Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001277-TA|BGIBMGA001277-PA|IPR001128|Cytochrome P450,
IPR002401|E-class P450, group I
(452 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
AK131190-1|BAD18388.1| 372|Homo sapiens .-.-). protein. 151 4e-36
BC039307-1|AAH39307.1| 372|Homo sapiens FLJ16008 protein protein. 151 7e-36
AY178622-1|AAO21126.1| 531|Homo sapiens steroid hydroxylase pro... 136 2e-31
M62401-1|AAA52142.1| 531|Homo sapiens sterol 27-hydroxylase pro... 135 3e-31
BC051851-1|AAH51851.1| 531|Homo sapiens cytochrome P450, family... 135 3e-31
BC040430-1|AAH40430.1| 531|Homo sapiens cytochrome P450, family... 135 3e-31
X59812-1|CAA42481.1| 530|Homo sapiens Vitamin D3 25-hydroxylase... 134 5e-31
AY288916-1|AAP31972.1| 508|Homo sapiens cytochrome P450, family... 134 8e-31
AF256213-1|AAG00416.1| 508|Homo sapiens 25- hydroxyvitamin D-1-... 134 8e-31
AF246895-1|AAF64299.1| 508|Homo sapiens 25-hydroxyvitamin D-1-a... 134 8e-31
AF027152-1|AAC51854.1| 508|Homo sapiens P450 25-hydroxyvitamin ... 134 8e-31
AF020192-1|AAC51853.1| 508|Homo sapiens 25-hydroxyvitamin D-1-a... 134 8e-31
AB006987-1|BAA23418.1| 508|Homo sapiens 25-hydroxyvitamin D3 1-... 134 8e-31
AB005990-1|BAA22657.1| 508|Homo sapiens 25-hydroxyvitamin D3 1a... 134 8e-31
AB005989-1|BAA22656.1| 508|Homo sapiens 25-hydroxyvitamin D3 1a... 134 8e-31
AB005038-1|BAA23416.1| 508|Homo sapiens 25-hydroxyvitamin D3 1-... 134 8e-31
X05367-1|CAA28965.1| 521|Homo sapiens desmolase protein. 121 5e-27
BC032329-1|AAH32329.1| 521|Homo sapiens cytochrome P450, family... 121 5e-27
M14565-1|AAA52162.1| 521|Homo sapiens CYP11A protein. 120 8e-27
L13286-1|AAA62379.1| 513|Homo sapiens 1,25-dihydroxyvitamin D3 ... 120 8e-27
AY858838-1|AAW50795.1| 372|Homo sapiens vitamin D 24-hydroxylas... 120 1e-26
AL138805-3|CAB91829.1| 514|Homo sapiens cytochrome P450, family... 120 1e-26
AL138805-1|CAM27342.1| 372|Homo sapiens cytochrome P450, family... 120 1e-26
D13752-1|BAA02899.1| 503|Homo sapiens steroid 18-hydroxylase pr... 115 4e-25
X54741-1|CAA38539.1| 503|Homo sapiens aldosterone synthase (P-... 113 2e-24
M32881-1|AAA35741.1| 503|Homo sapiens protein ( Human steroid 1... 110 9e-24
S67623-1|AAB29308.1| 257|Homo sapiens 25-hydroxyvitamin D 24-hy... 110 1e-23
X55764-1|CAA39290.1| 503|Homo sapiens protein ( Human mRNA for ... 109 3e-23
M32879-1|AAA52149.1| 503|Homo sapiens CYP11B1 protein. 109 3e-23
BC096287-1|AAH96287.1| 503|Homo sapiens cytochrome P450, family... 109 3e-23
BC096285-1|AAH96285.1| 574|Homo sapiens CYP11B1 protein protein. 109 3e-23
AF478474-1|AAL84813.1| 503|Homo sapiens mutated cytochrome P-45... 107 6e-23
AF233624-1|AAF99278.1| 534|Homo sapiens thromboxane synthase pr... 93 1e-18
M80647-1|AAA60618.1| 534|Homo sapiens thromboxane synthase prot... 93 2e-18
BC041157-1|AAH41157.1| 534|Homo sapiens thromboxane A synthase ... 93 2e-18
BC014117-1|AAH14117.1| 466|Homo sapiens TBXAS1 protein protein. 93 2e-18
AK223466-1|BAD97186.1| 534|Homo sapiens thromboxane A synthase ... 93 2e-18
AF233625-1|AAF99279.1| 534|Homo sapiens thromboxane synthase pr... 93 2e-18
AF233623-1|AAF99277.1| 534|Homo sapiens thromboxane synthase pr... 93 2e-18
AF233622-1|AAF99276.1| 534|Homo sapiens thromboxane synthase pr... 93 2e-18
AF233620-1|AAF99274.1| 534|Homo sapiens thromboxane synthase pr... 93 2e-18
AF233619-1|AAF99273.1| 534|Homo sapiens thromboxane synthase pr... 93 2e-18
AF233618-1|AAF99272.1| 534|Homo sapiens thromboxane synthase pr... 93 2e-18
AF233617-1|AAF99271.1| 534|Homo sapiens thromboxane synthase pr... 93 2e-18
AF233616-1|AAF99270.1| 534|Homo sapiens thromboxane synthase pr... 93 2e-18
AF233615-1|AAF99269.1| 534|Homo sapiens thromboxane synthase pr... 93 2e-18
M28253-1|AAA36404.1| 239|Homo sapiens cytochrome P-450-scc prot... 92 3e-18
AF233621-1|AAF99275.1| 534|Homo sapiens thromboxane synthase pr... 92 4e-18
BC060857-1|AAH60857.1| 525|Homo sapiens cytochrome P450, family... 91 6e-18
AY422002-1|AAR31180.1| 525|Homo sapiens cytochrome P450 4V2 pro... 91 6e-18
AK126473-1|BAC86562.1| 503|Homo sapiens protein ( Homo sapiens ... 91 6e-18
AK122600-1|BAC85487.1| 525|Homo sapiens protein ( Homo sapiens ... 91 6e-18
D34625-1|BAA07011.1| 533|Homo sapiens thromboxane synthase prot... 91 7e-18
BC028102-1|AAH28102.1| 509|Homo sapiens cytochrome P450, family... 88 7e-17
AY358537-1|AAQ88901.1| 509|Homo sapiens EFSW1929 protein. 88 7e-17
AM040940-1|CAJ13826.1| 509|Homo sapiens cytochrome P450 protein. 88 7e-17
AL450996-1|CAH71035.1| 509|Homo sapiens cytochrome P450, family... 88 7e-17
AK098065-1|BAC05226.1| 509|Homo sapiens protein ( Homo sapiens ... 88 7e-17
AK091806-1|BAC03751.1| 444|Homo sapiens protein ( Homo sapiens ... 88 7e-17
AK131355-1|BAD18508.1| 508|Homo sapiens protein ( Homo sapiens ... 87 9e-17
M18907-1|AAA35745.1| 503|Homo sapiens protein ( Human P450 mRNA... 86 2e-16
DQ924960-1|ABI96208.1| 503|Homo sapiens cytochrome P450 family ... 86 2e-16
DQ005611-1|AAY16980.1| 503|Homo sapiens cytochrome P450, family... 86 2e-16
BC101631-1|AAI01632.1| 503|Homo sapiens cytochrome P450, subfam... 86 2e-16
BC069418-1|AAH69418.1| 503|Homo sapiens cytochrome P450, family... 86 2e-16
AJ563377-1|CAD91345.1| 353|Homo sapiens cytochrome P450 protein. 86 2e-16
AJ563376-2|CAD91645.1| 430|Homo sapiens cytochrome P450 protein. 86 2e-16
AJ563375-1|CAD91343.1| 503|Homo sapiens cytochrome P450 protein. 86 2e-16
AF280107-2|AAG32290.1| 503|Homo sapiens cytochrome P450 polypep... 86 2e-16
AF209389-1|AAF21034.1| 503|Homo sapiens cytochrome P450 IIIA4 p... 86 2e-16
AF182273-1|AAF13598.1| 503|Homo sapiens cytochrome P450-3A4 pro... 86 2e-16
M24667-1|AAA52148.1| 256|Homo sapiens steroid 11-beta-hydroxyla... 85 6e-16
X12387-1|CAA30944.1| 503|Homo sapiens protein ( Human mRNA for ... 84 1e-15
M14096-1|AAA35744.1| 503|Homo sapiens protein ( Human cytochrom... 83 3e-15
J04449-1|AAA35747.1| 502|Homo sapiens cytochrome P450 nifedipin... 83 3e-15
M13785-1|AAA35742.1| 504|Homo sapiens protein ( Human liver glu... 82 3e-15
D00003-1|BAA00001.1| 504|Homo sapiens cytochrome P-450 protein. 82 3e-15
J04813-1|AAA02993.1| 502|Homo sapiens cytochrome P450 PCN3 prot... 81 6e-15
BC033862-1|AAH33862.1| 502|Homo sapiens cytochrome P450, family... 81 6e-15
AK223008-1|BAD96728.1| 502|Homo sapiens cytochrome P450, family... 81 6e-15
AC005020-1|AAS02016.1| 502|Homo sapiens unknown protein. 81 6e-15
BC132767-1|AAI32768.1| 544|Homo sapiens cytochrome P450, family... 81 1e-14
AY343323-1|AAQ21380.1| 544|Homo sapiens cytochrome P450 protein. 81 1e-14
AL358613-3|CAH72804.1| 428|Homo sapiens cytochrome P450, family... 80 2e-14
AL358613-2|CAH72803.1| 497|Homo sapiens cytochrome P450, family... 80 2e-14
AF005418-1|AAB88881.1| 497|Homo sapiens retinoic acid hydroxyla... 80 2e-14
Y07508-1|CAA68807.1| 503|Homo sapiens protein ( Human mRNA for ... 79 3e-14
X13589-1|CAA31929.1| 503|Homo sapiens protein ( Human mRNA for ... 79 3e-14
M30804-1|AAA35728.1| 503|Homo sapiens protein ( Human aromatase... 79 3e-14
M22246-1|AAA35557.1| 503|Homo sapiens protein ( Human aromatase... 79 3e-14
M18856-1|AAA35556.1| 419|Homo sapiens protein ( Human aromatase... 79 3e-14
D00408-1|BAA00310.1| 503|Homo sapiens cytochrome P-450 HFLa pro... 79 3e-14
DQ118405-1|AAZ23558.1| 503|Homo sapiens cytochrome P450 subfami... 79 3e-14
BC107785-1|AAI07786.1| 503|Homo sapiens cytochrome P450, family... 79 3e-14
BC067436-1|AAH67436.1| 503|Homo sapiens cytochrome P450, family... 79 3e-14
BC035959-1|AAH35959.1| 503|Homo sapiens cytochrome P450, family... 79 3e-14
AY957953-1|AAX44046.1| 503|Homo sapiens cytochrome P450, family... 79 3e-14
AF315325-1|AAG48618.1| 535|Homo sapiens cytochrome P450 variant... 79 3e-14
AF280107-3|AAG32289.1| 503|Homo sapiens cytochrome P450 polypep... 79 3e-14
AL358613-1|CAH72802.2| 522|Homo sapiens cytochrome P450, family... 77 1e-13
M28420-1|AAA52141.1| 419|Homo sapiens cytochrome P-450 aromatas... 76 3e-13
J04127-1|AAA52132.1| 503|Homo sapiens CYP19 protein. 76 3e-13
BC067429-1|AAH67429.1| 516|Homo sapiens cytochrome P450, family... 76 3e-13
AY390424-1|AAQ92352.1| 503|Homo sapiens cytochrome P450 CYP3A43... 76 3e-13
X58906-1|CAA41709.1| 495|Homo sapiens steroid 21-monooxygenase ... 75 4e-13
M28548-1|AAA52065.1| 495|Homo sapiens protein ( Human mutant 21... 75 4e-13
M26856-1|AAA52064.1| 495|Homo sapiens protein ( Human 21-hydrox... 75 4e-13
M13936-1|AAA59695.1| 494|Homo sapiens CYP21P protein. 75 4e-13
BX679671-8|CAM26071.1| 464|Homo sapiens cytochrome P450, family... 75 4e-13
BX679671-7|CAM26070.1| 494|Homo sapiens cytochrome P450, family... 75 4e-13
BC125182-1|AAI25183.1| 494|Homo sapiens cytochrome P450, family... 75 4e-13
BC125181-1|AAI25182.1| 495|Homo sapiens cytochrome P450, family... 75 4e-13
AM183951-1|CAJ75805.1| 494|Homo sapiens steroid 21-hydroxylase,... 75 4e-13
AM183949-1|CAJ75803.1| 494|Homo sapiens steroid 21-hydroxylase,... 75 4e-13
AM183947-1|CAJ75801.1| 494|Homo sapiens steroid 21-hydroxylase,... 75 4e-13
AM183946-1|CAJ75800.1| 494|Homo sapiens steroid 21-hydroxylase,... 75 4e-13
AM183945-1|CAJ75799.1| 494|Homo sapiens steroid 21-hydroxylase,... 75 4e-13
AM086565-1|CAJ31104.1| 494|Homo sapiens steroid 21-hydroxylase,... 75 4e-13
AM086564-1|CAJ31103.1| 494|Homo sapiens steroid 21-hydroxylase,... 75 4e-13
AL929593-2|CAI41778.1| 465|Homo sapiens cytochrome P450, family... 75 4e-13
AL929593-1|CAI41779.1| 495|Homo sapiens cytochrome P450, family... 75 4e-13
AL662849-19|CAI17480.1| 465|Homo sapiens cytochrome P450, famil... 75 4e-13
AL662849-18|CAI17479.1| 495|Homo sapiens cytochrome P450, famil... 75 4e-13
AL645922-24|CAI41754.1| 495|Homo sapiens cytochrome P450, famil... 75 4e-13
AL645922-23|CAI41755.1| 465|Homo sapiens cytochrome P450, famil... 75 4e-13
AL049547-7|CAB89301.1| 495|Homo sapiens dJ34F7.3 (cytochrome P4... 75 4e-13
AK054616-1|BAB70774.1| 465|Homo sapiens protein ( Homo sapiens ... 75 4e-13
AF077974-1|AAD45405.1| 403|Homo sapiens cytochrome P450 21-hydr... 75 4e-13
AF019413-2|AAB67982.1| 495|Homo sapiens cytochrome P450 21-hydr... 75 4e-13
M21550-1|AAA52063.1| 495|Homo sapiens CYP21 protein. 75 5e-13
BC100981-1|AAI00982.1| 393|Homo sapiens CYP3A43 protein protein. 75 5e-13
AY390425-1|AAQ92353.1| 503|Homo sapiens cytochrome P450 CYP3A43... 75 5e-13
AF337813-1|AAK38841.1| 503|Homo sapiens cytochrome P450 subfami... 75 5e-13
AF319634-1|AAK00325.1| 503|Homo sapiens cytochrome P450 CYP3A43... 75 5e-13
AF280108-1|AAG33009.1| 503|Homo sapiens cytochrome P450 subfami... 75 5e-13
AC011904-4|AAS07395.1| 503|Homo sapiens unknown protein. 75 5e-13
M33317-1|AAA52138.1| 494|Homo sapiens CYP2A protein. 75 7e-13
AY356349-1|AAQ55485.1| 522|Homo sapiens cytochrome P450 protein. 75 7e-13
BC117165-1|AAI17166.1| 494|Homo sapiens cytochrome P450, family... 74 9e-13
X02612-1|CAA26458.1| 512|Homo sapiens cytochrome P(1)-450 protein. 74 1e-12
X04300-1|CAA27843.1| 512|Homo sapiens P-450 c protein. 73 2e-12
EF094025-1|ABK41999.1| 512|Homo sapiens cytochrome P450, family... 73 2e-12
BC023019-1|AAH23019.1| 512|Homo sapiens cytochrome P450, family... 73 2e-12
AY310359-1|AAQ76692.1| 484|Homo sapiens cytochrome P450 1A1 var... 73 2e-12
AM236047-1|CAJ84704.1| 251|Homo sapiens cytochrome P450 1A1 pro... 73 2e-12
AM183948-1|CAJ75802.1| 494|Homo sapiens steroid 21-hydroxylase ... 73 2e-12
AK223113-1|BAD96833.1| 512|Homo sapiens cytochrome P450, family... 73 2e-12
AF280109-1|AAG33010.1| 504|Homo sapiens cytochrome P450 subfami... 73 2e-12
AF253322-1|AAK25727.1| 512|Homo sapiens cytochrome P450 protein. 73 2e-12
AC011904-5|AAS07394.1| 504|Homo sapiens unknown protein. 73 2e-12
K03191-1|AAA52139.1| 512|Homo sapiens CYP1A1 protein. 73 2e-12
Z00036-1|CAA77335.1| 515|Homo sapiens protein ( Human mRNA for ... 73 3e-12
X13930-1|CAA32118.1| 494|Homo sapiens protein ( Human CYP2A4 mR... 73 3e-12
X13929-1|CAA32117.1| 448|Homo sapiens P-450 IIA3 protein (1 is ... 73 3e-12
M55053-1|AAA52146.1| 515|Homo sapiens cytochrome P3-450 protein. 73 3e-12
M33318-1|AAA52067.1| 494|Homo sapiens CYP2A protein. 73 3e-12
M31667-1|AAA52163.1| 515|Homo sapiens CYP1A2 protein. 73 3e-12
M12079-1|AAA52152.1| 191|Homo sapiens POR protein. 73 3e-12
L00389-1|AAA35738.1| 516|Homo sapiens protein ( Human cytochrom... 73 3e-12
DQ022432-1|AAY26399.1| 516|Homo sapiens cytochrome P450, family... 73 3e-12
BC096256-1|AAH96256.1| 494|Homo sapiens cytochrome P450, family... 73 3e-12
BC096255-1|AAH96255.1| 494|Homo sapiens cytochrome P450, family... 73 3e-12
BC096254-1|AAH96254.1| 494|Homo sapiens cytochrome P450, family... 73 3e-12
BC096253-1|AAH96253.3| 494|Homo sapiens cytochrome P450, family... 73 3e-12
BC067428-1|AAH67428.1| 516|Homo sapiens cytochrome P450, family... 73 3e-12
BC067427-1|AAH67427.1| 516|Homo sapiens cytochrome P450, family... 73 3e-12
BC067426-1|AAH67426.1| 516|Homo sapiens cytochrome P450, family... 73 3e-12
BC067425-1|AAH67425.1| 516|Homo sapiens cytochrome P450, family... 73 3e-12
BC067424-1|AAH67424.1| 516|Homo sapiens cytochrome P450, family... 73 3e-12
AM183950-1|CAJ75804.1| 494|Homo sapiens steroid 21-hydroxylase,... 73 3e-12
AF253322-2|AAK25728.1| 516|Homo sapiens cytochrome P450 protein. 73 3e-12
AF182274-1|AAF13599.1| 516|Homo sapiens cytochrome P450-1A2 pro... 73 3e-12
U22027-1|AAB40518.1| 494|Homo sapiens cytochrome P450 protein. 71 6e-12
M12792-1|AAB59440.1| 494|Homo sapiens steroid 21-hydroxylase pr... 71 6e-12
AF182275-1|AAF13600.1| 494|Homo sapiens cytochrome P450-2A6 pro... 71 6e-12
X13897-1|CAA32097.1| 489|Homo sapiens protein ( Human mRNA for ... 71 8e-12
AK223108-1|BAD96828.1| 512|Homo sapiens cytochrome P450, family... 71 8e-12
L16876-1|AAA02630.1| 490|Homo sapiens cytochrome P-4502C18 prot... 71 1e-11
BC109084-1|AAI09085.1| 448|Homo sapiens CYP24A1 protein protein. 71 1e-11
BC109083-1|AAI09084.1| 448|Homo sapiens CYP24A1 protein protein. 71 1e-11
AL138805-2|CAM27343.1| 448|Homo sapiens cytochrome P450, family... 71 1e-11
X65962-1|CAA46778.1| 356|Homo sapiens cytochrome P-450 II C pro... 70 1e-11
U37143-1|AAC50370.2| 502|Homo sapiens cytochrome P450 monooxyge... 70 1e-11
M17252-1|AAA59985.1| 230|Homo sapiens CYP21 protein. 70 1e-11
BC067433-1|AAH67433.1| 493|Homo sapiens cytochrome P450, family... 70 1e-11
BC032594-1|AAH32594.1| 502|Homo sapiens cytochrome P450, family... 70 1e-11
AY426985-1|AAQ93356.1| 502|Homo sapiens cytochrome P450, family... 70 1e-11
AF272142-1|AAM44456.1| 502|Homo sapiens cytochrome P450 protein. 70 1e-11
M61856-1|AAB59356.1| 490|Homo sapiens cytochrome protein. 70 2e-11
BC096258-1|AAH96258.1| 490|Homo sapiens cytochrome P450, family... 70 2e-11
BC096257-1|AAH96257.1| 490|Homo sapiens cytochrome P450, family... 70 2e-11
BC069666-1|AAH69666.1| 490|Homo sapiens cytochrome P450, family... 70 2e-11
AL583836-1|CAH74067.1| 490|Homo sapiens cytochrome P450, family... 70 2e-11
AJ563378-3|CAD91347.1| 173|Homo sapiens hypothetical protein pr... 70 2e-11
AJ563378-2|CAD91647.1| 160|Homo sapiens cytochrome P450 protein. 70 2e-11
AF372573-1|AAL69652.1| 495|Homo sapiens cytochrome P450 2F1 pro... 70 2e-11
AB080265-1|BAB85489.1| 502|Homo sapiens cytochrome P450 2J2 pro... 70 2e-11
M63871-1|AAA59984.1| 508|Homo sapiens CYP17 protein. 69 3e-11
M61854-1|AAB59426.1| 490|Homo sapiens cytochrome protein. 69 3e-11
M31153-1|AAA52140.1| 508|Homo sapiens CYP17 protein. 69 3e-11
M19489-1|AAA36405.1| 508|Homo sapiens CYP17 protein. 69 3e-11
M14564-1|AAA52151.1| 508|Homo sapiens CYP17 protein. 69 3e-11
L39102-1|AAL31348.1| 217|Homo sapiens S-mephenytoin 4-hydroxyla... 69 3e-11
L07093-1|AAA36660.1| 468|Homo sapiens cytochrome P450 protein. 69 3e-11
J02906-1|AAA52156.1| 491|Homo sapiens CYP2F1 protein. 69 3e-11
DQ530598-1|ABF50972.1| 508|Homo sapiens cytochrome P450, family... 69 3e-11
BT020000-1|AAV38803.1| 508|Homo sapiens cytochrome P450, family... 69 3e-11
BC063388-1|AAH63388.1| 508|Homo sapiens cytochrome P450, family... 69 3e-11
BC062997-1|AAH62997.1| 508|Homo sapiens cytochrome P450, family... 69 3e-11
AY796203-1|AAV41877.1| 490|Homo sapiens cytochrome P450, family... 69 3e-11
AL583836-2|CAH74068.1| 490|Homo sapiens cytochrome P450, family... 69 3e-11
AL358790-3|CAI52498.1| 508|Homo sapiens cytochrome P450, family... 69 3e-11
AL133513-2|CAH73444.1| 490|Homo sapiens cytochrome P450, family... 69 3e-11
AK223510-1|BAD97230.1| 490|Homo sapiens cytochrome P450, family... 69 3e-11
M21939-1|AAA52158.1| 485|Homo sapiens CYP2C protein. 69 3e-11
M15331-1|AAA52157.1| 485|Homo sapiens CYP2C protein. 69 3e-11
J02843-1|AAA52155.1| 493|Homo sapiens protein ( Human cytochrom... 69 3e-11
J02625-1|AAA35743.1| 493|Homo sapiens protein ( Human cytochrom... 69 3e-11
DQ515958-1|ABF47105.1| 493|Homo sapiens cytochrome P450, family... 69 3e-11
DQ149222-1|AAZ77710.1| 493|Homo sapiens cytochrome P450 2E1 pro... 69 3e-11
AL161645-2|CAH70047.1| 493|Homo sapiens cytochrome P450, family... 69 3e-11
AF182276-1|AAF13601.1| 493|Homo sapiens cytochrome P450-2E1 pro... 69 3e-11
AF084225-1|AAD13753.1| 462|Homo sapiens cytochrome P450 2E1 pro... 69 3e-11
U22029-1|AAB40520.1| 494|Homo sapiens cytochrome P450 protein. 69 5e-11
M61858-1|AAA52145.1| 370|Homo sapiens CYP2C17 protein. 69 5e-11
BX538127-1|CAD98029.1| 310|Homo sapiens hypothetical protein pr... 69 5e-11
BC096260-1|AAH96260.1| 431|Homo sapiens CYP2C18 protein protein. 69 5e-11
Y00498-1|CAA68550.1| 490|Homo sapiens IIC2 protein. 68 8e-11
S46963-1|AAB23864.2| 477|Homo sapiens cytochrome P-450 protein. 68 8e-11
M21942-1|AAA52161.1| 462|Homo sapiens CYP2C protein. 68 8e-11
M21940-1|AAA52159.1| 383|Homo sapiens CYP2C protein. 68 8e-11
M17397-1|AAA35739.1| 490|Homo sapiens protein ( Human cytochrom... 68 8e-11
D00173-1|BAA00123.1| 487|Homo sapiens cytochrome P-450 protein. 68 8e-11
BC125054-1|AAI25055.1| 490|Homo sapiens cytochrome P450, family... 68 8e-11
BC067435-1|AAH67435.1| 493|Homo sapiens cytochrome P450, family... 68 8e-11
BC020596-1|AAH20596.1| 490|Homo sapiens cytochrome P450, family... 68 8e-11
AY702706-1|AAT94065.1| 490|Homo sapiens cytochrome P450, family... 68 8e-11
AY514490-1|AAR89907.1| 490|Homo sapiens cytochrome P450, family... 68 8e-11
AY341248-1|AAP88931.1| 490|Homo sapiens cytochrome P450, family... 68 8e-11
AL359672-5|CAH71307.1| 490|Homo sapiens cytochrome P450, family... 68 8e-11
AL359672-1|CAH71303.1| 490|Homo sapiens cytochrome P450, family... 68 8e-11
M21941-1|AAA52160.1| 480|Homo sapiens CYP2C protein. 67 1e-10
BC022539-1|AAH22539.1| 500|Homo sapiens cytochrome P450, family... 67 1e-10
AF094480-1|AAD41244.1| 500|Homo sapiens cholesterol 24-hydroxyl... 67 1e-10
X51535-1|CAA35915.1| 210|Homo sapiens cytochrome P-450 HPH (120... 66 2e-10
DQ282153-1|ABB77901.1| 497|Homo sapiens cytochrome P450 2D6 pro... 66 2e-10
BC067440-1|AAH67440.1| 520|Homo sapiens cytochrome P450, family... 66 2e-10
AY792513-1|AAV40834.1| 520|Homo sapiens cytochrome P450, family... 66 2e-10
AF054821-1|AAC08589.1| 520|Homo sapiens cytochrome P-450 protein. 66 2e-10
AB015306-1|BAA75823.1| 520|Homo sapiens Leukotriene B4 omega-hy... 66 2e-10
D26480-1|BAA05490.1| 520|Homo sapiens leukotriene B4 omega-hydr... 66 3e-10
BC067439-1|AAH67439.1| 520|Homo sapiens cytochrome P450, family... 66 3e-10
BC067437-1|AAH67437.1| 520|Homo sapiens cytochrome P450, family... 66 3e-10
AF467894-1|AAL67578.1| 520|Homo sapiens cytochrome P450, subfam... 66 3e-10
AC005336-1|AAC27730.1| 520|Homo sapiens CYP4F2 protein. 66 3e-10
X08006-1|CAA30807.1| 497|Homo sapiens cytochrome P450 db1 protein. 65 4e-10
M20403-1|AAA52153.1| 497|Homo sapiens CYP2D protein. 65 4e-10
D12620-1|BAA02144.1| 520|Homo sapiens cytochrome P-450LTBV prot... 65 4e-10
DQ282151-1|ABB77899.1| 496|Homo sapiens cytochrome P450 2D6 pro... 65 4e-10
BC104909-1|AAI04910.1| 501|Homo sapiens cytochrome P450, family... 65 4e-10
BC104907-1|AAI04908.1| 501|Homo sapiens cytochrome P450, family... 65 4e-10
AY323817-1|AAQ23114.1| 501|Homo sapiens cytochrome P450 2R1 pro... 65 4e-10
AB002461-1|BAA25991.1| 520|Homo sapiens leukotriene B4 omega-hy... 65 4e-10
AB002454-1|BAA25990.1| 520|Homo sapiens leukotriene B4 omega-hy... 65 4e-10
M33388-1|AAA53500.1| 497|Homo sapiens cytochrome P450 IID6 prot... 65 6e-10
M33189-1|AAA35737.1| 500|Homo sapiens protein ( Human debrisoqu... 65 6e-10
M24499-1|AAA36403.1| 373|Homo sapiens cytochrome P450db1 protein. 65 6e-10
M12078-1|AAA52154.1| 192|Homo sapiens POR protein. 65 6e-10
DQ282162-1|ABB77909.1| 500|Homo sapiens cytochrome P450 2D6 pro... 65 6e-10
DQ282160-1|ABB77908.1| 497|Homo sapiens cytochrome P450 2D6 pro... 65 6e-10
DQ282159-1|ABB77907.1| 497|Homo sapiens cytochrome P450 2D6 pro... 65 6e-10
DQ282158-1|ABB77906.1| 497|Homo sapiens cytochrome P450 2D6 pro... 65 6e-10
DQ282157-1|ABB77905.1| 497|Homo sapiens cytochrome P450 2D6 pro... 65 6e-10
DQ282156-1|ABB77904.1| 497|Homo sapiens cytochrome P450 2D6 pro... 65 6e-10
DQ282155-1|ABB77903.1| 497|Homo sapiens cytochrome P450 2D6 pro... 65 6e-10
DQ282154-1|ABB77902.1| 497|Homo sapiens cytochrome P450 2D6 pro... 65 6e-10
DQ282152-1|ABB77900.1| 497|Homo sapiens cytochrome P450 2D6 pro... 65 6e-10
DQ282147-1|ABB77898.1| 497|Homo sapiens cytochrome P450 2D6 pro... 65 6e-10
DQ282146-1|ABB77897.1| 497|Homo sapiens cytochrome P450 2D6 pro... 65 6e-10
DQ282145-1|ABB77896.1| 497|Homo sapiens cytochrome P450 2D6 pro... 65 6e-10
DQ282144-1|ABB77895.1| 497|Homo sapiens cytochrome P450 2D6 pro... 65 6e-10
DQ211354-2|ABB01372.1| 497|Homo sapiens cytochrome P450 2D6 pro... 65 6e-10
DQ211353-2|ABB01371.1| 497|Homo sapiens cytochrome P450 2D6 pro... 65 6e-10
DQ211353-1|ABB01370.1| 497|Homo sapiens cytochrome P450 2D6 pro... 65 6e-10
CR456430-1|CAG30316.1| 446|Homo sapiens CYP2D6 protein. 65 6e-10
BC126858-1|AAI26859.1| 497|Homo sapiens cytochrome P450, family... 65 6e-10
BC106758-1|AAI06759.1| 497|Homo sapiens cytochrome P450, family... 65 6e-10
BC106757-1|AAI06758.1| 446|Homo sapiens cytochrome P450, family... 65 6e-10
BC075024-1|AAH75024.1| 497|Homo sapiens cytochrome P450, family... 65 6e-10
BC075023-1|AAH75023.1| 497|Homo sapiens cytochrome P450, family... 65 6e-10
BC067432-1|AAH67432.1| 497|Homo sapiens cytochrome P450, family... 65 6e-10
BC066877-1|AAH66877.1| 446|Homo sapiens CYP2D6 protein protein. 65 6e-10
AY545216-1|AAS55001.1| 497|Homo sapiens cytochrome P4502D6 prot... 65 6e-10
AY358631-1|AAQ88994.1| 505|Homo sapiens EPSW3060 protein. 65 6e-10
AY262056-1|AAO89257.1| 505|Homo sapiens cytochrome P450 protein. 65 6e-10
AL450996-2|CAH71036.1| 505|Homo sapiens cytochrome P450, family... 65 6e-10
AL135960-6|CAI19734.1| 505|Homo sapiens cytochrome P450, family... 65 6e-10
AB209492-1|BAD92729.1| 566|Homo sapiens Debrisoquine 4-hydroxyl... 65 6e-10
U02388-1|AAC50052.2| 520|Homo sapiens cytochrome P450 4F2 protein. 64 7e-10
AY513609-1|AAR90940.1| 494|Homo sapiens cytochrome P450 2A13 va... 64 7e-10
AY513608-1|AAR90939.1| 494|Homo sapiens cytochrome P450 2A13 va... 64 7e-10
AY513606-1|AAR90937.1| 494|Homo sapiens cytochrome P450 2A13 va... 64 7e-10
AY513605-1|AAR90936.1| 494|Homo sapiens cytochrome P450 2A13 va... 64 7e-10
AY513604-1|AAR90935.1| 494|Homo sapiens cytochrome P450 2A13 va... 64 7e-10
AF209774-1|AAG35775.1| 494|Homo sapiens cytochrome P450 2A13 pr... 64 7e-10
S67581-1|AAB29503.1| 591|Homo sapiens fatty acid omega-hydroxyl... 64 1e-09
S67580-1|AAB29502.1| 519|Homo sapiens fatty acid omega-hydroxyl... 64 1e-09
BC109205-1|AAI09206.1| 512|Homo sapiens cytochrome P450, family... 64 1e-09
BC069443-1|AAH69443.1| 512|Homo sapiens cytochrome P450, family... 64 1e-09
AF252297-1|AAF76003.1| 512|Homo sapiens cytochrome P450 retinoi... 64 1e-09
AC007002-1|AAY14690.1| 512|Homo sapiens unknown protein. 64 1e-09
BC096286-1|AAH96286.1| 437|Homo sapiens cytochrome P450, family... 64 1e-09
AF133298-1|AAD49566.1| 520|Homo sapiens cytochrome P450 protein. 64 1e-09
AF525488-1|AAO16078.1| 519|Homo sapiens cytochrome P450, subfam... 63 2e-09
L04751-1|AAA58436.1| 519|Homo sapiens cytochrome P450 protein. 63 2e-09
D26481-1|BAA05491.1| 519|Homo sapiens fatty acids omega-hydroxy... 63 2e-09
AY369778-1|AAQ56847.1| 519|Homo sapiens cytochrome P450, family... 63 2e-09
AL731892-3|CAH72778.1| 519|Homo sapiens cytochrome P450, family... 63 2e-09
M80646-1|AAA60617.1| 460|Homo sapiens thromboxane synthase prot... 62 4e-09
BC033691-1|AAH33691.1| 504|Homo sapiens cytochrome P450, family... 62 5e-09
BC016853-1|AAH16853.1| 524|Homo sapiens CYP4F11 protein protein. 62 5e-09
AY358603-1|AAQ88966.1| 504|Homo sapiens Cytochrome p450 protein. 62 5e-09
AK027605-1|BAB55227.1| 564|Homo sapiens protein ( Homo sapiens ... 62 5e-09
AF335278-1|AAK13498.1| 504|Homo sapiens cytochrome P450 2S1 pro... 62 5e-09
AF236085-1|AAG15889.1| 524|Homo sapiens CYP4F11 protein. 62 5e-09
U22028-1|AAB40519.1| 494|Homo sapiens cytochrome P450 protein. 61 7e-09
D13705-1|BAA02864.1| 521|Homo sapiens fatty acid omega-hydroxyl... 60 2e-08
BC035350-1|AAH35350.1| 524|Homo sapiens cytochrome P450, family... 60 2e-08
AY358977-1|AAQ89336.1| 524|Homo sapiens CYP4F12 protein. 60 2e-08
AY280372-1|AAQ21368.1| 519|Homo sapiens cytochrome P450 4A22 pr... 60 2e-08
AY008841-1|AAG33247.1| 524|Homo sapiens cytochrome P450 isoform... 60 2e-08
AC004523-1|AAC11543.1| 458|Homo sapiens F22329_1 protein. 60 2e-08
AB035131-1|BAB18270.1| 524|Homo sapiens cytochrome P450 protein. 60 2e-08
AB035130-1|BAB18269.1| 524|Homo sapiens cytochrome P450 protein. 60 2e-08
BC093896-1|AAH93896.1| 531|Homo sapiens cytochrome P450, family... 59 3e-08
BC093894-1|AAH93894.1| 531|Homo sapiens cytochrome P450, family... 59 3e-08
BC069351-1|AAH69351.1| 531|Homo sapiens cytochrome P450, family... 59 3e-08
AY280371-1|AAQ21367.1| 519|Homo sapiens cytochrome P450 4A22K p... 59 3e-08
AK096820-1|BAC04868.1| 531|Homo sapiens protein ( Homo sapiens ... 59 3e-08
X16699-1|CAA34672.1| 511|Homo sapiens protein ( Human mRNA for ... 58 6e-08
J02871-1|AAA35712.1| 511|Homo sapiens protein ( Human lung cyto... 58 6e-08
DQ518907-1|ABF47106.1| 511|Homo sapiens cytochrome P450, family... 58 6e-08
BC017758-1|AAH17758.1| 512|Homo sapiens cytochrome P450, family... 58 6e-08
AY151049-1|AAN72312.1| 497|Homo sapiens pulmonary cytochrome P4... 58 6e-08
AY151048-1|AAN72311.1| 512|Homo sapiens pulmonary cytochrome P4... 58 6e-08
AY064485-1|AAL57720.1| 511|Homo sapiens cytochrome P450 protein. 58 6e-08
AL593856-7|CAI16983.1| 497|Homo sapiens cytochrome P450, family... 58 6e-08
AL593856-6|CAI16982.1| 512|Homo sapiens cytochrome P450, family... 58 6e-08
AL593856-5|CAI16981.1| 511|Homo sapiens cytochrome P450, family... 58 6e-08
AL356793-4|CAI22559.1| 511|Homo sapiens cytochrome P450, family... 58 6e-08
AL356793-3|CAI22557.1| 512|Homo sapiens cytochrome P450, family... 58 6e-08
AL356793-2|CAI22558.1| 497|Homo sapiens cytochrome P450, family... 58 6e-08
AF491285-1|AAM09532.1| 511|Homo sapiens cytochrome P450 protein. 58 6e-08
BC032322-1|AAH32322.1| 509|Homo sapiens cytochrome P450, family... 58 8e-08
BC025761-1|AAH25761.2| 490|Homo sapiens cytochrome P450, family... 58 8e-08
AY064486-1|AAL57721.1| 511|Homo sapiens cytochrome P450 protein. 58 8e-08
U23942-1|AAB39951.1| 509|Homo sapiens lanosterol 14-demethylase... 57 1e-07
D55653-1|BAA09512.1| 509|Homo sapiens lanosterol 14-demethylase... 57 1e-07
AM233517-1|CAJ80720.1| 175|Homo sapiens cytochrome P450 1A1 pro... 57 1e-07
AC000120-2|AAB46356.1| 509|Homo sapiens unknown protein. 57 1e-07
U51692-1|AAC50951.1| 503|Homo sapiens lanosterol 14-alpha demet... 56 3e-07
AL135960-10|CAI19737.1| 519|Homo sapiens cytochrome P450, famil... 56 3e-07
AF208532-1|AAF76722.1| 519|Homo sapiens fatty acid omega-hydrox... 56 3e-07
U03688-1|AAA19567.1| 543|Homo sapiens cytochrome P450 protein. 55 4e-07
L16883-1|AAD13467.1| 169|Homo sapiens cytochrome P-450 2C protein. 55 4e-07
BT020001-1|AAV38804.1| 543|Homo sapiens cytochrome P450, family... 55 4e-07
BC012049-1|AAH12049.1| 543|Homo sapiens cytochrome P450, family... 55 4e-07
AC009229-2|AAY15039.1| 543|Homo sapiens unknown protein. 55 4e-07
U56438-1|AAC50809.1| 543|Homo sapiens dioxin-inducible cytochro... 55 6e-07
BT019979-1|AAV38782.1| 543|Homo sapiens cytochrome P450, family... 55 6e-07
AY393998-1|AAQ87875.1| 543|Homo sapiens cytochrome P450, family... 55 6e-07
AF450132-1|AAM50512.1| 543|Homo sapiens cytochrome P450 CYP1B1 ... 55 6e-07
BC100982-1|AAI00983.1| 280|Homo sapiens CYP3A43 protein protein. 54 8e-07
AF280110-1|AAG33011.1| 420|Homo sapiens cytochrome P450 subfami... 54 8e-07
AY220845-1|AAO49806.1| 516|Homo sapiens cytochrome P450 protein. 54 1e-06
AB209700-1|BAD92937.1| 336|Homo sapiens cytochrome P450, family... 54 1e-06
AK127234-1|BAC86895.1| 130|Homo sapiens ). protein. 54 1e-06
K03192-1|AAA52147.1| 331|Homo sapiens CYP1A1 protein. 53 2e-06
X71480-1|CAA50586.1| 141|Homo sapiens cytochrome P450 protein. 53 2e-06
S77409-1|AAB34643.1| 228|Homo sapiens steroid 18-hydroxylase pr... 53 2e-06
AK090886-1|BAC03539.1| 337|Homo sapiens protein ( Homo sapiens ... 53 2e-06
M29874-1|AAA52144.1| 491|Homo sapiens CYP2B protein. 52 4e-06
DQ298753-1|ABB84469.1| 491|Homo sapiens cytochrome P450, family... 52 4e-06
BC067431-1|AAH67431.1| 491|Homo sapiens cytochrome P450, family... 52 4e-06
BC067430-1|AAH67430.1| 491|Homo sapiens cytochrome P450, family... 52 4e-06
AF182277-1|AAF13602.1| 491|Homo sapiens cytochrome P450-2B6 pro... 52 4e-06
AC023172-1|AAF32444.1| 491|Homo sapiens CYP2B6 protein. 52 4e-06
BC128535-1|AAI28536.1| 143|Homo sapiens LOC283480 protein protein. 50 2e-05
AY871801-1|AAX62803.1| 483|Homo sapiens cytochrome P450 family ... 49 3e-05
BC041158-1|AAH41158.1| 455|Homo sapiens CYP4A11 protein protein. 49 4e-05
AL731892-4|CAH72779.1| 455|Homo sapiens cytochrome P450, family... 49 4e-05
AK127151-1|BAC86855.1| 146|Homo sapiens protein ( Homo sapiens ... 48 5e-05
DQ016495-1|AAY34975.1| 195|Homo sapiens cytochrome P450 1B1 pro... 48 9e-05
BC010358-1|AAH10358.1| 469|Homo sapiens cytochrome P450, family... 48 9e-05
AL591242-1|CAH73899.1| 469|Homo sapiens cytochrome P450, family... 48 9e-05
AL035670-1|CAI20276.1| 469|Homo sapiens cytochrome P450, family... 48 9e-05
AF237982-1|AAF63329.1| 469|Homo sapiens oxysterol 7alpha-hydrox... 47 1e-04
L36085-1|AAC01761.1| 441|Homo sapiens thromboxane A2 synthase p... 46 2e-04
X56088-1|CAA39568.1| 504|Homo sapiens cholesterol 7-alpha-hydr... 45 5e-04
M93133-1|AAA58435.1| 504|Homo sapiens cholesterol 7-alpha hydro... 44 8e-04
BC112184-1|AAI12185.1| 504|Homo sapiens cytochrome P450, family... 44 8e-04
BC101777-1|AAI01778.1| 504|Homo sapiens cytochrome P450, family... 44 8e-04
AL135960-11|CAI19738.1| 455|Homo sapiens cytochrome P450, famil... 44 8e-04
AM233518-1|CAJ80721.1| 157|Homo sapiens cytochrome P450 1A1 pro... 44 0.001
AJ877238-1|CAI47002.1| 97|Homo sapiens putative cytochrome P45... 44 0.001
AF040259-1|AAD10199.1| 144|Homo sapiens cytochrome P450 1A1 pro... 44 0.001
BC096259-1|AAH96259.1| 443|Homo sapiens CYP2C18 protein protein. 43 0.002
AL135960-9|CAI19736.1| 421|Homo sapiens cytochrome P450, family... 43 0.003
AJ563379-2|CAD91649.1| 84|Homo sapiens cytochrome P450 protein. 40 0.014
BC056258-1|AAH56258.1| 359|Homo sapiens CYP19A1 protein protein. 40 0.018
BC020767-1|AAH20767.1| 360|Homo sapiens Unknown (protein for IM... 40 0.018
AF176805-1|AAK11850.1| 506|Homo sapiens oxysterol 7alpha-hydrox... 40 0.024
AF127090-1|AAD20021.1| 506|Homo sapiens oxysterol 7alpha-hydrox... 40 0.024
AF029403-1|AAC95426.1| 506|Homo sapiens oxysterol 7alpha-hydrox... 40 0.024
X58904-1|CAA41707.1| 371|Homo sapiens steroid 21-monooxygenase ... 38 0.073
X58902-1|CAA41706.1| 372|Homo sapiens steroid 21-monooxygenase ... 38 0.073
X58900-1|CAA41704.1| 372|Homo sapiens steroid 21-monooxygenase ... 38 0.073
X58899-1|CAA41703.1| 368|Homo sapiens steroid 21-monooxygenase ... 38 0.073
X58898-1|CAA41702.1| 371|Homo sapiens steroid 21-monooxygenase ... 38 0.073
BC029155-1|AAH29155.1| 489|Homo sapiens Unknown (protein for IM... 38 0.096
D12621-1|BAA02145.1| 389|Homo sapiens cytochrome P-450LTBV prot... 36 0.22
BC067442-1|AAH67442.1| 501|Homo sapiens cytochrome P450, family... 36 0.29
AK000366-1|BAA91114.1| 408|Homo sapiens protein ( Homo sapiens ... 36 0.29
AF090320-1|AAD19877.1| 501|Homo sapiens sterol 12-alpha-hydroxy... 36 0.29
AF090318-1|AAC63037.1| 462|Homo sapiens sterol 12-alpha hydroxy... 36 0.29
AC004914-2|AAP21887.1| 311|Homo sapiens unknown protein. 36 0.29
AC004914-1|AAD21788.1| 348|Homo sapiens unknown protein. 36 0.29
AY803272-1|AAW30454.1| 1492|Homo sapiens AKAP9-BRAF fusion prote... 36 0.39
AK094090-1|BAC04283.1| 153|Homo sapiens protein ( Homo sapiens ... 36 0.39
AJ131693-1|CAB40713.1| 3908|Homo sapiens AKAP450 protein protein. 36 0.39
AJ010770-1|CAA09361.1| 3911|Homo sapiens Hyperion protein protein. 36 0.39
AF026245-1|AAB86384.1| 1642|Homo sapiens yotiao protein. 36 0.39
AC000066-1|AAC60380.1| 1620|Homo sapiens yotiao protein. 36 0.39
AB019691-1|BAA78718.1| 3899|Homo sapiens Centrosome- and Golgi-l... 36 0.39
BC067444-1|AAH67444.1| 501|Homo sapiens cytochrome P450, family... 35 0.68
BC067441-1|AAH67441.1| 501|Homo sapiens cytochrome P450, family... 35 0.68
BC067434-1|AAH67434.1| 501|Homo sapiens cytochrome P450, family... 35 0.68
L40392-1|AAC41999.1| 273|Homo sapiens protein ( Homo sapiens (c... 34 0.90
M17398-1|AAA35740.1| 393|Homo sapiens protein ( Human cytochrom... 34 1.2
BC113391-1|AAI13392.1| 839|Homo sapiens RBM25 protein protein. 34 1.2
BC113389-1|AAI13390.1| 839|Homo sapiens RBM25 protein protein. 34 1.2
AF109907-1|AAC97961.1| 735|Homo sapiens S164 protein. 34 1.2
AC004858-3|AAF19255.1| 784|Homo sapiens WUGSC:H_DJ0687K01.2 pro... 34 1.2
DQ680079-1|ABG25922.1| 347|Homo sapiens truncated cytochrome P4... 31 6.3
AB038224-9|BAB20054.1| 518|Homo sapiens calmodulin-dependent ph... 31 6.3
AB038224-8|BAB20053.1| 501|Homo sapiens calmodulin-dependent ph... 31 6.3
AB038224-7|BAB20057.1| 511|Homo sapiens calmodulin-dependent ph... 31 6.3
AK222993-1|BAD96713.1| 224|Homo sapiens FK506-binding protein 3... 31 8.4
>AK131190-1|BAD18388.1| 372|Homo sapiens .-.-). protein.
Length = 372
Score = 151 bits (367), Expect = 4e-36
Identities = 95/336 (28%), Positives = 177/336 (52%), Gaps = 25/336 (7%)
Query: 107 PKTIKLYSAAIDEVAQEMMNR---MKSKLDENNRLQAKFDDEMNLWALESIGVVAFGIRL 163
PK + +YS +++V +++ R ++S+ ++ + +D +++E + + + RL
Sbjct: 12 PKDVAIYSGEVNQVIADLIKRIYLLRSQAEDGETV-TNVNDLFFKYSMEGVATILYESRL 70
Query: 164 NCFDPNLAENSPEK-KLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLS 222
C + ++ + + E + +E + +F S P F +++ + + S
Sbjct: 71 GCLENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWREFCRSWDGLFKFS 130
Query: 223 KYFINKAMRNINKNENKPDEQKGVLEKLLDINE----EYAYIMATDMLVAGVDTVANSIA 278
+ ++ +R+I ++ G L L +++ + Y T+ML+AGVDT + +++
Sbjct: 131 QIHVDNKLRDIQYQMDRGRRVSGGLLTYLFLSQALTLQEIYANVTEMLLAGVDTTSFTLS 190
Query: 279 ATLYLFAKNPEKQEKLREEVMSKESKRYL------------KACIKETMRMMPVVSGNLR 326
T+YL A++PE Q+ + E++ +R++ +A +KET+R+ PV+ GN R
Sbjct: 191 WTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLRLFPVLPGNGR 250
Query: 327 RTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPF 386
T ++ I GY +PKG +A H S +E++PR EF PERWL K D + F
Sbjct: 251 VTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLR-KGD---LDRVDNF 306
Query: 387 VMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
PFG GVRSCIGRRIAELEI + ++L++F ++
Sbjct: 307 GSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIK 342
>BC039307-1|AAH39307.1| 372|Homo sapiens FLJ16008 protein protein.
Length = 372
Score = 151 bits (365), Expect = 7e-36
Identities = 94/336 (27%), Positives = 177/336 (52%), Gaps = 25/336 (7%)
Query: 107 PKTIKLYSAAIDEVAQEMMNR---MKSKLDENNRLQAKFDDEMNLWALESIGVVAFGIRL 163
PK + +YS +++V +++ R ++S+ ++ + +D +++E + + + RL
Sbjct: 12 PKDVAIYSGEVNQVIADLIKRIYLLRSQAEDGETV-TNVNDLFFKYSMEGVATILYESRL 70
Query: 164 NCFDPNLAENSPEK-KLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLS 222
C + ++ + + E + +E + +F S P F +++ + + S
Sbjct: 71 GCLENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWREFCRSWDGLFKFS 130
Query: 223 KYFINKAMRNINKNENKPDEQKGVLEKLLDINE----EYAYIMATDMLVAGVDTVANSIA 278
+ ++ +R+I ++ G L L +++ + Y T+ML+AGVDT + +++
Sbjct: 131 QIHVDNKLRDIQYQMDRGRRVSGGLLTYLFLSQALTLQEIYANVTEMLLAGVDTTSFTLS 190
Query: 279 ATLYLFAKNPEKQEKLREEVMSKESKRYL------------KACIKETMRMMPVVSGNLR 326
T+Y+ A++PE Q+ + E++ +R++ +A +KET+R+ PV+ GN R
Sbjct: 191 WTVYILARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLRLFPVLPGNGR 250
Query: 327 RTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPF 386
T ++ I GY +PKG +A H S +E++PR EF PERWL K D + F
Sbjct: 251 VTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLR-KGD---LDRVDNF 306
Query: 387 VMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
PFG GVRSCIGRRIAELEI + ++L++F ++
Sbjct: 307 GSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIK 342
>AY178622-1|AAO21126.1| 531|Homo sapiens steroid hydroxylase
protein.
Length = 531
Score = 136 bits (328), Expect = 2e-31
Identities = 100/337 (29%), Positives = 163/337 (48%), Gaps = 27/337 (8%)
Query: 107 PKTIKLYSAAIDEVAQEMMNRMKSKLDENNRLQAKFDDEMNLW---ALESIGVVAFGIRL 163
P LY+ A +EV + M R+ +L + + D L+ ALE+I + F R+
Sbjct: 168 PAEAALYTDAFNEVIDDFMTRL-DQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRI 226
Query: 164 NCFDPNLAENSPEKKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSK 223
C ++ E++ + + +F S F P W P +K+ + + K
Sbjct: 227 GCLQRSIPEDTVT--FVRSIGLMFQNSLYATFLPK-WTRPVLPFWKRYLDGWNAIFSFGK 283
Query: 224 YFINKAMRNINKNENK--PD--EQKGVLEKLL---DINEEYAYIMATDMLVAGVDTVANS 276
I++ + ++ PD + G L LL ++ A ++L+AGVDT +N+
Sbjct: 284 KLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNT 343
Query: 277 IAATLYLFAKNPEKQEKLREEVMS-------KESKRY-----LKACIKETMRMMPVVSGN 324
+ LY +K+PE Q+ L EEV+ + K + LKA +KET+R+ PVV N
Sbjct: 344 LTWALYHLSKDPEIQKALHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTN 403
Query: 325 LRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAH 384
R KE + G+ PK F H ++S + P F P RWL + + P H
Sbjct: 404 SRIIEKEIEVDGFLFPKNTQFVFCHYEVSRDPTAFSEPESFQPHRWLRN-SQPATPRIQH 462
Query: 385 PFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRV 421
PF PFG+GVR+C+GRRIAELE++ L ++++ ++V
Sbjct: 463 PFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKV 499
>M62401-1|AAA52142.1| 531|Homo sapiens sterol 27-hydroxylase
protein.
Length = 531
Score = 135 bits (327), Expect = 3e-31
Identities = 101/337 (29%), Positives = 162/337 (48%), Gaps = 27/337 (8%)
Query: 107 PKTIKLYSAAIDEVAQEMMNRMKSKLDENNRLQAKFDDEMNLW---ALESIGVVAFGIRL 163
P LY+ A +EV + M R+ +L + + D L+ ALE+I + F R+
Sbjct: 168 PAEAALYTDAFNEVIDDFMTRL-DQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRI 226
Query: 164 NCFDPNLAENSPEKKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSK 223
C ++ E++ + + +F S F P W P +K+ + + K
Sbjct: 227 GCLQRSIPEDTVT--FVRSIGLMFQNSLYATFLPK-WTRPVLPFWKRYLDGWNAIFSFGK 283
Query: 224 YFINKAMRNINKNENK--PD--EQKGVLEKLL---DINEEYAYIMATDMLVAGVDTVANS 276
I++ + ++ PD + G L LL ++ A ++L+AGVDT +N+
Sbjct: 284 KLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNT 343
Query: 277 IAATLYLFAKNPEKQEKLREEVMS-------KESKRY-----LKACIKETMRMMPVVSGN 324
+ LY +K+PE QE L EEV+ + K + LKA +KET+R+ PVV N
Sbjct: 344 LTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTN 403
Query: 325 LRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAH 384
R KE + G+ PK F H +S + P F P RWL + + P H
Sbjct: 404 SRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRN-SQPATPRIQH 462
Query: 385 PFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRV 421
PF PFG+GVR+C+GRRIAELE++ L ++++ ++V
Sbjct: 463 PFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKV 499
>BC051851-1|AAH51851.1| 531|Homo sapiens cytochrome P450, family
27, subfamily A, polypeptide 1 protein.
Length = 531
Score = 135 bits (327), Expect = 3e-31
Identities = 101/337 (29%), Positives = 162/337 (48%), Gaps = 27/337 (8%)
Query: 107 PKTIKLYSAAIDEVAQEMMNRMKSKLDENNRLQAKFDDEMNLW---ALESIGVVAFGIRL 163
P LY+ A +EV + M R+ +L + + D L+ ALE+I + F R+
Sbjct: 168 PAEAALYTDAFNEVIDDFMTRL-DQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRI 226
Query: 164 NCFDPNLAENSPEKKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSK 223
C ++ E++ + + +F S F P W P +K+ + + K
Sbjct: 227 GCLQRSIPEDTVT--FVRSIGLMFQNSLYATFLPK-WTRPVLPFWKRYLDGWNAIFSFGK 283
Query: 224 YFINKAMRNINKNENK--PD--EQKGVLEKLL---DINEEYAYIMATDMLVAGVDTVANS 276
I++ + ++ PD + G L LL ++ A ++L+AGVDT +N+
Sbjct: 284 KLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNT 343
Query: 277 IAATLYLFAKNPEKQEKLREEVMS-------KESKRY-----LKACIKETMRMMPVVSGN 324
+ LY +K+PE QE L EEV+ + K + LKA +KET+R+ PVV N
Sbjct: 344 LTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTN 403
Query: 325 LRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAH 384
R KE + G+ PK F H +S + P F P RWL + + P H
Sbjct: 404 SRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRN-SQPATPRIQH 462
Query: 385 PFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRV 421
PF PFG+GVR+C+GRRIAELE++ L ++++ ++V
Sbjct: 463 PFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKV 499
>BC040430-1|AAH40430.1| 531|Homo sapiens cytochrome P450, family
27, subfamily A, polypeptide 1 protein.
Length = 531
Score = 135 bits (327), Expect = 3e-31
Identities = 101/337 (29%), Positives = 162/337 (48%), Gaps = 27/337 (8%)
Query: 107 PKTIKLYSAAIDEVAQEMMNRMKSKLDENNRLQAKFDDEMNLW---ALESIGVVAFGIRL 163
P LY+ A +EV + M R+ +L + + D L+ ALE+I + F R+
Sbjct: 168 PAEAALYTDAFNEVIDDFMTRL-DQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRI 226
Query: 164 NCFDPNLAENSPEKKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSK 223
C ++ E++ + + +F S F P W P +K+ + + K
Sbjct: 227 GCLQRSIPEDTVT--FVRSIGLMFQNSLYATFLPK-WTRPVLPFWKRYLDGWNAIFSFGK 283
Query: 224 YFINKAMRNINKNENK--PD--EQKGVLEKLL---DINEEYAYIMATDMLVAGVDTVANS 276
I++ + ++ PD + G L LL ++ A ++L+AGVDT +N+
Sbjct: 284 KLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNT 343
Query: 277 IAATLYLFAKNPEKQEKLREEVMS-------KESKRY-----LKACIKETMRMMPVVSGN 324
+ LY +K+PE QE L EEV+ + K + LKA +KET+R+ PVV N
Sbjct: 344 LTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTN 403
Query: 325 LRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAH 384
R KE + G+ PK F H +S + P F P RWL + + P H
Sbjct: 404 SRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRN-SQPATPRIQH 462
Query: 385 PFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRV 421
PF PFG+GVR+C+GRRIAELE++ L ++++ ++V
Sbjct: 463 PFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKV 499
>X59812-1|CAA42481.1| 530|Homo sapiens Vitamin D3 25-hydroxylase
protein.
Length = 530
Score = 134 bits (325), Expect = 5e-31
Identities = 101/337 (29%), Positives = 162/337 (48%), Gaps = 27/337 (8%)
Query: 107 PKTIKLYSAAIDEVAQEMMNRMKSKLDENNRLQAKFDDEMNLW---ALESIGVVAFGIRL 163
P LY+ A +EV + M R+ +L + + D L+ ALE+I + F R+
Sbjct: 167 PAERALYTDAFNEVIDDFMTRL-DQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRI 225
Query: 164 NCFDPNLAENSPEKKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSK 223
C ++ E++ + + +F S F P W P +K+ + + K
Sbjct: 226 GCLQRSIPEDTVT--FVRSIGLMFQNSLYATFLPK-WTRPVLPFWKRYLDGWNAIFSFGK 282
Query: 224 YFINKAMRNINKNENK--PD--EQKGVLEKLL---DINEEYAYIMATDMLVAGVDTVANS 276
I++ + ++ PD + G L LL ++ A ++L+AGVDT +N+
Sbjct: 283 KLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNT 342
Query: 277 IAATLYLFAKNPEKQEKLREEVMS-------KESKRY-----LKACIKETMRMMPVVSGN 324
+ LY +K+PE QE L EEV+ + K + LKA +KET+R+ PVV N
Sbjct: 343 LTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTN 402
Query: 325 LRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAH 384
R KE + G+ PK F H +S + P F P RWL + + P H
Sbjct: 403 SRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRN-SQPATPRIQH 461
Query: 385 PFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRV 421
PF PFG+GVR+C+GRRIAELE++ L ++++ ++V
Sbjct: 462 PFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKV 498
>AY288916-1|AAP31972.1| 508|Homo sapiens cytochrome P450, family
27, subfamily B, polypeptide 1 protein.
Length = 508
Score = 134 bits (323), Expect = 8e-31
Identities = 105/342 (30%), Positives = 158/342 (46%), Gaps = 36/342 (10%)
Query: 107 PKTIKLYSAAIDEVAQEMMNRMKSKLDENNRLQAKFDD---EMNLWALESIGVVAFGIRL 163
P+ Y+ ++ V +++ R++ + A D E + LE I V G RL
Sbjct: 148 PQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRL 207
Query: 164 NCFDPNLAENSPEKKLIECVHQIFNLSNQLDFQPSLW--HIFSTPTYKKAMKMFQL---- 217
C + + ++ + I V +F +S L W H+ P + Q+
Sbjct: 208 GCLEAQVPPDT--ETFIRAVGSVF-VSTLLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFA 264
Query: 218 QEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIM---ATDMLVAGVDTVA 274
Q + + AMRN + E K E L L E A + T++L+AGVDTV+
Sbjct: 265 QRHVERREAEAAMRNGGQPE-KDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVS 323
Query: 275 NSIAATLYLFAKNPEKQEKLREEV---MSKESKRY-----------LKACIKETMRMMPV 320
N+++ LY +++PE Q L E+ +S S Y LKA +KE +R+ PV
Sbjct: 324 NTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPV 383
Query: 321 VSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYY 380
V GN R K+ ++ Y +PK V H S +P P F P RWL + P
Sbjct: 384 VPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTP--- 440
Query: 381 GKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
HPF PFGFG RSC+GRR+AELE++ L +IL +F V+
Sbjct: 441 ---HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQ 479
>AF256213-1|AAG00416.1| 508|Homo sapiens 25- hydroxyvitamin
D-1-alpha-hydroxylase protein.
Length = 508
Score = 134 bits (323), Expect = 8e-31
Identities = 105/342 (30%), Positives = 158/342 (46%), Gaps = 36/342 (10%)
Query: 107 PKTIKLYSAAIDEVAQEMMNRMKSKLDENNRLQAKFDD---EMNLWALESIGVVAFGIRL 163
P+ Y+ ++ V +++ R++ + A D E + LE I V G RL
Sbjct: 148 PQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRL 207
Query: 164 NCFDPNLAENSPEKKLIECVHQIFNLSNQLDFQPSLW--HIFSTPTYKKAMKMFQL---- 217
C + + ++ + I V +F +S L W H+ P + Q+
Sbjct: 208 GCLEAQVPPDT--ETFIRAVGSVF-VSTLLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFA 264
Query: 218 QEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIM---ATDMLVAGVDTVA 274
Q + + AMRN + E K E L L E A + T++L+AGVDTV+
Sbjct: 265 QRHVERREAEAAMRNGGQPE-KDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVS 323
Query: 275 NSIAATLYLFAKNPEKQEKLREEV---MSKESKRY-----------LKACIKETMRMMPV 320
N+++ LY +++PE Q L E+ +S S Y LKA +KE +R+ PV
Sbjct: 324 NTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPV 383
Query: 321 VSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYY 380
V GN R K+ ++ Y +PK V H S +P P F P RWL + P
Sbjct: 384 VPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTP--- 440
Query: 381 GKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
HPF PFGFG RSC+GRR+AELE++ L +IL +F V+
Sbjct: 441 ---HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQ 479
>AF246895-1|AAF64299.1| 508|Homo sapiens 25-hydroxyvitamin
D-1-alpha-hydroxylase protein.
Length = 508
Score = 134 bits (323), Expect = 8e-31
Identities = 105/342 (30%), Positives = 158/342 (46%), Gaps = 36/342 (10%)
Query: 107 PKTIKLYSAAIDEVAQEMMNRMKSKLDENNRLQAKFDD---EMNLWALESIGVVAFGIRL 163
P+ Y+ ++ V +++ R++ + A D E + LE I V G RL
Sbjct: 148 PQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRL 207
Query: 164 NCFDPNLAENSPEKKLIECVHQIFNLSNQLDFQPSLW--HIFSTPTYKKAMKMFQL---- 217
C + + ++ + I V +F +S L W H+ P + Q+
Sbjct: 208 GCLEAQVPPDT--ETFIRAVGSVF-VSTLLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFA 264
Query: 218 QEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIM---ATDMLVAGVDTVA 274
Q + + AMRN + E K E L L E A + T++L+AGVDTV+
Sbjct: 265 QRHVERREAEAAMRNGGQPE-KDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVS 323
Query: 275 NSIAATLYLFAKNPEKQEKLREEV---MSKESKRY-----------LKACIKETMRMMPV 320
N+++ LY +++PE Q L E+ +S S Y LKA +KE +R+ PV
Sbjct: 324 NTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPV 383
Query: 321 VSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYY 380
V GN R K+ ++ Y +PK V H S +P P F P RWL + P
Sbjct: 384 VPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTP--- 440
Query: 381 GKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
HPF PFGFG RSC+GRR+AELE++ L +IL +F V+
Sbjct: 441 ---HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQ 479
>AF027152-1|AAC51854.1| 508|Homo sapiens P450 25-hydroxyvitamin D-1
alpha hydroxylase protein.
Length = 508
Score = 134 bits (323), Expect = 8e-31
Identities = 105/342 (30%), Positives = 158/342 (46%), Gaps = 36/342 (10%)
Query: 107 PKTIKLYSAAIDEVAQEMMNRMKSKLDENNRLQAKFDD---EMNLWALESIGVVAFGIRL 163
P+ Y+ ++ V +++ R++ + A D E + LE I V G RL
Sbjct: 148 PQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRL 207
Query: 164 NCFDPNLAENSPEKKLIECVHQIFNLSNQLDFQPSLW--HIFSTPTYKKAMKMFQL---- 217
C + + ++ + I V +F +S L W H+ P + Q+
Sbjct: 208 GCLEAQVPPDT--ETFIRAVGSVF-VSTLLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFA 264
Query: 218 QEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIM---ATDMLVAGVDTVA 274
Q + + AMRN + E K E L L E A + T++L+AGVDTV+
Sbjct: 265 QRHVERREAEAAMRNGGQPE-KDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVS 323
Query: 275 NSIAATLYLFAKNPEKQEKLREEV---MSKESKRY-----------LKACIKETMRMMPV 320
N+++ LY +++PE Q L E+ +S S Y LKA +KE +R+ PV
Sbjct: 324 NTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPV 383
Query: 321 VSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYY 380
V GN R K+ ++ Y +PK V H S +P P F P RWL + P
Sbjct: 384 VPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTP--- 440
Query: 381 GKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
HPF PFGFG RSC+GRR+AELE++ L +IL +F V+
Sbjct: 441 ---HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQ 479
>AF020192-1|AAC51853.1| 508|Homo sapiens 25-hydroxyvitamin
D-1-alpha-hydroxylase protein.
Length = 508
Score = 134 bits (323), Expect = 8e-31
Identities = 105/342 (30%), Positives = 158/342 (46%), Gaps = 36/342 (10%)
Query: 107 PKTIKLYSAAIDEVAQEMMNRMKSKLDENNRLQAKFDD---EMNLWALESIGVVAFGIRL 163
P+ Y+ ++ V +++ R++ + A D E + LE I V G RL
Sbjct: 148 PQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRL 207
Query: 164 NCFDPNLAENSPEKKLIECVHQIFNLSNQLDFQPSLW--HIFSTPTYKKAMKMFQL---- 217
C + + ++ + I V +F +S L W H+ P + Q+
Sbjct: 208 GCLEAQVPPDT--ETFIRAVGSVF-VSTLLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFA 264
Query: 218 QEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIM---ATDMLVAGVDTVA 274
Q + + AMRN + E K E L L E A + T++L+AGVDTV+
Sbjct: 265 QRHVERREAEAAMRNGGQPE-KDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVS 323
Query: 275 NSIAATLYLFAKNPEKQEKLREEV---MSKESKRY-----------LKACIKETMRMMPV 320
N+++ LY +++PE Q L E+ +S S Y LKA +KE +R+ PV
Sbjct: 324 NTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPV 383
Query: 321 VSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYY 380
V GN R K+ ++ Y +PK V H S +P P F P RWL + P
Sbjct: 384 VPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTP--- 440
Query: 381 GKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
HPF PFGFG RSC+GRR+AELE++ L +IL +F V+
Sbjct: 441 ---HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQ 479
>AB006987-1|BAA23418.1| 508|Homo sapiens 25-hydroxyvitamin D3
1-alpha-hydroxylase protein.
Length = 508
Score = 134 bits (323), Expect = 8e-31
Identities = 105/342 (30%), Positives = 158/342 (46%), Gaps = 36/342 (10%)
Query: 107 PKTIKLYSAAIDEVAQEMMNRMKSKLDENNRLQAKFDD---EMNLWALESIGVVAFGIRL 163
P+ Y+ ++ V +++ R++ + A D E + LE I V G RL
Sbjct: 148 PQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRL 207
Query: 164 NCFDPNLAENSPEKKLIECVHQIFNLSNQLDFQPSLW--HIFSTPTYKKAMKMFQL---- 217
C + + ++ + I V +F +S L W H+ P + Q+
Sbjct: 208 GCLEAQVPPDT--ETFIRAVGSVF-VSTLLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFA 264
Query: 218 QEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIM---ATDMLVAGVDTVA 274
Q + + AMRN + E K E L L E A + T++L+AGVDTV+
Sbjct: 265 QRHVERREAEAAMRNGGQPE-KDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVS 323
Query: 275 NSIAATLYLFAKNPEKQEKLREEV---MSKESKRY-----------LKACIKETMRMMPV 320
N+++ LY +++PE Q L E+ +S S Y LKA +KE +R+ PV
Sbjct: 324 NTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPV 383
Query: 321 VSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYY 380
V GN R K+ ++ Y +PK V H S +P P F P RWL + P
Sbjct: 384 VPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTP--- 440
Query: 381 GKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
HPF PFGFG RSC+GRR+AELE++ L +IL +F V+
Sbjct: 441 ---HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQ 479
>AB005990-1|BAA22657.1| 508|Homo sapiens 25-hydroxyvitamin D3
1alpha-hydroxylase protein.
Length = 508
Score = 134 bits (323), Expect = 8e-31
Identities = 105/342 (30%), Positives = 158/342 (46%), Gaps = 36/342 (10%)
Query: 107 PKTIKLYSAAIDEVAQEMMNRMKSKLDENNRLQAKFDD---EMNLWALESIGVVAFGIRL 163
P+ Y+ ++ V +++ R++ + A D E + LE I V G RL
Sbjct: 148 PQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRL 207
Query: 164 NCFDPNLAENSPEKKLIECVHQIFNLSNQLDFQPSLW--HIFSTPTYKKAMKMFQL---- 217
C + + ++ + I V +F +S L W H+ P + Q+
Sbjct: 208 GCLEAQVPPDT--ETFIRAVGSVF-VSTLLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFA 264
Query: 218 QEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIM---ATDMLVAGVDTVA 274
Q + + AMRN + E K E L L E A + T++L+AGVDTV+
Sbjct: 265 QRHVERREAEAAMRNGGQPE-KDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVS 323
Query: 275 NSIAATLYLFAKNPEKQEKLREEV---MSKESKRY-----------LKACIKETMRMMPV 320
N+++ LY +++PE Q L E+ +S S Y LKA +KE +R+ PV
Sbjct: 324 NTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPV 383
Query: 321 VSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYY 380
V GN R K+ ++ Y +PK V H S +P P F P RWL + P
Sbjct: 384 VPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTP--- 440
Query: 381 GKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
HPF PFGFG RSC+GRR+AELE++ L +IL +F V+
Sbjct: 441 ---HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQ 479
>AB005989-1|BAA22656.1| 508|Homo sapiens 25-hydroxyvitamin D3
1alpha-hydroxylase protein.
Length = 508
Score = 134 bits (323), Expect = 8e-31
Identities = 105/342 (30%), Positives = 158/342 (46%), Gaps = 36/342 (10%)
Query: 107 PKTIKLYSAAIDEVAQEMMNRMKSKLDENNRLQAKFDD---EMNLWALESIGVVAFGIRL 163
P+ Y+ ++ V +++ R++ + A D E + LE I V G RL
Sbjct: 148 PQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRL 207
Query: 164 NCFDPNLAENSPEKKLIECVHQIFNLSNQLDFQPSLW--HIFSTPTYKKAMKMFQL---- 217
C + + ++ + I V +F +S L W H+ P + Q+
Sbjct: 208 GCLEAQVPPDT--ETFIRAVGSVF-VSTLLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFA 264
Query: 218 QEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIM---ATDMLVAGVDTVA 274
Q + + AMRN + E K E L L E A + T++L+AGVDTV+
Sbjct: 265 QRHVERREAEAAMRNGGQPE-KDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVS 323
Query: 275 NSIAATLYLFAKNPEKQEKLREEV---MSKESKRY-----------LKACIKETMRMMPV 320
N+++ LY +++PE Q L E+ +S S Y LKA +KE +R+ PV
Sbjct: 324 NTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPV 383
Query: 321 VSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYY 380
V GN R K+ ++ Y +PK V H S +P P F P RWL + P
Sbjct: 384 VPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTP--- 440
Query: 381 GKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
HPF PFGFG RSC+GRR+AELE++ L +IL +F V+
Sbjct: 441 ---HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQ 479
>AB005038-1|BAA23416.1| 508|Homo sapiens 25-hydroxyvitamin D3
1-alpha-hydroxylase protein.
Length = 508
Score = 134 bits (323), Expect = 8e-31
Identities = 105/342 (30%), Positives = 158/342 (46%), Gaps = 36/342 (10%)
Query: 107 PKTIKLYSAAIDEVAQEMMNRMKSKLDENNRLQAKFDD---EMNLWALESIGVVAFGIRL 163
P+ Y+ ++ V +++ R++ + A D E + LE I V G RL
Sbjct: 148 PQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRL 207
Query: 164 NCFDPNLAENSPEKKLIECVHQIFNLSNQLDFQPSLW--HIFSTPTYKKAMKMFQL---- 217
C + + ++ + I V +F +S L W H+ P + Q+
Sbjct: 208 GCLEAQVPPDT--ETFIRAVGSVF-VSTLLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFA 264
Query: 218 QEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIM---ATDMLVAGVDTVA 274
Q + + AMRN + E K E L L E A + T++L+AGVDTV+
Sbjct: 265 QRHVERREAEAAMRNGGQPE-KDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVS 323
Query: 275 NSIAATLYLFAKNPEKQEKLREEV---MSKESKRY-----------LKACIKETMRMMPV 320
N+++ LY +++PE Q L E+ +S S Y LKA +KE +R+ PV
Sbjct: 324 NTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPV 383
Query: 321 VSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYY 380
V GN R K+ ++ Y +PK V H S +P P F P RWL + P
Sbjct: 384 VPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTP--- 440
Query: 381 GKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
HPF PFGFG RSC+GRR+AELE++ L +IL +F V+
Sbjct: 441 ---HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQ 479
>X05367-1|CAA28965.1| 521|Homo sapiens desmolase protein.
Length = 521
Score = 121 bits (292), Expect = 5e-27
Identities = 93/334 (27%), Positives = 159/334 (47%), Gaps = 26/334 (7%)
Query: 107 PKTIKLYSAAIDEVAQEMMNRMKSKLDE--NNRLQAKFDDEMNLWALESIGVVAFGIRLN 164
P+ K + +D V+++ ++ + ++ + + D++ +A ESI V FG R
Sbjct: 161 PEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQG 220
Query: 165 CFDPNLAENSPEKKLIECVHQIFNLS-NQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSK 223
+ + N ++ I+ ++Q+F+ S L+ P L+ +F T T+K + + + +
Sbjct: 221 MLEEVV--NPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVILSKAD 278
Query: 224 YFINKAMRNINKNENKPDEQKGVLEKLL-DINEEYAYIMA--TDMLVAGVDTVANSIAAT 280
+ + + + + +G+L +LL D + I A T+ML GVDT + ++
Sbjct: 279 IYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWH 338
Query: 281 LYLFAKNPEKQEKLREEVMSKESKRY------------LKACIKETMRMMPVVSGNLRRT 328
LY A+N + Q+ LR EV++ + LKA IKET+R+ P+ R
Sbjct: 339 LYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYL 398
Query: 329 TKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVM 388
+ + Y +P V A L + P F P RWL+ + Y+
Sbjct: 399 VNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLG---- 454
Query: 389 APFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
FG+GVR C+GRRIAELE+ FL +LENFRVE
Sbjct: 455 --FGWGVRQCLGRRIAELEMTIFLINMLENFRVE 486
>BC032329-1|AAH32329.1| 521|Homo sapiens cytochrome P450, family
11, subfamily A, polypeptide 1 protein.
Length = 521
Score = 121 bits (292), Expect = 5e-27
Identities = 93/334 (27%), Positives = 159/334 (47%), Gaps = 26/334 (7%)
Query: 107 PKTIKLYSAAIDEVAQEMMNRMKSKLDE--NNRLQAKFDDEMNLWALESIGVVAFGIRLN 164
P+ K + +D V+++ ++ + ++ + + D++ +A ESI V FG R
Sbjct: 161 PEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQG 220
Query: 165 CFDPNLAENSPEKKLIECVHQIFNLS-NQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSK 223
+ + N ++ I+ ++Q+F+ S L+ P L+ +F T T+K + + + +
Sbjct: 221 MLEEVV--NPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKAD 278
Query: 224 YFINKAMRNINKNENKPDEQKGVLEKLL-DINEEYAYIMA--TDMLVAGVDTVANSIAAT 280
+ + + + + +G+L +LL D + I A T+ML GVDT + ++
Sbjct: 279 IYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWH 338
Query: 281 LYLFAKNPEKQEKLREEVMSKESKRY------------LKACIKETMRMMPVVSGNLRRT 328
LY A+N + Q+ LR EV++ + LKA IKET+R+ P+ R
Sbjct: 339 LYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYL 398
Query: 329 TKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVM 388
+ + Y +P V A L + P F P RWL+ + Y+
Sbjct: 399 VNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLG---- 454
Query: 389 APFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
FG+GVR C+GRRIAELE+ FL +LENFRVE
Sbjct: 455 --FGWGVRQCLGRRIAELEMTIFLINMLENFRVE 486
>M14565-1|AAA52162.1| 521|Homo sapiens CYP11A protein.
Length = 521
Score = 120 bits (290), Expect = 8e-27
Identities = 93/334 (27%), Positives = 159/334 (47%), Gaps = 26/334 (7%)
Query: 107 PKTIKLYSAAIDEVAQEMMNRMKSKLDE--NNRLQAKFDDEMNLWALESIGVVAFGIRLN 164
P+ K + +D V+++ ++ + ++ + + D++ +A ESI V FG R
Sbjct: 161 PEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQG 220
Query: 165 CFDPNLAENSPEKKLIECVHQIFNLS-NQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSK 223
+ + N ++ I+ ++Q+F+ S L+ P L+ +F T T+K + + + +
Sbjct: 221 MLEEVV--NPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKAD 278
Query: 224 YFINKAMRNINKNENKPDEQKGVLEKLL-DINEEYAYIMA--TDMLVAGVDTVANSIAAT 280
+ + + + + +G+L +LL D + I A T+ML GVDT + ++
Sbjct: 279 IYTQNFYWELRQKGSVHHDYRGMLYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWH 338
Query: 281 LYLFAKNPEKQEKLREEVMSKESKRY------------LKACIKETMRMMPVVSGNLRRT 328
LY A+N + Q+ LR EV++ + LKA IKET+R+ P+ R
Sbjct: 339 LYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYL 398
Query: 329 TKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVM 388
+ + Y +P V A L + P F P RWL+ + Y+
Sbjct: 399 VNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLG---- 454
Query: 389 APFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
FG+GVR C+GRRIAELE+ FL +LENFRVE
Sbjct: 455 --FGWGVRQCLGRRIAELEMTIFLINMLENFRVE 486
>L13286-1|AAA62379.1| 513|Homo sapiens 1,25-dihydroxyvitamin D3
24-hydroxylase protein.
Length = 513
Score = 120 bits (290), Expect = 8e-27
Identities = 98/325 (30%), Positives = 161/325 (49%), Gaps = 36/325 (11%)
Query: 117 IDEVAQEMMNRMKSKLDENNRLQAKFDDEMNLWALESIGVVAFGIRLNCFDPNLAENSPE 176
I+EV + M R+ DE ++ + E+N W+ ESI +V + R N + +
Sbjct: 178 INEVLADFMGRIDELCDERGHVEDLYS-ELNKWSFESICLVLYEKRFGLLQKNAGDEAVN 236
Query: 177 KKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSKYFINKAMRNINKN 236
I + + + ++ P H S T K++Q L+ I K+++ N
Sbjct: 237 --FIMAIKTMMSTFGRMMVTPVELHK-SLNT-----KVWQ-GHTLAWDTIFKSVKACIDN 287
Query: 237 ENKPDEQKGVLEKLLDI------NEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEK 290
+ Q+ + L DI +++ Y T++ +A V+T ANS+ LY ++NP+
Sbjct: 288 RLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQV 347
Query: 291 QEKLREEVMS--KESKR----------YLKACIKETMRMMPVVSGNLRRTTKEYNILG-Y 337
Q+KL +E+ S E++R YLKAC+KE+MR+ P V RT + +LG Y
Sbjct: 348 QQKLLKEIQSVLPENQRPREEDLRNMPYLKACLKESMRLTPGVPFT-TRTLDKATVLGEY 406
Query: 338 HVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRS 397
+PKG + Q L S E+++ ++F PERWL +K K +PF PFG G R
Sbjct: 407 ALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKE------KINPFAHLPFGVGKRM 460
Query: 398 CIGRRIAELEIETFLTKILENFRVE 422
CIGRR+AEL++ L I+ + ++
Sbjct: 461 CIGRRLAELQLHLALCWIVRKYDIQ 485
>AY858838-1|AAW50795.1| 372|Homo sapiens vitamin D 24-hydroxylase
splice variant protein.
Length = 372
Score = 120 bits (289), Expect = 1e-26
Identities = 98/325 (30%), Positives = 159/325 (48%), Gaps = 36/325 (11%)
Query: 117 IDEVAQEMMNRMKSKLDENNRLQAKFDDEMNLWALESIGVVAFGIRLNCFDPNLAENSPE 176
I+EV + M R+ DE ++ + E+N W+ ESI +V + R N + +
Sbjct: 37 INEVLADFMGRIDELCDERGHVEDLYS-ELNKWSFESICLVLYEKRFGLLQKNAGDEAVN 95
Query: 177 KKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSKYFINKAMRNINKN 236
I + + + ++ P H S T K++Q L+ I K+++ N
Sbjct: 96 --FIMAIKTMMSTFGRMMVTPVELHK-SLNT-----KVWQ-DHTLAWDTIFKSVKACIDN 146
Query: 237 ENKPDEQKGVLEKLLDI------NEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEK 290
+ Q+ + L DI +++ Y T++ +A V+T ANS+ LY ++NP+
Sbjct: 147 RLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQV 206
Query: 291 QEKLREEVMS---------KESKR---YLKACIKETMRMMPVVSGNLRRTTKEYNILG-Y 337
Q+KL +E+ S E R YLKAC+KE+MR+ P V RT + +LG Y
Sbjct: 207 QQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFT-TRTLDKATVLGEY 265
Query: 338 HVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRS 397
+PKG + Q L S E+++ ++F PERWL +K K +PF PFG G R
Sbjct: 266 ALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKE------KINPFAHLPFGVGKRM 319
Query: 398 CIGRRIAELEIETFLTKILENFRVE 422
CIGRR+AEL++ L I+ + ++
Sbjct: 320 CIGRRLAELQLHLALCWIVRKYDIQ 344
>AL138805-3|CAB91829.1| 514|Homo sapiens cytochrome P450, family
24, subfamily A, polypeptide 1 protein.
Length = 514
Score = 120 bits (289), Expect = 1e-26
Identities = 98/325 (30%), Positives = 159/325 (48%), Gaps = 36/325 (11%)
Query: 117 IDEVAQEMMNRMKSKLDENNRLQAKFDDEMNLWALESIGVVAFGIRLNCFDPNLAENSPE 176
I+EV + M R+ DE ++ + E+N W+ ESI +V + R N + +
Sbjct: 179 INEVLADFMGRIDELCDERGHVEDLYS-ELNKWSFESICLVLYEKRFGLLQKNAGDEAVN 237
Query: 177 KKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSKYFINKAMRNINKN 236
I + + + ++ P H S T K++Q L+ I K+++ N
Sbjct: 238 --FIMAIKTMMSTFGRMMVTPVELHK-SLNT-----KVWQ-DHTLAWDTIFKSVKACIDN 288
Query: 237 ENKPDEQKGVLEKLLDI------NEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEK 290
+ Q+ + L DI +++ Y T++ +A V+T ANS+ LY ++NP+
Sbjct: 289 RLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQV 348
Query: 291 QEKLREEVMS---------KESKR---YLKACIKETMRMMPVVSGNLRRTTKEYNILG-Y 337
Q+KL +E+ S E R YLKAC+KE+MR+ P V RT + +LG Y
Sbjct: 349 QQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFT-TRTLDKATVLGEY 407
Query: 338 HVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRS 397
+PKG + Q L S E+++ ++F PERWL +K K +PF PFG G R
Sbjct: 408 ALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKE------KINPFAHLPFGVGKRM 461
Query: 398 CIGRRIAELEIETFLTKILENFRVE 422
CIGRR+AEL++ L I+ + ++
Sbjct: 462 CIGRRLAELQLHLALCWIVRKYDIQ 486
>AL138805-1|CAM27342.1| 372|Homo sapiens cytochrome P450, family
24, subfamily A, polypeptide 1 protein.
Length = 372
Score = 120 bits (289), Expect = 1e-26
Identities = 98/325 (30%), Positives = 159/325 (48%), Gaps = 36/325 (11%)
Query: 117 IDEVAQEMMNRMKSKLDENNRLQAKFDDEMNLWALESIGVVAFGIRLNCFDPNLAENSPE 176
I+EV + M R+ DE ++ + E+N W+ ESI +V + R N + +
Sbjct: 37 INEVLADFMGRIDELCDERGHVEDLYS-ELNKWSFESICLVLYEKRFGLLQKNAGDEAVN 95
Query: 177 KKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSKYFINKAMRNINKN 236
I + + + ++ P H S T K++Q L+ I K+++ N
Sbjct: 96 --FIMAIKTMMSTFGRMMVTPVELHK-SLNT-----KVWQ-DHTLAWDTIFKSVKACIDN 146
Query: 237 ENKPDEQKGVLEKLLDI------NEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEK 290
+ Q+ + L DI +++ Y T++ +A V+T ANS+ LY ++NP+
Sbjct: 147 RLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQV 206
Query: 291 QEKLREEVMS---------KESKR---YLKACIKETMRMMPVVSGNLRRTTKEYNILG-Y 337
Q+KL +E+ S E R YLKAC+KE+MR+ P V RT + +LG Y
Sbjct: 207 QQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFT-TRTLDKATVLGEY 265
Query: 338 HVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRS 397
+PKG + Q L S E+++ ++F PERWL +K K +PF PFG G R
Sbjct: 266 ALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKE------KINPFAHLPFGVGKRM 319
Query: 398 CIGRRIAELEIETFLTKILENFRVE 422
CIGRR+AEL++ L I+ + ++
Sbjct: 320 CIGRRLAELQLHLALCWIVRKYDIQ 344
>D13752-1|BAA02899.1| 503|Homo sapiens steroid 18-hydroxylase
protein.
Length = 503
Score = 115 bits (276), Expect = 4e-25
Identities = 91/338 (26%), Positives = 157/338 (46%), Gaps = 34/338 (10%)
Query: 106 NPKTIKLYSAAIDEVAQEMMNRMKSKLDENNRLQAKFDDEMNL--WALESIGVVAFGIRL 163
+PK ++ + +D VA++ +K K+ +N R D + ++ + +E+ + FG RL
Sbjct: 150 SPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERL 209
Query: 164 NCFDPNLAENSPEKKLIECVHQI---FNLSNQLDFQP-SLWHIFSTPTYKKAMKMFQLQE 219
L +SP + +H + F + QL F P SL S +K+ + +
Sbjct: 210 G-----LVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIF 264
Query: 220 DLSKYFINKAMRNINKNENKPDEQKGVLEKLL---DINEEYAYIMATDMLVAGVDTVANS 276
I K + + N +P G++ +LL +++ E + ++ VDT A
Sbjct: 265 QYGDNCIQKIYQELAFN--RPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFP 322
Query: 277 IAATLYLFAKNPEKQEKLREEVMSKESK------------RYLKACIKETMRMMPVVSGN 324
+ TL+ A+NP+ Q+ LR+E ++ + L+A +KET+R+ PV
Sbjct: 323 LLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFL 382
Query: 325 LRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAH 384
R + + + YH+P G V L +PRP + P+RWL + G
Sbjct: 383 ERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIR------GSGR 436
Query: 385 PFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
F PFGFG+R C+GRR+AE E+ L +L++F VE
Sbjct: 437 NFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVE 474
>X54741-1|CAA38539.1| 503|Homo sapiens aldosterone synthase
(P-450aldo) protein.
Length = 503
Score = 113 bits (271), Expect = 2e-24
Identities = 90/338 (26%), Positives = 158/338 (46%), Gaps = 34/338 (10%)
Query: 106 NPKTIKLYSAAIDEVAQEMMNRMKSKLDENNRLQAKFDDEMNL--WALESIGVVAFGIRL 163
+PK ++ + +D VA++ +K K+ +N R D + ++ + +E+ + FG RL
Sbjct: 150 SPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERL 209
Query: 164 NCFDPNLAENSPEKKLIECVHQI---FNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQED 220
L +SP + +H + F + QL F P + P K + F+ +
Sbjct: 210 G-----LVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWIRPKVWK--EHFEAWDC 262
Query: 221 LSKYFINKAMRNINKNE-NKPDEQKGVLEKLL---DINEEYAYIMATDMLVAGVDTVANS 276
+ +Y N + + N+P G++ +LL +++ E + ++ VDT A
Sbjct: 263 IFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFP 322
Query: 277 IAATLYLFAKNPEKQEKLREEVMSKESK------------RYLKACIKETMRMMPVVSGN 324
+ TL+ A+NP+ Q+ LR+E ++ + L+A +KET+R+ PV
Sbjct: 323 LLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFL 382
Query: 325 LRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAH 384
R + + + YH+P G V L +PRP + P+RWL + G
Sbjct: 383 ERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIR------GSGR 436
Query: 385 PFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
F PFGFG+R C+GRR+AE E+ L +L++F VE
Sbjct: 437 NFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVE 474
>M32881-1|AAA35741.1| 503|Homo sapiens protein ( Human steroid
11-beta-hydroxylase-like-enzyme (CYP11B2) gene, exon 9.
).
Length = 503
Score = 110 bits (265), Expect = 9e-24
Identities = 89/338 (26%), Positives = 155/338 (45%), Gaps = 34/338 (10%)
Query: 106 NPKTIKLYSAAIDEVAQEMMNRMKSKLDENNRLQAKFDDEMNL--WALESIGVVAFGIRL 163
+PK ++ + +D VA++ ++ K+ +N R D + ++ + +E+ + FG RL
Sbjct: 150 SPKAVQRFLPMVDAVARDFSQALRKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERL 209
Query: 164 NCFDPNLAENSPEKKLIECVHQI---FNLSNQLDFQP-SLWHIFSTPTYKKAMKMFQLQE 219
L +SP + +H + F + QL F P SL S +K+ + +
Sbjct: 210 G-----LVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIF 264
Query: 220 DLSKYFINKAMRNINKNENKPDEQKGVLEKLL---DINEEYAYIMATDMLVAGVDTVANS 276
I K + + N +P G++ +LL +++ E + ++ VDT A
Sbjct: 265 QYGDNCIQKIYQELAFN--RPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFP 322
Query: 277 IAATLYLFAKNPEKQEKLREEVMSKESK------------RYLKACIKETMRMMPVVSGN 324
+ TL+ A+NP+ Q+ LR+E ++ + L+A +KET+R+ PV
Sbjct: 323 LLMTLFELARNPDVQQILRKESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFL 382
Query: 325 LRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAH 384
R + + + YH+P G V L +PRP + P+RWL + G
Sbjct: 383 ERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIR------GSGR 436
Query: 385 PFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
PFGFG+R C+GRR+AE E+ L +L+ F VE
Sbjct: 437 NLHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKRFLVE 474
>S67623-1|AAB29308.1| 257|Homo sapiens 25-hydroxyvitamin D
24-hydroxylase cytochrome P450 subunit protein.
Length = 257
Score = 110 bits (264), Expect = 1e-23
Identities = 67/183 (36%), Positives = 103/183 (56%), Gaps = 20/183 (10%)
Query: 253 INEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEVMS---------KES 303
++++ Y T++ +A V+T ANS+ LY ++NP+ Q+KL +E+ S E
Sbjct: 54 LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAED 113
Query: 304 KR---YLKACIKETMRMMPVVSGNLRRTTKEYNILG-YHVPKGIDVAFAHQDLSSMEEHY 359
R YLKAC+KE+MR+ P V RT + +LG Y +PKG + Q L S E+++
Sbjct: 114 LRNMPYLKACLKESMRLTPSVPFT-TRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNF 172
Query: 360 PRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
++F PERWL +K K +PF PFG G R CIGRR+AEL++ L I+ +
Sbjct: 173 EDSSQFRPERWLQEKE------KINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKY 226
Query: 420 RVE 422
++
Sbjct: 227 DIQ 229
>X55764-1|CAA39290.1| 503|Homo sapiens protein ( Human mRNA for
cytochrome P-450 (11 Beta). ).
Length = 503
Score = 109 bits (261), Expect = 3e-23
Identities = 94/345 (27%), Positives = 163/345 (47%), Gaps = 37/345 (10%)
Query: 100 DPESAANPKTIKLYSAAIDEVAQEMMNRMKSKLDENNRLQAKFDDEMNL--WALESIGVV 157
+PE +P ++ + +D VA++ +K K+ +N R D + ++ + +E+ +
Sbjct: 145 NPE-VLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 203
Query: 158 AFGIRLNCFDPNLAENSPEKKLIECVHQI---FNLSNQLDFQPSLWHIFSTPTYKKAMKM 214
FG RL L +SP + +H + F + QL F P +++P K +
Sbjct: 204 LFGERLG-----LVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWK--EH 256
Query: 215 FQLQEDLSKYFINKAMRNINKNE-NKPDEQKGVLEKLLDINEEYA--YIMATDM-LVAG- 269
F+ + + +Y N + + ++P + ++ +LL +N E + I A M L AG
Sbjct: 257 FEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELL-LNAELSPDAIKANSMELTAGS 315
Query: 270 VDTVANSIAATLYLFAKNPEKQEKLREEVMSKESK------------RYLKACIKETMRM 317
VDT + TL+ A+NP Q+ LR+E ++ + L+A +KET+R+
Sbjct: 316 VDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRL 375
Query: 318 MPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDP 377
PV R + + + YH+P G V L +PRP + P+RWL +
Sbjct: 376 YPVGLFLERVVSSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIR--- 432
Query: 378 LYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
G F PFGFG+R C+GRR+AE E+ L +L++ +VE
Sbjct: 433 ---GSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVE 474
>M32879-1|AAA52149.1| 503|Homo sapiens CYP11B1 protein.
Length = 503
Score = 109 bits (261), Expect = 3e-23
Identities = 94/345 (27%), Positives = 163/345 (47%), Gaps = 37/345 (10%)
Query: 100 DPESAANPKTIKLYSAAIDEVAQEMMNRMKSKLDENNRLQAKFDDEMNL--WALESIGVV 157
+PE +P ++ + +D VA++ +K K+ +N R D + ++ + +E+ +
Sbjct: 145 NPE-VLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 203
Query: 158 AFGIRLNCFDPNLAENSPEKKLIECVHQI---FNLSNQLDFQPSLWHIFSTPTYKKAMKM 214
FG RL L +SP + +H + F + QL F P +++P K +
Sbjct: 204 LFGERLG-----LVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWK--EH 256
Query: 215 FQLQEDLSKYFINKAMRNINKNE-NKPDEQKGVLEKLLDINEEYA--YIMATDM-LVAG- 269
F+ + + +Y N + + ++P + ++ +LL +N E + I A M L AG
Sbjct: 257 FEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELL-LNAELSPDAIKANSMELTAGS 315
Query: 270 VDTVANSIAATLYLFAKNPEKQEKLREEVMSKESK------------RYLKACIKETMRM 317
VDT + TL+ A+NP Q+ LR+E ++ + L+A +KET+R+
Sbjct: 316 VDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRL 375
Query: 318 MPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDP 377
PV R + + + YH+P G V L +PRP + P+RWL +
Sbjct: 376 YPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIR--- 432
Query: 378 LYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
G F PFGFG+R C+GRR+AE E+ L +L++ +VE
Sbjct: 433 ---GSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVE 474
>BC096287-1|AAH96287.1| 503|Homo sapiens cytochrome P450, family
11, subfamily B, polypeptide 1 protein.
Length = 503
Score = 109 bits (261), Expect = 3e-23
Identities = 94/345 (27%), Positives = 163/345 (47%), Gaps = 37/345 (10%)
Query: 100 DPESAANPKTIKLYSAAIDEVAQEMMNRMKSKLDENNRLQAKFDDEMNL--WALESIGVV 157
+PE +P ++ + +D VA++ +K K+ +N R D + ++ + +E+ +
Sbjct: 145 NPE-VLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 203
Query: 158 AFGIRLNCFDPNLAENSPEKKLIECVHQI---FNLSNQLDFQPSLWHIFSTPTYKKAMKM 214
FG RL L +SP + +H + F + QL F P +++P K +
Sbjct: 204 LFGERLG-----LVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWK--EH 256
Query: 215 FQLQEDLSKYFINKAMRNINKNE-NKPDEQKGVLEKLLDINEEYA--YIMATDM-LVAG- 269
F+ + + +Y N + + ++P + ++ +LL +N E + I A M L AG
Sbjct: 257 FEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELL-LNAELSPDAIKANSMELTAGS 315
Query: 270 VDTVANSIAATLYLFAKNPEKQEKLREEVMSKESK------------RYLKACIKETMRM 317
VDT + TL+ A+NP Q+ LR+E ++ + L+A +KET+R+
Sbjct: 316 VDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRL 375
Query: 318 MPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDP 377
PV R + + + YH+P G V L +PRP + P+RWL +
Sbjct: 376 YPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIR--- 432
Query: 378 LYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
G F PFGFG+R C+GRR+AE E+ L +L++ +VE
Sbjct: 433 ---GSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVE 474
>BC096285-1|AAH96285.1| 574|Homo sapiens CYP11B1 protein protein.
Length = 574
Score = 109 bits (261), Expect = 3e-23
Identities = 94/345 (27%), Positives = 163/345 (47%), Gaps = 37/345 (10%)
Query: 100 DPESAANPKTIKLYSAAIDEVAQEMMNRMKSKLDENNRLQAKFDDEMNL--WALESIGVV 157
+PE +P ++ + +D VA++ +K K+ +N R D + ++ + +E+ +
Sbjct: 216 NPE-VLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 274
Query: 158 AFGIRLNCFDPNLAENSPEKKLIECVHQI---FNLSNQLDFQPSLWHIFSTPTYKKAMKM 214
FG RL L +SP + +H + F + QL F P +++P K +
Sbjct: 275 LFGERLG-----LVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWK--EH 327
Query: 215 FQLQEDLSKYFINKAMRNINKNE-NKPDEQKGVLEKLLDINEEYA--YIMATDM-LVAG- 269
F+ + + +Y N + + ++P + ++ +LL +N E + I A M L AG
Sbjct: 328 FEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELL-LNAELSPDAIKANSMELTAGS 386
Query: 270 VDTVANSIAATLYLFAKNPEKQEKLREEVMSKESK------------RYLKACIKETMRM 317
VDT + TL+ A+NP Q+ LR+E ++ + L+A +KET+R+
Sbjct: 387 VDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRL 446
Query: 318 MPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDP 377
PV R + + + YH+P G V L +PRP + P+RWL +
Sbjct: 447 YPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIR--- 503
Query: 378 LYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
G F PFGFG+R C+GRR+AE E+ L +L++ +VE
Sbjct: 504 ---GSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVE 545
>AF478474-1|AAL84813.1| 503|Homo sapiens mutated cytochrome
P-450c11 protein protein.
Length = 503
Score = 107 bits (258), Expect = 6e-23
Identities = 93/345 (26%), Positives = 163/345 (47%), Gaps = 37/345 (10%)
Query: 100 DPESAANPKTIKLYSAAIDEVAQEMMNRMKSKLDENNRLQAKFDDEMNL--WALESIGVV 157
+PE +P ++ + +D VA++ +K K+ +N R D + ++ + +E+ +
Sbjct: 145 NPE-VLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 203
Query: 158 AFGIRLNCFDPNLAENSPEKKLIECVHQI---FNLSNQLDFQPSLWHIFSTPTYKKAMKM 214
FG RL L +SP + +H + F + QL F P +++P K +
Sbjct: 204 LFGERLG-----LVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWK--EH 256
Query: 215 FQLQEDLSKYFINKAMRNINKNE-NKPDEQKGVLEKLLDINEEYA--YIMATDM-LVAG- 269
F+ + + +Y N + + ++P + ++ +LL +N E + I A M L AG
Sbjct: 257 FEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELL-LNAELSPDAIKANSMELTAGS 315
Query: 270 VDTVANSIAATLYLFAKNPEKQEKLREEVMSKESK------------RYLKACIKETMRM 317
+DT + TL+ A+NP Q+ LR+E ++ + L+A +KET+R+
Sbjct: 316 MDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRL 375
Query: 318 MPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDP 377
PV R + + + YH+P G V L +PRP + P+RWL +
Sbjct: 376 YPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIR--- 432
Query: 378 LYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
G F PFGFG+R C+GRR+AE E+ L +L++ +VE
Sbjct: 433 ---GSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVE 474
>AF233624-1|AAF99278.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 93.5 bits (222), Expect = 1e-18
Identities = 62/194 (31%), Positives = 88/194 (45%), Gaps = 18/194 (9%)
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-------------MSKESKRYLKACIK 312
L+AG + + N+++ YL A NP+ QEKL EV +E YL I
Sbjct: 340 LIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIA 399
Query: 313 ETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
ET+RM P R ++ +LG +P G + A L EH+P P F PER+ A
Sbjct: 400 ETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPENFNPERFTA 459
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPPKIIQ 432
+ + PF PFG G RSC+G R+ LE++ L +L FR + +Q
Sbjct: 460 EARQ-----QHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQ 514
Query: 433 TSINYFTGPFNFVF 446
GP N V+
Sbjct: 515 LESKSALGPKNGVY 528
>M80647-1|AAA60618.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 93.1 bits (221), Expect = 2e-18
Identities = 62/194 (31%), Positives = 88/194 (45%), Gaps = 18/194 (9%)
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-------------MSKESKRYLKACIK 312
L+AG + + N+++ YL A NP+ QEKL EV +E YL I
Sbjct: 340 LIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIA 399
Query: 313 ETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
ET+RM P R ++ +LG +P G + A L EH+P P F PER+ A
Sbjct: 400 ETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTA 459
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPPKIIQ 432
+ + PF PFG G RSC+G R+ LE++ L +L FR + +Q
Sbjct: 460 EARQ-----QHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQ 514
Query: 433 TSINYFTGPFNFVF 446
GP N V+
Sbjct: 515 LESKSALGPKNGVY 528
>BC041157-1|AAH41157.1| 534|Homo sapiens thromboxane A synthase 1
(platelet, cytochrome P450, family 5, subfamily A)
protein.
Length = 534
Score = 93.1 bits (221), Expect = 2e-18
Identities = 62/194 (31%), Positives = 88/194 (45%), Gaps = 18/194 (9%)
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-------------MSKESKRYLKACIK 312
L+AG + + N+++ YL A NP+ QEKL EV +E YL I
Sbjct: 340 LIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIA 399
Query: 313 ETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
ET+RM P R ++ +LG +P G + A L EH+P P F PER+ A
Sbjct: 400 ETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTA 459
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPPKIIQ 432
+ + PF PFG G RSC+G R+ LE++ L +L FR + +Q
Sbjct: 460 EARQ-----QHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQ 514
Query: 433 TSINYFTGPFNFVF 446
GP N V+
Sbjct: 515 LESKSALGPKNGVY 528
>BC014117-1|AAH14117.1| 466|Homo sapiens TBXAS1 protein protein.
Length = 466
Score = 93.1 bits (221), Expect = 2e-18
Identities = 62/194 (31%), Positives = 88/194 (45%), Gaps = 18/194 (9%)
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-------------MSKESKRYLKACIK 312
L+AG + + N+++ YL A NP+ QEKL EV +E YL I
Sbjct: 272 LIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIA 331
Query: 313 ETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
ET+RM P R ++ +LG +P G + A L EH+P P F PER+ A
Sbjct: 332 ETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTA 391
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPPKIIQ 432
+ + PF PFG G RSC+G R+ LE++ L +L FR + +Q
Sbjct: 392 EARQ-----QHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQ 446
Query: 433 TSINYFTGPFNFVF 446
GP N V+
Sbjct: 447 LESKSALGPKNGVY 460
>AK223466-1|BAD97186.1| 534|Homo sapiens thromboxane A synthase 1
(platelet, cytochrome P450, family 5, subfamily A) iso
protein.
Length = 534
Score = 93.1 bits (221), Expect = 2e-18
Identities = 62/194 (31%), Positives = 88/194 (45%), Gaps = 18/194 (9%)
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-------------MSKESKRYLKACIK 312
L+AG + + N+++ YL A NP+ QEKL EV +E YL I
Sbjct: 340 LIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIA 399
Query: 313 ETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
ET+RM P R ++ +LG +P G + A L EH+P P F PER+ A
Sbjct: 400 ETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTA 459
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPPKIIQ 432
+ + PF PFG G RSC+G R+ LE++ L +L FR + +Q
Sbjct: 460 EARQ-----QHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQ 514
Query: 433 TSINYFTGPFNFVF 446
GP N V+
Sbjct: 515 LESKSALGPKNGVY 528
>AF233625-1|AAF99279.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 93.1 bits (221), Expect = 2e-18
Identities = 62/194 (31%), Positives = 88/194 (45%), Gaps = 18/194 (9%)
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-------------MSKESKRYLKACIK 312
L+AG + + N+++ YL A NP+ QEKL EV +E YL I
Sbjct: 340 LIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIA 399
Query: 313 ETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
ET+RM P R ++ +LG +P G + A L EH+P P F PER+ A
Sbjct: 400 ETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTA 459
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPPKIIQ 432
+ + PF PFG G RSC+G R+ LE++ L +L FR + +Q
Sbjct: 460 EARQ-----QHQPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQ 514
Query: 433 TSINYFTGPFNFVF 446
GP N V+
Sbjct: 515 LESKSALGPKNGVY 528
>AF233623-1|AAF99277.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 93.1 bits (221), Expect = 2e-18
Identities = 62/194 (31%), Positives = 88/194 (45%), Gaps = 18/194 (9%)
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-------------MSKESKRYLKACIK 312
L+AG + + N+++ YL A NP+ QEKL EV +E YL I
Sbjct: 340 LIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIA 399
Query: 313 ETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
ET+RM P R ++ +LG +P G + A L EH+P P F PER+ A
Sbjct: 400 ETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPKTFNPERFTA 459
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPPKIIQ 432
+ + PF PFG G RSC+G R+ LE++ L +L FR + +Q
Sbjct: 460 EARQ-----QHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQ 514
Query: 433 TSINYFTGPFNFVF 446
GP N V+
Sbjct: 515 LESKSALGPKNGVY 528
>AF233622-1|AAF99276.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 93.1 bits (221), Expect = 2e-18
Identities = 62/194 (31%), Positives = 88/194 (45%), Gaps = 18/194 (9%)
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-------------MSKESKRYLKACIK 312
L+AG + + N+++ YL A NP+ QEKL EV +E YL I
Sbjct: 340 LIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIA 399
Query: 313 ETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
ET+RM P R ++ +LG +P G + A L EH+P P F PER+ A
Sbjct: 400 ETLRMYPPAFRFTREAAEDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTA 459
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPPKIIQ 432
+ + PF PFG G RSC+G R+ LE++ L +L FR + +Q
Sbjct: 460 EARQ-----QHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQ 514
Query: 433 TSINYFTGPFNFVF 446
GP N V+
Sbjct: 515 LESKSALGPKNGVY 528
>AF233620-1|AAF99274.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 93.1 bits (221), Expect = 2e-18
Identities = 62/194 (31%), Positives = 88/194 (45%), Gaps = 18/194 (9%)
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-------------MSKESKRYLKACIK 312
L+AG + + N+++ YL A NP+ QEKL EV +E YL I
Sbjct: 340 LIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIA 399
Query: 313 ETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
ET+RM P R ++ +LG +P G + A L EH+P P F PER+ A
Sbjct: 400 ETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTA 459
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPPKIIQ 432
+ + PF PFG G RSC+G R+ LE++ L +L FR + +Q
Sbjct: 460 EARQ-----QHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQ 514
Query: 433 TSINYFTGPFNFVF 446
GP N V+
Sbjct: 515 LESKSALGPKNGVY 528
>AF233619-1|AAF99273.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 93.1 bits (221), Expect = 2e-18
Identities = 62/194 (31%), Positives = 88/194 (45%), Gaps = 18/194 (9%)
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-------------MSKESKRYLKACIK 312
L+AG + + N+++ YL A NP+ QEKL EV +E YL I
Sbjct: 340 LIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIA 399
Query: 313 ETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
ET+RM P R ++ +LG +P G + A L EH+P P F PER+ A
Sbjct: 400 ETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTA 459
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPPKIIQ 432
+ + PF PFG G RSC+G R+ LE++ L +L FR + +Q
Sbjct: 460 EARQ-----QHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQ 514
Query: 433 TSINYFTGPFNFVF 446
GP N V+
Sbjct: 515 LESKSALGPKNGVY 528
>AF233618-1|AAF99272.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 93.1 bits (221), Expect = 2e-18
Identities = 62/194 (31%), Positives = 88/194 (45%), Gaps = 18/194 (9%)
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-------------MSKESKRYLKACIK 312
L+AG + + N+++ YL A NP+ QEKL EV +E YL I
Sbjct: 340 LIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIA 399
Query: 313 ETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
ET+RM P R ++ +LG +P G + A L EH+P P F PER+ A
Sbjct: 400 ETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTA 459
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPPKIIQ 432
+ + PF PFG G RSC+G R+ LE++ L +L FR + +Q
Sbjct: 460 EARQ-----QHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQ 514
Query: 433 TSINYFTGPFNFVF 446
GP N V+
Sbjct: 515 LESKSALGPKNGVY 528
>AF233617-1|AAF99271.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 93.1 bits (221), Expect = 2e-18
Identities = 62/194 (31%), Positives = 88/194 (45%), Gaps = 18/194 (9%)
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-------------MSKESKRYLKACIK 312
L+AG + + N+++ YL A NP+ QEKL EV +E YL I
Sbjct: 340 LIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIA 399
Query: 313 ETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
ET+RM P R ++ +LG +P G + A L EH+P P F PER+ A
Sbjct: 400 ETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTA 459
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPPKIIQ 432
+ + PF PFG G RSC+G R+ LE++ L +L FR + +Q
Sbjct: 460 EARQ-----QHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQ 514
Query: 433 TSINYFTGPFNFVF 446
GP N V+
Sbjct: 515 LESKSALGPKNGVY 528
>AF233616-1|AAF99270.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 93.1 bits (221), Expect = 2e-18
Identities = 62/194 (31%), Positives = 88/194 (45%), Gaps = 18/194 (9%)
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-------------MSKESKRYLKACIK 312
L+AG + + N+++ YL A NP+ QEKL EV +E YL I
Sbjct: 340 LIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIA 399
Query: 313 ETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
ET+RM P R ++ +LG +P G + A L EH+P P F PER+ A
Sbjct: 400 ETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTA 459
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPPKIIQ 432
+ + PF PFG G RSC+G R+ LE++ L +L FR + +Q
Sbjct: 460 EARQ-----QHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQ 514
Query: 433 TSINYFTGPFNFVF 446
GP N V+
Sbjct: 515 LESKSALGPKNGVY 528
>AF233615-1|AAF99269.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 93.1 bits (221), Expect = 2e-18
Identities = 62/194 (31%), Positives = 88/194 (45%), Gaps = 18/194 (9%)
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-------------MSKESKRYLKACIK 312
L+AG + + N+++ YL A NP+ QEKL EV +E YL I
Sbjct: 340 LIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIA 399
Query: 313 ETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
ET+RM P R ++ +LG +P G + A L EH+P P F PER+ A
Sbjct: 400 ETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTA 459
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPPKIIQ 432
+ + PF PFG G RSC+G R+ LE++ L +L FR + +Q
Sbjct: 460 EARQ-----QHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQ 514
Query: 433 TSINYFTGPFNFVF 446
GP N V+
Sbjct: 515 LESKSALGPKNGVY 528
>M28253-1|AAA36404.1| 239|Homo sapiens cytochrome P-450-scc
protein.
Length = 239
Score = 92.3 bits (219), Expect = 3e-18
Identities = 68/196 (34%), Positives = 97/196 (49%), Gaps = 21/196 (10%)
Query: 242 EQKGVLEKLL-DINEEYAYIMA--TDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV 298
+ +G+L +LL D + I A T+ML GVDT + ++ LY A+N + Q+ LR EV
Sbjct: 15 DYRGMLYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEV 74
Query: 299 MSKESKRY------------LKACIKETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVA 346
++ + LKA IKET+R+ P+ R + + Y +P V
Sbjct: 75 LAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQ 134
Query: 347 FAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAEL 406
A L + P F P RWL+ + Y+ FG+GVR C+GRRIAEL
Sbjct: 135 VAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLG------FGWGVRQCLGRRIAEL 188
Query: 407 EIETFLTKILENFRVE 422
E+ FL +LENFRVE
Sbjct: 189 EMTIFLINMLENFRVE 204
>AF233621-1|AAF99275.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 91.9 bits (218), Expect = 4e-18
Identities = 61/194 (31%), Positives = 88/194 (45%), Gaps = 18/194 (9%)
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-------------MSKESKRYLKACIK 312
L+AG + + N+++ Y+ A NP+ QEKL EV +E YL I
Sbjct: 340 LIAGYEIITNTLSFATYVLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIA 399
Query: 313 ETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
ET+RM P R ++ +LG +P G + A L EH+P P F PER+ A
Sbjct: 400 ETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTA 459
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPPKIIQ 432
+ + PF PFG G RSC+G R+ LE++ L +L FR + +Q
Sbjct: 460 EARQ-----QHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQ 514
Query: 433 TSINYFTGPFNFVF 446
GP N V+
Sbjct: 515 LESKSALGPKNGVY 528
>BC060857-1|AAH60857.1| 525|Homo sapiens cytochrome P450, family 4,
subfamily V, polypeptide 2 protein.
Length = 525
Score = 91.5 bits (217), Expect = 6e-18
Identities = 58/167 (34%), Positives = 85/167 (50%), Gaps = 18/167 (10%)
Query: 269 GVDTVANSIAATLYLFAKNPEKQEKLREE---VMSKESK----------RYLKACIKETM 315
G DT A +I +LYL NPE Q+K+ E V K + RYL+ IKET+
Sbjct: 330 GHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETL 389
Query: 316 RMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKN 375
R+ P V R +++ + GY V KG + L ++P P EF PER+ +
Sbjct: 390 RLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENA 449
Query: 376 DPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
G+ HP+ PF G R+CIG++ A +E +T L+ IL +F +E
Sbjct: 450 Q----GR-HPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIE 491
>AY422002-1|AAR31180.1| 525|Homo sapiens cytochrome P450 4V2
protein.
Length = 525
Score = 91.5 bits (217), Expect = 6e-18
Identities = 58/167 (34%), Positives = 85/167 (50%), Gaps = 18/167 (10%)
Query: 269 GVDTVANSIAATLYLFAKNPEKQEKLREE---VMSKESK----------RYLKACIKETM 315
G DT A +I +LYL NPE Q+K+ E V K + RYL+ IKET+
Sbjct: 330 GHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETL 389
Query: 316 RMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKN 375
R+ P V R +++ + GY V KG + L ++P P EF PER+ +
Sbjct: 390 RLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENA 449
Query: 376 DPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
G+ HP+ PF G R+CIG++ A +E +T L+ IL +F +E
Sbjct: 450 Q----GR-HPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIE 491
>AK126473-1|BAC86562.1| 503|Homo sapiens protein ( Homo sapiens
cDNA FLJ44509 fis, clone UTERU3001585, weakly similar
to Cytochrome P450 4c3 (EC 1.14.-.-). ).
Length = 503
Score = 91.5 bits (217), Expect = 6e-18
Identities = 58/167 (34%), Positives = 85/167 (50%), Gaps = 18/167 (10%)
Query: 269 GVDTVANSIAATLYLFAKNPEKQEKLREE---VMSKESK----------RYLKACIKETM 315
G DT A +I +LYL NPE Q+K+ E V K + RYL+ IKET+
Sbjct: 308 GHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETL 367
Query: 316 RMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKN 375
R+ P V R +++ + GY V KG + L ++P P EF PER+ +
Sbjct: 368 RLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENA 427
Query: 376 DPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
G+ HP+ PF G R+CIG++ A +E +T L+ IL +F +E
Sbjct: 428 Q----GR-HPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIE 469
>AK122600-1|BAC85487.1| 525|Homo sapiens protein ( Homo sapiens
cDNA FLJ16007 fis, clone KIDNE2006580, weakly similar
to CYTOCHROME P450 4C1 (EC 1.14.14.1). ).
Length = 525
Score = 91.5 bits (217), Expect = 6e-18
Identities = 58/167 (34%), Positives = 85/167 (50%), Gaps = 18/167 (10%)
Query: 269 GVDTVANSIAATLYLFAKNPEKQEKLREE---VMSKESK----------RYLKACIKETM 315
G DT A +I +LYL NPE Q+K+ E V K + RYL+ IKET+
Sbjct: 330 GHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETL 389
Query: 316 RMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKN 375
R+ P V R +++ + GY V KG + L ++P P EF PER+ +
Sbjct: 390 RLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENA 449
Query: 376 DPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
G+ HP+ PF G R+CIG++ A +E +T L+ IL +F +E
Sbjct: 450 Q----GR-HPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIE 491
>D34625-1|BAA07011.1| 533|Homo sapiens thromboxane synthase
protein.
Length = 533
Score = 91.1 bits (216), Expect = 7e-18
Identities = 61/194 (31%), Positives = 87/194 (44%), Gaps = 18/194 (9%)
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-------------MSKESKRYLKACIK 312
L+AG + + N+++ YL A NP+ QEKL EV +E YL I
Sbjct: 339 LIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIA 398
Query: 313 ETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
ET+RM P R ++ +LG +P G + A L EH+P P F PER+ A
Sbjct: 399 ETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTA 458
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPPKIIQ 432
+ + PF PFG G RSC+G + LE++ L +L FR + +Q
Sbjct: 459 EARQ-----QHRPFTYLPFGAGPRSCLGVHLGLLEVKLTLLHVLHKFRFQACPETQVPLQ 513
Query: 433 TSINYFTGPFNFVF 446
GP N V+
Sbjct: 514 LESKSALGPKNGVY 527
>BC028102-1|AAH28102.1| 509|Homo sapiens cytochrome P450, family 4,
subfamily X, polypeptide 1 protein.
Length = 509
Score = 87.8 bits (208), Expect = 7e-17
Identities = 94/368 (25%), Positives = 155/368 (42%), Gaps = 37/368 (10%)
Query: 110 IKLYSAAIDEVAQEMMNRMKSKLDENNRLQAKFDDEMNLWALESIGVVAFGIRLNCFDPN 169
+K Y + + M+++ + K+ + + +N +L+ I AF NC N
Sbjct: 149 LKAYIEVMAHSVKMMLDKWE-KICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNC-QTN 206
Query: 170 LAENSPEKKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSKYFINKA 229
+ K + E IF+ L + + S Y+ K+ ++ + I +
Sbjct: 207 STHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYR-FQKLSRVLNQYTDTIIQER 265
Query: 230 MRNIN---KNENKPDEQ-KGVLEKLLDINEEYA--------YIMATDMLVAGVDTVANSI 277
+++ K +N P + + L+ +L +E + + L+AG DT+A SI
Sbjct: 266 KKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASI 325
Query: 278 AATLYLFAKNPEKQEKLREEVMS------------KESKRYLKACIKETMRMMPVVSGNL 325
+ LY A NPE QE+ REEV Y CIKET R++P V
Sbjct: 326 SWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLIPAVPSIS 385
Query: 326 RRTTKEYNIL-GYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAH 384
R +K G +P GI V + L + P F P R+ + +D + H
Sbjct: 386 RDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSD-----QRH 440
Query: 385 PFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPPKIIQTSINYF-TGPFN 443
P+ PF G R+CIG+ A +E++ + IL +FRV P P T N+F P N
Sbjct: 441 PYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVT---PDPTRPLTFPNHFILKPKN 497
Query: 444 FVFNDIKK 451
++ +KK
Sbjct: 498 GMYLHLKK 505
>AY358537-1|AAQ88901.1| 509|Homo sapiens EFSW1929 protein.
Length = 509
Score = 87.8 bits (208), Expect = 7e-17
Identities = 94/368 (25%), Positives = 155/368 (42%), Gaps = 37/368 (10%)
Query: 110 IKLYSAAIDEVAQEMMNRMKSKLDENNRLQAKFDDEMNLWALESIGVVAFGIRLNCFDPN 169
+K Y + + M+++ + K+ + + +N +L+ I AF NC N
Sbjct: 149 LKAYIEVMAHSVKMMLDKWE-KICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNC-QTN 206
Query: 170 LAENSPEKKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSKYFINKA 229
+ K + E IF+ L + + S Y+ K+ ++ + I +
Sbjct: 207 STHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYR-FQKLSRVLNQYTDTIIQER 265
Query: 230 MRNIN---KNENKPDEQ-KGVLEKLLDINEEYA--------YIMATDMLVAGVDTVANSI 277
+++ K +N P + + L+ +L +E + + L+AG DT+A SI
Sbjct: 266 KKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASI 325
Query: 278 AATLYLFAKNPEKQEKLREEVMS------------KESKRYLKACIKETMRMMPVVSGNL 325
+ LY A NPE QE+ REEV Y CIKET R++P V
Sbjct: 326 SWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLIPAVPSIS 385
Query: 326 RRTTKEYNIL-GYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAH 384
R +K G +P GI V + L + P F P R+ + +D + H
Sbjct: 386 RDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSD-----QRH 440
Query: 385 PFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPPKIIQTSINYF-TGPFN 443
P+ PF G R+CIG+ A +E++ + IL +FRV P P T N+F P N
Sbjct: 441 PYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVT---PDPTRPLTFPNHFILKPKN 497
Query: 444 FVFNDIKK 451
++ +KK
Sbjct: 498 GMYLHLKK 505
>AM040940-1|CAJ13826.1| 509|Homo sapiens cytochrome P450 protein.
Length = 509
Score = 87.8 bits (208), Expect = 7e-17
Identities = 94/368 (25%), Positives = 155/368 (42%), Gaps = 37/368 (10%)
Query: 110 IKLYSAAIDEVAQEMMNRMKSKLDENNRLQAKFDDEMNLWALESIGVVAFGIRLNCFDPN 169
+K Y + + M+++ + K+ + + +N +L+ I AF NC N
Sbjct: 149 LKAYIEVMAHSVKMMLDKWE-KICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNC-QTN 206
Query: 170 LAENSPEKKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSKYFINKA 229
+ K + E IF+ L + + S Y+ K+ ++ + I +
Sbjct: 207 STHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYR-FQKLSRVLNQYTDTIIQER 265
Query: 230 MRNIN---KNENKPDEQ-KGVLEKLLDINEEYA--------YIMATDMLVAGVDTVANSI 277
+++ K +N P + + L+ +L +E + + L+AG DT+A SI
Sbjct: 266 KKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASI 325
Query: 278 AATLYLFAKNPEKQEKLREEVMS------------KESKRYLKACIKETMRMMPVVSGNL 325
+ LY A NPE QE+ REEV Y CIKET R++P V
Sbjct: 326 SWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLIPAVPSIS 385
Query: 326 RRTTKEYNIL-GYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAH 384
R +K G +P GI V + L + P F P R+ + +D + H
Sbjct: 386 RDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSD-----QRH 440
Query: 385 PFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPPKIIQTSINYF-TGPFN 443
P+ PF G R+CIG+ A +E++ + IL +FRV P P T N+F P N
Sbjct: 441 PYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVT---PDPTRPLTFPNHFILKPKN 497
Query: 444 FVFNDIKK 451
++ +KK
Sbjct: 498 GMYLHLKK 505
>AL450996-1|CAH71035.1| 509|Homo sapiens cytochrome P450, family 4,
subfamily X, polypeptide 1 protein.
Length = 509
Score = 87.8 bits (208), Expect = 7e-17
Identities = 94/368 (25%), Positives = 155/368 (42%), Gaps = 37/368 (10%)
Query: 110 IKLYSAAIDEVAQEMMNRMKSKLDENNRLQAKFDDEMNLWALESIGVVAFGIRLNCFDPN 169
+K Y + + M+++ + K+ + + +N +L+ I AF NC N
Sbjct: 149 LKAYIEVMAHSVKMMLDKWE-KICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNC-QTN 206
Query: 170 LAENSPEKKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSKYFINKA 229
+ K + E IF+ L + + S Y+ K+ ++ + I +
Sbjct: 207 STHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYR-FQKLSRVLNQYTDTIIQER 265
Query: 230 MRNIN---KNENKPDEQ-KGVLEKLLDINEEYA--------YIMATDMLVAGVDTVANSI 277
+++ K +N P + + L+ +L +E + + L+AG DT+A SI
Sbjct: 266 KKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASI 325
Query: 278 AATLYLFAKNPEKQEKLREEVMS------------KESKRYLKACIKETMRMMPVVSGNL 325
+ LY A NPE QE+ REEV Y CIKET R++P V
Sbjct: 326 SWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLIPAVPSIS 385
Query: 326 RRTTKEYNIL-GYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAH 384
R +K G +P GI V + L + P F P R+ + +D + H
Sbjct: 386 RDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSD-----QRH 440
Query: 385 PFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPPKIIQTSINYF-TGPFN 443
P+ PF G R+CIG+ A +E++ + IL +FRV P P T N+F P N
Sbjct: 441 PYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVT---PDPTRPLTFPNHFILKPKN 497
Query: 444 FVFNDIKK 451
++ +KK
Sbjct: 498 GMYLHLKK 505
>AK098065-1|BAC05226.1| 509|Homo sapiens protein ( Homo sapiens
cDNA FLJ40746 fis, clone TRACH2000359, weakly similar to
CYTOCHROME P450 4A4 (EC 1.14.14.1). ).
Length = 509
Score = 87.8 bits (208), Expect = 7e-17
Identities = 94/368 (25%), Positives = 155/368 (42%), Gaps = 37/368 (10%)
Query: 110 IKLYSAAIDEVAQEMMNRMKSKLDENNRLQAKFDDEMNLWALESIGVVAFGIRLNCFDPN 169
+K Y + + M+++ + K+ + + +N +L+ I AF NC N
Sbjct: 149 LKAYIEVMAHSVKMMLDKWE-KICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNC-QTN 206
Query: 170 LAENSPEKKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSKYFINKA 229
+ K + E IF+ L + + S Y+ K+ ++ + I +
Sbjct: 207 STHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYR-FQKLSRVLNQYTDTIIQER 265
Query: 230 MRNIN---KNENKPDEQ-KGVLEKLLDINEEYA--------YIMATDMLVAGVDTVANSI 277
+++ K +N P + + L+ +L +E + + L+AG DT+A SI
Sbjct: 266 KKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASI 325
Query: 278 AATLYLFAKNPEKQEKLREEVMS------------KESKRYLKACIKETMRMMPVVSGNL 325
+ LY A NPE QE+ REEV Y CIKET R++P V
Sbjct: 326 SWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLIPAVPSIS 385
Query: 326 RRTTKEYNIL-GYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAH 384
R +K G +P GI V + L + P F P R+ + +D + H
Sbjct: 386 RDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSD-----QRH 440
Query: 385 PFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPPKIIQTSINYF-TGPFN 443
P+ PF G R+CIG+ A +E++ + IL +FRV P P T N+F P N
Sbjct: 441 PYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVT---PDPTRPLTFPNHFILKPKN 497
Query: 444 FVFNDIKK 451
++ +KK
Sbjct: 498 GMYLHLKK 505
>AK091806-1|BAC03751.1| 444|Homo sapiens protein ( Homo sapiens
cDNA FLJ34487 fis, clone HLUNG2004273, weakly similar to
CYTOCHROME P450 4A4 (EC 1.14.14.1). ).
Length = 444
Score = 87.8 bits (208), Expect = 7e-17
Identities = 94/368 (25%), Positives = 155/368 (42%), Gaps = 37/368 (10%)
Query: 110 IKLYSAAIDEVAQEMMNRMKSKLDENNRLQAKFDDEMNLWALESIGVVAFGIRLNCFDPN 169
+K Y + + M+++ + K+ + + +N +L+ I AF NC N
Sbjct: 84 LKAYIEVMAHSVKMMLDKWE-KICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNC-QTN 141
Query: 170 LAENSPEKKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSKYFINKA 229
+ K + E IF+ L + + S Y+ K+ ++ + I +
Sbjct: 142 STHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYR-FQKLSRVLNQYTDTIIQER 200
Query: 230 MRNIN---KNENKPDEQ-KGVLEKLLDINEEYA--------YIMATDMLVAGVDTVANSI 277
+++ K +N P + + L+ +L +E + + L+AG DT+A SI
Sbjct: 201 KKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASI 260
Query: 278 AATLYLFAKNPEKQEKLREEVMS------------KESKRYLKACIKETMRMMPVVSGNL 325
+ LY A NPE QE+ REEV Y CIKET R++P V
Sbjct: 261 SWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLIPAVPSIS 320
Query: 326 RRTTKEYNIL-GYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAH 384
R +K G +P GI V + L + P F P R+ + +D + H
Sbjct: 321 RDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSD-----QRH 375
Query: 385 PFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPPKIIQTSINYF-TGPFN 443
P+ PF G R+CIG+ A +E++ + IL +FRV P P T N+F P N
Sbjct: 376 PYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVT---PDPTRPLTFPNHFILKPKN 432
Query: 444 FVFNDIKK 451
++ +KK
Sbjct: 433 GMYLHLKK 440
>AK131355-1|BAD18508.1| 508|Homo sapiens protein ( Homo sapiens
cDNA FLJ16384 fis, clone TLIVE2007607, weakly similar
to CYTOCHROME P450 4A4 (EC 1.14.14.1). ).
Length = 508
Score = 87.4 bits (207), Expect = 9e-17
Identities = 93/368 (25%), Positives = 155/368 (42%), Gaps = 37/368 (10%)
Query: 110 IKLYSAAIDEVAQEMMNRMKSKLDENNRLQAKFDDEMNLWALESIGVVAFGIRLNCFDPN 169
+K Y + + M+++ + K+ + + +N +L+ + AF NC N
Sbjct: 148 LKAYIEVMAHSVKMMLDKWE-KICSTQDTSVEVYEHINSMSLDIVMKCAFSKETNC-QTN 205
Query: 170 LAENSPEKKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSKYFINKA 229
+ K + E IF+ L + + S Y+ K+ ++ + I +
Sbjct: 206 STHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYR-FQKLSRVLNQYTDTIIQER 264
Query: 230 MRNIN---KNENKPDEQ-KGVLEKLLDINEEYA--------YIMATDMLVAGVDTVANSI 277
+++ K +N P + + L+ +L +E + + L+AG DT+A SI
Sbjct: 265 KKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASI 324
Query: 278 AATLYLFAKNPEKQEKLREEVMS------------KESKRYLKACIKETMRMMPVVSGNL 325
+ LY A NPE QE+ REEV Y CIKET R++P V
Sbjct: 325 SWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLIPAVPSIS 384
Query: 326 RRTTKEYNIL-GYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAH 384
R +K G +P GI V + L + P F P R+ + +D + H
Sbjct: 385 RDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSD-----QRH 439
Query: 385 PFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPPKIIQTSINYF-TGPFN 443
P+ PF G R+CIG+ A +E++ + IL +FRV P P T N+F P N
Sbjct: 440 PYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVT---PDPTRPLTFPNHFILKPKN 496
Query: 444 FVFNDIKK 451
++ +KK
Sbjct: 497 GMYLHLKK 504
>M18907-1|AAA35745.1| 503|Homo sapiens protein ( Human P450 mRNA
encoding nifedipine oxidase, complete cds. ).
Length = 503
Score = 86.2 bits (204), Expect = 2e-16
Identities = 60/222 (27%), Positives = 105/222 (47%), Gaps = 24/222 (10%)
Query: 210 KAMKMFQLQEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIMATDMLVAG 269
K MK +L ED K+ ++ I+ +K E L L + + +I A G
Sbjct: 254 KRMKESRL-EDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA------G 306
Query: 270 VDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIKETMRM 317
+T ++ ++ +Y A +P+ Q+KL+EE+ + + YL + ET+R+
Sbjct: 307 YETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL 366
Query: 318 MPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDP 377
P+ R K+ I G +PKG+ V L +++ P +F+PER+ D
Sbjct: 367 FPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDN 426
Query: 378 LYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
+ P++ PFG G R+CIG R A + ++ L ++L+NF
Sbjct: 427 I-----DPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>DQ924960-1|ABI96208.1| 503|Homo sapiens cytochrome P450 family 3
subfamily A polypeptide 4 protein.
Length = 503
Score = 86.2 bits (204), Expect = 2e-16
Identities = 60/222 (27%), Positives = 105/222 (47%), Gaps = 24/222 (10%)
Query: 210 KAMKMFQLQEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIMATDMLVAG 269
K MK +L ED K+ ++ I+ +K E L L + + +I A G
Sbjct: 254 KRMKESRL-EDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA------G 306
Query: 270 VDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIKETMRM 317
+T ++ ++ +Y A +P+ Q+KL+EE+ + + YL + ET+R+
Sbjct: 307 YETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL 366
Query: 318 MPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDP 377
P+ R K+ I G +PKG+ V L +++ P +F+PER+ D
Sbjct: 367 FPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDN 426
Query: 378 LYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
+ P++ PFG G R+CIG R A + ++ L ++L+NF
Sbjct: 427 I-----DPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>DQ005611-1|AAY16980.1| 503|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 4 protein.
Length = 503
Score = 86.2 bits (204), Expect = 2e-16
Identities = 60/222 (27%), Positives = 105/222 (47%), Gaps = 24/222 (10%)
Query: 210 KAMKMFQLQEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIMATDMLVAG 269
K MK +L ED K+ ++ I+ +K E L L + + +I A G
Sbjct: 254 KRMKESRL-EDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA------G 306
Query: 270 VDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIKETMRM 317
+T ++ ++ +Y A +P+ Q+KL+EE+ + + YL + ET+R+
Sbjct: 307 YETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL 366
Query: 318 MPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDP 377
P+ R K+ I G +PKG+ V L +++ P +F+PER+ D
Sbjct: 367 FPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDN 426
Query: 378 LYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
+ P++ PFG G R+CIG R A + ++ L ++L+NF
Sbjct: 427 I-----DPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>BC101631-1|AAI01632.1| 503|Homo sapiens cytochrome P450, subfamily
IIIA, polypeptide 4 protein.
Length = 503
Score = 86.2 bits (204), Expect = 2e-16
Identities = 60/222 (27%), Positives = 105/222 (47%), Gaps = 24/222 (10%)
Query: 210 KAMKMFQLQEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIMATDMLVAG 269
K MK +L ED K+ ++ I+ +K E L L + + +I A G
Sbjct: 254 KRMKESRL-EDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA------G 306
Query: 270 VDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIKETMRM 317
+T ++ ++ +Y A +P+ Q+KL+EE+ + + YL + ET+R+
Sbjct: 307 YETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL 366
Query: 318 MPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDP 377
P+ R K+ I G +PKG+ V L +++ P +F+PER+ D
Sbjct: 367 FPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDN 426
Query: 378 LYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
+ P++ PFG G R+CIG R A + ++ L ++L+NF
Sbjct: 427 I-----DPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>BC069418-1|AAH69418.1| 503|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 4 protein.
Length = 503
Score = 86.2 bits (204), Expect = 2e-16
Identities = 60/222 (27%), Positives = 105/222 (47%), Gaps = 24/222 (10%)
Query: 210 KAMKMFQLQEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIMATDMLVAG 269
K MK +L ED K+ ++ I+ +K E L L + + +I A G
Sbjct: 254 KRMKESRL-EDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA------G 306
Query: 270 VDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIKETMRM 317
+T ++ ++ +Y A +P+ Q+KL+EE+ + + YL + ET+R+
Sbjct: 307 YETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL 366
Query: 318 MPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDP 377
P+ R K+ I G +PKG+ V L +++ P +F+PER+ D
Sbjct: 367 FPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDN 426
Query: 378 LYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
+ P++ PFG G R+CIG R A + ++ L ++L+NF
Sbjct: 427 I-----DPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>AJ563377-1|CAD91345.1| 353|Homo sapiens cytochrome P450 protein.
Length = 353
Score = 86.2 bits (204), Expect = 2e-16
Identities = 60/222 (27%), Positives = 105/222 (47%), Gaps = 24/222 (10%)
Query: 210 KAMKMFQLQEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIMATDMLVAG 269
K MK +L ED K+ ++ I+ +K E L L + + +I A G
Sbjct: 104 KRMKESRL-EDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA------G 156
Query: 270 VDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIKETMRM 317
+T ++ ++ +Y A +P+ Q+KL+EE+ + + YL + ET+R+
Sbjct: 157 YETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL 216
Query: 318 MPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDP 377
P+ R K+ I G +PKG+ V L +++ P +F+PER+ D
Sbjct: 217 FPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDN 276
Query: 378 LYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
+ P++ PFG G R+CIG R A + ++ L ++L+NF
Sbjct: 277 I-----DPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 313
>AJ563376-2|CAD91645.1| 430|Homo sapiens cytochrome P450 protein.
Length = 430
Score = 86.2 bits (204), Expect = 2e-16
Identities = 60/222 (27%), Positives = 105/222 (47%), Gaps = 24/222 (10%)
Query: 210 KAMKMFQLQEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIMATDMLVAG 269
K MK +L ED K+ ++ I+ +K E L L + + +I A G
Sbjct: 181 KRMKESRL-EDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA------G 233
Query: 270 VDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIKETMRM 317
+T ++ ++ +Y A +P+ Q+KL+EE+ + + YL + ET+R+
Sbjct: 234 YETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL 293
Query: 318 MPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDP 377
P+ R K+ I G +PKG+ V L +++ P +F+PER+ D
Sbjct: 294 FPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDN 353
Query: 378 LYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
+ P++ PFG G R+CIG R A + ++ L ++L+NF
Sbjct: 354 I-----DPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 390
>AJ563375-1|CAD91343.1| 503|Homo sapiens cytochrome P450 protein.
Length = 503
Score = 86.2 bits (204), Expect = 2e-16
Identities = 60/222 (27%), Positives = 105/222 (47%), Gaps = 24/222 (10%)
Query: 210 KAMKMFQLQEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIMATDMLVAG 269
K MK +L ED K+ ++ I+ +K E L L + + +I A G
Sbjct: 254 KRMKESRL-EDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA------G 306
Query: 270 VDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIKETMRM 317
+T ++ ++ +Y A +P+ Q+KL+EE+ + + YL + ET+R+
Sbjct: 307 YETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL 366
Query: 318 MPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDP 377
P+ R K+ I G +PKG+ V L +++ P +F+PER+ D
Sbjct: 367 FPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDN 426
Query: 378 LYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
+ P++ PFG G R+CIG R A + ++ L ++L+NF
Sbjct: 427 I-----DPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>AF280107-2|AAG32290.1| 503|Homo sapiens cytochrome P450
polypeptide 4 protein.
Length = 503
Score = 86.2 bits (204), Expect = 2e-16
Identities = 60/222 (27%), Positives = 105/222 (47%), Gaps = 24/222 (10%)
Query: 210 KAMKMFQLQEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIMATDMLVAG 269
K MK +L ED K+ ++ I+ +K E L L + + +I A G
Sbjct: 254 KRMKESRL-EDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA------G 306
Query: 270 VDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIKETMRM 317
+T ++ ++ +Y A +P+ Q+KL+EE+ + + YL + ET+R+
Sbjct: 307 YETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL 366
Query: 318 MPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDP 377
P+ R K+ I G +PKG+ V L +++ P +F+PER+ D
Sbjct: 367 FPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDN 426
Query: 378 LYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
+ P++ PFG G R+CIG R A + ++ L ++L+NF
Sbjct: 427 I-----DPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>AF209389-1|AAF21034.1| 503|Homo sapiens cytochrome P450 IIIA4
protein.
Length = 503
Score = 86.2 bits (204), Expect = 2e-16
Identities = 60/222 (27%), Positives = 105/222 (47%), Gaps = 24/222 (10%)
Query: 210 KAMKMFQLQEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIMATDMLVAG 269
K MK +L ED K+ ++ I+ +K E L L + + +I A G
Sbjct: 254 KRMKESRL-EDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA------G 306
Query: 270 VDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIKETMRM 317
+T ++ ++ +Y A +P+ Q+KL+EE+ + + YL + ET+R+
Sbjct: 307 YETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL 366
Query: 318 MPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDP 377
P+ R K+ I G +PKG+ V L +++ P +F+PER+ D
Sbjct: 367 FPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDN 426
Query: 378 LYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
+ P++ PFG G R+CIG R A + ++ L ++L+NF
Sbjct: 427 I-----DPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>AF182273-1|AAF13598.1| 503|Homo sapiens cytochrome P450-3A4
protein.
Length = 503
Score = 86.2 bits (204), Expect = 2e-16
Identities = 60/222 (27%), Positives = 105/222 (47%), Gaps = 24/222 (10%)
Query: 210 KAMKMFQLQEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIMATDMLVAG 269
K MK +L ED K+ ++ I+ +K E L L + + +I A G
Sbjct: 254 KRMKESRL-EDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA------G 306
Query: 270 VDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIKETMRM 317
+T ++ ++ +Y A +P+ Q+KL+EE+ + + YL + ET+R+
Sbjct: 307 CETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL 366
Query: 318 MPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDP 377
P+ R K+ I G +PKG+ V L +++ P +F+PER+ D
Sbjct: 367 FPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDN 426
Query: 378 LYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
+ P++ PFG G R+CIG R A + ++ L ++L+NF
Sbjct: 427 I-----DPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>M24667-1|AAA52148.1| 256|Homo sapiens steroid 11-beta-hydroxylase
protein.
Length = 256
Score = 84.6 bits (200), Expect = 6e-16
Identities = 72/255 (28%), Positives = 118/255 (46%), Gaps = 26/255 (10%)
Query: 171 AENSPEKKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSKYFINKAM 230
A +S + + +F + QL F P +++P K + F+ + + +Y N
Sbjct: 5 APSSASLNFLHAMEVMFKSTVQLMFMPRSLSRWTSPKVWK--EHFEAWDCIFQYGDNCIQ 62
Query: 231 RNINKNEN-KPDEQKGVLEKLLDINEEYA--YIMATDM-LVAG-VDTVANSIAATLYLFA 285
+ + N +P + ++ +LL +N E + I A M L AG VD + TL+ A
Sbjct: 63 KIYQELANSRPQQYTSIVAELL-LNAELSPDAIKANCMELTAGSVDRTVFPLLMTLFELA 121
Query: 286 KNPEKQEKLREEVMSKESK------------RYLKACIKETMRMMPVVSGNLRRTTKEYN 333
+NP Q+ LR+E ++ + L+A +KET+R+ PV R + +
Sbjct: 122 RNPNVQQPLRQESLAPAASISEHPQKATTELPLLRAALKETLRLYPVGLILERVVSSDLV 181
Query: 334 ILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGF 393
+ YH+P G V L +PRP + P+RWL K G F PFGF
Sbjct: 182 LQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIK------GSGRNFYHVPFGF 235
Query: 394 GVRSCIGRRIAELEI 408
G+R C+GRR+AE ++
Sbjct: 236 GMRQCLGRRLAEADM 250
>X12387-1|CAA30944.1| 503|Homo sapiens protein ( Human mRNA for
cytochrome P-450 (cyp3 locus). ).
Length = 503
Score = 83.8 bits (198), Expect = 1e-15
Identities = 60/222 (27%), Positives = 104/222 (46%), Gaps = 24/222 (10%)
Query: 210 KAMKMFQLQEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIMATDMLVAG 269
K MK +L ED K+ ++ I+ +K E L L + + +I A G
Sbjct: 254 KRMKESRL-EDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA------G 306
Query: 270 VDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIKETMRM 317
+T ++ ++ +Y A +P+ Q+KL+EE+ + + YL + ET+R+
Sbjct: 307 YETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL 366
Query: 318 MPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDP 377
P+ R K+ I G +PKG V L +++ P +F+PER+ D
Sbjct: 367 FPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDN 426
Query: 378 LYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
+ P++ PFG G R+CIG R A + ++ L ++L+NF
Sbjct: 427 I-----DPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>M14096-1|AAA35744.1| 503|Homo sapiens protein ( Human cytochrome
P-450 nifedipine oxidase mRNA, complet cds. ).
Length = 503
Score = 82.6 bits (195), Expect = 3e-15
Identities = 60/222 (27%), Positives = 103/222 (46%), Gaps = 24/222 (10%)
Query: 210 KAMKMFQLQEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIMATDMLVAG 269
K MK +L ED K+ ++ I+ +K E L L + + +I A G
Sbjct: 254 KRMKESRL-EDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA------G 306
Query: 270 VDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIKETMRM 317
+T ++ ++ +Y A +P+ Q+KL+EE+ + + YL + ET+R+
Sbjct: 307 YETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL 366
Query: 318 MPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDP 377
P+ R K+ I G +PKG V L +++ P +F+PER+ D
Sbjct: 367 FPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDN 426
Query: 378 LYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
+ P+ PFG G R+CIG R A + ++ L ++L+NF
Sbjct: 427 I-----DPYTYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>J04449-1|AAA35747.1| 502|Homo sapiens cytochrome P450 nifedipine
oxidase protein.
Length = 502
Score = 82.6 bits (195), Expect = 3e-15
Identities = 60/222 (27%), Positives = 103/222 (46%), Gaps = 24/222 (10%)
Query: 210 KAMKMFQLQEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIMATDMLVAG 269
K MK +L ED K+ ++ I+ +K E L L + + +I A G
Sbjct: 253 KRMKESRL-EDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA------G 305
Query: 270 VDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIKETMRM 317
+T ++ ++ +Y A +P+ Q+KL+EE+ + + YL + ET+R+
Sbjct: 306 YETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL 365
Query: 318 MPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDP 377
P+ R K+ I G +PKG V L +++ P +F+PER+ D
Sbjct: 366 FPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDN 425
Query: 378 LYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
+ P+ PFG G R+CIG R A + ++ L ++L+NF
Sbjct: 426 I-----DPYTYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 462
>M13785-1|AAA35742.1| 504|Homo sapiens protein ( Human liver
glucocorticoid-inducible cytochrome P-450 (HLp) mRNA,
complete cds. ).
Length = 504
Score = 82.2 bits (194), Expect = 3e-15
Identities = 61/223 (27%), Positives = 106/223 (47%), Gaps = 25/223 (11%)
Query: 210 KAMKMFQLQEDLSKYFINKAMRNINKNEN-KPDEQKGVLEKLLDINEEYAYIMATDMLVA 268
K MK +L ED K+ ++ I+ ++N K E L L + + +I A
Sbjct: 254 KRMKESRL-EDTQKHRVDFLQLMIDSHKNSKETESHKALSDLELVAQSIIFIFA------ 306
Query: 269 GVDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIKETMR 316
G +T ++ ++ +Y A +P+ Q+KL+EE+ + + YL + ET+R
Sbjct: 307 GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLR 366
Query: 317 MMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKND 376
+ P+ R K+ I G +PKG V L +++ P +F+PER+ D
Sbjct: 367 LFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKD 426
Query: 377 PLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
+ P++ PFG G R+CIG R A + ++ L ++L+NF
Sbjct: 427 NI-----DPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 464
>D00003-1|BAA00001.1| 504|Homo sapiens cytochrome P-450 protein.
Length = 504
Score = 82.2 bits (194), Expect = 3e-15
Identities = 61/223 (27%), Positives = 106/223 (47%), Gaps = 25/223 (11%)
Query: 210 KAMKMFQLQEDLSKYFINKAMRNINKNEN-KPDEQKGVLEKLLDINEEYAYIMATDMLVA 268
K MK +L ED K+ ++ I+ ++N K E L L + + +I A
Sbjct: 254 KRMKESRL-EDTQKHRVDFLQLMIDSHKNSKETESHKALSDLELVAQSIIFIFA------ 306
Query: 269 GVDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIKETMR 316
G +T ++ ++ +Y A +P+ Q+KL+EE+ + + YL + ET+R
Sbjct: 307 GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLR 366
Query: 317 MMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKND 376
+ P+ R K+ I G +PKG V L +++ P +F+PER+ D
Sbjct: 367 LFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKD 426
Query: 377 PLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
+ P++ PFG G R+CIG R A + ++ L ++L+NF
Sbjct: 427 NI-----DPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 464
>J04813-1|AAA02993.1| 502|Homo sapiens cytochrome P450 PCN3
protein.
Length = 502
Score = 81.4 bits (192), Expect = 6e-15
Identities = 51/166 (30%), Positives = 85/166 (51%), Gaps = 18/166 (10%)
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIKE 313
+ AG +T ++ ++ TLY A +P+ Q+KL++E+ + + YL + E
Sbjct: 303 IFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNE 362
Query: 314 TMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLAD 373
T+R+ PV R K+ I G +PKG V L +++ P EF PER+ +
Sbjct: 363 TLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF-SK 421
Query: 374 KNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
K D + P++ PFG G R+CIG R A + ++ L ++L+NF
Sbjct: 422 KKDSI-----DPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462
>BC033862-1|AAH33862.1| 502|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 5 protein.
Length = 502
Score = 81.4 bits (192), Expect = 6e-15
Identities = 51/166 (30%), Positives = 85/166 (51%), Gaps = 18/166 (10%)
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIKE 313
+ AG +T ++ ++ TLY A +P+ Q+KL++E+ + + YL + E
Sbjct: 303 IFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNE 362
Query: 314 TMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLAD 373
T+R+ PV R K+ I G +PKG V L +++ P EF PER+ +
Sbjct: 363 TLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF-SK 421
Query: 374 KNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
K D + P++ PFG G R+CIG R A + ++ L ++L+NF
Sbjct: 422 KKDSI-----DPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462
>AK223008-1|BAD96728.1| 502|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 5 variant protein.
Length = 502
Score = 81.4 bits (192), Expect = 6e-15
Identities = 51/166 (30%), Positives = 85/166 (51%), Gaps = 18/166 (10%)
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIKE 313
+ AG +T ++ ++ TLY A +P+ Q+KL++E+ + + YL + E
Sbjct: 303 IFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNE 362
Query: 314 TMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLAD 373
T+R+ PV R K+ I G +PKG V L +++ P EF PER+ +
Sbjct: 363 TLRLFPVAIRLERTCMKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF-SK 421
Query: 374 KNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
K D + P++ PFG G R+CIG R A + ++ L ++L+NF
Sbjct: 422 KKDSI-----DPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462
>AC005020-1|AAS02016.1| 502|Homo sapiens unknown protein.
Length = 502
Score = 81.4 bits (192), Expect = 6e-15
Identities = 51/166 (30%), Positives = 85/166 (51%), Gaps = 18/166 (10%)
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIKE 313
+ AG +T ++ ++ TLY A +P+ Q+KL++E+ + + YL + E
Sbjct: 303 IFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNE 362
Query: 314 TMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLAD 373
T+R+ PV R K+ I G +PKG V L +++ P EF PER+ +
Sbjct: 363 TLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF-SK 421
Query: 374 KNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
K D + P++ PFG G R+CIG R A + ++ L ++L+NF
Sbjct: 422 KKDSI-----DPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462
>BC132767-1|AAI32768.1| 544|Homo sapiens cytochrome P450, family 2,
subfamily U, polypeptide 1 protein.
Length = 544
Score = 80.6 bits (190), Expect = 1e-14
Identities = 52/179 (29%), Positives = 86/179 (48%), Gaps = 18/179 (10%)
Query: 254 NEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSK 301
+EEY + + D+ +AG DT NS+ L + NP+ QEK+ EE+ K
Sbjct: 338 DEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDK 397
Query: 302 ESKRYLKACIKETMRMMPVVSGNLRRTTKEYNIL-GYHVPKGIDVAFAHQDLSSMEEHYP 360
Y +A I E R+ VV + T E +L GY +PKG + + +
Sbjct: 398 AQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWE 457
Query: 361 RPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
+P +F P R+L D+ + K F+ PFG G R C+G ++A++E+ ++++F
Sbjct: 458 KPEDFYPNRFLDDQGQLI---KKETFI--PFGIGKRVCMGEQLAKMELFLMFVSLMQSF 511
>AY343323-1|AAQ21380.1| 544|Homo sapiens cytochrome P450 protein.
Length = 544
Score = 80.6 bits (190), Expect = 1e-14
Identities = 52/179 (29%), Positives = 86/179 (48%), Gaps = 18/179 (10%)
Query: 254 NEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSK 301
+EEY + + D+ +AG DT NS+ L + NP+ QEK+ EE+ K
Sbjct: 338 DEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDK 397
Query: 302 ESKRYLKACIKETMRMMPVVSGNLRRTTKEYNIL-GYHVPKGIDVAFAHQDLSSMEEHYP 360
Y +A I E R+ VV + T E +L GY +PKG + + +
Sbjct: 398 AQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWE 457
Query: 361 RPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
+P +F P R+L D+ + K F+ PFG G R C+G ++A++E+ ++++F
Sbjct: 458 KPEDFYPNRFLDDQGQLI---KKETFI--PFGIGKRVCMGEQLAKMELFLMFVSLMQSF 511
>AL358613-3|CAH72804.1| 428|Homo sapiens cytochrome P450, family
26, subfamily A, polypeptide 1 protein.
Length = 428
Score = 79.8 bits (188), Expect = 2e-14
Identities = 50/184 (27%), Positives = 88/184 (47%), Gaps = 22/184 (11%)
Query: 262 ATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEVMSK-----------------ESK 304
+T++L G +T A++ + + P +K+REE+ SK E
Sbjct: 225 STELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQL 284
Query: 305 RYLKACIKETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTE 364
+Y+ IKET+R+ P V G R K + + GY +PKG +V ++ D + E + E
Sbjct: 285 KYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEE 344
Query: 365 FIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWY 424
F P+R++ + A F PFG G+RSC+G+ A++ ++ F ++ + +
Sbjct: 345 FNPDRFMLPHPE-----DASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLL 399
Query: 425 GPPP 428
PP
Sbjct: 400 NGPP 403
>AL358613-2|CAH72803.1| 497|Homo sapiens cytochrome P450, family
26, subfamily A, polypeptide 1 protein.
Length = 497
Score = 79.8 bits (188), Expect = 2e-14
Identities = 50/184 (27%), Positives = 88/184 (47%), Gaps = 22/184 (11%)
Query: 262 ATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEVMSK-----------------ESK 304
+T++L G +T A++ + + P +K+REE+ SK E
Sbjct: 294 STELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQL 353
Query: 305 RYLKACIKETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTE 364
+Y+ IKET+R+ P V G R K + + GY +PKG +V ++ D + E + E
Sbjct: 354 KYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEE 413
Query: 365 FIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWY 424
F P+R++ + A F PFG G+RSC+G+ A++ ++ F ++ + +
Sbjct: 414 FNPDRFMLPHPE-----DASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLL 468
Query: 425 GPPP 428
PP
Sbjct: 469 NGPP 472
>AF005418-1|AAB88881.1| 497|Homo sapiens retinoic acid hydroxylase
protein.
Length = 497
Score = 79.8 bits (188), Expect = 2e-14
Identities = 50/184 (27%), Positives = 88/184 (47%), Gaps = 22/184 (11%)
Query: 262 ATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEVMSK-----------------ESK 304
+T++L G +T A++ + + P +K+REE+ SK E
Sbjct: 294 STELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQL 353
Query: 305 RYLKACIKETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTE 364
+Y+ IKET+R+ P V G R K + + GY +PKG +V ++ D + E + E
Sbjct: 354 KYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEE 413
Query: 365 FIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWY 424
F P+R++ + A F PFG G+RSC+G+ A++ ++ F ++ + +
Sbjct: 414 FNPDRFMLPHPE-----DASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLL 468
Query: 425 GPPP 428
PP
Sbjct: 469 NGPP 472
>Y07508-1|CAA68807.1| 503|Homo sapiens protein ( Human mRNA for
aromatase P-450. ).
Length = 503
Score = 79.0 bits (186), Expect = 3e-14
Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 27/263 (10%)
Query: 176 EKKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSKYFINKAMRNINK 235
E ++ + F+ L +P ++ S YKK K + +D + I + R I+
Sbjct: 210 ESAIVVKIQGYFDAWQALLIKPDIFFKISW-LYKKYEKSVKDLKDAIEVLIAEKRRRIST 268
Query: 236 NENKPDEQKGVLEKLL-----DINEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEK 290
E + E +L D+ E +ML+A DT++ S+ L+L AK+P
Sbjct: 269 EEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNV 328
Query: 291 QEKLREEVMSKESKRYLKA-----------CIKETMRMMPVVSGNLRRTTKEYNILGYHV 339
+E + +E+ + +R +K I E+MR PVV +R+ ++ I GY V
Sbjct: 329 EEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPV 388
Query: 340 PKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCI 399
KG ++ + + E +P+P EF E + KN P Y PFGFG R C
Sbjct: 389 KKGTNIILNIGRMHRL-EFFPKPNEFTLENFA--KNVPYRY-------FQPFGFGPRGCA 438
Query: 400 GRRIAELEIETFLTKILENFRVE 422
G+ IA + ++ L +L F V+
Sbjct: 439 GKYIAMVMMKAILVTLLRRFHVK 461
>X13589-1|CAA31929.1| 503|Homo sapiens protein ( Human mRNA for
aromatase (estrogen synthetase). ).
Length = 503
Score = 79.0 bits (186), Expect = 3e-14
Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 27/263 (10%)
Query: 176 EKKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSKYFINKAMRNINK 235
E ++ + F+ L +P ++ S YKK K + +D + I + R I+
Sbjct: 210 ESAIVVKIQGYFDAWQALLIKPDIFFKISW-LYKKYEKSVKDLKDAIEVLIAEKRRRIST 268
Query: 236 NENKPDEQKGVLEKLL-----DINEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEK 290
E + E +L D+ E +ML+A DT++ S+ L+L AK+P
Sbjct: 269 EEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNV 328
Query: 291 QEKLREEVMSKESKRYLKA-----------CIKETMRMMPVVSGNLRRTTKEYNILGYHV 339
+E + +E+ + +R +K I E+MR PVV +R+ ++ I GY V
Sbjct: 329 EEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPV 388
Query: 340 PKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCI 399
KG ++ + + E +P+P EF E + KN P Y PFGFG R C
Sbjct: 389 KKGTNIILNIGRMHRL-EFFPKPNEFTLENFA--KNVPYRY-------FQPFGFGPRGCA 438
Query: 400 GRRIAELEIETFLTKILENFRVE 422
G+ IA + ++ L +L F V+
Sbjct: 439 GKYIAMVMMKAILVTLLRRFHVK 461
>M30804-1|AAA35728.1| 503|Homo sapiens protein ( Human aromatase
cytochrome P-450 gene, exon 10. ).
Length = 503
Score = 79.0 bits (186), Expect = 3e-14
Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 27/263 (10%)
Query: 176 EKKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSKYFINKAMRNINK 235
E ++ + F+ L +P ++ S YKK K + +D + I + R I+
Sbjct: 210 ESAIVVKIQGYFDAWQALLIKPDIFFKISW-LYKKYEKSVKDLKDAIEVLIAEKRRRIST 268
Query: 236 NENKPDEQKGVLEKLL-----DINEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEK 290
E + E +L D+ E +ML+A DT++ S+ L+L AK+P
Sbjct: 269 EEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNV 328
Query: 291 QEKLREEVMSKESKRYLKA-----------CIKETMRMMPVVSGNLRRTTKEYNILGYHV 339
+E + +E+ + +R +K I E+MR PVV +R+ ++ I GY V
Sbjct: 329 EEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPV 388
Query: 340 PKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCI 399
KG ++ + + E +P+P EF E + KN P Y PFGFG R C
Sbjct: 389 KKGTNIILNIGRMHRL-EFFPKPNEFTLENFA--KNVPYRY-------FQPFGFGPRGCA 438
Query: 400 GRRIAELEIETFLTKILENFRVE 422
G+ IA + ++ L +L F V+
Sbjct: 439 GKYIAMVMMKAILVTLLRRFHVK 461
>M22246-1|AAA35557.1| 503|Homo sapiens protein ( Human aromatase
mRNA, complete cds. ).
Length = 503
Score = 79.0 bits (186), Expect = 3e-14
Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 27/263 (10%)
Query: 176 EKKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSKYFINKAMRNINK 235
E ++ + F+ L +P ++ S YKK K + +D + I + R I+
Sbjct: 210 ESAIVVKIQGYFDAWQALLIKPDIFFKISW-LYKKYEKSVKDLKDAIEVLIAEKRRRIST 268
Query: 236 NENKPDEQKGVLEKLL-----DINEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEK 290
E + E +L D+ E +ML+A DT++ S+ L+L AK+P
Sbjct: 269 EEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNV 328
Query: 291 QEKLREEVMSKESKRYLKA-----------CIKETMRMMPVVSGNLRRTTKEYNILGYHV 339
+E + +E+ + +R +K I E+MR PVV +R+ ++ I GY V
Sbjct: 329 EEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPV 388
Query: 340 PKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCI 399
KG ++ + + E +P+P EF E + KN P Y PFGFG R C
Sbjct: 389 KKGTNIILNIGRMHRL-EFFPKPNEFTLENFA--KNVPYRY-------FQPFGFGPRGCA 438
Query: 400 GRRIAELEIETFLTKILENFRVE 422
G+ IA + ++ L +L F V+
Sbjct: 439 GKYIAMVMMKAILVTLLRRFHVK 461
>M18856-1|AAA35556.1| 419|Homo sapiens protein ( Human aromatase
(Aro1) mRNA, complete cds. ).
Length = 419
Score = 79.0 bits (186), Expect = 3e-14
Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 27/263 (10%)
Query: 176 EKKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSKYFINKAMRNINK 235
E ++ + F+ L +P ++ S YKK K + +D + I + R I+
Sbjct: 126 ESAIVVKIQGYFDAWQALLIKPDIFFKISW-LYKKYEKSVKDLKDAIEVLIAEKRRRIST 184
Query: 236 NENKPDEQKGVLEKLL-----DINEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEK 290
E + E +L D+ E +ML+A DT++ S+ L+L AK+P
Sbjct: 185 EEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNV 244
Query: 291 QEKLREEVMSKESKRYLKA-----------CIKETMRMMPVVSGNLRRTTKEYNILGYHV 339
+E + +E+ + +R +K I E+MR PVV +R+ ++ I GY V
Sbjct: 245 EEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPV 304
Query: 340 PKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCI 399
KG ++ + + E +P+P EF E + KN P Y PFGFG R C
Sbjct: 305 KKGTNIILNIGRMHRL-EFFPKPNEFTLENFA--KNVPYRY-------FQPFGFGPRGCA 354
Query: 400 GRRIAELEIETFLTKILENFRVE 422
G+ IA + ++ L +L F V+
Sbjct: 355 GKYIAMVMMKAILVTLLRRFHVK 377
>D00408-1|BAA00310.1| 503|Homo sapiens cytochrome P-450 HFLa
protein.
Length = 503
Score = 79.0 bits (186), Expect = 3e-14
Identities = 46/166 (27%), Positives = 84/166 (50%), Gaps = 17/166 (10%)
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIKE 313
+ AG +T ++ ++ +Y A +P+ Q+K+++E+ + + YL + E
Sbjct: 303 IFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNE 362
Query: 314 TMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLAD 373
T+R+ PV R K+ I G +PKG+ V L +++ P +F+PER+
Sbjct: 363 TLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKK 422
Query: 374 KNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
D + P++ PFG G R+CIG R A + ++ L ++L+NF
Sbjct: 423 NKDNI-----DPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNF 463
>DQ118405-1|AAZ23558.1| 503|Homo sapiens cytochrome P450 subfamily
19 subfamily A polypeptide 1 protein.
Length = 503
Score = 79.0 bits (186), Expect = 3e-14
Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 27/263 (10%)
Query: 176 EKKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSKYFINKAMRNINK 235
E ++ + F+ L +P ++ S YKK K + +D + I + R I+
Sbjct: 210 ESAIVVKIQGYFDAWQALLIKPDIFFKISW-LYKKYEKSVKDLKDAIEVLIAEKRRRIST 268
Query: 236 NENKPDEQKGVLEKLL-----DINEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEK 290
E + E +L D+ E +ML+A DT++ S+ L+L AK+P
Sbjct: 269 EEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNV 328
Query: 291 QEKLREEVMSKESKRYLKA-----------CIKETMRMMPVVSGNLRRTTKEYNILGYHV 339
+E + +E+ + +R +K I E+MR PVV +R+ ++ I GY V
Sbjct: 329 EEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPV 388
Query: 340 PKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCI 399
KG ++ + + E +P+P EF E + KN P Y PFGFG R C
Sbjct: 389 KKGTNIILNIGRMHRL-EFFPKPNEFTLENFA--KNVPYRY-------FQPFGFGPRGCA 438
Query: 400 GRRIAELEIETFLTKILENFRVE 422
G+ IA + ++ L +L F V+
Sbjct: 439 GKYIAMVMMKAILVTLLRRFHVK 461
>BC107785-1|AAI07786.1| 503|Homo sapiens cytochrome P450, family
19, subfamily A, polypeptide 1 protein.
Length = 503
Score = 79.0 bits (186), Expect = 3e-14
Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 27/263 (10%)
Query: 176 EKKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSKYFINKAMRNINK 235
E ++ + F+ L +P ++ S YKK K + +D + I + R I+
Sbjct: 210 ESAIVVKIQGYFDAWQALLIKPDIFFKISW-LYKKYEKSVKDLKDAIEVLIAEKRRRIST 268
Query: 236 NENKPDEQKGVLEKLL-----DINEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEK 290
E + E +L D+ E +ML+A DT++ S+ L+L AK+P
Sbjct: 269 EEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNV 328
Query: 291 QEKLREEVMSKESKRYLKA-----------CIKETMRMMPVVSGNLRRTTKEYNILGYHV 339
+E + +E+ + +R +K I E+MR PVV +R+ ++ I GY V
Sbjct: 329 EEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPV 388
Query: 340 PKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCI 399
KG ++ + + E +P+P EF E + KN P Y PFGFG R C
Sbjct: 389 KKGTNIILNIGRMHRL-EFFPKPNEFTLENFA--KNVPYRY-------FQPFGFGPRGCA 438
Query: 400 GRRIAELEIETFLTKILENFRVE 422
G+ IA + ++ L +L F V+
Sbjct: 439 GKYIAMVMMKAILVTLLRRFHVK 461
>BC067436-1|AAH67436.1| 503|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 7 protein.
Length = 503
Score = 79.0 bits (186), Expect = 3e-14
Identities = 46/166 (27%), Positives = 84/166 (50%), Gaps = 17/166 (10%)
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIKE 313
+ AG +T ++ ++ +Y A +P+ Q+K+++E+ + + YL + E
Sbjct: 303 IFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNE 362
Query: 314 TMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLAD 373
T+R+ PV R K+ I G +PKG+ V L +++ P +F+PER+
Sbjct: 363 TLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKK 422
Query: 374 KNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
D + P++ PFG G R+CIG R A + ++ L ++L+NF
Sbjct: 423 NKDNI-----DPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNF 463
>BC035959-1|AAH35959.1| 503|Homo sapiens cytochrome P450, family
19, subfamily A, polypeptide 1 protein.
Length = 503
Score = 79.0 bits (186), Expect = 3e-14
Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 27/263 (10%)
Query: 176 EKKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSKYFINKAMRNINK 235
E ++ + F+ L +P ++ S YKK K + +D + I + R I+
Sbjct: 210 ESAIVVKIQGYFDAWQALLIKPDIFFKISW-LYKKYEKSVKDLKDAIEVLIAEKRRRIST 268
Query: 236 NENKPDEQKGVLEKLL-----DINEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEK 290
E + E +L D+ E +ML+A DT++ S+ L+L AK+P
Sbjct: 269 EEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNV 328
Query: 291 QEKLREEVMSKESKRYLKA-----------CIKETMRMMPVVSGNLRRTTKEYNILGYHV 339
+E + +E+ + +R +K I E+MR PVV +R+ ++ I GY V
Sbjct: 329 EEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPV 388
Query: 340 PKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCI 399
KG ++ + + E +P+P EF E + KN P Y PFGFG R C
Sbjct: 389 KKGTNIILNIGRMHRL-EFFPKPNEFTLENFA--KNVPYRY-------FQPFGFGPRGCA 438
Query: 400 GRRIAELEIETFLTKILENFRVE 422
G+ IA + ++ L +L F V+
Sbjct: 439 GKYIAMVMMKAILVTLLRRFHVK 461
>AY957953-1|AAX44046.1| 503|Homo sapiens cytochrome P450, family
19, subfamily A, polypeptide 1 protein.
Length = 503
Score = 79.0 bits (186), Expect = 3e-14
Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 27/263 (10%)
Query: 176 EKKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSKYFINKAMRNINK 235
E ++ + F+ L +P ++ S YKK K + +D + I + R I+
Sbjct: 210 ESAIVVKIQGYFDAWQALLIKPDIFFKISW-LYKKYEKSVKDLKDAIEVLIAEKRRRIST 268
Query: 236 NENKPDEQKGVLEKLL-----DINEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEK 290
E + E +L D+ E +ML+A DT++ S+ L+L AK+P
Sbjct: 269 EEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNV 328
Query: 291 QEKLREEVMSKESKRYLKA-----------CIKETMRMMPVVSGNLRRTTKEYNILGYHV 339
+E + +E+ + +R +K I E+MR PVV +R+ ++ I GY V
Sbjct: 329 EEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPV 388
Query: 340 PKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCI 399
KG ++ + + E +P+P EF E + KN P Y PFGFG R C
Sbjct: 389 KKGTNIILNIGRMHRL-EFFPKPNEFTLENFA--KNVPYRY-------FQPFGFGPRGCA 438
Query: 400 GRRIAELEIETFLTKILENFRVE 422
G+ IA + ++ L +L F V+
Sbjct: 439 GKYIAMVMMKAILVTLLRRFHVK 461
>AF315325-1|AAG48618.1| 535|Homo sapiens cytochrome P450 variant
3A7 protein.
Length = 535
Score = 79.0 bits (186), Expect = 3e-14
Identities = 46/166 (27%), Positives = 84/166 (50%), Gaps = 17/166 (10%)
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIKE 313
+ AG +T ++ ++ +Y A +P+ Q+K+++E+ + + YL + E
Sbjct: 303 IFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNE 362
Query: 314 TMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLAD 373
T+R+ PV R K+ I G +PKG+ V L +++ P +F+PER+
Sbjct: 363 TLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKK 422
Query: 374 KNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
D + P++ PFG G R+CIG R A + ++ L ++L+NF
Sbjct: 423 NKDNI-----DPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNF 463
>AF280107-3|AAG32289.1| 503|Homo sapiens cytochrome P450
polypeptide 7 protein.
Length = 503
Score = 79.0 bits (186), Expect = 3e-14
Identities = 46/166 (27%), Positives = 84/166 (50%), Gaps = 17/166 (10%)
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIKE 313
+ AG +T ++ ++ +Y A +P+ Q+K+++E+ + + YL + E
Sbjct: 303 IFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNE 362
Query: 314 TMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLAD 373
T+R+ PV R K+ I G +PKG+ V L +++ P +F+PER+
Sbjct: 363 TLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKK 422
Query: 374 KNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
D + P++ PFG G R+CIG R A + ++ L ++L+NF
Sbjct: 423 NKDNI-----DPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNF 463
>AL358613-1|CAH72802.2| 522|Homo sapiens cytochrome P450, family
26, subfamily C, polypeptide 1 protein.
Length = 522
Score = 77.0 bits (181), Expect = 1e-13
Identities = 42/130 (32%), Positives = 67/130 (51%), Gaps = 3/130 (2%)
Query: 305 RYLKACIKETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTE 364
RY+ +KE +R++P VSG R + + + GY +PKG V ++ +D Y P E
Sbjct: 367 RYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSVMYSIRDTHETAAVYRSPPE 426
Query: 365 -FIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEW 423
F PER+ A + D G + F PFG G RSC+G+ +A+ ++ +++ R E
Sbjct: 427 GFDPERFGAAREDS--RGASSRFHYIPFGGGARSCLGQELAQAVLQLLAVELVRTARWEL 484
Query: 424 YGPPPKIIQT 433
P +QT
Sbjct: 485 ATPAFPAMQT 494
>M28420-1|AAA52141.1| 419|Homo sapiens cytochrome P-450 aromatase
protein.
Length = 419
Score = 75.8 bits (178), Expect = 3e-13
Identities = 70/263 (26%), Positives = 117/263 (44%), Gaps = 27/263 (10%)
Query: 176 EKKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSKYFINKAMRNINK 235
E ++ + F+ L +P ++ S YKK K + +D + I + I+
Sbjct: 126 ESAIVVKIQGYFDAWQALLIKPDIFFKISW-LYKKYEKSVKDLKDAIEVLIAEKRCRIST 184
Query: 236 NENKPDEQKGVLEKLL-----DINEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEK 290
E + E +L D+ E +ML+A DT++ S+ L+L AK+P
Sbjct: 185 EEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNV 244
Query: 291 QEKLREEVMSKESKRYLKA-----------CIKETMRMMPVVSGNLRRTTKEYNILGYHV 339
+E + +E+ + +R +K I E+MR PVV +R+ ++ I GY V
Sbjct: 245 EEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPV 304
Query: 340 PKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCI 399
KG ++ + + E +P+P EF E + KN P Y PFGFG R C
Sbjct: 305 KKGTNIILNIGRMHRL-EFFPKPNEFTLENFA--KNVPYRY-------FQPFGFGPRGCA 354
Query: 400 GRRIAELEIETFLTKILENFRVE 422
G+ IA + ++ L +L F V+
Sbjct: 355 GKYIAMVMMKAILVTLLRRFHVK 377
>J04127-1|AAA52132.1| 503|Homo sapiens CYP19 protein.
Length = 503
Score = 75.8 bits (178), Expect = 3e-13
Identities = 70/263 (26%), Positives = 117/263 (44%), Gaps = 27/263 (10%)
Query: 176 EKKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSKYFINKAMRNINK 235
E ++ + F+ L +P ++ S YKK K + +D + I + I+
Sbjct: 210 ESAIVVKIQGYFDAWQALLIKPDIFFKISW-LYKKYEKSVKDLKDAIEVLIAEKRCRIST 268
Query: 236 NENKPDEQKGVLEKLL-----DINEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEK 290
E + E +L D+ E +ML+A DT++ S+ L+L AK+P
Sbjct: 269 EEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNV 328
Query: 291 QEKLREEVMSKESKRYLKA-----------CIKETMRMMPVVSGNLRRTTKEYNILGYHV 339
+E + +E+ + +R +K I E+MR PVV +R+ ++ I GY V
Sbjct: 329 EEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPV 388
Query: 340 PKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCI 399
KG ++ + + E +P+P EF E + KN P Y PFGFG R C
Sbjct: 389 KKGTNIILNIGRMHRL-EFFPKPNEFTLENFA--KNVPYRY-------FQPFGFGPRGCA 438
Query: 400 GRRIAELEIETFLTKILENFRVE 422
G+ IA + ++ L +L F V+
Sbjct: 439 GKYIAMVMMKAILVTLLRRFHVK 461
>BC067429-1|AAH67429.1| 516|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 2 protein.
Length = 516
Score = 75.8 bits (178), Expect = 3e-13
Identities = 84/295 (28%), Positives = 137/295 (46%), Gaps = 29/295 (9%)
Query: 157 VAFGIRLNCFDPNLAENSPEK-KLIECVHQIFNLS---NQLDFQPSLWHIFSTPTYK-KA 211
VA I CF + E+S E L++ H+ + N LDF P L ++ + + KA
Sbjct: 196 VANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKA 255
Query: 212 MK---MFQLQEDLSKY---FINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIMATDM 265
++ LQ+ + ++ F ++R+I K +KG I +E + D+
Sbjct: 256 FNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFK-HSKKGPRASGNLIPQEKIVNLVNDI 314
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREE---VMSKESK---------RYLKACIKE 313
AG DTV +I+ +L PE Q K+++E V+ +E + YL+A I E
Sbjct: 315 FGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILE 374
Query: 314 TMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
T R P + + TT++ + G+++PK V ++ E + P+EF PER+L
Sbjct: 375 TFRHSPFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPP 427
D K M FG G R CIG +A+ EI FL +L+ ++E+ PP
Sbjct: 435 --ADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ--QLEFSVPP 485
>AY390424-1|AAQ92352.1| 503|Homo sapiens cytochrome P450 CYP3A43.3
protein.
Length = 503
Score = 75.8 bits (178), Expect = 3e-13
Identities = 49/167 (29%), Positives = 83/167 (49%), Gaps = 17/167 (10%)
Query: 265 MLVAGVDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIK 312
++ A DT + ++ +Y A +P+ Q+KL+EE+ + + + YL +
Sbjct: 302 IIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLANKAPVTYDALVQMEYLDMVVN 361
Query: 313 ETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
ET+R+ PVVS R K+ I G +PKG+ V L +++ P +F PER+
Sbjct: 362 ETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSK 421
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
D + + ++ PFG G R+CIG R A I+ + + L+NF
Sbjct: 422 KNKDSI---DLYRYI--PFGAGPRNCIGMRFALTNIKLAVIRALQNF 463
>X58906-1|CAA41709.1| 495|Homo sapiens steroid 21-monooxygenase
protein.
Length = 495
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/181 (32%), Positives = 91/181 (50%), Gaps = 25/181 (13%)
Query: 255 EEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE-------------VMSK 301
E + ++ A D+L+ G +T AN+++ + +PE Q++L+EE V K
Sbjct: 279 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYK 338
Query: 302 ESKRY--LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEH 358
+ R L A I E +R+ PVV L RTT+ +I GY +P+G + Q E
Sbjct: 339 DHARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETV 398
Query: 359 YPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILEN 418
+ RP EF P+R+L +P +A FG G R C+G +A LE+ LT++L+
Sbjct: 399 WERPHEFWPDRFL----EPGKNSRA-----LAFGCGARVCLGEPLARLELFVVLTRLLQA 449
Query: 419 F 419
F
Sbjct: 450 F 450
>M28548-1|AAA52065.1| 495|Homo sapiens protein ( Human mutant
21-hydroxylase B gene, complete cds. ).
Length = 495
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/181 (32%), Positives = 91/181 (50%), Gaps = 25/181 (13%)
Query: 255 EEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE-------------VMSK 301
E + ++ A D+L+ G +T AN+++ + +PE Q++L+EE V K
Sbjct: 279 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYK 338
Query: 302 ESKRY--LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEH 358
+ R L A I E +R+ PVV L RTT+ +I GY +P+G + Q E
Sbjct: 339 DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETV 398
Query: 359 YPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILEN 418
+ RP EF P+R+L +P +A FG G R C+G +A LE+ LT++L+
Sbjct: 399 WERPHEFWPDRFL----EPGKNSRA-----LAFGCGARVCLGEPLARLELFVVLTRLLQA 449
Query: 419 F 419
F
Sbjct: 450 F 450
>M26856-1|AAA52064.1| 495|Homo sapiens protein ( Human
21-hydroxylase B gene, complete cds. ).
Length = 495
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/181 (32%), Positives = 91/181 (50%), Gaps = 25/181 (13%)
Query: 255 EEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE-------------VMSK 301
E + ++ A D+L+ G +T AN+++ + +PE Q++L+EE V K
Sbjct: 279 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYK 338
Query: 302 ESKRY--LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEH 358
+ R L A I E +R+ PVV L RTT+ +I GY +P+G + Q E
Sbjct: 339 DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETV 398
Query: 359 YPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILEN 418
+ RP EF P+R+L +P +A FG G R C+G +A LE+ LT++L+
Sbjct: 399 WERPHEFWPDRFL----EPGKNSRA-----LAFGCGARVCLGEPLARLELFVVLTRLLQA 449
Query: 419 F 419
F
Sbjct: 450 F 450
>M13936-1|AAA59695.1| 494|Homo sapiens CYP21P protein.
Length = 494
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/181 (32%), Positives = 91/181 (50%), Gaps = 25/181 (13%)
Query: 255 EEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE-------------VMSK 301
E + ++ A D+L+ G +T AN+++ + +PE Q++L+EE V K
Sbjct: 278 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYK 337
Query: 302 ESKRY--LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEH 358
+ R L A I E +R+ PVV L RTT+ +I GY +P+G + Q E
Sbjct: 338 DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETV 397
Query: 359 YPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILEN 418
+ RP EF P+R+L +P +A FG G R C+G +A LE+ LT++L+
Sbjct: 398 WERPHEFWPDRFL----EPGKNSRA-----LAFGCGARVCLGEPLARLELFVVLTRLLQA 448
Query: 419 F 419
F
Sbjct: 449 F 449
>BX679671-8|CAM26071.1| 464|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 464
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/181 (32%), Positives = 91/181 (50%), Gaps = 25/181 (13%)
Query: 255 EEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE-------------VMSK 301
E + ++ A D+L+ G +T AN+++ + +PE Q++L+EE V K
Sbjct: 248 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYK 307
Query: 302 ESKRY--LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEH 358
+ R L A I E +R+ PVV L RTT+ +I GY +P+G + Q E
Sbjct: 308 DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETV 367
Query: 359 YPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILEN 418
+ RP EF P+R+L +P +A FG G R C+G +A LE+ LT++L+
Sbjct: 368 WERPHEFWPDRFL----EPGKNSRA-----LAFGCGARVCLGEPLARLELFVVLTRLLQA 418
Query: 419 F 419
F
Sbjct: 419 F 419
>BX679671-7|CAM26070.1| 494|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 494
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/181 (32%), Positives = 91/181 (50%), Gaps = 25/181 (13%)
Query: 255 EEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE-------------VMSK 301
E + ++ A D+L+ G +T AN+++ + +PE Q++L+EE V K
Sbjct: 278 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYK 337
Query: 302 ESKRY--LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEH 358
+ R L A I E +R+ PVV L RTT+ +I GY +P+G + Q E
Sbjct: 338 DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETV 397
Query: 359 YPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILEN 418
+ RP EF P+R+L +P +A FG G R C+G +A LE+ LT++L+
Sbjct: 398 WERPHEFWPDRFL----EPGKNSRA-----LAFGCGARVCLGEPLARLELFVVLTRLLQA 448
Query: 419 F 419
F
Sbjct: 449 F 449
>BC125182-1|AAI25183.1| 494|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 494
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/181 (32%), Positives = 91/181 (50%), Gaps = 25/181 (13%)
Query: 255 EEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE-------------VMSK 301
E + ++ A D+L+ G +T AN+++ + +PE Q++L+EE V K
Sbjct: 278 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYK 337
Query: 302 ESKRY--LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEH 358
+ R L A I E +R+ PVV L RTT+ +I GY +P+G + Q E
Sbjct: 338 DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETV 397
Query: 359 YPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILEN 418
+ RP EF P+R+L +P +A FG G R C+G +A LE+ LT++L+
Sbjct: 398 WERPHEFWPDRFL----EPGKNSRA-----LAFGCGARVCLGEPLARLELFVVLTRLLQA 448
Query: 419 F 419
F
Sbjct: 449 F 449
>BC125181-1|AAI25182.1| 495|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 495
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/181 (32%), Positives = 91/181 (50%), Gaps = 25/181 (13%)
Query: 255 EEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE-------------VMSK 301
E + ++ A D+L+ G +T AN+++ + +PE Q++L+EE V K
Sbjct: 279 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYK 338
Query: 302 ESKRY--LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEH 358
+ R L A I E +R+ PVV L RTT+ +I GY +P+G + Q E
Sbjct: 339 DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETV 398
Query: 359 YPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILEN 418
+ RP EF P+R+L +P +A FG G R C+G +A LE+ LT++L+
Sbjct: 399 WERPHEFWPDRFL----EPGKNSRA-----LAFGCGARVCLGEPLARLELFVVLTRLLQA 449
Query: 419 F 419
F
Sbjct: 450 F 450
>AM183951-1|CAJ75805.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/181 (32%), Positives = 91/181 (50%), Gaps = 25/181 (13%)
Query: 255 EEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE-------------VMSK 301
E + ++ A D+L+ G +T AN+++ + +PE Q++L+EE V K
Sbjct: 278 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYK 337
Query: 302 ESKRY--LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEH 358
+ R L A I E +R+ PVV L RTT+ +I GY +P+G + Q E
Sbjct: 338 DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETV 397
Query: 359 YPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILEN 418
+ RP EF P+R+L +P +A FG G R C+G +A LE+ LT++L+
Sbjct: 398 WERPHEFWPDRFL----EPGKNSRA-----LAFGCGARVCLGEPLARLELFVVLTRLLQA 448
Query: 419 F 419
F
Sbjct: 449 F 449
>AM183949-1|CAJ75803.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 75.4 bits (177), Expect = 4e-13
Identities = 61/182 (33%), Positives = 95/182 (52%), Gaps = 27/182 (14%)
Query: 255 EEYAYIMATDMLVAGVDTVANSIA-ATLYLFAKNPEKQEKLREE-------------VMS 300
E + ++ A D+L+ G +T AN+++ A ++LF +PE Q++L+EE V
Sbjct: 278 EGHVHMAAVDLLIGGTETTANTLSWAVVFLF-HHPEIQQRLQEELDHELGPGASSSRVPY 336
Query: 301 KESKRY--LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEE 357
K+ R L A I E +R+ PVV L RTT+ +I GY +P+G + Q E
Sbjct: 337 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 396
Query: 358 HYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILE 417
+ RP EF P+R+L +P +A FG G R C+G +A LE+ LT++L+
Sbjct: 397 VWERPHEFWPDRFL----EPGKNSRA-----LAFGCGARVCLGEPLARLELFVVLTRLLQ 447
Query: 418 NF 419
F
Sbjct: 448 AF 449
>AM183947-1|CAJ75801.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/181 (32%), Positives = 91/181 (50%), Gaps = 25/181 (13%)
Query: 255 EEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE-------------VMSK 301
E + ++ A D+L+ G +T AN+++ + +PE Q++L+EE V K
Sbjct: 278 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYK 337
Query: 302 ESKRY--LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEH 358
+ R L A I E +R+ PVV L RTT+ +I GY +P+G + Q E
Sbjct: 338 DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETV 397
Query: 359 YPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILEN 418
+ RP EF P+R+L +P +A FG G R C+G +A LE+ LT++L+
Sbjct: 398 WERPHEFWPDRFL----EPGKNSRA-----LAFGCGARVCLGEPLARLELFVVLTRLLQA 448
Query: 419 F 419
F
Sbjct: 449 F 449
>AM183946-1|CAJ75800.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/181 (32%), Positives = 91/181 (50%), Gaps = 25/181 (13%)
Query: 255 EEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE-------------VMSK 301
E + ++ A D+L+ G +T AN+++ + +PE Q++L+EE V K
Sbjct: 278 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYK 337
Query: 302 ESKRY--LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEH 358
+ R L A I E +R+ PVV L RTT+ +I GY +P+G + Q E
Sbjct: 338 DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETV 397
Query: 359 YPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILEN 418
+ RP EF P+R+L +P +A FG G R C+G +A LE+ LT++L+
Sbjct: 398 WERPHEFWPDRFL----EPGKNSRA-----LAFGCGARVCLGEPLARLELFVVLTRLLQA 448
Query: 419 F 419
F
Sbjct: 449 F 449
>AM183945-1|CAJ75799.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/181 (32%), Positives = 91/181 (50%), Gaps = 25/181 (13%)
Query: 255 EEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE-------------VMSK 301
E + ++ A D+L+ G +T AN+++ + +PE Q++L+EE V K
Sbjct: 278 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYK 337
Query: 302 ESKRY--LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEH 358
+ R L A I E +R+ PVV L RTT+ +I GY +P+G + Q E
Sbjct: 338 DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETV 397
Query: 359 YPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILEN 418
+ RP EF P+R+L +P +A FG G R C+G +A LE+ LT++L+
Sbjct: 398 WERPHEFWPDRFL----EPGKNSRA-----LAFGCGARVCLGEPLARLELFVVLTRLLQA 448
Query: 419 F 419
F
Sbjct: 449 F 449
>AM086565-1|CAJ31104.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/181 (32%), Positives = 91/181 (50%), Gaps = 25/181 (13%)
Query: 255 EEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE-------------VMSK 301
E + ++ A D+L+ G +T AN+++ + +PE Q++L+EE V K
Sbjct: 278 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYK 337
Query: 302 ESKRY--LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEH 358
+ R L A I E +R+ PVV L RTT+ +I GY +P+G + Q E
Sbjct: 338 DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGTHLDETV 397
Query: 359 YPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILEN 418
+ RP EF P+R+L +P +A FG G R C+G +A LE+ LT++L+
Sbjct: 398 WERPHEFWPDRFL----EPGKNSRA-----LAFGCGARVCLGEPLARLELFVVLTRLLQA 448
Query: 419 F 419
F
Sbjct: 449 F 449
>AM086564-1|CAJ31103.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/181 (32%), Positives = 91/181 (50%), Gaps = 25/181 (13%)
Query: 255 EEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE-------------VMSK 301
E + ++ A D+L+ G +T AN+++ + +PE Q++L+EE V K
Sbjct: 278 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYK 337
Query: 302 ESKRY--LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEH 358
+ R L A I E +R+ PVV L RTT+ +I GY +P+G + Q E
Sbjct: 338 DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETV 397
Query: 359 YPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILEN 418
+ RP EF P+R+L +P +A FG G R C+G +A LE+ LT++L+
Sbjct: 398 WERPHEFWPDRFL----EPGKNSRA-----LAFGCGARVCLGEPLARLELFVVLTRLLQA 448
Query: 419 F 419
F
Sbjct: 449 F 449
>AL929593-2|CAI41778.1| 465|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 465
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/181 (32%), Positives = 91/181 (50%), Gaps = 25/181 (13%)
Query: 255 EEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE-------------VMSK 301
E + ++ A D+L+ G +T AN+++ + +PE Q++L+EE V K
Sbjct: 249 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYK 308
Query: 302 ESKRY--LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEH 358
+ R L A I E +R+ PVV L RTT+ +I GY +P+G + Q E
Sbjct: 309 DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETV 368
Query: 359 YPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILEN 418
+ RP EF P+R+L +P +A FG G R C+G +A LE+ LT++L+
Sbjct: 369 WERPHEFWPDRFL----EPGKNSRA-----LAFGCGARVCLGEPLARLELFVVLTRLLQA 419
Query: 419 F 419
F
Sbjct: 420 F 420
>AL929593-1|CAI41779.1| 495|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 495
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/181 (32%), Positives = 91/181 (50%), Gaps = 25/181 (13%)
Query: 255 EEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE-------------VMSK 301
E + ++ A D+L+ G +T AN+++ + +PE Q++L+EE V K
Sbjct: 279 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYK 338
Query: 302 ESKRY--LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEH 358
+ R L A I E +R+ PVV L RTT+ +I GY +P+G + Q E
Sbjct: 339 DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETV 398
Query: 359 YPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILEN 418
+ RP EF P+R+L +P +A FG G R C+G +A LE+ LT++L+
Sbjct: 399 WERPHEFWPDRFL----EPGKNSRA-----LAFGCGARVCLGEPLARLELFVVLTRLLQA 449
Query: 419 F 419
F
Sbjct: 450 F 450
>AL662849-19|CAI17480.1| 465|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 465
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/181 (32%), Positives = 91/181 (50%), Gaps = 25/181 (13%)
Query: 255 EEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE-------------VMSK 301
E + ++ A D+L+ G +T AN+++ + +PE Q++L+EE V K
Sbjct: 249 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYK 308
Query: 302 ESKRY--LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEH 358
+ R L A I E +R+ PVV L RTT+ +I GY +P+G + Q E
Sbjct: 309 DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETV 368
Query: 359 YPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILEN 418
+ RP EF P+R+L +P +A FG G R C+G +A LE+ LT++L+
Sbjct: 369 WERPHEFWPDRFL----EPGKNSRA-----LAFGCGARVCLGEPLARLELFVVLTRLLQA 419
Query: 419 F 419
F
Sbjct: 420 F 420
>AL662849-18|CAI17479.1| 495|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 495
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/181 (32%), Positives = 91/181 (50%), Gaps = 25/181 (13%)
Query: 255 EEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE-------------VMSK 301
E + ++ A D+L+ G +T AN+++ + +PE Q++L+EE V K
Sbjct: 279 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYK 338
Query: 302 ESKRY--LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEH 358
+ R L A I E +R+ PVV L RTT+ +I GY +P+G + Q E
Sbjct: 339 DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETV 398
Query: 359 YPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILEN 418
+ RP EF P+R+L +P +A FG G R C+G +A LE+ LT++L+
Sbjct: 399 WERPHEFWPDRFL----EPGKNSRA-----LAFGCGARVCLGEPLARLELFVVLTRLLQA 449
Query: 419 F 419
F
Sbjct: 450 F 450
>AL645922-24|CAI41754.1| 495|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 495
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/181 (32%), Positives = 91/181 (50%), Gaps = 25/181 (13%)
Query: 255 EEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE-------------VMSK 301
E + ++ A D+L+ G +T AN+++ + +PE Q++L+EE V K
Sbjct: 279 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYK 338
Query: 302 ESKRY--LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEH 358
+ R L A I E +R+ PVV L RTT+ +I GY +P+G + Q E
Sbjct: 339 DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETV 398
Query: 359 YPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILEN 418
+ RP EF P+R+L +P +A FG G R C+G +A LE+ LT++L+
Sbjct: 399 WERPHEFWPDRFL----EPGKNSRA-----LAFGCGARVCLGEPLARLELFVVLTRLLQA 449
Query: 419 F 419
F
Sbjct: 450 F 450
>AL645922-23|CAI41755.1| 465|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 465
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/181 (32%), Positives = 91/181 (50%), Gaps = 25/181 (13%)
Query: 255 EEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE-------------VMSK 301
E + ++ A D+L+ G +T AN+++ + +PE Q++L+EE V K
Sbjct: 249 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYK 308
Query: 302 ESKRY--LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEH 358
+ R L A I E +R+ PVV L RTT+ +I GY +P+G + Q E
Sbjct: 309 DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETV 368
Query: 359 YPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILEN 418
+ RP EF P+R+L +P +A FG G R C+G +A LE+ LT++L+
Sbjct: 369 WERPHEFWPDRFL----EPGKNSRA-----LAFGCGARVCLGEPLARLELFVVLTRLLQA 419
Query: 419 F 419
F
Sbjct: 420 F 420
>AL049547-7|CAB89301.1| 495|Homo sapiens dJ34F7.3 (cytochrome P450,
subfamily XXIA (steroid 21-hydroxylase, congenital a
protein.
Length = 495
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/181 (32%), Positives = 91/181 (50%), Gaps = 25/181 (13%)
Query: 255 EEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE-------------VMSK 301
E + ++ A D+L+ G +T AN+++ + +PE Q++L+EE V K
Sbjct: 279 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYK 338
Query: 302 ESKRY--LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEH 358
+ R L A I E +R+ PVV L RTT+ +I GY +P+G + Q E
Sbjct: 339 DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETV 398
Query: 359 YPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILEN 418
+ RP EF P+R+L +P +A FG G R C+G +A LE+ LT++L+
Sbjct: 399 WERPHEFWPDRFL----EPGKNSRA-----LAFGCGARVCLGEPLARLELFVVLTRLLQA 449
Query: 419 F 419
F
Sbjct: 450 F 450
>AK054616-1|BAB70774.1| 465|Homo sapiens protein ( Homo sapiens
cDNA FLJ30054 fis, clone ADRGL1000160, highly similar to
CYTOCHROME P450 XXIB (EC 1.14.99.10). ).
Length = 465
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/183 (31%), Positives = 91/183 (49%), Gaps = 25/183 (13%)
Query: 253 INEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE-------------VM 299
+ E + ++ A D+L+ G +T AN+++ +PE Q++L+EE V
Sbjct: 247 LQEGHVHMAAVDLLIGGTETTANTLSWAAVFLLHHPEIQQRLQEELDHELGPGASSSRVP 306
Query: 300 SKESKRY--LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSME 356
K+ R L A I E +R+ PVV L RTT+ +I GY +P+G + Q E
Sbjct: 307 YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDE 366
Query: 357 EHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKIL 416
+ RP EF P+R+L +P +A FG G R C+G +A LE+ LT++L
Sbjct: 367 TVWERPHEFWPDRFL----EPGKNSRA-----LAFGCGARVCLGEPLARLELFVVLTRLL 417
Query: 417 ENF 419
+ F
Sbjct: 418 QAF 420
>AF077974-1|AAD45405.1| 403|Homo sapiens cytochrome P450
21-hydroxylase protein.
Length = 403
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/181 (32%), Positives = 91/181 (50%), Gaps = 25/181 (13%)
Query: 255 EEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE-------------VMSK 301
E + ++ A D+L+ G +T AN+++ + +PE Q++L+EE V K
Sbjct: 187 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYK 246
Query: 302 ESKRY--LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEH 358
+ R L A I E +R+ PVV L RTT+ +I GY +P+G + Q E
Sbjct: 247 DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETV 306
Query: 359 YPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILEN 418
+ RP EF P+R+L +P +A FG G R C+G +A LE+ LT++L+
Sbjct: 307 WERPHEFWPDRFL----EPGKNSRA-----LAFGCGARVCLGEPLARLELFVVLTRLLQA 357
Query: 419 F 419
F
Sbjct: 358 F 358
>AF019413-2|AAB67982.1| 495|Homo sapiens cytochrome P450
21-hydroxylase protein.
Length = 495
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/181 (32%), Positives = 91/181 (50%), Gaps = 25/181 (13%)
Query: 255 EEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE-------------VMSK 301
E + ++ A D+L+ G +T AN+++ + +PE Q++L+EE V K
Sbjct: 279 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYK 338
Query: 302 ESKRY--LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEH 358
+ R L A I E +R+ PVV L RTT+ +I GY +P+G + Q E
Sbjct: 339 DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETV 398
Query: 359 YPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILEN 418
+ RP EF P+R+L +P +A FG G R C+G +A LE+ LT++L+
Sbjct: 399 WERPHEFWPDRFL----EPGKNSRA-----LAFGCGARVCLGEPLARLELFVVLTRLLQA 449
Query: 419 F 419
F
Sbjct: 450 F 450
>M21550-1|AAA52063.1| 495|Homo sapiens CYP21 protein.
Length = 495
Score = 74.9 bits (176), Expect = 5e-13
Identities = 58/181 (32%), Positives = 91/181 (50%), Gaps = 25/181 (13%)
Query: 255 EEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE-------------VMSK 301
E + ++ A D+L+ G +T AN+++ + +PE Q++L+EE V K
Sbjct: 279 EGHLHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYK 338
Query: 302 ESKRY--LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEH 358
+ R L A I E +R+ PVV L RTT+ +I GY +P+G + Q E
Sbjct: 339 DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETV 398
Query: 359 YPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILEN 418
+ RP EF P+R+L +P +A FG G R C+G +A LE+ LT++L+
Sbjct: 399 WERPHEFWPDRFL----EPGKNSRA-----LAFGCGARVCLGEPLARLELFVVLTRLLQA 449
Query: 419 F 419
F
Sbjct: 450 F 450
>BC100981-1|AAI00982.1| 393|Homo sapiens CYP3A43 protein protein.
Length = 393
Score = 74.9 bits (176), Expect = 5e-13
Identities = 49/167 (29%), Positives = 82/167 (49%), Gaps = 17/167 (10%)
Query: 265 MLVAGVDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIK 312
++ A DT + ++ +Y A +P+ Q+KL+EE+ + + YL +
Sbjct: 192 IIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVN 251
Query: 313 ETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
ET+R+ PVVS R K+ I G +PKG+ V L +++ P +F PER+
Sbjct: 252 ETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSK 311
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
D + + ++ PFG G R+CIG R A I+ + + L+NF
Sbjct: 312 KNKDSI---DLYRYI--PFGAGPRNCIGMRFALTNIKLAVIRALQNF 353
>AY390425-1|AAQ92353.1| 503|Homo sapiens cytochrome P450 CYP3A43.1
protein.
Length = 503
Score = 74.9 bits (176), Expect = 5e-13
Identities = 49/167 (29%), Positives = 82/167 (49%), Gaps = 17/167 (10%)
Query: 265 MLVAGVDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIK 312
++ A DT + ++ +Y A +P+ Q+KL+EE+ + + YL +
Sbjct: 302 IIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVN 361
Query: 313 ETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
ET+R+ PVVS R K+ I G +PKG+ V L +++ P +F PER+
Sbjct: 362 ETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSK 421
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
D + + ++ PFG G R+CIG R A I+ + + L+NF
Sbjct: 422 KNKDSI---DLYRYI--PFGAGPRNCIGMRFALTNIKLAVIRALQNF 463
>AF337813-1|AAK38841.1| 503|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 503
Score = 74.9 bits (176), Expect = 5e-13
Identities = 49/167 (29%), Positives = 82/167 (49%), Gaps = 17/167 (10%)
Query: 265 MLVAGVDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIK 312
++ A DT + ++ +Y A +P+ Q+KL+EE+ + + YL +
Sbjct: 302 IIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVN 361
Query: 313 ETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
ET+R+ PVVS R K+ I G +PKG+ V L +++ P +F PER+
Sbjct: 362 ETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSK 421
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
D + + ++ PFG G R+CIG R A I+ + + L+NF
Sbjct: 422 KNKDSI---DLYRYI--PFGAGPRNCIGMRFALTNIKLAVIRALQNF 463
>AF319634-1|AAK00325.1| 503|Homo sapiens cytochrome P450 CYP3A43
protein.
Length = 503
Score = 74.9 bits (176), Expect = 5e-13
Identities = 49/167 (29%), Positives = 82/167 (49%), Gaps = 17/167 (10%)
Query: 265 MLVAGVDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIK 312
++ A DT + ++ +Y A +P+ Q+KL+EE+ + + YL +
Sbjct: 302 IIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVN 361
Query: 313 ETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
ET+R+ PVVS R K+ I G +PKG+ V L +++ P +F PER+
Sbjct: 362 ETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSK 421
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
D + + ++ PFG G R+CIG R A I+ + + L+NF
Sbjct: 422 KNKDSI---DLYRYI--PFGAGPRNCIGMRFALTNIKLAVIRALQNF 463
>AF280108-1|AAG33009.1| 503|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 503
Score = 74.9 bits (176), Expect = 5e-13
Identities = 49/167 (29%), Positives = 82/167 (49%), Gaps = 17/167 (10%)
Query: 265 MLVAGVDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIK 312
++ A DT + ++ +Y A +P+ Q+KL+EE+ + + YL +
Sbjct: 302 IIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVN 361
Query: 313 ETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
ET+R+ PVVS R K+ I G +PKG+ V L +++ P +F PER+
Sbjct: 362 ETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSK 421
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
D + + ++ PFG G R+CIG R A I+ + + L+NF
Sbjct: 422 KNKDSI---DLYRYI--PFGAGPRNCIGMRFALTNIKLAVIRALQNF 463
>AC011904-4|AAS07395.1| 503|Homo sapiens unknown protein.
Length = 503
Score = 74.9 bits (176), Expect = 5e-13
Identities = 49/167 (29%), Positives = 82/167 (49%), Gaps = 17/167 (10%)
Query: 265 MLVAGVDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIK 312
++ A DT + ++ +Y A +P+ Q+KL+EE+ + + YL +
Sbjct: 302 IIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVN 361
Query: 313 ETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
ET+R+ PVVS R K+ I G +PKG+ V L +++ P +F PER+
Sbjct: 362 ETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSK 421
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
D + + ++ PFG G R+CIG R A I+ + + L+NF
Sbjct: 422 KNKDSI---DLYRYI--PFGAGPRNCIGMRFALTNIKLAVIRALQNF 463
>M33317-1|AAA52138.1| 494|Homo sapiens CYP2A protein.
Length = 494
Score = 74.5 bits (175), Expect = 7e-13
Identities = 56/204 (27%), Positives = 100/204 (49%), Gaps = 21/204 (10%)
Query: 260 IMAT-DMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-----MSKESK-------RY 306
+M+T ++ +AG +TV+ ++ L K+PE + K+ EE+ +++ K Y
Sbjct: 292 MMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPY 351
Query: 307 LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEF 365
++A I E R V+ +L RR K+ + +PKG +V + + P +F
Sbjct: 352 MEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDF 411
Query: 366 IPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYG 425
P+ +L DK + K+ FV PF G R C G +A +E+ F T +++NFR++
Sbjct: 412 NPQHFLDDKGQ---FKKSDAFV--PFSIGKRYCFGEGLARMELFLFFTTVMQNFRLKSSQ 466
Query: 426 PPPKIIQTS--INYFTGPFNFVFN 447
P I +S + + T P N+ +
Sbjct: 467 SPKDIDVSSKHVGFATIPRNYTMS 490
>AY356349-1|AAQ55485.1| 522|Homo sapiens cytochrome P450 protein.
Length = 522
Score = 74.5 bits (175), Expect = 7e-13
Identities = 41/130 (31%), Positives = 66/130 (50%), Gaps = 3/130 (2%)
Query: 305 RYLKACIKETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTE 364
RY+ +KE +R++P VSG R + + + GY +PKG V ++ +D Y P E
Sbjct: 367 RYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSVMYSIRDTHETAAVYRSPPE 426
Query: 365 -FIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEW 423
F PER+ A + D G + PFG G RSC+G+ +A+ ++ +++ R E
Sbjct: 427 GFDPERFGAAREDS--RGASSRLHYIPFGGGARSCLGQELAQAVLQLLAVELVRTARWEL 484
Query: 424 YGPPPKIIQT 433
P +QT
Sbjct: 485 ATPAFPAMQT 494
>BC117165-1|AAI17166.1| 494|Homo sapiens cytochrome P450, family 2,
subfamily A, polypeptide 7 protein.
Length = 494
Score = 74.1 bits (174), Expect = 9e-13
Identities = 57/205 (27%), Positives = 100/205 (48%), Gaps = 23/205 (11%)
Query: 260 IMAT-DMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-----MSKESK-------RY 306
+M+T ++ +AG +TV+ ++ L K+PE + K+ EE+ +++ K Y
Sbjct: 292 MMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPY 351
Query: 307 LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEF 365
++A I E R V+ +L RR K+ + +PKG +V + + P +F
Sbjct: 352 MEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDF 411
Query: 366 IPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYG 425
P+ +L DK + K+ FV PF G R C G +A +E+ F T +++NFR++
Sbjct: 412 NPQHFLDDKGQ---FKKSDAFV--PFSIGKRYCFGEGLARMELFLFFTTVMQNFRLK-SS 465
Query: 426 PPPKIIQTS---INYFTGPFNFVFN 447
PK I S + + T P N+ +
Sbjct: 466 QSPKDIDVSPKHVGFATIPRNYTMS 490
>X02612-1|CAA26458.1| 512|Homo sapiens cytochrome P(1)-450 protein.
Length = 512
Score = 73.7 bits (173), Expect = 1e-12
Identities = 62/227 (27%), Positives = 112/227 (49%), Gaps = 19/227 (8%)
Query: 214 MFQLQEDLSKYFINKAMRNINKNENKPDEQKGVLEKL-LDINEEYAYIMATDMLVAGVDT 272
M ++ ++ K F +R+I + + ++K + E + +++E + D+ AG DT
Sbjct: 262 MQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDT 321
Query: 273 VANSIAATLYLFAKNPEKQEKLREEV--MSKESKR----------YLKACIKETMRMMPV 320
V +I+ +L NP Q K++EE+ + S+R Y++A I ET R +
Sbjct: 322 VTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSL 381
Query: 321 VSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLY 379
V + TT++ ++ G+++PKG V ++ ++ + P+EF+PER+L
Sbjct: 382 VPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDG---A 438
Query: 380 YGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGP 426
K + FG G R CIG +A E+ FL +L+ RVE+ P
Sbjct: 439 IDKVLSEKVIIFGMGKRKCIGETVARWEVFLFLAILLQ--RVEFSVP 483
>X04300-1|CAA27843.1| 512|Homo sapiens P-450 c protein.
Length = 512
Score = 73.3 bits (172), Expect = 2e-12
Identities = 63/227 (27%), Positives = 111/227 (48%), Gaps = 19/227 (8%)
Query: 214 MFQLQEDLSKYFINKAMRNINKNENKPDEQKGVLEKL-LDINEEYAYIMATDMLVAGVDT 272
M ++ ++ K F +R+I + + ++K + E + +++E + D+ AG DT
Sbjct: 262 MQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDT 321
Query: 273 VANSIAATLYLFAKNPEKQEKLREEV--MSKESKR----------YLKACIKETMRMMPV 320
V +I+ +L NP Q K++EE+ + S+R Y++A I ET R
Sbjct: 322 VTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSF 381
Query: 321 VSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLY 379
V + TT++ ++ G+++PKG V ++ ++ + P+EF+PER+L
Sbjct: 382 VPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDG---A 438
Query: 380 YGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGP 426
K + FG G R CIG IA E+ FL +L+ RVE+ P
Sbjct: 439 IDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQ--RVEFSVP 483
>EF094025-1|ABK41999.1| 512|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 1 protein.
Length = 512
Score = 73.3 bits (172), Expect = 2e-12
Identities = 63/227 (27%), Positives = 111/227 (48%), Gaps = 19/227 (8%)
Query: 214 MFQLQEDLSKYFINKAMRNINKNENKPDEQKGVLEKL-LDINEEYAYIMATDMLVAGVDT 272
M ++ ++ K F +R+I + + ++K + E + +++E + D+ AG DT
Sbjct: 262 MQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDT 321
Query: 273 VANSIAATLYLFAKNPEKQEKLREEV--MSKESKR----------YLKACIKETMRMMPV 320
V +I+ +L NP Q K++EE+ + S+R Y++A I ET R
Sbjct: 322 VTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSF 381
Query: 321 VSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLY 379
V + TT++ ++ G+++PKG V ++ ++ + P+EF+PER+L
Sbjct: 382 VPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDG---A 438
Query: 380 YGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGP 426
K + FG G R CIG IA E+ FL +L+ RVE+ P
Sbjct: 439 IDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQ--RVEFSVP 483
>BC023019-1|AAH23019.1| 512|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 1 protein.
Length = 512
Score = 73.3 bits (172), Expect = 2e-12
Identities = 63/227 (27%), Positives = 111/227 (48%), Gaps = 19/227 (8%)
Query: 214 MFQLQEDLSKYFINKAMRNINKNENKPDEQKGVLEKL-LDINEEYAYIMATDMLVAGVDT 272
M ++ ++ K F +R+I + + ++K + E + +++E + D+ AG DT
Sbjct: 262 MQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDT 321
Query: 273 VANSIAATLYLFAKNPEKQEKLREEV--MSKESKR----------YLKACIKETMRMMPV 320
V +I+ +L NP Q K++EE+ + S+R Y++A I ET R
Sbjct: 322 VTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSF 381
Query: 321 VSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLY 379
V + TT++ ++ G+++PKG V ++ ++ + P+EF+PER+L
Sbjct: 382 VPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDG---A 438
Query: 380 YGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGP 426
K + FG G R CIG IA E+ FL +L+ RVE+ P
Sbjct: 439 IDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQ--RVEFSVP 483
>AY310359-1|AAQ76692.1| 484|Homo sapiens cytochrome P450 1A1
variant protein.
Length = 484
Score = 73.3 bits (172), Expect = 2e-12
Identities = 63/227 (27%), Positives = 111/227 (48%), Gaps = 19/227 (8%)
Query: 214 MFQLQEDLSKYFINKAMRNINKNENKPDEQKGVLEKL-LDINEEYAYIMATDMLVAGVDT 272
M ++ ++ K F +R+I + + ++K + E + +++E + D+ AG DT
Sbjct: 234 MQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDT 293
Query: 273 VANSIAATLYLFAKNPEKQEKLREEV--MSKESKR----------YLKACIKETMRMMPV 320
V +I+ +L NP Q K++EE+ + S+R Y++A I ET R
Sbjct: 294 VTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSF 353
Query: 321 VSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLY 379
V + TT++ ++ G+++PKG V ++ ++ + P+EF+PER+L
Sbjct: 354 VPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDG---A 410
Query: 380 YGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGP 426
K + FG G R CIG IA E+ FL +L+ RVE+ P
Sbjct: 411 IDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQ--RVEFSVP 455
>AM236047-1|CAJ84704.1| 251|Homo sapiens cytochrome P450 1A1
protein.
Length = 251
Score = 73.3 bits (172), Expect = 2e-12
Identities = 63/227 (27%), Positives = 111/227 (48%), Gaps = 19/227 (8%)
Query: 214 MFQLQEDLSKYFINKAMRNINKNENKPDEQKGVLEKL-LDINEEYAYIMATDMLVAGVDT 272
M ++ ++ K F +R+I + + ++K + E + +++E + D+ AG DT
Sbjct: 1 MQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDT 60
Query: 273 VANSIAATLYLFAKNPEKQEKLREEV--MSKESKR----------YLKACIKETMRMMPV 320
V +I+ +L NP Q K++EE+ + S+R Y++A I ET R
Sbjct: 61 VTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSF 120
Query: 321 VSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLY 379
V + TT++ ++ G+++PKG V ++ ++ + P+EF+PER+L
Sbjct: 121 VPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDG---A 177
Query: 380 YGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGP 426
K + FG G R CIG IA E+ FL +L+ RVE+ P
Sbjct: 178 IDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQ--RVEFSVP 222
>AM183948-1|CAJ75802.1| 494|Homo sapiens steroid 21-hydroxylase
protein.
Length = 494
Score = 73.3 bits (172), Expect = 2e-12
Identities = 57/181 (31%), Positives = 90/181 (49%), Gaps = 25/181 (13%)
Query: 255 EEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE-------------VMSK 301
E + ++ A D+L+ G + AN+++ + +PE Q++L+EE V K
Sbjct: 278 EGHVHMAAVDLLIGGTENTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYK 337
Query: 302 ESKRY--LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEH 358
+ R L A I E +R+ PVV L RTT+ +I GY +P+G + Q E
Sbjct: 338 DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETV 397
Query: 359 YPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILEN 418
+ RP EF P+R+L +P +A FG G R C+G +A LE+ LT++L+
Sbjct: 398 WERPHEFWPDRFL----EPGKNSRA-----LAFGCGARVCLGEPLARLELFVVLTRLLQA 448
Query: 419 F 419
F
Sbjct: 449 F 449
>AK223113-1|BAD96833.1| 512|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 1 variant protein.
Length = 512
Score = 73.3 bits (172), Expect = 2e-12
Identities = 63/227 (27%), Positives = 111/227 (48%), Gaps = 19/227 (8%)
Query: 214 MFQLQEDLSKYFINKAMRNINKNENKPDEQKGVLEKL-LDINEEYAYIMATDMLVAGVDT 272
M ++ ++ K F +R+I + + ++K + E + +++E + D+ AG DT
Sbjct: 262 MQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDT 321
Query: 273 VANSIAATLYLFAKNPEKQEKLREEV--MSKESKR----------YLKACIKETMRMMPV 320
V +I+ +L NP Q K++EE+ + S+R Y++A I ET R
Sbjct: 322 VTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSF 381
Query: 321 VSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLY 379
V + TT++ ++ G+++PKG V ++ ++ + P+EF+PER+L
Sbjct: 382 VPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDG---A 438
Query: 380 YGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGP 426
K + FG G R CIG IA E+ FL +L+ RVE+ P
Sbjct: 439 IDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQ--RVEFSVP 483
>AF280109-1|AAG33010.1| 504|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 504
Score = 73.3 bits (172), Expect = 2e-12
Identities = 49/167 (29%), Positives = 79/167 (47%), Gaps = 16/167 (9%)
Query: 265 MLVAGVDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIK 312
++ A DT + ++ +Y A +P+ Q+KL+EE+ + + YL +
Sbjct: 302 IIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVN 361
Query: 313 ETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
ET+R+ PVVS R K+ I G +PKG+ V L +++ P +F PE +
Sbjct: 362 ETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFS 421
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
KN + PFG G R+CIG R A I+ + + L+NF
Sbjct: 422 KKNK----DSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNF 464
>AF253322-1|AAK25727.1| 512|Homo sapiens cytochrome P450 protein.
Length = 512
Score = 73.3 bits (172), Expect = 2e-12
Identities = 63/227 (27%), Positives = 111/227 (48%), Gaps = 19/227 (8%)
Query: 214 MFQLQEDLSKYFINKAMRNINKNENKPDEQKGVLEKL-LDINEEYAYIMATDMLVAGVDT 272
M ++ ++ K F +R+I + + ++K + E + +++E + D+ AG DT
Sbjct: 262 MQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDT 321
Query: 273 VANSIAATLYLFAKNPEKQEKLREEV--MSKESKR----------YLKACIKETMRMMPV 320
V +I+ +L NP Q K++EE+ + S+R Y++A I ET R
Sbjct: 322 VTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSF 381
Query: 321 VSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLY 379
V + TT++ ++ G+++PKG V ++ ++ + P+EF+PER+L
Sbjct: 382 VPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDG---A 438
Query: 380 YGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGP 426
K + FG G R CIG IA E+ FL +L+ RVE+ P
Sbjct: 439 IDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQ--RVEFSVP 483
>AC011904-5|AAS07394.1| 504|Homo sapiens unknown protein.
Length = 504
Score = 73.3 bits (172), Expect = 2e-12
Identities = 49/167 (29%), Positives = 79/167 (47%), Gaps = 16/167 (9%)
Query: 265 MLVAGVDTVANSIAATLYLFAKNPEKQEKLREEVMSKESKR------------YLKACIK 312
++ A DT + ++ +Y A +P+ Q+KL+EE+ + + YL +
Sbjct: 302 IIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVN 361
Query: 313 ETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
ET+R+ PVVS R K+ I G +PKG+ V L +++ P +F PE +
Sbjct: 362 ETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFS 421
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
KN + PFG G R+CIG R A I+ + + L+NF
Sbjct: 422 KKNK----DSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNF 464
>K03191-1|AAA52139.1| 512|Homo sapiens CYP1A1 protein.
Length = 512
Score = 72.9 bits (171), Expect = 2e-12
Identities = 62/227 (27%), Positives = 111/227 (48%), Gaps = 19/227 (8%)
Query: 214 MFQLQEDLSKYFINKAMRNINKNENKPDEQKGVLEKL-LDINEEYAYIMATDMLVAGVDT 272
M ++ ++ K F +R+I + + ++K + E + +++E + D+ AG DT
Sbjct: 262 MQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDT 321
Query: 273 VANSIAATLYLFAKNPEKQEKLREEV--MSKESKR----------YLKACIKETMRMMPV 320
V +I+ +L NP Q K++EE+ + S+R Y++A I ET R
Sbjct: 322 VTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSF 381
Query: 321 VSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLY 379
V + TT++ ++ G+++PKG V ++ ++ + P+EF+PER+L
Sbjct: 382 VPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDG---A 438
Query: 380 YGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGP 426
K + FG G R CIG +A E+ FL +L+ RVE+ P
Sbjct: 439 IDKVLSEKVIIFGMGKRKCIGETVARWEVFLFLAILLQ--RVEFSVP 483
>Z00036-1|CAA77335.1| 515|Homo sapiens protein ( Human mRNA for
cytochrome P-3-450. ).
Length = 515
Score = 72.5 bits (170), Expect = 3e-12
Identities = 83/295 (28%), Positives = 136/295 (46%), Gaps = 29/295 (9%)
Query: 157 VAFGIRLNCFDPNLAENSPEK-KLIECVHQIFNLS---NQLDFQPSLWHIFSTPTYK-KA 211
VA I CF + E+S E L++ H+ + N LDF P L ++ + + KA
Sbjct: 196 VANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKA 255
Query: 212 MK---MFQLQEDLSKY---FINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIMATDM 265
++ LQ+ + ++ F ++R+I K +KG I +E + D+
Sbjct: 256 FNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFK-HSKKGPRASGNLIPQEKIVNLVNDI 314
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREE---VMSKESK---------RYLKACIKE 313
AG DTV +I+ +L PE Q K+++E V+ +E + YL+A I E
Sbjct: 315 FGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILE 374
Query: 314 TMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
T R + + TT++ + G+++PK V ++ E + P+EF PER+L
Sbjct: 375 TFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPP 427
D K M FG G R CIG +A+ EI FL +L+ ++E+ PP
Sbjct: 435 --ADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ--QLEFSVPP 485
>X13930-1|CAA32118.1| 494|Homo sapiens protein ( Human CYP2A4 mRNA
for P-450 IIA4 protein. ).
Length = 494
Score = 72.5 bits (170), Expect = 3e-12
Identities = 55/205 (26%), Positives = 99/205 (48%), Gaps = 23/205 (11%)
Query: 260 IMAT-DMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-----MSKESK-------RY 306
+M T ++ + G +TV+ ++ L K+PE + K+ EE+ +++ K Y
Sbjct: 292 VMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPY 351
Query: 307 LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEF 365
++A I E R V+ +L RR K+ + +PKG +V + + P +F
Sbjct: 352 MEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDF 411
Query: 366 IPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYG 425
P+ +L +K + K+ FV PF G R+C G +A +E+ F T +++NFR++
Sbjct: 412 NPQHFLNEKGQ---FKKSDAFV--PFSIGKRNCFGEGLARMELFLFFTTVMQNFRLK-SS 465
Query: 426 PPPKIIQTS---INYFTGPFNFVFN 447
PK I S + + T P N+ +
Sbjct: 466 QSPKDIDVSPKHVGFATIPRNYTMS 490
>X13929-1|CAA32117.1| 448|Homo sapiens P-450 IIA3 protein (1 is 3rd
base in codon) protein.
Length = 448
Score = 72.5 bits (170), Expect = 3e-12
Identities = 55/205 (26%), Positives = 99/205 (48%), Gaps = 23/205 (11%)
Query: 260 IMAT-DMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-----MSKESK-------RY 306
+M T ++ + G +TV+ ++ L K+PE + K+ EE+ +++ K Y
Sbjct: 246 VMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPY 305
Query: 307 LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEF 365
++A I E R V+ +L RR K+ + +PKG +V + + P +F
Sbjct: 306 MEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDF 365
Query: 366 IPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYG 425
P+ +L +K + K+ FV PF G R+C G +A +E+ F T +++NFR++
Sbjct: 366 NPQHFLNEKGQ---FKKSDAFV--PFSIGKRNCFGEGLARMELFLFFTTVMQNFRLK-SS 419
Query: 426 PPPKIIQTS---INYFTGPFNFVFN 447
PK I S + + T P N+ +
Sbjct: 420 QSPKDIDVSPKHVGFATIPRNYTMS 444
>M55053-1|AAA52146.1| 515|Homo sapiens cytochrome P3-450 protein.
Length = 515
Score = 72.5 bits (170), Expect = 3e-12
Identities = 83/295 (28%), Positives = 136/295 (46%), Gaps = 29/295 (9%)
Query: 157 VAFGIRLNCFDPNLAENSPEK-KLIECVHQIFNLS---NQLDFQPSLWHIFSTPTYK-KA 211
VA I CF + E+S E L++ H+ + N LDF P L ++ + + KA
Sbjct: 196 VANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKA 255
Query: 212 MK---MFQLQEDLSKY---FINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIMATDM 265
++ LQ+ + ++ F ++R+I K +KG I +E + D+
Sbjct: 256 FNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFK-HSKKGPRASGNLIPQEKIVNLVNDI 314
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREE---VMSKESK---------RYLKACIKE 313
AG DTV +I+ +L PE Q K+++E V+ +E + YL+A I E
Sbjct: 315 FGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILE 374
Query: 314 TMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
T R + + TT++ + G+++PK V ++ E + P+EF PER+L
Sbjct: 375 TFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPP 427
D K M FG G R CIG +A+ EI FL +L+ ++E+ PP
Sbjct: 435 --ADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ--QLEFSVPP 485
>M33318-1|AAA52067.1| 494|Homo sapiens CYP2A protein.
Length = 494
Score = 72.5 bits (170), Expect = 3e-12
Identities = 55/205 (26%), Positives = 99/205 (48%), Gaps = 23/205 (11%)
Query: 260 IMAT-DMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-----MSKESK-------RY 306
+M T ++ + G +TV+ ++ L K+PE + K+ EE+ +++ K Y
Sbjct: 292 VMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPY 351
Query: 307 LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEF 365
++A I E R V+ +L RR K+ + +PKG +V + + P +F
Sbjct: 352 MEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDF 411
Query: 366 IPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYG 425
P+ +L +K + K+ FV PF G R+C G +A +E+ F T +++NFR++
Sbjct: 412 NPQHFLNEKGQ---FKKSDAFV--PFSIGKRNCFGEGLARMELFLFFTTVMQNFRLK-SS 465
Query: 426 PPPKIIQTS---INYFTGPFNFVFN 447
PK I S + + T P N+ +
Sbjct: 466 QSPKDIDVSPKHVGFATIPRNYTMS 490
>M31667-1|AAA52163.1| 515|Homo sapiens CYP1A2 protein.
Length = 515
Score = 72.5 bits (170), Expect = 3e-12
Identities = 83/295 (28%), Positives = 136/295 (46%), Gaps = 29/295 (9%)
Query: 157 VAFGIRLNCFDPNLAENSPEK-KLIECVHQIFNLS---NQLDFQPSLWHIFSTPTYK-KA 211
VA I CF + E+S E L++ H+ + N LDF P L ++ + + KA
Sbjct: 196 VANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKA 255
Query: 212 MK---MFQLQEDLSKY---FINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIMATDM 265
++ LQ+ + ++ F ++R+I K +KG I +E + D+
Sbjct: 256 FNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFK-HSKKGPRASGNLIPQEKIVNLVNDI 314
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREE---VMSKESK---------RYLKACIKE 313
AG DTV +I+ +L PE Q K+++E V+ +E + YL+A I E
Sbjct: 315 FGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILE 374
Query: 314 TMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
T R + + TT++ + G+++PK V ++ E + P+EF PER+L
Sbjct: 375 TFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPP 427
D K M FG G R CIG +A+ EI FL +L+ ++E+ PP
Sbjct: 435 --ADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ--QLEFSVPP 485
>M12079-1|AAA52152.1| 191|Homo sapiens POR protein.
Length = 191
Score = 72.5 bits (170), Expect = 3e-12
Identities = 55/189 (29%), Positives = 93/189 (49%), Gaps = 18/189 (9%)
Query: 251 LDINEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV--MSKESKR--- 305
+ +++E + D+ AG DTV +I+ +L NP Q K++EE+ + S+R
Sbjct: 6 VQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRL 65
Query: 306 -------YLKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEE 357
Y++A I ET R V + TT++ ++ G+++PKG V ++ ++
Sbjct: 66 SDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQK 125
Query: 358 HYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILE 417
+ P+EF+PER+L K + FG G R CIG +A E+ FL +L+
Sbjct: 126 LWVNPSEFLPERFLTPDG---AIDKVLSEKVIIFGMGKRKCIGETVARWEVFLFLAILLQ 182
Query: 418 NFRVEWYGP 426
RVE+ P
Sbjct: 183 --RVEFSVP 189
>L00389-1|AAA35738.1| 516|Homo sapiens protein ( Human cytochrome
P-450 4 gene, exon 7, and three Alu repeats in the 3'
flank. ).
Length = 516
Score = 72.5 bits (170), Expect = 3e-12
Identities = 83/295 (28%), Positives = 136/295 (46%), Gaps = 29/295 (9%)
Query: 157 VAFGIRLNCFDPNLAENSPEK-KLIECVHQIFNLS---NQLDFQPSLWHIFSTPTYK-KA 211
VA I CF + E+S E L++ H+ + N LDF P L ++ + + KA
Sbjct: 196 VANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKA 255
Query: 212 MK---MFQLQEDLSKY---FINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIMATDM 265
++ LQ+ + ++ F ++R+I K +KG I +E + D+
Sbjct: 256 FNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFK-HSKKGPRASGNLIPQEKIVNLVNDI 314
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREE---VMSKESK---------RYLKACIKE 313
AG DTV +I+ +L PE Q K+++E V+ +E + YL+A I E
Sbjct: 315 FGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILE 374
Query: 314 TMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
T R + + TT++ + G+++PK V ++ E + P+EF PER+L
Sbjct: 375 TFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPP 427
D K M FG G R CIG +A+ EI FL +L+ ++E+ PP
Sbjct: 435 --ADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ--QLEFSVPP 485
>DQ022432-1|AAY26399.1| 516|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 2 protein.
Length = 516
Score = 72.5 bits (170), Expect = 3e-12
Identities = 83/295 (28%), Positives = 136/295 (46%), Gaps = 29/295 (9%)
Query: 157 VAFGIRLNCFDPNLAENSPEK-KLIECVHQIFNLS---NQLDFQPSLWHIFSTPTYK-KA 211
VA I CF + E+S E L++ H+ + N LDF P L ++ + + KA
Sbjct: 196 VANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKA 255
Query: 212 MK---MFQLQEDLSKY---FINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIMATDM 265
++ LQ+ + ++ F ++R+I K +KG I +E + D+
Sbjct: 256 FNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFK-HSKKGPRASGNLIPQEKIVNLVNDI 314
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREE---VMSKESK---------RYLKACIKE 313
AG DTV +I+ +L PE Q K+++E V+ +E + YL+A I E
Sbjct: 315 FGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILE 374
Query: 314 TMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
T R + + TT++ + G+++PK V ++ E + P+EF PER+L
Sbjct: 375 TFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPP 427
D K M FG G R CIG +A+ EI FL +L+ ++E+ PP
Sbjct: 435 --ADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ--QLEFSVPP 485
>BC096256-1|AAH96256.1| 494|Homo sapiens cytochrome P450, family 2,
subfamily A, polypeptide 6 protein.
Length = 494
Score = 72.5 bits (170), Expect = 3e-12
Identities = 55/205 (26%), Positives = 99/205 (48%), Gaps = 23/205 (11%)
Query: 260 IMAT-DMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-----MSKESK-------RY 306
+M T ++ + G +TV+ ++ L K+PE + K+ EE+ +++ K Y
Sbjct: 292 VMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPY 351
Query: 307 LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEF 365
++A I E R V+ +L RR K+ + +PKG +V + + P +F
Sbjct: 352 MEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDF 411
Query: 366 IPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYG 425
P+ +L +K + K+ FV PF G R+C G +A +E+ F T +++NFR++
Sbjct: 412 NPQHFLNEKGQ---FKKSDAFV--PFSIGKRNCFGEGLARMELFLFFTTVMQNFRLK-SS 465
Query: 426 PPPKIIQTS---INYFTGPFNFVFN 447
PK I S + + T P N+ +
Sbjct: 466 QSPKDIDVSPRHVGFATIPRNYTMS 490
>BC096255-1|AAH96255.1| 494|Homo sapiens cytochrome P450, family 2,
subfamily A, polypeptide 6 protein.
Length = 494
Score = 72.5 bits (170), Expect = 3e-12
Identities = 55/205 (26%), Positives = 99/205 (48%), Gaps = 23/205 (11%)
Query: 260 IMAT-DMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-----MSKESK-------RY 306
+M T ++ + G +TV+ ++ L K+PE + K+ EE+ +++ K Y
Sbjct: 292 VMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPY 351
Query: 307 LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEF 365
++A I E R V+ +L RR K+ + +PKG +V + + P +F
Sbjct: 352 MEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDF 411
Query: 366 IPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYG 425
P+ +L +K + K+ FV PF G R+C G +A +E+ F T +++NFR++
Sbjct: 412 NPQHFLNEKGQ---FKKSDAFV--PFSIGKRNCFGEGLARMELFLFFTTVMQNFRLK-SS 465
Query: 426 PPPKIIQTS---INYFTGPFNFVFN 447
PK I S + + T P N+ +
Sbjct: 466 QSPKDIDVSPKHVGFATIPRNYTMS 490
>BC096254-1|AAH96254.1| 494|Homo sapiens cytochrome P450, family 2,
subfamily A, polypeptide 6 protein.
Length = 494
Score = 72.5 bits (170), Expect = 3e-12
Identities = 55/205 (26%), Positives = 99/205 (48%), Gaps = 23/205 (11%)
Query: 260 IMAT-DMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-----MSKESK-------RY 306
+M T ++ + G +TV+ ++ L K+PE + K+ EE+ +++ K Y
Sbjct: 292 VMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPY 351
Query: 307 LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEF 365
++A I E R V+ +L RR K+ + +PKG +V + + P +F
Sbjct: 352 MEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDF 411
Query: 366 IPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYG 425
P+ +L +K + K+ FV PF G R+C G +A +E+ F T +++NFR++
Sbjct: 412 NPQHFLNEKGQ---FKKSDAFV--PFSIGKRNCFGEGLARMELFLFFTTVMQNFRLK-SS 465
Query: 426 PPPKIIQTS---INYFTGPFNFVFN 447
PK I S + + T P N+ +
Sbjct: 466 QSPKDIDVSPKHVGFATIPRNYTMS 490
>BC096253-1|AAH96253.3| 494|Homo sapiens cytochrome P450, family 2,
subfamily A, polypeptide 6 protein.
Length = 494
Score = 72.5 bits (170), Expect = 3e-12
Identities = 55/205 (26%), Positives = 99/205 (48%), Gaps = 23/205 (11%)
Query: 260 IMAT-DMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-----MSKESK-------RY 306
+M T ++ + G +TV+ ++ L K+PE + K+ EE+ +++ K Y
Sbjct: 292 VMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPY 351
Query: 307 LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEF 365
++A I E R V+ +L RR K+ + +PKG +V + + P +F
Sbjct: 352 MEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDF 411
Query: 366 IPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYG 425
P+ +L +K + K+ FV PF G R+C G +A +E+ F T +++NFR++
Sbjct: 412 NPQHFLNEKGQ---FKKSDAFV--PFSIGKRNCFGEGLARMELFLFFTTVMQNFRLK-SS 465
Query: 426 PPPKIIQTS---INYFTGPFNFVFN 447
PK I S + + T P N+ +
Sbjct: 466 QSPKDIDVSPKHVGFATIPRNYTMS 490
>BC067428-1|AAH67428.1| 516|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 2 protein.
Length = 516
Score = 72.5 bits (170), Expect = 3e-12
Identities = 83/295 (28%), Positives = 136/295 (46%), Gaps = 29/295 (9%)
Query: 157 VAFGIRLNCFDPNLAENSPEK-KLIECVHQIFNLS---NQLDFQPSLWHIFSTPTYK-KA 211
VA I CF + E+S E L++ H+ + N LDF P L ++ + + KA
Sbjct: 196 VANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKA 255
Query: 212 MK---MFQLQEDLSKY---FINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIMATDM 265
++ LQ+ + ++ F ++R+I K +KG I +E + D+
Sbjct: 256 FNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFK-HSKKGPRASGNLIPQEKIVNLVNDI 314
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREE---VMSKESK---------RYLKACIKE 313
AG DTV +I+ +L PE Q K+++E V+ +E + YL+A I E
Sbjct: 315 FGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILE 374
Query: 314 TMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
T R + + TT++ + G+++PK V ++ E + P+EF PER+L
Sbjct: 375 TFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPP 427
D K M FG G R CIG +A+ EI FL +L+ ++E+ PP
Sbjct: 435 --ADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ--QLEFSVPP 485
>BC067427-1|AAH67427.1| 516|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 2 protein.
Length = 516
Score = 72.5 bits (170), Expect = 3e-12
Identities = 83/295 (28%), Positives = 136/295 (46%), Gaps = 29/295 (9%)
Query: 157 VAFGIRLNCFDPNLAENSPEK-KLIECVHQIFNLS---NQLDFQPSLWHIFSTPTYK-KA 211
VA I CF + E+S E L++ H+ + N LDF P L ++ + + KA
Sbjct: 196 VANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKA 255
Query: 212 MK---MFQLQEDLSKY---FINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIMATDM 265
++ LQ+ + ++ F ++R+I K +KG I +E + D+
Sbjct: 256 FNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFK-HSKKGPRASGNLIPQEKIVNLVNDI 314
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREE---VMSKESK---------RYLKACIKE 313
AG DTV +I+ +L PE Q K+++E V+ +E + YL+A I E
Sbjct: 315 FGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILE 374
Query: 314 TMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
T R + + TT++ + G+++PK V ++ E + P+EF PER+L
Sbjct: 375 TFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPP 427
D K M FG G R CIG +A+ EI FL +L+ ++E+ PP
Sbjct: 435 --ADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ--QLEFSVPP 485
>BC067426-1|AAH67426.1| 516|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 2 protein.
Length = 516
Score = 72.5 bits (170), Expect = 3e-12
Identities = 83/295 (28%), Positives = 136/295 (46%), Gaps = 29/295 (9%)
Query: 157 VAFGIRLNCFDPNLAENSPEK-KLIECVHQIFNLS---NQLDFQPSLWHIFSTPTYK-KA 211
VA I CF + E+S E L++ H+ + N LDF P L ++ + + KA
Sbjct: 196 VANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKA 255
Query: 212 MK---MFQLQEDLSKY---FINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIMATDM 265
++ LQ+ + ++ F ++R+I K +KG I +E + D+
Sbjct: 256 FNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFK-HSKKGPRASGNLIPQEKIVNLVNDI 314
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREE---VMSKESK---------RYLKACIKE 313
AG DTV +I+ +L PE Q K+++E V+ +E + YL+A I E
Sbjct: 315 FGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILE 374
Query: 314 TMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
T R + + TT++ + G+++PK V ++ E + P+EF PER+L
Sbjct: 375 TFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPP 427
D K M FG G R CIG +A+ EI FL +L+ ++E+ PP
Sbjct: 435 --ADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ--QLEFSVPP 485
>BC067425-1|AAH67425.1| 516|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 2 protein.
Length = 516
Score = 72.5 bits (170), Expect = 3e-12
Identities = 83/295 (28%), Positives = 136/295 (46%), Gaps = 29/295 (9%)
Query: 157 VAFGIRLNCFDPNLAENSPEK-KLIECVHQIFNLS---NQLDFQPSLWHIFSTPTYK-KA 211
VA I CF + E+S E L++ H+ + N LDF P L ++ + + KA
Sbjct: 196 VANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKA 255
Query: 212 MK---MFQLQEDLSKY---FINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIMATDM 265
++ LQ+ + ++ F ++R+I K +KG I +E + D+
Sbjct: 256 FNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFK-HSKKGPRASGNLIPQEKIVNLVNDI 314
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREE---VMSKESK---------RYLKACIKE 313
AG DTV +I+ +L PE Q K+++E V+ +E + YL+A I E
Sbjct: 315 FGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILE 374
Query: 314 TMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
T R + + TT++ + G+++PK V ++ E + P+EF PER+L
Sbjct: 375 TFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPP 427
D K M FG G R CIG +A+ EI FL +L+ ++E+ PP
Sbjct: 435 --ADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ--QLEFSVPP 485
>BC067424-1|AAH67424.1| 516|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 2 protein.
Length = 516
Score = 72.5 bits (170), Expect = 3e-12
Identities = 83/295 (28%), Positives = 136/295 (46%), Gaps = 29/295 (9%)
Query: 157 VAFGIRLNCFDPNLAENSPEK-KLIECVHQIFNLS---NQLDFQPSLWHIFSTPTYK-KA 211
VA I CF + E+S E L++ H+ + N LDF P L ++ + + KA
Sbjct: 196 VANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKA 255
Query: 212 MK---MFQLQEDLSKY---FINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIMATDM 265
++ LQ+ + ++ F ++R+I K +KG I +E + D+
Sbjct: 256 FNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFK-HSKKGPRASGNLIPQEKIVNLVNDI 314
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREE---VMSKESK---------RYLKACIKE 313
AG DTV +I+ +L PE Q K+++E V+ +E + YL+A I E
Sbjct: 315 FGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILE 374
Query: 314 TMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
T R + + TT++ + G+++PK V ++ E + P+EF PER+L
Sbjct: 375 TFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPP 427
D K M FG G R CIG +A+ EI FL +L+ ++E+ PP
Sbjct: 435 --ADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ--QLEFSVPP 485
>AM183950-1|CAJ75804.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 72.5 bits (170), Expect = 3e-12
Identities = 57/181 (31%), Positives = 90/181 (49%), Gaps = 25/181 (13%)
Query: 255 EEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE-------------VMSK 301
E + ++ A D+L+ G +T AN+++ + +PE Q++L+EE V K
Sbjct: 278 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYK 337
Query: 302 ESKRY--LKACIKETMRMMPVVSGNLRR-TTKEYNILGYHVPKGIDVAFAHQDLSSMEEH 358
+ R L A I E +R+ PVV L TT+ +I GY +P+G + Q E
Sbjct: 338 DRARLPLLNATIAEVLRLRPVVPLALPHCTTRPSSISGYDIPEGTVIIPNLQGAHLDETV 397
Query: 359 YPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILEN 418
+ RP EF P+R+L +P +A FG G R C+G +A LE+ LT++L+
Sbjct: 398 WERPHEFWPDRFL----EPGKNSRA-----LAFGCGARVCLGEPLARLELFVVLTRLLQA 448
Query: 419 F 419
F
Sbjct: 449 F 449
>AF253322-2|AAK25728.1| 516|Homo sapiens cytochrome P450 protein.
Length = 516
Score = 72.5 bits (170), Expect = 3e-12
Identities = 83/295 (28%), Positives = 136/295 (46%), Gaps = 29/295 (9%)
Query: 157 VAFGIRLNCFDPNLAENSPEK-KLIECVHQIFNLS---NQLDFQPSLWHIFSTPTYK-KA 211
VA I CF + E+S E L++ H+ + N LDF P L ++ + + KA
Sbjct: 196 VANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKA 255
Query: 212 MK---MFQLQEDLSKY---FINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIMATDM 265
++ LQ+ + ++ F ++R+I K +KG I +E + D+
Sbjct: 256 FNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFK-HSKKGPRASGNLIPQEKIVNLVNDI 314
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREE---VMSKESK---------RYLKACIKE 313
AG DTV +I+ +L PE Q K+++E V+ +E + YL+A I E
Sbjct: 315 FGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILE 374
Query: 314 TMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
T R + + TT++ + G+++PK V ++ E + P+EF PER+L
Sbjct: 375 TFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPP 427
D K M FG G R CIG +A+ EI FL +L+ ++E+ PP
Sbjct: 435 --ADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ--QLEFSVPP 485
>AF182274-1|AAF13599.1| 516|Homo sapiens cytochrome P450-1A2
protein.
Length = 516
Score = 72.5 bits (170), Expect = 3e-12
Identities = 83/295 (28%), Positives = 136/295 (46%), Gaps = 29/295 (9%)
Query: 157 VAFGIRLNCFDPNLAENSPEK-KLIECVHQIFNLS---NQLDFQPSLWHIFSTPTYK-KA 211
VA I CF + E+S E L++ H+ + N LDF P L ++ + + KA
Sbjct: 196 VANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKA 255
Query: 212 MK---MFQLQEDLSKY---FINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIMATDM 265
++ LQ+ + ++ F ++R+I K +KG I +E + D+
Sbjct: 256 FNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFK-HSKKGPRASGNLIPQEKIVNLVNDV 314
Query: 266 LVAGVDTVANSIAATLYLFAKNPEKQEKLREE---VMSKESK---------RYLKACIKE 313
AG DTV +I+ +L PE Q K+++E V+ +E + YL+A I E
Sbjct: 315 FGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILE 374
Query: 314 TMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLA 372
T R + + TT++ + G+++PK V ++ E + P+EF PER+L
Sbjct: 375 TFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434
Query: 373 DKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPP 427
D K M FG G R CIG +A+ EI FL +L+ ++E+ PP
Sbjct: 435 --ADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ--QLEFSVPP 485
>U22027-1|AAB40518.1| 494|Homo sapiens cytochrome P450 protein.
Length = 494
Score = 71.3 bits (167), Expect = 6e-12
Identities = 56/205 (27%), Positives = 100/205 (48%), Gaps = 23/205 (11%)
Query: 260 IMAT-DMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-----MSKESK-------RY 306
+M+T ++ +AG +TV+ ++ L K+PE + K+ EE+ +++ K Y
Sbjct: 292 MMSTLNLFIAGTETVSTTLHYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPY 351
Query: 307 LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEF 365
++A I E R V+ +L RR K+ + +PKGI+V + + P +F
Sbjct: 352 MEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGIEVFPMLGSVLRDLRFFSNPRDF 411
Query: 366 IPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYG 425
P+ +L +K + K FV PF R+C G +A +E+ F T +++NFR++
Sbjct: 412 NPQHFLGEKGQ---FKKRDAFV--PFSIRKRNCFGEGLARMELFLFFTTVMQNFRLK-SS 465
Query: 426 PPPKIIQTS---INYFTGPFNFVFN 447
PK I S + + T P N+ +
Sbjct: 466 QSPKDIDVSPKHVGFATIPRNYTMS 490
>M12792-1|AAB59440.1| 494|Homo sapiens steroid 21-hydroxylase
protein.
Length = 494
Score = 71.3 bits (167), Expect = 6e-12
Identities = 56/181 (30%), Positives = 90/181 (49%), Gaps = 25/181 (13%)
Query: 255 EEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE-------------VMSK 301
E + ++ A D+L+ G +T AN+++ + +PE Q++L+EE V K
Sbjct: 278 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYK 337
Query: 302 ESKRY--LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEH 358
+ R L A I E +R+ PVV L RTT+ +I GY +P+G + Q E
Sbjct: 338 DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETV 397
Query: 359 YPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILEN 418
+ RP EF P+R+L +P +A FG G C+G +A L++ LT++L+
Sbjct: 398 WERPHEFWPDRFL----EPGKNSRA-----LAFGCGAPVCLGEPLARLDLFVVLTRLLQA 448
Query: 419 F 419
F
Sbjct: 449 F 449
>AF182275-1|AAF13600.1| 494|Homo sapiens cytochrome P450-2A6
protein.
Length = 494
Score = 71.3 bits (167), Expect = 6e-12
Identities = 55/205 (26%), Positives = 99/205 (48%), Gaps = 23/205 (11%)
Query: 260 IMAT-DMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-----MSKESK-------RY 306
+M T ++ + G +TV+ ++ L K+PE + K+ EE+ +++ K Y
Sbjct: 292 VMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPY 351
Query: 307 LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEF 365
++A I E R V+ +L RR K+ + +PKG +V + + P +F
Sbjct: 352 MEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDF 411
Query: 366 IPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYG 425
P+ +L +K + K+ FV PF G R+C G +A +E+ F T +++NFR++
Sbjct: 412 NPQHFLNEKGQ---FKKSDAFV--PFSIGKRNCFGEGLARMELFLFFTTVMQNFRLK-SS 465
Query: 426 PPPKIIQTS---INYFTGPFNFVFN 447
PK I S + + T P N+ +
Sbjct: 466 QSPKDIDVSPKHVVFATIPRNYTMS 490
>X13897-1|CAA32097.1| 489|Homo sapiens protein ( Human mRNA for
cytochrome P-450IIA. ).
Length = 489
Score = 70.9 bits (166), Expect = 8e-12
Identities = 54/205 (26%), Positives = 99/205 (48%), Gaps = 23/205 (11%)
Query: 260 IMAT-DMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-----MSKESK-------RY 306
+M T ++ + G +TV+ ++ L K+PE + ++ EE+ +++ K Y
Sbjct: 287 VMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAQVHEEIDRVIGKNRQPKFEDRAKMPY 346
Query: 307 LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEF 365
++A I E R V+ +L RR K+ + +PKG +V + + P +F
Sbjct: 347 MEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDF 406
Query: 366 IPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYG 425
P+ +L +K + K+ FV PF G R+C G +A +E+ F T +++NFR++
Sbjct: 407 NPQHFLNEKGQ---FKKSDAFV--PFSIGKRNCFGEGLARMELFLFFTTVMQNFRLK-SS 460
Query: 426 PPPKIIQTS---INYFTGPFNFVFN 447
PK I S + + T P N+ +
Sbjct: 461 QSPKDIDVSPKHVGFATIPRNYTMS 485
>AK223108-1|BAD96828.1| 512|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 1 variant protein.
Length = 512
Score = 70.9 bits (166), Expect = 8e-12
Identities = 62/227 (27%), Positives = 109/227 (48%), Gaps = 19/227 (8%)
Query: 214 MFQLQEDLSKYFINKAMRNINKNENKPDEQKGVLEKL-LDINEEYAYIMATDMLVAGVDT 272
M ++ ++ K F +R+I + + ++K + E + +++E + D+ AG DT
Sbjct: 262 MQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDT 321
Query: 273 VANSIAATLYLFAKNPEKQEKLREEV--MSKESKR----------YLKACIKETMRMMPV 320
V + + +L NP Q K++EE+ + S+R Y++A I ET R
Sbjct: 322 VTTATSWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSF 381
Query: 321 VSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLY 379
V + TT++ ++ G+++PKG V + ++ + P+EF+PER+L
Sbjct: 382 VPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQIDHDQKLWVNPSEFLPERFLTPDG---A 438
Query: 380 YGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGP 426
K + FG G R CIG IA E+ FL +L+ RVE+ P
Sbjct: 439 IDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQ--RVEFSVP 483
>L16876-1|AAA02630.1| 490|Homo sapiens cytochrome P-4502C18
protein.
Length = 490
Score = 70.5 bits (165), Expect = 1e-11
Identities = 66/262 (25%), Positives = 115/262 (43%), Gaps = 21/262 (8%)
Query: 188 NLSNQLDFQPSLWH-IFSTPTYKKAMKMFQLQEDLSKYFINKAMRNINKNENKPDEQKGV 246
N +D+ P + I Y K+ + +++E +N A I+ K +++K
Sbjct: 218 NFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHN 277
Query: 247 LEKLLDINEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-------- 298
+ + A + TDM AG +T + ++ L L K PE K++EE+
Sbjct: 278 QQSEFTVESLIATV--TDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNR 335
Query: 299 ----MSKESKRYLKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLS 353
+ Y A + E R + ++ NL T + Y +PKG+ + + +
Sbjct: 336 SPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGMTIITSLTSVL 395
Query: 354 SMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLT 413
++ +P P F P +L DK+ + K+ F+ PF G R C+G +A +E+ FLT
Sbjct: 396 HNDKEFPNPEMFDPGHFL-DKSGN--FKKSDYFM--PFSAGKRMCMGEGLARMELFLFLT 450
Query: 414 KILENFRVEWYGPPPKIIQTSI 435
IL+NF ++ P I T I
Sbjct: 451 TILQNFNLKSQVDPKDIDITPI 472
>BC109084-1|AAI09085.1| 448|Homo sapiens CYP24A1 protein protein.
Length = 448
Score = 70.5 bits (165), Expect = 1e-11
Identities = 70/246 (28%), Positives = 116/246 (47%), Gaps = 30/246 (12%)
Query: 117 IDEVAQEMMNRMKSKLDENNRLQAKFDDEMNLWALESIGVVAFGIRLNCFDPNLAENSPE 176
I+EV + M R+ DE ++ + E+N W+ ESI +V + R N + +
Sbjct: 179 INEVLADFMGRIDELCDERGHVEDLYS-ELNKWSFESICLVLYEKRFGLLQKNAGDEAVN 237
Query: 177 KKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSKYFINKAMRNINKN 236
I + + + ++ P H S T K++Q L+ I K+++ N
Sbjct: 238 --FIMAIKTMMSTFGRMMVTPVELHK-SLNT-----KVWQ-DHTLAWDTIFKSVKACIDN 288
Query: 237 ENKPDEQKGVLEKLLDI------NEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEK 290
+ Q+ + L DI +++ Y T++ +A V+T ANS+ LY ++NP+
Sbjct: 289 RLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQV 348
Query: 291 QEKLREEVMS---------KESKR---YLKACIKETMRMMPVVSGNLRRTTKEYNILG-Y 337
Q+KL +E+ S E R YLKAC+KE+MR+ P V RT + +LG Y
Sbjct: 349 QQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFT-TRTLDKATVLGEY 407
Query: 338 HVPKGI 343
+PKGI
Sbjct: 408 ALPKGI 413
>BC109083-1|AAI09084.1| 448|Homo sapiens CYP24A1 protein protein.
Length = 448
Score = 70.5 bits (165), Expect = 1e-11
Identities = 70/246 (28%), Positives = 116/246 (47%), Gaps = 30/246 (12%)
Query: 117 IDEVAQEMMNRMKSKLDENNRLQAKFDDEMNLWALESIGVVAFGIRLNCFDPNLAENSPE 176
I+EV + M R+ DE ++ + E+N W+ ESI +V + R N + +
Sbjct: 179 INEVLADFMGRIDELCDERGHVEDLYS-ELNKWSFESICLVLYEKRFGLLQKNAGDEAVN 237
Query: 177 KKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSKYFINKAMRNINKN 236
I + + + ++ P H S T K++Q L+ I K+++ N
Sbjct: 238 --FIMAIKTMMSTFGRMMVTPVELHK-SLNT-----KVWQ-DHTLAWDTIFKSVKACIDN 288
Query: 237 ENKPDEQKGVLEKLLDI------NEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEK 290
+ Q+ + L DI +++ Y T++ +A V+T ANS+ LY ++NP+
Sbjct: 289 RLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQV 348
Query: 291 QEKLREEVMS---------KESKR---YLKACIKETMRMMPVVSGNLRRTTKEYNILG-Y 337
Q+KL +E+ S E R YLKAC+KE+MR+ P V RT + +LG Y
Sbjct: 349 QQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFT-TRTLDKATVLGEY 407
Query: 338 HVPKGI 343
+PKGI
Sbjct: 408 ALPKGI 413
>AL138805-2|CAM27343.1| 448|Homo sapiens cytochrome P450, family
24, subfamily A, polypeptide 1 protein.
Length = 448
Score = 70.5 bits (165), Expect = 1e-11
Identities = 70/246 (28%), Positives = 116/246 (47%), Gaps = 30/246 (12%)
Query: 117 IDEVAQEMMNRMKSKLDENNRLQAKFDDEMNLWALESIGVVAFGIRLNCFDPNLAENSPE 176
I+EV + M R+ DE ++ + E+N W+ ESI +V + R N + +
Sbjct: 179 INEVLADFMGRIDELCDERGHVEDLYS-ELNKWSFESICLVLYEKRFGLLQKNAGDEAVN 237
Query: 177 KKLIECVHQIFNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEDLSKYFINKAMRNINKN 236
I + + + ++ P H S T K++Q L+ I K+++ N
Sbjct: 238 --FIMAIKTMMSTFGRMMVTPVELHK-SLNT-----KVWQ-DHTLAWDTIFKSVKACIDN 288
Query: 237 ENKPDEQKGVLEKLLDI------NEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEK 290
+ Q+ + L DI +++ Y T++ +A V+T ANS+ LY ++NP+
Sbjct: 289 RLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQV 348
Query: 291 QEKLREEVMS---------KESKR---YLKACIKETMRMMPVVSGNLRRTTKEYNILG-Y 337
Q+KL +E+ S E R YLKAC+KE+MR+ P V RT + +LG Y
Sbjct: 349 QQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFT-TRTLDKATVLGEY 407
Query: 338 HVPKGI 343
+PKGI
Sbjct: 408 ALPKGI 413
>X65962-1|CAA46778.1| 356|Homo sapiens cytochrome P-450 II C
protein.
Length = 356
Score = 70.1 bits (164), Expect = 1e-11
Identities = 55/214 (25%), Positives = 95/214 (44%), Gaps = 24/214 (11%)
Query: 235 KNENKPDEQKGVLEKLLDINEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKL 294
K E + D QK + E I A D+L AG +T + ++ L L K+PE K+
Sbjct: 136 KMEQEKDNQKS------EFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKV 189
Query: 295 REEV------------MSKESKRYLKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPK 341
+EE+ + Y A + E R + ++ +L T + Y +PK
Sbjct: 190 QEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDIKFRNYLIPK 249
Query: 342 GIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGR 401
G + + + + +P P F P +L + + + K++ F+ PF G R C+G
Sbjct: 250 GTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGN---FKKSNYFM--PFSAGKRICVGE 304
Query: 402 RIAELEIETFLTKILENFRVEWYGPPPKIIQTSI 435
+A +E+ FLT IL+NF ++ P + T +
Sbjct: 305 GLARMELFLFLTFILQNFNLKSLIDPKDLDTTPV 338
>U37143-1|AAC50370.2| 502|Homo sapiens cytochrome P450
monooxygenase CYP2J2 protein.
Length = 502
Score = 70.1 bits (164), Expect = 1e-11
Identities = 49/179 (27%), Positives = 81/179 (45%), Gaps = 19/179 (10%)
Query: 254 NEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSK 301
+EE D+ AG +T + ++ L A PE QEK++ E+ ++
Sbjct: 297 HEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAAR 356
Query: 302 ESKRYLKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYP 360
ES Y A I E RM ++ N+ R T + + GYH+PKG + L +
Sbjct: 357 ESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWA 416
Query: 361 RPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
P F P+ +L + + K F+ PF G R+C+G ++A E+ F T +++ F
Sbjct: 417 TPDTFNPDHFLENGQ----FKKREAFM--PFSIGKRACLGEQLARTELFIFFTSLMQKF 469
>M17252-1|AAA59985.1| 230|Homo sapiens CYP21 protein.
Length = 230
Score = 70.1 bits (164), Expect = 1e-11
Identities = 57/181 (31%), Positives = 90/181 (49%), Gaps = 25/181 (13%)
Query: 255 EEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE-------------VMSK 301
E + ++ A D+L+ G +T AN+++ + + E Q++L+EE V K
Sbjct: 14 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHLEIQQRLQEELDHELGPGASSSRVPYK 73
Query: 302 ESKRY--LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEH 358
+ R L A I E +R+ PVV L RTT+ +I GY +P+G + Q E
Sbjct: 74 DRARLPLLIATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETV 133
Query: 359 YPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILEN 418
+ RP EF P+R+L +P +A FG G R C+G +A LE+ LT++L+
Sbjct: 134 WERPHEFWPDRFL----EPGKNSRA-----LAFGCGARVCLGEPLARLELFVVLTRLLQA 184
Query: 419 F 419
F
Sbjct: 185 F 185
>BC067433-1|AAH67433.1| 493|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 1 protein.
Length = 493
Score = 70.1 bits (164), Expect = 1e-11
Identities = 47/176 (26%), Positives = 80/176 (45%), Gaps = 18/176 (10%)
Query: 260 IMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE------------VMSKESKRYL 307
+ D+ AG +T + ++ L + K PE +EKL EE + ++ Y+
Sbjct: 291 VTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYM 350
Query: 308 KACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFI 366
A ++E R + +V NL T++ GY +PKG V + + +P P +F
Sbjct: 351 DAVVREIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFK 410
Query: 367 PERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
PE +L ++N Y PF G R C G +A +E+ L IL++F ++
Sbjct: 411 PEHFL-NENGKFKYSD----YFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLK 461
>BC032594-1|AAH32594.1| 502|Homo sapiens cytochrome P450, family 2,
subfamily J, polypeptide 2 protein.
Length = 502
Score = 70.1 bits (164), Expect = 1e-11
Identities = 49/179 (27%), Positives = 81/179 (45%), Gaps = 19/179 (10%)
Query: 254 NEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSK 301
+EE D+ AG +T + ++ L A PE QEK++ E+ ++
Sbjct: 297 HEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAAR 356
Query: 302 ESKRYLKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYP 360
ES Y A I E RM ++ N+ R T + + GYH+PKG + L +
Sbjct: 357 ESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWA 416
Query: 361 RPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
P F P+ +L + + K F+ PF G R+C+G ++A E+ F T +++ F
Sbjct: 417 TPDTFNPDHFLENGQ----FKKREAFM--PFSIGKRACLGEQLARTELFIFFTSLMQKF 469
>AY426985-1|AAQ93356.1| 502|Homo sapiens cytochrome P450, family 2,
subfamily J, polypeptide 2 protein.
Length = 502
Score = 70.1 bits (164), Expect = 1e-11
Identities = 49/179 (27%), Positives = 81/179 (45%), Gaps = 19/179 (10%)
Query: 254 NEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSK 301
+EE D+ AG +T + ++ L A PE QEK++ E+ ++
Sbjct: 297 HEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAAR 356
Query: 302 ESKRYLKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYP 360
ES Y A I E RM ++ N+ R T + + GYH+PKG + L +
Sbjct: 357 ESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWA 416
Query: 361 RPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
P F P+ +L + + K F+ PF G R+C+G ++A E+ F T +++ F
Sbjct: 417 TPDTFNPDHFLENGQ----FKKREAFM--PFSIGKRACLGEQLARTELFIFFTSLMQKF 469
>AF272142-1|AAM44456.1| 502|Homo sapiens cytochrome P450 protein.
Length = 502
Score = 70.1 bits (164), Expect = 1e-11
Identities = 49/179 (27%), Positives = 81/179 (45%), Gaps = 19/179 (10%)
Query: 254 NEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSK 301
+EE D+ AG +T + ++ L A PE QEK++ E+ ++
Sbjct: 297 HEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAAR 356
Query: 302 ESKRYLKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYP 360
ES Y A I E RM ++ N+ R T + + GYH+PKG + L +
Sbjct: 357 ESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWA 416
Query: 361 RPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
P F P+ +L + + K F+ PF G R+C+G ++A E+ F T +++ F
Sbjct: 417 TPDTFNPDHFLENGQ----FKKREAFM--PFSIGKRACLGEQLARTELFIFFTSLMQKF 469
>M61856-1|AAB59356.1| 490|Homo sapiens cytochrome protein.
Length = 490
Score = 69.7 bits (163), Expect = 2e-11
Identities = 66/262 (25%), Positives = 114/262 (43%), Gaps = 21/262 (8%)
Query: 188 NLSNQLDFQPSLWH-IFSTPTYKKAMKMFQLQEDLSKYFINKAMRNINKNENKPDEQKGV 246
N +D+ P + I Y K+ + +++E +N A I+ K +++K
Sbjct: 218 NFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHN 277
Query: 247 LEKLLDINEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-------- 298
+ + A + TDM AG +T + ++ L L K PE K++EE+
Sbjct: 278 QQSEFTVESLIATV--TDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNR 335
Query: 299 ----MSKESKRYLKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLS 353
+ Y A + E R + ++ NL T + Y +PKG + + +
Sbjct: 336 SPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVL 395
Query: 354 SMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLT 413
++ +P P F P +L DK+ + K+ F+ PF G R C+G +A +E+ FLT
Sbjct: 396 HNDKEFPNPEMFDPGHFL-DKSGN--FKKSDYFM--PFSAGKRMCMGEGLARMELFLFLT 450
Query: 414 KILENFRVEWYGPPPKIIQTSI 435
IL+NF ++ P I T I
Sbjct: 451 TILQNFNLKSQVDPKDIDITPI 472
>BC096258-1|AAH96258.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 18 protein.
Length = 490
Score = 69.7 bits (163), Expect = 2e-11
Identities = 66/262 (25%), Positives = 114/262 (43%), Gaps = 21/262 (8%)
Query: 188 NLSNQLDFQPSLWH-IFSTPTYKKAMKMFQLQEDLSKYFINKAMRNINKNENKPDEQKGV 246
N +D+ P + I Y K+ + +++E +N A I+ K +++K
Sbjct: 218 NFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHN 277
Query: 247 LEKLLDINEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-------- 298
+ + A + TDM AG +T + ++ L L K PE K++EE+
Sbjct: 278 QQSEFTVESLIATV--TDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNR 335
Query: 299 ----MSKESKRYLKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLS 353
+ Y A + E R + ++ NL T + Y +PKG + + +
Sbjct: 336 SPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVL 395
Query: 354 SMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLT 413
++ +P P F P +L DK+ + K+ F+ PF G R C+G +A +E+ FLT
Sbjct: 396 HNDKEFPNPEMFDPGHFL-DKSGN--FKKSDYFM--PFSAGKRMCMGEGLARMELFLFLT 450
Query: 414 KILENFRVEWYGPPPKIIQTSI 435
IL+NF ++ P I T I
Sbjct: 451 TILQNFNLKSQVDPKDIDITPI 472
>BC096257-1|AAH96257.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 18 protein.
Length = 490
Score = 69.7 bits (163), Expect = 2e-11
Identities = 66/262 (25%), Positives = 114/262 (43%), Gaps = 21/262 (8%)
Query: 188 NLSNQLDFQPSLWH-IFSTPTYKKAMKMFQLQEDLSKYFINKAMRNINKNENKPDEQKGV 246
N +D+ P + I Y K+ + +++E +N A I+ K +++K
Sbjct: 218 NFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHN 277
Query: 247 LEKLLDINEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-------- 298
+ + A + TDM AG +T + ++ L L K PE K++EE+
Sbjct: 278 QQSEFTVESLIATV--TDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNR 335
Query: 299 ----MSKESKRYLKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLS 353
+ Y A + E R + ++ NL T + Y +PKG + + +
Sbjct: 336 SPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVL 395
Query: 354 SMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLT 413
++ +P P F P +L DK+ + K+ F+ PF G R C+G +A +E+ FLT
Sbjct: 396 HNDKEFPNPEMFDPGHFL-DKSGN--FKKSDYFM--PFSAGKRMCMGEGLARMELFLFLT 450
Query: 414 KILENFRVEWYGPPPKIIQTSI 435
IL+NF ++ P I T I
Sbjct: 451 TILQNFNLKSQVDPKDIDITPI 472
>BC069666-1|AAH69666.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 18 protein.
Length = 490
Score = 69.7 bits (163), Expect = 2e-11
Identities = 66/262 (25%), Positives = 114/262 (43%), Gaps = 21/262 (8%)
Query: 188 NLSNQLDFQPSLWH-IFSTPTYKKAMKMFQLQEDLSKYFINKAMRNINKNENKPDEQKGV 246
N +D+ P + I Y K+ + +++E +N A I+ K +++K
Sbjct: 218 NFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHN 277
Query: 247 LEKLLDINEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-------- 298
+ + A + TDM AG +T + ++ L L K PE K++EE+
Sbjct: 278 QQSEFTVESLIATV--TDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNR 335
Query: 299 ----MSKESKRYLKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLS 353
+ Y A + E R + ++ NL T + Y +PKG + + +
Sbjct: 336 SPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVL 395
Query: 354 SMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLT 413
++ +P P F P +L DK+ + K+ F+ PF G R C+G +A +E+ FLT
Sbjct: 396 HNDKEFPNPEMFDPGHFL-DKSGN--FKKSDYFM--PFSAGKRMCMGEGLARMELFLFLT 450
Query: 414 KILENFRVEWYGPPPKIIQTSI 435
IL+NF ++ P I T I
Sbjct: 451 TILQNFNLKSQVDPKDIDITPI 472
>AL583836-1|CAH74067.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 18 protein.
Length = 490
Score = 69.7 bits (163), Expect = 2e-11
Identities = 66/262 (25%), Positives = 114/262 (43%), Gaps = 21/262 (8%)
Query: 188 NLSNQLDFQPSLWH-IFSTPTYKKAMKMFQLQEDLSKYFINKAMRNINKNENKPDEQKGV 246
N +D+ P + I Y K+ + +++E +N A I+ K +++K
Sbjct: 218 NFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHN 277
Query: 247 LEKLLDINEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-------- 298
+ + A + TDM AG +T + ++ L L K PE K++EE+
Sbjct: 278 QQSEFTVESLIATV--TDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNR 335
Query: 299 ----MSKESKRYLKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLS 353
+ Y A + E R + ++ NL T + Y +PKG + + +
Sbjct: 336 SPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVL 395
Query: 354 SMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLT 413
++ +P P F P +L DK+ + K+ F+ PF G R C+G +A +E+ FLT
Sbjct: 396 HNDKEFPNPEMFDPGHFL-DKSGN--FKKSDYFM--PFSAGKRMCMGEGLARMELFLFLT 450
Query: 414 KILENFRVEWYGPPPKIIQTSI 435
IL+NF ++ P I T I
Sbjct: 451 TILQNFNLKSQVDPKDIDITPI 472
>AJ563378-3|CAD91347.1| 173|Homo sapiens hypothetical protein
protein.
Length = 173
Score = 69.7 bits (163), Expect = 2e-11
Identities = 39/114 (34%), Positives = 59/114 (51%), Gaps = 6/114 (5%)
Query: 306 YLKACIKETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEF 365
YL + ET+R+ PV R K+ I G +PKG V L +++ P EF
Sbjct: 26 YLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEF 85
Query: 366 IPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
PER+ + K D + P++ PFG G R+CIG R A + ++ L ++L+NF
Sbjct: 86 RPERF-SKKKDSI-----DPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 133
>AJ563378-2|CAD91647.1| 160|Homo sapiens cytochrome P450 protein.
Length = 160
Score = 69.7 bits (163), Expect = 2e-11
Identities = 39/114 (34%), Positives = 59/114 (51%), Gaps = 6/114 (5%)
Query: 306 YLKACIKETMRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEF 365
YL + ET+R+ PV R K+ I G +PKG V L +++ P EF
Sbjct: 13 YLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEF 72
Query: 366 IPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
PER+ + K D + P++ PFG G R+CIG R A + ++ L ++L+NF
Sbjct: 73 RPERF-SKKKDSI-----DPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 120
>AF372573-1|AAL69652.1| 495|Homo sapiens cytochrome P450 2F1
protein.
Length = 495
Score = 69.7 bits (163), Expect = 2e-11
Identities = 54/191 (28%), Positives = 87/191 (45%), Gaps = 19/191 (9%)
Query: 260 IMAT-DMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSKESKRY 306
+M T ++L G TV+ ++ K P+ Q +++EE+ + + Y
Sbjct: 293 LMTTHNLLFGGTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPY 352
Query: 307 LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEF 365
A I E R ++ NL R T++ G+ +PKG DV + + P EF
Sbjct: 353 TDAVIHEVQRFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEF 412
Query: 366 IPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYG 425
PE +L D N K P M PF G R C+G +A +E+ +LT IL++F ++ G
Sbjct: 413 NPEHFL-DANQSF---KKSPAFM-PFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLG 467
Query: 426 PPPKIIQTSIN 436
P I T ++
Sbjct: 468 APEDIDLTPLS 478
>AB080265-1|BAB85489.1| 502|Homo sapiens cytochrome P450 2J2
protein.
Length = 502
Score = 69.7 bits (163), Expect = 2e-11
Identities = 49/179 (27%), Positives = 81/179 (45%), Gaps = 19/179 (10%)
Query: 254 NEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSK 301
+EE D+ AG +T + ++ L A PE QEK++ E+ ++
Sbjct: 297 HEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQVEIDRVIGQGQQPSTAAR 356
Query: 302 ESKRYLKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYP 360
ES Y A I E RM ++ N+ R T + + GYH+PKG + L +
Sbjct: 357 ESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWA 416
Query: 361 RPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
P F P+ +L + + K F+ PF G R+C+G ++A E+ F T +++ F
Sbjct: 417 TPDTFNPDHFLENGQ----FKKREAFM--PFSIGKRACLGEQLARTELFIFFTSLMQKF 469
>M63871-1|AAA59984.1| 508|Homo sapiens CYP17 protein.
Length = 508
Score = 69.3 bits (162), Expect = 3e-11
Identities = 78/297 (26%), Positives = 130/297 (43%), Gaps = 44/297 (14%)
Query: 161 IRLNCFDPNLAENSPEKKLIECVHQ--IFNLSNQ--LDFQPSLWHIFSTPTYKKAMKMFQ 216
I L CF+ + PE +I+ ++ I NLS +D P L IF T +K +
Sbjct: 179 ISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWL-KIFPNKTLEKLKSHVK 237
Query: 217 LQEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLD--INEEYA--------------YI 260
++ DL +NK + N K + + D +L+ L+ +N + +I
Sbjct: 238 IRNDL----LNKILENY-KEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHI 292
Query: 261 MAT--DMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSKESKRY 306
+ T D+ AGV+T + + TL NP+ ++KL EE+ +
Sbjct: 293 LTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLL 352
Query: 307 LKACIKETMRMMPVVSGNLRRTTKEYNILG-YHVPKGIDVAFAHQDLSSMEEHYPRPTEF 365
L+A I+E +R+ PV + + +G + V KG +V L E+ + +P +F
Sbjct: 353 LEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQF 412
Query: 366 IPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
+PER+L L PFG G RSCIG +A E+ + +L+ F +E
Sbjct: 413 MPERFLNPAGTQLISPSVS---YLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466
>M61854-1|AAB59426.1| 490|Homo sapiens cytochrome protein.
Length = 490
Score = 69.3 bits (162), Expect = 3e-11
Identities = 50/193 (25%), Positives = 88/193 (45%), Gaps = 18/193 (9%)
Query: 256 EYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSKES 303
E I A D+L AG +T + ++ L L K+PE K++EE+ +
Sbjct: 285 ENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGH 344
Query: 304 KRYLKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRP 362
Y A + E R + ++ +L T + Y +PKG + + + + +P P
Sbjct: 345 MPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNP 404
Query: 363 TEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
F P +L + + + K++ F+ PF G R C+G +A +E+ FLT IL+NF ++
Sbjct: 405 EMFDPRHFLDEGGN---FKKSNYFM--PFSAGKRICVGEGLARMELFLFLTFILQNFNLK 459
Query: 423 WYGPPPKIIQTSI 435
P + T +
Sbjct: 460 SLIDPKDLDTTPV 472
>M31153-1|AAA52140.1| 508|Homo sapiens CYP17 protein.
Length = 508
Score = 69.3 bits (162), Expect = 3e-11
Identities = 78/297 (26%), Positives = 130/297 (43%), Gaps = 44/297 (14%)
Query: 161 IRLNCFDPNLAENSPEKKLIECVHQ--IFNLSNQ--LDFQPSLWHIFSTPTYKKAMKMFQ 216
I L CF+ + PE +I+ ++ I NLS +D P L IF T +K +
Sbjct: 179 ISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWL-KIFPNKTLEKLKSHVK 237
Query: 217 LQEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLD--INEEYA--------------YI 260
++ DL +NK + N K + + D +L+ L+ +N + +I
Sbjct: 238 IRNDL----LNKILENY-KEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHI 292
Query: 261 MAT--DMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSKESKRY 306
+ T D+ AGV+T + + TL NP+ ++KL EE+ +
Sbjct: 293 LTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLL 352
Query: 307 LKACIKETMRMMPVVSGNLRRTTKEYNILG-YHVPKGIDVAFAHQDLSSMEEHYPRPTEF 365
L+A I+E +R+ PV + + +G + V KG +V L E+ + +P +F
Sbjct: 353 LEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQF 412
Query: 366 IPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
+PER+L L PFG G RSCIG +A E+ + +L+ F +E
Sbjct: 413 MPERFLNPAGTQLISPSVS---YLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466
>M19489-1|AAA36405.1| 508|Homo sapiens CYP17 protein.
Length = 508
Score = 69.3 bits (162), Expect = 3e-11
Identities = 78/297 (26%), Positives = 130/297 (43%), Gaps = 44/297 (14%)
Query: 161 IRLNCFDPNLAENSPEKKLIECVHQ--IFNLSNQ--LDFQPSLWHIFSTPTYKKAMKMFQ 216
I L CF+ + PE +I+ ++ I NLS +D P L IF T +K +
Sbjct: 179 ISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWL-KIFPNKTLEKLKSHVK 237
Query: 217 LQEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLD--INEEYA--------------YI 260
++ DL +NK + N K + + D +L+ L+ +N + +I
Sbjct: 238 IRNDL----LNKILENY-KEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHI 292
Query: 261 MAT--DMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSKESKRY 306
+ T D+ AGV+T + + TL NP+ ++KL EE+ +
Sbjct: 293 LTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLL 352
Query: 307 LKACIKETMRMMPVVSGNLRRTTKEYNILG-YHVPKGIDVAFAHQDLSSMEEHYPRPTEF 365
L+A I+E +R+ PV + + +G + V KG +V L E+ + +P +F
Sbjct: 353 LEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQF 412
Query: 366 IPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
+PER+L L PFG G RSCIG +A E+ + +L+ F +E
Sbjct: 413 MPERFLNPAGTQLISPSVS---YLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466
>M14564-1|AAA52151.1| 508|Homo sapiens CYP17 protein.
Length = 508
Score = 69.3 bits (162), Expect = 3e-11
Identities = 78/297 (26%), Positives = 130/297 (43%), Gaps = 44/297 (14%)
Query: 161 IRLNCFDPNLAENSPEKKLIECVHQ--IFNLSNQ--LDFQPSLWHIFSTPTYKKAMKMFQ 216
I L CF+ + PE +I+ ++ I NLS +D P L IF T +K +
Sbjct: 179 ISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWL-KIFPNKTLEKLKSHVK 237
Query: 217 LQEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLD--INEEYA--------------YI 260
++ DL +NK + N K + + D +L+ L+ +N + +I
Sbjct: 238 IRNDL----LNKILENY-KEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHI 292
Query: 261 MAT--DMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSKESKRY 306
+ T D+ AGV+T + + TL NP+ ++KL EE+ +
Sbjct: 293 LTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLL 352
Query: 307 LKACIKETMRMMPVVSGNLRRTTKEYNILG-YHVPKGIDVAFAHQDLSSMEEHYPRPTEF 365
L+A I+E +R+ PV + + +G + V KG +V L E+ + +P +F
Sbjct: 353 LEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQF 412
Query: 366 IPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
+PER+L L PFG G RSCIG +A E+ + +L+ F +E
Sbjct: 413 MPERFLNPAGTQLISPSVS---YLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466
>L39102-1|AAL31348.1| 217|Homo sapiens S-mephenytoin 4-hydroxylase
protein.
Length = 217
Score = 69.3 bits (162), Expect = 3e-11
Identities = 50/193 (25%), Positives = 88/193 (45%), Gaps = 18/193 (9%)
Query: 256 EYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSKES 303
E I A D+L AG +T + ++ L L K+PE K++EE+ +
Sbjct: 12 ENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGH 71
Query: 304 KRYLKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRP 362
Y A + E R + ++ +L T + Y +PKG + + + + +P P
Sbjct: 72 MPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNP 131
Query: 363 TEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
F P +L + + + K++ F+ PF G R C+G +A +E+ FLT IL+NF ++
Sbjct: 132 EMFDPRHFLDEGGN---FKKSNYFM--PFSAGKRICVGEGLARMELFLFLTFILQNFNLK 186
Query: 423 WYGPPPKIIQTSI 435
P + T +
Sbjct: 187 SLIDPKDLDTTPV 199
>L07093-1|AAA36660.1| 468|Homo sapiens cytochrome P450 protein.
Length = 468
Score = 69.3 bits (162), Expect = 3e-11
Identities = 50/193 (25%), Positives = 88/193 (45%), Gaps = 18/193 (9%)
Query: 256 EYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSKES 303
E I A D+L AG +T + ++ L L K+PE K++EE+ +
Sbjct: 263 ENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGH 322
Query: 304 KRYLKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRP 362
Y A + E R + ++ +L T + Y +PKG + + + + +P P
Sbjct: 323 MPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNP 382
Query: 363 TEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
F P +L + + + K++ F+ PF G R C+G +A +E+ FLT IL+NF ++
Sbjct: 383 EMFDPRHFLDEGGN---FKKSNYFM--PFSAGKRICVGEGLARMELFLFLTFILQNFNLK 437
Query: 423 WYGPPPKIIQTSI 435
P + T +
Sbjct: 438 SLIDPKDLDTTPV 450
>J02906-1|AAA52156.1| 491|Homo sapiens CYP2F1 protein.
Length = 491
Score = 69.3 bits (162), Expect = 3e-11
Identities = 54/191 (28%), Positives = 87/191 (45%), Gaps = 19/191 (9%)
Query: 260 IMAT-DMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSKESKRY 306
+M T ++L G TV+ ++ K P+ Q +++EE+ + + Y
Sbjct: 289 LMTTHNLLFGGTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPY 348
Query: 307 LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEF 365
A I E R ++ NL R T++ G+ +PKG DV + + P EF
Sbjct: 349 TDAVIHEVQRFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEF 408
Query: 366 IPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYG 425
PE +L D N K P M PF G R C+G +A +E+ +LT IL++F ++ G
Sbjct: 409 NPEHFL-DANQSF---KKSPAFM-PFSAGRRLCLGELLARMELFLYLTAILQSFSLQPLG 463
Query: 426 PPPKIIQTSIN 436
P I T ++
Sbjct: 464 APEDIDLTPLS 474
>DQ530598-1|ABF50972.1| 508|Homo sapiens cytochrome P450, family
17, subfamily A, polypeptide 1 protein.
Length = 508
Score = 69.3 bits (162), Expect = 3e-11
Identities = 78/297 (26%), Positives = 130/297 (43%), Gaps = 44/297 (14%)
Query: 161 IRLNCFDPNLAENSPEKKLIECVHQ--IFNLSNQ--LDFQPSLWHIFSTPTYKKAMKMFQ 216
I L CF+ + PE +I+ ++ I NLS +D P L IF T +K +
Sbjct: 179 ISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWL-KIFPNKTLEKLKSHVK 237
Query: 217 LQEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLD--INEEYA--------------YI 260
++ DL +NK + N K + + D +L+ L+ +N + +I
Sbjct: 238 IRNDL----LNKILENY-KEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHI 292
Query: 261 MAT--DMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSKESKRY 306
+ T D+ AGV+T + + TL NP+ ++KL EE+ +
Sbjct: 293 LTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLL 352
Query: 307 LKACIKETMRMMPVVSGNLRRTTKEYNILG-YHVPKGIDVAFAHQDLSSMEEHYPRPTEF 365
L+A I+E +R+ PV + + +G + V KG +V L E+ + +P +F
Sbjct: 353 LEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQF 412
Query: 366 IPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
+PER+L L PFG G RSCIG +A E+ + +L+ F +E
Sbjct: 413 MPERFLNPAGTQLISPSVS---YLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466
>BT020000-1|AAV38803.1| 508|Homo sapiens cytochrome P450, family
17, subfamily A, polypeptide 1 protein.
Length = 508
Score = 69.3 bits (162), Expect = 3e-11
Identities = 78/297 (26%), Positives = 130/297 (43%), Gaps = 44/297 (14%)
Query: 161 IRLNCFDPNLAENSPEKKLIECVHQ--IFNLSNQ--LDFQPSLWHIFSTPTYKKAMKMFQ 216
I L CF+ + PE +I+ ++ I NLS +D P L IF T +K +
Sbjct: 179 ISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWL-KIFPNKTLEKLKSHVK 237
Query: 217 LQEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLD--INEEYA--------------YI 260
++ DL +NK + N K + + D +L+ L+ +N + +I
Sbjct: 238 IRNDL----LNKILENY-KEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHI 292
Query: 261 MAT--DMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSKESKRY 306
+ T D+ AGV+T + + TL NP+ ++KL EE+ +
Sbjct: 293 LTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLL 352
Query: 307 LKACIKETMRMMPVVSGNLRRTTKEYNILG-YHVPKGIDVAFAHQDLSSMEEHYPRPTEF 365
L+A I+E +R+ PV + + +G + V KG +V L E+ + +P +F
Sbjct: 353 LEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQF 412
Query: 366 IPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
+PER+L L PFG G RSCIG +A E+ + +L+ F +E
Sbjct: 413 MPERFLNPAGTQLISPSVS---YLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466
>BC063388-1|AAH63388.1| 508|Homo sapiens cytochrome P450, family
17, subfamily A, polypeptide 1 protein.
Length = 508
Score = 69.3 bits (162), Expect = 3e-11
Identities = 78/297 (26%), Positives = 130/297 (43%), Gaps = 44/297 (14%)
Query: 161 IRLNCFDPNLAENSPEKKLIECVHQ--IFNLSNQ--LDFQPSLWHIFSTPTYKKAMKMFQ 216
I L CF+ + PE +I+ ++ I NLS +D P L IF T +K +
Sbjct: 179 ISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWL-KIFPNKTLEKLKSHVK 237
Query: 217 LQEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLD--INEEYA--------------YI 260
++ DL +NK + N K + + D +L+ L+ +N + +I
Sbjct: 238 IRNDL----LNKILENY-KEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHI 292
Query: 261 MAT--DMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSKESKRY 306
+ T D+ AGV+T + + TL NP+ ++KL EE+ +
Sbjct: 293 LTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLL 352
Query: 307 LKACIKETMRMMPVVSGNLRRTTKEYNILG-YHVPKGIDVAFAHQDLSSMEEHYPRPTEF 365
L+A I+E +R+ PV + + +G + V KG +V L E+ + +P +F
Sbjct: 353 LEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQF 412
Query: 366 IPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
+PER+L L PFG G RSCIG +A E+ + +L+ F +E
Sbjct: 413 MPERFLNPAGTQLISPSVS---YLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466
>BC062997-1|AAH62997.1| 508|Homo sapiens cytochrome P450, family
17, subfamily A, polypeptide 1 protein.
Length = 508
Score = 69.3 bits (162), Expect = 3e-11
Identities = 78/297 (26%), Positives = 130/297 (43%), Gaps = 44/297 (14%)
Query: 161 IRLNCFDPNLAENSPEKKLIECVHQ--IFNLSNQ--LDFQPSLWHIFSTPTYKKAMKMFQ 216
I L CF+ + PE +I+ ++ I NLS +D P L IF T +K +
Sbjct: 179 ISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWL-KIFPNKTLEKLKSHVK 237
Query: 217 LQEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLD--INEEYA--------------YI 260
++ DL +NK + N K + + D +L+ L+ +N + +I
Sbjct: 238 IRNDL----LNKILENY-KEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHI 292
Query: 261 MAT--DMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSKESKRY 306
+ T D+ AGV+T + + TL NP+ ++KL EE+ +
Sbjct: 293 LTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLL 352
Query: 307 LKACIKETMRMMPVVSGNLRRTTKEYNILG-YHVPKGIDVAFAHQDLSSMEEHYPRPTEF 365
L+A I+E +R+ PV + + +G + V KG +V L E+ + +P +F
Sbjct: 353 LEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQF 412
Query: 366 IPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
+PER+L L PFG G RSCIG +A E+ + +L+ F +E
Sbjct: 413 MPERFLNPAGTQLISPSVS---YLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466
>AY796203-1|AAV41877.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 19 protein.
Length = 490
Score = 69.3 bits (162), Expect = 3e-11
Identities = 50/193 (25%), Positives = 88/193 (45%), Gaps = 18/193 (9%)
Query: 256 EYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSKES 303
E I A D+L AG +T + ++ L L K+PE K++EE+ +
Sbjct: 285 ENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGH 344
Query: 304 KRYLKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRP 362
Y A + E R + ++ +L T + Y +PKG + + + + +P P
Sbjct: 345 MPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNP 404
Query: 363 TEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
F P +L + + + K++ F+ PF G R C+G +A +E+ FLT IL+NF ++
Sbjct: 405 EMFDPRHFLDEGGN---FKKSNYFM--PFSAGKRICVGEGLARMELFLFLTFILQNFNLK 459
Query: 423 WYGPPPKIIQTSI 435
P + T +
Sbjct: 460 SLIDPKDLDTTPV 472
>AL583836-2|CAH74068.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 19 protein.
Length = 490
Score = 69.3 bits (162), Expect = 3e-11
Identities = 50/193 (25%), Positives = 88/193 (45%), Gaps = 18/193 (9%)
Query: 256 EYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSKES 303
E I A D+L AG +T + ++ L L K+PE K++EE+ +
Sbjct: 285 ENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGH 344
Query: 304 KRYLKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRP 362
Y A + E R + ++ +L T + Y +PKG + + + + +P P
Sbjct: 345 MPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNP 404
Query: 363 TEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
F P +L + + + K++ F+ PF G R C+G +A +E+ FLT IL+NF ++
Sbjct: 405 EMFDPRHFLDEGGN---FKKSNYFM--PFSAGKRICVGEGLARMELFLFLTFILQNFNLK 459
Query: 423 WYGPPPKIIQTSI 435
P + T +
Sbjct: 460 SLIDPKDLDTTPV 472
>AL358790-3|CAI52498.1| 508|Homo sapiens cytochrome P450, family
17, subfamily A, polypeptide 1 protein.
Length = 508
Score = 69.3 bits (162), Expect = 3e-11
Identities = 78/297 (26%), Positives = 130/297 (43%), Gaps = 44/297 (14%)
Query: 161 IRLNCFDPNLAENSPEKKLIECVHQ--IFNLSNQ--LDFQPSLWHIFSTPTYKKAMKMFQ 216
I L CF+ + PE +I+ ++ I NLS +D P L IF T +K +
Sbjct: 179 ISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWL-KIFPNKTLEKLKSHVK 237
Query: 217 LQEDLSKYFINKAMRNINKNENKPDEQKGVLEKLLD--INEEYA--------------YI 260
++ DL +NK + N K + + D +L+ L+ +N + +I
Sbjct: 238 IRNDL----LNKILENY-KEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHI 292
Query: 261 MAT--DMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSKESKRY 306
+ T D+ AGV+T + + TL NP+ ++KL EE+ +
Sbjct: 293 LTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLL 352
Query: 307 LKACIKETMRMMPVVSGNLRRTTKEYNILG-YHVPKGIDVAFAHQDLSSMEEHYPRPTEF 365
L+A I+E +R+ PV + + +G + V KG +V L E+ + +P +F
Sbjct: 353 LEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQF 412
Query: 366 IPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
+PER+L L PFG G RSCIG +A E+ + +L+ F +E
Sbjct: 413 MPERFLNPAGTQLISPSVS---YLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466
>AL133513-2|CAH73444.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 19 protein.
Length = 490
Score = 69.3 bits (162), Expect = 3e-11
Identities = 50/193 (25%), Positives = 88/193 (45%), Gaps = 18/193 (9%)
Query: 256 EYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSKES 303
E I A D+L AG +T + ++ L L K+PE K++EE+ +
Sbjct: 285 ENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGH 344
Query: 304 KRYLKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRP 362
Y A + E R + ++ +L T + Y +PKG + + + + +P P
Sbjct: 345 MPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNP 404
Query: 363 TEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
F P +L + + + K++ F+ PF G R C+G +A +E+ FLT IL+NF ++
Sbjct: 405 EMFDPRHFLDEGGN---FKKSNYFM--PFSAGKRICVGEGLARMELFLFLTFILQNFNLK 459
Query: 423 WYGPPPKIIQTSI 435
P + T +
Sbjct: 460 SLIDPKDLDTTPV 472
>AK223510-1|BAD97230.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 18 variant protein.
Length = 490
Score = 69.3 bits (162), Expect = 3e-11
Identities = 66/262 (25%), Positives = 114/262 (43%), Gaps = 21/262 (8%)
Query: 188 NLSNQLDFQPSLWH-IFSTPTYKKAMKMFQLQEDLSKYFINKAMRNINKNENKPDEQKGV 246
N +D+ P + I Y K+ + +++E +N A I+ K +++K
Sbjct: 218 NFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHN 277
Query: 247 LEKLLDINEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-------- 298
+ + A + TDM AG +T + ++ L L K PE K++EE+
Sbjct: 278 QQSEFTVESLIATV--TDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNR 335
Query: 299 ----MSKESKRYLKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLS 353
+ Y A + E R + ++ NL T + Y +PKG + + +
Sbjct: 336 SPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVL 395
Query: 354 SMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLT 413
++ +P P F P +L DK+ + K+ F+ PF G R C+G +A +E+ FLT
Sbjct: 396 HNDKEFPNPEMFDPGHFL-DKSGN--FKKSDYFM--PFSAGKRMCMGEGLARMELFLFLT 450
Query: 414 KILENFRVEWYGPPPKIIQTSI 435
IL+NF ++ P I T I
Sbjct: 451 TILQNFNLKSKVDPKDIDITPI 472
>M21939-1|AAA52158.1| 485|Homo sapiens CYP2C protein.
Length = 485
Score = 68.9 bits (161), Expect = 3e-11
Identities = 49/187 (26%), Positives = 85/187 (45%), Gaps = 18/187 (9%)
Query: 262 ATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSKESKRYLKA 309
A D+ AG +T + ++ L L K+PE K++EE+ + Y A
Sbjct: 286 AVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDA 345
Query: 310 CIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPE 368
+ E R + ++ +L T + Y +PKG + + + + +P P F P
Sbjct: 346 VVHEVQRCIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPH 405
Query: 369 RWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPP 428
+L D+ D + K+ F+ PF G R C+G +A +E+ FLT IL+NF ++ P
Sbjct: 406 HFL-DEGDN--FKKSKYFM--PFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPK 460
Query: 429 KIIQTSI 435
+ T +
Sbjct: 461 NLDTTPV 467
>M15331-1|AAA52157.1| 485|Homo sapiens CYP2C protein.
Length = 485
Score = 68.9 bits (161), Expect = 3e-11
Identities = 49/187 (26%), Positives = 85/187 (45%), Gaps = 18/187 (9%)
Query: 262 ATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSKESKRYLKA 309
A D+ AG +T + ++ L L K+PE K++EE+ + Y A
Sbjct: 286 AVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDA 345
Query: 310 CIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPE 368
+ E R + ++ +L T + Y +PKG + + + + +P P F P
Sbjct: 346 VVHEVQRCIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPH 405
Query: 369 RWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPP 428
+L D+ D + K+ F+ PF G R C+G +A +E+ FLT IL+NF ++ P
Sbjct: 406 HFL-DEGDN--FKKSKYFM--PFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPK 460
Query: 429 KIIQTSI 435
+ T +
Sbjct: 461 NLDTTPV 467
>J02843-1|AAA52155.1| 493|Homo sapiens protein ( Human cytochrome
P450IIE1 (ethanol-inducible) gene, complete cds. ).
Length = 493
Score = 68.9 bits (161), Expect = 3e-11
Identities = 47/176 (26%), Positives = 79/176 (44%), Gaps = 18/176 (10%)
Query: 260 IMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE------------VMSKESKRYL 307
+ D+ AG +T + ++ L + K PE +EKL EE + ++ Y+
Sbjct: 291 VTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYM 350
Query: 308 KACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFI 366
A + E R + +V NL T++ GY +PKG V + + +P P +F
Sbjct: 351 DAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFK 410
Query: 367 PERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
PE +L ++N Y PF G R C G +A +E+ L IL++F ++
Sbjct: 411 PEHFL-NENGKFKYSD----YFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLK 461
>J02625-1|AAA35743.1| 493|Homo sapiens protein ( Human cytochrome
P-450j mRNA, complete cds. ).
Length = 493
Score = 68.9 bits (161), Expect = 3e-11
Identities = 47/176 (26%), Positives = 79/176 (44%), Gaps = 18/176 (10%)
Query: 260 IMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE------------VMSKESKRYL 307
+ D+ AG +T + ++ L + K PE +EKL EE + ++ Y+
Sbjct: 291 VTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYM 350
Query: 308 KACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFI 366
A + E R + +V NL T++ GY +PKG V + + +P P +F
Sbjct: 351 DAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFK 410
Query: 367 PERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
PE +L ++N Y PF G R C G +A +E+ L IL++F ++
Sbjct: 411 PEHFL-NENGKFKYSD----YFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLK 461
>DQ515958-1|ABF47105.1| 493|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 1 protein.
Length = 493
Score = 68.9 bits (161), Expect = 3e-11
Identities = 47/176 (26%), Positives = 79/176 (44%), Gaps = 18/176 (10%)
Query: 260 IMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE------------VMSKESKRYL 307
+ D+ AG +T + ++ L + K PE +EKL EE + ++ Y+
Sbjct: 291 VTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYM 350
Query: 308 KACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFI 366
A + E R + +V NL T++ GY +PKG V + + +P P +F
Sbjct: 351 DAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFK 410
Query: 367 PERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
PE +L ++N Y PF G R C G +A +E+ L IL++F ++
Sbjct: 411 PEHFL-NENGKFKYSD----YFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLK 461
>DQ149222-1|AAZ77710.1| 493|Homo sapiens cytochrome P450 2E1
protein.
Length = 493
Score = 68.9 bits (161), Expect = 3e-11
Identities = 47/176 (26%), Positives = 79/176 (44%), Gaps = 18/176 (10%)
Query: 260 IMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE------------VMSKESKRYL 307
+ D+ AG +T + ++ L + K PE +EKL EE + ++ Y+
Sbjct: 291 VTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYM 350
Query: 308 KACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFI 366
A + E R + +V NL T++ GY +PKG V + + +P P +F
Sbjct: 351 DAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFK 410
Query: 367 PERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
PE +L ++N Y PF G R C G +A +E+ L IL++F ++
Sbjct: 411 PEHFL-NENGKFKYSD----YFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLK 461
>AL161645-2|CAH70047.1| 493|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 1 protein.
Length = 493
Score = 68.9 bits (161), Expect = 3e-11
Identities = 47/176 (26%), Positives = 79/176 (44%), Gaps = 18/176 (10%)
Query: 260 IMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE------------VMSKESKRYL 307
+ D+ AG +T + ++ L + K PE +EKL EE + ++ Y+
Sbjct: 291 VTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYM 350
Query: 308 KACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFI 366
A + E R + +V NL T++ GY +PKG V + + +P P +F
Sbjct: 351 DAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFK 410
Query: 367 PERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
PE +L ++N Y PF G R C G +A +E+ L IL++F ++
Sbjct: 411 PEHFL-NENGKFKYSD----YFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLK 461
>AF182276-1|AAF13601.1| 493|Homo sapiens cytochrome P450-2E1
protein.
Length = 493
Score = 68.9 bits (161), Expect = 3e-11
Identities = 47/176 (26%), Positives = 79/176 (44%), Gaps = 18/176 (10%)
Query: 260 IMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE------------VMSKESKRYL 307
+ D+ AG +T + ++ L + K PE +EKL EE + ++ Y+
Sbjct: 291 VTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYM 350
Query: 308 KACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFI 366
A + E R + +V NL T++ GY +PKG V + + +P P +F
Sbjct: 351 DAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFK 410
Query: 367 PERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
PE +L ++N Y PF G R C G +A +E+ L IL++F ++
Sbjct: 411 PEHFL-NENGKFKYSD----YFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLK 461
>AF084225-1|AAD13753.1| 462|Homo sapiens cytochrome P450 2E1
protein.
Length = 462
Score = 68.9 bits (161), Expect = 3e-11
Identities = 47/176 (26%), Positives = 79/176 (44%), Gaps = 18/176 (10%)
Query: 260 IMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE------------VMSKESKRYL 307
+ D+ AG +T + ++ L + K PE +EKL EE + ++ Y+
Sbjct: 260 VTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYM 319
Query: 308 KACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFI 366
A + E R + +V NL T++ GY +PKG V + + +P P +F
Sbjct: 320 DAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFK 379
Query: 367 PERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
PE +L ++N Y PF G R C G +A +E+ L IL++F ++
Sbjct: 380 PEHFL-NENGKFKYSD----YFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLK 430
>U22029-1|AAB40520.1| 494|Homo sapiens cytochrome P450 protein.
Length = 494
Score = 68.5 bits (160), Expect = 5e-11
Identities = 55/205 (26%), Positives = 99/205 (48%), Gaps = 23/205 (11%)
Query: 260 IMAT-DMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV-----MSKESK-------RY 306
+M+T ++ +AG +TV+ ++ L K+PE + K+ EE+ +++ K Y
Sbjct: 292 MMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPY 351
Query: 307 LKACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEF 365
++A I E R V+ +L RR K+ + +PKG +V + + P +F
Sbjct: 352 MEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDLRFFSNPRDF 411
Query: 366 IPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYG 425
P+ +L +K + K FV PF R+C G +A +E+ F T +++NFR++
Sbjct: 412 NPQHFLGEKGQ---FKKRDAFV--PFSIRKRNCFGEGLARMELFLFFTTVMQNFRLK-SS 465
Query: 426 PPPKIIQTS---INYFTGPFNFVFN 447
PK I S + + T P N+ +
Sbjct: 466 QSPKDIDVSPKHVVFATIPRNYTMS 490
>M61858-1|AAA52145.1| 370|Homo sapiens CYP2C17 protein.
Length = 370
Score = 68.5 bits (160), Expect = 5e-11
Identities = 48/186 (25%), Positives = 85/186 (45%), Gaps = 18/186 (9%)
Query: 263 TDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSKESKRYLKAC 310
TDM AG +T + ++ L L K+PE K++EE+ + Y A
Sbjct: 172 TDMFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRSHMPYTDAV 231
Query: 311 IKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPER 369
+ E R + ++ +L T + Y +PKG + + + + +P P F P
Sbjct: 232 VHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRH 291
Query: 370 WLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPPK 429
+L + + + K++ F+ PF G R C+G +A +E+ FLT IL+NF ++ P
Sbjct: 292 FLDEGGN---FKKSNYFM--PFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKD 346
Query: 430 IIQTSI 435
+ T +
Sbjct: 347 LDTTPV 352
>BX538127-1|CAD98029.1| 310|Homo sapiens hypothetical protein
protein.
Length = 310
Score = 68.5 bits (160), Expect = 5e-11
Identities = 53/186 (28%), Positives = 85/186 (45%), Gaps = 18/186 (9%)
Query: 263 TDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSKESKRYLKAC 310
TDM AG +T + ++ L L K PE K++EE+ + Y A
Sbjct: 112 TDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAV 171
Query: 311 IKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPER 369
+ E R + ++ NL T + Y +PKG + + + ++ +P P F P
Sbjct: 172 VHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGH 231
Query: 370 WLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPPK 429
+L DK+ + K+ F+ PF G R C+G +A +E+ FLT IL+NF ++ P
Sbjct: 232 FL-DKSGN--FKKSDYFM--PFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKD 286
Query: 430 IIQTSI 435
I T I
Sbjct: 287 IDITPI 292
>BC096260-1|AAH96260.1| 431|Homo sapiens CYP2C18 protein protein.
Length = 431
Score = 68.5 bits (160), Expect = 5e-11
Identities = 53/186 (28%), Positives = 85/186 (45%), Gaps = 18/186 (9%)
Query: 263 TDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSKESKRYLKAC 310
TDM AG +T + ++ L L K PE K++EE+ + Y A
Sbjct: 233 TDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAV 292
Query: 311 IKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPER 369
+ E R + ++ NL T + Y +PKG + + + ++ +P P F P
Sbjct: 293 VHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGH 352
Query: 370 WLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPPK 429
+L DK+ + K+ F+ PF G R C+G +A +E+ FLT IL+NF ++ P
Sbjct: 353 FL-DKSGN--FKKSDYFM--PFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKD 407
Query: 430 IIQTSI 435
I T I
Sbjct: 408 IDITPI 413
>Y00498-1|CAA68550.1| 490|Homo sapiens IIC2 protein.
Length = 490
Score = 67.7 bits (158), Expect = 8e-11
Identities = 56/201 (27%), Positives = 88/201 (43%), Gaps = 24/201 (11%)
Query: 235 KNENKPDEQKGVLEKLLDINEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKL 294
K E + D QK + N E D+ VAG +T + ++ L L K+PE K+
Sbjct: 270 KMEQEKDNQKS------EFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKV 323
Query: 295 REEV------------MSKESKRYLKACIKETMRMMPVV-SGNLRRTTKEYNILGYHVPK 341
+EE+ + Y A + E R +V +G T + Y +PK
Sbjct: 324 QEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPK 383
Query: 342 GIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGR 401
G + + ++ +P P F P +L DKN + K+ F+ PF G R C G
Sbjct: 384 GTTIMALLTSVLHDDKEFPNPNIFDPGHFL-DKNGN--FKKSDYFM--PFSAGKRICAGE 438
Query: 402 RIAELEIETFLTKILENFRVE 422
+A +E+ FLT IL+NF ++
Sbjct: 439 GLARMELFLFLTTILQNFNLK 459
>S46963-1|AAB23864.2| 477|Homo sapiens cytochrome P-450 protein.
Length = 477
Score = 67.7 bits (158), Expect = 8e-11
Identities = 47/187 (25%), Positives = 84/187 (44%), Gaps = 18/187 (9%)
Query: 262 ATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSKESKRYLKA 309
A D+ AG +T + ++ L L K+PE K++EE+ + Y A
Sbjct: 278 AVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDA 337
Query: 310 CIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPE 368
+ E R + ++ +L T + Y +PKG + + + + +P P F P
Sbjct: 338 VVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPH 397
Query: 369 RWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPP 428
+L + + + K+ F+ PF G R C+G +A +E+ FLT IL+NF ++ P
Sbjct: 398 HFLDEGGN---FKKSKYFM--PFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPK 452
Query: 429 KIIQTSI 435
+ T +
Sbjct: 453 NLDTTPV 459
>M21942-1|AAA52161.1| 462|Homo sapiens CYP2C protein.
Length = 462
Score = 67.7 bits (158), Expect = 8e-11
Identities = 56/201 (27%), Positives = 88/201 (43%), Gaps = 24/201 (11%)
Query: 235 KNENKPDEQKGVLEKLLDINEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKL 294
K E + D QK + N E D+ VAG +T + ++ L L K+PE K+
Sbjct: 242 KMEQEKDNQKS------EFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKV 295
Query: 295 REEV------------MSKESKRYLKACIKETMRMMPVV-SGNLRRTTKEYNILGYHVPK 341
+EE+ + Y A + E R +V +G T + Y +PK
Sbjct: 296 QEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPK 355
Query: 342 GIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGR 401
G + + ++ +P P F P +L DKN + K+ F+ PF G R C G
Sbjct: 356 GTTIMALLTSVLHDDKEFPNPNIFDPGHFL-DKNGN--FKKSDYFM--PFSAGKRICAGE 410
Query: 402 RIAELEIETFLTKILENFRVE 422
+A +E+ FLT IL+NF ++
Sbjct: 411 GLARMELFLFLTTILQNFNLK 431
>M21940-1|AAA52159.1| 383|Homo sapiens CYP2C protein.
Length = 383
Score = 67.7 bits (158), Expect = 8e-11
Identities = 47/187 (25%), Positives = 84/187 (44%), Gaps = 18/187 (9%)
Query: 262 ATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSKESKRYLKA 309
A D+ AG +T + ++ L L K+PE K++EE+ + Y A
Sbjct: 184 AVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDA 243
Query: 310 CIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPE 368
+ E R + ++ +L T + Y +PKG + + + + +P P F P
Sbjct: 244 VVHEVQRCIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPH 303
Query: 369 RWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPP 428
+L + + + K+ F+ PF G R C+G +A +E+ FLT IL+NF ++ P
Sbjct: 304 HFLDEGGN---FKKSKYFM--PFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPK 358
Query: 429 KIIQTSI 435
+ T +
Sbjct: 359 NLDTTPV 365
>M17397-1|AAA35739.1| 490|Homo sapiens protein ( Human cytochrome
P-450 1 functional form mRNA, complete cds. ).
Length = 490
Score = 67.7 bits (158), Expect = 8e-11
Identities = 56/201 (27%), Positives = 88/201 (43%), Gaps = 24/201 (11%)
Query: 235 KNENKPDEQKGVLEKLLDINEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKL 294
K E + D QK + N E D+ VAG +T + ++ L L K+PE K+
Sbjct: 270 KMEQEKDNQKS------EFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKV 323
Query: 295 REEV------------MSKESKRYLKACIKETMRMMPVV-SGNLRRTTKEYNILGYHVPK 341
+EE+ + Y A + E R +V +G T + Y +PK
Sbjct: 324 QEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPK 383
Query: 342 GIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGR 401
G + + ++ +P P F P +L DKN + K+ F+ PF G R C G
Sbjct: 384 GTTIMALLTSVLHDDKEFPNPNIFDPGHFL-DKNGN--FKKSDYFM--PFSAGKRICAGE 438
Query: 402 RIAELEIETFLTKILENFRVE 422
+A +E+ FLT IL+NF ++
Sbjct: 439 GLARMELFLFLTTILQNFNLK 459
>D00173-1|BAA00123.1| 487|Homo sapiens cytochrome P-450 protein.
Length = 487
Score = 67.7 bits (158), Expect = 8e-11
Identities = 47/187 (25%), Positives = 84/187 (44%), Gaps = 18/187 (9%)
Query: 262 ATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSKESKRYLKA 309
A D+ AG +T + ++ L L K+PE K++EE+ + Y A
Sbjct: 288 AVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDA 347
Query: 310 CIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPE 368
+ E R + ++ +L T + Y +PKG + + + + +P P F P
Sbjct: 348 VVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPH 407
Query: 369 RWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPP 428
+L + + + K+ F+ PF G R C+G +A +E+ FLT IL+NF ++ P
Sbjct: 408 HFLDEGGN---FKKSKYFM--PFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPK 462
Query: 429 KIIQTSI 435
+ T +
Sbjct: 463 NLDTTPV 469
>BC125054-1|AAI25055.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 67.7 bits (158), Expect = 8e-11
Identities = 47/187 (25%), Positives = 84/187 (44%), Gaps = 18/187 (9%)
Query: 262 ATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSKESKRYLKA 309
A D+ AG +T + ++ L L K+PE K++EE+ + Y A
Sbjct: 291 AVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDA 350
Query: 310 CIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPE 368
+ E R + ++ +L T + Y +PKG + + + + +P P F P
Sbjct: 351 VVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPH 410
Query: 369 RWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPP 428
+L + + + K+ F+ PF G R C+G +A +E+ FLT IL+NF ++ P
Sbjct: 411 HFLDEGGN---FKKSKYFM--PFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPK 465
Query: 429 KIIQTSI 435
+ T +
Sbjct: 466 NLDTTPV 472
>BC067435-1|AAH67435.1| 493|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 1 protein.
Length = 493
Score = 67.7 bits (158), Expect = 8e-11
Identities = 47/176 (26%), Positives = 78/176 (44%), Gaps = 18/176 (10%)
Query: 260 IMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREE------------VMSKESKRYL 307
+ D+ AG +T + ++ L + K PE +EKL EE + ++ Y+
Sbjct: 291 VTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYM 350
Query: 308 KACIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFI 366
A + E R + +V NL T++ GY +PKG V + + +P P +F
Sbjct: 351 DAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFK 410
Query: 367 PERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVE 422
PE +L ++N Y PF G R C G +A E+ L IL++F ++
Sbjct: 411 PEHFL-NENGKFKYSD----YFKPFSTGKRVCAGEGLARTELFLLLCAILQHFNLK 461
>BC020596-1|AAH20596.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 8 protein.
Length = 490
Score = 67.7 bits (158), Expect = 8e-11
Identities = 56/201 (27%), Positives = 88/201 (43%), Gaps = 24/201 (11%)
Query: 235 KNENKPDEQKGVLEKLLDINEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKL 294
K E + D QK + N E D+ VAG +T + ++ L L K+PE K+
Sbjct: 270 KMEQEKDNQKS------EFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKV 323
Query: 295 REEV------------MSKESKRYLKACIKETMRMMPVV-SGNLRRTTKEYNILGYHVPK 341
+EE+ + Y A + E R +V +G T + Y +PK
Sbjct: 324 QEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPK 383
Query: 342 GIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGR 401
G + + ++ +P P F P +L DKN + K+ F+ PF G R C G
Sbjct: 384 GTTIMALLTSVLHDDKEFPNPNIFDPGHFL-DKNGN--FKKSDYFM--PFSAGKRICAGE 438
Query: 402 RIAELEIETFLTKILENFRVE 422
+A +E+ FLT IL+NF ++
Sbjct: 439 GLARMELFLFLTTILQNFNLK 459
>AY702706-1|AAT94065.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 67.7 bits (158), Expect = 8e-11
Identities = 47/187 (25%), Positives = 84/187 (44%), Gaps = 18/187 (9%)
Query: 262 ATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSKESKRYLKA 309
A D+ AG +T + ++ L L K+PE K++EE+ + Y A
Sbjct: 291 AVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDA 350
Query: 310 CIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPE 368
+ E R + ++ +L T + Y +PKG + + + + +P P F P
Sbjct: 351 VVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPH 410
Query: 369 RWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPP 428
+L + + + K+ F+ PF G R C+G +A +E+ FLT IL+NF ++ P
Sbjct: 411 HFLDEGGN---FKKSKYFM--PFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPK 465
Query: 429 KIIQTSI 435
+ T +
Sbjct: 466 NLDTTPV 472
>AY514490-1|AAR89907.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 8 protein.
Length = 490
Score = 67.7 bits (158), Expect = 8e-11
Identities = 56/201 (27%), Positives = 88/201 (43%), Gaps = 24/201 (11%)
Query: 235 KNENKPDEQKGVLEKLLDINEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKL 294
K E + D QK + N E D+ VAG +T + ++ L L K+PE K+
Sbjct: 270 KMEQEKDNQKS------EFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKV 323
Query: 295 REEV------------MSKESKRYLKACIKETMRMMPVV-SGNLRRTTKEYNILGYHVPK 341
+EE+ + Y A + E R +V +G T + Y +PK
Sbjct: 324 QEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPK 383
Query: 342 GIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGR 401
G + + ++ +P P F P +L DKN + K+ F+ PF G R C G
Sbjct: 384 GTTIMALLTSVLHDDKEFPNPNIFDPGHFL-DKNGN--FKKSDYFM--PFSAGKRICAGE 438
Query: 402 RIAELEIETFLTKILENFRVE 422
+A +E+ FLT IL+NF ++
Sbjct: 439 GLARMELFLFLTTILQNFNLK 459
>AY341248-1|AAP88931.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 67.7 bits (158), Expect = 8e-11
Identities = 47/187 (25%), Positives = 84/187 (44%), Gaps = 18/187 (9%)
Query: 262 ATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSKESKRYLKA 309
A D+ AG +T + ++ L L K+PE K++EE+ + Y A
Sbjct: 291 AVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDA 350
Query: 310 CIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPE 368
+ E R + ++ +L T + Y +PKG + + + + +P P F P
Sbjct: 351 VVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPH 410
Query: 369 RWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPP 428
+L + + + K+ F+ PF G R C+G +A +E+ FLT IL+NF ++ P
Sbjct: 411 HFLDEGGN---FKKSKYFM--PFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPK 465
Query: 429 KIIQTSI 435
+ T +
Sbjct: 466 NLDTTPV 472
>AL359672-5|CAH71307.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 8 protein.
Length = 490
Score = 67.7 bits (158), Expect = 8e-11
Identities = 56/201 (27%), Positives = 88/201 (43%), Gaps = 24/201 (11%)
Query: 235 KNENKPDEQKGVLEKLLDINEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKL 294
K E + D QK + N E D+ VAG +T + ++ L L K+PE K+
Sbjct: 270 KMEQEKDNQKS------EFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKV 323
Query: 295 REEV------------MSKESKRYLKACIKETMRMMPVV-SGNLRRTTKEYNILGYHVPK 341
+EE+ + Y A + E R +V +G T + Y +PK
Sbjct: 324 QEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPK 383
Query: 342 GIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGR 401
G + + ++ +P P F P +L DKN + K+ F+ PF G R C G
Sbjct: 384 GTTIMALLTSVLHDDKEFPNPNIFDPGHFL-DKNGN--FKKSDYFM--PFSAGKRICAGE 438
Query: 402 RIAELEIETFLTKILENFRVE 422
+A +E+ FLT IL+NF ++
Sbjct: 439 GLARMELFLFLTTILQNFNLK 459
>AL359672-1|CAH71303.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 67.7 bits (158), Expect = 8e-11
Identities = 47/187 (25%), Positives = 84/187 (44%), Gaps = 18/187 (9%)
Query: 262 ATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------MSKESKRYLKA 309
A D+ AG +T + ++ L L K+PE K++EE+ + Y A
Sbjct: 291 AVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDA 350
Query: 310 CIKETMRMMPVVSGNL-RRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPE 368
+ E R + ++ +L T + Y +PKG + + + + +P P F P
Sbjct: 351 VVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPH 410
Query: 369 RWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENFRVEWYGPPP 428
+L + + + K+ F+ PF G R C+G +A +E+ FLT IL+NF ++ P
Sbjct: 411 HFLDEGGN---FKKSKYFM--PFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPK 465
Query: 429 KIIQTSI 435
+ T +
Sbjct: 466 NLDTTPV 472
>M21941-1|AAA52160.1| 480|Homo sapiens CYP2C protein.
Length = 480
Score = 66.9 bits (156), Expect = 1e-10
Identities = 56/201 (27%), Positives = 88/201 (43%), Gaps = 24/201 (11%)
Query: 235 KNENKPDEQKGVLEKLLDINEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKL 294
K E + D QK + N E D+ VAG +T + ++ L L K+PE K+
Sbjct: 260 KMEQEKDNQKS------EFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKV 313
Query: 295 REEV------------MSKESKRYLKACIKETMRMMPVV-SGNLRRTTKEYNILGYHVPK 341
+EE+ + Y A + E R +V +G T + Y +PK
Sbjct: 314 QEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPK 373
Query: 342 GIDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGR 401
G + + ++ +P P F P +L DKN + K+ F+ PF G R C G
Sbjct: 374 GTTIMALLTSVLHDDKEFPNPNIFDPGLFL-DKNGN--FKKSDYFM--PFSAGKRICAGE 428
Query: 402 RIAELEIETFLTKILENFRVE 422
+A +E+ FLT IL+NF ++
Sbjct: 429 GLARMELFLFLTTILQNFNLK 449
>BC022539-1|AAH22539.1| 500|Homo sapiens cytochrome P450, family
46, subfamily A, polypeptide 1 protein.
Length = 500
Score = 66.9 bits (156), Expect = 1e-10
Identities = 48/163 (29%), Positives = 78/163 (47%), Gaps = 19/163 (11%)
Query: 267 VAGVDTVANSIAATLYLFAKNPEKQEKLREEVMSK-ESKRYL-----------KACIKET 314
+AG +T AN +A T+ ++ PE +L+ EV SKRYL +KE+
Sbjct: 301 IAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKES 360
Query: 315 MRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADK 374
+R+ P G R +E I G VP + F+ + M+ ++ P F P+R+
Sbjct: 361 LRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGA 420
Query: 375 NDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILE 417
P F PF G RSCIG++ A++E++ + K+L+
Sbjct: 421 PKP-------RFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQ 456
>AF094480-1|AAD41244.1| 500|Homo sapiens cholesterol 24-hydroxylase
protein.
Length = 500
Score = 66.9 bits (156), Expect = 1e-10
Identities = 48/163 (29%), Positives = 78/163 (47%), Gaps = 19/163 (11%)
Query: 267 VAGVDTVANSIAATLYLFAKNPEKQEKLREEVMSK-ESKRYL-----------KACIKET 314
+AG +T AN +A T+ ++ PE +L+ EV SKRYL +KE+
Sbjct: 301 IAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKES 360
Query: 315 MRMMPVVSGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYPRPTEFIPERWLADK 374
+R+ P G R +E I G VP + F+ + M+ ++ P F P+R+
Sbjct: 361 LRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGA 420
Query: 375 NDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILE 417
P F PF G RSCIG++ A++E++ + K+L+
Sbjct: 421 PKP-------RFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQ 456
>X51535-1|CAA35915.1| 210|Homo sapiens cytochrome P-450 HPH (120
AA) protein.
Length = 210
Score = 66.1 bits (154), Expect = 2e-10
Identities = 51/184 (27%), Positives = 81/184 (44%), Gaps = 18/184 (9%)
Query: 252 DINEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV------------M 299
+ N E D+ VAG +T + ++ L L K+PE K++EE+
Sbjct: 1 EFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQ 60
Query: 300 SKESKRYLKACIKETMRMMPVV-SGNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEH 358
+ Y A + E R +V +G T + Y +PKG + + +
Sbjct: 61 DRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDRE 120
Query: 359 YPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILEN 418
+P P F P +L DKN + K+ F+ PF G R C G +A +E+ FLT IL+N
Sbjct: 121 FPNPNIFDPGHFL-DKNGN--FKKSDYFM--PFSAGKRICAGEGLARMELFLFLTTILQN 175
Query: 419 FRVE 422
F ++
Sbjct: 176 FNLK 179
>DQ282153-1|ABB77901.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 66.1 bits (154), Expect = 2e-10
Identities = 47/179 (26%), Positives = 87/179 (48%), Gaps = 18/179 (10%)
Query: 254 NEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEV--MSKESKR------ 305
N+E I+ D+ AG+ T + ++A L L +P+ Q ++++E+ M + +R
Sbjct: 291 NDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDMIGQVRRPEMGDQ 350
Query: 306 ----YLKACIKETMRMMPVVS-GNLRRTTKEYNILGYHVPKGIDVAFAHQDLSSMEEHYP 360
Y A I E R +V G T+++ + G+ +PKG + + E +
Sbjct: 351 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 410
Query: 361 RPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILENF 419
+P F PE +L + ++ K F+ PF G R+C+G +A +E+ F T +L++F
Sbjct: 411 KPFRFHPEHFLDAQG---HFVKPEAFL--PFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>BC067440-1|AAH67440.1| 520|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 2 protein.
Length = 520
Score = 66.1 bits (154), Expect = 2e-10
Identities = 54/184 (29%), Positives = 83/184 (45%), Gaps = 20/184 (10%)
Query: 253 INEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEVM----SKESKR--- 305
+++E A + G DT A+ ++ LY AK+PE QE+ R+EV +E K
Sbjct: 313 LSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEW 372
Query: 306 -------YLKACIKETMRMMPVVSGNLRRTTKEYNIL-GYHVPKGIDVAFAHQDLSSMEE 357
+L C+KE++R+ P V R T++ + G +PKGI +
Sbjct: 373 DDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPA 432
Query: 358 HYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILE 417
+P P + P R+ DP + P PF G R+CIG+ A E++ L L
Sbjct: 433 MWPDPEVYDPFRF-----DPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLL 487
Query: 418 NFRV 421
FRV
Sbjct: 488 RFRV 491
>AY792513-1|AAV40834.1| 520|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 3 protein.
Length = 520
Score = 66.1 bits (154), Expect = 2e-10
Identities = 55/184 (29%), Positives = 83/184 (45%), Gaps = 20/184 (10%)
Query: 253 INEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEVM----SKESKR--- 305
+++E A + G DT A+ ++ LY AK+PE QE+ R+EV +E K
Sbjct: 313 LSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEW 372
Query: 306 -------YLKACIKETMRMMPVVSGNLRRTTKEYNIL-GYHVPKGIDVAFAHQDLSSMEE 357
+L CIKE++R+ P V R T++ + G +PKGI +
Sbjct: 373 DDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPA 432
Query: 358 HYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILE 417
+P P + P R+ DP + P PF G R+CIG+ A E++ L L
Sbjct: 433 VWPDPEVYDPFRF-----DPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLL 487
Query: 418 NFRV 421
FRV
Sbjct: 488 RFRV 491
>AF054821-1|AAC08589.1| 520|Homo sapiens cytochrome P-450 protein.
Length = 520
Score = 66.1 bits (154), Expect = 2e-10
Identities = 55/184 (29%), Positives = 83/184 (45%), Gaps = 20/184 (10%)
Query: 253 INEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEVM----SKESKR--- 305
+++E A + G DT A+ ++ LY AK+PE QE+ R+EV +E K
Sbjct: 313 LSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEW 372
Query: 306 -------YLKACIKETMRMMPVVSGNLRRTTKEYNIL-GYHVPKGIDVAFAHQDLSSMEE 357
+L CIKE++R+ P V R T++ + G +PKGI +
Sbjct: 373 DDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPA 432
Query: 358 HYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILE 417
+P P + P R+ DP + P PF G R+CIG+ A E++ L L
Sbjct: 433 VWPDPEVYDPFRF-----DPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLL 487
Query: 418 NFRV 421
FRV
Sbjct: 488 RFRV 491
>AB015306-1|BAA75823.1| 520|Homo sapiens Leukotriene B4
omega-hydroxylase protein.
Length = 520
Score = 66.1 bits (154), Expect = 2e-10
Identities = 54/184 (29%), Positives = 83/184 (45%), Gaps = 20/184 (10%)
Query: 253 INEEYAYIMATDMLVAGVDTVANSIAATLYLFAKNPEKQEKLREEVM----SKESKR--- 305
+++E A + G DT A+ ++ LY AK+PE QE+ R+EV +E K
Sbjct: 313 LSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEW 372
Query: 306 -------YLKACIKETMRMMPVVSGNLRRTTKEYNIL-GYHVPKGIDVAFAHQDLSSMEE 357
+L C+KE++R+ P V R T++ + G +PKGI +
Sbjct: 373 DDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPA 432
Query: 358 HYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCIGRRIAELEIETFLTKILE 417
+P P + P R+ DP + P PF G R+CIG+ A E++ L L
Sbjct: 433 MWPDPEVYDPFRF-----DPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLL 487
Query: 418 NFRV 421
FRV
Sbjct: 488 RFRV 491
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.320 0.136 0.403
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 65,573,791
Number of Sequences: 224733
Number of extensions: 2628478
Number of successful extensions: 6985
Number of sequences better than 10.0: 448
Number of HSP's better than 10.0 without gapping: 394
Number of HSP's successfully gapped in prelim test: 54
Number of HSP's that attempted gapping in prelim test: 5859
Number of HSP's gapped (non-prelim): 546
length of query: 452
length of database: 73,234,838
effective HSP length: 92
effective length of query: 360
effective length of database: 52,559,402
effective search space: 18921384720
effective search space used: 18921384720
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.8 bits)
S2: 67 (31.1 bits)
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