: Similarities with tr|Q9UR39 Schizosacch... 45 0.004
UniRef50_A6RSV6 Cluster: Putative uncharacterized protein; n=2; ... 45 0.004
UniRef50_A7RMK8 Cluster: Predicted protein; n=5; Eumetazoa|Rep: ... 44 0.005
UniRef50_Q6CQA7 Cluster: Kluyveromyces lactis strain NRRL Y-1140... 44 0.005
UniRef50_A7TQE2 Cluster: Putative uncharacterized protein; n=1; ... 44 0.005
UniRef50_Q8IXJ6 Cluster: NAD-dependent deacetylase sirtuin-2; n=... 44 0.005
UniRef50_UPI000023F1DF Cluster: hypothetical protein FG02466.1; ... 44 0.006
UniRef50_A4JS80 Cluster: Silent information regulator protein Si... 44 0.006
UniRef50_Q7R0G2 Cluster: GLP_29_33086_34261; n=1; Giardia lambli... 44 0.006
UniRef50_Q54P49 Cluster: Zn finger-containing protein; n=1; Dict... 44 0.006
UniRef50_A7RLD5 Cluster: Predicted protein; n=1; Nematostella ve... 44 0.006
UniRef50_Q4WT50 Cluster: SIR2 family histone deacetylase (Hst4),... 44 0.006
UniRef50_P53688 Cluster: NAD-dependent histone deacetylase HST4;... 44 0.006
UniRef50_Q4APN6 Cluster: Silent information regulator protein Si... 44 0.008
UniRef50_Q7PS76 Cluster: ENSANGP00000025231; n=1; Anopheles gamb... 44 0.008
UniRef50_Q7ZVK3 Cluster: NAD-dependent deacetylase sirtuin-2; n=... 44 0.008
UniRef50_Q9RL35 Cluster: NAD-dependent deacetylase 1; n=8; Actin... 44 0.008
UniRef50_Q1QTH0 Cluster: Silent information regulator protein Si... 43 0.011
UniRef50_A4A8B4 Cluster: Silent information regulator protein Si... 43 0.011
UniRef50_Q0UMU7 Cluster: Putative uncharacterized protein; n=1; ... 43 0.015
UniRef50_Q882K4 Cluster: NAD-dependent deacetylase 3; n=5; Pseud... 43 0.015
UniRef50_Q9UR39 Cluster: NAD-dependent deacetylase hst4; n=1; Sc... 43 0.015
UniRef50_Q0LFI4 Cluster: Silent information regulator protein Si... 42 0.019
UniRef50_Q6C8V5 Cluster: Similar to tr|Q9FY91 Arabidopsis thalia... 42 0.019
UniRef50_Q6BPA4 Cluster: Debaryomyces hansenii chromosome E of s... 42 0.019
UniRef50_A4RMS1 Cluster: Putative uncharacterized protein; n=2; ... 42 0.019
UniRef50_Q5KPC9 Cluster: Hst3 protein, putative; n=2; Filobasidi... 42 0.026
UniRef50_Q4PG00 Cluster: Putative uncharacterized protein; n=1; ... 42 0.026
UniRef50_A6SP88 Cluster: Putative uncharacterized protein; n=2; ... 42 0.026
UniRef50_Q9NXA8 Cluster: NAD-dependent deacetylase sirtuin-5; n=... 42 0.026
UniRef50_Q9CBW6 Cluster: NAD-dependent deacetylase; n=14; Mycoba... 42 0.026
UniRef50_Q5P3W1 Cluster: NAD-dependent deacetylase 2; n=4; Prote... 42 0.034
UniRef50_A6Q2C0 Cluster: Transcriptional regulator, Sir2 family;... 42 0.034
UniRef50_A4JJP4 Cluster: Silent information regulator protein Si... 42 0.034
UniRef50_Q7JMD3 Cluster: Putative uncharacterized protein sir-2.... 42 0.034
UniRef50_Q4QB33 Cluster: Sir2-family protein-like protein; n=4; ... 42 0.034
UniRef50_Q7S223 Cluster: Putative uncharacterized protein NCU059... 42 0.034
UniRef50_Q55DB0 Cluster: NAD(+)-dependent deacetylase, silent in... 41 0.045
UniRef50_Q875P9 Cluster: HST1; n=1; Lachancea kluyveri|Rep: HST1... 41 0.045
UniRef50_Q4P1X1 Cluster: Putative uncharacterized protein; n=1; ... 41 0.045
UniRef50_A1ZHW6 Cluster: NAD-dependent deacetylase; n=2; Microsc... 41 0.059
UniRef50_Q2U9Y7 Cluster: Sirtuin 4 and related class II sirtuins... 41 0.059
UniRef50_A2QWZ2 Cluster: Function: human SIRT5 belongs to the Si... 41 0.059
UniRef50_Q1EP52 Cluster: Transcriptional regulator Sir2 family p... 40 0.079
UniRef50_Q5KG84 Cluster: Hst4 protein, putative; n=2; Filobasidi... 40 0.079
UniRef50_Q2HG51 Cluster: Putative uncharacterized protein; n=2; ... 40 0.079
UniRef50_Q7WLE5 Cluster: NAD-dependent deacetylase; n=47; Bacter... 40 0.079
UniRef50_A7H7B6 Cluster: Silent information regulator protein Si... 40 0.10
UniRef50_A3WK56 Cluster: SIR2-like regulatory protein, NAD-depen... 40 0.10
UniRef50_A0DQW0 Cluster: Chromosome undetermined scaffold_6, who... 40 0.10
UniRef50_Q4P3S4 Cluster: Putative uncharacterized protein; n=1; ... 40 0.10
UniRef50_P53687 Cluster: NAD-dependent histone deacetylase HST3;... 40 0.10
UniRef50_UPI00015B48CB Cluster: PREDICTED: similar to 85 kda cal... 40 0.14
UniRef50_UPI000023E2DA Cluster: hypothetical protein FG00460.1; ... 40 0.14
UniRef50_Q4HK96 Cluster: Putative uncharacterized protein; n=1; ... 40 0.14
UniRef50_A1ZZG3 Cluster: NAD-dependent deacetylase; n=35; Bacter... 40 0.14
UniRef50_A0JXS0 Cluster: Silent information regulator protein Si... 40 0.14
UniRef50_Q23YS7 Cluster: Transcriptional regulator, Sir2 family ... 40 0.14
UniRef50_UPI0000DB7785 Cluster: PREDICTED: similar to CG6216-PA,... 39 0.18
UniRef50_A4A980 Cluster: NAD-dependent deacetylase; n=5; Gammapr... 39 0.18
UniRef50_A1ZMS1 Cluster: Silent information regulator protein Si... 39 0.18
UniRef50_Q75DM1 Cluster: ABL004Wp; n=1; Eremothecium gossypii|Re... 39 0.18
UniRef50_A2QUR5 Cluster: Remark: the H. sapiens SIRT4 belongs to... 39 0.18
UniRef50_P06700 Cluster: NAD-dependent histone deacetylase SIR2;... 39 0.18
UniRef50_UPI000050FCF4 Cluster: COG0846: NAD-dependent protein d... 39 0.24
UniRef50_Q893Y5 Cluster: Putative flagellar hook-length control ... 39 0.24
UniRef50_Q8A3H9 Cluster: NAD-dependent deacetylase; n=3; Bactero... 39 0.24
UniRef50_A7HID4 Cluster: Silent information regulator protein Si... 38 0.32
UniRef50_Q6CAJ8 Cluster: Similar to sp|P53687 Saccharomyces cere... 38 0.32
UniRef50_UPI0000DB6B83 Cluster: PREDICTED: similar to lava lamp ... 38 0.42
UniRef50_Q4QKL5 Cluster: NAD-dependent deacetylase sirtuin 5; n=... 38 0.42
UniRef50_A6XDL2 Cluster: Sirtuin 1; n=2; Schistosoma|Rep: Sirtui... 38 0.42
UniRef50_Q6MJJ2 Cluster: NAD-dependent deacetylase; n=5; Proteob... 38 0.42
UniRef50_A6FYM4 Cluster: Sir2 family protein; n=1; Plesiocystis ... 38 0.55
UniRef50_Q7R934 Cluster: Putative uncharacterized protein PY0703... 38 0.55
UniRef50_Q2KH01 Cluster: Putative uncharacterized protein; n=2; ... 38 0.55
UniRef50_Q8ZFR1 Cluster: NAD-dependent deacetylase; n=149; cellu... 38 0.55
UniRef50_A2ABY8 Cluster: Sirtuin 7 (Silent mating type informati... 37 0.73
UniRef50_Q54LF0 Cluster: Ankyrin repeat-containing protein; n=1;... 37 0.97
UniRef50_Q4P2A5 Cluster: Putative uncharacterized protein; n=1; ... 37 0.97
UniRef50_Q62HT8 Cluster: Transcriptional regulator, Sir2 family;... 36 1.3
UniRef50_Q5ZGC8 Cluster: Putative uncharacterized protein; n=1; ... 36 1.3
UniRef50_UPI00015B4688 Cluster: PREDICTED: similar to ENSANGP000... 36 1.7
UniRef50_UPI00005A356B Cluster: PREDICTED: similar to NAD-depend... 36 2.2
UniRef50_Q8IL21 Cluster: RNA helicase, putative; n=2; Plasmodium... 36 2.2
UniRef50_Q245U1 Cluster: Putative uncharacterized protein; n=1; ... 36 2.2
UniRef50_A6AY22 Cluster: Type III secretion chaperone, CesT fami... 35 3.0
UniRef50_A0M4I6 Cluster: Protein containing AAA ATPase domain; n... 35 3.0
UniRef50_Q55CX9 Cluster: Putative uncharacterized protein; n=1; ... 35 3.9
UniRef50_A2DKY5 Cluster: Transcriptional regulator, Sir2 family ... 35 3.9
UniRef50_A5DW75 Cluster: Putative uncharacterized protein; n=1; ... 35 3.9
UniRef50_P38747 Cluster: OTU domain-containing protein 2; n=3; S... 35 3.9
UniRef50_A6Q946 Cluster: Transcriptional regulator, Sir2 family;... 34 5.2
UniRef50_Q4R325 Cluster: Testis cDNA clone: QtsA-20073, similar ... 34 5.2
UniRef50_Q7R8P2 Cluster: Histone deacetylase family, putative; n... 34 5.2
UniRef50_Q59Y24 Cluster: Putative uncharacterized protein YNG1; ... 34 5.2
UniRef50_O25849 Cluster: NAD-dependent deacetylase; n=11; Bacter... 34 5.2
UniRef50_Q9FKC7 Cluster: Genomic DNA, chromosome 5, TAC clone:K2... 34 6.8
UniRef50_Q551S2 Cluster: Putative uncharacterized protein; n=2; ... 34 6.8
UniRef50_Q4XAH7 Cluster: Putative uncharacterized protein; n=1; ... 34 6.8
UniRef50_Q4U8V8 Cluster: Nucleoporin, putative; n=2; Theileria|R... 34 6.8
UniRef50_UPI00006CC00D Cluster: hypothetical protein TTHERM_0041... 33 9.0
UniRef50_Q7QSM5 Cluster: GLP_618_7785_10862; n=1; Giardia lambli... 33 9.0
UniRef50_Q4Z640 Cluster: Putative uncharacterized protein; n=4; ... 33 9.0
UniRef50_Q4Z3N0 Cluster: Putative uncharacterized protein; n=5; ... 33 9.0
>UniRef50_Q9VH08 Cluster: CG6284-PA; n=9; Eumetazoa|Rep: CG6284-PA -
Drosophila melanogaster (Fruit fly)
Length = 317
Score = 389 bits (958), Expect = e-107
Identities = 183/309 (59%), Positives = 232/309 (75%), Gaps = 4/309 (1%)
Query: 1 MSCNYAEGLSPYENKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAG 60
MSCNYA+GLS Y+NKGILG PE FDS++ + +KC LA+L+K S H+V+HTGAGISTSAG
Sbjct: 1 MSCNYADGLSAYDNKGILGAPESFDSDEVVAEKCQELAELIKKSGHVVLHTGAGISTSAG 60
Query: 61 IPDFRGPNGVWTLEKEGKKPTINVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHL 120
IPDFRGP GVWTLE++G+KP NVSF +A+PTKTHM +SQNIDGLHL
Sbjct: 61 IPDFRGPKGVWTLEEKGEKPDFNVSFDEARPTKTHMAIIALIESGYVQYVISQNIDGLHL 120
Query: 121 KSGVPRKFLAELHGNMFIDECNICKRQFVRSSPVETVGKKCSGVPC-AAHHVTGRPCR-G 178
KSG+ RK+L+ELHGN++I++C C+RQFV S VETVG+K C ++ GR CR G
Sbjct: 121 KSGLDRKYLSELHGNIYIEQCKKCRRQFVSPSAVETVGQKSLQRACKSSMDSKGRSCRSG 180
Query: 179 RLYDGVLDWEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVIC 238
LYD VLDWEH LPENDL M HS++ADL+I LGTTLQIVPSG+LPL+ +K GGK VIC
Sbjct: 181 ILYDNVLDWEHDLPENDLEMGVMHSTVADLNIALGTTLQIVPSGDLPLKNLKCGGKFVIC 240
Query: 239 NLQPTKHDNKADLLINYYVDDVLEKVMDILGIEIPSYNESENPMKFAETAIIDWSIDRKD 298
NLQPTKHD KA+L+I+ YVD VL KV +LG+EIP Y+E+ +P K ++ ++W+I +
Sbjct: 241 NLQPTKHDKKANLIISSYVDVVLSKVCKLLGVEIPEYSEASDPTK--QSKPMEWTIPTSN 298
Query: 299 VLALEKTFK 307
V + +K
Sbjct: 299 VNTFHRQYK 307
>UniRef50_Q8N6T7 Cluster: Mono-ADP-ribosyltransferase sirtuin-6;
n=22; Euteleostomi|Rep: Mono-ADP-ribosyltransferase
sirtuin-6 - Homo sapiens (Human)
Length = 355
Score = 314 bits (770), Expect = 3e-84
Identities = 153/277 (55%), Positives = 194/277 (70%), Gaps = 1/277 (0%)
Query: 1 MSCNYAEGLSPYENKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAG 60
MS NYA GLSPY +KG G+PE FD ++L +K LA+LV S +V HTGAGIST++G
Sbjct: 1 MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASG 60
Query: 61 IPDFRGPNGVWTLEKEGKKPTINVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHL 120
IPDFRGP+GVWT+E+ G P + +F A+PT+THM VSQN+DGLH+
Sbjct: 61 IPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHV 120
Query: 121 KSGVPRKFLAELHGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTG-RPCRGR 179
+SG PR LAELHGNMF++EC CK Q+VR + V T+G K +G C G R CRG
Sbjct: 121 RSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGE 180
Query: 180 LYDGVLDWEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICN 239
L D +LDWE SLP+ DL +A+ S ADLSI LGT+LQI PSGNLPL T + GG+LVI N
Sbjct: 181 LRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVN 240
Query: 240 LQPTKHDNKADLLINYYVDDVLEKVMDILGIEIPSYN 276
LQPTKHD ADL I+ YVD+V+ ++M LG+EIP+++
Sbjct: 241 LQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWD 277
>UniRef50_Q9FE17 Cluster: Sir2-like protein; n=9; Magnoliophyta|Rep:
Sir2-like protein - Arabidopsis thaliana (Mouse-ear
cress)
Length = 473
Score = 256 bits (626), Expect = 9e-67
Identities = 131/276 (47%), Positives = 178/276 (64%), Gaps = 6/276 (2%)
Query: 1 MSCNYAEGLSPYENKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAG 60
MS YAE LS E+ G +G+ E FD + L K LA+L++ SKH+VV TGAGISTS G
Sbjct: 1 MSLGYAEKLSFIEDVGQVGMAEFFDPSHLLQCKIEELAKLIQKSKHLVVFTGAGISTSCG 60
Query: 61 IPDFRGPNGVWTLEKEGKK-PTINVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLH 119
IPDFRGP G+WTL++EGK P ++ F A P+ THM +SQN+DGLH
Sbjct: 61 IPDFRGPKGIWTLQREGKDLPKASLPFHRAMPSMTHMALVELERAGILKFVISQNVDGLH 120
Query: 120 LKSGVPRKFLAELHGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGR 179
L+SG+PR+ L+ELHG+ F++ C C +++R VET+G K + C+ C +
Sbjct: 121 LRSGIPREKLSELHGDSFMEMCPSCGAEYLRDFEVETIGLKETSRKCSVEK-----CGAK 175
Query: 180 LYDGVLDWEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICN 239
L D VLDWE +LP ++ AE H ADL +CLGT+LQI P+ NLPL+ +K GGK+VI N
Sbjct: 176 LKDTVLDWEDALPPKEIDPAEKHCKKADLVLCLGTSLQITPACNLPLKCLKGGGKIVIVN 235
Query: 240 LQPTKHDNKADLLINYYVDDVLEKVMDILGIEIPSY 275
LQ T D KA+++I+ VD V+ VM+ L ++IP Y
Sbjct: 236 LQKTPKDKKANVVIHGLVDKVVAGVMESLNMKIPPY 271
>UniRef50_Q8N6T7-2 Cluster: Isoform 2 of Q8N6T7 ; n=5;
Catarrhini|Rep: Isoform 2 of Q8N6T7 - Homo sapiens
(Human)
Length = 328
Score = 255 bits (625), Expect = 1e-66
Identities = 138/276 (50%), Positives = 176/276 (63%), Gaps = 26/276 (9%)
Query: 1 MSCNYAEGLSPYENKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAG 60
MS NYA GLSPY +KG G+PE FD ++L +K LA+LV S +V HTGAGIST++G
Sbjct: 1 MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASG 60
Query: 61 IPDFRGPNGVWTLEKEGKKPTINVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHL 120
IPDFRGP+GVWT+E+ G P + +F A+PT+THM VSQN+DGLH+
Sbjct: 61 IPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHV 120
Query: 121 KSGVPRKFLAELHGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRL 180
+SG PR LAELHGNMF++EC CK Q+VR + V T+G K TGR C
Sbjct: 121 RSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKA----------TGRLCTVAK 170
Query: 181 YDGVLDWEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNL 240
G+ + ADLSI LGT+LQI PSGNLPL T + GG+LVI NL
Sbjct: 171 ARGLRACRN----------------ADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNL 214
Query: 241 QPTKHDNKADLLINYYVDDVLEKVMDILGIEIPSYN 276
QPTKHD ADL I+ YVD+V+ ++M LG+EIP+++
Sbjct: 215 QPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWD 250
>UniRef50_UPI0000E49846 Cluster: PREDICTED: similar to Sirtuin
(silent mating type information regulation 2 homolog) 6
(S. cerevisiae); n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to Sirtuin (silent mating type
information regulation 2 homolog) 6 (S. cerevisiae) -
Strongylocentrotus purpuratus
Length = 521
Score = 252 bits (616), Expect = 1e-65
Identities = 135/283 (47%), Positives = 179/283 (63%), Gaps = 5/283 (1%)
Query: 65 RGPNGVWTLEKEGKKPTINVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGV 124
RGP GVWTLEK+GKKP NV+F A+PT THM +SQNIDGLHL+SG
Sbjct: 11 RGPKGVWTLEKQGKKPEANVTFDTAKPTATHMALVELERRGKLQYLISQNIDGLHLRSGF 70
Query: 125 PRKFLAELHGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGV 184
P+ LAELHGNMF+++C+ C+RQ +R+ PV T+G K +G C+ G CRG+L+D +
Sbjct: 71 PKDRLAELHGNMFVEQCHRCRRQTIRAMPVPTLGLKPTGNRCSDKPGRGT-CRGKLHDTI 129
Query: 185 LDWEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTK 244
LDWE +LPE DL AE H +DLSICLGT+LQI+PSG LP T K GG LVI NLQPTK
Sbjct: 130 LDWEDALPETDLTQAEEHLRKSDLSICLGTSLQIIPSGTLPKLTKKNGGSLVIVNLQPTK 189
Query: 245 HDNKADLLINYYVDDVLEKVMDILGIEIPSYNESENPMKFAETAIIDWSIDRKDVLALEK 304
D +AD+ IN YVD+V+ ++M+ LG IP Y ++ + D V +K
Sbjct: 190 LDKQADMKINCYVDEVMTQLMEQLGYPIPEYTGPSLVLESQQGLSTKNIKDTMHVGDSQK 249
Query: 305 TFK--SKCKGVKKKRILIKTKRFTSNANDIEKSKMIKLEVKEE 345
K S+C ++K + +K + + ND +K + IK EVKE+
Sbjct: 250 NCKVDSECVDDRRK-VAVKDEVKEESMNDGQKVE-IKDEVKEK 290
>UniRef50_A5AF92 Cluster: Putative uncharacterized protein; n=1;
Vitis vinifera|Rep: Putative uncharacterized protein -
Vitis vinifera (Grape)
Length = 343
Score = 200 bits (488), Expect = 5e-50
Identities = 102/216 (47%), Positives = 141/216 (65%), Gaps = 9/216 (4%)
Query: 30 LNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKK-PTINVSFAD 88
+++K LA +++ SKH+VV TGAGISTS GIPDFRGP G+WTL++EGK P ++ F
Sbjct: 61 MHKKIERLAVMLRKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQREGKALPQASLPFHR 120
Query: 89 AQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNICKRQF 148
A P+ THM +SQNIDGLHL+SG+PR LAELHGN F++ C+ C ++
Sbjct: 121 AMPSMTHMALVELEKAGILKFVISQNIDGLHLRSGIPRDKLAELHGNSFMEICSSCGIEY 180
Query: 149 ---VRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAEWHSSI 205
+ VET+G K + C+ C +L D VLDWE +LP ++ AE H +
Sbjct: 181 DFNLYLHLVETIGLKETSRRCS-----NVDCGAKLRDTVLDWEDALPPKEMNPAEKHCRM 235
Query: 206 ADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQ 241
AD+ +CLGT+LQI P+ NLPL++++ GGK+VI NLQ
Sbjct: 236 ADVVLCLGTSLQITPACNLPLKSLRGGGKIVIVNLQ 271
>UniRef50_Q7SB01 Cluster: Putative uncharacterized protein
NCU07624.1; n=1; Neurospora crassa|Rep: Putative
uncharacterized protein NCU07624.1 - Neurospora crassa
Length = 437
Score = 165 bits (401), Expect = 2e-39
Identities = 102/275 (37%), Positives = 145/275 (52%), Gaps = 25/275 (9%)
Query: 22 EKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPT 81
E F++ + +++K +LA L++ SKH VV TGAG+STSAGIPDFRGP GVWTL +G++ T
Sbjct: 12 EMFEAPEVIDRKAKVLADLIRKSKHFVVFTGAGVSTSAGIPDFRGPEGVWTLMAQGRQAT 71
Query: 82 -INVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDE 140
+V A PTKTHM +SQN DGLH +SG+ ++ELHGN I+
Sbjct: 72 KKSVDVLQAIPTKTHMALVELQERGILKGLISQNCDGLHRRSGIRADMISELHGNTNIEH 131
Query: 141 CNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPC----RGRLYDGVLDWEHSLPENDL 196
C C ++F+R+ + P H TGR C L+D ++ + LP
Sbjct: 132 CKNCGKEFLRA---DFYAVAPDNRPLHDHR-TGRKCPICLTQPLHDTIIHFSEDLPLGPW 187
Query: 197 LMAEWHSSIADLSICLGTTLQIVPSGNLP-------------LETIKYGGKLVICNLQPT 243
AE H ADL + LG++L + P+ LP +T + LVICNLQ T
Sbjct: 188 SRAEAHCEKADLCLVLGSSLTVTPANELPQLVGERAAAQRKKQQTQQPDTDLVICNLQDT 247
Query: 244 KHD---NKADLLINYYVDDVLEKVMDILGIEIPSY 275
D D I DD++E+VM L + +P++
Sbjct: 248 DLDYLCPSPDHRIYARADDLMERVMHYLSLPVPNF 282
>UniRef50_Q22KA8 Cluster: Transcriptional regulator, Sir2 family
protein; n=3; Tetrahymena thermophila SB210|Rep:
Transcriptional regulator, Sir2 family protein -
Tetrahymena thermophila SB210
Length = 386
Score = 165 bits (400), Expect = 2e-39
Identities = 104/270 (38%), Positives = 149/270 (55%), Gaps = 23/270 (8%)
Query: 22 EKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFR-GPN-------GVWT- 72
E FDS + L K LA ++K S H V TGAGISTSAGI DFR G N G+W
Sbjct: 13 EYFDSPELLEAKVTQLADMIKQSNHFVCFTGAGISTSAGIADFRSGVNTVLKTGPGLWEK 72
Query: 73 -LEKEGKKPTIN-VSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLA 130
+K G +P + V + A PTK+HM +SQNIDGLH +SG L+
Sbjct: 73 MAQKVGNQPKKHKVIMSRAVPTKSHMALVKLNQEGILKYLISQNIDGLHRRSGFNPNSLS 132
Query: 131 ELHGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGR-----PCRGRLYDGVL 185
ELHGN +++C C + ++R V +K V H+TGR C G L D ++
Sbjct: 133 ELHGNTNLEKCLKCGKSYMRDYRV----RKALDVH---DHLTGRICDNQKCGGELVDTIV 185
Query: 186 DWEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKH 245
++ +LP+ D+ ++S ADL + LG++L++ P+ ++PL T + G KLV+ NLQ T
Sbjct: 186 NFGENLPKKDMEQGFFNSKQADLHLVLGSSLRVTPAADMPLATAQNGNKLVVVNLQKTPL 245
Query: 246 DNKADLLINYYVDDVLEKVMDILGIEIPSY 275
D+ L I +DDV+ +M LG+EIP +
Sbjct: 246 DSLCALRIYALIDDVMVLLMKKLGLEIPEF 275
>UniRef50_Q95Q89 Cluster: Yeast sir related protein 2.4; n=2;
Caenorhabditis|Rep: Yeast sir related protein 2.4 -
Caenorhabditis elegans
Length = 299
Score = 161 bits (391), Expect = 3e-38
Identities = 87/236 (36%), Positives = 126/236 (53%), Gaps = 5/236 (2%)
Query: 39 QLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSFADAQPTKTHMXX 98
Q + K I V GAG+ST + +PDFRG GVWTL+ EGK V F A+P +H
Sbjct: 50 QAKQTGKPIFVLIGAGVSTGSKLPDFRGKQGVWTLQAEGKHAE-GVDFQVARPGVSHKSI 108
Query: 99 XXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNICKRQFVRSSPVETVG 158
++QN+DGL K G+P + L E+HGN+F++ C C ++VR V +VG
Sbjct: 109 LALHKAGYIKTIITQNVDGLDRKVGIPVEDLIEVHGNLFLEVCQSCFSEYVREEIVMSVG 168
Query: 159 KKCSGVPCAAHHVTGRPCRGRLYDGVLDW--EHSLPENDLLMAEWHSSIADLSICLGTTL 216
+G C + TGR CRG+L D LDW E SL D + W + +C+GT+L
Sbjct: 169 LCPTGRNCEGNKRTGRSCRGKLRDATLDWDTEISLNHLDRIRKAWKQT--SHLLCIGTSL 226
Query: 217 QIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYYVDDVLEKVMDILGIEI 272
+I+P G+LPL+ G K N Q T H+ + I+ V +L + + LG+ +
Sbjct: 227 EIIPMGSLPLDAKSKGIKTTTINYQETAHEKIVETAIHADVKLILYSLCNALGVNV 282
>UniRef50_UPI0000D573CE Cluster: PREDICTED: similar to CG11305-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG11305-PA - Tribolium castaneum
Length = 627
Score = 160 bits (389), Expect = 5e-38
Identities = 116/348 (33%), Positives = 178/348 (51%), Gaps = 21/348 (6%)
Query: 22 EKFDSNDK-LNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKP 80
E+F+ + L +KC++LAQ + ++H+VV+TGAGIST+A IPD+RGPNG+WT ++GK
Sbjct: 96 EEFEEPPEVLKEKCLILAQAIAQAQHLVVYTGAGISTAAKIPDYRGPNGIWTRLQQGKDI 155
Query: 81 TINVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDE 140
+ + A+PT THM VSQN DGLHL+SG+PR L+ELHGNM+I+
Sbjct: 156 GAH-DLSMAEPTYTHMALSELYRNKILKYVVSQNCDGLHLRSGLPRTALSELHGNMYIEV 214
Query: 141 CNICK--RQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYD----GVLDWEHSLPEN 194
C CK +++ R V + S +V P + G L W P N
Sbjct: 215 CKTCKPHKEYWRLFDVTENTARYSHKTSRRCYVCNEPLVDTIVHFGERGSLQW----PLN 270
Query: 195 DLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGK---LVICNLQPTKHDNKADL 251
A ++ A +CLG++L+++ K K L I NLQ T D+ A++
Sbjct: 271 -WAGACKNAEKATTIVCLGSSLKVLKKYPWLWRMDKPAKKRPNLYIVNLQWTPKDDVANV 329
Query: 252 LINYYVDDVLEKVMDILGIEIPSYNESENPMKFAETAIIDWSIDRKDVLALEKTFKSKCK 311
I+ D V+E VM++L I++P Y++S++P+ T + D + L+ + K
Sbjct: 330 KIHGKCDQVMEAVMNLLDIKVPPYDKSKDPIFAHGTLLCDAELHTTSQPLLKLEDEKKEF 389
Query: 312 GVKKKRILIKTKRFTSNANDIEKSKMIKLEVKEENETKDWPLKPSDQE 359
V+K I T+ ND+ + IK E + + D PS E
Sbjct: 390 PVQKNGI---KDCSTNRDNDLSSTNSIKSEFCDTSSNSD--TSPSHSE 432
>UniRef50_Q9NRC8 Cluster: NAD-dependent deacetylase sirtuin-7; n=24;
Eumetazoa|Rep: NAD-dependent deacetylase sirtuin-7 -
Homo sapiens (Human)
Length = 400
Score = 155 bits (377), Expect = 1e-36
Identities = 103/272 (37%), Positives = 154/272 (56%), Gaps = 19/272 (6%)
Query: 22 EKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPT 81
E D ++L K LA V+++K++VV+TGAGIST+A IPD+RGPNGVWTL ++G+ +
Sbjct: 77 EVCDDPEELRGKVRELASAVRNAKYLVVYTGAGISTAASIPDYRGPNGVWTLLQKGRSVS 136
Query: 82 INVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDEC 141
++A+PT THM VSQN DGLHL+SG+PR ++ELHGNM+I+ C
Sbjct: 137 A-ADLSEAEPTLTHMSITRLHEQKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVC 195
Query: 142 NIC--KRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCR---GRLYDGVLDW-EHSLPEND 195
C R++VR V V ++ + H TGR C +L D ++ + E
Sbjct: 196 TSCVPNREYVR---VFDVTERTA----LHRHQTGRTCHKCGTQLRDTIVHFGERGTLGQP 248
Query: 196 L--LMAEWHSSIADLSICLGTTLQIV---PSGNLPLETIKYGGKLVICNLQPTKHDNKAD 250
L A +S AD +CLG++L+++ P + KL I NLQ T D+ A
Sbjct: 249 LNWEAATEAASRADTILCLGSSLKVLKKYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAA 308
Query: 251 LLINYYVDDVLEKVMDILGIEIPSYNESENPM 282
L ++ DDV+ +M LG+EIP+Y+ ++P+
Sbjct: 309 LKLHGKCDDVMRLLMAELGLEIPAYSRWQDPI 340
>UniRef50_Q175I4 Cluster: Chromatin regulatory protein sir2; n=3;
Coelomata|Rep: Chromatin regulatory protein sir2 - Aedes
aegypti (Yellowfever mosquito)
Length = 720
Score = 154 bits (374), Expect = 3e-36
Identities = 119/356 (33%), Positives = 181/356 (50%), Gaps = 30/356 (8%)
Query: 22 EKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKK-P 80
EK D +++ K + LAQ + S H++V+TGAGISTSA IPD+RG G+WTL +GK
Sbjct: 58 EKEDEPEEIETKALRLAQAIARSNHLMVYTGAGISTSAKIPDYRGSQGIWTLLAQGKDIG 117
Query: 81 TINVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDE 140
++S AD PT THM VSQN DGLHL+SG+PR L+E+HGNM+++
Sbjct: 118 EYDLSLAD--PTYTHMALSELHRRGILKHVVSQNCDGLHLRSGLPRFCLSEVHGNMYVEV 175
Query: 141 CNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCR--GR-LYDGVLDW----EHSLPE 193
C CK +T + + H T R CR G+ L D ++ + + P
Sbjct: 176 CKNCKPNVEYWRLFDTTQRTST-----HKHKTNRRCRKCGKPLIDTIVHFGERGQLKWPL 230
Query: 194 NDLLMAEWHSSIADLSICLGTTLQIVPSGNLPL---ETIKYGGKLVICNLQPTKHDNKAD 250
N A H+ D +CLG++L+++ N + IK KL I NLQ T D +
Sbjct: 231 N-WAGATPHTEKTDAILCLGSSLKVLRKYNWLWAIDKPIKKRPKLFIVNLQWTPKDKVSA 289
Query: 251 LLINYYVDDVLEKVMDILGIEIPSYNESENPMKFAETAIIDWSIDRKDVLALEKTFKSKC 310
L IN D+V+ VM L I++P YN ++P+ FA ++ + + A + K
Sbjct: 290 LKINGKCDEVMRLVMKHLNIDVPEYNRIKDPI-FAHATLL---LPEEQHTASQPMLK--- 342
Query: 311 KGVKKKRILIKTKRFTSNANDIEKSKMI-KLEVKEENETKDWPLKPSDQEFIIDQK 365
K +K + I + +SN +++ + +EVK+E + PL S + Q+
Sbjct: 343 KAIKDE---ICGESSSSNGFQVKQEPLADNVEVKKEPTLQQIPLLLSPPSLLTPQQ 395
>UniRef50_UPI00015B56BB Cluster: PREDICTED: similar to
ENSANGP00000025716; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000025716 - Nasonia
vitripennis
Length = 581
Score = 153 bits (370), Expect = 9e-36
Identities = 98/271 (36%), Positives = 145/271 (53%), Gaps = 23/271 (8%)
Query: 25 DSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINV 84
D+ + L +KC+ LA + + + V+TGAGIST+A IPD+RG NGVWT ++GK N
Sbjct: 91 DAPEILEEKCIRLAAAISRATSLAVYTGAGISTAASIPDYRGTNGVWTRLQQGKDIG-NH 149
Query: 85 SFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNIC 144
+ A+PT THM VSQN DGLHL+SG+PR L+E+HGNM+++ C C
Sbjct: 150 DLSQAEPTITHMALYALYKARMLKHIVSQNCDGLHLRSGIPRPLLSEVHGNMYVEVCRTC 209
Query: 145 K--RQFVRSSPVETVGKKCSGVPCAAHHVTGR---PCRGRLYDGVLDWEHSLPENDLLMA 199
K R++ R V + + H TGR C L D ++ + N L
Sbjct: 210 KPSREYWRLFDVTEKTARYA-------HSTGRTCHKCNSPLQDSIVHFGER--GNLLWPI 260
Query: 200 EWHSSI-----ADLSICLGTTLQIVPSGNLPLETIKYGGK---LVICNLQPTKHDNKADL 251
W+ + AD+ +CLG++L+++ + + K L I NLQ T D+ A L
Sbjct: 261 NWNGASRAAKQADVILCLGSSLKVLKKYPWLWQMDRPVAKRPQLYIVNLQWTPKDDNAVL 320
Query: 252 LINYYVDDVLEKVMDILGIEIPSYNESENPM 282
IN D V++ VM LGI+IP Y +++P+
Sbjct: 321 KINGKCDQVMKIVMSHLGIDIPCYQRAKDPI 351
>UniRef50_A7AWG1 Cluster: Transcriptional regulator, Sir2 family
domain containing protein; n=2; Babesia bovis|Rep:
Transcriptional regulator, Sir2 family domain containing
protein - Babesia bovis
Length = 656
Score = 148 bits (358), Expect = 3e-34
Identities = 98/300 (32%), Positives = 152/300 (50%), Gaps = 32/300 (10%)
Query: 5 YAEGLSPYENKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDF 64
YA L P +NKG G + FD+ +++K +L+ +K++V+H+GAG+ST+AGIPDF
Sbjct: 8 YANQLRPNDNKGPCGGVQLFDNPADISKKFKQTVELLTRAKNVVLHSGAGMSTAAGIPDF 67
Query: 65 RGPNGVWTL-------EKEGK--------KPTIN------------VSFADAQPTKTHMX 97
RGP+GVWT+ K+ K K T N V F+ A P++ H+
Sbjct: 68 RGPSGVWTVMSHKRVGNKKRKMTDGDCTVKDTSNTCVEFGTTKLEPVEFSHALPSEAHLA 127
Query: 98 XXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNICKRQFVRSSPVETV 157
++QNIDGLH SG+ ELHGN+FI+ C C R+++R T+
Sbjct: 128 TLALLRAGYIRTVITQNIDGLHAISGMKHSECIELHGNVFIERCIFCARRYLRPYVAPTI 187
Query: 158 GKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAEWHSSIADLSICLGTTLQ 217
K +G C + P G L D VLDW ++ A H+ AD + LG++L
Sbjct: 188 SFKPTGSHCG---LCNFPPYGILTDVVLDWFDRYEDHFEKRAISHAEEADFHLTLGSSLH 244
Query: 218 IVPSGNLPLET--IKYGGKLVICNLQPTKHDNKADLLINYYVDDVLEKVMDILGIEIPSY 275
+ P+ K LVI N Q T+ D +AD++++ V+ + +K++ IE P++
Sbjct: 245 VEPACCYASSEHFRKENAPLVIVNYQKTRLDPEADVVLHCDVNQICKKLLKTFNIEAPTF 304
>UniRef50_Q9VAQ1 Cluster: CG11305-PA; n=8; Coelomata|Rep: CG11305-PA
- Drosophila melanogaster (Fruit fly)
Length = 771
Score = 144 bits (350), Expect = 2e-33
Identities = 90/278 (32%), Positives = 146/278 (52%), Gaps = 12/278 (4%)
Query: 20 VPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKK 79
V E+ D+ + K LA ++ +KH+V +TGAGIST+A IPD+RG G+WTL ++G+
Sbjct: 99 VVEREDAPHVIEAKVEQLANIISQAKHLVCYTGAGISTAALIPDYRGSQGIWTLLQKGQD 158
Query: 80 PTINVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFID 139
+ + A PT THM VSQN DGLHL+SG+PR L+E+HGNM+++
Sbjct: 159 IGEH-DLSSANPTYTHMALYELHRRRLLHHVVSQNCDGLHLRSGLPRNSLSEIHGNMYVE 217
Query: 140 ECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEH----SLPEND 195
C C+ V +T + + C H C LYD ++ + P N
Sbjct: 218 VCKNCRPNSVYWRQFDTT--EMTARYCHKTHRLCHRCSEPLYDTIVHFGERGNVKWPLN- 274
Query: 196 LLMAEWHSSIADLSICLGTTLQIVPSGNLPLE---TIKYGGKLVICNLQPTKHDNKADLL 252
A ++ AD+ +CLG++L+++ + + K+ + NLQ T D A +
Sbjct: 275 WAGATANAQRADVILCLGSSLKVLKKYTWLWQMDRPARQRAKICVVNLQWTPKDAIASIK 334
Query: 253 INYYVDDVLEKVMDILGIEIPSYNESENPMKFAETAII 290
IN D V+ ++M +L I +P Y + ++P+ FA +++
Sbjct: 335 INGKCDQVMAQLMHLLHIPVPVYTKEKDPI-FAHASLL 371
>UniRef50_UPI00006CB0CC Cluster: transcriptional regulator, Sir2
family protein; n=1; Tetrahymena thermophila SB210|Rep:
transcriptional regulator, Sir2 family protein -
Tetrahymena thermophila SB210
Length = 442
Score = 119 bits (287), Expect = 1e-25
Identities = 90/278 (32%), Positives = 141/278 (50%), Gaps = 27/278 (9%)
Query: 14 NKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFR-GPN---- 68
N + E DS ++++ K L +L++ SK+ V+ TGAG+ST++GIPD+R G N
Sbjct: 38 NPRLKDTQEHQDSPEQIDTKVNQLIELLQKSKNAVILTGAGVSTASGIPDYRSGANTILK 97
Query: 69 ---GVWTLEKEGKK-------PTINVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGL 118
G W LE+ KK P I ++ +A P+ THM ++QN+D L
Sbjct: 98 TGPGKWELEENKKKFLEEKGKPQIILAI-NAFPSPTHMAISKLYKENLIKSVITQNVDNL 156
Query: 119 HLKSGVPRKFLAELHGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCR- 177
H +SG+PRK + ELHGN+ + C C R K G P H TGR C+
Sbjct: 157 HHQSGIPRKDIHELHGNIISERCEKCNYVHYRDFYTRLKHLKW-GDP----HNTGRICQK 211
Query: 178 ----GRLYDGVLDWEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGG 233
G+L+D ++ + S+ +N A+ ADL I +GT+L + + L + + G
Sbjct: 212 NGCDGQLHDTLVFFGESVLQNIKQSAQEQIESADLCIVVGTSLTVQSAARLVWISQQRGI 271
Query: 234 KLVICNLQPTKHDNKADLLINYYVDDVLEKVMDILGIE 271
+VI NLQ T +D+KA L IN + + + ++ L +
Sbjct: 272 PIVIINLQKTSYDSKA-LKINGLCEPIFDLILKKLNFQ 308
>UniRef50_Q2LSF2 Cluster: Sir2 family of NAD+-dependent deacetylase;
n=2; Syntrophus aciditrophicus SB|Rep: Sir2 family of
NAD+-dependent deacetylase - Syntrophus aciditrophicus
(strain SB)
Length = 271
Score = 118 bits (283), Expect = 3e-25
Identities = 76/260 (29%), Positives = 127/260 (48%), Gaps = 25/260 (9%)
Query: 26 SNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW-------------- 71
S+ + +K +A ++ + +VV TGAG+ST +GIPDFR P G+W
Sbjct: 7 SDREFMEKIDAVADMIWMAGRVVVFTGAGVSTESGIPDFRSPGGLWDRFDPDDFTIGKFL 66
Query: 72 ----TLEKEGKKPTINVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRK 127
T K+ + + A+AQP + H+ ++QNID LH K+G +
Sbjct: 67 RSAQTRRKQWRILIAGGALAEAQPNRAHLAVAELEKIGKLNCVITQNIDNLHQKAGNAPE 126
Query: 128 FLAELHGNMFIDECNIC-KRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLD 186
+ ELHGNM +C C R V ET ++ G P A C+G + V+
Sbjct: 127 KVYELHGNMRWLKCLSCGDRVSVPEMFRETALQEMDGFPFCAK------CQGLMKPDVIF 180
Query: 187 WEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHD 246
+ +LPE L A W + DL + +G++L + P+ +P+ G +LVI N T +D
Sbjct: 181 FGEALPEKTLRDATWQARNCDLLLVIGSSLVVYPAAYMPMYAKDAGARLVIINRDETPYD 240
Query: 247 NKADLLINYYVDDVLEKVMD 266
++AD+L+ +++ +++D
Sbjct: 241 SEADVLLQGSAGEIMSRILD 260
>UniRef50_Q9WYW0 Cluster: NAD-dependent deacetylase; n=4;
Thermotoga|Rep: NAD-dependent deacetylase - Thermotoga
maritima
Length = 246
Score = 105 bits (252), Expect = 2e-21
Identities = 85/249 (34%), Positives = 121/249 (48%), Gaps = 30/249 (12%)
Query: 40 LVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEG--------KKPTINVSFA---- 87
L+ +S+ V TGAGIST +GIPDFRGPNG++ + P FA
Sbjct: 9 LLNESRLTVTLTGAGISTPSGIPDFRGPNGIYKKYSQNVFDIDFFYSHPEEFYRFAKEGI 68
Query: 88 ----DAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNI 143
A+P H+ ++QNID LH ++G K + ELHGN+ C
Sbjct: 69 FPMLQAKPNLAHVLLAKLEEKGLIEAVITQNIDRLHQRAG--SKKVIELHGNVEEYYCVR 126
Query: 144 CKRQFVRSSPVETVGKKC--SGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAEW 201
C++++ VE V KK S VP C + ++ + +LP++ L A
Sbjct: 127 CEKKYT----VEDVIKKLESSDVPLCDD------CNSLIRPNIVFFGENLPQDALREAIG 176
Query: 202 HSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYYVDDVL 261
SS A L I LG++L + P+ LPL T++ GGKLVI NL T D+ A L N V +
Sbjct: 177 LSSRASLMIVLGSSLVVYPAAELPLITVRSGGKLVIVNLGETPFDDIATLKYNMDVVEFA 236
Query: 262 EKVMDILGI 270
+VM+ GI
Sbjct: 237 RRVMEEGGI 245
>UniRef50_Q89LY4 Cluster: NAD-dependent deacetylase 1; n=12;
Proteobacteria|Rep: NAD-dependent deacetylase 1 -
Bradyrhizobium japonicum
Length = 254
Score = 104 bits (249), Expect = 4e-21
Identities = 69/242 (28%), Positives = 113/242 (46%), Gaps = 25/242 (10%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEK----EG-------------KK 79
L ++ ++K IV TGAGIST GIPDFR P G+WT + +G ++
Sbjct: 15 LGDMIAEAKTIVPFTGAGISTECGIPDFRSPGGIWTRNRPIPFDGFVASQEARDESWRRR 74
Query: 80 PTINVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFID 139
+ +FA A+P + H ++QNID LH SG + + ELHGN
Sbjct: 75 FAMEETFAAARPGRGHRALASLYRAGKVPAVITQNIDNLHQASGFAHEHVIELHGNTTYA 134
Query: 140 ECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMA 199
C C + + ++ V ++ V P + + + +PE ++ A
Sbjct: 135 RCVGCGQTY----QLDWVKRRFDQDGAPNCTVCDEPVK----TATISFGQMMPEEEMQRA 186
Query: 200 EWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYYVDD 259
S DL I +G++L + P+ P+ + G +LVI N +PT+ D+ ADL+I + + +
Sbjct: 187 TALSRACDLFIAIGSSLVVWPAAGFPMMAKRAGARLVIINREPTEQDDIADLVIRHDIGE 246
Query: 260 VL 261
L
Sbjct: 247 TL 248
>UniRef50_Q974M6 Cluster: NAD-dependent deacetylase; n=8;
Thermoprotei|Rep: NAD-dependent deacetylase - Sulfolobus
tokodaii
Length = 250
Score = 102 bits (245), Expect = 1e-20
Identities = 79/252 (31%), Positives = 121/252 (48%), Gaps = 28/252 (11%)
Query: 33 KCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW--------TLEKEGKKPTINV 84
+C + L+ S + + TGAGIST++GIPDFRGPNG+W T+E K P
Sbjct: 2 ECDKVGDLLLTSTYAIAFTGAGISTASGIPDFRGPNGLWKKYSPELATIEYFKKDPKGFW 61
Query: 85 SFA--------DAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNM 136
F A P + H ++QNIDGLH +G + + ELHGNM
Sbjct: 62 EFYRLRMRGLFTALPNRAHYALAELEKMGLIRAIITQNIDGLHQLAG--SRNVIELHGNM 119
Query: 137 FIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDL 196
C C + + + ++ + K+ C V RP D VL E P ++
Sbjct: 120 RKCYCVNCLKTYDSDTVLDKIDKEGLPPKCECGGVI-RP------DVVLFGE---PVYNI 169
Query: 197 LMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYY 256
A + ADL + +G++L + P+ +PL + GGKL+I N + T DN AD+++
Sbjct: 170 SSALEIAREADLVLAIGSSLTVYPANMIPLTVKEMGGKLIILNAEETPLDNIADIVVRER 229
Query: 257 VDDVLEKVMDIL 268
V++ L V+D +
Sbjct: 230 VEEFLPCVVDYI 241
>UniRef50_A0NQ49 Cluster: Silent information regulator protein Sir2;
n=1; Stappia aggregata IAM 12614|Rep: Silent information
regulator protein Sir2 - Stappia aggregata IAM 12614
Length = 260
Score = 97.9 bits (233), Expect = 4e-19
Identities = 69/237 (29%), Positives = 103/237 (43%), Gaps = 40/237 (16%)
Query: 45 KHIVVHTGAGISTSAGIPDFRGPNGVWT------------------------LEKEGKKP 80
+ IV TGAGIST +GIPDFR P G+W+ LE ++
Sbjct: 23 RQIVALTGAGISTESGIPDFRSPGGIWSKRQPVQYQDFVDDEDSRLEDWDRRLEDWDRRS 82
Query: 81 TINVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDE 140
+ F A+P H ++QN+DGLH ++G P L E+HGN
Sbjct: 83 EMMDYFCKAEPNAAHFALTTLARSGKLVCLITQNVDGLHQRAGFPDDLLVEIHGNSTFAS 142
Query: 141 CNIC--KRQFVRSSPVETVGK--KCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDL 196
C C + + P G+ +CS C G L V+ + +PE +L
Sbjct: 143 CLSCGARAELEAQKPAVDAGESPRCS------------QCDGLLKAAVISFGQQMPEREL 190
Query: 197 LMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLI 253
A +S DL + LG++L + P+ LP ++ G +LVI N Q T D+ A ++
Sbjct: 191 QRAAEAASACDLFLVLGSSLVVHPAAQLPAVAVQSGAELVILNGQETPLDSYASTIV 247
>UniRef50_Q4UH74 Cluster: Sir2-like histone deacetylase, putative;
n=2; Theileria|Rep: Sir2-like histone deacetylase,
putative - Theileria annulata
Length = 928
Score = 97.1 bits (231), Expect = 6e-19
Identities = 65/251 (25%), Positives = 119/251 (47%), Gaps = 10/251 (3%)
Query: 84 VSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNI 143
V F A P+++H+ ++QN+DGLH SG+P L+ELHGN+F+ C
Sbjct: 182 VEFILALPSESHLCLLELLRRKKIRYIITQNVDGLHAVSGIPFDKLSELHGNVFVQRCLF 241
Query: 144 CKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAEWHS 203
C +++ R+ T+ K +G C + P L D VLDW + ++ S
Sbjct: 242 CHKRYQRNYVSPTISFKPTGDLCG---LCTFPPLNVLTDVVLDWFDCYEQYYEETSKLKS 298
Query: 204 SIADLSICLGTTLQIVPSGNLPLETI--KYGGKLVICNLQPTKHDNKADLLINYYVDDVL 261
+DL + +G++L I P+ + KY L+I N Q TK D + DL+I+ ++ +
Sbjct: 299 ESSDLHVVMGSSLHIEPACHYASNDYHRKYDSPLIIINYQSTKLDPECDLIIHEDINKIC 358
Query: 262 EKVMDILGIEIPSYNESEN--PMKFAETAIIDWSIDRKDVLALEKTFKSKCKGVKKKRIL 319
++ +++P++ + + +K+ TA + + +++ L KS C +K L
Sbjct: 359 TNLLKKFNLKVPTFFKKSHLFILKYNHTANVTTKTNEQNI-RLVVIMKSSC--IKSVEFL 415
Query: 320 IKTKRFTSNAN 330
+ + N
Sbjct: 416 SDSAEYRPKCN 426
Score = 83.8 bits (198), Expect = 6e-15
Identities = 35/70 (50%), Positives = 50/70 (71%)
Query: 4 NYAEGLSPYENKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPD 63
NYA L NKG LG+ E FD+N ++ +K LL + + S + ++HTGAG+ST +GIPD
Sbjct: 7 NYASRLKKNNNKGPLGLDELFDTNKQVTKKVNLLYEYLSKSNNTIIHTGAGVSTGSGIPD 66
Query: 64 FRGPNGVWTL 73
FRGP+G+WT+
Sbjct: 67 FRGPSGIWTV 76
>UniRef50_Q73KE1 Cluster: NAD-dependent deacetylase; n=1; Treponema
denticola|Rep: NAD-dependent deacetylase - Treponema
denticola
Length = 251
Score = 96.7 bits (230), Expect = 9e-19
Identities = 72/234 (30%), Positives = 108/234 (46%), Gaps = 28/234 (11%)
Query: 36 LLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSFADA------ 89
L +++ K ++H+V TGAGIST AGI DFRG +G++ K I+V + D
Sbjct: 11 LFSEITK-ARHLVAFTGAGISTLAGIKDFRGKDGLYKQPNTEKMFDIDVFYRDPSVYYGM 69
Query: 90 -----------QPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFI 138
QP H ++QNID LH K+G K + E+HG+ +
Sbjct: 70 AKEFIYGLEEKQPAIVHTVLADLEKRGILKAVITQNIDLLHQKAG--SKNVIEVHGSPSV 127
Query: 139 DECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLM 198
C C +T K VP C + + + +LP+ L+
Sbjct: 128 HYCINCSYTETFEETAKTA--KTGEVPRCPK------CGSPIKPAITFFGEALPQKALMK 179
Query: 199 AEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLL 252
AE +S +D + LGT+L + P+ LP T++ GGK+ I N QPT+ D+ DLL
Sbjct: 180 AETEASKSDFMLVLGTSLLVYPAAALPAYTLRNGGKIAIVNNQPTQFDSYTDLL 233
>UniRef50_A3ZMQ7 Cluster: Sir2 family, possible ADP
ribosyltransferase; n=1; Blastopirellula marina DSM
3645|Rep: Sir2 family, possible ADP ribosyltransferase -
Blastopirellula marina DSM 3645
Length = 252
Score = 95.1 bits (226), Expect = 3e-18
Identities = 75/232 (32%), Positives = 108/232 (46%), Gaps = 25/232 (10%)
Query: 36 LLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTL-----------------EKEGK 78
L+A+ + +S+ V+ TGAGIST +GIPDFR P GVWT E +
Sbjct: 9 LVARWLAESESTVLFTGAGISTESGIPDFRSPGGVWTKYRTIYFDEFRQSAEARREYWRQ 68
Query: 79 KPTINVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFI 138
K +V F+ A P H ++QNIDGLH +G R+ L ELHG
Sbjct: 69 KSEAHVEFSAAAPNAGHQILAAWEAHGVARGLITQNIDGLHQIAG-SRQVL-ELHGTARE 126
Query: 139 DECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLM 198
C C +F P+ ++ VP + TGR L + + LP + L
Sbjct: 127 ATCLDCAARF-EIDPLVVQFRETGEVPPCPNCETGR-----LKHATVSFGQMLPTDVLET 180
Query: 199 AEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKAD 250
A S ADL + +G++L + P+ +LP+ + GG++VI N T D AD
Sbjct: 181 AYDWCSDADLILAIGSSLVVTPAADLPVAVRRRGGRVVILNRDETGLDQIAD 232
>UniRef50_Q8ZU41 Cluster: NAD-dependent deacetylase 1; n=3;
Pyrobaculum|Rep: NAD-dependent deacetylase 1 -
Pyrobaculum aerophilum
Length = 254
Score = 95.1 bits (226), Expect = 3e-18
Identities = 75/248 (30%), Positives = 115/248 (46%), Gaps = 27/248 (10%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGK--------KPT----INV 84
+A L+ S V TGAG+ST++GIPDFRGP GVW K P + V
Sbjct: 13 VASLIARSSCNVALTGAGVSTASGIPDFRGPQGVWRRVDPEKFEISYFYNNPDEVWDLFV 72
Query: 85 SFA----DAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDE 140
+ + +P H ++QN+D LH +G K + ELHG +
Sbjct: 73 KYLLPAFNVKPNPAHYALAEMERLGKLCAVITQNVDRLHQAAG--SKNVIELHGALEYAV 130
Query: 141 CNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAE 200
C C ++ + E + + SG P C G + V+ + LP++ L A
Sbjct: 131 CTNCGSKYALA---EALKWRKSGAPRCPK------CGGVIKPDVVFFGEPLPQDALREAF 181
Query: 201 WHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYYVDDV 260
+ +A++ + +GT+L + P+ LPL K G KLVI N T +D AD +I ++V
Sbjct: 182 MLAEMAEVFMAIGTSLAVYPANQLPLVAKKRGAKLVIINADETYYDFFADYIIRGRAEEV 241
Query: 261 LEKVMDIL 268
L K++D L
Sbjct: 242 LPKLLDRL 249
>UniRef50_A6DC77 Cluster: Silent information regulator protein Sir2;
n=1; Caminibacter mediatlanticus TB-2|Rep: Silent
information regulator protein Sir2 - Caminibacter
mediatlanticus TB-2
Length = 243
Score = 94.3 bits (224), Expect = 5e-18
Identities = 66/228 (28%), Positives = 106/228 (46%), Gaps = 32/228 (14%)
Query: 38 AQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTL--------------EKEGKKPTIN 83
A+++KDSK++V TGAGIS +GIP FRGP G+W+ KE K
Sbjct: 8 AEIIKDSKNLVAFTGAGISVESGIPTFRGPTGLWSKYDPKILDIDFFIQNPKESWKYIKE 67
Query: 84 VSF---ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDE 140
+ + D +P + H ++QNID LH K+G K + E HG E
Sbjct: 68 IFYDYMQDIKPNEAHYFLADLEKKGILKAVITQNIDNLHQKAG--SKNVIEFHGTANKLE 125
Query: 141 CNICKRQFVRSS-PVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMA 199
C CK +F P+E + C C G L + ++ +P+ +
Sbjct: 126 CLNCKSKFNSFEVPLENIPPLCP------------KCNGVLKPDFVFFKEPIPKEAFEKS 173
Query: 200 EWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDN 247
++S AD+ + +GTT +I+P+ LPL + G ++ N++P+ + N
Sbjct: 174 IYYSQNADIMLVIGTTGEIMPASELPLLAKQNGAAIIEINIEPSNYTN 221
>UniRef50_Q8ZT00 Cluster: NAD-dependent deacetylase 2; n=2; cellular
organisms|Rep: NAD-dependent deacetylase 2 - Pyrobaculum
aerophilum
Length = 249
Score = 94.3 bits (224), Expect = 5e-18
Identities = 67/247 (27%), Positives = 115/247 (46%), Gaps = 31/247 (12%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW---------TLEKEGKKPTI----- 82
+A L+ S+H VV TGAGIS +G+P FRGP G+W T E + P +
Sbjct: 3 VADLLASSRHCVVFTGAGISAESGVPTFRGPGGLWERYKPEELATPEAFARDPALVWRWY 62
Query: 83 ---NVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFID 139
+A+P+ H ++QN+DGLH ++G + + ELHG+++
Sbjct: 63 KWRQEVIYNARPSPGHYAIAELEAMGVVRGVITQNVDGLHQRAG--SRLVVELHGSIWRA 120
Query: 140 ECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMA 199
C C ++ PVE V C R C G L V+ + LP+ A
Sbjct: 121 RCVKCGSVYILDKPVEEVPPLC------------RKCGGLLRPDVVWFGEPLPQEAWRAA 168
Query: 200 EWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYYVDD 259
+S++D+ + +GT+ + P+ +P + G ++V N++P+ AD+ I +
Sbjct: 169 VELASVSDVLLVVGTSGVVYPAAYIPRIAKEAGARVVEINVEPSAITPIADVFIQGRAGE 228
Query: 260 VLEKVMD 266
VL ++++
Sbjct: 229 VLPRLVE 235
>UniRef50_A6P1S7 Cluster: Putative uncharacterized protein; n=2;
Bacteria|Rep: Putative uncharacterized protein -
Bacteroides capillosus ATCC 29799
Length = 262
Score = 93.9 bits (223), Expect = 6e-18
Identities = 79/251 (31%), Positives = 114/251 (45%), Gaps = 34/251 (13%)
Query: 30 LNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTI------- 82
+ + LL + + +S IV GAG+ST +GIPDFR +G++ + + TI
Sbjct: 21 MEENRALLQRWIDESSRIVFFGGAGVSTESGIPDFRSVDGLYNQQYDYPPETILSHTFYE 80
Query: 83 ------------NVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLA 130
+ F DAQP H V+QNIDGLH K+G K +
Sbjct: 81 ARPEEFFRFYRNKMLFPDAQPNAAHKKLAELEQAGKLTAMVTQNIDGLHQKAG--SKNVL 138
Query: 131 ELHGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHS 190
ELHG++ + C C + F +E V SGVP C GR+ V+ +E +
Sbjct: 139 ELHGSVLRNYCEKCGKFF----SLEDV-MASSGVPRC------DKCGGRVKPDVVLYEEA 187
Query: 191 LPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKAD 250
L + L A AD+ I GT+L + P+ + L G KLV+ N PT +D AD
Sbjct: 188 LDQQILTAALEAIQKADMLIIGGTSLAVYPAAS--LVNYYRGNKLVLINKSPTPYDRNAD 245
Query: 251 LLINYYVDDVL 261
L+I + VL
Sbjct: 246 LVIAAPIGQVL 256
>UniRef50_A5K3P4 Cluster: Putative uncharacterized protein; n=1;
Plasmodium vivax|Rep: Putative uncharacterized protein -
Plasmodium vivax
Length = 1259
Score = 93.9 bits (223), Expect = 6e-18
Identities = 57/207 (27%), Positives = 100/207 (48%), Gaps = 7/207 (3%)
Query: 67 PNGVWTLEKEGKKPTINVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPR 126
PN + + KK I++ A PTKTH+ ++QNID LH + G
Sbjct: 321 PNEHYVIFGNRKKKVIDLHLA--LPTKTHIMIKELMNRNIIKFLITQNIDSLHYRCGTKF 378
Query: 127 KFLAELHGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLD 186
++E+HGN+FI+ C+ C R+++R + T+ + +G C + P G D +LD
Sbjct: 379 SKISEIHGNIFIERCDFCGRRYLRDFVISTISFQPTGALC---FLCSFPPIGVCTDVLLD 435
Query: 187 WEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVIC--NLQPTK 244
W ++ + L + HS +AD CLG++ IVP+ P + K C N Q +
Sbjct: 436 WNNAYEDFFHLNSIRHSQMADFHFCLGSSFYIVPASYYPSKKKFANEKSFSCLINYQKSS 495
Query: 245 HDNKADLLINYYVDDVLEKVMDILGIE 271
+ DL ++ V+++ + ++ +E
Sbjct: 496 LSKEVDLSLHSNVNNISDVIIKEFSLE 522
Score = 86.2 bits (204), Expect = 1e-15
Identities = 41/75 (54%), Positives = 53/75 (70%), Gaps = 1/75 (1%)
Query: 1 MSC-NYAEGLSPYENKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSA 59
MSC NYA LS ENKG LG E F+ +++ +K L + ++ S+HIVVH GAGISTS+
Sbjct: 1 MSCMNYARRLSKNENKGPLGEKEYFEDSEEEKRKIKKLIEKIRTSEHIVVHAGAGISTSS 60
Query: 60 GIPDFRGPNGVWTLE 74
G+ DFRGP G+WT E
Sbjct: 61 GLQDFRGPTGIWTNE 75
>UniRef50_Q67KQ0 Cluster: NAD-dependent deacetylase; n=1;
Symbiobacterium thermophilum|Rep: NAD-dependent
deacetylase - Symbiobacterium thermophilum
Length = 251
Score = 93.9 bits (223), Expect = 6e-18
Identities = 71/252 (28%), Positives = 121/252 (48%), Gaps = 26/252 (10%)
Query: 38 AQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW---------TLEKEGKKPT-----IN 83
A+ ++ S++ V TGAG ST +G+PDFR G+W ++ ++P
Sbjct: 9 ARALQASRYAVALTGAGASTESGLPDFRSNTGLWKDVDPVSLISMTALRRRPVDFYRFYR 68
Query: 84 VSFAD---AQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDE 140
+ F+ AQP H ++QN+DGLH +G P + ELHG++ +
Sbjct: 69 MRFSHLWGAQPNPVHKVLAALQREGLLKRLITQNVDGLHQAAGSPD--VIELHGSLRECQ 126
Query: 141 CNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAE 200
C C R+F S ++ + + +P C G L GV+ +E +LP + + A
Sbjct: 127 CLRCGRRFP-SRLIDVEVETEADIPRCPE------CGGVLKPGVVLFEEALPADAIEAAI 179
Query: 201 WHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYYVDDV 260
+ ADL + +G++L++ P+ LP+ +++GG+L I NL PT D +A +
Sbjct: 180 EAAMKADLFLVVGSSLEVGPANQLPVLAVQHGGRLAIFNLTPTFLDPRATWIFREKAGQA 239
Query: 261 LEKVMDILGIEI 272
L + LGI +
Sbjct: 240 LGALAAELGISL 251
>UniRef50_Q8N6T7-3 Cluster: Isoform 3 of Q8N6T7 ; n=2;
Catarrhini|Rep: Isoform 3 of Q8N6T7 - Homo sapiens
(Human)
Length = 187
Score = 91.1 bits (216), Expect = 4e-17
Identities = 46/98 (46%), Positives = 58/98 (59%), Gaps = 3/98 (3%)
Query: 117 GLHLKSGVP--RKFLAELHGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTG- 173
G+ SG+P R LAELHGNMF++EC CK Q+VR + V T+G K +G C G
Sbjct: 54 GISTASGIPDFRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGL 113
Query: 174 RPCRGRLYDGVLDWEHSLPENDLLMAEWHSSIADLSIC 211
R CRG L D +LDWE SLP+ DL +A+ S C
Sbjct: 114 RACRGELRDTILDWEDSLPDRDLALADEASRSGPAGTC 151
Score = 81.0 bits (191), Expect = 5e-14
Identities = 39/65 (60%), Positives = 48/65 (73%)
Query: 1 MSCNYAEGLSPYENKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAG 60
MS NYA GLSPY +KG G+PE FD ++L +K LA+LV S +V HTGAGIST++G
Sbjct: 1 MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASG 60
Query: 61 IPDFR 65
IPDFR
Sbjct: 61 IPDFR 65
>UniRef50_Q12Y78 Cluster: Silent information regulator protein Sir2;
n=1; Methanococcoides burtonii DSM 6242|Rep: Silent
information regulator protein Sir2 - Methanococcoides
burtonii (strain DSM 6242)
Length = 245
Score = 90.6 bits (215), Expect = 6e-17
Identities = 76/252 (30%), Positives = 120/252 (47%), Gaps = 28/252 (11%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW---------TLEKEGKKPTINVSFA 87
L L+++S++ VV TGAG+ST +GIPDFRG +GV+ +++ K P + +
Sbjct: 4 LFSLLENSEYCVVLTGAGVSTFSGIPDFRGRSGVYNKFDADLIFSIDHFNKDPAYFYAHS 63
Query: 88 DA--------QPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFID 139
+ QP+ H ++QNID LH K+G K + E+HG+
Sbjct: 64 KSFIYDLEHRQPSIVHSVLSKLEEKGIIKAIITQNIDMLHQKAG--SKNVIEVHGSPQEH 121
Query: 140 ECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMA 199
C C +++ E + K G P C G + ++ + L ++ + A
Sbjct: 122 VCLACGKKYSYEYIAELL--KAEGFPLC------NECGGLVKPDIVFYGEMLRQDTIEKA 173
Query: 200 EWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYYVDD 259
SS ADL + LG+TL + P+ +LPL TI+ GG+LVI N T D A L + + D
Sbjct: 174 IQESSKADLMLVLGSTLVVQPAASLPLYTIENGGELVIVNDMKTPLDGYAKRLYD-DLGD 232
Query: 260 VLEKVMDILGIE 271
V V + I+
Sbjct: 233 VFISVAEYFDID 244
>UniRef50_Q5L014 Cluster: NAD-dependent deacetylase 1; n=7;
Bacillaceae|Rep: NAD-dependent deacetylase 1 -
Geobacillus kaustophilus
Length = 242
Score = 90.2 bits (214), Expect = 7e-17
Identities = 78/244 (31%), Positives = 113/244 (46%), Gaps = 35/244 (14%)
Query: 44 SKHIVVHTGAGISTSAGIPDFRGPN-GVWTLEKEGKKPTINV------SFAD-------- 88
S+H VV TGAG+ST +G+PDFR P G+W + TI+ SF +
Sbjct: 10 SRHTVVLTGAGMSTESGLPDFRSPRTGLWARFNPSELATIDALYHRRESFVEFYQYRIRT 69
Query: 89 ---AQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNICK 145
QP H V+QN+DG H ++G R + ELHG++ C C
Sbjct: 70 LQQCQPHDGHRLLADWERRGIVQTIVTQNVDGFHQEAGSRR--VIELHGSLRTVHCQRCG 127
Query: 146 RQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAEWHSSI 205
K S V H V C G L V+ + LPE + A +
Sbjct: 128 ES------------KPSFV--YLHGVLTCECGGVLRPSVVLFGEPLPEKAITEAWEAAQQ 173
Query: 206 ADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINY-YVDDVLEKV 264
ADL + LG++LQ+ P+ LPL + G KLVI N +PT+ D+ AD +I+ + +VL ++
Sbjct: 174 ADLFLVLGSSLQVSPANQLPLVAKRNGAKLVIINWEPTELDDLADAVIHQRKIGEVLNEL 233
Query: 265 MDIL 268
+ L
Sbjct: 234 NEQL 237
>UniRef50_Q5YR82 Cluster: Putative Sir2 family regulator; n=1;
Nocardia farcinica|Rep: Putative Sir2 family regulator -
Nocardia farcinica
Length = 248
Score = 88.6 bits (210), Expect = 2e-16
Identities = 65/241 (26%), Positives = 111/241 (46%), Gaps = 26/241 (10%)
Query: 44 SKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGK-KPTINVSFAD-------------- 88
S I V TGAGIST +GIPDFRGP GVWT + + T + +D
Sbjct: 9 SGRIGVLTGAGISTDSGIPDFRGPRGVWTEDPIAELMSTYDQYLSDPDLRRRSWLARRAN 68
Query: 89 ----AQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNIC 144
A+P H+ ++QN+D LH ++G + + E+HGNMF C C
Sbjct: 69 PAWQAEPNAGHLALVDLERAGRAVTIITQNVDRLHQRAGSSPQRVVEIHGNMFEVVCVGC 128
Query: 145 KRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAEWHSS 204
+ + + + + +G P A C G L + + L + + A +
Sbjct: 129 DYE---TGMADVLARVEAGEPDPACP----ECGGILKAATIMFGQQLDQRTMTKAALTAQ 181
Query: 205 IADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYYVDDVLEKV 264
+D+ + +GT+LQ+ P+ ++ + G LVI N +PT +D+ A +++ + L ++
Sbjct: 182 TSDIFLAVGTSLQVEPAASMCALAVDAGADLVIVNAEPTPYDSIATEVVHEPIGTALPRL 241
Query: 265 M 265
+
Sbjct: 242 V 242
>UniRef50_A4J646 Cluster: Silent information regulator protein Sir2;
n=2; Peptococcaceae|Rep: Silent information regulator
protein Sir2 - Desulfotomaculum reducens MI-1
Length = 256
Score = 87.4 bits (207), Expect = 5e-16
Identities = 78/258 (30%), Positives = 120/258 (46%), Gaps = 40/258 (15%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPN-GVW---------TLEKEGKKP----TI 82
L +L+K + + TGAGIST +GIPDFR N G+W +++ K P +
Sbjct: 10 LTELIKKAGKTIALTGAGISTESGIPDFRSKNTGLWNQYDPQEVASIQALKKNPESFYAL 69
Query: 83 NVSFAD----AQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFI 138
N + D A+P H ++QNIDGLH +G R + E+HGN+
Sbjct: 70 NFQWWDVCLKAKPNNAHFALARLEKMGWLLGVITQNIDGLHQHAGSKRVW--EVHGNLKG 127
Query: 139 DECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLM 198
C CK+QF +G+ + C C G L V+ + ++PE D M
Sbjct: 128 CSCLSCKKQF-------DMGQLHKQLRCPF-------CGGLLRPDVVLFGDAMPE-DFFM 172
Query: 199 AEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYYVD 258
AE S L + +G++LQ+ P +LP + K VI N +PT D +D++ +
Sbjct: 173 AEKVMSGCQLLLVIGSSLQVYPVASLP----QLSSKTVIINKEPTTWDKHSDVVFHEPAS 228
Query: 259 DVLEKVMDIL-GIEIPSY 275
VL ++D L ++ P Y
Sbjct: 229 QVLCDLVDSLNNLQGPFY 246
>UniRef50_Q8IKW2 Cluster: Putative uncharacterized protein; n=1;
Plasmodium falciparum 3D7|Rep: Putative uncharacterized
protein - Plasmodium falciparum (isolate 3D7)
Length = 1304
Score = 87.4 bits (207), Expect = 5e-16
Identities = 61/224 (27%), Positives = 101/224 (45%), Gaps = 8/224 (3%)
Query: 77 GKKPTINVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNM 136
GK+ + A P+KTH+ ++QNID LH + G AE+HGN+
Sbjct: 238 GKRKKKVIELHLALPSKTHIMINELINKNIIKFMITQNIDSLHHRCGKHFSKTAEIHGNI 297
Query: 137 FIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDL 196
F + C+ C R+++R + T+ K +G C + P G D +LDW +S E
Sbjct: 298 FTERCDFCGRRYLRDYLISTISFKPTGSLC---FLCSFPPIGVCTDVLLDWNNSYEEFFH 354
Query: 197 LMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYY 256
L + HS IAD CLG++ IVP+ + P + C + K ++ +N +
Sbjct: 355 LNSIKHSQIADFHFCLGSSFYIVPASSYPSKKKYANANSYSCVINYQKSFLSKEVNLNIH 414
Query: 257 VDDVLEKVMDILGIEIPSYNESENPMKFAETAIIDWSIDRKDVL 300
V +I I I ++ + ++ A I+ I+ DV+
Sbjct: 415 -----SNVNNISDIIIKEFSLNPLSIRSARITIVRCPINTLDVI 453
Score = 80.2 bits (189), Expect = 8e-14
Identities = 39/75 (52%), Positives = 52/75 (69%), Gaps = 1/75 (1%)
Query: 1 MSC-NYAEGLSPYENKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSA 59
MSC NYA LS E KG LG E F+ ++ +K L + ++ S++IVVH+GAGISTS+
Sbjct: 1 MSCMNYASRLSKNEYKGPLGEEEFFEDTEEEKKKVKELIEKIRSSEYIVVHSGAGISTSS 60
Query: 60 GIPDFRGPNGVWTLE 74
G+ DFRGP G+WT E
Sbjct: 61 GLQDFRGPTGIWTNE 75
>UniRef50_Q7RP35 Cluster: Sir2-like protein; n=5; Plasmodium
(Vinckeia)|Rep: Sir2-like protein - Plasmodium yoelii
yoelii
Length = 1159
Score = 87.4 bits (207), Expect = 5e-16
Identities = 53/180 (29%), Positives = 90/180 (50%), Gaps = 7/180 (3%)
Query: 89 AQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNICKRQF 148
A PTKTH+ ++QNID LH + G ++E+HGN+FI+ C+ C R++
Sbjct: 235 ALPTKTHIMIKELMNKNIIKFLITQNIDSLHYRCGTKFSQISEIHGNIFIERCDFCGRRY 294
Query: 149 VRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAEWHSSIADL 208
+R + T+ K +G C + P G D +LDW ++ + L + HS AD
Sbjct: 295 LRDYVISTISFKPTGSLC---FLCSFPPIGICTDVLLDWNNAYEDFFHLNSIKHSQKADF 351
Query: 209 SICLGTTLQIVPSGNLPLETIKYGGK---LVICNLQPTKHDNKADLLINYYVDDVLEKVM 265
CLG++ IVP+ P + K+ K + N Q + + DL I+ V+++ + ++
Sbjct: 352 HFCLGSSFYIVPASYYPSKK-KFANKNSYSCLINYQKSSLFKELDLNIHSNVNNISDIII 410
Score = 82.2 bits (194), Expect = 2e-14
Identities = 39/75 (52%), Positives = 53/75 (70%), Gaps = 1/75 (1%)
Query: 1 MSCNY-AEGLSPYENKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSA 59
MSC Y A LS ENKG LG E F+ ++ +K +L + ++ S++IVVH+GAGISTS+
Sbjct: 1 MSCMYYASRLSKNENKGPLGEKEYFEDEEEEKEKIKVLIEKIRTSEYIVVHSGAGISTSS 60
Query: 60 GIPDFRGPNGVWTLE 74
G+ DFRGP G+WT E
Sbjct: 61 GLQDFRGPTGIWTNE 75
>UniRef50_Q8CJM9 Cluster: NAD-dependent deacetylase 2; n=3;
Actinomycetales|Rep: NAD-dependent deacetylase 2 -
Streptomyces coelicolor
Length = 241
Score = 87.0 bits (206), Expect = 7e-16
Identities = 64/242 (26%), Positives = 105/242 (43%), Gaps = 26/242 (10%)
Query: 47 IVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKK----------PTI---------NVSFA 87
+ + +GAG+ST +GIPD+RGPNG+W + E +K P I + +
Sbjct: 7 VAILSGAGVSTDSGIPDYRGPNGLWRRDPEAEKLVTYEYYMGDPEIRRRSWLMRRDSAAL 66
Query: 88 DAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNICKRQ 147
A+P H ++QN+DGLH +GV + + ELHG C C +
Sbjct: 67 HAEPNAAHRAVADLERRGVPVRVLTQNVDGLHQLAGVSARKVLELHGTARDCVCTGCGAR 126
Query: 148 FVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAEWHSSIAD 207
+ + + PC C G L + + L L A S
Sbjct: 127 GPMADVLARIEAGEDDPPCL-------DCGGVLKTATVMFGERLDPVVLGEAAAISKACQ 179
Query: 208 LSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYYVDDVLEKVMDI 267
+ + +GT+LQ+ P+ L +++G +LV+ N +PT +D AD +I + L ++
Sbjct: 180 VFVAVGTSLQVEPAAGLARVAVEHGARLVVVNAEPTPYDELADEVIREPIGSALPALLRG 239
Query: 268 LG 269
LG
Sbjct: 240 LG 241
>UniRef50_A1HLU5 Cluster: Silent information regulator protein Sir2;
n=1; Thermosinus carboxydivorans Nor1|Rep: Silent
information regulator protein Sir2 - Thermosinus
carboxydivorans Nor1
Length = 261
Score = 86.2 bits (204), Expect = 1e-15
Identities = 71/253 (28%), Positives = 112/253 (44%), Gaps = 24/253 (9%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW--------TLEKEGKKPTINVSFA- 87
+A + + +IVV TGAG+ST +G+PDFR G+W TL KP F
Sbjct: 9 IAAAWRSANNIVVFTGAGMSTESGLPDFRSKQGLWKDRPETLATLAALKAKPDEFYFFYQ 68
Query: 88 -------DAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDE 140
+ QP H+ V+QN+DGLH ++G + +AELHG +
Sbjct: 69 WRIARLWEVQPNPGHLALAELAQAGFVTKLVTQNVDGLHQRAG--SQGVAELHGTLRTVS 126
Query: 141 CNIC-----KRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPEND 195
C C RQ + + K + R C+G+L V+ + SLP+
Sbjct: 127 CIKCGSQYDSRQMLPHNDTWEEDYKAGRYRHGSECYCPR-CQGQLRPDVVLFGESLPDTA 185
Query: 196 LLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINY 255
A S AD + +G++L + P+ LP ++ G KL+I N T D+ A +I
Sbjct: 186 WNEAVRWSRKADFFVVIGSSLVVSPANYLPQLAVEQGAKLLIINSDSTPLDDAAAWVIRE 245
Query: 256 YVDDVLEKVMDIL 268
+VL + +++
Sbjct: 246 KAGEVLTGIKELI 258
>UniRef50_A7HL19 Cluster: Silent information regulator protein Sir2;
n=1; Fervidobacterium nodosum Rt17-B1|Rep: Silent
information regulator protein Sir2 - Fervidobacterium
nodosum Rt17-B1
Length = 244
Score = 85.4 bits (202), Expect = 2e-15
Identities = 69/249 (27%), Positives = 112/249 (44%), Gaps = 26/249 (10%)
Query: 32 QKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT--------LEKEGKKPTIN 83
++ + L +K+SK V TGAG+S +GIPDFR NGV++ ++ + P
Sbjct: 2 EEILTLVSWLKNSKFTTVLTGAGVSVPSGIPDFRSKNGVYSKWGQEIFDIDLFHQNPDRF 61
Query: 84 VSFA--------DAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGN 135
FA D +P + H ++QNID LH K+G + +AE+HGN
Sbjct: 62 YEFAKQELIKMLDVEPNEIHYLLAYLEKLNIVKGVITQNIDNLHKKAGSQK--VAEIHGN 119
Query: 136 MFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPEND 195
+ C C +++ + C C G ++ + LP N+
Sbjct: 120 VRTWSCLKCGKRYDLFNSQHKEFLIDRNFRCE--------CGGVTKPDIVFFGEMLPLNE 171
Query: 196 LLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINY 255
AE + +D+ I +GT+L + P+ LP+ G KL I N T D+ ADL+I+
Sbjct: 172 YSKAENWAKESDVFIAMGTSLVVYPAAQLPIYAKHSGAKLCIINKNETVLDDYADLVIHI 231
Query: 256 YVDDVLEKV 264
+ D ++V
Sbjct: 232 DLIDFAKEV 240
>UniRef50_A1HU63 Cluster: Silent information regulator protein Sir2;
n=1; Thermosinus carboxydivorans Nor1|Rep: Silent
information regulator protein Sir2 - Thermosinus
carboxydivorans Nor1
Length = 243
Score = 85.4 bits (202), Expect = 2e-15
Identities = 69/232 (29%), Positives = 110/232 (47%), Gaps = 29/232 (12%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGV----------WTLEKEGK-----KPT 81
L + ++ + H V TGAGIST++GIPDFRG N + + + K +P
Sbjct: 10 LVECLRAANHATVLTGAGISTASGIPDFRGINRINADLSQLTSTFMRRQPAKAYELLRPF 69
Query: 82 INVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDEC 141
I A A P H+ ++QNIDGLH ++G + ELHGN++ C
Sbjct: 70 IQTILA-ASPNAAHIGLARLLAKGVLRGLMTQNIDGLHSRAGAG--VVWELHGNLYRGYC 126
Query: 142 NICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAEW 201
C+ ++ + P+ ++ +P +A C L V+ + LP AE
Sbjct: 127 MECRTEYDMNGPLAAFLQR-GQIPTSAC------CGAVLRPDVVFFGDKLPAETWRHAER 179
Query: 202 HSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLI 253
+S +DL + +G+TL++ P+ LP + ++ I NL PT D+KA L I
Sbjct: 180 LASASDLMLVIGSTLEVAPACYLP----ELSREIAIINLGPTAMDHKATLKI 227
>UniRef50_Q97MB4 Cluster: NAD-dependent deacetylase; n=7;
Bacteria|Rep: NAD-dependent deacetylase - Clostridium
acetobutylicum
Length = 245
Score = 85.4 bits (202), Expect = 2e-15
Identities = 80/261 (30%), Positives = 121/261 (46%), Gaps = 43/261 (16%)
Query: 28 DKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW-TLEKEGKKPTINVS- 85
DK+N+ L ++V +S IV GAG+ST + IPDFR NG++ T P + +S
Sbjct: 5 DKINE----LKKIVAESSSIVFFGGAGVSTESNIPDFRSENGLYKTKNNFSYPPEVMLSH 60
Query: 86 -------------------FADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPR 126
F DA+P H V+QNIDGLH +G
Sbjct: 61 TFFKNHTEDFFEFYREKMIFKDAKPNAAHYSLAKIEEQGKLKAIVTQNIDGLHQLAG--S 118
Query: 127 KFLAELHGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLD 186
K + ELHG++ + C C + F +E V K + +P C G + V+
Sbjct: 119 KNVYELHGSIHRNYCMDCGKSF----DLEYVIKSETTIPKCDK------CGGIVKPDVVL 168
Query: 187 WEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKY--GGKLVICNLQPTK 244
+E L ++ + + S AD I GT+L + P+ L I+Y G KL++ N T
Sbjct: 169 YEEGLDDSIIQNSVKAISEADTLIVGGTSLVVYPAAGL----IRYFKGNKLILINKSATA 224
Query: 245 HDNKADLLINYYVDDVLEKVM 265
+DN+ADL+I+ + VLE V+
Sbjct: 225 YDNEADLVISDSIGKVLETVI 245
>UniRef50_A5UYK2 Cluster: Silent information regulator protein Sir2;
n=2; Roseiflexus|Rep: Silent information regulator
protein Sir2 - Roseiflexus sp. RS-1
Length = 261
Score = 84.6 bits (200), Expect = 4e-15
Identities = 67/233 (28%), Positives = 104/233 (44%), Gaps = 28/233 (12%)
Query: 38 AQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINV------SFAD--- 88
A L+ + V TGAGIST +GIPDFRGP+G W + +++ +F D
Sbjct: 15 ADLLGRAHSAVAITGAGISTPSGIPDFRGPDGAWKHVDPSEVASLHNFLRNPRAFYDWFR 74
Query: 89 --------AQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDE 140
A P H ++QN DGLH ++G + ELHG++
Sbjct: 75 PLLDRVLAAAPNAAHYALAALEQHRTLRAIITQNFDGLHQRAGSREVY--ELHGHLRTAT 132
Query: 141 CNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAE 200
C C+RQ + + + + G P C L V+ ++ LP +A
Sbjct: 133 CLECERQIPTQALLPRIRR---GEPPRCS------CGHPLKPDVVLFDEMLPRGLYWLAR 183
Query: 201 WHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLI 253
AD+ I GT+L++ P +LP +++G KL+I N PT D +A+ +I
Sbjct: 184 RAVEHADVIIVAGTSLEVFPVNDLPALGLRHGAKLIIINNGPTYLDGRAEAVI 236
>UniRef50_UPI000049979A Cluster: Sir2 family transcriptional
regulator; n=1; Entamoeba histolytica HM-1:IMSS|Rep:
Sir2 family transcriptional regulator - Entamoeba
histolytica HM-1:IMSS
Length = 319
Score = 82.6 bits (195), Expect = 1e-14
Identities = 72/258 (27%), Positives = 116/258 (44%), Gaps = 25/258 (9%)
Query: 26 SNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW---------TLEKE 76
S +++ C LA+++ SK +VV TGAGIS SAGIPDFR NG+W + E
Sbjct: 9 SEEEIEFSCKSLARIISRSKRLVVLTGAGISVSAGIPDFRSRNGMWKRYEPKVYASYENF 68
Query: 77 GKKPTINVSFAD--------AQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKF 128
KP + + +PTK H ++QN+D LH +G RK
Sbjct: 69 VNKPEMFWKMCNELRNCTEGKKPTKAHFALRKLEEIGKLEEIITQNVDNLHQLAG-SRKV 127
Query: 129 LAELHGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWE 188
+ ELHG I +C C Q + V K G+ C G + V+ +
Sbjct: 128 I-ELHGTGKICQCIKCGYQ----GNADVVLPK--GLIPWIDIPRCPKCGGLIKLDVVLFG 180
Query: 189 HSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNK 248
L + A +S +D+ + +G++L+++P+ LP + + N T+ DN
Sbjct: 181 EQLEKEKFEKAFEVASSSDVFLVIGSSLEVMPANALPRKAKMNSATVAYINKTTTRFDNY 240
Query: 249 ADLLINYYVDDVLEKVMD 266
AD +I D ++ K+++
Sbjct: 241 ADYVIRGESDYLIPKIVE 258
>UniRef50_Q3F1F4 Cluster: SIR2 family protein; n=1; Bacillus
thuringiensis serovar israelensis ATCC 35646|Rep: SIR2
family protein - Bacillus thuringiensis serovar
israelensis ATCC 35646
Length = 241
Score = 81.8 bits (193), Expect = 3e-14
Identities = 73/247 (29%), Positives = 115/247 (46%), Gaps = 33/247 (13%)
Query: 38 AQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGK--------KPTINVSFAD- 88
A+L+K S HIVV TGAGIST +G+PD+R G+W +K + KP FAD
Sbjct: 6 AELIKKSNHIVVLTGAGISTDSGLPDYRSNGGLWDGKKPEEISHFSAVGKPEFVKFFADR 65
Query: 89 ------AQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECN 142
+P K H ++QNID H +G K + E+HG++ C+
Sbjct: 66 MNDISNCKPNKAHEILAKWEEQGKVKSVITQNIDSYHKDAG--SKNVIEMHGHLRNLVCD 123
Query: 143 ICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAEWH 202
C +++ S + C G+ C G + V+ + +LP A
Sbjct: 124 TCSKEYDNSMYTKEDKDNC-GLEW--------ECTGVVRPEVVLFGETLPPLAWHQANEQ 174
Query: 203 SSIADLSICLGTTLQIVPSGNLPLETIKYGGK--LVICNLQPTKHDNKADLLINYYVDDV 260
DL I LGT+LQ+ P +L +E++ Y GK ++I T +D+ A + I D++
Sbjct: 175 MKKTDLVIVLGTSLQVFPFNSL-VESV-YPGKAPVMIITKSDTPYDHMASVRI---YDNI 229
Query: 261 LEKVMDI 267
E +++I
Sbjct: 230 TETLVEI 236
>UniRef50_Q1MT39 Cluster: Novel protein similar to vertebratesirtuin
(Silent mating type information regulation 2 homolog) 7;
n=2; Danio rerio|Rep: Novel protein similar to
vertebratesirtuin (Silent mating type information
regulation 2 homolog) 7 - Danio rerio (Zebrafish)
(Brachydanio rerio)
Length = 376
Score = 81.4 bits (192), Expect = 3e-14
Identities = 37/75 (49%), Positives = 53/75 (70%), Gaps = 1/75 (1%)
Query: 22 EKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPT 81
E FD + L K LA+ V+ +KH+V++TGAGIST+A IPD+RGPNGVWT ++G+ +
Sbjct: 74 EVFDDAENLKTKVKQLAEAVQRAKHLVIYTGAGISTAASIPDYRGPNGVWTQLQKGRSVS 133
Query: 82 INVSFADAQPTKTHM 96
+ + A+PT THM
Sbjct: 134 TS-DLSQAEPTLTHM 147
Score = 42.3 bits (95), Expect = 0.019
Identities = 39/131 (29%), Positives = 61/131 (46%), Gaps = 9/131 (6%)
Query: 170 HVTGRPC---RGRLYDGVLDW-EHSLPENDLLM--AEWHSSIADLSICLGTTLQIVPSGN 223
H TGR C R L D ++ + E E L A + ADL +CLG++L+++ +
Sbjct: 183 HGTGRSCPHCRAELRDTIVHFGERGTLEQPLNWKGAAEAAQRADLILCLGSSLKVLKKYS 242
Query: 224 LPL---ETIKYGGKLVICNLQPTKHDNKADLLINYYVDDVLEKVMDILGIEIPSYNESEN 280
KL I NLQ T DN A L I+ D V+ +M+ L + +P Y+ +
Sbjct: 243 CLWCMNRPASKRPKLYIVNLQWTPKDNLATLKIHGKCDAVMALLMEELALAVPVYSRQGH 302
Query: 281 PMKFAETAIID 291
+ A++D
Sbjct: 303 VKYNMDRAVMD 313
>UniRef50_Q2YZT2 Cluster: Putative uncharacterized protein; n=1;
uncultured delta proteobacterium|Rep: Putative
uncharacterized protein - uncultured delta
proteobacterium
Length = 254
Score = 81.4 bits (192), Expect = 3e-14
Identities = 64/247 (25%), Positives = 111/247 (44%), Gaps = 35/247 (14%)
Query: 39 QLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT---------LEKEGKKPT-------- 81
Q++K SK+++ TGAGIS +GIPDFR P G+W+ ++ + P
Sbjct: 11 QMIK-SKYVIAMTGAGISVESGIPDFRSPGGLWSRFDPFEYAHIDAFKRDPAKVWKMLLE 69
Query: 82 INVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDEC 141
I+ A+P + H ++QNID +H ++G K + E HGN C
Sbjct: 70 IDEVLNQAKPNRAHYALAKLEAAGILKAIITQNIDNMHQRAG--SKNVIEFHGNAETLTC 127
Query: 142 NICKRQFVRSS-PVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAE 200
CK++F R +E++ C C+G + V+ + ++P + MA
Sbjct: 128 TKCKKKFTREEITMESIPPLCE-------------CKGVIRPDVVFFGETIPAHATRMAG 174
Query: 201 WHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNK-ADLLINYYVDD 259
+ + +GT+ + P+ LP++ + G +V NL+ T+ AD I D
Sbjct: 175 KEVEKCAMILVIGTSADVAPASRLPIKAKEGGAIIVEINLRETRLITPIADFRITDKAGD 234
Query: 260 VLEKVMD 266
L K+++
Sbjct: 235 GLMKLVN 241
>UniRef50_Q8U1Q1 Cluster: NAD-dependent deacetylase; n=19; cellular
organisms|Rep: NAD-dependent deacetylase - Pyrococcus
furiosus
Length = 250
Score = 80.6 bits (190), Expect = 6e-14
Identities = 66/249 (26%), Positives = 117/249 (46%), Gaps = 29/249 (11%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW---------TLEKEGKKPTINVSF- 86
+++++ S + TGAGIS +GIP FRG +G+W T E + P + F
Sbjct: 5 VSKILAKSSMAIAFTGAGISAESGIPTFRGKDGLWRKYRAEELATPEAFKRDPKLVWEFY 64
Query: 87 -------ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFID 139
+A+P H+ ++QN+D LH ++G K + ELHGN+F
Sbjct: 65 KWRIKKILEAKPNPAHIALAELEKMGIIKAVITQNVDDLHREAG--SKNVIELHGNIFRV 122
Query: 140 ECNICK-RQFVRSSPVETVGKKCSGVPCAAHHVTGRP-CRGRLYDGVLDWEHSLPENDLL 197
+C C R++++ S + +G S + P C L V+ + +LPE +L
Sbjct: 123 KCTSCSYREYLKES--DRIGWLLS------QELPRCPKCGSLLRPDVVWFGEALPEKELT 174
Query: 198 MAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYYV 257
A + AD+ + +GT+ + P+ +P + GG +V N++P+ AD +
Sbjct: 175 TAFSLAKKADVVLVVGTSGVVYPAAYIPYIVKESGGIVVEINIEPSAITPIADFFLRGKA 234
Query: 258 DDVLEKVMD 266
+VL K+++
Sbjct: 235 GEVLPKLVE 243
>UniRef50_A6PTK3 Cluster: Silent information regulator protein Sir2;
n=1; Victivallis vadensis ATCC BAA-548|Rep: Silent
information regulator protein Sir2 - Victivallis
vadensis ATCC BAA-548
Length = 248
Score = 79.8 bits (188), Expect = 1e-13
Identities = 71/238 (29%), Positives = 107/238 (44%), Gaps = 36/238 (15%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGK-------------KPTIN 83
L Q++++S+ + TGAGIST +GI DFRG NGV+ GK +P +
Sbjct: 5 LKQMLQESRRTLAFTGAGISTLSGIRDFRGKNGVYLEPWHGKSVEEILSLDCFLAEPALF 64
Query: 84 VSFA--------DAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGN 135
+A + P H +QNID LH ++G + + ELHG+
Sbjct: 65 YGWAAEFLYRLEEFHPAAVHRALAGLEQSGLLRGVYTQNIDLLHQQAG--SRHVYELHGS 122
Query: 136 MFIDECNICKRQF--VRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPE 193
C C++QF +P+ GK VP C G + ++ + +L E
Sbjct: 123 PARHHCLKCRKQFGYAEIAPLVLAGK----VPRCG-------CGGLVKPDIVFYGENLDE 171
Query: 194 NDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADL 251
L A A+L + LG++L + P+ +LP+ GGK+VI N QPT D A L
Sbjct: 172 ALLNQAFADMEKAELVLVLGSSLTVQPAASLPMAANYGGGKIVIVNAQPTPLDRYAAL 229
>UniRef50_A7B9E8 Cluster: Putative uncharacterized protein; n=1;
Actinomyces odontolyticus ATCC 17982|Rep: Putative
uncharacterized protein - Actinomyces odontolyticus ATCC
17982
Length = 251
Score = 79.4 bits (187), Expect = 1e-13
Identities = 74/258 (28%), Positives = 105/258 (40%), Gaps = 34/258 (13%)
Query: 30 LNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTI-NVSFAD 88
+N LA + S V GAG+ST +GIPDFRG NG + E+E T+ ++ F +
Sbjct: 1 MNSDVSTLAAWIAASPSTVFFGGAGVSTESGIPDFRGANGFYFQEREIPLETVLSIDFFE 60
Query: 89 ----------------AQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAEL 132
+P H ++QNIDGLH ++G + + EL
Sbjct: 61 RHPQAYWEWFHEIYRPVEPNGAHRALASLEAAGRLDAVITQNIDGLHQRAG--SRAVWEL 118
Query: 133 HGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLP 192
HGN C C V G P C ++ ++ + SL
Sbjct: 119 HGNWERLVCTSCGAVASLGDSVRVDGDPVPACPS---------CASQMRPDIVMYGESLD 169
Query: 193 ENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKY--GGKLVICNLQPTKHDNKAD 250
+ + A S A I GT+L + P+ L I Y G LV+ N PT D AD
Sbjct: 170 QGVIEAAVSAISRASTLIVAGTSLVVYPAAGL----INYFSGDHLVLLNATPTSADAHAD 225
Query: 251 LLINYYVDDVLEKVMDIL 268
L+I V L++VMD L
Sbjct: 226 LIIREPVGATLDRVMDEL 243
>UniRef50_A4VDQ9 Cluster: Chromatin regulatory protein sir2; n=1;
Tetrahymena thermophila SB210|Rep: Chromatin regulatory
protein sir2 - Tetrahymena thermophila SB210
Length = 279
Score = 79.0 bits (186), Expect = 2e-13
Identities = 72/247 (29%), Positives = 109/247 (44%), Gaps = 31/247 (12%)
Query: 45 KHIVVHTGAGISTSAGIPDFRG-----------------PNGVWTLE--KEGKKPTINV- 84
K I+V TGAGIST+AGIPDFR P ++T++ ++ KP +
Sbjct: 31 KKIIVLTGAGISTNAGIPDFRSKDTGLYARLKKSGQFSYPEQIFTIDYYQQNHKPFYEIC 90
Query: 85 -SFA--DAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDEC 141
F + +P ++H ++QNIDGL LK+G+ +K+L + HGN+ C
Sbjct: 91 REFVQKEYEPQQSHKFITELAKQNLLYLNITQNIDGLELKAGLDKKYLIQAHGNLEKSHC 150
Query: 142 NICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAEW 201
C ++ E V K V C + C+G+L V + LP
Sbjct: 151 IECHKEDTIEYFKEGVLKSDDAVNCR----KTKNCQGKLKPSVTFFGEKLPFY-FYKIPL 205
Query: 202 HSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYYVDDVL 261
ADL I +GT+L++ P +L L LV+ N + D L I +D L
Sbjct: 206 QMRFADLIIVMGTSLKVQPFASL-LSYKSKSTPLVVLNSENVVSD--CSLFIGGDIDKNL 262
Query: 262 EKVMDIL 268
E++M L
Sbjct: 263 EEIMQEL 269
>UniRef50_A4M603 Cluster: Silent information regulator protein Sir2;
n=1; Petrotoga mobilis SJ95|Rep: Silent information
regulator protein Sir2 - Petrotoga mobilis SJ95
Length = 256
Score = 78.2 bits (184), Expect = 3e-13
Identities = 66/222 (29%), Positives = 108/222 (48%), Gaps = 35/222 (15%)
Query: 38 AQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT---LEKEGK---------KPTINVS 85
A+L+ +S I V +GAG+ST+AGIPDFRGPNG++T +E + P++
Sbjct: 9 AELIYNSNSIAVLSGAGMSTNAGIPDFRGPNGIYTKANIENPERIFDLDYFYLDPSLFYK 68
Query: 86 F--------ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMF 137
F A+PT TH V+QNID LH K+G K + E+HG +
Sbjct: 69 FHKKFLEYITKAEPTFTHKFLVQLEKEGKLKGIVTQNIDSLHQKAG--SKKVYEIHGGCW 126
Query: 138 IDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLL 197
+ C CKR++ + +E + + VP + C G + ++ + P L
Sbjct: 127 KNYCTKCKRKYSQEEILEKMNNEV--VPKCDN------CGGVIKPDIVFFGE--PVKYLT 176
Query: 198 MAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICN 239
+E ++L + LG++L ++P+ LP T GK+++ N
Sbjct: 177 ESEILMKNSELVLVLGSSLAVIPAAMLPSLT---KGKIIVVN 215
>UniRef50_A6LP94 Cluster: Silent information regulator protein Sir2;
n=1; Thermosipho melanesiensis BI429|Rep: Silent
information regulator protein Sir2 - Thermosipho
melanesiensis BI429
Length = 234
Score = 77.8 bits (183), Expect = 4e-13
Identities = 68/241 (28%), Positives = 113/241 (46%), Gaps = 38/241 (15%)
Query: 41 VKDSKHIVVHTGAGISTSAGIPDFRGPNGVW--------TLEKEGKKPTINVSFADAQPT 92
+ + ++V TGAGISTS+GIPDFR +G++ + E P I + +
Sbjct: 8 ILEEGNVVALTGAGISTSSGIPDFRSEDGLYKEYGYELFSYEFFKNHPDIFYEYIKKEFP 67
Query: 93 K--------THMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNIC 144
K +H ++QNID LH K+G + + ELHGN C C
Sbjct: 68 KMYKANYNMSHKLLAELEEMGYLLGVITQNIDDLHNKAG--SRNVIELHGNATHFYCEEC 125
Query: 145 KRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAEWHSS 204
+R++ S P E + CS C G + ++ + P ND+
Sbjct: 126 ERKY--SFPKEYI---CS-------------CGGLIRPDIVFFGE--PVNDIDRVFELLD 165
Query: 205 IADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYYVDDVLEKV 264
A+ + +GT+LQ+ P+ N P+ + GG L+I N + T++DN AD +++ V++ +KV
Sbjct: 166 KAETLLVMGTSLQVYPASNFPVYVKERGGILIIVNREETQYDNFADFVLHMNVEEFSKKV 225
Query: 265 M 265
+
Sbjct: 226 L 226
>UniRef50_O94066 Cluster: Transcription regulatory protein; n=6;
Saccharomycetales|Rep: Transcription regulatory protein
- Candida albicans (Yeast)
Length = 331
Score = 75.4 bits (177), Expect = 2e-12
Identities = 82/334 (24%), Positives = 148/334 (44%), Gaps = 41/334 (12%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPN----------------GVWTLE--KEGK 78
+A+ VK+ K + GAGIST AGIPDFR P+ V+ ++ KE
Sbjct: 11 VAEAVKNGKKVTFFNGAGISTGAGIPDFRSPDTGLYANLAKLNLPFAEAVFDIDFFKEDP 70
Query: 79 KPTINVSF----ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHG 134
KP ++ + PTK H +QNID L +GV K++ E HG
Sbjct: 71 KPFYTLAEELYPGNFAPTKFHHFIKLLQDQGSLKRVYTQNIDTLERLAGVEDKYIVEAHG 130
Query: 135 NMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPEN 194
+ + C C ++ + + ++T K +P H C G + ++ + LP
Sbjct: 131 SFASNHCVDCHKE-MTTETLKTY-MKDKKIPSCQH------CEGYVKPDIVFFGEGLPVK 182
Query: 195 DLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVIC--NLQPTKHD-NKADL 251
+ E +++I GT+L + P +LP E K ++++ + KH+ K+D+
Sbjct: 183 FFDLWEDDCEDVEVAIVAGTSLTVFPFASLPGEVNKKCLRVLVNKEKVGTFKHEPRKSDI 242
Query: 252 LINYYVDDVLEKVMDILGIEIPSYNE--SENPMKFAETAIIDWSIDRKDVLALEKTFKSK 309
+ + D V EK+ +LG++ NE + +K+++ + + + E+ +
Sbjct: 243 IALHDCDIVAEKLCTLLGLD-DKLNEVYEKEKIKYSKAETKETKMHEIEDKLKEEAHLKE 301
Query: 310 CKGVKKKRILIKTKRFTSNANDIEKSKMI-KLEV 342
K K + K ++AND E ++I KL++
Sbjct: 302 DKHTTK----VDNKEKQNDANDKELEQLIDKLKI 331
>UniRef50_Q86ED3 Cluster: Clone ZZD513 mRNA sequence; n=2;
Schistosoma japonicum|Rep: Clone ZZD513 mRNA sequence -
Schistosoma japonicum (Blood fluke)
Length = 225
Score = 74.9 bits (176), Expect = 3e-12
Identities = 53/140 (37%), Positives = 72/140 (51%), Gaps = 23/140 (16%)
Query: 157 VGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAEWHSSIADLSICLGTTL 216
+G + S V C R CRG+L+D +LDWE LP + +A HS ADL IC+G++L
Sbjct: 1 MGLRQSSVTCNYLKPNNRYCRGKLHDTILDWEDDLPVWIITLAIEHSKKADLHICIGSSL 60
Query: 217 QIVPSGNLPL----ETIKYG-------------------GKLVICNLQPTKHDNKADLLI 253
QI P+ + PL +T+K G KLVI NLQPTK A L I
Sbjct: 61 QIFPAASFPLINACKTVKGGSTNDIQTDHKNNDSTHNLNSKLVIINLQPTKMAKYATLNI 120
Query: 254 NYYVDDVLEKVMDILGIEIP 273
N D V++ + + L I +P
Sbjct: 121 NAPADLVMKILCEKLDIVVP 140
>UniRef50_O07595 Cluster: NAD-dependent deacetylase; n=3;
Bacillus|Rep: NAD-dependent deacetylase - Bacillus
subtilis
Length = 247
Score = 74.9 bits (176), Expect = 3e-12
Identities = 65/242 (26%), Positives = 115/242 (47%), Gaps = 32/242 (13%)
Query: 40 LVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSF------------- 86
++ +++ IVV TGAG+ST +GIPDFR G+WT E + +++ +
Sbjct: 7 ILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWT-EDASRMEAMSLDYFLSYPRLFWPKFK 65
Query: 87 --------ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFI 138
+P + H+ +QNIDGLH K+G + + ELHG++
Sbjct: 66 ELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNIDGLHKKAG--SRHVYELHGSIQT 123
Query: 139 DECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLM 198
C C ++ +E +C+ AA + G C L V+ + ++ D L
Sbjct: 124 AACPACGARYDLPHLLEREVPECT----AAGN-NGDICGTVLKTDVVLFGDAVMHFDTLY 178
Query: 199 AEWHSSIADLSICLGTTLQIVPSGNLPLE-TIKYGGKLVICNLQPTKHDNKADLLINYYV 257
+ ADL + +GT+L++ P+ +P + ++ G K VI NL+PT D+ D++I+ +
Sbjct: 179 EKLDQ--ADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIINLEPTYCDSLFDMVIHQKI 236
Query: 258 DD 259
+
Sbjct: 237 GE 238
>UniRef50_Q8R984 Cluster: NAD-dependent deacetylase 2; n=1;
Thermoanaerobacter tengcongensis|Rep: NAD-dependent
deacetylase 2 - Thermoanaerobacter tengcongensis
Length = 250
Score = 74.5 bits (175), Expect = 4e-12
Identities = 74/250 (29%), Positives = 106/250 (42%), Gaps = 34/250 (13%)
Query: 38 AQLVKDSKHIVVHTGAGISTSAGIPDFRGPN-GVWT----LEKEGKKPTINV-------- 84
A+L+K S+ +V TGAGIST +GIPDFR P G+W E K N
Sbjct: 14 AELIKSSQKTMVLTGAGISTESGIPDFRSPGTGLWENMDPTEVLSTKVLFNSPEEFYRVG 73
Query: 85 -----SFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFID 139
S +A+P + H ++QNID LH K+G K + E+HGN
Sbjct: 74 FKILSSMRNAEPNEAHYILSEMEKEGIIAGVITQNIDNLHQKAG--SKKVYEVHGNTREG 131
Query: 140 ECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPEN-DLLM 198
C C + E V K+ C C G L V+ + +P DL +
Sbjct: 132 SCLRCGEKVSFELLEEKVAKEEIPPRCDR-------CGGMLRPDVVLFGDPMPHAFDLAL 184
Query: 199 AEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYYVD 258
E S DL I +G++L + P LP L+I N T +D KAD++I
Sbjct: 185 KEVQES--DLLIVIGSSLVVAPVNFLP----GMVDGLIIINATETPYDYKADVVIREKAS 238
Query: 259 DVLEKVMDIL 268
L + +++
Sbjct: 239 YALRNIWNLI 248
>UniRef50_UPI000049971A Cluster: Sir2 family transcriptional
regulator; n=1; Entamoeba histolytica HM-1:IMSS|Rep:
Sir2 family transcriptional regulator - Entamoeba
histolytica HM-1:IMSS
Length = 285
Score = 74.1 bits (174), Expect = 5e-12
Identities = 62/253 (24%), Positives = 105/253 (41%), Gaps = 22/253 (8%)
Query: 27 NDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW------------TLE 74
+D ++ ++A+ ++ SK++ V TGAGIS +GIPDFR NG+W +
Sbjct: 18 DDSIDIDIEMIARSMEKSKNVTVLTGAGISVESGIPDFRSSNGLWKRYDPSVYGSYSNFK 77
Query: 75 KEGK---KPTINVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAE 131
K + K T + A P H V+QN+DGLH ++G K + E
Sbjct: 78 KHPELFWKMTEEIHKITAYPNHVHEALAELEKIGVVKTIVTQNVDGLHQQAG--SKNVVE 135
Query: 132 LHGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSL 191
+HG+ C C ++ + + K C C G L V+ + L
Sbjct: 136 MHGSGRACYCIDC--DYISRADDDIWSKPVPPSQCIPR---CPKCGGLLKLDVVLFGEKL 190
Query: 192 PENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADL 251
S+ D + +GT+LQ+ P +P G ++ N T D AD
Sbjct: 191 DRVTYDEVVEASTKTDFLLVIGTSLQVAPCNIIPFRAKHCGAQVAFINCSKTPMDEYADF 250
Query: 252 LINYYVDDVLEKV 264
++ + +++ K+
Sbjct: 251 VVRGDLKEIVPKI 263
>UniRef50_Q899G3 Cluster: NAD-dependent deacetylase; n=19; cellular
organisms|Rep: NAD-dependent deacetylase - Clostridium
tetani
Length = 247
Score = 74.1 bits (174), Expect = 5e-12
Identities = 73/256 (28%), Positives = 114/256 (44%), Gaps = 39/256 (15%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW-TLEKEGKKPTINVS---------- 85
L +L+K S +IV GAG+ST + IPDFR G++ T P + +S
Sbjct: 7 LKELIKSSSNIVFFGGAGVSTESNIPDFRSEEGLYKTKSNFSYSPEVMLSHSFFKEHTED 66
Query: 86 FAD----------AQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGN 135
F D A+P H ++QNIDGLH +G K + ELHG
Sbjct: 67 FFDFYKEKMIYKYAKPNLAHHALAKLEKVGKLKAIITQNIDGLHQLAG--SKNVIELHGG 124
Query: 136 MFIDECNICKRQFVRSSPVET--VGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPE 193
+ + C C + F + + V KC C G + V+ +E L
Sbjct: 125 VGRNYCMDCNKFFDLNYILNNKEVVPKCD------------VCGGIVKPDVVLYEEPLNM 172
Query: 194 NDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLI 253
+++ A + +D+ I GT+L + P+ NL + K G KLV+ N T +D KA ++I
Sbjct: 173 DNINNAVRYVENSDVLIVGGTSLVVYPAANL-IHYYK-GNKLVLINKSSTPYDRKAQIVI 230
Query: 254 NYYVDDVLEKVMDILG 269
N + +L +++ LG
Sbjct: 231 NDSIGSILGGIVEELG 246
>UniRef50_A7DQD6 Cluster: Silent information regulator protein Sir2;
n=1; Candidatus Nitrosopumilus maritimus SCM1|Rep:
Silent information regulator protein Sir2 - Candidatus
Nitrosopumilus maritimus SCM1
Length = 242
Score = 73.7 bits (173), Expect = 7e-12
Identities = 66/230 (28%), Positives = 102/230 (44%), Gaps = 33/230 (14%)
Query: 41 VKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSFAD------------ 88
VK++K IV TGAGIS +GIP FRG +G+W K TI+ + D
Sbjct: 11 VKNAKKIVFVTGAGISQESGIPTFRGKDGLWRNYDAMKLATIDAFYDDPKLVWEWYNERR 70
Query: 89 -----AQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNI 143
A P + H ++QNIDGLH K+G + + ELHG++ +C +
Sbjct: 71 HNIFSANPNQGH-KAIAELEKFADVVSLTQNIDGLHQKAGSTK--VLELHGSIVKIKCTV 127
Query: 144 CKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAEWHS 203
C E + P C L V+ + SLP++ A H+
Sbjct: 128 C------DFSDEIMTDFTENPPLC-------KCGSILRPDVVWFGESLPQDVWQEAIIHA 174
Query: 204 SIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLI 253
+ DL I +GT+L + P+ LP+ + L+ N + T+ ++ DL+I
Sbjct: 175 NQCDLMIIVGTSLVVSPANTLPIYAKQNNAMLIEINPENTEMSSEMDLVI 224
>UniRef50_Q88BY5 Cluster: NAD-dependent deacetylase; n=9;
Bacteria|Rep: NAD-dependent deacetylase - Pseudomonas
putida (strain KT2440)
Length = 262
Score = 73.3 bits (172), Expect = 9e-12
Identities = 65/251 (25%), Positives = 108/251 (43%), Gaps = 24/251 (9%)
Query: 38 AQLVKDSKHIVVHTGAGISTSAGIPDFRGP-NGVW---------TLEKEGKKPTINVSF- 86
A+ ++ SK +V TGAGIS +GIP FR G+W T + PT+ S+
Sbjct: 8 AEALRRSKTVVFFTGAGISADSGIPTFRDKLTGLWAKHDPQRLETADAFRANPTLVWSWY 67
Query: 87 -------ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFID 139
+ A+P H+ V+QNID LH ++G + LHG++
Sbjct: 68 LWRRHQVSQAKPNSAHLSIPQLADAGWDVSVVTQNIDDLHERAGSSP--VVHLHGSLMDV 125
Query: 140 ECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMA 199
+C C R SP + + G T C GRL GV+ + +LP+N A
Sbjct: 126 KCFGCHRP-AELSP-DQLAVPLEGQLIEPPRCTR--CNGRLRPGVVWFRENLPDNAWRSA 181
Query: 200 EWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYYVDD 259
DL + +GT+ ++P+ +P + G ++ NL+ D ++++
Sbjct: 182 VRLVRACDLLVSVGTSGVVMPAAGIPDMALAVGATVIHVNLEDVGMDGADEIMLEGPAGV 241
Query: 260 VLEKVMDILGI 270
VL ++ G+
Sbjct: 242 VLPALLQATGV 252
>UniRef50_A1CD03 Cluster: SIR2 family histone deacetylase, putative;
n=2; Trichocomaceae|Rep: SIR2 family histone
deacetylase, putative - Aspergillus clavatus
Length = 329
Score = 70.9 bits (166), Expect = 5e-11
Identities = 82/282 (29%), Positives = 115/282 (40%), Gaps = 34/282 (12%)
Query: 37 LAQLVKDS--KHIVVHTGAGISTSAGIPDFRGPN-GVWTLEKEGKKP------------- 80
+A L+K + IVV GAGIST+AGIPDFR P G++ K P
Sbjct: 7 IATLIKSGQIRRIVVLVGAGISTAAGIPDFRSPETGIYDRLKPLGLPYPEAIFHINYFRH 66
Query: 81 TINVSFADAQ--------PTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAEL 132
T +A A+ PT TH +QNIDGL +GVP +
Sbjct: 67 TPEPFYAIARARHPRTLKPTITHAFLALLAKKNLLHFLFTQNIDGLERDTGVPENKILNA 126
Query: 133 HGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLP 192
HG+ C CK + E + K GV + C G + V+ + SLP
Sbjct: 127 HGSWRTQHCWKCKTSYPDDLMKEAIAK---GV---VPYCQVPDCGGPIKPDVVFFGQSLP 180
Query: 193 ENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKH--DNKAD 250
+ E ADL I +GT+L++ P LP + ++ G V+ N + D
Sbjct: 181 A-EFEDEEKKVPEADLMIVMGTSLKVAPCSRLPGQ-VREGVPRVLINREKAGDVGVRPND 238
Query: 251 LLINYYVDDVLEKVMDILGIEIPSYNESENPMKFAETAIIDW 292
L I DD + K+ DILG + E+ + E DW
Sbjct: 239 LCILGDCDDGVRKLADILGWTEEMEDVWEDAVAAKEATQDDW 280
>UniRef50_Q23E36 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Tetrahymena thermophila SB210|Rep:
Transcriptional regulator, Sir2 family protein -
Tetrahymena thermophila SB210
Length = 1348
Score = 70.5 bits (165), Expect = 6e-11
Identities = 71/254 (27%), Positives = 112/254 (44%), Gaps = 32/254 (12%)
Query: 42 KDSKHIVVHTGAGISTSAGIPDFRGPNGVWT------LE-----------KEGKKP--TI 82
K +I+ TGAGISTS+GIPDFR PNG+++ LE + + P +
Sbjct: 18 KQINNILFLTGAGISTSSGIPDFRSPNGLYSKVQKYKLEYPEQIFEIKYFTKNQMPFYEM 77
Query: 83 NVSFADAQP--TKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDE 140
+ F +P T H SQN+DGL L++G+P + L ++HGN
Sbjct: 78 DKEFFSNKPHFTSAHYFMAEVNRREQLLFVFSQNVDGLELEAGLPPEKLCQVHGNYRGAR 137
Query: 141 CNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPC-RGRLYDGVLDWEHSLPENDLLMA 199
C C + + E V K+ C C RG + V+ + SL +
Sbjct: 138 CQKCGFKHDINKYKEFVQKQVI-YKC-------ENCKRGPVRPNVVFFGESL-DKGFTKN 188
Query: 200 EWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYYVDD 259
+ + AD +GT++Q+ P NL +E I +++ N K + + +DD
Sbjct: 189 TYKIAAADCVFIMGTSMQVAPF-NLTVEKISKNVPVIVINRDMVYLPYKKYIHLKNDIDD 247
Query: 260 VLEKVMDILGIEIP 273
+EK+M LG + P
Sbjct: 248 NIEKLMTDLGWDFP 261
>UniRef50_Q0R0H8 Cluster: Sir2-like protein; n=1; Naegleria sp.
TES-2005|Rep: Sir2-like protein - Naegleria sp. TES-2005
Length = 137
Score = 68.1 bits (159), Expect = 3e-10
Identities = 41/128 (32%), Positives = 66/128 (51%), Gaps = 8/128 (6%)
Query: 144 CKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCR--GRLYDGVLDWEHSLPENDLLMAEW 201
C+R+++R V C V H TGR C G L D ++ + +LP N+L +A
Sbjct: 1 CEREYLRGFDV------CKTVANFRDHKTGRKCECGGDLRDTIIHFGENLPINELNIAYK 54
Query: 202 HSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYYVDDVL 261
+S + D ++ +GT+L + P+ LP ++ GG + I NLQ T D A + D+ +
Sbjct: 55 NSQMGDFALVMGTSLMVNPAAALPGMVLENGGSMCIVNLQKTPFDGSARVRAYAKTDEFM 114
Query: 262 EKVMDILG 269
VM+ LG
Sbjct: 115 RYVMEELG 122
>UniRef50_A2QFF9 Cluster: Complex: Sir2p is one of four Silent
Information Regulator genes in yeast. Sir2p; n=6;
Pezizomycotina|Rep: Complex: Sir2p is one of four Silent
Information Regulator genes in yeast. Sir2p -
Aspergillus niger
Length = 378
Score = 68.1 bits (159), Expect = 3e-10
Identities = 64/222 (28%), Positives = 94/222 (42%), Gaps = 32/222 (14%)
Query: 42 KDSKHIVVHTGAGISTSAGIPDFRGPN-GVWT----LEKEGKKPTINVSF---------- 86
K K +VV GAGISTSAGIPDFR P+ G+++ L+ + ++SF
Sbjct: 33 KPVKRVVVMVGAGISTSAGIPDFRSPDTGIYSNLAHLDLPDPEAVFDISFFRQNPRPFYA 92
Query: 87 -------ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFID 139
+PT H SQNID L +GVP + E HG+
Sbjct: 93 LARELAPGQFRPTIAHSFIKLLYDKGMLLKHFSQNIDCLERLAGVPGDKIVEAHGSFATQ 152
Query: 140 ECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMA 199
C CK ++ + + K VP C+G + ++ + SLP D
Sbjct: 153 HCIDCKAEYPEDLMKKAITK--GKVPYCTQ------CKGLVKPDIVFFGESLPA-DFFDN 203
Query: 200 EWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQ 241
ADL I +GT+LQ+ P +LP + G V+ N++
Sbjct: 204 RDLPEQADLCIVMGTSLQVQPFASLP-AFVSDGVPRVLINME 244
>UniRef50_A6TNA0 Cluster: Silent information regulator protein Sir2;
n=1; Alkaliphilus metalliredigens QYMF|Rep: Silent
information regulator protein Sir2 - Alkaliphilus
metalliredigens QYMF
Length = 249
Score = 67.3 bits (157), Expect = 6e-10
Identities = 72/256 (28%), Positives = 105/256 (41%), Gaps = 39/256 (15%)
Query: 26 SNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW---------TLEKE 76
+ +++ + LA L+K SK V+ TGAG+ T + IPDFR G W ++
Sbjct: 6 NGERMKDGVIKLASLIKKSKDTVILTGAGMDTESNIPDFRSEKGWWRSIDPRTVANIDTF 65
Query: 77 GKKPTINVSFAD--------AQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKF 128
+ ++ F D QP K H +QN+ GLH+ +G +
Sbjct: 66 YENYSLFHEFYDMRLRLLVGIQPHKGHYILSDLEKKGMIRSIATQNVAGLHVMAGSQNVY 125
Query: 129 LAELHGNMFIDECNICKRQ--FVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLD 186
ELHGN+ CN C + R VET G C +G L V+
Sbjct: 126 --ELHGNIRKIRCNNCNHEASLERFLAVETCG-SCGD-------------KG-LRPSVIL 168
Query: 187 WEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHD 246
+ +LP A DL I +GT+L++ P +LP+ T GK V N + D
Sbjct: 169 FGETLPPKAWDSALRDIQKCDLLIVIGTSLEVYPVNHLPMLT---KGKKVFINNEERSTD 225
Query: 247 NKADLLINYYVDDVLE 262
DL I +VLE
Sbjct: 226 YAFDLTIIGKAKEVLE 241
>UniRef50_Q9USN7 Cluster: Sir2 family histone deacetylase Hst2; n=1;
Schizosaccharomyces pombe|Rep: Sir2 family histone
deacetylase Hst2 - Schizosaccharomyces pombe (Fission
yeast)
Length = 332
Score = 67.3 bits (157), Expect = 6e-10
Identities = 70/263 (26%), Positives = 110/263 (41%), Gaps = 43/263 (16%)
Query: 37 LAQLVKDSK--HIVVHTGAGISTSAGIPDFRGPN----------------GVWTLEKEGK 78
+A L+K+ K I V GAGIST+AGIPDFR P V+ L K
Sbjct: 18 VASLIKEGKVKKICVMVGAGISTAAGIPDFRSPETGIYNNLQRFNLPYAEAVFDLSYFRK 77
Query: 79 KPTINVSFADA------QPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAEL 132
P A +PT TH +QNID L +GVP K L E
Sbjct: 78 NPRPFYELAHELMPEKYRPTYTHYFIRLLHDKRLLQKCYTQNIDTLERLAGVPDKALIEA 137
Query: 133 HGNMFIDECNIC----KRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWE 188
HG+ C C + ++VR+ ++ KC+ C+G + ++ +
Sbjct: 138 HGSFQYSRCIECYEMAETEYVRACIMQKQVPKCNS------------CKGLIKPMIVFYG 185
Query: 189 HSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKH--D 246
LP E + + D+++ +GT+L + P +LP E + + V+ N +P +
Sbjct: 186 EGLPMRFFEHMEKDTKVCDMALVIGTSLLVHPFADLP-EIVPNKCQRVLINREPAGDFGE 244
Query: 247 NKADLLINYYVDDVLEKVMDILG 269
K D++I D + + +LG
Sbjct: 245 RKKDIMILGDCDSQVRALCKLLG 267
>UniRef50_Q8CNF4 Cluster: NAD-dependent deacetylase; n=17;
Staphylococcus|Rep: NAD-dependent deacetylase -
Staphylococcus epidermidis (strain ATCC 12228)
Length = 246
Score = 67.3 bits (157), Expect = 6e-10
Identities = 65/251 (25%), Positives = 106/251 (42%), Gaps = 37/251 (14%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW-TLEKEGKKPTINVS---------- 85
L +V +S IV TGAG+S ++GIPDFR G++ + K+G+ P +S
Sbjct: 9 LKDIVNNSNQIVFFTGAGVSVASGIPDFRSMGGLYDEISKDGQSPEYLLSIDHLHDNKES 68
Query: 86 ----------FADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGN 135
AD +P H ++QNIDGLH +G + ELHG
Sbjct: 69 FINFYHERLLIADKKPNIVHQWIAQLENQQKSLGVITQNIDGLHEDAGSHN--IDELHGT 126
Query: 136 MFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPEND 195
+ C C ++ +S + K C C + ++ + L +
Sbjct: 127 LNRFYCINCYEEYSKSYVMTHHLKYC------------EKCGNVIRPDIVLYGEMLNQKT 174
Query: 196 LLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINY 255
+ A AD I LG++L + P+ E G LVI N T +D+ A L+I+
Sbjct: 175 VFKALDKIQHADTLIVLGSSLVVQPAAGFVSEF--KGDNLVIINRDATPYDHTASLVIHD 232
Query: 256 YVDDVLEKVMD 266
+ V+E++++
Sbjct: 233 DMTSVIEEIVN 243
>UniRef50_Q9I4L0 Cluster: NAD-dependent deacetylase 1; n=10;
Bacteria|Rep: NAD-dependent deacetylase 1 - Pseudomonas
aeruginosa
Length = 250
Score = 67.3 bits (157), Expect = 6e-10
Identities = 59/230 (25%), Positives = 99/230 (43%), Gaps = 32/230 (13%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGP-NGVWTLEKEGKKPTINVSFAD------- 88
+ +L+ ++ +V+ TGAG+S +GIP FR G+W T +FAD
Sbjct: 4 VVELLAGARRLVIFTGAGVSAESGIPTFRDALGGLWARYDPAALAT-PAAFADDPALVWG 62
Query: 89 -----------AQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMF 137
QP H V+QN+D LH ++G + + LHG++
Sbjct: 63 WYEWRRLKVLGVQPNPAHRAIAALSGRIANTRLVTQNVDDLHERAG--SRDVLHLHGSLH 120
Query: 138 IDECNICKRQFVRSSP--VETV-GKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPEN 194
C C + + P VE G++ C A C G++ GV+ + +LPE
Sbjct: 121 APRCATCAAAYRDALPDSVEPEEGRRIEPPRCPA-------CGGQVRPGVVWFGEALPEA 173
Query: 195 DLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTK 244
L A + DL + +GT+ + P+ +P +++G +V N QP +
Sbjct: 174 ALREAFAAACECDLLLSVGTSGVVQPAARIPGLALEHGASVVHVNPQPVR 223
>UniRef50_A4QUX8 Cluster: Putative uncharacterized protein; n=1;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 460
Score = 66.5 bits (155), Expect = 1e-09
Identities = 69/250 (27%), Positives = 111/250 (44%), Gaps = 36/250 (14%)
Query: 45 KHIVVHTGAGISTSAGIPDFRGPN-GVWTLEKEGKKP----TINVSF------------- 86
K I V TGAGIST+AGIPDFR P G+++ + K P ++SF
Sbjct: 40 KRITVMTGAGISTAAGIPDFRSPGTGLYSNLERLKLPEPEAVFDISFFRDRPEPFYVLAK 99
Query: 87 ----ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECN 142
QPT +H +QNID L ++GVP + + E HG+ C
Sbjct: 100 ELYPGKFQPTISHAFIALLSKKGLLQMNFTQNIDCLERQAGVPGEKVIEAHGSFATQSCI 159
Query: 143 ICKRQFVRSSPVETVGKKCSGVP-CAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAEW 201
CK F + V K+ VP CA+ C G + ++ + LP +
Sbjct: 160 ECKELFPDDEMLLHVEKEI--VPRCAS-------CNGLVKPNIVFFGEPLPRT--FSEKC 208
Query: 202 H-SSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINY-YVDD 259
H + +DL+I +GT+L + P LP + +L++ ++ + ++D ++ D
Sbjct: 209 HLVAESDLAIIIGTSLTVYPFAGLPELVPRGSPRLLLNKVRVGQIGTRSDDVVELGSCDA 268
Query: 260 VLEKVMDILG 269
+ K+ D+LG
Sbjct: 269 GVRKLADLLG 278
>UniRef50_A1DG07 Cluster: SIR2 family histone deacetylase, putative;
n=3; Trichocomaceae|Rep: SIR2 family histone
deacetylase, putative - Neosartorya fischeri (strain
ATCC 1020 / DSM 3700 / NRRL 181)(Aspergillus
fischerianus (strain ATCC 1020 / DSM 3700 / NRRL 181))
Length = 425
Score = 66.1 bits (154), Expect = 1e-09
Identities = 76/273 (27%), Positives = 112/273 (41%), Gaps = 36/273 (13%)
Query: 42 KDSKHIVVHTGAGISTSAGIPDFRGPN-GVWT----LEKEGKKPTINVSF---------- 86
KD + IVV GAGISTSAGIPDFR P+ G+++ L+ + ++S+
Sbjct: 33 KDVRRIVVMVGAGISTSAGIPDFRSPDTGLYSNLAFLDLPEPEDVFDISYFRENPRPFYA 92
Query: 87 -------ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFID 139
+PT H +QNID L +GVP + + E HG+
Sbjct: 93 LARELAPGRYRPTIAHSFVKLLHDKGLLLKHFTQNIDCLERLAGVPGEKIVEAHGSFASQ 152
Query: 140 ECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMA 199
C CK + E + K VP H C G + ++ + +LPE +
Sbjct: 153 HCIDCKAAYPEPQMKEAIAK--GEVPHCPH------CNGFVKPDIVFFGEALPE-EFHAN 203
Query: 200 EWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPT--KHDNKADLLINYYV 257
ADL I +GT+L + P +LP + G V+ N++ D+L+
Sbjct: 204 RSLPEQADLCIVMGTSLTVHPFASLP-SFCREGVPRVLINMERVGGMGSRPDDVLLLGDC 262
Query: 258 DDVLEKVMDILG--IEIPSYNESENPMKFAETA 288
D + K LG E+ E NP K A A
Sbjct: 263 DAGVRKFARALGWEQELEELWERTNPDKEAREA 295
>UniRef50_A2F9H1 Cluster: Transcriptional regulator, Sir2 family
protein; n=2; Trichomonas vaginalis|Rep: Transcriptional
regulator, Sir2 family protein - Trichomonas vaginalis
G3
Length = 304
Score = 65.7 bits (153), Expect = 2e-09
Identities = 58/204 (28%), Positives = 89/204 (43%), Gaps = 28/204 (13%)
Query: 44 SKHIVVHTGAGISTSAGIPDFRG----------------PNGVWTLE--KEGKKPTINVS 85
+K I+ TGAGIST+AGIPDFR P+ V+ ++ KE ++P ++
Sbjct: 24 AKKIIFLTGAGISTAAGIPDFRSIGTGFYSNLQKYNLPEPSDVFNIKYFKENQEPFYDLC 83
Query: 86 FA----DAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDEC 141
+ +PT H +QNIDGL +GVP L E HG C
Sbjct: 84 PSLLPGKYKPTFIHYFGAYMAKKGILLKQYTQNIDGLERIAGVPEDKLVESHGTFSTAHC 143
Query: 142 NICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAEW 201
CK+++ E K G P H T C+G + ++ + +LP + A
Sbjct: 144 TECKKEWKLE---EIRDKLLLGKPL---HCTDPDCKGFIKPDIVFFGENLPTSFQHNARI 197
Query: 202 HSSIADLSICLGTTLQIVPSGNLP 225
D+ + GT+L++ P +LP
Sbjct: 198 DLRSCDMLLISGTSLKVNPFASLP 221
>UniRef50_Q750H1 Cluster: AGL018Cp; n=1; Eremothecium gossypii|Rep:
AGL018Cp - Ashbya gossypii (Yeast) (Eremothecium
gossypii)
Length = 340
Score = 65.7 bits (153), Expect = 2e-09
Identities = 83/331 (25%), Positives = 137/331 (41%), Gaps = 48/331 (14%)
Query: 47 IVVHTGAGISTSAGIPDFRGPN-GVWTLEKEGKKPTINVSFA------DAQPTKT----- 94
+V GAGISTS GIPDFR PN G++ + K P FA D +P T
Sbjct: 24 VVFLVGAGISTSCGIPDFRSPNTGLYHNLSKFKLPYAEAVFAIDYFQRDPKPFYTLAREM 83
Query: 95 ----------HMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNIC 144
H +QNID L ++G+ ++ E HG+ + C C
Sbjct: 84 YPGKYIPSRFHYLMKLFESKGYLKAVYTQNIDTLEREAGIAADYIIEAHGSFATNHCIDC 143
Query: 145 KRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPEN-----DLLMA 199
+ F P ET + + C G + ++ + LP D L++
Sbjct: 144 DKTF----PTETFKAMLE----SGEYARCEDCEGLIKPRIVFFGEDLPSVFYTSWDKLLS 195
Query: 200 EWHSSIAD-LSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPT---KHDNKADLLINY 255
E + D L I GT+L + P +LP ET + + V+ N++ K K D++I+
Sbjct: 196 EMQAGKEDYLVIVAGTSLVVYPFASLPSETPRKVHR-VLMNMEVVGDFKTPRKTDIIIHG 254
Query: 256 YVDDVLEKVMDILGIEIPSYNESENPMKFAETAIIDWSIDRKDVLALEKTFKSKCKGVKK 315
D + E++ LG + + +ET +++ KD + KS V K
Sbjct: 255 ETDHIAEELARALG-WYDELVDISSGRSSSETTVVE-----KDT-ENQTDIKSASASVIK 307
Query: 316 KRILIKTKRFTSNANDIEKSKMIKLEVKEEN 346
+ + + S+ + I + K++KL++ EN
Sbjct: 308 YKEVSSVSKEESSIDKIAE-KILKLDLSREN 337
>UniRef50_Q3E2I1 Cluster: Silent information regulator protein Sir2;
n=7; Bacteria|Rep: Silent information regulator protein
Sir2 - Chloroflexus aurantiacus J-10-fl
Length = 254
Score = 65.3 bits (152), Expect = 2e-09
Identities = 62/235 (26%), Positives = 98/235 (41%), Gaps = 34/235 (14%)
Query: 27 NDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFR-GPNGVWT-LEKE-------- 76
ND L+ +LA + ++H+ V TGAG+S +GIP FR G+W+ + E
Sbjct: 2 ND-LDDVITILATALSTARHVTVLTGAGVSAESGIPTFRDAQTGLWSHFDPEELASPAGF 60
Query: 77 GKKPTI--------NVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKF 128
+ P + V AQP H V+QNIDGLH ++G P+
Sbjct: 61 ARNPALVWRWYAERRVKACTAQPNPAHHALADLATLVPRLTLVTQNIDGLHQRAGSPQ-- 118
Query: 129 LAELHGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWE 188
+ ELHGN+ C + + T +P + C L V+ +
Sbjct: 119 VIELHGNIHRARCTV-------DGSIHTTWDYDEELPQCPN------CGALLRPDVVWFG 165
Query: 189 HSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPT 243
LP L A + D+ +GT+ + P+ +LP + G ++I NL+ T
Sbjct: 166 EYLPPGALEAAYAATLDCDVFCSIGTSGVVEPAASLPRIALSRGATVLILNLEQT 220
>UniRef50_Q7SCL4 Cluster: Putative uncharacterized protein NCU00523.1;
n=2; Pezizomycotina|Rep: Putative uncharacterized protein
NCU00523.1 - Neurospora crassa
Length = 1220
Score = 65.3 bits (152), Expect = 2e-09
Identities = 66/234 (28%), Positives = 96/234 (41%), Gaps = 35/234 (14%)
Query: 17 ILGVPEKFDSNDKLNQKCVLLAQLVKDSK--HIVVHTGAGISTSAGIPDFRGPN-GVWT- 72
+ VPE + + +A +K K +VV TGAGIST+AGIPDFR P G++
Sbjct: 848 VSAVPETTKPENLSERSLPAVADYIKSGKARKVVVLTGAGISTAAGIPDFRSPETGLYAN 907
Query: 73 ---LEKEGKKPTINVSF-----------------ADAQPTKTHMXXXXXXXXXXXXXXVS 112
LE E + ++ F PT +H+ +
Sbjct: 908 LAALELEEPEDVFSLPFFKENPKPFYVLAKDLYPGKFHPTISHVFISLLATKGLLYQLFT 967
Query: 113 QNIDGLHLKSGVPRKFLAELHGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVT 172
QNID L +GVP + E HG+ C CK + E V + + VP H
Sbjct: 968 QNIDCLERAAGVPADLIVEAHGSFASQRCIDCKTPYPDDKMREHVSR--AEVP----HC- 1020
Query: 173 GRPCRGRLYDGVLDWEHSLPENDLLMAEWH-SSIADLSICLGTTLQIVPSGNLP 225
C G + ++ + +LP L H + ADL + LGT+L + P LP
Sbjct: 1021 -EKCNGLVKPDIVFFHENLP--SLFFDRRHMAEEADLILVLGTSLTVHPFAGLP 1071
>UniRef50_UPI00004997CB Cluster: Sir2 family transcriptional
regulator; n=2; Entamoeba histolytica HM-1:IMSS|Rep:
Sir2 family transcriptional regulator - Entamoeba
histolytica HM-1:IMSS
Length = 346
Score = 64.9 bits (151), Expect = 3e-09
Identities = 66/216 (30%), Positives = 90/216 (41%), Gaps = 37/216 (17%)
Query: 31 NQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPN-GVW-TLE-------------- 74
N K L + ++VV GAGISTSAGIPDFR P G++ LE
Sbjct: 89 NAKGFGLFMKYRKPSNVVVMAGAGISTSAGIPDFRTPGTGLYDNLEAYNLPFPTAVFDIN 148
Query: 75 --KEGKKPTINVS------FADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPR 126
K KP ++ PT TH +QNIDGL ++SG P
Sbjct: 149 YFKSNPKPFYTIASELMPGLGKYFPTPTHYFLTYLNKLGYISMLFTQNIDGLEIQSGFPN 208
Query: 127 KFLAELHGNMFIDECNICKRQFVRSSPVETV--GKKCSGVPCAAHHVTGRPCRGRLYDGV 184
+ L HGN + C CK+ F +S ++ V GK C C + C+G + +
Sbjct: 209 EKLVMAHGNYYSGHCLKCKKSFKQSYFIDNVRDGKVCY---CDS-------CKGLVKPDI 258
Query: 185 LDWEHSLPENDLLMAEWHSSIADLSICLGTTLQIVP 220
+ + LP+ E DL I LGT+L P
Sbjct: 259 VFFGEGLPQQFFNNFE-KVEECDLLIVLGTSLLNTP 293
>UniRef50_Q5KDE0 Cluster: NAD-dependent histone deacetylase,
putative; n=2; Filobasidiella neoformans|Rep:
NAD-dependent histone deacetylase, putative -
Cryptococcus neoformans (Filobasidiella neoformans)
Length = 413
Score = 64.5 bits (150), Expect = 4e-09
Identities = 65/234 (27%), Positives = 99/234 (42%), Gaps = 31/234 (13%)
Query: 19 GVPEKFDSNDKLNQKCVLLAQLVK--DSKHIVVHTGAGISTSAGIPDFRGPN-GVW---- 71
G+ + S D LN A +K ++K ++ GAGISTSAGIPDFR P+ G++
Sbjct: 46 GIDDGALSGDDLNP-LRKAASFIKSGNAKDVIFLLGAGISTSAGIPDFRSPSTGLYHNLQ 104
Query: 72 TLEKEGKKPTINVSFADAQP-----------------TKTHMXXXXXXXXXXXXXXVSQN 114
LE + + F +P T TH +QN
Sbjct: 105 ALELPFPEAVFELGFFQRRPEPFWTLAKEIYPGRHFPTPTHYLLQLFNRHNLLKRVFTQN 164
Query: 115 IDGLHLKSGVPRKFLAELHGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVT-- 172
ID L +G+P + E HG+ C C+R+ R ++ +K V C A
Sbjct: 165 IDTLETLAGLPPHLIVEAHGSFATAHCLKCRREVDREEVLKAGVRKGEVVRCDATLKAMG 224
Query: 173 -GRPCRGRLYDGVLDWEHSLPENDL-LMAEWHSSIADLSICLGTTLQIVPSGNL 224
G+ C G + ++ + LP+ L+ E DL I +GT+LQ+ P +L
Sbjct: 225 KGKKCGGLVKPDIVFFGEGLPDRFFKLVPELRK--CDLLIVIGTSLQVQPFASL 276
>UniRef50_UPI0000519F58 Cluster: PREDICTED: similar to Sirt4
CG3187-PC, isoform C isoform 2; n=2; Endopterygota|Rep:
PREDICTED: similar to Sirt4 CG3187-PC, isoform C isoform
2 - Apis mellifera
Length = 302
Score = 63.3 bits (147), Expect = 1e-08
Identities = 67/272 (24%), Positives = 106/272 (38%), Gaps = 43/272 (15%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSFADA------- 89
L + +I V TGAGIST +GIPD+R GV + KP + F ++
Sbjct: 33 LKDFIDSHDNICVLTGAGISTESGIPDYRS-EGVGLYARSNHKPVLYKDFCNSDAIRRRY 91
Query: 90 --------------QPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGN 135
+P TH ++QN+D LH K+G K + ELHG
Sbjct: 92 WARNYIGWPRFSSIKPNNTHKILTKLENANKIRYIITQNVDNLHTKAG--SKKVIELHGT 149
Query: 136 MFIDECNICKRQ---------FVRSSPVETVGKKC----SGVPCAAHHVTG------RPC 176
F C C + F R +P TV + V V C
Sbjct: 150 AFRVMCLNCNERICRYYLQDIFDRINPNMTVTSQMIRPDGDVELTQEQVEEFKVPICEKC 209
Query: 177 RGRLYDGVLDWEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLV 236
G L ++ + ++P + +++ +D + +GTTL S + L+ G +
Sbjct: 210 DGILKPDIIFFGDNVPRKIVENIKYNIEHSDSLLIIGTTLTTFSSYRIALQANNIGKPIA 269
Query: 237 ICNLQPTKHDNKADLLINYYVDDVLEKVMDIL 268
I N+ T+ DN A + + +VL K+ +L
Sbjct: 270 ILNIGKTRVDNLAKIKVEGRCSNVLSKIYSML 301
>UniRef50_A1I9S7 Cluster: NAD-dependent deacetylase; n=1; Candidatus
Desulfococcus oleovorans Hxd3|Rep: NAD-dependent
deacetylase - Candidatus Desulfococcus oleovorans Hxd3
Length = 273
Score = 63.3 bits (147), Expect = 1e-08
Identities = 62/258 (24%), Positives = 106/258 (41%), Gaps = 33/258 (12%)
Query: 38 AQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW----------------TLEKEGKKPT 81
A+++ + V +GAG+S +GIP FR P GVW +LEK +K
Sbjct: 11 AKVLAGASRAAVFSGAGVSAESGIPTFRDPGGVWDRLNPAEVGDTQGLLASLEKNPEKLV 70
Query: 82 -----INVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNM 136
+ F A P H ++QNID LH ++G + + E+HGN
Sbjct: 71 AMFMELLAVFDAAIPNPGHRALFDLERMGILQAVITQNIDNLHQEAGNTQ--VIEMHGNG 128
Query: 137 FIDECNICK--RQFVRSSPVETVGKKCSGVP--CAAHHVTGRP----CRGRLYDGVLDWE 188
F C C+ R R + + V ++ S +P A P C + V+ +
Sbjct: 129 FRFRCLKCRSRRSHERHALIGRVKERLSTLPDFSPASIFAAMPDCDLCGSGMRPDVVMFG 188
Query: 189 HSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNK 248
++ E + A S D+ + LGT+ + P+ +P E G K+++ N
Sbjct: 189 ETVMEVENAFAAARS--CDVMLALGTSGVVTPAAQIPAEAKASGAKVIVINPNENGFARV 246
Query: 249 ADLLINYYVDDVLEKVMD 266
D+ I+ L ++++
Sbjct: 247 CDIYISMKTGQALPRIVE 264
>UniRef50_UPI00006CA40C Cluster: transcriptional regulator, Sir2
family protein; n=1; Tetrahymena thermophila SB210|Rep:
transcriptional regulator, Sir2 family protein -
Tetrahymena thermophila SB210
Length = 471
Score = 62.9 bits (146), Expect = 1e-08
Identities = 69/251 (27%), Positives = 107/251 (42%), Gaps = 35/251 (13%)
Query: 47 IVVHTGAGISTSAGIPDFRGP-NGVWTLEKEGKKP------TINVSFADAQP-------- 91
IV TGAGIS SAGIPDFR P +G+++ ++ K P IN QP
Sbjct: 214 IVFLTGAGISVSAGIPDFRTPGSGLYSQLQKYKLPYPEAIFEINYFKHHPQPFYTLCKEF 273
Query: 92 -------TKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNIC 144
T +H SQNIDGL L++G+P L + HG+ +C C
Sbjct: 274 SSCGSHFTSSHFFIAETNRRNRLLINFSQNIDGLELEAGLPESKLVQAHGHFRTAKCVNC 333
Query: 145 KRQFVRSSPVETV--GKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAEWH 202
K+ E V K C C G + ++ + SLP++ +
Sbjct: 334 KKVADIELFNEAVKNDKICYCKECE---------EGIVKPDIVFFGESLPQSFFQQID-S 383
Query: 203 SSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYYVDDVLE 262
+ ADL +GT+L++ P L ++ K +V+ N + + L + +DD +E
Sbjct: 384 LNKADLVFVMGTSLKVFPFAAL-VDLFKEDVPIVLINRENPGIKRRRFLFLEGEIDDNVE 442
Query: 263 KVMDILGIEIP 273
K+M + + P
Sbjct: 443 KIMKDISWDFP 453
>UniRef50_Q8Y015 Cluster: NAD-dependent deacetylase; n=11;
Bacteria|Rep: NAD-dependent deacetylase - Ralstonia
solanacearum (Pseudomonas solanacearum)
Length = 246
Score = 62.9 bits (146), Expect = 1e-08
Identities = 62/236 (26%), Positives = 104/236 (44%), Gaps = 41/236 (17%)
Query: 41 VKDSKHIVVHTGAGISTSAGIPDFRGP-NGVWT------LEKEG---KKPTI-------- 82
++ ++ ++V TGAG+S +G+P FR G+W L E + P +
Sbjct: 18 IEAAERVMVLTGAGVSAESGVPTFRDALTGLWARFNPEDLATEAAYREHPRMVWDWYQER 77
Query: 83 NVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMF----I 138
+ QP H+ V+QN+DGLH ++G + ELHGN+F +
Sbjct: 78 RARVSQVQPNPAHLAIAALATRKTVAL-VTQNVDGLHQRAGSVG--VIELHGNLFANKWL 134
Query: 139 DECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLM 198
D C C + P G+ CAA C L GV+ + LP
Sbjct: 135 DGCGKC--DVATAEP----GRPPR---CAA-------CGAMLRPGVVWFGERLPVVANYR 178
Query: 199 AEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLIN 254
AE ++ D+ + +GT+ + P+ LP +G ++++ N +P+ D ADL+I+
Sbjct: 179 AEEAANTCDVCLVVGTSGMVYPAAGLPGLAKDHGARVIVVNPEPSVLDETADLVIH 234
>UniRef50_Q54QE6 Cluster: Zn finger-containing protein; n=5;
Eukaryota|Rep: Zn finger-containing protein -
Dictyostelium discoideum AX4
Length = 512
Score = 62.1 bits (144), Expect = 2e-08
Identities = 57/202 (28%), Positives = 88/202 (43%), Gaps = 27/202 (13%)
Query: 45 KHIVVHTGAGISTSAGIPDFRGPN----------------GVWTLE--KEGKKPTINVS- 85
K+I+V TGAGIS +AGIPDFR P ++ +E K+ KP +S
Sbjct: 251 KNIIVMTGAGISVAAGIPDFRSPKTGLYEKLDKYDLPYREAIFDIEYFKKNPKPFYVLSK 310
Query: 86 --FADA-QPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECN 142
F + PT H +QNID L +G+P L E HG+ C
Sbjct: 311 ELFPGSFNPTTVHYFIKLLSDKGLLLRNFTQNIDTLERIAGIPANKLVEAHGSFATSHCV 370
Query: 143 ICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAEWH 202
CK+++ E + K +P +G C+G + ++ + SLP A
Sbjct: 371 SCKKEYSTEYVKERIFK--DELP-ECTETSG--CKGIVKPDIVFFGESLPSRFNDCARED 425
Query: 203 SSIADLSICLGTTLQIVPSGNL 224
+ DL + +GT+L++ P +L
Sbjct: 426 FTKCDLLLVIGTSLKVHPFASL 447
>UniRef50_Q8REC3 Cluster: NAD-dependent deacetylase; n=3;
Fusobacterium nucleatum|Rep: NAD-dependent deacetylase -
Fusobacterium nucleatum subsp. nucleatum
Length = 252
Score = 62.1 bits (144), Expect = 2e-08
Identities = 70/260 (26%), Positives = 118/260 (45%), Gaps = 45/260 (17%)
Query: 27 NDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW-TLEKEGKKP----- 80
+ K ++K + L +++K++K++V GAG ST +G+ DFRG +G++ TL K+ +P
Sbjct: 2 DSKRDEKILELVKILKNTKYLVFFGGAGTSTDSGVKDFRGKDGLYKTLYKDKYRPEEVLS 61
Query: 81 --------TINVSFADAQ-------PTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVP 125
I + + + + P K HM ++QNID LH SG
Sbjct: 62 SDFFYSHRDIFMKYVEKELNIKGLKPNKGHMALVELEKIGILKAVITQNIDDLHQVSG-- 119
Query: 126 RKFLAELHGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVL 185
K + ELHG++ C C + R+ E C GV RP V
Sbjct: 120 NKNVLELHGSLKRWYCLSCGKTADRNFSCE-----CGGVV--------RP-------DVT 159
Query: 186 DWEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKH 245
+ +L ++ + A + AD I GT+L + P+ L + G L+I N T++
Sbjct: 160 LYGENLNQSVVNEAIYQLEQADTLIVAGTSLTVYPAAYY-LRYFR-GKNLIIINDMDTQY 217
Query: 246 DNKADLLINYYVDDVLEKVM 265
D +A L+I V+++V+
Sbjct: 218 DGEASLVIKDNFSYVMDRVV 237
>UniRef50_UPI0000E49AD8 Cluster: PREDICTED: similar to NAD-dependent
deacetylase sirtuin 2 homolog; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to NAD-dependent
deacetylase sirtuin 2 homolog - Strongylocentrotus
purpuratus
Length = 400
Score = 61.7 bits (143), Expect = 3e-08
Identities = 62/213 (29%), Positives = 92/213 (43%), Gaps = 32/213 (15%)
Query: 37 LAQLVKDSK--HIVVHTGAGISTSAGIPDFRGPN-GVW-TLEK----------------E 76
+A +K+ K ++V +GAGISTSAGIPDFR P G++ L+K +
Sbjct: 64 IADFIKEGKCKKVIVMSGAGISTSAGIPDFRTPGTGLYDNLQKYNLPNPQAIFEIGFFKQ 123
Query: 77 GKKPTINVS---FADA-QPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAEL 132
+P +S F A PT +H +QNIDGL +GVP + + E
Sbjct: 124 NPEPFFTLSKELFPGAFYPTPSHFFIHLLHEKGILLRHYTQNIDGLDRMAGVPDELIMEA 183
Query: 133 HGNMFIDECNICKRQFVRSSPVETVGKKCSGVP-CAAHHVTGRPCRGRLYDGVLDWEHSL 191
HG+ C C + S E + +P CA + T G + V+ + SL
Sbjct: 184 HGSFHTGHCLNCNEMYTEESMREKI--MADLIPRCAKCNET-----GVVKPDVVFFGESL 236
Query: 192 PENDLLMAEWHSSIADLSICLGTTLQIVPSGNL 224
P + DL I +GT+L + P +L
Sbjct: 237 PPRFPTLVSEDFPQCDLLIVMGTSLVVQPFASL 269
>UniRef50_Q8F3Z6 Cluster: NAD-dependent deacetylase; n=4;
Leptospira|Rep: NAD-dependent deacetylase - Leptospira
interrogans
Length = 246
Score = 61.7 bits (143), Expect = 3e-08
Identities = 61/237 (25%), Positives = 99/237 (41%), Gaps = 32/237 (13%)
Query: 51 TGAGISTSAGIPDFRGPNGVW---------TLEKEGKKPTI---------NVSFADAQPT 92
+GAGIS +GIP FRG G+W T + K P + N+ +P
Sbjct: 19 SGAGISAESGIPTFRGSEGLWKNFRAEDLATPQAFSKNPKLVWEWYLWRRNI-IETKRPN 77
Query: 93 KTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNICKRQFVRSS 152
H ++QN+DGLH ++G K L E+HGN+FI+ C C ++
Sbjct: 78 PGHFALVELERIHPDFFLITQNVDGLHSQAG--SKKLTEIHGNIFINRCISCGQE----- 130
Query: 153 PVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAEWHSSIADLSICL 212
ET+ + + +P + C L GV+ + S + L ++ DL + L
Sbjct: 131 SKETISENTTPLPPQCQN-----CNSFLRPGVVWFGESYDDFKLNLSIQRMKHTDLLLVL 185
Query: 213 GTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYYVDDVL-EKVMDIL 268
GT+ + L G L+ N + + + DL + +VL E + +IL
Sbjct: 186 GTSGSVSMPVYLAQIAKDSGALLIEINPERSSFSSSVDLFLQGKTGEVLPELIREIL 242
>UniRef50_Q5V4Q5 Cluster: NAD-dependent deacetylase; n=2;
Halobacteriaceae|Rep: NAD-dependent deacetylase -
Haloarcula marismortui (Halobacterium marismortui)
Length = 260
Score = 61.7 bits (143), Expect = 3e-08
Identities = 59/251 (23%), Positives = 105/251 (41%), Gaps = 28/251 (11%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGK--KPTINVSFA------- 87
+A+ ++ ++ V TGAG+ST++GIP FRG +G+W + ++ A
Sbjct: 19 VAEALRTAETAVALTGAGVSTASGIPSFRGDDGIWERHDPADFHRRRLDADPAGFWADRL 78
Query: 88 ----------DAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMF 137
D +P H ++QNIDGLH +G R + ELHG
Sbjct: 79 SLREAIYGDIDPEPNAAHEALAALEADGHLDAVLTQNIDGLHDAAGTDR--VVELHGTHR 136
Query: 138 IDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLL 197
C+ C + E + S +P C G V+ + +P+ +
Sbjct: 137 RVVCDDCGHRRDAEVVFEQAAES-SDLPPRCD------CGGVYRPDVVLFGEPMPDVAMN 189
Query: 198 MAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYYV 257
A+ + +D+ + +G++L + P+ LP + LV+ N + T D A ++ V
Sbjct: 190 EAQRLARDSDVFLAVGSSLSVQPASLLPKIAAEGDSTLVVVNYEETPRDASAAHVLRADV 249
Query: 258 DDVLEKVMDIL 268
VL +++ L
Sbjct: 250 TQVLPAIVERL 260
>UniRef50_Q9NTG7 Cluster: NAD-dependent deacetylase sirtuin-3,
mitochondrial precursor; n=22; Euteleostomi|Rep:
NAD-dependent deacetylase sirtuin-3, mitochondrial
precursor - Homo sapiens (Human)
Length = 399
Score = 61.3 bits (142), Expect = 4e-08
Identities = 63/224 (28%), Positives = 95/224 (42%), Gaps = 35/224 (15%)
Query: 26 SNDKLNQKCVLLAQLVKDS--KHIVVHTGAGISTSAGIPDFRGP-NGVWTLEKEGKKPTI 82
S+DK +A+L++ + +VV GAGIST +GIPDFR P +G+++ ++ P
Sbjct: 117 SSDKGKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYP 176
Query: 83 NVSF---------------------ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLK 121
F + +P TH +QNIDGL
Sbjct: 177 EAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERV 236
Query: 122 SGVPRKFLAELHGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRP-CRGRL 180
SG+P L E HG C +C+R F P E + A V P C G +
Sbjct: 237 SGIPASKLVEAHGTFASATCTVCQRPF----PGEDI-----RADVMADRVPRCPVCTGVV 287
Query: 181 YDGVLDWEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNL 224
++ + LP+ LL +ADL + LGT+L++ P +L
Sbjct: 288 KPDIVFFGEPLPQRFLLHVV-DFPMADLLLILGTSLEVEPFASL 330
>UniRef50_Q4WFZ3 Cluster: SIR2 family histone deacetylase, putative;
n=4; Trichocomaceae|Rep: SIR2 family histone
deacetylase, putative - Aspergillus fumigatus (Sartorya
fumigata)
Length = 403
Score = 60.9 bits (141), Expect = 5e-08
Identities = 73/282 (25%), Positives = 108/282 (38%), Gaps = 34/282 (12%)
Query: 37 LAQLVKDSK--HIVVHTGAGISTSAGIPDFRGPN-GVWTLEKEGKKPTINVSF------- 86
+A L+K + IVV GAGIST+AGIPDFR P G++ K P F
Sbjct: 83 IANLIKSGQVHKIVVLVGAGISTAAGIPDFRSPETGIYDRLKPLHLPYPEAIFHINYFRH 142
Query: 87 --------------ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAEL 132
+PT TH +QNIDGL G+P +
Sbjct: 143 TPEPFYAIARARHPRSLKPTITHAFLALLEKKGLLHFVFTQNIDGLERDVGIPEDKILNA 202
Query: 133 HGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLP 192
HG+ C CK + + + VP + C G + ++ + LP
Sbjct: 203 HGSWRTQRCWKCKTPYPDDLMKQAI--STGTVP----YCQVPDCGGAVKPDIVFFGQPLP 256
Query: 193 ENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNK--AD 250
+ E S AD+ + +GT+L++ P LP + G V+ N + K D
Sbjct: 257 A-EFDEKEKEVSEADMMLVMGTSLKVAPCSRLP-RLAREGIPRVLVNREKVGDFGKRAED 314
Query: 251 LLINYYVDDVLEKVMDILGIEIPSYNESENPMKFAETAIIDW 292
+ I DD + K+ D LG + + + E A DW
Sbjct: 315 VSILGDCDDGVRKLADALGWTAEMESLWKKAIAAKEAAQEDW 356
>UniRef50_Q607X6 Cluster: NAD-dependent deacetylase; n=1;
Methylococcus capsulatus|Rep: NAD-dependent deacetylase
- Methylococcus capsulatus
Length = 255
Score = 60.9 bits (141), Expect = 5e-08
Identities = 70/253 (27%), Positives = 102/253 (40%), Gaps = 33/253 (13%)
Query: 36 LLAQLVKDSKHIVVHTGAGISTSAGIPDFRGP-NGVW------TLEK-EG--KKPTINVS 85
LLA L +D++HI V TGAG+S +GIP FR G W TL EG P +
Sbjct: 7 LLASL-RDARHIAVFTGAGVSAESGIPTFRDALTGFWENYDASTLASPEGFAADPALVWG 65
Query: 86 FAD--------AQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMF 137
+ + A+P H ++QN+D LH ++G LHG++
Sbjct: 66 WYEWRRTRVLRAEPNPAHYAIAALAADCPRLTLITQNVDDLHERAGSADPI--RLHGSLH 123
Query: 138 IDECNICKRQF--VRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPEND 195
C+ C+ + P E G + P A G P R GV+ +LP+
Sbjct: 124 HPRCSACEAPYRLPPGIPDEPEGGRRVDPPRCAR--CGAPVR----PGVVWLGENLPQAA 177
Query: 196 LLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINY 255
A + DL +GT+ + P+ LP + G +V N T D A Y
Sbjct: 178 WDAARQAAEDCDLMFSIGTSALVWPAAQLPALVARRGATVVQVNPAETALDGHA----GY 233
Query: 256 YVDDVLEKVMDIL 268
+ KVM +L
Sbjct: 234 NLRGAAGKVMPLL 246
>UniRef50_Q1D737 Cluster: NAD-dependent deacetylase; n=1; Myxococcus
xanthus DK 1622|Rep: NAD-dependent deacetylase -
Myxococcus xanthus (strain DK 1622)
Length = 245
Score = 60.5 bits (140), Expect = 7e-08
Identities = 63/229 (27%), Positives = 95/229 (41%), Gaps = 27/229 (11%)
Query: 40 LVKDSKH-IVVHTGAGISTSAGIPDFRGPNGVW-------TLEKEG--KKPTINVSF--- 86
L+ DS ++V TGAG+S +G+P FRG +G+W EG K P + F
Sbjct: 4 LILDSNTWLLVLTGAGVSAESGVPTFRGMSGLWEDQPVEAVASPEGFRKDPALVWRFYSE 63
Query: 87 -----ADAQPTKTHMXXXXXXXXXXXXXXVS-QNIDGLHLKSGVPRKFLAELHGNMFIDE 140
A P H ++ QN+DGLH ++G R + E+HGN+F
Sbjct: 64 RRKAAAAVHPNPGHEALVAWERHLGDRFLLATQNVDGLHTRAGSQR--VVEMHGNLFKTR 121
Query: 141 CNICKRQFVRSSPVETVGKKCSGVP-CAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMA 199
C+ C R + V G VP C A RP + LD D +
Sbjct: 122 CSRCGRPPFEDATVYPAG----AVPECDACGKLLRP-HIVWFGEYLDPADIQRIEDFSLR 176
Query: 200 EWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNK 248
S + + GT+ + P+ + + K GGK + NL P ++ N+
Sbjct: 177 AATSGGRFVFLAAGTSGAVYPAAGIVDQVRKAGGKTWLVNLDPAENSNR 225
>UniRef50_Q3A6W7 Cluster: NAD-dependent protein deacetylases, SIR2
family; n=2; Pelobacter|Rep: NAD-dependent protein
deacetylases, SIR2 family - Pelobacter carbinolicus
(strain DSM 2380 / Gra Bd 1)
Length = 278
Score = 60.1 bits (139), Expect = 9e-08
Identities = 57/215 (26%), Positives = 97/215 (45%), Gaps = 35/215 (16%)
Query: 38 AQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSFADAQ------- 90
A +++ S+ +V +GAGIST+AGIPDFRGP G++ + + ++ + +
Sbjct: 26 ADMIRRSRCVVTLSGAGISTAAGIPDFRGPQGLYVTRRYDPEKVFDIDWFHREPRYFYEF 85
Query: 91 ------------PTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFI 138
PT TH ++QNID LH +G RK + +LHG+
Sbjct: 86 TRDFVSTVKAIRPTFTHRFLAGLEKAGGLAGLITQNIDMLHQLAG-SRKVI-DLHGSYRS 143
Query: 139 DECNICKRQFVRSSPV--ETVGKKCSGVP---CAAHHVTGRPCRGRLYDGVLDWEHSLPE 193
+C C + + S E S P C+A + +P ++ G + H+
Sbjct: 144 AQCLFCGKSYEALSYTWWERAMSTSSKPPLAYCSACNSVLKP--DIVFFG--EMVHAFEA 199
Query: 194 NDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLET 228
+ L+A+ DL + LG++L++ P+ LP T
Sbjct: 200 AEQLIAQ-----CDLLLVLGSSLKVTPASLLPYHT 229
>UniRef50_A0LG97 Cluster: Silent information regulator protein Sir2;
n=1; Syntrophobacter fumaroxidans MPOB|Rep: Silent
information regulator protein Sir2 - Syntrophobacter
fumaroxidans (strain DSM 10017 / MPOB)
Length = 248
Score = 60.1 bits (139), Expect = 9e-08
Identities = 55/219 (25%), Positives = 90/219 (41%), Gaps = 31/219 (14%)
Query: 38 AQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGK---------KPT------- 81
A+L+ S++ VV TGAGIS +GIPDFR +G+W+ + P
Sbjct: 8 AELLLRSRYTVVLTGAGISVESGIPDFRSKDGLWSKYDPAEYGYIGSFRANPAKVWTMLT 67
Query: 82 -INVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDE 140
++ A+P H+ V+QNID LH ++G K + E HG+
Sbjct: 68 EMDAVLRQARPNFAHLALADLEKRGIVKELVTQNIDSLHQRAG--SKNVIEFHGHNRSLR 125
Query: 141 CNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAE 200
C+ C++ + R E+V CA C L ++ + +P A
Sbjct: 126 CDRCQKVYAR----ESVSLATLPPACA--------CGNALRPEIVFFGEDIPPQAYRSAL 173
Query: 201 WHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICN 239
+ D + +GT+ + P+ LPL G ++ N
Sbjct: 174 NAAQKCDFMMIVGTSASVAPASQLPLVAKSRGAFILEIN 212
>UniRef50_Q8R104 Cluster: NAD-dependent deacetylase sirtuin-3; n=8;
Deuterostomia|Rep: NAD-dependent deacetylase sirtuin-3 -
Mus musculus (Mouse)
Length = 257
Score = 60.1 bits (139), Expect = 9e-08
Identities = 61/210 (29%), Positives = 89/210 (42%), Gaps = 35/210 (16%)
Query: 52 GAGISTSAGIPDFRGP-NGVWTLEKEGKKPTINVSF---------------------ADA 89
GAGIST +GIPDFR P +G+++ ++ P F
Sbjct: 3 GAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAIFELGFFFHNPKPFFMLAKELYPGHY 62
Query: 90 QPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNICKRQFV 149
+P TH +QNIDGL SG+P L E HG C +C+R F
Sbjct: 63 RPNVTHYFLRLLHDKELLLRLYTQNIDGLERASGIPASKLVEAHGTFVTATCTVCRRSF- 121
Query: 150 RSSPVETVGKKCSGVPCAAHHVTGRP-CRGRLYDGVLDWEHSLPENDLL-MAEWHSSIAD 207
P E + A V P C G + ++ + LP LL MA++ ++AD
Sbjct: 122 ---PGEDI-----WADVMADRVPRCPVCTGVVKPDIVFFGEQLPARFLLHMADF--ALAD 171
Query: 208 LSICLGTTLQIVPSGNLPLETIKYGGKLVI 237
L + LGT+L++ P +L K +L+I
Sbjct: 172 LLLILGTSLEVEPFASLSEAVQKSVPRLLI 201
>UniRef50_A1ZPG8 Cluster: NAD-dependent deacetylase; n=1;
Microscilla marina ATCC 23134|Rep: NAD-dependent
deacetylase - Microscilla marina ATCC 23134
Length = 278
Score = 59.7 bits (138), Expect = 1e-07
Identities = 41/130 (31%), Positives = 58/130 (44%), Gaps = 22/130 (16%)
Query: 35 VLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKP----TI-------- 82
+L AQ + K I TGAGIS +G+P +RG +G+W KP T+
Sbjct: 10 LLCAQALAQDKLITFLTGAGISAESGVPTYRGTDGIWVEGSRNYKPEEFATLRFFKENPA 69
Query: 83 ---------NVSFADAQPTKTHMXXXXXXXXX-XXXXXVSQNIDGLHLKSGVPRKFLAEL 132
VSF D QP H+ ++QNID LH+K+G + + E+
Sbjct: 70 EVWKFVLYRKVSFRDLQPNAGHLALASTEVLLPNNFRLITQNIDRLHIKAGNTQAKVLEI 129
Query: 133 HGNMFIDECN 142
HGNM C+
Sbjct: 130 HGNMETVRCS 139
>UniRef50_A0C2R2 Cluster: Chromosome undetermined scaffold_145,
whole genome shotgun sequence; n=1; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_145,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 258
Score = 59.7 bits (138), Expect = 1e-07
Identities = 66/253 (26%), Positives = 105/253 (41%), Gaps = 41/253 (16%)
Query: 42 KDSKHIVVHTGAGISTSAGIPDFRG----------------PNGVWTLEKEGKKPTINVS 85
K+ K I + GAGIS +AG+ D+R P V+ + K P++ S
Sbjct: 15 KEFKKITIAAGAGISVAAGLSDYRSKDTGLYDQLKKFNLSNPEQVYDINVFRKNPSLYYS 74
Query: 86 FA--------DAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMF 137
+ D QPT H +QNIDGL L +GV + ++HG+
Sbjct: 75 VSKEFGTHNLDLQPTFAHQFIYHLDRNDQLLNCFTQNIDGLELVAGVRESKVIQVHGHRR 134
Query: 138 IDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLL 197
C CK+ + + + V K + C C G + V+ + SLP+
Sbjct: 135 TASCIDCKKTYCVKTFYQNVDKS-EIMKCT-------DCNGLIKPDVVFFGQSLPQLYFE 186
Query: 198 MAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKH-----DNKADLL 252
S++DL I +GT+LQ+ P N+ + I +V+ N + +NK LL
Sbjct: 187 KLP-EISLSDLVIIMGTSLQVQPFSNM-IYRINENVPIVLINKETNLRRLDPINNK--LL 242
Query: 253 INYYVDDVLEKVM 265
I V D++ +M
Sbjct: 243 IKGDVQDIISSIM 255
>UniRef50_A1FG80 Cluster: Silent information regulator protein Sir2;
n=3; Pseudomonas|Rep: Silent information regulator
protein Sir2 - Pseudomonas putida W619
Length = 252
Score = 59.3 bits (137), Expect = 2e-07
Identities = 52/220 (23%), Positives = 91/220 (41%), Gaps = 24/220 (10%)
Query: 38 AQLVKDSKHIVVHTGAGISTSAGIPDFRGP-NGVW---------TLEKEGKKPTI----- 82
A+ ++ ++HI+V TGAG+S +GIP FR G+W T + + P +
Sbjct: 8 AEALRSAQHIMVFTGAGVSAGSGIPTFRDELTGLWERQDPQRLETAQAFRENPALVWGWY 67
Query: 83 ---NVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFID 139
A+P H V+QNID LH ++G + + LHG++
Sbjct: 68 LWRRQQVMQAKPNAAHQAIHRLSGSGRSVTVVTQNIDDLHERAG--NQEVLHLHGSLMRP 125
Query: 140 ECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMA 199
+C C R V + + + + R C GRL ++ + LP A
Sbjct: 126 KCFACHRFVVEPLVFPIIPAEGALI----EPPRCRRCNGRLRPAIVWFGEYLPPGVWKAA 181
Query: 200 EWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICN 239
+ D+ + +GT+ + P+ +LP + G ++ N
Sbjct: 182 SQAARQCDILLSIGTSGVVRPAADLPDIALASGAVVIHVN 221
>UniRef50_A6RXY5 Cluster: Putative uncharacterized protein; n=2;
Pezizomycotina|Rep: Putative uncharacterized protein -
Botryotinia fuckeliana B05.10
Length = 446
Score = 59.3 bits (137), Expect = 2e-07
Identities = 59/204 (28%), Positives = 83/204 (40%), Gaps = 29/204 (14%)
Query: 44 SKHIVVHTGAGISTSAGIPDFRGP-NGVWTLEKEGKKPTINVSF---------------- 86
+K+IVV TGAGISTSAGIPDFR P G++ E P F
Sbjct: 36 AKNIVVMTGAGISTSAGIPDFRSPETGIYANLAELNLPYAEAVFDIDFFRENPAPFYVLA 95
Query: 87 -----ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDEC 141
PT +H +QNID L ++GV + + E HG+ C
Sbjct: 96 KELYPGQFYPTVSHAFVALIEKKGLLRMLFTQNIDCLERRAGVSSEKVIEAHGSFATQRC 155
Query: 142 NICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAEW 201
CK ++ P + + K A V C G + ++ + LPE +
Sbjct: 156 IDCKTEY----PDDMMKKAIEDGDPATCLVP--QCGGLVKPDIVFFGEQLPE-AFHANKM 208
Query: 202 HSSIADLSICLGTTLQIVPSGNLP 225
+ ADL I +GT+L + P LP
Sbjct: 209 IPATADLVIVMGTSLSVQPFATLP 232
>UniRef50_Q8G465 Cluster: Sir2-type regulatory protein; n=2;
Bifidobacterium longum|Rep: Sir2-type regulatory protein
- Bifidobacterium longum
Length = 216
Score = 58.8 bits (136), Expect = 2e-07
Identities = 40/180 (22%), Positives = 79/180 (43%), Gaps = 1/180 (0%)
Query: 88 DAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNICKRQ 147
+AQP H +QN D LH K+G + LHG + C C ++
Sbjct: 30 NAQPGTAHKALVKLEQAGMLTLLATQNFDALHEKAGNSDNVIVNLHGTIGTSHCMKCHQE 89
Query: 148 FVRSSPVETVGKKCSGVPCAAHHVTG-RPCRGRLYDGVLDWEHSLPENDLLMAEWHSSIA 206
+ + + + ++ G PC G + V+ + +LP+ + + ++ A
Sbjct: 90 YATADIMARLDEEPDPHCHRKLKYRGDMPCNGIIKTDVVYFGEALPDGAMEKSYSLATKA 149
Query: 207 DLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYYVDDVLEKVMD 266
D +G+TL++ P+ ++ + G + I N+ T++D+ A LI+ + L K++D
Sbjct: 150 DELWVIGSTLEVYPAASIVPVAAQAGVPITIMNMGHTQYDHLASRLIHEDIAVALPKLVD 209
>UniRef50_Q54GV7 Cluster: NAD(+)-dependent deacetylase, silent
information regulator protein (Sir2) family protein;
n=1; Dictyostelium discoideum AX4|Rep: NAD(+)-dependent
deacetylase, silent information regulator protein (Sir2)
family protein - Dictyostelium discoideum AX4
Length = 542
Score = 58.8 bits (136), Expect = 2e-07
Identities = 68/254 (26%), Positives = 109/254 (42%), Gaps = 32/254 (12%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW-TLEKEGKKPTINVSF--------- 86
+ QL + SK+IV+ TGAG+S S GIPDFR GV+ T+EK+ P F
Sbjct: 293 VCQLFESSKNIVIITGAGVSVSCGIPDFRSKGGVYETIEKKYNLPRPESLFDIHYLRANP 352
Query: 87 ------------ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHG 134
+ +P+ TH +QNID L +G+ R+ L HG
Sbjct: 353 LPFFEFAKEIFPGNHKPSPTHSFIKLLDEKGKLLRNYTQNIDTLEHVAGIDREKLVNCHG 412
Query: 135 NMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPEN 194
+ C CK ++ +T+ K +P G + + ++ + +LP+
Sbjct: 413 SFSTATCITCKLTVDGTTIRDTIMK--MEIPLCQQCNDG---QSFMKPDIVFFGENLPDR 467
Query: 195 -DLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICN---LQPTKHDNKAD 250
D + + I DL I +G++LQ+ P LP K +++I QP + D
Sbjct: 468 FDQCVLKDVKDI-DLLIVMGSSLQVQPVSLLPDIVDKQIPQILINRELVAQPHEFDYVYL 526
Query: 251 LLINYYVDDVLEKV 264
+ +V D+L KV
Sbjct: 527 GDCDQFVQDLLNKV 540
>UniRef50_A7EC18 Cluster: Putative uncharacterized protein; n=1;
Sclerotinia sclerotiorum 1980|Rep: Putative
uncharacterized protein - Sclerotinia sclerotiorum 1980
Length = 446
Score = 58.4 bits (135), Expect = 3e-07
Identities = 60/213 (28%), Positives = 92/213 (43%), Gaps = 31/213 (14%)
Query: 37 LAQLVKD--SKHIVVHTGAGISTSAGIPDFRGP-NGVWT----LEKEGKKPTINVSF--- 86
+A+ +K+ +K+IVV TGAGISTSAGIPDFR P G++ L+ + ++ F
Sbjct: 27 VAEFIKNGQAKNIVVLTGAGISTSAGIPDFRSPETGIYANLAELDLPYAEAVFDIDFFRE 86
Query: 87 --------------ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAEL 132
PT +H +QNID L ++GV + + E
Sbjct: 87 NPAPFYVLAKELYPGQFYPTISHAFVALIEKKGLLRMLFTQNIDCLERRAGVSSEKVIEA 146
Query: 133 HGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLP 192
HG+ C CK ++ P + + K A V C G + ++ + LP
Sbjct: 147 HGSFATQRCIDCKTEY----PDDMMKKAIQEGDPATCLVP--QCGGLVKPDIVFFGEQLP 200
Query: 193 ENDLLMAEWHSSIADLSICLGTTLQIVPSGNLP 225
E + + ADL I +GT+L + P LP
Sbjct: 201 E-AFHSHKMIPATADLIIVMGTSLSVQPFAMLP 232
>UniRef50_Q07FY7 Cluster: Sirtuin (Silent mating type information
regulation 2 homolog) 3; n=3; Xenopus|Rep: Sirtuin
(Silent mating type information regulation 2 homolog) 3
- Xenopus tropicalis (Western clawed frog) (Silurana
tropicalis)
Length = 401
Score = 57.6 bits (133), Expect = 5e-07
Identities = 55/207 (26%), Positives = 91/207 (43%), Gaps = 32/207 (15%)
Query: 46 HIVVHTGAGISTSAGIPDFRGP-NGVW-TLEKEG---KKPTINVSF-------------- 86
+I+V GAGIST++GIPDFR P +G++ L+K + ++++
Sbjct: 128 NIIVMAGAGISTASGIPDFRTPGSGLYDNLQKYDIPYPEAIFDINYFVCNPNPFFHLAKE 187
Query: 87 ---ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNI 143
+P H +QNIDGL +G+P + + E+HG F C++
Sbjct: 188 LFPGKYKPNLVHYFIKLLHDKGLLLRCYTQNIDGLERLAGIPVEKIVEVHGTFFSASCSL 247
Query: 144 CKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAEWHS 203
C F + E + PC + C G + ++ + LP+ A
Sbjct: 248 CYTPFPANEAKELIFD--GNPPCC------KFCAGPVKPDIVFFGEDLPQT-FTQAYQDF 298
Query: 204 SIADLSICLGTTLQIVPSGNLPLETIK 230
ADL I +GT+L+I P +L + T+K
Sbjct: 299 PKADLLIIMGTSLKIEPFASL-VNTVK 324
>UniRef50_Q25337 Cluster: NAD-dependent deacetylase SIR2 homolog;
n=6; Leishmania|Rep: NAD-dependent deacetylase SIR2
homolog - Leishmania major
Length = 381
Score = 57.6 bits (133), Expect = 5e-07
Identities = 59/209 (28%), Positives = 85/209 (40%), Gaps = 34/209 (16%)
Query: 42 KDSKHIVVHTGAGISTSAGIPDFRG----------------PNGVWTLEKEGKKPTINVS 85
KD + I+V GAG S +AGIPDFR P ++L +KP I S
Sbjct: 29 KDVRRILVLVGAGASVAAGIPDFRSSDTGIYAKLGKYNLDDPTDAFSLTLLREKPEIFYS 88
Query: 86 FADA--------QPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMF 137
A QPT H +QNIDGL +GV + L E HG+
Sbjct: 89 IARELNLWPGHFQPTAVHHFIRLLQDEGRLLRCCTQNIDGLEKAAGVSPELLVEAHGSFA 148
Query: 138 IDECNICKRQF-VRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDL 196
C C F + + +E + S C+ C G + V+ + +LP+
Sbjct: 149 AAACIECHTPFSIEQNYLEAMSGTVS--RCST-------CGGIVKPNVVFFGENLPDAFF 199
Query: 197 LMAEWHSSIADLSICLGTTLQIVPSGNLP 225
+ IA+L I +GT++Q+ P LP
Sbjct: 200 DALHHDAPIAELVIIIGTSMQVHPFALLP 228
>UniRef50_A7SX90 Cluster: Predicted protein; n=3; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 306
Score = 56.8 bits (131), Expect = 8e-07
Identities = 56/232 (24%), Positives = 95/232 (40%), Gaps = 28/232 (12%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW-------------------TLEKEG 77
+ +L+K K+I+V TGAG+S S GIPDFR +G++ T +
Sbjct: 62 VVRLIKKCKNIIVLTGAGVSVSCGIPDFRSRDGIYAKLSVEYPDLPDPQAMFDITYFNQN 121
Query: 78 KKPTI----NVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELH 133
KP + +P+ H SQNID L +G+ R + + H
Sbjct: 122 PKPFFKFAKEIYPGQFKPSLCHRFIHQLEEHGHLLRNYSQNIDTLEQVAGITR--VIQCH 179
Query: 134 GNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPE 193
G+ C CK + + E + +K +P + + ++ + SLP
Sbjct: 180 GSFSTASCMRCKHKVPCEAIKEDIFRK--NIPVCSTCSPDEEFPSIMKPDIVFFGESLPS 237
Query: 194 NDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKH 245
N S+ ADL I +G++L++ P +P I ++ N +P +H
Sbjct: 238 NFYTHLGDDSNKADLLIVIGSSLKVRPVALIP-SHISPEVPQILINREPLRH 288
>UniRef50_Q5KZE8 Cluster: NAD-dependent deacetylase 2; n=3;
Bacteria|Rep: NAD-dependent deacetylase 2 - Geobacillus
kaustophilus
Length = 247
Score = 56.4 bits (130), Expect = 1e-06
Identities = 60/239 (25%), Positives = 97/239 (40%), Gaps = 38/239 (15%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKE---------GKKPTINV--- 84
LAQ +K++ I V TGAG+ST +GIPDFR NG++ E KK ++
Sbjct: 7 LAQWIKEANTIAVLTGAGMSTESGIPDFRSENGLYAQEDNVEYYLSEYYYKKDPVDFWRR 66
Query: 85 --------SFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNM 136
P H ++QNIDGLH K+G + ELHG +
Sbjct: 67 FKRMFSLKMMGGFAPNDGHRFLRWLEEMGKTVTILTQNIDGLHTKAGSTN--VIELHGTL 124
Query: 137 FIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDL 196
C C ++ S +C C+ + V+ + +P +
Sbjct: 125 QTATCPSCGNKYDLSFINRHEVPRC------------EKCQTIVKPDVVLFGGLVPRMEE 172
Query: 197 LMAEWHSSIADLSICLGTTLQIVPSGNLP--LETIKYGGKLVICNLQPTKHDNKADLLI 253
A ++ +DL + +GT+L++ P +P + + V+ N T+ D DL+I
Sbjct: 173 AFAA--AAASDLLLAMGTSLEVAPVNQIPFYVAAESPATRKVLINKTATRMDGMFDLVI 229
>UniRef50_Q4S7H2 Cluster: Chromosome 13 SCAF14715, whole genome
shotgun sequence; n=6; Clupeocephala|Rep: Chromosome 13
SCAF14715, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 327
Score = 55.6 bits (128), Expect = 2e-06
Identities = 57/206 (27%), Positives = 85/206 (41%), Gaps = 33/206 (16%)
Query: 37 LAQLVK--DSKHIVVHTGAGISTSAGIPDFRGPN----------------GVWTLEKEGK 78
+A+LVK +++VV GAGIST++GIPDFR P V++++
Sbjct: 39 VARLVKLGRCRNVVVVAGAGISTASGIPDFRTPGTGLYANLEQYKLPYPEAVFSIDYFSD 98
Query: 79 KPTINVSFADA------QPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAEL 132
P S A A +P H +QNIDGL G+P L E
Sbjct: 99 DPLPFFSLAKALYPGHHRPNYIHYFVRMLHHKGLLLRVYTQNIDGLERLCGIPEDKLVEA 158
Query: 133 HGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLP 192
HG+ C++C + + + VP + C + V+ + LP
Sbjct: 159 HGSFRTASCHLCYTSYPAAEAQAAI--MSDQVPVCSF------CAATVKPDVVFFGEDLP 210
Query: 193 ENDLLMAEWHSSIADLSICLGTTLQI 218
+ L AE ADL I +GT+LQ+
Sbjct: 211 QKYFLHAEDFPK-ADLLIIMGTSLQV 235
>UniRef50_Q0AY57 Cluster: Regulatory protein, sir2 family; n=1;
Syntrophomonas wolfei subsp. wolfei str. Goettingen|Rep:
Regulatory protein, sir2 family - Syntrophomonas wolfei
subsp. wolfei (strain Goettingen)
Length = 253
Score = 55.6 bits (128), Expect = 2e-06
Identities = 39/118 (33%), Positives = 54/118 (45%), Gaps = 21/118 (17%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGK-KPTINVS---------- 85
+ +++ S + VV TGAGIST AGIPDFRGP G++ E + IN+
Sbjct: 8 VVEILDRSHNTVVVTGAGISTEAGIPDFRGPEGIYRKLGENRVMKIINIDFFRNNPLEFY 67
Query: 86 --------FADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGN 135
F +P K H V+QNID LH K+G + + +HGN
Sbjct: 68 KFYRQYFIFPPVEPGKAHQVLAEMEKAGIIKAIVTQNIDNLHQKAGSQK--VIPIHGN 123
>UniRef50_A1A3R7 Cluster: Sir2-type regulatory protein; n=2;
Bifidobacterium adolescentis|Rep: Sir2-type regulatory
protein - Bifidobacterium adolescentis (strain ATCC
15703 / DSM 20083)
Length = 218
Score = 55.6 bits (128), Expect = 2e-06
Identities = 39/180 (21%), Positives = 77/180 (42%), Gaps = 1/180 (0%)
Query: 88 DAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNICKRQ 147
+AQP H +QN D LH K+G + LHG + C C +
Sbjct: 30 NAQPGTAHKALVKLEQAGLLTLLATQNFDALHEKAGNSSNVIVNLHGTIGTSHCMKCHAK 89
Query: 148 FVRSSPVETVGKKCSGVPCAAHHVTGR-PCRGRLYDGVLDWEHSLPENDLLMAEWHSSIA 206
+ + + + + +G PC G + V+ + +LP+ + + ++ A
Sbjct: 90 YDTAEIMANLDNEPDPHCHRKLPYSGNMPCDGLIKTDVVYFGEALPDGAIEKSYRLAAQA 149
Query: 207 DLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYYVDDVLEKVMD 266
D +G+TL+++P+ ++ + G + I N+ T++D A LI + L +++D
Sbjct: 150 DELWVIGSTLEVMPAASIVPVAAQAGVPITIMNMGRTQYDRLATRLIRDDIATALPQLVD 209
>UniRef50_A2DP91 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Trichomonas vaginalis G3|Rep:
Transcriptional regulator, Sir2 family protein -
Trichomonas vaginalis G3
Length = 267
Score = 55.6 bits (128), Expect = 2e-06
Identities = 73/267 (27%), Positives = 113/267 (42%), Gaps = 35/267 (13%)
Query: 37 LAQLVKDSK-HIVVHTGAGISTSAGIPDFRGPN--GVW------TLEKEG--KKPTIN-- 83
LA L++++K +I + TGAGIS +P FR + G+W +L+K +P ++
Sbjct: 8 LANLIRENKGNICIITGAGISAHV-LPTFRSSDSKGLWDVVADKSLDKFQFYSQPDVSWK 66
Query: 84 --VSFADAQ------PTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGN 135
S D Q P+K H ++QNID LH G K + ELHG
Sbjct: 67 LWASIRDLQKQKFLYPSKAHRVIHYLMKYGYIDTLLTQNIDSLHSFQGDESKII-ELHGK 125
Query: 136 MF-IDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPEN 194
+ EC C R+ +PV+ + SG C V C L V ++ +P+
Sbjct: 126 VTEFGECEKCNRK----TPVDHLKVLQSG-KCPKCPV----CNSNLRPTVAFFQDLIPKA 176
Query: 195 DLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLIN 254
A DL I +GT + P L E + G +V N T+ +K D+
Sbjct: 177 LRQKATKICQTTDLLILIGTHCVVDPVVTLVAEAFQSGATVVEINPDETRISDKCDMKFY 236
Query: 255 YYVDDVLEKVMDIL--GIEIPSYNESE 279
D+ L V +IL G++ + + E
Sbjct: 237 EKADEALVAVGNILFPGVDFENKTDVE 263
>UniRef50_Q96EB6 Cluster: NAD-dependent deacetylase sirtuin-1; n=29;
Euteleostomi|Rep: NAD-dependent deacetylase sirtuin-1 -
Homo sapiens (Human)
Length = 747
Score = 55.6 bits (128), Expect = 2e-06
Identities = 58/234 (24%), Positives = 95/234 (40%), Gaps = 37/234 (15%)
Query: 39 QLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT-----------------LEKEGKKPT 81
+L+++ K I+V TGAG+S S GIPDFR +G++ +E K P
Sbjct: 248 KLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPR 307
Query: 82 INVSFA------DAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGN 135
FA QP+ H +QNID L +G+ R + + HG+
Sbjct: 308 PFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQR--IIQCHGS 365
Query: 136 MFIDECNICKR----QFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSL 191
C ICK + VR V +C P +P ++ + +L
Sbjct: 366 FATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKP-------EIVFFGENL 418
Query: 192 PENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKH 245
PE ++ DL I +G++L++ P +P +I + ++ N +P H
Sbjct: 419 PEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIP-SSIPHEVPQILINREPLPH 471
>UniRef50_O59923 Cluster: NAD-dependent histone deacetylase SIR2;
n=3; Candida albicans|Rep: NAD-dependent histone
deacetylase SIR2 - Candida albicans (Yeast)
Length = 515
Score = 55.6 bits (128), Expect = 2e-06
Identities = 73/290 (25%), Positives = 121/290 (41%), Gaps = 33/290 (11%)
Query: 37 LAQLVKD---SKHIVVHTGAGISTSAGIPDFRGPNGVW------------------TLEK 75
L L+ D +K I+V TGAGISTS GIPDFR G++ T +
Sbjct: 224 LPDLISDLSRAKKIMVVTGAGISTSLGIPDFRSFKGLYNQLSKLNLSDPQKVFDLQTFMR 283
Query: 76 EGKK-PTIN--VSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAEL 132
EG+ TI V D + + H +QNID L ++G+ + L +
Sbjct: 284 EGRLFYTIAHLVLPPDGKFSLLHAFLKLLQDKHKLLRNYTQNIDNLEQRAGLKSEKLVQC 343
Query: 133 HGNMFIDECNICKRQFVRSSPVETVGKKCSGVP-CAA--HHVTGRPCR-GRLYDGVLDWE 188
HG+ +C C+ F + +K VP CA + P G + + +
Sbjct: 344 HGSFAKAKCVSCQGIFAGEKIYNHIRRK--QVPRCAICWKNTKQAPIHFGAIKPTITFFG 401
Query: 189 HSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNK 248
LPE + + DL + +GT+L++ P ++ +E + Y ++ N P +
Sbjct: 402 EDLPERFHTLMDKDLQQIDLFLVIGTSLKVEPVASI-IERVPYKVPKILINKDPIP-NRG 459
Query: 249 ADLLINYYVDDVLEKVMDILGIEIPSYNESEN-PMKFAETAIIDWSIDRK 297
+L + DD + + L +IP + + N +K ++ DW I K
Sbjct: 460 FNLQLLGLCDDAVSYLCKCLKWDIPHADFNNNDELKLSKLKNGDWEIVNK 509
>UniRef50_Q298C7 Cluster: GA18650-PA; n=1; Drosophila
pseudoobscura|Rep: GA18650-PA - Drosophila pseudoobscura
(Fruit fly)
Length = 381
Score = 55.2 bits (127), Expect = 3e-06
Identities = 54/202 (26%), Positives = 83/202 (41%), Gaps = 30/202 (14%)
Query: 45 KHIVVHTGAGISTSAGIPDFRG----------------PNGVWTLEKEGKKPTINVSFA- 87
K I+ GAGISTSAGIPDFR P ++ L KKP + A
Sbjct: 76 KKIITMVGAGISTSAGIPDFRSPGSGLYDNLAKYKLPYPTAIFELGYFKKKPAPFFALAK 135
Query: 88 -----DAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECN 142
+PT H +QNID L +G+P + L E HG+ + C
Sbjct: 136 ELYPGSFEPTTAHYFIRLLHEKGLLLRHYTQNIDTLDRLAGIPDEKLIEAHGSFHTNHCI 195
Query: 143 ICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAEWH 202
CK+++ + + + +P T C+ + ++ + +LPE +
Sbjct: 196 GCKKEYDMAWMKKEIFS--DRLP------TCTSCKKIVKPDIVFFGENLPEKFHNSLDGD 247
Query: 203 SSIADLSICLGTTLQIVPSGNL 224
DL I +GTTL++ P +L
Sbjct: 248 FKECDLLIIMGTTLEVHPFASL 269
>UniRef50_A7EMW8 Cluster: Putative uncharacterized protein; n=1;
Sclerotinia sclerotiorum 1980|Rep: Putative
uncharacterized protein - Sclerotinia sclerotiorum 1980
Length = 533
Score = 55.2 bits (127), Expect = 3e-06
Identities = 41/129 (31%), Positives = 60/129 (46%), Gaps = 21/129 (16%)
Query: 40 LVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT-LEKEG--------------KKPTI-- 82
L+K++K I+V TGAGISTS GIPDFR NG++ LE G + PTI
Sbjct: 203 LIKNAKKIIVITGAGISTSLGIPDFRSANGLYAQLEDTGLSDPQEVFNIDLFREDPTIFF 262
Query: 83 ----NVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFI 138
N+ + + + TH +QNIDG+ +G+ + + + HG+
Sbjct: 263 QIAKNILPSVVRFSPTHQFIKVLQDKGKLLTNYTQNIDGIESAAGILPENVIQCHGSFAT 322
Query: 139 DECNICKRQ 147
C C Q
Sbjct: 323 ATCQQCSTQ 331
>UniRef50_A2DKF0 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Trichomonas vaginalis G3|Rep:
Transcriptional regulator, Sir2 family protein -
Trichomonas vaginalis G3
Length = 347
Score = 54.8 bits (126), Expect = 3e-06
Identities = 63/213 (29%), Positives = 96/213 (45%), Gaps = 40/213 (18%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW-TLEKEG---------------KKP 80
+ +L+++SKHI+V GAG S PDFR P G++ ++ KEG K P
Sbjct: 61 IIKLIENSKHIIVIIGAGASIG---PDFRSPGGLYDSIAKEGCLEDPYQVFDLDYFKKDP 117
Query: 81 TINVSFA-----DAQP--TKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELH 133
TI FA D P + TH SQN+D L + GVP L +H
Sbjct: 118 TIFWRFAHKIFPDKNPAHSDTHYFIAELENHGKLQRLYSQNVDTL--ECGVPESKLRCVH 175
Query: 134 GNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDW-EHSLP 192
G+ C C ++F E V + VP PC G++ G++ + + +
Sbjct: 176 GSWRNSYCLSCGKKFDIEDLREAV--QNGTVPTC-------PCGGQIKPGIVFFGQKTNI 226
Query: 193 ENDLLMAEWHSSIADLSICLGTTLQIVPSGNLP 225
E++ + A+ S DL I +GT+L++ P LP
Sbjct: 227 EDEDITAD--SEEGDLLIVIGTSLKVAPISMLP 257
>UniRef50_A6WG46 Cluster: Silent information regulator protein Sir2;
n=4; Actinomycetales|Rep: Silent information regulator
protein Sir2 - Kineococcus radiotolerans SRS30216
Length = 279
Score = 54.4 bits (125), Expect = 5e-06
Identities = 66/276 (23%), Positives = 109/276 (39%), Gaps = 43/276 (15%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNG-----------VWTLEKEGKKPTINVS 85
LA L+ D +VV GAG+ST +GIPD+RGP G +T E ++ S
Sbjct: 7 LADLL-DGGRVVVLEGAGMSTGSGIPDYRGPGGSLQRHTPMTYQEFTGSAEARRRYWGRS 65
Query: 86 ------FADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFID 139
F A+P H ++QN+DGL L +G + + ELHGN+
Sbjct: 66 HVGWEHFRRARPNDAHRAVAALEGAGVVTGVITQNVDGLDLAAGT--REVVELHGNLDRV 123
Query: 140 ECNICKRQFVRSSPVETVGKKCSGVPCAAHH----------------------VTGRPC- 176
C C R+ E + G V R C
Sbjct: 124 VCLRCGELTARAELAERLSAANPGFDARVEQLHALNPDGDADLTEAQLEGFRTVACRRCG 183
Query: 177 RGRLYDGVLDWEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLV 236
L V+ + ++P++ + + A + + LG++L ++ L + G +
Sbjct: 184 EDALKADVVFFGETVPKDRVARSFELLDAARVLLVLGSSLAVMSGYRFVLHAARNGQPVA 243
Query: 237 ICNLQPTKHDNKADLLINYYVDDVLEKVMDILGIEI 272
I PT+ D KA L ++ + +VL V++ L + +
Sbjct: 244 IVTAGPTRGDEKAALKVDAPLQEVLPAVLERLRLRL 279
>UniRef50_Q81NT6 Cluster: NAD-dependent deacetylase; n=11; Bacillus
cereus group|Rep: NAD-dependent deacetylase - Bacillus
anthracis
Length = 242
Score = 54.4 bits (125), Expect = 5e-06
Identities = 57/248 (22%), Positives = 101/248 (40%), Gaps = 36/248 (14%)
Query: 40 LVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT---------------LEKEGKKPTINV 84
+++ +K I V TGAG ST +GIPDFR NG++ KE K +
Sbjct: 10 ILEKAKKITVLTGAGASTESGIPDFRSANGLYADANVEMYLSRGYYNRSPKEFWKHYKEI 69
Query: 85 ----SFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDE 140
+F +P + H ++QNIDGLH G K + +LHG +
Sbjct: 70 FQINTFHQYKPNRGHRFLAELEEQGKDITILTQNIDGLHQVGG--SKHVIDLHGTLQTAH 127
Query: 141 CNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAE 200
C CK + ++ +C C L V+ + +LP+ +
Sbjct: 128 CPKCKMGYDLQYMIDHEVPRC------------EKCNFILNPDVVLYGDTLPQYQNAIKR 175
Query: 201 WHSSIADLSICLGTTLQIVPSGNLP-LETIKYGGKLVICNLQPTKHDNKADLLINYYVDD 259
+ + D+ I +GT+L++ P + P + + G ++ N + T + D + + +
Sbjct: 176 LYET--DVLIVMGTSLKVQPVASFPQIAKREVGATTILVNEELTGQEYNFDYVFQNKIGE 233
Query: 260 VLEKVMDI 267
+E + I
Sbjct: 234 FVEGLSSI 241
>UniRef50_Q6BVM7 Cluster: Similar to CA4170|IPF7784 Candida
albicans; n=2; Saccharomycetaceae|Rep: Similar to
CA4170|IPF7784 Candida albicans - Debaryomyces hansenii
(Yeast) (Torulaspora hansenii)
Length = 301
Score = 54.0 bits (124), Expect = 6e-06
Identities = 35/116 (30%), Positives = 57/116 (49%), Gaps = 18/116 (15%)
Query: 44 SKHIVVHTGAGISTSAGIPDFRGPNGVW---------TLEKEGKKPTI--------NVSF 86
SK IV GAG+S S+G+P FRG G+W T + P + ++
Sbjct: 15 SKRIVALVGAGLSVSSGLPTFRGSQGLWKNFNMIDLATPDAFYIDPGLVWQFYSWRRINA 74
Query: 87 ADAQPTKTHMX-XXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDEC 141
+ A+P K H+ ++QN+DGL +++G P++ L E+HG++F C
Sbjct: 75 SKAKPNKGHLALAKLSKLSNIEFMTITQNVDGLLIRAGHPKEKLHEIHGSLFDLRC 130
>UniRef50_Q6BPH5 Cluster: Debaryomyces hansenii chromosome E of
strain CBS767 of Debaryomyces hansenii; n=2;
Saccharomycetaceae|Rep: Debaryomyces hansenii chromosome
E of strain CBS767 of Debaryomyces hansenii -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 573
Score = 54.0 bits (124), Expect = 6e-06
Identities = 67/262 (25%), Positives = 100/262 (38%), Gaps = 37/262 (14%)
Query: 41 VKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT----LEKEGKKPTINVSFADAQP----- 91
+K +K I+V TGAGISTS GIPDFR G ++ L + ++ F + P
Sbjct: 257 IKKAKKILVVTGAGISTSLGIPDFRSSKGFYSQLQYLGLSDPQEVFDLDFFHSDPNIFYL 316
Query: 92 ------------TKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFID 139
T H +QNID L G+ + L + HG+
Sbjct: 317 IAYMILPPEKSYTPLHAFIKLLQNKGKLLRNYTQNIDNLESNVGIKPEKLIQCHGSFATA 376
Query: 140 ECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDL--- 196
C CK Q + +K VP R D + + + + D+
Sbjct: 377 SCVTCKYQVKGEKIYPKIREK--EVPYCPKCKNARKILLNKEDAYVPESYGVMKPDITFF 434
Query: 197 ---LMAEWHSSI------ADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDN 247
L +H+ I DL I +GT+L++ P ++ +E I V+ N P H N
Sbjct: 435 GEPLPTRFHNMIRQDLMECDLLISIGTSLKVSPVADI-VERIPEHIPQVLINKDPIDHCN 493
Query: 248 KADLLINYYVDDVLEKVMDILG 269
D+ I Y DD + LG
Sbjct: 494 -FDVSILGYCDDTANYLCKRLG 514
>UniRef50_A2Q9C4 Cluster: Contig An01c0250, complete genome; n=18;
Pezizomycotina|Rep: Contig An01c0250, complete genome -
Aspergillus niger
Length = 495
Score = 54.0 bits (124), Expect = 6e-06
Identities = 46/152 (30%), Positives = 68/152 (44%), Gaps = 24/152 (15%)
Query: 18 LGVPEKFDSNDKLNQKCVL--LAQLVKDSKHIVVHTGAGISTSAGIPDFRG--------- 66
+ + +F KL Q + +L+K+SK+IVV TGAGISTS GIPDFR
Sbjct: 150 IAISREFSRRPKLPQYNTIDDAVKLLKESKNIVVLTGAGISTSLGIPDFRSKDTGLYSQL 209
Query: 67 -------PNGVWTLEKEGKKPTINVSFA-DAQPTK-----THMXXXXXXXXXXXXXXVSQ 113
P V+ ++ + P+I S A D PT+ TH +Q
Sbjct: 210 AHLGLSDPQEVFDIQVFREDPSIFFSIAKDILPTEKKFSPTHAFIRVLQDKGKLLTNYTQ 269
Query: 114 NIDGLHLKSGVPRKFLAELHGNMFIDECNICK 145
NID + +GV + + + HG+ C C+
Sbjct: 270 NIDNIEANAGVLPENIVQCHGSFATATCVKCQ 301
>UniRef50_Q885X7 Cluster: NAD-dependent deacetylase 2; n=4;
Pseudomonas|Rep: NAD-dependent deacetylase 2 -
Pseudomonas syringae pv. tomato
Length = 248
Score = 54.0 bits (124), Expect = 6e-06
Identities = 60/251 (23%), Positives = 100/251 (39%), Gaps = 33/251 (13%)
Query: 38 AQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKP----------------- 80
A ++ +K I+V TGAG+S +G+P +RG G++ E E P
Sbjct: 5 ASALRHAKRILVITGAGLSADSGLPTYRGVGGLYNGETEDGLPIEMALSGPMLRRDPELC 64
Query: 81 -----TINVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGN 135
+ + +P H ++QN+DG H +G P + L E+HG
Sbjct: 65 WKYIAELGKACLGGEPNVAHYAIAQLQRIKPECWVLTQNVDGYHRAAGSPPERLIEIHGQ 124
Query: 136 MFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPEND 195
+ C C Q + S E + + + C R C G L V+ ++ LPE
Sbjct: 125 LSPLFCQSCAAQDPQLS--EHLQRPLPPL-C-------RLCGGILRPPVVLFQEMLPERA 174
Query: 196 L-LMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLIN 254
L + E ++ D + +GTT + T GG N QPT H + D+ +
Sbjct: 175 LETLYEQLATGYDAVLSIGTTASFPYIHEPVIRTRVSGGFTAEINPQPTDHSAQMDVFLQ 234
Query: 255 YYVDDVLEKVM 265
V+ +++
Sbjct: 235 CRAAHVMAELI 245
>UniRef50_Q8FRV5 Cluster: NAD-dependent deacetylase 2; n=9;
Corynebacterineae|Rep: NAD-dependent deacetylase 2 -
Corynebacterium efficiens
Length = 254
Score = 54.0 bits (124), Expect = 6e-06
Identities = 53/209 (25%), Positives = 94/209 (44%), Gaps = 32/209 (15%)
Query: 40 LVKDSKHIVVHTGAGISTSAGIPDFRGPN-GVWTLEKEGKKPTINVSFAD---------- 88
+ + +++I V TGAG+S +G+ +R P GVW+ +I+ D
Sbjct: 12 VARGARNIEVFTGAGMSADSGLETYRDPETGVWSKVDPQAMASIDAWARDPEPMWAWYRW 71
Query: 89 -------AQPTKTH--MXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFID 139
A+P H + +QNID LH ++G + LHG++F
Sbjct: 72 RAGQAMKARPNAGHETIAYWEGSHLVDAVHVTTQNIDNLHERAGSTE--VTHLHGSLFEF 129
Query: 140 ECNICKRQFVRSS--PVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLL 197
C+IC + + P E V ++ + C+ + G P R GV+ + +LP+ +
Sbjct: 130 RCSICSKPWRDDGDYPREPV-ERLAPPTCS---LCGNPVR----PGVVWFGEALPQEEWA 181
Query: 198 MAEWHSSIADLSICLGTTLQIVPSGNLPL 226
+AE ADL + +GT+ + P+ +LP+
Sbjct: 182 VAERRMREADLVVIVGTSGIVYPAASLPV 210
>UniRef50_Q0LIC7 Cluster: Silent information regulator protein Sir2;
n=2; Bacteria|Rep: Silent information regulator protein
Sir2 - Herpetosiphon aurantiacus ATCC 23779
Length = 244
Score = 53.6 bits (123), Expect = 8e-06
Identities = 59/225 (26%), Positives = 93/225 (41%), Gaps = 31/225 (13%)
Query: 45 KHIVVHTGAGISTSAGIPDFRGPNGVWT---LEKEGKKPTINVS--------------FA 87
++IVV TGAGIS ++G+ FRGPNGVW +E+ + + S
Sbjct: 11 RNIVVLTGAGISVASGVRPFRGPNGVWNEWDIERCATRTALEQSPQLVWQAFGPLRSQLQ 70
Query: 88 DAQPTKTHMXXX---XXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNIC 144
QP H ++QNIDGLH +G + L E HG++ C+
Sbjct: 71 TTQPNAAHRALARFEQSLGKHQRFTLITQNIDGLHQLAG--SRNLVEFHGSLRQSRCS-- 126
Query: 145 KRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAEWHSS 204
Q + S V+ + C G+P R D VL +E ++P A+
Sbjct: 127 DEQCDQPSFVDQRAHTQTLPLCP---TCGKPLRP---DIVL-FEEAIPVWAETQAKRSLR 179
Query: 205 IADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKA 249
D + +GT+ + P+ G + ++ NL+P D+ A
Sbjct: 180 ECDFFLAVGTSGTVFPAAAFARTAQMLGARTMLVNLEPHAADDSA 224
>UniRef50_Q8SSB6 Cluster: SIR2-LIKE PROTEIN INVOLVED IN TELOMERIC
SILENCING; n=1; Encephalitozoon cuniculi|Rep: SIR2-LIKE
PROTEIN INVOLVED IN TELOMERIC SILENCING -
Encephalitozoon cuniculi
Length = 425
Score = 53.2 bits (122), Expect = 1e-05
Identities = 71/271 (26%), Positives = 112/271 (41%), Gaps = 46/271 (16%)
Query: 45 KHIVVHTGAGISTSAGIPDFRGPNGVW-------------------TLEKEGKKPTINV- 84
+ +VV TGAGIS S+GIPDFR +G++ ++ KE +K +
Sbjct: 86 RRVVVITGAGISVSSGIPDFRSKSGLFNDIKKDLGVSGNDLFTYSLSMSKELRKGYLRYI 145
Query: 85 ----SFAD-AQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVP-----RKFLAELHG 134
+ D AQP+ TH +QNIDGL K+G+ L LHG
Sbjct: 146 SKLKNMVDKAQPSATHEFLSLYSDISRRFRIYTQNIDGLEEKAGLAATKDRSTRLVYLHG 205
Query: 135 NMFIDECNICKRQFVRSSPVETVGKKCSGVPCAA----HHVTGRPCR----GRLYDGVLD 186
NM C C + + + CA + GR R G + ++
Sbjct: 206 NMKSLGCLYCGYKIEFGDAERDAYGRGEEIVCAGCVRRNEKRGRDVRKRPVGVFHTTIIH 265
Query: 187 WEHSLPENDLL--MAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYG---GKLVICNL- 240
+ S P++ + MAE H + DL I +GT+L++ L + G+ ++ NL
Sbjct: 266 YNQSHPDSSFISKMAE-HDNTCDLFIVMGTSLKVFGVRRLVKYFCRLNSTRGRRILVNLD 324
Query: 241 QPTKHDNKA-DLLINYYVDDVLEKVMDILGI 270
+P+K + D N D+ + D LG+
Sbjct: 325 RPSKEFGELFDFFWNGDCDEFCRVLKDGLGL 355
>UniRef50_A7SK95 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 323
Score = 52.8 bits (121), Expect = 1e-05
Identities = 73/290 (25%), Positives = 118/290 (40%), Gaps = 46/290 (15%)
Query: 20 VPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGP-NGVWTLEKEG- 77
VPE S +L+ L + + ++ I V TGAGIST +GI D+R G++ + +
Sbjct: 36 VPEFHTSKQELSYITSRLDEFIAENPKIFVITGAGISTESGIRDYRSEGKGLYAITNDRP 95
Query: 78 -------KKPTIN-----------VSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLH 119
K + F QP + H V+QN+D LH
Sbjct: 96 MEYQVFLKSAVMRQRYWARNYVGWPEFGSRQPNEAHYALAKLETLGSVHSLVTQNVDALH 155
Query: 120 LKSGVPRKFLAELHG---NMFIDECN-ICKRQFVRSSPVE------TVGKKCSGVPCAAH 169
K+G K + ELHG + CN I R ++ +E VG+ P
Sbjct: 156 TKAG--SKNVIELHGCSHRVICLGCNQITARTALQKRMIEFNPDWHAVGQ--GQAPDGDT 211
Query: 170 HVTGR--------PCR---GRLYDGVLDWEHSLPENDLLMAEWHSSIADLSICLGTTLQI 218
+T PC+ G L V+ + S+P+ + +A + +D +G+T+++
Sbjct: 212 FLTSEAVKDFKVPPCKACGGILKPEVVFFGDSVPKQIVNIAYDRLAESDALWIIGSTVEV 271
Query: 219 VPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYYVDDVLEKVMDIL 268
S E K G + I N+ T+ D A L ++ VL K +D+L
Sbjct: 272 YSSYRFATEASKQGKPIAILNIGKTRADKLASLKVSGVCGTVLPK-LDLL 320
>UniRef50_A5K7T7 Cluster: NAD-dependent deacetylase, putative; n=5;
Plasmodium|Rep: NAD-dependent deacetylase, putative -
Plasmodium vivax
Length = 306
Score = 52.8 bits (121), Expect = 1e-05
Identities = 57/230 (24%), Positives = 96/230 (41%), Gaps = 26/230 (11%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNG-------------VWTLEKEGKK--PT 81
LA +++ ++V TG+G S + IP FRG N +W K +K
Sbjct: 21 LACMIRGCTYVVALTGSGTSAESNIPSFRGANSSIWSKYDPKIYGTIWGFWKSPEKIWEV 80
Query: 82 INVSFAD--AQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFID 139
I +D + H ++QNIDGLH +SG + + LHG++F
Sbjct: 81 IRDISSDYEIELNPGHTALSKLESLGYLKTVITQNIDGLHEESGNSK--VIPLHGSVFEA 138
Query: 140 ECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGR-PCRGRLYDGVLDWEHSLPENDLLM 198
C C R+ ++ + + +K S H + PC G V+ + +P++ L
Sbjct: 139 RCCTC-RETIQLNKIML--QKTSHF---MHQLPPECPCGGIFKPNVVLFGEVIPKSLLKQ 192
Query: 199 AEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNK 248
AE DL + +GT+ + + NL + K+V N+ T N+
Sbjct: 193 AEKEIDKCDLLLVIGTSSTVSTATNLCYHAHRKKKKIVEVNISKTYITNR 242
>UniRef50_A4RCT8 Cluster: Putative uncharacterized protein; n=3;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 1040
Score = 52.8 bits (121), Expect = 1e-05
Identities = 37/115 (32%), Positives = 52/115 (45%), Gaps = 17/115 (14%)
Query: 44 SKHIVVHTGAGISTSAGIPDFRGPNGVWTLEK-------EG--KKPTINVSFAD------ 88
S++IV GAG+S S+G+ FRGP G+W + G P + F
Sbjct: 33 SRNIVAIIGAGLSASSGLATFRGPGGLWQNQDVFVLASPAGFVNDPGLVWQFYSYRREEA 92
Query: 89 --AQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDEC 141
AQP K H ++QN+D L ++G P L ELHGN+F +C
Sbjct: 93 LKAQPNKAHRALAELARKVPGFTMLTQNVDNLSPRAGHPADQLLELHGNLFDLKC 147
>UniRef50_Q046W9 Cluster: NAD-dependent protein deacetylase, SIR2
family; n=6; Lactobacillus|Rep: NAD-dependent protein
deacetylase, SIR2 family - Lactobacillus gasseri (strain
ATCC 33323 / DSM 20243)
Length = 237
Score = 52.4 bits (120), Expect = 2e-05
Identities = 37/133 (27%), Positives = 58/133 (43%), Gaps = 22/133 (16%)
Query: 30 LNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTI------- 82
LN + L + ++ H+ TGAG+ST + IPD+R NG++ E + +
Sbjct: 3 LNNQIAALQADLNNAHHVTYLTGAGVSTPSHIPDYRSKNGIYNGISESPEQILSEDTLFH 62
Query: 83 -----------NVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAE 131
N+ F +AQP H ++QN+DGL K+G K + E
Sbjct: 63 EPAKFHHFVMENMYFPNAQPNIIHQ--KIAASCNKNGTLITQNVDGLDKKAG--NKHVIE 118
Query: 132 LHGNMFIDECNIC 144
HGN++ C C
Sbjct: 119 FHGNLYNIFCTKC 131
>UniRef50_Q011Q8 Cluster: NAD-dependent deacetylase SIRT2; n=2;
Ostreococcus|Rep: NAD-dependent deacetylase SIRT2 -
Ostreococcus tauri
Length = 394
Score = 52.4 bits (120), Expect = 2e-05
Identities = 55/203 (27%), Positives = 81/203 (39%), Gaps = 32/203 (15%)
Query: 44 SKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSF----------------- 86
+K++VV TGAGIS SAGIPDFR +G++ E P F
Sbjct: 103 AKNVVVMTGAGISVSAGIPDFRSESGLYARLGEYDLPYPQAVFELGYFKDRPGPFYRLAK 162
Query: 87 ----ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECN 142
PT TH +QNID L +G+P++ + HGN D +
Sbjct: 163 ELYPGAFAPTPTHYFIKLLHDKGILRRCFTQNIDSLERATGLPKEKVVPAHGN--FDGAH 220
Query: 143 ICKRQFVRSSPVETVGKKC-SGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAEW 201
C R + V+ V C +G P C + ++ + +LP A+
Sbjct: 221 -CLRG--HEADVDEVADACRAGTPMIC-----SKCGEYVKPDIVFFGENLPRRFFECAQE 272
Query: 202 HSSIADLSICLGTTLQIVPSGNL 224
+ DL I +GT+L + P L
Sbjct: 273 DFEVCDLLIVIGTSLVVHPFAGL 295
>UniRef50_Q1RL71 Cluster: Zinc finger protein; n=2; Ciona
intestinalis|Rep: Zinc finger protein - Ciona
intestinalis (Transparent sea squirt)
Length = 523
Score = 52.4 bits (120), Expect = 2e-05
Identities = 62/266 (23%), Positives = 106/266 (39%), Gaps = 44/266 (16%)
Query: 37 LAQLVKDS--KHIVVHTGAGISTSAGIPDFRGPN-GVWTLEKEGKKPTINVSF------- 86
+A+L+ ++I+V GAGIST +GIPDFR P G++ + K P F
Sbjct: 110 VAELISSGGVRNIIVMAGAGISTGSGIPDFRTPGTGLYDNLHKYKIPAPTAVFDRDYFNV 169
Query: 87 ---------------ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAE 131
+P H +QNIDGL +G+P L E
Sbjct: 170 NPKPFFELAKELYPSGKYRPNIVHYFVRCLHEKGLLLRMYTQNIDGLERLAGIPPSKLVE 229
Query: 132 LHGNMFIDEC----NICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDW 187
HG C CK + ++ ++ V +C P C G + ++ +
Sbjct: 230 AHGTFSTASCTKCGKKCKGEVIKDKILKGVIPRCQLTPL---------CYGTIKPDIVFF 280
Query: 188 EHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQP----T 243
LP+ + S DL + GT+LQ+ P +L +++ ++ ++ N+
Sbjct: 281 GEDLPKRFYYYLKDFPS-CDLLLVFGTSLQVEPFASL-VDSARFTTPRLLLNMVKVGPFV 338
Query: 244 KHDNKADLLINYYVDDVLEKVMDILG 269
K + DL + + D ++ +D LG
Sbjct: 339 KRGRRHDLAVTGDIMDSIQTFVDELG 364
>UniRef50_A2F8N6 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Trichomonas vaginalis G3|Rep:
Transcriptional regulator, Sir2 family protein -
Trichomonas vaginalis G3
Length = 320
Score = 52.4 bits (120), Expect = 2e-05
Identities = 55/232 (23%), Positives = 94/232 (40%), Gaps = 33/232 (14%)
Query: 43 DSKHIVVHTGAGISTSAGIPDFRGPN-GVWTLEKEGKKPTINVSF--------------- 86
++K I++ +GAG S ++GIPDFR P G+++ K+ P F
Sbjct: 35 NAKKILIFSGAGTSVASGIPDFRSPKIGLYSQLKKYNLPRPESIFTRDYFKYHPEPFFSL 94
Query: 87 ------ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDE 140
+P+ H SQNIDGL +G+ + L E HG +
Sbjct: 95 IKFFLPGKYKPSPAHFLAKLFENHGILLRHYSQNIDGLDKAAGLSEEHLVEWHGTLSKAT 154
Query: 141 CNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAE 200
C C +++ ++ + K A V C G + V+ + ++ +
Sbjct: 155 CRKCSKKYT----LDDIKPK-----ILAEAVPRCSCGGVIQPDVMLYGDYNDDDLYTHLD 205
Query: 201 WHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPT-KHDNKADL 251
ADL LGT+L++ P ++ +E + Y V+ N P +D K D+
Sbjct: 206 KDVEQADLLFVLGTSLKVEPFPSM-IENVSYSIPRVLINADPVCTYDEKLDI 256
>UniRef50_A2F8E1 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Trichomonas vaginalis G3|Rep:
Transcriptional regulator, Sir2 family protein -
Trichomonas vaginalis G3
Length = 331
Score = 52.4 bits (120), Expect = 2e-05
Identities = 64/248 (25%), Positives = 100/248 (40%), Gaps = 42/248 (16%)
Query: 34 CVLLAQLVKDS--KHIVVHTGAGISTSAGIPDFRGPN-GVWTLEKEGKK-----PT---- 81
C +LAQ + K+++V TGAGIST+AGIPDFR P G++ K + PT
Sbjct: 7 CEILAQKIISGNYKNVIVLTGAGISTAAGIPDFRSPAIGIYATLKSASRLKFRDPTFVFD 66
Query: 82 INVSFAD-----------------AQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGV 124
I+V D +PT+ H +QN+DGL + G+
Sbjct: 67 IDVFMDDPKPFWWIFSHLWPKDLWPRPTEMHYFIGYLNQLGVLKRVYTQNVDGLEIPGGL 126
Query: 125 PRKFLAELHGNMFIDECNICK-----RQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRG- 178
P L + HG + C C + +R ++ + H C G
Sbjct: 127 PEDKLVQCHGALPTCHCCDCHAAVPLAECLRQIQPNFENRRLNMTNAVVPHCPS--CDGE 184
Query: 179 RLYDGVLDWEHSLPE--NDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLV 236
+ V + ++P+ L ++HS DL I GT+L + P +L +E + G
Sbjct: 185 HVKPDVTFFGEAMPDRFEQTLYEDFHS--CDLCIITGTSLGVYPFADL-VEEVPAGIPRF 241
Query: 237 ICNLQPTK 244
+ N K
Sbjct: 242 VINYDKVK 249
>UniRef50_A0C6J0 Cluster: Chromosome undetermined scaffold_152,
whole genome shotgun sequence; n=1; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_152,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 449
Score = 52.4 bits (120), Expect = 2e-05
Identities = 54/203 (26%), Positives = 81/203 (39%), Gaps = 32/203 (15%)
Query: 42 KDSKHIVVHTGAGISTSAGIPDFR----------------GPNGVWTLEKEGKKPTINVS 85
K + + V GAG+S +AGIPDFR P V+ +E K P
Sbjct: 207 KKFQRVCVLAGAGMSVAAGIPDFRTPGTGLYSQIQKYNLPSPESVFEIEYFKKNPEAFYC 266
Query: 86 FA-------DAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFI 138
A DA+PT H +QNIDGL L +GV + + + HG+M
Sbjct: 267 VAKEFLLSFDAKPTLAHKFLKFLDSRGQLLKCFTQNIDGLELDAGVSQDKVIQAHGHMRT 326
Query: 139 DECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLM 198
C C+ + + + K H P +G + V+ + LP
Sbjct: 327 ARCIECQEEVSIKDFMSHIKKG------DIHRCEKCPKKGLVKPDVVFFGEGLPGE--FF 378
Query: 199 AEWHS-SIADLSICLGTTLQIVP 220
W+ ADL I +GT+L+++P
Sbjct: 379 YSWNCLKDADLLIVIGTSLKVMP 401
>UniRef50_Q8FUC8 Cluster: NAD-dependent deacetylase 1; n=6;
Corynebacterium|Rep: NAD-dependent deacetylase 1 -
Corynebacterium efficiens
Length = 281
Score = 52.4 bits (120), Expect = 2e-05
Identities = 37/121 (30%), Positives = 55/121 (45%), Gaps = 19/121 (15%)
Query: 47 IVVHTGAGISTSAGIPDFRGPNGV------WTLEKEGKKPTINVSF-----------ADA 89
++ TGAG+ST +GIPD+R P G T ++ P + + ADA
Sbjct: 19 VLAVTGAGVSTDSGIPDYRSPRGSLNQGRPMTYQEFRFDPVASHRYWARSFVGWRVMADA 78
Query: 90 QPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNICKRQFV 149
QP +TH V+QN+DGLH ++G + L LHG++ C C +
Sbjct: 79 QPNRTHYALVELERAGLLSGIVTQNVDGLHRRAG--SENLVALHGDLATIVCLQCGHREA 136
Query: 150 R 150
R
Sbjct: 137 R 137
>UniRef50_Q839C6 Cluster: NAD-dependent deacetylase; n=14;
Bacilli|Rep: NAD-dependent deacetylase - Enterococcus
faecalis (Streptococcus faecalis)
Length = 237
Score = 52.0 bits (119), Expect = 2e-05
Identities = 53/188 (28%), Positives = 82/188 (43%), Gaps = 37/188 (19%)
Query: 51 TGAGISTSAGIPDFRGPNGVWT-------------LEKEGKK--PTINVSF-ADAQPTKT 94
TGAGIST++G+PD+R GV+ L+ E +K + + DAQP
Sbjct: 23 TGAGISTASGVPDYRSLKGVYQGIQQPEYLLSRTCLKTEPEKFYQFVKTLYHPDAQPNII 82
Query: 95 HMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNICKRQFVRSSPV 154
H VSQNIDGLH K+G + + + HGN++ C C
Sbjct: 83 HQKMAQLEQMKRGKI-VSQNIDGLHRKAG--SQEVVDFHGNLYECYCQTCG--------- 130
Query: 155 ETVGKKCSGVPCAAHHVTGR--PCRGRLYDGVLDWEHSLPENDLLMAEWHSSIADLSICL 212
+ VP + ++ R C G++ + +E L E + A + ADL + +
Sbjct: 131 -------ATVPWQDYLLSDRHADCHGQIRPAITLYEEGLSEEAIEKAIQAVASADLIVIV 183
Query: 213 GTTLQIVP 220
GT+ Q+ P
Sbjct: 184 GTSFQVHP 191
>UniRef50_P53686 Cluster: NAD-dependent deacetylase HST2; n=4;
Saccharomyces cerevisiae|Rep: NAD-dependent deacetylase
HST2 - Saccharomyces cerevisiae (Baker's yeast)
Length = 357
Score = 52.0 bits (119), Expect = 2e-05
Identities = 72/262 (27%), Positives = 106/262 (40%), Gaps = 45/262 (17%)
Query: 47 IVVHTGAGISTSAGIPDFRGPN-GVWTLEKEGKKP----TINVSFADA------------ 89
++ GAGISTS GIPDFR P G++ K P +V F +
Sbjct: 27 VIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKEL 86
Query: 90 -----QPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNIC 144
+P+K H +QNID L ++GV + E HG+ C C
Sbjct: 87 YPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGC 146
Query: 145 KRQFVRSSPVETVGKKCSGVPCAAH---HVTGRPCRGRLYDGVLDWEHSLPENDLLMAEW 201
+ + P + K + P V G + + D S E L +EW
Sbjct: 147 GKVY----PPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEW 202
Query: 202 -HSSIAD--------LSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKA--- 249
I L I +GT+L + P +LP E I K V+CNL+ T D KA
Sbjct: 203 LREKITTSGKHPQQPLVIVVGTSLAVYPFASLP-EEIPRKVKRVLCNLE-TVGDFKANKR 260
Query: 250 --DLLINYYVDDVLEKVMDILG 269
DL+++ Y D+ E++++ LG
Sbjct: 261 PTDLIVHQYSDEFAEQLVEELG 282
>UniRef50_Q6AF12 Cluster: Regulatory protein, Sir2 family; n=2;
Actinobacteria (class)|Rep: Regulatory protein, Sir2
family - Leifsonia xyli subsp. xyli
Length = 283
Score = 51.6 bits (118), Expect = 3e-05
Identities = 38/127 (29%), Positives = 56/127 (44%), Gaps = 17/127 (13%)
Query: 41 VKDSKHIVVHTGAGISTSAGIPDFRGPNGV---------WTLEKEGKKPTINVS------ 85
V + V TGAG+ST +GIPD+RG + E +K S
Sbjct: 24 VLSGRRFAVLTGAGVSTDSGIPDYRGEGAPKRTPMTFQQFLAEDRHRKRYWAGSHLGYRR 83
Query: 86 FADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNICK 145
F+ A+P H V+QN+DGLH K+G R + +LHG++ C +C
Sbjct: 84 FSAARPNDGHRALAALEDAGAAAGVVTQNVDGLHKKAGSRR--VVDLHGSVDRVLCLVCG 141
Query: 146 RQFVRSS 152
+ F R +
Sbjct: 142 QLFAREA 148
>UniRef50_A6RRE3 Cluster: Putative uncharacterized protein; n=1;
Botryotinia fuckeliana B05.10|Rep: Putative
uncharacterized protein - Botryotinia fuckeliana B05.10
Length = 526
Score = 51.6 bits (118), Expect = 3e-05
Identities = 36/127 (28%), Positives = 55/127 (43%), Gaps = 21/127 (16%)
Query: 39 QLVKDSKHIVVHTGAGISTSAGIPDFRGPNG---------------VWTLEKEGKKPTIN 83
+L++ +K I+V TGAGISTS GIPDFR NG ++ +EK + P+I
Sbjct: 198 ELIRGAKKIIVITGAGISTSLGIPDFRSANGLYAQFGHLNLNDPQEIFNIEKFKEDPSIF 257
Query: 84 VSFADA------QPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMF 137
A + + TH +QNID + +G+ + HG+
Sbjct: 258 FGVAKVILPEIRRFSPTHQFIALLQAHGKLLTNYTQNIDNIESMAGISPDKIIHCHGSFA 317
Query: 138 IDECNIC 144
C +C
Sbjct: 318 TATCQVC 324
>UniRef50_A5DSX8 Cluster: NAD-dependent histone deacetylase SIR2;
n=1; Lodderomyces elongisporus NRRL YB-4239|Rep:
NAD-dependent histone deacetylase SIR2 - Lodderomyces
elongisporus (Yeast) (Saccharomyces elongisporus)
Length = 568
Score = 51.6 bits (118), Expect = 3e-05
Identities = 63/264 (23%), Positives = 106/264 (40%), Gaps = 38/264 (14%)
Query: 40 LVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKE---------------GKKPTINV 84
L++ S I+V TGAGISTS GIPDFR G +++ + P++
Sbjct: 252 LIQKSHKILVITGAGISTSLGIPDFRSSQGFYSMVQHLGLSDPQEVFDLLIFNSDPSLFY 311
Query: 85 SFAD--AQPTKT----HMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFI 138
S A P T H +QNID L +G+ + + + HG+
Sbjct: 312 SIAHMVLPPENTFSPLHSFIYLLQQKGKLLRNYTQNIDNLESYAGIVPEKMVQCHGSFAT 371
Query: 139 DECNICKRQFVRSSPVETVGKKCSGVP-CAAHHVTGRPCRGRLYDGVLDWEHSLPENDL- 196
C C+ + +T+ +K +P C + + D + + + D+
Sbjct: 372 ATCVTCRNTVAGETIFKTIRQK--EIPYCPRCEAKKKSILKKNDDYYFPESYGVYKPDIT 429
Query: 197 -----LMAEWHSSI------ADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKH 245
L + +H I DL I +GT+L++ P ++ ++ I ++ N P H
Sbjct: 430 FFGEALPSRFHDLINTDISECDLLISIGTSLKVAPVADI-VDKIPQNIPQILINRDPIDH 488
Query: 246 DNKADLLINYYVDDVLEKVMDILG 269
N D+ + Y DDV + LG
Sbjct: 489 CN-FDISLLGYCDDVAALISHRLG 511
>UniRef50_A3LN35 Cluster: NAD-dependent histone deacetylase SIR2;
n=1; Pichia stipitis|Rep: NAD-dependent histone
deacetylase SIR2 - Pichia stipitis (Yeast)
Length = 391
Score = 51.6 bits (118), Expect = 3e-05
Identities = 70/268 (26%), Positives = 108/268 (40%), Gaps = 32/268 (11%)
Query: 36 LLAQLVKDSKHIVVHTGAGISTSAGIPDFRG---------------PNGVWTLEKEGKKP 80
LL+ L +K I+V +GAGISTS GIPDFR P V+ + K P
Sbjct: 103 LLSDLTS-AKKIMVISGAGISTSLGIPDFRSFKGLYAQLEHLNLKDPQKVFDMGAFQKDP 161
Query: 81 TINVSFA------DAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHG 134
+I S A + + + H +QNID L + G+ L + HG
Sbjct: 162 SIFYSIAHLVLPPEGRFSMLHSFIKLLQDKGKLLRNYTQNIDNLESRVGIHPDKLIQCHG 221
Query: 135 NMFIDECNICKRQFVRSSPVETVGKKCSGVP-CAAHHVTGRPC---RGRLYDGVLDWEHS 190
+ C C +F E + + VP C+ T + G + + +
Sbjct: 222 SFGSASCLTCSNRFAGHKIFEHI--RHQHVPRCSTCWKTIQEAVIIHGVIKPDITFFGED 279
Query: 191 LPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKAD 250
LP+ + E DL I +GT+L++ P ++ ++ I V+ N P D D
Sbjct: 280 LPKKFYRLLEPDCQTCDLVIVVGTSLKVEPVSSI-IDKIPRSVPRVLINKDPIP-DRDFD 337
Query: 251 LLINYYVDDVLEKVMDILGI--EIPSYN 276
L + DDV+ + LG +IP N
Sbjct: 338 LSLIGLCDDVVCHLTRELGASWDIPHPN 365
>UniRef50_UPI00015B4FA0 Cluster: PREDICTED: similar to chromatin
regulatory protein sir2; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to chromatin regulatory protein sir2
- Nasonia vitripennis
Length = 736
Score = 51.2 bits (117), Expect = 4e-05
Identities = 62/271 (22%), Positives = 102/271 (37%), Gaps = 43/271 (15%)
Query: 36 LLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSFADA------ 89
+L V S I V TGAGIST +GIPD+R GV ++P F +
Sbjct: 466 MLKHFVNTSGKICVITGAGISTESGIPDYRS-EGVGLFATSDRRPVSYQDFCKSDKTRRR 524
Query: 90 ---------------QPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHG 134
QP TH ++QN+D LH+K+G K + ELHG
Sbjct: 525 YWARNYAAWPRFSLFQPNVTHKWLKNMEDIGKVSCVITQNVDNLHIKAG--SKNVVELHG 582
Query: 135 NMFIDECNICKRQFVRSSPVETVGKKCSGV--PCAAHHVTG-----------------RP 175
+ C C + R E + K + C A G
Sbjct: 583 TGYRVVCLSCNNKIDRFVFQEVLNKLNPDMKASCEAIRPDGDVDLSQDQIDDFKIPPCSK 642
Query: 176 CRGRLYDGVLDWEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKL 235
C G + ++ + ++P+ + + AD + LGT+L + L+ ++ +
Sbjct: 643 CGGIMKPDIVFFGDNVPKQVVERVQNEVEEADSLLVLGTSLTTFSGYRIVLQAVEAVKPI 702
Query: 236 VICNLQPTKHDNKADLLINYYVDDVLEKVMD 266
I N+ T+ D A + ++ ++L + D
Sbjct: 703 AILNIGDTRGDEHAQIRVHGRCGEILPMLTD 733
>UniRef50_A5WD15 Cluster: Silent information regulator protein Sir2;
n=2; Psychrobacter|Rep: Silent information regulator
protein Sir2 - Psychrobacter sp. PRwf-1
Length = 249
Score = 51.2 bits (117), Expect = 4e-05
Identities = 57/251 (22%), Positives = 100/251 (39%), Gaps = 37/251 (14%)
Query: 40 LVKDSKHIVVHTGAGISTSAGIPDFRGPN-GVWTLEKEGKKPTINVS------------- 85
L+ + I + TGAGIS +GIP FR G+W + IN
Sbjct: 11 LISKANRIFLLTGAGISAESGIPTFRDKQTGLWENYRAEDLANINAFKKDPQTVWSWYQW 70
Query: 86 ----FADAQPTKTHMXXXXXXXXXXXX----XXVSQNIDGLHLKSGVPRKFLAELHGNMF 137
D QP H ++QN+D LH ++G LHG+++
Sbjct: 71 RRGLVQDKQPNPAHYALANLQQWATDNHKDCSLITQNVDDLHEQAGSQA---IHLHGHLW 127
Query: 138 IDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLL 197
++C+ C F S ++ + P H+ RP ++ + LP+
Sbjct: 128 KNKCSQCDASF--SDAIDYNDLQLLSCPMCGGHI--RP-------DIVWFGEMLPQGAWQ 176
Query: 198 MAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYYV 257
AE + D+ I +GT+ + P+ L + G K++ NL PT+ D+++
Sbjct: 177 YAEEAAVHCDVFISIGTSSLVYPAAGLAQLAKQTGAKVIEINLNPTQ-SPLVDVVLAGQA 235
Query: 258 DDVLEKVMDIL 268
++L +++ L
Sbjct: 236 GEILPRILAAL 246
>UniRef50_Q2H5A0 Cluster: Putative uncharacterized protein; n=1;
Chaetomium globosum|Rep: Putative uncharacterized
protein - Chaetomium globosum (Soil fungus)
Length = 387
Score = 51.2 bits (117), Expect = 4e-05
Identities = 41/128 (32%), Positives = 56/128 (43%), Gaps = 23/128 (17%)
Query: 44 SKHIVVHTGAGISTSAGIPDFRGP-NGVW----TLEKEGKKPTINVSF------------ 86
++ IVV TGAGIST+AGIPDFR P G++ L + ++SF
Sbjct: 34 ARRIVVMTGAGISTAAGIPDFRSPTTGLYANLSALNLPEPEAVFDLSFFRQNPQPFYVLA 93
Query: 87 ------ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDE 140
A +PT +H +QNID L +GVP + E HG+
Sbjct: 94 RELYPGARYRPTISHAFLALLARRGLLHMLFTQNIDCLERAAGVPADRIVEAHGSFASQR 153
Query: 141 CNICKRQF 148
C CK +F
Sbjct: 154 CVDCKGEF 161
>UniRef50_Q88ZA0 Cluster: NAD-dependent deacetylase; n=4;
Lactobacillus|Rep: NAD-dependent deacetylase -
Lactobacillus plantarum
Length = 234
Score = 51.2 bits (117), Expect = 4e-05
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 22/122 (18%)
Query: 41 VKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKE----------GKKP-------TIN 83
++ ++HIV TGAG+ST +GIPD+R NG++T + P N
Sbjct: 11 LQQAQHIVFMTGAGVSTPSGIPDYRSKNGLYTEHHNAEYYLSHAFLAEHPLEFYQYLQSN 70
Query: 84 VSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKF-LAELHGNMFIDECN 142
+ + DAQP H ++QNID L+ GV + L E HGN++ C
Sbjct: 71 LYYPDAQPNVIHQ-KMAALTQQGRASVITQNIDNLY---GVAKTAQLVEFHGNLYQVYCT 126
Query: 143 IC 144
C
Sbjct: 127 KC 128
>UniRef50_UPI0000499DEA Cluster: Sir2 family transcriptional
regulator; n=1; Entamoeba histolytica HM-1:IMSS|Rep:
Sir2 family transcriptional regulator - Entamoeba
histolytica HM-1:IMSS
Length = 383
Score = 50.8 bits (116), Expect = 6e-05
Identities = 53/205 (25%), Positives = 84/205 (40%), Gaps = 34/205 (16%)
Query: 45 KHIVVHTGAGISTSAGIPDFRGPN-GVW-TLEKEGKK-----------PTINVSFADAQ- 90
K+I+ GAG+ST+AGIPDFR P G++ L+K P+ F +
Sbjct: 135 KNIIALVGAGMSTTAGIPDFRSPRTGLYFNLQKYNLPYPEAVFDMNYFPSNPAPFYEVMK 194
Query: 91 ----------PTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDE 140
PTK H +QNIDGL +G+P + HG
Sbjct: 195 VMFPGQGTYFPTKCHRFLKLLNDKGILKMVYTQNIDGLESVAGIPNDKVICSHGTFRSSH 254
Query: 141 CNICKRQFVRSSP-VETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMA 199
C C +++ +S +E++ KK + C C G + ++ + SLP+
Sbjct: 255 CLSCHKKYPDTSVFIESI-KKGEIIHC--------NCGGLIKPDIVFFNESLPDEFFESI 305
Query: 200 EWHSSIADLSICLGTTLQIVPSGNL 224
+ D+ + +GT L + P NL
Sbjct: 306 KDKFDDCDMLLIIGTALVVYPFANL 330
>UniRef50_Q0UNC9 Cluster: Putative uncharacterized protein; n=1;
Phaeosphaeria nodorum|Rep: Putative uncharacterized
protein - Phaeosphaeria nodorum (Septoria nodorum)
Length = 479
Score = 50.8 bits (116), Expect = 6e-05
Identities = 51/215 (23%), Positives = 87/215 (40%), Gaps = 27/215 (12%)
Query: 38 AQLVKDSKHIVVHTGAGISTSAGIPDFRGPN-GVWT----LEKEGKKPTINVSFADAQP- 91
A+L+++ K+I++ TGAGISTS GIPDFR N G ++ + E + ++ D P
Sbjct: 167 AKLLRERKNIMIITGAGISTSLGIPDFRSKNTGFYSRLLQMGYEEPEQVFDIHNFDEDPR 226
Query: 92 ----------------TKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGN 135
T TH +QNID + +G+ + L + HG+
Sbjct: 227 TFYALAGDIIPDLEKWTPTHEFIRLLQDKEKLLTNYTQNIDNVEANAGILKDKLIQCHGS 286
Query: 136 MFIDECNICKRQFVRSSPVETVG----KKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSL 191
C + Q ++ KK S + P G + + + +L
Sbjct: 287 WATATCREMQTQPLKRKRTSNGSGPRKKKSSDEDSESDGAYDIPQPGIMKPDITFFGEAL 346
Query: 192 PENDL-LMAEWHSSIADLSICLGTTLQIVPSGNLP 225
P N + + DL I +GT++++ P +P
Sbjct: 347 PNNFFDRLKDVDKDKVDLVIVMGTSMKVAPVSEIP 381
>UniRef50_A5DNV7 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 403
Score = 50.8 bits (116), Expect = 6e-05
Identities = 54/209 (25%), Positives = 84/209 (40%), Gaps = 26/209 (12%)
Query: 40 LVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT-LEKEG--------------KKPTINV 84
+++ +K I+V TGAGISTS GIPDFR G+++ L + G K PT+
Sbjct: 112 VLEKAKKILVVTGAGISTSLGIPDFRSFQGIYSQLSRSGLENAQQVFHIDRFCKDPTLFY 171
Query: 85 SFAD---AQPTKT---HMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFI 138
A Q K H +QNID L L +G+ + HG +
Sbjct: 172 LVAHKILPQGDKVSDFHRFLRLLEQKNKLLRVYTQNIDNLELAAGIDPSRIVHCHGTLST 231
Query: 139 DECNICKRQFVRSSPVETVGKKCSGVPCAAHHVT---GRPCRGRLYDGVLDWEHSLPEND 195
C C+ F ++ + K VP + VT P +G + + + L
Sbjct: 232 STCLTCRATFSGAATFAAI--KMRQVPYCSLCVTDLGSVPMKGLIKPDITFFGEDLSSRF 289
Query: 196 LLMAEWHSSIADLSICLGTTLQIVPSGNL 224
M DL + GT+L++ P ++
Sbjct: 290 ETMIGKDVEECDLLLVAGTSLKVEPVASI 318
>UniRef50_Q9FY91 Cluster: SIR2-family protein; n=12;
Magnoliophyta|Rep: SIR2-family protein - Arabidopsis
thaliana (Mouse-ear cress)
Length = 451
Score = 50.4 bits (115), Expect = 7e-05
Identities = 39/135 (28%), Positives = 55/135 (40%), Gaps = 27/135 (20%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVS----------- 85
L +L + S + + TGAG+ST GIPD+R PNG ++ G KP +
Sbjct: 161 LYRLFEQSSRLTILTGAGVSTECGIPDYRSPNGAYS---SGFKPITHQEFTRSSRARRRY 217
Query: 86 ----------FADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGN 135
F AQP H ++QN+D LH ++G ELHG
Sbjct: 218 WARSYAGWRRFTAAQPGPAHTALASLEKAGRINFMITQNVDRLHHRAGSDP---LELHGT 274
Query: 136 MFIDECNICKRQFVR 150
++ C C F R
Sbjct: 275 VYTVMCLECGFSFPR 289
Score = 41.9 bits (94), Expect = 0.026
Identities = 24/99 (24%), Positives = 49/99 (49%)
Query: 176 CRGRLYDGVLDWEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKL 235
C+G L V+ + ++P+ A + +D + LG++L + + L + G
Sbjct: 352 CKGVLKPDVIFFGDNIPKERATQAMEVAKQSDAFLVLGSSLMTMSAFRLCRAAHEAGAMT 411
Query: 236 VICNLQPTKHDNKADLLINYYVDDVLEKVMDILGIEIPS 274
I N+ T+ D+ L IN V ++L +V+D+ + +P+
Sbjct: 412 AIVNIGETRADDIVPLKINARVGEILHRVLDVGSLSVPA 450
>UniRef50_Q7S6G9 Cluster: Putative uncharacterized protein
NCU04737.1; n=3; Sordariomycetes|Rep: Putative
uncharacterized protein NCU04737.1 - Neurospora crassa
Length = 670
Score = 50.4 bits (115), Expect = 7e-05
Identities = 43/128 (33%), Positives = 55/128 (42%), Gaps = 22/128 (17%)
Query: 39 QLVKDSKHIVVHTGAGISTSAGIPDFRG----------------PNGVWTLEKEGKKPTI 82
+L+K SK+I+V TGAGISTS GIPDFR P V+ + + P I
Sbjct: 201 ELLKRSKNIIVLTGAGISTSLGIPDFRSKGTGLYSKLEHLGLSDPQEVFDINIFRQDPNI 260
Query: 83 NVSFA-DAQP-----TKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNM 136
S A D P + TH SQNID L K+G+ L + HG+
Sbjct: 261 FYSVARDILPNTERFSPTHAFIALLQQKGKLLTNYSQNIDNLEAKAGIHPDKLVQCHGSF 320
Query: 137 FIDECNIC 144
C C
Sbjct: 321 ATATCVKC 328
>UniRef50_Q8IRR5 Cluster: CG3187-PC, isoform C; n=4; Diptera|Rep:
CG3187-PC, isoform C - Drosophila melanogaster (Fruit
fly)
Length = 312
Score = 50.0 bits (114), Expect = 1e-04
Identities = 37/135 (27%), Positives = 59/135 (43%), Gaps = 24/135 (17%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSFADA------- 89
L + +++V TGAGIST +GIPD+R GV + KP ++ F +
Sbjct: 38 LEDFLLSKPNVLVLTGAGISTESGIPDYRS-EGVGLYARSNHKPVQHMEFVKSSAVRKRY 96
Query: 90 --------------QPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGN 135
QP TH V+QN+D LH K+G + + E+HG+
Sbjct: 97 WARNFVGWPKFSATQPNATHHALARFEREERVQAVVTQNVDRLHTKAG--SRNVVEVHGS 154
Query: 136 MFIDECNICKRQFVR 150
++ +C C+ + R
Sbjct: 155 GYVVKCLSCEYRIDR 169
>UniRef50_Q22ZC3 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Tetrahymena thermophila SB210|Rep:
Transcriptional regulator, Sir2 family protein -
Tetrahymena thermophila SB210
Length = 308
Score = 50.0 bits (114), Expect = 1e-04
Identities = 57/208 (27%), Positives = 85/208 (40%), Gaps = 32/208 (15%)
Query: 40 LVKDSKHIVVHTGAGISTSAGIPDFRGP-NGVWT-LEKE-----------------GKKP 80
L K K I TGAGIS SAGIPDFR P G++ ++KE P
Sbjct: 63 LAKKYKQIAFLTGAGISVSAGIPDFRSPETGLYAQIKKEYDISDPQKIFSIRYYQDNPLP 122
Query: 81 TINV--SF--ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNM 136
+ V F + PT H ++QNIDGL LK+G+ + + HG+M
Sbjct: 123 FMQVIRDFFSREYHPTYAHKLIHQIYKRKQLLINITQNIDGLELKTGINPSKVVQAHGHM 182
Query: 137 FIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDL 196
C C V +ET + C + + C + ++ + LP N+
Sbjct: 183 RKAHCVNC-NHIVN---IETYLQNCKQLKKTQCPI----CNNLVKPKIVFFGEFLP-NEF 233
Query: 197 LMAEWHSSIADLSICLGTTLQIVPSGNL 224
+ +D + +GT+L + P NL
Sbjct: 234 YQSRDILPNSDCVVVMGTSLGVFPFANL 261
>UniRef50_Q6ZMU6 Cluster: CDNA FLJ16662 fis, clone TESTI4046240,
highly similar to Homo sapiens sirtuin 7; n=1; Homo
sapiens|Rep: CDNA FLJ16662 fis, clone TESTI4046240,
highly similar to Homo sapiens sirtuin 7 - Homo sapiens
(Human)
Length = 162
Score = 50.0 bits (114), Expect = 1e-04
Identities = 20/29 (68%), Positives = 26/29 (89%)
Query: 111 VSQNIDGLHLKSGVPRKFLAELHGNMFID 139
VSQN DGLHL+SG+PR ++ELHGNM+I+
Sbjct: 16 VSQNCDGLHLRSGLPRTAISELHGNMYIE 44
>UniRef50_Q6FKU1 Cluster: Similar to sp|P53686 Saccharomyces
cerevisiae YPL015c; n=3; Saccharomycetales|Rep: Similar
to sp|P53686 Saccharomyces cerevisiae YPL015c - Candida
glabrata (Yeast) (Torulopsis glabrata)
Length = 364
Score = 50.0 bits (114), Expect = 1e-04
Identities = 62/265 (23%), Positives = 104/265 (39%), Gaps = 42/265 (15%)
Query: 44 SKHIVVHTGAGISTSAGIPDFRGPN----------------GVWTLEKEGKKPTINVSFA 87
S ++ GAGISTS+GIPDFR P V+ +E + P A
Sbjct: 16 SSKVIFLVGAGISTSSGIPDFRSPKTGLYHNLSKLKLPYAEAVFDIEYYQENPQPFYLLA 75
Query: 88 DA------QPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDEC 141
D +P+K H +QNID L ++G+P +L E HG+ + C
Sbjct: 76 DELYPGNFKPSKFHYLMKVLEKNGRLRRVYTQNIDTLEREAGIPDDYLVEAHGSFAKNHC 135
Query: 142 NICKRQFVRSSPVETVGK------KCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLP--- 192
C ++F + + + K + ++ C + ++ + +LP
Sbjct: 136 IGCDKEFPLDDFKKALLRYNKYKMKHNNDMKEFEYLRCPECEALIKPKIVFFGENLPKRF 195
Query: 193 ----ENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPT----K 244
+ DL E S+ + I GT+L + P +LP + + V+CNL
Sbjct: 196 FDSWDTDLEWLEEESN--SIVIVAGTSLTVYPFASLP-NDVPNNVRRVLCNLDVVGDFLT 252
Query: 245 HDNKADLLINYYVDDVLEKVMDILG 269
DL + + DD +++ LG
Sbjct: 253 SPRDMDLKFSEHTDDFANQLVKELG 277
>UniRef50_Q6C219 Cluster: Yarrowia lipolytica chromosome F of strain
CLIB122 of Yarrowia lipolytica; n=1; Yarrowia
lipolytica|Rep: Yarrowia lipolytica chromosome F of
strain CLIB122 of Yarrowia lipolytica - Yarrowia
lipolytica (Candida lipolytica)
Length = 320
Score = 50.0 bits (114), Expect = 1e-04
Identities = 65/258 (25%), Positives = 110/258 (42%), Gaps = 44/258 (17%)
Query: 19 GVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNG--------- 69
G E ++ K++ LL +L + +++IVV GAGISTS GIPDFR +G
Sbjct: 36 GDVESLAAHSKIHTFGDLLREL-ETAQNIVVLCGAGISTSLGIPDFRSADGLYKSLDLES 94
Query: 70 --------VWTLEKEGKKPT--INVSFADAQPTK-----THMXXXXXXXXXXXXXXVSQN 114
V+ LE + PT V+ PT+ TH +QN
Sbjct: 95 LGLSDPQEVFDLEVFDQDPTPFYRVASKVMMPTQALISPTHAFLKLLQDKGKLLRIYTQN 154
Query: 115 IDGLHLKSGVPRKFLAELHGNMFIDECNICKRQFVRSS--PVETVGKKCSGVPCAAHHVT 172
ID L +G+ + + HG + C C + S P G+ +P
Sbjct: 155 IDDLEHIAGIEESKMVQCHGAFHMATCRQCGAKVTCESLRPEIVAGE----IPMCRR--- 207
Query: 173 GRPCRGRLYDGVLDWEHSLPE-------NDLLMAEWHSSIADLSICLGTTLQIVPSGNLP 225
+ C G + ++ + +LP+ +D++M + DL +CLGT+L++ P+ ++
Sbjct: 208 -KRCEGVIKPDIVFFGEALPDRFRHMVRSDIIMGGPTPKV-DLFLCLGTSLKVSPACDI- 264
Query: 226 LETIKYGGKLVICNLQPT 243
+ + G V N +P+
Sbjct: 265 AKQVPLGVPRVYINREPS 282
>UniRef50_Q0CR31 Cluster: NAD-dependent histone deacetylase SIR2;
n=2; Pezizomycotina|Rep: NAD-dependent histone
deacetylase SIR2 - Aspergillus terreus (strain NIH 2624)
Length = 1068
Score = 50.0 bits (114), Expect = 1e-04
Identities = 45/151 (29%), Positives = 66/151 (43%), Gaps = 24/151 (15%)
Query: 18 LGVPEKFDSNDKLNQKCVL--LAQLVKDSKHIVVHTGAGISTSAGIPDFRG--------- 66
+ + +F KL Q + +L+++SK+IVV TGAGISTS GIPDFR
Sbjct: 148 IAISREFSRRPKLPQYNSIDDAVKLLQESKNIVVLTGAGISTSLGIPDFRSKDTGLYSQL 207
Query: 67 -------PNGVWTLEKEGKKPTINVSFA-DAQPTK-----THMXXXXXXXXXXXXXXVSQ 113
P V+ + + P+I S A D PT+ TH +Q
Sbjct: 208 EHLGLSDPQEVFDIHVFREDPSIFFSIAKDILPTEKKYSPTHGFIRLLQDKGKLLTNYTQ 267
Query: 114 NIDGLHLKSGVPRKFLAELHGNMFIDECNIC 144
NID + +GV + + + HG+ C C
Sbjct: 268 NIDNIEANAGVVPEKIVQCHGSFATATCVKC 298
>UniRef50_A6G0H3 Cluster: Silent information regulator protein Sir2;
n=1; Plesiocystis pacifica SIR-1|Rep: Silent information
regulator protein Sir2 - Plesiocystis pacifica SIR-1
Length = 288
Score = 49.6 bits (113), Expect = 1e-04
Identities = 41/112 (36%), Positives = 49/112 (43%), Gaps = 24/112 (21%)
Query: 47 IVVHTGAGISTSAGIPDFRGPNGVW-------------TLEKEGKKPTI---------NV 84
+VV TGAGIS +GIP FRGP G W T E GK P V
Sbjct: 31 VVVTTGAGISAESGIPTFRGPEGYWTVGAKEYRPQELATREAFGKLPKEVWRWYLYRKGV 90
Query: 85 SFADAQPTKTHMXXXXXXXXXXXXX-XVSQNIDGLHLKSGVPRKFLAELHGN 135
A A P H V+QN+DGLHL++G R+ E+HGN
Sbjct: 91 CNA-AAPNPAHEALVRLEQALGERFCLVTQNVDGLHLRAGNSRERTIEVHGN 141
>UniRef50_Q6C8C7 Cluster: Similar to DEHA0C01507g Debaryomyces
hansenii IPF 2468.1; n=2; Ascomycota|Rep: Similar to
DEHA0C01507g Debaryomyces hansenii IPF 2468.1 - Yarrowia
lipolytica (Candida lipolytica)
Length = 303
Score = 49.6 bits (113), Expect = 1e-04
Identities = 58/232 (25%), Positives = 95/232 (40%), Gaps = 34/232 (14%)
Query: 44 SKHIVVHTGAGISTSAGIPDFRGPNGVW---------TLEKEGKKPTINVSF-------- 86
S+ I+ GAG+S S+G+P FRG G+W T E P+ F
Sbjct: 16 SRKILALVGAGLSQSSGLPTFRGEGGIWRNYDAAELATPEAFHNDPSTVWQFYAHRRHMS 75
Query: 87 ADAQPTKTHMX-XXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECN--I 143
A+P H ++QN+DGL ++ P++ L +LHG++F +C
Sbjct: 76 LKAKPNPGHYALAELARRLRGRFLTLTQNVDGLSSRAEHPQEALLKLHGDLFALKCTSFF 135
Query: 144 C----KRQFVRS-SPVETVGKKCSGVPCAAHHV------TGRPCR-GRLYDGVLDWEHSL 191
C + F +P ++ + H + T C+ G L GV+ + SL
Sbjct: 136 CSYTTEDNFADPLTPALSITDNYNSAQLQRHRIPVEDLPTCPHCKEGLLRPGVVWFGESL 195
Query: 192 PENDLLMAE--WHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQ 241
P + A+ DL I +GT+ + P+ GGK+ I N++
Sbjct: 196 PFKVMNTADEFLEDEDVDLIIVVGTSGSVWPAAGYVERVALSGGKVAIFNME 247
>UniRef50_A4QX96 Cluster: Putative uncharacterized protein; n=2;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 534
Score = 49.6 bits (113), Expect = 1e-04
Identities = 59/211 (27%), Positives = 83/211 (39%), Gaps = 35/211 (16%)
Query: 47 IVVHTGAGISTSAGIPDFRGP-NGVW------TLEKEGKKPTINVSFADAQ--------- 90
I++ GAGISTSAGIPDFR P G++ +L+ IN + Q
Sbjct: 38 IIILAGAGISTSAGIPDFRSPKTGLYDNLARFSLDSPTDVFDINFFRTNPQPFYSLAPEL 97
Query: 91 ------PTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNIC 144
PT +H +QNIDGL +GVP + E HG+ C C
Sbjct: 98 YPGRYAPTISHAFVALLARKGLLAMLFTQNIDGLEKAAGVPPDLVVEAHGSFDSQRCIDC 157
Query: 145 KRQF--------VRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPE-ND 195
++F V +S V G KC G+ G R + E LP+
Sbjct: 158 AQEFPAADMRAHVATSSVPHCG-KCGGLVKPDIVFFGEQLPDRFFRA---REAHLPDLEG 213
Query: 196 LLMAEWHSSIADLSICLGTTLQIVPSGNLPL 226
+ E + I +GT+L + P LP+
Sbjct: 214 APIPEILGGARQVVIVMGTSLSVPPFCELPV 244
>UniRef50_UPI00015B57C0 Cluster: PREDICTED: similar to GA18743-PA;
n=1; Nasonia vitripennis|Rep: PREDICTED: similar to
GA18743-PA - Nasonia vitripennis
Length = 871
Score = 49.2 bits (112), Expect = 2e-04
Identities = 42/142 (29%), Positives = 62/142 (43%), Gaps = 26/142 (18%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT-----------------LEKEGKK 79
+ +L+K+SK+I+V TGAG+S S GIPDFR +G+++ + +
Sbjct: 197 VVELIKNSKNIIVLTGAGVSVSCGIPDFRSRDGIYSRLAQDFPDLPDPQAMFDINYFSQD 256
Query: 80 PTINVSFA------DAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELH 133
P FA +P+ H SQNID L +G+ L E H
Sbjct: 257 PRPFFKFAREIYPGQFKPSPCHQFIKMLEKQKKLLRNYSQNIDTLERVAGINN--LIECH 314
Query: 134 GNMFIDECNICKRQFVRSSPVE 155
G+ C CK Q V+S V+
Sbjct: 315 GSFATASCTKCKYQ-VKSDDVK 335
>UniRef50_Q5KA61 Cluster: Histone deacetylase, putative; n=1;
Filobasidiella neoformans|Rep: Histone deacetylase,
putative - Cryptococcus neoformans (Filobasidiella
neoformans)
Length = 596
Score = 49.2 bits (112), Expect = 2e-04
Identities = 43/132 (32%), Positives = 60/132 (45%), Gaps = 26/132 (19%)
Query: 40 LVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT-LEKEGK-----------------KPT 81
L+ SK I+V +GAGISTS GIPDFR G++ L++EGK KP
Sbjct: 152 LLAKSKKIIVLSGAGISTSCGIPDFRSSTGLYAQLQEEGKYELDDPQQMFDIRYFREKPE 211
Query: 82 INVSFA------DAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGN 135
+ SFA + P+ H +QNID L +GV R + + HG+
Sbjct: 212 VFYSFAKQIYPSNFVPSPCHRWIKMLEDRGVLLRNYTQNIDTLESLAGVER--VLQCHGS 269
Query: 136 MFIDECNICKRQ 147
C CK++
Sbjct: 270 FKTASCLRCKQR 281
>UniRef50_A5DJ74 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 522
Score = 49.2 bits (112), Expect = 2e-04
Identities = 66/262 (25%), Positives = 101/262 (38%), Gaps = 37/262 (14%)
Query: 41 VKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT-LEKEG--------------KKPTINVS 85
++ +K I+V +GAGISTS GIPDFR G + LE G PT+
Sbjct: 206 LQSAKKILVLSGAGISTSLGIPDFRSSQGFYAKLEHLGLSDPQDVFDLGIFHTDPTVFYL 265
Query: 86 FA------DAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFID 139
A + T H +QNID L G+ + + HG+
Sbjct: 266 IAHMILPPEHSFTPMHAFIKTLDDKGILLRNYTQNIDNLESNVGINSDRVVQCHGSFATA 325
Query: 140 ECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPEND---- 195
C CK E + K V R D + + + + D
Sbjct: 326 TCVTCKNTIPGHEIFECIRNK--EVAYCTKCTNSRLALMDKDDAYVPESYGVMKPDITFF 383
Query: 196 --LLMAEWHSSI------ADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDN 247
LL A++H +I DL I +GT+L++ P ++ ++ + ++ N P H N
Sbjct: 384 GELLPAKFHDTINEDLHECDLVISVGTSLKVAPVADI-VDKVPPSVPQILINRDPITHCN 442
Query: 248 KADLLINYYVDDVLEKVMDILG 269
D+ + Y DDV E + LG
Sbjct: 443 -FDVSLLGYCDDVAELLERKLG 463
>UniRef50_Q21921 Cluster: NAD-dependent deacetylase SIR2 homolog;
n=2; Caenorhabditis|Rep: NAD-dependent deacetylase SIR2
homolog - Caenorhabditis elegans
Length = 607
Score = 48.8 bits (111), Expect = 2e-04
Identities = 59/254 (23%), Positives = 100/254 (39%), Gaps = 35/254 (13%)
Query: 39 QLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT-LEKE----------------GKKPT 81
+L K KHI+V TGAG+S S GIPDFR +G++ L E + P
Sbjct: 140 ELFKTKKHILVLTGAGVSVSCGIPDFRSKDGIYARLRSEFPDLPDPTAMFDIRYFRENPA 199
Query: 82 INVSFA------DAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGN 135
+FA P+ +H +QNID L ++G+ R + E HG+
Sbjct: 200 PFYNFAREIFPGQFVPSVSHRFIKELETSGRLLRNYTQNIDTLEHQTGIKR--VVECHGS 257
Query: 136 MFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPEND 195
C C +++ + E V A + C G + ++ + L
Sbjct: 258 FSKCTCTRCGQKYDGNEIREEV--------LAMRVAHCKRCEGVIKPNIVFFGEDLGREF 309
Query: 196 LLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINY 255
DL + +G++L++ P +P + ++ N + H N AD+ +
Sbjct: 310 HQHVTEDKHKVDLIVVIGSSLKVRPVALIP-HCVDKNVPQILINRESLPHYN-ADIELLG 367
Query: 256 YVDDVLEKVMDILG 269
DD++ + LG
Sbjct: 368 NCDDIIRDICFSLG 381
>UniRef50_A1CTI6 Cluster: SIR2 family histone deacetylase, putative;
n=8; Eurotiomycetidae|Rep: SIR2 family histone
deacetylase, putative - Aspergillus clavatus
Length = 320
Score = 48.4 bits (110), Expect = 3e-04
Identities = 33/120 (27%), Positives = 52/120 (43%), Gaps = 17/120 (14%)
Query: 39 QLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW---------TLEKEGKKPTINVSF--- 86
+ +K K I+ GAG+S S+G+P FRG G+W T E P + F
Sbjct: 16 EYLKGCKRIIALCGAGLSASSGLPTFRGAGGLWRSYEAMDLATPEAFEANPDLVWHFYSY 75
Query: 87 -----ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDEC 141
A+P + H ++QN+D L ++ P + L LHG++F +C
Sbjct: 76 RRHMALKAKPNRAHYALAELARRNRDFITLTQNVDDLSQRANHPSEQLHLLHGSLFTVKC 135
>UniRef50_O94640 Cluster: NAD-dependent histone deacetylase sir2;
n=1; Schizosaccharomyces pombe|Rep: NAD-dependent
histone deacetylase sir2 - Schizosaccharomyces pombe
(Fission yeast)
Length = 475
Score = 48.4 bits (110), Expect = 3e-04
Identities = 42/142 (29%), Positives = 61/142 (42%), Gaps = 21/142 (14%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT-LEKEG--------------KKPT 81
+ L+K +K++VV GAGISTS GI DFR NG + L + G + P
Sbjct: 149 VVNLLKKAKNVVVLVGAGISTSLGILDFRSDNGFYARLARHGLSEPSEMFDIHTFRENPE 208
Query: 82 INVSFA-DAQP-----TKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGN 135
I +FA D P + +H +QNID L K+G+ + + HG+
Sbjct: 209 IFYTFARDLLPETNHYSPSHAFIRLLEKKNKLSTLFTQNIDNLEKKTGLSDNKIIQCHGS 268
Query: 136 MFIDECNICKRQFVRSSPVETV 157
C CK + S E +
Sbjct: 269 FATATCIKCKHKVDGSELYEDI 290
>UniRef50_Q21KQ1 Cluster: Silent information regulator protein Sir2;
n=2; Gammaproteobacteria|Rep: Silent information
regulator protein Sir2 - Saccharophagus degradans
(strain 2-40 / ATCC 43961 / DSM 17024)
Length = 235
Score = 48.0 bits (109), Expect = 4e-04
Identities = 38/124 (30%), Positives = 52/124 (41%), Gaps = 21/124 (16%)
Query: 42 KDSKHIVVHTGAGISTSAGIPDFRGPNGVW---------TLEKEGKKPTINVSFAD---- 88
KD K IVV TGAG+S +G+ FR NG+W T E + P + F +
Sbjct: 5 KDYKRIVVLTGAGVSAESGLKTFRDNNGLWENHRVEDVATPEAYARNPELVQKFYNARRS 64
Query: 89 -----AQPTKTHMX-XXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECN 142
AQP K H V+QN+D LH G K L +HG + C
Sbjct: 65 QLLTAAQPNKAHTALGEFEQHFSGEFLLVTQNVDNLHELGG--SKNLIHMHGELLKARCP 122
Query: 143 ICKR 146
+ ++
Sbjct: 123 VSEK 126
>UniRef50_A3LRA1 Cluster: Transcriptional regulatory protein; n=2;
Saccharomycetales|Rep: Transcriptional regulatory
protein - Pichia stipitis (Yeast)
Length = 311
Score = 48.0 bits (109), Expect = 4e-04
Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 23/135 (17%)
Query: 30 LNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSFAD- 88
++++ V + +K + IV GAG+S S+G+P FRG G+W T + + D
Sbjct: 1 MSKQLVEFQEYLKTCRKIVALVGAGLSVSSGLPTFRGSQGLWKNFNMIDLATPDAFYIDP 60
Query: 89 ----------------AQPTKTHMXXXXXXXXXX------XXXXVSQNIDGLHLKSGVPR 126
A+P K H+ ++QN+DGL +SG +
Sbjct: 61 GLVWQFYSWRRYNALQAKPNKGHLALSALSNLATRKDSNLEYITITQNVDGLSSRSGHAK 120
Query: 127 KFLAELHGNMFIDEC 141
+ L E+HG++F C
Sbjct: 121 ENLYEIHGSLFNLNC 135
>UniRef50_Q9I4E1 Cluster: NAD-dependent deacetylase 2; n=6;
Pseudomonadaceae|Rep: NAD-dependent deacetylase 2 -
Pseudomonas aeruginosa
Length = 256
Score = 47.6 bits (108), Expect = 5e-04
Identities = 62/253 (24%), Positives = 98/253 (38%), Gaps = 35/253 (13%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPT--------------- 81
+AQ ++ ++ I+V TGAG+S +G+P +RG G++ E P
Sbjct: 10 VAQALRRAERILVITGAGLSADSGMPTYRGLGGLYNGRTEEGLPIEAALSGPMLRRDPAL 69
Query: 82 -------INVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHG 134
+ + A+P H ++QNIDG H ++G P + L E+HG
Sbjct: 70 CWKYLAELGKACLAARPNAGHEAIAELQKHKPECWVLTQNIDGFHRQAGSPAERLIEIHG 129
Query: 135 NMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPEN 194
+ C C + S +E CAA C G L V+ +E LPE
Sbjct: 130 ELAPLYCQSCGAE---SGGLEEHLHGQLPPRCAA-------CGGVLRPPVVLFEEMLPEE 179
Query: 195 --DLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLL 252
D L E D + +GTT L T + GG N T + D+
Sbjct: 180 AIDTLYRELRKGF-DAVLVVGTTASFPYIVEPVLRTRQAGGFTAEVNPGVTDLSERVDVK 238
Query: 253 INYYVDDVLEKVM 265
+ D++ +V+
Sbjct: 239 MTGRALDIMPQVV 251
>UniRef50_A6R1B0 Cluster: Predicted protein; n=2; Onygenales|Rep:
Predicted protein - Ajellomyces capsulatus NAm1
Length = 547
Score = 47.2 bits (107), Expect = 7e-04
Identities = 26/55 (47%), Positives = 35/55 (63%), Gaps = 1/55 (1%)
Query: 36 LLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW-TLEKEGKKPTINVSFADA 89
LL + ++ + IVV GAGIS SAGIPDFR +G++ TL+K+ K T DA
Sbjct: 94 LLLKALQKKRKIVVIAGAGISVSAGIPDFRSAHGLFKTLKKDHKLKTSGKQLFDA 148
>UniRef50_Q7QZ36 Cluster: GLP_464_21655_23334; n=1; Giardia lamblia
ATCC 50803|Rep: GLP_464_21655_23334 - Giardia lamblia
ATCC 50803
Length = 559
Score = 46.8 bits (106), Expect = 0.001
Identities = 35/130 (26%), Positives = 59/130 (45%), Gaps = 22/130 (16%)
Query: 41 VKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT-LEKEG-KKPT--INVSF---------- 86
++ ++ ++ GAGIS SAGIPDFR NG++ L++ +KPT N+ F
Sbjct: 160 LRRARKVIFLVGAGISVSAGIPDFRSKNGIYNRLQQYNLQKPTDMFNLDFFRGNPIPFYR 219
Query: 87 --------ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFI 138
+PT H+ +QNID L +++ + +K++ HG+
Sbjct: 220 FCPEIFPGPQFKPTVVHLFMRLLEKRGQLQRIYTQNIDCLEVQAQITQKYIINCHGSFHT 279
Query: 139 DECNICKRQF 148
C C +F
Sbjct: 280 FTCIDCGAKF 289
>UniRef50_Q4DP02 Cluster: Silent information regulator 2, putative;
n=4; Trypanosoma|Rep: Silent information regulator 2,
putative - Trypanosoma cruzi
Length = 359
Score = 46.8 bits (106), Expect = 0.001
Identities = 57/203 (28%), Positives = 83/203 (40%), Gaps = 35/203 (17%)
Query: 47 IVVHTGAGISTSAGIPDFRGPN-------GVWTLEKEG---------KKPTINVSFADAQ 90
I+V GAGIS +AGIPDFR P+ G + L ++P + S
Sbjct: 32 ILVMAGAGISVAAGIPDFRSPHTGIYARLGKYNLNSPTDAFSITLLRERPDVFYSIVREM 91
Query: 91 --------PTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECN 142
PT H +QNIDGL SG+P FL E HG+ C
Sbjct: 92 DLWPGHFWPTLVHHFIKLLADEGRLLRCCTQNIDGLERASGLPMSFLVEAHGSFSTASCI 151
Query: 143 ICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDL-LMAEW 201
C+ + +E ++ S H R C G + V+ + SLP+ + AE
Sbjct: 152 ECRSPY----DIELASRE-SREGKVPH--CDR-CGGVVKPDVVFFGESLPDAFFNVFAE- 202
Query: 202 HSSIADLSICLGTTLQIVPSGNL 224
+ +L + +GT+LQ+ P L
Sbjct: 203 -ITEVELLLIMGTSLQVHPFAEL 224
>UniRef50_O96505 Cluster: SIR2; n=4; Sophophora|Rep: SIR2 -
Drosophila melanogaster (Fruit fly)
Length = 823
Score = 46.8 bits (106), Expect = 0.001
Identities = 20/32 (62%), Positives = 25/32 (78%)
Query: 40 LVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 71
LVK S+ I+V TGAG+S S GIPDFR NG++
Sbjct: 215 LVKKSQKIIVLTGAGVSVSCGIPDFRSTNGIY 246
>UniRef50_A2GAR7 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Trichomonas vaginalis G3|Rep:
Transcriptional regulator, Sir2 family protein -
Trichomonas vaginalis G3
Length = 312
Score = 46.8 bits (106), Expect = 0.001
Identities = 52/198 (26%), Positives = 81/198 (40%), Gaps = 31/198 (15%)
Query: 51 TGAGISTSAGIPDFRGPN-GVWTLEKEGKKP----TINVSFADA---------------- 89
TGAG S ++GIPDFR P G++ + K P ++ F D
Sbjct: 40 TGAGTSVASGIPDFRTPKIGLYANLDKYKLPYPEAVFDIEFFDTNPGPFFDVCRNILPGT 99
Query: 90 -QPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNICKRQF 148
+P+ H +QNID L + +G+P + E HG+ C C +F
Sbjct: 100 FKPSPAHYLPVLFDKHKLLTRLYTQNIDSLDISAGLPLDKIVEAHGSFTYLTCRKCGSKF 159
Query: 149 VRSSPVETVGKKCSGVPCAAHHVTGRPCR-GRLYDGVLDWEHSLPENDLLMAEWHSSIAD 207
+ E + V C R C+ G + V+ + LP+ ++E S A+
Sbjct: 160 EFADYKEEF-QTGKVVHC-------RECKEGVIKPDVVFYGEDLPQRFHHLSENDFSTAN 211
Query: 208 LSICLGTTLQIVPSGNLP 225
L I +GT+L + P LP
Sbjct: 212 LLIIMGTSLTVSPCCMLP 229
>UniRef50_Q5AQ47 Cluster: Potential Sir2 family histone deacetylase;
n=2; Candida albicans|Rep: Potential Sir2 family histone
deacetylase - Candida albicans (Yeast)
Length = 657
Score = 46.8 bits (106), Expect = 0.001
Identities = 20/35 (57%), Positives = 29/35 (82%)
Query: 39 QLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTL 73
+L+++SK+I+V TGAGISTS GIPDFR G +++
Sbjct: 296 KLIENSKNIMVITGAGISTSLGIPDFRSSQGFYSM 330
>UniRef50_Q8R216 Cluster: NAD-dependent deacetylase sirtuin-4; n=7;
cellular organisms|Rep: NAD-dependent deacetylase
sirtuin-4 - Mus musculus (Mouse)
Length = 333
Score = 46.8 bits (106), Expect = 0.001
Identities = 41/140 (29%), Positives = 57/140 (40%), Gaps = 24/140 (17%)
Query: 32 QKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINV------- 84
+K L + + SK ++V TGAGIST + IPD+R V + ++P ++
Sbjct: 39 EKIKELQRFISLSKKLLVMTGAGISTESSIPDYRSEK-VGLYARTDRRPIQHIDFVRSAP 97
Query: 85 --------------SFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLA 130
F+ QP H V+QN+D LH K+G R L
Sbjct: 98 VRQRYWARNFVGWPQFSSHQPNPAHWALSNWERLGKLHWLVTQNVDALHSKAGSQR--LT 155
Query: 131 ELHGNMFIDECNICKRQFVR 150
ELHG M C C Q R
Sbjct: 156 ELHGCMHRVLCLNCGEQTAR 175
>UniRef50_Q89EA6 Cluster: NAD-dependent deacetylase 2; n=9;
Proteobacteria|Rep: NAD-dependent deacetylase 2 -
Bradyrhizobium japonicum
Length = 273
Score = 46.8 bits (106), Expect = 0.001
Identities = 37/140 (26%), Positives = 59/140 (42%), Gaps = 19/140 (13%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW----------------TLEKEGKKP 80
L V + + V TGAG ST++GIPD+R +G W T + +
Sbjct: 11 LQDFVARHQRLFVLTGAGCSTNSGIPDYRDSHGNWKRTQPVNFQAFMSEEHTRRRYWARS 70
Query: 81 TIN-VSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFID 139
I F A+P H ++QN+D LH +G + + +LHG + +
Sbjct: 71 LIGWRRFGQARPNDAHHALARLEANGRCGMLLTQNVDRLHQSAG--HRQVIDLHGRLDLV 128
Query: 140 ECNICKRQFVRSSPVETVGK 159
C C + RS +T+G+
Sbjct: 129 RCMGCGAKTPRSEFQDTLGR 148
>UniRef50_Q1D9X2 Cluster: Sir2 family protein; n=1; Myxococcus
xanthus DK 1622|Rep: Sir2 family protein - Myxococcus
xanthus (strain DK 1622)
Length = 287
Score = 46.4 bits (105), Expect = 0.001
Identities = 36/122 (29%), Positives = 50/122 (40%), Gaps = 19/122 (15%)
Query: 48 VVHTGAGISTSAGIPDFRGPNGVWTLEKEGK------KPTINVS-----------FADAQ 90
VV TGAG ST +GIPD+RGP + +P + F+ A+
Sbjct: 30 VVLTGAGCSTESGIPDYRGPGTRARARNPIQHREFLTRPEVRARYWARSLMGWPRFSSAR 89
Query: 91 PTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNICKRQFVR 150
P H ++QN+DGLH +G R + ELHG + C C Q R
Sbjct: 90 PNAAHAALAELEQAGHVRGLITQNVDGLHHAAGSSR--VIELHGALAQVRCLACGAQEAR 147
Query: 151 SS 152
+
Sbjct: 148 EA 149
>UniRef50_Q23A43 Cluster: Transcriptional regulator, Sir2 family
protein; n=2; Tetrahymena thermophila SB210|Rep:
Transcriptional regulator, Sir2 family protein -
Tetrahymena thermophila SB210
Length = 503
Score = 46.4 bits (105), Expect = 0.001
Identities = 22/40 (55%), Positives = 26/40 (65%)
Query: 38 AQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEG 77
AQL KD K +V TGAGIS ++GIP FRG EK+G
Sbjct: 118 AQLFKDKKKVVFLTGAGISVASGIPTFRGVGAAPLFEKDG 157
>UniRef50_Q1RPU3 Cluster: Zinc finger protein; n=1; Ciona
intestinalis|Rep: Zinc finger protein - Ciona
intestinalis (Transparent sea squirt)
Length = 737
Score = 46.4 bits (105), Expect = 0.001
Identities = 23/56 (41%), Positives = 36/56 (64%), Gaps = 1/56 (1%)
Query: 17 ILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT 72
I+ P++ D +N + +L+K SK I+V TGAG+S S GIPDFR +G+++
Sbjct: 162 IISEPKRRKKLDTVNTLSDAI-RLIKTSKKILVLTGAGVSVSCGIPDFRSRDGIYS 216
>UniRef50_A0D0F1 Cluster: Chromosome undetermined scaffold_33, whole
genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_33,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 264
Score = 46.4 bits (105), Expect = 0.001
Identities = 32/135 (23%), Positives = 55/135 (40%), Gaps = 23/135 (17%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTL-----EKEGKKPTINVSFADAQP 91
+ + +K+ + ++ GAG+ +G+PDFRG G WT+ K G N SF D P
Sbjct: 1 MQKYIKECQAFIITAGAGMGVDSGLPDFRGNKGFWTVYRPFENKFGFTDCANPSFMDYNP 60
Query: 92 T--------KTHMXXXX----------XXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELH 133
+ HM ++ N+DG K+G + E+H
Sbjct: 61 NLFWGFYGHRLHMYRNAVPHDGFQILKKIFQNRDYFVITSNVDGQFQKAGFDSNHIYEMH 120
Query: 134 GNMFIDECNICKRQF 148
G++ +C C + +
Sbjct: 121 GSIHKFQCTPCDKLY 135
>UniRef50_UPI0000D578DC Cluster: PREDICTED: similar to sirtuin 5
(silent mating type information regulation 2 homolog) 5;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
sirtuin 5 (silent mating type information regulation 2
homolog) 5 - Tribolium castaneum
Length = 254
Score = 46.0 bits (104), Expect = 0.002
Identities = 37/130 (28%), Positives = 60/130 (46%), Gaps = 25/130 (19%)
Query: 39 QLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEK--EGKKPTI-------------- 82
++V ++ IV TGAG+S +GIP FRG G+W + + PT
Sbjct: 14 RVVSQARSIVALTGAGVSAESGIPVFRGAGGLWRTHRATDLATPTAFRANPALVWEFYHY 73
Query: 83 --NVSFADAQPTKTHMXXXXX----XXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNM 136
+V+F ++QP H ++QN+DGLH ++G + + ELHG++
Sbjct: 74 RRDVAF-NSQPNNAHKALAKYEKICKEQGRQFHVITQNVDGLHKRAG--SENVLELHGSL 130
Query: 137 FIDECNICKR 146
C CK+
Sbjct: 131 DKVICTKCKQ 140
>UniRef50_A6DES9 Cluster: Transcriptional regulator, Sir2 family
protein; n=2; Epsilonproteobacteria|Rep:
Transcriptional regulator, Sir2 family protein -
Caminibacter mediatlanticus TB-2
Length = 264
Score = 46.0 bits (104), Expect = 0.002
Identities = 22/57 (38%), Positives = 33/57 (57%), Gaps = 1/57 (1%)
Query: 36 LLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSFADAQPT 92
L A +K++K++++ GAG+ +G+PDFRG G W KK +N A A PT
Sbjct: 6 LAANEIKNAKYLLITAGAGMGVDSGLPDFRGNEGFWRAYPIAKKLGLNFQ-ALANPT 61
>UniRef50_A3JEV2 Cluster: NAD-dependent deacetylase; n=2;
Marinobacter|Rep: NAD-dependent deacetylase -
Marinobacter sp. ELB17
Length = 300
Score = 46.0 bits (104), Expect = 0.002
Identities = 34/136 (25%), Positives = 56/136 (41%), Gaps = 19/136 (13%)
Query: 32 QKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVS------ 85
Q +LA + +++ TGAG+ST +GIPD+R +G W ++ + S
Sbjct: 31 QAGAMLADYIHSHPRLLILTGAGVSTDSGIPDYRDGDGAWKRKQPVQHQAFMGSVQTRQR 90
Query: 86 -----------FADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHG 134
+A P +H V+QN+D LH K+G + + +LHG
Sbjct: 91 YWGRSLIGWPLMRNASPNASHHHISQLEMLNHSSLVVTQNVDRLHQKAGT--QAVTDLHG 148
Query: 135 NMFIDECNICKRQFVR 150
C C + +R
Sbjct: 149 RADEVLCMSCDYRCMR 164
>UniRef50_A0PU12 Cluster: Sir2-like regulatory protein; n=1;
Mycobacterium ulcerans Agy99|Rep: Sir2-like regulatory
protein - Mycobacterium ulcerans (strain Agy99)
Length = 283
Score = 46.0 bits (104), Expect = 0.002
Identities = 36/121 (29%), Positives = 48/121 (39%), Gaps = 17/121 (14%)
Query: 47 IVVHTGAGISTSAGIPDFRGPNGV----WTLEKEGKKPTINVSF-----------ADAQP 91
I V TGAGIST +GIPD+RGP+ T+ + P + D P
Sbjct: 15 IAVLTGAGISTDSGIPDYRGPDSPPSNPMTIRQFTSDPVFRQRYWARNHVGWRHMDDTAP 74
Query: 92 TKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNICKRQFVRS 151
H ++QN+D LH K+G K + LHG C C RS
Sbjct: 75 NAGHRALAALERAGVVTGVITQNVDLLHTKAG--SKNVVNLHGTYAQVTCLGCGHTISRS 132
Query: 152 S 152
+
Sbjct: 133 T 133
>UniRef50_Q2GZ88 Cluster: Putative uncharacterized protein; n=1;
Chaetomium globosum|Rep: Putative uncharacterized
protein - Chaetomium globosum (Soil fungus)
Length = 895
Score = 46.0 bits (104), Expect = 0.002
Identities = 20/37 (54%), Positives = 29/37 (78%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTL 73
+A + S+ +VV TGAGIST++GIPDFR NG+++L
Sbjct: 17 IANTLWKSRKVVVITGAGISTNSGIPDFRSENGLYSL 53
>UniRef50_Q9Y6E7 Cluster: NAD-dependent deacetylase sirtuin-4; n=23;
Deuterostomia|Rep: NAD-dependent deacetylase sirtuin-4 -
Homo sapiens (Human)
Length = 314
Score = 46.0 bits (104), Expect = 0.002
Identities = 42/140 (30%), Positives = 57/140 (40%), Gaps = 24/140 (17%)
Query: 32 QKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTIN-------- 83
+K L + + SK ++V TGAGIST +GIPD+R V + ++P +
Sbjct: 42 EKVKELQRFITLSKRLLVMTGAGISTESGIPDYRSEK-VGLYARTDRRPIQHGDFVRSAP 100
Query: 84 -------------VSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLA 130
F+ QP H V+QN+D LH K+G R L
Sbjct: 101 IRQRYWARNFVGWPQFSSHQPNPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRR--LT 158
Query: 131 ELHGNMFIDECNICKRQFVR 150
ELHG M C C Q R
Sbjct: 159 ELHGCMDRVLCLDCGEQTPR 178
>UniRef50_Q5BVF7 Cluster: SJCHGC03105 protein; n=2; Schistosoma
japonicum|Rep: SJCHGC03105 protein - Schistosoma
japonicum (Blood fluke)
Length = 181
Score = 45.6 bits (103), Expect = 0.002
Identities = 26/54 (48%), Positives = 35/54 (64%), Gaps = 3/54 (5%)
Query: 37 LAQLVKDSK--HIVVHTGAGISTSAGIPDFRGP-NGVWTLEKEGKKPTINVSFA 87
++QL++D K IV GAGIST+AGIPDFR P +GV+ +E PT F+
Sbjct: 52 VSQLIQDGKINKIVTMVGAGISTAAGIPDFRSPSSGVYDNLEEFNLPTPTTIFS 105
>UniRef50_Q4WET3 Cluster: SIR2 family histone deacetylase, putative;
n=4; Pezizomycotina|Rep: SIR2 family histone
deacetylase, putative - Aspergillus fumigatus (Sartorya
fumigata)
Length = 381
Score = 45.6 bits (103), Expect = 0.002
Identities = 36/124 (29%), Positives = 50/124 (40%), Gaps = 21/124 (16%)
Query: 48 VVHTGAGISTSAGIPDFRGPNGVWTLEK--------------EGKKPTINVSFAD----- 88
V+ TGAGIS ++G+ D+RG G + K E +K SF
Sbjct: 58 VLLTGAGISVASGLSDYRGEKGTYVTNKFYRPIYFHEFLSRHESRKRYWARSFVGWPGLL 117
Query: 89 -AQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNICKRQ 147
A+P TH V+QN+D H P ELHG++ C C+ Q
Sbjct: 118 KAEPNSTHWAIRDLAAKGFVSSVVTQNVDSFH-SIAHPELPTIELHGHLKSVVCTSCRNQ 176
Query: 148 FVRS 151
F R+
Sbjct: 177 FSRA 180
>UniRef50_UPI0000D55B5A Cluster: PREDICTED: similar to CG5216-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG5216-PA - Tribolium castaneum
Length = 722
Score = 44.8 bits (101), Expect = 0.004
Identities = 18/35 (51%), Positives = 28/35 (80%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 71
+ +LVK +++I+V TGAG+S S GIPDFR +G++
Sbjct: 204 VVRLVKGAQNIIVLTGAGVSVSCGIPDFRSRDGIY 238
>UniRef50_UPI000051AA14 Cluster: PREDICTED: similar to NAD-dependent
deacetylase sirtuin-1 (hSIRT1) (hSIR2) (SIR2-like
protein 1); n=1; Apis mellifera|Rep: PREDICTED: similar
to NAD-dependent deacetylase sirtuin-1 (hSIRT1) (hSIR2)
(SIR2-like protein 1) - Apis mellifera
Length = 868
Score = 44.8 bits (101), Expect = 0.004
Identities = 17/36 (47%), Positives = 28/36 (77%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT 72
+ +L+++S I+V TGAG+S S GIPDFR +G+++
Sbjct: 196 VVRLIRNSNRIIVLTGAGVSVSCGIPDFRSRDGIYS 231
>UniRef50_Q1YSP9 Cluster: NAD-dependent deacetylase; n=1; gamma
proteobacterium HTCC2207|Rep: NAD-dependent deacetylase
- gamma proteobacterium HTCC2207
Length = 270
Score = 44.8 bits (101), Expect = 0.004
Identities = 33/135 (24%), Positives = 58/135 (42%), Gaps = 20/135 (14%)
Query: 39 QLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW----------------TLEKEGKKPTI 82
+L+ +V TGAG+S +G+P +R G W ++ + +
Sbjct: 6 RLLNSKARWLVLTGAGVSAESGVPTYRNQRGEWQRKPPVTHQEFTGNHQARQRFWARNLV 65
Query: 83 NVSF-ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDEC 141
F + A+P H V+QN+DGLH ++G + + +LHG + C
Sbjct: 66 GWRFMSSARPNGAHSALASLEKAGAVSCLVTQNVDGLHQRAGSQK--VIDLHGRVDSVSC 123
Query: 142 NICKRQFVRSSPVET 156
CK + R +P++T
Sbjct: 124 LSCKLRLPR-APLQT 137
>UniRef50_Q03ZB1 Cluster: NAD-dependent protein deacetylase, SIR2
family; n=3; Leuconostocaceae|Rep: NAD-dependent protein
deacetylase, SIR2 family - Leuconostoc mesenteroides
subsp. mesenteroides (strain ATCC 8293 /NCDO 523)
Length = 234
Score = 44.8 bits (101), Expect = 0.004
Identities = 31/113 (27%), Positives = 52/113 (46%), Gaps = 19/113 (16%)
Query: 43 DSKHIVVHTGAGISTSAGIPDFRGPNGVW------------------TLEKEGKKPTINV 84
++K+IV TGAG+ST +GIPD+R G++ EK+ + N+
Sbjct: 13 NAKNIVFMTGAGVSTLSGIPDYRSKGGIYDGISLQPEYLLSATAFHNEPEKQYQFMIDNM 72
Query: 85 SFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMF 137
F +A P H ++QN+D LH+K+ + L HG+++
Sbjct: 73 YFPEAVPNVIH-KKMAALTRQGKAKIITQNVDDLHVKAASDPEKLIRFHGSLY 124
>UniRef50_Q7S386 Cluster: Putative uncharacterized protein
NCU04859.1; n=1; Neurospora crassa|Rep: Putative
uncharacterized protein NCU04859.1 - Neurospora crassa
Length = 1327
Score = 44.8 bits (101), Expect = 0.004
Identities = 19/37 (51%), Positives = 29/37 (78%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTL 73
+A + ++ +VV TGAGIST++GIPDFR NG+++L
Sbjct: 17 IANSLYKARKVVVITGAGISTNSGIPDFRSENGLYSL 53
>UniRef50_Q6CB00 Cluster: Similarities with tr|Q9UR39
Schizosaccharomyces pombe HST4P; n=1; Yarrowia
lipolytica|Rep: Similarities with tr|Q9UR39
Schizosaccharomyces pombe HST4P - Yarrowia lipolytica
(Candida lipolytica)
Length = 721
Score = 44.8 bits (101), Expect = 0.004
Identities = 27/65 (41%), Positives = 39/65 (60%), Gaps = 2/65 (3%)
Query: 27 NDKLNQKCV-LLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW-TLEKEGKKPTINV 84
N +N+K + LL + +S+ +VV TGAGIS AGIPDFR G++ +L+ E T
Sbjct: 157 NSDINRKDLELLHHVFHNSQRLVVITGAGISVHAGIPDFRSDKGLFVSLKDEYNLKTTGK 216
Query: 85 SFADA 89
+ DA
Sbjct: 217 ALFDA 221
>UniRef50_A6RSV6 Cluster: Putative uncharacterized protein; n=2;
Sclerotiniaceae|Rep: Putative uncharacterized protein -
Botryotinia fuckeliana B05.10
Length = 1195
Score = 44.8 bits (101), Expect = 0.004
Identities = 18/37 (48%), Positives = 29/37 (78%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTL 73
+A ++ S+ +VV TGAGIST+ GIPDFR +G++++
Sbjct: 17 IADILAKSRKVVVVTGAGISTNVGIPDFRSEHGLYSM 53
>UniRef50_A7RMK8 Cluster: Predicted protein; n=5; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 273
Score = 44.4 bits (100), Expect = 0.005
Identities = 39/127 (30%), Positives = 53/127 (41%), Gaps = 23/127 (18%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW------TLEKEG---KKPTINVSF- 86
L L+ +K+I+ TGAGIS +GIP FRG G+W L G P++ F
Sbjct: 18 LKDLLSKAKNILFLTGAGISAESGIPTFRGAGGLWRTFSATDLATPGAFHTNPSLVWEFY 77
Query: 87 -------ADAQPTKTHMXXXXXXXXXXXXX----XVSQNIDGLHLKSGVPRKFLAELHGN 135
+P H V+QNID LH +G + + ELHG
Sbjct: 78 SYRREVVLSKKPNPAHFAIAEFQKKMRNEGKQVWVVTQNIDELHKTAGA--EDVIELHGT 135
Query: 136 MFIDECN 142
+F CN
Sbjct: 136 LFKTRCN 142
>UniRef50_Q6CQA7 Cluster: Kluyveromyces lactis strain NRRL Y-1140
chromosome D of strain NRRL Y- 1140 of Kluyveromyces
lactis; n=1; Kluyveromyces lactis|Rep: Kluyveromyces
lactis strain NRRL Y-1140 chromosome D of strain NRRL Y-
1140 of Kluyveromyces lactis - Kluyveromyces lactis
(Yeast) (Candida sphaerica)
Length = 399
Score = 44.4 bits (100), Expect = 0.005
Identities = 21/39 (53%), Positives = 27/39 (69%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEK 75
L ++ SK IVV GAG+S +AGIPDFR NG++T K
Sbjct: 105 LTYVLSYSKRIVVVQGAGVSVAAGIPDFRSANGLFTTLK 143
>UniRef50_A7TQE2 Cluster: Putative uncharacterized protein; n=1;
Vanderwaltozyma polyspora DSM 70294|Rep: Putative
uncharacterized protein - Vanderwaltozyma polyspora DSM
70294
Length = 602
Score = 44.4 bits (100), Expect = 0.005
Identities = 35/125 (28%), Positives = 54/125 (43%), Gaps = 21/125 (16%)
Query: 41 VKDSKHIVVHTGAGISTSAGIPDFRG---------------PNGVWTLEKEGKKPTI--N 83
+K +K I+V TGAGISTS GIPDFR P V+ L+ + P++ N
Sbjct: 263 LKSAKKIIVLTGAGISTSLGIPDFRSSEGFYSKLRNLGLDDPQDVFNLQIFRENPSVFYN 322
Query: 84 VSFADAQP----TKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFID 139
+++ P + H +QNID L +G+ + + + HG+
Sbjct: 323 IAYMVLPPENIFSPLHSFLKLLQDKDKLLRNYTQNIDNLESYAGIKPEKMVQCHGSFATA 382
Query: 140 ECNIC 144
C C
Sbjct: 383 SCFSC 387
Score = 33.9 bits (74), Expect = 6.8
Identities = 20/73 (27%), Positives = 38/73 (52%), Gaps = 4/73 (5%)
Query: 207 DLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYYVDDVLEKVMD 266
DL IC+GT+L++ P ++ + + ++ N P +H N DL + Y DD+ +
Sbjct: 509 DLLICIGTSLKVSPVSDI-VNMVPQHVPQILINKDPIRHCN-FDLSLLGYCDDIAAYISK 566
Query: 267 ILG--IEIPSYNE 277
+ I+ P +N+
Sbjct: 567 LCDWKIDHPKWND 579
>UniRef50_Q8IXJ6 Cluster: NAD-dependent deacetylase sirtuin-2; n=31;
Coelomata|Rep: NAD-dependent deacetylase sirtuin-2 -
Homo sapiens (Human)
Length = 389
Score = 44.4 bits (100), Expect = 0.005
Identities = 50/204 (24%), Positives = 83/204 (40%), Gaps = 32/204 (15%)
Query: 45 KHIVVHTGAGISTSAGIPDFRGPN-GVW-TLEK---EGKKPTINVSF------------- 86
+ ++ GAGISTSAGIPDFR P+ G++ LEK + +S+
Sbjct: 77 RRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAK 136
Query: 87 ----ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDEC- 141
+PT H +QNID L +G+ ++ L E HG + C
Sbjct: 137 ELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCV 196
Query: 142 -NICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAE 200
C+ ++ S E + + + C C+ + ++ + SLP +
Sbjct: 197 SASCRHEYPLSWMKEKIFSEVT-PKC-------EDCQSLVKPDIVFFGESLPARFFSCMQ 248
Query: 201 WHSSIADLSICLGTTLQIVPSGNL 224
DL + +GT+LQ+ P +L
Sbjct: 249 SDFLKVDLLLVMGTSLQVQPFASL 272
>UniRef50_UPI000023F1DF Cluster: hypothetical protein FG02466.1;
n=1; Gibberella zeae PH-1|Rep: hypothetical protein
FG02466.1 - Gibberella zeae PH-1
Length = 1569
Score = 44.0 bits (99), Expect = 0.006
Identities = 22/34 (64%), Positives = 28/34 (82%), Gaps = 1/34 (2%)
Query: 40 LVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTL 73
L+K K IVV TGAGIST++GIPDFR NG+++L
Sbjct: 638 LLKARKVIVV-TGAGISTNSGIPDFRSENGLYSL 670
>UniRef50_A4JS80 Cluster: Silent information regulator protein
Sir2; n=1; Burkholderia vietnamiensis G4|Rep: Silent
information regulator protein Sir2 - Burkholderia
vietnamiensis (strain G4 / LMG 22486)
(Burkholderiacepacia (strain R1808))
Length = 274
Score = 44.0 bits (99), Expect = 0.006
Identities = 17/35 (48%), Positives = 24/35 (68%)
Query: 38 AQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT 72
A + D+ IV+ GAG+S +G+PDFRG G+WT
Sbjct: 11 ADWIADADGIVIAAGAGMSVDSGLPDFRGTGGLWT 45
>UniRef50_Q7R0G2 Cluster: GLP_29_33086_34261; n=1; Giardia lamblia
ATCC 50803|Rep: GLP_29_33086_34261 - Giardia lamblia
ATCC 50803
Length = 391
Score = 44.0 bits (99), Expect = 0.006
Identities = 37/145 (25%), Positives = 65/145 (44%), Gaps = 22/145 (15%)
Query: 18 LGVPEKFDSNDKLNQKCVL-LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPN-GVWT--L 73
+G P S + +L LA+ ++ + ++ TGAG+S ++GI +R N +W+ +
Sbjct: 31 VGSPTAAASKSGTSLNAILQLARTLRAGRAVIFVTGAGLSYASGITPYRYSNKAIWSNFV 90
Query: 74 EKEGKKPTINV-----------------SFADAQPTKTHMXXXXXXXXXXXXXXVSQNID 116
G++ T SF +A+P + H+ ++QNID
Sbjct: 91 MASGERRTFKEDPDQYWNSFWLRTHEIPSFINAKPNQGHIAIAKIMRKADVFV-ITQNID 149
Query: 117 GLHLKSGVPRKFLAELHGNMFIDEC 141
LH KSG L E+HG + + +C
Sbjct: 150 TLHTKSGALENRLVEIHGRLGLYKC 174
>UniRef50_Q54P49 Cluster: Zn finger-containing protein; n=1;
Dictyostelium discoideum AX4|Rep: Zn finger-containing
protein - Dictyostelium discoideum AX4
Length = 456
Score = 44.0 bits (99), Expect = 0.006
Identities = 46/191 (24%), Positives = 79/191 (41%), Gaps = 37/191 (19%)
Query: 13 ENKGILGVPEKFDSNDKL-NQKCVLLAQLVKDSK--HIVVHTGAGISTSAGIPDFRG-PN 68
+N I+ K ++ ++ N K +L+K+ K +I+V TGAGIS ++GIPDFR
Sbjct: 146 KNSNIIKNEIKIENEIEIENNKIKEFIKLIKNDKCKNIIVLTGAGISVASGIPDFRSVET 205
Query: 69 GVWTLEKEG------KKPTINVSFADAQP------------------TKTHMXXXXXXXX 104
G++ E K+ ++ + P T H
Sbjct: 206 GLYNNENVSKFKLPFKEAVFDIDYFKFNPEPFYQLSKDLYPSGKFKCTPVHYFIKLLSDK 265
Query: 105 XXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNIC----KRQFVRSS-----PVE 155
+QN D L +G+P L E HG+ + C C +++++ S P++
Sbjct: 266 GLLLRNYAQNADTLERIAGIPLDKLIEAHGSFAVSRCTNCGLEYSQEYIKDSIFNNDPLK 325
Query: 156 TVGKKCSGVPC 166
+V +C V C
Sbjct: 326 SVVPRCKVVQC 336
>UniRef50_A7RLD5 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 335
Score = 44.0 bits (99), Expect = 0.006
Identities = 50/208 (24%), Positives = 79/208 (37%), Gaps = 29/208 (13%)
Query: 52 GAGISTSAGIPDFRGPN-GVWTLEKEGKKPTINVSF---------------------ADA 89
GAGIST +GIPDFR P G++ +E P F +
Sbjct: 3 GAGISTPSGIPDFRTPGTGLYDNLQEYNIPEPTAIFDIEYFWYDPRPFFCLAKTLYPGNY 62
Query: 90 QPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNICKRQFV 149
QP H +QNIDGL +G+P + L E HG C C +
Sbjct: 63 QPNYVHYFVKLLHDKGFLLRMYTQNIDGLERLAGLPAEKLVEAHGTFSTASCISCHHSYD 122
Query: 150 RSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAEWHSSIADLS 209
+T+ + +P C+G + V+ + LP+ E DL
Sbjct: 123 GEQIRKTI--ENGDIP----RCETIKCKGVIKPDVVFFGEDLPKR-FYSFEIDFRKCDLL 175
Query: 210 ICLGTTLQIVPSGNLPLETIKYGGKLVI 237
+ +GT+L++ P + E + +++I
Sbjct: 176 LVMGTSLEVEPFAGIVNEVSRSTPRVLI 203
>UniRef50_Q4WT50 Cluster: SIR2 family histone deacetylase (Hst4),
putative; n=7; Trichocomaceae|Rep: SIR2 family histone
deacetylase (Hst4), putative - Aspergillus fumigatus
(Sartorya fumigata)
Length = 614
Score = 44.0 bits (99), Expect = 0.006
Identities = 22/42 (52%), Positives = 32/42 (76%), Gaps = 1/42 (2%)
Query: 36 LLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW-TLEKE 76
LL + ++ + IVV GAGISTSAGIPDFR +G++ +L+K+
Sbjct: 125 LLVKTLRRHRKIVVIAGAGISTSAGIPDFRSTDGLFKSLQKK 166
>UniRef50_P53688 Cluster: NAD-dependent histone deacetylase HST4;
n=5; Saccharomycetales|Rep: NAD-dependent histone
deacetylase HST4 - Saccharomyces cerevisiae (Baker's
yeast)
Length = 370
Score = 44.0 bits (99), Expect = 0.006
Identities = 41/133 (30%), Positives = 57/133 (42%), Gaps = 32/133 (24%)
Query: 44 SKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGK------------KPTINVSF----- 86
SK +VV +GAGIS +AGIPDFR G+++ G ++++ F
Sbjct: 92 SKRMVVVSGAGISVAAGIPDFRSSEGIFSTVNGGSGKDLFDYNRVYGDESMSLKFNQLMV 151
Query: 87 ------ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGL-----HLKSGVPR----KFLAE 131
+ QPTK H +QNIDGL HL + VP +
Sbjct: 152 SLFRLSKNCQPTKFHEMLNEFARDGRLLRLYTQNIDGLDTQLPHLSTNVPLAKPIPSTVQ 211
Query: 132 LHGNMFIDECNIC 144
LHG++ ECN C
Sbjct: 212 LHGSIKHMECNKC 224
>UniRef50_Q4APN6 Cluster: Silent information regulator protein Sir2;
n=1; Chlorobium phaeobacteroides BS1|Rep: Silent
information regulator protein Sir2 - Chlorobium
phaeobacteroides BS1
Length = 217
Score = 43.6 bits (98), Expect = 0.008
Identities = 33/111 (29%), Positives = 49/111 (44%), Gaps = 23/111 (20%)
Query: 51 TGAGISTSAGIPDFRGPNGVW---------TLEKEGKKPTINVSF--------ADAQPTK 93
TGAG+S +G+P +RG G+W E + P + F D QP +
Sbjct: 4 TGAGMSAESGVPTYRGKGGIWGSYSIDEYACQEAFDRNPEKVLGFHEKRRKSVLDCQPHE 63
Query: 94 THMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNIC 144
H V+QNIDG+H ++G K + ELHG+++ C C
Sbjct: 64 GH----SVVAVLPNAKVVTQNIDGMHQRAG--SKDVIELHGSLWRLRCQSC 108
>UniRef50_Q7PS76 Cluster: ENSANGP00000025231; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000025231 - Anopheles gambiae
str. PEST
Length = 182
Score = 43.6 bits (98), Expect = 0.008
Identities = 37/114 (32%), Positives = 50/114 (43%), Gaps = 24/114 (21%)
Query: 47 IVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSFADAQPTK------------- 93
I+V TGAGIST +GIPD+R GV + KP + F ++ T+
Sbjct: 1 ILVLTGAGISTESGIPDYRS-EGVGLYARSNHKPIQHGDFVKSEATRKRYWARNYVGWPK 59
Query: 94 --------THMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFID 139
TH V+QN+D LH K+G K + ELHG+ F D
Sbjct: 60 FSSIAPNVTHYTLARLEREGRISGIVTQNVDRLHGKAG--SKQVIELHGSGFDD 111
>UniRef50_Q7ZVK3 Cluster: NAD-dependent deacetylase sirtuin-2; n=12;
Coelomata|Rep: NAD-dependent deacetylase sirtuin-2 -
Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 379
Score = 43.6 bits (98), Expect = 0.008
Identities = 59/241 (24%), Positives = 93/241 (38%), Gaps = 35/241 (14%)
Query: 28 DKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRG----------------PNGVW 71
D+L V L K+I+ GAGISTSAGIPDFR P ++
Sbjct: 58 DELTLDSVARYILSGKCKNIICMVGAGISTSAGIPDFRSPGTGLYANLQKYNLPYPEAIF 117
Query: 72 TLEKEGKKPTINVSFA------DAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVP 125
++ K P + A +PT H SQNID L +G+
Sbjct: 118 QIDYFKKHPEPFFALARELYPGQFKPTVYHYFIKMLKDKGLLRRCYSQNIDTLERVAGLE 177
Query: 126 RKFLAELHGNMFIDEC--NICKRQFVRSSPVETVGKKCSGVP-CAAHHVTGRPCRGRLYD 182
+ L E HG C +C++++ + + +P C + C +
Sbjct: 178 GEDLIEAHGTFHTSHCVSFLCRKEYSMDWMKNQIFSE--EIPKCDS-------CGSLVKP 228
Query: 183 GVLDWEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQP 242
++ + SLP + DL I +GT+LQ+ P +L +L+I N++
Sbjct: 229 DIVFFGESLPSRFFTSMKADFPQCDLLIIMGTSLQVQPFASLVSRVSNRCPRLLI-NMEK 287
Query: 243 T 243
T
Sbjct: 288 T 288
>UniRef50_Q9RL35 Cluster: NAD-dependent deacetylase 1; n=8;
Actinomycetales|Rep: NAD-dependent deacetylase 1 -
Streptomyces coelicolor
Length = 299
Score = 43.6 bits (98), Expect = 0.008
Identities = 34/115 (29%), Positives = 51/115 (44%), Gaps = 19/115 (16%)
Query: 47 IVVHTGAGISTSAGIPDFRGPNGV-----------WTLEKEGKKPTINVS------FADA 89
++V +GAGIST +GIPD+RG G +T E ++ S F A
Sbjct: 34 VLVLSGAGISTESGIPDYRGEGGSLSRHTPMTYQDFTAHPEARRRYWARSHLGWRTFGRA 93
Query: 90 QPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNIC 144
+P H ++QN+DGLH +G + + ELHG++ C C
Sbjct: 94 RPNAGHRSVAAFGRHGLLTGVITQNVDGLHQAAG--SEGVVELHGSLDRVVCLSC 146
>UniRef50_Q1QTH0 Cluster: Silent information regulator protein Sir2;
n=2; Oceanospirillales|Rep: Silent information regulator
protein Sir2 - Chromohalobacter salexigens (strain DSM
3043 / ATCC BAA-138 / NCIMB13768)
Length = 242
Score = 43.2 bits (97), Expect = 0.011
Identities = 32/110 (29%), Positives = 48/110 (43%), Gaps = 19/110 (17%)
Query: 46 HIVVHTGAGISTSAGIPDFRGPNGVW---------TLEKEGKKPTINVSFADAQ------ 90
H+VV TGAGIS +G+ FR +G+W T E + P + F DA+
Sbjct: 8 HLVVLTGAGISAESGLKTFRDGDGLWENHRVQDVATPEAFARDPETVLRFYDARREQTRQ 67
Query: 91 --PTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFI 138
P H ++QNID LH ++G + + LHG + +
Sbjct: 68 ATPNAAHRALAELEQAGFQVSVITQNIDDLHERAG--SRDVLHLHGEILM 115
>UniRef50_A4A8B4 Cluster: Silent information regulator protein Sir2;
n=1; Congregibacter litoralis KT71|Rep: Silent
information regulator protein Sir2 - Congregibacter
litoralis KT71
Length = 297
Score = 43.2 bits (97), Expect = 0.011
Identities = 37/133 (27%), Positives = 55/133 (41%), Gaps = 20/133 (15%)
Query: 30 LNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKE------------- 76
L+ + L+ L+ D ++V TGAGIS S GIP +R G W
Sbjct: 7 LHAESDFLSALI-DHAPVLVITGAGISVSTGIPTYRDEKGAWLRSNPITHQEFVADRRQR 65
Query: 77 ----GKKPTINVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAEL 132
G+ + DA+P K H V+QN+D LH ++G R + +L
Sbjct: 66 QRYWGRSLLGWPAVRDAKPAKGHRLLAQLEHHGLVSHIVTQNVDRLHQRAGSIR--VTDL 123
Query: 133 HGNMFIDECNICK 145
HG + C C+
Sbjct: 124 HGRLDRVRCLGCE 136
>UniRef50_Q0UMU7 Cluster: Putative uncharacterized protein; n=1;
Phaeosphaeria nodorum|Rep: Putative uncharacterized
protein - Phaeosphaeria nodorum (Septoria nodorum)
Length = 670
Score = 42.7 bits (96), Expect = 0.015
Identities = 24/54 (44%), Positives = 32/54 (59%), Gaps = 1/54 (1%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW-TLEKEGKKPTINVSFADA 89
L ++ + IVV GAGIS SAGIPDFR G++ +L+KE K + DA
Sbjct: 117 LLNVLHKKRKIVVIAGAGISVSAGIPDFRSATGLFNSLKKEHKLKSSGKDLFDA 170
>UniRef50_Q882K4 Cluster: NAD-dependent deacetylase 3; n=5;
Pseudomonas|Rep: NAD-dependent deacetylase 3 -
Pseudomonas syringae pv. tomato
Length = 281
Score = 42.7 bits (96), Expect = 0.015
Identities = 43/170 (25%), Positives = 71/170 (41%), Gaps = 29/170 (17%)
Query: 45 KHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSF------------------ 86
K +V TGAGIST++GIPD+R +GV + G +P + F
Sbjct: 20 KSFLVVTGAGISTASGIPDYRDKDGV----RRGAQPMMYQEFVGNPAARQRYWARAMLGW 75
Query: 87 ---ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNI 143
+ +Q H ++QN+D LH ++G + + ELHG++ C
Sbjct: 76 PRISASQANAAHRALAALQAENLIKGLITQNVDALHTQAG--SQDVIELHGSLHRVLCLD 133
Query: 144 CKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPE 193
C+++ R++ E + + A H T P L D + +PE
Sbjct: 134 CQQRSDRTAIQEQM--LAHNLYLADVHATQAPDGDTLLDPAYEAGFKVPE 181
>UniRef50_Q9UR39 Cluster: NAD-dependent deacetylase hst4; n=1;
Schizosaccharomyces pombe|Rep: NAD-dependent
deacetylase hst4 - Schizosaccharomyces pombe (Fission
yeast)
Length = 415
Score = 42.7 bits (96), Expect = 0.015
Identities = 19/36 (52%), Positives = 25/36 (69%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT 72
L ++ +K IVV TGAGIS AGIPDFR G+++
Sbjct: 50 LVSAIRKAKRIVVVTGAGISCDAGIPDFRSSEGLFS 85
>UniRef50_Q0LFI4 Cluster: Silent information regulator protein Sir2;
n=1; Herpetosiphon aurantiacus ATCC 23779|Rep: Silent
information regulator protein Sir2 - Herpetosiphon
aurantiacus ATCC 23779
Length = 171
Score = 42.3 bits (95), Expect = 0.019
Identities = 40/156 (25%), Positives = 65/156 (41%), Gaps = 15/156 (9%)
Query: 88 DAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNICKRQ 147
D QP H+ ++QNIDGLH ++G R + ELHG + C+ +
Sbjct: 3 DVQPNAGHVALAQLEQHIPSVTIITQNIDGLHQRAGSTR--VIELHGTINTVSCSAAEHG 60
Query: 148 FVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAEWHSSIAD 207
+ + P CS CAA P R V+ + L + AE S D
Sbjct: 61 SL-AWPDSPNLPFCS--VCAA------PLR----PDVVWFGERLDLAKIQAAELASQTCD 107
Query: 208 LSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPT 243
+ + +GT+ + P+ P+ + +L+ NL+ T
Sbjct: 108 VFLAIGTSGVVAPAATFPMTARAHRARLIDLNLEDT 143
>UniRef50_Q6C8V5 Cluster: Similar to tr|Q9FY91 Arabidopsis
thaliana SIR2-family protein; n=1; Yarrowia
lipolytica|Rep: Similar to tr|Q9FY91 Arabidopsis
thaliana SIR2-family protein - Yarrowia lipolytica
(Candida lipolytica)
Length = 411
Score = 42.3 bits (95), Expect = 0.019
Identities = 20/45 (44%), Positives = 31/45 (68%), Gaps = 2/45 (4%)
Query: 42 KDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSF 86
K++K ++ TGAGIST++G+PD+RGP G +T +PT+ F
Sbjct: 46 KNTKTAIL-TGAGISTASGLPDYRGPTGTYT-TNPNHQPTLYHEF 88
Score = 34.3 bits (75), Expect = 5.2
Identities = 25/92 (27%), Positives = 44/92 (47%), Gaps = 3/92 (3%)
Query: 176 CRGRLYDGVLDWEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKL 235
C G L ++ + S+PE D A +D + +GT+L + +L + K G K+
Sbjct: 318 CGGVLKPSIVFFGESVPEADRARARDLLESSDQLLVIGTSLSTFSAFDLVRQFYKQGKKV 377
Query: 236 VICNLQPTKHDNK---ADLLINYYVDDVLEKV 264
+ N + + K AD+ ++ + VLEKV
Sbjct: 378 AVLNKGGVRGEGKDWEADVRLDGDIGGVLEKV 409
>UniRef50_Q6BPA4 Cluster: Debaryomyces hansenii chromosome E of
strain CBS767 of Debaryomyces hansenii; n=6;
Saccharomycetales|Rep: Debaryomyces hansenii chromosome
E of strain CBS767 of Debaryomyces hansenii -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 438
Score = 42.3 bits (95), Expect = 0.019
Identities = 21/50 (42%), Positives = 35/50 (70%), Gaps = 2/50 (4%)
Query: 26 SNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEK 75
SN+++ K +++++ S+ VV TGAGIS +AGIPDFR +G++ + K
Sbjct: 12 SNEQI--KLSEVSKIIFKSRKAVVLTGAGISCNAGIPDFRSSDGLYNMVK 59
>UniRef50_A4RMS1 Cluster: Putative uncharacterized protein; n=2;
Sordariomycetes|Rep: Putative uncharacterized protein -
Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 666
Score = 42.3 bits (95), Expect = 0.019
Identities = 18/35 (51%), Positives = 26/35 (74%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 71
L ++++ K IV+ GAGIS SAGIPDFR +G++
Sbjct: 132 LTKVLRKKKRIVIIAGAGISVSAGIPDFRSQSGLF 166
>UniRef50_Q5KPC9 Cluster: Hst3 protein, putative; n=2;
Filobasidiella neoformans|Rep: Hst3 protein, putative -
Cryptococcus neoformans (Filobasidiella neoformans)
Length = 389
Score = 41.9 bits (94), Expect = 0.026
Identities = 19/36 (52%), Positives = 26/36 (72%)
Query: 41 VKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKE 76
V ++ IV +GAGIS S+GIPDFR G+++L KE
Sbjct: 32 VAKARRIVTVSGAGISCSSGIPDFRSEGGLYSLVKE 67
>UniRef50_Q4PG00 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 596
Score = 41.9 bits (94), Expect = 0.026
Identities = 19/40 (47%), Positives = 28/40 (70%), Gaps = 1/40 (2%)
Query: 40 LVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT-LEKEGK 78
L+ K I++ +GAGIS S GIPDFR +G++ L+ EG+
Sbjct: 186 LLSTRKRIMILSGAGISVSCGIPDFRSKDGIYAILQSEGQ 225
>UniRef50_A6SP88 Cluster: Putative uncharacterized protein; n=2;
Sclerotiniaceae|Rep: Putative uncharacterized protein -
Botryotinia fuckeliana B05.10
Length = 332
Score = 41.9 bits (94), Expect = 0.026
Identities = 41/144 (28%), Positives = 64/144 (44%), Gaps = 29/144 (20%)
Query: 21 PEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW--------- 71
PE SND + K VL + S ++ GAG+ S+G+ FRGP G+W
Sbjct: 17 PEHRPSNDVASFKKVLAS-----STRVLALCGAGLGASSGLDTFRGPGGMWRNYRSQNLA 71
Query: 72 TLEKEGKKPTI---------NVSFADAQPTKTH-----MXXXXXXXXXXXXXXVSQNIDG 117
TL+ + P + + +FA A+P K H + ++QN+DG
Sbjct: 72 TLDAFTRDPGLVWLFYSYRRHKAFA-AEPNKGHFALGELAKRMKKDGEEGFMCLTQNVDG 130
Query: 118 LHLKSGVPRKFLAELHGNMFIDEC 141
L ++G P L LHG++ +C
Sbjct: 131 LAQRAGHPEGSLKLLHGSLCDIKC 154
>UniRef50_Q9NXA8 Cluster: NAD-dependent deacetylase sirtuin-5;
n=28; Coelomata|Rep: NAD-dependent deacetylase
sirtuin-5 - Homo sapiens (Human)
Length = 310
Score = 41.9 bits (94), Expect = 0.026
Identities = 15/28 (53%), Positives = 21/28 (75%)
Query: 44 SKHIVVHTGAGISTSAGIPDFRGPNGVW 71
+KHIV+ +GAG+S +G+P FRG G W
Sbjct: 50 AKHIVIISGAGVSAESGVPTFRGAGGYW 77
Score = 35.9 bits (79), Expect = 1.7
Identities = 16/34 (47%), Positives = 22/34 (64%), Gaps = 2/34 (5%)
Query: 111 VSQNIDGLHLKSGVPRKFLAELHGNMFIDECNIC 144
++QNID LH K+G K L E+HG++F C C
Sbjct: 138 ITQNIDELHRKAGT--KNLLEIHGSLFKTRCTSC 169
>UniRef50_Q9CBW6 Cluster: NAD-dependent deacetylase; n=14;
Mycobacterium|Rep: NAD-dependent deacetylase -
Mycobacterium leprae
Length = 237
Score = 41.9 bits (94), Expect = 0.026
Identities = 51/240 (21%), Positives = 92/240 (38%), Gaps = 28/240 (11%)
Query: 47 IVVHTGAGISTSAGIPDFRGP-NGVWTL-------EKEG--KKPTI--------NVSFAD 88
+VV +GAGIS + +P FR NG+W +G + P + A+
Sbjct: 3 VVVLSGAGISAESDVPTFRDDKNGLWARFDPYQLSSTQGWQRNPERVWGWYLWRHYLVAN 62
Query: 89 AQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNICKRQF 148
+P H ++QN+D LH ++G + LHG++F C C +
Sbjct: 63 VKPNDGHRAIAAWQEQIEVSV-ITQNVDDLHERAGSTP--VHHLHGSLFKFHCARCNVAY 119
Query: 149 VRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAEWHSSIADL 208
+ P + P + C G + ++ + LP+ A + D+
Sbjct: 120 TGALP-DMPEPVLEVDPPVCY------CGGLIRPAIVWFGEPLPDEPWRRAVEATETTDV 172
Query: 209 SICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYYVDDVLEKVMDIL 268
+ +GT+ + P+ LP + G ++ N +PT A + I L ++ L
Sbjct: 173 MVVVGTSAIVYPAAGLPELALSRGAVVIEVNPEPTPLTKNATISIRETASQALPGLLQRL 232
>UniRef50_Q5P3W1 Cluster: NAD-dependent deacetylase 2; n=4;
Proteobacteria|Rep: NAD-dependent deacetylase 2 -
Azoarcus sp. (strain EbN1) (Aromatoleum aromaticum
(strain EbN1))
Length = 260
Score = 41.5 bits (93), Expect = 0.034
Identities = 53/203 (26%), Positives = 82/203 (40%), Gaps = 37/203 (18%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW---------TLEK--EGKK------ 79
+A+L+ + I+ TGAGIS +G+P +RG G++ T+E+ G+
Sbjct: 10 VARLIAGAPRILFITGAGISADSGLPTYRGIGGLYHERLTDDGLTIEEALSGEMMEAHPE 69
Query: 80 ------PTINVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELH 133
I + A P H ++QN+DGLH +G + L E+H
Sbjct: 70 VAWKYIAEIEANCRGAAPNIAHRIIAALEHERPGVWVLTQNVDGLHRAAG--SRNLIEIH 127
Query: 134 GNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPE 193
G++ C CK RS P + + G P C G L ++ + LPE
Sbjct: 128 GSVHRLRCTECKH--ARSVPDYSGLRIPPGCPV---------CGGVLRPDIVLFGEMLPE 176
Query: 194 NDLLMAE-WHSSIADLSICLGTT 215
L E DL + +GTT
Sbjct: 177 TGLRRLEALLDDGVDLVVSIGTT 199
>UniRef50_A6Q2C0 Cluster: Transcriptional regulator, Sir2 family;
n=2; Bacteria|Rep: Transcriptional regulator, Sir2
family - Nitratiruptor sp. (strain SB155-2)
Length = 268
Score = 41.5 bits (93), Expect = 0.034
Identities = 15/40 (37%), Positives = 25/40 (62%)
Query: 40 LVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKK 79
L+K + ++++ GAG+ +G+PDFRG +G W KK
Sbjct: 8 LIKQADYLLITAGAGMGVDSGLPDFRGVHGFWRAYPAAKK 47
>UniRef50_A4JJP4 Cluster: Silent information regulator protein
Sir2; n=1; Burkholderia vietnamiensis G4|Rep: Silent
information regulator protein Sir2 - Burkholderia
vietnamiensis (strain G4 / LMG 22486)
(Burkholderiacepacia (strain R1808))
Length = 273
Score = 41.5 bits (93), Expect = 0.034
Identities = 14/35 (40%), Positives = 24/35 (68%)
Query: 38 AQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT 72
A + ++ +++ GAG+S +G+PDFRG G+WT
Sbjct: 12 ASWIANADALIIAAGAGMSVDSGLPDFRGSQGIWT 46
>UniRef50_Q7JMD3 Cluster: Putative uncharacterized protein sir-2.2;
n=4; Caenorhabditis|Rep: Putative uncharacterized
protein sir-2.2 - Caenorhabditis elegans
Length = 289
Score = 41.5 bits (93), Expect = 0.034
Identities = 20/59 (33%), Positives = 27/59 (45%), Gaps = 2/59 (3%)
Query: 86 FADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNIC 144
F A P H ++QN+DGLHLK+G K + ELHG+ +C C
Sbjct: 91 FGQAAPNINHYALSKWEASDRFQWLITQNVDGLHLKAG--SKMVTELHGSALQVKCTTC 147
>UniRef50_Q4QB33 Cluster: Sir2-family protein-like protein; n=4;
Trypanosomatidae|Rep: Sir2-family protein-like protein
- Leishmania major
Length = 320
Score = 41.5 bits (93), Expect = 0.034
Identities = 18/28 (64%), Positives = 21/28 (75%)
Query: 42 KDSKHIVVHTGAGISTSAGIPDFRGPNG 69
K + VV TGAG ST +GIPD+RGPNG
Sbjct: 18 KRGRGCVVLTGAGCSTESGIPDYRGPNG 45
>UniRef50_Q7S223 Cluster: Putative uncharacterized protein
NCU05973.1; n=1; Neurospora crassa|Rep: Putative
uncharacterized protein NCU05973.1 - Neurospora crassa
Length = 334
Score = 41.5 bits (93), Expect = 0.034
Identities = 37/164 (22%), Positives = 64/164 (39%), Gaps = 18/164 (10%)
Query: 29 KLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW---------TLEKEGKK 79
++N +L K + + + GAG+S ++G+P FRG G+W T E
Sbjct: 4 RINNLAAFHQKLAKADRILAI-CGAGLSAASGLPTFRGVGGLWRNYEATDLATPEAFASD 62
Query: 80 PTINVSF--------ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAE 131
P + F A P H ++QN+D L ++G ++ L
Sbjct: 63 PGLVWLFYAYRRHMALQALPNAGHHALAALAKKNPNFLCLTQNVDNLSSRAGHQQQQLHT 122
Query: 132 LHGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRP 175
LHG++F +C+ Q T+ C + A+ + P
Sbjct: 123 LHGSLFTLQCSSYPSQCTYIDKNNTLDPLCPALAPASASASINP 166
>UniRef50_Q55DB0 Cluster: NAD(+)-dependent deacetylase, silent
information regulator protein (Sir2) family protein;
n=1; Dictyostelium discoideum AX4|Rep: NAD(+)-dependent
deacetylase, silent information regulator protein (Sir2)
family protein - Dictyostelium discoideum AX4
Length = 346
Score = 41.1 bits (92), Expect = 0.045
Identities = 35/125 (28%), Positives = 55/125 (44%), Gaps = 21/125 (16%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPN-GVW--------TLEKEGKKPTI----- 82
LA+ + K I+ TGAG+S ++GI +R VW T +K + P
Sbjct: 37 LAKEMLSGKKILFITGAGLSINSGISAYRNTKTSVWSNFITEWGTRKKFEQDPAQFWNHF 96
Query: 83 ------NVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNM 136
+ DA P H+ ++QN+D LHLK+ VP + L E+HG +
Sbjct: 97 WLRTHEKQEYLDALPNSGHLAISNFVEYLGSNV-ITQNVDALHLKAKVPIEKLVEVHGRI 155
Query: 137 FIDEC 141
+ +C
Sbjct: 156 SLYKC 160
>UniRef50_Q875P9 Cluster: HST1; n=1; Lachancea kluyveri|Rep: HST1 -
Saccharomyces kluyveri (Yeast) (Saccharomyces
silvestris)
Length = 414
Score = 41.1 bits (92), Expect = 0.045
Identities = 18/35 (51%), Positives = 25/35 (71%)
Query: 38 AQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT 72
A +K ++ ++V TGAGISTS GIPDFR G ++
Sbjct: 77 AAKLKTARRVLVLTGAGISTSLGIPDFRSSEGFYS 111
Score = 37.9 bits (84), Expect = 0.42
Identities = 23/67 (34%), Positives = 34/67 (50%), Gaps = 2/67 (2%)
Query: 207 DLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYYVDDVLEKVMD 266
DL IC+GT+L++ P + + + V+ N P KH + DL + + DDV V
Sbjct: 322 DLLICIGTSLKVAPVSEI-VNMVPANVPQVLINKDPVKH-AEFDLSLLGFCDDVAALVAQ 379
Query: 267 ILGIEIP 273
G EIP
Sbjct: 380 KCGWEIP 386
>UniRef50_Q4P1X1 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 434
Score = 41.1 bits (92), Expect = 0.045
Identities = 50/211 (23%), Positives = 77/211 (36%), Gaps = 31/211 (14%)
Query: 44 SKHIVVHTGAGISTSAG--IPDFRGPN-GVWTLEKEGKKPTINVSF-------------- 86
+++++V GAGISTSA IPDFR P G++ P F
Sbjct: 48 TRNVIVLAGAGISTSASPPIPDFRSPGTGLYANLAAYNLPYAEAIFDIGYFQRHPQPFFT 107
Query: 87 -------ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFID 139
+ +P H +QN+D L +GV + E HG+
Sbjct: 108 LAKHLYPGNFKPALAHYFLTLLQRKQKLKRVFTQNVDTLERIAGVEADKVVEAHGSFATS 167
Query: 140 ECNICKR----QFVRSSPVETVGKKCSGVPCAAHHV--TGRPCRGRLYDGVLDWEHSLPE 193
C +CK ++R+ +C C G G + ++ + SLP
Sbjct: 168 TCIVCKHSVDDDWIRNKVESGQVARCPRPKCPGRKTGSKGEQRGGLVKPDIVFFGESLPP 227
Query: 194 NDLLMAEWHSSIADLSICLGTTLQIVPSGNL 224
ADL I +GT+LQ+ P +L
Sbjct: 228 R-FFRCIPDLKTADLLIVMGTSLQVQPFASL 257
>UniRef50_A1ZHW6 Cluster: NAD-dependent deacetylase; n=2;
Microscilla marina ATCC 23134|Rep: NAD-dependent
deacetylase - Microscilla marina ATCC 23134
Length = 279
Score = 40.7 bits (91), Expect = 0.059
Identities = 18/38 (47%), Positives = 22/38 (57%)
Query: 43 DSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKP 80
D +VV TGAGIS +GIP FRG G W + +P
Sbjct: 17 DQAKMVVLTGAGISAESGIPTFRGKEGYWKIGSVNYQP 54
>UniRef50_Q2U9Y7 Cluster: Sirtuin 4 and related class II sirtuins;
n=10; Pezizomycotina|Rep: Sirtuin 4 and related class II
sirtuins - Aspergillus oryzae
Length = 407
Score = 40.7 bits (91), Expect = 0.059
Identities = 36/123 (29%), Positives = 49/123 (39%), Gaps = 21/123 (17%)
Query: 48 VVHTGAGISTSAGIPDFRGPNGVWTLEK--------------EGKKPTINVSF------A 87
V+ TGAGIS ++G+ D+RG NG + K E +K SF
Sbjct: 85 VLLTGAGISVASGLSDYRGENGTYVTNKTYRPIYFHEFLKRHEFRKRYWARSFVGWPGLV 144
Query: 88 DAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNICKRQ 147
A+P TH V+QN+D H + ELHG + C C+ Q
Sbjct: 145 KAKPNSTHWAIRDLGAKGYLSSVVTQNVDSFH-PIAHSKLSTIELHGYLRSVVCISCQNQ 203
Query: 148 FVR 150
F R
Sbjct: 204 FPR 206
>UniRef50_A2QWZ2 Cluster: Function: human SIRT5 belongs to the
Sir2-like proteins precursor; n=1; Aspergillus
niger|Rep: Function: human SIRT5 belongs to the
Sir2-like proteins precursor - Aspergillus niger
Length = 258
Score = 40.7 bits (91), Expect = 0.059
Identities = 52/221 (23%), Positives = 87/221 (39%), Gaps = 37/221 (16%)
Query: 41 VKDSKHIVVHTGAGISTSAGIPDFRGPNGVW---------TLEKEGKKPTINVSF----- 86
+K + ++ GAGIS S+G+P FRG G+W T E P + F
Sbjct: 18 LKGCRRVIALLGAGISASSGLPTFRGAGGLWRSYDATDLATPEAFDANPDLVWQFYSYRR 77
Query: 87 ---ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNI 143
AQP + H +SQN+D R + L N DE ++
Sbjct: 78 HMALKAQPNRAHYALAELARKNKDFITLSQNVDD-RTGEEASRSIASALGNNE--DEADV 134
Query: 144 CKRQFVRSS-PVETVGKKCSGVPCAAHHVTGRPCR-GRLYDGVLDWEHSLPENDL-LMAE 200
+ S+ P E + C C+ G L GV+ + SLP + + + E
Sbjct: 135 SDERVPLSAVPYEEL-PHCP------------ECKDGLLRPGVVWFGESLPSHTIDYVDE 181
Query: 201 W-HSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNL 240
W + DL + +GT+ ++ P+ + G ++ + N+
Sbjct: 182 WLNKGKVDLILVVGTSSRVYPAAGYVDKARSKGARVAVVNM 222
>UniRef50_Q1EP52 Cluster: Transcriptional regulator Sir2 family
protein; n=1; Musa balbisiana|Rep: Transcriptional
regulator Sir2 family protein - Musa balbisiana (Banana)
Length = 217
Score = 40.3 bits (90), Expect = 0.079
Identities = 18/30 (60%), Positives = 23/30 (76%)
Query: 36 LLAQLVKDSKHIVVHTGAGISTSAGIPDFR 65
LL Q + S+ +VV TGAGIST +GIPD+R
Sbjct: 175 LLYQFIDTSRKLVVLTGAGISTESGIPDYR 204
>UniRef50_Q5KG84 Cluster: Hst4 protein, putative; n=2;
Filobasidiella neoformans|Rep: Hst4 protein, putative -
Cryptococcus neoformans (Filobasidiella neoformans)
Length = 478
Score = 40.3 bits (90), Expect = 0.079
Identities = 23/53 (43%), Positives = 36/53 (67%), Gaps = 4/53 (7%)
Query: 25 DSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEG 77
D D L Q ++A+L + +K IVV +GAG+ST A IPDFR +G+++ + +G
Sbjct: 28 DVEDTLRQ---VVARL-RMAKRIVVVSGAGVSTGAAIPDFRSASGLFSGKTKG 76
>UniRef50_Q2HG51 Cluster: Putative uncharacterized protein; n=2;
Pezizomycotina|Rep: Putative uncharacterized protein -
Chaetomium globosum (Soil fungus)
Length = 594
Score = 40.3 bits (90), Expect = 0.079
Identities = 24/54 (44%), Positives = 29/54 (53%), Gaps = 1/54 (1%)
Query: 41 VKDSKHIVVHTGAGISTSAGIPDFRGPNGVW-TLEKEGKKPTINVSFADAQPTK 93
++ K IVV GAGIS SAGIPDFR G++ TL + K DA K
Sbjct: 46 LRKKKKIVVIAGAGISVSAGIPDFRSSTGLFATLRGQHKLKASGKHLFDASVYK 99
>UniRef50_Q7WLE5 Cluster: NAD-dependent deacetylase; n=47;
Bacteria|Rep: NAD-dependent deacetylase - Bordetella
bronchiseptica (Alcaligenes bronchisepticus)
Length = 274
Score = 40.3 bits (90), Expect = 0.079
Identities = 35/118 (29%), Positives = 49/118 (41%), Gaps = 19/118 (16%)
Query: 44 SKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKE-------GKKPTIN----------VSF 86
S+ + V TGAG ST++GIPD+R G W + G +P F
Sbjct: 18 SERLFVLTGAGCSTASGIPDYRDGQGQWKRKPPIDFQAFMGGQPARARYWARSMVGWRHF 77
Query: 87 ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNIC 144
A+P H V+QN+D LH +G R+ L +LHG + C C
Sbjct: 78 GQARPNAAHHALARLAQRGQVDLLVTQNVDRLHQAAG-GREVL-DLHGRLDEVRCMQC 133
>UniRef50_A7H7B6 Cluster: Silent information regulator protein Sir2;
n=2; Anaeromyxobacter|Rep: Silent information regulator
protein Sir2 - Anaeromyxobacter sp. Fw109-5
Length = 270
Score = 39.9 bits (89), Expect = 0.10
Identities = 36/128 (28%), Positives = 49/128 (38%), Gaps = 24/128 (18%)
Query: 36 LLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKP---TINVSFA----- 87
LL + + +V TGAG+S +GIP FRG G W + P + FA
Sbjct: 8 LLDDVRRAQGRVVALTGAGVSAESGIPTFRGREGFWVVGSRNYMPQEMATHEMFARAPEE 67
Query: 88 -------------DAQPTKTHMX-XXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELH 133
DA+P H V+QNIDGLH ++G R +H
Sbjct: 68 VWRWYLHRFGVCRDARPNAGHAALVALERALGERFTLVTQNIDGLHRRAGSERVLC--IH 125
Query: 134 GNMFIDEC 141
G+ C
Sbjct: 126 GDAAYVRC 133
>UniRef50_A3WK56 Cluster: SIR2-like regulatory protein,
NAD-dependent protein deacetylase; n=1; Idiomarina
baltica OS145|Rep: SIR2-like regulatory protein,
NAD-dependent protein deacetylase - Idiomarina baltica
OS145
Length = 279
Score = 39.9 bits (89), Expect = 0.10
Identities = 31/127 (24%), Positives = 51/127 (40%), Gaps = 19/127 (14%)
Query: 35 VLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT----------LEKEGKKPTI-- 82
V A+L++ + + +GAG+ST +GIP +R G W + + +
Sbjct: 9 VKAAELLRGNTPFTLLSGAGLSTDSGIPAYRNAQGQWVHSPPMQHHDFMNNDAARKRYWA 68
Query: 83 -----NVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMF 137
++ AQP + H ++QN+DGLH K+G + LHG
Sbjct: 69 RSLGGWLNLYHAQPNRAHQVIAQFQQHGFIDTVITQNVDGLHQKAG--SSTVINLHGYAN 126
Query: 138 IDECNIC 144
C C
Sbjct: 127 DIVCMTC 133
>UniRef50_A0DQW0 Cluster: Chromosome undetermined scaffold_6, whole
genome shotgun sequence; n=3; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_6,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 367
Score = 39.9 bits (89), Expect = 0.10
Identities = 17/52 (32%), Positives = 31/52 (59%)
Query: 25 DSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKE 76
+ N K Q+ + +K++++ GAG+S ++G+P FRG +G WT K+
Sbjct: 101 EQNPKTAQEVTVEQAQKLITKNVLILCGAGLSHASGVPTFRGKDGYWTKGKD 152
>UniRef50_Q4P3S4 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 400
Score = 39.9 bits (89), Expect = 0.10
Identities = 24/62 (38%), Positives = 35/62 (56%), Gaps = 3/62 (4%)
Query: 36 LLAQLVKDSK-HIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSFADAQPTKT 94
L+A+ V +K ++ TGAGIS +GI +RG NG +T+ K +P F DA K
Sbjct: 27 LVAEFVSAAKGKALIMTGAGISVDSGIAPYRGENGHYTIHKH-YRPIFYHEFVDAS-DKG 84
Query: 95 HM 96
H+
Sbjct: 85 HL 86
>UniRef50_P53687 Cluster: NAD-dependent histone deacetylase HST3;
n=6; Saccharomycetales|Rep: NAD-dependent histone
deacetylase HST3 - Saccharomyces cerevisiae (Baker's
yeast)
Length = 447
Score = 39.9 bits (89), Expect = 0.10
Identities = 18/33 (54%), Positives = 24/33 (72%)
Query: 44 SKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKE 76
S+ I TGAGIS +AGIPDFR +G++ L K+
Sbjct: 52 SRRIACLTGAGISCNAGIPDFRSSDGLYDLVKK 84
>UniRef50_UPI00015B48CB Cluster: PREDICTED: similar to 85 kda
calcium-independent phospholipase A2 (ipla2); n=1;
Nasonia vitripennis|Rep: PREDICTED: similar to 85 kda
calcium-independent phospholipase A2 (ipla2) - Nasonia
vitripennis
Length = 811
Score = 39.5 bits (88), Expect = 0.14
Identities = 20/54 (37%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 25 DSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGK 78
D + L +KC+ LA + +V + A IS + IPD+RG NG+W + GK
Sbjct: 65 DIPEILEEKCIRLAAAISRETSLV-YIVADISIAVSIPDYRGINGMWARMQLGK 117
>UniRef50_UPI000023E2DA Cluster: hypothetical protein FG00460.1;
n=1; Gibberella zeae PH-1|Rep: hypothetical protein
FG00460.1 - Gibberella zeae PH-1
Length = 607
Score = 39.5 bits (88), Expect = 0.14
Identities = 19/39 (48%), Positives = 24/39 (61%)
Query: 37 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEK 75
L ++ K IVV GAGIS +AGIPDFR G++ K
Sbjct: 123 LRDTLRKKKKIVVIAGAGISVAAGIPDFRSSTGLFASVK 161
>UniRef50_Q4HK96 Cluster: Putative uncharacterized protein; n=1;
Campylobacter lari RM2100|Rep: Putative uncharacterized
protein - Campylobacter lari RM2100
Length = 585
Score = 39.5 bits (88), Expect = 0.14
Identities = 30/109 (27%), Positives = 53/109 (48%), Gaps = 4/109 (3%)
Query: 245 HDNKADLLINYYVDDVLEKVMDILGIEIPSYNESENPMKFAETAIID--WSIDRKDVLAL 302
HDN +L N+Y ++L+ ++D I ++ E+ N M + + ++ID+ D+ +
Sbjct: 274 HDNFIHILKNHYYSNILQAILDYY-IPTKNFLENTNNMYIITSNYMKNFFTIDKADIEKI 332
Query: 303 EKTFKSKCKGVKKKRI-LIKTKRFTSNANDIEKSKMIKLEVKEENETKD 350
F S+ + + I + N+NDIE SK I+ VK KD
Sbjct: 333 NYDFTSRLQNLIDMHFHTIYNMFYVYNSNDIECSKAIEDLVKMFLPIKD 381
>UniRef50_A1ZZG3 Cluster: NAD-dependent deacetylase; n=35;
Bacteria|Rep: NAD-dependent deacetylase - Microscilla
marina ATCC 23134
Length = 245
Score = 39.5 bits (88), Expect = 0.14
Identities = 36/124 (29%), Positives = 55/124 (44%), Gaps = 20/124 (16%)
Query: 30 LNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW-------TLEKEG--KKP 80
L+ K +++ + + IVV TGAGIS +GI FR +G+W EG K
Sbjct: 2 LSFKSQQVSKSIMSKQKIVVLTGAGISAESGISTFRDSDGLWENHDVMEVASPEGWQKDR 61
Query: 81 TINVSFAD--------AQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAEL 132
+ + F + AQP + H+ ++QNID LH K+G + L
Sbjct: 62 ALVLEFYNQRRTHALAAQPNEGHL-ALARLEAKYEVVIITQNIDDLHEKAGSSN--VLHL 118
Query: 133 HGNM 136
HG +
Sbjct: 119 HGEL 122
>UniRef50_A0JXS0 Cluster: Silent information regulator protein Sir2
precursor; n=11; Actinomycetales|Rep: Silent information
regulator protein Sir2 precursor - Arthrobacter sp.
(strain FB24)
Length = 306
Score = 39.5 bits (88), Expect = 0.14
Identities = 31/116 (26%), Positives = 51/116 (43%), Gaps = 17/116 (14%)
Query: 51 TGAGISTSAGIPDFRGPNGV----WTLEK----EGKKPTI----NVSFAD---AQPTKTH 95
TGAG+ST +GIPD+RGP+ T ++ G + ++ ++ A P H
Sbjct: 48 TGAGLSTDSGIPDYRGPDAAPRAPMTYQEFIGHAGNRQRYWARNHIGWSHLRRADPNDGH 107
Query: 96 MXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNICKRQFVRS 151
++QN+D LH +G + +LHG C C R++ R+
Sbjct: 108 AAAARLEQRGLLTGLITQNVDRLHEDAGSVN--VVDLHGRFDRVACLSCARRYSRT 161
>UniRef50_Q23YS7 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Tetrahymena thermophila SB210|Rep:
Transcriptional regulator, Sir2 family protein -
Tetrahymena thermophila SB210
Length = 304
Score = 39.5 bits (88), Expect = 0.14
Identities = 13/36 (36%), Positives = 24/36 (66%)
Query: 36 LLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 71
L+A+ ++ + +++ GAG+ +G+PDFRG G W
Sbjct: 8 LIAKRIQSASCLIITAGAGMGVDSGLPDFRGKEGFW 43
>UniRef50_UPI0000DB7785 Cluster: PREDICTED: similar to CG6216-PA,
isoform A; n=1; Apis mellifera|Rep: PREDICTED: similar
to CG6216-PA, isoform A - Apis mellifera
Length = 278
Score = 39.1 bits (87), Expect = 0.18
Identities = 29/72 (40%), Positives = 38/72 (52%), Gaps = 5/72 (6%)
Query: 285 AETAIIDWSIDRKDVLALEKTFKSKCKGVKKKRILIKTKRFTSNANDI-EKSKMIKLEVK 343
A+T I ++DRK +K K K K R+LI++KR S AND+ KS KL
Sbjct: 199 ADTEAIIANMDRKKKRKRKKRIKIK-NTRKNSRLLIRSKRMKSMANDLGRKSNKDKL--- 254
Query: 344 EENETKDWPLKP 355
E NE P+KP
Sbjct: 255 ENNENNSKPVKP 266
>UniRef50_A4A980 Cluster: NAD-dependent deacetylase; n=5;
Gammaproteobacteria|Rep: NAD-dependent deacetylase -
Congregibacter litoralis KT71
Length = 241
Score = 39.1 bits (87), Expect = 0.18
Identities = 15/30 (50%), Positives = 19/30 (63%)
Query: 51 TGAGISTSAGIPDFRGPNGVWTLEKEGKKP 80
TGAG+S +GIP FRG +G WT+ P
Sbjct: 7 TGAGVSAESGIPTFRGEDGFWTIGSRNYTP 36
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.316 0.135 0.404
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 420,893,956
Number of Sequences: 1657284
Number of extensions: 17855703
Number of successful extensions: 44569
Number of sequences better than 10.0: 295
Number of HSP's better than 10.0 without gapping: 256
Number of HSP's successfully gapped in prelim test: 39
Number of HSP's that attempted gapping in prelim test: 43900
Number of HSP's gapped (non-prelim): 582
length of query: 370
length of database: 575,637,011
effective HSP length: 102
effective length of query: 268
effective length of database: 406,594,043
effective search space: 108967203524
effective search space used: 108967203524
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.6 bits)
S2: 73 (33.5 bits)
- SilkBase 1999-2023 -