Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001367-TA|BGIBMGA001367-PA|IPR001395|Aldo/keto reductase
(331 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
CR542203-1|CAG47000.1| 316|Homo sapiens AKR1B1 protein. 236 9e-62
CR450351-1|CAG29347.1| 316|Homo sapiens AKR1B1 protein. 235 2e-61
U05598-1|AAA20937.1| 323|Homo sapiens dihydrodiol dehydrogenase... 235 2e-61
BT006653-1|AAP35299.1| 323|Homo sapiens aldo-keto reductase fam... 235 2e-61
BC063574-1|AAH63574.1| 323|Homo sapiens aldo-keto reductase fam... 235 2e-61
BC007024-1|AAH07024.1| 323|Homo sapiens aldo-keto reductase fam... 235 2e-61
AL713867-1|CAI16408.1| 323|Homo sapiens aldo-keto reductase fam... 235 2e-61
AL391427-1|CAI14726.1| 323|Homo sapiens aldo-keto reductase fam... 235 2e-61
AB032153-1|BAA92891.1| 323|Homo sapiens bile acid-binding prote... 235 2e-61
AB031084-1|BAA92884.1| 323|Homo sapiens bile acid-binding prote... 235 2e-61
AB021654-1|BAA36169.1| 323|Homo sapiens DD2/bile acid-binding p... 235 2e-61
U05861-1|AAA18115.1| 323|Homo sapiens hepatic dihydrodiol dehyd... 234 3e-61
U05684-1|AAA16227.1| 323|Homo sapiens dihydrodiol dehydrogenase... 234 3e-61
M86609-1|AAB02880.1| 323|Homo sapiens dihydrodiol dehydrogenase... 234 3e-61
BT007197-1|AAP35861.1| 323|Homo sapiens aldo-keto reductase fam... 234 3e-61
BC040210-1|AAH40210.1| 323|Homo sapiens aldo-keto reductase fam... 234 3e-61
BC020216-1|AAH20216.1| 323|Homo sapiens aldo-keto reductase fam... 234 3e-61
BC015490-1|AAH15490.1| 323|Homo sapiens aldo-keto reductase fam... 234 3e-61
AL713867-2|CAI16409.1| 323|Homo sapiens aldo-keto reductase fam... 234 3e-61
AB032150-1|BAA92886.1| 323|Homo sapiens 20 alph-hydroxysteroid ... 234 3e-61
AB031083-1|BAA92883.1| 323|Homo sapiens 20 alpha-hydroxysteroid... 234 3e-61
X15414-1|CAA33460.1| 316|Homo sapiens protein ( Human mRNA for ... 234 4e-61
S68330-1|AAD14013.1| 323|Homo sapiens chlordecone reductase hom... 234 4e-61
M59783-1|AAA51712.1| 316|Homo sapiens aldose reductase protein. 234 4e-61
M34720-1|AAA35560.1| 316|Homo sapiens protein ( Human aldose re... 234 4e-61
L32592-1|AAB38486.1| 323|Homo sapiens dihydrodiol dehydrogenase... 234 4e-61
J05474-1|AAA51715.1| 316|Homo sapiens aldose reductase protein. 234 4e-61
J04795-1|AAA51713.1| 316|Homo sapiens ALDR1 protein. 234 4e-61
BT019859-1|AAV38662.1| 316|Homo sapiens aldo-keto reductase fam... 234 4e-61
BC010391-1|AAH10391.1| 316|Homo sapiens aldo-keto reductase fam... 234 4e-61
BC000260-1|AAH00260.1| 316|Homo sapiens aldo-keto reductase fam... 234 4e-61
AF328729-1|AAN09721.1| 316|Homo sapiens CTCL tumor antigen HD-C... 234 4e-61
AF032455-1|AAB88851.1| 316|Homo sapiens aldose reductase protein. 234 4e-61
J05017-1|AAA51714.1| 316|Homo sapiens ALDR1 protein. 233 6e-61
AF149416-1|AAF07272.2| 323|Homo sapiens 3-alpha hydroxysteroid ... 233 8e-61
J04794-1|AAA51711.1| 325|Homo sapiens ALDR1 protein. 232 1e-60
CR457010-1|CAG33291.1| 325|Homo sapiens AKR1A1 protein. 232 1e-60
BT007003-1|AAP35649.1| 325|Homo sapiens aldo-keto reductase fam... 232 1e-60
BC005394-1|AAH05394.1| 325|Homo sapiens aldo-keto reductase fam... 232 1e-60
BC000670-1|AAH00670.1| 325|Homo sapiens aldo-keto reductase fam... 232 1e-60
AL355480-3|CAI22459.1| 325|Homo sapiens aldo-keto reductase fam... 232 1e-60
AF112485-1|AAF01260.1| 325|Homo sapiens aldehyde reductase prot... 232 1e-60
AF036683-1|AAB92369.1| 325|Homo sapiens aldehyde reductase prot... 232 1e-60
Z28339-1|CAA82193.1| 326|Homo sapiens delta 4-3-oxosteroid 5 be... 232 1e-60
D17793-1|BAA04619.2| 325|Homo sapiens KIAA0119 protein. 232 1e-60
BT007286-1|AAP35950.1| 323|Homo sapiens aldo-keto reductase fam... 232 1e-60
BC130627-1|AAI30628.1| 326|Homo sapiens aldo-keto reductase fam... 232 1e-60
BC130625-1|AAI30626.1| 326|Homo sapiens aldo-keto reductase fam... 232 1e-60
BC019230-1|AAH19230.1| 323|Homo sapiens aldo-keto reductase fam... 232 1e-60
BC001479-1|AAH01479.1| 323|Homo sapiens aldo-keto reductase fam... 232 1e-60
AL391427-4|CAI14729.1| 323|Homo sapiens aldo-keto reductase fam... 232 1e-60
AF283659-1|AAG39381.1| 326|Homo sapiens 5-beta steroid reductas... 232 1e-60
AB032157-1|BAA92892.1| 323|Homo sapiens prostaglandin F synthas... 232 1e-60
AB018580-1|BAA88488.1| 323|Homo sapiens hluPGFS protein. 232 1e-60
S68288-1|AAD14011.1| 323|Homo sapiens chlordecone reductase hom... 229 8e-60
DQ269985-1|ABB76132.1| 323|Homo sapiens type II 3a-hydroxystero... 229 8e-60
S68287-1|AAD14010.1| 323|Homo sapiens chlordecone reductase pro... 229 1e-59
L43839-1|AAB41916.1| 323|Homo sapiens 3-alpha-hydroxysteroid de... 229 1e-59
D26125-1|BAA05122.1| 321|Homo sapiens 3 alpha-hydroxysteroid/di... 229 1e-59
BC020744-1|AAH20744.1| 323|Homo sapiens aldo-keto reductase fam... 229 1e-59
AB045829-1|BAA99542.1| 323|Homo sapiens 3alpha-hydroxysteroid d... 229 1e-59
AB032163-1|BAA92893.1| 323|Homo sapiens dihydrodiol dehydrogena... 229 1e-59
AB031085-1|BAA92885.1| 323|Homo sapiens dihydrodiol dehydrogena... 229 1e-59
BC005387-1|AAH05387.1| 316|Homo sapiens aldo-keto reductase fam... 228 2e-59
AL355303-2|CAI14202.1| 323|Homo sapiens aldo-keto reductase fam... 228 2e-59
S68290-1|AAD14012.1| 320|Homo sapiens chlordecone reductase hom... 227 4e-59
U37100-1|AAC17469.1| 316|Homo sapiens aldose reductase-like pep... 225 2e-58
D26124-1|BAA05121.1| 306|Homo sapiens dihydrodiol dehydrogenase... 225 2e-58
CR541801-1|CAG46600.1| 316|Homo sapiens AKR1B10 protein. 225 2e-58
BT006794-1|AAP35440.1| 316|Homo sapiens aldo-keto reductase fam... 225 2e-58
BC008837-1|AAH08837.1| 316|Homo sapiens aldo-keto reductase fam... 225 2e-58
AF052577-1|AAC36465.1| 316|Homo sapiens aldo-keto reductase pro... 224 4e-58
AF524864-1|AAO13380.1| 316|Homo sapiens aldo-ketoreductase prot... 223 7e-58
M33375-1|AAA35658.1| 308|Homo sapiens protein ( Human chlordeco... 223 9e-58
AB209796-1|BAD93033.1| 260|Homo sapiens aldo-keto reductase fam... 194 5e-49
AB209017-1|BAD92254.1| 286|Homo sapiens aldo-keto reductase fam... 182 1e-45
AL391427-2|CAI14727.1| 302|Homo sapiens aldo-keto reductase fam... 177 6e-44
AL355303-1|CAI14201.1| 302|Homo sapiens aldo-keto reductase fam... 177 6e-44
AL713867-3|CAI16410.1| 247|Homo sapiens aldo-keto reductase fam... 171 4e-42
AL355480-2|CAI22458.1| 147|Homo sapiens aldo-keto reductase fam... 125 2e-28
AB037902-1|BAA92887.1| 130|Homo sapiens truncated aldo-keto red... 116 2e-25
BC002862-1|AAH02862.1| 307|Homo sapiens AKR1CL2 protein protein. 115 2e-25
AF263242-1|AAK58523.1| 320|Homo sapiens aldo-keto reductase loo... 115 2e-25
AB055603-1|BAC54568.1| 307|Homo sapiens aldo-keto reductase rel... 115 2e-25
AB040822-1|BAC54567.1| 222|Homo sapiens aldo-keto reductase rel... 115 2e-25
AB040821-1|BAC54566.1| 263|Homo sapiens aldo-keto reductase rel... 115 2e-25
AB040820-1|BAC54565.1| 250|Homo sapiens aldo-keto reductase rel... 115 2e-25
BC101205-1|AAI01206.1| 129|Homo sapiens aldo-keto reductase fam... 113 8e-25
BC101204-1|AAI01205.1| 129|Homo sapiens aldo-keto reductase fam... 113 8e-25
AK131335-1|BAD18494.1| 129|Homo sapiens protein ( Homo sapiens ... 113 8e-25
AF044961-1|AAC15671.1| 85|Homo sapiens aldose reductase-relate... 69 2e-11
AK058142-1|BAB71682.1| 146|Homo sapiens protein ( Homo sapiens ... 65 4e-10
U33429-1|AAC50955.1| 367|Homo sapiens K+ channel beta 2 subunit... 57 8e-08
CR542287-1|CAG47082.1| 353|Homo sapiens KCNAB2 protein. 57 8e-08
BC130413-1|AAI30414.1| 367|Homo sapiens potassium voltage-gated... 57 8e-08
BC126424-1|AAI26425.1| 367|Homo sapiens potassium voltage-gated... 57 8e-08
BC110351-1|AAI10352.1| 395|Homo sapiens KCNAB2 protein protein. 57 8e-08
AL035406-6|CAI19886.1| 253|Homo sapiens potassium voltage-gated... 57 8e-08
AL035406-5|CAI19887.1| 254|Homo sapiens potassium voltage-gated... 57 8e-08
AL035406-4|CAC08512.1| 367|Homo sapiens potassium voltage-gated... 57 8e-08
AL035406-3|CAI19885.1| 353|Homo sapiens potassium voltage-gated... 57 8e-08
AF044253-1|AAB99859.1| 353|Homo sapiens potassium channel beta ... 57 8e-08
AF029749-1|AAB84170.1| 367|Homo sapiens potassium channel beta ... 57 8e-08
X83127-1|CAA58208.1| 401|Homo sapiens voltage gated potassium c... 57 1e-07
U33428-1|AAC50953.1| 401|Homo sapiens K+ channel beta 1a subuni... 57 1e-07
U16953-1|AAC50122.1| 408|Homo sapiens potassium channel beta3 s... 57 1e-07
L47665-1|AAC41926.1| 419|Homo sapiens K+ channel beta-subunit p... 57 1e-07
L39833-1|AAC37573.1| 408|Homo sapiens K+ channel beta-subunit p... 57 1e-07
BC043166-1|AAH43166.1| 401|Homo sapiens potassium voltage-gated... 57 1e-07
AK131252-1|BAD18431.1| 415|Homo sapiens protein ( Homo sapiens ... 56 1e-07
CR542264-1|CAG47060.1| 353|Homo sapiens KCNAB2 protein. 55 4e-07
BC099634-1|AAH99634.1| 404|Homo sapiens potassium voltage-gated... 48 6e-05
BC096234-1|AAH96234.1| 404|Homo sapiens potassium voltage-gated... 48 6e-05
BC096232-1|AAH96232.1| 404|Homo sapiens potassium voltage-gated... 48 6e-05
AF016411-1|AAB92499.1| 404|Homo sapiens KCNA3.1B protein. 47 8e-05
AB028065-1|BAA88489.1| 67|Homo sapiens prostaglandin F synthas... 44 0.001
AB037905-2|BAA92890.1| 45|Homo sapiens truncated aldo-keto red... 42 0.002
AF026947-1|AAC52104.1| 330|Homo sapiens aflatoxin aldehyde redu... 38 0.037
Y16675-1|CAA76347.1| 330|Homo sapiens aflatoxin B1-aldehyde red... 38 0.049
BT007347-1|AAP36011.1| 330|Homo sapiens aldo-keto reductase fam... 38 0.049
BC013996-1|AAH13996.1| 330|Homo sapiens AKR7A2 protein protein. 38 0.049
BC012171-1|AAH12171.1| 330|Homo sapiens AKR7A2 protein protein. 38 0.049
BC011586-1|AAH11586.1| 330|Homo sapiens AKR7A2 protein protein. 38 0.049
BC010852-1|AAH10852.1| 330|Homo sapiens AKR7A2 protein protein. 38 0.049
BC007352-1|AAH07352.2| 358|Homo sapiens AKR7A2 protein protein. 38 0.049
BC004111-1|AAH04111.3| 330|Homo sapiens AKR7A2 protein protein. 38 0.049
AL035413-8|CAB72321.1| 330|Homo sapiens aldo-keto reductase fam... 38 0.049
BC042420-1|AAH42420.2| 331|Homo sapiens aldo-keto reductase fam... 37 0.086
BC031562-1|AAH31562.1| 331|Homo sapiens aldo-keto reductase fam... 37 0.086
AJ278012-1|CAC79668.1| 259|Homo sapiens aflatoxin B1 aldehyde r... 37 0.086
AJ271799-1|CAC81076.1| 331|Homo sapiens aflatoxin B1 aldehyde r... 37 0.086
AF040639-1|AAD02195.1| 331|Homo sapiens aflatoxin B1-aldehyde r... 37 0.086
BC025709-1|AAH25709.1| 331|Homo sapiens aldo-keto reductase fam... 37 0.11
AL035413-11|CAI22232.1| 331|Homo sapiens aldo-keto reductase fa... 37 0.11
L35546-1|AAA65028.1| 274|Homo sapiens gamma-glutamylcysteine sy... 32 2.4
CR541833-1|CAG46632.1| 274|Homo sapiens GCLM protein. 32 2.4
BC041809-1|AAH41809.1| 274|Homo sapiens glutamate-cysteine liga... 32 2.4
AY773965-1|AAV28733.1| 274|Homo sapiens glutamate-cysteine liga... 32 2.4
AL117351-10|CAI22976.1| 274|Homo sapiens glutamate-cysteine lig... 32 2.4
AL049796-2|CAI21813.1| 274|Homo sapiens glutamate-cysteine liga... 32 2.4
>CR542203-1|CAG47000.1| 316|Homo sapiens AKR1B1 protein.
Length = 316
Score = 236 bits (577), Expect = 9e-62
Identities = 125/322 (38%), Positives = 203/322 (63%), Gaps = 22/322 (6%)
Query: 24 LAPVLKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQ 83
+A L LNNG ++P G+GTW +V ++V+ AID GYRHID A +Y E++
Sbjct: 1 MASRLLLNNGAKMPILGLGTWKSPPG------QVTEAVKVAIDVGYRHIDCAHVYQNENE 54
Query: 84 VGRAIKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPI 143
VG AI++K+ E VVKRE+LF+ +KLW T H+K V A +K+L +L LDY+DLYLIHWPI
Sbjct: 55 VGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPI 114
Query: 144 A---------LHDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEG 192
L ++ ++ S T+ ++TW AM +++++GL K+IG+SNFN Q+E + ++
Sbjct: 115 GFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKP 174
Query: 193 GV--TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFN--RQPSAPAPRADDQR 248
G+ P+V Q+E + L Q L+ YC+++GIVV AY+P G+ +P P+ +D R
Sbjct: 175 GLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPS-LLEDPR 233
Query: 249 LVAIAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFD 308
+ AIA K+ KT Q+++R+ ++ ++ IPKS+ +R+ EN +++DF L+ ++ L S++
Sbjct: 234 IKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYN 293
Query: 309 NGYRTLSPLFWAHSPYFPFESK 330
+R + L +PF +
Sbjct: 294 RNWRVCALLSCTSHKDYPFHEE 315
>CR450351-1|CAG29347.1| 316|Homo sapiens AKR1B1 protein.
Length = 316
Score = 235 bits (575), Expect = 2e-61
Identities = 125/322 (38%), Positives = 202/322 (62%), Gaps = 22/322 (6%)
Query: 24 LAPVLKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQ 83
+A L LNNG ++P G+GTW +V ++V+ AID GYRHID A +Y E++
Sbjct: 1 MASRLLLNNGAKMPILGLGTWKSPPG------QVTEAVKVAIDVGYRHIDCAHVYQNENE 54
Query: 84 VGRAIKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWP- 142
VG AI++K+ E VVKRE+LF+ +KLW T H+K V A +K+L +L LDY+DLYLIHWP
Sbjct: 55 VGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPT 114
Query: 143 --------IALHDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEG 192
L ++ ++ S T+ ++TW AM +++++GL K+IG+SNFN Q+E + S+
Sbjct: 115 GFRPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILSKP 174
Query: 193 GV--TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFN--RQPSAPAPRADDQR 248
G+ P+V Q+E + L Q L+ YC+++GIVV AY+P G+ +P P+ +D R
Sbjct: 175 GLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPS-LLEDPR 233
Query: 249 LVAIAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFD 308
+ AIA K+ KT Q+++R+ ++ ++ IPKS+ +R+ EN +++DF L+ ++ L S++
Sbjct: 234 IKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYN 293
Query: 309 NGYRTLSPLFWAHSPYFPFESK 330
+R + L +PF +
Sbjct: 294 RNWRVCALLSCTSHKDYPFHEE 315
>U05598-1|AAA20937.1| 323|Homo sapiens dihydrodiol dehydrogenase
protein.
Length = 323
Score = 235 bits (574), Expect = 2e-61
Identities = 128/319 (40%), Positives = 198/319 (62%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ E+ + ++V+ AI+AG+ HID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPA---EVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL-- 145
I+ KIA+G VKRED+F T+KLW+ +H+ E V PAL +SLKNL LDYVDLYLIH+P+++
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKP 124
Query: 146 -------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+N I D TW+AM + GL KSIGVSNFN + LE + ++ G+
Sbjct: 125 GEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + Q LLD+CK++ IV+VAY+ G+ P++P +D L A
Sbjct: 185 KPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT +E++ + +
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNV 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
R L+ +A P +PF +
Sbjct: 304 RYLTLDIFAGPPNYPFSDE 322
>BT006653-1|AAP35299.1| 323|Homo sapiens aldo-keto reductase family
1, member C2 (dihydrodiol dehydrogenase 2; bile acid
protein.
Length = 323
Score = 235 bits (574), Expect = 2e-61
Identities = 128/319 (40%), Positives = 198/319 (62%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ E+ + ++V+ AI+AG+ HID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPA---EVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL-- 145
I+ KIA+G VKRED+F T+KLW+ +H+ E V PAL +SLKNL LDYVDLYLIH+P+++
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKP 124
Query: 146 -------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+N I D TW+AM + GL KSIGVSNFN + LE + ++ G+
Sbjct: 125 GEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + Q LLD+CK++ IV+VAY+ G+ P++P +D L A
Sbjct: 185 KPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT +E++ + +
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNV 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
R L+ +A P +PF +
Sbjct: 304 RYLTLDIFAGPPNYPFSDE 322
>BC063574-1|AAH63574.1| 323|Homo sapiens aldo-keto reductase family
1, member C2 (dihydrodiol dehydrogenase 2; bile acid
protein.
Length = 323
Score = 235 bits (574), Expect = 2e-61
Identities = 128/319 (40%), Positives = 198/319 (62%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ E+ + ++V+ AI+AG+ HID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPA---EVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL-- 145
I+ KIA+G VKRED+F T+KLW+ +H+ E V PAL +SLKNL LDYVDLYLIH+P+++
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKP 124
Query: 146 -------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+N I D TW+AM + GL KSIGVSNFN + LE + ++ G+
Sbjct: 125 GEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + Q LLD+CK++ IV+VAY+ G+ P++P +D L A
Sbjct: 185 KPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT +E++ + +
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNV 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
R L+ +A P +PF +
Sbjct: 304 RYLTLDIFAGPPNYPFSDE 322
>BC007024-1|AAH07024.1| 323|Homo sapiens aldo-keto reductase family
1, member C2 (dihydrodiol dehydrogenase 2; bile acid
protein.
Length = 323
Score = 235 bits (574), Expect = 2e-61
Identities = 128/319 (40%), Positives = 198/319 (62%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ E+ + ++V+ AI+AG+ HID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPA---EVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL-- 145
I+ KIA+G VKRED+F T+KLW+ +H+ E V PAL +SLKNL LDYVDLYLIH+P+++
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKP 124
Query: 146 -------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+N I D TW+AM + GL KSIGVSNFN + LE + ++ G+
Sbjct: 125 GEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + Q LLD+CK++ IV+VAY+ G+ P++P +D L A
Sbjct: 185 KPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT +E++ + +
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNV 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
R L+ +A P +PF +
Sbjct: 304 RYLTLDIFAGPPNYPFSDE 322
>AL713867-1|CAI16408.1| 323|Homo sapiens aldo-keto reductase family
1, member C2 (dihydrodiol dehydrogenase 2; bile acid
protein.
Length = 323
Score = 235 bits (574), Expect = 2e-61
Identities = 128/319 (40%), Positives = 198/319 (62%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ E+ + ++V+ AI+AG+ HID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPA---EVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL-- 145
I+ KIA+G VKRED+F T+KLW+ +H+ E V PAL +SLKNL LDYVDLYLIH+P+++
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKP 124
Query: 146 -------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+N I D TW+AM + GL KSIGVSNFN + LE + ++ G+
Sbjct: 125 GEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + Q LLD+CK++ IV+VAY+ G+ P++P +D L A
Sbjct: 185 KPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT +E++ + +
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNV 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
R L+ +A P +PF +
Sbjct: 304 RYLTLDIFAGPPNYPFSDE 322
>AL391427-1|CAI14726.1| 323|Homo sapiens aldo-keto reductase family
1, member C2 (dihydrodiol dehydrogenase 2; bile acid
protein.
Length = 323
Score = 235 bits (574), Expect = 2e-61
Identities = 128/319 (40%), Positives = 198/319 (62%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ E+ + ++V+ AI+AG+ HID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPA---EVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL-- 145
I+ KIA+G VKRED+F T+KLW+ +H+ E V PAL +SLKNL LDYVDLYLIH+P+++
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKP 124
Query: 146 -------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+N I D TW+AM + GL KSIGVSNFN + LE + ++ G+
Sbjct: 125 GEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + Q LLD+CK++ IV+VAY+ G+ P++P +D L A
Sbjct: 185 KPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT +E++ + +
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNV 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
R L+ +A P +PF +
Sbjct: 304 RYLTLDIFAGPPNYPFSDE 322
>AB032153-1|BAA92891.1| 323|Homo sapiens bile acid-binding protein
protein.
Length = 323
Score = 235 bits (574), Expect = 2e-61
Identities = 128/319 (40%), Positives = 198/319 (62%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ E+ + ++V+ AI+AG+ HID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPA---EVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL-- 145
I+ KIA+G VKRED+F T+KLW+ +H+ E V PAL +SLKNL LDYVDLYLIH+P+++
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKP 124
Query: 146 -------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+N I D TW+AM + GL KSIGVSNFN + LE + ++ G+
Sbjct: 125 GEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + Q LLD+CK++ IV+VAY+ G+ P++P +D L A
Sbjct: 185 KPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT +E++ + +
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNV 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
R L+ +A P +PF +
Sbjct: 304 RYLTLDIFAGPPNYPFSDE 322
>AB031084-1|BAA92884.1| 323|Homo sapiens bile acid-binding protein
protein.
Length = 323
Score = 235 bits (574), Expect = 2e-61
Identities = 128/319 (40%), Positives = 198/319 (62%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ E+ + ++V+ AI+AG+ HID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPA---EVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL-- 145
I+ KIA+G VKRED+F T+KLW+ +H+ E V PAL +SLKNL LDYVDLYLIH+P+++
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKP 124
Query: 146 -------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+N I D TW+AM + GL KSIGVSNFN + LE + ++ G+
Sbjct: 125 GEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + Q LLD+CK++ IV+VAY+ G+ P++P +D L A
Sbjct: 185 KPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT +E++ + +
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNV 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
R L+ +A P +PF +
Sbjct: 304 RYLTLDIFAGPPNYPFSDE 322
>AB021654-1|BAA36169.1| 323|Homo sapiens DD2/bile acid-binding
protein/AKR1C2/3alpha-hydroxysteroid dehydrogenase type
3 protein.
Length = 323
Score = 235 bits (574), Expect = 2e-61
Identities = 128/319 (40%), Positives = 198/319 (62%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ E+ + ++V+ AI+AG+ HID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPA---EVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL-- 145
I+ KIA+G VKRED+F T+KLW+ +H+ E V PAL +SLKNL LDYVDLYLIH+P+++
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKP 124
Query: 146 -------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+N I D TW+AM + GL KSIGVSNFN + LE + ++ G+
Sbjct: 125 GEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + Q LLD+CK++ IV+VAY+ G+ P++P +D L A
Sbjct: 185 KPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT +E++ + +
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNV 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
R L+ +A P +PF +
Sbjct: 304 RYLTLDIFAGPPNYPFSDE 322
>U05861-1|AAA18115.1| 323|Homo sapiens hepatic dihydrodiol
dehydrogenase protein.
Length = 323
Score = 234 bits (573), Expect = 3e-61
Identities = 130/319 (40%), Positives = 196/319 (61%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ + K E K AI+AG+RHID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAEVPKSKALEATKL---AIEAGFRHIDSAHLYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL-- 145
I+ KIA+G VKRED+F T+KLW +H+ E V PAL +SLKNL LDYVDLYLIH+P+++
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKP 124
Query: 146 -------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+N I D TW+A+ + GL KSIGVSNFN +QLE + ++ G+
Sbjct: 125 GEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + Q LLD+CK++ IV+VAY+ G+ P++P +D L A
Sbjct: 185 KPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT +E++ + +
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNV 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
R L+ +A P +PF +
Sbjct: 304 RYLTLDIFAGPPNYPFSDE 322
>U05684-1|AAA16227.1| 323|Homo sapiens dihydrodiol dehydrogenase
protein.
Length = 323
Score = 234 bits (573), Expect = 3e-61
Identities = 130/319 (40%), Positives = 196/319 (61%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ + K E K AI+AG+RHID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAEVPKSKALEATKL---AIEAGFRHIDSAHLYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL-- 145
I+ KIA+G VKRED+F T+KLW +H+ E V PAL +SLKNL LDYVDLYLIH+P+++
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKP 124
Query: 146 -------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+N I D TW+A+ + GL KSIGVSNFN +QLE + ++ G+
Sbjct: 125 GEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + Q LLD+CK++ IV+VAY+ G+ P++P +D L A
Sbjct: 185 KPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT +E++ + +
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNV 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
R L+ +A P +PF +
Sbjct: 304 RYLTLDIFAGPPNYPFSDE 322
>M86609-1|AAB02880.1| 323|Homo sapiens dihydrodiol dehydrogenase
protein.
Length = 323
Score = 234 bits (573), Expect = 3e-61
Identities = 130/319 (40%), Positives = 196/319 (61%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ + K E K AI+AG+RHID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAEVPKSKALEATKL---AIEAGFRHIDSAHLYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL-- 145
I+ KIA+G VKRED+F T+KLW +H+ E V PAL +SLKNL LDYVDLYLIH+P+++
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKP 124
Query: 146 -------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+N I D TW+A+ + GL KSIGVSNFN +QLE + ++ G+
Sbjct: 125 GEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + Q LLD+CK++ IV+VAY+ G+ P++P +D L A
Sbjct: 185 KPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT +E++ + +
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNV 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
R L+ +A P +PF +
Sbjct: 304 RYLTLDIFAGPPNYPFSDE 322
>BT007197-1|AAP35861.1| 323|Homo sapiens aldo-keto reductase family
1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha
protein.
Length = 323
Score = 234 bits (573), Expect = 3e-61
Identities = 130/319 (40%), Positives = 196/319 (61%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ + K E K AI+AG+RHID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAEVPKSKALEATKL---AIEAGFRHIDSAHLYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL-- 145
I+ KIA+G VKRED+F T+KLW +H+ E V PAL +SLKNL LDYVDLYLIH+P+++
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKP 124
Query: 146 -------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+N I D TW+A+ + GL KSIGVSNFN +QLE + ++ G+
Sbjct: 125 GEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + Q LLD+CK++ IV+VAY+ G+ P++P +D L A
Sbjct: 185 KPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT +E++ + +
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNV 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
R L+ +A P +PF +
Sbjct: 304 RYLTLDIFAGPPNYPFSDE 322
>BC040210-1|AAH40210.1| 323|Homo sapiens aldo-keto reductase family
1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha
protein.
Length = 323
Score = 234 bits (573), Expect = 3e-61
Identities = 130/319 (40%), Positives = 196/319 (61%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ + K E K AI+AG+RHID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAEVPKSKALEATKL---AIEAGFRHIDSAHLYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL-- 145
I+ KIA+G VKRED+F T+KLW +H+ E V PAL +SLKNL LDYVDLYLIH+P+++
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKP 124
Query: 146 -------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+N I D TW+A+ + GL KSIGVSNFN +QLE + ++ G+
Sbjct: 125 GEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + Q LLD+CK++ IV+VAY+ G+ P++P +D L A
Sbjct: 185 KPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT +E++ + +
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNV 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
R L+ +A P +PF +
Sbjct: 304 RYLTLDIFAGPPNYPFSDE 322
>BC020216-1|AAH20216.1| 323|Homo sapiens aldo-keto reductase family
1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha
protein.
Length = 323
Score = 234 bits (573), Expect = 3e-61
Identities = 130/319 (40%), Positives = 196/319 (61%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ + K E K AI+AG+RHID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAEVPKSKALEATKL---AIEAGFRHIDSAHLYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL-- 145
I+ KIA+G VKRED+F T+KLW +H+ E V PAL +SLKNL LDYVDLYLIH+P+++
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKP 124
Query: 146 -------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+N I D TW+A+ + GL KSIGVSNFN +QLE + ++ G+
Sbjct: 125 GEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + Q LLD+CK++ IV+VAY+ G+ P++P +D L A
Sbjct: 185 KPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT +E++ + +
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNV 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
R L+ +A P +PF +
Sbjct: 304 RYLTLDIFAGPPNYPFSDE 322
>BC015490-1|AAH15490.1| 323|Homo sapiens aldo-keto reductase family
1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha
protein.
Length = 323
Score = 234 bits (573), Expect = 3e-61
Identities = 130/319 (40%), Positives = 196/319 (61%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ + K E K AI+AG+RHID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAEVPKSKALEATKL---AIEAGFRHIDSAHLYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL-- 145
I+ KIA+G VKRED+F T+KLW +H+ E V PAL +SLKNL LDYVDLYLIH+P+++
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKP 124
Query: 146 -------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+N I D TW+A+ + GL KSIGVSNFN +QLE + ++ G+
Sbjct: 125 GEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + Q LLD+CK++ IV+VAY+ G+ P++P +D L A
Sbjct: 185 KPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT +E++ + +
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNV 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
R L+ +A P +PF +
Sbjct: 304 RYLTLDIFAGPPNYPFSDE 322
>AL713867-2|CAI16409.1| 323|Homo sapiens aldo-keto reductase family
1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha
protein.
Length = 323
Score = 234 bits (573), Expect = 3e-61
Identities = 130/319 (40%), Positives = 196/319 (61%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ + K E K AI+AG+RHID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAEVPKSKALEATKL---AIEAGFRHIDSAHLYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL-- 145
I+ KIA+G VKRED+F T+KLW +H+ E V PAL +SLKNL LDYVDLYLIH+P+++
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKP 124
Query: 146 -------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+N I D TW+A+ + GL KSIGVSNFN +QLE + ++ G+
Sbjct: 125 GEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + Q LLD+CK++ IV+VAY+ G+ P++P +D L A
Sbjct: 185 KPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT +E++ + +
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNV 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
R L+ +A P +PF +
Sbjct: 304 RYLTLDIFAGPPNYPFSDE 322
>AB032150-1|BAA92886.1| 323|Homo sapiens 20 alph-hydroxysteroid
dehydrogenase protein.
Length = 323
Score = 234 bits (573), Expect = 3e-61
Identities = 130/319 (40%), Positives = 196/319 (61%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ + K E K AI+AG+RHID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAEVPKSKALEATKL---AIEAGFRHIDSAHLYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL-- 145
I+ KIA+G VKRED+F T+KLW +H+ E V PAL +SLKNL LDYVDLYLIH+P+++
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKP 124
Query: 146 -------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+N I D TW+A+ + GL KSIGVSNFN +QLE + ++ G+
Sbjct: 125 GEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + Q LLD+CK++ IV+VAY+ G+ P++P +D L A
Sbjct: 185 KPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT +E++ + +
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNV 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
R L+ +A P +PF +
Sbjct: 304 RYLTLDIFAGPPNYPFSDE 322
>AB031083-1|BAA92883.1| 323|Homo sapiens 20 alpha-hydroxysteroid
dehydrogenase protein.
Length = 323
Score = 234 bits (573), Expect = 3e-61
Identities = 130/319 (40%), Positives = 196/319 (61%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ + K E K AI+AG+RHID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAEVPKSKALEATKL---AIEAGFRHIDSAHLYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL-- 145
I+ KIA+G VKRED+F T+KLW +H+ E V PAL +SLKNL LDYVDLYLIH+P+++
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKP 124
Query: 146 -------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+N I D TW+A+ + GL KSIGVSNFN +QLE + ++ G+
Sbjct: 125 GEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + Q LLD+CK++ IV+VAY+ G+ P++P +D L A
Sbjct: 185 KPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT +E++ + +
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNV 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
R L+ +A P +PF +
Sbjct: 304 RYLTLDIFAGPPNYPFSDE 322
>X15414-1|CAA33460.1| 316|Homo sapiens protein ( Human mRNA for
aldose reductase (EC 1.1.1.2). ).
Length = 316
Score = 234 bits (572), Expect = 4e-61
Identities = 124/322 (38%), Positives = 202/322 (62%), Gaps = 22/322 (6%)
Query: 24 LAPVLKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQ 83
+A L LNNG ++P G+GTW +V ++V+ AID GYRHID A +Y E++
Sbjct: 1 MASRLLLNNGAKMPILGLGTWKSPPG------QVTEAVKVAIDVGYRHIDCAHVYQNENE 54
Query: 84 VGRAIKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWP- 142
VG AI++K+ E VVKRE+LF+ +KLW T H+K V A +K+L +L LDY+DLYLIHWP
Sbjct: 55 VGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPT 114
Query: 143 --------IALHDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEG 192
L ++ ++ S T+ ++TW AM +++++GL K+IG+SNFN Q+E + ++
Sbjct: 115 GFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKP 174
Query: 193 GV--TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFN--RQPSAPAPRADDQR 248
G+ P+V Q+E + L Q L+ YC+++GIVV AY+P G+ +P P+ +D R
Sbjct: 175 GLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPS-LLEDPR 233
Query: 249 LVAIAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFD 308
+ AIA K+ KT Q+++R+ ++ ++ IPKS+ +R+ EN +++DF L+ ++ L S++
Sbjct: 234 IKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYN 293
Query: 309 NGYRTLSPLFWAHSPYFPFESK 330
+R + L +PF +
Sbjct: 294 RNWRVCALLSCTSHKDYPFHEE 315
>S68330-1|AAD14013.1| 323|Homo sapiens chlordecone reductase
homolog protein.
Length = 323
Score = 234 bits (572), Expect = 4e-61
Identities = 128/319 (40%), Positives = 197/319 (61%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ E+ + ++V+ AI+AG+ HID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPA---EVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL-- 145
I+ KIA+G VKRED+F T+KLW+ +H+ E V PAL +SLKNL LDYVDLYLIH+P+++
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKP 124
Query: 146 -------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+N I D TW+AM + GL KSIGVSNFN + LE + +E G+
Sbjct: 125 GEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNEPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + Q LLD+CK++ IV+VAY+ G+ P++P +D L A
Sbjct: 185 EPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT +E++ + +
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNV 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
R L+ +A P +P +
Sbjct: 304 RYLTLDIFAGPPNYPISDE 322
>M59783-1|AAA51712.1| 316|Homo sapiens aldose reductase protein.
Length = 316
Score = 234 bits (572), Expect = 4e-61
Identities = 124/322 (38%), Positives = 202/322 (62%), Gaps = 22/322 (6%)
Query: 24 LAPVLKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQ 83
+A L LNNG ++P G+GTW +V ++V+ AID GYRHID A +Y E++
Sbjct: 1 MASRLLLNNGAKMPILGLGTWKSPPG------QVTEAVKVAIDVGYRHIDCAHVYQNENE 54
Query: 84 VGRAIKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWP- 142
VG AI++K+ E VVKRE+LF+ +KLW T H+K V A +K+L +L LDY+DLYLIHWP
Sbjct: 55 VGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPT 114
Query: 143 --------IALHDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEG 192
L ++ ++ S T+ ++TW AM +++++GL K+IG+SNFN Q+E + ++
Sbjct: 115 GFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKP 174
Query: 193 GV--TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFN--RQPSAPAPRADDQR 248
G+ P+V Q+E + L Q L+ YC+++GIVV AY+P G+ +P P+ +D R
Sbjct: 175 GLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPS-LLEDPR 233
Query: 249 LVAIAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFD 308
+ AIA K+ KT Q+++R+ ++ ++ IPKS+ +R+ EN +++DF L+ ++ L S++
Sbjct: 234 IKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYN 293
Query: 309 NGYRTLSPLFWAHSPYFPFESK 330
+R + L +PF +
Sbjct: 294 RNWRVCALLSCTSHKDYPFHEE 315
>M34720-1|AAA35560.1| 316|Homo sapiens protein ( Human aldose
reductase mRNA, complete cds. ).
Length = 316
Score = 234 bits (572), Expect = 4e-61
Identities = 124/322 (38%), Positives = 202/322 (62%), Gaps = 22/322 (6%)
Query: 24 LAPVLKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQ 83
+A L LNNG ++P G+GTW +V ++V+ AID GYRHID A +Y E++
Sbjct: 1 MASRLLLNNGAKMPILGLGTWKSPPG------QVTEAVKVAIDVGYRHIDCAHVYQNENE 54
Query: 84 VGRAIKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWP- 142
VG AI++K+ E VVKRE+LF+ +KLW T H+K V A +K+L +L LDY+DLYLIHWP
Sbjct: 55 VGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPT 114
Query: 143 --------IALHDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEG 192
L ++ ++ S T+ ++TW AM +++++GL K+IG+SNFN Q+E + ++
Sbjct: 115 GFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKP 174
Query: 193 GV--TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFN--RQPSAPAPRADDQR 248
G+ P+V Q+E + L Q L+ YC+++GIVV AY+P G+ +P P+ +D R
Sbjct: 175 GLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPS-LLEDPR 233
Query: 249 LVAIAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFD 308
+ AIA K+ KT Q+++R+ ++ ++ IPKS+ +R+ EN +++DF L+ ++ L S++
Sbjct: 234 IKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYN 293
Query: 309 NGYRTLSPLFWAHSPYFPFESK 330
+R + L +PF +
Sbjct: 294 RNWRVCALLSCTSHKDYPFHEE 315
>L32592-1|AAB38486.1| 323|Homo sapiens dihydrodiol
dehydrogenase/bile acid-binding protein protein.
Length = 323
Score = 234 bits (572), Expect = 4e-61
Identities = 128/319 (40%), Positives = 196/319 (61%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ E+ + ++V+ AI+AGY HID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPA---EVPKSKALEAVKLAIEAGYHHIDSAHVYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL-- 145
I+ KIA+G VKRED+F T+KLW+ +H+ E V PAL +SLKNL LDY DLYLIH+P+++
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYADLYLIHFPVSVKP 124
Query: 146 -------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+N I D TW+AM + GL KSIGVSNFN + LE + +E G+
Sbjct: 125 GEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNEPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + Q LLD+CK++ IV+VAY+ G+ P++P +D L A
Sbjct: 185 EPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT +E++ + +
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNV 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
R L+ +A P +P +
Sbjct: 304 RYLTLDIFAGPPNYPISDE 322
>J05474-1|AAA51715.1| 316|Homo sapiens aldose reductase protein.
Length = 316
Score = 234 bits (572), Expect = 4e-61
Identities = 124/322 (38%), Positives = 202/322 (62%), Gaps = 22/322 (6%)
Query: 24 LAPVLKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQ 83
+A L LNNG ++P G+GTW +V ++V+ AID GYRHID A +Y E++
Sbjct: 1 MASRLLLNNGAKMPILGLGTWKSPPG------QVTEAVKVAIDVGYRHIDCAHVYQNENE 54
Query: 84 VGRAIKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWP- 142
VG AI++K+ E VVKRE+LF+ +KLW T H+K V A +K+L +L LDY+DLYLIHWP
Sbjct: 55 VGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPT 114
Query: 143 --------IALHDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEG 192
L ++ ++ S T+ ++TW AM +++++GL K+IG+SNFN Q+E + ++
Sbjct: 115 GFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKP 174
Query: 193 GV--TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFN--RQPSAPAPRADDQR 248
G+ P+V Q+E + L Q L+ YC+++GIVV AY+P G+ +P P+ +D R
Sbjct: 175 GLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPS-LLEDPR 233
Query: 249 LVAIAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFD 308
+ AIA K+ KT Q+++R+ ++ ++ IPKS+ +R+ EN +++DF L+ ++ L S++
Sbjct: 234 IKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYN 293
Query: 309 NGYRTLSPLFWAHSPYFPFESK 330
+R + L +PF +
Sbjct: 294 RNWRVCALLSCTSHKDYPFHEE 315
>J04795-1|AAA51713.1| 316|Homo sapiens ALDR1 protein.
Length = 316
Score = 234 bits (572), Expect = 4e-61
Identities = 124/322 (38%), Positives = 202/322 (62%), Gaps = 22/322 (6%)
Query: 24 LAPVLKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQ 83
+A L LNNG ++P G+GTW +V ++V+ AID GYRHID A +Y E++
Sbjct: 1 MASRLLLNNGAKMPILGLGTWKSPPG------QVTEAVKVAIDVGYRHIDCAHVYQNENE 54
Query: 84 VGRAIKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWP- 142
VG AI++K+ E VVKRE+LF+ +KLW T H+K V A +K+L +L LDY+DLYLIHWP
Sbjct: 55 VGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPT 114
Query: 143 --------IALHDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEG 192
L ++ ++ S T+ ++TW AM +++++GL K+IG+SNFN Q+E + ++
Sbjct: 115 GFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKP 174
Query: 193 GV--TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFN--RQPSAPAPRADDQR 248
G+ P+V Q+E + L Q L+ YC+++GIVV AY+P G+ +P P+ +D R
Sbjct: 175 GLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPS-LLEDPR 233
Query: 249 LVAIAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFD 308
+ AIA K+ KT Q+++R+ ++ ++ IPKS+ +R+ EN +++DF L+ ++ L S++
Sbjct: 234 IKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYN 293
Query: 309 NGYRTLSPLFWAHSPYFPFESK 330
+R + L +PF +
Sbjct: 294 RNWRVCALLSCTSHKDYPFHEE 315
>BT019859-1|AAV38662.1| 316|Homo sapiens aldo-keto reductase family
1, member B1 (aldose reductase) protein.
Length = 316
Score = 234 bits (572), Expect = 4e-61
Identities = 124/322 (38%), Positives = 202/322 (62%), Gaps = 22/322 (6%)
Query: 24 LAPVLKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQ 83
+A L LNNG ++P G+GTW +V ++V+ AID GYRHID A +Y E++
Sbjct: 1 MASRLLLNNGAKMPILGLGTWKSPPG------QVTEAVKVAIDVGYRHIDCAHVYQNENE 54
Query: 84 VGRAIKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWP- 142
VG AI++K+ E VVKRE+LF+ +KLW T H+K V A +K+L +L LDY+DLYLIHWP
Sbjct: 55 VGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPT 114
Query: 143 --------IALHDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEG 192
L ++ ++ S T+ ++TW AM +++++GL K+IG+SNFN Q+E + ++
Sbjct: 115 GFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKP 174
Query: 193 GV--TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFN--RQPSAPAPRADDQR 248
G+ P+V Q+E + L Q L+ YC+++GIVV AY+P G+ +P P+ +D R
Sbjct: 175 GLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPS-LLEDPR 233
Query: 249 LVAIAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFD 308
+ AIA K+ KT Q+++R+ ++ ++ IPKS+ +R+ EN +++DF L+ ++ L S++
Sbjct: 234 IKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYN 293
Query: 309 NGYRTLSPLFWAHSPYFPFESK 330
+R + L +PF +
Sbjct: 294 RNWRVCALLSCTSHKDYPFHEE 315
>BC010391-1|AAH10391.1| 316|Homo sapiens aldo-keto reductase family
1, member B1 (aldose reductase) protein.
Length = 316
Score = 234 bits (572), Expect = 4e-61
Identities = 124/322 (38%), Positives = 202/322 (62%), Gaps = 22/322 (6%)
Query: 24 LAPVLKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQ 83
+A L LNNG ++P G+GTW +V ++V+ AID GYRHID A +Y E++
Sbjct: 1 MASRLLLNNGAKMPILGLGTWKSPPG------QVTEAVKVAIDVGYRHIDCAHVYQNENE 54
Query: 84 VGRAIKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWP- 142
VG AI++K+ E VVKRE+LF+ +KLW T H+K V A +K+L +L LDY+DLYLIHWP
Sbjct: 55 VGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPT 114
Query: 143 --------IALHDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEG 192
L ++ ++ S T+ ++TW AM +++++GL K+IG+SNFN Q+E + ++
Sbjct: 115 GFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKP 174
Query: 193 GV--TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFN--RQPSAPAPRADDQR 248
G+ P+V Q+E + L Q L+ YC+++GIVV AY+P G+ +P P+ +D R
Sbjct: 175 GLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPS-LLEDPR 233
Query: 249 LVAIAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFD 308
+ AIA K+ KT Q+++R+ ++ ++ IPKS+ +R+ EN +++DF L+ ++ L S++
Sbjct: 234 IKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYN 293
Query: 309 NGYRTLSPLFWAHSPYFPFESK 330
+R + L +PF +
Sbjct: 294 RNWRVCALLSCTSHKDYPFHEE 315
>BC000260-1|AAH00260.1| 316|Homo sapiens aldo-keto reductase family
1, member B1 (aldose reductase) protein.
Length = 316
Score = 234 bits (572), Expect = 4e-61
Identities = 124/322 (38%), Positives = 202/322 (62%), Gaps = 22/322 (6%)
Query: 24 LAPVLKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQ 83
+A L LNNG ++P G+GTW +V ++V+ AID GYRHID A +Y E++
Sbjct: 1 MASRLLLNNGAKMPILGLGTWKSPPG------QVTEAVKVAIDVGYRHIDCAHVYQNENE 54
Query: 84 VGRAIKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWP- 142
VG AI++K+ E VVKRE+LF+ +KLW T H+K V A +K+L +L LDY+DLYLIHWP
Sbjct: 55 VGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPT 114
Query: 143 --------IALHDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEG 192
L ++ ++ S T+ ++TW AM +++++GL K+IG+SNFN Q+E + ++
Sbjct: 115 GFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKP 174
Query: 193 GV--TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFN--RQPSAPAPRADDQR 248
G+ P+V Q+E + L Q L+ YC+++GIVV AY+P G+ +P P+ +D R
Sbjct: 175 GLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPS-LLEDPR 233
Query: 249 LVAIAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFD 308
+ AIA K+ KT Q+++R+ ++ ++ IPKS+ +R+ EN +++DF L+ ++ L S++
Sbjct: 234 IKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYN 293
Query: 309 NGYRTLSPLFWAHSPYFPFESK 330
+R + L +PF +
Sbjct: 294 RNWRVCALLSCTSHKDYPFHEE 315
>AF328729-1|AAN09721.1| 316|Homo sapiens CTCL tumor antigen
HD-CL-07 protein.
Length = 316
Score = 234 bits (572), Expect = 4e-61
Identities = 124/322 (38%), Positives = 202/322 (62%), Gaps = 22/322 (6%)
Query: 24 LAPVLKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQ 83
+A L LNNG ++P G+GTW +V ++V+ AID GYRHID A +Y E++
Sbjct: 1 MASRLLLNNGAKMPILGLGTWKSPPG------QVTEAVKVAIDVGYRHIDCAHVYQNENE 54
Query: 84 VGRAIKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWP- 142
VG AI++K+ E VVKRE+LF+ +KLW T H+K V A +K+L +L LDY+DLYLIHWP
Sbjct: 55 VGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPT 114
Query: 143 --------IALHDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEG 192
L ++ ++ S T+ ++TW AM +++++GL K+IG+SNFN Q+E + ++
Sbjct: 115 GFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKP 174
Query: 193 GV--TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFN--RQPSAPAPRADDQR 248
G+ P+V Q+E + L Q L+ YC+++GIVV AY+P G+ +P P+ +D R
Sbjct: 175 GLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPS-LLEDPR 233
Query: 249 LVAIAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFD 308
+ AIA K+ KT Q+++R+ ++ ++ IPKS+ +R+ EN +++DF L+ ++ L S++
Sbjct: 234 IKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYN 293
Query: 309 NGYRTLSPLFWAHSPYFPFESK 330
+R + L +PF +
Sbjct: 294 RNWRVCALLSCTSHKDYPFHEE 315
>AF032455-1|AAB88851.1| 316|Homo sapiens aldose reductase protein.
Length = 316
Score = 234 bits (572), Expect = 4e-61
Identities = 124/322 (38%), Positives = 202/322 (62%), Gaps = 22/322 (6%)
Query: 24 LAPVLKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQ 83
+A L LNNG ++P G+GTW +V ++V+ AID GYRHID A +Y E++
Sbjct: 1 MASRLLLNNGAKMPILGLGTWKSPPG------QVTEAVKVAIDVGYRHIDCAHVYQNENE 54
Query: 84 VGRAIKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWP- 142
VG AI++K+ E VVKRE+LF+ +KLW T H+K V A +K+L +L LDY+DLYLIHWP
Sbjct: 55 VGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPT 114
Query: 143 --------IALHDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEG 192
L ++ ++ S T+ ++TW AM +++++GL K+IG+SNFN Q+E + ++
Sbjct: 115 GFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKP 174
Query: 193 GV--TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFN--RQPSAPAPRADDQR 248
G+ P+V Q+E + L Q L+ YC+++GIVV AY+P G+ +P P+ +D R
Sbjct: 175 GLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPS-LLEDPR 233
Query: 249 LVAIAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFD 308
+ AIA K+ KT Q+++R+ ++ ++ IPKS+ +R+ EN +++DF L+ ++ L S++
Sbjct: 234 IKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYN 293
Query: 309 NGYRTLSPLFWAHSPYFPFESK 330
+R + L +PF +
Sbjct: 294 RNWRVCALLSCTSHKDYPFHEE 315
>J05017-1|AAA51714.1| 316|Homo sapiens ALDR1 protein.
Length = 316
Score = 233 bits (570), Expect = 6e-61
Identities = 123/322 (38%), Positives = 202/322 (62%), Gaps = 22/322 (6%)
Query: 24 LAPVLKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQ 83
+A + LNNG ++P G+GTW +V ++V+ AID GYRHID A +Y E++
Sbjct: 1 MASRILLNNGAKMPILGLGTWKSPPG------QVTEAVKVAIDVGYRHIDCAHVYQNENE 54
Query: 84 VGRAIKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWP- 142
VG AI++K+ E VVKRE+LF+ +KLW T H+K V A +K+L +L LDY+DLYLIHWP
Sbjct: 55 VGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPT 114
Query: 143 --------IALHDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEG 192
L ++ ++ S T+ ++TW AM +++++GL K+IG+SNFN Q+E + ++
Sbjct: 115 GFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKP 174
Query: 193 GV--TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFN--RQPSAPAPRADDQR 248
G+ P+V Q+E + L Q L+ YC+++GIVV AY+P G+ +P P+ +D R
Sbjct: 175 GLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPS-LLEDPR 233
Query: 249 LVAIAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFD 308
+ AIA K+ KT Q+++R+ ++ ++ IPKS+ +R+ EN +++DF L+ ++ L S++
Sbjct: 234 IKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYN 293
Query: 309 NGYRTLSPLFWAHSPYFPFESK 330
+R + L +PF +
Sbjct: 294 RNWRVCALLSCTSHKDYPFHEE 315
>AF149416-1|AAF07272.2| 323|Homo sapiens 3-alpha hydroxysteroid
dehydrogenase type IIb protein.
Length = 323
Score = 233 bits (569), Expect = 8e-61
Identities = 127/319 (39%), Positives = 195/319 (61%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ K EV K AI+AG+RHID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPPEVPRSKALEVSKL---AIEAGFRHIDSAHLYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIALHD 147
I+ KIA+G VKRED+F T+KLW+T+H+ E V PAL SLK LDYVDLYLIH P++L
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWSTSHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKP 124
Query: 148 NASISQT-----------DYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+S T D TW+AM + GL KSIGVSNFN +QLE + ++ G+
Sbjct: 125 GEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNRQ---PSAPAPRADDQRLVA 251
P QVE + + LLD+CK++ IV+VAY+ G+ +++ P++P +D L A
Sbjct: 185 KPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + +S ++ R+ +N+Q+++F LT ++++ + D
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLARSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNL 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
+ +A P +P+ +
Sbjct: 304 HYFNSDSFASHPNYPYSDE 322
>J04794-1|AAA51711.1| 325|Homo sapiens ALDR1 protein.
Length = 325
Score = 232 bits (568), Expect = 1e-60
Identities = 121/307 (39%), Positives = 196/307 (63%), Gaps = 21/307 (6%)
Query: 25 APVLKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQV 84
A + L+ G+++P G+GTW + + +V+ +V++A+ GYRHID AAIY E ++
Sbjct: 3 ASCVLLHTGQKMPLIGLGTW------KSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEI 56
Query: 85 GRAIKKKIAEG-VVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPI 143
G A+K+ + G V RE+LFVT+KLWNT H E V PALRK+L +L L+Y+DLYL+HWP
Sbjct: 57 GEALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPY 116
Query: 144 ALH--DNA---------SISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEG 192
A DN T Y ETW+A+ ++ +GL +++G+SNFN +Q++ + S
Sbjct: 117 AFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVA 176
Query: 193 GVTPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFN--RQPSAPAPRADDQRLV 250
V P+VLQVE + L Q L+ +C+A+G+ V AY+P G+ R P P ++ ++
Sbjct: 177 SVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPV-LLEEPVVL 235
Query: 251 AIAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNG 310
A+A+KY ++ QI+LR+ V+ VI IPKS+ R+ +NI+++DF+ +P+E++ L + +
Sbjct: 236 ALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKN 295
Query: 311 YRTLSPL 317
+R + P+
Sbjct: 296 WRYIVPM 302
>CR457010-1|CAG33291.1| 325|Homo sapiens AKR1A1 protein.
Length = 325
Score = 232 bits (568), Expect = 1e-60
Identities = 121/307 (39%), Positives = 196/307 (63%), Gaps = 21/307 (6%)
Query: 25 APVLKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQV 84
A + L+ G+++P G+GTW + + +V+ +V++A+ GYRHID AAIY E ++
Sbjct: 3 ASCVLLHTGQKMPLIGLGTW------KSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEI 56
Query: 85 GRAIKKKIAEG-VVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPI 143
G A+K+ + G V RE+LFVT+KLWNT H E V PALRK+L +L L+Y+DLYL+HWP
Sbjct: 57 GEALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPY 116
Query: 144 ALH--DNA---------SISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEG 192
A DN T Y ETW+A+ ++ +GL +++G+SNFN +Q++ + S
Sbjct: 117 AFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVA 176
Query: 193 GVTPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFN--RQPSAPAPRADDQRLV 250
V P+VLQVE + L Q L+ +C+A+G+ V AY+P G+ R P P ++ ++
Sbjct: 177 SVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPV-LLEEPVVL 235
Query: 251 AIAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNG 310
A+A+KY ++ QI+LR+ V+ VI IPKS+ R+ +NI+++DF+ +P+E++ L + +
Sbjct: 236 ALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKN 295
Query: 311 YRTLSPL 317
+R + P+
Sbjct: 296 WRYIVPM 302
>BT007003-1|AAP35649.1| 325|Homo sapiens aldo-keto reductase family
1, member A1 (aldehyde reductase) protein.
Length = 325
Score = 232 bits (568), Expect = 1e-60
Identities = 121/307 (39%), Positives = 196/307 (63%), Gaps = 21/307 (6%)
Query: 25 APVLKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQV 84
A + L+ G+++P G+GTW + + +V+ +V++A+ GYRHID AAIY E ++
Sbjct: 3 ASCVLLHTGQKMPLIGLGTW------KSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEI 56
Query: 85 GRAIKKKIAEG-VVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPI 143
G A+K+ + G V RE+LFVT+KLWNT H E V PALRK+L +L L+Y+DLYL+HWP
Sbjct: 57 GEALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPY 116
Query: 144 ALH--DNA---------SISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEG 192
A DN T Y ETW+A+ ++ +GL +++G+SNFN +Q++ + S
Sbjct: 117 AFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVA 176
Query: 193 GVTPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFN--RQPSAPAPRADDQRLV 250
V P+VLQVE + L Q L+ +C+A+G+ V AY+P G+ R P P ++ ++
Sbjct: 177 SVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPV-LLEEPVVL 235
Query: 251 AIAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNG 310
A+A+KY ++ QI+LR+ V+ VI IPKS+ R+ +NI+++DF+ +P+E++ L + +
Sbjct: 236 ALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKN 295
Query: 311 YRTLSPL 317
+R + P+
Sbjct: 296 WRYIVPM 302
>BC005394-1|AAH05394.1| 325|Homo sapiens aldo-keto reductase family
1, member A1 (aldehyde reductase) protein.
Length = 325
Score = 232 bits (568), Expect = 1e-60
Identities = 121/307 (39%), Positives = 196/307 (63%), Gaps = 21/307 (6%)
Query: 25 APVLKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQV 84
A + L+ G+++P G+GTW + + +V+ +V++A+ GYRHID AAIY E ++
Sbjct: 3 ASCVLLHTGQKMPLIGLGTW------KSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEI 56
Query: 85 GRAIKKKIAEG-VVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPI 143
G A+K+ + G V RE+LFVT+KLWNT H E V PALRK+L +L L+Y+DLYL+HWP
Sbjct: 57 GEALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPY 116
Query: 144 ALH--DNA---------SISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEG 192
A DN T Y ETW+A+ ++ +GL +++G+SNFN +Q++ + S
Sbjct: 117 AFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVA 176
Query: 193 GVTPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFN--RQPSAPAPRADDQRLV 250
V P+VLQVE + L Q L+ +C+A+G+ V AY+P G+ R P P ++ ++
Sbjct: 177 SVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPV-LLEEPVVL 235
Query: 251 AIAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNG 310
A+A+KY ++ QI+LR+ V+ VI IPKS+ R+ +NI+++DF+ +P+E++ L + +
Sbjct: 236 ALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKN 295
Query: 311 YRTLSPL 317
+R + P+
Sbjct: 296 WRYIVPM 302
>BC000670-1|AAH00670.1| 325|Homo sapiens aldo-keto reductase family
1, member A1 (aldehyde reductase) protein.
Length = 325
Score = 232 bits (568), Expect = 1e-60
Identities = 121/307 (39%), Positives = 196/307 (63%), Gaps = 21/307 (6%)
Query: 25 APVLKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQV 84
A + L+ G+++P G+GTW + + +V+ +V++A+ GYRHID AAIY E ++
Sbjct: 3 ASCVLLHTGQKMPLIGLGTW------KSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEI 56
Query: 85 GRAIKKKIAEG-VVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPI 143
G A+K+ + G V RE+LFVT+KLWNT H E V PALRK+L +L L+Y+DLYL+HWP
Sbjct: 57 GEALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPY 116
Query: 144 ALH--DNA---------SISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEG 192
A DN T Y ETW+A+ ++ +GL +++G+SNFN +Q++ + S
Sbjct: 117 AFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVA 176
Query: 193 GVTPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFN--RQPSAPAPRADDQRLV 250
V P+VLQVE + L Q L+ +C+A+G+ V AY+P G+ R P P ++ ++
Sbjct: 177 SVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPV-LLEEPVVL 235
Query: 251 AIAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNG 310
A+A+KY ++ QI+LR+ V+ VI IPKS+ R+ +NI+++DF+ +P+E++ L + +
Sbjct: 236 ALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKN 295
Query: 311 YRTLSPL 317
+R + P+
Sbjct: 296 WRYIVPM 302
>AL355480-3|CAI22459.1| 325|Homo sapiens aldo-keto reductase family
1, member A1 (aldehydetase, 1 protein.
Length = 325
Score = 232 bits (568), Expect = 1e-60
Identities = 121/307 (39%), Positives = 196/307 (63%), Gaps = 21/307 (6%)
Query: 25 APVLKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQV 84
A + L+ G+++P G+GTW + + +V+ +V++A+ GYRHID AAIY E ++
Sbjct: 3 ASCVLLHTGQKMPLIGLGTW------KSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEI 56
Query: 85 GRAIKKKIAEG-VVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPI 143
G A+K+ + G V RE+LFVT+KLWNT H E V PALRK+L +L L+Y+DLYL+HWP
Sbjct: 57 GEALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPY 116
Query: 144 ALH--DNA---------SISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEG 192
A DN T Y ETW+A+ ++ +GL +++G+SNFN +Q++ + S
Sbjct: 117 AFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVA 176
Query: 193 GVTPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFN--RQPSAPAPRADDQRLV 250
V P+VLQVE + L Q L+ +C+A+G+ V AY+P G+ R P P ++ ++
Sbjct: 177 SVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPV-LLEEPVVL 235
Query: 251 AIAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNG 310
A+A+KY ++ QI+LR+ V+ VI IPKS+ R+ +NI+++DF+ +P+E++ L + +
Sbjct: 236 ALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKN 295
Query: 311 YRTLSPL 317
+R + P+
Sbjct: 296 WRYIVPM 302
>AF112485-1|AAF01260.1| 325|Homo sapiens aldehyde reductase
protein.
Length = 325
Score = 232 bits (568), Expect = 1e-60
Identities = 121/307 (39%), Positives = 196/307 (63%), Gaps = 21/307 (6%)
Query: 25 APVLKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQV 84
A + L+ G+++P G+GTW + + +V+ +V++A+ GYRHID AAIY E ++
Sbjct: 3 ASCVLLHTGQKMPLIGLGTW------KSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEI 56
Query: 85 GRAIKKKIAEG-VVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPI 143
G A+K+ + G V RE+LFVT+KLWNT H E V PALRK+L +L L+Y+DLYL+HWP
Sbjct: 57 GEALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPY 116
Query: 144 ALH--DNA---------SISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEG 192
A DN T Y ETW+A+ ++ +GL +++G+SNFN +Q++ + S
Sbjct: 117 AFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVA 176
Query: 193 GVTPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFN--RQPSAPAPRADDQRLV 250
V P+VLQVE + L Q L+ +C+A+G+ V AY+P G+ R P P ++ ++
Sbjct: 177 SVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPV-LLEEPVVL 235
Query: 251 AIAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNG 310
A+A+KY ++ QI+LR+ V+ VI IPKS+ R+ +NI+++DF+ +P+E++ L + +
Sbjct: 236 ALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKN 295
Query: 311 YRTLSPL 317
+R + P+
Sbjct: 296 WRYIVPM 302
>AF036683-1|AAB92369.1| 325|Homo sapiens aldehyde reductase
protein.
Length = 325
Score = 232 bits (568), Expect = 1e-60
Identities = 121/307 (39%), Positives = 196/307 (63%), Gaps = 21/307 (6%)
Query: 25 APVLKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQV 84
A + L+ G+++P G+GTW + + +V+ +V++A+ GYRHID AAIY E ++
Sbjct: 3 ASCVLLHTGQKMPLIGLGTW------KSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEI 56
Query: 85 GRAIKKKIAEG-VVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPI 143
G A+K+ + G V RE+LFVT+KLWNT H E V PALRK+L +L L+Y+DLYL+HWP
Sbjct: 57 GEALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPY 116
Query: 144 ALH--DNA---------SISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEG 192
A DN T Y ETW+A+ ++ +GL +++G+SNFN +Q++ + S
Sbjct: 117 AFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVA 176
Query: 193 GVTPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFN--RQPSAPAPRADDQRLV 250
V P+VLQVE + L Q L+ +C+A+G+ V AY+P G+ R P P ++ ++
Sbjct: 177 SVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPV-LLEEPVVL 235
Query: 251 AIAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNG 310
A+A+KY ++ QI+LR+ V+ VI IPKS+ R+ +NI+++DF+ +P+E++ L + +
Sbjct: 236 ALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKN 295
Query: 311 YRTLSPL 317
+R + P+
Sbjct: 296 WRYIVPM 302
>Z28339-1|CAA82193.1| 326|Homo sapiens delta 4-3-oxosteroid 5
beta-reductase protein.
Length = 326
Score = 232 bits (567), Expect = 1e-60
Identities = 132/319 (41%), Positives = 188/319 (58%), Gaps = 19/319 (5%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+ L++G IP G+GT+ S KG SV+ AID GYRHID A IY E +VG A
Sbjct: 10 IPLSDGNSIPIIGLGTYSEPKSTP-KG-ACATSVKVAIDTGYRHIDGAYIYQNEHEVGEA 67
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIALHD 147
I++KIAEG V+RED+F KLW TNH E V P L ++L+ L LDYVDLY+I P+A
Sbjct: 68 IREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKP 127
Query: 148 NASI-----------SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
I +++ TW+AM + GL KS+GVSNFN +QLE + ++ G+
Sbjct: 128 GDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKH 187
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + QP LL +C+ IV+ AY+P G N S+P P D L +
Sbjct: 188 KPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSP-PLLKDALLNS 246
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+ ++Y KT QIVLR+ ++ GV+ IPKS + +R++EN QI+DFSLT +E++ +++ +
Sbjct: 247 LGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNV 306
Query: 312 RTLSPLFWAHSPYFPFESK 330
R + L W P +PF +
Sbjct: 307 RFVELLMWRDHPEYPFHDE 325
>D17793-1|BAA04619.2| 325|Homo sapiens KIAA0119 protein.
Length = 325
Score = 232 bits (567), Expect = 1e-60
Identities = 128/319 (40%), Positives = 194/319 (60%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ K EV K AI+AG+RHID+A +Y+ E+QVG A
Sbjct: 10 VKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKL---AIEAGFRHIDSAHLYNNEEQVGLA 66
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIALHD 147
I+ KIA+G VKRED+F T+KLW+T H+ E V PAL SLK LDYVDLYLIH P++L
Sbjct: 67 IRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKP 126
Query: 148 NASISQT-----------DYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+S T D TW+AM + GL KSIGVSNFN +QLE + ++ G+
Sbjct: 127 GEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKY 186
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNRQ---PSAPAPRADDQRLVA 251
P QVE + + LLD+CK++ IV+VAY+ G+ +++ P++P +D L A
Sbjct: 187 KPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPV-LLEDPVLCA 245
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT ++++ + D
Sbjct: 246 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNL 305
Query: 312 RTLSPLFWAHSPYFPFESK 330
+ +A P +P+ +
Sbjct: 306 HYFNSDSFASHPNYPYSDE 324
>BT007286-1|AAP35950.1| 323|Homo sapiens aldo-keto reductase family
1, member C3 (3-alpha hydroxysteroid dehydrogenase,
protein.
Length = 323
Score = 232 bits (567), Expect = 1e-60
Identities = 128/319 (40%), Positives = 194/319 (60%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ K EV K AI+AG+RHID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKL---AIEAGFRHIDSAHLYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIALHD 147
I+ KIA+G VKRED+F T+KLW+T H+ E V PAL SLK LDYVDLYLIH P++L
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKP 124
Query: 148 NASISQT-----------DYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+S T D TW+AM + GL KSIGVSNFN +QLE + ++ G+
Sbjct: 125 GEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNRQ---PSAPAPRADDQRLVA 251
P QVE + + LLD+CK++ IV+VAY+ G+ +++ P++P +D L A
Sbjct: 185 KPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT ++++ + D
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNL 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
+ +A P +P+ +
Sbjct: 304 HYFNSDSFASHPNYPYSDE 322
>BC130627-1|AAI30628.1| 326|Homo sapiens aldo-keto reductase family
1, member D1 (delta 4-3-ketosteroid-5-beta-reductase
protein.
Length = 326
Score = 232 bits (567), Expect = 1e-60
Identities = 132/319 (41%), Positives = 188/319 (58%), Gaps = 19/319 (5%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+ L++G IP G+GT+ S KG SV+ AID GYRHID A IY E +VG A
Sbjct: 10 IPLSDGNSIPIIGLGTYSEPKSTP-KG-ACATSVKVAIDTGYRHIDGAYIYQNEHEVGEA 67
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIALHD 147
I++KIAEG V+RED+F KLW TNH E V P L ++L+ L LDYVDLY+I P+A
Sbjct: 68 IREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKP 127
Query: 148 NASI-----------SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
I +++ TW+AM + GL KS+GVSNFN +QLE + ++ G+
Sbjct: 128 GDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKH 187
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + QP LL +C+ IV+ AY+P G N S+P P D L +
Sbjct: 188 KPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSP-PLLKDALLNS 246
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+ ++Y KT QIVLR+ ++ GV+ IPKS + +R++EN QI+DFSLT +E++ +++ +
Sbjct: 247 LGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNV 306
Query: 312 RTLSPLFWAHSPYFPFESK 330
R + L W P +PF +
Sbjct: 307 RFVELLMWRDHPEYPFHDE 325
>BC130625-1|AAI30626.1| 326|Homo sapiens aldo-keto reductase family
1, member D1 (delta 4-3-ketosteroid-5-beta-reductase
protein.
Length = 326
Score = 232 bits (567), Expect = 1e-60
Identities = 132/319 (41%), Positives = 188/319 (58%), Gaps = 19/319 (5%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+ L++G IP G+GT+ S KG SV+ AID GYRHID A IY E +VG A
Sbjct: 10 IPLSDGNSIPIIGLGTYSEPKSTP-KG-ACATSVKVAIDTGYRHIDGAYIYQNEHEVGEA 67
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIALHD 147
I++KIAEG V+RED+F KLW TNH E V P L ++L+ L LDYVDLY+I P+A
Sbjct: 68 IREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKP 127
Query: 148 NASI-----------SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
I +++ TW+AM + GL KS+GVSNFN +QLE + ++ G+
Sbjct: 128 GDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKH 187
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + QP LL +C+ IV+ AY+P G N S+P P D L +
Sbjct: 188 KPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSP-PLLKDALLNS 246
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+ ++Y KT QIVLR+ ++ GV+ IPKS + +R++EN QI+DFSLT +E++ +++ +
Sbjct: 247 LGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNV 306
Query: 312 RTLSPLFWAHSPYFPFESK 330
R + L W P +PF +
Sbjct: 307 RFVELLMWRDHPEYPFHDE 325
>BC019230-1|AAH19230.1| 323|Homo sapiens aldo-keto reductase family
1, member C3 (3-alpha hydroxysteroid dehydrogenase,
protein.
Length = 323
Score = 232 bits (567), Expect = 1e-60
Identities = 128/319 (40%), Positives = 194/319 (60%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ K EV K AI+AG+RHID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKL---AIEAGFRHIDSAHLYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIALHD 147
I+ KIA+G VKRED+F T+KLW+T H+ E V PAL SLK LDYVDLYLIH P++L
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKP 124
Query: 148 NASISQT-----------DYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+S T D TW+AM + GL KSIGVSNFN +QLE + ++ G+
Sbjct: 125 GEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNRQ---PSAPAPRADDQRLVA 251
P QVE + + LLD+CK++ IV+VAY+ G+ +++ P++P +D L A
Sbjct: 185 KPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT ++++ + D
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNL 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
+ +A P +P+ +
Sbjct: 304 HYFNSDSFASHPNYPYSDE 322
>BC001479-1|AAH01479.1| 323|Homo sapiens aldo-keto reductase family
1, member C3 (3-alpha hydroxysteroid dehydrogenase,
protein.
Length = 323
Score = 232 bits (567), Expect = 1e-60
Identities = 128/319 (40%), Positives = 194/319 (60%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ K EV K AI+AG+RHID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKL---AIEAGFRHIDSAHLYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIALHD 147
I+ KIA+G VKRED+F T+KLW+T H+ E V PAL SLK LDYVDLYLIH P++L
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKP 124
Query: 148 NASISQT-----------DYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+S T D TW+AM + GL KSIGVSNFN +QLE + ++ G+
Sbjct: 125 GEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNRQ---PSAPAPRADDQRLVA 251
P QVE + + LLD+CK++ IV+VAY+ G+ +++ P++P +D L A
Sbjct: 185 KPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT ++++ + D
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNL 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
+ +A P +P+ +
Sbjct: 304 HYFNSDSFASHPNYPYSDE 322
>AL391427-4|CAI14729.1| 323|Homo sapiens aldo-keto reductase family
1, member C3 (3-alpha hydroxysteroid dehydrogenase,
protein.
Length = 323
Score = 232 bits (567), Expect = 1e-60
Identities = 128/319 (40%), Positives = 194/319 (60%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ K EV K AI+AG+RHID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKL---AIEAGFRHIDSAHLYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIALHD 147
I+ KIA+G VKRED+F T+KLW+T H+ E V PAL SLK LDYVDLYLIH P++L
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKP 124
Query: 148 NASISQT-----------DYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+S T D TW+AM + GL KSIGVSNFN +QLE + ++ G+
Sbjct: 125 GEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNRQ---PSAPAPRADDQRLVA 251
P QVE + + LLD+CK++ IV+VAY+ G+ +++ P++P +D L A
Sbjct: 185 KPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT ++++ + D
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNL 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
+ +A P +P+ +
Sbjct: 304 HYFNSDSFASHPNYPYSDE 322
>AF283659-1|AAG39381.1| 326|Homo sapiens 5-beta steroid reductase
protein.
Length = 326
Score = 232 bits (567), Expect = 1e-60
Identities = 132/319 (41%), Positives = 188/319 (58%), Gaps = 19/319 (5%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+ L++G IP G+GT+ S KG SV+ AID GYRHID A IY E +VG A
Sbjct: 10 IPLSDGNSIPIIGLGTYSEPKSTP-KG-ACATSVKVAIDTGYRHIDGAYIYQNEHEVGEA 67
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIALHD 147
I++KIAEG V+RED+F KLW TNH E V P L ++L+ L LDYVDLY+I P+A
Sbjct: 68 IREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKP 127
Query: 148 NASI-----------SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
I +++ TW+AM + GL KS+GVSNFN +QLE + ++ G+
Sbjct: 128 GDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKH 187
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + QP LL +C+ IV+ AY+P G N S+P P D L +
Sbjct: 188 KPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSP-PLLKDALLNS 246
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+ ++Y KT QIVLR+ ++ GV+ IPKS + +R++EN QI+DFSLT +E++ +++ +
Sbjct: 247 LGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNV 306
Query: 312 RTLSPLFWAHSPYFPFESK 330
R + L W P +PF +
Sbjct: 307 RFVELLMWRDHPEYPFHDE 325
>AB032157-1|BAA92892.1| 323|Homo sapiens prostaglandin F synthase
protein.
Length = 323
Score = 232 bits (567), Expect = 1e-60
Identities = 128/319 (40%), Positives = 194/319 (60%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ K EV K AI+AG+RHID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKL---AIEAGFRHIDSAHLYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIALHD 147
I+ KIA+G VKRED+F T+KLW+T H+ E V PAL SLK LDYVDLYLIH P++L
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKP 124
Query: 148 NASISQT-----------DYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+S T D TW+AM + GL KSIGVSNFN +QLE + ++ G+
Sbjct: 125 GEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNRQ---PSAPAPRADDQRLVA 251
P QVE + + LLD+CK++ IV+VAY+ G+ +++ P++P +D L A
Sbjct: 185 KPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT ++++ + D
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNL 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
+ +A P +P+ +
Sbjct: 304 HYFNSDSFASHPNYPYSDE 322
>AB018580-1|BAA88488.1| 323|Homo sapiens hluPGFS protein.
Length = 323
Score = 232 bits (567), Expect = 1e-60
Identities = 128/319 (40%), Positives = 194/319 (60%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ K EV K AI+AG+RHID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKL---AIEAGFRHIDSAHLYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIALHD 147
I+ KIA+G VKRED+F T+KLW+T H+ E V PAL SLK LDYVDLYLIH P++L
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKP 124
Query: 148 NASISQT-----------DYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+S T D TW+AM + GL KSIGVSNFN +QLE + ++ G+
Sbjct: 125 GEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNRQ---PSAPAPRADDQRLVA 251
P QVE + + LLD+CK++ IV+VAY+ G+ +++ P++P +D L A
Sbjct: 185 KPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT ++++ + D
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNL 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
+ +A P +P+ +
Sbjct: 304 HYFNSDSFASHPNYPYSDE 322
>S68288-1|AAD14011.1| 323|Homo sapiens chlordecone reductase
homolog protein.
Length = 323
Score = 229 bits (561), Expect = 8e-60
Identities = 127/319 (39%), Positives = 194/319 (60%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ K EV K AI+AG+RHID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKL---AIEAGFRHIDSAHLYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIALHD 147
I+ KIA+G V+RED+F T+KLW+T H+ E V PAL SLK LDYVDLYLIH P++L
Sbjct: 65 IRSKIADGSVEREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKP 124
Query: 148 NASISQT-----------DYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+S T D TW+AM + GL KSIGVSNFN +QLE + ++ G+
Sbjct: 125 GEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEIILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNRQ---PSAPAPRADDQRLVA 251
P QVE + + LLD+CK++ IV+VAY+ G+ +++ P++P +D L A
Sbjct: 185 KPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT ++++ + D
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNL 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
+ +A P +P+ +
Sbjct: 304 HYFNSDSFASHPNYPYSDE 322
>DQ269985-1|ABB76132.1| 323|Homo sapiens type II 3a-hydroxysteroid
dehydrogenase variant protein.
Length = 323
Score = 229 bits (561), Expect = 8e-60
Identities = 125/319 (39%), Positives = 194/319 (60%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ + K E K AI+AG+RHID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAEVPKSKALEATKL---AIEAGFRHIDSAHLYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIALHD 147
++ KIA+G VKRED+F T+KLW +H+ E V PAL +SLK LDYVDLYLIH P++L
Sbjct: 65 VRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKKAQLDYVDLYLIHSPMSLKP 124
Query: 148 NASISQT-----------DYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+S T D TW+AM + GL KSIGVSNFN +QLE + ++ G+
Sbjct: 125 GEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNRQ---PSAPAPRADDQRLVA 251
P QVE + + LLD+CK++ IV+VAY+ G+ +++ P++P +D L A
Sbjct: 185 KPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT ++++ + D
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNL 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
+ +A P +P+ +
Sbjct: 304 HYFNSDSFASHPNYPYSDE 322
>S68287-1|AAD14010.1| 323|Homo sapiens chlordecone reductase
protein.
Length = 323
Score = 229 bits (559), Expect = 1e-59
Identities = 129/319 (40%), Positives = 194/319 (60%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
++LN+G +P G GT+ + EV K AI+AG+RHID+A +Y+ E+QVG A
Sbjct: 8 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKL---AIEAGFRHIDSAYLYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL-- 145
I+ KIA+G VKRED+F T+KLW T + + V PAL SLK L LDYVDLYL+H+P+AL
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKP 124
Query: 146 -------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+N + D TW+ M + GL KSIGVSNFN +QLE + ++ G+
Sbjct: 125 GETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + L Q LLD+CK++ IV+VA++ G ++ P++P +D L A
Sbjct: 185 KPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ ENIQ+++F LT +++++L + Y
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNY 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
R + F P +PF +
Sbjct: 304 RYVVMDFLMDHPDYPFSDE 322
>L43839-1|AAB41916.1| 323|Homo sapiens 3-alpha-hydroxysteroid
dehydrogenase protein.
Length = 323
Score = 229 bits (559), Expect = 1e-59
Identities = 127/319 (39%), Positives = 193/319 (60%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ K EV K AI+AG+RHID+A +Y+ E+QVG A
Sbjct: 8 VKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKL---AIEAGFRHIDSAHLYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIALHD 147
I+ KIA+G V RED+F T+KLW+T H+ E V PAL SLK LDYVDLYLIH P++L
Sbjct: 65 IRSKIADGSVMREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKP 124
Query: 148 NASISQT-----------DYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+S T D TW+AM + GL KSIGVSNFN +QLE + ++ G+
Sbjct: 125 GEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEIILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNRQ---PSAPAPRADDQRLVA 251
P QVE + + LLD+CK++ IV+VAY+ G+ +++ P++P +D L A
Sbjct: 185 KPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT ++++ + D
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNL 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
+ +A P +P+ +
Sbjct: 304 HYFNSDSFASHPNYPYSDE 322
>D26125-1|BAA05122.1| 321|Homo sapiens 3
alpha-hydroxysteroid/dihydrodiol dehydrogenase DD4
protein.
Length = 321
Score = 229 bits (559), Expect = 1e-59
Identities = 129/319 (40%), Positives = 194/319 (60%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
++LN+G +P G GT+ + EV K AI+AG+RHID+A +Y+ E+QVG A
Sbjct: 6 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKL---AIEAGFRHIDSAYLYNNEEQVGLA 62
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL-- 145
I+ KIA+G VKRED+F T+KLW T + + V PAL SLK L LDYVDLYL+H+P+AL
Sbjct: 63 IRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKP 122
Query: 146 -------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+N + D TW+ M + GL KSIGVSNFN +QLE + ++ G+
Sbjct: 123 GETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKY 182
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + L Q LLD+CK++ IV+VA++ G ++ P++P +D L A
Sbjct: 183 KPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPV-LLEDPVLCA 241
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ ENIQ+++F LT +++++L + Y
Sbjct: 242 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNY 301
Query: 312 RTLSPLFWAHSPYFPFESK 330
R + F P +PF +
Sbjct: 302 RYVVMDFLMDHPDYPFSDE 320
>BC020744-1|AAH20744.1| 323|Homo sapiens aldo-keto reductase family
1, member C4 (chlordecone reductase; 3-alpha hydroxy
protein.
Length = 323
Score = 229 bits (559), Expect = 1e-59
Identities = 129/319 (40%), Positives = 194/319 (60%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
++LN+G +P G GT+ + EV K AI+AG+RHID+A +Y+ E+QVG A
Sbjct: 8 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKL---AIEAGFRHIDSAYLYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL-- 145
I+ KIA+G VKRED+F T+KLW T + + V PAL SLK L LDYVDLYL+H+P+AL
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKP 124
Query: 146 -------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+N + D TW+ M + GL KSIGVSNFN +QLE + ++ G+
Sbjct: 125 GETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + L Q LLD+CK++ IV+VA++ G ++ P++P +D L A
Sbjct: 185 KPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ ENIQ+++F LT +++++L + Y
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNY 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
R + F P +PF +
Sbjct: 304 RYVVMDFLMDHPDYPFSDE 322
>AB045829-1|BAA99542.1| 323|Homo sapiens 3alpha-hydroxysteroid
dehydrogenase variant protein.
Length = 323
Score = 229 bits (559), Expect = 1e-59
Identities = 129/319 (40%), Positives = 194/319 (60%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
++LN+G +P G GT+ + EV K AI+AG+RHID+A +Y+ E+QVG A
Sbjct: 8 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKL---AIEAGFRHIDSAYLYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL-- 145
I+ KIA+G VKRED+F T+KLW T + + V PAL SLK L LDYVDLYL+H+P+AL
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKP 124
Query: 146 -------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+N + D TW+ M + GL KSIGVSNFN +QLE + ++ G+
Sbjct: 125 GETPLPKDENGKVIFDTVDLCATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + L Q LLD+CK++ IV+VA++ G ++ P++P +D L A
Sbjct: 185 KPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ ENIQ+++F LT +++++L + Y
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNY 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
R + F P +PF +
Sbjct: 304 RYVVMDFVMDHPDYPFSDE 322
>AB032163-1|BAA92893.1| 323|Homo sapiens dihydrodiol dehydrogenase
4 protein.
Length = 323
Score = 229 bits (559), Expect = 1e-59
Identities = 129/319 (40%), Positives = 194/319 (60%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
++LN+G +P G GT+ + EV K AI+AG+RHID+A +Y+ E+QVG A
Sbjct: 8 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKL---AIEAGFRHIDSAYLYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL-- 145
I+ KIA+G VKRED+F T+KLW T + + V PAL SLK L LDYVDLYL+H+P+AL
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKP 124
Query: 146 -------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+N + D TW+ M + GL KSIGVSNFN +QLE + ++ G+
Sbjct: 125 GETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + L Q LLD+CK++ IV+VA++ G ++ P++P +D L A
Sbjct: 185 KPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ ENIQ+++F LT +++++L + Y
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNY 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
R + F P +PF +
Sbjct: 304 RYVVMDFLMDHPDYPFSDE 322
>AB031085-1|BAA92885.1| 323|Homo sapiens dihydrodiol dehydrogenase
4 protein.
Length = 323
Score = 229 bits (559), Expect = 1e-59
Identities = 129/319 (40%), Positives = 194/319 (60%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
++LN+G +P G GT+ + EV K AI+AG+RHID+A +Y+ E+QVG A
Sbjct: 8 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKL---AIEAGFRHIDSAYLYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL-- 145
I+ KIA+G VKRED+F T+KLW T + + V PAL SLK L LDYVDLYL+H+P+AL
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKP 124
Query: 146 -------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+N + D TW+ M + GL KSIGVSNFN +QLE + ++ G+
Sbjct: 125 GETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + L Q LLD+CK++ IV+VA++ G ++ P++P +D L A
Sbjct: 185 KPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ ENIQ+++F LT +++++L + Y
Sbjct: 244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNY 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
R + F P +PF +
Sbjct: 304 RYVVMDFLMDHPDYPFSDE 322
>BC005387-1|AAH05387.1| 316|Homo sapiens aldo-keto reductase family
1, member B1 (aldose reductase) protein.
Length = 316
Score = 228 bits (558), Expect = 2e-59
Identities = 123/322 (38%), Positives = 201/322 (62%), Gaps = 22/322 (6%)
Query: 24 LAPVLKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQ 83
+A L LNNG ++P G+GTW +V ++V+ AID GYRHID A +Y E++
Sbjct: 1 MASRLLLNNGAKMPILGLGTWKSPPG------QVTEAVKVAIDVGYRHIDCAHVYQNENE 54
Query: 84 VGRAIKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWP- 142
VG AI++K+ E VVKRE+LF+ +KLW T H+K V A +K+L +L LDY+DLYLIHWP
Sbjct: 55 VGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPT 114
Query: 143 --------IALHDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEG 192
L ++ ++ S T+ ++T AM +++++GL K+IG+SNFN Q+E + ++
Sbjct: 115 GFKPGKEFFPLDESGNVVPSDTNILDTRAAMEELVDEGLVKAIGISNFNHLQVEMILNKP 174
Query: 193 GV--TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFN--RQPSAPAPRADDQR 248
G+ P+V Q+E + L Q L+ YC+++GIVV AY+P G+ +P P+ +D R
Sbjct: 175 GLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPS-LLEDPR 233
Query: 249 LVAIAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFD 308
+ AIA K+ KT Q+++R+ ++ ++ IPKS+ +R+ EN +++DF L+ ++ L S++
Sbjct: 234 IKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYN 293
Query: 309 NGYRTLSPLFWAHSPYFPFESK 330
+R + L +PF +
Sbjct: 294 RNWRVCALLSCTSHKDYPFHEE 315
>AL355303-2|CAI14202.1| 323|Homo sapiens aldo-keto reductase family
1, member C4 (chlordecone reductase; 3-alpha hydroxy
protein.
Length = 323
Score = 228 bits (558), Expect = 2e-59
Identities = 129/319 (40%), Positives = 194/319 (60%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
++LN+G +P G GT+ + EV K AI+AG+RHID+A +Y+ E+QVG A
Sbjct: 8 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKL---AIEAGFRHIDSAYLYNNEEQVGLA 64
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL-- 145
I+ KIA+G VKRED+F T+KLW T + + V PAL SLK L LDYVDLYL+H+P+AL
Sbjct: 65 IRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKP 124
Query: 146 -------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+N + D TW+ M + GL KSIGVSNFN +QLE + ++ G+
Sbjct: 125 GETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKY 184
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + L Q LLD+CK++ IV+VA++ G ++ P++P +D L A
Sbjct: 185 KPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPV-LLEDPVLCA 243
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ ENIQ+++F LT +++++L + Y
Sbjct: 244 LAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNY 303
Query: 312 RTLSPLFWAHSPYFPFESK 330
R + F P +PF +
Sbjct: 304 RYVVMDFLMDHPDYPFSDE 322
>S68290-1|AAD14012.1| 320|Homo sapiens chlordecone reductase
homolog protein.
Length = 320
Score = 227 bits (555), Expect = 4e-59
Identities = 128/319 (40%), Positives = 192/319 (60%), Gaps = 20/319 (6%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ + K E K AI+AG+RHID+A +Y+ E+QVG A
Sbjct: 5 VKLNDGHFMPVLGFGTYAPAEVPKSKALEATKL---AIEAGFRHIDSAHLYNNEEQVGLA 61
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL-- 145
I+ KIA+G VKRED+F T+KLW +H+ E PAL +SLKNL LDYVDLYLIH+P+++
Sbjct: 62 IRSKIADGSVKREDIFYTSKLWCNSHRPELDRPALERSLKNLQLDYVDLYLIHFPVSVKP 121
Query: 146 -------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGG--V 194
+N I D TW+A+ + L KSIGVSNFN LE + ++ G V
Sbjct: 122 GEEVIPKDENGKILFDTVDLCATWEAVEKCKDAELAKSIGVSNFNRSTLEMILNKPGLQV 181
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + Q LLD+CK++ IV+VAY+ G+L P++P +D L A
Sbjct: 182 KPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSLREEPWVDPNSPV-LLEDPVLCA 240
Query: 252 IAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGY 311
+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+Q+++F LT +E++ + +
Sbjct: 241 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNV 300
Query: 312 RTLSPLFWAHSPYFPFESK 330
R L+ +A P +P +
Sbjct: 301 RYLTLDIFAGPPNYPISDE 319
>U37100-1|AAC17469.1| 316|Homo sapiens aldose reductase-like
peptide protein.
Length = 316
Score = 225 bits (549), Expect = 2e-58
Identities = 121/322 (37%), Positives = 197/322 (61%), Gaps = 22/322 (6%)
Query: 24 LAPVLKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQ 83
+A ++L+ ++P G+GTW +V+++V+ AIDAGYRHID A +Y E +
Sbjct: 1 MATFVELSTKAKMPIVGLGTWKSPLG------KVKEAVKVAIDAGYRHIDCAYVYQNEHE 54
Query: 84 VGRAIKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPI 143
VG AI++KI E VKREDLF+ +KLW T ++ V A K+LK+L L Y+D+YLIHWP
Sbjct: 55 VGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQ 114
Query: 144 ALHD-----------NASISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEG 192
NA + +++ W+AM +++++GL K++GVSNF+ Q+E+L ++
Sbjct: 115 GFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKP 174
Query: 193 GV--TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFN--RQPSAPAPRADDQR 248
G+ P QVE + L Q L+ YC ++GI V AY+P G+ +P P+ +D +
Sbjct: 175 GLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPS-LLEDPK 233
Query: 249 LVAIAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFD 308
+ IA K+KKT Q+++R+ ++ VI IPKS+ R+ ENIQ++DF L+ +E+ + SF+
Sbjct: 234 IKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFN 293
Query: 309 NGYRTLSPLFWAHSPYFPFESK 330
+R + L +H +PF+++
Sbjct: 294 RNWRACNVLQSSHLEDYPFDAE 315
>D26124-1|BAA05121.1| 306|Homo sapiens dihydrodiol dehydrogenase
isoform DD1 protein.
Length = 306
Score = 225 bits (549), Expect = 2e-58
Identities = 125/307 (40%), Positives = 188/307 (61%), Gaps = 20/307 (6%)
Query: 40 GIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRAIKKKIAEGVVKR 99
G GT+ + K E K AI+AG+RHID+A +Y+ E+QVG AI+ KIA+G VKR
Sbjct: 3 GFGTYAPAEVPKSKALEATKL---AIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKR 59
Query: 100 EDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL---------HDNAS 150
ED+F T+KLW +H+ E V PAL +SLKNL LDYVDLYLIH+P+++ +N
Sbjct: 60 EDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGK 119
Query: 151 I--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV--TPSVLQVEINLN 206
I D TW+A+ + GL KSIGVSNFN +QLE + ++ G+ P QVE +
Sbjct: 120 ILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPY 179
Query: 207 LQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVAIAQKYKKTVPQI 263
Q LLD+CK++ IV+VAY+ G+ P++P +D L A+A+K+K+T I
Sbjct: 180 FNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPV-LLEDPVLCALAKKHKRTPALI 238
Query: 264 VLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGYRTLSPLFWAHSP 323
LRY ++ GV+ + KS ++ R+ +N+Q+++F LT +E++ + + R L+ +A P
Sbjct: 239 ALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPP 298
Query: 324 YFPFESK 330
+PF +
Sbjct: 299 NYPFSDE 305
>CR541801-1|CAG46600.1| 316|Homo sapiens AKR1B10 protein.
Length = 316
Score = 225 bits (549), Expect = 2e-58
Identities = 121/322 (37%), Positives = 197/322 (61%), Gaps = 22/322 (6%)
Query: 24 LAPVLKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQ 83
+A ++L+ ++P G+GTW +V+++V+ AIDAGYRHID A +Y E +
Sbjct: 1 MATFVELSTKAKMPIVGLGTWKSPLG------KVKEAVKVAIDAGYRHIDCAYVYQNEHE 54
Query: 84 VGRAIKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPI 143
VG AI++KI E VKREDLF+ +KLW T ++ V A K+LK+L L Y+D+YLIHWP
Sbjct: 55 VGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQ 114
Query: 144 ALHD-----------NASISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEG 192
NA + +++ W+AM +++++GL K++GVSNF+ Q+E+L ++
Sbjct: 115 GFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKP 174
Query: 193 GV--TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFN--RQPSAPAPRADDQR 248
G+ P QVE + L Q L+ YC ++GI V AY+P G+ +P P+ +D +
Sbjct: 175 GLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPS-LLEDPK 233
Query: 249 LVAIAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFD 308
+ IA K+KKT Q+++R+ ++ VI IPKS+ R+ ENIQ++DF L+ +E+ + SF+
Sbjct: 234 IKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFN 293
Query: 309 NGYRTLSPLFWAHSPYFPFESK 330
+R + L +H +PF+++
Sbjct: 294 RNWRACNVLQSSHLEDYPFDAE 315
>BT006794-1|AAP35440.1| 316|Homo sapiens aldo-keto reductase family
1, member B10 (aldose reductase) protein.
Length = 316
Score = 225 bits (549), Expect = 2e-58
Identities = 121/322 (37%), Positives = 197/322 (61%), Gaps = 22/322 (6%)
Query: 24 LAPVLKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQ 83
+A ++L+ ++P G+GTW +V+++V+ AIDAGYRHID A +Y E +
Sbjct: 1 MATFVELSTKAKMPIVGLGTWKSPLG------KVKEAVKVAIDAGYRHIDCAYVYQNEHE 54
Query: 84 VGRAIKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPI 143
VG AI++KI E VKREDLF+ +KLW T ++ V A K+LK+L L Y+D+YLIHWP
Sbjct: 55 VGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQ 114
Query: 144 ALHD-----------NASISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEG 192
NA + +++ W+AM +++++GL K++GVSNF+ Q+E+L ++
Sbjct: 115 GFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKP 174
Query: 193 GV--TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFN--RQPSAPAPRADDQR 248
G+ P QVE + L Q L+ YC ++GI V AY+P G+ +P P+ +D +
Sbjct: 175 GLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPS-LLEDPK 233
Query: 249 LVAIAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFD 308
+ IA K+KKT Q+++R+ ++ VI IPKS+ R+ ENIQ++DF L+ +E+ + SF+
Sbjct: 234 IKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFN 293
Query: 309 NGYRTLSPLFWAHSPYFPFESK 330
+R + L +H +PF+++
Sbjct: 294 RNWRACNVLQSSHLEDYPFDAE 315
>BC008837-1|AAH08837.1| 316|Homo sapiens aldo-keto reductase family
1, member B10 (aldose reductase) protein.
Length = 316
Score = 225 bits (549), Expect = 2e-58
Identities = 121/322 (37%), Positives = 197/322 (61%), Gaps = 22/322 (6%)
Query: 24 LAPVLKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQ 83
+A ++L+ ++P G+GTW +V+++V+ AIDAGYRHID A +Y E +
Sbjct: 1 MATFVELSTKAKMPIVGLGTWKSPLG------KVKEAVKVAIDAGYRHIDCAYVYQNEHE 54
Query: 84 VGRAIKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPI 143
VG AI++KI E VKREDLF+ +KLW T ++ V A K+LK+L L Y+D+YLIHWP
Sbjct: 55 VGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQ 114
Query: 144 ALHD-----------NASISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEG 192
NA + +++ W+AM +++++GL K++GVSNF+ Q+E+L ++
Sbjct: 115 GFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKP 174
Query: 193 GV--TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFN--RQPSAPAPRADDQR 248
G+ P QVE + L Q L+ YC ++GI V AY+P G+ +P P+ +D +
Sbjct: 175 GLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPS-LLEDPK 233
Query: 249 LVAIAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFD 308
+ IA K+KKT Q+++R+ ++ VI IPKS+ R+ ENIQ++DF L+ +E+ + SF+
Sbjct: 234 IKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFN 293
Query: 309 NGYRTLSPLFWAHSPYFPFESK 330
+R + L +H +PF+++
Sbjct: 294 RNWRACNVLQSSHLEDYPFDAE 315
>AF052577-1|AAC36465.1| 316|Homo sapiens aldo-keto reductase
protein.
Length = 316
Score = 224 bits (547), Expect = 4e-58
Identities = 121/322 (37%), Positives = 196/322 (60%), Gaps = 22/322 (6%)
Query: 24 LAPVLKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQ 83
+A ++L+ ++P G+GTW +V+++V+ AIDAGYRHID A +Y E +
Sbjct: 1 MATFVELSTKAKMPIVGLGTWKSPLG------KVKEAVKVAIDAGYRHIDCAYVYQNEHE 54
Query: 84 VGRAIKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPI 143
VG AI++KI E VKREDLF+ +KLW T ++ V A K+LK+L L Y+D+YLIHWP
Sbjct: 55 VGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQ 114
Query: 144 ALHD-----------NASISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEG 192
NA + +++ W+AM +++++GL K++GVSNF+ Q+E+L ++
Sbjct: 115 GFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKP 174
Query: 193 GV--TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFN--RQPSAPAPRADDQR 248
G+ P QVE + L Q L+ YC ++GI V AY+P G+ +P P+ +D +
Sbjct: 175 GLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPS-LLEDPK 233
Query: 249 LVAIAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFD 308
+ IA K+KKT Q+++R+ ++ VI IPKS+ R+ ENIQ++DF L+ +E+ + SF+
Sbjct: 234 IKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFN 293
Query: 309 NGYRTLSPLFWAHSPYFPFESK 330
+R + L +H +PF ++
Sbjct: 294 RNWRACNVLQSSHLEDYPFNAE 315
>AF524864-1|AAO13380.1| 316|Homo sapiens aldo-ketoreductase
protein.
Length = 316
Score = 223 bits (545), Expect = 7e-58
Identities = 120/322 (37%), Positives = 197/322 (61%), Gaps = 22/322 (6%)
Query: 24 LAPVLKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQ 83
+A ++L+ ++P G+GTW +V+++V+ AIDAGYRHID A +Y E +
Sbjct: 1 MATFVELSTKAKMPIVGLGTWKSPLG------KVKEAVKVAIDAGYRHIDCAYVYQNEHE 54
Query: 84 VGRAIKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPI 143
VG AI++KI E VKREDLF+ +KLW T ++ V A K+LK+ L Y+D+YLIHWP
Sbjct: 55 VGEAIQEKIQEKAVKREDLFIASKLWPTFFERPLVRKAFEKTLKDPKLSYLDVYLIHWPQ 114
Query: 144 ALHD-----------NASISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEG 192
NA + +++ W+AM +++++GL K++GVSNF+ Q+E+L ++
Sbjct: 115 GFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKP 174
Query: 193 GV--TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFN--RQPSAPAPRADDQR 248
G+ P QVE + L Q L+ YC ++GI V AY+P G+ +P P+ +D +
Sbjct: 175 GLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPS-LLEDPK 233
Query: 249 LVAIAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFD 308
+ IA K+KKT Q+++R+ ++ VI IPKS+ R+ ENIQ++DF L+ +E+ ++ SF+
Sbjct: 234 IKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMAIILSFN 293
Query: 309 NGYRTLSPLFWAHSPYFPFESK 330
+R + L +H +PF+++
Sbjct: 294 RNWRACNVLQSSHLEDYPFDAE 315
>M33375-1|AAA35658.1| 308|Homo sapiens protein ( Human chlordecone
reductase mRNA, complete cds. ).
Length = 308
Score = 223 bits (544), Expect = 9e-58
Identities = 126/311 (40%), Positives = 188/311 (60%), Gaps = 20/311 (6%)
Query: 36 IPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRAIKKKIAEG 95
+P G GT+ + EV K AI+AG+RHID+A +Y+ E+QVG AI+ KIA+G
Sbjct: 1 MPVLGFGTYAPPEVPRNRAVEVTKL---AIEAGFRHIDSAYLYNNEEQVGLAIRSKIADG 57
Query: 96 VVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL---------H 146
VKRED+F T+KLW T + + V PAL SLK L LDYVDLYL+H+P+AL
Sbjct: 58 SVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGETPLPKD 117
Query: 147 DNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV--TPSVLQVE 202
+N + D TW+ M + GL KSIGVSNFN +QLE + ++ G+ P QVE
Sbjct: 118 ENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVCNQVE 177
Query: 203 INLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVAIAQKYKKT 259
+ L Q LLD+CK++ IV+VA++ G ++ P++P +D L A+A+K+K+T
Sbjct: 178 CHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPV-LLEDPVLCALAKKHKRT 236
Query: 260 VPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGYRTLSPLFW 319
I LRY ++ GV+ + KS ++ R+ ENIQ+++F LT +++++L + YR + F
Sbjct: 237 PALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYVVMDFL 296
Query: 320 AHSPYFPFESK 330
P +PF +
Sbjct: 297 MDHPDYPFSDE 307
>AB209796-1|BAD93033.1| 260|Homo sapiens aldo-keto reductase family
1, member B1 variant protein.
Length = 260
Score = 194 bits (472), Expect = 5e-49
Identities = 106/251 (42%), Positives = 161/251 (64%), Gaps = 22/251 (8%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
L LNNG ++P G+GTW +V ++V+ AID GYRHID A +Y E++VG A
Sbjct: 2 LLLNNGAKMPILGLGTWKSPPG------QVTEAVKVAIDVGYRHIDCAHVYQNENEVGVA 55
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWP----- 142
I++K+ E VVKRE+LF+ +KLW T H+K V A +K+L +L LDY+DLYLIHWP
Sbjct: 56 IQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKP 115
Query: 143 ----IALHDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
L ++ ++ S T+ ++TW AM +++++GL K+IG+SNFN Q+E + ++ G+
Sbjct: 116 GKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKY 175
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFN--RQPSAPAPRADDQRLVAI 252
P+V Q+E + L Q L+ YC+++GIVV AY+P G+ +P P+ +D R+ AI
Sbjct: 176 KPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPS-LLEDPRIKAI 234
Query: 253 AQKYKKTVPQI 263
A K+ KT Q+
Sbjct: 235 AAKHNKTTAQV 245
>AB209017-1|BAD92254.1| 286|Homo sapiens aldo-keto reductase family
1, member C2 variant protein.
Length = 286
Score = 182 bits (444), Expect = 1e-45
Identities = 105/244 (43%), Positives = 152/244 (62%), Gaps = 20/244 (8%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+G +P G GT+ E+ + ++V+ AI+AG+ HID+A +Y+ E+QVG A
Sbjct: 21 VKLNDGHFMPVLGFGTYAPA---EVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLA 77
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL-- 145
I+ KIA+G VKRED+F T+KLW+ +H+ E V PAL +SLKNL LDYVDLYLIH+P+++
Sbjct: 78 IRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKP 137
Query: 146 -------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV-- 194
+N I D TW+AM + GL KSIGVSNFN + LE + ++ G+
Sbjct: 138 GEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKY 197
Query: 195 TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADDQRLVA 251
P QVE + Q LLD+CK++ IV+VAY+ G+ P++P +D L A
Sbjct: 198 KPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPV-LLEDPVLCA 256
Query: 252 IAQK 255
+A+K
Sbjct: 257 LAKK 260
>AL391427-2|CAI14727.1| 302|Homo sapiens aldo-keto reductase family
1, member C-like 1 protein.
Length = 302
Score = 177 bits (430), Expect = 6e-44
Identities = 111/309 (35%), Positives = 180/309 (58%), Gaps = 24/309 (7%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
++LN+G +P G GT+ ++ + + E K AID G+RHID+A +Y E++VG+A
Sbjct: 11 VRLNDGPFMPVLGFGTYAPDHTPKSQAAEATKV---AIDVGFRHIDSAYLYQNEEEVGQA 67
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIALHD 147
I +KIA+G VKRE++F T KLW T + E V PAL +SLK L DYVDL++IH P A+
Sbjct: 68 IWEKIADGTVKREEIFYTIKLWATFFRAELVHPALERSLKKLGPDYVDLFIIHVPFAMKQ 127
Query: 148 NASISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV--TPSVLQ-VEIN 204
D + + +++ + + +LE + ++ G+ P+ Q VE +
Sbjct: 128 PGK---------ELLPKDASGEIILETVELC--DTWELELILNKPGLRYKPTCNQVVECH 176
Query: 205 LNLQQPALLDYCKAQGIVVVAYTPFGNLFNRQ---PSAPAPRADDQRLVAIAQKYKKTVP 261
L Q LL++CK++ IV+VAY+ G+ + Q P P ++ L +IA+K+ ++
Sbjct: 177 PYLNQSKLLEFCKSKDIVLVAYSALGSQRDPQWVDPDCP-HLLEEPILKSIAKKHSRSPG 235
Query: 262 QIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGYRTLSPLFWAH 321
Q+ LRY ++ GV+ + KS ++R++EN QI+DF LTP++ +K+ D R L A+
Sbjct: 236 QVALRYQLQRGVVVLAKSFSQERIKENFQIFDFELTPED---MKAIDGLNRNLRYDNAAN 292
Query: 322 SPYFPFESK 330
PYFPF +
Sbjct: 293 HPYFPFSEE 301
>AL355303-1|CAI14201.1| 302|Homo sapiens aldo-keto reductase family
1, member C-like 1 protein.
Length = 302
Score = 177 bits (430), Expect = 6e-44
Identities = 111/309 (35%), Positives = 180/309 (58%), Gaps = 24/309 (7%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
++LN+G +P G GT+ ++ + + E K AID G+RHID+A +Y E++VG+A
Sbjct: 11 VRLNDGPFMPVLGFGTYAPDHTPKSQAAEATKV---AIDVGFRHIDSAYLYQNEEEVGQA 67
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIALHD 147
I +KIA+G VKRE++F T KLW T + E V PAL +SLK L DYVDL++IH P A+
Sbjct: 68 IWEKIADGTVKREEIFYTIKLWATFFRAELVHPALERSLKKLGPDYVDLFIIHVPFAMKQ 127
Query: 148 NASISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV--TPSVLQ-VEIN 204
D + + +++ + + +LE + ++ G+ P+ Q VE +
Sbjct: 128 PGK---------ELLPKDASGEIILETVELC--DTWELELILNKPGLRYKPTCNQVVECH 176
Query: 205 LNLQQPALLDYCKAQGIVVVAYTPFGNLFNRQ---PSAPAPRADDQRLVAIAQKYKKTVP 261
L Q LL++CK++ IV+VAY+ G+ + Q P P ++ L +IA+K+ ++
Sbjct: 177 PYLNQSKLLEFCKSKDIVLVAYSALGSQRDPQWVDPDCP-HLLEEPILKSIAKKHSRSPG 235
Query: 262 QIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGYRTLSPLFWAH 321
Q+ LRY ++ GV+ + KS ++R++EN QI+DF LTP++ +K+ D R L A+
Sbjct: 236 QVALRYQLQRGVVVLAKSFSQERIKENFQIFDFELTPED---MKAIDGLNRNLRYDNAAN 292
Query: 322 SPYFPFESK 330
PYFPF +
Sbjct: 293 HPYFPFSEE 301
>AL713867-3|CAI16410.1| 247|Homo sapiens aldo-keto reductase family
1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha
protein.
Length = 247
Score = 171 bits (415), Expect = 4e-42
Identities = 96/223 (43%), Positives = 140/223 (62%), Gaps = 17/223 (7%)
Query: 83 QVGRAIKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWP 142
+VG AI+ KIA+G VKRED+F T+KLW +H+ E V PAL +SLKNL LDYVDLYLIH+P
Sbjct: 26 EVGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFP 85
Query: 143 IAL---------HDNASI--SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSE 191
+++ +N I D TW+A+ + GL KSIGVSNFN +QLE + ++
Sbjct: 86 VSVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNK 145
Query: 192 GGV--TPSVLQVEINLNLQQPALLDYCKAQGIVVVAYTPFGNLFNR---QPSAPAPRADD 246
G+ P QVE + Q LLD+CK++ IV+VAY+ G+ P++P +D
Sbjct: 146 PGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPV-LLED 204
Query: 247 QRLVAIAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENI 289
L A+A+K+K+T I LRY ++ GV+ + KS ++ R+ +N+
Sbjct: 205 PVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNV 247
>AL355480-2|CAI22458.1| 147|Homo sapiens aldo-keto reductase family
1, member A1 (aldehydela) protein.
Length = 147
Score = 125 bits (302), Expect = 2e-28
Identities = 66/151 (43%), Positives = 94/151 (62%), Gaps = 18/151 (11%)
Query: 25 APVLKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQV 84
A + L+ G+++P G+GTW + + +V+ +V++A+ GYRHID AAIY E ++
Sbjct: 3 ASCVLLHTGQKMPLIGLGTW------KSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEI 56
Query: 85 GRAIKKKIAEG-VVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPI 143
G A+K+ + G V RE+LFVT+KLWNT H E V PALRK+L +L L+Y+DLYL+HWP
Sbjct: 57 GEALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPY 116
Query: 144 ALH--DN---------ASISQTDYVETWQAM 163
A DN T Y ETW+A+
Sbjct: 117 AFERGDNPFPKNADGTICYDSTHYKETWKAL 147
>AB037902-1|BAA92887.1| 130|Homo sapiens truncated aldo-keto
reductase protein.
Length = 130
Score = 116 bits (278), Expect = 2e-25
Identities = 57/123 (46%), Positives = 81/123 (65%), Gaps = 3/123 (2%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
+KLN+GK +P G GT + + ++ V+++V+ AID GYRHID+A + E+ +G+A
Sbjct: 9 VKLNDGKFMPILGFGTSV---ARKVAMSNVEEAVQVAIDVGYRHIDSAYTHLNEEGIGQA 65
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIALHD 147
I+KKIA G VKR+D+F TTK+W T + E V L SLK L L Y+DLYL H+P+ L
Sbjct: 66 IRKKIANGTVKRKDIFYTTKVWGTFSRPELVQRGLEMSLKKLQLSYMDLYLFHFPVPLQP 125
Query: 148 NAS 150
S
Sbjct: 126 GRS 128
>BC002862-1|AAH02862.1| 307|Homo sapiens AKR1CL2 protein protein.
Length = 307
Score = 115 bits (277), Expect = 2e-25
Identities = 57/109 (52%), Positives = 72/109 (66%), Gaps = 6/109 (5%)
Query: 35 EIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRAIKKKIAE 94
+IP G+ +W + +V ++V+ AIDAGYRH D A Y E +VG I+ KI E
Sbjct: 3 DIPAVGLSSWKASPG------KVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKE 56
Query: 95 GVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPI 143
G V+REDLF+ TKLW T HKK V A RKSLK L L+Y+DLYLIHWP+
Sbjct: 57 GAVRREDLFIATKLWCTCHKKSLVETACRKSLKALKLNYLDLYLIHWPM 105
Score = 109 bits (263), Expect = 1e-23
Identities = 58/163 (35%), Positives = 97/163 (59%), Gaps = 7/163 (4%)
Query: 152 SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV--TPSVLQVEINLNLQQ 209
S TD+++TW+AM D++ GL K+IGVSNFN +QLERL ++ G+ P Q+E + L Q
Sbjct: 144 SDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLRFKPLTNQIECHPYLTQ 203
Query: 210 PALLDYCKAQGIVVVAYTPFGNLFNRQPSAPAPRADDQRLVAIAQKYKKTVPQIVLRYLV 269
L+ +C+++ + V AY P G D+ + IA+++ K+ QI++R+ +
Sbjct: 204 KNLISFCQSRDVSVTAYRPLGG-----SCEGVDLIDNPVIKRIAKEHGKSPAQILIRFQI 258
Query: 270 ELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGYR 312
+ VI IP S+ ++ENIQ++DF LT ++ + S + R
Sbjct: 259 QRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLR 301
>AF263242-1|AAK58523.1| 320|Homo sapiens aldo-keto reductase
loopADR protein.
Length = 320
Score = 115 bits (277), Expect = 2e-25
Identities = 57/109 (52%), Positives = 72/109 (66%), Gaps = 6/109 (5%)
Query: 35 EIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRAIKKKIAE 94
+IP G+ +W + +V ++V+ AIDAGYRH D A Y E +VG I+ KI E
Sbjct: 3 DIPAVGLSSWKASPG------KVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKE 56
Query: 95 GVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPI 143
G V+REDLF+ TKLW T HKK V A RKSLK L L+Y+DLYLIHWP+
Sbjct: 57 GAVRREDLFIATKLWCTCHKKSLVETACRKSLKALKLNYLDLYLIHWPM 105
Score = 113 bits (271), Expect = 1e-24
Identities = 63/179 (35%), Positives = 105/179 (58%), Gaps = 9/179 (5%)
Query: 152 SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV--TPSVLQVEINLNLQQ 209
S TD+++TW+AM D++ GL K+IGVSNFN +QLERL ++ G+ P Q+E + L Q
Sbjct: 144 SDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLRFKPLTNQIECHPYLTQ 203
Query: 210 PALLDYCKAQGIVVVAYTPFGNLFNRQPSAPAPRADDQRLVAIAQKYKKTVPQIVLRYLV 269
L+ +C+++ + V AY P G D+ + IA+++ K+ QI++R+ +
Sbjct: 204 KNLISFCQSRDVSVTAYRPLGG-----SCEGVDLIDNPVIKRIAKEHGKSPAQILIRFQI 258
Query: 270 ELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGYR-TLSPLFWAHSPYFPF 327
+ VI IP S+ ++ENIQ++DF LT ++ + S + R + P+ H+ Y PF
Sbjct: 259 QRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMFPITKNHNDY-PF 316
>AB055603-1|BAC54568.1| 307|Homo sapiens aldo-keto reductase
related protein 4 protein.
Length = 307
Score = 115 bits (277), Expect = 2e-25
Identities = 57/109 (52%), Positives = 72/109 (66%), Gaps = 6/109 (5%)
Query: 35 EIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRAIKKKIAE 94
+IP G+ +W + +V ++V+ AIDAGYRH D A Y E +VG I+ KI E
Sbjct: 3 DIPAVGLSSWKASPG------KVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKE 56
Query: 95 GVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPI 143
G V+REDLF+ TKLW T HKK V A RKSLK L L+Y+DLYLIHWP+
Sbjct: 57 GAVRREDLFIATKLWCTCHKKSLVETACRKSLKALKLNYLDLYLIHWPM 105
Score = 109 bits (263), Expect = 1e-23
Identities = 58/163 (35%), Positives = 97/163 (59%), Gaps = 7/163 (4%)
Query: 152 SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV--TPSVLQVEINLNLQQ 209
S TD+++TW+AM D++ GL K+IGVSNFN +QLERL ++ G+ P Q+E + L Q
Sbjct: 144 SDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLRFKPLTNQIECHPYLTQ 203
Query: 210 PALLDYCKAQGIVVVAYTPFGNLFNRQPSAPAPRADDQRLVAIAQKYKKTVPQIVLRYLV 269
L+ +C+++ + V AY P G D+ + IA+++ K+ QI++R+ +
Sbjct: 204 KNLISFCQSRDVSVTAYRPLGG-----SCEGVDLIDNPVIKRIAKEHGKSPAQILIRFQI 258
Query: 270 ELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGYR 312
+ VI IP S+ ++ENIQ++DF LT ++ + S + R
Sbjct: 259 QRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLR 301
>AB040822-1|BAC54567.1| 222|Homo sapiens aldo-keto reductase
related protein 3 protein.
Length = 222
Score = 115 bits (277), Expect = 2e-25
Identities = 57/109 (52%), Positives = 72/109 (66%), Gaps = 6/109 (5%)
Query: 35 EIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRAIKKKIAE 94
+IP G+ +W + +V ++V+ AIDAGYRH D A Y E +VG I+ KI E
Sbjct: 3 DIPAVGLSSWKASPG------KVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKE 56
Query: 95 GVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPI 143
G V+REDLF+ TKLW T HKK V A RKSLK L L+Y+DLYLIHWP+
Sbjct: 57 GAVRREDLFIATKLWCTCHKKSLVETACRKSLKALKLNYLDLYLIHWPM 105
Score = 44.8 bits (101), Expect = 4e-04
Identities = 22/67 (32%), Positives = 39/67 (58%), Gaps = 2/67 (2%)
Query: 262 QIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGYR-TLSPLFWA 320
+I++R+ ++ VI IP S+ ++ENIQ++DF LT ++ + S + R + P+
Sbjct: 153 EILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMFPITKN 212
Query: 321 HSPYFPF 327
H Y PF
Sbjct: 213 HKDY-PF 218
>AB040821-1|BAC54566.1| 263|Homo sapiens aldo-keto reductase
related protein 2 protein.
Length = 263
Score = 115 bits (277), Expect = 2e-25
Identities = 57/109 (52%), Positives = 72/109 (66%), Gaps = 6/109 (5%)
Query: 35 EIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRAIKKKIAE 94
+IP G+ +W + +V ++V+ AIDAGYRH D A Y E +VG I+ KI E
Sbjct: 3 DIPAVGLSSWKASPG------KVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKE 56
Query: 95 GVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPI 143
G V+REDLF+ TKLW T HKK V A RKSLK L L+Y+DLYLIHWP+
Sbjct: 57 GAVRREDLFIATKLWCTCHKKSLVETACRKSLKALKLNYLDLYLIHWPM 105
Score = 58.8 bits (136), Expect = 2e-08
Identities = 28/64 (43%), Positives = 44/64 (68%), Gaps = 2/64 (3%)
Query: 152 SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV--TPSVLQVEINLNLQQ 209
S TD+++TW+AM D++ GL K+IGVSNFN +QLERL ++ G+ P Q+ I +Q+
Sbjct: 144 SDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLRFKPLTNQILIRFQIQR 203
Query: 210 PALL 213
++
Sbjct: 204 NVIV 207
Score = 48.4 bits (110), Expect = 3e-05
Identities = 24/74 (32%), Positives = 42/74 (56%), Gaps = 2/74 (2%)
Query: 255 KYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGYR-T 313
++K QI++R+ ++ VI IP S+ ++ENIQ++DF LT ++ + S + R
Sbjct: 187 RFKPLTNQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLA 246
Query: 314 LSPLFWAHSPYFPF 327
+ P+ H Y PF
Sbjct: 247 MFPITKNHKDY-PF 259
>AB040820-1|BAC54565.1| 250|Homo sapiens aldo-keto reductase
related protein 1 protein.
Length = 250
Score = 115 bits (277), Expect = 2e-25
Identities = 57/109 (52%), Positives = 72/109 (66%), Gaps = 6/109 (5%)
Query: 35 EIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRAIKKKIAE 94
+IP G+ +W + +V ++V+ AIDAGYRH D A Y E +VG I+ KI E
Sbjct: 3 DIPAVGLSSWKASPG------KVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKE 56
Query: 95 GVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPI 143
G V+REDLF+ TKLW T HKK V A RKSLK L L+Y+DLYLIHWP+
Sbjct: 57 GAVRREDLFIATKLWCTCHKKSLVETACRKSLKALKLNYLDLYLIHWPM 105
Score = 58.8 bits (136), Expect = 2e-08
Identities = 28/64 (43%), Positives = 44/64 (68%), Gaps = 2/64 (3%)
Query: 152 SQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV--TPSVLQVEINLNLQQ 209
S TD+++TW+AM D++ GL K+IGVSNFN +QLERL ++ G+ P Q+ I +Q+
Sbjct: 144 SDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLRFKPLTNQILIRFQIQR 203
Query: 210 PALL 213
++
Sbjct: 204 NVIV 207
Score = 45.6 bits (103), Expect = 2e-04
Identities = 19/58 (32%), Positives = 35/58 (60%)
Query: 255 KYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSFDNGYR 312
++K QI++R+ ++ VI IP S+ ++ENIQ++DF LT ++ + S + R
Sbjct: 187 RFKPLTNQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLR 244
>BC101205-1|AAI01206.1| 129|Homo sapiens aldo-keto reductase family
1, member C-like 1 protein.
Length = 129
Score = 113 bits (272), Expect = 8e-25
Identities = 56/118 (47%), Positives = 80/118 (67%), Gaps = 3/118 (2%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
++LN+G +P G GT+ ++ + + E K AID G+RHID+A +Y E++VG+A
Sbjct: 11 VRLNDGPFMPVLGFGTYAPDHTPKSQAAEATKV---AIDVGFRHIDSAYLYQNEEEVGQA 67
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL 145
I +KIA+G VKRE++F T KLW T + E V PAL +SLK L DYVDL++IH P A+
Sbjct: 68 IWEKIADGTVKREEIFYTIKLWATFFRAELVHPALERSLKKLGPDYVDLFIIHVPFAM 125
>BC101204-1|AAI01205.1| 129|Homo sapiens aldo-keto reductase family
1, member C-like 1 protein.
Length = 129
Score = 113 bits (272), Expect = 8e-25
Identities = 56/118 (47%), Positives = 80/118 (67%), Gaps = 3/118 (2%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
++LN+G +P G GT+ ++ + + E K AID G+RHID+A +Y E++VG+A
Sbjct: 11 VRLNDGPFMPVLGFGTYAPDHTPKSQAAEATKV---AIDVGFRHIDSAYLYQNEEEVGQA 67
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL 145
I +KIA+G VKRE++F T KLW T + E V PAL +SLK L DYVDL++IH P A+
Sbjct: 68 IWEKIADGTVKREEIFYTIKLWATFFRAELVHPALERSLKKLGPDYVDLFIIHVPFAM 125
>AK131335-1|BAD18494.1| 129|Homo sapiens protein ( Homo sapiens
cDNA FLJ16347 fis, clone TESTI2036288, moderately
similar to PROSTAGLANDIN-F SYNTHASE 1 (EC 1.1.1.188). ).
Length = 129
Score = 113 bits (272), Expect = 8e-25
Identities = 56/118 (47%), Positives = 80/118 (67%), Gaps = 3/118 (2%)
Query: 28 LKLNNGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRA 87
++LN+G +P G GT+ ++ + + E K AID G+RHID+A +Y E++VG+A
Sbjct: 11 VRLNDGPFMPVLGFGTYAPDHTPKSQAAEATKV---AIDVGFRHIDSAYLYQNEEEVGQA 67
Query: 88 IKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIAL 145
I +KIA+G VKRE++F T KLW T + E V PAL +SLK L DYVDL++IH P A+
Sbjct: 68 IWEKIADGTVKREEIFYTIKLWATFFRAELVHPALERSLKKLGPDYVDLFIIHVPFAM 125
>AF044961-1|AAC15671.1| 85|Homo sapiens aldose reductase-related
protein protein.
Length = 85
Score = 68.9 bits (161), Expect = 2e-11
Identities = 30/83 (36%), Positives = 55/83 (66%)
Query: 248 RLVAIAQKYKKTVPQIVLRYLVELGVIPIPKSLHKDRVEENIQIYDFSLTPDEIQLLKSF 307
++ IA K+KKT Q+++R+ ++ VI IPKS+ R+ ENIQ++DF L+ +E+ + SF
Sbjct: 2 KIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSF 61
Query: 308 DNGYRTLSPLFWAHSPYFPFESK 330
+ +R + L +H +PF+++
Sbjct: 62 NRNWRACNVLQSSHLEDYPFDAE 84
>AK058142-1|BAB71682.1| 146|Homo sapiens protein ( Homo sapiens
cDNA FLJ25413 fis, clone TST03402, highly similar to
3-OXO-5-BETA-STEROID 4-DEHYDROGENASE (EC 1.3.99.6). ).
Length = 146
Score = 64.9 bits (151), Expect = 4e-10
Identities = 34/78 (43%), Positives = 47/78 (60%), Gaps = 2/78 (2%)
Query: 159 TWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV--TPSVLQVEINLNLQQPALLDYC 216
TW+AM + GL KS+GVSNFN +QLE + ++ G+ P QVE + QP LL +C
Sbjct: 28 TWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKPVSNQVECHPYFTQPKLLKFC 87
Query: 217 KAQGIVVVAYTPFGNLFN 234
+ IV+ AY+P G N
Sbjct: 88 QQHDIVITAYSPLGTSRN 105
>U33429-1|AAC50955.1| 367|Homo sapiens K+ channel beta 2 subunit
protein.
Length = 367
Score = 57.2 bits (132), Expect = 8e-08
Identities = 47/164 (28%), Positives = 78/164 (47%), Gaps = 23/164 (14%)
Query: 32 NGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYST---EDQVGRAI 88
+G + G+GTW+ T ++ + ++ + A D G DTA +Y+ E +G I
Sbjct: 45 SGLRVSCLGLGTWV-TFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNII 103
Query: 89 KKKIAEGVVKREDLFVTTKL-WNTNHKKEA------VLPALRKSLKNLDLDYVDLYLIHW 141
KKK +R L +TTK+ W + E ++ L+ SL+ L L+YVD+ +
Sbjct: 104 KKK----GWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANR 159
Query: 142 PIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQL 185
P T ET +AMT V+NQG+ G S ++ ++
Sbjct: 160 PDP--------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEI 195
>CR542287-1|CAG47082.1| 353|Homo sapiens KCNAB2 protein.
Length = 353
Score = 57.2 bits (132), Expect = 8e-08
Identities = 47/164 (28%), Positives = 78/164 (47%), Gaps = 23/164 (14%)
Query: 32 NGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYST---EDQVGRAI 88
+G + G+GTW+ T ++ + ++ + A D G DTA +Y+ E +G I
Sbjct: 31 SGLRVSCLGLGTWV-TFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNII 89
Query: 89 KKKIAEGVVKREDLFVTTKL-WNTNHKKEA------VLPALRKSLKNLDLDYVDLYLIHW 141
KKK +R L +TTK+ W + E ++ L+ SL+ L L+YVD+ +
Sbjct: 90 KKK----GWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANR 145
Query: 142 PIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQL 185
P T ET +AMT V+NQG+ G S ++ ++
Sbjct: 146 PDP--------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEI 181
>BC130413-1|AAI30414.1| 367|Homo sapiens potassium voltage-gated
channel, shaker-related subfamily, beta member 2
protein.
Length = 367
Score = 57.2 bits (132), Expect = 8e-08
Identities = 47/164 (28%), Positives = 78/164 (47%), Gaps = 23/164 (14%)
Query: 32 NGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYST---EDQVGRAI 88
+G + G+GTW+ T ++ + ++ + A D G DTA +Y+ E +G I
Sbjct: 45 SGLRVSCLGLGTWV-TFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNII 103
Query: 89 KKKIAEGVVKREDLFVTTKL-WNTNHKKEA------VLPALRKSLKNLDLDYVDLYLIHW 141
KKK +R L +TTK+ W + E ++ L+ SL+ L L+YVD+ +
Sbjct: 104 KKK----GWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANR 159
Query: 142 PIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQL 185
P T ET +AMT V+NQG+ G S ++ ++
Sbjct: 160 PDP--------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEI 195
>BC126424-1|AAI26425.1| 367|Homo sapiens potassium voltage-gated
channel, shaker-related subfamily, beta member 2
protein.
Length = 367
Score = 57.2 bits (132), Expect = 8e-08
Identities = 47/164 (28%), Positives = 78/164 (47%), Gaps = 23/164 (14%)
Query: 32 NGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYST---EDQVGRAI 88
+G + G+GTW+ T ++ + ++ + A D G DTA +Y+ E +G I
Sbjct: 45 SGLRVSCLGLGTWV-TFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNII 103
Query: 89 KKKIAEGVVKREDLFVTTKL-WNTNHKKEA------VLPALRKSLKNLDLDYVDLYLIHW 141
KKK +R L +TTK+ W + E ++ L+ SL+ L L+YVD+ +
Sbjct: 104 KKK----GWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANR 159
Query: 142 PIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQL 185
P T ET +AMT V+NQG+ G S ++ ++
Sbjct: 160 PDP--------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEI 195
>BC110351-1|AAI10352.1| 395|Homo sapiens KCNAB2 protein protein.
Length = 395
Score = 57.2 bits (132), Expect = 8e-08
Identities = 47/164 (28%), Positives = 78/164 (47%), Gaps = 23/164 (14%)
Query: 32 NGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYST---EDQVGRAI 88
+G + G+GTW+ T ++ + ++ + A D G DTA +Y+ E +G I
Sbjct: 45 SGLRVSCLGLGTWV-TFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNII 103
Query: 89 KKKIAEGVVKREDLFVTTKL-WNTNHKKEA------VLPALRKSLKNLDLDYVDLYLIHW 141
KKK +R L +TTK+ W + E ++ L+ SL+ L L+YVD+ +
Sbjct: 104 KKK----GWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANR 159
Query: 142 PIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQL 185
P T ET +AMT V+NQG+ G S ++ ++
Sbjct: 160 PDP--------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEI 195
>AL035406-6|CAI19886.1| 253|Homo sapiens potassium voltage-gated
channel, shaker-related subfamily, beta member 2
protein.
Length = 253
Score = 57.2 bits (132), Expect = 8e-08
Identities = 47/164 (28%), Positives = 78/164 (47%), Gaps = 23/164 (14%)
Query: 32 NGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYST---EDQVGRAI 88
+G + G+GTW+ T ++ + ++ + A D G DTA +Y+ E +G I
Sbjct: 45 SGLRVSCLGLGTWV-TFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNII 103
Query: 89 KKKIAEGVVKREDLFVTTKL-WNTNHKKEA------VLPALRKSLKNLDLDYVDLYLIHW 141
KKK +R L +TTK+ W + E ++ L+ SL+ L L+YVD+ +
Sbjct: 104 KKK----GWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANR 159
Query: 142 PIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQL 185
P T ET +AMT V+NQG+ G S ++ ++
Sbjct: 160 PDP--------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEI 195
>AL035406-5|CAI19887.1| 254|Homo sapiens potassium voltage-gated
channel, shaker-related subfamily, beta member 2
protein.
Length = 254
Score = 57.2 bits (132), Expect = 8e-08
Identities = 47/164 (28%), Positives = 78/164 (47%), Gaps = 23/164 (14%)
Query: 32 NGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYST---EDQVGRAI 88
+G + G+GTW+ T ++ + ++ + A D G DTA +Y+ E +G I
Sbjct: 31 SGLRVSCLGLGTWV-TFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNII 89
Query: 89 KKKIAEGVVKREDLFVTTKL-WNTNHKKEA------VLPALRKSLKNLDLDYVDLYLIHW 141
KKK +R L +TTK+ W + E ++ L+ SL+ L L+YVD+ +
Sbjct: 90 KKK----GWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANR 145
Query: 142 PIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQL 185
P T ET +AMT V+NQG+ G S ++ ++
Sbjct: 146 PDP--------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEI 181
>AL035406-4|CAC08512.1| 367|Homo sapiens potassium voltage-gated
channel, shaker-related subfamily, beta member 2
protein.
Length = 367
Score = 57.2 bits (132), Expect = 8e-08
Identities = 47/164 (28%), Positives = 78/164 (47%), Gaps = 23/164 (14%)
Query: 32 NGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYST---EDQVGRAI 88
+G + G+GTW+ T ++ + ++ + A D G DTA +Y+ E +G I
Sbjct: 45 SGLRVSCLGLGTWV-TFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNII 103
Query: 89 KKKIAEGVVKREDLFVTTKL-WNTNHKKEA------VLPALRKSLKNLDLDYVDLYLIHW 141
KKK +R L +TTK+ W + E ++ L+ SL+ L L+YVD+ +
Sbjct: 104 KKK----GWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANR 159
Query: 142 PIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQL 185
P T ET +AMT V+NQG+ G S ++ ++
Sbjct: 160 PDP--------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEI 195
>AL035406-3|CAI19885.1| 353|Homo sapiens potassium voltage-gated
channel, shaker-related subfamily, beta member 2
protein.
Length = 353
Score = 57.2 bits (132), Expect = 8e-08
Identities = 47/164 (28%), Positives = 78/164 (47%), Gaps = 23/164 (14%)
Query: 32 NGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYST---EDQVGRAI 88
+G + G+GTW+ T ++ + ++ + A D G DTA +Y+ E +G I
Sbjct: 31 SGLRVSCLGLGTWV-TFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNII 89
Query: 89 KKKIAEGVVKREDLFVTTKL-WNTNHKKEA------VLPALRKSLKNLDLDYVDLYLIHW 141
KKK +R L +TTK+ W + E ++ L+ SL+ L L+YVD+ +
Sbjct: 90 KKK----GWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANR 145
Query: 142 PIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQL 185
P T ET +AMT V+NQG+ G S ++ ++
Sbjct: 146 PDP--------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEI 181
>AF044253-1|AAB99859.1| 353|Homo sapiens potassium channel beta 2
subunit protein.
Length = 353
Score = 57.2 bits (132), Expect = 8e-08
Identities = 47/164 (28%), Positives = 78/164 (47%), Gaps = 23/164 (14%)
Query: 32 NGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYST---EDQVGRAI 88
+G + G+GTW+ T ++ + ++ + A D G DTA +Y+ E +G I
Sbjct: 31 SGLRVSCLGLGTWV-TFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNII 89
Query: 89 KKKIAEGVVKREDLFVTTKL-WNTNHKKEA------VLPALRKSLKNLDLDYVDLYLIHW 141
KKK +R L +TTK+ W + E ++ L+ SL+ L L+YVD+ +
Sbjct: 90 KKK----GWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANR 145
Query: 142 PIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQL 185
P T ET +AMT V+NQG+ G S ++ ++
Sbjct: 146 PDP--------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEI 181
>AF029749-1|AAB84170.1| 367|Homo sapiens potassium channel beta 2
subunit protein.
Length = 367
Score = 57.2 bits (132), Expect = 8e-08
Identities = 47/164 (28%), Positives = 78/164 (47%), Gaps = 23/164 (14%)
Query: 32 NGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYST---EDQVGRAI 88
+G + G+GTW+ T ++ + ++ + A D G DTA +Y+ E +G I
Sbjct: 45 SGLRVSCLGLGTWV-TFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNII 103
Query: 89 KKKIAEGVVKREDLFVTTKL-WNTNHKKEA------VLPALRKSLKNLDLDYVDLYLIHW 141
KKK +R L +TTK+ W + E ++ L+ SL+ L L+YVD+ +
Sbjct: 104 KKK----GWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANR 159
Query: 142 PIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQL 185
P T ET +AMT V+NQG+ G S ++ ++
Sbjct: 160 PDP--------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEI 195
>X83127-1|CAA58208.1| 401|Homo sapiens voltage gated potassium
channels, beta subunit protein.
Length = 401
Score = 56.8 bits (131), Expect = 1e-07
Identities = 47/164 (28%), Positives = 79/164 (48%), Gaps = 23/164 (14%)
Query: 32 NGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYST---EDQVGRAI 88
+G + G+GTW+ T ++ + ++ + A ++G DTA +Y+ E +G I
Sbjct: 79 SGLRVSCLGLGTWV-TFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSII 137
Query: 89 KKKIAEGVVKREDLFVTTKL-WNTNHKKEA------VLPALRKSLKNLDLDYVDLYLIHW 141
KKK +R L +TTKL W + E ++ L+ SL+ L L+YVD+ +
Sbjct: 138 KKK----GWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANR 193
Query: 142 PIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQL 185
P S T E +AMT V+NQG+ G S ++ ++
Sbjct: 194 PD--------SNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEI 229
>U33428-1|AAC50953.1| 401|Homo sapiens K+ channel beta 1a subunit
protein.
Length = 401
Score = 56.8 bits (131), Expect = 1e-07
Identities = 47/164 (28%), Positives = 79/164 (48%), Gaps = 23/164 (14%)
Query: 32 NGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYST---EDQVGRAI 88
+G + G+GTW+ T ++ + ++ + A ++G DTA +Y+ E +G I
Sbjct: 79 SGLRVSCLGLGTWV-TFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSII 137
Query: 89 KKKIAEGVVKREDLFVTTKL-WNTNHKKEA------VLPALRKSLKNLDLDYVDLYLIHW 141
KKK +R L +TTKL W + E ++ L+ SL+ L L+YVD+ +
Sbjct: 138 KKK----GWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANR 193
Query: 142 PIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQL 185
P S T E +AMT V+NQG+ G S ++ ++
Sbjct: 194 PD--------SNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEI 229
>U16953-1|AAC50122.1| 408|Homo sapiens potassium channel beta3
subunit protein.
Length = 408
Score = 56.8 bits (131), Expect = 1e-07
Identities = 47/164 (28%), Positives = 79/164 (48%), Gaps = 23/164 (14%)
Query: 32 NGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYST---EDQVGRAI 88
+G + G+GTW+ T ++ + ++ + A ++G DTA +Y+ E +G I
Sbjct: 86 SGLRVSCLGLGTWV-TFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSII 144
Query: 89 KKKIAEGVVKREDLFVTTKL-WNTNHKKEA------VLPALRKSLKNLDLDYVDLYLIHW 141
KKK +R L +TTKL W + E ++ L+ SL+ L L+YVD+ +
Sbjct: 145 KKK----GWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANR 200
Query: 142 PIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQL 185
P S T E +AMT V+NQG+ G S ++ ++
Sbjct: 201 PD--------SNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEI 236
>L47665-1|AAC41926.1| 419|Homo sapiens K+ channel beta-subunit
protein.
Length = 419
Score = 56.8 bits (131), Expect = 1e-07
Identities = 47/164 (28%), Positives = 79/164 (48%), Gaps = 23/164 (14%)
Query: 32 NGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYST---EDQVGRAI 88
+G + G+GTW+ T ++ + ++ + A ++G DTA +Y+ E +G I
Sbjct: 97 SGLRVSCLGLGTWV-TFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSII 155
Query: 89 KKKIAEGVVKREDLFVTTKL-WNTNHKKEA------VLPALRKSLKNLDLDYVDLYLIHW 141
KKK +R L +TTKL W + E ++ L+ SL+ L L+YVD+ +
Sbjct: 156 KKK----GWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANR 211
Query: 142 PIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQL 185
P S T E +AMT V+NQG+ G S ++ ++
Sbjct: 212 PD--------SNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEI 247
>L39833-1|AAC37573.1| 408|Homo sapiens K+ channel beta-subunit
protein.
Length = 408
Score = 56.8 bits (131), Expect = 1e-07
Identities = 47/164 (28%), Positives = 79/164 (48%), Gaps = 23/164 (14%)
Query: 32 NGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYST---EDQVGRAI 88
+G + G+GTW+ T ++ + ++ + A ++G DTA +Y+ E +G I
Sbjct: 86 SGLRVSCLGLGTWV-TFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSII 144
Query: 89 KKKIAEGVVKREDLFVTTKL-WNTNHKKEA------VLPALRKSLKNLDLDYVDLYLIHW 141
KKK +R L +TTKL W + E ++ L+ SL+ L L+YVD+ +
Sbjct: 145 KKK----GWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANR 200
Query: 142 PIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQL 185
P S T E +AMT V+NQG+ G S ++ ++
Sbjct: 201 PD--------SNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEI 236
>BC043166-1|AAH43166.1| 401|Homo sapiens potassium voltage-gated
channel, shaker-related subfamily, beta member 1
protein.
Length = 401
Score = 56.8 bits (131), Expect = 1e-07
Identities = 47/164 (28%), Positives = 79/164 (48%), Gaps = 23/164 (14%)
Query: 32 NGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYST---EDQVGRAI 88
+G + G+GTW+ T ++ + ++ + A ++G DTA +Y+ E +G I
Sbjct: 79 SGLRVSCLGLGTWV-TFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSII 137
Query: 89 KKKIAEGVVKREDLFVTTKL-WNTNHKKEA------VLPALRKSLKNLDLDYVDLYLIHW 141
KKK +R L +TTKL W + E ++ L+ SL+ L L+YVD+ +
Sbjct: 138 KKK----GWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANR 193
Query: 142 PIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQL 185
P S T E +AMT V+NQG+ G S ++ ++
Sbjct: 194 PD--------SNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEI 229
>AK131252-1|BAD18431.1| 415|Homo sapiens protein ( Homo sapiens
cDNA FLJ16180 fis, clone BRHIP3000240, highly similar
to Homo sapiens potassium channel beta 2 subunit
(HKvbeta2.2) mRNA. ).
Length = 415
Score = 56.4 bits (130), Expect = 1e-07
Identities = 49/171 (28%), Positives = 84/171 (49%), Gaps = 22/171 (12%)
Query: 32 NGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYST---EDQVGRAI 88
+G + G+GTW+ T ++ + ++ + A D G DTA +Y+ E +G I
Sbjct: 78 SGLRVSCLGLGTWV-TFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNII 136
Query: 89 KKKIAEGVVKREDLFVTTKL-WNTNHKKEA------VLPALRKSLKNLDLDYVDLYLIHW 141
KKK +R L +TTK+ W + E ++ L+ SL+ L L+YVD+ +
Sbjct: 137 KKK----GWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANR 192
Query: 142 PIALHD------NASISQTDYVE-TWQAMTDVLNQGLTKSIGVSNFNIQQL 185
P ++S S+T +E T +AMT V+NQG+ G S ++ ++
Sbjct: 193 PDPNTPMEGDPFSSSKSRTFIIEETVRAMTHVINQGMAMYWGTSRWSSMEI 243
>CR542264-1|CAG47060.1| 353|Homo sapiens KCNAB2 protein.
Length = 353
Score = 54.8 bits (126), Expect = 4e-07
Identities = 46/164 (28%), Positives = 77/164 (46%), Gaps = 23/164 (14%)
Query: 32 NGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYST---EDQVGRAI 88
+G + G+GTW+ T ++ + ++ + A D G DTA +Y+ E +G I
Sbjct: 31 SGLRVSCLGLGTWV-TFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNII 89
Query: 89 KKKIAEGVVKREDLFVTTKL-WNTNHKKEA------VLPALRKSLKNLDLDYVDLYLIHW 141
KKK +R L +TTK+ W + E ++ L+ SL+ L+YVD+ +
Sbjct: 90 KKK----GWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERRQLEYVDVVFANR 145
Query: 142 PIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQL 185
P T ET +AMT V+NQG+ G S ++ ++
Sbjct: 146 PDP--------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEI 181
>BC099634-1|AAH99634.1| 404|Homo sapiens potassium voltage-gated
channel, shaker-related subfamily, beta member 3
protein.
Length = 404
Score = 47.6 bits (108), Expect = 6e-05
Identities = 41/161 (25%), Positives = 70/161 (43%), Gaps = 17/161 (10%)
Query: 32 NGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRAIKKK 91
+G + G+GTW+ T +++ + + + A + G DTA +Y+ + R +
Sbjct: 86 SGLRVSCLGLGTWV-TFGSQISDETAEDVLTVAYEHGVNLFDTAEVYAA-GKAERTLGNI 143
Query: 92 IAEGVVKREDLFVTTKL-WNTNHKKEA------VLPALRKSLKNLDLDYVDLYLIHWPIA 144
+ +R +TTK+ W + E ++ LR SL+ L L YVD+
Sbjct: 144 LKSKGWRRSSYVITTKIFWGGQAETERGLSRKHIIEGLRGSLERLQLGYVDIVFA----- 198
Query: 145 LHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQL 185
N S E +AMT V+NQGL G S + ++
Sbjct: 199 ---NRSDPNCPMEEIVRAMTYVINQGLALYWGTSRWGAAEI 236
>BC096234-1|AAH96234.1| 404|Homo sapiens potassium voltage-gated
channel, shaker-related subfamily, beta member 3
protein.
Length = 404
Score = 47.6 bits (108), Expect = 6e-05
Identities = 41/161 (25%), Positives = 70/161 (43%), Gaps = 17/161 (10%)
Query: 32 NGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRAIKKK 91
+G + G+GTW+ T +++ + + + A + G DTA +Y+ + R +
Sbjct: 86 SGLRVSCLGLGTWV-TFGSQISDETAEDVLTVAYEHGVNLFDTAEVYAA-GKAERTLGNI 143
Query: 92 IAEGVVKREDLFVTTKL-WNTNHKKEA------VLPALRKSLKNLDLDYVDLYLIHWPIA 144
+ +R +TTK+ W + E ++ LR SL+ L L YVD+
Sbjct: 144 LKSKGWRRSSYVITTKIFWGGQAETERGLSRKHIIEGLRGSLERLQLGYVDIVFA----- 198
Query: 145 LHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQL 185
N S E +AMT V+NQGL G S + ++
Sbjct: 199 ---NRSDPNCPMEEIVRAMTYVINQGLALYWGTSRWGAAEI 236
>BC096232-1|AAH96232.1| 404|Homo sapiens potassium voltage-gated
channel, shaker-related subfamily, beta member 3
protein.
Length = 404
Score = 47.6 bits (108), Expect = 6e-05
Identities = 41/161 (25%), Positives = 70/161 (43%), Gaps = 17/161 (10%)
Query: 32 NGKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRAIKKK 91
+G + G+GTW+ T +++ + + + A + G DTA +Y+ + R +
Sbjct: 86 SGLRVSCLGLGTWV-TFGSQISDETAEDVLTVAYEHGVNLFDTAEVYAA-GKAERTLGNI 143
Query: 92 IAEGVVKREDLFVTTKL-WNTNHKKEA------VLPALRKSLKNLDLDYVDLYLIHWPIA 144
+ +R +TTK+ W + E ++ LR SL+ L L YVD+
Sbjct: 144 LKSKGWRRSSYVITTKIFWGGQAETERGLSRKHIIEGLRGSLERLQLGYVDIVFA----- 198
Query: 145 LHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQL 185
N S E +AMT V+NQGL G S + ++
Sbjct: 199 ---NRSDPNCPMEEIVRAMTYVINQGLALYWGTSRWGAAEI 236
>AF016411-1|AAB92499.1| 404|Homo sapiens KCNA3.1B protein.
Length = 404
Score = 47.2 bits (107), Expect = 8e-05
Identities = 41/160 (25%), Positives = 69/160 (43%), Gaps = 17/160 (10%)
Query: 33 GKEIPGFGIGTWLGTNSNELKGDEVQKSVEWAIDAGYRHIDTAAIYSTEDQVGRAIKKKI 92
G + G+GTW+ T +++ + + + A + G DTA +Y+ + R + +
Sbjct: 87 GVRVSCLGLGTWV-TFGSQISDETAEDVLTVAYEHGVNLFDTAEVYAA-GKAERTLGNIL 144
Query: 93 AEGVVKREDLFVTTKL-WNTNHKKEA------VLPALRKSLKNLDLDYVDLYLIHWPIAL 145
+R +TTK+ W + E ++ LR SL+ L L YVD+
Sbjct: 145 KSKGWRRSSYVITTKIFWGGQAETERGLSRKHIIEGLRGSLERLQLGYVDIVFA------ 198
Query: 146 HDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNFNIQQL 185
N S E +AMT V+NQGL G S + ++
Sbjct: 199 --NRSDPNCPMEEIVRAMTYVINQGLALYWGTSRWGAAEI 236
>AB028065-1|BAA88489.1| 67|Homo sapiens prostaglandin F synthase
protein.
Length = 67
Score = 43.6 bits (98), Expect = 0.001
Identities = 20/40 (50%), Positives = 27/40 (67%)
Query: 155 DYVETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGV 194
D TW+AM + GL KSIGVSNFN +QLE + ++ G+
Sbjct: 20 DLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGL 59
>AB037905-2|BAA92890.1| 45|Homo sapiens truncated aldo-keto
reductase protein.
Length = 45
Score = 42.3 bits (95), Expect = 0.002
Identities = 19/43 (44%), Positives = 24/43 (55%)
Query: 108 LWNTNHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIALHDNAS 150
+W T + E V L SLK L L Y+DLYL H+P+ L S
Sbjct: 1 VWGTFSRPELVQRGLEMSLKKLQLSYMDLYLFHFPVPLQPGRS 43
>AF026947-1|AAC52104.1| 330|Homo sapiens aflatoxin aldehyde
reductase AFAR protein.
Length = 330
Score = 38.3 bits (85), Expect = 0.037
Identities = 46/174 (26%), Positives = 75/174 (43%), Gaps = 20/174 (11%)
Query: 65 IDAGYRHIDTAAIYSTEDQVGRAIKKKIAEGVVKRE-DLFVTTKL--WNTNH-KKEAVLP 120
++ G+ +DTA +YS D I + G+ + + + TK W+ K ++V
Sbjct: 35 LERGHTELDTAFMYS--DGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRS 92
Query: 121 ALRKSLKNLDLDYVDLYLIHWPIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNF 180
L SLK L VDL+ +H P D+ T ET A + +G +G+SN+
Sbjct: 93 QLETSLKRLQCPQVDLFYLHTP----DHG----TPVEETLHACQRLHQEGKFVELGLSNY 144
Query: 181 NIQQLERL----KSEGGVTPSVLQVEINLNLQQ--PALLDYCKAQGIVVVAYTP 228
++ + KS G + P+V Q N +Q L + G+ AY P
Sbjct: 145 ASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNP 198
>Y16675-1|CAA76347.1| 330|Homo sapiens aflatoxin B1-aldehyde
reductase protein.
Length = 330
Score = 37.9 bits (84), Expect = 0.049
Identities = 46/174 (26%), Positives = 75/174 (43%), Gaps = 20/174 (11%)
Query: 65 IDAGYRHIDTAAIYSTEDQVGRAIKKKIAEGVVKRE-DLFVTTKL--WNTNH-KKEAVLP 120
++ G+ +DTA +YS D I + G+ + + + TK W+ K ++V
Sbjct: 35 LERGHTELDTAFMYS--DGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRS 92
Query: 121 ALRKSLKNLDLDYVDLYLIHWPIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNF 180
L SLK L VDL+ +H P D+ T ET A + +G +G+SN+
Sbjct: 93 QLETSLKRLQCPQVDLFYLHAP----DHG----TPVEETLHACQRLHQEGKFVELGLSNY 144
Query: 181 NIQQLERL----KSEGGVTPSVLQVEINLNLQQ--PALLDYCKAQGIVVVAYTP 228
++ + KS G + P+V Q N +Q L + G+ AY P
Sbjct: 145 ASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNP 198
>BT007347-1|AAP36011.1| 330|Homo sapiens aldo-keto reductase family
7, member A2 (aflatoxin aldehyde reductase) protein.
Length = 330
Score = 37.9 bits (84), Expect = 0.049
Identities = 46/174 (26%), Positives = 75/174 (43%), Gaps = 20/174 (11%)
Query: 65 IDAGYRHIDTAAIYSTEDQVGRAIKKKIAEGVVKRE-DLFVTTKL--WNTNH-KKEAVLP 120
++ G+ +DTA +YS D I + G+ + + + TK W+ K ++V
Sbjct: 35 LERGHTELDTAFMYS--DGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRS 92
Query: 121 ALRKSLKNLDLDYVDLYLIHWPIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNF 180
L SLK L VDL+ +H P D+ T ET A + +G +G+SN+
Sbjct: 93 QLETSLKRLQCPQVDLFYLHAP----DHG----TPVEETLHACQRLHQEGKFVELGLSNY 144
Query: 181 NIQQLERL----KSEGGVTPSVLQVEINLNLQQ--PALLDYCKAQGIVVVAYTP 228
++ + KS G + P+V Q N +Q L + G+ AY P
Sbjct: 145 ASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNP 198
>BC013996-1|AAH13996.1| 330|Homo sapiens AKR7A2 protein protein.
Length = 330
Score = 37.9 bits (84), Expect = 0.049
Identities = 46/174 (26%), Positives = 75/174 (43%), Gaps = 20/174 (11%)
Query: 65 IDAGYRHIDTAAIYSTEDQVGRAIKKKIAEGVVKRE-DLFVTTKL--WNTNH-KKEAVLP 120
++ G+ +DTA +YS D I + G+ + + + TK W+ K ++V
Sbjct: 35 LERGHTELDTAFMYS--DGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRS 92
Query: 121 ALRKSLKNLDLDYVDLYLIHWPIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNF 180
L SLK L VDL+ +H P D+ T ET A + +G +G+SN+
Sbjct: 93 QLETSLKRLQCPQVDLFYLHAP----DHG----TPVEETLHACQRLHQEGKFVELGLSNY 144
Query: 181 NIQQLERL----KSEGGVTPSVLQVEINLNLQQ--PALLDYCKAQGIVVVAYTP 228
++ + KS G + P+V Q N +Q L + G+ AY P
Sbjct: 145 ASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNP 198
>BC012171-1|AAH12171.1| 330|Homo sapiens AKR7A2 protein protein.
Length = 330
Score = 37.9 bits (84), Expect = 0.049
Identities = 46/174 (26%), Positives = 75/174 (43%), Gaps = 20/174 (11%)
Query: 65 IDAGYRHIDTAAIYSTEDQVGRAIKKKIAEGVVKRE-DLFVTTKL--WNTNH-KKEAVLP 120
++ G+ +DTA +YS D I + G+ + + + TK W+ K ++V
Sbjct: 35 LERGHTELDTAFMYS--DGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRS 92
Query: 121 ALRKSLKNLDLDYVDLYLIHWPIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNF 180
L SLK L VDL+ +H P D+ T ET A + +G +G+SN+
Sbjct: 93 QLETSLKRLQCPQVDLFYLHAP----DHG----TPVEETLHACQRLHQEGKFVELGLSNY 144
Query: 181 NIQQLERL----KSEGGVTPSVLQVEINLNLQQ--PALLDYCKAQGIVVVAYTP 228
++ + KS G + P+V Q N +Q L + G+ AY P
Sbjct: 145 ASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNP 198
>BC011586-1|AAH11586.1| 330|Homo sapiens AKR7A2 protein protein.
Length = 330
Score = 37.9 bits (84), Expect = 0.049
Identities = 46/174 (26%), Positives = 75/174 (43%), Gaps = 20/174 (11%)
Query: 65 IDAGYRHIDTAAIYSTEDQVGRAIKKKIAEGVVKRE-DLFVTTKL--WNTNH-KKEAVLP 120
++ G+ +DTA +YS D I + G+ + + + TK W+ K ++V
Sbjct: 35 LERGHTELDTAFMYS--DGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRS 92
Query: 121 ALRKSLKNLDLDYVDLYLIHWPIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNF 180
L SLK L VDL+ +H P D+ T ET A + +G +G+SN+
Sbjct: 93 QLETSLKRLQCPQVDLFYLHAP----DHG----TPVEETLHACQRLHQEGKFVELGLSNY 144
Query: 181 NIQQLERL----KSEGGVTPSVLQVEINLNLQQ--PALLDYCKAQGIVVVAYTP 228
++ + KS G + P+V Q N +Q L + G+ AY P
Sbjct: 145 ASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNP 198
>BC010852-1|AAH10852.1| 330|Homo sapiens AKR7A2 protein protein.
Length = 330
Score = 37.9 bits (84), Expect = 0.049
Identities = 46/174 (26%), Positives = 75/174 (43%), Gaps = 20/174 (11%)
Query: 65 IDAGYRHIDTAAIYSTEDQVGRAIKKKIAEGVVKRE-DLFVTTKL--WNTNH-KKEAVLP 120
++ G+ +DTA +YS D I + G+ + + + TK W+ K ++V
Sbjct: 35 LERGHTELDTAFMYS--DGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRS 92
Query: 121 ALRKSLKNLDLDYVDLYLIHWPIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNF 180
L SLK L VDL+ +H P D+ T ET A + +G +G+SN+
Sbjct: 93 QLETSLKRLQCPQVDLFYLHAP----DHG----TPVEETLHACQRLHQEGKFVELGLSNY 144
Query: 181 NIQQLERL----KSEGGVTPSVLQVEINLNLQQ--PALLDYCKAQGIVVVAYTP 228
++ + KS G + P+V Q N +Q L + G+ AY P
Sbjct: 145 ASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNP 198
>BC007352-1|AAH07352.2| 358|Homo sapiens AKR7A2 protein protein.
Length = 358
Score = 37.9 bits (84), Expect = 0.049
Identities = 46/174 (26%), Positives = 75/174 (43%), Gaps = 20/174 (11%)
Query: 65 IDAGYRHIDTAAIYSTEDQVGRAIKKKIAEGVVKRE-DLFVTTKL--WNTNH-KKEAVLP 120
++ G+ +DTA +YS D I + G+ + + + TK W+ K ++V
Sbjct: 63 LERGHTELDTAFMYS--DGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRS 120
Query: 121 ALRKSLKNLDLDYVDLYLIHWPIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNF 180
L SLK L VDL+ +H P D+ T ET A + +G +G+SN+
Sbjct: 121 QLETSLKRLQCPQVDLFYLHAP----DHG----TPVEETLHACQRLHQEGKFVELGLSNY 172
Query: 181 NIQQLERL----KSEGGVTPSVLQVEINLNLQQ--PALLDYCKAQGIVVVAYTP 228
++ + KS G + P+V Q N +Q L + G+ AY P
Sbjct: 173 ASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNP 226
>BC004111-1|AAH04111.3| 330|Homo sapiens AKR7A2 protein protein.
Length = 330
Score = 37.9 bits (84), Expect = 0.049
Identities = 46/174 (26%), Positives = 75/174 (43%), Gaps = 20/174 (11%)
Query: 65 IDAGYRHIDTAAIYSTEDQVGRAIKKKIAEGVVKRE-DLFVTTKL--WNTNH-KKEAVLP 120
++ G+ +DTA +YS D I + G+ + + + TK W+ K ++V
Sbjct: 35 LERGHTELDTAFMYS--DGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRS 92
Query: 121 ALRKSLKNLDLDYVDLYLIHWPIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNF 180
L SLK L VDL+ +H P D+ T ET A + +G +G+SN+
Sbjct: 93 QLETSLKRLQCPQVDLFYLHAP----DHG----TPVEETLHACQRLHQEGKFVELGLSNY 144
Query: 181 NIQQLERL----KSEGGVTPSVLQVEINLNLQQ--PALLDYCKAQGIVVVAYTP 228
++ + KS G + P+V Q N +Q L + G+ AY P
Sbjct: 145 ASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNP 198
>AL035413-8|CAB72321.1| 330|Homo sapiens aldo-keto reductase family
7, member A2 (aflatoxin aldehyde reductase) protein.
Length = 330
Score = 37.9 bits (84), Expect = 0.049
Identities = 46/174 (26%), Positives = 75/174 (43%), Gaps = 20/174 (11%)
Query: 65 IDAGYRHIDTAAIYSTEDQVGRAIKKKIAEGVVKRE-DLFVTTKL--WNTNH-KKEAVLP 120
++ G+ +DTA +YS D I + G+ + + + TK W+ K ++V
Sbjct: 35 LERGHTELDTAFMYS--DGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRS 92
Query: 121 ALRKSLKNLDLDYVDLYLIHWPIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNF 180
L SLK L VDL+ +H P D+ T ET A + +G +G+SN+
Sbjct: 93 QLETSLKRLQCPQVDLFYLHAP----DHG----TPVEETLHACQRLHQEGKFVELGLSNY 144
Query: 181 NIQQLERL----KSEGGVTPSVLQVEINLNLQQ--PALLDYCKAQGIVVVAYTP 228
++ + KS G + P+V Q N +Q L + G+ AY P
Sbjct: 145 ASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNP 198
>BC042420-1|AAH42420.2| 331|Homo sapiens aldo-keto reductase family
7, member A3 (aflatoxin aldehyde reductase) protein.
Length = 331
Score = 37.1 bits (82), Expect = 0.086
Identities = 39/153 (25%), Positives = 70/153 (45%), Gaps = 18/153 (11%)
Query: 65 IDAGYRHIDTAAIYSTEDQV----GRAIKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLP 120
++ G+ IDTA +YS G ++ ++ VK + + L+ + K +++
Sbjct: 36 LERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAIP--LFGNSLKPDSLRF 93
Query: 121 ALRKSLKNLDLDYVDLYLIHWPIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNF 180
L SLK L VDL+ +H P D++ T ET +A + +G +G+SN+
Sbjct: 94 QLETSLKRLQCPRVDLFYLHMP----DHS----TPVEETLRACHQLHQEGKFMELGLSNY 145
Query: 181 NIQQLERL----KSEGGVTPSVLQVEINLNLQQ 209
++ + KS G + P+V Q N +Q
Sbjct: 146 AAWEVAEICTLCKSNGWILPTVYQGMYNAITRQ 178
>BC031562-1|AAH31562.1| 331|Homo sapiens aldo-keto reductase family
7, member A3 (aflatoxin aldehyde reductase) protein.
Length = 331
Score = 37.1 bits (82), Expect = 0.086
Identities = 39/153 (25%), Positives = 70/153 (45%), Gaps = 18/153 (11%)
Query: 65 IDAGYRHIDTAAIYSTEDQV----GRAIKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLP 120
++ G+ IDTA +YS G ++ ++ VK + + L+ + K +++
Sbjct: 36 LERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAIP--LFGNSLKPDSLRF 93
Query: 121 ALRKSLKNLDLDYVDLYLIHWPIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNF 180
L SLK L VDL+ +H P D++ T ET +A + +G +G+SN+
Sbjct: 94 QLETSLKRLQCPRVDLFYLHMP----DHS----TPVEETLRACHQLHQEGKFMELGLSNY 145
Query: 181 NIQQLERL----KSEGGVTPSVLQVEINLNLQQ 209
++ + KS G + P+V Q N +Q
Sbjct: 146 AAWEVAEICTLCKSNGWILPTVYQGMYNAITRQ 178
>AJ278012-1|CAC79668.1| 259|Homo sapiens aflatoxin B1 aldehyde
reductase 3 protein.
Length = 259
Score = 37.1 bits (82), Expect = 0.086
Identities = 33/121 (27%), Positives = 56/121 (46%), Gaps = 14/121 (11%)
Query: 114 KKEAVLPALRKSLKNLDLDYVDLYLIHWPIALHDNASISQTDYVETWQAMTDVLNQGLTK 173
K ++V L SLK L VDL+ +H P D+++ + ET +A + +G
Sbjct: 15 KPDSVRSQLETSLKRLQCPUVDLFYLHAP----DHSAPVE----ETLRACHQLHQEGKFV 66
Query: 174 SIGVSNFNIQQLERL----KSEGGVTPSVLQVEINLNLQQ--PALLDYCKAQGIVVVAYT 227
+G+SN+ ++ + KS G + P+V Q + +Q L Y + G+ AY
Sbjct: 67 ELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQVETELFPYLRHFGLRFYAYN 126
Query: 228 P 228
P
Sbjct: 127 P 127
>AJ271799-1|CAC81076.1| 331|Homo sapiens aflatoxin B1 aldehyde
reductase 2 protein.
Length = 331
Score = 37.1 bits (82), Expect = 0.086
Identities = 39/153 (25%), Positives = 70/153 (45%), Gaps = 18/153 (11%)
Query: 65 IDAGYRHIDTAAIYSTEDQV----GRAIKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLP 120
++ G+ IDTA +YS G ++ ++ VK + + L+ + K +++
Sbjct: 36 LERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAIP--LFGNSLKPDSLRF 93
Query: 121 ALRKSLKNLDLDYVDLYLIHWPIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNF 180
L SLK L VDL+ +H P D++ T ET +A + +G +G+SN+
Sbjct: 94 QLETSLKRLQCPRVDLFYLHMP----DHS----TPVEETLRACHQLHQEGKFMELGLSNY 145
Query: 181 NIQQLERL----KSEGGVTPSVLQVEINLNLQQ 209
++ + KS G + P+V Q N +Q
Sbjct: 146 AAWEVAEICTLCKSNGWILPTVYQGMYNAITRQ 178
>AF040639-1|AAD02195.1| 331|Homo sapiens aflatoxin B1-aldehyde
reductase protein.
Length = 331
Score = 37.1 bits (82), Expect = 0.086
Identities = 39/153 (25%), Positives = 70/153 (45%), Gaps = 18/153 (11%)
Query: 65 IDAGYRHIDTAAIYSTEDQV----GRAIKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLP 120
++ G+ IDTA +YS G ++ ++ VK + + L+ + K +++
Sbjct: 36 LERGHTEIDTAFVYSDGQSETILGGLGLRLGGSDCRVKIDTKAIP--LFGNSLKPDSLRF 93
Query: 121 ALRKSLKNLDLDYVDLYLIHWPIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNF 180
L SLK L VDL+ +H P D++ T ET +A + +G +G+SN+
Sbjct: 94 QLETSLKRLQCPRVDLFYLHMP----DHS----TPVEETLRACHQLHQEGKFMELGLSNY 145
Query: 181 NIQQLERL----KSEGGVTPSVLQVEINLNLQQ 209
++ + KS G + P+V Q N +Q
Sbjct: 146 AAWEVAEICTLCKSNGWILPTVYQGMYNAITRQ 178
>BC025709-1|AAH25709.1| 331|Homo sapiens aldo-keto reductase family
7, member A3 (aflatoxin aldehyde reductase) protein.
Length = 331
Score = 36.7 bits (81), Expect = 0.11
Identities = 39/153 (25%), Positives = 70/153 (45%), Gaps = 18/153 (11%)
Query: 65 IDAGYRHIDTAAIYSTEDQV----GRAIKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLP 120
++ G+ IDTA +YS G ++ ++ VK + + L+ + K +++
Sbjct: 36 LERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAIP--LFGNSLKPDSLRF 93
Query: 121 ALRKSLKNLDLDYVDLYLIHWPIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNF 180
L SLK L VDL+ +H P D++ T ET +A + +G +G+SN+
Sbjct: 94 QLETSLKRLQCPRVDLFYLHMP----DHS----TPVEETLRACHQLHQEGKFVELGLSNY 145
Query: 181 NIQQLERL----KSEGGVTPSVLQVEINLNLQQ 209
++ + KS G + P+V Q N +Q
Sbjct: 146 AAWEVAEICTLCKSNGWILPTVYQGMYNAITRQ 178
>AL035413-11|CAI22232.1| 331|Homo sapiens aldo-keto reductase
family 7, member A3 (aflatoxin aldehyde reductase)
protein.
Length = 331
Score = 36.7 bits (81), Expect = 0.11
Identities = 39/153 (25%), Positives = 70/153 (45%), Gaps = 18/153 (11%)
Query: 65 IDAGYRHIDTAAIYSTEDQV----GRAIKKKIAEGVVKREDLFVTTKLWNTNHKKEAVLP 120
++ G+ IDTA +YS G ++ ++ VK + + L+ + K +++
Sbjct: 36 LERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAIP--LFGNSLKPDSLRF 93
Query: 121 ALRKSLKNLDLDYVDLYLIHWPIALHDNASISQTDYVETWQAMTDVLNQGLTKSIGVSNF 180
L SLK L VDL+ +H P D++ T ET +A + +G +G+SN+
Sbjct: 94 QLETSLKRLQCPRVDLFYLHMP----DHS----TPVEETLRACHQLHQEGKFVELGLSNY 145
Query: 181 NIQQLERL----KSEGGVTPSVLQVEINLNLQQ 209
++ + KS G + P+V Q N +Q
Sbjct: 146 AAWEVAEICTLCKSNGWILPTVYQGMYNAITRQ 178
>L35546-1|AAA65028.1| 274|Homo sapiens gamma-glutamylcysteine
synthetase light subunit protein.
Length = 274
Score = 32.3 bits (70), Expect = 2.4
Identities = 28/131 (21%), Positives = 61/131 (46%), Gaps = 3/131 (2%)
Query: 98 KREDLFVTTKLWNT-NHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIALHDNASISQTDY 156
+RE++ V+ KL+ ++ + A+ + L + +D +I P + D ++S
Sbjct: 85 EREEMKVSAKLFIVESNSSSSTRSAVDMACSVLGVAQLDSVIIASP-PIEDGVNLSLEHL 143
Query: 157 VETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGVTPSVLQVEI-NLNLQQPALLDY 215
W+ + +++ +IG S+ + QLE+L V P+ QV + + + P L +
Sbjct: 144 QPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVMPPDLTAF 203
Query: 216 CKAQGIVVVAY 226
K I ++ +
Sbjct: 204 AKQFDIQLLTH 214
>CR541833-1|CAG46632.1| 274|Homo sapiens GCLM protein.
Length = 274
Score = 32.3 bits (70), Expect = 2.4
Identities = 28/131 (21%), Positives = 61/131 (46%), Gaps = 3/131 (2%)
Query: 98 KREDLFVTTKLWNT-NHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIALHDNASISQTDY 156
+RE++ V+ KL+ ++ + A+ + L + +D +I P + D ++S
Sbjct: 85 EREEMKVSAKLFIVESNSSSSTRSAVDMACSVLGVAQLDSVIIASP-PIEDGVNLSLEHL 143
Query: 157 VETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGVTPSVLQVEI-NLNLQQPALLDY 215
W+ + +++ +IG S+ + QLE+L V P+ QV + + + P L +
Sbjct: 144 QPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVMPPDLTAF 203
Query: 216 CKAQGIVVVAY 226
K I ++ +
Sbjct: 204 AKQFDIQLLTH 214
>BC041809-1|AAH41809.1| 274|Homo sapiens glutamate-cysteine ligase,
modifier subunit protein.
Length = 274
Score = 32.3 bits (70), Expect = 2.4
Identities = 28/131 (21%), Positives = 61/131 (46%), Gaps = 3/131 (2%)
Query: 98 KREDLFVTTKLWNT-NHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIALHDNASISQTDY 156
+RE++ V+ KL+ ++ + A+ + L + +D +I P + D ++S
Sbjct: 85 EREEMKVSAKLFIVESNSSSSTRSAVDMACSVLGVAQLDSVIIASP-PIEDGVNLSLEHL 143
Query: 157 VETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGVTPSVLQVEI-NLNLQQPALLDY 215
W+ + +++ +IG S+ + QLE+L V P+ QV + + + P L +
Sbjct: 144 QPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVMPPDLTAF 203
Query: 216 CKAQGIVVVAY 226
K I ++ +
Sbjct: 204 AKQFDIQLLTH 214
>AY773965-1|AAV28733.1| 274|Homo sapiens glutamate-cysteine ligase,
modifier subunit protein.
Length = 274
Score = 32.3 bits (70), Expect = 2.4
Identities = 28/131 (21%), Positives = 61/131 (46%), Gaps = 3/131 (2%)
Query: 98 KREDLFVTTKLWNT-NHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIALHDNASISQTDY 156
+RE++ V+ KL+ ++ + A+ + L + +D +I P + D ++S
Sbjct: 85 EREEMKVSAKLFIVESNSSSSTRSAVDMACSVLGVAQLDSVIIASP-PIEDGVNLSLEHL 143
Query: 157 VETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGVTPSVLQVEI-NLNLQQPALLDY 215
W+ + +++ +IG S+ + QLE+L V P+ QV + + + P L +
Sbjct: 144 QPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVMPPDLTAF 203
Query: 216 CKAQGIVVVAY 226
K I ++ +
Sbjct: 204 AKQFDIQLLTH 214
>AL117351-10|CAI22976.1| 274|Homo sapiens glutamate-cysteine
ligase, modifier subunit protein.
Length = 274
Score = 32.3 bits (70), Expect = 2.4
Identities = 28/131 (21%), Positives = 61/131 (46%), Gaps = 3/131 (2%)
Query: 98 KREDLFVTTKLWNT-NHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIALHDNASISQTDY 156
+RE++ V+ KL+ ++ + A+ + L + +D +I P + D ++S
Sbjct: 85 EREEMKVSAKLFIVESNSSSSTRSAVDMACSVLGVAQLDSVIIASP-PIEDGVNLSLEHL 143
Query: 157 VETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGVTPSVLQVEI-NLNLQQPALLDY 215
W+ + +++ +IG S+ + QLE+L V P+ QV + + + P L +
Sbjct: 144 QPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVMPPDLTAF 203
Query: 216 CKAQGIVVVAY 226
K I ++ +
Sbjct: 204 AKQFDIQLLTH 214
>AL049796-2|CAI21813.1| 274|Homo sapiens glutamate-cysteine ligase,
modifier subunit protein.
Length = 274
Score = 32.3 bits (70), Expect = 2.4
Identities = 28/131 (21%), Positives = 61/131 (46%), Gaps = 3/131 (2%)
Query: 98 KREDLFVTTKLWNT-NHKKEAVLPALRKSLKNLDLDYVDLYLIHWPIALHDNASISQTDY 156
+RE++ V+ KL+ ++ + A+ + L + +D +I P + D ++S
Sbjct: 85 EREEMKVSAKLFIVESNSSSSTRSAVDMACSVLGVAQLDSVIIASP-PIEDGVNLSLEHL 143
Query: 157 VETWQAMTDVLNQGLTKSIGVSNFNIQQLERLKSEGGVTPSVLQVEI-NLNLQQPALLDY 215
W+ + +++ +IG S+ + QLE+L V P+ QV + + + P L +
Sbjct: 144 QPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVMPPDLTAF 203
Query: 216 CKAQGIVVVAY 226
K I ++ +
Sbjct: 204 AKQFDIQLLTH 214
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.318 0.136 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 49,085,252
Number of Sequences: 224733
Number of extensions: 2058054
Number of successful extensions: 4116
Number of sequences better than 10.0: 140
Number of HSP's better than 10.0 without gapping: 94
Number of HSP's successfully gapped in prelim test: 46
Number of HSP's that attempted gapping in prelim test: 3671
Number of HSP's gapped (non-prelim): 151
length of query: 331
length of database: 73,234,838
effective HSP length: 90
effective length of query: 241
effective length of database: 53,008,868
effective search space: 12775137188
effective search space used: 12775137188
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
S2: 65 (30.3 bits)
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