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Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= BGIBMGA001401-TA|BGIBMGA001401-PA|IPR003000|Silent information
regulator protein Sir2
         (370 letters)

Database: nematostella 
           59,808 sequences; 16,821,457 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

SB_11507| Best HMM Match : SIR2 (HMM E-Value=3.4e-11)                 206   2e-53
SB_42699| Best HMM Match : SIR2 (HMM E-Value=1.6e-12)                  96   5e-20
SB_39846| Best HMM Match : SIR2 (HMM E-Value=1.4013e-45)               53   4e-07
SB_13626| Best HMM Match : No HMM Matches (HMM E-Value=.)              47   3e-05
SB_52117| Best HMM Match : No HMM Matches (HMM E-Value=.)              46   7e-05
SB_17507| Best HMM Match : SIR2 (HMM E-Value=0.00019)                  45   9e-05
SB_43176| Best HMM Match : No HMM Matches (HMM E-Value=.)              45   9e-05
SB_8770| Best HMM Match : No HMM Matches (HMM E-Value=.)               31   1.5  
SB_42837| Best HMM Match : No HMM Matches (HMM E-Value=.)              31   1.5  
SB_52909| Best HMM Match : No HMM Matches (HMM E-Value=.)              31   2.0  
SB_41513| Best HMM Match : RVT_1 (HMM E-Value=8.9e-21)                 31   2.0  
SB_55351| Best HMM Match : No HMM Matches (HMM E-Value=.)              31   2.0  
SB_907| Best HMM Match : RVT_1 (HMM E-Value=1.3e-27)                   30   3.5  
SB_23337| Best HMM Match : Ank (HMM E-Value=5.1e-07)                   29   4.6  
SB_3382| Best HMM Match : WD40 (HMM E-Value=2.8e-05)                   29   6.1  
SB_52409| Best HMM Match : No HMM Matches (HMM E-Value=.)              29   6.1  
SB_47950| Best HMM Match : No HMM Matches (HMM E-Value=.)              29   6.1  
SB_57640| Best HMM Match : DUF632 (HMM E-Value=2.8)                    29   8.0  
SB_45941| Best HMM Match : DUF632 (HMM E-Value=2.8)                    29   8.0  
SB_13176| Best HMM Match : No HMM Matches (HMM E-Value=.)              29   8.0  

>SB_11507| Best HMM Match : SIR2 (HMM E-Value=3.4e-11)
          Length = 813

 Score =  206 bits (504), Expect = 2e-53
 Identities = 96/181 (53%), Positives = 127/181 (70%), Gaps = 1/181 (0%)

Query: 24  FDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTIN 83
           FDS  +L  K   LA++++ +K +VVHTGAG+ST+AGIPDFRGP GVWTLE++G  P I+
Sbjct: 164 FDSESELASKVSHLAEMIRAAKRVVVHTGAGVSTAAGIPDFRGPKGVWTLEEKGITPKID 223

Query: 84  VSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNI 143
           VSF  A PT THM              +SQN+DGLHLKSG PR  L+ELHGNMF+++C+ 
Sbjct: 224 VSFDSAAPTLTHMAIVKLQEEGLVHYVISQNVDGLHLKSGYPRSKLSELHGNMFVEKCDK 283

Query: 144 CKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAEWHS 203
           C +++VR++ V +VG+K SG  C      G  CRG+L D +LDWEH+LP NDL+ AE +S
Sbjct: 284 CNKEYVRTTAVASVGQKRSGRACTQTRQRG-SCRGKLCDTILDWEHNLPYNDLVNAEKNS 342

Query: 204 S 204
           S
Sbjct: 343 S 343


>SB_42699| Best HMM Match : SIR2 (HMM E-Value=1.6e-12)
          Length = 501

 Score = 95.9 bits (228), Expect = 5e-20
 Identities = 65/208 (31%), Positives = 103/208 (49%), Gaps = 17/208 (8%)

Query: 22  EKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAG-----IPDFRGPNGVWTLEKE 76
           E  D  + L  K   L   ++++K + ++TGAGIST        +  F GPNG+WT   +
Sbjct: 74  EVLDPEEILEDKVCQLVGAIREAKTLAIYTGAGISTVKFRLIYCLRFFSGPNGIWTRLAK 133

Query: 77  GKKPTINVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNM 136
           G++   + +  DA+PT +HM              VSQN DGLH++SG+P + L+E+HGNM
Sbjct: 134 GERLG-SYNLCDAEPTLSHMSITKLYQEGLVRHVVSQNCDGLHIRSGLPSQALSEVHGNM 192

Query: 137 FIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGR---PCRGRLYDGVLDW-EHSLP 192
           F + C  C+   +     +   +          H TGR    C   L D ++ + E    
Sbjct: 193 FTEVCTECEDDRIYYRLFDVTER-----TAVRRHQTGRFCTDCGSPLRDTIVHFGEKGCL 247

Query: 193 ENDL-LMAEWH-SSIADLSICLGTTLQI 218
           E  L   A +  + IAD  +CLG++L++
Sbjct: 248 EQPLNWQAAFDVAKIADCILCLGSSLKV 275


>SB_39846| Best HMM Match : SIR2 (HMM E-Value=1.4013e-45)
          Length = 427

 Score = 52.8 bits (121), Expect = 4e-07
 Identities = 73/290 (25%), Positives = 118/290 (40%), Gaps = 46/290 (15%)

Query: 20  VPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGP-NGVWTLEKEG- 77
           VPE   S  +L+     L + + ++  I V TGAGIST +GI D+R    G++ +  +  
Sbjct: 140 VPEFHTSKQELSYITSRLDEFIAENPKIFVITGAGISTESGIRDYRSEGKGLYAITNDRP 199

Query: 78  -------KKPTIN-----------VSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLH 119
                  K   +              F   QP + H               V+QN+D LH
Sbjct: 200 MEYQVFLKSAVMRQRYWARNYVGWPEFGSRQPNEAHYALAKLETLGSVHSLVTQNVDALH 259

Query: 120 LKSGVPRKFLAELHG---NMFIDECN-ICKRQFVRSSPVE------TVGKKCSGVPCAAH 169
            K+G   K + ELHG    +    CN I  R  ++   +E       VG+     P    
Sbjct: 260 TKAG--SKNVIELHGCSHRVICLGCNQITARTALQKRMIEFNPDWHAVGQ--GQAPDGDT 315

Query: 170 HVTGR--------PCR---GRLYDGVLDWEHSLPENDLLMAEWHSSIADLSICLGTTLQI 218
            +T          PC+   G L   V+ +  S+P+  + +A    + +D    +G+T+++
Sbjct: 316 FLTSEAVKDFKVPPCKACGGILKPEVVFFGDSVPKQIVNIAYDRLAESDALWIIGSTVEV 375

Query: 219 VPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYYVDDVLEKVMDIL 268
             S     E  K G  + I N+  T+ D  A L ++     VL K +D+L
Sbjct: 376 YSSYRFATEASKQGKPIAILNIGKTRADKLASLKVSGVCGTVLPK-LDLL 424


>SB_13626| Best HMM Match : No HMM Matches (HMM E-Value=.)
          Length = 155

 Score = 46.8 bits (106), Expect = 3e-05
 Identities = 20/33 (60%), Positives = 26/33 (78%)

Query: 243 TKHDNKADLLINYYVDDVLEKVMDILGIEIPSY 275
           T  D KADL INYYVDDV++++M+ L +EIP Y
Sbjct: 16  TVEDKKADLKINYYVDDVMKQLMENLELEIPQY 48


>SB_52117| Best HMM Match : No HMM Matches (HMM E-Value=.)
          Length = 545

 Score = 45.6 bits (103), Expect = 7e-05
 Identities = 37/126 (29%), Positives = 49/126 (38%), Gaps = 22/126 (17%)

Query: 45  KHIVVHTGAGISTSAGIPDFRGP-NGVWTLEKEGKKPTINVSF----------------- 86
           K+I+V  GAGIST +GIPDFR P  G++   +E   P     F                 
Sbjct: 111 KNIIVMAGAGISTPSGIPDFRTPGTGLYDNLQEYNIPEPTAIFDIEYFWYDPRPFFCLAK 170

Query: 87  ----ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDECN 142
                + QP   H                +QNIDGL   +G+P + L E HG      C 
Sbjct: 171 TLYPGNYQPNYVHYFVKLLHDKGFLLRMYTQNIDGLERLAGLPAEKLVEAHGTFSTASCI 230

Query: 143 ICKRQF 148
            C   +
Sbjct: 231 SCHHSY 236


>SB_17507| Best HMM Match : SIR2 (HMM E-Value=0.00019)
          Length = 202

 Score = 45.2 bits (102), Expect = 9e-05
 Identities = 19/23 (82%), Positives = 21/23 (91%)

Query: 45  KHIVVHTGAGISTSAGIPDFRGP 67
           KHI+V TGAGIST+AGIPDFR P
Sbjct: 121 KHIIVMTGAGISTAAGIPDFRSP 143


>SB_43176| Best HMM Match : No HMM Matches (HMM E-Value=.)
          Length = 639

 Score = 45.2 bits (102), Expect = 9e-05
 Identities = 18/35 (51%), Positives = 27/35 (77%)

Query: 37  LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 71
           + +L+K  K+I+V TGAG+S S GIPDFR  +G++
Sbjct: 111 VVRLIKKCKNIIVLTGAGVSVSCGIPDFRSRDGIY 145


>SB_8770| Best HMM Match : No HMM Matches (HMM E-Value=.)
          Length = 1303

 Score = 31.1 bits (67), Expect = 1.5
 Identities = 21/83 (25%), Positives = 36/83 (43%), Gaps = 4/83 (4%)

Query: 10  SPYENKGILGVPEKFDSNDKLNQKCVLLAQLVK-DSKHIVVHTGAGISTSAGIPDFRGPN 68
           +P    GI  VP   + + KL +K   +    K + K ++    AG+   +  PDF    
Sbjct: 143 NPDRPAGIPVVPVYDEDDAKLKRKVQRITSPEKWELKQLIA---AGVLDKSDYPDFDEDT 199

Query: 69  GVWTLEKEGKKPTINVSFADAQP 91
           G+   E +G    + +  AD +P
Sbjct: 200 GILPKEDDGSDEDVEIEMADEEP 222


>SB_42837| Best HMM Match : No HMM Matches (HMM E-Value=.)
          Length = 131

 Score = 31.1 bits (67), Expect = 1.5
 Identities = 19/62 (30%), Positives = 33/62 (53%)

Query: 303 EKTFKSKCKGVKKKRILIKTKRFTSNANDIEKSKMIKLEVKEENETKDWPLKPSDQEFII 362
           +K  + K K  KKK+   K K+   N N  +K K +K + +EE E  +  L+  ++E  I
Sbjct: 20  KKKKQKKKKKKKKKKKKKKNKKNKKNKNKNKKKKKMKKKKEEEAEVGEKTLEAENEEEKI 79

Query: 363 DQ 364
           ++
Sbjct: 80  EE 81


>SB_52909| Best HMM Match : No HMM Matches (HMM E-Value=.)
          Length = 55

 Score = 30.7 bits (66), Expect = 2.0
 Identities = 15/45 (33%), Positives = 20/45 (44%)

Query: 140 ECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGV 184
           +C   K + V+   V+  G KC GV C      G  C G   +GV
Sbjct: 7   KCECVKCECVKCEGVKCEGVKCEGVKCEGVKCEGVKCEGVKCEGV 51


>SB_41513| Best HMM Match : RVT_1 (HMM E-Value=8.9e-21)
          Length = 1080

 Score = 30.7 bits (66), Expect = 2.0
 Identities = 15/41 (36%), Positives = 21/41 (51%), Gaps = 2/41 (4%)

Query: 140  ECNICKRQFVRSSP--VETVGKKCSGVPCAAHHVTGRPCRG 178
            EC  C+R+  RSS    + +GKKC+      H    + CRG
Sbjct: 1016 ECYRCRRKAHRSSDKVCKALGKKCNNCGVVRHFAKSKFCRG 1056


>SB_55351| Best HMM Match : No HMM Matches (HMM E-Value=.)
          Length = 337

 Score = 30.7 bits (66), Expect = 2.0
 Identities = 15/41 (36%), Positives = 21/41 (51%), Gaps = 2/41 (4%)

Query: 140 ECNICKRQFVRSSP--VETVGKKCSGVPCAAHHVTGRPCRG 178
           EC  C+R+  RSS    + +GKKC+      H    + CRG
Sbjct: 273 ECYRCRRKAHRSSDKVCKALGKKCNNCGVVRHFAKSKFCRG 313


>SB_907| Best HMM Match : RVT_1 (HMM E-Value=1.3e-27)
          Length = 681

 Score = 29.9 bits (64), Expect = 3.5
 Identities = 18/59 (30%), Positives = 28/59 (47%)

Query: 260 VLEKVMDILGIEIPSYNESENPMKFAETAIIDWSIDRKDVLALEKTFKSKCKGVKKKRI 318
           +L K  D + + IP  + S +        I DWS + +  L L KT++   +G  KK I
Sbjct: 615 LLVKYADDITLSIPQRHNSADLSSVEVQNIKDWSKENRMTLNLSKTWEMVVRGRTKKPI 673


>SB_23337| Best HMM Match : Ank (HMM E-Value=5.1e-07)
          Length = 213

 Score = 29.5 bits (63), Expect = 4.6
 Identities = 17/64 (26%), Positives = 30/64 (46%), Gaps = 2/64 (3%)

Query: 1   MSCNYAEGLSPYENKGILGVPEKFDSNDKL--NQKCVLLAQLVKDSKHIVVHTGAGISTS 58
           MS +  + +  +EN  I  + EK+DS++K+    K  +L + V    H+ V         
Sbjct: 83  MSYDRLDAVDAFENDSISSMDEKYDSDEKVVRGSKPQILNKAVLSGDHVTVTKFLDRKVD 142

Query: 59  AGIP 62
           A +P
Sbjct: 143 ANLP 146


>SB_3382| Best HMM Match : WD40 (HMM E-Value=2.8e-05)
          Length = 375

 Score = 29.1 bits (62), Expect = 6.1
 Identities = 12/25 (48%), Positives = 16/25 (64%)

Query: 340 LEVKEENETKDWPLKPSDQEFIIDQ 364
           L+  EE+E +DW +KPSD   I  Q
Sbjct: 137 LQPDEEDEKQDWEIKPSDNLVITGQ 161


>SB_52409| Best HMM Match : No HMM Matches (HMM E-Value=.)
          Length = 473

 Score = 29.1 bits (62), Expect = 6.1
 Identities = 11/36 (30%), Positives = 18/36 (50%)

Query: 113 QNIDGLHLKSGVPRKFLAELHGNMFIDECNICKRQF 148
           +NID L   +G+    L E HG+     C  C +++
Sbjct: 299 ENIDTLERVAGITGDHLMEAHGSFHTGHCMACNKEY 334


>SB_47950| Best HMM Match : No HMM Matches (HMM E-Value=.)
          Length = 296

 Score = 29.1 bits (62), Expect = 6.1
 Identities = 21/63 (33%), Positives = 35/63 (55%), Gaps = 2/63 (3%)

Query: 299 VLALEKTFKSKCKG--VKKKRILIKTKRFTSNANDIEKSKMIKLEVKEENETKDWPLKPS 356
           V A E+T ++K KG   K+KR     +   + A+D  K+K  K++ K++ E  +  L+ S
Sbjct: 186 VKAKEQTSRTKRKGKKEKRKRKTEVIEISDNEASDTGKAKETKIKKKKDKERVESILEIS 245

Query: 357 DQE 359
           D E
Sbjct: 246 DSE 248


>SB_57640| Best HMM Match : DUF632 (HMM E-Value=2.8)
          Length = 560

 Score = 28.7 bits (61), Expect = 8.0
 Identities = 15/50 (30%), Positives = 29/50 (58%)

Query: 180 LYDGVLDWEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETI 229
           L+D  LD   SL   + ++AEW++++  L+  L  T+  +   +LPL+ +
Sbjct: 282 LWDKCLDVLSSLTHWEEVIAEWNTTLQTLTRVLARTVYNLDLDDLPLDRL 331


>SB_45941| Best HMM Match : DUF632 (HMM E-Value=2.8)
          Length = 688

 Score = 28.7 bits (61), Expect = 8.0
 Identities = 15/50 (30%), Positives = 29/50 (58%)

Query: 180 LYDGVLDWEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETI 229
           L+D  LD   SL   + ++AEW++++  L+  L  T+  +   +LPL+ +
Sbjct: 326 LWDKCLDVLSSLTHWEEVIAEWNTTLQTLTRVLARTVYNLDLDDLPLDRL 375


>SB_13176| Best HMM Match : No HMM Matches (HMM E-Value=.)
          Length = 505

 Score = 28.7 bits (61), Expect = 8.0
 Identities = 15/52 (28%), Positives = 26/52 (50%)

Query: 282 MKFAETAIIDWSIDRKDVLALEKTFKSKCKGVKKKRILIKTKRFTSNANDIE 333
           M+ ++T  +  ++D  ++    +T KSKC    KKRI  K+   T   N  +
Sbjct: 154 MRSSQTRTLSTTLDDNEMTLKSETTKSKCSKECKKRINEKSNGKTVKENQFD 205


  Database: nematostella
    Posted date:  Oct 22, 2007  1:22 PM
  Number of letters in database: 16,821,457
  Number of sequences in database:  59,808
  
Lambda     K      H
   0.316    0.135    0.404 

Gapped
Lambda     K      H
   0.279   0.0580    0.190 


Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 12,911,116
Number of Sequences: 59808
Number of extensions: 554420
Number of successful extensions: 1284
Number of sequences better than 10.0: 20
Number of HSP's better than 10.0 without gapping: 15
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 1248
Number of HSP's gapped (non-prelim): 30
length of query: 370
length of database: 16,821,457
effective HSP length: 83
effective length of query: 287
effective length of database: 11,857,393
effective search space: 3403071791
effective search space used: 3403071791
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.6 bits)
S2: 61 (28.7 bits)

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