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Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= BGIBMGA001371-TA|BGIBMGA001371-PA|IPR002558|I/LWEQ
         (697 letters)

Database: human 
           224,733 sequences; 73,234,838 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

BC042923-1|AAH42923.1| 2541|Homo sapiens talin 1 protein.             260   9e-69
AL133410-5|CAI10978.1| 2429|Homo sapiens talin 1 protein.             260   9e-69
AF178534-1|AAF27330.1| 2540|Homo sapiens talin protein.               260   9e-69
AB028950-1|BAA82979.2| 2550|Homo sapiens KIAA1027 protein protein.    260   9e-69
AF402000-1|AAM73764.1| 2542|Homo sapiens talin 2 protein.             258   6e-68
AF177198-1|AAF23322.1| 2541|Homo sapiens talin protein.               258   6e-68
AF078828-1|AAD13152.1| 2541|Homo sapiens talin protein.               258   6e-68
AB002318-1|BAA20778.2| 1933|Homo sapiens KIAA0320 protein.            258   6e-68
BX538132-1|CAD98033.1|  965|Homo sapiens hypothetical protein pr...    33   2.6  
BC125236-1|AAI25237.1|  473|Homo sapiens ANK2 protein protein.         33   2.6  
BC125235-1|AAI25236.1|  555|Homo sapiens ANK2 protein protein.         33   2.6  
AL121586-4|CAB89415.1| 2442|Homo sapiens centrosomal protein 250...    33   3.4  
AF049105-1|AAC07988.1| 2442|Homo sapiens centrosomal Nek2-associ...    33   3.4  
AF022655-1|AAC06349.1| 2442|Homo sapiens cep250 centrosome assoc...    33   3.4  
Z29064-1|CAA82305.1|  896|Homo sapiens AF-1p protein.                  32   6.0  
U07707-1|AAA52101.1|  896|Homo sapiens epidermal growth factor r...    32   6.0  
L14565-1|AAA60190.1|  471|Homo sapiens peripherin protein.             32   6.0  
DQ367924-1|ABD34786.1|  896|Homo sapiens epidermal growth factor...    32   6.0  
BC032703-1|AAH32703.1|  470|Homo sapiens peripherin protein.           32   6.0  
AY358830-1|AAQ89189.1|  723|Homo sapiens leucine-rich protein pr...    32   6.0  
AL671986-11|CAI13030.1|  896|Homo sapiens epidermal growth facto...    32   6.0  
AL445222-17|CAH72930.1|  723|Homo sapiens leucine rich repeat an...    32   6.0  
AL445222-16|CAH72931.1|  696|Homo sapiens leucine rich repeat an...    32   6.0  
AK091589-1|BAC03703.1|  723|Homo sapiens protein ( Homo sapiens ...    32   6.0  
BC009239-1|AAH09239.1|  723|Homo sapiens leucine rich repeat and...    32   7.9  
AK056203-1|BAB71119.1|  696|Homo sapiens protein ( Homo sapiens ...    32   7.9  

>BC042923-1|AAH42923.1| 2541|Homo sapiens talin 1 protein.
          Length = 2541

 Score =  260 bits (638), Expect = 9e-69
 Identities = 156/423 (36%), Positives = 234/423 (55%), Gaps = 8/423 (1%)

Query: 6    DILLSLAKAVANTTXXXXXXXXXXXXQCRDDQQLQNNIIAAATHCALATSQLVACAKVVA 65
            D L+ LAKAVA+              Q  +D  LQ  +IAAAT CAL+TSQLVAC KVVA
Sbjct: 666  DALMQLAKAVASAAAALVLKAKSVA-QRTEDSGLQTQVIAAATQCALSTSQLVACTKVVA 724

Query: 66   PTLHSAACREQLTSAARQVAQAVDRLVEXXXXXXXXXXXXXXXXXXXXHCVSEELERLLA 125
            PT+ S  C+EQL  A R VA+AV+  V                       V++ L  LL 
Sbjct: 725  PTISSPVCQEQLVEAGRLVAKAVEGCVSASQAATEDGQLLRGVGAAAT-AVTQALNELLQ 783

Query: 126  HCQXXXXXX--XXXXXXXXXXXXXXHERLLAAAGPA-DMLRHARQLGHATALLITNIKTE 182
            H +                       E + ++ G A +M+R AR L  AT+ L+  IK +
Sbjct: 784  HVKAHATGAGPAGRYDQATDTILTVTENIFSSMGDAGEMVRQARILAQATSDLVNAIKAD 843

Query: 183  AE-ESPSDSQRXXXXXXXXXXDATARMVEAARQCASSPQDREKQEVLRKAAEELRFITAD 241
            AE ES  ++ R          DATA+MVEAA+  A+ P   E+Q+ LR+AAE LR  T  
Sbjct: 844  AEGESDLENSRKLLSAAKILADATAKMVEAAKGAAAHPDSEEQQQRLREAAEGLRMATNA 903

Query: 242  YAQGQDIVGSQVARLQESARQATSSATQLITSAQNATQY-NTNRYSQETLLEECKVLNEH 300
             AQ   I    V RL+ +A+QA +SATQ I +AQ+A      +   Q  L++ CK + E 
Sbjct: 904  AAQNA-IKKKLVQRLEHAAKQAAASATQTIAAAQHAASTPKASAGPQPLLVQSCKAVAEQ 962

Query: 301  LPRMVEAVNVSNVKPTQAAARLDLISASEAFLQPSGHVISAARGALPTVSEPSAAKHLAD 360
            +P +V+ V  S  +P   +A+L LI+AS++FLQP G +++AA+ ++PT+ + ++A  L+ 
Sbjct: 963  IPLLVQGVRGSQAQPDSPSAQLALIAASQSFLQPGGKMVAAAKASVPTIQDQASAMQLSQ 1022

Query: 361  NTQLYTSSCADLRSAVSRARISCKGLELDAAAEIIKSLQEELDELEEAVRAFDLKPLPGQ 420
              +   ++ A+LR+A  +A+ +C  LE+D+A  ++++L+++L E++ A R   LKPLPG+
Sbjct: 1023 CAKNLGTALAELRTAAQKAQEACGPLEMDSALSVVQNLEKDLQEVKAAARDGKLKPLPGE 1082

Query: 421  TAE 423
            T E
Sbjct: 1083 TME 1085



 Score =  179 bits (436), Expect = 3e-44
 Identities = 94/256 (36%), Positives = 145/256 (56%), Gaps = 2/256 (0%)

Query: 444  VVISSGRQVLYSSLTLVETVKKQISSSEQVDSAA-LASIAKDITHGLEQTMEAVPSHTEL 502
            +V+ +   VL  + +L+E  KK        +S   LA +AK +T  L + +  +P   ++
Sbjct: 1150 IVLDTASDVLDKASSLIEEAKKAAGHPGDPESQQRLAQVAKAVTQALNRCVSCLPGQRDV 1209

Query: 503  DLAMENINETLNILNMGEFPPTDSSYGELQVXXXXXXXXXXXXXXXXXXXX-DDPRTLAD 561
            D A+  + +    L     PP+  ++ E Q                        P+ LA 
Sbjct: 1210 DNALRAVGDASKRLLSDSLPPSTGTFQEAQSRLNEAAAGLNQAATELVQASRGTPQDLAR 1269

Query: 562  SSHSFGQAFNNLLGVGMEMAGQTEDRETQSLMVNSMKSVTVNSSKLLGTAKSVSQDLSRP 621
            +S  FGQ F+  L  G+EMAGQ   +E ++ +V+++K ++++SSKLL  AK++S D + P
Sbjct: 1270 ASGRFGQDFSTFLEAGVEMAGQAPSQEDRAQVVSNLKGISMSSSKLLLAAKALSTDPAAP 1329

Query: 622  NAKNQLTAAARAVTDSINKLVDACTQAAPGHKACGAARRSVQAARPLLDAPAQPLSDLSY 681
            N K+QL AAARAVTDSIN+L+  CTQ APG K C  A R ++  R LL+ P QP++D+SY
Sbjct: 1330 NLKSQLAAAARAVTDSINQLITMCTQQAPGQKECDNALRELETVRELLENPVQPINDMSY 1389

Query: 682  FACLDAVLDHSKQLSE 697
            F CLD+V+++SK L E
Sbjct: 1390 FGCLDSVMENSKVLGE 1405



 Score = 39.9 bits (89), Expect = 0.030
 Identities = 24/86 (27%), Positives = 44/86 (51%)

Query: 585  EDRETQSLMVNSMKSVTVNSSKLLGTAKSVSQDLSRPNAKNQLTAAARAVTDSINKLVDA 644
            E R     +V S K++  ++  L+ TA++++ +   P + + L   +R V+DSI KL+ +
Sbjct: 1591 EGRAAMEPIVISAKTMLESAGGLIQTARALAVNPRDPPSWSVLAGHSRTVSDSIKKLITS 1650

Query: 645  CTQAAPGHKACGAARRSVQAARPLLD 670
                APG   C  A  ++ +    LD
Sbjct: 1651 MRDKAPGQLECETAIAALNSCLRDLD 1676



 Score = 34.3 bits (75), Expect = 1.5
 Identities = 34/115 (29%), Positives = 57/115 (49%), Gaps = 8/115 (6%)

Query: 555 DPR-TLADSSHSFGQAFNNLLGVGMEMAGQTE-DRETQSLMVNSMKSVTVNSSKLLGTAK 612
           +PR  L  ++ + GQA   LL    +  G+++ D   Q  ++   K+V   ++ L+  AK
Sbjct: 632 EPRQNLLQAAGNVGQASGELL----QQIGESDTDPHFQDALMQLAKAVASAAAALVLKAK 687

Query: 613 SVSQDLSRPNAKNQLTAAARAVTDSINKLVDACTQ-AAPGHKACGAARRSVQAAR 666
           SV+Q       + Q+ AAA     S ++LV ACT+  AP   +     + V+A R
Sbjct: 688 SVAQRTEDSGLQTQVIAAATQCALSTSQLV-ACTKVVAPTISSPVCQEQLVEAGR 741


>AL133410-5|CAI10978.1| 2429|Homo sapiens talin 1 protein.
          Length = 2429

 Score =  260 bits (638), Expect = 9e-69
 Identities = 156/423 (36%), Positives = 234/423 (55%), Gaps = 8/423 (1%)

Query: 6    DILLSLAKAVANTTXXXXXXXXXXXXQCRDDQQLQNNIIAAATHCALATSQLVACAKVVA 65
            D L+ LAKAVA+              Q  +D  LQ  +IAAAT CAL+TSQLVAC KVVA
Sbjct: 666  DALMQLAKAVASAAAALVLKAKSVA-QRTEDSGLQTQVIAAATQCALSTSQLVACTKVVA 724

Query: 66   PTLHSAACREQLTSAARQVAQAVDRLVEXXXXXXXXXXXXXXXXXXXXHCVSEELERLLA 125
            PT+ S  C+EQL  A R VA+AV+  V                       V++ L  LL 
Sbjct: 725  PTISSPVCQEQLVEAGRLVAKAVEGCVSASQAATEDGQLLRGVGAAAT-AVTQALNELLQ 783

Query: 126  HCQXXXXXX--XXXXXXXXXXXXXXHERLLAAAGPA-DMLRHARQLGHATALLITNIKTE 182
            H +                       E + ++ G A +M+R AR L  AT+ L+  IK +
Sbjct: 784  HVKAHATGAGPAGRYDQATDTILTVTENIFSSMGDAGEMVRQARILAQATSDLVNAIKAD 843

Query: 183  AE-ESPSDSQRXXXXXXXXXXDATARMVEAARQCASSPQDREKQEVLRKAAEELRFITAD 241
            AE ES  ++ R          DATA+MVEAA+  A+ P   E+Q+ LR+AAE LR  T  
Sbjct: 844  AEGESDLENSRKLLSAAKILADATAKMVEAAKGAAAHPDSEEQQQRLREAAEGLRMATNA 903

Query: 242  YAQGQDIVGSQVARLQESARQATSSATQLITSAQNATQY-NTNRYSQETLLEECKVLNEH 300
             AQ   I    V RL+ +A+QA +SATQ I +AQ+A      +   Q  L++ CK + E 
Sbjct: 904  AAQNA-IKKKLVQRLEHAAKQAAASATQTIAAAQHAASTPKASAGPQPLLVQSCKAVAEQ 962

Query: 301  LPRMVEAVNVSNVKPTQAAARLDLISASEAFLQPSGHVISAARGALPTVSEPSAAKHLAD 360
            +P +V+ V  S  +P   +A+L LI+AS++FLQP G +++AA+ ++PT+ + ++A  L+ 
Sbjct: 963  IPLLVQGVRGSQAQPDSPSAQLALIAASQSFLQPGGKMVAAAKASVPTIQDQASAMQLSQ 1022

Query: 361  NTQLYTSSCADLRSAVSRARISCKGLELDAAAEIIKSLQEELDELEEAVRAFDLKPLPGQ 420
              +   ++ A+LR+A  +A+ +C  LE+D+A  ++++L+++L E++ A R   LKPLPG+
Sbjct: 1023 CAKNLGTALAELRTAAQKAQEACGPLEMDSALSVVQNLEKDLQEVKAAARDGKLKPLPGE 1082

Query: 421  TAE 423
            T E
Sbjct: 1083 TME 1085



 Score =  179 bits (436), Expect = 3e-44
 Identities = 94/256 (36%), Positives = 145/256 (56%), Gaps = 2/256 (0%)

Query: 444  VVISSGRQVLYSSLTLVETVKKQISSSEQVDSAA-LASIAKDITHGLEQTMEAVPSHTEL 502
            +V+ +   VL  + +L+E  KK        +S   LA +AK +T  L + +  +P   ++
Sbjct: 1150 IVLDTASDVLDKASSLIEEAKKAAGHPGDPESQQRLAQVAKAVTQALNRCVSCLPGQRDV 1209

Query: 503  DLAMENINETLNILNMGEFPPTDSSYGELQVXXXXXXXXXXXXXXXXXXXX-DDPRTLAD 561
            D A+  + +    L     PP+  ++ E Q                        P+ LA 
Sbjct: 1210 DNALRAVGDASKRLLSDSLPPSTGTFQEAQSRLNEAAAGLNQAATELVQASRGTPQDLAR 1269

Query: 562  SSHSFGQAFNNLLGVGMEMAGQTEDRETQSLMVNSMKSVTVNSSKLLGTAKSVSQDLSRP 621
            +S  FGQ F+  L  G+EMAGQ   +E ++ +V+++K ++++SSKLL  AK++S D + P
Sbjct: 1270 ASGRFGQDFSTFLEAGVEMAGQAPSQEDRAQVVSNLKGISMSSSKLLLAAKALSTDPAAP 1329

Query: 622  NAKNQLTAAARAVTDSINKLVDACTQAAPGHKACGAARRSVQAARPLLDAPAQPLSDLSY 681
            N K+QL AAARAVTDSIN+L+  CTQ APG K C  A R ++  R LL+ P QP++D+SY
Sbjct: 1330 NLKSQLAAAARAVTDSINQLITMCTQQAPGQKECDNALRELETVRELLENPVQPINDMSY 1389

Query: 682  FACLDAVLDHSKQLSE 697
            F CLD+V+++SK L E
Sbjct: 1390 FGCLDSVMENSKVLGE 1405



 Score = 39.9 bits (89), Expect = 0.030
 Identities = 24/86 (27%), Positives = 44/86 (51%)

Query: 585  EDRETQSLMVNSMKSVTVNSSKLLGTAKSVSQDLSRPNAKNQLTAAARAVTDSINKLVDA 644
            E R     +V S K++  ++  L+ TA++++ +   P + + L   +R V+DSI KL+ +
Sbjct: 1591 EGRAAMEPIVISAKTMLESAGGLIQTARALAVNPRDPPSWSVLAGHSRTVSDSIKKLITS 1650

Query: 645  CTQAAPGHKACGAARRSVQAARPLLD 670
                APG   C  A  ++ +    LD
Sbjct: 1651 MRDKAPGQLECETAIAALNSCLRDLD 1676



 Score = 34.3 bits (75), Expect = 1.5
 Identities = 34/115 (29%), Positives = 57/115 (49%), Gaps = 8/115 (6%)

Query: 555 DPR-TLADSSHSFGQAFNNLLGVGMEMAGQTE-DRETQSLMVNSMKSVTVNSSKLLGTAK 612
           +PR  L  ++ + GQA   LL    +  G+++ D   Q  ++   K+V   ++ L+  AK
Sbjct: 632 EPRQNLLQAAGNVGQASGELL----QQIGESDTDPHFQDALMQLAKAVASAAAALVLKAK 687

Query: 613 SVSQDLSRPNAKNQLTAAARAVTDSINKLVDACTQ-AAPGHKACGAARRSVQAAR 666
           SV+Q       + Q+ AAA     S ++LV ACT+  AP   +     + V+A R
Sbjct: 688 SVAQRTEDSGLQTQVIAAATQCALSTSQLV-ACTKVVAPTISSPVCQEQLVEAGR 741


>AF178534-1|AAF27330.1| 2540|Homo sapiens talin protein.
          Length = 2540

 Score =  260 bits (638), Expect = 9e-69
 Identities = 156/423 (36%), Positives = 234/423 (55%), Gaps = 8/423 (1%)

Query: 6    DILLSLAKAVANTTXXXXXXXXXXXXQCRDDQQLQNNIIAAATHCALATSQLVACAKVVA 65
            D L+ LAKAVA+              Q  +D  LQ  +IAAAT CAL+TSQLVAC KVVA
Sbjct: 666  DALMQLAKAVASAAAALVLKAKSVA-QRTEDSGLQTQVIAAATQCALSTSQLVACTKVVA 724

Query: 66   PTLHSAACREQLTSAARQVAQAVDRLVEXXXXXXXXXXXXXXXXXXXXHCVSEELERLLA 125
            PT+ S  C+EQL  A R VA+AV+  V                       V++ L  LL 
Sbjct: 725  PTISSPVCQEQLVEAGRLVAKAVEGCVSASQAATEDGQLLRGVGAAAT-AVTQALNELLQ 783

Query: 126  HCQXXXXXX--XXXXXXXXXXXXXXHERLLAAAGPA-DMLRHARQLGHATALLITNIKTE 182
            H +                       E + ++ G A +M+R AR L  AT+ L+  IK +
Sbjct: 784  HVKAHATGAGPAGRYDQATDTILTVTENIFSSMGDAGEMVRQARILAQATSDLVNAIKAD 843

Query: 183  AE-ESPSDSQRXXXXXXXXXXDATARMVEAARQCASSPQDREKQEVLRKAAEELRFITAD 241
            AE ES  ++ R          DATA+MVEAA+  A+ P   E+Q+ LR+AAE LR  T  
Sbjct: 844  AEGESDLENSRKLLSAAKILADATAKMVEAAKGAAAHPDSEEQQQRLREAAEGLRMATNA 903

Query: 242  YAQGQDIVGSQVARLQESARQATSSATQLITSAQNATQY-NTNRYSQETLLEECKVLNEH 300
             AQ   I    V RL+ +A+QA +SATQ I +AQ+A      +   Q  L++ CK + E 
Sbjct: 904  AAQNA-IKKKLVQRLEHAAKQAAASATQTIAAAQHAASTPKASAGPQPLLVQSCKAVAEQ 962

Query: 301  LPRMVEAVNVSNVKPTQAAARLDLISASEAFLQPSGHVISAARGALPTVSEPSAAKHLAD 360
            +P +V+ V  S  +P   +A+L LI+AS++FLQP G +++AA+ ++PT+ + ++A  L+ 
Sbjct: 963  IPLLVQGVRGSQAQPDSPSAQLALIAASQSFLQPGGKMVAAAKASVPTIQDQASAMQLSQ 1022

Query: 361  NTQLYTSSCADLRSAVSRARISCKGLELDAAAEIIKSLQEELDELEEAVRAFDLKPLPGQ 420
              +   ++ A+LR+A  +A+ +C  LE+D+A  ++++L+++L E++ A R   LKPLPG+
Sbjct: 1023 CAKNLGTALAELRTAAQKAQEACGPLEMDSALSVVQNLEKDLQEVKAAARDGKLKPLPGE 1082

Query: 421  TAE 423
            T E
Sbjct: 1083 TME 1085



 Score =  179 bits (436), Expect = 3e-44
 Identities = 94/256 (36%), Positives = 145/256 (56%), Gaps = 2/256 (0%)

Query: 444  VVISSGRQVLYSSLTLVETVKKQISSSEQVDSAA-LASIAKDITHGLEQTMEAVPSHTEL 502
            +V+ +   VL  + +L+E  KK        +S   LA +AK +T  L + +  +P   ++
Sbjct: 1150 IVLDTASDVLDKASSLIEEAKKAAGHPGDPESQQRLAQVAKAVTQALNRCVSCLPGQRDV 1209

Query: 503  DLAMENINETLNILNMGEFPPTDSSYGELQVXXXXXXXXXXXXXXXXXXXX-DDPRTLAD 561
            D A+  + +    L     PP+  ++ E Q                        P+ LA 
Sbjct: 1210 DNALRAVGDASKRLLSDSLPPSTGTFQEAQSRLNEAAAGLNQAATELVQASRGTPQDLAR 1269

Query: 562  SSHSFGQAFNNLLGVGMEMAGQTEDRETQSLMVNSMKSVTVNSSKLLGTAKSVSQDLSRP 621
            +S  FGQ F+  L  G+EMAGQ   +E ++ +V+++K ++++SSKLL  AK++S D + P
Sbjct: 1270 ASGRFGQDFSTFLEAGVEMAGQAPSQEDRAQVVSNLKGISMSSSKLLLAAKALSTDPAAP 1329

Query: 622  NAKNQLTAAARAVTDSINKLVDACTQAAPGHKACGAARRSVQAARPLLDAPAQPLSDLSY 681
            N K+QL AAARAVTDSIN+L+  CTQ APG K C  A R ++  R LL+ P QP++D+SY
Sbjct: 1330 NLKSQLAAAARAVTDSINQLITMCTQQAPGQKECDNALRELETVRELLENPVQPINDMSY 1389

Query: 682  FACLDAVLDHSKQLSE 697
            F CLD+V+++SK L E
Sbjct: 1390 FGCLDSVMENSKVLGE 1405



 Score = 39.9 bits (89), Expect = 0.030
 Identities = 24/86 (27%), Positives = 44/86 (51%)

Query: 585  EDRETQSLMVNSMKSVTVNSSKLLGTAKSVSQDLSRPNAKNQLTAAARAVTDSINKLVDA 644
            E R     +V S K++  ++  L+ TA++++ +   P + + L   +R V+DSI KL+ +
Sbjct: 1591 EGRAAMEPIVISAKTMLESAGGLIQTARALAVNPRDPPSWSVLAGHSRTVSDSIKKLITS 1650

Query: 645  CTQAAPGHKACGAARRSVQAARPLLD 670
                APG   C  A  ++ +    LD
Sbjct: 1651 MRDKAPGQLECETAIAALNSCLRDLD 1676



 Score = 34.3 bits (75), Expect = 1.5
 Identities = 34/115 (29%), Positives = 57/115 (49%), Gaps = 8/115 (6%)

Query: 555 DPR-TLADSSHSFGQAFNNLLGVGMEMAGQTE-DRETQSLMVNSMKSVTVNSSKLLGTAK 612
           +PR  L  ++ + GQA   LL    +  G+++ D   Q  ++   K+V   ++ L+  AK
Sbjct: 632 EPRQNLLQAAGNVGQASGELL----QQIGESDTDPHFQDALMQLAKAVASAAAALVLKAK 687

Query: 613 SVSQDLSRPNAKNQLTAAARAVTDSINKLVDACTQ-AAPGHKACGAARRSVQAAR 666
           SV+Q       + Q+ AAA     S ++LV ACT+  AP   +     + V+A R
Sbjct: 688 SVAQRTEDSGLQTQVIAAATQCALSTSQLV-ACTKVVAPTISSPVCQEQLVEAGR 741


>AB028950-1|BAA82979.2| 2550|Homo sapiens KIAA1027 protein protein.
          Length = 2550

 Score =  260 bits (638), Expect = 9e-69
 Identities = 156/423 (36%), Positives = 234/423 (55%), Gaps = 8/423 (1%)

Query: 6    DILLSLAKAVANTTXXXXXXXXXXXXQCRDDQQLQNNIIAAATHCALATSQLVACAKVVA 65
            D L+ LAKAVA+              Q  +D  LQ  +IAAAT CAL+TSQLVAC KVVA
Sbjct: 675  DALMQLAKAVASAAAALVLKAKSVA-QRTEDSGLQTQVIAAATQCALSTSQLVACTKVVA 733

Query: 66   PTLHSAACREQLTSAARQVAQAVDRLVEXXXXXXXXXXXXXXXXXXXXHCVSEELERLLA 125
            PT+ S  C+EQL  A R VA+AV+  V                       V++ L  LL 
Sbjct: 734  PTISSPVCQEQLVEAGRLVAKAVEGCVSASQAATEDGQLLRGVGAAAT-AVTQALNELLQ 792

Query: 126  HCQXXXXXX--XXXXXXXXXXXXXXHERLLAAAGPA-DMLRHARQLGHATALLITNIKTE 182
            H +                       E + ++ G A +M+R AR L  AT+ L+  IK +
Sbjct: 793  HVKAHATGAGPAGRYDQATDTILTVTENIFSSMGDAGEMVRQARILAQATSDLVNAIKAD 852

Query: 183  AE-ESPSDSQRXXXXXXXXXXDATARMVEAARQCASSPQDREKQEVLRKAAEELRFITAD 241
            AE ES  ++ R          DATA+MVEAA+  A+ P   E+Q+ LR+AAE LR  T  
Sbjct: 853  AEGESDLENSRKLLSAAKILADATAKMVEAAKGAAAHPDSEEQQQRLREAAEGLRMATNA 912

Query: 242  YAQGQDIVGSQVARLQESARQATSSATQLITSAQNATQY-NTNRYSQETLLEECKVLNEH 300
             AQ   I    V RL+ +A+QA +SATQ I +AQ+A      +   Q  L++ CK + E 
Sbjct: 913  AAQNA-IKKKLVQRLEHAAKQAAASATQTIAAAQHAASTPKASAGPQPLLVQSCKAVAEQ 971

Query: 301  LPRMVEAVNVSNVKPTQAAARLDLISASEAFLQPSGHVISAARGALPTVSEPSAAKHLAD 360
            +P +V+ V  S  +P   +A+L LI+AS++FLQP G +++AA+ ++PT+ + ++A  L+ 
Sbjct: 972  IPLLVQGVRGSQAQPDSPSAQLALIAASQSFLQPGGKMVAAAKASVPTIQDQASAMQLSQ 1031

Query: 361  NTQLYTSSCADLRSAVSRARISCKGLELDAAAEIIKSLQEELDELEEAVRAFDLKPLPGQ 420
              +   ++ A+LR+A  +A+ +C  LE+D+A  ++++L+++L E++ A R   LKPLPG+
Sbjct: 1032 CAKNLGTALAELRTAAQKAQEACGPLEMDSALSVVQNLEKDLQEVKAAARDGKLKPLPGE 1091

Query: 421  TAE 423
            T E
Sbjct: 1092 TME 1094



 Score =  179 bits (436), Expect = 3e-44
 Identities = 94/256 (36%), Positives = 145/256 (56%), Gaps = 2/256 (0%)

Query: 444  VVISSGRQVLYSSLTLVETVKKQISSSEQVDSAA-LASIAKDITHGLEQTMEAVPSHTEL 502
            +V+ +   VL  + +L+E  KK        +S   LA +AK +T  L + +  +P   ++
Sbjct: 1159 IVLDTASDVLDKASSLIEEAKKAAGHPGDPESQQRLAQVAKAVTQALNRCVSCLPGQRDV 1218

Query: 503  DLAMENINETLNILNMGEFPPTDSSYGELQVXXXXXXXXXXXXXXXXXXXX-DDPRTLAD 561
            D A+  + +    L     PP+  ++ E Q                        P+ LA 
Sbjct: 1219 DNALRAVGDASKRLLSDSLPPSTGTFQEAQSRLNEAAAGLNQAATELVQASRGTPQDLAR 1278

Query: 562  SSHSFGQAFNNLLGVGMEMAGQTEDRETQSLMVNSMKSVTVNSSKLLGTAKSVSQDLSRP 621
            +S  FGQ F+  L  G+EMAGQ   +E ++ +V+++K ++++SSKLL  AK++S D + P
Sbjct: 1279 ASGRFGQDFSTFLEAGVEMAGQAPSQEDRAQVVSNLKGISMSSSKLLLAAKALSTDPAAP 1338

Query: 622  NAKNQLTAAARAVTDSINKLVDACTQAAPGHKACGAARRSVQAARPLLDAPAQPLSDLSY 681
            N K+QL AAARAVTDSIN+L+  CTQ APG K C  A R ++  R LL+ P QP++D+SY
Sbjct: 1339 NLKSQLAAAARAVTDSINQLITMCTQQAPGQKECDNALRELETVRELLENPVQPINDMSY 1398

Query: 682  FACLDAVLDHSKQLSE 697
            F CLD+V+++SK L E
Sbjct: 1399 FGCLDSVMENSKVLGE 1414



 Score = 39.9 bits (89), Expect = 0.030
 Identities = 24/86 (27%), Positives = 44/86 (51%)

Query: 585  EDRETQSLMVNSMKSVTVNSSKLLGTAKSVSQDLSRPNAKNQLTAAARAVTDSINKLVDA 644
            E R     +V S K++  ++  L+ TA++++ +   P + + L   +R V+DSI KL+ +
Sbjct: 1600 EGRAAMEPIVISAKTMLESAGGLIQTARALAVNPRDPPSWSVLAGHSRTVSDSIKKLITS 1659

Query: 645  CTQAAPGHKACGAARRSVQAARPLLD 670
                APG   C  A  ++ +    LD
Sbjct: 1660 MRDKAPGQLECETAIAALNSCLRDLD 1685



 Score = 34.3 bits (75), Expect = 1.5
 Identities = 34/115 (29%), Positives = 57/115 (49%), Gaps = 8/115 (6%)

Query: 555 DPR-TLADSSHSFGQAFNNLLGVGMEMAGQTE-DRETQSLMVNSMKSVTVNSSKLLGTAK 612
           +PR  L  ++ + GQA   LL    +  G+++ D   Q  ++   K+V   ++ L+  AK
Sbjct: 641 EPRQNLLQAAGNVGQASGELL----QQIGESDTDPHFQDALMQLAKAVASAAAALVLKAK 696

Query: 613 SVSQDLSRPNAKNQLTAAARAVTDSINKLVDACTQ-AAPGHKACGAARRSVQAAR 666
           SV+Q       + Q+ AAA     S ++LV ACT+  AP   +     + V+A R
Sbjct: 697 SVAQRTEDSGLQTQVIAAATQCALSTSQLV-ACTKVVAPTISSPVCQEQLVEAGR 750


>AF402000-1|AAM73764.1| 2542|Homo sapiens talin 2 protein.
          Length = 2542

 Score =  258 bits (631), Expect = 6e-68
 Identities = 153/422 (36%), Positives = 237/422 (56%), Gaps = 7/422 (1%)

Query: 6    DILLSLAKAVANTTXXXXXXXXXXXXQCRDDQQLQNNIIAAATHCALATSQLVACAKVVA 65
            D+L+SLAKAVAN              Q  +D  LQN +IAAAT CAL+TSQLVACAKVV+
Sbjct: 669  DVLMSLAKAVANAAAMLVLKAKNVA-QVAEDTVLQNRVIAAATQCALSTSQLVACAKVVS 727

Query: 66   PTLHSAACREQLTSAARQVAQAVDRLVEXXXXXXXXXXXXXXXXXXXXHCVSEELERLLA 125
            PT+ S  C+EQL  A + V ++V+  V                       VS+ L  LL 
Sbjct: 728  PTISSPVCQEQLIEAGKLVDRSVENCVRACQAATTDSELLKQVSAAAS-VVSQALHDLLQ 786

Query: 126  HCQXXXXXXXXXXXXXXXXXXXX--HERLLAAAGPA-DMLRHARQLGHATALLITNIKTE 182
            H +                       E + ++ G A +M+R AR L  AT+ L+  ++++
Sbjct: 787  HVRQFASRGEPIGRYDQATDTIMCVTESIFSSMGDAGEMVRQARVLAQATSDLVNAMRSD 846

Query: 183  AE-ESPSDSQRXXXXXXXXXXDATARMVEAARQCASSPQDREKQEVLRKAAEELRFITAD 241
            AE E   ++ +          D+TARMVEAA+  A++P++ ++Q+ LR+AAE LR  T  
Sbjct: 847  AEAEIDMENSKKLLAAAKLLADSTARMVEAAKGAAANPENEDQQQRLREAAEGLRVATNA 906

Query: 242  YAQGQDIVGSQVARLQESARQATSSATQLITSAQNATQYNTNRYSQETLLEECKVLNEHL 301
             AQ   I    V RL+ +A+QA ++ATQ I ++QNA   N N  +Q+ L++ CK + +H+
Sbjct: 907  AAQNA-IKKKIVNRLEVAAKQAAAAATQTIAASQNAAVSNKNPAAQQQLVQSCKAVADHI 965

Query: 302  PRMVEAVNVSNVKPTQAAARLDLISASEAFLQPSGHVISAARGALPTVSEPSAAKHLADN 361
            P++V+ V  S  +    +A+L LI +S+ FLQP   ++S+A+ A+PTVS+ +AA  L+  
Sbjct: 966  PQLVQGVRGSQAQAEDLSAQLALIISSQNFLQPGSKMVSSAKAAVPTVSDQAAAMQLSQC 1025

Query: 362  TQLYTSSCADLRSAVSRARISCKGLELDAAAEIIKSLQEELDELEEAVRAFDLKPLPGQT 421
             +   +S A+LR+A  +A  +C  +E+D+A   +++L+ EL + + A     LKPLPG+T
Sbjct: 1026 AKNLATSLAELRTASQKAHEACGPMEIDSALNTVQTLKNELQDAKMAAVESQLKPLPGET 1085

Query: 422  AE 423
             E
Sbjct: 1086 LE 1087



 Score =  171 bits (416), Expect = 7e-42
 Identities = 90/255 (35%), Positives = 142/255 (55%), Gaps = 2/255 (0%)

Query: 445  VISSGRQVLYSSLTLVETVKKQ-ISSSEQVDSAALASIAKDITHGLEQTMEAVPSHTELD 503
            ++ S R V+  S  L++  K+  I+  +      LA +AK ++H L   +  +P   ++D
Sbjct: 1153 MLDSARDVMEGSAMLIQEAKQALIAPGDAERQQRLAQVAKAVSHSLNNCVNCLPGQKDVD 1212

Query: 504  LAMENINETLNILNMGEFPPTDSSYGELQVXXXXXXXXXXXXXXXXXXXX-DDPRTLADS 562
            +A+++I E+   L +   PP+   + E Q                            A +
Sbjct: 1213 VALKSIGESSKKLLVDSLPPSTKPFQEAQSELNQAAADLNQSAGEVVHATRGQSGEFAAA 1272

Query: 563  SHSFGQAFNNLLGVGMEMAGQTEDRETQSLMVNSMKSVTVNSSKLLGTAKSVSQDLSRPN 622
            S  F   F+  L  G+EMAGQ + +E Q  ++ ++K++++ SSKLL  AKS+S D   PN
Sbjct: 1273 SGKFSDDFDEFLDAGIEMAGQAQTKEDQIQVIGNLKNISMASSKLLLAAKSLSVDPGAPN 1332

Query: 623  AKNQLTAAARAVTDSINKLVDACTQAAPGHKACGAARRSVQAARPLLDAPAQPLSDLSYF 682
            AKN L AAARAVT+SIN+L+  CTQ APG K C  A R ++  + +LD P +P+SDLSYF
Sbjct: 1333 AKNLLAAAARAVTESINQLITLCTQQAPGQKECDNALRELETVKGMLDNPNEPVSDLSYF 1392

Query: 683  ACLDAVLDHSKQLSE 697
             C+++V+++SK L E
Sbjct: 1393 DCIESVMENSKVLGE 1407



 Score = 40.7 bits (91), Expect = 0.017
 Identities = 72/393 (18%), Positives = 148/393 (37%), Gaps = 25/393 (6%)

Query: 282  TNRYSQETLLEECK-VLNEHLPRMVEAVNVSNVKPTQAAARLDLISASEAFLQPSGHVIS 340
            T+   Q+ L+   K V N     +++A NV+ V          + +A++  L  S  +++
Sbjct: 663  TDERFQDVLMSLAKAVANAAAMLVLKAKNVAQVAEDTVLQNRVIAAATQCALSTS-QLVA 721

Query: 341  AARGALPTVSEPSAAKHLADNTQLYTSSCADLRSAVSRARISCKGL-ELDAAAEIIKSLQ 399
             A+   PT+S P   + L +  +L   S  +   A   A    + L ++ AAA ++    
Sbjct: 722  CAKVVSPTISSPVCQEQLIEAGKLVDRSVENCVRACQAATTDSELLKQVSAAASVVS--- 778

Query: 400  EELDELEEAVRAFDLKPLP-GQTAEWXXXXXXXXXXXXXXXXXXLVVISSGRQVLYSSLT 458
            + L +L + VR F  +  P G+  +                     ++   R +  ++  
Sbjct: 779  QALHDLLQHVRQFASRGEPIGRYDQATDTIMCVTESIFSSMGDAGEMVRQARVLAQATSD 838

Query: 459  LVETVKKQISSSEQVDSA----ALASIAKDITHGLEQTMEAVPSHTELDLAMENINETLN 514
            LV  ++    +   ++++    A A +  D T  + +  +   ++ E +   + + E   
Sbjct: 839  LVNAMRSDAEAEIDMENSKKLLAAAKLLADSTARMVEAAKGAAANPENEDQQQRLREAAE 898

Query: 515  ILNMGEFPPTDSSY-----GELQVXXXXXXXXXXXXXXXXXXXX---DDP---RTLADSS 563
             L +       ++        L+V                        +P   + L  S 
Sbjct: 899  GLRVATNAAAQNAIKKKIVNRLEVAAKQAAAAATQTIAASQNAAVSNKNPAAQQQLVQSC 958

Query: 564  HSFGQAFNNLLGVGMEMAGQTEDRETQSLMVNSMKSVTVNSSKLLGTAKSVSQDLSRPNA 623
             +       L+        Q ED   Q  ++ S ++     SK++ +AK+    +S   A
Sbjct: 959  KAVADHIPQLVQGVRGSQAQAEDLSAQLALIISSQNFLQPGSKMVSSAKAAVPTVSDQAA 1018

Query: 624  KNQLTAAARAVTDSINKLVDACTQAAPGHKACG 656
              QL+  A+ +  S+ +L  A  +A   H+ACG
Sbjct: 1019 AMQLSQCAKNLATSLAELRTASQKA---HEACG 1048



 Score = 39.9 bits (89), Expect = 0.030
 Identities = 21/72 (29%), Positives = 39/72 (54%)

Query: 584  TEDRETQSLMVNSMKSVTVNSSKLLGTAKSVSQDLSRPNAKNQLTAAARAVTDSINKLVD 643
            +E  + Q  ++ S K++  +SS L+ TA+S++ +   P   + L   +  V+DSI  L+ 
Sbjct: 1592 SEGSQAQEPILVSAKTMLESSSYLIRTARSLAINPKDPPTWSVLAGHSHTVSDSIKSLIT 1651

Query: 644  ACTQAAPGHKAC 655
            +    APG + C
Sbjct: 1652 SIRDKAPGQREC 1663



 Score = 33.9 bits (74), Expect = 2.0
 Identities = 28/92 (30%), Positives = 40/92 (43%), Gaps = 4/92 (4%)

Query: 1    MAALTDILLSLAKAVANTTXXXXXXXXXXXXQCRDDQQLQNNIIAAATHCALATSQLVAC 60
            +AA T  L+  A A A                  DD Q    +I+AA   A ATS L   
Sbjct: 2353 IAAATSALVKSASA-AQRELVAQGKVGSIPANAADDGQWSQGLISAARMVAAATSSLCEA 2411

Query: 61   AKVVAPTLHSAACREQLTSAARQVAQAVDRLV 92
            A     ++   A  E+L S+A+QVA +  +L+
Sbjct: 2412 ANA---SVQGHASEEKLISSAKQVAASTAQLL 2440


>AF177198-1|AAF23322.1| 2541|Homo sapiens talin protein.
          Length = 2541

 Score =  258 bits (631), Expect = 6e-68
 Identities = 155/423 (36%), Positives = 233/423 (55%), Gaps = 8/423 (1%)

Query: 6    DILLSLAKAVANTTXXXXXXXXXXXXQCRDDQQLQNNIIAAATHCALATSQLVACAKVVA 65
            D L+ LAKAVA+              Q  +D  LQ  +IAAAT CAL+TSQLVAC KVVA
Sbjct: 666  DALMQLAKAVASAAAALVLKAKSVA-QRTEDSGLQTQVIAAATQCALSTSQLVACTKVVA 724

Query: 66   PTLHSAACREQLTSAARQVAQAVDRLVEXXXXXXXXXXXXXXXXXXXXHCVSEELERLLA 125
            PT+ S  C+EQL  A R VA+AV+  V                       V++ L  LL 
Sbjct: 725  PTISSPVCQEQLVEAGRLVAKAVEGCVSASQAATEDGQLLRGVGAAAT-AVTQALNELLQ 783

Query: 126  HCQXXXXXX--XXXXXXXXXXXXXXHERLLAAAGPA-DMLRHARQLGHATALLITNIKTE 182
            H +                       E + ++ G A +M+  AR L  AT+ L+  IK +
Sbjct: 784  HVKAHATGAGPAGRYDQATDTILTVTENIFSSMGDAGEMVGQARILAQATSDLVNAIKAD 843

Query: 183  AE-ESPSDSQRXXXXXXXXXXDATARMVEAARQCASSPQDREKQEVLRKAAEELRFITAD 241
            AE ES  ++ R          DATA+MVEAA+  A+ P   E+Q+ LR+AAE LR  T  
Sbjct: 844  AEGESDLENSRKLLSAAKILADATAKMVEAAKGAAAHPDSEEQQQRLREAAEGLRMATNA 903

Query: 242  YAQGQDIVGSQVARLQESARQATSSATQLITSAQNATQY-NTNRYSQETLLEECKVLNEH 300
             AQ   I    V RL+ +A+QA +SATQ I +AQ+A      +   Q  L++ CK + E 
Sbjct: 904  AAQNA-IKKKLVQRLEHAAKQAAASATQTIAAAQHAASTPKASAGPQPLLVQSCKAVAEQ 962

Query: 301  LPRMVEAVNVSNVKPTQAAARLDLISASEAFLQPSGHVISAARGALPTVSEPSAAKHLAD 360
            +P +V+ V  S  +P   +A+L LI+AS++FLQP G +++AA+ ++PT+ + ++A  L+ 
Sbjct: 963  IPLLVQGVRGSQAQPDSPSAQLALIAASQSFLQPGGKMVAAAKASVPTIQDQASAMQLSQ 1022

Query: 361  NTQLYTSSCADLRSAVSRARISCKGLELDAAAEIIKSLQEELDELEEAVRAFDLKPLPGQ 420
              +   ++ A+LR+A  +A+ +C  LE+D+A  ++++L+++L E++ A R   LKPLPG+
Sbjct: 1023 CAKNLGTALAELRTAAQKAQEACGPLEMDSALSVVQNLEKDLQEVKAAARDGKLKPLPGE 1082

Query: 421  TAE 423
            T E
Sbjct: 1083 TME 1085



 Score =  179 bits (436), Expect = 3e-44
 Identities = 94/256 (36%), Positives = 145/256 (56%), Gaps = 2/256 (0%)

Query: 444  VVISSGRQVLYSSLTLVETVKKQISSSEQVDSAA-LASIAKDITHGLEQTMEAVPSHTEL 502
            +V+ +   VL  + +L+E  KK        +S   LA +AK +T  L + +  +P   ++
Sbjct: 1150 IVLDTASDVLDKASSLIEEAKKAAGHPGDPESQQRLAQVAKAVTQALNRCVSCLPGQRDV 1209

Query: 503  DLAMENINETLNILNMGEFPPTDSSYGELQVXXXXXXXXXXXXXXXXXXXX-DDPRTLAD 561
            D A+  + +    L     PP+  ++ E Q                        P+ LA 
Sbjct: 1210 DNALRAVGDASKRLLSDSLPPSTGTFQEAQSRLNEAAAGLNQAATELVQASRGTPQDLAR 1269

Query: 562  SSHSFGQAFNNLLGVGMEMAGQTEDRETQSLMVNSMKSVTVNSSKLLGTAKSVSQDLSRP 621
            +S  FGQ F+  L  G+EMAGQ   +E ++ +V+++K ++++SSKLL  AK++S D + P
Sbjct: 1270 ASGRFGQDFSTFLEAGVEMAGQAPSQEDRAQVVSNLKGISMSSSKLLLAAKALSTDPAAP 1329

Query: 622  NAKNQLTAAARAVTDSINKLVDACTQAAPGHKACGAARRSVQAARPLLDAPAQPLSDLSY 681
            N K+QL AAARAVTDSIN+L+  CTQ APG K C  A R ++  R LL+ P QP++D+SY
Sbjct: 1330 NLKSQLAAAARAVTDSINQLITMCTQQAPGQKECDNALRELETVRELLENPVQPINDMSY 1389

Query: 682  FACLDAVLDHSKQLSE 697
            F CLD+V+++SK L E
Sbjct: 1390 FGCLDSVMENSKVLGE 1405



 Score = 38.3 bits (85), Expect = 0.091
 Identities = 23/86 (26%), Positives = 44/86 (51%)

Query: 585  EDRETQSLMVNSMKSVTVNSSKLLGTAKSVSQDLSRPNAKNQLTAAARAVTDSINKLVDA 644
            E R     +V S +++  ++  L+ TA++++ +   P + + L   +R V+DSI KL+ +
Sbjct: 1591 EGRAAMEPIVISAQTMLESAGGLIQTARALAVNPRDPPSWSVLAGHSRTVSDSIKKLITS 1650

Query: 645  CTQAAPGHKACGAARRSVQAARPLLD 670
                APG   C  A  ++ +    LD
Sbjct: 1651 MRDKAPGQLECETAIAALNSCLRDLD 1676



 Score = 34.3 bits (75), Expect = 1.5
 Identities = 34/115 (29%), Positives = 57/115 (49%), Gaps = 8/115 (6%)

Query: 555 DPR-TLADSSHSFGQAFNNLLGVGMEMAGQTE-DRETQSLMVNSMKSVTVNSSKLLGTAK 612
           +PR  L  ++ + GQA   LL    +  G+++ D   Q  ++   K+V   ++ L+  AK
Sbjct: 632 EPRQNLLQAAGNVGQASGELL----QQIGESDTDPHFQDALMQLAKAVASAAAALVLKAK 687

Query: 613 SVSQDLSRPNAKNQLTAAARAVTDSINKLVDACTQ-AAPGHKACGAARRSVQAAR 666
           SV+Q       + Q+ AAA     S ++LV ACT+  AP   +     + V+A R
Sbjct: 688 SVAQRTEDSGLQTQVIAAATQCALSTSQLV-ACTKVVAPTISSPVCQEQLVEAGR 741


>AF078828-1|AAD13152.1| 2541|Homo sapiens talin protein.
          Length = 2541

 Score =  258 bits (631), Expect = 6e-68
 Identities = 155/423 (36%), Positives = 233/423 (55%), Gaps = 8/423 (1%)

Query: 6    DILLSLAKAVANTTXXXXXXXXXXXXQCRDDQQLQNNIIAAATHCALATSQLVACAKVVA 65
            D L+ LAKAVA+              Q  +D  LQ  +IAAAT CAL+TSQLVAC KVVA
Sbjct: 666  DALMQLAKAVASAAAALVLKAKSVA-QRTEDSGLQTQVIAAATQCALSTSQLVACTKVVA 724

Query: 66   PTLHSAACREQLTSAARQVAQAVDRLVEXXXXXXXXXXXXXXXXXXXXHCVSEELERLLA 125
            PT+ S  C+EQL  A R VA+AV+  V                       V++ L  LL 
Sbjct: 725  PTISSPVCQEQLVEAGRLVAKAVEGCVSASQAATEDGQLLRGVGAAAT-AVTQALNELLQ 783

Query: 126  HCQXXXXXX--XXXXXXXXXXXXXXHERLLAAAGPA-DMLRHARQLGHATALLITNIKTE 182
            H +                       E + ++ G A +M+  AR L  AT+ L+  IK +
Sbjct: 784  HVKAHATGAGPAGRYDQATDTILTVTENIFSSMGDAGEMVGQARILAQATSDLVNAIKAD 843

Query: 183  AE-ESPSDSQRXXXXXXXXXXDATARMVEAARQCASSPQDREKQEVLRKAAEELRFITAD 241
            AE ES  ++ R          DATA+MVEAA+  A+ P   E+Q+ LR+AAE LR  T  
Sbjct: 844  AEGESDLENSRKLLSAAKILADATAKMVEAAKGAAAHPDSEEQQQRLREAAEGLRMATNA 903

Query: 242  YAQGQDIVGSQVARLQESARQATSSATQLITSAQNATQY-NTNRYSQETLLEECKVLNEH 300
             AQ   I    V RL+ +A+QA +SATQ I +AQ+A      +   Q  L++ CK + E 
Sbjct: 904  AAQNA-IKKKLVQRLEHAAKQAAASATQTIAAAQHAASTPKASAGPQPLLVQSCKAVAEQ 962

Query: 301  LPRMVEAVNVSNVKPTQAAARLDLISASEAFLQPSGHVISAARGALPTVSEPSAAKHLAD 360
            +P +V+ V  S  +P   +A+L LI+AS++FLQP G +++AA+ ++PT+ + ++A  L+ 
Sbjct: 963  IPLLVQGVRGSQAQPDSPSAQLALIAASQSFLQPGGKMVAAAKASVPTIQDQASAMQLSQ 1022

Query: 361  NTQLYTSSCADLRSAVSRARISCKGLELDAAAEIIKSLQEELDELEEAVRAFDLKPLPGQ 420
              +   ++ A+LR+A  +A+ +C  LE+D+A  ++++L+++L E++ A R   LKPLPG+
Sbjct: 1023 CAKNLGTALAELRTAAQKAQEACGPLEMDSALSVVQNLEKDLQEVKAAARDGKLKPLPGE 1082

Query: 421  TAE 423
            T E
Sbjct: 1083 TME 1085



 Score =  178 bits (433), Expect = 6e-44
 Identities = 94/256 (36%), Positives = 145/256 (56%), Gaps = 2/256 (0%)

Query: 444  VVISSGRQVLYSSLTLVETVKKQISSSEQVDSAA-LASIAKDITHGLEQTMEAVPSHTEL 502
            +V+ +   VL  + +L+E  KK        +S   LA +AK +T  L + +  +P   ++
Sbjct: 1150 IVLDTASDVLDKASSLIEEAKKAAGHPGDPESQQRLAQVAKAVTQALNRCVSCLPGQRDV 1209

Query: 503  DLAMENINETLNILNMGEFPPTDSSYGELQVXXXXXXXXXXXXXXXXXXXX-DDPRTLAD 561
            D A+  + +    L     PP+  ++ E Q                        P+ LA 
Sbjct: 1210 DNALRAVGDASKRLLSDLLPPSTGTFQEAQSRLNEAAAGLNQAATELVQASRGTPQDLAR 1269

Query: 562  SSHSFGQAFNNLLGVGMEMAGQTEDRETQSLMVNSMKSVTVNSSKLLGTAKSVSQDLSRP 621
            +S  FGQ F+  L  G+EMAGQ   +E ++ +V+++K ++++SSKLL  AK++S D + P
Sbjct: 1270 ASGRFGQDFSTFLEAGVEMAGQAPSQEDRAQVVSNLKGISMSSSKLLLAAKALSTDPAAP 1329

Query: 622  NAKNQLTAAARAVTDSINKLVDACTQAAPGHKACGAARRSVQAARPLLDAPAQPLSDLSY 681
            N K+QL AAARAVTDSIN+L+  CTQ APG K C  A R ++  R LL+ P QP++D+SY
Sbjct: 1330 NLKSQLAAAARAVTDSINQLITMCTQQAPGQKECDNALRELETVRELLENPVQPINDMSY 1389

Query: 682  FACLDAVLDHSKQLSE 697
            F CLD+V+++SK L E
Sbjct: 1390 FGCLDSVMENSKVLGE 1405



 Score = 38.3 bits (85), Expect = 0.091
 Identities = 23/86 (26%), Positives = 44/86 (51%)

Query: 585  EDRETQSLMVNSMKSVTVNSSKLLGTAKSVSQDLSRPNAKNQLTAAARAVTDSINKLVDA 644
            E R     +V S +++  ++  L+ TA++++ +   P + + L   +R V+DSI KL+ +
Sbjct: 1591 EGRAAMEPIVISAQTMLESAGGLIQTARALAVNPRDPPSWSVLAGHSRTVSDSIKKLITS 1650

Query: 645  CTQAAPGHKACGAARRSVQAARPLLD 670
                APG   C  A  ++ +    LD
Sbjct: 1651 MRDKAPGQLECETAIAALNSCLRDLD 1676



 Score = 34.3 bits (75), Expect = 1.5
 Identities = 34/115 (29%), Positives = 57/115 (49%), Gaps = 8/115 (6%)

Query: 555 DPR-TLADSSHSFGQAFNNLLGVGMEMAGQTE-DRETQSLMVNSMKSVTVNSSKLLGTAK 612
           +PR  L  ++ + GQA   LL    +  G+++ D   Q  ++   K+V   ++ L+  AK
Sbjct: 632 EPRQNLLQAAGNVGQASGELL----QQIGESDTDPHFQDALMQLAKAVASAAAALVLKAK 687

Query: 613 SVSQDLSRPNAKNQLTAAARAVTDSINKLVDACTQ-AAPGHKACGAARRSVQAAR 666
           SV+Q       + Q+ AAA     S ++LV ACT+  AP   +     + V+A R
Sbjct: 688 SVAQRTEDSGLQTQVIAAATQCALSTSQLV-ACTKVVAPTISSPVCQEQLVEAGR 741


>AB002318-1|BAA20778.2| 1933|Homo sapiens KIAA0320 protein.
          Length = 1933

 Score =  258 bits (631), Expect = 6e-68
 Identities = 153/422 (36%), Positives = 237/422 (56%), Gaps = 7/422 (1%)

Query: 6   DILLSLAKAVANTTXXXXXXXXXXXXQCRDDQQLQNNIIAAATHCALATSQLVACAKVVA 65
           D+L+SLAKAVAN              Q  +D  LQN +IAAAT CAL+TSQLVACAKVV+
Sbjct: 60  DVLMSLAKAVANAAAMLVLKAKNVA-QVAEDTVLQNRVIAAATQCALSTSQLVACAKVVS 118

Query: 66  PTLHSAACREQLTSAARQVAQAVDRLVEXXXXXXXXXXXXXXXXXXXXHCVSEELERLLA 125
           PT+ S  C+EQL  A + V ++V+  V                       VS+ L  LL 
Sbjct: 119 PTISSPVCQEQLIEAGKLVDRSVENCVRACQAATTDSELLKQVSAAAS-VVSQALHDLLQ 177

Query: 126 HCQXXXXXXXXXXXXXXXXXXXX--HERLLAAAGPA-DMLRHARQLGHATALLITNIKTE 182
           H +                       E + ++ G A +M+R AR L  AT+ L+  ++++
Sbjct: 178 HVRQFASRGEPIGRYDQATDTIMCVTESIFSSMGDAGEMVRQARVLAQATSDLVNAMRSD 237

Query: 183 AE-ESPSDSQRXXXXXXXXXXDATARMVEAARQCASSPQDREKQEVLRKAAEELRFITAD 241
           AE E   ++ +          D+TARMVEAA+  A++P++ ++Q+ LR+AAE LR  T  
Sbjct: 238 AEAEIDMENSKKLLAAAKLLADSTARMVEAAKGAAANPENEDQQQRLREAAEGLRVATNA 297

Query: 242 YAQGQDIVGSQVARLQESARQATSSATQLITSAQNATQYNTNRYSQETLLEECKVLNEHL 301
            AQ   I    V RL+ +A+QA ++ATQ I ++QNA   N N  +Q+ L++ CK + +H+
Sbjct: 298 AAQNA-IKKKIVNRLEVAAKQAAAAATQTIAASQNAAVSNKNPAAQQQLVQSCKAVADHI 356

Query: 302 PRMVEAVNVSNVKPTQAAARLDLISASEAFLQPSGHVISAARGALPTVSEPSAAKHLADN 361
           P++V+ V  S  +    +A+L LI +S+ FLQP   ++S+A+ A+PTVS+ +AA  L+  
Sbjct: 357 PQLVQGVRGSQAQAEDLSAQLALIISSQNFLQPGSKMVSSAKAAVPTVSDQAAAMQLSQC 416

Query: 362 TQLYTSSCADLRSAVSRARISCKGLELDAAAEIIKSLQEELDELEEAVRAFDLKPLPGQT 421
            +   +S A+LR+A  +A  +C  +E+D+A   +++L+ EL + + A     LKPLPG+T
Sbjct: 417 AKNLATSLAELRTASQKAHEACGPMEIDSALNTVQTLKNELQDAKMAAVESQLKPLPGET 476

Query: 422 AE 423
            E
Sbjct: 477 LE 478



 Score =  173 bits (420), Expect = 2e-42
 Identities = 91/255 (35%), Positives = 143/255 (56%), Gaps = 2/255 (0%)

Query: 445 VISSGRQVLYSSLTLVETVKKQ-ISSSEQVDSAALASIAKDITHGLEQTMEAVPSHTELD 503
           ++ S R V+  S  L++  K+  I+  +      LA +AK ++H L   +  +P   ++D
Sbjct: 544 MLDSARDVMEGSAMLIQEAKQALIAPGDAERQQRLAQVAKAVSHSLNNCVNCLPGQKDVD 603

Query: 504 LAMENINETLNILNMGEFPPTDSSYGELQVXXXXXXXXXXXXXXXXXXXX-DDPRTLADS 562
           +A+++I E+   L +   PP+   + E Q                           LA +
Sbjct: 604 VALKSIGESSKKLLVDSLPPSTKPFQEAQSELNQAAADLNQSAGEVVHATRGQSGELAAA 663

Query: 563 SHSFGQAFNNLLGVGMEMAGQTEDRETQSLMVNSMKSVTVNSSKLLGTAKSVSQDLSRPN 622
           S  F   F+  L  G+EMAGQ + +E Q  ++ ++K++++ SSKLL  AKS+S D   PN
Sbjct: 664 SGKFSDDFDEFLDAGIEMAGQAQTKEDQIQVIGNLKNISMASSKLLLAAKSLSVDPGAPN 723

Query: 623 AKNQLTAAARAVTDSINKLVDACTQAAPGHKACGAARRSVQAARPLLDAPAQPLSDLSYF 682
           AKN L AAARAVT+SIN+L+  CTQ APG K C  A R ++  + +LD P +P+SDLSYF
Sbjct: 724 AKNLLAAAARAVTESINQLITLCTQQAPGQKECDNALRELETVKGMLDNPNEPVSDLSYF 783

Query: 683 ACLDAVLDHSKQLSE 697
            C+++V+++SK L E
Sbjct: 784 DCIESVMENSKVLGE 798



 Score = 40.7 bits (91), Expect = 0.017
 Identities = 72/393 (18%), Positives = 148/393 (37%), Gaps = 25/393 (6%)

Query: 282 TNRYSQETLLEECK-VLNEHLPRMVEAVNVSNVKPTQAAARLDLISASEAFLQPSGHVIS 340
           T+   Q+ L+   K V N     +++A NV+ V          + +A++  L  S  +++
Sbjct: 54  TDERFQDVLMSLAKAVANAAAMLVLKAKNVAQVAEDTVLQNRVIAAATQCALSTS-QLVA 112

Query: 341 AARGALPTVSEPSAAKHLADNTQLYTSSCADLRSAVSRARISCKGL-ELDAAAEIIKSLQ 399
            A+   PT+S P   + L +  +L   S  +   A   A    + L ++ AAA ++    
Sbjct: 113 CAKVVSPTISSPVCQEQLIEAGKLVDRSVENCVRACQAATTDSELLKQVSAAASVVS--- 169

Query: 400 EELDELEEAVRAFDLKPLP-GQTAEWXXXXXXXXXXXXXXXXXXLVVISSGRQVLYSSLT 458
           + L +L + VR F  +  P G+  +                     ++   R +  ++  
Sbjct: 170 QALHDLLQHVRQFASRGEPIGRYDQATDTIMCVTESIFSSMGDAGEMVRQARVLAQATSD 229

Query: 459 LVETVKKQISSSEQVDSA----ALASIAKDITHGLEQTMEAVPSHTELDLAMENINETLN 514
           LV  ++    +   ++++    A A +  D T  + +  +   ++ E +   + + E   
Sbjct: 230 LVNAMRSDAEAEIDMENSKKLLAAAKLLADSTARMVEAAKGAAANPENEDQQQRLREAAE 289

Query: 515 ILNMGEFPPTDSSY-----GELQVXXXXXXXXXXXXXXXXXXXX---DDP---RTLADSS 563
            L +       ++        L+V                        +P   + L  S 
Sbjct: 290 GLRVATNAAAQNAIKKKIVNRLEVAAKQAAAAATQTIAASQNAAVSNKNPAAQQQLVQSC 349

Query: 564 HSFGQAFNNLLGVGMEMAGQTEDRETQSLMVNSMKSVTVNSSKLLGTAKSVSQDLSRPNA 623
            +       L+        Q ED   Q  ++ S ++     SK++ +AK+    +S   A
Sbjct: 350 KAVADHIPQLVQGVRGSQAQAEDLSAQLALIISSQNFLQPGSKMVSSAKAAVPTVSDQAA 409

Query: 624 KNQLTAAARAVTDSINKLVDACTQAAPGHKACG 656
             QL+  A+ +  S+ +L  A  +A   H+ACG
Sbjct: 410 AMQLSQCAKNLATSLAELRTASQKA---HEACG 439



 Score = 39.9 bits (89), Expect = 0.030
 Identities = 21/72 (29%), Positives = 39/72 (54%)

Query: 584  TEDRETQSLMVNSMKSVTVNSSKLLGTAKSVSQDLSRPNAKNQLTAAARAVTDSINKLVD 643
            +E  + Q  ++ S K++  +SS L+ TA+S++ +   P   + L   +  V+DSI  L+ 
Sbjct: 983  SEGSQAQEPILVSAKTMLESSSYLIRTARSLAINPKDPPTWSVLAGHSHTVSDSIKSLIT 1042

Query: 644  ACTQAAPGHKAC 655
            +    APG + C
Sbjct: 1043 SIRDKAPGQREC 1054



 Score = 33.9 bits (74), Expect = 2.0
 Identities = 28/92 (30%), Positives = 40/92 (43%), Gaps = 4/92 (4%)

Query: 1    MAALTDILLSLAKAVANTTXXXXXXXXXXXXQCRDDQQLQNNIIAAATHCALATSQLVAC 60
            +AA T  L+  A A A                  DD Q    +I+AA   A ATS L   
Sbjct: 1744 IAAATSALVKSASA-AQRELVAQGKVGSIPANAADDGQWSQGLISAARMVAAATSSLCEA 1802

Query: 61   AKVVAPTLHSAACREQLTSAARQVAQAVDRLV 92
            A     ++   A  E+L S+A+QVA +  +L+
Sbjct: 1803 ANA---SVQGHASEEKLISSAKQVAASTAQLL 1831


>BX538132-1|CAD98033.1|  965|Homo sapiens hypothetical protein
           protein.
          Length = 965

 Score = 33.5 bits (73), Expect = 2.6
 Identities = 23/67 (34%), Positives = 34/67 (50%), Gaps = 3/67 (4%)

Query: 340 SAARGALPTVSEPSAAKHLADNTQLYTSSCADLRSAVSRARISCKGLELDAAAEIIKSLQ 399
           S+ RG  P + EP       + +    +S   + SA ++   +C+ L+ DAA E  K L 
Sbjct: 733 SSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPE-TCERLDEDAAFE--KELT 789

Query: 400 EELDELE 406
           EEL ELE
Sbjct: 790 EELGELE 796


>BC125236-1|AAI25237.1|  473|Homo sapiens ANK2 protein protein.
          Length = 473

 Score = 33.5 bits (73), Expect = 2.6
 Identities = 23/67 (34%), Positives = 34/67 (50%), Gaps = 3/67 (4%)

Query: 340 SAARGALPTVSEPSAAKHLADNTQLYTSSCADLRSAVSRARISCKGLELDAAAEIIKSLQ 399
           S+ RG  P + EP       + +    +S   + SA ++   +C+ L+ DAA E  K L 
Sbjct: 302 SSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPE-TCERLDEDAAFE--KELT 358

Query: 400 EELDELE 406
           EEL ELE
Sbjct: 359 EELGELE 365


>BC125235-1|AAI25236.1|  555|Homo sapiens ANK2 protein protein.
          Length = 555

 Score = 33.5 bits (73), Expect = 2.6
 Identities = 23/67 (34%), Positives = 34/67 (50%), Gaps = 3/67 (4%)

Query: 340 SAARGALPTVSEPSAAKHLADNTQLYTSSCADLRSAVSRARISCKGLELDAAAEIIKSLQ 399
           S+ RG  P + EP       + +    +S   + SA ++   +C+ L+ DAA E  K L 
Sbjct: 384 SSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPE-TCERLDEDAAFE--KELT 440

Query: 400 EELDELE 406
           EEL ELE
Sbjct: 441 EELGELE 447


>AL121586-4|CAB89415.1| 2442|Homo sapiens centrosomal protein 250kDa
            protein.
          Length = 2442

 Score = 33.1 bits (72), Expect = 3.4
 Identities = 27/103 (26%), Positives = 53/103 (51%), Gaps = 5/103 (4%)

Query: 209  VEAARQCASSPQDREKQEVLRKAA--EELRFITADYAQGQDIVGSQVARLQE--SARQAT 264
            VE+ R+ A + Q++ + +V +  A  E L  +T   A+ ++ V +   ++QE    R+  
Sbjct: 1395 VESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQ 1454

Query: 265  SSATQLIT-SAQNATQYNTNRYSQETLLEECKVLNEHLPRMVE 306
             +A +L++   +   Q    +  Q   LE+C+ + EHLP  V+
Sbjct: 1455 KAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQ 1497


>AF049105-1|AAC07988.1| 2442|Homo sapiens centrosomal Nek2-associated
            protein 1 protein.
          Length = 2442

 Score = 33.1 bits (72), Expect = 3.4
 Identities = 27/103 (26%), Positives = 53/103 (51%), Gaps = 5/103 (4%)

Query: 209  VEAARQCASSPQDREKQEVLRKAA--EELRFITADYAQGQDIVGSQVARLQE--SARQAT 264
            VE+ R+ A + Q++ + +V +  A  E L  +T   A+ ++ V +   ++QE    R+  
Sbjct: 1395 VESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQ 1454

Query: 265  SSATQLIT-SAQNATQYNTNRYSQETLLEECKVLNEHLPRMVE 306
             +A +L++   +   Q    +  Q   LE+C+ + EHLP  V+
Sbjct: 1455 KAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQ 1497


>AF022655-1|AAC06349.1| 2442|Homo sapiens cep250 centrosome associated
            protein protein.
          Length = 2442

 Score = 33.1 bits (72), Expect = 3.4
 Identities = 27/103 (26%), Positives = 53/103 (51%), Gaps = 5/103 (4%)

Query: 209  VEAARQCASSPQDREKQEVLRKAA--EELRFITADYAQGQDIVGSQVARLQE--SARQAT 264
            VE+ R+ A + Q++ + +V +  A  E L  +T   A+ ++ V +   ++QE    R+  
Sbjct: 1395 VESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQ 1454

Query: 265  SSATQLIT-SAQNATQYNTNRYSQETLLEECKVLNEHLPRMVE 306
             +A +L++   +   Q    +  Q   LE+C+ + EHLP  V+
Sbjct: 1455 KAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQ 1497


>Z29064-1|CAA82305.1|  896|Homo sapiens AF-1p protein.
          Length = 896

 Score = 32.3 bits (70), Expect = 6.0
 Identities = 26/64 (40%), Positives = 35/64 (54%), Gaps = 4/64 (6%)

Query: 356 KHLADNTQLYTSSCADLRSAVSRARISCKGLELDAAAEIIKSLQEELDELEEAVRA--FD 413
           K  A+  QL +S  A+L S  S+  IS    EL  A E +  LQ+E  ELEE+V +    
Sbjct: 417 KKCAEEAQLISSLKAELTSQESQ--ISTYEEELAKAREELSRLQQETAELEESVESGKAQ 474

Query: 414 LKPL 417
           L+PL
Sbjct: 475 LEPL 478


>U07707-1|AAA52101.1|  896|Homo sapiens epidermal growth factor
           receptor substrate protein.
          Length = 896

 Score = 32.3 bits (70), Expect = 6.0
 Identities = 26/64 (40%), Positives = 35/64 (54%), Gaps = 4/64 (6%)

Query: 356 KHLADNTQLYTSSCADLRSAVSRARISCKGLELDAAAEIIKSLQEELDELEEAVRA--FD 413
           K  A+  QL +S  A+L S  S+  IS    EL  A E +  LQ+E  ELEE+V +    
Sbjct: 417 KKCAEEAQLISSLKAELTSQESQ--ISTYEEELAKAREELSRLQQETAELEESVESGKAQ 474

Query: 414 LKPL 417
           L+PL
Sbjct: 475 LEPL 478


>L14565-1|AAA60190.1|  471|Homo sapiens peripherin protein.
          Length = 471

 Score = 32.3 bits (70), Expect = 6.0
 Identities = 35/153 (22%), Positives = 70/153 (45%), Gaps = 7/153 (4%)

Query: 255 RLQESARQATSSATQLITSAQNATQYNTNRYSQETLLEECKVLNEHLPRMVEAVNVSNVK 314
           RL+E  R+   +   L+   ++      +R   E  +E      E L ++ E   + +++
Sbjct: 182 RLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEE-ELRDLQ 240

Query: 315 PTQAAARLDLISASEAFLQPSGHVISAARGALPTVSEPSAAKHLADNTQLYTSSCADLRS 374
            +  + ++  +   EA ++P    ++AA   +    E  AAK+L +  + Y S  ADL  
Sbjct: 241 VSVESQQVQQVEV-EATVKPE---LTAALRDIRAQYESIAAKNLQEAEEWYKSKYADLSD 296

Query: 375 AVSRARISCKGL--ELDAAAEIIKSLQEELDEL 405
           A +R   + +    E++ +   I+SL  E+D L
Sbjct: 297 AANRNHEALRQAKQEMNESRRQIQSLTCEVDGL 329


>DQ367924-1|ABD34786.1|  896|Homo sapiens epidermal growth factor
           receptor pathway substrate 15 protein.
          Length = 896

 Score = 32.3 bits (70), Expect = 6.0
 Identities = 26/64 (40%), Positives = 35/64 (54%), Gaps = 4/64 (6%)

Query: 356 KHLADNTQLYTSSCADLRSAVSRARISCKGLELDAAAEIIKSLQEELDELEEAVRA--FD 413
           K  A+  QL +S  A+L S  S+  IS    EL  A E +  LQ+E  ELEE+V +    
Sbjct: 417 KKCAEEAQLISSLKAELTSQESQ--ISTYEEELAKAREELSRLQQETAELEESVESGKAQ 474

Query: 414 LKPL 417
           L+PL
Sbjct: 475 LEPL 478


>BC032703-1|AAH32703.1|  470|Homo sapiens peripherin protein.
          Length = 470

 Score = 32.3 bits (70), Expect = 6.0
 Identities = 35/153 (22%), Positives = 70/153 (45%), Gaps = 7/153 (4%)

Query: 255 RLQESARQATSSATQLITSAQNATQYNTNRYSQETLLEECKVLNEHLPRMVEAVNVSNVK 314
           RL+E  R+   +   L+   ++      +R   E  +E      E L ++ E   + +++
Sbjct: 182 RLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEE-ELRDLQ 240

Query: 315 PTQAAARLDLISASEAFLQPSGHVISAARGALPTVSEPSAAKHLADNTQLYTSSCADLRS 374
            +  + ++  +   EA ++P    ++AA   +    E  AAK+L +  + Y S  ADL  
Sbjct: 241 VSVESQQVQQVEV-EATVKPE---LTAALRDIRAQYESIAAKNLQEAEEWYKSKYADLSD 296

Query: 375 AVSRARISCKGL--ELDAAAEIIKSLQEELDEL 405
           A +R   + +    E++ +   I+SL  E+D L
Sbjct: 297 AANRNHEALRQAKQEMNESRRQIQSLTCEVDGL 329


>AY358830-1|AAQ89189.1|  723|Homo sapiens leucine-rich protein
           protein.
          Length = 723

 Score = 32.3 bits (70), Expect = 6.0
 Identities = 27/113 (23%), Positives = 54/113 (47%), Gaps = 7/113 (6%)

Query: 223 EKQEVLRKAAEELRFITADYAQGQDIVGSQVARLQESARQATSSATQLITSAQNATQYNT 282
           +K E+L+   EE   +    ++ Q  + ++  RLQE  +Q   + +  I   Q   Q N 
Sbjct: 291 QKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRI---QKLLQDNQ 347

Query: 283 NRYSQETLLEECKVLNEHLPRMVEAVNVSNVKPTQAAARLDLISASEAFLQPS 335
            +     +L+  +  NE + RM + ++++  + T++  R D+ SA +  L  S
Sbjct: 348 RQKKSSEILKSLE--NERI-RMEQLMSITQ-EETESLRRRDVASAMQQMLTES 396


>AL671986-11|CAI13030.1|  896|Homo sapiens epidermal growth factor
           receptor pathway substrate 15 protein.
          Length = 896

 Score = 32.3 bits (70), Expect = 6.0
 Identities = 26/64 (40%), Positives = 35/64 (54%), Gaps = 4/64 (6%)

Query: 356 KHLADNTQLYTSSCADLRSAVSRARISCKGLELDAAAEIIKSLQEELDELEEAVRA--FD 413
           K  A+  QL +S  A+L S  S+  IS    EL  A E +  LQ+E  ELEE+V +    
Sbjct: 417 KKCAEEAQLISSLKAELTSQESQ--ISTYEEELAKAREELSRLQQETAELEESVESGKAQ 474

Query: 414 LKPL 417
           L+PL
Sbjct: 475 LEPL 478


>AL445222-17|CAH72930.1|  723|Homo sapiens leucine rich repeat and
           sterile alpha motif containing 1 protein.
          Length = 723

 Score = 32.3 bits (70), Expect = 6.0
 Identities = 27/113 (23%), Positives = 54/113 (47%), Gaps = 7/113 (6%)

Query: 223 EKQEVLRKAAEELRFITADYAQGQDIVGSQVARLQESARQATSSATQLITSAQNATQYNT 282
           +K E+L+   EE   +    ++ Q  + ++  RLQE  +Q   + +  I   Q   Q N 
Sbjct: 291 QKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRI---QKLLQDNQ 347

Query: 283 NRYSQETLLEECKVLNEHLPRMVEAVNVSNVKPTQAAARLDLISASEAFLQPS 335
            +     +L+  +  NE + RM + ++++  + T++  R D+ SA +  L  S
Sbjct: 348 RQKKSSEILKSLE--NERI-RMEQLMSITQ-EETESLRRRDVASAMQQMLTES 396


>AL445222-16|CAH72931.1|  696|Homo sapiens leucine rich repeat and
           sterile alpha motif containing 1 protein.
          Length = 696

 Score = 32.3 bits (70), Expect = 6.0
 Identities = 27/113 (23%), Positives = 54/113 (47%), Gaps = 7/113 (6%)

Query: 223 EKQEVLRKAAEELRFITADYAQGQDIVGSQVARLQESARQATSSATQLITSAQNATQYNT 282
           +K E+L+   EE   +    ++ Q  + ++  RLQE  +Q   + +  I   Q   Q N 
Sbjct: 291 QKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRI---QKLLQDNQ 347

Query: 283 NRYSQETLLEECKVLNEHLPRMVEAVNVSNVKPTQAAARLDLISASEAFLQPS 335
            +     +L+  +  NE + RM + ++++  + T++  R D+ SA +  L  S
Sbjct: 348 RQKKSSEILKSLE--NERI-RMEQLMSITQ-EETESLRRRDVASAMQQMLTES 396


>AK091589-1|BAC03703.1|  723|Homo sapiens protein ( Homo sapiens
           cDNA FLJ34270 fis, clone FEBRA2003100. ).
          Length = 723

 Score = 32.3 bits (70), Expect = 6.0
 Identities = 27/113 (23%), Positives = 54/113 (47%), Gaps = 7/113 (6%)

Query: 223 EKQEVLRKAAEELRFITADYAQGQDIVGSQVARLQESARQATSSATQLITSAQNATQYNT 282
           +K E+L+   EE   +    ++ Q  + ++  RLQE  +Q   + +  I   Q   Q N 
Sbjct: 291 QKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRI---QKLLQDNQ 347

Query: 283 NRYSQETLLEECKVLNEHLPRMVEAVNVSNVKPTQAAARLDLISASEAFLQPS 335
            +     +L+  +  NE + RM + ++++  + T++  R D+ SA +  L  S
Sbjct: 348 RQKKSSEILKSLE--NERI-RMEQLMSITQ-EETESLRRRDVASAMQQMLTES 396


>BC009239-1|AAH09239.1|  723|Homo sapiens leucine rich repeat and
           sterile alpha motif containing 1 protein.
          Length = 723

 Score = 31.9 bits (69), Expect = 7.9
 Identities = 27/113 (23%), Positives = 54/113 (47%), Gaps = 7/113 (6%)

Query: 223 EKQEVLRKAAEELRFITADYAQGQDIVGSQVARLQESARQATSSATQLITSAQNATQYNT 282
           +K E+L+   EE   +    ++ Q  + ++  RLQE  +Q   + +  I   Q   Q N 
Sbjct: 291 QKDEILQTVKEEQSRLEQGLSEHQRHLDAERQRLQEQLKQTEQNISSRI---QKLLQDNQ 347

Query: 283 NRYSQETLLEECKVLNEHLPRMVEAVNVSNVKPTQAAARLDLISASEAFLQPS 335
            +     +L+  +  NE + RM + ++++  + T++  R D+ SA +  L  S
Sbjct: 348 RQKKSSEILKSLE--NERI-RMEQLMSITQ-EETESLRRRDVASAMQQMLTES 396


>AK056203-1|BAB71119.1|  696|Homo sapiens protein ( Homo sapiens
           cDNA FLJ31641 fis, clone NT2RI2003695, weakly similar to
           TRICHOHYALIN. ).
          Length = 696

 Score = 31.9 bits (69), Expect = 7.9
 Identities = 27/113 (23%), Positives = 53/113 (46%), Gaps = 7/113 (6%)

Query: 223 EKQEVLRKAAEELRFITADYAQGQDIVGSQVARLQESARQATSSATQLITSAQNATQYNT 282
           +K E+L+   EE   +    ++ Q  + ++  RLQE  +Q   + +  I   Q   Q N 
Sbjct: 291 QKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRI---QKLLQDNQ 347

Query: 283 NRYSQETLLEECKVLNEHLPRMVEAVNVSNVKPTQAAARLDLISASEAFLQPS 335
            +     +L+  +  NE + RM + ++++  + T++  R D  SA +  L  S
Sbjct: 348 RQKKSSEILKSLE--NERI-RMEQLMSITQ-EETESLRRRDFASAMQQMLTES 396


  Database: human
    Posted date:  Oct 5, 2007 11:13 AM
  Number of letters in database: 73,234,838
  Number of sequences in database:  224,733
  
Lambda     K      H
   0.312    0.123    0.331 

Gapped
Lambda     K      H
   0.279   0.0580    0.190 


Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 70,492,667
Number of Sequences: 224733
Number of extensions: 2187910
Number of successful extensions: 5445
Number of sequences better than 10.0: 26
Number of HSP's better than 10.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 18
Number of HSP's that attempted gapping in prelim test: 5297
Number of HSP's gapped (non-prelim): 110
length of query: 697
length of database: 73,234,838
effective HSP length: 95
effective length of query: 602
effective length of database: 51,885,203
effective search space: 31234892206
effective search space used: 31234892206
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 42 (21.9 bits)
S2: 69 (31.9 bits)

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