Silkworm BLAST Result against human

BLASTP 2.2.12 [Aug-07-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= BGIBMGA001268-TA|BGIBMGA001268-PA|IPR011009|Protein
kinase-like, IPR008973|C2 calcium/lipid-binding region, CaLB,
IPR000403|Phosphatidylinositol 3- and 4-kinase, catalytic,
IPR000341|Phosphoinositide 3-kinase, ras-binding,
IPR002420|Phosphoinositide 3-kinase, C2, IPR001263|Phosphoinositide
3-kinase accessory region PIK, IPR001683|Phox-like
         (1505 letters)

Database: human 
           224,733 sequences; 73,234,838 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

BC113658-1|AAI13659.1| 1686|Homo sapiens phosphoinositide-3-kina...   542   e-153
Y13367-1|CAA73797.1| 1686|Homo sapiens phosphoinositide 3-kinase...   535   e-151
BC132876-1|AAI32877.1| 1634|Homo sapiens phosphoinositide-3-kina...   475   e-133
AL606489-4|CAI16572.1| 1634|Homo sapiens phosphoinositide-3-kina...   475   e-133
AB210006-1|BAE06088.1| 1645|Homo sapiens PIK3C2B variant protein...   475   e-133
Y11312-1|CAA72168.1| 1634|Homo sapiens phosphoinositide 3-kinase...   474   e-132
Y13892-1|CAA74194.1| 1609|Homo sapiens PI-3 kinase protein.           471   e-132
BC130277-1|AAI30278.1| 1444|Homo sapiens phosphoinositide-3-kina...   311   1e-83
AJ000008-1|CAA03853.1| 1448|Homo sapiens PI3-kinase protein.          308   1e-82
S67334-1|AAB29081.1| 1070|Homo sapiens phosphatidylinositol 3-ki...   234   2e-60
BC114432-1|AAI14433.1| 1070|Homo sapiens phosphoinositide-3-kina...   234   2e-60
AJ297549-1|CAC21449.1| 1070|Homo sapiens phosphatidylinositol 3-...   234   2e-60
BC035683-1|AAH35683.1| 1102|Homo sapiens PIK3CG protein protein.      215   1e-54
AC005018-1|AAQ96873.1| 1102|Homo sapiens unknown protein.             215   1e-54
X83368-1|CAA58284.1| 1101|Homo sapiens idem protein.                  214   2e-54
AF327656-1|AAG61115.1| 1102|Homo sapiens phosphoinositide-3-kina...   214   2e-54
U57843-1|AAB53966.1| 1068|Homo sapiens phosphatidylinositol 3-ki...   196   4e-49
Y10055-1|CAA71149.2| 1044|Homo sapiens phosphoinositide 3-kinase...   195   1e-48
U86453-1|AAC25677.1| 1044|Homo sapiens phosphatidylinositol 3-ki...   195   1e-48
DQ263596-1|ABB83816.1| 1044|Homo sapiens phosphoinositide-3-kina...   195   1e-48
DQ263595-1|ABB83815.1| 1044|Homo sapiens phosphoinositide-3-kina...   195   1e-48
DQ263594-1|ABB83814.1| 1044|Homo sapiens phosphoinositide-3-kina...   195   1e-48
BC132921-1|AAI32922.1| 1044|Homo sapiens phosphoinositide-3-kina...   195   1e-48
BC132919-1|AAI32920.1| 1044|Homo sapiens phosphoinositide-3-kina...   195   1e-48
AL691449-6|CAI15703.1| 1044|Homo sapiens phosphoinositide-3-kina...   195   1e-48
AL691449-5|CAI15702.1| 1068|Homo sapiens phosphoinositide-3-kina...   195   1e-48
AB208835-1|BAD92072.1|  845|Homo sapiens phosphoinositide-3-kina...   195   1e-48
Z29090-1|CAA82333.1| 1068|Homo sapiens phosphatidylinositol 3-ki...   185   1e-45
U79143-1|AAB39753.1| 1068|Homo sapiens phosphoinositide 3'-hydro...   183   4e-45
BC113603-1|AAI13604.1| 1068|Homo sapiens phosphoinositide-3-kina...   183   4e-45
BC113601-1|AAI13602.1| 1068|Homo sapiens phosphoinositide-3-kina...   183   4e-45
AB210020-1|BAE06102.1| 1069|Homo sapiens PIK3CA variant protein ...   183   4e-45
BC003393-1|AAH03393.1|  286|Homo sapiens Unknown (protein for IM...   181   2e-44
BC053651-1|AAH53651.1|  887|Homo sapiens phosphoinositide-3-kina...   138   1e-31
BC033004-1|AAH33004.1|  887|Homo sapiens phosphoinositide-3-kina...   138   1e-31
Z46973-1|CAA87094.1|  887|Homo sapiens phosphatidylinositol 3-ki...   138   2e-31
L36151-1|AAA56839.1|  854|Homo sapiens phosphatidylinositol 4-ki...   116   9e-25
BC018120-1|AAH18120.2|  903|Homo sapiens PIK4CA protein protein.      116   9e-25
AF012872-1|AAD13352.1| 2044|Homo sapiens phosphatidylinositol 4-...   116   9e-25
AB210002-1|BAE06084.1| 2121|Homo sapiens PIK4CA variant protein ...   116   9e-25
BC053654-1|AAH53654.1|  895|Homo sapiens PIK4CA protein protein.      113   5e-24
BC020225-1|AAH20225.2|  539|Homo sapiens LOC220686 protein protein.   109   1e-22
U81802-1|AAC51156.1|  801|Homo sapiens PtdIns 4-kinase protein.        98   2e-19
BC040300-1|AAH40300.1|  801|Homo sapiens PIK4CB protein protein.       98   2e-19
BC000029-1|AAH00029.1|  801|Homo sapiens PIK4CB protein protein.       98   2e-19
AL391069-7|CAH70326.1|  828|Homo sapiens phosphatidylinositol 4-...    98   2e-19
AL391069-6|CAH70324.1|  816|Homo sapiens phosphatidylinositol 4-...    98   2e-19
AL391069-5|CAH70325.1|  801|Homo sapiens phosphatidylinositol 4-...    98   2e-19
AJ011123-1|CAA09496.1|  816|Homo sapiens NPIK-C protein protein.       98   2e-19
AJ011121-1|CAA09495.1|  816|Homo sapiens NPIK-A protein protein.       98   2e-19
AB005910-1|BAA21661.1|  828|Homo sapiens phosphatidylinositol 4-...    98   2e-19
CR456378-1|CAG30264.1|  592|Homo sapiens Em:AP000557.3 protein.        89   1e-16
BC139841-1|AAI39842.2|  597|Homo sapiens LOC375133 protein protein.    89   1e-16
AY496423-1|AAS75801.1|  104|Homo sapiens phosphoinositide-3-kina...    60   4e-08
BC022049-1|AAH22049.1|  139|Homo sapiens PIK3CB protein protein.       58   2e-07
U88966-1|AAC39933.1| 2548|Homo sapiens rapamycin associated prot...    52   2e-05
L34075-1|AAA58486.1| 2549|Homo sapiens FKBP-rapamycin associated...    52   2e-05
BC117166-1|AAI17167.1| 2549|Homo sapiens FK506 binding protein 1...    52   2e-05
AL391561-2|CAI17228.1| 2549|Homo sapiens FK506 binding protein 1...    52   2e-05
AL391561-1|CAI17227.1|  754|Homo sapiens FK506 binding protein 1...    52   2e-05
AL109811-7|CAI22105.1| 2549|Homo sapiens FK506 binding protein 1...    52   2e-05
AL109811-3|CAI22101.1|  754|Homo sapiens FK506 binding protein 1...    52   2e-05
AL049653-2|CAI22145.1| 2549|Homo sapiens FK506 binding protein 1...    52   2e-05
AJ300188-3|CAC15570.1| 1188|Homo sapiens rapamycin associated pr...    52   2e-05
AB209995-1|BAE06077.1| 2583|Homo sapiens FRAP1 variant protein p...    52   2e-05
AK126860-1|BAC86726.1|  439|Homo sapiens protein ( Homo sapiens ...    50   6e-05
Y09077-1|CAA70298.1| 2644|Homo sapiens atr protein.                    48   2e-04
U76308-1|AAC50929.1| 2644|Homo sapiens protein kinase ATR protein.     48   2e-04
U49844-1|AAC50405.1| 2644|Homo sapiens FRAP-related protein prot...    48   2e-04
AB208847-1|BAD92084.1|  456|Homo sapiens ataxia telangiectasia a...    48   2e-04
DQ109556-1|AAZ99795.1|  911|Homo sapiens adaptor protein HOFI pr...    42   0.022
U35835-1|AAA79184.1|  930|Homo sapiens DNA-PK protein.                 41   0.039
AY014957-1|AAK00511.1| 3031|Homo sapiens PI-3-kinase-related kin...    41   0.039
AF395444-1|AAM73708.1| 3521|Homo sapiens PI-3-kinase ATX protein.      41   0.039
AF186377-1|AAK58892.1| 2392|Homo sapiens LIP isoform of BLIP pro...    41   0.039
AB061371-1|BAB70696.1| 3657|Homo sapiens phosphatidylinositol 3-...    41   0.039
AB007881-1|BAA24851.2| 1988|Homo sapiens KIAA0421 protein.             41   0.039
U82828-2|AAB65827.1| 3056|Homo sapiens ATM protein.                    40   0.051
U55757-2|AAB38310.1| 1708|Homo sapiens ataxia-telangiectasia mut...    40   0.051
U55757-1|AAB38309.1| 3056|Homo sapiens ataxia-telangiectasia pro...    40   0.051
U47077-1|AAB39925.5| 4128|Homo sapiens DNA-dependent protein kin...    40   0.051
U33841-1|AAC50289.1| 3056|Homo sapiens ATM protein.                    40   0.051
U26455-1|AAA86520.1| 1708|Homo sapiens phosphatidylinositol 3-ki...    40   0.051
AY316117-1|AAP69525.1| 4128|Homo sapiens protein kinase, DNA-act...    40   0.051
AY030284-1|AAK40350.1|  879|Homo sapiens DNA-dependent protein k...    40   0.051
AL359082-1|CAC42395.1|  895|Homo sapiens dJ576K7.1 (FK506 bindin...    40   0.051
AL133355-2|CAI15352.1| 1133|Homo sapiens SH3 and PX domains 2A p...    39   0.12 
AL121929-5|CAI13962.1| 1133|Homo sapiens SH3 and PX domains 2A p...    39   0.12 
U34994-1|AAC50210.3| 4097|Homo sapiens DNA dependent protein kin...    38   0.36 
AB208860-1|BAD92097.1|  726|Homo sapiens protein kinase, DNA-act...    38   0.36 
U57835-1|AAB95193.1|  390|Homo sapiens p47-phox protein.               37   0.63 
M55067-1|AAA59901.1|  390|Homo sapiens autosomal chronic granulo...    37   0.63 
M25665-1|AAA57209.1|  390|Homo sapiens neutrophil cytosol factor...    37   0.63 
BC065731-1|AAH65731.1|  390|Homo sapiens neutrophil cytosolic fa...    37   0.63 
BC002816-1|AAH02816.1|  390|Homo sapiens neutrophil cytosolic fa...    37   0.63 
AK223217-1|BAD96937.1|  390|Homo sapiens neutrophil cytosolic fa...    37   0.63 
AF330627-1|AAK19518.1|  390|Homo sapiens adaptor protein p47phox...    37   0.63 
AF184614-1|AAF34737.1|  390|Homo sapiens p47-phox protein.             37   0.63 
AC083884-6|AAS07465.1|  390|Homo sapiens unknown protein.              37   0.63 
AY220758-1|AAO26044.1| 2756|Homo sapiens ataxia telangiectasia m...    33   5.9  

>BC113658-1|AAI13659.1| 1686|Homo sapiens phosphoinositide-3-kinase,
            class 2, alpha polypeptide protein.
          Length = 1686

 Score =  542 bits (1337), Expect = e-153
 Identities = 382/1168 (32%), Positives = 575/1168 (49%), Gaps = 92/1168 (7%)

Query: 365  DSEHKAFLKMALDVRKKFVYTDERTNPGHVIAARSGGKY--PPNTSIKILVHHAHSDEPI 422
            + E  AF +    ++ KF YT+ RTNPG++++  +  +     N S+K+ +       P+
Sbjct: 378  NEEMAAFCRSITKLKTKFPYTNHRTNPGYLLSPVTAQRNICGENASVKVSIDIEGFQLPV 437

Query: 423  TFTSDVESKVEHVILTVVCSLDEDIRE-DMSGYMLRVRGAKEYLTPGSSLSEYDYIRECV 481
            TFT DV S VE +I+  +C + +D+ + D+  Y+L+V G +E L     L  +++I+ C 
Sbjct: 438  TFTCDVSSTVEIIIMQALCWVHDDLNQVDVGSYVLKVCGQEEVLQNNHCLGSHEHIQNCR 497

Query: 482  RLEKDVTLCL--HEGRDSTLARTERDDAKDSHLTLDDLFPAQGATPMLSFDNLSILLETL 539
            + + ++ L L         LART  DD     L        +     ++   +  LL++ 
Sbjct: 498  KWDTEIRLQLLTFSAMCQNLARTAEDDETPVDLNKHLYQIEKPCKEAMTRHPVEELLDSY 557

Query: 540  EGELSRAIGVTSAEGSCSPKAVFQAVKAICALAGGVETLHVTHTLNAFAQACTAQGANNV 599
              ++  A+ + +   +     V +AV+ IC+   GVETL +T ++    +A       N+
Sbjct: 558  HNQVELALQIENQHRAVDQ--VIKAVRKICSALDGVETLAITESVKKLKRAV------NL 609

Query: 600  VRPEIEREQGAYCSVSLAAGSRRDCVSLQGGRVRDAVXXXXXXXXXXXXXDFRLADAHYQ 659
             R +       +     +  S R  ++ +   V+ ++                   +   
Sbjct: 610  PRSKTADVTSLFGGEDTSRSSTRGSLNPENP-VQVSINQLTAAIYDLLRLHANSGRSPTD 668

Query: 660  APANPAKAVPAHTISETTLFCIEAVHCLPLCW--SHDEYMFHAQIYHGTRPLKTLRFTQA 717
               +      A T +E   F I A H +   W  ++++Y     + H  + L   +  Q+
Sbjct: 669  CAQSSKSVKEAWTTTEQLQFTIFAAHGISSNWVSNYEKYYLICSLSHNGKDL--FKPIQS 726

Query: 718  SKIEC-GGFYPRIIFDTWLNLEDLPVNTLPRESRLVLTLHGRTQRTIDSQHPNENSPPSS 776
             K+     F+  I +D  L +  + ++ LP ES L LTL G   ++  S  P+ N     
Sbjct: 727  KKVGTYKNFFYLIKWDE-LIIFPIQISQLPLESVLHLTLFGILNQSSGSS-PDSNKQRKG 784

Query: 777  QEAEDSGDVLYEQVELGWAALQLFDFDGMLSSGNYVLPLWPTSCDRRXXXXXXXXXXXXX 836
             EA            LG  +L LFDF   L+ G  +L LW TS                 
Sbjct: 785  PEA------------LGKVSLPLFDFKRFLTCGTKLLYLW-TSSHTNSVPGTVTKKGYVM 831

Query: 837  XXXVVNIEIPLYAHTGVKWTSGEEDKQKNISLKDLPSFDSLDGHTQSQLLHLIEQGAYQR 896
               V+ ++ P  A   + +T+ + D+    S+    + ++L+   + +LL ++ + +   
Sbjct: 832  ERIVLQVDFPSPAFD-IIYTTPQVDR----SIIQQHNLETLENDIKGKLLDILHKDSSLG 886

Query: 897  MPTECREVMWEKRQYLVQIPGALPLVLLAATNWYGDHREQLIGLLRLWEKPSPLNAMHLL 956
            +  E +  +WEKR Y  + P  LP +L +A NW   +  +   LL  W    PL A+ LL
Sbjct: 887  LSKEDKAFLWEKRYYCFKHPNCLPKILASAPNWKWVNLAKTYSLLHQWPALYPLIALELL 946

Query: 957  LPCFPDVAVRETAAKLLNEMSDDDLCRVLPQLTQALRHETYXXXXXXXXXXXXXXXXXXX 1016
               F D  VR  A   +  +SDD+L  +LPQ  QAL++E Y                   
Sbjct: 947  DSKFADQEVRSLAVTWIEAISDDELTDLLPQFVQALKYEIYLNSSLVQ------------ 994

Query: 1017 XXXXFWLLVHSLPNIPQAPHQEFLGINLEDNASENAETDASMSASWRYTLMLRALLVICG 1076
                 +LL  +L NI  A +  +L   L+D     A  D   S   RY  +L ALL + G
Sbjct: 995  -----FLLSRALGNIQIAHNLYWL---LKD-----ALHDVQFST--RYEHVLGALLSVGG 1039

Query: 1077 ENLNKTLLRQQLLVKSLCEMAVSVKCAKEXXXXXXXXXXXXXXXXXXXXQPTALPLALHK 1136
            + L + LL+Q  LV+ L  +A  V+ A                          LPL    
Sbjct: 1040 KRLREELLKQTKLVQLLGGVAEKVRQASGSARQVVLQRSMERVQSFFQKNKCRLPLKPSL 1099

Query: 1137 YVHDLDVKSCTYFSSNTLPLKINFIGTD--NAVIPAMFKVGDDLRQDALVLQVIKIMDTL 1194
               +L++KSC++FSSN +PLK+  +  D     I  MFKVG+DLRQD L LQ+IKIMD +
Sbjct: 1100 VAKELNIKSCSFFSSNAVPLKVTMVNADPMGEEINVMFKVGEDLRQDMLALQMIKIMDKI 1159

Query: 1195 WLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQTEWGLTGSFKDKPIAEWLAKHN 1254
            WLK GLDLRMV F+ L T   +GM+E+V  ++TLR IQ E+G+TGSFKDKP+AEWL K+N
Sbjct: 1160 WLKEGLDLRMVIFKCLSTGRDRGMVELVPASDTLRKIQVEYGVTGSFKDKPLAEWLRKYN 1219

Query: 1255 PSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMF 1314
            PSE EY++A +NF  SCAG  VATY+LGICDRHNDNIML+++GH+FHIDFGKFLG AQMF
Sbjct: 1220 PSEEEYEKASENFIYSCAGCCVATYVLGICDRHNDNIMLRSTGHMFHIDFGKFLGHAQMF 1279

Query: 1315 GNFKRLVYIDRAPFVLTHDMVYVINGGERPTQRFQHFVELCCMAFNIVRAHHDHILDLFA 1374
            G+FKR    DRAPFVLT DM YVINGGE+PT RFQ FV+LCC A+N++R   +  L+L +
Sbjct: 1280 GSFKR----DRAPFVLTSDMAYVINGGEKPTIRFQLFVDLCCQAYNLIRKQTNLFLNLLS 1335

Query: 1375 LPSCDSGGSERTVAGGRPQMSLSGVPGVT--SAAVSYVRXXXXXXXXXXX----XXXXXX 1428
            L    SG  E T       +  +  P  T   A + + R                     
Sbjct: 1336 L-MIPSGLPELTSIQDLKYVRDALQPQTTDAEATIFFTRLIESSLGSIATKFNFFIHNLA 1394

Query: 1429 RLIHSSLKSN-------------MTQEGRLVSVECLGYEKRYDPEKHYVYALRIYRLGQA 1475
            +L  S L SN               Q+GR+  V    Y K+Y+P+KHY+Y +RI R GQ 
Sbjct: 1395 QLRFSGLPSNDEPILSFSPKTYSFRQDGRIKEVSVFTYHKKYNPDKHYIYVVRILREGQI 1454

Query: 1476 TPSVLYRSYKHFTELYQKICLHFPLAKV 1503
             PS ++R++  F EL+ K+ + FPL K+
Sbjct: 1455 EPSFVFRTFDEFQELHNKLSIIFPLWKL 1482


>Y13367-1|CAA73797.1| 1686|Homo sapiens phosphoinositide 3-kinase
            protein.
          Length = 1686

 Score =  535 bits (1321), Expect = e-151
 Identities = 380/1168 (32%), Positives = 573/1168 (49%), Gaps = 92/1168 (7%)

Query: 365  DSEHKAFLKMALDVRKKFVYTDERTNPGHVIAARSGGKY--PPNTSIKILVHHAHSDEPI 422
            + E  AF +    ++ KF YT+ RTNPG++++  +  +     N S+K+ +       P+
Sbjct: 378  NEEMAAFCRSITKLKTKFPYTNHRTNPGYLLSPVTAQRNICGENASVKVSIDIEGFQLPV 437

Query: 423  TFTSDVESKVEHVILTVVCSLDEDIRE-DMSGYMLRVRGAKEYLTPGSSLSEYDYIRECV 481
            TFT DV S VE +I+  +C + +D+ + D+  Y+L+V G +E L     L  +++I+ C 
Sbjct: 438  TFTCDVSSTVEIIIMQALCWVHDDLNQVDVGSYVLKVCGQEEVLQNNHCLGSHEHIQNCR 497

Query: 482  RLEKDVTLCL--HEGRDSTLARTERDDAKDSHLTLDDLFPAQGATPMLSFDNLSILLETL 539
            + + ++ L L         LART  DD     L        +     ++   +  LL++ 
Sbjct: 498  KWDTEIRLQLLTFSAMCQNLARTAEDDETPVDLNKHLYQIEKPCKEAMTRHPVEELLDSY 557

Query: 540  EGELSRAIGVTSAEGSCSPKAVFQAVKAICALAGGVETLHVTHTLNAFAQACTAQGANNV 599
              ++  A+ + +   +     V +AV+ IC+   GVETL +T ++    +A       N+
Sbjct: 558  HNQVELALQIENQHRAVDQ--VIKAVRKICSALDGVETLAITESVKKLKRAV------NL 609

Query: 600  VRPEIEREQGAYCSVSLAAGSRRDCVSLQGGRVRDAVXXXXXXXXXXXXXDFRLADAHYQ 659
             R +       +     +  S R  ++ +   V+ ++                   +   
Sbjct: 610  PRSKTADVTSLFGGEDTSRSSTRGSLNPENP-VQVSINQLTAAIYDLLRLHANSGRSPTD 668

Query: 660  APANPAKAVPAHTISETTLFCIEAVHCLPLCW--SHDEYMFHAQIYHGTRPLKTLRFTQA 717
               +      A T +E   F I A H +   W  ++++Y     + H  + L   +  Q+
Sbjct: 669  CAQSSKSVKEAWTTTEQLQFTIFAAHGISSNWVSNYEKYYLICSLSHNGKDL--FKPIQS 726

Query: 718  SKIEC-GGFYPRIIFDTWLNLEDLPVNTLPRESRLVLTLHGRTQRTIDSQHPNENSPPSS 776
             K+     F+  I +D  L +  + ++ LP ES L LTL G   ++  S  P+ N     
Sbjct: 727  KKVGTYKNFFYLIKWDE-LIIFPIQISQLPLESVLHLTLFGILNQSSGSS-PDSNKQRKG 784

Query: 777  QEAEDSGDVLYEQVELGWAALQLFDFDGMLSSGNYVLPLWPTSCDRRXXXXXXXXXXXXX 836
             EA            LG  +L L DF   L+ G  +L LW TS                 
Sbjct: 785  PEA------------LGKVSLPLCDFRRFLTCGTKLLYLW-TSSHTNSVPGTVTKKGYVM 831

Query: 837  XXXVVNIEIPLYAHTGVKWTSGEEDKQKNISLKDLPSFDSLDGHTQSQLLHLIEQGAYQR 896
               V+ ++ P  A   + +T+ + D+    S+    + ++L+   + +LL ++ + +   
Sbjct: 832  ERIVLQVDFPSPAFD-IIYTTPQVDR----SIIQQHNLETLENDIKGKLLDILHKDSSLG 886

Query: 897  MPTECREVMWEKRQYLVQIPGALPLVLLAATNWYGDHREQLIGLLRLWEKPSPLNAMHLL 956
            +  E +  +WEKR Y  + P  LP +L +A NW   +  +   LL  W    PL A+ LL
Sbjct: 887  LSKEDKAFLWEKRYYCFKHPNCLPKILASAPNWKWGNLAKTYSLLHQWPALYPLIALELL 946

Query: 957  LPCFPDVAVRETAAKLLNEMSDDDLCRVLPQLTQALRHETYXXXXXXXXXXXXXXXXXXX 1016
               F D  VR  A   +  +SDD+L  +LPQ  QAL++E Y                   
Sbjct: 947  DSKFADQEVRSLAVTWIEAISDDELTDLLPQFVQALKYEIYLNSSLVQ------------ 994

Query: 1017 XXXXFWLLVHSLPNIPQAPHQEFLGINLEDNASENAETDASMSASWRYTLMLRALLVICG 1076
                 +LL  +L NI  A +  +L   L+D     A  D   S   RY  +L ALL + G
Sbjct: 995  -----FLLSRALGNIQIAHNLYWL---LKD-----ALHDVQFST--RYEHVLGALLSVGG 1039

Query: 1077 ENLNKTLLRQQLLVKSLCEMAVSVKCAKEXXXXXXXXXXXXXXXXXXXXQPTALPLALHK 1136
            + L + LL+Q  LV+ L  +A  V+ A                          LPL    
Sbjct: 1040 KRLREELLKQTKLVQLLGGVAEKVRQASGSARQVVLQRSMERVQSFFQKNKCRLPLKPSL 1099

Query: 1137 YVHDLDVKSCTYFSSNTLPLKINFIGTD--NAVIPAMFKVGDDLRQDALVLQVIKIMDTL 1194
               +L++KSC++FSSN +PLK+  +  D     I  MFKVG+DLRQD L LQ+IKIMD +
Sbjct: 1100 VAKELNIKSCSFFSSNAVPLKVTMVNADPLGEEINVMFKVGEDLRQDMLALQMIKIMDKI 1159

Query: 1195 WLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQTEWGLTGSFKDKPIAEWLAKHN 1254
            WLK GLDLRMV F+ L T   +GM+E+V  ++TLR IQ E+G+TGSFKDKP+AEWL K+N
Sbjct: 1160 WLKEGLDLRMVIFKCLSTGRDRGMVELVPASDTLRKIQVEYGVTGSFKDKPLAEWLRKYN 1219

Query: 1255 PSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMF 1314
            PSE EY++A +NF  SCAG  VATY+LGICDRHNDNIML+++GH+FHIDFGKFLG AQMF
Sbjct: 1220 PSEEEYEKASENFIYSCAGCCVATYVLGICDRHNDNIMLRSTGHMFHIDFGKFLGHAQMF 1279

Query: 1315 GNFKRLVYIDRAPFVLTHDMVYVINGGERPTQRFQHFVELCCMAFNIVRAHHDHILDLFA 1374
            G+FKR    DRAPFVLT DM YVINGGE+PT RFQ FV+LCC A+N++R   +  L+L +
Sbjct: 1280 GSFKR----DRAPFVLTSDMAYVINGGEKPTIRFQLFVDLCCQAYNLIRKQTNLFLNLLS 1335

Query: 1375 LPSCDSGGSERTVAGGRPQMSLSGVPGVT--SAAVSYVRXXXXXXXXXXX----XXXXXX 1428
            L    SG  E T       +  +  P  T   A + + R                     
Sbjct: 1336 L-MIPSGLPELTSIQDLKYVRDALQPQTTDAEATIFFTRLIESSLGSIATKFNFFIHNLA 1394

Query: 1429 RLIHSSLKSN-------------MTQEGRLVSVECLGYEKRYDPEKHYVYALRIYRLGQA 1475
            +L  S L SN               Q+GR+  V    Y K+Y+P+KHY+Y +RI   GQ 
Sbjct: 1395 QLRFSGLPSNDEPILSFSPKTYSFRQDGRIKEVSVFTYHKKYNPDKHYIYVVRILWEGQI 1454

Query: 1476 TPSVLYRSYKHFTELYQKICLHFPLAKV 1503
             PS ++R++  F EL+ K+ + FPL K+
Sbjct: 1455 EPSFVFRTFVEFQELHNKLSIIFPLWKL 1482


>BC132876-1|AAI32877.1| 1634|Homo sapiens phosphoinositide-3-kinase,
            class 2, beta polypeptide protein.
          Length = 1634

 Score =  475 bits (1170), Expect = e-133
 Identities = 364/1163 (31%), Positives = 540/1163 (46%), Gaps = 102/1163 (8%)

Query: 365  DSEHKAFLKMALDVRKKFVYTDERTNPGHVIAA--RSGGKYPPNTSIKILVHHAHSDEPI 422
            D E  AF  M LD+ +      +    G+V +A   S        ++K+ V      E +
Sbjct: 333  DEEVAAFCHM-LDILRSGSDIQDYFLTGYVWSAVTPSPEHLGDEVNLKVTVLCDRLQEAL 391

Query: 423  TFTSDVESKVEHVILTVVCSLDEDIRE-DMSGYMLRVRGAKEYLTPGSSLSEYDYIRECV 481
            TFT +  S V+ +I   +C   +D+R  D+  ++L+  G +E+L    +L  ++YI+ C 
Sbjct: 392  TFTCNCSSTVDLLIYQTLCYTHDDLRNVDVGDFVLKPCGLEEFLQNKHALGSHEYIQYCR 451

Query: 482  RLEKDVTLCLHEGR--DSTLARTERDDAKDSHLTLDDLFPAQGATPMLSFDNLSILLETL 539
            + + D+ L L E +   S LART  DD   S L        +     +S   LS+L +T 
Sbjct: 452  KFDIDIRLQLMEQKVVRSDLARTVNDDQSPSTLNYLVHLQERPVKQTISRQALSLLFDTY 511

Query: 540  EGELSRAIGVTSAEGSCSPKA--VFQAVKAICALAGGVETLHVTHTLNAFAQACTAQGAN 597
              E+   +    A+G    KA  V Q+VKAIC     VET  +T  LN     C ++   
Sbjct: 512  HNEVDAFL---LADGDFPLKADRVVQSVKAICNALAAVETPEITSALNQLPP-CPSR--- 564

Query: 598  NVVRPEIEREQGAYCSVSLAAGSRRDCVSLQGGRVRDAVXXXXXXXXXXXXXDFRLADAH 657
              ++P+I+++     SV     +R   V      + D V             DF+ A   
Sbjct: 565  --MQPKIQKDP----SVLAVRENREKVVEALTAAILDLVELYCNTFNA----DFQTAVPG 614

Query: 658  YQAPANPAKAVPAHTISETTLFCIEAVHCLPLCW--SHDEYMFHAQIYHGTRPLKTLRFT 715
             +      +A   H  + +  F + A H +P+ W  S++++     + HG + L +   T
Sbjct: 615  SRKHDLVQEA--CH-FARSLAFTVYATHRIPIIWATSYEDFYLSCSLSHGGKELCSPLQT 671

Query: 716  QASKIECGGFYPRIIFDTWLNLEDLPVNTLPRESRLVLTLHGRTQRTIDSQHPNENSPPS 775
            + +      F+  I++D  +    + VN LPRE+ L  TL+                P S
Sbjct: 672  RRAHFSKYLFH-LIVWDQQICFP-VQVNRLPRETLLCATLYALPIPP----------PGS 719

Query: 776  SQEAEDSGDVLYEQVELGWAALQLFDFDGMLSSGNYVLPLWPTSCDRRXXXXXXXXXXXX 835
            S EA     V      LGW    LF+F  +L+ G  +L LWP +                
Sbjct: 720  SSEANKQRRV---PEALGWVTTPLFNFRQVLTCGRKLLGLWPAT-QENPSARWSAPNFHQ 775

Query: 836  XXXXVVNIEIPLYAHTGVKWTSGEEDKQKNISLKDLPSFDSLDGHTQSQLLHLIEQGAYQ 895
                ++ I+ P  A   +K+TS   DK           F SL    Q +L  ++++ +  
Sbjct: 776  PDSVILQIDFPTSAFD-IKFTSPPGDK-----FSPRYEFGSLREEDQRKLKDIMQKESLY 829

Query: 896  RMPTECREVMWEKRQYLVQIPGALPLVLLAATNWYGDHREQLIGLLRLWEKPSPLNAMHL 955
             +    ++ +WEKR Y      +LPLVL +A +W       +  LL+ W   +  +A+ L
Sbjct: 830  WLTDADKKRLWEKRYYCHSEVSSLPLVLASAPSWEWACLPDIYVLLKQWTHMNHQDALGL 889

Query: 956  LLPCFPDVAVRETAAKLLNEMSDDDLCRVLPQLTQALRHETYXXXXXXXXXXXXXXXXXX 1015
            L   FPD  VR  A + +  +SD +L   LPQL QAL++E Y                  
Sbjct: 890  LHATFPDQEVRRMAVQWIGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLR 949

Query: 1016 XXXXXFWLLVHSLPNIPQAPHQEFLGINLEDNASENAETDASMSASWRYTLMLRALLVIC 1075
                 FWL                    L+D   ++         S RY  +L ALL  C
Sbjct: 950  VTHYFFWL--------------------LKDGLKDS-------QFSIRYQYLLAALLCCC 982

Query: 1076 GENLNKTLLRQQLLVKSLCEMAVSVKCAKEXXXXXXXXXXXXXXXXXXXXQPTA-LPLAL 1134
            G+ L +   RQ  LV +L ++A  V+ A                        +  LPL+ 
Sbjct: 983  GKGLREEFNRQCWLVNALAKLAQQVREAAPSARQGILRTGLEEVKQFFALNGSCRLPLSP 1042

Query: 1135 HKYVHDLDVKSCTYFSSNTLPLKINFIGTD--NAVIPAMFKVGDDLRQDALVLQVIKIMD 1192
               V  +  + C+YF+SN +PLK++F   D     I  +FK GDDLRQD L LQ+I+IM 
Sbjct: 1043 SLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRVIFKCGDDLRQDMLTLQMIRIMS 1102

Query: 1193 TLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQTEWGLTGSFKDKPIAEWLAK 1252
             +W++ GLD+RMV F+   T   +GM+E++  AETLR IQ E G+TGSFKD+P+A+WL K
Sbjct: 1103 KIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEHGVTGSFKDRPLADWLQK 1162

Query: 1253 HNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQ 1312
            HNP E EY++A +NF  SCAG  VATY+LGICDRHNDNIMLKT+GH+FHIDFG+FLG AQ
Sbjct: 1163 HNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQ 1222

Query: 1313 MFGNFKRLVYIDRAPFVLTHDMVYVINGGERPTQRFQHFVELCCMAFNIVRAHHDHILDL 1372
            MFGN KR    DRAPFV T DM YVINGG++P+ RF  FV+LCC A+N++R H    L+L
Sbjct: 1223 MFGNIKR----DRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLFLNL 1278

Query: 1373 FALP-SC---------------DSGGSERTVAGGRPQMSLSGVPGVTSAAVSYVRXXXXX 1416
              L  SC               D+   + T A      +      + S A          
Sbjct: 1279 LGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLIESSLGSVATKLNFFIHNL 1338

Query: 1417 XXXXXXXXXXXXRLIHSSLKSNMTQEGRLVSVECLGYEKRYDPEKHYVYALRIYRLGQAT 1476
                         L  +S    +   GR+  V    +EK + P K Y+Y +++ R     
Sbjct: 1339 AQMKFTGSDDRLTLSFASRTHTLKSSGRISDVFLCRHEKIFHPNKGYIYVVKVMRENTHE 1398

Query: 1477 PSVLYRSYKHFTELYQKICLHFP 1499
             + + R+++ F EL+ K+ L FP
Sbjct: 1399 ATYIQRTFEEFQELHNKLRLLFP 1421


>AL606489-4|CAI16572.1| 1634|Homo sapiens phosphoinositide-3-kinase,
            class 2, beta polypeptide protein.
          Length = 1634

 Score =  475 bits (1170), Expect = e-133
 Identities = 364/1163 (31%), Positives = 540/1163 (46%), Gaps = 102/1163 (8%)

Query: 365  DSEHKAFLKMALDVRKKFVYTDERTNPGHVIAA--RSGGKYPPNTSIKILVHHAHSDEPI 422
            D E  AF  M LD+ +      +    G+V +A   S        ++K+ V      E +
Sbjct: 333  DEEVAAFCHM-LDILRSGSDIQDYFLTGYVWSAVTPSPEHLGDEVNLKVTVLCDRLQEAL 391

Query: 423  TFTSDVESKVEHVILTVVCSLDEDIRE-DMSGYMLRVRGAKEYLTPGSSLSEYDYIRECV 481
            TFT +  S V+ +I   +C   +D+R  D+  ++L+  G +E+L    +L  ++YI+ C 
Sbjct: 392  TFTCNCSSTVDLLIYQTLCYTHDDLRNVDVGDFVLKPCGLEEFLQNKHALGSHEYIQYCR 451

Query: 482  RLEKDVTLCLHEGR--DSTLARTERDDAKDSHLTLDDLFPAQGATPMLSFDNLSILLETL 539
            + + D+ L L E +   S LART  DD   S L        +     +S   LS+L +T 
Sbjct: 452  KFDIDIRLQLMEQKVVRSDLARTVNDDQSPSTLNYLVHLQERPVKQTISRQALSLLFDTY 511

Query: 540  EGELSRAIGVTSAEGSCSPKA--VFQAVKAICALAGGVETLHVTHTLNAFAQACTAQGAN 597
              E+   +    A+G    KA  V Q+VKAIC     VET  +T  LN     C ++   
Sbjct: 512  HNEVDAFL---LADGDFPLKADRVVQSVKAICNALAAVETPEITSALNQLPP-CPSR--- 564

Query: 598  NVVRPEIEREQGAYCSVSLAAGSRRDCVSLQGGRVRDAVXXXXXXXXXXXXXDFRLADAH 657
              ++P+I+++     SV     +R   V      + D V             DF+ A   
Sbjct: 565  --MQPKIQKDP----SVLAVRENREKVVEALTAAILDLVELYCNTFNA----DFQTAVPG 614

Query: 658  YQAPANPAKAVPAHTISETTLFCIEAVHCLPLCW--SHDEYMFHAQIYHGTRPLKTLRFT 715
             +      +A   H  + +  F + A H +P+ W  S++++     + HG + L +   T
Sbjct: 615  SRKHDLVQEA--CH-FARSLAFTVYATHRIPIIWATSYEDFYLSCSLSHGGKELCSPLQT 671

Query: 716  QASKIECGGFYPRIIFDTWLNLEDLPVNTLPRESRLVLTLHGRTQRTIDSQHPNENSPPS 775
            + +      F+  I++D  +    + VN LPRE+ L  TL+                P S
Sbjct: 672  RRAHFSKYLFH-LIVWDQQICFP-VQVNRLPRETLLCATLYALPIPP----------PGS 719

Query: 776  SQEAEDSGDVLYEQVELGWAALQLFDFDGMLSSGNYVLPLWPTSCDRRXXXXXXXXXXXX 835
            S EA     V      LGW    LF+F  +L+ G  +L LWP +                
Sbjct: 720  SSEANKQRRV---PEALGWVTTPLFNFRQVLTCGRKLLGLWPAT-QENPSARWSAPNFHQ 775

Query: 836  XXXXVVNIEIPLYAHTGVKWTSGEEDKQKNISLKDLPSFDSLDGHTQSQLLHLIEQGAYQ 895
                ++ I+ P  A   +K+TS   DK           F SL    Q +L  ++++ +  
Sbjct: 776  PDSVILQIDFPTSAFD-IKFTSPPGDK-----FSPRYEFGSLREEDQRKLKDIMQKESLY 829

Query: 896  RMPTECREVMWEKRQYLVQIPGALPLVLLAATNWYGDHREQLIGLLRLWEKPSPLNAMHL 955
             +    ++ +WEKR Y      +LPLVL +A +W       +  LL+ W   +  +A+ L
Sbjct: 830  WLTDADKKRLWEKRYYCHSEVSSLPLVLASAPSWEWACLPDIYVLLKQWTHMNHQDALGL 889

Query: 956  LLPCFPDVAVRETAAKLLNEMSDDDLCRVLPQLTQALRHETYXXXXXXXXXXXXXXXXXX 1015
            L   FPD  VR  A + +  +SD +L   LPQL QAL++E Y                  
Sbjct: 890  LHATFPDQEVRRMAVQWIGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLR 949

Query: 1016 XXXXXFWLLVHSLPNIPQAPHQEFLGINLEDNASENAETDASMSASWRYTLMLRALLVIC 1075
                 FWL                    L+D   ++         S RY  +L ALL  C
Sbjct: 950  VTHYFFWL--------------------LKDGLKDS-------QFSIRYQYLLAALLCCC 982

Query: 1076 GENLNKTLLRQQLLVKSLCEMAVSVKCAKEXXXXXXXXXXXXXXXXXXXXQPTA-LPLAL 1134
            G+ L +   RQ  LV +L ++A  V+ A                        +  LPL+ 
Sbjct: 983  GKGLREEFNRQCWLVNALAKLAQQVREAAPSARQGILRTGLEEVKQFFALNGSCRLPLSP 1042

Query: 1135 HKYVHDLDVKSCTYFSSNTLPLKINFIGTD--NAVIPAMFKVGDDLRQDALVLQVIKIMD 1192
               V  +  + C+YF+SN +PLK++F   D     I  +FK GDDLRQD L LQ+I+IM 
Sbjct: 1043 SLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRVIFKCGDDLRQDMLTLQMIRIMS 1102

Query: 1193 TLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQTEWGLTGSFKDKPIAEWLAK 1252
             +W++ GLD+RMV F+   T   +GM+E++  AETLR IQ E G+TGSFKD+P+A+WL K
Sbjct: 1103 KIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEHGVTGSFKDRPLADWLQK 1162

Query: 1253 HNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQ 1312
            HNP E EY++A +NF  SCAG  VATY+LGICDRHNDNIMLKT+GH+FHIDFG+FLG AQ
Sbjct: 1163 HNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQ 1222

Query: 1313 MFGNFKRLVYIDRAPFVLTHDMVYVINGGERPTQRFQHFVELCCMAFNIVRAHHDHILDL 1372
            MFGN KR    DRAPFV T DM YVINGG++P+ RF  FV+LCC A+N++R H    L+L
Sbjct: 1223 MFGNIKR----DRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLFLNL 1278

Query: 1373 FALP-SC---------------DSGGSERTVAGGRPQMSLSGVPGVTSAAVSYVRXXXXX 1416
              L  SC               D+   + T A      +      + S A          
Sbjct: 1279 LGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLIESSLGSVATKLNFFIHNL 1338

Query: 1417 XXXXXXXXXXXXRLIHSSLKSNMTQEGRLVSVECLGYEKRYDPEKHYVYALRIYRLGQAT 1476
                         L  +S    +   GR+  V    +EK + P K Y+Y +++ R     
Sbjct: 1339 AQMKFTGSDDRLTLSFASRTHTLKSSGRISDVFLCRHEKIFHPNKGYIYVVKVMRENTHE 1398

Query: 1477 PSVLYRSYKHFTELYQKICLHFP 1499
             + + R+++ F EL+ K+ L FP
Sbjct: 1399 ATYIQRTFEEFQELHNKLRLLFP 1421


>AB210006-1|BAE06088.1| 1645|Homo sapiens PIK3C2B variant protein
            protein.
          Length = 1645

 Score =  475 bits (1170), Expect = e-133
 Identities = 364/1163 (31%), Positives = 540/1163 (46%), Gaps = 102/1163 (8%)

Query: 365  DSEHKAFLKMALDVRKKFVYTDERTNPGHVIAA--RSGGKYPPNTSIKILVHHAHSDEPI 422
            D E  AF  M LD+ +      +    G+V +A   S        ++K+ V      E +
Sbjct: 344  DEEVAAFCHM-LDILRSGSDIQDYFLTGYVWSAVTPSPEHLGDEVNLKVTVLCDRLQEAL 402

Query: 423  TFTSDVESKVEHVILTVVCSLDEDIRE-DMSGYMLRVRGAKEYLTPGSSLSEYDYIRECV 481
            TFT +  S V+ +I   +C   +D+R  D+  ++L+  G +E+L    +L  ++YI+ C 
Sbjct: 403  TFTCNCSSTVDLLIYQTLCYTHDDLRNVDVGDFVLKPCGLEEFLQNKHALGSHEYIQYCR 462

Query: 482  RLEKDVTLCLHEGR--DSTLARTERDDAKDSHLTLDDLFPAQGATPMLSFDNLSILLETL 539
            + + D+ L L E +   S LART  DD   S L        +     +S   LS+L +T 
Sbjct: 463  KFDIDIRLQLMEQKVVRSDLARTVNDDQSPSTLNYLVHLQERPVKQTISRQALSLLFDTY 522

Query: 540  EGELSRAIGVTSAEGSCSPKA--VFQAVKAICALAGGVETLHVTHTLNAFAQACTAQGAN 597
              E+   +    A+G    KA  V Q+VKAIC     VET  +T  LN     C ++   
Sbjct: 523  HNEVDAFL---LADGDFPLKADRVVQSVKAICNALAAVETPEITSALNQLPP-CPSR--- 575

Query: 598  NVVRPEIEREQGAYCSVSLAAGSRRDCVSLQGGRVRDAVXXXXXXXXXXXXXDFRLADAH 657
              ++P+I+++     SV     +R   V      + D V             DF+ A   
Sbjct: 576  --MQPKIQKDP----SVLAVRENREKVVEALTAAILDLVELYCNTFNA----DFQTAVPG 625

Query: 658  YQAPANPAKAVPAHTISETTLFCIEAVHCLPLCW--SHDEYMFHAQIYHGTRPLKTLRFT 715
             +      +A   H  + +  F + A H +P+ W  S++++     + HG + L +   T
Sbjct: 626  SRKHDLVQEA--CH-FARSLAFTVYATHRIPIIWATSYEDFYLSCSLSHGGKELCSPLQT 682

Query: 716  QASKIECGGFYPRIIFDTWLNLEDLPVNTLPRESRLVLTLHGRTQRTIDSQHPNENSPPS 775
            + +      F+  I++D  +    + VN LPRE+ L  TL+                P S
Sbjct: 683  RRAHFSKYLFH-LIVWDQQICFP-VQVNRLPRETLLCATLYALPIPP----------PGS 730

Query: 776  SQEAEDSGDVLYEQVELGWAALQLFDFDGMLSSGNYVLPLWPTSCDRRXXXXXXXXXXXX 835
            S EA     V      LGW    LF+F  +L+ G  +L LWP +                
Sbjct: 731  SSEANKQRRV---PEALGWVTTPLFNFRQVLTCGRKLLGLWPAT-QENPSARWSAPNFHQ 786

Query: 836  XXXXVVNIEIPLYAHTGVKWTSGEEDKQKNISLKDLPSFDSLDGHTQSQLLHLIEQGAYQ 895
                ++ I+ P  A   +K+TS   DK           F SL    Q +L  ++++ +  
Sbjct: 787  PDSVILQIDFPTSAFD-IKFTSPPGDK-----FSPRYEFGSLREEDQRKLKDIMQKESLY 840

Query: 896  RMPTECREVMWEKRQYLVQIPGALPLVLLAATNWYGDHREQLIGLLRLWEKPSPLNAMHL 955
             +    ++ +WEKR Y      +LPLVL +A +W       +  LL+ W   +  +A+ L
Sbjct: 841  WLTDADKKRLWEKRYYCHSEVSSLPLVLASAPSWEWACLPDIYVLLKQWTHMNHQDALGL 900

Query: 956  LLPCFPDVAVRETAAKLLNEMSDDDLCRVLPQLTQALRHETYXXXXXXXXXXXXXXXXXX 1015
            L   FPD  VR  A + +  +SD +L   LPQL QAL++E Y                  
Sbjct: 901  LHATFPDQEVRRMAVQWIGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLR 960

Query: 1016 XXXXXFWLLVHSLPNIPQAPHQEFLGINLEDNASENAETDASMSASWRYTLMLRALLVIC 1075
                 FWL                    L+D   ++         S RY  +L ALL  C
Sbjct: 961  VTHYFFWL--------------------LKDGLKDS-------QFSIRYQYLLAALLCCC 993

Query: 1076 GENLNKTLLRQQLLVKSLCEMAVSVKCAKEXXXXXXXXXXXXXXXXXXXXQPTA-LPLAL 1134
            G+ L +   RQ  LV +L ++A  V+ A                        +  LPL+ 
Sbjct: 994  GKGLREEFNRQCWLVNALAKLAQQVREAAPSARQGILRTGLEEVKQFFALNGSCRLPLSP 1053

Query: 1135 HKYVHDLDVKSCTYFSSNTLPLKINFIGTD--NAVIPAMFKVGDDLRQDALVLQVIKIMD 1192
               V  +  + C+YF+SN +PLK++F   D     I  +FK GDDLRQD L LQ+I+IM 
Sbjct: 1054 SLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRVIFKCGDDLRQDMLTLQMIRIMS 1113

Query: 1193 TLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQTEWGLTGSFKDKPIAEWLAK 1252
             +W++ GLD+RMV F+   T   +GM+E++  AETLR IQ E G+TGSFKD+P+A+WL K
Sbjct: 1114 KIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEHGVTGSFKDRPLADWLQK 1173

Query: 1253 HNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQ 1312
            HNP E EY++A +NF  SCAG  VATY+LGICDRHNDNIMLKT+GH+FHIDFG+FLG AQ
Sbjct: 1174 HNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQ 1233

Query: 1313 MFGNFKRLVYIDRAPFVLTHDMVYVINGGERPTQRFQHFVELCCMAFNIVRAHHDHILDL 1372
            MFGN KR    DRAPFV T DM YVINGG++P+ RF  FV+LCC A+N++R H    L+L
Sbjct: 1234 MFGNIKR----DRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLFLNL 1289

Query: 1373 FALP-SC---------------DSGGSERTVAGGRPQMSLSGVPGVTSAAVSYVRXXXXX 1416
              L  SC               D+   + T A      +      + S A          
Sbjct: 1290 LGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLIESSLGSVATKLNFFIHNL 1349

Query: 1417 XXXXXXXXXXXXRLIHSSLKSNMTQEGRLVSVECLGYEKRYDPEKHYVYALRIYRLGQAT 1476
                         L  +S    +   GR+  V    +EK + P K Y+Y +++ R     
Sbjct: 1350 AQMKFTGSDDRLTLSFASRTHTLKSSGRISDVFLCRHEKIFHPNKGYIYVVKVMRENTHE 1409

Query: 1477 PSVLYRSYKHFTELYQKICLHFP 1499
             + + R+++ F EL+ K+ L FP
Sbjct: 1410 ATYIQRTFEEFQELHNKLRLLFP 1432


>Y11312-1|CAA72168.1| 1634|Homo sapiens phosphoinositide 3-kinase
            protein.
          Length = 1634

 Score =  474 bits (1168), Expect = e-132
 Identities = 363/1163 (31%), Positives = 540/1163 (46%), Gaps = 102/1163 (8%)

Query: 365  DSEHKAFLKMALDVRKKFVYTDERTNPGHVIAA--RSGGKYPPNTSIKILVHHAHSDEPI 422
            D E  AF  M LD+ +      +    G+V +A   S        ++K+ V      E +
Sbjct: 333  DEEVAAFCHM-LDILRSGSDIQDYFLTGYVWSAVTPSPEHLGDEVNLKVTVLCDRLQEAL 391

Query: 423  TFTSDVESKVEHVILTVVCSLDEDIRE-DMSGYMLRVRGAKEYLTPGSSLSEYDYIRECV 481
            TFT +  S V+ +I   +C   +D+R  D+  ++L+  G +E+L    +L  ++YI+ C 
Sbjct: 392  TFTCNCSSTVDLLIYQTLCYTHDDLRNVDVGDFVLKPCGLEEFLQNKHALGSHEYIQYCR 451

Query: 482  RLEKDVTLCLHEGR--DSTLARTERDDAKDSHLTLDDLFPAQGATPMLSFDNLSILLETL 539
            + + D+ L L E +   S LART  DD   S L        +     +S   LS+L +T 
Sbjct: 452  KFDIDIRLQLMEQKVVRSDLARTVNDDQSPSTLNYLVHLQERPVKQTISRQALSLLFDTY 511

Query: 540  EGELSRAIGVTSAEGSCSPKA--VFQAVKAICALAGGVETLHVTHTLNAFAQACTAQGAN 597
              E+   +    A+G    KA  V Q+VKAIC     VET  +T  LN     C ++   
Sbjct: 512  HNEVDAFL---LADGDFPLKADRVVQSVKAICNALAAVETPEITSALNQLPP-CPSR--- 564

Query: 598  NVVRPEIEREQGAYCSVSLAAGSRRDCVSLQGGRVRDAVXXXXXXXXXXXXXDFRLADAH 657
              ++P+I+++     SV     +R   V      + D V             DF+ A   
Sbjct: 565  --MQPKIQKDP----SVLAVRENREKVVEALTAAILDLVELYCNTFNA----DFQTAVPG 614

Query: 658  YQAPANPAKAVPAHTISETTLFCIEAVHCLPLCW--SHDEYMFHAQIYHGTRPLKTLRFT 715
             +      +A   H  + +  F + A H +P+ W  S++++     + HG + + +   T
Sbjct: 615  SRKHDLVQEA--CH-FARSLAFTVYATHRIPIIWATSYEDFYLSCSLSHGGKDMCSPLQT 671

Query: 716  QASKIECGGFYPRIIFDTWLNLEDLPVNTLPRESRLVLTLHGRTQRTIDSQHPNENSPPS 775
            + +      F+  I++D  +    + VN LPRE+ L  TL+                P S
Sbjct: 672  RRAHFSKYLFH-LIVWDQQICFP-VQVNRLPRETLLCATLYALPIPP----------PGS 719

Query: 776  SQEAEDSGDVLYEQVELGWAALQLFDFDGMLSSGNYVLPLWPTSCDRRXXXXXXXXXXXX 835
            S EA     V      LGW    LF+F  +L+ G  +L LWP +                
Sbjct: 720  SSEANKQRRV---PEALGWVTTPLFNFRQVLTCGRKLLGLWPAT-QENPSARWSAPNFHQ 775

Query: 836  XXXXVVNIEIPLYAHTGVKWTSGEEDKQKNISLKDLPSFDSLDGHTQSQLLHLIEQGAYQ 895
                ++ I+ P  A   +K+TS   DK           F SL    Q +L  ++++ +  
Sbjct: 776  PDSVILQIDFPTSAFD-IKFTSPPGDK-----FSPRYEFGSLREEDQRKLKDIMQKESLY 829

Query: 896  RMPTECREVMWEKRQYLVQIPGALPLVLLAATNWYGDHREQLIGLLRLWEKPSPLNAMHL 955
             +    ++ +WEKR Y      +LPLVL +A +W       +  LL+ W   +  +A+ L
Sbjct: 830  WLTDADKKRLWEKRYYCHSEVSSLPLVLASAPSWEWACLPDIYVLLKQWTHMNHQDALGL 889

Query: 956  LLPCFPDVAVRETAAKLLNEMSDDDLCRVLPQLTQALRHETYXXXXXXXXXXXXXXXXXX 1015
            L   FPD  VR  A + +  +SD +L   LPQL QAL++E Y                  
Sbjct: 890  LHATFPDQEVRRMAVQWIGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLR 949

Query: 1016 XXXXXFWLLVHSLPNIPQAPHQEFLGINLEDNASENAETDASMSASWRYTLMLRALLVIC 1075
                 FWL                    L+D   ++         S RY  +L ALL  C
Sbjct: 950  VTHYFFWL--------------------LKDGLKDS-------QFSIRYQYLLAALLCCC 982

Query: 1076 GENLNKTLLRQQLLVKSLCEMAVSVKCAKEXXXXXXXXXXXXXXXXXXXXQPTA-LPLAL 1134
            G+ L +   RQ  LV +L ++A  V+ A                        +  LPL+ 
Sbjct: 983  GKGLREEFNRQCWLVNALAKLAQQVREAAPSARQGILRTGLEEVKQFFALNGSCRLPLSP 1042

Query: 1135 HKYVHDLDVKSCTYFSSNTLPLKINFIGTD--NAVIPAMFKVGDDLRQDALVLQVIKIMD 1192
               V  +  + C+YF+SN +PLK++F   D     I  +FK GDDLRQD L LQ+I+IM 
Sbjct: 1043 SLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRVIFKCGDDLRQDMLTLQMIRIMS 1102

Query: 1193 TLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQTEWGLTGSFKDKPIAEWLAK 1252
             +W++ GLD+RMV F+   T   +GM+E++  AETLR IQ E G+TGSFKD+P+A+WL K
Sbjct: 1103 KIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEHGVTGSFKDRPLADWLQK 1162

Query: 1253 HNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQ 1312
            HNP E EY++A +NF  SCAG  VATY+LGICDRHNDNIMLKT+GH+FHIDFG+FLG AQ
Sbjct: 1163 HNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQ 1222

Query: 1313 MFGNFKRLVYIDRAPFVLTHDMVYVINGGERPTQRFQHFVELCCMAFNIVRAHHDHILDL 1372
            MFGN KR    DRAPFV T DM YVINGG++P+ RF  FV+LCC A+N++R H    L+L
Sbjct: 1223 MFGNIKR----DRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLFLNL 1278

Query: 1373 FALP-SC---------------DSGGSERTVAGGRPQMSLSGVPGVTSAAVSYVRXXXXX 1416
              L  SC               D+   + T A      +      + S A          
Sbjct: 1279 LGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLIESSLGSVATKLNFFIHNL 1338

Query: 1417 XXXXXXXXXXXXRLIHSSLKSNMTQEGRLVSVECLGYEKRYDPEKHYVYALRIYRLGQAT 1476
                         L  +S    +   GR+  V    +EK + P K Y+Y +++ R     
Sbjct: 1339 AQMKFTGSDDRLTLSFASRTHTLKSSGRISDVFLCRHEKIFHPNKGYIYVVKVMRENTHE 1398

Query: 1477 PSVLYRSYKHFTELYQKICLHFP 1499
             + + R+++ F EL+ K+ L FP
Sbjct: 1399 ATYIQRTFEEFQELHNKLRLLFP 1421


>Y13892-1|CAA74194.1| 1609|Homo sapiens PI-3 kinase protein.
          Length = 1609

 Score =  471 bits (1162), Expect = e-132
 Identities = 363/1163 (31%), Positives = 539/1163 (46%), Gaps = 102/1163 (8%)

Query: 365  DSEHKAFLKMALDVRKKFVYTDERTNPGHVIAA--RSGGKYPPNTSIKILVHHAHSDEPI 422
            D E  AF  M LD+ +      +    G+V +A   S        ++K+ V      E +
Sbjct: 308  DEEVAAFCHM-LDILRSGSDIQDYFLTGYVWSAVTPSPEHLGDEVNLKVTVLCDRLQEAL 366

Query: 423  TFTSDVESKVEHVILTVVCSLDEDIRE-DMSGYMLRVRGAKEYLTPGSSLSEYDYIRECV 481
            TFT +  S V+ +I   +C   +D+R  D+  ++L+  G +E+L    +L  ++YI+ C 
Sbjct: 367  TFTCNCSSTVDLLIYQTLCYTHDDLRNVDVGDFVLKPCGLEEFLQNKHALGSHEYIQYCR 426

Query: 482  RLEKDVTLCLHEGR--DSTLARTERDDAKDSHLTLDDLFPAQGATPMLSFDNLSILLETL 539
            + + D+ L L E +   S LART  DD   S L        +     +S   LS+L +T 
Sbjct: 427  KFDIDIRLQLMEQKVVRSDLARTVNDDQSPSTLNYLVHLQERPVKQTISRQALSLLFDTY 486

Query: 540  EGELSRAIGVTSAEGSCSPKA--VFQAVKAICALAGGVETLHVTHTLNAFAQACTAQGAN 597
              E+   +    A+G    KA  V Q+VKAIC     VET  +T  LN     C ++   
Sbjct: 487  HNEVDAFL---LADGDFPLKADRVVQSVKAICNALAAVETPEITSALNQLPP-CPSR--- 539

Query: 598  NVVRPEIEREQGAYCSVSLAAGSRRDCVSLQGGRVRDAVXXXXXXXXXXXXXDFRLADAH 657
              ++ +I+++     SV     +R   V      + D V             DF+ A   
Sbjct: 540  --MQSKIQKDP----SVLAVRENREKVVEALTAAILDLVELYCNTFNA----DFQTAVPG 589

Query: 658  YQAPANPAKAVPAHTISETTLFCIEAVHCLPLCW--SHDEYMFHAQIYHGTRPLKTLRFT 715
             +      +A   H  + +  F + A H +P+ W  S++++     + HG + L +   T
Sbjct: 590  SRKHDLVQEA--CH-FARSLAFTVYATHRIPIIWATSYEDFYLSCSLSHGGKELCSPLQT 646

Query: 716  QASKIECGGFYPRIIFDTWLNLEDLPVNTLPRESRLVLTLHGRTQRTIDSQHPNENSPPS 775
            + +      F+  I++D  +    + VN LPRE+ L  TL+                P S
Sbjct: 647  RRAHFSKYLFH-LIVWDQQICFP-VQVNRLPRETLLCATLYALPIPP----------PGS 694

Query: 776  SQEAEDSGDVLYEQVELGWAALQLFDFDGMLSSGNYVLPLWPTSCDRRXXXXXXXXXXXX 835
            S EA     V      LGW    LF+F  +L+ G  +L LWP +                
Sbjct: 695  SSEANKQRRV---PEALGWVTTPLFNFRQVLTCGRKLLGLWPAT-QENPSARWSAPNFHQ 750

Query: 836  XXXXVVNIEIPLYAHTGVKWTSGEEDKQKNISLKDLPSFDSLDGHTQSQLLHLIEQGAYQ 895
                ++ I+ P  A   +K+TS   DK           F SL    Q +L  ++++ +  
Sbjct: 751  PDSVILQIDFPTSAFD-IKFTSPPGDK-----FSPRYEFGSLREEDQRKLKDIMQKESLY 804

Query: 896  RMPTECREVMWEKRQYLVQIPGALPLVLLAATNWYGDHREQLIGLLRLWEKPSPLNAMHL 955
             +    ++ +WEKR Y      +LPLVL +A +W       +  LL+ W   +  +A+ L
Sbjct: 805  WLTDADKKRLWEKRYYCHSEVSSLPLVLASAPSWEWACLPDIYVLLKQWTHMNHQDALGL 864

Query: 956  LLPCFPDVAVRETAAKLLNEMSDDDLCRVLPQLTQALRHETYXXXXXXXXXXXXXXXXXX 1015
            L   FPD  VR  A + +  +SD +L   LPQL QAL++E Y                  
Sbjct: 865  LHATFPDQEVRRMAVQWIGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLR 924

Query: 1016 XXXXXFWLLVHSLPNIPQAPHQEFLGINLEDNASENAETDASMSASWRYTLMLRALLVIC 1075
                 FWL                    L+D   ++         S RY  +L ALL  C
Sbjct: 925  VTHYFFWL--------------------LKDGLKDS-------QFSIRYQYLLAALLCCC 957

Query: 1076 GENLNKTLLRQQLLVKSLCEMAVSVKCAKEXXXXXXXXXXXXXXXXXXXXQPTA-LPLAL 1134
            G+ L +   RQ  LV +L ++A  V+ A                        +  LPL+ 
Sbjct: 958  GKGLREEFNRQCWLVNALAKLAQQVREAAPSARQGILRTGLEEVKQFFALNGSCRLPLSP 1017

Query: 1135 HKYVHDLDVKSCTYFSSNTLPLKINFIGTD--NAVIPAMFKVGDDLRQDALVLQVIKIMD 1192
               V  +  + C+YF+SN +PLK++F   D     I  +FK GDDLRQD L LQ+I+IM 
Sbjct: 1018 SLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRVIFKCGDDLRQDMLTLQMIRIMS 1077

Query: 1193 TLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQTEWGLTGSFKDKPIAEWLAK 1252
             +W++ GLD+RMV F+   T   +GM+E++  AETLR IQ E G+TGSFKD+P+A+WL K
Sbjct: 1078 KIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEHGVTGSFKDRPLADWLQK 1137

Query: 1253 HNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQ 1312
            HNP E EY++A +NF  SCAG  VATY+LGICDRHNDNIMLKT+GH+FHIDFG+FLG AQ
Sbjct: 1138 HNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQ 1197

Query: 1313 MFGNFKRLVYIDRAPFVLTHDMVYVINGGERPTQRFQHFVELCCMAFNIVRAHHDHILDL 1372
            MFGN KR    DRAPFV T DM YVINGG++P+ RF  FV+LCC A+N++R H    L+L
Sbjct: 1198 MFGNIKR----DRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLFLNL 1253

Query: 1373 FALP-SC---------------DSGGSERTVAGGRPQMSLSGVPGVTSAAVSYVRXXXXX 1416
              L  SC               D+   + T A      +      + S A          
Sbjct: 1254 LGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLIESSLGSVATKLNFFIHNL 1313

Query: 1417 XXXXXXXXXXXXRLIHSSLKSNMTQEGRLVSVECLGYEKRYDPEKHYVYALRIYRLGQAT 1476
                         L  +S    +   GR+  V    +EK + P K Y+Y +++ R     
Sbjct: 1314 AQMKFTGSDDRLTLSFASRTHTLKSSGRISDVFLCRHEKIFHPNKGYIYVVKVMRENTHE 1373

Query: 1477 PSVLYRSYKHFTELYQKICLHFP 1499
             + + R+++ F EL+ K+ L FP
Sbjct: 1374 ATYIQRTFEEFQELHNKLRLLFP 1396


>BC130277-1|AAI30278.1| 1444|Homo sapiens phosphoinositide-3-kinase,
            class 2, gamma polypeptide protein.
          Length = 1444

 Score =  311 bits (764), Expect = 1e-83
 Identities = 180/479 (37%), Positives = 252/479 (52%), Gaps = 34/479 (7%)

Query: 900  ECREVMWEKRQYLVQIPGALPLVLLAATNWYGDHREQLIGLLRLWEKPSPLNAMHLLLPC 959
            E +  +W  R Y      +LPLVL +A  W      ++  +LR W    PL A+ LL   
Sbjct: 671  EKKRYLWFYRFYCNNENCSLPLVLGSAPGWDERTVSEMHTILRRWTFSQPLEALGLLTSS 730

Query: 960  FPDVAVRETAAKLLNEMSDDDLCRVLPQLTQALRHETYXXXXXXXXXXXXXXXXXXXXXX 1019
            FPD  +R+ A + L+ + +D+L   LPQL QA++ E                        
Sbjct: 731  FPDQEIRKVAVQQLDNLLNDELLEYLPQLVQAVKFEWNLESPLVQLLLHRSLQSIQVAHR 790

Query: 1020 XFWLLVHSLPNIPQAPHQEFLGINLEDNASENAETDASMSASWRYTLMLRALLVICGENL 1079
             +WLL                         +NAE +A    SW Y  +L AL    G+ L
Sbjct: 791  LYWLL-------------------------KNAENEAYFK-SW-YQKLLAALQFCAGKAL 823

Query: 1080 NKTLLRQQLLVKSLCEMAVSVKCAKEXXXXXXXXXXXXXXXXXXXXQPTA-LPLALHKYV 1138
            N    ++Q L+K L ++   VK A +                      T  LPL     +
Sbjct: 824  NDEFSKEQKLIKILGDIGERVKSASDHQRQEVLKKEIGRLEEFFQDVNTCHLPLNPALCI 883

Query: 1139 HDLDVKSCTYFSSNTLPLKINFIGTD--NAVIPAMFKVGDDLRQDALVLQVIKIMDTLWL 1196
              +D  +C+YF+SN LPLKI FI  +     I  +FK GDDLRQD LVLQ+I++MD +WL
Sbjct: 884  KGIDHDACSYFTSNALPLKITFINANLMGKNISIIFKAGDDLRQDMLVLQLIQVMDNIWL 943

Query: 1197 KAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQTEWGLTGSFKDKPIAEWLAKHNPS 1256
            + GLD++M+ ++ L T   +G++++V +A TL  I    GL G  K+  I +W ++HN  
Sbjct: 944  QEGLDMQMIIYRCLSTGKDQGLVQMVPDAVTLAKIHRHSGLIGPLKENTIKKWFSQHNHL 1003

Query: 1257 ELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGN 1316
            + +Y++A  NF  SCAG+ V T++LG+CDRHNDNIML  SGH+FHIDFGKFLG AQ FG 
Sbjct: 1004 KADYEKALRNFFYSCAGWCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGG 1063

Query: 1317 FKRLVYIDRAPFVLTHDMVYVINGGERPTQRFQHFVELCCMAFNIVRAHHDHILDLFAL 1375
             KR    DRAPF+ T +M Y I  G +  Q FQ FVELCC A+NI+R H   +L+L  +
Sbjct: 1064 IKR----DRAPFIFTSEMEYFITEGGKNPQHFQDFVELCCRAYNIIRKHSQLLLNLLEM 1118


>AJ000008-1|CAA03853.1| 1448|Homo sapiens PI3-kinase protein.
          Length = 1448

 Score =  308 bits (756), Expect = 1e-82
 Identities = 179/479 (37%), Positives = 251/479 (52%), Gaps = 34/479 (7%)

Query: 900  ECREVMWEKRQYLVQIPGALPLVLLAATNWYGDHREQLIGLLRLWEKPSPLNAMHLLLPC 959
            E +  +W  R Y      +LPLVL +A  W      ++  +LR W    PL A+ LL   
Sbjct: 672  EKKRYLWFYRFYCNNENCSLPLVLGSAPGWDERTVSEMHTILRRWTFSQPLEALGLLTSS 731

Query: 960  FPDVAVRETAAKLLNEMSDDDLCRVLPQLTQALRHETYXXXXXXXXXXXXXXXXXXXXXX 1019
            FPD  +R+ A + L+ + +D+L   LPQL QA++ E                        
Sbjct: 732  FPDQEIRKVAVQQLDNLLNDELLEYLPQLVQAVKFEWNLESPLVQLLLHRSLQSIQVAHR 791

Query: 1020 XFWLLVHSLPNIPQAPHQEFLGINLEDNASENAETDASMSASWRYTLMLRALLVICGENL 1079
             +WLL                         +NAE +A    SW Y  +L AL    G+ L
Sbjct: 792  LYWLL-------------------------KNAENEAYFK-SW-YQKLLAALQFCAGKAL 824

Query: 1080 NKTLLRQQLLVKSLCEMAVSVKCAKEXXXXXXXXXXXXXXXXXXXXQPTA-LPLALHKYV 1138
            N    ++Q L+K L ++   VK A +                      T  LPL     +
Sbjct: 825  NDEFSKEQKLIKILGDIGERVKSASDHQRQEVLKKEIGRLEEFFQDVNTCHLPLNPALCI 884

Query: 1139 HDLDVKSCTYFSSNTLPLKINFIGTD--NAVIPAMFKVGDDLRQDALVLQVIKIMDTLWL 1196
              +D  +C+YF+SN LPLKI FI  +     I  +FK GDDLRQD LVLQ+I++MD +WL
Sbjct: 885  KGIDHDACSYFTSNALPLKITFINANLMGKNISIIFKAGDDLRQDMLVLQLIQVMDNIWL 944

Query: 1197 KAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQTEWGLTGSFKDKPIAEWLAKHNPS 1256
            + GLD++M+ ++ L T   + ++++V +A TL  I    GL G  K+  I +W ++HN  
Sbjct: 945  QEGLDMQMIIYRCLSTGKDQRLVQMVPDAVTLAKIHRHSGLIGPLKENTIKKWFSQHNHL 1004

Query: 1257 ELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGN 1316
            + +Y++A  NF  SCAG+ V T++LG+CDRHNDNIML  SGH+FHIDFGKFLG AQ FG 
Sbjct: 1005 KADYEKALRNFFYSCAGWCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGG 1064

Query: 1317 FKRLVYIDRAPFVLTHDMVYVINGGERPTQRFQHFVELCCMAFNIVRAHHDHILDLFAL 1375
             KR    DRAPF+ T +M Y I  G +  Q FQ FVELCC A+NI+R H   +L+L  +
Sbjct: 1065 IKR----DRAPFIFTSEMEYFITEGGKNPQHFQDFVELCCRAYNIIRKHSQLLLNLLEM 1119


>S67334-1|AAB29081.1| 1070|Homo sapiens phosphatidylinositol 3-kinase
            p110 beta isoform protein.
          Length = 1070

 Score =  234 bits (573), Expect = 2e-60
 Identities = 190/653 (29%), Positives = 299/653 (45%), Gaps = 50/653 (7%)

Query: 739  DLPVNTLPRESRLVLTLHGRTQRTIDSQHPNENSPPSSQEAEDSGDVLYEQVELGWAALQ 798
            D+ +  LPR +RL   ++    +    +     +P   Q    +G V Y    + W    
Sbjct: 388  DINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYP---VAWVNTM 444

Query: 799  LFDFDGMLSSGNYVLPLWPTSCDRRXXXX----XXXXXXXXXXXXVVNIEIPLYAHTGVK 854
            +FDF G L +G+ +L  W +  D                       ++++ P        
Sbjct: 445  VFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQTNPYTENATALHVKFPENKKQPYY 504

Query: 855  WTSGEE--DKQKNISLKDLPSFDSLDGHTQSQLL-HLIEQGAYQRMPTECREVMWEKRQY 911
            +   ++  +K   I+  D  +  S  G     +L  ++++    ++     +++W  RQ 
Sbjct: 505  YPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKEILDRDPLSQLCENEMDLIWTLRQD 564

Query: 912  LVQI-PGALPLVLLAATNWYGDHREQLIGLLRLWEKPSPLNAMHLLLPCFPDVAVRETAA 970
              +I P +LP +LL+      +   QL  LL++W K  P  A+ LL   +PD  VRE A 
Sbjct: 565  CREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAV 624

Query: 971  KLLNEMSDDDLCRVLPQLTQALRHETYXXXXXXXXXXXXXXXXXXXXXXXFWLLVHSLPN 1030
              L +MSD++L + L QL Q L++E +                       FW L  S  +
Sbjct: 625  GCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALGNRRIGQFLFWHL-RSEVH 683

Query: 1031 IPQAPHQEFLGINLEDNASENAETDASMSASWRYTLMLRALLVICGENLNKTLLRQQLLV 1090
            IP    Q   G+ LE          A    S  +  +L   +    E LNK      L+ 
Sbjct: 684  IPAVSVQ--FGVILE----------AYCRGSVGHMKVLSKQV----EALNKLKTLNSLIK 727

Query: 1091 KSLCEMAVSVKCAKEXXXXXXXXXXXXXXXXXXXXQPTALPLALHKYVHDLDVKSCTYFS 1150
             +    AV +  AK                     Q    P  +   + +L V+ C Y  
Sbjct: 728  LN----AVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVI---LSELYVEKCKYMD 780

Query: 1151 SNTLPLKINF----IGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLRMVT 1206
            S   PL + +     G D+  +  +FK GDDLRQD L LQ++++MD LW +AGLDLRM+ 
Sbjct: 781  SKMKPLWLVYNNKVFGEDS--VGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLP 838

Query: 1207 FQALPTSNSKGMIEIVTEAETLRAIQ---TEWGLTGSFKDKPIAEWLAKHNPSELEYQRA 1263
            +  L T +  G+IE+V+ +ET+  IQ   +      +F    +  WL ++N  + +  RA
Sbjct: 839  YGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGD-DLDRA 897

Query: 1264 RDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRLVYI 1323
             + FT SCAGY VA+Y+LGI DRH+DNIM+K +G LFHIDFG  LG+ +     KR    
Sbjct: 898  IEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKR---- 953

Query: 1324 DRAPFVLTHDMVYVINGGER-PTQRFQHFVELCCMAFNIVRAHHDHILDLFAL 1375
            +R PF+LT+D ++VI  G+   T++F  F + C  A+ I+R H +  + LFAL
Sbjct: 954  ERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFAL 1006


>BC114432-1|AAI14433.1| 1070|Homo sapiens phosphoinositide-3-kinase,
            catalytic, beta polypeptide protein.
          Length = 1070

 Score =  234 bits (573), Expect = 2e-60
 Identities = 190/653 (29%), Positives = 299/653 (45%), Gaps = 50/653 (7%)

Query: 739  DLPVNTLPRESRLVLTLHGRTQRTIDSQHPNENSPPSSQEAEDSGDVLYEQVELGWAALQ 798
            D+ +  LPR +RL   ++    +    +     +P   Q    +G V Y    + W    
Sbjct: 388  DINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYP---VAWVNTM 444

Query: 799  LFDFDGMLSSGNYVLPLWPTSCDRRXXXX----XXXXXXXXXXXXVVNIEIPLYAHTGVK 854
            +FDF G L +G+ +L  W +  D                       ++++ P        
Sbjct: 445  VFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQTNPYTENATALHVKFPENKKQPYY 504

Query: 855  WTSGEE--DKQKNISLKDLPSFDSLDGHTQSQLL-HLIEQGAYQRMPTECREVMWEKRQY 911
            +   ++  +K   I+  D  +  S  G     +L  ++++    ++     +++W  RQ 
Sbjct: 505  YPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKEILDRDPLSQLCENEMDLIWTLRQD 564

Query: 912  LVQI-PGALPLVLLAATNWYGDHREQLIGLLRLWEKPSPLNAMHLLLPCFPDVAVRETAA 970
              +I P +LP +LL+      +   QL  LL++W K  P  A+ LL   +PD  VRE A 
Sbjct: 565  CREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAV 624

Query: 971  KLLNEMSDDDLCRVLPQLTQALRHETYXXXXXXXXXXXXXXXXXXXXXXXFWLLVHSLPN 1030
              L +MSD++L + L QL Q L++E +                       FW L  S  +
Sbjct: 625  GCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALGNRRIGQFLFWHL-RSEVH 683

Query: 1031 IPQAPHQEFLGINLEDNASENAETDASMSASWRYTLMLRALLVICGENLNKTLLRQQLLV 1090
            IP    Q   G+ LE          A    S  +  +L   +    E LNK      L+ 
Sbjct: 684  IPAVSVQ--FGVILE----------AYCRGSVGHMKVLSKQV----EALNKLKTLNSLIK 727

Query: 1091 KSLCEMAVSVKCAKEXXXXXXXXXXXXXXXXXXXXQPTALPLALHKYVHDLDVKSCTYFS 1150
             +    AV +  AK                     Q    P  +   + +L V+ C Y  
Sbjct: 728  LN----AVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVI---LSELYVEKCKYMD 780

Query: 1151 SNTLPLKINF----IGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLRMVT 1206
            S   PL + +     G D+  +  +FK GDDLRQD L LQ++++MD LW +AGLDLRM+ 
Sbjct: 781  SKMKPLWLVYNNKVFGEDS--VGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLP 838

Query: 1207 FQALPTSNSKGMIEIVTEAETLRAIQ---TEWGLTGSFKDKPIAEWLAKHNPSELEYQRA 1263
            +  L T +  G+IE+V+ +ET+  IQ   +      +F    +  WL ++N  + +  RA
Sbjct: 839  YGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGD-DLDRA 897

Query: 1264 RDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRLVYI 1323
             + FT SCAGY VA+Y+LGI DRH+DNIM+K +G LFHIDFG  LG+ +     KR    
Sbjct: 898  IEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKR---- 953

Query: 1324 DRAPFVLTHDMVYVINGGER-PTQRFQHFVELCCMAFNIVRAHHDHILDLFAL 1375
            +R PF+LT+D ++VI  G+   T++F  F + C  A+ I+R H +  + LFAL
Sbjct: 954  ERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFAL 1006


>AJ297549-1|CAC21449.1| 1070|Homo sapiens phosphatidylinositol
            3-kinase catalytic subunit p110beta protein.
          Length = 1070

 Score =  234 bits (573), Expect = 2e-60
 Identities = 190/653 (29%), Positives = 299/653 (45%), Gaps = 50/653 (7%)

Query: 739  DLPVNTLPRESRLVLTLHGRTQRTIDSQHPNENSPPSSQEAEDSGDVLYEQVELGWAALQ 798
            D+ +  LPR +RL   ++    +    +     +P   Q    +G V Y    + W    
Sbjct: 388  DINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYP---VAWVNTM 444

Query: 799  LFDFDGMLSSGNYVLPLWPTSCDRRXXXX----XXXXXXXXXXXXVVNIEIPLYAHTGVK 854
            +FDF G L +G+ +L  W +  D                       ++++ P        
Sbjct: 445  VFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQTNPYTENATALHVKFPENKKQPYY 504

Query: 855  WTSGEE--DKQKNISLKDLPSFDSLDGHTQSQLL-HLIEQGAYQRMPTECREVMWEKRQY 911
            +   ++  +K   I+  D  +  S  G     +L  ++++    ++     +++W  RQ 
Sbjct: 505  YPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKEILDRDPLSQLCENEMDLIWTLRQD 564

Query: 912  LVQI-PGALPLVLLAATNWYGDHREQLIGLLRLWEKPSPLNAMHLLLPCFPDVAVRETAA 970
              +I P +LP +LL+      +   QL  LL++W K  P  A+ LL   +PD  VRE A 
Sbjct: 565  CREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAV 624

Query: 971  KLLNEMSDDDLCRVLPQLTQALRHETYXXXXXXXXXXXXXXXXXXXXXXXFWLLVHSLPN 1030
              L +MSD++L + L QL Q L++E +                       FW L  S  +
Sbjct: 625  GCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALGNRRIGQFLFWHL-RSEVH 683

Query: 1031 IPQAPHQEFLGINLEDNASENAETDASMSASWRYTLMLRALLVICGENLNKTLLRQQLLV 1090
            IP    Q   G+ LE          A    S  +  +L   +    E LNK      L+ 
Sbjct: 684  IPAVSVQ--FGVILE----------AYCRGSVGHMKVLSKQV----EALNKLKTLNSLIK 727

Query: 1091 KSLCEMAVSVKCAKEXXXXXXXXXXXXXXXXXXXXQPTALPLALHKYVHDLDVKSCTYFS 1150
             +    AV +  AK                     Q    P  +   + +L V+ C Y  
Sbjct: 728  LN----AVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVI---LSELYVEKCKYMD 780

Query: 1151 SNTLPLKINF----IGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLRMVT 1206
            S   PL + +     G D+  +  +FK GDDLRQD L LQ++++MD LW +AGLDLRM+ 
Sbjct: 781  SKMKPLWLVYNNKVFGEDS--VGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLP 838

Query: 1207 FQALPTSNSKGMIEIVTEAETLRAIQ---TEWGLTGSFKDKPIAEWLAKHNPSELEYQRA 1263
            +  L T +  G+IE+V+ +ET+  IQ   +      +F    +  WL ++N  + +  RA
Sbjct: 839  YGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGD-DLDRA 897

Query: 1264 RDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRLVYI 1323
             + FT SCAGY VA+Y+LGI DRH+DNIM+K +G LFHIDFG  LG+ +     KR    
Sbjct: 898  IEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKR---- 953

Query: 1324 DRAPFVLTHDMVYVINGGER-PTQRFQHFVELCCMAFNIVRAHHDHILDLFAL 1375
            +R PF+LT+D ++VI  G+   T++F  F + C  A+ I+R H +  + LFAL
Sbjct: 954  ERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFAL 1006


>BC035683-1|AAH35683.1| 1102|Homo sapiens PIK3CG protein protein.
          Length = 1102

 Score =  215 bits (524), Expect = 1e-54
 Identities = 182/678 (26%), Positives = 301/678 (44%), Gaps = 75/678 (11%)

Query: 725  FYPRIIFDTWLNLEDLPVNTLPRESRLVLTLHGRTQRTIDSQHPNENSPPSSQEAEDSGD 784
            F   ++++ WL    + +  LP+ + L L ++      + S+   E+  PSS E++    
Sbjct: 404  FTEEVLWNVWLEFS-IKIKDLPKGALLNLQIYCGKAPALSSKASAES--PSS-ESKGKVQ 459

Query: 785  VLYEQVELGWAALQLFDFDGMLSSGNYVLPLWPTSCDRRXXXXXXXXXXXXXX------X 838
            +LY      +  L L D   +L  G YVL +W  S                         
Sbjct: 460  LLY------YVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENS 513

Query: 839  XVVNIEIPLYAHT-GVKWTSGEEDKQKNISLKDLPSFDSLDGHTQSQLLHLIEQGAYQRM 897
              ++I +  Y H   +       D + +    ++P+        + QL  +I       +
Sbjct: 514  MSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPN------QLRKQLEAIIATDPLNPL 567

Query: 898  PTECREVMWEKRQYLVQIPGALPLVLLAATNWYGDH----REQLIGLLRLWEKPS-PLNA 952
              E +E++W  R   ++ P A P  L ++  W          QL+    +W++ +  +  
Sbjct: 568  TAEDKELLWHFRYESLKHPKAYPK-LFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGL 626

Query: 953  MHLLLPC-FPDVAVRETAAKLLNEMSDDDLCRVLPQLTQALRHETYXXXXXXXXXXXXXX 1011
               LL C F D  VR  A + L  + DDD+   L QL QA++ E Y              
Sbjct: 627  TMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGL 686

Query: 1012 XXXXXXXXXFWLLVHSLPNIPQAPHQEFLGINLEDNASENAETDASMSASWRYTLMLRAL 1071
                     FW L      I Q+ H +                        R+ ++L A 
Sbjct: 687  RNKRIGHFLFWFL---RSEIAQSRHYQ-----------------------QRFAVILEAY 720

Query: 1072 LVICGENLNKTLLRQQLLVKSLCEMAVSVKCAKEXXXXXXXXXXXXXXXXXXXXQPTALP 1131
            L  CG  +     +Q  +++ L ++ + +K                        Q + LP
Sbjct: 721  LRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLP 780

Query: 1132 LALHKYVHD-------LDVKSCTYFSSNTLPLKINFIGTD-----NAVIPAMFKVGDDLR 1179
             +  +  +D       L ++ C   +S   PL + F   D     N  I  +FK GDDLR
Sbjct: 781  ESF-RVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLR 839

Query: 1180 QDALVLQVIKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQTEW-GLT 1238
            QD L+LQ+++IM+++W    LDL ++ +  + T +  GMIEIV +A T+  IQ    G T
Sbjct: 840  QDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNT 899

Query: 1239 GSFKDKPIAEWLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGH 1298
            G+FKD+ +  WL + +P+E ++Q A + F  SCAGY VAT++LGI DRHNDNIM+  +G+
Sbjct: 900  GAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGN 959

Query: 1299 LFHIDFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVI-NGGERPTQRFQHFVELCCM 1357
            LFHIDFG  LG+ + F    +    +R PFVLT D ++V+   G++ +  FQ F ++C  
Sbjct: 960  LFHIDFGHILGNYKSFLGINK----ERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVK 1015

Query: 1358 AFNIVRAHHDHILDLFAL 1375
            A+  +R H + ++ LF++
Sbjct: 1016 AYLALRHHTNLLIILFSM 1033



 Score = 34.3 bits (75), Expect = 3.4
 Identities = 23/106 (21%), Positives = 47/106 (44%), Gaps = 5/106 (4%)

Query: 406 NTSIKILVHHAHSDEPITFT-SDVESKVEHVILTVVCSLDE--DIREDMS--GYMLRVRG 460
           N  I I++H + + + I  +  D    +     T +       DI E  S   ++LRV G
Sbjct: 217 NNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCG 276

Query: 461 AKEYLTPGSSLSEYDYIRECVRLEKDVTLCLHEGRDSTLARTERDD 506
             EYL   + +  + ++R C++  +++ + L    D  L    +++
Sbjct: 277 RDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEE 322


>AC005018-1|AAQ96873.1| 1102|Homo sapiens unknown protein.
          Length = 1102

 Score =  215 bits (524), Expect = 1e-54
 Identities = 182/678 (26%), Positives = 301/678 (44%), Gaps = 75/678 (11%)

Query: 725  FYPRIIFDTWLNLEDLPVNTLPRESRLVLTLHGRTQRTIDSQHPNENSPPSSQEAEDSGD 784
            F   ++++ WL    + +  LP+ + L L ++      + S+   E+  PSS E++    
Sbjct: 404  FTEEVLWNVWLEFS-IKIKDLPKGALLNLQIYCGKAPALSSKASAES--PSS-ESKGKVQ 459

Query: 785  VLYEQVELGWAALQLFDFDGMLSSGNYVLPLWPTSCDRRXXXXXXXXXXXXXX------X 838
            +LY      +  L L D   +L  G YVL +W  S                         
Sbjct: 460  LLY------YVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENS 513

Query: 839  XVVNIEIPLYAHT-GVKWTSGEEDKQKNISLKDLPSFDSLDGHTQSQLLHLIEQGAYQRM 897
              ++I +  Y H   +       D + +    ++P+        + QL  +I       +
Sbjct: 514  MSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPN------QLRKQLEAIIATDPLNPL 567

Query: 898  PTECREVMWEKRQYLVQIPGALPLVLLAATNWYGDH----REQLIGLLRLWEKPS-PLNA 952
              E +E++W  R   ++ P A P  L ++  W          QL+    +W++ +  +  
Sbjct: 568  TAEDKELLWHFRYESLKHPKAYPK-LFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGL 626

Query: 953  MHLLLPC-FPDVAVRETAAKLLNEMSDDDLCRVLPQLTQALRHETYXXXXXXXXXXXXXX 1011
               LL C F D  VR  A + L  + DDD+   L QL QA++ E Y              
Sbjct: 627  TMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGL 686

Query: 1012 XXXXXXXXXFWLLVHSLPNIPQAPHQEFLGINLEDNASENAETDASMSASWRYTLMLRAL 1071
                     FW L      I Q+ H +                        R+ ++L A 
Sbjct: 687  RNKRIGHFLFWFL---RSEIAQSRHYQ-----------------------QRFAVILEAY 720

Query: 1072 LVICGENLNKTLLRQQLLVKSLCEMAVSVKCAKEXXXXXXXXXXXXXXXXXXXXQPTALP 1131
            L  CG  +     +Q  +++ L ++ + +K                        Q + LP
Sbjct: 721  LRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLP 780

Query: 1132 LALHKYVHD-------LDVKSCTYFSSNTLPLKINFIGTD-----NAVIPAMFKVGDDLR 1179
             +  +  +D       L ++ C   +S   PL + F   D     N  I  +FK GDDLR
Sbjct: 781  ESF-RVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLR 839

Query: 1180 QDALVLQVIKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQTEW-GLT 1238
            QD L+LQ+++IM+++W    LDL ++ +  + T +  GMIEIV +A T+  IQ    G T
Sbjct: 840  QDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNT 899

Query: 1239 GSFKDKPIAEWLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGH 1298
            G+FKD+ +  WL + +P+E ++Q A + F  SCAGY VAT++LGI DRHNDNIM+  +G+
Sbjct: 900  GAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGN 959

Query: 1299 LFHIDFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVI-NGGERPTQRFQHFVELCCM 1357
            LFHIDFG  LG+ + F    +    +R PFVLT D ++V+   G++ +  FQ F ++C  
Sbjct: 960  LFHIDFGHILGNYKSFLGINK----ERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVK 1015

Query: 1358 AFNIVRAHHDHILDLFAL 1375
            A+  +R H + ++ LF++
Sbjct: 1016 AYLALRHHTNLLIILFSM 1033



 Score = 34.3 bits (75), Expect = 3.4
 Identities = 23/106 (21%), Positives = 47/106 (44%), Gaps = 5/106 (4%)

Query: 406 NTSIKILVHHAHSDEPITFT-SDVESKVEHVILTVVCSLDE--DIREDMS--GYMLRVRG 460
           N  I I++H + + + I  +  D    +     T +       DI E  S   ++LRV G
Sbjct: 217 NNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCG 276

Query: 461 AKEYLTPGSSLSEYDYIRECVRLEKDVTLCLHEGRDSTLARTERDD 506
             EYL   + +  + ++R C++  +++ + L    D  L    +++
Sbjct: 277 RDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEE 322


>X83368-1|CAA58284.1| 1101|Homo sapiens idem protein.
          Length = 1101

 Score =  214 bits (522), Expect = 2e-54
 Identities = 182/678 (26%), Positives = 301/678 (44%), Gaps = 75/678 (11%)

Query: 725  FYPRIIFDTWLNLEDLPVNTLPRESRLVLTLHGRTQRTIDSQHPNENSPPSSQEAEDSGD 784
            F   ++++ WL    + +  LP+ + L L ++      + S+   E+  PSS E++    
Sbjct: 403  FTEEVLWNVWLEFS-IKIKDLPKGALLNLQIYCGKAPALSSKASAES--PSS-ESKGKVR 458

Query: 785  VLYEQVELGWAALQLFDFDGMLSSGNYVLPLWPTSCDRRXXXXXXXXXXXXXX------X 838
            +LY      +  L L D   +L  G YVL +W  S                         
Sbjct: 459  LLY------YVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENS 512

Query: 839  XVVNIEIPLYAHT-GVKWTSGEEDKQKNISLKDLPSFDSLDGHTQSQLLHLIEQGAYQRM 897
              ++I +  Y H   +       D + +    ++P+        + QL  +I       +
Sbjct: 513  MSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPN------QLRKQLEAIIATDPLNPL 566

Query: 898  PTECREVMWEKRQYLVQIPGALPLVLLAATNWYGDH----REQLIGLLRLWEKPS-PLNA 952
              E +E++W  R   ++ P A P  L ++  W          QL+    +W++ +  +  
Sbjct: 567  TAEDKELLWHFRYESLKHPKAYPK-LFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGL 625

Query: 953  MHLLLPC-FPDVAVRETAAKLLNEMSDDDLCRVLPQLTQALRHETYXXXXXXXXXXXXXX 1011
               LL C F D  VR  A + L  + DDD+   L QL QA++ E Y              
Sbjct: 626  TMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGL 685

Query: 1012 XXXXXXXXXFWLLVHSLPNIPQAPHQEFLGINLEDNASENAETDASMSASWRYTLMLRAL 1071
                     FW L      I Q+ H +                        R+ ++L A 
Sbjct: 686  RNKRIGHFLFWFL---RSEIAQSRHYQ-----------------------QRFAVILEAY 719

Query: 1072 LVICGENLNKTLLRQQLLVKSLCEMAVSVKCAKEXXXXXXXXXXXXXXXXXXXXQPTALP 1131
            L  CG  +     +Q  +++ L ++ + +K                        Q + LP
Sbjct: 720  LRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLP 779

Query: 1132 LALHKYVHD-------LDVKSCTYFSSNTLPLKINFIGTD-----NAVIPAMFKVGDDLR 1179
             +  +  +D       L ++ C   +S   PL + F   D     N  I  +FK GDDLR
Sbjct: 780  ESF-RVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLR 838

Query: 1180 QDALVLQVIKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQTEW-GLT 1238
            QD L+LQ+++IM+++W    LDL ++ +  + T +  GMIEIV +A T+  IQ    G T
Sbjct: 839  QDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNT 898

Query: 1239 GSFKDKPIAEWLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGH 1298
            G+FKD+ +  WL + +P+E ++Q A + F  SCAGY VAT++LGI DRHNDNIM+  +G+
Sbjct: 899  GAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGN 958

Query: 1299 LFHIDFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVI-NGGERPTQRFQHFVELCCM 1357
            LFHIDFG  LG+ + F    +    +R PFVLT D ++V+   G++ +  FQ F ++C  
Sbjct: 959  LFHIDFGHILGNYKSFLGINK----ERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVK 1014

Query: 1358 AFNIVRAHHDHILDLFAL 1375
            A+  +R H + ++ LF++
Sbjct: 1015 AYLALRHHTNLLIILFSM 1032



 Score = 34.3 bits (75), Expect = 3.4
 Identities = 23/106 (21%), Positives = 47/106 (44%), Gaps = 5/106 (4%)

Query: 406 NTSIKILVHHAHSDEPITFT-SDVESKVEHVILTVVCSLDE--DIREDMS--GYMLRVRG 460
           N  I I++H + + + I  +  D    +     T +       DI E  S   ++LRV G
Sbjct: 216 NNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCG 275

Query: 461 AKEYLTPGSSLSEYDYIRECVRLEKDVTLCLHEGRDSTLARTERDD 506
             EYL   + +  + ++R C++  +++ + L    D  L    +++
Sbjct: 276 RDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEE 321


>AF327656-1|AAG61115.1| 1102|Homo sapiens phosphoinositide-3-kinase
            gamma catalytic subunit protein.
          Length = 1102

 Score =  214 bits (522), Expect = 2e-54
 Identities = 182/678 (26%), Positives = 301/678 (44%), Gaps = 75/678 (11%)

Query: 725  FYPRIIFDTWLNLEDLPVNTLPRESRLVLTLHGRTQRTIDSQHPNENSPPSSQEAEDSGD 784
            F   ++++ WL    + +  LP+ + L L ++      + S+   E+  PSS E++    
Sbjct: 404  FTEEVLWNVWLEFS-IKIKDLPKGALLNLQIYCGKAPALSSKASAES--PSS-ESKGKVR 459

Query: 785  VLYEQVELGWAALQLFDFDGMLSSGNYVLPLWPTSCDRRXXXXXXXXXXXXXX------X 838
            +LY      +  L L D   +L  G YVL +W  S                         
Sbjct: 460  LLY------YVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENS 513

Query: 839  XVVNIEIPLYAHT-GVKWTSGEEDKQKNISLKDLPSFDSLDGHTQSQLLHLIEQGAYQRM 897
              ++I +  Y H   +       D + +    ++P+        + QL  +I       +
Sbjct: 514  MSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPN------QLRKQLEAIIATDPLNPL 567

Query: 898  PTECREVMWEKRQYLVQIPGALPLVLLAATNWYGDH----REQLIGLLRLWEKPS-PLNA 952
              E +E++W  R   ++ P A P  L ++  W          QL+    +W++ +  +  
Sbjct: 568  TAEDKELLWHFRYESLKHPKAYPK-LFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGL 626

Query: 953  MHLLLPC-FPDVAVRETAAKLLNEMSDDDLCRVLPQLTQALRHETYXXXXXXXXXXXXXX 1011
               LL C F D  VR  A + L  + DDD+   L QL QA++ E Y              
Sbjct: 627  TMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGL 686

Query: 1012 XXXXXXXXXFWLLVHSLPNIPQAPHQEFLGINLEDNASENAETDASMSASWRYTLMLRAL 1071
                     FW L      I Q+ H +                        R+ ++L A 
Sbjct: 687  RNKRIGHFLFWFL---RSEIAQSRHYQ-----------------------QRFAVILEAY 720

Query: 1072 LVICGENLNKTLLRQQLLVKSLCEMAVSVKCAKEXXXXXXXXXXXXXXXXXXXXQPTALP 1131
            L  CG  +     +Q  +++ L ++ + +K                        Q + LP
Sbjct: 721  LRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLP 780

Query: 1132 LALHKYVHD-------LDVKSCTYFSSNTLPLKINFIGTD-----NAVIPAMFKVGDDLR 1179
             +  +  +D       L ++ C   +S   PL + F   D     N  I  +FK GDDLR
Sbjct: 781  ESF-RVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLR 839

Query: 1180 QDALVLQVIKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQTEW-GLT 1238
            QD L+LQ+++IM+++W    LDL ++ +  + T +  GMIEIV +A T+  IQ    G T
Sbjct: 840  QDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNT 899

Query: 1239 GSFKDKPIAEWLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGH 1298
            G+FKD+ +  WL + +P+E ++Q A + F  SCAGY VAT++LGI DRHNDNIM+  +G+
Sbjct: 900  GAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGN 959

Query: 1299 LFHIDFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVI-NGGERPTQRFQHFVELCCM 1357
            LFHIDFG  LG+ + F    +    +R PFVLT D ++V+   G++ +  FQ F ++C  
Sbjct: 960  LFHIDFGHILGNYKSFLGINK----ERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVK 1015

Query: 1358 AFNIVRAHHDHILDLFAL 1375
            A+  +R H + ++ LF++
Sbjct: 1016 AYLALRHHTNLLIILFSM 1033



 Score = 34.3 bits (75), Expect = 3.4
 Identities = 23/106 (21%), Positives = 47/106 (44%), Gaps = 5/106 (4%)

Query: 406 NTSIKILVHHAHSDEPITFT-SDVESKVEHVILTVVCSLDE--DIREDMS--GYMLRVRG 460
           N  I I++H + + + I  +  D    +     T +       DI E  S   ++LRV G
Sbjct: 217 NNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCG 276

Query: 461 AKEYLTPGSSLSEYDYIRECVRLEKDVTLCLHEGRDSTLARTERDD 506
             EYL   + +  + ++R C++  +++ + L    D  L    +++
Sbjct: 277 RDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEE 322


>U57843-1|AAB53966.1| 1068|Homo sapiens phosphatidylinositol 3-kinase
            delta catalytic subunit protein.
          Length = 1068

 Score =  196 bits (479), Expect = 4e-49
 Identities = 107/252 (42%), Positives = 149/252 (59%), Gaps = 12/252 (4%)

Query: 1131 PLALHKYVHDLDVKSCTYFSSNTLPLKINFIGTD---NAVIPAMFKVGDDLRQDALVLQV 1187
            PL     + ++ V+ CT+  S   PL I +   +      +  +FK GDDLRQD L LQ+
Sbjct: 758  PLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGTVGIIFKNGDDLRQDMLTLQM 817

Query: 1188 IKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQ---TEWGLTGSFKDK 1244
            I++MD LW + GLDLRM  +  LPT +  G+IE+V  ++T+  IQ   +    T +F   
Sbjct: 818  IQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKD 877

Query: 1245 PIAEWLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHIDF 1304
             +  WL   NP E    RA + FT SCAGY VATY+LGI DRH+DNIM++ SG LFHIDF
Sbjct: 878  ALLNWLKSKNPGEA-LDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDF 936

Query: 1305 GKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGE-RPTQRFQHFVELCCMAFNIVR 1363
            G FLG+ +      R    +R PF+LT+D+V+VI  G+   +++F+ F   C  A+ I+R
Sbjct: 937  GHFLGNFKTKFGINR----ERVPFILTYDLVHVIQQGKTNNSEKFERFRGYCERAYTILR 992

Query: 1364 AHHDHILDLFAL 1375
             H    L LFAL
Sbjct: 993  RHGLLFLHLFAL 1004



 Score = 50.8 bits (116), Expect = 4e-05
 Identities = 37/119 (31%), Positives = 61/119 (51%), Gaps = 5/119 (4%)

Query: 882 QSQLLHLIEQGAYQRMPTECREVMWEKRQYLVQ-IPGALPLVLLAATNWYGDHREQLIGL 940
           Q QL  ++E+     +    ++++W+ R  + +  P AL  +LL  T W   H +     
Sbjct: 532 QLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLV-TKW-NKHEDVAPDA 589

Query: 941 LRL--WEKPSPLNAMHLLLPCFPDVAVRETAAKLLNEMSDDDLCRVLPQLTQALRHETY 997
           L    W +   L+A+ LL   FPD  V   A K L +++DD+L + L QL Q L++E+Y
Sbjct: 590 LPAVSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESY 648



 Score = 36.3 bits (80), Expect = 0.84
 Identities = 45/181 (24%), Positives = 74/181 (40%), Gaps = 28/181 (15%)

Query: 651 FRLADAHYQAPANPAKAVPAHTISETTLFCIEAVHCLPLCWSH----DEYM---FHAQIY 703
           + L     Q P      +PA   S  +L+ +E    + L        DE M     A ++
Sbjct: 254 YPLCQFQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLF 313

Query: 704 HGTRPL-KTLRFTQASKIECGGFYPRIIFDTWLNLEDLPVNTLPRESRLVLTLHGRTQRT 762
           HG   L KT+  ++ S      +  R+ FD  +N+ DLP     R +RL   L+      
Sbjct: 314 HGNEMLCKTVSSSEVSVCSEPVWKQRLEFD--INICDLP-----RMARLCFALYA----V 362

Query: 763 IDSQHPNENSPPSSQEAEDSGDVLYEQVELGWAALQLFDFDGMLSSGNYVLPLWPTSCDR 822
           I+      ++   S++A+           + WA L LFD+   L +G   L +WP+  D 
Sbjct: 363 IEKAKKARSTKKKSKKAD---------CPIAWANLMLFDYKDQLKTGERCLYMWPSVPDE 413

Query: 823 R 823
           +
Sbjct: 414 K 414


>Y10055-1|CAA71149.2| 1044|Homo sapiens phosphoinositide 3-kinase
            protein.
          Length = 1044

 Score =  195 bits (475), Expect = 1e-48
 Identities = 107/252 (42%), Positives = 148/252 (58%), Gaps = 12/252 (4%)

Query: 1131 PLALHKYVHDLDVKSCTYFSSNTLPLKINFIGTD---NAVIPAMFKVGDDLRQDALVLQV 1187
            PL     + ++ V+ CT+  S   PL I +   +      +  +FK GDDLRQD L LQ+
Sbjct: 734  PLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQM 793

Query: 1188 IKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQ---TEWGLTGSFKDK 1244
            I++MD LW + GLDLRM  +  LPT +  G+IE+V  ++T+  IQ   +    T +F   
Sbjct: 794  IQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKD 853

Query: 1245 PIAEWLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHIDF 1304
             +  WL   NP E    RA + FT SCAGY VATY+LGI DRH+DNIM++ SG LFHIDF
Sbjct: 854  ALLNWLKSKNPGEA-LDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDF 912

Query: 1305 GKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGE-RPTQRFQHFVELCCMAFNIVR 1363
            G FLG+ +      R    +R PF+LT+D V+VI  G+   +++F+ F   C  A+ I+R
Sbjct: 913  GHFLGNFKTKFGINR----ERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILR 968

Query: 1364 AHHDHILDLFAL 1375
             H    L LFAL
Sbjct: 969  RHGLLFLHLFAL 980



 Score = 69.7 bits (163), Expect = 7e-11
 Identities = 90/354 (25%), Positives = 150/354 (42%), Gaps = 41/354 (11%)

Query: 659 QAPANPAKAVPAHTISETTLFCIEAVHCLPLCWSH----DEYM---FHAQIYHGTRPL-K 710
           Q P      +PA   S  +L+ +E    + L        DE M     A ++HG   L K
Sbjct: 297 QKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCK 356

Query: 711 TLRFTQASKIECGGFYPRIIFDTWLNLEDLPVNTLPRESRLVLTLHGRTQRTIDSQHPNE 770
           T+  ++ S      +  R+ FD  +N+ DLP     R +RL   L+      I+      
Sbjct: 357 TVSSSEVSVCSEPVWKQRLEFD--INICDLP-----RMARLCFALYA----VIEKAKKAR 405

Query: 771 NSPPSSQEAEDSGDVLYEQVELGWAALQLFDFDGMLSSGNYVLPLWPTSCDRRXX----X 826
           ++   S++A+           + WA L LFD+   L +G   L +WP+  D +       
Sbjct: 406 STKKKSKKAD---------CPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPT 456

Query: 827 XXXXXXXXXXXXXVVNIEIPLYAHTGVKWTSGEEDKQKNISLKDLPSFDSLDGHTQSQLL 886
                         + I +P  A   V + + E    K + L        +    Q QL 
Sbjct: 457 GTVRSNPNTDSAAALLICLPEVAPHPVYYPALE----KILELGRHSECVHVTEEEQLQLR 512

Query: 887 HLIEQGAYQRMPTECREVMWEKRQYLVQ-IPGALPLVLLAATNWYGDHRE--QLIGLLRL 943
            ++E+     +    ++++W+ R  + +  P AL  +LL  T W   H +  Q++ LL  
Sbjct: 513 EILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLV-TKW-NKHEDVAQMLYLLCS 570

Query: 944 WEKPSPLNAMHLLLPCFPDVAVRETAAKLLNEMSDDDLCRVLPQLTQALRHETY 997
           W +   L+A+ LL   FPD  V   A K L +++DD+L + L QL Q L++E+Y
Sbjct: 571 WPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESY 624


>U86453-1|AAC25677.1| 1044|Homo sapiens phosphatidylinositol 3-kinase
            catalytic subunit p110delta protein.
          Length = 1044

 Score =  195 bits (475), Expect = 1e-48
 Identities = 107/252 (42%), Positives = 148/252 (58%), Gaps = 12/252 (4%)

Query: 1131 PLALHKYVHDLDVKSCTYFSSNTLPLKINFIGTD---NAVIPAMFKVGDDLRQDALVLQV 1187
            PL     + ++ V+ CT+  S   PL I +   +      +  +FK GDDLRQD L LQ+
Sbjct: 734  PLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQM 793

Query: 1188 IKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQ---TEWGLTGSFKDK 1244
            I++MD LW + GLDLRM  +  LPT +  G+IE+V  ++T+  IQ   +    T +F   
Sbjct: 794  IQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKD 853

Query: 1245 PIAEWLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHIDF 1304
             +  WL   NP E    RA + FT SCAGY VATY+LGI DRH+DNIM++ SG LFHIDF
Sbjct: 854  ALLNWLKSKNPGEA-LDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDF 912

Query: 1305 GKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGE-RPTQRFQHFVELCCMAFNIVR 1363
            G FLG+ +      R    +R PF+LT+D V+VI  G+   +++F+ F   C  A+ I+R
Sbjct: 913  GHFLGNFKTKFGINR----ERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILR 968

Query: 1364 AHHDHILDLFAL 1375
             H    L LFAL
Sbjct: 969  RHGLLFLHLFAL 980



 Score = 69.7 bits (163), Expect = 7e-11
 Identities = 90/354 (25%), Positives = 150/354 (42%), Gaps = 41/354 (11%)

Query: 659 QAPANPAKAVPAHTISETTLFCIEAVHCLPLCWSH----DEYM---FHAQIYHGTRPL-K 710
           Q P      +PA   S  +L+ +E    + L        DE M     A ++HG   L K
Sbjct: 297 QKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCK 356

Query: 711 TLRFTQASKIECGGFYPRIIFDTWLNLEDLPVNTLPRESRLVLTLHGRTQRTIDSQHPNE 770
           T+  ++ S      +  R+ FD  +N+ DLP     R +RL   L+      I+      
Sbjct: 357 TVSSSEVSVCSEPVWKQRLEFD--INICDLP-----RMARLCFALYA----VIEKAKKAR 405

Query: 771 NSPPSSQEAEDSGDVLYEQVELGWAALQLFDFDGMLSSGNYVLPLWPTSCDRRXX----X 826
           ++   S++A+           + WA L LFD+   L +G   L +WP+  D +       
Sbjct: 406 STKKKSKKAD---------CPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPT 456

Query: 827 XXXXXXXXXXXXXVVNIEIPLYAHTGVKWTSGEEDKQKNISLKDLPSFDSLDGHTQSQLL 886
                         + I +P  A   V + + E    K + L        +    Q QL 
Sbjct: 457 GTVRSNPNTDSAAALLICLPEVAPHPVYYPALE----KILELGRHSECVHVTEEEQLQLR 512

Query: 887 HLIEQGAYQRMPTECREVMWEKRQYLVQ-IPGALPLVLLAATNWYGDHRE--QLIGLLRL 943
            ++E+     +    ++++W+ R  + +  P AL  +LL  T W   H +  Q++ LL  
Sbjct: 513 EILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLV-TKW-NKHEDVAQMLYLLCS 570

Query: 944 WEKPSPLNAMHLLLPCFPDVAVRETAAKLLNEMSDDDLCRVLPQLTQALRHETY 997
           W +   L+A+ LL   FPD  V   A K L +++DD+L + L QL Q L++E+Y
Sbjct: 571 WPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESY 624


>DQ263596-1|ABB83816.1| 1044|Homo sapiens phosphoinositide-3-kinase D
            protein.
          Length = 1044

 Score =  195 bits (475), Expect = 1e-48
 Identities = 107/252 (42%), Positives = 148/252 (58%), Gaps = 12/252 (4%)

Query: 1131 PLALHKYVHDLDVKSCTYFSSNTLPLKINFIGTD---NAVIPAMFKVGDDLRQDALVLQV 1187
            PL     + ++ V+ CT+  S   PL I +   +      +  +FK GDDLRQD L LQ+
Sbjct: 734  PLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQM 793

Query: 1188 IKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQ---TEWGLTGSFKDK 1244
            I++MD LW + GLDLRM  +  LPT +  G+IE+V  ++T+  IQ   +    T +F   
Sbjct: 794  IQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKD 853

Query: 1245 PIAEWLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHIDF 1304
             +  WL   NP E    RA + FT SCAGY VATY+LGI DRH+DNIM++ SG LFHIDF
Sbjct: 854  ALLNWLKSKNPGEA-LDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDF 912

Query: 1305 GKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGE-RPTQRFQHFVELCCMAFNIVR 1363
            G FLG+ +      R    +R PF+LT+D V+VI  G+   +++F+ F   C  A+ I+R
Sbjct: 913  GHFLGNFKTKFGINR----ERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILR 968

Query: 1364 AHHDHILDLFAL 1375
             H    L LFAL
Sbjct: 969  RHGLLFLHLFAL 980



 Score = 69.7 bits (163), Expect = 7e-11
 Identities = 90/354 (25%), Positives = 150/354 (42%), Gaps = 41/354 (11%)

Query: 659 QAPANPAKAVPAHTISETTLFCIEAVHCLPLCWSH----DEYM---FHAQIYHGTRPL-K 710
           Q P      +PA   S  +L+ +E    + L        DE M     A ++HG   L K
Sbjct: 297 QKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCK 356

Query: 711 TLRFTQASKIECGGFYPRIIFDTWLNLEDLPVNTLPRESRLVLTLHGRTQRTIDSQHPNE 770
           T+  ++ S      +  R+ FD  +N+ DLP     R +RL   L+      I+      
Sbjct: 357 TVSSSEVSVCSEPVWKQRLEFD--INICDLP-----RMARLCFALYA----VIEKAKKAR 405

Query: 771 NSPPSSQEAEDSGDVLYEQVELGWAALQLFDFDGMLSSGNYVLPLWPTSCDRRXX----X 826
           ++   S++A+           + WA L LFD+   L +G   L +WP+  D +       
Sbjct: 406 STKKKSKKAD---------CPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPA 456

Query: 827 XXXXXXXXXXXXXVVNIEIPLYAHTGVKWTSGEEDKQKNISLKDLPSFDSLDGHTQSQLL 886
                         + I +P  A   V + + E    K + L        +    Q QL 
Sbjct: 457 GTVRSNPNTDSAAALLICLPEVAPHPVYYPALE----KILELGRHSECVHVTEEEQLQLR 512

Query: 887 HLIEQGAYQRMPTECREVMWEKRQYLVQ-IPGALPLVLLAATNWYGDHRE--QLIGLLRL 943
            ++E+     +    ++++W+ R  + +  P AL  +LL  T W   H +  Q++ LL  
Sbjct: 513 EILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLV-TKW-NKHEDVAQMLYLLCS 570

Query: 944 WEKPSPLNAMHLLLPCFPDVAVRETAAKLLNEMSDDDLCRVLPQLTQALRHETY 997
           W +   L+A+ LL   FPD  V   A K L +++DD+L + L QL Q L++E+Y
Sbjct: 571 WPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESY 624


>DQ263595-1|ABB83815.1| 1044|Homo sapiens phosphoinositide-3-kinase C
            protein.
          Length = 1044

 Score =  195 bits (475), Expect = 1e-48
 Identities = 107/252 (42%), Positives = 148/252 (58%), Gaps = 12/252 (4%)

Query: 1131 PLALHKYVHDLDVKSCTYFSSNTLPLKINFIGTD---NAVIPAMFKVGDDLRQDALVLQV 1187
            PL     + ++ V+ CT+  S   PL I +   +      +  +FK GDDLRQD L LQ+
Sbjct: 734  PLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQM 793

Query: 1188 IKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQ---TEWGLTGSFKDK 1244
            I++MD LW + GLDLRM  +  LPT +  G+IE+V  ++T+  IQ   +    T +F   
Sbjct: 794  IQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKD 853

Query: 1245 PIAEWLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHIDF 1304
             +  WL   NP E    RA + FT SCAGY VATY+LGI DRH+DNIM++ SG LFHIDF
Sbjct: 854  ALLNWLKSKNPGEA-LDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDF 912

Query: 1305 GKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGE-RPTQRFQHFVELCCMAFNIVR 1363
            G FLG+ +      R    +R PF+LT+D V+VI  G+   +++F+ F   C  A+ I+R
Sbjct: 913  GHFLGNFKTKFGINR----ERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILR 968

Query: 1364 AHHDHILDLFAL 1375
             H    L LFAL
Sbjct: 969  RHGLLFLHLFAL 980



 Score = 69.7 bits (163), Expect = 7e-11
 Identities = 90/354 (25%), Positives = 150/354 (42%), Gaps = 41/354 (11%)

Query: 659 QAPANPAKAVPAHTISETTLFCIEAVHCLPLCWSH----DEYM---FHAQIYHGTRPL-K 710
           Q P      +PA   S  +L+ +E    + L        DE M     A ++HG   L K
Sbjct: 297 QKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCK 356

Query: 711 TLRFTQASKIECGGFYPRIIFDTWLNLEDLPVNTLPRESRLVLTLHGRTQRTIDSQHPNE 770
           T+  ++ S      +  R+ FD  +N+ DLP     R +RL   L+      I+      
Sbjct: 357 TVSSSEVSVCSEPVWKQRLEFD--INICDLP-----RMARLCFALYA----VIEKAKKAR 405

Query: 771 NSPPSSQEAEDSGDVLYEQVELGWAALQLFDFDGMLSSGNYVLPLWPTSCDRRXX----X 826
           ++   S++A+           + WA L LFD+   L +G   L +WP+  D +       
Sbjct: 406 STKKKSKKAD---------CPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPT 456

Query: 827 XXXXXXXXXXXXXVVNIEIPLYAHTGVKWTSGEEDKQKNISLKDLPSFDSLDGHTQSQLL 886
                         + I +P  A   V + + E    K + L        +    Q QL 
Sbjct: 457 GTVRSNPNTDSAAALLICLPEVAPHPVYYPALE----KILELGRHSECVHVTEEEQLQLR 512

Query: 887 HLIEQGAYQRMPTECREVMWEKRQYLVQ-IPGALPLVLLAATNWYGDHRE--QLIGLLRL 943
            ++E+     +    ++++W+ R  + +  P AL  +LL  T W   H +  Q++ LL  
Sbjct: 513 EILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLV-TKW-NKHEDVAQMLYLLCS 570

Query: 944 WEKPSPLNAMHLLLPCFPDVAVRETAAKLLNEMSDDDLCRVLPQLTQALRHETY 997
           W +   L+A+ LL   FPD  V   A K L +++DD+L + L QL Q L++E+Y
Sbjct: 571 WPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESY 624


>DQ263594-1|ABB83814.1| 1044|Homo sapiens phosphoinositide-3-kinase B
            protein.
          Length = 1044

 Score =  195 bits (475), Expect = 1e-48
 Identities = 107/252 (42%), Positives = 148/252 (58%), Gaps = 12/252 (4%)

Query: 1131 PLALHKYVHDLDVKSCTYFSSNTLPLKINFIGTD---NAVIPAMFKVGDDLRQDALVLQV 1187
            PL     + ++ V+ CT+  S   PL I +   +      +  +FK GDDLRQD L LQ+
Sbjct: 734  PLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQM 793

Query: 1188 IKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQ---TEWGLTGSFKDK 1244
            I++MD LW + GLDLRM  +  LPT +  G+IE+V  ++T+  IQ   +    T +F   
Sbjct: 794  IQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKD 853

Query: 1245 PIAEWLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHIDF 1304
             +  WL   NP E    RA + FT SCAGY VATY+LGI DRH+DNIM++ SG LFHIDF
Sbjct: 854  ALLNWLKSKNPGEA-LDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDF 912

Query: 1305 GKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGE-RPTQRFQHFVELCCMAFNIVR 1363
            G FLG+ +      R    +R PF+LT+D V+VI  G+   +++F+ F   C  A+ I+R
Sbjct: 913  GHFLGNFKTKFGINR----ERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILR 968

Query: 1364 AHHDHILDLFAL 1375
             H    L LFAL
Sbjct: 969  RHGLLFLHLFAL 980



 Score = 69.7 bits (163), Expect = 7e-11
 Identities = 90/354 (25%), Positives = 150/354 (42%), Gaps = 41/354 (11%)

Query: 659 QAPANPAKAVPAHTISETTLFCIEAVHCLPLCWSH----DEYM---FHAQIYHGTRPL-K 710
           Q P      +PA   S  +L+ +E    + L        DE M     A ++HG   L K
Sbjct: 297 QKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCK 356

Query: 711 TLRFTQASKIECGGFYPRIIFDTWLNLEDLPVNTLPRESRLVLTLHGRTQRTIDSQHPNE 770
           T+  ++ S      +  R+ FD  +N+ DLP     R +RL   L+      I+      
Sbjct: 357 TVSSSEVSVCSEPVWKQRLEFD--INICDLP-----RMARLCFALYA----VIEKAKKAR 405

Query: 771 NSPPSSQEAEDSGDVLYEQVELGWAALQLFDFDGMLSSGNYVLPLWPTSCDRRXX----X 826
           ++   S++A+           + WA L LFD+   L +G   L +WP+  D +       
Sbjct: 406 STKKKSKKAD---------CPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPT 456

Query: 827 XXXXXXXXXXXXXVVNIEIPLYAHTGVKWTSGEEDKQKNISLKDLPSFDSLDGHTQSQLL 886
                         + I +P  A   V + + E    K + L        +    Q QL 
Sbjct: 457 GTVRSNPNTDSAAALLICLPEVAPHPVYYPALE----KILELGRHSECVHVTEEEQLQLR 512

Query: 887 HLIEQGAYQRMPTECREVMWEKRQYLVQ-IPGALPLVLLAATNWYGDHRE--QLIGLLRL 943
            ++E+     +    ++++W+ R  + +  P AL  +LL  T W   H +  Q++ LL  
Sbjct: 513 EILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLV-TKW-NKHEDVAQMLYLLCS 570

Query: 944 WEKPSPLNAMHLLLPCFPDVAVRETAAKLLNEMSDDDLCRVLPQLTQALRHETY 997
           W +   L+A+ LL   FPD  V   A K L +++DD+L + L QL Q L++E+Y
Sbjct: 571 WPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESY 624


>BC132921-1|AAI32922.1| 1044|Homo sapiens phosphoinositide-3-kinase,
            catalytic, delta polypeptide protein.
          Length = 1044

 Score =  195 bits (475), Expect = 1e-48
 Identities = 107/252 (42%), Positives = 148/252 (58%), Gaps = 12/252 (4%)

Query: 1131 PLALHKYVHDLDVKSCTYFSSNTLPLKINFIGTD---NAVIPAMFKVGDDLRQDALVLQV 1187
            PL     + ++ V+ CT+  S   PL I +   +      +  +FK GDDLRQD L LQ+
Sbjct: 734  PLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQM 793

Query: 1188 IKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQ---TEWGLTGSFKDK 1244
            I++MD LW + GLDLRM  +  LPT +  G+IE+V  ++T+  IQ   +    T +F   
Sbjct: 794  IQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKD 853

Query: 1245 PIAEWLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHIDF 1304
             +  WL   NP E    RA + FT SCAGY VATY+LGI DRH+DNIM++ SG LFHIDF
Sbjct: 854  ALLNWLKSKNPGEA-LDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDF 912

Query: 1305 GKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGE-RPTQRFQHFVELCCMAFNIVR 1363
            G FLG+ +      R    +R PF+LT+D V+VI  G+   +++F+ F   C  A+ I+R
Sbjct: 913  GHFLGNFKTKFGINR----ERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILR 968

Query: 1364 AHHDHILDLFAL 1375
             H    L LFAL
Sbjct: 969  RHGLLFLHLFAL 980



 Score = 69.7 bits (163), Expect = 7e-11
 Identities = 90/354 (25%), Positives = 150/354 (42%), Gaps = 41/354 (11%)

Query: 659 QAPANPAKAVPAHTISETTLFCIEAVHCLPLCWSH----DEYM---FHAQIYHGTRPL-K 710
           Q P      +PA   S  +L+ +E    + L        DE M     A ++HG   L K
Sbjct: 297 QKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCK 356

Query: 711 TLRFTQASKIECGGFYPRIIFDTWLNLEDLPVNTLPRESRLVLTLHGRTQRTIDSQHPNE 770
           T+  ++ S      +  R+ FD  +N+ DLP     R +RL   L+      I+      
Sbjct: 357 TVSSSEVSVCSEPVWKQRLEFD--INICDLP-----RMARLCFALYA----VIEKAKKAR 405

Query: 771 NSPPSSQEAEDSGDVLYEQVELGWAALQLFDFDGMLSSGNYVLPLWPTSCDRRXX----X 826
           ++   S++A+           + WA L LFD+   L +G   L +WP+  D +       
Sbjct: 406 STKKKSKKAD---------CPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPT 456

Query: 827 XXXXXXXXXXXXXVVNIEIPLYAHTGVKWTSGEEDKQKNISLKDLPSFDSLDGHTQSQLL 886
                         + I +P  A   V + + E    K + L        +    Q QL 
Sbjct: 457 GTVRSNPNTDSAAALLICLPEVAPHPVYYPALE----KILELGRHSECVHVTEEEQLQLR 512

Query: 887 HLIEQGAYQRMPTECREVMWEKRQYLVQ-IPGALPLVLLAATNWYGDHRE--QLIGLLRL 943
            ++E+     +    ++++W+ R  + +  P AL  +LL  T W   H +  Q++ LL  
Sbjct: 513 EILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLV-TKW-NKHEDVAQMLYLLCS 570

Query: 944 WEKPSPLNAMHLLLPCFPDVAVRETAAKLLNEMSDDDLCRVLPQLTQALRHETY 997
           W +   L+A+ LL   FPD  V   A K L +++DD+L + L QL Q L++E+Y
Sbjct: 571 WPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESY 624


>BC132919-1|AAI32920.1| 1044|Homo sapiens phosphoinositide-3-kinase,
            catalytic, delta polypeptide protein.
          Length = 1044

 Score =  195 bits (475), Expect = 1e-48
 Identities = 107/252 (42%), Positives = 148/252 (58%), Gaps = 12/252 (4%)

Query: 1131 PLALHKYVHDLDVKSCTYFSSNTLPLKINFIGTD---NAVIPAMFKVGDDLRQDALVLQV 1187
            PL     + ++ V+ CT+  S   PL I +   +      +  +FK GDDLRQD L LQ+
Sbjct: 734  PLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQM 793

Query: 1188 IKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQ---TEWGLTGSFKDK 1244
            I++MD LW + GLDLRM  +  LPT +  G+IE+V  ++T+  IQ   +    T +F   
Sbjct: 794  IQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKD 853

Query: 1245 PIAEWLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHIDF 1304
             +  WL   NP E    RA + FT SCAGY VATY+LGI DRH+DNIM++ SG LFHIDF
Sbjct: 854  ALLNWLKSKNPGEA-LDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDF 912

Query: 1305 GKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGE-RPTQRFQHFVELCCMAFNIVR 1363
            G FLG+ +      R    +R PF+LT+D V+VI  G+   +++F+ F   C  A+ I+R
Sbjct: 913  GHFLGNFKTKFGINR----ERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILR 968

Query: 1364 AHHDHILDLFAL 1375
             H    L LFAL
Sbjct: 969  RHGLLFLHLFAL 980



 Score = 69.7 bits (163), Expect = 7e-11
 Identities = 90/354 (25%), Positives = 150/354 (42%), Gaps = 41/354 (11%)

Query: 659 QAPANPAKAVPAHTISETTLFCIEAVHCLPLCWSH----DEYM---FHAQIYHGTRPL-K 710
           Q P      +PA   S  +L+ +E    + L        DE M     A ++HG   L K
Sbjct: 297 QKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCK 356

Query: 711 TLRFTQASKIECGGFYPRIIFDTWLNLEDLPVNTLPRESRLVLTLHGRTQRTIDSQHPNE 770
           T+  ++ S      +  R+ FD  +N+ DLP     R +RL   L+      I+      
Sbjct: 357 TVSSSEVSVCSEPVWKQRLEFD--INICDLP-----RMARLCFALYA----VIEKAKKAR 405

Query: 771 NSPPSSQEAEDSGDVLYEQVELGWAALQLFDFDGMLSSGNYVLPLWPTSCDRRXX----X 826
           ++   S++A+           + WA L LFD+   L +G   L +WP+  D +       
Sbjct: 406 STKKKSKKAD---------CPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPT 456

Query: 827 XXXXXXXXXXXXXVVNIEIPLYAHTGVKWTSGEEDKQKNISLKDLPSFDSLDGHTQSQLL 886
                         + I +P  A   V + + E    K + L        +    Q QL 
Sbjct: 457 GTVRSNPNTDSAAALLICLPEVAPHPVYYPALE----KILELGRHSECVHVTEEEQLQLR 512

Query: 887 HLIEQGAYQRMPTECREVMWEKRQYLVQ-IPGALPLVLLAATNWYGDHRE--QLIGLLRL 943
            ++E+     +    ++++W+ R  + +  P AL  +LL  T W   H +  Q++ LL  
Sbjct: 513 EILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLV-TKW-NKHEDVAQMLYLLCS 570

Query: 944 WEKPSPLNAMHLLLPCFPDVAVRETAAKLLNEMSDDDLCRVLPQLTQALRHETY 997
           W +   L+A+ LL   FPD  V   A K L +++DD+L + L QL Q L++E+Y
Sbjct: 571 WPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESY 624


>AL691449-6|CAI15703.1| 1044|Homo sapiens phosphoinositide-3-kinase,
            catalytic, delta polypeptide protein.
          Length = 1044

 Score =  195 bits (475), Expect = 1e-48
 Identities = 107/252 (42%), Positives = 148/252 (58%), Gaps = 12/252 (4%)

Query: 1131 PLALHKYVHDLDVKSCTYFSSNTLPLKINFIGTD---NAVIPAMFKVGDDLRQDALVLQV 1187
            PL     + ++ V+ CT+  S   PL I +   +      +  +FK GDDLRQD L LQ+
Sbjct: 734  PLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQM 793

Query: 1188 IKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQ---TEWGLTGSFKDK 1244
            I++MD LW + GLDLRM  +  LPT +  G+IE+V  ++T+  IQ   +    T +F   
Sbjct: 794  IQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKD 853

Query: 1245 PIAEWLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHIDF 1304
             +  WL   NP E    RA + FT SCAGY VATY+LGI DRH+DNIM++ SG LFHIDF
Sbjct: 854  ALLNWLKSKNPGEA-LDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDF 912

Query: 1305 GKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGE-RPTQRFQHFVELCCMAFNIVR 1363
            G FLG+ +      R    +R PF+LT+D V+VI  G+   +++F+ F   C  A+ I+R
Sbjct: 913  GHFLGNFKTKFGINR----ERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILR 968

Query: 1364 AHHDHILDLFAL 1375
             H    L LFAL
Sbjct: 969  RHGLLFLHLFAL 980



 Score = 69.7 bits (163), Expect = 7e-11
 Identities = 90/354 (25%), Positives = 150/354 (42%), Gaps = 41/354 (11%)

Query: 659 QAPANPAKAVPAHTISETTLFCIEAVHCLPLCWSH----DEYM---FHAQIYHGTRPL-K 710
           Q P      +PA   S  +L+ +E    + L        DE M     A ++HG   L K
Sbjct: 297 QKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCK 356

Query: 711 TLRFTQASKIECGGFYPRIIFDTWLNLEDLPVNTLPRESRLVLTLHGRTQRTIDSQHPNE 770
           T+  ++ S      +  R+ FD  +N+ DLP     R +RL   L+      I+      
Sbjct: 357 TVSSSEVSVCSEPVWKQRLEFD--INICDLP-----RMARLCFALYA----VIEKAKKAR 405

Query: 771 NSPPSSQEAEDSGDVLYEQVELGWAALQLFDFDGMLSSGNYVLPLWPTSCDRRXX----X 826
           ++   S++A+           + WA L LFD+   L +G   L +WP+  D +       
Sbjct: 406 STKKKSKKAD---------CPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPT 456

Query: 827 XXXXXXXXXXXXXVVNIEIPLYAHTGVKWTSGEEDKQKNISLKDLPSFDSLDGHTQSQLL 886
                         + I +P  A   V + + E    K + L        +    Q QL 
Sbjct: 457 GTVRSNPNTDSAAALLICLPEVAPHPVYYPALE----KILELGRHSECVHVTEEEQLQLR 512

Query: 887 HLIEQGAYQRMPTECREVMWEKRQYLVQ-IPGALPLVLLAATNWYGDHRE--QLIGLLRL 943
            ++E+     +    ++++W+ R  + +  P AL  +LL  T W   H +  Q++ LL  
Sbjct: 513 EILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLV-TKW-NKHEDVAQMLYLLCS 570

Query: 944 WEKPSPLNAMHLLLPCFPDVAVRETAAKLLNEMSDDDLCRVLPQLTQALRHETY 997
           W +   L+A+ LL   FPD  V   A K L +++DD+L + L QL Q L++E+Y
Sbjct: 571 WPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESY 624


>AL691449-5|CAI15702.1| 1068|Homo sapiens phosphoinositide-3-kinase,
            catalytic, delta polypeptide protein.
          Length = 1068

 Score =  195 bits (475), Expect = 1e-48
 Identities = 107/252 (42%), Positives = 148/252 (58%), Gaps = 12/252 (4%)

Query: 1131 PLALHKYVHDLDVKSCTYFSSNTLPLKINFIGTD---NAVIPAMFKVGDDLRQDALVLQV 1187
            PL     + ++ V+ CT+  S   PL I +   +      +  +FK GDDLRQD L LQ+
Sbjct: 758  PLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQM 817

Query: 1188 IKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQ---TEWGLTGSFKDK 1244
            I++MD LW + GLDLRM  +  LPT +  G+IE+V  ++T+  IQ   +    T +F   
Sbjct: 818  IQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKD 877

Query: 1245 PIAEWLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHIDF 1304
             +  WL   NP E    RA + FT SCAGY VATY+LGI DRH+DNIM++ SG LFHIDF
Sbjct: 878  ALLNWLKSKNPGEA-LDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDF 936

Query: 1305 GKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGE-RPTQRFQHFVELCCMAFNIVR 1363
            G FLG+ +      R    +R PF+LT+D V+VI  G+   +++F+ F   C  A+ I+R
Sbjct: 937  GHFLGNFKTKFGINR----ERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILR 992

Query: 1364 AHHDHILDLFAL 1375
             H    L LFAL
Sbjct: 993  RHGLLFLHLFAL 1004



 Score = 57.2 bits (132), Expect = 4e-07
 Identities = 39/119 (32%), Positives = 65/119 (54%), Gaps = 5/119 (4%)

Query: 882 QSQLLHLIEQGAYQRMPTECREVMWEKRQYLVQ-IPGALPLVLLAATNWYGDHRE--QLI 938
           Q QL  ++E+     +    ++++W+ R  + +  P AL  +LL  T W   H +  Q++
Sbjct: 532 QLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLV-TKW-NKHEDVAQML 589

Query: 939 GLLRLWEKPSPLNAMHLLLPCFPDVAVRETAAKLLNEMSDDDLCRVLPQLTQALRHETY 997
            LL  W +   L+A+ LL   FPD  V   A K L +++DD+L + L QL Q L++E+Y
Sbjct: 590 YLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESY 648



 Score = 36.3 bits (80), Expect = 0.84
 Identities = 45/181 (24%), Positives = 74/181 (40%), Gaps = 28/181 (15%)

Query: 651 FRLADAHYQAPANPAKAVPAHTISETTLFCIEAVHCLPLCWSH----DEYM---FHAQIY 703
           + L     Q P      +PA   S  +L+ +E    + L        DE M     A ++
Sbjct: 254 YPLCQFQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLF 313

Query: 704 HGTRPL-KTLRFTQASKIECGGFYPRIIFDTWLNLEDLPVNTLPRESRLVLTLHGRTQRT 762
           HG   L KT+  ++ S      +  R+ FD  +N+ DLP     R +RL   L+      
Sbjct: 314 HGNEMLCKTVSSSEVSVCSEPVWKQRLEFD--INICDLP-----RMARLCFALYA----V 362

Query: 763 IDSQHPNENSPPSSQEAEDSGDVLYEQVELGWAALQLFDFDGMLSSGNYVLPLWPTSCDR 822
           I+      ++   S++A+           + WA L LFD+   L +G   L +WP+  D 
Sbjct: 363 IEKAKKARSTKKKSKKAD---------CPIAWANLMLFDYKDQLKTGERCLYMWPSVPDE 413

Query: 823 R 823
           +
Sbjct: 414 K 414


>AB208835-1|BAD92072.1|  845|Homo sapiens phosphoinositide-3-kinase,
            catalytic, delta polypeptide variant protein.
          Length = 845

 Score =  195 bits (475), Expect = 1e-48
 Identities = 107/252 (42%), Positives = 148/252 (58%), Gaps = 12/252 (4%)

Query: 1131 PLALHKYVHDLDVKSCTYFSSNTLPLKINFIGTD---NAVIPAMFKVGDDLRQDALVLQV 1187
            PL     + ++ V+ CT+  S   PL I +   +      +  +FK GDDLRQD L LQ+
Sbjct: 535  PLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQM 594

Query: 1188 IKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQ---TEWGLTGSFKDK 1244
            I++MD LW + GLDLRM  +  LPT +  G+IE+V  ++T+  IQ   +    T +F   
Sbjct: 595  IQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKD 654

Query: 1245 PIAEWLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHIDF 1304
             +  WL   NP E    RA + FT SCAGY VATY+LGI DRH+DNIM++ SG LFHIDF
Sbjct: 655  ALLNWLKSKNPGEA-LDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDF 713

Query: 1305 GKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGE-RPTQRFQHFVELCCMAFNIVR 1363
            G FLG+ +      R    +R PF+LT+D V+VI  G+   +++F+ F   C  A+ I+R
Sbjct: 714  GHFLGNFKTKFGINR----ERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILR 769

Query: 1364 AHHDHILDLFAL 1375
             H    L LFAL
Sbjct: 770  RHGLLFLHLFAL 781



 Score = 69.7 bits (163), Expect = 7e-11
 Identities = 90/354 (25%), Positives = 150/354 (42%), Gaps = 41/354 (11%)

Query: 659 QAPANPAKAVPAHTISETTLFCIEAVHCLPLCWSH----DEYM---FHAQIYHGTRPL-K 710
           Q P      +PA   S  +L+ +E    + L        DE M     A ++HG   L K
Sbjct: 98  QKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCK 157

Query: 711 TLRFTQASKIECGGFYPRIIFDTWLNLEDLPVNTLPRESRLVLTLHGRTQRTIDSQHPNE 770
           T+  ++ S      +  R+ FD  +N+ DLP     R +RL   L+      I+      
Sbjct: 158 TVSSSEVSVCSEPVWKQRLEFD--INICDLP-----RMARLCFVLYA----VIEKAKKAR 206

Query: 771 NSPPSSQEAEDSGDVLYEQVELGWAALQLFDFDGMLSSGNYVLPLWPTSCDRRXX----X 826
           ++   S++A+           + WA L LFD+   L +G   L +WP+  D +       
Sbjct: 207 STKKKSKKAD---------CPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPT 257

Query: 827 XXXXXXXXXXXXXVVNIEIPLYAHTGVKWTSGEEDKQKNISLKDLPSFDSLDGHTQSQLL 886
                         + I +P  A   V + + E    K + L        +    Q QL 
Sbjct: 258 GTVRSNPNTDSAAALLICLPEVAPHPVYYPALE----KILELGRHSECVHVTEEEQLQLW 313

Query: 887 HLIEQGAYQRMPTECREVMWEKRQYLVQ-IPGALPLVLLAATNWYGDHRE--QLIGLLRL 943
            ++E+     +    ++++W+ R  + +  P AL  +LL  T W   H +  Q++ LL  
Sbjct: 314 EILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLV-TKW-NKHEDVAQMLYLLCS 371

Query: 944 WEKPSPLNAMHLLLPCFPDVAVRETAAKLLNEMSDDDLCRVLPQLTQALRHETY 997
           W +   L+A+ LL   FPD  V   A K L +++DD+L + L QL Q L++E+Y
Sbjct: 372 WPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESY 425


>Z29090-1|CAA82333.1| 1068|Homo sapiens phosphatidylinositol 3-kinase
            protein.
          Length = 1068

 Score =  185 bits (450), Expect = 1e-45
 Identities = 105/256 (41%), Positives = 149/256 (58%), Gaps = 16/256 (6%)

Query: 1131 PLALHKYVHDLDVKSCTYFSSNTLPLKINFIGTD--NAVI----PAMFKVGDDLRQDALV 1184
            PL     + +L +K C   SS   PL +N+   D  + ++      +FK GDDLRQD L 
Sbjct: 754  PLNPAHQLGNLRLKECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLT 813

Query: 1185 LQVIKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQTEWGLTGS--FK 1242
            LQ+I+IM+ +W   GLDLRM+ +  L   +  G+IE+V  + T+  IQ + GL G+  F 
Sbjct: 814  LQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFN 873

Query: 1243 DKPIAEWLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHI 1302
               + +WL   N  E+ Y  A D FT SCAGY VAT++LGI DRHN NIM+K  G LFHI
Sbjct: 874  SHTLHQWLKDKNKGEI-YDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHI 932

Query: 1303 DFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGER---PTQRFQHFVELCCMAF 1359
            DFG FL   +    +KR    +R PFVLT D + VI+ G +    T+ F+ F E+C  A+
Sbjct: 933  DFGHFLDHKKKKFGYKR----ERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAY 988

Query: 1360 NIVRAHHDHILDLFAL 1375
              +R H +  ++LF++
Sbjct: 989  LAIRQHANLFINLFSM 1004



 Score = 62.9 bits (146), Expect = 8e-09
 Identities = 80/321 (24%), Positives = 127/321 (39%), Gaps = 45/321 (14%)

Query: 694 DEYMFHAQIYHGTRPLKTLRFTQASKIECGGFYPRIIFDTWLNLEDLPVNTLPRESRLVL 753
           D+      IYHG  PL     TQ  ++ C    PR  ++ WLN  D+ +  LPR +RL L
Sbjct: 352 DKIYVRTGIYHGGEPLCDNVNTQ--RVPCSN--PR--WNEWLNY-DIYIPDLPRAARLCL 404

Query: 754 TLHGRTQRTIDSQHPNENSPPSSQEAEDSGDVLYEQVELGWAALQLFDFDGMLSSGNYVL 813
           ++                S    + A++      E   L W  + LFD+   L SG   L
Sbjct: 405 SIC---------------SVKGRKGAKE------EHCPLAWGNINLFDYTDTLVSGKMAL 443

Query: 814 PLW--PTSCDRRXXXXXXXXXXXXXXXXVVNIEIPLYAHT-----------GVKWTSGEE 860
            LW  P   +                   + +E   ++                W+   E
Sbjct: 444 NLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVSRE 503

Query: 861 D--KQKNISLKDLPSFDS-LDGHTQSQLLHLIEQGAYQRMPTECREVMWEKRQYLVQIPG 917
                 +  L +  + D+ L  + + QL  +  +     +  + ++ +W  R Y V IP 
Sbjct: 504 AGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPE 563

Query: 918 ALPLVLLAATNWYGDHREQLIGLLRLWEKPSPLNAMHLLLPCFPDVAVRETAAKLLNE-M 976
            LP +LL+      D   Q+  L++ W    P  AM LL   +PD  VR  A + L + +
Sbjct: 564 ILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYL 623

Query: 977 SDDDLCRVLPQLTQALRHETY 997
           +DD L + L QL Q L++E Y
Sbjct: 624 TDDKLSQYLIQLVQVLKYEQY 644



 Score = 33.9 bits (74), Expect = 4.5
 Identities = 23/80 (28%), Positives = 32/80 (40%)

Query: 404 PPNTSIKILVHHAHSDEPITFTSDVESKVEHVILTVVCSLDEDIREDMSGYMLRVRGAKE 463
           P N   K  +   H   P    ++   K    +L     L   + E    Y+L+V G  E
Sbjct: 200 PNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDE 259

Query: 464 YLTPGSSLSEYDYIRECVRL 483
           Y      LS+Y YIR C+ L
Sbjct: 260 YFLEKYPLSQYKYIRSCIML 279


>U79143-1|AAB39753.1| 1068|Homo sapiens phosphoinositide
            3'-hydroxykinase p110-alpha subunit protein.
          Length = 1068

 Score =  183 bits (446), Expect = 4e-45
 Identities = 104/256 (40%), Positives = 149/256 (58%), Gaps = 16/256 (6%)

Query: 1131 PLALHKYVHDLDVKSCTYFSSNTLPLKINFIGTD--NAVI----PAMFKVGDDLRQDALV 1184
            PL     + +L ++ C   SS   PL +N+   D  + ++      +FK GDDLRQD L 
Sbjct: 754  PLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLT 813

Query: 1185 LQVIKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQTEWGLTGS--FK 1242
            LQ+I+IM+ +W   GLDLRM+ +  L   +  G+IE+V  + T+  IQ + GL G+  F 
Sbjct: 814  LQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFN 873

Query: 1243 DKPIAEWLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHI 1302
               + +WL   N  E+ Y  A D FT SCAGY VAT++LGI DRHN NIM+K  G LFHI
Sbjct: 874  SHTLHQWLKDKNKGEI-YDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHI 932

Query: 1303 DFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGER---PTQRFQHFVELCCMAF 1359
            DFG FL   +    +KR    +R PFVLT D + VI+ G +    T+ F+ F E+C  A+
Sbjct: 933  DFGHFLDHKKKKFGYKR----ERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAY 988

Query: 1360 NIVRAHHDHILDLFAL 1375
              +R H +  ++LF++
Sbjct: 989  LAIRQHANLFINLFSM 1004



 Score = 62.9 bits (146), Expect = 8e-09
 Identities = 80/321 (24%), Positives = 127/321 (39%), Gaps = 45/321 (14%)

Query: 694 DEYMFHAQIYHGTRPLKTLRFTQASKIECGGFYPRIIFDTWLNLEDLPVNTLPRESRLVL 753
           D+      IYHG  PL     TQ  ++ C    PR  ++ WLN  D+ +  LPR +RL L
Sbjct: 352 DKIYVRTGIYHGGEPLCDNVNTQ--RVPCSN--PR--WNEWLNY-DIYIPDLPRAARLCL 404

Query: 754 TLHGRTQRTIDSQHPNENSPPSSQEAEDSGDVLYEQVELGWAALQLFDFDGMLSSGNYVL 813
           ++                S    + A++      E   L W  + LFD+   L SG   L
Sbjct: 405 SIC---------------SVKGRKGAKE------EHCPLAWGNINLFDYTDTLVSGKMAL 443

Query: 814 PLW--PTSCDRRXXXXXXXXXXXXXXXXVVNIEIPLYAHT-----------GVKWTSGEE 860
            LW  P   +                   + +E   ++                W+   E
Sbjct: 444 NLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVSRE 503

Query: 861 D--KQKNISLKDLPSFDS-LDGHTQSQLLHLIEQGAYQRMPTECREVMWEKRQYLVQIPG 917
                 +  L +  + D+ L  + + QL  +  +     +  + ++ +W  R Y V IP 
Sbjct: 504 AGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPE 563

Query: 918 ALPLVLLAATNWYGDHREQLIGLLRLWEKPSPLNAMHLLLPCFPDVAVRETAAKLLNE-M 976
            LP +LL+      D   Q+  L++ W    P  AM LL   +PD  VR  A + L + +
Sbjct: 564 ILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYL 623

Query: 977 SDDDLCRVLPQLTQALRHETY 997
           +DD L + L QL Q L++E Y
Sbjct: 624 TDDKLSQYLIQLVQVLKYEQY 644



 Score = 34.7 bits (76), Expect = 2.6
 Identities = 25/88 (28%), Positives = 35/88 (39%)

Query: 404 PPNTSIKILVHHAHSDEPITFTSDVESKVEHVILTVVCSLDEDIREDMSGYMLRVRGAKE 463
           P N   K  +   H   P    ++   K    +L     L   + E    Y+L+V G  E
Sbjct: 200 PNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDE 259

Query: 464 YLTPGSSLSEYDYIRECVRLEKDVTLCL 491
           Y      LS+Y YIR C+ L +   L L
Sbjct: 260 YFLEKYPLSQYKYIRSCIMLGRMPNLML 287


>BC113603-1|AAI13604.1| 1068|Homo sapiens phosphoinositide-3-kinase,
            catalytic, alpha polypeptide protein.
          Length = 1068

 Score =  183 bits (446), Expect = 4e-45
 Identities = 104/256 (40%), Positives = 149/256 (58%), Gaps = 16/256 (6%)

Query: 1131 PLALHKYVHDLDVKSCTYFSSNTLPLKINFIGTD--NAVI----PAMFKVGDDLRQDALV 1184
            PL     + +L ++ C   SS   PL +N+   D  + ++      +FK GDDLRQD L 
Sbjct: 754  PLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLT 813

Query: 1185 LQVIKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQTEWGLTGS--FK 1242
            LQ+I+IM+ +W   GLDLRM+ +  L   +  G+IE+V  + T+  IQ + GL G+  F 
Sbjct: 814  LQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFN 873

Query: 1243 DKPIAEWLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHI 1302
               + +WL   N  E+ Y  A D FT SCAGY VAT++LGI DRHN NIM+K  G LFHI
Sbjct: 874  SHTLHQWLKDKNKGEI-YDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHI 932

Query: 1303 DFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGER---PTQRFQHFVELCCMAF 1359
            DFG FL   +    +KR    +R PFVLT D + VI+ G +    T+ F+ F E+C  A+
Sbjct: 933  DFGHFLDHKKKKFGYKR----ERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAY 988

Query: 1360 NIVRAHHDHILDLFAL 1375
              +R H +  ++LF++
Sbjct: 989  LAIRQHANLFINLFSM 1004



 Score = 62.9 bits (146), Expect = 8e-09
 Identities = 80/321 (24%), Positives = 127/321 (39%), Gaps = 45/321 (14%)

Query: 694 DEYMFHAQIYHGTRPLKTLRFTQASKIECGGFYPRIIFDTWLNLEDLPVNTLPRESRLVL 753
           D+      IYHG  PL     TQ  ++ C    PR  ++ WLN  D+ +  LPR +RL L
Sbjct: 352 DKIYVRTGIYHGGEPLCDNVNTQ--RVPCSN--PR--WNEWLNY-DIYIPDLPRAARLCL 404

Query: 754 TLHGRTQRTIDSQHPNENSPPSSQEAEDSGDVLYEQVELGWAALQLFDFDGMLSSGNYVL 813
           ++                S    + A++      E   L W  + LFD+   L SG   L
Sbjct: 405 SIC---------------SVKGRKGAKE------EHCPLAWGNINLFDYTDTLVSGKMAL 443

Query: 814 PLW--PTSCDRRXXXXXXXXXXXXXXXXVVNIEIPLYAHT-----------GVKWTSGEE 860
            LW  P   +                   + +E   ++                W+   E
Sbjct: 444 NLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVSRE 503

Query: 861 D--KQKNISLKDLPSFDS-LDGHTQSQLLHLIEQGAYQRMPTECREVMWEKRQYLVQIPG 917
                 +  L +  + D+ L  + + QL  +  +     +  + ++ +W  R Y V IP 
Sbjct: 504 AGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPE 563

Query: 918 ALPLVLLAATNWYGDHREQLIGLLRLWEKPSPLNAMHLLLPCFPDVAVRETAAKLLNE-M 976
            LP +LL+      D   Q+  L++ W    P  AM LL   +PD  VR  A + L + +
Sbjct: 564 ILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYL 623

Query: 977 SDDDLCRVLPQLTQALRHETY 997
           +DD L + L QL Q L++E Y
Sbjct: 624 TDDKLSQYLIQLVQVLKYEQY 644



 Score = 34.7 bits (76), Expect = 2.6
 Identities = 25/88 (28%), Positives = 35/88 (39%)

Query: 404 PPNTSIKILVHHAHSDEPITFTSDVESKVEHVILTVVCSLDEDIREDMSGYMLRVRGAKE 463
           P N   K  +   H   P    ++   K    +L     L   + E    Y+L+V G  E
Sbjct: 200 PNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDE 259

Query: 464 YLTPGSSLSEYDYIRECVRLEKDVTLCL 491
           Y      LS+Y YIR C+ L +   L L
Sbjct: 260 YFLEKYPLSQYKYIRSCIMLGRMPNLML 287


>BC113601-1|AAI13602.1| 1068|Homo sapiens phosphoinositide-3-kinase,
            catalytic, alpha polypeptide protein.
          Length = 1068

 Score =  183 bits (446), Expect = 4e-45
 Identities = 104/256 (40%), Positives = 149/256 (58%), Gaps = 16/256 (6%)

Query: 1131 PLALHKYVHDLDVKSCTYFSSNTLPLKINFIGTD--NAVI----PAMFKVGDDLRQDALV 1184
            PL     + +L ++ C   SS   PL +N+   D  + ++      +FK GDDLRQD L 
Sbjct: 754  PLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLT 813

Query: 1185 LQVIKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQTEWGLTGS--FK 1242
            LQ+I+IM+ +W   GLDLRM+ +  L   +  G+IE+V  + T+  IQ + GL G+  F 
Sbjct: 814  LQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFN 873

Query: 1243 DKPIAEWLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHI 1302
               + +WL   N  E+ Y  A D FT SCAGY VAT++LGI DRHN NIM+K  G LFHI
Sbjct: 874  SHTLHQWLKDKNKGEI-YDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHI 932

Query: 1303 DFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGER---PTQRFQHFVELCCMAF 1359
            DFG FL   +    +KR    +R PFVLT D + VI+ G +    T+ F+ F E+C  A+
Sbjct: 933  DFGHFLDHKKKKFGYKR----ERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAY 988

Query: 1360 NIVRAHHDHILDLFAL 1375
              +R H +  ++LF++
Sbjct: 989  LAIRQHANLFINLFSM 1004



 Score = 62.9 bits (146), Expect = 8e-09
 Identities = 80/321 (24%), Positives = 127/321 (39%), Gaps = 45/321 (14%)

Query: 694 DEYMFHAQIYHGTRPLKTLRFTQASKIECGGFYPRIIFDTWLNLEDLPVNTLPRESRLVL 753
           D+      IYHG  PL     TQ  ++ C    PR  ++ WLN  D+ +  LPR +RL L
Sbjct: 352 DKIYVRTGIYHGGEPLCDNVNTQ--RVPCSN--PR--WNEWLNY-DIYIPDLPRAARLCL 404

Query: 754 TLHGRTQRTIDSQHPNENSPPSSQEAEDSGDVLYEQVELGWAALQLFDFDGMLSSGNYVL 813
           ++                S    + A++      E   L W  + LFD+   L SG   L
Sbjct: 405 SIC---------------SVKGRKGAKE------EHCPLAWGNINLFDYTDTLVSGKMAL 443

Query: 814 PLW--PTSCDRRXXXXXXXXXXXXXXXXVVNIEIPLYAHT-----------GVKWTSGEE 860
            LW  P   +                   + +E   ++                W+   E
Sbjct: 444 NLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVSRE 503

Query: 861 D--KQKNISLKDLPSFDS-LDGHTQSQLLHLIEQGAYQRMPTECREVMWEKRQYLVQIPG 917
                 +  L +  + D+ L  + + QL  +  +     +  + ++ +W  R Y V IP 
Sbjct: 504 AGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPE 563

Query: 918 ALPLVLLAATNWYGDHREQLIGLLRLWEKPSPLNAMHLLLPCFPDVAVRETAAKLLNE-M 976
            LP +LL+      D   Q+  L++ W    P  AM LL   +PD  VR  A + L + +
Sbjct: 564 ILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYL 623

Query: 977 SDDDLCRVLPQLTQALRHETY 997
           +DD L + L QL Q L++E Y
Sbjct: 624 TDDKLSQYLIQLVQVLKYEQY 644



 Score = 34.7 bits (76), Expect = 2.6
 Identities = 25/88 (28%), Positives = 35/88 (39%)

Query: 404 PPNTSIKILVHHAHSDEPITFTSDVESKVEHVILTVVCSLDEDIREDMSGYMLRVRGAKE 463
           P N   K  +   H   P    ++   K    +L     L   + E    Y+L+V G  E
Sbjct: 200 PNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDE 259

Query: 464 YLTPGSSLSEYDYIRECVRLEKDVTLCL 491
           Y      LS+Y YIR C+ L +   L L
Sbjct: 260 YFLEKYPLSQYKYIRSCIMLGRMPNLML 287


>AB210020-1|BAE06102.1| 1069|Homo sapiens PIK3CA variant protein
            protein.
          Length = 1069

 Score =  183 bits (446), Expect = 4e-45
 Identities = 104/256 (40%), Positives = 149/256 (58%), Gaps = 16/256 (6%)

Query: 1131 PLALHKYVHDLDVKSCTYFSSNTLPLKINFIGTD--NAVI----PAMFKVGDDLRQDALV 1184
            PL     + +L ++ C   SS   PL +N+   D  + ++      +FK GDDLRQD L 
Sbjct: 755  PLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLT 814

Query: 1185 LQVIKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQTEWGLTGS--FK 1242
            LQ+I+IM+ +W   GLDLRM+ +  L   +  G+IE+V  + T+  IQ + GL G+  F 
Sbjct: 815  LQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFN 874

Query: 1243 DKPIAEWLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHI 1302
               + +WL   N  E+ Y  A D FT SCAGY VAT++LGI DRHN NIM+K  G LFHI
Sbjct: 875  SHTLHQWLKDKNKGEI-YDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHI 933

Query: 1303 DFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGER---PTQRFQHFVELCCMAF 1359
            DFG FL   +    +KR    +R PFVLT D + VI+ G +    T+ F+ F E+C  A+
Sbjct: 934  DFGHFLDHKKKKFGYKR----ERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAY 989

Query: 1360 NIVRAHHDHILDLFAL 1375
              +R H +  ++LF++
Sbjct: 990  LAIRQHANLFINLFSM 1005



 Score = 62.9 bits (146), Expect = 8e-09
 Identities = 80/321 (24%), Positives = 127/321 (39%), Gaps = 45/321 (14%)

Query: 694 DEYMFHAQIYHGTRPLKTLRFTQASKIECGGFYPRIIFDTWLNLEDLPVNTLPRESRLVL 753
           D+      IYHG  PL     TQ  ++ C    PR  ++ WLN  D+ +  LPR +RL L
Sbjct: 353 DKIYVRTGIYHGGEPLCDNVNTQ--RVPCSN--PR--WNEWLNY-DIYIPDLPRAARLCL 405

Query: 754 TLHGRTQRTIDSQHPNENSPPSSQEAEDSGDVLYEQVELGWAALQLFDFDGMLSSGNYVL 813
           ++                S    + A++      E   L W  + LFD+   L SG   L
Sbjct: 406 SIC---------------SVKGRKGAKE------EHCPLAWGNINLFDYTDTLVSGKMAL 444

Query: 814 PLW--PTSCDRRXXXXXXXXXXXXXXXXVVNIEIPLYAHT-----------GVKWTSGEE 860
            LW  P   +                   + +E   ++                W+   E
Sbjct: 445 NLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVSRE 504

Query: 861 D--KQKNISLKDLPSFDS-LDGHTQSQLLHLIEQGAYQRMPTECREVMWEKRQYLVQIPG 917
                 +  L +  + D+ L  + + QL  +  +     +  + ++ +W  R Y V IP 
Sbjct: 505 AGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPE 564

Query: 918 ALPLVLLAATNWYGDHREQLIGLLRLWEKPSPLNAMHLLLPCFPDVAVRETAAKLLNE-M 976
            LP +LL+      D   Q+  L++ W    P  AM LL   +PD  VR  A + L + +
Sbjct: 565 ILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYL 624

Query: 977 SDDDLCRVLPQLTQALRHETY 997
           +DD L + L QL Q L++E Y
Sbjct: 625 TDDKLSQYLIQLVQVLKYEQY 645



 Score = 34.7 bits (76), Expect = 2.6
 Identities = 25/88 (28%), Positives = 35/88 (39%)

Query: 404 PPNTSIKILVHHAHSDEPITFTSDVESKVEHVILTVVCSLDEDIREDMSGYMLRVRGAKE 463
           P N   K  +   H   P    ++   K    +L     L   + E    Y+L+V G  E
Sbjct: 201 PNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDE 260

Query: 464 YLTPGSSLSEYDYIRECVRLEKDVTLCL 491
           Y      LS+Y YIR C+ L +   L L
Sbjct: 261 YFLEKYPLSQYKYIRSCIMLGRMPNLML 288


>BC003393-1|AAH03393.1|  286|Homo sapiens Unknown (protein for
            IMAGE:3447173) protein.
          Length = 286

 Score =  181 bits (440), Expect = 2e-44
 Identities = 93/212 (43%), Positives = 136/212 (64%), Gaps = 9/212 (4%)

Query: 1168 IPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAET 1227
            +  +FK GDDLRQD L LQ++++MD LW +AGLDLRM+ +  L T +  G+IE+V+ +ET
Sbjct: 16   VGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSET 75

Query: 1228 LRAIQ---TEWGLTGSFKDKPIAEWLAKHNPSELEYQRARDNFTASCAGYSVATYLLGIC 1284
            +  IQ   +      +F    +  WL ++N  + +  RA + FT SCAGY VA+Y+LGI 
Sbjct: 76   IADIQLNSSNVAAAAAFNKDALLNWLKEYNSGD-DLDRAIEEFTLSCAGYCVASYVLGIG 134

Query: 1285 DRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGER- 1343
            DRH+DNIM+K +G LFHIDFG  LG+ +     KR    +R PF+LT+D ++VI  G+  
Sbjct: 135  DRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKR----ERVPFILTYDFIHVIQQGKTG 190

Query: 1344 PTQRFQHFVELCCMAFNIVRAHHDHILDLFAL 1375
             T++F  F + C  A+ I+R H +  + LFAL
Sbjct: 191  NTEKFGRFRQCCEDAYLILRRHGNLFITLFAL 222


>BC053651-1|AAH53651.1|  887|Homo sapiens phosphoinositide-3-kinase,
            class 3 protein.
          Length = 887

 Score =  138 bits (334), Expect = 1e-31
 Identities = 84/246 (34%), Positives = 130/246 (52%), Gaps = 16/246 (6%)

Query: 1130 LPLALHKYVHDLDVKSCTYFSSNTLPLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIK 1189
            LPL     +  +  ++ T F S  +P ++ F   D    P +FK GDDLRQD L+LQ+I 
Sbjct: 593  LPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIIS 652

Query: 1190 IMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQTEWGLTGSFKDKPIAEW 1249
            +MD L  K  LDL++  ++ L TS   G ++ +        + TE  +   F+    +E 
Sbjct: 653  LMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSE- 711

Query: 1250 LAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHIDFGKFLG 1309
               + P+ +  +   D +  SCAGY V TY+LG+ DRH DN++L  +G LFHIDFG  LG
Sbjct: 712  ---NGPNGISAE-VMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILG 767

Query: 1310 DAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGERPTQRFQHFVELCCMAFNIVRAHHDHI 1369
                  + K L      P  L  +MV  + G +  ++++Q F + C  AF  +R + + I
Sbjct: 768  -----RDPKPL----PPPMKLNKEMVEGMGGTQ--SEQYQEFRKQCYTAFLHLRRYSNLI 816

Query: 1370 LDLFAL 1375
            L+LF+L
Sbjct: 817  LNLFSL 822



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 38/134 (28%), Positives = 64/134 (47%), Gaps = 4/134 (2%)

Query: 867 SLKDLPSFDSL--DGHTQSQLLHLIEQGAYQRMPTECREVMWEKRQYLVQIPGALPLVLL 924
           SL+  PS   L  +  T+ QL  ++     +++  E ++++W+ R YL     AL    L
Sbjct: 276 SLRSGPSDHDLKPNAATRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTK-FL 334

Query: 925 AATNW-YGDHREQLIGLLRLWEKPSPLNAMHLLLPCFPDVAVRETAAKLLNEMSDDDLCR 983
              NW      +Q + LL  W+     +++ LL   + +  VR  A   L +  D+DL  
Sbjct: 335 KCVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDEDLLM 394

Query: 984 VLPQLTQALRHETY 997
            L QL QAL++E +
Sbjct: 395 YLLQLVQALKYENF 408


>BC033004-1|AAH33004.1|  887|Homo sapiens phosphoinositide-3-kinase,
            class 3 protein.
          Length = 887

 Score =  138 bits (334), Expect = 1e-31
 Identities = 84/246 (34%), Positives = 130/246 (52%), Gaps = 16/246 (6%)

Query: 1130 LPLALHKYVHDLDVKSCTYFSSNTLPLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIK 1189
            LPL     +  +  ++ T F S  +P ++ F   D    P +FK GDDLRQD L+LQ+I 
Sbjct: 593  LPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIIS 652

Query: 1190 IMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQTEWGLTGSFKDKPIAEW 1249
            +MD L  K  LDL++  ++ L TS   G ++ +        + TE  +   F+    +E 
Sbjct: 653  LMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSE- 711

Query: 1250 LAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHIDFGKFLG 1309
               + P+ +  +   D +  SCAGY V TY+LG+ DRH DN++L  +G LFHIDFG  LG
Sbjct: 712  ---NGPNGISAE-VMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILG 767

Query: 1310 DAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGERPTQRFQHFVELCCMAFNIVRAHHDHI 1369
                  + K L      P  L  +MV  + G +  ++++Q F + C  AF  +R + + I
Sbjct: 768  -----RDPKPL----PPPMKLNKEMVEGMGGTQ--SEQYQEFRKQCYTAFLHLRRYSNLI 816

Query: 1370 LDLFAL 1375
            L+LF+L
Sbjct: 817  LNLFSL 822



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 38/134 (28%), Positives = 64/134 (47%), Gaps = 4/134 (2%)

Query: 867 SLKDLPSFDSL--DGHTQSQLLHLIEQGAYQRMPTECREVMWEKRQYLVQIPGALPLVLL 924
           SL+  PS   L  +  T+ QL  ++     +++  E ++++W+ R YL     AL    L
Sbjct: 276 SLRSGPSDHDLKPNAATRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTK-FL 334

Query: 925 AATNW-YGDHREQLIGLLRLWEKPSPLNAMHLLLPCFPDVAVRETAAKLLNEMSDDDLCR 983
              NW      +Q + LL  W+     +++ LL   + +  VR  A   L +  D+DL  
Sbjct: 335 KCVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDEDLLM 394

Query: 984 VLPQLTQALRHETY 997
            L QL QAL++E +
Sbjct: 395 YLLQLVQALKYENF 408


>Z46973-1|CAA87094.1|  887|Homo sapiens phosphatidylinositol 3-kinase
            protein.
          Length = 887

 Score =  138 bits (333), Expect = 2e-31
 Identities = 84/246 (34%), Positives = 130/246 (52%), Gaps = 16/246 (6%)

Query: 1130 LPLALHKYVHDLDVKSCTYFSSNTLPLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIK 1189
            LPL     +  +  ++ T F S  +P ++ F   D    P +FK GDDLRQD L+LQ+I 
Sbjct: 593  LPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIIS 652

Query: 1190 IMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQTEWGLTGSFKDKPIAEW 1249
            +MD L  K  LDL++  ++ L TS   G ++ +        + TE  +   F+    +E 
Sbjct: 653  LMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSE- 711

Query: 1250 LAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHIDFGKFLG 1309
               + P+ +  +   D +  SCAGY V TY+LG+ DRH DN++L  +G LFHIDFG  LG
Sbjct: 712  ---NGPNGISAE-VMDTYVKSCAGYCVITYILGVGDRHLDNLVLTKTGKLFHIDFGYILG 767

Query: 1310 DAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGERPTQRFQHFVELCCMAFNIVRAHHDHI 1369
                  + K L      P  L  +MV  + G +  ++++Q F + C  AF  +R + + I
Sbjct: 768  -----RDPKPL----PPPMKLNKEMVEGMGGTQ--SEQYQEFRKQCYTAFLHLRRYSNLI 816

Query: 1370 LDLFAL 1375
            L+LF+L
Sbjct: 817  LNLFSL 822



 Score = 51.2 bits (117), Expect = 3e-05
 Identities = 38/142 (26%), Positives = 65/142 (45%), Gaps = 4/142 (2%)

Query: 860 EDKQKNI--SLKDLPSFDSLDGHT--QSQLLHLIEQGAYQRMPTECREVMWEKRQYLVQI 915
           E K  N+  SL+  PS   L  +   + QL +++     +    E ++++WE R YL   
Sbjct: 267 ESKHHNLPRSLRSGPSDHDLKPYPSPRDQLKNIVSYPPSKPPTYEEQDLVWEFRYYLTNQ 326

Query: 916 PGALPLVLLAATNWYGDHREQLIGLLRLWEKPSPLNAMHLLLPCFPDVAVRETAAKLLNE 975
             AL  +L +         +Q + LL  W      +++ L+   + +  VR  A   L +
Sbjct: 327 DKALTKILTSVIWDLPQGAKQALALLGKWNPMDVEDSLELISSHYTNPTVRRYAVARLRQ 386

Query: 976 MSDDDLCRVLPQLTQALRHETY 997
             D+DL   L QL QAL++E +
Sbjct: 387 ADDEDLLMYLSQLVQALKYENF 408


>L36151-1|AAA56839.1|  854|Homo sapiens phosphatidylinositol 4-kinase
            protein.
          Length = 854

 Score =  116 bits (278), Expect = 9e-25
 Identities = 73/208 (35%), Positives = 112/208 (53%), Gaps = 16/208 (7%)

Query: 1170 AMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLR 1229
            A+FKVGDD RQD L LQ+I +   ++   GLDL +  ++ + T+   G+IE + +  +  
Sbjct: 599  AIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRD 658

Query: 1230 AI--QTEWGLTGSFKDKPIAEWLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRH 1287
             +  QT++G+   F  +   E       S L +Q+AR NF  S A YS+  +LL I DRH
Sbjct: 659  QLGRQTDFGMYDYFTRQYGDE-------STLAFQQARYNFIRSMAAYSLLLFLLQIKDRH 711

Query: 1288 NDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGERPTQR 1347
            N NIML   GH+ HIDFG F+ ++   GN      +   P +   D + +I GG+     
Sbjct: 712  NGNIMLDKKGHIIHIDFG-FMFESSPGGN------LGWEPDIKLTDEMVMIMGGKMEATP 764

Query: 1348 FQHFVELCCMAFNIVRAHHDHILDLFAL 1375
            F+ F+E+C   +  VR + D ++ L  L
Sbjct: 765  FKWFMEMCVRGYLAVRPYMDAVVSLVTL 792


>BC018120-1|AAH18120.2|  903|Homo sapiens PIK4CA protein protein.
          Length = 903

 Score =  116 bits (278), Expect = 9e-25
 Identities = 73/208 (35%), Positives = 112/208 (53%), Gaps = 16/208 (7%)

Query: 1170 AMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLR 1229
            A+FKVGDD RQD L LQ+I +   ++   GLDL +  ++ + T+   G+IE + +  +  
Sbjct: 648  AIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRD 707

Query: 1230 AI--QTEWGLTGSFKDKPIAEWLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRH 1287
             +  QT++G+   F  +   E       S L +Q+AR NF  S A YS+  +LL I DRH
Sbjct: 708  QLGRQTDFGMYDYFTRQYGDE-------STLAFQQARYNFIRSMAAYSLLLFLLQIKDRH 760

Query: 1288 NDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGERPTQR 1347
            N NIML   GH+ HIDFG F+ ++   GN      +   P +   D + +I GG+     
Sbjct: 761  NGNIMLDKKGHIIHIDFG-FMFESSPGGN------LGWEPDIKLTDEMVMIMGGKMEATP 813

Query: 1348 FQHFVELCCMAFNIVRAHHDHILDLFAL 1375
            F+ F+E+C   +  VR + D ++ L  L
Sbjct: 814  FKWFMEMCVRGYLAVRPYMDAVVSLVTL 841


>AF012872-1|AAD13352.1| 2044|Homo sapiens phosphatidylinositol
            4-kinase 230 protein.
          Length = 2044

 Score =  116 bits (278), Expect = 9e-25
 Identities = 73/208 (35%), Positives = 112/208 (53%), Gaps = 16/208 (7%)

Query: 1170 AMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLR 1229
            A+FKVGDD RQD L LQ+I +   ++   GLDL +  ++ + T+   G+IE + +  +  
Sbjct: 1789 AIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRD 1848

Query: 1230 AI--QTEWGLTGSFKDKPIAEWLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRH 1287
             +  QT++G+   F  +   E       S L +Q+AR NF  S A YS+  +LL I DRH
Sbjct: 1849 QLGRQTDFGMYDYFTRQYGDE-------STLAFQQARYNFIRSMAAYSLLLFLLQIKDRH 1901

Query: 1288 NDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGERPTQR 1347
            N NIML   GH+ HIDFG F+ ++   GN      +   P +   D + +I GG+     
Sbjct: 1902 NGNIMLDKKGHIIHIDFG-FMFESSPGGN------LGWEPDIKLTDEMVMIMGGKMEATP 1954

Query: 1348 FQHFVELCCMAFNIVRAHHDHILDLFAL 1375
            F+ F+E+C   +  VR + D ++ L  L
Sbjct: 1955 FKWFMEMCVRGYLAVRPYMDAVVSLVTL 1982


>AB210002-1|BAE06084.1| 2121|Homo sapiens PIK4CA variant protein
            protein.
          Length = 2121

 Score =  116 bits (278), Expect = 9e-25
 Identities = 73/208 (35%), Positives = 112/208 (53%), Gaps = 16/208 (7%)

Query: 1170 AMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLR 1229
            A+FKVGDD RQD L LQ+I +   ++   GLDL +  ++ + T+   G+IE + +  +  
Sbjct: 1866 AIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRD 1925

Query: 1230 AI--QTEWGLTGSFKDKPIAEWLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRH 1287
             +  QT++G+   F  +   E       S L +Q+AR NF  S A YS+  +LL I DRH
Sbjct: 1926 QLGRQTDFGMYDYFTRQYGDE-------STLAFQQARYNFIRSMAAYSLLLFLLQIKDRH 1978

Query: 1288 NDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGERPTQR 1347
            N NIML   GH+ HIDFG F+ ++   GN      +   P +   D + +I GG+     
Sbjct: 1979 NGNIMLDKKGHIIHIDFG-FMFESSPGGN------LGWEPDIKLTDEMVMIMGGKMEATP 2031

Query: 1348 FQHFVELCCMAFNIVRAHHDHILDLFAL 1375
            F+ F+E+C   +  VR + D ++ L  L
Sbjct: 2032 FKWFMEMCVRGYLAVRPYMDAVVSLVTL 2059


>BC053654-1|AAH53654.1|  895|Homo sapiens PIK4CA protein protein.
          Length = 895

 Score =  113 bits (272), Expect = 5e-24
 Identities = 72/208 (34%), Positives = 111/208 (53%), Gaps = 16/208 (7%)

Query: 1170 AMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLR 1229
            A+FKVGDD RQD L LQ+I +   ++   GLDL +  ++ + T+   G+IE + +  +  
Sbjct: 640  AIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRD 699

Query: 1230 AI--QTEWGLTGSFKDKPIAEWLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRH 1287
             +  QT++G+   F  +   E       S L +Q+AR NF  S A Y +  +LL I DRH
Sbjct: 700  QLGRQTDFGMYDYFTRQYGDE-------STLAFQQARYNFIRSMAAYILLLFLLQIKDRH 752

Query: 1288 NDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGERPTQR 1347
            N NIML   GH+ HIDFG F+ ++   GN      +   P +   D + +I GG+     
Sbjct: 753  NGNIMLDKKGHIIHIDFG-FMFESSPGGN------LGWEPDIKLTDEMVMIMGGKMEATP 805

Query: 1348 FQHFVELCCMAFNIVRAHHDHILDLFAL 1375
            F+ F+E+C   +  VR + D ++ L  L
Sbjct: 806  FKWFMEMCVRGYLAVRPYMDAVVSLVTL 833


>BC020225-1|AAH20225.2|  539|Homo sapiens LOC220686 protein protein.
          Length = 539

 Score =  109 bits (261), Expect = 1e-22
 Identities = 69/196 (35%), Positives = 106/196 (54%), Gaps = 16/196 (8%)

Query: 1170 AMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLR 1229
            A+FK+GDD RQD L LQ+I +   ++   GLDL +  ++ + T+   G+IE + +  +  
Sbjct: 314  AIFKLGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRD 373

Query: 1230 AI--QTEWGLTGSFKDKPIAEWLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRH 1287
             +  QT++G+   F  +   E       S L +Q+AR NF  S A YS+  +LL I DRH
Sbjct: 374  QLGRQTDFGMYDYFTRQYGDE-------STLAFQQARYNFIRSMAAYSLLLFLLQIKDRH 426

Query: 1288 NDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGERPTQR 1347
            N NIML   GH+ HIDFG F+ ++   GN      +   P +   D + +I GG+     
Sbjct: 427  NGNIMLDKKGHIIHIDFG-FMFESSPGGN------LGWEPDIKLTDEMVMIMGGKMEATP 479

Query: 1348 FQHFVELCCMAFNIVR 1363
            F+ F+E+C   +  VR
Sbjct: 480  FKWFMEMCVRGYLAVR 495


>U81802-1|AAC51156.1|  801|Homo sapiens PtdIns 4-kinase protein.
          Length = 801

 Score = 98.3 bits (234), Expect = 2e-19
 Identities = 65/207 (31%), Positives = 103/207 (49%), Gaps = 15/207 (7%)

Query: 1167 VIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAE 1226
            ++  + K GDDLRQ+ L  QV+K + ++W +  + L +  ++ L  S   GMIE V  A 
Sbjct: 543  LLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAV 602

Query: 1227 TLRAIQTEWGLTGSFKDKPIAEWLAKHNPSELE-YQRARDNFTASCAGYSVATYLLGICD 1285
            ++  ++ +  L  S  D     +L +H     E +  A+ NF  SCAGY +  YLL + D
Sbjct: 603  SIHQVKKQSQL--SLLDY----FLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKD 656

Query: 1286 RHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGERPT 1345
            RHN NI+L   GH+ HIDFG  L  +       R +  + + F LT + V V+ G +   
Sbjct: 657  RHNGNILLDAEGHIIHIDFGFILSSS------PRNLGFETSAFKLTTEFVDVMGGLD--G 708

Query: 1346 QRFQHFVELCCMAFNIVRAHHDHILDL 1372
              F ++  L        R H D ++ +
Sbjct: 709  DMFNYYKMLMLQGLIAARKHMDKVVQI 735


>BC040300-1|AAH40300.1|  801|Homo sapiens PIK4CB protein protein.
          Length = 801

 Score = 98.3 bits (234), Expect = 2e-19
 Identities = 65/207 (31%), Positives = 103/207 (49%), Gaps = 15/207 (7%)

Query: 1167 VIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAE 1226
            ++  + K GDDLRQ+ L  QV+K + ++W +  + L +  ++ L  S   GMIE V  A 
Sbjct: 543  LLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAV 602

Query: 1227 TLRAIQTEWGLTGSFKDKPIAEWLAKHNPSELE-YQRARDNFTASCAGYSVATYLLGICD 1285
            ++  ++ +  L  S  D     +L +H     E +  A+ NF  SCAGY +  YLL + D
Sbjct: 603  SIHQVKKQSQL--SLLDY----FLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKD 656

Query: 1286 RHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGERPT 1345
            RHN NI+L   GH+ HIDFG  L  +       R +  + + F LT + V V+ G +   
Sbjct: 657  RHNGNILLDAEGHIIHIDFGFILSSS------PRNLGFETSAFKLTTEFVDVMGGLD--G 708

Query: 1346 QRFQHFVELCCMAFNIVRAHHDHILDL 1372
              F ++  L        R H D ++ +
Sbjct: 709  DMFNYYKMLMLQGLIAARKHMDKVVQI 735


>BC000029-1|AAH00029.1|  801|Homo sapiens PIK4CB protein protein.
          Length = 801

 Score = 98.3 bits (234), Expect = 2e-19
 Identities = 65/207 (31%), Positives = 103/207 (49%), Gaps = 15/207 (7%)

Query: 1167 VIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAE 1226
            ++  + K GDDLRQ+ L  QV+K + ++W +  + L +  ++ L  S   GMIE V  A 
Sbjct: 543  LLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAV 602

Query: 1227 TLRAIQTEWGLTGSFKDKPIAEWLAKHNPSELE-YQRARDNFTASCAGYSVATYLLGICD 1285
            ++  ++ +  L  S  D     +L +H     E +  A+ NF  SCAGY +  YLL + D
Sbjct: 603  SIHQVKKQSQL--SLLDY----FLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKD 656

Query: 1286 RHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGERPT 1345
            RHN NI+L   GH+ HIDFG  L  +       R +  + + F LT + V V+ G +   
Sbjct: 657  RHNGNILLDAEGHIIHIDFGFILSSS------PRNLGFETSAFKLTTEFVDVMGGLD--G 708

Query: 1346 QRFQHFVELCCMAFNIVRAHHDHILDL 1372
              F ++  L        R H D ++ +
Sbjct: 709  DMFNYYKMLMLQGLIAARKHMDKVVQI 735


>AL391069-7|CAH70326.1|  828|Homo sapiens phosphatidylinositol
            4-kinase, catalytic, beta polypeptide protein.
          Length = 828

 Score = 98.3 bits (234), Expect = 2e-19
 Identities = 65/207 (31%), Positives = 103/207 (49%), Gaps = 15/207 (7%)

Query: 1167 VIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAE 1226
            ++  + K GDDLRQ+ L  QV+K + ++W +  + L +  ++ L  S   GMIE V  A 
Sbjct: 570  LLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAV 629

Query: 1227 TLRAIQTEWGLTGSFKDKPIAEWLAKHNPSELE-YQRARDNFTASCAGYSVATYLLGICD 1285
            ++  ++ +  L  S  D     +L +H     E +  A+ NF  SCAGY +  YLL + D
Sbjct: 630  SIHQVKKQSQL--SLLDY----FLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKD 683

Query: 1286 RHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGERPT 1345
            RHN NI+L   GH+ HIDFG  L  +       R +  + + F LT + V V+ G +   
Sbjct: 684  RHNGNILLDAEGHIIHIDFGFILSSS------PRNLGFETSAFKLTTEFVDVMGGLD--G 735

Query: 1346 QRFQHFVELCCMAFNIVRAHHDHILDL 1372
              F ++  L        R H D ++ +
Sbjct: 736  DMFNYYKMLMLQGLIAARKHMDKVVQI 762


>AL391069-6|CAH70324.1|  816|Homo sapiens phosphatidylinositol
            4-kinase, catalytic, beta polypeptide protein.
          Length = 816

 Score = 98.3 bits (234), Expect = 2e-19
 Identities = 65/207 (31%), Positives = 103/207 (49%), Gaps = 15/207 (7%)

Query: 1167 VIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAE 1226
            ++  + K GDDLRQ+ L  QV+K + ++W +  + L +  ++ L  S   GMIE V  A 
Sbjct: 558  LLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAV 617

Query: 1227 TLRAIQTEWGLTGSFKDKPIAEWLAKHNPSELE-YQRARDNFTASCAGYSVATYLLGICD 1285
            ++  ++ +  L  S  D     +L +H     E +  A+ NF  SCAGY +  YLL + D
Sbjct: 618  SIHQVKKQSQL--SLLDY----FLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKD 671

Query: 1286 RHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGERPT 1345
            RHN NI+L   GH+ HIDFG  L  +       R +  + + F LT + V V+ G +   
Sbjct: 672  RHNGNILLDAEGHIIHIDFGFILSSS------PRNLGFETSAFKLTTEFVDVMGGLD--G 723

Query: 1346 QRFQHFVELCCMAFNIVRAHHDHILDL 1372
              F ++  L        R H D ++ +
Sbjct: 724  DMFNYYKMLMLQGLIAARKHMDKVVQI 750


>AL391069-5|CAH70325.1|  801|Homo sapiens phosphatidylinositol
            4-kinase, catalytic, beta polypeptide protein.
          Length = 801

 Score = 98.3 bits (234), Expect = 2e-19
 Identities = 65/207 (31%), Positives = 103/207 (49%), Gaps = 15/207 (7%)

Query: 1167 VIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAE 1226
            ++  + K GDDLRQ+ L  QV+K + ++W +  + L +  ++ L  S   GMIE V  A 
Sbjct: 543  LLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAV 602

Query: 1227 TLRAIQTEWGLTGSFKDKPIAEWLAKHNPSELE-YQRARDNFTASCAGYSVATYLLGICD 1285
            ++  ++ +  L  S  D     +L +H     E +  A+ NF  SCAGY +  YLL + D
Sbjct: 603  SIHQVKKQSQL--SLLDY----FLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKD 656

Query: 1286 RHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGERPT 1345
            RHN NI+L   GH+ HIDFG  L  +       R +  + + F LT + V V+ G +   
Sbjct: 657  RHNGNILLDAEGHIIHIDFGFILSSS------PRNLGFETSAFKLTTEFVDVMGGLD--G 708

Query: 1346 QRFQHFVELCCMAFNIVRAHHDHILDL 1372
              F ++  L        R H D ++ +
Sbjct: 709  DMFNYYKMLMLQGLIAARKHMDKVVQI 735


>AJ011123-1|CAA09496.1|  816|Homo sapiens NPIK-C protein protein.
          Length = 816

 Score = 98.3 bits (234), Expect = 2e-19
 Identities = 65/207 (31%), Positives = 103/207 (49%), Gaps = 15/207 (7%)

Query: 1167 VIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAE 1226
            ++  + K GDDLRQ+ L  QV+K + ++W +  + L +  ++ L  S   GMIE V  A 
Sbjct: 558  LLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAV 617

Query: 1227 TLRAIQTEWGLTGSFKDKPIAEWLAKHNPSELE-YQRARDNFTASCAGYSVATYLLGICD 1285
            ++  ++ +  L  S  D     +L +H     E +  A+ NF  SCAGY +  YLL + D
Sbjct: 618  SIHQVKKQSQL--SLLDY----FLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKD 671

Query: 1286 RHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGERPT 1345
            RHN NI+L   GH+ HIDFG  L  +       R +  + + F LT + V V+ G +   
Sbjct: 672  RHNGNILLDAEGHIIHIDFGFILSSS------PRNLGFETSAFKLTTEFVDVMGGLD--G 723

Query: 1346 QRFQHFVELCCMAFNIVRAHHDHILDL 1372
              F ++  L        R H D ++ +
Sbjct: 724  DMFNYYKMLMLQGLIAARKHMDKVVQI 750


>AJ011121-1|CAA09495.1|  816|Homo sapiens NPIK-A protein protein.
          Length = 816

 Score = 98.3 bits (234), Expect = 2e-19
 Identities = 65/207 (31%), Positives = 103/207 (49%), Gaps = 15/207 (7%)

Query: 1167 VIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAE 1226
            ++  + K GDDLRQ+ L  QV+K + ++W +  + L +  ++ L  S   GMIE V  A 
Sbjct: 558  LLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAV 617

Query: 1227 TLRAIQTEWGLTGSFKDKPIAEWLAKHNPSELE-YQRARDNFTASCAGYSVATYLLGICD 1285
            ++  ++ +  L  S  D     +L +H     E +  A+ NF  SCAGY +  YLL + D
Sbjct: 618  SIHQVKKQSQL--SLLDY----FLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKD 671

Query: 1286 RHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGERPT 1345
            RHN NI+L   GH+ HIDFG  L  +       R +  + + F LT + V V+ G +   
Sbjct: 672  RHNGNILLDAEGHIIHIDFGFILSSS------PRNLGFETSAFKLTTEFVDVMGGLD--G 723

Query: 1346 QRFQHFVELCCMAFNIVRAHHDHILDL 1372
              F ++  L        R H D ++ +
Sbjct: 724  DMFNYYKMLMLQGLIAARKHMDKVVQI 750


>AB005910-1|BAA21661.1|  828|Homo sapiens phosphatidylinositol
            4-kinase protein.
          Length = 828

 Score = 98.3 bits (234), Expect = 2e-19
 Identities = 65/207 (31%), Positives = 103/207 (49%), Gaps = 15/207 (7%)

Query: 1167 VIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAE 1226
            ++  + K GDDLRQ+ L  QV+K + ++W +  + L +  ++ L  S   GMIE V  A 
Sbjct: 570  LLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAV 629

Query: 1227 TLRAIQTEWGLTGSFKDKPIAEWLAKHNPSELE-YQRARDNFTASCAGYSVATYLLGICD 1285
            ++  ++ +  L  S  D     +L +H     E +  A+ NF  SCAGY +  YLL + D
Sbjct: 630  SIHQVKKQSQL--SLLDY----FLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKD 683

Query: 1286 RHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGERPT 1345
            RHN NI+L   GH+ HIDFG  L  +       R +  + + F LT + V V+ G +   
Sbjct: 684  RHNGNILLDAEGHIIHIDFGFILSSS------PRNLGFETSAFKLTTEFVDVMGGLD--G 735

Query: 1346 QRFQHFVELCCMAFNIVRAHHDHILDL 1372
              F ++  L        R H D ++ +
Sbjct: 736  DMFNYYKMLMLQGLIAARKHMDKVVQI 762


>CR456378-1|CAG30264.1|  592|Homo sapiens Em:AP000557.3 protein.
          Length = 592

 Score = 89.0 bits (211), Expect = 1e-16
 Identities = 60/181 (33%), Positives = 94/181 (51%), Gaps = 16/181 (8%)

Query: 1180 QDALVLQVIKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAI--QTEWGL 1237
            QD L LQ+I +   ++   GLDL +  ++ + T+   G+IE + +  +   +  QT++G+
Sbjct: 344  QDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDFGM 403

Query: 1238 TGSFKDKPIAEWLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSG 1297
               F  +   E       S L +Q+A  NF  S A YS+  +LL I DRHN NIML   G
Sbjct: 404  YDYFTRQYGDE-------STLAFQQACYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKG 456

Query: 1298 HLFHIDFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGERPTQRFQHFVELCCM 1357
            H+ HIDFG F+ ++   GN      +   P +   D + +I GG+     F+ F+E+C  
Sbjct: 457  HIIHIDFG-FMFESSPGGN------LGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVQ 509

Query: 1358 A 1358
            A
Sbjct: 510  A 510


>BC139841-1|AAI39842.2|  597|Homo sapiens LOC375133 protein protein.
          Length = 597

 Score = 89.0 bits (211), Expect = 1e-16
 Identities = 60/181 (33%), Positives = 94/181 (51%), Gaps = 16/181 (8%)

Query: 1180 QDALVLQVIKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAI--QTEWGL 1237
            QD L LQ+I +   ++   GLDL +  ++ + T+   G+IE + +  +   +  QT++G+
Sbjct: 344  QDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDFGM 403

Query: 1238 TGSFKDKPIAEWLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSG 1297
               F  +   E       S L +Q+A  NF  S A YS+  +LL I DRHN NIML   G
Sbjct: 404  YDYFTRQYGDE-------STLAFQQACYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKG 456

Query: 1298 HLFHIDFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGERPTQRFQHFVELCCM 1357
            H+ HIDFG F+ ++   GN      +   P +   D + +I GG+     F+ F+E+C  
Sbjct: 457  HIIHIDFG-FMFESSPGGN------LGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVQ 509

Query: 1358 A 1358
            A
Sbjct: 510  A 510


>AY496423-1|AAS75801.1|  104|Homo sapiens phosphoinositide-3-kinase
            gamma polypeptide protein.
          Length = 104

 Score = 60.5 bits (140), Expect = 4e-08
 Identities = 31/84 (36%), Positives = 48/84 (57%), Gaps = 5/84 (5%)

Query: 1141 LDVKSCTYFSSNTLPLKINFIGTD-----NAVIPAMFKVGDDLRQDALVLQVIKIMDTLW 1195
            L ++ C   +S   PL + F   D     N  I  +FK GDDLRQD L+LQ+++IM+++W
Sbjct: 21   LAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIW 80

Query: 1196 LKAGLDLRMVTFQALPTSNSKGMI 1219
                LDL ++ +  + T +  GMI
Sbjct: 81   ETESLDLCLLPYGCISTGDKIGMI 104


>BC022049-1|AAH22049.1|  139|Homo sapiens PIK3CB protein protein.
          Length = 139

 Score = 58.0 bits (134), Expect = 2e-07
 Identities = 32/78 (41%), Positives = 47/78 (60%), Gaps = 5/78 (6%)

Query: 1299 LFHIDFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGER-PTQRFQHFVELCCM 1357
            LFHIDFG  LG+ +     KR    +R PF+LT+D ++VI  G+   T++F  F + C  
Sbjct: 2    LFHIDFGHILGNFKSKFGIKR----ERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCED 57

Query: 1358 AFNIVRAHHDHILDLFAL 1375
            A+ I+R H +  + LFAL
Sbjct: 58   AYLILRRHGNLFITLFAL 75


>U88966-1|AAC39933.1| 2548|Homo sapiens rapamycin associated protein
            FRAP2 protein.
          Length = 2548

 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 39/123 (31%), Positives = 59/123 (47%), Gaps = 12/123 (9%)

Query: 1249 WLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIML-KTSGHLFHIDFGKF 1307
            WL K   SE+ + R R N+T S A  S+  Y+LG+ DRH  N+ML + SG + HIDFG  
Sbjct: 2303 WL-KSPSSEVWFDR-RTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDC 2360

Query: 1308 LGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGERPTQRFQHFVELCCMAFNIVRAHHD 1367
               A       R  + ++ PF LT     ++      T    ++   C     ++R H D
Sbjct: 2361 FEVA-----MTREKFPEKIPFRLTR----MLTNAMEVTGLDGNYRITCHTVMEVLREHKD 2411

Query: 1368 HIL 1370
             ++
Sbjct: 2412 SVM 2414



 Score = 40.3 bits (90), Expect = 0.051
 Identities = 25/91 (27%), Positives = 44/91 (48%), Gaps = 4/91 (4%)

Query: 1145 SCTYFSSNTLPLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLR- 1203
            S    +S   P K+  +G++      + K  +DLRQD  V+Q+  +++TL       LR 
Sbjct: 2158 SLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRK 2217

Query: 1204 ---MVTFQALPTSNSKGMIEIVTEAETLRAI 1231
               +  +  +P S + G+I  V   +TL A+
Sbjct: 2218 NLSIQRYAVIPLSTNSGLIGWVPHCDTLHAL 2248


>L34075-1|AAA58486.1| 2549|Homo sapiens FKBP-rapamycin associated
            protein protein.
          Length = 2549

 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 39/123 (31%), Positives = 59/123 (47%), Gaps = 12/123 (9%)

Query: 1249 WLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIML-KTSGHLFHIDFGKF 1307
            WL K   SE+ + R R N+T S A  S+  Y+LG+ DRH  N+ML + SG + HIDFG  
Sbjct: 2304 WL-KSPSSEVWFDR-RTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDC 2361

Query: 1308 LGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGERPTQRFQHFVELCCMAFNIVRAHHD 1367
               A       R  + ++ PF LT     ++      T    ++   C     ++R H D
Sbjct: 2362 FEVA-----MTREKFPEKIPFRLTR----MLTNAMEVTGLDGNYRITCHTVMEVLREHKD 2412

Query: 1368 HIL 1370
             ++
Sbjct: 2413 SVM 2415



 Score = 40.3 bits (90), Expect = 0.051
 Identities = 25/91 (27%), Positives = 44/91 (48%), Gaps = 4/91 (4%)

Query: 1145 SCTYFSSNTLPLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLR- 1203
            S    +S   P K+  +G++      + K  +DLRQD  V+Q+  +++TL       LR 
Sbjct: 2159 SLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRK 2218

Query: 1204 ---MVTFQALPTSNSKGMIEIVTEAETLRAI 1231
               +  +  +P S + G+I  V   +TL A+
Sbjct: 2219 NLSIQRYAVIPLSTNSGLIGWVPHCDTLHAL 2249


>BC117166-1|AAI17167.1| 2549|Homo sapiens FK506 binding protein
            12-rapamycin associated protein 1 protein.
          Length = 2549

 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 39/123 (31%), Positives = 59/123 (47%), Gaps = 12/123 (9%)

Query: 1249 WLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIML-KTSGHLFHIDFGKF 1307
            WL K   SE+ + R R N+T S A  S+  Y+LG+ DRH  N+ML + SG + HIDFG  
Sbjct: 2304 WL-KSPSSEVWFDR-RTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDC 2361

Query: 1308 LGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGERPTQRFQHFVELCCMAFNIVRAHHD 1367
               A       R  + ++ PF LT     ++      T    ++   C     ++R H D
Sbjct: 2362 FEVA-----MTREKFPEKIPFRLTR----MLTNAMEVTGLDGNYRITCHTVMEVLREHKD 2412

Query: 1368 HIL 1370
             ++
Sbjct: 2413 SVM 2415



 Score = 40.3 bits (90), Expect = 0.051
 Identities = 25/91 (27%), Positives = 44/91 (48%), Gaps = 4/91 (4%)

Query: 1145 SCTYFSSNTLPLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLR- 1203
            S    +S   P K+  +G++      + K  +DLRQD  V+Q+  +++TL       LR 
Sbjct: 2159 SLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRK 2218

Query: 1204 ---MVTFQALPTSNSKGMIEIVTEAETLRAI 1231
               +  +  +P S + G+I  V   +TL A+
Sbjct: 2219 NLSIQRYAVIPLSTNSGLIGWVPHCDTLHAL 2249


>AL391561-2|CAI17228.1| 2549|Homo sapiens FK506 binding protein
            12-rapamycin associated protein 1 protein.
          Length = 2549

 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 39/123 (31%), Positives = 59/123 (47%), Gaps = 12/123 (9%)

Query: 1249 WLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIML-KTSGHLFHIDFGKF 1307
            WL K   SE+ + R R N+T S A  S+  Y+LG+ DRH  N+ML + SG + HIDFG  
Sbjct: 2304 WL-KSPSSEVWFDR-RTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDC 2361

Query: 1308 LGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGERPTQRFQHFVELCCMAFNIVRAHHD 1367
               A       R  + ++ PF LT     ++      T    ++   C     ++R H D
Sbjct: 2362 FEVA-----MTREKFPEKIPFRLTR----MLTNAMEVTGLDGNYRITCHTVMEVLREHKD 2412

Query: 1368 HIL 1370
             ++
Sbjct: 2413 SVM 2415



 Score = 40.3 bits (90), Expect = 0.051
 Identities = 25/91 (27%), Positives = 44/91 (48%), Gaps = 4/91 (4%)

Query: 1145 SCTYFSSNTLPLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLR- 1203
            S    +S   P K+  +G++      + K  +DLRQD  V+Q+  +++TL       LR 
Sbjct: 2159 SLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRK 2218

Query: 1204 ---MVTFQALPTSNSKGMIEIVTEAETLRAI 1231
               +  +  +P S + G+I  V   +TL A+
Sbjct: 2219 NLSIQRYAVIPLSTNSGLIGWVPHCDTLHAL 2249


>AL391561-1|CAI17227.1|  754|Homo sapiens FK506 binding protein
            12-rapamycin associated protein 1 protein.
          Length = 754

 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 39/123 (31%), Positives = 59/123 (47%), Gaps = 12/123 (9%)

Query: 1249 WLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIML-KTSGHLFHIDFGKF 1307
            WL K   SE+ + R R N+T S A  S+  Y+LG+ DRH  N+ML + SG + HIDFG  
Sbjct: 509  WL-KSPSSEVWFDR-RTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDC 566

Query: 1308 LGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGERPTQRFQHFVELCCMAFNIVRAHHD 1367
               A       R  + ++ PF LT     ++      T    ++   C     ++R H D
Sbjct: 567  FEVA-----MTREKFPEKIPFRLTR----MLTNAMEVTGLDGNYRITCHTVMEVLREHKD 617

Query: 1368 HIL 1370
             ++
Sbjct: 618  SVM 620



 Score = 40.3 bits (90), Expect = 0.051
 Identities = 25/91 (27%), Positives = 44/91 (48%), Gaps = 4/91 (4%)

Query: 1145 SCTYFSSNTLPLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLR- 1203
            S    +S   P K+  +G++      + K  +DLRQD  V+Q+  +++TL       LR 
Sbjct: 364  SLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRK 423

Query: 1204 ---MVTFQALPTSNSKGMIEIVTEAETLRAI 1231
               +  +  +P S + G+I  V   +TL A+
Sbjct: 424  NLSIQRYAVIPLSTNSGLIGWVPHCDTLHAL 454


>AL109811-7|CAI22105.1| 2549|Homo sapiens FK506 binding protein
            12-rapamycin associated protein 1 protein.
          Length = 2549

 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 39/123 (31%), Positives = 59/123 (47%), Gaps = 12/123 (9%)

Query: 1249 WLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIML-KTSGHLFHIDFGKF 1307
            WL K   SE+ + R R N+T S A  S+  Y+LG+ DRH  N+ML + SG + HIDFG  
Sbjct: 2304 WL-KSPSSEVWFDR-RTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDC 2361

Query: 1308 LGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGERPTQRFQHFVELCCMAFNIVRAHHD 1367
               A       R  + ++ PF LT     ++      T    ++   C     ++R H D
Sbjct: 2362 FEVA-----MTREKFPEKIPFRLTR----MLTNAMEVTGLDGNYRITCHTVMEVLREHKD 2412

Query: 1368 HIL 1370
             ++
Sbjct: 2413 SVM 2415



 Score = 40.3 bits (90), Expect = 0.051
 Identities = 25/91 (27%), Positives = 44/91 (48%), Gaps = 4/91 (4%)

Query: 1145 SCTYFSSNTLPLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLR- 1203
            S    +S   P K+  +G++      + K  +DLRQD  V+Q+  +++TL       LR 
Sbjct: 2159 SLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRK 2218

Query: 1204 ---MVTFQALPTSNSKGMIEIVTEAETLRAI 1231
               +  +  +P S + G+I  V   +TL A+
Sbjct: 2219 NLSIQRYAVIPLSTNSGLIGWVPHCDTLHAL 2249


>AL109811-3|CAI22101.1|  754|Homo sapiens FK506 binding protein
            12-rapamycin associated protein 1 protein.
          Length = 754

 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 39/123 (31%), Positives = 59/123 (47%), Gaps = 12/123 (9%)

Query: 1249 WLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIML-KTSGHLFHIDFGKF 1307
            WL K   SE+ + R R N+T S A  S+  Y+LG+ DRH  N+ML + SG + HIDFG  
Sbjct: 509  WL-KSPSSEVWFDR-RTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDC 566

Query: 1308 LGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGERPTQRFQHFVELCCMAFNIVRAHHD 1367
               A       R  + ++ PF LT     ++      T    ++   C     ++R H D
Sbjct: 567  FEVA-----MTREKFPEKIPFRLTR----MLTNAMEVTGLDGNYRITCHTVMEVLREHKD 617

Query: 1368 HIL 1370
             ++
Sbjct: 618  SVM 620



 Score = 40.3 bits (90), Expect = 0.051
 Identities = 25/91 (27%), Positives = 44/91 (48%), Gaps = 4/91 (4%)

Query: 1145 SCTYFSSNTLPLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLR- 1203
            S    +S   P K+  +G++      + K  +DLRQD  V+Q+  +++TL       LR 
Sbjct: 364  SLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRK 423

Query: 1204 ---MVTFQALPTSNSKGMIEIVTEAETLRAI 1231
               +  +  +P S + G+I  V   +TL A+
Sbjct: 424  NLSIQRYAVIPLSTNSGLIGWVPHCDTLHAL 454


>AL049653-2|CAI22145.1| 2549|Homo sapiens FK506 binding protein
            12-rapamycin associated protein 1 protein.
          Length = 2549

 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 39/123 (31%), Positives = 59/123 (47%), Gaps = 12/123 (9%)

Query: 1249 WLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIML-KTSGHLFHIDFGKF 1307
            WL K   SE+ + R R N+T S A  S+  Y+LG+ DRH  N+ML + SG + HIDFG  
Sbjct: 2304 WL-KSPSSEVWFDR-RTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDC 2361

Query: 1308 LGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGERPTQRFQHFVELCCMAFNIVRAHHD 1367
               A       R  + ++ PF LT     ++      T    ++   C     ++R H D
Sbjct: 2362 FEVA-----MTREKFPEKIPFRLTR----MLTNAMEVTGLDGNYRITCHTVMEVLREHKD 2412

Query: 1368 HIL 1370
             ++
Sbjct: 2413 SVM 2415



 Score = 40.3 bits (90), Expect = 0.051
 Identities = 25/91 (27%), Positives = 44/91 (48%), Gaps = 4/91 (4%)

Query: 1145 SCTYFSSNTLPLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLR- 1203
            S    +S   P K+  +G++      + K  +DLRQD  V+Q+  +++TL       LR 
Sbjct: 2159 SLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRK 2218

Query: 1204 ---MVTFQALPTSNSKGMIEIVTEAETLRAI 1231
               +  +  +P S + G+I  V   +TL A+
Sbjct: 2219 NLSIQRYAVIPLSTNSGLIGWVPHCDTLHAL 2249


>AJ300188-3|CAC15570.1| 1188|Homo sapiens rapamycin associated protein
            FRAP2 protein.
          Length = 1188

 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 39/123 (31%), Positives = 59/123 (47%), Gaps = 12/123 (9%)

Query: 1249 WLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIML-KTSGHLFHIDFGKF 1307
            WL K   SE+ + R R N+T S A  S+  Y+LG+ DRH  N+ML + SG + HIDFG  
Sbjct: 943  WL-KSPSSEVWFDR-RTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDC 1000

Query: 1308 LGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGERPTQRFQHFVELCCMAFNIVRAHHD 1367
               A       R  + ++ PF LT     ++      T    ++   C     ++R H D
Sbjct: 1001 FEVA-----MTREKFPEKIPFRLTR----MLTNAMEVTGLDGNYRITCHTVMEVLREHKD 1051

Query: 1368 HIL 1370
             ++
Sbjct: 1052 SVM 1054



 Score = 40.3 bits (90), Expect = 0.051
 Identities = 25/91 (27%), Positives = 44/91 (48%), Gaps = 4/91 (4%)

Query: 1145 SCTYFSSNTLPLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLR- 1203
            S    +S   P K+  +G++      + K  +DLRQD  V+Q+  +++TL       LR 
Sbjct: 798  SLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRK 857

Query: 1204 ---MVTFQALPTSNSKGMIEIVTEAETLRAI 1231
               +  +  +P S + G+I  V   +TL A+
Sbjct: 858  NLSIQRYAVIPLSTNSGLIGWVPHCDTLHAL 888


>AB209995-1|BAE06077.1| 2583|Homo sapiens FRAP1 variant protein
            protein.
          Length = 2583

 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 39/123 (31%), Positives = 59/123 (47%), Gaps = 12/123 (9%)

Query: 1249 WLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIML-KTSGHLFHIDFGKF 1307
            WL K   SE+ + R R N+T S A  S+  Y+LG+ DRH  N+ML + SG + HIDFG  
Sbjct: 2338 WL-KSPSSEVWFDR-RTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDC 2395

Query: 1308 LGDAQMFGNFKRLVYIDRAPFVLTHDMVYVINGGERPTQRFQHFVELCCMAFNIVRAHHD 1367
               A       R  + ++ PF LT     ++      T    ++   C     ++R H D
Sbjct: 2396 FEVA-----MTREKFPEKIPFRLTR----MLTNAMEVTGLDGNYRITCHTVMEVLREHKD 2446

Query: 1368 HIL 1370
             ++
Sbjct: 2447 SVM 2449



 Score = 40.3 bits (90), Expect = 0.051
 Identities = 25/91 (27%), Positives = 44/91 (48%), Gaps = 4/91 (4%)

Query: 1145 SCTYFSSNTLPLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLR- 1203
            S    +S   P K+  +G++      + K  +DLRQD  V+Q+  +++TL       LR 
Sbjct: 2193 SLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRK 2252

Query: 1204 ---MVTFQALPTSNSKGMIEIVTEAETLRAI 1231
               +  +  +P S + G+I  V   +TL A+
Sbjct: 2253 NLSIQRYAVIPLSTNSGLIGWVPHCDTLHAL 2283


>AK126860-1|BAC86726.1|  439|Homo sapiens protein ( Homo sapiens cDNA
            FLJ44912 fis, clone BRAMY3009491, highly  similar to
            Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67). ).
          Length = 439

 Score = 50.0 bits (114), Expect = 6e-05
 Identities = 25/74 (33%), Positives = 44/74 (59%), Gaps = 2/74 (2%)

Query: 1170 AMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLR 1229
            A+FK+GDD RQD L LQ+I +   ++   GLDL +  ++ + T+   G+IE + +  +  
Sbjct: 314  AIFKLGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRD 373

Query: 1230 AI--QTEWGLTGSF 1241
             +  QT++G+   F
Sbjct: 374  QLGRQTDFGMYDYF 387


>Y09077-1|CAA70298.1| 2644|Homo sapiens atr protein.
          Length = 2644

 Score = 48.4 bits (110), Expect = 2e-04
 Identities = 59/218 (27%), Positives = 92/218 (42%), Gaps = 43/218 (19%)

Query: 1155 PLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAG----LDLRMVTFQAL 1210
            P KI+  G+D      M K  DDLR+D  +++   +++    K       +L + T+  +
Sbjct: 2309 PKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVI 2368

Query: 1211 PTSNSKGMIEIVTEAETLRAIQT----EWG--LTG--------------SFKDKPIAEWL 1250
            P ++  G+IE V     LR I T    E G  +TG              S K K   E+L
Sbjct: 2369 PLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFL 2428

Query: 1251 AKHNP------------SELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKT-SG 1297
               +P                +  +R  +  S A  S+  Y+LG+ DRH +NI+  + +G
Sbjct: 2429 LPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTG 2488

Query: 1298 HLFHIDFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMV 1335
               H+DF       + F     +V     PF LTH+MV
Sbjct: 2489 ECVHVDFNCLFNKGETF-EVPEIV-----PFRLTHNMV 2520


>U76308-1|AAC50929.1| 2644|Homo sapiens protein kinase ATR protein.
          Length = 2644

 Score = 48.4 bits (110), Expect = 2e-04
 Identities = 59/218 (27%), Positives = 92/218 (42%), Gaps = 43/218 (19%)

Query: 1155 PLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAG----LDLRMVTFQAL 1210
            P KI+  G+D      M K  DDLR+D  +++   +++    K       +L + T+  +
Sbjct: 2309 PKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVI 2368

Query: 1211 PTSNSKGMIEIVTEAETLRAIQT----EWG--LTG--------------SFKDKPIAEWL 1250
            P ++  G+IE V     LR I T    E G  +TG              S K K   E+L
Sbjct: 2369 PLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFL 2428

Query: 1251 AKHNP------------SELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKT-SG 1297
               +P                +  +R  +  S A  S+  Y+LG+ DRH +NI+  + +G
Sbjct: 2429 LPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTG 2488

Query: 1298 HLFHIDFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMV 1335
               H+DF       + F     +V     PF LTH+MV
Sbjct: 2489 ECVHVDFNCLFNKGETF-EVPEIV-----PFRLTHNMV 2520


>U49844-1|AAC50405.1| 2644|Homo sapiens FRAP-related protein protein.
          Length = 2644

 Score = 48.4 bits (110), Expect = 2e-04
 Identities = 59/218 (27%), Positives = 92/218 (42%), Gaps = 43/218 (19%)

Query: 1155 PLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAG----LDLRMVTFQAL 1210
            P KI+  G+D      M K  DDLR+D  +++   +++    K       +L + T+  +
Sbjct: 2309 PKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVI 2368

Query: 1211 PTSNSKGMIEIVTEAETLRAIQT----EWG--LTG--------------SFKDKPIAEWL 1250
            P ++  G+IE V     LR I T    E G  +TG              S K K   E+L
Sbjct: 2369 PLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFL 2428

Query: 1251 AKHNP------------SELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKT-SG 1297
               +P                +  +R  +  S A  S+  Y+LG+ DRH +NI+  + +G
Sbjct: 2429 LPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTG 2488

Query: 1298 HLFHIDFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMV 1335
               H+DF       + F     +V     PF LTH+MV
Sbjct: 2489 ECVHVDFNCLFNKGETF-EVPEIV-----PFRLTHNMV 2520


>AB208847-1|BAD92084.1|  456|Homo sapiens ataxia telangiectasia and
            Rad3 related protein variant protein.
          Length = 456

 Score = 48.4 bits (110), Expect = 2e-04
 Identities = 59/218 (27%), Positives = 92/218 (42%), Gaps = 43/218 (19%)

Query: 1155 PLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAG----LDLRMVTFQAL 1210
            P KI+  G+D      M K  DDLR+D  +++   +++    K       +L + T+  +
Sbjct: 155  PKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVI 214

Query: 1211 PTSNSKGMIEIVTEAETLRAIQT----EWG--LTG--------------SFKDKPIAEWL 1250
            P ++  G+IE V     LR I T    E G  +TG              S K K   E+L
Sbjct: 215  PLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFL 274

Query: 1251 AKHNP------------SELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKT-SG 1297
               +P                +  +R  +  S A  S+  Y+LG+ DRH +NI+  + +G
Sbjct: 275  LPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTG 334

Query: 1298 HLFHIDFGKFLGDAQMFGNFKRLVYIDRAPFVLTHDMV 1335
               H+DF       + F     +V     PF LTH+MV
Sbjct: 335  ECVHVDFNCLFNKGETF-EVPEIV-----PFRLTHNMV 366


>DQ109556-1|AAZ99795.1|  911|Homo sapiens adaptor protein HOFI
            protein.
          Length = 911

 Score = 41.5 bits (93), Expect = 0.022
 Identities = 20/56 (35%), Positives = 32/56 (57%), Gaps = 1/56 (1%)

Query: 1445 LVSVECLGYEKRYDPEKHYVYALRIYRLGQATPSVLYRSYKHFTELYQKICLHFPL 1500
            +V V+ L  +KR  P KHYVY +R+     +T ++ YR Y  F +L  ++   FP+
Sbjct: 7    IVEVKVLDVQKRRVPNKHYVYVIRVTWSSGSTEAI-YRRYSKFFDLQMQMLDKFPM 61


>U35835-1|AAA79184.1|  930|Homo sapiens DNA-PK protein.
          Length = 930

 Score = 40.7 bits (91), Expect = 0.039
 Identities = 38/139 (27%), Positives = 66/139 (47%), Gaps = 12/139 (8%)

Query: 1147 TYFSSNTLPLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLK----AGLDL 1202
            T  +S   P +I   G D    P + K G+DLRQD  V Q+ ++M+ +  +    +   L
Sbjct: 529  TVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRAL 588

Query: 1203 RMVTFQALPTSNSKGMIEIVTEAETLRAIQTEWGLTGSFKDKPIAEWLAKHNPSELEYQR 1262
            ++ T+  +P ++  G+IE +    TL+ +   W  T S ++K  A +L+       EY  
Sbjct: 589  QLRTYSVVPMTSRLGLIEWLENTVTLKDLL--WN-TMSQEEK--AAYLSDPRAPPCEY-- 641

Query: 1263 ARDNFTASCAGYSVATYLL 1281
             +D  T     + V  Y+L
Sbjct: 642  -KDWLTKMSGKHDVGAYML 659



 Score = 37.5 bits (83), Expect = 0.36
 Identities = 20/52 (38%), Positives = 30/52 (57%), Gaps = 1/52 (1%)

Query: 1264 RDNFTASCAGYSVATYLLGICDRHNDNIML-KTSGHLFHIDFGKFLGDAQMF 1314
            R +F +S A   ++ ++LGI DRH +N M+   +G +  IDFG   G A  F
Sbjct: 703  RSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQF 754


>AY014957-1|AAK00511.1| 3031|Homo sapiens PI-3-kinase-related kinase
            SMG-1 protein.
          Length = 3031

 Score = 40.7 bits (91), Expect = 0.039
 Identities = 23/77 (29%), Positives = 41/77 (53%), Gaps = 7/77 (9%)

Query: 1259 EYQRARDNFTASCAGYSVATYLLGICDRHNDNIML-KTSGHLFHIDFGKFLGDAQMFGNF 1317
            E+ R   ++  S A  S+  Y++G+ DRH DN+++  T+G + HID+         F   
Sbjct: 1679 EWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYN------VCFEKG 1732

Query: 1318 KRLVYIDRAPFVLTHDM 1334
            K L   ++ PF +T ++
Sbjct: 1733 KSLRVPEKVPFRMTQNI 1749



 Score = 39.1 bits (87), Expect = 0.12
 Identities = 23/93 (24%), Positives = 40/93 (43%), Gaps = 4/93 (4%)

Query: 1147 TYFSSNTLPLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLD----L 1202
            T   + T P K+ F+G+D    P +FK  +DL  D  ++Q + I++T++           
Sbjct: 1499 TILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRF 1558

Query: 1203 RMVTFQALPTSNSKGMIEIVTEAETLRAIQTEW 1235
                +   P     G+I+ V  A  L  +   W
Sbjct: 1559 HARHYSVTPLGTRSGLIQWVDGATPLFGLYKRW 1591


>AF395444-1|AAM73708.1| 3521|Homo sapiens PI-3-kinase ATX protein.
          Length = 3521

 Score = 40.7 bits (91), Expect = 0.039
 Identities = 23/77 (29%), Positives = 41/77 (53%), Gaps = 7/77 (9%)

Query: 1259 EYQRARDNFTASCAGYSVATYLLGICDRHNDNIML-KTSGHLFHIDFGKFLGDAQMFGNF 1317
            E+ R   ++  S A  S+  Y++G+ DRH DN+++  T+G + HID+         F   
Sbjct: 2169 EWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYN------VCFEKG 2222

Query: 1318 KRLVYIDRAPFVLTHDM 1334
            K L   ++ PF +T ++
Sbjct: 2223 KSLRVPEKVPFRMTQNI 2239



 Score = 39.1 bits (87), Expect = 0.12
 Identities = 23/93 (24%), Positives = 40/93 (43%), Gaps = 4/93 (4%)

Query: 1147 TYFSSNTLPLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLD----L 1202
            T   + T P K+ F+G+D    P +FK  +DL  D  ++Q + I++T++           
Sbjct: 1989 TILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRF 2048

Query: 1203 RMVTFQALPTSNSKGMIEIVTEAETLRAIQTEW 1235
                +   P     G+I+ V  A  L  +   W
Sbjct: 2049 HARHYSVTPLGTRSGLIQWVDGATPLFGLYKRW 2081


>AF186377-1|AAK58892.1| 2392|Homo sapiens LIP isoform of BLIP protein.
          Length = 2392

 Score = 40.7 bits (91), Expect = 0.039
 Identities = 23/77 (29%), Positives = 41/77 (53%), Gaps = 7/77 (9%)

Query: 1259 EYQRARDNFTASCAGYSVATYLLGICDRHNDNIML-KTSGHLFHIDFGKFLGDAQMFGNF 1317
            E+ R   ++  S A  S+  Y++G+ DRH DN+++  T+G + HID+         F   
Sbjct: 1040 EWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYN------VCFEKG 1093

Query: 1318 KRLVYIDRAPFVLTHDM 1334
            K L   ++ PF +T ++
Sbjct: 1094 KSLRVPEKVPFRMTQNI 1110



 Score = 39.1 bits (87), Expect = 0.12
 Identities = 23/93 (24%), Positives = 40/93 (43%), Gaps = 4/93 (4%)

Query: 1147 TYFSSNTLPLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLD----L 1202
            T   + T P K+ F+G+D    P +FK  +DL  D  ++Q + I++T++           
Sbjct: 860  TILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRF 919

Query: 1203 RMVTFQALPTSNSKGMIEIVTEAETLRAIQTEW 1235
                +   P     G+I+ V  A  L  +   W
Sbjct: 920  HARHYSVTPLGTRSGLIQWVDGATPLFGLYKRW 952


>AB061371-1|BAB70696.1| 3657|Homo sapiens phosphatidylinositol
            3-kinase-related protein kinase protein.
          Length = 3657

 Score = 40.7 bits (91), Expect = 0.039
 Identities = 23/77 (29%), Positives = 41/77 (53%), Gaps = 7/77 (9%)

Query: 1259 EYQRARDNFTASCAGYSVATYLLGICDRHNDNIML-KTSGHLFHIDFGKFLGDAQMFGNF 1317
            E+ R   ++  S A  S+  Y++G+ DRH DN+++  T+G + HID+         F   
Sbjct: 2305 EWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYN------VCFEKG 2358

Query: 1318 KRLVYIDRAPFVLTHDM 1334
            K L   ++ PF +T ++
Sbjct: 2359 KSLRVPEKVPFRMTQNI 2375



 Score = 39.1 bits (87), Expect = 0.12
 Identities = 23/93 (24%), Positives = 40/93 (43%), Gaps = 4/93 (4%)

Query: 1147 TYFSSNTLPLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLD----L 1202
            T   + T P K+ F+G+D    P +FK  +DL  D  ++Q + I++T++           
Sbjct: 2125 TILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRF 2184

Query: 1203 RMVTFQALPTSNSKGMIEIVTEAETLRAIQTEW 1235
                +   P     G+I+ V  A  L  +   W
Sbjct: 2185 HARHYSVTPLGTRSGLIQWVDGATPLFGLYKRW 2217


>AB007881-1|BAA24851.2| 1988|Homo sapiens KIAA0421 protein.
          Length = 1988

 Score = 40.7 bits (91), Expect = 0.039
 Identities = 23/77 (29%), Positives = 41/77 (53%), Gaps = 7/77 (9%)

Query: 1259 EYQRARDNFTASCAGYSVATYLLGICDRHNDNIML-KTSGHLFHIDFGKFLGDAQMFGNF 1317
            E+ R   ++  S A  S+  Y++G+ DRH DN+++  T+G + HID+         F   
Sbjct: 636  EWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYN------VCFEKG 689

Query: 1318 KRLVYIDRAPFVLTHDM 1334
            K L   ++ PF +T ++
Sbjct: 690  KSLRVPEKVPFRMTQNI 706



 Score = 39.1 bits (87), Expect = 0.12
 Identities = 23/93 (24%), Positives = 40/93 (43%), Gaps = 4/93 (4%)

Query: 1147 TYFSSNTLPLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLD----L 1202
            T   + T P K+ F+G+D    P +FK  +DL  D  ++Q + I++T++           
Sbjct: 456  TILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRF 515

Query: 1203 RMVTFQALPTSNSKGMIEIVTEAETLRAIQTEW 1235
                +   P     G+I+ V  A  L  +   W
Sbjct: 516  HARHYSVTPLGTRSGLIQWVDGATPLFGLYKRW 548


>U82828-2|AAB65827.1| 3056|Homo sapiens ATM protein.
          Length = 3056

 Score = 40.3 bits (90), Expect = 0.051
 Identities = 27/70 (38%), Positives = 36/70 (51%), Gaps = 7/70 (10%)

Query: 1267 FTASCAGYSVATYLLGICDRHNDNIML-KTSGHLFHIDFGKFLGDAQMFGNFKRLVYIDR 1325
            +T S A  S+  Y+LG+ DRH  NI++ + S  L HID G        F   K L   + 
Sbjct: 2852 YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG------VAFEQGKILPTPET 2905

Query: 1326 APFVLTHDMV 1335
             PF LT D+V
Sbjct: 2906 VPFRLTRDIV 2915



 Score = 38.7 bits (86), Expect = 0.16
 Identities = 25/75 (33%), Positives = 42/75 (56%), Gaps = 6/75 (8%)

Query: 1154 LPLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLR-----MVTFQ 1208
            LP  I+ +G+D      + K  DDLRQDA++ QV ++ +TL L+   + R     + T++
Sbjct: 2698 LPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTL-LQRNTETRKRKLTICTYK 2756

Query: 1209 ALPTSNSKGMIEIVT 1223
             +P S   G++E  T
Sbjct: 2757 VVPLSQRSGVLEWCT 2771


>U55757-2|AAB38310.1| 1708|Homo sapiens ataxia-telangiectasia mutated
            protein.
          Length = 1708

 Score = 40.3 bits (90), Expect = 0.051
 Identities = 27/70 (38%), Positives = 36/70 (51%), Gaps = 7/70 (10%)

Query: 1267 FTASCAGYSVATYLLGICDRHNDNIML-KTSGHLFHIDFGKFLGDAQMFGNFKRLVYIDR 1325
            +T S A  S+  Y+LG+ DRH  NI++ + S  L HID G        F   K L   + 
Sbjct: 1504 YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG------VAFEQGKILPTPET 1557

Query: 1326 APFVLTHDMV 1335
             PF LT D+V
Sbjct: 1558 VPFRLTRDIV 1567



 Score = 38.7 bits (86), Expect = 0.16
 Identities = 25/75 (33%), Positives = 42/75 (56%), Gaps = 6/75 (8%)

Query: 1154 LPLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLR-----MVTFQ 1208
            LP  I+ +G+D      + K  DDLRQDA++ QV ++ +TL L+   + R     + T++
Sbjct: 1350 LPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTL-LQRNTETRKRKLTICTYK 1408

Query: 1209 ALPTSNSKGMIEIVT 1223
             +P S   G++E  T
Sbjct: 1409 VVPLSQRSGVLEWCT 1423


>U55757-1|AAB38309.1| 3056|Homo sapiens ataxia-telangiectasia protein.
          Length = 3056

 Score = 40.3 bits (90), Expect = 0.051
 Identities = 27/70 (38%), Positives = 36/70 (51%), Gaps = 7/70 (10%)

Query: 1267 FTASCAGYSVATYLLGICDRHNDNIML-KTSGHLFHIDFGKFLGDAQMFGNFKRLVYIDR 1325
            +T S A  S+  Y+LG+ DRH  NI++ + S  L HID G        F   K L   + 
Sbjct: 2852 YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG------VAFEQGKILPTPET 2905

Query: 1326 APFVLTHDMV 1335
             PF LT D+V
Sbjct: 2906 VPFRLTRDIV 2915



 Score = 38.7 bits (86), Expect = 0.16
 Identities = 25/75 (33%), Positives = 42/75 (56%), Gaps = 6/75 (8%)

Query: 1154 LPLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLR-----MVTFQ 1208
            LP  I+ +G+D      + K  DDLRQDA++ QV ++ +TL L+   + R     + T++
Sbjct: 2698 LPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTL-LQRNTETRKRKLTICTYK 2756

Query: 1209 ALPTSNSKGMIEIVT 1223
             +P S   G++E  T
Sbjct: 2757 VVPLSQRSGVLEWCT 2771


>U47077-1|AAB39925.5| 4128|Homo sapiens DNA-dependent protein kinase
            catalytic subunit protein.
          Length = 4128

 Score = 40.3 bits (90), Expect = 0.051
 Identities = 35/139 (25%), Positives = 63/139 (45%), Gaps = 12/139 (8%)

Query: 1147 TYFSSNTLPLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLK----AGLDL 1202
            T  +S   P +I   G D    P + K G+DLRQD  V Q+ ++M+ +  +    +   L
Sbjct: 3727 TVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRAL 3786

Query: 1203 RMVTFQALPTSNSKGMIEIVTEAETLRAIQTEWGLTGSFKDKPIAEWLAKHNPSELEYQR 1262
            ++ T+  +P ++  G+IE +    TL+ +     L  +   +  A +L+       EY  
Sbjct: 3787 QLRTYSVVPMTSRLGLIEWLENTVTLKDL-----LLNTMSQEEKAAYLSDPRAPPCEY-- 3839

Query: 1263 ARDNFTASCAGYSVATYLL 1281
             +D  T     + V  Y+L
Sbjct: 3840 -KDWLTKMSGKHDVGAYML 3857



 Score = 37.5 bits (83), Expect = 0.36
 Identities = 20/52 (38%), Positives = 30/52 (57%), Gaps = 1/52 (1%)

Query: 1264 RDNFTASCAGYSVATYLLGICDRHNDNIML-KTSGHLFHIDFGKFLGDAQMF 1314
            R +F +S A   ++ ++LGI DRH +N M+   +G +  IDFG   G A  F
Sbjct: 3901 RSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQF 3952


>U33841-1|AAC50289.1| 3056|Homo sapiens ATM protein.
          Length = 3056

 Score = 40.3 bits (90), Expect = 0.051
 Identities = 27/70 (38%), Positives = 36/70 (51%), Gaps = 7/70 (10%)

Query: 1267 FTASCAGYSVATYLLGICDRHNDNIML-KTSGHLFHIDFGKFLGDAQMFGNFKRLVYIDR 1325
            +T S A  S+  Y+LG+ DRH  NI++ + S  L HID G        F   K L   + 
Sbjct: 2852 YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG------VAFEQGKILPTPET 2905

Query: 1326 APFVLTHDMV 1335
             PF LT D+V
Sbjct: 2906 VPFRLTRDIV 2915



 Score = 38.7 bits (86), Expect = 0.16
 Identities = 25/75 (33%), Positives = 42/75 (56%), Gaps = 6/75 (8%)

Query: 1154 LPLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLR-----MVTFQ 1208
            LP  I+ +G+D      + K  DDLRQDA++ QV ++ +TL L+   + R     + T++
Sbjct: 2698 LPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTL-LQRNTETRKRKLTICTYK 2756

Query: 1209 ALPTSNSKGMIEIVT 1223
             +P S   G++E  T
Sbjct: 2757 VVPLSQRSGVLEWCT 2771


>U26455-1|AAA86520.1| 1708|Homo sapiens phosphatidylinositol 3-kinase
            homolog protein.
          Length = 1708

 Score = 40.3 bits (90), Expect = 0.051
 Identities = 27/70 (38%), Positives = 36/70 (51%), Gaps = 7/70 (10%)

Query: 1267 FTASCAGYSVATYLLGICDRHNDNIML-KTSGHLFHIDFGKFLGDAQMFGNFKRLVYIDR 1325
            +T S A  S+  Y+LG+ DRH  NI++ + S  L HID G        F   K L   + 
Sbjct: 1504 YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG------VAFEQGKILPTPET 1557

Query: 1326 APFVLTHDMV 1335
             PF LT D+V
Sbjct: 1558 VPFRLTRDIV 1567



 Score = 38.7 bits (86), Expect = 0.16
 Identities = 25/75 (33%), Positives = 42/75 (56%), Gaps = 6/75 (8%)

Query: 1154 LPLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLR-----MVTFQ 1208
            LP  I+ +G+D      + K  DDLRQDA++ QV ++ +TL L+   + R     + T++
Sbjct: 1350 LPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTL-LQRNTETRKRKLTICTYK 1408

Query: 1209 ALPTSNSKGMIEIVT 1223
             +P S   G++E  T
Sbjct: 1409 VVPLSQRSGVLEWCT 1423


>AY316117-1|AAP69525.1| 4128|Homo sapiens protein kinase,
            DNA-activated, catalytic polypeptide protein.
          Length = 4128

 Score = 40.3 bits (90), Expect = 0.051
 Identities = 35/139 (25%), Positives = 63/139 (45%), Gaps = 12/139 (8%)

Query: 1147 TYFSSNTLPLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLK----AGLDL 1202
            T  +S   P +I   G D    P + K G+DLRQD  V Q+ ++M+ +  +    +   L
Sbjct: 3727 TVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRAL 3786

Query: 1203 RMVTFQALPTSNSKGMIEIVTEAETLRAIQTEWGLTGSFKDKPIAEWLAKHNPSELEYQR 1262
            ++ T+  +P ++  G+IE +    TL+ +     L  +   +  A +L+       EY  
Sbjct: 3787 QLRTYSVVPMTSRLGLIEWLENTVTLKDL-----LLNTMSQEEKAAYLSDPRAPPCEY-- 3839

Query: 1263 ARDNFTASCAGYSVATYLL 1281
             +D  T     + V  Y+L
Sbjct: 3840 -KDWLTKMSGKHDVGAYML 3857



 Score = 37.5 bits (83), Expect = 0.36
 Identities = 20/52 (38%), Positives = 30/52 (57%), Gaps = 1/52 (1%)

Query: 1264 RDNFTASCAGYSVATYLLGICDRHNDNIML-KTSGHLFHIDFGKFLGDAQMF 1314
            R +F +S A   ++ ++LGI DRH +N M+   +G +  IDFG   G A  F
Sbjct: 3901 RSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQF 3952


>AY030284-1|AAK40350.1|  879|Homo sapiens DNA-dependent protein kinase
            protein.
          Length = 879

 Score = 40.3 bits (90), Expect = 0.051
 Identities = 35/139 (25%), Positives = 63/139 (45%), Gaps = 12/139 (8%)

Query: 1147 TYFSSNTLPLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLK----AGLDL 1202
            T  +S   P +I   G D    P + K G+DLRQD  V Q+ ++M+ +  +    +   L
Sbjct: 478  TVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRAL 537

Query: 1203 RMVTFQALPTSNSKGMIEIVTEAETLRAIQTEWGLTGSFKDKPIAEWLAKHNPSELEYQR 1262
            ++ T+  +P ++  G+IE +    TL+ +     L  +   +  A +L+       EY  
Sbjct: 538  QLRTYSVVPMTSRLGLIEWLENTVTLKDL-----LLNTMSQEEKAAYLSDPRAPPCEY-- 590

Query: 1263 ARDNFTASCAGYSVATYLL 1281
             +D  T     + V  Y+L
Sbjct: 591  -KDWLTKMSGKHDVGAYML 608



 Score = 37.5 bits (83), Expect = 0.36
 Identities = 20/52 (38%), Positives = 30/52 (57%), Gaps = 1/52 (1%)

Query: 1264 RDNFTASCAGYSVATYLLGICDRHNDNIML-KTSGHLFHIDFGKFLGDAQMF 1314
            R +F +S A   ++ ++LGI DRH +N M+   +G +  IDFG   G A  F
Sbjct: 652  RSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQF 703


>AL359082-1|CAC42395.1|  895|Homo sapiens dJ576K7.1 (FK506 binding
            protein 12-rapamycin associated protein 1) protein.
          Length = 895

 Score = 40.3 bits (90), Expect = 0.051
 Identities = 25/91 (27%), Positives = 44/91 (48%), Gaps = 4/91 (4%)

Query: 1145 SCTYFSSNTLPLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLR- 1203
            S    +S   P K+  +G++      + K  +DLRQD  V+Q+  +++TL       LR 
Sbjct: 716  SLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRK 775

Query: 1204 ---MVTFQALPTSNSKGMIEIVTEAETLRAI 1231
               +  +  +P S + G+I  V   +TL A+
Sbjct: 776  NLSIQRYAVIPLSTNSGLIGWVPHCDTLHAL 806


>AL133355-2|CAI15352.1| 1133|Homo sapiens SH3 and PX domains 2A
            protein.
          Length = 1133

 Score = 39.1 bits (87), Expect = 0.12
 Identities = 17/47 (36%), Positives = 26/47 (55%), Gaps = 1/47 (2%)

Query: 1454 EKRYDPEKHYVYALRIYRLGQATPSVLYRSYKHFTELYQKICLHFPL 1500
            EKR +P KHYVY + +     +T   +YR Y  F +L  ++   FP+
Sbjct: 15   EKRRNPSKHYVYIINV-TWSDSTSQTIYRRYSKFFDLQMQLLDKFPI 60


>AL121929-5|CAI13962.1| 1133|Homo sapiens SH3 and PX domains 2A
            protein.
          Length = 1133

 Score = 39.1 bits (87), Expect = 0.12
 Identities = 17/47 (36%), Positives = 26/47 (55%), Gaps = 1/47 (2%)

Query: 1454 EKRYDPEKHYVYALRIYRLGQATPSVLYRSYKHFTELYQKICLHFPL 1500
            EKR +P KHYVY + +     +T   +YR Y  F +L  ++   FP+
Sbjct: 15   EKRRNPSKHYVYIINV-TWSDSTSQTIYRRYSKFFDLQMQLLDKFPI 60


>U34994-1|AAC50210.3| 4097|Homo sapiens DNA dependent protein kinase
            catalytic subunit protein.
          Length = 4097

 Score = 37.5 bits (83), Expect = 0.36
 Identities = 20/52 (38%), Positives = 30/52 (57%), Gaps = 1/52 (1%)

Query: 1264 RDNFTASCAGYSVATYLLGICDRHNDNIML-KTSGHLFHIDFGKFLGDAQMF 1314
            R +F +S A   ++ ++LGI DRH +N M+   +G +  IDFG   G A  F
Sbjct: 3870 RSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQF 3921


>AB208860-1|BAD92097.1|  726|Homo sapiens protein kinase,
            DNA-activated, catalytic polypeptide variant protein.
          Length = 726

 Score = 37.5 bits (83), Expect = 0.36
 Identities = 20/52 (38%), Positives = 30/52 (57%), Gaps = 1/52 (1%)

Query: 1264 RDNFTASCAGYSVATYLLGICDRHNDNIML-KTSGHLFHIDFGKFLGDAQMF 1314
            R +F +S A   ++ ++LGI DRH +N M+   +G +  IDFG   G A  F
Sbjct: 499  RSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQF 550


>U57835-1|AAB95193.1|  390|Homo sapiens p47-phox protein.
          Length = 390

 Score = 36.7 bits (81), Expect = 0.63
 Identities = 16/53 (30%), Positives = 30/53 (56%), Gaps = 1/53 (1%)

Query: 1448 VECLGYEKRYDPEKHYVYALRIYRLGQATPSVLYRSYKHFTELYQKICLHFPL 1500
            +  LG+EKR+ P +HYVY + + +    +  V+YR +    E ++ +   FP+
Sbjct: 9    IALLGFEKRFVPSQHYVY-MFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPI 60


>M55067-1|AAA59901.1|  390|Homo sapiens autosomal chronic
            granulomatous disease protein protein.
          Length = 390

 Score = 36.7 bits (81), Expect = 0.63
 Identities = 16/53 (30%), Positives = 30/53 (56%), Gaps = 1/53 (1%)

Query: 1448 VECLGYEKRYDPEKHYVYALRIYRLGQATPSVLYRSYKHFTELYQKICLHFPL 1500
            +  LG+EKR+ P +HYVY + + +    +  V+YR +    E ++ +   FP+
Sbjct: 9    IALLGFEKRFVPSQHYVY-MFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPI 60


>M25665-1|AAA57209.1|  390|Homo sapiens neutrophil cytosol factor 1
            protein.
          Length = 390

 Score = 36.7 bits (81), Expect = 0.63
 Identities = 16/53 (30%), Positives = 30/53 (56%), Gaps = 1/53 (1%)

Query: 1448 VECLGYEKRYDPEKHYVYALRIYRLGQATPSVLYRSYKHFTELYQKICLHFPL 1500
            +  LG+EKR+ P +HYVY + + +    +  V+YR +    E ++ +   FP+
Sbjct: 9    IALLGFEKRFVPSQHYVY-MFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPI 60


>BC065731-1|AAH65731.1|  390|Homo sapiens neutrophil cytosolic factor
            1, (chronic granulomatous disease, autosomal 1) protein.
          Length = 390

 Score = 36.7 bits (81), Expect = 0.63
 Identities = 16/53 (30%), Positives = 30/53 (56%), Gaps = 1/53 (1%)

Query: 1448 VECLGYEKRYDPEKHYVYALRIYRLGQATPSVLYRSYKHFTELYQKICLHFPL 1500
            +  LG+EKR+ P +HYVY + + +    +  V+YR +    E ++ +   FP+
Sbjct: 9    IALLGFEKRFVPSQHYVY-MFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPI 60


>BC002816-1|AAH02816.1|  390|Homo sapiens neutrophil cytosolic factor
            1, (chronic granulomatous disease, autosomal 1) protein.
          Length = 390

 Score = 36.7 bits (81), Expect = 0.63
 Identities = 16/53 (30%), Positives = 30/53 (56%), Gaps = 1/53 (1%)

Query: 1448 VECLGYEKRYDPEKHYVYALRIYRLGQATPSVLYRSYKHFTELYQKICLHFPL 1500
            +  LG+EKR+ P +HYVY + + +    +  V+YR +    E ++ +   FP+
Sbjct: 9    IALLGFEKRFVPSQHYVY-MFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPI 60


>AK223217-1|BAD96937.1|  390|Homo sapiens neutrophil cytosolic factor
            1 variant protein.
          Length = 390

 Score = 36.7 bits (81), Expect = 0.63
 Identities = 16/53 (30%), Positives = 30/53 (56%), Gaps = 1/53 (1%)

Query: 1448 VECLGYEKRYDPEKHYVYALRIYRLGQATPSVLYRSYKHFTELYQKICLHFPL 1500
            +  LG+EKR+ P +HYVY + + +    +  V+YR +    E ++ +   FP+
Sbjct: 9    IALLGFEKRFVPSQHYVY-MFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPI 60


>AF330627-1|AAK19518.1|  390|Homo sapiens adaptor protein p47phox
            protein.
          Length = 390

 Score = 36.7 bits (81), Expect = 0.63
 Identities = 16/53 (30%), Positives = 30/53 (56%), Gaps = 1/53 (1%)

Query: 1448 VECLGYEKRYDPEKHYVYALRIYRLGQATPSVLYRSYKHFTELYQKICLHFPL 1500
            +  LG+EKR+ P +HYVY + + +    +  V+YR +    E ++ +   FP+
Sbjct: 9    IALLGFEKRFVPSQHYVY-MFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPI 60


>AF184614-1|AAF34737.1|  390|Homo sapiens p47-phox protein.
          Length = 390

 Score = 36.7 bits (81), Expect = 0.63
 Identities = 16/53 (30%), Positives = 30/53 (56%), Gaps = 1/53 (1%)

Query: 1448 VECLGYEKRYDPEKHYVYALRIYRLGQATPSVLYRSYKHFTELYQKICLHFPL 1500
            +  LG+EKR+ P +HYVY + + +    +  V+YR +    E ++ +   FP+
Sbjct: 9    IALLGFEKRFVPSQHYVY-MFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPI 60


>AC083884-6|AAS07465.1|  390|Homo sapiens unknown protein.
          Length = 390

 Score = 36.7 bits (81), Expect = 0.63
 Identities = 16/53 (30%), Positives = 30/53 (56%), Gaps = 1/53 (1%)

Query: 1448 VECLGYEKRYDPEKHYVYALRIYRLGQATPSVLYRSYKHFTELYQKICLHFPL 1500
            +  LG+EKR+ P +HYVY + + +    +  V+YR +    E ++ +   FP+
Sbjct: 9    IALLGFEKRFVPSQHYVY-MFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPI 60


>AY220758-1|AAO26044.1| 2756|Homo sapiens ataxia telangiectasia
            mutated (includes complementation groups A, C and D)
            protein.
          Length = 2756

 Score = 33.5 bits (73), Expect = 5.9
 Identities = 17/41 (41%), Positives = 26/41 (63%)

Query: 1154 LPLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTL 1194
            LP  I+ +G+D      + K  DDLRQDA++ QV ++ +TL
Sbjct: 2698 LPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTL 2738


  Database: human
    Posted date:  Oct 5, 2007 11:13 AM
  Number of letters in database: 73,234,838
  Number of sequences in database:  224,733
  
Lambda     K      H
   0.319    0.134    0.401 

Gapped
Lambda     K      H
   0.279   0.0580    0.190 


Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 199,224,396
Number of Sequences: 224733
Number of extensions: 7748104
Number of successful extensions: 17574
Number of sequences better than 10.0: 100
Number of HSP's better than 10.0 without gapping: 81
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 17131
Number of HSP's gapped (non-prelim): 266
length of query: 1505
length of database: 73,234,838
effective HSP length: 100
effective length of query: 1405
effective length of database: 50,761,538
effective search space: 71319960890
effective search space used: 71319960890
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
S2: 72 (33.1 bits)