Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001401-TA|BGIBMGA001401-PA|IPR003000|Silent information
regulator protein Sir2
(370 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
CR457200-1|CAG33481.1| 355|Homo sapiens SIRT6 protein. 316 1e-85
AF233396-1|AAF43432.1| 355|Homo sapiens sir2-related protein ty... 315 2e-85
AK074810-1|BAC11222.1| 355|Homo sapiens protein ( Homo sapiens ... 314 2e-85
BC005026-1|AAH05026.1| 355|Homo sapiens sirtuin (silent mating ... 314 4e-85
AC006930-1|AAD15478.1| 377|Homo sapiens R33423_1 protein. 298 2e-80
BC028220-1|AAH28220.1| 328|Homo sapiens SIRT6 protein protein. 256 9e-68
BC004218-1|AAH04218.1| 256|Homo sapiens SIRT6 protein protein. 162 2e-39
BC101793-1|AAI01794.1| 400|Homo sapiens sirtuin (silent mating ... 155 2e-37
BC101791-1|AAI01792.1| 400|Homo sapiens sirtuin (silent mating ... 155 2e-37
BC017305-1|AAH17305.1| 400|Homo sapiens sirtuin (silent mating ... 155 2e-37
AF233395-1|AAF43431.1| 400|Homo sapiens sir2-related protein ty... 155 2e-37
AC005620-2|AAC34468.1| 121|Homo sapiens R33590_2, partial CDS p... 98 4e-20
BC000090-1|AAH00090.1| 191|Homo sapiens Unknown (protein for IM... 91 6e-18
AK002027-1|BAA92044.1| 183|Homo sapiens protein ( Homo sapiens ... 79 2e-14
BC001042-1|AAH01042.1| 399|Homo sapiens sirtuin (silent mating ... 61 5e-09
AF083108-1|AAD40851.1| 399|Homo sapiens sirtuin type 3 protein. 61 5e-09
BC012499-1|AAH12499.1| 555|Homo sapiens SIRT1 protein protein. 56 2e-07
DQ278604-1|ABB72675.1| 747|Homo sapiens sirtuin (silent mating ... 56 3e-07
AL133551-8|CAI16036.1| 747|Homo sapiens sirtuin (silent mating ... 56 3e-07
AF235040-1|AAG38486.1| 747|Homo sapiens SIR2alpha protein protein. 56 3e-07
AF083106-1|AAD40849.2| 747|Homo sapiens sirtuin type 1 protein. 56 3e-07
AK131484-1|BAD18629.1| 162|Homo sapiens protein ( Homo sapiens ... 50 1e-05
BC109320-1|AAI09321.1| 314|Homo sapiens sirtuin (silent mating ... 46 2e-04
BC109319-1|AAI09320.1| 314|Homo sapiens sirtuin (silent mating ... 46 2e-04
AF083109-1|AAD40852.1| 314|Homo sapiens sirtuin type 4 protein. 46 2e-04
AJ505014-1|CAD43717.1| 369|Homo sapiens sirtuin type 2 protein. 46 3e-04
AC003982-1|AAB95634.1| 326|Homo sapiens WUGSC:H_166H1.1 protein. 46 3e-04
BC003547-1|AAH03547.1| 352|Homo sapiens sirtuin (silent mating ... 44 7e-04
BC003012-1|AAH03012.1| 352|Homo sapiens sirtuin (silent mating ... 44 7e-04
AY030277-1|AAK51133.1| 352|Homo sapiens SIRT2 protein. 44 7e-04
AF095714-1|AAD45971.1| 352|Homo sapiens silencing information r... 44 7e-04
AF083107-1|AAD40850.2| 389|Homo sapiens sirtuin type 2 protein. 44 7e-04
BC000126-1|AAH00126.1| 310|Homo sapiens sirtuin (silent mating ... 42 0.003
AL441883-2|CAI19838.1| 310|Homo sapiens sirtuin (silent mating ... 42 0.003
AL441883-1|CAI19837.1| 299|Homo sapiens sirtuin (silent mating ... 42 0.003
AK000355-1|BAA91107.1| 299|Homo sapiens protein ( Homo sapiens ... 42 0.003
AF083110-1|AAD40853.1| 310|Homo sapiens sirtuin type 5 protein. 42 0.003
AK131437-1|BAD18583.1| 164|Homo sapiens protein ( Homo sapiens ... 41 0.006
AF131800-1|AAD20046.1| 254|Homo sapiens Similar to rat 5E5 anti... 40 0.014
AF160214-1|AAF67015.1| 373|Homo sapiens silent information regu... 38 0.057
>CR457200-1|CAG33481.1| 355|Homo sapiens SIRT6 protein.
Length = 355
Score = 316 bits (775), Expect = 1e-85
Identities = 153/277 (55%), Positives = 195/277 (70%), Gaps = 1/277 (0%)
Query: 1 MSCNYAEGLSPYENKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAG 60
MS NYA GLSPY +KG G+PE FD ++L +K LA+LV+ S +V HTGAGIST++G
Sbjct: 1 MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVRQSSSVVFHTGAGISTASG 60
Query: 61 IPDFRGPNGVWTLEKEGKKPTINVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHL 120
IPDFRGP+GVWT+E+ G P + +F A+PT+THM VSQN+DGLH+
Sbjct: 61 IPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHV 120
Query: 121 KSGVPRKFLAELHGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTG-RPCRGR 179
+SG PR LAELHGNMF++EC CK Q+VR + V T+G K +G C G R CRG
Sbjct: 121 RSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGE 180
Query: 180 LYDGVLDWEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICN 239
L D +LDWE SLP+ DL +A+ S ADLSI LGT+LQI PSGNLPL T + GG+LVI N
Sbjct: 181 LRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVN 240
Query: 240 LQPTKHDNKADLLINYYVDDVLEKVMDILGIEIPSYN 276
LQPTKHD ADL I+ YVD+V+ ++M LG+EIP+++
Sbjct: 241 LQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWD 277
>AF233396-1|AAF43432.1| 355|Homo sapiens sir2-related protein type
6 protein.
Length = 355
Score = 315 bits (773), Expect = 2e-85
Identities = 153/277 (55%), Positives = 195/277 (70%), Gaps = 1/277 (0%)
Query: 1 MSCNYAEGLSPYENKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAG 60
MS NYA GLSPY +KG G+PE FD ++L +K LA+LV S +V HTGAGIST++G
Sbjct: 1 MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASG 60
Query: 61 IPDFRGPNGVWTLEKEGKKPTINVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHL 120
IPDFRGP+GVWT+E+ G P + +F A+PT+THM VSQN+DGLH+
Sbjct: 61 IPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHV 120
Query: 121 KSGVPRKFLAELHGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTG-RPCRGR 179
+SG PR LAELHGNMF++EC CK Q+VR + V T+G K +G C G R CRG
Sbjct: 121 RSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGE 180
Query: 180 LYDGVLDWEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICN 239
L D +LDWE SLP+ DL +A+ S ADLSI LGT+LQI PSGNLPL T + GG+LVI N
Sbjct: 181 LRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVN 240
Query: 240 LQPTKHDNKADLLINYYVDDVLEKVMDILGIEIPSYN 276
LQPTKHD ADL I+ YVD+V+ ++M+ LG+EIP+++
Sbjct: 241 LQPTKHDRHADLRIHGYVDEVMTRLMEHLGLEIPAWD 277
>AK074810-1|BAC11222.1| 355|Homo sapiens protein ( Homo sapiens
cDNA FLJ90329 fis, clone NT2RP2001948, weakly similar to
HST2 PROTEIN. ).
Length = 355
Score = 314 bits (772), Expect = 2e-85
Identities = 153/277 (55%), Positives = 195/277 (70%), Gaps = 1/277 (0%)
Query: 1 MSCNYAEGLSPYENKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAG 60
MS NYA GLSPY +KG G+PE FD ++L +K LA+LV S ++V HTGAGIST++G
Sbjct: 1 MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSNVVFHTGAGISTASG 60
Query: 61 IPDFRGPNGVWTLEKEGKKPTINVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHL 120
IPDFRGP+GVWT+E+ G P + +F A+PT+THM VSQN+DGLH+
Sbjct: 61 IPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHV 120
Query: 121 KSGVPRKFLAELHGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTG-RPCRGR 179
+SG PR LAELHGNMF++EC CK Q+VR + V T+G K +G C G R CRG
Sbjct: 121 RSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGE 180
Query: 180 LYDGVLDWEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICN 239
L D +LDWE SLP+ DL +A+ S ADLSI LGT+LQI PSGNLPL T + GG+LVI N
Sbjct: 181 LRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVN 240
Query: 240 LQPTKHDNKADLLINYYVDDVLEKVMDILGIEIPSYN 276
LQPTKHD ADL I+ YVD+V+ ++M LG+EIP+++
Sbjct: 241 LQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWD 277
>BC005026-1|AAH05026.1| 355|Homo sapiens sirtuin (silent mating
type information regulation 2 homolog) 6 (S. cerevisiae)
protein.
Length = 355
Score = 314 bits (770), Expect = 4e-85
Identities = 153/277 (55%), Positives = 194/277 (70%), Gaps = 1/277 (0%)
Query: 1 MSCNYAEGLSPYENKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAG 60
MS NYA GLSPY +KG G+PE FD ++L +K LA+LV S +V HTGAGIST++G
Sbjct: 1 MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASG 60
Query: 61 IPDFRGPNGVWTLEKEGKKPTINVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHL 120
IPDFRGP+GVWT+E+ G P + +F A+PT+THM VSQN+DGLH+
Sbjct: 61 IPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHV 120
Query: 121 KSGVPRKFLAELHGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTG-RPCRGR 179
+SG PR LAELHGNMF++EC CK Q+VR + V T+G K +G C G R CRG
Sbjct: 121 RSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGE 180
Query: 180 LYDGVLDWEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICN 239
L D +LDWE SLP+ DL +A+ S ADLSI LGT+LQI PSGNLPL T + GG+LVI N
Sbjct: 181 LRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVN 240
Query: 240 LQPTKHDNKADLLINYYVDDVLEKVMDILGIEIPSYN 276
LQPTKHD ADL I+ YVD+V+ ++M LG+EIP+++
Sbjct: 241 LQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWD 277
>AC006930-1|AAD15478.1| 377|Homo sapiens R33423_1 protein.
Length = 377
Score = 298 bits (731), Expect = 2e-80
Identities = 153/293 (52%), Positives = 194/293 (66%), Gaps = 17/293 (5%)
Query: 1 MSCNYAEGLSPYENKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAG 60
MS NYA GLSPY +KG G+PE FD ++L +K LA+LV S +V HTGAGIST++G
Sbjct: 1 MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASG 60
Query: 61 IPDFRGPNGVWTLEKEGKKPTINVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHL 120
IPDFRGP+GVWT+E+ G P + +F A+PT+THM VSQN+DGLH+
Sbjct: 61 IPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHV 120
Query: 121 KSGVPRKFLAELHGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTG------- 173
+SG PR LAELHGNMF++EC CK Q+VR + V T+G K +G C G
Sbjct: 121 RSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGG 180
Query: 174 --RP--------CRGRLYDGVLDWEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGN 223
P CRG L D +LDWE SLP+ DL +A+ S ADLSI LGT+LQI PSGN
Sbjct: 181 CEAPEDSPQLPHCRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGN 240
Query: 224 LPLETIKYGGKLVICNLQPTKHDNKADLLINYYVDDVLEKVMDILGIEIPSYN 276
LPL T + GG+LVI NLQPTKHD ADL I+ YVD+V+ ++M LG+EIP+++
Sbjct: 241 LPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWD 293
>BC028220-1|AAH28220.1| 328|Homo sapiens SIRT6 protein protein.
Length = 328
Score = 256 bits (627), Expect = 9e-68
Identities = 138/276 (50%), Positives = 177/276 (64%), Gaps = 26/276 (9%)
Query: 1 MSCNYAEGLSPYENKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAG 60
MS NYA GLSPY +KG G+PE FD ++L +K LA+LV S ++V HTGAGIST++G
Sbjct: 1 MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSNVVFHTGAGISTASG 60
Query: 61 IPDFRGPNGVWTLEKEGKKPTINVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHL 120
IPDFRGP+GVWT+E+ G P + +F A+PT+THM VSQN+DGLH+
Sbjct: 61 IPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHV 120
Query: 121 KSGVPRKFLAELHGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRL 180
+SG PR LAELHGNMF++EC CK Q+VR + V T+G K TGR C
Sbjct: 121 RSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKA----------TGRLCTVAK 170
Query: 181 YDGVLDWEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNL 240
G+ + ADLSI LGT+LQI PSGNLPL T + GG+LVI NL
Sbjct: 171 ARGLRACRN----------------ADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNL 214
Query: 241 QPTKHDNKADLLINYYVDDVLEKVMDILGIEIPSYN 276
QPTKHD ADL I+ YVD+V+ ++M LG+EIP+++
Sbjct: 215 QPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWD 250
>BC004218-1|AAH04218.1| 256|Homo sapiens SIRT6 protein protein.
Length = 256
Score = 162 bits (393), Expect = 2e-39
Identities = 93/204 (45%), Positives = 121/204 (59%), Gaps = 26/204 (12%)
Query: 73 LEKEGKKPTINVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAEL 132
+E+ G P + +F A+PT+THM VSQN+DGLH++SG PR LAEL
Sbjct: 1 MEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAEL 60
Query: 133 HGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLP 192
HGNMF++EC CK Q+VR + V T+G K TGR C G+ +
Sbjct: 61 HGNMFVEECAKCKTQYVRDTVVGTMGLKA----------TGRLCTVAKARGLRACRN--- 107
Query: 193 ENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLL 252
ADLSI LGT+LQI PSGNLPL T + GG+LVI NLQPTKHD ADL
Sbjct: 108 -------------ADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRYADLR 154
Query: 253 INYYVDDVLEKVMDILGIEIPSYN 276
I+ YVD+V+ ++M LG+EIP+++
Sbjct: 155 IHGYVDEVMTRLMKHLGLEIPAWD 178
>BC101793-1|AAI01794.1| 400|Homo sapiens sirtuin (silent mating
type information regulation 2 homolog) 7 (S. cerevisiae)
protein.
Length = 400
Score = 155 bits (377), Expect = 2e-37
Identities = 103/272 (37%), Positives = 154/272 (56%), Gaps = 19/272 (6%)
Query: 22 EKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPT 81
E D ++L K LA V+++K++VV+TGAGIST+A IPD+RGPNGVWTL ++G+ +
Sbjct: 77 EVCDDPEELRGKVRELASAVRNAKYLVVYTGAGISTAASIPDYRGPNGVWTLLQKGRSVS 136
Query: 82 INVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDEC 141
++A+PT THM VSQN DGLHL+SG+PR ++ELHGNM+I+ C
Sbjct: 137 A-ADLSEAEPTLTHMSITRLHEQKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVC 195
Query: 142 NIC--KRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCR---GRLYDGVLDW-EHSLPEND 195
C R++VR V V ++ + H TGR C +L D ++ + E
Sbjct: 196 TSCVPNREYVR---VFDVTERTA----LHRHQTGRTCHKCGTQLRDTIVHFGERGTLGQP 248
Query: 196 L--LMAEWHSSIADLSICLGTTLQIV---PSGNLPLETIKYGGKLVICNLQPTKHDNKAD 250
L A +S AD +CLG++L+++ P + KL I NLQ T D+ A
Sbjct: 249 LNWEAATEAASRADTILCLGSSLKVLKKYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAA 308
Query: 251 LLINYYVDDVLEKVMDILGIEIPSYNESENPM 282
L ++ DDV+ +M LG+EIP+Y+ ++P+
Sbjct: 309 LKLHGKCDDVMRLLMAELGLEIPAYSRWQDPI 340
>BC101791-1|AAI01792.1| 400|Homo sapiens sirtuin (silent mating
type information regulation 2 homolog) 7 (S. cerevisiae)
protein.
Length = 400
Score = 155 bits (377), Expect = 2e-37
Identities = 103/272 (37%), Positives = 154/272 (56%), Gaps = 19/272 (6%)
Query: 22 EKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPT 81
E D ++L K LA V+++K++VV+TGAGIST+A IPD+RGPNGVWTL ++G+ +
Sbjct: 77 EVCDDPEELRGKVRELASAVRNAKYLVVYTGAGISTAASIPDYRGPNGVWTLLQKGRSVS 136
Query: 82 INVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDEC 141
++A+PT THM VSQN DGLHL+SG+PR ++ELHGNM+I+ C
Sbjct: 137 A-ADLSEAEPTLTHMSITRLHEQKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVC 195
Query: 142 NIC--KRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCR---GRLYDGVLDW-EHSLPEND 195
C R++VR V V ++ + H TGR C +L D ++ + E
Sbjct: 196 TSCVPNREYVR---VFDVTERTA----LHRHQTGRTCHKCGTQLRDTIVHFGERGTLGQP 248
Query: 196 L--LMAEWHSSIADLSICLGTTLQIV---PSGNLPLETIKYGGKLVICNLQPTKHDNKAD 250
L A +S AD +CLG++L+++ P + KL I NLQ T D+ A
Sbjct: 249 LNWEAATEAASRADTILCLGSSLKVLKKYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAA 308
Query: 251 LLINYYVDDVLEKVMDILGIEIPSYNESENPM 282
L ++ DDV+ +M LG+EIP+Y+ ++P+
Sbjct: 309 LKLHGKCDDVMRLLMAELGLEIPAYSRWQDPI 340
>BC017305-1|AAH17305.1| 400|Homo sapiens sirtuin (silent mating
type information regulation 2 homolog) 7 (S. cerevisiae)
protein.
Length = 400
Score = 155 bits (377), Expect = 2e-37
Identities = 103/272 (37%), Positives = 154/272 (56%), Gaps = 19/272 (6%)
Query: 22 EKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPT 81
E D ++L K LA V+++K++VV+TGAGIST+A IPD+RGPNGVWTL ++G+ +
Sbjct: 77 EVCDDPEELRGKVRELASAVRNAKYLVVYTGAGISTAASIPDYRGPNGVWTLLQKGRSVS 136
Query: 82 INVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDEC 141
++A+PT THM VSQN DGLHL+SG+PR ++ELHGNM+I+ C
Sbjct: 137 A-ADLSEAEPTLTHMSITRLHEQKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVC 195
Query: 142 NIC--KRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCR---GRLYDGVLDW-EHSLPEND 195
C R++VR V V ++ + H TGR C +L D ++ + E
Sbjct: 196 TSCVPNREYVR---VFDVTERTA----LHRHQTGRTCHKCGTQLRDTIVHFGERGTLGQP 248
Query: 196 L--LMAEWHSSIADLSICLGTTLQIV---PSGNLPLETIKYGGKLVICNLQPTKHDNKAD 250
L A +S AD +CLG++L+++ P + KL I NLQ T D+ A
Sbjct: 249 LNWEAATEAASRADTILCLGSSLKVLKKYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAA 308
Query: 251 LLINYYVDDVLEKVMDILGIEIPSYNESENPM 282
L ++ DDV+ +M LG+EIP+Y+ ++P+
Sbjct: 309 LKLHGKCDDVMRLLMAELGLEIPAYSRWQDPI 340
>AF233395-1|AAF43431.1| 400|Homo sapiens sir2-related protein type
7 protein.
Length = 400
Score = 155 bits (377), Expect = 2e-37
Identities = 103/272 (37%), Positives = 154/272 (56%), Gaps = 19/272 (6%)
Query: 22 EKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPT 81
E D ++L K LA V+++K++VV+TGAGIST+A IPD+RGPNGVWTL ++G+ +
Sbjct: 77 EVCDDPEELRGKVRELASAVRNAKYLVVYTGAGISTAASIPDYRGPNGVWTLLQKGRSVS 136
Query: 82 INVSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDEC 141
++A+PT THM VSQN DGLHL+SG+PR ++ELHGNM+I+ C
Sbjct: 137 A-ADLSEAEPTLTHMSITRLHEQKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVC 195
Query: 142 NIC--KRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCR---GRLYDGVLDW-EHSLPEND 195
C R++VR V V ++ + H TGR C +L D ++ + E
Sbjct: 196 TSCVPNREYVR---VFDVTERTA----LHRHQTGRTCHKCGTQLRDTIVHFGERGTLGQP 248
Query: 196 L--LMAEWHSSIADLSICLGTTLQIV---PSGNLPLETIKYGGKLVICNLQPTKHDNKAD 250
L A +S AD +CLG++L+++ P + KL I NLQ T D+ A
Sbjct: 249 LNWEAATEAASRADTILCLGSSLKVLKKYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAA 308
Query: 251 LLINYYVDDVLEKVMDILGIEIPSYNESENPM 282
L ++ DDV+ +M LG+EIP+Y+ ++P+
Sbjct: 309 LKLHGKCDDVMRLLMAELGLEIPAYSRWQDPI 340
>AC005620-2|AAC34468.1| 121|Homo sapiens R33590_2, partial CDS
protein.
Length = 121
Score = 98.3 bits (234), Expect = 4e-20
Identities = 47/70 (67%), Positives = 54/70 (77%)
Query: 176 CRGRLYDGVLDWEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKL 235
CRG L D +LDWE SLP+ DL +A+ S ADLSI LGT+LQI PSGNLPL T + GG+L
Sbjct: 47 CRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRL 106
Query: 236 VICNLQPTKH 245
VI NLQPTKH
Sbjct: 107 VIVNLQPTKH 116
>BC000090-1|AAH00090.1| 191|Homo sapiens Unknown (protein for
IMAGE:3504121) protein.
Length = 191
Score = 91.1 bits (216), Expect = 6e-18
Identities = 46/98 (46%), Positives = 58/98 (59%), Gaps = 3/98 (3%)
Query: 117 GLHLKSGVP--RKFLAELHGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTG- 173
G+ SG+P R LAELHGNMF++EC CK Q+VR + V T+G K +G C G
Sbjct: 58 GISTASGIPDFRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGL 117
Query: 174 RPCRGRLYDGVLDWEHSLPENDLLMAEWHSSIADLSIC 211
R CRG L D +LDWE SLP+ DL +A+ S C
Sbjct: 118 RACRGELRDTILDWEDSLPDRDLALADEASRSGPAGTC 155
Score = 81.8 bits (193), Expect = 4e-15
Identities = 39/65 (60%), Positives = 49/65 (75%)
Query: 1 MSCNYAEGLSPYENKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAG 60
MS NYA GLSPY +KG G+PE FD ++L +K LA+LV S ++V HTGAGIST++G
Sbjct: 5 MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSNVVFHTGAGISTASG 64
Query: 61 IPDFR 65
IPDFR
Sbjct: 65 IPDFR 69
>AK002027-1|BAA92044.1| 183|Homo sapiens protein ( Homo sapiens
cDNA FLJ11165 fis, clone PLACE1007238. ).
Length = 183
Score = 79.0 bits (186), Expect = 2e-14
Identities = 37/75 (49%), Positives = 54/75 (72%), Gaps = 1/75 (1%)
Query: 22 EKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPT 81
E D ++L K LA V+++K++VV+TGAGIST+A IPD+RGPNGVWTL ++G+ +
Sbjct: 77 EVCDDPEELRGKVRELASAVRNAKYLVVYTGAGISTAASIPDYRGPNGVWTLLQKGRSVS 136
Query: 82 INVSFADAQPTKTHM 96
++A+PT THM
Sbjct: 137 A-ADLSEAEPTLTHM 150
>BC001042-1|AAH01042.1| 399|Homo sapiens sirtuin (silent mating
type information regulation 2 homolog) 3 (S. cerevisiae)
protein.
Length = 399
Score = 61.3 bits (142), Expect = 5e-09
Identities = 63/224 (28%), Positives = 95/224 (42%), Gaps = 35/224 (15%)
Query: 26 SNDKLNQKCVLLAQLVKDS--KHIVVHTGAGISTSAGIPDFRGP-NGVWTLEKEGKKPTI 82
S+DK +A+L++ + +VV GAGIST +GIPDFR P +G+++ ++ P
Sbjct: 117 SSDKGKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYP 176
Query: 83 NVSF---------------------ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLK 121
F + +P TH +QNIDGL
Sbjct: 177 EAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERV 236
Query: 122 SGVPRKFLAELHGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRP-CRGRL 180
SG+P L E HG C +C+R F P E + A V P C G +
Sbjct: 237 SGIPASKLVEAHGTFASATCTVCQRPF----PGEDI-----RADVMADRVPRCPVCTGVV 287
Query: 181 YDGVLDWEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNL 224
++ + LP+ LL +ADL + LGT+L++ P +L
Sbjct: 288 KPDIVFFGEPLPQRFLLHVV-DFPMADLLLILGTSLEVEPFASL 330
>AF083108-1|AAD40851.1| 399|Homo sapiens sirtuin type 3 protein.
Length = 399
Score = 61.3 bits (142), Expect = 5e-09
Identities = 63/224 (28%), Positives = 95/224 (42%), Gaps = 35/224 (15%)
Query: 26 SNDKLNQKCVLLAQLVKDS--KHIVVHTGAGISTSAGIPDFRGP-NGVWTLEKEGKKPTI 82
S+DK +A+L++ + +VV GAGIST +GIPDFR P +G+++ ++ P
Sbjct: 117 SSDKGKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYP 176
Query: 83 NVSF---------------------ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLK 121
F + +P TH +QNIDGL
Sbjct: 177 EAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERV 236
Query: 122 SGVPRKFLAELHGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRP-CRGRL 180
SG+P L E HG C +C+R F P E + A V P C G +
Sbjct: 237 SGIPASKLVEAHGTFASATCTVCQRPF----PGEDI-----RADVMADRVPRCPVCTGVV 287
Query: 181 YDGVLDWEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNL 224
++ + LP+ LL +ADL + LGT+L++ P +L
Sbjct: 288 KPDIVFFGEPLPQRFLLHVV-DFPMADLLLILGTSLEVEPFASL 330
>BC012499-1|AAH12499.1| 555|Homo sapiens SIRT1 protein protein.
Length = 555
Score = 56.0 bits (129), Expect = 2e-07
Identities = 58/234 (24%), Positives = 96/234 (41%), Gaps = 37/234 (15%)
Query: 39 QLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT-----------------LEKEGKKPT 81
+L+++ K I+V TGAG+S S GIPDFR +G++ +E K P
Sbjct: 56 KLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPR 115
Query: 82 INVSFA------DAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGN 135
FA QP+ H +QNID L +G+ R + + HG+
Sbjct: 116 PFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQR--IIQCHGS 173
Query: 136 MFIDECNICKR----QFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSL 191
C ICK + VR + V +C P +P ++ + +L
Sbjct: 174 FATASCLICKYKVDCEAVRGALFSQVVPRCPRCPADEPLAIMKP-------EIVFFGENL 226
Query: 192 PENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKH 245
PE ++ DL I +G++L++ P +P +I + ++ N +P H
Sbjct: 227 PEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIP-SSIPHEVPQILINREPLPH 279
>DQ278604-1|ABB72675.1| 747|Homo sapiens sirtuin (silent mating
type information regulation 2 homolog) 1 (S. cerevisiae)
protein.
Length = 747
Score = 55.6 bits (128), Expect = 3e-07
Identities = 58/234 (24%), Positives = 95/234 (40%), Gaps = 37/234 (15%)
Query: 39 QLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT-----------------LEKEGKKPT 81
+L+++ K I+V TGAG+S S GIPDFR +G++ +E K P
Sbjct: 248 KLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPR 307
Query: 82 INVSFA------DAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGN 135
FA QP+ H +QNID L +G+ R + + HG+
Sbjct: 308 PFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQR--IIQCHGS 365
Query: 136 MFIDECNICKR----QFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSL 191
C ICK + VR V +C P +P ++ + +L
Sbjct: 366 FATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKP-------EIVFFGENL 418
Query: 192 PENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKH 245
PE ++ DL I +G++L++ P +P +I + ++ N +P H
Sbjct: 419 PEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIP-SSIPHEVPQILINREPLPH 471
>AL133551-8|CAI16036.1| 747|Homo sapiens sirtuin (silent mating
type information regulation 2 homolog) 1 (S. cerevisiae)
protein.
Length = 747
Score = 55.6 bits (128), Expect = 3e-07
Identities = 58/234 (24%), Positives = 95/234 (40%), Gaps = 37/234 (15%)
Query: 39 QLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT-----------------LEKEGKKPT 81
+L+++ K I+V TGAG+S S GIPDFR +G++ +E K P
Sbjct: 248 KLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPR 307
Query: 82 INVSFA------DAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGN 135
FA QP+ H +QNID L +G+ R + + HG+
Sbjct: 308 PFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQR--IIQCHGS 365
Query: 136 MFIDECNICKR----QFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSL 191
C ICK + VR V +C P +P ++ + +L
Sbjct: 366 FATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKP-------EIVFFGENL 418
Query: 192 PENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKH 245
PE ++ DL I +G++L++ P +P +I + ++ N +P H
Sbjct: 419 PEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIP-SSIPHEVPQILINREPLPH 471
>AF235040-1|AAG38486.1| 747|Homo sapiens SIR2alpha protein protein.
Length = 747
Score = 55.6 bits (128), Expect = 3e-07
Identities = 58/234 (24%), Positives = 95/234 (40%), Gaps = 37/234 (15%)
Query: 39 QLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT-----------------LEKEGKKPT 81
+L+++ K I+V TGAG+S S GIPDFR +G++ +E K P
Sbjct: 248 KLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPR 307
Query: 82 INVSFA------DAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGN 135
FA QP+ H +QNID L +G+ R + + HG+
Sbjct: 308 PFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQR--IIQCHGS 365
Query: 136 MFIDECNICKR----QFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSL 191
C ICK + VR V +C P +P ++ + +L
Sbjct: 366 FATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKP-------EIVFFGENL 418
Query: 192 PENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKH 245
PE ++ DL I +G++L++ P +P +I + ++ N +P H
Sbjct: 419 PEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIP-SSIPHEVPQILINREPLPH 471
>AF083106-1|AAD40849.2| 747|Homo sapiens sirtuin type 1 protein.
Length = 747
Score = 55.6 bits (128), Expect = 3e-07
Identities = 58/234 (24%), Positives = 95/234 (40%), Gaps = 37/234 (15%)
Query: 39 QLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT-----------------LEKEGKKPT 81
+L+++ K I+V TGAG+S S GIPDFR +G++ +E K P
Sbjct: 248 KLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPR 307
Query: 82 INVSFA------DAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGN 135
FA QP+ H +QNID L +G+ R + + HG+
Sbjct: 308 PFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQR--IIQCHGS 365
Query: 136 MFIDECNICKR----QFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSL 191
C ICK + VR V +C P +P ++ + +L
Sbjct: 366 FATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKP-------EIVFFGENL 418
Query: 192 PENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKH 245
PE ++ DL I +G++L++ P +P +I + ++ N +P H
Sbjct: 419 PEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIP-SSIPHEVPQILINREPLPH 471
>AK131484-1|BAD18629.1| 162|Homo sapiens protein ( Homo sapiens
cDNA FLJ16662 fis, clone TESTI4046240, highly similar
to Homo sapiens sirtuin 7 (SIRT7). ).
Length = 162
Score = 50.0 bits (114), Expect = 1e-05
Identities = 20/29 (68%), Positives = 26/29 (89%)
Query: 111 VSQNIDGLHLKSGVPRKFLAELHGNMFID 139
VSQN DGLHL+SG+PR ++ELHGNM+I+
Sbjct: 16 VSQNCDGLHLRSGLPRTAISELHGNMYIE 44
>BC109320-1|AAI09321.1| 314|Homo sapiens sirtuin (silent mating
type information regulation 2 homolog) 4 (S. cerevisiae)
protein.
Length = 314
Score = 46.0 bits (104), Expect = 2e-04
Identities = 42/140 (30%), Positives = 57/140 (40%), Gaps = 24/140 (17%)
Query: 32 QKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTIN-------- 83
+K L + + SK ++V TGAGIST +GIPD+R V + ++P +
Sbjct: 42 EKVKELQRFITLSKRLLVMTGAGISTESGIPDYRSEK-VGLYARTDRRPIQHGDFVRSAP 100
Query: 84 -------------VSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLA 130
F+ QP H V+QN+D LH K+G R L
Sbjct: 101 IRQRYWARNFVGWPQFSSHQPNPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRR--LT 158
Query: 131 ELHGNMFIDECNICKRQFVR 150
ELHG M C C Q R
Sbjct: 159 ELHGCMDRVLCLDCGEQTPR 178
>BC109319-1|AAI09320.1| 314|Homo sapiens sirtuin (silent mating
type information regulation 2 homolog) 4 (S. cerevisiae)
protein.
Length = 314
Score = 46.0 bits (104), Expect = 2e-04
Identities = 42/140 (30%), Positives = 57/140 (40%), Gaps = 24/140 (17%)
Query: 32 QKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTIN-------- 83
+K L + + SK ++V TGAGIST +GIPD+R V + ++P +
Sbjct: 42 EKVKELQRFITLSKRLLVMTGAGISTESGIPDYRSEK-VGLYARTDRRPIQHGDFVRSAP 100
Query: 84 -------------VSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLA 130
F+ QP H V+QN+D LH K+G R L
Sbjct: 101 IRQRYWARNFVGWPQFSSHQPNPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRR--LT 158
Query: 131 ELHGNMFIDECNICKRQFVR 150
ELHG M C C Q R
Sbjct: 159 ELHGCMDRVLCLDCGEQTPR 178
>AF083109-1|AAD40852.1| 314|Homo sapiens sirtuin type 4 protein.
Length = 314
Score = 46.0 bits (104), Expect = 2e-04
Identities = 42/140 (30%), Positives = 57/140 (40%), Gaps = 24/140 (17%)
Query: 32 QKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTIN-------- 83
+K L + + SK ++V TGAGIST +GIPD+R V + ++P +
Sbjct: 42 EKVKELQRFITLSKRLLVMTGAGISTESGIPDYRSEK-VGLYARTDRRPIQHGDFVRSAP 100
Query: 84 -------------VSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLA 130
F+ QP H V+QN+D LH K+G R L
Sbjct: 101 IRQRYWARNFVGWPQFSSHQPNPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRR--LT 158
Query: 131 ELHGNMFIDECNICKRQFVR 150
ELHG M C C Q R
Sbjct: 159 ELHGCMDRVLCLDCGEQTPR 178
>AJ505014-1|CAD43717.1| 369|Homo sapiens sirtuin type 2 protein.
Length = 369
Score = 45.6 bits (103), Expect = 3e-04
Identities = 50/204 (24%), Positives = 84/204 (41%), Gaps = 32/204 (15%)
Query: 45 KHIVVHTGAGISTSAGIPDFRGPN-GVW-TLEK---EGKKPTINVSF------------- 86
+ ++ GAGISTSAGIPDFR P+ G++ LEK + +S+
Sbjct: 57 RRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAK 116
Query: 87 ----ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDEC- 141
+PT H +QNID L +G+ ++ L E HG + C
Sbjct: 117 ELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCV 176
Query: 142 -NICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAE 200
C+ ++ S E + + + + C C+ + ++ + SLP +
Sbjct: 177 SASCRHEYPLSWMKEKIFSEVT-LKC-------EDCQSLVKPDIVFFGESLPARFFSCMQ 228
Query: 201 WHSSIADLSICLGTTLQIVPSGNL 224
DL + +GT+LQ+ P +L
Sbjct: 229 SDFLKVDLLLVMGTSLQVQPFASL 252
>AC003982-1|AAB95634.1| 326|Homo sapiens WUGSC:H_166H1.1 protein.
Length = 326
Score = 45.6 bits (103), Expect = 3e-04
Identities = 39/133 (29%), Positives = 56/133 (42%), Gaps = 24/133 (18%)
Query: 32 QKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTIN-------- 83
+K L + + SK ++V TGAGIST +GIPD+R V + ++P +
Sbjct: 42 EKVKELQRFITLSKRLLVMTGAGISTESGIPDYRSEK-VGLYARTDRRPIQHGDFVRSAP 100
Query: 84 -------------VSFADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLA 130
F+ QP H V+QN+D LH K+G R L
Sbjct: 101 IRQRYWARNFVGWPQFSSHQPNPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRR--LT 158
Query: 131 ELHGNMFIDECNI 143
ELHG M C++
Sbjct: 159 ELHGCMDRAYCSV 171
>BC003547-1|AAH03547.1| 352|Homo sapiens sirtuin (silent mating
type information regulation 2 homolog) 2 (S. cerevisiae)
protein.
Length = 352
Score = 44.4 bits (100), Expect = 7e-04
Identities = 50/204 (24%), Positives = 83/204 (40%), Gaps = 32/204 (15%)
Query: 45 KHIVVHTGAGISTSAGIPDFRGPN-GVW-TLEK---EGKKPTINVSF------------- 86
+ ++ GAGISTSAGIPDFR P+ G++ LEK + +S+
Sbjct: 40 RRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAK 99
Query: 87 ----ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDEC- 141
+PT H +QNID L +G+ ++ L E HG + C
Sbjct: 100 ELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCV 159
Query: 142 -NICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAE 200
C+ ++ S E + + + C C+ + ++ + SLP +
Sbjct: 160 SASCRHEYPLSWMKEKIFSEVT-PKC-------EDCQSLVKPDIVFFGESLPARFFSCMQ 211
Query: 201 WHSSIADLSICLGTTLQIVPSGNL 224
DL + +GT+LQ+ P +L
Sbjct: 212 SDFLKVDLLLVMGTSLQVQPFASL 235
>BC003012-1|AAH03012.1| 352|Homo sapiens sirtuin (silent mating
type information regulation 2 homolog) 2 (S. cerevisiae)
protein.
Length = 352
Score = 44.4 bits (100), Expect = 7e-04
Identities = 50/204 (24%), Positives = 83/204 (40%), Gaps = 32/204 (15%)
Query: 45 KHIVVHTGAGISTSAGIPDFRGPN-GVW-TLEK---EGKKPTINVSF------------- 86
+ ++ GAGISTSAGIPDFR P+ G++ LEK + +S+
Sbjct: 40 RRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAK 99
Query: 87 ----ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDEC- 141
+PT H +QNID L +G+ ++ L E HG + C
Sbjct: 100 ELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCV 159
Query: 142 -NICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAE 200
C+ ++ S E + + + C C+ + ++ + SLP +
Sbjct: 160 SASCRHEYPLSWMKEKIFSEVT-PKC-------EDCQSLVKPDIVFFGESLPARFFSCMQ 211
Query: 201 WHSSIADLSICLGTTLQIVPSGNL 224
DL + +GT+LQ+ P +L
Sbjct: 212 SDFLKVDLLLVMGTSLQVQPFASL 235
>AY030277-1|AAK51133.1| 352|Homo sapiens SIRT2 protein.
Length = 352
Score = 44.4 bits (100), Expect = 7e-04
Identities = 50/204 (24%), Positives = 83/204 (40%), Gaps = 32/204 (15%)
Query: 45 KHIVVHTGAGISTSAGIPDFRGPN-GVW-TLEK---EGKKPTINVSF------------- 86
+ ++ GAGISTSAGIPDFR P+ G++ LEK + +S+
Sbjct: 40 RRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAK 99
Query: 87 ----ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDEC- 141
+PT H +QNID L +G+ ++ L E HG + C
Sbjct: 100 ELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCV 159
Query: 142 -NICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAE 200
C+ ++ S E + + + C C+ + ++ + SLP +
Sbjct: 160 SASCRHEYPLSWMKEKIFSEVT-PKC-------EDCQSLVKPDIVFFGESLPARFFSCMQ 211
Query: 201 WHSSIADLSICLGTTLQIVPSGNL 224
DL + +GT+LQ+ P +L
Sbjct: 212 SDFLKVDLLLVMGTSLQVQPFASL 235
>AF095714-1|AAD45971.1| 352|Homo sapiens silencing information
regulator 2-like protein protein.
Length = 352
Score = 44.4 bits (100), Expect = 7e-04
Identities = 50/204 (24%), Positives = 83/204 (40%), Gaps = 32/204 (15%)
Query: 45 KHIVVHTGAGISTSAGIPDFRGPN-GVW-TLEK---EGKKPTINVSF------------- 86
+ ++ GAGISTSAGIPDFR P+ G++ LEK + +S+
Sbjct: 40 RRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAK 99
Query: 87 ----ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDEC- 141
+PT H +QNID L +G+ ++ L E HG + C
Sbjct: 100 ELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCV 159
Query: 142 -NICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAE 200
C+ ++ S E + + + C C+ + ++ + SLP +
Sbjct: 160 SASCRHEYPLSWMKEKIFSEVT-PKC-------EDCQSLVKPDIVFFGESLPARFFSCMQ 211
Query: 201 WHSSIADLSICLGTTLQIVPSGNL 224
DL + +GT+LQ+ P +L
Sbjct: 212 SDFLKVDLLLVMGTSLQVQPFASL 235
>AF083107-1|AAD40850.2| 389|Homo sapiens sirtuin type 2 protein.
Length = 389
Score = 44.4 bits (100), Expect = 7e-04
Identities = 50/204 (24%), Positives = 83/204 (40%), Gaps = 32/204 (15%)
Query: 45 KHIVVHTGAGISTSAGIPDFRGPN-GVW-TLEK---EGKKPTINVSF------------- 86
+ ++ GAGISTSAGIPDFR P+ G++ LEK + +S+
Sbjct: 77 RRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAK 136
Query: 87 ----ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDEC- 141
+PT H +QNID L +G+ ++ L E HG + C
Sbjct: 137 ELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCV 196
Query: 142 -NICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAE 200
C+ ++ S E + + + C C+ + ++ + SLP +
Sbjct: 197 SASCRHEYPLSWMKEKIFSEVT-PKC-------EDCQSLVKPDIVFFGESLPARFFSCMQ 248
Query: 201 WHSSIADLSICLGTTLQIVPSGNL 224
DL + +GT+LQ+ P +L
Sbjct: 249 SDFLKVDLLLVMGTSLQVQPFASL 272
>BC000126-1|AAH00126.1| 310|Homo sapiens sirtuin (silent mating
type information regulation 2 homolog) 5 (S.
cerevisiae) protein.
Length = 310
Score = 41.9 bits (94), Expect = 0.003
Identities = 15/28 (53%), Positives = 21/28 (75%)
Query: 44 SKHIVVHTGAGISTSAGIPDFRGPNGVW 71
+KHIV+ +GAG+S +G+P FRG G W
Sbjct: 50 AKHIVIISGAGVSAESGVPTFRGAGGYW 77
Score = 35.9 bits (79), Expect = 0.23
Identities = 16/34 (47%), Positives = 22/34 (64%), Gaps = 2/34 (5%)
Query: 111 VSQNIDGLHLKSGVPRKFLAELHGNMFIDECNIC 144
++QNID LH K+G K L E+HG++F C C
Sbjct: 138 ITQNIDELHRKAGT--KNLLEIHGSLFKTRCTSC 169
>AL441883-2|CAI19838.1| 310|Homo sapiens sirtuin (silent mating
type information regulation 2 homolog) 5 (S.
cerevisiae) protein.
Length = 310
Score = 41.9 bits (94), Expect = 0.003
Identities = 15/28 (53%), Positives = 21/28 (75%)
Query: 44 SKHIVVHTGAGISTSAGIPDFRGPNGVW 71
+KHIV+ +GAG+S +G+P FRG G W
Sbjct: 50 AKHIVIISGAGVSAESGVPTFRGAGGYW 77
Score = 35.9 bits (79), Expect = 0.23
Identities = 16/34 (47%), Positives = 22/34 (64%), Gaps = 2/34 (5%)
Query: 111 VSQNIDGLHLKSGVPRKFLAELHGNMFIDECNIC 144
++QNID LH K+G K L E+HG++F C C
Sbjct: 138 ITQNIDELHRKAGT--KNLLEIHGSLFKTRCTSC 169
>AL441883-1|CAI19837.1| 299|Homo sapiens sirtuin (silent mating
type information regulation 2 homolog) 5 (S.
cerevisiae) protein.
Length = 299
Score = 41.9 bits (94), Expect = 0.003
Identities = 15/28 (53%), Positives = 21/28 (75%)
Query: 44 SKHIVVHTGAGISTSAGIPDFRGPNGVW 71
+KHIV+ +GAG+S +G+P FRG G W
Sbjct: 50 AKHIVIISGAGVSAESGVPTFRGAGGYW 77
Score = 35.9 bits (79), Expect = 0.23
Identities = 16/34 (47%), Positives = 22/34 (64%), Gaps = 2/34 (5%)
Query: 111 VSQNIDGLHLKSGVPRKFLAELHGNMFIDECNIC 144
++QNID LH K+G K L E+HG++F C C
Sbjct: 138 ITQNIDELHRKAGT--KNLLEIHGSLFKTRCTSC 169
>AK000355-1|BAA91107.1| 299|Homo sapiens protein ( Homo sapiens
cDNA FLJ20348 fis, clone HEP13915. ).
Length = 299
Score = 41.9 bits (94), Expect = 0.003
Identities = 15/28 (53%), Positives = 21/28 (75%)
Query: 44 SKHIVVHTGAGISTSAGIPDFRGPNGVW 71
+KHIV+ +GAG+S +G+P FRG G W
Sbjct: 50 AKHIVIISGAGVSAESGVPTFRGAGGYW 77
Score = 35.9 bits (79), Expect = 0.23
Identities = 16/34 (47%), Positives = 22/34 (64%), Gaps = 2/34 (5%)
Query: 111 VSQNIDGLHLKSGVPRKFLAELHGNMFIDECNIC 144
++QNID LH K+G K L E+HG++F C C
Sbjct: 138 ITQNIDELHRKAGT--KNLLEIHGSLFKTRCTSC 169
>AF083110-1|AAD40853.1| 310|Homo sapiens sirtuin type 5 protein.
Length = 310
Score = 41.9 bits (94), Expect = 0.003
Identities = 15/28 (53%), Positives = 21/28 (75%)
Query: 44 SKHIVVHTGAGISTSAGIPDFRGPNGVW 71
+KHIV+ +GAG+S +G+P FRG G W
Sbjct: 50 AKHIVIISGAGVSAESGVPTFRGAGGYW 77
Score = 35.9 bits (79), Expect = 0.23
Identities = 16/34 (47%), Positives = 22/34 (64%), Gaps = 2/34 (5%)
Query: 111 VSQNIDGLHLKSGVPRKFLAELHGNMFIDECNIC 144
++QNID LH K+G K L E+HG++F C C
Sbjct: 138 ITQNIDELHRKAGT--KNLLEIHGSLFKTRCTSC 169
>AK131437-1|BAD18583.1| 164|Homo sapiens protein ( Homo sapiens
cDNA FLJ16567 fis, clone TBAES2000932, highly similar
to Homo sapiens sirtuin 7 (SIRT7). ).
Length = 164
Score = 41.1 bits (92), Expect = 0.006
Identities = 21/49 (42%), Positives = 32/49 (65%)
Query: 234 KLVICNLQPTKHDNKADLLINYYVDDVLEKVMDILGIEIPSYNESENPM 282
KL I NLQ T D+ A L ++ DDV+ +M LG+EIP+Y+ ++P+
Sbjct: 56 KLYIVNLQWTPKDDWAALKLHGKCDDVMRLLMAELGLEIPAYSRWQDPI 104
>AF131800-1|AAD20046.1| 254|Homo sapiens Similar to rat 5E5 antigen
protein.
Length = 254
Score = 39.9 bits (89), Expect = 0.014
Identities = 48/197 (24%), Positives = 79/197 (40%), Gaps = 32/197 (16%)
Query: 45 KHIVVHTGAGISTSAGIPDFRGPN-GVW-TLEK---EGKKPTINVSF------------- 86
+ ++ GAGISTSAGIPDFR P+ G++ LEK + +S+
Sbjct: 60 RRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAK 119
Query: 87 ----ADAQPTKTHMXXXXXXXXXXXXXXVSQNIDGLHLKSGVPRKFLAELHGNMFIDEC- 141
+PT H +QNID L +G+ ++ L E HG + C
Sbjct: 120 ELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCV 179
Query: 142 -NICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAE 200
C+ ++ S E + + + C C+ + ++ + SLP +
Sbjct: 180 SASCRHEYPLSWMKEKIFSEVT-PKC-------EDCQSLVKPDIVFFGESLPARFFSCMQ 231
Query: 201 WHSSIADLSICLGTTLQ 217
DL + +GT+LQ
Sbjct: 232 SDFLKVDLLLVMGTSLQ 248
>AF160214-1|AAF67015.1| 373|Homo sapiens silent information
regulator 2 homolog protein.
Length = 373
Score = 37.9 bits (84), Expect = 0.057
Identities = 19/33 (57%), Positives = 25/33 (75%), Gaps = 2/33 (6%)
Query: 45 KHIVVHTGAGISTSAGIPDFRGPN-GVW-TLEK 75
+ ++ GAGISTSAGIPDFR P+ G++ LEK
Sbjct: 61 RRVICLVGAGISTSAGIPDFRSPSTGLYDNLEK 93
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.316 0.135 0.404
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 54,576,692
Number of Sequences: 224733
Number of extensions: 2326517
Number of successful extensions: 4960
Number of sequences better than 10.0: 40
Number of HSP's better than 10.0 without gapping: 40
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 4875
Number of HSP's gapped (non-prelim): 63
length of query: 370
length of database: 73,234,838
effective HSP length: 91
effective length of query: 279
effective length of database: 52,784,135
effective search space: 14726773665
effective search space used: 14726773665
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.6 bits)
S2: 66 (30.7 bits)
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