Silkworm BLAST Result against human

BLASTP 2.2.12 [Aug-07-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= BGIBMGA001276-TA|BGIBMGA001276-PA|IPR001128|Cytochrome P450,
IPR002401|E-class P450, group I
         (458 letters)

Database: human 
           224,733 sequences; 73,234,838 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

AY178622-1|AAO21126.1|  531|Homo sapiens steroid hydroxylase pro...   161   5e-39
M62401-1|AAA52142.1|  531|Homo sapiens sterol 27-hydroxylase pro...   160   8e-39
BC051851-1|AAH51851.1|  531|Homo sapiens cytochrome P450, family...   160   8e-39
BC040430-1|AAH40430.1|  531|Homo sapiens cytochrome P450, family...   160   8e-39
X59812-1|CAA42481.1|  530|Homo sapiens Vitamin D3 25-hydroxylase...   159   1e-38
AY288916-1|AAP31972.1|  508|Homo sapiens cytochrome P450, family...   157   1e-37
AF256213-1|AAG00416.1|  508|Homo sapiens 25- hydroxyvitamin D-1-...   157   1e-37
AF246895-1|AAF64299.1|  508|Homo sapiens 25-hydroxyvitamin D-1-a...   157   1e-37
AF027152-1|AAC51854.1|  508|Homo sapiens P450 25-hydroxyvitamin ...   157   1e-37
AF020192-1|AAC51853.1|  508|Homo sapiens 25-hydroxyvitamin D-1-a...   157   1e-37
AB006987-1|BAA23418.1|  508|Homo sapiens 25-hydroxyvitamin D3 1-...   157   1e-37
AB005990-1|BAA22657.1|  508|Homo sapiens 25-hydroxyvitamin D3 1a...   157   1e-37
AB005989-1|BAA22656.1|  508|Homo sapiens 25-hydroxyvitamin D3 1a...   157   1e-37
AB005038-1|BAA23416.1|  508|Homo sapiens 25-hydroxyvitamin D3 1-...   157   1e-37
AK131190-1|BAD18388.1|  372|Homo sapiens .-.-).  protein.             153   2e-36
BC039307-1|AAH39307.1|  372|Homo sapiens FLJ16008 protein protein.    152   3e-36
X05367-1|CAA28965.1|  521|Homo sapiens desmolase protein.             141   4e-33
BC032329-1|AAH32329.1|  521|Homo sapiens cytochrome P450, family...   141   4e-33
M14565-1|AAA52162.1|  521|Homo sapiens CYP11A protein.                140   7e-33
AL138805-3|CAB91829.1|  514|Homo sapiens cytochrome P450, family...   135   3e-31
L13286-1|AAA62379.1|  513|Homo sapiens 1,25-dihydroxyvitamin D3 ...   133   1e-30
AY858838-1|AAW50795.1|  372|Homo sapiens vitamin D 24-hydroxylas...   130   1e-29
AL138805-1|CAM27342.1|  372|Homo sapiens cytochrome P450, family...   130   1e-29
D13752-1|BAA02899.1|  503|Homo sapiens steroid 18-hydroxylase pr...   112   3e-24
X54741-1|CAA38539.1|  503|Homo sapiens aldosterone  synthase (P-...   110   1e-23
M32881-1|AAA35741.1|  503|Homo sapiens protein ( Human steroid 1...   109   2e-23
X55764-1|CAA39290.1|  503|Homo sapiens protein ( Human mRNA for ...   109   3e-23
M32879-1|AAA52149.1|  503|Homo sapiens CYP11B1 protein.               109   3e-23
BC096287-1|AAH96287.1|  503|Homo sapiens cytochrome P450, family...   109   3e-23
AF478474-1|AAL84813.1|  503|Homo sapiens mutated cytochrome P-45...   107   6e-23
BC096285-1|AAH96285.1|  574|Homo sapiens CYP11B1 protein protein.     106   1e-22
S67623-1|AAB29308.1|  257|Homo sapiens 25-hydroxyvitamin D 24-hy...    98   5e-20
M28253-1|AAA36404.1|  239|Homo sapiens cytochrome P-450-scc prot...    95   3e-19
M18907-1|AAA35745.1|  503|Homo sapiens protein ( Human P450 mRNA...    87   1e-16
DQ924960-1|ABI96208.1|  503|Homo sapiens cytochrome P450 family ...    87   1e-16
DQ005611-1|AAY16980.1|  503|Homo sapiens cytochrome P450, family...    87   1e-16
BC101631-1|AAI01632.1|  503|Homo sapiens cytochrome P450, subfam...    87   1e-16
BC069418-1|AAH69418.1|  503|Homo sapiens cytochrome P450, family...    87   1e-16
AJ563377-1|CAD91345.1|  353|Homo sapiens cytochrome P450 protein.      87   1e-16
AJ563376-2|CAD91645.1|  430|Homo sapiens cytochrome P450 protein.      87   1e-16
AJ563375-1|CAD91343.1|  503|Homo sapiens cytochrome P450 protein.      87   1e-16
AF280107-2|AAG32290.1|  503|Homo sapiens cytochrome P450 polypep...    87   1e-16
AF209389-1|AAF21034.1|  503|Homo sapiens cytochrome P450 IIIA4 p...    87   1e-16
AF182273-1|AAF13598.1|  503|Homo sapiens cytochrome P450-3A4 pro...    87   1e-16
BC109084-1|AAI09085.1|  448|Homo sapiens CYP24A1 protein protein.      86   3e-16
BC109083-1|AAI09084.1|  448|Homo sapiens CYP24A1 protein protein.      86   3e-16
AL138805-2|CAM27343.1|  448|Homo sapiens cytochrome P450, family...    86   3e-16
BC060857-1|AAH60857.1|  525|Homo sapiens cytochrome P450, family...    85   5e-16
AY422002-1|AAR31180.1|  525|Homo sapiens cytochrome P450 4V2 pro...    85   5e-16
AK126473-1|BAC86562.1|  503|Homo sapiens protein ( Homo sapiens ...    85   5e-16
AK122600-1|BAC85487.1|  525|Homo sapiens protein ( Homo sapiens ...    85   5e-16
M14096-1|AAA35744.1|  503|Homo sapiens protein ( Human cytochrom...    85   7e-16
J04449-1|AAA35747.1|  502|Homo sapiens cytochrome P450 nifedipin...    85   7e-16
X12387-1|CAA30944.1|  503|Homo sapiens protein ( Human mRNA for ...    84   9e-16
M13785-1|AAA35742.1|  504|Homo sapiens protein ( Human liver glu...    84   1e-15
D00003-1|BAA00001.1|  504|Homo sapiens cytochrome P-450 protein.       84   1e-15
J04813-1|AAA02993.1|  502|Homo sapiens cytochrome P450 PCN3 prot...    82   3e-15
BC033862-1|AAH33862.1|  502|Homo sapiens cytochrome P450, family...    82   3e-15
AK223008-1|BAD96728.1|  502|Homo sapiens cytochrome P450, family...    82   3e-15
AC005020-1|AAS02016.1|  502|Homo sapiens unknown protein.              82   3e-15
D00408-1|BAA00310.1|  503|Homo sapiens cytochrome P-450 HFLa pro...    82   5e-15
BC067436-1|AAH67436.1|  503|Homo sapiens cytochrome P450, family...    82   5e-15
AF315325-1|AAG48618.1|  535|Homo sapiens cytochrome P450 variant...    82   5e-15
AF280107-3|AAG32289.1|  503|Homo sapiens cytochrome P450 polypep...    82   5e-15
AK054616-1|BAB70774.1|  465|Homo sapiens protein ( Homo sapiens ...    78   7e-14
BC028102-1|AAH28102.1|  509|Homo sapiens cytochrome P450, family...    77   1e-13
AY358537-1|AAQ88901.1|  509|Homo sapiens EFSW1929 protein.             77   1e-13
AM040940-1|CAJ13826.1|  509|Homo sapiens cytochrome P450 protein.      77   1e-13
AL450996-1|CAH71035.1|  509|Homo sapiens cytochrome P450, family...    77   1e-13
AK131355-1|BAD18508.1|  508|Homo sapiens protein ( Homo sapiens ...    77   1e-13
AK098065-1|BAC05226.1|  509|Homo sapiens protein ( Homo sapiens ...    77   1e-13
AK091806-1|BAC03751.1|  444|Homo sapiens protein ( Homo sapiens ...    77   1e-13
M28548-1|AAA52065.1|  495|Homo sapiens protein ( Human mutant 21...    77   1e-13
X58906-1|CAA41709.1|  495|Homo sapiens steroid 21-monooxygenase ...    77   2e-13
M24667-1|AAA52148.1|  256|Homo sapiens steroid 11-beta-hydroxyla...    77   2e-13
M26856-1|AAA52064.1|  495|Homo sapiens protein ( Human 21-hydrox...    76   2e-13
M13936-1|AAA59695.1|  494|Homo sapiens CYP21P protein.                 76   2e-13
BX679671-8|CAM26071.1|  464|Homo sapiens cytochrome P450, family...    76   2e-13
BX679671-7|CAM26070.1|  494|Homo sapiens cytochrome P450, family...    76   2e-13
BC125182-1|AAI25183.1|  494|Homo sapiens cytochrome P450, family...    76   2e-13
BC125181-1|AAI25182.1|  495|Homo sapiens cytochrome P450, family...    76   2e-13
AY390424-1|AAQ92352.1|  503|Homo sapiens cytochrome P450 CYP3A43...    76   2e-13
AM183951-1|CAJ75805.1|  494|Homo sapiens steroid 21-hydroxylase,...    76   2e-13
AM183945-1|CAJ75799.1|  494|Homo sapiens steroid 21-hydroxylase,...    76   2e-13
AM086565-1|CAJ31104.1|  494|Homo sapiens steroid 21-hydroxylase,...    76   2e-13
AL929593-2|CAI41778.1|  465|Homo sapiens cytochrome P450, family...    76   2e-13
AL929593-1|CAI41779.1|  495|Homo sapiens cytochrome P450, family...    76   2e-13
AL662849-19|CAI17480.1|  465|Homo sapiens cytochrome P450, famil...    76   2e-13
AL662849-18|CAI17479.1|  495|Homo sapiens cytochrome P450, famil...    76   2e-13
AL645922-24|CAI41754.1|  495|Homo sapiens cytochrome P450, famil...    76   2e-13
AL645922-23|CAI41755.1|  465|Homo sapiens cytochrome P450, famil...    76   2e-13
AL049547-7|CAB89301.1|  495|Homo sapiens dJ34F7.3 (cytochrome P4...    76   2e-13
AF077974-1|AAD45405.1|  403|Homo sapiens cytochrome P450 21-hydr...    76   2e-13
AF019413-2|AAB67982.1|  495|Homo sapiens cytochrome P450 21-hydr...    76   2e-13
M21550-1|AAA52063.1|  495|Homo sapiens CYP21 protein.                  76   3e-13
AM183949-1|CAJ75803.1|  494|Homo sapiens steroid 21-hydroxylase,...    76   3e-13
AM183946-1|CAJ75800.1|  494|Homo sapiens steroid 21-hydroxylase,...    76   3e-13
BC100981-1|AAI00982.1|  393|Homo sapiens CYP3A43 protein protein.      75   4e-13
AY390425-1|AAQ92353.1|  503|Homo sapiens cytochrome P450 CYP3A43...    75   4e-13
AF337813-1|AAK38841.1|  503|Homo sapiens cytochrome P450 subfami...    75   4e-13
AF319634-1|AAK00325.1|  503|Homo sapiens cytochrome P450 CYP3A43...    75   4e-13
AF280108-1|AAG33009.1|  503|Homo sapiens cytochrome P450 subfami...    75   4e-13
AC011904-4|AAS07395.1|  503|Homo sapiens unknown protein.              75   4e-13
AM183947-1|CAJ75801.1|  494|Homo sapiens steroid 21-hydroxylase,...    75   5e-13
AM086564-1|CAJ31103.1|  494|Homo sapiens steroid 21-hydroxylase,...    75   5e-13
AF233624-1|AAF99278.1|  534|Homo sapiens thromboxane synthase pr...    75   5e-13
M80647-1|AAA60618.1|  534|Homo sapiens thromboxane synthase prot...    75   7e-13
BC041157-1|AAH41157.1|  534|Homo sapiens thromboxane A synthase ...    75   7e-13
BC014117-1|AAH14117.1|  466|Homo sapiens TBXAS1 protein protein.       75   7e-13
AK223466-1|BAD97186.1|  534|Homo sapiens thromboxane A synthase ...    75   7e-13
AF233625-1|AAF99279.1|  534|Homo sapiens thromboxane synthase pr...    75   7e-13
AF233623-1|AAF99277.1|  534|Homo sapiens thromboxane synthase pr...    75   7e-13
AF233622-1|AAF99276.1|  534|Homo sapiens thromboxane synthase pr...    75   7e-13
AF233620-1|AAF99274.1|  534|Homo sapiens thromboxane synthase pr...    75   7e-13
AF233619-1|AAF99273.1|  534|Homo sapiens thromboxane synthase pr...    75   7e-13
AF233618-1|AAF99272.1|  534|Homo sapiens thromboxane synthase pr...    75   7e-13
AF233617-1|AAF99271.1|  534|Homo sapiens thromboxane synthase pr...    75   7e-13
AF233616-1|AAF99270.1|  534|Homo sapiens thromboxane synthase pr...    75   7e-13
AF233615-1|AAF99269.1|  534|Homo sapiens thromboxane synthase pr...    75   7e-13
BC132767-1|AAI32768.1|  544|Homo sapiens cytochrome P450, family...    74   9e-13
AY343323-1|AAQ21380.1|  544|Homo sapiens cytochrome P450 protein.      74   9e-13
AM183948-1|CAJ75802.1|  494|Homo sapiens steroid 21-hydroxylase ...    74   9e-13
M17252-1|AAA59985.1|  230|Homo sapiens CYP21 protein.                  73   2e-12
AM183950-1|CAJ75804.1|  494|Homo sapiens steroid 21-hydroxylase,...    73   2e-12
AF233621-1|AAF99275.1|  534|Homo sapiens thromboxane synthase pr...    73   2e-12
BC104909-1|AAI04910.1|  501|Homo sapiens cytochrome P450, family...    73   2e-12
BC104907-1|AAI04908.1|  501|Homo sapiens cytochrome P450, family...    73   2e-12
AY323817-1|AAQ23114.1|  501|Homo sapiens cytochrome P450 2R1 pro...    73   2e-12
D34625-1|BAA07011.1|  533|Homo sapiens thromboxane synthase prot...    73   3e-12
AF280109-1|AAG33010.1|  504|Homo sapiens cytochrome P450 subfami...    73   3e-12
AC011904-5|AAS07394.1|  504|Homo sapiens unknown protein.              73   3e-12
M12792-1|AAB59440.1|  494|Homo sapiens steroid 21-hydroxylase pr...    72   4e-12
AY358631-1|AAQ88994.1|  505|Homo sapiens EPSW3060 protein.             72   4e-12
AY262056-1|AAO89257.1|  505|Homo sapiens cytochrome P450 protein.      72   4e-12
AL450996-2|CAH71036.1|  505|Homo sapiens cytochrome P450, family...    72   4e-12
AL135960-6|CAI19734.1|  505|Homo sapiens cytochrome P450, family...    72   4e-12
DQ211353-1|ABB01370.1|  497|Homo sapiens cytochrome P450 2D6 pro...    71   1e-11
BC035959-1|AAH35959.1|  503|Homo sapiens cytochrome P450, family...    69   3e-11
Y07508-1|CAA68807.1|  503|Homo sapiens protein ( Human mRNA for ...    69   3e-11
X13589-1|CAA31929.1|  503|Homo sapiens protein ( Human mRNA for ...    69   3e-11
M30804-1|AAA35728.1|  503|Homo sapiens protein ( Human aromatase...    69   3e-11
M22246-1|AAA35557.1|  503|Homo sapiens protein ( Human aromatase...    69   3e-11
M18856-1|AAA35556.1|  419|Homo sapiens protein ( Human aromatase...    69   3e-11
DQ118405-1|AAZ23558.1|  503|Homo sapiens cytochrome P450 subfami...    69   3e-11
AY957953-1|AAX44046.1|  503|Homo sapiens cytochrome P450, family...    69   3e-11
X08006-1|CAA30807.1|  497|Homo sapiens cytochrome P450 db1 protein.    69   5e-11
M28420-1|AAA52141.1|  419|Homo sapiens cytochrome P-450 aromatas...    69   5e-11
M20403-1|AAA52153.1|  497|Homo sapiens CYP2D protein.                  69   5e-11
J04127-1|AAA52132.1|  503|Homo sapiens CYP19 protein.                  69   5e-11
M33388-1|AAA53500.1|  497|Homo sapiens cytochrome P450 IID6 prot...    68   6e-11
M33189-1|AAA35737.1|  500|Homo sapiens protein ( Human debrisoqu...    68   6e-11
M24499-1|AAA36403.1|  373|Homo sapiens cytochrome P450db1 protein.     68   6e-11
DQ282162-1|ABB77909.1|  500|Homo sapiens cytochrome P450 2D6 pro...    68   6e-11
DQ282160-1|ABB77908.1|  497|Homo sapiens cytochrome P450 2D6 pro...    68   6e-11
DQ282159-1|ABB77907.1|  497|Homo sapiens cytochrome P450 2D6 pro...    68   6e-11
DQ282158-1|ABB77906.1|  497|Homo sapiens cytochrome P450 2D6 pro...    68   6e-11
DQ282157-1|ABB77905.1|  497|Homo sapiens cytochrome P450 2D6 pro...    68   6e-11
DQ282156-1|ABB77904.1|  497|Homo sapiens cytochrome P450 2D6 pro...    68   6e-11
DQ282155-1|ABB77903.1|  497|Homo sapiens cytochrome P450 2D6 pro...    68   6e-11
DQ282154-1|ABB77902.1|  497|Homo sapiens cytochrome P450 2D6 pro...    68   6e-11
DQ282153-1|ABB77901.1|  497|Homo sapiens cytochrome P450 2D6 pro...    68   6e-11
DQ282152-1|ABB77900.1|  497|Homo sapiens cytochrome P450 2D6 pro...    68   6e-11
DQ282151-1|ABB77899.1|  496|Homo sapiens cytochrome P450 2D6 pro...    68   6e-11
DQ282147-1|ABB77898.1|  497|Homo sapiens cytochrome P450 2D6 pro...    68   6e-11
DQ282146-1|ABB77897.1|  497|Homo sapiens cytochrome P450 2D6 pro...    68   6e-11
DQ282145-1|ABB77896.1|  497|Homo sapiens cytochrome P450 2D6 pro...    68   6e-11
DQ282144-1|ABB77895.1|  497|Homo sapiens cytochrome P450 2D6 pro...    68   6e-11
DQ211354-2|ABB01372.1|  497|Homo sapiens cytochrome P450 2D6 pro...    68   6e-11
DQ211353-2|ABB01371.1|  497|Homo sapiens cytochrome P450 2D6 pro...    68   6e-11
CR456430-1|CAG30316.1|  446|Homo sapiens CYP2D6 protein.               68   6e-11
BC126858-1|AAI26859.1|  497|Homo sapiens cytochrome P450, family...    68   6e-11
BC107785-1|AAI07786.1|  503|Homo sapiens cytochrome P450, family...    68   6e-11
BC106758-1|AAI06759.1|  497|Homo sapiens cytochrome P450, family...    68   6e-11
BC106757-1|AAI06758.1|  446|Homo sapiens cytochrome P450, family...    68   6e-11
BC075024-1|AAH75024.1|  497|Homo sapiens cytochrome P450, family...    68   6e-11
BC075023-1|AAH75023.1|  497|Homo sapiens cytochrome P450, family...    68   6e-11
BC067432-1|AAH67432.1|  497|Homo sapiens cytochrome P450, family...    68   6e-11
BC066877-1|AAH66877.1|  446|Homo sapiens CYP2D6 protein protein.       68   6e-11
AY545216-1|AAS55001.1|  497|Homo sapiens cytochrome P4502D6 prot...    68   6e-11
AB209492-1|BAD92729.1|  566|Homo sapiens Debrisoquine 4-hydroxyl...    68   6e-11
M63871-1|AAA59984.1|  508|Homo sapiens CYP17 protein.                  68   8e-11
M31153-1|AAA52140.1|  508|Homo sapiens CYP17 protein.                  68   8e-11
M19489-1|AAA36405.1|  508|Homo sapiens CYP17 protein.                  68   8e-11
M14564-1|AAA52151.1|  508|Homo sapiens CYP17 protein.                  68   8e-11
DQ530598-1|ABF50972.1|  508|Homo sapiens cytochrome P450, family...    68   8e-11
BT020000-1|AAV38803.1|  508|Homo sapiens cytochrome P450, family...    68   8e-11
BC063388-1|AAH63388.1|  508|Homo sapiens cytochrome P450, family...    68   8e-11
BC062997-1|AAH62997.1|  508|Homo sapiens cytochrome P450, family...    68   8e-11
BC022539-1|AAH22539.1|  500|Homo sapiens cytochrome P450, family...    68   8e-11
AL358790-3|CAI52498.1|  508|Homo sapiens cytochrome P450, family...    68   8e-11
AF094480-1|AAD41244.1|  500|Homo sapiens cholesterol 24-hydroxyl...    68   8e-11
AL358613-1|CAH72802.2|  522|Homo sapiens cytochrome P450, family...    65   4e-10
X16699-1|CAA34672.1|  511|Homo sapiens protein ( Human mRNA for ...    65   6e-10
J02871-1|AAA35712.1|  511|Homo sapiens protein ( Human lung cyto...    65   6e-10
DQ518907-1|ABF47106.1|  511|Homo sapiens cytochrome P450, family...    65   6e-10
BC017758-1|AAH17758.1|  512|Homo sapiens cytochrome P450, family...    65   6e-10
AY151049-1|AAN72312.1|  497|Homo sapiens pulmonary cytochrome P4...    65   6e-10
AY151048-1|AAN72311.1|  512|Homo sapiens pulmonary cytochrome P4...    65   6e-10
AY064485-1|AAL57720.1|  511|Homo sapiens cytochrome P450 protein.      65   6e-10
AL593856-7|CAI16983.1|  497|Homo sapiens cytochrome P450, family...    65   6e-10
AL593856-6|CAI16982.1|  512|Homo sapiens cytochrome P450, family...    65   6e-10
AL593856-5|CAI16981.1|  511|Homo sapiens cytochrome P450, family...    65   6e-10
AL356793-4|CAI22559.1|  511|Homo sapiens cytochrome P450, family...    65   6e-10
AL356793-3|CAI22557.1|  512|Homo sapiens cytochrome P450, family...    65   6e-10
AL356793-2|CAI22558.1|  497|Homo sapiens cytochrome P450, family...    65   6e-10
X02612-1|CAA26458.1|  512|Homo sapiens cytochrome P(1)-450 protein.    64   7e-10
AY064486-1|AAL57721.1|  511|Homo sapiens cytochrome P450 protein.      64   7e-10
X04300-1|CAA27843.1|  512|Homo sapiens P-450 c protein.                64   1e-09
M61854-1|AAB59426.1|  490|Homo sapiens cytochrome protein.             64   1e-09
L07093-1|AAA36660.1|  468|Homo sapiens cytochrome P450 protein.        64   1e-09
EF094025-1|ABK41999.1|  512|Homo sapiens cytochrome P450, family...    64   1e-09
BC023019-1|AAH23019.1|  512|Homo sapiens cytochrome P450, family...    64   1e-09
AY796203-1|AAV41877.1|  490|Homo sapiens cytochrome P450, family...    64   1e-09
AY310359-1|AAQ76692.1|  484|Homo sapiens cytochrome P450 1A1 var...    64   1e-09
AM236047-1|CAJ84704.1|  251|Homo sapiens cytochrome P450 1A1 pro...    64   1e-09
AL583836-2|CAH74068.1|  490|Homo sapiens cytochrome P450, family...    64   1e-09
AL358613-3|CAH72804.1|  428|Homo sapiens cytochrome P450, family...    64   1e-09
AL358613-2|CAH72803.1|  497|Homo sapiens cytochrome P450, family...    64   1e-09
AL133513-2|CAH73444.1|  490|Homo sapiens cytochrome P450, family...    64   1e-09
AK223113-1|BAD96833.1|  512|Homo sapiens cytochrome P450, family...    64   1e-09
AJ563378-3|CAD91347.1|  173|Homo sapiens hypothetical protein pr...    64   1e-09
AJ563378-2|CAD91647.1|  160|Homo sapiens cytochrome P450 protein.      64   1e-09
AF253322-1|AAK25727.1|  512|Homo sapiens cytochrome P450 protein.      64   1e-09
AF005418-1|AAB88881.1|  497|Homo sapiens retinoic acid hydroxyla...    64   1e-09
K03191-1|AAA52139.1|  512|Homo sapiens CYP1A1 protein.                 64   1e-09
AF491285-1|AAM09532.1|  511|Homo sapiens cytochrome P450 protein.      63   2e-09
AY356349-1|AAQ55485.1|  522|Homo sapiens cytochrome P450 protein.      63   2e-09
AK223108-1|BAD96828.1|  512|Homo sapiens cytochrome P450, family...    63   2e-09
X65962-1|CAA46778.1|  356|Homo sapiens cytochrome P-450 II C pro...    62   3e-09
L39102-1|AAL31348.1|  217|Homo sapiens S-mephenytoin 4-hydroxyla...    62   3e-09
BC096286-1|AAH96286.1|  437|Homo sapiens cytochrome P450, family...    62   4e-09
M12079-1|AAA52152.1|  191|Homo sapiens POR protein.                    61   7e-09
S67581-1|AAB29503.1|  591|Homo sapiens fatty acid omega-hydroxyl...    61   9e-09
S67580-1|AAB29502.1|  519|Homo sapiens fatty acid omega-hydroxyl...    61   9e-09
BC067429-1|AAH67429.1|  516|Homo sapiens cytochrome P450, family...    60   1e-08
BC067433-1|AAH67433.1|  493|Homo sapiens cytochrome P450, family...    60   2e-08
AF525488-1|AAO16078.1|  519|Homo sapiens cytochrome P450, subfam...    60   2e-08
U37143-1|AAC50370.2|  502|Homo sapiens cytochrome P450 monooxyge...    60   2e-08
L04751-1|AAA58436.1|  519|Homo sapiens cytochrome P450 protein.        60   2e-08
D26481-1|BAA05491.1|  519|Homo sapiens fatty acids omega-hydroxy...    60   2e-08
BC117165-1|AAI17166.1|  494|Homo sapiens cytochrome P450, family...    60   2e-08
BC032594-1|AAH32594.1|  502|Homo sapiens cytochrome P450, family...    60   2e-08
BC032322-1|AAH32322.1|  509|Homo sapiens cytochrome P450, family...    60   2e-08
AY426985-1|AAQ93356.1|  502|Homo sapiens cytochrome P450, family...    60   2e-08
AY369778-1|AAQ56847.1|  519|Homo sapiens cytochrome P450, family...    60   2e-08
AL731892-3|CAH72778.1|  519|Homo sapiens cytochrome P450, family...    60   2e-08
AF272142-1|AAM44456.1|  502|Homo sapiens cytochrome P450 protein.      60   2e-08
X13930-1|CAA32118.1|  494|Homo sapiens protein ( Human CYP2A4 mR...    59   3e-08
X13929-1|CAA32117.1|  448|Homo sapiens P-450 IIA3 protein (1 is ...    59   3e-08
U23942-1|AAB39951.1|  509|Homo sapiens lanosterol 14-demethylase...    59   3e-08
M33318-1|AAA52067.1|  494|Homo sapiens CYP2A protein.                  59   3e-08
M33317-1|AAA52138.1|  494|Homo sapiens CYP2A protein.                  59   3e-08
D55653-1|BAA09512.1|  509|Homo sapiens lanosterol 14-demethylase...    59   3e-08
BC096256-1|AAH96256.1|  494|Homo sapiens cytochrome P450, family...    59   3e-08
BC096255-1|AAH96255.1|  494|Homo sapiens cytochrome P450, family...    59   3e-08
BC096254-1|AAH96254.1|  494|Homo sapiens cytochrome P450, family...    59   3e-08
BC096253-1|AAH96253.3|  494|Homo sapiens cytochrome P450, family...    59   3e-08
AF182275-1|AAF13600.1|  494|Homo sapiens cytochrome P450-2A6 pro...    59   3e-08
AC000120-2|AAB46356.1|  509|Homo sapiens unknown protein.              59   3e-08
AB080265-1|BAB85489.1|  502|Homo sapiens cytochrome P450 2J2 pro...    59   3e-08
J02843-1|AAA52155.1|  493|Homo sapiens protein ( Human cytochrom...    59   4e-08
J02625-1|AAA35743.1|  493|Homo sapiens protein ( Human cytochrom...    59   4e-08
DQ515958-1|ABF47105.1|  493|Homo sapiens cytochrome P450, family...    59   4e-08
DQ149222-1|AAZ77710.1|  493|Homo sapiens cytochrome P450 2E1 pro...    59   4e-08
AL161645-2|CAH70047.1|  493|Homo sapiens cytochrome P450, family...    59   4e-08
AF182276-1|AAF13601.1|  493|Homo sapiens cytochrome P450-2E1 pro...    59   4e-08
AF084225-1|AAD13753.1|  462|Homo sapiens cytochrome P450 2E1 pro...    59   4e-08
L16876-1|AAA02630.1|  490|Homo sapiens cytochrome P-4502C18 prot...    58   6e-08
X13897-1|CAA32097.1|  489|Homo sapiens protein ( Human mRNA for ...    58   9e-08
M61856-1|AAB59356.1|  490|Homo sapiens cytochrome protein.             58   9e-08
BC096258-1|AAH96258.1|  490|Homo sapiens cytochrome P450, family...    58   9e-08
BC096257-1|AAH96257.1|  490|Homo sapiens cytochrome P450, family...    58   9e-08
BC069666-1|AAH69666.1|  490|Homo sapiens cytochrome P450, family...    58   9e-08
BC067435-1|AAH67435.1|  493|Homo sapiens cytochrome P450, family...    58   9e-08
BC016853-1|AAH16853.1|  524|Homo sapiens CYP4F11 protein protein.      58   9e-08
AL583836-1|CAH74067.1|  490|Homo sapiens cytochrome P450, family...    58   9e-08
AK223510-1|BAD97230.1|  490|Homo sapiens cytochrome P450, family...    58   9e-08
Z00036-1|CAA77335.1|  515|Homo sapiens protein ( Human mRNA for ...    57   1e-07
U22027-1|AAB40518.1|  494|Homo sapiens cytochrome P450 protein.        57   1e-07
M55053-1|AAA52146.1|  515|Homo sapiens cytochrome P3-450 protein.      57   1e-07
M31667-1|AAA52163.1|  515|Homo sapiens CYP1A2 protein.                 57   1e-07
L00389-1|AAA35738.1|  516|Homo sapiens protein ( Human cytochrom...    57   1e-07
D13705-1|BAA02864.1|  521|Homo sapiens fatty acid omega-hydroxyl...    57   1e-07
DQ022432-1|AAY26399.1|  516|Homo sapiens cytochrome P450, family...    57   1e-07
BC067428-1|AAH67428.1|  516|Homo sapiens cytochrome P450, family...    57   1e-07
BC067427-1|AAH67427.1|  516|Homo sapiens cytochrome P450, family...    57   1e-07
BC067426-1|AAH67426.1|  516|Homo sapiens cytochrome P450, family...    57   1e-07
BC067425-1|AAH67425.1|  516|Homo sapiens cytochrome P450, family...    57   1e-07
BC067424-1|AAH67424.1|  516|Homo sapiens cytochrome P450, family...    57   1e-07
AF253322-2|AAK25728.1|  516|Homo sapiens cytochrome P450 protein.      57   1e-07
U51692-1|AAC50951.1|  503|Homo sapiens lanosterol 14-alpha demet...    57   1e-07
BC100982-1|AAI00983.1|  280|Homo sapiens CYP3A43 protein protein.      57   1e-07
AF280110-1|AAG33011.1|  420|Homo sapiens cytochrome P450 subfami...    57   1e-07
S46963-1|AAB23864.2|  477|Homo sapiens cytochrome P-450 protein.       56   2e-07
M61858-1|AAA52145.1|  370|Homo sapiens CYP2C17 protein.                56   2e-07
M21940-1|AAA52159.1|  383|Homo sapiens CYP2C protein.                  56   2e-07
M21939-1|AAA52158.1|  485|Homo sapiens CYP2C protein.                  56   2e-07
M15331-1|AAA52157.1|  485|Homo sapiens CYP2C protein.                  56   2e-07
D00173-1|BAA00123.1|  487|Homo sapiens cytochrome P-450 protein.       56   2e-07
BC125054-1|AAI25055.1|  490|Homo sapiens cytochrome P450, family...    56   2e-07
AY702706-1|AAT94065.1|  490|Homo sapiens cytochrome P450, family...    56   2e-07
AY341248-1|AAP88931.1|  490|Homo sapiens cytochrome P450, family...    56   2e-07
AY280371-1|AAQ21367.1|  519|Homo sapiens cytochrome P450 4A22K p...    56   2e-07
AL359672-1|CAH71303.1|  490|Homo sapiens cytochrome P450, family...    56   2e-07
AF236085-1|AAG15889.1|  524|Homo sapiens CYP4F11 protein.              56   2e-07
AF133298-1|AAD49566.1|  520|Homo sapiens cytochrome P450 protein.      56   2e-07
Y00498-1|CAA68550.1|  490|Homo sapiens IIC2 protein.                   56   3e-07
M21942-1|AAA52161.1|  462|Homo sapiens CYP2C protein.                  56   3e-07
M17397-1|AAA35739.1|  490|Homo sapiens protein ( Human cytochrom...    56   3e-07
BX538127-1|CAD98029.1|  310|Homo sapiens hypothetical protein pr...    56   3e-07
BC096260-1|AAH96260.1|  431|Homo sapiens CYP2C18 protein protein.      56   3e-07
BC020596-1|AAH20596.1|  490|Homo sapiens cytochrome P450, family...    56   3e-07
AY514490-1|AAR89907.1|  490|Homo sapiens cytochrome P450, family...    56   3e-07
AY280372-1|AAQ21368.1|  519|Homo sapiens cytochrome P450 4A22 pr...    56   3e-07
AL359672-5|CAH71307.1|  490|Homo sapiens cytochrome P450, family...    56   3e-07
AF182274-1|AAF13599.1|  516|Homo sapiens cytochrome P450-1A2 pro...    56   3e-07
U02388-1|AAC50052.2|  520|Homo sapiens cytochrome P450 4F2 protein.    56   3e-07
U22029-1|AAB40520.1|  494|Homo sapiens cytochrome P450 protein.        55   5e-07
M21941-1|AAA52160.1|  480|Homo sapiens CYP2C protein.                  55   5e-07
AY792513-1|AAV40834.1|  520|Homo sapiens cytochrome P450, family...    55   5e-07
AF054821-1|AAC08589.1|  520|Homo sapiens cytochrome P-450 protein.     55   5e-07
X51535-1|CAA35915.1|  210|Homo sapiens cytochrome P-450 HPH (120...    54   8e-07
D26480-1|BAA05490.1|  520|Homo sapiens leukotriene B4 omega-hydr...    54   8e-07
D12620-1|BAA02144.1|  520|Homo sapiens cytochrome P-450LTBV prot...    54   8e-07
BC067440-1|AAH67440.1|  520|Homo sapiens cytochrome P450, family...    54   8e-07
BC067439-1|AAH67439.1|  520|Homo sapiens cytochrome P450, family...    54   8e-07
BC067437-1|AAH67437.1|  520|Homo sapiens cytochrome P450, family...    54   8e-07
AF467894-1|AAL67578.1|  520|Homo sapiens cytochrome P450, subfam...    54   8e-07
AC005336-1|AAC27730.1|  520|Homo sapiens CYP4F2 protein.               54   8e-07
AB015306-1|BAA75823.1|  520|Homo sapiens Leukotriene B4 omega-hy...    54   8e-07
AB002461-1|BAA25991.1|  520|Homo sapiens leukotriene B4 omega-hy...    54   8e-07
AB002454-1|BAA25990.1|  520|Homo sapiens leukotriene B4 omega-hy...    54   8e-07
BC033691-1|AAH33691.1|  504|Homo sapiens cytochrome P450, family...    54   1e-06
AY358603-1|AAQ88966.1|  504|Homo sapiens Cytochrome p450 protein.      54   1e-06
AK027605-1|BAB55227.1|  564|Homo sapiens protein ( Homo sapiens ...    54   1e-06
AF335278-1|AAK13498.1|  504|Homo sapiens cytochrome P450 2S1 pro...    54   1e-06
AY513609-1|AAR90940.1|  494|Homo sapiens cytochrome P450 2A13 va...    53   2e-06
AY513608-1|AAR90939.1|  494|Homo sapiens cytochrome P450 2A13 va...    53   2e-06
AY513606-1|AAR90937.1|  494|Homo sapiens cytochrome P450 2A13 va...    53   2e-06
AY513605-1|AAR90936.1|  494|Homo sapiens cytochrome P450 2A13 va...    53   2e-06
AY513604-1|AAR90935.1|  494|Homo sapiens cytochrome P450 2A13 va...    53   2e-06
AM233517-1|CAJ80720.1|  175|Homo sapiens cytochrome P450 1A1 pro...    53   2e-06
AF209774-1|AAG35775.1|  494|Homo sapiens cytochrome P450 2A13 pr...    53   2e-06
AL135960-10|CAI19737.1|  519|Homo sapiens cytochrome P450, famil...    52   4e-06
AF208532-1|AAF76722.1|  519|Homo sapiens fatty acid omega-hydrox...    52   4e-06
M80646-1|AAA60617.1|  460|Homo sapiens thromboxane synthase prot...    52   6e-06
M12078-1|AAA52154.1|  192|Homo sapiens POR protein.                    52   6e-06
BC109205-1|AAI09206.1|  512|Homo sapiens cytochrome P450, family...    52   6e-06
BC069443-1|AAH69443.1|  512|Homo sapiens cytochrome P450, family...    52   6e-06
AF252297-1|AAF76003.1|  512|Homo sapiens cytochrome P450 retinoi...    52   6e-06
AC007002-1|AAY14690.1|  512|Homo sapiens unknown protein.              52   6e-06
J02906-1|AAA52156.1|  491|Homo sapiens CYP2F1 protein.                 51   7e-06
BC035350-1|AAH35350.1|  524|Homo sapiens cytochrome P450, family...    51   7e-06
AY358977-1|AAQ89336.1|  524|Homo sapiens CYP4F12 protein.              51   7e-06
AY008841-1|AAG33247.1|  524|Homo sapiens cytochrome P450 isoform...    51   7e-06
AF372573-1|AAL69652.1|  495|Homo sapiens cytochrome P450 2F1 pro...    51   7e-06
AC004523-1|AAC11543.1|  458|Homo sapiens F22329_1 protein.             51   7e-06
AB035131-1|BAB18270.1|  524|Homo sapiens cytochrome P450 protein.      51   7e-06
AB035130-1|BAB18269.1|  524|Homo sapiens cytochrome P450 protein.      51   7e-06
X71480-1|CAA50586.1|  141|Homo sapiens cytochrome P450 protein.        51   1e-05
AK090886-1|BAC03539.1|  337|Homo sapiens protein ( Homo sapiens ...    51   1e-05
AY220845-1|AAO49806.1|  516|Homo sapiens cytochrome P450 protein.      50   1e-05
U22028-1|AAB40519.1|  494|Homo sapiens cytochrome P450 protein.        49   3e-05
BC128535-1|AAI28536.1|  143|Homo sapiens LOC283480 protein protein.    49   3e-05
BC001776-1|AAH01776.1|  217|Homo sapiens CYP27B1 protein protein.      48   7e-05
BC025761-1|AAH25761.2|  490|Homo sapiens cytochrome P450, family...    48   9e-05
AY871801-1|AAX62803.1|  483|Homo sapiens cytochrome P450 family ...    47   1e-04
L16883-1|AAD13467.1|  169|Homo sapiens cytochrome P-450 2C protein.    46   3e-04
BC093896-1|AAH93896.1|  531|Homo sapiens cytochrome P450, family...    46   3e-04
BC093894-1|AAH93894.1|  531|Homo sapiens cytochrome P450, family...    46   3e-04
BC069351-1|AAH69351.1|  531|Homo sapiens cytochrome P450, family...    46   3e-04
AK096820-1|BAC04868.1|  531|Homo sapiens protein ( Homo sapiens ...    46   3e-04
BC041158-1|AAH41158.1|  455|Homo sapiens CYP4A11 protein protein.      46   4e-04
AL731892-4|CAH72779.1|  455|Homo sapiens cytochrome P450, family...    46   4e-04
AB209700-1|BAD92937.1|  336|Homo sapiens cytochrome P450, family...    46   4e-04
K03192-1|AAA52147.1|  331|Homo sapiens CYP1A1 protein.                 45   5e-04
X56088-1|CAA39568.1|  504|Homo sapiens cholesterol  7-alpha-hydr...    45   6e-04
U56438-1|AAC50809.1|  543|Homo sapiens dioxin-inducible cytochro...    45   6e-04
U03688-1|AAA19567.1|  543|Homo sapiens cytochrome P450 protein.        45   6e-04
S77409-1|AAB34643.1|  228|Homo sapiens steroid 18-hydroxylase pr...    45   6e-04
M29874-1|AAA52144.1|  491|Homo sapiens CYP2B protein.                  45   6e-04
DQ298753-1|ABB84469.1|  491|Homo sapiens cytochrome P450, family...    45   6e-04
BT020001-1|AAV38804.1|  543|Homo sapiens cytochrome P450, family...    45   6e-04
BT019979-1|AAV38782.1|  543|Homo sapiens cytochrome P450, family...    45   6e-04
BC067430-1|AAH67430.1|  491|Homo sapiens cytochrome P450, family...    45   6e-04
BC012049-1|AAH12049.1|  543|Homo sapiens cytochrome P450, family...    45   6e-04
AY393998-1|AAQ87875.1|  543|Homo sapiens cytochrome P450, family...    45   6e-04
AF450132-1|AAM50512.1|  543|Homo sapiens cytochrome P450 CYP1B1 ...    45   6e-04
AF182277-1|AAF13602.1|  491|Homo sapiens cytochrome P450-2B6 pro...    45   6e-04
AC023172-1|AAF32444.1|  491|Homo sapiens CYP2B6 protein.               45   6e-04
AC009229-2|AAY15039.1|  543|Homo sapiens unknown protein.              45   6e-04
BC067431-1|AAH67431.1|  491|Homo sapiens cytochrome P450, family...    44   9e-04
M93133-1|AAA58435.1|  504|Homo sapiens cholesterol 7-alpha hydro...    44   0.001
BC112184-1|AAI12185.1|  504|Homo sapiens cytochrome P450, family...    44   0.001
BC101777-1|AAI01778.1|  504|Homo sapiens cytochrome P450, family...    44   0.001
DQ016495-1|AAY34975.1|  195|Homo sapiens cytochrome P450 1B1 pro...    43   0.003
AL135960-9|CAI19736.1|  421|Homo sapiens cytochrome P450, family...    42   0.006
AK127234-1|BAC86895.1|  130|Homo sapiens ).  protein.                  42   0.006
AL135960-11|CAI19738.1|  455|Homo sapiens cytochrome P450, famil...    41   0.008
AL591242-1|CAH73899.1|  469|Homo sapiens cytochrome P450, family...    41   0.011
AL035670-1|CAI20276.1|  469|Homo sapiens cytochrome P450, family...    41   0.011
AK127151-1|BAC86855.1|  146|Homo sapiens protein ( Homo sapiens ...    41   0.011
AF237982-1|AAF63329.1|  469|Homo sapiens oxysterol 7alpha-hydrox...    41   0.011
L36085-1|AAC01761.1|  441|Homo sapiens thromboxane A2 synthase p...    40   0.014
BC010358-1|AAH10358.1|  469|Homo sapiens cytochrome P450, family...    40   0.018
X58904-1|CAA41707.1|  371|Homo sapiens steroid 21-monooxygenase ...    40   0.024
X58902-1|CAA41706.1|  372|Homo sapiens steroid 21-monooxygenase ...    40   0.024
X58900-1|CAA41704.1|  372|Homo sapiens steroid 21-monooxygenase ...    40   0.024
X58899-1|CAA41703.1|  368|Homo sapiens steroid 21-monooxygenase ...    38   0.056
X58898-1|CAA41702.1|  371|Homo sapiens steroid 21-monooxygenase ...    38   0.056
BC096259-1|AAH96259.1|  443|Homo sapiens CYP2C18 protein protein.      38   0.056
AJ877238-1|CAI47002.1|   97|Homo sapiens putative cytochrome P45...    38   0.056
DQ680079-1|ABG25922.1|  347|Homo sapiens truncated cytochrome P4...    37   0.13 
AJ563379-2|CAD91649.1|   84|Homo sapiens cytochrome P450 protein.      37   0.13 
Z54367-1|CAA91196.1| 4684|Homo sapiens plectin protein.                36   0.23 
U63610-1|AAB05428.1| 4574|Homo sapiens plectin protein.                36   0.23 
U53204-1|AAB05427.1| 4574|Homo sapiens plectin protein.                36   0.23 
AY480051-1|AAR95684.1| 4547|Homo sapiens plectin 11 protein.           36   0.23 
AY480050-1|AAR95683.1| 4551|Homo sapiens plectin 10 protein.           36   0.23 
AY480049-1|AAR95682.1| 4547|Homo sapiens plectin 8 protein.            36   0.23 
AY480048-1|AAR95681.1| 4515|Homo sapiens plectin 7 protein.            36   0.23 
AY480047-1|AAR95680.1| 4684|Homo sapiens plectin 6 protein.            36   0.23 
AY480046-1|AAR95679.1| 4525|Homo sapiens plectin 3 protein.            36   0.23 
AY480045-1|AAR95678.1| 4533|Homo sapiens plectin 2 protein.            36   0.23 
AY480044-1|AAR95677.1| 4574|Homo sapiens plectin 1 protein.            36   0.23 
AM233518-1|CAJ80721.1|  157|Homo sapiens cytochrome P450 1A1 pro...    36   0.23 
AC004914-2|AAP21887.1|  311|Homo sapiens unknown protein.              36   0.23 
AC004914-1|AAD21788.1|  348|Homo sapiens unknown protein.              36   0.23 
AK000366-1|BAA91114.1|  408|Homo sapiens protein ( Homo sapiens ...    36   0.39 
BC067444-1|AAH67444.1|  501|Homo sapiens cytochrome P450, family...    35   0.52 
BC067442-1|AAH67442.1|  501|Homo sapiens cytochrome P450, family...    35   0.52 
AF090320-1|AAD19877.1|  501|Homo sapiens sterol 12-alpha-hydroxy...    35   0.52 
AF090318-1|AAC63037.1|  462|Homo sapiens sterol 12-alpha hydroxy...    35   0.52 
AK097373-1|BAC05026.1|  340|Homo sapiens protein ( Homo sapiens ...    35   0.69 
AF040259-1|AAD10199.1|  144|Homo sapiens cytochrome P450 1A1 pro...    35   0.69 
U77845-1|AAB52993.1|  469|Homo sapiens hTRIP protein.                  34   1.2  
BC067441-1|AAH67441.1|  501|Homo sapiens cytochrome P450, family...    34   1.2  
BC067434-1|AAH67434.1|  501|Homo sapiens cytochrome P450, family...    34   1.2  
BC019283-1|AAH19283.1|  469|Homo sapiens TRAF interacting protei...    33   2.1  
BC000310-1|AAH00310.1|  469|Homo sapiens TRAF interacting protei...    33   2.1  
AJ431381-1|CAD24089.1|  186|Homo sapiens steroid 11-beta-hydroxy...    33   2.1  
AF144566-1|AAD30164.1|  339|Homo sapiens cytochrome P450 epoxyge...    33   2.8  
M17398-1|AAA35740.1|  393|Homo sapiens protein ( Human cytochrom...    32   4.9  
AK094090-1|BAC04283.1|  153|Homo sapiens protein ( Homo sapiens ...    32   4.9  
X69292-1|CAA49154.1|  881|Homo sapiens smooth muscle mysosin  he...    31   8.5  
D10667-1|BAA36971.1| 1052|Homo sapiens smooth muscle myosin heav...    31   8.5  
BC104906-1|AAI04907.1| 1938|Homo sapiens myosin, heavy chain 11,...    31   8.5  
BC101677-1|AAI01678.1| 1938|Homo sapiens myosin, heavy chain 11,...    31   8.5  
AY520817-1|AAS98911.1| 1945|Homo sapiens smooth muscle myosin he...    31   8.5  
AY520816-1|AAS98910.1| 1979|Homo sapiens smooth muscle myosin he...    31   8.5  
AF001548-1|AAC31665.1| 1857|Homo sapiens Myosin heavy chain (MHY...    31   8.5  
AB020673-1|BAA74889.2| 1984|Homo sapiens KIAA0866 protein protein.     31   8.5  

>AY178622-1|AAO21126.1|  531|Homo sapiens steroid hydroxylase
           protein.
          Length = 531

 Score =  161 bits (391), Expect = 5e-39
 Identities = 111/371 (29%), Positives = 179/371 (48%), Gaps = 26/371 (7%)

Query: 81  KSENDRTDRPTGLVSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLR 140
           K   D+ D   G  +  G  W   R A+N  LL+P    LY+ A  EV  D + RL  LR
Sbjct: 134 KEHRDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLR 193

Query: 141 DEN---NRIRGQFDQEMNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVL 197
            E+   N++     Q    ++LE+I  +    R+ C   ++ +D+     +  +  MF  
Sbjct: 194 AESASGNQV-SDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVT--FVRSIGLMFQN 250

Query: 198 SNELDLKPSIWTYVSTPLFRKTMKMYEEQENLTKYFIKKALDDIKMNKSKSDDE----KP 253
           S      P  WT    P +++ +  +    +  K  I + L+D++     +  +      
Sbjct: 251 SLYATFLPK-WTRPVLPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAAGPDGIQVSG 309

Query: 254 VLEKLL---DINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMS-- 308
            L  LL    ++   A     ++L+AGVDTTSNT++  LY ++ + + Q+ L EEV+   
Sbjct: 310 YLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQKALHEEVVGVV 369

Query: 309 --------KN-GKRSYLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQ 359
                   K+      L+A +KE +R+ PVV  N R   KE  + G+  P+N    F H 
Sbjct: 370 PAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHY 429

Query: 360 HLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVET 419
            +S     +  P  F P RWL N S P      HPF + PFG+GVR+C+GRRIAELE++ 
Sbjct: 430 EVSRDPTAFSEPESFQPHRWLRN-SQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQL 488

Query: 420 FLSKIVENFQV 430
            L+++++ ++V
Sbjct: 489 LLARLIQKYKV 499


>M62401-1|AAA52142.1|  531|Homo sapiens sterol 27-hydroxylase
           protein.
          Length = 531

 Score =  160 bits (389), Expect = 8e-39
 Identities = 111/371 (29%), Positives = 179/371 (48%), Gaps = 26/371 (7%)

Query: 81  KSENDRTDRPTGLVSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLR 140
           K   D+ D   G  +  G  W   R A+N  LL+P    LY+ A  EV  D + RL  LR
Sbjct: 134 KEHRDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLR 193

Query: 141 DEN---NRIRGQFDQEMNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVL 197
            E+   N++     Q    ++LE+I  +    R+ C   ++ +D+     +  +  MF  
Sbjct: 194 AESASGNQV-SDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVT--FVRSIGLMFQN 250

Query: 198 SNELDLKPSIWTYVSTPLFRKTMKMYEEQENLTKYFIKKALDDIKMNKSKSDDE----KP 253
           S      P  WT    P +++ +  +    +  K  I + L+D++     +  +      
Sbjct: 251 SLYATFLPK-WTRPVLPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAAGPDGIQVSG 309

Query: 254 VLEKLL---DINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMS-- 308
            L  LL    ++   A     ++L+AGVDTTSNT++  LY ++ + + Q+ L EEV+   
Sbjct: 310 YLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVV 369

Query: 309 --------KN-GKRSYLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQ 359
                   K+      L+A +KE +R+ PVV  N R   KE  + G+  P+N    F H 
Sbjct: 370 PAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHY 429

Query: 360 HLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVET 419
            +S     +  P  F P RWL N S P      HPF + PFG+GVR+C+GRRIAELE++ 
Sbjct: 430 VVSRDPTAFSEPESFQPHRWLRN-SQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQL 488

Query: 420 FLSKIVENFQV 430
            L+++++ ++V
Sbjct: 489 LLARLIQKYKV 499


>BC051851-1|AAH51851.1|  531|Homo sapiens cytochrome P450, family
           27, subfamily A, polypeptide 1 protein.
          Length = 531

 Score =  160 bits (389), Expect = 8e-39
 Identities = 111/371 (29%), Positives = 179/371 (48%), Gaps = 26/371 (7%)

Query: 81  KSENDRTDRPTGLVSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLR 140
           K   D+ D   G  +  G  W   R A+N  LL+P    LY+ A  EV  D + RL  LR
Sbjct: 134 KEHRDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLR 193

Query: 141 DEN---NRIRGQFDQEMNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVL 197
            E+   N++     Q    ++LE+I  +    R+ C   ++ +D+     +  +  MF  
Sbjct: 194 AESASGNQV-SDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVT--FVRSIGLMFQN 250

Query: 198 SNELDLKPSIWTYVSTPLFRKTMKMYEEQENLTKYFIKKALDDIKMNKSKSDDE----KP 253
           S      P  WT    P +++ +  +    +  K  I + L+D++     +  +      
Sbjct: 251 SLYATFLPK-WTRPVLPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAAGPDGIQVSG 309

Query: 254 VLEKLL---DINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMS-- 308
            L  LL    ++   A     ++L+AGVDTTSNT++  LY ++ + + Q+ L EEV+   
Sbjct: 310 YLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVV 369

Query: 309 --------KN-GKRSYLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQ 359
                   K+      L+A +KE +R+ PVV  N R   KE  + G+  P+N    F H 
Sbjct: 370 PAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHY 429

Query: 360 HLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVET 419
            +S     +  P  F P RWL N S P      HPF + PFG+GVR+C+GRRIAELE++ 
Sbjct: 430 VVSRDPTAFSEPESFQPHRWLRN-SQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQL 488

Query: 420 FLSKIVENFQV 430
            L+++++ ++V
Sbjct: 489 LLARLIQKYKV 499


>BC040430-1|AAH40430.1|  531|Homo sapiens cytochrome P450, family
           27, subfamily A, polypeptide 1 protein.
          Length = 531

 Score =  160 bits (389), Expect = 8e-39
 Identities = 111/371 (29%), Positives = 179/371 (48%), Gaps = 26/371 (7%)

Query: 81  KSENDRTDRPTGLVSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLR 140
           K   D+ D   G  +  G  W   R A+N  LL+P    LY+ A  EV  D + RL  LR
Sbjct: 134 KEHRDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLR 193

Query: 141 DEN---NRIRGQFDQEMNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVL 197
            E+   N++     Q    ++LE+I  +    R+ C   ++ +D+     +  +  MF  
Sbjct: 194 AESASGNQV-SDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVT--FVRSIGLMFQN 250

Query: 198 SNELDLKPSIWTYVSTPLFRKTMKMYEEQENLTKYFIKKALDDIKMNKSKSDDE----KP 253
           S      P  WT    P +++ +  +    +  K  I + L+D++     +  +      
Sbjct: 251 SLYATFLPK-WTRPVLPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAAGPDGIQVSG 309

Query: 254 VLEKLL---DINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMS-- 308
            L  LL    ++   A     ++L+AGVDTTSNT++  LY ++ + + Q+ L EEV+   
Sbjct: 310 YLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVV 369

Query: 309 --------KN-GKRSYLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQ 359
                   K+      L+A +KE +R+ PVV  N R   KE  + G+  P+N    F H 
Sbjct: 370 PAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHY 429

Query: 360 HLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVET 419
            +S     +  P  F P RWL N S P      HPF + PFG+GVR+C+GRRIAELE++ 
Sbjct: 430 VVSRDPTAFSEPESFQPHRWLRN-SQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQL 488

Query: 420 FLSKIVENFQV 430
            L+++++ ++V
Sbjct: 489 LLARLIQKYKV 499


>X59812-1|CAA42481.1|  530|Homo sapiens Vitamin D3 25-hydroxylase
           protein.
          Length = 530

 Score =  159 bits (387), Expect = 1e-38
 Identities = 111/371 (29%), Positives = 179/371 (48%), Gaps = 26/371 (7%)

Query: 81  KSENDRTDRPTGLVSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLR 140
           K   D+ D   G  +  G  W   R A+N  LL+P    LY+ A  EV  D + RL  LR
Sbjct: 133 KEHRDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAERALYTDAFNEVIDDFMTRLDQLR 192

Query: 141 DEN---NRIRGQFDQEMNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVL 197
            E+   N++     Q    ++LE+I  +    R+ C   ++ +D+     +  +  MF  
Sbjct: 193 AESASGNQV-SDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVT--FVRSIGLMFQN 249

Query: 198 SNELDLKPSIWTYVSTPLFRKTMKMYEEQENLTKYFIKKALDDIKMNKSKSDDE----KP 253
           S      P  WT    P +++ +  +    +  K  I + L+D++     +  +      
Sbjct: 250 SLYATFLPK-WTRPVLPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAAGPDGIQVSG 308

Query: 254 VLEKLL---DINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMS-- 308
            L  LL    ++   A     ++L+AGVDTTSNT++  LY ++ + + Q+ L EEV+   
Sbjct: 309 YLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVV 368

Query: 309 --------KN-GKRSYLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQ 359
                   K+      L+A +KE +R+ PVV  N R   KE  + G+  P+N    F H 
Sbjct: 369 PAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHY 428

Query: 360 HLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVET 419
            +S     +  P  F P RWL N S P      HPF + PFG+GVR+C+GRRIAELE++ 
Sbjct: 429 VVSRDPTAFSEPESFQPHRWLRN-SQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQL 487

Query: 420 FLSKIVENFQV 430
            L+++++ ++V
Sbjct: 488 LLARLIQKYKV 498


>AY288916-1|AAP31972.1|  508|Homo sapiens cytochrome P450, family
           27, subfamily B, polypeptide 1 protein.
          Length = 508

 Score =  157 bits (380), Expect = 1e-37
 Identities = 120/400 (30%), Positives = 190/400 (47%), Gaps = 41/400 (10%)

Query: 56  ILRNENNMPIRISFKSLSYYRQKYKKSENDRTDRPTGLVSDHGELWKSFRSAVNPVLLQP 115
           +LR E   P R SF   + +R+  +        R  GL++  GE W+  RS + P+LL+P
Sbjct: 97  LLRQEGPRPERCSFSPWTEHRRCRQ--------RACGLLTAEGEEWQRLRSLLAPLLLRP 148

Query: 116 KTIRLYSSALEEVATDMVERLRSLRDENN---RIRGQFDQEMNLWSLESIGVVALGNRLN 172
           +    Y+  L  V  D+V RLR  R        +      E   + LE I  V LG+RL 
Sbjct: 149 QAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLG 208

Query: 173 CFDSNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVSTP-LFRKTMKMYEEQENLTK 231
           C ++ +  D+  +  I  V  +FV S  L +    W     P  + +  + +++     +
Sbjct: 209 CLEAQVPPDT--ETFIRAVGSVFV-STLLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFAQ 265

Query: 232 YFIKKALDDIKMNKS----KSDDEKPVLEKLLDINEEYAYIM---ASDMLVAGVDTTSNT 284
             +++   +  M       K  +    L   L   E  A  +    +++L+AGVDT SNT
Sbjct: 266 RHVERREAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNT 325

Query: 285 MSATLYLMAINQDKQQKLREEVMS--KNGKRSY-----------LRACIKEAMRILPVVS 331
           +S  LY ++ + + Q  L  E+ +    G  +Y           L+A +KE +R+ PVV 
Sbjct: 326 LSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVP 385

Query: 332 GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGN 391
           GN R   K+ ++  Y IP+N  +   H   S     +P P  F P RWL     P     
Sbjct: 386 GNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTP----- 440

Query: 392 AHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
            HPFA+ PFGFG RSC+GRR+AELE++  L++I+ +F+V+
Sbjct: 441 -HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQ 479


>AF256213-1|AAG00416.1|  508|Homo sapiens 25- hydroxyvitamin
           D-1-alpha-hydroxylase protein.
          Length = 508

 Score =  157 bits (380), Expect = 1e-37
 Identities = 120/400 (30%), Positives = 190/400 (47%), Gaps = 41/400 (10%)

Query: 56  ILRNENNMPIRISFKSLSYYRQKYKKSENDRTDRPTGLVSDHGELWKSFRSAVNPVLLQP 115
           +LR E   P R SF   + +R+  +        R  GL++  GE W+  RS + P+LL+P
Sbjct: 97  LLRQEGPRPERCSFSPWTEHRRCRQ--------RACGLLTAEGEEWQRLRSLLAPLLLRP 148

Query: 116 KTIRLYSSALEEVATDMVERLRSLRDENN---RIRGQFDQEMNLWSLESIGVVALGNRLN 172
           +    Y+  L  V  D+V RLR  R        +      E   + LE I  V LG+RL 
Sbjct: 149 QAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLG 208

Query: 173 CFDSNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVSTP-LFRKTMKMYEEQENLTK 231
           C ++ +  D+  +  I  V  +FV S  L +    W     P  + +  + +++     +
Sbjct: 209 CLEAQVPPDT--ETFIRAVGSVFV-STLLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFAQ 265

Query: 232 YFIKKALDDIKMNKS----KSDDEKPVLEKLLDINEEYAYIM---ASDMLVAGVDTTSNT 284
             +++   +  M       K  +    L   L   E  A  +    +++L+AGVDT SNT
Sbjct: 266 RHVERREAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNT 325

Query: 285 MSATLYLMAINQDKQQKLREEVMS--KNGKRSY-----------LRACIKEAMRILPVVS 331
           +S  LY ++ + + Q  L  E+ +    G  +Y           L+A +KE +R+ PVV 
Sbjct: 326 LSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVP 385

Query: 332 GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGN 391
           GN R   K+ ++  Y IP+N  +   H   S     +P P  F P RWL     P     
Sbjct: 386 GNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTP----- 440

Query: 392 AHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
            HPFA+ PFGFG RSC+GRR+AELE++  L++I+ +F+V+
Sbjct: 441 -HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQ 479


>AF246895-1|AAF64299.1|  508|Homo sapiens 25-hydroxyvitamin
           D-1-alpha-hydroxylase protein.
          Length = 508

 Score =  157 bits (380), Expect = 1e-37
 Identities = 120/400 (30%), Positives = 190/400 (47%), Gaps = 41/400 (10%)

Query: 56  ILRNENNMPIRISFKSLSYYRQKYKKSENDRTDRPTGLVSDHGELWKSFRSAVNPVLLQP 115
           +LR E   P R SF   + +R+  +        R  GL++  GE W+  RS + P+LL+P
Sbjct: 97  LLRQEGPRPERCSFSPWTEHRRCRQ--------RACGLLTAEGEEWQRLRSLLAPLLLRP 148

Query: 116 KTIRLYSSALEEVATDMVERLRSLRDENN---RIRGQFDQEMNLWSLESIGVVALGNRLN 172
           +    Y+  L  V  D+V RLR  R        +      E   + LE I  V LG+RL 
Sbjct: 149 QAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLG 208

Query: 173 CFDSNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVSTP-LFRKTMKMYEEQENLTK 231
           C ++ +  D+  +  I  V  +FV S  L +    W     P  + +  + +++     +
Sbjct: 209 CLEAQVPPDT--ETFIRAVGSVFV-STLLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFAQ 265

Query: 232 YFIKKALDDIKMNKS----KSDDEKPVLEKLLDINEEYAYIM---ASDMLVAGVDTTSNT 284
             +++   +  M       K  +    L   L   E  A  +    +++L+AGVDT SNT
Sbjct: 266 RHVERREAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNT 325

Query: 285 MSATLYLMAINQDKQQKLREEVMS--KNGKRSY-----------LRACIKEAMRILPVVS 331
           +S  LY ++ + + Q  L  E+ +    G  +Y           L+A +KE +R+ PVV 
Sbjct: 326 LSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVP 385

Query: 332 GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGN 391
           GN R   K+ ++  Y IP+N  +   H   S     +P P  F P RWL     P     
Sbjct: 386 GNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTP----- 440

Query: 392 AHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
            HPFA+ PFGFG RSC+GRR+AELE++  L++I+ +F+V+
Sbjct: 441 -HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQ 479


>AF027152-1|AAC51854.1|  508|Homo sapiens P450 25-hydroxyvitamin D-1
           alpha hydroxylase protein.
          Length = 508

 Score =  157 bits (380), Expect = 1e-37
 Identities = 120/400 (30%), Positives = 190/400 (47%), Gaps = 41/400 (10%)

Query: 56  ILRNENNMPIRISFKSLSYYRQKYKKSENDRTDRPTGLVSDHGELWKSFRSAVNPVLLQP 115
           +LR E   P R SF   + +R+  +        R  GL++  GE W+  RS + P+LL+P
Sbjct: 97  LLRQEGPRPERCSFSPWTEHRRCRQ--------RACGLLTAEGEEWQRLRSLLAPLLLRP 148

Query: 116 KTIRLYSSALEEVATDMVERLRSLRDENN---RIRGQFDQEMNLWSLESIGVVALGNRLN 172
           +    Y+  L  V  D+V RLR  R        +      E   + LE I  V LG+RL 
Sbjct: 149 QAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLG 208

Query: 173 CFDSNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVSTP-LFRKTMKMYEEQENLTK 231
           C ++ +  D+  +  I  V  +FV S  L +    W     P  + +  + +++     +
Sbjct: 209 CLEAQVPPDT--ETFIRAVGSVFV-STLLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFAQ 265

Query: 232 YFIKKALDDIKMNKS----KSDDEKPVLEKLLDINEEYAYIM---ASDMLVAGVDTTSNT 284
             +++   +  M       K  +    L   L   E  A  +    +++L+AGVDT SNT
Sbjct: 266 RHVERREAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNT 325

Query: 285 MSATLYLMAINQDKQQKLREEVMS--KNGKRSY-----------LRACIKEAMRILPVVS 331
           +S  LY ++ + + Q  L  E+ +    G  +Y           L+A +KE +R+ PVV 
Sbjct: 326 LSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVP 385

Query: 332 GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGN 391
           GN R   K+ ++  Y IP+N  +   H   S     +P P  F P RWL     P     
Sbjct: 386 GNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTP----- 440

Query: 392 AHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
            HPFA+ PFGFG RSC+GRR+AELE++  L++I+ +F+V+
Sbjct: 441 -HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQ 479


>AF020192-1|AAC51853.1|  508|Homo sapiens 25-hydroxyvitamin
           D-1-alpha-hydroxylase protein.
          Length = 508

 Score =  157 bits (380), Expect = 1e-37
 Identities = 120/400 (30%), Positives = 190/400 (47%), Gaps = 41/400 (10%)

Query: 56  ILRNENNMPIRISFKSLSYYRQKYKKSENDRTDRPTGLVSDHGELWKSFRSAVNPVLLQP 115
           +LR E   P R SF   + +R+  +        R  GL++  GE W+  RS + P+LL+P
Sbjct: 97  LLRQEGPRPERCSFSPWTEHRRCRQ--------RACGLLTAEGEEWQRLRSLLAPLLLRP 148

Query: 116 KTIRLYSSALEEVATDMVERLRSLRDENN---RIRGQFDQEMNLWSLESIGVVALGNRLN 172
           +    Y+  L  V  D+V RLR  R        +      E   + LE I  V LG+RL 
Sbjct: 149 QAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLG 208

Query: 173 CFDSNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVSTP-LFRKTMKMYEEQENLTK 231
           C ++ +  D+  +  I  V  +FV S  L +    W     P  + +  + +++     +
Sbjct: 209 CLEAQVPPDT--ETFIRAVGSVFV-STLLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFAQ 265

Query: 232 YFIKKALDDIKMNKS----KSDDEKPVLEKLLDINEEYAYIM---ASDMLVAGVDTTSNT 284
             +++   +  M       K  +    L   L   E  A  +    +++L+AGVDT SNT
Sbjct: 266 RHVERREAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNT 325

Query: 285 MSATLYLMAINQDKQQKLREEVMS--KNGKRSY-----------LRACIKEAMRILPVVS 331
           +S  LY ++ + + Q  L  E+ +    G  +Y           L+A +KE +R+ PVV 
Sbjct: 326 LSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVP 385

Query: 332 GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGN 391
           GN R   K+ ++  Y IP+N  +   H   S     +P P  F P RWL     P     
Sbjct: 386 GNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTP----- 440

Query: 392 AHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
            HPFA+ PFGFG RSC+GRR+AELE++  L++I+ +F+V+
Sbjct: 441 -HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQ 479


>AB006987-1|BAA23418.1|  508|Homo sapiens 25-hydroxyvitamin D3
           1-alpha-hydroxylase protein.
          Length = 508

 Score =  157 bits (380), Expect = 1e-37
 Identities = 120/400 (30%), Positives = 190/400 (47%), Gaps = 41/400 (10%)

Query: 56  ILRNENNMPIRISFKSLSYYRQKYKKSENDRTDRPTGLVSDHGELWKSFRSAVNPVLLQP 115
           +LR E   P R SF   + +R+  +        R  GL++  GE W+  RS + P+LL+P
Sbjct: 97  LLRQEGPRPERCSFSPWTEHRRCRQ--------RACGLLTAEGEEWQRLRSLLAPLLLRP 148

Query: 116 KTIRLYSSALEEVATDMVERLRSLRDENN---RIRGQFDQEMNLWSLESIGVVALGNRLN 172
           +    Y+  L  V  D+V RLR  R        +      E   + LE I  V LG+RL 
Sbjct: 149 QAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLG 208

Query: 173 CFDSNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVSTP-LFRKTMKMYEEQENLTK 231
           C ++ +  D+  +  I  V  +FV S  L +    W     P  + +  + +++     +
Sbjct: 209 CLEAQVPPDT--ETFIRAVGSVFV-STLLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFAQ 265

Query: 232 YFIKKALDDIKMNKS----KSDDEKPVLEKLLDINEEYAYIM---ASDMLVAGVDTTSNT 284
             +++   +  M       K  +    L   L   E  A  +    +++L+AGVDT SNT
Sbjct: 266 RHVERREAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNT 325

Query: 285 MSATLYLMAINQDKQQKLREEVMS--KNGKRSY-----------LRACIKEAMRILPVVS 331
           +S  LY ++ + + Q  L  E+ +    G  +Y           L+A +KE +R+ PVV 
Sbjct: 326 LSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVP 385

Query: 332 GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGN 391
           GN R   K+ ++  Y IP+N  +   H   S     +P P  F P RWL     P     
Sbjct: 386 GNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTP----- 440

Query: 392 AHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
            HPFA+ PFGFG RSC+GRR+AELE++  L++I+ +F+V+
Sbjct: 441 -HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQ 479


>AB005990-1|BAA22657.1|  508|Homo sapiens 25-hydroxyvitamin D3
           1alpha-hydroxylase protein.
          Length = 508

 Score =  157 bits (380), Expect = 1e-37
 Identities = 120/400 (30%), Positives = 190/400 (47%), Gaps = 41/400 (10%)

Query: 56  ILRNENNMPIRISFKSLSYYRQKYKKSENDRTDRPTGLVSDHGELWKSFRSAVNPVLLQP 115
           +LR E   P R SF   + +R+  +        R  GL++  GE W+  RS + P+LL+P
Sbjct: 97  LLRQEGPRPERCSFSPWTEHRRCRQ--------RACGLLTAEGEEWQRLRSLLAPLLLRP 148

Query: 116 KTIRLYSSALEEVATDMVERLRSLRDENN---RIRGQFDQEMNLWSLESIGVVALGNRLN 172
           +    Y+  L  V  D+V RLR  R        +      E   + LE I  V LG+RL 
Sbjct: 149 QAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLG 208

Query: 173 CFDSNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVSTP-LFRKTMKMYEEQENLTK 231
           C ++ +  D+  +  I  V  +FV S  L +    W     P  + +  + +++     +
Sbjct: 209 CLEAQVPPDT--ETFIRAVGSVFV-STLLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFAQ 265

Query: 232 YFIKKALDDIKMNKS----KSDDEKPVLEKLLDINEEYAYIM---ASDMLVAGVDTTSNT 284
             +++   +  M       K  +    L   L   E  A  +    +++L+AGVDT SNT
Sbjct: 266 RHVERREAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNT 325

Query: 285 MSATLYLMAINQDKQQKLREEVMS--KNGKRSY-----------LRACIKEAMRILPVVS 331
           +S  LY ++ + + Q  L  E+ +    G  +Y           L+A +KE +R+ PVV 
Sbjct: 326 LSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVP 385

Query: 332 GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGN 391
           GN R   K+ ++  Y IP+N  +   H   S     +P P  F P RWL     P     
Sbjct: 386 GNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTP----- 440

Query: 392 AHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
            HPFA+ PFGFG RSC+GRR+AELE++  L++I+ +F+V+
Sbjct: 441 -HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQ 479


>AB005989-1|BAA22656.1|  508|Homo sapiens 25-hydroxyvitamin D3
           1alpha-hydroxylase protein.
          Length = 508

 Score =  157 bits (380), Expect = 1e-37
 Identities = 120/400 (30%), Positives = 190/400 (47%), Gaps = 41/400 (10%)

Query: 56  ILRNENNMPIRISFKSLSYYRQKYKKSENDRTDRPTGLVSDHGELWKSFRSAVNPVLLQP 115
           +LR E   P R SF   + +R+  +        R  GL++  GE W+  RS + P+LL+P
Sbjct: 97  LLRQEGPRPERCSFSPWTEHRRCRQ--------RACGLLTAEGEEWQRLRSLLAPLLLRP 148

Query: 116 KTIRLYSSALEEVATDMVERLRSLRDENN---RIRGQFDQEMNLWSLESIGVVALGNRLN 172
           +    Y+  L  V  D+V RLR  R        +      E   + LE I  V LG+RL 
Sbjct: 149 QAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLG 208

Query: 173 CFDSNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVSTP-LFRKTMKMYEEQENLTK 231
           C ++ +  D+  +  I  V  +FV S  L +    W     P  + +  + +++     +
Sbjct: 209 CLEAQVPPDT--ETFIRAVGSVFV-STLLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFAQ 265

Query: 232 YFIKKALDDIKMNKS----KSDDEKPVLEKLLDINEEYAYIM---ASDMLVAGVDTTSNT 284
             +++   +  M       K  +    L   L   E  A  +    +++L+AGVDT SNT
Sbjct: 266 RHVERREAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNT 325

Query: 285 MSATLYLMAINQDKQQKLREEVMS--KNGKRSY-----------LRACIKEAMRILPVVS 331
           +S  LY ++ + + Q  L  E+ +    G  +Y           L+A +KE +R+ PVV 
Sbjct: 326 LSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVP 385

Query: 332 GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGN 391
           GN R   K+ ++  Y IP+N  +   H   S     +P P  F P RWL     P     
Sbjct: 386 GNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTP----- 440

Query: 392 AHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
            HPFA+ PFGFG RSC+GRR+AELE++  L++I+ +F+V+
Sbjct: 441 -HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQ 479


>AB005038-1|BAA23416.1|  508|Homo sapiens 25-hydroxyvitamin D3
           1-alpha-hydroxylase protein.
          Length = 508

 Score =  157 bits (380), Expect = 1e-37
 Identities = 120/400 (30%), Positives = 190/400 (47%), Gaps = 41/400 (10%)

Query: 56  ILRNENNMPIRISFKSLSYYRQKYKKSENDRTDRPTGLVSDHGELWKSFRSAVNPVLLQP 115
           +LR E   P R SF   + +R+  +        R  GL++  GE W+  RS + P+LL+P
Sbjct: 97  LLRQEGPRPERCSFSPWTEHRRCRQ--------RACGLLTAEGEEWQRLRSLLAPLLLRP 148

Query: 116 KTIRLYSSALEEVATDMVERLRSLRDENN---RIRGQFDQEMNLWSLESIGVVALGNRLN 172
           +    Y+  L  V  D+V RLR  R        +      E   + LE I  V LG+RL 
Sbjct: 149 QAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLG 208

Query: 173 CFDSNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVSTP-LFRKTMKMYEEQENLTK 231
           C ++ +  D+  +  I  V  +FV S  L +    W     P  + +  + +++     +
Sbjct: 209 CLEAQVPPDT--ETFIRAVGSVFV-STLLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFAQ 265

Query: 232 YFIKKALDDIKMNKS----KSDDEKPVLEKLLDINEEYAYIM---ASDMLVAGVDTTSNT 284
             +++   +  M       K  +    L   L   E  A  +    +++L+AGVDT SNT
Sbjct: 266 RHVERREAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNT 325

Query: 285 MSATLYLMAINQDKQQKLREEVMS--KNGKRSY-----------LRACIKEAMRILPVVS 331
           +S  LY ++ + + Q  L  E+ +    G  +Y           L+A +KE +R+ PVV 
Sbjct: 326 LSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVP 385

Query: 332 GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGN 391
           GN R   K+ ++  Y IP+N  +   H   S     +P P  F P RWL     P     
Sbjct: 386 GNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTP----- 440

Query: 392 AHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
            HPFA+ PFGFG RSC+GRR+AELE++  L++I+ +F+V+
Sbjct: 441 -HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQ 479


>AK131190-1|BAD18388.1|  372|Homo sapiens .-.-).  protein.
          Length = 372

 Score =  153 bits (370), Expect = 2e-36
 Identities = 103/354 (29%), Positives = 180/354 (50%), Gaps = 24/354 (6%)

Query: 105 RSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRD--ENNRIRGQFDQEMNLWSLESI 162
           RS +   +L+PK + +YS  + +V  D+++R+  LR   E+       +     +S+E +
Sbjct: 2   RSVLRQRILKPKDVAIYSGEVNQVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGV 61

Query: 163 GVVALGNRLNCFDSNL-QDDSPVKRLIECVHQMFVLSNELDLKPS-IWTYVSTPLFRKTM 220
             +   +RL C ++++ Q        +E +  MF  S      P  +  ++  P +R+  
Sbjct: 62  ATILYESRLGCLENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIPKP-WREFC 120

Query: 221 KMYEEQENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINE----EYAYIMASDMLVA 276
           + ++     ++  +   L DI+    +       L   L +++    +  Y   ++ML+A
Sbjct: 121 RSWDGLFKFSQIHVDNKLRDIQYQMDRGRRVSGGLLTYLFLSQALTLQEIYANVTEMLLA 180

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRSY-----------LRACIKEAMR 325
           GVDTTS T+S T+YL+A + + QQ +  E++   G+R             +RA +KE +R
Sbjct: 181 GVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLR 240

Query: 326 ILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSD 385
           + PV+ GN R T ++  I GY IP+   +A  H   S  ++ +PR  EF PERWL  K D
Sbjct: 241 LFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWL-RKGD 299

Query: 386 PLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVEWSGSSPRV 439
                    F + PFG GVRSCIGRRIAELE+   + +++++F+++ S  +  V
Sbjct: 300 ---LDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQTNAV 350


>BC039307-1|AAH39307.1|  372|Homo sapiens FLJ16008 protein protein.
          Length = 372

 Score =  152 bits (368), Expect = 3e-36
 Identities = 102/354 (28%), Positives = 180/354 (50%), Gaps = 24/354 (6%)

Query: 105 RSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRD--ENNRIRGQFDQEMNLWSLESI 162
           RS +   +L+PK + +YS  + +V  D+++R+  LR   E+       +     +S+E +
Sbjct: 2   RSVLRQRILKPKDVAIYSGEVNQVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGV 61

Query: 163 GVVALGNRLNCFDSNL-QDDSPVKRLIECVHQMFVLSNELDLKPS-IWTYVSTPLFRKTM 220
             +   +RL C ++++ Q        +E +  MF  S      P  +  ++  P +R+  
Sbjct: 62  ATILYESRLGCLENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIPKP-WREFC 120

Query: 221 KMYEEQENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINE----EYAYIMASDMLVA 276
           + ++     ++  +   L DI+    +       L   L +++    +  Y   ++ML+A
Sbjct: 121 RSWDGLFKFSQIHVDNKLRDIQYQMDRGRRVSGGLLTYLFLSQALTLQEIYANVTEMLLA 180

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRSY-----------LRACIKEAMR 325
           GVDTTS T+S T+Y++A + + QQ +  E++   G+R             +RA +KE +R
Sbjct: 181 GVDTTSFTLSWTVYILARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLR 240

Query: 326 ILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSD 385
           + PV+ GN R T ++  I GY IP+   +A  H   S  ++ +PR  EF PERWL  K D
Sbjct: 241 LFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWL-RKGD 299

Query: 386 PLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVEWSGSSPRV 439
                    F + PFG GVRSCIGRRIAELE+   + +++++F+++ S  +  V
Sbjct: 300 ---LDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQTNAV 350


>X05367-1|CAA28965.1|  521|Homo sapiens desmolase protein.
          Length = 521

 Score =  141 bits (342), Expect = 4e-33
 Identities = 118/443 (26%), Positives = 201/443 (45%), Gaps = 37/443 (8%)

Query: 6   HFMPGGSLHNINSTELTHKLYDIYGPIVRIDSMFSKDAIVLLYDAESAGIILRNENNMPI 65
           HF      H ++   + +  +  YGPI R + + + +++ ++ D E   ++ ++E   P 
Sbjct: 64  HFWRETGTHKVHLHHVQN--FQKYGPIYR-EKLGNVESVYVI-DPEDVALLFKSEGPNPE 119

Query: 66  RISFKSLSYYRQKYKKSENDRTDRPTGLVSDHGELWKSFRSAVNPVLLQPKTIRLYSSAL 125
           R        Y Q Y+        RP G++      WK  R A+N  ++ P+  + +   L
Sbjct: 120 RFLIPPWVAYHQYYQ--------RPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLL 171

Query: 126 EEVATDMVERL--RSLRDENNRIRGQFDQEMNLWSLESIGVVALGNRLNCFDSNLQDDSP 183
           + V+ D V  L  R  +  +    G    ++  ++ ESI  V  G R    +  +  ++ 
Sbjct: 172 DAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEA- 230

Query: 184 VKRLIECVHQMFVLSNE-LDLKPSIWTYVSTPLFRKTMKMYEEQENLTKYFIKKALDDIK 242
            +R I+ ++QMF  S   L+L P ++    T  ++  +  ++   +    + +    +++
Sbjct: 231 -QRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVILSKADIYTQNFYWELR 289

Query: 243 MNKSKSDDEKPVLEKLL-DINEEYAYIMAS--DMLVAGVDTTSNTMSATLYLMAINQDKQ 299
              S   D + +L +LL D    +  I A+  +ML  GVDTTS T+   LY MA N   Q
Sbjct: 290 QKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQ 349

Query: 300 QKLREEVMSKNGKRS-----------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHI 348
             LR EV++   +              L+A IKE +R+ P+     R    +  +  Y I
Sbjct: 350 DMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMI 409

Query: 349 PENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCI 408
           P    +  A   L     ++  P  F P RWL+   +  Y      F N  FG+GVR C+
Sbjct: 410 PAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITY------FRNLGFGWGVRQCL 463

Query: 409 GRRIAELEVETFLSKIVENFQVE 431
           GRRIAELE+  FL  ++ENF+VE
Sbjct: 464 GRRIAELEMTIFLINMLENFRVE 486


>BC032329-1|AAH32329.1|  521|Homo sapiens cytochrome P450, family
           11, subfamily A, polypeptide 1 protein.
          Length = 521

 Score =  141 bits (342), Expect = 4e-33
 Identities = 118/443 (26%), Positives = 201/443 (45%), Gaps = 37/443 (8%)

Query: 6   HFMPGGSLHNINSTELTHKLYDIYGPIVRIDSMFSKDAIVLLYDAESAGIILRNENNMPI 65
           HF      H ++   + +  +  YGPI R + + + +++ ++ D E   ++ ++E   P 
Sbjct: 64  HFWRETGTHKVHLHHVQN--FQKYGPIYR-EKLGNVESVYVI-DPEDVALLFKSEGPNPE 119

Query: 66  RISFKSLSYYRQKYKKSENDRTDRPTGLVSDHGELWKSFRSAVNPVLLQPKTIRLYSSAL 125
           R        Y Q Y+        RP G++      WK  R A+N  ++ P+  + +   L
Sbjct: 120 RFLIPPWVAYHQYYQ--------RPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLL 171

Query: 126 EEVATDMVERL--RSLRDENNRIRGQFDQEMNLWSLESIGVVALGNRLNCFDSNLQDDSP 183
           + V+ D V  L  R  +  +    G    ++  ++ ESI  V  G R    +  +  ++ 
Sbjct: 172 DAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEA- 230

Query: 184 VKRLIECVHQMFVLSNE-LDLKPSIWTYVSTPLFRKTMKMYEEQENLTKYFIKKALDDIK 242
            +R I+ ++QMF  S   L+L P ++    T  ++  +  ++   +    + +    +++
Sbjct: 231 -QRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELR 289

Query: 243 MNKSKSDDEKPVLEKLL-DINEEYAYIMAS--DMLVAGVDTTSNTMSATLYLMAINQDKQ 299
              S   D + +L +LL D    +  I A+  +ML  GVDTTS T+   LY MA N   Q
Sbjct: 290 QKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQ 349

Query: 300 QKLREEVMSKNGKRS-----------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHI 348
             LR EV++   +              L+A IKE +R+ P+     R    +  +  Y I
Sbjct: 350 DMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMI 409

Query: 349 PENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCI 408
           P    +  A   L     ++  P  F P RWL+   +  Y      F N  FG+GVR C+
Sbjct: 410 PAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITY------FRNLGFGWGVRQCL 463

Query: 409 GRRIAELEVETFLSKIVENFQVE 431
           GRRIAELE+  FL  ++ENF+VE
Sbjct: 464 GRRIAELEMTIFLINMLENFRVE 486


>M14565-1|AAA52162.1|  521|Homo sapiens CYP11A protein.
          Length = 521

 Score =  140 bits (340), Expect = 7e-33
 Identities = 118/443 (26%), Positives = 201/443 (45%), Gaps = 37/443 (8%)

Query: 6   HFMPGGSLHNINSTELTHKLYDIYGPIVRIDSMFSKDAIVLLYDAESAGIILRNENNMPI 65
           HF      H ++   + +  +  YGPI R + + + +++ ++ D E   ++ ++E   P 
Sbjct: 64  HFWRETGTHKVHLHHVQN--FQKYGPIYR-EKLGNVESVYVI-DPEDVALLFKSEGPNPE 119

Query: 66  RISFKSLSYYRQKYKKSENDRTDRPTGLVSDHGELWKSFRSAVNPVLLQPKTIRLYSSAL 125
           R        Y Q Y+        RP G++      WK  R A+N  ++ P+  + +   L
Sbjct: 120 RFLIPPWVAYHQYYQ--------RPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLL 171

Query: 126 EEVATDMVERL--RSLRDENNRIRGQFDQEMNLWSLESIGVVALGNRLNCFDSNLQDDSP 183
           + V+ D V  L  R  +  +    G    ++  ++ ESI  V  G R    +  +  ++ 
Sbjct: 172 DAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEA- 230

Query: 184 VKRLIECVHQMFVLSNE-LDLKPSIWTYVSTPLFRKTMKMYEEQENLTKYFIKKALDDIK 242
            +R I+ ++QMF  S   L+L P ++    T  ++  +  ++   +    + +    +++
Sbjct: 231 -QRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELR 289

Query: 243 MNKSKSDDEKPVLEKLL-DINEEYAYIMAS--DMLVAGVDTTSNTMSATLYLMAINQDKQ 299
              S   D + +L +LL D    +  I A+  +ML  GVDTTS T+   LY MA N   Q
Sbjct: 290 QKGSVHHDYRGMLYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQ 349

Query: 300 QKLREEVMSKNGKRS-----------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHI 348
             LR EV++   +              L+A IKE +R+ P+     R    +  +  Y I
Sbjct: 350 DMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMI 409

Query: 349 PENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCI 408
           P    +  A   L     ++  P  F P RWL+   +  Y      F N  FG+GVR C+
Sbjct: 410 PAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITY------FRNLGFGWGVRQCL 463

Query: 409 GRRIAELEVETFLSKIVENFQVE 431
           GRRIAELE+  FL  ++ENF+VE
Sbjct: 464 GRRIAELEMTIFLINMLENFRVE 486


>AL138805-3|CAB91829.1|  514|Homo sapiens cytochrome P450, family
           24, subfamily A, polypeptide 1 protein.
          Length = 514

 Score =  135 bits (327), Expect = 3e-31
 Identities = 108/395 (27%), Positives = 181/395 (45%), Gaps = 33/395 (8%)

Query: 56  ILRNENNMPIRISFKSLSYYRQKYKKSENDRTDRPTGLVSDHGELWKSFRSAVNPVLLQP 115
           + R E+  P R+  K    YR  Y+K          GL+   GE W+  RSA    L++P
Sbjct: 118 LYRTESAYPQRLEIKPWKAYRD-YRKEGY-------GLLILEGEDWQRVRSAFQKKLMKP 169

Query: 116 KTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQEMNLWSLESIGVVALGNRLNCFD 175
             +    + + EV  D + R+  L DE   +   +  E+N WS ESI +V    R     
Sbjct: 170 GEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYS-ELNKWSFESICLVLYEKRFGLLQ 228

Query: 176 SNLQDDSPVKRLIECVHQMFVLSNELDLKP-SIWTYVSTPLFRKTMKMYEEQENLTKYFI 234
            N  D++     I  +  M      + + P  +   ++T +++     ++      K  I
Sbjct: 229 KNAGDEAV--NFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACI 286

Query: 235 KKALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAI 294
              L+  K ++  S D    +     ++++  Y   +++ +A V+TT+N++   LY ++ 
Sbjct: 287 DNRLE--KYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSR 344

Query: 295 NQDKQQKLREEVMSKNGKRS-----------YLRACIKEAMRILPVVSGNMRRTTKEYNI 343
           N   QQKL +E+ S   +             YL+AC+KE+MR+ P V    R T  +  +
Sbjct: 345 NPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTR-TLDKATV 403

Query: 344 LG-YHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGF 402
           LG Y +P+   +    Q L   E  +   ++F PERWL  K         +PFA+ PFG 
Sbjct: 404 LGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKE------KINPFAHLPFGV 457

Query: 403 GVRSCIGRRIAELEVETFLSKIVENFQVEWSGSSP 437
           G R CIGRR+AEL++   L  IV  + ++ + + P
Sbjct: 458 GKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEP 492


>L13286-1|AAA62379.1|  513|Homo sapiens 1,25-dihydroxyvitamin D3
           24-hydroxylase protein.
          Length = 513

 Score =  133 bits (321), Expect = 1e-30
 Identities = 102/370 (27%), Positives = 173/370 (46%), Gaps = 25/370 (6%)

Query: 81  KSENDRTDRPTGLVSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLR 140
           K+  D      GL+   GE W+  RSA    L++P  +    + + EV  D + R+  L 
Sbjct: 134 KAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELC 193

Query: 141 DENNRIRGQFDQEMNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNE 200
           DE   +   +  E+N WS ESI +V    R      N  D++     I  +  M      
Sbjct: 194 DERGHVEDLYS-ELNKWSFESICLVLYEKRFGLLQKNAGDEAV--NFIMAIKTMMSTFGR 250

Query: 201 LDLKP-SIWTYVSTPLFRKTMKMYEEQENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLL 259
           + + P  +   ++T +++     ++      K  I   L+  K ++  S D    +    
Sbjct: 251 MMVTPVELHKSLNTKVWQGHTLAWDTIFKSVKACIDNRLE--KYSQQPSADFLCDIYHQN 308

Query: 260 DINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMS---KNGK---- 312
            ++++  Y   +++ +A V+TT+N++   LY ++ N   QQKL +E+ S   +N +    
Sbjct: 309 RLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQRPREE 368

Query: 313 ----RSYLRACIKEAMRILPVVSGNMRRTTKEYNILG-YHIPENVDIAFAHQHLSMMEKY 367
                 YL+AC+KE+MR+ P V    R T  +  +LG Y +P+   +    Q L   E  
Sbjct: 369 DLRNMPYLKACLKESMRLTPGVPFTTR-TLDKATVLGEYALPKGTVLMLNTQVLGSSEDN 427

Query: 368 YPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVEN 427
           +   ++F PERWL  K         +PFA+ PFG G R CIGRR+AEL++   L  IV  
Sbjct: 428 FEDSSQFRPERWLQEKE------KINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRK 481

Query: 428 FQVEWSGSSP 437
           + ++ + + P
Sbjct: 482 YDIQATDNEP 491


>AY858838-1|AAW50795.1|  372|Homo sapiens vitamin D 24-hydroxylase
           splice variant protein.
          Length = 372

 Score =  130 bits (314), Expect = 1e-29
 Identities = 97/353 (27%), Positives = 165/353 (46%), Gaps = 25/353 (7%)

Query: 98  GELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQEMNLW 157
           GE W+  RSA    L++P  +    + + EV  D + R+  L DE   +   +  E+N W
Sbjct: 10  GEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYS-ELNKW 68

Query: 158 SLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNELDLKP-SIWTYVSTPLF 216
           S ESI +V    R      N  D++     I  +  M      + + P  +   ++T ++
Sbjct: 69  SFESICLVLYEKRFGLLQKNAGDEAV--NFIMAIKTMMSTFGRMMVTPVELHKSLNTKVW 126

Query: 217 RKTMKMYEEQENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVA 276
           +     ++      K  I   L+  K ++  S D    +     ++++  Y   +++ +A
Sbjct: 127 QDHTLAWDTIFKSVKACIDNRLE--KYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLA 184

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRACIKEAMR 325
            V+TT+N++   LY ++ N   QQKL +E+ S   +             YL+AC+KE+MR
Sbjct: 185 AVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMR 244

Query: 326 ILPVVSGNMRRTTKEYNILG-YHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           + P V    R T  +  +LG Y +P+   +    Q L   E  +   ++F PERWL  K 
Sbjct: 245 LTPSVPFTTR-TLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKE 303

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVEWSGSSP 437
                   +PFA+ PFG G R CIGRR+AEL++   L  IV  + ++ + + P
Sbjct: 304 ------KINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEP 350


>AL138805-1|CAM27342.1|  372|Homo sapiens cytochrome P450, family
           24, subfamily A, polypeptide 1 protein.
          Length = 372

 Score =  130 bits (314), Expect = 1e-29
 Identities = 97/353 (27%), Positives = 165/353 (46%), Gaps = 25/353 (7%)

Query: 98  GELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQEMNLW 157
           GE W+  RSA    L++P  +    + + EV  D + R+  L DE   +   +  E+N W
Sbjct: 10  GEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYS-ELNKW 68

Query: 158 SLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNELDLKP-SIWTYVSTPLF 216
           S ESI +V    R      N  D++     I  +  M      + + P  +   ++T ++
Sbjct: 69  SFESICLVLYEKRFGLLQKNAGDEAV--NFIMAIKTMMSTFGRMMVTPVELHKSLNTKVW 126

Query: 217 RKTMKMYEEQENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVA 276
           +     ++      K  I   L+  K ++  S D    +     ++++  Y   +++ +A
Sbjct: 127 QDHTLAWDTIFKSVKACIDNRLE--KYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLA 184

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRACIKEAMR 325
            V+TT+N++   LY ++ N   QQKL +E+ S   +             YL+AC+KE+MR
Sbjct: 185 AVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMR 244

Query: 326 ILPVVSGNMRRTTKEYNILG-YHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           + P V    R T  +  +LG Y +P+   +    Q L   E  +   ++F PERWL  K 
Sbjct: 245 LTPSVPFTTR-TLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKE 303

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVEWSGSSP 437
                   +PFA+ PFG G R CIGRR+AEL++   L  IV  + ++ + + P
Sbjct: 304 ------KINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEP 350


>D13752-1|BAA02899.1|  503|Homo sapiens steroid 18-hydroxylase
           protein.
          Length = 503

 Score =  112 bits (269), Expect = 3e-24
 Identities = 108/425 (25%), Positives = 189/425 (44%), Gaps = 35/425 (8%)

Query: 23  HKLYDIYGPIVRIDSMFSKDAIVLLYDAESAGIILRNENNMPIRISFKSLSYYRQKYKKS 82
           H+ +   GPI R +    +   V+L   E    + + ++  P R+  +    YRQ     
Sbjct: 69  HQTFQELGPIFRYNLGGPRMVCVML--PEDVEKLQQVDSLHPCRMILEPWVAYRQ----- 121

Query: 83  ENDRTDRPTGLVSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDE 142
                    G+   +G  W+  R  +NP +L PK ++ +   ++ VA D  + L+    +
Sbjct: 122 ---HRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQ 178

Query: 143 NNRIRGQFDQEMNL--WSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNE 200
           N R     D + ++  +++E+  +   G RL     +    S     +  +  MF  + +
Sbjct: 179 NARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHS--PSSASLNFLHALEVMFKSTVQ 236

Query: 201 LDLKP-SIWTYVSTPLFRKTMKMYEEQENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLL 259
           L   P S+  ++S  ++++  + ++         I+K   ++  N+ +      V E LL
Sbjct: 237 LMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGI-VAELLL 295

Query: 260 DINEEYAYIMASDM-LVAG-VDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS--- 314
                   I A+ M L AG VDTT+  +  TL+ +A N D QQ LR+E ++     S   
Sbjct: 296 KAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHP 355

Query: 315 --------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEK 366
                    LRA +KE +R+ PV     R  + +  +  YHIP    +      L     
Sbjct: 356 QKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAA 415

Query: 367 YYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVE 426
            +PRP  + P+RWL  +      G+   F + PFGFG+R C+GRR+AE E+   L  +++
Sbjct: 416 LFPRPERYNPQRWLDIR------GSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469

Query: 427 NFQVE 431
           +F VE
Sbjct: 470 HFLVE 474


>X54741-1|CAA38539.1|  503|Homo sapiens aldosterone  synthase
           (P-450aldo) protein.
          Length = 503

 Score =  110 bits (264), Expect = 1e-23
 Identities = 107/425 (25%), Positives = 188/425 (44%), Gaps = 35/425 (8%)

Query: 23  HKLYDIYGPIVRIDSMFSKDAIVLLYDAESAGIILRNENNMPIRISFKSLSYYRQKYKKS 82
           H+ +   GPI R +    +   V+L   E    + + ++  P R+  +    YRQ     
Sbjct: 69  HQTFQELGPIFRYNLGGPRMVCVML--PEDVEKLQQVDSLHPCRMILEPWVAYRQ----- 121

Query: 83  ENDRTDRPTGLVSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDE 142
                    G+   +G  W+  R  +NP +L PK ++ +   ++ VA D  + L+    +
Sbjct: 122 ---HRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQ 178

Query: 143 NNRIRGQFDQEMNL--WSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNE 200
           N R     D + ++  +++E+  +   G RL     +    S     +  +  MF  + +
Sbjct: 179 NARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHS--PSSASLNFLHALEVMFKSTVQ 236

Query: 201 LDLKP-SIWTYVSTPLFRKTMKMYEEQENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLL 259
           L   P S+  ++   ++++  + ++         I+K   ++  N+ +      V E LL
Sbjct: 237 LMFMPRSLSRWIRPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGI-VAELLL 295

Query: 260 DINEEYAYIMASDM-LVAG-VDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS--- 314
                   I A+ M L AG VDTT+  +  TL+ +A N D QQ LR+E ++     S   
Sbjct: 296 KAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHP 355

Query: 315 --------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEK 366
                    LRA +KE +R+ PV     R  + +  +  YHIP    +      L     
Sbjct: 356 QKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAA 415

Query: 367 YYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVE 426
            +PRP  + P+RWL  +      G+   F + PFGFG+R C+GRR+AE E+   L  +++
Sbjct: 416 LFPRPERYNPQRWLDIR------GSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469

Query: 427 NFQVE 431
           +F VE
Sbjct: 470 HFLVE 474


>M32881-1|AAA35741.1|  503|Homo sapiens protein ( Human steroid
           11-beta-hydroxylase-like-enzyme (CYP11B2) gene, exon 9.
           ).
          Length = 503

 Score =  109 bits (263), Expect = 2e-23
 Identities = 94/351 (26%), Positives = 161/351 (45%), Gaps = 25/351 (7%)

Query: 97  HGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQEMNL 156
           +G  W+  R  +NP +L PK ++ +   ++ VA D  + LR    +N R     D + ++
Sbjct: 133 NGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALRKKVLQNARGSLTLDVQPSI 192

Query: 157 --WSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNELDLKP-SIWTYVST 213
             +++E+  +   G RL     +    S     +  +  MF  + +L   P S+  ++S 
Sbjct: 193 FHYTIEASNLALFGERLGLVGHS--PSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISP 250

Query: 214 PLFRKTMKMYEEQENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMASDM 273
            ++++  + ++         I+K   ++  N+ +      V E LL        I A+ M
Sbjct: 251 KVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGI-VAELLLKAELSLEAIKANSM 309

Query: 274 -LVAG-VDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRACI 320
            L AG VDTT+  +  TL+ +A N D QQ LR+E ++     S            LRA +
Sbjct: 310 ELTAGSVDTTAFPLLMTLFELARNPDVQQILRKESLAAAASISEHPQKATTELPLLRAAL 369

Query: 321 KEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWL 380
           KE +R+ PV     R  + +  +  YHIP    +      L      +PRP  + P+RWL
Sbjct: 370 KETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWL 429

Query: 381 TNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
             +      G+     + PFGFG+R C+GRR+AE E+   L  +++ F VE
Sbjct: 430 DIR------GSGRNLHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKRFLVE 474


>X55764-1|CAA39290.1|  503|Homo sapiens protein ( Human mRNA for
           cytochrome P-450 (11 Beta). ).
          Length = 503

 Score =  109 bits (261), Expect = 3e-23
 Identities = 107/425 (25%), Positives = 188/425 (44%), Gaps = 35/425 (8%)

Query: 23  HKLYDIYGPIVRIDSMFSKDAIVLLYDAESAGIILRNENNMPIRISFKSLSYYRQKYKKS 82
           H+ +   GPI R D   +    V+L   E    + + ++  P R+S +    YRQ     
Sbjct: 69  HQTFQELGPIFRYDLGGAGMVCVML--PEDVEKLQQVDSLHPHRMSLEPWVAYRQ----- 121

Query: 83  ENDRTDRPTGLVSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDE 142
                    G+   +G  W+  R  +NP +L P  ++ +   ++ VA D  + L+    +
Sbjct: 122 ---HRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQ 178

Query: 143 NNRIRGQFDQEMNL--WSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNE 200
           N R     D + ++  +++E+  +   G RL     +    S     +  +  MF  + +
Sbjct: 179 NARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHS--PSSASLNFLHALEVMFKSTVQ 236

Query: 201 LDLKP-SIWTYVSTPLFRKTMKMYEEQENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLL 259
           L   P S+  + S  ++++  + ++         I+K   ++  ++ +      V E LL
Sbjct: 237 LMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSI-VAELLL 295

Query: 260 DINEEYAYIMASDM-LVAG-VDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS--- 314
           +       I A+ M L AG VDTT   +  TL+ +A N + QQ LR+E ++     S   
Sbjct: 296 NAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHP 355

Query: 315 --------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEK 366
                    LRA +KE +R+ PV     R  + +  +  YHIP    +      L     
Sbjct: 356 QKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVRVFLYSLGRNPA 415

Query: 367 YYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVE 426
            +PRP  + P+RWL  +      G+   F + PFGFG+R C+GRR+AE E+   L  +++
Sbjct: 416 LFPRPERYNPQRWLDIR------GSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469

Query: 427 NFQVE 431
           + QVE
Sbjct: 470 HLQVE 474


>M32879-1|AAA52149.1|  503|Homo sapiens CYP11B1 protein.
          Length = 503

 Score =  109 bits (261), Expect = 3e-23
 Identities = 107/425 (25%), Positives = 188/425 (44%), Gaps = 35/425 (8%)

Query: 23  HKLYDIYGPIVRIDSMFSKDAIVLLYDAESAGIILRNENNMPIRISFKSLSYYRQKYKKS 82
           H+ +   GPI R D   +    V+L   E    + + ++  P R+S +    YRQ     
Sbjct: 69  HQTFQELGPIFRYDLGGAGMVCVML--PEDVEKLQQVDSLHPHRMSLEPWVAYRQ----- 121

Query: 83  ENDRTDRPTGLVSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDE 142
                    G+   +G  W+  R  +NP +L P  ++ +   ++ VA D  + L+    +
Sbjct: 122 ---HRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQ 178

Query: 143 NNRIRGQFDQEMNL--WSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNE 200
           N R     D + ++  +++E+  +   G RL     +    S     +  +  MF  + +
Sbjct: 179 NARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHS--PSSASLNFLHALEVMFKSTVQ 236

Query: 201 LDLKP-SIWTYVSTPLFRKTMKMYEEQENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLL 259
           L   P S+  + S  ++++  + ++         I+K   ++  ++ +      V E LL
Sbjct: 237 LMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSI-VAELLL 295

Query: 260 DINEEYAYIMASDM-LVAG-VDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS--- 314
           +       I A+ M L AG VDTT   +  TL+ +A N + QQ LR+E ++     S   
Sbjct: 296 NAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHP 355

Query: 315 --------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEK 366
                    LRA +KE +R+ PV     R  + +  +  YHIP    +      L     
Sbjct: 356 QKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPA 415

Query: 367 YYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVE 426
            +PRP  + P+RWL  +      G+   F + PFGFG+R C+GRR+AE E+   L  +++
Sbjct: 416 LFPRPERYNPQRWLDIR------GSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469

Query: 427 NFQVE 431
           + QVE
Sbjct: 470 HLQVE 474


>BC096287-1|AAH96287.1|  503|Homo sapiens cytochrome P450, family
           11, subfamily B, polypeptide 1 protein.
          Length = 503

 Score =  109 bits (261), Expect = 3e-23
 Identities = 107/425 (25%), Positives = 188/425 (44%), Gaps = 35/425 (8%)

Query: 23  HKLYDIYGPIVRIDSMFSKDAIVLLYDAESAGIILRNENNMPIRISFKSLSYYRQKYKKS 82
           H+ +   GPI R D   +    V+L   E    + + ++  P R+S +    YRQ     
Sbjct: 69  HQTFQELGPIFRYDLGGAGMVCVML--PEDVEKLQQVDSLHPHRMSLEPWVAYRQ----- 121

Query: 83  ENDRTDRPTGLVSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDE 142
                    G+   +G  W+  R  +NP +L P  ++ +   ++ VA D  + L+    +
Sbjct: 122 ---HRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQ 178

Query: 143 NNRIRGQFDQEMNL--WSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNE 200
           N R     D + ++  +++E+  +   G RL     +    S     +  +  MF  + +
Sbjct: 179 NARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHS--PSSASLNFLHALEVMFKSTVQ 236

Query: 201 LDLKP-SIWTYVSTPLFRKTMKMYEEQENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLL 259
           L   P S+  + S  ++++  + ++         I+K   ++  ++ +      V E LL
Sbjct: 237 LMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSI-VAELLL 295

Query: 260 DINEEYAYIMASDM-LVAG-VDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS--- 314
           +       I A+ M L AG VDTT   +  TL+ +A N + QQ LR+E ++     S   
Sbjct: 296 NAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHP 355

Query: 315 --------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEK 366
                    LRA +KE +R+ PV     R  + +  +  YHIP    +      L     
Sbjct: 356 QKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPA 415

Query: 367 YYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVE 426
            +PRP  + P+RWL  +      G+   F + PFGFG+R C+GRR+AE E+   L  +++
Sbjct: 416 LFPRPERYNPQRWLDIR------GSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469

Query: 427 NFQVE 431
           + QVE
Sbjct: 470 HLQVE 474


>AF478474-1|AAL84813.1|  503|Homo sapiens mutated cytochrome
           P-450c11 protein protein.
          Length = 503

 Score =  107 bits (258), Expect = 6e-23
 Identities = 106/425 (24%), Positives = 188/425 (44%), Gaps = 35/425 (8%)

Query: 23  HKLYDIYGPIVRIDSMFSKDAIVLLYDAESAGIILRNENNMPIRISFKSLSYYRQKYKKS 82
           H+ +   GPI R D   +    V+L   E    + + ++  P R+S +    YRQ     
Sbjct: 69  HQTFQELGPIFRYDLGGAGMVCVML--PEDVEKLQQVDSLHPHRMSLEPWVAYRQ----- 121

Query: 83  ENDRTDRPTGLVSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDE 142
                    G+   +G  W+  R  +NP +L P  ++ +   ++ VA D  + L+    +
Sbjct: 122 ---HRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQ 178

Query: 143 NNRIRGQFDQEMNL--WSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNE 200
           N R     D + ++  +++E+  +   G RL     +    S     +  +  MF  + +
Sbjct: 179 NARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHS--PSSASLNFLHALEVMFKSTVQ 236

Query: 201 LDLKP-SIWTYVSTPLFRKTMKMYEEQENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLL 259
           L   P S+  + S  ++++  + ++         I+K   ++  ++ +      V E LL
Sbjct: 237 LMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSI-VAELLL 295

Query: 260 DINEEYAYIMASDM-LVAG-VDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS--- 314
           +       I A+ M L AG +DTT   +  TL+ +A N + QQ LR+E ++     S   
Sbjct: 296 NAELSPDAIKANSMELTAGSMDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHP 355

Query: 315 --------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEK 366
                    LRA +KE +R+ PV     R  + +  +  YHIP    +      L     
Sbjct: 356 QKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPA 415

Query: 367 YYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVE 426
            +PRP  + P+RWL  +      G+   F + PFGFG+R C+GRR+AE E+   L  +++
Sbjct: 416 LFPRPERYNPQRWLDIR------GSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469

Query: 427 NFQVE 431
           + QVE
Sbjct: 470 HLQVE 474


>BC096285-1|AAH96285.1|  574|Homo sapiens CYP11B1 protein protein.
          Length = 574

 Score =  106 bits (255), Expect = 1e-22
 Identities = 93/358 (25%), Positives = 163/358 (45%), Gaps = 25/358 (6%)

Query: 90  PTGLVSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQ 149
           PT     +G  W+  R  +NP +L P  ++ +   ++ VA D  + L+    +N R    
Sbjct: 197 PTHSGCRNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLT 256

Query: 150 FDQEMNL--WSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNELDLKP-S 206
            D + ++  +++E+  +   G RL     +    S     +  +  MF  + +L   P S
Sbjct: 257 LDVQPSIFHYTIEASNLALFGERLGLVGHS--PSSASLNFLHALEVMFKSTVQLMFMPRS 314

Query: 207 IWTYVSTPLFRKTMKMYEEQENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYA 266
           +  + S  ++++  + ++         I+K   ++  ++ +      V E LL+      
Sbjct: 315 LSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSI-VAELLLNAELSPD 373

Query: 267 YIMASDM-LVAG-VDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS---------- 314
            I A+ M L AG VDTT   +  TL+ +A N + QQ LR+E ++     S          
Sbjct: 374 AIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTEL 433

Query: 315 -YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTE 373
             LRA +KE +R+ PV     R  + +  +  YHIP    +      L      +PRP  
Sbjct: 434 PLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPER 493

Query: 374 FIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
           + P+RWL  +      G+   F + PFGFG+R C+GRR+AE E+   L  ++++ QVE
Sbjct: 494 YNPQRWLDIR------GSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVE 545


>S67623-1|AAB29308.1|  257|Homo sapiens 25-hydroxyvitamin D
           24-hydroxylase cytochrome P450 subunit protein.
          Length = 257

 Score = 98.3 bits (234), Expect = 5e-20
 Identities = 61/189 (32%), Positives = 100/189 (52%), Gaps = 19/189 (10%)

Query: 261 INEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS------ 314
           ++++  Y   +++ +A V+TT+N++   LY ++ N   QQKL +E+ S   +        
Sbjct: 54  LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAED 113

Query: 315 -----YLRACIKEAMRILPVVSGNMRRTTKEYNILG-YHIPENVDIAFAHQHLSMMEKYY 368
                YL+AC+KE+MR+ P V    R T  +  +LG Y +P+   +    Q L   E  +
Sbjct: 114 LRNMPYLKACLKESMRLTPSVPFTTR-TLDKATVLGEYALPKGTVLMLNTQVLGSSEDNF 172

Query: 369 PRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
              ++F PERWL  K         +PFA+ PFG G R CIGRR+AEL++   L  IV  +
Sbjct: 173 EDSSQFRPERWLQEKE------KINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKY 226

Query: 429 QVEWSGSSP 437
            ++ + + P
Sbjct: 227 DIQATDNEP 235


>M28253-1|AAA36404.1|  239|Homo sapiens cytochrome P-450-scc
           protein.
          Length = 239

 Score = 95.5 bits (227), Expect = 3e-19
 Identities = 70/206 (33%), Positives = 100/206 (48%), Gaps = 20/206 (9%)

Query: 240 DIKMNKSKSDDEKPVLEKLL-DINEEYAYIMAS--DMLVAGVDTTSNTMSATLYLMAINQ 296
           +++   S   D + +L +LL D    +  I A+  +ML  GVDTTS T+   LY MA N 
Sbjct: 5   ELRQKGSVHHDYRGMLYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNL 64

Query: 297 DKQQKLREEVMSKNGKRS-----------YLRACIKEAMRILPVVSGNMRRTTKEYNILG 345
             Q  LR EV++   +              L+A IKE +R+ P+     R    +  +  
Sbjct: 65  KVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRD 124

Query: 346 YHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVR 405
           Y IP    +  A   L     ++  P  F P RWL+   +  Y      F N  FG+GVR
Sbjct: 125 YMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITY------FRNLGFGWGVR 178

Query: 406 SCIGRRIAELEVETFLSKIVENFQVE 431
            C+GRRIAELE+  FL  ++ENF+VE
Sbjct: 179 QCLGRRIAELEMTIFLINMLENFRVE 204


>M18907-1|AAA35745.1|  503|Homo sapiens protein ( Human P450 mRNA
           encoding nifedipine oxidase, complete cds. ).
          Length = 503

 Score = 87.0 bits (206), Expect = 1e-16
 Identities = 64/229 (27%), Positives = 106/229 (46%), Gaps = 24/229 (10%)

Query: 213 TPLFRKTMKMYEEQ--ENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMA 270
           T   RK++K  +E   E+  K+ +      I    SK  +    L  L  + +   +I A
Sbjct: 246 TNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA 305

Query: 271 SDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRAC 319
                 G +TTS+ +S  +Y +A + D QQKL+EE+ +    ++           YL   
Sbjct: 306 ------GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMV 359

Query: 320 IKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERW 379
           + E +R+ P+     R   K+  I G  IP+ V +      L    KY+  P +F+PER+
Sbjct: 360 VNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF 419

Query: 380 LTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
                D     N  P+  +PFG G R+CIG R A + ++  L ++++NF
Sbjct: 420 SKKNKD-----NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463


>DQ924960-1|ABI96208.1|  503|Homo sapiens cytochrome P450 family 3
           subfamily A polypeptide 4 protein.
          Length = 503

 Score = 87.0 bits (206), Expect = 1e-16
 Identities = 64/229 (27%), Positives = 106/229 (46%), Gaps = 24/229 (10%)

Query: 213 TPLFRKTMKMYEEQ--ENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMA 270
           T   RK++K  +E   E+  K+ +      I    SK  +    L  L  + +   +I A
Sbjct: 246 TNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA 305

Query: 271 SDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRAC 319
                 G +TTS+ +S  +Y +A + D QQKL+EE+ +    ++           YL   
Sbjct: 306 ------GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMV 359

Query: 320 IKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERW 379
           + E +R+ P+     R   K+  I G  IP+ V +      L    KY+  P +F+PER+
Sbjct: 360 VNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF 419

Query: 380 LTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
                D     N  P+  +PFG G R+CIG R A + ++  L ++++NF
Sbjct: 420 SKKNKD-----NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463


>DQ005611-1|AAY16980.1|  503|Homo sapiens cytochrome P450, family 3,
           subfamily A, polypeptide 4 protein.
          Length = 503

 Score = 87.0 bits (206), Expect = 1e-16
 Identities = 64/229 (27%), Positives = 106/229 (46%), Gaps = 24/229 (10%)

Query: 213 TPLFRKTMKMYEEQ--ENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMA 270
           T   RK++K  +E   E+  K+ +      I    SK  +    L  L  + +   +I A
Sbjct: 246 TNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA 305

Query: 271 SDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRAC 319
                 G +TTS+ +S  +Y +A + D QQKL+EE+ +    ++           YL   
Sbjct: 306 ------GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMV 359

Query: 320 IKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERW 379
           + E +R+ P+     R   K+  I G  IP+ V +      L    KY+  P +F+PER+
Sbjct: 360 VNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF 419

Query: 380 LTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
                D     N  P+  +PFG G R+CIG R A + ++  L ++++NF
Sbjct: 420 SKKNKD-----NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463


>BC101631-1|AAI01632.1|  503|Homo sapiens cytochrome P450, subfamily
           IIIA, polypeptide 4 protein.
          Length = 503

 Score = 87.0 bits (206), Expect = 1e-16
 Identities = 64/229 (27%), Positives = 106/229 (46%), Gaps = 24/229 (10%)

Query: 213 TPLFRKTMKMYEEQ--ENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMA 270
           T   RK++K  +E   E+  K+ +      I    SK  +    L  L  + +   +I A
Sbjct: 246 TNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA 305

Query: 271 SDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRAC 319
                 G +TTS+ +S  +Y +A + D QQKL+EE+ +    ++           YL   
Sbjct: 306 ------GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMV 359

Query: 320 IKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERW 379
           + E +R+ P+     R   K+  I G  IP+ V +      L    KY+  P +F+PER+
Sbjct: 360 VNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF 419

Query: 380 LTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
                D     N  P+  +PFG G R+CIG R A + ++  L ++++NF
Sbjct: 420 SKKNKD-----NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463


>BC069418-1|AAH69418.1|  503|Homo sapiens cytochrome P450, family 3,
           subfamily A, polypeptide 4 protein.
          Length = 503

 Score = 87.0 bits (206), Expect = 1e-16
 Identities = 64/229 (27%), Positives = 106/229 (46%), Gaps = 24/229 (10%)

Query: 213 TPLFRKTMKMYEEQ--ENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMA 270
           T   RK++K  +E   E+  K+ +      I    SK  +    L  L  + +   +I A
Sbjct: 246 TNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA 305

Query: 271 SDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRAC 319
                 G +TTS+ +S  +Y +A + D QQKL+EE+ +    ++           YL   
Sbjct: 306 ------GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMV 359

Query: 320 IKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERW 379
           + E +R+ P+     R   K+  I G  IP+ V +      L    KY+  P +F+PER+
Sbjct: 360 VNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF 419

Query: 380 LTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
                D     N  P+  +PFG G R+CIG R A + ++  L ++++NF
Sbjct: 420 SKKNKD-----NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463


>AJ563377-1|CAD91345.1|  353|Homo sapiens cytochrome P450 protein.
          Length = 353

 Score = 87.0 bits (206), Expect = 1e-16
 Identities = 64/229 (27%), Positives = 106/229 (46%), Gaps = 24/229 (10%)

Query: 213 TPLFRKTMKMYEEQ--ENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMA 270
           T   RK++K  +E   E+  K+ +      I    SK  +    L  L  + +   +I A
Sbjct: 96  TNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA 155

Query: 271 SDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRAC 319
                 G +TTS+ +S  +Y +A + D QQKL+EE+ +    ++           YL   
Sbjct: 156 ------GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMV 209

Query: 320 IKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERW 379
           + E +R+ P+     R   K+  I G  IP+ V +      L    KY+  P +F+PER+
Sbjct: 210 VNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF 269

Query: 380 LTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
                D     N  P+  +PFG G R+CIG R A + ++  L ++++NF
Sbjct: 270 SKKNKD-----NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 313


>AJ563376-2|CAD91645.1|  430|Homo sapiens cytochrome P450 protein.
          Length = 430

 Score = 87.0 bits (206), Expect = 1e-16
 Identities = 64/229 (27%), Positives = 106/229 (46%), Gaps = 24/229 (10%)

Query: 213 TPLFRKTMKMYEEQ--ENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMA 270
           T   RK++K  +E   E+  K+ +      I    SK  +    L  L  + +   +I A
Sbjct: 173 TNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA 232

Query: 271 SDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRAC 319
                 G +TTS+ +S  +Y +A + D QQKL+EE+ +    ++           YL   
Sbjct: 233 ------GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMV 286

Query: 320 IKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERW 379
           + E +R+ P+     R   K+  I G  IP+ V +      L    KY+  P +F+PER+
Sbjct: 287 VNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF 346

Query: 380 LTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
                D     N  P+  +PFG G R+CIG R A + ++  L ++++NF
Sbjct: 347 SKKNKD-----NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 390


>AJ563375-1|CAD91343.1|  503|Homo sapiens cytochrome P450 protein.
          Length = 503

 Score = 87.0 bits (206), Expect = 1e-16
 Identities = 64/229 (27%), Positives = 106/229 (46%), Gaps = 24/229 (10%)

Query: 213 TPLFRKTMKMYEEQ--ENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMA 270
           T   RK++K  +E   E+  K+ +      I    SK  +    L  L  + +   +I A
Sbjct: 246 TNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA 305

Query: 271 SDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRAC 319
                 G +TTS+ +S  +Y +A + D QQKL+EE+ +    ++           YL   
Sbjct: 306 ------GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMV 359

Query: 320 IKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERW 379
           + E +R+ P+     R   K+  I G  IP+ V +      L    KY+  P +F+PER+
Sbjct: 360 VNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF 419

Query: 380 LTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
                D     N  P+  +PFG G R+CIG R A + ++  L ++++NF
Sbjct: 420 SKKNKD-----NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463


>AF280107-2|AAG32290.1|  503|Homo sapiens cytochrome P450
           polypeptide 4 protein.
          Length = 503

 Score = 87.0 bits (206), Expect = 1e-16
 Identities = 64/229 (27%), Positives = 106/229 (46%), Gaps = 24/229 (10%)

Query: 213 TPLFRKTMKMYEEQ--ENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMA 270
           T   RK++K  +E   E+  K+ +      I    SK  +    L  L  + +   +I A
Sbjct: 246 TNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA 305

Query: 271 SDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRAC 319
                 G +TTS+ +S  +Y +A + D QQKL+EE+ +    ++           YL   
Sbjct: 306 ------GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMV 359

Query: 320 IKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERW 379
           + E +R+ P+     R   K+  I G  IP+ V +      L    KY+  P +F+PER+
Sbjct: 360 VNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF 419

Query: 380 LTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
                D     N  P+  +PFG G R+CIG R A + ++  L ++++NF
Sbjct: 420 SKKNKD-----NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463


>AF209389-1|AAF21034.1|  503|Homo sapiens cytochrome P450 IIIA4
           protein.
          Length = 503

 Score = 87.0 bits (206), Expect = 1e-16
 Identities = 64/229 (27%), Positives = 106/229 (46%), Gaps = 24/229 (10%)

Query: 213 TPLFRKTMKMYEEQ--ENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMA 270
           T   RK++K  +E   E+  K+ +      I    SK  +    L  L  + +   +I A
Sbjct: 246 TNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA 305

Query: 271 SDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRAC 319
                 G +TTS+ +S  +Y +A + D QQKL+EE+ +    ++           YL   
Sbjct: 306 ------GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMV 359

Query: 320 IKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERW 379
           + E +R+ P+     R   K+  I G  IP+ V +      L    KY+  P +F+PER+
Sbjct: 360 VNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF 419

Query: 380 LTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
                D     N  P+  +PFG G R+CIG R A + ++  L ++++NF
Sbjct: 420 SKKNKD-----NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463


>AF182273-1|AAF13598.1|  503|Homo sapiens cytochrome P450-3A4
           protein.
          Length = 503

 Score = 87.0 bits (206), Expect = 1e-16
 Identities = 64/229 (27%), Positives = 106/229 (46%), Gaps = 24/229 (10%)

Query: 213 TPLFRKTMKMYEEQ--ENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMA 270
           T   RK++K  +E   E+  K+ +      I    SK  +    L  L  + +   +I A
Sbjct: 246 TNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA 305

Query: 271 SDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRAC 319
                 G +TTS+ +S  +Y +A + D QQKL+EE+ +    ++           YL   
Sbjct: 306 ------GCETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMV 359

Query: 320 IKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERW 379
           + E +R+ P+     R   K+  I G  IP+ V +      L    KY+  P +F+PER+
Sbjct: 360 VNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF 419

Query: 380 LTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
                D     N  P+  +PFG G R+CIG R A + ++  L ++++NF
Sbjct: 420 SKKNKD-----NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463


>BC109084-1|AAI09085.1|  448|Homo sapiens CYP24A1 protein protein.
          Length = 448

 Score = 85.8 bits (203), Expect = 3e-16
 Identities = 78/309 (25%), Positives = 138/309 (44%), Gaps = 25/309 (8%)

Query: 56  ILRNENNMPIRISFKSLSYYRQKYKKSENDRTDRPTGLVSDHGELWKSFRSAVNPVLLQP 115
           + R E+  P R+  K    YR  Y+K          GL+   GE W+  RSA    L++P
Sbjct: 118 LYRTESAYPQRLEIKPWKAYRD-YRKEGY-------GLLILEGEDWQRVRSAFQKKLMKP 169

Query: 116 KTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQEMNLWSLESIGVVALGNRLNCFD 175
             +    + + EV  D + R+  L DE   +   +  E+N WS ESI +V    R     
Sbjct: 170 GEVMKLDNKINEVLADFMGRIDELCDERGHVEDLY-SELNKWSFESICLVLYEKRFGLLQ 228

Query: 176 SNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVSTPLFRKTMKMYEEQENLTKYFIK 235
            N  D++ V  ++     M      +     +   ++T +++     ++      K  I 
Sbjct: 229 KNAGDEA-VNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACID 287

Query: 236 KALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAIN 295
             L+  K ++  S D    +     ++++  Y   +++ +A V+TT+N++   LY ++ N
Sbjct: 288 NRLE--KYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRN 345

Query: 296 QDKQQKLREEVMS---KN--------GKRSYLRACIKEAMRILPVVSGNMRRTTKEYNIL 344
              QQKL +E+ S   +N            YL+AC+KE+MR+ P V     RT  +  +L
Sbjct: 346 PQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFT-TRTLDKATVL 404

Query: 345 G-YHIPENV 352
           G Y +P+ +
Sbjct: 405 GEYALPKGI 413


>BC109083-1|AAI09084.1|  448|Homo sapiens CYP24A1 protein protein.
          Length = 448

 Score = 85.8 bits (203), Expect = 3e-16
 Identities = 78/309 (25%), Positives = 138/309 (44%), Gaps = 25/309 (8%)

Query: 56  ILRNENNMPIRISFKSLSYYRQKYKKSENDRTDRPTGLVSDHGELWKSFRSAVNPVLLQP 115
           + R E+  P R+  K    YR  Y+K          GL+   GE W+  RSA    L++P
Sbjct: 118 LYRTESAYPQRLEIKPWKAYRD-YRKEGY-------GLLILEGEDWQRVRSAFQKKLMKP 169

Query: 116 KTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQEMNLWSLESIGVVALGNRLNCFD 175
             +    + + EV  D + R+  L DE   +   +  E+N WS ESI +V    R     
Sbjct: 170 GEVMKLDNKINEVLADFMGRIDELCDERGHVEDLY-SELNKWSFESICLVLYEKRFGLLQ 228

Query: 176 SNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVSTPLFRKTMKMYEEQENLTKYFIK 235
            N  D++ V  ++     M      +     +   ++T +++     ++      K  I 
Sbjct: 229 KNAGDEA-VNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACID 287

Query: 236 KALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAIN 295
             L+  K ++  S D    +     ++++  Y   +++ +A V+TT+N++   LY ++ N
Sbjct: 288 NRLE--KYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRN 345

Query: 296 QDKQQKLREEVMS---KN--------GKRSYLRACIKEAMRILPVVSGNMRRTTKEYNIL 344
              QQKL +E+ S   +N            YL+AC+KE+MR+ P V     RT  +  +L
Sbjct: 346 PQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFT-TRTLDKATVL 404

Query: 345 G-YHIPENV 352
           G Y +P+ +
Sbjct: 405 GEYALPKGI 413


>AL138805-2|CAM27343.1|  448|Homo sapiens cytochrome P450, family
           24, subfamily A, polypeptide 1 protein.
          Length = 448

 Score = 85.8 bits (203), Expect = 3e-16
 Identities = 78/309 (25%), Positives = 138/309 (44%), Gaps = 25/309 (8%)

Query: 56  ILRNENNMPIRISFKSLSYYRQKYKKSENDRTDRPTGLVSDHGELWKSFRSAVNPVLLQP 115
           + R E+  P R+  K    YR  Y+K          GL+   GE W+  RSA    L++P
Sbjct: 118 LYRTESAYPQRLEIKPWKAYRD-YRKEGY-------GLLILEGEDWQRVRSAFQKKLMKP 169

Query: 116 KTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQEMNLWSLESIGVVALGNRLNCFD 175
             +    + + EV  D + R+  L DE   +   +  E+N WS ESI +V    R     
Sbjct: 170 GEVMKLDNKINEVLADFMGRIDELCDERGHVEDLY-SELNKWSFESICLVLYEKRFGLLQ 228

Query: 176 SNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVSTPLFRKTMKMYEEQENLTKYFIK 235
            N  D++ V  ++     M      +     +   ++T +++     ++      K  I 
Sbjct: 229 KNAGDEA-VNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACID 287

Query: 236 KALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAIN 295
             L+  K ++  S D    +     ++++  Y   +++ +A V+TT+N++   LY ++ N
Sbjct: 288 NRLE--KYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRN 345

Query: 296 QDKQQKLREEVMS---KN--------GKRSYLRACIKEAMRILPVVSGNMRRTTKEYNIL 344
              QQKL +E+ S   +N            YL+AC+KE+MR+ P V     RT  +  +L
Sbjct: 346 PQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFT-TRTLDKATVL 404

Query: 345 G-YHIPENV 352
           G Y +P+ +
Sbjct: 405 GEYALPKGI 413


>BC060857-1|AAH60857.1|  525|Homo sapiens cytochrome P450, family 4,
           subfamily V, polypeptide 2 protein.
          Length = 525

 Score = 85.0 bits (201), Expect = 5e-16
 Identities = 60/198 (30%), Positives = 93/198 (46%), Gaps = 23/198 (11%)

Query: 246 SKSDDEKPVLEKLLDINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREE 305
           S +DDE   L    DI EE         +  G DTT+  ++ +LYL+  N + Q+K+  E
Sbjct: 305 SVTDDEGNRLSHE-DIREE-----VDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHE 358

Query: 306 VMSKNGKRS------------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVD 353
           +    GK              YL   IKE +R+ P V    R  +++  + GY + +  +
Sbjct: 359 LDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTE 418

Query: 354 IAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIA 413
                  L    +Y+P P EF PER+    +        HP+A  PF  G R+CIG++ A
Sbjct: 419 AVIIPYALHRDPRYFPNPEEFQPERFFPENAQ-----GRHPYAYVPFSAGPRNCIGQKFA 473

Query: 414 ELEVETFLSKIVENFQVE 431
            +E +T LS I+ +F +E
Sbjct: 474 VMEEKTILSCILRHFWIE 491


>AY422002-1|AAR31180.1|  525|Homo sapiens cytochrome P450 4V2
           protein.
          Length = 525

 Score = 85.0 bits (201), Expect = 5e-16
 Identities = 60/198 (30%), Positives = 93/198 (46%), Gaps = 23/198 (11%)

Query: 246 SKSDDEKPVLEKLLDINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREE 305
           S +DDE   L    DI EE         +  G DTT+  ++ +LYL+  N + Q+K+  E
Sbjct: 305 SVTDDEGNRLSHE-DIREE-----VDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHE 358

Query: 306 VMSKNGKRS------------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVD 353
           +    GK              YL   IKE +R+ P V    R  +++  + GY + +  +
Sbjct: 359 LDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTE 418

Query: 354 IAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIA 413
                  L    +Y+P P EF PER+    +        HP+A  PF  G R+CIG++ A
Sbjct: 419 AVIIPYALHRDPRYFPNPEEFQPERFFPENAQ-----GRHPYAYVPFSAGPRNCIGQKFA 473

Query: 414 ELEVETFLSKIVENFQVE 431
            +E +T LS I+ +F +E
Sbjct: 474 VMEEKTILSCILRHFWIE 491


>AK126473-1|BAC86562.1|  503|Homo sapiens protein ( Homo sapiens
           cDNA FLJ44509 fis, clone UTERU3001585, weakly  similar
           to Cytochrome P450 4c3 (EC 1.14.-.-). ).
          Length = 503

 Score = 85.0 bits (201), Expect = 5e-16
 Identities = 60/198 (30%), Positives = 93/198 (46%), Gaps = 23/198 (11%)

Query: 246 SKSDDEKPVLEKLLDINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREE 305
           S +DDE   L    DI EE         +  G DTT+  ++ +LYL+  N + Q+K+  E
Sbjct: 283 SVTDDEGNRLSHE-DIREE-----VDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHE 336

Query: 306 VMSKNGKRS------------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVD 353
           +    GK              YL   IKE +R+ P V    R  +++  + GY + +  +
Sbjct: 337 LDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTE 396

Query: 354 IAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIA 413
                  L    +Y+P P EF PER+    +        HP+A  PF  G R+CIG++ A
Sbjct: 397 AVIIPYALHRDPRYFPNPEEFQPERFFPENAQ-----GRHPYAYVPFSAGPRNCIGQKFA 451

Query: 414 ELEVETFLSKIVENFQVE 431
            +E +T LS I+ +F +E
Sbjct: 452 VMEEKTILSCILRHFWIE 469


>AK122600-1|BAC85487.1|  525|Homo sapiens protein ( Homo sapiens
           cDNA FLJ16007 fis, clone KIDNE2006580, weakly  similar
           to CYTOCHROME P450 4C1 (EC 1.14.14.1). ).
          Length = 525

 Score = 85.0 bits (201), Expect = 5e-16
 Identities = 60/198 (30%), Positives = 93/198 (46%), Gaps = 23/198 (11%)

Query: 246 SKSDDEKPVLEKLLDINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREE 305
           S +DDE   L    DI EE         +  G DTT+  ++ +LYL+  N + Q+K+  E
Sbjct: 305 SVTDDEGNRLSHE-DIREE-----VDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHE 358

Query: 306 VMSKNGKRS------------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVD 353
           +    GK              YL   IKE +R+ P V    R  +++  + GY + +  +
Sbjct: 359 LDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTE 418

Query: 354 IAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIA 413
                  L    +Y+P P EF PER+    +        HP+A  PF  G R+CIG++ A
Sbjct: 419 AVIIPYALHRDPRYFPNPEEFQPERFFPENAQ-----GRHPYAYVPFSAGPRNCIGQKFA 473

Query: 414 ELEVETFLSKIVENFQVE 431
            +E +T LS I+ +F +E
Sbjct: 474 VMEEKTILSCILRHFWIE 491


>M14096-1|AAA35744.1|  503|Homo sapiens protein ( Human cytochrome
           P-450 nifedipine oxidase mRNA, complet cds. ).
          Length = 503

 Score = 84.6 bits (200), Expect = 7e-16
 Identities = 63/229 (27%), Positives = 105/229 (45%), Gaps = 24/229 (10%)

Query: 213 TPLFRKTMKMYEEQ--ENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMA 270
           T   RK++K  +E   E+  K+ +      I    SK  +    L  L  + +   +I A
Sbjct: 246 TNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA 305

Query: 271 SDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRAC 319
                 G +TTS+ +S  +Y +A + D QQKL+EE+ +    ++           YL   
Sbjct: 306 ------GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMV 359

Query: 320 IKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERW 379
           + E +R+ P+     R   K+  I G  IP+   +      L    KY+  P +F+PER+
Sbjct: 360 VNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERF 419

Query: 380 LTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
                D     N  P+  +PFG G R+CIG R A + ++  L ++++NF
Sbjct: 420 SKKNKD-----NIDPYTYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463


>J04449-1|AAA35747.1|  502|Homo sapiens cytochrome P450 nifedipine
           oxidase protein.
          Length = 502

 Score = 84.6 bits (200), Expect = 7e-16
 Identities = 63/229 (27%), Positives = 105/229 (45%), Gaps = 24/229 (10%)

Query: 213 TPLFRKTMKMYEEQ--ENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMA 270
           T   RK++K  +E   E+  K+ +      I    SK  +    L  L  + +   +I A
Sbjct: 245 TNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA 304

Query: 271 SDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRAC 319
                 G +TTS+ +S  +Y +A + D QQKL+EE+ +    ++           YL   
Sbjct: 305 ------GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMV 358

Query: 320 IKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERW 379
           + E +R+ P+     R   K+  I G  IP+   +      L    KY+  P +F+PER+
Sbjct: 359 VNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERF 418

Query: 380 LTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
                D     N  P+  +PFG G R+CIG R A + ++  L ++++NF
Sbjct: 419 SKKNKD-----NIDPYTYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 462


>X12387-1|CAA30944.1|  503|Homo sapiens protein ( Human mRNA for
           cytochrome P-450 (cyp3 locus). ).
          Length = 503

 Score = 84.2 bits (199), Expect = 9e-16
 Identities = 63/229 (27%), Positives = 105/229 (45%), Gaps = 24/229 (10%)

Query: 213 TPLFRKTMKMYEEQ--ENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMA 270
           T   RK++K  +E   E+  K+ +      I    SK  +    L  L  + +   +I A
Sbjct: 246 TNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA 305

Query: 271 SDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRAC 319
                 G +TTS+ +S  +Y +A + D QQKL+EE+ +    ++           YL   
Sbjct: 306 ------GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMV 359

Query: 320 IKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERW 379
           + E +R+ P+     R   K+  I G  IP+   +      L    KY+  P +F+PER+
Sbjct: 360 VNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERF 419

Query: 380 LTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
                D     N  P+  +PFG G R+CIG R A + ++  L ++++NF
Sbjct: 420 SKKNKD-----NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463


>M13785-1|AAA35742.1|  504|Homo sapiens protein ( Human liver
           glucocorticoid-inducible cytochrome P-450 (HLp) mRNA,
           complete cds. ).
          Length = 504

 Score = 83.8 bits (198), Expect = 1e-15
 Identities = 65/232 (28%), Positives = 108/232 (46%), Gaps = 29/232 (12%)

Query: 213 TPLFRKTMKMYEEQ--ENLTKY---FIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAY 267
           T   RK +K  +E   E+  K+   F++  +D  K   SK  +    L  L  + +   +
Sbjct: 246 TNFLRKAVKRMKESRLEDTQKHRVDFLQLMIDSHK--NSKETESHKALSDLELVAQSIIF 303

Query: 268 IMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YL 316
           I A      G +TTS+ +S  +Y +A + D QQKL+EE+ +    ++           YL
Sbjct: 304 IFA------GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYL 357

Query: 317 RACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIP 376
              + E +R+ P+     R   K+  I G  IP+   +      L    KY+  P +F+P
Sbjct: 358 DMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLP 417

Query: 377 ERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
           ER+     D     N  P+  +PFG G R+CIG R A + ++  L ++++NF
Sbjct: 418 ERFSKKNKD-----NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 464


>D00003-1|BAA00001.1|  504|Homo sapiens cytochrome P-450 protein.
          Length = 504

 Score = 83.8 bits (198), Expect = 1e-15
 Identities = 65/232 (28%), Positives = 108/232 (46%), Gaps = 29/232 (12%)

Query: 213 TPLFRKTMKMYEEQ--ENLTKY---FIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAY 267
           T   RK +K  +E   E+  K+   F++  +D  K   SK  +    L  L  + +   +
Sbjct: 246 TNFLRKAVKRMKESRLEDTQKHRVDFLQLMIDSHK--NSKETESHKALSDLELVAQSIIF 303

Query: 268 IMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YL 316
           I A      G +TTS+ +S  +Y +A + D QQKL+EE+ +    ++           YL
Sbjct: 304 IFA------GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYL 357

Query: 317 RACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIP 376
              + E +R+ P+     R   K+  I G  IP+   +      L    KY+  P +F+P
Sbjct: 358 DMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLP 417

Query: 377 ERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
           ER+     D     N  P+  +PFG G R+CIG R A + ++  L ++++NF
Sbjct: 418 ERFSKKNKD-----NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 464


>J04813-1|AAA02993.1|  502|Homo sapiens cytochrome P450 PCN3
           protein.
          Length = 502

 Score = 82.2 bits (194), Expect = 3e-15
 Identities = 53/166 (31%), Positives = 85/166 (51%), Gaps = 17/166 (10%)

Query: 274 LVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRACIKE 322
           + AG +TTS+ +S TLY +A + D QQKL++E+ +    ++           YL   + E
Sbjct: 303 IFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNE 362

Query: 323 AMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTN 382
            +R+ PV     R   K+  I G  IP+   +      L    KY+  P EF PER+ + 
Sbjct: 363 TLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF-SK 421

Query: 383 KSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
           K D +      P+  +PFG G R+CIG R A + ++  L ++++NF
Sbjct: 422 KKDSI-----DPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462


>BC033862-1|AAH33862.1|  502|Homo sapiens cytochrome P450, family 3,
           subfamily A, polypeptide 5 protein.
          Length = 502

 Score = 82.2 bits (194), Expect = 3e-15
 Identities = 53/166 (31%), Positives = 85/166 (51%), Gaps = 17/166 (10%)

Query: 274 LVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRACIKE 322
           + AG +TTS+ +S TLY +A + D QQKL++E+ +    ++           YL   + E
Sbjct: 303 IFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNE 362

Query: 323 AMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTN 382
            +R+ PV     R   K+  I G  IP+   +      L    KY+  P EF PER+ + 
Sbjct: 363 TLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF-SK 421

Query: 383 KSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
           K D +      P+  +PFG G R+CIG R A + ++  L ++++NF
Sbjct: 422 KKDSI-----DPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462


>AK223008-1|BAD96728.1|  502|Homo sapiens cytochrome P450, family 3,
           subfamily A, polypeptide 5 variant protein.
          Length = 502

 Score = 82.2 bits (194), Expect = 3e-15
 Identities = 53/166 (31%), Positives = 85/166 (51%), Gaps = 17/166 (10%)

Query: 274 LVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRACIKE 322
           + AG +TTS+ +S TLY +A + D QQKL++E+ +    ++           YL   + E
Sbjct: 303 IFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNE 362

Query: 323 AMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTN 382
            +R+ PV     R   K+  I G  IP+   +      L    KY+  P EF PER+ + 
Sbjct: 363 TLRLFPVAIRLERTCMKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF-SK 421

Query: 383 KSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
           K D +      P+  +PFG G R+CIG R A + ++  L ++++NF
Sbjct: 422 KKDSI-----DPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462


>AC005020-1|AAS02016.1|  502|Homo sapiens unknown protein.
          Length = 502

 Score = 82.2 bits (194), Expect = 3e-15
 Identities = 53/166 (31%), Positives = 85/166 (51%), Gaps = 17/166 (10%)

Query: 274 LVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRACIKE 322
           + AG +TTS+ +S TLY +A + D QQKL++E+ +    ++           YL   + E
Sbjct: 303 IFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNE 362

Query: 323 AMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTN 382
            +R+ PV     R   K+  I G  IP+   +      L    KY+  P EF PER+ + 
Sbjct: 363 TLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF-SK 421

Query: 383 KSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
           K D +      P+  +PFG G R+CIG R A + ++  L ++++NF
Sbjct: 422 KKDSI-----DPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462


>D00408-1|BAA00310.1|  503|Homo sapiens cytochrome P-450 HFLa
           protein.
          Length = 503

 Score = 81.8 bits (193), Expect = 5e-15
 Identities = 50/166 (30%), Positives = 84/166 (50%), Gaps = 16/166 (9%)

Query: 274 LVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRACIKE 322
           + AG +TTS+ +S  +Y +A + D QQK+++E+ +    ++           YL   + E
Sbjct: 303 IFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNE 362

Query: 323 AMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTN 382
            +R+ PV     R   K+  I G  IP+ V +      L    KY+  P +F+PER+   
Sbjct: 363 TLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKK 422

Query: 383 KSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
             D     N  P+  +PFG G R+CIG R A + ++  L ++++NF
Sbjct: 423 NKD-----NIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNF 463


>BC067436-1|AAH67436.1|  503|Homo sapiens cytochrome P450, family 3,
           subfamily A, polypeptide 7 protein.
          Length = 503

 Score = 81.8 bits (193), Expect = 5e-15
 Identities = 50/166 (30%), Positives = 84/166 (50%), Gaps = 16/166 (9%)

Query: 274 LVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRACIKE 322
           + AG +TTS+ +S  +Y +A + D QQK+++E+ +    ++           YL   + E
Sbjct: 303 IFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNE 362

Query: 323 AMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTN 382
            +R+ PV     R   K+  I G  IP+ V +      L    KY+  P +F+PER+   
Sbjct: 363 TLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKK 422

Query: 383 KSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
             D     N  P+  +PFG G R+CIG R A + ++  L ++++NF
Sbjct: 423 NKD-----NIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNF 463


>AF315325-1|AAG48618.1|  535|Homo sapiens cytochrome P450 variant
           3A7 protein.
          Length = 535

 Score = 81.8 bits (193), Expect = 5e-15
 Identities = 50/166 (30%), Positives = 84/166 (50%), Gaps = 16/166 (9%)

Query: 274 LVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRACIKE 322
           + AG +TTS+ +S  +Y +A + D QQK+++E+ +    ++           YL   + E
Sbjct: 303 IFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNE 362

Query: 323 AMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTN 382
            +R+ PV     R   K+  I G  IP+ V +      L    KY+  P +F+PER+   
Sbjct: 363 TLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKK 422

Query: 383 KSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
             D     N  P+  +PFG G R+CIG R A + ++  L ++++NF
Sbjct: 423 NKD-----NIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNF 463


>AF280107-3|AAG32289.1|  503|Homo sapiens cytochrome P450
           polypeptide 7 protein.
          Length = 503

 Score = 81.8 bits (193), Expect = 5e-15
 Identities = 50/166 (30%), Positives = 84/166 (50%), Gaps = 16/166 (9%)

Query: 274 LVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRACIKE 322
           + AG +TTS+ +S  +Y +A + D QQK+++E+ +    ++           YL   + E
Sbjct: 303 IFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNE 362

Query: 323 AMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTN 382
            +R+ PV     R   K+  I G  IP+ V +      L    KY+  P +F+PER+   
Sbjct: 363 TLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKK 422

Query: 383 KSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
             D     N  P+  +PFG G R+CIG R A + ++  L ++++NF
Sbjct: 423 NKD-----NIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNF 463


>AK054616-1|BAB70774.1|  465|Homo sapiens protein ( Homo sapiens
           cDNA FLJ30054 fis, clone ADRGL1000160, highly similar to
           CYTOCHROME P450 XXIB (EC 1.14.99.10). ).
          Length = 465

 Score = 77.8 bits (183), Expect = 7e-14
 Identities = 89/367 (24%), Positives = 170/367 (46%), Gaps = 42/367 (11%)

Query: 94  VSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQE 153
           + D+  LWK+ +      LL      +    +E++  +  ER+R+  D    I    ++E
Sbjct: 80  LGDYSLLWKAHKKLTRSALLLGIRDSM-EPVVEQLTQEFCERMRAQPDTPVAI----EEE 134

Query: 154 MNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNEL-DLKPSIWTYVS 212
            +L +   I  +  G+++   D NL   +  K + E +      S ++ D+ P +  +  
Sbjct: 135 FSLLTCSIICYLTFGDKIK--DDNLMP-AYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFP 190

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDI-------KMNKSKSDDEKPVLEKLL-DINEE 264
            P  R+  +  E+++++ +  + +  + +        M+       +P +E+    + E 
Sbjct: 191 NPGLRRLKQAIEKRDHIVEMQLGQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLQEG 250

Query: 265 YAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG------------- 311
           + ++ A D+L+ G +TT+NT+S     +  + + QQ+L+EE+  + G             
Sbjct: 251 HVHMAAVDLLIGGTETTANTLSWAAVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDR 310

Query: 312 -KRSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
            +   L A I E +R+ PVV   +  RTT+  +I GY IPE   I    Q   + E  + 
Sbjct: 311 ARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWE 370

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           RP EF P+R+L    +P    N+   A   FG G R C+G  +A LE+   L+++++ F 
Sbjct: 371 RPHEFWPDRFL----EP--GKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFT 421

Query: 430 VEWSGSS 436
           +  SG +
Sbjct: 422 LLPSGDA 428


>BC028102-1|AAH28102.1|  509|Homo sapiens cytochrome P450, family 4,
           subfamily X, polypeptide 1 protein.
          Length = 509

 Score = 77.4 bits (182), Expect = 1e-13
 Identities = 63/226 (27%), Positives = 105/226 (46%), Gaps = 26/226 (11%)

Query: 217 RKTMKMYEEQENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVA 276
           +K+++   +Q+N  K   +  LD +   K    DE       +D++ E      S  L+A
Sbjct: 266 KKSLQAGVKQDNTPKRKYQDFLDIVLSAK----DESGSSFSDIDVHSE-----VSTFLLA 316

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMS-----------KNGKRSYLRACIKEAMR 325
           G DT + ++S  LY +A+N + Q++ REEV             + G+ SY   CIKE  R
Sbjct: 317 GHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCR 376

Query: 326 ILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           ++P V    R  +K      G  +P  + +  +   L      +  P  F P R+    S
Sbjct: 377 LIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENS 436

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQV 430
           D       HP+A  PF  G R+CIG+  A +E++  ++ I+ +F+V
Sbjct: 437 D-----QRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRV 477


>AY358537-1|AAQ88901.1|  509|Homo sapiens EFSW1929 protein.
          Length = 509

 Score = 77.4 bits (182), Expect = 1e-13
 Identities = 63/226 (27%), Positives = 105/226 (46%), Gaps = 26/226 (11%)

Query: 217 RKTMKMYEEQENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVA 276
           +K+++   +Q+N  K   +  LD +   K    DE       +D++ E      S  L+A
Sbjct: 266 KKSLQAGVKQDNTPKRKYQDFLDIVLSAK----DESGSSFSDIDVHSE-----VSTFLLA 316

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMS-----------KNGKRSYLRACIKEAMR 325
           G DT + ++S  LY +A+N + Q++ REEV             + G+ SY   CIKE  R
Sbjct: 317 GHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCR 376

Query: 326 ILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           ++P V    R  +K      G  +P  + +  +   L      +  P  F P R+    S
Sbjct: 377 LIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENS 436

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQV 430
           D       HP+A  PF  G R+CIG+  A +E++  ++ I+ +F+V
Sbjct: 437 D-----QRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRV 477


>AM040940-1|CAJ13826.1|  509|Homo sapiens cytochrome P450 protein.
          Length = 509

 Score = 77.4 bits (182), Expect = 1e-13
 Identities = 63/226 (27%), Positives = 105/226 (46%), Gaps = 26/226 (11%)

Query: 217 RKTMKMYEEQENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVA 276
           +K+++   +Q+N  K   +  LD +   K    DE       +D++ E      S  L+A
Sbjct: 266 KKSLQAGVKQDNTPKRKYQDFLDIVLSAK----DESGSSFSDIDVHSE-----VSTFLLA 316

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMS-----------KNGKRSYLRACIKEAMR 325
           G DT + ++S  LY +A+N + Q++ REEV             + G+ SY   CIKE  R
Sbjct: 317 GHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCR 376

Query: 326 ILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           ++P V    R  +K      G  +P  + +  +   L      +  P  F P R+    S
Sbjct: 377 LIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENS 436

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQV 430
           D       HP+A  PF  G R+CIG+  A +E++  ++ I+ +F+V
Sbjct: 437 D-----QRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRV 477


>AL450996-1|CAH71035.1|  509|Homo sapiens cytochrome P450, family 4,
           subfamily X, polypeptide 1 protein.
          Length = 509

 Score = 77.4 bits (182), Expect = 1e-13
 Identities = 63/226 (27%), Positives = 105/226 (46%), Gaps = 26/226 (11%)

Query: 217 RKTMKMYEEQENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVA 276
           +K+++   +Q+N  K   +  LD +   K    DE       +D++ E      S  L+A
Sbjct: 266 KKSLQAGVKQDNTPKRKYQDFLDIVLSAK----DESGSSFSDIDVHSE-----VSTFLLA 316

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMS-----------KNGKRSYLRACIKEAMR 325
           G DT + ++S  LY +A+N + Q++ REEV             + G+ SY   CIKE  R
Sbjct: 317 GHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCR 376

Query: 326 ILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           ++P V    R  +K      G  +P  + +  +   L      +  P  F P R+    S
Sbjct: 377 LIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENS 436

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQV 430
           D       HP+A  PF  G R+CIG+  A +E++  ++ I+ +F+V
Sbjct: 437 D-----QRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRV 477


>AK131355-1|BAD18508.1|  508|Homo sapiens protein ( Homo sapiens
           cDNA FLJ16384 fis, clone TLIVE2007607, weakly  similar
           to CYTOCHROME P450 4A4 (EC 1.14.14.1). ).
          Length = 508

 Score = 77.4 bits (182), Expect = 1e-13
 Identities = 63/226 (27%), Positives = 105/226 (46%), Gaps = 26/226 (11%)

Query: 217 RKTMKMYEEQENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVA 276
           +K+++   +Q+N  K   +  LD +   K    DE       +D++ E      S  L+A
Sbjct: 265 KKSLQAGVKQDNTPKRKYQDFLDIVLSAK----DESGSSFSDIDVHSE-----VSTFLLA 315

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMS-----------KNGKRSYLRACIKEAMR 325
           G DT + ++S  LY +A+N + Q++ REEV             + G+ SY   CIKE  R
Sbjct: 316 GHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCR 375

Query: 326 ILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           ++P V    R  +K      G  +P  + +  +   L      +  P  F P R+    S
Sbjct: 376 LIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENS 435

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQV 430
           D       HP+A  PF  G R+CIG+  A +E++  ++ I+ +F+V
Sbjct: 436 D-----QRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRV 476


>AK098065-1|BAC05226.1|  509|Homo sapiens protein ( Homo sapiens
           cDNA FLJ40746 fis, clone TRACH2000359, weakly similar to
           CYTOCHROME P450 4A4 (EC 1.14.14.1). ).
          Length = 509

 Score = 77.4 bits (182), Expect = 1e-13
 Identities = 63/226 (27%), Positives = 105/226 (46%), Gaps = 26/226 (11%)

Query: 217 RKTMKMYEEQENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVA 276
           +K+++   +Q+N  K   +  LD +   K    DE       +D++ E      S  L+A
Sbjct: 266 KKSLQAGVKQDNTPKRKYQDFLDIVLSAK----DESGSSFSDIDVHSE-----VSTFLLA 316

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMS-----------KNGKRSYLRACIKEAMR 325
           G DT + ++S  LY +A+N + Q++ REEV             + G+ SY   CIKE  R
Sbjct: 317 GHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCR 376

Query: 326 ILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           ++P V    R  +K      G  +P  + +  +   L      +  P  F P R+    S
Sbjct: 377 LIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENS 436

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQV 430
           D       HP+A  PF  G R+CIG+  A +E++  ++ I+ +F+V
Sbjct: 437 D-----QRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRV 477


>AK091806-1|BAC03751.1|  444|Homo sapiens protein ( Homo sapiens
           cDNA FLJ34487 fis, clone HLUNG2004273, weakly similar to
           CYTOCHROME P450 4A4 (EC 1.14.14.1). ).
          Length = 444

 Score = 77.4 bits (182), Expect = 1e-13
 Identities = 63/226 (27%), Positives = 105/226 (46%), Gaps = 26/226 (11%)

Query: 217 RKTMKMYEEQENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVA 276
           +K+++   +Q+N  K   +  LD +   K    DE       +D++ E      S  L+A
Sbjct: 201 KKSLQAGVKQDNTPKRKYQDFLDIVLSAK----DESGSSFSDIDVHSE-----VSTFLLA 251

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMS-----------KNGKRSYLRACIKEAMR 325
           G DT + ++S  LY +A+N + Q++ REEV             + G+ SY   CIKE  R
Sbjct: 252 GHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCR 311

Query: 326 ILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           ++P V    R  +K      G  +P  + +  +   L      +  P  F P R+    S
Sbjct: 312 LIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENS 371

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQV 430
           D       HP+A  PF  G R+CIG+  A +E++  ++ I+ +F+V
Sbjct: 372 D-----QRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRV 412


>M28548-1|AAA52065.1|  495|Homo sapiens protein ( Human mutant
           21-hydroxylase B gene, complete cds. ).
          Length = 495

 Score = 77.0 bits (181), Expect = 1e-13
 Identities = 88/367 (23%), Positives = 171/367 (46%), Gaps = 42/367 (11%)

Query: 94  VSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQE 153
           + D+  LWK+ +      LL      +    +E++  +  ER+R+       I    ++E
Sbjct: 110 LGDYSLLWKAHKKLTRSALLLGIRDSM-EPVVEQLTQEFCERMRAQPGTPVAI----EEE 164

Query: 154 MNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNEL-DLKPSIWTYVS 212
            +L +   I  +  G+++   D NL   +  K + E +      S ++ D+ P +  +  
Sbjct: 165 FSLLTCSIICYLTFGDKIK--DDNLMP-AYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFP 220

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDI-------KMNKSKSDDEKPVLEKLL-DINEE 264
            P  R+  +  E+++++ +  +++  + +        M+       +P +E+    + E 
Sbjct: 221 NPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPTMEEGSGQLLEG 280

Query: 265 YAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG------------- 311
           + ++ A D+L+ G +TT+NT+S  +  +  + + QQ+L+EE+  + G             
Sbjct: 281 HVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDR 340

Query: 312 -KRSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
            +   L A I E +R+ PVV   +  RTT+  +I GY IPE   I    Q   + E  + 
Sbjct: 341 ARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWE 400

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           RP EF P+R+L    +P    N+   A   FG G R C+G  +A LE+   L+++++ F 
Sbjct: 401 RPHEFWPDRFL----EP--GKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFT 451

Query: 430 VEWSGSS 436
           +  SG +
Sbjct: 452 LLPSGDA 458


>X58906-1|CAA41709.1|  495|Homo sapiens steroid 21-monooxygenase
           protein.
          Length = 495

 Score = 76.6 bits (180), Expect = 2e-13
 Identities = 88/367 (23%), Positives = 171/367 (46%), Gaps = 42/367 (11%)

Query: 94  VSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQE 153
           + D+  LWK+ +      LL      +    +E++  +  ER+R+       I    ++E
Sbjct: 110 LGDYSLLWKAHKKLTRSALLLGIRDSM-EPVVEQLTQEFCERMRAQPGTPVAI----EEE 164

Query: 154 MNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNEL-DLKPSIWTYVS 212
            +L +   I  +  G+++   D NL   +  K + E +      S ++ D+ P +  +  
Sbjct: 165 FSLLTCSIICYLTFGDKIK--DDNLMP-AYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFP 220

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDI-------KMNKSKSDDEKPVLEKLL-DINEE 264
            P  R+  +  E+++++ +  +++  + +        M+       +P +E+    + E 
Sbjct: 221 NPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEG 280

Query: 265 YAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG------------- 311
           + ++ A D+L+ G +TT+NT+S  +  +  + + QQ+L+EE+  + G             
Sbjct: 281 HVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDH 340

Query: 312 -KRSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
            +   L A I E +R+ PVV   +  RTT+  +I GY IPE   I    Q   + E  + 
Sbjct: 341 ARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWE 400

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           RP EF P+R+L    +P    N+   A   FG G R C+G  +A LE+   L+++++ F 
Sbjct: 401 RPHEFWPDRFL----EP--GKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFT 451

Query: 430 VEWSGSS 436
           +  SG +
Sbjct: 452 LLSSGDA 458


>M24667-1|AAA52148.1|  256|Homo sapiens steroid 11-beta-hydroxylase
           protein.
          Length = 256

 Score = 76.6 bits (180), Expect = 2e-13
 Identities = 59/177 (33%), Positives = 85/177 (48%), Gaps = 19/177 (10%)

Query: 254 VLEKLLDINEEYAYIMASDM-LVAG-VDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG 311
           V E LL+       I A+ M L AG VD T   +  TL+ +A N + QQ LR+E ++   
Sbjct: 80  VAELLLNAELSPDAIKANCMELTAGSVDRTVFPLLMTLFELARNPNVQQPLRQESLAPAA 139

Query: 312 KRS-----------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQH 360
             S            LRA +KE +R+ PV     R  + +  +  YHIP    +      
Sbjct: 140 SISEHPQKATTELPLLRAALKETLRLYPVGLILERVVSSDLVLQNYHIPAGTLVRVFLYS 199

Query: 361 LSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEV 417
           L      +PRP  + P+RWL  K      G+   F + PFGFG+R C+GRR+AE ++
Sbjct: 200 LGRNPALFPRPERYNPQRWLDIK------GSGRNFYHVPFGFGMRQCLGRRLAEADM 250


>M26856-1|AAA52064.1|  495|Homo sapiens protein ( Human
           21-hydroxylase B gene, complete cds. ).
          Length = 495

 Score = 76.2 bits (179), Expect = 2e-13
 Identities = 88/367 (23%), Positives = 171/367 (46%), Gaps = 42/367 (11%)

Query: 94  VSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQE 153
           + D+  LWK+ +      LL      +    +E++  +  ER+R+       I    ++E
Sbjct: 110 LGDYSLLWKAHKKLTRSALLLGIRDSM-EPVVEQLTQEFCERMRAQPGTPVAI----EEE 164

Query: 154 MNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNEL-DLKPSIWTYVS 212
            +L +   I  +  G+++   D NL   +  K + E +      S ++ D+ P +  +  
Sbjct: 165 FSLLTCSIICYLTFGDKIK--DDNLMP-AYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFP 220

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDI-------KMNKSKSDDEKPVLEKLL-DINEE 264
            P  R+  +  E+++++ +  +++  + +        M+       +P +E+    + E 
Sbjct: 221 NPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEG 280

Query: 265 YAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG------------- 311
           + ++ A D+L+ G +TT+NT+S  +  +  + + QQ+L+EE+  + G             
Sbjct: 281 HVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDR 340

Query: 312 -KRSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
            +   L A I E +R+ PVV   +  RTT+  +I GY IPE   I    Q   + E  + 
Sbjct: 341 ARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWE 400

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           RP EF P+R+L    +P    N+   A   FG G R C+G  +A LE+   L+++++ F 
Sbjct: 401 RPHEFWPDRFL----EP--GKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFT 451

Query: 430 VEWSGSS 436
           +  SG +
Sbjct: 452 LLPSGDA 458


>M13936-1|AAA59695.1|  494|Homo sapiens CYP21P protein.
          Length = 494

 Score = 76.2 bits (179), Expect = 2e-13
 Identities = 88/367 (23%), Positives = 171/367 (46%), Gaps = 42/367 (11%)

Query: 94  VSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQE 153
           + D+  LWK+ +      LL      +    +E++  +  ER+R+       I    ++E
Sbjct: 109 LGDYSLLWKAHKKLTRSALLLGIRDSM-EPVVEQLTQEFCERMRAQPGTPVAI----EEE 163

Query: 154 MNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNEL-DLKPSIWTYVS 212
            +L +   I  +  G+++   D NL   +  K + E +      S ++ D+ P +  +  
Sbjct: 164 FSLLTCSIICYLTFGDKIK--DDNLMP-AYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFP 219

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDI-------KMNKSKSDDEKPVLEKLL-DINEE 264
            P  R+  +  E+++++ +  +++  + +        M+       +P +E+    + E 
Sbjct: 220 NPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEG 279

Query: 265 YAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG------------- 311
           + ++ A D+L+ G +TT+NT+S  +  +  + + QQ+L+EE+  + G             
Sbjct: 280 HVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDR 339

Query: 312 -KRSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
            +   L A I E +R+ PVV   +  RTT+  +I GY IPE   I    Q   + E  + 
Sbjct: 340 ARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWE 399

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           RP EF P+R+L    +P    N+   A   FG G R C+G  +A LE+   L+++++ F 
Sbjct: 400 RPHEFWPDRFL----EP--GKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFT 450

Query: 430 VEWSGSS 436
           +  SG +
Sbjct: 451 LLPSGDA 457


>BX679671-8|CAM26071.1|  464|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 464

 Score = 76.2 bits (179), Expect = 2e-13
 Identities = 88/367 (23%), Positives = 171/367 (46%), Gaps = 42/367 (11%)

Query: 94  VSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQE 153
           + D+  LWK+ +      LL      +    +E++  +  ER+R+       I    ++E
Sbjct: 79  LGDYSLLWKAHKKLTRSALLLGIRDSM-EPVVEQLTQEFCERMRAQPGTPVAI----EEE 133

Query: 154 MNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNEL-DLKPSIWTYVS 212
            +L +   I  +  G+++   D NL   +  K + E +      S ++ D+ P +  +  
Sbjct: 134 FSLLTCSIICYLTFGDKIK--DDNLMP-AYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFP 189

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDI-------KMNKSKSDDEKPVLEKLL-DINEE 264
            P  R+  +  E+++++ +  +++  + +        M+       +P +E+    + E 
Sbjct: 190 NPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEG 249

Query: 265 YAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG------------- 311
           + ++ A D+L+ G +TT+NT+S  +  +  + + QQ+L+EE+  + G             
Sbjct: 250 HVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDR 309

Query: 312 -KRSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
            +   L A I E +R+ PVV   +  RTT+  +I GY IPE   I    Q   + E  + 
Sbjct: 310 ARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWE 369

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           RP EF P+R+L    +P    N+   A   FG G R C+G  +A LE+   L+++++ F 
Sbjct: 370 RPHEFWPDRFL----EP--GKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFT 420

Query: 430 VEWSGSS 436
           +  SG +
Sbjct: 421 LLPSGDA 427


>BX679671-7|CAM26070.1|  494|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 494

 Score = 76.2 bits (179), Expect = 2e-13
 Identities = 88/367 (23%), Positives = 171/367 (46%), Gaps = 42/367 (11%)

Query: 94  VSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQE 153
           + D+  LWK+ +      LL      +    +E++  +  ER+R+       I    ++E
Sbjct: 109 LGDYSLLWKAHKKLTRSALLLGIRDSM-EPVVEQLTQEFCERMRAQPGTPVAI----EEE 163

Query: 154 MNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNEL-DLKPSIWTYVS 212
            +L +   I  +  G+++   D NL   +  K + E +      S ++ D+ P +  +  
Sbjct: 164 FSLLTCSIICYLTFGDKIK--DDNLMP-AYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFP 219

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDI-------KMNKSKSDDEKPVLEKLL-DINEE 264
            P  R+  +  E+++++ +  +++  + +        M+       +P +E+    + E 
Sbjct: 220 NPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEG 279

Query: 265 YAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG------------- 311
           + ++ A D+L+ G +TT+NT+S  +  +  + + QQ+L+EE+  + G             
Sbjct: 280 HVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDR 339

Query: 312 -KRSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
            +   L A I E +R+ PVV   +  RTT+  +I GY IPE   I    Q   + E  + 
Sbjct: 340 ARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWE 399

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           RP EF P+R+L    +P    N+   A   FG G R C+G  +A LE+   L+++++ F 
Sbjct: 400 RPHEFWPDRFL----EP--GKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFT 450

Query: 430 VEWSGSS 436
           +  SG +
Sbjct: 451 LLPSGDA 457


>BC125182-1|AAI25183.1|  494|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 494

 Score = 76.2 bits (179), Expect = 2e-13
 Identities = 88/367 (23%), Positives = 171/367 (46%), Gaps = 42/367 (11%)

Query: 94  VSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQE 153
           + D+  LWK+ +      LL      +    +E++  +  ER+R+       I    ++E
Sbjct: 109 LGDYSLLWKAHKKLTRSALLLGIRDSM-EPVVEQLTQEFCERMRAQPGTPVAI----EEE 163

Query: 154 MNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNEL-DLKPSIWTYVS 212
            +L +   I  +  G+++   D NL   +  K + E +      S ++ D+ P +  +  
Sbjct: 164 FSLLTCSIICYLTFGDKIK--DDNLMP-AYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFP 219

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDI-------KMNKSKSDDEKPVLEKLL-DINEE 264
            P  R+  +  E+++++ +  +++  + +        M+       +P +E+    + E 
Sbjct: 220 NPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEG 279

Query: 265 YAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG------------- 311
           + ++ A D+L+ G +TT+NT+S  +  +  + + QQ+L+EE+  + G             
Sbjct: 280 HVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDR 339

Query: 312 -KRSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
            +   L A I E +R+ PVV   +  RTT+  +I GY IPE   I    Q   + E  + 
Sbjct: 340 ARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWE 399

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           RP EF P+R+L    +P    N+   A   FG G R C+G  +A LE+   L+++++ F 
Sbjct: 400 RPHEFWPDRFL----EP--GKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFT 450

Query: 430 VEWSGSS 436
           +  SG +
Sbjct: 451 LLPSGDA 457


>BC125181-1|AAI25182.1|  495|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 495

 Score = 76.2 bits (179), Expect = 2e-13
 Identities = 88/367 (23%), Positives = 171/367 (46%), Gaps = 42/367 (11%)

Query: 94  VSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQE 153
           + D+  LWK+ +      LL      +    +E++  +  ER+R+       I    ++E
Sbjct: 110 LGDYSLLWKAHKKLTRSALLLGIRDSM-EPVVEQLTQEFCERMRAQPGTPVAI----EEE 164

Query: 154 MNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNEL-DLKPSIWTYVS 212
            +L +   I  +  G+++   D NL   +  K + E +      S ++ D+ P +  +  
Sbjct: 165 FSLLTCSIICYLTFGDKIK--DDNLMP-AYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFP 220

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDI-------KMNKSKSDDEKPVLEKLL-DINEE 264
            P  R+  +  E+++++ +  +++  + +        M+       +P +E+    + E 
Sbjct: 221 NPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEG 280

Query: 265 YAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG------------- 311
           + ++ A D+L+ G +TT+NT+S  +  +  + + QQ+L+EE+  + G             
Sbjct: 281 HVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDR 340

Query: 312 -KRSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
            +   L A I E +R+ PVV   +  RTT+  +I GY IPE   I    Q   + E  + 
Sbjct: 341 ARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWE 400

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           RP EF P+R+L    +P    N+   A   FG G R C+G  +A LE+   L+++++ F 
Sbjct: 401 RPHEFWPDRFL----EP--GKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFT 451

Query: 430 VEWSGSS 436
           +  SG +
Sbjct: 452 LLPSGDA 458


>AY390424-1|AAQ92352.1|  503|Homo sapiens cytochrome P450 CYP3A43.3
           protein.
          Length = 503

 Score = 76.2 bits (179), Expect = 2e-13
 Identities = 50/167 (29%), Positives = 80/167 (47%), Gaps = 16/167 (9%)

Query: 273 MLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRACIK 321
           ++ A  DTTS T+   +Y +A + D QQKL+EE+ +    ++           YL   + 
Sbjct: 302 IIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLANKAPVTYDALVQMEYLDMVVN 361

Query: 322 EAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLT 381
           E +R+ PVVS   R   K+  I G  IP+ + +      L    KY+  P +F PER+  
Sbjct: 362 ETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSK 421

Query: 382 NKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
              D +       +   PFG G R+CIG R A   ++  + + ++NF
Sbjct: 422 KNKDSI-----DLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNF 463


>AM183951-1|CAJ75805.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 76.2 bits (179), Expect = 2e-13
 Identities = 88/367 (23%), Positives = 171/367 (46%), Gaps = 42/367 (11%)

Query: 94  VSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQE 153
           + D+  LWK+ +      LL      +    +E++  +  ER+R+       I    ++E
Sbjct: 109 LGDYSLLWKAHKKLTRSALLLGIRDSM-EPVVEQLTQEFCERMRAQPGTPVAI----EEE 163

Query: 154 MNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNEL-DLKPSIWTYVS 212
            +L +   I  +  G+++   D NL   +  K + E +      S ++ D+ P +  +  
Sbjct: 164 FSLLTCSIICYLTFGDKIK--DDNLMP-AYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFP 219

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDI-------KMNKSKSDDEKPVLEKLL-DINEE 264
            P  R+  +  E+++++ +  +++  + +        M+       +P +E+    + E 
Sbjct: 220 NPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEG 279

Query: 265 YAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG------------- 311
           + ++ A D+L+ G +TT+NT+S  +  +  + + QQ+L+EE+  + G             
Sbjct: 280 HVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDR 339

Query: 312 -KRSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
            +   L A I E +R+ PVV   +  RTT+  +I GY IPE   I    Q   + E  + 
Sbjct: 340 ARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWE 399

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           RP EF P+R+L    +P    N+   A   FG G R C+G  +A LE+   L+++++ F 
Sbjct: 400 RPHEFWPDRFL----EP--GKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFT 450

Query: 430 VEWSGSS 436
           +  SG +
Sbjct: 451 LLPSGDA 457


>AM183945-1|CAJ75799.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 76.2 bits (179), Expect = 2e-13
 Identities = 92/368 (25%), Positives = 172/368 (46%), Gaps = 44/368 (11%)

Query: 94  VSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVAT-DMVERLRSLRDENNRIRGQFDQ 152
           + D+  LWK+ +      LL    IR     +EE  T +  ER+R+       I    ++
Sbjct: 109 LGDYSLLWKAHKKLTRSALLLG--IRDSMEPVEEQLTQEFCERMRAQPGTPVAI----EE 162

Query: 153 EMNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNEL-DLKPSIWTYV 211
           E +L +   I  +  G+++   D NL   +  K + E +      S ++ D+ P +  + 
Sbjct: 163 EFSLLTCSIICYLTFGDKIK--DDNLMP-AYYKCIQEVLKTWSHWSIQIVDVIPFL-RFF 218

Query: 212 STPLFRKTMKMYEEQENLTKYFIKKALDDI-------KMNKSKSDDEKPVLEKLL-DINE 263
             P  R+  +  E+++++ +  +++  + +        M+       +P +E+    + E
Sbjct: 219 PNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLE 278

Query: 264 EYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG------------ 311
            + ++ A D+L+ G +TT+NT+S  +  +  + + QQ+L+EE+  + G            
Sbjct: 279 GHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKD 338

Query: 312 --KRSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYY 368
             +   L A I E +R+ PVV   +  RTT+  +I GY IPE   I    Q   + E  +
Sbjct: 339 RARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVW 398

Query: 369 PRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
            RP EF P+R+L    +P    N+   A   FG G R C+G  +A LE+   L+++++ F
Sbjct: 399 ERPHEFWPDRFL----EP--GKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAF 449

Query: 429 QVEWSGSS 436
            +  SG +
Sbjct: 450 TLLPSGDA 457


>AM086565-1|CAJ31104.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 76.2 bits (179), Expect = 2e-13
 Identities = 88/367 (23%), Positives = 171/367 (46%), Gaps = 42/367 (11%)

Query: 94  VSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQE 153
           + D+  LWK+ +      LL      +    +E++  +  ER+R+       I    ++E
Sbjct: 109 LGDYSLLWKAHKKLTRSALLLGIRDSM-EPVVEQLTQEFCERMRAQPGTPVAI----EEE 163

Query: 154 MNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNEL-DLKPSIWTYVS 212
            +L +   I  +  G+++   D NL   +  K + E +      S ++ D+ P +  +  
Sbjct: 164 FSLLTCSIICYLTFGDKIK--DDNLMP-AYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFP 219

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDI-------KMNKSKSDDEKPVLEKLL-DINEE 264
            P  R+  +  E+++++ +  +++  + +        M+       +P +E+    + E 
Sbjct: 220 NPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEG 279

Query: 265 YAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG------------- 311
           + ++ A D+L+ G +TT+NT+S  +  +  + + QQ+L+EE+  + G             
Sbjct: 280 HVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDR 339

Query: 312 -KRSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
            +   L A I E +R+ PVV   +  RTT+  +I GY IPE   I    Q   + E  + 
Sbjct: 340 ARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGTHLDETVWE 399

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           RP EF P+R+L    +P    N+   A   FG G R C+G  +A LE+   L+++++ F 
Sbjct: 400 RPHEFWPDRFL----EP--GKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFT 450

Query: 430 VEWSGSS 436
           +  SG +
Sbjct: 451 LLPSGDA 457


>AL929593-2|CAI41778.1|  465|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 465

 Score = 76.2 bits (179), Expect = 2e-13
 Identities = 88/367 (23%), Positives = 171/367 (46%), Gaps = 42/367 (11%)

Query: 94  VSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQE 153
           + D+  LWK+ +      LL      +    +E++  +  ER+R+       I    ++E
Sbjct: 80  LGDYSLLWKAHKKLTRSALLLGIRDSM-EPVVEQLTQEFCERMRAQPGTPVAI----EEE 134

Query: 154 MNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNEL-DLKPSIWTYVS 212
            +L +   I  +  G+++   D NL   +  K + E +      S ++ D+ P +  +  
Sbjct: 135 FSLLTCSIICYLTFGDKIK--DDNLMP-AYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFP 190

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDI-------KMNKSKSDDEKPVLEKLL-DINEE 264
            P  R+  +  E+++++ +  +++  + +        M+       +P +E+    + E 
Sbjct: 191 NPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEG 250

Query: 265 YAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG------------- 311
           + ++ A D+L+ G +TT+NT+S  +  +  + + QQ+L+EE+  + G             
Sbjct: 251 HVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDR 310

Query: 312 -KRSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
            +   L A I E +R+ PVV   +  RTT+  +I GY IPE   I    Q   + E  + 
Sbjct: 311 ARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWE 370

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           RP EF P+R+L    +P    N+   A   FG G R C+G  +A LE+   L+++++ F 
Sbjct: 371 RPHEFWPDRFL----EP--GKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFT 421

Query: 430 VEWSGSS 436
           +  SG +
Sbjct: 422 LLPSGDA 428


>AL929593-1|CAI41779.1|  495|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 495

 Score = 76.2 bits (179), Expect = 2e-13
 Identities = 88/367 (23%), Positives = 171/367 (46%), Gaps = 42/367 (11%)

Query: 94  VSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQE 153
           + D+  LWK+ +      LL      +    +E++  +  ER+R+       I    ++E
Sbjct: 110 LGDYSLLWKAHKKLTRSALLLGIRDSM-EPVVEQLTQEFCERMRAQPGTPVAI----EEE 164

Query: 154 MNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNEL-DLKPSIWTYVS 212
            +L +   I  +  G+++   D NL   +  K + E +      S ++ D+ P +  +  
Sbjct: 165 FSLLTCSIICYLTFGDKIK--DDNLMP-AYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFP 220

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDI-------KMNKSKSDDEKPVLEKLL-DINEE 264
            P  R+  +  E+++++ +  +++  + +        M+       +P +E+    + E 
Sbjct: 221 NPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEG 280

Query: 265 YAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG------------- 311
           + ++ A D+L+ G +TT+NT+S  +  +  + + QQ+L+EE+  + G             
Sbjct: 281 HVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDR 340

Query: 312 -KRSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
            +   L A I E +R+ PVV   +  RTT+  +I GY IPE   I    Q   + E  + 
Sbjct: 341 ARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWE 400

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           RP EF P+R+L    +P    N+   A   FG G R C+G  +A LE+   L+++++ F 
Sbjct: 401 RPHEFWPDRFL----EP--GKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFT 451

Query: 430 VEWSGSS 436
           +  SG +
Sbjct: 452 LLPSGDA 458


>AL662849-19|CAI17480.1|  465|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 465

 Score = 76.2 bits (179), Expect = 2e-13
 Identities = 88/367 (23%), Positives = 171/367 (46%), Gaps = 42/367 (11%)

Query: 94  VSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQE 153
           + D+  LWK+ +      LL      +    +E++  +  ER+R+       I    ++E
Sbjct: 80  LGDYSLLWKAHKKLTRSALLLGIRDSM-EPVVEQLTQEFCERMRAQPGTPVAI----EEE 134

Query: 154 MNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNEL-DLKPSIWTYVS 212
            +L +   I  +  G+++   D NL   +  K + E +      S ++ D+ P +  +  
Sbjct: 135 FSLLTCSIICYLTFGDKIK--DDNLMP-AYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFP 190

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDI-------KMNKSKSDDEKPVLEKLL-DINEE 264
            P  R+  +  E+++++ +  +++  + +        M+       +P +E+    + E 
Sbjct: 191 NPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEG 250

Query: 265 YAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG------------- 311
           + ++ A D+L+ G +TT+NT+S  +  +  + + QQ+L+EE+  + G             
Sbjct: 251 HVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDR 310

Query: 312 -KRSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
            +   L A I E +R+ PVV   +  RTT+  +I GY IPE   I    Q   + E  + 
Sbjct: 311 ARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWE 370

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           RP EF P+R+L    +P    N+   A   FG G R C+G  +A LE+   L+++++ F 
Sbjct: 371 RPHEFWPDRFL----EP--GKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFT 421

Query: 430 VEWSGSS 436
           +  SG +
Sbjct: 422 LLPSGDA 428


>AL662849-18|CAI17479.1|  495|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 495

 Score = 76.2 bits (179), Expect = 2e-13
 Identities = 88/367 (23%), Positives = 171/367 (46%), Gaps = 42/367 (11%)

Query: 94  VSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQE 153
           + D+  LWK+ +      LL      +    +E++  +  ER+R+       I    ++E
Sbjct: 110 LGDYSLLWKAHKKLTRSALLLGIRDSM-EPVVEQLTQEFCERMRAQPGTPVAI----EEE 164

Query: 154 MNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNEL-DLKPSIWTYVS 212
            +L +   I  +  G+++   D NL   +  K + E +      S ++ D+ P +  +  
Sbjct: 165 FSLLTCSIICYLTFGDKIK--DDNLMP-AYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFP 220

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDI-------KMNKSKSDDEKPVLEKLL-DINEE 264
            P  R+  +  E+++++ +  +++  + +        M+       +P +E+    + E 
Sbjct: 221 NPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEG 280

Query: 265 YAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG------------- 311
           + ++ A D+L+ G +TT+NT+S  +  +  + + QQ+L+EE+  + G             
Sbjct: 281 HVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDR 340

Query: 312 -KRSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
            +   L A I E +R+ PVV   +  RTT+  +I GY IPE   I    Q   + E  + 
Sbjct: 341 ARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWE 400

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           RP EF P+R+L    +P    N+   A   FG G R C+G  +A LE+   L+++++ F 
Sbjct: 401 RPHEFWPDRFL----EP--GKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFT 451

Query: 430 VEWSGSS 436
           +  SG +
Sbjct: 452 LLPSGDA 458


>AL645922-24|CAI41754.1|  495|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 495

 Score = 76.2 bits (179), Expect = 2e-13
 Identities = 88/367 (23%), Positives = 171/367 (46%), Gaps = 42/367 (11%)

Query: 94  VSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQE 153
           + D+  LWK+ +      LL      +    +E++  +  ER+R+       I    ++E
Sbjct: 110 LGDYSLLWKAHKKLTRSALLLGIRDSM-EPVVEQLTQEFCERMRAQPGTPVAI----EEE 164

Query: 154 MNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNEL-DLKPSIWTYVS 212
            +L +   I  +  G+++   D NL   +  K + E +      S ++ D+ P +  +  
Sbjct: 165 FSLLTCSIICYLTFGDKIK--DDNLMP-AYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFP 220

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDI-------KMNKSKSDDEKPVLEKLL-DINEE 264
            P  R+  +  E+++++ +  +++  + +        M+       +P +E+    + E 
Sbjct: 221 NPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEG 280

Query: 265 YAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG------------- 311
           + ++ A D+L+ G +TT+NT+S  +  +  + + QQ+L+EE+  + G             
Sbjct: 281 HVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDR 340

Query: 312 -KRSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
            +   L A I E +R+ PVV   +  RTT+  +I GY IPE   I    Q   + E  + 
Sbjct: 341 ARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWE 400

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           RP EF P+R+L    +P    N+   A   FG G R C+G  +A LE+   L+++++ F 
Sbjct: 401 RPHEFWPDRFL----EP--GKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFT 451

Query: 430 VEWSGSS 436
           +  SG +
Sbjct: 452 LLPSGDA 458


>AL645922-23|CAI41755.1|  465|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 465

 Score = 76.2 bits (179), Expect = 2e-13
 Identities = 88/367 (23%), Positives = 171/367 (46%), Gaps = 42/367 (11%)

Query: 94  VSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQE 153
           + D+  LWK+ +      LL      +    +E++  +  ER+R+       I    ++E
Sbjct: 80  LGDYSLLWKAHKKLTRSALLLGIRDSM-EPVVEQLTQEFCERMRAQPGTPVAI----EEE 134

Query: 154 MNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNEL-DLKPSIWTYVS 212
            +L +   I  +  G+++   D NL   +  K + E +      S ++ D+ P +  +  
Sbjct: 135 FSLLTCSIICYLTFGDKIK--DDNLMP-AYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFP 190

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDI-------KMNKSKSDDEKPVLEKLL-DINEE 264
            P  R+  +  E+++++ +  +++  + +        M+       +P +E+    + E 
Sbjct: 191 NPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEG 250

Query: 265 YAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG------------- 311
           + ++ A D+L+ G +TT+NT+S  +  +  + + QQ+L+EE+  + G             
Sbjct: 251 HVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDR 310

Query: 312 -KRSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
            +   L A I E +R+ PVV   +  RTT+  +I GY IPE   I    Q   + E  + 
Sbjct: 311 ARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWE 370

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           RP EF P+R+L    +P    N+   A   FG G R C+G  +A LE+   L+++++ F 
Sbjct: 371 RPHEFWPDRFL----EP--GKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFT 421

Query: 430 VEWSGSS 436
           +  SG +
Sbjct: 422 LLPSGDA 428


>AL049547-7|CAB89301.1|  495|Homo sapiens dJ34F7.3 (cytochrome P450,
           subfamily XXIA (steroid 21-hydroxylase, congenital a
           protein.
          Length = 495

 Score = 76.2 bits (179), Expect = 2e-13
 Identities = 88/367 (23%), Positives = 171/367 (46%), Gaps = 42/367 (11%)

Query: 94  VSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQE 153
           + D+  LWK+ +      LL      +    +E++  +  ER+R+       I    ++E
Sbjct: 110 LGDYSLLWKAHKKLTRSALLLGIRDSM-EPVVEQLTQEFCERMRAQPGTPVAI----EEE 164

Query: 154 MNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNEL-DLKPSIWTYVS 212
            +L +   I  +  G+++   D NL   +  K + E +      S ++ D+ P +  +  
Sbjct: 165 FSLLTCSIICYLTFGDKIK--DDNLMP-AYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFP 220

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDI-------KMNKSKSDDEKPVLEKLL-DINEE 264
            P  R+  +  E+++++ +  +++  + +        M+       +P +E+    + E 
Sbjct: 221 NPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEG 280

Query: 265 YAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG------------- 311
           + ++ A D+L+ G +TT+NT+S  +  +  + + QQ+L+EE+  + G             
Sbjct: 281 HVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDR 340

Query: 312 -KRSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
            +   L A I E +R+ PVV   +  RTT+  +I GY IPE   I    Q   + E  + 
Sbjct: 341 ARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWE 400

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           RP EF P+R+L    +P    N+   A   FG G R C+G  +A LE+   L+++++ F 
Sbjct: 401 RPHEFWPDRFL----EP--GKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFT 451

Query: 430 VEWSGSS 436
           +  SG +
Sbjct: 452 LLPSGDA 458


>AF077974-1|AAD45405.1|  403|Homo sapiens cytochrome P450
           21-hydroxylase protein.
          Length = 403

 Score = 76.2 bits (179), Expect = 2e-13
 Identities = 88/367 (23%), Positives = 171/367 (46%), Gaps = 42/367 (11%)

Query: 94  VSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQE 153
           + D+  LWK+ +      LL      +    +E++  +  ER+R+       I    ++E
Sbjct: 18  LGDYSLLWKAHKKLTRSALLLGIRDSM-EPVVEQLTQEFCERMRAQPGTPVAI----EEE 72

Query: 154 MNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNEL-DLKPSIWTYVS 212
            +L +   I  +  G+++   D NL   +  K + E +      S ++ D+ P +  +  
Sbjct: 73  FSLLTCSIICYLTFGDKIK--DDNLMP-AYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFP 128

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDI-------KMNKSKSDDEKPVLEKLL-DINEE 264
            P  R+  +  E+++++ +  +++  + +        M+       +P +E+    + E 
Sbjct: 129 NPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEG 188

Query: 265 YAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG------------- 311
           + ++ A D+L+ G +TT+NT+S  +  +  + + QQ+L+EE+  + G             
Sbjct: 189 HVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDR 248

Query: 312 -KRSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
            +   L A I E +R+ PVV   +  RTT+  +I GY IPE   I    Q   + E  + 
Sbjct: 249 ARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWE 308

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           RP EF P+R+L    +P    N+   A   FG G R C+G  +A LE+   L+++++ F 
Sbjct: 309 RPHEFWPDRFL----EP--GKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFT 359

Query: 430 VEWSGSS 436
           +  SG +
Sbjct: 360 LLPSGDA 366


>AF019413-2|AAB67982.1|  495|Homo sapiens cytochrome P450
           21-hydroxylase protein.
          Length = 495

 Score = 76.2 bits (179), Expect = 2e-13
 Identities = 88/367 (23%), Positives = 171/367 (46%), Gaps = 42/367 (11%)

Query: 94  VSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQE 153
           + D+  LWK+ +      LL      +    +E++  +  ER+R+       I    ++E
Sbjct: 110 LGDYSLLWKAHKKLTRSALLLGIRDSM-EPVVEQLTQEFCERMRAQPGTPVAI----EEE 164

Query: 154 MNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNEL-DLKPSIWTYVS 212
            +L +   I  +  G+++   D NL   +  K + E +      S ++ D+ P +  +  
Sbjct: 165 FSLLTCSIICYLTFGDKIK--DDNLMP-AYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFP 220

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDI-------KMNKSKSDDEKPVLEKLL-DINEE 264
            P  R+  +  E+++++ +  +++  + +        M+       +P +E+    + E 
Sbjct: 221 NPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEG 280

Query: 265 YAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG------------- 311
           + ++ A D+L+ G +TT+NT+S  +  +  + + QQ+L+EE+  + G             
Sbjct: 281 HVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDR 340

Query: 312 -KRSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
            +   L A I E +R+ PVV   +  RTT+  +I GY IPE   I    Q   + E  + 
Sbjct: 341 ARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWE 400

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           RP EF P+R+L    +P    N+   A   FG G R C+G  +A LE+   L+++++ F 
Sbjct: 401 RPHEFWPDRFL----EP--GKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFT 451

Query: 430 VEWSGSS 436
           +  SG +
Sbjct: 452 LLPSGDA 458


>M21550-1|AAA52063.1|  495|Homo sapiens CYP21 protein.
          Length = 495

 Score = 75.8 bits (178), Expect = 3e-13
 Identities = 88/367 (23%), Positives = 171/367 (46%), Gaps = 42/367 (11%)

Query: 94  VSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQE 153
           + D+  LWK+ +      LL      +    +E++  +  ER+R+       I    ++E
Sbjct: 110 LGDYSLLWKAHKKLTRSALLLGIRDSM-EPVVEQLTQEFCERMRAQPGTPVAI----EEE 164

Query: 154 MNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNEL-DLKPSIWTYVS 212
            +L +   I  +  G+++   D NL   +  K + E +      S ++ D+ P +  +  
Sbjct: 165 FSLLTCSIICYLTFGDKIK--DDNLMP-AYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFP 220

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDI-------KMNKSKSDDEKPVLEKLL-DINEE 264
            P  R+  +  E+++++ +  +++  + +        M+       +P +E+    + E 
Sbjct: 221 NPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEG 280

Query: 265 YAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG------------- 311
           + ++ A D+L+ G +TT+NT+S  +  +  + + QQ+L+EE+  + G             
Sbjct: 281 HLHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDR 340

Query: 312 -KRSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
            +   L A I E +R+ PVV   +  RTT+  +I GY IPE   I    Q   + E  + 
Sbjct: 341 ARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWE 400

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           RP EF P+R+L    +P    N+   A   FG G R C+G  +A LE+   L+++++ F 
Sbjct: 401 RPHEFWPDRFL----EP--GKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFT 451

Query: 430 VEWSGSS 436
           +  SG +
Sbjct: 452 LLPSGDA 458


>AM183949-1|CAJ75803.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 75.8 bits (178), Expect = 3e-13
 Identities = 88/367 (23%), Positives = 171/367 (46%), Gaps = 42/367 (11%)

Query: 94  VSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQE 153
           + D+  LWK+ +      LL      +    +E++  +  ER+R+       I    ++E
Sbjct: 109 LGDYSLLWKAHKKLTRSALLLGIRDSM-EPVVEQLTQEFCERMRAQPGTPVAI----EEE 163

Query: 154 MNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNEL-DLKPSIWTYVS 212
            +L +   I  +  G+++   D NL   +  K + E +      S ++ D+ P +  +  
Sbjct: 164 FSLLTCSIICYLTFGDKIK--DDNLMP-AYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFP 219

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDI-------KMNKSKSDDEKPVLEKLL-DINEE 264
            P  R+  +  E+++++ +  +++  + +        M+       +P +E+    + E 
Sbjct: 220 NPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEG 279

Query: 265 YAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG------------- 311
           + ++ A D+L+ G +TT+NT+S  +  +  + + QQ+L+EE+  + G             
Sbjct: 280 HVHMAAVDLLIGGTETTANTLSWAVVFLFHHPEIQQRLQEELDHELGPGASSSRVPYKDR 339

Query: 312 -KRSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
            +   L A I E +R+ PVV   +  RTT+  +I GY IPE   I    Q   + E  + 
Sbjct: 340 ARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWE 399

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           RP EF P+R+L    +P    N+   A   FG G R C+G  +A LE+   L+++++ F 
Sbjct: 400 RPHEFWPDRFL----EP--GKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFT 450

Query: 430 VEWSGSS 436
           +  SG +
Sbjct: 451 LLPSGDA 457


>AM183946-1|CAJ75800.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 75.8 bits (178), Expect = 3e-13
 Identities = 88/367 (23%), Positives = 168/367 (45%), Gaps = 42/367 (11%)

Query: 94  VSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQE 153
           + D+  LWK+ +      LL    IR    ++E V   + +  R             ++E
Sbjct: 109 LGDYSLLWKAHKKLTRSALLLG--IR---DSMEPVVEQLTQEFRERMRAQPGTPVAIEEE 163

Query: 154 MNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNEL-DLKPSIWTYVS 212
            +L +   I  +  G+++   D NL   +  K + E +      S ++ D+ P +  +  
Sbjct: 164 FSLLTCSIICYLTFGDKIK--DDNLMP-AYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFP 219

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDI-------KMNKSKSDDEKPVLEKLL-DINEE 264
            P  R+  +  E+++++ +  +++  + +        M+       +P +E+    + E 
Sbjct: 220 NPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEG 279

Query: 265 YAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG------------- 311
           + ++ A D+L+ G +TT+NT+S  +  +  + + QQ+L+EE+  + G             
Sbjct: 280 HVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDR 339

Query: 312 -KRSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
            +   L A I E +R+ PVV   +  RTT+  +I GY IPE   I    Q   + E  + 
Sbjct: 340 ARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWE 399

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           RP EF P+R+L    +P    N+   A   FG G R C+G  +A LE+   L+++++ F 
Sbjct: 400 RPHEFWPDRFL----EP--GKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFT 450

Query: 430 VEWSGSS 436
           +  SG +
Sbjct: 451 LLPSGDA 457


>BC100981-1|AAI00982.1|  393|Homo sapiens CYP3A43 protein protein.
          Length = 393

 Score = 75.4 bits (177), Expect = 4e-13
 Identities = 50/167 (29%), Positives = 80/167 (47%), Gaps = 16/167 (9%)

Query: 273 MLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRACIK 321
           ++ A  DTTS T+   +Y +A + D QQKL+EE+ +    ++           YL   + 
Sbjct: 192 IIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVN 251

Query: 322 EAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLT 381
           E +R+ PVVS   R   K+  I G  IP+ + +      L    KY+  P +F PER+  
Sbjct: 252 ETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSK 311

Query: 382 NKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
              D +       +   PFG G R+CIG R A   ++  + + ++NF
Sbjct: 312 KNKDSI-----DLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNF 353


>AY390425-1|AAQ92353.1|  503|Homo sapiens cytochrome P450 CYP3A43.1
           protein.
          Length = 503

 Score = 75.4 bits (177), Expect = 4e-13
 Identities = 50/167 (29%), Positives = 80/167 (47%), Gaps = 16/167 (9%)

Query: 273 MLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRACIK 321
           ++ A  DTTS T+   +Y +A + D QQKL+EE+ +    ++           YL   + 
Sbjct: 302 IIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVN 361

Query: 322 EAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLT 381
           E +R+ PVVS   R   K+  I G  IP+ + +      L    KY+  P +F PER+  
Sbjct: 362 ETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSK 421

Query: 382 NKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
              D +       +   PFG G R+CIG R A   ++  + + ++NF
Sbjct: 422 KNKDSI-----DLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNF 463


>AF337813-1|AAK38841.1|  503|Homo sapiens cytochrome P450 subfamily
           IIIA polypeptide 43 protein.
          Length = 503

 Score = 75.4 bits (177), Expect = 4e-13
 Identities = 50/167 (29%), Positives = 80/167 (47%), Gaps = 16/167 (9%)

Query: 273 MLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRACIK 321
           ++ A  DTTS T+   +Y +A + D QQKL+EE+ +    ++           YL   + 
Sbjct: 302 IIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVN 361

Query: 322 EAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLT 381
           E +R+ PVVS   R   K+  I G  IP+ + +      L    KY+  P +F PER+  
Sbjct: 362 ETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSK 421

Query: 382 NKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
              D +       +   PFG G R+CIG R A   ++  + + ++NF
Sbjct: 422 KNKDSI-----DLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNF 463


>AF319634-1|AAK00325.1|  503|Homo sapiens cytochrome P450 CYP3A43
           protein.
          Length = 503

 Score = 75.4 bits (177), Expect = 4e-13
 Identities = 50/167 (29%), Positives = 80/167 (47%), Gaps = 16/167 (9%)

Query: 273 MLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRACIK 321
           ++ A  DTTS T+   +Y +A + D QQKL+EE+ +    ++           YL   + 
Sbjct: 302 IIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVN 361

Query: 322 EAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLT 381
           E +R+ PVVS   R   K+  I G  IP+ + +      L    KY+  P +F PER+  
Sbjct: 362 ETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSK 421

Query: 382 NKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
              D +       +   PFG G R+CIG R A   ++  + + ++NF
Sbjct: 422 KNKDSI-----DLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNF 463


>AF280108-1|AAG33009.1|  503|Homo sapiens cytochrome P450 subfamily
           IIIA polypeptide 43 protein.
          Length = 503

 Score = 75.4 bits (177), Expect = 4e-13
 Identities = 50/167 (29%), Positives = 80/167 (47%), Gaps = 16/167 (9%)

Query: 273 MLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRACIK 321
           ++ A  DTTS T+   +Y +A + D QQKL+EE+ +    ++           YL   + 
Sbjct: 302 IIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVN 361

Query: 322 EAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLT 381
           E +R+ PVVS   R   K+  I G  IP+ + +      L    KY+  P +F PER+  
Sbjct: 362 ETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSK 421

Query: 382 NKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
              D +       +   PFG G R+CIG R A   ++  + + ++NF
Sbjct: 422 KNKDSI-----DLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNF 463


>AC011904-4|AAS07395.1|  503|Homo sapiens unknown protein.
          Length = 503

 Score = 75.4 bits (177), Expect = 4e-13
 Identities = 50/167 (29%), Positives = 80/167 (47%), Gaps = 16/167 (9%)

Query: 273 MLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRACIK 321
           ++ A  DTTS T+   +Y +A + D QQKL+EE+ +    ++           YL   + 
Sbjct: 302 IIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVN 361

Query: 322 EAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLT 381
           E +R+ PVVS   R   K+  I G  IP+ + +      L    KY+  P +F PER+  
Sbjct: 362 ETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSK 421

Query: 382 NKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
              D +       +   PFG G R+CIG R A   ++  + + ++NF
Sbjct: 422 KNKDSI-----DLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNF 463


>AM183947-1|CAJ75801.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 74.9 bits (176), Expect = 5e-13
 Identities = 59/189 (31%), Positives = 97/189 (51%), Gaps = 24/189 (12%)

Query: 263 EEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG----------- 311
           E + ++ A D+L+ G +TT+NT+S  +  +  + + QQ+L+EE+  + G           
Sbjct: 278 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYK 337

Query: 312 ---KRSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKY 367
              +   L A I E +R+ PVV   +  RTT+  +I GY IPE   I    Q   + E  
Sbjct: 338 DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETV 397

Query: 368 YPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVEN 427
           + RP EF P+R+L    +P    N+   A   FG G R C+G  +A LE+   L+++++ 
Sbjct: 398 WERPHEFWPDRFL----EP--GKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQA 448

Query: 428 FQVEWSGSS 436
           F +  SG +
Sbjct: 449 FTLLPSGDA 457


>AM086564-1|CAJ31103.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 74.9 bits (176), Expect = 5e-13
 Identities = 59/189 (31%), Positives = 97/189 (51%), Gaps = 24/189 (12%)

Query: 263 EEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG----------- 311
           E + ++ A D+L+ G +TT+NT+S  +  +  + + QQ+L+EE+  + G           
Sbjct: 278 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYK 337

Query: 312 ---KRSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKY 367
              +   L A I E +R+ PVV   +  RTT+  +I GY IPE   I    Q   + E  
Sbjct: 338 DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETV 397

Query: 368 YPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVEN 427
           + RP EF P+R+L    +P    N+   A   FG G R C+G  +A LE+   L+++++ 
Sbjct: 398 WERPHEFWPDRFL----EP--GKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQA 448

Query: 428 FQVEWSGSS 436
           F +  SG +
Sbjct: 449 FTLLPSGDA 457


>AF233624-1|AAF99278.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score = 74.9 bits (176), Expect = 5e-13
 Identities = 63/226 (27%), Positives = 94/226 (41%), Gaps = 20/226 (8%)

Query: 242 KMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQK 301
           K N S+     P + + L ++E      A   L+AG +  +NT+S   YL+A N D Q+K
Sbjct: 311 KPNPSRQHQPSP-MARPLTVDEIVG--QAFIFLIAGYEIITNTLSFATYLLATNPDCQEK 367

Query: 302 LREEVMSKNGKRS------------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIP 349
           L  EV     K              YL   I E +R+ P      R   ++  +LG  IP
Sbjct: 368 LLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIP 427

Query: 350 ENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIG 409
               +  A   L    +++P P  F PER+              PF   PFG G RSC+G
Sbjct: 428 AGAVLEMAVGALHHDPEHWPSPENFNPERFTAEARQ-----QHRPFTYLPFGAGPRSCLG 482

Query: 410 RRIAELEVETFLSKIVENFQVEWSGSSPRVEQTSINYFKGPFNFIF 455
            R+  LEV+  L  ++  F+ +    +    Q       GP N ++
Sbjct: 483 VRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVY 528


>M80647-1|AAA60618.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score = 74.5 bits (175), Expect = 7e-13
 Identities = 63/226 (27%), Positives = 94/226 (41%), Gaps = 20/226 (8%)

Query: 242 KMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQK 301
           K N S+     P + + L ++E      A   L+AG +  +NT+S   YL+A N D Q+K
Sbjct: 311 KPNPSRQHQPSP-MARPLTVDEIVG--QAFIFLIAGYEIITNTLSFATYLLATNPDCQEK 367

Query: 302 LREEVMSKNGKRS------------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIP 349
           L  EV     K              YL   I E +R+ P      R   ++  +LG  IP
Sbjct: 368 LLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIP 427

Query: 350 ENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIG 409
               +  A   L    +++P P  F PER+              PF   PFG G RSC+G
Sbjct: 428 AGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQ-----QHRPFTYLPFGAGPRSCLG 482

Query: 410 RRIAELEVETFLSKIVENFQVEWSGSSPRVEQTSINYFKGPFNFIF 455
            R+  LEV+  L  ++  F+ +    +    Q       GP N ++
Sbjct: 483 VRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVY 528


>BC041157-1|AAH41157.1|  534|Homo sapiens thromboxane A synthase 1
           (platelet, cytochrome P450, family 5, subfamily A)
           protein.
          Length = 534

 Score = 74.5 bits (175), Expect = 7e-13
 Identities = 63/226 (27%), Positives = 94/226 (41%), Gaps = 20/226 (8%)

Query: 242 KMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQK 301
           K N S+     P + + L ++E      A   L+AG +  +NT+S   YL+A N D Q+K
Sbjct: 311 KPNPSRQHQPSP-MARPLTVDEIVG--QAFIFLIAGYEIITNTLSFATYLLATNPDCQEK 367

Query: 302 LREEVMSKNGKRS------------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIP 349
           L  EV     K              YL   I E +R+ P      R   ++  +LG  IP
Sbjct: 368 LLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIP 427

Query: 350 ENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIG 409
               +  A   L    +++P P  F PER+              PF   PFG G RSC+G
Sbjct: 428 AGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQ-----QHRPFTYLPFGAGPRSCLG 482

Query: 410 RRIAELEVETFLSKIVENFQVEWSGSSPRVEQTSINYFKGPFNFIF 455
            R+  LEV+  L  ++  F+ +    +    Q       GP N ++
Sbjct: 483 VRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVY 528


>BC014117-1|AAH14117.1|  466|Homo sapiens TBXAS1 protein protein.
          Length = 466

 Score = 74.5 bits (175), Expect = 7e-13
 Identities = 63/226 (27%), Positives = 94/226 (41%), Gaps = 20/226 (8%)

Query: 242 KMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQK 301
           K N S+     P + + L ++E      A   L+AG +  +NT+S   YL+A N D Q+K
Sbjct: 243 KPNPSRQHQPSP-MARPLTVDEIVG--QAFIFLIAGYEIITNTLSFATYLLATNPDCQEK 299

Query: 302 LREEVMSKNGKRS------------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIP 349
           L  EV     K              YL   I E +R+ P      R   ++  +LG  IP
Sbjct: 300 LLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIP 359

Query: 350 ENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIG 409
               +  A   L    +++P P  F PER+              PF   PFG G RSC+G
Sbjct: 360 AGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQ-----QHRPFTYLPFGAGPRSCLG 414

Query: 410 RRIAELEVETFLSKIVENFQVEWSGSSPRVEQTSINYFKGPFNFIF 455
            R+  LEV+  L  ++  F+ +    +    Q       GP N ++
Sbjct: 415 VRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVY 460


>AK223466-1|BAD97186.1|  534|Homo sapiens thromboxane A synthase 1
           (platelet, cytochrome P450, family 5, subfamily A) iso
           protein.
          Length = 534

 Score = 74.5 bits (175), Expect = 7e-13
 Identities = 63/226 (27%), Positives = 94/226 (41%), Gaps = 20/226 (8%)

Query: 242 KMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQK 301
           K N S+     P + + L ++E      A   L+AG +  +NT+S   YL+A N D Q+K
Sbjct: 311 KPNPSRQHQPSP-MARPLTVDEIVG--QAFIFLIAGYEIITNTLSFATYLLATNPDCQEK 367

Query: 302 LREEVMSKNGKRS------------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIP 349
           L  EV     K              YL   I E +R+ P      R   ++  +LG  IP
Sbjct: 368 LLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIP 427

Query: 350 ENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIG 409
               +  A   L    +++P P  F PER+              PF   PFG G RSC+G
Sbjct: 428 AGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQ-----QHRPFTYLPFGAGPRSCLG 482

Query: 410 RRIAELEVETFLSKIVENFQVEWSGSSPRVEQTSINYFKGPFNFIF 455
            R+  LEV+  L  ++  F+ +    +    Q       GP N ++
Sbjct: 483 VRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVY 528


>AF233625-1|AAF99279.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score = 74.5 bits (175), Expect = 7e-13
 Identities = 63/226 (27%), Positives = 94/226 (41%), Gaps = 20/226 (8%)

Query: 242 KMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQK 301
           K N S+     P + + L ++E      A   L+AG +  +NT+S   YL+A N D Q+K
Sbjct: 311 KPNPSRQHQPSP-MARPLTVDEIVG--QAFIFLIAGYEIITNTLSFATYLLATNPDCQEK 367

Query: 302 LREEVMSKNGKRS------------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIP 349
           L  EV     K              YL   I E +R+ P      R   ++  +LG  IP
Sbjct: 368 LLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIP 427

Query: 350 ENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIG 409
               +  A   L    +++P P  F PER+              PF   PFG G RSC+G
Sbjct: 428 AGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQ-----QHQPFTYLPFGAGPRSCLG 482

Query: 410 RRIAELEVETFLSKIVENFQVEWSGSSPRVEQTSINYFKGPFNFIF 455
            R+  LEV+  L  ++  F+ +    +    Q       GP N ++
Sbjct: 483 VRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVY 528


>AF233623-1|AAF99277.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score = 74.5 bits (175), Expect = 7e-13
 Identities = 63/226 (27%), Positives = 94/226 (41%), Gaps = 20/226 (8%)

Query: 242 KMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQK 301
           K N S+     P + + L ++E      A   L+AG +  +NT+S   YL+A N D Q+K
Sbjct: 311 KPNPSRQHQPSP-MARPLTVDEIVG--QAFIFLIAGYEIITNTLSFATYLLATNPDCQEK 367

Query: 302 LREEVMSKNGKRS------------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIP 349
           L  EV     K              YL   I E +R+ P      R   ++  +LG  IP
Sbjct: 368 LLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIP 427

Query: 350 ENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIG 409
               +  A   L    +++P P  F PER+              PF   PFG G RSC+G
Sbjct: 428 AGAVLEMAVGALHHDPEHWPSPKTFNPERFTAEARQ-----QHRPFTYLPFGAGPRSCLG 482

Query: 410 RRIAELEVETFLSKIVENFQVEWSGSSPRVEQTSINYFKGPFNFIF 455
            R+  LEV+  L  ++  F+ +    +    Q       GP N ++
Sbjct: 483 VRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVY 528


>AF233622-1|AAF99276.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score = 74.5 bits (175), Expect = 7e-13
 Identities = 63/226 (27%), Positives = 94/226 (41%), Gaps = 20/226 (8%)

Query: 242 KMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQK 301
           K N S+     P + + L ++E      A   L+AG +  +NT+S   YL+A N D Q+K
Sbjct: 311 KPNPSRQHQPSP-MARPLTVDEIVG--QAFIFLIAGYEIITNTLSFATYLLATNPDCQEK 367

Query: 302 LREEVMSKNGKRS------------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIP 349
           L  EV     K              YL   I E +R+ P      R   ++  +LG  IP
Sbjct: 368 LLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAEDCEVLGQRIP 427

Query: 350 ENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIG 409
               +  A   L    +++P P  F PER+              PF   PFG G RSC+G
Sbjct: 428 AGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQ-----QHRPFTYLPFGAGPRSCLG 482

Query: 410 RRIAELEVETFLSKIVENFQVEWSGSSPRVEQTSINYFKGPFNFIF 455
            R+  LEV+  L  ++  F+ +    +    Q       GP N ++
Sbjct: 483 VRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVY 528


>AF233620-1|AAF99274.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score = 74.5 bits (175), Expect = 7e-13
 Identities = 63/226 (27%), Positives = 94/226 (41%), Gaps = 20/226 (8%)

Query: 242 KMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQK 301
           K N S+     P + + L ++E      A   L+AG +  +NT+S   YL+A N D Q+K
Sbjct: 311 KPNPSRQHQPSP-MARPLTVDEIVG--QAFIFLIAGYEIITNTLSFATYLLATNPDCQEK 367

Query: 302 LREEVMSKNGKRS------------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIP 349
           L  EV     K              YL   I E +R+ P      R   ++  +LG  IP
Sbjct: 368 LLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIP 427

Query: 350 ENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIG 409
               +  A   L    +++P P  F PER+              PF   PFG G RSC+G
Sbjct: 428 AGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQ-----QHRPFTYLPFGAGPRSCLG 482

Query: 410 RRIAELEVETFLSKIVENFQVEWSGSSPRVEQTSINYFKGPFNFIF 455
            R+  LEV+  L  ++  F+ +    +    Q       GP N ++
Sbjct: 483 VRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVY 528


>AF233619-1|AAF99273.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score = 74.5 bits (175), Expect = 7e-13
 Identities = 63/226 (27%), Positives = 94/226 (41%), Gaps = 20/226 (8%)

Query: 242 KMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQK 301
           K N S+     P + + L ++E      A   L+AG +  +NT+S   YL+A N D Q+K
Sbjct: 311 KPNPSRQHQPSP-MARPLTVDEIVG--QAFIFLIAGYEIITNTLSFATYLLATNPDCQEK 367

Query: 302 LREEVMSKNGKRS------------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIP 349
           L  EV     K              YL   I E +R+ P      R   ++  +LG  IP
Sbjct: 368 LLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIP 427

Query: 350 ENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIG 409
               +  A   L    +++P P  F PER+              PF   PFG G RSC+G
Sbjct: 428 AGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQ-----QHRPFTYLPFGAGPRSCLG 482

Query: 410 RRIAELEVETFLSKIVENFQVEWSGSSPRVEQTSINYFKGPFNFIF 455
            R+  LEV+  L  ++  F+ +    +    Q       GP N ++
Sbjct: 483 VRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVY 528


>AF233618-1|AAF99272.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score = 74.5 bits (175), Expect = 7e-13
 Identities = 63/226 (27%), Positives = 94/226 (41%), Gaps = 20/226 (8%)

Query: 242 KMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQK 301
           K N S+     P + + L ++E      A   L+AG +  +NT+S   YL+A N D Q+K
Sbjct: 311 KPNPSRQHQPSP-MARPLTVDEIVG--QAFIFLIAGYEIITNTLSFATYLLATNPDCQEK 367

Query: 302 LREEVMSKNGKRS------------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIP 349
           L  EV     K              YL   I E +R+ P      R   ++  +LG  IP
Sbjct: 368 LLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIP 427

Query: 350 ENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIG 409
               +  A   L    +++P P  F PER+              PF   PFG G RSC+G
Sbjct: 428 AGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQ-----QHRPFTYLPFGAGPRSCLG 482

Query: 410 RRIAELEVETFLSKIVENFQVEWSGSSPRVEQTSINYFKGPFNFIF 455
            R+  LEV+  L  ++  F+ +    +    Q       GP N ++
Sbjct: 483 VRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVY 528


>AF233617-1|AAF99271.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score = 74.5 bits (175), Expect = 7e-13
 Identities = 63/226 (27%), Positives = 94/226 (41%), Gaps = 20/226 (8%)

Query: 242 KMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQK 301
           K N S+     P + + L ++E      A   L+AG +  +NT+S   YL+A N D Q+K
Sbjct: 311 KPNPSRQHQPSP-MARPLTVDEIVG--QAFIFLIAGYEIITNTLSFATYLLATNPDCQEK 367

Query: 302 LREEVMSKNGKRS------------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIP 349
           L  EV     K              YL   I E +R+ P      R   ++  +LG  IP
Sbjct: 368 LLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIP 427

Query: 350 ENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIG 409
               +  A   L    +++P P  F PER+              PF   PFG G RSC+G
Sbjct: 428 AGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQ-----QHRPFTYLPFGAGPRSCLG 482

Query: 410 RRIAELEVETFLSKIVENFQVEWSGSSPRVEQTSINYFKGPFNFIF 455
            R+  LEV+  L  ++  F+ +    +    Q       GP N ++
Sbjct: 483 VRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVY 528


>AF233616-1|AAF99270.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score = 74.5 bits (175), Expect = 7e-13
 Identities = 63/226 (27%), Positives = 94/226 (41%), Gaps = 20/226 (8%)

Query: 242 KMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQK 301
           K N S+     P + + L ++E      A   L+AG +  +NT+S   YL+A N D Q+K
Sbjct: 311 KPNPSRQHQPSP-MARPLTVDEIVG--QAFIFLIAGYEIITNTLSFATYLLATNPDCQEK 367

Query: 302 LREEVMSKNGKRS------------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIP 349
           L  EV     K              YL   I E +R+ P      R   ++  +LG  IP
Sbjct: 368 LLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIP 427

Query: 350 ENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIG 409
               +  A   L    +++P P  F PER+              PF   PFG G RSC+G
Sbjct: 428 AGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQ-----QHRPFTYLPFGAGPRSCLG 482

Query: 410 RRIAELEVETFLSKIVENFQVEWSGSSPRVEQTSINYFKGPFNFIF 455
            R+  LEV+  L  ++  F+ +    +    Q       GP N ++
Sbjct: 483 VRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVY 528


>AF233615-1|AAF99269.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score = 74.5 bits (175), Expect = 7e-13
 Identities = 63/226 (27%), Positives = 94/226 (41%), Gaps = 20/226 (8%)

Query: 242 KMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQK 301
           K N S+     P + + L ++E      A   L+AG +  +NT+S   YL+A N D Q+K
Sbjct: 311 KPNPSRQHQPSP-MARPLTVDEIVG--QAFIFLIAGYEIITNTLSFATYLLATNPDCQEK 367

Query: 302 LREEVMSKNGKRS------------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIP 349
           L  EV     K              YL   I E +R+ P      R   ++  +LG  IP
Sbjct: 368 LLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIP 427

Query: 350 ENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIG 409
               +  A   L    +++P P  F PER+              PF   PFG G RSC+G
Sbjct: 428 AGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQ-----QHRPFTYLPFGAGPRSCLG 482

Query: 410 RRIAELEVETFLSKIVENFQVEWSGSSPRVEQTSINYFKGPFNFIF 455
            R+  LEV+  L  ++  F+ +    +    Q       GP N ++
Sbjct: 483 VRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVY 528


>BC132767-1|AAI32768.1|  544|Homo sapiens cytochrome P450, family 2,
           subfamily U, polypeptide 1 protein.
          Length = 544

 Score = 74.1 bits (174), Expect = 9e-13
 Identities = 49/179 (27%), Positives = 87/179 (48%), Gaps = 17/179 (9%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           +EEY + +  D+ +AG DTT+N++   L  M++N D Q+K+ EE+           ++  
Sbjct: 338 DEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDK 397

Query: 311 GKRSYLRACIKEAMRILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYP 369
            +  Y  A I E  R+  VV   +   T E  +L GY IP+   I      +      + 
Sbjct: 398 AQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWE 457

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
           +P +F P R+L ++   +       F   PFG G R C+G ++A++E+      ++++F
Sbjct: 458 KPEDFYPNRFLDDQGQLI---KKETFI--PFGIGKRVCMGEQLAKMELFLMFVSLMQSF 511


>AY343323-1|AAQ21380.1|  544|Homo sapiens cytochrome P450 protein.
          Length = 544

 Score = 74.1 bits (174), Expect = 9e-13
 Identities = 49/179 (27%), Positives = 87/179 (48%), Gaps = 17/179 (9%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           +EEY + +  D+ +AG DTT+N++   L  M++N D Q+K+ EE+           ++  
Sbjct: 338 DEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDK 397

Query: 311 GKRSYLRACIKEAMRILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYP 369
            +  Y  A I E  R+  VV   +   T E  +L GY IP+   I      +      + 
Sbjct: 398 AQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWE 457

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
           +P +F P R+L ++   +       F   PFG G R C+G ++A++E+      ++++F
Sbjct: 458 KPEDFYPNRFLDDQGQLI---KKETFI--PFGIGKRVCMGEQLAKMELFLMFVSLMQSF 511


>AM183948-1|CAJ75802.1|  494|Homo sapiens steroid 21-hydroxylase
           protein.
          Length = 494

 Score = 74.1 bits (174), Expect = 9e-13
 Identities = 87/367 (23%), Positives = 170/367 (46%), Gaps = 42/367 (11%)

Query: 94  VSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQE 153
           + D+  LWK+ +      LL      +    +E++  +  ER+R+       I    ++E
Sbjct: 109 LGDYSLLWKAHKKLTRSALLLGIRDSM-EPVVEQLTQEFCERMRAQPGTPVAI----EEE 163

Query: 154 MNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNEL-DLKPSIWTYVS 212
            +L +   I  +  G+++   D NL   +  K + E +      S ++ D+ P +  +  
Sbjct: 164 FSLLTCSIICYLTFGDKIK--DDNLMP-AYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFP 219

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDI-------KMNKSKSDDEKPVLEKLL-DINEE 264
            P  R+  +  E+++++ +  +++  + +        M+       +P +E+    + E 
Sbjct: 220 NPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEG 279

Query: 265 YAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG------------- 311
           + ++ A D+L+ G + T+NT+S  +  +  + + QQ+L+EE+  + G             
Sbjct: 280 HVHMAAVDLLIGGTENTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDR 339

Query: 312 -KRSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
            +   L A I E +R+ PVV   +  RTT+  +I GY IPE   I    Q   + E  + 
Sbjct: 340 ARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWE 399

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           RP EF P+R+L    +P    N+   A   FG G R C+G  +A LE+   L+++++ F 
Sbjct: 400 RPHEFWPDRFL----EP--GKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFT 450

Query: 430 VEWSGSS 436
           +  SG +
Sbjct: 451 LLPSGDA 457


>M17252-1|AAA59985.1|  230|Homo sapiens CYP21 protein.
          Length = 230

 Score = 73.3 bits (172), Expect = 2e-12
 Identities = 59/189 (31%), Positives = 97/189 (51%), Gaps = 24/189 (12%)

Query: 263 EEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG----------- 311
           E + ++ A D+L+ G +TT+NT+S  +  +  + + QQ+L+EE+  + G           
Sbjct: 14  EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHLEIQQRLQEELDHELGPGASSSRVPYK 73

Query: 312 ---KRSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKY 367
              +   L A I E +R+ PVV   +  RTT+  +I GY IPE   I    Q   + E  
Sbjct: 74  DRARLPLLIATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETV 133

Query: 368 YPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVEN 427
           + RP EF P+R+L    +P    N+   A   FG G R C+G  +A LE+   L+++++ 
Sbjct: 134 WERPHEFWPDRFL----EP--GKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQA 184

Query: 428 FQVEWSGSS 436
           F +  SG +
Sbjct: 185 FTLLPSGDA 193


>AM183950-1|CAJ75804.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 73.3 bits (172), Expect = 2e-12
 Identities = 87/367 (23%), Positives = 170/367 (46%), Gaps = 42/367 (11%)

Query: 94  VSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQE 153
           + D+  LWK+ +      LL      +    +E++  +  ER+R+       I    ++E
Sbjct: 109 LGDYSLLWKAHKKLTRSALLLGIRDSM-EPVVEQLTQEFCERMRAQPGTPVAI----EEE 163

Query: 154 MNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNEL-DLKPSIWTYVS 212
            +L +   I  +  G+++   D NL   +  K + E +      S ++ D+ P +  +  
Sbjct: 164 FSLLTCSIICYLTFGDKIK--DDNLMP-AYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFP 219

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDI-------KMNKSKSDDEKPVLEKLL-DINEE 264
            P  R+  +  E+++++ +  +++  + +        M+       +P +E+    + E 
Sbjct: 220 NPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEG 279

Query: 265 YAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG------------- 311
           + ++ A D+L+ G +TT+NT+S  +  +  + + QQ+L+EE+  + G             
Sbjct: 280 HVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDR 339

Query: 312 -KRSYLRACIKEAMRILPVVSGNMRR-TTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
            +   L A I E +R+ PVV   +   TT+  +I GY IPE   I    Q   + E  + 
Sbjct: 340 ARLPLLNATIAEVLRLRPVVPLALPHCTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWE 399

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           RP EF P+R+L    +P    N+   A   FG G R C+G  +A LE+   L+++++ F 
Sbjct: 400 RPHEFWPDRFL----EP--GKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFT 450

Query: 430 VEWSGSS 436
           +  SG +
Sbjct: 451 LLPSGDA 457


>AF233621-1|AAF99275.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score = 73.3 bits (172), Expect = 2e-12
 Identities = 62/226 (27%), Positives = 94/226 (41%), Gaps = 20/226 (8%)

Query: 242 KMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQK 301
           K N S+     P + + L ++E      A   L+AG +  +NT+S   Y++A N D Q+K
Sbjct: 311 KPNPSRQHQPSP-MARPLTVDEIVG--QAFIFLIAGYEIITNTLSFATYVLATNPDCQEK 367

Query: 302 LREEVMSKNGKRS------------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIP 349
           L  EV     K              YL   I E +R+ P      R   ++  +LG  IP
Sbjct: 368 LLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIP 427

Query: 350 ENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIG 409
               +  A   L    +++P P  F PER+              PF   PFG G RSC+G
Sbjct: 428 AGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQ-----QHRPFTYLPFGAGPRSCLG 482

Query: 410 RRIAELEVETFLSKIVENFQVEWSGSSPRVEQTSINYFKGPFNFIF 455
            R+  LEV+  L  ++  F+ +    +    Q       GP N ++
Sbjct: 483 VRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVY 528


>BC104909-1|AAI04910.1|  501|Homo sapiens cytochrome P450, family 2,
           subfamily R, polypeptide 1 protein.
          Length = 501

 Score = 72.9 bits (171), Expect = 2e-12
 Identities = 53/216 (24%), Positives = 101/216 (46%), Gaps = 26/216 (12%)

Query: 229 LTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVAGVDTTSNTMSAT 288
           L ++F+   LD+  M++ K+D            ++E       ++++AG +TT+N +   
Sbjct: 272 LPQHFVDAYLDE--MDQGKNDPSST-------FSKENLIFSVGELIIAGTETTTNVLRWA 322

Query: 289 LYLMAINQDKQQKLREEV---MSKNGKRS--------YLRACIKEAMRILPVVS-GNMRR 336
           +  MA+  + Q ++++E+   M  NGK S        Y  A + E +R   +V  G    
Sbjct: 323 ILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHA 382

Query: 337 TTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFA 396
           T+++  + GY IP+   +      +   EKY+  P  F PER+L +     Y+       
Sbjct: 383 TSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSG---YFAKKEALV 439

Query: 397 NSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVEW 432
             PF  G R C+G  +A +E+  F + +++ F + +
Sbjct: 440 --PFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHF 473


>BC104907-1|AAI04908.1|  501|Homo sapiens cytochrome P450, family 2,
           subfamily R, polypeptide 1 protein.
          Length = 501

 Score = 72.9 bits (171), Expect = 2e-12
 Identities = 53/216 (24%), Positives = 101/216 (46%), Gaps = 26/216 (12%)

Query: 229 LTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVAGVDTTSNTMSAT 288
           L ++F+   LD+  M++ K+D            ++E       ++++AG +TT+N +   
Sbjct: 272 LPQHFVDAYLDE--MDQGKNDPSST-------FSKENLIFSVGELIIAGTETTTNVLRWA 322

Query: 289 LYLMAINQDKQQKLREEV---MSKNGKRS--------YLRACIKEAMRILPVVS-GNMRR 336
           +  MA+  + Q ++++E+   M  NGK S        Y  A + E +R   +V  G    
Sbjct: 323 ILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHA 382

Query: 337 TTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFA 396
           T+++  + GY IP+   +      +   EKY+  P  F PER+L +     Y+       
Sbjct: 383 TSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSG---YFAKKEALV 439

Query: 397 NSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVEW 432
             PF  G R C+G  +A +E+  F + +++ F + +
Sbjct: 440 --PFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHF 473


>AY323817-1|AAQ23114.1|  501|Homo sapiens cytochrome P450 2R1
           protein.
          Length = 501

 Score = 72.9 bits (171), Expect = 2e-12
 Identities = 53/216 (24%), Positives = 101/216 (46%), Gaps = 26/216 (12%)

Query: 229 LTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVAGVDTTSNTMSAT 288
           L ++F+   LD+  M++ K+D            ++E       ++++AG +TT+N +   
Sbjct: 272 LPQHFVDAYLDE--MDQGKNDPSST-------FSKENLIFSVGELIIAGTETTTNVLRWA 322

Query: 289 LYLMAINQDKQQKLREEV---MSKNGKRS--------YLRACIKEAMRILPVVS-GNMRR 336
           +  MA+  + Q ++++E+   M  NGK S        Y  A + E +R   +V  G    
Sbjct: 323 ILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHA 382

Query: 337 TTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFA 396
           T+++  + GY IP+   +      +   EKY+  P  F PER+L +     Y+       
Sbjct: 383 TSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSG---YFAKKEALV 439

Query: 397 NSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVEW 432
             PF  G R C+G  +A +E+  F + +++ F + +
Sbjct: 440 --PFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHF 473


>D34625-1|BAA07011.1|  533|Homo sapiens thromboxane synthase
           protein.
          Length = 533

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 62/226 (27%), Positives = 93/226 (41%), Gaps = 20/226 (8%)

Query: 242 KMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQK 301
           K N S+     P + + L ++E      A   L+AG +  +NT+S   YL+A N D Q+K
Sbjct: 310 KPNPSRQHQPSP-MARPLTVDEIVG--QAFIFLIAGYEIITNTLSFATYLLATNPDCQEK 366

Query: 302 LREEVMSKNGKRS------------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIP 349
           L  EV     K              YL   I E +R+ P      R   ++  +LG  IP
Sbjct: 367 LLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIP 426

Query: 350 ENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIG 409
               +  A   L    +++P P  F PER+              PF   PFG G RSC+G
Sbjct: 427 AGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQ-----QHRPFTYLPFGAGPRSCLG 481

Query: 410 RRIAELEVETFLSKIVENFQVEWSGSSPRVEQTSINYFKGPFNFIF 455
             +  LEV+  L  ++  F+ +    +    Q       GP N ++
Sbjct: 482 VHLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVY 527


>AF280109-1|AAG33010.1|  504|Homo sapiens cytochrome P450 subfamily
           IIIA polypeptide 43 protein.
          Length = 504

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 49/167 (29%), Positives = 80/167 (47%), Gaps = 15/167 (8%)

Query: 273 MLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRACIK 321
           ++ A  DTTS T+   +Y +A + D QQKL+EE+ +    ++           YL   + 
Sbjct: 302 IIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVN 361

Query: 322 EAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLT 381
           E +R+ PVVS   R   K+  I G  IP+ + +      L    KY+  P +F PE   +
Sbjct: 362 ETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFS 421

Query: 382 NKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
            K+      +   +   PFG G R+CIG R A   ++  + + ++NF
Sbjct: 422 KKNK----DSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNF 464


>AC011904-5|AAS07394.1|  504|Homo sapiens unknown protein.
          Length = 504

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 49/167 (29%), Positives = 80/167 (47%), Gaps = 15/167 (8%)

Query: 273 MLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS-----------YLRACIK 321
           ++ A  DTTS T+   +Y +A + D QQKL+EE+ +    ++           YL   + 
Sbjct: 302 IIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVN 361

Query: 322 EAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLT 381
           E +R+ PVVS   R   K+  I G  IP+ + +      L    KY+  P +F PE   +
Sbjct: 362 ETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFS 421

Query: 382 NKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
            K+      +   +   PFG G R+CIG R A   ++  + + ++NF
Sbjct: 422 KKNK----DSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNF 464


>M12792-1|AAB59440.1|  494|Homo sapiens steroid 21-hydroxylase
           protein.
          Length = 494

 Score = 72.1 bits (169), Expect = 4e-12
 Identities = 86/367 (23%), Positives = 170/367 (46%), Gaps = 42/367 (11%)

Query: 94  VSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQE 153
           + D+  LWK+ +      LL      +    +E++  +  ER+R+       I    ++E
Sbjct: 109 LGDYSLLWKAHKKLTRSALLLGIRDSM-EPVVEQLTQEFCERMRAQPGTPVAI----EEE 163

Query: 154 MNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNEL-DLKPSIWTYVS 212
            +L +   I  +  G+++   D NL   +  K + E +      S ++ D+ P +  +  
Sbjct: 164 FSLLTCSIICYLTFGDKIK--DDNLMP-AYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFP 219

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDI-------KMNKSKSDDEKPVLEKLL-DINEE 264
            P  R+  +  E+++++ +  +++  + +        M+       +P +E+    + E 
Sbjct: 220 NPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEG 279

Query: 265 YAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG------------- 311
           + ++ A D+L+ G +TT+NT+S  +  +  + + QQ+L+EE+  + G             
Sbjct: 280 HVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDR 339

Query: 312 -KRSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
            +   L A I E +R+ PVV   +  RTT+  +I GY IPE   I    Q   + E  + 
Sbjct: 340 ARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWE 399

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           RP EF P+R+L    +P    N+   A   FG G   C+G  +A L++   L+++++ F 
Sbjct: 400 RPHEFWPDRFL----EP--GKNSRALA---FGCGAPVCLGEPLARLDLFVVLTRLLQAFT 450

Query: 430 VEWSGSS 436
           +  SG +
Sbjct: 451 LLPSGDA 457


>AY358631-1|AAQ88994.1|  505|Homo sapiens EPSW3060 protein.
          Length = 505

 Score = 72.1 bits (169), Expect = 4e-12
 Identities = 85/372 (22%), Positives = 158/372 (42%), Gaps = 39/372 (10%)

Query: 92  GLVSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFD 151
           GLV+  G  WK  R  V P       ++++ + + E    M+ +      +N+R+  +  
Sbjct: 124 GLVTLDGSKWKKHRQIVKPGF-NISILKIFITMMSESVRMMLNKWEEHIAQNSRL--ELF 180

Query: 152 QEMNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNE-----LDLKPS 206
           Q ++L +L+SI   A  ++      ++Q DS +   ++ V  +  +SN+     L     
Sbjct: 181 QHVSLMTLDSIMKCAFSHQ-----GSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDL 235

Query: 207 IWTYVST-PLFRK-TMKMYEEQENLTKYFIKKALDDIKMNKSKSD--DEKPVL-----EK 257
           ++ + S   +F K   ++++  E + +   +   D +K + ++    D   +L     E 
Sbjct: 236 VFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSEN 295

Query: 258 LLDINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS--- 314
             D +E          + AG DTTS+ +S  LY +A   + QQ+ R+E+    G  S   
Sbjct: 296 TKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSIT 355

Query: 315 --------YLRACIKEAMRILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMME 365
                   Y   CIKE +R+   V    R   K      G  +P  + +      L    
Sbjct: 356 WEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNP 415

Query: 366 KYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIV 425
            ++  P  F P R+    S+ +     HP+A  PF  G+R+CIG+  A +E +  ++  +
Sbjct: 416 YFWEDPQVFNPLRFSRENSEKI-----HPYAFIPFSAGLRNCIGQHFAIIECKVAVALTL 470

Query: 426 ENFQVEWSGSSP 437
             F++    S P
Sbjct: 471 LRFKLAPDHSRP 482


>AY262056-1|AAO89257.1|  505|Homo sapiens cytochrome P450 protein.
          Length = 505

 Score = 72.1 bits (169), Expect = 4e-12
 Identities = 85/372 (22%), Positives = 158/372 (42%), Gaps = 39/372 (10%)

Query: 92  GLVSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFD 151
           GLV+  G  WK  R  V P       ++++ + + E    M+ +      +N+R+  +  
Sbjct: 124 GLVTLDGSKWKKHRQIVKPGF-NISILKIFITMMSESVRMMLNKWEEHIAQNSRL--ELF 180

Query: 152 QEMNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNE-----LDLKPS 206
           Q ++L +L+SI   A  ++      ++Q DS +   ++ V  +  +SN+     L     
Sbjct: 181 QHVSLMTLDSIMKCAFSHQ-----GSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDL 235

Query: 207 IWTYVST-PLFRK-TMKMYEEQENLTKYFIKKALDDIKMNKSKSD--DEKPVL-----EK 257
           ++ + S   +F K   ++++  E + +   +   D +K + ++    D   +L     E 
Sbjct: 236 VFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSEN 295

Query: 258 LLDINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS--- 314
             D +E          + AG DTTS+ +S  LY +A   + QQ+ R+E+    G  S   
Sbjct: 296 TKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSIT 355

Query: 315 --------YLRACIKEAMRILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMME 365
                   Y   CIKE +R+   V    R   K      G  +P  + +      L    
Sbjct: 356 WEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNP 415

Query: 366 KYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIV 425
            ++  P  F P R+    S+ +     HP+A  PF  G+R+CIG+  A +E +  ++  +
Sbjct: 416 YFWEDPQVFNPLRFSRENSEKI-----HPYAFIPFSAGLRNCIGQHFAIIECKVAVALTL 470

Query: 426 ENFQVEWSGSSP 437
             F++    S P
Sbjct: 471 LRFKLAPDHSRP 482


>AL450996-2|CAH71036.1|  505|Homo sapiens cytochrome P450, family 4,
           subfamily Z, polypeptide 1 protein.
          Length = 505

 Score = 72.1 bits (169), Expect = 4e-12
 Identities = 85/372 (22%), Positives = 158/372 (42%), Gaps = 39/372 (10%)

Query: 92  GLVSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFD 151
           GLV+  G  WK  R  V P       ++++ + + E    M+ +      +N+R+  +  
Sbjct: 124 GLVTLDGSKWKKHRQIVKPGF-NISILKIFITMMSESVRMMLNKWEEHIAQNSRL--ELF 180

Query: 152 QEMNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNE-----LDLKPS 206
           Q ++L +L+SI   A  ++      ++Q DS +   ++ V  +  +SN+     L     
Sbjct: 181 QHVSLMTLDSIMKCAFSHQ-----GSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDL 235

Query: 207 IWTYVST-PLFRK-TMKMYEEQENLTKYFIKKALDDIKMNKSKSD--DEKPVL-----EK 257
           ++ + S   +F K   ++++  E + +   +   D +K + ++    D   +L     E 
Sbjct: 236 VFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSEN 295

Query: 258 LLDINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS--- 314
             D +E          + AG DTTS+ +S  LY +A   + QQ+ R+E+    G  S   
Sbjct: 296 TKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSIT 355

Query: 315 --------YLRACIKEAMRILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMME 365
                   Y   CIKE +R+   V    R   K      G  +P  + +      L    
Sbjct: 356 WEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNP 415

Query: 366 KYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIV 425
            ++  P  F P R+    S+ +     HP+A  PF  G+R+CIG+  A +E +  ++  +
Sbjct: 416 YFWEDPQVFNPLRFSRENSEKI-----HPYAFIPFSAGLRNCIGQHFAIIECKVAVALTL 470

Query: 426 ENFQVEWSGSSP 437
             F++    S P
Sbjct: 471 LRFKLAPDHSRP 482


>AL135960-6|CAI19734.1|  505|Homo sapiens cytochrome P450, family 4,
           subfamily Z, polypeptide 1 protein.
          Length = 505

 Score = 72.1 bits (169), Expect = 4e-12
 Identities = 85/372 (22%), Positives = 158/372 (42%), Gaps = 39/372 (10%)

Query: 92  GLVSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFD 151
           GLV+  G  WK  R  V P       ++++ + + E    M+ +      +N+R+  +  
Sbjct: 124 GLVTLDGSKWKKHRQIVKPGF-NISILKIFITMMSESVRMMLNKWEEHIAQNSRL--ELF 180

Query: 152 QEMNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNE-----LDLKPS 206
           Q ++L +L+SI   A  ++      ++Q DS +   ++ V  +  +SN+     L     
Sbjct: 181 QHVSLMTLDSIMKCAFSHQ-----GSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDL 235

Query: 207 IWTYVST-PLFRK-TMKMYEEQENLTKYFIKKALDDIKMNKSKSD--DEKPVL-----EK 257
           ++ + S   +F K   ++++  E + +   +   D +K + ++    D   +L     E 
Sbjct: 236 VFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSEN 295

Query: 258 LLDINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS--- 314
             D +E          + AG DTTS+ +S  LY +A   + QQ+ R+E+    G  S   
Sbjct: 296 TKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSIT 355

Query: 315 --------YLRACIKEAMRILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMME 365
                   Y   CIKE +R+   V    R   K      G  +P  + +      L    
Sbjct: 356 WEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNP 415

Query: 366 KYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIV 425
            ++  P  F P R+    S+ +     HP+A  PF  G+R+CIG+  A +E +  ++  +
Sbjct: 416 YFWEDPQVFNPLRFSRENSEKI-----HPYAFIPFSAGLRNCIGQHFAIIECKVAVALTL 470

Query: 426 ENFQVEWSGSSP 437
             F++    S P
Sbjct: 471 LRFKLAPDHSRP 482


>DQ211353-1|ABB01370.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score = 70.5 bits (165), Expect = 1e-11
 Identities = 49/198 (24%), Positives = 90/198 (45%), Gaps = 17/198 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 291 NDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 350

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 351 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 410

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 411 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465

Query: 430 VEWSGSSPRVEQTSINYF 447
              +   PR   + +  F
Sbjct: 466 FSVAAGQPRPSHSRVVSF 483


>BC035959-1|AAH35959.1|  503|Homo sapiens cytochrome P450, family
           19, subfamily A, polypeptide 1 protein.
          Length = 503

 Score = 69.3 bits (162), Expect = 3e-11
 Identities = 84/354 (23%), Positives = 154/354 (43%), Gaps = 40/354 (11%)

Query: 93  LVSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQ 152
           + +++ ELWK+ R      L  P  +R+ +   E + T + +RL  + +E+    G  D 
Sbjct: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHL-DRLEEVTNES----GYVDV 187

Query: 153 EMNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVS 212
                 L  +  V L      F     D+S +   +  +   F     L +KP I+  +S
Sbjct: 188 ------LTLLRRVMLDTSNTLFLRISLDESAI---VVKIQGYFDAWQALLIKPDIFFKIS 238

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDIKMNKSKSD-----DEKPVLEKLLDINEEYAY 267
             L++K  K  ++ ++  +  I +    I   +   +      E  + EK  D+  E   
Sbjct: 239 W-LYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVN 297

Query: 268 IMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRSY----------LR 317
               +ML+A  DT S ++   L+L+A + + ++ + +E+ +  G+R            + 
Sbjct: 298 QCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVME 357

Query: 318 ACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPE 377
             I E+MR  PVV   MR+  ++  I GY + +  +I      +  +E ++P+P EF  E
Sbjct: 358 NFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLE 416

Query: 378 RWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
            +  N   P  Y         PFGFG R C G+ IA + ++  L  ++  F V+
Sbjct: 417 NFAKNV--PYRYFQ-------PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVK 461


>Y07508-1|CAA68807.1|  503|Homo sapiens protein ( Human mRNA for
           aromatase P-450. ).
          Length = 503

 Score = 68.9 bits (161), Expect = 3e-11
 Identities = 84/354 (23%), Positives = 154/354 (43%), Gaps = 40/354 (11%)

Query: 93  LVSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQ 152
           + +++ ELWK+ R      L  P  +R+ +   E + T + +RL  + +E+    G  D 
Sbjct: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHL-DRLEEVTNES----GYVDV 187

Query: 153 EMNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVS 212
                 L  +  V L      F     D+S +   +  +   F     L +KP I+  +S
Sbjct: 188 ------LTLLRRVMLDTSNTLFLRIPLDESAI---VVKIQGYFDAWQALLIKPDIFFKIS 238

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDIKMNKSKSD-----DEKPVLEKLLDINEEYAY 267
             L++K  K  ++ ++  +  I +    I   +   +      E  + EK  D+  E   
Sbjct: 239 W-LYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVN 297

Query: 268 IMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRSY----------LR 317
               +ML+A  DT S ++   L+L+A + + ++ + +E+ +  G+R            + 
Sbjct: 298 QCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVME 357

Query: 318 ACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPE 377
             I E+MR  PVV   MR+  ++  I GY + +  +I      +  +E ++P+P EF  E
Sbjct: 358 NFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLE 416

Query: 378 RWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
            +  N   P  Y         PFGFG R C G+ IA + ++  L  ++  F V+
Sbjct: 417 NFAKNV--PYRYFQ-------PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVK 461


>X13589-1|CAA31929.1|  503|Homo sapiens protein ( Human mRNA for
           aromatase (estrogen synthetase). ).
          Length = 503

 Score = 68.9 bits (161), Expect = 3e-11
 Identities = 84/354 (23%), Positives = 154/354 (43%), Gaps = 40/354 (11%)

Query: 93  LVSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQ 152
           + +++ ELWK+ R      L  P  +R+ +   E + T + +RL  + +E+    G  D 
Sbjct: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHL-DRLEEVTNES----GYVDV 187

Query: 153 EMNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVS 212
                 L  +  V L      F     D+S +   +  +   F     L +KP I+  +S
Sbjct: 188 ------LTLLRRVMLDTSNTLFLRIPLDESAI---VVKIQGYFDAWQALLIKPDIFFKIS 238

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDIKMNKSKSD-----DEKPVLEKLLDINEEYAY 267
             L++K  K  ++ ++  +  I +    I   +   +      E  + EK  D+  E   
Sbjct: 239 W-LYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVN 297

Query: 268 IMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRSY----------LR 317
               +ML+A  DT S ++   L+L+A + + ++ + +E+ +  G+R            + 
Sbjct: 298 QCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVME 357

Query: 318 ACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPE 377
             I E+MR  PVV   MR+  ++  I GY + +  +I      +  +E ++P+P EF  E
Sbjct: 358 NFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLE 416

Query: 378 RWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
            +  N   P  Y         PFGFG R C G+ IA + ++  L  ++  F V+
Sbjct: 417 NFAKNV--PYRYFQ-------PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVK 461


>M30804-1|AAA35728.1|  503|Homo sapiens protein ( Human aromatase
           cytochrome P-450 gene, exon 10. ).
          Length = 503

 Score = 68.9 bits (161), Expect = 3e-11
 Identities = 84/354 (23%), Positives = 154/354 (43%), Gaps = 40/354 (11%)

Query: 93  LVSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQ 152
           + +++ ELWK+ R      L  P  +R+ +   E + T + +RL  + +E+    G  D 
Sbjct: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHL-DRLEEVTNES----GYVDV 187

Query: 153 EMNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVS 212
                 L  +  V L      F     D+S +   +  +   F     L +KP I+  +S
Sbjct: 188 ------LTLLRRVMLDTSNTLFLRIPLDESAI---VVKIQGYFDAWQALLIKPDIFFKIS 238

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDIKMNKSKSD-----DEKPVLEKLLDINEEYAY 267
             L++K  K  ++ ++  +  I +    I   +   +      E  + EK  D+  E   
Sbjct: 239 W-LYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVN 297

Query: 268 IMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRSY----------LR 317
               +ML+A  DT S ++   L+L+A + + ++ + +E+ +  G+R            + 
Sbjct: 298 QCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVME 357

Query: 318 ACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPE 377
             I E+MR  PVV   MR+  ++  I GY + +  +I      +  +E ++P+P EF  E
Sbjct: 358 NFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLE 416

Query: 378 RWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
            +  N   P  Y         PFGFG R C G+ IA + ++  L  ++  F V+
Sbjct: 417 NFAKNV--PYRYFQ-------PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVK 461


>M22246-1|AAA35557.1|  503|Homo sapiens protein ( Human aromatase
           mRNA, complete cds. ).
          Length = 503

 Score = 68.9 bits (161), Expect = 3e-11
 Identities = 84/354 (23%), Positives = 154/354 (43%), Gaps = 40/354 (11%)

Query: 93  LVSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQ 152
           + +++ ELWK+ R      L  P  +R+ +   E + T + +RL  + +E+    G  D 
Sbjct: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHL-DRLEEVTNES----GYVDV 187

Query: 153 EMNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVS 212
                 L  +  V L      F     D+S +   +  +   F     L +KP I+  +S
Sbjct: 188 ------LTLLRRVMLDTSNTLFLRIPLDESAI---VVKIQGYFDAWQALLIKPDIFFKIS 238

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDIKMNKSKSD-----DEKPVLEKLLDINEEYAY 267
             L++K  K  ++ ++  +  I +    I   +   +      E  + EK  D+  E   
Sbjct: 239 W-LYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVN 297

Query: 268 IMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRSY----------LR 317
               +ML+A  DT S ++   L+L+A + + ++ + +E+ +  G+R            + 
Sbjct: 298 QCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVME 357

Query: 318 ACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPE 377
             I E+MR  PVV   MR+  ++  I GY + +  +I      +  +E ++P+P EF  E
Sbjct: 358 NFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLE 416

Query: 378 RWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
            +  N   P  Y         PFGFG R C G+ IA + ++  L  ++  F V+
Sbjct: 417 NFAKNV--PYRYFQ-------PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVK 461


>M18856-1|AAA35556.1|  419|Homo sapiens protein ( Human aromatase
           (Aro1) mRNA, complete cds. ).
          Length = 419

 Score = 68.9 bits (161), Expect = 3e-11
 Identities = 84/354 (23%), Positives = 154/354 (43%), Gaps = 40/354 (11%)

Query: 93  LVSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQ 152
           + +++ ELWK+ R      L  P  +R+ +   E + T + +RL  + +E+    G  D 
Sbjct: 49  IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHL-DRLEEVTNES----GYVDV 103

Query: 153 EMNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVS 212
                 L  +  V L      F     D+S +   +  +   F     L +KP I+  +S
Sbjct: 104 ------LTLLRRVMLDTSNTLFLRIPLDESAI---VVKIQGYFDAWQALLIKPDIFFKIS 154

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDIKMNKSKSD-----DEKPVLEKLLDINEEYAY 267
             L++K  K  ++ ++  +  I +    I   +   +      E  + EK  D+  E   
Sbjct: 155 W-LYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVN 213

Query: 268 IMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRSY----------LR 317
               +ML+A  DT S ++   L+L+A + + ++ + +E+ +  G+R            + 
Sbjct: 214 QCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVME 273

Query: 318 ACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPE 377
             I E+MR  PVV   MR+  ++  I GY + +  +I      +  +E ++P+P EF  E
Sbjct: 274 NFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLE 332

Query: 378 RWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
            +  N   P  Y         PFGFG R C G+ IA + ++  L  ++  F V+
Sbjct: 333 NFAKNV--PYRYFQ-------PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVK 377


>DQ118405-1|AAZ23558.1|  503|Homo sapiens cytochrome P450 subfamily
           19 subfamily A polypeptide 1 protein.
          Length = 503

 Score = 68.9 bits (161), Expect = 3e-11
 Identities = 84/354 (23%), Positives = 154/354 (43%), Gaps = 40/354 (11%)

Query: 93  LVSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQ 152
           + +++ ELWK+ R      L  P  +R+ +   E + T + +RL  + +E+    G  D 
Sbjct: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHL-DRLEEVTNES----GYVDV 187

Query: 153 EMNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVS 212
                 L  +  V L      F     D+S +   +  +   F     L +KP I+  +S
Sbjct: 188 ------LTLLRRVMLDTSNTLFLRIPLDESAI---VVKIQGYFDAWQALLIKPDIFFKIS 238

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDIKMNKSKSD-----DEKPVLEKLLDINEEYAY 267
             L++K  K  ++ ++  +  I +    I   +   +      E  + EK  D+  E   
Sbjct: 239 W-LYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVN 297

Query: 268 IMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRSY----------LR 317
               +ML+A  DT S ++   L+L+A + + ++ + +E+ +  G+R            + 
Sbjct: 298 QCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVME 357

Query: 318 ACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPE 377
             I E+MR  PVV   MR+  ++  I GY + +  +I      +  +E ++P+P EF  E
Sbjct: 358 NFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLE 416

Query: 378 RWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
            +  N   P  Y         PFGFG R C G+ IA + ++  L  ++  F V+
Sbjct: 417 NFAKNV--PYRYFQ-------PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVK 461


>AY957953-1|AAX44046.1|  503|Homo sapiens cytochrome P450, family
           19, subfamily A, polypeptide 1 protein.
          Length = 503

 Score = 68.9 bits (161), Expect = 3e-11
 Identities = 84/354 (23%), Positives = 154/354 (43%), Gaps = 40/354 (11%)

Query: 93  LVSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQ 152
           + +++ ELWK+ R      L  P  +R+ +   E + T + +RL  + +E+    G  D 
Sbjct: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHL-DRLEEVTNES----GYVDV 187

Query: 153 EMNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVS 212
                 L  +  V L      F     D+S +   +  +   F     L +KP I+  +S
Sbjct: 188 ------LTLLRRVMLDTSNTLFLRIPLDESAI---VVKIQGYFDAWQALLIKPDIFFKIS 238

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDIKMNKSKSD-----DEKPVLEKLLDINEEYAY 267
             L++K  K  ++ ++  +  I +    I   +   +      E  + EK  D+  E   
Sbjct: 239 W-LYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVN 297

Query: 268 IMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRSY----------LR 317
               +ML+A  DT S ++   L+L+A + + ++ + +E+ +  G+R            + 
Sbjct: 298 QCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVME 357

Query: 318 ACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPE 377
             I E+MR  PVV   MR+  ++  I GY + +  +I      +  +E ++P+P EF  E
Sbjct: 358 NFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLE 416

Query: 378 RWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
            +  N   P  Y         PFGFG R C G+ IA + ++  L  ++  F V+
Sbjct: 417 NFAKNV--PYRYFQ-------PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVK 461


>X08006-1|CAA30807.1|  497|Homo sapiens cytochrome P450 db1 protein.
          Length = 497

 Score = 68.5 bits (160), Expect = 5e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 291 NDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 350

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 351 AHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 410

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 411 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 466 FSVPTGQPR 474


>M28420-1|AAA52141.1|  419|Homo sapiens cytochrome P-450 aromatase
           protein.
          Length = 419

 Score = 68.5 bits (160), Expect = 5e-11
 Identities = 84/354 (23%), Positives = 154/354 (43%), Gaps = 40/354 (11%)

Query: 93  LVSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQ 152
           + +++ ELWK+ R      L  P  +R+ +   E + T + +RL  + +E+    G  D 
Sbjct: 49  IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHL-DRLEEVTNES----GYVDV 103

Query: 153 EMNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVS 212
                 L  +  V L      F     D+S +   +  +   F     L +KP I+  +S
Sbjct: 104 ------LTLLRRVMLDTSNTLFLRIPLDESAI---VVKIQGYFDAWQALLIKPDIFFKIS 154

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDIKMNKSKSD-----DEKPVLEKLLDINEEYAY 267
             L++K  K  ++ ++  +  I +    I   +   +      E  + EK  D+  E   
Sbjct: 155 W-LYKKYEKSVKDLKDAIEVLIAEKRCRISTEEKLEECMDFATELILAEKRGDLTRENVN 213

Query: 268 IMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRSY----------LR 317
               +ML+A  DT S ++   L+L+A + + ++ + +E+ +  G+R            + 
Sbjct: 214 QCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVME 273

Query: 318 ACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPE 377
             I E+MR  PVV   MR+  ++  I GY + +  +I      +  +E ++P+P EF  E
Sbjct: 274 NFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLE 332

Query: 378 RWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
            +  N   P  Y         PFGFG R C G+ IA + ++  L  ++  F V+
Sbjct: 333 NFAKNV--PYRYFQ-------PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVK 377


>M20403-1|AAA52153.1|  497|Homo sapiens CYP2D protein.
          Length = 497

 Score = 68.5 bits (160), Expect = 5e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 291 NDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 350

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 351 AHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 410

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 411 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 466 FSVPTGQPR 474


>J04127-1|AAA52132.1|  503|Homo sapiens CYP19 protein.
          Length = 503

 Score = 68.5 bits (160), Expect = 5e-11
 Identities = 84/354 (23%), Positives = 154/354 (43%), Gaps = 40/354 (11%)

Query: 93  LVSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQ 152
           + +++ ELWK+ R      L  P  +R+ +   E + T + +RL  + +E+    G  D 
Sbjct: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHL-DRLEEVTNES----GYVDV 187

Query: 153 EMNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVS 212
                 L  +  V L      F     D+S +   +  +   F     L +KP I+  +S
Sbjct: 188 ------LTLLRRVMLDTSNTLFLRIPLDESAI---VVKIQGYFDAWQALLIKPDIFFKIS 238

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDIKMNKSKSD-----DEKPVLEKLLDINEEYAY 267
             L++K  K  ++ ++  +  I +    I   +   +      E  + EK  D+  E   
Sbjct: 239 W-LYKKYEKSVKDLKDAIEVLIAEKRCRISTEEKLEECMDFATELILAEKRGDLTRENVN 297

Query: 268 IMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRSY----------LR 317
               +ML+A  DT S ++   L+L+A + + ++ + +E+ +  G+R            + 
Sbjct: 298 QCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVME 357

Query: 318 ACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPE 377
             I E+MR  PVV   MR+  ++  I GY + +  +I      +  +E ++P+P EF  E
Sbjct: 358 NFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLE 416

Query: 378 RWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
            +  N   P  Y         PFGFG R C G+ IA + ++  L  ++  F V+
Sbjct: 417 NFAKNV--PYRYFQ-------PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVK 461


>M33388-1|AAA53500.1|  497|Homo sapiens cytochrome P450 IID6
           protein.
          Length = 497

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 291 NDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 350

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 351 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 410

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 411 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 466 FSVPTGQPR 474


>M33189-1|AAA35737.1|  500|Homo sapiens protein ( Human debrisoquine
           4-hydroxylase mutant allele (CYP2D6-MA1) gene, complete
           cds. ).
          Length = 500

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 294 NDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 353

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 354 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 413

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 414 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 468

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 469 FSVPTGQPR 477


>M24499-1|AAA36403.1|  373|Homo sapiens cytochrome P450db1 protein.
          Length = 373

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 167 NDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 226

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 227 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 286

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 287 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 341

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 342 FSVPTGQPR 350


>DQ282162-1|ABB77909.1|  500|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 500

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 294 NDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 353

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 354 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 413

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 414 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 468

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 469 FSVPTGQPR 477


>DQ282160-1|ABB77908.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 291 NDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 350

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 351 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 410

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 411 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 466 FSVPTGQPR 474


>DQ282159-1|ABB77907.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 291 NDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 350

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 351 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 410

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 411 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 466 FSVPTGQPR 474


>DQ282158-1|ABB77906.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 291 NDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 350

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 351 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 410

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 411 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 466 FSVPTGQPR 474


>DQ282157-1|ABB77905.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 291 NDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 350

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 351 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 410

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 411 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 466 FSVPTGQPR 474


>DQ282156-1|ABB77904.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 291 NDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 350

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 351 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 410

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 411 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 466 FSVPTGQPR 474


>DQ282155-1|ABB77903.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 291 NDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 350

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 351 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 410

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 411 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 466 FSVPTGQPR 474


>DQ282154-1|ABB77902.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 291 NDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 350

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 351 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 410

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 411 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 466 FSVPTGQPR 474


>DQ282153-1|ABB77901.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 291 NDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDMIGQVRRPEMGDQ 350

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 351 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 410

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 411 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 466 FSVPTGQPR 474


>DQ282152-1|ABB77900.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 291 NDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 350

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 351 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 410

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 411 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 466 FSVPTGQPR 474


>DQ282151-1|ABB77899.1|  496|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 496

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 290 NDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 349

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 350 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 409

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 410 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 464

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 465 FSVPTGQPR 473


>DQ282147-1|ABB77898.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 291 NDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 350

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 351 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 410

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 411 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 466 FSVPTGQPR 474


>DQ282146-1|ABB77897.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 291 NDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 350

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 351 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 410

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 411 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 466 FSVPTGQPR 474


>DQ282145-1|ABB77896.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 291 NDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 350

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 351 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 410

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 411 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 466 FSVPTGQPR 474


>DQ282144-1|ABB77895.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 291 NDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 350

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 351 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 410

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 411 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 466 FSVPTGQPR 474


>DQ211354-2|ABB01372.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 291 NDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 350

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 351 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 410

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 411 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 466 FSVPTGQPR 474


>DQ211353-2|ABB01371.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 291 NDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 350

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 351 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 410

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 411 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 466 FSVPTGQPR 474


>CR456430-1|CAG30316.1|  446|Homo sapiens CYP2D6 protein.
          Length = 446

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 240 NDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 299

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 300 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 359

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 360 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 414

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 415 FSVPTGQPR 423


>BC126858-1|AAI26859.1|  497|Homo sapiens cytochrome P450, family 2,
           subfamily D, polypeptide 6 protein.
          Length = 497

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 291 NDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 350

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 351 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 410

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 411 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 466 FSVPTGQPR 474


>BC107785-1|AAI07786.1|  503|Homo sapiens cytochrome P450, family
           19, subfamily A, polypeptide 1 protein.
          Length = 503

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 84/354 (23%), Positives = 154/354 (43%), Gaps = 40/354 (11%)

Query: 93  LVSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQFDQ 152
           + +++ ELWK+ R      L  P  +R+ +   E + T + +RL  + +E+    G  D 
Sbjct: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHL-DRLEEVTNES----GYVDV 187

Query: 153 EMNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVS 212
                 L  +  V L      F     D+S +   +  +   F     L +KP I+  +S
Sbjct: 188 ------LTLLRRVMLDTSNMLFLRIPLDESAI---VVKIQGYFDAWQALLIKPDIFFKIS 238

Query: 213 TPLFRKTMKMYEEQENLTKYFIKKALDDIKMNKSKSD-----DEKPVLEKLLDINEEYAY 267
             L++K  K  ++ ++  +  I +    I   +   +      E  + EK  D+  E   
Sbjct: 239 W-LYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVN 297

Query: 268 IMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRSY----------LR 317
               +ML+A  DT S ++   L+L+A + + ++ + +E+ +  G+R            + 
Sbjct: 298 QCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVME 357

Query: 318 ACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPE 377
             I E+MR  PVV   MR+  ++  I GY + +  +I      +  +E ++P+P EF  E
Sbjct: 358 NFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLE 416

Query: 378 RWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
            +  N   P  Y         PFGFG R C G+ IA + ++  L  ++  F V+
Sbjct: 417 NFAKNV--PYRYFQ-------PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVK 461


>BC106758-1|AAI06759.1|  497|Homo sapiens cytochrome P450, family 2,
           subfamily D, polypeptide 6 protein.
          Length = 497

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 291 NDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDEVIGQVRRPEMGDQ 350

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 351 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 410

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 411 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 466 FSVPTGQPR 474


>BC106757-1|AAI06758.1|  446|Homo sapiens cytochrome P450, family 2,
           subfamily D, polypeptide 6 protein.
          Length = 446

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 240 NDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 299

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 300 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 359

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 360 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 414

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 415 FSVPTGQPR 423


>BC075024-1|AAH75024.1|  497|Homo sapiens cytochrome P450, family 2,
           subfamily D, polypeptide 6 protein.
          Length = 497

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 291 NDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 350

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 351 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 410

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 411 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 466 FSVPTGQPR 474


>BC075023-1|AAH75023.1|  497|Homo sapiens cytochrome P450, family 2,
           subfamily D, polypeptide 6 protein.
          Length = 497

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 291 NDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 350

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 351 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 410

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 411 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 466 FSVPTGQPR 474


>BC067432-1|AAH67432.1|  497|Homo sapiens cytochrome P450, family 2,
           subfamily D, polypeptide 6 protein.
          Length = 497

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 291 NDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 350

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 351 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 410

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 411 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 466 FSVPTGQPR 474


>BC066877-1|AAH66877.1|  446|Homo sapiens CYP2D6 protein protein.
          Length = 446

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 240 NDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 299

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 300 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 359

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 360 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 414

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 415 FSVPTGQPR 423


>AY545216-1|AAS55001.1|  497|Homo sapiens cytochrome P4502D6
           protein.
          Length = 497

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 291 NDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 350

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 351 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 410

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 411 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 466 FSVPTGQPR 474


>AB209492-1|BAD92729.1|  566|Homo sapiens Debrisoquine 4-hydroxylase
           mutant allele variant protein.
          Length = 566

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKN 310
           N+E   I+ +D+  AG+ TTS T++  L LM ++ D Q+++++E+           M   
Sbjct: 360 NDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 419

Query: 311 GKRSYLRACIKEAMRILPVVS-GNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R   +V  G    T+++  + G+ IP+   +      +   E  + 
Sbjct: 420 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 479

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           +P  F PE +L  +          P A  PF  G R+C+G  +A +E+  F + ++++F 
Sbjct: 480 KPFRFHPEHFLDAQGH-----FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 534

Query: 430 VEWSGSSPR 438
                  PR
Sbjct: 535 FSVPTGQPR 543


>M63871-1|AAA59984.1|  508|Homo sapiens CYP17 protein.
          Length = 508

 Score = 67.7 bits (158), Expect = 8e-11
 Identities = 61/276 (22%), Positives = 122/276 (44%), Gaps = 18/276 (6%)

Query: 169 NRLNCFDSNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVSTPLFRKTMKMYEEQEN 228
           N +  ++  + D+     L++ V  + +  N+   K      +   L  K ++ Y+E+  
Sbjct: 196 NVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFR 255

Query: 229 LTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDI-NEEYAYIMASDMLVAGVDTTSNTMSA 287
                I   LD +   K  SD+     ++  ++ ++ +      D+  AGV+TT++ +  
Sbjct: 256 SDS--ITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKW 313

Query: 288 TLYLMAINQDKQQKLREEV-----------MSKNGKRSYLRACIKEAMRILPVVSGNMRR 336
           TL  +  N   ++KL EE+           +S   +   L A I+E +R+ PV    +  
Sbjct: 314 TLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPH 373

Query: 337 TTKEYNILG-YHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPF 395
                + +G + + +  ++      L   EK + +P +F+PER+L      L   +    
Sbjct: 374 KANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSV--- 430

Query: 396 ANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
           +  PFG G RSCIG  +A  E+   ++ +++ F +E
Sbjct: 431 SYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466


>M31153-1|AAA52140.1|  508|Homo sapiens CYP17 protein.
          Length = 508

 Score = 67.7 bits (158), Expect = 8e-11
 Identities = 61/276 (22%), Positives = 122/276 (44%), Gaps = 18/276 (6%)

Query: 169 NRLNCFDSNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVSTPLFRKTMKMYEEQEN 228
           N +  ++  + D+     L++ V  + +  N+   K      +   L  K ++ Y+E+  
Sbjct: 196 NVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFR 255

Query: 229 LTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDI-NEEYAYIMASDMLVAGVDTTSNTMSA 287
                I   LD +   K  SD+     ++  ++ ++ +      D+  AGV+TT++ +  
Sbjct: 256 SDS--ITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKW 313

Query: 288 TLYLMAINQDKQQKLREEV-----------MSKNGKRSYLRACIKEAMRILPVVSGNMRR 336
           TL  +  N   ++KL EE+           +S   +   L A I+E +R+ PV    +  
Sbjct: 314 TLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPH 373

Query: 337 TTKEYNILG-YHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPF 395
                + +G + + +  ++      L   EK + +P +F+PER+L      L   +    
Sbjct: 374 KANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSV--- 430

Query: 396 ANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
           +  PFG G RSCIG  +A  E+   ++ +++ F +E
Sbjct: 431 SYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466


>M19489-1|AAA36405.1|  508|Homo sapiens CYP17 protein.
          Length = 508

 Score = 67.7 bits (158), Expect = 8e-11
 Identities = 61/276 (22%), Positives = 122/276 (44%), Gaps = 18/276 (6%)

Query: 169 NRLNCFDSNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVSTPLFRKTMKMYEEQEN 228
           N +  ++  + D+     L++ V  + +  N+   K      +   L  K ++ Y+E+  
Sbjct: 196 NVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFR 255

Query: 229 LTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDI-NEEYAYIMASDMLVAGVDTTSNTMSA 287
                I   LD +   K  SD+     ++  ++ ++ +      D+  AGV+TT++ +  
Sbjct: 256 SDS--ITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKW 313

Query: 288 TLYLMAINQDKQQKLREEV-----------MSKNGKRSYLRACIKEAMRILPVVSGNMRR 336
           TL  +  N   ++KL EE+           +S   +   L A I+E +R+ PV    +  
Sbjct: 314 TLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPH 373

Query: 337 TTKEYNILG-YHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPF 395
                + +G + + +  ++      L   EK + +P +F+PER+L      L   +    
Sbjct: 374 KANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSV--- 430

Query: 396 ANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
           +  PFG G RSCIG  +A  E+   ++ +++ F +E
Sbjct: 431 SYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466


>M14564-1|AAA52151.1|  508|Homo sapiens CYP17 protein.
          Length = 508

 Score = 67.7 bits (158), Expect = 8e-11
 Identities = 61/276 (22%), Positives = 122/276 (44%), Gaps = 18/276 (6%)

Query: 169 NRLNCFDSNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVSTPLFRKTMKMYEEQEN 228
           N +  ++  + D+     L++ V  + +  N+   K      +   L  K ++ Y+E+  
Sbjct: 196 NVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFR 255

Query: 229 LTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDI-NEEYAYIMASDMLVAGVDTTSNTMSA 287
                I   LD +   K  SD+     ++  ++ ++ +      D+  AGV+TT++ +  
Sbjct: 256 SDS--ITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKW 313

Query: 288 TLYLMAINQDKQQKLREEV-----------MSKNGKRSYLRACIKEAMRILPVVSGNMRR 336
           TL  +  N   ++KL EE+           +S   +   L A I+E +R+ PV    +  
Sbjct: 314 TLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPH 373

Query: 337 TTKEYNILG-YHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPF 395
                + +G + + +  ++      L   EK + +P +F+PER+L      L   +    
Sbjct: 374 KANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSV--- 430

Query: 396 ANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
           +  PFG G RSCIG  +A  E+   ++ +++ F +E
Sbjct: 431 SYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466


>DQ530598-1|ABF50972.1|  508|Homo sapiens cytochrome P450, family
           17, subfamily A, polypeptide 1 protein.
          Length = 508

 Score = 67.7 bits (158), Expect = 8e-11
 Identities = 61/276 (22%), Positives = 122/276 (44%), Gaps = 18/276 (6%)

Query: 169 NRLNCFDSNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVSTPLFRKTMKMYEEQEN 228
           N +  ++  + D+     L++ V  + +  N+   K      +   L  K ++ Y+E+  
Sbjct: 196 NVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFR 255

Query: 229 LTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDI-NEEYAYIMASDMLVAGVDTTSNTMSA 287
                I   LD +   K  SD+     ++  ++ ++ +      D+  AGV+TT++ +  
Sbjct: 256 SDS--ITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKW 313

Query: 288 TLYLMAINQDKQQKLREEV-----------MSKNGKRSYLRACIKEAMRILPVVSGNMRR 336
           TL  +  N   ++KL EE+           +S   +   L A I+E +R+ PV    +  
Sbjct: 314 TLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPH 373

Query: 337 TTKEYNILG-YHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPF 395
                + +G + + +  ++      L   EK + +P +F+PER+L      L   +    
Sbjct: 374 KANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSV--- 430

Query: 396 ANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
           +  PFG G RSCIG  +A  E+   ++ +++ F +E
Sbjct: 431 SYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466


>BT020000-1|AAV38803.1|  508|Homo sapiens cytochrome P450, family
           17, subfamily A, polypeptide 1 protein.
          Length = 508

 Score = 67.7 bits (158), Expect = 8e-11
 Identities = 61/276 (22%), Positives = 122/276 (44%), Gaps = 18/276 (6%)

Query: 169 NRLNCFDSNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVSTPLFRKTMKMYEEQEN 228
           N +  ++  + D+     L++ V  + +  N+   K      +   L  K ++ Y+E+  
Sbjct: 196 NVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFR 255

Query: 229 LTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDI-NEEYAYIMASDMLVAGVDTTSNTMSA 287
                I   LD +   K  SD+     ++  ++ ++ +      D+  AGV+TT++ +  
Sbjct: 256 SDS--ITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKW 313

Query: 288 TLYLMAINQDKQQKLREEV-----------MSKNGKRSYLRACIKEAMRILPVVSGNMRR 336
           TL  +  N   ++KL EE+           +S   +   L A I+E +R+ PV    +  
Sbjct: 314 TLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPH 373

Query: 337 TTKEYNILG-YHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPF 395
                + +G + + +  ++      L   EK + +P +F+PER+L      L   +    
Sbjct: 374 KANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSV--- 430

Query: 396 ANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
           +  PFG G RSCIG  +A  E+   ++ +++ F +E
Sbjct: 431 SYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466


>BC063388-1|AAH63388.1|  508|Homo sapiens cytochrome P450, family
           17, subfamily A, polypeptide 1 protein.
          Length = 508

 Score = 67.7 bits (158), Expect = 8e-11
 Identities = 61/276 (22%), Positives = 122/276 (44%), Gaps = 18/276 (6%)

Query: 169 NRLNCFDSNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVSTPLFRKTMKMYEEQEN 228
           N +  ++  + D+     L++ V  + +  N+   K      +   L  K ++ Y+E+  
Sbjct: 196 NVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFR 255

Query: 229 LTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDI-NEEYAYIMASDMLVAGVDTTSNTMSA 287
                I   LD +   K  SD+     ++  ++ ++ +      D+  AGV+TT++ +  
Sbjct: 256 SDS--ITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKW 313

Query: 288 TLYLMAINQDKQQKLREEV-----------MSKNGKRSYLRACIKEAMRILPVVSGNMRR 336
           TL  +  N   ++KL EE+           +S   +   L A I+E +R+ PV    +  
Sbjct: 314 TLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPH 373

Query: 337 TTKEYNILG-YHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPF 395
                + +G + + +  ++      L   EK + +P +F+PER+L      L   +    
Sbjct: 374 KANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSV--- 430

Query: 396 ANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
           +  PFG G RSCIG  +A  E+   ++ +++ F +E
Sbjct: 431 SYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466


>BC062997-1|AAH62997.1|  508|Homo sapiens cytochrome P450, family
           17, subfamily A, polypeptide 1 protein.
          Length = 508

 Score = 67.7 bits (158), Expect = 8e-11
 Identities = 61/276 (22%), Positives = 122/276 (44%), Gaps = 18/276 (6%)

Query: 169 NRLNCFDSNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVSTPLFRKTMKMYEEQEN 228
           N +  ++  + D+     L++ V  + +  N+   K      +   L  K ++ Y+E+  
Sbjct: 196 NVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFR 255

Query: 229 LTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDI-NEEYAYIMASDMLVAGVDTTSNTMSA 287
                I   LD +   K  SD+     ++  ++ ++ +      D+  AGV+TT++ +  
Sbjct: 256 SDS--ITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKW 313

Query: 288 TLYLMAINQDKQQKLREEV-----------MSKNGKRSYLRACIKEAMRILPVVSGNMRR 336
           TL  +  N   ++KL EE+           +S   +   L A I+E +R+ PV    +  
Sbjct: 314 TLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPH 373

Query: 337 TTKEYNILG-YHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPF 395
                + +G + + +  ++      L   EK + +P +F+PER+L      L   +    
Sbjct: 374 KANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSV--- 430

Query: 396 ANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
           +  PFG G RSCIG  +A  E+   ++ +++ F +E
Sbjct: 431 SYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466


>BC022539-1|AAH22539.1|  500|Homo sapiens cytochrome P450, family
           46, subfamily A, polypeptide 1 protein.
          Length = 500

 Score = 67.7 bits (158), Expect = 8e-11
 Identities = 45/166 (27%), Positives = 82/166 (49%), Gaps = 18/166 (10%)

Query: 275 VAGVDTTSNTMSATLYLMAINQDKQQKLREEVM----SKN-------GKRSYLRACIKEA 323
           +AG +T++N ++ T+  ++   +   +L+ EV     SK        G+  YL   +KE+
Sbjct: 301 IAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKES 360

Query: 324 MRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNK 383
           +R+ P   G  R   +E  I G  +P N  + F+   +  M+ Y+  P  F P+R+    
Sbjct: 361 LRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGA 420

Query: 384 SDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
             P        F   PF  G RSCIG++ A++EV+  ++K+++  +
Sbjct: 421 PKP-------RFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE 459


>AL358790-3|CAI52498.1|  508|Homo sapiens cytochrome P450, family
           17, subfamily A, polypeptide 1 protein.
          Length = 508

 Score = 67.7 bits (158), Expect = 8e-11
 Identities = 61/276 (22%), Positives = 122/276 (44%), Gaps = 18/276 (6%)

Query: 169 NRLNCFDSNLQDDSPVKRLIECVHQMFVLSNELDLKPSIWTYVSTPLFRKTMKMYEEQEN 228
           N +  ++  + D+     L++ V  + +  N+   K      +   L  K ++ Y+E+  
Sbjct: 196 NVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFR 255

Query: 229 LTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDI-NEEYAYIMASDMLVAGVDTTSNTMSA 287
                I   LD +   K  SD+     ++  ++ ++ +      D+  AGV+TT++ +  
Sbjct: 256 SDS--ITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKW 313

Query: 288 TLYLMAINQDKQQKLREEV-----------MSKNGKRSYLRACIKEAMRILPVVSGNMRR 336
           TL  +  N   ++KL EE+           +S   +   L A I+E +R+ PV    +  
Sbjct: 314 TLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPH 373

Query: 337 TTKEYNILG-YHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPF 395
                + +G + + +  ++      L   EK + +P +F+PER+L      L   +    
Sbjct: 374 KANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSV--- 430

Query: 396 ANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
           +  PFG G RSCIG  +A  E+   ++ +++ F +E
Sbjct: 431 SYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466


>AF094480-1|AAD41244.1|  500|Homo sapiens cholesterol 24-hydroxylase
           protein.
          Length = 500

 Score = 67.7 bits (158), Expect = 8e-11
 Identities = 45/166 (27%), Positives = 82/166 (49%), Gaps = 18/166 (10%)

Query: 275 VAGVDTTSNTMSATLYLMAINQDKQQKLREEVM----SKN-------GKRSYLRACIKEA 323
           +AG +T++N ++ T+  ++   +   +L+ EV     SK        G+  YL   +KE+
Sbjct: 301 IAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKES 360

Query: 324 MRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNK 383
           +R+ P   G  R   +E  I G  +P N  + F+   +  M+ Y+  P  F P+R+    
Sbjct: 361 LRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGA 420

Query: 384 SDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
             P        F   PF  G RSCIG++ A++EV+  ++K+++  +
Sbjct: 421 PKP-------RFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE 459


>AL358613-1|CAH72802.2|  522|Homo sapiens cytochrome P450, family
           26, subfamily C, polypeptide 1 protein.
          Length = 522

 Score = 65.3 bits (152), Expect = 4e-10
 Identities = 37/128 (28%), Positives = 63/128 (49%), Gaps = 5/128 (3%)

Query: 311 GKRSYLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPR 370
           G+  Y+   +KE +R+LP VSG  R   + + + GY IP+   + ++ +        Y  
Sbjct: 364 GRLRYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSVMYSIRDTHETAAVYRS 423

Query: 371 PTE-FIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           P E F PER+   + D    G +  F   PFG G RSC+G+ +A+  ++    ++V    
Sbjct: 424 PPEGFDPERFGAAREDS--RGASSRFHYIPFGGGARSCLGQELAQAVLQLLAVELVRT-- 479

Query: 430 VEWSGSSP 437
             W  ++P
Sbjct: 480 ARWELATP 487


>X16699-1|CAA34672.1|  511|Homo sapiens protein ( Human mRNA for
           cytochrome P-450HP. ).
          Length = 511

 Score = 64.9 bits (151), Expect = 6e-10
 Identities = 50/165 (30%), Positives = 75/165 (45%), Gaps = 17/165 (10%)

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMS-----------KNGKRSYLRACIKEAMR 325
           G DTT++ +S  LY MA+  + Q + REEV               GK +YL  CIKE+ R
Sbjct: 316 GHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFR 375

Query: 326 ILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           + P V    R+ +K    + G  +P    I+     L      +P P  F   R+ T  +
Sbjct: 376 LYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENA 435

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
                   HPFA  PF  G R+CIG++ A  E++   +  +  F+
Sbjct: 436 S-----KRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 475


>J02871-1|AAA35712.1|  511|Homo sapiens protein ( Human lung
           cytochrome P450 (IV subfamily) BI protein, complete cds.
           ).
          Length = 511

 Score = 64.9 bits (151), Expect = 6e-10
 Identities = 50/165 (30%), Positives = 75/165 (45%), Gaps = 17/165 (10%)

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMS-----------KNGKRSYLRACIKEAMR 325
           G DTT++ +S  LY MA+  + Q + REEV               GK +YL  CIKE+ R
Sbjct: 316 GHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFR 375

Query: 326 ILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           + P V    R+ +K    + G  +P    I+     L      +P P  F   R+ T  +
Sbjct: 376 LYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENA 435

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
                   HPFA  PF  G R+CIG++ A  E++   +  +  F+
Sbjct: 436 S-----KRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 475


>DQ518907-1|ABF47106.1|  511|Homo sapiens cytochrome P450, family 4,
           subfamily B, polypeptide 1 protein.
          Length = 511

 Score = 64.9 bits (151), Expect = 6e-10
 Identities = 50/165 (30%), Positives = 75/165 (45%), Gaps = 17/165 (10%)

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMS-----------KNGKRSYLRACIKEAMR 325
           G DTT++ +S  LY MA+  + Q + REEV               GK +YL  CIKE+ R
Sbjct: 316 GHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFR 375

Query: 326 ILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           + P V    R+ +K    + G  +P    I+     L      +P P  F   R+ T  +
Sbjct: 376 LYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENA 435

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
                   HPFA  PF  G R+CIG++ A  E++   +  +  F+
Sbjct: 436 S-----KRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 475


>BC017758-1|AAH17758.1|  512|Homo sapiens cytochrome P450, family 4,
           subfamily B, polypeptide 1 protein.
          Length = 512

 Score = 64.9 bits (151), Expect = 6e-10
 Identities = 50/165 (30%), Positives = 75/165 (45%), Gaps = 17/165 (10%)

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMS-----------KNGKRSYLRACIKEAMR 325
           G DTT++ +S  LY MA+  + Q + REEV               GK +YL  CIKE+ R
Sbjct: 317 GHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFR 376

Query: 326 ILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           + P V    R+ +K    + G  +P    I+     L      +P P  F   R+ T  +
Sbjct: 377 LYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENA 436

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
                   HPFA  PF  G R+CIG++ A  E++   +  +  F+
Sbjct: 437 S-----KRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 476


>AY151049-1|AAN72312.1|  497|Homo sapiens pulmonary cytochrome P450
           4B1 variant protein.
          Length = 497

 Score = 64.9 bits (151), Expect = 6e-10
 Identities = 50/165 (30%), Positives = 75/165 (45%), Gaps = 17/165 (10%)

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMS-----------KNGKRSYLRACIKEAMR 325
           G DTT++ +S  LY MA+  + Q + REEV               GK +YL  CIKE+ R
Sbjct: 302 GHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFR 361

Query: 326 ILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           + P V    R+ +K    + G  +P    I+     L      +P P  F   R+ T  +
Sbjct: 362 LYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENA 421

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
                   HPFA  PF  G R+CIG++ A  E++   +  +  F+
Sbjct: 422 S-----KRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 461


>AY151048-1|AAN72311.1|  512|Homo sapiens pulmonary cytochrome P450
           4B1 protein.
          Length = 512

 Score = 64.9 bits (151), Expect = 6e-10
 Identities = 50/165 (30%), Positives = 75/165 (45%), Gaps = 17/165 (10%)

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMS-----------KNGKRSYLRACIKEAMR 325
           G DTT++ +S  LY MA+  + Q + REEV               GK +YL  CIKE+ R
Sbjct: 317 GHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFR 376

Query: 326 ILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           + P V    R+ +K    + G  +P    I+     L      +P P  F   R+ T  +
Sbjct: 377 LYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENA 436

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
                   HPFA  PF  G R+CIG++ A  E++   +  +  F+
Sbjct: 437 S-----KRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 476


>AY064485-1|AAL57720.1|  511|Homo sapiens cytochrome P450 protein.
          Length = 511

 Score = 64.9 bits (151), Expect = 6e-10
 Identities = 50/165 (30%), Positives = 75/165 (45%), Gaps = 17/165 (10%)

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMS-----------KNGKRSYLRACIKEAMR 325
           G DTT++ +S  LY MA+  + Q + REEV               GK +YL  CIKE+ R
Sbjct: 316 GHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFR 375

Query: 326 ILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           + P V    R+ +K    + G  +P    I+     L      +P P  F   R+ T  +
Sbjct: 376 LYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENA 435

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
                   HPFA  PF  G R+CIG++ A  E++   +  +  F+
Sbjct: 436 S-----KRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 475


>AL593856-7|CAI16983.1|  497|Homo sapiens cytochrome P450, family 4,
           subfamily B, polypeptide 1 protein.
          Length = 497

 Score = 64.9 bits (151), Expect = 6e-10
 Identities = 50/165 (30%), Positives = 75/165 (45%), Gaps = 17/165 (10%)

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMS-----------KNGKRSYLRACIKEAMR 325
           G DTT++ +S  LY MA+  + Q + REEV               GK +YL  CIKE+ R
Sbjct: 302 GHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFR 361

Query: 326 ILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           + P V    R+ +K    + G  +P    I+     L      +P P  F   R+ T  +
Sbjct: 362 LYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENA 421

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
                   HPFA  PF  G R+CIG++ A  E++   +  +  F+
Sbjct: 422 S-----KRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 461


>AL593856-6|CAI16982.1|  512|Homo sapiens cytochrome P450, family 4,
           subfamily B, polypeptide 1 protein.
          Length = 512

 Score = 64.9 bits (151), Expect = 6e-10
 Identities = 50/165 (30%), Positives = 75/165 (45%), Gaps = 17/165 (10%)

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMS-----------KNGKRSYLRACIKEAMR 325
           G DTT++ +S  LY MA+  + Q + REEV               GK +YL  CIKE+ R
Sbjct: 317 GHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFR 376

Query: 326 ILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           + P V    R+ +K    + G  +P    I+     L      +P P  F   R+ T  +
Sbjct: 377 LYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENA 436

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
                   HPFA  PF  G R+CIG++ A  E++   +  +  F+
Sbjct: 437 S-----KRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 476


>AL593856-5|CAI16981.1|  511|Homo sapiens cytochrome P450, family 4,
           subfamily B, polypeptide 1 protein.
          Length = 511

 Score = 64.9 bits (151), Expect = 6e-10
 Identities = 50/165 (30%), Positives = 75/165 (45%), Gaps = 17/165 (10%)

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMS-----------KNGKRSYLRACIKEAMR 325
           G DTT++ +S  LY MA+  + Q + REEV               GK +YL  CIKE+ R
Sbjct: 316 GHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFR 375

Query: 326 ILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           + P V    R+ +K    + G  +P    I+     L      +P P  F   R+ T  +
Sbjct: 376 LYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENA 435

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
                   HPFA  PF  G R+CIG++ A  E++   +  +  F+
Sbjct: 436 S-----KRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 475


>AL356793-4|CAI22559.1|  511|Homo sapiens cytochrome P450, family 4,
           subfamily B, polypeptide 1 protein.
          Length = 511

 Score = 64.9 bits (151), Expect = 6e-10
 Identities = 50/165 (30%), Positives = 75/165 (45%), Gaps = 17/165 (10%)

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMS-----------KNGKRSYLRACIKEAMR 325
           G DTT++ +S  LY MA+  + Q + REEV               GK +YL  CIKE+ R
Sbjct: 316 GHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFR 375

Query: 326 ILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           + P V    R+ +K    + G  +P    I+     L      +P P  F   R+ T  +
Sbjct: 376 LYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENA 435

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
                   HPFA  PF  G R+CIG++ A  E++   +  +  F+
Sbjct: 436 S-----KRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 475


>AL356793-3|CAI22557.1|  512|Homo sapiens cytochrome P450, family 4,
           subfamily B, polypeptide 1 protein.
          Length = 512

 Score = 64.9 bits (151), Expect = 6e-10
 Identities = 50/165 (30%), Positives = 75/165 (45%), Gaps = 17/165 (10%)

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMS-----------KNGKRSYLRACIKEAMR 325
           G DTT++ +S  LY MA+  + Q + REEV               GK +YL  CIKE+ R
Sbjct: 317 GHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFR 376

Query: 326 ILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           + P V    R+ +K    + G  +P    I+     L      +P P  F   R+ T  +
Sbjct: 377 LYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENA 436

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
                   HPFA  PF  G R+CIG++ A  E++   +  +  F+
Sbjct: 437 S-----KRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 476


>AL356793-2|CAI22558.1|  497|Homo sapiens cytochrome P450, family 4,
           subfamily B, polypeptide 1 protein.
          Length = 497

 Score = 64.9 bits (151), Expect = 6e-10
 Identities = 50/165 (30%), Positives = 75/165 (45%), Gaps = 17/165 (10%)

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMS-----------KNGKRSYLRACIKEAMR 325
           G DTT++ +S  LY MA+  + Q + REEV               GK +YL  CIKE+ R
Sbjct: 302 GHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFR 361

Query: 326 ILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           + P V    R+ +K    + G  +P    I+     L      +P P  F   R+ T  +
Sbjct: 362 LYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENA 421

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
                   HPFA  PF  G R+CIG++ A  E++   +  +  F+
Sbjct: 422 S-----KRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 461


>X02612-1|CAA26458.1|  512|Homo sapiens cytochrome P(1)-450 protein.
          Length = 512

 Score = 64.5 bits (150), Expect = 7e-10
 Identities = 59/216 (27%), Positives = 105/216 (48%), Gaps = 18/216 (8%)

Query: 231 KYFIKKALDDIKMNKSKSDDEKPVLEKL-LDINEEYAYIMASDMLVAGVDTTSNTMSATL 289
           K F K  + DI  +  +   EK + E   + +++E    +  D+  AG DT +  +S +L
Sbjct: 271 KTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSL 330

Query: 290 YLMAINQDKQQKLREEVMSKNGK--------RS---YLRACIKEAMRILPVVSGNM-RRT 337
             + +N   Q+K++EE+ +  G+        RS   Y+ A I E  R   +V   +   T
Sbjct: 331 MYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSLVPFTIPHST 390

Query: 338 TKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFAN 397
           T++ ++ G++IP+   +      ++  +K +  P+EF+PER+LT                
Sbjct: 391 TRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDG---AIDKVLSEKV 447

Query: 398 SPFGFGVRSCIGRRIAELEVETFLSKIVENFQVEWS 433
             FG G R CIG  +A  EV  FL+ +++  +VE+S
Sbjct: 448 IIFGMGKRKCIGETVARWEVFLFLAILLQ--RVEFS 481


>AY064486-1|AAL57721.1|  511|Homo sapiens cytochrome P450 protein.
          Length = 511

 Score = 64.5 bits (150), Expect = 7e-10
 Identities = 50/165 (30%), Positives = 74/165 (44%), Gaps = 17/165 (10%)

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMS-----------KNGKRSYLRACIKEAMR 325
           G DTT+  +S  LY MA+  + Q + REEV               GK +YL  CIKE+ R
Sbjct: 316 GHDTTTGGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFR 375

Query: 326 ILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           + P V    R+ +K    + G  +P    I+     L      +P P  F   R+ T  +
Sbjct: 376 LYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENA 435

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
                   HPFA  PF  G R+CIG++ A  E++   +  +  F+
Sbjct: 436 S-----KRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 475


>X04300-1|CAA27843.1|  512|Homo sapiens P-450 c protein.
          Length = 512

 Score = 64.1 bits (149), Expect = 1e-09
 Identities = 60/216 (27%), Positives = 104/216 (48%), Gaps = 18/216 (8%)

Query: 231 KYFIKKALDDIKMNKSKSDDEKPVLEKL-LDINEEYAYIMASDMLVAGVDTTSNTMSATL 289
           K F K  + DI  +  +   EK + E   + +++E    +  D+  AG DT +  +S +L
Sbjct: 271 KTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSL 330

Query: 290 YLMAINQDKQQKLREEVMSKNGK--------RS---YLRACIKEAMRILPVVSGNM-RRT 337
             + +N   Q+K++EE+ +  G+        RS   Y+ A I E  R    V   +   T
Sbjct: 331 MYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHST 390

Query: 338 TKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFAN 397
           T++ ++ G++IP+   +      ++  +K +  P+EF+PER+LT                
Sbjct: 391 TRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDG---AIDKVLSEKV 447

Query: 398 SPFGFGVRSCIGRRIAELEVETFLSKIVENFQVEWS 433
             FG G R CIG  IA  EV  FL+ +++  +VE+S
Sbjct: 448 IIFGMGKRKCIGETIARWEVFLFLAILLQ--RVEFS 481


>M61854-1|AAB59426.1|  490|Homo sapiens cytochrome protein.
          Length = 490

 Score = 64.1 bits (149), Expect = 1e-09
 Identities = 57/225 (25%), Positives = 100/225 (44%), Gaps = 26/225 (11%)

Query: 221 KMYEEQENLTKYFIKKALDD--IKMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVAGV 278
           K+ E QE++     +  +D   IKM K K + +        +   E   I A+D+L AG 
Sbjct: 247 KVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQS-------EFTIENLVITAADLLGAGT 299

Query: 279 DTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKNGKRSYLRACIKEAMRIL 327
           +TTS T+   L L+  + +   K++EE+           M   G   Y  A + E  R +
Sbjct: 300 ETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYI 359

Query: 328 PVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDP 386
            ++  ++    T +     Y IP+   I  +   +    K +P P  F P  +L    + 
Sbjct: 360 DLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGN- 418

Query: 387 LYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
             +  ++ F   PF  G R C+G  +A +E+  FL+ I++NF ++
Sbjct: 419 --FKKSNYFM--PFSAGKRICVGEGLARMELFLFLTFILQNFNLK 459


>L07093-1|AAA36660.1|  468|Homo sapiens cytochrome P450 protein.
          Length = 468

 Score = 64.1 bits (149), Expect = 1e-09
 Identities = 57/225 (25%), Positives = 100/225 (44%), Gaps = 26/225 (11%)

Query: 221 KMYEEQENLTKYFIKKALDD--IKMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVAGV 278
           K+ E QE++     +  +D   IKM K K + +        +   E   I A+D+L AG 
Sbjct: 225 KVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQS-------EFTIENLVITAADLLGAGT 277

Query: 279 DTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKNGKRSYLRACIKEAMRIL 327
           +TTS T+   L L+  + +   K++EE+           M   G   Y  A + E  R +
Sbjct: 278 ETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYI 337

Query: 328 PVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDP 386
            ++  ++    T +     Y IP+   I  +   +    K +P P  F P  +L    + 
Sbjct: 338 DLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGN- 396

Query: 387 LYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
             +  ++ F   PF  G R C+G  +A +E+  FL+ I++NF ++
Sbjct: 397 --FKKSNYFM--PFSAGKRICVGEGLARMELFLFLTFILQNFNLK 437


>EF094025-1|ABK41999.1|  512|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 1 protein.
          Length = 512

 Score = 64.1 bits (149), Expect = 1e-09
 Identities = 60/216 (27%), Positives = 104/216 (48%), Gaps = 18/216 (8%)

Query: 231 KYFIKKALDDIKMNKSKSDDEKPVLEKL-LDINEEYAYIMASDMLVAGVDTTSNTMSATL 289
           K F K  + DI  +  +   EK + E   + +++E    +  D+  AG DT +  +S +L
Sbjct: 271 KTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSL 330

Query: 290 YLMAINQDKQQKLREEVMSKNGK--------RS---YLRACIKEAMRILPVVSGNM-RRT 337
             + +N   Q+K++EE+ +  G+        RS   Y+ A I E  R    V   +   T
Sbjct: 331 MYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHST 390

Query: 338 TKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFAN 397
           T++ ++ G++IP+   +      ++  +K +  P+EF+PER+LT                
Sbjct: 391 TRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDG---AIDKVLSEKV 447

Query: 398 SPFGFGVRSCIGRRIAELEVETFLSKIVENFQVEWS 433
             FG G R CIG  IA  EV  FL+ +++  +VE+S
Sbjct: 448 IIFGMGKRKCIGETIARWEVFLFLAILLQ--RVEFS 481


>BC023019-1|AAH23019.1|  512|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 1 protein.
          Length = 512

 Score = 64.1 bits (149), Expect = 1e-09
 Identities = 60/216 (27%), Positives = 104/216 (48%), Gaps = 18/216 (8%)

Query: 231 KYFIKKALDDIKMNKSKSDDEKPVLEKL-LDINEEYAYIMASDMLVAGVDTTSNTMSATL 289
           K F K  + DI  +  +   EK + E   + +++E    +  D+  AG DT +  +S +L
Sbjct: 271 KTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSL 330

Query: 290 YLMAINQDKQQKLREEVMSKNGK--------RS---YLRACIKEAMRILPVVSGNM-RRT 337
             + +N   Q+K++EE+ +  G+        RS   Y+ A I E  R    V   +   T
Sbjct: 331 MYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHST 390

Query: 338 TKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFAN 397
           T++ ++ G++IP+   +      ++  +K +  P+EF+PER+LT                
Sbjct: 391 TRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDG---AIDKVLSEKV 447

Query: 398 SPFGFGVRSCIGRRIAELEVETFLSKIVENFQVEWS 433
             FG G R CIG  IA  EV  FL+ +++  +VE+S
Sbjct: 448 IIFGMGKRKCIGETIARWEVFLFLAILLQ--RVEFS 481


>AY796203-1|AAV41877.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 19 protein.
          Length = 490

 Score = 64.1 bits (149), Expect = 1e-09
 Identities = 57/225 (25%), Positives = 100/225 (44%), Gaps = 26/225 (11%)

Query: 221 KMYEEQENLTKYFIKKALDD--IKMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVAGV 278
           K+ E QE++     +  +D   IKM K K + +        +   E   I A+D+L AG 
Sbjct: 247 KVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQS-------EFTIENLVITAADLLGAGT 299

Query: 279 DTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKNGKRSYLRACIKEAMRIL 327
           +TTS T+   L L+  + +   K++EE+           M   G   Y  A + E  R +
Sbjct: 300 ETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYI 359

Query: 328 PVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDP 386
            ++  ++    T +     Y IP+   I  +   +    K +P P  F P  +L    + 
Sbjct: 360 DLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGN- 418

Query: 387 LYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
             +  ++ F   PF  G R C+G  +A +E+  FL+ I++NF ++
Sbjct: 419 --FKKSNYFM--PFSAGKRICVGEGLARMELFLFLTFILQNFNLK 459


>AY310359-1|AAQ76692.1|  484|Homo sapiens cytochrome P450 1A1
           variant protein.
          Length = 484

 Score = 64.1 bits (149), Expect = 1e-09
 Identities = 60/216 (27%), Positives = 104/216 (48%), Gaps = 18/216 (8%)

Query: 231 KYFIKKALDDIKMNKSKSDDEKPVLEKL-LDINEEYAYIMASDMLVAGVDTTSNTMSATL 289
           K F K  + DI  +  +   EK + E   + +++E    +  D+  AG DT +  +S +L
Sbjct: 243 KTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSL 302

Query: 290 YLMAINQDKQQKLREEVMSKNGK--------RS---YLRACIKEAMRILPVVSGNM-RRT 337
             + +N   Q+K++EE+ +  G+        RS   Y+ A I E  R    V   +   T
Sbjct: 303 MYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHST 362

Query: 338 TKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFAN 397
           T++ ++ G++IP+   +      ++  +K +  P+EF+PER+LT                
Sbjct: 363 TRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDG---AIDKVLSEKV 419

Query: 398 SPFGFGVRSCIGRRIAELEVETFLSKIVENFQVEWS 433
             FG G R CIG  IA  EV  FL+ +++  +VE+S
Sbjct: 420 IIFGMGKRKCIGETIARWEVFLFLAILLQ--RVEFS 453


>AM236047-1|CAJ84704.1|  251|Homo sapiens cytochrome P450 1A1
           protein.
          Length = 251

 Score = 64.1 bits (149), Expect = 1e-09
 Identities = 60/216 (27%), Positives = 104/216 (48%), Gaps = 18/216 (8%)

Query: 231 KYFIKKALDDIKMNKSKSDDEKPVLEKL-LDINEEYAYIMASDMLVAGVDTTSNTMSATL 289
           K F K  + DI  +  +   EK + E   + +++E    +  D+  AG DT +  +S +L
Sbjct: 10  KTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSL 69

Query: 290 YLMAINQDKQQKLREEVMSKNGK--------RS---YLRACIKEAMRILPVVSGNM-RRT 337
             + +N   Q+K++EE+ +  G+        RS   Y+ A I E  R    V   +   T
Sbjct: 70  MYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHST 129

Query: 338 TKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFAN 397
           T++ ++ G++IP+   +      ++  +K +  P+EF+PER+LT                
Sbjct: 130 TRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDG---AIDKVLSEKV 186

Query: 398 SPFGFGVRSCIGRRIAELEVETFLSKIVENFQVEWS 433
             FG G R CIG  IA  EV  FL+ +++  +VE+S
Sbjct: 187 IIFGMGKRKCIGETIARWEVFLFLAILLQ--RVEFS 220


>AL583836-2|CAH74068.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 19 protein.
          Length = 490

 Score = 64.1 bits (149), Expect = 1e-09
 Identities = 57/225 (25%), Positives = 100/225 (44%), Gaps = 26/225 (11%)

Query: 221 KMYEEQENLTKYFIKKALDD--IKMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVAGV 278
           K+ E QE++     +  +D   IKM K K + +        +   E   I A+D+L AG 
Sbjct: 247 KVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQS-------EFTIENLVITAADLLGAGT 299

Query: 279 DTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKNGKRSYLRACIKEAMRIL 327
           +TTS T+   L L+  + +   K++EE+           M   G   Y  A + E  R +
Sbjct: 300 ETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYI 359

Query: 328 PVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDP 386
            ++  ++    T +     Y IP+   I  +   +    K +P P  F P  +L    + 
Sbjct: 360 DLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGN- 418

Query: 387 LYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
             +  ++ F   PF  G R C+G  +A +E+  FL+ I++NF ++
Sbjct: 419 --FKKSNYFM--PFSAGKRICVGEGLARMELFLFLTFILQNFNLK 459


>AL358613-3|CAH72804.1|  428|Homo sapiens cytochrome P450, family
           26, subfamily A, polypeptide 1 protein.
          Length = 428

 Score = 64.1 bits (149), Expect = 1e-09
 Identities = 43/193 (22%), Positives = 91/193 (47%), Gaps = 21/193 (10%)

Query: 270 ASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKN----------------GKR 313
           ++++L  G +TT++  ++ +  + +     QK+REE+ SK                  + 
Sbjct: 225 STELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQL 284

Query: 314 SYLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTE 373
            Y+   IKE +R+ P V G  R   K + + GY IP+  ++ ++      + + +    E
Sbjct: 285 KYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEE 344

Query: 374 FIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVEWS 433
           F P+R++    +     +A  F+  PFG G+RSC+G+  A++ ++ F  ++  +   +  
Sbjct: 345 FNPDRFMLPHPE-----DASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLL 399

Query: 434 GSSPRVEQTSINY 446
              P ++ +   Y
Sbjct: 400 NGPPTMKTSPTVY 412


>AL358613-2|CAH72803.1|  497|Homo sapiens cytochrome P450, family
           26, subfamily A, polypeptide 1 protein.
          Length = 497

 Score = 64.1 bits (149), Expect = 1e-09
 Identities = 43/193 (22%), Positives = 91/193 (47%), Gaps = 21/193 (10%)

Query: 270 ASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKN----------------GKR 313
           ++++L  G +TT++  ++ +  + +     QK+REE+ SK                  + 
Sbjct: 294 STELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQL 353

Query: 314 SYLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTE 373
            Y+   IKE +R+ P V G  R   K + + GY IP+  ++ ++      + + +    E
Sbjct: 354 KYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEE 413

Query: 374 FIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVEWS 433
           F P+R++    +     +A  F+  PFG G+RSC+G+  A++ ++ F  ++  +   +  
Sbjct: 414 FNPDRFMLPHPE-----DASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLL 468

Query: 434 GSSPRVEQTSINY 446
              P ++ +   Y
Sbjct: 469 NGPPTMKTSPTVY 481


>AL133513-2|CAH73444.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 19 protein.
          Length = 490

 Score = 64.1 bits (149), Expect = 1e-09
 Identities = 57/225 (25%), Positives = 100/225 (44%), Gaps = 26/225 (11%)

Query: 221 KMYEEQENLTKYFIKKALDD--IKMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVAGV 278
           K+ E QE++     +  +D   IKM K K + +        +   E   I A+D+L AG 
Sbjct: 247 KVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQS-------EFTIENLVITAADLLGAGT 299

Query: 279 DTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKNGKRSYLRACIKEAMRIL 327
           +TTS T+   L L+  + +   K++EE+           M   G   Y  A + E  R +
Sbjct: 300 ETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYI 359

Query: 328 PVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDP 386
            ++  ++    T +     Y IP+   I  +   +    K +P P  F P  +L    + 
Sbjct: 360 DLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGN- 418

Query: 387 LYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
             +  ++ F   PF  G R C+G  +A +E+  FL+ I++NF ++
Sbjct: 419 --FKKSNYFM--PFSAGKRICVGEGLARMELFLFLTFILQNFNLK 459


>AK223113-1|BAD96833.1|  512|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 1 variant protein.
          Length = 512

 Score = 64.1 bits (149), Expect = 1e-09
 Identities = 60/216 (27%), Positives = 104/216 (48%), Gaps = 18/216 (8%)

Query: 231 KYFIKKALDDIKMNKSKSDDEKPVLEKL-LDINEEYAYIMASDMLVAGVDTTSNTMSATL 289
           K F K  + DI  +  +   EK + E   + +++E    +  D+  AG DT +  +S +L
Sbjct: 271 KTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSL 330

Query: 290 YLMAINQDKQQKLREEVMSKNGK--------RS---YLRACIKEAMRILPVVSGNM-RRT 337
             + +N   Q+K++EE+ +  G+        RS   Y+ A I E  R    V   +   T
Sbjct: 331 MYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHST 390

Query: 338 TKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFAN 397
           T++ ++ G++IP+   +      ++  +K +  P+EF+PER+LT                
Sbjct: 391 TRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDG---AIDKVLSEKV 447

Query: 398 SPFGFGVRSCIGRRIAELEVETFLSKIVENFQVEWS 433
             FG G R CIG  IA  EV  FL+ +++  +VE+S
Sbjct: 448 IIFGMGKRKCIGETIARWEVFLFLAILLQ--RVEFS 481


>AJ563378-3|CAD91347.1|  173|Homo sapiens hypothetical protein
           protein.
          Length = 173

 Score = 64.1 bits (149), Expect = 1e-09
 Identities = 37/114 (32%), Positives = 57/114 (50%), Gaps = 6/114 (5%)

Query: 315 YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEF 374
           YL   + E +R+ PV     R   K+  I G  IP+   +      L    KY+  P EF
Sbjct: 26  YLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEF 85

Query: 375 IPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
            PER+ + K D +      P+  +PFG G R+CIG R A + ++  L ++++NF
Sbjct: 86  RPERF-SKKKDSI-----DPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 133


>AJ563378-2|CAD91647.1|  160|Homo sapiens cytochrome P450 protein.
          Length = 160

 Score = 64.1 bits (149), Expect = 1e-09
 Identities = 37/114 (32%), Positives = 57/114 (50%), Gaps = 6/114 (5%)

Query: 315 YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEF 374
           YL   + E +R+ PV     R   K+  I G  IP+   +      L    KY+  P EF
Sbjct: 13  YLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEF 72

Query: 375 IPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
            PER+ + K D +      P+  +PFG G R+CIG R A + ++  L ++++NF
Sbjct: 73  RPERF-SKKKDSI-----DPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 120


>AF253322-1|AAK25727.1|  512|Homo sapiens cytochrome P450 protein.
          Length = 512

 Score = 64.1 bits (149), Expect = 1e-09
 Identities = 60/216 (27%), Positives = 104/216 (48%), Gaps = 18/216 (8%)

Query: 231 KYFIKKALDDIKMNKSKSDDEKPVLEKL-LDINEEYAYIMASDMLVAGVDTTSNTMSATL 289
           K F K  + DI  +  +   EK + E   + +++E    +  D+  AG DT +  +S +L
Sbjct: 271 KTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSL 330

Query: 290 YLMAINQDKQQKLREEVMSKNGK--------RS---YLRACIKEAMRILPVVSGNM-RRT 337
             + +N   Q+K++EE+ +  G+        RS   Y+ A I E  R    V   +   T
Sbjct: 331 MYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHST 390

Query: 338 TKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFAN 397
           T++ ++ G++IP+   +      ++  +K +  P+EF+PER+LT                
Sbjct: 391 TRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDG---AIDKVLSEKV 447

Query: 398 SPFGFGVRSCIGRRIAELEVETFLSKIVENFQVEWS 433
             FG G R CIG  IA  EV  FL+ +++  +VE+S
Sbjct: 448 IIFGMGKRKCIGETIARWEVFLFLAILLQ--RVEFS 481


>AF005418-1|AAB88881.1|  497|Homo sapiens retinoic acid hydroxylase
           protein.
          Length = 497

 Score = 64.1 bits (149), Expect = 1e-09
 Identities = 43/193 (22%), Positives = 91/193 (47%), Gaps = 21/193 (10%)

Query: 270 ASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKN----------------GKR 313
           ++++L  G +TT++  ++ +  + +     QK+REE+ SK                  + 
Sbjct: 294 STELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQL 353

Query: 314 SYLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTE 373
            Y+   IKE +R+ P V G  R   K + + GY IP+  ++ ++      + + +    E
Sbjct: 354 KYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEE 413

Query: 374 FIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVEWS 433
           F P+R++    +     +A  F+  PFG G+RSC+G+  A++ ++ F  ++  +   +  
Sbjct: 414 FNPDRFMLPHPE-----DASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLL 468

Query: 434 GSSPRVEQTSINY 446
              P ++ +   Y
Sbjct: 469 NGPPTMKTSPTVY 481


>K03191-1|AAA52139.1|  512|Homo sapiens CYP1A1 protein.
          Length = 512

 Score = 63.7 bits (148), Expect = 1e-09
 Identities = 59/216 (27%), Positives = 104/216 (48%), Gaps = 18/216 (8%)

Query: 231 KYFIKKALDDIKMNKSKSDDEKPVLEKL-LDINEEYAYIMASDMLVAGVDTTSNTMSATL 289
           K F K  + DI  +  +   EK + E   + +++E    +  D+  AG DT +  +S +L
Sbjct: 271 KTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSL 330

Query: 290 YLMAINQDKQQKLREEVMSKNGK--------RS---YLRACIKEAMRILPVVSGNM-RRT 337
             + +N   Q+K++EE+ +  G+        RS   Y+ A I E  R    V   +   T
Sbjct: 331 MYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHST 390

Query: 338 TKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFAN 397
           T++ ++ G++IP+   +      ++  +K +  P+EF+PER+LT                
Sbjct: 391 TRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDG---AIDKVLSEKV 447

Query: 398 SPFGFGVRSCIGRRIAELEVETFLSKIVENFQVEWS 433
             FG G R CIG  +A  EV  FL+ +++  +VE+S
Sbjct: 448 IIFGMGKRKCIGETVARWEVFLFLAILLQ--RVEFS 481


>AF491285-1|AAM09532.1|  511|Homo sapiens cytochrome P450 protein.
          Length = 511

 Score = 63.3 bits (147), Expect = 2e-09
 Identities = 49/165 (29%), Positives = 75/165 (45%), Gaps = 17/165 (10%)

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMS-----------KNGKRSYLRACIKEAMR 325
           G DTT++ +S  LY +A+  + Q + REEV               GK +YL  CIKE+ R
Sbjct: 316 GHDTTTSGISWFLYCIALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFR 375

Query: 326 ILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           + P V    R+ +K    + G  +P    I+     L      +P P  F   R+ T  +
Sbjct: 376 LYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENA 435

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
                   HPFA  PF  G R+CIG++ A  E++   +  +  F+
Sbjct: 436 S-----KRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 475


>AY356349-1|AAQ55485.1|  522|Homo sapiens cytochrome P450 protein.
          Length = 522

 Score = 62.9 bits (146), Expect = 2e-09
 Identities = 36/128 (28%), Positives = 62/128 (48%), Gaps = 5/128 (3%)

Query: 311 GKRSYLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPR 370
           G+  Y+   +KE +R+LP VSG  R   + + + GY IP+   + ++ +        Y  
Sbjct: 364 GRLRYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSVMYSIRDTHETAAVYRS 423

Query: 371 PTE-FIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
           P E F PER+   + D    G +      PFG G RSC+G+ +A+  ++    ++V    
Sbjct: 424 PPEGFDPERFGAAREDS--RGASSRLHYIPFGGGARSCLGQELAQAVLQLLAVELVRT-- 479

Query: 430 VEWSGSSP 437
             W  ++P
Sbjct: 480 ARWELATP 487


>AK223108-1|BAD96828.1|  512|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 1 variant protein.
          Length = 512

 Score = 62.9 bits (146), Expect = 2e-09
 Identities = 60/216 (27%), Positives = 102/216 (47%), Gaps = 18/216 (8%)

Query: 231 KYFIKKALDDIKMNKSKSDDEKPVLEKL-LDINEEYAYIMASDMLVAGVDTTSNTMSATL 289
           K F K  + DI  +  +   EK + E   + +++E    +  D+  AG DT +   S +L
Sbjct: 271 KTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTATSWSL 330

Query: 290 YLMAINQDKQQKLREEVMSKNGK--------RS---YLRACIKEAMRILPVVSGNM-RRT 337
             + +N   Q+K++EE+ +  G+        RS   Y+ A I E  R    V   +   T
Sbjct: 331 MYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHST 390

Query: 338 TKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFAN 397
           T++ ++ G++IP+   +      +   +K +  P+EF+PER+LT                
Sbjct: 391 TRDTSLKGFYIPKGRCVFVNQWQIDHDQKLWVNPSEFLPERFLTPDG---AIDKVLSEKV 447

Query: 398 SPFGFGVRSCIGRRIAELEVETFLSKIVENFQVEWS 433
             FG G R CIG  IA  EV  FL+ +++  +VE+S
Sbjct: 448 IIFGMGKRKCIGETIARWEVFLFLAILLQ--RVEFS 481


>X65962-1|CAA46778.1|  356|Homo sapiens cytochrome P-450 II C
           protein.
          Length = 356

 Score = 62.5 bits (145), Expect = 3e-09
 Identities = 47/180 (26%), Positives = 82/180 (45%), Gaps = 17/180 (9%)

Query: 264 EYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKNGK 312
           E   I A+D+L AG +TTS T+   L L+  + +   K++EE+           M   G 
Sbjct: 151 ENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGH 210

Query: 313 RSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRP 371
             Y  A + E  R + ++  ++    T +     Y IP+   I  +   +    K +P P
Sbjct: 211 MPYTDAVVHEVQRYIDLIPTSLPHAVTCDIKFRNYLIPKGTTILTSLTSVLHDNKEFPNP 270

Query: 372 TEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
             F P  +L    +   +  ++ F   PF  G R C+G  +A +E+  FL+ I++NF ++
Sbjct: 271 EMFDPRHFLDEGGN---FKKSNYFM--PFSAGKRICVGEGLARMELFLFLTFILQNFNLK 325


>L39102-1|AAL31348.1|  217|Homo sapiens S-mephenytoin 4-hydroxylase
           protein.
          Length = 217

 Score = 62.5 bits (145), Expect = 3e-09
 Identities = 47/180 (26%), Positives = 82/180 (45%), Gaps = 17/180 (9%)

Query: 264 EYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKNGK 312
           E   I A+D+L AG +TTS T+   L L+  + +   K++EE+           M   G 
Sbjct: 12  ENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGH 71

Query: 313 RSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRP 371
             Y  A + E  R + ++  ++    T +     Y IP+   I  +   +    K +P P
Sbjct: 72  MPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNP 131

Query: 372 TEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
             F P  +L    +   +  ++ F   PF  G R C+G  +A +E+  FL+ I++NF ++
Sbjct: 132 EMFDPRHFLDEGGN---FKKSNYFM--PFSAGKRICVGEGLARMELFLFLTFILQNFNLK 186


>BC096286-1|AAH96286.1|  437|Homo sapiens cytochrome P450, family
           11, subfamily B, polypeptide 1 protein.
          Length = 437

 Score = 62.1 bits (144), Expect = 4e-09
 Identities = 81/346 (23%), Positives = 147/346 (42%), Gaps = 29/346 (8%)

Query: 23  HKLYDIYGPIVRIDSMFSKDAIVLLYDAESAGIILRNENNMPIRISFKSLSYYRQKYKKS 82
           H+ +   GPI R D   +    V+L   E    + + ++  P R+S +    YRQ     
Sbjct: 69  HQTFQELGPIFRYDLGGAGMVCVML--PEDVEKLQQVDSLHPHRMSLEPWVAYRQ----- 121

Query: 83  ENDRTDRPTGLVSDHGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDE 142
                    G+   +G  W+  R  +NP +L P  ++ +   ++ VA D  + L+    +
Sbjct: 122 ---HRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQ 178

Query: 143 NNRIRGQFDQEMNL--WSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQMFVLSNE 200
           N R     D + ++  +++E+  +   G RL     +    S     +  +  MF  + +
Sbjct: 179 NARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHS--PSSASLNFLHALEVMFKSTVQ 236

Query: 201 LDLKP-SIWTYVSTPLFRKTMKMYEEQENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLL 259
           L   P S+  + S  ++++  + ++         I+K   ++  ++ +      V E LL
Sbjct: 237 LMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSI-VAELLL 295

Query: 260 DINEEYAYIMASDM-LVAG-VDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKRS--- 314
           +       I A+ M L AG VDTT   +  TL+ +A N + QQ LR+E ++     S   
Sbjct: 296 NAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHP 355

Query: 315 --------YLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENV 352
                    LRA +KE +R+ PV     R  + +  +  YHIP  V
Sbjct: 356 QKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGV 401


>M12079-1|AAA52152.1|  191|Homo sapiens POR protein.
          Length = 191

 Score = 61.3 bits (142), Expect = 7e-09
 Identities = 51/187 (27%), Positives = 92/187 (49%), Gaps = 17/187 (9%)

Query: 259 LDINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGK------ 312
           + +++E    +  D+  AG DT +  +S +L  + +N   Q+K++EE+ +  G+      
Sbjct: 6   VQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRL 65

Query: 313 --RS---YLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEK 366
             RS   Y+ A I E  R    V   +   TT++ ++ G++IP+   +      ++  +K
Sbjct: 66  SDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQK 125

Query: 367 YYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVE 426
            +  P+EF+PER+LT                  FG G R CIG  +A  EV  FL+ +++
Sbjct: 126 LWVNPSEFLPERFLTPDG---AIDKVLSEKVIIFGMGKRKCIGETVARWEVFLFLAILLQ 182

Query: 427 NFQVEWS 433
             +VE+S
Sbjct: 183 --RVEFS 187


>S67581-1|AAB29503.1|  591|Homo sapiens fatty acid omega-hydroxylase
           protein.
          Length = 591

 Score = 60.9 bits (141), Expect = 9e-09
 Identities = 49/160 (30%), Positives = 74/160 (46%), Gaps = 21/160 (13%)

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG-----------KRSYLRACIKEAMR 325
           G DTT++ +S  LY +A +   Q++ REE+ S  G           +  Y   CIKEA+R
Sbjct: 322 GHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALR 381

Query: 326 ILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           + P V G  R  +       G  +P+ + +  +   L    K +P P  F P R+    +
Sbjct: 382 LYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPSRFAPGSA 441

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIA--ELEVETFLS 422
                   H  A  PF  G R+CIG++ A  EL+V T L+
Sbjct: 442 Q-------HSHAFLPFSGGSRNCIGKQFAMNELKVATALT 474


>S67580-1|AAB29502.1|  519|Homo sapiens fatty acid omega-hydroxylase
           protein.
          Length = 519

 Score = 60.9 bits (141), Expect = 9e-09
 Identities = 49/160 (30%), Positives = 74/160 (46%), Gaps = 21/160 (13%)

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG-----------KRSYLRACIKEAMR 325
           G DTT++ +S  LY +A +   Q++ REE+ S  G           +  Y   CIKEA+R
Sbjct: 322 GHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALR 381

Query: 326 ILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           + P V G  R  +       G  +P+ + +  +   L    K +P P  F P R+    +
Sbjct: 382 LYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPSRFAPGSA 441

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIA--ELEVETFLS 422
                   H  A  PF  G R+CIG++ A  EL+V T L+
Sbjct: 442 Q-------HSHAFLPFSGGSRNCIGKQFAMNELKVATALT 474


>BC067429-1|AAH67429.1|  516|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 2 protein.
          Length = 516

 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 87/369 (23%), Positives = 158/369 (42%), Gaps = 43/369 (11%)

Query: 95  SDHGELWKSFR----SAVNPVLLQPKTIRLYSSALEEVATDMVERLRSLRDENNRIRGQF 150
           +D G +W + R    +A+N   +        S  LEE  +   + L S   E     G F
Sbjct: 127 TDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHF 186

Query: 151 DQEMNLWSLESIGVVALGNRLN--CFDSNLQDDSP-VKRLIECVHQMFVLS---NELDLK 204
           D    +       VV++ N +   CF  +  + S  +  L++  H+    +   N LD  
Sbjct: 187 DPYNQV-------VVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFF 239

Query: 205 PSIWTYVSTPLFRKTMKMYEE-----QENLTKY---FIKKALDDIKMNKSKSDDEKPVLE 256
           P I  Y+  P  ++     +      Q+ + ++   F K ++ DI     K   + P   
Sbjct: 240 P-ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRAS 298

Query: 257 KLLDINEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV---------- 306
             L I +E    + +D+  AG DT +  +S +L  +    + Q+K+++E+          
Sbjct: 299 GNL-IPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRP 357

Query: 307 -MSKNGKRSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMM 364
            +S   +  YL A I E  R  P +   +   TT++  + G++IP+   +      ++  
Sbjct: 358 RLSDRPQLPYLEAFILETFRHSPFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHD 417

Query: 365 EKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKI 424
            + +  P+EF PER+LT  +D              FG G R CIG  +A+ E+  FL+ +
Sbjct: 418 PELWEDPSEFRPERFLT--ADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAIL 475

Query: 425 VENFQVEWS 433
           ++  Q+E+S
Sbjct: 476 LQ--QLEFS 482


>BC067433-1|AAH67433.1|  493|Homo sapiens cytochrome P450, family 2,
           subfamily E, polypeptide 1 protein.
          Length = 493

 Score = 60.1 bits (139), Expect = 2e-08
 Identities = 42/176 (23%), Positives = 81/176 (46%), Gaps = 17/176 (9%)

Query: 268 IMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEV-----------MSKNGKRSYL 316
           +  +D+  AG +TTS T+   L ++    + ++KL EE+           +    +  Y+
Sbjct: 291 VTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYM 350

Query: 317 RACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFI 375
            A ++E  R + +V  N+    T++    GY IP+   +      +    + +P P +F 
Sbjct: 351 DAVVREIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFK 410

Query: 376 PERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVE 431
           PE +L N++    Y +       PF  G R C G  +A +E+   L  I+++F ++
Sbjct: 411 PEHFL-NENGKFKYSDYF----KPFSTGKRVCAGEGLARMELFLLLCAILQHFNLK 461


>AF525488-1|AAO16078.1|  519|Homo sapiens cytochrome P450, subfamily
           IVA, polypeptide 11 protein.
          Length = 519

 Score = 60.1 bits (139), Expect = 2e-08
 Identities = 49/160 (30%), Positives = 74/160 (46%), Gaps = 21/160 (13%)

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG-----------KRSYLRACIKEAMR 325
           G DTT++ +S  LY +A +   Q++ REE+ S  G           +  Y   CIKEA+R
Sbjct: 322 GHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALR 381

Query: 326 ILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           + P V G  R  +       G  +P+ + +  +   L    K +P P  F P R+    +
Sbjct: 382 LFPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSA 441

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIA--ELEVETFLS 422
                   H  A  PF  G R+CIG++ A  EL+V T L+
Sbjct: 442 Q-------HSHAFLPFSGGSRNCIGKQFAMNELKVATALT 474


>U37143-1|AAC50370.2|  502|Homo sapiens cytochrome P450
           monooxygenase CYP2J2 protein.
          Length = 502

 Score = 59.7 bits (138), Expect = 2e-08
 Identities = 46/179 (25%), Positives = 78/179 (43%), Gaps = 18/179 (10%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGK--------- 312
           +EE       D+  AG +TTS T+   L  MA+  + Q+K++ E+    G+         
Sbjct: 297 HEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAAR 356

Query: 313 --RSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R+  ++  N+ R  T +  + GYH+P+   I      L      + 
Sbjct: 357 ESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWA 416

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
            P  F P+ +L N      +     F   PF  G R+C+G ++A  E+  F + +++ F
Sbjct: 417 TPDTFNPDHFLENGQ----FKKREAF--MPFSIGKRACLGEQLARTELFIFFTSLMQKF 469


>L04751-1|AAA58436.1|  519|Homo sapiens cytochrome P450 protein.
          Length = 519

 Score = 59.7 bits (138), Expect = 2e-08
 Identities = 49/160 (30%), Positives = 74/160 (46%), Gaps = 21/160 (13%)

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG-----------KRSYLRACIKEAMR 325
           G DTT++ +S  LY +A +   Q++ REE+ S  G           +  Y   CIKEA+R
Sbjct: 322 GHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALR 381

Query: 326 ILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           + P V G  R  +       G  +P+ + +  +   L    K +P P  F P R+    +
Sbjct: 382 LYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSA 441

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIA--ELEVETFLS 422
                   H  A  PF  G R+CIG++ A  EL+V T L+
Sbjct: 442 Q-------HSHAFLPFSGGSRNCIGKQFAMNELKVATALT 474


>D26481-1|BAA05491.1|  519|Homo sapiens fatty acids
           omega-hydroxylase protein.
          Length = 519

 Score = 59.7 bits (138), Expect = 2e-08
 Identities = 49/160 (30%), Positives = 74/160 (46%), Gaps = 21/160 (13%)

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG-----------KRSYLRACIKEAMR 325
           G DTT++ +S  LY +A +   Q++ REE+ S  G           +  Y   CIKEA+R
Sbjct: 322 GHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALR 381

Query: 326 ILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           + P V G  R  +       G  +P+ + +  +   L    K +P P  F P R+    +
Sbjct: 382 LYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSA 441

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIA--ELEVETFLS 422
                   H  A  PF  G R+CIG++ A  EL+V T L+
Sbjct: 442 Q-------HSHAFLPFSGGSRNCIGKQFAMNELKVATALT 474


>BC117165-1|AAI17166.1|  494|Homo sapiens cytochrome P450, family 2,
           subfamily A, polypeptide 7 protein.
          Length = 494

 Score = 59.7 bits (138), Expect = 2e-08
 Identities = 43/179 (24%), Positives = 84/179 (46%), Gaps = 18/179 (10%)

Query: 272 DMLVAGVDTTSNTMSATLYLMAINQDKQQKLREE---VMSKN--------GKRSYLRACI 320
           ++ +AG +T S T+     L+  + + + K+ EE   V+ KN         K  Y+ A I
Sbjct: 297 NLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVI 356

Query: 321 KEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERW 379
            E  R   V+  ++ RR  K+     + +P+  ++      +     ++  P +F P+ +
Sbjct: 357 HEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHF 416

Query: 380 LTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVEWSGSSPR 438
           L +K     +  +  F   PF  G R C G  +A +E+  F + +++NF+++ S  SP+
Sbjct: 417 LDDKGQ---FKKSDAFV--PFSIGKRYCFGEGLARMELFLFFTTVMQNFRLK-SSQSPK 469


>BC032594-1|AAH32594.1|  502|Homo sapiens cytochrome P450, family 2,
           subfamily J, polypeptide 2 protein.
          Length = 502

 Score = 59.7 bits (138), Expect = 2e-08
 Identities = 46/179 (25%), Positives = 78/179 (43%), Gaps = 18/179 (10%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGK--------- 312
           +EE       D+  AG +TTS T+   L  MA+  + Q+K++ E+    G+         
Sbjct: 297 HEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAAR 356

Query: 313 --RSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R+  ++  N+ R  T +  + GYH+P+   I      L      + 
Sbjct: 357 ESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWA 416

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
            P  F P+ +L N      +     F   PF  G R+C+G ++A  E+  F + +++ F
Sbjct: 417 TPDTFNPDHFLENGQ----FKKREAF--MPFSIGKRACLGEQLARTELFIFFTSLMQKF 469


>BC032322-1|AAH32322.1|  509|Homo sapiens cytochrome P450, family
           51, subfamily A, polypeptide 1 protein.
          Length = 509

 Score = 59.7 bits (138), Expect = 2e-08
 Identities = 60/256 (23%), Positives = 114/256 (44%), Gaps = 33/256 (12%)

Query: 210 YVSTPLFRKTMKMYEEQENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLD--------I 261
           ++  P FR+  + + E +++      KA+   + ++ K DD   +L+ LLD        +
Sbjct: 250 WLPLPSFRRRDRAHREIKDI----FYKAIQKRRQSQEKIDD---ILQTLLDATYKDGRPL 302

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKR-------- 313
            ++    M   +L+AG  T+S T +   + +A ++  Q+K   E  +  G+         
Sbjct: 303 TDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQ 362

Query: 314 ----SYLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               + L  CIKE +R+ P V   MR       + GY IP    +  +      ++  + 
Sbjct: 363 LKDLNLLDRCIKETLRLRPPVMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWV 422

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
              +F P+R+L  + +P    +   FA  PFG G   CIG   A ++++T  S ++  ++
Sbjct: 423 ERLDFNPDRYL--QDNP---ASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYE 477

Query: 430 VEW-SGSSPRVEQTSI 444
            +   G  P V  T++
Sbjct: 478 FDLIDGYFPTVNYTTM 493


>AY426985-1|AAQ93356.1|  502|Homo sapiens cytochrome P450, family 2,
           subfamily J, polypeptide 2 protein.
          Length = 502

 Score = 59.7 bits (138), Expect = 2e-08
 Identities = 46/179 (25%), Positives = 78/179 (43%), Gaps = 18/179 (10%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGK--------- 312
           +EE       D+  AG +TTS T+   L  MA+  + Q+K++ E+    G+         
Sbjct: 297 HEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAAR 356

Query: 313 --RSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R+  ++  N+ R  T +  + GYH+P+   I      L      + 
Sbjct: 357 ESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWA 416

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
            P  F P+ +L N      +     F   PF  G R+C+G ++A  E+  F + +++ F
Sbjct: 417 TPDTFNPDHFLENGQ----FKKREAF--MPFSIGKRACLGEQLARTELFIFFTSLMQKF 469


>AY369778-1|AAQ56847.1|  519|Homo sapiens cytochrome P450, family 4,
           subfamily A, polypeptide 11 protein.
          Length = 519

 Score = 59.7 bits (138), Expect = 2e-08
 Identities = 49/160 (30%), Positives = 74/160 (46%), Gaps = 21/160 (13%)

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG-----------KRSYLRACIKEAMR 325
           G DTT++ +S  LY +A +   Q++ REE+ S  G           +  Y   CIKEA+R
Sbjct: 322 GHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALR 381

Query: 326 ILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           + P V G  R  +       G  +P+ + +  +   L    K +P P  F P R+    +
Sbjct: 382 LYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSA 441

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIA--ELEVETFLS 422
                   H  A  PF  G R+CIG++ A  EL+V T L+
Sbjct: 442 Q-------HSHAFLPFSGGSRNCIGKQFAMNELKVATALT 474


>AL731892-3|CAH72778.1|  519|Homo sapiens cytochrome P450, family 4,
           subfamily A, polypeptide 11 protein.
          Length = 519

 Score = 59.7 bits (138), Expect = 2e-08
 Identities = 49/160 (30%), Positives = 74/160 (46%), Gaps = 21/160 (13%)

Query: 277 GVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNG-----------KRSYLRACIKEAMR 325
           G DTT++ +S  LY +A +   Q++ REE+ S  G           +  Y   CIKEA+R
Sbjct: 322 GHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALR 381

Query: 326 ILPVVSGNMRRTTKEYNIL-GYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKS 384
           + P V G  R  +       G  +P+ + +  +   L    K +P P  F P R+    +
Sbjct: 382 LYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSA 441

Query: 385 DPLYYGNAHPFANSPFGFGVRSCIGRRIA--ELEVETFLS 422
                   H  A  PF  G R+CIG++ A  EL+V T L+
Sbjct: 442 Q-------HSHAFLPFSGGSRNCIGKQFAMNELKVATALT 474


>AF272142-1|AAM44456.1|  502|Homo sapiens cytochrome P450 protein.
          Length = 502

 Score = 59.7 bits (138), Expect = 2e-08
 Identities = 46/179 (25%), Positives = 78/179 (43%), Gaps = 18/179 (10%)

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGK--------- 312
           +EE       D+  AG +TTS T+   L  MA+  + Q+K++ E+    G+         
Sbjct: 297 HEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAAR 356

Query: 313 --RSYLRACIKEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               Y  A I E  R+  ++  N+ R  T +  + GYH+P+   I      L      + 
Sbjct: 357 ESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWA 416

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENF 428
            P  F P+ +L N      +     F   PF  G R+C+G ++A  E+  F + +++ F
Sbjct: 417 TPDTFNPDHFLENGQ----FKKREAF--MPFSIGKRACLGEQLARTELFIFFTSLMQKF 469


>X13930-1|CAA32118.1|  494|Homo sapiens protein ( Human CYP2A4 mRNA
           for P-450 IIA4 protein. ).
          Length = 494

 Score = 59.3 bits (137), Expect = 3e-08
 Identities = 42/179 (23%), Positives = 83/179 (46%), Gaps = 18/179 (10%)

Query: 272 DMLVAGVDTTSNTMSATLYLMAINQDKQQKLREE---VMSKN--------GKRSYLRACI 320
           ++ + G +T S T+     L+  + + + K+ EE   V+ KN         K  Y+ A I
Sbjct: 297 NLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVI 356

Query: 321 KEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERW 379
            E  R   V+  ++ RR  K+     + +P+  ++      +     ++  P +F P+ +
Sbjct: 357 HEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHF 416

Query: 380 LTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVEWSGSSPR 438
           L  K     +  +  F   PF  G R+C G  +A +E+  F + +++NF+++ S  SP+
Sbjct: 417 LNEKGQ---FKKSDAFV--PFSIGKRNCFGEGLARMELFLFFTTVMQNFRLK-SSQSPK 469


>X13929-1|CAA32117.1|  448|Homo sapiens P-450 IIA3 protein (1 is 3rd
           base in codon) protein.
          Length = 448

 Score = 59.3 bits (137), Expect = 3e-08
 Identities = 42/179 (23%), Positives = 83/179 (46%), Gaps = 18/179 (10%)

Query: 272 DMLVAGVDTTSNTMSATLYLMAINQDKQQKLREE---VMSKN--------GKRSYLRACI 320
           ++ + G +T S T+     L+  + + + K+ EE   V+ KN         K  Y+ A I
Sbjct: 251 NLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVI 310

Query: 321 KEAMRILPVVSGNM-RRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYPRPTEFIPERW 379
            E  R   V+  ++ RR  K+     + +P+  ++      +     ++  P +F P+ +
Sbjct: 311 HEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHF 370

Query: 380 LTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQVEWSGSSPR 438
           L  K     +  +  F   PF  G R+C G  +A +E+  F + +++NF+++ S  SP+
Sbjct: 371 LNEKGQ---FKKSDAFV--PFSIGKRNCFGEGLARMELFLFFTTVMQNFRLK-SSQSPK 423


>U23942-1|AAB39951.1|  509|Homo sapiens lanosterol 14-demethylase
           cytochrome P450 protein.
          Length = 509

 Score = 59.3 bits (137), Expect = 3e-08
 Identities = 59/256 (23%), Positives = 114/256 (44%), Gaps = 33/256 (12%)

Query: 210 YVSTPLFRKTMKMYEEQENLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLD--------I 261
           ++  P FR+  + + E +++      KA+   + ++ K DD   +L+ LLD        +
Sbjct: 250 WLPLPSFRRRDRAHREIKDI----FYKAIQKRRQSQEKIDD---ILQTLLDATYKDGRPL 302

Query: 262 NEEYAYIMASDMLVAGVDTTSNTMSATLYLMAINQDKQQKLREEVMSKNGKR-------- 313
            ++    M   +L+AG  T+S T +   + +A ++  Q+K   E  +  G+         
Sbjct: 303 TDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQ 362

Query: 314 ----SYLRACIKEAMRILPVVSGNMRRTTKEYNILGYHIPENVDIAFAHQHLSMMEKYYP 369
               + L  CIKE +R+ P +   MR       + GY IP    +  +      ++  + 
Sbjct: 363 LKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWV 422

Query: 370 RPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCIGRRIAELEVETFLSKIVENFQ 429
              +F P+R+L  + +P    +   FA  PFG G   CIG   A ++++T  S ++  ++
Sbjct: 423 ERLDFNPDRYL--QDNP---ASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYE 477

Query: 430 VEW-SGSSPRVEQTSI 444
            +   G  P V  T++
Sbjct: 478 FDLIDGYFPTVNYTTM 493


  Database: human
    Posted date:  Oct 5, 2007 11:13 AM
  Number of letters in database: 73,234,838
  Number of sequences in database:  224,733
  
Lambda     K      H
   0.319    0.135    0.393 

Gapped
Lambda     K      H
   0.279   0.0580    0.190 


Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 66,738,646
Number of Sequences: 224733
Number of extensions: 2770942
Number of successful extensions: 7442
Number of sequences better than 10.0: 452
Number of HSP's better than 10.0 without gapping: 356
Number of HSP's successfully gapped in prelim test: 96
Number of HSP's that attempted gapping in prelim test: 6312
Number of HSP's gapped (non-prelim): 559
length of query: 458
length of database: 73,234,838
effective HSP length: 92
effective length of query: 366
effective length of database: 52,559,402
effective search space: 19236741132
effective search space used: 19236741132
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.8 bits)
S2: 67 (31.1 bits)