Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001256-TA|BGIBMGA001256-PA|IPR002172|Low density
lipoprotein-receptor, class A, IPR000152|Aspartic acid and asparagine
hydroxylation site, IPR013032|EGF-like region, IPR001881|EGF-like
calcium-binding, IPR000033|Low-density lipoprotein receptor, YWTD
repeat, IPR006210|EGF, IPR013091|EGF calcium-binding,
IPR006209|EGF-like
(1776 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
AB084910-1|BAD83615.1| 1905|Homo sapiens low density lipoprotein... 1179 0.0
AB231861-1|BAE19679.1| 1950|Homo sapiens low-density lipoprotein... 1167 0.0
AB011540-1|BAA32468.1| 1576|Homo sapiens MEGF7 protein. 1085 0.0
AF283321-1|AAK52433.1| 1611|Homo sapiens low density lipoprotein... 780 0.0
AF077820-1|AAC72791.1| 1615|Homo sapiens LDL receptor member LR3... 780 0.0
AF064548-1|AAC36467.1| 1615|Homo sapiens low-density lipoprotein... 780 0.0
AB017498-1|BAA33051.1| 1615|Homo sapiens Lipoprotein Receptor Re... 780 0.0
BC126405-1|AAI26406.1| 1613|Homo sapiens low density lipoprotein... 776 0.0
BC117136-1|AAI17137.1| 1613|Homo sapiens low density lipoprotein... 776 0.0
AF074264-1|AAC33006.1| 1613|Homo sapiens LDL receptor-related pr... 776 0.0
AB209683-1|BAD92920.1| 1477|Homo sapiens low density lipoprotein... 705 0.0
U33837-1|AAB41649.1| 4655|Homo sapiens gp330 precursor protein. 603 e-171
AY265358-1|AAP88586.1| 4655|Homo sapiens glycoprotein receptor g... 603 e-171
AY265357-1|AAP88585.1| 4655|Homo sapiens glycoprotein receptor g... 603 e-171
AC007556-2|AAX88965.1| 3881|Homo sapiens unknown protein. 603 e-171
X13916-1|CAA32112.1| 4544|Homo sapiens LDL-receptor related prec... 549 e-155
DQ314873-1|ABC40732.1| 4544|Homo sapiens low density lipoprotein... 549 e-155
AF058427-1|AAC64265.1| 4544|Homo sapiens lipoprotein receptor-re... 549 e-155
AF176832-1|AAF70379.1| 4599|Homo sapiens low density lipoprotein... 524 e-147
AF283374-1|AAL38108.1| 1731|Homo sapiens candidate tumor suppres... 519 e-146
AC010740-1|AAY14689.1| 862|Homo sapiens unknown protein. 417 e-115
AB209498-1|BAD92735.1| 2359|Homo sapiens low density lipoprotein... 406 e-112
AK054663-1|BAB70786.1| 820|Homo sapiens umor (LRPDIT) mRNA. pr... 391 e-107
AL606760-3|CAI18909.1| 700|Homo sapiens low density lipoprotein... 383 e-105
AL355483-3|CAI22782.1| 700|Homo sapiens low density lipoprotein... 383 e-105
S73849-1|AAB31735.1| 873|Homo sapiens very low density lipoprot... 381 e-104
L22431-1|AAA61344.1| 873|Homo sapiens very low density lipoprot... 381 e-104
D16532-1|BAA03969.1| 873|Homo sapiens very low density lipoprot... 381 e-104
D16494-1|BAA03946.1| 845|Homo sapiens very low density lipoprot... 381 e-104
D16493-1|BAA03945.1| 873|Homo sapiens very low density lipoprot... 381 e-104
DQ067198-1|AAY46157.1| 873|Homo sapiens very low density lipopr... 381 e-104
AL450467-4|CAH72455.1| 845|Homo sapiens very low density lipopr... 381 e-104
AL450467-3|CAH72454.1| 873|Homo sapiens very low density lipopr... 381 e-104
L20470-1|AAA53684.1| 873|Homo sapiens very low density lipoprot... 376 e-103
AL450467-2|CAH72453.1| 752|Homo sapiens very low density lipopr... 375 e-103
AK092381-1|BAC03874.1| 752|Homo sapiens protein ( Homo sapiens ... 375 e-103
Z75190-1|CAA99509.1| 699|Homo sapiens apolipoprotein E receptor... 369 e-101
U04441-1|AAB02882.1| 1751|Homo sapiens glycoprotein 330 protein. 367 e-100
D86407-1|BAA21824.1| 963|Homo sapiens ApoER2 protein. 366 e-100
D50678-1|BAA09328.1| 963|Homo sapiens apolipoprotein E receptor... 366 e-100
BC051836-1|AAH51836.2| 904|Homo sapiens low density lipoprotein... 365 1e-99
AL606760-4|CAI18908.1| 963|Homo sapiens low density lipoprotein... 365 1e-99
AL606760-2|CAI18910.1| 904|Homo sapiens low density lipoprotein... 365 1e-99
AL355483-2|CAI22780.1| 904|Homo sapiens low density lipoprotein... 365 1e-99
AL355483-1|CAI22781.1| 963|Homo sapiens low density lipoprotein... 365 1e-99
D86407-2|BAA21825.1| 793|Homo sapiens ApoER2delta4-7 protein. 347 2e-94
L00352-1|AAA56833.1| 860|Homo sapiens low density lipoprotein r... 342 6e-93
BT007361-1|AAP36025.1| 860|Homo sapiens low density lipoprotein... 342 6e-93
BC014514-1|AAH14514.1| 860|Homo sapiens low density lipoprotein... 342 6e-93
AY324609-1|AAP72971.1| 860|Homo sapiens low density lipoprotein... 342 6e-93
AY114155-1|AAM56036.1| 860|Homo sapiens low density lipoprotein... 342 6e-93
AF217403-1|AAF24515.1| 837|Homo sapiens low density lipoprotein... 342 6e-93
AB209409-1|BAD92646.1| 870|Homo sapiens low density lipoprotein... 342 6e-93
AF283408-1|AAL38109.1| 1537|Homo sapiens candidate tumor suppres... 327 2e-88
AC008178-1|AAY24266.1| 773|Homo sapiens unknown protein. 313 4e-84
AF283342-1|AAL38107.1| 881|Homo sapiens candidate tumor suppres... 304 2e-81
AC073319-1|AAX93075.1| 585|Homo sapiens unknown protein. 276 5e-73
AC093039-1|AAX88911.1| 425|Homo sapiens unknown protein. 239 5e-62
AB209707-1|BAD92944.1| 1720|Homo sapiens low density lipoprotein... 232 1e-59
X04571-1|CAA28240.1| 1207|Homo sapiens protein ( Human mRNA for ... 229 5e-59
BC113461-1|AAI13462.1| 1207|Homo sapiens epidermal growth factor... 229 5e-59
BC093731-1|AAH93731.1| 1207|Homo sapiens epidermal growth factor... 229 5e-59
AY506357-1|AAR84237.1| 1152|Homo sapiens truncated epidermal gro... 229 5e-59
BC021204-1|AAH21204.1| 439|Homo sapiens LRP1 protein protein. 225 1e-57
AB208822-1|BAD92059.1| 555|Homo sapiens Very low-density lipopr... 219 1e-55
AC068195-1|AAX93243.1| 1126|Homo sapiens unknown protein. 214 3e-54
AC117947-1|AAX88968.1| 346|Homo sapiens unknown protein. 199 6e-50
M27445-1|AAA57261.1| 581|Homo sapiens nidogen protein. 184 3e-45
BC045606-1|AAH45606.1| 1114|Homo sapiens NID1 protein protein. 184 3e-45
AL139161-2|CAI23422.1| 1247|Homo sapiens nidogen 1 protein. 184 3e-45
AL139161-1|CAI23421.1| 1114|Homo sapiens nidogen 1 protein. 184 3e-45
AL122018-2|CAI22681.1| 1247|Homo sapiens nidogen 1 protein. 184 3e-45
AL122018-1|CAI22680.1| 1114|Homo sapiens nidogen 1 protein. 184 3e-45
Y08110-1|CAA69325.1| 2214|Homo sapiens mosaic protein LR11 protein. 181 2e-44
X82245-1|CAA57709.1| 1246|Homo sapiens nidogen protein. 181 2e-44
U60975-1|AAC50891.2| 2214|Homo sapiens gp250 precursor protein. 181 2e-44
M30269-1|AAA59932.1| 1247|Homo sapiens nidogen protein. 181 2e-44
X55077-1|CAA38905.1| 591|Homo sapiens alpha-2 macroglobulin rec... 173 4e-42
AB209448-1|BAD92685.1| 1241|Homo sapiens nidogen (enactin) varia... 173 5e-42
BC139736-1|AAI39737.1| 224|Homo sapiens LRP5L protein protein. 172 8e-42
S73145-1|AAB30825.1| 268|Homo sapiens calcium sensor protein pr... 171 3e-41
D86425-1|BAA13087.1| 1376|Homo sapiens osteonidogen protein. 164 2e-39
BC035608-1|AAH35608.1| 969|Homo sapiens NID2 protein protein. 164 2e-39
AJ223500-1|CAA11418.1| 1375|Homo sapiens nidogen-2 protein. 164 2e-39
AB009799-1|BAA24112.1| 1376|Homo sapiens osteonidogen protein. 164 2e-39
BC072015-1|AAH72015.1| 296|Homo sapiens LRP1 protein protein. 151 2e-35
BC052593-1|AAH52593.1| 296|Homo sapiens LRP1 protein protein. 151 2e-35
BC045107-1|AAH45107.1| 292|Homo sapiens LRP1 protein protein. 151 2e-35
AL450467-1|CAH72452.1| 173|Homo sapiens very low density lipopr... 133 6e-30
AF117899-1|AAF27280.1| 363|Homo sapiens LDLR-FUT fusion protein... 130 3e-29
X62515-1|CAA44373.1| 4393|Homo sapiens Human basement membrane h... 127 4e-28
M85289-1|AAA52700.1| 4391|Homo sapiens heparan sulfate proteogly... 127 4e-28
AL590556-2|CAH71870.1| 4391|Homo sapiens heparan sulfate proteog... 127 4e-28
AL590103-2|CAI12125.1| 4391|Homo sapiens heparan sulfate proteog... 127 4e-28
AL445795-1|CAC18534.1| 4370|Homo sapiens heparan sulfate proteog... 127 4e-28
AC108036-1|AAX93208.1| 449|Homo sapiens unknown protein. 127 4e-28
BC110451-1|AAI10452.1| 1042|Homo sapiens corin, serine peptidase... 122 1e-26
AF133845-1|AAD31850.1| 1042|Homo sapiens corin protein. 122 1e-26
AC068287-1|AAY24318.1| 223|Homo sapiens unknown protein. 114 3e-24
BC042754-1|AAH42754.2| 345|Homo sapiens low density lipoprotein... 111 3e-23
AK075546-1|BAC11689.1| 345|Homo sapiens protein ( Homo sapiens ... 111 3e-23
BC030532-1|AAH30532.1| 855|Homo sapiens suppression of tumorige... 107 3e-22
BC018146-1|AAH18146.1| 422|Homo sapiens ST14 protein protein. 107 3e-22
BC005826-1|AAH05826.2| 526|Homo sapiens ST14 protein protein. 107 3e-22
AF283256-1|AAG13949.1| 325|Homo sapiens serine protease SNC19 p... 107 3e-22
AF133086-1|AAF00109.1| 855|Homo sapiens membrane-type serine pr... 107 3e-22
AF118224-1|AAD42765.2| 855|Homo sapiens matriptase protein. 107 3e-22
AF057145-1|AAG15395.1| 855|Homo sapiens serine protease TADG15 ... 107 3e-22
AB030036-1|BAB20376.1| 855|Homo sapiens prostamin protein. 107 3e-22
AL590103-10|CAI12134.1| 179|Homo sapiens heparan sulfate proteo... 102 1e-20
AB111888-1|BAC98376.1| 1322|Homo sapiens KIAA2036 protein protein. 94 5e-18
BC113716-1|AAI13717.1| 713|Homo sapiens low density lipoprotein... 90 8e-17
BC113714-1|AAI13715.1| 713|Homo sapiens low density lipoprotein... 90 8e-17
BC064901-1|AAH64901.1| 457|Homo sapiens LRP10 protein protein. 90 8e-17
AY358399-1|AAQ88765.1| 713|Homo sapiens LRP10 protein. 90 8e-17
BC088378-1|AAH88378.1| 377|Homo sapiens LRP10 protein protein. 88 3e-16
U94333-1|AAB53110.1| 652|Homo sapiens C1qR(p) protein. 86 1e-15
BC117322-1|AAI17323.1| 572|Homo sapiens TMPRSS7 protein protein. 86 1e-15
BC028075-1|AAH28075.1| 652|Homo sapiens CD93 molecule protein. 86 1e-15
AL118508-1|CAC00597.1| 652|Homo sapiens complement component 1,... 86 1e-15
AK131211-1|BAD18401.1| 572|Homo sapiens protein ( Homo sapiens ... 86 1e-15
AJ295142-1|CAC82720.1| 652|Homo sapiens C1q receptor protein pr... 86 1e-15
AB209895-1|BAD93132.1| 671|Homo sapiens complement component 1,... 86 1e-15
BC111690-1|AAI11691.1| 807|Homo sapiens SCUBE2 protein protein. 85 2e-15
AK131552-1|BAD18686.1| 682|Homo sapiens protein ( Homo sapiens ... 85 2e-15
AK123039-1|BAC85521.1| 971|Homo sapiens protein ( Homo sapiens ... 85 2e-15
AJ400877-1|CAB92285.1| 999|Homo sapiens CEGP1 protein protein. 85 2e-15
BC032109-1|AAH32109.1| 859|Homo sapiens low density lipoprotein... 84 5e-15
AF166350-1|AAD44360.1| 859|Homo sapiens ST7 protein protein. 84 5e-15
AB208957-1|BAD92194.1| 793|Homo sapiens suppression of tumorige... 84 5e-15
AY358895-1|AAQ89254.1| 915|Homo sapiens MATN2 protein. 82 2e-14
AY358898-1|AAQ89257.1| 448|Homo sapiens FBLN5 protein. 81 3e-14
AF525689-1|AAN77133.1| 988|Homo sapiens signal peptide-CUB-EGF-... 81 3e-14
CR457140-1|CAG33421.1| 448|Homo sapiens FBLN5 protein. 81 4e-14
BC052263-1|AAH52263.2| 992|Homo sapiens signal peptide, CUB dom... 81 4e-14
BC022280-1|AAH22280.1| 448|Homo sapiens fibulin 5 protein. 81 4e-14
AJ133490-1|CAB38568.1| 448|Homo sapiens fibulin-5 protein. 81 4e-14
AF112152-1|AAD41768.1| 448|Homo sapiens developmental arteries ... 81 4e-14
BC127263-1|AAI27264.1| 363|Homo sapiens SCUBE1 protein protein. 81 5e-14
BC007408-1|AAH07408.1| 770|Homo sapiens low density lipoprotein... 80 6e-14
AB009462-1|BAA32330.1| 770|Homo sapiens LDL receptor related pr... 80 6e-14
Z99756-1|CAI18854.1| 988|Homo sapiens protein ( Human DNA seque... 80 8e-14
Z82214-3|CAI21674.1| 988|Homo sapiens protein ( Human DNA seque... 80 8e-14
Z97832-1|CAI20187.1| 993|Homo sapiens protein ( Human DNA seque... 79 1e-13
AY639608-1|AAU08347.1| 993|Homo sapiens signal peptide, CUB and... 79 1e-13
AK126750-1|BAC86671.1| 644|Homo sapiens protein ( Homo sapiens ... 79 1e-13
AF452494-1|AAN76808.1| 993|Homo sapiens CUB and EGF containing ... 79 1e-13
AF093118-1|AAC62107.1| 448|Homo sapiens UP50 protein. 79 1e-13
X63556-1|CAA45118.1| 3002|Homo sapiens fibrillin protein. 78 3e-13
X62008-1|CAB56534.1| 517|Homo sapiens fibrillin 15 protein. 78 3e-13
L13923-1|AAB02036.1| 2871|Homo sapiens fibrillin protein. 78 3e-13
AB177803-1|BAD16739.1| 2871|Homo sapiens fibrillin 1 protein. 78 3e-13
AB177802-1|BAD16738.1| 1365|Homo sapiens fibrillin 1 protein. 78 3e-13
U69263-1|AAC51260.2| 956|Homo sapiens matrilin-2 precursor prot... 77 4e-13
AK075489-1|BAC11648.1| 451|Homo sapiens rase 7. protein. 77 4e-13
X82494-1|CAA57876.1| 1184|Homo sapiens fibulin-2 protein. 77 8e-13
BC051690-1|AAH51690.1| 1184|Homo sapiens fibulin 2 protein. 77 8e-13
AY130459-1|AAN05436.1| 1231|Homo sapiens fibulin 2 protein. 77 8e-13
AY130458-1|AAN05435.1| 1231|Homo sapiens fibulin 2 protein. 77 8e-13
Z98047-1|CAI19628.1| 703|Homo sapiens fibulin 1 protein. 76 1e-12
Z95331-3|CAI41717.1| 703|Homo sapiens fibulin 1 protein. 76 1e-12
X53743-1|CAA37772.1| 683|Homo sapiens fibulin-1 C protein. 76 1e-12
X53742-1|CAA37771.1| 601|Homo sapiens fibulin-1 B protein. 76 1e-12
X53741-1|CAA37770.1| 566|Homo sapiens fibulin-1 A protein. 76 1e-12
U01244-1|AAB17099.1| 703|Homo sapiens fibulin-1D protein. 76 1e-12
BC022497-1|AAH22497.1| 683|Homo sapiens fibulin 1 protein. 76 1e-12
BC016394-1|AAH16394.1| 715|Homo sapiens MATN2 protein protein. 76 1e-12
BC010444-1|AAH10444.1| 937|Homo sapiens matrilin 2 protein. 76 1e-12
AL833931-1|CAD38787.1| 1016|Homo sapiens hypothetical protein pr... 76 1e-12
AL021391-3|CAI18930.1| 703|Homo sapiens fibulin 1 protein. 76 1e-12
AK075566-1|BAC11705.1| 638|Homo sapiens protein ( Homo sapiens ... 76 1e-12
AF217999-1|AAG17241.1| 495|Homo sapiens unknown protein. 76 1e-12
AF126110-1|AAK37822.1| 703|Homo sapiens fibulin-1 isoform D pre... 76 1e-12
AL513320-1|CAI14334.1| 1229|Homo sapiens multiple EGF-like-domai... 75 2e-12
AL512413-3|CAH70834.1| 1229|Homo sapiens multiple EGF-like-domai... 75 2e-12
AB231860-1|BAE19678.1| 1640|Homo sapiens hypothetical protein pr... 75 2e-12
AB011539-1|BAA32467.2| 1246|Homo sapiens MEGF6 protein. 75 2e-12
AB208840-1|BAD92077.1| 830|Homo sapiens fibrillin 1 variant pro... 75 2e-12
Y13341-1|CAA73785.1| 310|Homo sapiens matrilin-3 precursor prot... 75 3e-12
BC139907-1|AAI39908.1| 486|Homo sapiens matrilin 3 protein. 75 3e-12
AJ224741-1|CAA12110.1| 486|Homo sapiens matrilin-3 protein. 75 3e-12
AJ001047-1|CAA04501.1| 303|Homo sapiens Matrilin-3 protein. 75 3e-12
AC079145-2|AAX88937.1| 486|Homo sapiens unknown protein. 75 3e-12
AK092062-1|BAC03798.1| 880|Homo sapiens protein ( Homo sapiens ... 74 4e-12
X62009-1|CAB56757.1| 754|Homo sapiens fibrillin 5 protein. 74 5e-12
U03877-1|AAA65590.1| 387|Homo sapiens extracellular protein pro... 74 5e-12
CR456446-1|CAG30332.1| 824|Homo sapiens dJ1170K4.2 protein. 74 5e-12
BC098561-1|AAH98561.1| 493|Homo sapiens EGF-containing fibulin-... 74 5e-12
BC014410-1|AAH14410.1| 493|Homo sapiens EGF-containing fibulin-... 74 5e-12
AY358398-1|AAQ88764.1| 802|Homo sapiens PVAE354 protein. 74 5e-12
AY055384-1|AAL16414.1| 811|Homo sapiens type II transmembrane s... 74 5e-12
AY055383-1|AAL16413.1| 811|Homo sapiens type II transmembrane s... 74 5e-12
AY004330-1|AAK11491.1| 493|Homo sapiens EGF-containing fibulin-... 74 5e-12
AL022314-2|CAI19335.1| 788|Homo sapiens protein ( Human DNA seq... 74 5e-12
AK129963-1|BAC85262.1| 284|Homo sapiens protein ( Homo sapiens ... 74 5e-12
AJ319876-1|CAC85953.1| 802|Homo sapiens matriptase-2 protein. 74 5e-12
AB209212-1|BAD92449.1| 418|Homo sapiens EGF-containing fibulin-... 74 5e-12
U03272-1|AAA18950.1| 2911|Homo sapiens fibrillin-2 protein. 72 2e-11
AB209735-1|BAD92972.1| 1976|Homo sapiens fibrillin 2 (congenital... 72 2e-11
AC010895-1|AAY14669.1| 320|Homo sapiens unknown protein. 72 2e-11
AK056571-1|BAB71219.1| 955|Homo sapiens protein ( Homo sapiens ... 71 3e-11
AF093119-1|AAC62108.1| 439|Homo sapiens UPH1 protein. 71 4e-11
BC077719-1|AAH77719.1| 219|Homo sapiens VWCE protein protein. 71 5e-11
BC052564-1|AAH52564.1| 219|Homo sapiens VWCE protein protein. 71 5e-11
BC042143-1|AAH42143.1| 237|Homo sapiens VWCE protein protein. 71 5e-11
Z37976-1|CAA86030.1| 1821|Homo sapiens LTBP-2 precursor protein. 70 9e-11
Y00318-2|CAA68417.1| 321|Homo sapiens protein ( Human mRNA for ... 70 9e-11
Y00318-1|CAA68416.1| 565|Homo sapiens protein ( Human mRNA for ... 70 9e-11
X05495-1|CAA29045.1| 575|Homo sapiens thrombomodulin protein. 70 9e-11
S82451-1|AAB37459.1| 1821|Homo sapiens latent transforming growt... 70 9e-11
M16552-1|AAB59508.1| 575|Homo sapiens THBD protein. 70 9e-11
J02973-1|AAA61175.1| 575|Homo sapiens THBD protein. 70 9e-11
J02770-1|AAA52455.1| 583|Homo sapiens IF protein. 70 9e-11
D00210-1|BAA00149.1| 575|Homo sapiens thrombomodulin precursor ... 70 9e-11
CR457174-1|CAG33455.1| 282|Homo sapiens 8D6A protein. 70 9e-11
BC078659-1|AAH78659.1| 1821|Homo sapiens latent transforming gro... 70 9e-11
BC053357-1|AAH53357.1| 575|Homo sapiens thrombomodulin protein. 70 9e-11
BC035602-1|AAH35602.2| 575|Homo sapiens thrombomodulin protein. 70 9e-11
BC020718-1|AAH20718.1| 377|Homo sapiens CFI protein protein. 70 9e-11
BC007083-1|AAH07083.1| 282|Homo sapiens CD320 molecule protein. 70 9e-11
BC000668-1|AAH00668.1| 282|Homo sapiens CD320 molecule protein. 70 9e-11
AY358420-1|AAQ88786.1| 282|Homo sapiens SGGW198 protein. 70 9e-11
AL365455-1|CAB97010.1| 282|Homo sapiens 8D6 antigen protein. 70 9e-11
AL049651-2|CAB51954.1| 575|Homo sapiens thrombomodulin protein. 70 9e-11
AK222623-1|BAD96343.1| 282|Homo sapiens 8D6 antigen variant pro... 70 9e-11
AF495471-1|AAM03232.1| 575|Homo sapiens thrombomodulin protein. 70 9e-11
AF161254-1|AAF61850.1| 282|Homo sapiens 8D6 antigen protein. 70 9e-11
AB209865-1|BAD93102.1| 1700|Homo sapiens latent transforming gro... 70 9e-11
M34057-1|AAA61160.1| 1394|Homo sapiens TGFB1 protein. 69 1e-10
BC130289-1|AAI30290.1| 1395|Homo sapiens latent transforming gro... 69 1e-10
AF489528-1|AAM03124.1| 1394|Homo sapiens transforming growth fac... 69 1e-10
AC019127-1|AAY24260.1| 697|Homo sapiens unknown protein. 69 1e-10
AB208801-1|BAD92038.1| 1348|Homo sapiens latent transforming gro... 69 1e-10
AY165865-1|AAO18147.1| 2809|Homo sapiens fibrillin-3 short form ... 69 2e-10
AY165864-1|AAO18146.1| 2809|Homo sapiens fibrillin-3 short form ... 69 2e-10
AY165863-1|AAO18145.1| 2809|Homo sapiens fibrillin-3 short form ... 69 2e-10
AB177799-1|BAD16735.1| 2809|Homo sapiens fibrillin 3 protein. 69 2e-10
AB177798-1|BAD16734.1| 2809|Homo sapiens fibrillin 3 protein. 69 2e-10
AB177797-1|BAD16733.1| 2809|Homo sapiens fibrillin 3 protein. 69 2e-10
AB053450-1|BAB47408.2| 2816|Homo sapiens fibrillin3 protein. 69 2e-10
AK027775-1|BAB55358.1| 537|Homo sapiens protein ( Homo sapiens ... 68 3e-10
AF054502-1|AAC39882.1| 669|Homo sapiens latent transforming gro... 68 3e-10
AK074499-1|BAC11024.1| 636|Homo sapiens protein ( Homo sapiens ... 68 4e-10
CR541934-1|CAG46732.1| 443|Homo sapiens EFEMP2 protein. 67 5e-10
BC010456-1|AAH10456.1| 443|Homo sapiens EGF-containing fibulin-... 67 5e-10
AY358899-1|AAQ89258.1| 443|Homo sapiens EFEMP2 protein. 67 5e-10
AJ132819-1|CAA10791.2| 443|Homo sapiens fibulin-4 protein. 67 5e-10
AF109121-1|AAF65188.1| 443|Homo sapiens EGF-containing fibulin-... 67 5e-10
AB177800-1|BAD16736.1| 2809|Homo sapiens fibrillin 3 protein. 67 5e-10
AB030655-1|BAA92880.1| 443|Homo sapiens mutant p53 binding prot... 67 5e-10
Y13622-1|CAA73944.1| 1587|Homo sapiens latent TGF-beta binding p... 66 1e-09
AF051345-1|AAC39880.2| 1624|Homo sapiens latent transforming gro... 66 1e-09
AF051344-1|AAC39879.2| 1557|Homo sapiens latent transforming gro... 66 1e-09
AC110087-1|AAY24167.1| 132|Homo sapiens unknown protein. 66 1e-09
X81479-1|CAA57232.1| 886|Homo sapiens EMR1 protein. 65 2e-09
BC131763-1|AAI31764.1| 581|Homo sapiens matrilin 4 protein. 65 2e-09
BC008761-1|AAH08761.2| 743|Homo sapiens LTBP3 protein protein. 65 2e-09
AL021578-3|CAB39280.1| 581|Homo sapiens matrilin 4 protein. 65 2e-09
AK024477-1|BAB15767.1| 1382|Homo sapiens FLJ00070 protein protein. 65 2e-09
AJ007581-1|CAA07569.1| 581|Homo sapiens matrilin-4 protein. 65 2e-09
AF135960-1|AAF62352.3| 1256|Homo sapiens latent transforming gro... 65 2e-09
AL021578-2|CAI21077.1| 432|Homo sapiens matrilin 4 protein. 65 2e-09
AL021578-1|CAB46380.1| 622|Homo sapiens matrilin 4 protein. 65 2e-09
AK131282-1|BAD18457.1| 872|Homo sapiens protein ( Homo sapiens ... 65 2e-09
AF124486-1|AAG45245.1| 443|Homo sapiens fibulin-like extracellu... 64 3e-09
BC047916-1|AAH47916.1| 347|Homo sapiens SCUBE1 protein protein. 64 4e-09
BC038587-1|AAH38587.1| 553|Homo sapiens EGF-like-domain, multip... 64 4e-09
AY358347-1|AAQ88713.1| 406|Homo sapiens VPPP1921 protein. 64 4e-09
AY358333-1|AAQ88699.1| 338|Homo sapiens EGFL6 protein. 64 4e-09
AK075214-1|BAC11477.1| 553|Homo sapiens protein ( Homo sapiens ... 64 4e-09
AJ245671-1|CAB92132.1| 554|Homo sapiens hypothetical protein pr... 64 4e-09
AF186084-1|AAF27812.1| 553|Homo sapiens epidermal growth factor... 64 4e-09
AB075863-1|BAB85569.1| 418|Homo sapiens KIAA1983 protein protein. 64 4e-09
X12892-1|CAA31383.1| 650|Homo sapiens protein ( H.sapiens mRNA ... 63 1e-08
M14338-1|AAA60181.1| 650|Homo sapiens protein S precursor protein. 63 1e-08
BX928748-1|CAH74051.1| 5635|Homo sapiens protein ( Human DNA seq... 62 2e-08
BC105633-1|AAI05634.1| 757|Homo sapiens tumor endothelial marke... 62 2e-08
BC104484-1|AAI04485.1| 757|Homo sapiens tumor endothelial marke... 62 2e-08
BC071562-1|AAH71562.2| 1235|Homo sapiens NOTCH2 protein protein. 62 2e-08
BC051340-1|AAH51340.1| 757|Homo sapiens CD248 molecule, endosia... 62 2e-08
AL596222-1|CAH70182.1| 2471|Homo sapiens Notch homolog 2 (Drosop... 62 2e-08
AL512503-1|CAH72483.1| 2471|Homo sapiens Notch homolog 2 (Drosop... 62 2e-08
AL391824-1|CAI17865.1| 5635|Homo sapiens protein ( Human DNA seq... 62 2e-08
AL359752-4|CAI18974.1| 2471|Homo sapiens Notch homolog 2 (Drosop... 62 2e-08
AL135797-1|CAI17871.1| 5635|Homo sapiens protein ( Human DNA seq... 62 2e-08
AL135796-1|CAI17854.1| 5635|Homo sapiens protein ( Human DNA seq... 62 2e-08
AL133553-2|CAI17858.1| 5635|Homo sapiens protein ( Human DNA seq... 62 2e-08
AL133515-1|CAI17853.1| 5635|Homo sapiens protein ( Human DNA seq... 62 2e-08
AL121996-1|CAI17844.1| 5635|Homo sapiens protein ( Human DNA seq... 62 2e-08
AL118512-1|CAI17864.1| 5635|Homo sapiens protein ( Human DNA seq... 62 2e-08
AK027344-1|BAB55049.1| 741|Homo sapiens protein ( Homo sapiens ... 62 2e-08
AJ306906-1|CAC37630.1| 2673|Homo sapiens fibulin-6 protein. 62 2e-08
AJ295846-1|CAC34381.1| 757|Homo sapiens endosialin protein prot... 62 2e-08
AF315356-1|AAG37073.1| 2471|Homo sapiens NOTCH2 protein protein. 62 2e-08
AF308601-1|AAA36377.2| 2471|Homo sapiens NOTCH 2 protein. 62 2e-08
AF279142-1|AAG00867.1| 757|Homo sapiens tumor endothelial marke... 62 2e-08
AF156100-1|AAK68690.1| 5636|Homo sapiens hemicentin protein. 62 2e-08
Y00692-1|CAA68687.1| 676|Homo sapiens preproprotein S protein. 62 2e-08
M57853-1|AAA60357.1| 676|Homo sapiens S protein protein. 62 2e-08
M36564-1|AAA60180.1| 650|Homo sapiens PROS1 protein. 62 2e-08
M15036-1|AAA36479.1| 676|Homo sapiens protein ( Human vitamin K... 62 2e-08
BC015801-1|AAH15801.1| 676|Homo sapiens PROS1 protein protein. 62 2e-08
AY308744-1|AAP45054.1| 497|Homo sapiens protein S (alpha) protein. 62 2e-08
DQ217942-1|ABB70739.1| 886|Homo sapiens EGF-like module contain... 60 7e-08
BC059395-1|AAH59395.1| 821|Homo sapiens EMR1 protein protein. 60 7e-08
AB065918-1|BAC06133.1| 929|Homo sapiens seven transmembrane hel... 60 7e-08
D89629-1|BAB46925.1| 815|Homo sapiens cerebral protein-12 protein. 59 2e-07
D83018-1|BAA11681.1| 816|Homo sapiens nel-related protein 2 pro... 59 2e-07
BC020544-1|AAH20544.1| 816|Homo sapiens NELL2 protein protein. 59 2e-07
AY358336-1|AAQ88702.1| 509|Homo sapiens DFLL295 protein. 59 2e-07
AL133553-4|CAI17860.1| 240|Homo sapiens protein ( Human DNA seq... 58 2e-07
U97669-1|AAB91371.1| 2321|Homo sapiens Notch3 protein. 58 3e-07
AL592301-5|CAI13934.1| 2555|Homo sapiens Notch homolog 1, transl... 58 3e-07
AL354671-1|CAI16149.1| 2555|Homo sapiens Notch homolog 1, transl... 58 3e-07
AF058900-1|AAC14346.1| 2321|Homo sapiens Notch3 protein. 58 3e-07
AC004663-1|AAC15789.1| 2281|Homo sapiens Notch 3 protein. 58 3e-07
AB209447-1|BAD92684.1| 1289|Homo sapiens Notch homolog 3 variant... 58 3e-07
AB209121-1|BAD92358.1| 620|Homo sapiens Mutant p53 binding prot... 58 3e-07
BC126986-1|AAI26987.1| 393|Homo sapiens FLJ37440 protein protein. 58 4e-07
BC038242-1|AAH38242.1| 261|Homo sapiens Similar to RIKEN cDNA 1... 58 4e-07
BC035784-1|AAH35784.1| 439|Homo sapiens hypothetical protein FL... 58 4e-07
AK094759-1|BAC04416.1| 439|Homo sapiens protein ( Homo sapiens ... 58 4e-07
AC092645-2|AAY14854.1| 439|Homo sapiens unknown protein. 58 4e-07
AL117551-1|CAB55988.1| 511|Homo sapiens hypothetical protein pr... 57 5e-07
M73980-1|AAA60614.1| 2444|Homo sapiens TAN1 protein. 57 7e-07
L13720-1|AAA58494.1| 678|Homo sapiens growth-arrest-specific pr... 57 7e-07
BX072579-3|CAH71174.1| 678|Homo sapiens growth arrest-specific ... 57 7e-07
BC038984-1|AAH38984.1| 678|Homo sapiens growth arrest-specific ... 57 7e-07
AY256843-1|AAO84057.1| 678|Homo sapiens growth arrested-specifi... 57 7e-07
AK126533-1|BAC86580.1| 624|Homo sapiens protein ( Homo sapiens ... 57 7e-07
AF308602-1|AAG33848.1| 2556|Homo sapiens NOTCH 1 protein. 57 7e-07
AF054501-1|AAC39881.1| 161|Homo sapiens latent transforming gro... 57 7e-07
AF193055-1|AAG22483.1| 474|Homo sapiens unknown protein. 56 9e-07
D83017-1|BAA11680.1| 810|Homo sapiens nel-related protein protein. 56 1e-06
BC126440-1|AAI26441.1| 321|Homo sapiens OIT3 protein protein. 56 1e-06
BC096103-1|AAH96103.1| 763|Homo sapiens NELL1 protein protein. 56 1e-06
BC096102-1|AAH96102.1| 810|Homo sapiens NEL-like 1 (chicken) pr... 56 1e-06
BC096101-1|AAH96101.1| 810|Homo sapiens NEL-like 1 (chicken) pr... 56 1e-06
BC096100-1|AAH96100.1| 763|Homo sapiens NELL1 protein protein. 56 1e-06
BC069674-1|AAH69674.1| 810|Homo sapiens nel-like 1, precursor p... 56 1e-06
AY358339-1|AAQ88705.1| 545|Homo sapiens PPFL826 protein. 56 1e-06
AY013707-1|AAG40096.2| 545|Homo sapiens LZP protein. 56 1e-06
AK096435-1|BAC04788.1| 545|Homo sapiens protein ( Homo sapiens ... 56 1e-06
U95299-1|AAC32288.1| 2003|Homo sapiens Notch4 protein. 54 6e-06
U89335-1|AAC63097.1| 1999|Homo sapiens notch4 protein. 54 6e-06
D86566-1|BAA13116.1| 955|Homo sapiens notch related protein pro... 54 6e-06
BX284927-1|CAM25850.1| 2003|Homo sapiens Notch homolog 4 (Drosop... 54 6e-06
BX284686-1|CAM26209.1| 2003|Homo sapiens Notch homolog 4 (Drosop... 54 6e-06
BC063815-1|AAH63815.1| 647|Homo sapiens NOTCH4 protein protein. 54 6e-06
AL845509-1|CAI18564.1| 2003|Homo sapiens Notch homolog 4 (Drosop... 54 6e-06
AL845464-12|CAI41803.1| 2003|Homo sapiens Notch homolog 4 (Droso... 54 6e-06
AL662884-27|CAI18362.1| 2003|Homo sapiens Notch homolog 4 (Droso... 54 6e-06
AL662830-9|CAI17543.1| 2005|Homo sapiens Notch homolog 4 (Drosop... 54 6e-06
AB023961-1|BAB20317.1| 502|Homo sapiens notch4 protein. 54 6e-06
AK131562-1|BAD18695.1| 867|Homo sapiens protein ( Homo sapiens ... 52 1e-05
S54426-1|AAB25244.1| 109|Homo sapiens fibrillin protein. 52 2e-05
Y08725-1|CAA69975.1| 717|Homo sapiens BMP1-6 protein. 52 2e-05
Y08724-1|CAA69974.1| 622|Homo sapiens BMP1-5 protein. 52 2e-05
Y08545-1|CAA69849.1| 533|Homo sapiens complement 9 protein. 52 2e-05
X94630-1|CAA64333.1| 835|Homo sapiens seven-span transmembrane ... 52 2e-05
X02176-1|CAA26117.1| 559|Homo sapiens protein ( Human mRNA frag... 52 2e-05
U76764-1|AAB36682.1| 835|Homo sapiens CD97 protein. 52 2e-05
U50330-1|AAA93462.1| 986|Homo sapiens procollagen C-proteinase ... 52 2e-05
M22488-1|AAA51833.1| 730|Homo sapiens BMP1 protein. 52 2e-05
K02766-1|AAA51889.1| 557|Homo sapiens C9 protein. 52 2e-05
J02833-1|AAA51890.1| 98|Homo sapiens complement component C9 p... 52 2e-05
BC127005-1|AAI27006.1| 823|Homo sapiens egf-like module contain... 52 2e-05
BC127004-1|AAI27005.1| 823|Homo sapiens egf-like module contain... 52 2e-05
BC053933-1|AAH53933.1| 239|Homo sapiens EMR2 protein protein. 52 2e-05
BC034949-1|AAH34949.1| 239|Homo sapiens EMR2 protein protein. 52 2e-05
BC020721-1|AAH20721.1| 559|Homo sapiens complement component 9 ... 52 2e-05
AK222891-1|BAD96611.1| 810|Homo sapiens egf-like module contain... 52 2e-05
AF114491-1|AAF21974.1| 823|Homo sapiens EGF-like module EMR2 pr... 52 2e-05
AB209590-1|BAD92827.1| 803|Homo sapiens bone morphogenetic prot... 52 2e-05
AB065966-1|BAC06178.1| 837|Homo sapiens seven transmembrane hel... 52 2e-05
AB065931-1|BAC06146.1| 837|Homo sapiens seven transmembrane hel... 52 2e-05
M17778-1|AAA36799.1| 640|Homo sapiens protein ( Human uromoduli... 51 3e-05
M15881-1|AAA36798.1| 640|Homo sapiens protein ( Human uromoduli... 51 3e-05
BC035975-1|AAH35975.1| 611|Homo sapiens UMOD protein protein. 51 3e-05
AY162970-1|AAO64446.1| 640|Homo sapiens uromodulin precursor pr... 51 3e-05
AK074396-1|BAB85069.1| 220|Homo sapiens protein ( Homo sapiens ... 51 3e-05
AB209873-1|BAD93110.1| 2067|Homo sapiens notch1 preproprotein va... 51 3e-05
D61695-1|BAA34864.1| 699|Homo sapiens mannose-binding protein a... 51 4e-05
D28593-1|BAA05928.1| 699|Homo sapiens MASP protein. 51 4e-05
D17525-1|BAA04477.1| 699|Homo sapiens precursor of P100 serine ... 51 4e-05
BC106946-1|AAI06947.1| 728|Homo sapiens mannan-binding lectin s... 51 4e-05
BC106945-1|AAI06946.1| 728|Homo sapiens mannan-binding lectin s... 51 4e-05
BC039724-1|AAH39724.1| 488|Homo sapiens MASP1 protein protein. 51 4e-05
AF284421-1|AAK84071.1| 728|Homo sapiens complement factor MASP-... 51 4e-05
AB007617-1|BAA89206.1| 699|Homo sapiens MASP/P100 protein. 51 4e-05
U91963-1|AAB93878.1| 1013|Homo sapiens tolloid-like protein prot... 50 6e-05
AF282732-1|AAF86287.1| 1013|Homo sapiens tolloid-like protein pr... 50 6e-05
AC020594-1|AAY15036.1| 150|Homo sapiens unknown protein. 50 1e-04
AC013451-1|AAF87081.1| 969|Homo sapiens LTBP-2 protein. 50 1e-04
Y18287-2|CAB50735.1| 686|Homo sapiens MASP-2 protein. 49 1e-04
Y18287-1|CAB50734.1| 185|Homo sapiens MAp19 protein. 49 1e-04
Y18286-2|CAB50733.1| 686|Homo sapiens MASP-2 protein protein. 49 1e-04
Y18286-1|CAB50732.1| 185|Homo sapiens MAp19 protein protein. 49 1e-04
Y18284-1|CAB50731.1| 185|Homo sapiens mannose binding lectin-as... 49 1e-04
Y18283-1|CAB50730.1| 185|Homo sapiens mannose binding lectin-as... 49 1e-04
Y18282-1|CAB50729.1| 175|Homo sapiens mannose binding lectin-as... 49 1e-04
Y18281-1|CAB50728.1| 185|Homo sapiens mannose binding lectin-as... 49 1e-04
Y09926-1|CAA71059.1| 686|Homo sapiens MASP-2 protein protein. 49 1e-04
X98400-1|CAA67050.1| 686|Homo sapiens mannan-binding lectin-ass... 49 1e-04
AL109811-5|CAI22103.1| 185|Homo sapiens mannan-binding lectin s... 49 1e-04
AL109811-4|CAI22102.1| 686|Homo sapiens mannan-binding lectin s... 49 1e-04
AF321562-1|AAG50274.1| 686|Homo sapiens MBL-associated serine p... 49 1e-04
AF321558-1|AAG50275.1| 185|Homo sapiens MBL-associated protein ... 49 1e-04
AB033742-2|BAA85659.1| 181|Homo sapiens MBL-associated serine p... 49 1e-04
AB033742-1|BAA85658.1| 185|Homo sapiens small MBL-associated pr... 49 1e-04
AB008047-1|BAA78616.1| 185|Homo sapiens small MBL-associated pr... 49 1e-04
L38969-1|AAC41762.1| 956|Homo sapiens thrombospondin 3 protein. 47 5e-04
BC113847-1|AAI13848.1| 956|Homo sapiens thrombospondin 3, precu... 47 5e-04
BC113577-1|AAI13578.1| 1015|Homo sapiens tolloid-like 2 protein. 47 5e-04
BC112366-1|AAI12367.1| 1015|Homo sapiens tolloid-like 2 protein. 47 5e-04
BC112341-1|AAI12342.1| 1015|Homo sapiens tolloid-like 2 protein. 47 5e-04
AY899851-1|AAX85199.1| 730|Homo sapiens LGR8.1 protein. 47 5e-04
AL713999-15|CAI95084.1| 956|Homo sapiens thrombospondin 3 protein. 47 5e-04
AL391136-1|CAH72234.1| 1015|Homo sapiens tolloid-like 2 protein. 47 5e-04
AL159161-1|CAI17102.1| 754|Homo sapiens relaxin/insulin-like fa... 47 5e-04
AL138765-2|CAI13580.1| 1015|Homo sapiens tolloid-like 2 protein. 47 5e-04
AL138708-1|CAH73785.1| 754|Homo sapiens relaxin/insulin-like fa... 47 5e-04
AL136181-1|CAH72983.1| 1015|Homo sapiens tolloid-like 2 protein. 47 5e-04
AK223278-1|BAD96998.1| 956|Homo sapiens thrombospondin 3 precur... 47 5e-04
AF453828-1|AAL73946.1| 754|Homo sapiens G protein-coupled recep... 47 5e-04
AF403384-1|AAL69324.2| 754|Homo sapiens LGR8 protein. 47 5e-04
AF059516-1|AAD42979.1| 1015|Homo sapiens tolloid-like 2 protein ... 47 5e-04
AF023268-6|AAC51818.1| 736|Homo sapiens thrombospondin3 protein. 47 5e-04
AB023149-1|BAA76776.2| 1078|Homo sapiens KIAA0932 protein protein. 47 5e-04
DQ470677-1|ABF06669.1| 325|Homo sapiens CRELD2-gamma protein. 47 7e-04
BC088371-1|AAH88371.1| 273|Homo sapiens EGF-like-domain, multip... 47 7e-04
BC012377-1|AAH12377.1| 273|Homo sapiens EGF-like-domain, multip... 47 7e-04
AY358903-1|AAQ89262.1| 273|Homo sapiens VEMF protein. 47 7e-04
AY358902-1|AAQ89261.1| 273|Homo sapiens VEMF protein. 47 7e-04
AY358901-1|AAQ89260.1| 273|Homo sapiens VEMF protein. 47 7e-04
AL590226-1|CAH71721.1| 273|Homo sapiens EGF-like-domain, multip... 47 7e-04
AL513325-2|CAM17208.1| 1294|Homo sapiens crumbs homolog 1 (Droso... 47 7e-04
AL139136-3|CAM21656.1| 1294|Homo sapiens crumbs homolog 1 (Droso... 47 7e-04
AL136322-3|CAM23328.1| 1294|Homo sapiens crumbs homolog 1 (Droso... 47 7e-04
AJ748821-1|CAG38658.1| 1294|Homo sapiens crumbs homologue 1 (alt... 47 7e-04
AF186111-1|AAF01429.1| 273|Homo sapiens NOTCH4-like protein pro... 47 7e-04
AB125649-1|BAD01469.1| 273|Homo sapiens VE-statin protein. 47 7e-04
U89336-6|AAB47494.1| 293|Homo sapiens NG3 protein. 46 0.001
DQ470680-1|ABF06672.1| 373|Homo sapiens CRELD2-zeta protein. 46 0.001
DQ470678-1|ABF06670.1| 353|Homo sapiens CRELD2-delta protein. 46 0.001
BX284686-12|CAM26220.1| 293|Homo sapiens EGF-like-domain, multi... 46 0.001
BC052591-1|AAH52591.1| 293|Homo sapiens EGF-like-domain, multip... 46 0.001
BC035574-1|AAH35574.1| 293|Homo sapiens EGF-like-domain, multip... 46 0.001
AY358355-1|AAQ88721.1| 353|Homo sapiens RLPR185 protein. 46 0.001
AY358139-1|AAQ88506.1| 293|Homo sapiens NG3 protein. 46 0.001
AL845464-11|CAI41800.2| 293|Homo sapiens EGF-like-domain, multi... 46 0.001
AL662884-17|CAI18345.2| 293|Homo sapiens EGF-like-domain, multi... 46 0.001
AL662828-17|CAI17428.1| 293|Homo sapiens EGF-like-domain, multi... 46 0.001
AB190520-1|BAD51398.1| 293|Homo sapiens VE-statin2 protein. 46 0.001
X84076-1|CAA58883.1| 550|Homo sapiens DGCR2 gene protein. 46 0.001
X83545-1|CAA58536.1| 550|Homo sapiens cell surface protein prot... 46 0.001
D79985-1|BAA11480.1| 550|Homo sapiens KIAA0163 protein. 46 0.001
CR456433-1|CAG30319.1| 550|Homo sapiens DGCR2 protein. 46 0.001
BC050675-1|AAH50675.1| 353|Homo sapiens cysteine-rich with EGF-... 46 0.001
BC040500-1|AAH40500.1| 550|Homo sapiens DiGeorge syndrome criti... 46 0.001
BC032430-1|AAH32430.1| 550|Homo sapiens DiGeorge syndrome criti... 46 0.001
Y00406-1|CAA68467.1| 933|Homo sapiens protein ( Human mRNA for ... 46 0.002
X17358-1|CAA35235.1| 876|Homo sapiens protein ( Human mRNA from... 46 0.002
X04393-1|CAA27981.1| 545|Homo sapiens complement C8-beta propet... 46 0.002
M55702-2|AAA61218.1| 264|Homo sapiens thyroperoxidase protein. 46 0.002
M55702-1|AAA61219.1| 260|Homo sapiens thyroperoxidase protein. 46 0.002
M25715-1|AAA97517.1| 933|Homo sapiens TPO protein. 46 0.002
M17755-1|AAA61217.2| 933|Homo sapiens thyroid peroxidase protein. 46 0.002
M16973-1|AAA51862.1| 591|Homo sapiens C8B protein. 46 0.002
L35279-1|AAC41710.1| 284|Homo sapiens bone morphogenetic protei... 46 0.002
J02970-1|AAA61216.1| 876|Homo sapiens TPO protein. 46 0.002
J02969-1|AAA61215.1| 933|Homo sapiens TPO protein. 46 0.002
DQ011222-1|AAY16985.1| 933|Homo sapiens thyroid peroxidase prot... 46 0.002
BC130575-1|AAI30576.1| 591|Homo sapiens complement component 8,... 46 0.002
BC095448-1|AAH95448.1| 933|Homo sapiens thyroid peroxidase prot... 46 0.002
BC020701-1|AAH20701.1| 389|Homo sapiens Unknown (protein for IM... 46 0.002
AL121998-1|CAC18532.1| 591|Homo sapiens complement component 8,... 46 0.002
AF533530-1|AAN04473.1| 350|Homo sapiens thyroid peroxidase isof... 46 0.002
AC105450-1|AAX93261.1| 916|Homo sapiens unknown protein. 46 0.002
Y19124-1|CAB65555.1| 1019|Homo sapiens enteropeptidase protein. 45 0.002
U09860-1|AAC50138.1| 1019|Homo sapiens enterokinase protein. 45 0.002
BC111749-1|AAI11750.1| 1019|Homo sapiens protease, serine, 7 (en... 45 0.002
AL163217-2|CAB90389.1| 904|Homo sapiens human enterokinase; EC ... 45 0.002
AF020201-1|AAB71189.1| 1238|Homo sapiens Jagged 2 protein. 45 0.002
U08006-1|AAA82124.1| 584|Homo sapiens complement 8 alpha subuni... 45 0.003
M16974-1|AAA52200.1| 584|Homo sapiens C8A protein. 45 0.003
BC132913-1|AAI32914.1| 584|Homo sapiens complement component 8,... 45 0.003
BC132911-1|AAI32912.1| 584|Homo sapiens complement component 8,... 45 0.003
BC127709-1|AAI27710.1| 166|Homo sapiens Unknown (protein for MG... 45 0.003
BC127708-1|AAI27709.1| 205|Homo sapiens low density lipoprotein... 45 0.003
BC020702-1|AAH20702.1| 394|Homo sapiens Unknown (protein for IM... 45 0.003
AL353898-2|CAI22662.1| 116|Homo sapiens low density lipoprotein... 45 0.003
AL353898-1|CAI22661.1| 205|Homo sapiens low density lipoprotein... 45 0.003
AL121998-2|CAI19172.1| 584|Homo sapiens complement component 8,... 45 0.003
AF111170-2|AAD15562.1| 1238|Homo sapiens Jagged2 protein. 45 0.003
AF029778-1|AAB84215.1| 1238|Homo sapiens Jagged2 protein. 45 0.003
AF003521-1|AAB61285.1| 1238|Homo sapiens Jagged 2 protein. 45 0.003
X72177-1|CAA50994.1| 934|Homo sapiens complement component C6 p... 44 0.004
X02750-1|CAA26528.1| 461|Homo sapiens protein ( Human liver mRN... 44 0.004
M55683-1|AAA63904.1| 340|Homo sapiens cartilage matrix protein ... 44 0.004
>AB084910-1|BAD83615.1| 1905|Homo sapiens low density lipoprotein
receptor-related protein 10 protein.
Length = 1905
Score = 1179 bits (2920), Expect = 0.0
Identities = 605/1457 (41%), Positives = 867/1457 (59%), Gaps = 90/1457 (6%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C +F C + C+ ++CDGD DC D +DE +C C A +F+C+ G+C+ WR
Sbjct: 231 CRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNC--TTSMCTAEQFRCHSGRCVRLSWR 288
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV 382
CD E DCAD DE NC+ C+LD++ C + RC+ + LC+GV DC + DE
Sbjct: 289 CDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDE----- 343
Query: 383 SCEEDQYTCRPQEHLMSNAFRN--CVNRKHVCDGMKDCP------RGDDEERCPLKRKCS 434
Q CRP+ + N C + + G C +D C +C+
Sbjct: 344 ---SPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECA 400
Query: 435 AEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV---CSQTCSNTVG 491
E C + C T +G C C G+ L D+ SC+ + +PV ++ V
Sbjct: 401 EEGYCSQGC-TNSEGAFQCWCETGYELRPDRRSCKALGP-----EPVLLFANRIDIRQVL 454
Query: 492 SFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVW---LTGDNYMSVVK-GLHN- 546
R T + + L+F + + + ++ L G N VV GL +
Sbjct: 455 PHRSE-YTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLESP 513
Query: 547 -AVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWT 605
+A+D+ ++K ++W+++ I VA ++ + ++ LE P +A+ + ++WT
Sbjct: 514 GGLAVDWVHDK--LYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWT 571
Query: 606 DSG-TRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGD 664
D G T R+E +++DGS R ++ L P + + ++W D + IERA++DG
Sbjct: 572 DWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVD-AKHHVIERANLDGS 630
Query: 665 KRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERA-AFDGRDRRKVTTKGLPHPFAL 723
RK VI + P +T+ E +YW D I A F G+++ + K L P +
Sbjct: 631 HRKAVISQGLPHPFAITV--FEDSLYWTDWHTKSINSANKFTGKNQEIIRNK-LHFPMDI 687
Query: 724 TLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPM-------DIHSRSCEETPEKL 776
++ + N G + +G N I S +C ++ +K
Sbjct: 688 ----HTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQNYTCACPTGFRKISSHACAQSLDKF 743
Query: 777 LLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRA 836
LL+ARR D+R +++ D D VIP+ ++SAVALDWD + + ++WTDV DTI+RA
Sbjct: 744 LLFARRMDIRRISFDTE---DLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRA 800
Query: 837 YLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDK 896
+G+ Q +VD++L PAGLA DW+T+K+YWTD GT+RIEV+ +DGSMRT+L W+++D+
Sbjct: 801 KWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDR 860
Query: 897 PRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWT 956
PRDIVV P GG MYW+DWGASP IERA MD R+ +I +TWPNGLA+D R+YW
Sbjct: 861 PRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWA 920
Query: 957 DGGNKTIEYANLDGTGRTKLI-ENLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAKRR 1015
D G KTIE+A LDG+ R LI LPHPFGL LYG+ ++WTDW T+SIQ+A++ TG R
Sbjct: 921 DAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRE 980
Query: 1016 TLG----------------------CGKNNGGCSHLCLLKPG--GRSCACPIGIKLNKDG 1051
TL C NGGCSHLCL P G SC CP GI L DG
Sbjct: 981 TLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDG 1040
Query: 1052 KTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLP-PLKNALGVDVDHSTGLIYWTDT 1110
KTC+ G ++LIFA R+DIR++SLD+PY DVV+P+ +KN + V VD G +YW+D+
Sbjct: 1041 KTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITMKNTIAVGVDPQEGKVYWSDS 1100
Query: 1111 GQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKV 1170
+I RA G+ E +I GL T DG+ +D+ GRK+YWTD G N IEV LDG RKV
Sbjct: 1101 TLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKV 1160
Query: 1171 LVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDR 1230
LVW LDSPRAI L++E G+M+W+DWG +AK+ER+ MDG++R V+++N + WPNGL +D+
Sbjct: 1161 LVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDK 1220
Query: 1231 IEGRLYWNDAKILTIESSDFDGHDRRTVLSNVPYPYGIVIVGQHIYWTDWKTKALHRADK 1290
+L W DA IE++D +G +R T++S V +PYG+ ++ +IYWTDW+T+++HRADK
Sbjct: 1221 ASSQLLWADAHTERIEAADLNGANRHTLVSPVQHPYGLTLLDSYIYWTDWQTRSIHRADK 1280
Query: 1291 TNASDPIVIRKNLEGLMDIRAIQSERVLE-NACGTDNGGCSHLCLRSPLGYTCACPTGMP 1349
S+ I++R NL GLMD++A+ + L N CG+ NGGCSHLCL P G++CACPTG+
Sbjct: 1281 GTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQ 1340
Query: 1350 FEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDYHWD 1409
+ K C PE +L+F++RGSI ISL++ + DV +PV E+ N I++DY
Sbjct: 1341 LKGD-----GKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSV 1395
Query: 1410 LKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEV 1469
++YTD+ L+VIR ++ N S +T+I + L+T +GL VDW+A N+YWTD IE
Sbjct: 1396 DGKVYYTDVFLDVIRRADL-NGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEA 1454
Query: 1470 ARLDGSSRKVLI-TGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDL 1528
+RLDGS RKVLI L EPRA+A+FP KGYL+W+DWG IER+ LDGS+R++++ DL
Sbjct: 1455 SRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDL 1514
Query: 1529 GFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQLVPDAKNPFGMTQFKDYIYWTDW 1588
G+PNGLT+DY RR+YW DA DRI+++DLNG+ R LV +PF +TQ +IYWTDW
Sbjct: 1515 GWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVGHVSHPFALTQQDRWIYWTDW 1574
Query: 1589 YKKSIIRADKRTGKNITLIRTNLEMAMEIKAVSADRQHGWNPCKESNGGCSHLCLFRGHE 1648
KSI R DK +G+N + N+E M+I VS RQ G N C +NGGC+HLC R +
Sbjct: 1575 QTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVNNGGCTHLCFARASD 1634
Query: 1649 YICACPDDPDHVECSTV 1665
++CACPD+PD CS V
Sbjct: 1635 FVCACPDEPDSQPCSLV 1651
Score = 517 bits (1276), Expect = e-145
Identities = 234/517 (45%), Positives = 320/517 (61%), Gaps = 17/517 (3%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C +F+C +C+ + CDGD+DCGDW+DE C C +GEF C+ G CI WR
Sbjct: 191 CNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQ-PCRSGEFMCDSGLCINAGWR 249
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV 382
CD + DC D DE NC + C+ +++ C RCV +W CDG DC + DE NCE
Sbjct: 250 CDGDADCDDQSDERNCTTSM---CTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCEN 306
Query: 383 SCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKL 442
+ C + L N C+ ++ +C+G+ DC DE R + EE C
Sbjct: 307 TGSPQ---CALDQFLCWNG--RCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVN 361
Query: 443 ---CITTYD---GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCG 496
C G C C G+ L ED ++C+D++EC ++ CSQ C+N+ G+F+C
Sbjct: 362 NGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECA--EEGYCSQGCTNSEGAFQCW 419
Query: 497 CMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEK 556
C TGY LRPD RSCK G P LLF+NRI IRQV Y ++ L NA+ALD+H+ +
Sbjct: 420 CETGYELRPDRRSCKALGPEPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALDFHHRR 479
Query: 557 KLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVAT 616
+LVFWS+ L I A +N N+ +V+ GLE+P G+AVDW+HD L+WTDSGT R+EVA
Sbjct: 480 ELVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVAN 539
Query: 617 LDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFW 676
LDG+ R VL+ +L+KPRAIA+HP + ++WTDWG P+IE + MDG R+ + +FW
Sbjct: 540 LDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFW 599
Query: 677 PNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWH 736
PNGLTIDY ++YW DAKHHVIERA DG R+ V ++GLPHPFA+T+F+D++YWTDWH
Sbjct: 600 PNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWH 659
Query: 737 TKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETP 773
TKSI++ NK TG + + L+ PMDIH+ + P
Sbjct: 660 TKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQP 696
Score = 200 bits (489), Expect = 3e-50
Identities = 180/636 (28%), Positives = 267/636 (41%), Gaps = 77/636 (12%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
CI +W CDGDNDCGD SDE C + S L + + G I V
Sbjct: 44 CIPAQWQCDGDNDCGDHSDEDGCILPTCSPL----DFHCDNGKCIRRSWVCDG-DNDCED 98
Query: 233 IRYESFCAKKALDNAANP-------RSTWNQPVELMRCAEIDFECKNTKCVPKDFQ---- 281
E C + + P RS W+ + D +C KC K+F+
Sbjct: 99 DSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDG 158
Query: 282 --------CDGDNDCGDWTDEDSCP-MVPG-SCNAGEFKCNDGKCIPERWRCDNERDCAD 331
CDGD DC D +DE++CP VP CN EF+C G+CI + + CD + DC D
Sbjct: 159 SCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGD 218
Query: 332 GGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVS-CEEDQYT 390
DE +C +S + C E+ C C+ W CDG DC + DE NC S C +Q+
Sbjct: 219 WSDESDC--SSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFR 276
Query: 391 CRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPL--KRKCSAEE------KC--- 439
C CV CDG DC DEE C +C+ ++ +C
Sbjct: 277 CHS---------GRCVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQ 327
Query: 440 EKLCITTYD-GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCM 498
KLC D G + P + R +E + C+Q C G+ +C C
Sbjct: 328 RKLCNGVNDCGDNSDESP------QQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCH 381
Query: 499 TGYILRPDERSCKPTGESPTLLF-----SNRIGIRQVWLTGDNYMSVVKGLHNAVALDYH 553
TGY L D +C+ E + +N G Q W + + + AL
Sbjct: 382 TGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWC--ETGYELRPDRRSCKALG-- 437
Query: 554 YEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIH--DLLFWTDSGTRR 611
E L+F + ++R + + ++ ++ LE +A+D+ H +L+FW+D R
Sbjct: 438 PEPVLLFANRIDIRQV----LPHRSEYTLLLNNLEN--AIALDFHHRRELVFWSDVTLDR 491
Query: 612 VEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIY 671
+ A L+GS +V+ L+ P +AV ++WTD G + +IE A++DG RK +++
Sbjct: 492 ILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTS-RIEVANLDGAHRKVLLW 550
Query: 672 DEIFWPNGLTIDYTESKIYWAD-AKHHVIERAAFDGRDRRKVTTKGLPHPFALTL--FDD 728
+ P + + E IYW D IE ++ DG RR + L P LT+
Sbjct: 551 QNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGR 610
Query: 729 AIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDI 764
+YW D I N + + GL P I
Sbjct: 611 RMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAI 646
Score = 55.2 bits (127), Expect = 2e-06
Identities = 35/105 (33%), Positives = 43/105 (40%), Gaps = 5/105 (4%)
Query: 93 IDVIHTDPDDGPLNEGTEDDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXX 152
+D+ H D DD + E D PC F C S CI R
Sbjct: 205 LDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCD-SGLCINAGWRCDGDADCDDQSDER 263
Query: 153 XXXRS-CDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCD 196
S C + R CHS C+ L W CDG++DC D SDE NC+
Sbjct: 264 NCTTSMCTAEQFR--CHSGR-CVRLSWRCDGEDDCADNSDEENCE 305
Score = 46.4 bits (105), Expect = 0.001
Identities = 34/93 (36%), Positives = 41/93 (44%), Gaps = 7/93 (7%)
Query: 111 DDAGCITP-CLKINFSCQISCTCIPME-KRXXXXXXXXXXXXXXXXXRSCDEHENRTICH 168
D+ GCI P C ++F C + CI R C+E E C
Sbjct: 62 DEDGCILPTCSPLDFHCD-NGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFP--CQ 118
Query: 169 STNVCIALEWLCDGDNDCGDFSDEINCDVVKTS 201
+ CI W CDGDNDCGD SDE CD+ K S
Sbjct: 119 N-GYCIRSLWHCDGDNDCGDNSDE-QCDMRKCS 149
Score = 45.2 bits (102), Expect = 0.002
Identities = 22/40 (55%), Positives = 23/40 (57%), Gaps = 3/40 (7%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINC 195
R C + E R C S CIA W CDGD DC D SDE NC
Sbjct: 146 RKCSDKEFR--C-SDGSCIAEHWYCDGDTDCKDGSDEENC 182
>AB231861-1|BAE19679.1| 1950|Homo sapiens low-density lipoprotein
receptor-related protein 4 protein.
Length = 1950
Score = 1167 bits (2890), Expect = 0.0
Identities = 600/1456 (41%), Positives = 862/1456 (59%), Gaps = 91/1456 (6%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C +F C + C+ ++CDGD DC D +DE +C C A +F+C+ G+C+ WR
Sbjct: 279 CRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNC--TTSMCTAEQFRCHSGRCVRLSWR 336
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV 382
CD E DCAD DE NC+ C+LD++ C + RC+ + LC+GV DC + DE
Sbjct: 337 CDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDE----- 391
Query: 383 SCEEDQYTCRPQEHLMSNAFRN--CVNRKHVCDGMKDCP------RGDDEERCPLKRKCS 434
Q CRP+ + N C + + G C +D C +C+
Sbjct: 392 ---SPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECA 448
Query: 435 AEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV---CSQTCSNTVG 491
E C + C T +G C C G+ L D+ SC+ + +PV ++ V
Sbjct: 449 EEGYCSQGC-TNSEGAFQCWCETGYELRPDRRSCKALGP-----EPVLLFANRIDIRQVL 502
Query: 492 SFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVW---LTGDNYMSVVK-GLHN- 546
R T + + L+F + + + ++ L G N VV GL +
Sbjct: 503 PHRSE-YTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLESP 561
Query: 547 -AVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWT 605
+A+D+ ++K ++W+++ I VA ++ + ++ LE P +A+ + ++WT
Sbjct: 562 GGLAVDWVHDK--LYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWT 619
Query: 606 DSG-TRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGD 664
D G T R+E +++DGS R ++ L P + + ++W D + IERA++DG
Sbjct: 620 DWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVD-AKHHVIERANLDGS 678
Query: 665 KRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERA-AFDGRDRRKVTTKGLPHPFAL 723
RK VI + P +T+ E +YW D I A F G+++ + K L P +
Sbjct: 679 HRKAVISQGLPHPFAITV--FEDSLYWTDWHTKSINSANKFTGKNQEIIRNK-LHFPMDI 735
Query: 724 TLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPM-------DIHSRSCEETPEKL 776
++ + N G + +G N I S +C ++ +K
Sbjct: 736 ----HTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQNYTCACPTGFRKISSHACAQSLDKF 791
Query: 777 LLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRA 836
LL+ARR D+R +++ D D VIP+ ++SAVALDWD + + ++WTDV DTI+RA
Sbjct: 792 LLFARRMDIRRISFDTE---DLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRA 848
Query: 837 YLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDK 896
+G+ Q +VD++L PAGLA DW+T+K+YWTD GT+RIEV+ +DGSMRT+L W+++D+
Sbjct: 849 KWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDR 908
Query: 897 PRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWT 956
PRDIVV P GG MYW+DWGASP IERA MD R+ +I +TWPNGLA+D R+YW
Sbjct: 909 PRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWA 968
Query: 957 DGGNKTIEYANLDGTGRTKLI-ENLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAKRR 1015
D G KTIE+A LDG+ R LI LPHPFGL LYG+ ++WTDW T+SIQ+A++ TG R
Sbjct: 969 DAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRE 1028
Query: 1016 TLG----------------------CGKNNGGCSHLCLLKPG--GRSCACPIGIKLNKDG 1051
TL C NGGCSHLCL P G SC CP GI L DG
Sbjct: 1029 TLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDG 1088
Query: 1052 KTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLP-PLKNALGVDVDHSTGLIYWTDT 1110
KTC+ G ++LIFA R+DIR++SLD+PY DVV+P+ +KN + V VD G +YW+D+
Sbjct: 1089 KTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITMKNTIAVGVDPQEGKVYWSDS 1148
Query: 1111 GQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKV 1170
+I RA G+ E +I GL T DG+ +D+ GRK+YWTD G N IEV LDG RKV
Sbjct: 1149 TLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKV 1208
Query: 1171 LVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDR 1230
LVW LDSPRAI L++E G+M+W+DWG +AK+ER+ MDG++R V+++N + WPNGL +D+
Sbjct: 1209 LVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDK 1268
Query: 1231 IEGRLYWNDAKILTIESSDFDGHDRRTVLSNVPYPYGIVIVGQHIYWTDWKTKALHRADK 1290
+L W DA IE++D +G +R T++S V +PYG+ ++ +IYWTDW+T+++HRADK
Sbjct: 1269 ASSQLLWADAHTERIEAADLNGANRHTLVSPVQHPYGLTLLDSYIYWTDWQTRSIHRADK 1328
Query: 1291 TNASDPIVIRKNLEGLMDIRAIQSERVLE-NACGTDNGGCSHLCLRSPLGYTCACPTGMP 1349
S+ I++R NL GLMD++A+ + L N CG+ NGGCSHLCL P G++CACPTG+
Sbjct: 1329 GTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQ 1388
Query: 1350 FEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDYHWD 1409
+ K C PE +L+F++RGSI ISL++ + DV +PV E+ N I++DY
Sbjct: 1389 LKGD-----GKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSV 1443
Query: 1410 LKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEV 1469
++YTD+ L+VIR ++ N S +T+I + L+T +GL VDW+A N+YWTD IE
Sbjct: 1444 DGKVYYTDVFLDVIRRADL-NGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEA 1502
Query: 1470 ARLDGSSRKVLITGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLG 1529
+RLDGS RKVLI + +A FP KGYL+W+DWG IER+ LDGS+R++++ DLG
Sbjct: 1503 SRLDGSCRKVLINNSLDD--IAAFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLG 1560
Query: 1530 FPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQLVPDAKNPFGMTQFKDYIYWTDWY 1589
+PNGLT+DY RR+YW DA DRI+++DLNG+ R LV +PF +TQ +IYWTDW
Sbjct: 1561 WPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVGHVSHPFALTQQDRWIYWTDWQ 1620
Query: 1590 KKSIIRADKRTGKNITLIRTNLEMAMEIKAVSADRQHGWNPCKESNGGCSHLCLFRGHEY 1649
KSI R DK +G+N + N+E M+I VS RQ G N C +NGGC+HLC R ++
Sbjct: 1621 TKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVNNGGCTHLCFARASDF 1680
Query: 1650 ICACPDDPDHVECSTV 1665
+CACPD+PD CS V
Sbjct: 1681 VCACPDEPDSQPCSLV 1696
Score = 517 bits (1276), Expect = e-145
Identities = 234/517 (45%), Positives = 320/517 (61%), Gaps = 17/517 (3%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C +F+C +C+ + CDGD+DCGDW+DE C C +GEF C+ G CI WR
Sbjct: 239 CNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQ-PCRSGEFMCDSGLCINAGWR 297
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV 382
CD + DC D DE NC + C+ +++ C RCV +W CDG DC + DE NCE
Sbjct: 298 CDGDADCDDQSDERNCTTSM---CTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCEN 354
Query: 383 SCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKL 442
+ C + L N C+ ++ +C+G+ DC DE R + EE C
Sbjct: 355 TGSPQ---CALDQFLCWNG--RCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVN 409
Query: 443 ---CITTYD---GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCG 496
C G C C G+ L ED ++C+D++EC ++ CSQ C+N+ G+F+C
Sbjct: 410 NGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECA--EEGYCSQGCTNSEGAFQCW 467
Query: 497 CMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEK 556
C TGY LRPD RSCK G P LLF+NRI IRQV Y ++ L NA+ALD+H+ +
Sbjct: 468 CETGYELRPDRRSCKALGPEPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALDFHHRR 527
Query: 557 KLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVAT 616
+LVFWS+ L I A +N N+ +V+ GLE+P G+AVDW+HD L+WTDSGT R+EVA
Sbjct: 528 ELVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVAN 587
Query: 617 LDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFW 676
LDG+ R VL+ +L+KPRAIA+HP + ++WTDWG P+IE + MDG R+ + +FW
Sbjct: 588 LDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFW 647
Query: 677 PNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWH 736
PNGLTIDY ++YW DAKHHVIERA DG R+ V ++GLPHPFA+T+F+D++YWTDWH
Sbjct: 648 PNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWH 707
Query: 737 TKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETP 773
TKSI++ NK TG + + L+ PMDIH+ + P
Sbjct: 708 TKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQP 744
Score = 200 bits (489), Expect = 3e-50
Identities = 180/636 (28%), Positives = 267/636 (41%), Gaps = 77/636 (12%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
CI +W CDGDNDCGD SDE C + S L + + G I V
Sbjct: 92 CIPAQWQCDGDNDCGDHSDEDGCILPTCSPL----DFHCDNGKCIRRSWVCDG-DNDCED 146
Query: 233 IRYESFCAKKALDNAANP-------RSTWNQPVELMRCAEIDFECKNTKCVPKDFQ---- 281
E C + + P RS W+ + D +C KC K+F+
Sbjct: 147 DSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDG 206
Query: 282 --------CDGDNDCGDWTDEDSCP-MVPG-SCNAGEFKCNDGKCIPERWRCDNERDCAD 331
CDGD DC D +DE++CP VP CN EF+C G+CI + + CD + DC D
Sbjct: 207 SCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGD 266
Query: 332 GGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVS-CEEDQYT 390
DE +C +S + C E+ C C+ W CDG DC + DE NC S C +Q+
Sbjct: 267 WSDESDC--SSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFR 324
Query: 391 CRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPL--KRKCSAEE------KC--- 439
C CV CDG DC DEE C +C+ ++ +C
Sbjct: 325 CHS---------GRCVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQ 375
Query: 440 EKLCITTYD-GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCM 498
KLC D G + P + R +E + C+Q C G+ +C C
Sbjct: 376 RKLCNGVNDCGDNSDESP------QQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCH 429
Query: 499 TGYILRPDERSCKPTGESPTLLF-----SNRIGIRQVWLTGDNYMSVVKGLHNAVALDYH 553
TGY L D +C+ E + +N G Q W + + + AL
Sbjct: 430 TGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWC--ETGYELRPDRRSCKALG-- 485
Query: 554 YEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIH--DLLFWTDSGTRR 611
E L+F + ++R + + ++ ++ LE +A+D+ H +L+FW+D R
Sbjct: 486 PEPVLLFANRIDIRQV----LPHRSEYTLLLNNLEN--AIALDFHHRRELVFWSDVTLDR 539
Query: 612 VEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIY 671
+ A L+GS +V+ L+ P +AV ++WTD G + +IE A++DG RK +++
Sbjct: 540 ILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTS-RIEVANLDGAHRKVLLW 598
Query: 672 DEIFWPNGLTIDYTESKIYWAD-AKHHVIERAAFDGRDRRKVTTKGLPHPFALTL--FDD 728
+ P + + E IYW D IE ++ DG RR + L P LT+
Sbjct: 599 QNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGR 658
Query: 729 AIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDI 764
+YW D I N + + GL P I
Sbjct: 659 RMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAI 694
Score = 55.2 bits (127), Expect = 2e-06
Identities = 35/105 (33%), Positives = 43/105 (40%), Gaps = 5/105 (4%)
Query: 93 IDVIHTDPDDGPLNEGTEDDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXX 152
+D+ H D DD + E D PC F C S CI R
Sbjct: 253 LDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCD-SGLCINAGWRCDGDADCDDQSDER 311
Query: 153 XXXRS-CDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCD 196
S C + R CHS C+ L W CDG++DC D SDE NC+
Sbjct: 312 NCTTSMCTAEQFR--CHSGR-CVRLSWRCDGEDDCADNSDEENCE 353
Score = 46.4 bits (105), Expect = 0.001
Identities = 34/93 (36%), Positives = 41/93 (44%), Gaps = 7/93 (7%)
Query: 111 DDAGCITP-CLKINFSCQISCTCIPME-KRXXXXXXXXXXXXXXXXXRSCDEHENRTICH 168
D+ GCI P C ++F C + CI R C+E E C
Sbjct: 110 DEDGCILPTCSPLDFHCD-NGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFP--CQ 166
Query: 169 STNVCIALEWLCDGDNDCGDFSDEINCDVVKTS 201
+ CI W CDGDNDCGD SDE CD+ K S
Sbjct: 167 N-GYCIRSLWHCDGDNDCGDNSDE-QCDMRKCS 197
Score = 45.2 bits (102), Expect = 0.002
Identities = 22/40 (55%), Positives = 23/40 (57%), Gaps = 3/40 (7%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINC 195
R C + E R C S CIA W CDGD DC D SDE NC
Sbjct: 194 RKCSDKEFR--C-SDGSCIAEHWYCDGDTDCKDGSDEENC 230
>AB011540-1|BAA32468.1| 1576|Homo sapiens MEGF7 protein.
Length = 1576
Score = 1085 bits (2686), Expect = 0.0
Identities = 566/1356 (41%), Positives = 809/1356 (59%), Gaps = 88/1356 (6%)
Query: 364 LCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRN--CVNRKHVCDGMKDCP-- 419
LC+GV DC + DE Q CRP+ + N C + + G C
Sbjct: 1 LCNGVNDCGDNSDE--------SPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCH 52
Query: 420 ----RGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECM 475
+D C +C+ E C + C T +G C C G+ L D+ SC+ +
Sbjct: 53 TGYRLTEDGHTCQDVNECAEEGYCSQGC-TNSEGAFQCWCETGYELRPDRRSCKALGP-- 109
Query: 476 YEQDPV---CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVW- 531
+PV ++ V R T + + L+F + + + ++
Sbjct: 110 ---EPVLLFANRIDIRQVLPHRSE-YTLLLNNLENAIALDFHHRRELVFWSDVTLDRILR 165
Query: 532 --LTGDNYMSVVK-GLHN--AVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWG 586
L G N VV GL + +A+D+ ++K ++W+++ I VA ++ + ++
Sbjct: 166 ANLNGSNVEEVVSTGLESPGGLAVDWVHDK--LYWTDSGTSRIEVANLDGAHRKVLLWQN 223
Query: 587 LETPAGVAVDWIHDLLFWTDSG-TRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALV 645
LE P +A+ + ++WTD G T R+E +++DGS R ++ L P + + +
Sbjct: 224 LEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRM 283
Query: 646 FWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERA-AF 704
+W D + IERA++DG RK VI + P +T+ E +YW D I A F
Sbjct: 284 YWVD-AKHHVIERANLDGSHRKAVISQGLPHPFAITV--FEDSLYWTDWHTKSINSANKF 340
Query: 705 DGRDRRKVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPM-- 762
G+++ + K L P + ++ + N G + +G N
Sbjct: 341 TGKNQEIIRNK-LHFPMDI----HTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQNYTCAC 395
Query: 763 -----DIHSRSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWD 817
I S +C ++ +K LL+ARR D+R +++ D D VIP+ ++SAVALDWD
Sbjct: 396 PTGFRKISSHACAQSLDKFLLFARRMDIRRISFDTE---DLSDDVIPLADVRSAVALDWD 452
Query: 818 QKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIE 877
+ + ++WTDV DTI+RA +G+ Q +VD++L PAGLA DW+T+K+YWTD GT+RIE
Sbjct: 453 SRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIE 512
Query: 878 VSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQ 937
V+ +DGSMRT+L W+++D+PRDIVV P GG MYW+DWGASP IERA MD R+ +I
Sbjct: 513 VANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISSN 572
Query: 938 MTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLI-ENLPHPFGLDLYGDEVFWT 996
+TWPNGLA+D R+YW D G KTIE+A LDG+ R LI LPHPFGL LYG+ ++WT
Sbjct: 573 LTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWT 632
Query: 997 DWDTQSIQAANKDTGAKRRTLG----------------------CGKNNGGCSHLCLLKP 1034
DW T+SIQ+A++ TG R TL C NGGCSHLCL P
Sbjct: 633 DWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSP 692
Query: 1035 G--GRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLP-PLK 1091
G SC CP GI L DGKTC+ G ++LIFA R+DIR++SLD+PY DVV+P+ +K
Sbjct: 693 NPSGFSCTCPTGINLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITMK 752
Query: 1092 NALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWT 1151
N + V VD G +YW+D+ +I RA G+ E +I GL T DG+ +D+ GRK+YWT
Sbjct: 753 NTIAVGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWT 812
Query: 1152 DGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNN 1211
D G N IEV LDG RKVLVW LDSPRAI L++E G+M+W+DWG +AK+ER+ MDG++
Sbjct: 813 DTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSD 872
Query: 1212 RRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLSNVPYPYGIVIV 1271
R V+++N + WPNGL +D+ +L W DA IE++D +G +R T++S V +PYG+ ++
Sbjct: 873 RAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQHPYGLTLL 932
Query: 1272 GQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQSERVLE-NACGTDNGGCS 1330
+IYWTDW+T+++HRADK S+ I++R NL GLMD++A+ + L N CG+ NGGCS
Sbjct: 933 DSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGCS 992
Query: 1331 HLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWD 1390
HLCL P G++CACPTG+ + K C PE +L+F++RGSI ISL++ + D
Sbjct: 993 HLCLPRPSGFSCACPTGIQLKGD-----GKTCDPSPETYLLFSSRGSIRRISLDTSDHTD 1047
Query: 1391 VTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGV 1450
V +PV E+ N I++DY ++YTD+ L+VIR ++ N S +T+I + L+T +GL V
Sbjct: 1048 VHVPVPELNNVISLDYDSVDGKVYYTDVFLDVIRRADL-NGSNMETVIGRGLKTTDGLAV 1106
Query: 1451 DWIANNIYWTDNEHKVIEVARLDGSSRKVLI-TGLTEPRALALFPAKGYLYWSDWGEHPY 1509
DW+A N+YWTD IE +RLDGS RKVLI L EPRA+A+FP KGYL+W+DWG
Sbjct: 1107 DWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAK 1166
Query: 1510 IERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQLVPD 1569
IER+ LDGS+R++++ DLG+PNGLT+DY RR+YW DA DRI+++DLNG+ R LV
Sbjct: 1167 IERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVGH 1226
Query: 1570 AKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAVSADRQHGWN 1629
+PF +TQ +IYWTDW KSI R DK +G+N + N+E M+I VS RQ G N
Sbjct: 1227 VSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTN 1286
Query: 1630 PCKESNGGCSHLCLFRGHEYICACPDDPDHVECSTV 1665
C +NGGC+HLC R +++CACPD+PD CS V
Sbjct: 1287 ACGVNNGGCTHLCFARASDFVCACPDEPDSQPCSLV 1322
Score = 35.1 bits (77), Expect = 2.3
Identities = 35/115 (30%), Positives = 46/115 (40%), Gaps = 20/115 (17%)
Query: 282 CDGDNDCGDWTDEDSCPMVPGSCNAGEFKC--NDGKCIPERWRCDNERDCADGGDELNCK 339
C+G NDCGD +DE P GE C N+G C +C R + C
Sbjct: 2 CNGVNDCGDNSDES--PQQNCRPRTGEENCNVNNGGCAQ---KCQMVRGA------VQCT 50
Query: 340 PNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRP 393
++ + D +TC D C + + G CTN E C CE Y RP
Sbjct: 51 CHTGYRLTEDGHTCQDVNECAEEGYCSQG---CTNSEGAFQC--WCETG-YELRP 99
>AF283321-1|AAK52433.1| 1611|Homo sapiens low density lipoprotein
receptor-related protein 5 protein.
Length = 1611
Score = 780 bits (1928), Expect = 0.0
Identities = 395/923 (42%), Positives = 552/923 (59%), Gaps = 49/923 (5%)
Query: 776 LLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINR 835
LLL+A R+D+RL K L+ I V ++ A A+D+ +++WTDV ++ I +
Sbjct: 34 LLLFANRRDVRLVDAGGVK----LESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQ 89
Query: 836 AYLN--GSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDH 893
YLN G+ +V S L+ P GLA DW+ K+YWTD TNRIEV+ +G+ R +L W
Sbjct: 90 TYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQD 149
Query: 894 IDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRI 953
+D+PR I ++P G MYW+DWG +P IERA MDG RK ++ + WPNGL +DL ++
Sbjct: 150 LDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKL 209
Query: 954 YWTDGGNKTIEYANLDGTGRTKLIE-NLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGA 1012
YW D I ANLDG+ R K++E +L HPF L L GD ++WTDW T+SI A NK TG
Sbjct: 210 YWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGG 269
Query: 1013 KRRTL-----------------------GCGKNNGGCSHLCLLKPGGR--SCACPIGIKL 1047
KR+ + C ++NGGCSHLCLL P +CACP G++L
Sbjct: 270 KRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQL 329
Query: 1048 NKDGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNALGVDVDHSTGLIYW 1107
+G+TC G L+ A R D+R ISLD P D+VL + +++A+ +D D G +YW
Sbjct: 330 QDNGRTCKAGAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYW 389
Query: 1108 TDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRN 1167
TD R I+RA G+ +T++ ++ DGI +D R +YWTD G + IEV L+G +
Sbjct: 390 TDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTS 449
Query: 1168 RKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLA 1227
RK+LV LD PRAIALH G M+W+DWG + KIE A++DG RRV+V+ + WPNGLA
Sbjct: 450 RKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLA 509
Query: 1228 IDRIEGRLYWNDAKILTIESSDFDGHDRRTVLSN-VPYPYGIVIVGQHIYWTDWKTKALH 1286
+D EG+LYW DAK IE + DG RRT+L + +P+ +G ++G IYWTDW+ +++
Sbjct: 510 LDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIE 569
Query: 1287 RADKTNASDPIVIRKNLEGLMDIRAIQSERVL-ENACGTDNGGCSHLCLRSPLGYTCACP 1345
R K AS ++I L LM ++A+ +V+ N C NGGCSHLC +P C CP
Sbjct: 570 RVHKVKASRDVII-DQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRCGCP 628
Query: 1346 TGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVD 1405
G+ + +D K C PE FL+F +R +I ISLE+ DV +P+ VK A+D
Sbjct: 629 IGL---ELLSDM--KTC-IVPEAFLVFTSRAAIHRISLETNNN-DVAIPLTGVKEASALD 681
Query: 1406 YHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHK 1465
+ I++TD+ L I M N S + ++ L+ P G+ VDW+ N+YW D
Sbjct: 682 FDVSNNHIYWTDVSLKTISRAFM-NGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTN 740
Query: 1466 VIEVARLDGSSRKVLI-TGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIV 1524
IEVARLDG R+VL+ L PR+LAL P KGY+YW++WG P I R+++DG+ +V
Sbjct: 741 RIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLV 800
Query: 1525 QVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQLVPDAKNPFGMTQFKDYIY 1584
+G N LTIDY ++RLYWTD + I++S++ GQ RV + D +PFG+TQ+ DYIY
Sbjct: 801 D-KVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIY 859
Query: 1585 WTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAVSADRQHGWNPCKESNGGCSHLCLF 1644
WTDW SI RADK +G+N TLI+ +L+ M+I + RQ G N C +NG C LCL
Sbjct: 860 WTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLA 919
Query: 1645 RGHEYICACPD----DPDHVECS 1663
+ C C DP CS
Sbjct: 920 IPGGHRCGCASHYTLDPSSRNCS 942
Score = 690 bits (1705), Expect = 0.0
Identities = 405/1172 (34%), Positives = 624/1172 (53%), Gaps = 61/1172 (5%)
Query: 527 IRQVWL--TGDNYMSVV-KGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVI 583
I+Q +L TG +VV GL + L + K ++W+++ I VA +N + +
Sbjct: 87 IKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLF 146
Query: 584 RWGLETPAGVAVDWIHDLLFWTDSG-TRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGD 642
L+ P +A+D H ++WTD G T R+E A +DGS R ++V +D+ P + + +
Sbjct: 147 WQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEE 206
Query: 643 ALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERA 702
++W D I RA++DG R+ V+ + P LT+ + +YW D + I
Sbjct: 207 QKLYWAD-AKLSFIHRANLDGSFRQKVVEGSLTHPFALTL--SGDTLYWTDWQTRSIHAC 263
Query: 703 AFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGI-------QTVH 755
+RK L P + + +HT+ + + + T
Sbjct: 264 NKRTGGKRKEILSALYSPMDIQVLSQERQ-PFFHTRCEEDNGGCSHLCLLSPSEPFYTCA 322
Query: 756 AGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALD 815
V + + R+C+ E++LL ARR DLR L++ D D+V+ V+ I+ A+A+D
Sbjct: 323 CPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTP---DFTDIVLQVDDIRHAIAID 379
Query: 816 WDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNR 875
+D ++WTD E I RAYL+GS T+V++ + P G+A DW+ +YWTD GT+R
Sbjct: 380 YDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDR 439
Query: 876 IEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIF 935
IEV++ +G+ R +L + +D+PR I ++P G+MYW+DWG +P IE A++DG R+ L+
Sbjct: 440 IEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVN 499
Query: 936 GQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN-LPHPFGLDLYGDEVF 994
+ WPNGLALDL ++YW D IE N+DGT R L+E+ LPH FG L GD ++
Sbjct: 500 ASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLLGDFIY 559
Query: 995 WTDWDTQSIQAANKDTGAK------------------RRTLG---CGKNNGGCSHLCLLK 1033
WTDW +SI+ +K ++ + +G C NGGCSHLC
Sbjct: 560 WTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFT 619
Query: 1034 PGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNA 1093
P C CPIG++L D KTC P +L+F R I ISL+ DV +PL +K A
Sbjct: 620 PHATRCGCPIGLELLSDMKTCIV-PEAFLVFTSRAAIHRISLETNNN-DVAIPLTGVKEA 677
Query: 1094 LGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDG 1153
+D D S IYWTD + I RA G+ VE V+ GL +G+ +D G+ +YW D
Sbjct: 678 SALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADT 737
Query: 1154 GRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRR 1213
G N IEVA LDG+ R+VLVW LD+PR++AL GY++W++WG +I RA MDG N
Sbjct: 738 GTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCM 797
Query: 1214 VIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLSNVPYPYGIVIVGQ 1273
+VD K+ N L ID + RLYW D IESS+ G +R + ++P+P+G+
Sbjct: 798 TLVD-KVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSD 856
Query: 1274 HIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQSERVLE-NACGTDNGGCSHL 1332
+IYWTDW ++ RADKT+ + +I+ +L+ +MDI S R N C +NG C L
Sbjct: 857 YIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQL 916
Query: 1333 CLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVT 1392
CL P G+ C C + T D + + C S P FL+F+ + +I+ + + D+
Sbjct: 917 CLAIPGGHRCGCASHY-----TLDPSSRNC-SPPTTFLLFSQKSAISRMIPDDQHSPDLI 970
Query: 1393 LPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLET---PNGLG 1449
LP+ ++N A+DY K I++ D N+ R+ + T +SQ P+ L
Sbjct: 971 LPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLS 1030
Query: 1450 VDWIANNIYWTDNEHKVIEVARLDGSSRKVLITG-LTEPRALALFPAKGYLYWSDWGEHP 1508
+D + ++WT I V RL G + V++ G +PRA+ + +GYLY+++ +
Sbjct: 1031 IDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRA 1090
Query: 1509 Y-IERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQLV 1567
IER+ LDG++R+++ L P L +D +L+W DA RI++ DL+G +R+ L
Sbjct: 1091 AKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTL- 1149
Query: 1568 PDAK--NPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAVS--AD 1623
DA P G+T ++YW D ++ I R +K TG T I+ + I AV +
Sbjct: 1150 EDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSL 1209
Query: 1624 RQHGWNPCKESNGGCSHLCLFRGH-EYICACP 1654
+ +PC NGGCSH+C+ +G C+CP
Sbjct: 1210 EEFSAHPCARDNGGCSHICIAKGDGTPRCSCP 1241
Score = 454 bits (1119), Expect = e-126
Identities = 279/882 (31%), Positives = 443/882 (50%), Gaps = 53/882 (6%)
Query: 527 IRQVWLTGDNYMSVVKG-LHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRW 585
IR+ +L G ++V +++ + + + ++W++ I V ++N + ++
Sbjct: 397 IRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSE 456
Query: 586 GLETPAGVAVDWIHDLLFWTDSGTR-RVEVATLDGSKRAVLVANDLDKPRAIAVHPGDAL 644
L+ P +A+ + L++WTD G ++E A LDG +R VLV L P +A+ +
Sbjct: 457 DLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGK 516
Query: 645 VFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAF 704
++W D KIE ++DG KR+T++ D++ G T+ IYW D + IER
Sbjct: 517 LYWGD-AKTDKIEVINVDGTKRRTLLEDKLPHIFGFTL--LGDFIYWTDWQRRSIERV-H 572
Query: 705 DGRDRRKVTTKGLPHPFALTLFDDA-IYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMD 763
+ R V LP L + A + T+ + G + ++
Sbjct: 573 KVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRCGCPIGLE 632
Query: 764 IHS--RSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSN 821
+ S ++C PE L++ R + LE+ ++ D+ IP+ +K A ALD+D +N
Sbjct: 633 LLSDMKTCI-VPEAFLVFTSRAAIHRISLET----NNNDVAIPLTGVKEASALDFDVSNN 687
Query: 822 SIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKS 881
I+WTDV TI+RA++NGS +V+ L +P G+A DW+ +YW D GTNRIEV++
Sbjct: 688 HIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARL 747
Query: 882 DGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWP 941
DG R +L W +D PR + ++P G +YW++WG P I RA MDG N L+ ++
Sbjct: 748 DGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLV-DKVGRA 806
Query: 942 NGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIENLPHPFGLDLYGDEVFWTDWDTQ 1001
N L +D R+YWTD IE +N+ G R + ++LPHPFGL Y D ++WTDW+
Sbjct: 807 NDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLH 866
Query: 1002 SIQAANKDTGAKRRTL----------------------GCGKNNGGCSHLCLLKPGGRSC 1039
SI+ A+K +G R + C NNG C LCL PGG C
Sbjct: 867 SIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRC 926
Query: 1040 ACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNALGVDVD 1099
C L+ + C+ P +L+F+ + I + D + D++LPL L+N +D D
Sbjct: 927 GCASHYTLDPSSRNCSP-PTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYD 985
Query: 1100 HSTGLIYWTDTGQRKIQRATRLGTH--VETVIGNGLHT---ADGIVIDSTGRKIYWTDGG 1154
IYW D G++ I+RA GT V T + G + + ID R ++WT
Sbjct: 986 PLDKFIYWVD-GRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEA 1044
Query: 1155 RNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDW-GTSAKIERADMDGNNRR 1213
N+I V L G V++ D PRAI ++ E GY+++++ +AKIERA +DG R
Sbjct: 1045 TNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTERE 1104
Query: 1214 VIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVL-SNVPYPYGIVIVG 1272
V+ + P L +D G+L+W DA + IES D G +R T+ +N+ P G+ I+G
Sbjct: 1105 VLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILG 1164
Query: 1273 QHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQS---ERVLENACGTDNGGC 1329
+H+YW D + + + R +KT I+ + L I A++ E + C DNGGC
Sbjct: 1165 KHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGC 1224
Query: 1330 SHLCLRSPLGY-TCACPTGMP-FEKSTTDQTPKKCKSHPEEF 1369
SH+C+ G C+CP + + T P C P++F
Sbjct: 1225 SHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCS--PDQF 1264
Score = 316 bits (776), Expect = 5e-85
Identities = 194/521 (37%), Positives = 268/521 (51%), Gaps = 23/521 (4%)
Query: 512 PTGESPTLLFSNRIGIRQVWLTGDNYMS--VVKGLHNAVALDYHYEKKLVFWSENNLRVI 569
P SP LLF+NR +R V G S VV GL +A A+D+ + K V+W++ + I
Sbjct: 28 PAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAI 87
Query: 570 RVAQMNTKN--MSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVA 627
+ +N + +V+ GL +P G+A DW+ L+WTDS T R+EVA L+G+ R VL
Sbjct: 88 KQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFW 147
Query: 628 NDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTES 687
DLD+PRAIA+ P ++WTDWG P+IERA MDG RK ++ +I+WPNGLTID E
Sbjct: 148 QDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQ 207
Query: 688 KIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNT 747
K+YWADAK I RA DG R+KV L HPFALTL D +YWTDW T+SI NK T
Sbjct: 208 KLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRT 267
Query: 748 GMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRKD-----LRLKQLESKKPIDSLDMV 802
G + + + L PMDI S E P + R ++ L L +P +
Sbjct: 268 GGKRKEILSALYSPMDIQVLSQERQP---FFHTRCEEDNGGCSHLCLLSPSEPFYTCACP 324
Query: 803 IPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIV--DSNLIWPAGLAFD 860
V+ + + + + + R L+ T IV ++ + +D
Sbjct: 325 TGVQLQDNGRTCKAGAEEVLLL---ARRTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYD 381
Query: 861 WITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCI 920
+ +YWTD I + DGS L I+ P I V+ +YW+D G I
Sbjct: 382 PLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDR-I 440
Query: 921 ERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTD-GGNKTIEYANLDGTGRTKLIE- 978
E ++G +RK L+ + P +AL V +YWTD G N IE ANLDG R L+
Sbjct: 441 EVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNA 500
Query: 979 --NLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTL 1017
P+ LDL +++W D T I+ N D G KRRTL
Sbjct: 501 SLGWPNGLALDLQEGKLYWGDAKTDKIEVINVD-GTKRRTL 540
Score = 245 bits (600), Expect = 1e-63
Identities = 173/556 (31%), Positives = 278/556 (50%), Gaps = 38/556 (6%)
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWL-TGDNYMSV 540
CS C T + RCGC G L D ++C L+F++R I ++ L T +N +++
Sbjct: 612 CSHLCFFTPHATRCGCPIGLELLSDMKTC--IVPEAFLVFTSRAAIHRISLETNNNDVAI 669
Query: 541 -VKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIH 599
+ G+ A ALD+ ++W++ +L+ I A MN ++ V+ +GL+ P G+AVDW+
Sbjct: 670 PLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMG 729
Query: 600 DLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERA 659
L+W D+GT R+EVA LDG R VLV DLD PR++A+ P ++WT+WG P+I RA
Sbjct: 730 KNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRA 789
Query: 660 DMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPH 719
MDG T++ D++ N LTIDY + ++YW D ++IE + G++ R V LPH
Sbjct: 790 FMDGTNCMTLV-DKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQE-RVVIADDLPH 847
Query: 720 PFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLY 779
PF LT + D IYWTDW+ SI +K +G + L+ MDI L+ +
Sbjct: 848 PFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDI-----------LVFH 896
Query: 780 ARRKDLRLKQLESKKPIDSLDMVIPVE---TIKSAVALDWDQKSNS---IFWTDVEKDTI 833
+ R+D + + L + IP S LD ++ S F +K I
Sbjct: 897 SSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAI 956
Query: 834 NRAYLNGSHQTTIV--DSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGS----MRT 887
+R + H ++ L + +D + IYW DG N I+ +K DG+ + +
Sbjct: 957 SRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQN-IKRAKDDGTQPFVLTS 1015
Query: 888 LLAWDHIDK-PRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLAL 946
L + D+ P D+ ++ ++W+ A+ I + G ++ G P + +
Sbjct: 1016 LSQGQNPDRQPHDLSIDIYSRTLFWT-CEATNTINVHRLSGEAMGVVLRGDRDKPRAIVV 1074
Query: 947 DLVHNRIYWTDGGNKT--IEYANLDGTGRTKLI-ENLPHPFGL--DLYGDEVFWTDWDTQ 1001
+ +Y+T+ ++ IE A LDGT R L L P L D ++FW D D +
Sbjct: 1075 NAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLK 1134
Query: 1002 SIQAANKDTGAKRRTL 1017
I++ + +GA R TL
Sbjct: 1135 RIESCDL-SGANRLTL 1149
Score = 235 bits (575), Expect = 1e-60
Identities = 111/274 (40%), Positives = 164/274 (59%), Gaps = 6/274 (2%)
Query: 477 EQDPVCSQTC--SNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTG 534
E + CS C S + + C C TG L+ + R+CK G LL + R +R++ L
Sbjct: 301 EDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCK-AGAEEVLLLARRTDLRRISLDT 359
Query: 535 DNYMSVV---KGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPA 591
++ +V + +A+A+DY + V+W+++ +R IR A ++ ++ + P
Sbjct: 360 PDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPD 419
Query: 592 GVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWG 651
G+AVDW+ L+WTD+GT R+EV L+G+ R +LV+ DLD+PRAIA+HP L++WTDWG
Sbjct: 420 GIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWG 479
Query: 652 PNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRK 711
NPKIE A++DG +R+ ++ + WPNGL +D E K+YW DAK IE DG RR
Sbjct: 480 ENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRT 539
Query: 712 VTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNK 745
+ LPH F TL D IYWTDW +SI V+K
Sbjct: 540 LLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHK 573
Score = 134 bits (324), Expect = 3e-30
Identities = 83/286 (29%), Positives = 129/286 (45%), Gaps = 11/286 (3%)
Query: 471 IDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQV 530
+++CM+ C Q C G RCGC + Y L P R+C P + LLFS + I ++
Sbjct: 903 LNDCMHNNGQ-CGQLCLAIPGGHRCGCASHYTLDPSSRNCSPP--TTFLLFSQKSAISRM 959
Query: 531 WLTGDNYMSVV---KGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKN-MSDVIRWG 586
+ ++ GL N A+DY K ++W + + R T+ + + G
Sbjct: 960 IPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQG 1019
Query: 587 LET---PAGVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDA 643
P +++D LFWT T + V L G V++ D DKPRAI V+
Sbjct: 1020 QNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERG 1079
Query: 644 LVFWTDWGPNP-KIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERA 702
+++T+ KIERA +DG +R+ + + P L +D T K++W DA IE
Sbjct: 1080 YLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESC 1139
Query: 703 AFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTG 748
G +R + + P LT+ +YW D + I V K TG
Sbjct: 1140 DLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTG 1185
Score = 102 bits (244), Expect = 1e-20
Identities = 47/123 (38%), Positives = 71/123 (57%), Gaps = 10/123 (8%)
Query: 263 CAEIDFECKNTK--CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPER 320
C+ F C + C+P ++CDG +C D +DE+ CP+ C+A +F C G+C+ R
Sbjct: 1259 CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV----CSAAQFPCARGQCVDLR 1314
Query: 321 WRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC 380
RCD E DC D DE +C ++I C +++ CA +CVL CD DC +G DE+ C
Sbjct: 1315 LRCDGEADCQDRSDEADC--DAI--CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
Query: 381 EVS 383
E++
Sbjct: 1371 EIT 1373
Score = 85.8 bits (203), Expect = 1e-15
Identities = 48/146 (32%), Positives = 64/146 (43%), Gaps = 16/146 (10%)
Query: 301 PGSCNAGEFKCNDGK--CIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRC 358
P +C+ +F C G+ CIP WRCD +C D DE C CS ++ CA +C
Sbjct: 1256 PPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV-----CSAAQFPCARGQC 1310
Query: 359 VLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDC 418
V CDG DC + DE +C+ C +Q+ C A CV K CD DC
Sbjct: 1311 VDLRLRCDGEADCQDRSDEADCDAICLPNQFRC---------ASGQCVLIKQQCDSFPDC 1361
Query: 419 PRGDDEERCPLKRKCSAEEKCEKLCI 444
G DE C + + S + I
Sbjct: 1362 IDGSDELMCEITKPPSDDSPAHSSAI 1387
Score = 38.3 bits (85), Expect = 0.25
Identities = 18/72 (25%), Positives = 31/72 (43%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCM 498
C +CI DG C+CP+ +L ++ +C + C +Q + G++RC
Sbjct: 1224 CSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGF 1283
Query: 499 TGYILRPDERSC 510
+ DE C
Sbjct: 1284 PECDDQSDEEGC 1295
Score = 36.3 bits (80), Expect = 1.00
Identities = 13/26 (50%), Positives = 17/26 (65%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVV 198
C+ L CDG+ DC D SDE +CD +
Sbjct: 1310 CVDLRLRCDGEADCQDRSDEADCDAI 1335
Score = 33.9 bits (74), Expect = 5.3
Identities = 31/117 (26%), Positives = 45/117 (38%), Gaps = 6/117 (5%)
Query: 101 DDGPLNEGTEDDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDE 160
D P + D+ GC C F C C+ + R C
Sbjct: 1281 DGFPECDDQSDEEGCPV-CSAAQFPCARG-QCVDLRLRCDGEADCQDRSDEADCDAICLP 1338
Query: 161 HENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVI 217
++ R C S C+ ++ CD DC D SDE+ C++ K A++S IG VI
Sbjct: 1339 NQFR--CASGQ-CVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSA-IGPVI 1391
>AF077820-1|AAC72791.1| 1615|Homo sapiens LDL receptor member LR3
protein.
Length = 1615
Score = 780 bits (1928), Expect = 0.0
Identities = 395/923 (42%), Positives = 552/923 (59%), Gaps = 49/923 (5%)
Query: 776 LLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINR 835
LLL+A R+D+RL K L+ I V ++ A A+D+ +++WTDV ++ I +
Sbjct: 34 LLLFANRRDVRLVDAGGVK----LESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQ 89
Query: 836 AYLN--GSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDH 893
YLN G+ +V S L+ P GLA DW+ K+YWTD TNRIEV+ +G+ R +L W
Sbjct: 90 TYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQD 149
Query: 894 IDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRI 953
+D+PR I ++P G MYW+DWG +P IERA MDG RK ++ + WPNGL +DL ++
Sbjct: 150 LDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKL 209
Query: 954 YWTDGGNKTIEYANLDGTGRTKLIE-NLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGA 1012
YW D I ANLDG+ R K++E +L HPF L L GD ++WTDW T+SI A NK TG
Sbjct: 210 YWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGG 269
Query: 1013 KRRTL-----------------------GCGKNNGGCSHLCLLKPGGR--SCACPIGIKL 1047
KR+ + C ++NGGCSHLCLL P +CACP G++L
Sbjct: 270 KRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQL 329
Query: 1048 NKDGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNALGVDVDHSTGLIYW 1107
+G+TC G L+ A R D+R ISLD P D+VL + +++A+ +D D G +YW
Sbjct: 330 QDNGRTCKAGAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYW 389
Query: 1108 TDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRN 1167
TD R I+RA G+ +T++ ++ DGI +D R +YWTD G + IEV L+G +
Sbjct: 390 TDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTS 449
Query: 1168 RKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLA 1227
RK+LV LD PRAIALH G M+W+DWG + KIE A++DG RRV+V+ + WPNGLA
Sbjct: 450 RKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLA 509
Query: 1228 IDRIEGRLYWNDAKILTIESSDFDGHDRRTVLSN-VPYPYGIVIVGQHIYWTDWKTKALH 1286
+D EG+LYW DAK IE + DG RRT+L + +P+ +G ++G IYWTDW+ +++
Sbjct: 510 LDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIE 569
Query: 1287 RADKTNASDPIVIRKNLEGLMDIRAIQSERVL-ENACGTDNGGCSHLCLRSPLGYTCACP 1345
R K AS ++I L LM ++A+ +V+ N C NGGCSHLC +P C CP
Sbjct: 570 RVHKVKASRDVII-DQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRCGCP 628
Query: 1346 TGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVD 1405
G+ + +D K C PE FL+F +R +I ISLE+ DV +P+ VK A+D
Sbjct: 629 IGL---ELLSDM--KTC-IVPEAFLVFTSRAAIHRISLETNNN-DVAIPLTGVKEASALD 681
Query: 1406 YHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHK 1465
+ I++TD+ L I M N S + ++ L+ P G+ VDW+ N+YW D
Sbjct: 682 FDVSNNHIYWTDVSLKTISRAFM-NGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTN 740
Query: 1466 VIEVARLDGSSRKVLI-TGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIV 1524
IEVARLDG R+VL+ L PR+LAL P KGY+YW++WG P I R+++DG+ +V
Sbjct: 741 RIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLV 800
Query: 1525 QVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQLVPDAKNPFGMTQFKDYIY 1584
+G N LTIDY ++RLYWTD + I++S++ GQ RV + D +PFG+TQ+ DYIY
Sbjct: 801 D-KVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIY 859
Query: 1585 WTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAVSADRQHGWNPCKESNGGCSHLCLF 1644
WTDW SI RADK +G+N TLI+ +L+ M+I + RQ G N C +NG C LCL
Sbjct: 860 WTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLA 919
Query: 1645 RGHEYICACPD----DPDHVECS 1663
+ C C DP CS
Sbjct: 920 IPGGHRCGCASHYTLDPSSRNCS 942
Score = 690 bits (1705), Expect = 0.0
Identities = 405/1172 (34%), Positives = 624/1172 (53%), Gaps = 61/1172 (5%)
Query: 527 IRQVWL--TGDNYMSVV-KGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVI 583
I+Q +L TG +VV GL + L + K ++W+++ I VA +N + +
Sbjct: 87 IKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLF 146
Query: 584 RWGLETPAGVAVDWIHDLLFWTDSG-TRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGD 642
L+ P +A+D H ++WTD G T R+E A +DGS R ++V +D+ P + + +
Sbjct: 147 WQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEE 206
Query: 643 ALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERA 702
++W D I RA++DG R+ V+ + P LT+ + +YW D + I
Sbjct: 207 QKLYWAD-AKLSFIHRANLDGSFRQKVVEGSLTHPFALTL--SGDTLYWTDWQTRSIHAC 263
Query: 703 AFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGI-------QTVH 755
+RK L P + + +HT+ + + + T
Sbjct: 264 NKRTGGKRKEILSALYSPMDIQVLSQERQ-PFFHTRCEEDNGGCSHLCLLSPSEPFYTCA 322
Query: 756 AGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALD 815
V + + R+C+ E++LL ARR DLR L++ D D+V+ V+ I+ A+A+D
Sbjct: 323 CPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTP---DFTDIVLQVDDIRHAIAID 379
Query: 816 WDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNR 875
+D ++WTD E I RAYL+GS T+V++ + P G+A DW+ +YWTD GT+R
Sbjct: 380 YDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDR 439
Query: 876 IEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIF 935
IEV++ +G+ R +L + +D+PR I ++P G+MYW+DWG +P IE A++DG R+ L+
Sbjct: 440 IEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVN 499
Query: 936 GQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN-LPHPFGLDLYGDEVF 994
+ WPNGLALDL ++YW D IE N+DGT R L+E+ LPH FG L GD ++
Sbjct: 500 ASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLLGDFIY 559
Query: 995 WTDWDTQSIQAANKDTGAK------------------RRTLG---CGKNNGGCSHLCLLK 1033
WTDW +SI+ +K ++ + +G C NGGCSHLC
Sbjct: 560 WTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFT 619
Query: 1034 PGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNA 1093
P C CPIG++L D KTC P +L+F R I ISL+ DV +PL +K A
Sbjct: 620 PHATRCGCPIGLELLSDMKTCIV-PEAFLVFTSRAAIHRISLETNNN-DVAIPLTGVKEA 677
Query: 1094 LGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDG 1153
+D D S IYWTD + I RA G+ VE V+ GL +G+ +D G+ +YW D
Sbjct: 678 SALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADT 737
Query: 1154 GRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRR 1213
G N IEVA LDG+ R+VLVW LD+PR++AL GY++W++WG +I RA MDG N
Sbjct: 738 GTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCM 797
Query: 1214 VIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLSNVPYPYGIVIVGQ 1273
+VD K+ N L ID + RLYW D IESS+ G +R + ++P+P+G+
Sbjct: 798 TLVD-KVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSD 856
Query: 1274 HIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQSERVLE-NACGTDNGGCSHL 1332
+IYWTDW ++ RADKT+ + +I+ +L+ +MDI S R N C +NG C L
Sbjct: 857 YIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQL 916
Query: 1333 CLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVT 1392
CL P G+ C C + T D + + C S P FL+F+ + +I+ + + D+
Sbjct: 917 CLAIPGGHRCGCASHY-----TLDPSSRNC-SPPTTFLLFSQKSAISRMIPDDQHSPDLI 970
Query: 1393 LPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLET---PNGLG 1449
LP+ ++N A+DY K I++ D N+ R+ + T +SQ P+ L
Sbjct: 971 LPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLS 1030
Query: 1450 VDWIANNIYWTDNEHKVIEVARLDGSSRKVLITG-LTEPRALALFPAKGYLYWSDWGEHP 1508
+D + ++WT I V RL G + V++ G +PRA+ + +GYLY+++ +
Sbjct: 1031 IDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRA 1090
Query: 1509 Y-IERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQLV 1567
IER+ LDG++R+++ L P L +D +L+W DA RI++ DL+G +R+ L
Sbjct: 1091 AKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTL- 1149
Query: 1568 PDAK--NPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAVS--AD 1623
DA P G+T ++YW D ++ I R +K TG T I+ + I AV +
Sbjct: 1150 EDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSL 1209
Query: 1624 RQHGWNPCKESNGGCSHLCLFRGH-EYICACP 1654
+ +PC NGGCSH+C+ +G C+CP
Sbjct: 1210 EEFSAHPCARDNGGCSHICIAKGDGTPRCSCP 1241
Score = 454 bits (1119), Expect = e-126
Identities = 279/882 (31%), Positives = 443/882 (50%), Gaps = 53/882 (6%)
Query: 527 IRQVWLTGDNYMSVVKG-LHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRW 585
IR+ +L G ++V +++ + + + ++W++ I V ++N + ++
Sbjct: 397 IRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSE 456
Query: 586 GLETPAGVAVDWIHDLLFWTDSGTR-RVEVATLDGSKRAVLVANDLDKPRAIAVHPGDAL 644
L+ P +A+ + L++WTD G ++E A LDG +R VLV L P +A+ +
Sbjct: 457 DLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGK 516
Query: 645 VFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAF 704
++W D KIE ++DG KR+T++ D++ G T+ IYW D + IER
Sbjct: 517 LYWGD-AKTDKIEVINVDGTKRRTLLEDKLPHIFGFTL--LGDFIYWTDWQRRSIERV-H 572
Query: 705 DGRDRRKVTTKGLPHPFALTLFDDA-IYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMD 763
+ R V LP L + A + T+ + G + ++
Sbjct: 573 KVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRCGCPIGLE 632
Query: 764 IHS--RSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSN 821
+ S ++C PE L++ R + LE+ ++ D+ IP+ +K A ALD+D +N
Sbjct: 633 LLSDMKTCI-VPEAFLVFTSRAAIHRISLET----NNNDVAIPLTGVKEASALDFDVSNN 687
Query: 822 SIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKS 881
I+WTDV TI+RA++NGS +V+ L +P G+A DW+ +YW D GTNRIEV++
Sbjct: 688 HIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARL 747
Query: 882 DGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWP 941
DG R +L W +D PR + ++P G +YW++WG P I RA MDG N L+ ++
Sbjct: 748 DGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLV-DKVGRA 806
Query: 942 NGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIENLPHPFGLDLYGDEVFWTDWDTQ 1001
N L +D R+YWTD IE +N+ G R + ++LPHPFGL Y D ++WTDW+
Sbjct: 807 NDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLH 866
Query: 1002 SIQAANKDTGAKRRTL----------------------GCGKNNGGCSHLCLLKPGGRSC 1039
SI+ A+K +G R + C NNG C LCL PGG C
Sbjct: 867 SIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRC 926
Query: 1040 ACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNALGVDVD 1099
C L+ + C+ P +L+F+ + I + D + D++LPL L+N +D D
Sbjct: 927 GCASHYTLDPSSRNCSP-PTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYD 985
Query: 1100 HSTGLIYWTDTGQRKIQRATRLGTH--VETVIGNGLHT---ADGIVIDSTGRKIYWTDGG 1154
IYW D G++ I+RA GT V T + G + + ID R ++WT
Sbjct: 986 PLDKFIYWVD-GRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEA 1044
Query: 1155 RNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDW-GTSAKIERADMDGNNRR 1213
N+I V L G V++ D PRAI ++ E GY+++++ +AKIERA +DG R
Sbjct: 1045 TNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTERE 1104
Query: 1214 VIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVL-SNVPYPYGIVIVG 1272
V+ + P L +D G+L+W DA + IES D G +R T+ +N+ P G+ I+G
Sbjct: 1105 VLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILG 1164
Query: 1273 QHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQS---ERVLENACGTDNGGC 1329
+H+YW D + + + R +KT I+ + L I A++ E + C DNGGC
Sbjct: 1165 KHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGC 1224
Query: 1330 SHLCLRSPLGY-TCACPTGMP-FEKSTTDQTPKKCKSHPEEF 1369
SH+C+ G C+CP + + T P C P++F
Sbjct: 1225 SHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCS--PDQF 1264
Score = 316 bits (776), Expect = 5e-85
Identities = 194/521 (37%), Positives = 268/521 (51%), Gaps = 23/521 (4%)
Query: 512 PTGESPTLLFSNRIGIRQVWLTGDNYMS--VVKGLHNAVALDYHYEKKLVFWSENNLRVI 569
P SP LLF+NR +R V G S VV GL +A A+D+ + K V+W++ + I
Sbjct: 28 PAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAI 87
Query: 570 RVAQMNTKN--MSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVA 627
+ +N + +V+ GL +P G+A DW+ L+WTDS T R+EVA L+G+ R VL
Sbjct: 88 KQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFW 147
Query: 628 NDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTES 687
DLD+PRAIA+ P ++WTDWG P+IERA MDG RK ++ +I+WPNGLTID E
Sbjct: 148 QDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQ 207
Query: 688 KIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNT 747
K+YWADAK I RA DG R+KV L HPFALTL D +YWTDW T+SI NK T
Sbjct: 208 KLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRT 267
Query: 748 GMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRKD-----LRLKQLESKKPIDSLDMV 802
G + + + L PMDI S E P + R ++ L L +P +
Sbjct: 268 GGKRKEILSALYSPMDIQVLSQERQP---FFHTRCEEDNGGCSHLCLLSPSEPFYTCACP 324
Query: 803 IPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIV--DSNLIWPAGLAFD 860
V+ + + + + + R L+ T IV ++ + +D
Sbjct: 325 TGVQLQDNGRTCKAGAEEVLLL---ARRTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYD 381
Query: 861 WITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCI 920
+ +YWTD I + DGS L I+ P I V+ +YW+D G I
Sbjct: 382 PLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDR-I 440
Query: 921 ERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTD-GGNKTIEYANLDGTGRTKLIE- 978
E ++G +RK L+ + P +AL V +YWTD G N IE ANLDG R L+
Sbjct: 441 EVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNA 500
Query: 979 --NLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTL 1017
P+ LDL +++W D T I+ N D G KRRTL
Sbjct: 501 SLGWPNGLALDLQEGKLYWGDAKTDKIEVINVD-GTKRRTL 540
Score = 245 bits (600), Expect = 1e-63
Identities = 173/556 (31%), Positives = 278/556 (50%), Gaps = 38/556 (6%)
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWL-TGDNYMSV 540
CS C T + RCGC G L D ++C L+F++R I ++ L T +N +++
Sbjct: 612 CSHLCFFTPHATRCGCPIGLELLSDMKTC--IVPEAFLVFTSRAAIHRISLETNNNDVAI 669
Query: 541 -VKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIH 599
+ G+ A ALD+ ++W++ +L+ I A MN ++ V+ +GL+ P G+AVDW+
Sbjct: 670 PLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMG 729
Query: 600 DLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERA 659
L+W D+GT R+EVA LDG R VLV DLD PR++A+ P ++WT+WG P+I RA
Sbjct: 730 KNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRA 789
Query: 660 DMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPH 719
MDG T++ D++ N LTIDY + ++YW D ++IE + G++ R V LPH
Sbjct: 790 FMDGTNCMTLV-DKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQE-RVVIADDLPH 847
Query: 720 PFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLY 779
PF LT + D IYWTDW+ SI +K +G + L+ MDI L+ +
Sbjct: 848 PFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDI-----------LVFH 896
Query: 780 ARRKDLRLKQLESKKPIDSLDMVIPVE---TIKSAVALDWDQKSNS---IFWTDVEKDTI 833
+ R+D + + L + IP S LD ++ S F +K I
Sbjct: 897 SSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAI 956
Query: 834 NRAYLNGSHQTTIV--DSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGS----MRT 887
+R + H ++ L + +D + IYW DG N I+ +K DG+ + +
Sbjct: 957 SRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQN-IKRAKDDGTQPFVLTS 1015
Query: 888 LLAWDHIDK-PRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLAL 946
L + D+ P D+ ++ ++W+ A+ I + G ++ G P + +
Sbjct: 1016 LSQGQNPDRQPHDLSIDIYSRTLFWT-CEATNTINVHRLSGEAMGVVLRGDRDKPRAIVV 1074
Query: 947 DLVHNRIYWTDGGNKT--IEYANLDGTGRTKLI-ENLPHPFGL--DLYGDEVFWTDWDTQ 1001
+ +Y+T+ ++ IE A LDGT R L L P L D ++FW D D +
Sbjct: 1075 NAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLK 1134
Query: 1002 SIQAANKDTGAKRRTL 1017
I++ + +GA R TL
Sbjct: 1135 RIESCDL-SGANRLTL 1149
Score = 235 bits (575), Expect = 1e-60
Identities = 111/274 (40%), Positives = 164/274 (59%), Gaps = 6/274 (2%)
Query: 477 EQDPVCSQTC--SNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTG 534
E + CS C S + + C C TG L+ + R+CK G LL + R +R++ L
Sbjct: 301 EDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCK-AGAEEVLLLARRTDLRRISLDT 359
Query: 535 DNYMSVV---KGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPA 591
++ +V + +A+A+DY + V+W+++ +R IR A ++ ++ + P
Sbjct: 360 PDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPD 419
Query: 592 GVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWG 651
G+AVDW+ L+WTD+GT R+EV L+G+ R +LV+ DLD+PRAIA+HP L++WTDWG
Sbjct: 420 GIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWG 479
Query: 652 PNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRK 711
NPKIE A++DG +R+ ++ + WPNGL +D E K+YW DAK IE DG RR
Sbjct: 480 ENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRT 539
Query: 712 VTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNK 745
+ LPH F TL D IYWTDW +SI V+K
Sbjct: 540 LLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHK 573
Score = 134 bits (324), Expect = 3e-30
Identities = 83/286 (29%), Positives = 129/286 (45%), Gaps = 11/286 (3%)
Query: 471 IDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQV 530
+++CM+ C Q C G RCGC + Y L P R+C P + LLFS + I ++
Sbjct: 903 LNDCMHNNGQ-CGQLCLAIPGGHRCGCASHYTLDPSSRNCSPP--TTFLLFSQKSAISRM 959
Query: 531 WLTGDNYMSVV---KGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKN-MSDVIRWG 586
+ ++ GL N A+DY K ++W + + R T+ + + G
Sbjct: 960 IPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQG 1019
Query: 587 LET---PAGVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDA 643
P +++D LFWT T + V L G V++ D DKPRAI V+
Sbjct: 1020 QNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERG 1079
Query: 644 LVFWTDWGPNP-KIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERA 702
+++T+ KIERA +DG +R+ + + P L +D T K++W DA IE
Sbjct: 1080 YLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESC 1139
Query: 703 AFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTG 748
G +R + + P LT+ +YW D + I V K TG
Sbjct: 1140 DLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTG 1185
Score = 102 bits (244), Expect = 1e-20
Identities = 47/123 (38%), Positives = 71/123 (57%), Gaps = 10/123 (8%)
Query: 263 CAEIDFECKNTK--CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPER 320
C+ F C + C+P ++CDG +C D +DE+ CP+ C+A +F C G+C+ R
Sbjct: 1259 CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV----CSAAQFPCARGQCVDLR 1314
Query: 321 WRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC 380
RCD E DC D DE +C ++I C +++ CA +CVL CD DC +G DE+ C
Sbjct: 1315 LRCDGEADCQDRSDEADC--DAI--CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
Query: 381 EVS 383
E++
Sbjct: 1371 EIT 1373
Score = 85.8 bits (203), Expect = 1e-15
Identities = 48/146 (32%), Positives = 64/146 (43%), Gaps = 16/146 (10%)
Query: 301 PGSCNAGEFKCNDGK--CIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRC 358
P +C+ +F C G+ CIP WRCD +C D DE C CS ++ CA +C
Sbjct: 1256 PPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV-----CSAAQFPCARGQC 1310
Query: 359 VLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDC 418
V CDG DC + DE +C+ C +Q+ C A CV K CD DC
Sbjct: 1311 VDLRLRCDGEADCQDRSDEADCDAICLPNQFRC---------ASGQCVLIKQQCDSFPDC 1361
Query: 419 PRGDDEERCPLKRKCSAEEKCEKLCI 444
G DE C + + S + I
Sbjct: 1362 IDGSDELMCEITKPPSDDSPAHSSAI 1387
Score = 38.3 bits (85), Expect = 0.25
Identities = 18/72 (25%), Positives = 31/72 (43%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCM 498
C +CI DG C+CP+ +L ++ +C + C +Q + G++RC
Sbjct: 1224 CSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGF 1283
Query: 499 TGYILRPDERSC 510
+ DE C
Sbjct: 1284 PECDDQSDEEGC 1295
Score = 36.3 bits (80), Expect = 1.00
Identities = 13/26 (50%), Positives = 17/26 (65%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVV 198
C+ L CDG+ DC D SDE +CD +
Sbjct: 1310 CVDLRLRCDGEADCQDRSDEADCDAI 1335
Score = 33.9 bits (74), Expect = 5.3
Identities = 31/117 (26%), Positives = 45/117 (38%), Gaps = 6/117 (5%)
Query: 101 DDGPLNEGTEDDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDE 160
D P + D+ GC C F C C+ + R C
Sbjct: 1281 DGFPECDDQSDEEGCPV-CSAAQFPCARG-QCVDLRLRCDGEADCQDRSDEADCDAICLP 1338
Query: 161 HENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVI 217
++ R C S C+ ++ CD DC D SDE+ C++ K A++S IG VI
Sbjct: 1339 NQFR--CASGQ-CVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSA-IGPVI 1391
>AF064548-1|AAC36467.1| 1615|Homo sapiens low-density lipoprotein
receptor-related protein 5 protein.
Length = 1615
Score = 780 bits (1928), Expect = 0.0
Identities = 395/923 (42%), Positives = 552/923 (59%), Gaps = 49/923 (5%)
Query: 776 LLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINR 835
LLL+A R+D+RL K L+ I V ++ A A+D+ +++WTDV ++ I +
Sbjct: 34 LLLFANRRDVRLVDAGGVK----LESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQ 89
Query: 836 AYLN--GSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDH 893
YLN G+ +V S L+ P GLA DW+ K+YWTD TNRIEV+ +G+ R +L W
Sbjct: 90 TYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQD 149
Query: 894 IDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRI 953
+D+PR I ++P G MYW+DWG +P IERA MDG RK ++ + WPNGL +DL ++
Sbjct: 150 LDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKL 209
Query: 954 YWTDGGNKTIEYANLDGTGRTKLIE-NLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGA 1012
YW D I ANLDG+ R K++E +L HPF L L GD ++WTDW T+SI A NK TG
Sbjct: 210 YWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGG 269
Query: 1013 KRRTL-----------------------GCGKNNGGCSHLCLLKPGGR--SCACPIGIKL 1047
KR+ + C ++NGGCSHLCLL P +CACP G++L
Sbjct: 270 KRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQL 329
Query: 1048 NKDGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNALGVDVDHSTGLIYW 1107
+G+TC G L+ A R D+R ISLD P D+VL + +++A+ +D D G +YW
Sbjct: 330 QDNGRTCKAGAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYW 389
Query: 1108 TDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRN 1167
TD R I+RA G+ +T++ ++ DGI +D R +YWTD G + IEV L+G +
Sbjct: 390 TDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTS 449
Query: 1168 RKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLA 1227
RK+LV LD PRAIALH G M+W+DWG + KIE A++DG RRV+V+ + WPNGLA
Sbjct: 450 RKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLA 509
Query: 1228 IDRIEGRLYWNDAKILTIESSDFDGHDRRTVLSN-VPYPYGIVIVGQHIYWTDWKTKALH 1286
+D EG+LYW DAK IE + DG RRT+L + +P+ +G ++G IYWTDW+ +++
Sbjct: 510 LDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIE 569
Query: 1287 RADKTNASDPIVIRKNLEGLMDIRAIQSERVL-ENACGTDNGGCSHLCLRSPLGYTCACP 1345
R K AS ++I L LM ++A+ +V+ N C NGGCSHLC +P C CP
Sbjct: 570 RVHKVKASRDVII-DQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRCGCP 628
Query: 1346 TGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVD 1405
G+ + +D K C PE FL+F +R +I ISLE+ DV +P+ VK A+D
Sbjct: 629 IGL---ELLSDM--KTC-IVPEAFLVFTSRAAIHRISLETNNN-DVAIPLTGVKEASALD 681
Query: 1406 YHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHK 1465
+ I++TD+ L I M N S + ++ L+ P G+ VDW+ N+YW D
Sbjct: 682 FDVSNNHIYWTDVSLKTISRAFM-NGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTN 740
Query: 1466 VIEVARLDGSSRKVLI-TGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIV 1524
IEVARLDG R+VL+ L PR+LAL P KGY+YW++WG P I R+++DG+ +V
Sbjct: 741 RIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLV 800
Query: 1525 QVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQLVPDAKNPFGMTQFKDYIY 1584
+G N LTIDY ++RLYWTD + I++S++ GQ RV + D +PFG+TQ+ DYIY
Sbjct: 801 D-KVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIY 859
Query: 1585 WTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAVSADRQHGWNPCKESNGGCSHLCLF 1644
WTDW SI RADK +G+N TLI+ +L+ M+I + RQ G N C +NG C LCL
Sbjct: 860 WTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLA 919
Query: 1645 RGHEYICACPD----DPDHVECS 1663
+ C C DP CS
Sbjct: 920 IPGGHRCGCASHYTLDPSSRNCS 942
Score = 690 bits (1705), Expect = 0.0
Identities = 405/1172 (34%), Positives = 624/1172 (53%), Gaps = 61/1172 (5%)
Query: 527 IRQVWL--TGDNYMSVV-KGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVI 583
I+Q +L TG +VV GL + L + K ++W+++ I VA +N + +
Sbjct: 87 IKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLF 146
Query: 584 RWGLETPAGVAVDWIHDLLFWTDSG-TRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGD 642
L+ P +A+D H ++WTD G T R+E A +DGS R ++V +D+ P + + +
Sbjct: 147 WQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEE 206
Query: 643 ALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERA 702
++W D I RA++DG R+ V+ + P LT+ + +YW D + I
Sbjct: 207 QKLYWAD-AKLSFIHRANLDGSFRQKVVEGSLTHPFALTL--SGDTLYWTDWQTRSIHAC 263
Query: 703 AFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGI-------QTVH 755
+RK L P + + +HT+ + + + T
Sbjct: 264 NKRTGGKRKEILSALYSPMDIQVLSQERQ-PFFHTRCEEDNGGCSHLCLLSPSEPFYTCA 322
Query: 756 AGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALD 815
V + + R+C+ E++LL ARR DLR L++ D D+V+ V+ I+ A+A+D
Sbjct: 323 CPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTP---DFTDIVLQVDDIRHAIAID 379
Query: 816 WDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNR 875
+D ++WTD E I RAYL+GS T+V++ + P G+A DW+ +YWTD GT+R
Sbjct: 380 YDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDR 439
Query: 876 IEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIF 935
IEV++ +G+ R +L + +D+PR I ++P G+MYW+DWG +P IE A++DG R+ L+
Sbjct: 440 IEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVN 499
Query: 936 GQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN-LPHPFGLDLYGDEVF 994
+ WPNGLALDL ++YW D IE N+DGT R L+E+ LPH FG L GD ++
Sbjct: 500 ASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLLGDFIY 559
Query: 995 WTDWDTQSIQAANKDTGAK------------------RRTLG---CGKNNGGCSHLCLLK 1033
WTDW +SI+ +K ++ + +G C NGGCSHLC
Sbjct: 560 WTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFT 619
Query: 1034 PGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNA 1093
P C CPIG++L D KTC P +L+F R I ISL+ DV +PL +K A
Sbjct: 620 PHATRCGCPIGLELLSDMKTCIV-PEAFLVFTSRAAIHRISLETNNN-DVAIPLTGVKEA 677
Query: 1094 LGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDG 1153
+D D S IYWTD + I RA G+ VE V+ GL +G+ +D G+ +YW D
Sbjct: 678 SALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADT 737
Query: 1154 GRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRR 1213
G N IEVA LDG+ R+VLVW LD+PR++AL GY++W++WG +I RA MDG N
Sbjct: 738 GTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCM 797
Query: 1214 VIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLSNVPYPYGIVIVGQ 1273
+VD K+ N L ID + RLYW D IESS+ G +R + ++P+P+G+
Sbjct: 798 TLVD-KVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSD 856
Query: 1274 HIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQSERVLE-NACGTDNGGCSHL 1332
+IYWTDW ++ RADKT+ + +I+ +L+ +MDI S R N C +NG C L
Sbjct: 857 YIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQL 916
Query: 1333 CLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVT 1392
CL P G+ C C + T D + + C S P FL+F+ + +I+ + + D+
Sbjct: 917 CLAIPGGHRCGCASHY-----TLDPSSRNC-SPPTTFLLFSQKSAISRMIPDDQHSPDLI 970
Query: 1393 LPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLET---PNGLG 1449
LP+ ++N A+DY K I++ D N+ R+ + T +SQ P+ L
Sbjct: 971 LPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLS 1030
Query: 1450 VDWIANNIYWTDNEHKVIEVARLDGSSRKVLITG-LTEPRALALFPAKGYLYWSDWGEHP 1508
+D + ++WT I V RL G + V++ G +PRA+ + +GYLY+++ +
Sbjct: 1031 IDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRA 1090
Query: 1509 Y-IERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQLV 1567
IER+ LDG++R+++ L P L +D +L+W DA RI++ DL+G +R+ L
Sbjct: 1091 AKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTL- 1149
Query: 1568 PDAK--NPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAVS--AD 1623
DA P G+T ++YW D ++ I R +K TG T I+ + I AV +
Sbjct: 1150 EDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSL 1209
Query: 1624 RQHGWNPCKESNGGCSHLCLFRGH-EYICACP 1654
+ +PC NGGCSH+C+ +G C+CP
Sbjct: 1210 EEFSAHPCARDNGGCSHICIAKGDGTPRCSCP 1241
Score = 454 bits (1119), Expect = e-126
Identities = 279/882 (31%), Positives = 443/882 (50%), Gaps = 53/882 (6%)
Query: 527 IRQVWLTGDNYMSVVKG-LHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRW 585
IR+ +L G ++V +++ + + + ++W++ I V ++N + ++
Sbjct: 397 IRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSE 456
Query: 586 GLETPAGVAVDWIHDLLFWTDSGTR-RVEVATLDGSKRAVLVANDLDKPRAIAVHPGDAL 644
L+ P +A+ + L++WTD G ++E A LDG +R VLV L P +A+ +
Sbjct: 457 DLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGK 516
Query: 645 VFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAF 704
++W D KIE ++DG KR+T++ D++ G T+ IYW D + IER
Sbjct: 517 LYWGD-AKTDKIEVINVDGTKRRTLLEDKLPHIFGFTL--LGDFIYWTDWQRRSIERV-H 572
Query: 705 DGRDRRKVTTKGLPHPFALTLFDDA-IYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMD 763
+ R V LP L + A + T+ + G + ++
Sbjct: 573 KVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRCGCPIGLE 632
Query: 764 IHS--RSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSN 821
+ S ++C PE L++ R + LE+ ++ D+ IP+ +K A ALD+D +N
Sbjct: 633 LLSDMKTCI-VPEAFLVFTSRAAIHRISLET----NNNDVAIPLTGVKEASALDFDVSNN 687
Query: 822 SIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKS 881
I+WTDV TI+RA++NGS +V+ L +P G+A DW+ +YW D GTNRIEV++
Sbjct: 688 HIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARL 747
Query: 882 DGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWP 941
DG R +L W +D PR + ++P G +YW++WG P I RA MDG N L+ ++
Sbjct: 748 DGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLV-DKVGRA 806
Query: 942 NGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIENLPHPFGLDLYGDEVFWTDWDTQ 1001
N L +D R+YWTD IE +N+ G R + ++LPHPFGL Y D ++WTDW+
Sbjct: 807 NDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLH 866
Query: 1002 SIQAANKDTGAKRRTL----------------------GCGKNNGGCSHLCLLKPGGRSC 1039
SI+ A+K +G R + C NNG C LCL PGG C
Sbjct: 867 SIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRC 926
Query: 1040 ACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNALGVDVD 1099
C L+ + C+ P +L+F+ + I + D + D++LPL L+N +D D
Sbjct: 927 GCASHYTLDPSSRNCSP-PTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYD 985
Query: 1100 HSTGLIYWTDTGQRKIQRATRLGTH--VETVIGNGLHT---ADGIVIDSTGRKIYWTDGG 1154
IYW D G++ I+RA GT V T + G + + ID R ++WT
Sbjct: 986 PLDKFIYWVD-GRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEA 1044
Query: 1155 RNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDW-GTSAKIERADMDGNNRR 1213
N+I V L G V++ D PRAI ++ E GY+++++ +AKIERA +DG R
Sbjct: 1045 TNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTERE 1104
Query: 1214 VIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVL-SNVPYPYGIVIVG 1272
V+ + P L +D G+L+W DA + IES D G +R T+ +N+ P G+ I+G
Sbjct: 1105 VLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILG 1164
Query: 1273 QHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQS---ERVLENACGTDNGGC 1329
+H+YW D + + + R +KT I+ + L I A++ E + C DNGGC
Sbjct: 1165 KHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGC 1224
Query: 1330 SHLCLRSPLGY-TCACPTGMP-FEKSTTDQTPKKCKSHPEEF 1369
SH+C+ G C+CP + + T P C P++F
Sbjct: 1225 SHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCS--PDQF 1264
Score = 316 bits (776), Expect = 5e-85
Identities = 194/521 (37%), Positives = 268/521 (51%), Gaps = 23/521 (4%)
Query: 512 PTGESPTLLFSNRIGIRQVWLTGDNYMS--VVKGLHNAVALDYHYEKKLVFWSENNLRVI 569
P SP LLF+NR +R V G S VV GL +A A+D+ + K V+W++ + I
Sbjct: 28 PAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAI 87
Query: 570 RVAQMNTKN--MSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVA 627
+ +N + +V+ GL +P G+A DW+ L+WTDS T R+EVA L+G+ R VL
Sbjct: 88 KQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFW 147
Query: 628 NDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTES 687
DLD+PRAIA+ P ++WTDWG P+IERA MDG RK ++ +I+WPNGLTID E
Sbjct: 148 QDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQ 207
Query: 688 KIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNT 747
K+YWADAK I RA DG R+KV L HPFALTL D +YWTDW T+SI NK T
Sbjct: 208 KLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRT 267
Query: 748 GMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRKD-----LRLKQLESKKPIDSLDMV 802
G + + + L PMDI S E P + R ++ L L +P +
Sbjct: 268 GGKRKEILSALYSPMDIQVLSQERQP---FFHTRCEEDNGGCSHLCLLSPSEPFYTCACP 324
Query: 803 IPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIV--DSNLIWPAGLAFD 860
V+ + + + + + R L+ T IV ++ + +D
Sbjct: 325 TGVQLQDNGRTCKAGAEEVLLL---ARRTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYD 381
Query: 861 WITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCI 920
+ +YWTD I + DGS L I+ P I V+ +YW+D G I
Sbjct: 382 PLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDR-I 440
Query: 921 ERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTD-GGNKTIEYANLDGTGRTKLIE- 978
E ++G +RK L+ + P +AL V +YWTD G N IE ANLDG R L+
Sbjct: 441 EVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNA 500
Query: 979 --NLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTL 1017
P+ LDL +++W D T I+ N D G KRRTL
Sbjct: 501 SLGWPNGLALDLQEGKLYWGDAKTDKIEVINVD-GTKRRTL 540
Score = 245 bits (600), Expect = 1e-63
Identities = 173/556 (31%), Positives = 278/556 (50%), Gaps = 38/556 (6%)
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWL-TGDNYMSV 540
CS C T + RCGC G L D ++C L+F++R I ++ L T +N +++
Sbjct: 612 CSHLCFFTPHATRCGCPIGLELLSDMKTC--IVPEAFLVFTSRAAIHRISLETNNNDVAI 669
Query: 541 -VKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIH 599
+ G+ A ALD+ ++W++ +L+ I A MN ++ V+ +GL+ P G+AVDW+
Sbjct: 670 PLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMG 729
Query: 600 DLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERA 659
L+W D+GT R+EVA LDG R VLV DLD PR++A+ P ++WT+WG P+I RA
Sbjct: 730 KNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRA 789
Query: 660 DMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPH 719
MDG T++ D++ N LTIDY + ++YW D ++IE + G++ R V LPH
Sbjct: 790 FMDGTNCMTLV-DKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQE-RVVIADDLPH 847
Query: 720 PFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLY 779
PF LT + D IYWTDW+ SI +K +G + L+ MDI L+ +
Sbjct: 848 PFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDI-----------LVFH 896
Query: 780 ARRKDLRLKQLESKKPIDSLDMVIPVE---TIKSAVALDWDQKSNS---IFWTDVEKDTI 833
+ R+D + + L + IP S LD ++ S F +K I
Sbjct: 897 SSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAI 956
Query: 834 NRAYLNGSHQTTIV--DSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGS----MRT 887
+R + H ++ L + +D + IYW DG N I+ +K DG+ + +
Sbjct: 957 SRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQN-IKRAKDDGTQPFVLTS 1015
Query: 888 LLAWDHIDK-PRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLAL 946
L + D+ P D+ ++ ++W+ A+ I + G ++ G P + +
Sbjct: 1016 LSQGQNPDRQPHDLSIDIYSRTLFWT-CEATNTINVHRLSGEAMGVVLRGDRDKPRAIVV 1074
Query: 947 DLVHNRIYWTDGGNKT--IEYANLDGTGRTKLI-ENLPHPFGL--DLYGDEVFWTDWDTQ 1001
+ +Y+T+ ++ IE A LDGT R L L P L D ++FW D D +
Sbjct: 1075 NAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLK 1134
Query: 1002 SIQAANKDTGAKRRTL 1017
I++ + +GA R TL
Sbjct: 1135 RIESCDL-SGANRLTL 1149
Score = 235 bits (575), Expect = 1e-60
Identities = 111/274 (40%), Positives = 164/274 (59%), Gaps = 6/274 (2%)
Query: 477 EQDPVCSQTC--SNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTG 534
E + CS C S + + C C TG L+ + R+CK G LL + R +R++ L
Sbjct: 301 EDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCK-AGAEEVLLLARRTDLRRISLDT 359
Query: 535 DNYMSVV---KGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPA 591
++ +V + +A+A+DY + V+W+++ +R IR A ++ ++ + P
Sbjct: 360 PDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPD 419
Query: 592 GVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWG 651
G+AVDW+ L+WTD+GT R+EV L+G+ R +LV+ DLD+PRAIA+HP L++WTDWG
Sbjct: 420 GIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWG 479
Query: 652 PNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRK 711
NPKIE A++DG +R+ ++ + WPNGL +D E K+YW DAK IE DG RR
Sbjct: 480 ENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRT 539
Query: 712 VTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNK 745
+ LPH F TL D IYWTDW +SI V+K
Sbjct: 540 LLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHK 573
Score = 134 bits (324), Expect = 3e-30
Identities = 83/286 (29%), Positives = 129/286 (45%), Gaps = 11/286 (3%)
Query: 471 IDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQV 530
+++CM+ C Q C G RCGC + Y L P R+C P + LLFS + I ++
Sbjct: 903 LNDCMHNNGQ-CGQLCLAIPGGHRCGCASHYTLDPSSRNCSPP--TTFLLFSQKSAISRM 959
Query: 531 WLTGDNYMSVV---KGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKN-MSDVIRWG 586
+ ++ GL N A+DY K ++W + + R T+ + + G
Sbjct: 960 IPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQG 1019
Query: 587 LET---PAGVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDA 643
P +++D LFWT T + V L G V++ D DKPRAI V+
Sbjct: 1020 QNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERG 1079
Query: 644 LVFWTDWGPNP-KIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERA 702
+++T+ KIERA +DG +R+ + + P L +D T K++W DA IE
Sbjct: 1080 YLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESC 1139
Query: 703 AFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTG 748
G +R + + P LT+ +YW D + I V K TG
Sbjct: 1140 DLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTG 1185
Score = 102 bits (244), Expect = 1e-20
Identities = 47/123 (38%), Positives = 71/123 (57%), Gaps = 10/123 (8%)
Query: 263 CAEIDFECKNTK--CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPER 320
C+ F C + C+P ++CDG +C D +DE+ CP+ C+A +F C G+C+ R
Sbjct: 1259 CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV----CSAAQFPCARGQCVDLR 1314
Query: 321 WRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC 380
RCD E DC D DE +C ++I C +++ CA +CVL CD DC +G DE+ C
Sbjct: 1315 LRCDGEADCQDRSDEADC--DAI--CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
Query: 381 EVS 383
E++
Sbjct: 1371 EIT 1373
Score = 85.8 bits (203), Expect = 1e-15
Identities = 48/146 (32%), Positives = 64/146 (43%), Gaps = 16/146 (10%)
Query: 301 PGSCNAGEFKCNDGK--CIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRC 358
P +C+ +F C G+ CIP WRCD +C D DE C CS ++ CA +C
Sbjct: 1256 PPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV-----CSAAQFPCARGQC 1310
Query: 359 VLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDC 418
V CDG DC + DE +C+ C +Q+ C A CV K CD DC
Sbjct: 1311 VDLRLRCDGEADCQDRSDEADCDAICLPNQFRC---------ASGQCVLIKQQCDSFPDC 1361
Query: 419 PRGDDEERCPLKRKCSAEEKCEKLCI 444
G DE C + + S + I
Sbjct: 1362 IDGSDELMCEITKPPSDDSPAHSSAI 1387
Score = 38.3 bits (85), Expect = 0.25
Identities = 18/72 (25%), Positives = 31/72 (43%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCM 498
C +CI DG C+CP+ +L ++ +C + C +Q + G++RC
Sbjct: 1224 CSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGF 1283
Query: 499 TGYILRPDERSC 510
+ DE C
Sbjct: 1284 PECDDQSDEEGC 1295
Score = 36.3 bits (80), Expect = 1.00
Identities = 13/26 (50%), Positives = 17/26 (65%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVV 198
C+ L CDG+ DC D SDE +CD +
Sbjct: 1310 CVDLRLRCDGEADCQDRSDEADCDAI 1335
Score = 33.9 bits (74), Expect = 5.3
Identities = 31/117 (26%), Positives = 45/117 (38%), Gaps = 6/117 (5%)
Query: 101 DDGPLNEGTEDDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDE 160
D P + D+ GC C F C C+ + R C
Sbjct: 1281 DGFPECDDQSDEEGCPV-CSAAQFPCARG-QCVDLRLRCDGEADCQDRSDEADCDAICLP 1338
Query: 161 HENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVI 217
++ R C S C+ ++ CD DC D SDE+ C++ K A++S IG VI
Sbjct: 1339 NQFR--CASGQ-CVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSA-IGPVI 1391
>AB017498-1|BAA33051.1| 1615|Homo sapiens Lipoprotein Receptor Related
Protein 5 protein.
Length = 1615
Score = 780 bits (1928), Expect = 0.0
Identities = 395/923 (42%), Positives = 552/923 (59%), Gaps = 49/923 (5%)
Query: 776 LLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINR 835
LLL+A R+D+RL K L+ I V ++ A A+D+ +++WTDV ++ I +
Sbjct: 34 LLLFANRRDVRLVDAGGVK----LESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQ 89
Query: 836 AYLN--GSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDH 893
YLN G+ +V S L+ P GLA DW+ K+YWTD TNRIEV+ +G+ R +L W
Sbjct: 90 TYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQD 149
Query: 894 IDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRI 953
+D+PR I ++P G MYW+DWG +P IERA MDG RK ++ + WPNGL +DL ++
Sbjct: 150 LDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKL 209
Query: 954 YWTDGGNKTIEYANLDGTGRTKLIE-NLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGA 1012
YW D I ANLDG+ R K++E +L HPF L L GD ++WTDW T+SI A NK TG
Sbjct: 210 YWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGG 269
Query: 1013 KRRTL-----------------------GCGKNNGGCSHLCLLKPGGR--SCACPIGIKL 1047
KR+ + C ++NGGCSHLCLL P +CACP G++L
Sbjct: 270 KRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQL 329
Query: 1048 NKDGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNALGVDVDHSTGLIYW 1107
+G+TC G L+ A R D+R ISLD P D+VL + +++A+ +D D G +YW
Sbjct: 330 QDNGRTCKAGAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYW 389
Query: 1108 TDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRN 1167
TD R I+RA G+ +T++ ++ DGI +D R +YWTD G + IEV L+G +
Sbjct: 390 TDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTS 449
Query: 1168 RKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLA 1227
RK+LV LD PRAIALH G M+W+DWG + KIE A++DG RRV+V+ + WPNGLA
Sbjct: 450 RKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLA 509
Query: 1228 IDRIEGRLYWNDAKILTIESSDFDGHDRRTVLSN-VPYPYGIVIVGQHIYWTDWKTKALH 1286
+D EG+LYW DAK IE + DG RRT+L + +P+ +G ++G IYWTDW+ +++
Sbjct: 510 LDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIE 569
Query: 1287 RADKTNASDPIVIRKNLEGLMDIRAIQSERVL-ENACGTDNGGCSHLCLRSPLGYTCACP 1345
R K AS ++I L LM ++A+ +V+ N C NGGCSHLC +P C CP
Sbjct: 570 RVHKVKASRDVII-DQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRCGCP 628
Query: 1346 TGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVD 1405
G+ + +D K C PE FL+F +R +I ISLE+ DV +P+ VK A+D
Sbjct: 629 IGL---ELLSDM--KTC-IVPEAFLVFTSRAAIHRISLETNNN-DVAIPLTGVKEASALD 681
Query: 1406 YHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHK 1465
+ I++TD+ L I M N S + ++ L+ P G+ VDW+ N+YW D
Sbjct: 682 FDVSNNHIYWTDVSLKTISRAFM-NGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTN 740
Query: 1466 VIEVARLDGSSRKVLI-TGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIV 1524
IEVARLDG R+VL+ L PR+LAL P KGY+YW++WG P I R+++DG+ +V
Sbjct: 741 RIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLV 800
Query: 1525 QVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQLVPDAKNPFGMTQFKDYIY 1584
+G N LTIDY ++RLYWTD + I++S++ GQ RV + D +PFG+TQ+ DYIY
Sbjct: 801 D-KVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIY 859
Query: 1585 WTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAVSADRQHGWNPCKESNGGCSHLCLF 1644
WTDW SI RADK +G+N TLI+ +L+ M+I + RQ G N C +NG C LCL
Sbjct: 860 WTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLA 919
Query: 1645 RGHEYICACPD----DPDHVECS 1663
+ C C DP CS
Sbjct: 920 IPGGHRCGCASHYTLDPSSRNCS 942
Score = 690 bits (1705), Expect = 0.0
Identities = 405/1172 (34%), Positives = 624/1172 (53%), Gaps = 61/1172 (5%)
Query: 527 IRQVWL--TGDNYMSVV-KGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVI 583
I+Q +L TG +VV GL + L + K ++W+++ I VA +N + +
Sbjct: 87 IKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLF 146
Query: 584 RWGLETPAGVAVDWIHDLLFWTDSG-TRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGD 642
L+ P +A+D H ++WTD G T R+E A +DGS R ++V +D+ P + + +
Sbjct: 147 WQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEE 206
Query: 643 ALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERA 702
++W D I RA++DG R+ V+ + P LT+ + +YW D + I
Sbjct: 207 QKLYWAD-AKLSFIHRANLDGSFRQKVVEGSLTHPFALTL--SGDTLYWTDWQTRSIHAC 263
Query: 703 AFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGI-------QTVH 755
+RK L P + + +HT+ + + + T
Sbjct: 264 NKRTGGKRKEILSALYSPMDIQVLSQERQ-PFFHTRCEEDNGGCSHLCLLSPSEPFYTCA 322
Query: 756 AGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALD 815
V + + R+C+ E++LL ARR DLR L++ D D+V+ V+ I+ A+A+D
Sbjct: 323 CPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTP---DFTDIVLQVDDIRHAIAID 379
Query: 816 WDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNR 875
+D ++WTD E I RAYL+GS T+V++ + P G+A DW+ +YWTD GT+R
Sbjct: 380 YDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDR 439
Query: 876 IEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIF 935
IEV++ +G+ R +L + +D+PR I ++P G+MYW+DWG +P IE A++DG R+ L+
Sbjct: 440 IEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVN 499
Query: 936 GQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN-LPHPFGLDLYGDEVF 994
+ WPNGLALDL ++YW D IE N+DGT R L+E+ LPH FG L GD ++
Sbjct: 500 ASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLLGDFIY 559
Query: 995 WTDWDTQSIQAANKDTGAK------------------RRTLG---CGKNNGGCSHLCLLK 1033
WTDW +SI+ +K ++ + +G C NGGCSHLC
Sbjct: 560 WTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFT 619
Query: 1034 PGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNA 1093
P C CPIG++L D KTC P +L+F R I ISL+ DV +PL +K A
Sbjct: 620 PHATRCGCPIGLELLSDMKTCIV-PEAFLVFTSRAAIHRISLETNNN-DVAIPLTGVKEA 677
Query: 1094 LGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDG 1153
+D D S IYWTD + I RA G+ VE V+ GL +G+ +D G+ +YW D
Sbjct: 678 SALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADT 737
Query: 1154 GRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRR 1213
G N IEVA LDG+ R+VLVW LD+PR++AL GY++W++WG +I RA MDG N
Sbjct: 738 GTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCM 797
Query: 1214 VIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLSNVPYPYGIVIVGQ 1273
+VD K+ N L ID + RLYW D IESS+ G +R + ++P+P+G+
Sbjct: 798 TLVD-KVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSD 856
Query: 1274 HIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQSERVLE-NACGTDNGGCSHL 1332
+IYWTDW ++ RADKT+ + +I+ +L+ +MDI S R N C +NG C L
Sbjct: 857 YIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQL 916
Query: 1333 CLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVT 1392
CL P G+ C C + T D + + C S P FL+F+ + +I+ + + D+
Sbjct: 917 CLAIPGGHRCGCASHY-----TLDPSSRNC-SPPTTFLLFSQKSAISRMIPDDQHSPDLI 970
Query: 1393 LPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLET---PNGLG 1449
LP+ ++N A+DY K I++ D N+ R+ + T +SQ P+ L
Sbjct: 971 LPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLS 1030
Query: 1450 VDWIANNIYWTDNEHKVIEVARLDGSSRKVLITG-LTEPRALALFPAKGYLYWSDWGEHP 1508
+D + ++WT I V RL G + V++ G +PRA+ + +GYLY+++ +
Sbjct: 1031 IDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRA 1090
Query: 1509 Y-IERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQLV 1567
IER+ LDG++R+++ L P L +D +L+W DA RI++ DL+G +R+ L
Sbjct: 1091 AKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTL- 1149
Query: 1568 PDAK--NPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAVS--AD 1623
DA P G+T ++YW D ++ I R +K TG T I+ + I AV +
Sbjct: 1150 EDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSL 1209
Query: 1624 RQHGWNPCKESNGGCSHLCLFRGH-EYICACP 1654
+ +PC NGGCSH+C+ +G C+CP
Sbjct: 1210 EEFSAHPCARDNGGCSHICIAKGDGTPRCSCP 1241
Score = 454 bits (1119), Expect = e-126
Identities = 279/882 (31%), Positives = 443/882 (50%), Gaps = 53/882 (6%)
Query: 527 IRQVWLTGDNYMSVVKG-LHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRW 585
IR+ +L G ++V +++ + + + ++W++ I V ++N + ++
Sbjct: 397 IRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSE 456
Query: 586 GLETPAGVAVDWIHDLLFWTDSGTR-RVEVATLDGSKRAVLVANDLDKPRAIAVHPGDAL 644
L+ P +A+ + L++WTD G ++E A LDG +R VLV L P +A+ +
Sbjct: 457 DLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGK 516
Query: 645 VFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAF 704
++W D KIE ++DG KR+T++ D++ G T+ IYW D + IER
Sbjct: 517 LYWGD-AKTDKIEVINVDGTKRRTLLEDKLPHIFGFTL--LGDFIYWTDWQRRSIERV-H 572
Query: 705 DGRDRRKVTTKGLPHPFALTLFDDA-IYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMD 763
+ R V LP L + A + T+ + G + ++
Sbjct: 573 KVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRCGCPIGLE 632
Query: 764 IHS--RSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSN 821
+ S ++C PE L++ R + LE+ ++ D+ IP+ +K A ALD+D +N
Sbjct: 633 LLSDMKTCI-VPEAFLVFTSRAAIHRISLET----NNNDVAIPLTGVKEASALDFDVSNN 687
Query: 822 SIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKS 881
I+WTDV TI+RA++NGS +V+ L +P G+A DW+ +YW D GTNRIEV++
Sbjct: 688 HIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARL 747
Query: 882 DGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWP 941
DG R +L W +D PR + ++P G +YW++WG P I RA MDG N L+ ++
Sbjct: 748 DGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLV-DKVGRA 806
Query: 942 NGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIENLPHPFGLDLYGDEVFWTDWDTQ 1001
N L +D R+YWTD IE +N+ G R + ++LPHPFGL Y D ++WTDW+
Sbjct: 807 NDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLH 866
Query: 1002 SIQAANKDTGAKRRTL----------------------GCGKNNGGCSHLCLLKPGGRSC 1039
SI+ A+K +G R + C NNG C LCL PGG C
Sbjct: 867 SIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRC 926
Query: 1040 ACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNALGVDVD 1099
C L+ + C+ P +L+F+ + I + D + D++LPL L+N +D D
Sbjct: 927 GCASHYTLDPSSRNCSP-PTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYD 985
Query: 1100 HSTGLIYWTDTGQRKIQRATRLGTH--VETVIGNGLHT---ADGIVIDSTGRKIYWTDGG 1154
IYW D G++ I+RA GT V T + G + + ID R ++WT
Sbjct: 986 PLDKFIYWVD-GRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEA 1044
Query: 1155 RNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDW-GTSAKIERADMDGNNRR 1213
N+I V L G V++ D PRAI ++ E GY+++++ +AKIERA +DG R
Sbjct: 1045 TNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTERE 1104
Query: 1214 VIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVL-SNVPYPYGIVIVG 1272
V+ + P L +D G+L+W DA + IES D G +R T+ +N+ P G+ I+G
Sbjct: 1105 VLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILG 1164
Query: 1273 QHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQS---ERVLENACGTDNGGC 1329
+H+YW D + + + R +KT I+ + L I A++ E + C DNGGC
Sbjct: 1165 KHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGC 1224
Query: 1330 SHLCLRSPLGY-TCACPTGMP-FEKSTTDQTPKKCKSHPEEF 1369
SH+C+ G C+CP + + T P C P++F
Sbjct: 1225 SHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCS--PDQF 1264
Score = 316 bits (776), Expect = 5e-85
Identities = 194/521 (37%), Positives = 268/521 (51%), Gaps = 23/521 (4%)
Query: 512 PTGESPTLLFSNRIGIRQVWLTGDNYMS--VVKGLHNAVALDYHYEKKLVFWSENNLRVI 569
P SP LLF+NR +R V G S VV GL +A A+D+ + K V+W++ + I
Sbjct: 28 PAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAI 87
Query: 570 RVAQMNTKN--MSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVA 627
+ +N + +V+ GL +P G+A DW+ L+WTDS T R+EVA L+G+ R VL
Sbjct: 88 KQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFW 147
Query: 628 NDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTES 687
DLD+PRAIA+ P ++WTDWG P+IERA MDG RK ++ +I+WPNGLTID E
Sbjct: 148 QDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQ 207
Query: 688 KIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNT 747
K+YWADAK I RA DG R+KV L HPFALTL D +YWTDW T+SI NK T
Sbjct: 208 KLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRT 267
Query: 748 GMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRKD-----LRLKQLESKKPIDSLDMV 802
G + + + L PMDI S E P + R ++ L L +P +
Sbjct: 268 GGKRKEILSALYSPMDIQVLSQERQP---FFHTRCEEDNGGCSHLCLLSPSEPFYTCACP 324
Query: 803 IPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIV--DSNLIWPAGLAFD 860
V+ + + + + + R L+ T IV ++ + +D
Sbjct: 325 TGVQLQDNGRTCKAGAEEVLLL---ARRTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYD 381
Query: 861 WITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCI 920
+ +YWTD I + DGS L I+ P I V+ +YW+D G I
Sbjct: 382 PLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDR-I 440
Query: 921 ERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTD-GGNKTIEYANLDGTGRTKLIE- 978
E ++G +RK L+ + P +AL V +YWTD G N IE ANLDG R L+
Sbjct: 441 EVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNA 500
Query: 979 --NLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTL 1017
P+ LDL +++W D T I+ N D G KRRTL
Sbjct: 501 SLGWPNGLALDLQEGKLYWGDAKTDKIEVINVD-GTKRRTL 540
Score = 245 bits (600), Expect = 1e-63
Identities = 173/556 (31%), Positives = 278/556 (50%), Gaps = 38/556 (6%)
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWL-TGDNYMSV 540
CS C T + RCGC G L D ++C L+F++R I ++ L T +N +++
Sbjct: 612 CSHLCFFTPHATRCGCPIGLELLSDMKTC--IVPEAFLVFTSRAAIHRISLETNNNDVAI 669
Query: 541 -VKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIH 599
+ G+ A ALD+ ++W++ +L+ I A MN ++ V+ +GL+ P G+AVDW+
Sbjct: 670 PLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMG 729
Query: 600 DLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERA 659
L+W D+GT R+EVA LDG R VLV DLD PR++A+ P ++WT+WG P+I RA
Sbjct: 730 KNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRA 789
Query: 660 DMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPH 719
MDG T++ D++ N LTIDY + ++YW D ++IE + G++ R V LPH
Sbjct: 790 FMDGTNCMTLV-DKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQE-RVVIADDLPH 847
Query: 720 PFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLY 779
PF LT + D IYWTDW+ SI +K +G + L+ MDI L+ +
Sbjct: 848 PFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDI-----------LVFH 896
Query: 780 ARRKDLRLKQLESKKPIDSLDMVIPVE---TIKSAVALDWDQKSNS---IFWTDVEKDTI 833
+ R+D + + L + IP S LD ++ S F +K I
Sbjct: 897 SSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAI 956
Query: 834 NRAYLNGSHQTTIV--DSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGS----MRT 887
+R + H ++ L + +D + IYW DG N I+ +K DG+ + +
Sbjct: 957 SRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQN-IKRAKDDGTQPFVLTS 1015
Query: 888 LLAWDHIDK-PRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLAL 946
L + D+ P D+ ++ ++W+ A+ I + G ++ G P + +
Sbjct: 1016 LSQGQNPDRQPHDLSIDIYSRTLFWT-CEATNTINVHRLSGEAMGVVLRGDRDKPRAIVV 1074
Query: 947 DLVHNRIYWTDGGNKT--IEYANLDGTGRTKLI-ENLPHPFGL--DLYGDEVFWTDWDTQ 1001
+ +Y+T+ ++ IE A LDGT R L L P L D ++FW D D +
Sbjct: 1075 NAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLK 1134
Query: 1002 SIQAANKDTGAKRRTL 1017
I++ + +GA R TL
Sbjct: 1135 RIESCDL-SGANRLTL 1149
Score = 235 bits (575), Expect = 1e-60
Identities = 111/274 (40%), Positives = 164/274 (59%), Gaps = 6/274 (2%)
Query: 477 EQDPVCSQTC--SNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTG 534
E + CS C S + + C C TG L+ + R+CK G LL + R +R++ L
Sbjct: 301 EDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCK-AGAEEVLLLARRTDLRRISLDT 359
Query: 535 DNYMSVV---KGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPA 591
++ +V + +A+A+DY + V+W+++ +R IR A ++ ++ + P
Sbjct: 360 PDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPD 419
Query: 592 GVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWG 651
G+AVDW+ L+WTD+GT R+EV L+G+ R +LV+ DLD+PRAIA+HP L++WTDWG
Sbjct: 420 GIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWG 479
Query: 652 PNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRK 711
NPKIE A++DG +R+ ++ + WPNGL +D E K+YW DAK IE DG RR
Sbjct: 480 ENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRT 539
Query: 712 VTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNK 745
+ LPH F TL D IYWTDW +SI V+K
Sbjct: 540 LLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHK 573
Score = 134 bits (324), Expect = 3e-30
Identities = 83/286 (29%), Positives = 129/286 (45%), Gaps = 11/286 (3%)
Query: 471 IDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQV 530
+++CM+ C Q C G RCGC + Y L P R+C P + LLFS + I ++
Sbjct: 903 LNDCMHNNGQ-CGQLCLAIPGGHRCGCASHYTLDPSSRNCSPP--TTFLLFSQKSAISRM 959
Query: 531 WLTGDNYMSVV---KGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKN-MSDVIRWG 586
+ ++ GL N A+DY K ++W + + R T+ + + G
Sbjct: 960 IPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQG 1019
Query: 587 LET---PAGVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDA 643
P +++D LFWT T + V L G V++ D DKPRAI V+
Sbjct: 1020 QNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERG 1079
Query: 644 LVFWTDWGPNP-KIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERA 702
+++T+ KIERA +DG +R+ + + P L +D T K++W DA IE
Sbjct: 1080 YLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESC 1139
Query: 703 AFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTG 748
G +R + + P LT+ +YW D + I V K TG
Sbjct: 1140 DLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTG 1185
Score = 103 bits (246), Expect = 8e-21
Identities = 47/123 (38%), Positives = 72/123 (58%), Gaps = 10/123 (8%)
Query: 263 CAEIDFECKNTK--CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPER 320
C+ F C + C+P ++CDG +C D +DE+ CP+ C+A +F C G+C+ R
Sbjct: 1259 CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV----CSAAQFPCARGQCVDLR 1314
Query: 321 WRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC 380
RCD E DC D DE++C ++I C +++ CA +CVL CD DC +G DE+ C
Sbjct: 1315 LRCDGEADCQDRSDEVDC--DAI--CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
Query: 381 EVS 383
E++
Sbjct: 1371 EIT 1373
Score = 86.6 bits (205), Expect = 7e-16
Identities = 48/146 (32%), Positives = 65/146 (44%), Gaps = 16/146 (10%)
Query: 301 PGSCNAGEFKCNDGK--CIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRC 358
P +C+ +F C G+ CIP WRCD +C D DE C CS ++ CA +C
Sbjct: 1256 PPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV-----CSAAQFPCARGQC 1310
Query: 359 VLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDC 418
V CDG DC + DE++C+ C +Q+ C A CV K CD DC
Sbjct: 1311 VDLRLRCDGEADCQDRSDEVDCDAICLPNQFRC---------ASGQCVLIKQQCDSFPDC 1361
Query: 419 PRGDDEERCPLKRKCSAEEKCEKLCI 444
G DE C + + S + I
Sbjct: 1362 IDGSDELMCEITKPPSDDSPAHSSAI 1387
Score = 38.3 bits (85), Expect = 0.25
Identities = 18/72 (25%), Positives = 31/72 (43%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCM 498
C +CI DG C+CP+ +L ++ +C + C +Q + G++RC
Sbjct: 1224 CSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGF 1283
Query: 499 TGYILRPDERSC 510
+ DE C
Sbjct: 1284 PECDDQSDEEGC 1295
Score = 37.9 bits (84), Expect = 0.33
Identities = 13/26 (50%), Positives = 18/26 (69%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVV 198
C+ L CDG+ DC D SDE++CD +
Sbjct: 1310 CVDLRLRCDGEADCQDRSDEVDCDAI 1335
Score = 33.5 bits (73), Expect = 7.0
Identities = 31/117 (26%), Positives = 45/117 (38%), Gaps = 6/117 (5%)
Query: 101 DDGPLNEGTEDDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDE 160
D P + D+ GC C F C C+ + R C
Sbjct: 1281 DGFPECDDQSDEEGCPV-CSAAQFPCARG-QCVDLRLRCDGEADCQDRSDEVDCDAICLP 1338
Query: 161 HENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVI 217
++ R C S C+ ++ CD DC D SDE+ C++ K A++S IG VI
Sbjct: 1339 NQFR--CASGQ-CVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSA-IGPVI 1391
>BC126405-1|AAI26406.1| 1613|Homo sapiens low density lipoprotein
receptor-related protein 6 protein.
Length = 1613
Score = 776 bits (1918), Expect = 0.0
Identities = 395/910 (43%), Positives = 552/910 (60%), Gaps = 45/910 (4%)
Query: 776 LLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINR 835
LLLYA R+DLRL + K + I V ++ A A+D+ I+W+DV ++ I R
Sbjct: 22 LLLYANRRDLRLVDATNGKE----NATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKR 77
Query: 836 AYLNGSHQT-TIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHI 894
N + +V S L+ P GLA DW+ +K+YWTD TNRIEVS DGS+R +L W +
Sbjct: 78 TEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQEL 137
Query: 895 DKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIY 954
D+PR I ++P G MYW+DWG P IERA MDG +R +I ++ WPNGL LD ++Y
Sbjct: 138 DQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLY 197
Query: 955 WTDGGNKTIEYANLDGTGRTKLIE-NLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAK 1013
W D I +NLDGT R +++ +LPHPF L L+ D ++WTDW T SI A NK TG
Sbjct: 198 WADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEG 257
Query: 1014 RR-----------------------TLGCGKNNGGCSHLCLLKPGGR--SCACPIGIKLN 1048
R T CG +NGGCSHLCL+ P CACP G+KL
Sbjct: 258 LREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLL 317
Query: 1049 KDGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNALGVDVDHSTGLIYWT 1108
++GKTC DG L+ A R D+R ISLD P D+VL L +++A+ +D D G IYWT
Sbjct: 318 ENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWT 377
Query: 1109 DTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNR 1168
D R I+R+ G+ + V+ + DGI +D R +YWTD G + IEV L+G R
Sbjct: 378 DDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMR 437
Query: 1169 KVLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAI 1228
K+L+ L+ PRAI L GYM+W+DWG KIERA +DG++R V+V+ + WPNGLA+
Sbjct: 438 KILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLAL 497
Query: 1229 DRIEGRLYWNDAKILTIESSDFDGHDRRTVLSN-VPYPYGIVIVGQHIYWTDWKTKALHR 1287
D EG++YW DAK IE + DG RR ++ + +P+ +G ++G ++YWTDW+ +++ R
Sbjct: 498 DYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIER 557
Query: 1288 ADKTNASDPIVIRKNLEGLMDIRAIQSERVL-ENACGTDNGGCSHLCLRSPLGYTCACPT 1346
K +A ++I L LM ++A RV+ N C +NGGCSHLCL P G CACP
Sbjct: 558 VHKRSAEREVII-DQLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPI 616
Query: 1347 GMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDY 1406
G FE +D K C PE FL+F+ R I ISLE+ +V +P+ VK A+D+
Sbjct: 617 G--FE-LISDM--KTC-IVPEAFLLFSRRADIRRISLETNNN-NVAIPLTGVKEASALDF 669
Query: 1407 HWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKV 1466
I++TD+ L I M N S + ++ L+ P G+ VDW+ N+YW D
Sbjct: 670 DVTDNRIYWTDISLKTISRAFM-NGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNR 728
Query: 1467 IEVARLDGSSRKVLI-TGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQ 1525
IEV++LDG R+VL+ L PRALAL PA+G++YW++WG P I+R+ +DGS+R +V
Sbjct: 729 IEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVP 788
Query: 1526 VDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQLVPDAKNPFGMTQFKDYIYW 1585
++G NGLTIDY +RRLYWTD + I++S++ G +R + D +PFG+TQ++DYIYW
Sbjct: 789 -NVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYW 847
Query: 1586 TDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAVSADRQHGWNPCKESNGGCSHLCL-F 1644
TDW ++SI RA+K +G+N T+I+ +L+ M+I + RQ GWN C SNG CSHLCL
Sbjct: 848 TDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAV 907
Query: 1645 RGHEYICACP 1654
++C CP
Sbjct: 908 PVGGFVCGCP 917
Score = 714 bits (1764), Expect = 0.0
Identities = 405/1159 (34%), Positives = 646/1159 (55%), Gaps = 61/1159 (5%)
Query: 540 VVKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWG-LETPAGVAVDWI 598
VV GL + L + + ++W+++ I V+ ++ ++ V+ W L+ P +A+D
Sbjct: 90 VVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDG-SLRKVLFWQELDQPRAIALDPS 148
Query: 599 HDLLFWTDSG-TRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIE 657
++WTD G ++E A +DGS R +++ +++ P + + + ++W D N I
Sbjct: 149 SGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLN-FIH 207
Query: 658 RADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWAD-AKHHVIERAAFDGRDRRKVTTKG 716
++++DG R+ V+ + P LT+ E +YW D + H ++ + G R++ +
Sbjct: 208 KSNLDGTNRQAVVKGSLPHPFALTL--FEDILYWTDWSTHSILACNKYTGEGLREIHSDI 265
Query: 717 LP----HPFALTLFDDAIYWTDWHTKSISTVNKNTGMG-IQTVHAGLNVPMDIHSRSCEE 771
H F+ +A S + + + V + + ++C++
Sbjct: 266 FSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKD 325
Query: 772 TPEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKD 831
+LLL ARR DLR L++ D D+V+ +E I+ A+A+D+D I+WTD E
Sbjct: 326 GATELLLLARRTDLRRISLDTP---DFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVR 382
Query: 832 TINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAW 891
I R++++GS +V + + P G+A DW+ +YWTD GT+RIEV++ +G+MR +L
Sbjct: 383 AIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILIS 442
Query: 892 DHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHN 951
+ +++PR IV++P G MYW+DWG P IERA +DG +R L+ + WPNGLALD
Sbjct: 443 EDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEG 502
Query: 952 RIYWTDGGNKTIEYANLDGTGRTKLIEN-LPHPFGLDLYGDEVFWTDWDTQSIQAANKDT 1010
+IYW D IE N DGTGR L+E+ +PH FG L GD V+WTDW +SI+ +K +
Sbjct: 503 KIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRS 562
Query: 1011 GAKR------------------RTLG---CGKNNGGCSHLCLLKPGGRSCACPIGIKLNK 1049
+ R +G C + NGGCSHLCL +P G CACPIG +L
Sbjct: 563 AEREVIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELIS 622
Query: 1050 DGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNALGVDVDHSTGLIYWTD 1109
D KTC P +L+F+ R DIR ISL+ +V +PL +K A +D D + IYWTD
Sbjct: 623 DMKTCIV-PEAFLLFSRRADIRRISLETNNN-NVAIPLTGVKEASALDFDVTDNRIYWTD 680
Query: 1110 TGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRK 1169
+ I RA G+ +E V+ GL +G+ +D G+ +YW D G N IEV++LDG++R+
Sbjct: 681 ISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQ 740
Query: 1170 VLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAID 1229
VLVW LDSPRA+AL G+M+W++WG KI+RA MDG+ R +V N + NGL ID
Sbjct: 741 VLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPN-VGRANGLTID 799
Query: 1230 RIEGRLYWNDAKILTIESSDFDGHDRRTVLSNVPYPYGIVIVGQHIYWTDWKTKALHRAD 1289
+ RLYW D IESS+ G +R + ++P+P+G+ +IYWTDW +++ RA+
Sbjct: 800 YAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERAN 859
Query: 1290 KTNASDPIVIRKNLEGLMDIRAIQSERVLE-NACGTDNGGCSHLCLRSPLG-YTCACPTG 1347
KT+ + +I+ +L+ +MDI S R N C + NG CSHLCL P+G + C CP
Sbjct: 860 KTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAH 919
Query: 1348 MPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDYH 1407
+ + ++T C S P FL+F+ + +I + ++ + D+ LP+ ++N A+DY
Sbjct: 920 --YSLNADNRT---C-SAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYD 973
Query: 1408 WDLKMIFYTDLDLNVIRSINMTNMSESKTII-----SQKLET-PNGLGVDWIANNIYWTD 1461
K +++ D N+IR S+ T++ SQ LE P L +D + IYWT
Sbjct: 974 PLDKQLYWIDSRQNMIRKAQEDG-SQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTC 1032
Query: 1462 NEHKVIEVARLDGSSRKVLITGLTE-PRALALFPAKGYLYWSDWGEH-PYIERSYLDGSQ 1519
VI V RLDG S V++ G + PRA+ + P KGY+Y+++ E P IER+ LDG++
Sbjct: 1033 EATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTE 1092
Query: 1520 RQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQLV-PDAKNPFGMTQ 1578
R+++ L P L +D + +L+W D+ RI++SDL+G +R+ L + P G+T
Sbjct: 1093 REVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTV 1152
Query: 1579 FKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAVSA--DRQHGWNPCKESNG 1636
F++++YW D ++ I + D + T ++ + +I AV +++ +PC + NG
Sbjct: 1153 FENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNG 1212
Query: 1637 GCSHLCLFRGHEYI-CACP 1654
GCSH+CL +G C+CP
Sbjct: 1213 GCSHICLVKGDGTTRCSCP 1231
Score = 470 bits (1159), Expect = e-131
Identities = 288/883 (32%), Positives = 452/883 (51%), Gaps = 60/883 (6%)
Query: 533 TGDNYMSVVKGLH-NAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPA 591
+G ++ + H + +A+D+ + ++W++ I V ++N +I LE P
Sbjct: 392 SGSQFVVTAQIAHPDGIAVDW--VARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPR 449
Query: 592 GVAVDWIHDLLFWTDSGT-RRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDW 650
+ +D + ++WTD G ++E A LDGS R VLV L P +A+ + ++W D
Sbjct: 450 AIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGD- 508
Query: 651 GPNPKIERADMDGDKRKTVIYDEIFWPNGLTI--DYTESKIYWADAKHHVIERAAFDGRD 708
KIE + DG R+ ++ D+I G T+ DY +YW D + IER +
Sbjct: 509 AKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDY----VYWTDWQRRSIERVHKRSAE 564
Query: 709 RRKVTTKGLPHPFALTLFD-DAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHS- 766
R + + LP L + + ++ + + Q + + ++ S
Sbjct: 565 REVIIDQ-LPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISD 623
Query: 767 -RSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFW 825
++C PE LL++RR D+R LE+ ++ ++ IP+ +K A ALD+D N I+W
Sbjct: 624 MKTCI-VPEAFLLFSRRADIRRISLET----NNNNVAIPLTGVKEASALDFDVTDNRIYW 678
Query: 826 TDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSM 885
TD+ TI+RA++NGS +V+ L +P G+A DW+ +YW D GTNRIEVSK DG
Sbjct: 679 TDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQH 738
Query: 886 RTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLA 945
R +L W +D PR + ++P G MYW++WG P I+RA MDG R L+ + NGL
Sbjct: 739 RQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLV-PNVGRANGLT 797
Query: 946 LDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIENLPHPFGLDLYGDEVFWTDWDTQSIQA 1005
+D R+YWTD IE +N+ G R + ++LPHPFGL Y D ++WTDW +SI+
Sbjct: 798 IDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIER 857
Query: 1006 ANKDTGAKR-------------------RTLG---CGKNNGGCSHLCLLKP-GGRSCACP 1042
ANK +G R R G C +NG CSHLCL P GG C CP
Sbjct: 858 ANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCP 917
Query: 1043 IGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNALGVDVDHST 1102
LN D +TC+ P +L+F+ + I + +D D++LP+ L+N +D D
Sbjct: 918 AHYSLNADNRTCS-APTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLD 976
Query: 1103 GLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTAD------GIVIDSTGRKIYWTDGGRN 1156
+YW D+ Q I++A G+ TV+ + + + + + ID R IYWT N
Sbjct: 977 KQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATN 1036
Query: 1157 SIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGT-SAKIERADMDGNNRRVI 1215
I V LDGR+ V++ D PRA+ ++ E GYM++++ S KIERA +DG R V+
Sbjct: 1037 VINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVL 1096
Query: 1216 VDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVL-SNVPYPYGIVIVGQH 1274
+ + P LA+D G+L+W D+ + IESSD G +R + SN+ P G+ +
Sbjct: 1097 FFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENW 1156
Query: 1275 IYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQS---ERVLENACGTDNGGCSH 1331
+YW D + + + + D T ++ + L DI A++ + ++ C DNGGCSH
Sbjct: 1157 LYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSH 1216
Query: 1332 LCLRSPLGYT-CACPTGMP-FEKSTTDQTPKKCKSHPEEFLIF 1372
+CL G T C+CP + + + P C P++F F
Sbjct: 1217 ICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCS--PQQFTCF 1257
Score = 323 bits (794), Expect = 3e-87
Identities = 194/513 (37%), Positives = 275/513 (53%), Gaps = 16/513 (3%)
Query: 516 SPTLLFSNRIGIRQVWLTG--DNYMSVVKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQ 573
+P LL++NR +R V T +N VV GL +A A+D+ + L++WS+ + I+ +
Sbjct: 20 APLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTE 79
Query: 574 MN-TKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDK 632
N T+++ +V+ GL +P G+A DW+ + L+WTDS T R+EV+ LDGS R VL +LD+
Sbjct: 80 FNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQ 139
Query: 633 PRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWA 692
PRAIA+ P ++WTDWG PKIERA MDG R +I EI+WPNGLT+DY E K+YWA
Sbjct: 140 PRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWA 199
Query: 693 DAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQ 752
DAK + I ++ DG +R+ V LPHPFALTLF+D +YWTDW T SI NK TG G++
Sbjct: 200 DAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLR 259
Query: 753 TVHAGLNVPMDIHSRSCEETPEKLLLYARRKD--LRLKQLESKKPIDSLDMVIPVETIKS 810
+H+ + PMDIH+ S + P L + KP V+ +++
Sbjct: 260 EIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLEN 319
Query: 811 AVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIV--DSNLIWPAGLAFDWITDKIYW 868
D + + + + R L+ T IV ++ + +D + IYW
Sbjct: 320 GKTCK-DGATELLLL--ARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYW 376
Query: 869 TDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGG 928
TD I S DGS + I P I V+ +YW+D G IE ++G
Sbjct: 377 TDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDR-IEVTRLNGT 435
Query: 929 NRKKLIFGQMTWPNGLALDLVHNRIYWTDGGN-KTIEYANLDGTGRTKLIE-NLPHPFGL 986
RK LI + P + LD + +YWTD G IE A LDG+ R L+ +L P GL
Sbjct: 436 MRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGL 495
Query: 987 DLYGDE--VFWTDWDTQSIQAANKDTGAKRRTL 1017
L DE ++W D T I+ N D G RR L
Sbjct: 496 ALDYDEGKIYWGDAKTDKIEVMNTD-GTGRRVL 527
Score = 281 bits (688), Expect = 2e-74
Identities = 179/546 (32%), Positives = 278/546 (50%), Gaps = 39/546 (7%)
Query: 482 CSQTC--SNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMS 539
CS C S ++C C TG L + ++CK G + LL + R +R++ L ++
Sbjct: 293 CSHLCLMSPVKPFYQCACPTGVKLLENGKTCKD-GATELLLLARRTDLRRISLDTPDFTD 351
Query: 540 VV---KGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVD 596
+V + + +A+A+DY + ++W+++ +R IR + ++ V+ + P G+AVD
Sbjct: 352 IVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVD 411
Query: 597 WIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKI 656
W+ L+WTD+GT R+EV L+G+ R +L++ DL++PRAI + P ++WTDWG PKI
Sbjct: 412 WVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKI 471
Query: 657 ERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKG 716
ERA +DG R ++ + WPNGL +DY E KIYW DAK IE DG RR +
Sbjct: 472 ERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDK 531
Query: 717 LPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVH-----AGL---NVPMDIHSRS 768
+PH F TL D +YWTDW +SI V+K + + GL NV I S
Sbjct: 532 IPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRVIGSNP 591
Query: 769 CEETP---EKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFW 825
C E L LY R + L PI +++ ++T A + I
Sbjct: 592 CAEENGGCSHLCLY------RPQGLRCACPI-GFELISDMKTCIVPEAFLLFSRRADIRR 644
Query: 826 TDVEKDTINRAY-LNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGS 884
+E + N A L G + + +D FD ++IYWTD I + +GS
Sbjct: 645 ISLETNNNNVAIPLTGVKEASALD----------FDVTDNRIYWTDISLKTISRAFMNGS 694
Query: 885 MRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGL 944
+ +D P + V+ G +YW+D G + IE + +DG +R+ L++ + P L
Sbjct: 695 ALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNR-IEVSKLDGQHRQVLVWKDLDSPRAL 753
Query: 945 ALDLVHNRIYWTD-GGNKTIEYANLDGTGRTKLIENLPHPFGL--DLYGDEVFWTDWDTQ 1001
ALD +YWT+ GG I+ A +DG+ RT L+ N+ GL D ++WTD DT
Sbjct: 754 ALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTN 813
Query: 1002 SIQAAN 1007
I+++N
Sbjct: 814 LIESSN 819
Score = 261 bits (640), Expect = 1e-68
Identities = 175/563 (31%), Positives = 283/563 (50%), Gaps = 39/563 (6%)
Query: 477 EQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWL-TGD 535
E++ CS C RC C G+ L D ++C LLFS R IR++ L T +
Sbjct: 594 EENGGCSHLCLYRPQGLRCACPIGFELISDMKTC--IVPEAFLLFSRRADIRRISLETNN 651
Query: 536 NYMSV-VKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVA 594
N +++ + G+ A ALD+ ++W++ +L+ I A MN + V+ +GL+ P G+A
Sbjct: 652 NNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMA 711
Query: 595 VDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNP 654
VDW+ L+W D+GT R+EV+ LDG R VLV DLD PRA+A+ P + ++WT+WG P
Sbjct: 712 VDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKP 771
Query: 655 KIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTT 714
KI+RA MDG +R T++ + NGLTIDY + ++YW D ++IE + G + R+V
Sbjct: 772 KIDRAAMDGSERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLN-REVIA 829
Query: 715 KGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPE 774
LPHPF LT + D IYWTDW +SI NK +G + L+ MDI
Sbjct: 830 DDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDI---------- 879
Query: 775 KLLLYARRKDLRLKQLESKKPIDSLDMVIPVETI----KSAVALDWDQKSNS---IFWTD 827
L+ ++ R+ + S L + +PV + +L+ D ++ S F
Sbjct: 880 -LVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLF 938
Query: 828 VEKDTINRAYLNGSHQTTIV--DSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSM 885
+K INR ++ I+ +L + +D + ++YW D N I ++ DGS
Sbjct: 939 SQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQ 998
Query: 886 RTLLAWDHID------KPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMT 939
+ + +P D+ ++ +YW+ A+ I +DG + ++ G+
Sbjct: 999 GFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWT-CEATNVINVTRLDGRSVGVVLKGEQD 1057
Query: 940 WPNGLALDLVHNRIYWTDGGNKT--IEYANLDGTGRTKL-IENLPHPFGLDLYG--DEVF 994
P + ++ +Y+T+ ++ IE A LDGT R L L P L L ++F
Sbjct: 1058 RPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLF 1117
Query: 995 WTDWDTQSIQAANKDTGAKRRTL 1017
W D D + I++++ +GA R L
Sbjct: 1118 WADSDLRRIESSDL-SGANRIVL 1139
Score = 197 bits (480), Expect = 3e-49
Identities = 158/602 (26%), Positives = 290/602 (48%), Gaps = 35/602 (5%)
Query: 435 AEEK--CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDE-CMYEQDPVCSQTCSNTVG 491
AEE C LC+ G CACP+GF L D +C + ++ + + T
Sbjct: 593 AEENGGCSHLCLYRPQG-LRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNN 651
Query: 492 SFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQV---WLTGDNYMSVVK-GLHNA 547
+ +TG E S + ++ I ++ + ++ G VV+ GL
Sbjct: 652 NNVAIPLTGV----KEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYP 707
Query: 548 VALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDS 607
+ + K ++W++ I V++++ ++ ++ L++P +A+D ++WT+
Sbjct: 708 EGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEW 767
Query: 608 GTR-RVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKR 666
G + +++ A +DGS+R LV N + + + + ++WTD N IE ++M G R
Sbjct: 768 GGKPKIDRAAMDGSERTTLVPN-VGRANGLTIDYAKRRLYWTDLDTN-LIESSNMLGLNR 825
Query: 667 KTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLF 726
+ VI D++ P GLT Y + IYW D IERA R + L + + +F
Sbjct: 826 E-VIADDLPHPFGLT-QY-QDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVF 882
Query: 727 DDAIY--WTDWHTKS--ISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARR 782
+ W + + + S + +G + ++ +R+C P LL++++
Sbjct: 883 HSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCS-APTTFLLFSQK 941
Query: 783 KDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSH 842
+ ++ ++ S D+++P+ ++++ A+D+D ++W D ++ I +A +GS
Sbjct: 942 SAINRMVIDEQQ---SPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQ 998
Query: 843 QTTIVDSNL------IWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDK 896
T+V S++ I P L+ D + IYWT TN I V++ DG ++ D+
Sbjct: 999 GFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDR 1058
Query: 897 PRDIVVNPEGGVMYWSD-WGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYW 955
PR +VVNPE G MY+++ SP IERA +DG R+ L F ++ P LALD +++W
Sbjct: 1059 PRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFW 1118
Query: 956 TDGGNKTIEYANLDGTGRTKLIE-NLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAKR 1014
D + IE ++L G R L + N+ P GL ++ + ++W D Q I+ + TG +
Sbjct: 1119 ADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDM-TGREG 1177
Query: 1015 RT 1016
RT
Sbjct: 1178 RT 1179
Score = 137 bits (332), Expect = 3e-31
Identities = 86/296 (29%), Positives = 145/296 (48%), Gaps = 13/296 (4%)
Query: 482 CSQTC-SNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSV 540
CS C + VG F CGC Y L D R+C + + LLFS + I ++ + +
Sbjct: 900 CSHLCLAVPVGGFVCGCPAHYSLNADNRTC--SAPTTFLLFSQKSAINRMVIDEQQSPDI 957
Query: 541 VKGLH---NAVALDYHYEKKLVFWSENNLRVIRVAQMN-----TKNMSDVIRWGLET-PA 591
+ +H N A+DY K ++W ++ +IR AQ + T +S V LE P
Sbjct: 958 ILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPY 1017
Query: 592 GVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWG 651
+++D ++WT T + V LDG V++ + D+PRA+ V+P +++T+
Sbjct: 1018 DLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQ 1077
Query: 652 P-NPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRR 710
+PKIERA +DG +R+ + + + P L +D K++WAD+ IE + G +R
Sbjct: 1078 ERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRI 1137
Query: 711 KVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHS 766
+ + P LT+F++ +YW D + I ++ G V A + DIH+
Sbjct: 1138 VLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHA 1193
Score = 90.2 bits (214), Expect = 6e-17
Identities = 41/120 (34%), Positives = 68/120 (56%), Gaps = 10/120 (8%)
Query: 263 CAEIDFECKNTK--CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPER 320
C+ F C + C+P ++CDG +C D +DE +CP+ C+ +F+C G+CI
Sbjct: 1249 CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV----CSESQFQCASGQCIDGA 1304
Query: 321 WRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC 380
RC+ + +C D DE NC+ C +D++ CA+ +C+ K CD DC++ DE++C
Sbjct: 1305 LRCNGDANCQDKSDEKNCEV----LCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
Score = 89.0 bits (211), Expect = 1e-16
Identities = 50/137 (36%), Positives = 65/137 (47%), Gaps = 17/137 (12%)
Query: 293 DEDSCPMVPGSCNAGEFKCNDGK--CIPERWRCDNERDCADGGDELNCKPNSIRNCSLDE 350
DE SC P +C+ +F C G+ CIP WRCD +C D DELNC CS +
Sbjct: 1239 DELSCGEPP-TCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV-----CSESQ 1292
Query: 351 YTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKH 410
+ CA +C+ C+G +C + DE NCEV C DQ+ C A C+ +
Sbjct: 1293 FQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRC---------ANGQCIGKHK 1343
Query: 411 VCDGMKDCPRGDDEERC 427
CD DC DE C
Sbjct: 1344 KCDHNVDCSDKSDELDC 1360
Score = 75.8 bits (178), Expect = 1e-12
Identities = 29/78 (37%), Positives = 50/78 (64%), Gaps = 3/78 (3%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C+E F+C + +C+ +C+GD +C D +DE +C ++ C +F+C +G+CI + +
Sbjct: 1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVL---CLIDQFRCANGQCIGKHKK 1344
Query: 323 CDNERDCADGGDELNCKP 340
CD+ DC+D DEL+C P
Sbjct: 1345 CDHNVDCSDKSDELDCYP 1362
Score = 44.4 bits (100), Expect = 0.004
Identities = 52/197 (26%), Positives = 78/197 (39%), Gaps = 22/197 (11%)
Query: 335 ELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDE--MNCEVSCEEDQYTCR 392
ELN + C+ D C+ C++K DG C+ + E+SC E TC
Sbjct: 1196 ELNLQEYRQHPCAQDNGGCS-HICLVKG---DGTTRCSCPMHLVLLQDELSCGEPP-TCS 1250
Query: 393 PQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE-KCEK-LCITTYDGH 450
PQ+ +C+ CDG +C DE CP+ CS + +C CI DG
Sbjct: 1251 PQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV---CSESQFQCASGQCI---DGA 1304
Query: 451 AACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSF-RCGCMTGYILRPDERS 509
C D+ +C + C+ +Q + C +G +C + DE
Sbjct: 1305 LRCNGDANCQDKSDEKNCEVL--CLIDQFRCANGQC---IGKHKKCDHNVDCSDKSDELD 1359
Query: 510 CKPTGESPTLLFSNRIG 526
C PT E P +N +G
Sbjct: 1360 CYPT-EEPAPQATNTVG 1375
Score = 40.3 bits (90), Expect = 0.061
Identities = 15/29 (51%), Positives = 18/29 (62%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTS 201
CI + W CDG +C D SDE+NC V S
Sbjct: 1263 CIPVAWRCDGFTECEDHSDELNCPVCSES 1291
>BC117136-1|AAI17137.1| 1613|Homo sapiens low density lipoprotein
receptor-related protein 6 protein.
Length = 1613
Score = 776 bits (1918), Expect = 0.0
Identities = 395/910 (43%), Positives = 552/910 (60%), Gaps = 45/910 (4%)
Query: 776 LLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINR 835
LLLYA R+DLRL + K + I V ++ A A+D+ I+W+DV ++ I R
Sbjct: 22 LLLYANRRDLRLVDATNGKE----NATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKR 77
Query: 836 AYLNGSHQT-TIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHI 894
N + +V S L+ P GLA DW+ +K+YWTD TNRIEVS DGS+R +L W +
Sbjct: 78 TEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQEL 137
Query: 895 DKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIY 954
D+PR I ++P G MYW+DWG P IERA MDG +R +I ++ WPNGL LD ++Y
Sbjct: 138 DQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLY 197
Query: 955 WTDGGNKTIEYANLDGTGRTKLIE-NLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAK 1013
W D I +NLDGT R +++ +LPHPF L L+ D ++WTDW T SI A NK TG
Sbjct: 198 WADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEG 257
Query: 1014 RR-----------------------TLGCGKNNGGCSHLCLLKPGGR--SCACPIGIKLN 1048
R T CG +NGGCSHLCL+ P CACP G+KL
Sbjct: 258 LREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLL 317
Query: 1049 KDGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNALGVDVDHSTGLIYWT 1108
++GKTC DG L+ A R D+R ISLD P D+VL L +++A+ +D D G IYWT
Sbjct: 318 ENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWT 377
Query: 1109 DTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNR 1168
D R I+R+ G+ + V+ + DGI +D R +YWTD G + IEV L+G R
Sbjct: 378 DDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMR 437
Query: 1169 KVLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAI 1228
K+L+ L+ PRAI L GYM+W+DWG KIERA +DG++R V+V+ + WPNGLA+
Sbjct: 438 KILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLAL 497
Query: 1229 DRIEGRLYWNDAKILTIESSDFDGHDRRTVLSN-VPYPYGIVIVGQHIYWTDWKTKALHR 1287
D EG++YW DAK IE + DG RR ++ + +P+ +G ++G ++YWTDW+ +++ R
Sbjct: 498 DYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIER 557
Query: 1288 ADKTNASDPIVIRKNLEGLMDIRAIQSERVL-ENACGTDNGGCSHLCLRSPLGYTCACPT 1346
K +A ++I L LM ++A RV+ N C +NGGCSHLCL P G CACP
Sbjct: 558 VHKRSAEREVII-DQLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPI 616
Query: 1347 GMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDY 1406
G FE +D K C PE FL+F+ R I ISLE+ +V +P+ VK A+D+
Sbjct: 617 G--FE-LISDM--KTC-IVPEAFLLFSRRADIRRISLETNNN-NVAIPLTGVKEASALDF 669
Query: 1407 HWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKV 1466
I++TD+ L I M N S + ++ L+ P G+ VDW+ N+YW D
Sbjct: 670 DVTDNRIYWTDISLKTISRAFM-NGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNR 728
Query: 1467 IEVARLDGSSRKVLI-TGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQ 1525
IEV++LDG R+VL+ L PRALAL PA+G++YW++WG P I+R+ +DGS+R +V
Sbjct: 729 IEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVP 788
Query: 1526 VDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQLVPDAKNPFGMTQFKDYIYW 1585
++G NGLTIDY +RRLYWTD + I++S++ G +R + D +PFG+TQ++DYIYW
Sbjct: 789 -NVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYW 847
Query: 1586 TDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAVSADRQHGWNPCKESNGGCSHLCL-F 1644
TDW ++SI RA+K +G+N T+I+ +L+ M+I + RQ GWN C SNG CSHLCL
Sbjct: 848 TDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAV 907
Query: 1645 RGHEYICACP 1654
++C CP
Sbjct: 908 PVGGFVCGCP 917
Score = 714 bits (1764), Expect = 0.0
Identities = 405/1159 (34%), Positives = 646/1159 (55%), Gaps = 61/1159 (5%)
Query: 540 VVKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWG-LETPAGVAVDWI 598
VV GL + L + + ++W+++ I V+ ++ ++ V+ W L+ P +A+D
Sbjct: 90 VVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDG-SLRKVLFWQELDQPRAIALDPS 148
Query: 599 HDLLFWTDSG-TRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIE 657
++WTD G ++E A +DGS R +++ +++ P + + + ++W D N I
Sbjct: 149 SGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLN-FIH 207
Query: 658 RADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWAD-AKHHVIERAAFDGRDRRKVTTKG 716
++++DG R+ V+ + P LT+ E +YW D + H ++ + G R++ +
Sbjct: 208 KSNLDGTNRQAVVKGSLPHPFALTL--FEDILYWTDWSTHSILACNKYTGEGLREIHSDI 265
Query: 717 LP----HPFALTLFDDAIYWTDWHTKSISTVNKNTGMG-IQTVHAGLNVPMDIHSRSCEE 771
H F+ +A S + + + V + + ++C++
Sbjct: 266 FSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKD 325
Query: 772 TPEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKD 831
+LLL ARR DLR L++ D D+V+ +E I+ A+A+D+D I+WTD E
Sbjct: 326 GATELLLLARRTDLRRISLDTP---DFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVR 382
Query: 832 TINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAW 891
I R++++GS +V + + P G+A DW+ +YWTD GT+RIEV++ +G+MR +L
Sbjct: 383 AIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILIS 442
Query: 892 DHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHN 951
+ +++PR IV++P G MYW+DWG P IERA +DG +R L+ + WPNGLALD
Sbjct: 443 EDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEG 502
Query: 952 RIYWTDGGNKTIEYANLDGTGRTKLIEN-LPHPFGLDLYGDEVFWTDWDTQSIQAANKDT 1010
+IYW D IE N DGTGR L+E+ +PH FG L GD V+WTDW +SI+ +K +
Sbjct: 503 KIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRS 562
Query: 1011 GAKR------------------RTLG---CGKNNGGCSHLCLLKPGGRSCACPIGIKLNK 1049
+ R +G C + NGGCSHLCL +P G CACPIG +L
Sbjct: 563 AEREVIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELIS 622
Query: 1050 DGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNALGVDVDHSTGLIYWTD 1109
D KTC P +L+F+ R DIR ISL+ +V +PL +K A +D D + IYWTD
Sbjct: 623 DMKTCIV-PEAFLLFSRRADIRRISLETNNN-NVAIPLTGVKEASALDFDVTDNRIYWTD 680
Query: 1110 TGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRK 1169
+ I RA G+ +E V+ GL +G+ +D G+ +YW D G N IEV++LDG++R+
Sbjct: 681 ISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQ 740
Query: 1170 VLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAID 1229
VLVW LDSPRA+AL G+M+W++WG KI+RA MDG+ R +V N + NGL ID
Sbjct: 741 VLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPN-VGRANGLTID 799
Query: 1230 RIEGRLYWNDAKILTIESSDFDGHDRRTVLSNVPYPYGIVIVGQHIYWTDWKTKALHRAD 1289
+ RLYW D IESS+ G +R + ++P+P+G+ +IYWTDW +++ RA+
Sbjct: 800 YAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERAN 859
Query: 1290 KTNASDPIVIRKNLEGLMDIRAIQSERVLE-NACGTDNGGCSHLCLRSPLG-YTCACPTG 1347
KT+ + +I+ +L+ +MDI S R N C + NG CSHLCL P+G + C CP
Sbjct: 860 KTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAH 919
Query: 1348 MPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDYH 1407
+ + ++T C S P FL+F+ + +I + ++ + D+ LP+ ++N A+DY
Sbjct: 920 --YSLNADNRT---C-SAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYD 973
Query: 1408 WDLKMIFYTDLDLNVIRSINMTNMSESKTII-----SQKLET-PNGLGVDWIANNIYWTD 1461
K +++ D N+IR S+ T++ SQ LE P L +D + IYWT
Sbjct: 974 PLDKQLYWIDSRQNMIRKAQEDG-SQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTC 1032
Query: 1462 NEHKVIEVARLDGSSRKVLITGLTE-PRALALFPAKGYLYWSDWGEH-PYIERSYLDGSQ 1519
VI V RLDG S V++ G + PRA+ + P KGY+Y+++ E P IER+ LDG++
Sbjct: 1033 EATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTE 1092
Query: 1520 RQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQLV-PDAKNPFGMTQ 1578
R+++ L P L +D + +L+W D+ RI++SDL+G +R+ L + P G+T
Sbjct: 1093 REVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTV 1152
Query: 1579 FKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAVSA--DRQHGWNPCKESNG 1636
F++++YW D ++ I + D + T ++ + +I AV +++ +PC + NG
Sbjct: 1153 FENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNG 1212
Query: 1637 GCSHLCLFRGHEYI-CACP 1654
GCSH+CL +G C+CP
Sbjct: 1213 GCSHICLVKGDGTTRCSCP 1231
Score = 470 bits (1159), Expect = e-131
Identities = 288/883 (32%), Positives = 452/883 (51%), Gaps = 60/883 (6%)
Query: 533 TGDNYMSVVKGLH-NAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPA 591
+G ++ + H + +A+D+ + ++W++ I V ++N +I LE P
Sbjct: 392 SGSQFVVTAQIAHPDGIAVDW--VARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPR 449
Query: 592 GVAVDWIHDLLFWTDSGT-RRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDW 650
+ +D + ++WTD G ++E A LDGS R VLV L P +A+ + ++W D
Sbjct: 450 AIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGD- 508
Query: 651 GPNPKIERADMDGDKRKTVIYDEIFWPNGLTI--DYTESKIYWADAKHHVIERAAFDGRD 708
KIE + DG R+ ++ D+I G T+ DY +YW D + IER +
Sbjct: 509 AKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDY----VYWTDWQRRSIERVHKRSAE 564
Query: 709 RRKVTTKGLPHPFALTLFD-DAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHS- 766
R + + LP L + + ++ + + Q + + ++ S
Sbjct: 565 REVIIDQ-LPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISD 623
Query: 767 -RSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFW 825
++C PE LL++RR D+R LE+ ++ ++ IP+ +K A ALD+D N I+W
Sbjct: 624 MKTCI-VPEAFLLFSRRADIRRISLET----NNNNVAIPLTGVKEASALDFDVTDNRIYW 678
Query: 826 TDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSM 885
TD+ TI+RA++NGS +V+ L +P G+A DW+ +YW D GTNRIEVSK DG
Sbjct: 679 TDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQH 738
Query: 886 RTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLA 945
R +L W +D PR + ++P G MYW++WG P I+RA MDG R L+ + NGL
Sbjct: 739 RQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLV-PNVGRANGLT 797
Query: 946 LDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIENLPHPFGLDLYGDEVFWTDWDTQSIQA 1005
+D R+YWTD IE +N+ G R + ++LPHPFGL Y D ++WTDW +SI+
Sbjct: 798 IDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIER 857
Query: 1006 ANKDTGAKR-------------------RTLG---CGKNNGGCSHLCLLKP-GGRSCACP 1042
ANK +G R R G C +NG CSHLCL P GG C CP
Sbjct: 858 ANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCP 917
Query: 1043 IGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNALGVDVDHST 1102
LN D +TC+ P +L+F+ + I + +D D++LP+ L+N +D D
Sbjct: 918 AHYSLNADNRTCS-APTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLD 976
Query: 1103 GLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTAD------GIVIDSTGRKIYWTDGGRN 1156
+YW D+ Q I++A G+ TV+ + + + + + ID R IYWT N
Sbjct: 977 KQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATN 1036
Query: 1157 SIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGT-SAKIERADMDGNNRRVI 1215
I V LDGR+ V++ D PRA+ ++ E GYM++++ S KIERA +DG R V+
Sbjct: 1037 VINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVL 1096
Query: 1216 VDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVL-SNVPYPYGIVIVGQH 1274
+ + P LA+D G+L+W D+ + IESSD G +R + SN+ P G+ +
Sbjct: 1097 FFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENW 1156
Query: 1275 IYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQS---ERVLENACGTDNGGCSH 1331
+YW D + + + + D T ++ + L DI A++ + ++ C DNGGCSH
Sbjct: 1157 LYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSH 1216
Query: 1332 LCLRSPLGYT-CACPTGMP-FEKSTTDQTPKKCKSHPEEFLIF 1372
+CL G T C+CP + + + P C P++F F
Sbjct: 1217 ICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCS--PQQFTCF 1257
Score = 323 bits (794), Expect = 3e-87
Identities = 194/513 (37%), Positives = 275/513 (53%), Gaps = 16/513 (3%)
Query: 516 SPTLLFSNRIGIRQVWLTG--DNYMSVVKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQ 573
+P LL++NR +R V T +N VV GL +A A+D+ + L++WS+ + I+ +
Sbjct: 20 APLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTE 79
Query: 574 MN-TKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDK 632
N T+++ +V+ GL +P G+A DW+ + L+WTDS T R+EV+ LDGS R VL +LD+
Sbjct: 80 FNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQ 139
Query: 633 PRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWA 692
PRAIA+ P ++WTDWG PKIERA MDG R +I EI+WPNGLT+DY E K+YWA
Sbjct: 140 PRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWA 199
Query: 693 DAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQ 752
DAK + I ++ DG +R+ V LPHPFALTLF+D +YWTDW T SI NK TG G++
Sbjct: 200 DAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLR 259
Query: 753 TVHAGLNVPMDIHSRSCEETPEKLLLYARRKD--LRLKQLESKKPIDSLDMVIPVETIKS 810
+H+ + PMDIH+ S + P L + KP V+ +++
Sbjct: 260 EIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLEN 319
Query: 811 AVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIV--DSNLIWPAGLAFDWITDKIYW 868
D + + + + R L+ T IV ++ + +D + IYW
Sbjct: 320 GKTCK-DGATELLLL--ARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYW 376
Query: 869 TDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGG 928
TD I S DGS + I P I V+ +YW+D G IE ++G
Sbjct: 377 TDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDR-IEVTRLNGT 435
Query: 929 NRKKLIFGQMTWPNGLALDLVHNRIYWTDGGN-KTIEYANLDGTGRTKLIE-NLPHPFGL 986
RK LI + P + LD + +YWTD G IE A LDG+ R L+ +L P GL
Sbjct: 436 MRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGL 495
Query: 987 DLYGDE--VFWTDWDTQSIQAANKDTGAKRRTL 1017
L DE ++W D T I+ N D G RR L
Sbjct: 496 ALDYDEGKIYWGDAKTDKIEVMNTD-GTGRRVL 527
Score = 281 bits (688), Expect = 2e-74
Identities = 179/546 (32%), Positives = 278/546 (50%), Gaps = 39/546 (7%)
Query: 482 CSQTC--SNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMS 539
CS C S ++C C TG L + ++CK G + LL + R +R++ L ++
Sbjct: 293 CSHLCLMSPVKPFYQCACPTGVKLLENGKTCKD-GATELLLLARRTDLRRISLDTPDFTD 351
Query: 540 VV---KGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVD 596
+V + + +A+A+DY + ++W+++ +R IR + ++ V+ + P G+AVD
Sbjct: 352 IVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVD 411
Query: 597 WIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKI 656
W+ L+WTD+GT R+EV L+G+ R +L++ DL++PRAI + P ++WTDWG PKI
Sbjct: 412 WVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKI 471
Query: 657 ERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKG 716
ERA +DG R ++ + WPNGL +DY E KIYW DAK IE DG RR +
Sbjct: 472 ERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDK 531
Query: 717 LPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVH-----AGL---NVPMDIHSRS 768
+PH F TL D +YWTDW +SI V+K + + GL NV I S
Sbjct: 532 IPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRVIGSNP 591
Query: 769 CEETP---EKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFW 825
C E L LY R + L PI +++ ++T A + I
Sbjct: 592 CAEENGGCSHLCLY------RPQGLRCACPI-GFELISDMKTCIVPEAFLLFSRRADIRR 644
Query: 826 TDVEKDTINRAY-LNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGS 884
+E + N A L G + + +D FD ++IYWTD I + +GS
Sbjct: 645 ISLETNNNNVAIPLTGVKEASALD----------FDVTDNRIYWTDISLKTISRAFMNGS 694
Query: 885 MRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGL 944
+ +D P + V+ G +YW+D G + IE + +DG +R+ L++ + P L
Sbjct: 695 ALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNR-IEVSKLDGQHRQVLVWKDLDSPRAL 753
Query: 945 ALDLVHNRIYWTD-GGNKTIEYANLDGTGRTKLIENLPHPFGL--DLYGDEVFWTDWDTQ 1001
ALD +YWT+ GG I+ A +DG+ RT L+ N+ GL D ++WTD DT
Sbjct: 754 ALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTN 813
Query: 1002 SIQAAN 1007
I+++N
Sbjct: 814 LIESSN 819
Score = 261 bits (640), Expect = 1e-68
Identities = 175/563 (31%), Positives = 283/563 (50%), Gaps = 39/563 (6%)
Query: 477 EQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWL-TGD 535
E++ CS C RC C G+ L D ++C LLFS R IR++ L T +
Sbjct: 594 EENGGCSHLCLYRPQGLRCACPIGFELISDMKTC--IVPEAFLLFSRRADIRRISLETNN 651
Query: 536 NYMSV-VKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVA 594
N +++ + G+ A ALD+ ++W++ +L+ I A MN + V+ +GL+ P G+A
Sbjct: 652 NNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMA 711
Query: 595 VDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNP 654
VDW+ L+W D+GT R+EV+ LDG R VLV DLD PRA+A+ P + ++WT+WG P
Sbjct: 712 VDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKP 771
Query: 655 KIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTT 714
KI+RA MDG +R T++ + NGLTIDY + ++YW D ++IE + G + R+V
Sbjct: 772 KIDRAAMDGSERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLN-REVIA 829
Query: 715 KGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPE 774
LPHPF LT + D IYWTDW +SI NK +G + L+ MDI
Sbjct: 830 DDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDI---------- 879
Query: 775 KLLLYARRKDLRLKQLESKKPIDSLDMVIPVETI----KSAVALDWDQKSNS---IFWTD 827
L+ ++ R+ + S L + +PV + +L+ D ++ S F
Sbjct: 880 -LVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLF 938
Query: 828 VEKDTINRAYLNGSHQTTIV--DSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSM 885
+K INR ++ I+ +L + +D + ++YW D N I ++ DGS
Sbjct: 939 SQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQ 998
Query: 886 RTLLAWDHID------KPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMT 939
+ + +P D+ ++ +YW+ A+ I +DG + ++ G+
Sbjct: 999 GFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWT-CEATNVINVTRLDGRSVGVVLKGEQD 1057
Query: 940 WPNGLALDLVHNRIYWTDGGNKT--IEYANLDGTGRTKL-IENLPHPFGLDLYG--DEVF 994
P + ++ +Y+T+ ++ IE A LDGT R L L P L L ++F
Sbjct: 1058 RPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLF 1117
Query: 995 WTDWDTQSIQAANKDTGAKRRTL 1017
W D D + I++++ +GA R L
Sbjct: 1118 WADSDLRRIESSDL-SGANRIVL 1139
Score = 197 bits (480), Expect = 3e-49
Identities = 158/602 (26%), Positives = 290/602 (48%), Gaps = 35/602 (5%)
Query: 435 AEEK--CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDE-CMYEQDPVCSQTCSNTVG 491
AEE C LC+ G CACP+GF L D +C + ++ + + T
Sbjct: 593 AEENGGCSHLCLYRPQG-LRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNN 651
Query: 492 SFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQV---WLTGDNYMSVVK-GLHNA 547
+ +TG E S + ++ I ++ + ++ G VV+ GL
Sbjct: 652 NNVAIPLTGV----KEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYP 707
Query: 548 VALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDS 607
+ + K ++W++ I V++++ ++ ++ L++P +A+D ++WT+
Sbjct: 708 EGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEW 767
Query: 608 GTR-RVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKR 666
G + +++ A +DGS+R LV N + + + + ++WTD N IE ++M G R
Sbjct: 768 GGKPKIDRAAMDGSERTTLVPN-VGRANGLTIDYAKRRLYWTDLDTN-LIESSNMLGLNR 825
Query: 667 KTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLF 726
+ VI D++ P GLT Y + IYW D IERA R + L + + +F
Sbjct: 826 E-VIADDLPHPFGLT-QY-QDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVF 882
Query: 727 DDAIY--WTDWHTKS--ISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARR 782
+ W + + + S + +G + ++ +R+C P LL++++
Sbjct: 883 HSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCS-APTTFLLFSQK 941
Query: 783 KDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSH 842
+ ++ ++ S D+++P+ ++++ A+D+D ++W D ++ I +A +GS
Sbjct: 942 SAINRMVIDEQQ---SPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQ 998
Query: 843 QTTIVDSNL------IWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDK 896
T+V S++ I P L+ D + IYWT TN I V++ DG ++ D+
Sbjct: 999 GFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDR 1058
Query: 897 PRDIVVNPEGGVMYWSD-WGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYW 955
PR +VVNPE G MY+++ SP IERA +DG R+ L F ++ P LALD +++W
Sbjct: 1059 PRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFW 1118
Query: 956 TDGGNKTIEYANLDGTGRTKLIE-NLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAKR 1014
D + IE ++L G R L + N+ P GL ++ + ++W D Q I+ + TG +
Sbjct: 1119 ADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDM-TGREG 1177
Query: 1015 RT 1016
RT
Sbjct: 1178 RT 1179
Score = 137 bits (332), Expect = 3e-31
Identities = 86/296 (29%), Positives = 145/296 (48%), Gaps = 13/296 (4%)
Query: 482 CSQTC-SNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSV 540
CS C + VG F CGC Y L D R+C + + LLFS + I ++ + +
Sbjct: 900 CSHLCLAVPVGGFVCGCPAHYSLNADNRTC--SAPTTFLLFSQKSAINRMVIDEQQSPDI 957
Query: 541 VKGLH---NAVALDYHYEKKLVFWSENNLRVIRVAQMN-----TKNMSDVIRWGLET-PA 591
+ +H N A+DY K ++W ++ +IR AQ + T +S V LE P
Sbjct: 958 ILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPY 1017
Query: 592 GVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWG 651
+++D ++WT T + V LDG V++ + D+PRA+ V+P +++T+
Sbjct: 1018 DLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQ 1077
Query: 652 P-NPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRR 710
+PKIERA +DG +R+ + + + P L +D K++WAD+ IE + G +R
Sbjct: 1078 ERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRI 1137
Query: 711 KVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHS 766
+ + P LT+F++ +YW D + I ++ G V A + DIH+
Sbjct: 1138 VLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHA 1193
Score = 90.2 bits (214), Expect = 6e-17
Identities = 41/120 (34%), Positives = 68/120 (56%), Gaps = 10/120 (8%)
Query: 263 CAEIDFECKNTK--CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPER 320
C+ F C + C+P ++CDG +C D +DE +CP+ C+ +F+C G+CI
Sbjct: 1249 CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV----CSESQFQCASGQCIDGA 1304
Query: 321 WRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC 380
RC+ + +C D DE NC+ C +D++ CA+ +C+ K CD DC++ DE++C
Sbjct: 1305 LRCNGDANCQDKSDEKNCEV----LCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
Score = 89.0 bits (211), Expect = 1e-16
Identities = 50/137 (36%), Positives = 65/137 (47%), Gaps = 17/137 (12%)
Query: 293 DEDSCPMVPGSCNAGEFKCNDGK--CIPERWRCDNERDCADGGDELNCKPNSIRNCSLDE 350
DE SC P +C+ +F C G+ CIP WRCD +C D DELNC CS +
Sbjct: 1239 DELSCGEPP-TCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV-----CSESQ 1292
Query: 351 YTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKH 410
+ CA +C+ C+G +C + DE NCEV C DQ+ C A C+ +
Sbjct: 1293 FQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRC---------ANGQCIGKHK 1343
Query: 411 VCDGMKDCPRGDDEERC 427
CD DC DE C
Sbjct: 1344 KCDHNVDCSDKSDELDC 1360
Score = 75.8 bits (178), Expect = 1e-12
Identities = 29/78 (37%), Positives = 50/78 (64%), Gaps = 3/78 (3%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C+E F+C + +C+ +C+GD +C D +DE +C ++ C +F+C +G+CI + +
Sbjct: 1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVL---CLIDQFRCANGQCIGKHKK 1344
Query: 323 CDNERDCADGGDELNCKP 340
CD+ DC+D DEL+C P
Sbjct: 1345 CDHNVDCSDKSDELDCYP 1362
Score = 44.4 bits (100), Expect = 0.004
Identities = 52/197 (26%), Positives = 78/197 (39%), Gaps = 22/197 (11%)
Query: 335 ELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDE--MNCEVSCEEDQYTCR 392
ELN + C+ D C+ C++K DG C+ + E+SC E TC
Sbjct: 1196 ELNLQEYRQHPCAQDNGGCS-HICLVKG---DGTTRCSCPMHLVLLQDELSCGEPP-TCS 1250
Query: 393 PQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE-KCEK-LCITTYDGH 450
PQ+ +C+ CDG +C DE CP+ CS + +C CI DG
Sbjct: 1251 PQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV---CSESQFQCASGQCI---DGA 1304
Query: 451 AACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSF-RCGCMTGYILRPDERS 509
C D+ +C + C+ +Q + C +G +C + DE
Sbjct: 1305 LRCNGDANCQDKSDEKNCEVL--CLIDQFRCANGQC---IGKHKKCDHNVDCSDKSDELD 1359
Query: 510 CKPTGESPTLLFSNRIG 526
C PT E P +N +G
Sbjct: 1360 CYPT-EEPAPQATNTVG 1375
Score = 40.3 bits (90), Expect = 0.061
Identities = 15/29 (51%), Positives = 18/29 (62%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTS 201
CI + W CDG +C D SDE+NC V S
Sbjct: 1263 CIPVAWRCDGFTECEDHSDELNCPVCSES 1291
>AF074264-1|AAC33006.1| 1613|Homo sapiens LDL receptor-related protein
6 protein.
Length = 1613
Score = 776 bits (1918), Expect = 0.0
Identities = 395/910 (43%), Positives = 552/910 (60%), Gaps = 45/910 (4%)
Query: 776 LLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINR 835
LLLYA R+DLRL + K + I V ++ A A+D+ I+W+DV ++ I R
Sbjct: 22 LLLYANRRDLRLVDATNGKE----NATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKR 77
Query: 836 AYLNGSHQT-TIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHI 894
N + +V S L+ P GLA DW+ +K+YWTD TNRIEVS DGS+R +L W +
Sbjct: 78 TEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQEL 137
Query: 895 DKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIY 954
D+PR I ++P G MYW+DWG P IERA MDG +R +I ++ WPNGL LD ++Y
Sbjct: 138 DQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLY 197
Query: 955 WTDGGNKTIEYANLDGTGRTKLIE-NLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAK 1013
W D I +NLDGT R +++ +LPHPF L L+ D ++WTDW T SI A NK TG
Sbjct: 198 WADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEG 257
Query: 1014 RR-----------------------TLGCGKNNGGCSHLCLLKPGGR--SCACPIGIKLN 1048
R T CG +NGGCSHLCL+ P CACP G+KL
Sbjct: 258 LREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLL 317
Query: 1049 KDGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNALGVDVDHSTGLIYWT 1108
++GKTC DG L+ A R D+R ISLD P D+VL L +++A+ +D D G IYWT
Sbjct: 318 ENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWT 377
Query: 1109 DTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNR 1168
D R I+R+ G+ + V+ + DGI +D R +YWTD G + IEV L+G R
Sbjct: 378 DDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMR 437
Query: 1169 KVLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAI 1228
K+L+ L+ PRAI L GYM+W+DWG KIERA +DG++R V+V+ + WPNGLA+
Sbjct: 438 KILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLAL 497
Query: 1229 DRIEGRLYWNDAKILTIESSDFDGHDRRTVLSN-VPYPYGIVIVGQHIYWTDWKTKALHR 1287
D EG++YW DAK IE + DG RR ++ + +P+ +G ++G ++YWTDW+ +++ R
Sbjct: 498 DYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIER 557
Query: 1288 ADKTNASDPIVIRKNLEGLMDIRAIQSERVL-ENACGTDNGGCSHLCLRSPLGYTCACPT 1346
K +A ++I L LM ++A RV+ N C +NGGCSHLCL P G CACP
Sbjct: 558 VHKRSAEREVII-DQLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPI 616
Query: 1347 GMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDY 1406
G FE +D K C PE FL+F+ R I ISLE+ +V +P+ VK A+D+
Sbjct: 617 G--FE-LISDM--KTC-IVPEAFLLFSRRADIRRISLETNNN-NVAIPLTGVKEASALDF 669
Query: 1407 HWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKV 1466
I++TD+ L I M N S + ++ L+ P G+ VDW+ N+YW D
Sbjct: 670 DVTDNRIYWTDISLKTISRAFM-NGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNR 728
Query: 1467 IEVARLDGSSRKVLI-TGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQ 1525
IEV++LDG R+VL+ L PRALAL PA+G++YW++WG P I+R+ +DGS+R +V
Sbjct: 729 IEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVP 788
Query: 1526 VDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQLVPDAKNPFGMTQFKDYIYW 1585
++G NGLTIDY +RRLYWTD + I++S++ G +R + D +PFG+TQ++DYIYW
Sbjct: 789 -NVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYW 847
Query: 1586 TDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAVSADRQHGWNPCKESNGGCSHLCL-F 1644
TDW ++SI RA+K +G+N T+I+ +L+ M+I + RQ GWN C SNG CSHLCL
Sbjct: 848 TDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAV 907
Query: 1645 RGHEYICACP 1654
++C CP
Sbjct: 908 PVGGFVCGCP 917
Score = 714 bits (1765), Expect = 0.0
Identities = 405/1159 (34%), Positives = 646/1159 (55%), Gaps = 61/1159 (5%)
Query: 540 VVKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWG-LETPAGVAVDWI 598
VV GL + L + + ++W+++ I V+ ++ ++ V+ W L+ P +A+D
Sbjct: 90 VVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDG-SLRKVLFWQELDQPRAIALDPS 148
Query: 599 HDLLFWTDSG-TRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIE 657
++WTD G ++E A +DGS R +++ +++ P + + + ++W D N I
Sbjct: 149 SGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLN-FIH 207
Query: 658 RADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWAD-AKHHVIERAAFDGRDRRKVTTKG 716
++++DG R+ V+ + P LT+ E +YW D + H ++ + G R++ +
Sbjct: 208 KSNLDGTNRQAVVKGSLPHPFALTL--FEDILYWTDWSTHSILACNKYTGEGLREIHSDI 265
Query: 717 LP----HPFALTLFDDAIYWTDWHTKSISTVNKNTGMG-IQTVHAGLNVPMDIHSRSCEE 771
H F+ +A S + + + V + + ++C++
Sbjct: 266 FSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKD 325
Query: 772 TPEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKD 831
+LLL ARR DLR L++ D D+V+ +E I+ A+A+D+D I+WTD E
Sbjct: 326 GATELLLLARRTDLRRISLDTP---DFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVR 382
Query: 832 TINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAW 891
I R++++GS +V + + P G+A DW+ +YWTD GT+RIEV++ +G+MR +L
Sbjct: 383 AIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILIS 442
Query: 892 DHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHN 951
+ +++PR IV++P G MYW+DWG P IERA +DG +R L+ + WPNGLALD
Sbjct: 443 EDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEG 502
Query: 952 RIYWTDGGNKTIEYANLDGTGRTKLIEN-LPHPFGLDLYGDEVFWTDWDTQSIQAANKDT 1010
+IYW D IE N DGTGR L+E+ +PH FG L GD V+WTDW +SI+ +K +
Sbjct: 503 KIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRS 562
Query: 1011 GAKR------------------RTLG---CGKNNGGCSHLCLLKPGGRSCACPIGIKLNK 1049
+ R +G C + NGGCSHLCL +P G CACPIG +L
Sbjct: 563 AEREVIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELIS 622
Query: 1050 DGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNALGVDVDHSTGLIYWTD 1109
D KTC P +L+F+ R DIR ISL+ +V +PL +K A +D D + IYWTD
Sbjct: 623 DMKTCIV-PEAFLLFSRRADIRRISLETNNN-NVAIPLTGVKEASALDFDVTDNRIYWTD 680
Query: 1110 TGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRK 1169
+ I RA G+ +E V+ GL +G+ +D G+ +YW D G N IEV++LDG++R+
Sbjct: 681 ISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQ 740
Query: 1170 VLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAID 1229
VLVW LDSPRA+AL G+M+W++WG KI+RA MDG+ R +V N + NGL ID
Sbjct: 741 VLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPN-VGRANGLTID 799
Query: 1230 RIEGRLYWNDAKILTIESSDFDGHDRRTVLSNVPYPYGIVIVGQHIYWTDWKTKALHRAD 1289
+ RLYW D IESS+ G +R + ++P+P+G+ +IYWTDW +++ RA+
Sbjct: 800 YAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERAN 859
Query: 1290 KTNASDPIVIRKNLEGLMDIRAIQSERVLE-NACGTDNGGCSHLCLRSPLG-YTCACPTG 1347
KT+ + +I+ +L+ +MDI S R N C + NG CSHLCL P+G + C CP
Sbjct: 860 KTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAH 919
Query: 1348 MPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDYH 1407
+ + ++T C S P FL+F+ + +I + ++ + D+ LP+ ++N A+DY
Sbjct: 920 --YSLNADNRT---C-SAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYD 973
Query: 1408 WDLKMIFYTDLDLNVIRSINMTNMSESKTII-----SQKLET-PNGLGVDWIANNIYWTD 1461
K +++ D N+IR S+ T++ SQ LE P L +D + IYWT
Sbjct: 974 PLDKQLYWIDSRQNMIRKAQEDG-SQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTC 1032
Query: 1462 NEHKVIEVARLDGSSRKVLITGLTE-PRALALFPAKGYLYWSDWGEH-PYIERSYLDGSQ 1519
VI V RLDG S V++ G + PRA+ + P KGY+Y+++ E P IER+ LDG++
Sbjct: 1033 EATNVINVTRLDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERSPKIERAALDGTE 1092
Query: 1520 RQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQLV-PDAKNPFGMTQ 1578
R+++ L P L +D + +L+W D+ RI++SDL+G +R+ L + P G+T
Sbjct: 1093 REVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTV 1152
Query: 1579 FKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAVSA--DRQHGWNPCKESNG 1636
F++++YW D ++ I + D + T ++ + +I AV +++ +PC + NG
Sbjct: 1153 FENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNG 1212
Query: 1637 GCSHLCLFRGHEYI-CACP 1654
GCSH+CL +G C+CP
Sbjct: 1213 GCSHICLVKGDGTTRCSCP 1231
Score = 471 bits (1160), Expect = e-131
Identities = 289/883 (32%), Positives = 452/883 (51%), Gaps = 60/883 (6%)
Query: 533 TGDNYMSVVKGLH-NAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPA 591
+G ++ + H + +A+D+ + ++W++ I V ++N +I LE P
Sbjct: 392 SGSQFVVTAQIAHPDGIAVDW--VARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPR 449
Query: 592 GVAVDWIHDLLFWTDSGT-RRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDW 650
+ +D + ++WTD G ++E A LDGS R VLV L P +A+ + ++W D
Sbjct: 450 AIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGD- 508
Query: 651 GPNPKIERADMDGDKRKTVIYDEIFWPNGLTI--DYTESKIYWADAKHHVIERAAFDGRD 708
KIE + DG R+ ++ D+I G T+ DY +YW D + IER +
Sbjct: 509 AKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDY----VYWTDWQRRSIERVHKRSAE 564
Query: 709 RRKVTTKGLPHPFALTLFD-DAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHS- 766
R + + LP L + + ++ + + Q + + ++ S
Sbjct: 565 REVIIDQ-LPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISD 623
Query: 767 -RSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFW 825
++C PE LL++RR D+R LE+ ++ ++ IP+ +K A ALD+D N I+W
Sbjct: 624 MKTCI-VPEAFLLFSRRADIRRISLET----NNNNVAIPLTGVKEASALDFDVTDNRIYW 678
Query: 826 TDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSM 885
TD+ TI+RA++NGS +V+ L +P G+A DW+ +YW D GTNRIEVSK DG
Sbjct: 679 TDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQH 738
Query: 886 RTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLA 945
R +L W +D PR + ++P G MYW++WG P I+RA MDG R L+ + NGL
Sbjct: 739 RQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLV-PNVGRANGLT 797
Query: 946 LDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIENLPHPFGLDLYGDEVFWTDWDTQSIQA 1005
+D R+YWTD IE +N+ G R + ++LPHPFGL Y D ++WTDW +SI+
Sbjct: 798 IDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIER 857
Query: 1006 ANKDTGAKR-------------------RTLG---CGKNNGGCSHLCLLKP-GGRSCACP 1042
ANK +G R R G C +NG CSHLCL P GG C CP
Sbjct: 858 ANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCP 917
Query: 1043 IGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNALGVDVDHST 1102
LN D +TC+ P +L+F+ + I + +D D++LP+ L+N +D D
Sbjct: 918 AHYSLNADNRTCS-APTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLD 976
Query: 1103 GLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTAD------GIVIDSTGRKIYWTDGGRN 1156
+YW D+ Q I++A G+ TV+ + + + + + ID R IYWT N
Sbjct: 977 KQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATN 1036
Query: 1157 SIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGT-SAKIERADMDGNNRRVI 1215
I V LDGR+ V++ D PRAI ++ E GYM++++ S KIERA +DG R V+
Sbjct: 1037 VINVTRLDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERSPKIERAALDGTEREVL 1096
Query: 1216 VDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVL-SNVPYPYGIVIVGQH 1274
+ + P LA+D G+L+W D+ + IESSD G +R + SN+ P G+ +
Sbjct: 1097 FFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENW 1156
Query: 1275 IYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQS---ERVLENACGTDNGGCSH 1331
+YW D + + + + D T ++ + L DI A++ + ++ C DNGGCSH
Sbjct: 1157 LYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSH 1216
Query: 1332 LCLRSPLGYT-CACPTGMP-FEKSTTDQTPKKCKSHPEEFLIF 1372
+CL G T C+CP + + + P C P++F F
Sbjct: 1217 ICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCS--PQQFTCF 1257
Score = 323 bits (794), Expect = 3e-87
Identities = 194/513 (37%), Positives = 275/513 (53%), Gaps = 16/513 (3%)
Query: 516 SPTLLFSNRIGIRQVWLTG--DNYMSVVKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQ 573
+P LL++NR +R V T +N VV GL +A A+D+ + L++WS+ + I+ +
Sbjct: 20 APLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTE 79
Query: 574 MN-TKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDK 632
N T+++ +V+ GL +P G+A DW+ + L+WTDS T R+EV+ LDGS R VL +LD+
Sbjct: 80 FNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQ 139
Query: 633 PRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWA 692
PRAIA+ P ++WTDWG PKIERA MDG R +I EI+WPNGLT+DY E K+YWA
Sbjct: 140 PRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWA 199
Query: 693 DAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQ 752
DAK + I ++ DG +R+ V LPHPFALTLF+D +YWTDW T SI NK TG G++
Sbjct: 200 DAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLR 259
Query: 753 TVHAGLNVPMDIHSRSCEETPEKLLLYARRKD--LRLKQLESKKPIDSLDMVIPVETIKS 810
+H+ + PMDIH+ S + P L + KP V+ +++
Sbjct: 260 EIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLEN 319
Query: 811 AVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIV--DSNLIWPAGLAFDWITDKIYW 868
D + + + + R L+ T IV ++ + +D + IYW
Sbjct: 320 GKTCK-DGATELLLL--ARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYW 376
Query: 869 TDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGG 928
TD I S DGS + I P I V+ +YW+D G IE ++G
Sbjct: 377 TDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDR-IEVTRLNGT 435
Query: 929 NRKKLIFGQMTWPNGLALDLVHNRIYWTDGGN-KTIEYANLDGTGRTKLIE-NLPHPFGL 986
RK LI + P + LD + +YWTD G IE A LDG+ R L+ +L P GL
Sbjct: 436 MRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGL 495
Query: 987 DLYGDE--VFWTDWDTQSIQAANKDTGAKRRTL 1017
L DE ++W D T I+ N D G RR L
Sbjct: 496 ALDYDEGKIYWGDAKTDKIEVMNTD-GTGRRVL 527
Score = 281 bits (688), Expect = 2e-74
Identities = 179/546 (32%), Positives = 278/546 (50%), Gaps = 39/546 (7%)
Query: 482 CSQTC--SNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMS 539
CS C S ++C C TG L + ++CK G + LL + R +R++ L ++
Sbjct: 293 CSHLCLMSPVKPFYQCACPTGVKLLENGKTCKD-GATELLLLARRTDLRRISLDTPDFTD 351
Query: 540 VV---KGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVD 596
+V + + +A+A+DY + ++W+++ +R IR + ++ V+ + P G+AVD
Sbjct: 352 IVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVD 411
Query: 597 WIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKI 656
W+ L+WTD+GT R+EV L+G+ R +L++ DL++PRAI + P ++WTDWG PKI
Sbjct: 412 WVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKI 471
Query: 657 ERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKG 716
ERA +DG R ++ + WPNGL +DY E KIYW DAK IE DG RR +
Sbjct: 472 ERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDK 531
Query: 717 LPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVH-----AGL---NVPMDIHSRS 768
+PH F TL D +YWTDW +SI V+K + + GL NV I S
Sbjct: 532 IPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRVIGSNP 591
Query: 769 CEETP---EKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFW 825
C E L LY R + L PI +++ ++T A + I
Sbjct: 592 CAEENGGCSHLCLY------RPQGLRCACPI-GFELISDMKTCIVPEAFLLFSRRADIRR 644
Query: 826 TDVEKDTINRAY-LNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGS 884
+E + N A L G + + +D FD ++IYWTD I + +GS
Sbjct: 645 ISLETNNNNVAIPLTGVKEASALD----------FDVTDNRIYWTDISLKTISRAFMNGS 694
Query: 885 MRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGL 944
+ +D P + V+ G +YW+D G + IE + +DG +R+ L++ + P L
Sbjct: 695 ALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNR-IEVSKLDGQHRQVLVWKDLDSPRAL 753
Query: 945 ALDLVHNRIYWTD-GGNKTIEYANLDGTGRTKLIENLPHPFGL--DLYGDEVFWTDWDTQ 1001
ALD +YWT+ GG I+ A +DG+ RT L+ N+ GL D ++WTD DT
Sbjct: 754 ALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTN 813
Query: 1002 SIQAAN 1007
I+++N
Sbjct: 814 LIESSN 819
Score = 262 bits (641), Expect = 1e-68
Identities = 175/563 (31%), Positives = 283/563 (50%), Gaps = 39/563 (6%)
Query: 477 EQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWL-TGD 535
E++ CS C RC C G+ L D ++C LLFS R IR++ L T +
Sbjct: 594 EENGGCSHLCLYRPQGLRCACPIGFELISDMKTC--IVPEAFLLFSRRADIRRISLETNN 651
Query: 536 NYMSV-VKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVA 594
N +++ + G+ A ALD+ ++W++ +L+ I A MN + V+ +GL+ P G+A
Sbjct: 652 NNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMA 711
Query: 595 VDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNP 654
VDW+ L+W D+GT R+EV+ LDG R VLV DLD PRA+A+ P + ++WT+WG P
Sbjct: 712 VDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKP 771
Query: 655 KIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTT 714
KI+RA MDG +R T++ + NGLTIDY + ++YW D ++IE + G + R+V
Sbjct: 772 KIDRAAMDGSERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLN-REVIA 829
Query: 715 KGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPE 774
LPHPF LT + D IYWTDW +SI NK +G + L+ MDI
Sbjct: 830 DDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDI---------- 879
Query: 775 KLLLYARRKDLRLKQLESKKPIDSLDMVIPVETI----KSAVALDWDQKSNS---IFWTD 827
L+ ++ R+ + S L + +PV + +L+ D ++ S F
Sbjct: 880 -LVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLF 938
Query: 828 VEKDTINRAYLNGSHQTTIV--DSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSM 885
+K INR ++ I+ +L + +D + ++YW D N I ++ DGS
Sbjct: 939 SQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQ 998
Query: 886 RTLLAWDHID------KPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMT 939
+ + +P D+ ++ +YW+ A+ I +DG + ++ G+
Sbjct: 999 GFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWT-CEATNVINVTRLDGRSVGVVLKGEQD 1057
Query: 940 WPNGLALDLVHNRIYWTDGGNKT--IEYANLDGTGRTKL-IENLPHPFGLDLYG--DEVF 994
P + ++ +Y+T+ ++ IE A LDGT R L L P L L ++F
Sbjct: 1058 RPRAIVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLF 1117
Query: 995 WTDWDTQSIQAANKDTGAKRRTL 1017
W D D + I++++ +GA R L
Sbjct: 1118 WADSDLRRIESSDL-SGANRIVL 1139
Score = 197 bits (481), Expect = 3e-49
Identities = 159/602 (26%), Positives = 290/602 (48%), Gaps = 35/602 (5%)
Query: 435 AEEK--CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDE-CMYEQDPVCSQTCSNTVG 491
AEE C LC+ G CACP+GF L D +C + ++ + + T
Sbjct: 593 AEENGGCSHLCLYRPQG-LRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNN 651
Query: 492 SFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQV---WLTGDNYMSVVK-GLHNA 547
+ +TG E S + ++ I ++ + ++ G VV+ GL
Sbjct: 652 NNVAIPLTGV----KEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYP 707
Query: 548 VALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDS 607
+ + K ++W++ I V++++ ++ ++ L++P +A+D ++WT+
Sbjct: 708 EGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEW 767
Query: 608 GTR-RVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKR 666
G + +++ A +DGS+R LV N + + + + ++WTD N IE ++M G R
Sbjct: 768 GGKPKIDRAAMDGSERTTLVPN-VGRANGLTIDYAKRRLYWTDLDTN-LIESSNMLGLNR 825
Query: 667 KTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLF 726
+ VI D++ P GLT Y + IYW D IERA R + L + + +F
Sbjct: 826 E-VIADDLPHPFGLT-QY-QDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVF 882
Query: 727 DDAIY--WTDWHTKS--ISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARR 782
+ W + + + S + +G + ++ +R+C P LL++++
Sbjct: 883 HSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCS-APTTFLLFSQK 941
Query: 783 KDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSH 842
+ ++ ++ S D+++P+ ++++ A+D+D ++W D ++ I +A +GS
Sbjct: 942 SAINRMVIDEQQ---SPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQ 998
Query: 843 QTTIVDSNL------IWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDK 896
T+V S++ I P L+ D + IYWT TN I V++ DG ++ D+
Sbjct: 999 GFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDR 1058
Query: 897 PRDIVVNPEGGVMYWSD-WGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYW 955
PR IVVNPE G MY+++ SP IERA +DG R+ L F ++ P LALD +++W
Sbjct: 1059 PRAIVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFW 1118
Query: 956 TDGGNKTIEYANLDGTGRTKLIE-NLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAKR 1014
D + IE ++L G R L + N+ P GL ++ + ++W D Q I+ + TG +
Sbjct: 1119 ADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDM-TGREG 1177
Query: 1015 RT 1016
RT
Sbjct: 1178 RT 1179
Score = 138 bits (333), Expect = 2e-31
Identities = 87/296 (29%), Positives = 145/296 (48%), Gaps = 13/296 (4%)
Query: 482 CSQTC-SNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSV 540
CS C + VG F CGC Y L D R+C + + LLFS + I ++ + +
Sbjct: 900 CSHLCLAVPVGGFVCGCPAHYSLNADNRTC--SAPTTFLLFSQKSAINRMVIDEQQSPDI 957
Query: 541 VKGLH---NAVALDYHYEKKLVFWSENNLRVIRVAQMN-----TKNMSDVIRWGLET-PA 591
+ +H N A+DY K ++W ++ +IR AQ + T +S V LE P
Sbjct: 958 ILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPY 1017
Query: 592 GVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWG 651
+++D ++WT T + V LDG V++ + D+PRAI V+P +++T+
Sbjct: 1018 DLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQ 1077
Query: 652 P-NPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRR 710
+PKIERA +DG +R+ + + + P L +D K++WAD+ IE + G +R
Sbjct: 1078 ERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRI 1137
Query: 711 KVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHS 766
+ + P LT+F++ +YW D + I ++ G V A + DIH+
Sbjct: 1138 VLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHA 1193
Score = 90.2 bits (214), Expect = 6e-17
Identities = 41/120 (34%), Positives = 68/120 (56%), Gaps = 10/120 (8%)
Query: 263 CAEIDFECKNTK--CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPER 320
C+ F C + C+P ++CDG +C D +DE +CP+ C+ +F+C G+CI
Sbjct: 1249 CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV----CSESQFQCASGQCIDGA 1304
Query: 321 WRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC 380
RC+ + +C D DE NC+ C +D++ CA+ +C+ K CD DC++ DE++C
Sbjct: 1305 LRCNGDANCQDKSDEKNCEV----LCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
Score = 89.0 bits (211), Expect = 1e-16
Identities = 50/137 (36%), Positives = 65/137 (47%), Gaps = 17/137 (12%)
Query: 293 DEDSCPMVPGSCNAGEFKCNDGK--CIPERWRCDNERDCADGGDELNCKPNSIRNCSLDE 350
DE SC P +C+ +F C G+ CIP WRCD +C D DELNC CS +
Sbjct: 1239 DELSCGEPP-TCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV-----CSESQ 1292
Query: 351 YTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKH 410
+ CA +C+ C+G +C + DE NCEV C DQ+ C A C+ +
Sbjct: 1293 FQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRC---------ANGQCIGKHK 1343
Query: 411 VCDGMKDCPRGDDEERC 427
CD DC DE C
Sbjct: 1344 KCDHNVDCSDKSDELDC 1360
Score = 75.8 bits (178), Expect = 1e-12
Identities = 29/78 (37%), Positives = 50/78 (64%), Gaps = 3/78 (3%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C+E F+C + +C+ +C+GD +C D +DE +C ++ C +F+C +G+CI + +
Sbjct: 1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVL---CLIDQFRCANGQCIGKHKK 1344
Query: 323 CDNERDCADGGDELNCKP 340
CD+ DC+D DEL+C P
Sbjct: 1345 CDHNVDCSDKSDELDCYP 1362
Score = 44.4 bits (100), Expect = 0.004
Identities = 52/197 (26%), Positives = 78/197 (39%), Gaps = 22/197 (11%)
Query: 335 ELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDE--MNCEVSCEEDQYTCR 392
ELN + C+ D C+ C++K DG C+ + E+SC E TC
Sbjct: 1196 ELNLQEYRQHPCAQDNGGCS-HICLVKG---DGTTRCSCPMHLVLLQDELSCGEPP-TCS 1250
Query: 393 PQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE-KCEK-LCITTYDGH 450
PQ+ +C+ CDG +C DE CP+ CS + +C CI DG
Sbjct: 1251 PQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV---CSESQFQCASGQCI---DGA 1304
Query: 451 AACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSF-RCGCMTGYILRPDERS 509
C D+ +C + C+ +Q + C +G +C + DE
Sbjct: 1305 LRCNGDANCQDKSDEKNCEVL--CLIDQFRCANGQC---IGKHKKCDHNVDCSDKSDELD 1359
Query: 510 CKPTGESPTLLFSNRIG 526
C PT E P +N +G
Sbjct: 1360 CYPT-EEPAPQATNTVG 1375
Score = 40.3 bits (90), Expect = 0.061
Identities = 15/29 (51%), Positives = 18/29 (62%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTS 201
CI + W CDG +C D SDE+NC V S
Sbjct: 1263 CIPVAWRCDGFTECEDHSDELNCPVCSES 1291
>AB209683-1|BAD92920.1| 1477|Homo sapiens low density lipoprotein
receptor-related protein 6 variant protein.
Length = 1477
Score = 705 bits (1742), Expect = 0.0
Identities = 395/1111 (35%), Positives = 622/1111 (55%), Gaps = 59/1111 (5%)
Query: 587 LETPAGVAVDWIHDLLFWTDSG-TRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALV 645
L+ P +A+D ++WTD G ++E A +DGS R +++ +++ P + + + +
Sbjct: 1 LDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKL 60
Query: 646 FWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWAD-AKHHVIERAAF 704
+W D N I ++++DG R+ V+ + P LT+ E +YW D + H ++ +
Sbjct: 61 YWADAKLN-FIHKSNLDGTNRQAVVKGSLPHPFALTL--FEDILYWTDWSTHSILACNKY 117
Query: 705 DGRDRRKVTTKGLP----HPFALTLFDDAIYWTDWHTKSISTVNKNTGMG-IQTVHAGLN 759
G R++ + H F+ +A S + + +
Sbjct: 118 TGEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTG 177
Query: 760 VPMDIHSRSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQK 819
V + + ++C++ +LLL ARR DLR L++ D D+V+ +E I+ A+A+D+D
Sbjct: 178 VKLLENGKTCKDGATELLLLARRTDLRRISLDTP---DFTDIVLQLEDIRHAIAIDYDPV 234
Query: 820 SNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVS 879
I+WTD E I R++++GS +V + + P G+A DW+ +YWTD GT+RIEV+
Sbjct: 235 EGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVT 294
Query: 880 KSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMT 939
+ +G+MR +L + +++PR IV++P G MYW+DWG P IERA +DG +R L+ +
Sbjct: 295 RLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLG 354
Query: 940 WPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN-LPHPFGLDLYGDEVFWTDW 998
WPNGLALD +IYW D IE N DGTGR L+E+ +PH FG L GD V+WTDW
Sbjct: 355 WPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDW 414
Query: 999 DTQSIQAANKDTGAKR------------------RTLG---CGKNNGGCSHLCLLKPGGR 1037
+SI+ +K + + R +G C + NGGCSHLCL +P G
Sbjct: 415 QRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGL 474
Query: 1038 SCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNALGVD 1097
CACPIG +L D KTC P +L+F+ R DIR ISL+ +V +PL +K A +D
Sbjct: 475 RCACPIGFELISDMKTCIV-PEAFLLFSRRADIRRISLETNNN-NVAIPLTGVKEASALD 532
Query: 1098 VDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNS 1157
D + IYWTD + I RA G+ +E V+ GL +G+ +D G+ +YW D G N
Sbjct: 533 FDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNR 592
Query: 1158 IEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVD 1217
IEV++LDG++R+VLVW LDSPRA+AL G+M+W++WG KI+RA MDG+ R +V
Sbjct: 593 IEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVP 652
Query: 1218 NKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLSNVPYPYGIVIVGQHIYW 1277
N + NGL ID + RLYW D IESS+ G +R + ++P+P+G+ +IYW
Sbjct: 653 N-VGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYW 711
Query: 1278 TDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQSERVLE-NACGTDNGGCSHLCLRS 1336
TDW +++ RA+KT+ + +I+ +L+ +MDI S R N C + NG CSHLCL
Sbjct: 712 TDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAV 771
Query: 1337 PLG-YTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPV 1395
P+G + C CP + + ++T C S P FL+F+ + +I + ++ + D+ LP+
Sbjct: 772 PVGGFVCGCPAH--YSLNADNRT---C-SAPTTFLLFSQKSAINRMVIDEQQSPDIILPI 825
Query: 1396 KEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTII-----SQKLET-PNGLG 1449
++N A+DY K +++ D N+IR S+ T++ SQ LE P L
Sbjct: 826 HSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDG-SQGFTVVVSSVPSQNLEIQPYDLS 884
Query: 1450 VDWIANNIYWTDNEHKVIEVARLDGSSRKVLITGLTE-PRALALFPAKGYLYWSDWGEH- 1507
+D + IYWT VI V RLDG S V++ G + PRA+ + P KGY+Y+++ E
Sbjct: 885 IDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERS 944
Query: 1508 PYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQLV 1567
P IER+ LDG++R+++ L P L +D + +L+W D+ RI++SDL+G +R+ L
Sbjct: 945 PKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLE 1004
Query: 1568 -PDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAVSA--DR 1624
+ P G+T F++++YW D ++ I + D + T ++ + +I AV +
Sbjct: 1005 DSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQ 1064
Query: 1625 QHGWNPCKESNGGCSHLCLFRGHEYI-CACP 1654
++ +PC + NGGCSH+CL +G C+CP
Sbjct: 1065 EYRQHPCAQDNGGCSHICLVKGDGTTRCSCP 1095
Score = 471 bits (1160), Expect = e-131
Identities = 289/883 (32%), Positives = 452/883 (51%), Gaps = 60/883 (6%)
Query: 533 TGDNYMSVVKGLH-NAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPA 591
+G ++ + H + +A+D+ + ++W++ I V ++N +I LE P
Sbjct: 256 SGSQFVVTAQIAHPDGIAVDW--VARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPR 313
Query: 592 GVAVDWIHDLLFWTDSGT-RRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDW 650
+ +D + ++WTD G ++E A LDGS R VLV L P +A+ + ++W D
Sbjct: 314 AIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGD- 372
Query: 651 GPNPKIERADMDGDKRKTVIYDEIFWPNGLTI--DYTESKIYWADAKHHVIERAAFDGRD 708
KIE + DG R+ ++ D+I G T+ DY +YW D + IER +
Sbjct: 373 AKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDY----VYWTDWQRRSIERVHKRSAE 428
Query: 709 RRKVTTKGLPHPFALTLFD-DAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHS- 766
R + + LP L + + ++ + + Q + + ++ S
Sbjct: 429 REVIIDQ-LPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISD 487
Query: 767 -RSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFW 825
++C PE LL++RR D+R LE+ ++ ++ IP+ +K A ALD+D N I+W
Sbjct: 488 MKTCI-VPEAFLLFSRRADIRRISLET----NNNNVAIPLTGVKEASALDFDVTDNRIYW 542
Query: 826 TDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSM 885
TD+ TI+RA++NGS +V+ L +P G+A DW+ +YW D GTNRIEVSK DG
Sbjct: 543 TDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQH 602
Query: 886 RTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLA 945
R +L W +D PR + ++P G MYW++WG P I+RA MDG R L+ + NGL
Sbjct: 603 RQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLV-PNVGRANGLT 661
Query: 946 LDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIENLPHPFGLDLYGDEVFWTDWDTQSIQA 1005
+D R+YWTD IE +N+ G R + ++LPHPFGL Y D ++WTDW +SI+
Sbjct: 662 IDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIER 721
Query: 1006 ANKDTGAKR-------------------RTLG---CGKNNGGCSHLCLLKP-GGRSCACP 1042
ANK +G R R G C +NG CSHLCL P GG C CP
Sbjct: 722 ANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCP 781
Query: 1043 IGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNALGVDVDHST 1102
LN D +TC+ P +L+F+ + I + +D D++LP+ L+N +D D
Sbjct: 782 AHYSLNADNRTCS-APTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLD 840
Query: 1103 GLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTAD------GIVIDSTGRKIYWTDGGRN 1156
+YW D+ Q I++A G+ TV+ + + + + + ID R IYWT N
Sbjct: 841 KQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATN 900
Query: 1157 SIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGT-SAKIERADMDGNNRRVI 1215
I V LDGR+ V++ D PRAI ++ E GYM++++ S KIERA +DG R V+
Sbjct: 901 VINVTRLDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERSPKIERAALDGTEREVL 960
Query: 1216 VDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVL-SNVPYPYGIVIVGQH 1274
+ + P LA+D G+L+W D+ + IESSD G +R + SN+ P G+ +
Sbjct: 961 FFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENW 1020
Query: 1275 IYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQS---ERVLENACGTDNGGCSH 1331
+YW D + + + + D T ++ + L DI A++ + ++ C DNGGCSH
Sbjct: 1021 LYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSH 1080
Query: 1332 LCLRSPLGYT-CACPTGMP-FEKSTTDQTPKKCKSHPEEFLIF 1372
+CL G T C+CP + + + P C P++F F
Sbjct: 1081 ICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCS--PQQFTCF 1121
Score = 281 bits (688), Expect = 2e-74
Identities = 179/546 (32%), Positives = 278/546 (50%), Gaps = 39/546 (7%)
Query: 482 CSQTC--SNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMS 539
CS C S ++C C TG L + ++CK G + LL + R +R++ L ++
Sbjct: 157 CSHLCLMSPVKPFYQCACPTGVKLLENGKTCKD-GATELLLLARRTDLRRISLDTPDFTD 215
Query: 540 VV---KGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVD 596
+V + + +A+A+DY + ++W+++ +R IR + ++ V+ + P G+AVD
Sbjct: 216 IVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVD 275
Query: 597 WIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKI 656
W+ L+WTD+GT R+EV L+G+ R +L++ DL++PRAI + P ++WTDWG PKI
Sbjct: 276 WVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKI 335
Query: 657 ERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKG 716
ERA +DG R ++ + WPNGL +DY E KIYW DAK IE DG RR +
Sbjct: 336 ERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDK 395
Query: 717 LPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVH-----AGL---NVPMDIHSRS 768
+PH F TL D +YWTDW +SI V+K + + GL NV I S
Sbjct: 396 IPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRVIGSNP 455
Query: 769 CEETP---EKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFW 825
C E L LY R + L PI +++ ++T A + I
Sbjct: 456 CAEENGGCSHLCLY------RPQGLRCACPI-GFELISDMKTCIVPEAFLLFSRRADIRR 508
Query: 826 TDVEKDTINRAY-LNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGS 884
+E + N A L G + + +D FD ++IYWTD I + +GS
Sbjct: 509 ISLETNNNNVAIPLTGVKEASALD----------FDVTDNRIYWTDISLKTISRAFMNGS 558
Query: 885 MRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGL 944
+ +D P + V+ G +YW+D G + IE + +DG +R+ L++ + P L
Sbjct: 559 ALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNR-IEVSKLDGQHRQVLVWKDLDSPRAL 617
Query: 945 ALDLVHNRIYWTD-GGNKTIEYANLDGTGRTKLIENLPHPFGL--DLYGDEVFWTDWDTQ 1001
ALD +YWT+ GG I+ A +DG+ RT L+ N+ GL D ++WTD DT
Sbjct: 618 ALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTN 677
Query: 1002 SIQAAN 1007
I+++N
Sbjct: 678 LIESSN 683
Score = 262 bits (641), Expect = 1e-68
Identities = 175/563 (31%), Positives = 283/563 (50%), Gaps = 39/563 (6%)
Query: 477 EQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWL-TGD 535
E++ CS C RC C G+ L D ++C LLFS R IR++ L T +
Sbjct: 458 EENGGCSHLCLYRPQGLRCACPIGFELISDMKTC--IVPEAFLLFSRRADIRRISLETNN 515
Query: 536 NYMSV-VKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVA 594
N +++ + G+ A ALD+ ++W++ +L+ I A MN + V+ +GL+ P G+A
Sbjct: 516 NNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMA 575
Query: 595 VDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNP 654
VDW+ L+W D+GT R+EV+ LDG R VLV DLD PRA+A+ P + ++WT+WG P
Sbjct: 576 VDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKP 635
Query: 655 KIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTT 714
KI+RA MDG +R T++ + NGLTIDY + ++YW D ++IE + G + R+V
Sbjct: 636 KIDRAAMDGSERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLN-REVIA 693
Query: 715 KGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPE 774
LPHPF LT + D IYWTDW +SI NK +G + L+ MDI
Sbjct: 694 DDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDI---------- 743
Query: 775 KLLLYARRKDLRLKQLESKKPIDSLDMVIPVETI----KSAVALDWDQKSNS---IFWTD 827
L+ ++ R+ + S L + +PV + +L+ D ++ S F
Sbjct: 744 -LVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLF 802
Query: 828 VEKDTINRAYLNGSHQTTIV--DSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSM 885
+K INR ++ I+ +L + +D + ++YW D N I ++ DGS
Sbjct: 803 SQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQ 862
Query: 886 RTLLAWDHID------KPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMT 939
+ + +P D+ ++ +YW+ A+ I +DG + ++ G+
Sbjct: 863 GFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWT-CEATNVINVTRLDGRSVGVVLKGEQD 921
Query: 940 WPNGLALDLVHNRIYWTDGGNKT--IEYANLDGTGRTKL-IENLPHPFGLDLYG--DEVF 994
P + ++ +Y+T+ ++ IE A LDGT R L L P L L ++F
Sbjct: 922 RPRAIVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLF 981
Query: 995 WTDWDTQSIQAANKDTGAKRRTL 1017
W D D + I++++ +GA R L
Sbjct: 982 WADSDLRRIESSDL-SGANRIVL 1003
Score = 197 bits (481), Expect = 3e-49
Identities = 159/602 (26%), Positives = 290/602 (48%), Gaps = 35/602 (5%)
Query: 435 AEEK--CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDE-CMYEQDPVCSQTCSNTVG 491
AEE C LC+ G CACP+GF L D +C + ++ + + T
Sbjct: 457 AEENGGCSHLCLYRPQG-LRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNN 515
Query: 492 SFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQV---WLTGDNYMSVVK-GLHNA 547
+ +TG E S + ++ I ++ + ++ G VV+ GL
Sbjct: 516 NNVAIPLTGV----KEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYP 571
Query: 548 VALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDS 607
+ + K ++W++ I V++++ ++ ++ L++P +A+D ++WT+
Sbjct: 572 EGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEW 631
Query: 608 GTR-RVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKR 666
G + +++ A +DGS+R LV N + + + + ++WTD N IE ++M G R
Sbjct: 632 GGKPKIDRAAMDGSERTTLVPN-VGRANGLTIDYAKRRLYWTDLDTN-LIESSNMLGLNR 689
Query: 667 KTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLF 726
+ VI D++ P GLT Y + IYW D IERA R + L + + +F
Sbjct: 690 E-VIADDLPHPFGLT-QY-QDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVF 746
Query: 727 DDAIY--WTDWHTKS--ISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARR 782
+ W + + + S + +G + ++ +R+C P LL++++
Sbjct: 747 HSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCS-APTTFLLFSQK 805
Query: 783 KDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSH 842
+ ++ ++ S D+++P+ ++++ A+D+D ++W D ++ I +A +GS
Sbjct: 806 SAINRMVIDEQQ---SPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQ 862
Query: 843 QTTIVDSNL------IWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDK 896
T+V S++ I P L+ D + IYWT TN I V++ DG ++ D+
Sbjct: 863 GFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDR 922
Query: 897 PRDIVVNPEGGVMYWSD-WGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYW 955
PR IVVNPE G MY+++ SP IERA +DG R+ L F ++ P LALD +++W
Sbjct: 923 PRAIVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFW 982
Query: 956 TDGGNKTIEYANLDGTGRTKLIE-NLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAKR 1014
D + IE ++L G R L + N+ P GL ++ + ++W D Q I+ + TG +
Sbjct: 983 ADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDM-TGREG 1041
Query: 1015 RT 1016
RT
Sbjct: 1042 RT 1043
Score = 138 bits (333), Expect = 2e-31
Identities = 87/296 (29%), Positives = 145/296 (48%), Gaps = 13/296 (4%)
Query: 482 CSQTC-SNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSV 540
CS C + VG F CGC Y L D R+C + + LLFS + I ++ + +
Sbjct: 764 CSHLCLAVPVGGFVCGCPAHYSLNADNRTC--SAPTTFLLFSQKSAINRMVIDEQQSPDI 821
Query: 541 VKGLH---NAVALDYHYEKKLVFWSENNLRVIRVAQMN-----TKNMSDVIRWGLET-PA 591
+ +H N A+DY K ++W ++ +IR AQ + T +S V LE P
Sbjct: 822 ILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPY 881
Query: 592 GVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWG 651
+++D ++WT T + V LDG V++ + D+PRAI V+P +++T+
Sbjct: 882 DLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQ 941
Query: 652 P-NPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRR 710
+PKIERA +DG +R+ + + + P L +D K++WAD+ IE + G +R
Sbjct: 942 ERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRI 1001
Query: 711 KVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHS 766
+ + P LT+F++ +YW D + I ++ G V A + DIH+
Sbjct: 1002 VLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHA 1057
Score = 90.2 bits (214), Expect = 6e-17
Identities = 41/120 (34%), Positives = 68/120 (56%), Gaps = 10/120 (8%)
Query: 263 CAEIDFECKNTK--CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPER 320
C+ F C + C+P ++CDG +C D +DE +CP+ C+ +F+C G+CI
Sbjct: 1113 CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV----CSESQFQCASGQCIDGA 1168
Query: 321 WRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC 380
RC+ + +C D DE NC+ C +D++ CA+ +C+ K CD DC++ DE++C
Sbjct: 1169 LRCNGDANCQDKSDEKNCEV----LCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1224
Score = 89.0 bits (211), Expect = 1e-16
Identities = 50/137 (36%), Positives = 65/137 (47%), Gaps = 17/137 (12%)
Query: 293 DEDSCPMVPGSCNAGEFKCNDGK--CIPERWRCDNERDCADGGDELNCKPNSIRNCSLDE 350
DE SC P +C+ +F C G+ CIP WRCD +C D DELNC CS +
Sbjct: 1103 DELSCGEPP-TCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV-----CSESQ 1156
Query: 351 YTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKH 410
+ CA +C+ C+G +C + DE NCEV C DQ+ C A C+ +
Sbjct: 1157 FQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRC---------ANGQCIGKHK 1207
Query: 411 VCDGMKDCPRGDDEERC 427
CD DC DE C
Sbjct: 1208 KCDHNVDCSDKSDELDC 1224
Score = 75.8 bits (178), Expect = 1e-12
Identities = 29/78 (37%), Positives = 50/78 (64%), Gaps = 3/78 (3%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C+E F+C + +C+ +C+GD +C D +DE +C ++ C +F+C +G+CI + +
Sbjct: 1152 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVL---CLIDQFRCANGQCIGKHKK 1208
Query: 323 CDNERDCADGGDELNCKP 340
CD+ DC+D DEL+C P
Sbjct: 1209 CDHNVDCSDKSDELDCYP 1226
Score = 50.0 bits (114), Expect = 8e-05
Identities = 32/132 (24%), Positives = 63/132 (47%), Gaps = 6/132 (4%)
Query: 547 AVALDYHYEKKLVFWSE-NNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWT 605
A+ALD ++W++ + I A M+ + +I + P G+ +D+ L+W
Sbjct: 6 AIALDP--SSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWA 63
Query: 606 DSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDK 665
D+ + + LDG+ R +V L P A+ + + +++WTDW + + G+
Sbjct: 64 DAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLF--EDILYWTDWSTHSILACNKYTGEG 121
Query: 666 RKTVIYDEIFWP 677
+ I+ +IF P
Sbjct: 122 LRE-IHSDIFSP 132
Score = 44.4 bits (100), Expect = 0.004
Identities = 52/197 (26%), Positives = 78/197 (39%), Gaps = 22/197 (11%)
Query: 335 ELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDE--MNCEVSCEEDQYTCR 392
ELN + C+ D C+ C++K DG C+ + E+SC E TC
Sbjct: 1060 ELNLQEYRQHPCAQDNGGCS-HICLVKG---DGTTRCSCPMHLVLLQDELSCGEPP-TCS 1114
Query: 393 PQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE-KCEK-LCITTYDGH 450
PQ+ +C+ CDG +C DE CP+ CS + +C CI DG
Sbjct: 1115 PQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV---CSESQFQCASGQCI---DGA 1168
Query: 451 AACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSF-RCGCMTGYILRPDERS 509
C D+ +C + C+ +Q + C +G +C + DE
Sbjct: 1169 LRCNGDANCQDKSDEKNCEVL--CLIDQFRCANGQC---IGKHKKCDHNVDCSDKSDELD 1223
Query: 510 CKPTGESPTLLFSNRIG 526
C PT E P +N +G
Sbjct: 1224 CYPT-EEPAPQATNTVG 1239
Score = 40.3 bits (90), Expect = 0.061
Identities = 15/29 (51%), Positives = 18/29 (62%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTS 201
CI + W CDG +C D SDE+NC V S
Sbjct: 1127 CIPVAWRCDGFTECEDHSDELNCPVCSES 1155
>U33837-1|AAB41649.1| 4655|Homo sapiens gp330 precursor protein.
Length = 4655
Score = 603 bits (1490), Expect = e-171
Identities = 473/1634 (28%), Positives = 743/1634 (45%), Gaps = 156/1634 (9%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
CI L ++CDGD DC D SDE+ C + T+ A+ IG +TN +
Sbjct: 1161 CIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIG--VTNRCDGV-------- 1210
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTK-CVPKDFQCDGDNDCGDW 291
F D A P +P + C +F+C+ C+P ++CDG DC
Sbjct: 1211 -----FDCSDNSDEAGCP----TRPPGM--CHSDEFQCQEDGICIPNFWECDGHPDCLYG 1259
Query: 292 TDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEY 351
+DE + VP +C + F C++G CI W CD + DC D DE +C R C ++
Sbjct: 1260 SDEHNA-CVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFR-CPSWQW 1317
Query: 352 TCADRR-CVLKTWLCDGVRDCTNGEDEMN-CEV-SCEEDQYTCRPQEHLMSNAFRNCVNR 408
C CV + +CDG+ DC NG DE C SC + C + CV
Sbjct: 1318 QCLGHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHE----------CVQE 1367
Query: 409 KHVCDGMKDCPRG----DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAED 464
+ CP G +D + C +C C + C G C+C G++L D
Sbjct: 1368 PFGAKCL--CPLGFLLANDSKTCEDIDECDILGSCSQHCYNMR-GSFRCSCDTGYMLESD 1424
Query: 465 KYSCR-DIDECMY----EQDPVCSQTCSNTVGSFRCGCMTG-YILRPDERSCK------- 511
+C+ E + Q+ + + + ++ V + G YI+ D S
Sbjct: 1425 GRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSD 1484
Query: 512 PTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLVFWSENNLRVIRV 571
T F N R V+ D+ S++ L +A+D+ + ++W++ L I V
Sbjct: 1485 ATQGKTWSAFQNGTDRRVVF---DS--SII--LTETIAIDW--VGRNLYWTDYALETIEV 1535
Query: 572 AQMNTKNMSDVIRWGLETPAGVAVD--WIHDLLFWTDSGTR-RVEVATLDGSKRAVLVAN 628
++++ + + +I L P G+A+D LLFW+D G R+E A++DGS R V+V +
Sbjct: 1536 SKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQD 1595
Query: 629 DLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESK 688
+ P + + + L+++ D ++ D +G R+ VI ++ + + E
Sbjct: 1596 KIFWPCGLTIDYPNRLLYFMD-SYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDS 1654
Query: 689 IYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTG 748
+YW D + RA + V + P + + + + S +
Sbjct: 1655 VYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFSRCSHLCL 1714
Query: 749 MGIQTVH-------AGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDM 801
+ Q H +G ++ D+ +C + L+ R+ + L + + S D
Sbjct: 1715 LSSQGPHFYSCVCPSGWSLSPDL--LNCLRDDQPFLITVRQHIIFGISLNPE--VKSNDA 1770
Query: 802 VIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPA-GLAFD 860
++P+ I++ + +++D I+W + I+R +G+++T +++ P+ LA D
Sbjct: 1771 MVPIAGIQNGLDVEFDDAEQYIYWVE-NPGEIHRVKTDGTNRTVFASISMVGPSMNLALD 1829
Query: 861 WITDKIYWTDGGTNRIEVSKSDGSMR---TLLAWDH----IDKPRDIVVNPEGGVMYWSD 913
WI+ +Y T+ T IEV G +R TL+A D + P I V+P G +YWSD
Sbjct: 1830 WISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSD 1889
Query: 914 WGAS---PC-IERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLD 969
G P I A+MDG + K L G + + LD+ ++YW G IE N+D
Sbjct: 1890 QGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVD 1949
Query: 970 GTGRTKLIENLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTL------------ 1017
GT R L+ L HP+G+ ++ +++TD + I+ +K TGA + L
Sbjct: 1950 GTDRMILVHQLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGLQV 2009
Query: 1018 -----------GCGKNNGGCSHLCLLKPGGR-SCACPIGIKLNKDGKTCADGPINYLIFA 1065
GC N C +CL PGG SCAC G KLN D ++C+ P N I
Sbjct: 2010 YHRRNAAESSNGCSNNMNACQQICLPVPGGLFSCACATGFKLNPDNRSCS--PYNSFIVV 2067
Query: 1066 HRVD-IRVISLDVPYLIDVVLPLPPL-KNALGVDVDHSTGLIYWTD-----TGQRKIQRA 1118
+ IR SL++ + ++P+ +NAL VDVD S+G IYW D I+R
Sbjct: 2068 SMLSAIRGFSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASDNAIRRI 2127
Query: 1119 TRLGTHVETVIGNGL--HTADGIVIDSTGRKIYWTDG--GRNSIEVAELDGRNRKVLVWT 1174
G+ + ++ +G+ + GI +D +Y+T+ IEV ++ R+VL+
Sbjct: 2128 KPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKV 2187
Query: 1175 GLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGR 1234
+D PR I + + Y+FW+D+G KIER+ +D NR V+V I P GLA+DR +G
Sbjct: 2188 TVDMPRHIVVDPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGY 2247
Query: 1235 LYWNDAKILTIESSDFDGHDRRTVL--SNVPYPYGIVIVGQHIYWTDWKTKALHRADKT- 1291
+YW D + I +G + + S P PYGI + I W D K + +A K
Sbjct: 2248 VYWVDDSLDIIARIRINGENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKKIFQASKEP 2307
Query: 1292 -NASDPIVIRKNLEGLMDIRAIQSE-------RVLENACGTDNGGCSHLCLRSPLGYTCA 1343
N P VIR N+ L D+ + V N C +NGGCSHLC P +T
Sbjct: 2308 ENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFALPGLHTPK 2367
Query: 1344 CPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTI- 1402
C T K C E FLIFA S+ + L+ PE V+ T+
Sbjct: 2368 CDCAF----GTLQSDGKNCAISTENFLIFALSNSLRSLHLD-PENHSPPFQTINVERTVM 2422
Query: 1403 AVDYHWDLKMIFYTDLDLNVIRSINMTNMSE---SKTIISQKLETPNGLGVDWIANNIYW 1459
++DY I++T + + I+ +S + T+I+ + T +G+ DWI IY+
Sbjct: 2423 SLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRIYY 2482
Query: 1460 TDNEHKVIEVARLDGSSRKVLITGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQ 1519
+D +++I DGS+R V I + +PRA+ L P +GYLYW+DW H IER+ L G+
Sbjct: 2483 SDYLNQMINSMAEDGSNRTV-IARVPKPRAIVLDPCQGYLYWADWDTHAKIERATLGGNF 2541
Query: 1520 RQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQLVPDAKNPFGMTQF 1579
R IV L P+GLT+DY+E LYW DA RI+ S L G R +V A + FG+T +
Sbjct: 2542 RVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAVHAFGLTLY 2601
Query: 1580 KDYIYWTDWYKKSIIRADKRTGKNITLIRTN-LEMAMEIK-AVSADRQHGWNPCKESNGG 1637
YIYWTD Y + I RA+K G + TN L I V +Q NPC++ NGG
Sbjct: 2602 GQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNNPCEQFNGG 2661
Query: 1638 CSHLCLFRGHEYICACPDDPDHVECSTVKMLRNYRDTELKDEEFSNSTGHISFHNPNYSC 1697
CSH+C + C CP + + + K F+ S G + + C
Sbjct: 2662 CSHICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGRCI--SEEWKC 2719
Query: 1698 ATGGPGGNGPDHIE 1711
G+G D +E
Sbjct: 2720 DNDNDCGDGSDEME 2733
Score = 387 bits (953), Expect = e-106
Identities = 279/874 (31%), Positives = 393/874 (44%), Gaps = 67/874 (7%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
CI+ W+CD DNDCGD SDE NC+ +T P+ +
Sbjct: 1121 CISKNWVCDTDNDCGDGSDEKNCNSTET-----------------CQPSQFNCPNHRCID 1163
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWT 292
+ + K +D + N +CA D KC+ +CDG DC D +
Sbjct: 1164 LSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGD------KCIGVTNRCDGVFDCSDNS 1217
Query: 293 DEDSCP-MVPGSCNAGEFKC-NDGKCIPERWRCDNERDCADGGDELN-CKPNSIRNCSLD 349
DE CP PG C++ EF+C DG CIP W CD DC G DE N C P + C
Sbjct: 1218 DEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVP---KTCPSS 1274
Query: 350 EYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRK 409
+ C + C+ + WLCD DC + DE +C + C P CVN
Sbjct: 1275 YFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPT----QPFRC-PSWQWQCLGHNICVNLS 1329
Query: 410 HVCDGMKDCPRGDDEERCPLKRKCS-AEEKCEKLCITTYDGHAACACPMGFLLAEDKYSC 468
VCDG+ DCP G DE CS C C+ G A C CP+GFLLA D +C
Sbjct: 1330 VVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHECVQEPFG-AKCLCPLGFLLANDSKTC 1388
Query: 469 RDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLF---SNRI 525
DIDEC + CSQ C N GSFRC C TGY+L D R+CK T LL N+I
Sbjct: 1389 EDIDEC--DILGSCSQHCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKI 1446
Query: 526 GIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRW 585
V N S+V+ VA+D+ +FWS+ A N + V
Sbjct: 1447 IADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDS 1506
Query: 586 GLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHP--GDA 643
+ +A+DW+ L+WTD +EV+ +DGS R VL++ +L PR +A+ P +
Sbjct: 1507 SIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEH 1566
Query: 644 LVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAA 703
L+FW+DWG +P+IERA MDG R ++ D+IFWP GLTIDY +Y+ D+ ++
Sbjct: 1567 LLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCD 1626
Query: 704 FDGRDRRKVTTKGL--PHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVP 761
++G RR+V L HP+ALTLF+D++YWTD T+ + NK G V + P
Sbjct: 1627 YNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWP 1686
Query: 762 MDIHSRSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSN 821
+ I + + P + A + L L S+ P V P S L+ + +
Sbjct: 1687 LGIVAVHPSKQPNSVNPCAFSRCSHLCLLSSQGP-HFYSCVCPSGWSLSPDLLNC-LRDD 1744
Query: 822 SIFWTDVEKDTINRAYLN---GSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEV 878
F V + I LN S+ + + + + FD IYW + I
Sbjct: 1745 QPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVE-NPGEIHR 1803
Query: 879 SKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGG--NRKKLIFG 936
K+DG+ RT+ A + P + +S + IE + G RK LI
Sbjct: 1804 VKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIAN 1863
Query: 937 QMT-----WPNGLALDLVHNRIYWTDGGNKT-----IEYANLDGTG-RTKLIENLPH--P 983
T +P G+ +D ++YW+D G + I AN+DGT +T NL H
Sbjct: 1864 DGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLEC 1923
Query: 984 FGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTL 1017
LD+ +++W I+ N D G R L
Sbjct: 1924 VTLDIEEQKLYWAVTGRGVIERGNVD-GTDRMIL 1956
Score = 371 bits (913), Expect = e-101
Identities = 189/519 (36%), Positives = 275/519 (52%), Gaps = 27/519 (5%)
Query: 263 CAEIDFECKNTK-----CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCI 317
C++ +F C N + C+P+ + CDGD DC D DE+ +C+ EF C G CI
Sbjct: 2948 CSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQ-NCTRRTCSENEFTCGYGLCI 3006
Query: 318 PERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDE 377
P+ +RCD DC D DE C + C +++TC + RC+ KT++CD DC +G DE
Sbjct: 3007 PKIFRCDRHNDCGDYSDERGCL---YQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDE 3063
Query: 378 MNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCS--A 435
+ C + TC P E N C+ +C+ + DC DE+ C + +C +
Sbjct: 3064 LMH--LCHTPEPTCPPHEFKCDNG--RCIEMMKLCNHLDDCLDNSDEKGCGIN-ECHDPS 3118
Query: 436 EEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRC 495
C+ C T C+C G+ L DK +C DIDEC E VCSQ C N +GS+ C
Sbjct: 3119 ISGCDHNCTDTLTSFY-CSCRPGYKLMSDKRTCVDIDECT-EMPFVCSQKCENVIGSYIC 3176
Query: 496 GCMTGYILRPDERSCKPTGE-SPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHY 554
C GY+ PD ++C+ P L+FSNR +R + + G Y +++GL N VALD+
Sbjct: 3177 KCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDR 3236
Query: 555 EKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEV 614
+K ++W + +VI +N N +I L +AVDW+ L+W D+ + V
Sbjct: 3237 VEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFV 3296
Query: 615 ATLDGSKRAVLV-----AND---LDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKR 666
+ L+G R +L AN+ D PR +A+HP ++W DWG I R MDG +
Sbjct: 3297 SDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNK 3356
Query: 667 KTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLF 726
+I ++ WPNG+TIDYT +YWADA IE + +G R V LPHPFA+T+F
Sbjct: 3357 SVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIF 3416
Query: 727 DDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIH 765
+D IYWTDW+T+++ NK G QT+ + P DIH
Sbjct: 3417 EDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIH 3455
Score = 341 bits (839), Expect = 1e-92
Identities = 201/655 (30%), Positives = 338/655 (51%), Gaps = 33/655 (5%)
Query: 1024 GGCSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGPINY--LIFAHRVDIRVISLDVPYL 1080
G C C +PG C C G L + G+ C A+ +IF++ D+ + +
Sbjct: 356 GICDQKCESRPGRHLCHCEEGYILER-GQYCKANDSFGEASIIFSNGRDLLIGDIH-GRS 413
Query: 1081 IDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIV 1140
+++ A+GV + ++WTDT Q K+ G +++ V+ + T + +
Sbjct: 414 FRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLA 473
Query: 1141 IDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSA 1200
+D KIY + N I++ LDG R L+ L PR IA+ GY+F+SDW + +
Sbjct: 474 VDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLS 533
Query: 1201 ---KIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRT 1257
K+ERA MDG+NR+ +V K+ WP G+ +D I R+YW D++ IE+ +DG R+T
Sbjct: 534 GEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKT 593
Query: 1258 VL---SNVPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQS 1314
V+ S +P+P+G+ + +++TDW A+ +A+K ++P V + + S
Sbjct: 594 VVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHS 653
Query: 1315 ER--VLENACGTDNGGCSHLCLRSP------LGYTCACPTGMPFEKSTTDQTPKKCKSHP 1366
R N C +NGGC +C+ S LG+ C C G + TD+ + C +
Sbjct: 654 LRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLD---TDE--RHCIA-V 707
Query: 1367 EEFLIFATRGSITYISLESPEQWDVTLPVKEVKNT-IAVDYHWDLKMIFYTDLDLNVIRS 1425
+ FLIF+++ +I I Q DV +PV + + +D+ IF++D+ ++I
Sbjct: 708 QNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFK 767
Query: 1426 INMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITGLT 1485
+ + + + ++E L DWI+ N+YWTD+ +K I V RL +R+ ++ L
Sbjct: 768 QKIDGTGR-EILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVVQYLN 826
Query: 1486 EPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYW 1545
PR++ + P GYL+++DW I R++ DGS ++ LG+PNGL ID+ RLYW
Sbjct: 827 NPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYW 886
Query: 1546 TDALKDRIDTSDLNGQHRVQL--VPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKN 1603
DA D+I+ S +G R +L + +PFG+ F +++++TDW +IIR K G
Sbjct: 887 VDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGE 946
Query: 1604 ITLIRTNLEMAMEIKAVSADRQHGWNPCKE---SNGGCSHLCL-FRGHEYICACP 1654
+T+IR+ + + +K+ + Q G N C + NG CSH C + +C CP
Sbjct: 947 MTVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCP 1001
Score = 334 bits (820), Expect = 2e-90
Identities = 195/618 (31%), Positives = 314/618 (50%), Gaps = 49/618 (7%)
Query: 774 EKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTI 833
E ++++ +DL + + + S +++ + AV + + +FWTD ++ +
Sbjct: 393 EASIIFSNGRDLLIGDIHGR----SFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKV 448
Query: 834 NRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDH 893
+NG + +++ ++ P LA DW+ +KIY + NRI++ DGS R L ++
Sbjct: 449 FSVDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITEN 508
Query: 894 IDKPRDIVVNPEGGVMYWSDW---GASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVH 950
+ PR I V+P G +++SDW P +ERA MDG NRK L+ ++ WP G+ LD++
Sbjct: 509 LGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMIS 568
Query: 951 NRIYWTDGGNKTIEYANLDGTGRTKLIEN---LPHPFGLDLYGDEVFWTDWDTQSIQAAN 1007
R+YW D IE DG R ++ +PHPFG+ L+ +VF+TDW ++ AN
Sbjct: 569 KRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKAN 628
Query: 1008 KDTG--------AKRRTLG---------------CGKNNGGCSHLCLLKPG------GRS 1038
K T A R G C NNGGC +C+L G
Sbjct: 629 KFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFR 688
Query: 1039 CACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKN-ALGVD 1097
C C G +L+ D + C N+LIF+ +V IR I + DV++P+ + +G+D
Sbjct: 689 CKCTFGFQLDTDERHCI-AVQNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGID 747
Query: 1098 VDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNS 1157
D I+++D + I + GT E + N + + + D + +YWTD S
Sbjct: 748 FDAQDSTIFFSDMSKHMIFKQKIDGTGREILAANRVENVESLAFDWISKNLYWTDSHYKS 807
Query: 1158 IEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVD 1217
I V L + R+ +V L++PR++ +H GY+F++DW AKI RA DG++ +++
Sbjct: 808 ISVMRLADKTRRTVV-QYLNNPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVIN 866
Query: 1218 NKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTV--LSNVPYPYGIVIVGQHI 1275
+ WPNGLAID RLYW DA IE S FDG DRR + + + +P+G+ I G+H+
Sbjct: 867 TTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHL 926
Query: 1276 YWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQ-SERVLENACGT---DNGGCSH 1331
++TDW+ A+ R K + + VIR + ++ +++ + + NAC NG CSH
Sbjct: 927 FFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSH 986
Query: 1332 LCLRSP-LGYTCACPTGM 1348
C P C CP GM
Sbjct: 987 FCFPVPNFQRVCGCPYGM 1004
Score = 315 bits (773), Expect = 1e-84
Identities = 179/513 (34%), Positives = 263/513 (51%), Gaps = 33/513 (6%)
Query: 259 ELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCP-MVPGS--CNAGEFKCNDGK 315
E+ C F+C + CV + +CDG DC D +DE CP P C A F+C +
Sbjct: 3794 EMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKNHV 3853
Query: 316 CIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGE 375
CIP W+CD + DC DG DE + S + + C + RC+ +C+GV DC +G
Sbjct: 3854 CIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDGT 3913
Query: 376 DEMNCEVSCEE-DQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPL-KRKC 433
DE E C + C E+ N +C+ +VCD DC DE C K +
Sbjct: 3914 DE--TEEHCRKPTPKPCTEYEYKCGNG--HCIPHDNVCDDADDCGDWSDELGCNKGKERT 3969
Query: 434 SAEEKCEKLCITTYDGHAACACPMGF-LLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGS 492
AE CE+ C +G C+C GF D+ SC DI+EC EQ C Q C NT GS
Sbjct: 3970 CAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINEC--EQFGTCPQHCRNTKGS 4027
Query: 493 FRCGCMTGYILRPDE--RSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVAL 550
+ C C G+ D + C G SP LL + + IR+ L+ + + ++ A+
Sbjct: 4028 YECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQDEEYIQAV 4087
Query: 551 DYHYEKK-----LVFWS----ENNLRVIRVA-----QMNTKNMSDVIRWGLE---TPAGV 593
DY ++ K +V+++ + I+ A + N+ + L+ P G+
Sbjct: 4088 DYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGI 4147
Query: 594 AVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPN 653
AVDW+ ++W+D +R+EVA LDG R L++ DLD+P AIAV+P L+FWTDWG
Sbjct: 4148 AVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKE 4207
Query: 654 PKIERADMDGDKRKTVIYDEIFWPNGLTIDY-TESKIYWADAKHHVIERAAFDGRDRRKV 712
PKIE A M+G+ R ++++++ WP GL+IDY +IYW+D K VIE +DG DRR V
Sbjct: 4208 PKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRR-V 4266
Query: 713 TTKGLPHPFALTLFDDAIYWTDWHTKSISTVNK 745
K +P++L +F+D +YW + NK
Sbjct: 4267 IAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNK 4299
Score = 313 bits (768), Expect = 4e-84
Identities = 164/493 (33%), Positives = 259/493 (52%), Gaps = 28/493 (5%)
Query: 270 CKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDC 329
C N C +CD DC D +DE +C + C EF C +G+CIP + CD++ DC
Sbjct: 152 CDNGACYNTSQKCDWKVDCRDSSDEINCTEI---CLHNEFSCGNGECIPRAYVCDHDNDC 208
Query: 330 ADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQY 389
DG DE C + C ++TC RC+ + W+CDG DC + DE CE S D +
Sbjct: 209 QDGSDEHAC---NYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCE-SGPHDVH 264
Query: 390 TCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCS----AEEKCEKLCIT 445
C P+E + R C++ VCDG+ DCP +DE + CS + C+ C
Sbjct: 265 KCSPREWSCPESGR-CISIYKVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQYQCHE 323
Query: 446 TYDGHAACACPMGFLLAE-DKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILR 504
T G AC CP G+++ D +C + D+C +C Q C + G C C GYIL
Sbjct: 324 TPYG-GACFCPPGYIINHNDSRTCVEFDDCQIWG--ICDQKCESRPGRHLCHCEEGYILE 380
Query: 505 PDERSCKPT---GESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALD--YHYEKKLV 559
+ CK GE+ +++FSN + + G ++ +V+ + VA+ +HY + V
Sbjct: 381 RGQY-CKANDSFGEA-SIIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYHLQRV 438
Query: 560 FWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDG 619
FW++ + +N N+ +V+ +ETP +AVDW+++ ++ ++ R+++ LDG
Sbjct: 439 FWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDG 498
Query: 620 SKRAVLVANDLDKPRAIAVHPGDALVFWTDW---GPNPKIERADMDGDKRKTVIYDEIFW 676
S R L+ +L PR IAV P +F++DW PK+ERA MDG RK ++ ++ W
Sbjct: 499 SYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGW 558
Query: 677 PNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKG--LPHPFALTLFDDAIYWTD 734
P G+T+D ++YW D++ IE +DG R+ V G +PHPF ++LF+ +++TD
Sbjct: 559 PAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTD 618
Query: 735 WHTKSISTVNKNT 747
W ++ NK T
Sbjct: 619 WTKMAVLKANKFT 631
Score = 291 bits (713), Expect = 2e-77
Identities = 258/974 (26%), Positives = 414/974 (42%), Gaps = 108/974 (11%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEI-NCDVVK-TSLLVPSANASLNIGDVITNPTVLI 224
C S CI W+CD D DC D SDE +C +S + +N + +
Sbjct: 74 CQSEGQCIPSSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDC 133
Query: 225 ALTKPTVVIRYESFCAKKALDNAA----NPRSTWN----QPVELMRCAEI----DFECKN 272
+Y + C + DN A + + W + + C EI +F C N
Sbjct: 134 PDGADENDCQYPT-CEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGN 192
Query: 273 TKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADG 332
+C+P+ + CD DNDC D +DE +C +C +F C G+CI + W CD E DC D
Sbjct: 193 GECIPRAYVCDHDNDCQDGSDEHACNYP--TCGGYQFTCPSGRCIYQNWVCDGEDDCKDN 250
Query: 333 GDELNCK--PNSIRNCSLDEYTCADR-RCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQY 389
GDE C+ P+ + CS E++C + RC+ +CDG+ DC EDE N
Sbjct: 251 GDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMT 310
Query: 390 TCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRG-----DDEERCPLKRKCSAEEKCEKLCI 444
C N C + G CP G +D C C C++ C
Sbjct: 311 LCSAL-----NCQYQCHETPY--GGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKC- 362
Query: 445 TTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILR 504
+ G C C G++L +Y C+ D E + S +G G ++
Sbjct: 363 ESRPGRHLCHCEEGYILERGQY-CKANDS-FGEASIIFSNGRDLLIGDIH-GRSFRILVE 419
Query: 505 PDERSCKPTGESPTLLFSNRIGIRQVWL--TGDNYMSV-VKGLHNAVALDYHYEKK---L 558
R G + + F + R W + SV + GL+ L+ E
Sbjct: 420 SQNR-----GVAVGVAFHYHLQ-RVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLA 473
Query: 559 VFWSENNLRVI--RVAQMNTKNMSDVIRWGLET-----PAGVAVDWIHDLLFWTD----S 607
V W N + ++ +V +++ N+ R L T P G+AVD LF++D S
Sbjct: 474 VDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLS 533
Query: 608 GTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRK 667
G ++E A +DGS R LV L P + + V+W D IE DG +RK
Sbjct: 534 GEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVD-SRFDYIETVTYDGIQRK 592
Query: 668 TVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFD 727
TV++ P+ + E ++++ D + +A +V + P+ +T++
Sbjct: 593 TVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYH 652
Query: 728 DAI--YWTDWHTKS---------ISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKL 776
Y T+ + +S N G+G + +D R C +
Sbjct: 653 SLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFRC-KCTFGFQLDTDERHCIAV-QNF 710
Query: 777 LLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSA-VALDWDQKSNSIFWTDVEKDTINR 835
L+++ + +R D+++PV S V +D+D + ++IF++D+ K I +
Sbjct: 711 LIFSSQVAIRGIPFTLST---QEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFK 767
Query: 836 AYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSK-SDGSMRTLLAWDHI 894
++G+ + + + + LAFDWI+ +YWTD I V + +D + RT++ ++
Sbjct: 768 QKIDGTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV--QYL 825
Query: 895 DKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIY 954
+ PR +VV+P G ++++DW I RA DG + +I + WPNGLA+D +R+Y
Sbjct: 826 NNPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLY 885
Query: 955 WTDGGNKTIEYANLDGTGRTKL--IENLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGA 1012
W D IE++ DG R +L IE + HPFGL ++G+ +F+TDW +I K G
Sbjct: 886 WVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGG 945
Query: 1013 KRRTLGCG-------------------------KNNGGCSHLCLLKPG-GRSCACPIGIK 1046
+ + G NG CSH C P R C CP G++
Sbjct: 946 EMTVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMR 1005
Query: 1047 LNKDGKTCADGPIN 1060
L + TC P N
Sbjct: 1006 LASNHLTCEGDPTN 1019
Score = 242 bits (593), Expect = 7e-63
Identities = 126/335 (37%), Positives = 183/335 (54%), Gaps = 18/335 (5%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPI--NYLIFAHRVDIRVISLDVPYLIDV 1083
CS C G C C G DGKTC YLIF++R +R +++D Y +
Sbjct: 3163 CSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTID-GYFYSL 3221
Query: 1084 VLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDS 1143
+L L N + +D D +YW DT ++ I+R T+ ET+I + L A+ + +D
Sbjct: 3222 ILE--GLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDW 3279
Query: 1144 TGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDS--------PRAIALHYEYGYMFWSD 1195
RK+YW D + + V++L+G +R++L +D+ PR +ALH +YGY++W+D
Sbjct: 3280 VSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWAD 3339
Query: 1196 WGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDR 1255
WG A I R MDG N+ VI+ K++WPNG+ ID LYW DA + IE SD +GH R
Sbjct: 3340 WGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHR 3399
Query: 1256 RTVLSN-VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQS 1314
TV +P+P+ I I IYWTDW T+ + + +K + S+ + DI
Sbjct: 3400 HTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHP 3459
Query: 1315 ER--VLENACGTDNGGCSHLCLRSP--LGYTCACP 1345
R ++ N CGT+NGGCSHLCL P G+TC CP
Sbjct: 3460 YRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECP 3494
Score = 205 bits (501), Expect = 1e-51
Identities = 115/341 (33%), Positives = 177/341 (51%), Gaps = 20/341 (5%)
Query: 1329 CSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQ 1388
CS C Y C C G + + +T ++ S+ E +LIF+ R + ++++
Sbjct: 3163 CSQKCENVIGSYICKCAPG--YLREPDGKTCRQ-NSNIEPYLIFSNRYYLRNLTIDG--- 3216
Query: 1389 WDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGL 1448
+ +L ++ + N +A+D+ K +++ D VI + + N + +TII+ +L L
Sbjct: 3217 YFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFL-NKTNKETIINHRLPAAESL 3275
Query: 1449 GVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITGLTE---------PRALALFPAKGYL 1499
VDW++ +YW D + V+ L+G R++L + PR LAL P GYL
Sbjct: 3276 AVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYL 3335
Query: 1500 YWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLN 1559
YW+DWG YI R +DG+ + +I+ L +PNG+TIDY LYW DA I+ SDL
Sbjct: 3336 YWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLE 3395
Query: 1560 GQHRVQLVPDA-KNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIK 1618
G HR + A +PF +T F+D IYWTDW +++ + +K G N + +I
Sbjct: 3396 GHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIH 3455
Query: 1619 AVSADRQH-GWNPCKESNGGCSHLCLFR--GHEYICACPDD 1656
RQ NPC +NGGCSHLCL + G + C CPDD
Sbjct: 3456 VYHPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPDD 3496
Score = 200 bits (488), Expect = 4e-50
Identities = 98/281 (34%), Positives = 157/281 (55%), Gaps = 34/281 (12%)
Query: 796 IDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPA 855
ID + +E + + VALD+D+ ++W D ++ I R +LN +++ TI++ L
Sbjct: 3214 IDGYFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAE 3273
Query: 856 GLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHID--------KPRDIVVNPEGG 907
LA DW++ K+YW D + + VS +G R +LA +D PR + ++P+ G
Sbjct: 3274 SLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYG 3333
Query: 908 VMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYAN 967
+YW+DWG I R MDG N+ +I ++ WPNG+ +D ++ +YW D IEY++
Sbjct: 3334 YLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSD 3393
Query: 968 LDGTGRTKLIEN-LPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTL--------- 1017
L+G R + + LPHPF + ++ D ++WTDW+T++++ NK G+ R+TL
Sbjct: 3394 LEGHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFD 3453
Query: 1018 --------------GCGKNNGGCSHLCLLKPGGR--SCACP 1042
CG NNGGCSHLCL+KPGG+ +C CP
Sbjct: 3454 IHVYHPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECP 3494
Score = 183 bits (446), Expect = 4e-45
Identities = 118/361 (32%), Positives = 181/361 (50%), Gaps = 30/361 (8%)
Query: 1327 GGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEE-FLIFATRGSITYISLES 1385
G C C + Y C C G S +D+ K+C + L+ I +L S
Sbjct: 4015 GTCPQHCRNTKGSYECVCADGFT---SMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSS 4071
Query: 1386 PEQWDVTLPVKEVKNTIAVDYHWD-----LKMIFYT----DLDLNVIRSINMTNMSESKT 1436
E++ L +E AVDY WD L +++YT I+ + N +
Sbjct: 4072 -ERFSEYLQDEEYIQ--AVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRN 4128
Query: 1437 IISQKLET-------PNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLI-TGLTEPR 1488
+ Q+++ P+G+ VDW+ +IYW+D ++K IEVA+LDG RK LI T L +P
Sbjct: 4129 NLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPA 4188
Query: 1489 ALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDY-KERRLYWTD 1547
A+A+ P G ++W+DWG+ P IE ++++G R I+V DLG+P GL+IDY R+YW+D
Sbjct: 4189 AIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSD 4248
Query: 1548 ALKDRIDTSDLNGQHRVQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADK--RTGKNIT 1605
+D I+T +G R + +A NP+ + F+D +YW K + + +K + K T
Sbjct: 4249 FKEDVIETIKYDGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKT 4308
Query: 1606 LIRTNLEMAMEIKAVSADRQHGWNPCKESNGGCSHLCLFRGHEYICACPDDPDHVECSTV 1665
L+ + I + N CK+ CSHLCL R Y CACP +E ST
Sbjct: 4309 LVVNPWLTQVRIFHQLRYNKSVPNLCKQI---CSHLCLLRPGGYSCACPQGSSFIEGSTT 4365
Query: 1666 K 1666
+
Sbjct: 4366 E 4366
Score = 180 bits (439), Expect = 3e-44
Identities = 143/504 (28%), Positives = 223/504 (44%), Gaps = 54/504 (10%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPG-SCNAGEFKC-----NDGKC 316
C +F+C +C+P ++ CDGDNDCGD +DED +C+ EF C D +C
Sbjct: 2906 CLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRC 2965
Query: 317 IPERWRCDNERDCADGGDE-LNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGE 375
IP+ W CD + DC DG DE NC + R CS +E+TC C+ K + CD DC +
Sbjct: 2966 IPQSWVCDGDVDCTDGYDENQNC---TRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYS 3022
Query: 376 DEMNC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE--ERCPL-KR 431
DE C +C+++Q+TC+ N C+++ VCD DC G DE C +
Sbjct: 3023 DERGCLYQTCQQNQFTCQ-------NG--RCISKTFVCDEDNDCGDGSDELMHLCHTPEP 3073
Query: 432 KCSAEE-KCEK-LCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNT 489
C E KC+ CI + C L D+ C I+EC C C++T
Sbjct: 3074 TCPPHEFKCDNGRCI---EMMKLCNHLDDCLDNSDEKGC-GINECHDPSISGCDHNCTDT 3129
Query: 490 VGSFRCGCMTGYILRPDERSCKPTGESPTLLF------SNRIGIRQVWLTGDNYMSVVKG 543
+ SF C C GY L D+R+C E + F N IG + Y+ G
Sbjct: 3130 LTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIG-SYICKCAPGYLREPDG 3188
Query: 544 LHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLF 603
+ + E L+F + LR + + +I GL+ + D + L+
Sbjct: 3189 --KTCRQNSNIEPYLIFSNRYYLRNLTI----DGYFYSLILEGLDNVVALDFDRVEKRLY 3242
Query: 604 WTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDG 663
W D+ + +E L+ + + ++ + L ++AV ++W D + +D++G
Sbjct: 3243 WIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLD-ARLDGLFVSDLNG 3301
Query: 664 DKRK-----TVIYDEIFW---PNGLTIDYTESKIYWADAKHHV-IERAAFDGRDRRKVTT 714
R+ V + F P GL + +YWAD H I R DG ++ + +
Sbjct: 3302 GHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIIS 3361
Query: 715 KGLPHPFALTL--FDDAIYWTDWH 736
L P +T+ +D +YW D H
Sbjct: 3362 TKLEWPNGITIDYTNDLLYWADAH 3385
Score = 172 bits (419), Expect = 8e-42
Identities = 121/357 (33%), Positives = 171/357 (47%), Gaps = 29/357 (8%)
Query: 1024 GGCSHLCLLKPGGRSCACPIGIKLNKD--GKTCA-DGPINYLIFAHRVDIRVISLDVPYL 1080
G C C G C C G D GK CA +G L+ V IR +L
Sbjct: 4015 GTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERF 4074
Query: 1081 IDVVLPLPPLKNALGVDVD-HSTGL--IYWTDTGQRK----IQRA---------TRLGTH 1124
+ + ++ A+ D D GL +Y+T G+ I+RA L
Sbjct: 4075 SEYLQDEEYIQ-AVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQE 4133
Query: 1125 VETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIAL 1184
V+ + + DGI +D GR IYW+D IEVA+LDGR RK L+ T LD P AIA+
Sbjct: 4134 VDLKLKYVMQP-DGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAV 4192
Query: 1185 HYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEG-RLYWNDAKIL 1243
+ + G MFW+DWG KIE A M+G +R ++V + WP GL+ID + R+YW+D K
Sbjct: 4193 NPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKED 4252
Query: 1244 TIESSDFDGHDRRTVLSNVPYPYGIVIVGQHIYWTDWKTKALHRADK---TNASDPIVIR 1300
IE+ +DG DRR + PY + I +YW + + + +K +V+
Sbjct: 4253 VIETIKYDGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVN 4312
Query: 1301 KNLEGLMDIRAIQSERVLENACGTDNGGCSHLCLRSPLGYTCACPTGMPF-EKSTTD 1356
L + ++ + + N C CSHLCL P GY+CACP G F E STT+
Sbjct: 4313 PWLTQVRIFHQLRYNKSVPNLC---KQICSHLCLLRPGGYSCACPQGSSFIEGSTTE 4366
Score = 167 bits (407), Expect = 2e-40
Identities = 161/628 (25%), Positives = 263/628 (41%), Gaps = 73/628 (11%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
+ CD R C S + CI +W CDG DC D +DEI C VV + G
Sbjct: 26 QECDSAHFR--CGSGH-CIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSE---GQ 79
Query: 216 VITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKC 275
I + + V + C D+ ++ R +Q C+ C N +C
Sbjct: 80 CIPS----------SWVCDQDQDC-----DDGSDERQDCSQST----CSSHQITCSNGQC 120
Query: 276 VPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDE 335
+P +++CD DC D DE+ C P +C + C++G C +CD + DC D DE
Sbjct: 121 IPSEYRCDHVRDCPDGADENDC-QYP-TCE--QLTCDNGACYNTSQKCDWKVDCRDSSDE 176
Query: 336 LNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV-SCEEDQYTCRPQ 394
+NC + N E++C + C+ + ++CD DC +G DE C +C Q+TC P
Sbjct: 177 INCTEICLHN----EFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTC-PS 231
Query: 395 EHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPL----KRKCSAEE-KCEK--LCITTY 447
C+ + VCDG DC DE+ C KCS E C + CI+ Y
Sbjct: 232 --------GRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIY 283
Query: 448 DGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV--CSQTCSNTVGSFRCGCMTGYIL-R 504
C + ED+ + C C C T C C GYI+
Sbjct: 284 ---KVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYIINH 340
Query: 505 PDERSCKPTGESP-----TLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLV 559
D R+C + +R G R + + Y+ + +G + A D E ++
Sbjct: 341 NDSRTCVEFDDCQIWGICDQKCESRPG-RHLCHCEEGYI-LERGQY-CKANDSFGEASII 397
Query: 560 FWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDG 619
F + +L + + + + + + G+ GVA + +FWTD+ +V ++G
Sbjct: 398 FSNGRDLLIGDIHGRSFRILVESQNRGV--AVGVAFHYHLQRVFWTDTVQNKVFSVDING 455
Query: 620 SKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNG 679
++ ++ P +AV + ++ + N +I+ ++DG R T+I + + P G
Sbjct: 456 LNIQEVLNVSVETPENLAVDWVNNKIYLVETKVN-RIDMVNLDGSYRVTLITENLGHPRG 514
Query: 680 LTIDYTESKIYWAD----AKHHVIERAAFDGRDRRK-VTTK-GLPHPFALTLFDDAIYWT 733
+ +D T ++++D + +ERA DG +R+ V TK G P L + +YW
Sbjct: 515 IAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWV 574
Query: 734 DWHTKSISTVNKNTGMGIQTVHAGLNVP 761
D I TV + VH G +P
Sbjct: 575 DSRFDYIETVTYDGIQRKTVVHGGSLIP 602
Score = 167 bits (407), Expect = 2e-40
Identities = 82/227 (36%), Positives = 116/227 (51%), Gaps = 20/227 (8%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
+C F CKN +CVP + CDG +DC D +DE C + +C++ F C G+CIP W
Sbjct: 1025 QCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHW 1084
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCE 381
RCD DC DG DE NC ++ +C +YTC + +C+ K W+CD DC +G DE NC
Sbjct: 1085 RCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCN 1144
Query: 382 VSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPL-----KRKCSAE 436
S E TC+P + N C++ VCDG KDC G DE C L + KC++
Sbjct: 1145 -STE----TCQPSQFNCPN--HRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASG 1197
Query: 437 EKC---EKLCITTYD-----GHAACACPMGFLLAEDKYSCRDIDECM 475
+KC C +D A C + D++ C++ C+
Sbjct: 1198 DKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICI 1244
Score = 160 bits (389), Expect = 4e-38
Identities = 87/228 (38%), Positives = 121/228 (53%), Gaps = 22/228 (9%)
Query: 854 PAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSD 913
P G+A DW+ IYW+D RIEV+K DG R L +D+P I VNP+ G+M+W+D
Sbjct: 4144 PDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTD 4203
Query: 914 WGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHN-RIYWTDGGNKTIEYANLDGTG 972
WG P IE A M+G +R L+F + WP GL++D ++N RIYW+D IE DGT
Sbjct: 4204 WGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTD 4263
Query: 973 RTKLIENLPHPFGLDLYGDEVFWTDWDTQSIQAANK-DTGAKRRTLGCG----------- 1020
R + + +P+ LD++ D+++W + + NK G K +TL
Sbjct: 4264 RRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFHQ 4323
Query: 1021 -KNNGG--------CSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPI 1059
+ N CSHLCLL+PGG SCACP G + T D I
Sbjct: 4324 LRYNKSVPNLCKQICSHLCLLRPGGYSCACPQGSSFIEGSTTECDAAI 4371
Score = 152 bits (368), Expect = 1e-35
Identities = 138/518 (26%), Positives = 214/518 (41%), Gaps = 56/518 (10%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C E +F C N +C+P + CD NDCGD +DE C M +C+ F+C G C+ +
Sbjct: 3759 CTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEM--RTCHPEYFQCTSGHCVHSELK 3816
Query: 323 CDNERDCADGGDELNCKPNSIRN---CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMN 379
CD DC D DE +C P + C + C + C+ W CDG DC +G DE
Sbjct: 3817 CDGSADCLDASDEADC-PTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDE-- 3873
Query: 380 CEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDD--EERC--PLKRKCSA 435
E+ D P N C+ VC+G+ DC G D EE C P + C+
Sbjct: 3874 -ELHLCLDVPCNSPNRFRCDN--NRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTE 3930
Query: 436 -EEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSN-TVGSF 493
E KC +D A G D+ C E ++ +C Q C+ G F
Sbjct: 3931 YEYKCGNGHCIPHDNVCDDADDCGDW--SDELGCNKGKERTCAEN-ICEQNCTQLNEGGF 3987
Query: 494 RCGCMTGYILRPDERS-------CKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHN 546
C C G+ +R+ C+ G P + + V G MS G
Sbjct: 3988 ICSCTAGFETNVFDRTSCLDINECEQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRC 4047
Query: 547 AVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIH-----DL 601
A + +N+R IR ++++ S+ ++ E V DW +
Sbjct: 4048 AAE-----GSSPLLLLPDNVR-IRKYNLSSERFSEYLQ-DEEYIQAVDYDWDPKDIGLSV 4100
Query: 602 LFWTDSG-------TRRVEVATLDGSKRAVLVANDLD-----KPRAIAVHPGDALVFWTD 649
+++T G +R + + + ++ DL +P IAV ++W+D
Sbjct: 4101 VYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSD 4160
Query: 650 WGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWAD-AKHHVIERAAFDGRD 708
N +IE A +DG RK +I ++ P + ++ ++W D K IE A +G D
Sbjct: 4161 -VKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGED 4219
Query: 709 RRKVTTKGLPHPFALT---LFDDAIYWTDWHTKSISTV 743
R + + L P L+ L +D IYW+D+ I T+
Sbjct: 4220 RNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETI 4257
Score = 150 bits (364), Expect = 4e-35
Identities = 89/269 (33%), Positives = 122/269 (45%), Gaps = 28/269 (10%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
C+ + CD NDCGD SDE C L NA+ +
Sbjct: 2753 CVQYSYRCDYYNDCGDGSDEAGC-------LFRDCNATTEF------------MCNNRRC 2793
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTK-CVPKDFQCDGDNDCGDW 291
I E C +DN + ++ + C +C N+ C+P+ + CDGDNDCGD
Sbjct: 2794 IPREFIC--NGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDN 2851
Query: 292 TDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEY 351
+DE+ +C++ EF+C G+CIP+ W CD E DC D DE +S R C DE+
Sbjct: 2852 SDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEF 2911
Query: 352 TCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSN---AFRNCVNR 408
C RC+ W+CDG DC + DE + C+ C E L N R C+ +
Sbjct: 2912 KCDGGRCIPSEWICDGDNDCGDMSDE-DKRHQCQNQ--NCSDSEFLCVNDRPPDRRCIPQ 2968
Query: 409 KHVCDGMKDCPRGDDEERCPLKRKCSAEE 437
VCDG DC G DE + +R CS E
Sbjct: 2969 SWVCDGDVDCTDGYDENQNCTRRTCSENE 2997
Score = 147 bits (357), Expect = 3e-34
Identities = 87/254 (34%), Positives = 120/254 (47%), Gaps = 27/254 (10%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
CI W CD DNDCGD SDE + +S ++ D N T T +
Sbjct: 3647 CIPQAWKCDVDNDCGDHSDEP----------IEECMSSAHLCD---NFTEFSCKTNYRCI 3693
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEI-DFECKNTKCVPKDFQCDGDNDCGDW 291
++ + C +D+ + ++ Q E C + DF CKN C+P +QCDG NDCGD
Sbjct: 3694 PKW-AVC--NGVDDCRD--NSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDN 3748
Query: 292 TDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEY 351
+DE++C P C EF+C + +CIP RW CD+ DC D DE +C+ +R C + +
Sbjct: 3749 SDEENC--APRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCE---MRTCHPEYF 3803
Query: 352 TCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHV 411
C CV CDG DC + DE +C + Y C+ N C+
Sbjct: 3804 QCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGAY-CQATMFECKN--HVCIPPYWK 3860
Query: 412 CDGMKDCPRGDDEE 425
CDG DC G DEE
Sbjct: 3861 CDGDDDCGDGSDEE 3874
Score = 147 bits (355), Expect = 5e-34
Identities = 116/474 (24%), Positives = 212/474 (44%), Gaps = 34/474 (7%)
Query: 255 NQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDG 314
NQ C+E +F C C+PK F+CD NDCGD++DE C + +C +F C +G
Sbjct: 2985 NQNCTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGC--LYQTCQQNQFTCQNG 3042
Query: 315 KCIPERWRCDNERDCADGGDEL-NCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTN 373
+CI + + CD + DC DG DEL + C E+ C + RC+ LC+ + DC +
Sbjct: 3043 RCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLD 3102
Query: 374 GEDEMNCEVS-CEEDQYT-CRPQ-EHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLK 430
DE C ++ C + + C +++ + +C + + C D +E +
Sbjct: 3103 NSDEKGCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCV--DIDECTEMP 3160
Query: 431 RKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCR---DIDECMYEQDPVCSQTCS 487
CS +KCE + G C C G+L D +CR +I+ + + +
Sbjct: 3161 FVCS--QKCENVI-----GSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNL- 3212
Query: 488 NTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVK-GLHN 546
T+ + + + + + + R I +++L N +++ L
Sbjct: 3213 -TIDGYFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPA 3271
Query: 547 AVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIR--------WGLETPAGVAVDWI 598
A +L + + ++W + L + V+ +N + + + + + P G+A+
Sbjct: 3272 AESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQ 3331
Query: 599 HDLLFWTDSGTRR-VEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIE 657
+ L+W D G R + +DG+ ++V+++ L+ P I + + L++W D IE
Sbjct: 3332 YGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWAD-AHLGYIE 3390
Query: 658 RADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERA-AFDGRDRR 710
+D++G R TV YD P+ I E IYW D +E+ +DG +R+
Sbjct: 3391 YSDLEGHHRHTV-YDGAL-PHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQ 3442
Score = 136 bits (329), Expect = 7e-31
Identities = 64/186 (34%), Positives = 98/186 (52%), Gaps = 11/186 (5%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C +++C N +C+P+ +QCD NDC D +DEDS +C G+F+C +G+CIP+ W+
Sbjct: 3594 CDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWK 3653
Query: 323 CDNERDCADGGDE--LNCKPNSIRNCSLDEYTC-ADRRCVLKTWLCDGVRDCTNGEDEMN 379
CD + DC D DE C ++ + E++C + RC+ K +C+GV DC + DE
Sbjct: 3654 CDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQG 3713
Query: 380 CEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKC 439
CE + TC P +C+ + CDG DC DEE C + +E +C
Sbjct: 3714 CE------ERTCHPVGDFRCKN-HHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRC 3766
Query: 440 -EKLCI 444
+ CI
Sbjct: 3767 VNQQCI 3772
Score = 131 bits (317), Expect = 2e-29
Identities = 101/334 (30%), Positives = 144/334 (43%), Gaps = 46/334 (13%)
Query: 169 STNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTK 228
S CI+ EW CD DNDCGD SDE+ V P+A N G + +
Sbjct: 2708 SNGRCISEEWKCDNDNDCGDGSDEME-SVCALHTCSPTAFTCAN-GRCV----------Q 2755
Query: 229 PTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDC 288
+ Y + C + D A N E M C N +C+P++F C+G ++C
Sbjct: 2756 YSYRCDYYNDCGDGS-DEAGCLFRDCNATTEFM--------CNNRRCIPREFICNGVDNC 2806
Query: 289 GD--WTDEDSCPMVPGSCNAGEFKC-NDGKCIPERWRCDNERDCADGGDELNCKPNSIRN 345
D +DE +CP +C +G KC N CIP + CD + DC D DE N +
Sbjct: 2807 HDNNTSDEKNCP--DRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDE-NPTYCTTHT 2863
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNC 405
CS E+ CA RC+ + W CD DC + DE SC + TC E C
Sbjct: 2864 CSSSEFQCASGRCIPQHWYCDQETDCFDASDE---PASCGHSERTCLADEFKCDGG--RC 2918
Query: 406 VNRKHVCDGMKDCPRGDDEERCPLKRKCSAE--EKCEKLCITTYDGHAACACPMGFLLAE 463
+ + +CDG DC DE++ + +C + E LC+ C P ++
Sbjct: 2919 IPSEWICDGDNDCGDMSDEDK---RHQCQNQNCSDSEFLCVNDRPPDRRC-IPQSWVCDG 2974
Query: 464 DKYSCRDIDECMYEQDPVCS-QTCSNTVGSFRCG 496
D C D Y+++ C+ +TCS F CG
Sbjct: 2975 D-VDCTD----GYDENQNCTRRTCSE--NEFTCG 3001
Score = 128 bits (308), Expect = 2e-28
Identities = 66/174 (37%), Positives = 90/174 (51%), Gaps = 19/174 (10%)
Query: 257 PVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKC-NDGK 315
P C F C + C+P D++CDG DC D DE C +V +C G FKC ++G+
Sbjct: 22 PASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVV--TCQQGYFKCQSEGQ 79
Query: 316 CIPERWRCDNERDCADGGDE-LNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNG 374
CIP W CD ++DC DG DE +C ++ CS + TC++ +C+ + CD VRDC +G
Sbjct: 80 CIPSSWVCDQDQDCDDGSDERQDCSQST---CSSHQITCSNGQCIPSEYRCDHVRDCPDG 136
Query: 375 EDEMNCEV-SCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC 427
DE +C+ +CE Q TC N C N CD DC DE C
Sbjct: 137 ADENDCQYPTCE--QLTC-------DNG--ACYNTSQKCDWKVDCRDSSDEINC 179
Score = 126 bits (303), Expect = 1e-27
Identities = 64/184 (34%), Positives = 95/184 (51%), Gaps = 17/184 (9%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
RC F C N +C+ ++++CD DNDCGD +DE +C+ F C +G+C+ +
Sbjct: 2699 RCGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSY 2758
Query: 322 RCDNERDCADGGDELNCKPNSIRNC-SLDEYTCADRRCVLKTWLCDGVRDC--TNGEDEM 378
RCD DC DG DE C R+C + E+ C +RRC+ + ++C+GV +C N DE
Sbjct: 2759 RCDYYNDCGDGSDEAGC---LFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEK 2815
Query: 379 NC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEE--RCPLKRKCSA 435
NC + +C+ C SN C+ R ++CDG DC DE C S+
Sbjct: 2816 NCPDRTCQSGYTKCH-----NSNI---CIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSS 2867
Query: 436 EEKC 439
E +C
Sbjct: 2868 EFQC 2871
Score = 108 bits (259), Expect = 2e-22
Identities = 52/171 (30%), Positives = 79/171 (46%), Gaps = 4/171 (2%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C F+C + C C+ +C D +DED C++ E++C + +CIPE W+
Sbjct: 3553 CRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQ 3612
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV 382
CD DC D DE + + R C ++ CA+ RC+ + W CD DC + DE E
Sbjct: 3613 CDTFNDCEDNSDE-DSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEE- 3670
Query: 383 SCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKC 433
C + C C+ + VC+G+ DC DE+ C +R C
Sbjct: 3671 -CMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCE-ERTC 3719
Score = 103 bits (247), Expect = 6e-21
Identities = 86/301 (28%), Positives = 119/301 (39%), Gaps = 47/301 (15%)
Query: 166 ICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIA 225
+C + CI + W CDG DC D SDE+ + L + G+ + T+ A
Sbjct: 3518 LCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRL---GQFQCSDGNCTSPQTLCNA 3574
Query: 226 LTK-PTVVIRYESFCAKKALDN----AANPR---STWNQPVELMRCAEIDFE----CKNT 273
P C D+ AN R +W Q C + E C +
Sbjct: 3575 HQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESW-QCDTFNDCEDNSDEDSSHCASR 3633
Query: 274 KCVPKDFQC------------DGDNDCGDWTDE--DSCPMVPGSC-NAGEFKCNDG-KCI 317
C P F+C D DNDCGD +DE + C C N EF C +CI
Sbjct: 3634 TCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCI 3693
Query: 318 PERWRCDNERDCADGGDELNCKPNSIRNC-SLDEYTCADRRCVLKTWLCDGVRDCTNGED 376
P+ C+ DC D DE C+ R C + ++ C + C+ W CDG DC + D
Sbjct: 3694 PKWAVCNGVDDCRDNSDEQGCEE---RTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSD 3750
Query: 377 EMNCEV-SCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSA 435
E NC C E ++ C Q+ C+ + +CD DC DE C + R C
Sbjct: 3751 EENCAPRECTESEFRCVNQQ---------CIPSRWICDHYNDCGDNSDERDCEM-RTCHP 3800
Query: 436 E 436
E
Sbjct: 3801 E 3801
Score = 90.2 bits (214), Expect = 6e-17
Identities = 73/277 (26%), Positives = 113/277 (40%), Gaps = 44/277 (15%)
Query: 254 WNQPVELMRCAEIDFECKNTKCVP---KDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFK 310
+ QP+ C + C + + K F C+ +D S +P C++ +F
Sbjct: 3460 YRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMP-MCSSTQFL 3518
Query: 311 C-NDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVR 369
C N+ KCIP W+CD ++DC+DG DEL P R C L ++ C+D C LC+ +
Sbjct: 3519 CANNEKCIPIWWKCDGQKDCSDGSDELALCPQ--RFCRLGQFQCSDGNCTSPQTLCNAHQ 3576
Query: 370 DCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEE---- 425
+C +G DE + CE + C E +N + C+ CD DC DE+
Sbjct: 3577 NCPDGSDE--DRLLCE--NHHCDSNEWQCAN--KRCIPESWQCDTFNDCEDNSDEDSSHC 3630
Query: 426 ----------RC------PLKRKCSAEEKC-----EKL--CITT---YDGHAACACPMGF 459
RC P KC + C E + C+++ D +C +
Sbjct: 3631 ASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNY 3690
Query: 460 LLAEDKYSCRDIDECMYEQDPV-CSQTCSNTVGSFRC 495
C +D+C D C + + VG FRC
Sbjct: 3691 RCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRC 3727
Score = 68.5 bits (160), Expect = 2e-10
Identities = 37/114 (32%), Positives = 54/114 (47%), Gaps = 7/114 (6%)
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCE 381
+C +E + + +C ++ C +TC++ RC+ + W CD DC +G DEM E
Sbjct: 2676 QCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGRCISEEWKCDNDNDCGDGSDEM--E 2733
Query: 382 VSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSA 435
C +TC P +N CV + CD DC G DE C L R C+A
Sbjct: 2734 SVCA--LHTCSPTAFTCANG--RCVQYSYRCDYYNDCGDGSDEAGC-LFRDCNA 2782
Score = 67.3 bits (157), Expect = 5e-10
Identities = 44/180 (24%), Positives = 86/180 (47%), Gaps = 8/180 (4%)
Query: 796 IDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPA 855
+ +D+ + +A+DW I+W+DV+ I A L+G ++ ++ ++L PA
Sbjct: 4131 VQEVDLKLKYVMQPDGIAVDW--VGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPA 4188
Query: 856 GLAFDWITDKIYWTDGGTN-RIEVSKSDGSMRTLLAWDHIDKPRDIVVN-PEGGVMYWSD 913
+A + ++WTD G +IE + +G R +L ++ + P + ++ +YWSD
Sbjct: 4189 AIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSD 4248
Query: 914 WGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGR 973
+ IE DG +R+ + M N +LD+ +++YW + N G G+
Sbjct: 4249 F-KEDVIETIKYDGTDRRVIAKEAM---NPYSLDIFEDQLYWISKEKGEVWKQNKFGQGK 4304
Score = 66.9 bits (156), Expect = 6e-10
Identities = 40/157 (25%), Positives = 82/157 (52%), Gaps = 6/157 (3%)
Query: 559 VFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTR-RVEVATL 617
++WS+ + I VA+++ + +I L+ PA +AV+ L+FWTD G ++E A +
Sbjct: 4156 IYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWM 4215
Query: 618 DGSKRAVLVANDLDKPRAIAV-HPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFW 676
+G R +LV DL P +++ + + ++W+D+ IE DG R+ + + +
Sbjct: 4216 NGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDF-KEDVIETIKYDGTDRRVIAKEAM-- 4272
Query: 677 PNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVT 713
N ++D E ++YW + + + G+ +++ T
Sbjct: 4273 -NPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKT 4308
Score = 65.7 bits (153), Expect = 1e-09
Identities = 64/247 (25%), Positives = 87/247 (35%), Gaps = 24/247 (9%)
Query: 111 DDAGC-ITPCLKINFSCQISCTCIPMEK--RXXXXXXXXXXXXXXXXXRSCDEHENRTIC 167
D+ GC + C + F CQ CIP +C H+ I
Sbjct: 58 DEIGCAVVTCQQGYFKCQSEGQCIPSSWVCDQDQDCDDGSDERQDCSQSTCSSHQ---IT 114
Query: 168 HSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIG---DVITNPTVLI 224
S CI E+ CD DC D +DE +C L A N D +
Sbjct: 115 CSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSS 174
Query: 225 ALTKPTVVIRYESF------CAKKAL----DNAANPRSTWNQPVELMRCAEIDFECKNTK 274
T + + F C +A DN S C F C + +
Sbjct: 175 DEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSD-EHACNYPTCGGYQFTCPSGR 233
Query: 275 CVPKDFQCDGDNDCGDWTDEDSCPMVP---GSCNAGEFKC-NDGKCIPERWRCDNERDCA 330
C+ +++ CDG++DC D DED C P C+ E+ C G+CI CD DC
Sbjct: 234 CIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCP 293
Query: 331 DGGDELN 337
DE N
Sbjct: 294 GREDENN 300
Score = 64.5 bits (150), Expect = 3e-09
Identities = 44/154 (28%), Positives = 66/154 (42%), Gaps = 26/154 (16%)
Query: 340 PNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV-SCEEDQYTCRPQEHLM 398
P S + C + C C+ W CDG +DC++ DE+ C V +C++ + C+ +
Sbjct: 22 PASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQ-- 79
Query: 399 SNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE-KCEK-LCI-TTYDGHAACAC 455
C+ VCD +DC G DE + + CS+ + C CI + Y C
Sbjct: 80 ------CIPSSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDC 133
Query: 456 PMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSN 488
P G D ++C Y P C Q TC N
Sbjct: 134 PDG----------ADENDCQY---PTCEQLTCDN 154
Score = 46.8 bits (106), Expect = 7e-04
Identities = 59/234 (25%), Positives = 82/234 (35%), Gaps = 31/234 (13%)
Query: 91 KAIDVIHTDPDDGPLNEGTEDDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXX 150
+ ID+ D +G+ D+ GC+ C F C CI + R
Sbjct: 1160 RCIDLSFVCDGDKDCVDGS-DEVGCVLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSD 1218
Query: 151 XXXXXRSCDE--HENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSAN 208
H + C +CI W CDG DC SDE N V KT PS+
Sbjct: 1219 EAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKT---CPSSY 1275
Query: 209 ASLNIGDVITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQ-PVELMRCAEID 267
+ G+ I + C + DN S P + RC
Sbjct: 1276 FHCDNGNCIHRAWL----------------CDR---DNDCGDMSDEKDCPTQPFRCPSWQ 1316
Query: 268 FEC-KNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPG-SCNAGEFKCNDGKCIPE 319
++C + CV CDG DC + TDE P+ G SC+ C +C+ E
Sbjct: 1317 WQCLGHNICVNLSVVCDGIFDCPNGTDES--PLCNGNSCSDFNGGCTH-ECVQE 1367
Score = 46.0 bits (104), Expect = 0.001
Identities = 32/99 (32%), Positives = 40/99 (40%), Gaps = 9/99 (9%)
Query: 99 DPDDGPLNEGTEDDAGCIT-PCLKINFSCQISCTCIPM----EKRXXXXXXXXXXXXXXX 153
D D+ + E+ C T C F C S CIP ++
Sbjct: 2843 DGDNDCGDNSDENPTYCTTHTCSSSEFQCA-SGRCIPQHWYCDQETDCFDASDEPASCGH 2901
Query: 154 XXRSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDE 192
R+C E + C CI EW+CDGDNDCGD SDE
Sbjct: 2902 SERTCLADEFK--CDGGR-CIPSEWICDGDNDCGDMSDE 2937
Score = 43.2 bits (97), Expect = 0.009
Identities = 19/42 (45%), Positives = 24/42 (57%), Gaps = 3/42 (7%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDV 197
R C E E R + CI W+CD NDCGD SDE +C++
Sbjct: 3757 RECTESEFRCV---NQQCIPSRWICDHYNDCGDNSDERDCEM 3795
Score = 39.5 bits (88), Expect = 0.11
Identities = 15/22 (68%), Positives = 17/22 (77%)
Query: 171 NVCIALEWLCDGDNDCGDFSDE 192
+VCI W CDGD+DCGD SDE
Sbjct: 3852 HVCIPPYWKCDGDDDCGDGSDE 3873
Score = 37.5 bits (83), Expect = 0.43
Identities = 29/110 (26%), Positives = 46/110 (41%), Gaps = 6/110 (5%)
Query: 86 RPSLQKAIDVIHTDPDDGPLNEGTEDDAGCIT-PCLKINFSCQISCTCIPMEKRXXXXXX 144
RP ++ I D +G +++ C C + F+C CIP R
Sbjct: 2959 RPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGL-CIPKIFRCDRHND 3017
Query: 145 XXXXXXXXX-XXRSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEI 193
++C + N+ C + CI+ ++CD DNDCGD SDE+
Sbjct: 3018 CGDYSDERGCLYQTCQQ--NQFTCQNGR-CISKTFVCDEDNDCGDGSDEL 3064
Score = 37.1 bits (82), Expect = 0.57
Identities = 18/40 (45%), Positives = 23/40 (57%), Gaps = 3/40 (7%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINC 195
R+C E+E C +CI + CD NDCGD+SDE C
Sbjct: 2991 RTCSENE--FTC-GYGLCIPKIFRCDRHNDCGDYSDERGC 3027
Score = 36.3 bits (80), Expect = 1.00
Identities = 16/41 (39%), Positives = 27/41 (65%), Gaps = 3/41 (7%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCD 196
+ C E+E + C + + CI + +CD +DCGD+SDE+ C+
Sbjct: 3926 KPCTEYEYK--CGNGH-CIPHDNVCDDADDCGDWSDELGCN 3963
>AY265358-1|AAP88586.1| 4655|Homo sapiens glycoprotein receptor
gp330/megalin precursor protein.
Length = 4655
Score = 603 bits (1490), Expect = e-171
Identities = 473/1634 (28%), Positives = 743/1634 (45%), Gaps = 156/1634 (9%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
CI L ++CDGD DC D SDE+ C + T+ A+ IG +TN +
Sbjct: 1161 CIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIG--VTNRCDGV-------- 1210
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTK-CVPKDFQCDGDNDCGDW 291
F D A P +P + C +F+C+ C+P ++CDG DC
Sbjct: 1211 -----FDCSDNSDEAGCP----TRPPGM--CHSDEFQCQEDGICIPNFWECDGHPDCLYG 1259
Query: 292 TDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEY 351
+DE + VP +C + F C++G CI W CD + DC D DE +C R C ++
Sbjct: 1260 SDEHNA-CVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFR-CPSWQW 1317
Query: 352 TCADRR-CVLKTWLCDGVRDCTNGEDEMN-CEV-SCEEDQYTCRPQEHLMSNAFRNCVNR 408
C CV + +CDG+ DC NG DE C SC + C + CV
Sbjct: 1318 QCLGHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHE----------CVQE 1367
Query: 409 KHVCDGMKDCPRG----DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAED 464
+ CP G +D + C +C C + C G C+C G++L D
Sbjct: 1368 PFGAKCL--CPLGFLLANDSKTCEDIDECDILGSCSQHCYNMR-GSFRCSCDTGYMLESD 1424
Query: 465 KYSCR-DIDECMY----EQDPVCSQTCSNTVGSFRCGCMTG-YILRPDERSCK------- 511
+C+ E + Q+ + + + ++ V + G YI+ D S
Sbjct: 1425 GRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSD 1484
Query: 512 PTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLVFWSENNLRVIRV 571
T F N R V+ D+ S++ L +A+D+ + ++W++ L I V
Sbjct: 1485 ATQGKTWSAFQNGTDRRVVF---DS--SII--LTETIAIDW--VGRNLYWTDYALETIEV 1535
Query: 572 AQMNTKNMSDVIRWGLETPAGVAVD--WIHDLLFWTDSGTR-RVEVATLDGSKRAVLVAN 628
++++ + + +I L P G+A+D LLFW+D G R+E A++DGS R V+V +
Sbjct: 1536 SKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQD 1595
Query: 629 DLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESK 688
+ P + + + L+++ D ++ D +G R+ VI ++ + + E
Sbjct: 1596 KIFWPCGLTIDYPNRLLYFMD-SYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDS 1654
Query: 689 IYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTG 748
+YW D + RA + V + P + + + + S +
Sbjct: 1655 VYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFSRCSHLCL 1714
Query: 749 MGIQTVH-------AGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDM 801
+ Q H +G ++ D+ +C + L+ R+ + L + + S D
Sbjct: 1715 LSSQGPHFYSCVCPSGWSLSPDL--LNCLRDDQPFLITVRQHIIFGISLNPE--VKSNDA 1770
Query: 802 VIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPA-GLAFD 860
++P+ I++ + +++D I+W + I+R +G+++T +++ P+ LA D
Sbjct: 1771 MVPIAGIQNGLDVEFDDAEQYIYWVE-NPGEIHRVKTDGTNRTVFASISMVGPSMNLALD 1829
Query: 861 WITDKIYWTDGGTNRIEVSKSDGSMR---TLLAWDH----IDKPRDIVVNPEGGVMYWSD 913
WI+ +Y T+ T IEV G +R TL+A D + P I V+P G +YWSD
Sbjct: 1830 WISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSD 1889
Query: 914 WGAS---PC-IERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLD 969
G P I A+MDG + K L G + + LD+ ++YW G IE N+D
Sbjct: 1890 QGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVD 1949
Query: 970 GTGRTKLIENLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTL------------ 1017
GT R L+ L HP+G+ ++ +++TD + I+ +K TGA + L
Sbjct: 1950 GTDRMILVHQLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGLQV 2009
Query: 1018 -----------GCGKNNGGCSHLCLLKPGGR-SCACPIGIKLNKDGKTCADGPINYLIFA 1065
GC N C +CL PGG SCAC G KLN D ++C+ P N I
Sbjct: 2010 YHRRNAAESSNGCSNNMNACQQICLPVPGGLFSCACATGFKLNPDNRSCS--PYNSFIVV 2067
Query: 1066 HRVD-IRVISLDVPYLIDVVLPLPPL-KNALGVDVDHSTGLIYWTD-----TGQRKIQRA 1118
+ IR SL++ + ++P+ +NAL VDVD S+G IYW D I+R
Sbjct: 2068 SMLSAIRGFSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASDNAIRRI 2127
Query: 1119 TRLGTHVETVIGNGL--HTADGIVIDSTGRKIYWTDG--GRNSIEVAELDGRNRKVLVWT 1174
G+ + ++ +G+ + GI +D +Y+T+ IEV ++ R+VL+
Sbjct: 2128 KPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKV 2187
Query: 1175 GLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGR 1234
+D PR I + + Y+FW+D+G KIER+ +D NR V+V I P GLA+DR +G
Sbjct: 2188 TVDMPRHIVVDPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGY 2247
Query: 1235 LYWNDAKILTIESSDFDGHDRRTVL--SNVPYPYGIVIVGQHIYWTDWKTKALHRADKT- 1291
+YW D + I +G + + S P PYGI + I W D K + +A K
Sbjct: 2248 VYWVDDSLDIIARIRINGENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKKIFQASKEP 2307
Query: 1292 -NASDPIVIRKNLEGLMDIRAIQSE-------RVLENACGTDNGGCSHLCLRSPLGYTCA 1343
N P VIR N+ L D+ + V N C +NGGCSHLC P +T
Sbjct: 2308 ENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFALPGLHTPK 2367
Query: 1344 CPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTI- 1402
C T K C E FLIFA S+ + L+ PE V+ T+
Sbjct: 2368 CDCAF----GTLQSDGKNCAISTENFLIFALSNSLRSLHLD-PENHSPPFQTINVERTVM 2422
Query: 1403 AVDYHWDLKMIFYTDLDLNVIRSINMTNMSE---SKTIISQKLETPNGLGVDWIANNIYW 1459
++DY I++T + + I+ +S + T+I+ + T +G+ DWI IY+
Sbjct: 2423 SLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRIYY 2482
Query: 1460 TDNEHKVIEVARLDGSSRKVLITGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQ 1519
+D +++I DGS+R V I + +PRA+ L P +GYLYW+DW H IER+ L G+
Sbjct: 2483 SDYLNQMINSMAEDGSNRTV-IARVPKPRAIVLDPCQGYLYWADWDTHAKIERATLGGNF 2541
Query: 1520 RQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQLVPDAKNPFGMTQF 1579
R IV L P+GLT+DY+E LYW DA RI+ S L G R +V A + FG+T +
Sbjct: 2542 RVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAVHAFGLTLY 2601
Query: 1580 KDYIYWTDWYKKSIIRADKRTGKNITLIRTN-LEMAMEIK-AVSADRQHGWNPCKESNGG 1637
YIYWTD Y + I RA+K G + TN L I V +Q NPC++ NGG
Sbjct: 2602 GQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNNPCEQFNGG 2661
Query: 1638 CSHLCLFRGHEYICACPDDPDHVECSTVKMLRNYRDTELKDEEFSNSTGHISFHNPNYSC 1697
CSH+C + C CP + + + K F+ S G + + C
Sbjct: 2662 CSHICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGRCI--SEEWKC 2719
Query: 1698 ATGGPGGNGPDHIE 1711
G+G D +E
Sbjct: 2720 DNDNDCGDGSDEME 2733
Score = 387 bits (953), Expect = e-106
Identities = 279/874 (31%), Positives = 393/874 (44%), Gaps = 67/874 (7%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
CI+ W+CD DNDCGD SDE NC+ +T P+ +
Sbjct: 1121 CISKNWVCDTDNDCGDGSDEKNCNSTET-----------------CQPSQFNCPNHRCID 1163
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWT 292
+ + K +D + N +CA D KC+ +CDG DC D +
Sbjct: 1164 LSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGD------KCIGVTNRCDGVFDCSDNS 1217
Query: 293 DEDSCP-MVPGSCNAGEFKC-NDGKCIPERWRCDNERDCADGGDELN-CKPNSIRNCSLD 349
DE CP PG C++ EF+C DG CIP W CD DC G DE N C P + C
Sbjct: 1218 DEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVP---KTCPSS 1274
Query: 350 EYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRK 409
+ C + C+ + WLCD DC + DE +C + C P CVN
Sbjct: 1275 YFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPT----QPFRC-PSWQWQCLGHNICVNLS 1329
Query: 410 HVCDGMKDCPRGDDEERCPLKRKCS-AEEKCEKLCITTYDGHAACACPMGFLLAEDKYSC 468
VCDG+ DCP G DE CS C C+ G A C CP+GFLLA D +C
Sbjct: 1330 VVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHECVQEPFG-AKCLCPLGFLLANDSKTC 1388
Query: 469 RDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLF---SNRI 525
DIDEC + CSQ C N GSFRC C TGY+L D R+CK T LL N+I
Sbjct: 1389 EDIDEC--DILGSCSQHCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKI 1446
Query: 526 GIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRW 585
V N S+V+ VA+D+ +FWS+ A N + V
Sbjct: 1447 IADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDS 1506
Query: 586 GLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHP--GDA 643
+ +A+DW+ L+WTD +EV+ +DGS R VL++ +L PR +A+ P +
Sbjct: 1507 SIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEH 1566
Query: 644 LVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAA 703
L+FW+DWG +P+IERA MDG R ++ D+IFWP GLTIDY +Y+ D+ ++
Sbjct: 1567 LLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCD 1626
Query: 704 FDGRDRRKVTTKGL--PHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVP 761
++G RR+V L HP+ALTLF+D++YWTD T+ + NK G V + P
Sbjct: 1627 YNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWP 1686
Query: 762 MDIHSRSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSN 821
+ I + + P + A + L L S+ P V P S L+ + +
Sbjct: 1687 LGIVAVHPSKQPNSVNPCAFSRCSHLCLLSSQGP-HFYSCVCPSGWSLSPDLLNC-LRDD 1744
Query: 822 SIFWTDVEKDTINRAYLN---GSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEV 878
F V + I LN S+ + + + + FD IYW + I
Sbjct: 1745 QPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVE-NPGEIHR 1803
Query: 879 SKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGG--NRKKLIFG 936
K+DG+ RT+ A + P + +S + IE + G RK LI
Sbjct: 1804 VKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIAN 1863
Query: 937 QMT-----WPNGLALDLVHNRIYWTDGGNKT-----IEYANLDGTG-RTKLIENLPH--P 983
T +P G+ +D ++YW+D G + I AN+DGT +T NL H
Sbjct: 1864 DGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLEC 1923
Query: 984 FGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTL 1017
LD+ +++W I+ N D G R L
Sbjct: 1924 VTLDIEEQKLYWAVTGRGVIERGNVD-GTDRMIL 1956
Score = 371 bits (913), Expect = e-101
Identities = 189/519 (36%), Positives = 275/519 (52%), Gaps = 27/519 (5%)
Query: 263 CAEIDFECKNTK-----CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCI 317
C++ +F C N + C+P+ + CDGD DC D DE+ +C+ EF C G CI
Sbjct: 2948 CSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQ-NCTRRTCSENEFTCGYGLCI 3006
Query: 318 PERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDE 377
P+ +RCD DC D DE C + C +++TC + RC+ KT++CD DC +G DE
Sbjct: 3007 PKIFRCDRHNDCGDYSDERGCL---YQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDE 3063
Query: 378 MNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCS--A 435
+ C + TC P E N C+ +C+ + DC DE+ C + +C +
Sbjct: 3064 LMH--LCHTPEPTCPPHEFKCDNG--RCIEMMKLCNHLDDCLDNSDEKGCGIN-ECHDPS 3118
Query: 436 EEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRC 495
C+ C T C+C G+ L DK +C DIDEC E VCSQ C N +GS+ C
Sbjct: 3119 ISGCDHNCTDTLTSFY-CSCRPGYKLMSDKRTCVDIDECT-EMPFVCSQKCENVIGSYIC 3176
Query: 496 GCMTGYILRPDERSCKPTGE-SPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHY 554
C GY+ PD ++C+ P L+FSNR +R + + G Y +++GL N VALD+
Sbjct: 3177 KCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDR 3236
Query: 555 EKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEV 614
+K ++W + +VI +N N +I L +AVDW+ L+W D+ + V
Sbjct: 3237 VEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFV 3296
Query: 615 ATLDGSKRAVLV-----AND---LDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKR 666
+ L+G R +L AN+ D PR +A+HP ++W DWG I R MDG +
Sbjct: 3297 SDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNK 3356
Query: 667 KTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLF 726
+I ++ WPNG+TIDYT +YWADA IE + +G R V LPHPFA+T+F
Sbjct: 3357 SVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIF 3416
Query: 727 DDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIH 765
+D IYWTDW+T+++ NK G QT+ + P DIH
Sbjct: 3417 EDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIH 3455
Score = 341 bits (839), Expect = 1e-92
Identities = 201/655 (30%), Positives = 338/655 (51%), Gaps = 33/655 (5%)
Query: 1024 GGCSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGPINY--LIFAHRVDIRVISLDVPYL 1080
G C C +PG C C G L + G+ C A+ +IF++ D+ + +
Sbjct: 356 GICDQKCESRPGRHLCHCEEGYILER-GQYCKANDSFGEASIIFSNGRDLLIGDIH-GRS 413
Query: 1081 IDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIV 1140
+++ A+GV + ++WTDT Q K+ G +++ V+ + T + +
Sbjct: 414 FRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLA 473
Query: 1141 IDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSA 1200
+D KIY + N I++ LDG R L+ L PR IA+ GY+F+SDW + +
Sbjct: 474 VDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLS 533
Query: 1201 ---KIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRT 1257
K+ERA MDG+NR+ +V K+ WP G+ +D I R+YW D++ IE+ +DG R+T
Sbjct: 534 GEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKT 593
Query: 1258 VL---SNVPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQS 1314
V+ S +P+P+G+ + +++TDW A+ +A+K ++P V + + S
Sbjct: 594 VVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHS 653
Query: 1315 ER--VLENACGTDNGGCSHLCLRSP------LGYTCACPTGMPFEKSTTDQTPKKCKSHP 1366
R N C +NGGC +C+ S LG+ C C G + TD+ + C +
Sbjct: 654 LRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLD---TDE--RHCIA-V 707
Query: 1367 EEFLIFATRGSITYISLESPEQWDVTLPVKEVKNT-IAVDYHWDLKMIFYTDLDLNVIRS 1425
+ FLIF+++ +I I Q DV +PV + + +D+ IF++D+ ++I
Sbjct: 708 QNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFK 767
Query: 1426 INMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITGLT 1485
+ + + + ++E L DWI+ N+YWTD+ +K I V RL +R+ ++ L
Sbjct: 768 QKIDGTGR-EILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVVQYLN 826
Query: 1486 EPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYW 1545
PR++ + P GYL+++DW I R++ DGS ++ LG+PNGL ID+ RLYW
Sbjct: 827 NPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYW 886
Query: 1546 TDALKDRIDTSDLNGQHRVQL--VPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKN 1603
DA D+I+ S +G R +L + +PFG+ F +++++TDW +IIR K G
Sbjct: 887 VDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGE 946
Query: 1604 ITLIRTNLEMAMEIKAVSADRQHGWNPCKE---SNGGCSHLCL-FRGHEYICACP 1654
+T+IR+ + + +K+ + Q G N C + NG CSH C + +C CP
Sbjct: 947 MTVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCP 1001
Score = 334 bits (820), Expect = 2e-90
Identities = 195/618 (31%), Positives = 314/618 (50%), Gaps = 49/618 (7%)
Query: 774 EKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTI 833
E ++++ +DL + + + S +++ + AV + + +FWTD ++ +
Sbjct: 393 EASIIFSNGRDLLIGDIHGR----SFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKV 448
Query: 834 NRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDH 893
+NG + +++ ++ P LA DW+ +KIY + NRI++ DGS R L ++
Sbjct: 449 FSVDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITEN 508
Query: 894 IDKPRDIVVNPEGGVMYWSDW---GASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVH 950
+ PR I V+P G +++SDW P +ERA MDG NRK L+ ++ WP G+ LD++
Sbjct: 509 LGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMIS 568
Query: 951 NRIYWTDGGNKTIEYANLDGTGRTKLIEN---LPHPFGLDLYGDEVFWTDWDTQSIQAAN 1007
R+YW D IE DG R ++ +PHPFG+ L+ +VF+TDW ++ AN
Sbjct: 569 KRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKAN 628
Query: 1008 KDTG--------AKRRTLG---------------CGKNNGGCSHLCLLKPG------GRS 1038
K T A R G C NNGGC +C+L G
Sbjct: 629 KFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFR 688
Query: 1039 CACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKN-ALGVD 1097
C C G +L+ D + C N+LIF+ +V IR I + DV++P+ + +G+D
Sbjct: 689 CKCTFGFQLDTDERHCI-AVQNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGID 747
Query: 1098 VDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNS 1157
D I+++D + I + GT E + N + + + D + +YWTD S
Sbjct: 748 FDAQDSTIFFSDMSKHMIFKQKIDGTGREILAANRVENVESLAFDWISKNLYWTDSHYKS 807
Query: 1158 IEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVD 1217
I V L + R+ +V L++PR++ +H GY+F++DW AKI RA DG++ +++
Sbjct: 808 ISVMRLADKTRRTVV-QYLNNPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVIN 866
Query: 1218 NKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTV--LSNVPYPYGIVIVGQHI 1275
+ WPNGLAID RLYW DA IE S FDG DRR + + + +P+G+ I G+H+
Sbjct: 867 TTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHL 926
Query: 1276 YWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQ-SERVLENACGT---DNGGCSH 1331
++TDW+ A+ R K + + VIR + ++ +++ + + NAC NG CSH
Sbjct: 927 FFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSH 986
Query: 1332 LCLRSP-LGYTCACPTGM 1348
C P C CP GM
Sbjct: 987 FCFPVPNFQRVCGCPYGM 1004
Score = 313 bits (768), Expect = 4e-84
Identities = 164/493 (33%), Positives = 259/493 (52%), Gaps = 28/493 (5%)
Query: 270 CKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDC 329
C N C +CD DC D +DE +C + C EF C +G+CIP + CD++ DC
Sbjct: 152 CDNGACYNTSQKCDWKVDCRDSSDEINCTEI---CLHNEFSCGNGECIPRAYVCDHDNDC 208
Query: 330 ADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQY 389
DG DE C + C ++TC RC+ + W+CDG DC + DE CE S D +
Sbjct: 209 QDGSDEHAC---NYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCE-SGPHDVH 264
Query: 390 TCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCS----AEEKCEKLCIT 445
C P+E + R C++ VCDG+ DCP +DE + CS + C+ C
Sbjct: 265 KCSPREWSCPESGR-CISIYKVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQYQCHE 323
Query: 446 TYDGHAACACPMGFLLAE-DKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILR 504
T G AC CP G+++ D +C + D+C +C Q C + G C C GYIL
Sbjct: 324 TPYG-GACFCPPGYIINHNDSRTCVEFDDCQIWG--ICDQKCESRPGRHLCHCEEGYILE 380
Query: 505 PDERSCKPT---GESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALD--YHYEKKLV 559
+ CK GE+ +++FSN + + G ++ +V+ + VA+ +HY + V
Sbjct: 381 RGQY-CKANDSFGEA-SIIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYHLQRV 438
Query: 560 FWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDG 619
FW++ + +N N+ +V+ +ETP +AVDW+++ ++ ++ R+++ LDG
Sbjct: 439 FWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDG 498
Query: 620 SKRAVLVANDLDKPRAIAVHPGDALVFWTDW---GPNPKIERADMDGDKRKTVIYDEIFW 676
S R L+ +L PR IAV P +F++DW PK+ERA MDG RK ++ ++ W
Sbjct: 499 SYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGW 558
Query: 677 PNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKG--LPHPFALTLFDDAIYWTD 734
P G+T+D ++YW D++ IE +DG R+ V G +PHPF ++LF+ +++TD
Sbjct: 559 PAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTD 618
Query: 735 WHTKSISTVNKNT 747
W ++ NK T
Sbjct: 619 WTKMAVLKANKFT 631
Score = 312 bits (767), Expect = 6e-84
Identities = 177/513 (34%), Positives = 263/513 (51%), Gaps = 33/513 (6%)
Query: 259 ELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCP-MVPGS--CNAGEFKCNDGK 315
E+ C F+C + CV + +CDG DC D +DE CP P C A F+C +
Sbjct: 3794 EMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKNHV 3853
Query: 316 CIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGE 375
CIP W+CD + DC DG DE + S + + C + RC+ +C+GV DC +G
Sbjct: 3854 CIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDGT 3913
Query: 376 DEMNCEVSCEE-DQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPL-KRKC 433
DE E C + C E+ N +C+ +VCD DC DE C K +
Sbjct: 3914 DE--TEEHCRKPTPKPCTEYEYKCGNG--HCIPHDNVCDDADDCGDWSDELGCNKGKERT 3969
Query: 434 SAEEKCEKLCITTYDGHAACACPMGF-LLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGS 492
AE CE+ C +G C+C GF D+ SC DI+EC EQ C Q C NT GS
Sbjct: 3970 CAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINEC--EQFGTCPQHCRNTKGS 4027
Query: 493 FRCGCMTGYILRPDE--RSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVAL 550
+ C C G+ D + C G SP LL + + IR+ L+ + + ++ A+
Sbjct: 4028 YECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQDEEYIQAV 4087
Query: 551 DYHYEKK-----LVFWS----ENNLRVIRVA-----QMNTKNMSDVIRWGLE---TPAGV 593
DY ++ + +V+++ + I+ A + N+ + L+ P G+
Sbjct: 4088 DYDWDPEDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGI 4147
Query: 594 AVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPN 653
AVDW+ ++W+D +R+EVA LDG R L++ DLD+P AIAV+P L+FWTDWG
Sbjct: 4148 AVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKE 4207
Query: 654 PKIERADMDGDKRKTVIYDEIFWPNGLTIDY-TESKIYWADAKHHVIERAAFDGRDRRKV 712
PK+E A M+G+ R ++++++ WP GL+IDY +IYW+D K VIE +DG DRR V
Sbjct: 4208 PKLESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRR-V 4266
Query: 713 TTKGLPHPFALTLFDDAIYWTDWHTKSISTVNK 745
K +P++L +F+D +YW + NK
Sbjct: 4267 IAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNK 4299
Score = 291 bits (713), Expect = 2e-77
Identities = 258/974 (26%), Positives = 414/974 (42%), Gaps = 108/974 (11%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEI-NCDVVK-TSLLVPSANASLNIGDVITNPTVLI 224
C S CI W+CD D DC D SDE +C +S + +N + +
Sbjct: 74 CQSEGQCIPSSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDC 133
Query: 225 ALTKPTVVIRYESFCAKKALDNAA----NPRSTWN----QPVELMRCAEI----DFECKN 272
+Y + C + DN A + + W + + C EI +F C N
Sbjct: 134 PDGADENDCQYPT-CEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGN 192
Query: 273 TKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADG 332
+C+P+ + CD DNDC D +DE +C +C +F C G+CI + W CD E DC D
Sbjct: 193 GECIPRAYVCDHDNDCQDGSDEHACNYP--TCGGYQFTCPSGRCIYQNWVCDGEDDCKDN 250
Query: 333 GDELNCK--PNSIRNCSLDEYTCADR-RCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQY 389
GDE C+ P+ + CS E++C + RC+ +CDG+ DC EDE N
Sbjct: 251 GDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMT 310
Query: 390 TCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRG-----DDEERCPLKRKCSAEEKCEKLCI 444
C N C + G CP G +D C C C++ C
Sbjct: 311 LCSAL-----NCQYQCHETPY--GGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKC- 362
Query: 445 TTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILR 504
+ G C C G++L +Y C+ D E + S +G G ++
Sbjct: 363 ESRPGRHLCHCEEGYILERGQY-CKANDS-FGEASIIFSNGRDLLIGDIH-GRSFRILVE 419
Query: 505 PDERSCKPTGESPTLLFSNRIGIRQVWL--TGDNYMSV-VKGLHNAVALDYHYEKK---L 558
R G + + F + R W + SV + GL+ L+ E
Sbjct: 420 SQNR-----GVAVGVAFHYHLQ-RVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLA 473
Query: 559 VFWSENNLRVI--RVAQMNTKNMSDVIRWGLET-----PAGVAVDWIHDLLFWTD----S 607
V W N + ++ +V +++ N+ R L T P G+AVD LF++D S
Sbjct: 474 VDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLS 533
Query: 608 GTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRK 667
G ++E A +DGS R LV L P + + V+W D IE DG +RK
Sbjct: 534 GEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVD-SRFDYIETVTYDGIQRK 592
Query: 668 TVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFD 727
TV++ P+ + E ++++ D + +A +V + P+ +T++
Sbjct: 593 TVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYH 652
Query: 728 DAI--YWTDWHTKS---------ISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKL 776
Y T+ + +S N G+G + +D R C +
Sbjct: 653 SLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFRC-KCTFGFQLDTDERHCIAV-QNF 710
Query: 777 LLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSA-VALDWDQKSNSIFWTDVEKDTINR 835
L+++ + +R D+++PV S V +D+D + ++IF++D+ K I +
Sbjct: 711 LIFSSQVAIRGIPFTLST---QEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFK 767
Query: 836 AYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSK-SDGSMRTLLAWDHI 894
++G+ + + + + LAFDWI+ +YWTD I V + +D + RT++ ++
Sbjct: 768 QKIDGTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV--QYL 825
Query: 895 DKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIY 954
+ PR +VV+P G ++++DW I RA DG + +I + WPNGLA+D +R+Y
Sbjct: 826 NNPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLY 885
Query: 955 WTDGGNKTIEYANLDGTGRTKL--IENLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGA 1012
W D IE++ DG R +L IE + HPFGL ++G+ +F+TDW +I K G
Sbjct: 886 WVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGG 945
Query: 1013 KRRTLGCG-------------------------KNNGGCSHLCLLKPG-GRSCACPIGIK 1046
+ + G NG CSH C P R C CP G++
Sbjct: 946 EMTVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMR 1005
Query: 1047 LNKDGKTCADGPIN 1060
L + TC P N
Sbjct: 1006 LASNHLTCEGDPTN 1019
Score = 242 bits (593), Expect = 7e-63
Identities = 126/335 (37%), Positives = 183/335 (54%), Gaps = 18/335 (5%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPI--NYLIFAHRVDIRVISLDVPYLIDV 1083
CS C G C C G DGKTC YLIF++R +R +++D Y +
Sbjct: 3163 CSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTID-GYFYSL 3221
Query: 1084 VLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDS 1143
+L L N + +D D +YW DT ++ I+R T+ ET+I + L A+ + +D
Sbjct: 3222 ILE--GLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDW 3279
Query: 1144 TGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDS--------PRAIALHYEYGYMFWSD 1195
RK+YW D + + V++L+G +R++L +D+ PR +ALH +YGY++W+D
Sbjct: 3280 VSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWAD 3339
Query: 1196 WGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDR 1255
WG A I R MDG N+ VI+ K++WPNG+ ID LYW DA + IE SD +GH R
Sbjct: 3340 WGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHR 3399
Query: 1256 RTVLSN-VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQS 1314
TV +P+P+ I I IYWTDW T+ + + +K + S+ + DI
Sbjct: 3400 HTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHP 3459
Query: 1315 ER--VLENACGTDNGGCSHLCLRSP--LGYTCACP 1345
R ++ N CGT+NGGCSHLCL P G+TC CP
Sbjct: 3460 YRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECP 3494
Score = 205 bits (501), Expect = 1e-51
Identities = 115/341 (33%), Positives = 177/341 (51%), Gaps = 20/341 (5%)
Query: 1329 CSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQ 1388
CS C Y C C G + + +T ++ S+ E +LIF+ R + ++++
Sbjct: 3163 CSQKCENVIGSYICKCAPG--YLREPDGKTCRQ-NSNIEPYLIFSNRYYLRNLTIDG--- 3216
Query: 1389 WDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGL 1448
+ +L ++ + N +A+D+ K +++ D VI + + N + +TII+ +L L
Sbjct: 3217 YFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFL-NKTNKETIINHRLPAAESL 3275
Query: 1449 GVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITGLTE---------PRALALFPAKGYL 1499
VDW++ +YW D + V+ L+G R++L + PR LAL P GYL
Sbjct: 3276 AVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYL 3335
Query: 1500 YWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLN 1559
YW+DWG YI R +DG+ + +I+ L +PNG+TIDY LYW DA I+ SDL
Sbjct: 3336 YWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLE 3395
Query: 1560 GQHRVQLVPDA-KNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIK 1618
G HR + A +PF +T F+D IYWTDW +++ + +K G N + +I
Sbjct: 3396 GHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIH 3455
Query: 1619 AVSADRQH-GWNPCKESNGGCSHLCLFR--GHEYICACPDD 1656
RQ NPC +NGGCSHLCL + G + C CPDD
Sbjct: 3456 VYHPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPDD 3496
Score = 200 bits (488), Expect = 4e-50
Identities = 98/281 (34%), Positives = 157/281 (55%), Gaps = 34/281 (12%)
Query: 796 IDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPA 855
ID + +E + + VALD+D+ ++W D ++ I R +LN +++ TI++ L
Sbjct: 3214 IDGYFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAE 3273
Query: 856 GLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHID--------KPRDIVVNPEGG 907
LA DW++ K+YW D + + VS +G R +LA +D PR + ++P+ G
Sbjct: 3274 SLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYG 3333
Query: 908 VMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYAN 967
+YW+DWG I R MDG N+ +I ++ WPNG+ +D ++ +YW D IEY++
Sbjct: 3334 YLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSD 3393
Query: 968 LDGTGRTKLIEN-LPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTL--------- 1017
L+G R + + LPHPF + ++ D ++WTDW+T++++ NK G+ R+TL
Sbjct: 3394 LEGHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFD 3453
Query: 1018 --------------GCGKNNGGCSHLCLLKPGGR--SCACP 1042
CG NNGGCSHLCL+KPGG+ +C CP
Sbjct: 3454 IHVYHPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECP 3494
Score = 182 bits (444), Expect = 8e-45
Identities = 117/361 (32%), Positives = 181/361 (50%), Gaps = 30/361 (8%)
Query: 1327 GGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEE-FLIFATRGSITYISLES 1385
G C C + Y C C G S +D+ K+C + L+ I +L S
Sbjct: 4015 GTCPQHCRNTKGSYECVCADGFT---SMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSS 4071
Query: 1386 PEQWDVTLPVKEVKNTIAVDYHWD-----LKMIFYT----DLDLNVIRSINMTNMSESKT 1436
E++ L +E AVDY WD L +++YT I+ + N +
Sbjct: 4072 -ERFSEYLQDEEYIQ--AVDYDWDPEDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRN 4128
Query: 1437 IISQKLET-------PNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLI-TGLTEPR 1488
+ Q+++ P+G+ VDW+ +IYW+D ++K IEVA+LDG RK LI T L +P
Sbjct: 4129 NLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPA 4188
Query: 1489 ALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDY-KERRLYWTD 1547
A+A+ P G ++W+DWG+ P +E ++++G R I+V DLG+P GL+IDY R+YW+D
Sbjct: 4189 AIAVNPKLGLMFWTDWGKEPKLESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSD 4248
Query: 1548 ALKDRIDTSDLNGQHRVQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADK--RTGKNIT 1605
+D I+T +G R + +A NP+ + F+D +YW K + + +K + K T
Sbjct: 4249 FKEDVIETIKYDGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKT 4308
Query: 1606 LIRTNLEMAMEIKAVSADRQHGWNPCKESNGGCSHLCLFRGHEYICACPDDPDHVECSTV 1665
L+ + I + N CK+ CSHLCL R Y CACP +E ST
Sbjct: 4309 LVVNPWLTQVRIFHQLRYNKSVPNLCKQI---CSHLCLLRPGGYSCACPQGSSFIEGSTT 4365
Query: 1666 K 1666
+
Sbjct: 4366 E 4366
Score = 180 bits (439), Expect = 3e-44
Identities = 143/504 (28%), Positives = 223/504 (44%), Gaps = 54/504 (10%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPG-SCNAGEFKC-----NDGKC 316
C +F+C +C+P ++ CDGDNDCGD +DED +C+ EF C D +C
Sbjct: 2906 CLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRC 2965
Query: 317 IPERWRCDNERDCADGGDE-LNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGE 375
IP+ W CD + DC DG DE NC + R CS +E+TC C+ K + CD DC +
Sbjct: 2966 IPQSWVCDGDVDCTDGYDENQNC---TRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYS 3022
Query: 376 DEMNC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE--ERCPL-KR 431
DE C +C+++Q+TC+ N C+++ VCD DC G DE C +
Sbjct: 3023 DERGCLYQTCQQNQFTCQ-------NG--RCISKTFVCDEDNDCGDGSDELMHLCHTPEP 3073
Query: 432 KCSAEE-KCEK-LCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNT 489
C E KC+ CI + C L D+ C I+EC C C++T
Sbjct: 3074 TCPPHEFKCDNGRCI---EMMKLCNHLDDCLDNSDEKGC-GINECHDPSISGCDHNCTDT 3129
Query: 490 VGSFRCGCMTGYILRPDERSCKPTGESPTLLF------SNRIGIRQVWLTGDNYMSVVKG 543
+ SF C C GY L D+R+C E + F N IG + Y+ G
Sbjct: 3130 LTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIG-SYICKCAPGYLREPDG 3188
Query: 544 LHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLF 603
+ + E L+F + LR + + +I GL+ + D + L+
Sbjct: 3189 --KTCRQNSNIEPYLIFSNRYYLRNLTI----DGYFYSLILEGLDNVVALDFDRVEKRLY 3242
Query: 604 WTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDG 663
W D+ + +E L+ + + ++ + L ++AV ++W D + +D++G
Sbjct: 3243 WIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLD-ARLDGLFVSDLNG 3301
Query: 664 DKRK-----TVIYDEIFW---PNGLTIDYTESKIYWADAKHHV-IERAAFDGRDRRKVTT 714
R+ V + F P GL + +YWAD H I R DG ++ + +
Sbjct: 3302 GHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIIS 3361
Query: 715 KGLPHPFALTL--FDDAIYWTDWH 736
L P +T+ +D +YW D H
Sbjct: 3362 TKLEWPNGITIDYTNDLLYWADAH 3385
Score = 172 bits (418), Expect = 1e-41
Identities = 120/357 (33%), Positives = 171/357 (47%), Gaps = 29/357 (8%)
Query: 1024 GGCSHLCLLKPGGRSCACPIGIKLNKD--GKTCA-DGPINYLIFAHRVDIRVISLDVPYL 1080
G C C G C C G D GK CA +G L+ V IR +L
Sbjct: 4015 GTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERF 4074
Query: 1081 IDVVLPLPPLKNALGVDVD-HSTGL--IYWTDTGQRK----IQRA---------TRLGTH 1124
+ + ++ A+ D D GL +Y+T G+ I+RA L
Sbjct: 4075 SEYLQDEEYIQ-AVDYDWDPEDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQE 4133
Query: 1125 VETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIAL 1184
V+ + + DGI +D GR IYW+D IEVA+LDGR RK L+ T LD P AIA+
Sbjct: 4134 VDLKLKYVMQP-DGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAV 4192
Query: 1185 HYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEG-RLYWNDAKIL 1243
+ + G MFW+DWG K+E A M+G +R ++V + WP GL+ID + R+YW+D K
Sbjct: 4193 NPKLGLMFWTDWGKEPKLESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKED 4252
Query: 1244 TIESSDFDGHDRRTVLSNVPYPYGIVIVGQHIYWTDWKTKALHRADK---TNASDPIVIR 1300
IE+ +DG DRR + PY + I +YW + + + +K +V+
Sbjct: 4253 VIETIKYDGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVN 4312
Query: 1301 KNLEGLMDIRAIQSERVLENACGTDNGGCSHLCLRSPLGYTCACPTGMPF-EKSTTD 1356
L + ++ + + N C CSHLCL P GY+CACP G F E STT+
Sbjct: 4313 PWLTQVRIFHQLRYNKSVPNLC---KQICSHLCLLRPGGYSCACPQGSSFIEGSTTE 4366
Score = 167 bits (407), Expect = 2e-40
Identities = 161/628 (25%), Positives = 263/628 (41%), Gaps = 73/628 (11%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
+ CD R C S + CI +W CDG DC D +DEI C VV + G
Sbjct: 26 QECDSAHFR--CGSGH-CIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSE---GQ 79
Query: 216 VITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKC 275
I + + V + C D+ ++ R +Q C+ C N +C
Sbjct: 80 CIPS----------SWVCDQDQDC-----DDGSDERQDCSQST----CSSHQITCSNGQC 120
Query: 276 VPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDE 335
+P +++CD DC D DE+ C P +C + C++G C +CD + DC D DE
Sbjct: 121 IPSEYRCDHVRDCPDGADENDC-QYP-TCE--QLTCDNGACYNTSQKCDWKVDCRDSSDE 176
Query: 336 LNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV-SCEEDQYTCRPQ 394
+NC + N E++C + C+ + ++CD DC +G DE C +C Q+TC P
Sbjct: 177 INCTEICLHN----EFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTC-PS 231
Query: 395 EHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPL----KRKCSAEE-KCEK--LCITTY 447
C+ + VCDG DC DE+ C KCS E C + CI+ Y
Sbjct: 232 --------GRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIY 283
Query: 448 DGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV--CSQTCSNTVGSFRCGCMTGYIL-R 504
C + ED+ + C C C T C C GYI+
Sbjct: 284 ---KVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYIINH 340
Query: 505 PDERSCKPTGESP-----TLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLV 559
D R+C + +R G R + + Y+ + +G + A D E ++
Sbjct: 341 NDSRTCVEFDDCQIWGICDQKCESRPG-RHLCHCEEGYI-LERGQY-CKANDSFGEASII 397
Query: 560 FWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDG 619
F + +L + + + + + + G+ GVA + +FWTD+ +V ++G
Sbjct: 398 FSNGRDLLIGDIHGRSFRILVESQNRGV--AVGVAFHYHLQRVFWTDTVQNKVFSVDING 455
Query: 620 SKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNG 679
++ ++ P +AV + ++ + N +I+ ++DG R T+I + + P G
Sbjct: 456 LNIQEVLNVSVETPENLAVDWVNNKIYLVETKVN-RIDMVNLDGSYRVTLITENLGHPRG 514
Query: 680 LTIDYTESKIYWAD----AKHHVIERAAFDGRDRRK-VTTK-GLPHPFALTLFDDAIYWT 733
+ +D T ++++D + +ERA DG +R+ V TK G P L + +YW
Sbjct: 515 IAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWV 574
Query: 734 DWHTKSISTVNKNTGMGIQTVHAGLNVP 761
D I TV + VH G +P
Sbjct: 575 DSRFDYIETVTYDGIQRKTVVHGGSLIP 602
Score = 167 bits (407), Expect = 2e-40
Identities = 82/227 (36%), Positives = 116/227 (51%), Gaps = 20/227 (8%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
+C F CKN +CVP + CDG +DC D +DE C + +C++ F C G+CIP W
Sbjct: 1025 QCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHW 1084
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCE 381
RCD DC DG DE NC ++ +C +YTC + +C+ K W+CD DC +G DE NC
Sbjct: 1085 RCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCN 1144
Query: 382 VSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPL-----KRKCSAE 436
S E TC+P + N C++ VCDG KDC G DE C L + KC++
Sbjct: 1145 -STE----TCQPSQFNCPN--HRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASG 1197
Query: 437 EKC---EKLCITTYD-----GHAACACPMGFLLAEDKYSCRDIDECM 475
+KC C +D A C + D++ C++ C+
Sbjct: 1198 DKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICI 1244
Score = 159 bits (387), Expect = 6e-38
Identities = 86/228 (37%), Positives = 121/228 (53%), Gaps = 22/228 (9%)
Query: 854 PAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSD 913
P G+A DW+ IYW+D RIEV+K DG R L +D+P I VNP+ G+M+W+D
Sbjct: 4144 PDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTD 4203
Query: 914 WGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHN-RIYWTDGGNKTIEYANLDGTG 972
WG P +E A M+G +R L+F + WP GL++D ++N RIYW+D IE DGT
Sbjct: 4204 WGKEPKLESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTD 4263
Query: 973 RTKLIENLPHPFGLDLYGDEVFWTDWDTQSIQAANK-DTGAKRRTLGCG----------- 1020
R + + +P+ LD++ D+++W + + NK G K +TL
Sbjct: 4264 RRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFHQ 4323
Query: 1021 -KNNGG--------CSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPI 1059
+ N CSHLCLL+PGG SCACP G + T D I
Sbjct: 4324 LRYNKSVPNLCKQICSHLCLLRPGGYSCACPQGSSFIEGSTTECDAAI 4371
Score = 152 bits (368), Expect = 1e-35
Identities = 137/518 (26%), Positives = 215/518 (41%), Gaps = 56/518 (10%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C E +F C N +C+P + CD NDCGD +DE C M +C+ F+C G C+ +
Sbjct: 3759 CTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEM--RTCHPEYFQCTSGHCVHSELK 3816
Query: 323 CDNERDCADGGDELNCKPNSIRN---CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMN 379
CD DC D DE +C P + C + C + C+ W CDG DC +G DE
Sbjct: 3817 CDGSADCLDASDEADC-PTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDE-- 3873
Query: 380 CEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDD--EERC--PLKRKCSA 435
E+ D P N C+ VC+G+ DC G D EE C P + C+
Sbjct: 3874 -ELHLCLDVPCNSPNRFRCDN--NRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTE 3930
Query: 436 -EEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSN-TVGSF 493
E KC +D A G D+ C E ++ +C Q C+ G F
Sbjct: 3931 YEYKCGNGHCIPHDNVCDDADDCGDW--SDELGCNKGKERTCAEN-ICEQNCTQLNEGGF 3987
Query: 494 RCGCMTGYILRPDERS-------CKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHN 546
C C G+ +R+ C+ G P + + V G MS G
Sbjct: 3988 ICSCTAGFETNVFDRTSCLDINECEQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRC 4047
Query: 547 AVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHD-----L 601
A + +N+R IR ++++ S+ ++ E V DW + +
Sbjct: 4048 AAE-----GSSPLLLLPDNVR-IRKYNLSSERFSEYLQ-DEEYIQAVDYDWDPEDIGLSV 4100
Query: 602 LFWTDSG-------TRRVEVATLDGSKRAVLVANDLD-----KPRAIAVHPGDALVFWTD 649
+++T G +R + + + ++ DL +P IAV ++W+D
Sbjct: 4101 VYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSD 4160
Query: 650 WGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWAD-AKHHVIERAAFDGRD 708
N +IE A +DG RK +I ++ P + ++ ++W D K +E A +G D
Sbjct: 4161 -VKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKLESAWMNGED 4219
Query: 709 RRKVTTKGLPHPFALT---LFDDAIYWTDWHTKSISTV 743
R + + L P L+ L +D IYW+D+ I T+
Sbjct: 4220 RNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETI 4257
Score = 150 bits (364), Expect = 4e-35
Identities = 89/269 (33%), Positives = 122/269 (45%), Gaps = 28/269 (10%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
C+ + CD NDCGD SDE C L NA+ +
Sbjct: 2753 CVQYSYRCDYYNDCGDGSDEAGC-------LFRDCNATTEF------------MCNNRRC 2793
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTK-CVPKDFQCDGDNDCGDW 291
I E C +DN + ++ + C +C N+ C+P+ + CDGDNDCGD
Sbjct: 2794 IPREFIC--NGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDN 2851
Query: 292 TDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEY 351
+DE+ +C++ EF+C G+CIP+ W CD E DC D DE +S R C DE+
Sbjct: 2852 SDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEF 2911
Query: 352 TCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSN---AFRNCVNR 408
C RC+ W+CDG DC + DE + C+ C E L N R C+ +
Sbjct: 2912 KCDGGRCIPSEWICDGDNDCGDMSDE-DKRHQCQNQ--NCSDSEFLCVNDRPPDRRCIPQ 2968
Query: 409 KHVCDGMKDCPRGDDEERCPLKRKCSAEE 437
VCDG DC G DE + +R CS E
Sbjct: 2969 SWVCDGDVDCTDGYDENQNCTRRTCSENE 2997
Score = 147 bits (357), Expect = 3e-34
Identities = 87/254 (34%), Positives = 120/254 (47%), Gaps = 27/254 (10%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
CI W CD DNDCGD SDE + +S ++ D N T T +
Sbjct: 3647 CIPQAWKCDVDNDCGDHSDEP----------IEECMSSAHLCD---NFTEFSCKTNYRCI 3693
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEI-DFECKNTKCVPKDFQCDGDNDCGDW 291
++ + C +D+ + ++ Q E C + DF CKN C+P +QCDG NDCGD
Sbjct: 3694 PKW-AVC--NGVDDCRD--NSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDN 3748
Query: 292 TDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEY 351
+DE++C P C EF+C + +CIP RW CD+ DC D DE +C+ +R C + +
Sbjct: 3749 SDEENC--APRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCE---MRTCHPEYF 3803
Query: 352 TCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHV 411
C CV CDG DC + DE +C + Y C+ N C+
Sbjct: 3804 QCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGAY-CQATMFECKN--HVCIPPYWK 3860
Query: 412 CDGMKDCPRGDDEE 425
CDG DC G DEE
Sbjct: 3861 CDGDDDCGDGSDEE 3874
Score = 147 bits (355), Expect = 5e-34
Identities = 116/474 (24%), Positives = 212/474 (44%), Gaps = 34/474 (7%)
Query: 255 NQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDG 314
NQ C+E +F C C+PK F+CD NDCGD++DE C + +C +F C +G
Sbjct: 2985 NQNCTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGC--LYQTCQQNQFTCQNG 3042
Query: 315 KCIPERWRCDNERDCADGGDEL-NCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTN 373
+CI + + CD + DC DG DEL + C E+ C + RC+ LC+ + DC +
Sbjct: 3043 RCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLD 3102
Query: 374 GEDEMNCEVS-CEEDQYT-CRPQ-EHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLK 430
DE C ++ C + + C +++ + +C + + C D +E +
Sbjct: 3103 NSDEKGCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCV--DIDECTEMP 3160
Query: 431 RKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCR---DIDECMYEQDPVCSQTCS 487
CS +KCE + G C C G+L D +CR +I+ + + +
Sbjct: 3161 FVCS--QKCENVI-----GSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNL- 3212
Query: 488 NTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVK-GLHN 546
T+ + + + + + + R I +++L N +++ L
Sbjct: 3213 -TIDGYFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPA 3271
Query: 547 AVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIR--------WGLETPAGVAVDWI 598
A +L + + ++W + L + V+ +N + + + + + P G+A+
Sbjct: 3272 AESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQ 3331
Query: 599 HDLLFWTDSGTRR-VEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIE 657
+ L+W D G R + +DG+ ++V+++ L+ P I + + L++W D IE
Sbjct: 3332 YGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWAD-AHLGYIE 3390
Query: 658 RADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERA-AFDGRDRR 710
+D++G R TV YD P+ I E IYW D +E+ +DG +R+
Sbjct: 3391 YSDLEGHHRHTV-YDGAL-PHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQ 3442
Score = 136 bits (329), Expect = 7e-31
Identities = 64/186 (34%), Positives = 98/186 (52%), Gaps = 11/186 (5%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C +++C N +C+P+ +QCD NDC D +DEDS +C G+F+C +G+CIP+ W+
Sbjct: 3594 CDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWK 3653
Query: 323 CDNERDCADGGDE--LNCKPNSIRNCSLDEYTC-ADRRCVLKTWLCDGVRDCTNGEDEMN 379
CD + DC D DE C ++ + E++C + RC+ K +C+GV DC + DE
Sbjct: 3654 CDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQG 3713
Query: 380 CEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKC 439
CE + TC P +C+ + CDG DC DEE C + +E +C
Sbjct: 3714 CE------ERTCHPVGDFRCKN-HHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRC 3766
Query: 440 -EKLCI 444
+ CI
Sbjct: 3767 VNQQCI 3772
Score = 131 bits (317), Expect = 2e-29
Identities = 101/334 (30%), Positives = 144/334 (43%), Gaps = 46/334 (13%)
Query: 169 STNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTK 228
S CI+ EW CD DNDCGD SDE+ V P+A N G + +
Sbjct: 2708 SNGRCISEEWKCDNDNDCGDGSDEME-SVCALHTCSPTAFTCAN-GRCV----------Q 2755
Query: 229 PTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDC 288
+ Y + C + D A N E M C N +C+P++F C+G ++C
Sbjct: 2756 YSYRCDYYNDCGDGS-DEAGCLFRDCNATTEFM--------CNNRRCIPREFICNGVDNC 2806
Query: 289 GD--WTDEDSCPMVPGSCNAGEFKC-NDGKCIPERWRCDNERDCADGGDELNCKPNSIRN 345
D +DE +CP +C +G KC N CIP + CD + DC D DE N +
Sbjct: 2807 HDNNTSDEKNCP--DRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDE-NPTYCTTHT 2863
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNC 405
CS E+ CA RC+ + W CD DC + DE SC + TC E C
Sbjct: 2864 CSSSEFQCASGRCIPQHWYCDQETDCFDASDE---PASCGHSERTCLADEFKCDGG--RC 2918
Query: 406 VNRKHVCDGMKDCPRGDDEERCPLKRKCSAE--EKCEKLCITTYDGHAACACPMGFLLAE 463
+ + +CDG DC DE++ + +C + E LC+ C P ++
Sbjct: 2919 IPSEWICDGDNDCGDMSDEDK---RHQCQNQNCSDSEFLCVNDRPPDRRC-IPQSWVCDG 2974
Query: 464 DKYSCRDIDECMYEQDPVCS-QTCSNTVGSFRCG 496
D C D Y+++ C+ +TCS F CG
Sbjct: 2975 D-VDCTD----GYDENQNCTRRTCSE--NEFTCG 3001
Score = 128 bits (308), Expect = 2e-28
Identities = 66/174 (37%), Positives = 90/174 (51%), Gaps = 19/174 (10%)
Query: 257 PVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKC-NDGK 315
P C F C + C+P D++CDG DC D DE C +V +C G FKC ++G+
Sbjct: 22 PASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVV--TCQQGYFKCQSEGQ 79
Query: 316 CIPERWRCDNERDCADGGDE-LNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNG 374
CIP W CD ++DC DG DE +C ++ CS + TC++ +C+ + CD VRDC +G
Sbjct: 80 CIPSSWVCDQDQDCDDGSDERQDCSQST---CSSHQITCSNGQCIPSEYRCDHVRDCPDG 136
Query: 375 EDEMNCEV-SCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC 427
DE +C+ +CE Q TC N C N CD DC DE C
Sbjct: 137 ADENDCQYPTCE--QLTC-------DNG--ACYNTSQKCDWKVDCRDSSDEINC 179
Score = 126 bits (303), Expect = 1e-27
Identities = 64/184 (34%), Positives = 95/184 (51%), Gaps = 17/184 (9%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
RC F C N +C+ ++++CD DNDCGD +DE +C+ F C +G+C+ +
Sbjct: 2699 RCGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSY 2758
Query: 322 RCDNERDCADGGDELNCKPNSIRNC-SLDEYTCADRRCVLKTWLCDGVRDC--TNGEDEM 378
RCD DC DG DE C R+C + E+ C +RRC+ + ++C+GV +C N DE
Sbjct: 2759 RCDYYNDCGDGSDEAGC---LFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEK 2815
Query: 379 NC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEE--RCPLKRKCSA 435
NC + +C+ C SN C+ R ++CDG DC DE C S+
Sbjct: 2816 NCPDRTCQSGYTKCH-----NSNI---CIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSS 2867
Query: 436 EEKC 439
E +C
Sbjct: 2868 EFQC 2871
Score = 108 bits (259), Expect = 2e-22
Identities = 52/171 (30%), Positives = 79/171 (46%), Gaps = 4/171 (2%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C F+C + C C+ +C D +DED C++ E++C + +CIPE W+
Sbjct: 3553 CRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQ 3612
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV 382
CD DC D DE + + R C ++ CA+ RC+ + W CD DC + DE E
Sbjct: 3613 CDTFNDCEDNSDE-DSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEE- 3670
Query: 383 SCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKC 433
C + C C+ + VC+G+ DC DE+ C +R C
Sbjct: 3671 -CMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCE-ERTC 3719
Score = 103 bits (247), Expect = 6e-21
Identities = 86/301 (28%), Positives = 119/301 (39%), Gaps = 47/301 (15%)
Query: 166 ICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIA 225
+C + CI + W CDG DC D SDE+ + L + G+ + T+ A
Sbjct: 3518 LCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRL---GQFQCSDGNCTSPQTLCNA 3574
Query: 226 LTK-PTVVIRYESFCAKKALDN----AANPR---STWNQPVELMRCAEIDFE----CKNT 273
P C D+ AN R +W Q C + E C +
Sbjct: 3575 HQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESW-QCDTFNDCEDNSDEDSSHCASR 3633
Query: 274 KCVPKDFQC------------DGDNDCGDWTDE--DSCPMVPGSC-NAGEFKCNDG-KCI 317
C P F+C D DNDCGD +DE + C C N EF C +CI
Sbjct: 3634 TCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCI 3693
Query: 318 PERWRCDNERDCADGGDELNCKPNSIRNC-SLDEYTCADRRCVLKTWLCDGVRDCTNGED 376
P+ C+ DC D DE C+ R C + ++ C + C+ W CDG DC + D
Sbjct: 3694 PKWAVCNGVDDCRDNSDEQGCEE---RTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSD 3750
Query: 377 EMNCEV-SCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSA 435
E NC C E ++ C Q+ C+ + +CD DC DE C + R C
Sbjct: 3751 EENCAPRECTESEFRCVNQQ---------CIPSRWICDHYNDCGDNSDERDCEM-RTCHP 3800
Query: 436 E 436
E
Sbjct: 3801 E 3801
Score = 90.2 bits (214), Expect = 6e-17
Identities = 73/277 (26%), Positives = 113/277 (40%), Gaps = 44/277 (15%)
Query: 254 WNQPVELMRCAEIDFECKNTKCVP---KDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFK 310
+ QP+ C + C + + K F C+ +D S +P C++ +F
Sbjct: 3460 YRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMP-MCSSTQFL 3518
Query: 311 C-NDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVR 369
C N+ KCIP W+CD ++DC+DG DEL P R C L ++ C+D C LC+ +
Sbjct: 3519 CANNEKCIPIWWKCDGQKDCSDGSDELALCPQ--RFCRLGQFQCSDGNCTSPQTLCNAHQ 3576
Query: 370 DCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEE---- 425
+C +G DE + CE + C E +N + C+ CD DC DE+
Sbjct: 3577 NCPDGSDE--DRLLCE--NHHCDSNEWQCAN--KRCIPESWQCDTFNDCEDNSDEDSSHC 3630
Query: 426 ----------RC------PLKRKCSAEEKC-----EKL--CITT---YDGHAACACPMGF 459
RC P KC + C E + C+++ D +C +
Sbjct: 3631 ASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNY 3690
Query: 460 LLAEDKYSCRDIDECMYEQDPV-CSQTCSNTVGSFRC 495
C +D+C D C + + VG FRC
Sbjct: 3691 RCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRC 3727
Score = 68.5 bits (160), Expect = 2e-10
Identities = 37/114 (32%), Positives = 54/114 (47%), Gaps = 7/114 (6%)
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCE 381
+C +E + + +C ++ C +TC++ RC+ + W CD DC +G DEM E
Sbjct: 2676 QCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGRCISEEWKCDNDNDCGDGSDEM--E 2733
Query: 382 VSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSA 435
C +TC P +N CV + CD DC G DE C L R C+A
Sbjct: 2734 SVCA--LHTCSPTAFTCANG--RCVQYSYRCDYYNDCGDGSDEAGC-LFRDCNA 2782
Score = 66.5 bits (155), Expect = 8e-10
Identities = 43/180 (23%), Positives = 86/180 (47%), Gaps = 8/180 (4%)
Query: 796 IDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPA 855
+ +D+ + +A+DW I+W+DV+ I A L+G ++ ++ ++L PA
Sbjct: 4131 VQEVDLKLKYVMQPDGIAVDW--VGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPA 4188
Query: 856 GLAFDWITDKIYWTDGGTN-RIEVSKSDGSMRTLLAWDHIDKPRDIVVN-PEGGVMYWSD 913
+A + ++WTD G ++E + +G R +L ++ + P + ++ +YWSD
Sbjct: 4189 AIAVNPKLGLMFWTDWGKEPKLESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSD 4248
Query: 914 WGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGR 973
+ IE DG +R+ + M N +LD+ +++YW + N G G+
Sbjct: 4249 F-KEDVIETIKYDGTDRRVIAKEAM---NPYSLDIFEDQLYWISKEKGEVWKQNKFGQGK 4304
Score = 66.1 bits (154), Expect = 1e-09
Identities = 40/157 (25%), Positives = 82/157 (52%), Gaps = 6/157 (3%)
Query: 559 VFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTR-RVEVATL 617
++WS+ + I VA+++ + +I L+ PA +AV+ L+FWTD G ++E A +
Sbjct: 4156 IYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKLESAWM 4215
Query: 618 DGSKRAVLVANDLDKPRAIAV-HPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFW 676
+G R +LV DL P +++ + + ++W+D+ IE DG R+ + + +
Sbjct: 4216 NGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDF-KEDVIETIKYDGTDRRVIAKEAM-- 4272
Query: 677 PNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVT 713
N ++D E ++YW + + + G+ +++ T
Sbjct: 4273 -NPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKT 4308
Score = 65.7 bits (153), Expect = 1e-09
Identities = 64/247 (25%), Positives = 87/247 (35%), Gaps = 24/247 (9%)
Query: 111 DDAGC-ITPCLKINFSCQISCTCIPMEK--RXXXXXXXXXXXXXXXXXRSCDEHENRTIC 167
D+ GC + C + F CQ CIP +C H+ I
Sbjct: 58 DEIGCAVVTCQQGYFKCQSEGQCIPSSWVCDQDQDCDDGSDERQDCSQSTCSSHQ---IT 114
Query: 168 HSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIG---DVITNPTVLI 224
S CI E+ CD DC D +DE +C L A N D +
Sbjct: 115 CSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSS 174
Query: 225 ALTKPTVVIRYESF------CAKKAL----DNAANPRSTWNQPVELMRCAEIDFECKNTK 274
T + + F C +A DN S C F C + +
Sbjct: 175 DEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSD-EHACNYPTCGGYQFTCPSGR 233
Query: 275 CVPKDFQCDGDNDCGDWTDEDSCPMVP---GSCNAGEFKC-NDGKCIPERWRCDNERDCA 330
C+ +++ CDG++DC D DED C P C+ E+ C G+CI CD DC
Sbjct: 234 CIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCP 293
Query: 331 DGGDELN 337
DE N
Sbjct: 294 GREDENN 300
Score = 64.5 bits (150), Expect = 3e-09
Identities = 44/154 (28%), Positives = 66/154 (42%), Gaps = 26/154 (16%)
Query: 340 PNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV-SCEEDQYTCRPQEHLM 398
P S + C + C C+ W CDG +DC++ DE+ C V +C++ + C+ +
Sbjct: 22 PASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQ-- 79
Query: 399 SNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE-KCEK-LCI-TTYDGHAACAC 455
C+ VCD +DC G DE + + CS+ + C CI + Y C
Sbjct: 80 ------CIPSSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDC 133
Query: 456 PMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSN 488
P G D ++C Y P C Q TC N
Sbjct: 134 PDG----------ADENDCQY---PTCEQLTCDN 154
Score = 46.8 bits (106), Expect = 7e-04
Identities = 59/234 (25%), Positives = 82/234 (35%), Gaps = 31/234 (13%)
Query: 91 KAIDVIHTDPDDGPLNEGTEDDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXX 150
+ ID+ D +G+ D+ GC+ C F C CI + R
Sbjct: 1160 RCIDLSFVCDGDKDCVDGS-DEVGCVLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSD 1218
Query: 151 XXXXXRSCDE--HENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSAN 208
H + C +CI W CDG DC SDE N V KT PS+
Sbjct: 1219 EAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKT---CPSSY 1275
Query: 209 ASLNIGDVITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQ-PVELMRCAEID 267
+ G+ I + C + DN S P + RC
Sbjct: 1276 FHCDNGNCIHRAWL----------------CDR---DNDCGDMSDEKDCPTQPFRCPSWQ 1316
Query: 268 FEC-KNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPG-SCNAGEFKCNDGKCIPE 319
++C + CV CDG DC + TDE P+ G SC+ C +C+ E
Sbjct: 1317 WQCLGHNICVNLSVVCDGIFDCPNGTDES--PLCNGNSCSDFNGGCTH-ECVQE 1367
Score = 46.0 bits (104), Expect = 0.001
Identities = 32/99 (32%), Positives = 40/99 (40%), Gaps = 9/99 (9%)
Query: 99 DPDDGPLNEGTEDDAGCIT-PCLKINFSCQISCTCIPM----EKRXXXXXXXXXXXXXXX 153
D D+ + E+ C T C F C S CIP ++
Sbjct: 2843 DGDNDCGDNSDENPTYCTTHTCSSSEFQCA-SGRCIPQHWYCDQETDCFDASDEPASCGH 2901
Query: 154 XXRSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDE 192
R+C E + C CI EW+CDGDNDCGD SDE
Sbjct: 2902 SERTCLADEFK--CDGGR-CIPSEWICDGDNDCGDMSDE 2937
Score = 43.2 bits (97), Expect = 0.009
Identities = 19/42 (45%), Positives = 24/42 (57%), Gaps = 3/42 (7%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDV 197
R C E E R + CI W+CD NDCGD SDE +C++
Sbjct: 3757 RECTESEFRCV---NQQCIPSRWICDHYNDCGDNSDERDCEM 3795
Score = 39.5 bits (88), Expect = 0.11
Identities = 15/22 (68%), Positives = 17/22 (77%)
Query: 171 NVCIALEWLCDGDNDCGDFSDE 192
+VCI W CDGD+DCGD SDE
Sbjct: 3852 HVCIPPYWKCDGDDDCGDGSDE 3873
Score = 37.5 bits (83), Expect = 0.43
Identities = 29/110 (26%), Positives = 46/110 (41%), Gaps = 6/110 (5%)
Query: 86 RPSLQKAIDVIHTDPDDGPLNEGTEDDAGCIT-PCLKINFSCQISCTCIPMEKRXXXXXX 144
RP ++ I D +G +++ C C + F+C CIP R
Sbjct: 2959 RPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGL-CIPKIFRCDRHND 3017
Query: 145 XXXXXXXXX-XXRSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEI 193
++C + N+ C + CI+ ++CD DNDCGD SDE+
Sbjct: 3018 CGDYSDERGCLYQTCQQ--NQFTCQNGR-CISKTFVCDEDNDCGDGSDEL 3064
Score = 37.1 bits (82), Expect = 0.57
Identities = 18/40 (45%), Positives = 23/40 (57%), Gaps = 3/40 (7%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINC 195
R+C E+E C +CI + CD NDCGD+SDE C
Sbjct: 2991 RTCSENE--FTC-GYGLCIPKIFRCDRHNDCGDYSDERGC 3027
Score = 36.3 bits (80), Expect = 1.00
Identities = 16/41 (39%), Positives = 27/41 (65%), Gaps = 3/41 (7%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCD 196
+ C E+E + C + + CI + +CD +DCGD+SDE+ C+
Sbjct: 3926 KPCTEYEYK--CGNGH-CIPHDNVCDDADDCGDWSDELGCN 3963
>AY265357-1|AAP88585.1| 4655|Homo sapiens glycoprotein receptor
gp330/megalin precursor protein.
Length = 4655
Score = 603 bits (1490), Expect = e-171
Identities = 473/1634 (28%), Positives = 743/1634 (45%), Gaps = 156/1634 (9%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
CI L ++CDGD DC D SDE+ C + T+ A+ IG +TN +
Sbjct: 1161 CIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIG--VTNRCDGV-------- 1210
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTK-CVPKDFQCDGDNDCGDW 291
F D A P +P + C +F+C+ C+P ++CDG DC
Sbjct: 1211 -----FDCSDNSDEAGCP----TRPPGM--CHSDEFQCQEDGICIPNFWECDGHPDCLYG 1259
Query: 292 TDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEY 351
+DE + VP +C + F C++G CI W CD + DC D DE +C R C ++
Sbjct: 1260 SDEHNA-CVPKTCPSSYFHCDNGNCIHRXWLCDRDNDCGDMSDEKDCPTQPFR-CPSWQW 1317
Query: 352 TCADRR-CVLKTWLCDGVRDCTNGEDEMN-CEV-SCEEDQYTCRPQEHLMSNAFRNCVNR 408
C CV + +CDG+ DC NG DE C SC + C + CV
Sbjct: 1318 QCLGHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHE----------CVQE 1367
Query: 409 KHVCDGMKDCPRG----DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAED 464
+ CP G +D + C +C C + C G C+C G++L D
Sbjct: 1368 PFGAKCL--CPLGFLLANDSKTCEDIDECDILGSCSQHCYNMR-GSFRCSCDTGYMLESD 1424
Query: 465 KYSCR-DIDECMY----EQDPVCSQTCSNTVGSFRCGCMTG-YILRPDERSCK------- 511
+C+ E + Q+ + + + ++ V + G YI+ D S
Sbjct: 1425 GRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSD 1484
Query: 512 PTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLVFWSENNLRVIRV 571
T F N R V+ D+ S++ L +A+D+ + ++W++ L I V
Sbjct: 1485 ATQGKTWSAFQNGTDRRVVF---DS--SII--LTETIAIDW--VGRNLYWTDYALETIEV 1535
Query: 572 AQMNTKNMSDVIRWGLETPAGVAVD--WIHDLLFWTDSGTR-RVEVATLDGSKRAVLVAN 628
++++ + + +I L P G+A+D LLFW+D G R+E A++DGS R V+V +
Sbjct: 1536 SKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQD 1595
Query: 629 DLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESK 688
+ P + + + L+++ D ++ D +G R+ VI ++ + + E
Sbjct: 1596 KIFWPCGLTIDYPNRLLYFMD-SYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDS 1654
Query: 689 IYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTG 748
+YW D + RA + V + P + + + + S +
Sbjct: 1655 VYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFSRCSHLCL 1714
Query: 749 MGIQTVH-------AGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDM 801
+ Q H +G ++ D+ +C + L+ R+ + L + + S D
Sbjct: 1715 LSSQGPHFYSCVCPSGWSLSPDL--LNCLRDDQPFLITVRQHIIFGISLNPE--VKSNDA 1770
Query: 802 VIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPA-GLAFD 860
++P+ I++ + +++D I+W + I+R +G+++T +++ P+ LA D
Sbjct: 1771 MVPIAGIQNGLDVEFDDAEQYIYWVE-NPGEIHRVKTDGTNRTVFASISMVGPSMNLALD 1829
Query: 861 WITDKIYWTDGGTNRIEVSKSDGSMR---TLLAWDH----IDKPRDIVVNPEGGVMYWSD 913
WI+ +Y T+ T IEV G +R TL+A D + P I V+P G +YWSD
Sbjct: 1830 WISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSD 1889
Query: 914 WGAS---PC-IERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLD 969
G P I A+MDG + K L G + + LD+ ++YW G IE N+D
Sbjct: 1890 QGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVD 1949
Query: 970 GTGRTKLIENLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTL------------ 1017
GT R L+ L HP+G+ ++ +++TD + I+ +K TGA + L
Sbjct: 1950 GTDRMILVHQLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGLQV 2009
Query: 1018 -----------GCGKNNGGCSHLCLLKPGGR-SCACPIGIKLNKDGKTCADGPINYLIFA 1065
GC N C +CL PGG SCAC G KLN D ++C+ P N I
Sbjct: 2010 YHRRNAAESSNGCSNNMNACQQICLPVPGGLFSCACATGFKLNPDNRSCS--PYNSFIVV 2067
Query: 1066 HRVD-IRVISLDVPYLIDVVLPLPPL-KNALGVDVDHSTGLIYWTD-----TGQRKIQRA 1118
+ IR SL++ + ++P+ +NAL VDVD S+G IYW D I+R
Sbjct: 2068 SMLSAIRGFSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASDNAIRRI 2127
Query: 1119 TRLGTHVETVIGNGL--HTADGIVIDSTGRKIYWTDG--GRNSIEVAELDGRNRKVLVWT 1174
G+ + ++ +G+ + GI +D +Y+T+ IEV ++ R+VL+
Sbjct: 2128 KPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKV 2187
Query: 1175 GLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGR 1234
+D PR I + + Y+FW+D+G KIER+ +D NR V+V I P GLA+DR +G
Sbjct: 2188 TVDMPRHIVVDPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGY 2247
Query: 1235 LYWNDAKILTIESSDFDGHDRRTVL--SNVPYPYGIVIVGQHIYWTDWKTKALHRADKT- 1291
+YW D + I +G + + S P PYGI + I W D K + +A K
Sbjct: 2248 VYWVDDSLDIIARIRINGENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKKIFQASKEP 2307
Query: 1292 -NASDPIVIRKNLEGLMDIRAIQSE-------RVLENACGTDNGGCSHLCLRSPLGYTCA 1343
N P VIR N+ L D+ + V N C +NGGCSHLC P +T
Sbjct: 2308 ENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFALPGLHTPK 2367
Query: 1344 CPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTI- 1402
C T K C E FLIFA S+ + L+ PE V+ T+
Sbjct: 2368 CDCAF----GTLQSDGKNCAISTENFLIFALSNSLRSLHLD-PENHSPPFQTINVERTVM 2422
Query: 1403 AVDYHWDLKMIFYTDLDLNVIRSINMTNMSE---SKTIISQKLETPNGLGVDWIANNIYW 1459
++DY I++T + + I+ +S + T+I+ + T +G+ DWI IY+
Sbjct: 2423 SLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRIYY 2482
Query: 1460 TDNEHKVIEVARLDGSSRKVLITGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQ 1519
+D +++I DGS+R V I + +PRA+ L P +GYLYW+DW H IER+ L G+
Sbjct: 2483 SDYLNQMINSMAEDGSNRTV-IARVPKPRAIVLDPCQGYLYWADWDTHAKIERATLGGNF 2541
Query: 1520 RQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQLVPDAKNPFGMTQF 1579
R IV L P+GLT+DY+E LYW DA RI+ S L G R +V A + FG+T +
Sbjct: 2542 RVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAVHAFGLTLY 2601
Query: 1580 KDYIYWTDWYKKSIIRADKRTGKNITLIRTN-LEMAMEIK-AVSADRQHGWNPCKESNGG 1637
YIYWTD Y + I RA+K G + TN L I V +Q NPC++ NGG
Sbjct: 2602 GQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNNPCEQFNGG 2661
Query: 1638 CSHLCLFRGHEYICACPDDPDHVECSTVKMLRNYRDTELKDEEFSNSTGHISFHNPNYSC 1697
CSH+C + C CP + + + K F+ S G + + C
Sbjct: 2662 CSHICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGRCI--SEEWKC 2719
Query: 1698 ATGGPGGNGPDHIE 1711
G+G D +E
Sbjct: 2720 DNDNDCGDGSDEME 2733
Score = 387 bits (953), Expect = e-106
Identities = 279/874 (31%), Positives = 393/874 (44%), Gaps = 67/874 (7%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
CI+ W+CD DNDCGD SDE NC+ +T P+ +
Sbjct: 1121 CISKNWVCDTDNDCGDGSDEKNCNSTET-----------------CQPSQFNCPNHRCID 1163
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWT 292
+ + K +D + N +CA D KC+ +CDG DC D +
Sbjct: 1164 LSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGD------KCIGVTNRCDGVFDCSDNS 1217
Query: 293 DEDSCP-MVPGSCNAGEFKC-NDGKCIPERWRCDNERDCADGGDELN-CKPNSIRNCSLD 349
DE CP PG C++ EF+C DG CIP W CD DC G DE N C P + C
Sbjct: 1218 DEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVP---KTCPSS 1274
Query: 350 EYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRK 409
+ C + C+ + WLCD DC + DE +C + C P CVN
Sbjct: 1275 YFHCDNGNCIHRXWLCDRDNDCGDMSDEKDCPT----QPFRC-PSWQWQCLGHNICVNLS 1329
Query: 410 HVCDGMKDCPRGDDEERCPLKRKCS-AEEKCEKLCITTYDGHAACACPMGFLLAEDKYSC 468
VCDG+ DCP G DE CS C C+ G A C CP+GFLLA D +C
Sbjct: 1330 VVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHECVQEPFG-AKCLCPLGFLLANDSKTC 1388
Query: 469 RDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLF---SNRI 525
DIDEC + CSQ C N GSFRC C TGY+L D R+CK T LL N+I
Sbjct: 1389 EDIDEC--DILGSCSQHCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKI 1446
Query: 526 GIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRW 585
V N S+V+ VA+D+ +FWS+ A N + V
Sbjct: 1447 IADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDS 1506
Query: 586 GLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHP--GDA 643
+ +A+DW+ L+WTD +EV+ +DGS R VL++ +L PR +A+ P +
Sbjct: 1507 SIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEH 1566
Query: 644 LVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAA 703
L+FW+DWG +P+IERA MDG R ++ D+IFWP GLTIDY +Y+ D+ ++
Sbjct: 1567 LLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCD 1626
Query: 704 FDGRDRRKVTTKGL--PHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVP 761
++G RR+V L HP+ALTLF+D++YWTD T+ + NK G V + P
Sbjct: 1627 YNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWP 1686
Query: 762 MDIHSRSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSN 821
+ I + + P + A + L L S+ P V P S L+ + +
Sbjct: 1687 LGIVAVHPSKQPNSVNPCAFSRCSHLCLLSSQGP-HFYSCVCPSGWSLSPDLLNC-LRDD 1744
Query: 822 SIFWTDVEKDTINRAYLN---GSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEV 878
F V + I LN S+ + + + + FD IYW + I
Sbjct: 1745 QPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVE-NPGEIHR 1803
Query: 879 SKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGG--NRKKLIFG 936
K+DG+ RT+ A + P + +S + IE + G RK LI
Sbjct: 1804 VKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIAN 1863
Query: 937 QMT-----WPNGLALDLVHNRIYWTDGGNKT-----IEYANLDGTG-RTKLIENLPH--P 983
T +P G+ +D ++YW+D G + I AN+DGT +T NL H
Sbjct: 1864 DGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLEC 1923
Query: 984 FGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTL 1017
LD+ +++W I+ N D G R L
Sbjct: 1924 VTLDIEEQKLYWAVTGRGVIERGNVD-GTDRMIL 1956
Score = 371 bits (913), Expect = e-101
Identities = 189/519 (36%), Positives = 275/519 (52%), Gaps = 27/519 (5%)
Query: 263 CAEIDFECKNTK-----CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCI 317
C++ +F C N + C+P+ + CDGD DC D DE+ +C+ EF C G CI
Sbjct: 2948 CSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQ-NCTRRTCSENEFTCGYGLCI 3006
Query: 318 PERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDE 377
P+ +RCD DC D DE C + C +++TC + RC+ KT++CD DC +G DE
Sbjct: 3007 PKIFRCDRHNDCGDYSDERGCL---YQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDE 3063
Query: 378 MNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCS--A 435
+ C + TC P E N C+ +C+ + DC DE+ C + +C +
Sbjct: 3064 LMH--LCHTPEPTCPPHEFKCDNG--RCIEMMKLCNHLDDCLDNSDEKGCGIN-ECHDPS 3118
Query: 436 EEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRC 495
C+ C T C+C G+ L DK +C DIDEC E VCSQ C N +GS+ C
Sbjct: 3119 ISGCDHNCTDTLTSFY-CSCRPGYKLMSDKRTCVDIDECT-EMPFVCSQKCENVIGSYIC 3176
Query: 496 GCMTGYILRPDERSCKPTGE-SPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHY 554
C GY+ PD ++C+ P L+FSNR +R + + G Y +++GL N VALD+
Sbjct: 3177 KCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDR 3236
Query: 555 EKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEV 614
+K ++W + +VI +N N +I L +AVDW+ L+W D+ + V
Sbjct: 3237 VEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFV 3296
Query: 615 ATLDGSKRAVLV-----AND---LDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKR 666
+ L+G R +L AN+ D PR +A+HP ++W DWG I R MDG +
Sbjct: 3297 SDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNK 3356
Query: 667 KTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLF 726
+I ++ WPNG+TIDYT +YWADA IE + +G R V LPHPFA+T+F
Sbjct: 3357 SVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIF 3416
Query: 727 DDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIH 765
+D IYWTDW+T+++ NK G QT+ + P DIH
Sbjct: 3417 EDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIH 3455
Score = 341 bits (839), Expect = 1e-92
Identities = 201/655 (30%), Positives = 338/655 (51%), Gaps = 33/655 (5%)
Query: 1024 GGCSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGPINY--LIFAHRVDIRVISLDVPYL 1080
G C C +PG C C G L + G+ C A+ +IF++ D+ + +
Sbjct: 356 GICDQKCESRPGRHLCHCEEGYILER-GQYCKANDSFGEASIIFSNGRDLLIGDIH-GRS 413
Query: 1081 IDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIV 1140
+++ A+GV + ++WTDT Q K+ G +++ V+ + T + +
Sbjct: 414 FRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLA 473
Query: 1141 IDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSA 1200
+D KIY + N I++ LDG R L+ L PR IA+ GY+F+SDW + +
Sbjct: 474 VDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLS 533
Query: 1201 ---KIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRT 1257
K+ERA MDG+NR+ +V K+ WP G+ +D I R+YW D++ IE+ +DG R+T
Sbjct: 534 GEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKT 593
Query: 1258 VL---SNVPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQS 1314
V+ S +P+P+G+ + +++TDW A+ +A+K ++P V + + S
Sbjct: 594 VVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHS 653
Query: 1315 ER--VLENACGTDNGGCSHLCLRSP------LGYTCACPTGMPFEKSTTDQTPKKCKSHP 1366
R N C +NGGC +C+ S LG+ C C G + TD+ + C +
Sbjct: 654 LRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLD---TDE--RHCIA-V 707
Query: 1367 EEFLIFATRGSITYISLESPEQWDVTLPVKEVKNT-IAVDYHWDLKMIFYTDLDLNVIRS 1425
+ FLIF+++ +I I Q DV +PV + + +D+ IF++D+ ++I
Sbjct: 708 QNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFK 767
Query: 1426 INMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITGLT 1485
+ + + + ++E L DWI+ N+YWTD+ +K I V RL +R+ ++ L
Sbjct: 768 QKIDGTGR-EILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVVQYLN 826
Query: 1486 EPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYW 1545
PR++ + P GYL+++DW I R++ DGS ++ LG+PNGL ID+ RLYW
Sbjct: 827 NPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYW 886
Query: 1546 TDALKDRIDTSDLNGQHRVQL--VPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKN 1603
DA D+I+ S +G R +L + +PFG+ F +++++TDW +IIR K G
Sbjct: 887 VDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGE 946
Query: 1604 ITLIRTNLEMAMEIKAVSADRQHGWNPCKE---SNGGCSHLCL-FRGHEYICACP 1654
+T+IR+ + + +K+ + Q G N C + NG CSH C + +C CP
Sbjct: 947 MTVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCP 1001
Score = 334 bits (820), Expect = 2e-90
Identities = 195/618 (31%), Positives = 314/618 (50%), Gaps = 49/618 (7%)
Query: 774 EKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTI 833
E ++++ +DL + + + S +++ + AV + + +FWTD ++ +
Sbjct: 393 EASIIFSNGRDLLIGDIHGR----SFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKV 448
Query: 834 NRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDH 893
+NG + +++ ++ P LA DW+ +KIY + NRI++ DGS R L ++
Sbjct: 449 FSVDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITEN 508
Query: 894 IDKPRDIVVNPEGGVMYWSDW---GASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVH 950
+ PR I V+P G +++SDW P +ERA MDG NRK L+ ++ WP G+ LD++
Sbjct: 509 LGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMIS 568
Query: 951 NRIYWTDGGNKTIEYANLDGTGRTKLIEN---LPHPFGLDLYGDEVFWTDWDTQSIQAAN 1007
R+YW D IE DG R ++ +PHPFG+ L+ +VF+TDW ++ AN
Sbjct: 569 KRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKAN 628
Query: 1008 KDTG--------AKRRTLG---------------CGKNNGGCSHLCLLKPG------GRS 1038
K T A R G C NNGGC +C+L G
Sbjct: 629 KFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFR 688
Query: 1039 CACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKN-ALGVD 1097
C C G +L+ D + C N+LIF+ +V IR I + DV++P+ + +G+D
Sbjct: 689 CKCTFGFQLDTDERHCI-AVQNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGID 747
Query: 1098 VDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNS 1157
D I+++D + I + GT E + N + + + D + +YWTD S
Sbjct: 748 FDAQDSTIFFSDMSKHMIFKQKIDGTGREILAANRVENVESLAFDWISKNLYWTDSHYKS 807
Query: 1158 IEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVD 1217
I V L + R+ +V L++PR++ +H GY+F++DW AKI RA DG++ +++
Sbjct: 808 ISVMRLADKTRRTVV-QYLNNPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVIN 866
Query: 1218 NKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTV--LSNVPYPYGIVIVGQHI 1275
+ WPNGLAID RLYW DA IE S FDG DRR + + + +P+G+ I G+H+
Sbjct: 867 TTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHL 926
Query: 1276 YWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQ-SERVLENACGT---DNGGCSH 1331
++TDW+ A+ R K + + VIR + ++ +++ + + NAC NG CSH
Sbjct: 927 FFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSH 986
Query: 1332 LCLRSP-LGYTCACPTGM 1348
C P C CP GM
Sbjct: 987 FCFPVPNFQRVCGCPYGM 1004
Score = 313 bits (768), Expect = 4e-84
Identities = 164/493 (33%), Positives = 259/493 (52%), Gaps = 28/493 (5%)
Query: 270 CKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDC 329
C N C +CD DC D +DE +C + C EF C +G+CIP + CD++ DC
Sbjct: 152 CDNGACYNTSQKCDWKVDCRDSSDEINCTEI---CLHNEFSCGNGECIPRAYVCDHDNDC 208
Query: 330 ADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQY 389
DG DE C + C ++TC RC+ + W+CDG DC + DE CE S D +
Sbjct: 209 QDGSDEHAC---NYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCE-SGPHDVH 264
Query: 390 TCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCS----AEEKCEKLCIT 445
C P+E + R C++ VCDG+ DCP +DE + CS + C+ C
Sbjct: 265 KCSPREWSCPESGR-CISIYKVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQYQCHE 323
Query: 446 TYDGHAACACPMGFLLAE-DKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILR 504
T G AC CP G+++ D +C + D+C +C Q C + G C C GYIL
Sbjct: 324 TPYG-GACFCPPGYIINHNDSRTCVEFDDCQIWG--ICDQKCESRPGRHLCHCEEGYILE 380
Query: 505 PDERSCKPT---GESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALD--YHYEKKLV 559
+ CK GE+ +++FSN + + G ++ +V+ + VA+ +HY + V
Sbjct: 381 RGQY-CKANDSFGEA-SIIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYHLQRV 438
Query: 560 FWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDG 619
FW++ + +N N+ +V+ +ETP +AVDW+++ ++ ++ R+++ LDG
Sbjct: 439 FWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDG 498
Query: 620 SKRAVLVANDLDKPRAIAVHPGDALVFWTDW---GPNPKIERADMDGDKRKTVIYDEIFW 676
S R L+ +L PR IAV P +F++DW PK+ERA MDG RK ++ ++ W
Sbjct: 499 SYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGW 558
Query: 677 PNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKG--LPHPFALTLFDDAIYWTD 734
P G+T+D ++YW D++ IE +DG R+ V G +PHPF ++LF+ +++TD
Sbjct: 559 PAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTD 618
Query: 735 WHTKSISTVNKNT 747
W ++ NK T
Sbjct: 619 WTKMAVLKANKFT 631
Score = 311 bits (763), Expect = 2e-83
Identities = 177/513 (34%), Positives = 261/513 (50%), Gaps = 33/513 (6%)
Query: 259 ELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCP-MVPGS--CNAGEFKCNDGK 315
E+ C F+C + CV + +CDG DC D +DE CP P C A F+C +
Sbjct: 3794 EMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKNHV 3853
Query: 316 CIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGE 375
CIP W+CD + DC DG DE + S + + C + RC+ +C+GV DC +G
Sbjct: 3854 CIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDGT 3913
Query: 376 DEMNCEVSCEE-DQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPL-KRKC 433
DE E C + C E+ N +C+ +VCD DC DE C K +
Sbjct: 3914 DE--TEEHCRKPTPKPCTEYEYKCGNG--HCIPHDNVCDDADDCGDWSDELGCNKGKERT 3969
Query: 434 SAEEKCEKLCITTYDGHAACACPMGF-LLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGS 492
AE CE+ C +G C+C GF D+ SC DI+EC EQ C Q C NT GS
Sbjct: 3970 CAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINEC--EQFGTCPQHCRNTKGS 4027
Query: 493 FRCGCMTGYILRPDE--RSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVAL 550
+ C C G+ D + C G SP LL + + IR+ L+ + + ++ A+
Sbjct: 4028 YECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQDEEYIQAV 4087
Query: 551 DYHYEK-----KLVFWS----ENNLRVIRVA-----QMNTKNMSDVIRWGLE---TPAGV 593
DY ++ +V+++ + I+ A + N+ + L+ P G+
Sbjct: 4088 DYDWDPXDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGI 4147
Query: 594 AVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPN 653
AVDW+ ++W+D +R+EVA LDG R L++ DLD+P AIAV+P L+FWTDWG
Sbjct: 4148 AVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKE 4207
Query: 654 PKIERADMDGDKRKTVIYDEIFWPNGLTIDY-TESKIYWADAKHHVIERAAFDGRDRRKV 712
PK E A M+G+ R ++++++ WP GL+IDY +IYW+D K VIE +DG DRR V
Sbjct: 4208 PKXESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRR-V 4266
Query: 713 TTKGLPHPFALTLFDDAIYWTDWHTKSISTVNK 745
K +P++L +F+D +YW + NK
Sbjct: 4267 IAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNK 4299
Score = 291 bits (713), Expect = 2e-77
Identities = 258/974 (26%), Positives = 414/974 (42%), Gaps = 108/974 (11%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEI-NCDVVK-TSLLVPSANASLNIGDVITNPTVLI 224
C S CI W+CD D DC D SDE +C +S + +N + +
Sbjct: 74 CQSEGQCIPSSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDC 133
Query: 225 ALTKPTVVIRYESFCAKKALDNAA----NPRSTWN----QPVELMRCAEI----DFECKN 272
+Y + C + DN A + + W + + C EI +F C N
Sbjct: 134 PDGADENDCQYPT-CEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGN 192
Query: 273 TKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADG 332
+C+P+ + CD DNDC D +DE +C +C +F C G+CI + W CD E DC D
Sbjct: 193 GECIPRAYVCDHDNDCQDGSDEHACNYP--TCGGYQFTCPSGRCIYQNWVCDGEDDCKDN 250
Query: 333 GDELNCK--PNSIRNCSLDEYTCADR-RCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQY 389
GDE C+ P+ + CS E++C + RC+ +CDG+ DC EDE N
Sbjct: 251 GDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMT 310
Query: 390 TCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRG-----DDEERCPLKRKCSAEEKCEKLCI 444
C N C + G CP G +D C C C++ C
Sbjct: 311 LCSAL-----NCQYQCHETPY--GGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKC- 362
Query: 445 TTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILR 504
+ G C C G++L +Y C+ D E + S +G G ++
Sbjct: 363 ESRPGRHLCHCEEGYILERGQY-CKANDS-FGEASIIFSNGRDLLIGDIH-GRSFRILVE 419
Query: 505 PDERSCKPTGESPTLLFSNRIGIRQVWL--TGDNYMSV-VKGLHNAVALDYHYEKK---L 558
R G + + F + R W + SV + GL+ L+ E
Sbjct: 420 SQNR-----GVAVGVAFHYHLQ-RVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLA 473
Query: 559 VFWSENNLRVI--RVAQMNTKNMSDVIRWGLET-----PAGVAVDWIHDLLFWTD----S 607
V W N + ++ +V +++ N+ R L T P G+AVD LF++D S
Sbjct: 474 VDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLS 533
Query: 608 GTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRK 667
G ++E A +DGS R LV L P + + V+W D IE DG +RK
Sbjct: 534 GEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVD-SRFDYIETVTYDGIQRK 592
Query: 668 TVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFD 727
TV++ P+ + E ++++ D + +A +V + P+ +T++
Sbjct: 593 TVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYH 652
Query: 728 DAI--YWTDWHTKS---------ISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKL 776
Y T+ + +S N G+G + +D R C +
Sbjct: 653 SLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFRC-KCTFGFQLDTDERHCIAV-QNF 710
Query: 777 LLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSA-VALDWDQKSNSIFWTDVEKDTINR 835
L+++ + +R D+++PV S V +D+D + ++IF++D+ K I +
Sbjct: 711 LIFSSQVAIRGIPFTLST---QEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFK 767
Query: 836 AYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSK-SDGSMRTLLAWDHI 894
++G+ + + + + LAFDWI+ +YWTD I V + +D + RT++ ++
Sbjct: 768 QKIDGTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV--QYL 825
Query: 895 DKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIY 954
+ PR +VV+P G ++++DW I RA DG + +I + WPNGLA+D +R+Y
Sbjct: 826 NNPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLY 885
Query: 955 WTDGGNKTIEYANLDGTGRTKL--IENLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGA 1012
W D IE++ DG R +L IE + HPFGL ++G+ +F+TDW +I K G
Sbjct: 886 WVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGG 945
Query: 1013 KRRTLGCG-------------------------KNNGGCSHLCLLKPG-GRSCACPIGIK 1046
+ + G NG CSH C P R C CP G++
Sbjct: 946 EMTVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMR 1005
Query: 1047 LNKDGKTCADGPIN 1060
L + TC P N
Sbjct: 1006 LASNHLTCEGDPTN 1019
Score = 242 bits (593), Expect = 7e-63
Identities = 126/335 (37%), Positives = 183/335 (54%), Gaps = 18/335 (5%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPI--NYLIFAHRVDIRVISLDVPYLIDV 1083
CS C G C C G DGKTC YLIF++R +R +++D Y +
Sbjct: 3163 CSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTID-GYFYSL 3221
Query: 1084 VLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDS 1143
+L L N + +D D +YW DT ++ I+R T+ ET+I + L A+ + +D
Sbjct: 3222 ILE--GLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDW 3279
Query: 1144 TGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDS--------PRAIALHYEYGYMFWSD 1195
RK+YW D + + V++L+G +R++L +D+ PR +ALH +YGY++W+D
Sbjct: 3280 VSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWAD 3339
Query: 1196 WGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDR 1255
WG A I R MDG N+ VI+ K++WPNG+ ID LYW DA + IE SD +GH R
Sbjct: 3340 WGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHR 3399
Query: 1256 RTVLSN-VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQS 1314
TV +P+P+ I I IYWTDW T+ + + +K + S+ + DI
Sbjct: 3400 HTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHP 3459
Query: 1315 ER--VLENACGTDNGGCSHLCLRSP--LGYTCACP 1345
R ++ N CGT+NGGCSHLCL P G+TC CP
Sbjct: 3460 YRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECP 3494
Score = 205 bits (501), Expect = 1e-51
Identities = 115/341 (33%), Positives = 177/341 (51%), Gaps = 20/341 (5%)
Query: 1329 CSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQ 1388
CS C Y C C G + + +T ++ S+ E +LIF+ R + ++++
Sbjct: 3163 CSQKCENVIGSYICKCAPG--YLREPDGKTCRQ-NSNIEPYLIFSNRYYLRNLTIDG--- 3216
Query: 1389 WDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGL 1448
+ +L ++ + N +A+D+ K +++ D VI + + N + +TII+ +L L
Sbjct: 3217 YFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFL-NKTNKETIINHRLPAAESL 3275
Query: 1449 GVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITGLTE---------PRALALFPAKGYL 1499
VDW++ +YW D + V+ L+G R++L + PR LAL P GYL
Sbjct: 3276 AVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYL 3335
Query: 1500 YWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLN 1559
YW+DWG YI R +DG+ + +I+ L +PNG+TIDY LYW DA I+ SDL
Sbjct: 3336 YWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLE 3395
Query: 1560 GQHRVQLVPDA-KNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIK 1618
G HR + A +PF +T F+D IYWTDW +++ + +K G N + +I
Sbjct: 3396 GHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIH 3455
Query: 1619 AVSADRQH-GWNPCKESNGGCSHLCLFR--GHEYICACPDD 1656
RQ NPC +NGGCSHLCL + G + C CPDD
Sbjct: 3456 VYHPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPDD 3496
Score = 200 bits (488), Expect = 4e-50
Identities = 98/281 (34%), Positives = 157/281 (55%), Gaps = 34/281 (12%)
Query: 796 IDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPA 855
ID + +E + + VALD+D+ ++W D ++ I R +LN +++ TI++ L
Sbjct: 3214 IDGYFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAE 3273
Query: 856 GLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHID--------KPRDIVVNPEGG 907
LA DW++ K+YW D + + VS +G R +LA +D PR + ++P+ G
Sbjct: 3274 SLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYG 3333
Query: 908 VMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYAN 967
+YW+DWG I R MDG N+ +I ++ WPNG+ +D ++ +YW D IEY++
Sbjct: 3334 YLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSD 3393
Query: 968 LDGTGRTKLIEN-LPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTL--------- 1017
L+G R + + LPHPF + ++ D ++WTDW+T++++ NK G+ R+TL
Sbjct: 3394 LEGHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFD 3453
Query: 1018 --------------GCGKNNGGCSHLCLLKPGGR--SCACP 1042
CG NNGGCSHLCL+KPGG+ +C CP
Sbjct: 3454 IHVYHPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECP 3494
Score = 181 bits (441), Expect = 2e-44
Identities = 117/361 (32%), Positives = 180/361 (49%), Gaps = 30/361 (8%)
Query: 1327 GGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEE-FLIFATRGSITYISLES 1385
G C C + Y C C G S +D+ K+C + L+ I +L S
Sbjct: 4015 GTCPQHCRNTKGSYECVCADGFT---SMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSS 4071
Query: 1386 PEQWDVTLPVKEVKNTIAVDYHWD-----LKMIFYT----DLDLNVIRSINMTNMSESKT 1436
E++ L +E AVDY WD L +++YT I+ + N +
Sbjct: 4072 -ERFSEYLQDEEYIQ--AVDYDWDPXDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRN 4128
Query: 1437 IISQKLET-------PNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLI-TGLTEPR 1488
+ Q+++ P+G+ VDW+ +IYW+D ++K IEVA+LDG RK LI T L +P
Sbjct: 4129 NLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPA 4188
Query: 1489 ALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDY-KERRLYWTD 1547
A+A+ P G ++W+DWG+ P E ++++G R I+V DLG+P GL+IDY R+YW+D
Sbjct: 4189 AIAVNPKLGLMFWTDWGKEPKXESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSD 4248
Query: 1548 ALKDRIDTSDLNGQHRVQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADK--RTGKNIT 1605
+D I+T +G R + +A NP+ + F+D +YW K + + +K + K T
Sbjct: 4249 FKEDVIETIKYDGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKT 4308
Query: 1606 LIRTNLEMAMEIKAVSADRQHGWNPCKESNGGCSHLCLFRGHEYICACPDDPDHVECSTV 1665
L+ + I + N CK+ CSHLCL R Y CACP +E ST
Sbjct: 4309 LVVNPWLTQVRIFHQLRYNKSVPNLCKQI---CSHLCLLRPGGYSCACPQGSSFIEGSTT 4365
Query: 1666 K 1666
+
Sbjct: 4366 E 4366
Score = 180 bits (439), Expect = 3e-44
Identities = 143/504 (28%), Positives = 223/504 (44%), Gaps = 54/504 (10%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPG-SCNAGEFKC-----NDGKC 316
C +F+C +C+P ++ CDGDNDCGD +DED +C+ EF C D +C
Sbjct: 2906 CLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRC 2965
Query: 317 IPERWRCDNERDCADGGDE-LNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGE 375
IP+ W CD + DC DG DE NC + R CS +E+TC C+ K + CD DC +
Sbjct: 2966 IPQSWVCDGDVDCTDGYDENQNC---TRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYS 3022
Query: 376 DEMNC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE--ERCPL-KR 431
DE C +C+++Q+TC+ N C+++ VCD DC G DE C +
Sbjct: 3023 DERGCLYQTCQQNQFTCQ-------NG--RCISKTFVCDEDNDCGDGSDELMHLCHTPEP 3073
Query: 432 KCSAEE-KCEK-LCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNT 489
C E KC+ CI + C L D+ C I+EC C C++T
Sbjct: 3074 TCPPHEFKCDNGRCI---EMMKLCNHLDDCLDNSDEKGC-GINECHDPSISGCDHNCTDT 3129
Query: 490 VGSFRCGCMTGYILRPDERSCKPTGESPTLLF------SNRIGIRQVWLTGDNYMSVVKG 543
+ SF C C GY L D+R+C E + F N IG + Y+ G
Sbjct: 3130 LTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIG-SYICKCAPGYLREPDG 3188
Query: 544 LHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLF 603
+ + E L+F + LR + + +I GL+ + D + L+
Sbjct: 3189 --KTCRQNSNIEPYLIFSNRYYLRNLTI----DGYFYSLILEGLDNVVALDFDRVEKRLY 3242
Query: 604 WTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDG 663
W D+ + +E L+ + + ++ + L ++AV ++W D + +D++G
Sbjct: 3243 WIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLD-ARLDGLFVSDLNG 3301
Query: 664 DKRK-----TVIYDEIFW---PNGLTIDYTESKIYWADAKHHV-IERAAFDGRDRRKVTT 714
R+ V + F P GL + +YWAD H I R DG ++ + +
Sbjct: 3302 GHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIIS 3361
Query: 715 KGLPHPFALTL--FDDAIYWTDWH 736
L P +T+ +D +YW D H
Sbjct: 3362 TKLEWPNGITIDYTNDLLYWADAH 3385
Score = 170 bits (414), Expect = 3e-41
Identities = 120/357 (33%), Positives = 170/357 (47%), Gaps = 29/357 (8%)
Query: 1024 GGCSHLCLLKPGGRSCACPIGIKLNKD--GKTCA-DGPINYLIFAHRVDIRVISLDVPYL 1080
G C C G C C G D GK CA +G L+ V IR +L
Sbjct: 4015 GTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERF 4074
Query: 1081 IDVVLPLPPLKNALGVDVD-HSTGL--IYWTDTGQRK----IQRA---------TRLGTH 1124
+ + ++ A+ D D GL +Y+T G+ I+RA L
Sbjct: 4075 SEYLQDEEYIQ-AVDYDWDPXDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQE 4133
Query: 1125 VETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIAL 1184
V+ + + DGI +D GR IYW+D IEVA+LDGR RK L+ T LD P AIA+
Sbjct: 4134 VDLKLKYVMQP-DGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAV 4192
Query: 1185 HYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEG-RLYWNDAKIL 1243
+ + G MFW+DWG K E A M+G +R ++V + WP GL+ID + R+YW+D K
Sbjct: 4193 NPKLGLMFWTDWGKEPKXESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKED 4252
Query: 1244 TIESSDFDGHDRRTVLSNVPYPYGIVIVGQHIYWTDWKTKALHRADK---TNASDPIVIR 1300
IE+ +DG DRR + PY + I +YW + + + +K +V+
Sbjct: 4253 VIETIKYDGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVN 4312
Query: 1301 KNLEGLMDIRAIQSERVLENACGTDNGGCSHLCLRSPLGYTCACPTGMPF-EKSTTD 1356
L + ++ + + N C CSHLCL P GY+CACP G F E STT+
Sbjct: 4313 PWLTQVRIFHQLRYNKSVPNLC---KQICSHLCLLRPGGYSCACPQGSSFIEGSTTE 4366
Score = 167 bits (407), Expect = 2e-40
Identities = 161/628 (25%), Positives = 263/628 (41%), Gaps = 73/628 (11%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
+ CD R C S + CI +W CDG DC D +DEI C VV + G
Sbjct: 26 QECDSAHFR--CGSGH-CIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSE---GQ 79
Query: 216 VITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKC 275
I + + V + C D+ ++ R +Q C+ C N +C
Sbjct: 80 CIPS----------SWVCDQDQDC-----DDGSDERQDCSQST----CSSHQITCSNGQC 120
Query: 276 VPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDE 335
+P +++CD DC D DE+ C P +C + C++G C +CD + DC D DE
Sbjct: 121 IPSEYRCDHVRDCPDGADENDC-QYP-TCE--QLTCDNGACYNTSQKCDWKVDCRDSSDE 176
Query: 336 LNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV-SCEEDQYTCRPQ 394
+NC + N E++C + C+ + ++CD DC +G DE C +C Q+TC P
Sbjct: 177 INCTEICLHN----EFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTC-PS 231
Query: 395 EHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPL----KRKCSAEE-KCEK--LCITTY 447
C+ + VCDG DC DE+ C KCS E C + CI+ Y
Sbjct: 232 --------GRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIY 283
Query: 448 DGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV--CSQTCSNTVGSFRCGCMTGYIL-R 504
C + ED+ + C C C T C C GYI+
Sbjct: 284 ---KVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYIINH 340
Query: 505 PDERSCKPTGESP-----TLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLV 559
D R+C + +R G R + + Y+ + +G + A D E ++
Sbjct: 341 NDSRTCVEFDDCQIWGICDQKCESRPG-RHLCHCEEGYI-LERGQY-CKANDSFGEASII 397
Query: 560 FWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDG 619
F + +L + + + + + + G+ GVA + +FWTD+ +V ++G
Sbjct: 398 FSNGRDLLIGDIHGRSFRILVESQNRGV--AVGVAFHYHLQRVFWTDTVQNKVFSVDING 455
Query: 620 SKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNG 679
++ ++ P +AV + ++ + N +I+ ++DG R T+I + + P G
Sbjct: 456 LNIQEVLNVSVETPENLAVDWVNNKIYLVETKVN-RIDMVNLDGSYRVTLITENLGHPRG 514
Query: 680 LTIDYTESKIYWAD----AKHHVIERAAFDGRDRRK-VTTK-GLPHPFALTLFDDAIYWT 733
+ +D T ++++D + +ERA DG +R+ V TK G P L + +YW
Sbjct: 515 IAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWV 574
Query: 734 DWHTKSISTVNKNTGMGIQTVHAGLNVP 761
D I TV + VH G +P
Sbjct: 575 DSRFDYIETVTYDGIQRKTVVHGGSLIP 602
Score = 167 bits (407), Expect = 2e-40
Identities = 82/227 (36%), Positives = 116/227 (51%), Gaps = 20/227 (8%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
+C F CKN +CVP + CDG +DC D +DE C + +C++ F C G+CIP W
Sbjct: 1025 QCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHW 1084
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCE 381
RCD DC DG DE NC ++ +C +YTC + +C+ K W+CD DC +G DE NC
Sbjct: 1085 RCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCN 1144
Query: 382 VSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPL-----KRKCSAE 436
S E TC+P + N C++ VCDG KDC G DE C L + KC++
Sbjct: 1145 -STE----TCQPSQFNCPN--HRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASG 1197
Query: 437 EKC---EKLCITTYD-----GHAACACPMGFLLAEDKYSCRDIDECM 475
+KC C +D A C + D++ C++ C+
Sbjct: 1198 DKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICI 1244
Score = 158 bits (384), Expect = 1e-37
Identities = 86/228 (37%), Positives = 120/228 (52%), Gaps = 22/228 (9%)
Query: 854 PAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSD 913
P G+A DW+ IYW+D RIEV+K DG R L +D+P I VNP+ G+M+W+D
Sbjct: 4144 PDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTD 4203
Query: 914 WGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHN-RIYWTDGGNKTIEYANLDGTG 972
WG P E A M+G +R L+F + WP GL++D ++N RIYW+D IE DGT
Sbjct: 4204 WGKEPKXESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTD 4263
Query: 973 RTKLIENLPHPFGLDLYGDEVFWTDWDTQSIQAANK-DTGAKRRTLGCG----------- 1020
R + + +P+ LD++ D+++W + + NK G K +TL
Sbjct: 4264 RRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFHQ 4323
Query: 1021 -KNNGG--------CSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPI 1059
+ N CSHLCLL+PGG SCACP G + T D I
Sbjct: 4324 LRYNKSVPNLCKQICSHLCLLRPGGYSCACPQGSSFIEGSTTECDAAI 4371
Score = 151 bits (366), Expect = 2e-35
Identities = 89/269 (33%), Positives = 122/269 (45%), Gaps = 28/269 (10%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
C+ + CD NDCGD SDE C L NA+ +
Sbjct: 2753 CVQYSYRCDYYNDCGDGSDEAGC-------LFRDCNATTEF------------MCNNRRC 2793
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTK-CVPKDFQCDGDNDCGDW 291
I E C +DN + ++ + C +C N+ C+P+ + CDGDNDCGD
Sbjct: 2794 IPREFIC--NGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDN 2851
Query: 292 TDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEY 351
+DE+ +C++ EF+C G+CIP+ W CD E DC D DE +S R C DE+
Sbjct: 2852 SDENPTYCTTHTCSSSEFQCTSGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEF 2911
Query: 352 TCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSN---AFRNCVNR 408
C RC+ W+CDG DC + DE + C+ C E L N R C+ +
Sbjct: 2912 KCDGGRCIPSEWICDGDNDCGDMSDE-DKRHQCQNQ--NCSDSEFLCVNDRPPDRRCIPQ 2968
Query: 409 KHVCDGMKDCPRGDDEERCPLKRKCSAEE 437
VCDG DC G DE + +R CS E
Sbjct: 2969 SWVCDGDVDCTDGYDENQNCTRRTCSENE 2997
Score = 150 bits (363), Expect = 5e-35
Identities = 137/518 (26%), Positives = 213/518 (41%), Gaps = 56/518 (10%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C E +F C N +C+P + CD NDCGD +DE C M +C+ F+C G C+ +
Sbjct: 3759 CTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEM--RTCHPEYFQCTSGHCVHSELK 3816
Query: 323 CDNERDCADGGDELNCKPNSIRN---CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMN 379
CD DC D DE +C P + C + C + C+ W CDG DC +G DE
Sbjct: 3817 CDGSADCLDASDEADC-PTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDE-- 3873
Query: 380 CEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDD--EERC--PLKRKCSA 435
E+ D P N C+ VC+G+ DC G D EE C P + C+
Sbjct: 3874 -ELHLCLDVPCNSPNRFRCDN--NRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTE 3930
Query: 436 -EEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSN-TVGSF 493
E KC +D A G D+ C E ++ +C Q C+ G F
Sbjct: 3931 YEYKCGNGHCIPHDNVCDDADDCGDW--SDELGCNKGKERTCAEN-ICEQNCTQLNEGGF 3987
Query: 494 RCGCMTGYILRPDERS-------CKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHN 546
C C G+ +R+ C+ G P + + V G MS G
Sbjct: 3988 ICSCTAGFETNVFDRTSCLDINECEQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRC 4047
Query: 547 AVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIH-----DL 601
A + +N+R IR ++++ S+ ++ E V DW +
Sbjct: 4048 AAE-----GSSPLLLLPDNVR-IRKYNLSSERFSEYLQ-DEEYIQAVDYDWDPXDIGLSV 4100
Query: 602 LFWTDSG-------TRRVEVATLDGSKRAVLVANDLD-----KPRAIAVHPGDALVFWTD 649
+++T G +R + + + ++ DL +P IAV ++W+D
Sbjct: 4101 VYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSD 4160
Query: 650 WGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWAD-AKHHVIERAAFDGRD 708
N +IE A +DG RK +I ++ P + ++ ++W D K E A +G D
Sbjct: 4161 -VKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKXESAWMNGED 4219
Query: 709 RRKVTTKGLPHPFALT---LFDDAIYWTDWHTKSISTV 743
R + + L P L+ L +D IYW+D+ I T+
Sbjct: 4220 RNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETI 4257
Score = 147 bits (357), Expect = 3e-34
Identities = 87/254 (34%), Positives = 120/254 (47%), Gaps = 27/254 (10%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
CI W CD DNDCGD SDE + +S ++ D N T T +
Sbjct: 3647 CIPQAWKCDVDNDCGDHSDEP----------IEECMSSAHLCD---NFTEFSCKTNYRCI 3693
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEI-DFECKNTKCVPKDFQCDGDNDCGDW 291
++ + C +D+ + ++ Q E C + DF CKN C+P +QCDG NDCGD
Sbjct: 3694 PKW-AVC--NGVDDCRD--NSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDN 3748
Query: 292 TDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEY 351
+DE++C P C EF+C + +CIP RW CD+ DC D DE +C+ +R C + +
Sbjct: 3749 SDEENC--APRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCE---MRTCHPEYF 3803
Query: 352 TCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHV 411
C CV CDG DC + DE +C + Y C+ N C+
Sbjct: 3804 QCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGAY-CQATMFECKN--HVCIPPYWK 3860
Query: 412 CDGMKDCPRGDDEE 425
CDG DC G DEE
Sbjct: 3861 CDGDDDCGDGSDEE 3874
Score = 147 bits (355), Expect = 5e-34
Identities = 116/474 (24%), Positives = 212/474 (44%), Gaps = 34/474 (7%)
Query: 255 NQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDG 314
NQ C+E +F C C+PK F+CD NDCGD++DE C + +C +F C +G
Sbjct: 2985 NQNCTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGC--LYQTCQQNQFTCQNG 3042
Query: 315 KCIPERWRCDNERDCADGGDEL-NCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTN 373
+CI + + CD + DC DG DEL + C E+ C + RC+ LC+ + DC +
Sbjct: 3043 RCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLD 3102
Query: 374 GEDEMNCEVS-CEEDQYT-CRPQ-EHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLK 430
DE C ++ C + + C +++ + +C + + C D +E +
Sbjct: 3103 NSDEKGCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCV--DIDECTEMP 3160
Query: 431 RKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCR---DIDECMYEQDPVCSQTCS 487
CS +KCE + G C C G+L D +CR +I+ + + +
Sbjct: 3161 FVCS--QKCENVI-----GSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNL- 3212
Query: 488 NTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVK-GLHN 546
T+ + + + + + + R I +++L N +++ L
Sbjct: 3213 -TIDGYFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPA 3271
Query: 547 AVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIR--------WGLETPAGVAVDWI 598
A +L + + ++W + L + V+ +N + + + + + P G+A+
Sbjct: 3272 AESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQ 3331
Query: 599 HDLLFWTDSGTRR-VEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIE 657
+ L+W D G R + +DG+ ++V+++ L+ P I + + L++W D IE
Sbjct: 3332 YGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWAD-AHLGYIE 3390
Query: 658 RADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERA-AFDGRDRR 710
+D++G R TV YD P+ I E IYW D +E+ +DG +R+
Sbjct: 3391 YSDLEGHHRHTV-YDGAL-PHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQ 3442
Score = 136 bits (329), Expect = 7e-31
Identities = 64/186 (34%), Positives = 98/186 (52%), Gaps = 11/186 (5%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C +++C N +C+P+ +QCD NDC D +DEDS +C G+F+C +G+CIP+ W+
Sbjct: 3594 CDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWK 3653
Query: 323 CDNERDCADGGDE--LNCKPNSIRNCSLDEYTC-ADRRCVLKTWLCDGVRDCTNGEDEMN 379
CD + DC D DE C ++ + E++C + RC+ K +C+GV DC + DE
Sbjct: 3654 CDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQG 3713
Query: 380 CEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKC 439
CE + TC P +C+ + CDG DC DEE C + +E +C
Sbjct: 3714 CE------ERTCHPVGDFRCKN-HHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRC 3766
Query: 440 -EKLCI 444
+ CI
Sbjct: 3767 VNQQCI 3772
Score = 130 bits (313), Expect = 6e-29
Identities = 100/334 (29%), Positives = 143/334 (42%), Gaps = 46/334 (13%)
Query: 169 STNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTK 228
S CI+ EW CD DNDCGD SDE+ V P+A N G + +
Sbjct: 2708 SNGRCISEEWKCDNDNDCGDGSDEME-SVCALHTCSPTAFTCAN-GRCV----------Q 2755
Query: 229 PTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDC 288
+ Y + C + D A N E M C N +C+P++F C+G ++C
Sbjct: 2756 YSYRCDYYNDCGDGS-DEAGCLFRDCNATTEFM--------CNNRRCIPREFICNGVDNC 2806
Query: 289 GD--WTDEDSCPMVPGSCNAGEFKC-NDGKCIPERWRCDNERDCADGGDELNCKPNSIRN 345
D +DE +CP +C +G KC N CIP + CD + DC D DE N +
Sbjct: 2807 HDNNTSDEKNCP--DRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDE-NPTYCTTHT 2863
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNC 405
CS E+ C RC+ + W CD DC + DE SC + TC E C
Sbjct: 2864 CSSSEFQCTSGRCIPQHWYCDQETDCFDASDE---PASCGHSERTCLADEFKCDGG--RC 2918
Query: 406 VNRKHVCDGMKDCPRGDDEERCPLKRKCSAE--EKCEKLCITTYDGHAACACPMGFLLAE 463
+ + +CDG DC DE++ + +C + E LC+ C P ++
Sbjct: 2919 IPSEWICDGDNDCGDMSDEDK---RHQCQNQNCSDSEFLCVNDRPPDRRC-IPQSWVCDG 2974
Query: 464 DKYSCRDIDECMYEQDPVCS-QTCSNTVGSFRCG 496
D C D Y+++ C+ +TCS F CG
Sbjct: 2975 D-VDCTD----GYDENQNCTRRTCSE--NEFTCG 3001
Score = 128 bits (308), Expect = 2e-28
Identities = 66/174 (37%), Positives = 90/174 (51%), Gaps = 19/174 (10%)
Query: 257 PVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKC-NDGK 315
P C F C + C+P D++CDG DC D DE C +V +C G FKC ++G+
Sbjct: 22 PASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVV--TCQQGYFKCQSEGQ 79
Query: 316 CIPERWRCDNERDCADGGDE-LNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNG 374
CIP W CD ++DC DG DE +C ++ CS + TC++ +C+ + CD VRDC +G
Sbjct: 80 CIPSSWVCDQDQDCDDGSDERQDCSQST---CSSHQITCSNGQCIPSEYRCDHVRDCPDG 136
Query: 375 EDEMNCEV-SCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC 427
DE +C+ +CE Q TC N C N CD DC DE C
Sbjct: 137 ADENDCQYPTCE--QLTC-------DNG--ACYNTSQKCDWKVDCRDSSDEINC 179
Score = 126 bits (303), Expect = 1e-27
Identities = 64/184 (34%), Positives = 95/184 (51%), Gaps = 17/184 (9%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
RC F C N +C+ ++++CD DNDCGD +DE +C+ F C +G+C+ +
Sbjct: 2699 RCGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSY 2758
Query: 322 RCDNERDCADGGDELNCKPNSIRNC-SLDEYTCADRRCVLKTWLCDGVRDC--TNGEDEM 378
RCD DC DG DE C R+C + E+ C +RRC+ + ++C+GV +C N DE
Sbjct: 2759 RCDYYNDCGDGSDEAGC---LFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEK 2815
Query: 379 NC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEE--RCPLKRKCSA 435
NC + +C+ C SN C+ R ++CDG DC DE C S+
Sbjct: 2816 NCPDRTCQSGYTKCH-----NSNI---CIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSS 2867
Query: 436 EEKC 439
E +C
Sbjct: 2868 EFQC 2871
Score = 108 bits (259), Expect = 2e-22
Identities = 52/171 (30%), Positives = 79/171 (46%), Gaps = 4/171 (2%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C F+C + C C+ +C D +DED C++ E++C + +CIPE W+
Sbjct: 3553 CRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQ 3612
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV 382
CD DC D DE + + R C ++ CA+ RC+ + W CD DC + DE E
Sbjct: 3613 CDTFNDCEDNSDE-DSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEE- 3670
Query: 383 SCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKC 433
C + C C+ + VC+G+ DC DE+ C +R C
Sbjct: 3671 -CMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCE-ERTC 3719
Score = 103 bits (247), Expect = 6e-21
Identities = 86/301 (28%), Positives = 119/301 (39%), Gaps = 47/301 (15%)
Query: 166 ICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIA 225
+C + CI + W CDG DC D SDE+ + L + G+ + T+ A
Sbjct: 3518 LCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRL---GQFQCSDGNCTSPQTLCNA 3574
Query: 226 LTK-PTVVIRYESFCAKKALDN----AANPR---STWNQPVELMRCAEIDFE----CKNT 273
P C D+ AN R +W Q C + E C +
Sbjct: 3575 HQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESW-QCDTFNDCEDNSDEDSSHCASR 3633
Query: 274 KCVPKDFQC------------DGDNDCGDWTDE--DSCPMVPGSC-NAGEFKCNDG-KCI 317
C P F+C D DNDCGD +DE + C C N EF C +CI
Sbjct: 3634 TCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCI 3693
Query: 318 PERWRCDNERDCADGGDELNCKPNSIRNC-SLDEYTCADRRCVLKTWLCDGVRDCTNGED 376
P+ C+ DC D DE C+ R C + ++ C + C+ W CDG DC + D
Sbjct: 3694 PKWAVCNGVDDCRDNSDEQGCEE---RTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSD 3750
Query: 377 EMNCEV-SCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSA 435
E NC C E ++ C Q+ C+ + +CD DC DE C + R C
Sbjct: 3751 EENCAPRECTESEFRCVNQQ---------CIPSRWICDHYNDCGDNSDERDCEM-RTCHP 3800
Query: 436 E 436
E
Sbjct: 3801 E 3801
Score = 90.2 bits (214), Expect = 6e-17
Identities = 73/277 (26%), Positives = 113/277 (40%), Gaps = 44/277 (15%)
Query: 254 WNQPVELMRCAEIDFECKNTKCVP---KDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFK 310
+ QP+ C + C + + K F C+ +D S +P C++ +F
Sbjct: 3460 YRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMP-MCSSTQFL 3518
Query: 311 C-NDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVR 369
C N+ KCIP W+CD ++DC+DG DEL P R C L ++ C+D C LC+ +
Sbjct: 3519 CANNEKCIPIWWKCDGQKDCSDGSDELALCPQ--RFCRLGQFQCSDGNCTSPQTLCNAHQ 3576
Query: 370 DCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEE---- 425
+C +G DE + CE + C E +N + C+ CD DC DE+
Sbjct: 3577 NCPDGSDE--DRLLCE--NHHCDSNEWQCAN--KRCIPESWQCDTFNDCEDNSDEDSSHC 3630
Query: 426 ----------RC------PLKRKCSAEEKC-----EKL--CITT---YDGHAACACPMGF 459
RC P KC + C E + C+++ D +C +
Sbjct: 3631 ASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNY 3690
Query: 460 LLAEDKYSCRDIDECMYEQDPV-CSQTCSNTVGSFRC 495
C +D+C D C + + VG FRC
Sbjct: 3691 RCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRC 3727
Score = 68.5 bits (160), Expect = 2e-10
Identities = 37/114 (32%), Positives = 54/114 (47%), Gaps = 7/114 (6%)
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCE 381
+C +E + + +C ++ C +TC++ RC+ + W CD DC +G DEM E
Sbjct: 2676 QCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGRCISEEWKCDNDNDCGDGSDEM--E 2733
Query: 382 VSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSA 435
C +TC P +N CV + CD DC G DE C L R C+A
Sbjct: 2734 SVCA--LHTCSPTAFTCANG--RCVQYSYRCDYYNDCGDGSDEAGC-LFRDCNA 2782
Score = 65.7 bits (153), Expect = 1e-09
Identities = 64/247 (25%), Positives = 87/247 (35%), Gaps = 24/247 (9%)
Query: 111 DDAGC-ITPCLKINFSCQISCTCIPMEK--RXXXXXXXXXXXXXXXXXRSCDEHENRTIC 167
D+ GC + C + F CQ CIP +C H+ I
Sbjct: 58 DEIGCAVVTCQQGYFKCQSEGQCIPSSWVCDQDQDCDDGSDERQDCSQSTCSSHQ---IT 114
Query: 168 HSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIG---DVITNPTVLI 224
S CI E+ CD DC D +DE +C L A N D +
Sbjct: 115 CSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSS 174
Query: 225 ALTKPTVVIRYESF------CAKKAL----DNAANPRSTWNQPVELMRCAEIDFECKNTK 274
T + + F C +A DN S C F C + +
Sbjct: 175 DEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSD-EHACNYPTCGGYQFTCPSGR 233
Query: 275 CVPKDFQCDGDNDCGDWTDEDSCPMVP---GSCNAGEFKC-NDGKCIPERWRCDNERDCA 330
C+ +++ CDG++DC D DED C P C+ E+ C G+CI CD DC
Sbjct: 234 CIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCP 293
Query: 331 DGGDELN 337
DE N
Sbjct: 294 GREDENN 300
Score = 65.3 bits (152), Expect = 2e-09
Identities = 43/180 (23%), Positives = 85/180 (47%), Gaps = 8/180 (4%)
Query: 796 IDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPA 855
+ +D+ + +A+DW I+W+DV+ I A L+G ++ ++ ++L PA
Sbjct: 4131 VQEVDLKLKYVMQPDGIAVDW--VGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPA 4188
Query: 856 GLAFDWITDKIYWTDGGTN-RIEVSKSDGSMRTLLAWDHIDKPRDIVVN-PEGGVMYWSD 913
+A + ++WTD G + E + +G R +L ++ + P + ++ +YWSD
Sbjct: 4189 AIAVNPKLGLMFWTDWGKEPKXESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSD 4248
Query: 914 WGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGR 973
+ IE DG +R+ + M N +LD+ +++YW + N G G+
Sbjct: 4249 F-KEDVIETIKYDGTDRRVIAKEAM---NPYSLDIFEDQLYWISKEKGEVWKQNKFGQGK 4304
Score = 65.3 bits (152), Expect = 2e-09
Identities = 40/157 (25%), Positives = 81/157 (51%), Gaps = 6/157 (3%)
Query: 559 VFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTR-RVEVATL 617
++WS+ + I VA+++ + +I L+ PA +AV+ L+FWTD G + E A +
Sbjct: 4156 IYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKXESAWM 4215
Query: 618 DGSKRAVLVANDLDKPRAIAV-HPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFW 676
+G R +LV DL P +++ + + ++W+D+ IE DG R+ + + +
Sbjct: 4216 NGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDF-KEDVIETIKYDGTDRRVIAKEAM-- 4272
Query: 677 PNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVT 713
N ++D E ++YW + + + G+ +++ T
Sbjct: 4273 -NPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKT 4308
Score = 64.5 bits (150), Expect = 3e-09
Identities = 44/154 (28%), Positives = 66/154 (42%), Gaps = 26/154 (16%)
Query: 340 PNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV-SCEEDQYTCRPQEHLM 398
P S + C + C C+ W CDG +DC++ DE+ C V +C++ + C+ +
Sbjct: 22 PASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQ-- 79
Query: 399 SNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE-KCEK-LCI-TTYDGHAACAC 455
C+ VCD +DC G DE + + CS+ + C CI + Y C
Sbjct: 80 ------CIPSSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDC 133
Query: 456 PMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSN 488
P G D ++C Y P C Q TC N
Sbjct: 134 PDG----------ADENDCQY---PTCEQLTCDN 154
Score = 46.4 bits (105), Expect = 0.001
Identities = 59/234 (25%), Positives = 82/234 (35%), Gaps = 31/234 (13%)
Query: 91 KAIDVIHTDPDDGPLNEGTEDDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXX 150
+ ID+ D +G+ D+ GC+ C F C CI + R
Sbjct: 1160 RCIDLSFVCDGDKDCVDGS-DEVGCVLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSD 1218
Query: 151 XXXXXRSCDE--HENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSAN 208
H + C +CI W CDG DC SDE N V KT PS+
Sbjct: 1219 EAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKT---CPSSY 1275
Query: 209 ASLNIGDVITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQ-PVELMRCAEID 267
+ G+ I + C + DN S P + RC
Sbjct: 1276 FHCDNGNCIHRXWL----------------CDR---DNDCGDMSDEKDCPTQPFRCPSWQ 1316
Query: 268 FEC-KNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPG-SCNAGEFKCNDGKCIPE 319
++C + CV CDG DC + TDE P+ G SC+ C +C+ E
Sbjct: 1317 WQCLGHNICVNLSVVCDGIFDCPNGTDES--PLCNGNSCSDFNGGCTH-ECVQE 1367
Score = 46.0 bits (104), Expect = 0.001
Identities = 32/99 (32%), Positives = 40/99 (40%), Gaps = 9/99 (9%)
Query: 99 DPDDGPLNEGTEDDAGCIT-PCLKINFSCQISCTCIPM----EKRXXXXXXXXXXXXXXX 153
D D+ + E+ C T C F C S CIP ++
Sbjct: 2843 DGDNDCGDNSDENPTYCTTHTCSSSEFQCT-SGRCIPQHWYCDQETDCFDASDEPASCGH 2901
Query: 154 XXRSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDE 192
R+C E + C CI EW+CDGDNDCGD SDE
Sbjct: 2902 SERTCLADEFK--CDGGR-CIPSEWICDGDNDCGDMSDE 2937
Score = 43.2 bits (97), Expect = 0.009
Identities = 19/42 (45%), Positives = 24/42 (57%), Gaps = 3/42 (7%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDV 197
R C E E R + CI W+CD NDCGD SDE +C++
Sbjct: 3757 RECTESEFRCV---NQQCIPSRWICDHYNDCGDNSDERDCEM 3795
Score = 39.5 bits (88), Expect = 0.11
Identities = 15/22 (68%), Positives = 17/22 (77%)
Query: 171 NVCIALEWLCDGDNDCGDFSDE 192
+VCI W CDGD+DCGD SDE
Sbjct: 3852 HVCIPPYWKCDGDDDCGDGSDE 3873
Score = 37.5 bits (83), Expect = 0.43
Identities = 29/110 (26%), Positives = 46/110 (41%), Gaps = 6/110 (5%)
Query: 86 RPSLQKAIDVIHTDPDDGPLNEGTEDDAGCIT-PCLKINFSCQISCTCIPMEKRXXXXXX 144
RP ++ I D +G +++ C C + F+C CIP R
Sbjct: 2959 RPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGL-CIPKIFRCDRHND 3017
Query: 145 XXXXXXXXX-XXRSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEI 193
++C + N+ C + CI+ ++CD DNDCGD SDE+
Sbjct: 3018 CGDYSDERGCLYQTCQQ--NQFTCQNGR-CISKTFVCDEDNDCGDGSDEL 3064
Score = 37.1 bits (82), Expect = 0.57
Identities = 18/40 (45%), Positives = 23/40 (57%), Gaps = 3/40 (7%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINC 195
R+C E+E C +CI + CD NDCGD+SDE C
Sbjct: 2991 RTCSENE--FTC-GYGLCIPKIFRCDRHNDCGDYSDERGC 3027
Score = 36.3 bits (80), Expect = 1.00
Identities = 16/41 (39%), Positives = 27/41 (65%), Gaps = 3/41 (7%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCD 196
+ C E+E + C + + CI + +CD +DCGD+SDE+ C+
Sbjct: 3926 KPCTEYEYK--CGNGH-CIPHDNVCDDADDCGDWSDELGCN 3963
>AC007556-2|AAX88965.1| 3881|Homo sapiens unknown protein.
Length = 3881
Score = 603 bits (1490), Expect = e-171
Identities = 473/1634 (28%), Positives = 743/1634 (45%), Gaps = 156/1634 (9%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
CI L ++CDGD DC D SDE+ C + T+ A+ IG +TN +
Sbjct: 387 CIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIG--VTNRCDGV-------- 436
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTK-CVPKDFQCDGDNDCGDW 291
F D A P +P + C +F+C+ C+P ++CDG DC
Sbjct: 437 -----FDCSDNSDEAGCP----TRPPGM--CHSDEFQCQEDGICIPNFWECDGHPDCLYG 485
Query: 292 TDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEY 351
+DE + VP +C + F C++G CI W CD + DC D DE +C R C ++
Sbjct: 486 SDEHNA-CVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFR-CPSWQW 543
Query: 352 TCADRR-CVLKTWLCDGVRDCTNGEDEMN-CEV-SCEEDQYTCRPQEHLMSNAFRNCVNR 408
C CV + +CDG+ DC NG DE C SC + C + CV
Sbjct: 544 QCLGHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHE----------CVQE 593
Query: 409 KHVCDGMKDCPRG----DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAED 464
+ CP G +D + C +C C + C G C+C G++L D
Sbjct: 594 PFGAKCL--CPLGFLLANDSKTCEDIDECDILGSCSQHCYNMR-GSFRCSCDTGYMLESD 650
Query: 465 KYSCR-DIDECMY----EQDPVCSQTCSNTVGSFRCGCMTG-YILRPDERSCK------- 511
+C+ E + Q+ + + + ++ V + G YI+ D S
Sbjct: 651 GRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSD 710
Query: 512 PTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLVFWSENNLRVIRV 571
T F N R V+ D+ S++ L +A+D+ + ++W++ L I V
Sbjct: 711 ATQGKTWSAFQNGTDRRVVF---DS--SII--LTETIAIDW--VGRNLYWTDYALETIEV 761
Query: 572 AQMNTKNMSDVIRWGLETPAGVAVD--WIHDLLFWTDSGTR-RVEVATLDGSKRAVLVAN 628
++++ + + +I L P G+A+D LLFW+D G R+E A++DGS R V+V +
Sbjct: 762 SKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQD 821
Query: 629 DLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESK 688
+ P + + + L+++ D ++ D +G R+ VI ++ + + E
Sbjct: 822 KIFWPCGLTIDYPNRLLYFMD-SYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDS 880
Query: 689 IYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTG 748
+YW D + RA + V + P + + + + S +
Sbjct: 881 VYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFSRCSHLCL 940
Query: 749 MGIQTVH-------AGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDM 801
+ Q H +G ++ D+ +C + L+ R+ + L + + S D
Sbjct: 941 LSSQGPHFYSCVCPSGWSLSPDL--LNCLRDDQPFLITVRQHIIFGISLNPE--VKSNDA 996
Query: 802 VIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPA-GLAFD 860
++P+ I++ + +++D I+W + I+R +G+++T +++ P+ LA D
Sbjct: 997 MVPIAGIQNGLDVEFDDAEQYIYWVE-NPGEIHRVKTDGTNRTVFASISMVGPSMNLALD 1055
Query: 861 WITDKIYWTDGGTNRIEVSKSDGSMR---TLLAWDH----IDKPRDIVVNPEGGVMYWSD 913
WI+ +Y T+ T IEV G +R TL+A D + P I V+P G +YWSD
Sbjct: 1056 WISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSD 1115
Query: 914 WGAS---PC-IERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLD 969
G P I A+MDG + K L G + + LD+ ++YW G IE N+D
Sbjct: 1116 QGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVD 1175
Query: 970 GTGRTKLIENLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTL------------ 1017
GT R L+ L HP+G+ ++ +++TD + I+ +K TGA + L
Sbjct: 1176 GTDRMILVHQLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGLQV 1235
Query: 1018 -----------GCGKNNGGCSHLCLLKPGGR-SCACPIGIKLNKDGKTCADGPINYLIFA 1065
GC N C +CL PGG SCAC G KLN D ++C+ P N I
Sbjct: 1236 YHRRNAAESSNGCSNNMNACQQICLPVPGGLFSCACATGFKLNPDNRSCS--PYNSFIVV 1293
Query: 1066 HRVD-IRVISLDVPYLIDVVLPLPPL-KNALGVDVDHSTGLIYWTD-----TGQRKIQRA 1118
+ IR SL++ + ++P+ +NAL VDVD S+G IYW D I+R
Sbjct: 1294 SMLSAIRGFSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASDNAIRRI 1353
Query: 1119 TRLGTHVETVIGNGL--HTADGIVIDSTGRKIYWTDG--GRNSIEVAELDGRNRKVLVWT 1174
G+ + ++ +G+ + GI +D +Y+T+ IEV ++ R+VL+
Sbjct: 1354 KPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKV 1413
Query: 1175 GLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGR 1234
+D PR I + + Y+FW+D+G KIER+ +D NR V+V I P GLA+DR +G
Sbjct: 1414 TVDMPRHIVVDPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGY 1473
Query: 1235 LYWNDAKILTIESSDFDGHDRRTVL--SNVPYPYGIVIVGQHIYWTDWKTKALHRADKT- 1291
+YW D + I +G + + S P PYGI + I W D K + +A K
Sbjct: 1474 VYWVDDSLDIIARIRINGENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKKIFQASKEP 1533
Query: 1292 -NASDPIVIRKNLEGLMDIRAIQSE-------RVLENACGTDNGGCSHLCLRSPLGYTCA 1343
N P VIR N+ L D+ + V N C +NGGCSHLC P +T
Sbjct: 1534 ENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFALPGLHTPK 1593
Query: 1344 CPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTI- 1402
C T K C E FLIFA S+ + L+ PE V+ T+
Sbjct: 1594 CDCAF----GTLQSDGKNCAISTENFLIFALSNSLRSLHLD-PENHSPPFQTINVERTVM 1648
Query: 1403 AVDYHWDLKMIFYTDLDLNVIRSINMTNMSE---SKTIISQKLETPNGLGVDWIANNIYW 1459
++DY I++T + + I+ +S + T+I+ + T +G+ DWI IY+
Sbjct: 1649 SLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRIYY 1708
Query: 1460 TDNEHKVIEVARLDGSSRKVLITGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQ 1519
+D +++I DGS+R V I + +PRA+ L P +GYLYW+DW H IER+ L G+
Sbjct: 1709 SDYLNQMINSMAEDGSNRTV-IARVPKPRAIVLDPCQGYLYWADWDTHAKIERATLGGNF 1767
Query: 1520 RQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQLVPDAKNPFGMTQF 1579
R IV L P+GLT+DY+E LYW DA RI+ S L G R +V A + FG+T +
Sbjct: 1768 RVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAVHAFGLTLY 1827
Query: 1580 KDYIYWTDWYKKSIIRADKRTGKNITLIRTN-LEMAMEIK-AVSADRQHGWNPCKESNGG 1637
YIYWTD Y + I RA+K G + TN L I V +Q NPC++ NGG
Sbjct: 1828 GQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNNPCEQFNGG 1887
Query: 1638 CSHLCLFRGHEYICACPDDPDHVECSTVKMLRNYRDTELKDEEFSNSTGHISFHNPNYSC 1697
CSH+C + C CP + + + K F+ S G + + C
Sbjct: 1888 CSHICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGRCI--SEEWKC 1945
Query: 1698 ATGGPGGNGPDHIE 1711
G+G D +E
Sbjct: 1946 DNDNDCGDGSDEME 1959
Score = 387 bits (953), Expect = e-106
Identities = 279/874 (31%), Positives = 393/874 (44%), Gaps = 67/874 (7%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
CI+ W+CD DNDCGD SDE NC+ +T P+ +
Sbjct: 347 CISKNWVCDTDNDCGDGSDEKNCNSTET-----------------CQPSQFNCPNHRCID 389
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWT 292
+ + K +D + N +CA D KC+ +CDG DC D +
Sbjct: 390 LSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGD------KCIGVTNRCDGVFDCSDNS 443
Query: 293 DEDSCP-MVPGSCNAGEFKC-NDGKCIPERWRCDNERDCADGGDELN-CKPNSIRNCSLD 349
DE CP PG C++ EF+C DG CIP W CD DC G DE N C P + C
Sbjct: 444 DEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVP---KTCPSS 500
Query: 350 EYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRK 409
+ C + C+ + WLCD DC + DE +C + C P CVN
Sbjct: 501 YFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPT----QPFRC-PSWQWQCLGHNICVNLS 555
Query: 410 HVCDGMKDCPRGDDEERCPLKRKCS-AEEKCEKLCITTYDGHAACACPMGFLLAEDKYSC 468
VCDG+ DCP G DE CS C C+ G A C CP+GFLLA D +C
Sbjct: 556 VVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHECVQEPFG-AKCLCPLGFLLANDSKTC 614
Query: 469 RDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLF---SNRI 525
DIDEC + CSQ C N GSFRC C TGY+L D R+CK T LL N+I
Sbjct: 615 EDIDEC--DILGSCSQHCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKI 672
Query: 526 GIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRW 585
V N S+V+ VA+D+ +FWS+ A N + V
Sbjct: 673 IADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDS 732
Query: 586 GLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHP--GDA 643
+ +A+DW+ L+WTD +EV+ +DGS R VL++ +L PR +A+ P +
Sbjct: 733 SIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEH 792
Query: 644 LVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAA 703
L+FW+DWG +P+IERA MDG R ++ D+IFWP GLTIDY +Y+ D+ ++
Sbjct: 793 LLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCD 852
Query: 704 FDGRDRRKVTTKGL--PHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVP 761
++G RR+V L HP+ALTLF+D++YWTD T+ + NK G V + P
Sbjct: 853 YNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWP 912
Query: 762 MDIHSRSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSN 821
+ I + + P + A + L L S+ P V P S L+ + +
Sbjct: 913 LGIVAVHPSKQPNSVNPCAFSRCSHLCLLSSQGP-HFYSCVCPSGWSLSPDLLNC-LRDD 970
Query: 822 SIFWTDVEKDTINRAYLN---GSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEV 878
F V + I LN S+ + + + + FD IYW + I
Sbjct: 971 QPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVE-NPGEIHR 1029
Query: 879 SKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGG--NRKKLIFG 936
K+DG+ RT+ A + P + +S + IE + G RK LI
Sbjct: 1030 VKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIAN 1089
Query: 937 QMT-----WPNGLALDLVHNRIYWTDGGNKT-----IEYANLDGTG-RTKLIENLPH--P 983
T +P G+ +D ++YW+D G + I AN+DGT +T NL H
Sbjct: 1090 DGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLEC 1149
Query: 984 FGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTL 1017
LD+ +++W I+ N D G R L
Sbjct: 1150 VTLDIEEQKLYWAVTGRGVIERGNVD-GTDRMIL 1182
Score = 371 bits (913), Expect = e-101
Identities = 189/519 (36%), Positives = 275/519 (52%), Gaps = 27/519 (5%)
Query: 263 CAEIDFECKNTK-----CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCI 317
C++ +F C N + C+P+ + CDGD DC D DE+ +C+ EF C G CI
Sbjct: 2174 CSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQ-NCTRRTCSENEFTCGYGLCI 2232
Query: 318 PERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDE 377
P+ +RCD DC D DE C + C +++TC + RC+ KT++CD DC +G DE
Sbjct: 2233 PKIFRCDRHNDCGDYSDERGCL---YQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDE 2289
Query: 378 MNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCS--A 435
+ C + TC P E N C+ +C+ + DC DE+ C + +C +
Sbjct: 2290 LMH--LCHTPEPTCPPHEFKCDNG--RCIEMMKLCNHLDDCLDNSDEKGCGIN-ECHDPS 2344
Query: 436 EEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRC 495
C+ C T C+C G+ L DK +C DIDEC E VCSQ C N +GS+ C
Sbjct: 2345 ISGCDHNCTDTLTSFY-CSCRPGYKLMSDKRTCVDIDECT-EMPFVCSQKCENVIGSYIC 2402
Query: 496 GCMTGYILRPDERSCKPTGE-SPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHY 554
C GY+ PD ++C+ P L+FSNR +R + + G Y +++GL N VALD+
Sbjct: 2403 KCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDR 2462
Query: 555 EKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEV 614
+K ++W + +VI +N N +I L +AVDW+ L+W D+ + V
Sbjct: 2463 VEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFV 2522
Query: 615 ATLDGSKRAVLV-----AND---LDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKR 666
+ L+G R +L AN+ D PR +A+HP ++W DWG I R MDG +
Sbjct: 2523 SDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNK 2582
Query: 667 KTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLF 726
+I ++ WPNG+TIDYT +YWADA IE + +G R V LPHPFA+T+F
Sbjct: 2583 SVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIF 2642
Query: 727 DDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIH 765
+D IYWTDW+T+++ NK G QT+ + P DIH
Sbjct: 2643 EDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIH 2681
Score = 315 bits (773), Expect = 1e-84
Identities = 179/513 (34%), Positives = 263/513 (51%), Gaps = 33/513 (6%)
Query: 259 ELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCP-MVPGS--CNAGEFKCNDGK 315
E+ C F+C + CV + +CDG DC D +DE CP P C A F+C +
Sbjct: 3020 EMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKNHV 3079
Query: 316 CIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGE 375
CIP W+CD + DC DG DE + S + + C + RC+ +C+GV DC +G
Sbjct: 3080 CIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDGT 3139
Query: 376 DEMNCEVSCEE-DQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPL-KRKC 433
DE E C + C E+ N +C+ +VCD DC DE C K +
Sbjct: 3140 DE--TEEHCRKPTPKPCTEYEYKCGNG--HCIPHDNVCDDADDCGDWSDELGCNKGKERT 3195
Query: 434 SAEEKCEKLCITTYDGHAACACPMGF-LLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGS 492
AE CE+ C +G C+C GF D+ SC DI+EC EQ C Q C NT GS
Sbjct: 3196 CAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINEC--EQFGTCPQHCRNTKGS 3253
Query: 493 FRCGCMTGYILRPDE--RSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVAL 550
+ C C G+ D + C G SP LL + + IR+ L+ + + ++ A+
Sbjct: 3254 YECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQDEEYIQAV 3313
Query: 551 DYHYEKK-----LVFWS----ENNLRVIRVA-----QMNTKNMSDVIRWGLE---TPAGV 593
DY ++ K +V+++ + I+ A + N+ + L+ P G+
Sbjct: 3314 DYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGI 3373
Query: 594 AVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPN 653
AVDW+ ++W+D +R+EVA LDG R L++ DLD+P AIAV+P L+FWTDWG
Sbjct: 3374 AVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKE 3433
Query: 654 PKIERADMDGDKRKTVIYDEIFWPNGLTIDY-TESKIYWADAKHHVIERAAFDGRDRRKV 712
PKIE A M+G+ R ++++++ WP GL+IDY +IYW+D K VIE +DG DRR V
Sbjct: 3434 PKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRR-V 3492
Query: 713 TTKGLPHPFALTLFDDAIYWTDWHTKSISTVNK 745
K +P++L +F+D +YW + NK
Sbjct: 3493 IAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNK 3525
Score = 242 bits (593), Expect = 7e-63
Identities = 126/335 (37%), Positives = 183/335 (54%), Gaps = 18/335 (5%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPI--NYLIFAHRVDIRVISLDVPYLIDV 1083
CS C G C C G DGKTC YLIF++R +R +++D Y +
Sbjct: 2389 CSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTID-GYFYSL 2447
Query: 1084 VLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDS 1143
+L L N + +D D +YW DT ++ I+R T+ ET+I + L A+ + +D
Sbjct: 2448 ILE--GLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDW 2505
Query: 1144 TGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDS--------PRAIALHYEYGYMFWSD 1195
RK+YW D + + V++L+G +R++L +D+ PR +ALH +YGY++W+D
Sbjct: 2506 VSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWAD 2565
Query: 1196 WGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDR 1255
WG A I R MDG N+ VI+ K++WPNG+ ID LYW DA + IE SD +GH R
Sbjct: 2566 WGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHR 2625
Query: 1256 RTVLSN-VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQS 1314
TV +P+P+ I I IYWTDW T+ + + +K + S+ + DI
Sbjct: 2626 HTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHP 2685
Query: 1315 ER--VLENACGTDNGGCSHLCLRSP--LGYTCACP 1345
R ++ N CGT+NGGCSHLCL P G+TC CP
Sbjct: 2686 YRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECP 2720
Score = 205 bits (501), Expect = 1e-51
Identities = 115/341 (33%), Positives = 177/341 (51%), Gaps = 20/341 (5%)
Query: 1329 CSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQ 1388
CS C Y C C G + + +T ++ S+ E +LIF+ R + ++++
Sbjct: 2389 CSQKCENVIGSYICKCAPG--YLREPDGKTCRQ-NSNIEPYLIFSNRYYLRNLTIDG--- 2442
Query: 1389 WDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGL 1448
+ +L ++ + N +A+D+ K +++ D VI + + N + +TII+ +L L
Sbjct: 2443 YFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFL-NKTNKETIINHRLPAAESL 2501
Query: 1449 GVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITGLTE---------PRALALFPAKGYL 1499
VDW++ +YW D + V+ L+G R++L + PR LAL P GYL
Sbjct: 2502 AVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYL 2561
Query: 1500 YWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLN 1559
YW+DWG YI R +DG+ + +I+ L +PNG+TIDY LYW DA I+ SDL
Sbjct: 2562 YWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLE 2621
Query: 1560 GQHRVQLVPDA-KNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIK 1618
G HR + A +PF +T F+D IYWTDW +++ + +K G N + +I
Sbjct: 2622 GHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIH 2681
Query: 1619 AVSADRQH-GWNPCKESNGGCSHLCLFR--GHEYICACPDD 1656
RQ NPC +NGGCSHLCL + G + C CPDD
Sbjct: 2682 VYHPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPDD 2722
Score = 200 bits (488), Expect = 4e-50
Identities = 98/281 (34%), Positives = 157/281 (55%), Gaps = 34/281 (12%)
Query: 796 IDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPA 855
ID + +E + + VALD+D+ ++W D ++ I R +LN +++ TI++ L
Sbjct: 2440 IDGYFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAE 2499
Query: 856 GLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHID--------KPRDIVVNPEGG 907
LA DW++ K+YW D + + VS +G R +LA +D PR + ++P+ G
Sbjct: 2500 SLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYG 2559
Query: 908 VMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYAN 967
+YW+DWG I R MDG N+ +I ++ WPNG+ +D ++ +YW D IEY++
Sbjct: 2560 YLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSD 2619
Query: 968 LDGTGRTKLIEN-LPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTL--------- 1017
L+G R + + LPHPF + ++ D ++WTDW+T++++ NK G+ R+TL
Sbjct: 2620 LEGHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFD 2679
Query: 1018 --------------GCGKNNGGCSHLCLLKPGGR--SCACP 1042
CG NNGGCSHLCL+KPGG+ +C CP
Sbjct: 2680 IHVYHPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECP 2720
Score = 183 bits (446), Expect = 4e-45
Identities = 118/361 (32%), Positives = 181/361 (50%), Gaps = 30/361 (8%)
Query: 1327 GGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEE-FLIFATRGSITYISLES 1385
G C C + Y C C G S +D+ K+C + L+ I +L S
Sbjct: 3241 GTCPQHCRNTKGSYECVCADGFT---SMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSS 3297
Query: 1386 PEQWDVTLPVKEVKNTIAVDYHWD-----LKMIFYT----DLDLNVIRSINMTNMSESKT 1436
E++ L +E AVDY WD L +++YT I+ + N +
Sbjct: 3298 -ERFSEYLQDEEYIQ--AVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRN 3354
Query: 1437 IISQKLET-------PNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLI-TGLTEPR 1488
+ Q+++ P+G+ VDW+ +IYW+D ++K IEVA+LDG RK LI T L +P
Sbjct: 3355 NLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPA 3414
Query: 1489 ALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDY-KERRLYWTD 1547
A+A+ P G ++W+DWG+ P IE ++++G R I+V DLG+P GL+IDY R+YW+D
Sbjct: 3415 AIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSD 3474
Query: 1548 ALKDRIDTSDLNGQHRVQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADK--RTGKNIT 1605
+D I+T +G R + +A NP+ + F+D +YW K + + +K + K T
Sbjct: 3475 FKEDVIETIKYDGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKT 3534
Query: 1606 LIRTNLEMAMEIKAVSADRQHGWNPCKESNGGCSHLCLFRGHEYICACPDDPDHVECSTV 1665
L+ + I + N CK+ CSHLCL R Y CACP +E ST
Sbjct: 3535 LVVNPWLTQVRIFHQLRYNKSVPNLCKQI---CSHLCLLRPGGYSCACPQGSSFIEGSTT 3591
Query: 1666 K 1666
+
Sbjct: 3592 E 3592
Score = 180 bits (439), Expect = 3e-44
Identities = 143/504 (28%), Positives = 223/504 (44%), Gaps = 54/504 (10%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPG-SCNAGEFKC-----NDGKC 316
C +F+C +C+P ++ CDGDNDCGD +DED +C+ EF C D +C
Sbjct: 2132 CLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRC 2191
Query: 317 IPERWRCDNERDCADGGDE-LNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGE 375
IP+ W CD + DC DG DE NC + R CS +E+TC C+ K + CD DC +
Sbjct: 2192 IPQSWVCDGDVDCTDGYDENQNC---TRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYS 2248
Query: 376 DEMNC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE--ERCPL-KR 431
DE C +C+++Q+TC+ N C+++ VCD DC G DE C +
Sbjct: 2249 DERGCLYQTCQQNQFTCQ-------NG--RCISKTFVCDEDNDCGDGSDELMHLCHTPEP 2299
Query: 432 KCSAEE-KCEK-LCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNT 489
C E KC+ CI + C L D+ C I+EC C C++T
Sbjct: 2300 TCPPHEFKCDNGRCI---EMMKLCNHLDDCLDNSDEKGC-GINECHDPSISGCDHNCTDT 2355
Query: 490 VGSFRCGCMTGYILRPDERSCKPTGESPTLLF------SNRIGIRQVWLTGDNYMSVVKG 543
+ SF C C GY L D+R+C E + F N IG + Y+ G
Sbjct: 2356 LTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIG-SYICKCAPGYLREPDG 2414
Query: 544 LHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLF 603
+ + E L+F + LR + + +I GL+ + D + L+
Sbjct: 2415 --KTCRQNSNIEPYLIFSNRYYLRNLTI----DGYFYSLILEGLDNVVALDFDRVEKRLY 2468
Query: 604 WTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDG 663
W D+ + +E L+ + + ++ + L ++AV ++W D + +D++G
Sbjct: 2469 WIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLD-ARLDGLFVSDLNG 2527
Query: 664 DKRK-----TVIYDEIFW---PNGLTIDYTESKIYWADAKHHV-IERAAFDGRDRRKVTT 714
R+ V + F P GL + +YWAD H I R DG ++ + +
Sbjct: 2528 GHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIIS 2587
Query: 715 KGLPHPFALTL--FDDAIYWTDWH 736
L P +T+ +D +YW D H
Sbjct: 2588 TKLEWPNGITIDYTNDLLYWADAH 2611
Score = 172 bits (419), Expect = 8e-42
Identities = 121/357 (33%), Positives = 171/357 (47%), Gaps = 29/357 (8%)
Query: 1024 GGCSHLCLLKPGGRSCACPIGIKLNKD--GKTCA-DGPINYLIFAHRVDIRVISLDVPYL 1080
G C C G C C G D GK CA +G L+ V IR +L
Sbjct: 3241 GTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERF 3300
Query: 1081 IDVVLPLPPLKNALGVDVD-HSTGL--IYWTDTGQRK----IQRA---------TRLGTH 1124
+ + ++ A+ D D GL +Y+T G+ I+RA L
Sbjct: 3301 SEYLQDEEYIQ-AVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQE 3359
Query: 1125 VETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIAL 1184
V+ + + DGI +D GR IYW+D IEVA+LDGR RK L+ T LD P AIA+
Sbjct: 3360 VDLKLKYVMQP-DGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAV 3418
Query: 1185 HYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEG-RLYWNDAKIL 1243
+ + G MFW+DWG KIE A M+G +R ++V + WP GL+ID + R+YW+D K
Sbjct: 3419 NPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKED 3478
Query: 1244 TIESSDFDGHDRRTVLSNVPYPYGIVIVGQHIYWTDWKTKALHRADK---TNASDPIVIR 1300
IE+ +DG DRR + PY + I +YW + + + +K +V+
Sbjct: 3479 VIETIKYDGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVN 3538
Query: 1301 KNLEGLMDIRAIQSERVLENACGTDNGGCSHLCLRSPLGYTCACPTGMPF-EKSTTD 1356
L + ++ + + N C CSHLCL P GY+CACP G F E STT+
Sbjct: 3539 PWLTQVRIFHQLRYNKSVPNLC---KQICSHLCLLRPGGYSCACPQGSSFIEGSTTE 3592
Score = 169 bits (412), Expect = 6e-41
Identities = 79/224 (35%), Positives = 127/224 (56%), Gaps = 6/224 (2%)
Query: 1437 IISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITGLTEPRALALFPAK 1496
+ + ++E L DWI+ N+YWTD+ +K I V RL +R+ ++ L PR++ + P
Sbjct: 4 LAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVVQYLNNPRSVVVHPFA 63
Query: 1497 GYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTS 1556
GYL+++DW I R++ DGS ++ LG+PNGL ID+ RLYW DA D+I+ S
Sbjct: 64 GYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHS 123
Query: 1557 DLNGQHRVQL--VPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMA 1614
+G R +L + +PFG+ F +++++TDW +IIR K G +T+IR+ +
Sbjct: 124 TFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYI 183
Query: 1615 MEIKAVSADRQHGWNPCKE---SNGGCSHLCL-FRGHEYICACP 1654
+ +K+ + Q G N C + NG CSH C + +C CP
Sbjct: 184 LHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCP 227
Score = 167 bits (407), Expect = 2e-40
Identities = 82/227 (36%), Positives = 116/227 (51%), Gaps = 20/227 (8%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
+C F CKN +CVP + CDG +DC D +DE C + +C++ F C G+CIP W
Sbjct: 251 QCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHW 310
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCE 381
RCD DC DG DE NC ++ +C +YTC + +C+ K W+CD DC +G DE NC
Sbjct: 311 RCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCN 370
Query: 382 VSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPL-----KRKCSAE 436
S E TC+P + N C++ VCDG KDC G DE C L + KC++
Sbjct: 371 -STE----TCQPSQFNCPN--HRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASG 423
Query: 437 EKC---EKLCITTYD-----GHAACACPMGFLLAEDKYSCRDIDECM 475
+KC C +D A C + D++ C++ C+
Sbjct: 424 DKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICI 470
Score = 160 bits (389), Expect = 4e-38
Identities = 87/228 (38%), Positives = 121/228 (53%), Gaps = 22/228 (9%)
Query: 854 PAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSD 913
P G+A DW+ IYW+D RIEV+K DG R L +D+P I VNP+ G+M+W+D
Sbjct: 3370 PDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTD 3429
Query: 914 WGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHN-RIYWTDGGNKTIEYANLDGTG 972
WG P IE A M+G +R L+F + WP GL++D ++N RIYW+D IE DGT
Sbjct: 3430 WGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTD 3489
Query: 973 RTKLIENLPHPFGLDLYGDEVFWTDWDTQSIQAANK-DTGAKRRTLGCG----------- 1020
R + + +P+ LD++ D+++W + + NK G K +TL
Sbjct: 3490 RRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFHQ 3549
Query: 1021 -KNNGG--------CSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPI 1059
+ N CSHLCLL+PGG SCACP G + T D I
Sbjct: 3550 LRYNKSVPNLCKQICSHLCLLRPGGYSCACPQGSSFIEGSTTECDAAI 3597
Score = 159 bits (387), Expect = 6e-38
Identities = 81/230 (35%), Positives = 126/230 (54%), Gaps = 8/230 (3%)
Query: 1126 ETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALH 1185
E + N + + + D + +YWTD SI V L + R+ +V L++PR++ +H
Sbjct: 2 EILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVVQY-LNNPRSVVVH 60
Query: 1186 YEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTI 1245
GY+F++DW AKI RA DG++ +++ + WPNGLAID RLYW DA I
Sbjct: 61 PFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKI 120
Query: 1246 ESSDFDGHDRRTV--LSNVPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNL 1303
E S FDG DRR + + + +P+G+ I G+H+++TDW+ A+ R K + + VIR +
Sbjct: 121 EHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGI 180
Query: 1304 EGLMDIRAIQ-SERVLENACGT---DNGGCSHLCLRSP-LGYTCACPTGM 1348
++ +++ + + NAC NG CSH C P C CP GM
Sbjct: 181 AYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGM 230
Score = 152 bits (368), Expect = 1e-35
Identities = 138/518 (26%), Positives = 214/518 (41%), Gaps = 56/518 (10%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C E +F C N +C+P + CD NDCGD +DE C M +C+ F+C G C+ +
Sbjct: 2985 CTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEM--RTCHPEYFQCTSGHCVHSELK 3042
Query: 323 CDNERDCADGGDELNCKPNSIRN---CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMN 379
CD DC D DE +C P + C + C + C+ W CDG DC +G DE
Sbjct: 3043 CDGSADCLDASDEADC-PTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDE-- 3099
Query: 380 CEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDD--EERC--PLKRKCSA 435
E+ D P N C+ VC+G+ DC G D EE C P + C+
Sbjct: 3100 -ELHLCLDVPCNSPNRFRCDN--NRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTE 3156
Query: 436 -EEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSN-TVGSF 493
E KC +D A G D+ C E ++ +C Q C+ G F
Sbjct: 3157 YEYKCGNGHCIPHDNVCDDADDCGDW--SDELGCNKGKERTCAEN-ICEQNCTQLNEGGF 3213
Query: 494 RCGCMTGYILRPDERS-------CKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHN 546
C C G+ +R+ C+ G P + + V G MS G
Sbjct: 3214 ICSCTAGFETNVFDRTSCLDINECEQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRC 3273
Query: 547 AVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIH-----DL 601
A + +N+R IR ++++ S+ ++ E V DW +
Sbjct: 3274 AAE-----GSSPLLLLPDNVR-IRKYNLSSERFSEYLQ-DEEYIQAVDYDWDPKDIGLSV 3326
Query: 602 LFWTDSG-------TRRVEVATLDGSKRAVLVANDLD-----KPRAIAVHPGDALVFWTD 649
+++T G +R + + + ++ DL +P IAV ++W+D
Sbjct: 3327 VYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSD 3386
Query: 650 WGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWAD-AKHHVIERAAFDGRD 708
N +IE A +DG RK +I ++ P + ++ ++W D K IE A +G D
Sbjct: 3387 -VKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGED 3445
Query: 709 RRKVTTKGLPHPFALT---LFDDAIYWTDWHTKSISTV 743
R + + L P L+ L +D IYW+D+ I T+
Sbjct: 3446 RNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETI 3483
Score = 150 bits (364), Expect = 4e-35
Identities = 89/269 (33%), Positives = 122/269 (45%), Gaps = 28/269 (10%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
C+ + CD NDCGD SDE C L NA+ +
Sbjct: 1979 CVQYSYRCDYYNDCGDGSDEAGC-------LFRDCNATTEF------------MCNNRRC 2019
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTK-CVPKDFQCDGDNDCGDW 291
I E C +DN + ++ + C +C N+ C+P+ + CDGDNDCGD
Sbjct: 2020 IPREFIC--NGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDN 2077
Query: 292 TDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEY 351
+DE+ +C++ EF+C G+CIP+ W CD E DC D DE +S R C DE+
Sbjct: 2078 SDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEF 2137
Query: 352 TCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSN---AFRNCVNR 408
C RC+ W+CDG DC + DE + C+ C E L N R C+ +
Sbjct: 2138 KCDGGRCIPSEWICDGDNDCGDMSDE-DKRHQCQNQ--NCSDSEFLCVNDRPPDRRCIPQ 2194
Query: 409 KHVCDGMKDCPRGDDEERCPLKRKCSAEE 437
VCDG DC G DE + +R CS E
Sbjct: 2195 SWVCDGDVDCTDGYDENQNCTRRTCSENE 2223
Score = 147 bits (357), Expect = 3e-34
Identities = 87/254 (34%), Positives = 120/254 (47%), Gaps = 27/254 (10%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
CI W CD DNDCGD SDE + +S ++ D N T T +
Sbjct: 2873 CIPQAWKCDVDNDCGDHSDEP----------IEECMSSAHLCD---NFTEFSCKTNYRCI 2919
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEI-DFECKNTKCVPKDFQCDGDNDCGDW 291
++ + C +D+ + ++ Q E C + DF CKN C+P +QCDG NDCGD
Sbjct: 2920 PKW-AVC--NGVDDCRD--NSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDN 2974
Query: 292 TDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEY 351
+DE++C P C EF+C + +CIP RW CD+ DC D DE +C+ +R C + +
Sbjct: 2975 SDEENC--APRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCE---MRTCHPEYF 3029
Query: 352 TCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHV 411
C CV CDG DC + DE +C + Y C+ N C+
Sbjct: 3030 QCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGAY-CQATMFECKN--HVCIPPYWK 3086
Query: 412 CDGMKDCPRGDDEE 425
CDG DC G DEE
Sbjct: 3087 CDGDDDCGDGSDEE 3100
Score = 147 bits (355), Expect = 5e-34
Identities = 116/474 (24%), Positives = 212/474 (44%), Gaps = 34/474 (7%)
Query: 255 NQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDG 314
NQ C+E +F C C+PK F+CD NDCGD++DE C + +C +F C +G
Sbjct: 2211 NQNCTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGC--LYQTCQQNQFTCQNG 2268
Query: 315 KCIPERWRCDNERDCADGGDEL-NCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTN 373
+CI + + CD + DC DG DEL + C E+ C + RC+ LC+ + DC +
Sbjct: 2269 RCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLD 2328
Query: 374 GEDEMNCEVS-CEEDQYT-CRPQ-EHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLK 430
DE C ++ C + + C +++ + +C + + C D +E +
Sbjct: 2329 NSDEKGCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCV--DIDECTEMP 2386
Query: 431 RKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCR---DIDECMYEQDPVCSQTCS 487
CS +KCE + G C C G+L D +CR +I+ + + +
Sbjct: 2387 FVCS--QKCENVI-----GSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNL- 2438
Query: 488 NTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVK-GLHN 546
T+ + + + + + + R I +++L N +++ L
Sbjct: 2439 -TIDGYFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPA 2497
Query: 547 AVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIR--------WGLETPAGVAVDWI 598
A +L + + ++W + L + V+ +N + + + + + P G+A+
Sbjct: 2498 AESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQ 2557
Query: 599 HDLLFWTDSGTRR-VEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIE 657
+ L+W D G R + +DG+ ++V+++ L+ P I + + L++W D IE
Sbjct: 2558 YGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWAD-AHLGYIE 2616
Query: 658 RADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERA-AFDGRDRR 710
+D++G R TV YD P+ I E IYW D +E+ +DG +R+
Sbjct: 2617 YSDLEGHHRHTV-YDGAL-PHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQ 2668
Score = 136 bits (330), Expect = 5e-31
Identities = 79/233 (33%), Positives = 116/233 (49%), Gaps = 31/233 (13%)
Query: 857 LAFDWITDKIYWTDGGTNRIEVSK-SDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWG 915
LAFDWI+ +YWTD I V + +D + RT++ +++ PR +VV+P G ++++DW
Sbjct: 15 LAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV--QYLNNPRSVVVHPFAGYLFFTDWF 72
Query: 916 ASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTK 975
I RA DG + +I + WPNGLA+D +R+YW D IE++ DG R +
Sbjct: 73 RPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRR 132
Query: 976 L--IENLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTLGCG------------- 1020
L IE + HPFGL ++G+ +F+TDW +I K G + + G
Sbjct: 133 LGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVN 192
Query: 1021 ------------KNNGGCSHLCLLKPG-GRSCACPIGIKLNKDGKTCADGPIN 1060
NG CSH C P R C CP G++L + TC P N
Sbjct: 193 IQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEGDPTN 245
Score = 136 bits (329), Expect = 7e-31
Identities = 64/186 (34%), Positives = 98/186 (52%), Gaps = 11/186 (5%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C +++C N +C+P+ +QCD NDC D +DEDS +C G+F+C +G+CIP+ W+
Sbjct: 2820 CDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWK 2879
Query: 323 CDNERDCADGGDE--LNCKPNSIRNCSLDEYTC-ADRRCVLKTWLCDGVRDCTNGEDEMN 379
CD + DC D DE C ++ + E++C + RC+ K +C+GV DC + DE
Sbjct: 2880 CDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQG 2939
Query: 380 CEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKC 439
CE + TC P +C+ + CDG DC DEE C + +E +C
Sbjct: 2940 CE------ERTCHPVGDFRCKN-HHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRC 2992
Query: 440 -EKLCI 444
+ CI
Sbjct: 2993 VNQQCI 2998
Score = 131 bits (317), Expect = 2e-29
Identities = 101/334 (30%), Positives = 144/334 (43%), Gaps = 46/334 (13%)
Query: 169 STNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTK 228
S CI+ EW CD DNDCGD SDE+ V P+A N G + +
Sbjct: 1934 SNGRCISEEWKCDNDNDCGDGSDEME-SVCALHTCSPTAFTCAN-GRCV----------Q 1981
Query: 229 PTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDC 288
+ Y + C + D A N E M C N +C+P++F C+G ++C
Sbjct: 1982 YSYRCDYYNDCGDGS-DEAGCLFRDCNATTEFM--------CNNRRCIPREFICNGVDNC 2032
Query: 289 GD--WTDEDSCPMVPGSCNAGEFKC-NDGKCIPERWRCDNERDCADGGDELNCKPNSIRN 345
D +DE +CP +C +G KC N CIP + CD + DC D DE N +
Sbjct: 2033 HDNNTSDEKNCP--DRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDE-NPTYCTTHT 2089
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNC 405
CS E+ CA RC+ + W CD DC + DE SC + TC E C
Sbjct: 2090 CSSSEFQCASGRCIPQHWYCDQETDCFDASDE---PASCGHSERTCLADEFKCDGG--RC 2144
Query: 406 VNRKHVCDGMKDCPRGDDEERCPLKRKCSAE--EKCEKLCITTYDGHAACACPMGFLLAE 463
+ + +CDG DC DE++ + +C + E LC+ C P ++
Sbjct: 2145 IPSEWICDGDNDCGDMSDEDK---RHQCQNQNCSDSEFLCVNDRPPDRRC-IPQSWVCDG 2200
Query: 464 DKYSCRDIDECMYEQDPVCS-QTCSNTVGSFRCG 496
D C D Y+++ C+ +TCS F CG
Sbjct: 2201 D-VDCTD----GYDENQNCTRRTCSE--NEFTCG 2227
Score = 130 bits (313), Expect = 6e-29
Identities = 65/173 (37%), Positives = 95/173 (54%), Gaps = 2/173 (1%)
Query: 587 LETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVF 646
+E +A DWI L+WTDS + + V L R +V L+ PR++ VHP +F
Sbjct: 9 VENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVVQY-LNNPRSVVVHPFAGYLF 67
Query: 647 WTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDG 706
+TDW KI RA DG VI + WPNGL ID+ S++YW DA IE + FDG
Sbjct: 68 FTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDG 127
Query: 707 RDRRKV-TTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGL 758
DRR++ + + HPF L +F + +++TDW +I V K G + + +G+
Sbjct: 128 LDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGI 180
Score = 126 bits (303), Expect = 1e-27
Identities = 64/184 (34%), Positives = 95/184 (51%), Gaps = 17/184 (9%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
RC F C N +C+ ++++CD DNDCGD +DE +C+ F C +G+C+ +
Sbjct: 1925 RCGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSY 1984
Query: 322 RCDNERDCADGGDELNCKPNSIRNC-SLDEYTCADRRCVLKTWLCDGVRDC--TNGEDEM 378
RCD DC DG DE C R+C + E+ C +RRC+ + ++C+GV +C N DE
Sbjct: 1985 RCDYYNDCGDGSDEAGC---LFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEK 2041
Query: 379 NC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEE--RCPLKRKCSA 435
NC + +C+ C SN C+ R ++CDG DC DE C S+
Sbjct: 2042 NCPDRTCQSGYTKCH-----NSNI---CIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSS 2093
Query: 436 EEKC 439
E +C
Sbjct: 2094 EFQC 2097
Score = 108 bits (259), Expect = 2e-22
Identities = 52/171 (30%), Positives = 79/171 (46%), Gaps = 4/171 (2%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C F+C + C C+ +C D +DED C++ E++C + +CIPE W+
Sbjct: 2779 CRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQ 2838
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV 382
CD DC D DE + + R C ++ CA+ RC+ + W CD DC + DE E
Sbjct: 2839 CDTFNDCEDNSDE-DSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEE- 2896
Query: 383 SCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKC 433
C + C C+ + VC+G+ DC DE+ C +R C
Sbjct: 2897 -CMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCE-ERTC 2945
Score = 103 bits (247), Expect = 6e-21
Identities = 86/301 (28%), Positives = 119/301 (39%), Gaps = 47/301 (15%)
Query: 166 ICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIA 225
+C + CI + W CDG DC D SDE+ + L + G+ + T+ A
Sbjct: 2744 LCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRL---GQFQCSDGNCTSPQTLCNA 2800
Query: 226 LTK-PTVVIRYESFCAKKALDN----AANPR---STWNQPVELMRCAEIDFE----CKNT 273
P C D+ AN R +W Q C + E C +
Sbjct: 2801 HQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESW-QCDTFNDCEDNSDEDSSHCASR 2859
Query: 274 KCVPKDFQC------------DGDNDCGDWTDE--DSCPMVPGSC-NAGEFKCNDG-KCI 317
C P F+C D DNDCGD +DE + C C N EF C +CI
Sbjct: 2860 TCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCI 2919
Query: 318 PERWRCDNERDCADGGDELNCKPNSIRNC-SLDEYTCADRRCVLKTWLCDGVRDCTNGED 376
P+ C+ DC D DE C+ R C + ++ C + C+ W CDG DC + D
Sbjct: 2920 PKWAVCNGVDDCRDNSDEQGCEE---RTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSD 2976
Query: 377 EMNCEV-SCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSA 435
E NC C E ++ C Q+ C+ + +CD DC DE C + R C
Sbjct: 2977 EENCAPRECTESEFRCVNQQ---------CIPSRWICDHYNDCGDNSDERDCEM-RTCHP 3026
Query: 436 E 436
E
Sbjct: 3027 E 3027
Score = 90.2 bits (214), Expect = 6e-17
Identities = 73/277 (26%), Positives = 113/277 (40%), Gaps = 44/277 (15%)
Query: 254 WNQPVELMRCAEIDFECKNTKCVP---KDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFK 310
+ QP+ C + C + + K F C+ +D S +P C++ +F
Sbjct: 2686 YRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMP-MCSSTQFL 2744
Query: 311 C-NDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVR 369
C N+ KCIP W+CD ++DC+DG DEL P R C L ++ C+D C LC+ +
Sbjct: 2745 CANNEKCIPIWWKCDGQKDCSDGSDELALCPQ--RFCRLGQFQCSDGNCTSPQTLCNAHQ 2802
Query: 370 DCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEE---- 425
+C +G DE + CE + C E +N + C+ CD DC DE+
Sbjct: 2803 NCPDGSDE--DRLLCE--NHHCDSNEWQCAN--KRCIPESWQCDTFNDCEDNSDEDSSHC 2856
Query: 426 ----------RC------PLKRKCSAEEKC-----EKL--CITT---YDGHAACACPMGF 459
RC P KC + C E + C+++ D +C +
Sbjct: 2857 ASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNY 2916
Query: 460 LLAEDKYSCRDIDECMYEQDPV-CSQTCSNTVGSFRC 495
C +D+C D C + + VG FRC
Sbjct: 2917 RCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRC 2953
Score = 68.5 bits (160), Expect = 2e-10
Identities = 37/114 (32%), Positives = 54/114 (47%), Gaps = 7/114 (6%)
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCE 381
+C +E + + +C ++ C +TC++ RC+ + W CD DC +G DEM E
Sbjct: 1902 QCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGRCISEEWKCDNDNDCGDGSDEM--E 1959
Query: 382 VSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSA 435
C +TC P +N CV + CD DC G DE C L R C+A
Sbjct: 1960 SVCA--LHTCSPTAFTCANG--RCVQYSYRCDYYNDCGDGSDEAGC-LFRDCNA 2008
Score = 67.3 bits (157), Expect = 5e-10
Identities = 44/180 (24%), Positives = 86/180 (47%), Gaps = 8/180 (4%)
Query: 796 IDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPA 855
+ +D+ + +A+DW I+W+DV+ I A L+G ++ ++ ++L PA
Sbjct: 3357 VQEVDLKLKYVMQPDGIAVDW--VGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPA 3414
Query: 856 GLAFDWITDKIYWTDGGTN-RIEVSKSDGSMRTLLAWDHIDKPRDIVVN-PEGGVMYWSD 913
+A + ++WTD G +IE + +G R +L ++ + P + ++ +YWSD
Sbjct: 3415 AIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSD 3474
Query: 914 WGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGR 973
+ IE DG +R+ + M N +LD+ +++YW + N G G+
Sbjct: 3475 F-KEDVIETIKYDGTDRRVIAKEAM---NPYSLDIFEDQLYWISKEKGEVWKQNKFGQGK 3530
Score = 66.9 bits (156), Expect = 6e-10
Identities = 40/157 (25%), Positives = 82/157 (52%), Gaps = 6/157 (3%)
Query: 559 VFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTR-RVEVATL 617
++WS+ + I VA+++ + +I L+ PA +AV+ L+FWTD G ++E A +
Sbjct: 3382 IYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWM 3441
Query: 618 DGSKRAVLVANDLDKPRAIAV-HPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFW 676
+G R +LV DL P +++ + + ++W+D+ IE DG R+ + + +
Sbjct: 3442 NGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDF-KEDVIETIKYDGTDRRVIAKEAM-- 3498
Query: 677 PNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVT 713
N ++D E ++YW + + + G+ +++ T
Sbjct: 3499 -NPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKT 3534
Score = 62.9 bits (146), Expect = 1e-08
Identities = 35/108 (32%), Positives = 56/108 (51%), Gaps = 4/108 (3%)
Query: 823 IFWTDVEKDT-INRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKS 881
+F+TD + I RA+ +GSH ++++ L WP GLA DW ++YW D ++IE S
Sbjct: 66 LFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTF 125
Query: 882 DGSMRTLLAW-DHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGG 928
DG R L + + P + + G ++++DW I DGG
Sbjct: 126 DGLDRRRLGHIEQMTHPFGLAI--FGEHLFFTDWRLGAIIRVRKADGG 171
Score = 55.6 bits (128), Expect = 2e-06
Identities = 40/128 (31%), Positives = 61/128 (47%), Gaps = 4/128 (3%)
Query: 1090 LKNALGVDVDHSTGLIYWTDTGQ-RKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKI 1148
L N V V G +++TD + KI RA G+H+ VI L +G+ ID ++
Sbjct: 51 LNNPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRL 110
Query: 1149 YWTDGGRNSIEVAELDGRNRKVLVW-TGLDSPRAIALHYEYGYMFWSDWGTSAKIERADM 1207
YW D + IE + DG +R+ L + P +A+ E ++F++DW A I
Sbjct: 111 YWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGE--HLFFTDWRLGAIIRVRKA 168
Query: 1208 DGNNRRVI 1215
DG VI
Sbjct: 169 DGGEMTVI 176
Score = 46.8 bits (106), Expect = 7e-04
Identities = 59/234 (25%), Positives = 82/234 (35%), Gaps = 31/234 (13%)
Query: 91 KAIDVIHTDPDDGPLNEGTEDDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXX 150
+ ID+ D +G+ D+ GC+ C F C CI + R
Sbjct: 386 RCIDLSFVCDGDKDCVDGS-DEVGCVLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSD 444
Query: 151 XXXXXRSCDE--HENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSAN 208
H + C +CI W CDG DC SDE N V KT PS+
Sbjct: 445 EAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKT---CPSSY 501
Query: 209 ASLNIGDVITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQ-PVELMRCAEID 267
+ G+ I + C + DN S P + RC
Sbjct: 502 FHCDNGNCIHRAWL----------------CDR---DNDCGDMSDEKDCPTQPFRCPSWQ 542
Query: 268 FEC-KNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPG-SCNAGEFKCNDGKCIPE 319
++C + CV CDG DC + TDE P+ G SC+ C +C+ E
Sbjct: 543 WQCLGHNICVNLSVVCDGIFDCPNGTDES--PLCNGNSCSDFNGGCTH-ECVQE 593
Score = 46.0 bits (104), Expect = 0.001
Identities = 32/99 (32%), Positives = 40/99 (40%), Gaps = 9/99 (9%)
Query: 99 DPDDGPLNEGTEDDAGCIT-PCLKINFSCQISCTCIPM----EKRXXXXXXXXXXXXXXX 153
D D+ + E+ C T C F C S CIP ++
Sbjct: 2069 DGDNDCGDNSDENPTYCTTHTCSSSEFQCA-SGRCIPQHWYCDQETDCFDASDEPASCGH 2127
Query: 154 XXRSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDE 192
R+C E + C CI EW+CDGDNDCGD SDE
Sbjct: 2128 SERTCLADEFK--CDGGR-CIPSEWICDGDNDCGDMSDE 2163
Score = 45.6 bits (103), Expect = 0.002
Identities = 35/127 (27%), Positives = 67/127 (52%), Gaps = 8/127 (6%)
Query: 539 SVVKGLHNAVALDYHYEKKLVFWSE--NNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVD 596
+VV+ L+N ++ H +F+++ +++R A + ++ VI L P G+A+D
Sbjct: 46 TVVQYLNNPRSVVVHPFAGYLFFTDWFRPAKIMR-AWSDGSHLLPVINTTLGWPNGLAID 104
Query: 597 WIHDLLFWTDSGTRRVEVATLDG-SKRAVLVANDLDKPRAIAVHPGDALVFWTDW--GPN 653
W L+W D+ ++E +T DG +R + + P +A+ G+ L F+TDW G
Sbjct: 105 WAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIF-GEHL-FFTDWRLGAI 162
Query: 654 PKIERAD 660
++ +AD
Sbjct: 163 IRVRKAD 169
Score = 43.2 bits (97), Expect = 0.009
Identities = 19/42 (45%), Positives = 24/42 (57%), Gaps = 3/42 (7%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDV 197
R C E E R + CI W+CD NDCGD SDE +C++
Sbjct: 2983 RECTESEFRCV---NQQCIPSRWICDHYNDCGDNSDERDCEM 3021
Score = 40.7 bits (91), Expect = 0.046
Identities = 20/71 (28%), Positives = 35/71 (49%), Gaps = 2/71 (2%)
Query: 1212 RRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLSNVPYPYGIVI- 1270
R ++ N+++ LA D I LYW D+ +I RRTV+ + P +V+
Sbjct: 1 REILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVVQYLNNPRSVVVH 60
Query: 1271 -VGQHIYWTDW 1280
++++TDW
Sbjct: 61 PFAGYLFFTDW 71
Score = 39.5 bits (88), Expect = 0.11
Identities = 26/95 (27%), Positives = 44/95 (46%), Gaps = 3/95 (3%)
Query: 1520 RQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQLVPDAKNPFGMT-- 1577
R+I+ + L D+ + LYWTD+ I L + R +V NP +
Sbjct: 1 REILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVVQYLNNPRSVVVH 60
Query: 1578 QFKDYIYWTDWYKKS-IIRADKRTGKNITLIRTNL 1611
F Y+++TDW++ + I+RA + +I T L
Sbjct: 61 PFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTL 95
Score = 39.5 bits (88), Expect = 0.11
Identities = 15/22 (68%), Positives = 17/22 (77%)
Query: 171 NVCIALEWLCDGDNDCGDFSDE 192
+VCI W CDGD+DCGD SDE
Sbjct: 3078 HVCIPPYWKCDGDDDCGDGSDE 3099
Score = 37.5 bits (83), Expect = 0.43
Identities = 29/110 (26%), Positives = 46/110 (41%), Gaps = 6/110 (5%)
Query: 86 RPSLQKAIDVIHTDPDDGPLNEGTEDDAGCIT-PCLKINFSCQISCTCIPMEKRXXXXXX 144
RP ++ I D +G +++ C C + F+C CIP R
Sbjct: 2185 RPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGL-CIPKIFRCDRHND 2243
Query: 145 XXXXXXXXX-XXRSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEI 193
++C + N+ C + CI+ ++CD DNDCGD SDE+
Sbjct: 2244 CGDYSDERGCLYQTCQQ--NQFTCQNGR-CISKTFVCDEDNDCGDGSDEL 2290
Score = 37.1 bits (82), Expect = 0.57
Identities = 18/40 (45%), Positives = 23/40 (57%), Gaps = 3/40 (7%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINC 195
R+C E+E C +CI + CD NDCGD+SDE C
Sbjct: 2217 RTCSENE--FTC-GYGLCIPKIFRCDRHNDCGDYSDERGC 2253
Score = 36.3 bits (80), Expect = 1.00
Identities = 16/41 (39%), Positives = 27/41 (65%), Gaps = 3/41 (7%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCD 196
+ C E+E + C + + CI + +CD +DCGD+SDE+ C+
Sbjct: 3152 KPCTEYEYK--CGNGH-CIPHDNVCDDADDCGDWSDELGCN 3189
>X13916-1|CAA32112.1| 4544|Homo sapiens LDL-receptor related precursor
(AA -19 to 4525) protein.
Length = 4544
Score = 549 bits (1355), Expect = e-155
Identities = 318/908 (35%), Positives = 492/908 (54%), Gaps = 67/908 (7%)
Query: 800 DMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYL--NGSHQT--TIVDSNLIWPA 855
D + V +++ +ALD+ ++++WTDV +D I R L NG+ + ++ L P
Sbjct: 1288 DYSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPE 1347
Query: 856 GLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWG 915
GLA DWI IYW + ++IEV+K DG++RT L I+ PR I ++P G+++W+DW
Sbjct: 1348 GLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWD 1407
Query: 916 AS-PCIERADMDGGNRKKL--IFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTG 972
AS P IE A M G R+ + G WPNGL +D + RI W D + I A DG+G
Sbjct: 1408 ASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSG 1467
Query: 973 RTKLI---ENLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTG------------------ 1011
+++ E L HPF + LYG EV+WTDW T ++ ANK TG
Sbjct: 1468 HMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQV 1527
Query: 1012 --AKRRTLG---CGKN--NGGCSHLCLLKPGGR-SCACPIGIKLNKDGKTCADGPINYLI 1063
R+ + C N G CSHLCL+ SCACP +KL+KD TC + +L+
Sbjct: 1528 YHPSRQPMAPNPCEANGGQGPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYEFK-KFLL 1586
Query: 1064 FAHRVDIRVISLDVPYLIDVV-LPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLG 1122
+A +++IR + LD PY ++ +P + N +D D +YW+D + I+RA G
Sbjct: 1587 YARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFING 1646
Query: 1123 THVETVIGNGLHTADGIVIDSTGRKIYWT--DGGRNSIEVAELDGRNRKVLVWTGLDSPR 1180
T VETV+ L A G+ +D R ++WT D + I VA LDG + +V GL+ P
Sbjct: 1647 TGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPH 1705
Query: 1181 AIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDA 1240
+ +H G ++W+D I A+MDG+NR ++ + K P GLAID E +LYW +
Sbjct: 1706 GLVVHPLRGKLYWTD---GDNISMANMDGSNRTLLFSGQ-KGPVGLAIDFPESKLYWISS 1761
Query: 1241 KILTIESSDFDGHDRRTV---LSNVPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPI 1297
TI + DG + S + + I+G ++W D ++ + K + S +
Sbjct: 1762 GNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSV 1821
Query: 1298 VIRKNLEGLMDIR----AIQSERVLENACGTDNGGCSHLCL-RSPLGYTCACPTGMPFEK 1352
V+R + +M ++ +IQ + N C +NG CS LCL S +C C G
Sbjct: 1822 VLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRS 1881
Query: 1353 STTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDYHWDLKM 1412
+ C+ FL+++ I I L+ ++ D +PV + +D+H +
Sbjct: 1882 G-----QQACEG-VGSFLLYSVHEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDT 1935
Query: 1413 IFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARL 1472
I++ D+ L+ I S + + + +++ + G+ VDWIA NIYWTD VIEVARL
Sbjct: 1936 IYWVDMGLSTI-SRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARL 1994
Query: 1473 DGSSRKVLIT-GLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFP 1531
+GS R V+I+ GL +PRA+ + P KGYL+W++WG++P IERS LDG++R ++V V + +P
Sbjct: 1995 NGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWP 2054
Query: 1532 NGLTIDYKERRLYWTDALKDRIDTSDL-NGQHR-VQLVPDAKNPFGMTQFKDYIYWTD-- 1587
NG+++DY++ +LYW DA D+I+ DL G++R V L + + F ++ F+D+IYW+D
Sbjct: 2055 NGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRT 2114
Query: 1588 WYKKSIIRADKRTGKNITLIRTNLEMAM-EIKAVSADRQHGWNPCKESNGGCSHLCLFRG 1646
SI R K + +RT + + + +IK + DRQ G N C +NGGC LCL+RG
Sbjct: 2115 HANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRG 2174
Query: 1647 H-EYICAC 1653
+ CAC
Sbjct: 2175 RGQRACAC 2182
Score = 522 bits (1288), Expect = e-147
Identities = 358/1174 (30%), Positives = 579/1174 (49%), Gaps = 105/1174 (8%)
Query: 559 VFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTD--SGTRRVEVAT 616
++W E+NL I VA+++ + ++ +E P +A+D +LFWTD + R+E A+
Sbjct: 1358 IYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAAS 1417
Query: 617 LDGSKRAVL--VANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEI 674
+ G+ R + P + V + + W D + I A DG V+
Sbjct: 1418 MSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWID-ARSDAIYSARYDGSGHMEVLRGHE 1476
Query: 675 FWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYWTD 734
F + + ++YW D + + + +A V + PF L +Y
Sbjct: 1477 FLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQ-----VYHPS 1531
Query: 735 WHTKSISTVNKNTGMGI----------QTVHAGLNVPMDIH--SRSCEETPEKLLLYARR 782
+ + N G G +TV M +H + +C E +K LLYAR+
Sbjct: 1532 RQPMAPNPCEANGGQGPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYEF-KKFLLYARQ 1590
Query: 783 KDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSH 842
++R L++ P + + V I + LD+D + ++W+DV I RA++NG+
Sbjct: 1591 MEIRGVDLDA--PYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTG 1648
Query: 843 QTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNR--IEVSKSDGSMRTLLAWDHIDKPRDI 900
T+V ++L GLA DW++ ++WT TN+ I V++ DGS + + +++P +
Sbjct: 1649 VETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPHGL 1707
Query: 901 VVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGN 960
VV+P G +YW+D I A+MDG NR L GQ P GLA+D +++YW GN
Sbjct: 1708 VVHPLRGKLYWTD---GDNISMANMDGSNRTLLFSGQKG-PVGLAIDFPESKLYWISSGN 1763
Query: 961 KTIEYANLDGTGRTKLIENLPHPFG----LDLYGDEVFWTDWDTQSIQAANKDTGA---- 1012
TI NLDG+G ++I+ + G L + GD+++W D ++ + +K G+
Sbjct: 1764 HTINRCNLDGSG-LEVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVV 1822
Query: 1013 ---------------------KRRTLGCGKNNGGCSHLCL-LKPGGRSCACPIGIKLNKD 1050
+ T C NNG CS LCL RSC C G L +
Sbjct: 1823 LRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSL-RS 1881
Query: 1051 GKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNALGVDVDHSTGLIYWTDT 1110
G+ +G ++L+++ IR I LD D ++P+ A+G+D IYW D
Sbjct: 1882 GQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDM 1941
Query: 1111 GQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKV 1170
G I RA R T E V+ NG+ +GI +D IYWTD G + IEVA L+G R V
Sbjct: 1942 GLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYV 2001
Query: 1171 LVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDR 1230
++ GLD PRAI +H E GY+FW++WG +IER+ +DG R V+V+ I WPNG+++D
Sbjct: 2002 VISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWPNGISVDY 2061
Query: 1231 IEGRLYWNDAKILTIESSDFD-GHDRRTVL-SNVPYPYGIVIVGQHIYWTDWKTKA---L 1285
+G+LYW DA+ IE D + G +R VL SN + + + IYW+D +T A +
Sbjct: 2062 QDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSD-RTHANGSI 2120
Query: 1286 HRADKTNASDPIVIRKNL-EGLMDIRAIQSERVL-ENACGTDNGGCSHLCLRSPLGY-TC 1342
R K NA+D + +R + L DI+ +R N C NGGC LCL G C
Sbjct: 2121 KRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGRGQRAC 2180
Query: 1343 ACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTL-PVKE---V 1398
AC GM E + C+ + +L+++ R + I L + + P ++ +
Sbjct: 2181 ACAHGMLAEDGAS------CREY-AGYLLYSERTILKSIHLSDERNLNAPVQPFEDPEHM 2233
Query: 1399 KNTIAVDYHWDL-------KMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVD 1451
KN IA+ + + IF++D+ I+ IN + S TI+ + + + GL
Sbjct: 2234 KNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQIN-DDGSRRITIV-ENVGSVEGLAYH 2291
Query: 1452 WIANNIYWTDN-----EHKVIEVARLDGSSRKVLIT--GLTEPRALALFPAKGYLYWSDW 1504
+ +YWT ++ R R+ +IT G PRA L + ++W++W
Sbjct: 2292 RGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNW 2351
Query: 1505 GE-HPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHR 1563
E HP I R+ L G+ +++ D+ PNGL ID++ +LY++DA D+I+ + +G HR
Sbjct: 2352 NEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHR 2411
Query: 1564 -VQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNL-EMAMEIKAVS 1621
V L + +PFG+ + ++I+WTDW ++++ RA+K G N+ L+R ++ + M I AV+
Sbjct: 2412 YVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVA 2471
Query: 1622 ADRQH-GWNPCKESNGGCSHLCLFRGHEYI-CAC 1653
D +PC+ +NGGC LCL ++ C+C
Sbjct: 2472 NDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSC 2505
Score = 406 bits (999), Expect = e-112
Identities = 203/513 (39%), Positives = 291/513 (56%), Gaps = 17/513 (3%)
Query: 263 CAEIDFECKNTK-CVPKDFQCDGDNDCGDWTDEDSCP--MVPGSCNAGEFKCNDGKCIPE 319
C F C T CVP+ + CDGD DC D DE + +C+ EF C + +CIP+
Sbjct: 2774 CGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQNRQCIPK 2833
Query: 320 RWRCDNERDCADGGDEL-NCKPNSIRNCSLDEYTCADRRCVL-KTWLCDGVRDCTNGEDE 377
+ CD++RDCADG DE C+ C E+ CA+ RC+ + W CDG DC + DE
Sbjct: 2834 HFVCDHDRDCADGSDESPECE---YPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDE 2890
Query: 378 MNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAE- 436
C ++ C + ++ R CV +C+G DC DE C + S +
Sbjct: 2891 APKNPHCTSPEHKCNASSQFLCSSGR-CVAEALLCNGQDDCGDSSDERGCHINECLSRKL 2949
Query: 437 EKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCG 496
C + C G C C GF L +D +C D+DEC CSQ C NT GS++C
Sbjct: 2950 SGCSQDCEDLKIGFK-CRCRPGFRLKDDGRTCADVDECSTTFP--CSQRCINTHGSYKCL 3006
Query: 497 CMTGYILRP-DERSCKP-TGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHY 554
C+ GY R D SCK T E P L+F+NR +R++ L G NY + +GL+NAVALD+ Y
Sbjct: 3007 CVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDY 3066
Query: 555 EKKLVFWSENNLR--VIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRV 612
+++++W++ + +IR +N N+ + R GL P G+AVDW+ L+W D G +
Sbjct: 3067 REQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTI 3126
Query: 613 EVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYD 672
EV+ L+G+ R VLV++ L +PRA+ V + ++WTDWG + I R MDG R ++
Sbjct: 3127 EVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDT 3186
Query: 673 EIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYW 732
+I WPNGLT+DY +IYWADA+ IE A+ DG +R V ++ +PH FALTLF+D +YW
Sbjct: 3187 KITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYW 3246
Query: 733 TDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIH 765
TDW TKSI+ +K TG + + L+ PMD+H
Sbjct: 3247 TDWETKSINRAHKTTGTNKTLLISTLHRPMDLH 3279
Score = 386 bits (951), Expect = e-106
Identities = 197/522 (37%), Positives = 283/522 (54%), Gaps = 31/522 (5%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDE------DSCPMVPGSCNAGEFKCN-DGK 315
C+ F+C + +C+P+ + CDGDNDCGD++DE + PG C+ EF+C DG
Sbjct: 1015 CSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGL 1074
Query: 316 CIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADR-RCVLKTWLCDGVRDCTNG 374
CIP RWRCD + DC D DE +C+ + ++ C D RC+ K W+CDG DC +
Sbjct: 1075 CIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDN 1134
Query: 375 EDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE-ERCPLKRKC 433
DE NCE CRP H +N C+ +CDG DC G DE E C +C
Sbjct: 1135 SDEENCE------SLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCD---QC 1185
Query: 434 SAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGS 492
S C C C+CP+G L D ++C+ C CSQ C S
Sbjct: 1186 SLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLK--CSQKCDQNKFS 1243
Query: 493 FRCGCMTGYILRPDERSCKPTGE-SPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALD 551
+C C G++L PD SC+ P ++FSNR IR++ L +Y +V GL N +ALD
Sbjct: 1244 VKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALD 1303
Query: 552 YHYEKKLVFWSEN-NLRVIRVAQMNTKNMSD---VIRWGLETPAGVAVDWIHDLLFWTDS 607
+H + ++W++ ++ R ++ ++ VI++GL TP G+AVDWI ++W +S
Sbjct: 1304 FHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVES 1363
Query: 608 GTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPN-PKIERADMDGDKR 666
++EVA LDG+ R L+A D++ PRAIA+ P D ++FWTDW + P+IE A M G R
Sbjct: 1364 NLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGR 1423
Query: 667 KTVIYD--EIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTT--KGLPHPFA 722
+TV + WPNGLT+DY E +I W DA+ I A +DG +V + L HPFA
Sbjct: 1424 RTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFA 1483
Query: 723 LTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDI 764
+TL+ +YWTDW T +++ NK TG + V P D+
Sbjct: 1484 VTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDL 1525
Score = 330 bits (810), Expect = 4e-89
Identities = 207/645 (32%), Positives = 325/645 (50%), Gaps = 42/645 (6%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTCAD-GPIN-YLIFAHRVDIRVISLDVPYLIDV 1083
CS C C+C G L DG++C P ++IF++R +IR I L + D
Sbjct: 1233 CSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDL---HKGDY 1289
Query: 1084 VLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLG----THVETVIGNGLHTADGI 1139
+ +P L+N + +D S +YWTD + KI R L T E VI GL T +G+
Sbjct: 1290 SVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGL 1349
Query: 1140 VIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTS 1199
+D IYW + + IEVA+LDG R L+ ++ PRAIAL G +FW+DW S
Sbjct: 1350 AVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDAS 1409
Query: 1200 -AKIERADMDGNNRRVI--VDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRR 1256
+IE A M G RR + WPNGL +D +E R+ W DA+ I S+ +DG
Sbjct: 1410 LPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHM 1469
Query: 1257 TVLSN---VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQ 1313
VL + +P+ + + G +YWTDW+T L +A+K + V+++ D++
Sbjct: 1470 EVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYH 1529
Query: 1314 SER--VLENACGTD--NGGCSHLCL-RSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEE 1368
R + N C + G CSHLCL +CACP M K T C ++
Sbjct: 1530 PSRQPMAPNPCEANGGQGPCSHLCLINYNRTVSCACPHLMKLHKDNT-----TCYEF-KK 1583
Query: 1369 FLIFATRGSITYISLESP-EQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSIN 1427
FL++A + I + L++P + ++ V ++ N +DY + ++++D+ I+
Sbjct: 1584 FLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRA- 1642
Query: 1428 MTNMSESKTIISQKLETPNGLGVDWIANNIYWT--DNEHKVIEVARLDGSSRKVLITGLT 1485
N + +T++S L +GL VDW++ N++WT D K I VARLDGS + ++ GL
Sbjct: 1643 FINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVVQGLE 1702
Query: 1486 EPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYW 1545
+P L + P +G LYW+D G++ I + +DGS R ++ G P GL ID+ E +LYW
Sbjct: 1703 QPHGLVVHPLRGKLYWTD-GDN--ISMANMDGSNRTLLFSGQKG-PVGLAIDFPESKLYW 1758
Query: 1546 TDALKDRIDTSDLNGQHRVQLVPDAKNPFG----MTQFKDYIYWTDWYKKSIIRADKRTG 1601
+ I+ +L+G ++++ ++ G + D ++W D + + K G
Sbjct: 1759 ISSGNHTINRCNLDGS-GLEVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADG 1817
Query: 1602 KNITLIR--TNLEMAMEIKAVSADRQH-GWNPCKESNGGCSHLCL 1643
++R T L M M++ S H G NPC +NG CS LCL
Sbjct: 1818 SGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQLCL 1862
Score = 301 bits (740), Expect = 1e-80
Identities = 211/684 (30%), Positives = 338/684 (49%), Gaps = 60/684 (8%)
Query: 1024 GGCSHLCLLKPGGRSCACPIGIKLNKDGKTCA--DGPIN---YLIFAHRVDIRVISLDVP 1078
G CS LC G C C G L D ++C + P++ L+ A+ +I L
Sbjct: 158 GTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGA 217
Query: 1079 YLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTG------QRKIQRATRLGTHVE--TV-I 1129
+ + P + +D ++ + W G Q K R L V+ T+ I
Sbjct: 218 Q-VSTITPTST-RQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINI 275
Query: 1130 GNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYG 1189
LH + + ID Y+ D + I V +G L+ L +P+ IAL G
Sbjct: 276 SLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMG 335
Query: 1190 YMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSD 1249
+F++D+G K+ER DMDG NR +VD+KI +P+G+ +D + +YW DA + IE D
Sbjct: 336 KVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVD 395
Query: 1250 FDGHDRRTVLSN--VPYPYGIVIVGQHIYWTD-------WKTKALHRADKTNASD-PIVI 1299
++G R+T++ + + YG+ + ++Y T+ KT + R ++ N+++ +V
Sbjct: 396 YEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVI-RVNRFNSTEYQVVT 454
Query: 1300 RKNLEGLMDI-RAIQSERVLENACGTDN----GGCSHLCL--RSPLGYTCACPTGMPFEK 1352
R + G + I + RV +AC D GGCS +CL S TC C +G
Sbjct: 455 RVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGF---- 510
Query: 1353 STTDQTPKKCKSHPEE-FLIF--ATRGSITYISLESPEQWDVTLPVKEVKNTIAVDYHWD 1409
+ K CK E FL++ G I + + + + +P++ + N A+D+H +
Sbjct: 511 -SLGSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAE 569
Query: 1410 LKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDN-EHKVIE 1468
I++ D +I + +E +TI+ + G+ VDW+ +N+YWTD+ K I
Sbjct: 570 TGFIYFADTTSYLIGRQKIDG-TERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTIS 628
Query: 1469 VARLD--GSSRKVLITG-LTEPRALALFPAKGYLYWSDWGEHP------YIERSYLDGSQ 1519
VARL+ +RK LI G +T PRA+ + P G++YW+DW E P +ER+++DGS
Sbjct: 629 VARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSH 688
Query: 1520 RQIIV-QVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHR--VQLVPDAKNPFGM 1576
R I V + +PNGL++D RLYW DA DRI+T LNG R V P+ + FG+
Sbjct: 689 RDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGL 748
Query: 1577 TQFKDYIYWTDWYKKSIIRADKRTG---KNITLIRTNLEMAMEIKAVSADRQH-GWNPCK 1632
+Y++WT++ S+ R ++ G +TL+R+ EI+ A +Q G N C+
Sbjct: 749 CHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCR 808
Query: 1633 ESNGGCSHLCLFRGHEYICACPDD 1656
+NGGCS LCL CAC +D
Sbjct: 809 VNNGGCSSLCLATPGSRQCACAED 832
Score = 284 bits (696), Expect = 2e-75
Identities = 174/543 (32%), Positives = 266/543 (48%), Gaps = 38/543 (6%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
RC F+CK+ C+P ++CD D DC D +DE++C +C EF+CN+ C P W
Sbjct: 3612 RCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAW 3671
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDE-YTCA-DRRCVLKTWLCDGVRDCTNGEDEMN 379
+CD E DC D DE N + + C + + C DR C+ CDG +C +G DE +
Sbjct: 3672 KCDGEDDCGDNSDE-NPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEED 3730
Query: 380 CEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRK---CSAE 436
CE + +E L N + C++ C+ DC G DEE C + K C+
Sbjct: 3731 CEPPTAHTTHCKDKKEFLCRN--QRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATN 3788
Query: 437 EK-C--EKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSF 493
C E C+ T + A CAC GF + C+DI+EC+ + CSQ C+NT G
Sbjct: 3789 ASICGDEARCVRT-EKAAYCACRSGFHTVPGQPGCQDINECL--RFGTCSQLCNNTKGGH 3845
Query: 494 RCGCMTGYILRPDERSCKPTG-ESPTLLFSNRIGIRQVWLTGDN--YMSVVKGLHNA--V 548
C C ++ +CK G E L ++ IR ++ + Y +G +
Sbjct: 3846 LCSCARNFM--KTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGDESVRID 3903
Query: 549 ALDYHYEKKLVFWSENNLRVIR------VAQMNTKN---------MSDVIRWGLETPAGV 593
A+D H + V+W+ + I A T N ++ + GL+ P G+
Sbjct: 3904 AMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGI 3963
Query: 594 AVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPN 653
A+DW+ ++WTDSG +EVA + G R L++ +D+P AI V P ++W+DWG +
Sbjct: 3964 AIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNH 4023
Query: 654 PKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDR--RK 711
PKIE A MDG R+T++ D I WP GL +DY ++YWADAK VI +G D
Sbjct: 4024 PKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAA 4083
Query: 712 VTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEE 771
+ +GL HPF++ +F+D IY + + ++K + + GL+ D+ +
Sbjct: 4084 DSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHK 4143
Query: 772 TPE 774
PE
Sbjct: 4144 QPE 4146
Score = 253 bits (619), Expect = 5e-66
Identities = 136/335 (40%), Positives = 198/335 (59%), Gaps = 17/335 (5%)
Query: 1329 CSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEE--FLIFATRGSITYISLESP 1386
CS C+ + Y C C G + P CK+ +E FLIFA R + ++L+
Sbjct: 2992 CSQRCINTHGSYKCLCVEGY----APRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGS 3047
Query: 1387 EQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDL--NVIRSINMTNMSESKTIISQKLET 1444
+ TL + + N +A+D+ + +MI++TD+ ++IR +++ N S + + L
Sbjct: 3048 ---NYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHL-NGSNVQVLHRTGLSN 3103
Query: 1445 PNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLIT-GLTEPRALALFPAKGYLYWSD 1503
P+GL VDW+ N+YW D IEV++L+G+ R VL++ GL EPRAL + GYLYW+D
Sbjct: 3104 PDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTD 3163
Query: 1504 WGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHR 1563
WG+H I R +DGS R +IV + +PNGLT+DY R+YW DA +D I+ + L+G +R
Sbjct: 3164 WGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNR 3223
Query: 1564 -VQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAVSA 1622
V L D + F +T F+DY+YWTDW KSI RA K TG N TL+ + L M++ A
Sbjct: 3224 HVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHA 3283
Query: 1623 DRQHGW--NPCKESNGGCSHLCLFR-GHEYICACP 1654
RQ +PCK +NGGCS+LCL G + CACP
Sbjct: 3284 LRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACP 3318
Score = 249 bits (609), Expect = 8e-65
Identities = 236/838 (28%), Positives = 361/838 (43%), Gaps = 95/838 (11%)
Query: 301 PGSCNAGEFKCNDG-KCIPERWRCDNERDCADGGDELN--CKPNSIRNCSLDEYTCADRR 357
P +C+ +F C D CI + WRCD ERDC DG DE C + + C +E+ C
Sbjct: 24 PKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTE 83
Query: 358 -CVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKH--VCDG 414
CV + LC+GV+DC +G DE C E Q C +CV C
Sbjct: 84 LCVPMSRLCNGVQDCMDGSDE---GPHCRELQGNCS-----RLGCQHHCVPTLDGPTCYC 135
Query: 415 MKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
D + C +CS C +LC T DG C C G+LL D SC+ +E
Sbjct: 136 NSSFQLQADGKTCKDFDECSVYGTCSQLCTNT-DGSFICGCVEGYLLQPDNRSCKAKNEP 194
Query: 475 MYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGES---PTLLFSNRIG--IRQ 529
+ + N + ++ G I R S T+ + + +G Q
Sbjct: 195 VDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVH-VGDSAAQ 253
Query: 530 VWLTGDNYMSVVKGLHNAVALD-----YHYEKKLVFWSENNLRVI-----RVAQMNTKNM 579
L M +KG + ++ +H E+ + W N + R+ N
Sbjct: 254 TQLKCAR-MPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGD 312
Query: 580 SDVIRWGLE--TPAGVAVDWIHDLLFWTDSGT-RRVEVATLDGSKRAVLVANDLDKPRAI 636
+ V LE P G+A+D +F+TD G +VE +DG R LV + + P I
Sbjct: 313 TCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGI 372
Query: 637 AVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWP-NGLTI--DY---TESKIY 690
+ LV+W D IE D +G R+T+I + GLT+ +Y T S
Sbjct: 373 TLDLVSRLVYWAD-AYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNA 431
Query: 691 WADAKHHVIERAAFDGRDRRKVTT--KG----LPHPFALTLFDDAIYWTDWHTK-----S 739
A K VI F+ + + VT KG + H D + K
Sbjct: 432 NAQQKTSVIRVNRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSD 491
Query: 740 ISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKL-LLYARRKDLRLKQLESKKPIDS 798
I + + +G ++ D +SC++ +L L+Y + + ++ ++ +
Sbjct: 492 ICLLANSHKARTCRCRSGFSLGSD--GKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPD 549
Query: 799 LDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLA 858
M IP+E + + ALD+ ++ I++ D I R ++G+ + TI+ + G+A
Sbjct: 550 EHM-IPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVA 608
Query: 859 FDWITDKIYWTDGGTNR-IEVSKSDGSMRT--LLAWDHIDKPRDIVVNPEGGVMYWSDWG 915
DW+ D +YWTD G + I V++ + + +T L + PR IVV+P G MYW+DW
Sbjct: 609 VDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWE 668
Query: 916 ASP------CIERADMDGGNRKKLIFGQ-MTWPNGLALDLVHNRIYWTDGGNKTIEYANL 968
P +ERA MDG +R + + + WPNGL+LD+ R+YW D IE L
Sbjct: 669 EDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILL 728
Query: 969 DGTGRTKLIE--NLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTG--------------- 1011
+GT R + E L H FGL +G+ +FWT++ + S+ + G
Sbjct: 729 NGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPP 788
Query: 1012 --------AKRRTLG---CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGP 1058
A+++ +G C NNGGCS LCL PG R CAC L+ DG TC P
Sbjct: 789 IFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANP 846
Score = 246 bits (602), Expect = 6e-64
Identities = 130/331 (39%), Positives = 194/331 (58%), Gaps = 13/331 (3%)
Query: 1026 CSHLCLLKPGGRSCACPIGIK-LNKDGKTC--ADGPINYLIFAHRVDIRVISLDVPYLID 1082
CS C+ G C C G D +C +LIFA+R +R ++LD +
Sbjct: 2992 CSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGS---N 3048
Query: 1083 VVLPLPPLKNALGVDVDHSTGLIYWTD-TGQRKIQRATRL-GTHVETVIGNGLHTADGIV 1140
L L NA+ +D D+ +IYWTD T Q + R L G++V+ + GL DG+
Sbjct: 3049 YTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLA 3108
Query: 1141 IDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSA 1200
+D G +YW D GR++IEV++L+G R VLV +GL PRA+ + + GY++W+DWG +
Sbjct: 3109 VDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHS 3168
Query: 1201 KIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLS 1260
I R MDG++R VIVD KI WPNGL +D + R+YW DA+ IE + DG +R VLS
Sbjct: 3169 LIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLS 3228
Query: 1261 -NVPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDI---RAIQSER 1316
++P+ + + + ++YWTDW+TK+++RA KT ++ ++ L MD+ A++
Sbjct: 3229 QDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPD 3288
Query: 1317 VLENACGTDNGGCSHLCLRSP-LGYTCACPT 1346
V + C +NGGCS+LCL SP G+ CACPT
Sbjct: 3289 VPNHPCKVNNGGCSNLCLLSPGGGHKCACPT 3319
Score = 235 bits (576), Expect = 8e-61
Identities = 128/320 (40%), Positives = 176/320 (55%), Gaps = 34/320 (10%)
Query: 763 DIHSRSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNS 822
D HS E L++A R LR K +D + + + + +AVALD+D +
Sbjct: 3017 DPHSCKAVTDEEPFLIFANRYYLR------KLNLDGSNYTLLKQGLNNAVALDFDYREQM 3070
Query: 823 IFWTDV--EKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSK 880
I+WTDV + I R +LNGS+ + + L P GLA DW+ +YW D G + IEVSK
Sbjct: 3071 IYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSK 3130
Query: 881 SDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTW 940
+G+ RT+L + +PR +VV+ + G +YW+DWG I R MDG +R ++ ++TW
Sbjct: 3131 LNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITW 3190
Query: 941 PNGLALDLVHNRIYWTDGGNKTIEYANLDGTGR-TKLIENLPHPFGLDLYGDEVFWTDWD 999
PNGL LD V RIYW D IE+A+LDG+ R L +++PH F L L+ D V+WTDW+
Sbjct: 3191 PNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWE 3250
Query: 1000 TQSIQAANKDTGAKRRTL------------------------GCGKNNGGCSHLCLLKP- 1034
T+SI A+K TG + L C NNGGCS+LCLL P
Sbjct: 3251 TKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPG 3310
Query: 1035 GGRSCACPIGIKLNKDGKTC 1054
GG CACP L DG+TC
Sbjct: 3311 GGHKCACPTNFYLGSDGRTC 3330
Score = 206 bits (504), Expect = 4e-52
Identities = 152/492 (30%), Positives = 222/492 (45%), Gaps = 38/492 (7%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKC-NDGKCIPERW 321
C+E FEC+N +C+ K + CDG +DCGD +DE + +C F C C+PERW
Sbjct: 2734 CSEAQFECQNHRCISKQWLCDGSDDCGDGSDE-AAHCEGKTCGPSSFSCPGTHVCVPERW 2792
Query: 322 RCDNERDCADGGDE---LNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEM 378
CD ++DCADG DE C NS C E+ C +R+C+ K ++CD RDC +G DE
Sbjct: 2793 LCDGDKDCADGADESIAAGCLYNS--TCDDREFMCQNRQCIPKHFVCDHDRDCADGSDE- 2849
Query: 379 NCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKC-SAEE 437
S E + TC P E +N R +R+ CDG DC D + P C S E
Sbjct: 2850 ----SPECEYPTCGPSEFRCANG-RCLSSRQWECDGENDC--HDQSDEAPKNPHCTSPEH 2902
Query: 438 KC----EKLCITTYDGHAACACPMGFLLAE--DKYSCRDIDECMYEQDPVCSQTCSNTVG 491
KC + LC + A C + D+ C I+EC+ + CSQ C +
Sbjct: 2903 KCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCH-INECLSRKLSGCSQDCEDLKI 2961
Query: 492 SFRCGCMTGYILRPDERSCKPTGE-SPTLLFSNR-IGIRQVW--LTGDNYMSVVKGLHNA 547
F+C C G+ L+ D R+C E S T S R I + L + Y H+
Sbjct: 2962 GFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTHGSYKCLCVEGYAPRGGDPHSC 3021
Query: 548 VALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDS 607
A+ E L+F + LR + + N +++ GL + D+ +++WTD
Sbjct: 3022 KAVT-DEEPFLIFANRYYLRKLNLDGSN----YTLLKQGLNNAVALDFDYREQMIYWTDV 3076
Query: 608 GTR--RVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDK 665
T+ + L+GS VL L P +AV ++W D G IE + ++G
Sbjct: 3077 TTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKG-RDTIEVSKLNGAY 3135
Query: 666 RKTVIYDEIFWPNGLTIDYTESKIYWAD-AKHHVIERAAFDGRDRRKVTTKGLPHPFALT 724
R ++ + P L +D +YW D H +I R DG R + + P LT
Sbjct: 3136 RTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLT 3195
Query: 725 L--FDDAIYWTD 734
L + IYW D
Sbjct: 3196 LDYVTERIYWAD 3207
Score = 198 bits (484), Expect = 1e-49
Identities = 106/288 (36%), Positives = 160/288 (55%), Gaps = 9/288 (3%)
Query: 482 CSQTCSNTVGSFR-CGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSV 540
CSQ C T + R C C GY LR +++C+ G LL+S GIR + L ++
Sbjct: 1857 CSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGSF--LLYSVHEGIRGIPLDPNDKSDA 1914
Query: 541 ---VKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDW 597
V G AV +D+H E ++W + L I A+ + DV+ G+ G+AVDW
Sbjct: 1915 LVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDW 1974
Query: 598 IHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIE 657
I ++WTD G +EVA L+GS R V+++ LDKPRAI VHP +FWT+WG P+IE
Sbjct: 1975 IAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIE 2034
Query: 658 RADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFD-GRDRRKVTTKG 716
R+ +DG +R ++ I WPNG+++DY + K+YW DA+ IER + G +R V +
Sbjct: 2035 RSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSN 2094
Query: 717 LPHPFALTLFDDAIYWTD-WHTK-SISTVNKNTGMGIQTVHAGLNVPM 762
F++++F+D IYW+D H SI +K+ + G+ V +
Sbjct: 2095 NMDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQL 2142
Score = 191 bits (465), Expect = 2e-47
Identities = 174/615 (28%), Positives = 253/615 (41%), Gaps = 78/615 (12%)
Query: 158 CDEH---ENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIG 214
C +H +R C + N CI WLCDGDNDCG+ DE N ++ P S G
Sbjct: 890 CHQHTCPSDRFKCEN-NRCIPNRWLCDGDNDCGNSEDESNATC--SARTCPPNQFSCASG 946
Query: 215 DVITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEI-DFECKNT 273
I I+ T C LD+ RS + C + F C N
Sbjct: 947 RCIP-----ISWT-----------C---DLDDDCGDRSDESASCAYPTCFPLTQFTCNNG 987
Query: 274 KCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGG 333
+C+ +++CD DNDCGD +DE C SC++ +FKCN G+CIPE W CD + DC D
Sbjct: 988 RCININWRCDNDNDCGDNSDEAGC---SHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYS 1044
Query: 334 DE--LNCKPNSIR---NCSLDEYTC-ADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEED 387
DE NC + R C DE+ C D C+ W CDG DC + DE SCE
Sbjct: 1045 DETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEK----SCEGV 1100
Query: 388 QYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC------PLKRKCSAEEK-C- 439
+ C P C+++ VCDG DC DEE C P C+ C
Sbjct: 1101 THVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCL 1160
Query: 440 --EKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVG-SFRCG 496
+KLC DG+ C +++ C D+C CS CS G C
Sbjct: 1161 PPDKLC----DGNDDCGDG-----SDEGELC---DQCSLNNGG-CSHNCSVAPGEGIVCS 1207
Query: 497 CMTGYILRPDERSCKPTGE-SPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYE 555
C G L PD +C+ + L S + + + Y V
Sbjct: 1208 CPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPF 1267
Query: 556 KKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVA 615
K + +S N IR ++ + S V+ GL + L+WTD ++
Sbjct: 1268 KPFIIFS--NRHEIRRIDLHKGDYS-VLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRG 1324
Query: 616 TL--DGSKRA--VLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIY 671
L +G+ + V++ L P +AV ++W + + +IE A +DG R T++
Sbjct: 1325 KLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLD-QIEVAKLDGTLRTTLLA 1383
Query: 672 DEIFWPNGLTIDYTESKIYWA--DAKHHVIERAAFDGRDRRKVTTK----GLPHPFALTL 725
+I P + +D + ++W DA IE A+ G RR V + G P+ +
Sbjct: 1384 GDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDY 1443
Query: 726 FDDAIYWTDWHTKSI 740
+ I W D + +I
Sbjct: 1444 LEKRILWIDARSDAI 1458
Score = 180 bits (438), Expect = 4e-44
Identities = 156/549 (28%), Positives = 252/549 (45%), Gaps = 63/549 (11%)
Query: 559 VFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTR-RVEVATL 617
++W++ VI VA++N VI GL+ P + V LFWT+ G R+E + L
Sbjct: 1979 IYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRL 2038
Query: 618 DGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMD-GDKRKTVIYDEIFW 676
DG++R VLV + P I+V D ++W D KIER D++ G+ R+ V+
Sbjct: 2039 DGTERVVLVNVSISWPNGISVDYQDGKLYWCD-ARTDKIERIDLETGENREVVLSSNNM- 2096
Query: 677 PNGLTIDYTESKIYWADAKHH--VIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYWTD 734
+ ++ E IYW+D H I+R + D G+ + L D ++ D
Sbjct: 2097 -DMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGI----GVQLKDIKVFNRD 2151
Query: 735 WHTKSISTVNKNTGMGIQTVHAG--------LNVPMDIHSRSCEETPEKLLLYARRKDLR 786
+ N G ++ G + + SC E LLY+ R L+
Sbjct: 2152 RQKGTNVCAVANGGCQQLCLYRGRGQRACACAHGMLAEDGASCREYAG-YLLYSERTILK 2210
Query: 787 LKQLESKKPIDS-LDMVIPVETIKSAVALDWDQKS-------NSIFWTDVEKDTINRAYL 838
L ++ +++ + E +K+ +AL +D ++ N IF++D+ I +
Sbjct: 2211 SIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQIND 2270
Query: 839 NGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSM------RTLLAWD 892
+GS + TIV+ N+ GLA+ D +YWT T+ I D + T++
Sbjct: 2271 DGSRRITIVE-NVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMS 2329
Query: 893 HIDKPRDIVVNPEGGVMYWSDWGAS-PCIERADMDGGNRKKLIFGQMTWPNGLALDLVHN 951
D PR V++ +M+W++W P I RA + G N LI + PNGLA+D
Sbjct: 2330 GDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAE 2389
Query: 952 RIYWTDGGNKTIEYANLDGTGRTKLIENLP-HPFGLDLYGDEVFWTDWDTQSIQAANKDT 1010
++Y++D IE DG+ R ++++ P HPFGL +YG+ +FWTDW +++Q ANK
Sbjct: 2390 KLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHV 2449
Query: 1011 GAKRRTLG------------------------CGKNNGGCSHLCLLKPGGR-SCACPIGI 1045
G+ + L C NNGGC LCLL G +C+C G
Sbjct: 2450 GSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCR-GG 2508
Query: 1046 KLNKDGKTC 1054
++ +D TC
Sbjct: 2509 RILQDDLTC 2517
Score = 173 bits (422), Expect = 4e-42
Identities = 99/297 (33%), Positives = 142/297 (47%), Gaps = 34/297 (11%)
Query: 169 STNVCIALEWLCDGDNDCGDFSDEINCDV----------VKTSLLVPS---ANASLNIGD 215
ST +C ++CDGDNDC D SDE NCD+ T+ +P N N GD
Sbjct: 3382 STGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGD 3441
Query: 216 VITN---PTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVEL--MRCAEIDFEC 270
P V A + I D + ++P M C +F C
Sbjct: 3442 GEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRC 3501
Query: 271 KNT-KCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDC 329
K++ +C+P ++CDG++DCGD +DE +C +F+C + +C+P RW+CD + DC
Sbjct: 3502 KDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDC 3561
Query: 330 ADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQY 389
D DE +C P R CS E++CA+ RC+ W CDG DC +G DE +C C+ DQ+
Sbjct: 3562 GDNSDEESCTP---RPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQF 3618
Query: 390 TCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPL-KRKCSAEE-KCEK-LC 443
C+ +C+ + CD DC G DEE C R C +E +C LC
Sbjct: 3619 QCKS---------GHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLC 3666
Score = 164 bits (399), Expect = 2e-39
Identities = 108/352 (30%), Positives = 166/352 (47%), Gaps = 33/352 (9%)
Query: 1327 GGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEF--LIFATRGSITYISLE 1384
G CS LC + G+ C+C F K T CK+ E+ L A I +
Sbjct: 3832 GTCSQLCNNTKGGHLCSCARN--FMK-----THNTCKAEGSEYQVLYIADDNEIRSLFPG 3884
Query: 1385 SPEQ-WDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVI--RSINM----TNMSESKTI 1437
P ++ E A+D H +++T+ I RS+ T + +
Sbjct: 3885 HPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQ 3944
Query: 1438 ISQK--------LETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITGLT-EPR 1488
I + L+ P G+ +DW+A N+YWTD+ VIEVA++ G +RK LI+G+ EP
Sbjct: 3945 IDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPH 4004
Query: 1489 ALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDA 1548
A+ + P +G +YWSDWG HP IE + +DG+ R+ +VQ ++ +P GL +DY RLYW DA
Sbjct: 4005 AIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADA 4064
Query: 1549 LKDRIDTSDLNGQHRVQLVPDAK----NPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNI 1604
I + LNG + + D+K +PF + F+DYIY + + + K +
Sbjct: 4065 KLSVIGSIRLNGTDPI-VAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPL 4123
Query: 1605 TLIRTNLEMAMEIKAVSADRQ-HGWNPCKESNGGCSHLCLFRGHEYICACPD 1655
+ L A ++ +Q NPC C LCL +C CP+
Sbjct: 4124 VNLTGGLSHASDVVLYHQHKQPEVTNPCDRKK--CEWLCLLSPSGPVCTCPN 4173
Score = 159 bits (385), Expect = 1e-37
Identities = 112/360 (31%), Positives = 153/360 (42%), Gaps = 29/360 (8%)
Query: 1024 GGCSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGP-INYLIFAHRVDIRVISLDVPY-L 1080
G CS LC GG C+C K TC A+G L A +IR + P+
Sbjct: 3832 GTCSQLCNNTKGGHLCSCARNFM--KTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSA 3889
Query: 1081 IDVVLPLPPLKNALGVDVDHSTGLIYWTD------------------TGQRKIQRATRLG 1122
+ +DV G +YWT+ T R ++ R
Sbjct: 3890 YEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGV 3949
Query: 1123 THVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAI 1182
TH+ +GL GI ID +YWTD GR+ IEVA++ G NRK L+ +D P AI
Sbjct: 3950 THLNI---SGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAI 4006
Query: 1183 ALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKI 1242
+ G M+WSDWG KIE A MDG R +V + I+WP GLA+D RLYW DAK+
Sbjct: 4007 VVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKL 4066
Query: 1243 LTIESSDFDGHDRRTVLSN---VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVI 1299
I S +G D + + +P+ I + +IY + + + K S + +
Sbjct: 4067 SVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNL 4126
Query: 1300 RKNLEGLMDIRAIQSERVLENACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTP 1359
L D+ + E D C LCL SP G C CP G + T P
Sbjct: 4127 TGGLSHASDVVLYHQHKQPEVTNPCDRKKCEWLCLLSPSGPVCTCPNGKRLDNGTCVPVP 4186
Score = 137 bits (332), Expect = 3e-31
Identities = 100/336 (29%), Positives = 145/336 (43%), Gaps = 42/336 (12%)
Query: 762 MDIHSRSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSN 821
M H+ E E +LY D ++ L P + + + A+D K+
Sbjct: 3854 MKTHNTCKAEGSEYQVLYIA-DDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHVKAG 3912
Query: 822 SIFWTDVEKDTINRAYL--------NGSHQ-------TTIVDSNLIWPAGLAFDWITDKI 866
++WT+ TI+ L + H+ T + S L P G+A DW+ +
Sbjct: 3913 RVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNV 3972
Query: 867 YWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMD 926
YWTD G + IEV++ G R L ID+P IVV+P G MYWSDWG P IE A MD
Sbjct: 3973 YWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMD 4032
Query: 927 GGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN---LPHP 983
G R+ L+ + WP GLA+D + R+YW D I L+GT ++ L HP
Sbjct: 4033 GTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHP 4092
Query: 984 FGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTLGCGKNNGG------------------ 1025
F +D++ D ++ + + +K + L G ++
Sbjct: 4093 FSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVTNPCD 4152
Query: 1026 ---CSHLCLLKPGGRSCACPIGIKLNKDGKTCADGP 1058
C LCLL P G C CP G +L D TC P
Sbjct: 4153 RKKCEWLCLLSPSGPVCTCPNGKRL--DNGTCVPVP 4186
Score = 136 bits (330), Expect = 5e-31
Identities = 90/261 (34%), Positives = 122/261 (46%), Gaps = 33/261 (12%)
Query: 169 STNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTK 228
S C++ C+G +DCGD SDEI C+ KT+ V G I N +
Sbjct: 2574 SNGRCVSNMLWCNGADDCGDGSDEIPCN--KTACGVGEFRC--RDGTCIGNSS------- 2622
Query: 229 PTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFE-CKNTK-CVPKDFQCDGDN 286
R F + + N +T + + F+ C+ T C + CDG N
Sbjct: 2623 -----RCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGAN 2677
Query: 287 DCGDWTDEDSCPMVPGS-CNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRN 345
DCGD++DE CP V C F C G+CIP W CD E DC G DE +C +
Sbjct: 2678 DCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCN----KF 2733
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDE-MNCE-VSCEEDQYTCRPQEHLMSNAFR 403
CS ++ C + RC+ K WLCDG DC +G DE +CE +C ++C P H+
Sbjct: 2734 CSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSC-PGTHV------ 2786
Query: 404 NCVNRKHVCDGMKDCPRGDDE 424
CV + +CDG KDC G DE
Sbjct: 2787 -CVPERWLCDGDKDCADGADE 2806
Score = 132 bits (318), Expect = 1e-29
Identities = 87/278 (31%), Positives = 135/278 (48%), Gaps = 16/278 (5%)
Query: 482 CSQTCS-NTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSV 540
CS C N + C C L D +C + LL++ ++ IR V L Y +
Sbjct: 1549 CSHLCLINYNRTVSCACPHLMKLHKDNTTCYEFKKF--LLYARQMEIRGVDLDAPYYNYI 1606
Query: 541 VK----GLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVD 596
+ + N LDY ++ V+WS+ + I+ A +N + V+ L G+AVD
Sbjct: 1607 ISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVD 1666
Query: 597 WIHDLLFWT--DSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNP 654
W+ LFWT D+ +++ VA LDGS + +V L++P + VHP ++WTD G N
Sbjct: 1667 WVSRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPHGLVVHPLRGKLYWTD-GDN- 1723
Query: 655 KIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTT 714
I A+MDG R T+++ P GL ID+ ESK+YW + +H I R DG +
Sbjct: 1724 -ISMANMDGSNR-TLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDA 1781
Query: 715 --KGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMG 750
L AL + D ++W D ++ + T +K G G
Sbjct: 1782 MRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSG 1819
Score = 128 bits (310), Expect = 1e-28
Identities = 71/197 (36%), Positives = 96/197 (48%), Gaps = 14/197 (7%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
+C +F C N++C+ + ++CDGDNDC D +DE +C + FKC + +CIP RW
Sbjct: 853 QCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRW 912
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCE 381
CD + DC + DE N S R C ++++CA RC+ +W CD DC + DE
Sbjct: 913 LCDGDNDCGNSEDESNA-TCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDE---S 968
Query: 382 VSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE-KCE 440
SC TC P N R C+N CD DC DE C CS+ + KC
Sbjct: 969 ASCAYP--TCFPLTQFTCNNGR-CININWRCDNDNDCGDNSDEAGC--SHSCSSTQFKCN 1023
Query: 441 K-LCIT---TYDGHAAC 453
CI T DG C
Sbjct: 1024 SGRCIPEHWTCDGDNDC 1040
Score = 125 bits (301), Expect = 2e-27
Identities = 64/182 (35%), Positives = 94/182 (51%), Gaps = 17/182 (9%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDE-DSCPMVPGSCNAGEFKCNDGKCIPERW 321
C F CKN KC+P ++CD ++DCGD +DE CP C G+F+C+ G C +
Sbjct: 3334 CTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEF--KCRPGQFQCSTGICTNPAF 3391
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNC 380
CD + DC D DE NC I C ++ C + RC+ + C+G +C +GEDE +C
Sbjct: 3392 ICDGDNDCQDNSDEANC---DIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDC 3448
Query: 381 -EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE-K 438
EV+C +Q+ C + + C+ R VCD DC G DE + C +E +
Sbjct: 3449 PEVTCAPNQFQC--------SITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFR 3500
Query: 439 CE 440
C+
Sbjct: 3501 CK 3502
Score = 124 bits (298), Expect = 4e-27
Identities = 88/281 (31%), Positives = 120/281 (42%), Gaps = 43/281 (15%)
Query: 173 CIALEWLCDGDNDCGDFSDE-INCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTV 231
CI W CD ++DCGD SDE +C K + G + TNP +
Sbjct: 3346 CIPFWWKCDTEDDCGDHSDEPPDCPEFKCR----PGQFQCSTG-ICTNPAFICDGDNDCQ 3400
Query: 232 VIRYESFC-AKKALDNAANPRSTWNQPVELMRC--------AEIDFECKNTKCVPKDFQ- 281
E+ C L + +T + RC E + +C C P FQ
Sbjct: 3401 DNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQC 3460
Query: 282 ------------CDGDNDCGDWTDED-SCPMVPGSCNAGEFKCND-GKCIPERWRCDNER 327
CD DNDC D +DE +C + +C EF+C D G+CIP RW+CD E
Sbjct: 3461 SITKRCIPRVWVCDRDNDCVDGSDEPANCTQM--TCGVDEFRCKDSGRCIPARWKCDGED 3518
Query: 328 DCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV-SCEE 386
DC DG DE + + R C ++ C + RCV W CD DC + DE +C C E
Sbjct: 3519 DCGDGSDEPKEECDE-RTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSE 3577
Query: 387 DQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC 427
+++C A C+ + CDG DC G DE+ C
Sbjct: 3578 SEFSC---------ANGRCIAGRWKCDGDHDCADGSDEKDC 3609
Score = 123 bits (297), Expect = 5e-27
Identities = 82/271 (30%), Positives = 122/271 (45%), Gaps = 26/271 (9%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALT-KPTV 231
CI C+ DC D SDE+NC S + L + V+ P +L P+
Sbjct: 2617 CIGNSSRCNQFVDCEDASDEMNCSATDCS-----SYFRLGVKGVLFQPCERTSLCYAPSW 2671
Query: 232 VIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDW 291
V + C + D P V+ RC F C + +C+P + CD ++DC
Sbjct: 2672 VCDGANDCGDYS-DERDCPG------VKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHG 2724
Query: 292 TDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDE-LNCKPNSIRNCSLDE 350
DE C C+ +F+C + +CI ++W CD DC DG DE +C+ + C
Sbjct: 2725 EDETHCNKF---CSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEG---KTCGPSS 2778
Query: 351 YTCADRR-CVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRK 409
++C CV + WLCDG +DC +G DE + C + TC +E + N R C+ +
Sbjct: 2779 FSCPGTHVCVPERWLCDGDKDCADGADE-SIAAGCLYNS-TCDDREFMCQN--RQCIPKH 2834
Query: 410 HVCDGMKDCPRGDDEE-RCPLKRKCSAEEKC 439
VCD +DC G DE C +E +C
Sbjct: 2835 FVCDHDRDCADGSDESPECEYPTCGPSEFRC 2865
Score = 118 bits (283), Expect = 3e-25
Identities = 64/183 (34%), Positives = 95/183 (51%), Gaps = 22/183 (12%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKC-NDGKCIPER 320
+C F+C C F CDGDNDC D +DE +C + C +FKC N +CIP
Sbjct: 3373 KCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDI--HVCLPSQFKCTNTNRCIPGI 3430
Query: 321 WRCDNERDCADGGDELNCKPNSIRNCSLDEYTCA-DRRCVLKTWLCDGVRDCTNGEDE-M 378
+RC+ + +C DG DE +C P C+ +++ C+ +RC+ + W+CD DC +G DE
Sbjct: 3431 FRCNGQDNCGDGEDERDC-PEV--TCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPA 3487
Query: 379 NC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE 437
NC +++C D++ C+ C+ + CDG DC G DE K +C E
Sbjct: 3488 NCTQMTCGVDEFRCKDS--------GRCIPARWKCDGEDDCGDGSDEP----KEECD-ER 3534
Query: 438 KCE 440
CE
Sbjct: 3535 TCE 3537
Score = 111 bits (268), Expect = 2e-23
Identities = 86/319 (26%), Positives = 144/319 (45%), Gaps = 30/319 (9%)
Query: 482 CSQTCS-NTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSV 540
C Q C G C C G +L D SC+ + LL+S R ++ + L+ + ++
Sbjct: 2166 CQQLCLYRGRGQRACACAHG-MLAEDGASCREY--AGYLLYSERTILKSIHLSDERNLNA 2222
Query: 541 V-------KGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSD------VIRWGL 587
+ + N +AL + Y + N + + N + ++D I +
Sbjct: 2223 PVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIVENV 2282
Query: 588 ETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSK------RAVLVANDLDKPRAIAVHPG 641
+ G+A D L+WT T + T+D ++ V+ + D PRA +
Sbjct: 2283 GSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDEC 2342
Query: 642 DALVFWTDWGP-NPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIE 700
L+FWT+W +P I RA + G T+I +I PNGL ID+ K+Y++DA IE
Sbjct: 2343 QNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIE 2402
Query: 701 RAAFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGL-N 759
R +DG R + HPF L ++ + I+WTDW +++ NK+ G ++ + +
Sbjct: 2403 RCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQ 2462
Query: 760 VPMDI-----HSRSCEETP 773
PM I + SCE +P
Sbjct: 2463 QPMGIIAVANDTNSCELSP 2481
Score = 104 bits (250), Expect = 3e-21
Identities = 68/236 (28%), Positives = 99/236 (41%), Gaps = 24/236 (10%)
Query: 264 AEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRC 323
A+ +FEC N +C+ CDG C D +DE C +C++G+C+ C
Sbjct: 2526 AQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWC 2585
Query: 324 DNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVS 383
+ DC DG DE+ C + C + E+ C D C+ + C+ DC + DEMNC +
Sbjct: 2586 NGADDCGDGSDEIPCNKTA---CGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSAT 2642
Query: 384 CEEDQYTCRPQEHLMSNAFRN--CVNRKHVCDGMKDCPRGDDEERCP-LKRKCSAEEKCE 440
+ + L R C VCDG DC DE CP +KR
Sbjct: 2643 DCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKR--------- 2693
Query: 441 KLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV-CSQTCSNTVGSFRC 495
C Y ACP G + ++C D+C + +D C++ CS F C
Sbjct: 2694 PRCPLNY-----FACPSGRCIPM-SWTCDKEDDCEHGEDETHCNKFCSE--AQFEC 2741
Score = 104 bits (249), Expect = 3e-21
Identities = 65/196 (33%), Positives = 91/196 (46%), Gaps = 24/196 (12%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
RC + +C N +CV C+G +DCGD +DE C +C GEF+C DG CI
Sbjct: 2565 RCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKT--ACGVGEFRCRDGTCIGNSS 2622
Query: 322 RCDNERDCADGGDELNCKPNSIRNCS----------LDEYTCADRRCVLKTWLCDGVRDC 371
RC+ DC D DE+NC S +CS L + C +W+CDG DC
Sbjct: 2623 RCNQFVDCEDASDEMNC---SATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDC 2679
Query: 372 TNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKR 431
+ DE +C + C P + + R C+ CD DC G+DE C +
Sbjct: 2680 GDYSDERDCP---GVKRPRC-PLNYFACPSGR-CIPMSWTCDKEDDCEHGEDETHC--NK 2732
Query: 432 KCS-AEEKCEK-LCIT 445
CS A+ +C+ CI+
Sbjct: 2733 FCSEAQFECQNHRCIS 2748
Score = 101 bits (242), Expect = 2e-20
Identities = 49/128 (38%), Positives = 60/128 (46%), Gaps = 8/128 (6%)
Query: 301 PGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVL 360
P C GEF C + +CI ERW+CD + DC D DE + C D + C + RC+
Sbjct: 851 PPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQ-HTCPSDRFKCENNRCIP 909
Query: 361 KTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDC-P 419
WLCDG DC N EDE N S TC P + S A C+ CD DC
Sbjct: 910 NRWLCDGDNDCGNSEDESNATCSAR----TCPPNQ--FSCASGRCIPISWTCDLDDDCGD 963
Query: 420 RGDDEERC 427
R D+ C
Sbjct: 964 RSDESASC 971
Score = 93.5 bits (222), Expect = 6e-18
Identities = 77/288 (26%), Positives = 126/288 (43%), Gaps = 16/288 (5%)
Query: 1025 GCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPY---LI 1081
GCS C G C C G +L DG+TCAD ++ R I+ Y +
Sbjct: 2951 GCSQDCEDLKIGFKCRCRPGFRLKDDGRTCAD--VDECSTTFPCSQRCINTHGSYKCLCV 3008
Query: 1082 DVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVI 1141
+ P ++ D LI+ R R L T++ GL+ A +
Sbjct: 3009 EGYAPRGGDPHSCKAVTDEEPFLIF----ANRYYLRKLNLDGSNYTLLKQGLNNAVALDF 3064
Query: 1142 DSTGRKIYWTD--GGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTS 1199
D + IYWTD + I L+G N +VL TGL +P +A+ + G ++W D G
Sbjct: 3065 DYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRD 3124
Query: 1200 AKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFDGHDRRTV 1258
IE + ++G R V+V + ++ P L +D G LYW D I DG R +
Sbjct: 3125 T-IEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVI 3183
Query: 1259 L-SNVPYPYGIVI--VGQHIYWTDWKTKALHRADKTNASDPIVIRKNL 1303
+ + + +P G+ + V + IYW D + + A ++ +V+ +++
Sbjct: 3184 VDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDI 3231
Score = 92.7 bits (220), Expect = 1e-17
Identities = 54/188 (28%), Positives = 83/188 (44%), Gaps = 27/188 (14%)
Query: 303 SCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKT 362
+C A +F C + KCIP W+CD E DC D DE P C ++ C+ C
Sbjct: 3333 NCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEF--KCRPGQFQCSTGICTNPA 3390
Query: 363 WLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGD 422
++CDG DC + DE NC++ + C P + +N R C+ C+G +C G+
Sbjct: 3391 FICDGDNDCQDNSDEANCDI------HVCLPSQFKCTNTNR-CIPGIFRCNGQDNCGDGE 3443
Query: 423 DEERC------PLKRKCSAEEKC---------EKLCITTYDGHAACACPMGFLLAEDKYS 467
DE C P + +CS ++C + C+ D A C D++
Sbjct: 3444 DERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCT---QMTCGVDEFR 3500
Query: 468 CRDIDECM 475
C+D C+
Sbjct: 3501 CKDSGRCI 3508
Score = 91.1 bits (216), Expect = 3e-17
Identities = 79/296 (26%), Positives = 140/296 (47%), Gaps = 21/296 (7%)
Query: 1019 CGKNNGGCSHLCLLKPG-GRSCACPIGIKLNKDGKTC--ADGPINYLIFAHRVDIRVISL 1075
C NNGGCSH C + PG G C+CP+G++L D TC +L + + D S+
Sbjct: 1185 CSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSV 1244
Query: 1076 DVPYLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHT 1135
VL P ++ +D +I+ + + +I+R L +V+ GL
Sbjct: 1245 KCSCYEGWVLE-PDGESCRSLD-PFKPFIIF---SNRHEIRRID-LHKGDYSVLVPGLRN 1298
Query: 1136 ADGIVIDSTGRKIYWTDGGRNSIEVAEL--DG--RNRKVLVWTGLDSPRAIALHYEYGYM 1191
+ + +YWTD + I +L +G + +V++ GL +P +A+ + G +
Sbjct: 1299 TIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNI 1358
Query: 1192 FWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWN--DAKILTIESSD 1249
+W + +IE A +DG R ++ I+ P +A+D +G L+W DA + IE++
Sbjct: 1359 YWVE-SNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAAS 1417
Query: 1250 FDGHDRRTV---LSNVPYPYGIVI--VGQHIYWTDWKTKALHRADKTNASDPIVIR 1300
G RRTV + +P G+ + + + I W D ++ A++ A + V+R
Sbjct: 1418 MSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLR 1473
Score = 87.8 bits (208), Expect = 3e-16
Identities = 71/261 (27%), Positives = 112/261 (42%), Gaps = 24/261 (9%)
Query: 91 KAIDVIHTDPDDGPLNEGTEDDAGCITP-CLKIN-FSCQISCTCIPMEKRXXXXXXXXXX 148
+ I + T D + +++ A C P C + F+C + CI + R
Sbjct: 947 RCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCN-NGRCININWRCDNDNDCGDN 1005
Query: 149 XXXXXXXRSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSAN 208
SC + + C+S CI W CDGDNDCGD+SDE + + + P
Sbjct: 1006 SDEAGCSHSCSSTQFK--CNSGR-CIPEHWTCDGDNDCGDYSDETHANCTNQATRPP--- 1059
Query: 209 ASLNIGDVITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDF 268
G T+ L + +R+ +D +++ +S + V + + F
Sbjct: 1060 -----GGCHTD-EFQCRLDGLCIPLRWRCDGDTDCMD-SSDEKSC--EGVTHVCDPSVKF 1110
Query: 269 ECKNT-KCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKC--NDGKCIPERWRCDN 325
CK++ +C+ K + CDGDNDC D +DE++C + +C C N C+P CD
Sbjct: 1111 GCKDSARCISKAWVCDGDNDCEDNSDEENCESL--ACRPPSHPCANNTSVCLPPDKLCDG 1168
Query: 326 ERDCADGGDELN-CKPNSIRN 345
DC DG DE C S+ N
Sbjct: 1169 NDDCGDGSDEGELCDQCSLNN 1189
Score = 83.4 bits (197), Expect = 7e-15
Identities = 70/266 (26%), Positives = 122/266 (45%), Gaps = 18/266 (6%)
Query: 685 TESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLF--DDAIYWTDWHTKS--I 740
T+ + + A + + + DG + + +GL + AL + IYWTD T+ I
Sbjct: 3025 TDEEPFLIFANRYYLRKLNLDGSNYT-LLKQGLNNAVALDFDYREQMIYWTDVTTQGSMI 3083
Query: 741 STVNKNTGMGIQTVH-AGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESKKPIDSL 799
++ N G +Q +H GL+ P + + + L + +D +E K +
Sbjct: 3084 RRMHLN-GSNVQVLHRTGLSNPDGL---AVDWVGGNLYWCDKGRDT----IEVSKLNGAY 3135
Query: 800 DMVIPVETIKSAVALDWDQKSNSIFWTDV-EKDTINRAYLNGSHQTTIVDSNLIWPAGLA 858
V+ ++ AL D ++ ++WTD + I R ++GS ++ IVD+ + WP GL
Sbjct: 3136 RTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLT 3195
Query: 859 FDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASP 918
D++T++IYW D + IE + DGS R ++ I P + +YW+DW +
Sbjct: 3196 LDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDI--PHIFALTLFEDYVYWTDW-ETK 3252
Query: 919 CIERADMDGGNRKKLIFGQMTWPNGL 944
I RA G K L+ + P L
Sbjct: 3253 SINRAHKTTGTNKTLLISTLHRPMDL 3278
Score = 78.6 bits (185), Expect = 2e-13
Identities = 72/271 (26%), Positives = 104/271 (38%), Gaps = 28/271 (10%)
Query: 107 EGTEDDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTI 166
E ED+ C C + F CQ + CI + +
Sbjct: 2722 EHGEDETHCNKFCSEAQFECQ-NHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFS 2780
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIAL 226
C T+VC+ WLCDGD DC D +DE + L N++ + + + I
Sbjct: 2781 CPGTHVCVPERWLCDGDKDCADGADE---SIAAGCLY----NSTCDDREFMCQNRQCI-- 2831
Query: 227 TKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCV-PKDFQCDGD 285
V ++ CA + D + P E RCA N +C+ + ++CDG+
Sbjct: 2832 -PKHFVCDHDRDCADGS-DESPECEYPTCGPSE-FRCA-------NGRCLSSRQWECDGE 2881
Query: 286 NDCGDWTDE----DSCPMVPGSCNA-GEFKCNDGKCIPERWRCDNERDCADGGDELNCKP 340
NDC D +DE C CNA +F C+ G+C+ E C+ + DC D DE C
Sbjct: 2882 NDCHDQSDEAPKNPHCTSPEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHI 2941
Query: 341 NSI--RNCSLDEYTCADRRCVLKTWLCDGVR 369
N R S C D + K G R
Sbjct: 2942 NECLSRKLSGCSQDCEDLKIGFKCRCRPGFR 2972
Score = 74.9 bits (176), Expect = 2e-12
Identities = 75/267 (28%), Positives = 108/267 (40%), Gaps = 34/267 (12%)
Query: 102 DGPLNEGTEDDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEH 161
D + +++++ PC + FSC + CI + CD
Sbjct: 3558 DNDCGDNSDEESCTPRPCSESEFSCA-NGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMD 3616
Query: 162 ENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDV-VKTSLLVPSANASLNIGDVITNP 220
+ + C S + CI L W CD D DC D SDE C V+T L + N
Sbjct: 3617 QFQ--CKSGH-CIPLRWRCDADADCMDGSDEEACGTGVRTCPL----------DEFQCNN 3663
Query: 221 TVLIALTKPTV-VIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTK-CVPK 278
T L KP E C + +N P RC KN + C+
Sbjct: 3664 T----LCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRC-------KNDRVCLWI 3712
Query: 279 DFQCDGDNDCGDWTDEDSC-PMVPGS--C-NAGEFKCNDGKCIPERWRCDNERDCADGGD 334
QCDG ++CGD TDE+ C P + C + EF C + +C+ RC+ DC DG D
Sbjct: 3713 GRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSD 3772
Query: 335 ELNCKPN-SIRNCSLDEYTCADR-RCV 359
E +C + + +C+ + C D RCV
Sbjct: 3773 EEDCSIDPKLTSCATNASICGDEARCV 3799
Score = 70.1 bits (164), Expect = 7e-11
Identities = 72/284 (25%), Positives = 122/284 (42%), Gaps = 24/284 (8%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRD-IDECMYEQDPVC-------SQTCSNTV 490
C++LC+ G ACAC G +LAED SCR+ +Y + + + + V
Sbjct: 2166 CQQLCLYRGRGQRACACAHG-MLAEDGASCREYAGYLLYSERTILKSIHLSDERNLNAPV 2224
Query: 491 GSFR-CGCMTGYI-LRPDERSCKPTGESPTLLFSN-RIG-IRQVWLTGDNYMSVVKGLHN 546
F M I L D R+ G + FS+ G I+Q+ G +++V+ + +
Sbjct: 2225 QPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIVENVGS 2284
Query: 547 AVALDYHYEKKLVFWSENNLRVI---RVAQMNT---KNMSDVIRWGLETPAGVAVDWIHD 600
L YH ++W+ I V Q + + + G + P +D +
Sbjct: 2285 VEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQN 2344
Query: 601 LLFWTDSGTRRVEV--ATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIER 658
L+FWT+ + + A L G+ L+ D+ P +A+ ++++D KIER
Sbjct: 2345 LMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSD-ATLDKIER 2403
Query: 659 ADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERA 702
+ DG R ++ E P GL + Y E I+W D ++RA
Sbjct: 2404 CEYDGSHRYVILKSEPVHPFGLAV-YGE-HIFWTDWVRRAVQRA 2445
Score = 64.1 bits (149), Expect = 4e-09
Identities = 73/260 (28%), Positives = 113/260 (43%), Gaps = 25/260 (9%)
Query: 1315 ERVLENACGTDNGGCSHLCLRSP-LGYTCACPTGMPF-EKSTTDQTPKKCKSHPEEFLIF 1372
E L + C +NGGCSH C +P G C+CP GM + T Q C H L
Sbjct: 1178 EGELCDQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKH----LKC 1233
Query: 1373 ATRGSITYISLESP--EQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTN 1430
+ + S++ E W V P E ++ D F + + IR I++
Sbjct: 1234 SQKCDQNKFSVKCSCYEGW-VLEPDGESCRSL------DPFKPFIIFSNRHEIRRIDLHK 1286
Query: 1431 MSESKTIISQKLETPNGLGVDWIANNIYWTD-NEHKVIEVARLDG---SSRKVLIT-GLT 1485
S ++ L L + +YWTD E K+ LD +S +V+I GL
Sbjct: 1287 GDYS--VLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLA 1344
Query: 1486 EPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYW 1545
P LA+ G +YW + IE + LDG+ R ++ D+ P + +D ++ L+W
Sbjct: 1345 TPEGLAVDWIAGNIYWVE-SNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFW 1403
Query: 1546 T--DALKDRIDTSDLNGQHR 1563
T DA RI+ + ++G R
Sbjct: 1404 TDWDASLPRIEAASMSGAGR 1423
Score = 60.9 bits (141), Expect = 4e-08
Identities = 61/229 (26%), Positives = 95/229 (41%), Gaps = 16/229 (6%)
Query: 680 LTIDYTESKIYWADA--KHHVIERAAFDGRDRRKVTTKGLPHPFALTL--FDDAIYWTDW 735
L DY E IYW D + +I R +G + + + GL +P L + +YW D
Sbjct: 3062 LDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDK 3121
Query: 736 HTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESKKP 795
+I N V +GL P R+ + LY D L +
Sbjct: 3122 GRDTIEVSKLNGAYRTVLVSSGLREP-----RALVVDVQNGYLYWT--DWGDHSLIGRIG 3174
Query: 796 IDSLDMVIPVET-IKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWP 854
+D + V+T I L D + I+W D +D I A L+GS++ ++ ++ P
Sbjct: 3175 MDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDI--P 3232
Query: 855 AGLAFDWITDKIYWTDGGTNRI-EVSKSDGSMRTLLAWDHIDKPRDIVV 902
A D +YWTD T I K+ G+ +TLL + +P D+ V
Sbjct: 3233 HIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLI-STLHRPMDLHV 3280
Score = 59.3 bits (137), Expect = 1e-07
Identities = 29/97 (29%), Positives = 43/97 (44%), Gaps = 7/97 (7%)
Query: 343 IRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAF 402
+ NC+ ++ C + +C+ W CD DC + DE C E + CRP + S
Sbjct: 3331 VSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDE---PPDCPE--FKCRPGQFQCSTGI 3385
Query: 403 RNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKC 439
C N +CDG DC DE C + ++ KC
Sbjct: 3386 --CTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKC 3420
Score = 56.4 bits (130), Expect = 9e-07
Identities = 27/78 (34%), Positives = 39/78 (50%), Gaps = 5/78 (6%)
Query: 263 CAEIDFECKNT-KCVPKDFQCDGDNDCGDWTDE--DSCPMVPGS-CNAGEFKC-NDGKCI 317
C+ F C++ C+ K ++CDG+ DC D +DE + CP C E C C+
Sbjct: 27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCV 86
Query: 318 PERWRCDNERDCADGGDE 335
P C+ +DC DG DE
Sbjct: 87 PMSRLCNGVQDCMDGSDE 104
Score = 51.6 bits (118), Expect = 2e-05
Identities = 19/33 (57%), Positives = 24/33 (72%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCDVVK 199
C T++C A W+CDG NDCGD+SDE +C VK
Sbjct: 2660 CERTSLCYAPSWVCDGANDCGDYSDERDCPGVK 2692
Score = 49.6 bits (113), Expect = 1e-04
Identities = 44/157 (28%), Positives = 64/157 (40%), Gaps = 16/157 (10%)
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGG---DELNCKPNSIRNCSLD 349
D +SC + P N G C D + + + C G D+L C+ + + D
Sbjct: 2473 DTNSCELSPCRINNGG--CQDLCLLTHQGHVNCS--CRGGRILQDDLTCRAVNSSCRAQD 2528
Query: 350 EYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRK 409
E+ CA+ C+ + CDGV C + DE + C+ SN CV+
Sbjct: 2529 EFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRR----CKKTFRQCSNG--RCVSNM 2582
Query: 410 HVCDGMKDCPRGDDEERCPLKRKCSAEE-KC-EKLCI 444
C+G DC G DE C K C E +C + CI
Sbjct: 2583 LWCNGADDCGDGSDEIPCN-KTACGVGEFRCRDGTCI 2618
Score = 44.8 bits (101), Expect = 0.003
Identities = 33/94 (35%), Positives = 38/94 (40%), Gaps = 9/94 (9%)
Query: 107 EGTEDDAGC-ITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDE---HE 162
+ D+A C I CL F C + CIP R R C E
Sbjct: 3400 QDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDE----RDCPEVTCAP 3455
Query: 163 NRTICHSTNVCIALEWLCDGDNDCGDFSDE-INC 195
N+ C T CI W+CD DNDC D SDE NC
Sbjct: 3456 NQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANC 3489
Score = 42.3 bits (95), Expect = 0.015
Identities = 27/86 (31%), Positives = 33/86 (38%), Gaps = 5/86 (5%)
Query: 110 EDDAGCI-TPCLKINFSCQISCTCIPMEK--RXXXXXXXXXXXXXXXXXRSCDEHENRTI 166
ED+ C C F C I+ CIP +C E R
Sbjct: 3443 EDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFR-- 3500
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDE 192
C + CI W CDG++DCGD SDE
Sbjct: 3501 CKDSGRCIPARWKCDGEDDCGDGSDE 3526
Score = 38.3 bits (85), Expect = 0.25
Identities = 18/58 (31%), Positives = 28/58 (48%), Gaps = 1/58 (1%)
Query: 422 DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQD 479
+D C L C+ LC+ T+ GH C+C G +L +D +CR ++ QD
Sbjct: 2472 NDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRIL-QDDLTCRAVNSSCRAQD 2528
Score = 36.3 bits (80), Expect = 1.00
Identities = 14/20 (70%), Positives = 14/20 (70%)
Query: 173 CIALEWLCDGDNDCGDFSDE 192
CI W CDGDNDC D SDE
Sbjct: 866 CIQERWKCDGDNDCLDNSDE 885
Score = 35.5 bits (78), Expect = 1.7
Identities = 13/26 (50%), Positives = 15/26 (57%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDE 192
C CI+ W CDG+ DC D SDE
Sbjct: 34 CRDQITCISKGWRCDGERDCPDGSDE 59
Score = 33.1 bits (72), Expect = 9.3
Identities = 38/152 (25%), Positives = 61/152 (40%), Gaps = 23/152 (15%)
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCT-NGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRN 404
C ++ C D C+L G +C+ G + +++C +CR Q+ A
Sbjct: 2482 CRINNGGCQDL-CLLTH---QGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFEC-ANGE 2536
Query: 405 CVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAED 464
C+N CDG+ C DE+ C++ +C+K +G C L
Sbjct: 2537 CINFSLTCDGVPHCKDKSDEK----PSYCNSR-RCKKTFRQCSNGR----CVSNMLW--- 2584
Query: 465 KYSCRDIDECMYEQDPV-CSQTCSNTVGSFRC 495
C D+C D + C++T VG FRC
Sbjct: 2585 ---CNGADDCGDGSDEIPCNKTACG-VGEFRC 2612
>DQ314873-1|ABC40732.1| 4544|Homo sapiens low density
lipoprotein-related protein 1 (alpha-2-macroglobulin
receptor) protein.
Length = 4544
Score = 549 bits (1355), Expect = e-155
Identities = 318/908 (35%), Positives = 492/908 (54%), Gaps = 67/908 (7%)
Query: 800 DMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYL--NGSHQT--TIVDSNLIWPA 855
D + V +++ +ALD+ ++++WTDV +D I R L NG+ + ++ L P
Sbjct: 1288 DYSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPE 1347
Query: 856 GLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWG 915
GLA DWI IYW + ++IEV+K DG++RT L I+ PR I ++P G+++W+DW
Sbjct: 1348 GLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWD 1407
Query: 916 AS-PCIERADMDGGNRKKL--IFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTG 972
AS P IE A M G R+ + G WPNGL +D + RI W D + I A DG+G
Sbjct: 1408 ASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSG 1467
Query: 973 RTKLI---ENLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTG------------------ 1011
+++ E L HPF + LYG EV+WTDW T ++ ANK TG
Sbjct: 1468 HMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQV 1527
Query: 1012 --AKRRTLG---CGKN--NGGCSHLCLLKPGGR-SCACPIGIKLNKDGKTCADGPINYLI 1063
R+ + C N G CSHLCL+ SCACP +KL+KD TC + +L+
Sbjct: 1528 YHPSRQPMAPNPCEANGGQGPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYEFK-KFLL 1586
Query: 1064 FAHRVDIRVISLDVPYLIDVV-LPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLG 1122
+A +++IR + LD PY ++ +P + N +D D +YW+D + I+RA G
Sbjct: 1587 YARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFING 1646
Query: 1123 THVETVIGNGLHTADGIVIDSTGRKIYWT--DGGRNSIEVAELDGRNRKVLVWTGLDSPR 1180
T VETV+ L A G+ +D R ++WT D + I VA LDG + +V GL+ P
Sbjct: 1647 TGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPH 1705
Query: 1181 AIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDA 1240
+ +H G ++W+D I A+MDG+NR ++ + K P GLAID E +LYW +
Sbjct: 1706 GLVVHPLRGKLYWTD---GDNISMANMDGSNRTLLFSGQ-KGPVGLAIDFPESKLYWISS 1761
Query: 1241 KILTIESSDFDGHDRRTV---LSNVPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPI 1297
TI + DG + S + + I+G ++W D ++ + K + S +
Sbjct: 1762 GNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSV 1821
Query: 1298 VIRKNLEGLMDIR----AIQSERVLENACGTDNGGCSHLCL-RSPLGYTCACPTGMPFEK 1352
V+R + +M ++ +IQ + N C +NG CS LCL S +C C G
Sbjct: 1822 VLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRS 1881
Query: 1353 STTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDYHWDLKM 1412
+ C+ FL+++ I I L+ ++ D +PV + +D+H +
Sbjct: 1882 G-----QQACEG-VGSFLLYSVHEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDT 1935
Query: 1413 IFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARL 1472
I++ D+ L+ I S + + + +++ + G+ VDWIA NIYWTD VIEVARL
Sbjct: 1936 IYWVDMGLSTI-SRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARL 1994
Query: 1473 DGSSRKVLIT-GLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFP 1531
+GS R V+I+ GL +PRA+ + P KGYL+W++WG++P IERS LDG++R ++V V + +P
Sbjct: 1995 NGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWP 2054
Query: 1532 NGLTIDYKERRLYWTDALKDRIDTSDL-NGQHR-VQLVPDAKNPFGMTQFKDYIYWTD-- 1587
NG+++DY++ +LYW DA D+I+ DL G++R V L + + F ++ F+D+IYW+D
Sbjct: 2055 NGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRT 2114
Query: 1588 WYKKSIIRADKRTGKNITLIRTNLEMAM-EIKAVSADRQHGWNPCKESNGGCSHLCLFRG 1646
SI R K + +RT + + + +IK + DRQ G N C +NGGC LCL+RG
Sbjct: 2115 HANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRG 2174
Query: 1647 H-EYICAC 1653
+ CAC
Sbjct: 2175 RGQRACAC 2182
Score = 522 bits (1288), Expect = e-147
Identities = 358/1174 (30%), Positives = 579/1174 (49%), Gaps = 105/1174 (8%)
Query: 559 VFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTD--SGTRRVEVAT 616
++W E+NL I VA+++ + ++ +E P +A+D +LFWTD + R+E A+
Sbjct: 1358 IYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAAS 1417
Query: 617 LDGSKRAVL--VANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEI 674
+ G+ R + P + V + + W D + I A DG V+
Sbjct: 1418 MSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWID-ARSDAIYSARYDGSGHMEVLRGHE 1476
Query: 675 FWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYWTD 734
F + + ++YW D + + + +A V + PF L +Y
Sbjct: 1477 FLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQ-----VYHPS 1531
Query: 735 WHTKSISTVNKNTGMGI----------QTVHAGLNVPMDIH--SRSCEETPEKLLLYARR 782
+ + N G G +TV M +H + +C E +K LLYAR+
Sbjct: 1532 RQPMAPNPCEANGGQGPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYEF-KKFLLYARQ 1590
Query: 783 KDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSH 842
++R L++ P + + V I + LD+D + ++W+DV I RA++NG+
Sbjct: 1591 MEIRGVDLDA--PYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTG 1648
Query: 843 QTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNR--IEVSKSDGSMRTLLAWDHIDKPRDI 900
T+V ++L GLA DW++ ++WT TN+ I V++ DGS + + +++P +
Sbjct: 1649 VETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPHGL 1707
Query: 901 VVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGN 960
VV+P G +YW+D I A+MDG NR L GQ P GLA+D +++YW GN
Sbjct: 1708 VVHPLRGKLYWTD---GDNISMANMDGSNRTLLFSGQKG-PVGLAIDFPESKLYWISSGN 1763
Query: 961 KTIEYANLDGTGRTKLIENLPHPFG----LDLYGDEVFWTDWDTQSIQAANKDTGA---- 1012
TI NLDG+G ++I+ + G L + GD+++W D ++ + +K G+
Sbjct: 1764 HTINRCNLDGSG-LEVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVV 1822
Query: 1013 ---------------------KRRTLGCGKNNGGCSHLCL-LKPGGRSCACPIGIKLNKD 1050
+ T C NNG CS LCL RSC C G L +
Sbjct: 1823 LRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSL-RS 1881
Query: 1051 GKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNALGVDVDHSTGLIYWTDT 1110
G+ +G ++L+++ IR I LD D ++P+ A+G+D IYW D
Sbjct: 1882 GQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDM 1941
Query: 1111 GQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKV 1170
G I RA R T E V+ NG+ +GI +D IYWTD G + IEVA L+G R V
Sbjct: 1942 GLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYV 2001
Query: 1171 LVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDR 1230
++ GLD PRAI +H E GY+FW++WG +IER+ +DG R V+V+ I WPNG+++D
Sbjct: 2002 VISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWPNGISVDY 2061
Query: 1231 IEGRLYWNDAKILTIESSDFD-GHDRRTVL-SNVPYPYGIVIVGQHIYWTDWKTKA---L 1285
+G+LYW DA+ IE D + G +R VL SN + + + IYW+D +T A +
Sbjct: 2062 QDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSD-RTHANGSI 2120
Query: 1286 HRADKTNASDPIVIRKNL-EGLMDIRAIQSERVL-ENACGTDNGGCSHLCLRSPLGY-TC 1342
R K NA+D + +R + L DI+ +R N C NGGC LCL G C
Sbjct: 2121 KRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGRGQRAC 2180
Query: 1343 ACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTL-PVKE---V 1398
AC GM E + C+ + +L+++ R + I L + + P ++ +
Sbjct: 2181 ACAHGMLAEDGAS------CREY-AGYLLYSERTILKSIHLSDERNLNAPVQPFEDPEHM 2233
Query: 1399 KNTIAVDYHWDL-------KMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVD 1451
KN IA+ + + IF++D+ I+ IN + S TI+ + + + GL
Sbjct: 2234 KNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQIN-DDGSRRITIV-ENVGSVEGLAYH 2291
Query: 1452 WIANNIYWTDN-----EHKVIEVARLDGSSRKVLIT--GLTEPRALALFPAKGYLYWSDW 1504
+ +YWT ++ R R+ +IT G PRA L + ++W++W
Sbjct: 2292 RGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNW 2351
Query: 1505 GE-HPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHR 1563
E HP I R+ L G+ +++ D+ PNGL ID++ +LY++DA D+I+ + +G HR
Sbjct: 2352 NEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHR 2411
Query: 1564 -VQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNL-EMAMEIKAVS 1621
V L + +PFG+ + ++I+WTDW ++++ RA+K G N+ L+R ++ + M I AV+
Sbjct: 2412 YVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVA 2471
Query: 1622 ADRQH-GWNPCKESNGGCSHLCLFRGHEYI-CAC 1653
D +PC+ +NGGC LCL ++ C+C
Sbjct: 2472 NDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSC 2505
Score = 406 bits (999), Expect = e-112
Identities = 203/513 (39%), Positives = 291/513 (56%), Gaps = 17/513 (3%)
Query: 263 CAEIDFECKNTK-CVPKDFQCDGDNDCGDWTDEDSCP--MVPGSCNAGEFKCNDGKCIPE 319
C F C T CVP+ + CDGD DC D DE + +C+ EF C + +CIP+
Sbjct: 2774 CGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQNRQCIPK 2833
Query: 320 RWRCDNERDCADGGDEL-NCKPNSIRNCSLDEYTCADRRCVL-KTWLCDGVRDCTNGEDE 377
+ CD++RDCADG DE C+ C E+ CA+ RC+ + W CDG DC + DE
Sbjct: 2834 HFVCDHDRDCADGSDESPECE---YPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDE 2890
Query: 378 MNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAE- 436
C ++ C + ++ R CV +C+G DC DE C + S +
Sbjct: 2891 APKNPHCTSPEHKCNASSQFLCSSGR-CVAEALLCNGQDDCGDSSDERGCHINECLSRKL 2949
Query: 437 EKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCG 496
C + C G C C GF L +D +C D+DEC CSQ C NT GS++C
Sbjct: 2950 SGCSQDCEDLKIGFK-CRCRPGFRLKDDGRTCADVDECSTTFP--CSQRCINTHGSYKCL 3006
Query: 497 CMTGYILRP-DERSCKP-TGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHY 554
C+ GY R D SCK T E P L+F+NR +R++ L G NY + +GL+NAVALD+ Y
Sbjct: 3007 CVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDY 3066
Query: 555 EKKLVFWSENNLR--VIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRV 612
+++++W++ + +IR +N N+ + R GL P G+AVDW+ L+W D G +
Sbjct: 3067 REQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTI 3126
Query: 613 EVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYD 672
EV+ L+G+ R VLV++ L +PRA+ V + ++WTDWG + I R MDG R ++
Sbjct: 3127 EVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDT 3186
Query: 673 EIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYW 732
+I WPNGLT+DY +IYWADA+ IE A+ DG +R V ++ +PH FALTLF+D +YW
Sbjct: 3187 KITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYW 3246
Query: 733 TDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIH 765
TDW TKSI+ +K TG + + L+ PMD+H
Sbjct: 3247 TDWETKSINRAHKTTGTNKTLLISTLHRPMDLH 3279
Score = 386 bits (951), Expect = e-106
Identities = 197/522 (37%), Positives = 283/522 (54%), Gaps = 31/522 (5%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDE------DSCPMVPGSCNAGEFKCN-DGK 315
C+ F+C + +C+P+ + CDGDNDCGD++DE + PG C+ EF+C DG
Sbjct: 1015 CSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGL 1074
Query: 316 CIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADR-RCVLKTWLCDGVRDCTNG 374
CIP RWRCD + DC D DE +C+ + ++ C D RC+ K W+CDG DC +
Sbjct: 1075 CIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDN 1134
Query: 375 EDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE-ERCPLKRKC 433
DE NCE CRP H +N C+ +CDG DC G DE E C +C
Sbjct: 1135 SDEENCE------SLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCD---QC 1185
Query: 434 SAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGS 492
S C C C+CP+G L D ++C+ C CSQ C S
Sbjct: 1186 SLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLK--CSQKCDQNKFS 1243
Query: 493 FRCGCMTGYILRPDERSCKPTGE-SPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALD 551
+C C G++L PD SC+ P ++FSNR IR++ L +Y +V GL N +ALD
Sbjct: 1244 VKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALD 1303
Query: 552 YHYEKKLVFWSEN-NLRVIRVAQMNTKNMSD---VIRWGLETPAGVAVDWIHDLLFWTDS 607
+H + ++W++ ++ R ++ ++ VI++GL TP G+AVDWI ++W +S
Sbjct: 1304 FHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVES 1363
Query: 608 GTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPN-PKIERADMDGDKR 666
++EVA LDG+ R L+A D++ PRAIA+ P D ++FWTDW + P+IE A M G R
Sbjct: 1364 NLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGR 1423
Query: 667 KTVIYD--EIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTT--KGLPHPFA 722
+TV + WPNGLT+DY E +I W DA+ I A +DG +V + L HPFA
Sbjct: 1424 RTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFA 1483
Query: 723 LTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDI 764
+TL+ +YWTDW T +++ NK TG + V P D+
Sbjct: 1484 VTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDL 1525
Score = 330 bits (810), Expect = 4e-89
Identities = 207/645 (32%), Positives = 325/645 (50%), Gaps = 42/645 (6%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTCAD-GPIN-YLIFAHRVDIRVISLDVPYLIDV 1083
CS C C+C G L DG++C P ++IF++R +IR I L + D
Sbjct: 1233 CSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDL---HKGDY 1289
Query: 1084 VLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLG----THVETVIGNGLHTADGI 1139
+ +P L+N + +D S +YWTD + KI R L T E VI GL T +G+
Sbjct: 1290 SVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGL 1349
Query: 1140 VIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTS 1199
+D IYW + + IEVA+LDG R L+ ++ PRAIAL G +FW+DW S
Sbjct: 1350 AVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDAS 1409
Query: 1200 -AKIERADMDGNNRRVI--VDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRR 1256
+IE A M G RR + WPNGL +D +E R+ W DA+ I S+ +DG
Sbjct: 1410 LPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHM 1469
Query: 1257 TVLSN---VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQ 1313
VL + +P+ + + G +YWTDW+T L +A+K + V+++ D++
Sbjct: 1470 EVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYH 1529
Query: 1314 SER--VLENACGTD--NGGCSHLCL-RSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEE 1368
R + N C + G CSHLCL +CACP M K T C ++
Sbjct: 1530 PSRQPMAPNPCEANGGQGPCSHLCLINYNRTVSCACPHLMKLHKDNT-----TCYEF-KK 1583
Query: 1369 FLIFATRGSITYISLESP-EQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSIN 1427
FL++A + I + L++P + ++ V ++ N +DY + ++++D+ I+
Sbjct: 1584 FLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRA- 1642
Query: 1428 MTNMSESKTIISQKLETPNGLGVDWIANNIYWT--DNEHKVIEVARLDGSSRKVLITGLT 1485
N + +T++S L +GL VDW++ N++WT D K I VARLDGS + ++ GL
Sbjct: 1643 FINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVVQGLE 1702
Query: 1486 EPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYW 1545
+P L + P +G LYW+D G++ I + +DGS R ++ G P GL ID+ E +LYW
Sbjct: 1703 QPHGLVVHPLRGKLYWTD-GDN--ISMANMDGSNRTLLFSGQKG-PVGLAIDFPESKLYW 1758
Query: 1546 TDALKDRIDTSDLNGQHRVQLVPDAKNPFG----MTQFKDYIYWTDWYKKSIIRADKRTG 1601
+ I+ +L+G ++++ ++ G + D ++W D + + K G
Sbjct: 1759 ISSGNHTINRCNLDGS-GLEVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADG 1817
Query: 1602 KNITLIR--TNLEMAMEIKAVSADRQH-GWNPCKESNGGCSHLCL 1643
++R T L M M++ S H G NPC +NG CS LCL
Sbjct: 1818 SGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQLCL 1862
Score = 301 bits (740), Expect = 1e-80
Identities = 211/684 (30%), Positives = 338/684 (49%), Gaps = 60/684 (8%)
Query: 1024 GGCSHLCLLKPGGRSCACPIGIKLNKDGKTCA--DGPIN---YLIFAHRVDIRVISLDVP 1078
G CS LC G C C G L D ++C + P++ L+ A+ +I L
Sbjct: 158 GTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGA 217
Query: 1079 YLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTG------QRKIQRATRLGTHVE--TV-I 1129
+ + P + +D ++ + W G Q K R L V+ T+ I
Sbjct: 218 Q-VSTITPTST-RQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINI 275
Query: 1130 GNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYG 1189
LH + + ID Y+ D + I V +G L+ L +P+ IAL G
Sbjct: 276 SLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMG 335
Query: 1190 YMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSD 1249
+F++D+G K+ER DMDG NR +VD+KI +P+G+ +D + +YW DA + IE D
Sbjct: 336 KVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVD 395
Query: 1250 FDGHDRRTVLSN--VPYPYGIVIVGQHIYWTD-------WKTKALHRADKTNASD-PIVI 1299
++G R+T++ + + YG+ + ++Y T+ KT + R ++ N+++ +V
Sbjct: 396 YEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVI-RVNRFNSTEYQVVT 454
Query: 1300 RKNLEGLMDI-RAIQSERVLENACGTDN----GGCSHLCL--RSPLGYTCACPTGMPFEK 1352
R + G + I + RV +AC D GGCS +CL S TC C +G
Sbjct: 455 RVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGF---- 510
Query: 1353 STTDQTPKKCKSHPEE-FLIF--ATRGSITYISLESPEQWDVTLPVKEVKNTIAVDYHWD 1409
+ K CK E FL++ G I + + + + +P++ + N A+D+H +
Sbjct: 511 -SLGSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAE 569
Query: 1410 LKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDN-EHKVIE 1468
I++ D +I + +E +TI+ + G+ VDW+ +N+YWTD+ K I
Sbjct: 570 TGFIYFADTTSYLIGRQKIDG-TERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTIS 628
Query: 1469 VARLD--GSSRKVLITG-LTEPRALALFPAKGYLYWSDWGEHP------YIERSYLDGSQ 1519
VARL+ +RK LI G +T PRA+ + P G++YW+DW E P +ER+++DGS
Sbjct: 629 VARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSH 688
Query: 1520 RQIIV-QVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHR--VQLVPDAKNPFGM 1576
R I V + +PNGL++D RLYW DA DRI+T LNG R V P+ + FG+
Sbjct: 689 RDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGL 748
Query: 1577 TQFKDYIYWTDWYKKSIIRADKRTG---KNITLIRTNLEMAMEIKAVSADRQH-GWNPCK 1632
+Y++WT++ S+ R ++ G +TL+R+ EI+ A +Q G N C+
Sbjct: 749 CHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCR 808
Query: 1633 ESNGGCSHLCLFRGHEYICACPDD 1656
+NGGCS LCL CAC +D
Sbjct: 809 VNNGGCSSLCLATPGSRQCACAED 832
Score = 284 bits (696), Expect = 2e-75
Identities = 174/543 (32%), Positives = 266/543 (48%), Gaps = 38/543 (6%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
RC F+CK+ C+P ++CD D DC D +DE++C +C EF+CN+ C P W
Sbjct: 3612 RCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAW 3671
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDE-YTCA-DRRCVLKTWLCDGVRDCTNGEDEMN 379
+CD E DC D DE N + + C + + C DR C+ CDG +C +G DE +
Sbjct: 3672 KCDGEDDCGDNSDE-NPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEED 3730
Query: 380 CEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRK---CSAE 436
CE + +E L N + C++ C+ DC G DEE C + K C+
Sbjct: 3731 CEPPTAHTTHCKDKKEFLCRN--QRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATN 3788
Query: 437 EK-C--EKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSF 493
C E C+ T + A CAC GF + C+DI+EC+ + CSQ C+NT G
Sbjct: 3789 ASICGDEARCVRT-EKAAYCACRSGFHTVPGQPGCQDINECL--RFGTCSQLCNNTKGGH 3845
Query: 494 RCGCMTGYILRPDERSCKPTG-ESPTLLFSNRIGIRQVWLTGDN--YMSVVKGLHNA--V 548
C C ++ +CK G E L ++ IR ++ + Y +G +
Sbjct: 3846 LCSCARNFM--KTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGDESVRID 3903
Query: 549 ALDYHYEKKLVFWSENNLRVIR------VAQMNTKN---------MSDVIRWGLETPAGV 593
A+D H + V+W+ + I A T N ++ + GL+ P G+
Sbjct: 3904 AMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGI 3963
Query: 594 AVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPN 653
A+DW+ ++WTDSG +EVA + G R L++ +D+P AI V P ++W+DWG +
Sbjct: 3964 AIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNH 4023
Query: 654 PKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDR--RK 711
PKIE A MDG R+T++ D I WP GL +DY ++YWADAK VI +G D
Sbjct: 4024 PKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAA 4083
Query: 712 VTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEE 771
+ +GL HPF++ +F+D IY + + ++K + + GL+ D+ +
Sbjct: 4084 DSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHK 4143
Query: 772 TPE 774
PE
Sbjct: 4144 QPE 4146
Score = 253 bits (619), Expect = 5e-66
Identities = 136/335 (40%), Positives = 198/335 (59%), Gaps = 17/335 (5%)
Query: 1329 CSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEE--FLIFATRGSITYISLESP 1386
CS C+ + Y C C G + P CK+ +E FLIFA R + ++L+
Sbjct: 2992 CSQRCINTHGSYKCLCVEGY----APRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGS 3047
Query: 1387 EQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDL--NVIRSINMTNMSESKTIISQKLET 1444
+ TL + + N +A+D+ + +MI++TD+ ++IR +++ N S + + L
Sbjct: 3048 ---NYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHL-NGSNVQVLHRTGLSN 3103
Query: 1445 PNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLIT-GLTEPRALALFPAKGYLYWSD 1503
P+GL VDW+ N+YW D IEV++L+G+ R VL++ GL EPRAL + GYLYW+D
Sbjct: 3104 PDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTD 3163
Query: 1504 WGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHR 1563
WG+H I R +DGS R +IV + +PNGLT+DY R+YW DA +D I+ + L+G +R
Sbjct: 3164 WGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNR 3223
Query: 1564 -VQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAVSA 1622
V L D + F +T F+DY+YWTDW KSI RA K TG N TL+ + L M++ A
Sbjct: 3224 HVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHA 3283
Query: 1623 DRQHGW--NPCKESNGGCSHLCLFR-GHEYICACP 1654
RQ +PCK +NGGCS+LCL G + CACP
Sbjct: 3284 LRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACP 3318
Score = 249 bits (609), Expect = 8e-65
Identities = 236/838 (28%), Positives = 361/838 (43%), Gaps = 95/838 (11%)
Query: 301 PGSCNAGEFKCNDG-KCIPERWRCDNERDCADGGDELN--CKPNSIRNCSLDEYTCADRR 357
P +C+ +F C D CI + WRCD ERDC DG DE C + + C +E+ C
Sbjct: 24 PKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTE 83
Query: 358 -CVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKH--VCDG 414
CV + LC+GV+DC +G DE C E Q C +CV C
Sbjct: 84 LCVPMSRLCNGVQDCMDGSDE---GPHCRELQGNCS-----RLGCQHHCVPTLDGPTCYC 135
Query: 415 MKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
D + C +CS C +LC T DG C C G+LL D SC+ +E
Sbjct: 136 NSSFQLQADGKTCKDFDECSVYGTCSQLCTNT-DGSFICGCVEGYLLQPDNRSCKAKNEP 194
Query: 475 MYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGES---PTLLFSNRIG--IRQ 529
+ + N + ++ G I R S T+ + + +G Q
Sbjct: 195 VDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVH-VGDSAAQ 253
Query: 530 VWLTGDNYMSVVKGLHNAVALD-----YHYEKKLVFWSENNLRVI-----RVAQMNTKNM 579
L M +KG + ++ +H E+ + W N + R+ N
Sbjct: 254 TQLKCAR-MPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGD 312
Query: 580 SDVIRWGLE--TPAGVAVDWIHDLLFWTDSGT-RRVEVATLDGSKRAVLVANDLDKPRAI 636
+ V LE P G+A+D +F+TD G +VE +DG R LV + + P I
Sbjct: 313 TCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGI 372
Query: 637 AVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWP-NGLTI--DY---TESKIY 690
+ LV+W D IE D +G R+T+I + GLT+ +Y T S
Sbjct: 373 TLDLVSRLVYWAD-AYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNA 431
Query: 691 WADAKHHVIERAAFDGRDRRKVTT--KG----LPHPFALTLFDDAIYWTDWHTK-----S 739
A K VI F+ + + VT KG + H D + K
Sbjct: 432 NAQQKTSVIRVNRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSD 491
Query: 740 ISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKL-LLYARRKDLRLKQLESKKPIDS 798
I + + +G ++ D +SC++ +L L+Y + + ++ ++ +
Sbjct: 492 ICLLANSHKARTCRCRSGFSLGSD--GKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPD 549
Query: 799 LDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLA 858
M IP+E + + ALD+ ++ I++ D I R ++G+ + TI+ + G+A
Sbjct: 550 EHM-IPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVA 608
Query: 859 FDWITDKIYWTDGGTNR-IEVSKSDGSMRT--LLAWDHIDKPRDIVVNPEGGVMYWSDWG 915
DW+ D +YWTD G + I V++ + + +T L + PR IVV+P G MYW+DW
Sbjct: 609 VDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWE 668
Query: 916 ASP------CIERADMDGGNRKKLIFGQ-MTWPNGLALDLVHNRIYWTDGGNKTIEYANL 968
P +ERA MDG +R + + + WPNGL+LD+ R+YW D IE L
Sbjct: 669 EDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILL 728
Query: 969 DGTGRTKLIE--NLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTG--------------- 1011
+GT R + E L H FGL +G+ +FWT++ + S+ + G
Sbjct: 729 NGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPP 788
Query: 1012 --------AKRRTLG---CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGP 1058
A+++ +G C NNGGCS LCL PG R CAC L+ DG TC P
Sbjct: 789 IFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANP 846
Score = 246 bits (602), Expect = 6e-64
Identities = 130/331 (39%), Positives = 194/331 (58%), Gaps = 13/331 (3%)
Query: 1026 CSHLCLLKPGGRSCACPIGIK-LNKDGKTC--ADGPINYLIFAHRVDIRVISLDVPYLID 1082
CS C+ G C C G D +C +LIFA+R +R ++LD +
Sbjct: 2992 CSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGS---N 3048
Query: 1083 VVLPLPPLKNALGVDVDHSTGLIYWTD-TGQRKIQRATRL-GTHVETVIGNGLHTADGIV 1140
L L NA+ +D D+ +IYWTD T Q + R L G++V+ + GL DG+
Sbjct: 3049 YTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLA 3108
Query: 1141 IDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSA 1200
+D G +YW D GR++IEV++L+G R VLV +GL PRA+ + + GY++W+DWG +
Sbjct: 3109 VDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHS 3168
Query: 1201 KIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLS 1260
I R MDG++R VIVD KI WPNGL +D + R+YW DA+ IE + DG +R VLS
Sbjct: 3169 LIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLS 3228
Query: 1261 -NVPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDI---RAIQSER 1316
++P+ + + + ++YWTDW+TK+++RA KT ++ ++ L MD+ A++
Sbjct: 3229 QDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPD 3288
Query: 1317 VLENACGTDNGGCSHLCLRSP-LGYTCACPT 1346
V + C +NGGCS+LCL SP G+ CACPT
Sbjct: 3289 VPNHPCKVNNGGCSNLCLLSPGGGHKCACPT 3319
Score = 235 bits (576), Expect = 8e-61
Identities = 128/320 (40%), Positives = 176/320 (55%), Gaps = 34/320 (10%)
Query: 763 DIHSRSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNS 822
D HS E L++A R LR K +D + + + + +AVALD+D +
Sbjct: 3017 DPHSCKAVTDEEPFLIFANRYYLR------KLNLDGSNYTLLKQGLNNAVALDFDYREQM 3070
Query: 823 IFWTDV--EKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSK 880
I+WTDV + I R +LNGS+ + + L P GLA DW+ +YW D G + IEVSK
Sbjct: 3071 IYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSK 3130
Query: 881 SDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTW 940
+G+ RT+L + +PR +VV+ + G +YW+DWG I R MDG +R ++ ++TW
Sbjct: 3131 LNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITW 3190
Query: 941 PNGLALDLVHNRIYWTDGGNKTIEYANLDGTGR-TKLIENLPHPFGLDLYGDEVFWTDWD 999
PNGL LD V RIYW D IE+A+LDG+ R L +++PH F L L+ D V+WTDW+
Sbjct: 3191 PNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWE 3250
Query: 1000 TQSIQAANKDTGAKRRTL------------------------GCGKNNGGCSHLCLLKP- 1034
T+SI A+K TG + L C NNGGCS+LCLL P
Sbjct: 3251 TKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPG 3310
Query: 1035 GGRSCACPIGIKLNKDGKTC 1054
GG CACP L DG+TC
Sbjct: 3311 GGHKCACPTNFYLGSDGRTC 3330
Score = 206 bits (504), Expect = 4e-52
Identities = 152/492 (30%), Positives = 222/492 (45%), Gaps = 38/492 (7%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKC-NDGKCIPERW 321
C+E FEC+N +C+ K + CDG +DCGD +DE + +C F C C+PERW
Sbjct: 2734 CSEAQFECQNHRCISKQWLCDGSDDCGDGSDE-AAHCEGKTCGPSSFSCPGTHVCVPERW 2792
Query: 322 RCDNERDCADGGDE---LNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEM 378
CD ++DCADG DE C NS C E+ C +R+C+ K ++CD RDC +G DE
Sbjct: 2793 LCDGDKDCADGADESIAAGCLYNS--TCDDREFMCQNRQCIPKHFVCDHDRDCADGSDE- 2849
Query: 379 NCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKC-SAEE 437
S E + TC P E +N R +R+ CDG DC D + P C S E
Sbjct: 2850 ----SPECEYPTCGPSEFRCANG-RCLSSRQWECDGENDC--HDQSDEAPKNPHCTSPEH 2902
Query: 438 KC----EKLCITTYDGHAACACPMGFLLAE--DKYSCRDIDECMYEQDPVCSQTCSNTVG 491
KC + LC + A C + D+ C I+EC+ + CSQ C +
Sbjct: 2903 KCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCH-INECLSRKLSGCSQDCEDLKI 2961
Query: 492 SFRCGCMTGYILRPDERSCKPTGE-SPTLLFSNR-IGIRQVW--LTGDNYMSVVKGLHNA 547
F+C C G+ L+ D R+C E S T S R I + L + Y H+
Sbjct: 2962 GFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTHGSYKCLCVEGYAPRGGDPHSC 3021
Query: 548 VALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDS 607
A+ E L+F + LR + + N +++ GL + D+ +++WTD
Sbjct: 3022 KAVT-DEEPFLIFANRYYLRKLNLDGSN----YTLLKQGLNNAVALDFDYREQMIYWTDV 3076
Query: 608 GTR--RVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDK 665
T+ + L+GS VL L P +AV ++W D G IE + ++G
Sbjct: 3077 TTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKG-RDTIEVSKLNGAY 3135
Query: 666 RKTVIYDEIFWPNGLTIDYTESKIYWAD-AKHHVIERAAFDGRDRRKVTTKGLPHPFALT 724
R ++ + P L +D +YW D H +I R DG R + + P LT
Sbjct: 3136 RTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLT 3195
Query: 725 L--FDDAIYWTD 734
L + IYW D
Sbjct: 3196 LDYVTERIYWAD 3207
Score = 198 bits (484), Expect = 1e-49
Identities = 106/288 (36%), Positives = 160/288 (55%), Gaps = 9/288 (3%)
Query: 482 CSQTCSNTVGSFR-CGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSV 540
CSQ C T + R C C GY LR +++C+ G LL+S GIR + L ++
Sbjct: 1857 CSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGSF--LLYSVHEGIRGIPLDPNDKSDA 1914
Query: 541 ---VKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDW 597
V G AV +D+H E ++W + L I A+ + DV+ G+ G+AVDW
Sbjct: 1915 LVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDW 1974
Query: 598 IHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIE 657
I ++WTD G +EVA L+GS R V+++ LDKPRAI VHP +FWT+WG P+IE
Sbjct: 1975 IAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIE 2034
Query: 658 RADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFD-GRDRRKVTTKG 716
R+ +DG +R ++ I WPNG+++DY + K+YW DA+ IER + G +R V +
Sbjct: 2035 RSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSN 2094
Query: 717 LPHPFALTLFDDAIYWTD-WHTK-SISTVNKNTGMGIQTVHAGLNVPM 762
F++++F+D IYW+D H SI +K+ + G+ V +
Sbjct: 2095 NMDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQL 2142
Score = 191 bits (465), Expect = 2e-47
Identities = 174/615 (28%), Positives = 253/615 (41%), Gaps = 78/615 (12%)
Query: 158 CDEH---ENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIG 214
C +H +R C + N CI WLCDGDNDCG+ DE N ++ P S G
Sbjct: 890 CHQHTCPSDRFKCEN-NRCIPNRWLCDGDNDCGNSEDESNATC--SARTCPPNQFSCASG 946
Query: 215 DVITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEI-DFECKNT 273
I I+ T C LD+ RS + C + F C N
Sbjct: 947 RCIP-----ISWT-----------C---DLDDDCGDRSDESASCAYPTCFPLTQFTCNNG 987
Query: 274 KCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGG 333
+C+ +++CD DNDCGD +DE C SC++ +FKCN G+CIPE W CD + DC D
Sbjct: 988 RCININWRCDNDNDCGDNSDEAGC---SHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYS 1044
Query: 334 DE--LNCKPNSIR---NCSLDEYTC-ADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEED 387
DE NC + R C DE+ C D C+ W CDG DC + DE SCE
Sbjct: 1045 DETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEK----SCEGV 1100
Query: 388 QYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC------PLKRKCSAEEK-C- 439
+ C P C+++ VCDG DC DEE C P C+ C
Sbjct: 1101 THVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCL 1160
Query: 440 --EKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVG-SFRCG 496
+KLC DG+ C +++ C D+C CS CS G C
Sbjct: 1161 PPDKLC----DGNDDCGDG-----SDEGELC---DQCSLNNGG-CSHNCSVAPGEGIVCS 1207
Query: 497 CMTGYILRPDERSCKPTGE-SPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYE 555
C G L PD +C+ + L S + + + Y V
Sbjct: 1208 CPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPF 1267
Query: 556 KKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVA 615
K + +S N IR ++ + S V+ GL + L+WTD ++
Sbjct: 1268 KPFIIFS--NRHEIRRIDLHKGDYS-VLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRG 1324
Query: 616 TL--DGSKRA--VLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIY 671
L +G+ + V++ L P +AV ++W + + +IE A +DG R T++
Sbjct: 1325 KLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLD-QIEVAKLDGTLRTTLLA 1383
Query: 672 DEIFWPNGLTIDYTESKIYWA--DAKHHVIERAAFDGRDRRKVTTK----GLPHPFALTL 725
+I P + +D + ++W DA IE A+ G RR V + G P+ +
Sbjct: 1384 GDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDY 1443
Query: 726 FDDAIYWTDWHTKSI 740
+ I W D + +I
Sbjct: 1444 LEKRILWIDARSDAI 1458
Score = 180 bits (438), Expect = 4e-44
Identities = 156/549 (28%), Positives = 252/549 (45%), Gaps = 63/549 (11%)
Query: 559 VFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTR-RVEVATL 617
++W++ VI VA++N VI GL+ P + V LFWT+ G R+E + L
Sbjct: 1979 IYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRL 2038
Query: 618 DGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMD-GDKRKTVIYDEIFW 676
DG++R VLV + P I+V D ++W D KIER D++ G+ R+ V+
Sbjct: 2039 DGTERVVLVNVSISWPNGISVDYQDGKLYWCD-ARTDKIERIDLETGENREVVLSSNNM- 2096
Query: 677 PNGLTIDYTESKIYWADAKHH--VIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYWTD 734
+ ++ E IYW+D H I+R + D G+ + L D ++ D
Sbjct: 2097 -DMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGI----GVQLKDIKVFNRD 2151
Query: 735 WHTKSISTVNKNTGMGIQTVHAG--------LNVPMDIHSRSCEETPEKLLLYARRKDLR 786
+ N G ++ G + + SC E LLY+ R L+
Sbjct: 2152 RQKGTNVCAVANGGCQQLCLYRGRGQRACACAHGMLAEDGASCREYAG-YLLYSERTILK 2210
Query: 787 LKQLESKKPIDS-LDMVIPVETIKSAVALDWDQKS-------NSIFWTDVEKDTINRAYL 838
L ++ +++ + E +K+ +AL +D ++ N IF++D+ I +
Sbjct: 2211 SIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQIND 2270
Query: 839 NGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSM------RTLLAWD 892
+GS + TIV+ N+ GLA+ D +YWT T+ I D + T++
Sbjct: 2271 DGSRRITIVE-NVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMS 2329
Query: 893 HIDKPRDIVVNPEGGVMYWSDWGAS-PCIERADMDGGNRKKLIFGQMTWPNGLALDLVHN 951
D PR V++ +M+W++W P I RA + G N LI + PNGLA+D
Sbjct: 2330 GDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAE 2389
Query: 952 RIYWTDGGNKTIEYANLDGTGRTKLIENLP-HPFGLDLYGDEVFWTDWDTQSIQAANKDT 1010
++Y++D IE DG+ R ++++ P HPFGL +YG+ +FWTDW +++Q ANK
Sbjct: 2390 KLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHV 2449
Query: 1011 GAKRRTLG------------------------CGKNNGGCSHLCLLKPGGR-SCACPIGI 1045
G+ + L C NNGGC LCLL G +C+C G
Sbjct: 2450 GSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCR-GG 2508
Query: 1046 KLNKDGKTC 1054
++ +D TC
Sbjct: 2509 RILQDDLTC 2517
Score = 173 bits (422), Expect = 4e-42
Identities = 99/297 (33%), Positives = 142/297 (47%), Gaps = 34/297 (11%)
Query: 169 STNVCIALEWLCDGDNDCGDFSDEINCDV----------VKTSLLVPS---ANASLNIGD 215
ST +C ++CDGDNDC D SDE NCD+ T+ +P N N GD
Sbjct: 3382 STGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGD 3441
Query: 216 VITN---PTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVEL--MRCAEIDFEC 270
P V A + I D + ++P M C +F C
Sbjct: 3442 GEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRC 3501
Query: 271 KNT-KCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDC 329
K++ +C+P ++CDG++DCGD +DE +C +F+C + +C+P RW+CD + DC
Sbjct: 3502 KDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDC 3561
Query: 330 ADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQY 389
D DE +C P R CS E++CA+ RC+ W CDG DC +G DE +C C+ DQ+
Sbjct: 3562 GDNSDEESCTP---RPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQF 3618
Query: 390 TCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPL-KRKCSAEE-KCEK-LC 443
C+ +C+ + CD DC G DEE C R C +E +C LC
Sbjct: 3619 QCKS---------GHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLC 3666
Score = 164 bits (399), Expect = 2e-39
Identities = 108/352 (30%), Positives = 166/352 (47%), Gaps = 33/352 (9%)
Query: 1327 GGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEF--LIFATRGSITYISLE 1384
G CS LC + G+ C+C F K T CK+ E+ L A I +
Sbjct: 3832 GTCSQLCNNTKGGHLCSCARN--FMK-----THNTCKAEGSEYQVLYIADDNEIRSLFPG 3884
Query: 1385 SPEQ-WDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVI--RSINM----TNMSESKTI 1437
P ++ E A+D H +++T+ I RS+ T + +
Sbjct: 3885 HPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQ 3944
Query: 1438 ISQK--------LETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITGLT-EPR 1488
I + L+ P G+ +DW+A N+YWTD+ VIEVA++ G +RK LI+G+ EP
Sbjct: 3945 IDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPH 4004
Query: 1489 ALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDA 1548
A+ + P +G +YWSDWG HP IE + +DG+ R+ +VQ ++ +P GL +DY RLYW DA
Sbjct: 4005 AIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADA 4064
Query: 1549 LKDRIDTSDLNGQHRVQLVPDAK----NPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNI 1604
I + LNG + + D+K +PF + F+DYIY + + + K +
Sbjct: 4065 KLSVIGSIRLNGTDPI-VAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPL 4123
Query: 1605 TLIRTNLEMAMEIKAVSADRQ-HGWNPCKESNGGCSHLCLFRGHEYICACPD 1655
+ L A ++ +Q NPC C LCL +C CP+
Sbjct: 4124 VNLTGGLSHASDVVLYHQHKQPEVTNPCDRKK--CEWLCLLSPSGPVCTCPN 4173
Score = 159 bits (385), Expect = 1e-37
Identities = 112/360 (31%), Positives = 153/360 (42%), Gaps = 29/360 (8%)
Query: 1024 GGCSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGP-INYLIFAHRVDIRVISLDVPY-L 1080
G CS LC GG C+C K TC A+G L A +IR + P+
Sbjct: 3832 GTCSQLCNNTKGGHLCSCARNFM--KTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSA 3889
Query: 1081 IDVVLPLPPLKNALGVDVDHSTGLIYWTD------------------TGQRKIQRATRLG 1122
+ +DV G +YWT+ T R ++ R
Sbjct: 3890 YEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGV 3949
Query: 1123 THVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAI 1182
TH+ +GL GI ID +YWTD GR+ IEVA++ G NRK L+ +D P AI
Sbjct: 3950 THLNI---SGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAI 4006
Query: 1183 ALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKI 1242
+ G M+WSDWG KIE A MDG R +V + I+WP GLA+D RLYW DAK+
Sbjct: 4007 VVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKL 4066
Query: 1243 LTIESSDFDGHDRRTVLSN---VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVI 1299
I S +G D + + +P+ I + +IY + + + K S + +
Sbjct: 4067 SVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNL 4126
Query: 1300 RKNLEGLMDIRAIQSERVLENACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTP 1359
L D+ + E D C LCL SP G C CP G + T P
Sbjct: 4127 TGGLSHASDVVLYHQHKQPEVTNPCDRKKCEWLCLLSPSGPVCTCPNGKRLDNGTCVPVP 4186
Score = 137 bits (332), Expect = 3e-31
Identities = 100/336 (29%), Positives = 145/336 (43%), Gaps = 42/336 (12%)
Query: 762 MDIHSRSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSN 821
M H+ E E +LY D ++ L P + + + A+D K+
Sbjct: 3854 MKTHNTCKAEGSEYQVLYIA-DDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHVKAG 3912
Query: 822 SIFWTDVEKDTINRAYL--------NGSHQ-------TTIVDSNLIWPAGLAFDWITDKI 866
++WT+ TI+ L + H+ T + S L P G+A DW+ +
Sbjct: 3913 RVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNV 3972
Query: 867 YWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMD 926
YWTD G + IEV++ G R L ID+P IVV+P G MYWSDWG P IE A MD
Sbjct: 3973 YWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMD 4032
Query: 927 GGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN---LPHP 983
G R+ L+ + WP GLA+D + R+YW D I L+GT ++ L HP
Sbjct: 4033 GTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHP 4092
Query: 984 FGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTLGCGKNNGG------------------ 1025
F +D++ D ++ + + +K + L G ++
Sbjct: 4093 FSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVTNPCD 4152
Query: 1026 ---CSHLCLLKPGGRSCACPIGIKLNKDGKTCADGP 1058
C LCLL P G C CP G +L D TC P
Sbjct: 4153 RKKCEWLCLLSPSGPVCTCPNGKRL--DNGTCVPVP 4186
Score = 136 bits (330), Expect = 5e-31
Identities = 90/261 (34%), Positives = 122/261 (46%), Gaps = 33/261 (12%)
Query: 169 STNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTK 228
S C++ C+G +DCGD SDEI C+ KT+ V G I N +
Sbjct: 2574 SNGRCVSNMLWCNGADDCGDGSDEIPCN--KTACGVGEFRC--RDGTCIGNSS------- 2622
Query: 229 PTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFE-CKNTK-CVPKDFQCDGDN 286
R F + + N +T + + F+ C+ T C + CDG N
Sbjct: 2623 -----RCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGAN 2677
Query: 287 DCGDWTDEDSCPMVPGS-CNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRN 345
DCGD++DE CP V C F C G+CIP W CD E DC G DE +C +
Sbjct: 2678 DCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCN----KF 2733
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDE-MNCE-VSCEEDQYTCRPQEHLMSNAFR 403
CS ++ C + RC+ K WLCDG DC +G DE +CE +C ++C P H+
Sbjct: 2734 CSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSC-PGTHV------ 2786
Query: 404 NCVNRKHVCDGMKDCPRGDDE 424
CV + +CDG KDC G DE
Sbjct: 2787 -CVPERWLCDGDKDCADGADE 2806
Score = 132 bits (318), Expect = 1e-29
Identities = 87/278 (31%), Positives = 135/278 (48%), Gaps = 16/278 (5%)
Query: 482 CSQTCS-NTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSV 540
CS C N + C C L D +C + LL++ ++ IR V L Y +
Sbjct: 1549 CSHLCLINYNRTVSCACPHLMKLHKDNTTCYEFKKF--LLYARQMEIRGVDLDAPYYNYI 1606
Query: 541 VK----GLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVD 596
+ + N LDY ++ V+WS+ + I+ A +N + V+ L G+AVD
Sbjct: 1607 ISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVD 1666
Query: 597 WIHDLLFWT--DSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNP 654
W+ LFWT D+ +++ VA LDGS + +V L++P + VHP ++WTD G N
Sbjct: 1667 WVSRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPHGLVVHPLRGKLYWTD-GDN- 1723
Query: 655 KIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTT 714
I A+MDG R T+++ P GL ID+ ESK+YW + +H I R DG +
Sbjct: 1724 -ISMANMDGSNR-TLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDA 1781
Query: 715 --KGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMG 750
L AL + D ++W D ++ + T +K G G
Sbjct: 1782 MRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSG 1819
Score = 128 bits (310), Expect = 1e-28
Identities = 71/197 (36%), Positives = 96/197 (48%), Gaps = 14/197 (7%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
+C +F C N++C+ + ++CDGDNDC D +DE +C + FKC + +CIP RW
Sbjct: 853 QCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRW 912
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCE 381
CD + DC + DE N S R C ++++CA RC+ +W CD DC + DE
Sbjct: 913 LCDGDNDCGNSEDESNA-TCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDE---S 968
Query: 382 VSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE-KCE 440
SC TC P N R C+N CD DC DE C CS+ + KC
Sbjct: 969 ASCAYP--TCFPLTQFTCNNGR-CININWRCDNDNDCGDNSDEAGC--SHSCSSTQFKCN 1023
Query: 441 K-LCIT---TYDGHAAC 453
CI T DG C
Sbjct: 1024 SGRCIPEHWTCDGDNDC 1040
Score = 125 bits (301), Expect = 2e-27
Identities = 64/182 (35%), Positives = 94/182 (51%), Gaps = 17/182 (9%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDE-DSCPMVPGSCNAGEFKCNDGKCIPERW 321
C F CKN KC+P ++CD ++DCGD +DE CP C G+F+C+ G C +
Sbjct: 3334 CTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEF--KCRPGQFQCSTGICTNPAF 3391
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNC 380
CD + DC D DE NC I C ++ C + RC+ + C+G +C +GEDE +C
Sbjct: 3392 ICDGDNDCQDNSDEANC---DIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDC 3448
Query: 381 -EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE-K 438
EV+C +Q+ C + + C+ R VCD DC G DE + C +E +
Sbjct: 3449 PEVTCAPNQFQC--------SITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFR 3500
Query: 439 CE 440
C+
Sbjct: 3501 CK 3502
Score = 124 bits (298), Expect = 4e-27
Identities = 88/281 (31%), Positives = 120/281 (42%), Gaps = 43/281 (15%)
Query: 173 CIALEWLCDGDNDCGDFSDE-INCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTV 231
CI W CD ++DCGD SDE +C K + G + TNP +
Sbjct: 3346 CIPFWWKCDTEDDCGDHSDEPPDCPEFKCR----PGQFQCSTG-ICTNPAFICDGDNDCQ 3400
Query: 232 VIRYESFC-AKKALDNAANPRSTWNQPVELMRC--------AEIDFECKNTKCVPKDFQ- 281
E+ C L + +T + RC E + +C C P FQ
Sbjct: 3401 DNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQC 3460
Query: 282 ------------CDGDNDCGDWTDED-SCPMVPGSCNAGEFKCND-GKCIPERWRCDNER 327
CD DNDC D +DE +C + +C EF+C D G+CIP RW+CD E
Sbjct: 3461 SITKRCIPRVWVCDRDNDCVDGSDEPANCTQM--TCGVDEFRCKDSGRCIPARWKCDGED 3518
Query: 328 DCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV-SCEE 386
DC DG DE + + R C ++ C + RCV W CD DC + DE +C C E
Sbjct: 3519 DCGDGSDEPKEECDE-RTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSE 3577
Query: 387 DQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC 427
+++C A C+ + CDG DC G DE+ C
Sbjct: 3578 SEFSC---------ANGRCIAGRWKCDGDHDCADGSDEKDC 3609
Score = 123 bits (297), Expect = 5e-27
Identities = 82/271 (30%), Positives = 122/271 (45%), Gaps = 26/271 (9%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALT-KPTV 231
CI C+ DC D SDE+NC S + L + V+ P +L P+
Sbjct: 2617 CIGNSSRCNQFVDCEDASDEMNCSATDCS-----SYFRLGVKGVLFQPCERTSLCYAPSW 2671
Query: 232 VIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDW 291
V + C + D P V+ RC F C + +C+P + CD ++DC
Sbjct: 2672 VCDGANDCGDYS-DERDCPG------VKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHG 2724
Query: 292 TDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDE-LNCKPNSIRNCSLDE 350
DE C C+ +F+C + +CI ++W CD DC DG DE +C+ + C
Sbjct: 2725 EDETHCNKF---CSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEG---KTCGPSS 2778
Query: 351 YTCADRR-CVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRK 409
++C CV + WLCDG +DC +G DE + C + TC +E + N R C+ +
Sbjct: 2779 FSCPGTHVCVPERWLCDGDKDCADGADE-SIAAGCLYNS-TCDDREFMCQN--RQCIPKH 2834
Query: 410 HVCDGMKDCPRGDDEE-RCPLKRKCSAEEKC 439
VCD +DC G DE C +E +C
Sbjct: 2835 FVCDHDRDCADGSDESPECEYPTCGPSEFRC 2865
Score = 118 bits (283), Expect = 3e-25
Identities = 64/183 (34%), Positives = 95/183 (51%), Gaps = 22/183 (12%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKC-NDGKCIPER 320
+C F+C C F CDGDNDC D +DE +C + C +FKC N +CIP
Sbjct: 3373 KCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDI--HVCLPSQFKCTNTNRCIPGI 3430
Query: 321 WRCDNERDCADGGDELNCKPNSIRNCSLDEYTCA-DRRCVLKTWLCDGVRDCTNGEDE-M 378
+RC+ + +C DG DE +C P C+ +++ C+ +RC+ + W+CD DC +G DE
Sbjct: 3431 FRCNGQDNCGDGEDERDC-PEV--TCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPA 3487
Query: 379 NC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE 437
NC +++C D++ C+ C+ + CDG DC G DE K +C E
Sbjct: 3488 NCTQMTCGVDEFRCKDS--------GRCIPARWKCDGEDDCGDGSDEP----KEECD-ER 3534
Query: 438 KCE 440
CE
Sbjct: 3535 TCE 3537
Score = 111 bits (268), Expect = 2e-23
Identities = 86/319 (26%), Positives = 144/319 (45%), Gaps = 30/319 (9%)
Query: 482 CSQTCS-NTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSV 540
C Q C G C C G +L D SC+ + LL+S R ++ + L+ + ++
Sbjct: 2166 CQQLCLYRGRGQRACACAHG-MLAEDGASCREY--AGYLLYSERTILKSIHLSDERNLNA 2222
Query: 541 V-------KGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSD------VIRWGL 587
+ + N +AL + Y + N + + N + ++D I +
Sbjct: 2223 PVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIVENV 2282
Query: 588 ETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSK------RAVLVANDLDKPRAIAVHPG 641
+ G+A D L+WT T + T+D ++ V+ + D PRA +
Sbjct: 2283 GSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDEC 2342
Query: 642 DALVFWTDWGP-NPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIE 700
L+FWT+W +P I RA + G T+I +I PNGL ID+ K+Y++DA IE
Sbjct: 2343 QNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIE 2402
Query: 701 RAAFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGL-N 759
R +DG R + HPF L ++ + I+WTDW +++ NK+ G ++ + +
Sbjct: 2403 RCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQ 2462
Query: 760 VPMDI-----HSRSCEETP 773
PM I + SCE +P
Sbjct: 2463 QPMGIIAVANDTNSCELSP 2481
Score = 104 bits (250), Expect = 3e-21
Identities = 68/236 (28%), Positives = 99/236 (41%), Gaps = 24/236 (10%)
Query: 264 AEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRC 323
A+ +FEC N +C+ CDG C D +DE C +C++G+C+ C
Sbjct: 2526 AQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWC 2585
Query: 324 DNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVS 383
+ DC DG DE+ C + C + E+ C D C+ + C+ DC + DEMNC +
Sbjct: 2586 NGADDCGDGSDEIPCNKTA---CGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSAT 2642
Query: 384 CEEDQYTCRPQEHLMSNAFRN--CVNRKHVCDGMKDCPRGDDEERCP-LKRKCSAEEKCE 440
+ + L R C VCDG DC DE CP +KR
Sbjct: 2643 DCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKR--------- 2693
Query: 441 KLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV-CSQTCSNTVGSFRC 495
C Y ACP G + ++C D+C + +D C++ CS F C
Sbjct: 2694 PRCPLNY-----FACPSGRCIPM-SWTCDKEDDCEHGEDETHCNKFCSE--AQFEC 2741
Score = 104 bits (249), Expect = 3e-21
Identities = 65/196 (33%), Positives = 91/196 (46%), Gaps = 24/196 (12%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
RC + +C N +CV C+G +DCGD +DE C +C GEF+C DG CI
Sbjct: 2565 RCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKT--ACGVGEFRCRDGTCIGNSS 2622
Query: 322 RCDNERDCADGGDELNCKPNSIRNCS----------LDEYTCADRRCVLKTWLCDGVRDC 371
RC+ DC D DE+NC S +CS L + C +W+CDG DC
Sbjct: 2623 RCNQFVDCEDASDEMNC---SATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDC 2679
Query: 372 TNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKR 431
+ DE +C + C P + + R C+ CD DC G+DE C +
Sbjct: 2680 GDYSDERDCP---GVKRPRC-PLNYFACPSGR-CIPMSWTCDKEDDCEHGEDETHC--NK 2732
Query: 432 KCS-AEEKCEK-LCIT 445
CS A+ +C+ CI+
Sbjct: 2733 FCSEAQFECQNHRCIS 2748
Score = 101 bits (242), Expect = 2e-20
Identities = 49/128 (38%), Positives = 60/128 (46%), Gaps = 8/128 (6%)
Query: 301 PGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVL 360
P C GEF C + +CI ERW+CD + DC D DE + C D + C + RC+
Sbjct: 851 PPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQ-HTCPSDRFKCENNRCIP 909
Query: 361 KTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDC-P 419
WLCDG DC N EDE N S TC P + S A C+ CD DC
Sbjct: 910 NRWLCDGDNDCGNSEDESNATCSAR----TCPPNQ--FSCASGRCIPISWTCDLDDDCGD 963
Query: 420 RGDDEERC 427
R D+ C
Sbjct: 964 RSDESASC 971
Score = 93.5 bits (222), Expect = 6e-18
Identities = 77/288 (26%), Positives = 126/288 (43%), Gaps = 16/288 (5%)
Query: 1025 GCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPY---LI 1081
GCS C G C C G +L DG+TCAD ++ R I+ Y +
Sbjct: 2951 GCSQDCEDLKIGFKCRCRPGFRLKDDGRTCAD--VDECSTTFPCSQRCINTHGSYKCLCV 3008
Query: 1082 DVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVI 1141
+ P ++ D LI+ R R L T++ GL+ A +
Sbjct: 3009 EGYAPRGGDPHSCKAVTDEEPFLIF----ANRYYLRKLNLDGSNYTLLKQGLNNAVALDF 3064
Query: 1142 DSTGRKIYWTD--GGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTS 1199
D + IYWTD + I L+G N +VL TGL +P +A+ + G ++W D G
Sbjct: 3065 DYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRD 3124
Query: 1200 AKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFDGHDRRTV 1258
IE + ++G R V+V + ++ P L +D G LYW D I DG R +
Sbjct: 3125 T-IEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVI 3183
Query: 1259 L-SNVPYPYGIVI--VGQHIYWTDWKTKALHRADKTNASDPIVIRKNL 1303
+ + + +P G+ + V + IYW D + + A ++ +V+ +++
Sbjct: 3184 VDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDI 3231
Score = 92.7 bits (220), Expect = 1e-17
Identities = 54/188 (28%), Positives = 83/188 (44%), Gaps = 27/188 (14%)
Query: 303 SCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKT 362
+C A +F C + KCIP W+CD E DC D DE P C ++ C+ C
Sbjct: 3333 NCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEF--KCRPGQFQCSTGICTNPA 3390
Query: 363 WLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGD 422
++CDG DC + DE NC++ + C P + +N R C+ C+G +C G+
Sbjct: 3391 FICDGDNDCQDNSDEANCDI------HVCLPSQFKCTNTNR-CIPGIFRCNGQDNCGDGE 3443
Query: 423 DEERC------PLKRKCSAEEKC---------EKLCITTYDGHAACACPMGFLLAEDKYS 467
DE C P + +CS ++C + C+ D A C D++
Sbjct: 3444 DERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCT---QMTCGVDEFR 3500
Query: 468 CRDIDECM 475
C+D C+
Sbjct: 3501 CKDSGRCI 3508
Score = 91.1 bits (216), Expect = 3e-17
Identities = 79/296 (26%), Positives = 140/296 (47%), Gaps = 21/296 (7%)
Query: 1019 CGKNNGGCSHLCLLKPG-GRSCACPIGIKLNKDGKTC--ADGPINYLIFAHRVDIRVISL 1075
C NNGGCSH C + PG G C+CP+G++L D TC +L + + D S+
Sbjct: 1185 CSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSV 1244
Query: 1076 DVPYLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHT 1135
VL P ++ +D +I+ + + +I+R L +V+ GL
Sbjct: 1245 KCSCYEGWVLE-PDGESCRSLD-PFKPFIIF---SNRHEIRRID-LHKGDYSVLVPGLRN 1298
Query: 1136 ADGIVIDSTGRKIYWTDGGRNSIEVAEL--DG--RNRKVLVWTGLDSPRAIALHYEYGYM 1191
+ + +YWTD + I +L +G + +V++ GL +P +A+ + G +
Sbjct: 1299 TIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNI 1358
Query: 1192 FWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWN--DAKILTIESSD 1249
+W + +IE A +DG R ++ I+ P +A+D +G L+W DA + IE++
Sbjct: 1359 YWVE-SNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAAS 1417
Query: 1250 FDGHDRRTV---LSNVPYPYGIVI--VGQHIYWTDWKTKALHRADKTNASDPIVIR 1300
G RRTV + +P G+ + + + I W D ++ A++ A + V+R
Sbjct: 1418 MSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLR 1473
Score = 87.8 bits (208), Expect = 3e-16
Identities = 71/261 (27%), Positives = 112/261 (42%), Gaps = 24/261 (9%)
Query: 91 KAIDVIHTDPDDGPLNEGTEDDAGCITP-CLKIN-FSCQISCTCIPMEKRXXXXXXXXXX 148
+ I + T D + +++ A C P C + F+C + CI + R
Sbjct: 947 RCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCN-NGRCININWRCDNDNDCGDN 1005
Query: 149 XXXXXXXRSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSAN 208
SC + + C+S CI W CDGDNDCGD+SDE + + + P
Sbjct: 1006 SDEAGCSHSCSSTQFK--CNSGR-CIPEHWTCDGDNDCGDYSDETHANCTNQATRPP--- 1059
Query: 209 ASLNIGDVITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDF 268
G T+ L + +R+ +D +++ +S + V + + F
Sbjct: 1060 -----GGCHTD-EFQCRLDGLCIPLRWRCDGDTDCMD-SSDEKSC--EGVTHVCDPSVKF 1110
Query: 269 ECKNT-KCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKC--NDGKCIPERWRCDN 325
CK++ +C+ K + CDGDNDC D +DE++C + +C C N C+P CD
Sbjct: 1111 GCKDSARCISKAWVCDGDNDCEDNSDEENCESL--ACRPPSHPCANNTSVCLPPDKLCDG 1168
Query: 326 ERDCADGGDELN-CKPNSIRN 345
DC DG DE C S+ N
Sbjct: 1169 NDDCGDGSDEGELCDQCSLNN 1189
Score = 83.4 bits (197), Expect = 7e-15
Identities = 70/266 (26%), Positives = 122/266 (45%), Gaps = 18/266 (6%)
Query: 685 TESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLF--DDAIYWTDWHTKS--I 740
T+ + + A + + + DG + + +GL + AL + IYWTD T+ I
Sbjct: 3025 TDEEPFLIFANRYYLRKLNLDGSNYT-LLKQGLNNAVALDFDYREQMIYWTDVTTQGSMI 3083
Query: 741 STVNKNTGMGIQTVH-AGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESKKPIDSL 799
++ N G +Q +H GL+ P + + + L + +D +E K +
Sbjct: 3084 RRMHLN-GSNVQVLHRTGLSNPDGL---AVDWVGGNLYWCDKGRDT----IEVSKLNGAY 3135
Query: 800 DMVIPVETIKSAVALDWDQKSNSIFWTDV-EKDTINRAYLNGSHQTTIVDSNLIWPAGLA 858
V+ ++ AL D ++ ++WTD + I R ++GS ++ IVD+ + WP GL
Sbjct: 3136 RTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLT 3195
Query: 859 FDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASP 918
D++T++IYW D + IE + DGS R ++ I P + +YW+DW +
Sbjct: 3196 LDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDI--PHIFALTLFEDYVYWTDW-ETK 3252
Query: 919 CIERADMDGGNRKKLIFGQMTWPNGL 944
I RA G K L+ + P L
Sbjct: 3253 SINRAHKTTGTNKTLLISTLHRPMDL 3278
Score = 78.6 bits (185), Expect = 2e-13
Identities = 72/271 (26%), Positives = 104/271 (38%), Gaps = 28/271 (10%)
Query: 107 EGTEDDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTI 166
E ED+ C C + F CQ + CI + +
Sbjct: 2722 EHGEDETHCNKFCSEAQFECQ-NHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFS 2780
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIAL 226
C T+VC+ WLCDGD DC D +DE + L N++ + + + I
Sbjct: 2781 CPGTHVCVPERWLCDGDKDCADGADE---SIAAGCLY----NSTCDDREFMCQNRQCI-- 2831
Query: 227 TKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCV-PKDFQCDGD 285
V ++ CA + D + P E RCA N +C+ + ++CDG+
Sbjct: 2832 -PKHFVCDHDRDCADGS-DESPECEYPTCGPSE-FRCA-------NGRCLSSRQWECDGE 2881
Query: 286 NDCGDWTDE----DSCPMVPGSCNA-GEFKCNDGKCIPERWRCDNERDCADGGDELNCKP 340
NDC D +DE C CNA +F C+ G+C+ E C+ + DC D DE C
Sbjct: 2882 NDCHDQSDEAPKNPHCTSPEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHI 2941
Query: 341 NSI--RNCSLDEYTCADRRCVLKTWLCDGVR 369
N R S C D + K G R
Sbjct: 2942 NECLSRKLSGCSQDCEDLKIGFKCRCRPGFR 2972
Score = 74.9 bits (176), Expect = 2e-12
Identities = 75/267 (28%), Positives = 108/267 (40%), Gaps = 34/267 (12%)
Query: 102 DGPLNEGTEDDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEH 161
D + +++++ PC + FSC + CI + CD
Sbjct: 3558 DNDCGDNSDEESCTPRPCSESEFSCA-NGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMD 3616
Query: 162 ENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDV-VKTSLLVPSANASLNIGDVITNP 220
+ + C S + CI L W CD D DC D SDE C V+T L + N
Sbjct: 3617 QFQ--CKSGH-CIPLRWRCDADADCMDGSDEEACGTGVRTCPL----------DEFQCNN 3663
Query: 221 TVLIALTKPTV-VIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTK-CVPK 278
T L KP E C + +N P RC KN + C+
Sbjct: 3664 T----LCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRC-------KNDRVCLWI 3712
Query: 279 DFQCDGDNDCGDWTDEDSC-PMVPGS--C-NAGEFKCNDGKCIPERWRCDNERDCADGGD 334
QCDG ++CGD TDE+ C P + C + EF C + +C+ RC+ DC DG D
Sbjct: 3713 GRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSD 3772
Query: 335 ELNCKPN-SIRNCSLDEYTCADR-RCV 359
E +C + + +C+ + C D RCV
Sbjct: 3773 EEDCSIDPKLTSCATNASICGDEARCV 3799
Score = 70.1 bits (164), Expect = 7e-11
Identities = 72/284 (25%), Positives = 122/284 (42%), Gaps = 24/284 (8%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRD-IDECMYEQDPVC-------SQTCSNTV 490
C++LC+ G ACAC G +LAED SCR+ +Y + + + + V
Sbjct: 2166 CQQLCLYRGRGQRACACAHG-MLAEDGASCREYAGYLLYSERTILKSIHLSDERNLNAPV 2224
Query: 491 GSFR-CGCMTGYI-LRPDERSCKPTGESPTLLFSN-RIG-IRQVWLTGDNYMSVVKGLHN 546
F M I L D R+ G + FS+ G I+Q+ G +++V+ + +
Sbjct: 2225 QPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIVENVGS 2284
Query: 547 AVALDYHYEKKLVFWSENNLRVI---RVAQMNT---KNMSDVIRWGLETPAGVAVDWIHD 600
L YH ++W+ I V Q + + + G + P +D +
Sbjct: 2285 VEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQN 2344
Query: 601 LLFWTDSGTRRVEV--ATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIER 658
L+FWT+ + + A L G+ L+ D+ P +A+ ++++D KIER
Sbjct: 2345 LMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSD-ATLDKIER 2403
Query: 659 ADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERA 702
+ DG R ++ E P GL + Y E I+W D ++RA
Sbjct: 2404 CEYDGSHRYVILKSEPVHPFGLAV-YGE-HIFWTDWVRRAVQRA 2445
Score = 64.1 bits (149), Expect = 4e-09
Identities = 73/260 (28%), Positives = 113/260 (43%), Gaps = 25/260 (9%)
Query: 1315 ERVLENACGTDNGGCSHLCLRSP-LGYTCACPTGMPF-EKSTTDQTPKKCKSHPEEFLIF 1372
E L + C +NGGCSH C +P G C+CP GM + T Q C H L
Sbjct: 1178 EGELCDQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKH----LKC 1233
Query: 1373 ATRGSITYISLESP--EQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTN 1430
+ + S++ E W V P E ++ D F + + IR I++
Sbjct: 1234 SQKCDQNKFSVKCSCYEGW-VLEPDGESCRSL------DPFKPFIIFSNRHEIRRIDLHK 1286
Query: 1431 MSESKTIISQKLETPNGLGVDWIANNIYWTD-NEHKVIEVARLDG---SSRKVLIT-GLT 1485
S ++ L L + +YWTD E K+ LD +S +V+I GL
Sbjct: 1287 GDYS--VLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLA 1344
Query: 1486 EPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYW 1545
P LA+ G +YW + IE + LDG+ R ++ D+ P + +D ++ L+W
Sbjct: 1345 TPEGLAVDWIAGNIYWVE-SNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFW 1403
Query: 1546 T--DALKDRIDTSDLNGQHR 1563
T DA RI+ + ++G R
Sbjct: 1404 TDWDASLPRIEAASMSGAGR 1423
Score = 60.9 bits (141), Expect = 4e-08
Identities = 61/229 (26%), Positives = 95/229 (41%), Gaps = 16/229 (6%)
Query: 680 LTIDYTESKIYWADA--KHHVIERAAFDGRDRRKVTTKGLPHPFALTL--FDDAIYWTDW 735
L DY E IYW D + +I R +G + + + GL +P L + +YW D
Sbjct: 3062 LDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDK 3121
Query: 736 HTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESKKP 795
+I N V +GL P R+ + LY D L +
Sbjct: 3122 GRDTIEVSKLNGAYRTVLVSSGLREP-----RALVVDVQNGYLYWT--DWGDHSLIGRIG 3174
Query: 796 IDSLDMVIPVET-IKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWP 854
+D + V+T I L D + I+W D +D I A L+GS++ ++ ++ P
Sbjct: 3175 MDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDI--P 3232
Query: 855 AGLAFDWITDKIYWTDGGTNRI-EVSKSDGSMRTLLAWDHIDKPRDIVV 902
A D +YWTD T I K+ G+ +TLL + +P D+ V
Sbjct: 3233 HIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLI-STLHRPMDLHV 3280
Score = 59.3 bits (137), Expect = 1e-07
Identities = 29/97 (29%), Positives = 43/97 (44%), Gaps = 7/97 (7%)
Query: 343 IRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAF 402
+ NC+ ++ C + +C+ W CD DC + DE C E + CRP + S
Sbjct: 3331 VSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDE---PPDCPE--FKCRPGQFQCSTGI 3385
Query: 403 RNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKC 439
C N +CDG DC DE C + ++ KC
Sbjct: 3386 --CTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKC 3420
Score = 56.4 bits (130), Expect = 9e-07
Identities = 27/78 (34%), Positives = 39/78 (50%), Gaps = 5/78 (6%)
Query: 263 CAEIDFECKNT-KCVPKDFQCDGDNDCGDWTDE--DSCPMVPGS-CNAGEFKC-NDGKCI 317
C+ F C++ C+ K ++CDG+ DC D +DE + CP C E C C+
Sbjct: 27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCV 86
Query: 318 PERWRCDNERDCADGGDE 335
P C+ +DC DG DE
Sbjct: 87 PMSRLCNGVQDCMDGSDE 104
Score = 51.6 bits (118), Expect = 2e-05
Identities = 19/33 (57%), Positives = 24/33 (72%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCDVVK 199
C T++C A W+CDG NDCGD+SDE +C VK
Sbjct: 2660 CERTSLCYAPSWVCDGANDCGDYSDERDCPGVK 2692
Score = 49.6 bits (113), Expect = 1e-04
Identities = 44/157 (28%), Positives = 64/157 (40%), Gaps = 16/157 (10%)
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGG---DELNCKPNSIRNCSLD 349
D +SC + P N G C D + + + C G D+L C+ + + D
Sbjct: 2473 DTNSCELSPCRINNGG--CQDLCLLTHQGHVNCS--CRGGRILQDDLTCRAVNSSCRAQD 2528
Query: 350 EYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRK 409
E+ CA+ C+ + CDGV C + DE + C+ SN CV+
Sbjct: 2529 EFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRR----CKKTFRQCSNG--RCVSNM 2582
Query: 410 HVCDGMKDCPRGDDEERCPLKRKCSAEE-KC-EKLCI 444
C+G DC G DE C K C E +C + CI
Sbjct: 2583 LWCNGADDCGDGSDEIPCN-KTACGVGEFRCRDGTCI 2618
Score = 44.8 bits (101), Expect = 0.003
Identities = 33/94 (35%), Positives = 38/94 (40%), Gaps = 9/94 (9%)
Query: 107 EGTEDDAGC-ITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDE---HE 162
+ D+A C I CL F C + CIP R R C E
Sbjct: 3400 QDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDE----RDCPEVTCAP 3455
Query: 163 NRTICHSTNVCIALEWLCDGDNDCGDFSDE-INC 195
N+ C T CI W+CD DNDC D SDE NC
Sbjct: 3456 NQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANC 3489
Score = 42.3 bits (95), Expect = 0.015
Identities = 27/86 (31%), Positives = 33/86 (38%), Gaps = 5/86 (5%)
Query: 110 EDDAGCI-TPCLKINFSCQISCTCIPMEK--RXXXXXXXXXXXXXXXXXRSCDEHENRTI 166
ED+ C C F C I+ CIP +C E R
Sbjct: 3443 EDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFR-- 3500
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDE 192
C + CI W CDG++DCGD SDE
Sbjct: 3501 CKDSGRCIPARWKCDGEDDCGDGSDE 3526
Score = 38.3 bits (85), Expect = 0.25
Identities = 18/58 (31%), Positives = 28/58 (48%), Gaps = 1/58 (1%)
Query: 422 DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQD 479
+D C L C+ LC+ T+ GH C+C G +L +D +CR ++ QD
Sbjct: 2472 NDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRIL-QDDLTCRAVNSSCRAQD 2528
Score = 36.3 bits (80), Expect = 1.00
Identities = 14/20 (70%), Positives = 14/20 (70%)
Query: 173 CIALEWLCDGDNDCGDFSDE 192
CI W CDGDNDC D SDE
Sbjct: 866 CIQERWKCDGDNDCLDNSDE 885
Score = 35.5 bits (78), Expect = 1.7
Identities = 13/26 (50%), Positives = 15/26 (57%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDE 192
C CI+ W CDG+ DC D SDE
Sbjct: 34 CRDQITCISKGWRCDGERDCPDGSDE 59
Score = 33.1 bits (72), Expect = 9.3
Identities = 38/152 (25%), Positives = 61/152 (40%), Gaps = 23/152 (15%)
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCT-NGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRN 404
C ++ C D C+L G +C+ G + +++C +CR Q+ A
Sbjct: 2482 CRINNGGCQDL-CLLTH---QGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFEC-ANGE 2536
Query: 405 CVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAED 464
C+N CDG+ C DE+ C++ +C+K +G C L
Sbjct: 2537 CINFSLTCDGVPHCKDKSDEK----PSYCNSR-RCKKTFRQCSNGR----CVSNMLW--- 2584
Query: 465 KYSCRDIDECMYEQDPV-CSQTCSNTVGSFRC 495
C D+C D + C++T VG FRC
Sbjct: 2585 ---CNGADDCGDGSDEIPCNKTACG-VGEFRC 2612
>AF058427-1|AAC64265.1| 4544|Homo sapiens lipoprotein receptor-related
protein protein.
Length = 4544
Score = 549 bits (1355), Expect = e-155
Identities = 318/908 (35%), Positives = 492/908 (54%), Gaps = 67/908 (7%)
Query: 800 DMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYL--NGSHQT--TIVDSNLIWPA 855
D + V +++ +ALD+ ++++WTDV +D I R L NG+ + ++ L P
Sbjct: 1288 DYSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPE 1347
Query: 856 GLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWG 915
GLA DWI IYW + ++IEV+K DG++RT L I+ PR I ++P G+++W+DW
Sbjct: 1348 GLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWD 1407
Query: 916 AS-PCIERADMDGGNRKKL--IFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTG 972
AS P IE A M G R+ + G WPNGL +D + RI W D + I A DG+G
Sbjct: 1408 ASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSG 1467
Query: 973 RTKLI---ENLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTG------------------ 1011
+++ E L HPF + LYG EV+WTDW T ++ ANK TG
Sbjct: 1468 HMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQV 1527
Query: 1012 --AKRRTLG---CGKN--NGGCSHLCLLKPGGR-SCACPIGIKLNKDGKTCADGPINYLI 1063
R+ + C N G CSHLCL+ SCACP +KL+KD TC + +L+
Sbjct: 1528 YHPSRQPMAPNPCEANGGQGPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYEFK-KFLL 1586
Query: 1064 FAHRVDIRVISLDVPYLIDVV-LPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLG 1122
+A +++IR + LD PY ++ +P + N +D D +YW+D + I+RA G
Sbjct: 1587 YARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFING 1646
Query: 1123 THVETVIGNGLHTADGIVIDSTGRKIYWT--DGGRNSIEVAELDGRNRKVLVWTGLDSPR 1180
T VETV+ L A G+ +D R ++WT D + I VA LDG + +V GL+ P
Sbjct: 1647 TGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPH 1705
Query: 1181 AIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDA 1240
+ +H G ++W+D I A+MDG+NR ++ + K P GLAID E +LYW +
Sbjct: 1706 GLVVHPLRGKLYWTD---GDNISMANMDGSNRTLLFSGQ-KGPVGLAIDFPESKLYWISS 1761
Query: 1241 KILTIESSDFDGHDRRTV---LSNVPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPI 1297
TI + DG + S + + I+G ++W D ++ + K + S +
Sbjct: 1762 GNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSV 1821
Query: 1298 VIRKNLEGLMDIR----AIQSERVLENACGTDNGGCSHLCL-RSPLGYTCACPTGMPFEK 1352
V+R + +M ++ +IQ + N C +NG CS LCL S +C C G
Sbjct: 1822 VLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRS 1881
Query: 1353 STTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDYHWDLKM 1412
+ C+ FL+++ I I L+ ++ D +PV + +D+H +
Sbjct: 1882 G-----QQACEG-VGSFLLYSVHEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDT 1935
Query: 1413 IFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARL 1472
I++ D+ L+ I S + + + +++ + G+ VDWIA NIYWTD VIEVARL
Sbjct: 1936 IYWVDMGLSTI-SRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARL 1994
Query: 1473 DGSSRKVLIT-GLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFP 1531
+GS R V+I+ GL +PRA+ + P KGYL+W++WG++P IERS LDG++R ++V V + +P
Sbjct: 1995 NGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWP 2054
Query: 1532 NGLTIDYKERRLYWTDALKDRIDTSDL-NGQHR-VQLVPDAKNPFGMTQFKDYIYWTD-- 1587
NG+++DY++ +LYW DA D+I+ DL G++R V L + + F ++ F+D+IYW+D
Sbjct: 2055 NGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRT 2114
Query: 1588 WYKKSIIRADKRTGKNITLIRTNLEMAM-EIKAVSADRQHGWNPCKESNGGCSHLCLFRG 1646
SI R K + +RT + + + +IK + DRQ G N C +NGGC LCL+RG
Sbjct: 2115 HANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRG 2174
Query: 1647 H-EYICAC 1653
+ CAC
Sbjct: 2175 RGQRACAC 2182
Score = 522 bits (1288), Expect = e-147
Identities = 358/1174 (30%), Positives = 579/1174 (49%), Gaps = 105/1174 (8%)
Query: 559 VFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTD--SGTRRVEVAT 616
++W E+NL I VA+++ + ++ +E P +A+D +LFWTD + R+E A+
Sbjct: 1358 IYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAAS 1417
Query: 617 LDGSKRAVL--VANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEI 674
+ G+ R + P + V + + W D + I A DG V+
Sbjct: 1418 MSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWID-ARSDAIYSARYDGSGHMEVLRGHE 1476
Query: 675 FWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYWTD 734
F + + ++YW D + + + +A V + PF L +Y
Sbjct: 1477 FLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQ-----VYHPS 1531
Query: 735 WHTKSISTVNKNTGMGI----------QTVHAGLNVPMDIH--SRSCEETPEKLLLYARR 782
+ + N G G +TV M +H + +C E +K LLYAR+
Sbjct: 1532 RQPMAPNPCEANGGQGPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYEF-KKFLLYARQ 1590
Query: 783 KDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSH 842
++R L++ P + + V I + LD+D + ++W+DV I RA++NG+
Sbjct: 1591 MEIRGVDLDA--PYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTG 1648
Query: 843 QTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNR--IEVSKSDGSMRTLLAWDHIDKPRDI 900
T+V ++L GLA DW++ ++WT TN+ I V++ DGS + + +++P +
Sbjct: 1649 VETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPHGL 1707
Query: 901 VVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGN 960
VV+P G +YW+D I A+MDG NR L GQ P GLA+D +++YW GN
Sbjct: 1708 VVHPLRGKLYWTD---GDNISMANMDGSNRTLLFSGQKG-PVGLAIDFPESKLYWISSGN 1763
Query: 961 KTIEYANLDGTGRTKLIENLPHPFG----LDLYGDEVFWTDWDTQSIQAANKDTGA---- 1012
TI NLDG+G ++I+ + G L + GD+++W D ++ + +K G+
Sbjct: 1764 HTINRCNLDGSG-LEVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVV 1822
Query: 1013 ---------------------KRRTLGCGKNNGGCSHLCL-LKPGGRSCACPIGIKLNKD 1050
+ T C NNG CS LCL RSC C G L +
Sbjct: 1823 LRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSL-RS 1881
Query: 1051 GKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNALGVDVDHSTGLIYWTDT 1110
G+ +G ++L+++ IR I LD D ++P+ A+G+D IYW D
Sbjct: 1882 GQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDM 1941
Query: 1111 GQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKV 1170
G I RA R T E V+ NG+ +GI +D IYWTD G + IEVA L+G R V
Sbjct: 1942 GLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYV 2001
Query: 1171 LVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDR 1230
++ GLD PRAI +H E GY+FW++WG +IER+ +DG R V+V+ I WPNG+++D
Sbjct: 2002 VISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWPNGISVDY 2061
Query: 1231 IEGRLYWNDAKILTIESSDFD-GHDRRTVL-SNVPYPYGIVIVGQHIYWTDWKTKA---L 1285
+G+LYW DA+ IE D + G +R VL SN + + + IYW+D +T A +
Sbjct: 2062 QDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSD-RTHANGSI 2120
Query: 1286 HRADKTNASDPIVIRKNL-EGLMDIRAIQSERVL-ENACGTDNGGCSHLCLRSPLGY-TC 1342
R K NA+D + +R + L DI+ +R N C NGGC LCL G C
Sbjct: 2121 KRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGRGQRAC 2180
Query: 1343 ACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTL-PVKE---V 1398
AC GM E + C+ + +L+++ R + I L + + P ++ +
Sbjct: 2181 ACAHGMLAEDGAS------CREY-AGYLLYSERTILKSIHLSDERNLNAPVQPFEDPEHM 2233
Query: 1399 KNTIAVDYHWDL-------KMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVD 1451
KN IA+ + + IF++D+ I+ IN + S TI+ + + + GL
Sbjct: 2234 KNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQIN-DDGSRRITIV-ENVGSVEGLAYH 2291
Query: 1452 WIANNIYWTDN-----EHKVIEVARLDGSSRKVLIT--GLTEPRALALFPAKGYLYWSDW 1504
+ +YWT ++ R R+ +IT G PRA L + ++W++W
Sbjct: 2292 RGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNW 2351
Query: 1505 GE-HPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHR 1563
E HP I R+ L G+ +++ D+ PNGL ID++ +LY++DA D+I+ + +G HR
Sbjct: 2352 NEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHR 2411
Query: 1564 -VQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNL-EMAMEIKAVS 1621
V L + +PFG+ + ++I+WTDW ++++ RA+K G N+ L+R ++ + M I AV+
Sbjct: 2412 YVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVA 2471
Query: 1622 ADRQH-GWNPCKESNGGCSHLCLFRGHEYI-CAC 1653
D +PC+ +NGGC LCL ++ C+C
Sbjct: 2472 NDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSC 2505
Score = 406 bits (999), Expect = e-112
Identities = 203/513 (39%), Positives = 291/513 (56%), Gaps = 17/513 (3%)
Query: 263 CAEIDFECKNTK-CVPKDFQCDGDNDCGDWTDEDSCP--MVPGSCNAGEFKCNDGKCIPE 319
C F C T CVP+ + CDGD DC D DE + +C+ EF C + +CIP+
Sbjct: 2774 CGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQNRQCIPK 2833
Query: 320 RWRCDNERDCADGGDEL-NCKPNSIRNCSLDEYTCADRRCVL-KTWLCDGVRDCTNGEDE 377
+ CD++RDCADG DE C+ C E+ CA+ RC+ + W CDG DC + DE
Sbjct: 2834 HFVCDHDRDCADGSDESPECE---YPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDE 2890
Query: 378 MNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAE- 436
C ++ C + ++ R CV +C+G DC DE C + S +
Sbjct: 2891 APKNPHCTSPEHKCNASSQFLCSSGR-CVAEALLCNGQDDCGDSSDERGCHINECLSRKL 2949
Query: 437 EKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCG 496
C + C G C C GF L +D +C D+DEC CSQ C NT GS++C
Sbjct: 2950 SGCSQDCEDLKIGFK-CRCRPGFRLKDDGRTCADVDECSTTFP--CSQRCINTHGSYKCL 3006
Query: 497 CMTGYILRP-DERSCKP-TGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHY 554
C+ GY R D SCK T E P L+F+NR +R++ L G NY + +GL+NAVALD+ Y
Sbjct: 3007 CVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDY 3066
Query: 555 EKKLVFWSENNLR--VIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRV 612
+++++W++ + +IR +N N+ + R GL P G+AVDW+ L+W D G +
Sbjct: 3067 REQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTI 3126
Query: 613 EVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYD 672
EV+ L+G+ R VLV++ L +PRA+ V + ++WTDWG + I R MDG R ++
Sbjct: 3127 EVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDT 3186
Query: 673 EIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYW 732
+I WPNGLT+DY +IYWADA+ IE A+ DG +R V ++ +PH FALTLF+D +YW
Sbjct: 3187 KITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYW 3246
Query: 733 TDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIH 765
TDW TKSI+ +K TG + + L+ PMD+H
Sbjct: 3247 TDWETKSINRAHKTTGTNKTLLISTLHRPMDLH 3279
Score = 386 bits (951), Expect = e-106
Identities = 197/522 (37%), Positives = 283/522 (54%), Gaps = 31/522 (5%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDE------DSCPMVPGSCNAGEFKCN-DGK 315
C+ F+C + +C+P+ + CDGDNDCGD++DE + PG C+ EF+C DG
Sbjct: 1015 CSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGL 1074
Query: 316 CIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADR-RCVLKTWLCDGVRDCTNG 374
CIP RWRCD + DC D DE +C+ + ++ C D RC+ K W+CDG DC +
Sbjct: 1075 CIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDN 1134
Query: 375 EDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE-ERCPLKRKC 433
DE NCE CRP H +N C+ +CDG DC G DE E C +C
Sbjct: 1135 SDEENCE------SLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCD---QC 1185
Query: 434 SAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGS 492
S C C C+CP+G L D ++C+ C CSQ C S
Sbjct: 1186 SLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLK--CSQKCDQNKFS 1243
Query: 493 FRCGCMTGYILRPDERSCKPTGE-SPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALD 551
+C C G++L PD SC+ P ++FSNR IR++ L +Y +V GL N +ALD
Sbjct: 1244 VKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALD 1303
Query: 552 YHYEKKLVFWSEN-NLRVIRVAQMNTKNMSD---VIRWGLETPAGVAVDWIHDLLFWTDS 607
+H + ++W++ ++ R ++ ++ VI++GL TP G+AVDWI ++W +S
Sbjct: 1304 FHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVES 1363
Query: 608 GTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPN-PKIERADMDGDKR 666
++EVA LDG+ R L+A D++ PRAIA+ P D ++FWTDW + P+IE A M G R
Sbjct: 1364 NLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGR 1423
Query: 667 KTVIYD--EIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTT--KGLPHPFA 722
+TV + WPNGLT+DY E +I W DA+ I A +DG +V + L HPFA
Sbjct: 1424 RTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFA 1483
Query: 723 LTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDI 764
+TL+ +YWTDW T +++ NK TG + V P D+
Sbjct: 1484 VTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDL 1525
Score = 330 bits (810), Expect = 4e-89
Identities = 207/645 (32%), Positives = 325/645 (50%), Gaps = 42/645 (6%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTCAD-GPIN-YLIFAHRVDIRVISLDVPYLIDV 1083
CS C C+C G L DG++C P ++IF++R +IR I L + D
Sbjct: 1233 CSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDL---HKGDY 1289
Query: 1084 VLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLG----THVETVIGNGLHTADGI 1139
+ +P L+N + +D S +YWTD + KI R L T E VI GL T +G+
Sbjct: 1290 SVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGL 1349
Query: 1140 VIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTS 1199
+D IYW + + IEVA+LDG R L+ ++ PRAIAL G +FW+DW S
Sbjct: 1350 AVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDAS 1409
Query: 1200 -AKIERADMDGNNRRVI--VDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRR 1256
+IE A M G RR + WPNGL +D +E R+ W DA+ I S+ +DG
Sbjct: 1410 LPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHM 1469
Query: 1257 TVLSN---VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQ 1313
VL + +P+ + + G +YWTDW+T L +A+K + V+++ D++
Sbjct: 1470 EVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYH 1529
Query: 1314 SER--VLENACGTD--NGGCSHLCL-RSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEE 1368
R + N C + G CSHLCL +CACP M K T C ++
Sbjct: 1530 PSRQPMAPNPCEANGGQGPCSHLCLINYNRTVSCACPHLMKLHKDNT-----TCYEF-KK 1583
Query: 1369 FLIFATRGSITYISLESP-EQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSIN 1427
FL++A + I + L++P + ++ V ++ N +DY + ++++D+ I+
Sbjct: 1584 FLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRA- 1642
Query: 1428 MTNMSESKTIISQKLETPNGLGVDWIANNIYWT--DNEHKVIEVARLDGSSRKVLITGLT 1485
N + +T++S L +GL VDW++ N++WT D K I VARLDGS + ++ GL
Sbjct: 1643 FINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVVQGLE 1702
Query: 1486 EPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYW 1545
+P L + P +G LYW+D G++ I + +DGS R ++ G P GL ID+ E +LYW
Sbjct: 1703 QPHGLVVHPLRGKLYWTD-GDN--ISMANMDGSNRTLLFSGQKG-PVGLAIDFPESKLYW 1758
Query: 1546 TDALKDRIDTSDLNGQHRVQLVPDAKNPFG----MTQFKDYIYWTDWYKKSIIRADKRTG 1601
+ I+ +L+G ++++ ++ G + D ++W D + + K G
Sbjct: 1759 ISSGNHTINRCNLDGS-GLEVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADG 1817
Query: 1602 KNITLIR--TNLEMAMEIKAVSADRQH-GWNPCKESNGGCSHLCL 1643
++R T L M M++ S H G NPC +NG CS LCL
Sbjct: 1818 SGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQLCL 1862
Score = 301 bits (740), Expect = 1e-80
Identities = 211/684 (30%), Positives = 338/684 (49%), Gaps = 60/684 (8%)
Query: 1024 GGCSHLCLLKPGGRSCACPIGIKLNKDGKTCA--DGPIN---YLIFAHRVDIRVISLDVP 1078
G CS LC G C C G L D ++C + P++ L+ A+ +I L
Sbjct: 158 GTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGA 217
Query: 1079 YLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTG------QRKIQRATRLGTHVE--TV-I 1129
+ + P + +D ++ + W G Q K R L V+ T+ I
Sbjct: 218 Q-VSTITPTST-RQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINI 275
Query: 1130 GNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYG 1189
LH + + ID Y+ D + I V +G L+ L +P+ IAL G
Sbjct: 276 SLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMG 335
Query: 1190 YMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSD 1249
+F++D+G K+ER DMDG NR +VD+KI +P+G+ +D + +YW DA + IE D
Sbjct: 336 KVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVD 395
Query: 1250 FDGHDRRTVLSN--VPYPYGIVIVGQHIYWTD-------WKTKALHRADKTNASD-PIVI 1299
++G R+T++ + + YG+ + ++Y T+ KT + R ++ N+++ +V
Sbjct: 396 YEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVI-RVNRFNSTEYQVVT 454
Query: 1300 RKNLEGLMDI-RAIQSERVLENACGTDN----GGCSHLCL--RSPLGYTCACPTGMPFEK 1352
R + G + I + RV +AC D GGCS +CL S TC C +G
Sbjct: 455 RVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGF---- 510
Query: 1353 STTDQTPKKCKSHPEE-FLIF--ATRGSITYISLESPEQWDVTLPVKEVKNTIAVDYHWD 1409
+ K CK E FL++ G I + + + + +P++ + N A+D+H +
Sbjct: 511 -SLGSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAE 569
Query: 1410 LKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDN-EHKVIE 1468
I++ D +I + +E +TI+ + G+ VDW+ +N+YWTD+ K I
Sbjct: 570 TGFIYFADTTSYLIGRQKIDG-TERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTIS 628
Query: 1469 VARLD--GSSRKVLITG-LTEPRALALFPAKGYLYWSDWGEHP------YIERSYLDGSQ 1519
VARL+ +RK LI G +T PRA+ + P G++YW+DW E P +ER+++DGS
Sbjct: 629 VARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSH 688
Query: 1520 RQIIV-QVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHR--VQLVPDAKNPFGM 1576
R I V + +PNGL++D RLYW DA DRI+T LNG R V P+ + FG+
Sbjct: 689 RDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGL 748
Query: 1577 TQFKDYIYWTDWYKKSIIRADKRTG---KNITLIRTNLEMAMEIKAVSADRQH-GWNPCK 1632
+Y++WT++ S+ R ++ G +TL+R+ EI+ A +Q G N C+
Sbjct: 749 CHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCR 808
Query: 1633 ESNGGCSHLCLFRGHEYICACPDD 1656
+NGGCS LCL CAC +D
Sbjct: 809 VNNGGCSSLCLATPGSRQCACAED 832
Score = 284 bits (696), Expect = 2e-75
Identities = 174/543 (32%), Positives = 266/543 (48%), Gaps = 38/543 (6%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
RC F+CK+ C+P ++CD D DC D +DE++C +C EF+CN+ C P W
Sbjct: 3612 RCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAW 3671
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDE-YTCA-DRRCVLKTWLCDGVRDCTNGEDEMN 379
+CD E DC D DE N + + C + + C DR C+ CDG +C +G DE +
Sbjct: 3672 KCDGEDDCGDNSDE-NPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEED 3730
Query: 380 CEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRK---CSAE 436
CE + +E L N + C++ C+ DC G DEE C + K C+
Sbjct: 3731 CEPPTAHTTHCKDKKEFLCRN--QRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATN 3788
Query: 437 EK-C--EKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSF 493
C E C+ T + A CAC GF + C+DI+EC+ + CSQ C+NT G
Sbjct: 3789 ASICGDEARCVRT-EKAAYCACRSGFHTVPGQPGCQDINECL--RFGTCSQLCNNTKGGH 3845
Query: 494 RCGCMTGYILRPDERSCKPTG-ESPTLLFSNRIGIRQVWLTGDN--YMSVVKGLHNA--V 548
C C ++ +CK G E L ++ IR ++ + Y +G +
Sbjct: 3846 LCSCARNFM--KTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGDESVRID 3903
Query: 549 ALDYHYEKKLVFWSENNLRVIR------VAQMNTKN---------MSDVIRWGLETPAGV 593
A+D H + V+W+ + I A T N ++ + GL+ P G+
Sbjct: 3904 AMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGI 3963
Query: 594 AVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPN 653
A+DW+ ++WTDSG +EVA + G R L++ +D+P AI V P ++W+DWG +
Sbjct: 3964 AIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNH 4023
Query: 654 PKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDR--RK 711
PKIE A MDG R+T++ D I WP GL +DY ++YWADAK VI +G D
Sbjct: 4024 PKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAA 4083
Query: 712 VTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEE 771
+ +GL HPF++ +F+D IY + + ++K + + GL+ D+ +
Sbjct: 4084 DSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHK 4143
Query: 772 TPE 774
PE
Sbjct: 4144 QPE 4146
Score = 253 bits (619), Expect = 5e-66
Identities = 136/335 (40%), Positives = 198/335 (59%), Gaps = 17/335 (5%)
Query: 1329 CSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEE--FLIFATRGSITYISLESP 1386
CS C+ + Y C C G + P CK+ +E FLIFA R + ++L+
Sbjct: 2992 CSQRCINTHGSYKCLCVEGY----APRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGS 3047
Query: 1387 EQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDL--NVIRSINMTNMSESKTIISQKLET 1444
+ TL + + N +A+D+ + +MI++TD+ ++IR +++ N S + + L
Sbjct: 3048 ---NYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHL-NGSNVQVLHRTGLSN 3103
Query: 1445 PNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLIT-GLTEPRALALFPAKGYLYWSD 1503
P+GL VDW+ N+YW D IEV++L+G+ R VL++ GL EPRAL + GYLYW+D
Sbjct: 3104 PDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTD 3163
Query: 1504 WGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHR 1563
WG+H I R +DGS R +IV + +PNGLT+DY R+YW DA +D I+ + L+G +R
Sbjct: 3164 WGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNR 3223
Query: 1564 -VQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAVSA 1622
V L D + F +T F+DY+YWTDW KSI RA K TG N TL+ + L M++ A
Sbjct: 3224 HVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHA 3283
Query: 1623 DRQHGW--NPCKESNGGCSHLCLFR-GHEYICACP 1654
RQ +PCK +NGGCS+LCL G + CACP
Sbjct: 3284 LRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACP 3318
Score = 249 bits (609), Expect = 8e-65
Identities = 236/838 (28%), Positives = 361/838 (43%), Gaps = 95/838 (11%)
Query: 301 PGSCNAGEFKCNDG-KCIPERWRCDNERDCADGGDELN--CKPNSIRNCSLDEYTCADRR 357
P +C+ +F C D CI + WRCD ERDC DG DE C + + C +E+ C
Sbjct: 24 PKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTE 83
Query: 358 -CVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKH--VCDG 414
CV + LC+GV+DC +G DE C E Q C +CV C
Sbjct: 84 LCVPMSRLCNGVQDCMDGSDE---GPHCRELQGNCS-----RLGCQHHCVPTLDGPTCYC 135
Query: 415 MKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
D + C +CS C +LC T DG C C G+LL D SC+ +E
Sbjct: 136 NSSFQLQADGKTCKDFDECSVYGTCSQLCTNT-DGSFICGCVEGYLLQPDNRSCKAKNEP 194
Query: 475 MYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGES---PTLLFSNRIG--IRQ 529
+ + N + ++ G I R S T+ + + +G Q
Sbjct: 195 VDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVH-VGDSAAQ 253
Query: 530 VWLTGDNYMSVVKGLHNAVALD-----YHYEKKLVFWSENNLRVI-----RVAQMNTKNM 579
L M +KG + ++ +H E+ + W N + R+ N
Sbjct: 254 TQLKCAR-MPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGD 312
Query: 580 SDVIRWGLE--TPAGVAVDWIHDLLFWTDSGT-RRVEVATLDGSKRAVLVANDLDKPRAI 636
+ V LE P G+A+D +F+TD G +VE +DG R LV + + P I
Sbjct: 313 TCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGI 372
Query: 637 AVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWP-NGLTI--DY---TESKIY 690
+ LV+W D IE D +G R+T+I + GLT+ +Y T S
Sbjct: 373 TLDLVSRLVYWAD-AYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNA 431
Query: 691 WADAKHHVIERAAFDGRDRRKVTT--KG----LPHPFALTLFDDAIYWTDWHTK-----S 739
A K VI F+ + + VT KG + H D + K
Sbjct: 432 NAQQKTSVIRVNRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSD 491
Query: 740 ISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKL-LLYARRKDLRLKQLESKKPIDS 798
I + + +G ++ D +SC++ +L L+Y + + ++ ++ +
Sbjct: 492 ICLLANSHKARTCRCRSGFSLGSD--GKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPD 549
Query: 799 LDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLA 858
M IP+E + + ALD+ ++ I++ D I R ++G+ + TI+ + G+A
Sbjct: 550 EHM-IPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVA 608
Query: 859 FDWITDKIYWTDGGTNR-IEVSKSDGSMRT--LLAWDHIDKPRDIVVNPEGGVMYWSDWG 915
DW+ D +YWTD G + I V++ + + +T L + PR IVV+P G MYW+DW
Sbjct: 609 VDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWE 668
Query: 916 ASP------CIERADMDGGNRKKLIFGQ-MTWPNGLALDLVHNRIYWTDGGNKTIEYANL 968
P +ERA MDG +R + + + WPNGL+LD+ R+YW D IE L
Sbjct: 669 EDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILL 728
Query: 969 DGTGRTKLIE--NLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTG--------------- 1011
+GT R + E L H FGL +G+ +FWT++ + S+ + G
Sbjct: 729 NGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPP 788
Query: 1012 --------AKRRTLG---CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGP 1058
A+++ +G C NNGGCS LCL PG R CAC L+ DG TC P
Sbjct: 789 IFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANP 846
Score = 246 bits (602), Expect = 6e-64
Identities = 130/331 (39%), Positives = 194/331 (58%), Gaps = 13/331 (3%)
Query: 1026 CSHLCLLKPGGRSCACPIGIK-LNKDGKTC--ADGPINYLIFAHRVDIRVISLDVPYLID 1082
CS C+ G C C G D +C +LIFA+R +R ++LD +
Sbjct: 2992 CSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGS---N 3048
Query: 1083 VVLPLPPLKNALGVDVDHSTGLIYWTD-TGQRKIQRATRL-GTHVETVIGNGLHTADGIV 1140
L L NA+ +D D+ +IYWTD T Q + R L G++V+ + GL DG+
Sbjct: 3049 YTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLA 3108
Query: 1141 IDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSA 1200
+D G +YW D GR++IEV++L+G R VLV +GL PRA+ + + GY++W+DWG +
Sbjct: 3109 VDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHS 3168
Query: 1201 KIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLS 1260
I R MDG++R VIVD KI WPNGL +D + R+YW DA+ IE + DG +R VLS
Sbjct: 3169 LIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLS 3228
Query: 1261 -NVPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDI---RAIQSER 1316
++P+ + + + ++YWTDW+TK+++RA KT ++ ++ L MD+ A++
Sbjct: 3229 QDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPD 3288
Query: 1317 VLENACGTDNGGCSHLCLRSP-LGYTCACPT 1346
V + C +NGGCS+LCL SP G+ CACPT
Sbjct: 3289 VPNHPCKVNNGGCSNLCLLSPGGGHKCACPT 3319
Score = 235 bits (576), Expect = 8e-61
Identities = 128/320 (40%), Positives = 176/320 (55%), Gaps = 34/320 (10%)
Query: 763 DIHSRSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNS 822
D HS E L++A R LR K +D + + + + +AVALD+D +
Sbjct: 3017 DPHSCKAVTDEEPFLIFANRYYLR------KLNLDGSNYTLLKQGLNNAVALDFDYREQM 3070
Query: 823 IFWTDV--EKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSK 880
I+WTDV + I R +LNGS+ + + L P GLA DW+ +YW D G + IEVSK
Sbjct: 3071 IYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSK 3130
Query: 881 SDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTW 940
+G+ RT+L + +PR +VV+ + G +YW+DWG I R MDG +R ++ ++TW
Sbjct: 3131 LNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITW 3190
Query: 941 PNGLALDLVHNRIYWTDGGNKTIEYANLDGTGR-TKLIENLPHPFGLDLYGDEVFWTDWD 999
PNGL LD V RIYW D IE+A+LDG+ R L +++PH F L L+ D V+WTDW+
Sbjct: 3191 PNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWE 3250
Query: 1000 TQSIQAANKDTGAKRRTL------------------------GCGKNNGGCSHLCLLKP- 1034
T+SI A+K TG + L C NNGGCS+LCLL P
Sbjct: 3251 TKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPG 3310
Query: 1035 GGRSCACPIGIKLNKDGKTC 1054
GG CACP L DG+TC
Sbjct: 3311 GGHKCACPTNFYLGSDGRTC 3330
Score = 206 bits (504), Expect = 4e-52
Identities = 152/492 (30%), Positives = 222/492 (45%), Gaps = 38/492 (7%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKC-NDGKCIPERW 321
C+E FEC+N +C+ K + CDG +DCGD +DE + +C F C C+PERW
Sbjct: 2734 CSEAQFECQNHRCISKQWLCDGSDDCGDGSDE-AAHCEGKTCGPSSFSCPGTHVCVPERW 2792
Query: 322 RCDNERDCADGGDE---LNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEM 378
CD ++DCADG DE C NS C E+ C +R+C+ K ++CD RDC +G DE
Sbjct: 2793 LCDGDKDCADGADESIAAGCLYNS--TCDDREFMCQNRQCIPKHFVCDHDRDCADGSDE- 2849
Query: 379 NCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKC-SAEE 437
S E + TC P E +N R +R+ CDG DC D + P C S E
Sbjct: 2850 ----SPECEYPTCGPSEFRCANG-RCLSSRQWECDGENDC--HDQSDEAPKNPHCTSPEH 2902
Query: 438 KC----EKLCITTYDGHAACACPMGFLLAE--DKYSCRDIDECMYEQDPVCSQTCSNTVG 491
KC + LC + A C + D+ C I+EC+ + CSQ C +
Sbjct: 2903 KCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCH-INECLSRKLSGCSQDCEDLKI 2961
Query: 492 SFRCGCMTGYILRPDERSCKPTGE-SPTLLFSNR-IGIRQVW--LTGDNYMSVVKGLHNA 547
F+C C G+ L+ D R+C E S T S R I + L + Y H+
Sbjct: 2962 GFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTHGSYKCLCVEGYAPRGGDPHSC 3021
Query: 548 VALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDS 607
A+ E L+F + LR + + N +++ GL + D+ +++WTD
Sbjct: 3022 KAVT-DEEPFLIFANRYYLRKLNLDGSN----YTLLKQGLNNAVALDFDYREQMIYWTDV 3076
Query: 608 GTR--RVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDK 665
T+ + L+GS VL L P +AV ++W D G IE + ++G
Sbjct: 3077 TTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKG-RDTIEVSKLNGAY 3135
Query: 666 RKTVIYDEIFWPNGLTIDYTESKIYWAD-AKHHVIERAAFDGRDRRKVTTKGLPHPFALT 724
R ++ + P L +D +YW D H +I R DG R + + P LT
Sbjct: 3136 RTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLT 3195
Query: 725 L--FDDAIYWTD 734
L + IYW D
Sbjct: 3196 LDYVTERIYWAD 3207
Score = 198 bits (484), Expect = 1e-49
Identities = 106/288 (36%), Positives = 160/288 (55%), Gaps = 9/288 (3%)
Query: 482 CSQTCSNTVGSFR-CGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSV 540
CSQ C T + R C C GY LR +++C+ G LL+S GIR + L ++
Sbjct: 1857 CSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGSF--LLYSVHEGIRGIPLDPNDKSDA 1914
Query: 541 ---VKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDW 597
V G AV +D+H E ++W + L I A+ + DV+ G+ G+AVDW
Sbjct: 1915 LVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDW 1974
Query: 598 IHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIE 657
I ++WTD G +EVA L+GS R V+++ LDKPRAI VHP +FWT+WG P+IE
Sbjct: 1975 IAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIE 2034
Query: 658 RADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFD-GRDRRKVTTKG 716
R+ +DG +R ++ I WPNG+++DY + K+YW DA+ IER + G +R V +
Sbjct: 2035 RSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSN 2094
Query: 717 LPHPFALTLFDDAIYWTD-WHTK-SISTVNKNTGMGIQTVHAGLNVPM 762
F++++F+D IYW+D H SI +K+ + G+ V +
Sbjct: 2095 NMDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQL 2142
Score = 191 bits (465), Expect = 2e-47
Identities = 174/615 (28%), Positives = 253/615 (41%), Gaps = 78/615 (12%)
Query: 158 CDEH---ENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIG 214
C +H +R C + N CI WLCDGDNDCG+ DE N ++ P S G
Sbjct: 890 CHQHTCPSDRFKCEN-NRCIPNRWLCDGDNDCGNSEDESNATC--SARTCPPNQFSCASG 946
Query: 215 DVITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEI-DFECKNT 273
I I+ T C LD+ RS + C + F C N
Sbjct: 947 RCIP-----ISWT-----------C---DLDDDCGDRSDESASCAYPTCFPLTQFTCNNG 987
Query: 274 KCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGG 333
+C+ +++CD DNDCGD +DE C SC++ +FKCN G+CIPE W CD + DC D
Sbjct: 988 RCININWRCDNDNDCGDNSDEAGC---SHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYS 1044
Query: 334 DE--LNCKPNSIR---NCSLDEYTC-ADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEED 387
DE NC + R C DE+ C D C+ W CDG DC + DE SCE
Sbjct: 1045 DETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEK----SCEGV 1100
Query: 388 QYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC------PLKRKCSAEEK-C- 439
+ C P C+++ VCDG DC DEE C P C+ C
Sbjct: 1101 THVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCL 1160
Query: 440 --EKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVG-SFRCG 496
+KLC DG+ C +++ C D+C CS CS G C
Sbjct: 1161 PPDKLC----DGNDDCGDG-----SDEGELC---DQCSLNNGG-CSHNCSVAPGEGIVCS 1207
Query: 497 CMTGYILRPDERSCKPTGE-SPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYE 555
C G L PD +C+ + L S + + + Y V
Sbjct: 1208 CPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPF 1267
Query: 556 KKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVA 615
K + +S N IR ++ + S V+ GL + L+WTD ++
Sbjct: 1268 KPFIIFS--NRHEIRRIDLHKGDYS-VLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRG 1324
Query: 616 TL--DGSKRA--VLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIY 671
L +G+ + V++ L P +AV ++W + + +IE A +DG R T++
Sbjct: 1325 KLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLD-QIEVAKLDGTLRTTLLA 1383
Query: 672 DEIFWPNGLTIDYTESKIYWA--DAKHHVIERAAFDGRDRRKVTTK----GLPHPFALTL 725
+I P + +D + ++W DA IE A+ G RR V + G P+ +
Sbjct: 1384 GDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDY 1443
Query: 726 FDDAIYWTDWHTKSI 740
+ I W D + +I
Sbjct: 1444 LEKRILWIDARSDAI 1458
Score = 180 bits (438), Expect = 4e-44
Identities = 156/549 (28%), Positives = 252/549 (45%), Gaps = 63/549 (11%)
Query: 559 VFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTR-RVEVATL 617
++W++ VI VA++N VI GL+ P + V LFWT+ G R+E + L
Sbjct: 1979 IYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRL 2038
Query: 618 DGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMD-GDKRKTVIYDEIFW 676
DG++R VLV + P I+V D ++W D KIER D++ G+ R+ V+
Sbjct: 2039 DGTERVVLVNVSISWPNGISVDYQDGKLYWCD-ARTDKIERIDLETGENREVVLSSNNM- 2096
Query: 677 PNGLTIDYTESKIYWADAKHH--VIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYWTD 734
+ ++ E IYW+D H I+R + D G+ + L D ++ D
Sbjct: 2097 -DMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGI----GVQLKDIKVFNRD 2151
Query: 735 WHTKSISTVNKNTGMGIQTVHAG--------LNVPMDIHSRSCEETPEKLLLYARRKDLR 786
+ N G ++ G + + SC E LLY+ R L+
Sbjct: 2152 RQKGTNVCAVANGGCQQLCLYRGRGQRACACAHGMLAEDGASCREYAG-YLLYSERTILK 2210
Query: 787 LKQLESKKPIDS-LDMVIPVETIKSAVALDWDQKS-------NSIFWTDVEKDTINRAYL 838
L ++ +++ + E +K+ +AL +D ++ N IF++D+ I +
Sbjct: 2211 SIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQIND 2270
Query: 839 NGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSM------RTLLAWD 892
+GS + TIV+ N+ GLA+ D +YWT T+ I D + T++
Sbjct: 2271 DGSRRITIVE-NVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMS 2329
Query: 893 HIDKPRDIVVNPEGGVMYWSDWGAS-PCIERADMDGGNRKKLIFGQMTWPNGLALDLVHN 951
D PR V++ +M+W++W P I RA + G N LI + PNGLA+D
Sbjct: 2330 GDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAE 2389
Query: 952 RIYWTDGGNKTIEYANLDGTGRTKLIENLP-HPFGLDLYGDEVFWTDWDTQSIQAANKDT 1010
++Y++D IE DG+ R ++++ P HPFGL +YG+ +FWTDW +++Q ANK
Sbjct: 2390 KLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHV 2449
Query: 1011 GAKRRTLG------------------------CGKNNGGCSHLCLLKPGGR-SCACPIGI 1045
G+ + L C NNGGC LCLL G +C+C G
Sbjct: 2450 GSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCR-GG 2508
Query: 1046 KLNKDGKTC 1054
++ +D TC
Sbjct: 2509 RILQDDLTC 2517
Score = 173 bits (422), Expect = 4e-42
Identities = 99/297 (33%), Positives = 142/297 (47%), Gaps = 34/297 (11%)
Query: 169 STNVCIALEWLCDGDNDCGDFSDEINCDV----------VKTSLLVPS---ANASLNIGD 215
ST +C ++CDGDNDC D SDE NCD+ T+ +P N N GD
Sbjct: 3382 STGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGD 3441
Query: 216 VITN---PTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVEL--MRCAEIDFEC 270
P V A + I D + ++P M C +F C
Sbjct: 3442 GEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRC 3501
Query: 271 KNT-KCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDC 329
K++ +C+P ++CDG++DCGD +DE +C +F+C + +C+P RW+CD + DC
Sbjct: 3502 KDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDC 3561
Query: 330 ADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQY 389
D DE +C P R CS E++CA+ RC+ W CDG DC +G DE +C C+ DQ+
Sbjct: 3562 GDNSDEESCTP---RPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQF 3618
Query: 390 TCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPL-KRKCSAEE-KCEK-LC 443
C+ +C+ + CD DC G DEE C R C +E +C LC
Sbjct: 3619 QCKS---------GHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLC 3666
Score = 164 bits (399), Expect = 2e-39
Identities = 108/352 (30%), Positives = 166/352 (47%), Gaps = 33/352 (9%)
Query: 1327 GGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEF--LIFATRGSITYISLE 1384
G CS LC + G+ C+C F K T CK+ E+ L A I +
Sbjct: 3832 GTCSQLCNNTKGGHLCSCARN--FMK-----THNTCKAEGSEYQVLYIADDNEIRSLFPG 3884
Query: 1385 SPEQ-WDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVI--RSINM----TNMSESKTI 1437
P ++ E A+D H +++T+ I RS+ T + +
Sbjct: 3885 HPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQ 3944
Query: 1438 ISQK--------LETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITGLT-EPR 1488
I + L+ P G+ +DW+A N+YWTD+ VIEVA++ G +RK LI+G+ EP
Sbjct: 3945 IDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPH 4004
Query: 1489 ALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDA 1548
A+ + P +G +YWSDWG HP IE + +DG+ R+ +VQ ++ +P GL +DY RLYW DA
Sbjct: 4005 AIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADA 4064
Query: 1549 LKDRIDTSDLNGQHRVQLVPDAK----NPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNI 1604
I + LNG + + D+K +PF + F+DYIY + + + K +
Sbjct: 4065 KLSVIGSIRLNGTDPI-VAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPL 4123
Query: 1605 TLIRTNLEMAMEIKAVSADRQ-HGWNPCKESNGGCSHLCLFRGHEYICACPD 1655
+ L A ++ +Q NPC C LCL +C CP+
Sbjct: 4124 VNLTGGLSHASDVVLYHQHKQPEVTNPCDRKK--CEWLCLLSPSGPVCTCPN 4173
Score = 159 bits (385), Expect = 1e-37
Identities = 112/360 (31%), Positives = 153/360 (42%), Gaps = 29/360 (8%)
Query: 1024 GGCSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGP-INYLIFAHRVDIRVISLDVPY-L 1080
G CS LC GG C+C K TC A+G L A +IR + P+
Sbjct: 3832 GTCSQLCNNTKGGHLCSCARNFM--KTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSA 3889
Query: 1081 IDVVLPLPPLKNALGVDVDHSTGLIYWTD------------------TGQRKIQRATRLG 1122
+ +DV G +YWT+ T R ++ R
Sbjct: 3890 YEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGV 3949
Query: 1123 THVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAI 1182
TH+ +GL GI ID +YWTD GR+ IEVA++ G NRK L+ +D P AI
Sbjct: 3950 THLNI---SGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAI 4006
Query: 1183 ALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKI 1242
+ G M+WSDWG KIE A MDG R +V + I+WP GLA+D RLYW DAK+
Sbjct: 4007 VVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKL 4066
Query: 1243 LTIESSDFDGHDRRTVLSN---VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVI 1299
I S +G D + + +P+ I + +IY + + + K S + +
Sbjct: 4067 SVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNL 4126
Query: 1300 RKNLEGLMDIRAIQSERVLENACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTP 1359
L D+ + E D C LCL SP G C CP G + T P
Sbjct: 4127 TGGLSHASDVVLYHQHKQPEVTNPCDRKKCEWLCLLSPSGPVCTCPNGKRLDNGTCVPVP 4186
Score = 137 bits (332), Expect = 3e-31
Identities = 100/336 (29%), Positives = 145/336 (43%), Gaps = 42/336 (12%)
Query: 762 MDIHSRSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSN 821
M H+ E E +LY D ++ L P + + + A+D K+
Sbjct: 3854 MKTHNTCKAEGSEYQVLYIA-DDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHVKAG 3912
Query: 822 SIFWTDVEKDTINRAYL--------NGSHQ-------TTIVDSNLIWPAGLAFDWITDKI 866
++WT+ TI+ L + H+ T + S L P G+A DW+ +
Sbjct: 3913 RVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNV 3972
Query: 867 YWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMD 926
YWTD G + IEV++ G R L ID+P IVV+P G MYWSDWG P IE A MD
Sbjct: 3973 YWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMD 4032
Query: 927 GGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN---LPHP 983
G R+ L+ + WP GLA+D + R+YW D I L+GT ++ L HP
Sbjct: 4033 GTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHP 4092
Query: 984 FGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTLGCGKNNGG------------------ 1025
F +D++ D ++ + + +K + L G ++
Sbjct: 4093 FSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVTNPCD 4152
Query: 1026 ---CSHLCLLKPGGRSCACPIGIKLNKDGKTCADGP 1058
C LCLL P G C CP G +L D TC P
Sbjct: 4153 RKKCEWLCLLSPSGPVCTCPNGKRL--DNGTCVPVP 4186
Score = 136 bits (330), Expect = 5e-31
Identities = 90/261 (34%), Positives = 122/261 (46%), Gaps = 33/261 (12%)
Query: 169 STNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTK 228
S C++ C+G +DCGD SDEI C+ KT+ V G I N +
Sbjct: 2574 SNGRCVSNMLWCNGADDCGDGSDEIPCN--KTACGVGEFRC--RDGTCIGNSS------- 2622
Query: 229 PTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFE-CKNTK-CVPKDFQCDGDN 286
R F + + N +T + + F+ C+ T C + CDG N
Sbjct: 2623 -----RCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGAN 2677
Query: 287 DCGDWTDEDSCPMVPGS-CNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRN 345
DCGD++DE CP V C F C G+CIP W CD E DC G DE +C +
Sbjct: 2678 DCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCN----KF 2733
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDE-MNCE-VSCEEDQYTCRPQEHLMSNAFR 403
CS ++ C + RC+ K WLCDG DC +G DE +CE +C ++C P H+
Sbjct: 2734 CSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSC-PGTHV------ 2786
Query: 404 NCVNRKHVCDGMKDCPRGDDE 424
CV + +CDG KDC G DE
Sbjct: 2787 -CVPERWLCDGDKDCADGADE 2806
Score = 132 bits (318), Expect = 1e-29
Identities = 87/278 (31%), Positives = 135/278 (48%), Gaps = 16/278 (5%)
Query: 482 CSQTCS-NTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSV 540
CS C N + C C L D +C + LL++ ++ IR V L Y +
Sbjct: 1549 CSHLCLINYNRTVSCACPHLMKLHKDNTTCYEFKKF--LLYARQMEIRGVDLDAPYYNYI 1606
Query: 541 VK----GLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVD 596
+ + N LDY ++ V+WS+ + I+ A +N + V+ L G+AVD
Sbjct: 1607 ISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVD 1666
Query: 597 WIHDLLFWT--DSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNP 654
W+ LFWT D+ +++ VA LDGS + +V L++P + VHP ++WTD G N
Sbjct: 1667 WVSRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPHGLVVHPLRGKLYWTD-GDN- 1723
Query: 655 KIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTT 714
I A+MDG R T+++ P GL ID+ ESK+YW + +H I R DG +
Sbjct: 1724 -ISMANMDGSNR-TLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDA 1781
Query: 715 --KGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMG 750
L AL + D ++W D ++ + T +K G G
Sbjct: 1782 MRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSG 1819
Score = 128 bits (310), Expect = 1e-28
Identities = 71/197 (36%), Positives = 96/197 (48%), Gaps = 14/197 (7%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
+C +F C N++C+ + ++CDGDNDC D +DE +C + FKC + +CIP RW
Sbjct: 853 QCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRW 912
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCE 381
CD + DC + DE N S R C ++++CA RC+ +W CD DC + DE
Sbjct: 913 LCDGDNDCGNSEDESNA-TCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDE---S 968
Query: 382 VSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE-KCE 440
SC TC P N R C+N CD DC DE C CS+ + KC
Sbjct: 969 ASCAYP--TCFPLTQFTCNNGR-CININWRCDNDNDCGDNSDEAGC--SHSCSSTQFKCN 1023
Query: 441 K-LCIT---TYDGHAAC 453
CI T DG C
Sbjct: 1024 SGRCIPEHWTCDGDNDC 1040
Score = 125 bits (301), Expect = 2e-27
Identities = 64/182 (35%), Positives = 94/182 (51%), Gaps = 17/182 (9%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDE-DSCPMVPGSCNAGEFKCNDGKCIPERW 321
C F CKN KC+P ++CD ++DCGD +DE CP C G+F+C+ G C +
Sbjct: 3334 CTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEF--KCRPGQFQCSTGICTNPAF 3391
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNC 380
CD + DC D DE NC I C ++ C + RC+ + C+G +C +GEDE +C
Sbjct: 3392 ICDGDNDCQDNSDEANC---DIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDC 3448
Query: 381 -EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE-K 438
EV+C +Q+ C + + C+ R VCD DC G DE + C +E +
Sbjct: 3449 PEVTCAPNQFQC--------SITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFR 3500
Query: 439 CE 440
C+
Sbjct: 3501 CK 3502
Score = 124 bits (298), Expect = 4e-27
Identities = 88/281 (31%), Positives = 120/281 (42%), Gaps = 43/281 (15%)
Query: 173 CIALEWLCDGDNDCGDFSDE-INCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTV 231
CI W CD ++DCGD SDE +C K + G + TNP +
Sbjct: 3346 CIPFWWKCDTEDDCGDHSDEPPDCPEFKCR----PGQFQCSTG-ICTNPAFICDGDNDCQ 3400
Query: 232 VIRYESFC-AKKALDNAANPRSTWNQPVELMRC--------AEIDFECKNTKCVPKDFQ- 281
E+ C L + +T + RC E + +C C P FQ
Sbjct: 3401 DNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQC 3460
Query: 282 ------------CDGDNDCGDWTDED-SCPMVPGSCNAGEFKCND-GKCIPERWRCDNER 327
CD DNDC D +DE +C + +C EF+C D G+CIP RW+CD E
Sbjct: 3461 SITKRCIPRVWVCDRDNDCVDGSDEPANCTQM--TCGVDEFRCKDSGRCIPARWKCDGED 3518
Query: 328 DCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV-SCEE 386
DC DG DE + + R C ++ C + RCV W CD DC + DE +C C E
Sbjct: 3519 DCGDGSDEPKEECDE-RTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSE 3577
Query: 387 DQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC 427
+++C A C+ + CDG DC G DE+ C
Sbjct: 3578 SEFSC---------ANGRCIAGRWKCDGDHDCADGSDEKDC 3609
Score = 123 bits (297), Expect = 5e-27
Identities = 82/271 (30%), Positives = 122/271 (45%), Gaps = 26/271 (9%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALT-KPTV 231
CI C+ DC D SDE+NC S + L + V+ P +L P+
Sbjct: 2617 CIGNSSRCNQFVDCEDASDEMNCSATDCS-----SYFRLGVKGVLFQPCERTSLCYAPSW 2671
Query: 232 VIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDW 291
V + C + D P V+ RC F C + +C+P + CD ++DC
Sbjct: 2672 VCDGANDCGDYS-DERDCPG------VKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHG 2724
Query: 292 TDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDE-LNCKPNSIRNCSLDE 350
DE C C+ +F+C + +CI ++W CD DC DG DE +C+ + C
Sbjct: 2725 EDETHCNKF---CSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEG---KTCGPSS 2778
Query: 351 YTCADRR-CVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRK 409
++C CV + WLCDG +DC +G DE + C + TC +E + N R C+ +
Sbjct: 2779 FSCPGTHVCVPERWLCDGDKDCADGADE-SIAAGCLYNS-TCDDREFMCQN--RQCIPKH 2834
Query: 410 HVCDGMKDCPRGDDEE-RCPLKRKCSAEEKC 439
VCD +DC G DE C +E +C
Sbjct: 2835 FVCDHDRDCADGSDESPECEYPTCGPSEFRC 2865
Score = 118 bits (283), Expect = 3e-25
Identities = 64/183 (34%), Positives = 95/183 (51%), Gaps = 22/183 (12%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKC-NDGKCIPER 320
+C F+C C F CDGDNDC D +DE +C + C +FKC N +CIP
Sbjct: 3373 KCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDI--HVCLPSQFKCTNTNRCIPGI 3430
Query: 321 WRCDNERDCADGGDELNCKPNSIRNCSLDEYTCA-DRRCVLKTWLCDGVRDCTNGEDE-M 378
+RC+ + +C DG DE +C P C+ +++ C+ +RC+ + W+CD DC +G DE
Sbjct: 3431 FRCNGQDNCGDGEDERDC-PEV--TCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPA 3487
Query: 379 NC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE 437
NC +++C D++ C+ C+ + CDG DC G DE K +C E
Sbjct: 3488 NCTQMTCGVDEFRCKDS--------GRCIPARWKCDGEDDCGDGSDEP----KEECD-ER 3534
Query: 438 KCE 440
CE
Sbjct: 3535 TCE 3537
Score = 111 bits (268), Expect = 2e-23
Identities = 86/319 (26%), Positives = 144/319 (45%), Gaps = 30/319 (9%)
Query: 482 CSQTCS-NTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSV 540
C Q C G C C G +L D SC+ + LL+S R ++ + L+ + ++
Sbjct: 2166 CQQLCLYRGRGQRACACAHG-MLAEDGASCREY--AGYLLYSERTILKSIHLSDERNLNA 2222
Query: 541 V-------KGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSD------VIRWGL 587
+ + N +AL + Y + N + + N + ++D I +
Sbjct: 2223 PVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIVENV 2282
Query: 588 ETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSK------RAVLVANDLDKPRAIAVHPG 641
+ G+A D L+WT T + T+D ++ V+ + D PRA +
Sbjct: 2283 GSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDEC 2342
Query: 642 DALVFWTDWGP-NPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIE 700
L+FWT+W +P I RA + G T+I +I PNGL ID+ K+Y++DA IE
Sbjct: 2343 QNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIE 2402
Query: 701 RAAFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGL-N 759
R +DG R + HPF L ++ + I+WTDW +++ NK+ G ++ + +
Sbjct: 2403 RCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQ 2462
Query: 760 VPMDI-----HSRSCEETP 773
PM I + SCE +P
Sbjct: 2463 QPMGIIAVANDTNSCELSP 2481
Score = 104 bits (250), Expect = 3e-21
Identities = 68/236 (28%), Positives = 99/236 (41%), Gaps = 24/236 (10%)
Query: 264 AEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRC 323
A+ +FEC N +C+ CDG C D +DE C +C++G+C+ C
Sbjct: 2526 AQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWC 2585
Query: 324 DNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVS 383
+ DC DG DE+ C + C + E+ C D C+ + C+ DC + DEMNC +
Sbjct: 2586 NGADDCGDGSDEIPCNKTA---CGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSAT 2642
Query: 384 CEEDQYTCRPQEHLMSNAFRN--CVNRKHVCDGMKDCPRGDDEERCP-LKRKCSAEEKCE 440
+ + L R C VCDG DC DE CP +KR
Sbjct: 2643 DCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKR--------- 2693
Query: 441 KLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV-CSQTCSNTVGSFRC 495
C Y ACP G + ++C D+C + +D C++ CS F C
Sbjct: 2694 PRCPLNY-----FACPSGRCIPM-SWTCDKEDDCEHGEDETHCNKFCSE--AQFEC 2741
Score = 104 bits (249), Expect = 3e-21
Identities = 65/196 (33%), Positives = 91/196 (46%), Gaps = 24/196 (12%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
RC + +C N +CV C+G +DCGD +DE C +C GEF+C DG CI
Sbjct: 2565 RCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKT--ACGVGEFRCRDGTCIGNSS 2622
Query: 322 RCDNERDCADGGDELNCKPNSIRNCS----------LDEYTCADRRCVLKTWLCDGVRDC 371
RC+ DC D DE+NC S +CS L + C +W+CDG DC
Sbjct: 2623 RCNQFVDCEDASDEMNC---SATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDC 2679
Query: 372 TNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKR 431
+ DE +C + C P + + R C+ CD DC G+DE C +
Sbjct: 2680 GDYSDERDCP---GVKRPRC-PLNYFACPSGR-CIPMSWTCDKEDDCEHGEDETHC--NK 2732
Query: 432 KCS-AEEKCEK-LCIT 445
CS A+ +C+ CI+
Sbjct: 2733 FCSEAQFECQNHRCIS 2748
Score = 101 bits (242), Expect = 2e-20
Identities = 49/128 (38%), Positives = 60/128 (46%), Gaps = 8/128 (6%)
Query: 301 PGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVL 360
P C GEF C + +CI ERW+CD + DC D DE + C D + C + RC+
Sbjct: 851 PPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQ-HTCPSDRFKCENNRCIP 909
Query: 361 KTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDC-P 419
WLCDG DC N EDE N S TC P + S A C+ CD DC
Sbjct: 910 NRWLCDGDNDCGNSEDESNATCSAR----TCPPNQ--FSCASGRCIPISWTCDLDDDCGD 963
Query: 420 RGDDEERC 427
R D+ C
Sbjct: 964 RSDESASC 971
Score = 93.5 bits (222), Expect = 6e-18
Identities = 77/288 (26%), Positives = 126/288 (43%), Gaps = 16/288 (5%)
Query: 1025 GCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPY---LI 1081
GCS C G C C G +L DG+TCAD ++ R I+ Y +
Sbjct: 2951 GCSQDCEDLKIGFKCRCRPGFRLKDDGRTCAD--VDECSTTFPCSQRCINTHGSYKCLCV 3008
Query: 1082 DVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVI 1141
+ P ++ D LI+ R R L T++ GL+ A +
Sbjct: 3009 EGYAPRGGDPHSCKAVTDEEPFLIF----ANRYYLRKLNLDGSNYTLLKQGLNNAVALDF 3064
Query: 1142 DSTGRKIYWTD--GGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTS 1199
D + IYWTD + I L+G N +VL TGL +P +A+ + G ++W D G
Sbjct: 3065 DYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRD 3124
Query: 1200 AKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFDGHDRRTV 1258
IE + ++G R V+V + ++ P L +D G LYW D I DG R +
Sbjct: 3125 T-IEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVI 3183
Query: 1259 L-SNVPYPYGIVI--VGQHIYWTDWKTKALHRADKTNASDPIVIRKNL 1303
+ + + +P G+ + V + IYW D + + A ++ +V+ +++
Sbjct: 3184 VDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDI 3231
Score = 92.7 bits (220), Expect = 1e-17
Identities = 54/188 (28%), Positives = 83/188 (44%), Gaps = 27/188 (14%)
Query: 303 SCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKT 362
+C A +F C + KCIP W+CD E DC D DE P C ++ C+ C
Sbjct: 3333 NCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEF--KCRPGQFQCSTGICTNPA 3390
Query: 363 WLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGD 422
++CDG DC + DE NC++ + C P + +N R C+ C+G +C G+
Sbjct: 3391 FICDGDNDCQDNSDEANCDI------HVCLPSQFKCTNTNR-CIPGIFRCNGQDNCGDGE 3443
Query: 423 DEERC------PLKRKCSAEEKC---------EKLCITTYDGHAACACPMGFLLAEDKYS 467
DE C P + +CS ++C + C+ D A C D++
Sbjct: 3444 DERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCT---QMTCGVDEFR 3500
Query: 468 CRDIDECM 475
C+D C+
Sbjct: 3501 CKDSGRCI 3508
Score = 91.1 bits (216), Expect = 3e-17
Identities = 79/296 (26%), Positives = 140/296 (47%), Gaps = 21/296 (7%)
Query: 1019 CGKNNGGCSHLCLLKPG-GRSCACPIGIKLNKDGKTC--ADGPINYLIFAHRVDIRVISL 1075
C NNGGCSH C + PG G C+CP+G++L D TC +L + + D S+
Sbjct: 1185 CSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSV 1244
Query: 1076 DVPYLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHT 1135
VL P ++ +D +I+ + + +I+R L +V+ GL
Sbjct: 1245 KCSCYEGWVLE-PDGESCRSLD-PFKPFIIF---SNRHEIRRID-LHKGDYSVLVPGLRN 1298
Query: 1136 ADGIVIDSTGRKIYWTDGGRNSIEVAEL--DG--RNRKVLVWTGLDSPRAIALHYEYGYM 1191
+ + +YWTD + I +L +G + +V++ GL +P +A+ + G +
Sbjct: 1299 TIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNI 1358
Query: 1192 FWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWN--DAKILTIESSD 1249
+W + +IE A +DG R ++ I+ P +A+D +G L+W DA + IE++
Sbjct: 1359 YWVE-SNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAAS 1417
Query: 1250 FDGHDRRTV---LSNVPYPYGIVI--VGQHIYWTDWKTKALHRADKTNASDPIVIR 1300
G RRTV + +P G+ + + + I W D ++ A++ A + V+R
Sbjct: 1418 MSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLR 1473
Score = 87.8 bits (208), Expect = 3e-16
Identities = 71/261 (27%), Positives = 112/261 (42%), Gaps = 24/261 (9%)
Query: 91 KAIDVIHTDPDDGPLNEGTEDDAGCITP-CLKIN-FSCQISCTCIPMEKRXXXXXXXXXX 148
+ I + T D + +++ A C P C + F+C + CI + R
Sbjct: 947 RCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCN-NGRCININWRCDNDNDCGDN 1005
Query: 149 XXXXXXXRSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSAN 208
SC + + C+S CI W CDGDNDCGD+SDE + + + P
Sbjct: 1006 SDEAGCSHSCSSTQFK--CNSGR-CIPEHWTCDGDNDCGDYSDETHANCTNQATRPP--- 1059
Query: 209 ASLNIGDVITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDF 268
G T+ L + +R+ +D +++ +S + V + + F
Sbjct: 1060 -----GGCHTD-EFQCRLDGLCIPLRWRCDGDTDCMD-SSDEKSC--EGVTHVCDPSVKF 1110
Query: 269 ECKNT-KCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKC--NDGKCIPERWRCDN 325
CK++ +C+ K + CDGDNDC D +DE++C + +C C N C+P CD
Sbjct: 1111 GCKDSARCISKAWVCDGDNDCEDNSDEENCESL--ACRPPSHPCANNTSVCLPPDKLCDG 1168
Query: 326 ERDCADGGDELN-CKPNSIRN 345
DC DG DE C S+ N
Sbjct: 1169 NDDCGDGSDEGELCDQCSLNN 1189
Score = 83.4 bits (197), Expect = 7e-15
Identities = 70/266 (26%), Positives = 122/266 (45%), Gaps = 18/266 (6%)
Query: 685 TESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLF--DDAIYWTDWHTKS--I 740
T+ + + A + + + DG + + +GL + AL + IYWTD T+ I
Sbjct: 3025 TDEEPFLIFANRYYLRKLNLDGSNYT-LLKQGLNNAVALDFDYREQMIYWTDVTTQGSMI 3083
Query: 741 STVNKNTGMGIQTVH-AGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESKKPIDSL 799
++ N G +Q +H GL+ P + + + L + +D +E K +
Sbjct: 3084 RRMHLN-GSNVQVLHRTGLSNPDGL---AVDWVGGNLYWCDKGRDT----IEVSKLNGAY 3135
Query: 800 DMVIPVETIKSAVALDWDQKSNSIFWTDV-EKDTINRAYLNGSHQTTIVDSNLIWPAGLA 858
V+ ++ AL D ++ ++WTD + I R ++GS ++ IVD+ + WP GL
Sbjct: 3136 RTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLT 3195
Query: 859 FDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASP 918
D++T++IYW D + IE + DGS R ++ I P + +YW+DW +
Sbjct: 3196 LDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDI--PHIFALTLFEDYVYWTDW-ETK 3252
Query: 919 CIERADMDGGNRKKLIFGQMTWPNGL 944
I RA G K L+ + P L
Sbjct: 3253 SINRAHKTTGTNKTLLISTLHRPMDL 3278
Score = 78.6 bits (185), Expect = 2e-13
Identities = 72/271 (26%), Positives = 104/271 (38%), Gaps = 28/271 (10%)
Query: 107 EGTEDDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTI 166
E ED+ C C + F CQ + CI + +
Sbjct: 2722 EHGEDETHCNKFCSEAQFECQ-NHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFS 2780
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIAL 226
C T+VC+ WLCDGD DC D +DE + L N++ + + + I
Sbjct: 2781 CPGTHVCVPERWLCDGDKDCADGADE---SIAAGCLY----NSTCDDREFMCQNRQCI-- 2831
Query: 227 TKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCV-PKDFQCDGD 285
V ++ CA + D + P E RCA N +C+ + ++CDG+
Sbjct: 2832 -PKHFVCDHDRDCADGS-DESPECEYPTCGPSE-FRCA-------NGRCLSSRQWECDGE 2881
Query: 286 NDCGDWTDE----DSCPMVPGSCNA-GEFKCNDGKCIPERWRCDNERDCADGGDELNCKP 340
NDC D +DE C CNA +F C+ G+C+ E C+ + DC D DE C
Sbjct: 2882 NDCHDQSDEAPKNPHCTSPEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHI 2941
Query: 341 NSI--RNCSLDEYTCADRRCVLKTWLCDGVR 369
N R S C D + K G R
Sbjct: 2942 NECLSRKLSGCSQDCEDLKIGFKCRCRPGFR 2972
Score = 74.9 bits (176), Expect = 2e-12
Identities = 75/267 (28%), Positives = 108/267 (40%), Gaps = 34/267 (12%)
Query: 102 DGPLNEGTEDDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEH 161
D + +++++ PC + FSC + CI + CD
Sbjct: 3558 DNDCGDNSDEESCTPRPCSESEFSCA-NGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMD 3616
Query: 162 ENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDV-VKTSLLVPSANASLNIGDVITNP 220
+ + C S + CI L W CD D DC D SDE C V+T L + N
Sbjct: 3617 QFQ--CKSGH-CIPLRWRCDADADCMDGSDEEACGTGVRTCPL----------DEFQCNN 3663
Query: 221 TVLIALTKPTV-VIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTK-CVPK 278
T L KP E C + +N P RC KN + C+
Sbjct: 3664 T----LCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRC-------KNDRVCLWI 3712
Query: 279 DFQCDGDNDCGDWTDEDSC-PMVPGS--C-NAGEFKCNDGKCIPERWRCDNERDCADGGD 334
QCDG ++CGD TDE+ C P + C + EF C + +C+ RC+ DC DG D
Sbjct: 3713 GRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSD 3772
Query: 335 ELNCKPN-SIRNCSLDEYTCADR-RCV 359
E +C + + +C+ + C D RCV
Sbjct: 3773 EEDCSIDPKLTSCATNASICGDEARCV 3799
Score = 70.1 bits (164), Expect = 7e-11
Identities = 72/284 (25%), Positives = 122/284 (42%), Gaps = 24/284 (8%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRD-IDECMYEQDPVC-------SQTCSNTV 490
C++LC+ G ACAC G +LAED SCR+ +Y + + + + V
Sbjct: 2166 CQQLCLYRGRGQRACACAHG-MLAEDGASCREYAGYLLYSERTILKSIHLSDERNLNAPV 2224
Query: 491 GSFR-CGCMTGYI-LRPDERSCKPTGESPTLLFSN-RIG-IRQVWLTGDNYMSVVKGLHN 546
F M I L D R+ G + FS+ G I+Q+ G +++V+ + +
Sbjct: 2225 QPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIVENVGS 2284
Query: 547 AVALDYHYEKKLVFWSENNLRVI---RVAQMNT---KNMSDVIRWGLETPAGVAVDWIHD 600
L YH ++W+ I V Q + + + G + P +D +
Sbjct: 2285 VEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQN 2344
Query: 601 LLFWTDSGTRRVEV--ATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIER 658
L+FWT+ + + A L G+ L+ D+ P +A+ ++++D KIER
Sbjct: 2345 LMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSD-ATLDKIER 2403
Query: 659 ADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERA 702
+ DG R ++ E P GL + Y E I+W D ++RA
Sbjct: 2404 CEYDGSHRYVILKSEPVHPFGLAV-YGE-HIFWTDWVRRAVQRA 2445
Score = 64.1 bits (149), Expect = 4e-09
Identities = 73/260 (28%), Positives = 113/260 (43%), Gaps = 25/260 (9%)
Query: 1315 ERVLENACGTDNGGCSHLCLRSP-LGYTCACPTGMPF-EKSTTDQTPKKCKSHPEEFLIF 1372
E L + C +NGGCSH C +P G C+CP GM + T Q C H L
Sbjct: 1178 EGELCDQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKH----LKC 1233
Query: 1373 ATRGSITYISLESP--EQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTN 1430
+ + S++ E W V P E ++ D F + + IR I++
Sbjct: 1234 SQKCDQNKFSVKCSCYEGW-VLEPDGESCRSL------DPFKPFIIFSNRHEIRRIDLHK 1286
Query: 1431 MSESKTIISQKLETPNGLGVDWIANNIYWTD-NEHKVIEVARLDG---SSRKVLIT-GLT 1485
S ++ L L + +YWTD E K+ LD +S +V+I GL
Sbjct: 1287 GDYS--VLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLA 1344
Query: 1486 EPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYW 1545
P LA+ G +YW + IE + LDG+ R ++ D+ P + +D ++ L+W
Sbjct: 1345 TPEGLAVDWIAGNIYWVE-SNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFW 1403
Query: 1546 T--DALKDRIDTSDLNGQHR 1563
T DA RI+ + ++G R
Sbjct: 1404 TDWDASLPRIEAASMSGAGR 1423
Score = 60.9 bits (141), Expect = 4e-08
Identities = 61/229 (26%), Positives = 95/229 (41%), Gaps = 16/229 (6%)
Query: 680 LTIDYTESKIYWADA--KHHVIERAAFDGRDRRKVTTKGLPHPFALTL--FDDAIYWTDW 735
L DY E IYW D + +I R +G + + + GL +P L + +YW D
Sbjct: 3062 LDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDK 3121
Query: 736 HTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESKKP 795
+I N V +GL P R+ + LY D L +
Sbjct: 3122 GRDTIEVSKLNGAYRTVLVSSGLREP-----RALVVDVQNGYLYWT--DWGDHSLIGRIG 3174
Query: 796 IDSLDMVIPVET-IKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWP 854
+D + V+T I L D + I+W D +D I A L+GS++ ++ ++ P
Sbjct: 3175 MDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDI--P 3232
Query: 855 AGLAFDWITDKIYWTDGGTNRI-EVSKSDGSMRTLLAWDHIDKPRDIVV 902
A D +YWTD T I K+ G+ +TLL + +P D+ V
Sbjct: 3233 HIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLI-STLHRPMDLHV 3280
Score = 59.3 bits (137), Expect = 1e-07
Identities = 29/97 (29%), Positives = 43/97 (44%), Gaps = 7/97 (7%)
Query: 343 IRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAF 402
+ NC+ ++ C + +C+ W CD DC + DE C E + CRP + S
Sbjct: 3331 VSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDE---PPDCPE--FKCRPGQFQCSTGI 3385
Query: 403 RNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKC 439
C N +CDG DC DE C + ++ KC
Sbjct: 3386 --CTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKC 3420
Score = 56.4 bits (130), Expect = 9e-07
Identities = 27/78 (34%), Positives = 39/78 (50%), Gaps = 5/78 (6%)
Query: 263 CAEIDFECKNT-KCVPKDFQCDGDNDCGDWTDE--DSCPMVPGS-CNAGEFKC-NDGKCI 317
C+ F C++ C+ K ++CDG+ DC D +DE + CP C E C C+
Sbjct: 27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCV 86
Query: 318 PERWRCDNERDCADGGDE 335
P C+ +DC DG DE
Sbjct: 87 PMSRLCNGVQDCMDGSDE 104
Score = 51.6 bits (118), Expect = 2e-05
Identities = 19/33 (57%), Positives = 24/33 (72%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCDVVK 199
C T++C A W+CDG NDCGD+SDE +C VK
Sbjct: 2660 CERTSLCYAPSWVCDGANDCGDYSDERDCPGVK 2692
Score = 49.6 bits (113), Expect = 1e-04
Identities = 44/157 (28%), Positives = 64/157 (40%), Gaps = 16/157 (10%)
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGG---DELNCKPNSIRNCSLD 349
D +SC + P N G C D + + + C G D+L C+ + + D
Sbjct: 2473 DTNSCELSPCRINNGG--CQDLCLLTHQGHVNCS--CRGGRILQDDLTCRAVNSSCRAQD 2528
Query: 350 EYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRK 409
E+ CA+ C+ + CDGV C + DE + C+ SN CV+
Sbjct: 2529 EFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRR----CKKTFRQCSNG--RCVSNM 2582
Query: 410 HVCDGMKDCPRGDDEERCPLKRKCSAEE-KC-EKLCI 444
C+G DC G DE C K C E +C + CI
Sbjct: 2583 LWCNGADDCGDGSDEIPCN-KTACGVGEFRCRDGTCI 2618
Score = 44.8 bits (101), Expect = 0.003
Identities = 33/94 (35%), Positives = 38/94 (40%), Gaps = 9/94 (9%)
Query: 107 EGTEDDAGC-ITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDE---HE 162
+ D+A C I CL F C + CIP R R C E
Sbjct: 3400 QDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDE----RDCPEVTCAP 3455
Query: 163 NRTICHSTNVCIALEWLCDGDNDCGDFSDE-INC 195
N+ C T CI W+CD DNDC D SDE NC
Sbjct: 3456 NQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANC 3489
Score = 42.3 bits (95), Expect = 0.015
Identities = 27/86 (31%), Positives = 33/86 (38%), Gaps = 5/86 (5%)
Query: 110 EDDAGCI-TPCLKINFSCQISCTCIPMEK--RXXXXXXXXXXXXXXXXXRSCDEHENRTI 166
ED+ C C F C I+ CIP +C E R
Sbjct: 3443 EDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFR-- 3500
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDE 192
C + CI W CDG++DCGD SDE
Sbjct: 3501 CKDSGRCIPARWKCDGEDDCGDGSDE 3526
Score = 38.3 bits (85), Expect = 0.25
Identities = 18/58 (31%), Positives = 28/58 (48%), Gaps = 1/58 (1%)
Query: 422 DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQD 479
+D C L C+ LC+ T+ GH C+C G +L +D +CR ++ QD
Sbjct: 2472 NDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRIL-QDDLTCRAVNSSCRAQD 2528
Score = 36.3 bits (80), Expect = 1.00
Identities = 14/20 (70%), Positives = 14/20 (70%)
Query: 173 CIALEWLCDGDNDCGDFSDE 192
CI W CDGDNDC D SDE
Sbjct: 866 CIQERWKCDGDNDCLDNSDE 885
Score = 35.5 bits (78), Expect = 1.7
Identities = 13/26 (50%), Positives = 15/26 (57%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDE 192
C CI+ W CDG+ DC D SDE
Sbjct: 34 CRDQITCISKGWRCDGERDCPDGSDE 59
Score = 33.1 bits (72), Expect = 9.3
Identities = 38/152 (25%), Positives = 61/152 (40%), Gaps = 23/152 (15%)
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCT-NGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRN 404
C ++ C D C+L G +C+ G + +++C +CR Q+ A
Sbjct: 2482 CRINNGGCQDL-CLLTH---QGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFEC-ANGE 2536
Query: 405 CVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAED 464
C+N CDG+ C DE+ C++ +C+K +G C L
Sbjct: 2537 CINFSLTCDGVPHCKDKSDEK----PSYCNSR-RCKKTFRQCSNGR----CVSNMLW--- 2584
Query: 465 KYSCRDIDECMYEQDPV-CSQTCSNTVGSFRC 495
C D+C D + C++T VG FRC
Sbjct: 2585 ---CNGADDCGDGSDEIPCNKTACG-VGEFRC 2612
>AF176832-1|AAF70379.1| 4599|Homo sapiens low density lipoprotein
receptor related protein-deleted in tumor protein.
Length = 4599
Score = 524 bits (1292), Expect = e-147
Identities = 355/1173 (30%), Positives = 575/1173 (49%), Gaps = 102/1173 (8%)
Query: 559 VFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTD--SGTRRVEVAT 616
++W ++NL I VA+++ + +I +E P +A+D + +LFWTD + R+E A+
Sbjct: 1349 IYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESAS 1408
Query: 617 LDGSKRAVLVANDLDK---PRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDE 673
+ G+ R + D+ P + V + + WTD + I A DG +I
Sbjct: 1409 MSGAGRKTIY-KDMKTGAWPNGLTVDHFEKRIVWTD-ARSDAIYSALYDGTNMIEIIRGH 1466
Query: 674 IFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDD----- 728
+ + + S++YW D + + + +A V K PF L ++
Sbjct: 1467 EYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQ 1526
Query: 729 -----AIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRK 783
A + +N N H + + ++C E +K LLYARR
Sbjct: 1527 APNPCAANDGKGPCSHMCLINHNRSAACACPHL---MKLSSDKKTCYEM-KKFLLYARRS 1582
Query: 784 DLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQ 843
++R +++ P + V I +D+D ++WTD++ TI RA++NG+
Sbjct: 1583 EIRGVDIDN--PYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGTGL 1640
Query: 844 TTIVDSNLIWPAGLAFDWITDKIYW--TDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIV 901
T++ ++ GLA DW++ +YW ++ +I V++ DGS++T + IDKP+ +
Sbjct: 1641 ETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSIIHG-IDKPQCLA 1699
Query: 902 VNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNK 961
+P G +YW+D I A+MDG N K++F P GL++D V N++YW GN
Sbjct: 1700 AHPVRGKLYWTDGNT---INMANMDGSN-SKILFQNQKEPVGLSIDYVENKLYWISSGNG 1755
Query: 962 TIEYANLDGTGRTKLIENLPHPF----GLDLYGDEVFWTDWDTQSIQAANKDTGA----- 1012
TI NLDG G ++IE++ L + +++W D + + +K G
Sbjct: 1756 TINRCNLDG-GNLEVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTIL 1814
Query: 1013 KRRTLG-----------------CGKNNGGCSHLCL-LKPGGRSCACPIGIKLNKDGKTC 1054
+ +T G C NNGGCS LCL R+C C +G L K+ +C
Sbjct: 1815 RNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSC 1874
Query: 1055 ADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRK 1114
G ++L+++ IR I L+ +D ++P+ A+G+D IYWTD G K
Sbjct: 1875 -QGIESFLMYSVHEGIRGIPLEPSDKMDALMPISGTSFAVGIDFHAENDTIYWTDMGFNK 1933
Query: 1115 IQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWT 1174
I RA R T E +I NGL +GI +D IYWTD G N IEVA L+G R V++
Sbjct: 1934 ISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQ 1993
Query: 1175 GLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGR 1234
GLD PR+IA+H E G +FW++WG I +A +DG+ + V+V I WPNG++ID E +
Sbjct: 1994 GLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENK 2053
Query: 1235 LYWNDAKILTIESSDFD-GHDRRTVL--SNVPYPYGIVIVGQHIYWTD--WKTKALHRAD 1289
LYW DA+ IE D + G +R VL SNV + + + G +IYW+D ++ R
Sbjct: 2054 LYWCDARTDKIERIDLETGGNREMVLSGSNVDM-FSVAVFGAYIYWSDRAHANGSVRRGH 2112
Query: 1290 KTNASDPIVIRKNL-EGLMDIRAIQSERVL-ENACGTDNGGCSHLCL-RSPLGYTCACPT 1346
K +A++ I +R L L +++ R N C DNGGC LCL R TCAC
Sbjct: 2113 KNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLYRGNSRRTCACAH 2172
Query: 1347 GMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKN------ 1400
G E T C H E +L+++ R + I L ++ ++ P++ +N
Sbjct: 2173 GYLAEDGVT------CLRH-EGYLLYSGRTILKSIHLS--DETNLNSPIRPYENPRYFKN 2223
Query: 1401 --TIAVDYHWDLK---MIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIAN 1455
+A DY+ K IFY+D I+ I + E + +I + + + GL +
Sbjct: 2224 VIALAFDYNQRRKGTNRIFYSDAHFGNIQLIK--DNWEDRQVIVENVGSVEGLAYHRAWD 2281
Query: 1456 NIYWTDN-----EHKVIEVARLDGSSRKVLITGLTE--PRALALFPAKGYLYWSDWGE-H 1507
+YWT + ++ R R+ +IT + P LAL + ++W++W E H
Sbjct: 2282 TLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQH 2341
Query: 1508 PYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQLV 1567
P I RS L G Q++V D+ PNGLTIDY+ +LY++D +I+ + +G R +V
Sbjct: 2342 PSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVIV 2401
Query: 1568 PDAKNPF-GMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNL-EMAMEIKAVSADRQ 1625
F + + +YI+W+DW +++I+R++K TG + ++R+++ M I AV+ D
Sbjct: 2402 KSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQPMGIIAVANDTN 2461
Query: 1626 H-GWNPCKESNGGCSHLCLFRGHEYI-CACPDD 1656
+PC NGGC LCL + + C+C D
Sbjct: 2462 SCELSPCALLNGGCHDLCLLTPNGRVNCSCRGD 2494
Score = 417 bits (1026), Expect = e-115
Identities = 256/779 (32%), Positives = 387/779 (49%), Gaps = 49/779 (6%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDED--SCPMV----PGSCNAGEFKCN-DGK 315
C + F C + +C+P + CDGDNDCGD++DE +C P CN EF+C+ DG
Sbjct: 1006 CFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGN 1065
Query: 316 CIPERWRCDNERDCADGGDELNCKPNSIRNCS-LDEYTC-ADRRCVLKTWLCDGVRDCTN 373
C+P+ WRCD E+DC DG DE C +IR C +++C + RC+ K W+CDG DC +
Sbjct: 1066 CVPDLWRCDGEKDCEDGSDEKGCN-GTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCED 1124
Query: 374 GEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKC 433
DE +C D + C P +H +N C+ + +C+G KDCP G DE L +C
Sbjct: 1125 QSDEDDC------DSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGY--LCDEC 1176
Query: 434 SAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGS 492
S C C C+CP G L +D +C +D C CSQ C +
Sbjct: 1177 SLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLK--CSQVCEQHKHT 1234
Query: 493 FRCGCMTGYILRPDERSCKPTGESPT-LLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALD 551
+C C G+ L D SC ++FS R IR++ L +Y +V GL N +ALD
Sbjct: 1235 VKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALD 1294
Query: 552 YHYEKKLVFWSEN-NLRVIRVAQMNTKNMSD---VIRWGLETPAGVAVDWIHDLLFWTDS 607
+H+ + L++W++ R+ R + +S V+ GL TP G+ VDWI ++W DS
Sbjct: 1295 FHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDS 1354
Query: 608 GTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPN-PKIERADMDGDKR 666
++EVA LDGS R L+A ++ PRAIA+ P ++FWTDW N P+IE A M G R
Sbjct: 1355 NLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGR 1414
Query: 667 KTVIYD--EIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTT--KGLPHPFA 722
KT+ D WPNGLT+D+ E +I W DA+ I A +DG + ++ + L HPFA
Sbjct: 1415 KTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFA 1474
Query: 723 LTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDI---HSRSCEETPEKLLLY 779
++L+ +YWTDW T ++S NK TG + + P D+ H + P
Sbjct: 1475 VSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAAN 1534
Query: 780 ARRKDLRLKQLESKKPIDSLDMVIP-VETIKSAVALDWDQKSNSIF--WTDVEKDTINRA 836
+ L + S P + + S ++ K ++ +++ I+
Sbjct: 1535 DGKGPCSHMCLINHN--RSAACACPHLMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNP 1592
Query: 837 YLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGS-MRTLLAWDHID 895
Y N T+ D + + + FD +++YWTD T I+ + +G+ + T+++ D I
Sbjct: 1593 YFNFITAFTVPDIDDV--TVIDFDASEERLYWTDIKTQTIKRAFINGTGLETVISRD-IQ 1649
Query: 896 KPRDIVVNPEGGVMYW-SDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIY 954
R + V+ +YW S I A +DG + +I G + P LA V ++Y
Sbjct: 1650 SIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSIIHG-IDKPQCLAAHPVRGKLY 1708
Query: 955 WTDGGNKTIEYANLDGTGRTKLIENLPHPFGL--DLYGDEVFWTDWDTQSIQAANKDTG 1011
WTDG TI AN+DG+ L +N P GL D ++++W +I N D G
Sbjct: 1709 WTDG--NTINMANMDGSNSKILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGG 1765
Score = 345 bits (849), Expect = 7e-94
Identities = 209/646 (32%), Positives = 337/646 (52%), Gaps = 39/646 (6%)
Query: 1022 NNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD-GPIN-YLIFAHRVDIRVISLDVPY 1079
N+ CS +C C+C G KL+ DG++C P ++IF+ R +IR I L +
Sbjct: 1220 NHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDL---H 1276
Query: 1080 LIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRA--TRLG--THVETVIGNGLHT 1135
D L +P L+N + +D + L+YWTD + +I R + G + +E V+ +GL T
Sbjct: 1277 KRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLAT 1336
Query: 1136 ADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSD 1195
+G+ +D IYW D + IEVA+LDG R L+ ++ PRAIAL YG +FW+D
Sbjct: 1337 PEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTD 1396
Query: 1196 WGTS-AKIERADMDGNNRRVIV-DNKI-KWPNGLAIDRIEGRLYWNDAKILTIESSDFDG 1252
W + +IE A M G R+ I D K WPNGL +D E R+ W DA+ I S+ +DG
Sbjct: 1397 WDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDG 1456
Query: 1253 HDRRTVLSNVPY---PYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDI 1309
+ ++ Y P+ + + G +YWTDW+T L +A+K + VI+K D+
Sbjct: 1457 TNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDL 1516
Query: 1310 RAIQSERVLE--NACGTDN--GGCSHLCL-RSPLGYTCACPTGMPFEKSTTDQTPKKCKS 1364
+ R + N C ++ G CSH+CL CACP M K ++D KK
Sbjct: 1517 QIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACPHLM---KLSSD---KKTCY 1570
Query: 1365 HPEEFLIFATRGSITYISLESPE-QWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVI 1423
++FL++A R I + +++P + V ++ + +D+ + +++TD+ I
Sbjct: 1571 EMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTI 1630
Query: 1424 RSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNE--HKVIEVARLDGSSRKVLI 1481
+ N + +T+IS+ +++ GL VDW++ N+YW +E I VARLDGS + +I
Sbjct: 1631 KRA-FINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSII 1689
Query: 1482 TGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKER 1541
G+ +P+ LA P +G LYW+D I + +DGS +I+ Q + P GL+IDY E
Sbjct: 1690 HGIDKPQCLAAHPVRGKLYWTDGNT---INMANMDGSNSKILFQ-NQKEPVGLSIDYVEN 1745
Query: 1542 RLYWTDALKDRIDTSDLNGQHRVQLVPDAKNPF----GMTQFKDYIYWTDWYKKSIIRAD 1597
+LYW + I+ +L+G + ++++ K +T ++W D +
Sbjct: 1746 KLYWISSGNGTINRCNLDGGN-LEVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCS 1804
Query: 1598 KRTGKNITLIRTNLEMAMEIKAVSADRQHGWNPCKESNGGCSHLCL 1643
KR G+N T++R + +K + Q G N C+ +NGGCS LCL
Sbjct: 1805 KRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLCL 1850
Score = 328 bits (807), Expect = 8e-89
Identities = 178/496 (35%), Positives = 265/496 (53%), Gaps = 21/496 (4%)
Query: 263 CAEIDFECKNTK-CVPKDFQCDGDNDCGDWTDE-DSCPMVPGS-CNAGEFKCNDGKCIPE 319
CA F C+ ++ CVP+ + CDG+ DC D +DE + P + C+ F C++ CIP+
Sbjct: 2761 CAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPK 2820
Query: 320 RWRCDNERDCADGGDEL-NCKPNSIRNCSLDEYTCADRRCVLKT-WLCDGVRDCTNGEDE 377
++ CD++ DC DG DE C R C +E++CAD RC+L T W CDG DC + DE
Sbjct: 2821 QFVCDHDDDCGDGSDESPQC---GYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDE 2877
Query: 378 MNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE 437
C+ + +C + N C+ +CD DC G DE C + S +
Sbjct: 2878 APLNPKCKSAEQSCNSSFFMCKNG--RCIPSGGLCDNKDDCGDGSDERNCHINECLSKKV 2935
Query: 438 K-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCG 496
C + C + C C GF L +D +C DIDEC CSQ C NT G+++C
Sbjct: 2936 SGCSQDCQDLPVSYK-CKCWPGFQLKDDGKTCVDIDEC--SSGFPCSQQCINTYGTYKCL 2992
Query: 497 CMTGYILRPDE-RSCKP-TGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHY 554
C GY ++PD CK + E P L+ ++ IR++ G NY + +GL+N +A+D+ Y
Sbjct: 2993 CTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDY 3052
Query: 555 EKKLVFWSENNL-RVIRVAQMNTKNMSDV-IRWGLETPAGVAVDWIHDLLFWTDSGTRRV 612
++ ++W +++ R+ +M N SD+ + P +AVDWI L+W+D+ R +
Sbjct: 3053 REEFIYWIDSSRPNGSRINRM-CLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRII 3111
Query: 613 EVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYD 672
EV+ L+G +LV+ L PR +++ P ++W D P I R MDG + VI
Sbjct: 3112 EVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIET 3171
Query: 673 EIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYW 732
+I P LTIDY ++YWAD H IE + DG R KV + +P ALTLF+D IYW
Sbjct: 3172 KISRPMALTIDYVNRRLYWADENH--IEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYW 3229
Query: 733 TDWHTKSISTVNKNTG 748
TD TKS+S +K +G
Sbjct: 3230 TDGKTKSLSRAHKTSG 3245
Score = 304 bits (747), Expect = 2e-81
Identities = 206/668 (30%), Positives = 330/668 (49%), Gaps = 42/668 (6%)
Query: 1024 GGCSHLCLLKPGGRSCACPIGIKLNKDGKTC------ADGPINYLIFAHRVDIRVISLDV 1077
G CS C G +C+C G + D ++C D P L+ A+ I V L+
Sbjct: 163 GTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRP-PILLIANFETIEVFYLNG 221
Query: 1078 PYLIDVVLPLPPLKNALGVDVDHSTGLIYWTDT----GQRKIQRATRLG--THVETV-IG 1130
+ L +D ++ +I W ++ Q K + T+ G T T+ I
Sbjct: 222 SKM--ATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINIL 279
Query: 1131 NGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGY 1190
H + ID R +Y+ D + I V +G L+ L +P+AIA+ G
Sbjct: 280 QSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGK 339
Query: 1191 MFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDF 1250
+F++D+G AK+ER DMDG NR I+D+K + P LA+D + +YW D + + D+
Sbjct: 340 LFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDY 399
Query: 1251 DGHDRRTVLS--NVPYPYGIVIVGQHIYWTDWKTKALHRADKTNASD--PIVIRKNLEGL 1306
G +R TV+ V + YGI + ++Y T+ + R ++ N +D ++ +N G+
Sbjct: 400 QGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIKIENAWGI 459
Query: 1307 MDIRAIQSERVLENACGTD----NGGCSHLCLRSP--LGYTCACPTGMPFEKSTTDQTPK 1360
+ V +AC D GGCSH+CL S TC C TG F + ++ K
Sbjct: 460 RIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTG--FNLGSDGRSCK 517
Query: 1361 KCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDL 1420
+ K+ F G + + L + + +P++ + N A+D+H + I++ D
Sbjct: 518 RPKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTS 577
Query: 1421 NVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEH-KVIEVARLD--GSSR 1477
+I + +E +TI+ L+ G+ VDWI NN+YWT++ H K I VARL+ SR
Sbjct: 578 FLIGRQKIDG-TERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSR 636
Query: 1478 KVLITG-LTEPRALALFPAKGYLYWSDWGEHPY------IERSYLDGSQRQIIVQVDLGF 1530
K L+ G ++ PR + + P G++YW+DW E IE++++DG RQI V + +
Sbjct: 637 KTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLW 696
Query: 1531 PNGLTIDYKERRLYWTDALKDRIDTSDLNGQHR--VQLVPDAKNPFGMTQFKDYIYWTDW 1588
PNGLT+D+ LYW DA D I+ LNG HR V + +PFG++ +Y++WTD+
Sbjct: 697 PNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTDY 756
Query: 1589 YKKSIIRADKRTGKNITLIRTNLEMAMEIKAVSADRQHGWNPCKESNGGCSHLCLFRGHE 1648
SI + D T + +TL+R ++ +Q G N C+ +NGGCS LCL
Sbjct: 757 MNGSIFQLDLITSE-VTLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGG 815
Query: 1649 YICACPDD 1656
+CAC D+
Sbjct: 816 RVCACADN 823
Score = 258 bits (632), Expect = 1e-67
Identities = 230/825 (27%), Positives = 372/825 (45%), Gaps = 89/825 (10%)
Query: 304 CNAGEFKCNDG-KCIPERWRCDNERDCADGGDE-LNCKPNSIR-NCSLDEYTC-ADRRCV 359
C+ GEF C+D C+ + W CD + DC D DE L+ P + C L+ C +CV
Sbjct: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91
Query: 360 LKTWLCDGVRDCTNGEDE-MNC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKD 417
+ LC+GV DC +G DE ++C E+ Q C+ + ++ N+ R C + DG +
Sbjct: 92 HLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTR-C----YCEDGFEI 146
Query: 418 CPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYE 477
+D C + +C+ C + C T+ G C+C G+L+ D SC+ E +
Sbjct: 147 T---EDGRSCKDQDECAVYGTCSQTCRNTH-GSYTCSCVEGYLMQPDNRSCKAKIEPT-D 201
Query: 478 QDPVCSQTCSNTVGSF--------RCGCMTG-------YILRPDERSCKPTGESPTLLFS 522
+ P+ T+ F + G +I D + ES L
Sbjct: 202 RPPILLIANFETIEVFYLNGSKMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKC 261
Query: 523 NRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDV 582
+I + LT + +++++ HN + + + +++ ++ I V N +
Sbjct: 262 IQI-TKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTL 320
Query: 583 IRWGLETPAGVAVDWIHDLLFWTDSGT-RRVEVATLDGSKRAVLVANDLDKPRAIAVHPG 641
I L P +AVD I LF+TD G +VE +DG R ++ + ++P A+A+
Sbjct: 321 IDLELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLV 380
Query: 642 DALVFWTDWGPNPKIERADMDGDKRKTVIYD-EIFWPNGLTIDYTESKIYWADAKHHVIE 700
+ LV+W D + + D G R TVI ++ G+T+ E +Y ++ ++ I
Sbjct: 381 NKLVYWVDLYLD-YVGVVDYQGKNRHTVIQGRQVRHLYGITV--FEDYLYATNSDNYNIV 437
Query: 701 RA-AFDGRDRRKVTTKGLPHPFALTLFDDAIYWT-DWHTKSISTVNKNTGMG-------- 750
R F+G D + + + + + ++ T H + G
Sbjct: 438 RINRFNGTDIHSLIK--IENAWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSS 495
Query: 751 --IQTVHAGLNVPMDIHSRSCEETPEKLLL-YARRKDLRLKQLESKKPIDSLDMVIPVET 807
+T + RSC+ +L L Y + + ++ ++ I + +IP+E
Sbjct: 496 YKTRTCRCRTGFNLGSDGRSCKRPKNELFLFYGKGRPGIVRGMDLNTKIAD-EYMIPIEN 554
Query: 808 IKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIY 867
+ + ALD+ ++N I++ D I R ++G+ + TI+ +L G+A DWI + +Y
Sbjct: 555 LVNPRALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLY 614
Query: 868 WTDGG----TNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPC---- 919
WT+ G N + K+ S +TLL + + PR IVV+P G MYW+DW
Sbjct: 615 WTNDGHRKTINVARLEKASQSRKTLLEGE-MSHPRGIVVDPVNGWMYWTDWEEDEIDDSV 673
Query: 920 --IERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLI 977
IE+A MDG NR+ + +M WPNGL LD N +YW D IE L+GT R K++
Sbjct: 674 GRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHR-KIV 732
Query: 978 ---ENLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGA------------------KRRT 1016
L HPFGL +G+ VFWTD+ SI + T R+
Sbjct: 733 YSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDLITSEVTLLRHERPPLFGLQIYDPRKQ 792
Query: 1017 LG---CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGP 1058
G C NNGGCS LCL PGGR CAC L+++G TC P
Sbjct: 793 QGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNP 837
Score = 252 bits (618), Expect = 6e-66
Identities = 166/548 (30%), Positives = 266/548 (48%), Gaps = 47/548 (8%)
Query: 857 LAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGA 916
+A DW+T +Y+ D +RI V S+GS+ L + P+ I V+P G ++++D+G
Sbjct: 288 MAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGN 347
Query: 917 SPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKL 976
+ER DMDG NR ++I + P LALDLV+ +YW D + + G R +
Sbjct: 348 VAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGKNRHTV 407
Query: 977 IEN--LPHPFGLDLYGDEVFWTDWDTQS-----------------------IQAANKDTG 1011
I+ + H +G+ ++ D ++ T+ D + I+ K T
Sbjct: 408 IQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIKIENAWGIRIYQKRTQ 467
Query: 1012 AKRRTLGCGKNN----GGCSHLCLLKPG--GRSCACPIGIKLNKDGKTCADGPINYLIFA 1065
R+ C + GGCSH+CLL R+C C G L DG++C +F
Sbjct: 468 PTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRPKNELFLFY 527
Query: 1066 HRVD---IRVISLDVPYLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLG 1122
+ +R + L+ + ++P+ L N +D T IY+ DT I R G
Sbjct: 528 GKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDG 587
Query: 1123 THVETVIGNGLHTADGIVIDSTGRKIYWT-DGGRNSIEVAELD--GRNRKVLVWTGLDSP 1179
T ET++ + L +GI +D G +YWT DG R +I VA L+ ++RK L+ + P
Sbjct: 588 TERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHP 647
Query: 1180 RAIALHYEYGYMFWSDW------GTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEG 1233
R I + G+M+W+DW + +IE+A MDG NR++ V +K+ WPNGL +D
Sbjct: 648 RGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTN 707
Query: 1234 RLYWNDAKILTIESSDFDGHDRRTVLS--NVPYPYGIVIVGQHIYWTDWKTKALHRADKT 1291
LYW DA IE +G R+ V S + +P+G+ G +++WTD+ ++ + D
Sbjct: 708 TLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDLI 767
Query: 1292 NASDPIVIRKNLEGLMDIRAIQSERVL-ENACGTDNGGCSHLCLRSPLGYTCACPTGMPF 1350
S+ ++R L ++ + +N C +NGGCS LCL P G CAC
Sbjct: 768 -TSEVTLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLL 826
Query: 1351 EKSTTDQT 1358
+++ T T
Sbjct: 827 DENGTTCT 834
Score = 214 bits (522), Expect = 3e-54
Identities = 142/504 (28%), Positives = 222/504 (44%), Gaps = 41/504 (8%)
Query: 263 CAEIDFECKN-TKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
C E F CKN C+P + CDG +DC D +DE++C C A EF CN+ C W
Sbjct: 3632 CKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHFW 3691
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRR-CVLKTWLCDGVRDCTNGEDEMNC 380
CD E DC D DE S + C + R C+ +C+G+ +C + DE +C
Sbjct: 3692 VCDGEDDCGDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHC 3751
Query: 381 EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC---PLKRKCSAE- 436
C+ E SN + C+ CD + DC G DE+ C P + C
Sbjct: 3752 GGKLTYKARPCKKDEFACSN--KKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNV 3809
Query: 437 EKC-EKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRC 495
C + C C GF C D++EC+ CS C N GS++C
Sbjct: 3810 NPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFG--TCSHQCINVEGSYKC 3867
Query: 496 GCMTGYILRPDERSCKPTGESPTLLF----SNRIGIRQVWLTGDNYMSVVKGLHNA--VA 549
C + R +C G +L+ ++ +G + ++ + HN+
Sbjct: 3868 VCDQNFQER--NNTCIAEGSEDQVLYIANDTDILGFIYPFNYSGDHQQISHIEHNSRITG 3925
Query: 550 LDYHYEKKLVFWSEN-NLRVIRVAQMNTKNM----SDVIRWGLETPAGVAVDWIHDLLFW 604
+D +Y++ ++ WS N I +++ + S +I + P +AVDW+ ++W
Sbjct: 3926 MDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFKRPRDIAVDWVAGNIYW 3985
Query: 605 TDSGTRR---------------VEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTD 649
TD + V L+G L+ N +P AIAV+P +++WT
Sbjct: 3986 TDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTV 4045
Query: 650 WGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDR 709
G + IE A MDG R+ ++ + P GL +DY +IYWAD + +I +DG +
Sbjct: 4046 VGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDGSNS 4105
Query: 710 -RKVTTK-GLPHPFALTLFDDAIY 731
V++K GL HP + +F+D IY
Sbjct: 4106 VVSVSSKQGLLHPHRIDIFEDYIY 4129
Score = 207 bits (506), Expect = 2e-52
Identities = 164/591 (27%), Positives = 258/591 (43%), Gaps = 67/591 (11%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIAL 226
C+ST++C+ W+CDG NDCGD+SDE+ C V + S G I N
Sbjct: 2646 CNSTSLCVLPTWICDGSNDCGDYSDELKCPV-QNKHKCEENYFSCPSGRCILN------- 2697
Query: 227 TKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDN 286
T + + C + + +WNQ F C KC+ K + CDG++
Sbjct: 2698 ---TWICDGQKDCEDGRDEFHCDSSCSWNQ-----------FACSAQKCISKHWICDGED 2743
Query: 287 DCGDWTDEDSCPMVPGSCNAGEFKCNDGK-CIPERWRCDNERDCADGGDELN---CKPNS 342
DCGD DE +C A F C + C+P W CD ERDC DG DEL+ C PN+
Sbjct: 2744 DCGDGLDESDSICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNN 2803
Query: 343 IRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAF 402
C + + C ++ C+ K ++CD DC +G DE C Q C +E ++
Sbjct: 2804 --TCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDE---SPQCGYRQ--CGTEEFSCADG- 2855
Query: 403 RNCVNRKHVCDGMKDCPRGDDEERCPLKRKC-SAEEKCEKLCITTYDGHAACACPMGFLL 461
R +N + CDG DCP D + PL KC SAE+ C +G P G L
Sbjct: 2856 RCLLNTQWQCDGDFDCP--DHSDEAPLNPKCKSAEQSCNSSFFMCKNGR---CIPSGG-L 2909
Query: 462 AEDKYSCRD--------IDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPT 513
++K C D I+EC+ ++ CSQ C + S++C C G+ L+ D ++C
Sbjct: 2910 CDNKDDCGDGSDERNCHINECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDI 2969
Query: 514 GESPTLLFSNRIGIRQV----WLTGDNYMSVVKGLHNAVALDYHYEKKLVFWSENNLRVI 569
E + ++ I L D Y + +L E L+ + +R I
Sbjct: 2970 DECSSGFPCSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLS-DEEPFLILADHHEIRKI 3028
Query: 570 RVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGT---RRVEVATLDGSKRAVLV 626
N +++ GL + D+ + ++W DS R+ L+GS + V
Sbjct: 3029 STDGSN----YTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSD--IKV 3082
Query: 627 ANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTE 686
++ P A+AV ++W+D IE + ++G ++ + +P L++D
Sbjct: 3083 VHNTAVPNALAVDWIGKNLYWSD-TEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQA 3141
Query: 687 SKIYWAD-AKHHVIERAAFDGRDRRKVTTKGLPHPFALTL--FDDAIYWTD 734
+YW D ++ I R DG ++ V + P ALT+ + +YW D
Sbjct: 3142 GYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWAD 3192
Score = 203 bits (496), Expect = 4e-51
Identities = 119/334 (35%), Positives = 177/334 (52%), Gaps = 18/334 (5%)
Query: 1329 CSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEE--FLIFATRGSITYISLESP 1386
CS C+ + Y C C G + P CKS +E FLI A I IS +
Sbjct: 2978 CSQQCINTYGTYKCLCTDGYEIQPDN----PNGCKSLSDEEPFLILADHHEIRKISTDGS 3033
Query: 1387 EQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPN 1446
+ TL + + N IA+D+ + + I++ D IN ++ S + PN
Sbjct: 3034 ---NYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAVPN 3090
Query: 1447 GLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITG-LTEPRALALFPAKGYLYWSDWG 1505
L VDWI N+YW+D E ++IEV++L+G +L++ L PR L+L P GYLYW D
Sbjct: 3091 ALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCC 3150
Query: 1506 EHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQ 1565
E+P+I R +DG+ + ++++ + P LTIDY RRLYW D ++ I+ S+++G HR
Sbjct: 3151 EYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWAD--ENHIEFSNMDGSHR-H 3207
Query: 1566 LVPDAKNP--FGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAVSAD 1623
VP+ P +T F+DYIYWTD KS+ RA K +G + + + +I+ +
Sbjct: 3208 KVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSY 3267
Query: 1624 RQHGWNP--CKESNGGCSHLCLFR-GHEYICACP 1654
RQ + C +NGGCSHLCL G + CACP
Sbjct: 3268 RQPDVSKHLCMINNGGCSHLCLLAPGKTHTCACP 3301
Score = 192 bits (468), Expect = 1e-47
Identities = 106/286 (37%), Positives = 157/286 (54%), Gaps = 9/286 (3%)
Query: 482 CSQTCSNTVGSFR-CGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSV 540
CSQ C T + R C C GY L+ + SC+ G L++S GIR + L + M
Sbjct: 1845 CSQLCLPTSETTRTCMCTVGYYLQKNRMSCQ--GIESFLMYSVHEGIRGIPLEPSDKMDA 1902
Query: 541 ---VKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDW 597
+ G AV +D+H E ++W++ I A+ + D+I GL G+AVDW
Sbjct: 1903 LMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDW 1962
Query: 598 IHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIE 657
I ++WTD G +EVA L+GS R V+++ LD+PR+IAVHP L+FWT+WG P I
Sbjct: 1963 IAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIG 2022
Query: 658 RADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFD-GRDRRKVTTKG 716
+A +DG ++ ++ I WPNG++IDY E+K+YW DA+ IER + G +R V +
Sbjct: 2023 KARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGS 2082
Query: 717 LPHPFALTLFDDAIYWTD-WHTK-SISTVNKNTGMGIQTVHAGLNV 760
F++ +F IYW+D H S+ +KN T+ GL V
Sbjct: 2083 NVDMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGV 2128
Score = 185 bits (450), Expect = 1e-45
Identities = 114/333 (34%), Positives = 172/333 (51%), Gaps = 20/333 (6%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDG----KTCADGPINYLIFAHRVDIRVISLDVPYLI 1081
CS C+ G C C G ++ D K+ +D +LI A +IR IS D
Sbjct: 2978 CSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLSDEE-PFLILADHHEIRKISTDGS--- 3033
Query: 1082 DVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRL---GTHVETVIGNGLHTADG 1138
+ L L N + +D D+ IYW D+ + R R+ G+ ++ V + A
Sbjct: 3034 NYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAVPNA-- 3091
Query: 1139 IVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGT 1198
+ +D G+ +YW+D + IEV++L+G +LV L PR ++L + GY++W D
Sbjct: 3092 LAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCE 3151
Query: 1199 SAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTV 1258
I R MDG N+ V+++ KI P L ID + RLYW D IE S+ DG R V
Sbjct: 3152 YPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADEN--HIEFSNMDGSHRHKV 3209
Query: 1259 LS-NVPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQSER- 1316
+ ++P + + +IYWTD KTK+L RA KT+ +D + + + + DI+ S R
Sbjct: 3210 PNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQ 3269
Query: 1317 --VLENACGTDNGGCSHLCLRSP-LGYTCACPT 1346
V ++ C +NGGCSHLCL +P +TCACPT
Sbjct: 3270 PDVSKHLCMINNGGCSHLCLLAPGKTHTCACPT 3302
Score = 169 bits (410), Expect = 1e-40
Identities = 100/287 (34%), Positives = 149/287 (51%), Gaps = 33/287 (11%)
Query: 797 DSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDT---INRAYLNGSHQTTIVDSNLIW 853
D + + + + + +A+D+D + I+W D + INR LNGS + N
Sbjct: 3031 DGSNYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVV--HNTAV 3088
Query: 854 PAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSD 913
P LA DWI +YW+D IEVSK +G T+L + PRD+ ++P+ G +YW D
Sbjct: 3089 PNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWID 3148
Query: 914 WGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGR 973
P I R MDG N+ +I +++ P L +D V+ R+YW D + IE++N+DG+ R
Sbjct: 3149 CCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADENH--IEFSNMDGSHR 3206
Query: 974 TKL-IENLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTL--------------- 1017
K+ +++P L L+ D ++WTD T+S+ A+K +GA R +L
Sbjct: 3207 HKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHS 3266
Query: 1018 ---------GCGKNNGGCSHLCLLKPG-GRSCACPIGIKLNKDGKTC 1054
C NNGGCSHLCLL PG +CACP L D +TC
Sbjct: 3267 YRQPDVSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTC 3313
Score = 163 bits (396), Expect = 5e-39
Identities = 83/218 (38%), Positives = 117/218 (53%), Gaps = 19/218 (8%)
Query: 263 CAEIDFECKNTK-CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
C+ F+CK TK C+ K + CD D DC D +DE +C +C EF+C + CIP+ W
Sbjct: 3436 CSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKK--TCGPHEFQCKNNNCIPDHW 3493
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCE 381
RCD++ DC+D DE NCKP + C+L ++ CA+ CV + CDG DC +G DE NCE
Sbjct: 3494 RCDSQNDCSDNSDEENCKP---QTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNCE 3550
Query: 382 VSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC-PLKRKCSAEEKCE 440
SC +DQ+ C SN C+ K CDG +DC G+DE+ C P CS+ E
Sbjct: 3551 TSCSKDQFRC-------SNG--QCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSR---E 3598
Query: 441 KLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQ 478
+C + A+ C + A+ + EC +Q
Sbjct: 3599 YICASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQ 3636
Score = 151 bits (366), Expect = 2e-35
Identities = 159/659 (24%), Positives = 283/659 (42%), Gaps = 68/659 (10%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDE----CMYEQDPVCSQTCSNTVGSFR 494
C +LC+ T + C C +G+ L +++ SC+ I+ ++E S+ + +
Sbjct: 1845 CSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMDALM 1904
Query: 495 CGCMTGYILRPDERSCKPTGESPTLLFS--NRIGIRQVWLTGDNYMSVVKGLHNAVALDY 552
T + + D + T + F+ +R Q W ++ ++ G +A+D+
Sbjct: 1905 PISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTW--KEDIITNGLGRVEGIAVDW 1962
Query: 553 HYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRR- 611
++W+++ +I VA++N +I GL+ P +AV LLFWT+ G
Sbjct: 1963 IAGN--IYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPC 2020
Query: 612 VEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMD-GDKRKTVI 670
+ A LDGS++ VLV+ + P I++ + ++W D KIER D++ G R+ V+
Sbjct: 2021 IGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCD-ARTDKIERIDLETGGNREMVL 2079
Query: 671 YDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAI 730
+ ++ + IYW+D H + G T + + L + I
Sbjct: 2080 SGSNV--DMFSVAVFGAYIYWSDRAH--ANGSVRRGHKNDATETITMRTGLGVNLKEVKI 2135
Query: 731 YWTDWHTKSISTVNKNTGMGIQTVHAG--LNVPMDIHSRSCEE-----TPEKLLLYARRK 783
+ + N G ++ G H E+ E LLY+ R
Sbjct: 2136 FNRVREKGTNVCARDNGGCKQLCLYRGNSRRTCACAHGYLAEDGVTCLRHEGYLLYSGRT 2195
Query: 784 DLRLKQLESKKPIDSLDMVIPVET---IKSAVAL--DWDQK---SNSIFWTDVEKDTINR 835
L+ L + ++S + P E K+ +AL D++Q+ +N IF++D I
Sbjct: 2196 ILKSIHLSDETNLNS--PIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNIQL 2253
Query: 836 AYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGS------MRTLL 889
N + IV+ N+ GLA+ D +YWT T+ I D + ++
Sbjct: 2254 IKDNWEDRQVIVE-NVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVI 2312
Query: 890 AWDHIDKPRDIVVNPEGGVMYWSDWGAS-PCIERADMDGGNRKKLIFGQMTWPNGLALDL 948
D P + ++ +M+W++W P I R+ + G N + ++ + PNGL +D
Sbjct: 2313 TMSEDDHPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDY 2372
Query: 949 VHNRIYWTDGGNKTIEYANLDGTGRTKLIENLPHPF-GLDLYGDEVFWTDWDTQSIQAAN 1007
++Y++DG IE DG+ R ++++ P F L +Y + +FW+DW ++I +N
Sbjct: 2373 RAEKLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSN 2432
Query: 1008 KDTGAKRRTL------------------------GCGKNNGGCSHLCLLKPGGR-SCAC 1041
K TG + L C NGGC LCLL P GR +C+C
Sbjct: 2433 KYTGGDTKILRSDIPHQPMGIIAVANDTNSCELSPCALLNGGCHDLCLLTPNGRVNCSC 2491
Score = 144 bits (348), Expect = 3e-33
Identities = 72/190 (37%), Positives = 98/190 (51%), Gaps = 8/190 (4%)
Query: 239 CAKKALDNAANPRSTWNQPVELMR-CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSC 297
CA L + T+N L C +F CKN C+ ++CDGD+DC D +DEDS
Sbjct: 820 CADNQLLDENGTTCTFNPGEALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSV 879
Query: 298 PMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRR 357
SC +FKC + +CIP+RW CD DC DE N + + R C +D+++C + R
Sbjct: 880 NCFNHSCPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESN-QTCTARTCQVDQFSCGNGR 938
Query: 358 CVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKD 417
C+ + WLCD DC + DEM SCE TC P + + R C++ K CD D
Sbjct: 939 CIPRAWLCDREDDCGDQTDEM---ASCEFP--TCEPLTQFVCKSGR-CISSKWHCDSDDD 992
Query: 418 CPRGDDEERC 427
C G DE C
Sbjct: 993 CGDGSDEVGC 1002
Score = 140 bits (340), Expect = 3e-32
Identities = 85/256 (33%), Positives = 118/256 (46%), Gaps = 31/256 (12%)
Query: 263 CAEIDFEC-KNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK-CIPER 320
C F+C KN KC+P + +C+G +DCGD DE CP SC+ F+C K CI +
Sbjct: 3396 CLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCP--ENSCSPDYFQCKTTKHCISKL 3453
Query: 321 WRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC 380
W CD + DCAD DE NC + C E+ C + C+ W CD DC++ DE NC
Sbjct: 3454 WVCDEDPDCADASDEANCDK---KTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENC 3510
Query: 381 EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE-KC 439
+ TC ++ L +N +CV+ + CDG DC G DE C + CS ++ +C
Sbjct: 3511 K------PQTCTLKDFLCANG--DCVSSRFWCDGDFDCADGSDERNC--ETSCSKDQFRC 3560
Query: 440 EK-LCITT---YDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC-SQTCSNTVGSFR 494
CI DGH C ED+ SC ++ +C S C + S +
Sbjct: 3561 SNGQCIPAKWKCDGHEDCK------YGEDEKSCEPASPTCSSREYICASDGCIS--ASLK 3612
Query: 495 CGCMTGYILRPDERSC 510
C DE C
Sbjct: 3613 CNGEYDCADGSDEMDC 3628
Score = 135 bits (327), Expect = 1e-30
Identities = 71/213 (33%), Positives = 102/213 (47%), Gaps = 24/213 (11%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C++ F C N +C+P ++CDG DC DE SC +C++ E+ C CI +
Sbjct: 3553 CSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASDGCISASLK 3612
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADR-RCVLKTWLCDGVRDCTNGEDEMNCE 381
C+ E DCADG DE++C + C D++ C ++ C+ WLCDG+ DC +G DE N
Sbjct: 3613 CNGEYDCADGSDEMDC----VTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEEN-- 3666
Query: 382 VSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEK 441
CE CR E L +N+ C VCDG DC GD+ + P + C K
Sbjct: 3667 --CERGGNICRADEFLCNNSL--CKLHFWVCDGEDDC--GDNSDEAP--------DMCVK 3712
Query: 442 LCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
+ H C + + + C IDEC
Sbjct: 3713 FLCPSTRPH---RCRNNRICLQSEQMCNGIDEC 3742
Score = 132 bits (320), Expect = 8e-30
Identities = 58/170 (34%), Positives = 87/170 (51%), Gaps = 17/170 (10%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVP-------GSCNAGEFKCNDGK 315
CA ++F C + C+P+ +C+ + DC D +DE +C G G +CN
Sbjct: 2591 CATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTS 2650
Query: 316 -CIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNG 374
C+ W CD DC D DEL C + C + ++C RC+L TW+CDG +DC +G
Sbjct: 2651 LCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDG 2710
Query: 375 EDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE 424
DE +C+ SC +Q+ C Q+ C+++ +CDG DC G DE
Sbjct: 2711 RDEFHCDSSCSWNQFACSAQK---------CISKHWICDGEDDCGDGLDE 2751
Score = 130 bits (314), Expect = 4e-29
Identities = 62/177 (35%), Positives = 88/177 (49%), Gaps = 18/177 (10%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C + F+C+N +C+PK + CDG NDCG DE + +C +F C +G+CIP W
Sbjct: 886 CPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWL 945
Query: 323 CDNERDCADGGDEL-NCKPNSIRNCS-LDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC 380
CD E DC D DE+ +C+ C L ++ C RC+ W CD DC +G DE+ C
Sbjct: 946 CDREDDCGDQTDEMASCE---FPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGC 1002
Query: 381 EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE 437
SC ++Q+ C + C+ CDG DC DE + C+ EE
Sbjct: 1003 VHSCFDNQFRC---------SSGRCIPGHWACDGDNDCGDFSDEAQI----NCTKEE 1046
Score = 126 bits (303), Expect = 1e-27
Identities = 65/181 (35%), Positives = 89/181 (49%), Gaps = 17/181 (9%)
Query: 260 LMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDE-DSCPMVPGSCNAGEFKCNDGKCIP 318
L C F CK KC+P ++CD +DCGD +DE D CP C G F+C G C
Sbjct: 3314 LSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEF--RCQPGRFQCGTGLCAL 3371
Query: 319 ERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCA-DRRCVLKTWLCDGVRDCTNGEDE 377
+ CD E DC D DELNC + C ++ C +++C+ C+G DC + EDE
Sbjct: 3372 PAFICDGENDCGDNSDELNCDTHV---CLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDE 3428
Query: 378 MNC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAE 436
+C E SC D + C+ +H C+++ VCD DC DE C K+ C
Sbjct: 3429 RDCPENSCSPDYFQCKTTKH--------CISKLWVCDEDPDCADASDEANCD-KKTCGPH 3479
Query: 437 E 437
E
Sbjct: 3480 E 3480
Score = 122 bits (293), Expect = 2e-26
Identities = 78/276 (28%), Positives = 138/276 (50%), Gaps = 16/276 (5%)
Query: 482 CSQTCS-NTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGD--NYM 538
CS C N S C C L D+++C + LL++ R IR V + N++
Sbjct: 1540 CSHMCLINHNRSAACACPHLMKLSSDKKTCYEMKKF--LLYARRSEIRGVDIDNPYFNFI 1597
Query: 539 SV--VKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVD 596
+ V + + +D+ ++ ++W++ + I+ A +N + VI +++ G+AVD
Sbjct: 1598 TAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVD 1657
Query: 597 WIHDLLFWTDS--GTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNP 654
W+ L+W S ++ VA LDGS + ++ + +DKP+ +A HP ++WTD
Sbjct: 1658 WVSRNLYWISSEFDETQINVARLDGSLKTSII-HGIDKPQCLAAHPVRGKLYWTD---GN 1713
Query: 655 KIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTT 714
I A+MDG K +++ P GL+IDY E+K+YW + + I R DG + + +
Sbjct: 1714 TINMANMDGSNSK-ILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIES 1772
Query: 715 --KGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTG 748
+ L ALT+ D ++W D + + T +K G
Sbjct: 1773 MKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDG 1808
Score = 116 bits (279), Expect = 8e-25
Identities = 59/173 (34%), Positives = 82/173 (47%), Gaps = 5/173 (2%)
Query: 267 DFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNE 326
+FEC N +C+ CDG C D +DE SC G C + +CIP CD E
Sbjct: 2515 EFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGE 2574
Query: 327 RDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC-EVSCE 385
DC D DEL+CK + C+ E+ CAD C+ ++ C+ DC + DE NC C
Sbjct: 2575 NDCGDNSDELDCK---VSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCT 2631
Query: 386 E-DQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE 437
+ + + N+ CV +CDG DC DE +CP++ K EE
Sbjct: 2632 HFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEE 2684
Score = 111 bits (268), Expect = 2e-23
Identities = 91/356 (25%), Positives = 150/356 (42%), Gaps = 36/356 (10%)
Query: 1327 GGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSIT---YISL 1383
G CSH C+ Y C C +T + ++ L A I Y
Sbjct: 3852 GTCSHQCINVEGSYKCVCDQNFQERNNTCI-----AEGSEDQVLYIANDTDILGFIYPFN 3906
Query: 1384 ESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFY-TDLDLNVI---RSINMTNMSESKTIIS 1439
S + ++ ++ +D ++ MI + T + I R + +I
Sbjct: 3907 YSGDHQQIS-HIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLIC 3965
Query: 1440 QKLETPNGLGVDWIANNIYWTDNEHK---------------VIEVARLDGSSRKVLITGL 1484
+ + P + VDW+A NIYWTD+ I V +L+G + L+T +
Sbjct: 3966 PEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNM 4025
Query: 1485 T-EPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRL 1543
EP A+A+ P +G +YW+ G+H +IE + +DG+ R+I+VQ +L P GL +DY R+
Sbjct: 4026 AGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERI 4085
Query: 1544 YWTDALKDRIDTSDLNGQHRVQLVPDAK---NPFGMTQFKDYIYWTDWYKKSIIRADKRT 1600
YW D I + +G + V V + +P + F+DYIY K + R K
Sbjct: 4086 YWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAG-PKNGVFRVQKFG 4144
Query: 1601 GKNITLIRTNLEMAMEIKAVSADRQHGW-NPCKESNGGCSHLCLFRGHEYICACPD 1655
++ + N++ + +Q NPC + C LCL C CP+
Sbjct: 4145 HGSVEYLALNIDKTKGVLISHRYKQLDLPNPCLDL--ACEFLCLLNPSGATCVCPE 4198
Score = 101 bits (243), Expect = 2e-20
Identities = 92/351 (26%), Positives = 146/351 (41%), Gaps = 30/351 (8%)
Query: 1024 GGCSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGPINYLIF-AHRVDIRVISLDVPYLI 1081
G CSH C+ G C C + + TC A+G + +++ A+ DI Y
Sbjct: 3852 GTCSHQCINVEGSYKCVCDQNFQ--ERNNTCIAEGSEDQVLYIANDTDILGFIYPFNYSG 3909
Query: 1082 D--VVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTAD-- 1137
D + + G+DV + +I W+ R+ + +GL +
Sbjct: 3910 DHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFK 3969
Query: 1138 ---GIVIDSTGRKIYWTDGGRN---------------SIEVAELDGRNRKVLVWTGLDSP 1179
I +D IYWTD R SI V +L+G N L+ P
Sbjct: 3970 RPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEP 4029
Query: 1180 RAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND 1239
AIA++ + G M+W+ G + IE A MDG RR++V ++ P GLA+D R+YW D
Sbjct: 4030 YAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWAD 4089
Query: 1240 AKILTIESSDFDGHDRRTVLSN---VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDP 1296
++ I S +DG + +S+ + +P+ I I +IY K + R K
Sbjct: 4090 FELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPK-NGVFRVQKFGHGSV 4148
Query: 1297 IVIRKNLEGLMDIRAIQSERVLENACGTDNGGCSHLCLRSPLGYTCACPTG 1347
+ N++ + + L+ + C LCL +P G TC CP G
Sbjct: 4149 EYLALNIDKTKGVLISHRYKQLDLPNPCLDLACEFLCLLNPSGATCVCPEG 4199
Score = 97.9 bits (233), Expect = 3e-19
Identities = 63/214 (29%), Positives = 88/214 (41%), Gaps = 21/214 (9%)
Query: 303 SCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKT 362
+C A +F+C KCIP W+CD DC DG DE + P C + C C L
Sbjct: 3316 NCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEF--RCQPGRFQCGTGLCALPA 3373
Query: 363 WLCDGVRDCTNGEDEMNCEVS-CEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRG 421
++CDG DC + DE+NC+ C Q+ C + C+ C+G DC
Sbjct: 3374 FICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQ--------KCIPVNLRCNGQDDCGDE 3425
Query: 422 DDEERCPLKRKCSAEE---KCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQ 478
+DE CP + CS + K K CI+ C A D+ +C D C +
Sbjct: 3426 EDERDCP-ENSCSPDYFQCKTTKHCISKL---WVCDEDPDCADASDEANC-DKKTCGPHE 3480
Query: 479 DPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP 512
+ C +RC DE +CKP
Sbjct: 3481 FQCKNNNC--IPDHWRCDSQNDCSDNSDEENCKP 3512
Score = 89.8 bits (213), Expect = 8e-17
Identities = 80/290 (27%), Positives = 137/290 (47%), Gaps = 23/290 (7%)
Query: 1019 CGKNNGGCSHLCLLKPG-GRSCACPIGIKLNKDGKTC--ADGPINYLIFAHRVDIRVISL 1075
C NNGGCS+ C + PG G C+CP G++LNKD KTC D N+L + + ++
Sbjct: 1176 CSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTV 1235
Query: 1076 DVPYLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHT 1135
L + ++ VD +I+ R+I L +++ GL
Sbjct: 1236 KCSCYEGWKLDVDG-ESCTSVD-PFEAFIIFSIRHEIRRID----LHKRDYSLLVPGLRN 1289
Query: 1136 ADGIVIDSTGRKIYWTDGGRNSI---EVAELDGRNR-KVLVWTGLDSPRAIALHYEYGYM 1191
+ +YWTD + I +++E G + +V+V GL +P + + + G +
Sbjct: 1290 TIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNI 1349
Query: 1192 FWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWN--DAKILTIESSD 1249
+W D +IE A +DG+ R ++ ++ P +A+D G L+W DA IES+
Sbjct: 1350 YWID-SNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESAS 1408
Query: 1250 FDGHDRRTVLSNV---PYPYGIVI--VGQHIYWTDWKTKALHRA--DKTN 1292
G R+T+ ++ +P G+ + + I WTD ++ A++ A D TN
Sbjct: 1409 MSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTN 1458
Score = 89.4 bits (212), Expect = 1e-16
Identities = 104/403 (25%), Positives = 155/403 (38%), Gaps = 72/403 (17%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
++C HE + C + N CI W CD NDC D SDE NC +T L A+ GD
Sbjct: 3474 KTCGPHEFQ--CKNNN-CIPDHWRCDSQNDCSDNSDEENCK-PQTCTLKDFLCAN---GD 3526
Query: 216 VITNPTVL---IALTKPTVVIRYESFCAKKAL--DNAANPRSTWN-QPVELMRCAEIDFE 269
+++ + E+ C+K N + W E + E +
Sbjct: 3527 CVSSRFWCDGDFDCADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKS 3586
Query: 270 CK--NTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDG--------KCIPE 319
C+ + C +++ C D C CN GE+ C DG +C +
Sbjct: 3587 CEPASPTCSSREYICASD----------GCISASLKCN-GEYDCADGSDEMDCVTECKED 3635
Query: 320 RWRCDNE-------------RDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCD 366
++RC N+ DC DG DE NC+ C DE+ C + C L W+CD
Sbjct: 3636 QFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGG-NICRADEFLCNNSLCKLHFWVCD 3694
Query: 367 GVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEER 426
G DC + DE C ++ C R C+ + +C+G+ +C DE+
Sbjct: 3695 GEDDCGDNSDE--APDMCV--KFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDH 3750
Query: 427 CPLK-----RKCSAEE-KC-EKLCI------TTYDGHAACACPMGFLLAEDKYSCRD-ID 472
C K R C +E C K CI D + G +A +Y+C D ++
Sbjct: 3751 CGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVN 3810
Query: 473 ECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C D C+Q + S C C G+ R C+ E
Sbjct: 3811 PC--GDDAYCNQIKT----SVFCRCKPGFQRNMKNRQCEDLNE 3847
Score = 81.0 bits (191), Expect = 4e-14
Identities = 70/241 (29%), Positives = 96/241 (39%), Gaps = 40/241 (16%)
Query: 854 PAGLAFDWITDKIYWTDGGTNR---------------IEVSKSDGSMRTLLAWDHIDKPR 898
P +A DW+ IYWTD I V + +G T L + +P
Sbjct: 3971 PRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPY 4030
Query: 899 DIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDG 958
I VNP+ G+MYW+ G IE A MDG R+ L+ + P GLA+D RIYW D
Sbjct: 4031 AIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADF 4090
Query: 959 GNKTIEYANLDGTGRTKLI---ENLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGA-KR 1014
I DG+ + + L HP +D++ D ++ + G+ +
Sbjct: 4091 ELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKNGVFRVQKFGHGSVEY 4150
Query: 1015 RTLGCGKNNG-------------------GCSHLCLLKPGGRSCACPIGIKLNKDGKTCA 1055
L K G C LCLL P G +C CP G K +G TC
Sbjct: 4151 LALNIDKTKGVLISHRYKQLDLPNPCLDLACEFLCLLNPSGATCVCPEG-KYLING-TCN 4208
Query: 1056 D 1056
D
Sbjct: 4209 D 4209
Score = 79.8 bits (188), Expect = 8e-14
Identities = 65/226 (28%), Positives = 98/226 (43%), Gaps = 24/226 (10%)
Query: 162 ENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPT 221
+N+ C S+ CI W CDGDNDCGDFSDE + K + P A N + +P
Sbjct: 1008 DNQFRC-SSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSP---AGCNGNEFQCHP- 1062
Query: 222 VLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNT-KCVPKDF 280
V +K ++ ++ + N + L + F C +T +C+ K +
Sbjct: 1063 ------DGNCVPDLWRCDGEKDCEDGSDEKGC-NGTIRLCD-HKTKFSCWSTGRCINKAW 1114
Query: 281 QCDGDNDCGDWTDEDSCPMVPGSCNAGEFKC-ND-GKCIPERWRCDNERDCADGGDELNC 338
CDGD DC D +DED C C + C ND C+ C+ ++DC DG DE
Sbjct: 1115 VCDGDIDCEDQSDEDDCDSF--LCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDE--- 1169
Query: 339 KPNSIRNCSLDEYTCADRRCVL--KTWLCDGVRDCTNGEDEMNCEV 382
CSL+ C++ V+ + +C +D CE+
Sbjct: 1170 -GYLCDECSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEI 1214
Score = 79.0 bits (186), Expect = 1e-13
Identities = 74/287 (25%), Positives = 107/287 (37%), Gaps = 36/287 (12%)
Query: 111 DDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTICHST 170
D+ C+T C + F C+ CIP+ R + +
Sbjct: 3624 DEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNN 3683
Query: 171 NVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPT 230
++C W+CDG++DCGD SDE VK L PS T P
Sbjct: 3684 SLCKLHFWVCDGEDDCGDNSDEAPDMCVK--FLCPS-----------TRPH---RCRNNR 3727
Query: 231 VVIRYESFC--AKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDC 288
+ ++ E C + DN+ + C + +F C N KC+P D QCD +DC
Sbjct: 3728 ICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDC 3787
Query: 289 GDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDEL--NCKPNSIRNC 346
GD +DE C + P E+ C D P C ++ C + CKP RN
Sbjct: 3788 GDGSDEQGCRIAP-----TEYTCED-NVNP----CGDDAYCNQIKTSVFCRCKPGFQRN- 3836
Query: 347 SLDEYTCADRRCVLKTWLCDGVRDCTN--GEDEMNCEVSCEEDQYTC 391
+ C D L C C N G + C+ + +E TC
Sbjct: 3837 -MKNRQCEDLNECLVFGTCS--HQCINVEGSYKCVCDQNFQERNNTC 3880
Score = 69.7 bits (163), Expect = 9e-11
Identities = 80/310 (25%), Positives = 129/310 (41%), Gaps = 26/310 (8%)
Query: 1301 KNLEGLMDIRAIQSERVLENACGTDNGGCSHLCLRSP-LGYTCACPTGMPFEK-STTDQT 1358
K G D E L + C +NGGCS+ C P G C+CP G+ K + T +
Sbjct: 1155 KLCNGKKDCPDGSDEGYLCDECSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEI 1214
Query: 1359 PKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDL 1418
C +H + + + E W + + + ++ +VD ++ +IF
Sbjct: 1215 VDYCSNHLKCSQVCEQHKHT--VKCSCYEGWKLDV---DGESCTSVD-PFEAFIIFSI-- 1266
Query: 1419 DLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSS-- 1476
+ IR I++ S ++ L L + + +YWTD I +L S
Sbjct: 1267 -RHEIRRIDLHKRDYS--LLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGV 1323
Query: 1477 ---RKVLITGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNG 1533
V+ GL P L + G +YW D IE + LDGS R ++ + P
Sbjct: 1324 SAIEVVVEHGLATPEGLTVDWIAGNIYWID-SNLDQIEVAKLDGSLRTTLIAGAMEHPRA 1382
Query: 1534 LTIDYKERRLYWT--DALKDRIDTSDLNGQHRVQLVPDAKN---PFGMT--QFKDYIYWT 1586
+ +D + L+WT DA RI+++ ++G R + D K P G+T F+ I WT
Sbjct: 1383 IALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWT 1442
Query: 1587 DWYKKSIIRA 1596
D +I A
Sbjct: 1443 DARSDAIYSA 1452
Score = 68.1 bits (159), Expect = 3e-10
Identities = 72/269 (26%), Positives = 114/269 (42%), Gaps = 19/269 (7%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPY- 1079
K GCS C P C C G +L DGKTC D I+ + I+ Y
Sbjct: 2933 KKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVD--IDECSSGFPCSQQCINTYGTYK 2990
Query: 1080 --LIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTAD 1137
D P N D LI +I++ + G++ T++ GL+
Sbjct: 2991 CLCTDGYEIQPDNPNGCKSLSDEEPFLIL---ADHHEIRKISTDGSNY-TLLKQGLNNVI 3046
Query: 1138 GIVIDSTGRKIYWTDGGR---NSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWS 1194
I D IYW D R + I L+G + KV+ T + P A+A+ + ++WS
Sbjct: 3047 AIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAV--PNALAVDWIGKNLYWS 3104
Query: 1195 DWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFDGH 1253
D IE + ++G ++V ++K+P L++D G LYW D + I DG
Sbjct: 3105 D-TEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGT 3163
Query: 1254 DRRTVL-SNVPYPYGIVI--VGQHIYWTD 1279
++ V+ + + P + I V + +YW D
Sbjct: 3164 NQSVVIETKISRPMALTIDYVNRRLYWAD 3192
Score = 59.3 bits (137), Expect = 1e-07
Identities = 54/217 (24%), Positives = 90/217 (41%), Gaps = 16/217 (7%)
Query: 680 LTIDYTESKIYWADAKH---HVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWH 736
+ DY E IYW D+ I R +G D + V +P+ A+ +YW+D
Sbjct: 3048 IDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTE 3107
Query: 737 TKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESKKPI 796
+ I N V L P D+ P+ LY D + +
Sbjct: 3108 KRIIEVSKLNGLYPTILVSKRLKFPRDL-----SLDPQAGYLY--WIDCCEYPHIGRVGM 3160
Query: 797 DSLDMVIPVET-IKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPA 855
D + + +ET I +AL D + ++W D ++ I + ++GSH+ + + ++ P
Sbjct: 3161 DGTNQSVVIETKISRPMALTIDYVNRRLYWAD--ENHIEFSNMDGSHRHKVPNQDI--PG 3216
Query: 856 GLAFDWITDKIYWTDGGTNRI-EVSKSDGSMRTLLAW 891
+A D IYWTDG T + K+ G+ R L +
Sbjct: 3217 VIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIY 3253
Score = 56.0 bits (129), Expect = 1e-06
Identities = 51/163 (31%), Positives = 74/163 (45%), Gaps = 21/163 (12%)
Query: 263 CAEIDFECKN-TKCVPKDFQCDGDNDCGDWTDE--DSCP-MVPGSCNAGEFKC-NDGKCI 317
C +F C + CV + + CDGD DC D +DE D+CP V C C KC+
Sbjct: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91
Query: 318 PERWRCDNERDCADGGDE-LNCKPNSIRNC-SLD-EYTCADRRCVLKTWLCDGVRDCTNG 374
C+ DC DG DE ++C+ + NC L+ +Y C R + + DG +G
Sbjct: 92 HLSQLCNGVLDCPDGYDEGVHCQ-ELLSNCQQLNCQYKCTMVRNSTRCYCEDGFEITEDG 150
Query: 375 ---EDEMNCEV--SCEE------DQYTCRPQE-HLMSNAFRNC 405
+D+ C V +C + YTC E +LM R+C
Sbjct: 151 RSCKDQDECAVYGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSC 193
Score = 50.4 bits (115), Expect = 6e-05
Identities = 22/41 (53%), Positives = 26/41 (63%), Gaps = 1/41 (2%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCD 196
R CD H+ + C ST CI W+CDGD DC D SDE +CD
Sbjct: 1093 RLCD-HKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCD 1132
Score = 50.4 bits (115), Expect = 6e-05
Identities = 37/113 (32%), Positives = 51/113 (45%), Gaps = 12/113 (10%)
Query: 88 SLQKAID---VIHTDPDDGPLNEGTEDDAGCITPCLKINFSCQISCTCIPME-----KRX 139
S QK I + + D G + ++ G IT C FSCQ S C+P +R
Sbjct: 2728 SAQKCISKHWICDGEDDCGDGLDESDSICGAIT-CAADMFSCQGSRACVPRHWLCDGERD 2786
Query: 140 XXXXXXXXXXXXXXXXRSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDE 192
+CDE N +CH+ VCI +++CD D+DCGD SDE
Sbjct: 2787 CPDGSDELSTAGCAPNNTCDE--NAFMCHN-KVCIPKQFVCDHDDDCGDGSDE 2836
Score = 50.4 bits (115), Expect = 6e-05
Identities = 31/90 (34%), Positives = 39/90 (43%), Gaps = 8/90 (8%)
Query: 111 DDAGCITP-CLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHE---NRTI 166
D+ C T CL F C + CIP+ R R C E+ +
Sbjct: 3387 DELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDE----RDCPENSCSPDYFQ 3442
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCD 196
C +T CI+ W+CD D DC D SDE NCD
Sbjct: 3443 CKTTKHCISKLWVCDEDPDCADASDEANCD 3472
Score = 48.4 bits (110), Expect = 2e-04
Identities = 48/186 (25%), Positives = 75/186 (40%), Gaps = 21/186 (11%)
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSI--RNCSLDE 350
D +SC + P C C+D + R + C+ GD + + N +N S +
Sbjct: 2459 DTNSCELSP--CALLNGGCHDLCLLTPNGRVN----CSCRGDRILLEDNRCVTKNSSCNA 2512
Query: 351 YT---CADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVN 407
Y+ C + C+ CDG+ C + DE + CE +CR N R C+
Sbjct: 2513 YSEFECGNGECIDYQLTCDGIPHCKDKSDEKL--LYCENR--SCRRGFKPCYN--RRCIP 2566
Query: 408 RKHVCDGMKDCPRGDDEERCPLKRKCSAEEKC-EKLCITTYDGHAACACPMGFLLAEDKY 466
+CDG DC DE C + + E +C + CI A C + A D+
Sbjct: 2567 HGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPR---SARCNQNIDCADASDEK 2623
Query: 467 SCRDID 472
+C + D
Sbjct: 2624 NCNNTD 2629
Score = 47.6 bits (108), Expect = 4e-04
Identities = 26/86 (30%), Positives = 36/86 (41%), Gaps = 2/86 (2%)
Query: 111 DDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTICHST 170
D+ C++ C F C+ CIP + R C T
Sbjct: 3309 DNRTCLSNCTASQFRCKTD-KCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQC-GT 3366
Query: 171 NVCIALEWLCDGDNDCGDFSDEINCD 196
+C ++CDG+NDCGD SDE+NCD
Sbjct: 3367 GLCALPAFICDGENDCGDNSDELNCD 3392
Score = 45.6 bits (103), Expect = 0.002
Identities = 33/131 (25%), Positives = 62/131 (47%), Gaps = 3/131 (2%)
Query: 825 WTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWT-DGGTNRIEVSKSDG 883
WT + + +IN LNG + T ++ + P +A + +YWT G + IE + DG
Sbjct: 4001 WTSL-RYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDG 4059
Query: 884 SMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNG 943
++R +L ++ +P + V+ +YW+D+ S I DG N + + +
Sbjct: 4060 TLRRILVQKNLQRPTGLAVDYFSERIYWADFELS-IIGSVLYDGSNSVVSVSSKQGLLHP 4118
Query: 944 LALDLVHNRIY 954
+D+ + IY
Sbjct: 4119 HRIDIFEDYIY 4129
Score = 43.6 bits (98), Expect = 0.007
Identities = 18/35 (51%), Positives = 21/35 (60%), Gaps = 2/35 (5%)
Query: 158 CDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDE 192
CD E +CH C++ WLCDGD DC D SDE
Sbjct: 32 CDPGE--FLCHDHVTCVSQSWLCDGDPDCPDDSDE 64
Score = 43.6 bits (98), Expect = 0.007
Identities = 24/73 (32%), Positives = 39/73 (53%), Gaps = 1/73 (1%)
Query: 813 ALDWDQKSNSIFWTDV-EKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDG 871
A+ + K ++WT V + I A ++G+ + +V NL P GLA D+ +++IYW D
Sbjct: 4031 AIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADF 4090
Query: 872 GTNRIEVSKSDGS 884
+ I DGS
Sbjct: 4091 ELSIIGSVLYDGS 4103
Score = 42.7 bits (96), Expect = 0.012
Identities = 16/30 (53%), Positives = 21/30 (70%), Gaps = 1/30 (3%)
Query: 166 ICHSTNVCIALEWLCDGDNDCGDFSDEINC 195
+C S CI+ +W CD D+DCGD SDE+ C
Sbjct: 974 VCKSGR-CISSKWHCDSDDDCGDGSDEVGC 1002
Score = 42.3 bits (95), Expect = 0.015
Identities = 31/102 (30%), Positives = 42/102 (41%), Gaps = 7/102 (6%)
Query: 99 DPDDGPLNEGTEDDAGCIT-PCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRS 157
D DD L+ ED C C F CQ + CIP KR ++
Sbjct: 865 DGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNN-RCIP--KRWLCDGANDCGSNEDESNQT 921
Query: 158 CDEHENRTICHS--TNVCIALEWLCDGDNDCGDFSDEI-NCD 196
C + S CI WLCD ++DCGD +DE+ +C+
Sbjct: 922 CTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCE 963
Score = 40.7 bits (91), Expect = 0.046
Identities = 16/25 (64%), Positives = 19/25 (76%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDV 197
CI LCDG+NDCGD SDE++C V
Sbjct: 2564 CIPHGKLCDGENDCGDNSDELDCKV 2588
Score = 39.5 bits (88), Expect = 0.11
Identities = 22/85 (25%), Positives = 36/85 (42%), Gaps = 1/85 (1%)
Query: 111 DDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTICHST 170
D+ C T C K F C + CIP + + + +R ++
Sbjct: 3545 DERNCETSCSKDQFRCS-NGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICAS 3603
Query: 171 NVCIALEWLCDGDNDCGDFSDEINC 195
+ CI+ C+G+ DC D SDE++C
Sbjct: 3604 DGCISASLKCNGEYDCADGSDEMDC 3628
Score = 39.1 bits (87), Expect = 0.14
Identities = 17/35 (48%), Positives = 19/35 (54%), Gaps = 1/35 (2%)
Query: 162 ENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCD 196
EN C S CI W+CDG DC D DE +CD
Sbjct: 2684 ENYFSCPSGR-CILNTWICDGQKDCEDGRDEFHCD 2717
Score = 38.7 bits (86), Expect = 0.19
Identities = 15/30 (50%), Positives = 20/30 (66%), Gaps = 1/30 (3%)
Query: 163 NRTICHSTNVCIALEWLCDGDNDCGDFSDE 192
N+ C S CI+ W+CDG++DCGD DE
Sbjct: 2723 NQFAC-SAQKCISKHWICDGEDDCGDGLDE 2751
Score = 37.1 bits (82), Expect = 0.57
Identities = 15/25 (60%), Positives = 17/25 (68%), Gaps = 2/25 (8%)
Query: 173 CIALEWLCDGDNDCGDFSDE--INC 195
CI W CDGD+DC D SDE +NC
Sbjct: 857 CIQARWKCDGDDDCLDGSDEDSVNC 881
Score = 33.1 bits (72), Expect = 9.3
Identities = 15/34 (44%), Positives = 19/34 (55%), Gaps = 1/34 (2%)
Query: 163 NRTICHSTNVCIALEWLCDGDNDCGDFSDE-INC 195
N C TN C+ L LC+G DC D DE ++C
Sbjct: 80 NHIACLGTNKCVHLSQLCNGVLDCPDGYDEGVHC 113
>AF283374-1|AAL38108.1| 1731|Homo sapiens candidate tumor suppressor
protein protein.
Length = 1731
Score = 519 bits (1281), Expect = e-146
Identities = 354/1173 (30%), Positives = 573/1173 (48%), Gaps = 102/1173 (8%)
Query: 559 VFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTD--SGTRRVEVAT 616
++W ++NL I VA+++ + +I +E P +A+D + +LFWTD + R+E A+
Sbjct: 425 IYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESAS 484
Query: 617 LDGSKRAVLVANDLDK---PRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDE 673
+ G+ R + D+ P + V + + WTD + I A DG +I
Sbjct: 485 MSGAGRKTIY-KDMKTGAWPNGLTVDHFEKRIVWTD-ARSDAIYSALYDGTNMIEIIRGH 542
Query: 674 IFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDD----- 728
+ + + S++YW D + + + +A V K PF L ++
Sbjct: 543 EYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQ 602
Query: 729 -----AIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRK 783
A + +N N H + + ++C +K LLYARR
Sbjct: 603 APNPCAANDGKGPCSHMCLINHNRSAACACPHL---MKLSSDKKTCYGM-KKFLLYARRS 658
Query: 784 DLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQ 843
++R +++ P + V I +D+D ++WTD++ TI RA++NG+
Sbjct: 659 EIRGVDIDN--PYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGTGL 716
Query: 844 TTIVDSNLIWPAGLAFDWITDKIYW--TDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIV 901
T++ ++ GLA DW++ +YW ++ +I V++ DGS++T + IDKP+ +
Sbjct: 717 ETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSIIHG-IDKPQCLA 775
Query: 902 VNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNK 961
+P G +YW+D I A+MDG N K++F P GL++D V N++YW GN
Sbjct: 776 AHPVRGKLYWTDGNT---INMANMDGSN-SKILFQNQKEPVGLSIDYVENKLYWISSGNG 831
Query: 962 TIEYANLDGTGRTKLIENLPHPF----GLDLYGDEVFWTDWDTQSIQAANKDTGA----- 1012
TI NLDG G ++IE++ L + +++W D + + +K G
Sbjct: 832 TINRCNLDG-GNLEVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTIL 890
Query: 1013 KRRTLG-----------------CGKNNGGCSHLCL-LKPGGRSCACPIGIKLNKDGKTC 1054
+ +T G C NNGGCS LCL R+C C +G L K+ +C
Sbjct: 891 RNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSC 950
Query: 1055 ADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRK 1114
G ++L+++ IR I L+ +D ++P+ A+G+D IYWTD G K
Sbjct: 951 -QGIESFLMYSVHEGIRGIPLEPSDKMDALMPISGTSFAVGIDFHAENDTIYWTDMGFNK 1009
Query: 1115 IQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWT 1174
I RA R T E +I NGL +GI +D IYWTD G N IEVA L+G R V++
Sbjct: 1010 ISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQ 1069
Query: 1175 GLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGR 1234
GLD PR+IA+H E G +FW++WG I +A +DG+ + V+V I WPNG++ID E +
Sbjct: 1070 GLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENK 1129
Query: 1235 LYWNDAKILTIESSDFD-GHDRRTVL--SNVPYPYGIVIVGQHIYWTD--WKTKALHRAD 1289
LYW DA+ IE D + G +R VL SNV + + G +IYW+D ++ R
Sbjct: 1130 LYWCDARTDKIERIDLETGGNREMVLSGSNVDM-FSVAXFGAYIYWSDRAHANGSVRRGH 1188
Query: 1290 KTNASDPIVIRKNL-EGLMDIRAIQSERVL-ENACGTDNGGCSHLCL-RSPLGYTCACPT 1346
K +A++ I +R L L +++ R N C DNGGC LCL R TCAC
Sbjct: 1189 KNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLYRGNSRRTCACAH 1248
Query: 1347 GMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKN------ 1400
G E T C H E +L+++ R + I L ++ ++ P++ +N
Sbjct: 1249 GYLAEDGVT------CLRH-EGYLLYSGRTILKSIHLS--DETNLNSPIRPYENPRYFKN 1299
Query: 1401 --TIAVDYHWDLK---MIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIAN 1455
+A DY+ K IFY+D I+ I + E + +I + + + GL +
Sbjct: 1300 VIALAFDYNQRRKGTNRIFYSDAHFGNIQLIK--DNWEDRQVIVENVGSVEGLAYHRAWD 1357
Query: 1456 NIYWTDN-----EHKVIEVARLDGSSRKVLITGLTE--PRALALFPAKGYLYWSDWGE-H 1507
+YWT + ++ R R+ +IT + P LAL + ++W++W E H
Sbjct: 1358 TLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQH 1417
Query: 1508 PYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQLV 1567
P I RS L G Q++V D+ PNGLTIDY+ +LY++D +I+ + +G R +V
Sbjct: 1418 PSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVIV 1477
Query: 1568 PDAKNPF-GMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNL-EMAMEIKAVSADRQ 1625
F + + +YI+W+DW +++I+R++K TG + ++R+++ M I AV+ D
Sbjct: 1478 KSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQPMGIIAVANDTN 1537
Query: 1626 H-GWNPCKESNGGCSHLCLFRGHEYI-CACPDD 1656
+PC NGGC LCL + + C+C D
Sbjct: 1538 SCELSPCALLNGGCHDLCLLTPNGRVNCSCRGD 1570
Score = 416 bits (1024), Expect = e-115
Identities = 256/779 (32%), Positives = 386/779 (49%), Gaps = 49/779 (6%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDED--SCPMV----PGSCNAGEFKCN-DGK 315
C + F C + +C+P + CDGDNDCGD++DE +C P CN EF+C+ DG
Sbjct: 82 CFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGN 141
Query: 316 CIPERWRCDNERDCADGGDELNCKPNSIRNCS-LDEYTC-ADRRCVLKTWLCDGVRDCTN 373
C+P+ WRCD E+DC DG DE C +IR C +++C + RC+ K W+CDG DC +
Sbjct: 142 CVPDLWRCDGEKDCEDGSDEKGCN-GTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCED 200
Query: 374 GEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKC 433
DE +C D + C P +H +N C+ + +C+G KDCP G DE L +C
Sbjct: 201 QSDEDDC------DSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGY--LCDEC 252
Query: 434 SAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGS 492
S C C C+CP G L +D +C +D C CSQ C +
Sbjct: 253 SLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLK--CSQVCEQHKHT 310
Query: 493 FRCGCMTGYILRPDERSCKPTGESPT-LLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALD 551
+C C G+ L D SC ++FS R IR++ L +Y +V GL N +ALD
Sbjct: 311 VKCSCYEGWKLDVDGESCTSVDSFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALD 370
Query: 552 YHYEKKLVFWSEN-NLRVIRVAQMNTKNMSD---VIRWGLETPAGVAVDWIHDLLFWTDS 607
+H+ + L++W++ R+ R + +S V+ GL TP G+ VDWI ++W DS
Sbjct: 371 FHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDS 430
Query: 608 GTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPN-PKIERADMDGDKR 666
++EVA LDGS R L+A ++ PRAIA+ P ++FWTDW N P+IE A M G R
Sbjct: 431 NLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGR 490
Query: 667 KTVIYD--EIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTT--KGLPHPFA 722
KT+ D WPNGLT+D+ E +I W DA+ I A +DG + ++ + L HPFA
Sbjct: 491 KTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFA 550
Query: 723 LTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDI---HSRSCEETPEKLLLY 779
++L+ +YWTDW T ++S NK TG + + P D+ H + P
Sbjct: 551 VSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAAN 610
Query: 780 ARRKDLRLKQLESKKPIDSLDMVIP-VETIKSAVALDWDQKSNSIF--WTDVEKDTINRA 836
+ L + S P + + S + K ++ +++ I+
Sbjct: 611 DGKGPCSHMCLINHN--RSAACACPHLMKLSSDKKTCYGMKKFLLYARRSEIRGVDIDNP 668
Query: 837 YLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGS-MRTLLAWDHID 895
Y N T+ D + + + FD +++YWTD T I+ + +G+ + T+++ D I
Sbjct: 669 YFNFITAFTVPDIDDV--TVIDFDASEERLYWTDIKTQTIKRAFINGTGLETVISRD-IQ 725
Query: 896 KPRDIVVNPEGGVMYW-SDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIY 954
R + V+ +YW S I A +DG + +I G + P LA V ++Y
Sbjct: 726 SIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSIIHG-IDKPQCLAAHPVRGKLY 784
Query: 955 WTDGGNKTIEYANLDGTGRTKLIENLPHPFGL--DLYGDEVFWTDWDTQSIQAANKDTG 1011
WTDG TI AN+DG+ L +N P GL D ++++W +I N D G
Sbjct: 785 WTDG--NTINMANMDGSNSKILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGG 841
Score = 345 bits (848), Expect = 9e-94
Identities = 209/646 (32%), Positives = 338/646 (52%), Gaps = 39/646 (6%)
Query: 1022 NNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCA--DGPINYLIFAHRVDIRVISLDVPY 1079
N+ CS +C C+C G KL+ DG++C D ++IF+ R +IR I L +
Sbjct: 296 NHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDSFEAFIIFSIRHEIRRIDL---H 352
Query: 1080 LIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRA--TRLG--THVETVIGNGLHT 1135
D L +P L+N + +D + L+YWTD + +I R + G + +E V+ +GL T
Sbjct: 353 KRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLAT 412
Query: 1136 ADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSD 1195
+G+ +D IYW D + IEVA+LDG R L+ ++ PRAIAL YG +FW+D
Sbjct: 413 PEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTD 472
Query: 1196 WGTS-AKIERADMDGNNRRVIV-DNKI-KWPNGLAIDRIEGRLYWNDAKILTIESSDFDG 1252
W + +IE A M G R+ I D K WPNGL +D E R+ W DA+ I S+ +DG
Sbjct: 473 WDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDG 532
Query: 1253 HDRRTVLSNVPY---PYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDI 1309
+ ++ Y P+ + + G +YWTDW+T L +A+K + VI+K D+
Sbjct: 533 TNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDL 592
Query: 1310 RAIQSERVLE--NACGTDN--GGCSHLCL-RSPLGYTCACPTGMPFEKSTTDQTPKKCKS 1364
+ R + N C ++ G CSH+CL CACP M K ++D+ K C
Sbjct: 593 QIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACPHLM---KLSSDK--KTCYG 647
Query: 1365 HPEEFLIFATRGSITYISLESPE-QWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVI 1423
++FL++A R I + +++P + V ++ + +D+ + +++TD+ I
Sbjct: 648 -MKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTI 706
Query: 1424 RSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNE--HKVIEVARLDGSSRKVLI 1481
+ N + +T+IS+ +++ GL VDW++ N+YW +E I VARLDGS + +I
Sbjct: 707 KRA-FINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSII 765
Query: 1482 TGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKER 1541
G+ +P+ LA P +G LYW+D I + +DGS +I+ Q + P GL+IDY E
Sbjct: 766 HGIDKPQCLAAHPVRGKLYWTDGNT---INMANMDGSNSKILFQ-NQKEPVGLSIDYVEN 821
Query: 1542 RLYWTDALKDRIDTSDLNGQHRVQLVPDAKNPF----GMTQFKDYIYWTDWYKKSIIRAD 1597
+LYW + I+ +L+G + ++++ K +T ++W D +
Sbjct: 822 KLYWISSGNGTINRCNLDGGN-LEVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCS 880
Query: 1598 KRTGKNITLIRTNLEMAMEIKAVSADRQHGWNPCKESNGGCSHLCL 1643
KR G+N T++R + +K + Q G N C+ +NGGCS LCL
Sbjct: 881 KRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLCL 926
Score = 191 bits (466), Expect = 2e-47
Identities = 106/286 (37%), Positives = 156/286 (54%), Gaps = 9/286 (3%)
Query: 482 CSQTCSNTVGSFR-CGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSV 540
CSQ C T + R C C GY L+ + SC+ G L++S GIR + L + M
Sbjct: 921 CSQLCLPTSETTRTCMCTVGYYLQKNRMSCQ--GIESFLMYSVHEGIRGIPLEPSDKMDA 978
Query: 541 ---VKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDW 597
+ G AV +D+H E ++W++ I A+ + D+I GL G+AVDW
Sbjct: 979 LMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDW 1038
Query: 598 IHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIE 657
I ++WTD G +EVA L+GS R V+++ LD+PR+IAVHP L+FWT+WG P I
Sbjct: 1039 IAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIG 1098
Query: 658 RADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFD-GRDRRKVTTKG 716
+A +DG ++ ++ I WPNG++IDY E+K+YW DA+ IER + G +R V +
Sbjct: 1099 KARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGS 1158
Query: 717 LPHPFALTLFDDAIYWTD-WHTK-SISTVNKNTGMGIQTVHAGLNV 760
F++ F IYW+D H S+ +KN T+ GL V
Sbjct: 1159 NVDMFSVAXFGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGV 1204
Score = 160 bits (389), Expect = 4e-38
Identities = 150/597 (25%), Positives = 253/597 (42%), Gaps = 51/597 (8%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C F C N +C+P+ + CD ++DCGD TDE + P +F C G+CI +W
Sbjct: 3 CQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQFVCKSGRCISSKWH 62
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDE--MNC 380
CD++ DC DG DE+ C + +C +++ C+ RC+ W CDG DC + DE +NC
Sbjct: 63 CDSDDDCGDGSDEVGC----VHSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINC 118
Query: 381 EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC-PLKRKCSAEEKC 439
C E + NCV CDG KDC G DE+ C R C + K
Sbjct: 119 TKEEIHSPAGCNGNE-FQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLC--DHKT 175
Query: 440 EKLCITTYDG-HAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCM 498
+ C +T + A C G + ED+ D D+C C+N C+
Sbjct: 176 KFSCWSTGRCINKAWVCD-GDIDCEDQ---SDEDDCDSFLCGPPKHPCANDTSV----CL 227
Query: 499 TGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVA----LDYHY 554
L ++ C P G L + + + N+ SVV G + L +
Sbjct: 228 QPEKLCNGKKDC-PDGSDEGYL-CDECSLNNGGCS--NHCSVVPGRGIVCSCPEGLQLNK 283
Query: 555 EKK---LVFWSENNLRVIRVAQM--NTKNMSDVIRWGLET--PAGVAVDWIHDLLFWTDS 607
+ K +V + N+L+ +V + +T S W L+ + +VD + +
Sbjct: 284 DNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDSFEAFIIF--- 340
Query: 608 GTRRVEVATLDGSKRAV-LVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDG--- 663
+ R E+ +D KR L+ L A+ H +L++WTD +I R +
Sbjct: 341 -SIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTD-VVEDRIYRGKLSESGG 398
Query: 664 -DKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFA 722
+ V+ + P GLT+D+ IYW D+ IE A DG R + + HP A
Sbjct: 399 VSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRA 458
Query: 723 LTLFD--DAIYWTDWHTKSISTVNKN-TGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLY 779
+ L ++WTDW + + +G G +T++ + + + + ++++
Sbjct: 459 IALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWT 518
Query: 780 ARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRA 836
R D L + ++++ E + A+ + ++WTD +T+++A
Sbjct: 519 DARSDAIYSALYD--GTNMIEIIRGHEYLSHPFAV--SLYGSEVYWTDWRTNTLSKA 571
Score = 151 bits (366), Expect = 2e-35
Identities = 159/659 (24%), Positives = 283/659 (42%), Gaps = 68/659 (10%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDE----CMYEQDPVCSQTCSNTVGSFR 494
C +LC+ T + C C +G+ L +++ SC+ I+ ++E S+ + +
Sbjct: 921 CSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMDALM 980
Query: 495 CGCMTGYILRPDERSCKPTGESPTLLFS--NRIGIRQVWLTGDNYMSVVKGLHNAVALDY 552
T + + D + T + F+ +R Q W ++ ++ G +A+D+
Sbjct: 981 PISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTW--KEDIITNGLGRVEGIAVDW 1038
Query: 553 HYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRR- 611
++W+++ +I VA++N +I GL+ P +AV LLFWT+ G
Sbjct: 1039 IAGN--IYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPC 1096
Query: 612 VEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMD-GDKRKTVI 670
+ A LDGS++ VLV+ + P I++ + ++W D KIER D++ G R+ V+
Sbjct: 1097 IGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCD-ARTDKIERIDLETGGNREMVL 1155
Query: 671 YDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAI 730
+ ++ + IYW+D H + G T + + L + I
Sbjct: 1156 SGSNV--DMFSVAXFGAYIYWSDRAH--ANGSVRRGHKNDATETITMRTGLGVNLKEVKI 1211
Query: 731 YWTDWHTKSISTVNKNTGMGIQTVHAG--LNVPMDIHSRSCEE-----TPEKLLLYARRK 783
+ + N G ++ G H E+ E LLY+ R
Sbjct: 1212 FNRVREKGTNVCARDNGGCKQLCLYRGNSRRTCACAHGYLAEDGVTCLRHEGYLLYSGRT 1271
Query: 784 DLRLKQLESKKPIDSLDMVIPVET---IKSAVAL--DWDQK---SNSIFWTDVEKDTINR 835
L+ L + ++S + P E K+ +AL D++Q+ +N IF++D I
Sbjct: 1272 ILKSIHLSDETNLNS--PIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNIQL 1329
Query: 836 AYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGS------MRTLL 889
N + IV+ N+ GLA+ D +YWT T+ I D + ++
Sbjct: 1330 IKDNWEDRQVIVE-NVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVI 1388
Query: 890 AWDHIDKPRDIVVNPEGGVMYWSDWGAS-PCIERADMDGGNRKKLIFGQMTWPNGLALDL 948
D P + ++ +M+W++W P I R+ + G N + ++ + PNGL +D
Sbjct: 1389 TMSEDDHPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDY 1448
Query: 949 VHNRIYWTDGGNKTIEYANLDGTGRTKLIENLPHPF-GLDLYGDEVFWTDWDTQSIQAAN 1007
++Y++DG IE DG+ R ++++ P F L +Y + +FW+DW ++I +N
Sbjct: 1449 RAEKLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSN 1508
Query: 1008 KDTGAKRRTL------------------------GCGKNNGGCSHLCLLKPGGR-SCAC 1041
K TG + L C NGGC LCLL P GR +C+C
Sbjct: 1509 KYTGGDTKILRSDIPHQPMGIIAVANDTNSCELSPCALLNGGCHDLCLLTPNGRVNCSC 1567
Score = 124 bits (299), Expect = 3e-27
Identities = 79/276 (28%), Positives = 138/276 (50%), Gaps = 16/276 (5%)
Query: 482 CSQTCS-NTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGD--NYM 538
CS C N S C C L D+++C G LL++ R IR V + N++
Sbjct: 616 CSHMCLINHNRSAACACPHLMKLSSDKKTCY--GMKKFLLYARRSEIRGVDIDNPYFNFI 673
Query: 539 SV--VKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVD 596
+ V + + +D+ ++ ++W++ + I+ A +N + VI +++ G+AVD
Sbjct: 674 TAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVD 733
Query: 597 WIHDLLFWTDS--GTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNP 654
W+ L+W S ++ VA LDGS + ++ + +DKP+ +A HP ++WTD
Sbjct: 734 WVSRNLYWISSEFDETQINVARLDGSLKTSII-HGIDKPQCLAAHPVRGKLYWTD---GN 789
Query: 655 KIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTT 714
I A+MDG K +++ P GL+IDY E+K+YW + + I R DG + + +
Sbjct: 790 TINMANMDGSNSK-ILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIES 848
Query: 715 --KGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTG 748
+ L ALT+ D ++W D + + T +K G
Sbjct: 849 MKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDG 884
Score = 94.7 bits (225), Expect = 3e-18
Identities = 43/114 (37%), Positives = 58/114 (50%), Gaps = 3/114 (2%)
Query: 267 DFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNE 326
+FEC N +C+ CDG C D +DE SC G C + +CIP CD E
Sbjct: 1591 EFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGE 1650
Query: 327 RDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC 380
DC D DEL+CK + C+ E+ CAD C+ ++ C+ DC + DE NC
Sbjct: 1651 NDCGDNSDELDCK---VSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNC 1701
Score = 90.2 bits (214), Expect = 6e-17
Identities = 80/290 (27%), Positives = 137/290 (47%), Gaps = 23/290 (7%)
Query: 1019 CGKNNGGCSHLCLLKPG-GRSCACPIGIKLNKDGKTC--ADGPINYLIFAHRVDIRVISL 1075
C NNGGCS+ C + PG G C+CP G++LNKD KTC D N+L + + ++
Sbjct: 252 CSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTV 311
Query: 1076 DVPYLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHT 1135
L + ++ VD +I+ R+I L +++ GL
Sbjct: 312 KCSCYEGWKLDVDG-ESCTSVD-SFEAFIIFSIRHEIRRID----LHKRDYSLLVPGLRN 365
Query: 1136 ADGIVIDSTGRKIYWTDGGRNSI---EVAELDGRNR-KVLVWTGLDSPRAIALHYEYGYM 1191
+ +YWTD + I +++E G + +V+V GL +P + + + G +
Sbjct: 366 TIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNI 425
Query: 1192 FWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWN--DAKILTIESSD 1249
+W D +IE A +DG+ R ++ ++ P +A+D G L+W DA IES+
Sbjct: 426 YWID-SNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESAS 484
Query: 1250 FDGHDRRTVLSNV---PYPYGIVI--VGQHIYWTDWKTKALHRA--DKTN 1292
G R+T+ ++ +P G+ + + I WTD ++ A++ A D TN
Sbjct: 485 MSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTN 534
Score = 80.2 bits (189), Expect = 6e-14
Identities = 47/138 (34%), Positives = 67/138 (48%), Gaps = 14/138 (10%)
Query: 293 DEDSCPMVPGSCNA-GEFKCNDGKCIPERWRCDNERDCADGGDE--LNCKPNSIRNCSLD 349
+++ C SCNA EF+C +G+CI + CD C D DE L C+ R+C
Sbjct: 1575 EDNRCVTKNSSCNAYSEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCEN---RSCRRG 1631
Query: 350 EYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRK 409
C +RRC+ LCDG DC + DE++C+VS TC E ++ C+ R
Sbjct: 1632 FKPCYNRRCIPHGKLCDGENDCGDNSDELDCKVS------TCATVEFRCADG--TCIPRS 1683
Query: 410 HVCDGMKDCPRGDDEERC 427
C+ DC DE+ C
Sbjct: 1684 ARCNQNIDCADASDEKNC 1701
Score = 79.8 bits (188), Expect = 8e-14
Identities = 65/226 (28%), Positives = 98/226 (43%), Gaps = 24/226 (10%)
Query: 162 ENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPT 221
+N+ C S+ CI W CDGDNDCGDFSDE + K + P A N + +P
Sbjct: 84 DNQFRC-SSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSP---AGCNGNEFQCHP- 138
Query: 222 VLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNT-KCVPKDF 280
V +K ++ ++ + N + L + F C +T +C+ K +
Sbjct: 139 ------DGNCVPDLWRCDGEKDCEDGSDEKGC-NGTIRLCD-HKTKFSCWSTGRCINKAW 190
Query: 281 QCDGDNDCGDWTDEDSCPMVPGSCNAGEFKC-ND-GKCIPERWRCDNERDCADGGDELNC 338
CDGD DC D +DED C C + C ND C+ C+ ++DC DG DE
Sbjct: 191 VCDGDIDCEDQSDEDDCDSF--LCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDE--- 245
Query: 339 KPNSIRNCSLDEYTCADRRCVL--KTWLCDGVRDCTNGEDEMNCEV 382
CSL+ C++ V+ + +C +D CE+
Sbjct: 246 -GYLCDECSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEI 290
Score = 70.1 bits (164), Expect = 7e-11
Identities = 80/310 (25%), Positives = 129/310 (41%), Gaps = 26/310 (8%)
Query: 1301 KNLEGLMDIRAIQSERVLENACGTDNGGCSHLCLRSP-LGYTCACPTGMPFEK-STTDQT 1358
K G D E L + C +NGGCS+ C P G C+CP G+ K + T +
Sbjct: 231 KLCNGKKDCPDGSDEGYLCDECSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEI 290
Query: 1359 PKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDL 1418
C +H + + + E W + + + ++ +VD ++ +IF
Sbjct: 291 VDYCSNHLKCSQVCEQHKHT--VKCSCYEGWKLDV---DGESCTSVD-SFEAFIIFSI-- 342
Query: 1419 DLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSS-- 1476
+ IR I++ S ++ L L + + +YWTD I +L S
Sbjct: 343 -RHEIRRIDLHKRDYS--LLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGV 399
Query: 1477 ---RKVLITGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNG 1533
V+ GL P L + G +YW D IE + LDGS R ++ + P
Sbjct: 400 SAIEVVVEHGLATPEGLTVDWIAGNIYWID-SNLDQIEVAKLDGSLRTTLIAGAMEHPRA 458
Query: 1534 LTIDYKERRLYWT--DALKDRIDTSDLNGQHRVQLVPDAKN---PFGMT--QFKDYIYWT 1586
+ +D + L+WT DA RI+++ ++G R + D K P G+T F+ I WT
Sbjct: 459 IALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWT 518
Query: 1587 DWYKKSIIRA 1596
D +I A
Sbjct: 519 DARSDAIYSA 528
Score = 50.4 bits (115), Expect = 6e-05
Identities = 22/41 (53%), Positives = 26/41 (63%), Gaps = 1/41 (2%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCD 196
R CD H+ + C ST CI W+CDGD DC D SDE +CD
Sbjct: 169 RLCD-HKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCD 208
Score = 48.4 bits (110), Expect = 2e-04
Identities = 48/186 (25%), Positives = 75/186 (40%), Gaps = 21/186 (11%)
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSI--RNCSLDE 350
D +SC + P C C+D + R + C+ GD + + N +N S +
Sbjct: 1535 DTNSCELSP--CALLNGGCHDLCLLTPNGRVN----CSCRGDRILLEDNRCVTKNSSCNA 1588
Query: 351 YT---CADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVN 407
Y+ C + C+ CDG+ C + DE + CE +CR N R C+
Sbjct: 1589 YSEFECGNGECIDYQLTCDGIPHCKDKSDEKL--LYCENR--SCRRGFKPCYN--RRCIP 1642
Query: 408 RKHVCDGMKDCPRGDDEERCPLKRKCSAEEKC-EKLCITTYDGHAACACPMGFLLAEDKY 466
+CDG DC DE C + + E +C + CI A C + A D+
Sbjct: 1643 HGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPR---SARCNQNIDCADASDEK 1699
Query: 467 SCRDID 472
+C + D
Sbjct: 1700 NCNNTD 1705
Score = 42.7 bits (96), Expect = 0.012
Identities = 16/30 (53%), Positives = 21/30 (70%), Gaps = 1/30 (3%)
Query: 166 ICHSTNVCIALEWLCDGDNDCGDFSDEINC 195
+C S CI+ +W CD D+DCGD SDE+ C
Sbjct: 50 VCKSGR-CISSKWHCDSDDDCGDGSDEVGC 78
Score = 41.9 bits (94), Expect = 0.020
Identities = 13/35 (37%), Positives = 23/35 (65%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSC 297
CA ++F C + C+P+ +C+ + DC D +DE +C
Sbjct: 1667 CATVEFRCADGTCIPRSARCNQNIDCADASDEKNC 1701
Score = 40.7 bits (91), Expect = 0.046
Identities = 16/25 (64%), Positives = 19/25 (76%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDV 197
CI LCDG+NDCGD SDE++C V
Sbjct: 1640 CIPHGKLCDGENDCGDNSDELDCKV 1664
Score = 35.5 bits (78), Expect = 1.7
Identities = 13/25 (52%), Positives = 19/25 (76%), Gaps = 1/25 (4%)
Query: 173 CIALEWLCDGDNDCGDFSDEI-NCD 196
CI WLCD ++DCGD +DE+ +C+
Sbjct: 15 CIPRAWLCDREDDCGDQTDEMASCE 39
>AC010740-1|AAY14689.1| 862|Homo sapiens unknown protein.
Length = 862
Score = 417 bits (1026), Expect = e-115
Identities = 256/779 (32%), Positives = 387/779 (49%), Gaps = 49/779 (6%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDED--SCPMV----PGSCNAGEFKCN-DGK 315
C + F C + +C+P + CDGDNDCGD++DE +C P CN EF+C+ DG
Sbjct: 82 CFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGN 141
Query: 316 CIPERWRCDNERDCADGGDELNCKPNSIRNCS-LDEYTC-ADRRCVLKTWLCDGVRDCTN 373
C+P+ WRCD E+DC DG DE C +IR C +++C + RC+ K W+CDG DC +
Sbjct: 142 CVPDLWRCDGEKDCEDGSDEKGCN-GTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCED 200
Query: 374 GEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKC 433
DE +C D + C P +H +N C+ + +C+G KDCP G DE L +C
Sbjct: 201 QSDEDDC------DSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGY--LCDEC 252
Query: 434 SAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGS 492
S C C C+CP G L +D +C +D C CSQ C +
Sbjct: 253 SLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLK--CSQVCEQHKHT 310
Query: 493 FRCGCMTGYILRPDERSCKPTGESPT-LLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALD 551
+C C G+ L D SC ++FS R IR++ L +Y +V GL N +ALD
Sbjct: 311 VKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALD 370
Query: 552 YHYEKKLVFWSEN-NLRVIRVAQMNTKNMSD---VIRWGLETPAGVAVDWIHDLLFWTDS 607
+H+ + L++W++ R+ R + +S V+ GL TP G+ VDWI ++W DS
Sbjct: 371 FHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDS 430
Query: 608 GTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPN-PKIERADMDGDKR 666
++EVA LDGS R L+A ++ PRAIA+ P ++FWTDW N P+IE A M G R
Sbjct: 431 NLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGR 490
Query: 667 KTVIYD--EIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTT--KGLPHPFA 722
KT+ D WPNGLT+D+ E +I W DA+ I A +DG + ++ + L HPFA
Sbjct: 491 KTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFA 550
Query: 723 LTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDI---HSRSCEETPEKLLLY 779
++L+ +YWTDW T ++S NK TG + + P D+ H + P
Sbjct: 551 VSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAAN 610
Query: 780 ARRKDLRLKQLESKKPIDSLDMVIP-VETIKSAVALDWDQKSNSIF--WTDVEKDTINRA 836
+ L + S P + + S ++ K ++ +++ I+
Sbjct: 611 DGKGPCSHMCLINHN--RSAACACPHLMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNP 668
Query: 837 YLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGS-MRTLLAWDHID 895
Y N T+ D + + + FD +++YWTD T I+ + +G+ + T+++ D I
Sbjct: 669 YFNFITAFTVPDIDDV--TVIDFDASEERLYWTDIKTQTIKRAFINGTGLETVISRD-IQ 725
Query: 896 KPRDIVVNPEGGVMYW-SDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIY 954
R + V+ +YW S I A +DG + +I G + P LA V ++Y
Sbjct: 726 SIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSIIHG-IDKPQCLAAHPVRGKLY 784
Query: 955 WTDGGNKTIEYANLDGTGRTKLIENLPHPFGL--DLYGDEVFWTDWDTQSIQAANKDTG 1011
WTDG TI AN+DG+ L +N P GL D ++++W +I N D G
Sbjct: 785 WTDG--NTINMANMDGSNSKILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGG 841
Score = 307 bits (753), Expect = 3e-82
Identities = 186/559 (33%), Positives = 297/559 (53%), Gaps = 34/559 (6%)
Query: 1022 NNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD-GPIN-YLIFAHRVDIRVISLDVPY 1079
N+ CS +C C+C G KL+ DG++C P ++IF+ R +IR I L +
Sbjct: 296 NHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDL---H 352
Query: 1080 LIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRA--TRLG--THVETVIGNGLHT 1135
D L +P L+N + +D + L+YWTD + +I R + G + +E V+ +GL T
Sbjct: 353 KRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLAT 412
Query: 1136 ADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSD 1195
+G+ +D IYW D + IEVA+LDG R L+ ++ PRAIAL YG +FW+D
Sbjct: 413 PEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTD 472
Query: 1196 WGTS-AKIERADMDGNNRRVIV-DNKI-KWPNGLAIDRIEGRLYWNDAKILTIESSDFDG 1252
W + +IE A M G R+ I D K WPNGL +D E R+ W DA+ I S+ +DG
Sbjct: 473 WDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDG 532
Query: 1253 HDRRTVLSNVPY---PYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDI 1309
+ ++ Y P+ + + G +YWTDW+T L +A+K + VI+K D+
Sbjct: 533 TNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDL 592
Query: 1310 RAIQSERVLE--NACGTDN--GGCSHLCL-RSPLGYTCACPTGMPFEKSTTDQTPKKCKS 1364
+ R + N C ++ G CSH+CL CACP M K ++D KK
Sbjct: 593 QIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACPHLM---KLSSD---KKTCY 646
Query: 1365 HPEEFLIFATRGSITYISLESPE-QWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVI 1423
++FL++A R I + +++P + V ++ + +D+ + +++TD+ I
Sbjct: 647 EMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTI 706
Query: 1424 RSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNE--HKVIEVARLDGSSRKVLI 1481
+ N + +T+IS+ +++ GL VDW++ N+YW +E I VARLDGS + +I
Sbjct: 707 KRA-FINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSII 765
Query: 1482 TGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKER 1541
G+ +P+ LA P +G LYW+D I + +DGS +I+ Q + P GL+IDY E
Sbjct: 766 HGIDKPQCLAAHPVRGKLYWTDGNT---INMANMDGSNSKILFQ-NQKEPVGLSIDYVEN 821
Query: 1542 RLYWTDALKDRIDTSDLNG 1560
+LYW + I+ +L+G
Sbjct: 822 KLYWISSGNGTINRCNLDG 840
Score = 305 bits (750), Expect = 7e-82
Identities = 185/540 (34%), Positives = 282/540 (52%), Gaps = 53/540 (9%)
Query: 762 MDIHSRSCEETP--EKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQK 819
+D+ SC E ++++ R ++R L + D + V +++ +ALD+
Sbjct: 321 LDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKR------DYSLLVPGLRNTIALDFHFN 374
Query: 820 SNSIFWTDVEKDTINRAYLNGSHQTT----IVDSNLIWPAGLAFDWITDKIYWTDGGTNR 875
+ ++WTDV +D I R L+ S + +V+ L P GL DWI IYW D ++
Sbjct: 375 QSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQ 434
Query: 876 IEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGAS-PCIERADMDGGNRKKLI 934
IEV+K DGS+RT L ++ PR I ++P G+++W+DW A+ P IE A M G RK +
Sbjct: 435 IEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIY 494
Query: 935 FGQMT--WPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLI---ENLPHPFGLDLY 989
T WPNGL +D RI WTD + I A DGT ++I E L HPF + LY
Sbjct: 495 KDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLY 554
Query: 990 GDEVFWTDWDTQSIQAANKDTGAK----RRTLG-------------------CGKNNGG- 1025
G EV+WTDW T ++ ANK TG ++T C N+G
Sbjct: 555 GSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKG 614
Query: 1026 -CSHLCLLKPG-GRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPYLIDV 1083
CSH+CL+ +CACP +KL+ D KTC + +L++A R +IR + +D PY +
Sbjct: 615 PCSHMCLINHNRSAACACPHLMKLSSDKKTCYEMK-KFLLYARRSEIRGVDIDNPYFNFI 673
Query: 1084 V-LPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVID 1142
+P + + +D D S +YWTD + I+RA GT +ETVI + + G+ +D
Sbjct: 674 TAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVD 733
Query: 1143 STGRKIYW--TDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSA 1200
R +YW ++ I VA LDG + K + G+D P+ +A H G ++W+D T
Sbjct: 734 WVSRNLYWISSEFDETQINVARLDG-SLKTSIIHGIDKPQCLAAHPVRGKLYWTDGNT-- 790
Query: 1201 KIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLS 1260
I A+MDG+N +++ N+ K P GL+ID +E +LYW + TI + DG + + S
Sbjct: 791 -INMANMDGSNSKILFQNQ-KEPVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIES 848
Score = 205 bits (500), Expect = 1e-51
Identities = 127/376 (33%), Positives = 203/376 (53%), Gaps = 29/376 (7%)
Query: 1329 CSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKS-HP-EEFLIFATRGSITYISLESP 1386
CS +C + C+C +E D + C S P E F+IF+ R I I L
Sbjct: 300 CSQVCEQHKHTVKCSC-----YEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKR 354
Query: 1387 EQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTN---MSESKTIISQKLE 1443
D +L V ++NTIA+D+H++ ++++TD+ + I ++ +S + ++ L
Sbjct: 355 ---DYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLA 411
Query: 1444 TPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITGLTE-PRALALFPAKGYLYWS 1502
TP GL VDWIA NIYW D+ IEVA+LDGS R LI G E PRA+AL P G L+W+
Sbjct: 412 TPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWT 471
Query: 1503 DWGEH-PYIERSYLDGSQRQIIVQ-VDLG-FPNGLTIDYKERRLYWTDALKDRIDTSDLN 1559
DW + P IE + + G+ R+ I + + G +PNGLT+D+ E+R+ WTDA D I ++ +
Sbjct: 472 DWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYD 531
Query: 1560 GQHRVQLVPDAK---NPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAME 1616
G + ++++ + +PF ++ + +YWTDW ++ +A+K TG+N+++I+ +
Sbjct: 532 GTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFD 591
Query: 1617 IKAVSADRQ-HGWNPC--KESNGGCSHLCLF-RGHEYICACPD----DPDHVECSTVKML 1668
++ RQ NPC + G CSH+CL CACP D C +K
Sbjct: 592 LQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACPHLMKLSSDKKTCYEMKKF 651
Query: 1669 RNY-RDTELKDEEFSN 1683
Y R +E++ + N
Sbjct: 652 LLYARRSEIRGVDIDN 667
Score = 180 bits (438), Expect = 4e-44
Identities = 120/439 (27%), Positives = 210/439 (47%), Gaps = 31/439 (7%)
Query: 559 VFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTD--SGTRRVEVAT 616
++W ++NL I VA+++ + +I +E P +A+D + +LFWTD + R+E A+
Sbjct: 425 IYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESAS 484
Query: 617 LDGSKRAVLVANDLDK---PRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDE 673
+ G+ R + D+ P + V + + WTD + I A DG +I
Sbjct: 485 MSGAGRKTIY-KDMKTGAWPNGLTVDHFEKRIVWTD-ARSDAIYSALYDGTNMIEIIRGH 542
Query: 674 IFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDD----- 728
+ + + S++YW D + + + +A V K PF L ++
Sbjct: 543 EYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQ 602
Query: 729 -----AIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRK 783
A + +N N H + + ++C E +K LLYARR
Sbjct: 603 APNPCAANDGKGPCSHMCLINHNRSAACACPHL---MKLSSDKKTCYEM-KKFLLYARRS 658
Query: 784 DLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQ 843
++R +++ P + V I +D+D ++WTD++ TI RA++NG+
Sbjct: 659 EIRGVDIDN--PYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGTGL 716
Query: 844 TTIVDSNLIWPAGLAFDWITDKIYW--TDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIV 901
T++ ++ GLA DW++ +YW ++ +I V++ DGS++T + IDKP+ +
Sbjct: 717 ETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSII-HGIDKPQCLA 775
Query: 902 VNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNK 961
+P G +YW+D I A+MDG N K++F P GL++D V N++YW GN
Sbjct: 776 AHPVRGKLYWTDGNT---INMANMDGSN-SKILFQNQKEPVGLSIDYVENKLYWISSGNG 831
Query: 962 TIEYANLDGTGRTKLIENL 980
TI NLDG G ++IE++
Sbjct: 832 TINRCNLDG-GNLEVIESM 849
Score = 160 bits (389), Expect = 4e-38
Identities = 151/599 (25%), Positives = 256/599 (42%), Gaps = 52/599 (8%)
Query: 262 RCAEID-FECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPER 320
R ++D F C N +C+P+ + CD ++DCGD TDE + P +F C G+CI +
Sbjct: 1 RTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQFVCKSGRCISSK 60
Query: 321 WRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDE--M 378
W CD++ DC DG DE+ C + +C +++ C+ RC+ W CDG DC + DE +
Sbjct: 61 WHCDSDDDCGDGSDEVGC----VHSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQI 116
Query: 379 NCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC-PLKRKCSAEE 437
NC C E + NCV CDG KDC G DE+ C R C +
Sbjct: 117 NCTKEEIHSPAGCNGNE-FQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLC--DH 173
Query: 438 KCEKLCITTYDG-HAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCG 496
K + C +T + A C G + ED+ D D+C C+N
Sbjct: 174 KTKFSCWSTGRCINKAWVCD-GDIDCEDQ---SDEDDCDSFLCGPPKHPCANDTSV---- 225
Query: 497 CMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVA----LDY 552
C+ L ++ C P G L + + + N+ SVV G + L
Sbjct: 226 CLQPEKLCNGKKDC-PDGSDEGYL-CDECSLNNGGCS--NHCSVVPGRGIVCSCPEGLQL 281
Query: 553 HYEKK---LVFWSENNLRVIRVAQM--NTKNMSDVIRWGLET--PAGVAVDWIHDLLFWT 605
+ + K +V + N+L+ +V + +T S W L+ + +VD + +
Sbjct: 282 NKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDPFEAFIIF- 340
Query: 606 DSGTRRVEVATLDGSKRAV-LVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDG- 663
+ R E+ +D KR L+ L A+ H +L++WTD +I R +
Sbjct: 341 ---SIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTD-VVEDRIYRGKLSES 396
Query: 664 ---DKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHP 720
+ V+ + P GLT+D+ IYW D+ IE A DG R + + HP
Sbjct: 397 GGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHP 456
Query: 721 FALTLFD--DAIYWTDWHTKSISTVNKN-TGMGIQTVHAGLNVPMDIHSRSCEETPEKLL 777
A+ L ++WTDW + + +G G +T++ + + + + ++++
Sbjct: 457 RAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIV 516
Query: 778 LYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRA 836
R D L + ++++ E + A+ + ++WTD +T+++A
Sbjct: 517 WTDARSDAIYSALYD--GTNMIEIIRGHEYLSHPFAV--SLYGSEVYWTDWRTNTLSKA 571
Score = 89.8 bits (213), Expect = 8e-17
Identities = 80/290 (27%), Positives = 137/290 (47%), Gaps = 23/290 (7%)
Query: 1019 CGKNNGGCSHLCLLKPG-GRSCACPIGIKLNKDGKTC--ADGPINYLIFAHRVDIRVISL 1075
C NNGGCS+ C + PG G C+CP G++LNKD KTC D N+L + + ++
Sbjct: 252 CSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTV 311
Query: 1076 DVPYLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHT 1135
L + ++ VD +I+ R+I L +++ GL
Sbjct: 312 KCSCYEGWKLDVDG-ESCTSVD-PFEAFIIFSIRHEIRRID----LHKRDYSLLVPGLRN 365
Query: 1136 ADGIVIDSTGRKIYWTDGGRNSI---EVAELDGRNR-KVLVWTGLDSPRAIALHYEYGYM 1191
+ +YWTD + I +++E G + +V+V GL +P + + + G +
Sbjct: 366 TIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNI 425
Query: 1192 FWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWN--DAKILTIESSD 1249
+W D +IE A +DG+ R ++ ++ P +A+D G L+W DA IES+
Sbjct: 426 YWID-SNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESAS 484
Query: 1250 FDGHDRRTVLSNV---PYPYGIVI--VGQHIYWTDWKTKALHRA--DKTN 1292
G R+T+ ++ +P G+ + + I WTD ++ A++ A D TN
Sbjct: 485 MSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTN 534
Score = 79.8 bits (188), Expect = 8e-14
Identities = 65/226 (28%), Positives = 98/226 (43%), Gaps = 24/226 (10%)
Query: 162 ENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPT 221
+N+ C S+ CI W CDGDNDCGDFSDE + K + P A N + +P
Sbjct: 84 DNQFRC-SSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSP---AGCNGNEFQCHP- 138
Query: 222 VLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNT-KCVPKDF 280
V +K ++ ++ + N + L + F C +T +C+ K +
Sbjct: 139 ------DGNCVPDLWRCDGEKDCEDGSDEKGC-NGTIRLCD-HKTKFSCWSTGRCINKAW 190
Query: 281 QCDGDNDCGDWTDEDSCPMVPGSCNAGEFKC-ND-GKCIPERWRCDNERDCADGGDELNC 338
CDGD DC D +DED C C + C ND C+ C+ ++DC DG DE
Sbjct: 191 VCDGDIDCEDQSDEDDCDSF--LCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDE--- 245
Query: 339 KPNSIRNCSLDEYTCADRRCVL--KTWLCDGVRDCTNGEDEMNCEV 382
CSL+ C++ V+ + +C +D CE+
Sbjct: 246 -GYLCDECSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEI 290
Score = 69.7 bits (163), Expect = 9e-11
Identities = 80/310 (25%), Positives = 129/310 (41%), Gaps = 26/310 (8%)
Query: 1301 KNLEGLMDIRAIQSERVLENACGTDNGGCSHLCLRSP-LGYTCACPTGMPFEK-STTDQT 1358
K G D E L + C +NGGCS+ C P G C+CP G+ K + T +
Sbjct: 231 KLCNGKKDCPDGSDEGYLCDECSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEI 290
Query: 1359 PKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDL 1418
C +H + + + E W + + + ++ +VD ++ +IF
Sbjct: 291 VDYCSNHLKCSQVCEQHKHT--VKCSCYEGWKLDV---DGESCTSVD-PFEAFIIFSI-- 342
Query: 1419 DLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSS-- 1476
+ IR I++ S ++ L L + + +YWTD I +L S
Sbjct: 343 -RHEIRRIDLHKRDYS--LLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGV 399
Query: 1477 ---RKVLITGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNG 1533
V+ GL P L + G +YW D IE + LDGS R ++ + P
Sbjct: 400 SAIEVVVEHGLATPEGLTVDWIAGNIYWID-SNLDQIEVAKLDGSLRTTLIAGAMEHPRA 458
Query: 1534 LTIDYKERRLYWT--DALKDRIDTSDLNGQHRVQLVPDAKN---PFGMT--QFKDYIYWT 1586
+ +D + L+WT DA RI+++ ++G R + D K P G+T F+ I WT
Sbjct: 459 IALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWT 518
Query: 1587 DWYKKSIIRA 1596
D +I A
Sbjct: 519 DARSDAIYSA 528
Score = 50.4 bits (115), Expect = 6e-05
Identities = 22/41 (53%), Positives = 26/41 (63%), Gaps = 1/41 (2%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCD 196
R CD H+ + C ST CI W+CDGD DC D SDE +CD
Sbjct: 169 RLCD-HKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCD 208
Score = 49.2 bits (112), Expect = 1e-04
Identities = 27/109 (24%), Positives = 53/109 (48%), Gaps = 5/109 (4%)
Query: 532 LTGDNYMSVVKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPA 591
L G S++ G+ L H + ++W++ N I +A M+ N S ++ + P
Sbjct: 756 LDGSLKTSIIHGIDKPQCLAAHPVRGKLYWTDGN--TINMANMDGSN-SKILFQNQKEPV 812
Query: 592 GVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVL--VANDLDKPRAIAV 638
G+++D++ + L+W SG + LDG V+ + +L K A+ +
Sbjct: 813 GLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTI 861
Score = 44.0 bits (99), Expect = 0.005
Identities = 20/57 (35%), Positives = 33/57 (57%), Gaps = 1/57 (1%)
Query: 1425 SINMTNMSESKT-IISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVL 1480
+INM NM S + I+ Q + P GL +D++ N +YW + + I LDG + +V+
Sbjct: 790 TINMANMDGSNSKILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVI 846
Score = 42.7 bits (96), Expect = 0.012
Identities = 16/30 (53%), Positives = 21/30 (70%), Gaps = 1/30 (3%)
Query: 166 ICHSTNVCIALEWLCDGDNDCGDFSDEINC 195
+C S CI+ +W CD D+DCGD SDE+ C
Sbjct: 50 VCKSGR-CISSKWHCDSDDDCGDGSDEVGC 78
Score = 38.7 bits (86), Expect = 0.19
Identities = 25/82 (30%), Positives = 37/82 (45%), Gaps = 3/82 (3%)
Query: 1103 GLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAE 1162
G +YWTD I A G++ + + N G+ ID K+YW G +I
Sbjct: 781 GKLYWTDGNT--INMANMDGSNSKILFQNQKEPV-GLSIDYVENKLYWISSGNGTINRCN 837
Query: 1163 LDGRNRKVLVWTGLDSPRAIAL 1184
LDG N +V+ + +A AL
Sbjct: 838 LDGGNLEVIESMKEELTKATAL 859
Score = 35.5 bits (78), Expect = 1.7
Identities = 13/25 (52%), Positives = 19/25 (76%), Gaps = 1/25 (4%)
Query: 173 CIALEWLCDGDNDCGDFSDEI-NCD 196
CI WLCD ++DCGD +DE+ +C+
Sbjct: 15 CIPRAWLCDREDDCGDQTDEMASCE 39
>AB209498-1|BAD92735.1| 2359|Homo sapiens low density
lipoprotein-related protein 1 variant protein.
Length = 2359
Score = 406 bits (999), Expect = e-112
Identities = 203/513 (39%), Positives = 291/513 (56%), Gaps = 17/513 (3%)
Query: 263 CAEIDFECKNTK-CVPKDFQCDGDNDCGDWTDEDSCP--MVPGSCNAGEFKCNDGKCIPE 319
C F C T CVP+ + CDGD DC D DE + +C+ EF C + +CIP+
Sbjct: 590 CGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQNRQCIPK 649
Query: 320 RWRCDNERDCADGGDEL-NCKPNSIRNCSLDEYTCADRRCVL-KTWLCDGVRDCTNGEDE 377
+ CD++RDCADG DE C+ C E+ CA+ RC+ + W CDG DC + DE
Sbjct: 650 HFVCDHDRDCADGSDESPECE---YPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDE 706
Query: 378 MNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAE- 436
C ++ C + ++ R CV +C+G DC DE C + S +
Sbjct: 707 APKNPHCTSPEHKCNASSQFLCSSGR-CVAEALLCNGQDDCGDSSDERGCHINECLSRKL 765
Query: 437 EKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCG 496
C + C G C C GF L +D +C D+DEC CSQ C NT GS++C
Sbjct: 766 SGCSQDCEDLKIGFK-CRCRPGFRLKDDGRTCADVDECSTTFP--CSQRCINTHGSYKCL 822
Query: 497 CMTGYILRP-DERSCKP-TGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHY 554
C+ GY R D SCK T E P L+F+NR +R++ L G NY + +GL+NAVALD+ Y
Sbjct: 823 CVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDY 882
Query: 555 EKKLVFWSENNLR--VIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRV 612
+++++W++ + +IR +N N+ + R GL P G+AVDW+ L+W D G +
Sbjct: 883 REQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTI 942
Query: 613 EVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYD 672
EV+ L+G+ R VLV++ L +PRA+ V + ++WTDWG + I R MDG R ++
Sbjct: 943 EVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDT 1002
Query: 673 EIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYW 732
+I WPNGLT+DY +IYWADA+ IE A+ DG +R V ++ +PH FALTLF+D +YW
Sbjct: 1003 KITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYW 1062
Query: 733 TDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIH 765
TDW TKSI+ +K TG + + L+ PMD+H
Sbjct: 1063 TDWETKSINRAHKTTGTNKTLLISTLHRPMDLH 1095
Score = 281 bits (689), Expect = 2e-74
Identities = 172/543 (31%), Positives = 266/543 (48%), Gaps = 39/543 (7%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
RC F+CK+ C+P ++CD D DC D +DE++C +C EF+CN+ C P W
Sbjct: 1428 RCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAW 1487
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDE-YTCA-DRRCVLKTWLCDGVRDCTNGEDEMN 379
+CD E DC D DE N + + C + + C DR C+ CDG +C +G DE +
Sbjct: 1488 KCDGEDDCGDNSDE-NPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEED 1546
Query: 380 CEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRK---CSAE 436
CE + +E L N + C++ C+ DC G DEE C + K C+
Sbjct: 1547 CEPPTAHTTHCKDKKEFLCRN--QRCLSSLR-CNMFDDCGDGSDEEDCSIDPKLTSCATN 1603
Query: 437 EK-C--EKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSF 493
C E C+ T + A CAC GF + C+DI+EC+ + CSQ C+NT G
Sbjct: 1604 ASICGDEARCVRT-EKAAYCACRSGFHTVPGQPGCQDINECL--RFGTCSQLCNNTKGGH 1660
Query: 494 RCGCMTGYILRPDERSCKPTG-ESPTLLFSNRIGIRQVWLTGDN--YMSVVKGLHNAV-- 548
C C ++ +CK G E L ++ IR ++ + Y +G +
Sbjct: 1661 LCSCARNFM--KTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGDESVRID 1718
Query: 549 ALDYHYEKKLVFWSENNLRVIRVAQM--------NTKNMSDVIRW-------GLETPAGV 593
A+D H + V+W+ + I + + ++ + R GL+ P G+
Sbjct: 1719 AMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGI 1778
Query: 594 AVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPN 653
A+DW+ ++WTDSG +EVA + G R L++ +D+P AI V P ++W+DWG +
Sbjct: 1779 AIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNH 1838
Query: 654 PKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDR--RK 711
PKIE A MDG R+T++ D I WP GL +DY ++YWADAK VI +G D
Sbjct: 1839 PKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAA 1898
Query: 712 VTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEE 771
+ +GL HPF++ +F+D IY + + ++K + + GL+ D+ +
Sbjct: 1899 DSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHK 1958
Query: 772 TPE 774
PE
Sbjct: 1959 QPE 1961
Score = 253 bits (619), Expect = 5e-66
Identities = 136/335 (40%), Positives = 198/335 (59%), Gaps = 17/335 (5%)
Query: 1329 CSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEE--FLIFATRGSITYISLESP 1386
CS C+ + Y C C G + P CK+ +E FLIFA R + ++L+
Sbjct: 808 CSQRCINTHGSYKCLCVEGY----APRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGS 863
Query: 1387 EQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDL--NVIRSINMTNMSESKTIISQKLET 1444
+ TL + + N +A+D+ + +MI++TD+ ++IR +++ N S + + L
Sbjct: 864 ---NYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHL-NGSNVQVLHRTGLSN 919
Query: 1445 PNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLIT-GLTEPRALALFPAKGYLYWSD 1503
P+GL VDW+ N+YW D IEV++L+G+ R VL++ GL EPRAL + GYLYW+D
Sbjct: 920 PDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTD 979
Query: 1504 WGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHR 1563
WG+H I R +DGS R +IV + +PNGLT+DY R+YW DA +D I+ + L+G +R
Sbjct: 980 WGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNR 1039
Query: 1564 -VQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAVSA 1622
V L D + F +T F+DY+YWTDW KSI RA K TG N TL+ + L M++ A
Sbjct: 1040 HVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHA 1099
Query: 1623 DRQHGW--NPCKESNGGCSHLCLFR-GHEYICACP 1654
RQ +PCK +NGGCS+LCL G + CACP
Sbjct: 1100 LRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACP 1134
Score = 246 bits (602), Expect = 6e-64
Identities = 130/331 (39%), Positives = 194/331 (58%), Gaps = 13/331 (3%)
Query: 1026 CSHLCLLKPGGRSCACPIGIK-LNKDGKTC--ADGPINYLIFAHRVDIRVISLDVPYLID 1082
CS C+ G C C G D +C +LIFA+R +R ++LD +
Sbjct: 808 CSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGS---N 864
Query: 1083 VVLPLPPLKNALGVDVDHSTGLIYWTD-TGQRKIQRATRL-GTHVETVIGNGLHTADGIV 1140
L L NA+ +D D+ +IYWTD T Q + R L G++V+ + GL DG+
Sbjct: 865 YTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLA 924
Query: 1141 IDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSA 1200
+D G +YW D GR++IEV++L+G R VLV +GL PRA+ + + GY++W+DWG +
Sbjct: 925 VDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHS 984
Query: 1201 KIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLS 1260
I R MDG++R VIVD KI WPNGL +D + R+YW DA+ IE + DG +R VLS
Sbjct: 985 LIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLS 1044
Query: 1261 -NVPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDI---RAIQSER 1316
++P+ + + + ++YWTDW+TK+++RA KT ++ ++ L MD+ A++
Sbjct: 1045 QDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPD 1104
Query: 1317 VLENACGTDNGGCSHLCLRSP-LGYTCACPT 1346
V + C +NGGCS+LCL SP G+ CACPT
Sbjct: 1105 VPNHPCKVNNGGCSNLCLLSPGGGHKCACPT 1135
Score = 235 bits (576), Expect = 8e-61
Identities = 128/320 (40%), Positives = 176/320 (55%), Gaps = 34/320 (10%)
Query: 763 DIHSRSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNS 822
D HS E L++A R LR K +D + + + + +AVALD+D +
Sbjct: 833 DPHSCKAVTDEEPFLIFANRYYLR------KLNLDGSNYTLLKQGLNNAVALDFDYREQM 886
Query: 823 IFWTDV--EKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSK 880
I+WTDV + I R +LNGS+ + + L P GLA DW+ +YW D G + IEVSK
Sbjct: 887 IYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSK 946
Query: 881 SDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTW 940
+G+ RT+L + +PR +VV+ + G +YW+DWG I R MDG +R ++ ++TW
Sbjct: 947 LNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITW 1006
Query: 941 PNGLALDLVHNRIYWTDGGNKTIEYANLDGTGR-TKLIENLPHPFGLDLYGDEVFWTDWD 999
PNGL LD V RIYW D IE+A+LDG+ R L +++PH F L L+ D V+WTDW+
Sbjct: 1007 PNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWE 1066
Query: 1000 TQSIQAANKDTGAKRRTL------------------------GCGKNNGGCSHLCLLKP- 1034
T+SI A+K TG + L C NNGGCS+LCLL P
Sbjct: 1067 TKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPG 1126
Query: 1035 GGRSCACPIGIKLNKDGKTC 1054
GG CACP L DG+TC
Sbjct: 1127 GGHKCACPTNFYLGSDGRTC 1146
Score = 206 bits (504), Expect = 4e-52
Identities = 152/492 (30%), Positives = 222/492 (45%), Gaps = 38/492 (7%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKC-NDGKCIPERW 321
C+E FEC+N +C+ K + CDG +DCGD +DE + +C F C C+PERW
Sbjct: 550 CSEAQFECQNHRCISKQWLCDGSDDCGDGSDE-AAHCEGKTCGPSSFSCPGTHVCVPERW 608
Query: 322 RCDNERDCADGGDE---LNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEM 378
CD ++DCADG DE C NS C E+ C +R+C+ K ++CD RDC +G DE
Sbjct: 609 LCDGDKDCADGADESIAAGCLYNS--TCDDREFMCQNRQCIPKHFVCDHDRDCADGSDE- 665
Query: 379 NCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKC-SAEE 437
S E + TC P E +N R +R+ CDG DC D + P C S E
Sbjct: 666 ----SPECEYPTCGPSEFRCANG-RCLSSRQWECDGENDC--HDQSDEAPKNPHCTSPEH 718
Query: 438 KC----EKLCITTYDGHAACACPMGFLLAE--DKYSCRDIDECMYEQDPVCSQTCSNTVG 491
KC + LC + A C + D+ C I+EC+ + CSQ C +
Sbjct: 719 KCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCH-INECLSRKLSGCSQDCEDLKI 777
Query: 492 SFRCGCMTGYILRPDERSCKPTGE-SPTLLFSNR-IGIRQVW--LTGDNYMSVVKGLHNA 547
F+C C G+ L+ D R+C E S T S R I + L + Y H+
Sbjct: 778 GFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTHGSYKCLCVEGYAPRGGDPHSC 837
Query: 548 VALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDS 607
A+ E L+F + LR + + N +++ GL + D+ +++WTD
Sbjct: 838 KAVT-DEEPFLIFANRYYLRKLNLDGSN----YTLLKQGLNNAVALDFDYREQMIYWTDV 892
Query: 608 GTR--RVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDK 665
T+ + L+GS VL L P +AV ++W D G IE + ++G
Sbjct: 893 TTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKG-RDTIEVSKLNGAY 951
Query: 666 RKTVIYDEIFWPNGLTIDYTESKIYWAD-AKHHVIERAAFDGRDRRKVTTKGLPHPFALT 724
R ++ + P L +D +YW D H +I R DG R + + P LT
Sbjct: 952 RTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLT 1011
Query: 725 L--FDDAIYWTD 734
L + IYW D
Sbjct: 1012 LDYVTERIYWAD 1023
Score = 173 bits (422), Expect = 4e-42
Identities = 99/297 (33%), Positives = 142/297 (47%), Gaps = 34/297 (11%)
Query: 169 STNVCIALEWLCDGDNDCGDFSDEINCDV----------VKTSLLVPS---ANASLNIGD 215
ST +C ++CDGDNDC D SDE NCD+ T+ +P N N GD
Sbjct: 1198 STGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGD 1257
Query: 216 VITN---PTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVEL--MRCAEIDFEC 270
P V A + I D + ++P M C +F C
Sbjct: 1258 GEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRC 1317
Query: 271 KNT-KCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDC 329
K++ +C+P ++CDG++DCGD +DE +C +F+C + +C+P RW+CD + DC
Sbjct: 1318 KDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDC 1377
Query: 330 ADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQY 389
D DE +C P R CS E++CA+ RC+ W CDG DC +G DE +C C+ DQ+
Sbjct: 1378 GDNSDEESCTP---RPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQF 1434
Query: 390 TCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPL-KRKCSAEE-KCEK-LC 443
C+ +C+ + CD DC G DEE C R C +E +C LC
Sbjct: 1435 QCKS---------GHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLC 1482
Score = 164 bits (399), Expect = 2e-39
Identities = 108/352 (30%), Positives = 166/352 (47%), Gaps = 33/352 (9%)
Query: 1327 GGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEF--LIFATRGSITYISLE 1384
G CS LC + G+ C+C F K T CK+ E+ L A I +
Sbjct: 1647 GTCSQLCNNTKGGHLCSCARN--FMK-----THNTCKAEGSEYQVLYIADDNEIRSLFPG 1699
Query: 1385 SPEQ-WDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVI--RSINM----TNMSESKTI 1437
P ++ E A+D H +++T+ I RS+ T + +
Sbjct: 1700 HPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQ 1759
Query: 1438 ISQK--------LETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITGLT-EPR 1488
I + L+ P G+ +DW+A N+YWTD+ VIEVA++ G +RK LI+G+ EP
Sbjct: 1760 IDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPH 1819
Query: 1489 ALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDA 1548
A+ + P +G +YWSDWG HP IE + +DG+ R+ +VQ ++ +P GL +DY RLYW DA
Sbjct: 1820 AIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADA 1879
Query: 1549 LKDRIDTSDLNGQHRVQLVPDAK----NPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNI 1604
I + LNG + + D+K +PF + F+DYIY + + + K +
Sbjct: 1880 KLSVIGSIRLNGTDPI-VAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPL 1938
Query: 1605 TLIRTNLEMAMEIKAVSADRQ-HGWNPCKESNGGCSHLCLFRGHEYICACPD 1655
+ L A ++ +Q NPC C LCL +C CP+
Sbjct: 1939 VNLTGGLSHASDVVLYHQHKQPEVTNPCDRKK--CEWLCLLSPSGPVCTCPN 1988
Score = 159 bits (385), Expect = 1e-37
Identities = 112/360 (31%), Positives = 153/360 (42%), Gaps = 29/360 (8%)
Query: 1024 GGCSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGP-INYLIFAHRVDIRVISLDVPY-L 1080
G CS LC GG C+C K TC A+G L A +IR + P+
Sbjct: 1647 GTCSQLCNNTKGGHLCSCARNFM--KTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSA 1704
Query: 1081 IDVVLPLPPLKNALGVDVDHSTGLIYWTD------------------TGQRKIQRATRLG 1122
+ +DV G +YWT+ T R ++ R
Sbjct: 1705 YEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGV 1764
Query: 1123 THVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAI 1182
TH+ +GL GI ID +YWTD GR+ IEVA++ G NRK L+ +D P AI
Sbjct: 1765 THLNI---SGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAI 1821
Query: 1183 ALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKI 1242
+ G M+WSDWG KIE A MDG R +V + I+WP GLA+D RLYW DAK+
Sbjct: 1822 VVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKL 1881
Query: 1243 LTIESSDFDGHDRRTVLSN---VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVI 1299
I S +G D + + +P+ I + +IY + + + K S + +
Sbjct: 1882 SVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNL 1941
Query: 1300 RKNLEGLMDIRAIQSERVLENACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTP 1359
L D+ + E D C LCL SP G C CP G + T P
Sbjct: 1942 TGGLSHASDVVLYHQHKQPEVTNPCDRKKCEWLCLLSPSGPVCTCPNGKRLDNGTCVPVP 2001
Score = 144 bits (348), Expect = 3e-33
Identities = 82/253 (32%), Positives = 141/253 (55%), Gaps = 14/253 (5%)
Query: 1413 IFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARL 1472
IF++D+ I+ IN + S TI+ + + + GL + +YWT I +
Sbjct: 71 IFFSDIHFGNIQQIN-DDGSRRITIV-ENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTV 128
Query: 1473 DGS-----SRKVLIT--GLTEPRALALFPAKGYLYWSDWGE-HPYIERSYLDGSQRQIIV 1524
D + R+ +IT G PRA L + ++W++W E HP I R+ L G+ ++
Sbjct: 129 DQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLI 188
Query: 1525 QVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHR-VQLVPDAKNPFGMTQFKDYI 1583
+ D+ PNGL ID++ +LY++DA D+I+ + +G HR V L + +PFG+ + ++I
Sbjct: 189 EKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHI 248
Query: 1584 YWTDWYKKSIIRADKRTGKNITLIRTNL-EMAMEIKAVSADRQH-GWNPCKESNGGCSHL 1641
+WTDW ++++ RA+K G N+ L+R ++ + M I AV+ D +PC+ +NGGC L
Sbjct: 249 FWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDL 308
Query: 1642 CLFRGHEYI-CAC 1653
CL ++ C+C
Sbjct: 309 CLLTHQGHVNCSC 321
Score = 137 bits (332), Expect = 3e-31
Identities = 100/336 (29%), Positives = 145/336 (43%), Gaps = 42/336 (12%)
Query: 762 MDIHSRSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSN 821
M H+ E E +LY D ++ L P + + + A+D K+
Sbjct: 1669 MKTHNTCKAEGSEYQVLYIA-DDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHVKAG 1727
Query: 822 SIFWTDVEKDTINRAYL--------NGSHQ-------TTIVDSNLIWPAGLAFDWITDKI 866
++WT+ TI+ L + H+ T + S L P G+A DW+ +
Sbjct: 1728 RVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNV 1787
Query: 867 YWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMD 926
YWTD G + IEV++ G R L ID+P IVV+P G MYWSDWG P IE A MD
Sbjct: 1788 YWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMD 1847
Query: 927 GGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN---LPHP 983
G R+ L+ + WP GLA+D + R+YW D I L+GT ++ L HP
Sbjct: 1848 GTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHP 1907
Query: 984 FGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTLGCGKNNGG------------------ 1025
F +D++ D ++ + + +K + L G ++
Sbjct: 1908 FSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVTNPCD 1967
Query: 1026 ---CSHLCLLKPGGRSCACPIGIKLNKDGKTCADGP 1058
C LCLL P G C CP G +L D TC P
Sbjct: 1968 RKKCEWLCLLSPSGPVCTCPNGKRL--DNGTCVPVP 2001
Score = 136 bits (330), Expect = 5e-31
Identities = 90/261 (34%), Positives = 122/261 (46%), Gaps = 33/261 (12%)
Query: 169 STNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTK 228
S C++ C+G +DCGD SDEI C+ KT+ V G I N +
Sbjct: 390 SNGRCVSNMLWCNGADDCGDGSDEIPCN--KTACGVGEFRC--RDGTCIGNSS------- 438
Query: 229 PTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFE-CKNTK-CVPKDFQCDGDN 286
R F + + N +T + + F+ C+ T C + CDG N
Sbjct: 439 -----RCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGAN 493
Query: 287 DCGDWTDEDSCPMVPGS-CNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRN 345
DCGD++DE CP V C F C G+CIP W CD E DC G DE +C +
Sbjct: 494 DCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCN----KF 549
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDE-MNCE-VSCEEDQYTCRPQEHLMSNAFR 403
CS ++ C + RC+ K WLCDG DC +G DE +CE +C ++C P H+
Sbjct: 550 CSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSC-PGTHV------ 602
Query: 404 NCVNRKHVCDGMKDCPRGDDE 424
CV + +CDG KDC G DE
Sbjct: 603 -CVPERWLCDGDKDCADGADE 622
Score = 133 bits (321), Expect = 6e-30
Identities = 95/331 (28%), Positives = 163/331 (49%), Gaps = 25/331 (7%)
Query: 1061 YLIFAHRVDIRVISL-DVPYLIDVVLPLPP---LKNALGVDVDHSTGL-------IYWTD 1109
YL+++ R ++ I L D L V P +KN + + D+ G I+++D
Sbjct: 16 YLLYSERTILKSIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSD 75
Query: 1110 TGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDG---- 1165
IQ+ G+ T++ N + + +G+ +YWT ++I +D
Sbjct: 76 IHFGNIQQINDDGSRRITIVEN-VGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPG 134
Query: 1166 --RNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTS-AKIERADMDGNNRRVIVDNKIKW 1222
V+ +G D PRA L MFW++W I RA + G N +++ I+
Sbjct: 135 AFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRT 194
Query: 1223 PNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLSNVP-YPYGIVIVGQHIYWTDWK 1281
PNGLAID +LY++DA + IE ++DG R +L + P +P+G+ + G+HI+WTDW
Sbjct: 195 PNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWV 254
Query: 1282 TKALHRADKTNASDPIVIRKNL-EGLMDIRAIQSE-RVLE-NACGTDNGGCSHLCLRSPL 1338
+A+ RA+K S+ ++R ++ + M I A+ ++ E + C +NGGC LCL +
Sbjct: 255 RRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLTHQ 314
Query: 1339 GY-TCACPTGMPFEKSTTDQ-TPKKCKSHPE 1367
G+ C+C G + T + C++ E
Sbjct: 315 GHVNCSCRGGRILQDDLTCRAVNSSCRAQDE 345
Score = 129 bits (311), Expect = 1e-28
Identities = 97/319 (30%), Positives = 156/319 (48%), Gaps = 43/319 (13%)
Query: 777 LLYARRKDLRLKQLESKKPIDS-LDMVIPVETIKSAVALDWDQKS-------NSIFWTDV 828
LLY+ R L+ L ++ +++ + E +K+ +AL +D ++ N IF++D+
Sbjct: 17 LLYSERTILKSIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDI 76
Query: 829 EKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSM--- 885
I + +GS + TIV+ N+ GLA+ D +YWT T+ I D +
Sbjct: 77 HFGNIQQINDDGSRRITIVE-NVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGA 135
Query: 886 ---RTLLAWDHIDKPRDIVVNPEGGVMYWSDWGAS-PCIERADMDGGNRKKLIFGQMTWP 941
T++ D PR V++ +M+W++W P I RA + G N LI + P
Sbjct: 136 FERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTP 195
Query: 942 NGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIENLP-HPFGLDLYGDEVFWTDWDT 1000
NGLA+D ++Y++D IE DG+ R ++++ P HPFGL +YG+ +FWTDW
Sbjct: 196 NGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVR 255
Query: 1001 QSIQAANKDTGAKRRTL------------------------GCGKNNGGCSHLCLLKPGG 1036
+++Q ANK G+ + L C NNGGC LCLL G
Sbjct: 256 RAVQRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLTHQG 315
Query: 1037 R-SCACPIGIKLNKDGKTC 1054
+C+C G ++ +D TC
Sbjct: 316 HVNCSCR-GGRILQDDLTC 333
Score = 125 bits (301), Expect = 2e-27
Identities = 64/182 (35%), Positives = 94/182 (51%), Gaps = 17/182 (9%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDE-DSCPMVPGSCNAGEFKCNDGKCIPERW 321
C F CKN KC+P ++CD ++DCGD +DE CP C G+F+C+ G C +
Sbjct: 1150 CTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEF--KCRPGQFQCSTGICTNPAF 1207
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNC 380
CD + DC D DE NC I C ++ C + RC+ + C+G +C +GEDE +C
Sbjct: 1208 ICDGDNDCQDNSDEANC---DIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDC 1264
Query: 381 -EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE-K 438
EV+C +Q+ C + + C+ R VCD DC G DE + C +E +
Sbjct: 1265 PEVTCAPNQFQC--------SITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFR 1316
Query: 439 CE 440
C+
Sbjct: 1317 CK 1318
Score = 124 bits (298), Expect = 4e-27
Identities = 88/281 (31%), Positives = 120/281 (42%), Gaps = 43/281 (15%)
Query: 173 CIALEWLCDGDNDCGDFSDE-INCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTV 231
CI W CD ++DCGD SDE +C K + G + TNP +
Sbjct: 1162 CIPFWWKCDTEDDCGDHSDEPPDCPEFKCR----PGQFQCSTG-ICTNPAFICDGDNDCQ 1216
Query: 232 VIRYESFC-AKKALDNAANPRSTWNQPVELMRC--------AEIDFECKNTKCVPKDFQ- 281
E+ C L + +T + RC E + +C C P FQ
Sbjct: 1217 DNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQC 1276
Query: 282 ------------CDGDNDCGDWTDED-SCPMVPGSCNAGEFKCND-GKCIPERWRCDNER 327
CD DNDC D +DE +C + +C EF+C D G+CIP RW+CD E
Sbjct: 1277 SITKRCIPRVWVCDRDNDCVDGSDEPANCTQM--TCGVDEFRCKDSGRCIPARWKCDGED 1334
Query: 328 DCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV-SCEE 386
DC DG DE + + R C ++ C + RCV W CD DC + DE +C C E
Sbjct: 1335 DCGDGSDEPKEECDE-RTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSE 1393
Query: 387 DQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC 427
+++C A C+ + CDG DC G DE+ C
Sbjct: 1394 SEFSC---------ANGRCIAGRWKCDGDHDCADGSDEKDC 1425
Score = 123 bits (297), Expect = 5e-27
Identities = 82/271 (30%), Positives = 122/271 (45%), Gaps = 26/271 (9%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALT-KPTV 231
CI C+ DC D SDE+NC S + L + V+ P +L P+
Sbjct: 433 CIGNSSRCNQFVDCEDASDEMNCSATDCS-----SYFRLGVKGVLFQPCERTSLCYAPSW 487
Query: 232 VIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDW 291
V + C + D P V+ RC F C + +C+P + CD ++DC
Sbjct: 488 VCDGANDCGDYS-DERDCPG------VKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHG 540
Query: 292 TDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDE-LNCKPNSIRNCSLDE 350
DE C C+ +F+C + +CI ++W CD DC DG DE +C+ + C
Sbjct: 541 EDETHCNKF---CSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEG---KTCGPSS 594
Query: 351 YTCADRR-CVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRK 409
++C CV + WLCDG +DC +G DE + C + TC +E + N R C+ +
Sbjct: 595 FSCPGTHVCVPERWLCDGDKDCADGADE-SIAAGCLYNS-TCDDREFMCQN--RQCIPKH 650
Query: 410 HVCDGMKDCPRGDDEE-RCPLKRKCSAEEKC 439
VCD +DC G DE C +E +C
Sbjct: 651 FVCDHDRDCADGSDESPECEYPTCGPSEFRC 681
Score = 118 bits (283), Expect = 3e-25
Identities = 64/183 (34%), Positives = 95/183 (51%), Gaps = 22/183 (12%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKC-NDGKCIPER 320
+C F+C C F CDGDNDC D +DE +C + C +FKC N +CIP
Sbjct: 1189 KCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDI--HVCLPSQFKCTNTNRCIPGI 1246
Query: 321 WRCDNERDCADGGDELNCKPNSIRNCSLDEYTCA-DRRCVLKTWLCDGVRDCTNGEDE-M 378
+RC+ + +C DG DE +C P C+ +++ C+ +RC+ + W+CD DC +G DE
Sbjct: 1247 FRCNGQDNCGDGEDERDC-PEV--TCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPA 1303
Query: 379 NC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE 437
NC +++C D++ C+ C+ + CDG DC G DE K +C E
Sbjct: 1304 NCTQMTCGVDEFRCKDS--------GRCIPARWKCDGEDDCGDGSDEP----KEECD-ER 1350
Query: 438 KCE 440
CE
Sbjct: 1351 TCE 1353
Score = 105 bits (253), Expect = 1e-21
Identities = 60/187 (32%), Positives = 94/187 (50%), Gaps = 13/187 (6%)
Query: 600 DLLFWTDSGTRRVEVATLDGSK------RAVLVANDLDKPRAIAVHPGDALVFWTDWGP- 652
D L+WT T + T+D ++ V+ + D PRA + L+FWT+W
Sbjct: 111 DTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQ 170
Query: 653 NPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKV 712
+P I RA + G T+I +I PNGL ID+ K+Y++DA IER +DG R +
Sbjct: 171 HPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVI 230
Query: 713 TTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGL-NVPMDI-----HS 766
HPF L ++ + I+WTDW +++ NK+ G ++ + + PM I +
Sbjct: 231 LKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVANDT 290
Query: 767 RSCEETP 773
SCE +P
Sbjct: 291 NSCELSP 297
Score = 104 bits (250), Expect = 3e-21
Identities = 68/236 (28%), Positives = 99/236 (41%), Gaps = 24/236 (10%)
Query: 264 AEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRC 323
A+ +FEC N +C+ CDG C D +DE C +C++G+C+ C
Sbjct: 342 AQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWC 401
Query: 324 DNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVS 383
+ DC DG DE+ C + C + E+ C D C+ + C+ DC + DEMNC +
Sbjct: 402 NGADDCGDGSDEIPCNKTA---CGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSAT 458
Query: 384 CEEDQYTCRPQEHLMSNAFRN--CVNRKHVCDGMKDCPRGDDEERCP-LKRKCSAEEKCE 440
+ + L R C VCDG DC DE CP +KR
Sbjct: 459 DCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKR--------- 509
Query: 441 KLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV-CSQTCSNTVGSFRC 495
C Y ACP G + ++C D+C + +D C++ CS F C
Sbjct: 510 PRCPLNY-----FACPSGRCIPM-SWTCDKEDDCEHGEDETHCNKFCSE--AQFEC 557
Score = 104 bits (249), Expect = 3e-21
Identities = 65/196 (33%), Positives = 91/196 (46%), Gaps = 24/196 (12%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
RC + +C N +CV C+G +DCGD +DE C +C GEF+C DG CI
Sbjct: 381 RCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKT--ACGVGEFRCRDGTCIGNSS 438
Query: 322 RCDNERDCADGGDELNCKPNSIRNCS----------LDEYTCADRRCVLKTWLCDGVRDC 371
RC+ DC D DE+NC S +CS L + C +W+CDG DC
Sbjct: 439 RCNQFVDCEDASDEMNC---SATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDC 495
Query: 372 TNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKR 431
+ DE +C + C P + + R C+ CD DC G+DE C +
Sbjct: 496 GDYSDERDCP---GVKRPRC-PLNYFACPSGR-CIPMSWTCDKEDDCEHGEDETHC--NK 548
Query: 432 KCS-AEEKCEK-LCIT 445
CS A+ +C+ CI+
Sbjct: 549 FCSEAQFECQNHRCIS 564
Score = 93.5 bits (222), Expect = 6e-18
Identities = 77/288 (26%), Positives = 126/288 (43%), Gaps = 16/288 (5%)
Query: 1025 GCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPY---LI 1081
GCS C G C C G +L DG+TCAD ++ R I+ Y +
Sbjct: 767 GCSQDCEDLKIGFKCRCRPGFRLKDDGRTCAD--VDECSTTFPCSQRCINTHGSYKCLCV 824
Query: 1082 DVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVI 1141
+ P ++ D LI+ R R L T++ GL+ A +
Sbjct: 825 EGYAPRGGDPHSCKAVTDEEPFLIF----ANRYYLRKLNLDGSNYTLLKQGLNNAVALDF 880
Query: 1142 DSTGRKIYWTD--GGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTS 1199
D + IYWTD + I L+G N +VL TGL +P +A+ + G ++W D G
Sbjct: 881 DYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRD 940
Query: 1200 AKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFDGHDRRTV 1258
IE + ++G R V+V + ++ P L +D G LYW D I DG R +
Sbjct: 941 T-IEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVI 999
Query: 1259 L-SNVPYPYGIVI--VGQHIYWTDWKTKALHRADKTNASDPIVIRKNL 1303
+ + + +P G+ + V + IYW D + + A ++ +V+ +++
Sbjct: 1000 VDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDI 1047
Score = 92.7 bits (220), Expect = 1e-17
Identities = 54/188 (28%), Positives = 83/188 (44%), Gaps = 27/188 (14%)
Query: 303 SCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKT 362
+C A +F C + KCIP W+CD E DC D DE P C ++ C+ C
Sbjct: 1149 NCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEF--KCRPGQFQCSTGICTNPA 1206
Query: 363 WLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGD 422
++CDG DC + DE NC++ + C P + +N R C+ C+G +C G+
Sbjct: 1207 FICDGDNDCQDNSDEANCDI------HVCLPSQFKCTNTNR-CIPGIFRCNGQDNCGDGE 1259
Query: 423 DEERC------PLKRKCSAEEKC---------EKLCITTYDGHAACACPMGFLLAEDKYS 467
DE C P + +CS ++C + C+ D A C D++
Sbjct: 1260 DERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCT---QMTCGVDEFR 1316
Query: 468 CRDIDECM 475
C+D C+
Sbjct: 1317 CKDSGRCI 1324
Score = 83.4 bits (197), Expect = 7e-15
Identities = 70/266 (26%), Positives = 122/266 (45%), Gaps = 18/266 (6%)
Query: 685 TESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLF--DDAIYWTDWHTKS--I 740
T+ + + A + + + DG + + +GL + AL + IYWTD T+ I
Sbjct: 841 TDEEPFLIFANRYYLRKLNLDGSNYT-LLKQGLNNAVALDFDYREQMIYWTDVTTQGSMI 899
Query: 741 STVNKNTGMGIQTVH-AGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESKKPIDSL 799
++ N G +Q +H GL+ P + + + L + +D +E K +
Sbjct: 900 RRMHLN-GSNVQVLHRTGLSNPDGL---AVDWVGGNLYWCDKGRDT----IEVSKLNGAY 951
Query: 800 DMVIPVETIKSAVALDWDQKSNSIFWTDV-EKDTINRAYLNGSHQTTIVDSNLIWPAGLA 858
V+ ++ AL D ++ ++WTD + I R ++GS ++ IVD+ + WP GL
Sbjct: 952 RTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLT 1011
Query: 859 FDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASP 918
D++T++IYW D + IE + DGS R ++ I P + +YW+DW +
Sbjct: 1012 LDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDI--PHIFALTLFEDYVYWTDW-ETK 1068
Query: 919 CIERADMDGGNRKKLIFGQMTWPNGL 944
I RA G K L+ + P L
Sbjct: 1069 SINRAHKTTGTNKTLLISTLHRPMDL 1094
Score = 78.6 bits (185), Expect = 2e-13
Identities = 72/271 (26%), Positives = 104/271 (38%), Gaps = 28/271 (10%)
Query: 107 EGTEDDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTI 166
E ED+ C C + F CQ + CI + +
Sbjct: 538 EHGEDETHCNKFCSEAQFECQ-NHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFS 596
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIAL 226
C T+VC+ WLCDGD DC D +DE + L N++ + + + I
Sbjct: 597 CPGTHVCVPERWLCDGDKDCADGADE---SIAAGCLY----NSTCDDREFMCQNRQCI-- 647
Query: 227 TKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCV-PKDFQCDGD 285
V ++ CA + D + P E RCA N +C+ + ++CDG+
Sbjct: 648 -PKHFVCDHDRDCADGS-DESPECEYPTCGPSE-FRCA-------NGRCLSSRQWECDGE 697
Query: 286 NDCGDWTDE----DSCPMVPGSCNA-GEFKCNDGKCIPERWRCDNERDCADGGDELNCKP 340
NDC D +DE C CNA +F C+ G+C+ E C+ + DC D DE C
Sbjct: 698 NDCHDQSDEAPKNPHCTSPEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHI 757
Query: 341 NSI--RNCSLDEYTCADRRCVLKTWLCDGVR 369
N R S C D + K G R
Sbjct: 758 NECLSRKLSGCSQDCEDLKIGFKCRCRPGFR 788
Score = 70.9 bits (166), Expect = 4e-11
Identities = 75/267 (28%), Positives = 108/267 (40%), Gaps = 35/267 (13%)
Query: 102 DGPLNEGTEDDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEH 161
D + +++++ PC + FSC + CI + CD
Sbjct: 1374 DNDCGDNSDEESCTPRPCSESEFSCA-NGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMD 1432
Query: 162 ENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDV-VKTSLLVPSANASLNIGDVITNP 220
+ + C S + CI L W CD D DC D SDE C V+T L + N
Sbjct: 1433 QFQ--CKSGH-CIPLRWRCDADADCMDGSDEEACGTGVRTCPL----------DEFQCNN 1479
Query: 221 TVLIALTKPTV-VIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTK-CVPK 278
T L KP E C + +N P RC KN + C+
Sbjct: 1480 T----LCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRC-------KNDRVCLWI 1528
Query: 279 DFQCDGDNDCGDWTDEDSC-PMVPGS--C-NAGEFKCNDGKCIPERWRCDNERDCADGGD 334
QCDG ++CGD TDE+ C P + C + EF C + +C+ RC+ DC DG D
Sbjct: 1529 GRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCL-SSLRCNMFDDCGDGSD 1587
Query: 335 ELNCKPN-SIRNCSLDEYTCADR-RCV 359
E +C + + +C+ + C D RCV
Sbjct: 1588 EEDCSIDPKLTSCATNASICGDEARCV 1614
Score = 60.9 bits (141), Expect = 4e-08
Identities = 61/229 (26%), Positives = 95/229 (41%), Gaps = 16/229 (6%)
Query: 680 LTIDYTESKIYWADA--KHHVIERAAFDGRDRRKVTTKGLPHPFALTL--FDDAIYWTDW 735
L DY E IYW D + +I R +G + + + GL +P L + +YW D
Sbjct: 878 LDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDK 937
Query: 736 HTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESKKP 795
+I N V +GL P R+ + LY D L +
Sbjct: 938 GRDTIEVSKLNGAYRTVLVSSGLREP-----RALVVDVQNGYLYWT--DWGDHSLIGRIG 990
Query: 796 IDSLDMVIPVET-IKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWP 854
+D + V+T I L D + I+W D +D I A L+GS++ ++ ++ P
Sbjct: 991 MDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDI--P 1048
Query: 855 AGLAFDWITDKIYWTDGGTNRI-EVSKSDGSMRTLLAWDHIDKPRDIVV 902
A D +YWTD T I K+ G+ +TLL + +P D+ V
Sbjct: 1049 HIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLI-STLHRPMDLHV 1096
Score = 59.3 bits (137), Expect = 1e-07
Identities = 29/97 (29%), Positives = 43/97 (44%), Gaps = 7/97 (7%)
Query: 343 IRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAF 402
+ NC+ ++ C + +C+ W CD DC + DE C E + CRP + S
Sbjct: 1147 VSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDE---PPDCPE--FKCRPGQFQCSTGI 1201
Query: 403 RNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKC 439
C N +CDG DC DE C + ++ KC
Sbjct: 1202 --CTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKC 1236
Score = 54.0 bits (124), Expect = 5e-06
Identities = 28/90 (31%), Positives = 54/90 (60%), Gaps = 3/90 (3%)
Query: 561 WSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGS 620
W+E + ++R A ++ N+ +I + TP G+A+D + L+++D+ ++E DGS
Sbjct: 167 WNEQHPSIMRAA-LSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGS 225
Query: 621 KRAVLVANDLDKPRAIAVHPGDALVFWTDW 650
R V++ ++ P +AV+ G+ +FWTDW
Sbjct: 226 HRYVILKSEPVHPFGLAVY-GEH-IFWTDW 253
Score = 51.6 bits (118), Expect = 2e-05
Identities = 19/33 (57%), Positives = 24/33 (72%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCDVVK 199
C T++C A W+CDG NDCGD+SDE +C VK
Sbjct: 476 CERTSLCYAPSWVCDGANDCGDYSDERDCPGVK 508
Score = 49.6 bits (113), Expect = 1e-04
Identities = 44/157 (28%), Positives = 64/157 (40%), Gaps = 16/157 (10%)
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGG---DELNCKPNSIRNCSLD 349
D +SC + P N G C D + + + C G D+L C+ + + D
Sbjct: 289 DTNSCELSPCRINNGG--CQDLCLLTHQGHVNCS--CRGGRILQDDLTCRAVNSSCRAQD 344
Query: 350 EYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRK 409
E+ CA+ C+ + CDGV C + DE + C+ SN CV+
Sbjct: 345 EFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRR----CKKTFRQCSNG--RCVSNM 398
Query: 410 HVCDGMKDCPRGDDEERCPLKRKCSAEE-KC-EKLCI 444
C+G DC G DE C K C E +C + CI
Sbjct: 399 LWCNGADDCGDGSDEIPCN-KTACGVGEFRCRDGTCI 434
Score = 44.8 bits (101), Expect = 0.003
Identities = 33/94 (35%), Positives = 38/94 (40%), Gaps = 9/94 (9%)
Query: 107 EGTEDDAGC-ITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDE---HE 162
+ D+A C I CL F C + CIP R R C E
Sbjct: 1216 QDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDE----RDCPEVTCAP 1271
Query: 163 NRTICHSTNVCIALEWLCDGDNDCGDFSDE-INC 195
N+ C T CI W+CD DNDC D SDE NC
Sbjct: 1272 NQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANC 1305
Score = 42.3 bits (95), Expect = 0.015
Identities = 27/86 (31%), Positives = 33/86 (38%), Gaps = 5/86 (5%)
Query: 110 EDDAGCI-TPCLKINFSCQISCTCIPMEK--RXXXXXXXXXXXXXXXXXRSCDEHENRTI 166
ED+ C C F C I+ CIP +C E R
Sbjct: 1259 EDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFR-- 1316
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDE 192
C + CI W CDG++DCGD SDE
Sbjct: 1317 CKDSGRCIPARWKCDGEDDCGDGSDE 1342
Score = 39.1 bits (87), Expect = 0.14
Identities = 40/188 (21%), Positives = 82/188 (43%), Gaps = 11/188 (5%)
Query: 556 KKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVA 615
K + E NL + ++M +VI + AG + + +F++D ++
Sbjct: 26 KSIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPG-TPNRIFFSDIHFGNIQQI 84
Query: 616 TLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNP----KIERADMDGDKRKTVI- 670
DGS+R +V N + +A H G ++WT + + +++ +R+TVI
Sbjct: 85 NDDGSRRITIVEN-VGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVIT 143
Query: 671 YDEIFWPNGLTIDYTESKIYWA--DAKHHVIERAAFDGRDRRKVTTKGL--PHPFALTLF 726
P +D ++ ++W + +H I RAA G + + K + P+ A+
Sbjct: 144 MSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHR 203
Query: 727 DDAIYWTD 734
+ +Y++D
Sbjct: 204 AEKLYFSD 211
Score = 38.3 bits (85), Expect = 0.25
Identities = 18/58 (31%), Positives = 28/58 (48%), Gaps = 1/58 (1%)
Query: 422 DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQD 479
+D C L C+ LC+ T+ GH C+C G +L +D +CR ++ QD
Sbjct: 288 NDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRIL-QDDLTCRAVNSSCRAQD 344
Score = 33.1 bits (72), Expect = 9.3
Identities = 38/152 (25%), Positives = 61/152 (40%), Gaps = 23/152 (15%)
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCT-NGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRN 404
C ++ C D C+L G +C+ G + +++C +CR Q+ A
Sbjct: 298 CRINNGGCQDL-CLLTH---QGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFEC-ANGE 352
Query: 405 CVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAED 464
C+N CDG+ C DE+ C++ +C+K +G C L
Sbjct: 353 CINFSLTCDGVPHCKDKSDEK----PSYCNSR-RCKKTFRQCSNGR----CVSNMLW--- 400
Query: 465 KYSCRDIDECMYEQDPV-CSQTCSNTVGSFRC 495
C D+C D + C++T VG FRC
Sbjct: 401 ---CNGADDCGDGSDEIPCNKTACG-VGEFRC 428
>AK054663-1|BAB70786.1| 820|Homo sapiens umor (LRPDIT) mRNA.
protein.
Length = 820
Score = 391 bits (963), Expect = e-107
Identities = 224/643 (34%), Positives = 325/643 (50%), Gaps = 49/643 (7%)
Query: 158 CDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEI-----NCDVVKTSL----LVPSAN 208
CD E +CH C++ WLCDGD DC D SDE C V + S +P A
Sbjct: 70 CDPGE--FLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTSRTCQVDQFSCGNGRCIPRAW 127
Query: 209 ASLNIGDVITNPTVLIALTKPTVVIRYESFC-------AKKALDNAANPRSTWNQPVELM 261
D + + PT + C +K D+ + ++ +
Sbjct: 128 LCDREDDCGDQTDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVH 187
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDED--SCPMV----PGSCNAGEFKCN-DG 314
C + F C + +C+P + CDGDNDCGD++DE +C P CN EF+C+ DG
Sbjct: 188 SCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDG 247
Query: 315 KCIPERWRCDNERDCADGGDELNCKPNSIRNCS-LDEYTC-ADRRCVLKTWLCDGVRDCT 372
C+P+ WRCD E+DC DG DE C +IR+C +++C + RC+ K W+CDG DC
Sbjct: 248 NCVPDLWRCDGEKDCEDGSDEKGCN-GTIRSCDHKTKFSCWSTGRCINKAWVCDGDIDCE 306
Query: 373 NGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRK 432
+ DE +C D + C P +H +N C+ + +C+G KDCP G DE L +
Sbjct: 307 DQSDEDDC------DSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGY--LCDE 358
Query: 433 CSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVG 491
CS C C C+CP G L +D +C +D C CSQ C
Sbjct: 359 CSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLK--CSQVCEQHKH 416
Query: 492 SFRCGCMTGYILRPDERSCKPTGESPT-LLFSNRIGIRQVWLTGDNYMSVVKGLHNAVAL 550
+ +C C G+ L D SC ++FS R IR++ L +Y +V GL N +AL
Sbjct: 417 TVKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIAL 476
Query: 551 DYHYEKKLVFWSEN-NLRVIRVAQMNTKNMSD---VIRWGLETPAGVAVDWIHDLLFWTD 606
D+H+ + L++W++ R+ R + +S V+ GL TP G+ VDWI ++W D
Sbjct: 477 DFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWID 536
Query: 607 SGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPN-PKIERADMDGDK 665
S ++EVA LDGS R L+A ++ PRAIA+ P ++FWTDW N P+IE A M G
Sbjct: 537 SNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAG 596
Query: 666 RKTVIYD--EIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTT--KGLPHPF 721
RKT+ D WPNGLT+D+ E +I W DA+ I A +DG + ++ + L HPF
Sbjct: 597 RKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPF 656
Query: 722 ALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDI 764
A++L+ +YWTDW T ++S NK TG + + P D+
Sbjct: 657 AVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDL 699
Score = 223 bits (546), Expect = 3e-57
Identities = 136/396 (34%), Positives = 203/396 (51%), Gaps = 46/396 (11%)
Query: 762 MDIHSRSCEETP--EKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQK 819
+D+ SC E ++++ R ++R L + D + V +++ +ALD+
Sbjct: 428 LDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKR------DYSLLVPGLRNTIALDFHFN 481
Query: 820 SNSIFWTDVEKDTINRAYLNGSHQTT----IVDSNLIWPAGLAFDWITDKIYWTDGGTNR 875
+ ++WTDV +D I R L+ S + +V+ L P GL DWI IYW D ++
Sbjct: 482 QSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQ 541
Query: 876 IEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGAS-PCIERADMDGGNRKKLI 934
IEV+K DGS+RT L ++ PR I ++P G+++W+DW A+ P IE A M G RK +
Sbjct: 542 IEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIY 601
Query: 935 FGQMT--WPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLI---ENLPHPFGLDLY 989
T WPNGL +D RI WTD + I A DGT ++I E L HPF + LY
Sbjct: 602 KDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLY 661
Query: 990 GDEVFWTDWDTQSIQAANKDTGAK----RRTLG-------------------CGKNN--G 1024
G EV+WTDW T ++ ANK TG ++T C N+ G
Sbjct: 662 GSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKG 721
Query: 1025 GCSHLCLLKPG-GRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPYL-ID 1082
CSH+CL+ +CACP +KL+ D KTC + +L++A R +IR + +D PY
Sbjct: 722 PCSHMCLINHNRSAACACPHLMKLSSDKKTCYEMK-KFLLYARRSEIRGVDIDNPYFNFI 780
Query: 1083 VVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRA 1118
+P + + +D D S +YWTD + I+RA
Sbjct: 781 TAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRA 816
Score = 218 bits (533), Expect = 1e-55
Identities = 135/421 (32%), Positives = 217/421 (51%), Gaps = 27/421 (6%)
Query: 1022 NNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD-GPIN-YLIFAHRVDIRVISLDVPY 1079
N+ CS +C C+C G KL+ DG++C P ++IF+ R +IR I L +
Sbjct: 403 NHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDL---H 459
Query: 1080 LIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRA--TRLG--THVETVIGNGLHT 1135
D L +P L+N + +D + L+YWTD + +I R + G + +E V+ +GL T
Sbjct: 460 KRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLAT 519
Query: 1136 ADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSD 1195
+G+ +D IYW D + IEVA+LDG R L+ ++ PRAIAL YG +FW+D
Sbjct: 520 PEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTD 579
Query: 1196 WGTS-AKIERADMDGNNRRVIV-DNKI-KWPNGLAIDRIEGRLYWNDAKILTIESSDFDG 1252
W + +IE A M G R+ I D K WPNGL +D E R+ W DA+ I S+ +DG
Sbjct: 580 WDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDG 639
Query: 1253 HDRRTVLSNVPY---PYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDI 1309
+ ++ Y P+ + + G +YWTDW+T L +A+K + VI+K D+
Sbjct: 640 TNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDL 699
Query: 1310 RAIQSERVLE--NACGTDN--GGCSHLCL-RSPLGYTCACPTGMPFEKSTTDQTPKKCKS 1364
+ R + N C ++ G CSH+CL CACP M K ++D KK
Sbjct: 700 QIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACPHLM---KLSSD---KKTCY 753
Query: 1365 HPEEFLIFATRGSITYISLESPE-QWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVI 1423
++FL++A R I + +++P + V ++ + +D+ + +++TD+ I
Sbjct: 754 EMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTI 813
Query: 1424 R 1424
+
Sbjct: 814 K 814
Score = 205 bits (500), Expect = 1e-51
Identities = 127/376 (33%), Positives = 201/376 (53%), Gaps = 29/376 (7%)
Query: 1329 CSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKS-HP-EEFLIFATRGSITYISLESP 1386
CS +C + C+C +E D + C S P E F+IF+ R I I L
Sbjct: 407 CSQVCEQHKHTVKCSC-----YEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKR 461
Query: 1387 EQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTN---MSESKTIISQKLE 1443
D +L V ++NTIA+D+H++ ++++TD+ + I ++ +S + ++ L
Sbjct: 462 ---DYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLA 518
Query: 1444 TPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITGLTE-PRALALFPAKGYLYWS 1502
TP GL VDWIA NIYW D+ IEVA+LDGS R LI G E PRA+AL P G L+W+
Sbjct: 519 TPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWT 578
Query: 1503 DW-GEHPYIERSYLDGSQRQIIVQ-VDLG-FPNGLTIDYKERRLYWTDALKDRIDTSDLN 1559
DW P IE + + G+ R+ I + + G +PNGLT+D+ E+R+ WTDA D I ++ +
Sbjct: 579 DWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYD 638
Query: 1560 GQHRVQLVPD---AKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAME 1616
G + ++++ +PF ++ + +YWTDW ++ +A+K TG+N+++I+ +
Sbjct: 639 GTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFD 698
Query: 1617 IKAVSADRQ-HGWNPC--KESNGGCSHLCLF-RGHEYICACPD----DPDHVECSTVKML 1668
++ RQ NPC + G CSH+CL CACP D C +K
Sbjct: 699 LQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACPHLMKLSSDKKTCYEMKKF 758
Query: 1669 RNY-RDTELKDEEFSN 1683
Y R +E++ + N
Sbjct: 759 LLYARRSEIRGVDIDN 774
Score = 89.8 bits (213), Expect = 8e-17
Identities = 80/290 (27%), Positives = 137/290 (47%), Gaps = 23/290 (7%)
Query: 1019 CGKNNGGCSHLCLLKPG-GRSCACPIGIKLNKDGKTC--ADGPINYLIFAHRVDIRVISL 1075
C NNGGCS+ C + PG G C+CP G++LNKD KTC D N+L + + ++
Sbjct: 359 CSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTV 418
Query: 1076 DVPYLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHT 1135
L + ++ VD +I+ R+I L +++ GL
Sbjct: 419 KCSCYEGWKLDVDG-ESCTSVD-PFEAFIIFSIRHEIRRID----LHKRDYSLLVPGLRN 472
Query: 1136 ADGIVIDSTGRKIYWTDGGRNSI---EVAELDGRNR-KVLVWTGLDSPRAIALHYEYGYM 1191
+ +YWTD + I +++E G + +V+V GL +P + + + G +
Sbjct: 473 TIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNI 532
Query: 1192 FWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWN--DAKILTIESSD 1249
+W D +IE A +DG+ R ++ ++ P +A+D G L+W DA IES+
Sbjct: 533 YWID-SNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESAS 591
Query: 1250 FDGHDRRTVLSNV---PYPYGIVI--VGQHIYWTDWKTKALHRA--DKTN 1292
G R+T+ ++ +P G+ + + I WTD ++ A++ A D TN
Sbjct: 592 MSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTN 641
Score = 89.8 bits (213), Expect = 8e-17
Identities = 70/297 (23%), Positives = 128/297 (43%), Gaps = 23/297 (7%)
Query: 559 VFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTD--SGTRRVEVAT 616
++W ++NL I VA+++ + +I +E P +A+D + +LFWTD + R+E A+
Sbjct: 532 IYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESAS 591
Query: 617 LDGSKRAVLVANDLDK---PRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDE 673
+ G+ R + D+ P + V + + WTD + I A DG +I
Sbjct: 592 MSGAGRKTIY-KDMKTGAWPNGLTVDHFEKRIVWTD-ARSDAIYSALYDGTNMIEIIRGH 649
Query: 674 IFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDD----- 728
+ + + S++YW D + + + +A V K PF L ++
Sbjct: 650 EYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQ 709
Query: 729 -----AIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRK 783
A + +N N H + + ++C E +K LLYARR
Sbjct: 710 APNPCAANDGKGPCSHMCLINHNRSAACACPHL---MKLSSDKKTCYEM-KKFLLYARRS 765
Query: 784 DLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNG 840
++R +++ P + V I +D+D ++WTD++ TI RA++NG
Sbjct: 766 EIRGVDIDN--PYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFING 820
Score = 69.7 bits (163), Expect = 9e-11
Identities = 80/310 (25%), Positives = 129/310 (41%), Gaps = 26/310 (8%)
Query: 1301 KNLEGLMDIRAIQSERVLENACGTDNGGCSHLCLRSP-LGYTCACPTGMPFEK-STTDQT 1358
K G D E L + C +NGGCS+ C P G C+CP G+ K + T +
Sbjct: 338 KLCNGKKDCPDGSDEGYLCDECSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEI 397
Query: 1359 PKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDL 1418
C +H + + + E W + + + ++ +VD ++ +IF
Sbjct: 398 VDYCSNHLKCSQVCEQHKHT--VKCSCYEGWKLDV---DGESCTSVD-PFEAFIIFSI-- 449
Query: 1419 DLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSS-- 1476
+ IR I++ S ++ L L + + +YWTD I +L S
Sbjct: 450 -RHEIRRIDLHKRDYS--LLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGV 506
Query: 1477 ---RKVLITGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNG 1533
V+ GL P L + G +YW D IE + LDGS R ++ + P
Sbjct: 507 SAIEVVVEHGLATPEGLTVDWIAGNIYWID-SNLDQIEVAKLDGSLRTTLIAGAMEHPRA 565
Query: 1534 LTIDYKERRLYWT--DALKDRIDTSDLNGQHRVQLVPDAKN---PFGMT--QFKDYIYWT 1586
+ +D + L+WT DA RI+++ ++G R + D K P G+T F+ I WT
Sbjct: 566 IALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWT 625
Query: 1587 DWYKKSIIRA 1596
D +I A
Sbjct: 626 DARSDAIYSA 635
Score = 52.8 bits (121), Expect = 1e-05
Identities = 23/41 (56%), Positives = 27/41 (65%), Gaps = 1/41 (2%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCD 196
RSCD H+ + C ST CI W+CDGD DC D SDE +CD
Sbjct: 276 RSCD-HKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCD 315
Score = 33.9 bits (74), Expect = 5.3
Identities = 12/33 (36%), Positives = 20/33 (60%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDI 471
C +C+ ++ AACACP L+ DK +C ++
Sbjct: 723 CSHMCLINHNRSAACACPHLMKLSSDKKTCYEM 755
>AL606760-3|CAI18909.1| 700|Homo sapiens low density lipoprotein
receptor-related protein 8, apolipoprotein e receptor
protein.
Length = 700
Score = 383 bits (943), Expect = e-105
Identities = 192/514 (37%), Positives = 283/514 (55%), Gaps = 26/514 (5%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C + F+C+N +C+P ++CD D+DC D +DED CP +C +F C++G CI ERW+
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKK--TCADSDFTCDNGHCIHERWK 104
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCA--DRRCVLKTWLCDGVRDCTNGEDEMNC 380
CD E +C DG DE + C ++ +C +CV +W CDG +DC G DE C
Sbjct: 105 CDGEEECPDGSDESEATCTK-QVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
Query: 381 EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC--PLKRKCSAEEK 438
S TCR E + CV C+ +DCP G DE C L
Sbjct: 164 ATSLG----TCRGDEFQCGDG--TCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGG 217
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQTCSNTVGSFRCGC 497
C +C G C CP GF L + K +C DIDEC +DP CSQ C N G F+C C
Sbjct: 218 CSHICTDLKIGFE-CTCPAGFQLLDQK-TCGDIDEC---KDPDACSQICVNYKGYFKCEC 272
Query: 498 MTGYILRPDERSCKPT-GESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEK 556
GY + ++CK G+SP+L+F+NR +R++ L NY ++ L N VALD
Sbjct: 273 YPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVAT 332
Query: 557 KLVFWSENNLRVIRVAQMNT----KNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRV 612
++W + + R I A M+ K +I L +P G+AVDW+H ++WTDSG + +
Sbjct: 333 NRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTI 392
Query: 613 EVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYD 672
VAT+DG +R L + +L +PRAIAV P ++W+DWG KIE++ ++G R+T++ D
Sbjct: 393 SVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSD 452
Query: 673 EIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKV--TTKGLPHPFALTLFDDAI 730
I WPNG+T+D ++YW D+K H + F G +R+ + +T L HPF + +F+D +
Sbjct: 453 NIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKV 512
Query: 731 YWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDI 764
+WTD ++I + N+ G+ I + LN P DI
Sbjct: 513 FWTDLENEAIFSANRLNGLEISILAENLNNPHDI 546
Score = 220 bits (538), Expect = 3e-56
Identities = 124/349 (35%), Positives = 192/349 (55%), Gaps = 25/349 (7%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC--ADGPINYLIFAHRVDIRVISLDVP 1078
K+ CS +C+ G C C G +++ K C A G LIF +R ++R I L V
Sbjct: 252 KDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDL-VK 310
Query: 1079 YLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRA----TRLGTHVETVIGNGLH 1134
++P+ LKN + +DV+ +T IYW D RKI A E +I LH
Sbjct: 311 RNYSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH 368
Query: 1135 TADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWS 1194
+ +G+ +D + IYWTD G +I VA +DG R+ L L PRAIA+ G+M+WS
Sbjct: 369 SPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWS 428
Query: 1195 DWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHD 1254
DWG AKIE++ ++G +R+ +V + I+WPNG+ +D + RLYW D+K+ + S DF G +
Sbjct: 429 DWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGN 488
Query: 1255 RRTVLSN---VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDI-- 1309
R+T++S+ + +P+GI + ++WTD + +A+ A++ N + ++ +NL DI
Sbjct: 489 RKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVI 548
Query: 1310 -RAIQSERVLENACGTD---NGGCSHLCLRSPL------GYTCACPTGM 1348
++ R +AC NGGC +LCL +P YTCACP M
Sbjct: 549 FHELKQPRA-PDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTM 596
Score = 206 bits (504), Expect = 4e-52
Identities = 118/348 (33%), Positives = 186/348 (53%), Gaps = 23/348 (6%)
Query: 1325 DNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLE 1384
D CS +C+ + C C G + T + KS P LIF R + I L
Sbjct: 253 DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKS-PS--LIFTNRHEVRRIDLV 309
Query: 1385 SPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESK---TIISQK 1441
+ +P+ +KN +A+D I++ DL I S M S+ K +I ++
Sbjct: 310 K-RNYSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQ 366
Query: 1442 LETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLIT-GLTEPRALALFPAKGYLY 1500
L +P GL VDW+ +IYWTD+ +K I VA +DG R+ L + L+EPRA+A+ P +G++Y
Sbjct: 367 LHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMY 426
Query: 1501 WSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNG 1560
WSDWG+ IE+S L+G RQ +V ++ +PNG+T+D +RLYW D+ ++ + D +G
Sbjct: 427 WSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSG 486
Query: 1561 QHRVQLVPDA---KNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEI 1617
+R L+ +PFG+ F+D ++WTD ++I A++ G I+++ NL +I
Sbjct: 487 GNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDI 546
Query: 1618 KAVSADRQ-HGWNPCK---ESNGGCSHLCL----FRGH--EYICACPD 1655
+Q + C+ + NGGC +LCL H +Y CACPD
Sbjct: 547 VIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPD 594
Score = 177 bits (430), Expect = 4e-43
Identities = 116/365 (31%), Positives = 176/365 (48%), Gaps = 47/365 (12%)
Query: 762 MDIHSRSCEETPEKL--LLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQK 819
MD+ +++C+ K L++ R ++R L + + +IP+ +K+ VALD +
Sbjct: 278 MDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKR----NYSRLIPM--LKNVVALDVEVA 331
Query: 820 SNSIFWTDVEKDTINRAYLNGS----HQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNR 875
+N I+W D+ I AY++ + Q ++D L P GLA DW+ IYWTD G
Sbjct: 332 TNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKT 391
Query: 876 IEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIF 935
I V+ DG R L ++ +PR I V+P G MYWSDWG IE++ ++G +R+ L+
Sbjct: 392 ISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVS 451
Query: 936 GQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN---LPHPFGLDLYGDE 992
+ WPNG+ LDL+ R+YW D + + G R LI + L HPFG+ ++ D+
Sbjct: 452 DNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDK 511
Query: 993 VFWTDWDTQSIQAANKDTGAKRRTLGCGKN--------------------------NGGC 1026
VFWTD + ++I +AN+ G + L N NGGC
Sbjct: 512 VFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGC 571
Query: 1027 SHLCLLKPGGRS------CACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPYL 1080
+LCL P S CACP + L D K C V VI + VP +
Sbjct: 572 EYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRDANEDSKMGSTVTAAVIGIIVPIV 631
Query: 1081 IDVVL 1085
+ +L
Sbjct: 632 VIALL 636
Score = 113 bits (272), Expect = 5e-24
Identities = 112/461 (24%), Positives = 194/461 (42%), Gaps = 74/461 (16%)
Query: 344 RNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC-EVSCEEDQYTCRPQEHLMSNAF 402
++C D++ C + RC+ W CD DC + DE +C + +C + +TC N
Sbjct: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-------DNG- 96
Query: 403 RNCVNRKHVCDGMKDCPRGDDE-ERCPLKRKCSAEE--------KC---------EKLCI 444
+C++ + CDG ++CP G DE E K+ C AE+ KC EK C
Sbjct: 97 -HCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCE 155
Query: 445 TTYDGHAACACPMGFLLAEDKYSCRD------IDECMYEQD------------------- 479
D A CA +G D++ C D I C EQD
Sbjct: 156 GGAD-EAGCATSLG-TCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLH 213
Query: 480 --PVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIR-QVWLTGDN 536
CS C++ F C C G+ L D+++C E ++I + + + +
Sbjct: 214 NNGGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICVNYKGYFKCEC 272
Query: 537 YMSVVKGL--HNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVA 594
Y L N A L+F + + +R I + + N + + L+ +
Sbjct: 273 YPGYEMDLLTKNCKAA-AGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM----LKNVVALD 327
Query: 595 VDWIHDLLFWTDSGTRRVEVATLDGS----KRAVLVANDLDKPRAIAVHPGDALVFWTDW 650
V+ + ++W D R++ A +D + ++ VL+ L P +AV ++WTD
Sbjct: 328 VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDS 387
Query: 651 GPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWAD-AKHHVIERAAFDGRDR 709
G N I A +DG +R+T+ + P + +D +YW+D IE++ +G DR
Sbjct: 388 G-NKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDR 446
Query: 710 RKVTTKGL--PHPFALTLFDDAIYWTDWHTKSISTVNKNTG 748
+ + + + P+ L L +YW D +S+++ + G
Sbjct: 447 QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGG 487
Score = 102 bits (245), Expect = 1e-20
Identities = 77/281 (27%), Positives = 127/281 (45%), Gaps = 18/281 (6%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVP 1078
C NNGGCSH+C G C CP G +L D KTC D I+ ++
Sbjct: 211 CLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGD--IDECKDPDACSQICVNYKGY 267
Query: 1079 YLIDVV--LPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTA 1136
+ + + L S LI+ T + +++R + + +I L
Sbjct: 268 FKCECYPGYEMDLLTKNCKAAAGKSPSLIF---TNRHEVRRIDLVKRNYSRLIPM-LKNV 323
Query: 1137 DGIVIDSTGRKIYWTDGGRNSIEVAEL----DGRNRKVLVWTGLDSPRAIALHYEYGYMF 1192
+ ++ +IYW D I A + D + ++VL+ L SP +A+ + + +++
Sbjct: 324 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 383
Query: 1193 WSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFD 1251
W+D G I A +DG RR + + P +A+D + G +YW+D IE S +
Sbjct: 384 WTDSGNKT-ISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 442
Query: 1252 GHDRRTVLS-NVPYPYGIV--IVGQHIYWTDWKTKALHRAD 1289
G DR+T++S N+ +P GI ++ Q +YW D K L D
Sbjct: 443 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSID 483
Score = 91.5 bits (217), Expect = 3e-17
Identities = 82/297 (27%), Positives = 129/297 (43%), Gaps = 21/297 (7%)
Query: 1320 NACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSIT 1379
N C +NGGCSH+C +G+ C CP G T +CK P+
Sbjct: 209 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD-PDACSQICVNYK-G 266
Query: 1380 YISLESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIIS 1439
Y E +++ L K K +IF + + +R I++ + S+ I
Sbjct: 267 YFKCECYPGYEMDLLTKNCKAAAGK----SPSLIF---TNRHEVRRIDLVKRNYSRLI-- 317
Query: 1440 QKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSS----RKVLI-TGLTEPRALALFP 1494
L+ L V+ N IYW D ++ I A +D +S ++VLI L P LA+
Sbjct: 318 PMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDW 377
Query: 1495 AKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTD-ALKDRI 1553
++YW+D G + I + +DG +R+ + +L P + +D +YW+D + +I
Sbjct: 378 VHKHIYWTDSG-NKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKI 436
Query: 1554 DTSDLNGQHRVQLVPD-AKNPFGMT--QFKDYIYWTDWYKKSIIRADKRTGKNITLI 1607
+ S LNG R LV D + P G+T +YW D + D G TLI
Sbjct: 437 EKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLI 493
Score = 82.6 bits (195), Expect = 1e-14
Identities = 53/168 (31%), Positives = 74/168 (44%), Gaps = 24/168 (14%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
CI W CD D+DC D SDE +C KT ++ + + G I
Sbjct: 59 CIPSVWRCDEDDDCLDHSDEDDCP-KKT---CADSDFTCDNGHCIHE------------- 101
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNT--KCVPKDFQCDGDNDCGD 290
R++ ++ D + +T + V C C T KCVP ++CDG+ DC
Sbjct: 102 -RWKCDGEEECPDGSDESEATCTKQV----CPAEKLSCGPTSHKCVPASWRCDGEKDCEG 156
Query: 291 WTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNC 338
DE C G+C EF+C DG C+ C+ E+DC DG DE C
Sbjct: 157 GADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 204
Score = 54.0 bits (124), Expect = 5e-06
Identities = 54/233 (23%), Positives = 102/233 (43%), Gaps = 20/233 (8%)
Query: 680 LTIDYTESKIYWADAKHHVIERA----AFDGRDRRKVTTKGL--PHPFALTLFDDAIYWT 733
L ++ ++IYW D + I A A D +++ + + L P A+ IYWT
Sbjct: 326 LDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWT 385
Query: 734 DWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESK 793
D K+IS + G L+ P R+ P + +Y D + K
Sbjct: 386 DSGNKTISVATVDGGRRRTLFSRNLSEP-----RAIAVDPLRGFMYW--SDWGDQAKIEK 438
Query: 794 KPIDSLD-MVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSN-- 850
++ +D + + I+ + D S ++W D + ++ +G ++ T++ S
Sbjct: 439 SGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDF 498
Query: 851 LIWPAGLAFDWITDKIYWTDGGTNRI-EVSKSDGSMRTLLAWDHIDKPRDIVV 902
L P G+A DK++WTD I ++ +G ++LA ++++ P DIV+
Sbjct: 499 LSHPFGIAV--FEDKVFWTDLENEAIFSANRLNGLEISILA-ENLNNPHDIVI 548
Score = 35.9 bits (79), Expect = 1.3
Identities = 13/28 (46%), Positives = 16/28 (57%)
Query: 1627 GWNPCKESNGGCSHLCLFRGHEYICACP 1654
G N C +NGGCSH+C + C CP
Sbjct: 207 GLNECLHNNGGCSHICTDLKIGFECTCP 234
Score = 34.7 bits (76), Expect = 3.1
Identities = 26/101 (25%), Positives = 40/101 (39%), Gaps = 8/101 (7%)
Query: 99 DPDDGPLNEGTEDDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSC 158
D DD L+ EDD T C +F+C + CI +R +C
Sbjct: 67 DEDDDCLDHSDEDDCPKKT-CADSDFTCD-NGHCI--HERWKCDGEEECPDGSDESEATC 122
Query: 159 DEH----ENRTICHSTNVCIALEWLCDGDNDCGDFSDEINC 195
+ E + +++ C+ W CDG+ DC +DE C
Sbjct: 123 TKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
>AL355483-3|CAI22782.1| 700|Homo sapiens low density lipoprotein
receptor-related protein 8, apolipoprotein e receptor
protein.
Length = 700
Score = 383 bits (943), Expect = e-105
Identities = 192/514 (37%), Positives = 283/514 (55%), Gaps = 26/514 (5%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C + F+C+N +C+P ++CD D+DC D +DED CP +C +F C++G CI ERW+
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKK--TCADSDFTCDNGHCIHERWK 104
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCA--DRRCVLKTWLCDGVRDCTNGEDEMNC 380
CD E +C DG DE + C ++ +C +CV +W CDG +DC G DE C
Sbjct: 105 CDGEEECPDGSDESEATCTK-QVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
Query: 381 EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC--PLKRKCSAEEK 438
S TCR E + CV C+ +DCP G DE C L
Sbjct: 164 ATSLG----TCRGDEFQCGDG--TCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGG 217
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQTCSNTVGSFRCGC 497
C +C G C CP GF L + K +C DIDEC +DP CSQ C N G F+C C
Sbjct: 218 CSHICTDLKIGFE-CTCPAGFQLLDQK-TCGDIDEC---KDPDACSQICVNYKGYFKCEC 272
Query: 498 MTGYILRPDERSCKPT-GESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEK 556
GY + ++CK G+SP+L+F+NR +R++ L NY ++ L N VALD
Sbjct: 273 YPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVAT 332
Query: 557 KLVFWSENNLRVIRVAQMNT----KNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRV 612
++W + + R I A M+ K +I L +P G+AVDW+H ++WTDSG + +
Sbjct: 333 NRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTI 392
Query: 613 EVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYD 672
VAT+DG +R L + +L +PRAIAV P ++W+DWG KIE++ ++G R+T++ D
Sbjct: 393 SVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSD 452
Query: 673 EIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKV--TTKGLPHPFALTLFDDAI 730
I WPNG+T+D ++YW D+K H + F G +R+ + +T L HPF + +F+D +
Sbjct: 453 NIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKV 512
Query: 731 YWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDI 764
+WTD ++I + N+ G+ I + LN P DI
Sbjct: 513 FWTDLENEAIFSANRLNGLEISILAENLNNPHDI 546
Score = 220 bits (538), Expect = 3e-56
Identities = 124/349 (35%), Positives = 192/349 (55%), Gaps = 25/349 (7%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC--ADGPINYLIFAHRVDIRVISLDVP 1078
K+ CS +C+ G C C G +++ K C A G LIF +R ++R I L V
Sbjct: 252 KDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDL-VK 310
Query: 1079 YLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRA----TRLGTHVETVIGNGLH 1134
++P+ LKN + +DV+ +T IYW D RKI A E +I LH
Sbjct: 311 RNYSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH 368
Query: 1135 TADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWS 1194
+ +G+ +D + IYWTD G +I VA +DG R+ L L PRAIA+ G+M+WS
Sbjct: 369 SPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWS 428
Query: 1195 DWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHD 1254
DWG AKIE++ ++G +R+ +V + I+WPNG+ +D + RLYW D+K+ + S DF G +
Sbjct: 429 DWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGN 488
Query: 1255 RRTVLSN---VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDI-- 1309
R+T++S+ + +P+GI + ++WTD + +A+ A++ N + ++ +NL DI
Sbjct: 489 RKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVI 548
Query: 1310 -RAIQSERVLENACGTD---NGGCSHLCLRSPL------GYTCACPTGM 1348
++ R +AC NGGC +LCL +P YTCACP M
Sbjct: 549 FHELKQPRA-PDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTM 596
Score = 206 bits (504), Expect = 4e-52
Identities = 118/348 (33%), Positives = 186/348 (53%), Gaps = 23/348 (6%)
Query: 1325 DNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLE 1384
D CS +C+ + C C G + T + KS P LIF R + I L
Sbjct: 253 DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKS-PS--LIFTNRHEVRRIDLV 309
Query: 1385 SPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESK---TIISQK 1441
+ +P+ +KN +A+D I++ DL I S M S+ K +I ++
Sbjct: 310 K-RNYSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQ 366
Query: 1442 LETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLIT-GLTEPRALALFPAKGYLY 1500
L +P GL VDW+ +IYWTD+ +K I VA +DG R+ L + L+EPRA+A+ P +G++Y
Sbjct: 367 LHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMY 426
Query: 1501 WSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNG 1560
WSDWG+ IE+S L+G RQ +V ++ +PNG+T+D +RLYW D+ ++ + D +G
Sbjct: 427 WSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSG 486
Query: 1561 QHRVQLVPDA---KNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEI 1617
+R L+ +PFG+ F+D ++WTD ++I A++ G I+++ NL +I
Sbjct: 487 GNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDI 546
Query: 1618 KAVSADRQ-HGWNPCK---ESNGGCSHLCL----FRGH--EYICACPD 1655
+Q + C+ + NGGC +LCL H +Y CACPD
Sbjct: 547 VIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPD 594
Score = 177 bits (430), Expect = 4e-43
Identities = 116/365 (31%), Positives = 176/365 (48%), Gaps = 47/365 (12%)
Query: 762 MDIHSRSCEETPEKL--LLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQK 819
MD+ +++C+ K L++ R ++R L + + +IP+ +K+ VALD +
Sbjct: 278 MDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKR----NYSRLIPM--LKNVVALDVEVA 331
Query: 820 SNSIFWTDVEKDTINRAYLNGS----HQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNR 875
+N I+W D+ I AY++ + Q ++D L P GLA DW+ IYWTD G
Sbjct: 332 TNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKT 391
Query: 876 IEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIF 935
I V+ DG R L ++ +PR I V+P G MYWSDWG IE++ ++G +R+ L+
Sbjct: 392 ISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVS 451
Query: 936 GQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN---LPHPFGLDLYGDE 992
+ WPNG+ LDL+ R+YW D + + G R LI + L HPFG+ ++ D+
Sbjct: 452 DNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDK 511
Query: 993 VFWTDWDTQSIQAANKDTGAKRRTLGCGKN--------------------------NGGC 1026
VFWTD + ++I +AN+ G + L N NGGC
Sbjct: 512 VFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGC 571
Query: 1027 SHLCLLKPGGRS------CACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPYL 1080
+LCL P S CACP + L D K C V VI + VP +
Sbjct: 572 EYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRDANEDSKMGSTVTAAVIGIIVPIV 631
Query: 1081 IDVVL 1085
+ +L
Sbjct: 632 VIALL 636
Score = 113 bits (272), Expect = 5e-24
Identities = 112/461 (24%), Positives = 194/461 (42%), Gaps = 74/461 (16%)
Query: 344 RNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC-EVSCEEDQYTCRPQEHLMSNAF 402
++C D++ C + RC+ W CD DC + DE +C + +C + +TC N
Sbjct: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-------DNG- 96
Query: 403 RNCVNRKHVCDGMKDCPRGDDE-ERCPLKRKCSAEE--------KC---------EKLCI 444
+C++ + CDG ++CP G DE E K+ C AE+ KC EK C
Sbjct: 97 -HCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCE 155
Query: 445 TTYDGHAACACPMGFLLAEDKYSCRD------IDECMYEQD------------------- 479
D A CA +G D++ C D I C EQD
Sbjct: 156 GGAD-EAGCATSLG-TCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLH 213
Query: 480 --PVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIR-QVWLTGDN 536
CS C++ F C C G+ L D+++C E ++I + + + +
Sbjct: 214 NNGGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICVNYKGYFKCEC 272
Query: 537 YMSVVKGL--HNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVA 594
Y L N A L+F + + +R I + + N + + L+ +
Sbjct: 273 YPGYEMDLLTKNCKAA-AGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM----LKNVVALD 327
Query: 595 VDWIHDLLFWTDSGTRRVEVATLDGS----KRAVLVANDLDKPRAIAVHPGDALVFWTDW 650
V+ + ++W D R++ A +D + ++ VL+ L P +AV ++WTD
Sbjct: 328 VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDS 387
Query: 651 GPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWAD-AKHHVIERAAFDGRDR 709
G N I A +DG +R+T+ + P + +D +YW+D IE++ +G DR
Sbjct: 388 G-NKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDR 446
Query: 710 RKVTTKGL--PHPFALTLFDDAIYWTDWHTKSISTVNKNTG 748
+ + + + P+ L L +YW D +S+++ + G
Sbjct: 447 QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGG 487
Score = 102 bits (245), Expect = 1e-20
Identities = 77/281 (27%), Positives = 127/281 (45%), Gaps = 18/281 (6%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVP 1078
C NNGGCSH+C G C CP G +L D KTC D I+ ++
Sbjct: 211 CLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGD--IDECKDPDACSQICVNYKGY 267
Query: 1079 YLIDVV--LPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTA 1136
+ + + L S LI+ T + +++R + + +I L
Sbjct: 268 FKCECYPGYEMDLLTKNCKAAAGKSPSLIF---TNRHEVRRIDLVKRNYSRLIPM-LKNV 323
Query: 1137 DGIVIDSTGRKIYWTDGGRNSIEVAEL----DGRNRKVLVWTGLDSPRAIALHYEYGYMF 1192
+ ++ +IYW D I A + D + ++VL+ L SP +A+ + + +++
Sbjct: 324 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 383
Query: 1193 WSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFD 1251
W+D G I A +DG RR + + P +A+D + G +YW+D IE S +
Sbjct: 384 WTDSGNKT-ISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 442
Query: 1252 GHDRRTVLS-NVPYPYGIV--IVGQHIYWTDWKTKALHRAD 1289
G DR+T++S N+ +P GI ++ Q +YW D K L D
Sbjct: 443 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSID 483
Score = 91.5 bits (217), Expect = 3e-17
Identities = 82/297 (27%), Positives = 129/297 (43%), Gaps = 21/297 (7%)
Query: 1320 NACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSIT 1379
N C +NGGCSH+C +G+ C CP G T +CK P+
Sbjct: 209 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD-PDACSQICVNYK-G 266
Query: 1380 YISLESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIIS 1439
Y E +++ L K K +IF + + +R I++ + S+ I
Sbjct: 267 YFKCECYPGYEMDLLTKNCKAAAGK----SPSLIF---TNRHEVRRIDLVKRNYSRLI-- 317
Query: 1440 QKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSS----RKVLI-TGLTEPRALALFP 1494
L+ L V+ N IYW D ++ I A +D +S ++VLI L P LA+
Sbjct: 318 PMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDW 377
Query: 1495 AKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTD-ALKDRI 1553
++YW+D G + I + +DG +R+ + +L P + +D +YW+D + +I
Sbjct: 378 VHKHIYWTDSG-NKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKI 436
Query: 1554 DTSDLNGQHRVQLVPD-AKNPFGMT--QFKDYIYWTDWYKKSIIRADKRTGKNITLI 1607
+ S LNG R LV D + P G+T +YW D + D G TLI
Sbjct: 437 EKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLI 493
Score = 82.6 bits (195), Expect = 1e-14
Identities = 53/168 (31%), Positives = 74/168 (44%), Gaps = 24/168 (14%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
CI W CD D+DC D SDE +C KT ++ + + G I
Sbjct: 59 CIPSVWRCDEDDDCLDHSDEDDCP-KKT---CADSDFTCDNGHCIHE------------- 101
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNT--KCVPKDFQCDGDNDCGD 290
R++ ++ D + +T + V C C T KCVP ++CDG+ DC
Sbjct: 102 -RWKCDGEEECPDGSDESEATCTKQV----CPAEKLSCGPTSHKCVPASWRCDGEKDCEG 156
Query: 291 WTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNC 338
DE C G+C EF+C DG C+ C+ E+DC DG DE C
Sbjct: 157 GADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 204
Score = 54.0 bits (124), Expect = 5e-06
Identities = 54/233 (23%), Positives = 102/233 (43%), Gaps = 20/233 (8%)
Query: 680 LTIDYTESKIYWADAKHHVIERA----AFDGRDRRKVTTKGL--PHPFALTLFDDAIYWT 733
L ++ ++IYW D + I A A D +++ + + L P A+ IYWT
Sbjct: 326 LDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWT 385
Query: 734 DWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESK 793
D K+IS + G L+ P R+ P + +Y D + K
Sbjct: 386 DSGNKTISVATVDGGRRRTLFSRNLSEP-----RAIAVDPLRGFMYW--SDWGDQAKIEK 438
Query: 794 KPIDSLD-MVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSN-- 850
++ +D + + I+ + D S ++W D + ++ +G ++ T++ S
Sbjct: 439 SGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDF 498
Query: 851 LIWPAGLAFDWITDKIYWTDGGTNRI-EVSKSDGSMRTLLAWDHIDKPRDIVV 902
L P G+A DK++WTD I ++ +G ++LA ++++ P DIV+
Sbjct: 499 LSHPFGIAV--FEDKVFWTDLENEAIFSANRLNGLEISILA-ENLNNPHDIVI 548
Score = 35.9 bits (79), Expect = 1.3
Identities = 13/28 (46%), Positives = 16/28 (57%)
Query: 1627 GWNPCKESNGGCSHLCLFRGHEYICACP 1654
G N C +NGGCSH+C + C CP
Sbjct: 207 GLNECLHNNGGCSHICTDLKIGFECTCP 234
Score = 34.7 bits (76), Expect = 3.1
Identities = 26/101 (25%), Positives = 40/101 (39%), Gaps = 8/101 (7%)
Query: 99 DPDDGPLNEGTEDDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSC 158
D DD L+ EDD T C +F+C + CI +R +C
Sbjct: 67 DEDDDCLDHSDEDDCPKKT-CADSDFTCD-NGHCI--HERWKCDGEEECPDGSDESEATC 122
Query: 159 DEH----ENRTICHSTNVCIALEWLCDGDNDCGDFSDEINC 195
+ E + +++ C+ W CDG+ DC +DE C
Sbjct: 123 TKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
>S73849-1|AAB31735.1| 873|Homo sapiens very low density lipoprotein
receptor protein.
Length = 873
Score = 381 bits (937), Expect = e-104
Identities = 213/625 (34%), Positives = 330/625 (52%), Gaps = 60/625 (9%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
R+C HE HST CI + W CDG+ND CD S N G+
Sbjct: 111 RTCRIHEISCGAHSTQ-CIPVSWRCDGEND---------CD---------SGEDEENCGN 151
Query: 216 VITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELM--RCAEIDFECKNT 273
+ +P + + ++ + N + S + ++ C +F+C +
Sbjct: 152 ITCSPDEFTCSSGRCI--------SRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTS 203
Query: 274 KCVPKDFQCDGDNDCGDWTDE--DSC---PMVPGSCNAGEFKCNDGKCIPERWRCDNERD 328
C+P + CD D DC D +DE + C P++ C A E +C G+CI ++WRCD + D
Sbjct: 204 SCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPD 263
Query: 329 CADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV--SC-E 385
C DG DE+NC P+ R C D++ C D C+ + C+G+RDC +G DE+NC+ C
Sbjct: 264 CKDGSDEVNC-PS--RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLG 320
Query: 386 EDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE--ERCPLKRKCSAEEKCEKLC 443
++ CR E C++ VC+ +DC DE + C + C +C
Sbjct: 321 PGKFKCRSGE---------CIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHIC 371
Query: 444 ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQTCSNTVGSFRCGCMTGYI 502
G+ C C GF L D+ +C DIDEC Q+P +CSQ C N G ++C C GY
Sbjct: 372 KDLVIGYE-CDCAAGFELI-DRKTCGDIDEC---QNPGICSQICINLKGGYKCECSRGYQ 426
Query: 503 LRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLVFWS 562
+ CK G+ P+L+F+NR IR++ L Y+ +V+ L N VALD + +FW+
Sbjct: 427 MDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWA 486
Query: 563 ENNLRVIRVAQMNTKNMSDV-IRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSK 621
+ + + I A ++ K V + + PA +AVDW++ ++WTD+ ++ + VATLDG+K
Sbjct: 487 DLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTK 546
Query: 622 RAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLT 681
R L +DL +P +IAV P V+W+DWG KIE+A M+G R+ ++ +I WPNG+T
Sbjct: 547 RKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGIT 606
Query: 682 IDYTESKIYWADAKHHVIERAAFDGRDRRKV--TTKGLPHPFALTLFDDAIYWTDWHTKS 739
+D +S++YW D+K H++ +G+DRR V + + L HP ALT+F+D +YW D ++
Sbjct: 607 LDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEA 666
Query: 740 ISTVNKNTGMGIQTVHAGLNVPMDI 764
+ NK TG + T+ LN DI
Sbjct: 667 VYGANKFTGSELATLVNNLNDAQDI 691
Score = 219 bits (535), Expect = 7e-56
Identities = 127/354 (35%), Positives = 192/354 (54%), Gaps = 24/354 (6%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGPINYLIFAHRVDIRVISLDVPY 1079
+N G CS +C+ GG C C G +++ C A G LIF +R DIR I L+
Sbjct: 401 QNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKE 460
Query: 1080 LIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRAT---RLGTHVETVIGNGLHTA 1136
I +V L+N + +D D + ++W D Q+ I A+ ++G HV+ + + ++
Sbjct: 461 YIQLV---EQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNP 515
Query: 1137 DGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDW 1196
I +D + IYWTD +I VA LDG RK L + L P +IA+ G+++WSDW
Sbjct: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
Query: 1197 GTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRR 1256
G AKIE+A M+G +RR +V I+WPNG+ +D I+ RLYW D+K+ + S D +G DRR
Sbjct: 576 GEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRR 635
Query: 1257 TVLSNVPY---PYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQ 1313
VL ++ + P + I +YW D + +A++ A+K S+ + NL DI +
Sbjct: 636 IVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDI-IVY 694
Query: 1314 SERVL---ENACGTD--NGGCSHLCLRSPL------GYTCACPTGMPFEKSTTD 1356
E V +N C D NGGC +LCL +P YTC+CP+G E++ D
Sbjct: 695 HELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRD 748
Score = 202 bits (492), Expect = 1e-50
Identities = 123/379 (32%), Positives = 193/379 (50%), Gaps = 27/379 (7%)
Query: 1327 GGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEE-FLIFATRGSITYISLES 1385
G CS +C+ GY C C G + +T CK+ +E LIF R I I LE
Sbjct: 404 GICSQICINLKGGYKCECSRGYQMDLATG-----VCKAVGKEPSLIFTNRRDIRKIGLER 458
Query: 1386 PEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETP 1445
E + V++++NT+A+D + +F+ DL I S ++ + + + P
Sbjct: 459 KEYIQL---VEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNP 515
Query: 1446 NGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITG-LTEPRALALFPAKGYLYWSDW 1504
+ VDW+ IYWTD K I VA LDG+ RK L L EP ++A+ P G++YWSDW
Sbjct: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
Query: 1505 GEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHR- 1563
GE IE++ ++G R+ +V D+ +PNG+T+D + RLYW D+ + + DLNGQ R
Sbjct: 576 GEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRR 635
Query: 1564 --VQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAV- 1620
++ + +P +T F+D +YW D +++ A+K TG + + NL A +I
Sbjct: 636 IVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYH 695
Query: 1621 SADRQHGWNPCKE--SNGGCSHLCL----FRGH--EYICACPD----DPDHVECSTVKML 1668
+ G N C+E NGGC +LCL H +Y C+CP + + +C +
Sbjct: 696 ELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATT 755
Query: 1669 RNYRDT-ELKDEEFSNSTG 1686
Y +T + E S ++G
Sbjct: 756 VTYSETKDTNTTEISATSG 774
Score = 180 bits (438), Expect = 4e-44
Identities = 110/331 (33%), Positives = 167/331 (50%), Gaps = 46/331 (13%)
Query: 762 MDIHSRSCEET-PEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKS 820
MD+ + C+ E L++ R+D+R LE K+ I VE +++ VALD D +
Sbjct: 427 MDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQL------VEQLRNTVALDADIAA 480
Query: 821 NSIFWTDVEKDTINRAYLN---GSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIE 877
+FW D+ + I A ++ G H I N+ PA +A DW+ IYWTD + I
Sbjct: 481 QKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNPAAIAVDWVYKTIYWTDAASKTIS 538
Query: 878 VSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQ 937
V+ DG+ R L + +P I V+P G +YWSDWG IE+A M+G +R+ L+
Sbjct: 539 VATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTAD 598
Query: 938 MTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGR---TKLIENLPHPFGLDLYGDEVF 994
+ WPNG+ LDL+ +R+YW D + +L+G R K +E L HP L ++ D V+
Sbjct: 599 IQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVY 658
Query: 995 WTDWDTQSIQAANKDTGAKRRTL------------------GCGKN-------NGGCSHL 1029
W D + +++ ANK TG++ TL GKN NGGC +L
Sbjct: 659 WIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYL 718
Query: 1030 CLLKP------GGRSCACPIGIKLNKDGKTC 1054
CL P +C+CP G + ++G+ C
Sbjct: 719 CLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749
Score = 151 bits (365), Expect = 3e-35
Identities = 68/179 (37%), Positives = 100/179 (55%), Gaps = 16/179 (8%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
+C F+C N +C+ ++CDGD DC D +DE +C V +C +F CN+G+C+P RW
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC--VKKTCAESDFVCNNGQCVPSRW 89
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCA--DRRCVLKTWLCDGVRDCTNGEDEMN 379
+CD + DC DG DE + + +R C + E +C +C+ +W CDG DC +GEDE N
Sbjct: 90 KCDGDPDCEDGSDE-SPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEEN 148
Query: 380 C-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE 437
C ++C D++TC + C++R VC+G DC G DE C C A E
Sbjct: 149 CGNITCSPDEFTC---------SSGRCISRNFVCNGQDDCSDGSDELDC-APPTCGAHE 197
Score = 102 bits (244), Expect = 1e-20
Identities = 83/294 (28%), Positives = 135/294 (45%), Gaps = 15/294 (5%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVP 1078
C NNGGCSH+C G C C G +L D KTC D I+ I+L
Sbjct: 360 CLVNNGGCSHICKDLVIGYECDCAAGFEL-IDRKTCGD--IDECQNPGICSQICINLKGG 416
Query: 1079 YLIDVVLPLP-PLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTAD 1137
Y + L + V LI+ RKI + +++ V L
Sbjct: 417 YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERK--EYIQLV--EQLRNTV 472
Query: 1138 GIVIDSTGRKIYWTDGGRNSIEVAELDGR-NRKVLVWTGLDSPRAIALHYEYGYMFWSDW 1196
+ D +K++W D + +I A +D + R V + + +P AIA+ + Y ++W+D
Sbjct: 473 ALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD- 531
Query: 1197 GTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFDGHDR 1255
S I A +DG R+ + ++ ++ P +A+D + G +YW+D + IE + +G DR
Sbjct: 532 AASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDR 591
Query: 1256 R-TVLSNVPYPYGIV--IVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGL 1306
R V +++ +P GI ++ +YW D K L D N D ++ K+LE L
Sbjct: 592 RPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVD-LNGQDRRIVLKSLEFL 644
Score = 74.5 bits (175), Expect = 3e-12
Identities = 83/332 (25%), Positives = 134/332 (40%), Gaps = 23/332 (6%)
Query: 1290 KTNASDPIVIRKNLEGLMDIRAIQSERVLE---NACGTDNGGCSHLCLRSPLGYTCACPT 1346
K + + I I K D R E + E N C +NGGCSH+C +GY C C
Sbjct: 325 KCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAA 384
Query: 1347 GMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDY 1406
G T +C++ I Q D+ V +
Sbjct: 385 GFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGK----- 439
Query: 1407 HWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKV 1466
+ +IF D IR I + + + ++L L D A ++W D K
Sbjct: 440 --EPSLIFTNRRD---IRKIGLERKEYIQLV--EQLRNTVALDADIAAQKLFWADLSQKA 492
Query: 1467 IEVARLDGS-SRKV-LITGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIV 1524
I A +D R V +I + P A+A+ +YW+D I + LDG++R+ +
Sbjct: 493 IFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD-AASKTISVATLDGTKRKFLF 551
Query: 1525 QVDLGFPNGLTIDYKERRLYWTD-ALKDRIDTSDLNGQHRVQLV-PDAKNPFGMT--QFK 1580
DL P + +D +YW+D +I+ + +NG R LV D + P G+T K
Sbjct: 552 NSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIK 611
Query: 1581 DYIYWTDWYKKSIIRADKRTGKNITLIRTNLE 1612
+YW D K ++ + G++ ++ +LE
Sbjct: 612 SRLYWLD-SKLHMLSSVDLNGQDRRIVLKSLE 642
Score = 41.5 bits (93), Expect = 0.027
Identities = 19/28 (67%), Positives = 19/28 (67%), Gaps = 1/28 (3%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKT 200
CI L W CDGD DC D SDE NC V KT
Sbjct: 45 CITLLWKCDGDEDCVDGSDEKNC-VKKT 71
Score = 35.1 bits (77), Expect = 2.3
Identities = 14/31 (45%), Positives = 19/31 (61%), Gaps = 1/31 (3%)
Query: 162 ENRTICHSTNVCIALEWLCDGDNDCGDFSDE 192
E+ +C++ C+ W CDGD DC D SDE
Sbjct: 74 ESDFVCNNGQ-CVPSRWKCDGDPDCEDGSDE 103
>L22431-1|AAA61344.1| 873|Homo sapiens very low density lipoprotein
receptor protein.
Length = 873
Score = 381 bits (937), Expect = e-104
Identities = 213/625 (34%), Positives = 330/625 (52%), Gaps = 60/625 (9%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
R+C HE HST CI + W CDG+ND CD S N G+
Sbjct: 111 RTCRIHEISCGAHSTQ-CIPVSWRCDGEND---------CD---------SGEDEENCGN 151
Query: 216 VITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELM--RCAEIDFECKNT 273
+ +P + + ++ + N + S + ++ C +F+C +
Sbjct: 152 ITCSPDEFTCSSGRCI--------SRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTS 203
Query: 274 KCVPKDFQCDGDNDCGDWTDE--DSC---PMVPGSCNAGEFKCNDGKCIPERWRCDNERD 328
C+P + CD D DC D +DE + C P++ C A E +C G+CI ++WRCD + D
Sbjct: 204 SCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPD 263
Query: 329 CADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV--SC-E 385
C DG DE+NC P+ R C D++ C D C+ + C+G+RDC +G DE+NC+ C
Sbjct: 264 CKDGSDEVNC-PS--RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLG 320
Query: 386 EDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE--ERCPLKRKCSAEEKCEKLC 443
++ CR E C++ VC+ +DC DE + C + C +C
Sbjct: 321 PGKFKCRSGE---------CIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHIC 371
Query: 444 ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQTCSNTVGSFRCGCMTGYI 502
G+ C C GF L D+ +C DIDEC Q+P +CSQ C N G ++C C GY
Sbjct: 372 KDLVIGYE-CDCAAGFELI-DRKTCGDIDEC---QNPGICSQICINLKGGYKCECSRGYQ 426
Query: 503 LRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLVFWS 562
+ CK G+ P+L+F+NR IR++ L Y+ +V+ L N VALD + +FW+
Sbjct: 427 MDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWA 486
Query: 563 ENNLRVIRVAQMNTKNMSDV-IRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSK 621
+ + + I A ++ K V + + PA +AVDW++ ++WTD+ ++ + VATLDG+K
Sbjct: 487 DLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTK 546
Query: 622 RAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLT 681
R L +DL +P +IAV P V+W+DWG KIE+A M+G R+ ++ +I WPNG+T
Sbjct: 547 RKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGIT 606
Query: 682 IDYTESKIYWADAKHHVIERAAFDGRDRRKV--TTKGLPHPFALTLFDDAIYWTDWHTKS 739
+D +S++YW D+K H++ +G+DRR V + + L HP ALT+F+D +YW D ++
Sbjct: 607 LDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEA 666
Query: 740 ISTVNKNTGMGIQTVHAGLNVPMDI 764
+ NK TG + T+ LN DI
Sbjct: 667 VYGANKFTGSELATLVNNLNDAQDI 691
Score = 219 bits (535), Expect = 7e-56
Identities = 127/354 (35%), Positives = 192/354 (54%), Gaps = 24/354 (6%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGPINYLIFAHRVDIRVISLDVPY 1079
+N G CS +C+ GG C C G +++ C A G LIF +R DIR I L+
Sbjct: 401 QNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKE 460
Query: 1080 LIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRAT---RLGTHVETVIGNGLHTA 1136
I +V L+N + +D D + ++W D Q+ I A+ ++G HV+ + + ++
Sbjct: 461 YIQLV---EQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNP 515
Query: 1137 DGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDW 1196
I +D + IYWTD +I VA LDG RK L + L P +IA+ G+++WSDW
Sbjct: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
Query: 1197 GTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRR 1256
G AKIE+A M+G +RR +V I+WPNG+ +D I+ RLYW D+K+ + S D +G DRR
Sbjct: 576 GEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRR 635
Query: 1257 TVLSNVPY---PYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQ 1313
VL ++ + P + I +YW D + +A++ A+K S+ + NL DI +
Sbjct: 636 IVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDI-IVY 694
Query: 1314 SERVL---ENACGTD--NGGCSHLCLRSPL------GYTCACPTGMPFEKSTTD 1356
E V +N C D NGGC +LCL +P YTC+CP+G E++ D
Sbjct: 695 HELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRD 748
Score = 202 bits (493), Expect = 9e-51
Identities = 123/379 (32%), Positives = 193/379 (50%), Gaps = 27/379 (7%)
Query: 1327 GGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEE-FLIFATRGSITYISLES 1385
G CS +C+ GY C C G + +T CK+ +E LIF R I I LE
Sbjct: 404 GICSQICINLKGGYKCECSRGYQMDLATG-----VCKAVGKEPSLIFTNRRDIRKIGLER 458
Query: 1386 PEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETP 1445
E + V++++NT+A+D + +F+ DL I S ++ + + + P
Sbjct: 459 KEYIQL---VEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNP 515
Query: 1446 NGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITG-LTEPRALALFPAKGYLYWSDW 1504
+ VDW+ IYWTD K I VA LDG+ RK L L EP ++A+ P G++YWSDW
Sbjct: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
Query: 1505 GEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHR- 1563
GE IE++ ++G R+ +V D+ +PNG+T+D + RLYW D+ + + DLNGQ R
Sbjct: 576 GEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRR 635
Query: 1564 --VQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAV- 1620
++ + +P +T F+D +YW D +++ A+K TG + + NL A +I
Sbjct: 636 IVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYH 695
Query: 1621 SADRQHGWNPCKE--SNGGCSHLCL----FRGH--EYICACPD----DPDHVECSTVKML 1668
+ G N C+E NGGC +LCL H +Y C+CP + + +C +
Sbjct: 696 ELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATT 755
Query: 1669 RNYRDT-ELKDEEFSNSTG 1686
Y +T + E S ++G
Sbjct: 756 VTYSETKDTNSTEISATSG 774
Score = 180 bits (438), Expect = 4e-44
Identities = 110/331 (33%), Positives = 167/331 (50%), Gaps = 46/331 (13%)
Query: 762 MDIHSRSCEET-PEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKS 820
MD+ + C+ E L++ R+D+R LE K+ I VE +++ VALD D +
Sbjct: 427 MDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQL------VEQLRNTVALDADIAA 480
Query: 821 NSIFWTDVEKDTINRAYLN---GSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIE 877
+FW D+ + I A ++ G H I N+ PA +A DW+ IYWTD + I
Sbjct: 481 QKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNPAAIAVDWVYKTIYWTDAASKTIS 538
Query: 878 VSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQ 937
V+ DG+ R L + +P I V+P G +YWSDWG IE+A M+G +R+ L+
Sbjct: 539 VATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTAD 598
Query: 938 MTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGR---TKLIENLPHPFGLDLYGDEVF 994
+ WPNG+ LDL+ +R+YW D + +L+G R K +E L HP L ++ D V+
Sbjct: 599 IQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVY 658
Query: 995 WTDWDTQSIQAANKDTGAKRRTL------------------GCGKN-------NGGCSHL 1029
W D + +++ ANK TG++ TL GKN NGGC +L
Sbjct: 659 WIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYL 718
Query: 1030 CLLKP------GGRSCACPIGIKLNKDGKTC 1054
CL P +C+CP G + ++G+ C
Sbjct: 719 CLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749
Score = 151 bits (365), Expect = 3e-35
Identities = 68/179 (37%), Positives = 100/179 (55%), Gaps = 16/179 (8%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
+C F+C N +C+ ++CDGD DC D +DE +C V +C +F CN+G+C+P RW
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC--VKKTCAESDFVCNNGQCVPSRW 89
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCA--DRRCVLKTWLCDGVRDCTNGEDEMN 379
+CD + DC DG DE + + +R C + E +C +C+ +W CDG DC +GEDE N
Sbjct: 90 KCDGDPDCEDGSDE-SPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEEN 148
Query: 380 C-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE 437
C ++C D++TC + C++R VC+G DC G DE C C A E
Sbjct: 149 CGNITCSPDEFTC---------SSGRCISRNFVCNGQDDCSDGSDELDC-APPTCGAHE 197
Score = 102 bits (244), Expect = 1e-20
Identities = 83/294 (28%), Positives = 135/294 (45%), Gaps = 15/294 (5%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVP 1078
C NNGGCSH+C G C C G +L D KTC D I+ I+L
Sbjct: 360 CLVNNGGCSHICKDLVIGYECDCAAGFEL-IDRKTCGD--IDECQNPGICSQICINLKGG 416
Query: 1079 YLIDVVLPLP-PLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTAD 1137
Y + L + V LI+ RKI + +++ V L
Sbjct: 417 YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERK--EYIQLV--EQLRNTV 472
Query: 1138 GIVIDSTGRKIYWTDGGRNSIEVAELDGR-NRKVLVWTGLDSPRAIALHYEYGYMFWSDW 1196
+ D +K++W D + +I A +D + R V + + +P AIA+ + Y ++W+D
Sbjct: 473 ALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD- 531
Query: 1197 GTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFDGHDR 1255
S I A +DG R+ + ++ ++ P +A+D + G +YW+D + IE + +G DR
Sbjct: 532 AASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDR 591
Query: 1256 R-TVLSNVPYPYGIV--IVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGL 1306
R V +++ +P GI ++ +YW D K L D N D ++ K+LE L
Sbjct: 592 RPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVD-LNGQDRRIVLKSLEFL 644
Score = 74.5 bits (175), Expect = 3e-12
Identities = 83/332 (25%), Positives = 134/332 (40%), Gaps = 23/332 (6%)
Query: 1290 KTNASDPIVIRKNLEGLMDIRAIQSERVLE---NACGTDNGGCSHLCLRSPLGYTCACPT 1346
K + + I I K D R E + E N C +NGGCSH+C +GY C C
Sbjct: 325 KCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAA 384
Query: 1347 GMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDY 1406
G T +C++ I Q D+ V +
Sbjct: 385 GFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGK----- 439
Query: 1407 HWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKV 1466
+ +IF D IR I + + + ++L L D A ++W D K
Sbjct: 440 --EPSLIFTNRRD---IRKIGLERKEYIQLV--EQLRNTVALDADIAAQKLFWADLSQKA 492
Query: 1467 IEVARLDGS-SRKV-LITGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIV 1524
I A +D R V +I + P A+A+ +YW+D I + LDG++R+ +
Sbjct: 493 IFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD-AASKTISVATLDGTKRKFLF 551
Query: 1525 QVDLGFPNGLTIDYKERRLYWTD-ALKDRIDTSDLNGQHRVQLV-PDAKNPFGMT--QFK 1580
DL P + +D +YW+D +I+ + +NG R LV D + P G+T K
Sbjct: 552 NSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIK 611
Query: 1581 DYIYWTDWYKKSIIRADKRTGKNITLIRTNLE 1612
+YW D K ++ + G++ ++ +LE
Sbjct: 612 SRLYWLD-SKLHMLSSVDLNGQDRRIVLKSLE 642
Score = 41.5 bits (93), Expect = 0.027
Identities = 19/28 (67%), Positives = 19/28 (67%), Gaps = 1/28 (3%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKT 200
CI L W CDGD DC D SDE NC V KT
Sbjct: 45 CITLLWKCDGDEDCVDGSDEKNC-VKKT 71
Score = 35.1 bits (77), Expect = 2.3
Identities = 14/31 (45%), Positives = 19/31 (61%), Gaps = 1/31 (3%)
Query: 162 ENRTICHSTNVCIALEWLCDGDNDCGDFSDE 192
E+ +C++ C+ W CDGD DC D SDE
Sbjct: 74 ESDFVCNNGQ-CVPSRWKCDGDPDCEDGSDE 103
>D16532-1|BAA03969.1| 873|Homo sapiens very low density lipoprotein
receptor protein.
Length = 873
Score = 381 bits (937), Expect = e-104
Identities = 213/625 (34%), Positives = 330/625 (52%), Gaps = 60/625 (9%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
R+C HE HST CI + W CDG+ND CD S N G+
Sbjct: 111 RTCRIHEISCGAHSTQ-CIPVSWRCDGEND---------CD---------SGEDEENCGN 151
Query: 216 VITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELM--RCAEIDFECKNT 273
+ +P + + ++ + N + S + ++ C +F+C +
Sbjct: 152 ITCSPDEFTCSSGRCI--------SRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTS 203
Query: 274 KCVPKDFQCDGDNDCGDWTDE--DSC---PMVPGSCNAGEFKCNDGKCIPERWRCDNERD 328
C+P + CD D DC D +DE + C P++ C A E +C G+CI ++WRCD + D
Sbjct: 204 SCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPD 263
Query: 329 CADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV--SC-E 385
C DG DE+NC P+ R C D++ C D C+ + C+G+RDC +G DE+NC+ C
Sbjct: 264 CKDGSDEVNC-PS--RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLG 320
Query: 386 EDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE--ERCPLKRKCSAEEKCEKLC 443
++ CR E C++ VC+ +DC DE + C + C +C
Sbjct: 321 PGKFKCRSGE---------CIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHIC 371
Query: 444 ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQTCSNTVGSFRCGCMTGYI 502
G+ C C GF L D+ +C DIDEC Q+P +CSQ C N G ++C C GY
Sbjct: 372 KDLVIGYE-CDCAAGFELI-DRKTCGDIDEC---QNPGICSQICINLKGGYKCECSRGYQ 426
Query: 503 LRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLVFWS 562
+ CK G+ P+L+F+NR IR++ L Y+ +V+ L N VALD + +FW+
Sbjct: 427 MDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWA 486
Query: 563 ENNLRVIRVAQMNTKNMSDV-IRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSK 621
+ + + I A ++ K V + + PA +AVDW++ ++WTD+ ++ + VATLDG+K
Sbjct: 487 DLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTK 546
Query: 622 RAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLT 681
R L +DL +P +IAV P V+W+DWG KIE+A M+G R+ ++ +I WPNG+T
Sbjct: 547 RKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGIT 606
Query: 682 IDYTESKIYWADAKHHVIERAAFDGRDRRKV--TTKGLPHPFALTLFDDAIYWTDWHTKS 739
+D +S++YW D+K H++ +G+DRR V + + L HP ALT+F+D +YW D ++
Sbjct: 607 LDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEA 666
Query: 740 ISTVNKNTGMGIQTVHAGLNVPMDI 764
+ NK TG + T+ LN DI
Sbjct: 667 VYGANKFTGSELATLVNNLNDAQDI 691
Score = 219 bits (535), Expect = 7e-56
Identities = 127/354 (35%), Positives = 192/354 (54%), Gaps = 24/354 (6%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGPINYLIFAHRVDIRVISLDVPY 1079
+N G CS +C+ GG C C G +++ C A G LIF +R DIR I L+
Sbjct: 401 QNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKE 460
Query: 1080 LIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRAT---RLGTHVETVIGNGLHTA 1136
I +V L+N + +D D + ++W D Q+ I A+ ++G HV+ + + ++
Sbjct: 461 YIQLV---EQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNP 515
Query: 1137 DGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDW 1196
I +D + IYWTD +I VA LDG RK L + L P +IA+ G+++WSDW
Sbjct: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
Query: 1197 GTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRR 1256
G AKIE+A M+G +RR +V I+WPNG+ +D I+ RLYW D+K+ + S D +G DRR
Sbjct: 576 GEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRR 635
Query: 1257 TVLSNVPY---PYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQ 1313
VL ++ + P + I +YW D + +A++ A+K S+ + NL DI +
Sbjct: 636 IVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDI-IVY 694
Query: 1314 SERVL---ENACGTD--NGGCSHLCLRSPL------GYTCACPTGMPFEKSTTD 1356
E V +N C D NGGC +LCL +P YTC+CP+G E++ D
Sbjct: 695 HELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRD 748
Score = 202 bits (492), Expect = 1e-50
Identities = 123/379 (32%), Positives = 193/379 (50%), Gaps = 27/379 (7%)
Query: 1327 GGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEE-FLIFATRGSITYISLES 1385
G CS +C+ GY C C G + +T CK+ +E LIF R I I LE
Sbjct: 404 GICSQICINLKGGYKCECSRGYQMDLATG-----VCKAVGKEPSLIFTNRRDIRKIGLER 458
Query: 1386 PEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETP 1445
E + V++++NT+A+D + +F+ DL I S ++ + + + P
Sbjct: 459 KEYIQL---VEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNP 515
Query: 1446 NGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITG-LTEPRALALFPAKGYLYWSDW 1504
+ VDW+ IYWTD K I VA LDG+ RK L L EP ++A+ P G++YWSDW
Sbjct: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
Query: 1505 GEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHR- 1563
GE IE++ ++G R+ +V D+ +PNG+T+D + RLYW D+ + + DLNGQ R
Sbjct: 576 GEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRR 635
Query: 1564 --VQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAV- 1620
++ + +P +T F+D +YW D +++ A+K TG + + NL A +I
Sbjct: 636 IVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYH 695
Query: 1621 SADRQHGWNPCKE--SNGGCSHLCL----FRGH--EYICACPD----DPDHVECSTVKML 1668
+ G N C+E NGGC +LCL H +Y C+CP + + +C +
Sbjct: 696 ELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATT 755
Query: 1669 RNYRDT-ELKDEEFSNSTG 1686
Y +T + E S ++G
Sbjct: 756 VTYSETKDTNTTEISATSG 774
Score = 180 bits (438), Expect = 4e-44
Identities = 110/331 (33%), Positives = 167/331 (50%), Gaps = 46/331 (13%)
Query: 762 MDIHSRSCEET-PEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKS 820
MD+ + C+ E L++ R+D+R LE K+ I VE +++ VALD D +
Sbjct: 427 MDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQL------VEQLRNTVALDADIAA 480
Query: 821 NSIFWTDVEKDTINRAYLN---GSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIE 877
+FW D+ + I A ++ G H I N+ PA +A DW+ IYWTD + I
Sbjct: 481 QKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNPAAIAVDWVYKTIYWTDAASKTIS 538
Query: 878 VSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQ 937
V+ DG+ R L + +P I V+P G +YWSDWG IE+A M+G +R+ L+
Sbjct: 539 VATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTAD 598
Query: 938 MTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGR---TKLIENLPHPFGLDLYGDEVF 994
+ WPNG+ LDL+ +R+YW D + +L+G R K +E L HP L ++ D V+
Sbjct: 599 IQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVY 658
Query: 995 WTDWDTQSIQAANKDTGAKRRTL------------------GCGKN-------NGGCSHL 1029
W D + +++ ANK TG++ TL GKN NGGC +L
Sbjct: 659 WIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYL 718
Query: 1030 CLLKP------GGRSCACPIGIKLNKDGKTC 1054
CL P +C+CP G + ++G+ C
Sbjct: 719 CLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749
Score = 151 bits (365), Expect = 3e-35
Identities = 68/179 (37%), Positives = 100/179 (55%), Gaps = 16/179 (8%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
+C F+C N +C+ ++CDGD DC D +DE +C V +C +F CN+G+C+P RW
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC--VKKTCAESDFVCNNGQCVPSRW 89
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCA--DRRCVLKTWLCDGVRDCTNGEDEMN 379
+CD + DC DG DE + + +R C + E +C +C+ +W CDG DC +GEDE N
Sbjct: 90 KCDGDPDCEDGSDE-SPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEEN 148
Query: 380 C-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE 437
C ++C D++TC + C++R VC+G DC G DE C C A E
Sbjct: 149 CGNITCSPDEFTC---------SSGRCISRNFVCNGQDDCSDGSDELDC-APPTCGAHE 197
Score = 102 bits (244), Expect = 1e-20
Identities = 83/294 (28%), Positives = 135/294 (45%), Gaps = 15/294 (5%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVP 1078
C NNGGCSH+C G C C G +L D KTC D I+ I+L
Sbjct: 360 CLVNNGGCSHICKDLVIGYECDCAAGFEL-IDRKTCGD--IDECQNPGICSQICINLKGG 416
Query: 1079 YLIDVVLPLP-PLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTAD 1137
Y + L + V LI+ RKI + +++ V L
Sbjct: 417 YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERK--EYIQLV--EQLRNTV 472
Query: 1138 GIVIDSTGRKIYWTDGGRNSIEVAELDGR-NRKVLVWTGLDSPRAIALHYEYGYMFWSDW 1196
+ D +K++W D + +I A +D + R V + + +P AIA+ + Y ++W+D
Sbjct: 473 ALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD- 531
Query: 1197 GTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFDGHDR 1255
S I A +DG R+ + ++ ++ P +A+D + G +YW+D + IE + +G DR
Sbjct: 532 AASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDR 591
Query: 1256 R-TVLSNVPYPYGIV--IVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGL 1306
R V +++ +P GI ++ +YW D K L D N D ++ K+LE L
Sbjct: 592 RPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVD-LNGQDRRIVLKSLEFL 644
Score = 74.5 bits (175), Expect = 3e-12
Identities = 83/332 (25%), Positives = 134/332 (40%), Gaps = 23/332 (6%)
Query: 1290 KTNASDPIVIRKNLEGLMDIRAIQSERVLE---NACGTDNGGCSHLCLRSPLGYTCACPT 1346
K + + I I K D R E + E N C +NGGCSH+C +GY C C
Sbjct: 325 KCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAA 384
Query: 1347 GMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDY 1406
G T +C++ I Q D+ V +
Sbjct: 385 GFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGK----- 439
Query: 1407 HWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKV 1466
+ +IF D IR I + + + ++L L D A ++W D K
Sbjct: 440 --EPSLIFTNRRD---IRKIGLERKEYIQLV--EQLRNTVALDADIAAQKLFWADLSQKA 492
Query: 1467 IEVARLDGS-SRKV-LITGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIV 1524
I A +D R V +I + P A+A+ +YW+D I + LDG++R+ +
Sbjct: 493 IFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD-AASKTISVATLDGTKRKFLF 551
Query: 1525 QVDLGFPNGLTIDYKERRLYWTD-ALKDRIDTSDLNGQHRVQLV-PDAKNPFGMT--QFK 1580
DL P + +D +YW+D +I+ + +NG R LV D + P G+T K
Sbjct: 552 NSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIK 611
Query: 1581 DYIYWTDWYKKSIIRADKRTGKNITLIRTNLE 1612
+YW D K ++ + G++ ++ +LE
Sbjct: 612 SRLYWLD-SKLHMLSSVDLNGQDRRIVLKSLE 642
Score = 41.5 bits (93), Expect = 0.027
Identities = 19/28 (67%), Positives = 19/28 (67%), Gaps = 1/28 (3%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKT 200
CI L W CDGD DC D SDE NC V KT
Sbjct: 45 CITLLWKCDGDEDCVDGSDEKNC-VKKT 71
Score = 35.1 bits (77), Expect = 2.3
Identities = 14/31 (45%), Positives = 19/31 (61%), Gaps = 1/31 (3%)
Query: 162 ENRTICHSTNVCIALEWLCDGDNDCGDFSDE 192
E+ +C++ C+ W CDGD DC D SDE
Sbjct: 74 ESDFVCNNGQ-CVPSRWKCDGDPDCEDGSDE 103
>D16494-1|BAA03946.1| 845|Homo sapiens very low density lipoprotein
receptor protein.
Length = 845
Score = 381 bits (937), Expect = e-104
Identities = 213/625 (34%), Positives = 330/625 (52%), Gaps = 60/625 (9%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
R+C HE HST CI + W CDG+ND CD S N G+
Sbjct: 111 RTCRIHEISCGAHSTQ-CIPVSWRCDGEND---------CD---------SGEDEENCGN 151
Query: 216 VITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELM--RCAEIDFECKNT 273
+ +P + + ++ + N + S + ++ C +F+C +
Sbjct: 152 ITCSPDEFTCSSGRCI--------SRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTS 203
Query: 274 KCVPKDFQCDGDNDCGDWTDE--DSC---PMVPGSCNAGEFKCNDGKCIPERWRCDNERD 328
C+P + CD D DC D +DE + C P++ C A E +C G+CI ++WRCD + D
Sbjct: 204 SCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPD 263
Query: 329 CADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV--SC-E 385
C DG DE+NC P+ R C D++ C D C+ + C+G+RDC +G DE+NC+ C
Sbjct: 264 CKDGSDEVNC-PS--RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLG 320
Query: 386 EDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE--ERCPLKRKCSAEEKCEKLC 443
++ CR E C++ VC+ +DC DE + C + C +C
Sbjct: 321 PGKFKCRSGE---------CIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHIC 371
Query: 444 ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQTCSNTVGSFRCGCMTGYI 502
G+ C C GF L D+ +C DIDEC Q+P +CSQ C N G ++C C GY
Sbjct: 372 KDLVIGYE-CDCAAGFELI-DRKTCGDIDEC---QNPGICSQICINLKGGYKCECSRGYQ 426
Query: 503 LRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLVFWS 562
+ CK G+ P+L+F+NR IR++ L Y+ +V+ L N VALD + +FW+
Sbjct: 427 MDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWA 486
Query: 563 ENNLRVIRVAQMNTKNMSDV-IRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSK 621
+ + + I A ++ K V + + PA +AVDW++ ++WTD+ ++ + VATLDG+K
Sbjct: 487 DLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTK 546
Query: 622 RAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLT 681
R L +DL +P +IAV P V+W+DWG KIE+A M+G R+ ++ +I WPNG+T
Sbjct: 547 RKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGIT 606
Query: 682 IDYTESKIYWADAKHHVIERAAFDGRDRRKV--TTKGLPHPFALTLFDDAIYWTDWHTKS 739
+D +S++YW D+K H++ +G+DRR V + + L HP ALT+F+D +YW D ++
Sbjct: 607 LDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEA 666
Query: 740 ISTVNKNTGMGIQTVHAGLNVPMDI 764
+ NK TG + T+ LN DI
Sbjct: 667 VYGANKFTGSELATLVNNLNDAQDI 691
Score = 219 bits (535), Expect = 7e-56
Identities = 127/354 (35%), Positives = 192/354 (54%), Gaps = 24/354 (6%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGPINYLIFAHRVDIRVISLDVPY 1079
+N G CS +C+ GG C C G +++ C A G LIF +R DIR I L+
Sbjct: 401 QNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKE 460
Query: 1080 LIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRAT---RLGTHVETVIGNGLHTA 1136
I +V L+N + +D D + ++W D Q+ I A+ ++G HV+ + + ++
Sbjct: 461 YIQLV---EQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNP 515
Query: 1137 DGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDW 1196
I +D + IYWTD +I VA LDG RK L + L P +IA+ G+++WSDW
Sbjct: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
Query: 1197 GTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRR 1256
G AKIE+A M+G +RR +V I+WPNG+ +D I+ RLYW D+K+ + S D +G DRR
Sbjct: 576 GEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRR 635
Query: 1257 TVLSNVPY---PYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQ 1313
VL ++ + P + I +YW D + +A++ A+K S+ + NL DI +
Sbjct: 636 IVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDI-IVY 694
Query: 1314 SERVL---ENACGTD--NGGCSHLCLRSPL------GYTCACPTGMPFEKSTTD 1356
E V +N C D NGGC +LCL +P YTC+CP+G E++ D
Sbjct: 695 HELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRD 748
Score = 201 bits (490), Expect = 2e-50
Identities = 117/342 (34%), Positives = 179/342 (52%), Gaps = 22/342 (6%)
Query: 1327 GGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEE-FLIFATRGSITYISLES 1385
G CS +C+ GY C C G + +T CK+ +E LIF R I I LE
Sbjct: 404 GICSQICINLKGGYKCECSRGYQMDLATG-----VCKAVGKEPSLIFTNRRDIRKIGLER 458
Query: 1386 PEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETP 1445
E + V++++NT+A+D + +F+ DL I S ++ + + + P
Sbjct: 459 KEYIQL---VEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNP 515
Query: 1446 NGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITG-LTEPRALALFPAKGYLYWSDW 1504
+ VDW+ IYWTD K I VA LDG+ RK L L EP ++A+ P G++YWSDW
Sbjct: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
Query: 1505 GEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHR- 1563
GE IE++ ++G R+ +V D+ +PNG+T+D + RLYW D+ + + DLNGQ R
Sbjct: 576 GEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRR 635
Query: 1564 --VQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAV- 1620
++ + +P +T F+D +YW D +++ A+K TG + + NL A +I
Sbjct: 636 IVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYH 695
Query: 1621 SADRQHGWNPCKE--SNGGCSHLCL----FRGH--EYICACP 1654
+ G N C+E NGGC +LCL H +Y C+CP
Sbjct: 696 ELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCP 737
Score = 180 bits (438), Expect = 4e-44
Identities = 110/331 (33%), Positives = 167/331 (50%), Gaps = 46/331 (13%)
Query: 762 MDIHSRSCEET-PEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKS 820
MD+ + C+ E L++ R+D+R LE K+ I VE +++ VALD D +
Sbjct: 427 MDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQL------VEQLRNTVALDADIAA 480
Query: 821 NSIFWTDVEKDTINRAYLN---GSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIE 877
+FW D+ + I A ++ G H I N+ PA +A DW+ IYWTD + I
Sbjct: 481 QKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNPAAIAVDWVYKTIYWTDAASKTIS 538
Query: 878 VSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQ 937
V+ DG+ R L + +P I V+P G +YWSDWG IE+A M+G +R+ L+
Sbjct: 539 VATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTAD 598
Query: 938 MTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGR---TKLIENLPHPFGLDLYGDEVF 994
+ WPNG+ LDL+ +R+YW D + +L+G R K +E L HP L ++ D V+
Sbjct: 599 IQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVY 658
Query: 995 WTDWDTQSIQAANKDTGAKRRTL------------------GCGKN-------NGGCSHL 1029
W D + +++ ANK TG++ TL GKN NGGC +L
Sbjct: 659 WIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYL 718
Query: 1030 CLLKP------GGRSCACPIGIKLNKDGKTC 1054
CL P +C+CP G + ++G+ C
Sbjct: 719 CLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749
Score = 151 bits (365), Expect = 3e-35
Identities = 68/179 (37%), Positives = 100/179 (55%), Gaps = 16/179 (8%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
+C F+C N +C+ ++CDGD DC D +DE +C V +C +F CN+G+C+P RW
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC--VKKTCAESDFVCNNGQCVPSRW 89
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCA--DRRCVLKTWLCDGVRDCTNGEDEMN 379
+CD + DC DG DE + + +R C + E +C +C+ +W CDG DC +GEDE N
Sbjct: 90 KCDGDPDCEDGSDE-SPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEEN 148
Query: 380 C-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE 437
C ++C D++TC + C++R VC+G DC G DE C C A E
Sbjct: 149 CGNITCSPDEFTC---------SSGRCISRNFVCNGQDDCSDGSDELDC-APPTCGAHE 197
Score = 102 bits (244), Expect = 1e-20
Identities = 83/294 (28%), Positives = 135/294 (45%), Gaps = 15/294 (5%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVP 1078
C NNGGCSH+C G C C G +L D KTC D I+ I+L
Sbjct: 360 CLVNNGGCSHICKDLVIGYECDCAAGFEL-IDRKTCGD--IDECQNPGICSQICINLKGG 416
Query: 1079 YLIDVVLPLP-PLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTAD 1137
Y + L + V LI+ RKI + +++ V L
Sbjct: 417 YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERK--EYIQLV--EQLRNTV 472
Query: 1138 GIVIDSTGRKIYWTDGGRNSIEVAELDGR-NRKVLVWTGLDSPRAIALHYEYGYMFWSDW 1196
+ D +K++W D + +I A +D + R V + + +P AIA+ + Y ++W+D
Sbjct: 473 ALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD- 531
Query: 1197 GTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFDGHDR 1255
S I A +DG R+ + ++ ++ P +A+D + G +YW+D + IE + +G DR
Sbjct: 532 AASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDR 591
Query: 1256 R-TVLSNVPYPYGIV--IVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGL 1306
R V +++ +P GI ++ +YW D K L D N D ++ K+LE L
Sbjct: 592 RPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVD-LNGQDRRIVLKSLEFL 644
Score = 74.5 bits (175), Expect = 3e-12
Identities = 83/332 (25%), Positives = 134/332 (40%), Gaps = 23/332 (6%)
Query: 1290 KTNASDPIVIRKNLEGLMDIRAIQSERVLE---NACGTDNGGCSHLCLRSPLGYTCACPT 1346
K + + I I K D R E + E N C +NGGCSH+C +GY C C
Sbjct: 325 KCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAA 384
Query: 1347 GMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDY 1406
G T +C++ I Q D+ V +
Sbjct: 385 GFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGK----- 439
Query: 1407 HWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKV 1466
+ +IF D IR I + + + ++L L D A ++W D K
Sbjct: 440 --EPSLIFTNRRD---IRKIGLERKEYIQLV--EQLRNTVALDADIAAQKLFWADLSQKA 492
Query: 1467 IEVARLDGS-SRKV-LITGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIV 1524
I A +D R V +I + P A+A+ +YW+D I + LDG++R+ +
Sbjct: 493 IFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD-AASKTISVATLDGTKRKFLF 551
Query: 1525 QVDLGFPNGLTIDYKERRLYWTD-ALKDRIDTSDLNGQHRVQLV-PDAKNPFGMT--QFK 1580
DL P + +D +YW+D +I+ + +NG R LV D + P G+T K
Sbjct: 552 NSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIK 611
Query: 1581 DYIYWTDWYKKSIIRADKRTGKNITLIRTNLE 1612
+YW D K ++ + G++ ++ +LE
Sbjct: 612 SRLYWLD-SKLHMLSSVDLNGQDRRIVLKSLE 642
Score = 41.5 bits (93), Expect = 0.027
Identities = 19/28 (67%), Positives = 19/28 (67%), Gaps = 1/28 (3%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKT 200
CI L W CDGD DC D SDE NC V KT
Sbjct: 45 CITLLWKCDGDEDCVDGSDEKNC-VKKT 71
Score = 35.1 bits (77), Expect = 2.3
Identities = 14/31 (45%), Positives = 19/31 (61%), Gaps = 1/31 (3%)
Query: 162 ENRTICHSTNVCIALEWLCDGDNDCGDFSDE 192
E+ +C++ C+ W CDGD DC D SDE
Sbjct: 74 ESDFVCNNGQ-CVPSRWKCDGDPDCEDGSDE 103
>D16493-1|BAA03945.1| 873|Homo sapiens very low density lipoprotein
receptor protein.
Length = 873
Score = 381 bits (937), Expect = e-104
Identities = 213/625 (34%), Positives = 330/625 (52%), Gaps = 60/625 (9%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
R+C HE HST CI + W CDG+ND CD S N G+
Sbjct: 111 RTCRIHEISCGAHSTQ-CIPVSWRCDGEND---------CD---------SGEDEENCGN 151
Query: 216 VITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELM--RCAEIDFECKNT 273
+ +P + + ++ + N + S + ++ C +F+C +
Sbjct: 152 ITCSPDEFTCSSGRCI--------SRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTS 203
Query: 274 KCVPKDFQCDGDNDCGDWTDE--DSC---PMVPGSCNAGEFKCNDGKCIPERWRCDNERD 328
C+P + CD D DC D +DE + C P++ C A E +C G+CI ++WRCD + D
Sbjct: 204 SCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPD 263
Query: 329 CADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV--SC-E 385
C DG DE+NC P+ R C D++ C D C+ + C+G+RDC +G DE+NC+ C
Sbjct: 264 CKDGSDEVNC-PS--RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLG 320
Query: 386 EDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE--ERCPLKRKCSAEEKCEKLC 443
++ CR E C++ VC+ +DC DE + C + C +C
Sbjct: 321 PGKFKCRSGE---------CIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHIC 371
Query: 444 ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQTCSNTVGSFRCGCMTGYI 502
G+ C C GF L D+ +C DIDEC Q+P +CSQ C N G ++C C GY
Sbjct: 372 KDLVIGYE-CDCAAGFELI-DRKTCGDIDEC---QNPGICSQICINLKGGYKCECSRGYQ 426
Query: 503 LRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLVFWS 562
+ CK G+ P+L+F+NR IR++ L Y+ +V+ L N VALD + +FW+
Sbjct: 427 MDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWA 486
Query: 563 ENNLRVIRVAQMNTKNMSDV-IRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSK 621
+ + + I A ++ K V + + PA +AVDW++ ++WTD+ ++ + VATLDG+K
Sbjct: 487 DLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTK 546
Query: 622 RAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLT 681
R L +DL +P +IAV P V+W+DWG KIE+A M+G R+ ++ +I WPNG+T
Sbjct: 547 RKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGIT 606
Query: 682 IDYTESKIYWADAKHHVIERAAFDGRDRRKV--TTKGLPHPFALTLFDDAIYWTDWHTKS 739
+D +S++YW D+K H++ +G+DRR V + + L HP ALT+F+D +YW D ++
Sbjct: 607 LDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEA 666
Query: 740 ISTVNKNTGMGIQTVHAGLNVPMDI 764
+ NK TG + T+ LN DI
Sbjct: 667 VYGANKFTGSELATLVNNLNDAQDI 691
Score = 219 bits (535), Expect = 7e-56
Identities = 127/354 (35%), Positives = 192/354 (54%), Gaps = 24/354 (6%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGPINYLIFAHRVDIRVISLDVPY 1079
+N G CS +C+ GG C C G +++ C A G LIF +R DIR I L+
Sbjct: 401 QNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKE 460
Query: 1080 LIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRAT---RLGTHVETVIGNGLHTA 1136
I +V L+N + +D D + ++W D Q+ I A+ ++G HV+ + + ++
Sbjct: 461 YIQLV---EQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNP 515
Query: 1137 DGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDW 1196
I +D + IYWTD +I VA LDG RK L + L P +IA+ G+++WSDW
Sbjct: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
Query: 1197 GTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRR 1256
G AKIE+A M+G +RR +V I+WPNG+ +D I+ RLYW D+K+ + S D +G DRR
Sbjct: 576 GEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRR 635
Query: 1257 TVLSNVPY---PYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQ 1313
VL ++ + P + I +YW D + +A++ A+K S+ + NL DI +
Sbjct: 636 IVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDI-IVY 694
Query: 1314 SERVL---ENACGTD--NGGCSHLCLRSPL------GYTCACPTGMPFEKSTTD 1356
E V +N C D NGGC +LCL +P YTC+CP+G E++ D
Sbjct: 695 HELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRD 748
Score = 202 bits (492), Expect = 1e-50
Identities = 123/379 (32%), Positives = 193/379 (50%), Gaps = 27/379 (7%)
Query: 1327 GGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEE-FLIFATRGSITYISLES 1385
G CS +C+ GY C C G + +T CK+ +E LIF R I I LE
Sbjct: 404 GICSQICINLKGGYKCECSRGYQMDLATG-----VCKAVGKEPSLIFTNRRDIRKIGLER 458
Query: 1386 PEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETP 1445
E + V++++NT+A+D + +F+ DL I S ++ + + + P
Sbjct: 459 KEYIQL---VEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNP 515
Query: 1446 NGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITG-LTEPRALALFPAKGYLYWSDW 1504
+ VDW+ IYWTD K I VA LDG+ RK L L EP ++A+ P G++YWSDW
Sbjct: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
Query: 1505 GEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHR- 1563
GE IE++ ++G R+ +V D+ +PNG+T+D + RLYW D+ + + DLNGQ R
Sbjct: 576 GEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRR 635
Query: 1564 --VQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAV- 1620
++ + +P +T F+D +YW D +++ A+K TG + + NL A +I
Sbjct: 636 IVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYH 695
Query: 1621 SADRQHGWNPCKE--SNGGCSHLCL----FRGH--EYICACPD----DPDHVECSTVKML 1668
+ G N C+E NGGC +LCL H +Y C+CP + + +C +
Sbjct: 696 ELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATT 755
Query: 1669 RNYRDT-ELKDEEFSNSTG 1686
Y +T + E S ++G
Sbjct: 756 VTYSETKDTNTTEISATSG 774
Score = 180 bits (438), Expect = 4e-44
Identities = 110/331 (33%), Positives = 167/331 (50%), Gaps = 46/331 (13%)
Query: 762 MDIHSRSCEET-PEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKS 820
MD+ + C+ E L++ R+D+R LE K+ I VE +++ VALD D +
Sbjct: 427 MDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQL------VEQLRNTVALDADIAA 480
Query: 821 NSIFWTDVEKDTINRAYLN---GSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIE 877
+FW D+ + I A ++ G H I N+ PA +A DW+ IYWTD + I
Sbjct: 481 QKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNPAAIAVDWVYKTIYWTDAASKTIS 538
Query: 878 VSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQ 937
V+ DG+ R L + +P I V+P G +YWSDWG IE+A M+G +R+ L+
Sbjct: 539 VATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTAD 598
Query: 938 MTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGR---TKLIENLPHPFGLDLYGDEVF 994
+ WPNG+ LDL+ +R+YW D + +L+G R K +E L HP L ++ D V+
Sbjct: 599 IQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVY 658
Query: 995 WTDWDTQSIQAANKDTGAKRRTL------------------GCGKN-------NGGCSHL 1029
W D + +++ ANK TG++ TL GKN NGGC +L
Sbjct: 659 WIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYL 718
Query: 1030 CLLKP------GGRSCACPIGIKLNKDGKTC 1054
CL P +C+CP G + ++G+ C
Sbjct: 719 CLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749
Score = 151 bits (365), Expect = 3e-35
Identities = 68/179 (37%), Positives = 100/179 (55%), Gaps = 16/179 (8%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
+C F+C N +C+ ++CDGD DC D +DE +C V +C +F CN+G+C+P RW
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC--VKKTCAESDFVCNNGQCVPSRW 89
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCA--DRRCVLKTWLCDGVRDCTNGEDEMN 379
+CD + DC DG DE + + +R C + E +C +C+ +W CDG DC +GEDE N
Sbjct: 90 KCDGDPDCEDGSDE-SPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEEN 148
Query: 380 C-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE 437
C ++C D++TC + C++R VC+G DC G DE C C A E
Sbjct: 149 CGNITCSPDEFTC---------SSGRCISRNFVCNGQDDCSDGSDELDC-APPTCGAHE 197
Score = 102 bits (244), Expect = 1e-20
Identities = 83/294 (28%), Positives = 135/294 (45%), Gaps = 15/294 (5%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVP 1078
C NNGGCSH+C G C C G +L D KTC D I+ I+L
Sbjct: 360 CLVNNGGCSHICKDLVIGYECDCAAGFEL-IDRKTCGD--IDECQNPGICSQICINLKGG 416
Query: 1079 YLIDVVLPLP-PLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTAD 1137
Y + L + V LI+ RKI + +++ V L
Sbjct: 417 YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERK--EYIQLV--EQLRNTV 472
Query: 1138 GIVIDSTGRKIYWTDGGRNSIEVAELDGR-NRKVLVWTGLDSPRAIALHYEYGYMFWSDW 1196
+ D +K++W D + +I A +D + R V + + +P AIA+ + Y ++W+D
Sbjct: 473 ALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD- 531
Query: 1197 GTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFDGHDR 1255
S I A +DG R+ + ++ ++ P +A+D + G +YW+D + IE + +G DR
Sbjct: 532 AASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDR 591
Query: 1256 R-TVLSNVPYPYGIV--IVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGL 1306
R V +++ +P GI ++ +YW D K L D N D ++ K+LE L
Sbjct: 592 RPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVD-LNGQDRRIVLKSLEFL 644
Score = 74.5 bits (175), Expect = 3e-12
Identities = 83/332 (25%), Positives = 134/332 (40%), Gaps = 23/332 (6%)
Query: 1290 KTNASDPIVIRKNLEGLMDIRAIQSERVLE---NACGTDNGGCSHLCLRSPLGYTCACPT 1346
K + + I I K D R E + E N C +NGGCSH+C +GY C C
Sbjct: 325 KCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAA 384
Query: 1347 GMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDY 1406
G T +C++ I Q D+ V +
Sbjct: 385 GFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGK----- 439
Query: 1407 HWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKV 1466
+ +IF D IR I + + + ++L L D A ++W D K
Sbjct: 440 --EPSLIFTNRRD---IRKIGLERKEYIQLV--EQLRNTVALDADIAAQKLFWADLSQKA 492
Query: 1467 IEVARLDGS-SRKV-LITGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIV 1524
I A +D R V +I + P A+A+ +YW+D I + LDG++R+ +
Sbjct: 493 IFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD-AASKTISVATLDGTKRKFLF 551
Query: 1525 QVDLGFPNGLTIDYKERRLYWTD-ALKDRIDTSDLNGQHRVQLV-PDAKNPFGMT--QFK 1580
DL P + +D +YW+D +I+ + +NG R LV D + P G+T K
Sbjct: 552 NSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIK 611
Query: 1581 DYIYWTDWYKKSIIRADKRTGKNITLIRTNLE 1612
+YW D K ++ + G++ ++ +LE
Sbjct: 612 SRLYWLD-SKLHMLSSVDLNGQDRRIVLKSLE 642
Score = 41.5 bits (93), Expect = 0.027
Identities = 19/28 (67%), Positives = 19/28 (67%), Gaps = 1/28 (3%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKT 200
CI L W CDGD DC D SDE NC V KT
Sbjct: 45 CITLLWKCDGDEDCVDGSDEKNC-VKKT 71
Score = 35.1 bits (77), Expect = 2.3
Identities = 14/31 (45%), Positives = 19/31 (61%), Gaps = 1/31 (3%)
Query: 162 ENRTICHSTNVCIALEWLCDGDNDCGDFSDE 192
E+ +C++ C+ W CDGD DC D SDE
Sbjct: 74 ESDFVCNNGQ-CVPSRWKCDGDPDCEDGSDE 103
>DQ067198-1|AAY46157.1| 873|Homo sapiens very low density
lipoprotein receptor protein.
Length = 873
Score = 381 bits (937), Expect = e-104
Identities = 213/625 (34%), Positives = 330/625 (52%), Gaps = 60/625 (9%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
R+C HE HST CI + W CDG+ND CD S N G+
Sbjct: 111 RTCRIHEISCGAHSTQ-CIPVSWRCDGEND---------CD---------SGEDEENCGN 151
Query: 216 VITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELM--RCAEIDFECKNT 273
+ +P + + ++ + N + S + ++ C +F+C +
Sbjct: 152 ITCSPDEFTCSSGRCI--------SRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTS 203
Query: 274 KCVPKDFQCDGDNDCGDWTDE--DSC---PMVPGSCNAGEFKCNDGKCIPERWRCDNERD 328
C+P + CD D DC D +DE + C P++ C A E +C G+CI ++WRCD + D
Sbjct: 204 SCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPD 263
Query: 329 CADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV--SC-E 385
C DG DE+NC P+ R C D++ C D C+ + C+G+RDC +G DE+NC+ C
Sbjct: 264 CKDGSDEVNC-PS--RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLG 320
Query: 386 EDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE--ERCPLKRKCSAEEKCEKLC 443
++ CR E C++ VC+ +DC DE + C + C +C
Sbjct: 321 PGKFKCRSGE---------CIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHIC 371
Query: 444 ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQTCSNTVGSFRCGCMTGYI 502
G+ C C GF L D+ +C DIDEC Q+P +CSQ C N G ++C C GY
Sbjct: 372 KDLVIGYE-CDCAAGFELI-DRKTCGDIDEC---QNPGICSQICINLKGGYKCECSRGYQ 426
Query: 503 LRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLVFWS 562
+ CK G+ P+L+F+NR IR++ L Y+ +V+ L N VALD + +FW+
Sbjct: 427 MDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWA 486
Query: 563 ENNLRVIRVAQMNTKNMSDV-IRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSK 621
+ + + I A ++ K V + + PA +AVDW++ ++WTD+ ++ + VATLDG+K
Sbjct: 487 DLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTK 546
Query: 622 RAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLT 681
R L +DL +P +IAV P V+W+DWG KIE+A M+G R+ ++ +I WPNG+T
Sbjct: 547 RKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGIT 606
Query: 682 IDYTESKIYWADAKHHVIERAAFDGRDRRKV--TTKGLPHPFALTLFDDAIYWTDWHTKS 739
+D +S++YW D+K H++ +G+DRR V + + L HP ALT+F+D +YW D ++
Sbjct: 607 LDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEA 666
Query: 740 ISTVNKNTGMGIQTVHAGLNVPMDI 764
+ NK TG + T+ LN DI
Sbjct: 667 VYGANKFTGSELATLVNNLNDAQDI 691
Score = 219 bits (535), Expect = 7e-56
Identities = 127/354 (35%), Positives = 192/354 (54%), Gaps = 24/354 (6%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGPINYLIFAHRVDIRVISLDVPY 1079
+N G CS +C+ GG C C G +++ C A G LIF +R DIR I L+
Sbjct: 401 QNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKE 460
Query: 1080 LIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRAT---RLGTHVETVIGNGLHTA 1136
I +V L+N + +D D + ++W D Q+ I A+ ++G HV+ + + ++
Sbjct: 461 YIQLV---EQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNP 515
Query: 1137 DGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDW 1196
I +D + IYWTD +I VA LDG RK L + L P +IA+ G+++WSDW
Sbjct: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
Query: 1197 GTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRR 1256
G AKIE+A M+G +RR +V I+WPNG+ +D I+ RLYW D+K+ + S D +G DRR
Sbjct: 576 GEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRR 635
Query: 1257 TVLSNVPY---PYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQ 1313
VL ++ + P + I +YW D + +A++ A+K S+ + NL DI +
Sbjct: 636 IVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDI-IVY 694
Query: 1314 SERVL---ENACGTD--NGGCSHLCLRSPL------GYTCACPTGMPFEKSTTD 1356
E V +N C D NGGC +LCL +P YTC+CP+G E++ D
Sbjct: 695 HELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRD 748
Score = 202 bits (492), Expect = 1e-50
Identities = 123/379 (32%), Positives = 193/379 (50%), Gaps = 27/379 (7%)
Query: 1327 GGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEE-FLIFATRGSITYISLES 1385
G CS +C+ GY C C G + +T CK+ +E LIF R I I LE
Sbjct: 404 GICSQICINLKGGYKCECSRGYQMDLATG-----VCKAVGKEPSLIFTNRRDIRKIGLER 458
Query: 1386 PEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETP 1445
E + V++++NT+A+D + +F+ DL I S ++ + + + P
Sbjct: 459 KEYIQL---VEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNP 515
Query: 1446 NGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITG-LTEPRALALFPAKGYLYWSDW 1504
+ VDW+ IYWTD K I VA LDG+ RK L L EP ++A+ P G++YWSDW
Sbjct: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
Query: 1505 GEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHR- 1563
GE IE++ ++G R+ +V D+ +PNG+T+D + RLYW D+ + + DLNGQ R
Sbjct: 576 GEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRR 635
Query: 1564 --VQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAV- 1620
++ + +P +T F+D +YW D +++ A+K TG + + NL A +I
Sbjct: 636 IVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYH 695
Query: 1621 SADRQHGWNPCKE--SNGGCSHLCL----FRGH--EYICACPD----DPDHVECSTVKML 1668
+ G N C+E NGGC +LCL H +Y C+CP + + +C +
Sbjct: 696 ELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATT 755
Query: 1669 RNYRDT-ELKDEEFSNSTG 1686
Y +T + E S ++G
Sbjct: 756 VTYSETKDTNTTEISATSG 774
Score = 180 bits (438), Expect = 4e-44
Identities = 110/331 (33%), Positives = 167/331 (50%), Gaps = 46/331 (13%)
Query: 762 MDIHSRSCEET-PEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKS 820
MD+ + C+ E L++ R+D+R LE K+ I VE +++ VALD D +
Sbjct: 427 MDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQL------VEQLRNTVALDADIAA 480
Query: 821 NSIFWTDVEKDTINRAYLN---GSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIE 877
+FW D+ + I A ++ G H I N+ PA +A DW+ IYWTD + I
Sbjct: 481 QKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNPAAIAVDWVYKTIYWTDAASKTIS 538
Query: 878 VSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQ 937
V+ DG+ R L + +P I V+P G +YWSDWG IE+A M+G +R+ L+
Sbjct: 539 VATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTAD 598
Query: 938 MTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGR---TKLIENLPHPFGLDLYGDEVF 994
+ WPNG+ LDL+ +R+YW D + +L+G R K +E L HP L ++ D V+
Sbjct: 599 IQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVY 658
Query: 995 WTDWDTQSIQAANKDTGAKRRTL------------------GCGKN-------NGGCSHL 1029
W D + +++ ANK TG++ TL GKN NGGC +L
Sbjct: 659 WIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYL 718
Query: 1030 CLLKP------GGRSCACPIGIKLNKDGKTC 1054
CL P +C+CP G + ++G+ C
Sbjct: 719 CLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749
Score = 151 bits (365), Expect = 3e-35
Identities = 68/179 (37%), Positives = 100/179 (55%), Gaps = 16/179 (8%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
+C F+C N +C+ ++CDGD DC D +DE +C V +C +F CN+G+C+P RW
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC--VKKTCAESDFVCNNGQCVPSRW 89
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCA--DRRCVLKTWLCDGVRDCTNGEDEMN 379
+CD + DC DG DE + + +R C + E +C +C+ +W CDG DC +GEDE N
Sbjct: 90 KCDGDPDCEDGSDE-SPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEEN 148
Query: 380 C-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE 437
C ++C D++TC + C++R VC+G DC G DE C C A E
Sbjct: 149 CGNITCSPDEFTC---------SSGRCISRNFVCNGQDDCSDGSDELDC-APPTCGAHE 197
Score = 102 bits (244), Expect = 1e-20
Identities = 83/294 (28%), Positives = 135/294 (45%), Gaps = 15/294 (5%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVP 1078
C NNGGCSH+C G C C G +L D KTC D I+ I+L
Sbjct: 360 CLVNNGGCSHICKDLVIGYECDCAAGFEL-IDRKTCGD--IDECQNPGICSQICINLKGG 416
Query: 1079 YLIDVVLPLP-PLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTAD 1137
Y + L + V LI+ RKI + +++ V L
Sbjct: 417 YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERK--EYIQLV--EQLRNTV 472
Query: 1138 GIVIDSTGRKIYWTDGGRNSIEVAELDGR-NRKVLVWTGLDSPRAIALHYEYGYMFWSDW 1196
+ D +K++W D + +I A +D + R V + + +P AIA+ + Y ++W+D
Sbjct: 473 ALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD- 531
Query: 1197 GTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFDGHDR 1255
S I A +DG R+ + ++ ++ P +A+D + G +YW+D + IE + +G DR
Sbjct: 532 AASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDR 591
Query: 1256 R-TVLSNVPYPYGIV--IVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGL 1306
R V +++ +P GI ++ +YW D K L D N D ++ K+LE L
Sbjct: 592 RPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVD-LNGQDRRIVLKSLEFL 644
Score = 74.5 bits (175), Expect = 3e-12
Identities = 83/332 (25%), Positives = 134/332 (40%), Gaps = 23/332 (6%)
Query: 1290 KTNASDPIVIRKNLEGLMDIRAIQSERVLE---NACGTDNGGCSHLCLRSPLGYTCACPT 1346
K + + I I K D R E + E N C +NGGCSH+C +GY C C
Sbjct: 325 KCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAA 384
Query: 1347 GMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDY 1406
G T +C++ I Q D+ V +
Sbjct: 385 GFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGK----- 439
Query: 1407 HWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKV 1466
+ +IF D IR I + + + ++L L D A ++W D K
Sbjct: 440 --EPSLIFTNRRD---IRKIGLERKEYIQLV--EQLRNTVALDADIAAQKLFWADLSQKA 492
Query: 1467 IEVARLDGS-SRKV-LITGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIV 1524
I A +D R V +I + P A+A+ +YW+D I + LDG++R+ +
Sbjct: 493 IFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD-AASKTISVATLDGTKRKFLF 551
Query: 1525 QVDLGFPNGLTIDYKERRLYWTD-ALKDRIDTSDLNGQHRVQLV-PDAKNPFGMT--QFK 1580
DL P + +D +YW+D +I+ + +NG R LV D + P G+T K
Sbjct: 552 NSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIK 611
Query: 1581 DYIYWTDWYKKSIIRADKRTGKNITLIRTNLE 1612
+YW D K ++ + G++ ++ +LE
Sbjct: 612 SRLYWLD-SKLHMLSSVDLNGQDRRIVLKSLE 642
Score = 41.5 bits (93), Expect = 0.027
Identities = 19/28 (67%), Positives = 19/28 (67%), Gaps = 1/28 (3%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKT 200
CI L W CDGD DC D SDE NC V KT
Sbjct: 45 CITLLWKCDGDEDCVDGSDEKNC-VKKT 71
Score = 35.1 bits (77), Expect = 2.3
Identities = 14/31 (45%), Positives = 19/31 (61%), Gaps = 1/31 (3%)
Query: 162 ENRTICHSTNVCIALEWLCDGDNDCGDFSDE 192
E+ +C++ C+ W CDGD DC D SDE
Sbjct: 74 ESDFVCNNGQ-CVPSRWKCDGDPDCEDGSDE 103
>AL450467-4|CAH72455.1| 845|Homo sapiens very low density
lipoprotein receptor protein.
Length = 845
Score = 381 bits (937), Expect = e-104
Identities = 213/625 (34%), Positives = 330/625 (52%), Gaps = 60/625 (9%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
R+C HE HST CI + W CDG+ND CD S N G+
Sbjct: 111 RTCRIHEISCGAHSTQ-CIPVSWRCDGEND---------CD---------SGEDEENCGN 151
Query: 216 VITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELM--RCAEIDFECKNT 273
+ +P + + ++ + N + S + ++ C +F+C +
Sbjct: 152 ITCSPDEFTCSSGRCI--------SRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTS 203
Query: 274 KCVPKDFQCDGDNDCGDWTDE--DSC---PMVPGSCNAGEFKCNDGKCIPERWRCDNERD 328
C+P + CD D DC D +DE + C P++ C A E +C G+CI ++WRCD + D
Sbjct: 204 SCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPD 263
Query: 329 CADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV--SC-E 385
C DG DE+NC P+ R C D++ C D C+ + C+G+RDC +G DE+NC+ C
Sbjct: 264 CKDGSDEVNC-PS--RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLG 320
Query: 386 EDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE--ERCPLKRKCSAEEKCEKLC 443
++ CR E C++ VC+ +DC DE + C + C +C
Sbjct: 321 PGKFKCRSGE---------CIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHIC 371
Query: 444 ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQTCSNTVGSFRCGCMTGYI 502
G+ C C GF L D+ +C DIDEC Q+P +CSQ C N G ++C C GY
Sbjct: 372 KDLVIGYE-CDCAAGFELI-DRKTCGDIDEC---QNPGICSQICINLKGGYKCECSRGYQ 426
Query: 503 LRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLVFWS 562
+ CK G+ P+L+F+NR IR++ L Y+ +V+ L N VALD + +FW+
Sbjct: 427 MDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWA 486
Query: 563 ENNLRVIRVAQMNTKNMSDV-IRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSK 621
+ + + I A ++ K V + + PA +AVDW++ ++WTD+ ++ + VATLDG+K
Sbjct: 487 DLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTK 546
Query: 622 RAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLT 681
R L +DL +P +IAV P V+W+DWG KIE+A M+G R+ ++ +I WPNG+T
Sbjct: 547 RKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGIT 606
Query: 682 IDYTESKIYWADAKHHVIERAAFDGRDRRKV--TTKGLPHPFALTLFDDAIYWTDWHTKS 739
+D +S++YW D+K H++ +G+DRR V + + L HP ALT+F+D +YW D ++
Sbjct: 607 LDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEA 666
Query: 740 ISTVNKNTGMGIQTVHAGLNVPMDI 764
+ NK TG + T+ LN DI
Sbjct: 667 VYGANKFTGSELATLVNNLNDAQDI 691
Score = 219 bits (535), Expect = 7e-56
Identities = 127/354 (35%), Positives = 192/354 (54%), Gaps = 24/354 (6%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGPINYLIFAHRVDIRVISLDVPY 1079
+N G CS +C+ GG C C G +++ C A G LIF +R DIR I L+
Sbjct: 401 QNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKE 460
Query: 1080 LIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRAT---RLGTHVETVIGNGLHTA 1136
I +V L+N + +D D + ++W D Q+ I A+ ++G HV+ + + ++
Sbjct: 461 YIQLV---EQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNP 515
Query: 1137 DGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDW 1196
I +D + IYWTD +I VA LDG RK L + L P +IA+ G+++WSDW
Sbjct: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
Query: 1197 GTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRR 1256
G AKIE+A M+G +RR +V I+WPNG+ +D I+ RLYW D+K+ + S D +G DRR
Sbjct: 576 GEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRR 635
Query: 1257 TVLSNVPY---PYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQ 1313
VL ++ + P + I +YW D + +A++ A+K S+ + NL DI +
Sbjct: 636 IVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDI-IVY 694
Query: 1314 SERVL---ENACGTD--NGGCSHLCLRSPL------GYTCACPTGMPFEKSTTD 1356
E V +N C D NGGC +LCL +P YTC+CP+G E++ D
Sbjct: 695 HELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRD 748
Score = 201 bits (490), Expect = 2e-50
Identities = 117/342 (34%), Positives = 179/342 (52%), Gaps = 22/342 (6%)
Query: 1327 GGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEE-FLIFATRGSITYISLES 1385
G CS +C+ GY C C G + +T CK+ +E LIF R I I LE
Sbjct: 404 GICSQICINLKGGYKCECSRGYQMDLATG-----VCKAVGKEPSLIFTNRRDIRKIGLER 458
Query: 1386 PEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETP 1445
E + V++++NT+A+D + +F+ DL I S ++ + + + P
Sbjct: 459 KEYIQL---VEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNP 515
Query: 1446 NGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITG-LTEPRALALFPAKGYLYWSDW 1504
+ VDW+ IYWTD K I VA LDG+ RK L L EP ++A+ P G++YWSDW
Sbjct: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
Query: 1505 GEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHR- 1563
GE IE++ ++G R+ +V D+ +PNG+T+D + RLYW D+ + + DLNGQ R
Sbjct: 576 GEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRR 635
Query: 1564 --VQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAV- 1620
++ + +P +T F+D +YW D +++ A+K TG + + NL A +I
Sbjct: 636 IVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYH 695
Query: 1621 SADRQHGWNPCKE--SNGGCSHLCL----FRGH--EYICACP 1654
+ G N C+E NGGC +LCL H +Y C+CP
Sbjct: 696 ELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCP 737
Score = 180 bits (438), Expect = 4e-44
Identities = 110/331 (33%), Positives = 167/331 (50%), Gaps = 46/331 (13%)
Query: 762 MDIHSRSCEET-PEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKS 820
MD+ + C+ E L++ R+D+R LE K+ I VE +++ VALD D +
Sbjct: 427 MDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQL------VEQLRNTVALDADIAA 480
Query: 821 NSIFWTDVEKDTINRAYLN---GSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIE 877
+FW D+ + I A ++ G H I N+ PA +A DW+ IYWTD + I
Sbjct: 481 QKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNPAAIAVDWVYKTIYWTDAASKTIS 538
Query: 878 VSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQ 937
V+ DG+ R L + +P I V+P G +YWSDWG IE+A M+G +R+ L+
Sbjct: 539 VATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTAD 598
Query: 938 MTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGR---TKLIENLPHPFGLDLYGDEVF 994
+ WPNG+ LDL+ +R+YW D + +L+G R K +E L HP L ++ D V+
Sbjct: 599 IQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVY 658
Query: 995 WTDWDTQSIQAANKDTGAKRRTL------------------GCGKN-------NGGCSHL 1029
W D + +++ ANK TG++ TL GKN NGGC +L
Sbjct: 659 WIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYL 718
Query: 1030 CLLKP------GGRSCACPIGIKLNKDGKTC 1054
CL P +C+CP G + ++G+ C
Sbjct: 719 CLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749
Score = 151 bits (365), Expect = 3e-35
Identities = 68/179 (37%), Positives = 100/179 (55%), Gaps = 16/179 (8%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
+C F+C N +C+ ++CDGD DC D +DE +C V +C +F CN+G+C+P RW
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC--VKKTCAESDFVCNNGQCVPSRW 89
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCA--DRRCVLKTWLCDGVRDCTNGEDEMN 379
+CD + DC DG DE + + +R C + E +C +C+ +W CDG DC +GEDE N
Sbjct: 90 KCDGDPDCEDGSDE-SPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEEN 148
Query: 380 C-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE 437
C ++C D++TC + C++R VC+G DC G DE C C A E
Sbjct: 149 CGNITCSPDEFTC---------SSGRCISRNFVCNGQDDCSDGSDELDC-APPTCGAHE 197
Score = 102 bits (244), Expect = 1e-20
Identities = 83/294 (28%), Positives = 135/294 (45%), Gaps = 15/294 (5%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVP 1078
C NNGGCSH+C G C C G +L D KTC D I+ I+L
Sbjct: 360 CLVNNGGCSHICKDLVIGYECDCAAGFEL-IDRKTCGD--IDECQNPGICSQICINLKGG 416
Query: 1079 YLIDVVLPLP-PLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTAD 1137
Y + L + V LI+ RKI + +++ V L
Sbjct: 417 YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERK--EYIQLV--EQLRNTV 472
Query: 1138 GIVIDSTGRKIYWTDGGRNSIEVAELDGR-NRKVLVWTGLDSPRAIALHYEYGYMFWSDW 1196
+ D +K++W D + +I A +D + R V + + +P AIA+ + Y ++W+D
Sbjct: 473 ALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD- 531
Query: 1197 GTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFDGHDR 1255
S I A +DG R+ + ++ ++ P +A+D + G +YW+D + IE + +G DR
Sbjct: 532 AASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDR 591
Query: 1256 R-TVLSNVPYPYGIV--IVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGL 1306
R V +++ +P GI ++ +YW D K L D N D ++ K+LE L
Sbjct: 592 RPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVD-LNGQDRRIVLKSLEFL 644
Score = 74.5 bits (175), Expect = 3e-12
Identities = 83/332 (25%), Positives = 134/332 (40%), Gaps = 23/332 (6%)
Query: 1290 KTNASDPIVIRKNLEGLMDIRAIQSERVLE---NACGTDNGGCSHLCLRSPLGYTCACPT 1346
K + + I I K D R E + E N C +NGGCSH+C +GY C C
Sbjct: 325 KCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAA 384
Query: 1347 GMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDY 1406
G T +C++ I Q D+ V +
Sbjct: 385 GFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGK----- 439
Query: 1407 HWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKV 1466
+ +IF D IR I + + + ++L L D A ++W D K
Sbjct: 440 --EPSLIFTNRRD---IRKIGLERKEYIQLV--EQLRNTVALDADIAAQKLFWADLSQKA 492
Query: 1467 IEVARLDGS-SRKV-LITGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIV 1524
I A +D R V +I + P A+A+ +YW+D I + LDG++R+ +
Sbjct: 493 IFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD-AASKTISVATLDGTKRKFLF 551
Query: 1525 QVDLGFPNGLTIDYKERRLYWTD-ALKDRIDTSDLNGQHRVQLV-PDAKNPFGMT--QFK 1580
DL P + +D +YW+D +I+ + +NG R LV D + P G+T K
Sbjct: 552 NSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIK 611
Query: 1581 DYIYWTDWYKKSIIRADKRTGKNITLIRTNLE 1612
+YW D K ++ + G++ ++ +LE
Sbjct: 612 SRLYWLD-SKLHMLSSVDLNGQDRRIVLKSLE 642
Score = 41.5 bits (93), Expect = 0.027
Identities = 19/28 (67%), Positives = 19/28 (67%), Gaps = 1/28 (3%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKT 200
CI L W CDGD DC D SDE NC V KT
Sbjct: 45 CITLLWKCDGDEDCVDGSDEKNC-VKKT 71
Score = 35.1 bits (77), Expect = 2.3
Identities = 14/31 (45%), Positives = 19/31 (61%), Gaps = 1/31 (3%)
Query: 162 ENRTICHSTNVCIALEWLCDGDNDCGDFSDE 192
E+ +C++ C+ W CDGD DC D SDE
Sbjct: 74 ESDFVCNNGQ-CVPSRWKCDGDPDCEDGSDE 103
>AL450467-3|CAH72454.1| 873|Homo sapiens very low density
lipoprotein receptor protein.
Length = 873
Score = 381 bits (937), Expect = e-104
Identities = 213/625 (34%), Positives = 330/625 (52%), Gaps = 60/625 (9%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
R+C HE HST CI + W CDG+ND CD S N G+
Sbjct: 111 RTCRIHEISCGAHSTQ-CIPVSWRCDGEND---------CD---------SGEDEENCGN 151
Query: 216 VITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELM--RCAEIDFECKNT 273
+ +P + + ++ + N + S + ++ C +F+C +
Sbjct: 152 ITCSPDEFTCSSGRCI--------SRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTS 203
Query: 274 KCVPKDFQCDGDNDCGDWTDE--DSC---PMVPGSCNAGEFKCNDGKCIPERWRCDNERD 328
C+P + CD D DC D +DE + C P++ C A E +C G+CI ++WRCD + D
Sbjct: 204 SCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPD 263
Query: 329 CADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV--SC-E 385
C DG DE+NC P+ R C D++ C D C+ + C+G+RDC +G DE+NC+ C
Sbjct: 264 CKDGSDEVNC-PS--RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLG 320
Query: 386 EDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE--ERCPLKRKCSAEEKCEKLC 443
++ CR E C++ VC+ +DC DE + C + C +C
Sbjct: 321 PGKFKCRSGE---------CIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHIC 371
Query: 444 ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQTCSNTVGSFRCGCMTGYI 502
G+ C C GF L D+ +C DIDEC Q+P +CSQ C N G ++C C GY
Sbjct: 372 KDLVIGYE-CDCAAGFELI-DRKTCGDIDEC---QNPGICSQICINLKGGYKCECSRGYQ 426
Query: 503 LRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLVFWS 562
+ CK G+ P+L+F+NR IR++ L Y+ +V+ L N VALD + +FW+
Sbjct: 427 MDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWA 486
Query: 563 ENNLRVIRVAQMNTKNMSDV-IRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSK 621
+ + + I A ++ K V + + PA +AVDW++ ++WTD+ ++ + VATLDG+K
Sbjct: 487 DLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTK 546
Query: 622 RAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLT 681
R L +DL +P +IAV P V+W+DWG KIE+A M+G R+ ++ +I WPNG+T
Sbjct: 547 RKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGIT 606
Query: 682 IDYTESKIYWADAKHHVIERAAFDGRDRRKV--TTKGLPHPFALTLFDDAIYWTDWHTKS 739
+D +S++YW D+K H++ +G+DRR V + + L HP ALT+F+D +YW D ++
Sbjct: 607 LDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEA 666
Query: 740 ISTVNKNTGMGIQTVHAGLNVPMDI 764
+ NK TG + T+ LN DI
Sbjct: 667 VYGANKFTGSELATLVNNLNDAQDI 691
Score = 219 bits (535), Expect = 7e-56
Identities = 127/354 (35%), Positives = 192/354 (54%), Gaps = 24/354 (6%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGPINYLIFAHRVDIRVISLDVPY 1079
+N G CS +C+ GG C C G +++ C A G LIF +R DIR I L+
Sbjct: 401 QNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKE 460
Query: 1080 LIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRAT---RLGTHVETVIGNGLHTA 1136
I +V L+N + +D D + ++W D Q+ I A+ ++G HV+ + + ++
Sbjct: 461 YIQLV---EQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNP 515
Query: 1137 DGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDW 1196
I +D + IYWTD +I VA LDG RK L + L P +IA+ G+++WSDW
Sbjct: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
Query: 1197 GTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRR 1256
G AKIE+A M+G +RR +V I+WPNG+ +D I+ RLYW D+K+ + S D +G DRR
Sbjct: 576 GEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRR 635
Query: 1257 TVLSNVPY---PYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQ 1313
VL ++ + P + I +YW D + +A++ A+K S+ + NL DI +
Sbjct: 636 IVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDI-IVY 694
Query: 1314 SERVL---ENACGTD--NGGCSHLCLRSPL------GYTCACPTGMPFEKSTTD 1356
E V +N C D NGGC +LCL +P YTC+CP+G E++ D
Sbjct: 695 HELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRD 748
Score = 202 bits (492), Expect = 1e-50
Identities = 123/379 (32%), Positives = 193/379 (50%), Gaps = 27/379 (7%)
Query: 1327 GGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEE-FLIFATRGSITYISLES 1385
G CS +C+ GY C C G + +T CK+ +E LIF R I I LE
Sbjct: 404 GICSQICINLKGGYKCECSRGYQMDLATG-----VCKAVGKEPSLIFTNRRDIRKIGLER 458
Query: 1386 PEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETP 1445
E + V++++NT+A+D + +F+ DL I S ++ + + + P
Sbjct: 459 KEYIQL---VEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNP 515
Query: 1446 NGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITG-LTEPRALALFPAKGYLYWSDW 1504
+ VDW+ IYWTD K I VA LDG+ RK L L EP ++A+ P G++YWSDW
Sbjct: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
Query: 1505 GEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHR- 1563
GE IE++ ++G R+ +V D+ +PNG+T+D + RLYW D+ + + DLNGQ R
Sbjct: 576 GEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRR 635
Query: 1564 --VQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAV- 1620
++ + +P +T F+D +YW D +++ A+K TG + + NL A +I
Sbjct: 636 IVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYH 695
Query: 1621 SADRQHGWNPCKE--SNGGCSHLCL----FRGH--EYICACPD----DPDHVECSTVKML 1668
+ G N C+E NGGC +LCL H +Y C+CP + + +C +
Sbjct: 696 ELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATT 755
Query: 1669 RNYRDT-ELKDEEFSNSTG 1686
Y +T + E S ++G
Sbjct: 756 VTYSETKDTNTTEISATSG 774
Score = 180 bits (438), Expect = 4e-44
Identities = 110/331 (33%), Positives = 167/331 (50%), Gaps = 46/331 (13%)
Query: 762 MDIHSRSCEET-PEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKS 820
MD+ + C+ E L++ R+D+R LE K+ I VE +++ VALD D +
Sbjct: 427 MDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQL------VEQLRNTVALDADIAA 480
Query: 821 NSIFWTDVEKDTINRAYLN---GSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIE 877
+FW D+ + I A ++ G H I N+ PA +A DW+ IYWTD + I
Sbjct: 481 QKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNPAAIAVDWVYKTIYWTDAASKTIS 538
Query: 878 VSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQ 937
V+ DG+ R L + +P I V+P G +YWSDWG IE+A M+G +R+ L+
Sbjct: 539 VATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTAD 598
Query: 938 MTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGR---TKLIENLPHPFGLDLYGDEVF 994
+ WPNG+ LDL+ +R+YW D + +L+G R K +E L HP L ++ D V+
Sbjct: 599 IQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVY 658
Query: 995 WTDWDTQSIQAANKDTGAKRRTL------------------GCGKN-------NGGCSHL 1029
W D + +++ ANK TG++ TL GKN NGGC +L
Sbjct: 659 WIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYL 718
Query: 1030 CLLKP------GGRSCACPIGIKLNKDGKTC 1054
CL P +C+CP G + ++G+ C
Sbjct: 719 CLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749
Score = 151 bits (365), Expect = 3e-35
Identities = 68/179 (37%), Positives = 100/179 (55%), Gaps = 16/179 (8%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
+C F+C N +C+ ++CDGD DC D +DE +C V +C +F CN+G+C+P RW
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC--VKKTCAESDFVCNNGQCVPSRW 89
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCA--DRRCVLKTWLCDGVRDCTNGEDEMN 379
+CD + DC DG DE + + +R C + E +C +C+ +W CDG DC +GEDE N
Sbjct: 90 KCDGDPDCEDGSDE-SPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEEN 148
Query: 380 C-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE 437
C ++C D++TC + C++R VC+G DC G DE C C A E
Sbjct: 149 CGNITCSPDEFTC---------SSGRCISRNFVCNGQDDCSDGSDELDC-APPTCGAHE 197
Score = 102 bits (244), Expect = 1e-20
Identities = 83/294 (28%), Positives = 135/294 (45%), Gaps = 15/294 (5%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVP 1078
C NNGGCSH+C G C C G +L D KTC D I+ I+L
Sbjct: 360 CLVNNGGCSHICKDLVIGYECDCAAGFEL-IDRKTCGD--IDECQNPGICSQICINLKGG 416
Query: 1079 YLIDVVLPLP-PLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTAD 1137
Y + L + V LI+ RKI + +++ V L
Sbjct: 417 YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERK--EYIQLV--EQLRNTV 472
Query: 1138 GIVIDSTGRKIYWTDGGRNSIEVAELDGR-NRKVLVWTGLDSPRAIALHYEYGYMFWSDW 1196
+ D +K++W D + +I A +D + R V + + +P AIA+ + Y ++W+D
Sbjct: 473 ALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD- 531
Query: 1197 GTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFDGHDR 1255
S I A +DG R+ + ++ ++ P +A+D + G +YW+D + IE + +G DR
Sbjct: 532 AASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDR 591
Query: 1256 R-TVLSNVPYPYGIV--IVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGL 1306
R V +++ +P GI ++ +YW D K L D N D ++ K+LE L
Sbjct: 592 RPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVD-LNGQDRRIVLKSLEFL 644
Score = 74.5 bits (175), Expect = 3e-12
Identities = 83/332 (25%), Positives = 134/332 (40%), Gaps = 23/332 (6%)
Query: 1290 KTNASDPIVIRKNLEGLMDIRAIQSERVLE---NACGTDNGGCSHLCLRSPLGYTCACPT 1346
K + + I I K D R E + E N C +NGGCSH+C +GY C C
Sbjct: 325 KCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAA 384
Query: 1347 GMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDY 1406
G T +C++ I Q D+ V +
Sbjct: 385 GFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGK----- 439
Query: 1407 HWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKV 1466
+ +IF D IR I + + + ++L L D A ++W D K
Sbjct: 440 --EPSLIFTNRRD---IRKIGLERKEYIQLV--EQLRNTVALDADIAAQKLFWADLSQKA 492
Query: 1467 IEVARLDGS-SRKV-LITGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIV 1524
I A +D R V +I + P A+A+ +YW+D I + LDG++R+ +
Sbjct: 493 IFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD-AASKTISVATLDGTKRKFLF 551
Query: 1525 QVDLGFPNGLTIDYKERRLYWTD-ALKDRIDTSDLNGQHRVQLV-PDAKNPFGMT--QFK 1580
DL P + +D +YW+D +I+ + +NG R LV D + P G+T K
Sbjct: 552 NSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIK 611
Query: 1581 DYIYWTDWYKKSIIRADKRTGKNITLIRTNLE 1612
+YW D K ++ + G++ ++ +LE
Sbjct: 612 SRLYWLD-SKLHMLSSVDLNGQDRRIVLKSLE 642
Score = 41.5 bits (93), Expect = 0.027
Identities = 19/28 (67%), Positives = 19/28 (67%), Gaps = 1/28 (3%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKT 200
CI L W CDGD DC D SDE NC V KT
Sbjct: 45 CITLLWKCDGDEDCVDGSDEKNC-VKKT 71
Score = 35.1 bits (77), Expect = 2.3
Identities = 14/31 (45%), Positives = 19/31 (61%), Gaps = 1/31 (3%)
Query: 162 ENRTICHSTNVCIALEWLCDGDNDCGDFSDE 192
E+ +C++ C+ W CDGD DC D SDE
Sbjct: 74 ESDFVCNNGQ-CVPSRWKCDGDPDCEDGSDE 103
>L20470-1|AAA53684.1| 873|Homo sapiens very low density lipoprotein
receptor protein.
Length = 873
Score = 376 bits (926), Expect = e-103
Identities = 212/625 (33%), Positives = 328/625 (52%), Gaps = 60/625 (9%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
R+C HE HST CI + W CDG+ND CD S N G+
Sbjct: 111 RTCRIHEISCGAHSTQ-CIPVSWRCDGEND---------CD---------SGEDEENCGN 151
Query: 216 VITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELM--RCAEIDFECKNT 273
+ +P + + ++ + N + S + ++ C +F+C +
Sbjct: 152 ITCSPDEFTCSSGRCI--------SRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTS 203
Query: 274 KCVPKDFQCDGDNDCGDWTDE--DSC---PMVPGSCNAGEFKCNDGKCIPERWRCDNERD 328
C+P + CD D DC D +DE + C P++ C A E +C G+CI ++WRCD + D
Sbjct: 204 SCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPD 263
Query: 329 CADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV--SC-E 385
C DG DE+NC P+ R C D++ C D C+ + C+G+RDC +G DE+NC+ C
Sbjct: 264 CKDGSDEVNC-PS--RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLG 320
Query: 386 EDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE--ERCPLKRKCSAEEKCEKLC 443
++ CR E C++ VC+ +DC DE + C + C +C
Sbjct: 321 PGKFKCRSGE---------CIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHIC 371
Query: 444 ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQTCSNTVGSFRCGCMTGYI 502
G+ C C GF L D+ +C DIDEC Q+P +CSQ C N G ++C C Y
Sbjct: 372 KDLVIGYE-CDCAAGFELI-DRKTCGDIDEC---QNPGICSQICINLKGGYKCECSRAYQ 426
Query: 503 LRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLVFWS 562
+ CK G+ P+L+F+NR IR++ L Y+ +V+ L N VALD + +FW+
Sbjct: 427 MDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWA 486
Query: 563 ENNLRVIRVAQMNTKNMSDV-IRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSK 621
+ + + I A ++ K V + + PA +AVDW++ ++WTD+ ++ + VATLDG+K
Sbjct: 487 DLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTK 546
Query: 622 RAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLT 681
R L +DL +P +IAV P V+W+DWG KIE+A M+G R+ ++ +I WPNG+T
Sbjct: 547 RKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGIT 606
Query: 682 IDYTESKIYWADAKHHVIERAAFDGRDRRKV--TTKGLPHPFALTLFDDAIYWTDWHTKS 739
+D +S++YW D+K H++ +G+DRR V + + L HP ALT+F+D +YW D ++
Sbjct: 607 LDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEA 666
Query: 740 ISTVNKNTGMGIQTVHAGLNVPMDI 764
+ NK TG T+ LN DI
Sbjct: 667 VYGANKFTGSEHATLVNNLNDAQDI 691
Score = 217 bits (530), Expect = 3e-55
Identities = 126/354 (35%), Positives = 191/354 (53%), Gaps = 24/354 (6%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGPINYLIFAHRVDIRVISLDVPY 1079
+N G CS +C+ GG C C +++ C A G LIF +R DIR I L+
Sbjct: 401 QNPGICSQICINLKGGYKCECSRAYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKE 460
Query: 1080 LIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRAT---RLGTHVETVIGNGLHTA 1136
I +V L+N + +D D + ++W D Q+ I A+ ++G HV+ + + ++
Sbjct: 461 YIQLV---EQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNP 515
Query: 1137 DGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDW 1196
I +D + IYWTD +I VA LDG RK L + L P +IA+ G+++WSDW
Sbjct: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
Query: 1197 GTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRR 1256
G AKIE+A M+G +RR +V I+WPNG+ +D I+ RLYW D+K+ + S D +G DRR
Sbjct: 576 GEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRR 635
Query: 1257 TVLSNVPY---PYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQ 1313
VL ++ + P + I +YW D + +A++ A+K S+ + NL DI +
Sbjct: 636 IVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSEHATLVNNLNDAQDI-IVY 694
Query: 1314 SERVL---ENACGTD--NGGCSHLCLRSPL------GYTCACPTGMPFEKSTTD 1356
E V +N C D NGGC +LCL +P YTC+CP+G E++ D
Sbjct: 695 HELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRD 748
Score = 197 bits (481), Expect = 3e-49
Identities = 122/379 (32%), Positives = 191/379 (50%), Gaps = 27/379 (7%)
Query: 1327 GGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEE-FLIFATRGSITYISLES 1385
G CS +C+ GY C C + +T CK+ +E LIF R I I LE
Sbjct: 404 GICSQICINLKGGYKCECSRAYQMDLATG-----VCKAVGKEPSLIFTNRRDIRKIGLER 458
Query: 1386 PEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETP 1445
E + V++++NT+A+D + +F+ DL I S ++ + + + P
Sbjct: 459 KEYIQL---VEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNP 515
Query: 1446 NGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITG-LTEPRALALFPAKGYLYWSDW 1504
+ VDW+ IYWTD K I VA LDG+ RK L L EP ++A+ P G++YWSDW
Sbjct: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
Query: 1505 GEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHR- 1563
GE IE++ ++G R+ +V D+ +PNG+T+D + RLYW D+ + + DLNGQ R
Sbjct: 576 GEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRR 635
Query: 1564 --VQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAV- 1620
++ + +P +T F+D +YW D +++ A+K TG + NL A +I
Sbjct: 636 IVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSEHATLVNNLNDAQDIIVYH 695
Query: 1621 SADRQHGWNPCKE--SNGGCSHLCL----FRGH--EYICACPD----DPDHVECSTVKML 1668
+ G N C+E NGGC +LCL H +Y C+CP + + +C +
Sbjct: 696 ELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATT 755
Query: 1669 RNYRDT-ELKDEEFSNSTG 1686
Y +T + E S ++G
Sbjct: 756 VTYSETKDTNTTEISATSG 774
Score = 181 bits (440), Expect = 2e-44
Identities = 110/331 (33%), Positives = 167/331 (50%), Gaps = 46/331 (13%)
Query: 762 MDIHSRSCEET-PEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKS 820
MD+ + C+ E L++ R+D+R LE K+ I VE +++ VALD D +
Sbjct: 427 MDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQL------VEQLRNTVALDADIAA 480
Query: 821 NSIFWTDVEKDTINRAYLN---GSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIE 877
+FW D+ + I A ++ G H I N+ PA +A DW+ IYWTD + I
Sbjct: 481 QKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNPAAIAVDWVYKTIYWTDAASKTIS 538
Query: 878 VSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQ 937
V+ DG+ R L + +P I V+P G +YWSDWG IE+A M+G +R+ L+
Sbjct: 539 VATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTAD 598
Query: 938 MTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGR---TKLIENLPHPFGLDLYGDEVF 994
+ WPNG+ LDL+ +R+YW D + +L+G R K +E L HP L ++ D V+
Sbjct: 599 IQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVY 658
Query: 995 WTDWDTQSIQAANKDTGAKRRTL------------------GCGKN-------NGGCSHL 1029
W D + +++ ANK TG++ TL GKN NGGC +L
Sbjct: 659 WIDGENEAVYGANKFTGSEHATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYL 718
Query: 1030 CLLKP------GGRSCACPIGIKLNKDGKTC 1054
CL P +C+CP G + ++G+ C
Sbjct: 719 CLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749
Score = 151 bits (365), Expect = 3e-35
Identities = 68/179 (37%), Positives = 100/179 (55%), Gaps = 16/179 (8%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
+C F+C N +C+ ++CDGD DC D +DE +C V +C +F CN+G+C+P RW
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC--VKKTCAESDFVCNNGQCVPSRW 89
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCA--DRRCVLKTWLCDGVRDCTNGEDEMN 379
+CD + DC DG DE + + +R C + E +C +C+ +W CDG DC +GEDE N
Sbjct: 90 KCDGDPDCEDGSDE-SPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEEN 148
Query: 380 C-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE 437
C ++C D++TC + C++R VC+G DC G DE C C A E
Sbjct: 149 CGNITCSPDEFTC---------SSGRCISRNFVCNGQDDCSDGSDELDC-APPTCGAHE 197
Score = 102 bits (245), Expect = 1e-20
Identities = 83/294 (28%), Positives = 135/294 (45%), Gaps = 15/294 (5%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVP 1078
C NNGGCSH+C G C C G +L D KTC D I+ I+L
Sbjct: 360 CLVNNGGCSHICKDLVIGYECDCAAGFEL-IDRKTCGD--IDECQNPGICSQICINLKGG 416
Query: 1079 YLIDVVLPLP-PLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTAD 1137
Y + L + V LI+ RKI + +++ V L
Sbjct: 417 YKCECSRAYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERK--EYIQLV--EQLRNTV 472
Query: 1138 GIVIDSTGRKIYWTDGGRNSIEVAELDGR-NRKVLVWTGLDSPRAIALHYEYGYMFWSDW 1196
+ D +K++W D + +I A +D + R V + + +P AIA+ + Y ++W+D
Sbjct: 473 ALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD- 531
Query: 1197 GTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFDGHDR 1255
S I A +DG R+ + ++ ++ P +A+D + G +YW+D + IE + +G DR
Sbjct: 532 AASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDR 591
Query: 1256 R-TVLSNVPYPYGIV--IVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGL 1306
R V +++ +P GI ++ +YW D K L D N D ++ K+LE L
Sbjct: 592 RPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVD-LNGQDRRIVLKSLEFL 644
Score = 74.9 bits (176), Expect = 2e-12
Identities = 83/332 (25%), Positives = 134/332 (40%), Gaps = 23/332 (6%)
Query: 1290 KTNASDPIVIRKNLEGLMDIRAIQSERVLE---NACGTDNGGCSHLCLRSPLGYTCACPT 1346
K + + I I K D R E + E N C +NGGCSH+C +GY C C
Sbjct: 325 KCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAA 384
Query: 1347 GMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDY 1406
G T +C++ I Q D+ V +
Sbjct: 385 GFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRAYQMDLATGVCKAVGK----- 439
Query: 1407 HWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKV 1466
+ +IF D IR I + + + ++L L D A ++W D K
Sbjct: 440 --EPSLIFTNRRD---IRKIGLERKEYIQLV--EQLRNTVALDADIAAQKLFWADLSQKA 492
Query: 1467 IEVARLDGS-SRKV-LITGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIV 1524
I A +D R V +I + P A+A+ +YW+D I + LDG++R+ +
Sbjct: 493 IFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD-AASKTISVATLDGTKRKFLF 551
Query: 1525 QVDLGFPNGLTIDYKERRLYWTD-ALKDRIDTSDLNGQHRVQLV-PDAKNPFGMT--QFK 1580
DL P + +D +YW+D +I+ + +NG R LV D + P G+T K
Sbjct: 552 NSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIK 611
Query: 1581 DYIYWTDWYKKSIIRADKRTGKNITLIRTNLE 1612
+YW D K ++ + G++ ++ +LE
Sbjct: 612 SRLYWLD-SKLHMLSSVDLNGQDRRIVLKSLE 642
Score = 41.5 bits (93), Expect = 0.027
Identities = 19/28 (67%), Positives = 19/28 (67%), Gaps = 1/28 (3%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKT 200
CI L W CDGD DC D SDE NC V KT
Sbjct: 45 CITLLWKCDGDEDCVDGSDEKNC-VKKT 71
Score = 35.1 bits (77), Expect = 2.3
Identities = 14/31 (45%), Positives = 19/31 (61%), Gaps = 1/31 (3%)
Query: 162 ENRTICHSTNVCIALEWLCDGDNDCGDFSDE 192
E+ +C++ C+ W CDGD DC D SDE
Sbjct: 74 ESDFVCNNGQ-CVPSRWKCDGDPDCEDGSDE 103
>AL450467-2|CAH72453.1| 752|Homo sapiens very low density
lipoprotein receptor protein.
Length = 752
Score = 375 bits (922), Expect = e-103
Identities = 190/516 (36%), Positives = 292/516 (56%), Gaps = 31/516 (6%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDE--DSC---PMVPGSCNAGEFKCNDGKCI 317
C +F+C + C+P + CD D DC D +DE + C P++ C A E +C G+CI
Sbjct: 72 CGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECI 131
Query: 318 PERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDE 377
++WRCD + DC DG DE+NC P+ R C D++ C D C+ + C+G+RDC +G DE
Sbjct: 132 HKKWRCDGDPDCKDGSDEVNC-PS--RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDE 188
Query: 378 MNCEV--SC-EEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE--ERCPLKRK 432
+NC+ C ++ CR E C++ VC+ +DC DE + C +
Sbjct: 189 VNCKNVNQCLGPGKFKCRSGE---------CIDISKVCNQEQDCRDWSDEPLKECHINEC 239
Query: 433 CSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQTCSNTVG 491
C +C G+ C C GF L D+ +C DIDEC Q+P +CSQ C N G
Sbjct: 240 LVNNGGCSHICKDLVIGYE-CDCAAGFELI-DRKTCGDIDEC---QNPGICSQICINLKG 294
Query: 492 SFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALD 551
++C C GY + CK G+ P+L+F+NR IR++ L Y+ +V+ L N VALD
Sbjct: 295 GYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALD 354
Query: 552 YHYEKKLVFWSENNLRVIRVAQMNTKNMSDV-IRWGLETPAGVAVDWIHDLLFWTDSGTR 610
+ +FW++ + + I A ++ K V + + PA +AVDW++ ++WTD+ ++
Sbjct: 355 ADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASK 414
Query: 611 RVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVI 670
+ VATLDG+KR L +DL +P +IAV P V+W+DWG KIE+A M+G R+ ++
Sbjct: 415 TISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLV 474
Query: 671 YDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKV--TTKGLPHPFALTLFDD 728
+I WPNG+T+D +S++YW D+K H++ +G+DRR V + + L HP ALT+F+D
Sbjct: 475 TADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFED 534
Query: 729 AIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDI 764
+YW D +++ NK TG + T+ LN DI
Sbjct: 535 RVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDI 570
Score = 219 bits (535), Expect = 7e-56
Identities = 127/354 (35%), Positives = 192/354 (54%), Gaps = 24/354 (6%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGPINYLIFAHRVDIRVISLDVPY 1079
+N G CS +C+ GG C C G +++ C A G LIF +R DIR I L+
Sbjct: 280 QNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKE 339
Query: 1080 LIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRAT---RLGTHVETVIGNGLHTA 1136
I +V L+N + +D D + ++W D Q+ I A+ ++G HV+ + + ++
Sbjct: 340 YIQLV---EQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNP 394
Query: 1137 DGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDW 1196
I +D + IYWTD +I VA LDG RK L + L P +IA+ G+++WSDW
Sbjct: 395 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 454
Query: 1197 GTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRR 1256
G AKIE+A M+G +RR +V I+WPNG+ +D I+ RLYW D+K+ + S D +G DRR
Sbjct: 455 GEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRR 514
Query: 1257 TVLSNVPY---PYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQ 1313
VL ++ + P + I +YW D + +A++ A+K S+ + NL DI +
Sbjct: 515 IVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDI-IVY 573
Query: 1314 SERVL---ENACGTD--NGGCSHLCLRSPL------GYTCACPTGMPFEKSTTD 1356
E V +N C D NGGC +LCL +P YTC+CP+G E++ D
Sbjct: 574 HELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRD 627
Score = 208 bits (508), Expect = 1e-52
Identities = 143/500 (28%), Positives = 221/500 (44%), Gaps = 37/500 (7%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
+C F+C N +C+ ++CDGD DC D +DE C P +C A EF+C+ CIP W
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDELDC--APPTCGAHEFQCSTSSCIPISW 89
Query: 322 RCDNERDCADGGDEL--NC--KPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDE 377
CD++ DC+D DE C +P C E C C+ K W CDG DC +G DE
Sbjct: 90 VCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDE 149
Query: 378 MNC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAE 436
+NC +C DQ+ C +C++ C+G++DC G DE C +C
Sbjct: 150 VNCPSRTCRPDQFECED---------GSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGP 200
Query: 437 EKCEKLCITTYDGHAACACPMGFLLAEDK--YSCRDIDECMYEQDPVCSQTCSNTVGSFR 494
K + D C D+ C I+EC+ CS C + V +
Sbjct: 201 GKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECH-INECLVNNGG-CSHICKDLVIGYE 258
Query: 495 CGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKG----LHNAVAL 550
C C G+ L D ++C E ++I I L G +G L V
Sbjct: 259 CDCAAGFEL-IDRKTCGDIDECQNPGICSQICIN---LKGGYKCECSRGYQMDLATGVCK 314
Query: 551 DYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTR 610
E L+F + ++R I + + + + +R + A +A LFW D +
Sbjct: 315 AVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA----QKLFWADLSQK 370
Query: 611 RVEVATLDGS-KRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTV 669
+ A++D R V + +++ P AIAV ++WTD + I A +DG KRK +
Sbjct: 371 AIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD-AASKTISVATLDGTKRKFL 429
Query: 670 IYDEIFWPNGLTIDYTESKIYWAD-AKHHVIERAAFDGRDRRKVTTKGL--PHPFALTLF 726
++ P + +D +YW+D + IE+A +G DRR + T + P+ L L
Sbjct: 430 FNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLI 489
Query: 727 DDAIYWTDWHTKSISTVNKN 746
+YW D +S+V+ N
Sbjct: 490 KSRLYWLDSKLHMLSSVDLN 509
Score = 202 bits (492), Expect = 1e-50
Identities = 123/379 (32%), Positives = 193/379 (50%), Gaps = 27/379 (7%)
Query: 1327 GGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEE-FLIFATRGSITYISLES 1385
G CS +C+ GY C C G + +T CK+ +E LIF R I I LE
Sbjct: 283 GICSQICINLKGGYKCECSRGYQMDLATG-----VCKAVGKEPSLIFTNRRDIRKIGLER 337
Query: 1386 PEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETP 1445
E + V++++NT+A+D + +F+ DL I S ++ + + + P
Sbjct: 338 KEYIQL---VEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNP 394
Query: 1446 NGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITG-LTEPRALALFPAKGYLYWSDW 1504
+ VDW+ IYWTD K I VA LDG+ RK L L EP ++A+ P G++YWSDW
Sbjct: 395 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 454
Query: 1505 GEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHR- 1563
GE IE++ ++G R+ +V D+ +PNG+T+D + RLYW D+ + + DLNGQ R
Sbjct: 455 GEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRR 514
Query: 1564 --VQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAV- 1620
++ + +P +T F+D +YW D +++ A+K TG + + NL A +I
Sbjct: 515 IVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYH 574
Query: 1621 SADRQHGWNPCKE--SNGGCSHLCL----FRGH--EYICACPD----DPDHVECSTVKML 1668
+ G N C+E NGGC +LCL H +Y C+CP + + +C +
Sbjct: 575 ELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATT 634
Query: 1669 RNYRDT-ELKDEEFSNSTG 1686
Y +T + E S ++G
Sbjct: 635 VTYSETKDTNTTEISATSG 653
Score = 180 bits (438), Expect = 4e-44
Identities = 110/331 (33%), Positives = 167/331 (50%), Gaps = 46/331 (13%)
Query: 762 MDIHSRSCEET-PEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKS 820
MD+ + C+ E L++ R+D+R LE K+ I VE +++ VALD D +
Sbjct: 306 MDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQL------VEQLRNTVALDADIAA 359
Query: 821 NSIFWTDVEKDTINRAYLN---GSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIE 877
+FW D+ + I A ++ G H I N+ PA +A DW+ IYWTD + I
Sbjct: 360 QKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNPAAIAVDWVYKTIYWTDAASKTIS 417
Query: 878 VSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQ 937
V+ DG+ R L + +P I V+P G +YWSDWG IE+A M+G +R+ L+
Sbjct: 418 VATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTAD 477
Query: 938 MTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGR---TKLIENLPHPFGLDLYGDEVF 994
+ WPNG+ LDL+ +R+YW D + +L+G R K +E L HP L ++ D V+
Sbjct: 478 IQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVY 537
Query: 995 WTDWDTQSIQAANKDTGAKRRTL------------------GCGKN-------NGGCSHL 1029
W D + +++ ANK TG++ TL GKN NGGC +L
Sbjct: 538 WIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYL 597
Query: 1030 CLLKP------GGRSCACPIGIKLNKDGKTC 1054
CL P +C+CP G + ++G+ C
Sbjct: 598 CLPAPQINDHSPKYTCSCPSGYNVEENGRDC 628
Score = 122 bits (295), Expect = 9e-27
Identities = 84/291 (28%), Positives = 135/291 (46%), Gaps = 35/291 (12%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
CI L W CDGD DC D SDE++C P+ A + T+ + I+ V
Sbjct: 45 CITLLWKCDGDEDCVDGSDELDC-------APPTCGA--HEFQCSTSSCIPISW-----V 90
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWT 292
++ C+ ++ ++ QPV +C + +C + +C+ K ++CDGD DC D +
Sbjct: 91 CDDDADCSDQSDESL---EQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGS 147
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNC-SLDEY 351
DE +CP +C +F+C DG CI +C+ RDC DG DE+NCK ++ C ++
Sbjct: 148 DEVNCP--SRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCK--NVNQCLGPGKF 203
Query: 352 TCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHV 411
C C+ + +C+ +DC + DE E C E L++N + + + V
Sbjct: 204 KCRSGECIDISKVCNQEQDCRDWSDEPLKE---------CHINECLVNNGGCSHICKDLV 254
Query: 412 CDGMKDCPRG---DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGF 459
DC G D + C +C C ++CI G+ C C G+
Sbjct: 255 IGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGY-KCECSRGY 304
Score = 102 bits (244), Expect = 1e-20
Identities = 83/294 (28%), Positives = 135/294 (45%), Gaps = 15/294 (5%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVP 1078
C NNGGCSH+C G C C G +L D KTC D I+ I+L
Sbjct: 239 CLVNNGGCSHICKDLVIGYECDCAAGFEL-IDRKTCGD--IDECQNPGICSQICINLKGG 295
Query: 1079 YLIDVVLPLP-PLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTAD 1137
Y + L + V LI+ RKI + +++ V L
Sbjct: 296 YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERK--EYIQLV--EQLRNTV 351
Query: 1138 GIVIDSTGRKIYWTDGGRNSIEVAELDGR-NRKVLVWTGLDSPRAIALHYEYGYMFWSDW 1196
+ D +K++W D + +I A +D + R V + + +P AIA+ + Y ++W+D
Sbjct: 352 ALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD- 410
Query: 1197 GTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFDGHDR 1255
S I A +DG R+ + ++ ++ P +A+D + G +YW+D + IE + +G DR
Sbjct: 411 AASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDR 470
Query: 1256 R-TVLSNVPYPYGIV--IVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGL 1306
R V +++ +P GI ++ +YW D K L D N D ++ K+LE L
Sbjct: 471 RPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVD-LNGQDRRIVLKSLEFL 523
Score = 74.5 bits (175), Expect = 3e-12
Identities = 83/332 (25%), Positives = 134/332 (40%), Gaps = 23/332 (6%)
Query: 1290 KTNASDPIVIRKNLEGLMDIRAIQSERVLE---NACGTDNGGCSHLCLRSPLGYTCACPT 1346
K + + I I K D R E + E N C +NGGCSH+C +GY C C
Sbjct: 204 KCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAA 263
Query: 1347 GMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDY 1406
G T +C++ I Q D+ V +
Sbjct: 264 GFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGK----- 318
Query: 1407 HWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKV 1466
+ +IF D IR I + + + ++L L D A ++W D K
Sbjct: 319 --EPSLIFTNRRD---IRKIGLERKEYIQLV--EQLRNTVALDADIAAQKLFWADLSQKA 371
Query: 1467 IEVARLDGS-SRKV-LITGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIV 1524
I A +D R V +I + P A+A+ +YW+D I + LDG++R+ +
Sbjct: 372 IFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD-AASKTISVATLDGTKRKFLF 430
Query: 1525 QVDLGFPNGLTIDYKERRLYWTD-ALKDRIDTSDLNGQHRVQLV-PDAKNPFGMT--QFK 1580
DL P + +D +YW+D +I+ + +NG R LV D + P G+T K
Sbjct: 431 NSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIK 490
Query: 1581 DYIYWTDWYKKSIIRADKRTGKNITLIRTNLE 1612
+YW D K ++ + G++ ++ +LE
Sbjct: 491 SRLYWLD-SKLHMLSSVDLNGQDRRIVLKSLE 521
Score = 39.9 bits (89), Expect = 0.081
Identities = 18/36 (50%), Positives = 23/36 (63%), Gaps = 3/36 (8%)
Query: 157 SCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDE 192
+C HE + C ST+ CI + W+CD D DC D SDE
Sbjct: 71 TCGAHEFQ--C-STSSCIPISWVCDDDADCSDQSDE 103
>AK092381-1|BAC03874.1| 752|Homo sapiens protein ( Homo sapiens
cDNA FLJ35062 fis, clone OCBBF2019195, highly similar to
VERY LOW-DENSITY LIPOPROTEIN RECEPTOR PRECURSOR. ).
Length = 752
Score = 375 bits (922), Expect = e-103
Identities = 190/516 (36%), Positives = 292/516 (56%), Gaps = 31/516 (6%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDE--DSC---PMVPGSCNAGEFKCNDGKCI 317
C +F+C + C+P + CD D DC D +DE + C P++ C A E +C G+CI
Sbjct: 72 CGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECI 131
Query: 318 PERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDE 377
++WRCD + DC DG DE+NC P+ R C D++ C D C+ + C+G+RDC +G DE
Sbjct: 132 HKKWRCDGDPDCKDGSDEVNC-PS--RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDE 188
Query: 378 MNCEV--SC-EEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE--ERCPLKRK 432
+NC+ C ++ CR E C++ VC+ +DC DE + C +
Sbjct: 189 VNCKNVNQCLGPGKFKCRSGE---------CIDISKVCNQEQDCRDWSDEPLKECHINEC 239
Query: 433 CSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQTCSNTVG 491
C +C G+ C C GF L D+ +C DIDEC Q+P +CSQ C N G
Sbjct: 240 LVNNGGCSHICKDLVIGYE-CDCAAGFELI-DRKTCGDIDEC---QNPGICSQICINLKG 294
Query: 492 SFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALD 551
++C C GY + CK G+ P+L+F+NR IR++ L Y+ +V+ L N VALD
Sbjct: 295 GYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALD 354
Query: 552 YHYEKKLVFWSENNLRVIRVAQMNTKNMSDV-IRWGLETPAGVAVDWIHDLLFWTDSGTR 610
+ +FW++ + + I A ++ K V + + PA +AVDW++ ++WTD+ ++
Sbjct: 355 ADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASK 414
Query: 611 RVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVI 670
+ VATLDG+KR L +DL +P +IAV P V+W+DWG KIE+A M+G R+ ++
Sbjct: 415 TISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLV 474
Query: 671 YDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKV--TTKGLPHPFALTLFDD 728
+I WPNG+T+D +S++YW D+K H++ +G+DRR V + + L HP ALT+F+D
Sbjct: 475 TADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFED 534
Query: 729 AIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDI 764
+YW D +++ NK TG + T+ LN DI
Sbjct: 535 RVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDI 570
Score = 219 bits (535), Expect = 7e-56
Identities = 127/354 (35%), Positives = 192/354 (54%), Gaps = 24/354 (6%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGPINYLIFAHRVDIRVISLDVPY 1079
+N G CS +C+ GG C C G +++ C A G LIF +R DIR I L+
Sbjct: 280 QNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKE 339
Query: 1080 LIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRAT---RLGTHVETVIGNGLHTA 1136
I +V L+N + +D D + ++W D Q+ I A+ ++G HV+ + + ++
Sbjct: 340 YIQLV---EQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNP 394
Query: 1137 DGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDW 1196
I +D + IYWTD +I VA LDG RK L + L P +IA+ G+++WSDW
Sbjct: 395 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 454
Query: 1197 GTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRR 1256
G AKIE+A M+G +RR +V I+WPNG+ +D I+ RLYW D+K+ + S D +G DRR
Sbjct: 455 GEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRR 514
Query: 1257 TVLSNVPY---PYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQ 1313
VL ++ + P + I +YW D + +A++ A+K S+ + NL DI +
Sbjct: 515 IVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDI-IVY 573
Query: 1314 SERVL---ENACGTD--NGGCSHLCLRSPL------GYTCACPTGMPFEKSTTD 1356
E V +N C D NGGC +LCL +P YTC+CP+G E++ D
Sbjct: 574 HELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRD 627
Score = 208 bits (508), Expect = 1e-52
Identities = 143/500 (28%), Positives = 221/500 (44%), Gaps = 37/500 (7%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
+C F+C N +C+ ++CDGD DC D +DE C P +C A EF+C+ CIP W
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDELDC--APPTCGAHEFQCSTSSCIPISW 89
Query: 322 RCDNERDCADGGDEL--NC--KPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDE 377
CD++ DC+D DE C +P C E C C+ K W CDG DC +G DE
Sbjct: 90 VCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDE 149
Query: 378 MNC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAE 436
+NC +C DQ+ C +C++ C+G++DC G DE C +C
Sbjct: 150 VNCPSRTCRPDQFECED---------GSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGP 200
Query: 437 EKCEKLCITTYDGHAACACPMGFLLAEDK--YSCRDIDECMYEQDPVCSQTCSNTVGSFR 494
K + D C D+ C I+EC+ CS C + V +
Sbjct: 201 GKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECH-INECLVNNGG-CSHICKDLVIGYE 258
Query: 495 CGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKG----LHNAVAL 550
C C G+ L D ++C E ++I I L G +G L V
Sbjct: 259 CDCAAGFEL-IDRKTCGDIDECQNPGICSQICIN---LKGGYKCECSRGYQMDLATGVCK 314
Query: 551 DYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTR 610
E L+F + ++R I + + + + +R + A +A LFW D +
Sbjct: 315 AVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA----QKLFWADLSQK 370
Query: 611 RVEVATLDGS-KRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTV 669
+ A++D R V + +++ P AIAV ++WTD + I A +DG KRK +
Sbjct: 371 AIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD-AASKTISVATLDGTKRKFL 429
Query: 670 IYDEIFWPNGLTIDYTESKIYWAD-AKHHVIERAAFDGRDRRKVTTKGL--PHPFALTLF 726
++ P + +D +YW+D + IE+A +G DRR + T + P+ L L
Sbjct: 430 FNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLI 489
Query: 727 DDAIYWTDWHTKSISTVNKN 746
+YW D +S+V+ N
Sbjct: 490 KSRLYWLDSKLHMLSSVDLN 509
Score = 202 bits (492), Expect = 1e-50
Identities = 123/379 (32%), Positives = 193/379 (50%), Gaps = 27/379 (7%)
Query: 1327 GGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEE-FLIFATRGSITYISLES 1385
G CS +C+ GY C C G + +T CK+ +E LIF R I I LE
Sbjct: 283 GICSQICINLKGGYKCECSRGYQMDLATG-----VCKAVGKEPSLIFTNRRDIRKIGLER 337
Query: 1386 PEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETP 1445
E + V++++NT+A+D + +F+ DL I S ++ + + + P
Sbjct: 338 KEYIQL---VEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNP 394
Query: 1446 NGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITG-LTEPRALALFPAKGYLYWSDW 1504
+ VDW+ IYWTD K I VA LDG+ RK L L EP ++A+ P G++YWSDW
Sbjct: 395 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 454
Query: 1505 GEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHR- 1563
GE IE++ ++G R+ +V D+ +PNG+T+D + RLYW D+ + + DLNGQ R
Sbjct: 455 GEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRR 514
Query: 1564 --VQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAV- 1620
++ + +P +T F+D +YW D +++ A+K TG + + NL A +I
Sbjct: 515 IVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYH 574
Query: 1621 SADRQHGWNPCKE--SNGGCSHLCL----FRGH--EYICACPD----DPDHVECSTVKML 1668
+ G N C+E NGGC +LCL H +Y C+CP + + +C +
Sbjct: 575 ELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATT 634
Query: 1669 RNYRDT-ELKDEEFSNSTG 1686
Y +T + E S ++G
Sbjct: 635 VTYSETKDTNTTEISATSG 653
Score = 180 bits (438), Expect = 4e-44
Identities = 110/331 (33%), Positives = 167/331 (50%), Gaps = 46/331 (13%)
Query: 762 MDIHSRSCEET-PEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKS 820
MD+ + C+ E L++ R+D+R LE K+ I VE +++ VALD D +
Sbjct: 306 MDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQL------VEQLRNTVALDADIAA 359
Query: 821 NSIFWTDVEKDTINRAYLN---GSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIE 877
+FW D+ + I A ++ G H I N+ PA +A DW+ IYWTD + I
Sbjct: 360 QKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNPAAIAVDWVYKTIYWTDAASKTIS 417
Query: 878 VSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQ 937
V+ DG+ R L + +P I V+P G +YWSDWG IE+A M+G +R+ L+
Sbjct: 418 VATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTAD 477
Query: 938 MTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGR---TKLIENLPHPFGLDLYGDEVF 994
+ WPNG+ LDL+ +R+YW D + +L+G R K +E L HP L ++ D V+
Sbjct: 478 IQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVY 537
Query: 995 WTDWDTQSIQAANKDTGAKRRTL------------------GCGKN-------NGGCSHL 1029
W D + +++ ANK TG++ TL GKN NGGC +L
Sbjct: 538 WIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYL 597
Query: 1030 CLLKP------GGRSCACPIGIKLNKDGKTC 1054
CL P +C+CP G + ++G+ C
Sbjct: 598 CLPAPQINDHSPKYTCSCPSGYNVEENGRDC 628
Score = 122 bits (295), Expect = 9e-27
Identities = 84/291 (28%), Positives = 135/291 (46%), Gaps = 35/291 (12%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
CI L W CDGD DC D SDE++C P+ A + T+ + I+ V
Sbjct: 45 CITLLWKCDGDEDCVDGSDELDC-------APPTCGA--HEFQCSTSSCIPISW-----V 90
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWT 292
++ C+ ++ ++ QPV +C + +C + +C+ K ++CDGD DC D +
Sbjct: 91 CDDDADCSDQSDESL---EQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGS 147
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNC-SLDEY 351
DE +CP +C +F+C DG CI +C+ RDC DG DE+NCK ++ C ++
Sbjct: 148 DEVNCP--SRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCK--NVNQCLGPGKF 203
Query: 352 TCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHV 411
C C+ + +C+ +DC + DE E C E L++N + + + V
Sbjct: 204 KCRSGECIDISKVCNQEQDCRDWSDEPLKE---------CHINECLVNNGGCSHICKDLV 254
Query: 412 CDGMKDCPRG---DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGF 459
DC G D + C +C C ++CI G+ C C G+
Sbjct: 255 IGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGY-KCECSRGY 304
Score = 102 bits (244), Expect = 1e-20
Identities = 83/294 (28%), Positives = 135/294 (45%), Gaps = 15/294 (5%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVP 1078
C NNGGCSH+C G C C G +L D KTC D I+ I+L
Sbjct: 239 CLVNNGGCSHICKDLVIGYECDCAAGFEL-IDRKTCGD--IDECQNPGICSQICINLKGG 295
Query: 1079 YLIDVVLPLP-PLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTAD 1137
Y + L + V LI+ RKI + +++ V L
Sbjct: 296 YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERK--EYIQLV--EQLRNTV 351
Query: 1138 GIVIDSTGRKIYWTDGGRNSIEVAELDGR-NRKVLVWTGLDSPRAIALHYEYGYMFWSDW 1196
+ D +K++W D + +I A +D + R V + + +P AIA+ + Y ++W+D
Sbjct: 352 ALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD- 410
Query: 1197 GTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFDGHDR 1255
S I A +DG R+ + ++ ++ P +A+D + G +YW+D + IE + +G DR
Sbjct: 411 AASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDR 470
Query: 1256 R-TVLSNVPYPYGIV--IVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGL 1306
R V +++ +P GI ++ +YW D K L D N D ++ K+LE L
Sbjct: 471 RPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVD-LNGQDRRIVLKSLEFL 523
Score = 74.5 bits (175), Expect = 3e-12
Identities = 83/332 (25%), Positives = 134/332 (40%), Gaps = 23/332 (6%)
Query: 1290 KTNASDPIVIRKNLEGLMDIRAIQSERVLE---NACGTDNGGCSHLCLRSPLGYTCACPT 1346
K + + I I K D R E + E N C +NGGCSH+C +GY C C
Sbjct: 204 KCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAA 263
Query: 1347 GMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDY 1406
G T +C++ I Q D+ V +
Sbjct: 264 GFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGK----- 318
Query: 1407 HWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKV 1466
+ +IF D IR I + + + ++L L D A ++W D K
Sbjct: 319 --EPSLIFTNRRD---IRKIGLERKEYIQLV--EQLRNTVALDADIAAQKLFWADLSQKA 371
Query: 1467 IEVARLDGS-SRKV-LITGLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIV 1524
I A +D R V +I + P A+A+ +YW+D I + LDG++R+ +
Sbjct: 372 IFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD-AASKTISVATLDGTKRKFLF 430
Query: 1525 QVDLGFPNGLTIDYKERRLYWTD-ALKDRIDTSDLNGQHRVQLV-PDAKNPFGMT--QFK 1580
DL P + +D +YW+D +I+ + +NG R LV D + P G+T K
Sbjct: 431 NSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIK 490
Query: 1581 DYIYWTDWYKKSIIRADKRTGKNITLIRTNLE 1612
+YW D K ++ + G++ ++ +LE
Sbjct: 491 SRLYWLD-SKLHMLSSVDLNGQDRRIVLKSLE 521
Score = 39.9 bits (89), Expect = 0.081
Identities = 18/36 (50%), Positives = 23/36 (63%), Gaps = 3/36 (8%)
Query: 157 SCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDE 192
+C HE + C ST+ CI + W+CD D DC D SDE
Sbjct: 71 TCGAHEFQ--C-STSSCIPISWVCDDDADCSDQSDE 103
>Z75190-1|CAA99509.1| 699|Homo sapiens apolipoprotein E receptor 2
906 protein.
Length = 699
Score = 369 bits (909), Expect = e-101
Identities = 193/530 (36%), Positives = 284/530 (53%), Gaps = 29/530 (5%)
Query: 247 AANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNA 306
AA+P P + C + F+C+N +C+P ++CD D+DC D +DED CP +C
Sbjct: 33 AADPLLGGQGPAK--ECEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKK--TCAD 88
Query: 307 GEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCA--DRRCVLKTWL 364
+F C++G CI ERW+CD E +C DG DE + C ++ +C +CV +W
Sbjct: 89 SDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTK-QVCPAEKLSCGPTSHKCVPASWR 147
Query: 365 CDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE 424
CDG +DC G DE C S TCR E + CV C+ +DCP G DE
Sbjct: 148 CDGEKDCEGGADEAGCATSLG----TCRGDEFQCGDG--TCVLAIKHCNQEQDCPDGSDE 201
Query: 425 ERC--PLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-V 481
C L C +C G C CP GF L + K +C DIDEC +DP
Sbjct: 202 AGCLQGLNECLHNNGGCSHICTDLKIGFE-CTCPAGFQLLDQK-TCGDIDEC---KDPDA 256
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPT-GESPTLLFSNRIGIRQVWLTGDNYMSV 540
CSQ C N G F+C C G + ++CK G+SP+L+F+NR + NY +
Sbjct: 257 CSQICVNYKGYFKCECYPGCEMDLLTKNCKAAAGKSPSLIFTNRTSAEDRPVKR-NYSRL 315
Query: 541 VKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNT----KNMSDVIRWGLETPAGVAVD 596
+ L N VALD ++W + + R I A M+ K +I L +P G+AVD
Sbjct: 316 IPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEREVLIDEQLHSPEGLAVD 375
Query: 597 WIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKI 656
W+H ++WTDSG + + VAT+DG +R L + +L +PRAIAV P ++W+DWG KI
Sbjct: 376 WVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKI 435
Query: 657 ERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKV--TT 714
E++ ++G R+T++ D I WPNG+T+D ++YW D+K H + F G +R+ + +T
Sbjct: 436 EKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISST 495
Query: 715 KGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDI 764
L HPF + +F+D ++WTD ++I + N+ G+ I + LN P DI
Sbjct: 496 DFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDI 545
Score = 217 bits (529), Expect = 4e-55
Identities = 122/349 (34%), Positives = 187/349 (53%), Gaps = 26/349 (7%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC--ADGPINYLIFAHRVDIRVISLDVP 1078
K+ CS +C+ G C C G +++ K C A G LIF +R D P
Sbjct: 252 KDPDACSQICVNYKGYFKCECYPGCEMDLLTKNCKAAAGKSPSLIFTNRTSAE----DRP 307
Query: 1079 YLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRA----TRLGTHVETVIGNGLH 1134
+ +P LKN + +DV+ +T IYW D RKI A E +I LH
Sbjct: 308 VKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEREVLIDEQLH 367
Query: 1135 TADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWS 1194
+ +G+ +D + IYWTD G +I VA +DG R+ L L PRAIA+ G+M+WS
Sbjct: 368 SPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWS 427
Query: 1195 DWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHD 1254
DWG AKIE++ ++G +R+ +V + I+WPNG+ +D + RLYW D+K+ + S DF G +
Sbjct: 428 DWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGN 487
Query: 1255 RRTVLSN---VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDI-- 1309
R+T++S+ + +P+GI + ++WTD + +A+ A++ N + ++ +NL DI
Sbjct: 488 RKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVI 547
Query: 1310 -RAIQSERVLENACGTD---NGGCSHLCLRSPL------GYTCACPTGM 1348
++ R +AC NGGC +LCL +P YTCACP M
Sbjct: 548 FHELKQPRA-PDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTM 595
Score = 204 bits (499), Expect = 2e-51
Identities = 117/348 (33%), Positives = 186/348 (53%), Gaps = 24/348 (6%)
Query: 1325 DNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLE 1384
D CS +C+ + C C G + T + KS P LIF R S +
Sbjct: 253 DPDACSQICVNYKGYFKCECYPGCEMDLLTKNCKAAAGKS-PS--LIFTNRTSAE----D 305
Query: 1385 SPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESK---TIISQK 1441
P + + + + +KN +A+D I++ DL I S M S+ K +I ++
Sbjct: 306 RPVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEREVLIDEQ 365
Query: 1442 LETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLIT-GLTEPRALALFPAKGYLY 1500
L +P GL VDW+ +IYWTD+ +K I VA +DG R+ L + L+EPRA+A+ P +G++Y
Sbjct: 366 LHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMY 425
Query: 1501 WSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNG 1560
WSDWG+ IE+S L+G RQ +V ++ +PNG+T+D +RLYW D+ ++ + D +G
Sbjct: 426 WSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSG 485
Query: 1561 QHRVQLVPDA---KNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEI 1617
+R L+ +PFG+ F+D ++WTD ++I A++ G I+++ NL +I
Sbjct: 486 GNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDI 545
Query: 1618 KAVSADRQ-HGWNPCK---ESNGGCSHLCL----FRGH--EYICACPD 1655
+Q + C+ + NGGC +LCL H +Y CACPD
Sbjct: 546 VIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPD 593
Score = 171 bits (415), Expect = 3e-41
Identities = 105/320 (32%), Positives = 154/320 (48%), Gaps = 39/320 (12%)
Query: 805 VETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGS----HQTTIVDSNLIWPAGLAFD 860
+ +K+ VALD + +N I+W D+ I AY++ + + ++D L P GLA D
Sbjct: 316 IPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEREVLIDEQLHSPEGLAVD 375
Query: 861 WITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCI 920
W+ IYWTD G I V+ DG R L ++ +PR I V+P G MYWSDWG I
Sbjct: 376 WVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKI 435
Query: 921 ERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN- 979
E++ ++G +R+ L+ + WPNG+ LDL+ R+YW D + + G R LI +
Sbjct: 436 EKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISST 495
Query: 980 --LPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTLGCGKN--------------- 1022
L HPFG+ ++ D+VFWTD + ++I +AN+ G + L N
Sbjct: 496 DFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPR 555
Query: 1023 -----------NGGCSHLCLLKPGGRS------CACPIGIKLNKDGKTCADGPINYLIFA 1065
NGGC +LCL P S CACP + L D K C
Sbjct: 556 APDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRDANEDSKMG 615
Query: 1066 HRVDIRVISLDVPYLIDVVL 1085
V VI + VP ++ +L
Sbjct: 616 STVTAAVIGIIVPIVVIALL 635
Score = 99.5 bits (237), Expect = 9e-20
Identities = 81/282 (28%), Positives = 128/282 (45%), Gaps = 21/282 (7%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVP 1078
C NNGGCSH+C G C CP G +L D KTC D I+ ++
Sbjct: 211 CLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGD--IDECKDPDACSQICVNYKGY 267
Query: 1079 YLIDVV--LPLPPLKNALGVDVDHSTGLIYW--TDTGQRKIQR-ATRLGTHVETVIGNGL 1133
+ + + L S LI+ T R ++R +RL ++ V+ +
Sbjct: 268 FKCECYPGCEMDLLTKNCKAAAGKSPSLIFTNRTSAEDRPVKRNYSRLIPMLKNVVALDV 327
Query: 1134 HTADGIV--IDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYM 1191
A + D + RKIY + S D + R+VL+ L SP +A+ + + ++
Sbjct: 328 EVATNRIYWCDLSYRKIYSAYMDKAS------DPKEREVLIDEQLHSPEGLAVDWVHKHI 381
Query: 1192 FWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDF 1250
+W+D G I A +DG RR + + P +A+D + G +YW+D IE S
Sbjct: 382 YWTDSGNKT-ISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGL 440
Query: 1251 DGHDRRTVLS-NVPYPYGIV--IVGQHIYWTDWKTKALHRAD 1289
+G DR+T++S N+ +P GI ++ Q +YW D K L D
Sbjct: 441 NGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSID 482
Score = 84.6 bits (200), Expect = 3e-15
Identities = 81/297 (27%), Positives = 123/297 (41%), Gaps = 22/297 (7%)
Query: 1320 NACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSIT 1379
N C +NGGCSH+C +G+ C CP G T +CK P+
Sbjct: 209 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD-PDACSQICVNYK-G 266
Query: 1380 YISLESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIIS 1439
Y E ++ L K K + +T+ R + N S +
Sbjct: 267 YFKCECYPGCEMDLLTKNCKAAAGKS-----PSLIFTNRTSAEDRPVK-RNYSR----LI 316
Query: 1440 QKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSS----RKVLI-TGLTEPRALALFP 1494
L+ L V+ N IYW D ++ I A +D +S R+VLI L P LA+
Sbjct: 317 PMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEREVLIDEQLHSPEGLAVDW 376
Query: 1495 AKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTD-ALKDRI 1553
++YW+D G + I + +DG +R+ + +L P + +D +YW+D + +I
Sbjct: 377 VHKHIYWTDSG-NKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKI 435
Query: 1554 DTSDLNGQHRVQLVPD-AKNPFGMT--QFKDYIYWTDWYKKSIIRADKRTGKNITLI 1607
+ S LNG R LV D + P G+T +YW D + D G TLI
Sbjct: 436 EKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLI 492
Score = 82.6 bits (195), Expect = 1e-14
Identities = 53/168 (31%), Positives = 74/168 (44%), Gaps = 24/168 (14%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
CI W CD D+DC D SDE +C KT ++ + + G I
Sbjct: 59 CIPSVWRCDEDDDCLDHSDEDDCP-KKT---CADSDFTCDNGHCIHE------------- 101
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNT--KCVPKDFQCDGDNDCGD 290
R++ ++ D + +T + V C C T KCVP ++CDG+ DC
Sbjct: 102 -RWKCDGEEECPDGSDESEATCTKQV----CPAEKLSCGPTSHKCVPASWRCDGEKDCEG 156
Query: 291 WTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNC 338
DE C G+C EF+C DG C+ C+ E+DC DG DE C
Sbjct: 157 GADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 204
Score = 55.6 bits (128), Expect = 2e-06
Identities = 55/233 (23%), Positives = 102/233 (43%), Gaps = 20/233 (8%)
Query: 680 LTIDYTESKIYWADAKHHVIERA----AFDGRDRRKVTTKGL--PHPFALTLFDDAIYWT 733
L ++ ++IYW D + I A A D ++R + + L P A+ IYWT
Sbjct: 325 LDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEREVLIDEQLHSPEGLAVDWVHKHIYWT 384
Query: 734 DWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESK 793
D K+IS + G L+ P R+ P + +Y D + K
Sbjct: 385 DSGNKTISVATVDGGRRRTLFSRNLSEP-----RAIAVDPLRGFMYW--SDWGDQAKIEK 437
Query: 794 KPIDSLD-MVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSN-- 850
++ +D + + I+ + D S ++W D + ++ +G ++ T++ S
Sbjct: 438 SGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDF 497
Query: 851 LIWPAGLAFDWITDKIYWTDGGTNRI-EVSKSDGSMRTLLAWDHIDKPRDIVV 902
L P G+A DK++WTD I ++ +G ++LA ++++ P DIV+
Sbjct: 498 LSHPFGIAV--FEDKVFWTDLENEAIFSANRLNGLEISILA-ENLNNPHDIVI 547
Score = 35.9 bits (79), Expect = 1.3
Identities = 13/28 (46%), Positives = 16/28 (57%)
Query: 1627 GWNPCKESNGGCSHLCLFRGHEYICACP 1654
G N C +NGGCSH+C + C CP
Sbjct: 207 GLNECLHNNGGCSHICTDLKIGFECTCP 234
Score = 34.7 bits (76), Expect = 3.1
Identities = 26/101 (25%), Positives = 40/101 (39%), Gaps = 8/101 (7%)
Query: 99 DPDDGPLNEGTEDDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSC 158
D DD L+ EDD T C +F+C + CI +R +C
Sbjct: 67 DEDDDCLDHSDEDDCPKKT-CADSDFTCD-NGHCI--HERWKCDGEEECPDGSDESEATC 122
Query: 159 DEH----ENRTICHSTNVCIALEWLCDGDNDCGDFSDEINC 195
+ E + +++ C+ W CDG+ DC +DE C
Sbjct: 123 TKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
>U04441-1|AAB02882.1| 1751|Homo sapiens glycoprotein 330 protein.
Length = 1751
Score = 367 bits (903), Expect = e-100
Identities = 189/520 (36%), Positives = 275/520 (52%), Gaps = 29/520 (5%)
Query: 263 CAEIDFECKNTK-----CVPKDFQCDGDNDCGDWTDE-DSCPMVPGSCNAGEFKCNDGKC 316
C++ +F C N + C+P+ + DGD DC D DE +C +C+ EF C G C
Sbjct: 245 CSDSEFPCVNDRPPDRRCIPQSWPPDGDVDCTDGHDEIQNCTR--RTCSENEFTCGYGLC 302
Query: 317 IPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGED 376
IP+ +RCD DC D DE C + C +++TC + RC+ KT++CD DC +G D
Sbjct: 303 IPKIFRCDRHNDCGDYSDERGCL---YQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSD 359
Query: 377 EMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCS-- 434
E+ C + TC P E N C+ +C+ + DC DE+ C + +C
Sbjct: 360 ELMH--LCHTPEPTCPPHEFKCDNG--RCIEMMKLCNHLDDCLDNSDEKGCGIN-ECHDP 414
Query: 435 AEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFR 494
+ C+ C T C+C G+ L DK +C DIDEC E VCSQ C N +GS+
Sbjct: 415 SISGCDHNCTDTLTSFY-CSCRPGYKLMSDKRTCVDIDECT-EMPFVCSQKCENVIGSYI 472
Query: 495 CGCMTGYILRPDERSCKPTGE-SPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYH 553
C C GY+ PD ++C+ P L+FSNR +R + + G Y +++GL N VALD+
Sbjct: 473 CKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFD 532
Query: 554 YEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVE 613
+K ++W + +VI +N N +I L +AVDW+ L+W D+ +
Sbjct: 533 RVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLF 592
Query: 614 VATLDGSKRAVLV-----AND---LDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDK 665
V+ L+G R +L AN+ D PR +A+HP ++W DWG I R MDG
Sbjct: 593 VSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTN 652
Query: 666 RKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTL 725
+ +I ++ WPNG+TIDYT +YWADA IE + +G R V LPHPFA+T+
Sbjct: 653 KSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITI 712
Query: 726 FDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDIH 765
F+D IYWTDW+T+++ NK G QT+ + P DIH
Sbjct: 713 FEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIH 752
Score = 305 bits (748), Expect = 1e-81
Identities = 175/513 (34%), Positives = 261/513 (50%), Gaps = 33/513 (6%)
Query: 259 ELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCP-MVPGS--CNAGEFKCNDGK 315
E+ C F+C + V + +CDG DC D +DE CP P C A F+C +
Sbjct: 1092 EMRTCHPEYFQCTSGHRVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKNHV 1151
Query: 316 CIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGE 375
CIP W+CD + DC DG DE + S + + C + RC+ +C+GV DC +G
Sbjct: 1152 CIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDGT 1211
Query: 376 DEMNCEVSCEE-DQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPL-KRKC 433
DE E C + C E+ N +C+ +VCD DC DE C K +
Sbjct: 1212 DE--TEEHCRKPTPKPCTEYEYKCGNG--HCIPHDNVCDDADDCGDWSDELGCNKGKERT 1267
Query: 434 SAEEKCEKLCITTYDGHAACACPMGF-LLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGS 492
AE CE+ C +G C+C GF D+ SC DI+EC EQ C Q C NT GS
Sbjct: 1268 CAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINEC--EQFGTCPQHCRNTKGS 1325
Query: 493 FRCGCMTGYILRPDE--RSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVAL 550
+ C C G+ D + C G SP LL + + IR+ L+ + + ++ A+
Sbjct: 1326 YECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQDEEYIQAV 1385
Query: 551 DYHYEKK-----LVFWS----ENNLRVIRVA-----QMNTKNMSDVIRWGLE---TPAGV 593
DY ++ + +V+++ + I+ A + N+ + L+ P G+
Sbjct: 1386 DYDWDPEDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGI 1445
Query: 594 AVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPN 653
AVDW+ ++W+D +R+EVA LDG R L++ DLD+P AIAV+P L+FWTDWG
Sbjct: 1446 AVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKE 1505
Query: 654 PKIERADMDGDKRKTVIYDEIFWPNGLTIDY-TESKIYWADAKHHVIERAAFDGRDRRKV 712
PK+E A M+G+ ++++++ WP GL+IDY +IYW+D K VIE +DG DRR V
Sbjct: 1506 PKLESAWMNGEDPNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRR-V 1564
Query: 713 TTKGLPHPFALTLFDDAIYWTDWHTKSISTVNK 745
K +P++L +F+D +YW + NK
Sbjct: 1565 IAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNK 1597
Score = 242 bits (593), Expect = 7e-63
Identities = 126/335 (37%), Positives = 183/335 (54%), Gaps = 18/335 (5%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPI--NYLIFAHRVDIRVISLDVPYLIDV 1083
CS C G C C G DGKTC YLIF++R +R +++D Y +
Sbjct: 460 CSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTID-GYFYSL 518
Query: 1084 VLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDS 1143
+L L N + +D D +YW DT ++ I+R T+ ET+I + L A+ + +D
Sbjct: 519 ILE--GLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDW 576
Query: 1144 TGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDS--------PRAIALHYEYGYMFWSD 1195
RK+YW D + + V++L+G +R++L +D+ PR +ALH +YGY++W+D
Sbjct: 577 VSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWAD 636
Query: 1196 WGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDR 1255
WG A I R MDG N+ VI+ K++WPNG+ ID LYW DA + IE SD +GH R
Sbjct: 637 WGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHR 696
Query: 1256 RTVLSN-VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQS 1314
TV +P+P+ I I IYWTDW T+ + + +K + S+ + DI
Sbjct: 697 HTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHP 756
Query: 1315 ER--VLENACGTDNGGCSHLCLRSP--LGYTCACP 1345
R ++ N CGT+NGGCSHLCL P G+TC CP
Sbjct: 757 YRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECP 791
Score = 205 bits (501), Expect = 1e-51
Identities = 115/341 (33%), Positives = 177/341 (51%), Gaps = 20/341 (5%)
Query: 1329 CSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQ 1388
CS C Y C C G + + +T ++ S+ E +LIF+ R + ++++
Sbjct: 460 CSQKCENVIGSYICKCAPG--YLREPDGKTCRQ-NSNIEPYLIFSNRYYLRNLTIDG--- 513
Query: 1389 WDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGL 1448
+ +L ++ + N +A+D+ K +++ D VI + + N + +TII+ +L L
Sbjct: 514 YFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFL-NKTNKETIINHRLPAAESL 572
Query: 1449 GVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITGLTE---------PRALALFPAKGYL 1499
VDW++ +YW D + V+ L+G R++L + PR LAL P GYL
Sbjct: 573 AVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYL 632
Query: 1500 YWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLN 1559
YW+DWG YI R +DG+ + +I+ L +PNG+TIDY LYW DA I+ SDL
Sbjct: 633 YWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLE 692
Query: 1560 GQHRVQLVPDA-KNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIK 1618
G HR + A +PF +T F+D IYWTDW +++ + +K G N + +I
Sbjct: 693 GHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIH 752
Query: 1619 AVSADRQH-GWNPCKESNGGCSHLCLFR--GHEYICACPDD 1656
RQ NPC +NGGCSHLCL + G + C CPDD
Sbjct: 753 VYHPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPDD 793
Score = 200 bits (488), Expect = 4e-50
Identities = 98/281 (34%), Positives = 157/281 (55%), Gaps = 34/281 (12%)
Query: 796 IDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPA 855
ID + +E + + VALD+D+ ++W D ++ I R +LN +++ TI++ L
Sbjct: 511 IDGYFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAE 570
Query: 856 GLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHID--------KPRDIVVNPEGG 907
LA DW++ K+YW D + + VS +G R +LA +D PR + ++P+ G
Sbjct: 571 SLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYG 630
Query: 908 VMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYAN 967
+YW+DWG I R MDG N+ +I ++ WPNG+ +D ++ +YW D IEY++
Sbjct: 631 YLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSD 690
Query: 968 LDGTGRTKLIEN-LPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTL--------- 1017
L+G R + + LPHPF + ++ D ++WTDW+T++++ NK G+ R+TL
Sbjct: 691 LEGHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFD 750
Query: 1018 --------------GCGKNNGGCSHLCLLKPGGR--SCACP 1042
CG NNGGCSHLCL+KPGG+ +C CP
Sbjct: 751 IHVYHPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECP 791
Score = 200 bits (487), Expect = 5e-50
Identities = 169/600 (28%), Positives = 261/600 (43%), Gaps = 72/600 (12%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIAL 226
CH++N+CI +LCDGDNDCGD SDE T+ S+ G I
Sbjct: 125 CHNSNICIPRVYLCDGDNDCGDNSDEN--PTYCTTHTCSSSEFQCASGRCIP-------- 174
Query: 227 TKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDN 286
+ + E+ C D + P S + C +F+C +C+P ++ CDGDN
Sbjct: 175 -QTFGICDQETDC----FDASDEPSSCGHSE---RTCLSDEFKCDGGRCIPNEWICDGDN 226
Query: 287 DCGDWTDEDSCPMVPG-SCNAGEFKC-----NDGKCIPERWRCDNERDCADGGDEL-NCK 339
DCGD +DED +C+ EF C D +CIP+ W D + DC DG DE+ NC
Sbjct: 227 DCGDMSDEDKRHQCQNQNCSDSEFPCVNDRPPDRRCIPQSWPPDGDVDCTDGHDEIQNC- 285
Query: 340 PNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC-EVSCEEDQYTCRPQEHLM 398
+ R CS +E+TC C+ K + CD DC + DE C +C+++Q+TC+
Sbjct: 286 --TRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQ------ 337
Query: 399 SNAFRNCVNRKHVCDGMKDCPRGDDE--ERCPL-KRKCSAEE-KCEK-LCITTYDGHAAC 453
N C+++ VCD DC G DE C + C E KC+ CI + C
Sbjct: 338 -NG--RCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCI---EMMKLC 391
Query: 454 ACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPT 513
L D+ C I+EC C C++T+ SF C C GY L D+R+C
Sbjct: 392 NHLDDCLDNSDEKGC-GINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDI 450
Query: 514 GESPTLLF------SNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLVFWSENNLR 567
E + F N IG + Y+ G + + E L+F + LR
Sbjct: 451 DECTEMPFVCSQKCENVIG-SYICKCAPGYLREPDG--KTCRQNSNIEPYLIFSNRYYLR 507
Query: 568 VIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVA 627
+ + +I GL+ + D + L+W D+ + +E L+ + + ++
Sbjct: 508 NLTI----DGYFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIIN 563
Query: 628 NDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRK-----TVIYDEIFW---PNG 679
+ L ++AV ++W D + +D++G R+ V + F P G
Sbjct: 564 HRLPAAESLAVDWVSRKLYWLD-ARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRG 622
Query: 680 LTIDYTESKIYWADAKHHV-IERAAFDGRDRRKVTTKGLPHPFALTL--FDDAIYWTDWH 736
L + +YWAD H I R DG ++ + + L P +T+ +D +YW D H
Sbjct: 623 LALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAH 682
Score = 180 bits (437), Expect = 6e-44
Identities = 116/361 (32%), Positives = 180/361 (49%), Gaps = 30/361 (8%)
Query: 1327 GGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEE-FLIFATRGSITYISLES 1385
G C C + Y C C G S +D+ K+C + L+ I +L S
Sbjct: 1313 GTCPQHCRNTKGSYECVCADGFT---SMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSS 1369
Query: 1386 PEQWDVTLPVKEVKNTIAVDYHWD-----LKMIFYT----DLDLNVIRSINMTNMSESKT 1436
E++ L +E AVDY WD L +++YT I+ + N +
Sbjct: 1370 -ERFSEYLQDEEYIQ--AVDYDWDPEDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRN 1426
Query: 1437 IISQKLET-------PNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLI-TGLTEPR 1488
+ Q+++ P+G+ VDW+ +IYW+D ++K IEVA+LDG RK LI T L +P
Sbjct: 1427 NLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPA 1486
Query: 1489 ALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDY-KERRLYWTD 1547
A+A+ P G ++W+DWG+ P +E ++++G I+V DLG+P GL+IDY R+YW+D
Sbjct: 1487 AIAVNPKLGLMFWTDWGKEPKLESAWMNGEDPNILVFEDLGWPTGLSIDYLNNDRIYWSD 1546
Query: 1548 ALKDRIDTSDLNGQHRVQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADK--RTGKNIT 1605
+D I+T +G R + +A NP+ + F+D +YW K + + +K + K T
Sbjct: 1547 FKEDVIETIKYDGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKT 1606
Query: 1606 LIRTNLEMAMEIKAVSADRQHGWNPCKESNGGCSHLCLFRGHEYICACPDDPDHVECSTV 1665
L+ + I + N CK+ CSHLCL R Y CACP +E ST
Sbjct: 1607 LVVNPWLTQVRIFHQLRYNKSVPNLCKQI---CSHLCLLRPGGYSCACPQGSSFIEGSTT 1663
Query: 1666 K 1666
+
Sbjct: 1664 E 1664
Score = 169 bits (411), Expect = 8e-41
Identities = 119/357 (33%), Positives = 170/357 (47%), Gaps = 29/357 (8%)
Query: 1024 GGCSHLCLLKPGGRSCACPIGIKLNKD--GKTCA-DGPINYLIFAHRVDIRVISLDVPYL 1080
G C C G C C G D GK CA +G L+ V IR +L
Sbjct: 1313 GTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERF 1372
Query: 1081 IDVVLPLPPLKNALGVDVD-HSTGL--IYWTDTGQRK----IQRA---------TRLGTH 1124
+ + ++ A+ D D GL +Y+T G+ I+RA L
Sbjct: 1373 SEYLQDEEYIQ-AVDYDWDPEDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQE 1431
Query: 1125 VETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIAL 1184
V+ + + DGI +D GR IYW+D IEVA+LDGR RK L+ T LD P AIA+
Sbjct: 1432 VDLKLKYVMQP-DGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAV 1490
Query: 1185 HYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEG-RLYWNDAKIL 1243
+ + G MFW+DWG K+E A M+G + ++V + WP GL+ID + R+YW+D K
Sbjct: 1491 NPKLGLMFWTDWGKEPKLESAWMNGEDPNILVFEDLGWPTGLSIDYLNNDRIYWSDFKED 1550
Query: 1244 TIESSDFDGHDRRTVLSNVPYPYGIVIVGQHIYWTDWKTKALHRADK---TNASDPIVIR 1300
IE+ +DG DRR + PY + I +YW + + + +K +V+
Sbjct: 1551 VIETIKYDGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVN 1610
Query: 1301 KNLEGLMDIRAIQSERVLENACGTDNGGCSHLCLRSPLGYTCACPTGMPF-EKSTTD 1356
L + ++ + + N C CSHLCL P GY+CACP G F E STT+
Sbjct: 1611 PWLTQVRIFHQLRYNKSVPNLC---KQICSHLCLLRPGGYSCACPQGSSFIEGSTTE 1664
Score = 157 bits (380), Expect = 4e-37
Identities = 85/228 (37%), Positives = 120/228 (52%), Gaps = 22/228 (9%)
Query: 854 PAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSD 913
P G+A DW+ IYW+D RIEV+K DG R L +D+P I VNP+ G+M+W+D
Sbjct: 1442 PDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTD 1501
Query: 914 WGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHN-RIYWTDGGNKTIEYANLDGTG 972
WG P +E A M+G + L+F + WP GL++D ++N RIYW+D IE DGT
Sbjct: 1502 WGKEPKLESAWMNGEDPNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTD 1561
Query: 973 RTKLIENLPHPFGLDLYGDEVFWTDWDTQSIQAANK-DTGAKRRTLGCG----------- 1020
R + + +P+ LD++ D+++W + + NK G K +TL
Sbjct: 1562 RRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFHQ 1621
Query: 1021 -KNNGG--------CSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPI 1059
+ N CSHLCLL+PGG SCACP G + T D I
Sbjct: 1622 LRYNKSVPNLCKQICSHLCLLRPGGYSCACPQGSSFIEGSTTECDAAI 1669
Score = 137 bits (331), Expect = 4e-31
Identities = 64/186 (34%), Positives = 98/186 (52%), Gaps = 11/186 (5%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C +++C N +C+P+ +QCD NDC D +DEDS +C G+F+C +G+CIP+ W+
Sbjct: 891 CDSNEWQCANKRCIPESWQCDSFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWK 950
Query: 323 CDNERDCADGGDE--LNCKPNSIRNCSLDEYTC-ADRRCVLKTWLCDGVRDCTNGEDEMN 379
CD + DC D DE C ++ + E++C + RC+ K +C+GV DC + DE
Sbjct: 951 CDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQG 1010
Query: 380 CEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKC 439
CE + TC P +C+ + CDG DC DEE C + +E +C
Sbjct: 1011 CE------ERTCHPVGDFRCKN-HHCIPLRWKCDGQNDCGDNSDEENCAPRECTESEFRC 1063
Query: 440 -EKLCI 444
+ CI
Sbjct: 1064 VNQQCI 1069
Score = 136 bits (328), Expect = 9e-31
Identities = 134/519 (25%), Positives = 212/519 (40%), Gaps = 57/519 (10%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDC-GDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
C E +F C N +C+P + CD ND GD +DE C M +C+ F+C G +
Sbjct: 1056 CTESEFRCVNQQCIPSRWICDHYNDLWGDNSDERDCEM--RTCHPEYFQCTSGHRVHSEL 1113
Query: 322 RCDNERDCADGGDELNCKPNSIRN---CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEM 378
+CD DC D DE +C P + C + C + C+ W CDG DC +G DE
Sbjct: 1114 KCDGSADCLDASDEADC-PTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDE- 1171
Query: 379 NCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDD--EERC--PLKRKCS 434
E+ D P N C+ VC+G+ DC G D EE C P + C+
Sbjct: 1172 --ELHLCLDVPCNSPNRFRCDN--NRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCT 1227
Query: 435 A-EEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSN-TVGS 492
E KC +D A G D+ C E ++ +C Q C+ G
Sbjct: 1228 EYEYKCGNGHCIPHDNVCDDADDCGDW--SDELGCNKGKERTCAEN-ICEQNCTQLNEGG 1284
Query: 493 FRCGCMTGYILRPDERS-------CKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLH 545
F C C G+ +R+ C+ G P + + V G MS G
Sbjct: 1285 FICSCTAGFETNVFDRTSCLDINECEQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKR 1344
Query: 546 NAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHD----- 600
A + +N+R IR ++++ S+ ++ E V DW +
Sbjct: 1345 CAAE-----GSSPLLLLPDNVR-IRKYNLSSERFSEYLQ-DEEYIQAVDYDWDPEDIGLS 1397
Query: 601 LLFWTDSG-------TRRVEVATLDGSKRAVLVANDLD-----KPRAIAVHPGDALVFWT 648
++++T G +R + + + ++ DL +P IAV ++W+
Sbjct: 1398 VVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWS 1457
Query: 649 DWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWAD-AKHHVIERAAFDGR 707
D N +IE A +DG RK +I ++ P + ++ ++W D K +E A +G
Sbjct: 1458 D-VKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKLESAWMNGE 1516
Query: 708 DRRKVTTKGLPHPFALT---LFDDAIYWTDWHTKSISTV 743
D + + L P L+ L +D IYW+D+ I T+
Sbjct: 1517 DPNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETI 1555
Score = 134 bits (323), Expect = 4e-30
Identities = 86/274 (31%), Positives = 125/274 (45%), Gaps = 37/274 (13%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
C+ + CD NDCGD SDE C L NA+ +
Sbjct: 49 CVQYSYRCDYYNDCGDGSDETGC-------LFRDCNATTEF------------MCNNRRC 89
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTK-CVPKDFQCDGDNDCGDW 291
I E C +DN + ++ + C +C N+ C+P+ + CDGDNDCGD
Sbjct: 90 IPREFIC--NGVDNCHDNNTSDEKNCPDRTCQSGYPKCHNSNICIPRVYLCDGDNDCGDN 147
Query: 292 TDEDSCPMVPGSCNAGEFKCNDGKCIPERWR-CDNERDCADGGDELNCKPNSIRNCSLDE 350
+DE+ +C++ EF+C G+CIP+ + CD E DC D DE + +S R C DE
Sbjct: 148 SDENPTYCTTHTCSSSEFQCASGRCIPQTFGICDQETDCFDASDEPSSCGHSERTCLSDE 207
Query: 351 YTCADRRCVLKTWLCDGVRDCTNGEDE---MNCE-VSCEEDQYTC---RPQEHLMSNAFR 403
+ C RC+ W+CDG DC + DE C+ +C + ++ C RP + R
Sbjct: 208 FKCDGGRCIPNEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFPCVNDRPPD-------R 260
Query: 404 NCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE 437
C+ + DG DC G DE + +R CS E
Sbjct: 261 RCIPQSWPPDGDVDCTDGHDEIQNCTRRTCSENE 294
Score = 132 bits (320), Expect = 8e-30
Identities = 84/255 (32%), Positives = 118/255 (46%), Gaps = 28/255 (10%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
CI W CD DNDCGD SDE + +S ++ D N T T +
Sbjct: 944 CIPQAWKCDVDNDCGDHSDEP----------IEECMSSAHLCD---NFTEFSCKTNYRCI 990
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEI-DFECKNTKCVPKDFQCDGDNDCGDW 291
++ + C +D+ + ++ Q E C + DF CKN C+P ++CDG NDCGD
Sbjct: 991 PKW-AVC--NGVDDCRD--NSDEQGCEERTCHPVGDFRCKNHHCIPLRWKCDGQNDCGDN 1045
Query: 292 TDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDC-ADGGDELNCKPNSIRNCSLDE 350
+DE++C P C EF+C + +CIP RW CD+ D D DE +C+ +R C +
Sbjct: 1046 SDEENC--APRECTESEFRCVNQQCIPSRWICDHYNDLWGDNSDERDCE---MRTCHPEY 1100
Query: 351 YTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKH 410
+ C V CDG DC + DE +C + Y C+ N C+
Sbjct: 1101 FQCTSGHRVHSELKCDGSADCLDASDEADCPTRFPDGAY-CQATMFECKN--HVCIPPYW 1157
Query: 411 VCDGMKDCPRGDDEE 425
CDG DC G DEE
Sbjct: 1158 KCDGDDDCGDGSDEE 1172
Score = 118 bits (284), Expect = 2e-25
Identities = 61/178 (34%), Positives = 92/178 (51%), Gaps = 17/178 (9%)
Query: 268 FECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNER 327
F C N +C+ ++++CD DN CGD +DE +C+ F C +G+C+ +RCD
Sbjct: 1 FTCSNGRCISEEWKCDNDNGCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRCDYYN 60
Query: 328 DCADGGDELNCKPNSIRNC-SLDEYTCADRRCVLKTWLCDGVRDC--TNGEDEMNC-EVS 383
DC DG DE C R+C + E+ C +RRC+ + ++C+GV +C N DE NC + +
Sbjct: 61 DCGDGSDETGC---LFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDRT 117
Query: 384 CEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEE--RCPLKRKCSAEEKC 439
C+ C SN C+ R ++CDG DC DE C S+E +C
Sbjct: 118 CQSGYPKCH-----NSNI---CIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQC 167
Score = 118 bits (283), Expect = 3e-25
Identities = 82/262 (31%), Positives = 118/262 (45%), Gaps = 33/262 (12%)
Query: 169 STNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTK 228
S CI+ EW CD DN CGD SDE+ V P+A N G + +
Sbjct: 4 SNGRCISEEWKCDNDNGCGDGSDEME-SVCALHTCSPTAFTCAN-GRCV----------Q 51
Query: 229 PTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDC 288
+ Y + C + + R N E M C N +C+P++F C+G ++C
Sbjct: 52 YSYRCDYYNDCGDGSDETGCLFRDC-NATTEFM--------CNNRRCIPREFICNGVDNC 102
Query: 289 GD--WTDEDSCPMVPGSCNAGEFKC-NDGKCIPERWRCDNERDCADGGDELNCKPNSIRN 345
D +DE +CP +C +G KC N CIP + CD + DC D DE N +
Sbjct: 103 HDNNTSDEKNCP--DRTCQSGYPKCHNSNICIPRVYLCDGDNDCGDNSDE-NPTYCTTHT 159
Query: 346 CSLDEYTCADRRCVLKTW-LCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRN 404
CS E+ CA RC+ +T+ +CD DC + DE + SC + TC E
Sbjct: 160 CSSSEFQCASGRCIPQTFGICDQETDCFDASDEPS---SCGHSERTCLSDEFKCDGG--R 214
Query: 405 CVNRKHVCDGMKDCPRGDDEER 426
C+ + +CDG DC DE++
Sbjct: 215 CIPNEWICDGDNDCGDMSDEDK 236
Score = 108 bits (260), Expect = 2e-22
Identities = 52/171 (30%), Positives = 80/171 (46%), Gaps = 4/171 (2%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C F+C + C C+ +C D +DED C++ E++C + +CIPE W+
Sbjct: 850 CRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQ 909
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV 382
CD+ DC D DE + + R C ++ CA+ RC+ + W CD DC + DE E
Sbjct: 910 CDSFNDCEDNSDE-DSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEE- 967
Query: 383 SCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKC 433
C + C C+ + VC+G+ DC DE+ C +R C
Sbjct: 968 -CMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCE-ERTC 1016
Score = 95.1 bits (226), Expect = 2e-18
Identities = 63/189 (33%), Positives = 91/189 (48%), Gaps = 19/189 (10%)
Query: 260 LMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNA-GEFKCNDGKCIP 318
L C+ F C N +CV ++CD NDCGD +DE C + CNA EF CN+ +CIP
Sbjct: 34 LHTCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDETGC--LFRDCNATTEFMCNNRRCIP 91
Query: 319 ERWRCDNERDCADG--GDELNCKPNSIRNCSLDEYTCADRR-CVLKTWLCDGVRDCTNGE 375
+ C+ +C D DE NC P+ R C C + C+ + +LCDG DC +
Sbjct: 92 REFICNGVDNCHDNNTSDEKNC-PD--RTCQSGYPKCHNSNICIPRVYLCDGDNDCGDNS 148
Query: 376 DEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKH-VCDGMKDC-PRGDDEERC-PLKRK 432
DE C +TC E ++ C+ + +CD DC D+ C +R
Sbjct: 149 DEN--PTYC--TTHTCSSSEFQCASG--RCIPQTFGICDQETDCFDASDEPSSCGHSERT 202
Query: 433 CSAEE-KCE 440
C ++E KC+
Sbjct: 203 CLSDEFKCD 211
Score = 91.1 bits (216), Expect = 3e-17
Identities = 73/277 (26%), Positives = 113/277 (40%), Gaps = 44/277 (15%)
Query: 254 WNQPVELMRCAEIDFECKNTKCVP---KDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFK 310
+ QP+ C + C + + K F C+ +D S +P C++ +F
Sbjct: 757 YRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMP-MCSSTQFL 815
Query: 311 C-NDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVR 369
C N+ KCIP W+CD ++DC+DG DEL P R C L ++ C+D C LC+ +
Sbjct: 816 CANNEKCIPIWWKCDGQKDCSDGSDELALCPQ--RFCRLGQFQCSDGNCTSPQTLCNAHQ 873
Query: 370 DCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEE---- 425
+C +G DE + CE + C E +N + C+ CD DC DE+
Sbjct: 874 NCPDGSDE--DRLLCE--NHHCDSNEWQCAN--KRCIPESWQCDSFNDCEDNSDEDSSHC 927
Query: 426 ----------RC------PLKRKCSAEEKC-----EKL--CITT---YDGHAACACPMGF 459
RC P KC + C E + C+++ D +C +
Sbjct: 928 ASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNY 987
Query: 460 LLAEDKYSCRDIDECMYEQDPV-CSQTCSNTVGSFRC 495
C +D+C D C + + VG FRC
Sbjct: 988 RCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRC 1024
Score = 63.7 bits (148), Expect = 6e-09
Identities = 42/180 (23%), Positives = 85/180 (47%), Gaps = 8/180 (4%)
Query: 796 IDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPA 855
+ +D+ + +A+DW I+W+DV+ I A L+G ++ ++ ++L PA
Sbjct: 1429 VQEVDLKLKYVMQPDGIAVDW--VGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPA 1486
Query: 856 GLAFDWITDKIYWTDGGTN-RIEVSKSDGSMRTLLAWDHIDKPRDIVVN-PEGGVMYWSD 913
+A + ++WTD G ++E + +G +L ++ + P + ++ +YWSD
Sbjct: 1487 AIAVNPKLGLMFWTDWGKEPKLESAWMNGEDPNILVFEDLGWPTGLSIDYLNNDRIYWSD 1546
Query: 914 WGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGR 973
+ IE DG +R+ + M N +LD+ +++YW + N G G+
Sbjct: 1547 F-KEDVIETIKYDGTDRRVIAKEAM---NPYSLDIFEDQLYWISKEKGEVWKQNKFGQGK 1602
Score = 63.3 bits (147), Expect = 8e-09
Identities = 39/157 (24%), Positives = 81/157 (51%), Gaps = 6/157 (3%)
Query: 559 VFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTR-RVEVATL 617
++WS+ + I VA+++ + +I L+ PA +AV+ L+FWTD G ++E A +
Sbjct: 1454 IYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKLESAWM 1513
Query: 618 DGSKRAVLVANDLDKPRAIAV-HPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFW 676
+G +LV DL P +++ + + ++W+D+ IE DG R+ + + +
Sbjct: 1514 NGEDPNILVFEDLGWPTGLSIDYLNNDRIYWSDF-KEDVIETIKYDGTDRRVIAKEAM-- 1570
Query: 677 PNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVT 713
N ++D E ++YW + + + G+ +++ T
Sbjct: 1571 -NPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKT 1606
Score = 39.5 bits (88), Expect = 0.11
Identities = 15/22 (68%), Positives = 17/22 (77%)
Query: 171 NVCIALEWLCDGDNDCGDFSDE 192
+VCI W CDGD+DCGD SDE
Sbjct: 1150 HVCIPPYWKCDGDDDCGDGSDE 1171
Score = 37.1 bits (82), Expect = 0.57
Identities = 18/40 (45%), Positives = 23/40 (57%), Gaps = 3/40 (7%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINC 195
R+C E+E C +CI + CD NDCGD+SDE C
Sbjct: 288 RTCSENE--FTC-GYGLCIPKIFRCDRHNDCGDYSDERGC 324
Score = 37.1 bits (82), Expect = 0.57
Identities = 15/32 (46%), Positives = 22/32 (68%), Gaps = 1/32 (3%)
Query: 162 ENRTICHSTNVCIALEWLCDGDNDCGDFSDEI 193
+N+ C + CI+ ++CD DNDCGD SDE+
Sbjct: 331 QNQFTCQNGR-CISKTFVCDEDNDCGDGSDEL 361
Score = 36.3 bits (80), Expect = 1.00
Identities = 16/41 (39%), Positives = 27/41 (65%), Gaps = 3/41 (7%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCD 196
+ C E+E + C + + CI + +CD +DCGD+SDE+ C+
Sbjct: 1224 KPCTEYEYK--CGNGH-CIPHDNVCDDADDCGDWSDELGCN 1261
Score = 34.7 bits (76), Expect = 3.1
Identities = 18/43 (41%), Positives = 23/43 (53%), Gaps = 4/43 (9%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDC-GDFSDEINCDV 197
R C E E R + CI W+CD ND GD SDE +C++
Sbjct: 1054 RECTESEFRCV---NQQCIPSRWICDHYNDLWGDNSDERDCEM 1093
>D86407-1|BAA21824.1| 963|Homo sapiens ApoER2 protein.
Length = 963
Score = 366 bits (901), Expect = e-100
Identities = 195/524 (37%), Positives = 282/524 (53%), Gaps = 37/524 (7%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND---GKCIPE 319
CA +F+C N C+ F CDGD+DCGD +DE C +C EF+C G CIPE
Sbjct: 167 CAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC--ADPACGPREFRCGGDGGGACIPE 224
Query: 320 RWRCDNERDCADGGDE---LNCKP-----NSIRNCS-LDEYTCADRRCVLKTWLCDGVRD 370
RW CD + DC D DE L +P ++ C+ + ++ C CV W CDG RD
Sbjct: 225 RWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATVSQFACRSGECVHLGWRCDGDRD 284
Query: 371 CTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC--P 428
C + DE +C + TCR E + CV C+ +DCP G DE C
Sbjct: 285 CKDKSDEADCPLG------TCRGDEFQCGDG--TCVLAIKHCNQEQDCPDGSDEAGCLQG 336
Query: 429 LKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQTCS 487
L C +C G C CP GF L + K +C DIDEC +DP CSQ C
Sbjct: 337 LNECLHNNGGCSHICTDLKIGFE-CTCPAGFQLLDQK-TCGDIDEC---KDPDACSQICV 391
Query: 488 NTVGSFRCGCMTGYILRPDERSCKPTG-ESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHN 546
N G F+C C GY + ++CK G +SP+L+F+NR +R++ L NY ++ L N
Sbjct: 392 NYKGYFKCECYPGYEMDLLTKNCKAAGGKSPSLIFTNRYEVRRIDLVKRNYSRLIPMLKN 451
Query: 547 AVALDYHYEKKLVFWSENNLRVIRVAQMNT----KNMSDVIRWGLETPAGVAVDWIHDLL 602
VALD ++W + + R I A M+ K +I L +P G+AVDW+H +
Sbjct: 452 VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 511
Query: 603 FWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMD 662
+WTDSG + + VAT+DG +R L + +L +PRAIAV P ++W+DWG KIE++ ++
Sbjct: 512 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 571
Query: 663 GDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKV--TTKGLPHP 720
G R+T++ D I WPNG+T+D ++YW D+K H + F G +R+ + +T L HP
Sbjct: 572 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 631
Query: 721 FALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDI 764
F + +F+D ++WTD ++I + N+ G+ I + LN P DI
Sbjct: 632 FGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDI 675
Score = 221 bits (541), Expect = 1e-56
Identities = 124/349 (35%), Positives = 192/349 (55%), Gaps = 25/349 (7%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC--ADGPINYLIFAHRVDIRVISLDVP 1078
K+ CS +C+ G C C G +++ K C A G LIF +R ++R I L V
Sbjct: 381 KDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAGGKSPSLIFTNRYEVRRIDL-VK 439
Query: 1079 YLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRA----TRLGTHVETVIGNGLH 1134
++P+ LKN + +DV+ +T IYW D RKI A E +I LH
Sbjct: 440 RNYSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH 497
Query: 1135 TADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWS 1194
+ +G+ +D + IYWTD G +I VA +DG R+ L L PRAIA+ G+M+WS
Sbjct: 498 SPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWS 557
Query: 1195 DWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHD 1254
DWG AKIE++ ++G +R+ +V + I+WPNG+ +D + RLYW D+K+ + S DF G +
Sbjct: 558 DWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGN 617
Query: 1255 RRTVLSN---VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDI-- 1309
R+T++S+ + +P+GI + ++WTD + +A+ A++ N + ++ +NL DI
Sbjct: 618 RKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVI 677
Query: 1310 -RAIQSERVLENACGTD---NGGCSHLCLRSPL------GYTCACPTGM 1348
++ R +AC NGGC +LCL +P YTCACP M
Sbjct: 678 FHELKQPRA-PDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTM 725
Score = 206 bits (503), Expect = 6e-52
Identities = 118/350 (33%), Positives = 186/350 (53%), Gaps = 27/350 (7%)
Query: 1325 DNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSH--PEEFLIFATRGSITYIS 1382
D CS +C+ + C C G + T K CK+ LIF R + I
Sbjct: 382 DPDACSQICVNYKGYFKCECYPGYEMDLLT-----KNCKAAGGKSPSLIFTNRYEVRRID 436
Query: 1383 LESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESK---TIIS 1439
L + +P+ +KN +A+D I++ DL I S M S+ K +I
Sbjct: 437 LVK-RNYSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLID 493
Query: 1440 QKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLIT-GLTEPRALALFPAKGY 1498
++L +P GL VDW+ +IYWTD+ +K I VA +DG R+ L + L+EPRA+A+ P +G+
Sbjct: 494 EQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGF 553
Query: 1499 LYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDL 1558
+YWSDWG+ IE+S L+G RQ +V ++ +PNG+T+D +RLYW D+ ++ + D
Sbjct: 554 MYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDF 613
Query: 1559 NGQHRVQLVPDA---KNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAM 1615
+G +R L+ +PFG+ F+D ++WTD ++I A++ G I+++ NL
Sbjct: 614 SGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPH 673
Query: 1616 EIKAVSADRQ-HGWNPCK---ESNGGCSHLCL----FRGH--EYICACPD 1655
+I +Q + C+ + NGGC +LCL H +Y CACPD
Sbjct: 674 DIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPD 723
Score = 175 bits (426), Expect = 1e-42
Identities = 111/338 (32%), Positives = 167/338 (49%), Gaps = 47/338 (13%)
Query: 762 MDIHSRSCEETPEKL--LLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQK 819
MD+ +++C+ K L++ R ++R L + + +IP+ +K+ VALD +
Sbjct: 407 MDLLTKNCKAAGGKSPSLIFTNRYEVRRIDLVKR----NYSRLIPM--LKNVVALDVEVA 460
Query: 820 SNSIFWTDVEKDTINRAYLNGS----HQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNR 875
+N I+W D+ I AY++ + Q ++D L P GLA DW+ IYWTD G
Sbjct: 461 TNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKT 520
Query: 876 IEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIF 935
I V+ DG R L ++ +PR I V+P G MYWSDWG IE++ ++G +R+ L+
Sbjct: 521 ISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVS 580
Query: 936 GQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN---LPHPFGLDLYGDE 992
+ WPNG+ LDL+ R+YW D + + G R LI + L HPFG+ ++ D+
Sbjct: 581 DNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDK 640
Query: 993 VFWTDWDTQSIQAANKDTGAKRRTLGCGKN--------------------------NGGC 1026
VFWTD + ++I +AN+ G + L N NGGC
Sbjct: 641 VFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGC 700
Query: 1027 SHLCLLKPGGRS------CACPIGIKLNKDGKTCADGP 1058
+LCL P S CACP + L D K C P
Sbjct: 701 EYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAP 738
Score = 140 bits (339), Expect = 4e-32
Identities = 66/183 (36%), Positives = 94/183 (51%), Gaps = 16/183 (8%)
Query: 247 AANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNA 306
AA+P P + C + F+C+N +C+P ++CD D+DC D +DED CP +C
Sbjct: 33 AADPLLGGQGPAK--ECEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKTCAD 88
Query: 307 GEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTC--ADRRCVLKTWL 364
+F C++G CI ERW+CD E +C DG DE + C ++ +C +CV +W
Sbjct: 89 SDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTK-QVCPAEKLSCGPTSHKCVPASWR 147
Query: 365 CDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE 424
CDG +DC G DE C C ++ C R+C+ VCDG DC G DE
Sbjct: 148 CDGEKDCEGGADEAGCATLCAPHEFQC---------GNRSCLAAVFVCDGDDDCGDGSDE 198
Query: 425 ERC 427
C
Sbjct: 199 RGC 201
Score = 101 bits (241), Expect = 3e-20
Identities = 77/281 (27%), Positives = 126/281 (44%), Gaps = 18/281 (6%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVP 1078
C NNGGCSH+C G C CP G +L D KTC D I+ ++
Sbjct: 340 CLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGD--IDECKDPDACSQICVNYKGY 396
Query: 1079 YLIDVV--LPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTA 1136
+ + + L S LI+ R+I R + + ++ N +
Sbjct: 397 FKCECYPGYEMDLLTKNCKAAGGKSPSLIFTNRYEVRRIDLVKRNYSRLIPMLKNVV--- 453
Query: 1137 DGIVIDSTGRKIYWTDGGRNSIEVAEL----DGRNRKVLVWTGLDSPRAIALHYEYGYMF 1192
+ ++ +IYW D I A + D + ++VL+ L SP +A+ + + +++
Sbjct: 454 -ALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
Query: 1193 WSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFD 1251
W+D G I A +DG RR + + P +A+D + G +YW+D IE S +
Sbjct: 513 WTDSGNKT-ISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 571
Query: 1252 GHDRRTVLS-NVPYPYGIV--IVGQHIYWTDWKTKALHRAD 1289
G DR+T++S N+ +P GI ++ Q +YW D K L D
Sbjct: 572 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSID 612
Score = 90.2 bits (214), Expect = 6e-17
Identities = 82/297 (27%), Positives = 128/297 (43%), Gaps = 21/297 (7%)
Query: 1320 NACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSIT 1379
N C +NGGCSH+C +G+ C CP G T +CK P+
Sbjct: 338 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD-PDACSQICVNYK-G 395
Query: 1380 YISLESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIIS 1439
Y E +++ L K K +IF + +R I++ + S+ I
Sbjct: 396 YFKCECYPGYEMDLLTKNCKAAGGK----SPSLIFTNRYE---VRRIDLVKRNYSRLI-- 446
Query: 1440 QKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSS----RKVLI-TGLTEPRALALFP 1494
L+ L V+ N IYW D ++ I A +D +S ++VLI L P LA+
Sbjct: 447 PMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDW 506
Query: 1495 AKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTD-ALKDRI 1553
++YW+D G + I + +DG +R+ + +L P + +D +YW+D + +I
Sbjct: 507 VHKHIYWTDSG-NKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKI 565
Query: 1554 DTSDLNGQHRVQLVPD-AKNPFGMT--QFKDYIYWTDWYKKSIIRADKRTGKNITLI 1607
+ S LNG R LV D + P G+T +YW D + D G TLI
Sbjct: 566 EKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLI 622
Score = 64.9 bits (151), Expect = 2e-09
Identities = 31/96 (32%), Positives = 50/96 (52%), Gaps = 11/96 (11%)
Query: 344 RNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC-EVSCEEDQYTCRPQEHLMSNAF 402
+ C D++ C + RC+ W CD DC + DE +C + +C + +TC N
Sbjct: 45 KECEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-------DNG- 96
Query: 403 RNCVNRKHVCDGMKDCPRGDDE-ERCPLKRKCSAEE 437
+C++ + CDG ++CP G DE E K+ C AE+
Sbjct: 97 -HCIHERWKCDGEEECPDGSDESEATCTKQVCPAEK 131
Score = 54.0 bits (124), Expect = 5e-06
Identities = 54/233 (23%), Positives = 102/233 (43%), Gaps = 20/233 (8%)
Query: 680 LTIDYTESKIYWADAKHHVIERA----AFDGRDRRKVTTKGL--PHPFALTLFDDAIYWT 733
L ++ ++IYW D + I A A D +++ + + L P A+ IYWT
Sbjct: 455 LDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWT 514
Query: 734 DWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESK 793
D K+IS + G L+ P R+ P + +Y D + K
Sbjct: 515 DSGNKTISVATVDGGRRRTLFSRNLSEP-----RAIAVDPLRGFMYW--SDWGDQAKIEK 567
Query: 794 KPIDSLD-MVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSN-- 850
++ +D + + I+ + D S ++W D + ++ +G ++ T++ S
Sbjct: 568 SGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDF 627
Query: 851 LIWPAGLAFDWITDKIYWTDGGTNRI-EVSKSDGSMRTLLAWDHIDKPRDIVV 902
L P G+A DK++WTD I ++ +G ++LA ++++ P DIV+
Sbjct: 628 LSHPFGIAV--FEDKVFWTDLENEAIFSANRLNGLEISILA-ENLNNPHDIVI 677
Score = 41.9 bits (94), Expect = 0.020
Identities = 28/88 (31%), Positives = 37/88 (42%), Gaps = 5/88 (5%)
Query: 110 EDDAGCITP-CLKINFSC-QISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTIC 167
E +A C C SC S C+P R C HE + C
Sbjct: 117 ESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQ--C 174
Query: 168 HSTNVCIALEWLCDGDNDCGDFSDEINC 195
+ + C+A ++CDGD+DCGD SDE C
Sbjct: 175 GNRS-CLAAVFVCDGDDDCGDGSDERGC 201
Score = 39.5 bits (88), Expect = 0.11
Identities = 14/23 (60%), Positives = 16/23 (69%)
Query: 173 CIALEWLCDGDNDCGDFSDEINC 195
C+ L W CDGD DC D SDE +C
Sbjct: 272 CVHLGWRCDGDRDCKDKSDEADC 294
Score = 37.9 bits (84), Expect = 0.33
Identities = 24/86 (27%), Positives = 28/86 (32%)
Query: 107 EGTEDDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTI 166
EG D+AGC T C F C + +C E R
Sbjct: 155 EGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCG 214
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDE 192
CI W+CD DC D SDE
Sbjct: 215 GDGGGACIPERWVCDRQFDCEDRSDE 240
Score = 35.9 bits (79), Expect = 1.3
Identities = 13/28 (46%), Positives = 16/28 (57%)
Query: 1627 GWNPCKESNGGCSHLCLFRGHEYICACP 1654
G N C +NGGCSH+C + C CP
Sbjct: 336 GLNECLHNNGGCSHICTDLKIGFECTCP 363
>D50678-1|BAA09328.1| 963|Homo sapiens apolipoprotein E receptor 2
precursor protein.
Length = 963
Score = 366 bits (901), Expect = e-100
Identities = 195/524 (37%), Positives = 282/524 (53%), Gaps = 37/524 (7%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND---GKCIPE 319
CA +F+C N C+ F CDGD+DCGD +DE C +C EF+C G CIPE
Sbjct: 167 CAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC--ADPACGPREFRCGGDGGGACIPE 224
Query: 320 RWRCDNERDCADGGDE---LNCKP-----NSIRNCS-LDEYTCADRRCVLKTWLCDGVRD 370
RW CD + DC D DE L +P ++ C+ + ++ C CV W CDG RD
Sbjct: 225 RWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATVSQFACRSGECVHLGWRCDGDRD 284
Query: 371 CTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC--P 428
C + DE +C + TCR E + CV C+ +DCP G DE C
Sbjct: 285 CKDKSDEADCPLG------TCRGDEFQCGDG--TCVLAIKHCNQEQDCPDGSDEAGCLQG 336
Query: 429 LKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQTCS 487
L C +C G C CP GF L + K +C DIDEC +DP CSQ C
Sbjct: 337 LNECLHNNGGCSHICTDLKIGFE-CTCPAGFQLLDQK-TCGDIDEC---KDPDACSQICV 391
Query: 488 NTVGSFRCGCMTGYILRPDERSCKPTG-ESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHN 546
N G F+C C GY + ++CK G +SP+L+F+NR +R++ L NY ++ L N
Sbjct: 392 NYKGYFKCECYPGYEMDLLTKNCKAAGGKSPSLIFTNRYEVRRIDLVKRNYSRLIPMLKN 451
Query: 547 AVALDYHYEKKLVFWSENNLRVIRVAQMNT----KNMSDVIRWGLETPAGVAVDWIHDLL 602
VALD ++W + + R I A M+ K +I L +P G+AVDW+H +
Sbjct: 452 VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 511
Query: 603 FWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMD 662
+WTDSG + + VAT+DG +R L + +L +PRAIAV P ++W+DWG KIE++ ++
Sbjct: 512 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 571
Query: 663 GDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKV--TTKGLPHP 720
G R+T++ D I WPNG+T+D ++YW D+K H + F G +R+ + +T L HP
Sbjct: 572 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 631
Query: 721 FALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDI 764
F + +F+D ++WTD ++I + N+ G+ I + LN P DI
Sbjct: 632 FGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDI 675
Score = 221 bits (541), Expect = 1e-56
Identities = 124/349 (35%), Positives = 192/349 (55%), Gaps = 25/349 (7%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC--ADGPINYLIFAHRVDIRVISLDVP 1078
K+ CS +C+ G C C G +++ K C A G LIF +R ++R I L V
Sbjct: 381 KDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAGGKSPSLIFTNRYEVRRIDL-VK 439
Query: 1079 YLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRA----TRLGTHVETVIGNGLH 1134
++P+ LKN + +DV+ +T IYW D RKI A E +I LH
Sbjct: 440 RNYSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH 497
Query: 1135 TADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWS 1194
+ +G+ +D + IYWTD G +I VA +DG R+ L L PRAIA+ G+M+WS
Sbjct: 498 SPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWS 557
Query: 1195 DWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHD 1254
DWG AKIE++ ++G +R+ +V + I+WPNG+ +D + RLYW D+K+ + S DF G +
Sbjct: 558 DWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGN 617
Query: 1255 RRTVLSN---VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDI-- 1309
R+T++S+ + +P+GI + ++WTD + +A+ A++ N + ++ +NL DI
Sbjct: 618 RKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVI 677
Query: 1310 -RAIQSERVLENACGTD---NGGCSHLCLRSPL------GYTCACPTGM 1348
++ R +AC NGGC +LCL +P YTCACP M
Sbjct: 678 FHELKQPRA-PDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTM 725
Score = 206 bits (503), Expect = 6e-52
Identities = 118/350 (33%), Positives = 186/350 (53%), Gaps = 27/350 (7%)
Query: 1325 DNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSH--PEEFLIFATRGSITYIS 1382
D CS +C+ + C C G + T K CK+ LIF R + I
Sbjct: 382 DPDACSQICVNYKGYFKCECYPGYEMDLLT-----KNCKAAGGKSPSLIFTNRYEVRRID 436
Query: 1383 LESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESK---TIIS 1439
L + +P+ +KN +A+D I++ DL I S M S+ K +I
Sbjct: 437 LVK-RNYSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLID 493
Query: 1440 QKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLIT-GLTEPRALALFPAKGY 1498
++L +P GL VDW+ +IYWTD+ +K I VA +DG R+ L + L+EPRA+A+ P +G+
Sbjct: 494 EQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGF 553
Query: 1499 LYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDL 1558
+YWSDWG+ IE+S L+G RQ +V ++ +PNG+T+D +RLYW D+ ++ + D
Sbjct: 554 MYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDF 613
Query: 1559 NGQHRVQLVPDA---KNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAM 1615
+G +R L+ +PFG+ F+D ++WTD ++I A++ G I+++ NL
Sbjct: 614 SGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPH 673
Query: 1616 EIKAVSADRQ-HGWNPCK---ESNGGCSHLCL----FRGH--EYICACPD 1655
+I +Q + C+ + NGGC +LCL H +Y CACPD
Sbjct: 674 DIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPD 723
Score = 175 bits (426), Expect = 1e-42
Identities = 111/338 (32%), Positives = 167/338 (49%), Gaps = 47/338 (13%)
Query: 762 MDIHSRSCEETPEKL--LLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQK 819
MD+ +++C+ K L++ R ++R L + + +IP+ +K+ VALD +
Sbjct: 407 MDLLTKNCKAAGGKSPSLIFTNRYEVRRIDLVKR----NYSRLIPM--LKNVVALDVEVA 460
Query: 820 SNSIFWTDVEKDTINRAYLNGS----HQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNR 875
+N I+W D+ I AY++ + Q ++D L P GLA DW+ IYWTD G
Sbjct: 461 TNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKT 520
Query: 876 IEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIF 935
I V+ DG R L ++ +PR I V+P G MYWSDWG IE++ ++G +R+ L+
Sbjct: 521 ISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVS 580
Query: 936 GQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN---LPHPFGLDLYGDE 992
+ WPNG+ LDL+ R+YW D + + G R LI + L HPFG+ ++ D+
Sbjct: 581 DNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDK 640
Query: 993 VFWTDWDTQSIQAANKDTGAKRRTLGCGKN--------------------------NGGC 1026
VFWTD + ++I +AN+ G + L N NGGC
Sbjct: 641 VFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGC 700
Query: 1027 SHLCLLKPGGRS------CACPIGIKLNKDGKTCADGP 1058
+LCL P S CACP + L D K C P
Sbjct: 701 EYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAP 738
Score = 140 bits (339), Expect = 4e-32
Identities = 66/183 (36%), Positives = 94/183 (51%), Gaps = 16/183 (8%)
Query: 247 AANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNA 306
AA+P P + C + F+C+N +C+P ++CD D+DC D +DED CP +C
Sbjct: 33 AADPLLGGQGPAK--ECEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKTCAD 88
Query: 307 GEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTC--ADRRCVLKTWL 364
+F C++G CI ERW+CD E +C DG DE + C ++ +C +CV +W
Sbjct: 89 SDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTK-QVCPAEKLSCGPTSHKCVPASWR 147
Query: 365 CDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE 424
CDG +DC G DE C C ++ C R+C+ VCDG DC G DE
Sbjct: 148 CDGEKDCEGGADEAGCATLCAPHEFQC---------GNRSCLAAVFVCDGDDDCGDGSDE 198
Query: 425 ERC 427
C
Sbjct: 199 RGC 201
Score = 101 bits (241), Expect = 3e-20
Identities = 77/281 (27%), Positives = 126/281 (44%), Gaps = 18/281 (6%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVP 1078
C NNGGCSH+C G C CP G +L D KTC D I+ ++
Sbjct: 340 CLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGD--IDECKDPDACSQICVNYKGY 396
Query: 1079 YLIDVV--LPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTA 1136
+ + + L S LI+ R+I R + + ++ N +
Sbjct: 397 FKCECYPGYEMDLLTKNCKAAGGKSPSLIFTNRYEVRRIDLVKRNYSRLIPMLKNVV--- 453
Query: 1137 DGIVIDSTGRKIYWTDGGRNSIEVAEL----DGRNRKVLVWTGLDSPRAIALHYEYGYMF 1192
+ ++ +IYW D I A + D + ++VL+ L SP +A+ + + +++
Sbjct: 454 -ALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
Query: 1193 WSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFD 1251
W+D G I A +DG RR + + P +A+D + G +YW+D IE S +
Sbjct: 513 WTDSGNKT-ISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 571
Query: 1252 GHDRRTVLS-NVPYPYGIV--IVGQHIYWTDWKTKALHRAD 1289
G DR+T++S N+ +P GI ++ Q +YW D K L D
Sbjct: 572 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSID 612
Score = 90.2 bits (214), Expect = 6e-17
Identities = 82/297 (27%), Positives = 128/297 (43%), Gaps = 21/297 (7%)
Query: 1320 NACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSIT 1379
N C +NGGCSH+C +G+ C CP G T +CK P+
Sbjct: 338 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD-PDACSQICVNYK-G 395
Query: 1380 YISLESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIIS 1439
Y E +++ L K K +IF + +R I++ + S+ I
Sbjct: 396 YFKCECYPGYEMDLLTKNCKAAGGK----SPSLIFTNRYE---VRRIDLVKRNYSRLI-- 446
Query: 1440 QKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSS----RKVLI-TGLTEPRALALFP 1494
L+ L V+ N IYW D ++ I A +D +S ++VLI L P LA+
Sbjct: 447 PMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDW 506
Query: 1495 AKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTD-ALKDRI 1553
++YW+D G + I + +DG +R+ + +L P + +D +YW+D + +I
Sbjct: 507 VHKHIYWTDSG-NKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKI 565
Query: 1554 DTSDLNGQHRVQLVPD-AKNPFGMT--QFKDYIYWTDWYKKSIIRADKRTGKNITLI 1607
+ S LNG R LV D + P G+T +YW D + D G TLI
Sbjct: 566 EKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLI 622
Score = 64.9 bits (151), Expect = 2e-09
Identities = 31/96 (32%), Positives = 50/96 (52%), Gaps = 11/96 (11%)
Query: 344 RNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC-EVSCEEDQYTCRPQEHLMSNAF 402
+ C D++ C + RC+ W CD DC + DE +C + +C + +TC N
Sbjct: 45 KECEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-------DNG- 96
Query: 403 RNCVNRKHVCDGMKDCPRGDDE-ERCPLKRKCSAEE 437
+C++ + CDG ++CP G DE E K+ C AE+
Sbjct: 97 -HCIHERWKCDGEEECPDGSDESEATCTKQVCPAEK 131
Score = 54.0 bits (124), Expect = 5e-06
Identities = 54/233 (23%), Positives = 102/233 (43%), Gaps = 20/233 (8%)
Query: 680 LTIDYTESKIYWADAKHHVIERA----AFDGRDRRKVTTKGL--PHPFALTLFDDAIYWT 733
L ++ ++IYW D + I A A D +++ + + L P A+ IYWT
Sbjct: 455 LDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWT 514
Query: 734 DWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESK 793
D K+IS + G L+ P R+ P + +Y D + K
Sbjct: 515 DSGNKTISVATVDGGRRRTLFSRNLSEP-----RAIAVDPLRGFMYW--SDWGDQAKIEK 567
Query: 794 KPIDSLD-MVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSN-- 850
++ +D + + I+ + D S ++W D + ++ +G ++ T++ S
Sbjct: 568 SGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDF 627
Query: 851 LIWPAGLAFDWITDKIYWTDGGTNRI-EVSKSDGSMRTLLAWDHIDKPRDIVV 902
L P G+A DK++WTD I ++ +G ++LA ++++ P DIV+
Sbjct: 628 LSHPFGIAV--FEDKVFWTDLENEAIFSANRLNGLEISILA-ENLNNPHDIVI 677
Score = 41.9 bits (94), Expect = 0.020
Identities = 28/88 (31%), Positives = 37/88 (42%), Gaps = 5/88 (5%)
Query: 110 EDDAGCITP-CLKINFSC-QISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTIC 167
E +A C C SC S C+P R C HE + C
Sbjct: 117 ESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQ--C 174
Query: 168 HSTNVCIALEWLCDGDNDCGDFSDEINC 195
+ + C+A ++CDGD+DCGD SDE C
Sbjct: 175 GNRS-CLAAVFVCDGDDDCGDGSDERGC 201
Score = 39.5 bits (88), Expect = 0.11
Identities = 14/23 (60%), Positives = 16/23 (69%)
Query: 173 CIALEWLCDGDNDCGDFSDEINC 195
C+ L W CDGD DC D SDE +C
Sbjct: 272 CVHLGWRCDGDRDCKDKSDEADC 294
Score = 37.9 bits (84), Expect = 0.33
Identities = 24/86 (27%), Positives = 28/86 (32%)
Query: 107 EGTEDDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTI 166
EG D+AGC T C F C + +C E R
Sbjct: 155 EGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCG 214
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDE 192
CI W+CD DC D SDE
Sbjct: 215 GDGGGACIPERWVCDRQFDCEDRSDE 240
Score = 35.9 bits (79), Expect = 1.3
Identities = 13/28 (46%), Positives = 16/28 (57%)
Query: 1627 GWNPCKESNGGCSHLCLFRGHEYICACP 1654
G N C +NGGCSH+C + C CP
Sbjct: 336 GLNECLHNNGGCSHICTDLKIGFECTCP 363
>BC051836-1|AAH51836.2| 904|Homo sapiens low density lipoprotein
receptor-related protein 8, apolipoprotein e receptor
protein.
Length = 904
Score = 365 bits (897), Expect = 1e-99
Identities = 195/524 (37%), Positives = 281/524 (53%), Gaps = 37/524 (7%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND---GKCIPE 319
CA +F+C N C+ F CDGD+DCGD +DE C +C EF+C G CIPE
Sbjct: 167 CAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC--ADPACGPREFRCGGDGGGACIPE 224
Query: 320 RWRCDNERDCADGGDE---LNCKP-----NSIRNCSL-DEYTCADRRCVLKTWLCDGVRD 370
RW CD + DC D DE L +P ++ C+ ++ C CV W CDG RD
Sbjct: 225 RWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRD 284
Query: 371 CTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC--P 428
C + DE +C + TCR E + CV C+ +DCP G DE C
Sbjct: 285 CKDKSDEADCPLG------TCRGDEFQCGDG--TCVLAIKHCNQEQDCPDGSDEAGCLQG 336
Query: 429 LKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQTCS 487
L C +C G C CP GF L + K +C DIDEC +DP CSQ C
Sbjct: 337 LNECLHNNGGCSHICTDLKIGFE-CTCPAGFQLLDQK-TCGDIDEC---KDPDACSQICV 391
Query: 488 NTVGSFRCGCMTGYILRPDERSCKPT-GESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHN 546
N G F+C C GY + ++CK G+SP+L+F+NR +R++ L NY ++ L N
Sbjct: 392 NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKN 451
Query: 547 AVALDYHYEKKLVFWSENNLRVIRVAQMNT----KNMSDVIRWGLETPAGVAVDWIHDLL 602
VALD ++W + + R I A M+ K +I L +P G+AVDW+H +
Sbjct: 452 VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 511
Query: 603 FWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMD 662
+WTDSG + + VAT+DG +R L + +L +PRAIAV P ++W+DWG KIE++ ++
Sbjct: 512 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 571
Query: 663 GDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKV--TTKGLPHP 720
G R+T++ D I WPNG+T+D ++YW D+K H + F G +R+ + +T L HP
Sbjct: 572 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 631
Query: 721 FALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDI 764
F + +F+D ++WTD ++I + N+ G+ I + LN P DI
Sbjct: 632 FGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDI 675
Score = 220 bits (538), Expect = 3e-56
Identities = 124/349 (35%), Positives = 192/349 (55%), Gaps = 25/349 (7%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC--ADGPINYLIFAHRVDIRVISLDVP 1078
K+ CS +C+ G C C G +++ K C A G LIF +R ++R I L V
Sbjct: 381 KDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDL-VK 439
Query: 1079 YLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRA----TRLGTHVETVIGNGLH 1134
++P+ LKN + +DV+ +T IYW D RKI A E +I LH
Sbjct: 440 RNYSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH 497
Query: 1135 TADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWS 1194
+ +G+ +D + IYWTD G +I VA +DG R+ L L PRAIA+ G+M+WS
Sbjct: 498 SPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWS 557
Query: 1195 DWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHD 1254
DWG AKIE++ ++G +R+ +V + I+WPNG+ +D + RLYW D+K+ + S DF G +
Sbjct: 558 DWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGN 617
Query: 1255 RRTVLSN---VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDI-- 1309
R+T++S+ + +P+GI + ++WTD + +A+ A++ N + ++ +NL DI
Sbjct: 618 RKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVI 677
Query: 1310 -RAIQSERVLENACGTD---NGGCSHLCLRSPL------GYTCACPTGM 1348
++ R +AC NGGC +LCL +P YTCACP M
Sbjct: 678 FHELKQPRA-PDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTM 725
Score = 206 bits (504), Expect = 4e-52
Identities = 118/348 (33%), Positives = 186/348 (53%), Gaps = 23/348 (6%)
Query: 1325 DNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLE 1384
D CS +C+ + C C G + T + KS P LIF R + I L
Sbjct: 382 DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKS-PS--LIFTNRHEVRRIDLV 438
Query: 1385 SPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESK---TIISQK 1441
+ +P+ +KN +A+D I++ DL I S M S+ K +I ++
Sbjct: 439 K-RNYSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQ 495
Query: 1442 LETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLIT-GLTEPRALALFPAKGYLY 1500
L +P GL VDW+ +IYWTD+ +K I VA +DG R+ L + L+EPRA+A+ P +G++Y
Sbjct: 496 LHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMY 555
Query: 1501 WSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNG 1560
WSDWG+ IE+S L+G RQ +V ++ +PNG+T+D +RLYW D+ ++ + D +G
Sbjct: 556 WSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSG 615
Query: 1561 QHRVQLVPDA---KNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEI 1617
+R L+ +PFG+ F+D ++WTD ++I A++ G I+++ NL +I
Sbjct: 616 GNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDI 675
Query: 1618 KAVSADRQ-HGWNPCK---ESNGGCSHLCL----FRGH--EYICACPD 1655
+Q + C+ + NGGC +LCL H +Y CACPD
Sbjct: 676 VIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPD 723
Score = 176 bits (428), Expect = 7e-43
Identities = 111/338 (32%), Positives = 167/338 (49%), Gaps = 47/338 (13%)
Query: 762 MDIHSRSCEETPEKL--LLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQK 819
MD+ +++C+ K L++ R ++R L + + +IP+ +K+ VALD +
Sbjct: 407 MDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKR----NYSRLIPM--LKNVVALDVEVA 460
Query: 820 SNSIFWTDVEKDTINRAYLNGS----HQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNR 875
+N I+W D+ I AY++ + Q ++D L P GLA DW+ IYWTD G
Sbjct: 461 TNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKT 520
Query: 876 IEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIF 935
I V+ DG R L ++ +PR I V+P G MYWSDWG IE++ ++G +R+ L+
Sbjct: 521 ISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVS 580
Query: 936 GQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN---LPHPFGLDLYGDE 992
+ WPNG+ LDL+ R+YW D + + G R LI + L HPFG+ ++ D+
Sbjct: 581 DNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDK 640
Query: 993 VFWTDWDTQSIQAANKDTGAKRRTLGCGKN--------------------------NGGC 1026
VFWTD + ++I +AN+ G + L N NGGC
Sbjct: 641 VFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGC 700
Query: 1027 SHLCLLKPGGRS------CACPIGIKLNKDGKTCADGP 1058
+LCL P S CACP + L D K C P
Sbjct: 701 EYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAP 738
Score = 140 bits (339), Expect = 4e-32
Identities = 66/183 (36%), Positives = 94/183 (51%), Gaps = 16/183 (8%)
Query: 247 AANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNA 306
AA+P P + C + F+C+N +C+P ++CD D+DC D +DED CP +C
Sbjct: 33 AADPLLGGQGPAK--ECEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKTCAD 88
Query: 307 GEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTC--ADRRCVLKTWL 364
+F C++G CI ERW+CD E +C DG DE + C ++ +C +CV +W
Sbjct: 89 SDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTK-QVCPAEKLSCGPTSHKCVPASWR 147
Query: 365 CDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE 424
CDG +DC G DE C C ++ C R+C+ VCDG DC G DE
Sbjct: 148 CDGEKDCEGGADEAGCATLCAPHEFQC---------GNRSCLAAVFVCDGDDDCGDGSDE 198
Query: 425 ERC 427
C
Sbjct: 199 RGC 201
Score = 102 bits (245), Expect = 1e-20
Identities = 77/281 (27%), Positives = 127/281 (45%), Gaps = 18/281 (6%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVP 1078
C NNGGCSH+C G C CP G +L D KTC D I+ ++
Sbjct: 340 CLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGD--IDECKDPDACSQICVNYKGY 396
Query: 1079 YLIDVV--LPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTA 1136
+ + + L S LI+ T + +++R + + +I L
Sbjct: 397 FKCECYPGYEMDLLTKNCKAAAGKSPSLIF---TNRHEVRRIDLVKRNYSRLIPM-LKNV 452
Query: 1137 DGIVIDSTGRKIYWTDGGRNSIEVAEL----DGRNRKVLVWTGLDSPRAIALHYEYGYMF 1192
+ ++ +IYW D I A + D + ++VL+ L SP +A+ + + +++
Sbjct: 453 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
Query: 1193 WSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFD 1251
W+D G I A +DG RR + + P +A+D + G +YW+D IE S +
Sbjct: 513 WTDSGNKT-ISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 571
Query: 1252 GHDRRTVLS-NVPYPYGIV--IVGQHIYWTDWKTKALHRAD 1289
G DR+T++S N+ +P GI ++ Q +YW D K L D
Sbjct: 572 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSID 612
Score = 91.5 bits (217), Expect = 3e-17
Identities = 82/297 (27%), Positives = 129/297 (43%), Gaps = 21/297 (7%)
Query: 1320 NACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSIT 1379
N C +NGGCSH+C +G+ C CP G T +CK P+
Sbjct: 338 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD-PDACSQICVNYK-G 395
Query: 1380 YISLESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIIS 1439
Y E +++ L K K +IF + + +R I++ + S+ I
Sbjct: 396 YFKCECYPGYEMDLLTKNCKAAAGK----SPSLIF---TNRHEVRRIDLVKRNYSRLI-- 446
Query: 1440 QKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSS----RKVLI-TGLTEPRALALFP 1494
L+ L V+ N IYW D ++ I A +D +S ++VLI L P LA+
Sbjct: 447 PMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDW 506
Query: 1495 AKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTD-ALKDRI 1553
++YW+D G + I + +DG +R+ + +L P + +D +YW+D + +I
Sbjct: 507 VHKHIYWTDSG-NKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKI 565
Query: 1554 DTSDLNGQHRVQLVPD-AKNPFGMT--QFKDYIYWTDWYKKSIIRADKRTGKNITLI 1607
+ S LNG R LV D + P G+T +YW D + D G TLI
Sbjct: 566 EKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLI 622
Score = 64.9 bits (151), Expect = 2e-09
Identities = 31/96 (32%), Positives = 50/96 (52%), Gaps = 11/96 (11%)
Query: 344 RNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC-EVSCEEDQYTCRPQEHLMSNAF 402
+ C D++ C + RC+ W CD DC + DE +C + +C + +TC N
Sbjct: 45 KECEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-------DNG- 96
Query: 403 RNCVNRKHVCDGMKDCPRGDDE-ERCPLKRKCSAEE 437
+C++ + CDG ++CP G DE E K+ C AE+
Sbjct: 97 -HCIHERWKCDGEEECPDGSDESEATCTKQVCPAEK 131
Score = 54.0 bits (124), Expect = 5e-06
Identities = 54/233 (23%), Positives = 102/233 (43%), Gaps = 20/233 (8%)
Query: 680 LTIDYTESKIYWADAKHHVIERA----AFDGRDRRKVTTKGL--PHPFALTLFDDAIYWT 733
L ++ ++IYW D + I A A D +++ + + L P A+ IYWT
Sbjct: 455 LDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWT 514
Query: 734 DWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESK 793
D K+IS + G L+ P R+ P + +Y D + K
Sbjct: 515 DSGNKTISVATVDGGRRRTLFSRNLSEP-----RAIAVDPLRGFMYW--SDWGDQAKIEK 567
Query: 794 KPIDSLD-MVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSN-- 850
++ +D + + I+ + D S ++W D + ++ +G ++ T++ S
Sbjct: 568 SGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDF 627
Query: 851 LIWPAGLAFDWITDKIYWTDGGTNRI-EVSKSDGSMRTLLAWDHIDKPRDIVV 902
L P G+A DK++WTD I ++ +G ++LA ++++ P DIV+
Sbjct: 628 LSHPFGIAV--FEDKVFWTDLENEAIFSANRLNGLEISILA-ENLNNPHDIVI 677
Score = 41.9 bits (94), Expect = 0.020
Identities = 28/88 (31%), Positives = 37/88 (42%), Gaps = 5/88 (5%)
Query: 110 EDDAGCITP-CLKINFSC-QISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTIC 167
E +A C C SC S C+P R C HE + C
Sbjct: 117 ESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQ--C 174
Query: 168 HSTNVCIALEWLCDGDNDCGDFSDEINC 195
+ + C+A ++CDGD+DCGD SDE C
Sbjct: 175 GNRS-CLAAVFVCDGDDDCGDGSDERGC 201
Score = 39.5 bits (88), Expect = 0.11
Identities = 14/23 (60%), Positives = 16/23 (69%)
Query: 173 CIALEWLCDGDNDCGDFSDEINC 195
C+ L W CDGD DC D SDE +C
Sbjct: 272 CVHLGWRCDGDRDCKDKSDEADC 294
Score = 37.9 bits (84), Expect = 0.33
Identities = 24/86 (27%), Positives = 28/86 (32%)
Query: 107 EGTEDDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTI 166
EG D+AGC T C F C + +C E R
Sbjct: 155 EGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCG 214
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDE 192
CI W+CD DC D SDE
Sbjct: 215 GDGGGACIPERWVCDRQFDCEDRSDE 240
Score = 35.9 bits (79), Expect = 1.3
Identities = 13/28 (46%), Positives = 16/28 (57%)
Query: 1627 GWNPCKESNGGCSHLCLFRGHEYICACP 1654
G N C +NGGCSH+C + C CP
Sbjct: 336 GLNECLHNNGGCSHICTDLKIGFECTCP 363
>AL606760-4|CAI18908.1| 963|Homo sapiens low density lipoprotein
receptor-related protein 8, apolipoprotein e receptor
protein.
Length = 963
Score = 365 bits (897), Expect = 1e-99
Identities = 195/524 (37%), Positives = 281/524 (53%), Gaps = 37/524 (7%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND---GKCIPE 319
CA +F+C N C+ F CDGD+DCGD +DE C +C EF+C G CIPE
Sbjct: 167 CAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC--ADPACGPREFRCGGDGGGACIPE 224
Query: 320 RWRCDNERDCADGGDE---LNCKP-----NSIRNCSL-DEYTCADRRCVLKTWLCDGVRD 370
RW CD + DC D DE L +P ++ C+ ++ C CV W CDG RD
Sbjct: 225 RWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRD 284
Query: 371 CTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC--P 428
C + DE +C + TCR E + CV C+ +DCP G DE C
Sbjct: 285 CKDKSDEADCPLG------TCRGDEFQCGDG--TCVLAIKHCNQEQDCPDGSDEAGCLQG 336
Query: 429 LKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQTCS 487
L C +C G C CP GF L + K +C DIDEC +DP CSQ C
Sbjct: 337 LNECLHNNGGCSHICTDLKIGFE-CTCPAGFQLLDQK-TCGDIDEC---KDPDACSQICV 391
Query: 488 NTVGSFRCGCMTGYILRPDERSCKPT-GESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHN 546
N G F+C C GY + ++CK G+SP+L+F+NR +R++ L NY ++ L N
Sbjct: 392 NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKN 451
Query: 547 AVALDYHYEKKLVFWSENNLRVIRVAQMNT----KNMSDVIRWGLETPAGVAVDWIHDLL 602
VALD ++W + + R I A M+ K +I L +P G+AVDW+H +
Sbjct: 452 VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 511
Query: 603 FWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMD 662
+WTDSG + + VAT+DG +R L + +L +PRAIAV P ++W+DWG KIE++ ++
Sbjct: 512 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 571
Query: 663 GDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKV--TTKGLPHP 720
G R+T++ D I WPNG+T+D ++YW D+K H + F G +R+ + +T L HP
Sbjct: 572 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 631
Query: 721 FALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDI 764
F + +F+D ++WTD ++I + N+ G+ I + LN P DI
Sbjct: 632 FGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDI 675
Score = 220 bits (538), Expect = 3e-56
Identities = 124/349 (35%), Positives = 192/349 (55%), Gaps = 25/349 (7%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC--ADGPINYLIFAHRVDIRVISLDVP 1078
K+ CS +C+ G C C G +++ K C A G LIF +R ++R I L V
Sbjct: 381 KDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDL-VK 439
Query: 1079 YLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRA----TRLGTHVETVIGNGLH 1134
++P+ LKN + +DV+ +T IYW D RKI A E +I LH
Sbjct: 440 RNYSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH 497
Query: 1135 TADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWS 1194
+ +G+ +D + IYWTD G +I VA +DG R+ L L PRAIA+ G+M+WS
Sbjct: 498 SPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWS 557
Query: 1195 DWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHD 1254
DWG AKIE++ ++G +R+ +V + I+WPNG+ +D + RLYW D+K+ + S DF G +
Sbjct: 558 DWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGN 617
Query: 1255 RRTVLSN---VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDI-- 1309
R+T++S+ + +P+GI + ++WTD + +A+ A++ N + ++ +NL DI
Sbjct: 618 RKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVI 677
Query: 1310 -RAIQSERVLENACGTD---NGGCSHLCLRSPL------GYTCACPTGM 1348
++ R +AC NGGC +LCL +P YTCACP M
Sbjct: 678 FHELKQPRA-PDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTM 725
Score = 206 bits (504), Expect = 4e-52
Identities = 118/348 (33%), Positives = 186/348 (53%), Gaps = 23/348 (6%)
Query: 1325 DNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLE 1384
D CS +C+ + C C G + T + KS P LIF R + I L
Sbjct: 382 DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKS-PS--LIFTNRHEVRRIDLV 438
Query: 1385 SPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESK---TIISQK 1441
+ +P+ +KN +A+D I++ DL I S M S+ K +I ++
Sbjct: 439 K-RNYSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQ 495
Query: 1442 LETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLIT-GLTEPRALALFPAKGYLY 1500
L +P GL VDW+ +IYWTD+ +K I VA +DG R+ L + L+EPRA+A+ P +G++Y
Sbjct: 496 LHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMY 555
Query: 1501 WSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNG 1560
WSDWG+ IE+S L+G RQ +V ++ +PNG+T+D +RLYW D+ ++ + D +G
Sbjct: 556 WSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSG 615
Query: 1561 QHRVQLVPDA---KNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEI 1617
+R L+ +PFG+ F+D ++WTD ++I A++ G I+++ NL +I
Sbjct: 616 GNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDI 675
Query: 1618 KAVSADRQ-HGWNPCK---ESNGGCSHLCL----FRGH--EYICACPD 1655
+Q + C+ + NGGC +LCL H +Y CACPD
Sbjct: 676 VIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPD 723
Score = 176 bits (428), Expect = 7e-43
Identities = 111/338 (32%), Positives = 167/338 (49%), Gaps = 47/338 (13%)
Query: 762 MDIHSRSCEETPEKL--LLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQK 819
MD+ +++C+ K L++ R ++R L + + +IP+ +K+ VALD +
Sbjct: 407 MDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKR----NYSRLIPM--LKNVVALDVEVA 460
Query: 820 SNSIFWTDVEKDTINRAYLNGS----HQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNR 875
+N I+W D+ I AY++ + Q ++D L P GLA DW+ IYWTD G
Sbjct: 461 TNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKT 520
Query: 876 IEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIF 935
I V+ DG R L ++ +PR I V+P G MYWSDWG IE++ ++G +R+ L+
Sbjct: 521 ISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVS 580
Query: 936 GQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN---LPHPFGLDLYGDE 992
+ WPNG+ LDL+ R+YW D + + G R LI + L HPFG+ ++ D+
Sbjct: 581 DNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDK 640
Query: 993 VFWTDWDTQSIQAANKDTGAKRRTLGCGKN--------------------------NGGC 1026
VFWTD + ++I +AN+ G + L N NGGC
Sbjct: 641 VFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGC 700
Query: 1027 SHLCLLKPGGRS------CACPIGIKLNKDGKTCADGP 1058
+LCL P S CACP + L D K C P
Sbjct: 701 EYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAP 738
Score = 140 bits (338), Expect = 5e-32
Identities = 62/167 (37%), Positives = 88/167 (52%), Gaps = 14/167 (8%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C + F+C+N +C+P ++CD D+DC D +DED CP +C +F C++G CI ERW+
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKTCADSDFTCDNGHCIHERWK 104
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTC--ADRRCVLKTWLCDGVRDCTNGEDEMNC 380
CD E +C DG DE + C ++ +C +CV +W CDG +DC G DE C
Sbjct: 105 CDGEEECPDGSDESEATCTK-QVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
Query: 381 EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC 427
C ++ C R+C+ VCDG DC G DE C
Sbjct: 164 ATLCAPHEFQC---------GNRSCLAAVFVCDGDDDCGDGSDERGC 201
Score = 102 bits (245), Expect = 1e-20
Identities = 77/281 (27%), Positives = 127/281 (45%), Gaps = 18/281 (6%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVP 1078
C NNGGCSH+C G C CP G +L D KTC D I+ ++
Sbjct: 340 CLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGD--IDECKDPDACSQICVNYKGY 396
Query: 1079 YLIDVV--LPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTA 1136
+ + + L S LI+ T + +++R + + +I L
Sbjct: 397 FKCECYPGYEMDLLTKNCKAAAGKSPSLIF---TNRHEVRRIDLVKRNYSRLIPM-LKNV 452
Query: 1137 DGIVIDSTGRKIYWTDGGRNSIEVAEL----DGRNRKVLVWTGLDSPRAIALHYEYGYMF 1192
+ ++ +IYW D I A + D + ++VL+ L SP +A+ + + +++
Sbjct: 453 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
Query: 1193 WSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFD 1251
W+D G I A +DG RR + + P +A+D + G +YW+D IE S +
Sbjct: 513 WTDSGNKT-ISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 571
Query: 1252 GHDRRTVLS-NVPYPYGIV--IVGQHIYWTDWKTKALHRAD 1289
G DR+T++S N+ +P GI ++ Q +YW D K L D
Sbjct: 572 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSID 612
Score = 91.5 bits (217), Expect = 3e-17
Identities = 82/297 (27%), Positives = 129/297 (43%), Gaps = 21/297 (7%)
Query: 1320 NACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSIT 1379
N C +NGGCSH+C +G+ C CP G T +CK P+
Sbjct: 338 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD-PDACSQICVNYK-G 395
Query: 1380 YISLESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIIS 1439
Y E +++ L K K +IF + + +R I++ + S+ I
Sbjct: 396 YFKCECYPGYEMDLLTKNCKAAAGK----SPSLIF---TNRHEVRRIDLVKRNYSRLI-- 446
Query: 1440 QKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSS----RKVLI-TGLTEPRALALFP 1494
L+ L V+ N IYW D ++ I A +D +S ++VLI L P LA+
Sbjct: 447 PMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDW 506
Query: 1495 AKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTD-ALKDRI 1553
++YW+D G + I + +DG +R+ + +L P + +D +YW+D + +I
Sbjct: 507 VHKHIYWTDSG-NKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKI 565
Query: 1554 DTSDLNGQHRVQLVPD-AKNPFGMT--QFKDYIYWTDWYKKSIIRADKRTGKNITLI 1607
+ S LNG R LV D + P G+T +YW D + D G TLI
Sbjct: 566 EKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLI 622
Score = 65.3 bits (152), Expect = 2e-09
Identities = 31/96 (32%), Positives = 51/96 (53%), Gaps = 11/96 (11%)
Query: 344 RNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC-EVSCEEDQYTCRPQEHLMSNAF 402
++C D++ C + RC+ W CD DC + DE +C + +C + +TC N
Sbjct: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-------DNG- 96
Query: 403 RNCVNRKHVCDGMKDCPRGDDE-ERCPLKRKCSAEE 437
+C++ + CDG ++CP G DE E K+ C AE+
Sbjct: 97 -HCIHERWKCDGEEECPDGSDESEATCTKQVCPAEK 131
Score = 54.0 bits (124), Expect = 5e-06
Identities = 54/233 (23%), Positives = 102/233 (43%), Gaps = 20/233 (8%)
Query: 680 LTIDYTESKIYWADAKHHVIERA----AFDGRDRRKVTTKGL--PHPFALTLFDDAIYWT 733
L ++ ++IYW D + I A A D +++ + + L P A+ IYWT
Sbjct: 455 LDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWT 514
Query: 734 DWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESK 793
D K+IS + G L+ P R+ P + +Y D + K
Sbjct: 515 DSGNKTISVATVDGGRRRTLFSRNLSEP-----RAIAVDPLRGFMYW--SDWGDQAKIEK 567
Query: 794 KPIDSLD-MVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSN-- 850
++ +D + + I+ + D S ++W D + ++ +G ++ T++ S
Sbjct: 568 SGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDF 627
Query: 851 LIWPAGLAFDWITDKIYWTDGGTNRI-EVSKSDGSMRTLLAWDHIDKPRDIVV 902
L P G+A DK++WTD I ++ +G ++LA ++++ P DIV+
Sbjct: 628 LSHPFGIAV--FEDKVFWTDLENEAIFSANRLNGLEISILA-ENLNNPHDIVI 677
Score = 41.9 bits (94), Expect = 0.020
Identities = 28/88 (31%), Positives = 37/88 (42%), Gaps = 5/88 (5%)
Query: 110 EDDAGCITP-CLKINFSC-QISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTIC 167
E +A C C SC S C+P R C HE + C
Sbjct: 117 ESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQ--C 174
Query: 168 HSTNVCIALEWLCDGDNDCGDFSDEINC 195
+ + C+A ++CDGD+DCGD SDE C
Sbjct: 175 GNRS-CLAAVFVCDGDDDCGDGSDERGC 201
Score = 39.5 bits (88), Expect = 0.11
Identities = 14/23 (60%), Positives = 16/23 (69%)
Query: 173 CIALEWLCDGDNDCGDFSDEINC 195
C+ L W CDGD DC D SDE +C
Sbjct: 272 CVHLGWRCDGDRDCKDKSDEADC 294
Score = 37.9 bits (84), Expect = 0.33
Identities = 24/86 (27%), Positives = 28/86 (32%)
Query: 107 EGTEDDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTI 166
EG D+AGC T C F C + +C E R
Sbjct: 155 EGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCG 214
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDE 192
CI W+CD DC D SDE
Sbjct: 215 GDGGGACIPERWVCDRQFDCEDRSDE 240
Score = 35.9 bits (79), Expect = 1.3
Identities = 13/28 (46%), Positives = 16/28 (57%)
Query: 1627 GWNPCKESNGGCSHLCLFRGHEYICACP 1654
G N C +NGGCSH+C + C CP
Sbjct: 336 GLNECLHNNGGCSHICTDLKIGFECTCP 363
>AL606760-2|CAI18910.1| 904|Homo sapiens low density lipoprotein
receptor-related protein 8, apolipoprotein e receptor
protein.
Length = 904
Score = 365 bits (897), Expect = 1e-99
Identities = 195/524 (37%), Positives = 281/524 (53%), Gaps = 37/524 (7%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND---GKCIPE 319
CA +F+C N C+ F CDGD+DCGD +DE C +C EF+C G CIPE
Sbjct: 167 CAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC--ADPACGPREFRCGGDGGGACIPE 224
Query: 320 RWRCDNERDCADGGDE---LNCKP-----NSIRNCSL-DEYTCADRRCVLKTWLCDGVRD 370
RW CD + DC D DE L +P ++ C+ ++ C CV W CDG RD
Sbjct: 225 RWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRD 284
Query: 371 CTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC--P 428
C + DE +C + TCR E + CV C+ +DCP G DE C
Sbjct: 285 CKDKSDEADCPLG------TCRGDEFQCGDG--TCVLAIKHCNQEQDCPDGSDEAGCLQG 336
Query: 429 LKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQTCS 487
L C +C G C CP GF L + K +C DIDEC +DP CSQ C
Sbjct: 337 LNECLHNNGGCSHICTDLKIGFE-CTCPAGFQLLDQK-TCGDIDEC---KDPDACSQICV 391
Query: 488 NTVGSFRCGCMTGYILRPDERSCKPT-GESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHN 546
N G F+C C GY + ++CK G+SP+L+F+NR +R++ L NY ++ L N
Sbjct: 392 NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKN 451
Query: 547 AVALDYHYEKKLVFWSENNLRVIRVAQMNT----KNMSDVIRWGLETPAGVAVDWIHDLL 602
VALD ++W + + R I A M+ K +I L +P G+AVDW+H +
Sbjct: 452 VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 511
Query: 603 FWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMD 662
+WTDSG + + VAT+DG +R L + +L +PRAIAV P ++W+DWG KIE++ ++
Sbjct: 512 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 571
Query: 663 GDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKV--TTKGLPHP 720
G R+T++ D I WPNG+T+D ++YW D+K H + F G +R+ + +T L HP
Sbjct: 572 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 631
Query: 721 FALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDI 764
F + +F+D ++WTD ++I + N+ G+ I + LN P DI
Sbjct: 632 FGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDI 675
Score = 220 bits (538), Expect = 3e-56
Identities = 124/349 (35%), Positives = 192/349 (55%), Gaps = 25/349 (7%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC--ADGPINYLIFAHRVDIRVISLDVP 1078
K+ CS +C+ G C C G +++ K C A G LIF +R ++R I L V
Sbjct: 381 KDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDL-VK 439
Query: 1079 YLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRA----TRLGTHVETVIGNGLH 1134
++P+ LKN + +DV+ +T IYW D RKI A E +I LH
Sbjct: 440 RNYSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH 497
Query: 1135 TADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWS 1194
+ +G+ +D + IYWTD G +I VA +DG R+ L L PRAIA+ G+M+WS
Sbjct: 498 SPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWS 557
Query: 1195 DWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHD 1254
DWG AKIE++ ++G +R+ +V + I+WPNG+ +D + RLYW D+K+ + S DF G +
Sbjct: 558 DWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGN 617
Query: 1255 RRTVLSN---VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDI-- 1309
R+T++S+ + +P+GI + ++WTD + +A+ A++ N + ++ +NL DI
Sbjct: 618 RKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVI 677
Query: 1310 -RAIQSERVLENACGTD---NGGCSHLCLRSPL------GYTCACPTGM 1348
++ R +AC NGGC +LCL +P YTCACP M
Sbjct: 678 FHELKQPRA-PDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTM 725
Score = 206 bits (504), Expect = 4e-52
Identities = 118/348 (33%), Positives = 186/348 (53%), Gaps = 23/348 (6%)
Query: 1325 DNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLE 1384
D CS +C+ + C C G + T + KS P LIF R + I L
Sbjct: 382 DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKS-PS--LIFTNRHEVRRIDLV 438
Query: 1385 SPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESK---TIISQK 1441
+ +P+ +KN +A+D I++ DL I S M S+ K +I ++
Sbjct: 439 K-RNYSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQ 495
Query: 1442 LETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLIT-GLTEPRALALFPAKGYLY 1500
L +P GL VDW+ +IYWTD+ +K I VA +DG R+ L + L+EPRA+A+ P +G++Y
Sbjct: 496 LHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMY 555
Query: 1501 WSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNG 1560
WSDWG+ IE+S L+G RQ +V ++ +PNG+T+D +RLYW D+ ++ + D +G
Sbjct: 556 WSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSG 615
Query: 1561 QHRVQLVPDA---KNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEI 1617
+R L+ +PFG+ F+D ++WTD ++I A++ G I+++ NL +I
Sbjct: 616 GNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDI 675
Query: 1618 KAVSADRQ-HGWNPCK---ESNGGCSHLCL----FRGH--EYICACPD 1655
+Q + C+ + NGGC +LCL H +Y CACPD
Sbjct: 676 VIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPD 723
Score = 176 bits (428), Expect = 7e-43
Identities = 111/338 (32%), Positives = 167/338 (49%), Gaps = 47/338 (13%)
Query: 762 MDIHSRSCEETPEKL--LLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQK 819
MD+ +++C+ K L++ R ++R L + + +IP+ +K+ VALD +
Sbjct: 407 MDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKR----NYSRLIPM--LKNVVALDVEVA 460
Query: 820 SNSIFWTDVEKDTINRAYLNGS----HQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNR 875
+N I+W D+ I AY++ + Q ++D L P GLA DW+ IYWTD G
Sbjct: 461 TNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKT 520
Query: 876 IEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIF 935
I V+ DG R L ++ +PR I V+P G MYWSDWG IE++ ++G +R+ L+
Sbjct: 521 ISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVS 580
Query: 936 GQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN---LPHPFGLDLYGDE 992
+ WPNG+ LDL+ R+YW D + + G R LI + L HPFG+ ++ D+
Sbjct: 581 DNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDK 640
Query: 993 VFWTDWDTQSIQAANKDTGAKRRTLGCGKN--------------------------NGGC 1026
VFWTD + ++I +AN+ G + L N NGGC
Sbjct: 641 VFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGC 700
Query: 1027 SHLCLLKPGGRS------CACPIGIKLNKDGKTCADGP 1058
+LCL P S CACP + L D K C P
Sbjct: 701 EYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAP 738
Score = 140 bits (338), Expect = 5e-32
Identities = 62/167 (37%), Positives = 88/167 (52%), Gaps = 14/167 (8%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C + F+C+N +C+P ++CD D+DC D +DED CP +C +F C++G CI ERW+
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKTCADSDFTCDNGHCIHERWK 104
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTC--ADRRCVLKTWLCDGVRDCTNGEDEMNC 380
CD E +C DG DE + C ++ +C +CV +W CDG +DC G DE C
Sbjct: 105 CDGEEECPDGSDESEATCTK-QVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
Query: 381 EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC 427
C ++ C R+C+ VCDG DC G DE C
Sbjct: 164 ATLCAPHEFQC---------GNRSCLAAVFVCDGDDDCGDGSDERGC 201
Score = 102 bits (245), Expect = 1e-20
Identities = 77/281 (27%), Positives = 127/281 (45%), Gaps = 18/281 (6%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVP 1078
C NNGGCSH+C G C CP G +L D KTC D I+ ++
Sbjct: 340 CLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGD--IDECKDPDACSQICVNYKGY 396
Query: 1079 YLIDVV--LPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTA 1136
+ + + L S LI+ T + +++R + + +I L
Sbjct: 397 FKCECYPGYEMDLLTKNCKAAAGKSPSLIF---TNRHEVRRIDLVKRNYSRLIPM-LKNV 452
Query: 1137 DGIVIDSTGRKIYWTDGGRNSIEVAEL----DGRNRKVLVWTGLDSPRAIALHYEYGYMF 1192
+ ++ +IYW D I A + D + ++VL+ L SP +A+ + + +++
Sbjct: 453 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
Query: 1193 WSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFD 1251
W+D G I A +DG RR + + P +A+D + G +YW+D IE S +
Sbjct: 513 WTDSGNKT-ISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 571
Query: 1252 GHDRRTVLS-NVPYPYGIV--IVGQHIYWTDWKTKALHRAD 1289
G DR+T++S N+ +P GI ++ Q +YW D K L D
Sbjct: 572 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSID 612
Score = 91.5 bits (217), Expect = 3e-17
Identities = 82/297 (27%), Positives = 129/297 (43%), Gaps = 21/297 (7%)
Query: 1320 NACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSIT 1379
N C +NGGCSH+C +G+ C CP G T +CK P+
Sbjct: 338 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD-PDACSQICVNYK-G 395
Query: 1380 YISLESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIIS 1439
Y E +++ L K K +IF + + +R I++ + S+ I
Sbjct: 396 YFKCECYPGYEMDLLTKNCKAAAGK----SPSLIF---TNRHEVRRIDLVKRNYSRLI-- 446
Query: 1440 QKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSS----RKVLI-TGLTEPRALALFP 1494
L+ L V+ N IYW D ++ I A +D +S ++VLI L P LA+
Sbjct: 447 PMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDW 506
Query: 1495 AKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTD-ALKDRI 1553
++YW+D G + I + +DG +R+ + +L P + +D +YW+D + +I
Sbjct: 507 VHKHIYWTDSG-NKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKI 565
Query: 1554 DTSDLNGQHRVQLVPD-AKNPFGMT--QFKDYIYWTDWYKKSIIRADKRTGKNITLI 1607
+ S LNG R LV D + P G+T +YW D + D G TLI
Sbjct: 566 EKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLI 622
Score = 65.3 bits (152), Expect = 2e-09
Identities = 31/96 (32%), Positives = 51/96 (53%), Gaps = 11/96 (11%)
Query: 344 RNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC-EVSCEEDQYTCRPQEHLMSNAF 402
++C D++ C + RC+ W CD DC + DE +C + +C + +TC N
Sbjct: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-------DNG- 96
Query: 403 RNCVNRKHVCDGMKDCPRGDDE-ERCPLKRKCSAEE 437
+C++ + CDG ++CP G DE E K+ C AE+
Sbjct: 97 -HCIHERWKCDGEEECPDGSDESEATCTKQVCPAEK 131
Score = 54.0 bits (124), Expect = 5e-06
Identities = 54/233 (23%), Positives = 102/233 (43%), Gaps = 20/233 (8%)
Query: 680 LTIDYTESKIYWADAKHHVIERA----AFDGRDRRKVTTKGL--PHPFALTLFDDAIYWT 733
L ++ ++IYW D + I A A D +++ + + L P A+ IYWT
Sbjct: 455 LDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWT 514
Query: 734 DWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESK 793
D K+IS + G L+ P R+ P + +Y D + K
Sbjct: 515 DSGNKTISVATVDGGRRRTLFSRNLSEP-----RAIAVDPLRGFMYW--SDWGDQAKIEK 567
Query: 794 KPIDSLD-MVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSN-- 850
++ +D + + I+ + D S ++W D + ++ +G ++ T++ S
Sbjct: 568 SGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDF 627
Query: 851 LIWPAGLAFDWITDKIYWTDGGTNRI-EVSKSDGSMRTLLAWDHIDKPRDIVV 902
L P G+A DK++WTD I ++ +G ++LA ++++ P DIV+
Sbjct: 628 LSHPFGIAV--FEDKVFWTDLENEAIFSANRLNGLEISILA-ENLNNPHDIVI 677
Score = 41.9 bits (94), Expect = 0.020
Identities = 28/88 (31%), Positives = 37/88 (42%), Gaps = 5/88 (5%)
Query: 110 EDDAGCITP-CLKINFSC-QISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTIC 167
E +A C C SC S C+P R C HE + C
Sbjct: 117 ESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQ--C 174
Query: 168 HSTNVCIALEWLCDGDNDCGDFSDEINC 195
+ + C+A ++CDGD+DCGD SDE C
Sbjct: 175 GNRS-CLAAVFVCDGDDDCGDGSDERGC 201
Score = 39.5 bits (88), Expect = 0.11
Identities = 14/23 (60%), Positives = 16/23 (69%)
Query: 173 CIALEWLCDGDNDCGDFSDEINC 195
C+ L W CDGD DC D SDE +C
Sbjct: 272 CVHLGWRCDGDRDCKDKSDEADC 294
Score = 37.9 bits (84), Expect = 0.33
Identities = 24/86 (27%), Positives = 28/86 (32%)
Query: 107 EGTEDDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTI 166
EG D+AGC T C F C + +C E R
Sbjct: 155 EGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCG 214
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDE 192
CI W+CD DC D SDE
Sbjct: 215 GDGGGACIPERWVCDRQFDCEDRSDE 240
Score = 35.9 bits (79), Expect = 1.3
Identities = 13/28 (46%), Positives = 16/28 (57%)
Query: 1627 GWNPCKESNGGCSHLCLFRGHEYICACP 1654
G N C +NGGCSH+C + C CP
Sbjct: 336 GLNECLHNNGGCSHICTDLKIGFECTCP 363
>AL355483-2|CAI22780.1| 904|Homo sapiens low density lipoprotein
receptor-related protein 8, apolipoprotein e receptor
protein.
Length = 904
Score = 365 bits (897), Expect = 1e-99
Identities = 195/524 (37%), Positives = 281/524 (53%), Gaps = 37/524 (7%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND---GKCIPE 319
CA +F+C N C+ F CDGD+DCGD +DE C +C EF+C G CIPE
Sbjct: 167 CAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC--ADPACGPREFRCGGDGGGACIPE 224
Query: 320 RWRCDNERDCADGGDE---LNCKP-----NSIRNCSL-DEYTCADRRCVLKTWLCDGVRD 370
RW CD + DC D DE L +P ++ C+ ++ C CV W CDG RD
Sbjct: 225 RWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRD 284
Query: 371 CTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC--P 428
C + DE +C + TCR E + CV C+ +DCP G DE C
Sbjct: 285 CKDKSDEADCPLG------TCRGDEFQCGDG--TCVLAIKHCNQEQDCPDGSDEAGCLQG 336
Query: 429 LKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQTCS 487
L C +C G C CP GF L + K +C DIDEC +DP CSQ C
Sbjct: 337 LNECLHNNGGCSHICTDLKIGFE-CTCPAGFQLLDQK-TCGDIDEC---KDPDACSQICV 391
Query: 488 NTVGSFRCGCMTGYILRPDERSCKPT-GESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHN 546
N G F+C C GY + ++CK G+SP+L+F+NR +R++ L NY ++ L N
Sbjct: 392 NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKN 451
Query: 547 AVALDYHYEKKLVFWSENNLRVIRVAQMNT----KNMSDVIRWGLETPAGVAVDWIHDLL 602
VALD ++W + + R I A M+ K +I L +P G+AVDW+H +
Sbjct: 452 VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 511
Query: 603 FWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMD 662
+WTDSG + + VAT+DG +R L + +L +PRAIAV P ++W+DWG KIE++ ++
Sbjct: 512 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 571
Query: 663 GDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKV--TTKGLPHP 720
G R+T++ D I WPNG+T+D ++YW D+K H + F G +R+ + +T L HP
Sbjct: 572 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 631
Query: 721 FALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDI 764
F + +F+D ++WTD ++I + N+ G+ I + LN P DI
Sbjct: 632 FGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDI 675
Score = 220 bits (538), Expect = 3e-56
Identities = 124/349 (35%), Positives = 192/349 (55%), Gaps = 25/349 (7%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC--ADGPINYLIFAHRVDIRVISLDVP 1078
K+ CS +C+ G C C G +++ K C A G LIF +R ++R I L V
Sbjct: 381 KDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDL-VK 439
Query: 1079 YLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRA----TRLGTHVETVIGNGLH 1134
++P+ LKN + +DV+ +T IYW D RKI A E +I LH
Sbjct: 440 RNYSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH 497
Query: 1135 TADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWS 1194
+ +G+ +D + IYWTD G +I VA +DG R+ L L PRAIA+ G+M+WS
Sbjct: 498 SPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWS 557
Query: 1195 DWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHD 1254
DWG AKIE++ ++G +R+ +V + I+WPNG+ +D + RLYW D+K+ + S DF G +
Sbjct: 558 DWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGN 617
Query: 1255 RRTVLSN---VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDI-- 1309
R+T++S+ + +P+GI + ++WTD + +A+ A++ N + ++ +NL DI
Sbjct: 618 RKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVI 677
Query: 1310 -RAIQSERVLENACGTD---NGGCSHLCLRSPL------GYTCACPTGM 1348
++ R +AC NGGC +LCL +P YTCACP M
Sbjct: 678 FHELKQPRA-PDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTM 725
Score = 206 bits (504), Expect = 4e-52
Identities = 118/348 (33%), Positives = 186/348 (53%), Gaps = 23/348 (6%)
Query: 1325 DNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLE 1384
D CS +C+ + C C G + T + KS P LIF R + I L
Sbjct: 382 DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKS-PS--LIFTNRHEVRRIDLV 438
Query: 1385 SPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESK---TIISQK 1441
+ +P+ +KN +A+D I++ DL I S M S+ K +I ++
Sbjct: 439 K-RNYSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQ 495
Query: 1442 LETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLIT-GLTEPRALALFPAKGYLY 1500
L +P GL VDW+ +IYWTD+ +K I VA +DG R+ L + L+EPRA+A+ P +G++Y
Sbjct: 496 LHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMY 555
Query: 1501 WSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNG 1560
WSDWG+ IE+S L+G RQ +V ++ +PNG+T+D +RLYW D+ ++ + D +G
Sbjct: 556 WSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSG 615
Query: 1561 QHRVQLVPDA---KNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEI 1617
+R L+ +PFG+ F+D ++WTD ++I A++ G I+++ NL +I
Sbjct: 616 GNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDI 675
Query: 1618 KAVSADRQ-HGWNPCK---ESNGGCSHLCL----FRGH--EYICACPD 1655
+Q + C+ + NGGC +LCL H +Y CACPD
Sbjct: 676 VIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPD 723
Score = 176 bits (428), Expect = 7e-43
Identities = 111/338 (32%), Positives = 167/338 (49%), Gaps = 47/338 (13%)
Query: 762 MDIHSRSCEETPEKL--LLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQK 819
MD+ +++C+ K L++ R ++R L + + +IP+ +K+ VALD +
Sbjct: 407 MDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKR----NYSRLIPM--LKNVVALDVEVA 460
Query: 820 SNSIFWTDVEKDTINRAYLNGS----HQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNR 875
+N I+W D+ I AY++ + Q ++D L P GLA DW+ IYWTD G
Sbjct: 461 TNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKT 520
Query: 876 IEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIF 935
I V+ DG R L ++ +PR I V+P G MYWSDWG IE++ ++G +R+ L+
Sbjct: 521 ISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVS 580
Query: 936 GQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN---LPHPFGLDLYGDE 992
+ WPNG+ LDL+ R+YW D + + G R LI + L HPFG+ ++ D+
Sbjct: 581 DNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDK 640
Query: 993 VFWTDWDTQSIQAANKDTGAKRRTLGCGKN--------------------------NGGC 1026
VFWTD + ++I +AN+ G + L N NGGC
Sbjct: 641 VFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGC 700
Query: 1027 SHLCLLKPGGRS------CACPIGIKLNKDGKTCADGP 1058
+LCL P S CACP + L D K C P
Sbjct: 701 EYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAP 738
Score = 140 bits (338), Expect = 5e-32
Identities = 62/167 (37%), Positives = 88/167 (52%), Gaps = 14/167 (8%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C + F+C+N +C+P ++CD D+DC D +DED CP +C +F C++G CI ERW+
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKTCADSDFTCDNGHCIHERWK 104
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTC--ADRRCVLKTWLCDGVRDCTNGEDEMNC 380
CD E +C DG DE + C ++ +C +CV +W CDG +DC G DE C
Sbjct: 105 CDGEEECPDGSDESEATCTK-QVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
Query: 381 EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC 427
C ++ C R+C+ VCDG DC G DE C
Sbjct: 164 ATLCAPHEFQC---------GNRSCLAAVFVCDGDDDCGDGSDERGC 201
Score = 102 bits (245), Expect = 1e-20
Identities = 77/281 (27%), Positives = 127/281 (45%), Gaps = 18/281 (6%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVP 1078
C NNGGCSH+C G C CP G +L D KTC D I+ ++
Sbjct: 340 CLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGD--IDECKDPDACSQICVNYKGY 396
Query: 1079 YLIDVV--LPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTA 1136
+ + + L S LI+ T + +++R + + +I L
Sbjct: 397 FKCECYPGYEMDLLTKNCKAAAGKSPSLIF---TNRHEVRRIDLVKRNYSRLIPM-LKNV 452
Query: 1137 DGIVIDSTGRKIYWTDGGRNSIEVAEL----DGRNRKVLVWTGLDSPRAIALHYEYGYMF 1192
+ ++ +IYW D I A + D + ++VL+ L SP +A+ + + +++
Sbjct: 453 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
Query: 1193 WSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFD 1251
W+D G I A +DG RR + + P +A+D + G +YW+D IE S +
Sbjct: 513 WTDSGNKT-ISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 571
Query: 1252 GHDRRTVLS-NVPYPYGIV--IVGQHIYWTDWKTKALHRAD 1289
G DR+T++S N+ +P GI ++ Q +YW D K L D
Sbjct: 572 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSID 612
Score = 91.5 bits (217), Expect = 3e-17
Identities = 82/297 (27%), Positives = 129/297 (43%), Gaps = 21/297 (7%)
Query: 1320 NACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSIT 1379
N C +NGGCSH+C +G+ C CP G T +CK P+
Sbjct: 338 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD-PDACSQICVNYK-G 395
Query: 1380 YISLESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIIS 1439
Y E +++ L K K +IF + + +R I++ + S+ I
Sbjct: 396 YFKCECYPGYEMDLLTKNCKAAAGK----SPSLIF---TNRHEVRRIDLVKRNYSRLI-- 446
Query: 1440 QKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSS----RKVLI-TGLTEPRALALFP 1494
L+ L V+ N IYW D ++ I A +D +S ++VLI L P LA+
Sbjct: 447 PMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDW 506
Query: 1495 AKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTD-ALKDRI 1553
++YW+D G + I + +DG +R+ + +L P + +D +YW+D + +I
Sbjct: 507 VHKHIYWTDSG-NKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKI 565
Query: 1554 DTSDLNGQHRVQLVPD-AKNPFGMT--QFKDYIYWTDWYKKSIIRADKRTGKNITLI 1607
+ S LNG R LV D + P G+T +YW D + D G TLI
Sbjct: 566 EKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLI 622
Score = 65.3 bits (152), Expect = 2e-09
Identities = 31/96 (32%), Positives = 51/96 (53%), Gaps = 11/96 (11%)
Query: 344 RNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC-EVSCEEDQYTCRPQEHLMSNAF 402
++C D++ C + RC+ W CD DC + DE +C + +C + +TC N
Sbjct: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-------DNG- 96
Query: 403 RNCVNRKHVCDGMKDCPRGDDE-ERCPLKRKCSAEE 437
+C++ + CDG ++CP G DE E K+ C AE+
Sbjct: 97 -HCIHERWKCDGEEECPDGSDESEATCTKQVCPAEK 131
Score = 54.0 bits (124), Expect = 5e-06
Identities = 54/233 (23%), Positives = 102/233 (43%), Gaps = 20/233 (8%)
Query: 680 LTIDYTESKIYWADAKHHVIERA----AFDGRDRRKVTTKGL--PHPFALTLFDDAIYWT 733
L ++ ++IYW D + I A A D +++ + + L P A+ IYWT
Sbjct: 455 LDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWT 514
Query: 734 DWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESK 793
D K+IS + G L+ P R+ P + +Y D + K
Sbjct: 515 DSGNKTISVATVDGGRRRTLFSRNLSEP-----RAIAVDPLRGFMYW--SDWGDQAKIEK 567
Query: 794 KPIDSLD-MVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSN-- 850
++ +D + + I+ + D S ++W D + ++ +G ++ T++ S
Sbjct: 568 SGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDF 627
Query: 851 LIWPAGLAFDWITDKIYWTDGGTNRI-EVSKSDGSMRTLLAWDHIDKPRDIVV 902
L P G+A DK++WTD I ++ +G ++LA ++++ P DIV+
Sbjct: 628 LSHPFGIAV--FEDKVFWTDLENEAIFSANRLNGLEISILA-ENLNNPHDIVI 677
Score = 41.9 bits (94), Expect = 0.020
Identities = 28/88 (31%), Positives = 37/88 (42%), Gaps = 5/88 (5%)
Query: 110 EDDAGCITP-CLKINFSC-QISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTIC 167
E +A C C SC S C+P R C HE + C
Sbjct: 117 ESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQ--C 174
Query: 168 HSTNVCIALEWLCDGDNDCGDFSDEINC 195
+ + C+A ++CDGD+DCGD SDE C
Sbjct: 175 GNRS-CLAAVFVCDGDDDCGDGSDERGC 201
Score = 39.5 bits (88), Expect = 0.11
Identities = 14/23 (60%), Positives = 16/23 (69%)
Query: 173 CIALEWLCDGDNDCGDFSDEINC 195
C+ L W CDGD DC D SDE +C
Sbjct: 272 CVHLGWRCDGDRDCKDKSDEADC 294
Score = 37.9 bits (84), Expect = 0.33
Identities = 24/86 (27%), Positives = 28/86 (32%)
Query: 107 EGTEDDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTI 166
EG D+AGC T C F C + +C E R
Sbjct: 155 EGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCG 214
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDE 192
CI W+CD DC D SDE
Sbjct: 215 GDGGGACIPERWVCDRQFDCEDRSDE 240
Score = 35.9 bits (79), Expect = 1.3
Identities = 13/28 (46%), Positives = 16/28 (57%)
Query: 1627 GWNPCKESNGGCSHLCLFRGHEYICACP 1654
G N C +NGGCSH+C + C CP
Sbjct: 336 GLNECLHNNGGCSHICTDLKIGFECTCP 363
>AL355483-1|CAI22781.1| 963|Homo sapiens low density lipoprotein
receptor-related protein 8, apolipoprotein e receptor
protein.
Length = 963
Score = 365 bits (897), Expect = 1e-99
Identities = 195/524 (37%), Positives = 281/524 (53%), Gaps = 37/524 (7%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND---GKCIPE 319
CA +F+C N C+ F CDGD+DCGD +DE C +C EF+C G CIPE
Sbjct: 167 CAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC--ADPACGPREFRCGGDGGGACIPE 224
Query: 320 RWRCDNERDCADGGDE---LNCKP-----NSIRNCSL-DEYTCADRRCVLKTWLCDGVRD 370
RW CD + DC D DE L +P ++ C+ ++ C CV W CDG RD
Sbjct: 225 RWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRD 284
Query: 371 CTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC--P 428
C + DE +C + TCR E + CV C+ +DCP G DE C
Sbjct: 285 CKDKSDEADCPLG------TCRGDEFQCGDG--TCVLAIKHCNQEQDCPDGSDEAGCLQG 336
Query: 429 LKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQTCS 487
L C +C G C CP GF L + K +C DIDEC +DP CSQ C
Sbjct: 337 LNECLHNNGGCSHICTDLKIGFE-CTCPAGFQLLDQK-TCGDIDEC---KDPDACSQICV 391
Query: 488 NTVGSFRCGCMTGYILRPDERSCKPT-GESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHN 546
N G F+C C GY + ++CK G+SP+L+F+NR +R++ L NY ++ L N
Sbjct: 392 NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKN 451
Query: 547 AVALDYHYEKKLVFWSENNLRVIRVAQMNT----KNMSDVIRWGLETPAGVAVDWIHDLL 602
VALD ++W + + R I A M+ K +I L +P G+AVDW+H +
Sbjct: 452 VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 511
Query: 603 FWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMD 662
+WTDSG + + VAT+DG +R L + +L +PRAIAV P ++W+DWG KIE++ ++
Sbjct: 512 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 571
Query: 663 GDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKV--TTKGLPHP 720
G R+T++ D I WPNG+T+D ++YW D+K H + F G +R+ + +T L HP
Sbjct: 572 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 631
Query: 721 FALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDI 764
F + +F+D ++WTD ++I + N+ G+ I + LN P DI
Sbjct: 632 FGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDI 675
Score = 220 bits (538), Expect = 3e-56
Identities = 124/349 (35%), Positives = 192/349 (55%), Gaps = 25/349 (7%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC--ADGPINYLIFAHRVDIRVISLDVP 1078
K+ CS +C+ G C C G +++ K C A G LIF +R ++R I L V
Sbjct: 381 KDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDL-VK 439
Query: 1079 YLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRA----TRLGTHVETVIGNGLH 1134
++P+ LKN + +DV+ +T IYW D RKI A E +I LH
Sbjct: 440 RNYSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH 497
Query: 1135 TADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWS 1194
+ +G+ +D + IYWTD G +I VA +DG R+ L L PRAIA+ G+M+WS
Sbjct: 498 SPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWS 557
Query: 1195 DWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHD 1254
DWG AKIE++ ++G +R+ +V + I+WPNG+ +D + RLYW D+K+ + S DF G +
Sbjct: 558 DWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGN 617
Query: 1255 RRTVLSN---VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDI-- 1309
R+T++S+ + +P+GI + ++WTD + +A+ A++ N + ++ +NL DI
Sbjct: 618 RKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVI 677
Query: 1310 -RAIQSERVLENACGTD---NGGCSHLCLRSPL------GYTCACPTGM 1348
++ R +AC NGGC +LCL +P YTCACP M
Sbjct: 678 FHELKQPRA-PDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTM 725
Score = 206 bits (504), Expect = 4e-52
Identities = 118/348 (33%), Positives = 186/348 (53%), Gaps = 23/348 (6%)
Query: 1325 DNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLE 1384
D CS +C+ + C C G + T + KS P LIF R + I L
Sbjct: 382 DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKS-PS--LIFTNRHEVRRIDLV 438
Query: 1385 SPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESK---TIISQK 1441
+ +P+ +KN +A+D I++ DL I S M S+ K +I ++
Sbjct: 439 K-RNYSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQ 495
Query: 1442 LETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLIT-GLTEPRALALFPAKGYLY 1500
L +P GL VDW+ +IYWTD+ +K I VA +DG R+ L + L+EPRA+A+ P +G++Y
Sbjct: 496 LHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMY 555
Query: 1501 WSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNG 1560
WSDWG+ IE+S L+G RQ +V ++ +PNG+T+D +RLYW D+ ++ + D +G
Sbjct: 556 WSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSG 615
Query: 1561 QHRVQLVPDA---KNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEI 1617
+R L+ +PFG+ F+D ++WTD ++I A++ G I+++ NL +I
Sbjct: 616 GNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDI 675
Query: 1618 KAVSADRQ-HGWNPCK---ESNGGCSHLCL----FRGH--EYICACPD 1655
+Q + C+ + NGGC +LCL H +Y CACPD
Sbjct: 676 VIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPD 723
Score = 176 bits (428), Expect = 7e-43
Identities = 111/338 (32%), Positives = 167/338 (49%), Gaps = 47/338 (13%)
Query: 762 MDIHSRSCEETPEKL--LLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQK 819
MD+ +++C+ K L++ R ++R L + + +IP+ +K+ VALD +
Sbjct: 407 MDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKR----NYSRLIPM--LKNVVALDVEVA 460
Query: 820 SNSIFWTDVEKDTINRAYLNGS----HQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNR 875
+N I+W D+ I AY++ + Q ++D L P GLA DW+ IYWTD G
Sbjct: 461 TNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKT 520
Query: 876 IEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIF 935
I V+ DG R L ++ +PR I V+P G MYWSDWG IE++ ++G +R+ L+
Sbjct: 521 ISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVS 580
Query: 936 GQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN---LPHPFGLDLYGDE 992
+ WPNG+ LDL+ R+YW D + + G R LI + L HPFG+ ++ D+
Sbjct: 581 DNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDK 640
Query: 993 VFWTDWDTQSIQAANKDTGAKRRTLGCGKN--------------------------NGGC 1026
VFWTD + ++I +AN+ G + L N NGGC
Sbjct: 641 VFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGC 700
Query: 1027 SHLCLLKPGGRS------CACPIGIKLNKDGKTCADGP 1058
+LCL P S CACP + L D K C P
Sbjct: 701 EYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAP 738
Score = 140 bits (338), Expect = 5e-32
Identities = 62/167 (37%), Positives = 88/167 (52%), Gaps = 14/167 (8%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C + F+C+N +C+P ++CD D+DC D +DED CP +C +F C++G CI ERW+
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKTCADSDFTCDNGHCIHERWK 104
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTC--ADRRCVLKTWLCDGVRDCTNGEDEMNC 380
CD E +C DG DE + C ++ +C +CV +W CDG +DC G DE C
Sbjct: 105 CDGEEECPDGSDESEATCTK-QVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
Query: 381 EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC 427
C ++ C R+C+ VCDG DC G DE C
Sbjct: 164 ATLCAPHEFQC---------GNRSCLAAVFVCDGDDDCGDGSDERGC 201
Score = 102 bits (245), Expect = 1e-20
Identities = 77/281 (27%), Positives = 127/281 (45%), Gaps = 18/281 (6%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVP 1078
C NNGGCSH+C G C CP G +L D KTC D I+ ++
Sbjct: 340 CLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGD--IDECKDPDACSQICVNYKGY 396
Query: 1079 YLIDVV--LPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTA 1136
+ + + L S LI+ T + +++R + + +I L
Sbjct: 397 FKCECYPGYEMDLLTKNCKAAAGKSPSLIF---TNRHEVRRIDLVKRNYSRLIPM-LKNV 452
Query: 1137 DGIVIDSTGRKIYWTDGGRNSIEVAEL----DGRNRKVLVWTGLDSPRAIALHYEYGYMF 1192
+ ++ +IYW D I A + D + ++VL+ L SP +A+ + + +++
Sbjct: 453 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
Query: 1193 WSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFD 1251
W+D G I A +DG RR + + P +A+D + G +YW+D IE S +
Sbjct: 513 WTDSGNKT-ISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 571
Query: 1252 GHDRRTVLS-NVPYPYGIV--IVGQHIYWTDWKTKALHRAD 1289
G DR+T++S N+ +P GI ++ Q +YW D K L D
Sbjct: 572 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSID 612
Score = 91.5 bits (217), Expect = 3e-17
Identities = 82/297 (27%), Positives = 129/297 (43%), Gaps = 21/297 (7%)
Query: 1320 NACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSIT 1379
N C +NGGCSH+C +G+ C CP G T +CK P+
Sbjct: 338 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD-PDACSQICVNYK-G 395
Query: 1380 YISLESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIIS 1439
Y E +++ L K K +IF + + +R I++ + S+ I
Sbjct: 396 YFKCECYPGYEMDLLTKNCKAAAGK----SPSLIF---TNRHEVRRIDLVKRNYSRLI-- 446
Query: 1440 QKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSS----RKVLI-TGLTEPRALALFP 1494
L+ L V+ N IYW D ++ I A +D +S ++VLI L P LA+
Sbjct: 447 PMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDW 506
Query: 1495 AKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTD-ALKDRI 1553
++YW+D G + I + +DG +R+ + +L P + +D +YW+D + +I
Sbjct: 507 VHKHIYWTDSG-NKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKI 565
Query: 1554 DTSDLNGQHRVQLVPD-AKNPFGMT--QFKDYIYWTDWYKKSIIRADKRTGKNITLI 1607
+ S LNG R LV D + P G+T +YW D + D G TLI
Sbjct: 566 EKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLI 622
Score = 65.3 bits (152), Expect = 2e-09
Identities = 31/96 (32%), Positives = 51/96 (53%), Gaps = 11/96 (11%)
Query: 344 RNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC-EVSCEEDQYTCRPQEHLMSNAF 402
++C D++ C + RC+ W CD DC + DE +C + +C + +TC N
Sbjct: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-------DNG- 96
Query: 403 RNCVNRKHVCDGMKDCPRGDDE-ERCPLKRKCSAEE 437
+C++ + CDG ++CP G DE E K+ C AE+
Sbjct: 97 -HCIHERWKCDGEEECPDGSDESEATCTKQVCPAEK 131
Score = 54.0 bits (124), Expect = 5e-06
Identities = 54/233 (23%), Positives = 102/233 (43%), Gaps = 20/233 (8%)
Query: 680 LTIDYTESKIYWADAKHHVIERA----AFDGRDRRKVTTKGL--PHPFALTLFDDAIYWT 733
L ++ ++IYW D + I A A D +++ + + L P A+ IYWT
Sbjct: 455 LDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWT 514
Query: 734 DWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESK 793
D K+IS + G L+ P R+ P + +Y D + K
Sbjct: 515 DSGNKTISVATVDGGRRRTLFSRNLSEP-----RAIAVDPLRGFMYW--SDWGDQAKIEK 567
Query: 794 KPIDSLD-MVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSN-- 850
++ +D + + I+ + D S ++W D + ++ +G ++ T++ S
Sbjct: 568 SGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDF 627
Query: 851 LIWPAGLAFDWITDKIYWTDGGTNRI-EVSKSDGSMRTLLAWDHIDKPRDIVV 902
L P G+A DK++WTD I ++ +G ++LA ++++ P DIV+
Sbjct: 628 LSHPFGIAV--FEDKVFWTDLENEAIFSANRLNGLEISILA-ENLNNPHDIVI 677
Score = 41.9 bits (94), Expect = 0.020
Identities = 28/88 (31%), Positives = 37/88 (42%), Gaps = 5/88 (5%)
Query: 110 EDDAGCITP-CLKINFSC-QISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTIC 167
E +A C C SC S C+P R C HE + C
Sbjct: 117 ESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQ--C 174
Query: 168 HSTNVCIALEWLCDGDNDCGDFSDEINC 195
+ + C+A ++CDGD+DCGD SDE C
Sbjct: 175 GNRS-CLAAVFVCDGDDDCGDGSDERGC 201
Score = 39.5 bits (88), Expect = 0.11
Identities = 14/23 (60%), Positives = 16/23 (69%)
Query: 173 CIALEWLCDGDNDCGDFSDEINC 195
C+ L W CDGD DC D SDE +C
Sbjct: 272 CVHLGWRCDGDRDCKDKSDEADC 294
Score = 37.9 bits (84), Expect = 0.33
Identities = 24/86 (27%), Positives = 28/86 (32%)
Query: 107 EGTEDDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTI 166
EG D+AGC T C F C + +C E R
Sbjct: 155 EGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCG 214
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDE 192
CI W+CD DC D SDE
Sbjct: 215 GDGGGACIPERWVCDRQFDCEDRSDE 240
Score = 35.9 bits (79), Expect = 1.3
Identities = 13/28 (46%), Positives = 16/28 (57%)
Query: 1627 GWNPCKESNGGCSHLCLFRGHEYICACP 1654
G N C +NGGCSH+C + C CP
Sbjct: 336 GLNECLHNNGGCSHICTDLKIGFECTCP 363
>D86407-2|BAA21825.1| 793|Homo sapiens ApoER2delta4-7 protein.
Length = 793
Score = 347 bits (853), Expect = 2e-94
Identities = 173/474 (36%), Positives = 258/474 (54%), Gaps = 28/474 (5%)
Query: 304 CNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTW 363
C +F+C + +CIP WRCD + DC D DE +C + C+ ++TC + C+ + W
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPK---KTCADSDFTCDNGHCIHERW 103
Query: 364 LCDGVRDCTNGEDEMNCEVS---CEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPR 420
CDG +C +G DE + C ++ +C P H CV CDG KDC
Sbjct: 104 KCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSH-------KCVPASWRCDGEKDCEG 156
Query: 421 GDDEERCP--LKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQ 478
G DE C L C +C G C CP GF L + K +C DIDEC +
Sbjct: 157 GADEAGCATWLNECLHNNGGCSHICTDLKIGFE-CTCPAGFQLLDQK-TCGDIDEC---K 211
Query: 479 DP-VCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTG-ESPTLLFSNRIGIRQVWLTGDN 536
DP CSQ C N G F+C C GY + ++CK G +SP+L+F+NR +R++ L N
Sbjct: 212 DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAGGKSPSLIFTNRYEVRRIDLVKRN 271
Query: 537 YMSVVKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNT----KNMSDVIRWGLETPAG 592
Y ++ L N VALD ++W + + R I A M+ K +I L +P G
Sbjct: 272 YSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEG 331
Query: 593 VAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGP 652
+AVDW+H ++WTDSG + + VAT+DG +R L + +L +PRAIAV P ++W+DWG
Sbjct: 332 LAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGD 391
Query: 653 NPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKV 712
KIE++ ++G R+T++ D I WPNG+T+D ++YW D+K H + F G +R+ +
Sbjct: 392 QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTL 451
Query: 713 --TTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDI 764
+T L HPF + +F+D ++WTD ++I + N+ G+ I + LN P DI
Sbjct: 452 ISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDI 505
Score = 221 bits (541), Expect = 1e-56
Identities = 124/349 (35%), Positives = 192/349 (55%), Gaps = 25/349 (7%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC--ADGPINYLIFAHRVDIRVISLDVP 1078
K+ CS +C+ G C C G +++ K C A G LIF +R ++R I L V
Sbjct: 211 KDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAGGKSPSLIFTNRYEVRRIDL-VK 269
Query: 1079 YLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRA----TRLGTHVETVIGNGLH 1134
++P+ LKN + +DV+ +T IYW D RKI A E +I LH
Sbjct: 270 RNYSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH 327
Query: 1135 TADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWS 1194
+ +G+ +D + IYWTD G +I VA +DG R+ L L PRAIA+ G+M+WS
Sbjct: 328 SPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWS 387
Query: 1195 DWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHD 1254
DWG AKIE++ ++G +R+ +V + I+WPNG+ +D + RLYW D+K+ + S DF G +
Sbjct: 388 DWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGN 447
Query: 1255 RRTVLSN---VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDI-- 1309
R+T++S+ + +P+GI + ++WTD + +A+ A++ N + ++ +NL DI
Sbjct: 448 RKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVI 507
Query: 1310 -RAIQSERVLENACGTD---NGGCSHLCLRSPL------GYTCACPTGM 1348
++ R +AC NGGC +LCL +P YTCACP M
Sbjct: 508 FHELKQPRA-PDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTM 555
Score = 206 bits (503), Expect = 6e-52
Identities = 118/350 (33%), Positives = 186/350 (53%), Gaps = 27/350 (7%)
Query: 1325 DNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSH--PEEFLIFATRGSITYIS 1382
D CS +C+ + C C G + T K CK+ LIF R + I
Sbjct: 212 DPDACSQICVNYKGYFKCECYPGYEMDLLT-----KNCKAAGGKSPSLIFTNRYEVRRID 266
Query: 1383 LESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESK---TIIS 1439
L + +P+ +KN +A+D I++ DL I S M S+ K +I
Sbjct: 267 LVK-RNYSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLID 323
Query: 1440 QKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLIT-GLTEPRALALFPAKGY 1498
++L +P GL VDW+ +IYWTD+ +K I VA +DG R+ L + L+EPRA+A+ P +G+
Sbjct: 324 EQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGF 383
Query: 1499 LYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDL 1558
+YWSDWG+ IE+S L+G RQ +V ++ +PNG+T+D +RLYW D+ ++ + D
Sbjct: 384 MYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDF 443
Query: 1559 NGQHRVQLVPDA---KNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAM 1615
+G +R L+ +PFG+ F+D ++WTD ++I A++ G I+++ NL
Sbjct: 444 SGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPH 503
Query: 1616 EIKAVSADRQ-HGWNPCK---ESNGGCSHLCL----FRGH--EYICACPD 1655
+I +Q + C+ + NGGC +LCL H +Y CACPD
Sbjct: 504 DIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPD 553
Score = 175 bits (426), Expect = 1e-42
Identities = 111/338 (32%), Positives = 167/338 (49%), Gaps = 47/338 (13%)
Query: 762 MDIHSRSCEETPEKL--LLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQK 819
MD+ +++C+ K L++ R ++R L + + +IP+ +K+ VALD +
Sbjct: 237 MDLLTKNCKAAGGKSPSLIFTNRYEVRRIDLVKR----NYSRLIPM--LKNVVALDVEVA 290
Query: 820 SNSIFWTDVEKDTINRAYLNGS----HQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNR 875
+N I+W D+ I AY++ + Q ++D L P GLA DW+ IYWTD G
Sbjct: 291 TNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKT 350
Query: 876 IEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIF 935
I V+ DG R L ++ +PR I V+P G MYWSDWG IE++ ++G +R+ L+
Sbjct: 351 ISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVS 410
Query: 936 GQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN---LPHPFGLDLYGDE 992
+ WPNG+ LDL+ R+YW D + + G R LI + L HPFG+ ++ D+
Sbjct: 411 DNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDK 470
Query: 993 VFWTDWDTQSIQAANKDTGAKRRTLGCGKN--------------------------NGGC 1026
VFWTD + ++I +AN+ G + L N NGGC
Sbjct: 471 VFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGC 530
Query: 1027 SHLCLLKPGGRS------CACPIGIKLNKDGKTCADGP 1058
+LCL P S CACP + L D K C P
Sbjct: 531 EYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAP 568
Score = 131 bits (317), Expect = 2e-29
Identities = 73/223 (32%), Positives = 109/223 (48%), Gaps = 30/223 (13%)
Query: 247 AANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNA 306
AA+P P + C + F+C+N +C+P ++CD D+DC D +DED CP +C
Sbjct: 33 AADPLLGGQGPAK--ECEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKTCAD 88
Query: 307 GEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTC--ADRRCVLKTWL 364
+F C++G CI ERW+CD E +C DG DE + C ++ +C +CV +W
Sbjct: 89 SDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTK-QVCPAEKLSCGPTSHKCVPASWR 147
Query: 365 CDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMK-----DCP 419
CDG +DC G DE C E C L +N C H+C +K CP
Sbjct: 148 CDGEKDCEGGADEAGCATWLNE----C-----LHNNG--GC---SHICTDLKIGFECTCP 193
Query: 420 RGD---DEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGF 459
G D++ C +C + C ++C+ Y G+ C C G+
Sbjct: 194 AGFQLLDQKTCGDIDECKDPDACSQICV-NYKGYFKCECYPGY 235
Score = 101 bits (241), Expect = 3e-20
Identities = 77/281 (27%), Positives = 126/281 (44%), Gaps = 18/281 (6%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVP 1078
C NNGGCSH+C G C CP G +L D KTC D I+ ++
Sbjct: 170 CLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGD--IDECKDPDACSQICVNYKGY 226
Query: 1079 YLIDVV--LPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTA 1136
+ + + L S LI+ R+I R + + ++ N +
Sbjct: 227 FKCECYPGYEMDLLTKNCKAAGGKSPSLIFTNRYEVRRIDLVKRNYSRLIPMLKNVV--- 283
Query: 1137 DGIVIDSTGRKIYWTDGGRNSIEVAEL----DGRNRKVLVWTGLDSPRAIALHYEYGYMF 1192
+ ++ +IYW D I A + D + ++VL+ L SP +A+ + + +++
Sbjct: 284 -ALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 342
Query: 1193 WSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFD 1251
W+D G I A +DG RR + + P +A+D + G +YW+D IE S +
Sbjct: 343 WTDSGNKT-ISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 401
Query: 1252 GHDRRTVLS-NVPYPYGIV--IVGQHIYWTDWKTKALHRAD 1289
G DR+T++S N+ +P GI ++ Q +YW D K L D
Sbjct: 402 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSID 442
Score = 90.2 bits (214), Expect = 6e-17
Identities = 82/297 (27%), Positives = 128/297 (43%), Gaps = 21/297 (7%)
Query: 1320 NACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSIT 1379
N C +NGGCSH+C +G+ C CP G T +CK P+
Sbjct: 168 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD-PDACSQICVNYK-G 225
Query: 1380 YISLESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIIS 1439
Y E +++ L K K +IF + +R I++ + S+ I
Sbjct: 226 YFKCECYPGYEMDLLTKNCKAAGGK----SPSLIFTNRYE---VRRIDLVKRNYSRLI-- 276
Query: 1440 QKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSS----RKVLI-TGLTEPRALALFP 1494
L+ L V+ N IYW D ++ I A +D +S ++VLI L P LA+
Sbjct: 277 PMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDW 336
Query: 1495 AKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTD-ALKDRI 1553
++YW+D G + I + +DG +R+ + +L P + +D +YW+D + +I
Sbjct: 337 VHKHIYWTDSG-NKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKI 395
Query: 1554 DTSDLNGQHRVQLVPD-AKNPFGMT--QFKDYIYWTDWYKKSIIRADKRTGKNITLI 1607
+ S LNG R LV D + P G+T +YW D + D G TLI
Sbjct: 396 EKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLI 452
Score = 54.0 bits (124), Expect = 5e-06
Identities = 54/233 (23%), Positives = 102/233 (43%), Gaps = 20/233 (8%)
Query: 680 LTIDYTESKIYWADAKHHVIERA----AFDGRDRRKVTTKGL--PHPFALTLFDDAIYWT 733
L ++ ++IYW D + I A A D +++ + + L P A+ IYWT
Sbjct: 285 LDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWT 344
Query: 734 DWHTKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESK 793
D K+IS + G L+ P R+ P + +Y D + K
Sbjct: 345 DSGNKTISVATVDGGRRRTLFSRNLSEP-----RAIAVDPLRGFMYW--SDWGDQAKIEK 397
Query: 794 KPIDSLD-MVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSN-- 850
++ +D + + I+ + D S ++W D + ++ +G ++ T++ S
Sbjct: 398 SGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDF 457
Query: 851 LIWPAGLAFDWITDKIYWTDGGTNRI-EVSKSDGSMRTLLAWDHIDKPRDIVV 902
L P G+A DK++WTD I ++ +G ++LA ++++ P DIV+
Sbjct: 458 LSHPFGIAV--FEDKVFWTDLENEAIFSANRLNGLEISILA-ENLNNPHDIVI 507
Score = 41.5 bits (93), Expect = 0.027
Identities = 37/134 (27%), Positives = 53/134 (39%), Gaps = 24/134 (17%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
CI W CD D+DC D SDE +C KT ++ + + G I
Sbjct: 59 CIPSVWRCDEDDDCLDHSDEDDCP-KKT---CADSDFTCDNGHCIHE------------- 101
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNT--KCVPKDFQCDGDNDCGD 290
R++ ++ D + +T + V C C T KCVP ++CDG+ DC
Sbjct: 102 -RWKCDGEEECPDGSDESEATCTKQV----CPAEKLSCGPTSHKCVPASWRCDGEKDCEG 156
Query: 291 WTDEDSCPMVPGSC 304
DE C C
Sbjct: 157 GADEAGCATWLNEC 170
Score = 34.7 bits (76), Expect = 3.1
Identities = 26/101 (25%), Positives = 40/101 (39%), Gaps = 8/101 (7%)
Query: 99 DPDDGPLNEGTEDDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSC 158
D DD L+ EDD T C +F+C + CI +R +C
Sbjct: 67 DEDDDCLDHSDEDDCPKKT-CADSDFTCD-NGHCI--HERWKCDGEEECPDGSDESEATC 122
Query: 159 DEH----ENRTICHSTNVCIALEWLCDGDNDCGDFSDEINC 195
+ E + +++ C+ W CDG+ DC +DE C
Sbjct: 123 TKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
Score = 34.3 bits (75), Expect = 4.0
Identities = 12/26 (46%), Positives = 15/26 (57%)
Query: 1629 NPCKESNGGCSHLCLFRGHEYICACP 1654
N C +NGGCSH+C + C CP
Sbjct: 168 NECLHNNGGCSHICTDLKIGFECTCP 193
>L00352-1|AAA56833.1| 860|Homo sapiens low density lipoprotein
receptor protein.
Length = 860
Score = 342 bits (841), Expect = 6e-93
Identities = 202/641 (31%), Positives = 302/641 (47%), Gaps = 76/641 (11%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
CI+ +W+CDG +C D SDE +T L V + + G + +
Sbjct: 39 CISYKWVCDGSAECQDGSDESQ----ETCLSVTCKSGDFSCGGRVNR-----------CI 83
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWT 292
++ + DN ++ Q C++ +F C + KC+ + F CD D DC D +
Sbjct: 84 PQFWRCDGQVDCDNGSD-----EQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGS 138
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDEL--NCK-----PNSIRN 345
DE SCP++ +C F+CN CIP+ W CDN+ DC DG DE C+
Sbjct: 139 DEASCPVL--TCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSP 196
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC--------EVSCEED---------- 387
CS E+ C C+ +W CDG DC + DE NC E C +
Sbjct: 197 CSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCD 256
Query: 388 -QYTCRPQEHLMS----------NAFR----NCVNRKHVCDGMKDCPRGDDE--ERCPLK 430
+Y C+ + N F+ C+ VC+ +DC DE + C
Sbjct: 257 REYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTN 316
Query: 431 RKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQTCSNT 489
C +C G+ C CP GF L + C DIDEC QDP CSQ C N
Sbjct: 317 ECLDNNGGCSHVCNDLKIGYE-CLCPDGFQLVAQR-RCEDIDEC---QDPDTCSQLCVNL 371
Query: 490 VGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVA 549
G ++C C G+ L P ++CK G L F+NR +R++ L Y S++ L N VA
Sbjct: 372 EGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVA 431
Query: 550 LDYHYEKKLVFWSENNLRVIRVAQMN----TKNMSDVIRWGLETPAGVAVDWIHDLLFWT 605
LD ++WS+ + R+I Q++ + VI ++ P G+AVDWIH ++WT
Sbjct: 432 LDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWT 491
Query: 606 DSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDK 665
DS V VA G KR L + KPRAI V P ++WTDWG KI++ ++G
Sbjct: 492 DSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVD 551
Query: 666 RKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKV--TTKGLPHPFAL 723
+++ + I WPNG+T+D ++YW D+K H I +G +R+ + K L HPF+L
Sbjct: 552 IYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSL 611
Query: 724 TLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDI 764
+F+D ++WTD ++I + N+ TG + + L P D+
Sbjct: 612 AVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDM 652
Score = 213 bits (519), Expect = 6e-54
Identities = 117/344 (34%), Positives = 188/344 (54%), Gaps = 26/344 (7%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGPINYLIFAHRVDIRVISLDVPYLIDVV 1084
CS LC+ GG C C G +L+ K C A G I YL F +R ++R ++LD ++
Sbjct: 364 CSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLI 423
Query: 1085 LPLPPLKNALGVDVDHSTGLIYWTDTGQRKI-----QRATRLGTHVETVIGNGLHTADGI 1139
P L+N + +D + ++ IYW+D QR I RA + ++ +TVI + DG+
Sbjct: 424 ---PNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSY-DTVISRDIQAPDGL 479
Query: 1140 VIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTS 1199
+D IYWTD ++ VA+ G RK L PRAI + +G+M+W+DWGT
Sbjct: 480 AVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTP 539
Query: 1200 AKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVL 1259
AKI++ ++G + +V I+WPNG+ +D + GRLYW D+K+ +I S D +G +R+T+L
Sbjct: 540 AKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTIL 599
Query: 1260 SN---VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNL---EGLMDIRAIQ 1313
+ + +P+ + + ++WTD +A+ A++ SD ++ +NL E ++ +
Sbjct: 600 EDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLT 659
Query: 1314 SERVLENAC---GTDNGGCSHLCLRSPL------GYTCACPTGM 1348
R + N C NGGC +LCL +P +TCACP GM
Sbjct: 660 QPRGV-NWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGM 702
Score = 194 bits (474), Expect = 2e-48
Identities = 113/349 (32%), Positives = 182/349 (52%), Gaps = 26/349 (7%)
Query: 1325 DNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPE-EFLIFATRGSITYISL 1383
D CS LC+ GY C C G + T K CK+ +L F R + ++L
Sbjct: 360 DPDTCSQLCVNLEGGYKCQCEEGFQLDPHT-----KACKAVGSIAYLFFTNRHEVRKMTL 414
Query: 1384 ESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTN---MSESKTIISQ 1440
+ E T + ++N +A+D I+++DL +I S + +S T+IS+
Sbjct: 415 DRSEY---TSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISR 471
Query: 1441 KLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLIT-GLTEPRALALFPAKGYL 1499
++ P+GL VDWI +NIYWTD+ + VA G RK L ++PRA+ + P G++
Sbjct: 472 DIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFM 531
Query: 1500 YWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLN 1559
YW+DWG I++ L+G +V ++ +PNG+T+D RLYW D+ I + D+N
Sbjct: 532 YWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVN 591
Query: 1560 GQHRVQLVPDAK---NPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAME 1616
G +R ++ D K +PF + F+D ++WTD ++I A++ TG ++ L+ NL +
Sbjct: 592 GGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPED 651
Query: 1617 IKAV-SADRQHGWNPCKE---SNGGCSHLCL----FRGH--EYICACPD 1655
+ + + G N C+ SNGGC +LCL H ++ CACPD
Sbjct: 652 MVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPD 700
Score = 168 bits (408), Expect = 2e-40
Identities = 103/333 (30%), Positives = 168/333 (50%), Gaps = 46/333 (13%)
Query: 762 MDIHSRSCEETPE-KLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKS 820
+D H+++C+ L + R ++R K +D + + +++ VALD + S
Sbjct: 385 LDPHTKACKAVGSIAYLFFTNRHEVR------KMTLDRSEYTSLIPNLRNVVALDTEVAS 438
Query: 821 NSIFWTDVEKDTINRAYLNGSHQT----TIVDSNLIWPAGLAFDWITDKIYWTDGGTNRI 876
N I+W+D+ + I L+ +H T++ ++ P GLA DWI IYWTD +
Sbjct: 439 NRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTV 498
Query: 877 EVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFG 936
V+ + G R L ++ KPR IVV+P G MYW+DWG I++ ++G + L+
Sbjct: 499 SVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTE 558
Query: 937 QMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN---LPHPFGLDLYGDEV 993
+ WPNG+ LDL+ R+YW D +I +++G R ++E+ L HPF L ++ D+V
Sbjct: 559 NIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKV 618
Query: 994 FWTDWDTQSIQAANKDTGAKRRTLG-----------------------CGK---NNGGCS 1027
FWTD ++I +AN+ TG+ L C + +NGGC
Sbjct: 619 FWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQ 678
Query: 1028 HLCLLKPGGR------SCACPIGIKLNKDGKTC 1054
+LCL P +CACP G+ L +D ++C
Sbjct: 679 YLCLPAPQINPHSPKFTCACPDGMLLARDMRSC 711
Score = 163 bits (396), Expect = 5e-39
Identities = 135/561 (24%), Positives = 235/561 (41%), Gaps = 56/561 (9%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
++C + E R CH CI+ +++CD D DC D SDE +C V+ N+S I
Sbjct: 107 KTCSQDEFR--CHDGK-CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCI-- 161
Query: 216 VITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKC 275
P + P C + + R + + C+ +F C + +C
Sbjct: 162 ----PQLWACDNDPD--------CEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGEC 209
Query: 276 VPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDE 335
+ ++CDG DC D +DE++C + +C EF+C+DG CI +CD E DC D DE
Sbjct: 210 IHSSWRCDGGPDCKDKSDEENCAV--ATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDE 267
Query: 336 LNCKPNSIRNC-SLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ 394
+ C ++ C +++ C C+ +C+ RDC + DE E C
Sbjct: 268 VGCV--NVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKE---------CGTN 316
Query: 395 EHLMSNAFRNCVNRKHVCDGMKD-----CPRGDD---EERCPLKRKCSAEEKCEKLCITT 446
E L +N C HVC+ +K CP G + RC +C + C +LC+
Sbjct: 317 ECLDNNG--GC---SHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNL 371
Query: 447 YDGHAACACPMGFLLAEDKYSCRDIDECMY----EQDPVCSQTCSNTVGSFRCGCMTGYI 502
G+ C C GF L +C+ + Y + V T + + + +
Sbjct: 372 EGGY-KCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVV 430
Query: 503 LRPDERSCKP---TGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLV 559
E + + S ++ S ++ + D +S + +A+D+ + +
Sbjct: 431 ALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSN--I 488
Query: 560 FWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGT-RRVEVATLD 618
+W+++ L + VA + R P + VD +H ++WTD GT +++ L+
Sbjct: 489 YWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLN 548
Query: 619 GSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPN 678
G LV ++ P I + ++W D I D++G RKT++ DE +
Sbjct: 549 GVDIYSLVTENIQWPNGITLDLLSGRLYWVD-SKLHSISSIDVNGGNRKTILEDEKRLAH 607
Query: 679 GLTIDYTESKIYWADAKHHVI 699
++ E K++W D + I
Sbjct: 608 PFSLAVFEDKVFWTDIINEAI 628
Score = 133 bits (321), Expect = 6e-30
Identities = 61/170 (35%), Positives = 92/170 (54%), Gaps = 15/170 (8%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND--GKCIPE 319
RC +F+C++ KC+ + CDG +C D +DE + +C +G+F C +CIP+
Sbjct: 26 RCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQ 85
Query: 320 RWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMN 379
WRCD + DC +G DE C P + CS DE+ C D +C+ + ++CD RDC +G DE +
Sbjct: 86 FWRCDGQVDCDNGSDEQGCPP---KTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEAS 142
Query: 380 CEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE--ERC 427
C V TC P +++ C+ + CD DC G DE +RC
Sbjct: 143 CPV------LTCGPASFQCNSS--TCIPQLWACDNDPDCEDGSDEWPQRC 184
Score = 108 bits (260), Expect = 2e-22
Identities = 53/145 (36%), Positives = 73/145 (50%), Gaps = 14/145 (9%)
Query: 304 CNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADR--RCVLK 361
C EF+C DGKCI +W CD +C DG DE S+ C +++C R RC+ +
Sbjct: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSV-TCKSGDFSCGGRVNRCIPQ 85
Query: 362 TWLCDGVRDCTNGEDEMNC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPR 420
W CDG DC NG DE C +C +D++ C + C++R+ VCD +DC
Sbjct: 86 FWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGK---------CISRQFVCDSDRDCLD 136
Query: 421 GDDEERCPLKRKCSAEEKC-EKLCI 444
G DE CP+ A +C CI
Sbjct: 137 GSDEASCPVLTCGPASFQCNSSTCI 161
Score = 69.7 bits (163), Expect = 9e-11
Identities = 60/279 (21%), Positives = 114/279 (40%), Gaps = 15/279 (5%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVP 1078
C NNGGCSH+C G C CP G +L + C D I+ ++L+
Sbjct: 318 CLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQ-RRCED--IDECQDPDTCSQLCVNLEGG 374
Query: 1079 YLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADG 1138
Y + S +++T+ + ++++ T + ++I N L
Sbjct: 375 YKCQCEEGFQLDPHTKACKAVGSIAYLFFTN--RHEVRKMTLDRSEYTSLIPN-LRNVVA 431
Query: 1139 IVIDSTGRKIYWTDGGRNSIEVAELDG----RNRKVLVWTGLDSPRAIALHYEYGYMFWS 1194
+ + +IYW+D + I +LD + ++ + +P +A+ + + ++W+
Sbjct: 432 LDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWT 491
Query: 1195 DWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFDGH 1253
D + AD G R+ + P + +D + G +YW D I+ +G
Sbjct: 492 D-SVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGV 550
Query: 1254 D-RRTVLSNVPYPYGIV--IVGQHIYWTDWKTKALHRAD 1289
D V N+ +P GI ++ +YW D K ++ D
Sbjct: 551 DIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSID 589
Score = 40.3 bits (90), Expect = 0.061
Identities = 22/58 (37%), Positives = 33/58 (56%), Gaps = 3/58 (5%)
Query: 1600 TGKNITLIRTNLEMAMEIKAVSAD--RQHGWNPCKESNGGCSHLCLFRGHEYICACPD 1655
+G+ ITL + MA + + S + ++ G N C ++NGGCSH+C Y C CPD
Sbjct: 286 SGECITLDKV-CNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPD 342
>BT007361-1|AAP36025.1| 860|Homo sapiens low density lipoprotein
receptor (familial hypercholesterolemia) protein.
Length = 860
Score = 342 bits (841), Expect = 6e-93
Identities = 202/641 (31%), Positives = 302/641 (47%), Gaps = 76/641 (11%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
CI+ +W+CDG +C D SDE +T L V + + G + +
Sbjct: 39 CISYKWVCDGSAECQDGSDESQ----ETCLSVTCKSGDFSCGGRVNR-----------CI 83
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWT 292
++ + DN ++ Q C++ +F C + KC+ + F CD D DC D +
Sbjct: 84 PQFWRCDGQVDCDNGSD-----EQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGS 138
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDEL--NCK-----PNSIRN 345
DE SCP++ +C F+CN CIP+ W CDN+ DC DG DE C+
Sbjct: 139 DEASCPVL--TCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSP 196
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC--------EVSCEED---------- 387
CS E+ C C+ +W CDG DC + DE NC E C +
Sbjct: 197 CSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCD 256
Query: 388 -QYTCRPQEHLMS----------NAFR----NCVNRKHVCDGMKDCPRGDDE--ERCPLK 430
+Y C+ + N F+ C+ VC+ +DC DE + C
Sbjct: 257 REYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTN 316
Query: 431 RKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQTCSNT 489
C +C G+ C CP GF L + C DIDEC QDP CSQ C N
Sbjct: 317 ECLDNNGGCSHVCNDLKIGYE-CLCPDGFQLVAQR-RCEDIDEC---QDPDTCSQLCVNL 371
Query: 490 VGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVA 549
G ++C C G+ L P ++CK G L F+NR +R++ L Y S++ L N VA
Sbjct: 372 EGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVA 431
Query: 550 LDYHYEKKLVFWSENNLRVIRVAQMN----TKNMSDVIRWGLETPAGVAVDWIHDLLFWT 605
LD ++WS+ + R+I Q++ + VI ++ P G+AVDWIH ++WT
Sbjct: 432 LDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWT 491
Query: 606 DSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDK 665
DS V VA G KR L + KPRAI V P ++WTDWG KI++ ++G
Sbjct: 492 DSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVD 551
Query: 666 RKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKV--TTKGLPHPFAL 723
+++ + I WPNG+T+D ++YW D+K H I +G +R+ + K L HPF+L
Sbjct: 552 IYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSL 611
Query: 724 TLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDI 764
+F+D ++WTD ++I + N+ TG + + L P D+
Sbjct: 612 AVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDM 652
Score = 213 bits (519), Expect = 6e-54
Identities = 117/344 (34%), Positives = 188/344 (54%), Gaps = 26/344 (7%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGPINYLIFAHRVDIRVISLDVPYLIDVV 1084
CS LC+ GG C C G +L+ K C A G I YL F +R ++R ++LD ++
Sbjct: 364 CSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLI 423
Query: 1085 LPLPPLKNALGVDVDHSTGLIYWTDTGQRKI-----QRATRLGTHVETVIGNGLHTADGI 1139
P L+N + +D + ++ IYW+D QR I RA + ++ +TVI + DG+
Sbjct: 424 ---PNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSY-DTVISRDIQAPDGL 479
Query: 1140 VIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTS 1199
+D IYWTD ++ VA+ G RK L PRAI + +G+M+W+DWGT
Sbjct: 480 AVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTP 539
Query: 1200 AKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVL 1259
AKI++ ++G + +V I+WPNG+ +D + GRLYW D+K+ +I S D +G +R+T+L
Sbjct: 540 AKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTIL 599
Query: 1260 SN---VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNL---EGLMDIRAIQ 1313
+ + +P+ + + ++WTD +A+ A++ SD ++ +NL E ++ +
Sbjct: 600 EDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLT 659
Query: 1314 SERVLENAC---GTDNGGCSHLCLRSPL------GYTCACPTGM 1348
R + N C NGGC +LCL +P +TCACP GM
Sbjct: 660 QPRGV-NWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGM 702
Score = 194 bits (474), Expect = 2e-48
Identities = 113/349 (32%), Positives = 182/349 (52%), Gaps = 26/349 (7%)
Query: 1325 DNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPE-EFLIFATRGSITYISL 1383
D CS LC+ GY C C G + T K CK+ +L F R + ++L
Sbjct: 360 DPDTCSQLCVNLEGGYKCQCEEGFQLDPHT-----KACKAVGSIAYLFFTNRHEVRKMTL 414
Query: 1384 ESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTN---MSESKTIISQ 1440
+ E T + ++N +A+D I+++DL +I S + +S T+IS+
Sbjct: 415 DRSEY---TSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISR 471
Query: 1441 KLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLIT-GLTEPRALALFPAKGYL 1499
++ P+GL VDWI +NIYWTD+ + VA G RK L ++PRA+ + P G++
Sbjct: 472 DIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFM 531
Query: 1500 YWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLN 1559
YW+DWG I++ L+G +V ++ +PNG+T+D RLYW D+ I + D+N
Sbjct: 532 YWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVN 591
Query: 1560 GQHRVQLVPDAK---NPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAME 1616
G +R ++ D K +PF + F+D ++WTD ++I A++ TG ++ L+ NL +
Sbjct: 592 GGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPED 651
Query: 1617 IKAV-SADRQHGWNPCKE---SNGGCSHLCL----FRGH--EYICACPD 1655
+ + + G N C+ SNGGC +LCL H ++ CACPD
Sbjct: 652 MVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPD 700
Score = 168 bits (408), Expect = 2e-40
Identities = 103/333 (30%), Positives = 168/333 (50%), Gaps = 46/333 (13%)
Query: 762 MDIHSRSCEETPE-KLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKS 820
+D H+++C+ L + R ++R K +D + + +++ VALD + S
Sbjct: 385 LDPHTKACKAVGSIAYLFFTNRHEVR------KMTLDRSEYTSLIPNLRNVVALDTEVAS 438
Query: 821 NSIFWTDVEKDTINRAYLNGSHQT----TIVDSNLIWPAGLAFDWITDKIYWTDGGTNRI 876
N I+W+D+ + I L+ +H T++ ++ P GLA DWI IYWTD +
Sbjct: 439 NRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTV 498
Query: 877 EVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFG 936
V+ + G R L ++ KPR IVV+P G MYW+DWG I++ ++G + L+
Sbjct: 499 SVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTE 558
Query: 937 QMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN---LPHPFGLDLYGDEV 993
+ WPNG+ LDL+ R+YW D +I +++G R ++E+ L HPF L ++ D+V
Sbjct: 559 NIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKV 618
Query: 994 FWTDWDTQSIQAANKDTGAKRRTLG-----------------------CGK---NNGGCS 1027
FWTD ++I +AN+ TG+ L C + +NGGC
Sbjct: 619 FWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQ 678
Query: 1028 HLCLLKPGGR------SCACPIGIKLNKDGKTC 1054
+LCL P +CACP G+ L +D ++C
Sbjct: 679 YLCLPAPQINPHSPKFTCACPDGMLLARDMRSC 711
Score = 163 bits (396), Expect = 5e-39
Identities = 135/561 (24%), Positives = 235/561 (41%), Gaps = 56/561 (9%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
++C + E R CH CI+ +++CD D DC D SDE +C V+ N+S I
Sbjct: 107 KTCSQDEFR--CHDGK-CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCI-- 161
Query: 216 VITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKC 275
P + P C + + R + + C+ +F C + +C
Sbjct: 162 ----PQLWACDNDPD--------CEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGEC 209
Query: 276 VPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDE 335
+ ++CDG DC D +DE++C + +C EF+C+DG CI +CD E DC D DE
Sbjct: 210 IHSSWRCDGGPDCKDKSDEENCAV--ATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDE 267
Query: 336 LNCKPNSIRNC-SLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ 394
+ C ++ C +++ C C+ +C+ RDC + DE E C
Sbjct: 268 VGCV--NVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKE---------CGTN 316
Query: 395 EHLMSNAFRNCVNRKHVCDGMKD-----CPRGDD---EERCPLKRKCSAEEKCEKLCITT 446
E L +N C HVC+ +K CP G + RC +C + C +LC+
Sbjct: 317 ECLDNNG--GC---SHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNL 371
Query: 447 YDGHAACACPMGFLLAEDKYSCRDIDECMY----EQDPVCSQTCSNTVGSFRCGCMTGYI 502
G+ C C GF L +C+ + Y + V T + + + +
Sbjct: 372 EGGY-KCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVV 430
Query: 503 LRPDERSCKP---TGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLV 559
E + + S ++ S ++ + D +S + +A+D+ + +
Sbjct: 431 ALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSN--I 488
Query: 560 FWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGT-RRVEVATLD 618
+W+++ L + VA + R P + VD +H ++WTD GT +++ L+
Sbjct: 489 YWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLN 548
Query: 619 GSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPN 678
G LV ++ P I + ++W D I D++G RKT++ DE +
Sbjct: 549 GVDIYSLVTENIQWPNGITLDLLSGRLYWVD-SKLHSISSIDVNGGNRKTILEDEKRLAH 607
Query: 679 GLTIDYTESKIYWADAKHHVI 699
++ E K++W D + I
Sbjct: 608 PFSLAVFEDKVFWTDIINEAI 628
Score = 133 bits (321), Expect = 6e-30
Identities = 61/170 (35%), Positives = 92/170 (54%), Gaps = 15/170 (8%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND--GKCIPE 319
RC +F+C++ KC+ + CDG +C D +DE + +C +G+F C +CIP+
Sbjct: 26 RCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQ 85
Query: 320 RWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMN 379
WRCD + DC +G DE C P + CS DE+ C D +C+ + ++CD RDC +G DE +
Sbjct: 86 FWRCDGQVDCDNGSDEQGCPP---KTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEAS 142
Query: 380 CEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE--ERC 427
C V TC P +++ C+ + CD DC G DE +RC
Sbjct: 143 CPV------LTCGPASFQCNSS--TCIPQLWACDNDPDCEDGSDEWPQRC 184
Score = 108 bits (260), Expect = 2e-22
Identities = 53/145 (36%), Positives = 73/145 (50%), Gaps = 14/145 (9%)
Query: 304 CNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADR--RCVLK 361
C EF+C DGKCI +W CD +C DG DE S+ C +++C R RC+ +
Sbjct: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSV-TCKSGDFSCGGRVNRCIPQ 85
Query: 362 TWLCDGVRDCTNGEDEMNC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPR 420
W CDG DC NG DE C +C +D++ C + C++R+ VCD +DC
Sbjct: 86 FWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGK---------CISRQFVCDSDRDCLD 136
Query: 421 GDDEERCPLKRKCSAEEKC-EKLCI 444
G DE CP+ A +C CI
Sbjct: 137 GSDEASCPVLTCGPASFQCNSSTCI 161
Score = 69.7 bits (163), Expect = 9e-11
Identities = 60/279 (21%), Positives = 114/279 (40%), Gaps = 15/279 (5%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVP 1078
C NNGGCSH+C G C CP G +L + C D I+ ++L+
Sbjct: 318 CLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQ-RRCED--IDECQDPDTCSQLCVNLEGG 374
Query: 1079 YLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADG 1138
Y + S +++T+ + ++++ T + ++I N L
Sbjct: 375 YKCQCEEGFQLDPHTKACKAVGSIAYLFFTN--RHEVRKMTLDRSEYTSLIPN-LRNVVA 431
Query: 1139 IVIDSTGRKIYWTDGGRNSIEVAELDG----RNRKVLVWTGLDSPRAIALHYEYGYMFWS 1194
+ + +IYW+D + I +LD + ++ + +P +A+ + + ++W+
Sbjct: 432 LDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWT 491
Query: 1195 DWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFDGH 1253
D + AD G R+ + P + +D + G +YW D I+ +G
Sbjct: 492 D-SVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGV 550
Query: 1254 D-RRTVLSNVPYPYGIV--IVGQHIYWTDWKTKALHRAD 1289
D V N+ +P GI ++ +YW D K ++ D
Sbjct: 551 DIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSID 589
Score = 40.3 bits (90), Expect = 0.061
Identities = 22/58 (37%), Positives = 33/58 (56%), Gaps = 3/58 (5%)
Query: 1600 TGKNITLIRTNLEMAMEIKAVSAD--RQHGWNPCKESNGGCSHLCLFRGHEYICACPD 1655
+G+ ITL + MA + + S + ++ G N C ++NGGCSH+C Y C CPD
Sbjct: 286 SGECITLDKV-CNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPD 342
>BC014514-1|AAH14514.1| 860|Homo sapiens low density lipoprotein
receptor (familial hypercholesterolemia) protein.
Length = 860
Score = 342 bits (841), Expect = 6e-93
Identities = 202/641 (31%), Positives = 302/641 (47%), Gaps = 76/641 (11%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
CI+ +W+CDG +C D SDE +T L V + + G + +
Sbjct: 39 CISYKWVCDGSAECQDGSDESQ----ETCLSVTCKSGDFSCGGRVNR-----------CI 83
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWT 292
++ + DN ++ Q C++ +F C + KC+ + F CD D DC D +
Sbjct: 84 PQFWRCDGQVDCDNGSD-----EQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGS 138
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDEL--NCK-----PNSIRN 345
DE SCP++ +C F+CN CIP+ W CDN+ DC DG DE C+
Sbjct: 139 DEASCPVL--TCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSP 196
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC--------EVSCEED---------- 387
CS E+ C C+ +W CDG DC + DE NC E C +
Sbjct: 197 CSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCD 256
Query: 388 -QYTCRPQEHLMS----------NAFR----NCVNRKHVCDGMKDCPRGDDE--ERCPLK 430
+Y C+ + N F+ C+ VC+ +DC DE + C
Sbjct: 257 REYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTN 316
Query: 431 RKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQTCSNT 489
C +C G+ C CP GF L + C DIDEC QDP CSQ C N
Sbjct: 317 ECLDNNGGCSHVCNDLKIGYE-CLCPDGFQLVAQR-RCEDIDEC---QDPDTCSQLCVNL 371
Query: 490 VGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVA 549
G ++C C G+ L P ++CK G L F+NR +R++ L Y S++ L N VA
Sbjct: 372 EGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVA 431
Query: 550 LDYHYEKKLVFWSENNLRVIRVAQMN----TKNMSDVIRWGLETPAGVAVDWIHDLLFWT 605
LD ++WS+ + R+I Q++ + VI ++ P G+AVDWIH ++WT
Sbjct: 432 LDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWT 491
Query: 606 DSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDK 665
DS V VA G KR L + KPRAI V P ++WTDWG KI++ ++G
Sbjct: 492 DSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVD 551
Query: 666 RKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKV--TTKGLPHPFAL 723
+++ + I WPNG+T+D ++YW D+K H I +G +R+ + K L HPF+L
Sbjct: 552 IYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSL 611
Query: 724 TLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDI 764
+F+D ++WTD ++I + N+ TG + + L P D+
Sbjct: 612 AVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDM 652
Score = 213 bits (519), Expect = 6e-54
Identities = 117/344 (34%), Positives = 188/344 (54%), Gaps = 26/344 (7%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGPINYLIFAHRVDIRVISLDVPYLIDVV 1084
CS LC+ GG C C G +L+ K C A G I YL F +R ++R ++LD ++
Sbjct: 364 CSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLI 423
Query: 1085 LPLPPLKNALGVDVDHSTGLIYWTDTGQRKI-----QRATRLGTHVETVIGNGLHTADGI 1139
P L+N + +D + ++ IYW+D QR I RA + ++ +TVI + DG+
Sbjct: 424 ---PNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSY-DTVISRDIQAPDGL 479
Query: 1140 VIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTS 1199
+D IYWTD ++ VA+ G RK L PRAI + +G+M+W+DWGT
Sbjct: 480 AVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTP 539
Query: 1200 AKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVL 1259
AKI++ ++G + +V I+WPNG+ +D + GRLYW D+K+ +I S D +G +R+T+L
Sbjct: 540 AKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTIL 599
Query: 1260 SN---VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNL---EGLMDIRAIQ 1313
+ + +P+ + + ++WTD +A+ A++ SD ++ +NL E ++ +
Sbjct: 600 EDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLT 659
Query: 1314 SERVLENAC---GTDNGGCSHLCLRSPL------GYTCACPTGM 1348
R + N C NGGC +LCL +P +TCACP GM
Sbjct: 660 QPRGV-NWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGM 702
Score = 194 bits (474), Expect = 2e-48
Identities = 113/349 (32%), Positives = 182/349 (52%), Gaps = 26/349 (7%)
Query: 1325 DNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPE-EFLIFATRGSITYISL 1383
D CS LC+ GY C C G + T K CK+ +L F R + ++L
Sbjct: 360 DPDTCSQLCVNLEGGYKCQCEEGFQLDPHT-----KACKAVGSIAYLFFTNRHEVRKMTL 414
Query: 1384 ESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTN---MSESKTIISQ 1440
+ E T + ++N +A+D I+++DL +I S + +S T+IS+
Sbjct: 415 DRSEY---TSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISR 471
Query: 1441 KLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLIT-GLTEPRALALFPAKGYL 1499
++ P+GL VDWI +NIYWTD+ + VA G RK L ++PRA+ + P G++
Sbjct: 472 DIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFM 531
Query: 1500 YWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLN 1559
YW+DWG I++ L+G +V ++ +PNG+T+D RLYW D+ I + D+N
Sbjct: 532 YWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVN 591
Query: 1560 GQHRVQLVPDAK---NPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAME 1616
G +R ++ D K +PF + F+D ++WTD ++I A++ TG ++ L+ NL +
Sbjct: 592 GGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPED 651
Query: 1617 IKAV-SADRQHGWNPCKE---SNGGCSHLCL----FRGH--EYICACPD 1655
+ + + G N C+ SNGGC +LCL H ++ CACPD
Sbjct: 652 MVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPD 700
Score = 168 bits (408), Expect = 2e-40
Identities = 103/333 (30%), Positives = 168/333 (50%), Gaps = 46/333 (13%)
Query: 762 MDIHSRSCEETPE-KLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKS 820
+D H+++C+ L + R ++R K +D + + +++ VALD + S
Sbjct: 385 LDPHTKACKAVGSIAYLFFTNRHEVR------KMTLDRSEYTSLIPNLRNVVALDTEVAS 438
Query: 821 NSIFWTDVEKDTINRAYLNGSHQT----TIVDSNLIWPAGLAFDWITDKIYWTDGGTNRI 876
N I+W+D+ + I L+ +H T++ ++ P GLA DWI IYWTD +
Sbjct: 439 NRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTV 498
Query: 877 EVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFG 936
V+ + G R L ++ KPR IVV+P G MYW+DWG I++ ++G + L+
Sbjct: 499 SVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTE 558
Query: 937 QMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN---LPHPFGLDLYGDEV 993
+ WPNG+ LDL+ R+YW D +I +++G R ++E+ L HPF L ++ D+V
Sbjct: 559 NIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKV 618
Query: 994 FWTDWDTQSIQAANKDTGAKRRTLG-----------------------CGK---NNGGCS 1027
FWTD ++I +AN+ TG+ L C + +NGGC
Sbjct: 619 FWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQ 678
Query: 1028 HLCLLKPGGR------SCACPIGIKLNKDGKTC 1054
+LCL P +CACP G+ L +D ++C
Sbjct: 679 YLCLPAPQINPHSPKFTCACPDGMLLARDMRSC 711
Score = 163 bits (396), Expect = 5e-39
Identities = 135/561 (24%), Positives = 235/561 (41%), Gaps = 56/561 (9%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
++C + E R CH CI+ +++CD D DC D SDE +C V+ N+S I
Sbjct: 107 KTCSQDEFR--CHDGK-CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCI-- 161
Query: 216 VITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKC 275
P + P C + + R + + C+ +F C + +C
Sbjct: 162 ----PQLWACDNDPD--------CEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGEC 209
Query: 276 VPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDE 335
+ ++CDG DC D +DE++C + +C EF+C+DG CI +CD E DC D DE
Sbjct: 210 IHSSWRCDGGPDCKDKSDEENCAV--ATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDE 267
Query: 336 LNCKPNSIRNC-SLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ 394
+ C ++ C +++ C C+ +C+ RDC + DE E C
Sbjct: 268 VGCV--NVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKE---------CGTN 316
Query: 395 EHLMSNAFRNCVNRKHVCDGMKD-----CPRGDD---EERCPLKRKCSAEEKCEKLCITT 446
E L +N C HVC+ +K CP G + RC +C + C +LC+
Sbjct: 317 ECLDNNG--GC---SHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNL 371
Query: 447 YDGHAACACPMGFLLAEDKYSCRDIDECMY----EQDPVCSQTCSNTVGSFRCGCMTGYI 502
G+ C C GF L +C+ + Y + V T + + + +
Sbjct: 372 EGGY-KCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVV 430
Query: 503 LRPDERSCKP---TGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLV 559
E + + S ++ S ++ + D +S + +A+D+ + +
Sbjct: 431 ALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSN--I 488
Query: 560 FWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGT-RRVEVATLD 618
+W+++ L + VA + R P + VD +H ++WTD GT +++ L+
Sbjct: 489 YWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLN 548
Query: 619 GSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPN 678
G LV ++ P I + ++W D I D++G RKT++ DE +
Sbjct: 549 GVDIYSLVTENIQWPNGITLDLLSGRLYWVD-SKLHSISSIDVNGGNRKTILEDEKRLAH 607
Query: 679 GLTIDYTESKIYWADAKHHVI 699
++ E K++W D + I
Sbjct: 608 PFSLAVFEDKVFWTDIINEAI 628
Score = 133 bits (321), Expect = 6e-30
Identities = 61/170 (35%), Positives = 92/170 (54%), Gaps = 15/170 (8%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND--GKCIPE 319
RC +F+C++ KC+ + CDG +C D +DE + +C +G+F C +CIP+
Sbjct: 26 RCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQ 85
Query: 320 RWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMN 379
WRCD + DC +G DE C P + CS DE+ C D +C+ + ++CD RDC +G DE +
Sbjct: 86 FWRCDGQVDCDNGSDEQGCPP---KTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEAS 142
Query: 380 CEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE--ERC 427
C V TC P +++ C+ + CD DC G DE +RC
Sbjct: 143 CPV------LTCGPASFQCNSS--TCIPQLWACDNDPDCEDGSDEWPQRC 184
Score = 108 bits (260), Expect = 2e-22
Identities = 53/145 (36%), Positives = 73/145 (50%), Gaps = 14/145 (9%)
Query: 304 CNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADR--RCVLK 361
C EF+C DGKCI +W CD +C DG DE S+ C +++C R RC+ +
Sbjct: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSV-TCKSGDFSCGGRVNRCIPQ 85
Query: 362 TWLCDGVRDCTNGEDEMNC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPR 420
W CDG DC NG DE C +C +D++ C + C++R+ VCD +DC
Sbjct: 86 FWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGK---------CISRQFVCDSDRDCLD 136
Query: 421 GDDEERCPLKRKCSAEEKC-EKLCI 444
G DE CP+ A +C CI
Sbjct: 137 GSDEASCPVLTCGPASFQCNSSTCI 161
Score = 69.7 bits (163), Expect = 9e-11
Identities = 60/279 (21%), Positives = 114/279 (40%), Gaps = 15/279 (5%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVP 1078
C NNGGCSH+C G C CP G +L + C D I+ ++L+
Sbjct: 318 CLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQ-RRCED--IDECQDPDTCSQLCVNLEGG 374
Query: 1079 YLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADG 1138
Y + S +++T+ + ++++ T + ++I N L
Sbjct: 375 YKCQCEEGFQLDPHTKACKAVGSIAYLFFTN--RHEVRKMTLDRSEYTSLIPN-LRNVVA 431
Query: 1139 IVIDSTGRKIYWTDGGRNSIEVAELDG----RNRKVLVWTGLDSPRAIALHYEYGYMFWS 1194
+ + +IYW+D + I +LD + ++ + +P +A+ + + ++W+
Sbjct: 432 LDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWT 491
Query: 1195 DWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFDGH 1253
D + AD G R+ + P + +D + G +YW D I+ +G
Sbjct: 492 D-SVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGV 550
Query: 1254 D-RRTVLSNVPYPYGIV--IVGQHIYWTDWKTKALHRAD 1289
D V N+ +P GI ++ +YW D K ++ D
Sbjct: 551 DIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSID 589
Score = 40.3 bits (90), Expect = 0.061
Identities = 22/58 (37%), Positives = 33/58 (56%), Gaps = 3/58 (5%)
Query: 1600 TGKNITLIRTNLEMAMEIKAVSAD--RQHGWNPCKESNGGCSHLCLFRGHEYICACPD 1655
+G+ ITL + MA + + S + ++ G N C ++NGGCSH+C Y C CPD
Sbjct: 286 SGECITLDKV-CNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPD 342
>AY324609-1|AAP72971.1| 860|Homo sapiens low density lipoprotein
receptor protein.
Length = 860
Score = 342 bits (841), Expect = 6e-93
Identities = 202/641 (31%), Positives = 302/641 (47%), Gaps = 76/641 (11%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
CI+ +W+CDG +C D SDE +T L V + + G + +
Sbjct: 39 CISYKWVCDGSAECQDGSDESQ----ETCLSVTCKSGDFSCGGRVNR-----------CI 83
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWT 292
++ + DN ++ Q C++ +F C + KC+ + F CD D DC D +
Sbjct: 84 PQFWRCDGQVDCDNGSD-----EQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGS 138
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDEL--NCK-----PNSIRN 345
DE SCP++ +C F+CN CIP+ W CDN+ DC DG DE C+
Sbjct: 139 DEASCPVL--TCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSP 196
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC--------EVSCEED---------- 387
CS E+ C C+ +W CDG DC + DE NC E C +
Sbjct: 197 CSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCD 256
Query: 388 -QYTCRPQEHLMS----------NAFR----NCVNRKHVCDGMKDCPRGDDE--ERCPLK 430
+Y C+ + N F+ C+ VC+ +DC DE + C
Sbjct: 257 REYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTN 316
Query: 431 RKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQTCSNT 489
C +C G+ C CP GF L + C DIDEC QDP CSQ C N
Sbjct: 317 ECLDNNGGCSHVCNDLKIGYE-CLCPDGFQLVAQR-RCEDIDEC---QDPDTCSQLCVNL 371
Query: 490 VGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVA 549
G ++C C G+ L P ++CK G L F+NR +R++ L Y S++ L N VA
Sbjct: 372 EGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVA 431
Query: 550 LDYHYEKKLVFWSENNLRVIRVAQMN----TKNMSDVIRWGLETPAGVAVDWIHDLLFWT 605
LD ++WS+ + R+I Q++ + VI ++ P G+AVDWIH ++WT
Sbjct: 432 LDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWT 491
Query: 606 DSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDK 665
DS V VA G KR L + KPRAI V P ++WTDWG KI++ ++G
Sbjct: 492 DSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVD 551
Query: 666 RKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKV--TTKGLPHPFAL 723
+++ + I WPNG+T+D ++YW D+K H I +G +R+ + K L HPF+L
Sbjct: 552 IYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSL 611
Query: 724 TLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDI 764
+F+D ++WTD ++I + N+ TG + + L P D+
Sbjct: 612 AVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDM 652
Score = 213 bits (519), Expect = 6e-54
Identities = 117/344 (34%), Positives = 188/344 (54%), Gaps = 26/344 (7%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGPINYLIFAHRVDIRVISLDVPYLIDVV 1084
CS LC+ GG C C G +L+ K C A G I YL F +R ++R ++LD ++
Sbjct: 364 CSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLI 423
Query: 1085 LPLPPLKNALGVDVDHSTGLIYWTDTGQRKI-----QRATRLGTHVETVIGNGLHTADGI 1139
P L+N + +D + ++ IYW+D QR I RA + ++ +TVI + DG+
Sbjct: 424 ---PNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSY-DTVISRDIQAPDGL 479
Query: 1140 VIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTS 1199
+D IYWTD ++ VA+ G RK L PRAI + +G+M+W+DWGT
Sbjct: 480 AVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTP 539
Query: 1200 AKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVL 1259
AKI++ ++G + +V I+WPNG+ +D + GRLYW D+K+ +I S D +G +R+T+L
Sbjct: 540 AKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTIL 599
Query: 1260 SN---VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNL---EGLMDIRAIQ 1313
+ + +P+ + + ++WTD +A+ A++ SD ++ +NL E ++ +
Sbjct: 600 EDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLT 659
Query: 1314 SERVLENAC---GTDNGGCSHLCLRSPL------GYTCACPTGM 1348
R + N C NGGC +LCL +P +TCACP GM
Sbjct: 660 QPRGV-NWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGM 702
Score = 194 bits (474), Expect = 2e-48
Identities = 113/349 (32%), Positives = 182/349 (52%), Gaps = 26/349 (7%)
Query: 1325 DNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPE-EFLIFATRGSITYISL 1383
D CS LC+ GY C C G + T K CK+ +L F R + ++L
Sbjct: 360 DPDTCSQLCVNLEGGYKCQCEEGFQLDPHT-----KACKAVGSIAYLFFTNRHEVRKMTL 414
Query: 1384 ESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTN---MSESKTIISQ 1440
+ E T + ++N +A+D I+++DL +I S + +S T+IS+
Sbjct: 415 DRSEY---TSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISR 471
Query: 1441 KLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLIT-GLTEPRALALFPAKGYL 1499
++ P+GL VDWI +NIYWTD+ + VA G RK L ++PRA+ + P G++
Sbjct: 472 DIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFM 531
Query: 1500 YWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLN 1559
YW+DWG I++ L+G +V ++ +PNG+T+D RLYW D+ I + D+N
Sbjct: 532 YWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVN 591
Query: 1560 GQHRVQLVPDAK---NPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAME 1616
G +R ++ D K +PF + F+D ++WTD ++I A++ TG ++ L+ NL +
Sbjct: 592 GGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPED 651
Query: 1617 IKAV-SADRQHGWNPCKE---SNGGCSHLCL----FRGH--EYICACPD 1655
+ + + G N C+ SNGGC +LCL H ++ CACPD
Sbjct: 652 MVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPD 700
Score = 168 bits (408), Expect = 2e-40
Identities = 103/333 (30%), Positives = 168/333 (50%), Gaps = 46/333 (13%)
Query: 762 MDIHSRSCEETPE-KLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKS 820
+D H+++C+ L + R ++R K +D + + +++ VALD + S
Sbjct: 385 LDPHTKACKAVGSIAYLFFTNRHEVR------KMTLDRSEYTSLIPNLRNVVALDTEVAS 438
Query: 821 NSIFWTDVEKDTINRAYLNGSHQT----TIVDSNLIWPAGLAFDWITDKIYWTDGGTNRI 876
N I+W+D+ + I L+ +H T++ ++ P GLA DWI IYWTD +
Sbjct: 439 NRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTV 498
Query: 877 EVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFG 936
V+ + G R L ++ KPR IVV+P G MYW+DWG I++ ++G + L+
Sbjct: 499 SVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTE 558
Query: 937 QMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN---LPHPFGLDLYGDEV 993
+ WPNG+ LDL+ R+YW D +I +++G R ++E+ L HPF L ++ D+V
Sbjct: 559 NIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKV 618
Query: 994 FWTDWDTQSIQAANKDTGAKRRTLG-----------------------CGK---NNGGCS 1027
FWTD ++I +AN+ TG+ L C + +NGGC
Sbjct: 619 FWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQ 678
Query: 1028 HLCLLKPGGR------SCACPIGIKLNKDGKTC 1054
+LCL P +CACP G+ L +D ++C
Sbjct: 679 YLCLPAPQINPHSPKFTCACPDGMLLARDMRSC 711
Score = 163 bits (396), Expect = 5e-39
Identities = 135/561 (24%), Positives = 235/561 (41%), Gaps = 56/561 (9%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
++C + E R CH CI+ +++CD D DC D SDE +C V+ N+S I
Sbjct: 107 KTCSQDEFR--CHDGK-CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCI-- 161
Query: 216 VITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKC 275
P + P C + + R + + C+ +F C + +C
Sbjct: 162 ----PQLWACDNDPD--------CEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGEC 209
Query: 276 VPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDE 335
+ ++CDG DC D +DE++C + +C EF+C+DG CI +CD E DC D DE
Sbjct: 210 IHSSWRCDGGPDCKDKSDEENCAV--ATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDE 267
Query: 336 LNCKPNSIRNC-SLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ 394
+ C ++ C +++ C C+ +C+ RDC + DE E C
Sbjct: 268 VGCV--NVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKE---------CGTN 316
Query: 395 EHLMSNAFRNCVNRKHVCDGMKD-----CPRGDD---EERCPLKRKCSAEEKCEKLCITT 446
E L +N C HVC+ +K CP G + RC +C + C +LC+
Sbjct: 317 ECLDNNG--GC---SHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNL 371
Query: 447 YDGHAACACPMGFLLAEDKYSCRDIDECMY----EQDPVCSQTCSNTVGSFRCGCMTGYI 502
G+ C C GF L +C+ + Y + V T + + + +
Sbjct: 372 EGGY-KCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVV 430
Query: 503 LRPDERSCKP---TGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLV 559
E + + S ++ S ++ + D +S + +A+D+ + +
Sbjct: 431 ALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSN--I 488
Query: 560 FWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGT-RRVEVATLD 618
+W+++ L + VA + R P + VD +H ++WTD GT +++ L+
Sbjct: 489 YWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLN 548
Query: 619 GSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPN 678
G LV ++ P I + ++W D I D++G RKT++ DE +
Sbjct: 549 GVDIYSLVTENIQWPNGITLDLLSGRLYWVD-SKLHSISSIDVNGGNRKTILEDEKRLAH 607
Query: 679 GLTIDYTESKIYWADAKHHVI 699
++ E K++W D + I
Sbjct: 608 PFSLAVFEDKVFWTDIINEAI 628
Score = 133 bits (321), Expect = 6e-30
Identities = 61/170 (35%), Positives = 92/170 (54%), Gaps = 15/170 (8%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND--GKCIPE 319
RC +F+C++ KC+ + CDG +C D +DE + +C +G+F C +CIP+
Sbjct: 26 RCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQ 85
Query: 320 RWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMN 379
WRCD + DC +G DE C P + CS DE+ C D +C+ + ++CD RDC +G DE +
Sbjct: 86 FWRCDGQVDCDNGSDEQGCPP---KTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEAS 142
Query: 380 CEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE--ERC 427
C V TC P +++ C+ + CD DC G DE +RC
Sbjct: 143 CPV------LTCGPASFQCNSS--TCIPQLWACDNDPDCEDGSDEWPQRC 184
Score = 108 bits (260), Expect = 2e-22
Identities = 53/145 (36%), Positives = 73/145 (50%), Gaps = 14/145 (9%)
Query: 304 CNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADR--RCVLK 361
C EF+C DGKCI +W CD +C DG DE S+ C +++C R RC+ +
Sbjct: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSV-TCKSGDFSCGGRVNRCIPQ 85
Query: 362 TWLCDGVRDCTNGEDEMNC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPR 420
W CDG DC NG DE C +C +D++ C + C++R+ VCD +DC
Sbjct: 86 FWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGK---------CISRQFVCDSDRDCLD 136
Query: 421 GDDEERCPLKRKCSAEEKC-EKLCI 444
G DE CP+ A +C CI
Sbjct: 137 GSDEASCPVLTCGPASFQCNSSTCI 161
Score = 69.7 bits (163), Expect = 9e-11
Identities = 60/279 (21%), Positives = 114/279 (40%), Gaps = 15/279 (5%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVP 1078
C NNGGCSH+C G C CP G +L + C D I+ ++L+
Sbjct: 318 CLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQ-RRCED--IDECQDPDTCSQLCVNLEGG 374
Query: 1079 YLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADG 1138
Y + S +++T+ + ++++ T + ++I N L
Sbjct: 375 YKCQCEEGFQLDPHTKACKAVGSIAYLFFTN--RHEVRKMTLDRSEYTSLIPN-LRNVVA 431
Query: 1139 IVIDSTGRKIYWTDGGRNSIEVAELDG----RNRKVLVWTGLDSPRAIALHYEYGYMFWS 1194
+ + +IYW+D + I +LD + ++ + +P +A+ + + ++W+
Sbjct: 432 LDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWT 491
Query: 1195 DWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFDGH 1253
D + AD G R+ + P + +D + G +YW D I+ +G
Sbjct: 492 D-SVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGV 550
Query: 1254 D-RRTVLSNVPYPYGIV--IVGQHIYWTDWKTKALHRAD 1289
D V N+ +P GI ++ +YW D K ++ D
Sbjct: 551 DIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSID 589
Score = 40.3 bits (90), Expect = 0.061
Identities = 22/58 (37%), Positives = 33/58 (56%), Gaps = 3/58 (5%)
Query: 1600 TGKNITLIRTNLEMAMEIKAVSAD--RQHGWNPCKESNGGCSHLCLFRGHEYICACPD 1655
+G+ ITL + MA + + S + ++ G N C ++NGGCSH+C Y C CPD
Sbjct: 286 SGECITLDKV-CNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPD 342
>AY114155-1|AAM56036.1| 860|Homo sapiens low density lipoprotein
receptor protein.
Length = 860
Score = 342 bits (841), Expect = 6e-93
Identities = 202/641 (31%), Positives = 302/641 (47%), Gaps = 76/641 (11%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
CI+ +W+CDG +C D SDE +T L V + + G + +
Sbjct: 39 CISYKWVCDGSAECQDGSDESQ----ETCLSVTCKSGDFSCGGRVNR-----------CI 83
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWT 292
++ + DN ++ Q C++ +F C + KC+ + F CD D DC D +
Sbjct: 84 PQFWRCDGQVDCDNGSD-----EQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGS 138
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDEL--NCK-----PNSIRN 345
DE SCP++ +C F+CN CIP+ W CDN+ DC DG DE C+
Sbjct: 139 DEASCPVL--TCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSP 196
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC--------EVSCEED---------- 387
CS E+ C C+ +W CDG DC + DE NC E C +
Sbjct: 197 CSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCD 256
Query: 388 -QYTCRPQEHLMS----------NAFR----NCVNRKHVCDGMKDCPRGDDE--ERCPLK 430
+Y C+ + N F+ C+ VC+ +DC DE + C
Sbjct: 257 REYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTN 316
Query: 431 RKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQTCSNT 489
C +C G+ C CP GF L + C DIDEC QDP CSQ C N
Sbjct: 317 ECLDNNGGCSHVCNDLKIGYE-CLCPDGFQLVAQR-RCEDIDEC---QDPDTCSQLCVNL 371
Query: 490 VGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVA 549
G ++C C G+ L P ++CK G L F+NR +R++ L Y S++ L N VA
Sbjct: 372 EGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVA 431
Query: 550 LDYHYEKKLVFWSENNLRVIRVAQMN----TKNMSDVIRWGLETPAGVAVDWIHDLLFWT 605
LD ++WS+ + R+I Q++ + VI ++ P G+AVDWIH ++WT
Sbjct: 432 LDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWT 491
Query: 606 DSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDK 665
DS V VA G KR L + KPRAI V P ++WTDWG KI++ ++G
Sbjct: 492 DSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVD 551
Query: 666 RKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKV--TTKGLPHPFAL 723
+++ + I WPNG+T+D ++YW D+K H I +G +R+ + K L HPF+L
Sbjct: 552 IYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSL 611
Query: 724 TLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDI 764
+F+D ++WTD ++I + N+ TG + + L P D+
Sbjct: 612 AVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDM 652
Score = 213 bits (519), Expect = 6e-54
Identities = 117/344 (34%), Positives = 188/344 (54%), Gaps = 26/344 (7%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGPINYLIFAHRVDIRVISLDVPYLIDVV 1084
CS LC+ GG C C G +L+ K C A G I YL F +R ++R ++LD ++
Sbjct: 364 CSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLI 423
Query: 1085 LPLPPLKNALGVDVDHSTGLIYWTDTGQRKI-----QRATRLGTHVETVIGNGLHTADGI 1139
P L+N + +D + ++ IYW+D QR I RA + ++ +TVI + DG+
Sbjct: 424 ---PNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSY-DTVISRDIQAPDGL 479
Query: 1140 VIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTS 1199
+D IYWTD ++ VA+ G RK L PRAI + +G+M+W+DWGT
Sbjct: 480 AVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTP 539
Query: 1200 AKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVL 1259
AKI++ ++G + +V I+WPNG+ +D + GRLYW D+K+ +I S D +G +R+T+L
Sbjct: 540 AKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTIL 599
Query: 1260 SN---VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNL---EGLMDIRAIQ 1313
+ + +P+ + + ++WTD +A+ A++ SD ++ +NL E ++ +
Sbjct: 600 EDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLT 659
Query: 1314 SERVLENAC---GTDNGGCSHLCLRSPL------GYTCACPTGM 1348
R + N C NGGC +LCL +P +TCACP GM
Sbjct: 660 QPRGV-NWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGM 702
Score = 194 bits (474), Expect = 2e-48
Identities = 113/349 (32%), Positives = 182/349 (52%), Gaps = 26/349 (7%)
Query: 1325 DNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPE-EFLIFATRGSITYISL 1383
D CS LC+ GY C C G + T K CK+ +L F R + ++L
Sbjct: 360 DPDTCSQLCVNLEGGYKCQCEEGFQLDPHT-----KACKAVGSIAYLFFTNRHEVRKMTL 414
Query: 1384 ESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTN---MSESKTIISQ 1440
+ E T + ++N +A+D I+++DL +I S + +S T+IS+
Sbjct: 415 DRSEY---TSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISR 471
Query: 1441 KLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLIT-GLTEPRALALFPAKGYL 1499
++ P+GL VDWI +NIYWTD+ + VA G RK L ++PRA+ + P G++
Sbjct: 472 DIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFM 531
Query: 1500 YWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLN 1559
YW+DWG I++ L+G +V ++ +PNG+T+D RLYW D+ I + D+N
Sbjct: 532 YWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVN 591
Query: 1560 GQHRVQLVPDAK---NPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAME 1616
G +R ++ D K +PF + F+D ++WTD ++I A++ TG ++ L+ NL +
Sbjct: 592 GGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPED 651
Query: 1617 IKAV-SADRQHGWNPCKE---SNGGCSHLCL----FRGH--EYICACPD 1655
+ + + G N C+ SNGGC +LCL H ++ CACPD
Sbjct: 652 MVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPD 700
Score = 168 bits (408), Expect = 2e-40
Identities = 103/333 (30%), Positives = 168/333 (50%), Gaps = 46/333 (13%)
Query: 762 MDIHSRSCEETPE-KLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKS 820
+D H+++C+ L + R ++R K +D + + +++ VALD + S
Sbjct: 385 LDPHTKACKAVGSIAYLFFTNRHEVR------KMTLDRSEYTSLIPNLRNVVALDTEVAS 438
Query: 821 NSIFWTDVEKDTINRAYLNGSHQT----TIVDSNLIWPAGLAFDWITDKIYWTDGGTNRI 876
N I+W+D+ + I L+ +H T++ ++ P GLA DWI IYWTD +
Sbjct: 439 NRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTV 498
Query: 877 EVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFG 936
V+ + G R L ++ KPR IVV+P G MYW+DWG I++ ++G + L+
Sbjct: 499 SVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTE 558
Query: 937 QMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN---LPHPFGLDLYGDEV 993
+ WPNG+ LDL+ R+YW D +I +++G R ++E+ L HPF L ++ D+V
Sbjct: 559 NIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKV 618
Query: 994 FWTDWDTQSIQAANKDTGAKRRTLG-----------------------CGK---NNGGCS 1027
FWTD ++I +AN+ TG+ L C + +NGGC
Sbjct: 619 FWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQ 678
Query: 1028 HLCLLKPGGR------SCACPIGIKLNKDGKTC 1054
+LCL P +CACP G+ L +D ++C
Sbjct: 679 YLCLPAPQINPHSPKFTCACPDGMLLARDMRSC 711
Score = 163 bits (396), Expect = 5e-39
Identities = 135/561 (24%), Positives = 235/561 (41%), Gaps = 56/561 (9%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
++C + E R CH CI+ +++CD D DC D SDE +C V+ N+S I
Sbjct: 107 KTCSQDEFR--CHDGK-CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCI-- 161
Query: 216 VITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKC 275
P + P C + + R + + C+ +F C + +C
Sbjct: 162 ----PQLWACDNDPD--------CEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGEC 209
Query: 276 VPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDE 335
+ ++CDG DC D +DE++C + +C EF+C+DG CI +CD E DC D DE
Sbjct: 210 IHSSWRCDGGPDCKDKSDEENCAV--ATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDE 267
Query: 336 LNCKPNSIRNC-SLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ 394
+ C ++ C +++ C C+ +C+ RDC + DE E C
Sbjct: 268 VGCV--NVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKE---------CGTN 316
Query: 395 EHLMSNAFRNCVNRKHVCDGMKD-----CPRGDD---EERCPLKRKCSAEEKCEKLCITT 446
E L +N C HVC+ +K CP G + RC +C + C +LC+
Sbjct: 317 ECLDNNG--GC---SHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNL 371
Query: 447 YDGHAACACPMGFLLAEDKYSCRDIDECMY----EQDPVCSQTCSNTVGSFRCGCMTGYI 502
G+ C C GF L +C+ + Y + V T + + + +
Sbjct: 372 EGGY-KCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVV 430
Query: 503 LRPDERSCKP---TGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLV 559
E + + S ++ S ++ + D +S + +A+D+ + +
Sbjct: 431 ALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSN--I 488
Query: 560 FWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGT-RRVEVATLD 618
+W+++ L + VA + R P + VD +H ++WTD GT +++ L+
Sbjct: 489 YWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLN 548
Query: 619 GSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPN 678
G LV ++ P I + ++W D I D++G RKT++ DE +
Sbjct: 549 GVDIYSLVTENIQWPNGITLDLLSGRLYWVD-SKLHSISSIDVNGGNRKTILEDEKRLAH 607
Query: 679 GLTIDYTESKIYWADAKHHVI 699
++ E K++W D + I
Sbjct: 608 PFSLAVFEDKVFWTDIINEAI 628
Score = 133 bits (321), Expect = 6e-30
Identities = 61/170 (35%), Positives = 92/170 (54%), Gaps = 15/170 (8%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND--GKCIPE 319
RC +F+C++ KC+ + CDG +C D +DE + +C +G+F C +CIP+
Sbjct: 26 RCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQ 85
Query: 320 RWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMN 379
WRCD + DC +G DE C P + CS DE+ C D +C+ + ++CD RDC +G DE +
Sbjct: 86 FWRCDGQVDCDNGSDEQGCPP---KTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEAS 142
Query: 380 CEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE--ERC 427
C V TC P +++ C+ + CD DC G DE +RC
Sbjct: 143 CPV------LTCGPASFQCNSS--TCIPQLWACDNDPDCEDGSDEWPQRC 184
Score = 108 bits (260), Expect = 2e-22
Identities = 53/145 (36%), Positives = 73/145 (50%), Gaps = 14/145 (9%)
Query: 304 CNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADR--RCVLK 361
C EF+C DGKCI +W CD +C DG DE S+ C +++C R RC+ +
Sbjct: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSV-TCKSGDFSCGGRVNRCIPQ 85
Query: 362 TWLCDGVRDCTNGEDEMNC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPR 420
W CDG DC NG DE C +C +D++ C + C++R+ VCD +DC
Sbjct: 86 FWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGK---------CISRQFVCDSDRDCLD 136
Query: 421 GDDEERCPLKRKCSAEEKC-EKLCI 444
G DE CP+ A +C CI
Sbjct: 137 GSDEASCPVLTCGPASFQCNSSTCI 161
Score = 69.7 bits (163), Expect = 9e-11
Identities = 60/279 (21%), Positives = 114/279 (40%), Gaps = 15/279 (5%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVP 1078
C NNGGCSH+C G C CP G +L + C D I+ ++L+
Sbjct: 318 CLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQ-RRCED--IDECQDPDTCSQLCVNLEGG 374
Query: 1079 YLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADG 1138
Y + S +++T+ + ++++ T + ++I N L
Sbjct: 375 YKCQCEEGFQLDPHTKACKAVGSIAYLFFTN--RHEVRKMTLDRSEYTSLIPN-LRNVVA 431
Query: 1139 IVIDSTGRKIYWTDGGRNSIEVAELDG----RNRKVLVWTGLDSPRAIALHYEYGYMFWS 1194
+ + +IYW+D + I +LD + ++ + +P +A+ + + ++W+
Sbjct: 432 LDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWT 491
Query: 1195 DWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFDGH 1253
D + AD G R+ + P + +D + G +YW D I+ +G
Sbjct: 492 D-SVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGV 550
Query: 1254 D-RRTVLSNVPYPYGIV--IVGQHIYWTDWKTKALHRAD 1289
D V N+ +P GI ++ +YW D K ++ D
Sbjct: 551 DIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSID 589
Score = 40.3 bits (90), Expect = 0.061
Identities = 22/58 (37%), Positives = 33/58 (56%), Gaps = 3/58 (5%)
Query: 1600 TGKNITLIRTNLEMAMEIKAVSAD--RQHGWNPCKESNGGCSHLCLFRGHEYICACPD 1655
+G+ ITL + MA + + S + ++ G N C ++NGGCSH+C Y C CPD
Sbjct: 286 SGECITLDKV-CNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPD 342
>AF217403-1|AAF24515.1| 837|Homo sapiens low density lipoprotein
receptor protein.
Length = 837
Score = 342 bits (841), Expect = 6e-93
Identities = 202/641 (31%), Positives = 302/641 (47%), Gaps = 76/641 (11%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
CI+ +W+CDG +C D SDE +T L V + + G + +
Sbjct: 16 CISYKWVCDGSAECQDGSDESQ----ETCLSVTCKSGDFSCGGRVNR-----------CI 60
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWT 292
++ + DN ++ Q C++ +F C + KC+ + F CD D DC D +
Sbjct: 61 PQFWRCDGQVDCDNGSD-----EQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGS 115
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDEL--NCK-----PNSIRN 345
DE SCP++ +C F+CN CIP+ W CDN+ DC DG DE C+
Sbjct: 116 DEASCPVL--TCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSP 173
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC--------EVSCEED---------- 387
CS E+ C C+ +W CDG DC + DE NC E C +
Sbjct: 174 CSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCD 233
Query: 388 -QYTCRPQEHLMS----------NAFR----NCVNRKHVCDGMKDCPRGDDE--ERCPLK 430
+Y C+ + N F+ C+ VC+ +DC DE + C
Sbjct: 234 REYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTN 293
Query: 431 RKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQTCSNT 489
C +C G+ C CP GF L + C DIDEC QDP CSQ C N
Sbjct: 294 ECLDNNGGCSHVCNDLKIGYE-CLCPDGFQLVAQR-RCEDIDEC---QDPDTCSQLCVNL 348
Query: 490 VGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVA 549
G ++C C G+ L P ++CK G L F+NR +R++ L Y S++ L N VA
Sbjct: 349 EGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVA 408
Query: 550 LDYHYEKKLVFWSENNLRVIRVAQMN----TKNMSDVIRWGLETPAGVAVDWIHDLLFWT 605
LD ++WS+ + R+I Q++ + VI ++ P G+AVDWIH ++WT
Sbjct: 409 LDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWT 468
Query: 606 DSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDK 665
DS V VA G KR L + KPRAI V P ++WTDWG KI++ ++G
Sbjct: 469 DSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVD 528
Query: 666 RKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKV--TTKGLPHPFAL 723
+++ + I WPNG+T+D ++YW D+K H I +G +R+ + K L HPF+L
Sbjct: 529 IYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSL 588
Query: 724 TLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDI 764
+F+D ++WTD ++I + N+ TG + + L P D+
Sbjct: 589 AVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDM 629
Score = 210 bits (513), Expect = 3e-53
Identities = 118/345 (34%), Positives = 188/345 (54%), Gaps = 28/345 (8%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGPINYLIFAHRVDIRVISLDVPYLIDVV 1084
CS LC+ GG C C G +L+ K C A G I YL F +R ++R ++LD ++
Sbjct: 341 CSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLI 400
Query: 1085 LPLPPLKNALGVDVDHSTGLIYWTDTGQRKI-----QRATRLGTHVETVIGNGLHTADGI 1139
P L+N + +D + ++ IYW+D QR I RA + ++ +TVI + DG+
Sbjct: 401 ---PNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSY-DTVISRDIQAPDGL 456
Query: 1140 VIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTS 1199
+D IYWTD ++ VA+ G RK L PRAI + +G+M+W+DWGT
Sbjct: 457 AVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTP 516
Query: 1200 AKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVL 1259
AKI++ ++G + +V I+WPNG+ +D + GRLYW D+K+ +I S D +G +R+T+L
Sbjct: 517 AKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTIL 576
Query: 1260 SN---VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNL---EGLMDIRAIQ 1313
+ + +P+ + + ++WTD +A+ A++ SD ++ +NL E ++ +
Sbjct: 577 EDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLT 636
Query: 1314 SERVLENAC---GTDNGGCSHLCL-------RSPLGYTCACPTGM 1348
R + N C NGGC +LCL SP +TCACP GM
Sbjct: 637 QPRGV-NWCERTTLSNGGCQYLCLPASQINPHSP-KFTCACPDGM 679
Score = 194 bits (474), Expect = 2e-48
Identities = 113/349 (32%), Positives = 182/349 (52%), Gaps = 26/349 (7%)
Query: 1325 DNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPE-EFLIFATRGSITYISL 1383
D CS LC+ GY C C G + T K CK+ +L F R + ++L
Sbjct: 337 DPDTCSQLCVNLEGGYKCQCEEGFQLDPHT-----KACKAVGSIAYLFFTNRHEVRKMTL 391
Query: 1384 ESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTN---MSESKTIISQ 1440
+ E T + ++N +A+D I+++DL +I S + +S T+IS+
Sbjct: 392 DRSEY---TSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISR 448
Query: 1441 KLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLIT-GLTEPRALALFPAKGYL 1499
++ P+GL VDWI +NIYWTD+ + VA G RK L ++PRA+ + P G++
Sbjct: 449 DIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFM 508
Query: 1500 YWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLN 1559
YW+DWG I++ L+G +V ++ +PNG+T+D RLYW D+ I + D+N
Sbjct: 509 YWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVN 568
Query: 1560 GQHRVQLVPDAK---NPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAME 1616
G +R ++ D K +PF + F+D ++WTD ++I A++ TG ++ L+ NL +
Sbjct: 569 GGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPED 628
Query: 1617 IKAV-SADRQHGWNPCKE---SNGGCSHLCL----FRGH--EYICACPD 1655
+ + + G N C+ SNGGC +LCL H ++ CACPD
Sbjct: 629 MVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPASQINPHSPKFTCACPD 677
Score = 167 bits (407), Expect = 2e-40
Identities = 103/333 (30%), Positives = 169/333 (50%), Gaps = 46/333 (13%)
Query: 762 MDIHSRSCEETPE-KLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKS 820
+D H+++C+ L + R ++R K +D + + +++ VALD + S
Sbjct: 362 LDPHTKACKAVGSIAYLFFTNRHEVR------KMTLDRSEYTSLIPNLRNVVALDTEVAS 415
Query: 821 NSIFWTDVEKDTINRAYLNGSHQT----TIVDSNLIWPAGLAFDWITDKIYWTDGGTNRI 876
N I+W+D+ + I L+ +H T++ ++ P GLA DWI IYWTD +
Sbjct: 416 NRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTV 475
Query: 877 EVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFG 936
V+ + G R L ++ KPR IVV+P G MYW+DWG I++ ++G + L+
Sbjct: 476 SVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTE 535
Query: 937 QMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN---LPHPFGLDLYGDEV 993
+ WPNG+ LDL+ R+YW D +I +++G R ++E+ L HPF L ++ D+V
Sbjct: 536 NIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKV 595
Query: 994 FWTDWDTQSIQAANKDTGAKRRTLG-----------------------CGK---NNGGCS 1027
FWTD ++I +AN+ TG+ L C + +NGGC
Sbjct: 596 FWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQ 655
Query: 1028 HLCL----LKPGGR--SCACPIGIKLNKDGKTC 1054
+LCL + P +CACP G+ L +D ++C
Sbjct: 656 YLCLPASQINPHSPKFTCACPDGMLLARDMRSC 688
Score = 163 bits (396), Expect = 5e-39
Identities = 135/561 (24%), Positives = 235/561 (41%), Gaps = 56/561 (9%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
++C + E R CH CI+ +++CD D DC D SDE +C V+ N+S I
Sbjct: 84 KTCSQDEFR--CHDGK-CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCI-- 138
Query: 216 VITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKC 275
P + P C + + R + + C+ +F C + +C
Sbjct: 139 ----PQLWACDNDPD--------CEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGEC 186
Query: 276 VPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDE 335
+ ++CDG DC D +DE++C + +C EF+C+DG CI +CD E DC D DE
Sbjct: 187 IHSSWRCDGGPDCKDKSDEENCAV--ATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDE 244
Query: 336 LNCKPNSIRNC-SLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ 394
+ C ++ C +++ C C+ +C+ RDC + DE E C
Sbjct: 245 VGCV--NVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKE---------CGTN 293
Query: 395 EHLMSNAFRNCVNRKHVCDGMKD-----CPRGDD---EERCPLKRKCSAEEKCEKLCITT 446
E L +N C HVC+ +K CP G + RC +C + C +LC+
Sbjct: 294 ECLDNNG--GC---SHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNL 348
Query: 447 YDGHAACACPMGFLLAEDKYSCRDIDECMY----EQDPVCSQTCSNTVGSFRCGCMTGYI 502
G+ C C GF L +C+ + Y + V T + + + +
Sbjct: 349 EGGY-KCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVV 407
Query: 503 LRPDERSCKP---TGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLV 559
E + + S ++ S ++ + D +S + +A+D+ + +
Sbjct: 408 ALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSN--I 465
Query: 560 FWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGT-RRVEVATLD 618
+W+++ L + VA + R P + VD +H ++WTD GT +++ L+
Sbjct: 466 YWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLN 525
Query: 619 GSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPN 678
G LV ++ P I + ++W D I D++G RKT++ DE +
Sbjct: 526 GVDIYSLVTENIQWPNGITLDLLSGRLYWVD-SKLHSISSIDVNGGNRKTILEDEKRLAH 584
Query: 679 GLTIDYTESKIYWADAKHHVI 699
++ E K++W D + I
Sbjct: 585 PFSLAVFEDKVFWTDIINEAI 605
Score = 133 bits (321), Expect = 6e-30
Identities = 61/170 (35%), Positives = 92/170 (54%), Gaps = 15/170 (8%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND--GKCIPE 319
RC +F+C++ KC+ + CDG +C D +DE + +C +G+F C +CIP+
Sbjct: 3 RCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQ 62
Query: 320 RWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMN 379
WRCD + DC +G DE C P + CS DE+ C D +C+ + ++CD RDC +G DE +
Sbjct: 63 FWRCDGQVDCDNGSDEQGCPP---KTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEAS 119
Query: 380 CEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE--ERC 427
C V TC P +++ C+ + CD DC G DE +RC
Sbjct: 120 CPV------LTCGPASFQCNSS--TCIPQLWACDNDPDCEDGSDEWPQRC 161
Score = 108 bits (260), Expect = 2e-22
Identities = 53/145 (36%), Positives = 73/145 (50%), Gaps = 14/145 (9%)
Query: 304 CNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADR--RCVLK 361
C EF+C DGKCI +W CD +C DG DE S+ C +++C R RC+ +
Sbjct: 4 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSV-TCKSGDFSCGGRVNRCIPQ 62
Query: 362 TWLCDGVRDCTNGEDEMNC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPR 420
W CDG DC NG DE C +C +D++ C + C++R+ VCD +DC
Sbjct: 63 FWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGK---------CISRQFVCDSDRDCLD 113
Query: 421 GDDEERCPLKRKCSAEEKC-EKLCI 444
G DE CP+ A +C CI
Sbjct: 114 GSDEASCPVLTCGPASFQCNSSTCI 138
Score = 69.7 bits (163), Expect = 9e-11
Identities = 60/279 (21%), Positives = 114/279 (40%), Gaps = 15/279 (5%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVP 1078
C NNGGCSH+C G C CP G +L + C D I+ ++L+
Sbjct: 295 CLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQ-RRCED--IDECQDPDTCSQLCVNLEGG 351
Query: 1079 YLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADG 1138
Y + S +++T+ + ++++ T + ++I N L
Sbjct: 352 YKCQCEEGFQLDPHTKACKAVGSIAYLFFTN--RHEVRKMTLDRSEYTSLIPN-LRNVVA 408
Query: 1139 IVIDSTGRKIYWTDGGRNSIEVAELDG----RNRKVLVWTGLDSPRAIALHYEYGYMFWS 1194
+ + +IYW+D + I +LD + ++ + +P +A+ + + ++W+
Sbjct: 409 LDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWT 468
Query: 1195 DWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFDGH 1253
D + AD G R+ + P + +D + G +YW D I+ +G
Sbjct: 469 D-SVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGV 527
Query: 1254 D-RRTVLSNVPYPYGIV--IVGQHIYWTDWKTKALHRAD 1289
D V N+ +P GI ++ +YW D K ++ D
Sbjct: 528 DIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSID 566
Score = 40.3 bits (90), Expect = 0.061
Identities = 22/58 (37%), Positives = 33/58 (56%), Gaps = 3/58 (5%)
Query: 1600 TGKNITLIRTNLEMAMEIKAVSAD--RQHGWNPCKESNGGCSHLCLFRGHEYICACPD 1655
+G+ ITL + MA + + S + ++ G N C ++NGGCSH+C Y C CPD
Sbjct: 263 SGECITLDKV-CNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPD 319
>AB209409-1|BAD92646.1| 870|Homo sapiens low density lipoprotein
receptor precursor variant protein.
Length = 870
Score = 342 bits (841), Expect = 6e-93
Identities = 202/641 (31%), Positives = 302/641 (47%), Gaps = 76/641 (11%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
CI+ +W+CDG +C D SDE +T L V + + G + +
Sbjct: 51 CISYKWVCDGSAECQDGSDESQ----ETCLSVTCKSGDFSCGGRVNR-----------CI 95
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWT 292
++ + DN ++ Q C++ +F C + KC+ + F CD D DC D +
Sbjct: 96 PQFWRCDGQVDCDNGSD-----EQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGS 150
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDEL--NCK-----PNSIRN 345
DE SCP++ +C F+CN CIP+ W CDN+ DC DG DE C+
Sbjct: 151 DEASCPVL--TCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSP 208
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC--------EVSCEED---------- 387
CS E+ C C+ +W CDG DC + DE NC E C +
Sbjct: 209 CSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCD 268
Query: 388 -QYTCRPQEHLMS----------NAFR----NCVNRKHVCDGMKDCPRGDDE--ERCPLK 430
+Y C+ + N F+ C+ VC+ +DC DE + C
Sbjct: 269 REYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTN 328
Query: 431 RKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQTCSNT 489
C +C G+ C CP GF L + C DIDEC QDP CSQ C N
Sbjct: 329 ECLDNNGGCSHVCNDLKIGYE-CLCPDGFQLVAQR-RCEDIDEC---QDPDTCSQLCVNL 383
Query: 490 VGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVA 549
G ++C C G+ L P ++CK G L F+NR +R++ L Y S++ L N VA
Sbjct: 384 EGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVA 443
Query: 550 LDYHYEKKLVFWSENNLRVIRVAQMN----TKNMSDVIRWGLETPAGVAVDWIHDLLFWT 605
LD ++WS+ + R+I Q++ + VI ++ P G+AVDWIH ++WT
Sbjct: 444 LDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWT 503
Query: 606 DSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDK 665
DS V VA G KR L + KPRAI V P ++WTDWG KI++ ++G
Sbjct: 504 DSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVD 563
Query: 666 RKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKV--TTKGLPHPFAL 723
+++ + I WPNG+T+D ++YW D+K H I +G +R+ + K L HPF+L
Sbjct: 564 IYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSL 623
Query: 724 TLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPMDI 764
+F+D ++WTD ++I + N+ TG + + L P D+
Sbjct: 624 AVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDM 664
Score = 213 bits (519), Expect = 6e-54
Identities = 117/344 (34%), Positives = 188/344 (54%), Gaps = 26/344 (7%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGPINYLIFAHRVDIRVISLDVPYLIDVV 1084
CS LC+ GG C C G +L+ K C A G I YL F +R ++R ++LD ++
Sbjct: 376 CSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLI 435
Query: 1085 LPLPPLKNALGVDVDHSTGLIYWTDTGQRKI-----QRATRLGTHVETVIGNGLHTADGI 1139
P L+N + +D + ++ IYW+D QR I RA + ++ +TVI + DG+
Sbjct: 436 ---PNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSY-DTVISRDIQAPDGL 491
Query: 1140 VIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTS 1199
+D IYWTD ++ VA+ G RK L PRAI + +G+M+W+DWGT
Sbjct: 492 AVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTP 551
Query: 1200 AKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVL 1259
AKI++ ++G + +V I+WPNG+ +D + GRLYW D+K+ +I S D +G +R+T+L
Sbjct: 552 AKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTIL 611
Query: 1260 SN---VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNL---EGLMDIRAIQ 1313
+ + +P+ + + ++WTD +A+ A++ SD ++ +NL E ++ +
Sbjct: 612 EDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLT 671
Query: 1314 SERVLENAC---GTDNGGCSHLCLRSPL------GYTCACPTGM 1348
R + N C NGGC +LCL +P +TCACP GM
Sbjct: 672 QPRGV-NWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGM 714
Score = 194 bits (474), Expect = 2e-48
Identities = 113/349 (32%), Positives = 182/349 (52%), Gaps = 26/349 (7%)
Query: 1325 DNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPE-EFLIFATRGSITYISL 1383
D CS LC+ GY C C G + T K CK+ +L F R + ++L
Sbjct: 372 DPDTCSQLCVNLEGGYKCQCEEGFQLDPHT-----KACKAVGSIAYLFFTNRHEVRKMTL 426
Query: 1384 ESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTN---MSESKTIISQ 1440
+ E T + ++N +A+D I+++DL +I S + +S T+IS+
Sbjct: 427 DRSEY---TSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISR 483
Query: 1441 KLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLIT-GLTEPRALALFPAKGYL 1499
++ P+GL VDWI +NIYWTD+ + VA G RK L ++PRA+ + P G++
Sbjct: 484 DIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFM 543
Query: 1500 YWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLN 1559
YW+DWG I++ L+G +V ++ +PNG+T+D RLYW D+ I + D+N
Sbjct: 544 YWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVN 603
Query: 1560 GQHRVQLVPDAK---NPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAME 1616
G +R ++ D K +PF + F+D ++WTD ++I A++ TG ++ L+ NL +
Sbjct: 604 GGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPED 663
Query: 1617 IKAV-SADRQHGWNPCKE---SNGGCSHLCL----FRGH--EYICACPD 1655
+ + + G N C+ SNGGC +LCL H ++ CACPD
Sbjct: 664 MVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPD 712
Score = 168 bits (408), Expect = 2e-40
Identities = 103/333 (30%), Positives = 168/333 (50%), Gaps = 46/333 (13%)
Query: 762 MDIHSRSCEETPE-KLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKS 820
+D H+++C+ L + R ++R K +D + + +++ VALD + S
Sbjct: 397 LDPHTKACKAVGSIAYLFFTNRHEVR------KMTLDRSEYTSLIPNLRNVVALDTEVAS 450
Query: 821 NSIFWTDVEKDTINRAYLNGSHQT----TIVDSNLIWPAGLAFDWITDKIYWTDGGTNRI 876
N I+W+D+ + I L+ +H T++ ++ P GLA DWI IYWTD +
Sbjct: 451 NRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTV 510
Query: 877 EVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFG 936
V+ + G R L ++ KPR IVV+P G MYW+DWG I++ ++G + L+
Sbjct: 511 SVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTE 570
Query: 937 QMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN---LPHPFGLDLYGDEV 993
+ WPNG+ LDL+ R+YW D +I +++G R ++E+ L HPF L ++ D+V
Sbjct: 571 NIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKV 630
Query: 994 FWTDWDTQSIQAANKDTGAKRRTLG-----------------------CGK---NNGGCS 1027
FWTD ++I +AN+ TG+ L C + +NGGC
Sbjct: 631 FWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQ 690
Query: 1028 HLCLLKPGGR------SCACPIGIKLNKDGKTC 1054
+LCL P +CACP G+ L +D ++C
Sbjct: 691 YLCLPAPQINPHSPKFTCACPDGMLLARDMRSC 723
Score = 163 bits (396), Expect = 5e-39
Identities = 135/561 (24%), Positives = 235/561 (41%), Gaps = 56/561 (9%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
++C + E R CH CI+ +++CD D DC D SDE +C V+ N+S I
Sbjct: 119 KTCSQDEFR--CHDGK-CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCI-- 173
Query: 216 VITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKC 275
P + P C + + R + + C+ +F C + +C
Sbjct: 174 ----PQLWACDNDPD--------CEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGEC 221
Query: 276 VPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDE 335
+ ++CDG DC D +DE++C + +C EF+C+DG CI +CD E DC D DE
Sbjct: 222 IHSSWRCDGGPDCKDKSDEENCAV--ATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDE 279
Query: 336 LNCKPNSIRNC-SLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ 394
+ C ++ C +++ C C+ +C+ RDC + DE E C
Sbjct: 280 VGCV--NVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKE---------CGTN 328
Query: 395 EHLMSNAFRNCVNRKHVCDGMKD-----CPRGDD---EERCPLKRKCSAEEKCEKLCITT 446
E L +N C HVC+ +K CP G + RC +C + C +LC+
Sbjct: 329 ECLDNNG--GC---SHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNL 383
Query: 447 YDGHAACACPMGFLLAEDKYSCRDIDECMY----EQDPVCSQTCSNTVGSFRCGCMTGYI 502
G+ C C GF L +C+ + Y + V T + + + +
Sbjct: 384 EGGY-KCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVV 442
Query: 503 LRPDERSCKP---TGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLV 559
E + + S ++ S ++ + D +S + +A+D+ + +
Sbjct: 443 ALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSN--I 500
Query: 560 FWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGT-RRVEVATLD 618
+W+++ L + VA + R P + VD +H ++WTD GT +++ L+
Sbjct: 501 YWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLN 560
Query: 619 GSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPN 678
G LV ++ P I + ++W D I D++G RKT++ DE +
Sbjct: 561 GVDIYSLVTENIQWPNGITLDLLSGRLYWVD-SKLHSISSIDVNGGNRKTILEDEKRLAH 619
Query: 679 GLTIDYTESKIYWADAKHHVI 699
++ E K++W D + I
Sbjct: 620 PFSLAVFEDKVFWTDIINEAI 640
Score = 133 bits (321), Expect = 6e-30
Identities = 61/170 (35%), Positives = 92/170 (54%), Gaps = 15/170 (8%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND--GKCIPE 319
RC +F+C++ KC+ + CDG +C D +DE + +C +G+F C +CIP+
Sbjct: 38 RCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQ 97
Query: 320 RWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMN 379
WRCD + DC +G DE C P + CS DE+ C D +C+ + ++CD RDC +G DE +
Sbjct: 98 FWRCDGQVDCDNGSDEQGCPP---KTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEAS 154
Query: 380 CEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE--ERC 427
C V TC P +++ C+ + CD DC G DE +RC
Sbjct: 155 CPV------LTCGPASFQCNSS--TCIPQLWACDNDPDCEDGSDEWPQRC 196
Score = 108 bits (260), Expect = 2e-22
Identities = 53/145 (36%), Positives = 73/145 (50%), Gaps = 14/145 (9%)
Query: 304 CNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADR--RCVLK 361
C EF+C DGKCI +W CD +C DG DE S+ C +++C R RC+ +
Sbjct: 39 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSV-TCKSGDFSCGGRVNRCIPQ 97
Query: 362 TWLCDGVRDCTNGEDEMNC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPR 420
W CDG DC NG DE C +C +D++ C + C++R+ VCD +DC
Sbjct: 98 FWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGK---------CISRQFVCDSDRDCLD 148
Query: 421 GDDEERCPLKRKCSAEEKC-EKLCI 444
G DE CP+ A +C CI
Sbjct: 149 GSDEASCPVLTCGPASFQCNSSTCI 173
Score = 69.7 bits (163), Expect = 9e-11
Identities = 60/279 (21%), Positives = 114/279 (40%), Gaps = 15/279 (5%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVP 1078
C NNGGCSH+C G C CP G +L + C D I+ ++L+
Sbjct: 330 CLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQ-RRCED--IDECQDPDTCSQLCVNLEGG 386
Query: 1079 YLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADG 1138
Y + S +++T+ + ++++ T + ++I N L
Sbjct: 387 YKCQCEEGFQLDPHTKACKAVGSIAYLFFTN--RHEVRKMTLDRSEYTSLIPN-LRNVVA 443
Query: 1139 IVIDSTGRKIYWTDGGRNSIEVAELDG----RNRKVLVWTGLDSPRAIALHYEYGYMFWS 1194
+ + +IYW+D + I +LD + ++ + +P +A+ + + ++W+
Sbjct: 444 LDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWT 503
Query: 1195 DWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFDGH 1253
D + AD G R+ + P + +D + G +YW D I+ +G
Sbjct: 504 D-SVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGV 562
Query: 1254 D-RRTVLSNVPYPYGIV--IVGQHIYWTDWKTKALHRAD 1289
D V N+ +P GI ++ +YW D K ++ D
Sbjct: 563 DIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSID 601
Score = 40.3 bits (90), Expect = 0.061
Identities = 22/58 (37%), Positives = 33/58 (56%), Gaps = 3/58 (5%)
Query: 1600 TGKNITLIRTNLEMAMEIKAVSAD--RQHGWNPCKESNGGCSHLCLFRGHEYICACPD 1655
+G+ ITL + MA + + S + ++ G N C ++NGGCSH+C Y C CPD
Sbjct: 298 SGECITLDKV-CNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPD 354
>AF283408-1|AAL38109.1| 1537|Homo sapiens candidate tumor suppressor
protein protein.
Length = 1537
Score = 327 bits (804), Expect = 2e-88
Identities = 178/496 (35%), Positives = 264/496 (53%), Gaps = 21/496 (4%)
Query: 263 CAEIDFECKNTK-CVPKDFQCDGDNDCGDWTDE-DSCPMVPGS-CNAGEFKCNDGKCIPE 319
CA F C+ ++ CVP+ + CDG+ DC D +DE + P + C+ F C++ CIP+
Sbjct: 85 CAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPK 144
Query: 320 RWRCDNERDCADGGDEL-NCKPNSIRNCSLDEYTCADRRCVLKT-WLCDGVRDCTNGEDE 377
++ CD++ DC DG DE C R C +E++CAD RC+L T W CDG DC + DE
Sbjct: 145 QFVCDHDDDCGDGSDESPQC---GYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDE 201
Query: 378 MNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE 437
C+ +C + N C+ +CD DC G DE C + S +
Sbjct: 202 APLNPKCKSAXQSCNSSFFMCKNG--RCIPSGGLCDNKDDCGDGSDERNCHINECLSKKV 259
Query: 438 K-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCG 496
C + C + C C GF L +D +C DIDEC CSQ C NT G+++C
Sbjct: 260 SGCSQDCQDLPVSYK-CKCWPGFQLKDDGKTCVDIDEC--SSGFPCSQQCINTYGTYKCL 316
Query: 497 CMTGYILRPDE-RSCKP-TGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHY 554
C GY ++PD CK + E P L+ ++ IR++ G NY + +GL+N +A+D+ Y
Sbjct: 317 CTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDY 376
Query: 555 EKKLVFWSENNL-RVIRVAQMNTKNMSDV-IRWGLETPAGVAVDWIHDLLFWTDSGTRRV 612
++ ++W +++ R+ +M N SD+ + P +AVDWI L+W+D+ R +
Sbjct: 377 REEFIYWIDSSRPNGSRINRM-CLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRII 435
Query: 613 EVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYD 672
EV+ L+G +LV+ L PR +++ P ++W D P I R MDG + VI
Sbjct: 436 EVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIET 495
Query: 673 EIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYW 732
+I P LTIDY ++YWAD H IE + DG R KV + +P ALTLF+D IYW
Sbjct: 496 KISRPMALTIDYVNRRLYWADENH--IEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYW 553
Query: 733 TDWHTKSISTVNKNTG 748
TD TKS+S +K +G
Sbjct: 554 TDGKTKSLSRAHKTSG 569
Score = 214 bits (522), Expect = 3e-54
Identities = 142/504 (28%), Positives = 222/504 (44%), Gaps = 41/504 (8%)
Query: 263 CAEIDFECKN-TKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
C E F CKN C+P + CDG +DC D +DE++C C A EF CN+ C W
Sbjct: 956 CKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHFW 1015
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRR-CVLKTWLCDGVRDCTNGEDEMNC 380
CD E DC D DE S + C + R C+ +C+G+ +C + DE +C
Sbjct: 1016 VCDGEDDCGDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHC 1075
Query: 381 EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC---PLKRKCSAE- 436
C+ E SN + C+ CD + DC G DE+ C P + C
Sbjct: 1076 GGKLTYKARPCKKDEFACSN--KKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNV 1133
Query: 437 EKC-EKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRC 495
C + C C GF C D++EC+ CS C N GS++C
Sbjct: 1134 NPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFG--TCSHQCINVEGSYKC 1191
Query: 496 GCMTGYILRPDERSCKPTGESPTLLF----SNRIGIRQVWLTGDNYMSVVKGLHNA--VA 549
C + R +C G +L+ ++ +G + ++ + HN+
Sbjct: 1192 VCDQNFQER--NNTCIAEGSEDQVLYIANDTDILGFIYPFNYSGDHQQISHIEHNSRITG 1249
Query: 550 LDYHYEKKLVFWSEN-NLRVIRVAQMNTKNM----SDVIRWGLETPAGVAVDWIHDLLFW 604
+D +Y++ ++ WS N I +++ + S +I + P +AVDW+ ++W
Sbjct: 1250 MDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFKRPRDIAVDWVAGNIYW 1309
Query: 605 TDSGTRR---------------VEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTD 649
TD + V L+G L+ N +P AIAV+P +++WT
Sbjct: 1310 TDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTV 1369
Query: 650 WGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDR 709
G + IE A MDG R+ ++ + P GL +DY +IYWAD + +I +DG +
Sbjct: 1370 VGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDGSNS 1429
Query: 710 -RKVTTK-GLPHPFALTLFDDAIY 731
V++K GL HP + +F+D IY
Sbjct: 1430 VVSVSSKQGLLHPHRIDIFEDYIY 1453
Score = 203 bits (496), Expect = 4e-51
Identities = 119/334 (35%), Positives = 177/334 (52%), Gaps = 18/334 (5%)
Query: 1329 CSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEE--FLIFATRGSITYISLESP 1386
CS C+ + Y C C G + P CKS +E FLI A I IS +
Sbjct: 302 CSQQCINTYGTYKCLCTDGYEIQPDN----PNGCKSLSDEEPFLILADHHEIRKISTDGS 357
Query: 1387 EQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPN 1446
+ TL + + N IA+D+ + + I++ D IN ++ S + PN
Sbjct: 358 ---NYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAVPN 414
Query: 1447 GLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITG-LTEPRALALFPAKGYLYWSDWG 1505
L VDWI N+YW+D E ++IEV++L+G +L++ L PR L+L P GYLYW D
Sbjct: 415 ALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCC 474
Query: 1506 EHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQ 1565
E+P+I R +DG+ + ++++ + P LTIDY RRLYW D ++ I+ S+++G HR
Sbjct: 475 EYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWAD--ENHIEFSNMDGSHR-H 531
Query: 1566 LVPDAKNP--FGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAVSAD 1623
VP+ P +T F+DYIYWTD KS+ RA K +G + + + +I+ +
Sbjct: 532 KVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSY 591
Query: 1624 RQHGWNP--CKESNGGCSHLCLFR-GHEYICACP 1654
RQ + C +NGGCSHLCL G + CACP
Sbjct: 592 RQPDVSKHLCMINNGGCSHLCLLAPGKTHTCACP 625
Score = 185 bits (450), Expect = 1e-45
Identities = 114/333 (34%), Positives = 172/333 (51%), Gaps = 20/333 (6%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDG----KTCADGPINYLIFAHRVDIRVISLDVPYLI 1081
CS C+ G C C G ++ D K+ +D +LI A +IR IS D
Sbjct: 302 CSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLSDEE-PFLILADHHEIRKISTDGS--- 357
Query: 1082 DVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRL---GTHVETVIGNGLHTADG 1138
+ L L N + +D D+ IYW D+ + R R+ G+ ++ V + A
Sbjct: 358 NYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAVPNA-- 415
Query: 1139 IVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGT 1198
+ +D G+ +YW+D + IEV++L+G +LV L PR ++L + GY++W D
Sbjct: 416 LAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCE 475
Query: 1199 SAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTV 1258
I R MDG N+ V+++ KI P L ID + RLYW D IE S+ DG R V
Sbjct: 476 YPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADEN--HIEFSNMDGSHRHKV 533
Query: 1259 LS-NVPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQSER- 1316
+ ++P + + +IYWTD KTK+L RA KT+ +D + + + + DI+ S R
Sbjct: 534 PNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQ 593
Query: 1317 --VLENACGTDNGGCSHLCLRSP-LGYTCACPT 1346
V ++ C +NGGCSHLCL +P +TCACPT
Sbjct: 594 PDVSKHLCMINNGGCSHLCLLAPGKTHTCACPT 626
Score = 178 bits (433), Expect = 2e-43
Identities = 137/495 (27%), Positives = 219/495 (44%), Gaps = 45/495 (9%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK-CIPERW 321
C+ F C KC+ K + CDG++DCGD DE +C A F C + C+P W
Sbjct: 44 CSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMFSCQGSRACVPRHW 103
Query: 322 RCDNERDCADGGDELN---CKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEM 378
CD ERDC DG DEL+ C PN+ C + + C ++ C+ K ++CD DC +G DE
Sbjct: 104 LCDGERDCPDGSDELSTAGCAPNN--TCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDE- 160
Query: 379 NCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKC-SAEE 437
C Q C +E ++ R +N + CDG DCP D + PL KC SA +
Sbjct: 161 --SPQCGYRQ--CGTEEFSCADG-RCLLNTQWQCDGDFDCP--DHSDEAPLNPKCKSAXQ 213
Query: 438 KCEKLCITTYDGHAACACPMGFLLAEDKYSCRD--------IDECMYEQDPVCSQTCSNT 489
C +G P G L ++K C D I+EC+ ++ CSQ C +
Sbjct: 214 SCNSSFFMCKNGR---CIPSGG-LCDNKDDCGDGSDERNCHINECLSKKVSGCSQDCQDL 269
Query: 490 VGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQV----WLTGDNYMSVVKGLH 545
S++C C G+ L+ D ++C E + ++ I L D Y +
Sbjct: 270 PVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYKCLCTDGYEIQPDNPN 329
Query: 546 NAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWT 605
+L E L+ + +R I N +++ GL + D+ + ++W
Sbjct: 330 GCKSLS-DEEPFLILADHHEIRKISTDGSN----YTLLKQGLNNVIAIDFDYREEFIYWI 384
Query: 606 DSGT---RRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMD 662
DS R+ L+GS + V ++ P A+AV ++W+D IE + ++
Sbjct: 385 DSSRPNGSRINRMCLNGSD--IKVVHNTAVPNALAVDWIGKNLYWSD-TEKRIIEVSKLN 441
Query: 663 GDKRKTVIYDEIFWPNGLTIDYTESKIYWAD-AKHHVIERAAFDGRDRRKVTTKGLPHPF 721
G ++ + +P L++D +YW D ++ I R DG ++ V + P
Sbjct: 442 GLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPM 501
Query: 722 ALTL--FDDAIYWTD 734
ALT+ + +YW D
Sbjct: 502 ALTIDYVNRRLYWAD 516
Score = 169 bits (410), Expect = 1e-40
Identities = 100/287 (34%), Positives = 149/287 (51%), Gaps = 33/287 (11%)
Query: 797 DSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDT---INRAYLNGSHQTTIVDSNLIW 853
D + + + + + +A+D+D + I+W D + INR LNGS + N
Sbjct: 355 DGSNYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVV--HNTAV 412
Query: 854 PAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSD 913
P LA DWI +YW+D IEVSK +G T+L + PRD+ ++P+ G +YW D
Sbjct: 413 PNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWID 472
Query: 914 WGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGR 973
P I R MDG N+ +I +++ P L +D V+ R+YW D + IE++N+DG+ R
Sbjct: 473 CCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADENH--IEFSNMDGSHR 530
Query: 974 TKL-IENLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTL--------------- 1017
K+ +++P L L+ D ++WTD T+S+ A+K +GA R +L
Sbjct: 531 HKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHS 590
Query: 1018 ---------GCGKNNGGCSHLCLLKPG-GRSCACPIGIKLNKDGKTC 1054
C NNGGCSHLCLL PG +CACP L D +TC
Sbjct: 591 YRQPDVSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTC 637
Score = 163 bits (396), Expect = 5e-39
Identities = 83/218 (38%), Positives = 117/218 (53%), Gaps = 19/218 (8%)
Query: 263 CAEIDFECKNTK-CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
C+ F+CK TK C+ K + CD D DC D +DE +C +C EF+C + CIP+ W
Sbjct: 760 CSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKK--TCGPHEFQCKNNNCIPDHW 817
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCE 381
RCD++ DC+D DE NCKP + C+L ++ CA+ CV + CDG DC +G DE NCE
Sbjct: 818 RCDSQNDCSDNSDEENCKP---QTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNCE 874
Query: 382 VSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC-PLKRKCSAEEKCE 440
SC +DQ+ C SN C+ K CDG +DC G+DE+ C P CS+ E
Sbjct: 875 TSCSKDQFRC-------SNG--QCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSR---E 922
Query: 441 KLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQ 478
+C + A+ C + A+ + EC +Q
Sbjct: 923 YICASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQ 960
Score = 140 bits (340), Expect = 3e-32
Identities = 85/256 (33%), Positives = 118/256 (46%), Gaps = 31/256 (12%)
Query: 263 CAEIDFEC-KNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK-CIPER 320
C F+C KN KC+P + +C+G +DCGD DE CP SC+ F+C K CI +
Sbjct: 720 CLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCP--ENSCSPDYFQCKTTKHCISKL 777
Query: 321 WRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC 380
W CD + DCAD DE NC + C E+ C + C+ W CD DC++ DE NC
Sbjct: 778 WVCDEDPDCADASDEANCDK---KTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENC 834
Query: 381 EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE-KC 439
+ TC ++ L +N +CV+ + CDG DC G DE C + CS ++ +C
Sbjct: 835 K------PQTCTLKDFLCANG--DCVSSRFWCDGDFDCADGSDERNC--ETSCSKDQFRC 884
Query: 440 EK-LCITT---YDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC-SQTCSNTVGSFR 494
CI DGH C ED+ SC ++ +C S C + S +
Sbjct: 885 SNGQCIPAKWKCDGHEDCK------YGEDEKSCEPASPTCSSREYICASDGCIS--ASLK 936
Query: 495 CGCMTGYILRPDERSC 510
C DE C
Sbjct: 937 CNGEYDCADGSDEMDC 952
Score = 135 bits (327), Expect = 1e-30
Identities = 71/213 (33%), Positives = 102/213 (47%), Gaps = 24/213 (11%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C++ F C N +C+P ++CDG DC DE SC +C++ E+ C CI +
Sbjct: 877 CSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASDGCISASLK 936
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADR-RCVLKTWLCDGVRDCTNGEDEMNCE 381
C+ E DCADG DE++C + C D++ C ++ C+ WLCDG+ DC +G DE N
Sbjct: 937 CNGEYDCADGSDEMDC----VTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEEN-- 990
Query: 382 VSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEK 441
CE CR E L +N+ C VCDG DC GD+ + P + C K
Sbjct: 991 --CERGGNICRADEFLCNNSL--CKLHFWVCDGEDDC--GDNSDEAP--------DMCVK 1036
Query: 442 LCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
+ H C + + + C IDEC
Sbjct: 1037 FLCPSTRPH---RCRNNRICLQSEQMCNGIDEC 1066
Score = 128 bits (308), Expect = 2e-28
Identities = 66/177 (37%), Positives = 91/177 (51%), Gaps = 9/177 (5%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
+C E F C + +C+ + CDG DC D DE C SC+ +F C+ KCI + W
Sbjct: 5 KCEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHCD---SSCSWNQFACSAQKCISKHW 61
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTC-ADRRCVLKTWLCDGVRDCTNGEDEMNC 380
CD E DC DG DE + +I C+ D ++C R CV + WLCDG RDC +G DE++
Sbjct: 62 ICDGEDDCGDGLDESDSICGAI-TCAADMFSCQGSRACVPRHWLCDGERDCPDGSDELS- 119
Query: 381 EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE 437
C + TC + N + C+ ++ VCD DC G DE R+C EE
Sbjct: 120 TAGCAPNN-TCDENAFMCHN--KVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEE 173
Score = 126 bits (303), Expect = 1e-27
Identities = 65/181 (35%), Positives = 89/181 (49%), Gaps = 17/181 (9%)
Query: 260 LMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDE-DSCPMVPGSCNAGEFKCNDGKCIP 318
L C F CK KC+P ++CD +DCGD +DE D CP C G F+C G C
Sbjct: 638 LSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEF--RCQPGRFQCGTGLCAL 695
Query: 319 ERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCA-DRRCVLKTWLCDGVRDCTNGEDE 377
+ CD E DC D DELNC + C ++ C +++C+ C+G DC + EDE
Sbjct: 696 PAFICDGENDCGDNSDELNCDTHV---CLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDE 752
Query: 378 MNC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAE 436
+C E SC D + C+ +H C+++ VCD DC DE C K+ C
Sbjct: 753 RDCPENSCSPDYFQCKTTKH--------CISKLWVCDEDPDCADASDEANCD-KKTCGPH 803
Query: 437 E 437
E
Sbjct: 804 E 804
Score = 111 bits (268), Expect = 2e-23
Identities = 91/356 (25%), Positives = 150/356 (42%), Gaps = 36/356 (10%)
Query: 1327 GGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSIT---YISL 1383
G CSH C+ Y C C +T + ++ L A I Y
Sbjct: 1176 GTCSHQCINVEGSYKCVCDQNFQERNNTCI-----AEGSEDQVLYIANDTDILGFIYPFN 1230
Query: 1384 ESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFY-TDLDLNVI---RSINMTNMSESKTIIS 1439
S + ++ ++ +D ++ MI + T + I R + +I
Sbjct: 1231 YSGDHQQIS-HIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLIC 1289
Query: 1440 QKLETPNGLGVDWIANNIYWTDNEHK---------------VIEVARLDGSSRKVLITGL 1484
+ + P + VDW+A NIYWTD+ I V +L+G + L+T +
Sbjct: 1290 PEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNM 1349
Query: 1485 T-EPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRL 1543
EP A+A+ P +G +YW+ G+H +IE + +DG+ R+I+VQ +L P GL +DY R+
Sbjct: 1350 AGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERI 1409
Query: 1544 YWTDALKDRIDTSDLNGQHRVQLVPDAK---NPFGMTQFKDYIYWTDWYKKSIIRADKRT 1600
YW D I + +G + V V + +P + F+DYIY K + R K
Sbjct: 1410 YWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAG-PKNGVFRVQKFG 1468
Query: 1601 GKNITLIRTNLEMAMEIKAVSADRQHGW-NPCKESNGGCSHLCLFRGHEYICACPD 1655
++ + N++ + +Q NPC + C LCL C CP+
Sbjct: 1469 HGSVEYLALNIDKTKGVLISHRYKQLDLPNPCLDL--ACEFLCLLNPSGATCVCPE 1522
Score = 101 bits (243), Expect = 2e-20
Identities = 92/351 (26%), Positives = 146/351 (41%), Gaps = 30/351 (8%)
Query: 1024 GGCSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGPINYLIF-AHRVDIRVISLDVPYLI 1081
G CSH C+ G C C + + TC A+G + +++ A+ DI Y
Sbjct: 1176 GTCSHQCINVEGSYKCVCDQNFQ--ERNNTCIAEGSEDQVLYIANDTDILGFIYPFNYSG 1233
Query: 1082 D--VVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTAD-- 1137
D + + G+DV + +I W+ R+ + +GL +
Sbjct: 1234 DHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFK 1293
Query: 1138 ---GIVIDSTGRKIYWTDGGRN---------------SIEVAELDGRNRKVLVWTGLDSP 1179
I +D IYWTD R SI V +L+G N L+ P
Sbjct: 1294 RPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEP 1353
Query: 1180 RAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND 1239
AIA++ + G M+W+ G + IE A MDG RR++V ++ P GLA+D R+YW D
Sbjct: 1354 YAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWAD 1413
Query: 1240 AKILTIESSDFDGHDRRTVLSN---VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDP 1296
++ I S +DG + +S+ + +P+ I I +IY K + R K
Sbjct: 1414 FELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPK-NGVFRVQKFGHGSV 1472
Query: 1297 IVIRKNLEGLMDIRAIQSERVLENACGTDNGGCSHLCLRSPLGYTCACPTG 1347
+ N++ + + L+ + C LCL +P G TC CP G
Sbjct: 1473 EYLALNIDKTKGVLISHRYKQLDLPNPCLDLACEFLCLLNPSGATCVCPEG 1523
Score = 97.9 bits (233), Expect = 3e-19
Identities = 63/214 (29%), Positives = 88/214 (41%), Gaps = 21/214 (9%)
Query: 303 SCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKT 362
+C A +F+C KCIP W+CD DC DG DE + P C + C C L
Sbjct: 640 NCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEF--RCQPGRFQCGTGLCALPA 697
Query: 363 WLCDGVRDCTNGEDEMNCEVS-CEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRG 421
++CDG DC + DE+NC+ C Q+ C + C+ C+G DC
Sbjct: 698 FICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQ--------KCIPVNLRCNGQDDCGDE 749
Query: 422 DDEERCPLKRKCSAEE---KCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQ 478
+DE CP + CS + K K CI+ C A D+ +C D C +
Sbjct: 750 EDERDCP-ENSCSPDYFQCKTTKHCISKL---WVCDEDPDCADASDEANC-DKKTCGPHE 804
Query: 479 DPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP 512
+ C +RC DE +CKP
Sbjct: 805 FQCKNNNC--IPDHWRCDSQNDCSDNSDEENCKP 836
Score = 95.1 bits (226), Expect = 2e-18
Identities = 58/180 (32%), Positives = 83/180 (46%), Gaps = 24/180 (13%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIAL 226
C + C+ WLCDG+ DC D SDE++ T+ P+ N + + V I
Sbjct: 92 CQGSRACVPRHWLCDGERDCPDGSDELS-----TAGCAPNNTCDENA--FMCHNKVCI-- 142
Query: 227 TKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKC-VPKDFQCDGD 285
V ++ C + +P+ + Q C +F C + +C + +QCDGD
Sbjct: 143 -PKQFVCDHDDDCGD---GSDESPQCGYRQ------CGTEEFSCADGRCLLNTQWQCDGD 192
Query: 286 NDCGDWTDE----DSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPN 341
DC D +DE C SCN+ F C +G+CIP CDN+ DC DG DE NC N
Sbjct: 193 FDCPDHSDEAPLNPKCKSAXQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHIN 252
Score = 89.4 bits (212), Expect = 1e-16
Identities = 104/403 (25%), Positives = 155/403 (38%), Gaps = 72/403 (17%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
++C HE + C + N CI W CD NDC D SDE NC +T L A+ GD
Sbjct: 798 KTCGPHEFQ--CKNNN-CIPDHWRCDSQNDCSDNSDEENCK-PQTCTLKDFLCAN---GD 850
Query: 216 VITNPTVL---IALTKPTVVIRYESFCAKKAL--DNAANPRSTWN-QPVELMRCAEIDFE 269
+++ + E+ C+K N + W E + E +
Sbjct: 851 CVSSRFWCDGDFDCADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKS 910
Query: 270 CK--NTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDG--------KCIPE 319
C+ + C +++ C D C CN GE+ C DG +C +
Sbjct: 911 CEPASPTCSSREYICASD----------GCISASLKCN-GEYDCADGSDEMDCVTECKED 959
Query: 320 RWRCDNE-------------RDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCD 366
++RC N+ DC DG DE NC+ C DE+ C + C L W+CD
Sbjct: 960 QFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGG-NICRADEFLCNNSLCKLHFWVCD 1018
Query: 367 GVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEER 426
G DC + DE C ++ C R C+ + +C+G+ +C DE+
Sbjct: 1019 GEDDCGDNSDE--APDMCV--KFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDH 1074
Query: 427 CPLK-----RKCSAEE-KC-EKLCI------TTYDGHAACACPMGFLLAEDKYSCRD-ID 472
C K R C +E C K CI D + G +A +Y+C D ++
Sbjct: 1075 CGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVN 1134
Query: 473 ECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C D C+Q + S C C G+ R C+ E
Sbjct: 1135 PC--GDDAYCNQIKT----SVFCRCKPGFQRNMKNRQCEDLNE 1171
Score = 81.0 bits (191), Expect = 4e-14
Identities = 70/241 (29%), Positives = 96/241 (39%), Gaps = 40/241 (16%)
Query: 854 PAGLAFDWITDKIYWTDGGTNR---------------IEVSKSDGSMRTLLAWDHIDKPR 898
P +A DW+ IYWTD I V + +G T L + +P
Sbjct: 1295 PRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPY 1354
Query: 899 DIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDG 958
I VNP+ G+MYW+ G IE A MDG R+ L+ + P GLA+D RIYW D
Sbjct: 1355 AIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADF 1414
Query: 959 GNKTIEYANLDGTGRTKLI---ENLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGA-KR 1014
I DG+ + + L HP +D++ D ++ + G+ +
Sbjct: 1415 ELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKNGVFRVQKFGHGSVEY 1474
Query: 1015 RTLGCGKNNG-------------------GCSHLCLLKPGGRSCACPIGIKLNKDGKTCA 1055
L K G C LCLL P G +C CP G K +G TC
Sbjct: 1475 LALNIDKTKGVLISHRYKQLDLPNPCLDLACEFLCLLNPSGATCVCPEG-KYLING-TCN 1532
Query: 1056 D 1056
D
Sbjct: 1533 D 1533
Score = 79.0 bits (186), Expect = 1e-13
Identities = 74/287 (25%), Positives = 107/287 (37%), Gaps = 36/287 (12%)
Query: 111 DDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTICHST 170
D+ C+T C + F C+ CIP+ R + +
Sbjct: 948 DEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNN 1007
Query: 171 NVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPT 230
++C W+CDG++DCGD SDE VK L PS T P
Sbjct: 1008 SLCKLHFWVCDGEDDCGDNSDEAPDMCVK--FLCPS-----------TRPH---RCRNNR 1051
Query: 231 VVIRYESFC--AKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDC 288
+ ++ E C + DN+ + C + +F C N KC+P D QCD +DC
Sbjct: 1052 ICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDC 1111
Query: 289 GDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDEL--NCKPNSIRNC 346
GD +DE C + P E+ C D P C ++ C + CKP RN
Sbjct: 1112 GDGSDEQGCRIAP-----TEYTCED-NVNP----CGDDAYCNQIKTSVFCRCKPGFQRN- 1160
Query: 347 SLDEYTCADRRCVLKTWLCDGVRDCTN--GEDEMNCEVSCEEDQYTC 391
+ C D L C C N G + C+ + +E TC
Sbjct: 1161 -MKNRQCEDLNECLVFGTCS--HQCINVEGSYKCVCDQNFQERNNTC 1204
Score = 68.1 bits (159), Expect = 3e-10
Identities = 72/269 (26%), Positives = 114/269 (42%), Gaps = 19/269 (7%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPY- 1079
K GCS C P C C G +L DGKTC D I+ + I+ Y
Sbjct: 257 KKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVD--IDECSSGFPCSQQCINTYGTYK 314
Query: 1080 --LIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTAD 1137
D P N D LI +I++ + G++ T++ GL+
Sbjct: 315 CLCTDGYEIQPDNPNGCKSLSDEEPFLIL---ADHHEIRKISTDGSNY-TLLKQGLNNVI 370
Query: 1138 GIVIDSTGRKIYWTDGGR---NSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWS 1194
I D IYW D R + I L+G + KV+ T + P A+A+ + ++WS
Sbjct: 371 AIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAV--PNALAVDWIGKNLYWS 428
Query: 1195 DWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFDGH 1253
D IE + ++G ++V ++K+P L++D G LYW D + I DG
Sbjct: 429 D-TEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGT 487
Query: 1254 DRRTVL-SNVPYPYGIVI--VGQHIYWTD 1279
++ V+ + + P + I V + +YW D
Sbjct: 488 NQSVVIETKISRPMALTIDYVNRRLYWAD 516
Score = 59.3 bits (137), Expect = 1e-07
Identities = 54/217 (24%), Positives = 90/217 (41%), Gaps = 16/217 (7%)
Query: 680 LTIDYTESKIYWADAKH---HVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWH 736
+ DY E IYW D+ I R +G D + V +P+ A+ +YW+D
Sbjct: 372 IDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTE 431
Query: 737 TKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESKKPI 796
+ I N V L P D+ P+ LY D + +
Sbjct: 432 KRIIEVSKLNGLYPTILVSKRLKFPRDL-----SLDPQAGYLY--WIDCCEYPHIGRVGM 484
Query: 797 DSLDMVIPVET-IKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPA 855
D + + +ET I +AL D + ++W D ++ I + ++GSH+ + + ++ P
Sbjct: 485 DGTNQSVVIETKISRPMALTIDYVNRRLYWAD--ENHIEFSNMDGSHRHKVPNQDI--PG 540
Query: 856 GLAFDWITDKIYWTDGGTNRI-EVSKSDGSMRTLLAW 891
+A D IYWTDG T + K+ G+ R L +
Sbjct: 541 VIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIY 577
Score = 50.4 bits (115), Expect = 6e-05
Identities = 37/113 (32%), Positives = 51/113 (45%), Gaps = 12/113 (10%)
Query: 88 SLQKAID---VIHTDPDDGPLNEGTEDDAGCITPCLKINFSCQISCTCIPME-----KRX 139
S QK I + + D G + ++ G IT C FSCQ S C+P +R
Sbjct: 52 SAQKCISKHWICDGEDDCGDGLDESDSICGAIT-CAADMFSCQGSRACVPRHWLCDGERD 110
Query: 140 XXXXXXXXXXXXXXXXRSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDE 192
+CDE N +CH+ VCI +++CD D+DCGD SDE
Sbjct: 111 CPDGSDELSTAGCAPNNTCDE--NAFMCHN-KVCIPKQFVCDHDDDCGDGSDE 160
Score = 50.4 bits (115), Expect = 6e-05
Identities = 31/90 (34%), Positives = 39/90 (43%), Gaps = 8/90 (8%)
Query: 111 DDAGCITP-CLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHE---NRTI 166
D+ C T CL F C + CIP+ R R C E+ +
Sbjct: 711 DELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDE----RDCPENSCSPDYFQ 766
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCD 196
C +T CI+ W+CD D DC D SDE NCD
Sbjct: 767 CKTTKHCISKLWVCDEDPDCADASDEANCD 796
Score = 47.6 bits (108), Expect = 4e-04
Identities = 26/86 (30%), Positives = 36/86 (41%), Gaps = 2/86 (2%)
Query: 111 DDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTICHST 170
D+ C++ C F C+ CIP + R C T
Sbjct: 633 DNRTCLSNCTASQFRCKTD-KCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQC-GT 690
Query: 171 NVCIALEWLCDGDNDCGDFSDEINCD 196
+C ++CDG+NDCGD SDE+NCD
Sbjct: 691 GLCALPAFICDGENDCGDNSDELNCD 716
Score = 45.6 bits (103), Expect = 0.002
Identities = 33/131 (25%), Positives = 62/131 (47%), Gaps = 3/131 (2%)
Query: 825 WTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWT-DGGTNRIEVSKSDG 883
WT + + +IN LNG + T ++ + P +A + +YWT G + IE + DG
Sbjct: 1325 WTSL-RYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDG 1383
Query: 884 SMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNG 943
++R +L ++ +P + V+ +YW+D+ S I DG N + + +
Sbjct: 1384 TLRRILVQKNLQRPTGLAVDYFSERIYWADFELS-IIGSVLYDGSNSVVSVSSKQGLLHP 1442
Query: 944 LALDLVHNRIY 954
+D+ + IY
Sbjct: 1443 HRIDIFEDYIY 1453
Score = 43.6 bits (98), Expect = 0.007
Identities = 24/73 (32%), Positives = 39/73 (53%), Gaps = 1/73 (1%)
Query: 813 ALDWDQKSNSIFWTDV-EKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDG 871
A+ + K ++WT V + I A ++G+ + +V NL P GLA D+ +++IYW D
Sbjct: 1355 AIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADF 1414
Query: 872 GTNRIEVSKSDGS 884
+ I DGS
Sbjct: 1415 ELSIIGSVLYDGS 1427
Score = 39.5 bits (88), Expect = 0.11
Identities = 22/85 (25%), Positives = 36/85 (42%), Gaps = 1/85 (1%)
Query: 111 DDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTICHST 170
D+ C T C K F C + CIP + + + +R ++
Sbjct: 869 DERNCETSCSKDQFRCS-NGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICAS 927
Query: 171 NVCIALEWLCDGDNDCGDFSDEINC 195
+ CI+ C+G+ DC D SDE++C
Sbjct: 928 DGCISASLKCNGEYDCADGSDEMDC 952
Score = 39.1 bits (87), Expect = 0.14
Identities = 17/35 (48%), Positives = 19/35 (54%), Gaps = 1/35 (2%)
Query: 162 ENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCD 196
EN C S CI W+CDG DC D DE +CD
Sbjct: 8 ENYFSCPSGR-CILNTWICDGQKDCEDGRDEFHCD 41
Score = 38.7 bits (86), Expect = 0.19
Identities = 15/30 (50%), Positives = 20/30 (66%), Gaps = 1/30 (3%)
Query: 163 NRTICHSTNVCIALEWLCDGDNDCGDFSDE 192
N+ C S CI+ W+CDG++DCGD DE
Sbjct: 47 NQFAC-SAQKCISKHWICDGEDDCGDGLDE 75
>AC008178-1|AAY24266.1| 773|Homo sapiens unknown protein.
Length = 773
Score = 313 bits (768), Expect = 4e-84
Identities = 164/493 (33%), Positives = 259/493 (52%), Gaps = 28/493 (5%)
Query: 270 CKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDC 329
C N C +CD DC D +DE +C + C EF C +G+CIP + CD++ DC
Sbjct: 152 CDNGACYNTSQKCDWKVDCRDSSDEINCTEI---CLHNEFSCGNGECIPRAYVCDHDNDC 208
Query: 330 ADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQY 389
DG DE C + C ++TC RC+ + W+CDG DC + DE CE S D +
Sbjct: 209 QDGSDEHAC---NYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCE-SGPHDVH 264
Query: 390 TCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCS----AEEKCEKLCIT 445
C P+E + R C++ VCDG+ DCP +DE + CS + C+ C
Sbjct: 265 KCSPREWSCPESGR-CISIYKVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQYQCHE 323
Query: 446 TYDGHAACACPMGFLLAE-DKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILR 504
T G AC CP G+++ D +C + D+C +C Q C + G C C GYIL
Sbjct: 324 TPYG-GACFCPPGYIINHNDSRTCVEFDDCQIWG--ICDQKCESRPGRHLCHCEEGYILE 380
Query: 505 PDERSCKPT---GESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALD--YHYEKKLV 559
+ CK GE+ +++FSN + + G ++ +V+ + VA+ +HY + V
Sbjct: 381 RGQY-CKANDSFGEA-SIIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYHLQRV 438
Query: 560 FWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDG 619
FW++ + +N N+ +V+ +ETP +AVDW+++ ++ ++ R+++ LDG
Sbjct: 439 FWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDG 498
Query: 620 SKRAVLVANDLDKPRAIAVHPGDALVFWTDW---GPNPKIERADMDGDKRKTVIYDEIFW 676
S R L+ +L PR IAV P +F++DW PK+ERA MDG RK ++ ++ W
Sbjct: 499 SYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGW 558
Query: 677 PNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKG--LPHPFALTLFDDAIYWTD 734
P G+T+D ++YW D++ IE +DG R+ V G +PHPF ++LF+ +++TD
Sbjct: 559 PAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTD 618
Query: 735 WHTKSISTVNKNT 747
W ++ NK T
Sbjct: 619 WTKMAVLKANKFT 631
Score = 183 bits (445), Expect = 6e-45
Identities = 122/418 (29%), Positives = 207/418 (49%), Gaps = 26/418 (6%)
Query: 1024 GGCSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGPINY--LIFAHRVDIRVISLDVPYL 1080
G C C +PG C C G L + G+ C A+ +IF++ D+ + +
Sbjct: 356 GICDQKCESRPGRHLCHCEEGYILER-GQYCKANDSFGEASIIFSNGRDLLIGDIH-GRS 413
Query: 1081 IDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIV 1140
+++ A+GV + ++WTDT Q K+ G +++ V+ + T + +
Sbjct: 414 FRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLA 473
Query: 1141 IDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGT-- 1198
+D KIY + N I++ LDG R L+ L PR IA+ GY+F+SDW +
Sbjct: 474 VDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLS 533
Query: 1199 -SAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRT 1257
K+ERA MDG+NR+ +V K+ WP G+ +D I R+YW D++ IE+ +DG R+T
Sbjct: 534 GEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKT 593
Query: 1258 VL---SNVPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQS 1314
V+ S +P+P+G+ + +++TDW A+ +A+K ++P V + + S
Sbjct: 594 VVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHS 653
Query: 1315 ER--VLENACGTDNGGCSHLCLRS------PLGYTCACPTGMPFEKSTTDQTPKKCKSHP 1366
R N C +NGGC +C+ S LG+ C C G + TD+ + C +
Sbjct: 654 LRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLD---TDE--RHCIA-V 707
Query: 1367 EEFLIFATRGSITYISLESPEQWDVTLPVK-EVKNTIAVDYHWDLKMIFYTDLDLNVI 1423
+ FLIF+++ +I I Q DV +PV + +D+ IF++D+ ++I
Sbjct: 708 QNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMI 765
Score = 180 bits (438), Expect = 4e-44
Identities = 114/386 (29%), Positives = 188/386 (48%), Gaps = 41/386 (10%)
Query: 774 EKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTI 833
E ++++ +DL + + + S +++ + AV + + +FWTD ++ +
Sbjct: 393 EASIIFSNGRDLLIGDIHGR----SFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKV 448
Query: 834 NRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDH 893
+NG + +++ ++ P LA DW+ +KIY + NRI++ DGS R L ++
Sbjct: 449 FSVDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITEN 508
Query: 894 IDKPRDIVVNPEGGVMYWSDW---GASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVH 950
+ PR I V+P G +++SDW P +ERA MDG NRK L+ ++ WP G+ LD++
Sbjct: 509 LGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMIS 568
Query: 951 NRIYWTDGGNKTIEYANLDGTGRTKLIEN---LPHPFGLDLYGDEVFWTDWDTQSIQAAN 1007
R+YW D IE DG R ++ +PHPFG+ L+ +VF+TDW ++ AN
Sbjct: 569 KRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKAN 628
Query: 1008 KDT--------GAKRRTLG---------------CGKNNGGCSHLCLLKPG------GRS 1038
K T A R G C NNGGC +C+L G
Sbjct: 629 KFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFR 688
Query: 1039 CACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKN-ALGVD 1097
C C G +L+ D + C N+LIF+ +V IR I + DV++P+ + +G+D
Sbjct: 689 CKCTFGFQLDTDERHCI-AVQNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGID 747
Query: 1098 VDHSTGLIYWTDTGQRKIQRATRLGT 1123
D I+++D + I + GT
Sbjct: 748 FDAQDSTIFFSDMSKHMIFKQKIDGT 773
Score = 176 bits (428), Expect = 7e-43
Identities = 99/325 (30%), Positives = 171/325 (52%), Gaps = 13/325 (4%)
Query: 1327 GGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESP 1386
G C C P + C C G E+ Q K S E +IF+ + +
Sbjct: 356 GICDQKCESRPGRHLCHCEEGYILERG---QYCKANDSFGEASIIFSNGRDLLIGDIHG- 411
Query: 1387 EQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPN 1446
+ + + + + V +H+ L+ +F+TD N + S+++ ++ + +++ +ETP
Sbjct: 412 RSFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQE-VLNVSVETPE 470
Query: 1447 GLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLIT-GLTEPRALALFPAKGYLYWSDWG 1505
L VDW+ N IY + + I++ LDGS R LIT L PR +A+ P GYL++SDW
Sbjct: 471 NLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWE 530
Query: 1506 E---HPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQH 1562
P +ER+++DGS R+ +V+ LG+P G+T+D +R+YW D+ D I+T +G
Sbjct: 531 SLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQ 590
Query: 1563 RVQLVPDAK---NPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKA 1619
R +V +PFG++ F+ +++TDW K ++++A+K T N + +
Sbjct: 591 RKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTV 650
Query: 1620 VSADRQ-HGWNPCKESNGGCSHLCL 1643
+ RQ + NPCK++NGGC +C+
Sbjct: 651 YHSLRQPYATNPCKDNNGGCEQVCV 675
Score = 169 bits (412), Expect = 6e-41
Identities = 162/628 (25%), Positives = 263/628 (41%), Gaps = 73/628 (11%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
+ CD R C S + CI +W CDG DC D +DEI C VV + G
Sbjct: 26 QECDSAHFR--CGSGH-CIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSE---GQ 79
Query: 216 VITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKC 275
I N + V + C D+ ++ R +Q C+ C N +C
Sbjct: 80 CIPN----------SWVCDQDQDC-----DDGSDERQDCSQST----CSSHQITCSNGQC 120
Query: 276 VPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDE 335
+P +++CD DC D DE+ C P +C + C++G C +CD + DC D DE
Sbjct: 121 IPSEYRCDHVRDCPDGADENDC-QYP-TCE--QLTCDNGACYNTSQKCDWKVDCRDSSDE 176
Query: 336 LNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV-SCEEDQYTCRPQ 394
+NC + N E++C + C+ + ++CD DC +G DE C +C Q+TC P
Sbjct: 177 INCTEICLHN----EFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTC-PS 231
Query: 395 EHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPL----KRKCSAEE-KCEK--LCITTY 447
C+ + VCDG DC DE+ C KCS E C + CI+ Y
Sbjct: 232 --------GRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIY 283
Query: 448 DGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV--CSQTCSNTVGSFRCGCMTGYIL-R 504
C + ED+ + C C C T C C GYI+
Sbjct: 284 ---KVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYIINH 340
Query: 505 PDERSCKPTGESP-----TLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLV 559
D R+C + +R G R + + Y+ + +G + A D E ++
Sbjct: 341 NDSRTCVEFDDCQIWGICDQKCESRPG-RHLCHCEEGYI-LERGQY-CKANDSFGEASII 397
Query: 560 FWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDG 619
F + +L + + + + + + G+ GVA + +FWTD+ +V ++G
Sbjct: 398 FSNGRDLLIGDIHGRSFRILVESQNRGV--AVGVAFHYHLQRVFWTDTVQNKVFSVDING 455
Query: 620 SKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNG 679
++ ++ P +AV + ++ + N +I+ ++DG R T+I + + P G
Sbjct: 456 LNIQEVLNVSVETPENLAVDWVNNKIYLVETKVN-RIDMVNLDGSYRVTLITENLGHPRG 514
Query: 680 LTIDYTESKIYWAD----AKHHVIERAAFDGRDRRK-VTTK-GLPHPFALTLFDDAIYWT 733
+ +D T ++++D + +ERA DG +R+ V TK G P L + +YW
Sbjct: 515 IAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWV 574
Query: 734 DWHTKSISTVNKNTGMGIQTVHAGLNVP 761
D I TV + VH G +P
Sbjct: 575 DSRFDYIETVTYDGIQRKTVVHGGSLIP 602
Score = 128 bits (308), Expect = 2e-28
Identities = 66/174 (37%), Positives = 90/174 (51%), Gaps = 19/174 (10%)
Query: 257 PVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKC-NDGK 315
P C F C + C+P D++CDG DC D DE C +V +C G FKC ++G+
Sbjct: 22 PASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVV--TCQQGYFKCQSEGQ 79
Query: 316 CIPERWRCDNERDCADGGDE-LNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNG 374
CIP W CD ++DC DG DE +C ++ CS + TC++ +C+ + CD VRDC +G
Sbjct: 80 CIPNSWVCDQDQDCDDGSDERQDCSQST---CSSHQITCSNGQCIPSEYRCDHVRDCPDG 136
Query: 375 EDEMNCEV-SCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC 427
DE +C+ +CE Q TC N C N CD DC DE C
Sbjct: 137 ADENDCQYPTCE--QLTC-------DNG--ACYNTSQKCDWKVDCRDSSDEINC 179
Score = 64.9 bits (151), Expect = 2e-09
Identities = 44/154 (28%), Positives = 66/154 (42%), Gaps = 26/154 (16%)
Query: 340 PNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV-SCEEDQYTCRPQEHLM 398
P S + C + C C+ W CDG +DC++ DE+ C V +C++ + C+ +
Sbjct: 22 PASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQ-- 79
Query: 399 SNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE-KCEK-LCI-TTYDGHAACAC 455
C+ VCD +DC G DE + + CS+ + C CI + Y C
Sbjct: 80 ------CIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDC 133
Query: 456 PMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSN 488
P G D ++C Y P C Q TC N
Sbjct: 134 PDG----------ADENDCQY---PTCEQLTCDN 154
Score = 37.5 bits (83), Expect = 0.43
Identities = 29/97 (29%), Positives = 46/97 (47%), Gaps = 6/97 (6%)
Query: 477 EQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQV---WLT 533
EQ V S N FRC C G+ L DER C L+FS+++ IR + T
Sbjct: 671 EQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHC--IAVQNFLIFSSQVAIRGIPFTLST 728
Query: 534 GDNYMSVVKGLHN-AVALDYHYEKKLVFWSENNLRVI 569
++ M V G + V +D+ + +F+S+ + +I
Sbjct: 729 QEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMI 765
>AF283342-1|AAL38107.1| 881|Homo sapiens candidate tumor suppressor
protein protein.
Length = 881
Score = 304 bits (747), Expect = 2e-81
Identities = 206/668 (30%), Positives = 330/668 (49%), Gaps = 42/668 (6%)
Query: 1024 GGCSHLCLLKPGGRSCACPIGIKLNKDGKTC------ADGPINYLIFAHRVDIRVISLDV 1077
G CS C G +C+C G + D ++C D P L+ A+ I V L+
Sbjct: 163 GTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRP-PILLIANFETIEVFYLNG 221
Query: 1078 PYLIDVVLPLPPLKNALGVDVDHSTGLIYWTDT----GQRKIQRATRLG--THVETV-IG 1130
+ L +D ++ +I W ++ Q K + T+ G T T+ I
Sbjct: 222 SKM--ATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINIL 279
Query: 1131 NGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGY 1190
H + ID R +Y+ D + I V +G L+ L +P+AIA+ G
Sbjct: 280 QSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGK 339
Query: 1191 MFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDF 1250
+F++D+G AK+ER DMDG NR I+D+K + P LA+D + +YW D + + D+
Sbjct: 340 LFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDY 399
Query: 1251 DGHDRRTVLS--NVPYPYGIVIVGQHIYWTDWKTKALHRADKTNASD--PIVIRKNLEGL 1306
G +R TV+ V + YGI + ++Y T+ + R ++ N +D ++ +N G+
Sbjct: 400 QGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIKIENAWGI 459
Query: 1307 MDIRAIQSERVLENACGTD----NGGCSHLCLRSP--LGYTCACPTGMPFEKSTTDQTPK 1360
+ V +AC D GGCSH+CL S TC C TG F + ++ K
Sbjct: 460 RIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTG--FNLGSDGRSYK 517
Query: 1361 KCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDL 1420
+ K+ F G + + L + + +P++ + N A+D+H + I++ D
Sbjct: 518 RPKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTS 577
Query: 1421 NVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEH-KVIEVARLD--GSSR 1477
+I + +E +TI+ L+ G+ VDWI NN+YWT++ H K I VARL+ SR
Sbjct: 578 FLIGRQKIDG-TERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSR 636
Query: 1478 KVLITG-LTEPRALALFPAKGYLYWSDWGEHPY------IERSYLDGSQRQIIVQVDLGF 1530
K L+ G ++ PR + + P G++YW+DW E IE++++DG RQI V + +
Sbjct: 637 KTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLW 696
Query: 1531 PNGLTIDYKERRLYWTDALKDRIDTSDLNGQHR--VQLVPDAKNPFGMTQFKDYIYWTDW 1588
PNGLT+D+ LYW DA D I+ LNG HR V + +PFG++ +Y++WTD+
Sbjct: 697 PNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTDY 756
Query: 1589 YKKSIIRADKRTGKNITLIRTNLEMAMEIKAVSADRQHGWNPCKESNGGCSHLCLFRGHE 1648
SI + D T + +TL+R ++ +Q G N C+ +NGGCS LCL
Sbjct: 757 MNGSIFQLDLITSE-VTLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGG 815
Query: 1649 YICACPDD 1656
+CAC D+
Sbjct: 816 RVCACADN 823
Score = 254 bits (621), Expect = 3e-66
Identities = 229/825 (27%), Positives = 371/825 (44%), Gaps = 89/825 (10%)
Query: 304 CNAGEFKCNDG-KCIPERWRCDNERDCADGGDE-LNCKPNSIR-NCSLDEYTC-ADRRCV 359
C+ GEF C+D C+ + W CD + DC D DE L+ P + C L+ C +CV
Sbjct: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91
Query: 360 LKTWLCDGVRDCTNGEDE-MNC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKD 417
+ LC+GV DC +G DE ++C E+ Q C+ + ++ N+ R C + DG +
Sbjct: 92 HLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTR-C----YCEDGFEI 146
Query: 418 CPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYE 477
+D C + +C+ C + C T+ G C+C G+L+ D SC+ E +
Sbjct: 147 T---EDGRSCKDQDECAVYGTCSQTCRNTH-GSYTCSCVEGYLMQPDNRSCKAKIEPT-D 201
Query: 478 QDPVCSQTCSNTVGSF--------RCGCMTG-------YILRPDERSCKPTGESPTLLFS 522
+ P+ T+ F + G +I D + ES L
Sbjct: 202 RPPILLIANFETIEVFYLNGSKMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKC 261
Query: 523 NRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDV 582
+I + LT + +++++ HN + + + +++ ++ I V N +
Sbjct: 262 IQI-TKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTL 320
Query: 583 IRWGLETPAGVAVDWIHDLLFWTDSGT-RRVEVATLDGSKRAVLVANDLDKPRAIAVHPG 641
I L P +AVD I LF+TD G +VE +DG R ++ + ++P A+A+
Sbjct: 321 IDLELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLV 380
Query: 642 DALVFWTDWGPNPKIERADMDGDKRKTVIYD-EIFWPNGLTIDYTESKIYWADAKHHVIE 700
+ LV+W D + + D G R TVI ++ G+T+ E +Y ++ ++ I
Sbjct: 381 NKLVYWVDLYLD-YVGVVDYQGKNRHTVIQGRQVRHLYGITV--FEDYLYATNSDNYNIV 437
Query: 701 RA-AFDGRDRRKVTTKGLPHPFALTLFDDAIYWT-DWHTKSISTVNKNTGMG-------- 750
R F+G D + + + + + ++ T H + G
Sbjct: 438 RINRFNGTDIHSLIK--IENAWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSS 495
Query: 751 --IQTVHAGLNVPMDIHSRSCEETPEKLLL-YARRKDLRLKQLESKKPIDSLDMVIPVET 807
+T + RS + +L L Y + + ++ ++ I + +IP+E
Sbjct: 496 YKTRTCRCRTGFNLGSDGRSYKRPKNELFLFYGKGRPGIVRGMDLNTKIAD-EYMIPIEN 554
Query: 808 IKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIY 867
+ + ALD+ ++N I++ D I R ++G+ + TI+ +L G+A DWI + +Y
Sbjct: 555 LVNPRALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLY 614
Query: 868 WTDGG----TNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPC---- 919
WT+ G N + K+ S +TLL + + PR IVV+P G MYW+DW
Sbjct: 615 WTNDGHRKTINVARLEKASQSRKTLLEGE-MSHPRGIVVDPVNGWMYWTDWEEDEIDDSV 673
Query: 920 --IERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLI 977
IE+A MDG NR+ + +M WPNGL LD N +YW D IE L+GT R K++
Sbjct: 674 GRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHR-KIV 732
Query: 978 ---ENLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGA------------------KRRT 1016
L HPFGL +G+ VFWTD+ SI + T R+
Sbjct: 733 YSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDLITSEVTLLRHERPPLFGLQIYDPRKQ 792
Query: 1017 LG---CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGP 1058
G C NNGGCS LCL PGGR CAC L+++G TC P
Sbjct: 793 QGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNP 837
Score = 248 bits (607), Expect = 1e-64
Identities = 165/548 (30%), Positives = 265/548 (48%), Gaps = 47/548 (8%)
Query: 857 LAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGA 916
+A DW+T +Y+ D +RI V S+GS+ L + P+ I V+P G ++++D+G
Sbjct: 288 MAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGN 347
Query: 917 SPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKL 976
+ER DMDG NR ++I + P LALDLV+ +YW D + + G R +
Sbjct: 348 VAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGKNRHTV 407
Query: 977 IEN--LPHPFGLDLYGDEVFWTDWDTQS-----------------------IQAANKDTG 1011
I+ + H +G+ ++ D ++ T+ D + I+ K T
Sbjct: 408 IQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIKIENAWGIRIYQKRTQ 467
Query: 1012 AKRRTLGCGKNN----GGCSHLCLLKPG--GRSCACPIGIKLNKDGKTCADGPINYLIFA 1065
R+ C + GGCSH+CLL R+C C G L DG++ +F
Sbjct: 468 PTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSYKRPKNELFLFY 527
Query: 1066 HRVD---IRVISLDVPYLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLG 1122
+ +R + L+ + ++P+ L N +D T IY+ DT I R G
Sbjct: 528 GKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDG 587
Query: 1123 THVETVIGNGLHTADGIVIDSTGRKIYWT-DGGRNSIEVAELD--GRNRKVLVWTGLDSP 1179
T ET++ + L +GI +D G +YWT DG R +I VA L+ ++RK L+ + P
Sbjct: 588 TERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHP 647
Query: 1180 RAIALHYEYGYMFWSDW------GTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEG 1233
R I + G+M+W+DW + +IE+A MDG NR++ V +K+ WPNGL +D
Sbjct: 648 RGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTN 707
Query: 1234 RLYWNDAKILTIESSDFDGHDRRTVLS--NVPYPYGIVIVGQHIYWTDWKTKALHRADKT 1291
LYW DA IE +G R+ V S + +P+G+ G +++WTD+ ++ + D
Sbjct: 708 TLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDLI 767
Query: 1292 NASDPIVIRKNLEGLMDIRAIQSERVL-ENACGTDNGGCSHLCLRSPLGYTCACPTGMPF 1350
S+ ++R L ++ + +N C +NGGCS LCL P G CAC
Sbjct: 768 -TSEVTLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLL 826
Query: 1351 EKSTTDQT 1358
+++ T T
Sbjct: 827 DENGTTCT 834
Score = 56.0 bits (129), Expect = 1e-06
Identities = 51/163 (31%), Positives = 74/163 (45%), Gaps = 21/163 (12%)
Query: 263 CAEIDFECKN-TKCVPKDFQCDGDNDCGDWTDE--DSCP-MVPGSCNAGEFKC-NDGKCI 317
C +F C + CV + + CDGD DC D +DE D+CP V C C KC+
Sbjct: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91
Query: 318 PERWRCDNERDCADGGDE-LNCKPNSIRNC-SLD-EYTCADRRCVLKTWLCDGVRDCTNG 374
C+ DC DG DE ++C+ + NC L+ +Y C R + + DG +G
Sbjct: 92 HLSQLCNGVLDCPDGYDEGVHCQ-ELLSNCQQLNCQYKCTMVRNSTRCYCEDGFEITEDG 150
Query: 375 ---EDEMNCEV--SCEE------DQYTCRPQE-HLMSNAFRNC 405
+D+ C V +C + YTC E +LM R+C
Sbjct: 151 RSCKDQDECAVYGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSC 193
Score = 55.2 bits (127), Expect = 2e-06
Identities = 21/41 (51%), Positives = 27/41 (65%), Gaps = 2/41 (4%)
Query: 300 VPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDE--LNC 338
+P C AGEF+C + CI RW+CD + DC DG DE +NC
Sbjct: 841 LPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNC 881
Score = 47.2 bits (107), Expect = 5e-04
Identities = 23/59 (38%), Positives = 31/59 (52%), Gaps = 1/59 (1%)
Query: 239 CAKKALDNAANPRSTWNQPVELMR-CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDS 296
CA L + T+N L C +F CKN C+ ++CDGD+DC D +DEDS
Sbjct: 820 CADNQLLDENGTTCTFNPGEALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDS 878
Score = 43.6 bits (98), Expect = 0.007
Identities = 18/35 (51%), Positives = 21/35 (60%), Gaps = 2/35 (5%)
Query: 158 CDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDE 192
CD E +CH C++ WLCDGD DC D SDE
Sbjct: 32 CDPGE--FLCHDHVTCVSQSWLCDGDPDCPDDSDE 64
Score = 42.7 bits (96), Expect = 0.012
Identities = 16/37 (43%), Positives = 21/37 (56%), Gaps = 2/37 (5%)
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCTNG--EDEMNC 380
C E+ C +R C+ W CDG DC +G ED +NC
Sbjct: 845 CKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNC 881
Score = 37.1 bits (82), Expect = 0.57
Identities = 15/25 (60%), Positives = 17/25 (68%), Gaps = 2/25 (8%)
Query: 173 CIALEWLCDGDNDCGDFSDE--INC 195
CI W CDGD+DC D SDE +NC
Sbjct: 857 CIQARWKCDGDDDCLDGSDEDSVNC 881
Score = 33.1 bits (72), Expect = 9.3
Identities = 15/34 (44%), Positives = 19/34 (55%), Gaps = 1/34 (2%)
Query: 163 NRTICHSTNVCIALEWLCDGDNDCGDFSDE-INC 195
N C TN C+ L LC+G DC D DE ++C
Sbjct: 80 NHIACLGTNKCVHLSQLCNGVLDCPDGYDEGVHC 113
>AC073319-1|AAX93075.1| 585|Homo sapiens unknown protein.
Length = 585
Score = 276 bits (677), Expect = 5e-73
Identities = 162/488 (33%), Positives = 259/488 (53%), Gaps = 26/488 (5%)
Query: 1191 MFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDF 1250
+F++D+G AK+ER DMDG NR I+D+K + P LA+D + +YW D + + D+
Sbjct: 2 LFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDY 61
Query: 1251 DGHDRRTVLS--NVPYPYGIVIVGQHIYWTDWKTKALHRADKTNASD--PIVIRKNLEGL 1306
G +R TV+ V + YGI + ++Y T+ + R ++ N +D ++ +N G+
Sbjct: 62 QGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIKIENAWGI 121
Query: 1307 MDIRAIQSERVLENACGTD----NGGCSHLCLRSP--LGYTCACPTGMPFEKSTTDQTPK 1360
+ V +AC D GGCSH+CL S TC C TG F + ++ K
Sbjct: 122 RIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTG--FNLGSDGRSCK 179
Query: 1361 KCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDL 1420
+ K+ F G + + L + + +P++ + N A+D+H + I++ D
Sbjct: 180 RPKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTS 239
Query: 1421 NVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEH-KVIEVARLD--GSSR 1477
+I + +E +TI+ L+ G+ VDWI NN+YWT++ H K I VARL+ SR
Sbjct: 240 FLIGRQKIDG-TERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSR 298
Query: 1478 KVLITG-LTEPRALALFPAKGYLYWSDWGEHPY------IERSYLDGSQRQIIVQVDLGF 1530
K L+ G ++ PR + + P G++YW+DW E IE++++DG RQI V + +
Sbjct: 299 KTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLW 358
Query: 1531 PNGLTIDYKERRLYWTDALKDRIDTSDLNGQHR--VQLVPDAKNPFGMTQFKDYIYWTDW 1588
PNGLT+D+ LYW DA D I+ LNG HR V + +PFG++ +Y++WTD+
Sbjct: 359 PNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTDY 418
Query: 1589 YKKSIIRADKRTGKNITLIRTNLEMAMEIKAVSADRQHGWNPCKESNGGCSHLCLFRGHE 1648
SI + D T + +TL+R ++ +Q G N C+ +NGGCS LCL
Sbjct: 419 MNGSIFQLDLITSE-VTLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGG 477
Query: 1649 YICACPDD 1656
+CAC D+
Sbjct: 478 RVCACADN 485
Score = 221 bits (539), Expect = 2e-56
Identities = 148/496 (29%), Positives = 238/496 (47%), Gaps = 47/496 (9%)
Query: 909 MYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANL 968
++++D+G +ER DMDG NR ++I + P LALDLV+ +YW D + +
Sbjct: 2 LFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDY 61
Query: 969 DGTGRTKLIEN--LPHPFGLDLYGDEVFWTDWDTQS-----------------------I 1003
G R +I+ + H +G+ ++ D ++ T+ D + I
Sbjct: 62 QGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIKIENAWGI 121
Query: 1004 QAANKDTGAKRRTLGCGKNN----GGCSHLCLLKPG--GRSCACPIGIKLNKDGKTCADG 1057
+ K T R+ C + GGCSH+CLL R+C C G L DG++C
Sbjct: 122 RIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRP 181
Query: 1058 PINYLIFAHRVD---IRVISLDVPYLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRK 1114
+F + +R + L+ + ++P+ L N +D T IY+ DT
Sbjct: 182 KNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFL 241
Query: 1115 IQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWT-DGGRNSIEVAELD--GRNRKVL 1171
I R GT ET++ + L +GI +D G +YWT DG R +I VA L+ ++RK L
Sbjct: 242 IGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTL 301
Query: 1172 VWTGLDSPRAIALHYEYGYMFWSDW------GTSAKIERADMDGNNRRVIVDNKIKWPNG 1225
+ + PR I + G+M+W+DW + +IE+A MDG NR++ V +K+ WPNG
Sbjct: 302 LEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNG 361
Query: 1226 LAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLS--NVPYPYGIVIVGQHIYWTDWKTK 1283
L +D LYW DA IE +G R+ V S + +P+G+ G +++WTD+
Sbjct: 362 LTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMNG 421
Query: 1284 ALHRADKTNASDPIVIRKNLEGLMDIRAIQSERVL-ENACGTDNGGCSHLCLRSPLGYTC 1342
++ + D S+ ++R L ++ + +N C +NGGCS LCL P G C
Sbjct: 422 SIFQLDLI-TSEVTLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGGRVC 480
Query: 1343 ACPTGMPFEKSTTDQT 1358
AC +++ T T
Sbjct: 481 ACADNQLLDENGTTCT 496
Score = 187 bits (456), Expect = 3e-46
Identities = 151/506 (29%), Positives = 236/506 (46%), Gaps = 57/506 (11%)
Query: 602 LFWTDSGT-RRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERAD 660
LF+TD G +VE +DG R ++ + ++P A+A+ + LV+W D + + D
Sbjct: 2 LFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLD-YVGVVD 60
Query: 661 MDGDKRKTVIYD-EIFWPNGLTIDYTESKIYWADAKHHVIERA-AFDGRDRRKVTTKGLP 718
G R TVI ++ G+T+ E +Y ++ ++ I R F+G D + +
Sbjct: 61 YQGKNRHTVIQGRQVRHLYGITV--FEDYLYATNSDNYNIVRINRFNGTDIHSLIK--IE 116
Query: 719 HPFALTLFDDAIYWT-DWHTKSISTVNKNTGMG----------IQTVHAGLNVPMDIHSR 767
+ + + ++ T H + G +T + R
Sbjct: 117 NAWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGR 176
Query: 768 SCEETPEKLLL-YARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWT 826
SC+ +L L Y + + ++ ++ I + +IP+E + + ALD+ ++N I++
Sbjct: 177 SCKRPKNELFLFYGKGRPGIVRGMDLNTKIAD-EYMIPIENLVNPRALDFHAETNYIYFA 235
Query: 827 DVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGG----TNRIEVSKSD 882
D I R ++G+ + TI+ +L G+A DWI + +YWT+ G N + K+
Sbjct: 236 DTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKAS 295
Query: 883 GSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPC------IERADMDGGNRKKLIFG 936
S +TLL + + PR IVV+P G MYW+DW IE+A MDG NR+ +
Sbjct: 296 QSRKTLLEGE-MSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTS 354
Query: 937 QMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLI---ENLPHPFGLDLYGDEV 993
+M WPNGL LD N +YW D IE L+GT R K++ L HPFGL +G+ V
Sbjct: 355 KMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHR-KIVYSGRELNHPFGLSHHGNYV 413
Query: 994 FWTDWDTQSIQAANKDTGA------------------KRRTLG---CGKNNGGCSHLCLL 1032
FWTD+ SI + T R+ G C NNGGCS LCL
Sbjct: 414 FWTDYMNGSIFQLDLITSEVTLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCLA 473
Query: 1033 KPGGRSCACPIGIKLNKDGKTCADGP 1058
PGGR CAC L+++G TC P
Sbjct: 474 IPGGRVCACADNQLLDENGTTCTFNP 499
Score = 155 bits (375), Expect = 2e-36
Identities = 91/276 (32%), Positives = 147/276 (53%), Gaps = 17/276 (6%)
Query: 482 CSQTC--SNTVGSFRCGCMTGYILRPDERSCK-PTGESPTLLFSNRIGI-RQVWLT---G 534
CS C S++ + C C TG+ L D RSCK P E R GI R + L
Sbjct: 148 CSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRPKNELFLFYGKGRPGIVRGMDLNTKIA 207
Query: 535 DNYMSVVKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVA 594
D YM ++ L N ALD+H E +++++ +I +++ +++ L+ G+A
Sbjct: 208 DEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIA 267
Query: 595 VDWIHDLLFWTDSGTRR-VEVATLD--GSKRAVLVANDLDKPRAIAVHPGDALVFWTDWG 651
VDWI + L+WT+ G R+ + VA L+ R L+ ++ PR I V P + ++WTDW
Sbjct: 268 VDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWE 327
Query: 652 PNP------KIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFD 705
+ +IE+A MDG R+ + ++ WPNGLT+D+ + +YW DA + IE+ +
Sbjct: 328 EDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLN 387
Query: 706 GRDRRKV-TTKGLPHPFALTLFDDAIYWTDWHTKSI 740
G R+ V + + L HPF L+ + ++WTD+ SI
Sbjct: 388 GTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMNGSI 423
Score = 94.3 bits (224), Expect = 4e-18
Identities = 39/82 (47%), Positives = 51/82 (62%), Gaps = 5/82 (6%)
Query: 300 VPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDE--LNCKPNSIRNCSLDEYTCADRR 357
+P C AGEF+C + CI RW+CD + DC DG DE +NC +S C D++ C + R
Sbjct: 503 LPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHS---CPDDQFKCQNNR 559
Query: 358 CVLKTWLCDGVRDCTNGEDEMN 379
C+ K WLCDG DC + EDE N
Sbjct: 560 CIPKRWLCDGANDCGSNEDESN 581
Score = 87.8 bits (208), Expect = 3e-16
Identities = 40/100 (40%), Positives = 52/100 (52%), Gaps = 1/100 (1%)
Query: 239 CAKKALDNAANPRSTWNQPVELMR-CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSC 297
CA L + T+N L C +F CKN C+ ++CDGD+DC D +DEDS
Sbjct: 482 CADNQLLDENGTTCTFNPGEALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSV 541
Query: 298 PMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELN 337
SC +FKC + +CIP+RW CD DC DE N
Sbjct: 542 NCFNHSCPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESN 581
Score = 71.3 bits (167), Expect = 3e-11
Identities = 101/443 (22%), Positives = 182/443 (41%), Gaps = 46/443 (10%)
Query: 1147 KIYWTDGGRNS-IEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERA 1205
K+++TD G + +E ++DG NR ++ + + P A+AL ++W D +
Sbjct: 1 KLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLD-YVGVV 59
Query: 1206 DMDGNNRRVIVDNK-IKWPNGLAIDRIEGRLY-WNDAKILTIESSDFDGHDRRTVLSNVP 1263
D G NR ++ + ++ G+ + E LY N + + F+G D +++ +
Sbjct: 60 DYQGKNRHTVIQGRQVRHLYGITV--FEDYLYATNSDNYNIVRINRFNGTDIHSLI-KIE 116
Query: 1264 YPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQSERVLENACG 1323
+GI IY +T+ R+ DP + + + + R G
Sbjct: 117 NAWGI-----RIY--QKRTQPTVRSHACEV-DPYGMPGGCSHICLLSSSYKTRTCRCRTG 168
Query: 1324 TDNGGCSHLCLRSP----LGYTCACP---TGMPFEKSTTDQ---------TPKKCKSHPE 1367
+ G C R L Y P GM D+ P+ H E
Sbjct: 169 FNLGSDGRSCKRPKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAE 228
Query: 1368 -EFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYT-DLDLNVIRS 1425
++ FA S + T+ ++ N + W +++T D I
Sbjct: 229 TNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINV 288
Query: 1426 INMTNMSES-KTIISQKLETPNGLGVDWIANNIYWTD-NEHKV------IEVARLDGSSR 1477
+ S+S KT++ ++ P G+ VD + +YWTD E ++ IE A +DG +R
Sbjct: 289 ARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNR 348
Query: 1478 KVLITG-LTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQ-VDLGFPNGLT 1535
++ +T + P L L LYW D + +IE+ +L+G+ R+I+ +L P GL+
Sbjct: 349 QIFVTSKMLWPNGLTLDFHTNTLYWCD-AYYDHIEKVFLNGTHRKIVYSGRELNHPFGLS 407
Query: 1536 IDYKERRLYWTDALKDRIDTSDL 1558
+ ++WTD + I DL
Sbjct: 408 --HHGNYVFWTDYMNGSIFQLDL 428
Score = 63.7 bits (148), Expect = 6e-09
Identities = 29/82 (35%), Positives = 42/82 (51%), Gaps = 12/82 (14%)
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDE--MNC-EVSCEEDQYTCRPQEHLMSNAF 402
C E+ C +R C+ W CDG DC +G DE +NC SC +DQ+ C+
Sbjct: 507 CKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNR------- 559
Query: 403 RNCVNRKHVCDGMKDCPRGDDE 424
C+ ++ +CDG DC +DE
Sbjct: 560 --CIPKRWLCDGANDCGSNEDE 579
Score = 38.7 bits (86), Expect = 0.19
Identities = 15/24 (62%), Positives = 15/24 (62%)
Query: 171 NVCIALEWLCDGDNDCGDFSDEIN 194
N CI WLCDG NDCG DE N
Sbjct: 558 NRCIPKRWLCDGANDCGSNEDESN 581
Score = 37.1 bits (82), Expect = 0.57
Identities = 15/25 (60%), Positives = 17/25 (68%), Gaps = 2/25 (8%)
Query: 173 CIALEWLCDGDNDCGDFSDE--INC 195
CI W CDGD+DC D SDE +NC
Sbjct: 519 CIQARWKCDGDDDCLDGSDEDSVNC 543
Score = 36.3 bits (80), Expect = 1.00
Identities = 19/70 (27%), Positives = 32/70 (45%)
Query: 557 KLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVAT 616
KL F N+ + M+ N + +I E PA +A+D ++ L++W D V V
Sbjct: 1 KLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVD 60
Query: 617 LDGSKRAVLV 626
G R ++
Sbjct: 61 YQGKNRHTVI 70
>AC093039-1|AAX88911.1| 425|Homo sapiens unknown protein.
Length = 425
Score = 239 bits (586), Expect = 5e-62
Identities = 131/388 (33%), Positives = 205/388 (52%), Gaps = 19/388 (4%)
Query: 263 CAEIDFECKNTK-CVPKDFQCDGDNDCGDWTDE-DSCPMVPGS-CNAGEFKCNDGKCIPE 319
CA F C+ ++ CVP+ + CDG+ DC D +DE + P + C+ F C++ CIP+
Sbjct: 44 CAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPK 103
Query: 320 RWRCDNERDCADGGDEL-NCKPNSIRNCSLDEYTCADRRCVLKT-WLCDGVRDCTNGEDE 377
++ CD++ DC DG DE C R C +E++CAD RC+L T W CDG DC + DE
Sbjct: 104 QFVCDHDDDCGDGSDESPQC---GYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDE 160
Query: 378 MNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE 437
C+ + +C + N C+ +CD DC G DE C + S +
Sbjct: 161 APLNPKCKSAEQSCNSSFFMCKNG--RCIPSGGLCDNKDDCGDGSDERNCHINECLSKKV 218
Query: 438 K-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCG 496
C + C + C C GF L +D +C DIDEC CSQ C NT G+++C
Sbjct: 219 SGCSQDCQDLPVSYK-CKCWPGFQLKDDGKTCVDIDEC--SSGFPCSQQCINTYGTYKCL 275
Query: 497 CMTGYILRPDE-RSCKP-TGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHY 554
C GY ++PD CK + E P L+ ++ IR++ G NY + +GL+N +A+D+ Y
Sbjct: 276 CTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDY 335
Query: 555 EKKLVFWSENNL-RVIRVAQMNTKNMSDV-IRWGLETPAGVAVDWIHDLLFWTDSGTRRV 612
++ ++W +++ R+ +M N SD+ + P +AVDWI L+W+D+ R +
Sbjct: 336 REEFIYWIDSSRPNGSRINRM-CLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRII 394
Query: 613 EVATLDGSKRAVLVANDLDKPRAIAVHP 640
EV+ L+G +LV+ L PR +++ P
Sbjct: 395 EVSKLNGLYPTILVSKRLKFPRDLSLDP 422
Score = 159 bits (385), Expect = 1e-37
Identities = 123/441 (27%), Positives = 196/441 (44%), Gaps = 42/441 (9%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK-CIPERW 321
C+ F C KC+ K + CDG++DCGD DE +C A F C + C+P W
Sbjct: 3 CSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMFSCQGSRACVPRHW 62
Query: 322 RCDNERDCADGGDELN---CKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEM 378
CD ERDC DG DEL+ C PN+ C + + C ++ C+ K ++CD DC +G DE
Sbjct: 63 LCDGERDCPDGSDELSTAGCAPNN--TCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDE- 119
Query: 379 NCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKC-SAEE 437
C Q C +E ++ R +N + CDG DCP D + PL KC SAE+
Sbjct: 120 --SPQCGYRQ--CGTEEFSCADG-RCLLNTQWQCDGDFDCP--DHSDEAPLNPKCKSAEQ 172
Query: 438 KCEKLCITTYDGHAACACPMGFLLAEDKYSCRD--------IDECMYEQDPVCSQTCSNT 489
C +G P G L ++K C D I+EC+ ++ CSQ C +
Sbjct: 173 SCNSSFFMCKNGR---CIPSGG-LCDNKDDCGDGSDERNCHINECLSKKVSGCSQDCQDL 228
Query: 490 VGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQV----WLTGDNYMSVVKGLH 545
S++C C G+ L+ D ++C E + ++ I L D Y +
Sbjct: 229 PVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYKCLCTDGYEIQPDNPN 288
Query: 546 NAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWT 605
+L E L+ + +R I N +++ GL + D+ + ++W
Sbjct: 289 GCKSLS-DEEPFLILADHHEIRKISTDGSN----YTLLKQGLNNVIAIDFDYREEFIYWI 343
Query: 606 DSGT---RRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMD 662
DS R+ L+GS + V ++ P A+AV ++W+D IE + ++
Sbjct: 344 DSSRPNGSRINRMCLNGSD--IKVVHNTAVPNALAVDWIGKNLYWSD-TEKRIIEVSKLN 400
Query: 663 GDKRKTVIYDEIFWPNGLTID 683
G ++ + +P L++D
Sbjct: 401 GLYPTILVSKRLKFPRDLSLD 421
Score = 101 bits (241), Expect = 3e-20
Identities = 52/136 (38%), Positives = 72/136 (52%), Gaps = 6/136 (4%)
Query: 303 SCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTC-ADRRCVLK 361
SC+ +F C+ KCI + W CD E DC DG DE + +I C+ D ++C R CV +
Sbjct: 2 SCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAI-TCAADMFSCQGSRACVPR 60
Query: 362 TWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRG 421
WLCDG RDC +G DE++ C + TC + N + C+ ++ VCD DC G
Sbjct: 61 HWLCDGERDCPDGSDELS-TAGCAPNN-TCDENAFMCHN--KVCIPKQFVCDHDDDCGDG 116
Query: 422 DDEERCPLKRKCSAEE 437
DE R+C EE
Sbjct: 117 SDESPQCGYRQCGTEE 132
Score = 95.5 bits (227), Expect = 2e-18
Identities = 58/180 (32%), Positives = 84/180 (46%), Gaps = 24/180 (13%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIAL 226
C + C+ WLCDG+ DC D SDE++ T+ P+ N + + V I
Sbjct: 51 CQGSRACVPRHWLCDGERDCPDGSDELS-----TAGCAPNNTCDENA--FMCHNKVCIP- 102
Query: 227 TKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPK-DFQCDGD 285
V ++ C + ++ P+ + Q C +F C + +C+ +QCDGD
Sbjct: 103 --KQFVCDHDDDCGDGSDES---PQCGYRQ------CGTEEFSCADGRCLLNTQWQCDGD 151
Query: 286 NDCGDWTDE----DSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPN 341
DC D +DE C SCN+ F C +G+CIP CDN+ DC DG DE NC N
Sbjct: 152 FDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHIN 211
Score = 86.2 bits (204), Expect = 9e-16
Identities = 55/172 (31%), Positives = 83/172 (48%), Gaps = 10/172 (5%)
Query: 1329 CSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEE--FLIFATRGSITYISLESP 1386
CS C+ + Y C C G + P CKS +E FLI A I IS +
Sbjct: 261 CSQQCINTYGTYKCLCTDGYEIQPDN----PNGCKSLSDEEPFLILADHHEIRKISTDGS 316
Query: 1387 EQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPN 1446
+ TL + + N IA+D+ + + I++ D IN ++ S + PN
Sbjct: 317 ---NYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAVPN 373
Query: 1447 GLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLIT-GLTEPRALALFPAKG 1497
L VDWI N+YW+D E ++IEV++L+G +L++ L PR L+L P G
Sbjct: 374 ALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAG 425
Score = 68.5 bits (160), Expect = 2e-10
Identities = 37/114 (32%), Positives = 58/114 (50%), Gaps = 5/114 (4%)
Query: 797 DSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDT---INRAYLNGSHQTTIVDSNLIW 853
D + + + + + +A+D+D + I+W D + INR LNGS + N
Sbjct: 314 DGSNYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVV--HNTAV 371
Query: 854 PAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGG 907
P LA DWI +YW+D IEVSK +G T+L + PRD+ ++P+ G
Sbjct: 372 PNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAG 425
Score = 67.7 bits (158), Expect = 4e-10
Identities = 49/171 (28%), Positives = 80/171 (46%), Gaps = 13/171 (7%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDG----KTCADGPINYLIFAHRVDIRVISLDVPYLI 1081
CS C+ G C C G ++ D K+ +D +LI A +IR IS D
Sbjct: 261 CSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLSDEE-PFLILADHHEIRKISTDGS--- 316
Query: 1082 DVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRL---GTHVETVIGNGLHTADG 1138
+ L L N + +D D+ IYW D+ + R R+ G+ ++ V + A
Sbjct: 317 NYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAVPNA-- 374
Query: 1139 IVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYG 1189
+ +D G+ +YW+D + IEV++L+G +LV L PR ++L + G
Sbjct: 375 LAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAG 425
Score = 51.2 bits (117), Expect = 3e-05
Identities = 57/215 (26%), Positives = 90/215 (41%), Gaps = 15/215 (6%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPY- 1079
K GCS C P C C G +L DGKTC D I+ + I+ Y
Sbjct: 216 KKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVD--IDECSSGFPCSQQCINTYGTYK 273
Query: 1080 --LIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTAD 1137
D P N D LI +I++ + G++ T++ GL+
Sbjct: 274 CLCTDGYEIQPDNPNGCKSLSDEEPFLIL---ADHHEIRKISTDGSNY-TLLKQGLNNVI 329
Query: 1138 GIVIDSTGRKIYWTDGGR---NSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWS 1194
I D IYW D R + I L+G + KV+ T + P A+A+ + ++WS
Sbjct: 330 AIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAV--PNALAVDWIGKNLYWS 387
Query: 1195 DWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAID 1229
D IE + ++G ++V ++K+P L++D
Sbjct: 388 D-TEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLD 421
Score = 50.4 bits (115), Expect = 6e-05
Identities = 37/113 (32%), Positives = 51/113 (45%), Gaps = 12/113 (10%)
Query: 88 SLQKAID---VIHTDPDDGPLNEGTEDDAGCITPCLKINFSCQISCTCIPME-----KRX 139
S QK I + + D G + ++ G IT C FSCQ S C+P +R
Sbjct: 11 SAQKCISKHWICDGEDDCGDGLDESDSICGAIT-CAADMFSCQGSRACVPRHWLCDGERD 69
Query: 140 XXXXXXXXXXXXXXXXRSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDE 192
+CDE N +CH+ VCI +++CD D+DCGD SDE
Sbjct: 70 CPDGSDELSTAGCAPNNTCDE--NAFMCHN-KVCIPKQFVCDHDDDCGDGSDE 119
Score = 50.4 bits (115), Expect = 6e-05
Identities = 33/107 (30%), Positives = 51/107 (47%), Gaps = 4/107 (3%)
Query: 1463 EHKVIEVARLDGSSRKVLITGLTEPRALALFPAKGYLYWSDWGEH--PYIERSYLDGSQR 1520
+H I DGS+ +L GL A+ + ++YW D I R L+GS
Sbjct: 304 DHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDI 363
Query: 1521 QIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQLV 1567
+++ + PN L +D+ + LYW+D K I+ S LNG + LV
Sbjct: 364 KVVHNTAV--PNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILV 408
Score = 47.2 bits (107), Expect = 5e-04
Identities = 30/99 (30%), Positives = 51/99 (51%), Gaps = 5/99 (5%)
Query: 1156 NSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWG--TSAKIERADMDGNNRR 1213
+ I DG N +L GL++ AI Y +++W D ++I R ++G++ +
Sbjct: 306 HEIRKISTDGSNYTLLK-QGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIK 364
Query: 1214 VIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDG 1252
V+ + + PN LA+D I LYW+D + IE S +G
Sbjct: 365 VVHNTAV--PNALAVDWIGKNLYWSDTEKRIIEVSKLNG 401
Score = 44.0 bits (99), Expect = 0.005
Identities = 36/105 (34%), Positives = 48/105 (45%), Gaps = 5/105 (4%)
Query: 1436 TIISQKLETPNGLGVDWIANNIYWTDNEH---KVIEVARLDGSSRKVLITGLTEPRALAL 1492
T++ Q L + D+ IYW D+ I L+GS KV + P ALA+
Sbjct: 319 TLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKV-VHNTAVPNALAV 377
Query: 1493 FPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTID 1537
LYWSD E IE S L+G I+V L FP L++D
Sbjct: 378 DWIGKNLYWSDT-EKRIIEVSKLNGLYPTILVSKRLKFPRDLSLD 421
Score = 41.9 bits (94), Expect = 0.020
Identities = 31/110 (28%), Positives = 51/110 (46%), Gaps = 5/110 (4%)
Query: 618 DGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWG-PN-PKIERADMDGDKRKTVIYDEIF 675
DGS +L L+ AI + ++W D PN +I R ++G K V +
Sbjct: 314 DGSNYTLL-KQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAV- 371
Query: 676 WPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTL 725
PN L +D+ +YW+D + +IE + +G + +K L P L+L
Sbjct: 372 -PNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSL 420
Score = 38.7 bits (86), Expect = 0.19
Identities = 15/30 (50%), Positives = 20/30 (66%), Gaps = 1/30 (3%)
Query: 163 NRTICHSTNVCIALEWLCDGDNDCGDFSDE 192
N+ C S CI+ W+CDG++DCGD DE
Sbjct: 6 NQFAC-SAQKCISKHWICDGEDDCGDGLDE 34
Score = 37.1 bits (82), Expect = 0.57
Identities = 22/73 (30%), Positives = 33/73 (45%), Gaps = 4/73 (5%)
Query: 680 LTIDYTESKIYWADAKH---HVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWH 736
+ DY E IYW D+ I R +G D + V +P+ A+ +YW+D
Sbjct: 331 IDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTE 390
Query: 737 TKSISTVNKNTGM 749
K I V+K G+
Sbjct: 391 -KRIIEVSKLNGL 402
Score = 36.7 bits (81), Expect = 0.76
Identities = 33/118 (27%), Positives = 52/118 (44%), Gaps = 6/118 (5%)
Query: 874 NRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGA--SPCIERADMDGGNRK 931
+ I +DGS TLL ++ I + +YW D I R ++G + K
Sbjct: 306 HEIRKISTDGSNYTLLK-QGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIK 364
Query: 932 KLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLI-ENLPHPFGLDL 988
+ PN LA+D + +YW+D + IE + L+G T L+ + L P L L
Sbjct: 365 --VVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSL 420
>AB209707-1|BAD92944.1| 1720|Homo sapiens low density
lipoprotein-related protein 1B variant protein.
Length = 1720
Score = 232 bits (567), Expect = 1e-59
Identities = 129/370 (34%), Positives = 194/370 (52%), Gaps = 13/370 (3%)
Query: 384 CEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEK-CEKL 442
C+ + +C + N C+ +CD DC G DE C + S + C +
Sbjct: 5 CKSAEQSCNSSFFMCKNG--RCIPSGGLCDNKDDCGDGSDERNCHINECLSKKVSGCSQD 62
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C + C C GF L +D +C DIDEC CSQ C NT G+++C C GY
Sbjct: 63 CQDLPVSYK-CKCWPGFQLKDDGKTCVDIDEC--SSGFPCSQQCINTYGTYKCLCTDGYE 119
Query: 503 LRPDE-RSCKP-TGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLVF 560
++PD CK + E P L+ ++ IR++ G NY + +GL+N +A+D+ Y ++ ++
Sbjct: 120 IQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYREEFIY 179
Query: 561 WSENNL-RVIRVAQMNTKNMSDV-IRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLD 618
W +++ R+ +M N SD+ + P +AVDWI L+W+D+ R +EV+ L+
Sbjct: 180 WIDSSRPNGSRINRM-CLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLN 238
Query: 619 GSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPN 678
G +LV+ L PR +++ P ++W D P I R MDG + VI +I P
Sbjct: 239 GLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPM 298
Query: 679 GLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWHTK 738
LTIDY ++YWAD H IE + DG R KV + +P ALTLF+D IYWTD TK
Sbjct: 299 ALTIDYVNRRLYWADENH--IEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTK 356
Query: 739 SISTVNKNTG 748
S+S +K +G
Sbjct: 357 SLSRAHKTSG 366
Score = 214 bits (522), Expect = 3e-54
Identities = 142/504 (28%), Positives = 222/504 (44%), Gaps = 41/504 (8%)
Query: 263 CAEIDFECKN-TKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
C E F CKN C+P + CDG +DC D +DE++C C A EF CN+ C W
Sbjct: 753 CKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHFW 812
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRR-CVLKTWLCDGVRDCTNGEDEMNC 380
CD E DC D DE S + C + R C+ +C+G+ +C + DE +C
Sbjct: 813 VCDGEDDCGDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHC 872
Query: 381 EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC---PLKRKCSAE- 436
C+ E SN + C+ CD + DC G DE+ C P + C
Sbjct: 873 GGKLTYKARPCKKDEFACSN--KKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNV 930
Query: 437 EKC-EKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRC 495
C + C C GF C D++EC+ CS C N GS++C
Sbjct: 931 NPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFG--TCSHQCINVEGSYKC 988
Query: 496 GCMTGYILRPDERSCKPTGESPTLLF----SNRIGIRQVWLTGDNYMSVVKGLHNA--VA 549
C + R +C G +L+ ++ +G + ++ + HN+
Sbjct: 989 VCDQNFQER--NNTCIAEGSEDQVLYIANDTDILGFIYPFNYSGDHQQISHIEHNSRITG 1046
Query: 550 LDYHYEKKLVFWSEN-NLRVIRVAQMNTKNM----SDVIRWGLETPAGVAVDWIHDLLFW 604
+D +Y++ ++ WS N I +++ + S +I + P +AVDW+ ++W
Sbjct: 1047 MDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFKRPRDIAVDWVAGNIYW 1106
Query: 605 TDSGTRR---------------VEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTD 649
TD + V L+G L+ N +P AIAV+P +++WT
Sbjct: 1107 TDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTV 1166
Query: 650 WGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDR 709
G + IE A MDG R+ ++ + P GL +DY +IYWAD + +I +DG +
Sbjct: 1167 VGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDGSNS 1226
Query: 710 -RKVTTK-GLPHPFALTLFDDAIY 731
V++K GL HP + +F+D IY
Sbjct: 1227 VVSVSSKQGLLHPHRIDIFEDYIY 1250
Score = 203 bits (496), Expect = 4e-51
Identities = 119/334 (35%), Positives = 177/334 (52%), Gaps = 18/334 (5%)
Query: 1329 CSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEE--FLIFATRGSITYISLESP 1386
CS C+ + Y C C G + P CKS +E FLI A I IS +
Sbjct: 99 CSQQCINTYGTYKCLCTDGYEIQPDN----PNGCKSLSDEEPFLILADHHEIRKISTDGS 154
Query: 1387 EQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPN 1446
+ TL + + N IA+D+ + + I++ D IN ++ S + PN
Sbjct: 155 ---NYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAVPN 211
Query: 1447 GLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITG-LTEPRALALFPAKGYLYWSDWG 1505
L VDWI N+YW+D E ++IEV++L+G +L++ L PR L+L P GYLYW D
Sbjct: 212 ALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCC 271
Query: 1506 EHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQ 1565
E+P+I R +DG+ + ++++ + P LTIDY RRLYW D ++ I+ S+++G HR
Sbjct: 272 EYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWAD--ENHIEFSNMDGSHR-H 328
Query: 1566 LVPDAKNP--FGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAVSAD 1623
VP+ P +T F+DYIYWTD KS+ RA K +G + + + +I+ +
Sbjct: 329 KVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSY 388
Query: 1624 RQHGWNP--CKESNGGCSHLCLFR-GHEYICACP 1654
RQ + C +NGGCSHLCL G + CACP
Sbjct: 389 RQPDVSKHLCMINNGGCSHLCLLAPGKTHTCACP 422
Score = 185 bits (450), Expect = 1e-45
Identities = 114/333 (34%), Positives = 172/333 (51%), Gaps = 20/333 (6%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDG----KTCADGPINYLIFAHRVDIRVISLDVPYLI 1081
CS C+ G C C G ++ D K+ +D +LI A +IR IS D
Sbjct: 99 CSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLSDEE-PFLILADHHEIRKISTDGS--- 154
Query: 1082 DVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRL---GTHVETVIGNGLHTADG 1138
+ L L N + +D D+ IYW D+ + R R+ G+ ++ V + A
Sbjct: 155 NYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAVPNA-- 212
Query: 1139 IVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGT 1198
+ +D G+ +YW+D + IEV++L+G +LV L PR ++L + GY++W D
Sbjct: 213 LAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCE 272
Query: 1199 SAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTV 1258
I R MDG N+ V+++ KI P L ID + RLYW D IE S+ DG R V
Sbjct: 273 YPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADEN--HIEFSNMDGSHRHKV 330
Query: 1259 LS-NVPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQSER- 1316
+ ++P + + +IYWTD KTK+L RA KT+ +D + + + + DI+ S R
Sbjct: 331 PNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQ 390
Query: 1317 --VLENACGTDNGGCSHLCLRSP-LGYTCACPT 1346
V ++ C +NGGCSHLCL +P +TCACPT
Sbjct: 391 PDVSKHLCMINNGGCSHLCLLAPGKTHTCACPT 423
Score = 169 bits (410), Expect = 1e-40
Identities = 100/287 (34%), Positives = 149/287 (51%), Gaps = 33/287 (11%)
Query: 797 DSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDT---INRAYLNGSHQTTIVDSNLIW 853
D + + + + + +A+D+D + I+W D + INR LNGS + N
Sbjct: 152 DGSNYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVV--HNTAV 209
Query: 854 PAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSD 913
P LA DWI +YW+D IEVSK +G T+L + PRD+ ++P+ G +YW D
Sbjct: 210 PNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWID 269
Query: 914 WGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGR 973
P I R MDG N+ +I +++ P L +D V+ R+YW D + IE++N+DG+ R
Sbjct: 270 CCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADENH--IEFSNMDGSHR 327
Query: 974 TKL-IENLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTL--------------- 1017
K+ +++P L L+ D ++WTD T+S+ A+K +GA R +L
Sbjct: 328 HKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHS 387
Query: 1018 ---------GCGKNNGGCSHLCLLKPG-GRSCACPIGIKLNKDGKTC 1054
C NNGGCSHLCLL PG +CACP L D +TC
Sbjct: 388 YRQPDVSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTC 434
Score = 163 bits (396), Expect = 5e-39
Identities = 83/218 (38%), Positives = 117/218 (53%), Gaps = 19/218 (8%)
Query: 263 CAEIDFECKNTK-CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
C+ F+CK TK C+ K + CD D DC D +DE +C +C EF+C + CIP+ W
Sbjct: 557 CSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKK--TCGPHEFQCKNNNCIPDHW 614
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCE 381
RCD++ DC+D DE NCKP + C+L ++ CA+ CV + CDG DC +G DE NCE
Sbjct: 615 RCDSQNDCSDNSDEENCKP---QTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNCE 671
Query: 382 VSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC-PLKRKCSAEEKCE 440
SC +DQ+ C SN C+ K CDG +DC G+DE+ C P CS+ E
Sbjct: 672 TSCSKDQFRC-------SNG--QCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSR---E 719
Query: 441 KLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQ 478
+C + A+ C + A+ + EC +Q
Sbjct: 720 YICASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQ 757
Score = 140 bits (340), Expect = 3e-32
Identities = 85/256 (33%), Positives = 118/256 (46%), Gaps = 31/256 (12%)
Query: 263 CAEIDFEC-KNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK-CIPER 320
C F+C KN KC+P + +C+G +DCGD DE CP SC+ F+C K CI +
Sbjct: 517 CLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCP--ENSCSPDYFQCKTTKHCISKL 574
Query: 321 WRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC 380
W CD + DCAD DE NC + C E+ C + C+ W CD DC++ DE NC
Sbjct: 575 WVCDEDPDCADASDEANCDK---KTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENC 631
Query: 381 EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE-KC 439
+ TC ++ L +N +CV+ + CDG DC G DE C + CS ++ +C
Sbjct: 632 K------PQTCTLKDFLCANG--DCVSSRFWCDGDFDCADGSDERNC--ETSCSKDQFRC 681
Query: 440 EK-LCITT---YDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC-SQTCSNTVGSFR 494
CI DGH C ED+ SC ++ +C S C + S +
Sbjct: 682 SNGQCIPAKWKCDGHEDCK------YGEDEKSCEPASPTCSSREYICASDGCIS--ASLK 733
Query: 495 CGCMTGYILRPDERSC 510
C DE C
Sbjct: 734 CNGEYDCADGSDEMDC 749
Score = 135 bits (327), Expect = 1e-30
Identities = 71/213 (33%), Positives = 102/213 (47%), Gaps = 24/213 (11%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C++ F C N +C+P ++CDG DC DE SC +C++ E+ C CI +
Sbjct: 674 CSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASDGCISASLK 733
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADR-RCVLKTWLCDGVRDCTNGEDEMNCE 381
C+ E DCADG DE++C + C D++ C ++ C+ WLCDG+ DC +G DE N
Sbjct: 734 CNGEYDCADGSDEMDC----VTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEEN-- 787
Query: 382 VSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEK 441
CE CR E L +N+ C VCDG DC GD+ + P + C K
Sbjct: 788 --CERGGNICRADEFLCNNSL--CKLHFWVCDGEDDC--GDNSDEAP--------DMCVK 833
Query: 442 LCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
+ H C + + + C IDEC
Sbjct: 834 FLCPSTRPH---RCRNNRICLQSEQMCNGIDEC 863
Score = 126 bits (303), Expect = 1e-27
Identities = 65/181 (35%), Positives = 89/181 (49%), Gaps = 17/181 (9%)
Query: 260 LMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDE-DSCPMVPGSCNAGEFKCNDGKCIP 318
L C F CK KC+P ++CD +DCGD +DE D CP C G F+C G C
Sbjct: 435 LSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEF--RCQPGRFQCGTGLCAL 492
Query: 319 ERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCA-DRRCVLKTWLCDGVRDCTNGEDE 377
+ CD E DC D DELNC + C ++ C +++C+ C+G DC + EDE
Sbjct: 493 PAFICDGENDCGDNSDELNCDTHV---CLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDE 549
Query: 378 MNC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAE 436
+C E SC D + C+ +H C+++ VCD DC DE C K+ C
Sbjct: 550 RDCPENSCSPDYFQCKTTKH--------CISKLWVCDEDPDCADASDEANCD-KKTCGPH 600
Query: 437 E 437
E
Sbjct: 601 E 601
Score = 111 bits (268), Expect = 2e-23
Identities = 91/356 (25%), Positives = 150/356 (42%), Gaps = 36/356 (10%)
Query: 1327 GGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSIT---YISL 1383
G CSH C+ Y C C +T + ++ L A I Y
Sbjct: 973 GTCSHQCINVEGSYKCVCDQNFQERNNTCI-----AEGSEDQVLYIANDTDILGFIYPFN 1027
Query: 1384 ESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFY-TDLDLNVI---RSINMTNMSESKTIIS 1439
S + ++ ++ +D ++ MI + T + I R + +I
Sbjct: 1028 YSGDHQQIS-HIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLIC 1086
Query: 1440 QKLETPNGLGVDWIANNIYWTDNEHK---------------VIEVARLDGSSRKVLITGL 1484
+ + P + VDW+A NIYWTD+ I V +L+G + L+T +
Sbjct: 1087 PEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNM 1146
Query: 1485 T-EPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRL 1543
EP A+A+ P +G +YW+ G+H +IE + +DG+ R+I+VQ +L P GL +DY R+
Sbjct: 1147 AGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERI 1206
Query: 1544 YWTDALKDRIDTSDLNGQHRVQLVPDAK---NPFGMTQFKDYIYWTDWYKKSIIRADKRT 1600
YW D I + +G + V V + +P + F+DYIY K + R K
Sbjct: 1207 YWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAG-PKNGVFRVQKFG 1265
Query: 1601 GKNITLIRTNLEMAMEIKAVSADRQHGW-NPCKESNGGCSHLCLFRGHEYICACPD 1655
++ + N++ + +Q NPC + C LCL C CP+
Sbjct: 1266 HGSVEYLALNIDKTKGVLISHRYKQLDLPNPCLDL--ACEFLCLLNPSGATCVCPE 1319
Score = 101 bits (243), Expect = 2e-20
Identities = 92/351 (26%), Positives = 146/351 (41%), Gaps = 30/351 (8%)
Query: 1024 GGCSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGPINYLIF-AHRVDIRVISLDVPYLI 1081
G CSH C+ G C C + + TC A+G + +++ A+ DI Y
Sbjct: 973 GTCSHQCINVEGSYKCVCDQNFQ--ERNNTCIAEGSEDQVLYIANDTDILGFIYPFNYSG 1030
Query: 1082 D--VVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTAD-- 1137
D + + G+DV + +I W+ R+ + +GL +
Sbjct: 1031 DHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFK 1090
Query: 1138 ---GIVIDSTGRKIYWTDGGRN---------------SIEVAELDGRNRKVLVWTGLDSP 1179
I +D IYWTD R SI V +L+G N L+ P
Sbjct: 1091 RPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEP 1150
Query: 1180 RAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND 1239
AIA++ + G M+W+ G + IE A MDG RR++V ++ P GLA+D R+YW D
Sbjct: 1151 YAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWAD 1210
Query: 1240 AKILTIESSDFDGHDRRTVLSN---VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDP 1296
++ I S +DG + +S+ + +P+ I I +IY K + R K
Sbjct: 1211 FELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPK-NGVFRVQKFGHGSV 1269
Query: 1297 IVIRKNLEGLMDIRAIQSERVLENACGTDNGGCSHLCLRSPLGYTCACPTG 1347
+ N++ + + L+ + C LCL +P G TC CP G
Sbjct: 1270 EYLALNIDKTKGVLISHRYKQLDLPNPCLDLACEFLCLLNPSGATCVCPEG 1320
Score = 97.9 bits (233), Expect = 3e-19
Identities = 63/214 (29%), Positives = 88/214 (41%), Gaps = 21/214 (9%)
Query: 303 SCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKT 362
+C A +F+C KCIP W+CD DC DG DE + P C + C C L
Sbjct: 437 NCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEF--RCQPGRFQCGTGLCALPA 494
Query: 363 WLCDGVRDCTNGEDEMNCEVS-CEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRG 421
++CDG DC + DE+NC+ C Q+ C + C+ C+G DC
Sbjct: 495 FICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQ--------KCIPVNLRCNGQDDCGDE 546
Query: 422 DDEERCPLKRKCSAEE---KCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQ 478
+DE CP + CS + K K CI+ C A D+ +C D C +
Sbjct: 547 EDERDCP-ENSCSPDYFQCKTTKHCISKL---WVCDEDPDCADASDEANC-DKKTCGPHE 601
Query: 479 DPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP 512
+ C +RC DE +CKP
Sbjct: 602 FQCKNNNC--IPDHWRCDSQNDCSDNSDEENCKP 633
Score = 90.2 bits (214), Expect = 6e-17
Identities = 89/386 (23%), Positives = 167/386 (43%), Gaps = 35/386 (9%)
Query: 338 CKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHL 397
CK ++ ++C+ + C + RC+ LCD DC +G DE NC ++ C ++
Sbjct: 5 CK-SAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHIN------ECLSKK-- 55
Query: 398 MSNAFRNCVNR--KHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACAC 455
+S ++C + + C DD + C +CS+ C + CI TY G C C
Sbjct: 56 VSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTY-GTYKCLC 114
Query: 456 PMGFLLAEDK-YSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTG 514
G+ + D C+ + +++P + + +L+ +
Sbjct: 115 TDGYEIQPDNPNGCKSLS----DEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAID 170
Query: 515 -----ESPTLLFSNRIG---IRQVWLTGDNYMSVVK-GLHNAVALDYHYEKKLVFWSENN 565
E + S+R I ++ L G + V + NA+A+D + K ++WS+
Sbjct: 171 FDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAVPNALAVD--WIGKNLYWSDTE 228
Query: 566 LRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTD-SGTRRVEVATLDGSKRAV 624
R+I V+++N + ++ L+ P +++D L+W D + +DG+ ++V
Sbjct: 229 KRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSV 288
Query: 625 LVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDY 684
++ + +P A+ + + ++W D IE ++MDG R V +I P + +
Sbjct: 289 VIETKISRPMALTIDYVNRRLYWAD---ENHIEFSNMDGSHRHKVPNQDI--PGVIALTL 343
Query: 685 TESKIYWADAKHHVIERA-AFDGRDR 709
E IYW D K + RA G DR
Sbjct: 344 FEDYIYWTDGKTKSLSRAHKTSGADR 369
Score = 89.4 bits (212), Expect = 1e-16
Identities = 104/403 (25%), Positives = 155/403 (38%), Gaps = 72/403 (17%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
++C HE + C + N CI W CD NDC D SDE NC +T L A+ GD
Sbjct: 595 KTCGPHEFQ--CKNNN-CIPDHWRCDSQNDCSDNSDEENCK-PQTCTLKDFLCAN---GD 647
Query: 216 VITNPTVL---IALTKPTVVIRYESFCAKKAL--DNAANPRSTWN-QPVELMRCAEIDFE 269
+++ + E+ C+K N + W E + E +
Sbjct: 648 CVSSRFWCDGDFDCADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKS 707
Query: 270 CK--NTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDG--------KCIPE 319
C+ + C +++ C D C CN GE+ C DG +C +
Sbjct: 708 CEPASPTCSSREYICASD----------GCISASLKCN-GEYDCADGSDEMDCVTECKED 756
Query: 320 RWRCDNE-------------RDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCD 366
++RC N+ DC DG DE NC+ C DE+ C + C L W+CD
Sbjct: 757 QFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGG-NICRADEFLCNNSLCKLHFWVCD 815
Query: 367 GVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEER 426
G DC + DE C ++ C R C+ + +C+G+ +C DE+
Sbjct: 816 GEDDCGDNSDE--APDMCV--KFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDH 871
Query: 427 CPLK-----RKCSAEE-KC-EKLCI------TTYDGHAACACPMGFLLAEDKYSCRD-ID 472
C K R C +E C K CI D + G +A +Y+C D ++
Sbjct: 872 CGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVN 931
Query: 473 ECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C D C+Q + S C C G+ R C+ E
Sbjct: 932 PC--GDDAYCNQIKT----SVFCRCKPGFQRNMKNRQCEDLNE 968
Score = 81.0 bits (191), Expect = 4e-14
Identities = 70/241 (29%), Positives = 96/241 (39%), Gaps = 40/241 (16%)
Query: 854 PAGLAFDWITDKIYWTDGGTNR---------------IEVSKSDGSMRTLLAWDHIDKPR 898
P +A DW+ IYWTD I V + +G T L + +P
Sbjct: 1092 PRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPY 1151
Query: 899 DIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDG 958
I VNP+ G+MYW+ G IE A MDG R+ L+ + P GLA+D RIYW D
Sbjct: 1152 AIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADF 1211
Query: 959 GNKTIEYANLDGTGRTKLI---ENLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGA-KR 1014
I DG+ + + L HP +D++ D ++ + G+ +
Sbjct: 1212 ELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKNGVFRVQKFGHGSVEY 1271
Query: 1015 RTLGCGKNNG-------------------GCSHLCLLKPGGRSCACPIGIKLNKDGKTCA 1055
L K G C LCLL P G +C CP G K +G TC
Sbjct: 1272 LALNIDKTKGVLISHRYKQLDLPNPCLDLACEFLCLLNPSGATCVCPEG-KYLING-TCN 1329
Query: 1056 D 1056
D
Sbjct: 1330 D 1330
Score = 79.0 bits (186), Expect = 1e-13
Identities = 74/287 (25%), Positives = 107/287 (37%), Gaps = 36/287 (12%)
Query: 111 DDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTICHST 170
D+ C+T C + F C+ CIP+ R + +
Sbjct: 745 DEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNN 804
Query: 171 NVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPT 230
++C W+CDG++DCGD SDE VK L PS T P
Sbjct: 805 SLCKLHFWVCDGEDDCGDNSDEAPDMCVK--FLCPS-----------TRPH---RCRNNR 848
Query: 231 VVIRYESFC--AKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDC 288
+ ++ E C + DN+ + C + +F C N KC+P D QCD +DC
Sbjct: 849 ICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDC 908
Query: 289 GDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDEL--NCKPNSIRNC 346
GD +DE C + P E+ C D P C ++ C + CKP RN
Sbjct: 909 GDGSDEQGCRIAP-----TEYTCED-NVNP----CGDDAYCNQIKTSVFCRCKPGFQRN- 957
Query: 347 SLDEYTCADRRCVLKTWLCDGVRDCTN--GEDEMNCEVSCEEDQYTC 391
+ C D L C C N G + C+ + +E TC
Sbjct: 958 -MKNRQCEDLNECLVFGTCS--HQCINVEGSYKCVCDQNFQERNNTC 1001
Score = 68.1 bits (159), Expect = 3e-10
Identities = 72/269 (26%), Positives = 114/269 (42%), Gaps = 19/269 (7%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPY- 1079
K GCS C P C C G +L DGKTC D I+ + I+ Y
Sbjct: 54 KKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVD--IDECSSGFPCSQQCINTYGTYK 111
Query: 1080 --LIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTAD 1137
D P N D LI +I++ + G++ T++ GL+
Sbjct: 112 CLCTDGYEIQPDNPNGCKSLSDEEPFLIL---ADHHEIRKISTDGSNY-TLLKQGLNNVI 167
Query: 1138 GIVIDSTGRKIYWTDGGR---NSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWS 1194
I D IYW D R + I L+G + KV+ T + P A+A+ + ++WS
Sbjct: 168 AIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAV--PNALAVDWIGKNLYWS 225
Query: 1195 DWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND-AKILTIESSDFDGH 1253
D IE + ++G ++V ++K+P L++D G LYW D + I DG
Sbjct: 226 D-TEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGT 284
Query: 1254 DRRTVL-SNVPYPYGIVI--VGQHIYWTD 1279
++ V+ + + P + I V + +YW D
Sbjct: 285 NQSVVIETKISRPMALTIDYVNRRLYWAD 313
Score = 59.3 bits (137), Expect = 1e-07
Identities = 54/217 (24%), Positives = 90/217 (41%), Gaps = 16/217 (7%)
Query: 680 LTIDYTESKIYWADAKH---HVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWH 736
+ DY E IYW D+ I R +G D + V +P+ A+ +YW+D
Sbjct: 169 IDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTE 228
Query: 737 TKSISTVNKNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESKKPI 796
+ I N V L P D+ P+ LY D + +
Sbjct: 229 KRIIEVSKLNGLYPTILVSKRLKFPRDL-----SLDPQAGYLY--WIDCCEYPHIGRVGM 281
Query: 797 DSLDMVIPVET-IKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPA 855
D + + +ET I +AL D + ++W D ++ I + ++GSH+ + + ++ P
Sbjct: 282 DGTNQSVVIETKISRPMALTIDYVNRRLYWAD--ENHIEFSNMDGSHRHKVPNQDI--PG 337
Query: 856 GLAFDWITDKIYWTDGGTNRI-EVSKSDGSMRTLLAW 891
+A D IYWTDG T + K+ G+ R L +
Sbjct: 338 VIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIY 374
Score = 56.8 bits (131), Expect = 7e-07
Identities = 22/45 (48%), Positives = 26/45 (57%)
Query: 297 CPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPN 341
C SCN+ F C +G+CIP CDN+ DC DG DE NC N
Sbjct: 5 CKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHIN 49
Score = 50.4 bits (115), Expect = 6e-05
Identities = 31/90 (34%), Positives = 39/90 (43%), Gaps = 8/90 (8%)
Query: 111 DDAGCITP-CLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHE---NRTI 166
D+ C T CL F C + CIP+ R R C E+ +
Sbjct: 508 DELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDE----RDCPENSCSPDYFQ 563
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCD 196
C +T CI+ W+CD D DC D SDE NCD
Sbjct: 564 CKTTKHCISKLWVCDEDPDCADASDEANCD 593
Score = 47.6 bits (108), Expect = 4e-04
Identities = 26/86 (30%), Positives = 36/86 (41%), Gaps = 2/86 (2%)
Query: 111 DDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTICHST 170
D+ C++ C F C+ CIP + R C T
Sbjct: 430 DNRTCLSNCTASQFRCKTD-KCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQC-GT 487
Query: 171 NVCIALEWLCDGDNDCGDFSDEINCD 196
+C ++CDG+NDCGD SDE+NCD
Sbjct: 488 GLCALPAFICDGENDCGDNSDELNCD 513
Score = 45.6 bits (103), Expect = 0.002
Identities = 33/131 (25%), Positives = 62/131 (47%), Gaps = 3/131 (2%)
Query: 825 WTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWT-DGGTNRIEVSKSDG 883
WT + + +IN LNG + T ++ + P +A + +YWT G + IE + DG
Sbjct: 1122 WTSL-RYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDG 1180
Query: 884 SMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNG 943
++R +L ++ +P + V+ +YW+D+ S I DG N + + +
Sbjct: 1181 TLRRILVQKNLQRPTGLAVDYFSERIYWADFELS-IIGSVLYDGSNSVVSVSSKQGLLHP 1239
Query: 944 LALDLVHNRIY 954
+D+ + IY
Sbjct: 1240 HRIDIFEDYIY 1250
Score = 44.0 bits (99), Expect = 0.005
Identities = 16/35 (45%), Positives = 21/35 (60%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSC 297
C F CKN +C+P CD +DCGD +DE +C
Sbjct: 12 CNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNC 46
Score = 43.6 bits (98), Expect = 0.007
Identities = 24/73 (32%), Positives = 39/73 (53%), Gaps = 1/73 (1%)
Query: 813 ALDWDQKSNSIFWTDV-EKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDG 871
A+ + K ++WT V + I A ++G+ + +V NL P GLA D+ +++IYW D
Sbjct: 1152 AIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADF 1211
Query: 872 GTNRIEVSKSDGS 884
+ I DGS
Sbjct: 1212 ELSIIGSVLYDGS 1224
Score = 39.5 bits (88), Expect = 0.11
Identities = 22/85 (25%), Positives = 36/85 (42%), Gaps = 1/85 (1%)
Query: 111 DDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTICHST 170
D+ C T C K F C + CIP + + + +R ++
Sbjct: 666 DERNCETSCSKDQFRCS-NGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICAS 724
Query: 171 NVCIALEWLCDGDNDCGDFSDEINC 195
+ CI+ C+G+ DC D SDE++C
Sbjct: 725 DGCISASLKCNGEYDCADGSDEMDC 749
Score = 35.5 bits (78), Expect = 1.7
Identities = 14/25 (56%), Positives = 16/25 (64%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDV 197
CI LCD +DCGD SDE NC +
Sbjct: 24 CIPSGGLCDNKDDCGDGSDERNCHI 48
>X04571-1|CAA28240.1| 1207|Homo sapiens protein ( Human mRNA for
kidney epidermal growth factor (EGF) precursor. ).
Length = 1207
Score = 229 bits (561), Expect = 5e-59
Identities = 119/338 (35%), Positives = 181/338 (53%), Gaps = 11/338 (3%)
Query: 418 CPRG----DDEERCPLKRKCSAE-EKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDID 472
CP G D +RC C +C C+ T +G C CP G +L D +C
Sbjct: 382 CPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEG-PLCFCPEGSVLERDGKTCSG-- 438
Query: 473 ECMYEQDPVCSQTCSN-TVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVW 531
C + CSQ C + S+ C C GY L+ DE+SC +G P LLF+N IR +
Sbjct: 439 -CSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMH 497
Query: 532 LTGDNYMSVVKGLHNAV-ALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETP 590
G +Y +++ V ALD+ + ++++ L+ I A M+ +I G++ P
Sbjct: 498 FDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVP 557
Query: 591 AGVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDW 650
G+AVDWI +WTD G + + L+G + ++ ++ +PR IAVHP +FWTD
Sbjct: 558 EGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDT 617
Query: 651 GPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRR 710
G NP+IE + + G R + ++ WP+G+TID+ K+YW DAK VIE A DG RR
Sbjct: 618 GINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRR 677
Query: 711 KVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTG 748
++T + HPFA+ +F+D ++++DW S+ VNK TG
Sbjct: 678 RLTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTG 715
Score = 199 bits (485), Expect = 8e-50
Identities = 111/333 (33%), Positives = 179/333 (53%), Gaps = 12/333 (3%)
Query: 1325 DNGGCSHLCLR-SPLGYTCACPTGMPFEKSTTDQTPKKCK-SHPEEFLIFATRGSITYIS 1382
DNGGCS LC+ SP+ + C C G + D+ K C S P+ FL+FA I ++
Sbjct: 443 DNGGCSQLCVPLSPVSWECDCFPGYDLQ---LDE--KSCAASGPQPFLLFANSQDIRHMH 497
Query: 1383 LESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKL 1442
+ + TL +++ A+D+ I++ L I NM S+ + +I + +
Sbjct: 498 FDGTDYG--TLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDG-SQRERLIEEGV 554
Query: 1443 ETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLIT-GLTEPRALALFPAKGYLYW 1501
+ P GL VDWI YWTD +I + L+G K++ +++PR +A+ P L+W
Sbjct: 555 DVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFW 614
Query: 1502 SDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQ 1561
+D G +P IE S L G R +I DL +P+G+TID+ +LYW DA + I+ ++L+G
Sbjct: 615 TDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGS 674
Query: 1562 HRVQLVP-DAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAV 1620
R +L D +PF + F+DY++++DW S+IR +KRTGK+ ++ ++ + V
Sbjct: 675 KRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVRLQGSMLKPSSLVVV 734
Query: 1621 SADRQHGWNPCKESNGGCSHLCLFRGHEYICAC 1653
+ G +PC NGGC H+C R C+C
Sbjct: 735 HPLAKPGADPCLYQNGGCEHICKKRLGTAWCSC 767
Score = 191 bits (465), Expect = 2e-47
Identities = 108/346 (31%), Positives = 180/346 (52%), Gaps = 9/346 (2%)
Query: 1018 GCGK-NNGGCSHLCL-LKPGGRSCACPIGIKLNKDGKTCA-DGPINYLIFAHRVDIRVIS 1074
GC +NGGCS LC+ L P C C G L D K+CA GP +L+FA+ DIR +
Sbjct: 438 GCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMH 497
Query: 1075 LDVPYLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLH 1134
D ++ + AL D D IY+ T + I+RA G+ E +I G+
Sbjct: 498 FDGTDYGTLLSQQMGMVYAL--DHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVD 555
Query: 1135 TADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWS 1194
+G+ +D GR+ YWTD G++ I ++L+G+ K++ + PR IA+H +FW+
Sbjct: 556 VPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWT 615
Query: 1195 DWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHD 1254
D G + +IE + + G R VI + + WP+G+ ID + +LYW DAK IE ++ DG
Sbjct: 616 DTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSK 675
Query: 1255 RRTVLSN-VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQ 1313
RR + N V +P+ + + +++++DW ++ R +K D + ++ ++ + +
Sbjct: 676 RRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVRLQGSMLKPSSLVVVH 735
Query: 1314 S-ERVLENACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQT 1358
+ + C NGGC H+C + C+C G F K++ +T
Sbjct: 736 PLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREG--FMKASDGKT 779
Score = 171 bits (417), Expect = 1e-41
Identities = 103/342 (30%), Positives = 166/342 (48%), Gaps = 31/342 (9%)
Query: 762 MDIHSRSCEET-PEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKS 820
+ + +SC + P+ LL+A +D+R + L + + ALD D
Sbjct: 469 LQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLS-----QQMGMVYALDHDPVE 523
Query: 821 NSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSK 880
N I++ I RA ++GS + +++ + P GLA DWI + YWTD G + I S
Sbjct: 524 NKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSD 583
Query: 881 SDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTW 940
+G ++ ++I +PR I V+P ++W+D G +P IE + + G R + + W
Sbjct: 584 LNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIW 643
Query: 941 PNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN-LPHPFGLDLYGDEVFWTDWD 999
P+G+ +D + +++YW D IE ANLDG+ R +L +N + HPF + ++ D V+++DW
Sbjct: 644 PSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWA 703
Query: 1000 TQSIQAANKDTGAKR-RTLG---------------------CGKNNGGCSHLCLLKPGGR 1037
S+ NK TG R R G C NGGC H+C + G
Sbjct: 704 MPSVIRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTA 763
Query: 1038 SCACPIGIKLNKDGKTCADGPINYLIFAHRVDIR--VISLDV 1077
C+C G DGKTC + L+ VD++ V LD+
Sbjct: 764 WCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDI 805
Score = 101 bits (243), Expect = 2e-20
Identities = 79/279 (28%), Positives = 122/279 (43%), Gaps = 13/279 (4%)
Query: 1017 LGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCA--DGPINYLIFAHRVDIRVIS 1074
+ C +N CSH C+L G C CP G L +DGKTC+ P N V + +S
Sbjct: 399 VSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVS 458
Query: 1075 LDVPYLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLH 1134
+ L L A L++ + I+ GT T++ +
Sbjct: 459 WECDCFPGYDLQLDEKSCAAS---GPQPFLLF---ANSQDIRHMHFDGTDYGTLLSQQMG 512
Query: 1135 TADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWS 1194
+ D KIY+ IE A +DG R+ L+ G+D P +A+ + +W+
Sbjct: 513 MVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWT 572
Query: 1195 DWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKI-LTIESSDFDGH 1253
D G S I R+D++G ++I I P G+A+ + RL+W D I IESS G
Sbjct: 573 DRGKSL-IGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGL 631
Query: 1254 DRRTVL-SNVPYPYGIVI--VGQHIYWTDWKTKALHRAD 1289
R + S++ +P GI I + +YW D K + A+
Sbjct: 632 GRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMAN 670
Score = 99.1 bits (236), Expect = 1e-19
Identities = 74/309 (23%), Positives = 146/309 (47%), Gaps = 28/309 (9%)
Query: 1366 PEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRS 1425
P FLIF+ SI I E + V + ++ +D+H++ K I++ DL+ +++
Sbjct: 44 PAPFLIFSHGNSIFRIDTEGTNYEQL---VVDAGVSVIMDFHYNEKRIYWVDLERQLLQR 100
Query: 1426 INMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITGLT 1485
+ + + + +K +G+ ++WI + W++ + +I V + G++ +L++ L
Sbjct: 101 VFLNGSRQERVCNIEK--NVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSALK 158
Query: 1486 EPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYW 1545
P +A+ P + +++WS + R+ LDG + +++ +++D ++RL+W
Sbjct: 159 YPANVAVDPVERFIFWSS-EVAGSLYRADLDGVGVKALLETSEKI-TAVSLDVLDKRLFW 216
Query: 1546 ----TDALKDRIDTSDLN-GQHRVQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRT 1600
+ I + D + G + P N F M+ F D I+++ W K+I A+K T
Sbjct: 217 IQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHT 276
Query: 1601 GKNITLIRTNLEMAM----EIKAVSADRQ-----HGWNP----CKESNGGCSH-LCLFRG 1646
GK+ ++R NL + E+K V Q W P CK G CS +C
Sbjct: 277 GKD--MVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDL 334
Query: 1647 HEYICACPD 1655
++C C +
Sbjct: 335 QSHLCMCAE 343
Score = 93.5 bits (222), Expect = 6e-18
Identities = 60/256 (23%), Positives = 124/256 (48%), Gaps = 10/256 (3%)
Query: 497 CMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEK 556
C G + +C G +P L+FS+ I ++ G NY +V +V +D+HY +
Sbjct: 28 CPEGTLAGNGNSTC--VGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYNE 85
Query: 557 KLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVAT 616
K ++W + ++++ +N V + +G+A++WI++ + W++ + V
Sbjct: 86 KRIYWVDLERQLLQRVFLNGSRQERVCNIE-KNVSGMAINWINEEVIWSNQQEGIITVTD 144
Query: 617 LDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFW 676
+ G+ +L+ + L P +AV P + +FW+ + RAD+DG K ++ +
Sbjct: 145 MKGNNSHILL-SALKYPANVAVDPVERFIFWSSEVAG-SLYRADLDGVGVKALL-ETSEK 201
Query: 677 PNGLTIDYTESKIYW----ADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYW 732
+++D + +++W + + +I +DG + FA++LF D I++
Sbjct: 202 ITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFY 261
Query: 733 TDWHTKSISTVNKNTG 748
+ W K+I NK+TG
Sbjct: 262 STWKMKTIWIANKHTG 277
Score = 92.7 bits (220), Expect = 1e-17
Identities = 58/209 (27%), Positives = 108/209 (51%), Gaps = 15/209 (7%)
Query: 811 AVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTI--VDSNLIWPAGLAFDWITDKIYW 868
+V +D+ I+W D+E+ + R +LNGS Q + ++ N+ +G+A +WI +++ W
Sbjct: 76 SVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNV---SGMAINWINEEVIW 132
Query: 869 TDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGG 928
++ I V+ G+ +L + P ++ V+P ++WS A + RAD+DG
Sbjct: 133 SNQQEGIITVTDMKGNNSHILL-SALKYPANVAVDPVERFIFWSSEVAG-SLYRADLDGV 190
Query: 929 NRKKLIFGQMTWPNGLALDLVHNRIYW----TDGGNKTIEYANLDGTGRTKLIEN-LPHP 983
K L+ ++LD++ R++W +G N I + DG G + ++ H
Sbjct: 191 GVKALL-ETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDG-GSVHISKHPTQHN 248
Query: 984 -FGLDLYGDEVFWTDWDTQSIQAANKDTG 1011
F + L+GD +F++ W ++I ANK TG
Sbjct: 249 LFAMSLFGDRIFYSTWKMKTIWIANKHTG 277
Score = 87.4 bits (207), Expect = 4e-16
Identities = 80/365 (21%), Positives = 143/365 (39%), Gaps = 11/365 (3%)
Query: 385 EEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSA-EEKCEKLC 443
E +Q C+ ++ S+ + H+C + D + C +C+ C C
Sbjct: 312 EPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGC 371
Query: 444 ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYIL 503
T G C CP+GF+L D C + C CS C T C C G +L
Sbjct: 372 KNT-PGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSE-CSHDCVLTSEGPLCFCPEGSVL 429
Query: 504 RPDERSCKPTGESPTLLFSNR-IGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLVFWS 562
D ++C S + + V D + L + L+F
Sbjct: 430 ERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLF-- 487
Query: 563 ENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSKR 622
N + IR + + ++ + + D + + +++ + + +E A +DGS+R
Sbjct: 488 -ANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQR 546
Query: 623 AVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTI 682
L+ +D P +AV +WTD G + I R+D++G + K + + I P G+ +
Sbjct: 547 ERLIEEGVDVPEGLAVDWIGRRFYWTDRGKS-LIGRSDLNGKRSKIITKENISQPRGIAV 605
Query: 683 DYTESKIYWADAK-HHVIERAAFDGRDRRKVTTKGLPHPFALTL--FDDAIYWTDWHTKS 739
+++W D + IE ++ G R + + L P +T+ D +YW D
Sbjct: 606 HPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSV 665
Query: 740 ISTVN 744
I N
Sbjct: 666 IEMAN 670
Score = 80.2 bits (189), Expect = 6e-14
Identities = 65/269 (24%), Positives = 121/269 (44%), Gaps = 15/269 (5%)
Query: 1040 ACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNALGVDVD 1099
+CP G TC GP +LIF+H I I + +V+ ++ +D
Sbjct: 27 SCPEGTLAGNGNSTCV-GPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGV---SVIMDFH 82
Query: 1100 HSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIE 1159
++ IYW D ++ +QR G+ E V N G+ I+ ++ W++ I
Sbjct: 83 YNEKRIYWVDLERQLLQRVFLNGSRQERVC-NIEKNVSGMAINWINEEVIWSNQQEGIIT 141
Query: 1160 VAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNK 1219
V ++ G N +L+ + L P +A+ ++FWS + + RAD+DG + +++
Sbjct: 142 VTDMKGNNSHILL-SALKYPANVAVDPVERFIFWSS-EVAGSLYRADLDGVGVKALLETS 199
Query: 1220 IKWPNGLAIDRIEGRLYW----NDAKILTIESSDFDGHDRRTVLSNVPYP-YGIVIVGQH 1274
K +++D ++ RL+W + I S D+DG + + + + G
Sbjct: 200 EK-ITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDR 258
Query: 1275 IYWTDWKTKALHRADKTNASDPIVIRKNL 1303
I+++ WK K + A+K D ++R NL
Sbjct: 259 IFYSTWKMKTIWIANKHTGKD--MVRINL 285
Score = 62.1 bits (144), Expect = 2e-08
Identities = 29/94 (30%), Positives = 47/94 (50%), Gaps = 4/94 (4%)
Query: 419 PRGDDEERCPLKRKCSAEE-KCEK-LCITTYDGHAACACPMGFLLAEDKYSCRDIDECMY 476
P+ +D+ P ++ C + C +C H C C G+ L+ D+ C D++EC +
Sbjct: 304 PKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHL-CMCAEGYALSRDRKYCEDVNECAF 362
Query: 477 EQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSC 510
C+ C NT GS+ C C G++L PD + C
Sbjct: 363 WNHG-CTLGCKNTPGSYYCTCPVGFVLLPDGKRC 395
Score = 50.4 bits (115), Expect = 6e-05
Identities = 81/328 (24%), Positives = 140/328 (42%), Gaps = 30/328 (9%)
Query: 736 HTKSISTVN-KNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESKK 794
H SI ++ + T V AG++V MD H EK + + DL + L+
Sbjct: 52 HGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYN------EKRIYWV---DLERQLLQRVF 102
Query: 795 PIDSL-DMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIW 853
S + V +E S +A++W + + W++ ++ I + G++ ++ S L +
Sbjct: 103 LNGSRQERVCNIEKNVSGMAINWINEE--VIWSNQQEGIITVTDMKGNNSHILL-SALKY 159
Query: 854 PAGLAFDWITDKIYWTDGGTNRIEVSKSDG-SMRTLLAWDHIDKPRDIVVNPEGGVMYWS 912
PA +A D + I+W+ + + DG ++ LL + +K + ++ ++W
Sbjct: 160 PANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALL--ETSEKITAVSLDVLDKRLFWI 217
Query: 913 DW---GASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLD 969
+ G++ I D DGG+ I T N A+ L +RI+++ KTI AN
Sbjct: 218 QYNREGSNSLICSCDYDGGSVH--ISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKH 275
Query: 970 GTGRTKLIENLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTLGCGKNNGGCSH- 1028
TG+ + NL F + L +V + A DT + L C G CS
Sbjct: 276 -TGKDMVRINLHSSF-VPLGELKVV----HPLAQPKAEDDTWEPEQKL-CKLRKGNCSST 328
Query: 1029 LCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
+C C C G L++D K C D
Sbjct: 329 VCGQDLQSHLCMCAEGYALSRDRKYCED 356
Score = 42.3 bits (95), Expect = 0.015
Identities = 25/54 (46%), Positives = 26/54 (48%), Gaps = 6/54 (11%)
Query: 451 AACACPMGFLLAEDKYSCRDIDECMYEQDPVC---SQTCSNTVGSFRCGCMTGY 501
A C C GF A D C DIDEC PVC S C NT G + C C GY
Sbjct: 853 ATCQCLKGF--AGDGKLCSDIDECEMGV-PVCPPASSKCINTEGGYVCRCSEGY 903
Score = 37.9 bits (84), Expect = 0.33
Identities = 16/36 (44%), Positives = 18/36 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C N GC+ C PG C CP+G L DGK C
Sbjct: 360 CAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRC 395
Score = 36.7 bits (81), Expect = 0.76
Identities = 21/57 (36%), Positives = 27/57 (47%), Gaps = 6/57 (10%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ--TCSNTVGSFRCGC 497
CI T G+ C C G+ D C DIDEC C + +C+NT G + C C
Sbjct: 888 CINTEGGYV-CRCSEGY--QGDGIHCLDIDECQLGVHS-CGENASCTNTEGGYTCMC 940
>BC113461-1|AAI13462.1| 1207|Homo sapiens epidermal growth factor
(beta-urogastrone) protein.
Length = 1207
Score = 229 bits (561), Expect = 5e-59
Identities = 119/338 (35%), Positives = 181/338 (53%), Gaps = 11/338 (3%)
Query: 418 CPRG----DDEERCPLKRKCSAE-EKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDID 472
CP G D +RC C +C C+ T +G C CP G +L D +C
Sbjct: 382 CPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEG-PLCFCPEGSVLERDGKTCSG-- 438
Query: 473 ECMYEQDPVCSQTCSN-TVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVW 531
C + CSQ C + S+ C C GY L+ DE+SC +G P LLF+N IR +
Sbjct: 439 -CSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMH 497
Query: 532 LTGDNYMSVVKGLHNAV-ALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETP 590
G +Y +++ V ALD+ + ++++ L+ I A M+ +I G++ P
Sbjct: 498 FDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVP 557
Query: 591 AGVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDW 650
G+AVDWI +WTD G + + L+G + ++ ++ +PR IAVHP +FWTD
Sbjct: 558 EGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDT 617
Query: 651 GPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRR 710
G NP+IE + + G R + ++ WP+G+TID+ K+YW DAK VIE A DG RR
Sbjct: 618 GINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRR 677
Query: 711 KVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTG 748
++T + HPFA+ +F+D ++++DW S+ VNK TG
Sbjct: 678 RLTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTG 715
Score = 199 bits (485), Expect = 8e-50
Identities = 111/333 (33%), Positives = 179/333 (53%), Gaps = 12/333 (3%)
Query: 1325 DNGGCSHLCLR-SPLGYTCACPTGMPFEKSTTDQTPKKCK-SHPEEFLIFATRGSITYIS 1382
DNGGCS LC+ SP+ + C C G + D+ K C S P+ FL+FA I ++
Sbjct: 443 DNGGCSQLCVPLSPVSWECDCFPGYDLQ---LDE--KSCAASGPQPFLLFANSQDIRHMH 497
Query: 1383 LESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKL 1442
+ + TL +++ A+D+ I++ L I NM S+ + +I + +
Sbjct: 498 FDGTDYG--TLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDG-SQRERLIEEGV 554
Query: 1443 ETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLIT-GLTEPRALALFPAKGYLYW 1501
+ P GL VDWI YWTD +I + L+G K++ +++PR +A+ P L+W
Sbjct: 555 DVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFW 614
Query: 1502 SDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQ 1561
+D G +P IE S L G R +I DL +P+G+TID+ +LYW DA + I+ ++L+G
Sbjct: 615 TDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGS 674
Query: 1562 HRVQLVP-DAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAV 1620
R +L D +PF + F+DY++++DW S+IR +KRTGK+ ++ ++ + V
Sbjct: 675 KRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVRLQGSMLKPSSLVVV 734
Query: 1621 SADRQHGWNPCKESNGGCSHLCLFRGHEYICAC 1653
+ G +PC NGGC H+C R C+C
Sbjct: 735 HPLAKPGADPCLYQNGGCEHICKKRLGTAWCSC 767
Score = 191 bits (465), Expect = 2e-47
Identities = 108/346 (31%), Positives = 180/346 (52%), Gaps = 9/346 (2%)
Query: 1018 GCGK-NNGGCSHLCL-LKPGGRSCACPIGIKLNKDGKTCA-DGPINYLIFAHRVDIRVIS 1074
GC +NGGCS LC+ L P C C G L D K+CA GP +L+FA+ DIR +
Sbjct: 438 GCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMH 497
Query: 1075 LDVPYLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLH 1134
D ++ + AL D D IY+ T + I+RA G+ E +I G+
Sbjct: 498 FDGTDYGTLLSQQMGMVYAL--DHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVD 555
Query: 1135 TADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWS 1194
+G+ +D GR+ YWTD G++ I ++L+G+ K++ + PR IA+H +FW+
Sbjct: 556 VPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWT 615
Query: 1195 DWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHD 1254
D G + +IE + + G R VI + + WP+G+ ID + +LYW DAK IE ++ DG
Sbjct: 616 DTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSK 675
Query: 1255 RRTVLSN-VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQ 1313
RR + N V +P+ + + +++++DW ++ R +K D + ++ ++ + +
Sbjct: 676 RRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVRLQGSMLKPSSLVVVH 735
Query: 1314 S-ERVLENACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQT 1358
+ + C NGGC H+C + C+C G F K++ +T
Sbjct: 736 PLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREG--FMKASDGKT 779
Score = 171 bits (417), Expect = 1e-41
Identities = 103/342 (30%), Positives = 166/342 (48%), Gaps = 31/342 (9%)
Query: 762 MDIHSRSCEET-PEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKS 820
+ + +SC + P+ LL+A +D+R + L + + ALD D
Sbjct: 469 LQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLS-----QQMGMVYALDHDPVE 523
Query: 821 NSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSK 880
N I++ I RA ++GS + +++ + P GLA DWI + YWTD G + I S
Sbjct: 524 NKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSD 583
Query: 881 SDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTW 940
+G ++ ++I +PR I V+P ++W+D G +P IE + + G R + + W
Sbjct: 584 LNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIW 643
Query: 941 PNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN-LPHPFGLDLYGDEVFWTDWD 999
P+G+ +D + +++YW D IE ANLDG+ R +L +N + HPF + ++ D V+++DW
Sbjct: 644 PSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWA 703
Query: 1000 TQSIQAANKDTGAKR-RTLG---------------------CGKNNGGCSHLCLLKPGGR 1037
S+ NK TG R R G C NGGC H+C + G
Sbjct: 704 MPSVIRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTA 763
Query: 1038 SCACPIGIKLNKDGKTCADGPINYLIFAHRVDIR--VISLDV 1077
C+C G DGKTC + L+ VD++ V LD+
Sbjct: 764 WCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDI 805
Score = 101 bits (243), Expect = 2e-20
Identities = 79/279 (28%), Positives = 122/279 (43%), Gaps = 13/279 (4%)
Query: 1017 LGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCA--DGPINYLIFAHRVDIRVIS 1074
+ C +N CSH C+L G C CP G L +DGKTC+ P N V + +S
Sbjct: 399 VSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVS 458
Query: 1075 LDVPYLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLH 1134
+ L L A L++ + I+ GT T++ +
Sbjct: 459 WECDCFPGYDLQLDEKSCAAS---GPQPFLLF---ANSQDIRHMHFDGTDYGTLLSQQMG 512
Query: 1135 TADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWS 1194
+ D KIY+ IE A +DG R+ L+ G+D P +A+ + +W+
Sbjct: 513 MVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWT 572
Query: 1195 DWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKI-LTIESSDFDGH 1253
D G S I R+D++G ++I I P G+A+ + RL+W D I IESS G
Sbjct: 573 DRGKSL-IGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGL 631
Query: 1254 DRRTVL-SNVPYPYGIVI--VGQHIYWTDWKTKALHRAD 1289
R + S++ +P GI I + +YW D K + A+
Sbjct: 632 GRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMAN 670
Score = 99.1 bits (236), Expect = 1e-19
Identities = 74/309 (23%), Positives = 146/309 (47%), Gaps = 28/309 (9%)
Query: 1366 PEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRS 1425
P FLIF+ SI I E + V + ++ +D+H++ K I++ DL+ +++
Sbjct: 44 PAPFLIFSHGNSIFRIDTEGTNYEQL---VVDAGVSVIMDFHYNEKRIYWVDLERQLLQR 100
Query: 1426 INMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITGLT 1485
+ + + + +K +G+ ++WI + W++ + +I V + G++ +L++ L
Sbjct: 101 VFLNGSRQERVCNIEK--NVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSALK 158
Query: 1486 EPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYW 1545
P +A+ P + +++WS + R+ LDG + +++ +++D ++RL+W
Sbjct: 159 YPANVAVDPVERFIFWSS-EVAGSLYRADLDGVGVKALLETSEKI-TAVSLDVLDKRLFW 216
Query: 1546 ----TDALKDRIDTSDLN-GQHRVQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRT 1600
+ I + D + G + P N F M+ F D I+++ W K+I A+K T
Sbjct: 217 IQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHT 276
Query: 1601 GKNITLIRTNLEMAM----EIKAVSADRQ-----HGWNP----CKESNGGCSH-LCLFRG 1646
GK+ ++R NL + E+K V Q W P CK G CS +C
Sbjct: 277 GKD--MVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDL 334
Query: 1647 HEYICACPD 1655
++C C +
Sbjct: 335 QSHLCMCAE 343
Score = 93.5 bits (222), Expect = 6e-18
Identities = 60/256 (23%), Positives = 124/256 (48%), Gaps = 10/256 (3%)
Query: 497 CMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEK 556
C G + +C G +P L+FS+ I ++ G NY +V +V +D+HY +
Sbjct: 28 CPEGTLAGNGNSTC--VGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYNE 85
Query: 557 KLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVAT 616
K ++W + ++++ +N V + +G+A++WI++ + W++ + V
Sbjct: 86 KRIYWVDLERQLLQRVFLNGSRQERVCNIE-KNVSGMAINWINEEVIWSNQQEGIITVTD 144
Query: 617 LDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFW 676
+ G+ +L+ + L P +AV P + +FW+ + RAD+DG K ++ +
Sbjct: 145 MKGNNSHILL-SALKYPANVAVDPVERFIFWSSEVAG-SLYRADLDGVGVKALL-ETSEK 201
Query: 677 PNGLTIDYTESKIYW----ADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYW 732
+++D + +++W + + +I +DG + FA++LF D I++
Sbjct: 202 ITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFY 261
Query: 733 TDWHTKSISTVNKNTG 748
+ W K+I NK+TG
Sbjct: 262 STWKMKTIWIANKHTG 277
Score = 92.7 bits (220), Expect = 1e-17
Identities = 58/209 (27%), Positives = 108/209 (51%), Gaps = 15/209 (7%)
Query: 811 AVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTI--VDSNLIWPAGLAFDWITDKIYW 868
+V +D+ I+W D+E+ + R +LNGS Q + ++ N+ +G+A +WI +++ W
Sbjct: 76 SVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNV---SGMAINWINEEVIW 132
Query: 869 TDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGG 928
++ I V+ G+ +L + P ++ V+P ++WS A + RAD+DG
Sbjct: 133 SNQQEGIITVTDMKGNNSHILL-SALKYPANVAVDPVERFIFWSSEVAG-SLYRADLDGV 190
Query: 929 NRKKLIFGQMTWPNGLALDLVHNRIYW----TDGGNKTIEYANLDGTGRTKLIEN-LPHP 983
K L+ ++LD++ R++W +G N I + DG G + ++ H
Sbjct: 191 GVKALL-ETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDG-GSVHISKHPTQHN 248
Query: 984 -FGLDLYGDEVFWTDWDTQSIQAANKDTG 1011
F + L+GD +F++ W ++I ANK TG
Sbjct: 249 LFAMSLFGDRIFYSTWKMKTIWIANKHTG 277
Score = 87.4 bits (207), Expect = 4e-16
Identities = 80/365 (21%), Positives = 143/365 (39%), Gaps = 11/365 (3%)
Query: 385 EEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSA-EEKCEKLC 443
E +Q C+ ++ S+ + H+C + D + C +C+ C C
Sbjct: 312 EPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGC 371
Query: 444 ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYIL 503
T G C CP+GF+L D C + C CS C T C C G +L
Sbjct: 372 KNT-PGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSE-CSHDCVLTSEGPLCFCPEGSVL 429
Query: 504 RPDERSCKPTGESPTLLFSNR-IGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLVFWS 562
D ++C S + + V D + L + L+F
Sbjct: 430 ERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLF-- 487
Query: 563 ENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSKR 622
N + IR + + ++ + + D + + +++ + + +E A +DGS+R
Sbjct: 488 -ANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQR 546
Query: 623 AVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTI 682
L+ +D P +AV +WTD G + I R+D++G + K + + I P G+ +
Sbjct: 547 ERLIEEGVDVPEGLAVDWIGRRFYWTDRGKS-LIGRSDLNGKRSKIITKENISQPRGIAV 605
Query: 683 DYTESKIYWADAK-HHVIERAAFDGRDRRKVTTKGLPHPFALTL--FDDAIYWTDWHTKS 739
+++W D + IE ++ G R + + L P +T+ D +YW D
Sbjct: 606 HPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSV 665
Query: 740 ISTVN 744
I N
Sbjct: 666 IEMAN 670
Score = 80.2 bits (189), Expect = 6e-14
Identities = 65/269 (24%), Positives = 121/269 (44%), Gaps = 15/269 (5%)
Query: 1040 ACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNALGVDVD 1099
+CP G TC GP +LIF+H I I + +V+ ++ +D
Sbjct: 27 SCPEGTLAGNGNSTCV-GPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGV---SVIMDFH 82
Query: 1100 HSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIE 1159
++ IYW D ++ +QR G+ E V N G+ I+ ++ W++ I
Sbjct: 83 YNEKRIYWVDLERQLLQRVFLNGSRQERVC-NIEKNVSGMAINWINEEVIWSNQQEGIIT 141
Query: 1160 VAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNK 1219
V ++ G N +L+ + L P +A+ ++FWS + + RAD+DG + +++
Sbjct: 142 VTDMKGNNSHILL-SALKYPANVAVDPVERFIFWSS-EVAGSLYRADLDGVGVKALLETS 199
Query: 1220 IKWPNGLAIDRIEGRLYW----NDAKILTIESSDFDGHDRRTVLSNVPYP-YGIVIVGQH 1274
K +++D ++ RL+W + I S D+DG + + + + G
Sbjct: 200 EK-ITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDR 258
Query: 1275 IYWTDWKTKALHRADKTNASDPIVIRKNL 1303
I+++ WK K + A+K D ++R NL
Sbjct: 259 IFYSTWKMKTIWIANKHTGKD--MVRINL 285
Score = 62.1 bits (144), Expect = 2e-08
Identities = 29/94 (30%), Positives = 47/94 (50%), Gaps = 4/94 (4%)
Query: 419 PRGDDEERCPLKRKCSAEE-KCEK-LCITTYDGHAACACPMGFLLAEDKYSCRDIDECMY 476
P+ +D+ P ++ C + C +C H C C G+ L+ D+ C D++EC +
Sbjct: 304 PKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHL-CMCAEGYALSRDRKYCEDVNECAF 362
Query: 477 EQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSC 510
C+ C NT GS+ C C G++L PD + C
Sbjct: 363 WNHG-CTLGCKNTPGSYYCTCPVGFVLLPDGKRC 395
Score = 50.4 bits (115), Expect = 6e-05
Identities = 81/328 (24%), Positives = 140/328 (42%), Gaps = 30/328 (9%)
Query: 736 HTKSISTVN-KNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESKK 794
H SI ++ + T V AG++V MD H EK + + DL + L+
Sbjct: 52 HGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYN------EKRIYWV---DLERQLLQRVF 102
Query: 795 PIDSL-DMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIW 853
S + V +E S +A++W + + W++ ++ I + G++ ++ S L +
Sbjct: 103 LNGSRQERVCNIEKNVSGMAINWINEE--VIWSNQQEGIITVTDMKGNNSHILL-SALKY 159
Query: 854 PAGLAFDWITDKIYWTDGGTNRIEVSKSDG-SMRTLLAWDHIDKPRDIVVNPEGGVMYWS 912
PA +A D + I+W+ + + DG ++ LL + +K + ++ ++W
Sbjct: 160 PANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALL--ETSEKITAVSLDVLDKRLFWI 217
Query: 913 DW---GASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLD 969
+ G++ I D DGG+ I T N A+ L +RI+++ KTI AN
Sbjct: 218 QYNREGSNSLICSCDYDGGSVH--ISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKH 275
Query: 970 GTGRTKLIENLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTLGCGKNNGGCSH- 1028
TG+ + NL F + L +V + A DT + L C G CS
Sbjct: 276 -TGKDMVRINLHSSF-VPLGELKVV----HPLAQPKAEDDTWEPEQKL-CKLRKGNCSST 328
Query: 1029 LCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
+C C C G L++D K C D
Sbjct: 329 VCGQDLQSHLCMCAEGYALSRDRKYCED 356
Score = 42.3 bits (95), Expect = 0.015
Identities = 25/54 (46%), Positives = 26/54 (48%), Gaps = 6/54 (11%)
Query: 451 AACACPMGFLLAEDKYSCRDIDECMYEQDPVC---SQTCSNTVGSFRCGCMTGY 501
A C C GF A D C DIDEC PVC S C NT G + C C GY
Sbjct: 853 ATCQCLKGF--AGDGKLCSDIDECEMGV-PVCPPASSKCINTEGGYVCRCSEGY 903
Score = 37.9 bits (84), Expect = 0.33
Identities = 16/36 (44%), Positives = 18/36 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C N GC+ C PG C CP+G L DGK C
Sbjct: 360 CAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRC 395
Score = 36.7 bits (81), Expect = 0.76
Identities = 21/57 (36%), Positives = 27/57 (47%), Gaps = 6/57 (10%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ--TCSNTVGSFRCGC 497
CI T G+ C C G+ D C DIDEC C + +C+NT G + C C
Sbjct: 888 CINTEGGYV-CRCSEGY--QGDGIHCLDIDECQLGVHS-CGENASCTNTEGGYTCMC 940
>BC093731-1|AAH93731.1| 1207|Homo sapiens epidermal growth factor
(beta-urogastrone) protein.
Length = 1207
Score = 229 bits (561), Expect = 5e-59
Identities = 119/338 (35%), Positives = 181/338 (53%), Gaps = 11/338 (3%)
Query: 418 CPRG----DDEERCPLKRKCSAE-EKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDID 472
CP G D +RC C +C C+ T +G C CP G +L D +C
Sbjct: 382 CPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEG-PLCFCPEGSVLERDGKTCSG-- 438
Query: 473 ECMYEQDPVCSQTCSN-TVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVW 531
C + CSQ C + S+ C C GY L+ DE+SC +G P LLF+N IR +
Sbjct: 439 -CSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMH 497
Query: 532 LTGDNYMSVVKGLHNAV-ALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETP 590
G +Y +++ V ALD+ + ++++ L+ I A M+ +I G++ P
Sbjct: 498 FDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVP 557
Query: 591 AGVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDW 650
G+AVDWI +WTD G + + L+G + ++ ++ +PR IAVHP +FWTD
Sbjct: 558 EGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDT 617
Query: 651 GPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRR 710
G NP+IE + + G R + ++ WP+G+TID+ K+YW DAK VIE A DG RR
Sbjct: 618 GINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRR 677
Query: 711 KVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTG 748
++T + HPFA+ +F+D ++++DW S+ VNK TG
Sbjct: 678 RLTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTG 715
Score = 199 bits (485), Expect = 8e-50
Identities = 111/333 (33%), Positives = 179/333 (53%), Gaps = 12/333 (3%)
Query: 1325 DNGGCSHLCLR-SPLGYTCACPTGMPFEKSTTDQTPKKCK-SHPEEFLIFATRGSITYIS 1382
DNGGCS LC+ SP+ + C C G + D+ K C S P+ FL+FA I ++
Sbjct: 443 DNGGCSQLCVPLSPVSWECDCFPGYDLQ---LDE--KSCAASGPQPFLLFANSQDIRHMH 497
Query: 1383 LESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKL 1442
+ + TL +++ A+D+ I++ L I NM S+ + +I + +
Sbjct: 498 FDGTDYG--TLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDG-SQRERLIEEGV 554
Query: 1443 ETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLIT-GLTEPRALALFPAKGYLYW 1501
+ P GL VDWI YWTD +I + L+G K++ +++PR +A+ P L+W
Sbjct: 555 DVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFW 614
Query: 1502 SDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQ 1561
+D G +P IE S L G R +I DL +P+G+TID+ +LYW DA + I+ ++L+G
Sbjct: 615 TDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGS 674
Query: 1562 HRVQLVP-DAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAV 1620
R +L D +PF + F+DY++++DW S+IR +KRTGK+ ++ ++ + V
Sbjct: 675 KRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVRLQGSMLKPSSLVVV 734
Query: 1621 SADRQHGWNPCKESNGGCSHLCLFRGHEYICAC 1653
+ G +PC NGGC H+C R C+C
Sbjct: 735 HPLAKPGADPCLYQNGGCEHICKKRLGTAWCSC 767
Score = 191 bits (465), Expect = 2e-47
Identities = 108/346 (31%), Positives = 180/346 (52%), Gaps = 9/346 (2%)
Query: 1018 GCGK-NNGGCSHLCL-LKPGGRSCACPIGIKLNKDGKTCA-DGPINYLIFAHRVDIRVIS 1074
GC +NGGCS LC+ L P C C G L D K+CA GP +L+FA+ DIR +
Sbjct: 438 GCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMH 497
Query: 1075 LDVPYLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLH 1134
D ++ + AL D D IY+ T + I+RA G+ E +I G+
Sbjct: 498 FDGTDYGTLLSQQMGMVYAL--DHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVD 555
Query: 1135 TADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWS 1194
+G+ +D GR+ YWTD G++ I ++L+G+ K++ + PR IA+H +FW+
Sbjct: 556 VPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWT 615
Query: 1195 DWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHD 1254
D G + +IE + + G R VI + + WP+G+ ID + +LYW DAK IE ++ DG
Sbjct: 616 DTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSK 675
Query: 1255 RRTVLSN-VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQ 1313
RR + N V +P+ + + +++++DW ++ R +K D + ++ ++ + +
Sbjct: 676 RRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVRLQGSMLKPSSLVVVH 735
Query: 1314 S-ERVLENACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQT 1358
+ + C NGGC H+C + C+C G F K++ +T
Sbjct: 736 PLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREG--FMKASDGKT 779
Score = 171 bits (417), Expect = 1e-41
Identities = 103/342 (30%), Positives = 166/342 (48%), Gaps = 31/342 (9%)
Query: 762 MDIHSRSCEET-PEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKS 820
+ + +SC + P+ LL+A +D+R + L + + ALD D
Sbjct: 469 LQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLS-----QQMGMVYALDHDPVE 523
Query: 821 NSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSK 880
N I++ I RA ++GS + +++ + P GLA DWI + YWTD G + I S
Sbjct: 524 NKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSD 583
Query: 881 SDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTW 940
+G ++ ++I +PR I V+P ++W+D G +P IE + + G R + + W
Sbjct: 584 LNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIW 643
Query: 941 PNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN-LPHPFGLDLYGDEVFWTDWD 999
P+G+ +D + +++YW D IE ANLDG+ R +L +N + HPF + ++ D V+++DW
Sbjct: 644 PSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWA 703
Query: 1000 TQSIQAANKDTGAKR-RTLG---------------------CGKNNGGCSHLCLLKPGGR 1037
S+ NK TG R R G C NGGC H+C + G
Sbjct: 704 MPSVIRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTA 763
Query: 1038 SCACPIGIKLNKDGKTCADGPINYLIFAHRVDIR--VISLDV 1077
C+C G DGKTC + L+ VD++ V LD+
Sbjct: 764 WCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDI 805
Score = 101 bits (243), Expect = 2e-20
Identities = 79/279 (28%), Positives = 122/279 (43%), Gaps = 13/279 (4%)
Query: 1017 LGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCA--DGPINYLIFAHRVDIRVIS 1074
+ C +N CSH C+L G C CP G L +DGKTC+ P N V + +S
Sbjct: 399 VSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVS 458
Query: 1075 LDVPYLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLH 1134
+ L L A L++ + I+ GT T++ +
Sbjct: 459 WECDCFPGYDLQLDEKSCAAS---GPQPFLLF---ANSQDIRHMHFDGTDYGTLLSQQMG 512
Query: 1135 TADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWS 1194
+ D KIY+ IE A +DG R+ L+ G+D P +A+ + +W+
Sbjct: 513 MVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWT 572
Query: 1195 DWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKI-LTIESSDFDGH 1253
D G S I R+D++G ++I I P G+A+ + RL+W D I IESS G
Sbjct: 573 DRGKSL-IGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGL 631
Query: 1254 DRRTVL-SNVPYPYGIVI--VGQHIYWTDWKTKALHRAD 1289
R + S++ +P GI I + +YW D K + A+
Sbjct: 632 GRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMAN 670
Score = 99.1 bits (236), Expect = 1e-19
Identities = 74/309 (23%), Positives = 146/309 (47%), Gaps = 28/309 (9%)
Query: 1366 PEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRS 1425
P FLIF+ SI I E + V + ++ +D+H++ K I++ DL+ +++
Sbjct: 44 PAPFLIFSHGNSIFRIDTEGTNYEQL---VVDAGVSVIMDFHYNEKRIYWVDLERQLLQR 100
Query: 1426 INMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITGLT 1485
+ + + + +K +G+ ++WI + W++ + +I V + G++ +L++ L
Sbjct: 101 VFLNGSRQERVCNIEK--NVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSALK 158
Query: 1486 EPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYW 1545
P +A+ P + +++WS + R+ LDG + +++ +++D ++RL+W
Sbjct: 159 YPANVAVDPVERFIFWSS-EVAGSLYRADLDGVGVKALLETSEKI-TAVSLDVLDKRLFW 216
Query: 1546 ----TDALKDRIDTSDLN-GQHRVQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRT 1600
+ I + D + G + P N F M+ F D I+++ W K+I A+K T
Sbjct: 217 IQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHT 276
Query: 1601 GKNITLIRTNLEMAM----EIKAVSADRQ-----HGWNP----CKESNGGCSH-LCLFRG 1646
GK+ ++R NL + E+K V Q W P CK G CS +C
Sbjct: 277 GKD--MVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDL 334
Query: 1647 HEYICACPD 1655
++C C +
Sbjct: 335 QSHLCMCAE 343
Score = 93.5 bits (222), Expect = 6e-18
Identities = 60/256 (23%), Positives = 124/256 (48%), Gaps = 10/256 (3%)
Query: 497 CMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEK 556
C G + +C G +P L+FS+ I ++ G NY +V +V +D+HY +
Sbjct: 28 CPEGTLAGNGNSTC--VGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYNE 85
Query: 557 KLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVAT 616
K ++W + ++++ +N V + +G+A++WI++ + W++ + V
Sbjct: 86 KRIYWVDLERQLLQRVFLNGSRQERVCNIE-KNVSGMAINWINEEVIWSNQQEGIITVTD 144
Query: 617 LDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFW 676
+ G+ +L+ + L P +AV P + +FW+ + RAD+DG K ++ +
Sbjct: 145 MKGNNSHILL-SALKYPANVAVDPVERFIFWSSEVAG-SLYRADLDGVGVKALL-ETSEK 201
Query: 677 PNGLTIDYTESKIYW----ADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYW 732
+++D + +++W + + +I +DG + FA++LF D I++
Sbjct: 202 ITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFY 261
Query: 733 TDWHTKSISTVNKNTG 748
+ W K+I NK+TG
Sbjct: 262 STWKMKTIWIANKHTG 277
Score = 92.7 bits (220), Expect = 1e-17
Identities = 58/209 (27%), Positives = 108/209 (51%), Gaps = 15/209 (7%)
Query: 811 AVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTI--VDSNLIWPAGLAFDWITDKIYW 868
+V +D+ I+W D+E+ + R +LNGS Q + ++ N+ +G+A +WI +++ W
Sbjct: 76 SVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNV---SGMAINWINEEVIW 132
Query: 869 TDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGG 928
++ I V+ G+ +L + P ++ V+P ++WS A + RAD+DG
Sbjct: 133 SNQQEGIITVTDMKGNNSHILL-SALKYPANVAVDPVERFIFWSSEVAG-SLYRADLDGV 190
Query: 929 NRKKLIFGQMTWPNGLALDLVHNRIYW----TDGGNKTIEYANLDGTGRTKLIEN-LPHP 983
K L+ ++LD++ R++W +G N I + DG G + ++ H
Sbjct: 191 GVKALL-ETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDG-GSVHISKHPTQHN 248
Query: 984 -FGLDLYGDEVFWTDWDTQSIQAANKDTG 1011
F + L+GD +F++ W ++I ANK TG
Sbjct: 249 LFAMSLFGDRIFYSTWKMKTIWIANKHTG 277
Score = 87.4 bits (207), Expect = 4e-16
Identities = 80/365 (21%), Positives = 143/365 (39%), Gaps = 11/365 (3%)
Query: 385 EEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSA-EEKCEKLC 443
E +Q C+ ++ S+ + H+C + D + C +C+ C C
Sbjct: 312 EPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGC 371
Query: 444 ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYIL 503
T G C CP+GF+L D C + C CS C T C C G +L
Sbjct: 372 KNT-PGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSE-CSHDCVLTSEGPLCFCPEGSVL 429
Query: 504 RPDERSCKPTGESPTLLFSNR-IGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLVFWS 562
D ++C S + + V D + L + L+F
Sbjct: 430 ERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLF-- 487
Query: 563 ENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSKR 622
N + IR + + ++ + + D + + +++ + + +E A +DGS+R
Sbjct: 488 -ANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQR 546
Query: 623 AVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTI 682
L+ +D P +AV +WTD G + I R+D++G + K + + I P G+ +
Sbjct: 547 ERLIEEGVDVPEGLAVDWIGRRFYWTDRGKS-LIGRSDLNGKRSKIITKENISQPRGIAV 605
Query: 683 DYTESKIYWADAK-HHVIERAAFDGRDRRKVTTKGLPHPFALTL--FDDAIYWTDWHTKS 739
+++W D + IE ++ G R + + L P +T+ D +YW D
Sbjct: 606 HPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSV 665
Query: 740 ISTVN 744
I N
Sbjct: 666 IEMAN 670
Score = 80.2 bits (189), Expect = 6e-14
Identities = 65/269 (24%), Positives = 121/269 (44%), Gaps = 15/269 (5%)
Query: 1040 ACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNALGVDVD 1099
+CP G TC GP +LIF+H I I + +V+ ++ +D
Sbjct: 27 SCPEGTLAGNGNSTCV-GPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGV---SVIMDFH 82
Query: 1100 HSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIE 1159
++ IYW D ++ +QR G+ E V N G+ I+ ++ W++ I
Sbjct: 83 YNEKRIYWVDLERQLLQRVFLNGSRQERVC-NIEKNVSGMAINWINEEVIWSNQQEGIIT 141
Query: 1160 VAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNK 1219
V ++ G N +L+ + L P +A+ ++FWS + + RAD+DG + +++
Sbjct: 142 VTDMKGNNSHILL-SALKYPANVAVDPVERFIFWSS-EVAGSLYRADLDGVGVKALLETS 199
Query: 1220 IKWPNGLAIDRIEGRLYW----NDAKILTIESSDFDGHDRRTVLSNVPYP-YGIVIVGQH 1274
K +++D ++ RL+W + I S D+DG + + + + G
Sbjct: 200 EK-ITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDR 258
Query: 1275 IYWTDWKTKALHRADKTNASDPIVIRKNL 1303
I+++ WK K + A+K D ++R NL
Sbjct: 259 IFYSTWKMKTIWIANKHTGKD--MVRINL 285
Score = 62.1 bits (144), Expect = 2e-08
Identities = 29/94 (30%), Positives = 47/94 (50%), Gaps = 4/94 (4%)
Query: 419 PRGDDEERCPLKRKCSAEE-KCEK-LCITTYDGHAACACPMGFLLAEDKYSCRDIDECMY 476
P+ +D+ P ++ C + C +C H C C G+ L+ D+ C D++EC +
Sbjct: 304 PKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHL-CMCAEGYALSRDRKYCEDVNECAF 362
Query: 477 EQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSC 510
C+ C NT GS+ C C G++L PD + C
Sbjct: 363 WNHG-CTLGCKNTPGSYYCTCPVGFVLLPDGKRC 395
Score = 50.4 bits (115), Expect = 6e-05
Identities = 81/328 (24%), Positives = 140/328 (42%), Gaps = 30/328 (9%)
Query: 736 HTKSISTVN-KNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESKK 794
H SI ++ + T V AG++V MD H EK + + DL + L+
Sbjct: 52 HGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYN------EKRIYWV---DLERQLLQRVF 102
Query: 795 PIDSL-DMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIW 853
S + V +E S +A++W + + W++ ++ I + G++ ++ S L +
Sbjct: 103 LNGSRQERVCNIEKNVSGMAINWINEE--VIWSNQQEGIITVTDMKGNNSHILL-SALKY 159
Query: 854 PAGLAFDWITDKIYWTDGGTNRIEVSKSDG-SMRTLLAWDHIDKPRDIVVNPEGGVMYWS 912
PA +A D + I+W+ + + DG ++ LL + +K + ++ ++W
Sbjct: 160 PANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALL--ETSEKITAVSLDVLDKRLFWI 217
Query: 913 DW---GASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLD 969
+ G++ I D DGG+ I T N A+ L +RI+++ KTI AN
Sbjct: 218 QYNREGSNSLICSCDYDGGSVH--ISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKH 275
Query: 970 GTGRTKLIENLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTLGCGKNNGGCSH- 1028
TG+ + NL F + L +V + A DT + L C G CS
Sbjct: 276 -TGKDMVRINLHSSF-VPLGELKVV----HPLAQPKAEDDTWEPEQKL-CKLRKGNCSST 328
Query: 1029 LCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
+C C C G L++D K C D
Sbjct: 329 VCGQDLQSHLCMCAEGYALSRDRKYCED 356
Score = 42.3 bits (95), Expect = 0.015
Identities = 25/54 (46%), Positives = 26/54 (48%), Gaps = 6/54 (11%)
Query: 451 AACACPMGFLLAEDKYSCRDIDECMYEQDPVC---SQTCSNTVGSFRCGCMTGY 501
A C C GF A D C DIDEC PVC S C NT G + C C GY
Sbjct: 853 ATCQCLKGF--AGDGKLCSDIDECEMGV-PVCPPASSKCINTEGGYVCRCSEGY 903
Score = 37.9 bits (84), Expect = 0.33
Identities = 16/36 (44%), Positives = 18/36 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C N GC+ C PG C CP+G L DGK C
Sbjct: 360 CAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRC 395
Score = 36.7 bits (81), Expect = 0.76
Identities = 21/57 (36%), Positives = 27/57 (47%), Gaps = 6/57 (10%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ--TCSNTVGSFRCGC 497
CI T G+ C C G+ D C DIDEC C + +C+NT G + C C
Sbjct: 888 CINTEGGYV-CRCSEGY--QGDGIHCLDIDECQLGVHS-CGENASCTNTEGGYTCMC 940
>AY506357-1|AAR84237.1| 1152|Homo sapiens truncated epidermal growth
factor (beta-urogastrone) protein.
Length = 1152
Score = 229 bits (561), Expect = 5e-59
Identities = 119/338 (35%), Positives = 181/338 (53%), Gaps = 11/338 (3%)
Query: 418 CPRG----DDEERCPLKRKCSAE-EKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDID 472
CP G D +RC C +C C+ T +G C CP G +L D +C
Sbjct: 382 CPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEG-PLCFCPEGSVLERDGKTCSG-- 438
Query: 473 ECMYEQDPVCSQTCSN-TVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVW 531
C + CSQ C + S+ C C GY L+ DE+SC +G P LLF+N IR +
Sbjct: 439 -CSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMH 497
Query: 532 LTGDNYMSVVKGLHNAV-ALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETP 590
G +Y +++ V ALD+ + ++++ L+ I A M+ +I G++ P
Sbjct: 498 FDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVP 557
Query: 591 AGVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDW 650
G+AVDWI +WTD G + + L+G + ++ ++ +PR IAVHP +FWTD
Sbjct: 558 EGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDT 617
Query: 651 GPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRR 710
G NP+IE + + G R + ++ WP+G+TID+ K+YW DAK VIE A DG RR
Sbjct: 618 GINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRR 677
Query: 711 KVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTG 748
++T + HPFA+ +F+D ++++DW S+ VNK TG
Sbjct: 678 RLTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTG 715
Score = 199 bits (485), Expect = 8e-50
Identities = 111/333 (33%), Positives = 179/333 (53%), Gaps = 12/333 (3%)
Query: 1325 DNGGCSHLCLR-SPLGYTCACPTGMPFEKSTTDQTPKKCK-SHPEEFLIFATRGSITYIS 1382
DNGGCS LC+ SP+ + C C G + D+ K C S P+ FL+FA I ++
Sbjct: 443 DNGGCSQLCVPLSPVSWECDCFPGYDLQ---LDE--KSCAASGPQPFLLFANSQDIRHMH 497
Query: 1383 LESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKL 1442
+ + TL +++ A+D+ I++ L I NM S+ + +I + +
Sbjct: 498 FDGTDYG--TLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDG-SQRERLIEEGV 554
Query: 1443 ETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLIT-GLTEPRALALFPAKGYLYW 1501
+ P GL VDWI YWTD +I + L+G K++ +++PR +A+ P L+W
Sbjct: 555 DVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFW 614
Query: 1502 SDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQ 1561
+D G +P IE S L G R +I DL +P+G+TID+ +LYW DA + I+ ++L+G
Sbjct: 615 TDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGS 674
Query: 1562 HRVQLVP-DAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAV 1620
R +L D +PF + F+DY++++DW S+IR +KRTGK+ ++ ++ + V
Sbjct: 675 KRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVRLQGSMLKPSSLVVV 734
Query: 1621 SADRQHGWNPCKESNGGCSHLCLFRGHEYICAC 1653
+ G +PC NGGC H+C R C+C
Sbjct: 735 HPLAKPGADPCLYQNGGCEHICKKRLGTAWCSC 767
Score = 191 bits (465), Expect = 2e-47
Identities = 108/346 (31%), Positives = 180/346 (52%), Gaps = 9/346 (2%)
Query: 1018 GCGK-NNGGCSHLCL-LKPGGRSCACPIGIKLNKDGKTCA-DGPINYLIFAHRVDIRVIS 1074
GC +NGGCS LC+ L P C C G L D K+CA GP +L+FA+ DIR +
Sbjct: 438 GCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMH 497
Query: 1075 LDVPYLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLH 1134
D ++ + AL D D IY+ T + I+RA G+ E +I G+
Sbjct: 498 FDGTDYGTLLSQQMGMVYAL--DHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVD 555
Query: 1135 TADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWS 1194
+G+ +D GR+ YWTD G++ I ++L+G+ K++ + PR IA+H +FW+
Sbjct: 556 VPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWT 615
Query: 1195 DWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHD 1254
D G + +IE + + G R VI + + WP+G+ ID + +LYW DAK IE ++ DG
Sbjct: 616 DTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSK 675
Query: 1255 RRTVLSN-VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAIQ 1313
RR + N V +P+ + + +++++DW ++ R +K D + ++ ++ + +
Sbjct: 676 RRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVRLQGSMLKPSSLVVVH 735
Query: 1314 S-ERVLENACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQT 1358
+ + C NGGC H+C + C+C G F K++ +T
Sbjct: 736 PLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREG--FMKASDGKT 779
Score = 171 bits (417), Expect = 1e-41
Identities = 103/342 (30%), Positives = 166/342 (48%), Gaps = 31/342 (9%)
Query: 762 MDIHSRSCEET-PEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKS 820
+ + +SC + P+ LL+A +D+R + L + + ALD D
Sbjct: 469 LQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLS-----QQMGMVYALDHDPVE 523
Query: 821 NSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSK 880
N I++ I RA ++GS + +++ + P GLA DWI + YWTD G + I S
Sbjct: 524 NKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSD 583
Query: 881 SDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTW 940
+G ++ ++I +PR I V+P ++W+D G +P IE + + G R + + W
Sbjct: 584 LNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIW 643
Query: 941 PNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIEN-LPHPFGLDLYGDEVFWTDWD 999
P+G+ +D + +++YW D IE ANLDG+ R +L +N + HPF + ++ D V+++DW
Sbjct: 644 PSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWA 703
Query: 1000 TQSIQAANKDTGAKR-RTLG---------------------CGKNNGGCSHLCLLKPGGR 1037
S+ NK TG R R G C NGGC H+C + G
Sbjct: 704 MPSVIRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTA 763
Query: 1038 SCACPIGIKLNKDGKTCADGPINYLIFAHRVDIR--VISLDV 1077
C+C G DGKTC + L+ VD++ V LD+
Sbjct: 764 WCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDI 805
Score = 101 bits (243), Expect = 2e-20
Identities = 79/279 (28%), Positives = 122/279 (43%), Gaps = 13/279 (4%)
Query: 1017 LGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCA--DGPINYLIFAHRVDIRVIS 1074
+ C +N CSH C+L G C CP G L +DGKTC+ P N V + +S
Sbjct: 399 VSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVS 458
Query: 1075 LDVPYLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLH 1134
+ L L A L++ + I+ GT T++ +
Sbjct: 459 WECDCFPGYDLQLDEKSCAAS---GPQPFLLF---ANSQDIRHMHFDGTDYGTLLSQQMG 512
Query: 1135 TADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWS 1194
+ D KIY+ IE A +DG R+ L+ G+D P +A+ + +W+
Sbjct: 513 MVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWT 572
Query: 1195 DWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKI-LTIESSDFDGH 1253
D G S I R+D++G ++I I P G+A+ + RL+W D I IESS G
Sbjct: 573 DRGKSL-IGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGL 631
Query: 1254 DRRTVL-SNVPYPYGIVI--VGQHIYWTDWKTKALHRAD 1289
R + S++ +P GI I + +YW D K + A+
Sbjct: 632 GRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMAN 670
Score = 99.1 bits (236), Expect = 1e-19
Identities = 74/309 (23%), Positives = 146/309 (47%), Gaps = 28/309 (9%)
Query: 1366 PEEFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRS 1425
P FLIF+ SI I E + V + ++ +D+H++ K I++ DL+ +++
Sbjct: 44 PAPFLIFSHGNSIFRIDTEGTNYEQL---VVDAGVSVIMDFHYNEKRIYWVDLERQLLQR 100
Query: 1426 INMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITGLT 1485
+ + + + +K +G+ ++WI + W++ + +I V + G++ +L++ L
Sbjct: 101 VFLNGSRQERVCNIEK--NVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSALK 158
Query: 1486 EPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYW 1545
P +A+ P + +++WS + R+ LDG + +++ +++D ++RL+W
Sbjct: 159 YPANVAVDPVERFIFWSS-EVAGSLYRADLDGVGVKALLETSEKI-TAVSLDVLDKRLFW 216
Query: 1546 ----TDALKDRIDTSDLN-GQHRVQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRT 1600
+ I + D + G + P N F M+ F D I+++ W K+I A+K T
Sbjct: 217 IQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHT 276
Query: 1601 GKNITLIRTNLEMAM----EIKAVSADRQ-----HGWNP----CKESNGGCSH-LCLFRG 1646
GK+ ++R NL + E+K V Q W P CK G CS +C
Sbjct: 277 GKD--MVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDL 334
Query: 1647 HEYICACPD 1655
++C C +
Sbjct: 335 QSHLCMCAE 343
Score = 93.5 bits (222), Expect = 6e-18
Identities = 60/256 (23%), Positives = 124/256 (48%), Gaps = 10/256 (3%)
Query: 497 CMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEK 556
C G + +C G +P L+FS+ I ++ G NY +V +V +D+HY +
Sbjct: 28 CPEGTLAGNGNSTC--VGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYNE 85
Query: 557 KLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVAT 616
K ++W + ++++ +N V + +G+A++WI++ + W++ + V
Sbjct: 86 KRIYWVDLERQLLQRVFLNGSRQERVCNIE-KNVSGMAINWINEEVIWSNQQEGIITVTD 144
Query: 617 LDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFW 676
+ G+ +L+ + L P +AV P + +FW+ + RAD+DG K ++ +
Sbjct: 145 MKGNNSHILL-SALKYPANVAVDPVERFIFWSSEVAG-SLYRADLDGVGVKALL-ETSEK 201
Query: 677 PNGLTIDYTESKIYW----ADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYW 732
+++D + +++W + + +I +DG + FA++LF D I++
Sbjct: 202 ITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFY 261
Query: 733 TDWHTKSISTVNKNTG 748
+ W K+I NK+TG
Sbjct: 262 STWKMKTIWIANKHTG 277
Score = 92.7 bits (220), Expect = 1e-17
Identities = 58/209 (27%), Positives = 108/209 (51%), Gaps = 15/209 (7%)
Query: 811 AVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTI--VDSNLIWPAGLAFDWITDKIYW 868
+V +D+ I+W D+E+ + R +LNGS Q + ++ N+ +G+A +WI +++ W
Sbjct: 76 SVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNV---SGMAINWINEEVIW 132
Query: 869 TDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGG 928
++ I V+ G+ +L + P ++ V+P ++WS A + RAD+DG
Sbjct: 133 SNQQEGIITVTDMKGNNSHILL-SALKYPANVAVDPVERFIFWSSEVAG-SLYRADLDGV 190
Query: 929 NRKKLIFGQMTWPNGLALDLVHNRIYW----TDGGNKTIEYANLDGTGRTKLIEN-LPHP 983
K L+ ++LD++ R++W +G N I + DG G + ++ H
Sbjct: 191 GVKALL-ETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDG-GSVHISKHPTQHN 248
Query: 984 -FGLDLYGDEVFWTDWDTQSIQAANKDTG 1011
F + L+GD +F++ W ++I ANK TG
Sbjct: 249 LFAMSLFGDRIFYSTWKMKTIWIANKHTG 277
Score = 87.4 bits (207), Expect = 4e-16
Identities = 80/365 (21%), Positives = 143/365 (39%), Gaps = 11/365 (3%)
Query: 385 EEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSA-EEKCEKLC 443
E +Q C+ ++ S+ + H+C + D + C +C+ C C
Sbjct: 312 EPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGC 371
Query: 444 ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYIL 503
T G C CP+GF+L D C + C CS C T C C G +L
Sbjct: 372 KNT-PGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSE-CSHDCVLTSEGPLCFCPEGSVL 429
Query: 504 RPDERSCKPTGESPTLLFSNR-IGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLVFWS 562
D ++C S + + V D + L + L+F
Sbjct: 430 ERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLF-- 487
Query: 563 ENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSKR 622
N + IR + + ++ + + D + + +++ + + +E A +DGS+R
Sbjct: 488 -ANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQR 546
Query: 623 AVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTI 682
L+ +D P +AV +WTD G + I R+D++G + K + + I P G+ +
Sbjct: 547 ERLIEEGVDVPEGLAVDWIGRRFYWTDRGKS-LIGRSDLNGKRSKIITKENISQPRGIAV 605
Query: 683 DYTESKIYWADAK-HHVIERAAFDGRDRRKVTTKGLPHPFALTL--FDDAIYWTDWHTKS 739
+++W D + IE ++ G R + + L P +T+ D +YW D
Sbjct: 606 HPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSV 665
Query: 740 ISTVN 744
I N
Sbjct: 666 IEMAN 670
Score = 80.2 bits (189), Expect = 6e-14
Identities = 65/269 (24%), Positives = 121/269 (44%), Gaps = 15/269 (5%)
Query: 1040 ACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISLDVPYLIDVVLPLPPLKNALGVDVD 1099
+CP G TC GP +LIF+H I I + +V+ ++ +D
Sbjct: 27 SCPEGTLAGNGNSTCV-GPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGV---SVIMDFH 82
Query: 1100 HSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIE 1159
++ IYW D ++ +QR G+ E V N G+ I+ ++ W++ I
Sbjct: 83 YNEKRIYWVDLERQLLQRVFLNGSRQERVC-NIEKNVSGMAINWINEEVIWSNQQEGIIT 141
Query: 1160 VAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNK 1219
V ++ G N +L+ + L P +A+ ++FWS + + RAD+DG + +++
Sbjct: 142 VTDMKGNNSHILL-SALKYPANVAVDPVERFIFWSS-EVAGSLYRADLDGVGVKALLETS 199
Query: 1220 IKWPNGLAIDRIEGRLYW----NDAKILTIESSDFDGHDRRTVLSNVPYP-YGIVIVGQH 1274
K +++D ++ RL+W + I S D+DG + + + + G
Sbjct: 200 EK-ITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDR 258
Query: 1275 IYWTDWKTKALHRADKTNASDPIVIRKNL 1303
I+++ WK K + A+K D ++R NL
Sbjct: 259 IFYSTWKMKTIWIANKHTGKD--MVRINL 285
Score = 62.1 bits (144), Expect = 2e-08
Identities = 29/94 (30%), Positives = 47/94 (50%), Gaps = 4/94 (4%)
Query: 419 PRGDDEERCPLKRKCSAEE-KCEK-LCITTYDGHAACACPMGFLLAEDKYSCRDIDECMY 476
P+ +D+ P ++ C + C +C H C C G+ L+ D+ C D++EC +
Sbjct: 304 PKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHL-CMCAEGYALSRDRKYCEDVNECAF 362
Query: 477 EQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSC 510
C+ C NT GS+ C C G++L PD + C
Sbjct: 363 WNHG-CTLGCKNTPGSYYCTCPVGFVLLPDGKRC 395
Score = 50.4 bits (115), Expect = 6e-05
Identities = 81/328 (24%), Positives = 140/328 (42%), Gaps = 30/328 (9%)
Query: 736 HTKSISTVN-KNTGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESKK 794
H SI ++ + T V AG++V MD H EK + + DL + L+
Sbjct: 52 HGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYN------EKRIYWV---DLERQLLQRVF 102
Query: 795 PIDSL-DMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIW 853
S + V +E S +A++W + + W++ ++ I + G++ ++ S L +
Sbjct: 103 LNGSRQERVCNIEKNVSGMAINWINEE--VIWSNQQEGIITVTDMKGNNSHILL-SALKY 159
Query: 854 PAGLAFDWITDKIYWTDGGTNRIEVSKSDG-SMRTLLAWDHIDKPRDIVVNPEGGVMYWS 912
PA +A D + I+W+ + + DG ++ LL + +K + ++ ++W
Sbjct: 160 PANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALL--ETSEKITAVSLDVLDKRLFWI 217
Query: 913 DW---GASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLD 969
+ G++ I D DGG+ I T N A+ L +RI+++ KTI AN
Sbjct: 218 QYNREGSNSLICSCDYDGGSVH--ISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKH 275
Query: 970 GTGRTKLIENLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTLGCGKNNGGCSH- 1028
TG+ + NL F + L +V + A DT + L C G CS
Sbjct: 276 -TGKDMVRINLHSSF-VPLGELKVV----HPLAQPKAEDDTWEPEQKL-CKLRKGNCSST 328
Query: 1029 LCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
+C C C G L++D K C D
Sbjct: 329 VCGQDLQSHLCMCAEGYALSRDRKYCED 356
Score = 42.3 bits (95), Expect = 0.015
Identities = 25/54 (46%), Positives = 26/54 (48%), Gaps = 6/54 (11%)
Query: 451 AACACPMGFLLAEDKYSCRDIDECMYEQDPVC---SQTCSNTVGSFRCGCMTGY 501
A C C GF A D C DIDEC PVC S C NT G + C C GY
Sbjct: 853 ATCQCLKGF--AGDGKLCSDIDECEMGV-PVCPPASSKCINTEGGYVCRCSEGY 903
Score = 37.9 bits (84), Expect = 0.33
Identities = 16/36 (44%), Positives = 18/36 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C N GC+ C PG C CP+G L DGK C
Sbjct: 360 CAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRC 395
Score = 36.7 bits (81), Expect = 0.76
Identities = 21/57 (36%), Positives = 27/57 (47%), Gaps = 6/57 (10%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ--TCSNTVGSFRCGC 497
CI T G+ C C G+ D C DIDEC C + +C+NT G + C C
Sbjct: 888 CINTEGGYV-CRCSEGY--QGDGIHCLDIDECQLGVHS-CGENASCTNTEGGYTCMC 940
>BC021204-1|AAH21204.1| 439|Homo sapiens LRP1 protein protein.
Length = 439
Score = 225 bits (549), Expect = 1e-57
Identities = 128/386 (33%), Positives = 191/386 (49%), Gaps = 23/386 (5%)
Query: 344 RNCSLDEYTCADR-RCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAF 402
+ CS ++ C D+ C+ K W CDG RDC +G DE E+ + C+P EH
Sbjct: 25 KTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAP-EICPQSKAQRCQPNEHNCLGT- 82
Query: 403 RNCVNRKHVCDGMKDCPRGDDE-ERC-PLKRKCSAEEKCEKLCITTYDGHAACACPMGFL 460
CV +C+G++DC G DE C L+ CS C+ C+ T DG C C F
Sbjct: 83 ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCS-RLGCQHHCVPTLDG-PTCYCNSSFQ 140
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCK----PTGES 516
L D +C+D DEC CSQ C+NT GSF CGC+ GY+L+PD RSCK P
Sbjct: 141 LQADGKTCKDFDECSVYG--TCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRP 198
Query: 517 PTLLFSNRIGIRQVWLTGDNYMSVVK-GLHNAVALDYHYEKKLVFW-------SENNLRV 568
P LL +N I +L+G ++ A+D+ Y + V W ++ L+
Sbjct: 199 PVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKC 258
Query: 569 IRVAQMN--TKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLV 626
R+ + + I L +A+DW+ ++ D R+ V +G L+
Sbjct: 259 ARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLL 318
Query: 627 ANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTE 686
+L P+ IA+ P VF+TD+G PK+ER DMDG R ++ +I +P+G+T+D
Sbjct: 319 DLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVS 378
Query: 687 SKIYWADAKHHVIERAAFDGRDRRKV 712
+YWADA IE ++G+ R+ +
Sbjct: 379 RLVYWADAYLDYIEVVDYEGKGRQTI 404
Score = 114 bits (275), Expect = 2e-24
Identities = 109/394 (27%), Positives = 160/394 (40%), Gaps = 36/394 (9%)
Query: 301 PGSCNAGEFKCNDG-KCIPERWRCDNERDCADGGDELN--CKPNSIRNCSLDEYTC-ADR 356
P +C+ +F C D CI + WRCD ERDC DG DE C + + C +E+ C
Sbjct: 24 PKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTE 83
Query: 357 RCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKH--VCDG 414
CV + LC+GV+DC +G DE C E Q C +CV C
Sbjct: 84 LCVPMSRLCNGVQDCMDGSDE---GPHCRELQGNCS-----RLGCQHHCVPTLDGPTCYC 135
Query: 415 MKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
D + C +CS C +LC T DG C C G+LL D SC+ +E
Sbjct: 136 NSSFQLQADGKTCKDFDECSVYGTCSQLCTNT-DGSFICGCVEGYLLQPDNRSCKAKNEP 194
Query: 475 MYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGES---PTLLFSNRIG--IRQ 529
+ + N + ++ G I R S T+ + + +G Q
Sbjct: 195 VDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVH-VGDSAAQ 253
Query: 530 VWLTGDNYMSVVKGLHNAVALD-----YHYEKKLVFWSENNLRVI-----RVAQMNTKNM 579
L M +KG + ++ +H E+ + W N + R+ N
Sbjct: 254 TQLKCAR-MPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGD 312
Query: 580 SDVIRWGLE--TPAGVAVDWIHDLLFWTDSG-TRRVEVATLDGSKRAVLVANDLDKPRAI 636
+ V LE P G+A+D +F+TD G +VE +DG R LV + + P I
Sbjct: 313 TCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGI 372
Query: 637 AVHPGDALVFWTDWGPNPKIERADMDGDKRKTVI 670
+ LV+W D IE D +G R+T+I
Sbjct: 373 TLDLVSRLVYWAD-AYLDYIEVVDYEGKGRQTII 405
Score = 103 bits (248), Expect = 4e-21
Identities = 73/253 (28%), Positives = 118/253 (46%), Gaps = 16/253 (6%)
Query: 1024 GGCSHLCLLKPGGRSCACPIGIKLNKDGKTCA--DGPIN---YLIFAHRVDIRVISLDVP 1078
G CS LC G C C G L D ++C + P++ L+ A+ +I L
Sbjct: 158 GTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGA 217
Query: 1079 YLIDVVLPLPPLKNALGVDVDHSTGLIYWTDTG------QRKIQRATRLGTHVE--TV-I 1129
+ + P + +D ++ + W G Q K R L V+ T+ I
Sbjct: 218 Q-VSTITPTST-RQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINI 275
Query: 1130 GNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYG 1189
LH + + ID Y+ D + I V +G L+ L +P+ IAL G
Sbjct: 276 SLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMG 335
Query: 1190 YMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSD 1249
+F++D+G K+ER DMDG NR +VD+KI +P+G+ +D + +YW DA + IE D
Sbjct: 336 KVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVD 395
Query: 1250 FDGHDRRTVLSNV 1262
++G R+T++ +
Sbjct: 396 YEGKGRQTIIQGI 408
Score = 98.7 bits (235), Expect = 2e-19
Identities = 68/253 (26%), Positives = 115/253 (45%), Gaps = 17/253 (6%)
Query: 1327 GGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEE---FLIFATRGSITYISL 1383
G CS LC + + C C G + D K K+ P + L+ A +I L
Sbjct: 158 GTCSQLCTNTDGSFICGCVEGYLLQP---DNRSCKAKNEPVDRPPVLLIANSQNILATYL 214
Query: 1384 ESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDL-------DLNVIRSINMTNMSESKT 1436
+ +T P + T A+D+ + + + + + L R + + T
Sbjct: 215 SGAQVSTIT-PTS-TRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHT 272
Query: 1437 I-ISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLIT-GLTEPRALALFP 1494
I IS L + +DW+ N Y+ D+ I V +G + L+ L P+ +AL P
Sbjct: 273 INISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDP 332
Query: 1495 AKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRID 1554
A G ++++D+G+ P +ER +DG R +V + FP+G+T+D R +YW DA D I+
Sbjct: 333 AMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIE 392
Query: 1555 TSDLNGQHRVQLV 1567
D G+ R ++
Sbjct: 393 VVDYEGKGRQTII 405
Score = 93.9 bits (223), Expect = 5e-18
Identities = 43/124 (34%), Positives = 70/124 (56%)
Query: 857 LAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGA 916
+A DW+T Y+ D +RI V +G L + P+ I ++P G ++++D+G
Sbjct: 285 MAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQ 344
Query: 917 SPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKL 976
P +ER DMDG NR KL+ ++ +P+G+ LDLV +YW D IE + +G GR +
Sbjct: 345 IPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTI 404
Query: 977 IENL 980
I+ +
Sbjct: 405 IQGI 408
Score = 56.4 bits (130), Expect = 9e-07
Identities = 27/78 (34%), Positives = 39/78 (50%), Gaps = 5/78 (6%)
Query: 263 CAEIDFECKNT-KCVPKDFQCDGDNDCGDWTDE--DSCPMVPGS-CNAGEFKC-NDGKCI 317
C+ F C++ C+ K ++CDG+ DC D +DE + CP C E C C+
Sbjct: 27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCV 86
Query: 318 PERWRCDNERDCADGGDE 335
P C+ +DC DG DE
Sbjct: 87 PMSRLCNGVQDCMDGSDE 104
Score = 54.8 bits (126), Expect = 3e-06
Identities = 40/126 (31%), Positives = 60/126 (47%), Gaps = 4/126 (3%)
Query: 812 VALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTD- 870
+A+DW N F D++ D I NG T++D L P G+A D K+++TD
Sbjct: 285 MAIDW-LTGNFYFVDDID-DRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDY 342
Query: 871 GGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNR 930
G ++E DG RT L I P I ++ ++YW+D IE D +G R
Sbjct: 343 GQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWAD-AYLDYIEVVDYEGKGR 401
Query: 931 KKLIFG 936
+ +I G
Sbjct: 402 QTIIQG 407
Score = 54.0 bits (124), Expect = 5e-06
Identities = 60/287 (20%), Positives = 112/287 (39%), Gaps = 20/287 (6%)
Query: 1009 DTGAKRRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD-GPINYLIFAHR 1067
D G R L + GC H C+ G +C C +L DGKTC D + +
Sbjct: 103 DEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQ 162
Query: 1068 VDIRVISLDVPYLIDVVLPLPPLKN--ALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHV 1125
+ + ++ L P ++ A VD L+ + I G V
Sbjct: 163 LCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLI---ANSQNILATYLSGAQV 219
Query: 1126 ETVIGNGLHTADGIVIDSTGRKIYWTDGG----RNSIEVAELDG-----RNRKVLVWTGL 1176
T+ + + W G + ++ A + G + + L
Sbjct: 220 STITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISLSL 279
Query: 1177 DSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLY 1236
+A+ + G ++ D +I + +G+ ++D ++ P G+A+D G+++
Sbjct: 280 HHVEQMAIDWLTGNFYFVD-DIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVF 338
Query: 1237 WND-AKILTIESSDFDGHDR-RTVLSNVPYPYGIV--IVGQHIYWTD 1279
+ D +I +E D DG +R + V S + +P+GI +V + +YW D
Sbjct: 339 FTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWAD 385
Score = 50.0 bits (114), Expect = 8e-05
Identities = 30/102 (29%), Positives = 51/102 (50%), Gaps = 4/102 (3%)
Query: 662 DGDKRKTVIYDEIFWPNGLTIDYTESKIYWAD-AKHHVIERAAFDGRDRRKVTTKGL--P 718
+GD T++ E++ P G+ +D K+++ D + +ER DG++R K+ + P
Sbjct: 310 NGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFP 369
Query: 719 HPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNV 760
H L L +YW D + I V+ G G QT+ G+ V
Sbjct: 370 HGITLDLVSRLVYWADAYLDYIEVVDYE-GKGRQTIIQGILV 410
Score = 49.2 bits (112), Expect = 1e-04
Identities = 44/194 (22%), Positives = 84/194 (43%), Gaps = 15/194 (7%)
Query: 837 YLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAW--DH- 893
YL+G+ +TI ++ + F + + + W G + + M L + +H
Sbjct: 213 YLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHT 272
Query: 894 ------IDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALD 947
+ + ++ G Y+ D I + +G L+ ++ P G+ALD
Sbjct: 273 INISLSLHHVEQMAIDWLTGNFYFVD-DIDDRIFVCNRNGDTCVTLLDLELYNPKGIALD 331
Query: 948 LVHNRIYWTDGGN-KTIEYANLDGTGRTKLIEN---LPHPFGLDLYGDEVFWTDWDTQSI 1003
++++TD G +E ++DG RTKL+++ PH LDL V+W D I
Sbjct: 332 PAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYI 391
Query: 1004 QAANKDTGAKRRTL 1017
+ + + G R+T+
Sbjct: 392 EVVDYE-GKGRQTI 404
Score = 43.2 bits (97), Expect = 0.009
Identities = 24/95 (25%), Positives = 47/95 (49%), Gaps = 2/95 (2%)
Query: 1391 VTLPVKEVKNTIAVDYHWDLKMIFYTDL-DLNVIRSINMTNMSESKTIISQKLETPNGLG 1449
VTL E+ N + + +F+TD + + +M + +K ++ K+ P+G+
Sbjct: 315 VTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTK-LVDSKIVFPHGIT 373
Query: 1450 VDWIANNIYWTDNEHKVIEVARLDGSSRKVLITGL 1484
+D ++ +YW D IEV +G R+ +I G+
Sbjct: 374 LDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGI 408
Score = 35.5 bits (78), Expect = 1.7
Identities = 13/26 (50%), Positives = 15/26 (57%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDE 192
C CI+ W CDG+ DC D SDE
Sbjct: 34 CRDQITCISKGWRCDGERDCPDGSDE 59
>AB208822-1|BAD92059.1| 555|Homo sapiens Very low-density
lipoprotein receptor precursor variant protein.
Length = 555
Score = 219 bits (534), Expect = 1e-55
Identities = 135/427 (31%), Positives = 207/427 (48%), Gaps = 57/427 (13%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
R+C HE HST CI + W CDG+ND CD S N G+
Sbjct: 168 RTCRIHEISCGAHSTQ-CIPVSWRCDGEND---------CD---------SGEDEENCGN 208
Query: 216 VITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELM--RCAEIDFECKNT 273
+ +P + + ++ + N + S + ++ C +F+C +
Sbjct: 209 ITCSPDEFTCSSGRCI--------SRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTS 260
Query: 274 KCVPKDFQCDGDNDCGDWTDE--DSC---PMVPGSCNAGEFKCNDGKCIPERWRCDNERD 328
C+P + CD D DC D +DE + C P++ C A E +C G+CI ++WRCD + D
Sbjct: 261 SCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPD 320
Query: 329 CADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV--SC-E 385
C DG DE+NC P+ R C D++ C D C+ + C+G+RDC +G DE+NC+ C
Sbjct: 321 CKDGSDEVNC-PS--RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLG 377
Query: 386 EDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE--ERCPLKRKCSAEEKCEKLC 443
++ CR E C++ VC+ +DC DE + C + C +C
Sbjct: 378 PGKFKCRSGE---------CIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHIC 428
Query: 444 ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQTCSNTVGSFRCGCMTGYI 502
G+ C C GF L D+ +C DIDEC Q+P +CSQ C N G ++C C GY
Sbjct: 429 KDLVIGYE-CDCAAGFELI-DRKTCGDIDEC---QNPGICSQICINLKGGYKCECSRGYQ 483
Query: 503 LRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYHYEKKLVFWS 562
+ CK G+ P+L+F+NR IR++ L Y+ +V+ L N VALD + +FW+
Sbjct: 484 MDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWA 543
Query: 563 ENNLRVI 569
+ + + I
Sbjct: 544 DLSQKAI 550
Score = 151 bits (365), Expect = 3e-35
Identities = 68/179 (37%), Positives = 100/179 (55%), Gaps = 16/179 (8%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
+C F+C N +C+ ++CDGD DC D +DE +C V +C +F CN+G+C+P RW
Sbjct: 89 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC--VKKTCAESDFVCNNGQCVPSRW 146
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCA--DRRCVLKTWLCDGVRDCTNGEDEMN 379
+CD + DC DG DE + + +R C + E +C +C+ +W CDG DC +GEDE N
Sbjct: 147 KCDGDPDCEDGSDE-SPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEEN 205
Query: 380 C-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE 437
C ++C D++TC + C++R VC+G DC G DE C C A E
Sbjct: 206 CGNITCSPDEFTC---------SSGRCISRNFVCNGQDDCSDGSDELDC-APPTCGAHE 254
Score = 150 bits (363), Expect = 5e-35
Identities = 100/361 (27%), Positives = 154/361 (42%), Gaps = 32/361 (8%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C+ +F C + +C+ ++F C+G +DC D +DE C P +C A EF+C+ CIP W
Sbjct: 211 CSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDC--APPTCGAHEFQCSTSSCIPISWV 268
Query: 323 CDNERDCADGGDEL--NC--KPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEM 378
CD++ DC+D DE C +P C E C C+ K W CDG DC +G DE+
Sbjct: 269 CDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEV 328
Query: 379 NC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE 437
NC +C DQ+ C +C++ C+G++DC G DE C +C
Sbjct: 329 NCPSRTCRPDQFECED---------GSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPG 379
Query: 438 KCEKLCITTYDGHAACACPMGFLLAEDK--YSCRDIDECMYEQDPVCSQTCSNTVGSFRC 495
K + D C D+ C I+EC+ CS C + V + C
Sbjct: 380 KFKCRSGECIDISKVCNQEQDCRDWSDEPLKECH-INECLVNNGG-CSHICKDLVIGYEC 437
Query: 496 GCMTGYILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDNYMSVVKG----LHNAVALD 551
C G+ L D ++C E ++I I L G +G L V
Sbjct: 438 DCAAGFEL-IDRKTCGDIDECQNPGICSQICIN---LKGGYKCECSRGYQMDLATGVCKA 493
Query: 552 YHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRR 611
E L+F + ++R I + + + + +R + A +A LFW D +
Sbjct: 494 VGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA----QKLFWADLSQKA 549
Query: 612 V 612
+
Sbjct: 550 I 550
Score = 54.0 bits (124), Expect = 5e-06
Identities = 32/96 (33%), Positives = 48/96 (50%), Gaps = 4/96 (4%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGPINYLIFAHRVDIRVISLDVPY 1079
+N G CS +C+ GG C C G +++ C A G LIF +R DIR I L+
Sbjct: 458 QNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKE 517
Query: 1080 LIDVVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKI 1115
I +V L+N + +D D + ++W D Q+ I
Sbjct: 518 YIQLV---EQLRNTVALDADIAAQKLFWADLSQKAI 550
Score = 45.6 bits (103), Expect = 0.002
Identities = 32/100 (32%), Positives = 47/100 (47%), Gaps = 9/100 (9%)
Query: 1327 GGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKS-HPEEFLIFATRGSITYISLES 1385
G CS +C+ GY C C G + +T CK+ E LIF R I I LE
Sbjct: 461 GICSQICINLKGGYKCECSRGYQMDLAT-----GVCKAVGKEPSLIFTNRRDIRKIGLER 515
Query: 1386 PEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRS 1425
E + V++++NT+A+D + +F+ DL I S
Sbjct: 516 KEYIQL---VEQLRNTVALDADIAAQKLFWADLSQKAIFS 552
Score = 41.5 bits (93), Expect = 0.027
Identities = 19/28 (67%), Positives = 19/28 (67%), Gaps = 1/28 (3%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKT 200
CI L W CDGD DC D SDE NC V KT
Sbjct: 102 CITLLWKCDGDEDCVDGSDEKNC-VKKT 128
Score = 39.9 bits (89), Expect = 0.081
Identities = 22/61 (36%), Positives = 28/61 (45%), Gaps = 3/61 (4%)
Query: 1290 KTNASDPIVIRKNLEGLMDIRAIQSERVLE---NACGTDNGGCSHLCLRSPLGYTCACPT 1346
K + + I I K D R E + E N C +NGGCSH+C +GY C C
Sbjct: 382 KCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAA 441
Query: 1347 G 1347
G
Sbjct: 442 G 442
Score = 39.9 bits (89), Expect = 0.081
Identities = 19/38 (50%), Positives = 21/38 (55%), Gaps = 1/38 (2%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NNGGCSH+C G C C G +L D KTC D
Sbjct: 417 CLVNNGGCSHICKDLVIGYECDCAAGFEL-IDRKTCGD 453
Score = 37.1 bits (82), Expect = 0.57
Identities = 23/73 (31%), Positives = 38/73 (52%), Gaps = 7/73 (9%)
Query: 762 MDIHSRSCEET-PEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKS 820
MD+ + C+ E L++ R+D+R LE K+ I VE +++ VALD D +
Sbjct: 484 MDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQL------VEQLRNTVALDADIAA 537
Query: 821 NSIFWTDVEKDTI 833
+FW D+ + I
Sbjct: 538 QKLFWADLSQKAI 550
Score = 35.1 bits (77), Expect = 2.3
Identities = 14/31 (45%), Positives = 19/31 (61%), Gaps = 1/31 (3%)
Query: 162 ENRTICHSTNVCIALEWLCDGDNDCGDFSDE 192
E+ +C++ C+ W CDGD DC D SDE
Sbjct: 131 ESDFVCNNGQ-CVPSRWKCDGDPDCEDGSDE 160
>AC068195-1|AAX93243.1| 1126|Homo sapiens unknown protein.
Length = 1126
Score = 214 bits (522), Expect = 3e-54
Identities = 142/504 (28%), Positives = 222/504 (44%), Gaps = 41/504 (8%)
Query: 263 CAEIDFECKN-TKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
C E F CKN C+P + CDG +DC D +DE++C C A EF CN+ C W
Sbjct: 490 CKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHFW 549
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRR-CVLKTWLCDGVRDCTNGEDEMNC 380
CD E DC D DE S + C + R C+ +C+G+ +C + DE +C
Sbjct: 550 VCDGEDDCGDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHC 609
Query: 381 EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC---PLKRKCSAE- 436
C+ E SN + C+ CD + DC G DE+ C P + C
Sbjct: 610 GGKLTYKARPCKKDEFACSN--KKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNV 667
Query: 437 EKC-EKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRC 495
C + C C GF C D++EC+ CS C N GS++C
Sbjct: 668 NPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFG--TCSHQCINVEGSYKC 725
Query: 496 GCMTGYILRPDERSCKPTGESPTLLF----SNRIGIRQVWLTGDNYMSVVKGLHNA--VA 549
C + R +C G +L+ ++ +G + ++ + HN+
Sbjct: 726 VCDQNFQER--NNTCIAEGSEDQVLYIANDTDILGFIYPFNYSGDHQQISHIEHNSRITG 783
Query: 550 LDYHYEKKLVFWSEN-NLRVIRVAQMNTKNM----SDVIRWGLETPAGVAVDWIHDLLFW 604
+D +Y++ ++ WS N I +++ + S +I + P +AVDW+ ++W
Sbjct: 784 MDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFKRPRDIAVDWVAGNIYW 843
Query: 605 TDSGTRR---------------VEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTD 649
TD + V L+G L+ N +P AIAV+P +++WT
Sbjct: 844 TDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTV 903
Query: 650 WGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDR 709
G + IE A MDG R+ ++ + P GL +DY +IYWAD + +I +DG +
Sbjct: 904 VGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDGSNS 963
Query: 710 -RKVTTK-GLPHPFALTLFDDAIY 731
V++K GL HP + +F+D IY
Sbjct: 964 VVSVSSKQGLLHPHRIDIFEDYIY 987
Score = 163 bits (396), Expect = 5e-39
Identities = 83/218 (38%), Positives = 117/218 (53%), Gaps = 19/218 (8%)
Query: 263 CAEIDFECKNTK-CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
C+ F+CK TK C+ K + CD D DC D +DE +C +C EF+C + CIP+ W
Sbjct: 294 CSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKK--TCGPHEFQCKNNNCIPDHW 351
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCE 381
RCD++ DC+D DE NCKP + C+L ++ CA+ CV + CDG DC +G DE NCE
Sbjct: 352 RCDSQNDCSDNSDEENCKP---QTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNCE 408
Query: 382 VSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC-PLKRKCSAEEKCE 440
SC +DQ+ C SN C+ K CDG +DC G+DE+ C P CS+ E
Sbjct: 409 TSCSKDQFRC-------SNG--QCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSR---E 456
Query: 441 KLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQ 478
+C + A+ C + A+ + EC +Q
Sbjct: 457 YICASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQ 494
Score = 140 bits (340), Expect = 3e-32
Identities = 85/256 (33%), Positives = 118/256 (46%), Gaps = 31/256 (12%)
Query: 263 CAEIDFEC-KNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK-CIPER 320
C F+C KN KC+P + +C+G +DCGD DE CP SC+ F+C K CI +
Sbjct: 254 CLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCP--ENSCSPDYFQCKTTKHCISKL 311
Query: 321 WRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC 380
W CD + DCAD DE NC + C E+ C + C+ W CD DC++ DE NC
Sbjct: 312 WVCDEDPDCADASDEANCDK---KTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENC 368
Query: 381 EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE-KC 439
+ TC ++ L +N +CV+ + CDG DC G DE C + CS ++ +C
Sbjct: 369 K------PQTCTLKDFLCANG--DCVSSRFWCDGDFDCADGSDERNC--ETSCSKDQFRC 418
Query: 440 EK-LCITT---YDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC-SQTCSNTVGSFR 494
CI DGH C ED+ SC ++ +C S C + S +
Sbjct: 419 SNGQCIPAKWKCDGHEDCK------YGEDEKSCEPASPTCSSREYICASDGCIS--ASLK 470
Query: 495 CGCMTGYILRPDERSC 510
C DE C
Sbjct: 471 CNGEYDCADGSDEMDC 486
Score = 135 bits (327), Expect = 1e-30
Identities = 71/213 (33%), Positives = 102/213 (47%), Gaps = 24/213 (11%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C++ F C N +C+P ++CDG DC DE SC +C++ E+ C CI +
Sbjct: 411 CSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASDGCISASLK 470
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADR-RCVLKTWLCDGVRDCTNGEDEMNCE 381
C+ E DCADG DE++C + C D++ C ++ C+ WLCDG+ DC +G DE N
Sbjct: 471 CNGEYDCADGSDEMDC----VTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEEN-- 524
Query: 382 VSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEK 441
CE CR E L +N+ C VCDG DC GD+ + P + C K
Sbjct: 525 --CERGGNICRADEFLCNNSL--CKLHFWVCDGEDDC--GDNSDEAP--------DMCVK 570
Query: 442 LCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
+ H C + + + C IDEC
Sbjct: 571 FLCPSTRPH---RCRNNRICLQSEQMCNGIDEC 600
Score = 126 bits (303), Expect = 1e-27
Identities = 65/181 (35%), Positives = 89/181 (49%), Gaps = 17/181 (9%)
Query: 260 LMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDE-DSCPMVPGSCNAGEFKCNDGKCIP 318
L C F CK KC+P ++CD +DCGD +DE D CP C G F+C G C
Sbjct: 172 LSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEF--RCQPGRFQCGTGLCAL 229
Query: 319 ERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCA-DRRCVLKTWLCDGVRDCTNGEDE 377
+ CD E DC D DELNC + C ++ C +++C+ C+G DC + EDE
Sbjct: 230 PAFICDGENDCGDNSDELNCDTHV---CLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDE 286
Query: 378 MNC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAE 436
+C E SC D + C+ +H C+++ VCD DC DE C K+ C
Sbjct: 287 RDCPENSCSPDYFQCKTTKH--------CISKLWVCDEDPDCADASDEANCD-KKTCGPH 337
Query: 437 E 437
E
Sbjct: 338 E 338
Score = 121 bits (292), Expect = 2e-26
Identities = 65/162 (40%), Positives = 92/162 (56%), Gaps = 7/162 (4%)
Query: 1190 YMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSD 1249
Y++W D I R MDG N+ V+++ KI P L ID + RLYW D IE S+
Sbjct: 1 YLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADEN--HIEFSN 58
Query: 1250 FDGHDRRTVLS-NVPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMD 1308
DG R V + ++P + + +IYWTD KTK+L RA KT+ +D + + + + D
Sbjct: 59 MDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITD 118
Query: 1309 IRAIQSER---VLENACGTDNGGCSHLCLRSP-LGYTCACPT 1346
I+ S R V ++ C +NGGCSHLCL +P +TCACPT
Sbjct: 119 IQVYHSYRQPDVSKHLCMINNGGCSHLCLLAPGKTHTCACPT 160
Score = 121 bits (292), Expect = 2e-26
Identities = 64/162 (39%), Positives = 94/162 (58%), Gaps = 8/162 (4%)
Query: 1498 YLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSD 1557
YLYW D E+P+I R +DG+ + ++++ + P LTIDY RRLYW D ++ I+ S+
Sbjct: 1 YLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWAD--ENHIEFSN 58
Query: 1558 LNGQHRVQLVPDAKNP--FGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAM 1615
++G HR VP+ P +T F+DYIYWTD KS+ RA K +G + + +
Sbjct: 59 MDGSHR-HKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAIT 117
Query: 1616 EIKAVSADRQHGWNP--CKESNGGCSHLCLFR-GHEYICACP 1654
+I+ + RQ + C +NGGCSHLCL G + CACP
Sbjct: 118 DIQVYHSYRQPDVSKHLCMINNGGCSHLCLLAPGKTHTCACP 159
Score = 111 bits (268), Expect = 2e-23
Identities = 91/356 (25%), Positives = 150/356 (42%), Gaps = 36/356 (10%)
Query: 1327 GGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSIT---YISL 1383
G CSH C+ Y C C +T + ++ L A I Y
Sbjct: 710 GTCSHQCINVEGSYKCVCDQNFQERNNTCI-----AEGSEDQVLYIANDTDILGFIYPFN 764
Query: 1384 ESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFY-TDLDLNVI---RSINMTNMSESKTIIS 1439
S + ++ ++ +D ++ MI + T + I R + +I
Sbjct: 765 YSGDHQQIS-HIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLIC 823
Query: 1440 QKLETPNGLGVDWIANNIYWTDNEHK---------------VIEVARLDGSSRKVLITGL 1484
+ + P + VDW+A NIYWTD+ I V +L+G + L+T +
Sbjct: 824 PEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNM 883
Query: 1485 T-EPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRL 1543
EP A+A+ P +G +YW+ G+H +IE + +DG+ R+I+VQ +L P GL +DY R+
Sbjct: 884 AGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERI 943
Query: 1544 YWTDALKDRIDTSDLNGQHRVQLVPDAK---NPFGMTQFKDYIYWTDWYKKSIIRADKRT 1600
YW D I + +G + V V + +P + F+DYIY K + R K
Sbjct: 944 YWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAG-PKNGVFRVQKFG 1002
Query: 1601 GKNITLIRTNLEMAMEIKAVSADRQHGW-NPCKESNGGCSHLCLFRGHEYICACPD 1655
++ + N++ + +Q NPC + C LCL C CP+
Sbjct: 1003 HGSVEYLALNIDKTKGVLISHRYKQLDLPNPCLDL--ACEFLCLLNPSGATCVCPE 1056
Score = 105 bits (251), Expect = 2e-21
Identities = 63/172 (36%), Positives = 91/172 (52%), Gaps = 28/172 (16%)
Query: 909 MYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANL 968
+YW D P I R MDG N+ +I +++ P L +D V+ R+YW D + IE++N+
Sbjct: 2 LYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADENH--IEFSNM 59
Query: 969 DGTGRTKL-IENLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTL---------- 1017
DG+ R K+ +++P L L+ D ++WTD T+S+ A+K +GA R +L
Sbjct: 60 DGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDI 119
Query: 1018 --------------GCGKNNGGCSHLCLLKPG-GRSCACPIGIKLNKDGKTC 1054
C NNGGCSHLCLL PG +CACP L D +TC
Sbjct: 120 QVYHSYRQPDVSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTC 171
Score = 101 bits (243), Expect = 2e-20
Identities = 92/351 (26%), Positives = 146/351 (41%), Gaps = 30/351 (8%)
Query: 1024 GGCSHLCLLKPGGRSCACPIGIKLNKDGKTC-ADGPINYLIF-AHRVDIRVISLDVPYLI 1081
G CSH C+ G C C + + TC A+G + +++ A+ DI Y
Sbjct: 710 GTCSHQCINVEGSYKCVCDQNFQ--ERNNTCIAEGSEDQVLYIANDTDILGFIYPFNYSG 767
Query: 1082 D--VVLPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTAD-- 1137
D + + G+DV + +I W+ R+ + +GL +
Sbjct: 768 DHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFK 827
Query: 1138 ---GIVIDSTGRKIYWTDGGRN---------------SIEVAELDGRNRKVLVWTGLDSP 1179
I +D IYWTD R SI V +L+G N L+ P
Sbjct: 828 RPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEP 887
Query: 1180 RAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWND 1239
AIA++ + G M+W+ G + IE A MDG RR++V ++ P GLA+D R+YW D
Sbjct: 888 YAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWAD 947
Query: 1240 AKILTIESSDFDGHDRRTVLSN---VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDP 1296
++ I S +DG + +S+ + +P+ I I +IY K + R K
Sbjct: 948 FELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPK-NGVFRVQKFGHGSV 1006
Query: 1297 IVIRKNLEGLMDIRAIQSERVLENACGTDNGGCSHLCLRSPLGYTCACPTG 1347
+ N++ + + L+ + C LCL +P G TC CP G
Sbjct: 1007 EYLALNIDKTKGVLISHRYKQLDLPNPCLDLACEFLCLLNPSGATCVCPEG 1057
Score = 97.9 bits (233), Expect = 3e-19
Identities = 63/214 (29%), Positives = 88/214 (41%), Gaps = 21/214 (9%)
Query: 303 SCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKT 362
+C A +F+C KCIP W+CD DC DG DE + P C + C C L
Sbjct: 174 NCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEF--RCQPGRFQCGTGLCALPA 231
Query: 363 WLCDGVRDCTNGEDEMNCEVS-CEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRG 421
++CDG DC + DE+NC+ C Q+ C + C+ C+G DC
Sbjct: 232 FICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQ--------KCIPVNLRCNGQDDCGDE 283
Query: 422 DDEERCPLKRKCSAEE---KCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQ 478
+DE CP + CS + K K CI+ C A D+ +C D C +
Sbjct: 284 EDERDCP-ENSCSPDYFQCKTTKHCISKL---WVCDEDPDCADASDEANC-DKKTCGPHE 338
Query: 479 DPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP 512
+ C +RC DE +CKP
Sbjct: 339 FQCKNNNC--IPDHWRCDSQNDCSDNSDEENCKP 370
Score = 95.1 bits (226), Expect = 2e-18
Identities = 47/104 (45%), Positives = 60/104 (57%), Gaps = 2/104 (1%)
Query: 645 VFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAF 704
++W D P I R MDG + VI +I P LTIDY ++YWAD H IE +
Sbjct: 2 LYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADENH--IEFSNM 59
Query: 705 DGRDRRKVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTG 748
DG R KV + +P ALTLF+D IYWTD TKS+S +K +G
Sbjct: 60 DGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSG 103
Score = 89.4 bits (212), Expect = 1e-16
Identities = 104/403 (25%), Positives = 155/403 (38%), Gaps = 72/403 (17%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
++C HE + C + N CI W CD NDC D SDE NC +T L A+ GD
Sbjct: 332 KTCGPHEFQ--CKNNN-CIPDHWRCDSQNDCSDNSDEENCK-PQTCTLKDFLCAN---GD 384
Query: 216 VITNPTVL---IALTKPTVVIRYESFCAKKAL--DNAANPRSTWN-QPVELMRCAEIDFE 269
+++ + E+ C+K N + W E + E +
Sbjct: 385 CVSSRFWCDGDFDCADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKS 444
Query: 270 CK--NTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDG--------KCIPE 319
C+ + C +++ C D C CN GE+ C DG +C +
Sbjct: 445 CEPASPTCSSREYICASD----------GCISASLKCN-GEYDCADGSDEMDCVTECKED 493
Query: 320 RWRCDNE-------------RDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCD 366
++RC N+ DC DG DE NC+ C DE+ C + C L W+CD
Sbjct: 494 QFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGG-NICRADEFLCNNSLCKLHFWVCD 552
Query: 367 GVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEER 426
G DC + DE C ++ C R C+ + +C+G+ +C DE+
Sbjct: 553 GEDDCGDNSDE--APDMCV--KFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDH 608
Query: 427 CPLK-----RKCSAEE-KC-EKLCI------TTYDGHAACACPMGFLLAEDKYSCRD-ID 472
C K R C +E C K CI D + G +A +Y+C D ++
Sbjct: 609 CGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVN 668
Query: 473 ECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C D C+Q + S C C G+ R C+ E
Sbjct: 669 PC--GDDAYCNQIKT----SVFCRCKPGFQRNMKNRQCEDLNE 705
Score = 81.0 bits (191), Expect = 4e-14
Identities = 70/241 (29%), Positives = 96/241 (39%), Gaps = 40/241 (16%)
Query: 854 PAGLAFDWITDKIYWTDGGTNR---------------IEVSKSDGSMRTLLAWDHIDKPR 898
P +A DW+ IYWTD I V + +G T L + +P
Sbjct: 829 PRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPY 888
Query: 899 DIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDG 958
I VNP+ G+MYW+ G IE A MDG R+ L+ + P GLA+D RIYW D
Sbjct: 889 AIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADF 948
Query: 959 GNKTIEYANLDGTGRTKLI---ENLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTGA-KR 1014
I DG+ + + L HP +D++ D ++ + G+ +
Sbjct: 949 ELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKNGVFRVQKFGHGSVEY 1008
Query: 1015 RTLGCGKNNG-------------------GCSHLCLLKPGGRSCACPIGIKLNKDGKTCA 1055
L K G C LCLL P G +C CP G K +G TC
Sbjct: 1009 LALNIDKTKGVLISHRYKQLDLPNPCLDLACEFLCLLNPSGATCVCPEG-KYLING-TCN 1066
Query: 1056 D 1056
D
Sbjct: 1067 D 1067
Score = 79.0 bits (186), Expect = 1e-13
Identities = 74/287 (25%), Positives = 107/287 (37%), Gaps = 36/287 (12%)
Query: 111 DDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTICHST 170
D+ C+T C + F C+ CIP+ R + +
Sbjct: 482 DEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNN 541
Query: 171 NVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPT 230
++C W+CDG++DCGD SDE VK L PS T P
Sbjct: 542 SLCKLHFWVCDGEDDCGDNSDEAPDMCVK--FLCPS-----------TRPH---RCRNNR 585
Query: 231 VVIRYESFC--AKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDC 288
+ ++ E C + DN+ + C + +F C N KC+P D QCD +DC
Sbjct: 586 ICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDC 645
Query: 289 GDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDEL--NCKPNSIRNC 346
GD +DE C + P E+ C D P C ++ C + CKP RN
Sbjct: 646 GDGSDEQGCRIAP-----TEYTCED-NVNP----CGDDAYCNQIKTSVFCRCKPGFQRN- 694
Query: 347 SLDEYTCADRRCVLKTWLCDGVRDCTN--GEDEMNCEVSCEEDQYTC 391
+ C D L C C N G + C+ + +E TC
Sbjct: 695 -MKNRQCEDLNECLVFGTCS--HQCINVEGSYKCVCDQNFQERNNTC 738
Score = 54.8 bits (126), Expect = 3e-06
Identities = 34/115 (29%), Positives = 59/115 (51%), Gaps = 7/115 (6%)
Query: 823 IFWTDV-EKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKS 881
++W D E I R ++G++Q+ ++++ + P L D++ ++YW D N IE S
Sbjct: 2 LYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWAD--ENHIEFSNM 59
Query: 882 DGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERA-DMDGGNRKKLIF 935
DGS R + + D P I + +YW+D G + + RA G +R LI+
Sbjct: 60 DGSHRHKV--PNQDIPGVIALTLFEDYIYWTD-GKTKSLSRAHKTSGADRLSLIY 111
Score = 50.4 bits (115), Expect = 6e-05
Identities = 31/114 (27%), Positives = 57/114 (50%), Gaps = 7/114 (6%)
Query: 1148 IYWTDGGRNS-IEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERAD 1206
+YW D I +DG N+ V++ T + P A+ + Y ++W+D IE ++
Sbjct: 2 LYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWAD---ENHIEFSN 58
Query: 1207 MDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTI-ESSDFDGHDRRTVL 1259
MDG++R + + I P +A+ E +YW D K ++ + G DR +++
Sbjct: 59 MDGSHRHKVPNQDI--PGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLI 110
Score = 50.4 bits (115), Expect = 6e-05
Identities = 31/90 (34%), Positives = 39/90 (43%), Gaps = 8/90 (8%)
Query: 111 DDAGCITP-CLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHE---NRTI 166
D+ C T CL F C + CIP+ R R C E+ +
Sbjct: 245 DELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDE----RDCPENSCSPDYFQ 300
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCD 196
C +T CI+ W+CD D DC D SDE NCD
Sbjct: 301 CKTTKHCISKLWVCDEDPDCADASDEANCD 330
Score = 49.2 bits (112), Expect = 1e-04
Identities = 29/103 (28%), Positives = 52/103 (50%), Gaps = 6/103 (5%)
Query: 1423 IRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLIT 1482
I + M ++S +I K+ P L +D++ +YW D H IE + +DGS R +
Sbjct: 13 IGRVGMDGTNQS-VVIETKISRPMALTIDYVNRRLYWADENH--IEFSNMDGSHRH-KVP 68
Query: 1483 GLTEPRALALFPAKGYLYWSDWGEHPYIERSY-LDGSQRQIIV 1524
P +AL + Y+YW+D G+ + R++ G+ R ++
Sbjct: 69 NQDIPGVIALTLFEDYIYWTD-GKTKSLSRAHKTSGADRLSLI 110
Score = 48.4 bits (110), Expect = 2e-04
Identities = 32/102 (31%), Positives = 48/102 (47%), Gaps = 6/102 (5%)
Query: 1105 IYWTDTGQRK-IQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAEL 1163
+YW D + I R GT+ VI + + ID R++YW D N IE + +
Sbjct: 2 LYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWAD--ENHIEFSNM 59
Query: 1164 DGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERA 1205
DG +R + D P IAL Y++W+D G + + RA
Sbjct: 60 DGSHRHKV--PNQDIPGVIALTLFEDYIYWTD-GKTKSLSRA 98
Score = 47.6 bits (108), Expect = 4e-04
Identities = 26/86 (30%), Positives = 36/86 (41%), Gaps = 2/86 (2%)
Query: 111 DDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTICHST 170
D+ C++ C F C+ CIP + R C T
Sbjct: 167 DNRTCLSNCTASQFRCKTD-KCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQC-GT 224
Query: 171 NVCIALEWLCDGDNDCGDFSDEINCD 196
+C ++CDG+NDCGD SDE+NCD
Sbjct: 225 GLCALPAFICDGENDCGDNSDELNCD 250
Score = 46.4 bits (105), Expect = 0.001
Identities = 29/99 (29%), Positives = 49/99 (49%), Gaps = 6/99 (6%)
Query: 574 MNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKP 633
M+ N S VI + P + +D+++ L+W D +E + +DGS R + D+ P
Sbjct: 18 MDGTNQSVVIETKISRPMALTIDYVNRRLYWADE--NHIEFSNMDGSHRHKVPNQDI--P 73
Query: 634 RAIAVHPGDALVFWTDWGPNPKIERA-DMDGDKRKTVIY 671
IA+ + ++WTD G + RA G R ++IY
Sbjct: 74 GVIALTLFEDYIYWTD-GKTKSLSRAHKTSGADRLSLIY 111
Score = 45.6 bits (103), Expect = 0.002
Identities = 33/131 (25%), Positives = 62/131 (47%), Gaps = 3/131 (2%)
Query: 825 WTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWT-DGGTNRIEVSKSDG 883
WT + + +IN LNG + T ++ + P +A + +YWT G + IE + DG
Sbjct: 859 WTSL-RYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDG 917
Query: 884 SMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPNG 943
++R +L ++ +P + V+ +YW+D+ S I DG N + + +
Sbjct: 918 TLRRILVQKNLQRPTGLAVDYFSERIYWADFELS-IIGSVLYDGSNSVVSVSSKQGLLHP 976
Query: 944 LALDLVHNRIY 954
+D+ + IY
Sbjct: 977 HRIDIFEDYIY 987
Score = 43.6 bits (98), Expect = 0.007
Identities = 24/73 (32%), Positives = 39/73 (53%), Gaps = 1/73 (1%)
Query: 813 ALDWDQKSNSIFWTDV-EKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDG 871
A+ + K ++WT V + I A ++G+ + +V NL P GLA D+ +++IYW D
Sbjct: 889 AIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADF 948
Query: 872 GTNRIEVSKSDGS 884
+ I DGS
Sbjct: 949 ELSIIGSVLYDGS 961
Score = 39.5 bits (88), Expect = 0.11
Identities = 22/85 (25%), Positives = 36/85 (42%), Gaps = 1/85 (1%)
Query: 111 DDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTICHST 170
D+ C T C K F C + CIP + + + +R ++
Sbjct: 403 DERNCETSCSKDQFRCS-NGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICAS 461
Query: 171 NVCIALEWLCDGDNDCGDFSDEINC 195
+ CI+ C+G+ DC D SDE++C
Sbjct: 462 DGCISASLKCNGEYDCADGSDEMDC 486
>AC117947-1|AAX88968.1| 346|Homo sapiens unknown protein.
Length = 346
Score = 199 bits (486), Expect = 6e-50
Identities = 130/353 (36%), Positives = 185/353 (52%), Gaps = 30/353 (8%)
Query: 1105 IYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAELD 1164
IYWTD G KI RA R T E +I NGL +GI +D IYWTD G N IEVA L+
Sbjct: 4 IYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLN 63
Query: 1165 GRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKWPN 1224
G R V++ GLD PR+IA+H E G +FW++WG I +A +DG+ + V+V I WPN
Sbjct: 64 GSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWPN 123
Query: 1225 GLAIDRIEGRLYWNDAKILTIESSDFD-GHDRRTVL--SNVPYPYGIVIVGQHIYWTD-- 1279
G++ID E +LYW DA+ IE D + G +R VL SNV + + + G +IYW+D
Sbjct: 124 GISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDM-FSVAVFGAYIYWSDRA 182
Query: 1280 WKTKALHRADKTNASDPIVIRKNL-EGLMDIRAIQSERVL-ENACGTDNGGCSHLCL-RS 1336
++ R K +A++ I +R L L +++ R N C DNGGC LCL R
Sbjct: 183 HANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLYRG 242
Query: 1337 PLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESPEQWDVTLPVK 1396
TCAC G E T C H E +L+++ R + I L ++ ++ P++
Sbjct: 243 NSRRTCACAHGYLAEDGVT------CLRH-EGYLLYSGRTILKSIHLS--DETNLNSPIR 293
Query: 1397 EVKN--------TIAVDYHWDLK---MIFYTDLDLNVIRSINMTNMSESKTII 1438
+N +A DY+ K IFY+D I+ I N + + I+
Sbjct: 294 PYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNIQLIK-DNWEDRQVIV 345
Score = 194 bits (474), Expect = 2e-48
Identities = 100/248 (40%), Positives = 149/248 (60%), Gaps = 8/248 (3%)
Query: 1413 IFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARL 1472
I++TD+ N I S + + + II+ L G+ VDWIA NIYWTD+ +IEVARL
Sbjct: 4 IYWTDMGFNKI-SRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARL 62
Query: 1473 DGSSRKVLIT-GLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFP 1531
+GS R V+I+ GL +PR++A+ P KG L+W++WG+ P I ++ LDGS++ ++V + + +P
Sbjct: 63 NGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWP 122
Query: 1532 NGLTIDYKERRLYWTDALKDRIDTSDL--NGQHRVQLVPDAKNPFGMTQFKDYIYWTD-- 1587
NG++IDY+E +LYW DA D+I+ DL G + L + F + F YIYW+D
Sbjct: 123 NGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSDRA 182
Query: 1588 WYKKSIIRADKRTGKNITLIRTNLEMAM-EIKAVSADRQHGWNPCKESNGGCSHLCLFRG 1646
S+ R K +RT L + + E+K + R+ G N C NGGC LCL+RG
Sbjct: 183 HANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLYRG 242
Query: 1647 H-EYICAC 1653
+ CAC
Sbjct: 243 NSRRTCAC 250
Score = 161 bits (390), Expect = 3e-38
Identities = 91/284 (32%), Positives = 154/284 (54%), Gaps = 30/284 (10%)
Query: 820 SNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVS 879
+++I+WTD+ + I+RA + + + I+ + L G+A DWI IYWTD G N IEV+
Sbjct: 1 NDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVA 60
Query: 880 KSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMT 939
+ +GS R ++ +D+PR I V+PE G+++W++WG PCI +A +DG + L+ +
Sbjct: 61 RLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIA 120
Query: 940 WPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIENLPH--PFGLDLYGDEVFWTD 997
WPNG+++D N++YW D IE +L+ G +++ + + F + ++G ++W+D
Sbjct: 121 WPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSD 180
Query: 998 --WDTQSIQAANK----DTGAKRRTLG-------------------CGKNNGGCSHLCLL 1032
S++ +K +T R LG C ++NGGC LCL
Sbjct: 181 RAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLY 240
Query: 1033 KPGG-RSCACPIGIKLNKDGKTCADGPINYLIFAHRVDIRVISL 1075
+ R+CAC G L +DG TC YL+++ R ++ I L
Sbjct: 241 RGNSRRTCACAHGY-LAEDGVTCLRHE-GYLLYSGRTILKSIHL 282
Score = 157 bits (380), Expect = 4e-37
Identities = 79/205 (38%), Positives = 119/205 (58%), Gaps = 3/205 (1%)
Query: 559 VFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLD 618
++W++ I A+ + D+I GL G+AVDWI ++WTD G +EVA L+
Sbjct: 4 IYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLN 63
Query: 619 GSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPN 678
GS R V+++ LD+PR+IAVHP L+FWT+WG P I +A +DG ++ ++ I WPN
Sbjct: 64 GSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWPN 123
Query: 679 GLTIDYTESKIYWADAKHHVIERAAFD-GRDRRKVTTKGLPHPFALTLFDDAIYWTD-WH 736
G++IDY E+K+YW DA+ IER + G +R V + F++ +F IYW+D H
Sbjct: 124 GISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSDRAH 183
Query: 737 TK-SISTVNKNTGMGIQTVHAGLNV 760
S+ +KN T+ GL V
Sbjct: 184 ANGSVRRGHKNDATETITMRTGLGV 208
Score = 73.7 bits (173), Expect = 5e-12
Identities = 43/167 (25%), Positives = 82/167 (49%), Gaps = 4/167 (2%)
Query: 599 HDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIER 658
+D ++WTD G ++ A D + + ++ N L + IAV ++WTD G N IE
Sbjct: 1 NDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFN-LIEV 59
Query: 659 ADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWAD-AKHHVIERAAFDGRDRRKVTTKGL 717
A ++G R +I + P + + + ++W + + I +A DG ++ + + G+
Sbjct: 60 ARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGI 119
Query: 718 --PHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGLNVPM 762
P+ ++ ++ +YW D T I ++ TG + V +G NV M
Sbjct: 120 AWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDM 166
Score = 64.9 bits (151), Expect = 2e-09
Identities = 52/187 (27%), Positives = 87/187 (46%), Gaps = 7/187 (3%)
Query: 1455 NNIYWTDNEHKVIEVARLDGSSRKVLIT-GLTEPRALALFPAKGYLYWSDWGEHPYIERS 1513
+ IYWTD I A+ D + ++ +IT GL +A+ G +YW+D G + IE +
Sbjct: 2 DTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFN-LIEVA 60
Query: 1514 YLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTD-ALKDRIDTSDLNGQHRVQLVPDA-- 1570
L+GS R +I+ L P + + ++ L+WT+ I + L+G +V LV
Sbjct: 61 RLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIA 120
Query: 1571 -KNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNLEMAMEIKAVSADRQHGWN 1629
N + ++ +YW D I R D TG N ++ + + M AV + W+
Sbjct: 121 WPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYIY-WS 179
Query: 1630 PCKESNG 1636
+NG
Sbjct: 180 DRAHANG 186
Score = 55.2 bits (127), Expect = 2e-06
Identities = 42/160 (26%), Positives = 81/160 (50%), Gaps = 17/160 (10%)
Query: 537 YMSVVKGLHNAVALDYHYEKKLVFWSE-NNLRVIRVAQMNTKNMSDVIRWGLETPAGVAV 595
Y+ + +GL ++ H EK L+FW+E + I A+++ ++ G+ P G+++
Sbjct: 68 YVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWPNGISI 127
Query: 596 DWIHDLLFWTDSGTRRVEVATLD--GSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPN 653
D+ + L+W D+ T ++E L+ G++ VL +++D ++AV A ++W+D
Sbjct: 128 DYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDM-FSVAVF--GAYIYWSD---- 180
Query: 654 PKIERADMDGDKR---KTVIYDEIFWPNGLTIDYTESKIY 690
RA +G R K + I GL ++ E KI+
Sbjct: 181 ----RAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIF 216
Score = 49.2 bits (112), Expect = 1e-04
Identities = 28/101 (27%), Positives = 49/101 (48%), Gaps = 2/101 (1%)
Query: 1096 VDVDHSTGLIYWTDTGQRKIQRATRL-GTHVETVIGNGLHTADGIVIDSTGRKIYWTDGG 1154
+ V GL++WT+ GQ RL G+ ++ G+ +GI ID K+YW D
Sbjct: 81 IAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDAR 140
Query: 1155 RNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSD 1195
+ IE +L+ + +V +G + ++ Y++WSD
Sbjct: 141 TDKIERIDLETGGNREMVLSG-SNVDMFSVAVFGAYIYWSD 180
Score = 47.2 bits (107), Expect = 5e-04
Identities = 50/187 (26%), Positives = 71/187 (37%), Gaps = 15/187 (8%)
Query: 689 IYWADAKHHVIERAAFDGRDRRKVTTKGLPHP--FALTLFDDAIYWTDWHTKSISTVNKN 746
IYW D + I RA D + + T GL A+ IYWTD I N
Sbjct: 4 IYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLN 63
Query: 747 TGMGIQTVHAGLNVPMDIHSRSCEETPEKLLLYARRKDLRLKQLESKKPIDSLDMVIPVE 806
+ GL+ P RS PEK LL+ + K +D + V+ V
Sbjct: 64 GSFRYVIISQGLDQP-----RSIAVHPEKGLLF--WTEWGQMPCIGKARLDGSEKVVLVS 116
Query: 807 T-IKSAVALDWDQKSNSIFWTDVEKDTINRAYL--NGSHQTTIVDSNLIWPAGLAFDWIT 863
I + D + N ++W D D I R L G+ + + SN+ + F
Sbjct: 117 MGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVFG--- 173
Query: 864 DKIYWTD 870
IYW+D
Sbjct: 174 AYIYWSD 180
>M27445-1|AAA57261.1| 581|Homo sapiens nidogen protein.
Length = 581
Score = 184 bits (448), Expect = 3e-45
Identities = 104/303 (34%), Positives = 155/303 (51%), Gaps = 7/303 (2%)
Query: 1366 PEEFLIFATRGSITYISLESPEQWDVTLPV-KEVKNTIAVDYHWDL--KMIFYTDLDLNV 1422
P L+FA G I + LE V + + +D KM+++TD+
Sbjct: 276 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS 335
Query: 1423 IRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLI- 1481
I ++ E TII Q L +P G+ VD + NI+WTD+ IEVA+LDG+ R+VL
Sbjct: 336 IGRASLHG-GEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFE 394
Query: 1482 TGLTEPRALALFPAKGYLYWSDWG-EHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKE 1540
T L PR + +G LYW+DW ++P IE SY+DG+ R+I+VQ DLG PNGLT D
Sbjct: 395 TDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFS 454
Query: 1541 RRLYWTDALKDRIDTSDLNGQHRVQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRT 1600
+L W DA +R + + + R + + + PF +T + +Y+TDW S++ D
Sbjct: 455 SQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAI 514
Query: 1601 GKNITLIRTNLEMAM-EIKAVSADRQHGWNPCKESNGGCSHLCLFRGHEYICACPDDPDH 1659
K + + + + I + G N C +NGGC+HLCL C CPD+
Sbjct: 515 SKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLG 574
Query: 1660 VEC 1662
V+C
Sbjct: 575 VDC 577
Score = 179 bits (435), Expect = 1e-43
Identities = 93/260 (35%), Positives = 137/260 (52%), Gaps = 3/260 (1%)
Query: 1089 PLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKI 1148
P K +G+ D ++YWTD + I RA+ G T+I L + +GI +D GR I
Sbjct: 310 PAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNI 369
Query: 1149 YWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWG-TSAKIERADM 1207
+WTD + IEVA+LDG R+VL T L +PR I G ++W+DW + KIE + M
Sbjct: 370 FWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYM 429
Query: 1208 DGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLSNVPYPYG 1267
DG NRR++V + + PNGL D +L W DA E + RR L + YP+
Sbjct: 430 DGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFA 489
Query: 1268 IVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLE-GLMDIRAIQSERVL-ENACGTD 1325
+ G+++Y+TDWK ++ D + + + + + L I S+ N C +
Sbjct: 490 VTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVN 549
Query: 1326 NGGCSHLCLRSPLGYTCACP 1345
NGGC+HLCL +P TC CP
Sbjct: 550 NGGCTHLCLATPGSRTCRCP 569
Score = 174 bits (424), Expect = 2e-42
Identities = 94/258 (36%), Positives = 135/258 (52%), Gaps = 24/258 (9%)
Query: 809 KSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYW 868
K + L +D ++WTD+ + +I RA L+G TTI+ +L P G+A D + I+W
Sbjct: 312 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFW 371
Query: 869 TDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGA-SPCIERADMDG 927
TD +RIEV+K DG+ R +L + PR IV + G +YW+DW +P IE + MDG
Sbjct: 372 TDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDG 431
Query: 928 GNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIENLPHPFGLD 987
NR+ L+ + PNGL D +++ W D G E N R K +E L +PF +
Sbjct: 432 TNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVT 491
Query: 988 LYGDEVFWTDWDTQSI----QAANKDTGA-----KRRTLG--------------CGKNNG 1024
YG +++TDW S+ A +K+T A + R G C NNG
Sbjct: 492 SYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNG 551
Query: 1025 GCSHLCLLKPGGRSCACP 1042
GC+HLCL PG R+C CP
Sbjct: 552 GCTHLCLATPGSRTCRCP 569
Score = 139 bits (337), Expect = 7e-32
Identities = 73/194 (37%), Positives = 108/194 (55%), Gaps = 2/194 (1%)
Query: 548 VALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDS 607
+ L + K+V+W++ I A ++ + +IR L +P G+AVD + +FWTDS
Sbjct: 315 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDS 374
Query: 608 GTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWG-PNPKIERADMDGDKR 666
R+EVA LDG++R VL DL PR I ++WTDW NPKIE + MDG R
Sbjct: 375 NLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNR 434
Query: 667 KTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLF 726
+ ++ D++ PNGLT D S++ W DA + E RRK +GL +PFA+T +
Sbjct: 435 RILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRK-ALEGLQYPFAVTSY 493
Query: 727 DDAIYWTDWHTKSI 740
+Y+TDW S+
Sbjct: 494 GKNLYFTDWKMNSV 507
Score = 49.2 bits (112), Expect = 1e-04
Identities = 29/60 (48%), Positives = 35/60 (58%), Gaps = 6/60 (10%)
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVC-SQT-CSNTVGSFRCGCMTGYILRPDERSC 510
C C +GF D +C DIDEC EQ VC S T C+N G+FRC C+ GY DE +C
Sbjct: 29 CECSIGF--RGDGRTCYDIDECS-EQPSVCGSHTICNNHPGTFRCECVEGYQF-SDEGTC 84
Score = 44.4 bits (100), Expect = 0.004
Identities = 25/61 (40%), Positives = 30/61 (49%), Gaps = 7/61 (11%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQT--CSNTVGSFRCGCMTG 500
CI T C+C GF + D +C+D+DEC Q C C NT GSF C C G
Sbjct: 111 CIYTGGSSYTCSCLPGF--SGDGQACQDVDEC---QPSRCHPDAFCYNTPGSFTCQCKPG 165
Query: 501 Y 501
Y
Sbjct: 166 Y 166
>BC045606-1|AAH45606.1| 1114|Homo sapiens NID1 protein protein.
Length = 1114
Score = 184 bits (448), Expect = 3e-45
Identities = 104/303 (34%), Positives = 155/303 (51%), Gaps = 7/303 (2%)
Query: 1366 PEEFLIFATRGSITYISLESPEQWDVTLPV-KEVKNTIAVDYHWDL--KMIFYTDLDLNV 1422
P L+FA G I + LE V + + +D KM+++TD+
Sbjct: 809 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS 868
Query: 1423 IRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLI- 1481
I ++ E TII Q L +P G+ VD + NI+WTD+ IEVA+LDG+ R+VL
Sbjct: 869 IGRASLHG-GEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFE 927
Query: 1482 TGLTEPRALALFPAKGYLYWSDWG-EHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKE 1540
T L PR + +G LYW+DW ++P IE SY+DG+ R+I+VQ DLG PNGLT D
Sbjct: 928 TDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFS 987
Query: 1541 RRLYWTDALKDRIDTSDLNGQHRVQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRT 1600
+L W DA +R + + + R + + + PF +T + +Y+TDW S++ D
Sbjct: 988 SQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAI 1047
Query: 1601 GKNITLIRTNLEMAM-EIKAVSADRQHGWNPCKESNGGCSHLCLFRGHEYICACPDDPDH 1659
K + + + + I + G N C +NGGC+HLCL C CPD+
Sbjct: 1048 SKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLG 1107
Query: 1660 VEC 1662
V+C
Sbjct: 1108 VDC 1110
Score = 179 bits (435), Expect = 1e-43
Identities = 93/260 (35%), Positives = 137/260 (52%), Gaps = 3/260 (1%)
Query: 1089 PLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKI 1148
P K +G+ D ++YWTD + I RA+ G T+I L + +GI +D GR I
Sbjct: 843 PAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNI 902
Query: 1149 YWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWG-TSAKIERADM 1207
+WTD + IEVA+LDG R+VL T L +PR I G ++W+DW + KIE + M
Sbjct: 903 FWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYM 962
Query: 1208 DGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLSNVPYPYG 1267
DG NRR++V + + PNGL D +L W DA E + RR L + YP+
Sbjct: 963 DGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFA 1022
Query: 1268 IVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLE-GLMDIRAIQSERVL-ENACGTD 1325
+ G+++Y+TDWK ++ D + + + + + L I S+ N C +
Sbjct: 1023 VTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVN 1082
Query: 1326 NGGCSHLCLRSPLGYTCACP 1345
NGGC+HLCL +P TC CP
Sbjct: 1083 NGGCTHLCLATPGSRTCRCP 1102
Score = 174 bits (424), Expect = 2e-42
Identities = 94/258 (36%), Positives = 135/258 (52%), Gaps = 24/258 (9%)
Query: 809 KSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYW 868
K + L +D ++WTD+ + +I RA L+G TTI+ +L P G+A D + I+W
Sbjct: 845 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFW 904
Query: 869 TDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGA-SPCIERADMDG 927
TD +RIEV+K DG+ R +L + PR IV + G +YW+DW +P IE + MDG
Sbjct: 905 TDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDG 964
Query: 928 GNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIENLPHPFGLD 987
NR+ L+ + PNGL D +++ W D G E N R K +E L +PF +
Sbjct: 965 TNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVT 1024
Query: 988 LYGDEVFWTDWDTQSI----QAANKDTGA-----KRRTLG--------------CGKNNG 1024
YG +++TDW S+ A +K+T A + R G C NNG
Sbjct: 1025 SYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNG 1084
Query: 1025 GCSHLCLLKPGGRSCACP 1042
GC+HLCL PG R+C CP
Sbjct: 1085 GCTHLCLATPGSRTCRCP 1102
Score = 139 bits (337), Expect = 7e-32
Identities = 73/194 (37%), Positives = 108/194 (55%), Gaps = 2/194 (1%)
Query: 548 VALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDS 607
+ L + K+V+W++ I A ++ + +IR L +P G+AVD + +FWTDS
Sbjct: 848 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDS 907
Query: 608 GTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWG-PNPKIERADMDGDKR 666
R+EVA LDG++R VL DL PR I ++WTDW NPKIE + MDG R
Sbjct: 908 NLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNR 967
Query: 667 KTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLF 726
+ ++ D++ PNGLT D S++ W DA + E RRK +GL +PFA+T +
Sbjct: 968 RILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRK-ALEGLQYPFAVTSY 1026
Query: 727 DDAIYWTDWHTKSI 740
+Y+TDW S+
Sbjct: 1027 GKNLYFTDWKMNSV 1040
>AL139161-2|CAI23422.1| 1247|Homo sapiens nidogen 1 protein.
Length = 1247
Score = 184 bits (448), Expect = 3e-45
Identities = 104/303 (34%), Positives = 155/303 (51%), Gaps = 7/303 (2%)
Query: 1366 PEEFLIFATRGSITYISLESPEQWDVTLPV-KEVKNTIAVDYHWDL--KMIFYTDLDLNV 1422
P L+FA G I + LE V + + +D KM+++TD+
Sbjct: 942 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS 1001
Query: 1423 IRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLI- 1481
I ++ E TII Q L +P G+ VD + NI+WTD+ IEVA+LDG+ R+VL
Sbjct: 1002 IGRASLHG-GEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFE 1060
Query: 1482 TGLTEPRALALFPAKGYLYWSDWG-EHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKE 1540
T L PR + +G LYW+DW ++P IE SY+DG+ R+I+VQ DLG PNGLT D
Sbjct: 1061 TDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFS 1120
Query: 1541 RRLYWTDALKDRIDTSDLNGQHRVQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRT 1600
+L W DA +R + + + R + + + PF +T + +Y+TDW S++ D
Sbjct: 1121 SQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAI 1180
Query: 1601 GKNITLIRTNLEMAM-EIKAVSADRQHGWNPCKESNGGCSHLCLFRGHEYICACPDDPDH 1659
K + + + + I + G N C +NGGC+HLCL C CPD+
Sbjct: 1181 SKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLG 1240
Query: 1660 VEC 1662
V+C
Sbjct: 1241 VDC 1243
Score = 179 bits (435), Expect = 1e-43
Identities = 93/260 (35%), Positives = 137/260 (52%), Gaps = 3/260 (1%)
Query: 1089 PLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKI 1148
P K +G+ D ++YWTD + I RA+ G T+I L + +GI +D GR I
Sbjct: 976 PAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNI 1035
Query: 1149 YWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWG-TSAKIERADM 1207
+WTD + IEVA+LDG R+VL T L +PR I G ++W+DW + KIE + M
Sbjct: 1036 FWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYM 1095
Query: 1208 DGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLSNVPYPYG 1267
DG NRR++V + + PNGL D +L W DA E + RR L + YP+
Sbjct: 1096 DGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFA 1155
Query: 1268 IVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLE-GLMDIRAIQSERVL-ENACGTD 1325
+ G+++Y+TDWK ++ D + + + + + L I S+ N C +
Sbjct: 1156 VTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVN 1215
Query: 1326 NGGCSHLCLRSPLGYTCACP 1345
NGGC+HLCL +P TC CP
Sbjct: 1216 NGGCTHLCLATPGSRTCRCP 1235
Score = 174 bits (424), Expect = 2e-42
Identities = 94/258 (36%), Positives = 135/258 (52%), Gaps = 24/258 (9%)
Query: 809 KSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYW 868
K + L +D ++WTD+ + +I RA L+G TTI+ +L P G+A D + I+W
Sbjct: 978 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFW 1037
Query: 869 TDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGA-SPCIERADMDG 927
TD +RIEV+K DG+ R +L + PR IV + G +YW+DW +P IE + MDG
Sbjct: 1038 TDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDG 1097
Query: 928 GNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIENLPHPFGLD 987
NR+ L+ + PNGL D +++ W D G E N R K +E L +PF +
Sbjct: 1098 TNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVT 1157
Query: 988 LYGDEVFWTDWDTQSI----QAANKDTGA-----KRRTLG--------------CGKNNG 1024
YG +++TDW S+ A +K+T A + R G C NNG
Sbjct: 1158 SYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNG 1217
Query: 1025 GCSHLCLLKPGGRSCACP 1042
GC+HLCL PG R+C CP
Sbjct: 1218 GCTHLCLATPGSRTCRCP 1235
Score = 139 bits (337), Expect = 7e-32
Identities = 73/194 (37%), Positives = 108/194 (55%), Gaps = 2/194 (1%)
Query: 548 VALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDS 607
+ L + K+V+W++ I A ++ + +IR L +P G+AVD + +FWTDS
Sbjct: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDS 1040
Query: 608 GTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWG-PNPKIERADMDGDKR 666
R+EVA LDG++R VL DL PR I ++WTDW NPKIE + MDG R
Sbjct: 1041 NLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNR 1100
Query: 667 KTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLF 726
+ ++ D++ PNGLT D S++ W DA + E RRK +GL +PFA+T +
Sbjct: 1101 RILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRK-ALEGLQYPFAVTSY 1159
Query: 727 DDAIYWTDWHTKSI 740
+Y+TDW S+
Sbjct: 1160 GKNLYFTDWKMNSV 1173
Score = 49.2 bits (112), Expect = 1e-04
Identities = 29/60 (48%), Positives = 35/60 (58%), Gaps = 6/60 (10%)
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVC-SQT-CSNTVGSFRCGCMTGYILRPDERSC 510
C C +GF D +C DIDEC EQ VC S T C+N G+FRC C+ GY DE +C
Sbjct: 695 CECSIGF--RGDGRTCYDIDECS-EQPSVCGSHTICNNHPGTFRCECVEGYQF-SDEGTC 750
Score = 44.4 bits (100), Expect = 0.004
Identities = 25/61 (40%), Positives = 30/61 (49%), Gaps = 7/61 (11%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQT--CSNTVGSFRCGCMTG 500
CI T C+C GF + D +C+D+DEC Q C C NT GSF C C G
Sbjct: 777 CIYTGGSSYTCSCLPGF--SGDGQACQDVDEC---QPSRCHPDAFCYNTPGSFTCQCKPG 831
Query: 501 Y 501
Y
Sbjct: 832 Y 832
>AL139161-1|CAI23421.1| 1114|Homo sapiens nidogen 1 protein.
Length = 1114
Score = 184 bits (448), Expect = 3e-45
Identities = 104/303 (34%), Positives = 155/303 (51%), Gaps = 7/303 (2%)
Query: 1366 PEEFLIFATRGSITYISLESPEQWDVTLPV-KEVKNTIAVDYHWDL--KMIFYTDLDLNV 1422
P L+FA G I + LE V + + +D KM+++TD+
Sbjct: 809 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS 868
Query: 1423 IRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLI- 1481
I ++ E TII Q L +P G+ VD + NI+WTD+ IEVA+LDG+ R+VL
Sbjct: 869 IGRASLHG-GEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFE 927
Query: 1482 TGLTEPRALALFPAKGYLYWSDWG-EHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKE 1540
T L PR + +G LYW+DW ++P IE SY+DG+ R+I+VQ DLG PNGLT D
Sbjct: 928 TDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFS 987
Query: 1541 RRLYWTDALKDRIDTSDLNGQHRVQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRT 1600
+L W DA +R + + + R + + + PF +T + +Y+TDW S++ D
Sbjct: 988 SQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAI 1047
Query: 1601 GKNITLIRTNLEMAM-EIKAVSADRQHGWNPCKESNGGCSHLCLFRGHEYICACPDDPDH 1659
K + + + + I + G N C +NGGC+HLCL C CPD+
Sbjct: 1048 SKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLG 1107
Query: 1660 VEC 1662
V+C
Sbjct: 1108 VDC 1110
Score = 179 bits (435), Expect = 1e-43
Identities = 93/260 (35%), Positives = 137/260 (52%), Gaps = 3/260 (1%)
Query: 1089 PLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKI 1148
P K +G+ D ++YWTD + I RA+ G T+I L + +GI +D GR I
Sbjct: 843 PAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNI 902
Query: 1149 YWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWG-TSAKIERADM 1207
+WTD + IEVA+LDG R+VL T L +PR I G ++W+DW + KIE + M
Sbjct: 903 FWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYM 962
Query: 1208 DGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLSNVPYPYG 1267
DG NRR++V + + PNGL D +L W DA E + RR L + YP+
Sbjct: 963 DGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFA 1022
Query: 1268 IVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLE-GLMDIRAIQSERVL-ENACGTD 1325
+ G+++Y+TDWK ++ D + + + + + L I S+ N C +
Sbjct: 1023 VTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVN 1082
Query: 1326 NGGCSHLCLRSPLGYTCACP 1345
NGGC+HLCL +P TC CP
Sbjct: 1083 NGGCTHLCLATPGSRTCRCP 1102
Score = 174 bits (424), Expect = 2e-42
Identities = 94/258 (36%), Positives = 135/258 (52%), Gaps = 24/258 (9%)
Query: 809 KSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYW 868
K + L +D ++WTD+ + +I RA L+G TTI+ +L P G+A D + I+W
Sbjct: 845 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFW 904
Query: 869 TDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGA-SPCIERADMDG 927
TD +RIEV+K DG+ R +L + PR IV + G +YW+DW +P IE + MDG
Sbjct: 905 TDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDG 964
Query: 928 GNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIENLPHPFGLD 987
NR+ L+ + PNGL D +++ W D G E N R K +E L +PF +
Sbjct: 965 TNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVT 1024
Query: 988 LYGDEVFWTDWDTQSI----QAANKDTGA-----KRRTLG--------------CGKNNG 1024
YG +++TDW S+ A +K+T A + R G C NNG
Sbjct: 1025 SYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNG 1084
Query: 1025 GCSHLCLLKPGGRSCACP 1042
GC+HLCL PG R+C CP
Sbjct: 1085 GCTHLCLATPGSRTCRCP 1102
Score = 139 bits (337), Expect = 7e-32
Identities = 73/194 (37%), Positives = 108/194 (55%), Gaps = 2/194 (1%)
Query: 548 VALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDS 607
+ L + K+V+W++ I A ++ + +IR L +P G+AVD + +FWTDS
Sbjct: 848 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDS 907
Query: 608 GTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWG-PNPKIERADMDGDKR 666
R+EVA LDG++R VL DL PR I ++WTDW NPKIE + MDG R
Sbjct: 908 NLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNR 967
Query: 667 KTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLF 726
+ ++ D++ PNGLT D S++ W DA + E RRK +GL +PFA+T +
Sbjct: 968 RILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRK-ALEGLQYPFAVTSY 1026
Query: 727 DDAIYWTDWHTKSI 740
+Y+TDW S+
Sbjct: 1027 GKNLYFTDWKMNSV 1040
>AL122018-2|CAI22681.1| 1247|Homo sapiens nidogen 1 protein.
Length = 1247
Score = 184 bits (448), Expect = 3e-45
Identities = 104/303 (34%), Positives = 155/303 (51%), Gaps = 7/303 (2%)
Query: 1366 PEEFLIFATRGSITYISLESPEQWDVTLPV-KEVKNTIAVDYHWDL--KMIFYTDLDLNV 1422
P L+FA G I + LE V + + +D KM+++TD+
Sbjct: 942 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS 1001
Query: 1423 IRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLI- 1481
I ++ E TII Q L +P G+ VD + NI+WTD+ IEVA+LDG+ R+VL
Sbjct: 1002 IGRASLHG-GEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFE 1060
Query: 1482 TGLTEPRALALFPAKGYLYWSDWG-EHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKE 1540
T L PR + +G LYW+DW ++P IE SY+DG+ R+I+VQ DLG PNGLT D
Sbjct: 1061 TDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFS 1120
Query: 1541 RRLYWTDALKDRIDTSDLNGQHRVQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRT 1600
+L W DA +R + + + R + + + PF +T + +Y+TDW S++ D
Sbjct: 1121 SQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAI 1180
Query: 1601 GKNITLIRTNLEMAM-EIKAVSADRQHGWNPCKESNGGCSHLCLFRGHEYICACPDDPDH 1659
K + + + + I + G N C +NGGC+HLCL C CPD+
Sbjct: 1181 SKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLG 1240
Query: 1660 VEC 1662
V+C
Sbjct: 1241 VDC 1243
Score = 179 bits (435), Expect = 1e-43
Identities = 93/260 (35%), Positives = 137/260 (52%), Gaps = 3/260 (1%)
Query: 1089 PLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKI 1148
P K +G+ D ++YWTD + I RA+ G T+I L + +GI +D GR I
Sbjct: 976 PAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNI 1035
Query: 1149 YWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWG-TSAKIERADM 1207
+WTD + IEVA+LDG R+VL T L +PR I G ++W+DW + KIE + M
Sbjct: 1036 FWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYM 1095
Query: 1208 DGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLSNVPYPYG 1267
DG NRR++V + + PNGL D +L W DA E + RR L + YP+
Sbjct: 1096 DGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFA 1155
Query: 1268 IVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLE-GLMDIRAIQSERVL-ENACGTD 1325
+ G+++Y+TDWK ++ D + + + + + L I S+ N C +
Sbjct: 1156 VTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVN 1215
Query: 1326 NGGCSHLCLRSPLGYTCACP 1345
NGGC+HLCL +P TC CP
Sbjct: 1216 NGGCTHLCLATPGSRTCRCP 1235
Score = 174 bits (424), Expect = 2e-42
Identities = 94/258 (36%), Positives = 135/258 (52%), Gaps = 24/258 (9%)
Query: 809 KSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYW 868
K + L +D ++WTD+ + +I RA L+G TTI+ +L P G+A D + I+W
Sbjct: 978 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFW 1037
Query: 869 TDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGA-SPCIERADMDG 927
TD +RIEV+K DG+ R +L + PR IV + G +YW+DW +P IE + MDG
Sbjct: 1038 TDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDG 1097
Query: 928 GNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIENLPHPFGLD 987
NR+ L+ + PNGL D +++ W D G E N R K +E L +PF +
Sbjct: 1098 TNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVT 1157
Query: 988 LYGDEVFWTDWDTQSI----QAANKDTGA-----KRRTLG--------------CGKNNG 1024
YG +++TDW S+ A +K+T A + R G C NNG
Sbjct: 1158 SYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNG 1217
Query: 1025 GCSHLCLLKPGGRSCACP 1042
GC+HLCL PG R+C CP
Sbjct: 1218 GCTHLCLATPGSRTCRCP 1235
Score = 139 bits (337), Expect = 7e-32
Identities = 73/194 (37%), Positives = 108/194 (55%), Gaps = 2/194 (1%)
Query: 548 VALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDS 607
+ L + K+V+W++ I A ++ + +IR L +P G+AVD + +FWTDS
Sbjct: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDS 1040
Query: 608 GTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWG-PNPKIERADMDGDKR 666
R+EVA LDG++R VL DL PR I ++WTDW NPKIE + MDG R
Sbjct: 1041 NLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNR 1100
Query: 667 KTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLF 726
+ ++ D++ PNGLT D S++ W DA + E RRK +GL +PFA+T +
Sbjct: 1101 RILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRK-ALEGLQYPFAVTSY 1159
Query: 727 DDAIYWTDWHTKSI 740
+Y+TDW S+
Sbjct: 1160 GKNLYFTDWKMNSV 1173
Score = 49.2 bits (112), Expect = 1e-04
Identities = 29/60 (48%), Positives = 35/60 (58%), Gaps = 6/60 (10%)
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVC-SQT-CSNTVGSFRCGCMTGYILRPDERSC 510
C C +GF D +C DIDEC EQ VC S T C+N G+FRC C+ GY DE +C
Sbjct: 695 CECSIGF--RGDGRTCYDIDECS-EQPSVCGSHTICNNHPGTFRCECVEGYQF-SDEGTC 750
Score = 44.4 bits (100), Expect = 0.004
Identities = 25/61 (40%), Positives = 30/61 (49%), Gaps = 7/61 (11%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQT--CSNTVGSFRCGCMTG 500
CI T C+C GF + D +C+D+DEC Q C C NT GSF C C G
Sbjct: 777 CIYTGGSSYTCSCLPGF--SGDGQACQDVDEC---QPSRCHPDAFCYNTPGSFTCQCKPG 831
Query: 501 Y 501
Y
Sbjct: 832 Y 832
>AL122018-1|CAI22680.1| 1114|Homo sapiens nidogen 1 protein.
Length = 1114
Score = 184 bits (448), Expect = 3e-45
Identities = 104/303 (34%), Positives = 155/303 (51%), Gaps = 7/303 (2%)
Query: 1366 PEEFLIFATRGSITYISLESPEQWDVTLPV-KEVKNTIAVDYHWDL--KMIFYTDLDLNV 1422
P L+FA G I + LE V + + +D KM+++TD+
Sbjct: 809 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS 868
Query: 1423 IRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLI- 1481
I ++ E TII Q L +P G+ VD + NI+WTD+ IEVA+LDG+ R+VL
Sbjct: 869 IGRASLHG-GEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFE 927
Query: 1482 TGLTEPRALALFPAKGYLYWSDWG-EHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKE 1540
T L PR + +G LYW+DW ++P IE SY+DG+ R+I+VQ DLG PNGLT D
Sbjct: 928 TDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFS 987
Query: 1541 RRLYWTDALKDRIDTSDLNGQHRVQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRT 1600
+L W DA +R + + + R + + + PF +T + +Y+TDW S++ D
Sbjct: 988 SQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAI 1047
Query: 1601 GKNITLIRTNLEMAM-EIKAVSADRQHGWNPCKESNGGCSHLCLFRGHEYICACPDDPDH 1659
K + + + + I + G N C +NGGC+HLCL C CPD+
Sbjct: 1048 SKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLG 1107
Query: 1660 VEC 1662
V+C
Sbjct: 1108 VDC 1110
Score = 179 bits (435), Expect = 1e-43
Identities = 93/260 (35%), Positives = 137/260 (52%), Gaps = 3/260 (1%)
Query: 1089 PLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKI 1148
P K +G+ D ++YWTD + I RA+ G T+I L + +GI +D GR I
Sbjct: 843 PAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNI 902
Query: 1149 YWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWG-TSAKIERADM 1207
+WTD + IEVA+LDG R+VL T L +PR I G ++W+DW + KIE + M
Sbjct: 903 FWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYM 962
Query: 1208 DGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLSNVPYPYG 1267
DG NRR++V + + PNGL D +L W DA E + RR L + YP+
Sbjct: 963 DGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFA 1022
Query: 1268 IVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLE-GLMDIRAIQSERVL-ENACGTD 1325
+ G+++Y+TDWK ++ D + + + + + L I S+ N C +
Sbjct: 1023 VTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVN 1082
Query: 1326 NGGCSHLCLRSPLGYTCACP 1345
NGGC+HLCL +P TC CP
Sbjct: 1083 NGGCTHLCLATPGSRTCRCP 1102
Score = 174 bits (424), Expect = 2e-42
Identities = 94/258 (36%), Positives = 135/258 (52%), Gaps = 24/258 (9%)
Query: 809 KSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYW 868
K + L +D ++WTD+ + +I RA L+G TTI+ +L P G+A D + I+W
Sbjct: 845 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFW 904
Query: 869 TDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGA-SPCIERADMDG 927
TD +RIEV+K DG+ R +L + PR IV + G +YW+DW +P IE + MDG
Sbjct: 905 TDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDG 964
Query: 928 GNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIENLPHPFGLD 987
NR+ L+ + PNGL D +++ W D G E N R K +E L +PF +
Sbjct: 965 TNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVT 1024
Query: 988 LYGDEVFWTDWDTQSI----QAANKDTGA-----KRRTLG--------------CGKNNG 1024
YG +++TDW S+ A +K+T A + R G C NNG
Sbjct: 1025 SYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNG 1084
Query: 1025 GCSHLCLLKPGGRSCACP 1042
GC+HLCL PG R+C CP
Sbjct: 1085 GCTHLCLATPGSRTCRCP 1102
Score = 139 bits (337), Expect = 7e-32
Identities = 73/194 (37%), Positives = 108/194 (55%), Gaps = 2/194 (1%)
Query: 548 VALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDS 607
+ L + K+V+W++ I A ++ + +IR L +P G+AVD + +FWTDS
Sbjct: 848 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDS 907
Query: 608 GTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWG-PNPKIERADMDGDKR 666
R+EVA LDG++R VL DL PR I ++WTDW NPKIE + MDG R
Sbjct: 908 NLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNR 967
Query: 667 KTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLF 726
+ ++ D++ PNGLT D S++ W DA + E RRK +GL +PFA+T +
Sbjct: 968 RILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRK-ALEGLQYPFAVTSY 1026
Query: 727 DDAIYWTDWHTKSI 740
+Y+TDW S+
Sbjct: 1027 GKNLYFTDWKMNSV 1040
>Y08110-1|CAA69325.1| 2214|Homo sapiens mosaic protein LR11 protein.
Length = 2214
Score = 181 bits (441), Expect = 2e-44
Identities = 109/313 (34%), Positives = 165/313 (52%), Gaps = 33/313 (10%)
Query: 775 KLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTIN 834
+ +LYA RK + L S +P+ +++AVALD+D + N ++W+D+ D I
Sbjct: 759 EFILYAVRKSIYRYDLAS-----GATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQ 813
Query: 835 RAYLNGSH-QTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMR-TLLAWD 892
R LNGS Q I++S L LAF+ ++ +YW D G +IEV+ DG R T++
Sbjct: 814 RLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSS 873
Query: 893 HIDKPRDIVVNPEGGVMYWSDWG-ASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHN 951
+D+PR +V+ P+ GVM+W+DWG P I R++MDG L+ + WPNG+++D
Sbjct: 874 VLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD--DQ 931
Query: 952 RIYWTDGGNKTIEYANLDGTGRTKLIENLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTG 1011
IYWTD + IE G R+ +++NLPHP+ + ++ +E++W DW SI A+K +G
Sbjct: 932 WIYWTDAYLECIERITFSGQQRSVILDNLPHPYAIAVFKNEIYWDDWSQLSIFRASKYSG 991
Query: 1012 AKRRTLG-------------CGKNNGG-------CSHLCLLKP-GGRSCACP--IGIKLN 1048
++ L GKN G CS LCL K RSC CP + +
Sbjct: 992 SQMEILANQLTGLMDMKIFYKGKNTGSNACVPRPCSLLCLPKANNSRSCRCPEDVSSSVL 1051
Query: 1049 KDGKTCADGPINY 1061
G D P Y
Sbjct: 1052 PSGDLMCDCPQGY 1064
Score = 180 bits (439), Expect = 3e-44
Identities = 97/266 (36%), Positives = 142/266 (53%), Gaps = 9/266 (3%)
Query: 1085 LPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLG-THVETVIGNGLHTADGIVIDS 1143
LPL L+ A+ +D D+ +YW+D IQR G T E +I +GL T + + +
Sbjct: 782 LPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEP 841
Query: 1144 TGRKIYWTDGGRNSIEVAELDGRNRKVLVWTG-LDSPRAIALHYEYGYMFWSDWGT-SAK 1201
+ +YW D G IEVA DG R +V + LD PRA+ L + G MFW+DWG
Sbjct: 842 LSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPG 901
Query: 1202 IERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLSN 1261
I R++MDG+ +V +KWPNG+++D + +YW DA + IE F G R +L N
Sbjct: 902 IYRSNMDGSAAYHLVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQQRSVILDN 959
Query: 1262 VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAI-QSERVLEN 1320
+P+PY I + IYW DW ++ RA K + S ++ L GLMD++ + + N
Sbjct: 960 LPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGSN 1019
Query: 1321 ACGTDNGGCSHLCL-RSPLGYTCACP 1345
AC CS LCL ++ +C CP
Sbjct: 1020 ACVP--RPCSLLCLPKANNSRSCRCP 1043
Score = 178 bits (433), Expect = 2e-43
Identities = 97/293 (33%), Positives = 161/293 (54%), Gaps = 10/293 (3%)
Query: 1368 EFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSIN 1427
EF+++A R SI L S LP+ ++ +A+D+ ++ ++++DL L+VI+ +
Sbjct: 759 EFILYAVRKSIYRYDLASGATEQ--LPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLC 816
Query: 1428 MTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITG--LT 1485
+ + + II+ LET L + ++ +YW D K IEVA DG R ++ L
Sbjct: 817 LNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLD 876
Query: 1486 EPRALALFPAKGYLYWSDWGE-HPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLY 1544
PRAL L P +G ++W+DWG+ P I RS +DGS +V D+ +PNG+++D ++ +Y
Sbjct: 877 RPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD--DQWIY 934
Query: 1545 WTDALKDRIDTSDLNGQHRVQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNI 1604
WTDA + I+ +GQ R ++ + +P+ + FK+ IYW DW + SI RA K +G +
Sbjct: 935 WTDAYLECIERITFSGQQRSVILDNLPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQM 994
Query: 1605 TLIRTNLEMAMEIKAVSADRQHGWNPCKESNGGCSHLCLFR-GHEYICACPDD 1656
++ L M++K + G N C CS LCL + + C CP+D
Sbjct: 995 EILANQLTGLMDMKIFYKGKNTGSNACVPR--PCSLLCLPKANNSRSCRCPED 1045
Score = 171 bits (415), Expect = 3e-41
Identities = 94/259 (36%), Positives = 147/259 (56%), Gaps = 7/259 (2%)
Query: 510 CKPTGESPTLLFSNRIGIRQVWL-TGDNYMSVVKGLHNAVALDYHYEKKLVFWSENNLRV 568
C E+ +L++ R I + L +G + GL AVALD+ YE ++WS+ L V
Sbjct: 752 CPLAEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDV 811
Query: 569 IRVAQMNTKNMSDVI-RWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVA 627
I+ +N +VI GLET +A + + LL+W D+G +++EVA DG R +V
Sbjct: 812 IQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVN 871
Query: 628 ND-LDKPRAIAVHPGDALVFWTDWGP-NPKIERADMDGDKRKTVIYDEIFWPNGLTIDYT 685
+ LD+PRA+ + P + ++FWTDWG P I R++MDG ++ +++ WPNG+++D
Sbjct: 872 SSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD-- 929
Query: 686 ESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNK 745
+ IYW DA IER F G+ +R V LPHP+A+ +F + IYW DW SI +K
Sbjct: 930 DQWIYWTDAYLECIERITFSGQ-QRSVILDNLPHPYAIAVFKNEIYWDDWSQLSIFRASK 988
Query: 746 NTGMGIQTVHAGLNVPMDI 764
+G ++ + L MD+
Sbjct: 989 YSGSQMEILANQLTGLMDM 1007
Score = 155 bits (375), Expect = 2e-36
Identities = 103/354 (29%), Positives = 158/354 (44%), Gaps = 52/354 (14%)
Query: 163 NRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTV 222
N+ C + N CI W CD DNDCGD SDE N I D+ T
Sbjct: 1081 NQYRCSNGN-CINSIWWCDFDNDCGDMSDE--------------RNCPTTICDLDTQFRC 1125
Query: 223 LIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQC 282
+ T + + Y+ DN+ E+ +C ++ C + C+ + C
Sbjct: 1126 QESGT--CIPLSYKCDLEDDCGDNSDESHC------EMHQCRSDEYNCSSGMCIRSSWVC 1177
Query: 283 DGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDE--LNCKP 340
DGDNDC DW+DE +C + +C A F+C +G CIP+RW CD + DC DG DE +NC+
Sbjct: 1178 DGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCE- 1236
Query: 341 NSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEE-DQYTCRPQEHLMS 399
+ C + + C + C+ + CDG+RDC++G DE +CE C + C+ ++
Sbjct: 1237 ---KKC--NGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQ---- 1287
Query: 400 NAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGF 459
C+ VCDG+ C G DE+ CS + + K+C C G
Sbjct: 1288 ----QCLFHSMVCDGIIQCRDGSDEDAA--FAGCSQDPEFHKVC-----DEFGFQCQNGV 1336
Query: 460 LLAEDKYSCRDIDEC-MYEQDPVCSQ--TCSNTVGSFRCGCMTGYILRPDERSC 510
++ + C +D+C Y + C N F+ C G+ + P+ C
Sbjct: 1337 CISL-IWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCI-PNRWKC 1388
Score = 142 bits (343), Expect = 1e-32
Identities = 102/353 (28%), Positives = 153/353 (43%), Gaps = 41/353 (11%)
Query: 111 DDAGCIT---PCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTIC 167
D+A C C NF C+ + CIP +R +C++ N C
Sbjct: 1188 DEANCTAIYHTCEASNFQCR-NGHCIP--QRWACDGDTDCQDGSDEDPVNCEKKCNGFRC 1244
Query: 168 HSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALT 227
+ CI CDG DC D SDE +C+ + T + N + + V +
Sbjct: 1245 PN-GTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFM---DFVCKNRQQCLFHSMVCDGII 1300
Query: 228 KPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDND 287
+ C + ++AA + + + C E F+C+N C+ ++CDG +D
Sbjct: 1301 Q----------CRDGSDEDAAFAGCSQDPEFHKV-CDEFGFQCQNGVCISLIWKCDGMDD 1349
Query: 288 CGDWTDEDSC--PMVPGSCNAG-EFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSI- 343
CGD++DE +C P +C+ +F+C +G CIP RW+CD E DC D DE +C + I
Sbjct: 1350 CGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHIL 1409
Query: 344 -------RNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ-- 394
C + Y C+ CV+ TW+CDG RDC +G DE C + + Q
Sbjct: 1410 PFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLG 1469
Query: 395 ----EHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKR--KC-SAEEKCE 440
+ + C+ CDG +DC G DE CP C S E +CE
Sbjct: 1470 RCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCE 1522
Score = 136 bits (330), Expect = 5e-31
Identities = 65/186 (34%), Positives = 94/186 (50%), Gaps = 17/186 (9%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND-GKCIPERW 321
C + C N C+ + CD DNDCGD +DE +CP + +F+C + G CIP +
Sbjct: 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDT-QFRCQESGTCIPLSY 1136
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCE 381
+CD E DC D DE +C+ + C DEY C+ C+ +W+CDG DC + DE NC
Sbjct: 1137 KCDLEDDCGDNSDESHCE---MHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCT 1193
Query: 382 V---SCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEK 438
+CE + CR N +C+ ++ CDG DC G DE+ ++KC+
Sbjct: 1194 AIYHTCEASNFQCR-------NG--HCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRC 1244
Query: 439 CEKLCI 444
CI
Sbjct: 1245 PNGTCI 1250
Score = 125 bits (302), Expect = 1e-27
Identities = 64/192 (33%), Positives = 87/192 (45%), Gaps = 25/192 (13%)
Query: 257 PVELMRCAE-IDFECKNTKCVPKDFQCDGDNDCGDWTDEDSC------PMV---PGSCNA 306
P E C+ F C+N C+P ++CD +NDCGDW+DE C P P +C
Sbjct: 1362 PTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLP 1421
Query: 307 GEFKCNDGKCIPERWRCDNERDCADGGDELNCK----------PNSIRNCSLDEYTCADR 356
++C+ G C+ + W CD RDCADG DE C P + C E+ C
Sbjct: 1422 NYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQP 1481
Query: 357 RCVLKTWL-CDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGM 415
+ + W CDG +DC +G DE NC TC +E + C+ CDG
Sbjct: 1482 KTCIPNWKRCDGHQDCQDGRDEANCPT---HSTLTCMSREFQCEDG-EACIVLSERCDGF 1537
Query: 416 KDCPRGDDEERC 427
DC DE+ C
Sbjct: 1538 LDCSDESDEKAC 1549
Score = 90.2 bits (214), Expect = 6e-17
Identities = 65/220 (29%), Positives = 93/220 (42%), Gaps = 33/220 (15%)
Query: 279 DFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNC 338
D CD G ++C +C +++C++G CI W CD + DC D DE NC
Sbjct: 1055 DLMCDCPQ--GYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC 1112
Query: 339 KPNSIRNCSLD-EYTCADR-RCVLKTWLCDGVRDCTNGEDEMNCEV-SCEEDQYTCRPQE 395
P +I C LD ++ C + C+ ++ CD DC + DE +CE+ C D+Y C
Sbjct: 1113 -PTTI--CDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNC---- 1165
Query: 396 HLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACAC 455
S+ C+ VCDG DC DE C + CE +GH
Sbjct: 1166 ---SSGM--CIRSSWVCDGDNDCRDWSDEANC-----TAIYHTCEASNFQCRNGH---CI 1212
Query: 456 PMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRC 495
P + D C+D ++DPV C FRC
Sbjct: 1213 PQRWACDGDT-DCQDGS----DEDPV---NCEKKCNGFRC 1244
Score = 62.1 bits (144), Expect = 2e-08
Identities = 40/131 (30%), Positives = 70/131 (53%), Gaps = 6/131 (4%)
Query: 1155 RNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGN-NRR 1213
R SI +L + L TGL + A+ YE+ ++WSD I+R ++G+ +
Sbjct: 766 RKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDV-IQRLCLNGSTGQE 824
Query: 1214 VIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLSN--VPYPYGIVIV 1271
VI+++ ++ LA + + LYW DA IE ++ DG R T++++ + P +V+V
Sbjct: 825 VIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLV 884
Query: 1272 GQH--IYWTDW 1280
Q ++WTDW
Sbjct: 885 PQEGVMFWTDW 895
Score = 58.0 bits (134), Expect = 3e-07
Identities = 33/92 (35%), Positives = 45/92 (48%), Gaps = 8/92 (8%)
Query: 111 DDAGCITP-C-LKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTICH 168
D+ C T C L F CQ S TCIP+ + C+ H+ R+ +
Sbjct: 1108 DERNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESH----CEMHQCRSDEY 1163
Query: 169 --STNVCIALEWLCDGDNDCGDFSDEINCDVV 198
S+ +CI W+CDGDNDC D+SDE NC +
Sbjct: 1164 NCSSGMCIRSSWVCDGDNDCRDWSDEANCTAI 1195
Score = 36.7 bits (81), Expect = 0.76
Identities = 26/83 (31%), Positives = 28/83 (33%), Gaps = 10/83 (12%)
Query: 119 CLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTI------CHSTNV 172
C + F C TCIP KR +C H T C
Sbjct: 1471 CDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEA----NCPTHSTLTCMSREFQCEDGEA 1526
Query: 173 CIALEWLCDGDNDCGDFSDEINC 195
CI L CDG DC D SDE C
Sbjct: 1527 CIVLSERCDGFLDCSDESDEKAC 1549
>X82245-1|CAA57709.1| 1246|Homo sapiens nidogen protein.
Length = 1246
Score = 181 bits (441), Expect = 2e-44
Identities = 103/303 (33%), Positives = 154/303 (50%), Gaps = 7/303 (2%)
Query: 1366 PEEFLIFATRGSITYISLESPEQWDVTLPV-KEVKNTIAVDYHWDL--KMIFYTDLDLNV 1422
P L+FA G I + LE V + + +D KM+++TD+
Sbjct: 941 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS 1000
Query: 1423 IRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLI- 1481
I ++ E TII Q L +P G+ VD + NI+WTD+ IEVA+LDG+ R+VL
Sbjct: 1001 IGRASLHG-GEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFE 1059
Query: 1482 TGLTEPRALALFPAKGYLYWSDWG-EHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKE 1540
T L PR + +G LYW+DW ++P IE SY+DG+ R+I+VQ DLG PNGL D
Sbjct: 1060 TDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFS 1119
Query: 1541 RRLYWTDALKDRIDTSDLNGQHRVQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRT 1600
+L W DA +R + + + R + + + PF +T + +Y+TDW S++ D
Sbjct: 1120 SQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAI 1179
Query: 1601 GKNITLIRTNLEMAM-EIKAVSADRQHGWNPCKESNGGCSHLCLFRGHEYICACPDDPDH 1659
K + + + + I + G N C +NGGC+HLCL C CPD+
Sbjct: 1180 SKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLG 1239
Query: 1660 VEC 1662
V+C
Sbjct: 1240 VDC 1242
Score = 178 bits (433), Expect = 2e-43
Identities = 93/260 (35%), Positives = 137/260 (52%), Gaps = 3/260 (1%)
Query: 1089 PLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKI 1148
P K +G+ D ++YWTD + I RA+ G T+I L + +GI +D GR I
Sbjct: 975 PAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNI 1034
Query: 1149 YWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWG-TSAKIERADM 1207
+WTD + IEVA+LDG R+VL T L +PR I G ++W+DW + KIE + M
Sbjct: 1035 FWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYM 1094
Query: 1208 DGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLSNVPYPYG 1267
DG NRR++V + + PNGL D +L W DA E + RR L + YP+
Sbjct: 1095 DGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFA 1154
Query: 1268 IVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLE-GLMDIRAIQSERVL-ENACGTD 1325
+ G+++Y+TDWK ++ D + + + + + L I S+ N C +
Sbjct: 1155 VTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVN 1214
Query: 1326 NGGCSHLCLRSPLGYTCACP 1345
NGGC+HLCL +P TC CP
Sbjct: 1215 NGGCTHLCLATPGSRTCRCP 1234
Score = 173 bits (422), Expect = 4e-42
Identities = 94/258 (36%), Positives = 135/258 (52%), Gaps = 24/258 (9%)
Query: 809 KSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYW 868
K + L +D ++WTD+ + +I RA L+G TTI+ +L P G+A D + I+W
Sbjct: 977 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFW 1036
Query: 869 TDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGA-SPCIERADMDG 927
TD +RIEV+K DG+ R +L + PR IV + G +YW+DW +P IE + MDG
Sbjct: 1037 TDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDG 1096
Query: 928 GNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIENLPHPFGLD 987
NR+ L+ + PNGL D +++ W D G E N R K +E L +PF +
Sbjct: 1097 TNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVT 1156
Query: 988 LYGDEVFWTDWDTQSI----QAANKDTGA-----KRRTLG--------------CGKNNG 1024
YG +++TDW S+ A +K+T A + R G C NNG
Sbjct: 1157 SYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNG 1216
Query: 1025 GCSHLCLLKPGGRSCACP 1042
GC+HLCL PG R+C CP
Sbjct: 1217 GCTHLCLATPGSRTCRCP 1234
Score = 136 bits (330), Expect = 5e-31
Identities = 72/194 (37%), Positives = 107/194 (55%), Gaps = 2/194 (1%)
Query: 548 VALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDS 607
+ L + K+V+W++ I A ++ + +IR L +P G+AVD + +FWTDS
Sbjct: 980 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDS 1039
Query: 608 GTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWG-PNPKIERADMDGDKR 666
R+EVA LDG++R VL DL PR I ++WTDW NPKIE + MDG R
Sbjct: 1040 NLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNR 1099
Query: 667 KTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLF 726
+ ++ D++ PNGL D S++ W DA + E RRK +GL +PFA+T +
Sbjct: 1100 RILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRK-ALEGLQYPFAVTSY 1158
Query: 727 DDAIYWTDWHTKSI 740
+Y+TDW S+
Sbjct: 1159 GKNLYFTDWKMNSV 1172
Score = 49.2 bits (112), Expect = 1e-04
Identities = 29/60 (48%), Positives = 35/60 (58%), Gaps = 6/60 (10%)
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVC-SQT-CSNTVGSFRCGCMTGYILRPDERSC 510
C C +GF D +C DIDEC EQ VC S T C+N G+FRC C+ GY DE +C
Sbjct: 694 CECSIGF--RGDGRTCYDIDECS-EQPSVCGSHTICNNHPGTFRCECVEGYQF-SDEGTC 749
Score = 44.4 bits (100), Expect = 0.004
Identities = 25/61 (40%), Positives = 30/61 (49%), Gaps = 7/61 (11%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQT--CSNTVGSFRCGCMTG 500
CI T C+C GF + D +C+D+DEC Q C C NT GSF C C G
Sbjct: 776 CIYTGGSSYTCSCLPGF--SGDGQACQDVDEC---QPSRCHPDAFCYNTPGSFTCQCKPG 830
Query: 501 Y 501
Y
Sbjct: 831 Y 831
>U60975-1|AAC50891.2| 2214|Homo sapiens gp250 precursor protein.
Length = 2214
Score = 181 bits (441), Expect = 2e-44
Identities = 109/313 (34%), Positives = 165/313 (52%), Gaps = 33/313 (10%)
Query: 775 KLLLYARRKDLRLKQLESKKPIDSLDMVIPVETIKSAVALDWDQKSNSIFWTDVEKDTIN 834
+ +LYA RK + L S +P+ +++AVALD+D + N ++W+D+ D I
Sbjct: 759 EFILYAVRKSIYRYDLAS-----GATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQ 813
Query: 835 RAYLNGSH-QTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMR-TLLAWD 892
R LNGS Q I++S L LAF+ ++ +YW D G +IEV+ DG R T++
Sbjct: 814 RLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSS 873
Query: 893 HIDKPRDIVVNPEGGVMYWSDWG-ASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHN 951
+D+PR +V+ P+ GVM+W+DWG P I R++MDG L+ + WPNG+++D
Sbjct: 874 VLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD--DQ 931
Query: 952 RIYWTDGGNKTIEYANLDGTGRTKLIENLPHPFGLDLYGDEVFWTDWDTQSIQAANKDTG 1011
IYWTD + IE G R+ +++NLPHP+ + ++ +E++W DW SI A+K +G
Sbjct: 932 WIYWTDAYLECIERITFSGQQRSVILDNLPHPYAIAVFKNEIYWDDWSQLSIFRASKYSG 991
Query: 1012 AKRRTLG-------------CGKNNGG-------CSHLCLLKP-GGRSCACP--IGIKLN 1048
++ L GKN G CS LCL K RSC CP + +
Sbjct: 992 SQMEILANQLTGLMDMKIFYKGKNTGSNACVPRPCSLLCLPKANNSRSCRCPEDVSSSVL 1051
Query: 1049 KDGKTCADGPINY 1061
G D P Y
Sbjct: 1052 PSGDLMCDCPQGY 1064
Score = 180 bits (439), Expect = 3e-44
Identities = 97/266 (36%), Positives = 142/266 (53%), Gaps = 9/266 (3%)
Query: 1085 LPLPPLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLG-THVETVIGNGLHTADGIVIDS 1143
LPL L+ A+ +D D+ +YW+D IQR G T E +I +GL T + + +
Sbjct: 782 LPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEP 841
Query: 1144 TGRKIYWTDGGRNSIEVAELDGRNRKVLVWTG-LDSPRAIALHYEYGYMFWSDWGT-SAK 1201
+ +YW D G IEVA DG R +V + LD PRA+ L + G MFW+DWG
Sbjct: 842 LSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPG 901
Query: 1202 IERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLSN 1261
I R++MDG+ +V +KWPNG+++D + +YW DA + IE F G R +L N
Sbjct: 902 IYRSNMDGSAAYHLVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQQRSVILDN 959
Query: 1262 VPYPYGIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLEGLMDIRAI-QSERVLEN 1320
+P+PY I + IYW DW ++ RA K + S ++ L GLMD++ + + N
Sbjct: 960 LPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGSN 1019
Query: 1321 ACGTDNGGCSHLCL-RSPLGYTCACP 1345
AC CS LCL ++ +C CP
Sbjct: 1020 ACVP--RPCSLLCLPKANNSRSCRCP 1043
Score = 178 bits (433), Expect = 2e-43
Identities = 97/293 (33%), Positives = 161/293 (54%), Gaps = 10/293 (3%)
Query: 1368 EFLIFATRGSITYISLESPEQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSIN 1427
EF+++A R SI L S LP+ ++ +A+D+ ++ ++++DL L+VI+ +
Sbjct: 759 EFILYAVRKSIYRYDLASGATEQ--LPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLC 816
Query: 1428 MTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLITG--LT 1485
+ + + II+ LET L + ++ +YW D K IEVA DG R ++ L
Sbjct: 817 LNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLD 876
Query: 1486 EPRALALFPAKGYLYWSDWGE-HPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLY 1544
PRAL L P +G ++W+DWG+ P I RS +DGS +V D+ +PNG+++D ++ +Y
Sbjct: 877 RPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD--DQWIY 934
Query: 1545 WTDALKDRIDTSDLNGQHRVQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNI 1604
WTDA + I+ +GQ R ++ + +P+ + FK+ IYW DW + SI RA K +G +
Sbjct: 935 WTDAYLECIERITFSGQQRSVILDNLPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQM 994
Query: 1605 TLIRTNLEMAMEIKAVSADRQHGWNPCKESNGGCSHLCLFR-GHEYICACPDD 1656
++ L M++K + G N C CS LCL + + C CP+D
Sbjct: 995 EILANQLTGLMDMKIFYKGKNTGSNACVPR--PCSLLCLPKANNSRSCRCPED 1045
Score = 171 bits (415), Expect = 3e-41
Identities = 94/259 (36%), Positives = 147/259 (56%), Gaps = 7/259 (2%)
Query: 510 CKPTGESPTLLFSNRIGIRQVWL-TGDNYMSVVKGLHNAVALDYHYEKKLVFWSENNLRV 568
C E+ +L++ R I + L +G + GL AVALD+ YE ++WS+ L V
Sbjct: 752 CPLAEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDV 811
Query: 569 IRVAQMNTKNMSDVI-RWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVA 627
I+ +N +VI GLET +A + + LL+W D+G +++EVA DG R +V
Sbjct: 812 IQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVN 871
Query: 628 ND-LDKPRAIAVHPGDALVFWTDWGP-NPKIERADMDGDKRKTVIYDEIFWPNGLTIDYT 685
+ LD+PRA+ + P + ++FWTDWG P I R++MDG ++ +++ WPNG+++D
Sbjct: 872 SSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD-- 929
Query: 686 ESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNK 745
+ IYW DA IER F G+ +R V LPHP+A+ +F + IYW DW SI +K
Sbjct: 930 DQWIYWTDAYLECIERITFSGQ-QRSVILDNLPHPYAIAVFKNEIYWDDWSQLSIFRASK 988
Query: 746 NTGMGIQTVHAGLNVPMDI 764
+G ++ + L MD+
Sbjct: 989 YSGSQMEILANQLTGLMDM 1007
Score = 155 bits (375), Expect = 2e-36
Identities = 103/354 (29%), Positives = 158/354 (44%), Gaps = 52/354 (14%)
Query: 163 NRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTV 222
N+ C + N CI W CD DNDCGD SDE N I D+ T
Sbjct: 1081 NQYRCSNGN-CINSIWWCDFDNDCGDMSDE--------------RNCPTTICDLDTQFRC 1125
Query: 223 LIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQC 282
+ T + + Y+ DN+ E+ +C ++ C + C+ + C
Sbjct: 1126 QESGT--CIPLSYKCDLEDDCGDNSDESHC------EMHQCRSDEYNCSSGMCIRSSWVC 1177
Query: 283 DGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDE--LNCKP 340
DGDNDC DW+DE +C + +C A F+C +G CIP+RW CD + DC DG DE +NC+
Sbjct: 1178 DGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCE- 1236
Query: 341 NSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEE-DQYTCRPQEHLMS 399
+ C + + C + C+ + CDG+RDC++G DE +CE C + C+ ++
Sbjct: 1237 ---KKC--NGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQ---- 1287
Query: 400 NAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGF 459
C+ VCDG+ C G DE+ CS + + K+C C G
Sbjct: 1288 ----QCLFHSMVCDGIIQCRDGSDEDAA--FAGCSQDPEFHKVC-----DEFGFQCQNGV 1336
Query: 460 LLAEDKYSCRDIDEC-MYEQDPVCSQ--TCSNTVGSFRCGCMTGYILRPDERSC 510
++ + C +D+C Y + C N F+ C G+ + P+ C
Sbjct: 1337 CISL-IWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCI-PNRWKC 1388
Score = 142 bits (343), Expect = 1e-32
Identities = 102/353 (28%), Positives = 153/353 (43%), Gaps = 41/353 (11%)
Query: 111 DDAGCIT---PCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTIC 167
D+A C C NF C+ + CIP +R +C++ N C
Sbjct: 1188 DEANCTAIYHTCEASNFQCR-NGHCIP--QRWACDGDTDCQDGSDEDPVNCEKKCNGFRC 1244
Query: 168 HSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALT 227
+ CI CDG DC D SDE +C+ + T + N + + V +
Sbjct: 1245 PN-GTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFM---DFVCKNRQQCLFHSMVCDGII 1300
Query: 228 KPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDND 287
+ C + ++AA + + + C E F+C+N C+ ++CDG +D
Sbjct: 1301 Q----------CRDGSDEDAAFAGCSQDPEFHKV-CDEFGFQCQNGVCISLIWKCDGMDD 1349
Query: 288 CGDWTDEDSC--PMVPGSCNAG-EFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSI- 343
CGD++DE +C P +C+ +F+C +G CIP RW+CD E DC D DE +C + I
Sbjct: 1350 CGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHIL 1409
Query: 344 -------RNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ-- 394
C + Y C+ CV+ TW+CDG RDC +G DE C + + Q
Sbjct: 1410 PFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLG 1469
Query: 395 ----EHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKR--KC-SAEEKCE 440
+ + C+ CDG +DC G DE CP C S E +CE
Sbjct: 1470 RCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCE 1522
Score = 136 bits (330), Expect = 5e-31
Identities = 65/186 (34%), Positives = 94/186 (50%), Gaps = 17/186 (9%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND-GKCIPERW 321
C + C N C+ + CD DNDCGD +DE +CP + +F+C + G CIP +
Sbjct: 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDT-QFRCQESGTCIPLSY 1136
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCE 381
+CD E DC D DE +C+ + C DEY C+ C+ +W+CDG DC + DE NC
Sbjct: 1137 KCDLEDDCGDNSDESHCE---MHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCT 1193
Query: 382 V---SCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEK 438
+CE + CR N +C+ ++ CDG DC G DE+ ++KC+
Sbjct: 1194 AIYHTCEASNFQCR-------NG--HCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRC 1244
Query: 439 CEKLCI 444
CI
Sbjct: 1245 PNGTCI 1250
Score = 125 bits (302), Expect = 1e-27
Identities = 64/192 (33%), Positives = 87/192 (45%), Gaps = 25/192 (13%)
Query: 257 PVELMRCAE-IDFECKNTKCVPKDFQCDGDNDCGDWTDEDSC------PMV---PGSCNA 306
P E C+ F C+N C+P ++CD +NDCGDW+DE C P P +C
Sbjct: 1362 PTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLP 1421
Query: 307 GEFKCNDGKCIPERWRCDNERDCADGGDELNCK----------PNSIRNCSLDEYTCADR 356
++C+ G C+ + W CD RDCADG DE C P + C E+ C
Sbjct: 1422 NYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQP 1481
Query: 357 RCVLKTWL-CDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGM 415
+ + W CDG +DC +G DE NC TC +E + C+ CDG
Sbjct: 1482 KTCIPNWKRCDGHQDCQDGRDEANCPT---HSTLTCMSREFQCEDG-EACIVLSERCDGF 1537
Query: 416 KDCPRGDDEERC 427
DC DE+ C
Sbjct: 1538 LDCSDESDEKAC 1549
Score = 90.2 bits (214), Expect = 6e-17
Identities = 65/220 (29%), Positives = 93/220 (42%), Gaps = 33/220 (15%)
Query: 279 DFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNC 338
D CD G ++C +C +++C++G CI W CD + DC D DE NC
Sbjct: 1055 DLMCDCPQ--GYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC 1112
Query: 339 KPNSIRNCSLD-EYTCADR-RCVLKTWLCDGVRDCTNGEDEMNCEV-SCEEDQYTCRPQE 395
P +I C LD ++ C + C+ ++ CD DC + DE +CE+ C D+Y C
Sbjct: 1113 -PTTI--CDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNC---- 1165
Query: 396 HLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACAC 455
S+ C+ VCDG DC DE C + CE +GH
Sbjct: 1166 ---SSGM--CIRSSWVCDGDNDCRDWSDEANC-----TAIYHTCEASNFQCRNGH---CI 1212
Query: 456 PMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRC 495
P + D C+D ++DPV C FRC
Sbjct: 1213 PQRWACDGDT-DCQDGS----DEDPV---NCEKKCNGFRC 1244
Score = 62.1 bits (144), Expect = 2e-08
Identities = 40/131 (30%), Positives = 70/131 (53%), Gaps = 6/131 (4%)
Query: 1155 RNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGN-NRR 1213
R SI +L + L TGL + A+ YE+ ++WSD I+R ++G+ +
Sbjct: 766 RKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDV-IQRLCLNGSTGQE 824
Query: 1214 VIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLSN--VPYPYGIVIV 1271
VI+++ ++ LA + + LYW DA IE ++ DG R T++++ + P +V+V
Sbjct: 825 VIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLV 884
Query: 1272 GQH--IYWTDW 1280
Q ++WTDW
Sbjct: 885 PQEGVMFWTDW 895
Score = 58.0 bits (134), Expect = 3e-07
Identities = 33/92 (35%), Positives = 45/92 (48%), Gaps = 8/92 (8%)
Query: 111 DDAGCITP-C-LKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTICH 168
D+ C T C L F CQ S TCIP+ + C+ H+ R+ +
Sbjct: 1108 DERNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESH----CEMHQCRSDEY 1163
Query: 169 --STNVCIALEWLCDGDNDCGDFSDEINCDVV 198
S+ +CI W+CDGDNDC D+SDE NC +
Sbjct: 1164 NCSSGMCIRSSWVCDGDNDCRDWSDEANCTAI 1195
Score = 36.7 bits (81), Expect = 0.76
Identities = 26/83 (31%), Positives = 28/83 (33%), Gaps = 10/83 (12%)
Query: 119 CLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTI------CHSTNV 172
C + F C TCIP KR +C H T C
Sbjct: 1471 CDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEA----NCPTHSTLTCMSREFQCEDGEA 1526
Query: 173 CIALEWLCDGDNDCGDFSDEINC 195
CI L CDG DC D SDE C
Sbjct: 1527 CIVLSERCDGFLDCSDESDEKAC 1549
>M30269-1|AAA59932.1| 1247|Homo sapiens nidogen protein.
Length = 1247
Score = 181 bits (441), Expect = 2e-44
Identities = 103/303 (33%), Positives = 154/303 (50%), Gaps = 7/303 (2%)
Query: 1366 PEEFLIFATRGSITYISLESPEQWDVTLPV-KEVKNTIAVDYHWDL--KMIFYTDLDLNV 1422
P L+FA G I + LE V + + +D KM+++TD+
Sbjct: 942 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS 1001
Query: 1423 IRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLI- 1481
I ++ E TII Q L +P G+ VD + NI+WTD+ IEVA+LDG+ R+VL
Sbjct: 1002 IGRASLHG-GEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFE 1060
Query: 1482 TGLTEPRALALFPAKGYLYWSDWG-EHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKE 1540
T L PR + +G LYW+DW ++P IE SY+DG+ R+I+VQ DLG PNGL D
Sbjct: 1061 TDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFS 1120
Query: 1541 RRLYWTDALKDRIDTSDLNGQHRVQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRT 1600
+L W DA +R + + + R + + + PF +T + +Y+TDW S++ D
Sbjct: 1121 SQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAI 1180
Query: 1601 GKNITLIRTNLEMAM-EIKAVSADRQHGWNPCKESNGGCSHLCLFRGHEYICACPDDPDH 1659
K + + + + I + G N C +NGGC+HLCL C CPD+
Sbjct: 1181 SKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLG 1240
Query: 1660 VEC 1662
V+C
Sbjct: 1241 VDC 1243
Score = 178 bits (433), Expect = 2e-43
Identities = 93/260 (35%), Positives = 137/260 (52%), Gaps = 3/260 (1%)
Query: 1089 PLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKI 1148
P K +G+ D ++YWTD + I RA+ G T+I L + +GI +D GR I
Sbjct: 976 PAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNI 1035
Query: 1149 YWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWG-TSAKIERADM 1207
+WTD + IEVA+LDG R+VL T L +PR I G ++W+DW + KIE + M
Sbjct: 1036 FWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYM 1095
Query: 1208 DGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLSNVPYPYG 1267
DG NRR++V + + PNGL D +L W DA E + RR L + YP+
Sbjct: 1096 DGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFA 1155
Query: 1268 IVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLE-GLMDIRAIQSERVL-ENACGTD 1325
+ G+++Y+TDWK ++ D + + + + + L I S+ N C +
Sbjct: 1156 VTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVN 1215
Query: 1326 NGGCSHLCLRSPLGYTCACP 1345
NGGC+HLCL +P TC CP
Sbjct: 1216 NGGCTHLCLATPGSRTCRCP 1235
Score = 173 bits (422), Expect = 4e-42
Identities = 94/258 (36%), Positives = 135/258 (52%), Gaps = 24/258 (9%)
Query: 809 KSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYW 868
K + L +D ++WTD+ + +I RA L+G TTI+ +L P G+A D + I+W
Sbjct: 978 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFW 1037
Query: 869 TDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGA-SPCIERADMDG 927
TD +RIEV+K DG+ R +L + PR IV + G +YW+DW +P IE + MDG
Sbjct: 1038 TDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDG 1097
Query: 928 GNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIENLPHPFGLD 987
NR+ L+ + PNGL D +++ W D G E N R K +E L +PF +
Sbjct: 1098 TNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVT 1157
Query: 988 LYGDEVFWTDWDTQSI----QAANKDTGA-----KRRTLG--------------CGKNNG 1024
YG +++TDW S+ A +K+T A + R G C NNG
Sbjct: 1158 SYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNG 1217
Query: 1025 GCSHLCLLKPGGRSCACP 1042
GC+HLCL PG R+C CP
Sbjct: 1218 GCTHLCLATPGSRTCRCP 1235
Score = 136 bits (330), Expect = 5e-31
Identities = 72/194 (37%), Positives = 107/194 (55%), Gaps = 2/194 (1%)
Query: 548 VALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDS 607
+ L + K+V+W++ I A ++ + +IR L +P G+AVD + +FWTDS
Sbjct: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDS 1040
Query: 608 GTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWG-PNPKIERADMDGDKR 666
R+EVA LDG++R VL DL PR I ++WTDW NPKIE + MDG R
Sbjct: 1041 NLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNR 1100
Query: 667 KTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLF 726
+ ++ D++ PNGL D S++ W DA + E RRK +GL +PFA+T +
Sbjct: 1101 RILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRK-ALEGLQYPFAVTSY 1159
Query: 727 DDAIYWTDWHTKSI 740
+Y+TDW S+
Sbjct: 1160 GKNLYFTDWKMNSV 1173
Score = 49.2 bits (112), Expect = 1e-04
Identities = 29/60 (48%), Positives = 35/60 (58%), Gaps = 6/60 (10%)
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVC-SQT-CSNTVGSFRCGCMTGYILRPDERSC 510
C C +GF D +C DIDEC EQ VC S T C+N G+FRC C+ GY DE +C
Sbjct: 695 CECSIGF--RGDGRTCYDIDECS-EQPSVCGSHTICNNHPGTFRCECVEGYQF-SDEGTC 750
Score = 44.4 bits (100), Expect = 0.004
Identities = 25/61 (40%), Positives = 30/61 (49%), Gaps = 7/61 (11%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQT--CSNTVGSFRCGCMTG 500
CI T C+C GF + D +C+D+DEC Q C C NT GSF C C G
Sbjct: 777 CIYTGGSSYTCSCLPGF--SGDGQACQDVDEC---QPSRCHPDAFCYNTPGSFTCQCKPG 831
Query: 501 Y 501
Y
Sbjct: 832 Y 832
>X55077-1|CAA38905.1| 591|Homo sapiens alpha-2 macroglobulin
receptor protein.
Length = 591
Score = 173 bits (422), Expect = 4e-42
Identities = 99/297 (33%), Positives = 142/297 (47%), Gaps = 34/297 (11%)
Query: 169 STNVCIALEWLCDGDNDCGDFSDEINCDV----------VKTSLLVPS---ANASLNIGD 215
ST +C ++CDGDNDC D SDE NCD+ T+ +P N N GD
Sbjct: 108 STGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGD 167
Query: 216 VITN---PTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVEL--MRCAEIDFEC 270
P V A + I D + ++P M C +F C
Sbjct: 168 GEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRC 227
Query: 271 KNT-KCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDC 329
K++ +C+P ++CDG++DCGD +DE +C +F+C + +C+P RW+CD + DC
Sbjct: 228 KDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDC 287
Query: 330 ADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQY 389
D DE +C P R CS E++CA+ RC+ W CDG DC +G DE +C C+ DQ+
Sbjct: 288 GDNSDEESCTP---RPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQF 344
Query: 390 TCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPL-KRKCSAEE-KCEK-LC 443
C+ +C+ + CD DC G DEE C R C +E +C LC
Sbjct: 345 QCKS---------GHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLC 392
Score = 151 bits (367), Expect = 2e-35
Identities = 88/261 (33%), Positives = 127/261 (48%), Gaps = 16/261 (6%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
RC F+CK+ C+P ++CD D DC D +DE++C +C EF+CN+ C P W
Sbjct: 338 RCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAW 397
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDE-YTCA-DRRCVLKTWLCDGVRDCTNGEDEMN 379
+CD E DC D DE N + + C + + C DR C+ CDG +C +G DE +
Sbjct: 398 KCDGEDDCGDNSDE-NPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEED 456
Query: 380 CEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRK---CSAE 436
CE + +E L N + C++ C+ DC G DEE C + K C+
Sbjct: 457 CEPPTAHTTHCKDKKEFLCRN--QRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATN 514
Query: 437 EK-C--EKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSF 493
C E C+ T + A CAC GF + C+DI+EC+ + CSQ C+NT G
Sbjct: 515 ASICGDEARCVRT-EKAAYCACRSGFHTVPGQPGCQDINECL--RFGTCSQLCNNTKGGH 571
Query: 494 RCGCMTGYILRPDERSCKPTG 514
C C ++ +CK G
Sbjct: 572 LCSCARNFM--KTHNTCKAEG 590
Score = 125 bits (301), Expect = 2e-27
Identities = 64/182 (35%), Positives = 94/182 (51%), Gaps = 17/182 (9%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDE-DSCPMVPGSCNAGEFKCNDGKCIPERW 321
C F CKN KC+P ++CD ++DCGD +DE CP C G+F+C+ G C +
Sbjct: 60 CTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEF--KCRPGQFQCSTGICTNPAF 117
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNC 380
CD + DC D DE NC I C ++ C + RC+ + C+G +C +GEDE +C
Sbjct: 118 ICDGDNDCQDNSDEANC---DIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDC 174
Query: 381 -EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE-K 438
EV+C +Q+ C + + C+ R VCD DC G DE + C +E +
Sbjct: 175 PEVTCAPNQFQC--------SITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFR 226
Query: 439 CE 440
C+
Sbjct: 227 CK 228
Score = 124 bits (298), Expect = 4e-27
Identities = 88/281 (31%), Positives = 120/281 (42%), Gaps = 43/281 (15%)
Query: 173 CIALEWLCDGDNDCGDFSDE-INCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTV 231
CI W CD ++DCGD SDE +C K + G + TNP +
Sbjct: 72 CIPFWWKCDTEDDCGDHSDEPPDCPEFKCR----PGQFQCSTG-ICTNPAFICDGDNDCQ 126
Query: 232 VIRYESFC-AKKALDNAANPRSTWNQPVELMRC--------AEIDFECKNTKCVPKDFQ- 281
E+ C L + +T + RC E + +C C P FQ
Sbjct: 127 DNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQC 186
Query: 282 ------------CDGDNDCGDWTDED-SCPMVPGSCNAGEFKCND-GKCIPERWRCDNER 327
CD DNDC D +DE +C + +C EF+C D G+CIP RW+CD E
Sbjct: 187 SITKRCIPRVWVCDRDNDCVDGSDEPANCTQM--TCGVDEFRCKDSGRCIPARWKCDGED 244
Query: 328 DCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV-SCEE 386
DC DG DE + + R C ++ C + RCV W CD DC + DE +C C E
Sbjct: 245 DCGDGSDEPKEECDE-RTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSE 303
Query: 387 DQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC 427
+++C A C+ + CDG DC G DE+ C
Sbjct: 304 SEFSC---------ANGRCIAGRWKCDGDHDCADGSDEKDC 335
Score = 118 bits (283), Expect = 3e-25
Identities = 64/183 (34%), Positives = 95/183 (51%), Gaps = 22/183 (12%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKC-NDGKCIPER 320
+C F+C C F CDGDNDC D +DE +C + C +FKC N +CIP
Sbjct: 99 KCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDI--HVCLPSQFKCTNTNRCIPGI 156
Query: 321 WRCDNERDCADGGDELNCKPNSIRNCSLDEYTCA-DRRCVLKTWLCDGVRDCTNGEDE-M 378
+RC+ + +C DG DE +C P C+ +++ C+ +RC+ + W+CD DC +G DE
Sbjct: 157 FRCNGQDNCGDGEDERDC-PEV--TCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPA 213
Query: 379 NC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE 437
NC +++C D++ C+ C+ + CDG DC G DE K +C E
Sbjct: 214 NCTQMTCGVDEFRCKDS--------GRCIPARWKCDGEDDCGDGSDEP----KEECD-ER 260
Query: 438 KCE 440
CE
Sbjct: 261 TCE 263
Score = 92.7 bits (220), Expect = 1e-17
Identities = 54/188 (28%), Positives = 83/188 (44%), Gaps = 27/188 (14%)
Query: 303 SCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKT 362
+C A +F C + KCIP W+CD E DC D DE P C ++ C+ C
Sbjct: 59 NCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEF--KCRPGQFQCSTGICTNPA 116
Query: 363 WLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGD 422
++CDG DC + DE NC++ + C P + +N R C+ C+G +C G+
Sbjct: 117 FICDGDNDCQDNSDEANCDI------HVCLPSQFKCTNTNR-CIPGIFRCNGQDNCGDGE 169
Query: 423 DEERC------PLKRKCSAEEKC---------EKLCITTYDGHAACACPMGFLLAEDKYS 467
DE C P + +CS ++C + C+ D A C D++
Sbjct: 170 DERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCT---QMTCGVDEFR 226
Query: 468 CRDIDECM 475
C+D C+
Sbjct: 227 CKDSGRCI 234
Score = 74.9 bits (176), Expect = 2e-12
Identities = 75/267 (28%), Positives = 108/267 (40%), Gaps = 34/267 (12%)
Query: 102 DGPLNEGTEDDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEH 161
D + +++++ PC + FSC + CI + CD
Sbjct: 284 DNDCGDNSDEESCTPRPCSESEFSCA-NGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMD 342
Query: 162 ENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDV-VKTSLLVPSANASLNIGDVITNP 220
+ + C S + CI L W CD D DC D SDE C V+T L + N
Sbjct: 343 QFQ--CKSGH-CIPLRWRCDADADCMDGSDEEACGTGVRTCPL----------DEFQCNN 389
Query: 221 TVLIALTKPTV-VIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTK-CVPK 278
T L KP E C + +N P RC KN + C+
Sbjct: 390 T----LCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRC-------KNDRVCLWI 438
Query: 279 DFQCDGDNDCGDWTDEDSC-PMVPGS--C-NAGEFKCNDGKCIPERWRCDNERDCADGGD 334
QCDG ++CGD TDE+ C P + C + EF C + +C+ RC+ DC DG D
Sbjct: 439 GRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSD 498
Query: 335 ELNCKPN-SIRNCSLDEYTCADR-RCV 359
E +C + + +C+ + C D RCV
Sbjct: 499 EEDCSIDPKLTSCATNASICGDEARCV 525
Score = 59.3 bits (137), Expect = 1e-07
Identities = 29/97 (29%), Positives = 43/97 (44%), Gaps = 7/97 (7%)
Query: 343 IRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAF 402
+ NC+ ++ C + +C+ W CD DC + DE C E + CRP + S
Sbjct: 57 VSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDE---PPDCPE--FKCRPGQFQCSTGI 111
Query: 403 RNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKC 439
C N +CDG DC DE C + ++ KC
Sbjct: 112 --CTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKC 146
Score = 56.4 bits (130), Expect = 9e-07
Identities = 23/37 (62%), Positives = 25/37 (67%), Gaps = 1/37 (2%)
Query: 1019 CGKNNGGCSHLCLLKP-GGRSCACPIGIKLNKDGKTC 1054
C NNGGCS+LCLL P GG CACP L DG+TC
Sbjct: 20 CKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTC 56
Score = 44.8 bits (101), Expect = 0.003
Identities = 33/94 (35%), Positives = 38/94 (40%), Gaps = 9/94 (9%)
Query: 107 EGTEDDAGC-ITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDE---HE 162
+ D+A C I CL F C + CIP R R C E
Sbjct: 126 QDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDE----RDCPEVTCAP 181
Query: 163 NRTICHSTNVCIALEWLCDGDNDCGDFSDE-INC 195
N+ C T CI W+CD DNDC D SDE NC
Sbjct: 182 NQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANC 215
Score = 43.2 bits (97), Expect = 0.009
Identities = 19/37 (51%), Positives = 25/37 (67%), Gaps = 1/37 (2%)
Query: 1311 AIQSERVLENACGTDNGGCSHLCLRSP-LGYTCACPT 1346
A++ V + C +NGGCS+LCL SP G+ CACPT
Sbjct: 9 ALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPT 45
Score = 42.3 bits (95), Expect = 0.015
Identities = 27/86 (31%), Positives = 33/86 (38%), Gaps = 5/86 (5%)
Query: 110 EDDAGCI-TPCLKINFSCQISCTCIPMEK--RXXXXXXXXXXXXXXXXXRSCDEHENRTI 166
ED+ C C F C I+ CIP +C E R
Sbjct: 169 EDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFR-- 226
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDE 192
C + CI W CDG++DCGD SDE
Sbjct: 227 CKDSGRCIPARWKCDGEDDCGDGSDE 252
Score = 39.5 bits (88), Expect = 0.11
Identities = 16/27 (59%), Positives = 20/27 (74%), Gaps = 1/27 (3%)
Query: 1629 NPCKESNGGCSHLCLFR-GHEYICACP 1654
+PCK +NGGCS+LCL G + CACP
Sbjct: 18 HPCKVNNGGCSNLCLLSPGGGHKCACP 44
>AB209448-1|BAD92685.1| 1241|Homo sapiens nidogen (enactin) variant
protein.
Length = 1241
Score = 173 bits (421), Expect = 5e-42
Identities = 102/303 (33%), Positives = 153/303 (50%), Gaps = 12/303 (3%)
Query: 1366 PEEFLIFATRGSITYISLESPEQWDVTLPV-KEVKNTIAVDYHWDL--KMIFYTDLDLNV 1422
P L+FA G I + LE V + + +D KM+++TD+
Sbjct: 941 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS 1000
Query: 1423 IRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLI- 1481
I ++ E TII Q+ G+ VD + NI+WTD+ IEVA+LDG+ R+VL
Sbjct: 1001 IGRASLHG-GEPTTIIRQE-----GIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFE 1054
Query: 1482 TGLTEPRALALFPAKGYLYWSDWG-EHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKE 1540
T L PR + +G LYW+DW ++P IE SY+DG+ R+I+VQ DLG PNGLT D
Sbjct: 1055 TDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFS 1114
Query: 1541 RRLYWTDALKDRIDTSDLNGQHRVQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRT 1600
+L W DA +R + + + R + + + PF +T + +Y+TDW S++ D
Sbjct: 1115 SQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAI 1174
Query: 1601 GKNITLIRTNLEMAM-EIKAVSADRQHGWNPCKESNGGCSHLCLFRGHEYICACPDDPDH 1659
K + + + + I + G N C +NGGC+HLCL C CPD+
Sbjct: 1175 SKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLG 1234
Query: 1660 VEC 1662
V+C
Sbjct: 1235 VDC 1237
Score = 171 bits (415), Expect = 3e-41
Identities = 92/260 (35%), Positives = 135/260 (51%), Gaps = 8/260 (3%)
Query: 1089 PLKNALGVDVDHSTGLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKI 1148
P K +G+ D ++YWTD + I RA+ G T+I +GI +D GR I
Sbjct: 975 PAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQ-----EGIAVDHLGRNI 1029
Query: 1149 YWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGT-SAKIERADM 1207
+WTD + IEVA+LDG R+VL T L +PR I G ++W+DW + KIE + M
Sbjct: 1030 FWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYM 1089
Query: 1208 DGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLSNVPYPYG 1267
DG NRR++V + + PNGL D +L W DA E + RR L + YP+
Sbjct: 1090 DGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFA 1149
Query: 1268 IVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNLE-GLMDIRAIQSERVL-ENACGTD 1325
+ G+++Y+TDWK ++ D + + + + + L I S+ N C +
Sbjct: 1150 VTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVN 1209
Query: 1326 NGGCSHLCLRSPLGYTCACP 1345
NGGC+HLCL +P TC CP
Sbjct: 1210 NGGCTHLCLATPGSRTCRCP 1229
Score = 165 bits (401), Expect = 1e-39
Identities = 92/258 (35%), Positives = 132/258 (51%), Gaps = 29/258 (11%)
Query: 809 KSAVALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYW 868
K + L +D ++WTD+ + +I RA L+G TTI+ G+A D + I+W
Sbjct: 977 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQE-----GIAVDHLGRNIFW 1031
Query: 869 TDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGA-SPCIERADMDG 927
TD +RIEV+K DG+ R +L + PR IV + G +YW+DW +P IE + MDG
Sbjct: 1032 TDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDG 1091
Query: 928 GNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIENLPHPFGLD 987
NR+ L+ + PNGL D +++ W D G E N R K +E L +PF +
Sbjct: 1092 TNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVT 1151
Query: 988 LYGDEVFWTDWDTQSI----QAANKDTGA-----KRRTLG--------------CGKNNG 1024
YG +++TDW S+ A +K+T A + R G C NNG
Sbjct: 1152 SYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNG 1211
Query: 1025 GCSHLCLLKPGGRSCACP 1042
GC+HLCL PG R+C CP
Sbjct: 1212 GCTHLCLATPGSRTCRCP 1229
Score = 128 bits (310), Expect = 1e-28
Identities = 71/194 (36%), Positives = 105/194 (54%), Gaps = 7/194 (3%)
Query: 548 VALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDS 607
+ L + K+V+W++ I A ++ + +IR G+AVD + +FWTDS
Sbjct: 980 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIR-----QEGIAVDHLGRNIFWTDS 1034
Query: 608 GTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWG-PNPKIERADMDGDKR 666
R+EVA LDG++R VL DL PR I ++WTDW NPKIE + MDG R
Sbjct: 1035 NLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNR 1094
Query: 667 KTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLF 726
+ ++ D++ PNGLT D S++ W DA + E RRK +GL +PFA+T +
Sbjct: 1095 RILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRK-ALEGLQYPFAVTSY 1153
Query: 727 DDAIYWTDWHTKSI 740
+Y+TDW S+
Sbjct: 1154 GKNLYFTDWKMNSV 1167
Score = 49.2 bits (112), Expect = 1e-04
Identities = 29/60 (48%), Positives = 35/60 (58%), Gaps = 6/60 (10%)
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVC-SQT-CSNTVGSFRCGCMTGYILRPDERSC 510
C C +GF D +C DIDEC EQ VC S T C+N G+FRC C+ GY DE +C
Sbjct: 694 CECSIGF--RGDGRTCYDIDECS-EQPSVCGSHTICNNHPGTFRCECVEGYQF-SDEGTC 749
Score = 43.6 bits (98), Expect = 0.007
Identities = 23/59 (38%), Positives = 29/59 (49%), Gaps = 3/59 (5%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGY 501
CI T C+C GF + D +C+D+DEC + C NT GSF C C GY
Sbjct: 776 CIYTGGSSYTCSCLPGF--SGDGQACQDVDEC-HPSRCHPDAFCYNTPGSFTCQCKPGY 831
>BC139736-1|AAI39737.1| 224|Homo sapiens LRP5L protein protein.
Length = 224
Score = 172 bits (419), Expect = 8e-42
Identities = 83/217 (38%), Positives = 129/217 (59%), Gaps = 2/217 (0%)
Query: 1103 GLIYWTDTGQRKIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGRNSIEVAE 1162
G +YWTD I+RA G+ +T+I ++ D I ++ R +YWT G IEV
Sbjct: 3 GHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTC 62
Query: 1163 LDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVIVDNKIKW 1222
L+ + K+LV +D PRAIALH E G +W DWG + +I+RA++D RV+V+ + W
Sbjct: 63 LNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGW 122
Query: 1223 PNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLSN-VPYPYGIVIVGQHIYWTDWK 1281
PNGLA+D EG+LYW DAK IE+ D R+T+L + +P+ + ++G IYWT W+
Sbjct: 123 PNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQ 182
Query: 1282 TKALHRADKTNASDPIVIRKNLEGLMDIRAIQSERVL 1318
++ R K A+ ++I L LM ++A+ ++V+
Sbjct: 183 HHSIKRVHKVKANRDVII-DQLPDLMGLKAVNVDKVV 218
Score = 170 bits (413), Expect = 4e-41
Identities = 73/187 (39%), Positives = 111/187 (59%)
Query: 559 VFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLD 618
V+W+++ + IR A ++ +I + P +AV+W+ L+WT +GT +EV L+
Sbjct: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
Query: 619 GSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPN 678
+ +LV+ D+D+PRAIA+HP L +W DWG NP+I+RA++D + + ++ + WPN
Sbjct: 65 STSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPN 124
Query: 679 GLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFDDAIYWTDWHTK 738
GL +D E K+YW DAK IE + D R+ + LPH F TL D IYWT W
Sbjct: 125 GLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQHH 184
Query: 739 SISTVNK 745
SI V+K
Sbjct: 185 SIKRVHK 191
Score = 162 bits (393), Expect = 1e-38
Identities = 74/187 (39%), Positives = 112/187 (59%), Gaps = 1/187 (0%)
Query: 823 IFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTNRIEVSKSD 882
++WTD E I RAYL+GS T++++ + P +A +W+ +YWT GT IEV+ +
Sbjct: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
Query: 883 GSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKLIFGQMTWPN 942
+ +L + +D+PR I ++PE G+ YW DWG +P I+RA++D + L+ + WPN
Sbjct: 65 STSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPN 124
Query: 943 GLALDLVHNRIYWTDGGNKTIEYANLDGTGR-TKLIENLPHPFGLDLYGDEVFWTDWDTQ 1001
GLALDL ++YW D IE ++D T R T L + LPH F L GD ++WT W
Sbjct: 125 GLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQHH 184
Query: 1002 SIQAANK 1008
SI+ +K
Sbjct: 185 SIKRVHK 191
Score = 157 bits (380), Expect = 4e-37
Identities = 81/217 (37%), Positives = 128/217 (58%), Gaps = 4/217 (1%)
Query: 1413 IFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARL 1472
+++TD ++ IR + S ++T+I+ K+ P+ + V+W+A ++YWT + IEV L
Sbjct: 5 VYWTDDEVWAIRRAYLDG-SGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCL 63
Query: 1473 DGSSRKVLIT-GLTEPRALALFPAKGYLYWSDWGEHPYIERSYLDGSQRQIIVQVDLGFP 1531
+ +S K+L++ + EPRA+AL P G YW DWGE+P I+R+ LD + +++V LG+P
Sbjct: 64 NSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWP 123
Query: 1532 NGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQLVPD-AKNPFGMTQFKDYIYWTDWYK 1590
NGL +D +E +LYW DA D+I+ ++ R L+ D + F T D+IYWT W
Sbjct: 124 NGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQH 183
Query: 1591 KSIIRADKRTGKNITLIRTNLEMAMEIKAVSADRQHG 1627
SI R K N +I L M +KAV+ D+ G
Sbjct: 184 HSIKRVHK-VKANRDVIIDQLPDLMGLKAVNVDKVVG 219
Score = 67.7 bits (158), Expect = 4e-10
Identities = 51/156 (32%), Positives = 70/156 (44%), Gaps = 6/156 (3%)
Query: 866 IYWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADM 925
+YWTD I + DGS L I+ P DI VN +YW+ G IE +
Sbjct: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEH-IEVTCL 63
Query: 926 DGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGG-NKTIEYANLDGTGRTKLIE---NLP 981
+ + K L+ M P +AL YW D G N I+ ANLD L+ P
Sbjct: 64 NSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWP 123
Query: 982 HPFGLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTL 1017
+ LDL +++W D T I+A + D KR+TL
Sbjct: 124 NGLALDLQEGKLYWGDAKTDKIEAISVDE-TKRQTL 158
Score = 56.8 bits (131), Expect = 7e-07
Identities = 42/176 (23%), Positives = 78/176 (44%), Gaps = 6/176 (3%)
Query: 812 VALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDG 871
+A++W + S++WT + I LN + +V ++ P +A YW D
Sbjct: 39 IAVNW--VARSLYWTHTGTEHIEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDW 96
Query: 872 GTN-RIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNR 930
G N I+ + D +L + P + ++ + G +YW D + IE +D R
Sbjct: 97 GENPEIKRANLDRQELRVLVNASLGWPNGLALDLQEGKLYWGD-AKTDKIEAISVDETKR 155
Query: 931 KKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIENLPHPFGL 986
+ L+ ++ P+ L+ + IYWT + +I+ + R +I+ LP GL
Sbjct: 156 QTLLKDKL--PHIFRFTLLGDFIYWTAWQHHSIKRVHKVKANRDVIIDQLPDLMGL 209
Score = 54.8 bits (126), Expect = 3e-06
Identities = 44/161 (27%), Positives = 72/161 (44%), Gaps = 6/161 (3%)
Query: 1456 NIYWTDNEHKVIEVARLDGSSRKVLI-TGLTEPRALALFPAKGYLYWSDWGEHPYIERSY 1514
++YWTD+E I A LDGS + LI T + +P +A+ LYW+ G +IE +
Sbjct: 4 HVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTE-HIEVTC 62
Query: 1515 LDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTD-ALKDRIDTSDLNGQHRVQLVPDA--- 1570
L+ + +I+V D+ P + + + YW D I ++L+ Q LV +
Sbjct: 63 LNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGW 122
Query: 1571 KNPFGMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNL 1611
N + + +YW D I K TL++ L
Sbjct: 123 PNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKL 163
Score = 37.1 bits (82), Expect = 0.57
Identities = 18/77 (23%), Positives = 39/77 (50%), Gaps = 3/77 (3%)
Query: 1231 IEGRLYWNDAKILTIESSDFDGHDRRTVLS---NVPYPYGIVIVGQHIYWTDWKTKALHR 1287
+EG +YW D ++ I + DG +T+++ N P + V + +YWT T+ +
Sbjct: 1 MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
Query: 1288 ADKTNASDPIVIRKNLE 1304
+ S I++ ++++
Sbjct: 61 TCLNSTSHKILVSEDMD 77
Score = 33.5 bits (73), Expect = 7.0
Identities = 18/59 (30%), Positives = 27/59 (45%), Gaps = 3/59 (5%)
Query: 949 VHNRIYWTDGGNKTIEYANLDGTGRTKLIE---NLPHPFGLDLYGDEVFWTDWDTQSIQ 1004
+ +YWTD I A LDG+G LI N P ++ ++WT T+ I+
Sbjct: 1 MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIE 59
>S73145-1|AAB30825.1| 268|Homo sapiens calcium sensor protein
protein.
Length = 268
Score = 171 bits (415), Expect = 3e-41
Identities = 90/225 (40%), Positives = 125/225 (55%), Gaps = 8/225 (3%)
Query: 1137 DGIVIDSTGRKIYWTDGGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDW 1196
DGI +D GR IYW+D IEVA+LDGR RK L+ T LD P AIA++ + G MFW+DW
Sbjct: 7 DGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDW 66
Query: 1197 GTSAKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEG-RLYWNDAKILTIESSDFDGHDR 1255
G KIE A M+G +R ++V + WP GL+ID + R+YW+D K IE+ +DG DR
Sbjct: 67 GKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDR 126
Query: 1256 RTVLSNVPYPYGIVIVGQHIYWTDWKTKALHRADK---TNASDPIVIRKNLEGLMDIRAI 1312
R + PY + I +YW + + + +K +V+ L + +
Sbjct: 127 RVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFHQL 186
Query: 1313 QSERVLENACGTDNGGCSHLCLRSPLGYTCACPTGMPF-EKSTTD 1356
+ + + N C CSHLCL P GY+CACP G F E STT+
Sbjct: 187 RYNKSVPNLC---KQICSHLCLLRPGGYSCACPQGSSFIEGSTTE 228
Score = 169 bits (410), Expect = 1e-40
Identities = 88/226 (38%), Positives = 131/226 (57%), Gaps = 7/226 (3%)
Query: 1445 PNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLI-TGLTEPRALALFPAKGYLYWSD 1503
P+G+ VDW+ +IYW+D ++K IEVA+LDG RK LI T L +P A+A+ P G ++W+D
Sbjct: 6 PDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTD 65
Query: 1504 WGEHPYIERSYLDGSQRQIIVQVDLGFPNGLTIDY-KERRLYWTDALKDRIDTSDLNGQH 1562
WG+ P IE ++++G R I+V DLG+P GL+IDY R+YW+D +D I+T +G
Sbjct: 66 WGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTD 125
Query: 1563 RVQLVPDAKNPFGMTQFKDYIYWTDWYKKSIIRADK--RTGKNITLIRTNLEMAMEIKAV 1620
R + +A NP+ + F+D +YW K + + +K + K TL+ + I
Sbjct: 126 RRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFHQ 185
Query: 1621 SADRQHGWNPCKESNGGCSHLCLFRGHEYICACPDDPDHVECSTVK 1666
+ N CK+ CSHLCL R Y CACP +E ST +
Sbjct: 186 LRYNKSVPNLCKQI---CSHLCLLRPGGYSCACPQGSSFIEGSTTE 228
Score = 160 bits (389), Expect = 4e-38
Identities = 87/228 (38%), Positives = 121/228 (53%), Gaps = 22/228 (9%)
Query: 854 PAGLAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSD 913
P G+A DW+ IYW+D RIEV+K DG R L +D+P I VNP+ G+M+W+D
Sbjct: 6 PDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTD 65
Query: 914 WGASPCIERADMDGGNRKKLIFGQMTWPNGLALDLVHN-RIYWTDGGNKTIEYANLDGTG 972
WG P IE A M+G +R L+F + WP GL++D ++N RIYW+D IE DGT
Sbjct: 66 WGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTD 125
Query: 973 RTKLIENLPHPFGLDLYGDEVFWTDWDTQSIQAANK-DTGAKRRTLGCG----------- 1020
R + + +P+ LD++ D+++W + + NK G K +TL
Sbjct: 126 RRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFHQ 185
Query: 1021 -KNNGG--------CSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPI 1059
+ N CSHLCLL+PGG SCACP G + T D I
Sbjct: 186 LRYNKSVPNLCKQICSHLCLLRPGGYSCACPQGSSFIEGSTTECDAAI 233
Score = 159 bits (386), Expect = 8e-38
Identities = 71/157 (45%), Positives = 102/157 (64%), Gaps = 2/157 (1%)
Query: 590 PAGVAVDWIHDLLFWTDSGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTD 649
P G+AVDW+ ++W+D +R+EVA LDG R L++ DLD+P AIAV+P L+FWTD
Sbjct: 6 PDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTD 65
Query: 650 WGPNPKIERADMDGDKRKTVIYDEIFWPNGLTIDY-TESKIYWADAKHHVIERAAFDGRD 708
WG PKIE A M+G+ R ++++++ WP GL+IDY +IYW+D K VIE +DG D
Sbjct: 66 WGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTD 125
Query: 709 RRKVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNK 745
RR V K +P++L +F+D +YW + NK
Sbjct: 126 RR-VIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNK 161
Score = 66.9 bits (156), Expect = 6e-10
Identities = 40/157 (25%), Positives = 82/157 (52%), Gaps = 6/157 (3%)
Query: 559 VFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTR-RVEVATL 617
++WS+ + I VA+++ + +I L+ PA +AV+ L+FWTD G ++E A +
Sbjct: 18 IYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWM 77
Query: 618 DGSKRAVLVANDLDKPRAIAV-HPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFW 676
+G R +LV DL P +++ + + ++W+D+ IE DG R+ + + +
Sbjct: 78 NGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDF-KEDVIETIKYDGTDRRVIAKEAM-- 134
Query: 677 PNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVT 713
N ++D E ++YW + + + G+ +++ T
Sbjct: 135 -NPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKT 170
Score = 66.1 bits (154), Expect = 1e-09
Identities = 43/164 (26%), Positives = 81/164 (49%), Gaps = 8/164 (4%)
Query: 812 VALDWDQKSNSIFWTDVEKDTINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDG 871
+A+DW I+W+DV+ I A L+G ++ ++ ++L PA +A + ++WTD
Sbjct: 9 IAVDW--VGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDW 66
Query: 872 GTN-RIEVSKSDGSMRTLLAWDHIDKPRDIVVN-PEGGVMYWSDWGASPCIERADMDGGN 929
G +IE + +G R +L ++ + P + ++ +YWSD+ IE DG +
Sbjct: 67 GKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDF-KEDVIETIKYDGTD 125
Query: 930 RKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGR 973
R+ + M N +LD+ +++YW + N G G+
Sbjct: 126 RRVIAKEAM---NPYSLDIFEDQLYWISKEKGEVWKQNKFGQGK 166
Score = 52.0 bits (119), Expect = 2e-05
Identities = 28/93 (30%), Positives = 48/93 (51%), Gaps = 3/93 (3%)
Query: 1410 LKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGLGVDWIANN-IYWTDNEHKVIE 1468
L ++F+TD N + ++ + L P GL +D++ N+ IYW+D + VIE
Sbjct: 58 LGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIE 117
Query: 1469 VARLDGSSRKVLITGLTEPRALALFPAKGYLYW 1501
+ DG+ R+V+ P +L +F + LYW
Sbjct: 118 TIKYDGTDRRVIAKEAMNPYSLDIF--EDQLYW 148
Score = 50.0 bits (114), Expect = 8e-05
Identities = 22/64 (34%), Positives = 36/64 (56%), Gaps = 2/64 (3%)
Query: 674 IFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTLFD--DAIY 731
+ P+G+ +D+ IYW+D K+ IE A DGR R+ + + L P A+ + ++
Sbjct: 3 VMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMF 62
Query: 732 WTDW 735
WTDW
Sbjct: 63 WTDW 66
Score = 44.4 bits (100), Expect = 0.004
Identities = 26/84 (30%), Positives = 42/84 (50%), Gaps = 2/84 (2%)
Query: 1090 LKNALGVDVDHSTGLIYWTDTGQR-KIQRATRLGTHVETVIGNGLHTADGIVIDSTGR-K 1147
L + V+ GL++WTD G+ KI+ A G ++ L G+ ID +
Sbjct: 46 LDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDR 105
Query: 1148 IYWTDGGRNSIEVAELDGRNRKVL 1171
IYW+D + IE + DG +R+V+
Sbjct: 106 IYWSDFKEDVIETIKYDGTDRRVI 129
Score = 43.2 bits (97), Expect = 0.009
Identities = 20/61 (32%), Positives = 36/61 (59%), Gaps = 3/61 (4%)
Query: 1223 PNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLS-NVPYPYGIVIVGQ--HIYWTD 1279
P+G+A+D + +YW+D K IE + DG R+ ++S ++ P I + + ++WTD
Sbjct: 6 PDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTD 65
Query: 1280 W 1280
W
Sbjct: 66 W 66
>D86425-1|BAA13087.1| 1376|Homo sapiens osteonidogen protein.
Length = 1376
Score = 164 bits (399), Expect = 2e-39
Identities = 81/199 (40%), Positives = 114/199 (57%), Gaps = 2/199 (1%)
Query: 1094 LGVDVDHSTGLIYWTDTGQRKIQRA-TRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTD 1152
+G+D D ++YWTD R I RA LG ET++ +GL + +G+ ID R +YWTD
Sbjct: 1146 VGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTD 1205
Query: 1153 GGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSA-KIERADMDGNN 1211
+ IE A LDG RKVL +T L +PRAIA+ G ++W+DW A KIE + +DG N
Sbjct: 1206 SVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGEN 1265
Query: 1212 RRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLSNVPYPYGIVIV 1271
RR++++ I PNGL D L W DA +E + DG RR + +N+ YP+ IV
Sbjct: 1266 RRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFSIVSY 1325
Query: 1272 GQHIYWTDWKTKALHRADK 1290
H Y TDW+ + +K
Sbjct: 1326 ADHFYHTDWRRDGVVSVNK 1344
Score = 163 bits (396), Expect = 5e-39
Identities = 98/276 (35%), Positives = 145/276 (52%), Gaps = 11/276 (3%)
Query: 1335 RSPLGYTCAC-PTGMPFEKSTTDQTPKKCKSHPE--EFLIFATRGSITYISLESPE-QWD 1390
RS G T AC PT P TP+ + P FL++ I Y+ L Q D
Sbjct: 1076 RSQPGTTPACIPTVAP---PMVRPTPRPDVTPPSVGTFLLYTQGQQIGYLPLNGTRLQKD 1132
Query: 1391 VTLPVKEVKNTIAV--DYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGL 1448
+ + +I V DY +M+++TD+ I + +E +TI++ L +P GL
Sbjct: 1133 AAKTLLSLHGSIIVGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGL 1192
Query: 1449 GVDWIANNIYWTDNEHKVIEVARLDGSSRKVLI-TGLTEPRALALFPAKGYLYWSDWG-E 1506
+D I +YWTD+ IE A LDGS RKVL T L PRA+A+ P +G LYW+DW E
Sbjct: 1193 AIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNRE 1252
Query: 1507 HPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQL 1566
P IE S LDG R+I++ D+G PNGLT D + L W DA +++ + +G R +
Sbjct: 1253 APKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVI 1312
Query: 1567 VPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGK 1602
+ K PF + + D+ Y TDW + ++ +K +G+
Sbjct: 1313 QNNLKYPFSIVSYADHFYHTDWRRDGVVSVNKHSGQ 1348
Score = 160 bits (389), Expect = 4e-38
Identities = 82/202 (40%), Positives = 114/202 (56%), Gaps = 2/202 (0%)
Query: 812 VALDWDQKSNSIFWTDVEKDTINRAYLN-GSHQTTIVDSNLIWPAGLAFDWITDKIYWTD 870
V +D+D + ++WTDV TI+RA L G+ TIV+S LI P GLA D I +YWTD
Sbjct: 1146 VGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTD 1205
Query: 871 GGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGA-SPCIERADMDGGN 929
++IE + DGS R +L + + PR I V+P G +YW+DW +P IE + +DG N
Sbjct: 1206 SVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGEN 1265
Query: 930 RKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIENLPHPFGLDLY 989
R+ LI + PNGL D + W D G K +E DGTGR + NL +PF + Y
Sbjct: 1266 RRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFSIVSY 1325
Query: 990 GDEVFWTDWDTQSIQAANKDTG 1011
D + TDW + + NK +G
Sbjct: 1326 ADHFYHTDWRRDGVVSVNKHSG 1347
Score = 148 bits (359), Expect = 2e-34
Identities = 78/203 (38%), Positives = 114/203 (56%), Gaps = 3/203 (1%)
Query: 548 VALDYHYEKKLVFWSENNLRVIRVAQMNT-KNMSDVIRWGLETPAGVAVDWIHDLLFWTD 606
V +DY +++V+W++ R I A + ++ GL +P G+A+D I ++WTD
Sbjct: 1146 VGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTD 1205
Query: 607 SGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPN-PKIERADMDGDK 665
S ++E A LDGS+R VL DL PRAIAV P ++WTDW PKIE + +DG+
Sbjct: 1206 SVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGEN 1265
Query: 666 RKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTL 725
R+ +I +I PNGLT D + WADA +E DG RR V L +PF++
Sbjct: 1266 RRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRR-VIQNNLKYPFSIVS 1324
Query: 726 FDDAIYWTDWHTKSISTVNKNTG 748
+ D Y TDW + +VNK++G
Sbjct: 1325 YADHFYHTDWRRDGVVSVNKHSG 1347
Score = 62.1 bits (144), Expect = 2e-08
Identities = 39/140 (27%), Positives = 67/140 (47%), Gaps = 4/140 (2%)
Query: 540 VVKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIH 599
V GL + L + ++ ++W+++ L I A ++ + L P +AVD I
Sbjct: 1182 VNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIR 1241
Query: 600 DLLFWTDSGTR--RVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIE 657
L+WTD ++E ++LDG R +L+ D+ P + P L+ W D G K+E
Sbjct: 1242 GNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAG-TKKLE 1300
Query: 658 RADMDGDKRKTVIYDEIFWP 677
DG R+ VI + + +P
Sbjct: 1301 CTLPDGTGRR-VIQNNLKYP 1319
Score = 57.2 bits (132), Expect = 5e-07
Identities = 37/116 (31%), Positives = 59/116 (50%), Gaps = 8/116 (6%)
Query: 908 VMYWSDWGASPCIERADMD-GGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYA 966
++YW+D A I RA ++ G + ++ + P GLA+D + +YWTD IE A
Sbjct: 1156 MVYWTDV-AGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESA 1214
Query: 967 NLDGTGRTKLIEN---LPHPFGLDLYGDEVFWTDWDTQS--IQAANKDTGAKRRTL 1017
LDG+ R L P +D ++WTDW+ ++ I+ ++ D G RR L
Sbjct: 1215 LLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLD-GENRRIL 1269
Score = 46.4 bits (105), Expect = 0.001
Identities = 23/50 (46%), Positives = 28/50 (56%), Gaps = 3/50 (6%)
Query: 452 ACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGY 501
+CAC G+ A D + C D+DEC E + TC NT GSF C C GY
Sbjct: 877 SCACLPGY--AGDGHQCTDVDECS-ENRCHPAATCYNTPGSFSCRCQPGY 923
Score = 36.7 bits (81), Expect = 0.76
Identities = 20/61 (32%), Positives = 28/61 (45%), Gaps = 7/61 (11%)
Query: 453 CACPMGFLLAEDKYSCRDIDEC---MYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERS 509
C C G+ D +C D +EC + P + C N GS+RC C +GY D +
Sbjct: 787 CECASGY--QGDGRNCVDENECATGFHRCGP--NSVCINLPGSYRCECRSGYEFADDRHT 842
Query: 510 C 510
C
Sbjct: 843 C 843
>BC035608-1|AAH35608.1| 969|Homo sapiens NID2 protein protein.
Length = 969
Score = 164 bits (399), Expect = 2e-39
Identities = 81/199 (40%), Positives = 114/199 (57%), Gaps = 2/199 (1%)
Query: 1094 LGVDVDHSTGLIYWTDTGQRKIQRA-TRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTD 1152
+G+D D ++YWTD R I RA LG ET++ +GL + +G+ ID R +YWTD
Sbjct: 739 VGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTD 798
Query: 1153 GGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSA-KIERADMDGNN 1211
+ IE A LDG RKVL +T L +PRAIA+ G ++W+DW A KIE + +DG N
Sbjct: 799 SVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGEN 858
Query: 1212 RRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLSNVPYPYGIVIV 1271
RR++++ I PNGL D L W DA +E + DG RR + +N+ YP+ IV
Sbjct: 859 RRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFSIVSY 918
Query: 1272 GQHIYWTDWKTKALHRADK 1290
H Y TDW+ + +K
Sbjct: 919 ADHFYHTDWRRDGVVSVNK 937
Score = 163 bits (396), Expect = 5e-39
Identities = 98/276 (35%), Positives = 145/276 (52%), Gaps = 11/276 (3%)
Query: 1335 RSPLGYTCAC-PTGMPFEKSTTDQTPKKCKSHPE--EFLIFATRGSITYISLESPE-QWD 1390
RS G T AC PT P TP+ + P FL++ I Y+ L Q D
Sbjct: 669 RSQPGTTPACIPTVAP---PMVRPTPRPDVTPPSVGTFLLYTQGQQIGYLPLNGTRLQKD 725
Query: 1391 VTLPVKEVKNTIAV--DYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGL 1448
+ + +I V DY +M+++TD+ I + +E +TI++ L +P GL
Sbjct: 726 AAKTLLSLHGSIIVGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGL 785
Query: 1449 GVDWIANNIYWTDNEHKVIEVARLDGSSRKVLI-TGLTEPRALALFPAKGYLYWSDWG-E 1506
+D I +YWTD+ IE A LDGS RKVL T L PRA+A+ P +G LYW+DW E
Sbjct: 786 AIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNRE 845
Query: 1507 HPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQL 1566
P IE S LDG R+I++ D+G PNGLT D + L W DA +++ + +G R +
Sbjct: 846 APKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVI 905
Query: 1567 VPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGK 1602
+ K PF + + D+ Y TDW + ++ +K +G+
Sbjct: 906 QNNLKYPFSIVSYADHFYHTDWRRDGVVSVNKHSGQ 941
Score = 160 bits (389), Expect = 4e-38
Identities = 82/202 (40%), Positives = 114/202 (56%), Gaps = 2/202 (0%)
Query: 812 VALDWDQKSNSIFWTDVEKDTINRAYLN-GSHQTTIVDSNLIWPAGLAFDWITDKIYWTD 870
V +D+D + ++WTDV TI+RA L G+ TIV+S LI P GLA D I +YWTD
Sbjct: 739 VGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTD 798
Query: 871 GGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGA-SPCIERADMDGGN 929
++IE + DGS R +L + + PR I V+P G +YW+DW +P IE + +DG N
Sbjct: 799 SVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGEN 858
Query: 930 RKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIENLPHPFGLDLY 989
R+ LI + PNGL D + W D G K +E DGTGR + NL +PF + Y
Sbjct: 859 RRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFSIVSY 918
Query: 990 GDEVFWTDWDTQSIQAANKDTG 1011
D + TDW + + NK +G
Sbjct: 919 ADHFYHTDWRRDGVVSVNKHSG 940
Score = 148 bits (359), Expect = 2e-34
Identities = 78/203 (38%), Positives = 114/203 (56%), Gaps = 3/203 (1%)
Query: 548 VALDYHYEKKLVFWSENNLRVIRVAQMNT-KNMSDVIRWGLETPAGVAVDWIHDLLFWTD 606
V +DY +++V+W++ R I A + ++ GL +P G+A+D I ++WTD
Sbjct: 739 VGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTD 798
Query: 607 SGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPN-PKIERADMDGDK 665
S ++E A LDGS+R VL DL PRAIAV P ++WTDW PKIE + +DG+
Sbjct: 799 SVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGEN 858
Query: 666 RKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTL 725
R+ +I +I PNGLT D + WADA +E DG RR V L +PF++
Sbjct: 859 RRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRR-VIQNNLKYPFSIVS 917
Query: 726 FDDAIYWTDWHTKSISTVNKNTG 748
+ D Y TDW + +VNK++G
Sbjct: 918 YADHFYHTDWRRDGVVSVNKHSG 940
Score = 62.1 bits (144), Expect = 2e-08
Identities = 39/140 (27%), Positives = 67/140 (47%), Gaps = 4/140 (2%)
Query: 540 VVKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIH 599
V GL + L + ++ ++W+++ L I A ++ + L P +AVD I
Sbjct: 775 VNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIR 834
Query: 600 DLLFWTDSGTR--RVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIE 657
L+WTD ++E ++LDG R +L+ D+ P + P L+ W D G K+E
Sbjct: 835 GNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAG-TKKLE 893
Query: 658 RADMDGDKRKTVIYDEIFWP 677
DG R+ VI + + +P
Sbjct: 894 CTLPDGTGRR-VIQNNLKYP 912
Score = 57.2 bits (132), Expect = 5e-07
Identities = 37/116 (31%), Positives = 59/116 (50%), Gaps = 8/116 (6%)
Query: 908 VMYWSDWGASPCIERADMD-GGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYA 966
++YW+D A I RA ++ G + ++ + P GLA+D + +YWTD IE A
Sbjct: 749 MVYWTDV-AGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESA 807
Query: 967 NLDGTGRTKLIEN---LPHPFGLDLYGDEVFWTDWDTQS--IQAANKDTGAKRRTL 1017
LDG+ R L P +D ++WTDW+ ++ I+ ++ D G RR L
Sbjct: 808 LLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLD-GENRRIL 862
Score = 46.4 bits (105), Expect = 0.001
Identities = 23/50 (46%), Positives = 28/50 (56%), Gaps = 3/50 (6%)
Query: 452 ACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGY 501
+CAC G+ A D + C D+DEC E + TC NT GSF C C GY
Sbjct: 470 SCACLPGY--AGDGHQCTDVDECS-ENRCHPAATCYNTPGSFSCRCQPGY 516
Score = 34.3 bits (75), Expect = 4.0
Identities = 19/61 (31%), Positives = 27/61 (44%), Gaps = 7/61 (11%)
Query: 453 CACPMGFLLAEDKYSCRDIDEC---MYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERS 509
C C G+ D +C D +EC + P + C N GS+RC C + Y D +
Sbjct: 380 CECASGY--QGDGRNCVDENECATGFHRCGP--NSVCINLPGSYRCECRSAYEFADDRHT 435
Query: 510 C 510
C
Sbjct: 436 C 436
>AJ223500-1|CAA11418.1| 1375|Homo sapiens nidogen-2 protein.
Length = 1375
Score = 164 bits (399), Expect = 2e-39
Identities = 81/199 (40%), Positives = 114/199 (57%), Gaps = 2/199 (1%)
Query: 1094 LGVDVDHSTGLIYWTDTGQRKIQRA-TRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTD 1152
+G+D D ++YWTD R I RA LG ET++ +GL + +G+ ID R +YWTD
Sbjct: 1145 VGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTD 1204
Query: 1153 GGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSA-KIERADMDGNN 1211
+ IE A LDG RKVL +T L +PRAIA+ G ++W+DW A KIE + +DG N
Sbjct: 1205 SVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGEN 1264
Query: 1212 RRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLSNVPYPYGIVIV 1271
RR++++ I PNGL D L W DA +E + DG RR + +N+ YP+ IV
Sbjct: 1265 RRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFSIVSY 1324
Query: 1272 GQHIYWTDWKTKALHRADK 1290
H Y TDW+ + +K
Sbjct: 1325 ADHFYHTDWRRDGVVSVNK 1343
Score = 163 bits (396), Expect = 5e-39
Identities = 98/276 (35%), Positives = 145/276 (52%), Gaps = 11/276 (3%)
Query: 1335 RSPLGYTCAC-PTGMPFEKSTTDQTPKKCKSHPE--EFLIFATRGSITYISLESPE-QWD 1390
RS G T AC PT P TP+ + P FL++ I Y+ L Q D
Sbjct: 1075 RSQPGTTPACIPTVAP---PMVRPTPRPDVTPPSVGTFLLYTQGQQIGYLPLNGTRLQKD 1131
Query: 1391 VTLPVKEVKNTIAV--DYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGL 1448
+ + +I V DY +M+++TD+ I + +E +TI++ L +P GL
Sbjct: 1132 AAKTLLSLHGSIIVGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGL 1191
Query: 1449 GVDWIANNIYWTDNEHKVIEVARLDGSSRKVLI-TGLTEPRALALFPAKGYLYWSDWG-E 1506
+D I +YWTD+ IE A LDGS RKVL T L PRA+A+ P +G LYW+DW E
Sbjct: 1192 AIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNRE 1251
Query: 1507 HPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQL 1566
P IE S LDG R+I++ D+G PNGLT D + L W DA +++ + +G R +
Sbjct: 1252 APKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVI 1311
Query: 1567 VPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGK 1602
+ K PF + + D+ Y TDW + ++ +K +G+
Sbjct: 1312 QNNLKYPFSIVSYADHFYHTDWRRDGVVSVNKHSGQ 1347
Score = 160 bits (389), Expect = 4e-38
Identities = 82/202 (40%), Positives = 114/202 (56%), Gaps = 2/202 (0%)
Query: 812 VALDWDQKSNSIFWTDVEKDTINRAYLN-GSHQTTIVDSNLIWPAGLAFDWITDKIYWTD 870
V +D+D + ++WTDV TI+RA L G+ TIV+S LI P GLA D I +YWTD
Sbjct: 1145 VGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTD 1204
Query: 871 GGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGA-SPCIERADMDGGN 929
++IE + DGS R +L + + PR I V+P G +YW+DW +P IE + +DG N
Sbjct: 1205 SVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGEN 1264
Query: 930 RKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIENLPHPFGLDLY 989
R+ LI + PNGL D + W D G K +E DGTGR + NL +PF + Y
Sbjct: 1265 RRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFSIVSY 1324
Query: 990 GDEVFWTDWDTQSIQAANKDTG 1011
D + TDW + + NK +G
Sbjct: 1325 ADHFYHTDWRRDGVVSVNKHSG 1346
Score = 148 bits (359), Expect = 2e-34
Identities = 78/203 (38%), Positives = 114/203 (56%), Gaps = 3/203 (1%)
Query: 548 VALDYHYEKKLVFWSENNLRVIRVAQMNT-KNMSDVIRWGLETPAGVAVDWIHDLLFWTD 606
V +DY +++V+W++ R I A + ++ GL +P G+A+D I ++WTD
Sbjct: 1145 VGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTD 1204
Query: 607 SGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPN-PKIERADMDGDK 665
S ++E A LDGS+R VL DL PRAIAV P ++WTDW PKIE + +DG+
Sbjct: 1205 SVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGEN 1264
Query: 666 RKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTL 725
R+ +I +I PNGLT D + WADA +E DG RR V L +PF++
Sbjct: 1265 RRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRR-VIQNNLKYPFSIVS 1323
Query: 726 FDDAIYWTDWHTKSISTVNKNTG 748
+ D Y TDW + +VNK++G
Sbjct: 1324 YADHFYHTDWRRDGVVSVNKHSG 1346
Score = 62.1 bits (144), Expect = 2e-08
Identities = 39/140 (27%), Positives = 67/140 (47%), Gaps = 4/140 (2%)
Query: 540 VVKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIH 599
V GL + L + ++ ++W+++ L I A ++ + L P +AVD I
Sbjct: 1181 VNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIR 1240
Query: 600 DLLFWTDSGTR--RVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIE 657
L+WTD ++E ++LDG R +L+ D+ P + P L+ W D G K+E
Sbjct: 1241 GNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAG-TKKLE 1299
Query: 658 RADMDGDKRKTVIYDEIFWP 677
DG R+ VI + + +P
Sbjct: 1300 CTLPDGTGRR-VIQNNLKYP 1318
Score = 57.2 bits (132), Expect = 5e-07
Identities = 37/116 (31%), Positives = 59/116 (50%), Gaps = 8/116 (6%)
Query: 908 VMYWSDWGASPCIERADMD-GGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYA 966
++YW+D A I RA ++ G + ++ + P GLA+D + +YWTD IE A
Sbjct: 1155 MVYWTDV-AGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESA 1213
Query: 967 NLDGTGRTKLIEN---LPHPFGLDLYGDEVFWTDWDTQS--IQAANKDTGAKRRTL 1017
LDG+ R L P +D ++WTDW+ ++ I+ ++ D G RR L
Sbjct: 1214 LLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLD-GENRRIL 1268
Score = 46.4 bits (105), Expect = 0.001
Identities = 23/50 (46%), Positives = 28/50 (56%), Gaps = 3/50 (6%)
Query: 452 ACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGY 501
+CAC G+ A D + C D+DEC E + TC NT GSF C C GY
Sbjct: 876 SCACLPGY--AGDGHQCTDVDECS-ENRCHPAATCYNTPGSFSCRCQPGY 922
Score = 36.7 bits (81), Expect = 0.76
Identities = 20/61 (32%), Positives = 28/61 (45%), Gaps = 7/61 (11%)
Query: 453 CACPMGFLLAEDKYSCRDIDEC---MYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERS 509
C C G+ D +C D +EC + P + C N GS+RC C +GY D +
Sbjct: 786 CECASGY--QGDGRNCVDENECATGFHRCGP--NSVCINLPGSYRCECRSGYEFADDRHT 841
Query: 510 C 510
C
Sbjct: 842 C 842
>AB009799-1|BAA24112.1| 1376|Homo sapiens osteonidogen protein.
Length = 1376
Score = 164 bits (399), Expect = 2e-39
Identities = 81/199 (40%), Positives = 114/199 (57%), Gaps = 2/199 (1%)
Query: 1094 LGVDVDHSTGLIYWTDTGQRKIQRA-TRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTD 1152
+G+D D ++YWTD R I RA LG ET++ +GL + +G+ ID R +YWTD
Sbjct: 1146 VGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTD 1205
Query: 1153 GGRNSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSA-KIERADMDGNN 1211
+ IE A LDG RKVL +T L +PRAIA+ G ++W+DW A KIE + +DG N
Sbjct: 1206 SVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGEN 1265
Query: 1212 RRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIESSDFDGHDRRTVLSNVPYPYGIVIV 1271
RR++++ I PNGL D L W DA +E + DG RR + +N+ YP+ IV
Sbjct: 1266 RRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFSIVSY 1325
Query: 1272 GQHIYWTDWKTKALHRADK 1290
H Y TDW+ + +K
Sbjct: 1326 ADHFYHTDWRRDGVVSVNK 1344
Score = 163 bits (396), Expect = 5e-39
Identities = 98/276 (35%), Positives = 145/276 (52%), Gaps = 11/276 (3%)
Query: 1335 RSPLGYTCAC-PTGMPFEKSTTDQTPKKCKSHPE--EFLIFATRGSITYISLESPE-QWD 1390
RS G T AC PT P TP+ + P FL++ I Y+ L Q D
Sbjct: 1076 RSQPGTTPACIPTVAP---PMVRPTPRPDVTPPSVGTFLLYTQGQQIGYLPLNGTRLQKD 1132
Query: 1391 VTLPVKEVKNTIAV--DYHWDLKMIFYTDLDLNVIRSINMTNMSESKTIISQKLETPNGL 1448
+ + +I V DY +M+++TD+ I + +E +TI++ L +P GL
Sbjct: 1133 AAKTLLSLHGSIIVGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGL 1192
Query: 1449 GVDWIANNIYWTDNEHKVIEVARLDGSSRKVLI-TGLTEPRALALFPAKGYLYWSDWG-E 1506
+D I +YWTD+ IE A LDGS RKVL T L PRA+A+ P +G LYW+DW E
Sbjct: 1193 AIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNRE 1252
Query: 1507 HPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDLNGQHRVQL 1566
P IE S LDG R+I++ D+G PNGLT D + L W DA +++ + +G R +
Sbjct: 1253 APKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVI 1312
Query: 1567 VPDAKNPFGMTQFKDYIYWTDWYKKSIIRADKRTGK 1602
+ K PF + + D+ Y TDW + ++ +K +G+
Sbjct: 1313 QNNLKYPFSIVSYADHFYHTDWRRDGVVSVNKHSGQ 1348
Score = 160 bits (389), Expect = 4e-38
Identities = 82/202 (40%), Positives = 114/202 (56%), Gaps = 2/202 (0%)
Query: 812 VALDWDQKSNSIFWTDVEKDTINRAYLN-GSHQTTIVDSNLIWPAGLAFDWITDKIYWTD 870
V +D+D + ++WTDV TI+RA L G+ TIV+S LI P GLA D I +YWTD
Sbjct: 1146 VGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTD 1205
Query: 871 GGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGA-SPCIERADMDGGN 929
++IE + DGS R +L + + PR I V+P G +YW+DW +P IE + +DG N
Sbjct: 1206 SVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGEN 1265
Query: 930 RKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANLDGTGRTKLIENLPHPFGLDLY 989
R+ LI + PNGL D + W D G K +E DGTGR + NL +PF + Y
Sbjct: 1266 RRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFSIVSY 1325
Query: 990 GDEVFWTDWDTQSIQAANKDTG 1011
D + TDW + + NK +G
Sbjct: 1326 ADHFYHTDWRRDGVVSVNKHSG 1347
Score = 148 bits (359), Expect = 2e-34
Identities = 78/203 (38%), Positives = 114/203 (56%), Gaps = 3/203 (1%)
Query: 548 VALDYHYEKKLVFWSENNLRVIRVAQMNT-KNMSDVIRWGLETPAGVAVDWIHDLLFWTD 606
V +DY +++V+W++ R I A + ++ GL +P G+A+D I ++WTD
Sbjct: 1146 VGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTD 1205
Query: 607 SGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPN-PKIERADMDGDK 665
S ++E A LDGS+R VL DL PRAIAV P ++WTDW PKIE + +DG+
Sbjct: 1206 SVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGEN 1265
Query: 666 RKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAFDGRDRRKVTTKGLPHPFALTL 725
R+ +I +I PNGLT D + WADA +E DG RR V L +PF++
Sbjct: 1266 RRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRR-VIQNNLKYPFSIVS 1324
Query: 726 FDDAIYWTDWHTKSISTVNKNTG 748
+ D Y TDW + +VNK++G
Sbjct: 1325 YADHFYHTDWRRDGVVSVNKHSG 1347
Score = 62.1 bits (144), Expect = 2e-08
Identities = 39/140 (27%), Positives = 67/140 (47%), Gaps = 4/140 (2%)
Query: 540 VVKGLHNAVALDYHYEKKLVFWSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIH 599
V GL + L + ++ ++W+++ L I A ++ + L P +AVD I
Sbjct: 1182 VNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIR 1241
Query: 600 DLLFWTDSGTR--RVEVATLDGSKRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIE 657
L+WTD ++E ++LDG R +L+ D+ P + P L+ W D G K+E
Sbjct: 1242 GNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAG-TKKLE 1300
Query: 658 RADMDGDKRKTVIYDEIFWP 677
DG R+ VI + + +P
Sbjct: 1301 CTLPDGTGRR-VIQNNLKYP 1319
Score = 57.2 bits (132), Expect = 5e-07
Identities = 37/116 (31%), Positives = 59/116 (50%), Gaps = 8/116 (6%)
Query: 908 VMYWSDWGASPCIERADMD-GGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYA 966
++YW+D A I RA ++ G + ++ + P GLA+D + +YWTD IE A
Sbjct: 1156 MVYWTDV-AGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESA 1214
Query: 967 NLDGTGRTKLIEN---LPHPFGLDLYGDEVFWTDWDTQS--IQAANKDTGAKRRTL 1017
LDG+ R L P +D ++WTDW+ ++ I+ ++ D G RR L
Sbjct: 1215 LLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLD-GENRRIL 1269
Score = 46.4 bits (105), Expect = 0.001
Identities = 23/50 (46%), Positives = 28/50 (56%), Gaps = 3/50 (6%)
Query: 452 ACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGY 501
+CAC G+ A D + C D+DEC E + TC NT GSF C C GY
Sbjct: 877 SCACLPGY--AGDGHQCTDVDECS-ENRCHPAATCYNTPGSFSCRCQPGY 923
Score = 36.7 bits (81), Expect = 0.76
Identities = 20/61 (32%), Positives = 28/61 (45%), Gaps = 7/61 (11%)
Query: 453 CACPMGFLLAEDKYSCRDIDEC---MYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERS 509
C C G+ D +C D +EC + P + C N GS+RC C +GY D +
Sbjct: 787 CECASGY--QGDGRNCVDENECATGFHRCGP--NSVCINLPGSYRCECRSGYEFADDRHT 842
Query: 510 C 510
C
Sbjct: 843 C 843
>BC072015-1|AAH72015.1| 296|Homo sapiens LRP1 protein protein.
Length = 296
Score = 151 bits (367), Expect = 2e-35
Identities = 83/226 (36%), Positives = 113/226 (50%), Gaps = 14/226 (6%)
Query: 344 RNCSLDEYTCADR-RCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAF 402
+ CS ++ C D+ C+ K W CDG RDC +G DE E+ + C+P EH
Sbjct: 25 KTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAP-EICPQSKAQRCQPNEHNCLGT- 82
Query: 403 RNCVNRKHVCDGMKDCPRGDDE-ERC-PLKRKCSAEEKCEKLCITTYDGHAACACPMGFL 460
CV +C+G++DC G DE C L+ CS C+ C+ T DG C C F
Sbjct: 83 ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCS-RLGCQHHCVPTLDG-PTCYCNSSFQ 140
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCK----PTGES 516
L D +C+D DEC CSQ C+NT GSF CGC+ GY+L+PD RSCK P
Sbjct: 141 LQADGKTCKDFDECSVYG--TCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRP 198
Query: 517 PTLLFSNRIGIRQVWLTGDNYMSVV-KGLHNAVALDYHYEKKLVFW 561
P LL +N I +L+G ++ A+D+ Y + V W
Sbjct: 199 PVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCW 244
Score = 94.3 bits (224), Expect = 4e-18
Identities = 63/208 (30%), Positives = 87/208 (41%), Gaps = 15/208 (7%)
Query: 301 PGSCNAGEFKCNDG-KCIPERWRCDNERDCADGGDELN--CKPNSIRNCSLDEYTC-ADR 356
P +C+ +F C D CI + WRCD ERDC DG DE C + + C +E+ C
Sbjct: 24 PKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTE 83
Query: 357 RCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKH--VCDG 414
CV + LC+GV+DC +G DE C E Q C +CV C
Sbjct: 84 LCVPMSRLCNGVQDCMDGSDE---GPHCRELQGNCS-----RLGCQHHCVPTLDGPTCYC 135
Query: 415 MKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
D + C +CS C +LC T DG C C G+LL D SC+ +E
Sbjct: 136 NSSFQLQADGKTCKDFDECSVYGTCSQLCTNT-DGSFICGCVEGYLLQPDNRSCKAKNEP 194
Query: 475 MYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
+ + N + ++ G I
Sbjct: 195 VDRPPVLLIANSQNILATYLSGAQVSTI 222
Score = 56.4 bits (130), Expect = 9e-07
Identities = 27/78 (34%), Positives = 39/78 (50%), Gaps = 5/78 (6%)
Query: 263 CAEIDFECKNT-KCVPKDFQCDGDNDCGDWTDE--DSCPMVPGS-CNAGEFKC-NDGKCI 317
C+ F C++ C+ K ++CDG+ DC D +DE + CP C E C C+
Sbjct: 27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCV 86
Query: 318 PERWRCDNERDCADGGDE 335
P C+ +DC DG DE
Sbjct: 87 PMSRLCNGVQDCMDGSDE 104
Score = 37.1 bits (82), Expect = 0.57
Identities = 18/48 (37%), Positives = 22/48 (45%)
Query: 1009 DTGAKRRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
D G R L + GC H C+ G +C C +L DGKTC D
Sbjct: 103 DEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKD 150
Score = 35.5 bits (78), Expect = 1.7
Identities = 13/26 (50%), Positives = 15/26 (57%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDE 192
C CI+ W CDG+ DC D SDE
Sbjct: 34 CRDQITCISKGWRCDGERDCPDGSDE 59
>BC052593-1|AAH52593.1| 296|Homo sapiens LRP1 protein protein.
Length = 296
Score = 151 bits (367), Expect = 2e-35
Identities = 83/226 (36%), Positives = 113/226 (50%), Gaps = 14/226 (6%)
Query: 344 RNCSLDEYTCADR-RCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAF 402
+ CS ++ C D+ C+ K W CDG RDC +G DE E+ + C+P EH
Sbjct: 25 KTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAP-EICPQSKAQRCQPNEHNCLGT- 82
Query: 403 RNCVNRKHVCDGMKDCPRGDDE-ERC-PLKRKCSAEEKCEKLCITTYDGHAACACPMGFL 460
CV +C+G++DC G DE C L+ CS C+ C+ T DG C C F
Sbjct: 83 ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCS-RLGCQHHCVPTLDG-PTCYCNSSFQ 140
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCK----PTGES 516
L D +C+D DEC CSQ C+NT GSF CGC+ GY+L+PD RSCK P
Sbjct: 141 LQADGKTCKDFDECSVYG--TCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRP 198
Query: 517 PTLLFSNRIGIRQVWLTGDNYMSVV-KGLHNAVALDYHYEKKLVFW 561
P LL +N I +L+G ++ A+D+ Y + V W
Sbjct: 199 PVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCW 244
Score = 94.3 bits (224), Expect = 4e-18
Identities = 63/208 (30%), Positives = 87/208 (41%), Gaps = 15/208 (7%)
Query: 301 PGSCNAGEFKCNDG-KCIPERWRCDNERDCADGGDELN--CKPNSIRNCSLDEYTC-ADR 356
P +C+ +F C D CI + WRCD ERDC DG DE C + + C +E+ C
Sbjct: 24 PKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTE 83
Query: 357 RCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKH--VCDG 414
CV + LC+GV+DC +G DE C E Q C +CV C
Sbjct: 84 LCVPMSRLCNGVQDCMDGSDE---GPHCRELQGNCS-----RLGCQHHCVPTLDGPTCYC 135
Query: 415 MKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
D + C +CS C +LC T DG C C G+LL D SC+ +E
Sbjct: 136 NSSFQLQADGKTCKDFDECSVYGTCSQLCTNT-DGSFICGCVEGYLLQPDNRSCKAKNEP 194
Query: 475 MYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
+ + N + ++ G I
Sbjct: 195 VDRPPVLLIANSQNILATYLSGAQVSTI 222
Score = 56.4 bits (130), Expect = 9e-07
Identities = 27/78 (34%), Positives = 39/78 (50%), Gaps = 5/78 (6%)
Query: 263 CAEIDFECKNT-KCVPKDFQCDGDNDCGDWTDE--DSCPMVPGS-CNAGEFKC-NDGKCI 317
C+ F C++ C+ K ++CDG+ DC D +DE + CP C E C C+
Sbjct: 27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCV 86
Query: 318 PERWRCDNERDCADGGDE 335
P C+ +DC DG DE
Sbjct: 87 PMSRLCNGVQDCMDGSDE 104
Score = 37.1 bits (82), Expect = 0.57
Identities = 18/48 (37%), Positives = 22/48 (45%)
Query: 1009 DTGAKRRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
D G R L + GC H C+ G +C C +L DGKTC D
Sbjct: 103 DEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKD 150
Score = 35.5 bits (78), Expect = 1.7
Identities = 13/26 (50%), Positives = 15/26 (57%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDE 192
C CI+ W CDG+ DC D SDE
Sbjct: 34 CRDQITCISKGWRCDGERDCPDGSDE 59
>BC045107-1|AAH45107.1| 292|Homo sapiens LRP1 protein protein.
Length = 292
Score = 151 bits (367), Expect = 2e-35
Identities = 83/226 (36%), Positives = 113/226 (50%), Gaps = 14/226 (6%)
Query: 344 RNCSLDEYTCADR-RCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAF 402
+ CS ++ C D+ C+ K W CDG RDC +G DE E+ + C+P EH
Sbjct: 25 KTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAP-EICPQSKAQRCQPNEHNCLGT- 82
Query: 403 RNCVNRKHVCDGMKDCPRGDDE-ERC-PLKRKCSAEEKCEKLCITTYDGHAACACPMGFL 460
CV +C+G++DC G DE C L+ CS C+ C+ T DG C C F
Sbjct: 83 ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCS-RLGCQHHCVPTLDG-PTCYCNSSFQ 140
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCK----PTGES 516
L D +C+D DEC CSQ C+NT GSF CGC+ GY+L+PD RSCK P
Sbjct: 141 LQADGKTCKDFDECSVYG--TCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRP 198
Query: 517 PTLLFSNRIGIRQVWLTGDNYMSVV-KGLHNAVALDYHYEKKLVFW 561
P LL +N I +L+G ++ A+D+ Y + V W
Sbjct: 199 PVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCW 244
Score = 94.3 bits (224), Expect = 4e-18
Identities = 63/208 (30%), Positives = 87/208 (41%), Gaps = 15/208 (7%)
Query: 301 PGSCNAGEFKCNDG-KCIPERWRCDNERDCADGGDELN--CKPNSIRNCSLDEYTC-ADR 356
P +C+ +F C D CI + WRCD ERDC DG DE C + + C +E+ C
Sbjct: 24 PKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTE 83
Query: 357 RCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKH--VCDG 414
CV + LC+GV+DC +G DE C E Q C +CV C
Sbjct: 84 LCVPMSRLCNGVQDCMDGSDE---GPHCRELQGNCS-----RLGCQHHCVPTLDGPTCYC 135
Query: 415 MKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
D + C +CS C +LC T DG C C G+LL D SC+ +E
Sbjct: 136 NSSFQLQADGKTCKDFDECSVYGTCSQLCTNT-DGSFICGCVEGYLLQPDNRSCKAKNEP 194
Query: 475 MYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
+ + N + ++ G I
Sbjct: 195 VDRPPVLLIANSQNILATYLSGAQVSTI 222
Score = 56.4 bits (130), Expect = 9e-07
Identities = 27/78 (34%), Positives = 39/78 (50%), Gaps = 5/78 (6%)
Query: 263 CAEIDFECKNT-KCVPKDFQCDGDNDCGDWTDE--DSCPMVPGS-CNAGEFKC-NDGKCI 317
C+ F C++ C+ K ++CDG+ DC D +DE + CP C E C C+
Sbjct: 27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCV 86
Query: 318 PERWRCDNERDCADGGDE 335
P C+ +DC DG DE
Sbjct: 87 PMSRLCNGVQDCMDGSDE 104
Score = 37.1 bits (82), Expect = 0.57
Identities = 18/48 (37%), Positives = 22/48 (45%)
Query: 1009 DTGAKRRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
D G R L + GC H C+ G +C C +L DGKTC D
Sbjct: 103 DEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKD 150
Score = 35.5 bits (78), Expect = 1.7
Identities = 13/26 (50%), Positives = 15/26 (57%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDE 192
C CI+ W CDG+ DC D SDE
Sbjct: 34 CRDQITCISKGWRCDGERDCPDGSDE 59
>AL450467-1|CAH72452.1| 173|Homo sapiens very low density
lipoprotein receptor protein.
Length = 173
Score = 133 bits (321), Expect = 6e-30
Identities = 54/133 (40%), Positives = 83/133 (62%), Gaps = 8/133 (6%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
+C F+C N +C+ ++CDGD DC D +DE +C V +C +F CN+G+C+P RW
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC--VKKTCAESDFVCNNGQCVPSRW 89
Query: 322 RCDNERDCADGGDELNCKPNSIRN--CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMN 379
+CD + DC DG DE P RN CS DE+TC+ RC+ + ++C+G DC++G DE++
Sbjct: 90 KCDGDPDCEDGSDE---SPEQCRNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELD 146
Query: 380 C-EVSCEEDQYTC 391
C +C ++ C
Sbjct: 147 CAPPTCGAHEFQC 159
Score = 106 bits (255), Expect = 6e-22
Identities = 50/134 (37%), Positives = 67/134 (50%), Gaps = 10/134 (7%)
Query: 304 CNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTW 363
C +F+C +G+CI W+CD + DC DG DE NC + C+ ++ C + +CV W
Sbjct: 33 CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVK---KTCAESDFVCNNGQCVPSRW 89
Query: 364 LCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDD 423
CDG DC +G DE C TC P E S+ C++R VC+G DC G D
Sbjct: 90 KCDGDPDCEDGSDES--PEQCRN--ITCSPDEFTCSSG--RCISRNFVCNGQDDCSDGSD 143
Query: 424 EERCPLKRKCSAEE 437
E C C A E
Sbjct: 144 ELDC-APPTCGAHE 156
Score = 105 bits (253), Expect = 1e-21
Identities = 43/104 (41%), Positives = 62/104 (59%), Gaps = 3/104 (2%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
CAE DF C N +CVP ++CDGD DC D +DE +C+ EF C+ G+CI +
Sbjct: 72 CAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCRNITCSPDEFTCSSGRCISRNFV 131
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCD 366
C+ + DC+DG DEL+C P + C E+ C+ C+ +W+CD
Sbjct: 132 CNGQDDCSDGSDELDCAPPT---CGAHEFQCSTSSCIPISWVCD 172
Score = 68.1 bits (159), Expect = 3e-10
Identities = 25/63 (39%), Positives = 39/63 (61%), Gaps = 2/63 (3%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C+ +F C + +C+ ++F C+G +DC D +DE C P +C A EF+C+ CIP W
Sbjct: 113 CSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDC--APPTCGAHEFQCSTSSCIPISWV 170
Query: 323 CDN 325
CD+
Sbjct: 171 CDD 173
Score = 35.5 bits (78), Expect = 1.7
Identities = 12/27 (44%), Positives = 20/27 (74%)
Query: 169 STNVCIALEWLCDGDNDCGDFSDEINC 195
S+ CI+ ++C+G +DC D SDE++C
Sbjct: 121 SSGRCISRNFVCNGQDDCSDGSDELDC 147
Score = 35.1 bits (77), Expect = 2.3
Identities = 14/31 (45%), Positives = 19/31 (61%), Gaps = 1/31 (3%)
Query: 162 ENRTICHSTNVCIALEWLCDGDNDCGDFSDE 192
E+ +C++ C+ W CDGD DC D SDE
Sbjct: 74 ESDFVCNNGQ-CVPSRWKCDGDPDCEDGSDE 103
>AF117899-1|AAF27280.1| 363|Homo sapiens LDLR-FUT fusion protein
protein.
Length = 363
Score = 130 bits (315), Expect = 3e-29
Identities = 60/170 (35%), Positives = 91/170 (53%), Gaps = 15/170 (8%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND--GKCIPE 319
RC +F+C++ KC+ + CDG +C D +DE + +C +G+F C +CIP+
Sbjct: 26 RCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQ 85
Query: 320 RWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMN 379
WRCD + DC +G DE C P + CS DE+ C D +C+ + ++CD RDC +G DE +
Sbjct: 86 FWRCDGQVDCDNGSDEQGCPP---KTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEAS 142
Query: 380 CEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDE--ERC 427
C V C P +++ C+ + CD DC G DE +RC
Sbjct: 143 CPV------LICGPASFQCNSS--TCIPQLWACDNDPDCEDGSDEWPQRC 184
Score = 125 bits (302), Expect = 1e-27
Identities = 62/172 (36%), Positives = 88/172 (51%), Gaps = 15/172 (8%)
Query: 263 CAEIDFEC--KNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPER 320
C DF C + +C+P+ ++CDG DC + +DE CP P +C+ EF+C+DGKCI +
Sbjct: 68 CKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCP--PKTCSQDEFRCHDGKCISRQ 125
Query: 321 WRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDE--M 378
+ CD++RDC DG DE +C + C + C C+ + W CD DC +G DE
Sbjct: 126 FVCDSDRDCLDGSDEASC---PVLICGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQ 182
Query: 379 NCE--VSCEEDQYTCRPQE-HLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC 427
C + D C E H +S C++ CDG DC DEE C
Sbjct: 183 RCRGLYVFQGDSSPCSAFEFHCLSG---ECIHSSWRCDGGPDCKDKSDEENC 231
Score = 123 bits (297), Expect = 5e-27
Identities = 68/215 (31%), Positives = 99/215 (46%), Gaps = 29/215 (13%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
CI+ +W+CDG +C D SDE +T L V + + G + +
Sbjct: 39 CISYKWVCDGSAECQDGSDESQ----ETCLSVTCKSGDFSCGGRVNR-----------CI 83
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWT 292
++ + DN ++ Q C++ +F C + KC+ + F CD D DC D +
Sbjct: 84 PQFWRCDGQVDCDNGSD-----EQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGS 138
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDE--LNCK-----PNSIRN 345
DE SCP++ C F+CN CIP+ W CDN+ DC DG DE C+
Sbjct: 139 DEASCPVL--ICGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSP 196
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC 380
CS E+ C C+ +W CDG DC + DE NC
Sbjct: 197 CSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENC 231
Score = 107 bits (258), Expect = 3e-22
Identities = 49/129 (37%), Positives = 68/129 (52%), Gaps = 13/129 (10%)
Query: 304 CNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADR--RCVLK 361
C EF+C DGKCI +W CD +C DG DE S+ C +++C R RC+ +
Sbjct: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSV-TCKSGDFSCGGRVNRCIPQ 85
Query: 362 TWLCDGVRDCTNGEDEMNC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPR 420
W CDG DC NG DE C +C +D++ C + C++R+ VCD +DC
Sbjct: 86 FWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGK---------CISRQFVCDSDRDCLD 136
Query: 421 GDDEERCPL 429
G DE CP+
Sbjct: 137 GSDEASCPV 145
Score = 73.3 bits (172), Expect = 7e-12
Identities = 37/98 (37%), Positives = 47/98 (47%), Gaps = 8/98 (8%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDE--DSCPMV------PGSCNAGEFKCNDG 314
C F+C ++ C+P+ + CD D DC D +DE C + C+A EF C G
Sbjct: 148 CGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSG 207
Query: 315 KCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYT 352
+CI WRCD DC D DE NC S S E T
Sbjct: 208 ECIHSSWRCDGGPDCKDKSDEENCGGRSTVRFSWPERT 245
Score = 69.3 bits (162), Expect = 1e-10
Identities = 39/125 (31%), Positives = 58/125 (46%), Gaps = 10/125 (8%)
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNC 405
C +E+ C D +C+ W+CDG +C +G DE + +C TC+ + C
Sbjct: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDES--QETCLS--VTCKSGDFSCGGRVNRC 82
Query: 406 VNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE-KC-EKLCITTYDGHAACACPMGFLLAE 463
+ + CDG DC G DE+ CP K CS +E +C + CI+ C L
Sbjct: 83 IPQFWRCDGQVDCDNGSDEQGCPPK-TCSQDEFRCHDGKCISR---QFVCDSDRDCLDGS 138
Query: 464 DKYSC 468
D+ SC
Sbjct: 139 DEASC 143
Score = 56.8 bits (131), Expect = 7e-07
Identities = 39/142 (27%), Positives = 64/142 (45%), Gaps = 17/142 (11%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
++C + E R CH CI+ +++CD D DC D SDE +C V L+ A+ N
Sbjct: 107 KTCSQDEFR--CHDGK-CISRQFVCDSDRDCLDGSDEASCPV----LICGPASFQCNSST 159
Query: 216 VITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKC 275
I P + P C + + R + + C+ +F C + +C
Sbjct: 160 CI--PQLWACDNDPD--------CEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGEC 209
Query: 276 VPKDFQCDGDNDCGDWTDEDSC 297
+ ++CDG DC D +DE++C
Sbjct: 210 IHSSWRCDGGPDCKDKSDEENC 231
>X62515-1|CAA44373.1| 4393|Homo sapiens Human basement membrane
heparan sulfate proteoglycan core protein protein.
Length = 4393
Score = 127 bits (306), Expect = 4e-28
Identities = 73/229 (31%), Positives = 107/229 (46%), Gaps = 26/229 (11%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
R+C E E CHS N C+ALE+ CD DC D SDE+NC+ + P+ + +
Sbjct: 197 RACTEAE--FACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGIS-PTFSLLVETTS 253
Query: 216 VITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKC 275
+ P I + +P V + + L + P + C + C+N C
Sbjct: 254 LPPRPETTI-MRQPPV-----THAPQPLLPGSVRP----------LPCGPQEAACRNGHC 297
Query: 276 VPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDE 335
+P+D+ CDG DC D +DE C P C EF C +G C + WRCD + DC D DE
Sbjct: 298 IPRDYLCDGQEDCEDGSDELDCG-PPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDE 356
Query: 336 LNC---KPNSIRNCSLDEYTC-ADRRCVLKTWLCDGVRDCTNGEDEMNC 380
NC +P + C ++ C + C+ ++ CD DC + DE C
Sbjct: 357 ANCPTKRPEEV--CGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 100 bits (239), Expect = 5e-20
Identities = 50/135 (37%), Positives = 64/135 (47%), Gaps = 10/135 (7%)
Query: 298 PMVPGS-----CNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYT 352
P++PGS C E C +G CIP + CD + DC DG DEL+C P C +E+
Sbjct: 274 PLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPPP--PCEPNEFP 331
Query: 353 CADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVC 412
C + C LK W CDG DC + DE NC E+ C P + + C+ C
Sbjct: 332 CGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEE--VCGPTQFRCVST-NMCIPASFHC 388
Query: 413 DGMKDCPRGDDEERC 427
D DCP DE C
Sbjct: 389 DEESDCPDRSDEFGC 403
Score = 75.4 bits (177), Expect = 2e-12
Identities = 34/84 (40%), Positives = 43/84 (51%), Gaps = 3/84 (3%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGS--CNAGEFKC-NDGKCIPE 319
C +F C N C K ++CDGD DC D TDE +CP C +F+C + CIP
Sbjct: 325 CEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPA 384
Query: 320 RWRCDNERDCADGGDELNCKPNSI 343
+ CD E DC D DE C P +
Sbjct: 385 SFHCDEESDCPDRSDEFGCMPPQV 408
Score = 41.1 bits (92), Expect = 0.035
Identities = 39/133 (29%), Positives = 53/133 (39%), Gaps = 23/133 (17%)
Query: 391 CRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGH 450
C PQE N +C+ R ++CDG +DC G DE C CE +GH
Sbjct: 285 CGPQEAACRNG--HCIPRDYLCDGQEDCEDGSDE------LDCGPPPPCEPNEFPCGNGH 336
Query: 451 AACACPMGFLLAEDKYSCRD-IDE--CMYEQ-DPVCSQT---CSNT----VGSFRCGCMT 499
C + + + C D DE C ++ + VC T C +T SF C +
Sbjct: 337 ----CALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEES 392
Query: 500 GYILRPDERSCKP 512
R DE C P
Sbjct: 393 DCPDRSDEFGCMP 405
Score = 35.1 bits (77), Expect = 2.3
Identities = 17/47 (36%), Positives = 22/47 (46%), Gaps = 1/47 (2%)
Query: 336 LNCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCE 381
L P R C+ E+ C CV + CD DC + DE+NCE
Sbjct: 189 LGTVPQFPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCE 235
>M85289-1|AAA52700.1| 4391|Homo sapiens heparan sulfate proteoglycan
protein.
Length = 4391
Score = 127 bits (306), Expect = 4e-28
Identities = 73/229 (31%), Positives = 107/229 (46%), Gaps = 26/229 (11%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
R+C E E CHS N C+ALE+ CD DC D SDE+NC+ + P+ + +
Sbjct: 197 RACTEAE--FACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGIS-PTFSLLVETTS 253
Query: 216 VITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKC 275
+ P I + +P V + + L + P + C + C+N C
Sbjct: 254 LPPRPETTI-MRQPPV-----THAPQPLLPGSVRP----------LPCGPQEAACRNGHC 297
Query: 276 VPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDE 335
+P+D+ CDG DC D +DE C P C EF C +G C + WRCD + DC D DE
Sbjct: 298 IPRDYLCDGQEDCEDGSDELDCG-PPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDE 356
Query: 336 LNC---KPNSIRNCSLDEYTC-ADRRCVLKTWLCDGVRDCTNGEDEMNC 380
NC +P + C ++ C + C+ ++ CD DC + DE C
Sbjct: 357 ANCPTKRPEEV--CGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 100 bits (239), Expect = 5e-20
Identities = 50/135 (37%), Positives = 64/135 (47%), Gaps = 10/135 (7%)
Query: 298 PMVPGS-----CNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYT 352
P++PGS C E C +G CIP + CD + DC DG DEL+C P C +E+
Sbjct: 274 PLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPPP--PCEPNEFP 331
Query: 353 CADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVC 412
C + C LK W CDG DC + DE NC E+ C P + + C+ C
Sbjct: 332 CGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEE--VCGPTQFRCVST-NMCIPASFHC 388
Query: 413 DGMKDCPRGDDEERC 427
D DCP DE C
Sbjct: 389 DEESDCPDRSDEFGC 403
Score = 75.4 bits (177), Expect = 2e-12
Identities = 34/84 (40%), Positives = 43/84 (51%), Gaps = 3/84 (3%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGS--CNAGEFKC-NDGKCIPE 319
C +F C N C K ++CDGD DC D TDE +CP C +F+C + CIP
Sbjct: 325 CEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPA 384
Query: 320 RWRCDNERDCADGGDELNCKPNSI 343
+ CD E DC D DE C P +
Sbjct: 385 SFHCDEESDCPDRSDEFGCMPPQV 408
Score = 41.1 bits (92), Expect = 0.035
Identities = 39/133 (29%), Positives = 53/133 (39%), Gaps = 23/133 (17%)
Query: 391 CRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGH 450
C PQE N +C+ R ++CDG +DC G DE C CE +GH
Sbjct: 285 CGPQEAACRNG--HCIPRDYLCDGQEDCEDGSDE------LDCGPPPPCEPNEFPCGNGH 336
Query: 451 AACACPMGFLLAEDKYSCRD-IDE--CMYEQ-DPVCSQT---CSNT----VGSFRCGCMT 499
C + + + C D DE C ++ + VC T C +T SF C +
Sbjct: 337 ----CALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEES 392
Query: 500 GYILRPDERSCKP 512
R DE C P
Sbjct: 393 DCPDRSDEFGCMP 405
Score = 35.1 bits (77), Expect = 2.3
Identities = 17/47 (36%), Positives = 22/47 (46%), Gaps = 1/47 (2%)
Query: 336 LNCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCE 381
L P R C+ E+ C CV + CD DC + DE+NCE
Sbjct: 189 LGTVPQFPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCE 235
>AL590556-2|CAH71870.1| 4391|Homo sapiens heparan sulfate
proteoglycan 2 (perlecan) protein.
Length = 4391
Score = 127 bits (306), Expect = 4e-28
Identities = 73/229 (31%), Positives = 107/229 (46%), Gaps = 26/229 (11%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
R+C E E CHS N C+ALE+ CD DC D SDE+NC+ + P+ + +
Sbjct: 197 RACTEAE--FACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGIS-PTFSLLVETTS 253
Query: 216 VITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKC 275
+ P I + +P V + + L + P + C + C+N C
Sbjct: 254 LPPRPETTI-MRQPPV-----THAPQPLLPGSVRP----------LPCGPQEAACRNGHC 297
Query: 276 VPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDE 335
+P+D+ CDG DC D +DE C P C EF C +G C + WRCD + DC D DE
Sbjct: 298 IPRDYLCDGQEDCEDGSDELDCG-PPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDE 356
Query: 336 LNC---KPNSIRNCSLDEYTC-ADRRCVLKTWLCDGVRDCTNGEDEMNC 380
NC +P + C ++ C + C+ ++ CD DC + DE C
Sbjct: 357 ANCPTKRPEEV--CGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 100 bits (239), Expect = 5e-20
Identities = 50/135 (37%), Positives = 64/135 (47%), Gaps = 10/135 (7%)
Query: 298 PMVPGS-----CNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYT 352
P++PGS C E C +G CIP + CD + DC DG DEL+C P C +E+
Sbjct: 274 PLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPPP--PCEPNEFP 331
Query: 353 CADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVC 412
C + C LK W CDG DC + DE NC E+ C P + + C+ C
Sbjct: 332 CGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEE--VCGPTQFRCVST-NMCIPASFHC 388
Query: 413 DGMKDCPRGDDEERC 427
D DCP DE C
Sbjct: 389 DEESDCPDRSDEFGC 403
Score = 75.4 bits (177), Expect = 2e-12
Identities = 34/84 (40%), Positives = 43/84 (51%), Gaps = 3/84 (3%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGS--CNAGEFKC-NDGKCIPE 319
C +F C N C K ++CDGD DC D TDE +CP C +F+C + CIP
Sbjct: 325 CEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPA 384
Query: 320 RWRCDNERDCADGGDELNCKPNSI 343
+ CD E DC D DE C P +
Sbjct: 385 SFHCDEESDCPDRSDEFGCMPPQV 408
Score = 41.1 bits (92), Expect = 0.035
Identities = 39/133 (29%), Positives = 53/133 (39%), Gaps = 23/133 (17%)
Query: 391 CRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGH 450
C PQE N +C+ R ++CDG +DC G DE C CE +GH
Sbjct: 285 CGPQEAACRNG--HCIPRDYLCDGQEDCEDGSDE------LDCGPPPPCEPNEFPCGNGH 336
Query: 451 AACACPMGFLLAEDKYSCRD-IDE--CMYEQ-DPVCSQT---CSNT----VGSFRCGCMT 499
C + + + C D DE C ++ + VC T C +T SF C +
Sbjct: 337 ----CALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEES 392
Query: 500 GYILRPDERSCKP 512
R DE C P
Sbjct: 393 DCPDRSDEFGCMP 405
Score = 35.1 bits (77), Expect = 2.3
Identities = 17/47 (36%), Positives = 22/47 (46%), Gaps = 1/47 (2%)
Query: 336 LNCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCE 381
L P R C+ E+ C CV + CD DC + DE+NCE
Sbjct: 189 LGTVPQFPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCE 235
>AL590103-2|CAI12125.1| 4391|Homo sapiens heparan sulfate
proteoglycan 2 (perlecan) protein.
Length = 4391
Score = 127 bits (306), Expect = 4e-28
Identities = 73/229 (31%), Positives = 107/229 (46%), Gaps = 26/229 (11%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
R+C E E CHS N C+ALE+ CD DC D SDE+NC+ + P+ + +
Sbjct: 197 RACTEAE--FACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGIS-PTFSLLVETTS 253
Query: 216 VITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKC 275
+ P I + +P V + + L + P + C + C+N C
Sbjct: 254 LPPRPETTI-MRQPPV-----THAPQPLLPGSVRP----------LPCGPQEAACRNGHC 297
Query: 276 VPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDE 335
+P+D+ CDG DC D +DE C P C EF C +G C + WRCD + DC D DE
Sbjct: 298 IPRDYLCDGQEDCEDGSDELDCG-PPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDE 356
Query: 336 LNC---KPNSIRNCSLDEYTC-ADRRCVLKTWLCDGVRDCTNGEDEMNC 380
NC +P + C ++ C + C+ ++ CD DC + DE C
Sbjct: 357 ANCPTKRPEEV--CGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 100 bits (239), Expect = 5e-20
Identities = 50/135 (37%), Positives = 64/135 (47%), Gaps = 10/135 (7%)
Query: 298 PMVPGS-----CNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYT 352
P++PGS C E C +G CIP + CD + DC DG DEL+C P C +E+
Sbjct: 274 PLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPPP--PCEPNEFP 331
Query: 353 CADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVC 412
C + C LK W CDG DC + DE NC E+ C P + + C+ C
Sbjct: 332 CGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEE--VCGPTQFRCVST-NMCIPASFHC 388
Query: 413 DGMKDCPRGDDEERC 427
D DCP DE C
Sbjct: 389 DEESDCPDRSDEFGC 403
Score = 75.4 bits (177), Expect = 2e-12
Identities = 34/84 (40%), Positives = 43/84 (51%), Gaps = 3/84 (3%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGS--CNAGEFKC-NDGKCIPE 319
C +F C N C K ++CDGD DC D TDE +CP C +F+C + CIP
Sbjct: 325 CEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPA 384
Query: 320 RWRCDNERDCADGGDELNCKPNSI 343
+ CD E DC D DE C P +
Sbjct: 385 SFHCDEESDCPDRSDEFGCMPPQV 408
Score = 41.1 bits (92), Expect = 0.035
Identities = 39/133 (29%), Positives = 53/133 (39%), Gaps = 23/133 (17%)
Query: 391 CRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGH 450
C PQE N +C+ R ++CDG +DC G DE C CE +GH
Sbjct: 285 CGPQEAACRNG--HCIPRDYLCDGQEDCEDGSDE------LDCGPPPPCEPNEFPCGNGH 336
Query: 451 AACACPMGFLLAEDKYSCRD-IDE--CMYEQ-DPVCSQT---CSNT----VGSFRCGCMT 499
C + + + C D DE C ++ + VC T C +T SF C +
Sbjct: 337 ----CALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEES 392
Query: 500 GYILRPDERSCKP 512
R DE C P
Sbjct: 393 DCPDRSDEFGCMP 405
Score = 35.1 bits (77), Expect = 2.3
Identities = 17/47 (36%), Positives = 22/47 (46%), Gaps = 1/47 (2%)
Query: 336 LNCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCE 381
L P R C+ E+ C CV + CD DC + DE+NCE
Sbjct: 189 LGTVPQFPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCE 235
>AL445795-1|CAC18534.1| 4370|Homo sapiens heparan sulfate
proteoglycan perlecan protein.
Length = 4370
Score = 127 bits (306), Expect = 4e-28
Identities = 73/229 (31%), Positives = 107/229 (46%), Gaps = 26/229 (11%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
R+C E E CHS N C+ALE+ CD DC D SDE+NC+ + P+ + +
Sbjct: 176 RACTEAE--FACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGIS-PTFSLLVETTS 232
Query: 216 VITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKC 275
+ P I + +P V + + L + P + C + C+N C
Sbjct: 233 LPPRPETTI-MRQPPV-----THAPQPLLPGSVRP----------LPCGPQEAACRNGHC 276
Query: 276 VPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDE 335
+P+D+ CDG DC D +DE C P C EF C +G C + WRCD + DC D DE
Sbjct: 277 IPRDYLCDGQEDCEDGSDELDCG-PPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDE 335
Query: 336 LNC---KPNSIRNCSLDEYTC-ADRRCVLKTWLCDGVRDCTNGEDEMNC 380
NC +P + C ++ C + C+ ++ CD DC + DE C
Sbjct: 336 ANCPTKRPEEV--CGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGC 382
Score = 100 bits (239), Expect = 5e-20
Identities = 50/135 (37%), Positives = 64/135 (47%), Gaps = 10/135 (7%)
Query: 298 PMVPGS-----CNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYT 352
P++PGS C E C +G CIP + CD + DC DG DEL+C P C +E+
Sbjct: 253 PLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPPP--PCEPNEFP 310
Query: 353 CADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVC 412
C + C LK W CDG DC + DE NC E+ C P + + C+ C
Sbjct: 311 CGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEE--VCGPTQFRCVST-NMCIPASFHC 367
Query: 413 DGMKDCPRGDDEERC 427
D DCP DE C
Sbjct: 368 DEESDCPDRSDEFGC 382
Score = 75.4 bits (177), Expect = 2e-12
Identities = 34/84 (40%), Positives = 43/84 (51%), Gaps = 3/84 (3%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGS--CNAGEFKC-NDGKCIPE 319
C +F C N C K ++CDGD DC D TDE +CP C +F+C + CIP
Sbjct: 304 CEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPA 363
Query: 320 RWRCDNERDCADGGDELNCKPNSI 343
+ CD E DC D DE C P +
Sbjct: 364 SFHCDEESDCPDRSDEFGCMPPQV 387
Score = 41.1 bits (92), Expect = 0.035
Identities = 39/133 (29%), Positives = 53/133 (39%), Gaps = 23/133 (17%)
Query: 391 CRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGH 450
C PQE N +C+ R ++CDG +DC G DE C CE +GH
Sbjct: 264 CGPQEAACRNG--HCIPRDYLCDGQEDCEDGSDE------LDCGPPPPCEPNEFPCGNGH 315
Query: 451 AACACPMGFLLAEDKYSCRD-IDE--CMYEQ-DPVCSQT---CSNT----VGSFRCGCMT 499
C + + + C D DE C ++ + VC T C +T SF C +
Sbjct: 316 ----CALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEES 371
Query: 500 GYILRPDERSCKP 512
R DE C P
Sbjct: 372 DCPDRSDEFGCMP 384
Score = 35.1 bits (77), Expect = 2.3
Identities = 17/47 (36%), Positives = 22/47 (46%), Gaps = 1/47 (2%)
Query: 336 LNCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCE 381
L P R C+ E+ C CV + CD DC + DE+NCE
Sbjct: 168 LGTVPQFPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCE 214
>AC108036-1|AAX93208.1| 449|Homo sapiens unknown protein.
Length = 449
Score = 127 bits (306), Expect = 4e-28
Identities = 65/165 (39%), Positives = 85/165 (51%), Gaps = 14/165 (8%)
Query: 270 CKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDC 329
C N +C+P CDG+NDCGD +DE C + +C EF+C DG CIP RC+ DC
Sbjct: 292 CYNRRCIPHGKLCDGENDCGDNSDELDCKV--STCATVEFRCADGTCIPRSARCNQNIDC 349
Query: 330 ADGGDELNCKPNSIRNC-SLDEYTCADRRC------VLKTWLCDGVRDCTNGEDEMNCEV 382
AD DE NC + L T RC VL TW+CDG DC + DE+ C V
Sbjct: 350 ADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPV 409
Query: 383 SCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC 427
++++ C +E+ S C+ +CDG KDC G DE C
Sbjct: 410 ---QNKHKC--EENYFSCPSGRCILNTWICDGQKDCEDGRDEFHC 449
Score = 125 bits (301), Expect = 2e-27
Identities = 70/222 (31%), Positives = 117/222 (52%), Gaps = 12/222 (5%)
Query: 1447 GLGVDWIANNIYWTDNE-----HKVIEVARLDGSSRKVLITGLTE--PRALALFPAKGYL 1499
GL + +YWT + ++ R R+ +IT + P LAL + +
Sbjct: 6 GLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLM 65
Query: 1500 YWSDWGE-HPYIERSYLDGSQRQIIVQVDLGFPNGLTIDYKERRLYWTDALKDRIDTSDL 1558
+W++W E HP I RS L G Q++V D+ PNGLTIDY+ +LY++D +I+ +
Sbjct: 66 FWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEY 125
Query: 1559 NGQHRVQLVPDAKNPF-GMTQFKDYIYWTDWYKKSIIRADKRTGKNITLIRTNL-EMAME 1616
+G R +V F + + +YI+W+DW +++I+R++K TG + ++R+++ M
Sbjct: 126 DGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQPMG 185
Query: 1617 IKAVSADRQH-GWNPCKESNGGCSHLCLFRGHEYI-CACPDD 1656
I AV+ D +PC NGGC LCL + + C+C D
Sbjct: 186 IIAVANDTNSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGD 227
Score = 116 bits (279), Expect = 8e-25
Identities = 59/173 (34%), Positives = 82/173 (47%), Gaps = 5/173 (2%)
Query: 267 DFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNE 326
+FEC N +C+ CDG C D +DE SC G C + +CIP CD E
Sbjct: 248 EFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGE 307
Query: 327 RDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC-EVSCE 385
DC D DEL+CK + C+ E+ CAD C+ ++ C+ DC + DE NC C
Sbjct: 308 NDCGDNSDELDCK---VSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCT 364
Query: 386 E-DQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE 437
+ + + N+ CV +CDG DC DE +CP++ K EE
Sbjct: 365 HFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEE 417
Score = 109 bits (263), Expect = 7e-23
Identities = 64/199 (32%), Positives = 103/199 (51%), Gaps = 13/199 (6%)
Query: 592 GVAVDWIHDLLFWTDSGTRRVEVATLDGSK------RAVLVANDLDKPRAIAVHPGDALV 645
G+A D L+WT S T + T+D ++ AV+ ++ D P +A+ L+
Sbjct: 6 GLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLM 65
Query: 646 FWTDWGP-NPKIERADMDGDKRKTVIYDEIFWPNGLTIDYTESKIYWADAKHHVIERAAF 704
FWT+W +P I R+ + G + V+ +I PNGLTIDY K+Y++D IER +
Sbjct: 66 FWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEY 125
Query: 705 DGRDRRKVTTKGLPHPFALTLFDDAIYWTDWHTKSISTVNKNTGMGIQTVHAGL-NVPMD 763
DG R + G +L ++D+ I+W+DW ++I NK TG + + + + + PM
Sbjct: 126 DGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQPMG 185
Query: 764 I-----HSRSCEETPEKLL 777
I + SCE +P LL
Sbjct: 186 IIAVANDTNSCELSPCALL 204
Score = 107 bits (258), Expect = 3e-22
Identities = 44/126 (34%), Positives = 65/126 (51%), Gaps = 8/126 (6%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVP-------GSCNAGEFKCNDGK 315
CA ++F C + C+P+ +C+ + DC D +DE +C G G +CN
Sbjct: 324 CATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTS 383
Query: 316 -CIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNG 374
C+ W CD DC D DEL C + C + ++C RC+L TW+CDG +DC +G
Sbjct: 384 LCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDG 443
Query: 375 EDEMNC 380
DE +C
Sbjct: 444 RDEFHC 449
Score = 104 bits (250), Expect = 3e-21
Identities = 63/222 (28%), Positives = 107/222 (48%), Gaps = 12/222 (5%)
Query: 1135 TADGIVIDSTGRKIYWTDGGRNSIEVAELDGRN------RKVLVWTGLDSPRAIALHYEY 1188
+ +G+ +YWT +SI +D V+ + D P +AL
Sbjct: 3 SVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQ 62
Query: 1189 GYMFWSDWGTS-AKIERADMDGNNRRVIVDNKIKWPNGLAIDRIEGRLYWNDAKILTIES 1247
MFW++W I R+ + G N +V+V I PNGL ID +LY++D + IE
Sbjct: 63 NLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIER 122
Query: 1248 SDFDGHDRRTVLSNVPYPY-GIVIVGQHIYWTDWKTKALHRADKTNASDPIVIRKNL-EG 1305
++DG R ++ + P + + + +I+W+DW +A+ R++K D ++R ++
Sbjct: 123 CEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQ 182
Query: 1306 LMDIRAIQSE-RVLE-NACGTDNGGCSHLCLRSPLG-YTCAC 1344
M I A+ ++ E + C NGGC LCL +P G C+C
Sbjct: 183 PMGIIAVANDTNSCELSPCALLNGGCHDLCLLTPNGRVNCSC 224
Score = 92.3 bits (219), Expect = 1e-17
Identities = 61/219 (27%), Positives = 100/219 (45%), Gaps = 33/219 (15%)
Query: 856 GLAFDWITDKIYWTDGGTNRIEVSKSDGSM------RTLLAWDHIDKPRDIVVNPEGGVM 909
GLA+ D +YWT T+ I D + ++ D P + ++ +M
Sbjct: 6 GLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLM 65
Query: 910 YWSDWGAS-PCIERADMDGGNRKKLIFGQMTWPNGLALDLVHNRIYWTDGGNKTIEYANL 968
+W++W P I R+ + G N + ++ + PNGL +D ++Y++DG IE
Sbjct: 66 FWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEY 125
Query: 969 DGTGRTKLIENLPHPF-GLDLYGDEVFWTDWDTQSIQAANKDTGAKRRTL---------- 1017
DG+ R ++++ P F L +Y + +FW+DW ++I +NK TG + L
Sbjct: 126 DGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQPMG 185
Query: 1018 --------------GCGKNNGGCSHLCLLKPGGR-SCAC 1041
C NGGC LCLL P GR +C+C
Sbjct: 186 IIAVANDTNSCELSPCALLNGGCHDLCLLTPNGRVNCSC 224
Score = 74.9 bits (176), Expect = 2e-12
Identities = 39/131 (29%), Positives = 70/131 (53%), Gaps = 4/131 (3%)
Query: 1098 VDHSTGLIYWTDTGQR--KIQRATRLGTHVETVIGNGLHTADGIVIDSTGRKIYWTDGGR 1155
+D L++WT+ ++ I R+T G + + V+ + T +G+ ID K+Y++DG
Sbjct: 58 LDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSL 117
Query: 1156 NSIEVAELDGRNRKVLVWTGLDSPRAIALHYEYGYMFWSDWGTSAKIERADMDGNNRRVI 1215
IE E DG R V+V +G + ++A+ Y+ Y+FWSDWG A + G + +++
Sbjct: 118 GKIERCEYDGSQRHVIVKSGPGTFLSLAV-YD-NYIFWSDWGRRAILRSNKYTGGDTKIL 175
Query: 1216 VDNKIKWPNGL 1226
+ P G+
Sbjct: 176 RSDIPHQPMGI 186
Score = 63.3 bits (147), Expect = 8e-09
Identities = 34/119 (28%), Positives = 60/119 (50%), Gaps = 4/119 (3%)
Query: 817 DQKSNSIFWTDVEKD--TINRAYLNGSHQTTIVDSNLIWPAGLAFDWITDKIYWTDGGTN 874
D+ N +FWT+ + +I R+ L G + +V ++++ P GL D+ +K+Y++DG
Sbjct: 59 DECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLG 118
Query: 875 RIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGGVMYWSDWGASPCIERADMDGGNRKKL 933
+IE + DGS R ++ + V ++WSDWG + GG+ K L
Sbjct: 119 KIERCEYDGSQRHVIVKSGPGTFLSLAV--YDNYIFWSDWGRRAILRSNKYTGGDTKIL 175
Score = 57.2 bits (132), Expect = 5e-07
Identities = 28/91 (30%), Positives = 50/91 (54%), Gaps = 3/91 (3%)
Query: 1434 SKTIISQKLETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLI-TGLTEPRALAL 1492
++ ++S + TPNGL +D+ A +Y++D IE DGS R V++ +G +LA+
Sbjct: 87 AQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAV 146
Query: 1493 FPAKGYLYWSDWGEHPYIERSYLDGSQRQII 1523
+ Y++WSDWG + + G +I+
Sbjct: 147 Y--DNYIFWSDWGRRAILRSNKYTGGDTKIL 175
Score = 56.0 bits (129), Expect = 1e-06
Identities = 32/120 (26%), Positives = 60/120 (50%), Gaps = 3/120 (2%)
Query: 561 WSENNLRVIRVAQMNTKNMSDVIRWGLETPAGVAVDWIHDLLFWTDSGTRRVEVATLDGS 620
W+E + ++R + + KN V+ + TP G+ +D+ + L+++D ++E DGS
Sbjct: 70 WNEQHPSIMR-STLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEYDGS 128
Query: 621 KRAVLVANDLDKPRAIAVHPGDALVFWTDWGPNPKIERADMDGDKRKTVIYDEIFWPNGL 680
+R V+V + ++AV+ D +FW+DWG + G K + D P G+
Sbjct: 129 QRHVIVKSGPGTFLSLAVY--DNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQPMGI 186
Score = 55.2 bits (127), Expect = 2e-06
Identities = 18/31 (58%), Positives = 25/31 (80%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCDV 197
C+ST++C+ W+CDG NDCGD+SDE+ C V
Sbjct: 379 CNSTSLCVLPTWICDGSNDCGDYSDELKCPV 409
Score = 48.4 bits (110), Expect = 2e-04
Identities = 48/186 (25%), Positives = 75/186 (40%), Gaps = 21/186 (11%)
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSI--RNCSLDE 350
D +SC + P C C+D + R + C+ GD + + N +N S +
Sbjct: 192 DTNSCELSP--CALLNGGCHDLCLLTPNGRVN----CSCRGDRILLEDNRCVTKNSSCNA 245
Query: 351 YT---CADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVN 407
Y+ C + C+ CDG+ C + DE + CE +CR N R C+
Sbjct: 246 YSEFECGNGECIDYQLTCDGIPHCKDKSDEKL--LYCENR--SCRRGFKPCYN--RRCIP 299
Query: 408 RKHVCDGMKDCPRGDDEERCPLKRKCSAEEKC-EKLCITTYDGHAACACPMGFLLAEDKY 466
+CDG DC DE C + + E +C + CI A C + A D+
Sbjct: 300 HGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPR---SARCNQNIDCADASDEK 356
Query: 467 SCRDID 472
+C + D
Sbjct: 357 NCNNTD 362
Score = 44.0 bits (99), Expect = 0.005
Identities = 35/125 (28%), Positives = 50/125 (40%), Gaps = 11/125 (8%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
CI C+ + DC D SDE NC+ + + G + N T L L PT +
Sbjct: 336 CIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTT--GFIRCNSTSLCVL--PTWI 391
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWT 292
+ C + D P + +C E F C + +C+ + CDG DC D
Sbjct: 392 CDGSNDCGDYS-DELKCPVQNKH------KCEENYFSCPSGRCILNTWICDGQKDCEDGR 444
Query: 293 DEDSC 297
DE C
Sbjct: 445 DEFHC 449
Score = 40.7 bits (91), Expect = 0.046
Identities = 16/25 (64%), Positives = 19/25 (76%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDV 197
CI LCDG+NDCGD SDE++C V
Sbjct: 297 CIPHGKLCDGENDCGDNSDELDCKV 321
Score = 36.7 bits (81), Expect = 0.76
Identities = 16/34 (47%), Positives = 18/34 (52%), Gaps = 1/34 (2%)
Query: 162 ENRTICHSTNVCIALEWLCDGDNDCGDFSDEINC 195
EN C S CI W+CDG DC D DE +C
Sbjct: 417 ENYFSCPSGR-CILNTWICDGQKDCEDGRDEFHC 449
>BC110451-1|AAI10452.1| 1042|Homo sapiens corin, serine peptidase
protein.
Length = 1042
Score = 122 bits (294), Expect = 1e-26
Identities = 65/190 (34%), Positives = 91/190 (47%), Gaps = 23/190 (12%)
Query: 267 DFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNE 326
+F C + C+P QC+G NDC DW+DE C +C+ F C+ GKC+ CD
Sbjct: 274 NFLCASGICIPGKLQCNGYNDCDDWSDEAHC-----NCSENLFHCHTGKCLNYSLVCDGY 328
Query: 327 RDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEE 386
DC D DE NC N E+ C D RC+ W+CDG DC + DE+NC SC
Sbjct: 329 DDCGDLSDEQNCDCN-----PTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNC--SCH- 380
Query: 387 DQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCP-LKRKC-SAEEKC-EKLC 443
+ L+ C+ CDG +DC G DEE C ++ C +++C C
Sbjct: 381 -------SQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPC 433
Query: 444 ITTYDGHAAC 453
+ + G + C
Sbjct: 434 LDSCGGSSLC 443
Score = 113 bits (271), Expect = 7e-24
Identities = 57/149 (38%), Positives = 75/149 (50%), Gaps = 13/149 (8%)
Query: 246 NAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCN 305
N N W+ C+E F C KC+ CDG +DCGD +DE +C P +
Sbjct: 290 NGYNDCDDWSDEAHC-NCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTT-- 346
Query: 306 AGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLC 365
E +C DG+CI W CD + DC D DE+NC S + L E C + +C+ T+ C
Sbjct: 347 --EHRCGDGRCIAMEWVCDGDHDCVDKSDEVNC---SCHSQGLVE--CRNGQCIPSTFQC 399
Query: 366 DGVRDCTNGEDEMNCEV---SCEEDQYTC 391
DG DC +G DE NC V SC+E C
Sbjct: 400 DGDEDCKDGSDEENCSVIQTSCQEGDQRC 428
Score = 84.6 bits (200), Expect = 3e-15
Identities = 51/152 (33%), Positives = 70/152 (46%), Gaps = 25/152 (16%)
Query: 285 DNDCGDWTDEDS----CPMVPG---SCNAGEFKCNDGKCIPERWRCDNERDCADGGDELN 337
D DC + +E+S C M C+ FKC G+C+ RCD + DC D DE N
Sbjct: 554 DTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEEN 613
Query: 338 --CKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQE 395
CK + C ++++C+ T +CDG DC + DE NC C++D+ C
Sbjct: 614 CGCKERDLWECP------SNKQCLKHTVICDGFPDCPDYMDEKNCSF-CQDDELEC---- 662
Query: 396 HLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC 427
A CV+R CDG DC DE C
Sbjct: 663 -----ANHACVSRDLWCDGEADCSDSSDEWDC 689
Score = 82.2 bits (194), Expect = 2e-14
Identities = 48/144 (33%), Positives = 70/144 (48%), Gaps = 13/144 (9%)
Query: 239 CAKKALDNAANPRSTWNQPVELMR-CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSC 297
C++ +N+ N T P E + C+ F+C++ +CV +CDG DC D +DE++C
Sbjct: 557 CSQFPEENSDN--QTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENC 614
Query: 298 PMVPGSCNAGEFKCNDGK-CIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADR 356
G ++C K C+ CD DC D DE NC C DE CA+
Sbjct: 615 ----GCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCS-----FCQDDELECANH 665
Query: 357 RCVLKTWLCDGVRDCTNGEDEMNC 380
CV + CDG DC++ DE +C
Sbjct: 666 ACVSRDLWCDGEADCSDSSDEWDC 689
Score = 75.8 bits (178), Expect = 1e-12
Identities = 70/231 (30%), Positives = 100/231 (43%), Gaps = 46/231 (19%)
Query: 158 CDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVI 217
C EN +C S +CI + C+G NDC D+SDE +C N S N+
Sbjct: 269 CGRGEN-FLCAS-GICIPGKLQCNGYNDCDDWSDEAHC------------NCSENLFHCH 314
Query: 218 TNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVP 277
T + +L V Y+ C + + + T RC +++ C
Sbjct: 315 TGKCLNYSL----VCDGYDD-CGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVC------- 362
Query: 278 KDFQCDGDNDCGDWTDEDSCPMVPGSCNA-GEFKCNDGKCIPERWRCDNERDCADGGDEL 336
DGD+DC D +DE +C SC++ G +C +G+CIP ++CD + DC DG DE
Sbjct: 363 -----DGDHDCVDKSDEVNC-----SCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEE 412
Query: 337 NCKPNSIRNCSLDEYTCADRRCVLKTWL--CDGVRDCTNGEDEMNCEVSCE 385
NC S+ S E D+RC+ L C G C NC CE
Sbjct: 413 NC---SVIQTSCQE---GDQRCLYNPCLDSCGGSSLCDPNNSLNNCS-QCE 456
Score = 60.1 bits (139), Expect = 7e-08
Identities = 31/83 (37%), Positives = 41/83 (49%), Gaps = 6/83 (7%)
Query: 263 CAEID-FEC-KNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPER 320
C E D +EC N +C+ CDG DC D+ DE +C C E +C + C+
Sbjct: 616 CKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSF----CQDDELECANHACVSRD 671
Query: 321 WRCDNERDCADGGDELNCKPNSI 343
CD E DC+D DE +C SI
Sbjct: 672 LWCDGEADCSDSSDEWDCVTLSI 694
Score = 47.2 bits (107), Expect = 5e-04
Identities = 24/79 (30%), Positives = 36/79 (45%), Gaps = 11/79 (13%)
Query: 349 DEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNR 408
+ + CA C+ C+G DC + DE +C +C E+ + C + C+N
Sbjct: 273 ENFLCASGICIPGKLQCNGYNDCDDWSDEAHC--NCSENLFHCHTGK---------CLNY 321
Query: 409 KHVCDGMKDCPRGDDEERC 427
VCDG DC DE+ C
Sbjct: 322 SLVCDGYDDCGDLSDEQNC 340
Score = 46.4 bits (105), Expect = 0.001
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEF 309
C + + EC N CV +D CDG+ DC D +DE C + + N+ F
Sbjct: 655 CQDDELECANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSF 701
Score = 44.0 bits (99), Expect = 0.005
Identities = 19/45 (42%), Positives = 24/45 (53%)
Query: 157 SCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTS 201
+C H + CI + CDGD DC D SDE NC V++TS
Sbjct: 376 NCSCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTS 420
Score = 37.5 bits (83), Expect = 0.43
Identities = 26/91 (28%), Positives = 37/91 (40%), Gaps = 10/91 (10%)
Query: 370 DCTNGEDEMNCEVSC-EEDQYT--CRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEER 426
DC+ +E + +C D+Y C P + CV CDG DC DEE
Sbjct: 556 DCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSG--QCVLASRRCDGQADCDDDSDEEN 613
Query: 427 CPLKRK----CSAEEKCEKLCITTYDGHAAC 453
C K + C + ++C K + DG C
Sbjct: 614 CGCKERDLWECPSNKQCLKHTVIC-DGFPDC 643
Score = 33.9 bits (74), Expect = 5.3
Identities = 13/29 (44%), Positives = 16/29 (55%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINC 195
C S C+ +CDG DC D+ DE NC
Sbjct: 624 CPSNKQCLKHTVICDGFPDCPDYMDEKNC 652
Score = 33.9 bits (74), Expect = 5.3
Identities = 12/40 (30%), Positives = 24/40 (60%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINC 195
++C ++ + + + C++ + CDG+ DC D SDE +C
Sbjct: 650 KNCSFCQDDELECANHACVSRDLWCDGEADCSDSSDEWDC 689
>AF133845-1|AAD31850.1| 1042|Homo sapiens corin protein.
Length = 1042
Score = 122 bits (294), Expect = 1e-26
Identities = 65/190 (34%), Positives = 91/190 (47%), Gaps = 23/190 (12%)
Query: 267 DFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNE 326
+F C + C+P QC+G NDC DW+DE C +C+ F C+ GKC+ CD
Sbjct: 274 NFLCASGICIPGKLQCNGYNDCDDWSDEAHC-----NCSENLFHCHTGKCLNYSLVCDGY 328
Query: 327 RDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEE 386
DC D DE NC N E+ C D RC+ W+CDG DC + DE+NC SC
Sbjct: 329 DDCGDLSDEQNCDCN-----PTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNC--SCH- 380
Query: 387 DQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCP-LKRKC-SAEEKC-EKLC 443
+ L+ C+ CDG +DC G DEE C ++ C +++C C
Sbjct: 381 -------SQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPC 433
Query: 444 ITTYDGHAAC 453
+ + G + C
Sbjct: 434 LDSCGGSSLC 443
Score = 113 bits (271), Expect = 7e-24
Identities = 57/149 (38%), Positives = 75/149 (50%), Gaps = 13/149 (8%)
Query: 246 NAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCN 305
N N W+ C+E F C KC+ CDG +DCGD +DE +C P +
Sbjct: 290 NGYNDCDDWSDEAHC-NCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTT-- 346
Query: 306 AGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLC 365
E +C DG+CI W CD + DC D DE+NC S + L E C + +C+ T+ C
Sbjct: 347 --EHRCGDGRCIAMEWVCDGDHDCVDKSDEVNC---SCHSQGLVE--CRNGQCIPSTFQC 399
Query: 366 DGVRDCTNGEDEMNCEV---SCEEDQYTC 391
DG DC +G DE NC V SC+E C
Sbjct: 400 DGDEDCKDGSDEENCSVIQTSCQEGDQRC 428
Score = 84.6 bits (200), Expect = 3e-15
Identities = 51/152 (33%), Positives = 70/152 (46%), Gaps = 25/152 (16%)
Query: 285 DNDCGDWTDEDS----CPMVPG---SCNAGEFKCNDGKCIPERWRCDNERDCADGGDELN 337
D DC + +E+S C M C+ FKC G+C+ RCD + DC D DE N
Sbjct: 554 DTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEEN 613
Query: 338 --CKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQE 395
CK + C ++++C+ T +CDG DC + DE NC C++D+ C
Sbjct: 614 CGCKERDLWECP------SNKQCLKHTVICDGFPDCPDYMDEKNCSF-CQDDELEC---- 662
Query: 396 HLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC 427
A CV+R CDG DC DE C
Sbjct: 663 -----ANHACVSRDLWCDGEADCSDSSDEWDC 689
Score = 82.2 bits (194), Expect = 2e-14
Identities = 48/144 (33%), Positives = 70/144 (48%), Gaps = 13/144 (9%)
Query: 239 CAKKALDNAANPRSTWNQPVELMR-CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSC 297
C++ +N+ N T P E + C+ F+C++ +CV +CDG DC D +DE++C
Sbjct: 557 CSQFPEENSDN--QTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENC 614
Query: 298 PMVPGSCNAGEFKCNDGK-CIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADR 356
G ++C K C+ CD DC D DE NC C DE CA+
Sbjct: 615 ----GCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCS-----FCQDDELECANH 665
Query: 357 RCVLKTWLCDGVRDCTNGEDEMNC 380
CV + CDG DC++ DE +C
Sbjct: 666 ACVSRDLWCDGEADCSDSSDEWDC 689
Score = 75.8 bits (178), Expect = 1e-12
Identities = 70/231 (30%), Positives = 100/231 (43%), Gaps = 46/231 (19%)
Query: 158 CDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVI 217
C EN +C S +CI + C+G NDC D+SDE +C N S N+
Sbjct: 269 CGRGEN-FLCAS-GICIPGKLQCNGYNDCDDWSDEAHC------------NCSENLFHCH 314
Query: 218 TNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVP 277
T + +L V Y+ C + + + T RC +++ C
Sbjct: 315 TGKCLNYSL----VCDGYDD-CGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVC------- 362
Query: 278 KDFQCDGDNDCGDWTDEDSCPMVPGSCNA-GEFKCNDGKCIPERWRCDNERDCADGGDEL 336
DGD+DC D +DE +C SC++ G +C +G+CIP ++CD + DC DG DE
Sbjct: 363 -----DGDHDCVDKSDEVNC-----SCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEE 412
Query: 337 NCKPNSIRNCSLDEYTCADRRCVLKTWL--CDGVRDCTNGEDEMNCEVSCE 385
NC S+ S E D+RC+ L C G C NC CE
Sbjct: 413 NC---SVIQTSCQE---GDQRCLYNPCLDSCGGSSLCDPNNSLNNCS-QCE 456
Score = 60.1 bits (139), Expect = 7e-08
Identities = 31/83 (37%), Positives = 41/83 (49%), Gaps = 6/83 (7%)
Query: 263 CAEID-FEC-KNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPER 320
C E D +EC N +C+ CDG DC D+ DE +C C E +C + C+
Sbjct: 616 CKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSF----CQDDELECANHACVSRD 671
Query: 321 WRCDNERDCADGGDELNCKPNSI 343
CD E DC+D DE +C SI
Sbjct: 672 LWCDGEADCSDSSDEWDCVTLSI 694
Score = 47.2 bits (107), Expect = 5e-04
Identities = 24/79 (30%), Positives = 36/79 (45%), Gaps = 11/79 (13%)
Query: 349 DEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNR 408
+ + CA C+ C+G DC + DE +C +C E+ + C + C+N
Sbjct: 273 ENFLCASGICIPGKLQCNGYNDCDDWSDEAHC--NCSENLFHCHTGK---------CLNY 321
Query: 409 KHVCDGMKDCPRGDDEERC 427
VCDG DC DE+ C
Sbjct: 322 SLVCDGYDDCGDLSDEQNC 340
Score = 46.4 bits (105), Expect = 0.001
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEF 309
C + + EC N CV +D CDG+ DC D +DE C + + N+ F
Sbjct: 655 CQDDELECANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSF 701
Score = 44.0 bits (99), Expect = 0.005
Identities = 19/45 (42%), Positives = 24/45 (53%)
Query: 157 SCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTS 201
+C H + CI + CDGD DC D SDE NC V++TS
Sbjct: 376 NCSCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTS 420
Score = 37.5 bits (83), Expect = 0.43
Identities = 26/91 (28%), Positives = 37/91 (40%), Gaps = 10/91 (10%)
Query: 370 DCTNGEDEMNCEVSC-EEDQYT--CRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEER 426
DC+ +E + +C D+Y C P + CV CDG DC DEE
Sbjct: 556 DCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSG--QCVLASRRCDGQADCDDDSDEEN 613
Query: 427 CPLKRK----CSAEEKCEKLCITTYDGHAAC 453
C K + C + ++C K + DG C
Sbjct: 614 CGCKERDLWECPSNKQCLKHTVIC-DGFPDC 643
Score = 33.9 bits (74), Expect = 5.3
Identities = 13/29 (44%), Positives = 16/29 (55%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINC 195
C S C+ +CDG DC D+ DE NC
Sbjct: 624 CPSNKQCLKHTVICDGFPDCPDYMDEKNC 652
Score = 33.9 bits (74), Expect = 5.3
Identities = 12/40 (30%), Positives = 24/40 (60%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINC 195
++C ++ + + + C++ + CDG+ DC D SDE +C
Sbjct: 650 KNCSFCQDDELECANHACVSRDLWCDGEADCSDSSDEWDC 689
>AC068287-1|AAY24318.1| 223|Homo sapiens unknown protein.
Length = 223
Score = 114 bits (274), Expect = 3e-24
Identities = 71/214 (33%), Positives = 103/214 (48%), Gaps = 15/214 (7%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCM 498
C+ C T C C GF + ED SC+D DEC CSQTC NT GS+ C C+
Sbjct: 10 CQYKC-TMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYG--TCSQTCRNTHGSYTCSCV 66
Query: 499 TGYILRPDERSCK----PTGESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAV-ALDYH 553
GY+++PD RSCK PT P LL +N I +L G ++ N + LD+
Sbjct: 67 EGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGSKMATLSSVNGNEIHTLDFI 126
Query: 554 YEKKLVFW-----SENNLRVIRVAQMN--TKNMSDVIRWGLETPAGVAVDWIHDLLFWTD 606
Y + ++ W S N L+ I++ + T + I +A+DW+ L++ D
Sbjct: 127 YNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLYFVD 186
Query: 607 SGTRRVEVATLDGSKRAVLVANDLDKPRAIAVHP 640
R+ V +GS L+ +L P+AIAV P
Sbjct: 187 HVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDP 220
Score = 46.4 bits (105), Expect = 0.001
Identities = 41/176 (23%), Positives = 71/176 (40%), Gaps = 5/176 (2%)
Query: 1327 GGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGSITYISLESP 1386
G CS C + YTC+C G + K + L+ A +I L
Sbjct: 48 GTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGS 107
Query: 1387 EQWDVTLPVKEVKNTIAVDYHWDLKMIFYTDLDLNVIRSINMTN---MSESKTI-ISQKL 1442
+ ++ +T+ Y+ D+ + N ++ I +T +++ TI I Q
Sbjct: 108 KMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSF 167
Query: 1443 ETPNGLGVDWIANNIYWTDNEHKVIEVARLDGSSRKVLI-TGLTEPRALALFPAKG 1497
+ +DW+ N+Y+ D+ I V +GS LI L P+A+A+ P G
Sbjct: 168 HNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAG 223
Score = 36.7 bits (81), Expect = 0.76
Identities = 18/51 (35%), Positives = 28/51 (54%)
Query: 857 LAFDWITDKIYWTDGGTNRIEVSKSDGSMRTLLAWDHIDKPRDIVVNPEGG 907
+A DW+T +Y+ D +RI V S+GS+ L + P+ I V+P G
Sbjct: 173 MAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAG 223
>BC042754-1|AAH42754.2| 345|Homo sapiens low density lipoprotein
receptor class A domain containing 3 protein.
Length = 345
Score = 111 bits (266), Expect = 3e-23
Identities = 50/120 (41%), Positives = 66/120 (55%), Gaps = 2/120 (1%)
Query: 267 DFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDG-KCIPERWRCDN 325
+F C N +C+P +QCDG DC D +DE CP C F C G CI R+RC+
Sbjct: 34 NFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNG 93
Query: 326 ERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCE 385
DC DG DE NC N + CS Y C + C+ K+++CDG +C + DE +CE S E
Sbjct: 94 FEDCPDGSDEENCTANPLL-CSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQE 152
Score = 93.1 bits (221), Expect = 8e-18
Identities = 45/129 (34%), Positives = 64/129 (49%), Gaps = 15/129 (11%)
Query: 304 CNA-GEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADR-RCVLK 361
CN G F C++G+CIP W+CD DC D DE C P + C + CA C++
Sbjct: 29 CNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKEC-PKAKSKCGPTFFPCASGIHCIIG 87
Query: 362 TWLCDGVRDCTNGEDEMNCEVS---CEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDC 418
+ C+G DC +G DE NC + C +Y C+ N C+++ +CDG +C
Sbjct: 88 RFRCNGFEDCPDGSDEENCTANPLLCSTARYHCK-------NGL--CIDKSFICDGQNNC 138
Query: 419 PRGDDEERC 427
DEE C
Sbjct: 139 QDNSDEESC 147
Score = 67.3 bits (157), Expect = 5e-10
Identities = 27/84 (32%), Positives = 44/84 (52%), Gaps = 1/84 (1%)
Query: 257 PVELMRCAEIDFECKN-TKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK 315
P +C F C + C+ F+C+G DC D +DE++C P C+ + C +G
Sbjct: 65 PKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGL 124
Query: 316 CIPERWRCDNERDCADGGDELNCK 339
CI + + CD + +C D DE +C+
Sbjct: 125 CIDKSFICDGQNNCQDNSDEESCE 148
Score = 35.5 bits (78), Expect = 1.7
Identities = 34/151 (22%), Positives = 56/151 (37%), Gaps = 21/151 (13%)
Query: 393 PQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAA 452
P + SN C+ CDG+ DC DE+ CP A+ KC G
Sbjct: 32 PGNFMCSNG--RCIPGAWQCDGLPDCFDKSDEKECP-----KAKSKC---------GPTF 75
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPV-CSQT---CSNTVGSFRCG-CMTGYILRPDE 507
C G ++ C ++C D C+ CS + G C+ + +
Sbjct: 76 FPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQ 135
Query: 508 RSCKPTGESPTLLFSNRIGIRQVWLTGDNYM 538
+C+ + + S G QV++T +N +
Sbjct: 136 NNCQDNSDEESCESSQEPGSGQVFVTSENQL 166
Score = 34.7 bits (76), Expect = 3.1
Identities = 14/30 (46%), Positives = 20/30 (66%), Gaps = 1/30 (3%)
Query: 168 HSTN-VCIALEWLCDGDNDCGDFSDEINCD 196
H N +CI ++CDG N+C D SDE +C+
Sbjct: 119 HCKNGLCIDKSFICDGQNNCQDNSDEESCE 148
>AK075546-1|BAC11689.1| 345|Homo sapiens protein ( Homo sapiens
cDNA PSEC0246 fis, clone NT2RP3001359, weakly similar to
LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2
PRECURSOR. ).
Length = 345
Score = 111 bits (266), Expect = 3e-23
Identities = 50/120 (41%), Positives = 66/120 (55%), Gaps = 2/120 (1%)
Query: 267 DFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDG-KCIPERWRCDN 325
+F C N +C+P +QCDG DC D +DE CP C F C G CI R+RC+
Sbjct: 34 NFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNG 93
Query: 326 ERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCE 385
DC DG DE NC N + CS Y C + C+ K+++CDG +C + DE +CE S E
Sbjct: 94 FEDCPDGSDEENCTANPLL-CSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQE 152
Score = 93.1 bits (221), Expect = 8e-18
Identities = 45/129 (34%), Positives = 64/129 (49%), Gaps = 15/129 (11%)
Query: 304 CNA-GEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADR-RCVLK 361
CN G F C++G+CIP W+CD DC D DE C P + C + CA C++
Sbjct: 29 CNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKEC-PKAKSKCGPTFFPCASGIHCIIG 87
Query: 362 TWLCDGVRDCTNGEDEMNCEVS---CEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDC 418
+ C+G DC +G DE NC + C +Y C+ N C+++ +CDG +C
Sbjct: 88 RFRCNGFEDCPDGSDEENCTANPLLCSTARYHCK-------NGL--CIDKSFICDGQNNC 138
Query: 419 PRGDDEERC 427
DEE C
Sbjct: 139 QDNSDEESC 147
Score = 67.3 bits (157), Expect = 5e-10
Identities = 27/84 (32%), Positives = 44/84 (52%), Gaps = 1/84 (1%)
Query: 257 PVELMRCAEIDFECKN-TKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK 315
P +C F C + C+ F+C+G DC D +DE++C P C+ + C +G
Sbjct: 65 PKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGL 124
Query: 316 CIPERWRCDNERDCADGGDELNCK 339
CI + + CD + +C D DE +C+
Sbjct: 125 CIDKSFICDGQNNCQDNSDEESCE 148
Score = 35.5 bits (78), Expect = 1.7
Identities = 34/151 (22%), Positives = 56/151 (37%), Gaps = 21/151 (13%)
Query: 393 PQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAA 452
P + SN C+ CDG+ DC DE+ CP A+ KC G
Sbjct: 32 PGNFMCSNG--RCIPGAWQCDGLPDCFDKSDEKECP-----KAKSKC---------GPTF 75
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPV-CSQT---CSNTVGSFRCG-CMTGYILRPDE 507
C G ++ C ++C D C+ CS + G C+ + +
Sbjct: 76 FPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQ 135
Query: 508 RSCKPTGESPTLLFSNRIGIRQVWLTGDNYM 538
+C+ + + S G QV++T +N +
Sbjct: 136 NNCQDNSDEESCESSQEPGSGQVFVTSENQL 166
Score = 34.7 bits (76), Expect = 3.1
Identities = 14/30 (46%), Positives = 20/30 (66%), Gaps = 1/30 (3%)
Query: 168 HSTN-VCIALEWLCDGDNDCGDFSDEINCD 196
H N +CI ++CDG N+C D SDE +C+
Sbjct: 119 HCKNGLCIDKSFICDGQNNCQDNSDEESCE 148
>BC030532-1|AAH30532.1| 855|Homo sapiens suppression of
tumorigenicity 14 (colon carcinoma) protein.
Length = 855
Score = 107 bits (258), Expect = 3e-22
Identities = 55/162 (33%), Positives = 85/162 (52%), Gaps = 18/162 (11%)
Query: 268 FECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAG-EFKCNDGKCIPERWRCDNE 326
F C+ +C+ K+ +CDG DC D +DE +C SC+AG +F C + C P W CD+
Sbjct: 457 FTCRTGRCIRKELRCDGWADCTDHSDELNC-----SCDAGHQFTCKNKFCKPLFWVCDSV 511
Query: 327 RDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEE 386
DC D DE C +C + C++ +C+ K+ C+G DC +G DE +C +
Sbjct: 512 NDCGDNSDEQGC------SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCP---KV 562
Query: 387 DQYTCRPQEHLMSNAFRNCVNRKH-VCDGMKDCPRGDDEERC 427
+ TC + N C+++ + CDG +DC G DE+ C
Sbjct: 563 NVVTCTKHTYRCLNGL--CLSKGNPECDGKEDCSDGSDEKDC 602
Score = 105 bits (251), Expect = 2e-21
Identities = 46/115 (40%), Positives = 66/115 (57%), Gaps = 6/115 (5%)
Query: 268 FECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNER 327
F CKN C P + CD NDCGD +DE C SC A F+C++GKC+ + +C+ +
Sbjct: 494 FTCKNKFCKPLFWVCDSVNDCGDNSDEQGC-----SCPAQTFRCSNGKCLSKSQQCNGKD 548
Query: 328 DCADGGDELNCKPNSIRNCSLDEYTCADRRCVLK-TWLCDGVRDCTNGEDEMNCE 381
DC DG DE +C ++ C+ Y C + C+ K CDG DC++G DE +C+
Sbjct: 549 DCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCD 603
Score = 89.4 bits (212), Expect = 1e-16
Identities = 45/123 (36%), Positives = 60/123 (48%), Gaps = 18/123 (14%)
Query: 307 GEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSL-DEYTCADRRCVLKTWLC 365
G+F C G+CI + RCD DC D DELNC +C ++TC ++ C W+C
Sbjct: 455 GQFTCRTGRCIRKELRCDGWADCTDHSDELNC------SCDAGHQFTCKNKFCKPLFWVC 508
Query: 366 DGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEE 425
D V DC + DE C SC + C SN C+++ C+G DC G DE
Sbjct: 509 DSVNDCGDNSDEQGC--SCPAQTFRC-------SNG--KCLSKSQQCNGKDDCGDGSDEA 557
Query: 426 RCP 428
CP
Sbjct: 558 SCP 560
Score = 77.4 bits (182), Expect = 4e-13
Identities = 33/78 (42%), Positives = 46/78 (58%), Gaps = 2/78 (2%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMV-PGSCNAGEFKCNDGKCIPE-R 320
C F C N KC+ K QC+G +DCGD +DE SCP V +C ++C +G C+ +
Sbjct: 525 CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGN 584
Query: 321 WRCDNERDCADGGDELNC 338
CD + DC+DG DE +C
Sbjct: 585 PECDGKEDCSDGSDEKDC 602
Score = 47.2 bits (107), Expect = 5e-04
Identities = 40/143 (27%), Positives = 57/143 (39%), Gaps = 16/143 (11%)
Query: 170 TNVCIALEWLCDGDNDCGDFSDEINCD-------VVKTSLLVPSANASLNIGDVITNPTV 222
T CI E CDG DC D SDE+NC K P ++ D N
Sbjct: 461 TGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDE 520
Query: 223 LIALTKPTVVIRYES-FCAKKA-----LDNAANPRSTWNQP-VELMRCAEIDFECKNTKC 275
+ P R + C K+ D+ + + P V ++ C + + C N C
Sbjct: 521 Q-GCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLC 579
Query: 276 VPK-DFQCDGDNDCGDWTDEDSC 297
+ K + +CDG DC D +DE C
Sbjct: 580 LSKGNPECDGKEDCSDGSDEKDC 602
Score = 33.5 bits (73), Expect = 7.0
Identities = 13/30 (43%), Positives = 18/30 (60%)
Query: 169 STNVCIALEWLCDGDNDCGDFSDEINCDVV 198
S C++ C+G +DCGD SDE +C V
Sbjct: 533 SNGKCLSKSQQCNGKDDCGDGSDEASCPKV 562
>BC018146-1|AAH18146.1| 422|Homo sapiens ST14 protein protein.
Length = 422
Score = 107 bits (258), Expect = 3e-22
Identities = 55/162 (33%), Positives = 85/162 (52%), Gaps = 18/162 (11%)
Query: 268 FECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAG-EFKCNDGKCIPERWRCDNE 326
F C+ +C+ K+ +CDG DC D +DE +C SC+AG +F C + C P W CD+
Sbjct: 24 FTCRTGRCIRKELRCDGWADCTDHSDELNC-----SCDAGHQFTCKNKFCKPLFWVCDSV 78
Query: 327 RDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEE 386
DC D DE C +C + C++ +C+ K+ C+G DC +G DE +C +
Sbjct: 79 NDCGDNSDEQGC------SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCP---KV 129
Query: 387 DQYTCRPQEHLMSNAFRNCVNRKH-VCDGMKDCPRGDDEERC 427
+ TC + N C+++ + CDG +DC G DE+ C
Sbjct: 130 NVVTCTKHTYRCLNGL--CLSKGNPECDGKEDCSDGSDEKDC 169
Score = 105 bits (251), Expect = 2e-21
Identities = 46/115 (40%), Positives = 66/115 (57%), Gaps = 6/115 (5%)
Query: 268 FECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNER 327
F CKN C P + CD NDCGD +DE C SC A F+C++GKC+ + +C+ +
Sbjct: 61 FTCKNKFCKPLFWVCDSVNDCGDNSDEQGC-----SCPAQTFRCSNGKCLSKSQQCNGKD 115
Query: 328 DCADGGDELNCKPNSIRNCSLDEYTCADRRCVLK-TWLCDGVRDCTNGEDEMNCE 381
DC DG DE +C ++ C+ Y C + C+ K CDG DC++G DE +C+
Sbjct: 116 DCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCD 170
Score = 89.4 bits (212), Expect = 1e-16
Identities = 45/123 (36%), Positives = 60/123 (48%), Gaps = 18/123 (14%)
Query: 307 GEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSL-DEYTCADRRCVLKTWLC 365
G+F C G+CI + RCD DC D DELNC +C ++TC ++ C W+C
Sbjct: 22 GQFTCRTGRCIRKELRCDGWADCTDHSDELNC------SCDAGHQFTCKNKFCKPLFWVC 75
Query: 366 DGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEE 425
D V DC + DE C SC + C SN C+++ C+G DC G DE
Sbjct: 76 DSVNDCGDNSDEQGC--SCPAQTFRC-------SNG--KCLSKSQQCNGKDDCGDGSDEA 124
Query: 426 RCP 428
CP
Sbjct: 125 SCP 127
Score = 77.4 bits (182), Expect = 4e-13
Identities = 33/78 (42%), Positives = 46/78 (58%), Gaps = 2/78 (2%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMV-PGSCNAGEFKCNDGKCIPE-R 320
C F C N KC+ K QC+G +DCGD +DE SCP V +C ++C +G C+ +
Sbjct: 92 CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGN 151
Query: 321 WRCDNERDCADGGDELNC 338
CD + DC+DG DE +C
Sbjct: 152 PECDGKEDCSDGSDEKDC 169
Score = 47.2 bits (107), Expect = 5e-04
Identities = 40/143 (27%), Positives = 57/143 (39%), Gaps = 16/143 (11%)
Query: 170 TNVCIALEWLCDGDNDCGDFSDEINCD-------VVKTSLLVPSANASLNIGDVITNPTV 222
T CI E CDG DC D SDE+NC K P ++ D N
Sbjct: 28 TGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDE 87
Query: 223 LIALTKPTVVIRYES-FCAKKA-----LDNAANPRSTWNQP-VELMRCAEIDFECKNTKC 275
+ P R + C K+ D+ + + P V ++ C + + C N C
Sbjct: 88 Q-GCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLC 146
Query: 276 VPK-DFQCDGDNDCGDWTDEDSC 297
+ K + +CDG DC D +DE C
Sbjct: 147 LSKGNPECDGKEDCSDGSDEKDC 169
Score = 33.5 bits (73), Expect = 7.0
Identities = 13/30 (43%), Positives = 18/30 (60%)
Query: 169 STNVCIALEWLCDGDNDCGDFSDEINCDVV 198
S C++ C+G +DCGD SDE +C V
Sbjct: 100 SNGKCLSKSQQCNGKDDCGDGSDEASCPKV 129
>BC005826-1|AAH05826.2| 526|Homo sapiens ST14 protein protein.
Length = 526
Score = 107 bits (258), Expect = 3e-22
Identities = 55/162 (33%), Positives = 85/162 (52%), Gaps = 18/162 (11%)
Query: 268 FECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAG-EFKCNDGKCIPERWRCDNE 326
F C+ +C+ K+ +CDG DC D +DE +C SC+AG +F C + C P W CD+
Sbjct: 128 FTCRTGRCIRKELRCDGWADCTDHSDELNC-----SCDAGHQFTCKNKFCKPLFWVCDSV 182
Query: 327 RDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEE 386
DC D DE C +C + C++ +C+ K+ C+G DC +G DE +C +
Sbjct: 183 NDCGDNSDEQGC------SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCP---KV 233
Query: 387 DQYTCRPQEHLMSNAFRNCVNRKH-VCDGMKDCPRGDDEERC 427
+ TC + N C+++ + CDG +DC G DE+ C
Sbjct: 234 NVVTCTKHTYRCLNGL--CLSKGNPECDGKEDCSDGSDEKDC 273
Score = 105 bits (251), Expect = 2e-21
Identities = 46/115 (40%), Positives = 66/115 (57%), Gaps = 6/115 (5%)
Query: 268 FECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNER 327
F CKN C P + CD NDCGD +DE C SC A F+C++GKC+ + +C+ +
Sbjct: 165 FTCKNKFCKPLFWVCDSVNDCGDNSDEQGC-----SCPAQTFRCSNGKCLSKSQQCNGKD 219
Query: 328 DCADGGDELNCKPNSIRNCSLDEYTCADRRCVLK-TWLCDGVRDCTNGEDEMNCE 381
DC DG DE +C ++ C+ Y C + C+ K CDG DC++G DE +C+
Sbjct: 220 DCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCD 274
Score = 89.4 bits (212), Expect = 1e-16
Identities = 45/123 (36%), Positives = 60/123 (48%), Gaps = 18/123 (14%)
Query: 307 GEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSL-DEYTCADRRCVLKTWLC 365
G+F C G+CI + RCD DC D DELNC +C ++TC ++ C W+C
Sbjct: 126 GQFTCRTGRCIRKELRCDGWADCTDHSDELNC------SCDAGHQFTCKNKFCKPLFWVC 179
Query: 366 DGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEE 425
D V DC + DE C SC + C SN C+++ C+G DC G DE
Sbjct: 180 DSVNDCGDNSDEQGC--SCPAQTFRC-------SNG--KCLSKSQQCNGKDDCGDGSDEA 228
Query: 426 RCP 428
CP
Sbjct: 229 SCP 231
Score = 77.4 bits (182), Expect = 4e-13
Identities = 33/78 (42%), Positives = 46/78 (58%), Gaps = 2/78 (2%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMV-PGSCNAGEFKCNDGKCIPE-R 320
C F C N KC+ K QC+G +DCGD +DE SCP V +C ++C +G C+ +
Sbjct: 196 CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGN 255
Query: 321 WRCDNERDCADGGDELNC 338
CD + DC+DG DE +C
Sbjct: 256 PECDGKEDCSDGSDEKDC 273
Score = 47.2 bits (107), Expect = 5e-04
Identities = 40/143 (27%), Positives = 57/143 (39%), Gaps = 16/143 (11%)
Query: 170 TNVCIALEWLCDGDNDCGDFSDEINCD-------VVKTSLLVPSANASLNIGDVITNPTV 222
T CI E CDG DC D SDE+NC K P ++ D N
Sbjct: 132 TGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDE 191
Query: 223 LIALTKPTVVIRYES-FCAKKA-----LDNAANPRSTWNQP-VELMRCAEIDFECKNTKC 275
+ P R + C K+ D+ + + P V ++ C + + C N C
Sbjct: 192 Q-GCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLC 250
Query: 276 VPK-DFQCDGDNDCGDWTDEDSC 297
+ K + +CDG DC D +DE C
Sbjct: 251 LSKGNPECDGKEDCSDGSDEKDC 273
Score = 33.5 bits (73), Expect = 7.0
Identities = 13/30 (43%), Positives = 18/30 (60%)
Query: 169 STNVCIALEWLCDGDNDCGDFSDEINCDVV 198
S C++ C+G +DCGD SDE +C V
Sbjct: 204 SNGKCLSKSQQCNGKDDCGDGSDEASCPKV 233
>AF283256-1|AAG13949.1| 325|Homo sapiens serine protease SNC19
protein.
Length = 325
Score = 107 bits (258), Expect = 3e-22
Identities = 55/162 (33%), Positives = 85/162 (52%), Gaps = 18/162 (11%)
Query: 268 FECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAG-EFKCNDGKCIPERWRCDNE 326
F C+ +C+ K+ +CDG DC D +DE +C SC+AG +F C + C P W CD+
Sbjct: 118 FTCRTGRCIRKELRCDGWADCTDHSDELNC-----SCDAGHQFTCKNKFCKPLFWVCDSV 172
Query: 327 RDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEE 386
DC D DE C +C + C++ +C+ K+ C+G DC +G DE +C +
Sbjct: 173 NDCGDNSDEQGC------SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCP---KV 223
Query: 387 DQYTCRPQEHLMSNAFRNCVNRKH-VCDGMKDCPRGDDEERC 427
+ TC + N C+++ + CDG +DC G DE+ C
Sbjct: 224 NVVTCTKHTYRCLNGL--CLSKGNPECDGKEDCSDGSDEKDC 263
Score = 105 bits (251), Expect = 2e-21
Identities = 46/115 (40%), Positives = 66/115 (57%), Gaps = 6/115 (5%)
Query: 268 FECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNER 327
F CKN C P + CD NDCGD +DE C SC A F+C++GKC+ + +C+ +
Sbjct: 155 FTCKNKFCKPLFWVCDSVNDCGDNSDEQGC-----SCPAQTFRCSNGKCLSKSQQCNGKD 209
Query: 328 DCADGGDELNCKPNSIRNCSLDEYTCADRRCVLK-TWLCDGVRDCTNGEDEMNCE 381
DC DG DE +C ++ C+ Y C + C+ K CDG DC++G DE +C+
Sbjct: 210 DCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCD 264
Score = 89.4 bits (212), Expect = 1e-16
Identities = 45/123 (36%), Positives = 60/123 (48%), Gaps = 18/123 (14%)
Query: 307 GEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSL-DEYTCADRRCVLKTWLC 365
G+F C G+CI + RCD DC D DELNC +C ++TC ++ C W+C
Sbjct: 116 GQFTCRTGRCIRKELRCDGWADCTDHSDELNC------SCDAGHQFTCKNKFCKPLFWVC 169
Query: 366 DGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEE 425
D V DC + DE C SC + C SN C+++ C+G DC G DE
Sbjct: 170 DSVNDCGDNSDEQGC--SCPAQTFRC-------SNG--KCLSKSQQCNGKDDCGDGSDEA 218
Query: 426 RCP 428
CP
Sbjct: 219 SCP 221
Score = 77.4 bits (182), Expect = 4e-13
Identities = 33/78 (42%), Positives = 46/78 (58%), Gaps = 2/78 (2%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMV-PGSCNAGEFKCNDGKCIPE-R 320
C F C N KC+ K QC+G +DCGD +DE SCP V +C ++C +G C+ +
Sbjct: 186 CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGN 245
Query: 321 WRCDNERDCADGGDELNC 338
CD + DC+DG DE +C
Sbjct: 246 PECDGKEDCSDGSDEKDC 263
Score = 47.2 bits (107), Expect = 5e-04
Identities = 40/143 (27%), Positives = 57/143 (39%), Gaps = 16/143 (11%)
Query: 170 TNVCIALEWLCDGDNDCGDFSDEINCD-------VVKTSLLVPSANASLNIGDVITNPTV 222
T CI E CDG DC D SDE+NC K P ++ D N
Sbjct: 122 TGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDE 181
Query: 223 LIALTKPTVVIRYES-FCAKKA-----LDNAANPRSTWNQP-VELMRCAEIDFECKNTKC 275
+ P R + C K+ D+ + + P V ++ C + + C N C
Sbjct: 182 Q-GCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLC 240
Query: 276 VPK-DFQCDGDNDCGDWTDEDSC 297
+ K + +CDG DC D +DE C
Sbjct: 241 LSKGNPECDGKEDCSDGSDEKDC 263
Score = 33.5 bits (73), Expect = 7.0
Identities = 13/30 (43%), Positives = 18/30 (60%)
Query: 169 STNVCIALEWLCDGDNDCGDFSDEINCDVV 198
S C++ C+G +DCGD SDE +C V
Sbjct: 194 SNGKCLSKSQQCNGKDDCGDGSDEASCPKV 223
>AF133086-1|AAF00109.1| 855|Homo sapiens membrane-type serine
protease 1 protein.
Length = 855
Score = 107 bits (258), Expect = 3e-22
Identities = 55/162 (33%), Positives = 85/162 (52%), Gaps = 18/162 (11%)
Query: 268 FECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAG-EFKCNDGKCIPERWRCDNE 326
F C+ +C+ K+ +CDG DC D +DE +C SC+AG +F C + C P W CD+
Sbjct: 457 FTCRTGRCIRKELRCDGWADCTDHSDELNC-----SCDAGHQFTCKNKFCKPLFWVCDSV 511
Query: 327 RDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEE 386
DC D DE C +C + C++ +C+ K+ C+G DC +G DE +C +
Sbjct: 512 NDCGDNSDEQGC------SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCP---KV 562
Query: 387 DQYTCRPQEHLMSNAFRNCVNRKH-VCDGMKDCPRGDDEERC 427
+ TC + N C+++ + CDG +DC G DE+ C
Sbjct: 563 NVVTCTKHTYRCLNGL--CLSKGNPECDGKEDCSDGSDEKDC 602
Score = 105 bits (251), Expect = 2e-21
Identities = 46/115 (40%), Positives = 66/115 (57%), Gaps = 6/115 (5%)
Query: 268 FECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNER 327
F CKN C P + CD NDCGD +DE C SC A F+C++GKC+ + +C+ +
Sbjct: 494 FTCKNKFCKPLFWVCDSVNDCGDNSDEQGC-----SCPAQTFRCSNGKCLSKSQQCNGKD 548
Query: 328 DCADGGDELNCKPNSIRNCSLDEYTCADRRCVLK-TWLCDGVRDCTNGEDEMNCE 381
DC DG DE +C ++ C+ Y C + C+ K CDG DC++G DE +C+
Sbjct: 549 DCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCD 603
Score = 89.4 bits (212), Expect = 1e-16
Identities = 45/123 (36%), Positives = 60/123 (48%), Gaps = 18/123 (14%)
Query: 307 GEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSL-DEYTCADRRCVLKTWLC 365
G+F C G+CI + RCD DC D DELNC +C ++TC ++ C W+C
Sbjct: 455 GQFTCRTGRCIRKELRCDGWADCTDHSDELNC------SCDAGHQFTCKNKFCKPLFWVC 508
Query: 366 DGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEE 425
D V DC + DE C SC + C SN C+++ C+G DC G DE
Sbjct: 509 DSVNDCGDNSDEQGC--SCPAQTFRC-------SNG--KCLSKSQQCNGKDDCGDGSDEA 557
Query: 426 RCP 428
CP
Sbjct: 558 SCP 560
Score = 77.4 bits (182), Expect = 4e-13
Identities = 33/78 (42%), Positives = 46/78 (58%), Gaps = 2/78 (2%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMV-PGSCNAGEFKCNDGKCIPE-R 320
C F C N KC+ K QC+G +DCGD +DE SCP V +C ++C +G C+ +
Sbjct: 525 CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGN 584
Query: 321 WRCDNERDCADGGDELNC 338
CD + DC+DG DE +C
Sbjct: 585 PECDGKEDCSDGSDEKDC 602
Score = 47.2 bits (107), Expect = 5e-04
Identities = 40/143 (27%), Positives = 57/143 (39%), Gaps = 16/143 (11%)
Query: 170 TNVCIALEWLCDGDNDCGDFSDEINCD-------VVKTSLLVPSANASLNIGDVITNPTV 222
T CI E CDG DC D SDE+NC K P ++ D N
Sbjct: 461 TGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDE 520
Query: 223 LIALTKPTVVIRYES-FCAKKA-----LDNAANPRSTWNQP-VELMRCAEIDFECKNTKC 275
+ P R + C K+ D+ + + P V ++ C + + C N C
Sbjct: 521 Q-GCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLC 579
Query: 276 VPK-DFQCDGDNDCGDWTDEDSC 297
+ K + +CDG DC D +DE C
Sbjct: 580 LSKGNPECDGKEDCSDGSDEKDC 602
Score = 33.5 bits (73), Expect = 7.0
Identities = 13/30 (43%), Positives = 18/30 (60%)
Query: 169 STNVCIALEWLCDGDNDCGDFSDEINCDVV 198
S C++ C+G +DCGD SDE +C V
Sbjct: 533 SNGKCLSKSQQCNGKDDCGDGSDEASCPKV 562
>AF118224-1|AAD42765.2| 855|Homo sapiens matriptase protein.
Length = 855
Score = 107 bits (258), Expect = 3e-22
Identities = 55/162 (33%), Positives = 85/162 (52%), Gaps = 18/162 (11%)
Query: 268 FECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAG-EFKCNDGKCIPERWRCDNE 326
F C+ +C+ K+ +CDG DC D +DE +C SC+AG +F C + C P W CD+
Sbjct: 457 FTCRTGRCIRKELRCDGWADCTDHSDELNC-----SCDAGHQFTCKNKFCKPLFWVCDSV 511
Query: 327 RDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEE 386
DC D DE C +C + C++ +C+ K+ C+G DC +G DE +C +
Sbjct: 512 NDCGDNSDEQGC------SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCP---KV 562
Query: 387 DQYTCRPQEHLMSNAFRNCVNRKH-VCDGMKDCPRGDDEERC 427
+ TC + N C+++ + CDG +DC G DE+ C
Sbjct: 563 NVVTCTKHTYRCLNGL--CLSKGNPECDGKEDCSDGSDEKDC 602
Score = 105 bits (251), Expect = 2e-21
Identities = 46/115 (40%), Positives = 66/115 (57%), Gaps = 6/115 (5%)
Query: 268 FECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNER 327
F CKN C P + CD NDCGD +DE C SC A F+C++GKC+ + +C+ +
Sbjct: 494 FTCKNKFCKPLFWVCDSVNDCGDNSDEQGC-----SCPAQTFRCSNGKCLSKSQQCNGKD 548
Query: 328 DCADGGDELNCKPNSIRNCSLDEYTCADRRCVLK-TWLCDGVRDCTNGEDEMNCE 381
DC DG DE +C ++ C+ Y C + C+ K CDG DC++G DE +C+
Sbjct: 549 DCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCD 603
Score = 89.4 bits (212), Expect = 1e-16
Identities = 45/123 (36%), Positives = 60/123 (48%), Gaps = 18/123 (14%)
Query: 307 GEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSL-DEYTCADRRCVLKTWLC 365
G+F C G+CI + RCD DC D DELNC +C ++TC ++ C W+C
Sbjct: 455 GQFTCRTGRCIRKELRCDGWADCTDHSDELNC------SCDAGHQFTCKNKFCKPLFWVC 508
Query: 366 DGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEE 425
D V DC + DE C SC + C SN C+++ C+G DC G DE
Sbjct: 509 DSVNDCGDNSDEQGC--SCPAQTFRC-------SNG--KCLSKSQQCNGKDDCGDGSDEA 557
Query: 426 RCP 428
CP
Sbjct: 558 SCP 560
Score = 77.4 bits (182), Expect = 4e-13
Identities = 33/78 (42%), Positives = 46/78 (58%), Gaps = 2/78 (2%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMV-PGSCNAGEFKCNDGKCIPE-R 320
C F C N KC+ K QC+G +DCGD +DE SCP V +C ++C +G C+ +
Sbjct: 525 CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGN 584
Query: 321 WRCDNERDCADGGDELNC 338
CD + DC+DG DE +C
Sbjct: 585 PECDGKEDCSDGSDEKDC 602
Score = 47.2 bits (107), Expect = 5e-04
Identities = 40/143 (27%), Positives = 57/143 (39%), Gaps = 16/143 (11%)
Query: 170 TNVCIALEWLCDGDNDCGDFSDEINCD-------VVKTSLLVPSANASLNIGDVITNPTV 222
T CI E CDG DC D SDE+NC K P ++ D N
Sbjct: 461 TGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDE 520
Query: 223 LIALTKPTVVIRYES-FCAKKA-----LDNAANPRSTWNQP-VELMRCAEIDFECKNTKC 275
+ P R + C K+ D+ + + P V ++ C + + C N C
Sbjct: 521 Q-GCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLC 579
Query: 276 VPK-DFQCDGDNDCGDWTDEDSC 297
+ K + +CDG DC D +DE C
Sbjct: 580 LSKGNPECDGKEDCSDGSDEKDC 602
Score = 33.5 bits (73), Expect = 7.0
Identities = 13/30 (43%), Positives = 18/30 (60%)
Query: 169 STNVCIALEWLCDGDNDCGDFSDEINCDVV 198
S C++ C+G +DCGD SDE +C V
Sbjct: 533 SNGKCLSKSQQCNGKDDCGDGSDEASCPKV 562
>AF057145-1|AAG15395.1| 855|Homo sapiens serine protease TADG15
protein.
Length = 855
Score = 107 bits (258), Expect = 3e-22
Identities = 55/162 (33%), Positives = 85/162 (52%), Gaps = 18/162 (11%)
Query: 268 FECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAG-EFKCNDGKCIPERWRCDNE 326
F C+ +C+ K+ +CDG DC D +DE +C SC+AG +F C + C P W CD+
Sbjct: 457 FTCRTGRCIRKELRCDGWADCTDHSDELNC-----SCDAGHQFTCKNKFCKPLFWVCDSV 511
Query: 327 RDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEE 386
DC D DE C +C + C++ +C+ K+ C+G DC +G DE +C +
Sbjct: 512 NDCGDNSDEQGC------SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCP---KV 562
Query: 387 DQYTCRPQEHLMSNAFRNCVNRKH-VCDGMKDCPRGDDEERC 427
+ TC + N C+++ + CDG +DC G DE+ C
Sbjct: 563 NVVTCTKHTYRCLNGL--CLSKGNPECDGKEDCSDGSDEKDC 602
Score = 105 bits (251), Expect = 2e-21
Identities = 46/115 (40%), Positives = 66/115 (57%), Gaps = 6/115 (5%)
Query: 268 FECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNER 327
F CKN C P + CD NDCGD +DE C SC A F+C++GKC+ + +C+ +
Sbjct: 494 FTCKNKFCKPLFWVCDSVNDCGDNSDEQGC-----SCPAQTFRCSNGKCLSKSQQCNGKD 548
Query: 328 DCADGGDELNCKPNSIRNCSLDEYTCADRRCVLK-TWLCDGVRDCTNGEDEMNCE 381
DC DG DE +C ++ C+ Y C + C+ K CDG DC++G DE +C+
Sbjct: 549 DCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCD 603
Score = 89.4 bits (212), Expect = 1e-16
Identities = 45/123 (36%), Positives = 60/123 (48%), Gaps = 18/123 (14%)
Query: 307 GEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSL-DEYTCADRRCVLKTWLC 365
G+F C G+CI + RCD DC D DELNC +C ++TC ++ C W+C
Sbjct: 455 GQFTCRTGRCIRKELRCDGWADCTDHSDELNC------SCDAGHQFTCKNKFCKPLFWVC 508
Query: 366 DGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEE 425
D V DC + DE C SC + C SN C+++ C+G DC G DE
Sbjct: 509 DSVNDCGDNSDEQGC--SCPAQTFRC-------SNG--KCLSKSQQCNGKDDCGDGSDEA 557
Query: 426 RCP 428
CP
Sbjct: 558 SCP 560
Score = 77.4 bits (182), Expect = 4e-13
Identities = 33/78 (42%), Positives = 46/78 (58%), Gaps = 2/78 (2%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMV-PGSCNAGEFKCNDGKCIPE-R 320
C F C N KC+ K QC+G +DCGD +DE SCP V +C ++C +G C+ +
Sbjct: 525 CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGN 584
Query: 321 WRCDNERDCADGGDELNC 338
CD + DC+DG DE +C
Sbjct: 585 PECDGKEDCSDGSDEKDC 602
Score = 47.2 bits (107), Expect = 5e-04
Identities = 40/143 (27%), Positives = 57/143 (39%), Gaps = 16/143 (11%)
Query: 170 TNVCIALEWLCDGDNDCGDFSDEINCD-------VVKTSLLVPSANASLNIGDVITNPTV 222
T CI E CDG DC D SDE+NC K P ++ D N
Sbjct: 461 TGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDE 520
Query: 223 LIALTKPTVVIRYES-FCAKKA-----LDNAANPRSTWNQP-VELMRCAEIDFECKNTKC 275
+ P R + C K+ D+ + + P V ++ C + + C N C
Sbjct: 521 Q-GCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLC 579
Query: 276 VPK-DFQCDGDNDCGDWTDEDSC 297
+ K + +CDG DC D +DE C
Sbjct: 580 LSKGNPECDGKEDCSDGSDEKDC 602
Score = 33.5 bits (73), Expect = 7.0
Identities = 13/30 (43%), Positives = 18/30 (60%)
Query: 169 STNVCIALEWLCDGDNDCGDFSDEINCDVV 198
S C++ C+G +DCGD SDE +C V
Sbjct: 533 SNGKCLSKSQQCNGKDDCGDGSDEASCPKV 562
>AB030036-1|BAB20376.1| 855|Homo sapiens prostamin protein.
Length = 855
Score = 107 bits (258), Expect = 3e-22
Identities = 55/162 (33%), Positives = 85/162 (52%), Gaps = 18/162 (11%)
Query: 268 FECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAG-EFKCNDGKCIPERWRCDNE 326
F C+ +C+ K+ +CDG DC D +DE +C SC+AG +F C + C P W CD+
Sbjct: 457 FTCRTGRCIRKELRCDGWADCTDHSDELNC-----SCDAGHQFTCKNKFCKPLFWVCDSV 511
Query: 327 RDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEE 386
DC D DE C +C + C++ +C+ K+ C+G DC +G DE +C +
Sbjct: 512 NDCGDNSDEQGC------SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCP---KV 562
Query: 387 DQYTCRPQEHLMSNAFRNCVNRKH-VCDGMKDCPRGDDEERC 427
+ TC + N C+++ + CDG +DC G DE+ C
Sbjct: 563 NVVTCTKHTYRCLNGL--CLSKGNPECDGKEDCSDGSDEKDC 602
Score = 105 bits (251), Expect = 2e-21
Identities = 46/115 (40%), Positives = 66/115 (57%), Gaps = 6/115 (5%)
Query: 268 FECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNER 327
F CKN C P + CD NDCGD +DE C SC A F+C++GKC+ + +C+ +
Sbjct: 494 FTCKNKFCKPLFWVCDSVNDCGDNSDEQGC-----SCPAQTFRCSNGKCLSKSQQCNGKD 548
Query: 328 DCADGGDELNCKPNSIRNCSLDEYTCADRRCVLK-TWLCDGVRDCTNGEDEMNCE 381
DC DG DE +C ++ C+ Y C + C+ K CDG DC++G DE +C+
Sbjct: 549 DCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCD 603
Score = 89.4 bits (212), Expect = 1e-16
Identities = 45/123 (36%), Positives = 60/123 (48%), Gaps = 18/123 (14%)
Query: 307 GEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSL-DEYTCADRRCVLKTWLC 365
G+F C G+CI + RCD DC D DELNC +C ++TC ++ C W+C
Sbjct: 455 GQFTCRTGRCIRKELRCDGWADCTDHSDELNC------SCDAGHQFTCKNKFCKPLFWVC 508
Query: 366 DGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEE 425
D V DC + DE C SC + C SN C+++ C+G DC G DE
Sbjct: 509 DSVNDCGDNSDEQGC--SCPAQTFRC-------SNG--KCLSKSQQCNGKDDCGDGSDEA 557
Query: 426 RCP 428
CP
Sbjct: 558 SCP 560
Score = 77.4 bits (182), Expect = 4e-13
Identities = 33/78 (42%), Positives = 46/78 (58%), Gaps = 2/78 (2%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMV-PGSCNAGEFKCNDGKCIPE-R 320
C F C N KC+ K QC+G +DCGD +DE SCP V +C ++C +G C+ +
Sbjct: 525 CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGN 584
Query: 321 WRCDNERDCADGGDELNC 338
CD + DC+DG DE +C
Sbjct: 585 PECDGKEDCSDGSDEKDC 602
Score = 47.2 bits (107), Expect = 5e-04
Identities = 40/143 (27%), Positives = 57/143 (39%), Gaps = 16/143 (11%)
Query: 170 TNVCIALEWLCDGDNDCGDFSDEINCD-------VVKTSLLVPSANASLNIGDVITNPTV 222
T CI E CDG DC D SDE+NC K P ++ D N
Sbjct: 461 TGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDE 520
Query: 223 LIALTKPTVVIRYES-FCAKKA-----LDNAANPRSTWNQP-VELMRCAEIDFECKNTKC 275
+ P R + C K+ D+ + + P V ++ C + + C N C
Sbjct: 521 Q-GCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLC 579
Query: 276 VPK-DFQCDGDNDCGDWTDEDSC 297
+ K + +CDG DC D +DE C
Sbjct: 580 LSKGNPECDGKEDCSDGSDEKDC 602
Score = 33.5 bits (73), Expect = 7.0
Identities = 13/30 (43%), Positives = 18/30 (60%)
Query: 169 STNVCIALEWLCDGDNDCGDFSDEINCDVV 198
S C++ C+G +DCGD SDE +C V
Sbjct: 533 SNGKCLSKSQQCNGKDDCGDGSDEASCPKV 562
>AL590103-10|CAI12134.1| 179|Homo sapiens heparan sulfate
proteoglycan 2 (perlecan) protein.
Length = 179
Score = 102 bits (245), Expect = 1e-20
Identities = 58/176 (32%), Positives = 83/176 (47%), Gaps = 20/176 (11%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
R+C E E CHS N C+ALE+ CD DC D SDE+NC+ + P+ + +
Sbjct: 23 RACTEAE--FACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGIS-PTFSLLVETTS 79
Query: 216 VITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKC 275
+ P I + +P V + + L + P + C + C+N C
Sbjct: 80 LPPRPETTI-MRQPPV-----THAPQPLLPGSVRP----------LPCGPQEAACRNGHC 123
Query: 276 VPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCAD 331
+P+D+ CDG DC D +DE C P C EF C +G C + WRCD + DC D
Sbjct: 124 IPRDYLCDGQEDCEDGSDELDCG-PPPPCEPNEFPCGNGHCALKLWRCDGDFDCED 178
Score = 77.4 bits (182), Expect = 4e-13
Identities = 34/79 (43%), Positives = 43/79 (54%), Gaps = 7/79 (8%)
Query: 298 PMVPGS-----CNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYT 352
P++PGS C E C +G CIP + CD + DC DG DEL+C P C +E+
Sbjct: 100 PLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPPP--PCEPNEFP 157
Query: 353 CADRRCVLKTWLCDGVRDC 371
C + C LK W CDG DC
Sbjct: 158 CGNGHCALKLWRCDGDFDC 176
Score = 65.3 bits (152), Expect = 2e-09
Identities = 44/159 (27%), Positives = 65/159 (40%), Gaps = 10/159 (6%)
Query: 263 CAEIDFECKN-TKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
C E +F C + +CV +++CD DC D +DE +C + + +P R
Sbjct: 25 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRP 84
Query: 322 RCDNERDCADGGDELNCKPNSIRN--CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMN 379
R P S+R C E C + C+ + +LCDG DC +G DE++
Sbjct: 85 ETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELD 144
Query: 380 CEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDC 418
C C P E N +C + CDG DC
Sbjct: 145 C-----GPPPPCEPNEFPCGNG--HCALKLWRCDGDFDC 176
Score = 46.8 bits (106), Expect = 7e-04
Identities = 18/43 (41%), Positives = 24/43 (55%), Gaps = 1/43 (2%)
Query: 298 PMVPGSCNAGEFKCND-GKCIPERWRCDNERDCADGGDELNCK 339
P P +C EF C+ +C+ +RCD DC D DELNC+
Sbjct: 19 PQFPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCE 61
Score = 39.9 bits (89), Expect = 0.081
Identities = 18/47 (38%), Positives = 23/47 (48%), Gaps = 2/47 (4%)
Query: 391 CRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE 437
C PQE N +C+ R ++CDG +DC G DE C C E
Sbjct: 111 CGPQEAACRNG--HCIPRDYLCDGQEDCEDGSDELDCGPPPPCEPNE 155
Score = 34.7 bits (76), Expect = 3.1
Identities = 16/43 (37%), Positives = 21/43 (48%), Gaps = 1/43 (2%)
Query: 340 PNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCE 381
P R C+ E+ C CV + CD DC + DE+NCE
Sbjct: 19 PQFPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCE 61
>AB111888-1|BAC98376.1| 1322|Homo sapiens KIAA2036 protein protein.
Length = 1322
Score = 93.9 bits (223), Expect = 5e-18
Identities = 46/115 (40%), Positives = 55/115 (47%), Gaps = 7/115 (6%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C E C + C+P CD +DCGD TDE S P C G C DG+C+P
Sbjct: 302 CGEGQMTCSSGHCLPLALLCDRQDDCGDGTDEPSYP-----CPQGLLACADGRCLPPALL 356
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDE 377
CD DC D DE +C C E +C D C+ LCDGV DC +G DE
Sbjct: 357 CDGHPDCLDAADEESCLGQV--TCVPGEVSCVDGTCLGAIQLCDGVWDCPDGADE 409
Score = 87.0 bits (206), Expect = 5e-16
Identities = 56/160 (35%), Positives = 73/160 (45%), Gaps = 23/160 (14%)
Query: 269 ECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND-GKCIPERWRCDNER 327
+C N C + C GD G +E +VP +C GE C + G C+P W CDN+
Sbjct: 235 DCGNCTCQEGQWHCGGD---GGHCEE----LVP-ACAEGEALCQENGHCVPHGWLCDNQD 286
Query: 328 DCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEED 387
DC DG DE C + C + TC+ C+ LCD DC +G D E
Sbjct: 287 DCGDGSDEEGC---AAPGCGEGQMTCSSGHCLPLALLCDRQDDCGDGTD---------EP 334
Query: 388 QYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC 427
Y C PQ L++ A C+ +CDG DC DEE C
Sbjct: 335 SYPC-PQ-GLLACADGRCLPPALLCDGHPDCLDAADEESC 372
Score = 76.2 bits (179), Expect = 1e-12
Identities = 39/90 (43%), Positives = 44/90 (48%), Gaps = 9/90 (10%)
Query: 293 DEDSCPMVPGS----CNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSL 348
D S P+ S C EF+C G+C P WRCD E DCADG DE C C+
Sbjct: 436 DTASSPLASASPAPPCGPFEFRCGSGECTPRGWRCDQEEDCADGSDERGCG----GPCAP 491
Query: 349 DEYTCA-DRRCVLKTWLCDGVRDCTNGEDE 377
CA CV LCDGVR C +G DE
Sbjct: 492 HHAPCARGPHCVSPEQLCDGVRQCPDGSDE 521
Score = 70.1 bits (164), Expect = 7e-11
Identities = 66/263 (25%), Positives = 90/263 (34%), Gaps = 45/263 (17%)
Query: 162 ENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPT 221
E + C S + C+ L LCD +DCGD +DE + P L D P
Sbjct: 304 EGQMTCSSGH-CLPLALLCDRQDDCGDGTDEPS---------YPCPQGLLACADGRCLPP 353
Query: 222 VLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQ 281
L+ P + +AA+ S Q + C + C + C+
Sbjct: 354 ALLCDGHPDCL-------------DAADEESCLGQ----VTCVPGEVSCVDGTCLGAIQL 396
Query: 282 CDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPN 341
CDG DC D DE PG C +P D +
Sbjct: 397 CDGVWDCPDGADEG-----PGHCPLPSLPTPPASTLP-----GPSPGSLDTASSPLASAS 446
Query: 342 SIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNA 401
C E+ C C + W CD DC +G DE C C C H
Sbjct: 447 PAPPCGPFEFRCGSGECTPRGWRCDQEEDCADGSDERGCGGPCAPHHAPCARGPH----- 501
Query: 402 FRNCVNRKHVCDGMKDCPRGDDE 424
CV+ + +CDG++ CP G DE
Sbjct: 502 ---CVSPEQLCDGVRQCPDGSDE 521
Score = 68.9 bits (161), Expect = 2e-10
Identities = 53/174 (30%), Positives = 70/174 (40%), Gaps = 28/174 (16%)
Query: 162 ENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPT 221
E +C C+ WLCD +DCGD SDE C A G + +
Sbjct: 264 EGEALCQENGHCVPHGWLCDNQDDCGDGSDEEGC-----------AAPGCGEGQMTCSSG 312
Query: 222 VLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQ 281
+ L ++ + C D P ++ P L+ CA D C +P
Sbjct: 313 HCLPL---ALLCDRQDDCG----DGTDEP--SYPCPQGLLACA--DGRC-----LPPALL 356
Query: 282 CDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDE 335
CDG DC D DE+SC + +C GE C DG C+ CD DC DG DE
Sbjct: 357 CDGHPDCLDAADEESC-LGQVTCVPGEVSCVDGTCLGAIQLCDGVWDCPDGADE 409
Score = 60.9 bits (141), Expect = 4e-08
Identities = 52/184 (28%), Positives = 71/184 (38%), Gaps = 29/184 (15%)
Query: 311 CNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADR-RCVLKTWLCDGVR 369
C + C +W C GGD +C+ + C+ E C + CV WLCD
Sbjct: 236 CGNCTCQEGQWHC--------GGDGGHCE-ELVPACAEGEALCQENGHCVPHGWLCDNQD 286
Query: 370 DCTNGEDEMNCEV-SCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEER-- 426
DC +G DE C C E Q TC + +C+ +CD DC G DE
Sbjct: 287 DCGDGSDEEGCAAPGCGEGQMTC---------SSGHCLPLALLCDRQDDCGDGTDEPSYP 337
Query: 427 CPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTC 486
CP A+ +C + DGH C L A D+ SC C+ + TC
Sbjct: 338 CPQGLLACADGRCLPPALLC-DGHPDC------LDAADEESCLGQVTCVPGEVSCVDGTC 390
Query: 487 SNTV 490
+
Sbjct: 391 LGAI 394
Score = 59.3 bits (137), Expect = 1e-07
Identities = 63/278 (22%), Positives = 106/278 (38%), Gaps = 29/278 (10%)
Query: 173 CIALEWLCDGDNDCGDFSDE------INCDVVKTSLLVPSANASLNIGDVITN------- 219
C+ LCDG DC D +DE + C + S + + ++ + D + +
Sbjct: 350 CLPPALLCDGHPDCLDAADEESCLGQVTCVPGEVSCVDGTCLGAIQLCDGVWDCPDGADE 409
Query: 220 -PTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPK 278
P + PT + +LD A++P ++ + C +F C + +C P+
Sbjct: 410 GPGHCPLPSLPTPPASTLPGPSPGSLDTASSPLASASPAPP---CGPFEFRCGSGECTPR 466
Query: 279 DFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK-CIPERWRCDNERDC---ADGGD 334
++CD + DC D +DE C G C C G C+ CD R C +D G
Sbjct: 467 GWRCDQEEDCADGSDERGCG---GPCAPHHAPCARGPHCVSPEQLCDGVRQCPDGSDEGP 523
Query: 335 ELNCK---PNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCE--VSCEEDQY 389
+ + P ++R R + + G++ V Q
Sbjct: 524 DACVEAPAPPAMRGPPGQAGGPTSSRAPSPPSPPEAQGEGRKGQERSRTHLTVPAGSTQL 583
Query: 390 TCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC 427
P A C+ + +CDG+ DCP+G+DE C
Sbjct: 584 PLCPGLFPCGVAPGLCLTPEQLCDGIPDCPQGEDELDC 621
>BC113716-1|AAI13717.1| 713|Homo sapiens low density lipoprotein
receptor-related protein 10 protein.
Length = 713
Score = 89.8 bits (213), Expect = 8e-17
Identities = 43/113 (38%), Positives = 56/113 (49%), Gaps = 15/113 (13%)
Query: 274 KCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDG------KCIPERWRCDNER 327
+C + +CDG DC D TDE+ CP C G F C C RC+ +
Sbjct: 330 RCYSEAQRCDGSWDCADGTDEEDCP----GCPPGHFPCGAAGTSGATACYLPADRCNYQT 385
Query: 328 DCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC 380
CADG DE C R+C + C D +CV +TW+CDG DC +G DE +C
Sbjct: 386 FCADGADERRC-----RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
Score = 62.5 bits (145), Expect = 1e-08
Identities = 29/67 (43%), Positives = 36/67 (53%), Gaps = 6/67 (8%)
Query: 273 TKC-VPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCAD 331
T C +P D +C+ C D DE C C G F+C D KC+ E W CD + DCAD
Sbjct: 372 TACYLPAD-RCNYQTFCADGADERRCR----HCQPGNFRCRDEKCVYETWVCDGQPDCAD 426
Query: 332 GGDELNC 338
G DE +C
Sbjct: 427 GSDEWDC 433
Score = 62.1 bits (144), Expect = 2e-08
Identities = 39/115 (33%), Positives = 47/115 (40%), Gaps = 13/115 (11%)
Query: 315 KCIPERWRCDNERDCADGGDELNCK--PNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCT 372
+C E RCD DCADG DE +C P C T C L C+ C
Sbjct: 330 RCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAG-TSGATACYLPADRCNYQTFCA 388
Query: 373 NGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC 427
+G DE C C+ + CR ++ CV VCDG DC G DE C
Sbjct: 389 DGADERRCR-HCQPGNFRCRDEK---------CVYETWVCDGQPDCADGSDEWDC 433
Score = 44.4 bits (100), Expect = 0.004
Identities = 39/128 (30%), Positives = 52/128 (40%), Gaps = 22/128 (17%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
C + CDG DC D +DE +C P + G T+ L P
Sbjct: 331 CYSEAQRCDGSWDCADGTDEEDCPGC------PPGH--FPCGAAGTSGATACYL--PADR 380
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWT 292
Y++FCA D A R QP +F C++ KCV + + CDG DC D +
Sbjct: 381 CNYQTFCA----DGADERRCRHCQPG--------NFRCRDEKCVYETWVCDGQPDCADGS 428
Query: 293 DEDSCPMV 300
DE C V
Sbjct: 429 DEWDCSYV 436
Score = 41.9 bits (94), Expect = 0.020
Identities = 16/41 (39%), Positives = 24/41 (58%)
Query: 261 MRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVP 301
+ C + +F+C N +CV +CDG + CGD +DE C P
Sbjct: 138 LMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDP 178
Score = 39.5 bits (88), Expect = 0.11
Identities = 15/35 (42%), Positives = 19/35 (54%)
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC 380
C +E+ C + RCV CDGV C +G DE C
Sbjct: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
Score = 38.3 bits (85), Expect = 0.25
Identities = 19/54 (35%), Positives = 29/54 (53%), Gaps = 4/54 (7%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIAL 226
C+ W+CDG DC D SDE +C V ++ +A IG ++ ++IAL
Sbjct: 411 CVYETWVCDGQPDCADGSDEWDCSYVLPRKVITAA----VIGSLVCGLLLVIAL 460
Score = 36.7 bits (81), Expect = 0.76
Identities = 14/35 (40%), Positives = 18/35 (51%)
Query: 304 CNAGEFKCNDGKCIPERWRCDNERDCADGGDELNC 338
C EF+C + +C+ RCD C DG DE C
Sbjct: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
>BC113714-1|AAI13715.1| 713|Homo sapiens low density lipoprotein
receptor-related protein 10 protein.
Length = 713
Score = 89.8 bits (213), Expect = 8e-17
Identities = 43/113 (38%), Positives = 56/113 (49%), Gaps = 15/113 (13%)
Query: 274 KCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDG------KCIPERWRCDNER 327
+C + +CDG DC D TDE+ CP C G F C C RC+ +
Sbjct: 330 RCYSEAQRCDGSWDCADGTDEEDCP----GCPPGHFPCGAAGTSGATACYLPADRCNYQT 385
Query: 328 DCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC 380
CADG DE C R+C + C D +CV +TW+CDG DC +G DE +C
Sbjct: 386 FCADGADERRC-----RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
Score = 62.5 bits (145), Expect = 1e-08
Identities = 29/67 (43%), Positives = 36/67 (53%), Gaps = 6/67 (8%)
Query: 273 TKC-VPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCAD 331
T C +P D +C+ C D DE C C G F+C D KC+ E W CD + DCAD
Sbjct: 372 TACYLPAD-RCNYQTFCADGADERRCR----HCQPGNFRCRDEKCVYETWVCDGQPDCAD 426
Query: 332 GGDELNC 338
G DE +C
Sbjct: 427 GSDEWDC 433
Score = 62.1 bits (144), Expect = 2e-08
Identities = 39/115 (33%), Positives = 47/115 (40%), Gaps = 13/115 (11%)
Query: 315 KCIPERWRCDNERDCADGGDELNCK--PNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCT 372
+C E RCD DCADG DE +C P C T C L C+ C
Sbjct: 330 RCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAG-TSGATACYLPADRCNYQTFCA 388
Query: 373 NGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC 427
+G DE C C+ + CR ++ CV VCDG DC G DE C
Sbjct: 389 DGADERRCR-HCQPGNFRCRDEK---------CVYETWVCDGQPDCADGSDEWDC 433
Score = 44.4 bits (100), Expect = 0.004
Identities = 39/128 (30%), Positives = 52/128 (40%), Gaps = 22/128 (17%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
C + CDG DC D +DE +C P + G T+ L P
Sbjct: 331 CYSEAQRCDGSWDCADGTDEEDCPGC------PPGH--FPCGAAGTSGATACYL--PADR 380
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWT 292
Y++FCA D A R QP +F C++ KCV + + CDG DC D +
Sbjct: 381 CNYQTFCA----DGADERRCRHCQPG--------NFRCRDEKCVYETWVCDGQPDCADGS 428
Query: 293 DEDSCPMV 300
DE C V
Sbjct: 429 DEWDCSYV 436
Score = 41.9 bits (94), Expect = 0.020
Identities = 16/41 (39%), Positives = 24/41 (58%)
Query: 261 MRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVP 301
+ C + +F+C N +CV +CDG + CGD +DE C P
Sbjct: 138 LMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDP 178
Score = 39.5 bits (88), Expect = 0.11
Identities = 15/35 (42%), Positives = 19/35 (54%)
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC 380
C +E+ C + RCV CDGV C +G DE C
Sbjct: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
Score = 38.3 bits (85), Expect = 0.25
Identities = 19/54 (35%), Positives = 29/54 (53%), Gaps = 4/54 (7%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIAL 226
C+ W+CDG DC D SDE +C V ++ +A IG ++ ++IAL
Sbjct: 411 CVYETWVCDGQPDCADGSDEWDCSYVLPRKVITAA----VIGSLVCGLLLVIAL 460
Score = 36.7 bits (81), Expect = 0.76
Identities = 14/35 (40%), Positives = 18/35 (51%)
Query: 304 CNAGEFKCNDGKCIPERWRCDNERDCADGGDELNC 338
C EF+C + +C+ RCD C DG DE C
Sbjct: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
>BC064901-1|AAH64901.1| 457|Homo sapiens LRP10 protein protein.
Length = 457
Score = 89.8 bits (213), Expect = 8e-17
Identities = 43/113 (38%), Positives = 56/113 (49%), Gaps = 15/113 (13%)
Query: 274 KCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDG------KCIPERWRCDNER 327
+C + +CDG DC D TDE+ CP C G F C C RC+ +
Sbjct: 231 RCYSEAQRCDGSWDCADGTDEEDCP----GCPPGHFPCGAAGTSGATACYLPADRCNYQT 286
Query: 328 DCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC 380
CADG DE C R+C + C D +CV +TW+CDG DC +G DE +C
Sbjct: 287 FCADGADERRC-----RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 334
Score = 62.5 bits (145), Expect = 1e-08
Identities = 29/67 (43%), Positives = 36/67 (53%), Gaps = 6/67 (8%)
Query: 273 TKC-VPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCAD 331
T C +P D +C+ C D DE C C G F+C D KC+ E W CD + DCAD
Sbjct: 273 TACYLPAD-RCNYQTFCADGADERRCR----HCQPGNFRCRDEKCVYETWVCDGQPDCAD 327
Query: 332 GGDELNC 338
G DE +C
Sbjct: 328 GSDEWDC 334
Score = 62.1 bits (144), Expect = 2e-08
Identities = 39/115 (33%), Positives = 47/115 (40%), Gaps = 13/115 (11%)
Query: 315 KCIPERWRCDNERDCADGGDELNCK--PNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCT 372
+C E RCD DCADG DE +C P C T C L C+ C
Sbjct: 231 RCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAG-TSGATACYLPADRCNYQTFCA 289
Query: 373 NGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC 427
+G DE C C+ + CR ++ CV VCDG DC G DE C
Sbjct: 290 DGADERRCR-HCQPGNFRCRDEK---------CVYETWVCDGQPDCADGSDEWDC 334
Score = 44.4 bits (100), Expect = 0.004
Identities = 39/128 (30%), Positives = 52/128 (40%), Gaps = 22/128 (17%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
C + CDG DC D +DE +C P + G T+ L P
Sbjct: 232 CYSEAQRCDGSWDCADGTDEEDCPGC------PPGH--FPCGAAGTSGATACYL--PADR 281
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWT 292
Y++FCA D A R QP +F C++ KCV + + CDG DC D +
Sbjct: 282 CNYQTFCA----DGADERRCRHCQPG--------NFRCRDEKCVYETWVCDGQPDCADGS 329
Query: 293 DEDSCPMV 300
DE C V
Sbjct: 330 DEWDCSYV 337
Score = 41.9 bits (94), Expect = 0.020
Identities = 16/41 (39%), Positives = 24/41 (58%)
Query: 261 MRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVP 301
+ C + +F+C N +CV +CDG + CGD +DE C P
Sbjct: 39 LMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDP 79
Score = 39.5 bits (88), Expect = 0.11
Identities = 15/35 (42%), Positives = 19/35 (54%)
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC 380
C +E+ C + RCV CDGV C +G DE C
Sbjct: 41 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 75
Score = 38.3 bits (85), Expect = 0.25
Identities = 19/54 (35%), Positives = 29/54 (53%), Gaps = 4/54 (7%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIAL 226
C+ W+CDG DC D SDE +C V ++ +A IG ++ ++IAL
Sbjct: 312 CVYETWVCDGQPDCADGSDEWDCSYVLPRKVITAA----VIGSLVCGLLLVIAL 361
Score = 36.7 bits (81), Expect = 0.76
Identities = 14/35 (40%), Positives = 18/35 (51%)
Query: 304 CNAGEFKCNDGKCIPERWRCDNERDCADGGDELNC 338
C EF+C + +C+ RCD C DG DE C
Sbjct: 41 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 75
>AY358399-1|AAQ88765.1| 713|Homo sapiens LRP10 protein.
Length = 713
Score = 89.8 bits (213), Expect = 8e-17
Identities = 43/113 (38%), Positives = 56/113 (49%), Gaps = 15/113 (13%)
Query: 274 KCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDG------KCIPERWRCDNER 327
+C + +CDG DC D TDE+ CP C G F C C RC+ +
Sbjct: 330 RCYSEAQRCDGSWDCADGTDEEDCP----GCPPGHFPCGAAGTSGATACYLPADRCNYQT 385
Query: 328 DCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC 380
CADG DE C R+C + C D +CV +TW+CDG DC +G DE +C
Sbjct: 386 FCADGADERRC-----RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
Score = 62.5 bits (145), Expect = 1e-08
Identities = 29/67 (43%), Positives = 36/67 (53%), Gaps = 6/67 (8%)
Query: 273 TKC-VPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCAD 331
T C +P D +C+ C D DE C C G F+C D KC+ E W CD + DCAD
Sbjct: 372 TACYLPAD-RCNYQTFCADGADERRCR----HCQPGNFRCRDEKCVYETWVCDGQPDCAD 426
Query: 332 GGDELNC 338
G DE +C
Sbjct: 427 GSDEWDC 433
Score = 62.1 bits (144), Expect = 2e-08
Identities = 39/115 (33%), Positives = 47/115 (40%), Gaps = 13/115 (11%)
Query: 315 KCIPERWRCDNERDCADGGDELNCK--PNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCT 372
+C E RCD DCADG DE +C P C T C L C+ C
Sbjct: 330 RCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAG-TSGATACYLPADRCNYQTFCA 388
Query: 373 NGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC 427
+G DE C C+ + CR ++ CV VCDG DC G DE C
Sbjct: 389 DGADERRCR-HCQPGNFRCRDEK---------CVYETWVCDGQPDCADGSDEWDC 433
Score = 44.4 bits (100), Expect = 0.004
Identities = 39/128 (30%), Positives = 52/128 (40%), Gaps = 22/128 (17%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVV 232
C + CDG DC D +DE +C P + G T+ L P
Sbjct: 331 CYSEAQRCDGSWDCADGTDEEDCPGC------PPGH--FPCGAAGTSGATACYL--PADR 380
Query: 233 IRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWT 292
Y++FCA D A R QP +F C++ KCV + + CDG DC D +
Sbjct: 381 CNYQTFCA----DGADERRCRHCQPG--------NFRCRDEKCVYETWVCDGQPDCADGS 428
Query: 293 DEDSCPMV 300
DE C V
Sbjct: 429 DEWDCSYV 436
Score = 41.9 bits (94), Expect = 0.020
Identities = 16/41 (39%), Positives = 24/41 (58%)
Query: 261 MRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVP 301
+ C + +F+C N +CV +CDG + CGD +DE C P
Sbjct: 138 LMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDP 178
Score = 39.5 bits (88), Expect = 0.11
Identities = 15/35 (42%), Positives = 19/35 (54%)
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC 380
C +E+ C + RCV CDGV C +G DE C
Sbjct: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
Score = 38.3 bits (85), Expect = 0.25
Identities = 19/54 (35%), Positives = 29/54 (53%), Gaps = 4/54 (7%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIAL 226
C+ W+CDG DC D SDE +C V ++ +A IG ++ ++IAL
Sbjct: 411 CVYETWVCDGQPDCADGSDEWDCSYVLPRKVITAA----VIGSLVCGLLLVIAL 460
Score = 36.7 bits (81), Expect = 0.76
Identities = 14/35 (40%), Positives = 18/35 (51%)
Query: 304 CNAGEFKCNDGKCIPERWRCDNERDCADGGDELNC 338
C EF+C + +C+ RCD C DG DE C
Sbjct: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
>BC088378-1|AAH88378.1| 377|Homo sapiens LRP10 protein protein.
Length = 377
Score = 87.8 bits (208), Expect = 3e-16
Identities = 42/106 (39%), Positives = 53/106 (50%), Gaps = 15/106 (14%)
Query: 281 QCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDG------KCIPERWRCDNERDCADGGD 334
+CDG DC D TDE+ CP C G F C C RC+ + CADG D
Sbjct: 1 RCDGSWDCADGTDEEDCP----GCPPGHFPCGAAGTSGATACYLPADRCNYQTFCADGAD 56
Query: 335 ELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC 380
E C R+C + C D +CV +TW+CDG DC +G DE +C
Sbjct: 57 ERRC-----RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 97
Score = 62.5 bits (145), Expect = 1e-08
Identities = 29/67 (43%), Positives = 36/67 (53%), Gaps = 6/67 (8%)
Query: 273 TKC-VPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCAD 331
T C +P D +C+ C D DE C C G F+C D KC+ E W CD + DCAD
Sbjct: 36 TACYLPAD-RCNYQTFCADGADERRCR----HCQPGNFRCRDEKCVYETWVCDGQPDCAD 90
Query: 332 GGDELNC 338
G DE +C
Sbjct: 91 GSDEWDC 97
Score = 57.6 bits (133), Expect = 4e-07
Identities = 37/108 (34%), Positives = 44/108 (40%), Gaps = 13/108 (12%)
Query: 322 RCDNERDCADGGDELNCK--PNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMN 379
RCD DCADG DE +C P C T C L C+ C +G DE
Sbjct: 1 RCDGSWDCADGTDEEDCPGCPPGHFPCGAAG-TSGATACYLPADRCNYQTFCADGADERR 59
Query: 380 CEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC 427
C C+ + CR ++ CV VCDG DC G DE C
Sbjct: 60 CR-HCQPGNFRCRDEK---------CVYETWVCDGQPDCADGSDEWDC 97
Score = 44.0 bits (99), Expect = 0.005
Identities = 38/121 (31%), Positives = 50/121 (41%), Gaps = 22/121 (18%)
Query: 180 CDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIALTKPTVVIRYESFC 239
CDG DC D +DE +C P + G T+ L P Y++FC
Sbjct: 2 CDGSWDCADGTDEEDCPGC------PPGH--FPCGAAGTSGATACYL--PADRCNYQTFC 51
Query: 240 AKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPM 299
A D A R QP +F C++ KCV + + CDG DC D +DE C
Sbjct: 52 A----DGADERRCRHCQPG--------NFRCRDEKCVYETWVCDGQPDCADGSDEWDCSY 99
Query: 300 V 300
V
Sbjct: 100 V 100
Score = 38.3 bits (85), Expect = 0.25
Identities = 19/54 (35%), Positives = 29/54 (53%), Gaps = 4/54 (7%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIAL 226
C+ W+CDG DC D SDE +C V ++ +A IG ++ ++IAL
Sbjct: 75 CVYETWVCDGQPDCADGSDEWDCSYVLPRKVITAA----VIGSLVCGLLLVIAL 124
>U94333-1|AAB53110.1| 652|Homo sapiens C1qR(p) protein.
Length = 652
Score = 85.8 bits (203), Expect = 1e-15
Identities = 64/199 (32%), Positives = 86/199 (43%), Gaps = 19/199 (9%)
Query: 327 RDCADGGDE---LNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVS 383
+DC +GGD C+P R D TCA R + C G C G N
Sbjct: 273 QDCFEGGDGSFLCGCRPG-FRLLD-DLVTCASRNPCSSS-PCRGGATCVLGPHGKNYTCR 329
Query: 384 C------EEDQYTCRPQEHLM-SNAFRNCVNRK--HVCDGMKDC-PRGDDEERCPLKRKC 433
C + Q C + S + CVN C+ P G E C +C
Sbjct: 330 CPQGYQLDSSQLDCVDVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDEC 389
Query: 434 S-AEEKCEKLCITTYDGHAACACPMGFLLA-EDKYSCRDIDECMYEQDPVCSQTCSNTVG 491
+ C + C T DG C+C G++LA ED C+D+DEC+ P+C C NT G
Sbjct: 390 ALGRSPCAQGCTNT-DGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQG 448
Query: 492 SFRCGCMTGYILRPDERSC 510
SF CGC+ G++L P+ SC
Sbjct: 449 SFHCGCLPGWVLAPNGVSC 467
Score = 34.7 bits (76), Expect = 3.1
Identities = 22/81 (27%), Positives = 31/81 (38%), Gaps = 7/81 (8%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVG----SFR 494
C + C DG C C GF L +D +C + C P C + +G ++
Sbjct: 271 CHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPC--SSSP-CRGGATCVLGPHGKNYT 327
Query: 495 CGCMTGYILRPDERSCKPTGE 515
C C GY L + C E
Sbjct: 328 CRCPQGYQLDSSQLDCVDVDE 348
Score = 33.1 bits (72), Expect = 9.3
Identities = 17/39 (43%), Positives = 18/39 (46%), Gaps = 1/39 (2%)
Query: 1018 GCGKNNGGCSHLCLL-KPGGRSCACPIGIKLNKDGKTCA 1055
GC NNGGC C G C C G +L D TCA
Sbjct: 263 GCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCA 301
>BC117322-1|AAI17323.1| 572|Homo sapiens TMPRSS7 protein protein.
Length = 572
Score = 85.8 bits (203), Expect = 1e-15
Identities = 53/135 (39%), Positives = 62/135 (45%), Gaps = 19/135 (14%)
Query: 304 CNAGEFKCNDGKCIPERWRCDNERDCADGGDELNC-KPNSIRNCSLDEYTCADRRCVLKT 362
C G F+C+ G C+P+ RCD DC D DEL C P N T + R+
Sbjct: 213 CPVGSFRCSSGLCVPQAQRCDGVNDCFDESDELFCVSPQPACN------TSSFRQ--HGP 264
Query: 363 WLCDGVRDCTNGEDEMNC--EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPR 420
+CDG RDC NG DE NC + C + C FR N K CDG DCP
Sbjct: 265 LICDGFRDCENGRDEQNCTQSIPCNNRTFKCG-----NDICFRK-QNAK--CDGTVDCPD 316
Query: 421 GDDEERCPLKRKCSA 435
G DEE C R SA
Sbjct: 317 GSDEEGCTCSRSSSA 331
Score = 79.0 bits (186), Expect = 1e-13
Identities = 47/122 (38%), Positives = 58/122 (47%), Gaps = 9/122 (7%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C F C + CVP+ +CDG NDC D +DE C +CN F+ G I
Sbjct: 213 CPVGSFRCSSGLCVPQAQRCDGVNDCFDESDELFCVSPQPACNTSSFR-QHGPLI----- 266
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLK-TWLCDGVRDCTNGEDEMNCE 381
CD RDC +G DE NC SI C+ + C + C K CDG DC +G DE C
Sbjct: 267 CDGFRDCENGRDEQNC-TQSI-PCNNRTFKCGNDICFRKQNAKCDGTVDCPDGSDEEGCT 324
Query: 382 VS 383
S
Sbjct: 325 CS 326
Score = 52.8 bits (121), Expect = 1e-05
Identities = 30/94 (31%), Positives = 45/94 (47%), Gaps = 12/94 (12%)
Query: 341 NSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSN 400
N + C + + C+ CV + CDGV DC + DE+ C VS PQ ++
Sbjct: 208 NISQPCPVGSFRCSSGLCVPQAQRCDGVNDCFDESDELFC-VS---------PQPACNTS 257
Query: 401 AFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCS 434
+FR + +CDG +DC G DE+ C C+
Sbjct: 258 SFRQ--HGPLICDGFRDCENGRDEQNCTQSIPCN 289
Score = 33.1 bits (72), Expect = 9.3
Identities = 13/27 (48%), Positives = 17/27 (62%)
Query: 169 STNVCIALEWLCDGDNDCGDFSDEINC 195
S+ +C+ CDG NDC D SDE+ C
Sbjct: 221 SSGLCVPQAQRCDGVNDCFDESDELFC 247
>BC028075-1|AAH28075.1| 652|Homo sapiens CD93 molecule protein.
Length = 652
Score = 85.8 bits (203), Expect = 1e-15
Identities = 64/199 (32%), Positives = 86/199 (43%), Gaps = 19/199 (9%)
Query: 327 RDCADGGDE---LNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVS 383
+DC +GGD C+P R D TCA R + C G C G N
Sbjct: 273 QDCFEGGDGSFLCGCRPG-FRLLD-DLVTCASRNPCSSS-PCRGGATCVLGPHGKNYTCR 329
Query: 384 C------EEDQYTCRPQEHLM-SNAFRNCVNRK--HVCDGMKDC-PRGDDEERCPLKRKC 433
C + Q C + S + CVN C+ P G E C +C
Sbjct: 330 CPQGYQLDSSQLDCVDVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDEC 389
Query: 434 S-AEEKCEKLCITTYDGHAACACPMGFLLA-EDKYSCRDIDECMYEQDPVCSQTCSNTVG 491
+ C + C T DG C+C G++LA ED C+D+DEC+ P+C C NT G
Sbjct: 390 ALGRSPCAQGCTNT-DGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQG 448
Query: 492 SFRCGCMTGYILRPDERSC 510
SF CGC+ G++L P+ SC
Sbjct: 449 SFHCGCLPGWVLAPNGVSC 467
Score = 34.7 bits (76), Expect = 3.1
Identities = 22/81 (27%), Positives = 31/81 (38%), Gaps = 7/81 (8%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVG----SFR 494
C + C DG C C GF L +D +C + C P C + +G ++
Sbjct: 271 CHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPC--SSSP-CRGGATCVLGPHGKNYT 327
Query: 495 CGCMTGYILRPDERSCKPTGE 515
C C GY L + C E
Sbjct: 328 CRCPQGYQLDSSQLDCVDVDE 348
Score = 33.1 bits (72), Expect = 9.3
Identities = 17/39 (43%), Positives = 18/39 (46%), Gaps = 1/39 (2%)
Query: 1018 GCGKNNGGCSHLCLL-KPGGRSCACPIGIKLNKDGKTCA 1055
GC NNGGC C G C C G +L D TCA
Sbjct: 263 GCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCA 301
>AL118508-1|CAC00597.1| 652|Homo sapiens complement component 1, q
subcomponent, receptor 1 protein.
Length = 652
Score = 85.8 bits (203), Expect = 1e-15
Identities = 64/199 (32%), Positives = 86/199 (43%), Gaps = 19/199 (9%)
Query: 327 RDCADGGDE---LNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVS 383
+DC +GGD C+P R D TCA R + C G C G N
Sbjct: 273 QDCFEGGDGSFLCGCRPG-FRLLD-DLVTCASRNPCSSS-PCRGGATCVLGPHGKNYTCR 329
Query: 384 C------EEDQYTCRPQEHLM-SNAFRNCVNRK--HVCDGMKDC-PRGDDEERCPLKRKC 433
C + Q C + S + CVN C+ P G E C +C
Sbjct: 330 CPQGYQLDSSQLDCVDVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDEC 389
Query: 434 S-AEEKCEKLCITTYDGHAACACPMGFLLA-EDKYSCRDIDECMYEQDPVCSQTCSNTVG 491
+ C + C T DG C+C G++LA ED C+D+DEC+ P+C C NT G
Sbjct: 390 ALGRSPCAQGCTNT-DGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQG 448
Query: 492 SFRCGCMTGYILRPDERSC 510
SF CGC+ G++L P+ SC
Sbjct: 449 SFHCGCLPGWVLAPNGVSC 467
Score = 34.7 bits (76), Expect = 3.1
Identities = 22/81 (27%), Positives = 31/81 (38%), Gaps = 7/81 (8%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVG----SFR 494
C + C DG C C GF L +D +C + C P C + +G ++
Sbjct: 271 CHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPC--SSSP-CRGGATCVLGPHGKNYT 327
Query: 495 CGCMTGYILRPDERSCKPTGE 515
C C GY L + C E
Sbjct: 328 CRCPQGYQLDSSQLDCVDVDE 348
Score = 33.1 bits (72), Expect = 9.3
Identities = 17/39 (43%), Positives = 18/39 (46%), Gaps = 1/39 (2%)
Query: 1018 GCGKNNGGCSHLCLL-KPGGRSCACPIGIKLNKDGKTCA 1055
GC NNGGC C G C C G +L D TCA
Sbjct: 263 GCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCA 301
>AK131211-1|BAD18401.1| 572|Homo sapiens protein ( Homo sapiens
cDNA FLJ16088 fis, clone NT2RP7008435, weakly similar
to EPITHIN (EC 3.4.21.-). ).
Length = 572
Score = 85.8 bits (203), Expect = 1e-15
Identities = 53/135 (39%), Positives = 62/135 (45%), Gaps = 19/135 (14%)
Query: 304 CNAGEFKCNDGKCIPERWRCDNERDCADGGDELNC-KPNSIRNCSLDEYTCADRRCVLKT 362
C G F+C+ G C+P+ RCD DC D DEL C P N T + R+
Sbjct: 213 CPVGSFRCSSGLCVPQAQRCDGVNDCFDESDELFCVSPQPACN------TSSFRQ--HGP 264
Query: 363 WLCDGVRDCTNGEDEMNC--EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPR 420
+CDG RDC NG DE NC + C + C FR N K CDG DCP
Sbjct: 265 LICDGFRDCENGRDEQNCTQSIPCNNRTFKCG-----NDICFRK-QNAK--CDGTVDCPD 316
Query: 421 GDDEERCPLKRKCSA 435
G DEE C R SA
Sbjct: 317 GSDEEGCTCSRSSSA 331
Score = 79.0 bits (186), Expect = 1e-13
Identities = 47/122 (38%), Positives = 58/122 (47%), Gaps = 9/122 (7%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C F C + CVP+ +CDG NDC D +DE C +CN F+ G I
Sbjct: 213 CPVGSFRCSSGLCVPQAQRCDGVNDCFDESDELFCVSPQPACNTSSFR-QHGPLI----- 266
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLK-TWLCDGVRDCTNGEDEMNCE 381
CD RDC +G DE NC SI C+ + C + C K CDG DC +G DE C
Sbjct: 267 CDGFRDCENGRDEQNC-TQSI-PCNNRTFKCGNDICFRKQNAKCDGTVDCPDGSDEEGCT 324
Query: 382 VS 383
S
Sbjct: 325 CS 326
Score = 52.8 bits (121), Expect = 1e-05
Identities = 30/94 (31%), Positives = 45/94 (47%), Gaps = 12/94 (12%)
Query: 341 NSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSN 400
N + C + + C+ CV + CDGV DC + DE+ C VS PQ ++
Sbjct: 208 NISQPCPVGSFRCSSGLCVPQAQRCDGVNDCFDESDELFC-VS---------PQPACNTS 257
Query: 401 AFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCS 434
+FR + +CDG +DC G DE+ C C+
Sbjct: 258 SFRQ--HGPLICDGFRDCENGRDEQNCTQSIPCN 289
Score = 33.1 bits (72), Expect = 9.3
Identities = 13/27 (48%), Positives = 17/27 (62%)
Query: 169 STNVCIALEWLCDGDNDCGDFSDEINC 195
S+ +C+ CDG NDC D SDE+ C
Sbjct: 221 SSGLCVPQAQRCDGVNDCFDESDELFC 247
>AJ295142-1|CAC82720.1| 652|Homo sapiens C1q receptor protein
protein.
Length = 652
Score = 85.8 bits (203), Expect = 1e-15
Identities = 64/199 (32%), Positives = 86/199 (43%), Gaps = 19/199 (9%)
Query: 327 RDCADGGDE---LNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVS 383
+DC +GGD C+P R D TCA R + C G C G N
Sbjct: 273 QDCFEGGDGSFLCGCRPG-FRLLD-DLVTCASRNPCSSS-PCRGGATCALGPHGKNYTCR 329
Query: 384 C------EEDQYTCRPQEHLM-SNAFRNCVNRK--HVCDGMKDC-PRGDDEERCPLKRKC 433
C + Q C + S + CVN C+ P G E C +C
Sbjct: 330 CPQGYQLDSSQLDCVDVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDEC 389
Query: 434 S-AEEKCEKLCITTYDGHAACACPMGFLLA-EDKYSCRDIDECMYEQDPVCSQTCSNTVG 491
+ C + C T DG C+C G++LA ED C+D+DEC+ P+C C NT G
Sbjct: 390 ALGRSPCAQGCTNT-DGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQG 448
Query: 492 SFRCGCMTGYILRPDERSC 510
SF CGC+ G++L P+ SC
Sbjct: 449 SFHCGCLPGWVLAPNGVSC 467
Score = 34.7 bits (76), Expect = 3.1
Identities = 22/81 (27%), Positives = 31/81 (38%), Gaps = 7/81 (8%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVG----SFR 494
C + C DG C C GF L +D +C + C P C + +G ++
Sbjct: 271 CHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPC--SSSP-CRGGATCALGPHGKNYT 327
Query: 495 CGCMTGYILRPDERSCKPTGE 515
C C GY L + C E
Sbjct: 328 CRCPQGYQLDSSQLDCVDVDE 348
Score = 33.1 bits (72), Expect = 9.3
Identities = 17/39 (43%), Positives = 18/39 (46%), Gaps = 1/39 (2%)
Query: 1018 GCGKNNGGCSHLCLL-KPGGRSCACPIGIKLNKDGKTCA 1055
GC NNGGC C G C C G +L D TCA
Sbjct: 263 GCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCA 301
>AB209895-1|BAD93132.1| 671|Homo sapiens complement component 1, q
subcomponent, receptor 1 variant protein.
Length = 671
Score = 85.8 bits (203), Expect = 1e-15
Identities = 64/199 (32%), Positives = 86/199 (43%), Gaps = 19/199 (9%)
Query: 327 RDCADGGDE---LNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVS 383
+DC +GGD C+P R D TCA R + C G C G N
Sbjct: 292 QDCFEGGDGSFLCGCRPG-FRLLD-DLVTCASRNPCSSS-PCRGGATCVLGPHGKNYTCR 348
Query: 384 C------EEDQYTCRPQEHLM-SNAFRNCVNRK--HVCDGMKDC-PRGDDEERCPLKRKC 433
C + Q C + S + CVN C+ P G E C +C
Sbjct: 349 CPQGYQLDSSQLDCVDVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDEC 408
Query: 434 S-AEEKCEKLCITTYDGHAACACPMGFLLA-EDKYSCRDIDECMYEQDPVCSQTCSNTVG 491
+ C + C T DG C+C G++LA ED C+D+DEC+ P+C C NT G
Sbjct: 409 ALGRSPCAQGCTNT-DGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQG 467
Query: 492 SFRCGCMTGYILRPDERSC 510
SF CGC+ G++L P+ SC
Sbjct: 468 SFHCGCLPGWVLAPNGVSC 486
Score = 34.7 bits (76), Expect = 3.1
Identities = 22/81 (27%), Positives = 31/81 (38%), Gaps = 7/81 (8%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVG----SFR 494
C + C DG C C GF L +D +C + C P C + +G ++
Sbjct: 290 CHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPC--SSSP-CRGGATCVLGPHGKNYT 346
Query: 495 CGCMTGYILRPDERSCKPTGE 515
C C GY L + C E
Sbjct: 347 CRCPQGYQLDSSQLDCVDVDE 367
Score = 33.1 bits (72), Expect = 9.3
Identities = 17/39 (43%), Positives = 18/39 (46%), Gaps = 1/39 (2%)
Query: 1018 GCGKNNGGCSHLCLL-KPGGRSCACPIGIKLNKDGKTCA 1055
GC NNGGC C G C C G +L D TCA
Sbjct: 282 GCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCA 320
>BC111690-1|AAI11691.1| 807|Homo sapiens SCUBE2 protein protein.
Length = 807
Score = 85.4 bits (202), Expect = 2e-15
Identities = 76/270 (28%), Positives = 115/270 (42%), Gaps = 37/270 (13%)
Query: 276 VPKDFQC---DG---DNDCGDWTDEDSCPMVPGSCN------AGEFKCNDGKCIPERWRC 323
+P +++C DG +D + D D C G C G ++C C +
Sbjct: 105 IPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECC---CKEGFFLS 161
Query: 324 DNERDCADGGDE-LNCKPNSIRNCS--LDEYTCADRRCVLKTW--LCDGVRDCT------ 372
DN+ C +E L+C N CS E C + L RDC
Sbjct: 162 DNQHTCIHRSEEGLSCM-NKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHG 220
Query: 373 NGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVC-----DGMKDCPRGDDE-ER 426
NG + +C+ + + + +C PQ + ++ R+C+ R+ GD +R
Sbjct: 221 NGGCQHSCDDTADGPECSCHPQYKMHTDG-RSCLEREDTVLEVTESNTTSVVDGDKRVKR 279
Query: 427 CPLKRKCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQT 485
L C+ C++ C T G C+CP+GF L D +C+DIDEC ++ C
Sbjct: 280 RLLMETCAVNNGGCDRTCKDTSTG-VHCSCPVGFTLQLDGKTCKDIDECQ-TRNGGCDHF 337
Query: 486 CSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C N VGSF CGC G+ L DE+SC+ E
Sbjct: 338 CKNIVGSFDCGCKKGFKLLTDEKSCQDVDE 367
Score = 65.3 bits (152), Expect = 2e-09
Identities = 33/88 (37%), Positives = 45/88 (51%), Gaps = 3/88 (3%)
Query: 423 DEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC 482
DE+ C +CS + C+ CI + G ACAC G+ L + C D +EC C
Sbjct: 358 DEKSCQDVDECSLDRTCDHSCIN-HPGTFACACNRGYTLYGFTH-CGDTNECSINNGG-C 414
Query: 483 SQTCSNTVGSFRCGCMTGYILRPDERSC 510
Q C NTVGS+ C C GY L +++ C
Sbjct: 415 QQVCVNTVGSYECQCHPGYKLHWNKKDC 442
Score = 56.8 bits (131), Expect = 7e-07
Identities = 26/65 (40%), Positives = 32/65 (49%), Gaps = 3/65 (4%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCM 498
C+ C G C C GF L D+ SC+D+DEC D C +C N G+F C C
Sbjct: 334 CDHFCKNIV-GSFDCGCKKGFKLLTDEKSCQDVDEC--SLDRTCDHSCINHPGTFACACN 390
Query: 499 TGYIL 503
GY L
Sbjct: 391 RGYTL 395
Score = 52.4 bits (120), Expect = 1e-05
Identities = 24/60 (40%), Positives = 30/60 (50%), Gaps = 2/60 (3%)
Query: 999 DTQSIQAANKDTGAKRRTL--GCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
++ + + D KRR L C NNGGC C G C+CP+G L DGKTC D
Sbjct: 264 ESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKD 323
Score = 51.2 bits (117), Expect = 3e-05
Identities = 31/97 (31%), Positives = 45/97 (46%), Gaps = 7/97 (7%)
Query: 419 PRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQ 478
P+ D +E C A+ C+ T+Y C+C G+ E + C DIDEC E
Sbjct: 42 PQEDVDECAQGLDDCHADALCQNTP-TSYK----CSCKPGYQ-GEGR-QCEDIDECGNEL 94
Query: 479 DPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
+ C C N G++RC C G++L D +C E
Sbjct: 95 NGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDE 131
Score = 41.1 bits (92), Expect = 0.035
Identities = 19/39 (48%), Positives = 19/39 (48%), Gaps = 1/39 (2%)
Query: 1019 CGKN-NGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
CG NGGC H CL PG C C G L DG C D
Sbjct: 90 CGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLD 128
Score = 41.1 bits (92), Expect = 0.035
Identities = 17/38 (44%), Positives = 18/38 (47%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NGGC H C G C C G KL D K+C D
Sbjct: 327 CQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQD 364
Score = 39.5 bits (88), Expect = 0.11
Identities = 15/40 (37%), Positives = 21/40 (52%)
Query: 1017 LGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
L C NGGC H C G C+C K++ DG++C +
Sbjct: 215 LTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLE 254
Score = 39.1 bits (87), Expect = 0.14
Identities = 16/54 (29%), Positives = 23/54 (42%)
Query: 1298 VIRKNLEGLMDIRAIQSERVLENACGTDNGGCSHLCLRSPLGYTCACPTGMPFE 1351
V N ++D R+L C +NGGC C + G C+CP G +
Sbjct: 262 VTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQ 315
Score = 38.7 bits (86), Expect = 0.19
Identities = 15/36 (41%), Positives = 19/36 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C +NNGGC H C+ G C C G L+ + TC
Sbjct: 132 CLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTC 167
Score = 37.9 bits (84), Expect = 0.33
Identities = 15/36 (41%), Positives = 19/36 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C NNGGC +C+ G C C G KL+ + K C
Sbjct: 407 CSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDC 442
Score = 35.1 bits (77), Expect = 2.3
Identities = 13/37 (35%), Positives = 19/37 (51%)
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPT 518
C +TC +T C C G+ L+ D ++CK E T
Sbjct: 293 CDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQT 329
Score = 35.1 bits (77), Expect = 2.3
Identities = 23/70 (32%), Positives = 27/70 (38%), Gaps = 11/70 (15%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTGMPF---EKS-------TTDQT-PKKCKSHPEEFL 1370
C T NGGC H C + C C G EKS + D+T C +HP F
Sbjct: 327 CQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHSCINHPGTFA 386
Query: 1371 IFATRGSITY 1380
RG Y
Sbjct: 387 CACNRGYTLY 396
Score = 34.7 bits (76), Expect = 3.1
Identities = 15/39 (38%), Positives = 21/39 (53%), Gaps = 1/39 (2%)
Query: 1017 LGCGKNNGGCSHLCLLKP-GGRSCACPIGIKLNKDGKTC 1054
L C + GCSH+C P G +C C G +L K+ + C
Sbjct: 175 LSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC 213
Score = 33.9 bits (74), Expect = 5.3
Identities = 14/27 (51%), Positives = 15/27 (55%), Gaps = 1/27 (3%)
Query: 1322 CGTD-NGGCSHLCLRSPLGYTCACPTG 1347
CG + NGGC H CL P Y C C G
Sbjct: 90 CGNELNGGCVHDCLNIPGNYRCTCFDG 116
Score = 33.5 bits (73), Expect = 7.0
Identities = 11/28 (39%), Positives = 15/28 (53%)
Query: 1320 NACGTDNGGCSHLCLRSPLGYTCACPTG 1347
N C +NGGC +C+ + Y C C G
Sbjct: 405 NECSINNGGCQQVCVNTVGSYECQCHPG 432
>AK131552-1|BAD18686.1| 682|Homo sapiens protein ( Homo sapiens
cDNA FLJ16792 fis, clone TBAES2007379, moderately
similar to Homo sapiens signal peptide, CUB domain,
EGF-like 2 (SCUBE2). ).
Length = 682
Score = 85.4 bits (202), Expect = 2e-15
Identities = 76/270 (28%), Positives = 115/270 (42%), Gaps = 37/270 (13%)
Query: 276 VPKDFQC---DG---DNDCGDWTDEDSCPMVPGSCN------AGEFKCNDGKCIPERWRC 323
+P +++C DG +D + D D C G C G ++C C +
Sbjct: 105 IPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECC---CKEGFFLS 161
Query: 324 DNERDCADGGDE-LNCKPNSIRNCS--LDEYTCADRRCVLKTW--LCDGVRDCT------ 372
DN+ C +E L+C N CS E C + L RDC
Sbjct: 162 DNQHTCIHRSEEGLSCM-NKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHG 220
Query: 373 NGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVC-----DGMKDCPRGDDE-ER 426
NG + +C+ + + + +C PQ + ++ R+C+ R+ GD +R
Sbjct: 221 NGGCQHSCDDTADGPECSCHPQYKMHTDG-RSCLEREDTVLEVTESNTTSVVDGDKRVKR 279
Query: 427 CPLKRKCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQT 485
L C+ C++ C T G C+CP+GF L D +C+DIDEC ++ C
Sbjct: 280 QLLMETCAVNNGGCDRTCKDTSTG-VHCSCPVGFTLQLDGKTCKDIDECQ-TRNGGCDHF 337
Query: 486 CSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C N VGSF CGC G+ L DE+SC+ E
Sbjct: 338 CKNIVGSFDCGCKKGFKLLTDEKSCQDVDE 367
Score = 65.3 bits (152), Expect = 2e-09
Identities = 33/88 (37%), Positives = 45/88 (51%), Gaps = 3/88 (3%)
Query: 423 DEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC 482
DE+ C +CS + C+ CI + G ACAC G+ L + C D +EC C
Sbjct: 358 DEKSCQDVDECSLDRTCDHSCIN-HPGTFACACNRGYTLYGFTH-CGDTNECSINNGG-C 414
Query: 483 SQTCSNTVGSFRCGCMTGYILRPDERSC 510
Q C NTVGS+ C C GY L +++ C
Sbjct: 415 QQVCVNTVGSYECQCHPGYKLHWNKKDC 442
Score = 56.8 bits (131), Expect = 7e-07
Identities = 26/65 (40%), Positives = 32/65 (49%), Gaps = 3/65 (4%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCM 498
C+ C G C C GF L D+ SC+D+DEC D C +C N G+F C C
Sbjct: 334 CDHFCKNIV-GSFDCGCKKGFKLLTDEKSCQDVDEC--SLDRTCDHSCINHPGTFACACN 390
Query: 499 TGYIL 503
GY L
Sbjct: 391 RGYTL 395
Score = 51.2 bits (117), Expect = 3e-05
Identities = 31/97 (31%), Positives = 45/97 (46%), Gaps = 7/97 (7%)
Query: 419 PRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQ 478
P+ D +E C A+ C+ T+Y C+C G+ E + C DIDEC E
Sbjct: 42 PQEDVDECAQGLDDCHADALCQNTP-TSYK----CSCKPGYQ-GEGR-QCEDIDECGNEL 94
Query: 479 DPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
+ C C N G++RC C G++L D +C E
Sbjct: 95 NGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDE 131
Score = 50.8 bits (116), Expect = 4e-05
Identities = 23/60 (38%), Positives = 30/60 (50%), Gaps = 2/60 (3%)
Query: 999 DTQSIQAANKDTGAKRRTL--GCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
++ + + D KR+ L C NNGGC C G C+CP+G L DGKTC D
Sbjct: 264 ESNTTSVVDGDKRVKRQLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKD 323
Score = 41.1 bits (92), Expect = 0.035
Identities = 19/39 (48%), Positives = 19/39 (48%), Gaps = 1/39 (2%)
Query: 1019 CGKN-NGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
CG NGGC H CL PG C C G L DG C D
Sbjct: 90 CGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLD 128
Score = 41.1 bits (92), Expect = 0.035
Identities = 17/38 (44%), Positives = 18/38 (47%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NGGC H C G C C G KL D K+C D
Sbjct: 327 CQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQD 364
Score = 39.5 bits (88), Expect = 0.11
Identities = 15/40 (37%), Positives = 21/40 (52%)
Query: 1017 LGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
L C NGGC H C G C+C K++ DG++C +
Sbjct: 215 LTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLE 254
Score = 38.7 bits (86), Expect = 0.19
Identities = 15/36 (41%), Positives = 19/36 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C +NNGGC H C+ G C C G L+ + TC
Sbjct: 132 CLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTC 167
Score = 37.9 bits (84), Expect = 0.33
Identities = 15/36 (41%), Positives = 19/36 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C NNGGC +C+ G C C G KL+ + K C
Sbjct: 407 CSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDC 442
Score = 37.5 bits (83), Expect = 0.43
Identities = 15/54 (27%), Positives = 23/54 (42%)
Query: 1298 VIRKNLEGLMDIRAIQSERVLENACGTDNGGCSHLCLRSPLGYTCACPTGMPFE 1351
V N ++D ++L C +NGGC C + G C+CP G +
Sbjct: 262 VTESNTTSVVDGDKRVKRQLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQ 315
Score = 35.1 bits (77), Expect = 2.3
Identities = 13/37 (35%), Positives = 19/37 (51%)
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPT 518
C +TC +T C C G+ L+ D ++CK E T
Sbjct: 293 CDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQT 329
Score = 35.1 bits (77), Expect = 2.3
Identities = 23/70 (32%), Positives = 27/70 (38%), Gaps = 11/70 (15%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTGMPF---EKS-------TTDQT-PKKCKSHPEEFL 1370
C T NGGC H C + C C G EKS + D+T C +HP F
Sbjct: 327 CQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHSCINHPGTFA 386
Query: 1371 IFATRGSITY 1380
RG Y
Sbjct: 387 CACNRGYTLY 396
Score = 34.7 bits (76), Expect = 3.1
Identities = 15/39 (38%), Positives = 21/39 (53%), Gaps = 1/39 (2%)
Query: 1017 LGCGKNNGGCSHLCLLKP-GGRSCACPIGIKLNKDGKTC 1054
L C + GCSH+C P G +C C G +L K+ + C
Sbjct: 175 LSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC 213
Score = 33.9 bits (74), Expect = 5.3
Identities = 14/27 (51%), Positives = 15/27 (55%), Gaps = 1/27 (3%)
Query: 1322 CGTD-NGGCSHLCLRSPLGYTCACPTG 1347
CG + NGGC H CL P Y C C G
Sbjct: 90 CGNELNGGCVHDCLNIPGNYRCTCFDG 116
Score = 33.5 bits (73), Expect = 7.0
Identities = 11/28 (39%), Positives = 15/28 (53%)
Query: 1320 NACGTDNGGCSHLCLRSPLGYTCACPTG 1347
N C +NGGC +C+ + Y C C G
Sbjct: 405 NECSINNGGCQQVCVNTVGSYECQCHPG 432
>AK123039-1|BAC85521.1| 971|Homo sapiens protein ( Homo sapiens
cDNA FLJ41044 fis, clone NT2RP7000466, highly similar
to Mus musculus CUB domain and EGF-like repeat
containing 1 (Cegf1). ).
Length = 971
Score = 85.4 bits (202), Expect = 2e-15
Identities = 76/270 (28%), Positives = 115/270 (42%), Gaps = 37/270 (13%)
Query: 276 VPKDFQC---DG---DNDCGDWTDEDSCPMVPGSCN------AGEFKCNDGKCIPERWRC 323
+P +++C DG +D + D D C G C G ++C C +
Sbjct: 105 IPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECC---CKEGFFLS 161
Query: 324 DNERDCADGGDE-LNCKPNSIRNCS--LDEYTCADRRCVLKTW--LCDGVRDCT------ 372
DN+ C +E L+C N CS E C + L RDC
Sbjct: 162 DNQHTCIHRSEEGLSCM-NKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHG 220
Query: 373 NGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVC-----DGMKDCPRGDDE-ER 426
NG + +C+ + + + +C PQ + ++ R+C+ R+ GD +R
Sbjct: 221 NGGCQHSCDDTADGPECSCHPQYKMHTDG-RSCLEREDTVLEVTESNTTSVVDGDKRVKR 279
Query: 427 CPLKRKCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQT 485
L C+ C++ C T G C+CP+GF L D +C+DIDEC ++ C
Sbjct: 280 RLLMETCAVNNGGCDRTCKDTSTG-VHCSCPVGFTLQLDGKTCKDIDECQ-TRNGGCDHF 337
Query: 486 CSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C N VGSF CGC G+ L DE+SC+ E
Sbjct: 338 CKNIVGSFDCGCKKGFKLLTDEKSCQDVDE 367
Score = 65.3 bits (152), Expect = 2e-09
Identities = 33/88 (37%), Positives = 45/88 (51%), Gaps = 3/88 (3%)
Query: 423 DEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC 482
DE+ C +CS + C+ CI + G ACAC G+ L + C D +EC C
Sbjct: 358 DEKSCQDVDECSLDRTCDHSCIN-HPGTFACACNRGYTLYGFTH-CGDTNECSINNGG-C 414
Query: 483 SQTCSNTVGSFRCGCMTGYILRPDERSC 510
Q C NTVGS+ C C GY L +++ C
Sbjct: 415 QQVCVNTVGSYECQCHPGYKLHWNKKDC 442
Score = 56.8 bits (131), Expect = 7e-07
Identities = 26/65 (40%), Positives = 32/65 (49%), Gaps = 3/65 (4%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCM 498
C+ C G C C GF L D+ SC+D+DEC D C +C N G+F C C
Sbjct: 334 CDHFCKNIV-GSFDCGCKKGFKLLTDEKSCQDVDEC--SLDRTCDHSCINHPGTFACACN 390
Query: 499 TGYIL 503
GY L
Sbjct: 391 RGYTL 395
Score = 52.4 bits (120), Expect = 1e-05
Identities = 24/60 (40%), Positives = 30/60 (50%), Gaps = 2/60 (3%)
Query: 999 DTQSIQAANKDTGAKRRTL--GCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
++ + + D KRR L C NNGGC C G C+CP+G L DGKTC D
Sbjct: 264 ESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKD 323
Score = 51.2 bits (117), Expect = 3e-05
Identities = 31/97 (31%), Positives = 45/97 (46%), Gaps = 7/97 (7%)
Query: 419 PRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQ 478
P+ D +E C A+ C+ T+Y C+C G+ E + C DIDEC E
Sbjct: 42 PQEDVDECAQGLDDCHADALCQNTP-TSYK----CSCKPGYQ-GEGR-QCEDIDECGNEL 94
Query: 479 DPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
+ C C N G++RC C G++L D +C E
Sbjct: 95 NGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDE 131
Score = 41.1 bits (92), Expect = 0.035
Identities = 19/39 (48%), Positives = 19/39 (48%), Gaps = 1/39 (2%)
Query: 1019 CGKN-NGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
CG NGGC H CL PG C C G L DG C D
Sbjct: 90 CGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLD 128
Score = 41.1 bits (92), Expect = 0.035
Identities = 17/38 (44%), Positives = 18/38 (47%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NGGC H C G C C G KL D K+C D
Sbjct: 327 CQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQD 364
Score = 39.5 bits (88), Expect = 0.11
Identities = 15/40 (37%), Positives = 21/40 (52%)
Query: 1017 LGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
L C NGGC H C G C+C K++ DG++C +
Sbjct: 215 LTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLE 254
Score = 39.1 bits (87), Expect = 0.14
Identities = 16/54 (29%), Positives = 23/54 (42%)
Query: 1298 VIRKNLEGLMDIRAIQSERVLENACGTDNGGCSHLCLRSPLGYTCACPTGMPFE 1351
V N ++D R+L C +NGGC C + G C+CP G +
Sbjct: 262 VTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQ 315
Score = 38.7 bits (86), Expect = 0.19
Identities = 15/36 (41%), Positives = 19/36 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C +NNGGC H C+ G C C G L+ + TC
Sbjct: 132 CLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTC 167
Score = 38.7 bits (86), Expect = 0.19
Identities = 15/38 (39%), Positives = 20/38 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NNGGC +C+ G C C G KL+ + K C +
Sbjct: 407 CSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVE 444
Score = 35.1 bits (77), Expect = 2.3
Identities = 13/37 (35%), Positives = 19/37 (51%)
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPT 518
C +TC +T C C G+ L+ D ++CK E T
Sbjct: 293 CDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQT 329
Score = 35.1 bits (77), Expect = 2.3
Identities = 23/70 (32%), Positives = 27/70 (38%), Gaps = 11/70 (15%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTGMPF---EKS-------TTDQT-PKKCKSHPEEFL 1370
C T NGGC H C + C C G EKS + D+T C +HP F
Sbjct: 327 CQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHSCINHPGTFA 386
Query: 1371 IFATRGSITY 1380
RG Y
Sbjct: 387 CACNRGYTLY 396
Score = 34.7 bits (76), Expect = 3.1
Identities = 15/39 (38%), Positives = 21/39 (53%), Gaps = 1/39 (2%)
Query: 1017 LGCGKNNGGCSHLCLLKP-GGRSCACPIGIKLNKDGKTC 1054
L C + GCSH+C P G +C C G +L K+ + C
Sbjct: 175 LSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC 213
Score = 33.9 bits (74), Expect = 5.3
Identities = 14/27 (51%), Positives = 15/27 (55%), Gaps = 1/27 (3%)
Query: 1322 CGTD-NGGCSHLCLRSPLGYTCACPTG 1347
CG + NGGC H CL P Y C C G
Sbjct: 90 CGNELNGGCVHDCLNIPGNYRCTCFDG 116
Score = 33.5 bits (73), Expect = 7.0
Identities = 11/28 (39%), Positives = 15/28 (53%)
Query: 1320 NACGTDNGGCSHLCLRSPLGYTCACPTG 1347
N C +NGGC +C+ + Y C C G
Sbjct: 405 NECSINNGGCQQVCVNTVGSYECQCHPG 432
>AJ400877-1|CAB92285.1| 999|Homo sapiens CEGP1 protein protein.
Length = 999
Score = 85.4 bits (202), Expect = 2e-15
Identities = 76/270 (28%), Positives = 115/270 (42%), Gaps = 37/270 (13%)
Query: 276 VPKDFQC---DG---DNDCGDWTDEDSCPMVPGSCN------AGEFKCNDGKCIPERWRC 323
+P +++C DG +D + D D C G C G ++C C +
Sbjct: 105 IPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECC---CKEGFFLS 161
Query: 324 DNERDCADGGDE-LNCKPNSIRNCS--LDEYTCADRRCVLKTW--LCDGVRDCT------ 372
DN+ C +E L+C N CS E C + L RDC
Sbjct: 162 DNQHTCIHRSEEGLSCM-NKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHG 220
Query: 373 NGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVC-----DGMKDCPRGDDE-ER 426
NG + +C+ + + + +C PQ + ++ R+C+ R+ GD +R
Sbjct: 221 NGGCQHSCDDTADGPECSCHPQYKMHTDG-RSCLEREDTVLEVTESNTTSVVDGDKRVKR 279
Query: 427 CPLKRKCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQT 485
L C+ C++ C T G C+CP+GF L D +C+DIDEC ++ C
Sbjct: 280 RLLMETCAVNNGGCDRTCKDTSTG-VHCSCPVGFTLQLDGKTCKDIDECQ-TRNGGCDHF 337
Query: 486 CSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C N VGSF CGC G+ L DE+SC+ E
Sbjct: 338 CKNIVGSFDCGCKKGFKLLTDEKSCQDVDE 367
Score = 65.3 bits (152), Expect = 2e-09
Identities = 33/88 (37%), Positives = 45/88 (51%), Gaps = 3/88 (3%)
Query: 423 DEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC 482
DE+ C +CS + C+ CI + G ACAC G+ L + C D +EC C
Sbjct: 358 DEKSCQDVDECSLDRTCDHSCIN-HPGTFACACNRGYTLYGFTH-CGDTNECSINNGG-C 414
Query: 483 SQTCSNTVGSFRCGCMTGYILRPDERSC 510
Q C NTVGS+ C C GY L +++ C
Sbjct: 415 QQVCVNTVGSYECQCHPGYKLHWNKKDC 442
Score = 56.8 bits (131), Expect = 7e-07
Identities = 26/65 (40%), Positives = 32/65 (49%), Gaps = 3/65 (4%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCM 498
C+ C G C C GF L D+ SC+D+DEC D C +C N G+F C C
Sbjct: 334 CDHFCKNIV-GSFDCGCKKGFKLLTDEKSCQDVDEC--SLDRTCDHSCINHPGTFACACN 390
Query: 499 TGYIL 503
GY L
Sbjct: 391 RGYTL 395
Score = 52.4 bits (120), Expect = 1e-05
Identities = 24/60 (40%), Positives = 30/60 (50%), Gaps = 2/60 (3%)
Query: 999 DTQSIQAANKDTGAKRRTL--GCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
++ + + D KRR L C NNGGC C G C+CP+G L DGKTC D
Sbjct: 264 ESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKD 323
Score = 51.2 bits (117), Expect = 3e-05
Identities = 31/97 (31%), Positives = 45/97 (46%), Gaps = 7/97 (7%)
Query: 419 PRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQ 478
P+ D +E C A+ C+ T+Y C+C G+ E + C DIDEC E
Sbjct: 42 PQEDVDECAQGLDDCHADALCQNTP-TSYK----CSCKPGYQ-GEGR-QCEDIDECGNEL 94
Query: 479 DPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
+ C C N G++RC C G++L D +C E
Sbjct: 95 NGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDE 131
Score = 41.1 bits (92), Expect = 0.035
Identities = 19/39 (48%), Positives = 19/39 (48%), Gaps = 1/39 (2%)
Query: 1019 CGKN-NGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
CG NGGC H CL PG C C G L DG C D
Sbjct: 90 CGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLD 128
Score = 41.1 bits (92), Expect = 0.035
Identities = 17/38 (44%), Positives = 18/38 (47%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NGGC H C G C C G KL D K+C D
Sbjct: 327 CQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQD 364
Score = 39.5 bits (88), Expect = 0.11
Identities = 15/40 (37%), Positives = 21/40 (52%)
Query: 1017 LGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
L C NGGC H C G C+C K++ DG++C +
Sbjct: 215 LTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLE 254
Score = 39.1 bits (87), Expect = 0.14
Identities = 16/54 (29%), Positives = 23/54 (42%)
Query: 1298 VIRKNLEGLMDIRAIQSERVLENACGTDNGGCSHLCLRSPLGYTCACPTGMPFE 1351
V N ++D R+L C +NGGC C + G C+CP G +
Sbjct: 262 VTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQ 315
Score = 38.7 bits (86), Expect = 0.19
Identities = 15/36 (41%), Positives = 19/36 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C +NNGGC H C+ G C C G L+ + TC
Sbjct: 132 CLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTC 167
Score = 38.7 bits (86), Expect = 0.19
Identities = 15/38 (39%), Positives = 20/38 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NNGGC +C+ G C C G KL+ + K C +
Sbjct: 407 CSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVE 444
Score = 35.1 bits (77), Expect = 2.3
Identities = 13/37 (35%), Positives = 19/37 (51%)
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPT 518
C +TC +T C C G+ L+ D ++CK E T
Sbjct: 293 CDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQT 329
Score = 35.1 bits (77), Expect = 2.3
Identities = 23/70 (32%), Positives = 27/70 (38%), Gaps = 11/70 (15%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTGMPF---EKS-------TTDQT-PKKCKSHPEEFL 1370
C T NGGC H C + C C G EKS + D+T C +HP F
Sbjct: 327 CQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHSCINHPGTFA 386
Query: 1371 IFATRGSITY 1380
RG Y
Sbjct: 387 CACNRGYTLY 396
Score = 34.7 bits (76), Expect = 3.1
Identities = 15/39 (38%), Positives = 21/39 (53%), Gaps = 1/39 (2%)
Query: 1017 LGCGKNNGGCSHLCLLKP-GGRSCACPIGIKLNKDGKTC 1054
L C + GCSH+C P G +C C G +L K+ + C
Sbjct: 175 LSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC 213
Score = 33.9 bits (74), Expect = 5.3
Identities = 14/27 (51%), Positives = 15/27 (55%), Gaps = 1/27 (3%)
Query: 1322 CGTD-NGGCSHLCLRSPLGYTCACPTG 1347
CG + NGGC H CL P Y C C G
Sbjct: 90 CGNELNGGCVHDCLNIPGNYRCTCFDG 116
Score = 33.5 bits (73), Expect = 7.0
Identities = 11/28 (39%), Positives = 15/28 (53%)
Query: 1320 NACGTDNGGCSHLCLRSPLGYTCACPTG 1347
N C +NGGC +C+ + Y C C G
Sbjct: 405 NECSINNGGCQQVCVNTVGSYECQCHPG 432
>BC032109-1|AAH32109.1| 859|Homo sapiens low density
lipoprotein-related protein 12 protein.
Length = 859
Score = 83.8 bits (198), Expect = 5e-15
Identities = 51/147 (34%), Positives = 68/147 (46%), Gaps = 15/147 (10%)
Query: 238 FCAKKALDNAANPRSTWNQPVELMRCAEIDFECK-NTKCVPKDFQCDGDNDCGDWTDEDS 296
FCA K NAA + Q C + C N C + +CDG C + DE +
Sbjct: 354 FCADKV--NAARGFNATYQVDGF--CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETN 409
Query: 297 CPMVPGSCNAGEFKCN-DGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCAD 355
C M C EF C+ +G C P RC+ + C +G DE NC C + C +
Sbjct: 410 CTM----CQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCF-----FCQPGNFHCKN 460
Query: 356 RRCVLKTWLCDGVRDCTNGEDEMNCEV 382
RCV ++W+CD DC +G DE NC V
Sbjct: 461 NRCVFESWVCDSQDDCGDGSDEENCPV 487
Score = 71.3 bits (167), Expect = 3e-11
Identities = 44/132 (33%), Positives = 55/132 (41%), Gaps = 17/132 (12%)
Query: 300 VPGSCNAGEFKCNDG-KCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRR- 357
V G C E C C E+ RCD C +G DE NC C +E+ C+
Sbjct: 371 VDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTM-----CQKEEFPCSRNGV 425
Query: 358 CVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKD 417
C ++ C+ C NG DE NC + C+P N CV VCD D
Sbjct: 426 CYPRSDRCNYQNHCPNGSDEKNC--------FFCQPGNFHCKN--NRCVFESWVCDSQDD 475
Query: 418 CPRGDDEERCPL 429
C G DEE CP+
Sbjct: 476 CGDGSDEENCPV 487
Score = 67.3 bits (157), Expect = 5e-10
Identities = 30/92 (32%), Positives = 50/92 (54%), Gaps = 12/92 (13%)
Query: 303 SCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPN-------SIRNCSLDEYTCAD 355
+C +F+C +GKCIPE W+C+N +C D DE C + + C+ +++ C
Sbjct: 165 NCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLS 224
Query: 356 R-----RCVLKTWLCDGVRDCTNGEDEMNCEV 382
R C+ ++ CDG DC + DE++C+V
Sbjct: 225 RFTKVYTCLPESLKCDGNIDCLDLGDEIDCDV 256
Score = 62.5 bits (145), Expect = 1e-08
Identities = 31/89 (34%), Positives = 47/89 (52%), Gaps = 13/89 (14%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSC-----PMVPGS---CNAGEFKCNDG 314
CA F C N KC+P+ ++C+ ++CGD +DE+ C P + C +F+C
Sbjct: 166 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 225
Query: 315 -----KCIPERWRCDNERDCADGGDELNC 338
C+PE +CD DC D GDE++C
Sbjct: 226 FTKVYTCLPESLKCDGNIDCLDLGDEIDC 254
Score = 51.2 bits (117), Expect = 3e-05
Identities = 17/38 (44%), Positives = 27/38 (71%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMV 300
C +F CKN +CV + + CD +DCGD +DE++CP++
Sbjct: 451 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVI 488
Score = 48.8 bits (111), Expect = 2e-04
Identities = 33/116 (28%), Positives = 49/116 (42%), Gaps = 9/116 (7%)
Query: 111 DDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTICHST 170
D+ C T C K F C + C P R ++C +
Sbjct: 406 DETNC-TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDE----KNCFFCQPGNFHCKN 460
Query: 171 NVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIAL 226
N C+ W+CD +DCGD SDE NC V+ + ++ +A IG +I ++IAL
Sbjct: 461 NRCVFESWVCDSQDDCGDGSDEENCPVIVPTRVITAA----VIGSLICGLLLVIAL 512
Score = 33.9 bits (74), Expect = 5.3
Identities = 13/25 (52%), Positives = 16/25 (64%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDV 197
C+ CDG+ DC D DEI+CDV
Sbjct: 232 CLPESLKCDGNIDCLDLGDEIDCDV 256
>AF166350-1|AAD44360.1| 859|Homo sapiens ST7 protein protein.
Length = 859
Score = 83.8 bits (198), Expect = 5e-15
Identities = 51/147 (34%), Positives = 68/147 (46%), Gaps = 15/147 (10%)
Query: 238 FCAKKALDNAANPRSTWNQPVELMRCAEIDFECK-NTKCVPKDFQCDGDNDCGDWTDEDS 296
FCA K NAA + Q C + C N C + +CDG C + DE +
Sbjct: 354 FCADKV--NAARGFNATYQVDGF--CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETN 409
Query: 297 CPMVPGSCNAGEFKCN-DGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCAD 355
C M C EF C+ +G C P RC+ + C +G DE NC C + C +
Sbjct: 410 CTM----CQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCF-----FCQPGNFHCKN 460
Query: 356 RRCVLKTWLCDGVRDCTNGEDEMNCEV 382
RCV ++W+CD DC +G DE NC V
Sbjct: 461 NRCVFESWVCDSQDDCGDGSDEENCPV 487
Score = 71.3 bits (167), Expect = 3e-11
Identities = 44/132 (33%), Positives = 55/132 (41%), Gaps = 17/132 (12%)
Query: 300 VPGSCNAGEFKCNDG-KCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRR- 357
V G C E C C E+ RCD C +G DE NC C +E+ C+
Sbjct: 371 VDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTM-----CQKEEFPCSRNGV 425
Query: 358 CVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKD 417
C ++ C+ C NG DE NC + C+P N CV VCD D
Sbjct: 426 CYPRSDRCNYQNHCPNGSDEKNC--------FFCQPGNFHCKN--NRCVFESWVCDSQDD 475
Query: 418 CPRGDDEERCPL 429
C G DEE CP+
Sbjct: 476 CGDGSDEENCPV 487
Score = 67.3 bits (157), Expect = 5e-10
Identities = 30/92 (32%), Positives = 50/92 (54%), Gaps = 12/92 (13%)
Query: 303 SCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPN-------SIRNCSLDEYTCAD 355
+C +F+C +GKCIPE W+C+N +C D DE C + + C+ +++ C
Sbjct: 165 NCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLS 224
Query: 356 R-----RCVLKTWLCDGVRDCTNGEDEMNCEV 382
R C+ ++ CDG DC + DE++C+V
Sbjct: 225 RFTKVYTCLPESLKCDGNIDCLDLGDEIDCDV 256
Score = 62.5 bits (145), Expect = 1e-08
Identities = 31/89 (34%), Positives = 47/89 (52%), Gaps = 13/89 (14%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSC-----PMVPGS---CNAGEFKCNDG 314
CA F C N KC+P+ ++C+ ++CGD +DE+ C P + C +F+C
Sbjct: 166 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 225
Query: 315 -----KCIPERWRCDNERDCADGGDELNC 338
C+PE +CD DC D GDE++C
Sbjct: 226 FTKVYTCLPESLKCDGNIDCLDLGDEIDC 254
Score = 51.2 bits (117), Expect = 3e-05
Identities = 17/38 (44%), Positives = 27/38 (71%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMV 300
C +F CKN +CV + + CD +DCGD +DE++CP++
Sbjct: 451 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVI 488
Score = 48.8 bits (111), Expect = 2e-04
Identities = 33/116 (28%), Positives = 49/116 (42%), Gaps = 9/116 (7%)
Query: 111 DDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTICHST 170
D+ C T C K F C + C P R ++C +
Sbjct: 406 DETNC-TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDE----KNCFFCQPGNFHCKN 460
Query: 171 NVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIAL 226
N C+ W+CD +DCGD SDE NC V+ + ++ +A IG +I ++IAL
Sbjct: 461 NRCVFESWVCDSQDDCGDGSDEENCPVIVPTRVITAA----VIGSLICGLLLVIAL 512
Score = 33.9 bits (74), Expect = 5.3
Identities = 13/25 (52%), Positives = 16/25 (64%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDV 197
C+ CDG+ DC D DEI+CDV
Sbjct: 232 CLPESLKCDGNIDCLDLGDEIDCDV 256
>AB208957-1|BAD92194.1| 793|Homo sapiens suppression of
tumorigenicity variant protein.
Length = 793
Score = 83.8 bits (198), Expect = 5e-15
Identities = 51/147 (34%), Positives = 68/147 (46%), Gaps = 15/147 (10%)
Query: 238 FCAKKALDNAANPRSTWNQPVELMRCAEIDFECK-NTKCVPKDFQCDGDNDCGDWTDEDS 296
FCA K NAA + Q C + C N C + +CDG C + DE +
Sbjct: 288 FCADKV--NAARGFNATYQVDGF--CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETN 343
Query: 297 CPMVPGSCNAGEFKCN-DGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCAD 355
C M C EF C+ +G C P RC+ + C +G DE NC C + C +
Sbjct: 344 CTM----CQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCF-----FCQPGNFHCKN 394
Query: 356 RRCVLKTWLCDGVRDCTNGEDEMNCEV 382
RCV ++W+CD DC +G DE NC V
Sbjct: 395 NRCVFESWVCDSQDDCGDGSDEENCPV 421
Score = 71.3 bits (167), Expect = 3e-11
Identities = 44/132 (33%), Positives = 55/132 (41%), Gaps = 17/132 (12%)
Query: 300 VPGSCNAGEFKCNDG-KCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRR- 357
V G C E C C E+ RCD C +G DE NC C +E+ C+
Sbjct: 305 VDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTM-----CQKEEFPCSRNGV 359
Query: 358 CVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKD 417
C ++ C+ C NG DE NC + C+P N CV VCD D
Sbjct: 360 CYPRSDRCNYQNHCPNGSDEKNC--------FFCQPGNFHCKN--NRCVFESWVCDSQDD 409
Query: 418 CPRGDDEERCPL 429
C G DEE CP+
Sbjct: 410 CGDGSDEENCPV 421
Score = 67.3 bits (157), Expect = 5e-10
Identities = 30/92 (32%), Positives = 50/92 (54%), Gaps = 12/92 (13%)
Query: 303 SCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPN-------SIRNCSLDEYTCAD 355
+C +F+C +GKCIPE W+C+N +C D DE C + + C+ +++ C
Sbjct: 99 NCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLS 158
Query: 356 R-----RCVLKTWLCDGVRDCTNGEDEMNCEV 382
R C+ ++ CDG DC + DE++C+V
Sbjct: 159 RFTKVYTCLPESLKCDGNIDCLDLGDEIDCDV 190
Score = 62.5 bits (145), Expect = 1e-08
Identities = 31/89 (34%), Positives = 47/89 (52%), Gaps = 13/89 (14%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSC-----PMVPGS---CNAGEFKCNDG 314
CA F C N KC+P+ ++C+ ++CGD +DE+ C P + C +F+C
Sbjct: 100 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 159
Query: 315 -----KCIPERWRCDNERDCADGGDELNC 338
C+PE +CD DC D GDE++C
Sbjct: 160 FTKVYTCLPESLKCDGNIDCLDLGDEIDC 188
Score = 51.2 bits (117), Expect = 3e-05
Identities = 17/38 (44%), Positives = 27/38 (71%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMV 300
C +F CKN +CV + + CD +DCGD +DE++CP++
Sbjct: 385 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVI 422
Score = 48.8 bits (111), Expect = 2e-04
Identities = 33/116 (28%), Positives = 49/116 (42%), Gaps = 9/116 (7%)
Query: 111 DDAGCITPCLKINFSCQISCTCIPMEKRXXXXXXXXXXXXXXXXXRSCDEHENRTICHST 170
D+ C T C K F C + C P R ++C +
Sbjct: 340 DETNC-TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDE----KNCFFCQPGNFHCKN 394
Query: 171 NVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTVLIAL 226
N C+ W+CD +DCGD SDE NC V+ + ++ +A IG +I ++IAL
Sbjct: 395 NRCVFESWVCDSQDDCGDGSDEENCPVIVPTRVITAA----VIGSLICGLLLVIAL 446
Score = 33.9 bits (74), Expect = 5.3
Identities = 13/25 (52%), Positives = 16/25 (64%)
Query: 173 CIALEWLCDGDNDCGDFSDEINCDV 197
C+ CDG+ DC D DEI+CDV
Sbjct: 166 CLPESLKCDGNIDCLDLGDEIDCDV 190
>AY358895-1|AAQ89254.1| 915|Homo sapiens MATN2 protein.
Length = 915
Score = 82.2 bits (194), Expect = 2e-14
Identities = 74/261 (28%), Positives = 105/261 (40%), Gaps = 33/261 (12%)
Query: 273 TKCVPKDFQCDGDNDCGDWTDEDSCPMVPGS----CNAGEFKCNDGK-------CIPERW 321
T C +D D++C E C VPGS C +G DGK C E
Sbjct: 275 TTCRIQDLCAMEDHNC-----EQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENH 329
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNC 380
C++E ADG C N DE TC C L C+ +C N E+ C
Sbjct: 330 GCEHECVNADGSYLCQCHEGFALNP--DEKTCTRINYCALNKPGCE--HECVNMEESYYC 385
Query: 381 EV----SCEEDQYTCRPQEHLMSNAF---RNCVNRKH--VCDGMKDCPRGDDEERCPLKR 431
+ + + TC +H + C+N + VC + +D + C
Sbjct: 386 RCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVD 445
Query: 432 KCS-AEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTV 490
C ++ CE C+ D AC CP G +L D +C +D C D C +C ++
Sbjct: 446 YCLLSDHGCEYSCVNM-DRSFACQCPEGHVLRSDGKTCAKLDSCALG-DHGCEHSCVSSE 503
Query: 491 GSFRCGCMTGYILRPDERSCK 511
SF C C GYILR D ++C+
Sbjct: 504 DSFVCQCFEGYILREDGKTCR 524
Score = 74.9 bits (176), Expect = 2e-12
Identities = 41/125 (32%), Positives = 58/125 (46%), Gaps = 8/125 (6%)
Query: 389 YTCRPQEHLMSNAFRNCVN--RKHVCDGMKDCPRGDDEERCPLKRKCSAEE-KCEKLCIT 445
+ C EH N C+N +VC + D+ C ++ C+ E+ CE+LC+
Sbjct: 240 HMCSTLEH---NCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVN 296
Query: 446 TYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRP 505
G C C G+ LAED C +D C E C C N GS+ C C G+ L P
Sbjct: 297 V-PGSFVCQCYSGYALAEDGKRCVAVDYCASENHG-CEHECVNADGSYLCQCHEGFALNP 354
Query: 506 DERSC 510
DE++C
Sbjct: 355 DEKTC 359
Score = 68.9 bits (161), Expect = 2e-10
Identities = 48/199 (24%), Positives = 86/199 (43%), Gaps = 18/199 (9%)
Query: 317 IPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLK--TWLCDGVRDCTNG 374
IP + C ++ D+ C+ + C+++++ C ++ CV +++C
Sbjct: 256 IPGSYVCRCKQGYILNSDQTTCRIQDL--CAMEDHNC-EQLCVNVPGSFVCQCYSGYALA 312
Query: 375 EDEMNCEVS--CEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRK 432
ED C C + + C EH NA + ++C + DE+ C
Sbjct: 313 EDGKRCVAVDYCASENHGC---EHECVNA-----DGSYLCQCHEGFALNPDEKTCTRINY 364
Query: 433 CSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVG 491
C+ + CE C+ + + C C G+ L + +C +D C +QD C Q C NT
Sbjct: 365 CALNKPGCEHECVNMEESYY-CRCHRGYTLDPNGKTCSRVDHCA-QQDHGCEQLCLNTED 422
Query: 492 SFRCGCMTGYILRPDERSC 510
SF C C G+++ D ++C
Sbjct: 423 SFVCQCSEGFLINEDLKTC 441
Score = 68.1 bits (159), Expect = 3e-10
Identities = 68/237 (28%), Positives = 95/237 (40%), Gaps = 39/237 (16%)
Query: 310 KCNDGKCI-PERWRCDNERDCA--DGGDE---LNCKPNSIRNCSLDEYTCADRRCVLKTW 363
+C+ G + P C CA D G E LN + + + CS D LKT
Sbjct: 386 RCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINED----LKT- 440
Query: 364 LCDGVRDCTNGEDEMNCEVSCE--EDQYTCR-PQEHLMSNAFRNCVNR----------KH 410
C V C + CE SC + + C+ P+ H++ + + C +H
Sbjct: 441 -CSRVDYCLLSDH--GCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEH 497
Query: 411 VCDGMKD-----CPRG----DDEERCPLKRKCSA-EEKCEKLCITTYDGHAACACPMGFL 460
C +D C G +D + C K C A + CE +C+ + D + C C GF
Sbjct: 498 SCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYT-CECLEGFR 556
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESP 517
LAED CR D C C C N S+ C C G++L D R CK E P
Sbjct: 557 LAEDGKRCRRKDVCKSTHHG-CEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGP 612
Score = 40.7 bits (91), Expect = 0.046
Identities = 19/43 (44%), Positives = 20/43 (46%), Gaps = 2/43 (4%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINY 1061
C N GC H C+ G C C G LN D KTC INY
Sbjct: 324 CASENHGCEHECVNADGSYLCQCHEGFALNPDEKTCT--RINY 364
Score = 38.7 bits (86), Expect = 0.19
Identities = 20/54 (37%), Positives = 27/54 (50%), Gaps = 4/54 (7%)
Query: 1014 RRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDG---KTCADGPINYLIF 1064
RR C + GC H+C+ C C G L +DG K C +GPI+ L+F
Sbjct: 565 RRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPID-LVF 617
Score = 37.9 bits (84), Expect = 0.33
Identities = 18/49 (36%), Positives = 24/49 (48%)
Query: 1007 NKDTGAKRRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCA 1055
N+D R C ++ GC + C+ +C CP G L DGKTCA
Sbjct: 435 NEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCA 483
Score = 37.1 bits (82), Expect = 0.57
Identities = 18/51 (35%), Positives = 22/51 (43%)
Query: 1005 AANKDTGAKRRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCA 1055
A N D R C N GC H C+ C C G L+ +GKTC+
Sbjct: 351 ALNPDEKTCTRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCS 401
Score = 37.1 bits (82), Expect = 0.57
Identities = 11/25 (44%), Positives = 17/25 (68%)
Query: 1631 CKESNGGCSHLCLFRGHEYICACPD 1655
CK ++ GC H+C+ G+ YIC C +
Sbjct: 570 CKSTHHGCEHICVNNGNSYICKCSE 594
Score = 36.7 bits (81), Expect = 0.76
Identities = 13/30 (43%), Positives = 18/30 (60%)
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCK 511
C+ C N GS+ C C GYIL D+ +C+
Sbjct: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCR 278
Score = 36.7 bits (81), Expect = 0.76
Identities = 18/59 (30%), Positives = 30/59 (50%), Gaps = 3/59 (5%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINY-LIFAHRVDIRVISLD 1076
C + + GC LCL C C G +N+D KTC+ ++Y L+ H + +++D
Sbjct: 406 CAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCS--RVDYCLLSDHGCEYSCVNMD 462
Score = 36.7 bits (81), Expect = 0.76
Identities = 18/59 (30%), Positives = 29/59 (49%), Gaps = 3/59 (5%)
Query: 1319 ENACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGS 1377
++ C + + GC H+C+ + Y C C G F + + KKC P + L+F GS
Sbjct: 567 KDVCKSTHHGCEHICVNNGNSYICKCSEG--FVLAEDGRRCKKCTEGPID-LVFVIDGS 622
Score = 36.3 bits (80), Expect = 1.00
Identities = 15/41 (36%), Positives = 21/41 (51%)
Query: 1014 RRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
RR C + GC H+C+ +C C G +L +DGK C
Sbjct: 524 RRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRC 564
Score = 35.1 bits (77), Expect = 2.3
Identities = 14/36 (38%), Positives = 16/36 (44%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C C+H C+ PG C C G LN D TC
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTC 277
Score = 35.1 bits (77), Expect = 2.3
Identities = 14/36 (38%), Positives = 17/36 (47%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C + C LC+ PG C C G L +DGK C
Sbjct: 283 CAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRC 318
Score = 34.7 bits (76), Expect = 3.1
Identities = 14/36 (38%), Positives = 17/36 (47%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C + GC H C+ C C G L +DGKTC
Sbjct: 488 CALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTC 523
Score = 33.1 bits (72), Expect = 9.3
Identities = 14/37 (37%), Positives = 19/37 (51%), Gaps = 3/37 (8%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTGM---PFEKSTT 1355
C ++N GC H C+ + Y C C G P EK+ T
Sbjct: 324 CASENHGCEHECVNADGSYLCQCHEGFALNPDEKTCT 360
>AY358898-1|AAQ89257.1| 448|Homo sapiens FBLN5 protein.
Length = 448
Score = 81.4 bits (192), Expect = 3e-14
Identities = 50/171 (29%), Positives = 70/171 (40%), Gaps = 12/171 (7%)
Query: 353 CAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ-----EHLMSNAFRNCV 406
C D C + C+ + C N E C SC + + Q E + C
Sbjct: 125 CVDVDECATDSHQCNPTQICINTEGGYTC--SCTDGYWLLEGQCLDIDECRYGYCQQLCA 182
Query: 407 N--RKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAED 464
N + C +D C +C+ E C + C+ TY G C C G+ L ED
Sbjct: 183 NVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTY-GSLICRCDPGYELEED 241
Query: 465 KYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C D+DEC + + +C C N G++ C C GYIL D RSC+ E
Sbjct: 242 GVHCSDMDECSFSEF-LCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINE 291
Score = 67.3 bits (157), Expect = 5e-10
Identities = 36/100 (36%), Positives = 52/100 (52%), Gaps = 9/100 (9%)
Query: 422 DDEERCPLKRKCSAEE-KCE--KLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQ 478
D+ +C +C+ + +C ++CI T G+ C+C G+ L E + C DIDEC Y
Sbjct: 120 DESNQCVDVDECATDSHQCNPTQICINTEGGYT-CSCTDGYWLLEGQ--CLDIDECRYGY 176
Query: 479 DPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPT 518
C Q C+N GS+ C C G+ L D RSC+ E T
Sbjct: 177 ---CQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECAT 213
Score = 64.5 bits (150), Expect = 3e-09
Identities = 64/235 (27%), Positives = 96/235 (40%), Gaps = 36/235 (15%)
Query: 311 CNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDG--- 367
C G + E +C + +CA D C P I + YTC+ C WL +G
Sbjct: 113 CRFGYQMDESNQCVDVDECAT--DSHQCNPTQICINTEGGYTCS---CTDGYWLLEGQCL 167
Query: 368 -VRDCTNGEDEMNC-----EVSC--------EEDQYTCRPQEHLMSN--AFRNCVNR--K 409
+ +C G + C SC ED +C+ + + CVN
Sbjct: 168 DIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGS 227
Query: 410 HVCDGMKDCPRGDDEERCPLKRKCSAEE-KCEKLCITTYDGHAACACPMGFLLAEDKYSC 468
+C +D C +CS E C+ C+ G C+CP G++L +D SC
Sbjct: 228 LICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQ-PGTYFCSCPPGYILLDDNRSC 286
Query: 469 RDIDECMYEQDPVCS--QTCSNTVGSFRC----GCMTGYILRPDERSCKPTGESP 517
+DI+EC + ++ C+ QTC N G F+C C Y LR + C E+P
Sbjct: 287 QDINECEH-RNHTCNLQQTCYNLQGGFKCIDPIRCEEPY-LRISDNRCMCPAENP 339
Score = 41.1 bits (92), Expect = 0.035
Identities = 16/33 (48%), Positives = 19/33 (57%)
Query: 1024 GGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
G C LC PG SC C G LN+DG++C D
Sbjct: 175 GYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQD 207
Score = 35.1 bits (77), Expect = 2.3
Identities = 13/31 (41%), Positives = 18/31 (58%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C H C+ +PG C+CP G L D ++C D
Sbjct: 258 CQHECVNQPGTYFCSCPPGYILLDDNRSCQD 288
>AF525689-1|AAN77133.1| 988|Homo sapiens signal
peptide-CUB-EGF-like domain containing protein 1
protein.
Length = 988
Score = 81.4 bits (192), Expect = 3e-14
Identities = 78/277 (28%), Positives = 117/277 (42%), Gaps = 44/277 (15%)
Query: 262 RCAEIDFECKNT--------KCV--PKDFQC---DG---DNDCGDWTDEDSCPMVPGSC- 304
+C +ID EC+N +C+ P +++C DG +D + D D C G C
Sbjct: 71 QCGDID-ECENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQ 129
Query: 305 ----NA-GEFKCNDGKCIPERWRCDNERDCADGGDE-LNCKPNSIRNCSLDEYTCADRRC 358
NA G ++C +C + DN+ C +E +NC N C+ + C R
Sbjct: 130 QICVNAMGSYEC---QCHSGFFLSDNQHTCIHRSNEGMNCM-NKDHGCA---HIC--RET 180
Query: 359 VLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDC 418
CD +++ +C ++C C +H + H K
Sbjct: 181 PKGGVACDCRPGFDLAQNQKDCTLTCNYGNGGC---QHSCEDTDTGPTCGCH----QKYA 233
Query: 419 PRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQ 478
P D R ++ C++ C T G C+CP+GF L D +C+DI+EC+
Sbjct: 234 PHSDG--RTCIETCAVNNGGCDRTCKDTATG-VRCSCPVGFTLQPDGKTCKDINECLVNN 290
Query: 479 DPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C C NTVGSF CGC GY L DER+C+ E
Sbjct: 291 GG-CDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDE 326
Score = 70.1 bits (164), Expect = 7e-11
Identities = 56/200 (28%), Positives = 81/200 (40%), Gaps = 13/200 (6%)
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV 382
C + + D G C + D TC + C + CD T +C V
Sbjct: 213 CQHSCEDTDTGPTCGCHQKYAPHS--DGRTCIET-CAVNNGGCDRTCKDTATGVRCSCPV 269
Query: 383 --SCEEDQYTCRP-QEHLMSNAFRNCVNRKHVCDGMKDCPRG----DDEERCPLKRKCSA 435
+ + D TC+ E L++N + R V C +G DE C +CS
Sbjct: 270 GFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSF 329
Query: 436 EEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRC 495
E C+ +CI + G C C G++L + C D+DEC C Q C NT GS+ C
Sbjct: 330 ERTCDHICINS-PGSFQCLCHRGYILYGTTH-CGDVDECSMSNGS-CDQGCVNTKGSYEC 386
Query: 496 GCMTGYILRPDERSCKPTGE 515
C G L + + C TG+
Sbjct: 387 VCPPGRRLHWNRKDCVETGK 406
Score = 49.6 bits (113), Expect = 1e-04
Identities = 19/38 (50%), Positives = 21/38 (55%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NNGGC C G C+CP+G L DGKTC D
Sbjct: 245 CAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKD 282
Score = 44.0 bits (99), Expect = 0.005
Identities = 23/64 (35%), Positives = 31/64 (48%), Gaps = 3/64 (4%)
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQ-DPVCSQTCSNTVGSFRCGCMTGYILRPDERSCK 511
C C G+ E K C DIDEC + + C C N G++RC C G++L D +C
Sbjct: 59 CLCKPGYK-GEGK-QCGDIDECENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCL 116
Query: 512 PTGE 515
E
Sbjct: 117 DVDE 120
Score = 42.7 bits (96), Expect = 0.012
Identities = 18/38 (47%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NNGGC H C G C C G KL D +TC D
Sbjct: 286 CLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQD 323
Score = 41.1 bits (92), Expect = 0.035
Identities = 51/213 (23%), Positives = 78/213 (36%), Gaps = 30/213 (14%)
Query: 316 CIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNG 374
C CD R C D + C D TC D C++ CD T G
Sbjct: 245 CAVNNGGCD--RTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVG 302
Query: 375 EDEMNCEVSCE--EDQYTC---------RPQEHLMSNA---FRNCVNRKHVCDGMKDCPR 420
E C + D+ TC R +H+ N+ F+ +R ++ G C
Sbjct: 303 SFECGCRKGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLCHRGYILYGTTHC-- 360
Query: 421 GDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECM--YEQ 478
GD +E C + + C++ C+ T G C CP G L ++ C + +C+ +
Sbjct: 361 GDVDE-CSM-----SNGSCDQGCVNT-KGSYECVCPPGRRLHWNRKDCVETGKCLSRAKT 413
Query: 479 DPVCSQTCSNTVGSFRC--GCMTGYILRPDERS 509
P +CS G C C + PD +
Sbjct: 414 SPRAQLSCSKAGGVESCFLSCPAHTLFVPDSEN 446
Score = 39.1 bits (87), Expect = 0.14
Identities = 16/34 (47%), Positives = 17/34 (50%)
Query: 1023 NGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
NGGC H C+ PG C C G L DG C D
Sbjct: 84 NGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLD 117
Score = 38.7 bits (86), Expect = 0.19
Identities = 16/41 (39%), Positives = 20/41 (48%)
Query: 1016 TLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
TL C NGGC H C G +C C + DG+TC +
Sbjct: 203 TLTCNYGNGGCQHSCEDTDTGPTCGCHQKYAPHSDGRTCIE 243
Score = 36.7 bits (81), Expect = 0.76
Identities = 14/36 (38%), Positives = 18/36 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C NNGGC +C+ G C C G L+ + TC
Sbjct: 121 CQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTC 156
Score = 35.5 bits (78), Expect = 1.7
Identities = 12/36 (33%), Positives = 16/36 (44%)
Query: 1316 RVLENACGTDNGGCSHLCLRSPLGYTCACPTGMPFE 1351
R C +NGGC C + G C+CP G +
Sbjct: 239 RTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQ 274
Score = 35.5 bits (78), Expect = 1.7
Identities = 13/38 (34%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C +NG C C+ G C CP G +L+ + K C +
Sbjct: 366 CSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNRKDCVE 403
Score = 33.5 bits (73), Expect = 7.0
Identities = 14/39 (35%), Positives = 21/39 (53%), Gaps = 1/39 (2%)
Query: 1017 LGCGKNNGGCSHLCLLKP-GGRSCACPIGIKLNKDGKTC 1054
+ C + GC+H+C P GG +C C G L ++ K C
Sbjct: 164 MNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDC 202
>CR457140-1|CAG33421.1| 448|Homo sapiens FBLN5 protein.
Length = 448
Score = 81.0 bits (191), Expect = 4e-14
Identities = 50/171 (29%), Positives = 70/171 (40%), Gaps = 12/171 (7%)
Query: 353 CAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ-----EHLMSNAFRNCV 406
C D C + C+ + C N E C SC + + Q E + C
Sbjct: 125 CVDVDECATDSHQCNPTQICINTEGGYTC--SCTDGYWLLEGQCLDIDECRYGYCQQLCA 182
Query: 407 N--RKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAED 464
N + C +D C +C+ E C + C+ TY G C C G+ L ED
Sbjct: 183 NVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTY-GSFICRCDPGYELEED 241
Query: 465 KYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C D+DEC + + +C C N G++ C C GYIL D RSC+ E
Sbjct: 242 GVHCSDMDECSFSEF-LCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINE 291
Score = 67.3 bits (157), Expect = 5e-10
Identities = 36/100 (36%), Positives = 52/100 (52%), Gaps = 9/100 (9%)
Query: 422 DDEERCPLKRKCSAEE-KCE--KLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQ 478
D+ +C +C+ + +C ++CI T G+ C+C G+ L E + C DIDEC Y
Sbjct: 120 DESNQCVDVDECATDSHQCNPTQICINTEGGYT-CSCTDGYWLLEGQ--CLDIDECRYGY 176
Query: 479 DPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPT 518
C Q C+N GS+ C C G+ L D RSC+ E T
Sbjct: 177 ---CQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECAT 213
Score = 65.3 bits (152), Expect = 2e-09
Identities = 64/235 (27%), Positives = 96/235 (40%), Gaps = 36/235 (15%)
Query: 311 CNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDG--- 367
C G + E +C + +CA D C P I + YTC+ C WL +G
Sbjct: 113 CRFGYQMDESNQCVDVDECAT--DSHQCNPTQICINTEGGYTCS---CTDGYWLLEGQCL 167
Query: 368 -VRDCTNGEDEMNC-----EVSC--------EEDQYTCRPQEHLMSN--AFRNCVNR--K 409
+ +C G + C SC ED +C+ + + CVN
Sbjct: 168 DIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGS 227
Query: 410 HVCDGMKDCPRGDDEERCPLKRKCSAEE-KCEKLCITTYDGHAACACPMGFLLAEDKYSC 468
+C +D C +CS E C+ C+ G C+CP G++L +D SC
Sbjct: 228 FICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQ-PGTYFCSCPPGYILLDDNRSC 286
Query: 469 RDIDECMYEQDPVCS--QTCSNTVGSFRC----GCMTGYILRPDERSCKPTGESP 517
+DI+EC + ++ C+ QTC N G F+C C Y LR + C E+P
Sbjct: 287 QDINECEH-RNHTCNLQQTCYNLQGGFKCIDPIRCEEPY-LRISDNRCMCPAENP 339
Score = 41.1 bits (92), Expect = 0.035
Identities = 16/33 (48%), Positives = 19/33 (57%)
Query: 1024 GGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
G C LC PG SC C G LN+DG++C D
Sbjct: 175 GYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQD 207
Score = 35.1 bits (77), Expect = 2.3
Identities = 13/31 (41%), Positives = 18/31 (58%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C H C+ +PG C+CP G L D ++C D
Sbjct: 258 CQHECVNQPGTYFCSCPPGYILLDDNRSCQD 288
>BC052263-1|AAH52263.2| 992|Homo sapiens signal peptide, CUB
domain, EGF-like 3 protein.
Length = 992
Score = 81.0 bits (191), Expect = 4e-14
Identities = 85/292 (29%), Positives = 118/292 (40%), Gaps = 55/292 (18%)
Query: 266 IDFECKNT----KCVPKD-FQCDGDN--DCGDWTDEDSCPMVPGSCNA-GEFKCN--DGK 315
ID C+NT KC+ K + DG + D + ED+ V N G ++C DG
Sbjct: 42 IDAICQNTPRSYKCICKSGYTGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGF 101
Query: 316 CIP-ERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNG 374
+ + C + +CA+G C+ + + + Y C C +L D C
Sbjct: 102 HLAHDGHNCLDVDECAEGNG--GCQQSCVN--MMGSYEC---HCREGFFLSDNQHTCIQR 154
Query: 375 EDEMNCEVS-------CEEDQY-----TCRPQEHLMSNAFRNCV--------NRKHVCDG 414
+ MNC C E CRP L N R+C +H CD
Sbjct: 155 PEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQ-RDCKLTCNYGNGGCQHTCDD 213
Query: 415 MKDCPRGDDEERCPLKRKCSAEEK-CEKLCITTYDG-----HAA-----CACPMGFLLAE 463
+ PR C +K + K C + C G H A C CP+GF+L
Sbjct: 214 TEQGPRCG----CHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAAIGVHCTCPVGFMLQP 269
Query: 464 DKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
D+ +C+DIDEC C C NTVGSF C C GY L +ER+C+ E
Sbjct: 270 DRKTCKDIDECRLNNGG-CDHICRNTVGSFECSCKKGYKLLINERNCQDIDE 320
Score = 63.7 bits (148), Expect = 6e-09
Identities = 69/253 (27%), Positives = 100/253 (39%), Gaps = 38/253 (15%)
Query: 275 CVPKDFQCDGDNDCGDWTDEDSCPMVPGS----CNAGEFKC-NDGKCI--PERWRCDNE- 326
C+ D +G+ C + SC + GS C G F N CI PE C N+
Sbjct: 110 CLDVDECAEGNGGC-----QQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEGMNCMNKN 164
Query: 327 -------RDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMN 379
R+ GG C+P + ++ C C C D T
Sbjct: 165 HGCAHICRETPKGGIACECRPGF--ELTKNQRDCK-LTCNYGNGGCQHTCDDTEQGPRCG 221
Query: 380 CEVS--CEEDQYTCRPQEHLMSNAFRNCVNRKH-VCDGMK-DCPRG----DDEERCPLKR 431
C + D TC + ++N C ++ H G+ CP G D + C
Sbjct: 222 CHIKFVLHTDGKTCI-ETCAVNNG--GCDSKCHDAAIGVHCTCPVGFMLQPDRKTCKDID 278
Query: 432 KCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTV 490
+C C+ +C T G C+C G+ L ++ +C+DIDEC + D C C NT
Sbjct: 279 ECRLNNGGCDHICRNTV-GSFECSCKKGYKLLINERNCQDIDECSF--DRTCDHICVNTP 335
Query: 491 GSFRCGCMTGYIL 503
GSF+C C GY+L
Sbjct: 336 GSFQCLCHRGYLL 348
Score = 59.3 bits (137), Expect = 1e-07
Identities = 50/186 (26%), Positives = 76/186 (40%), Gaps = 15/186 (8%)
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDG-VRDCTNGEDEMNCE 381
C + D + G C + + D TC + C + CD D G C
Sbjct: 207 CQHTCDDTEQGPRCGCHIKFVLHT--DGKTCIET-CAVNNGGCDSKCHDAAIGV-HCTCP 262
Query: 382 VS--CEEDQYTCRP-QEHLMSNAFRNCVNRKHVCDGMKDCPRGD----DEERCPLKRKCS 434
V + D+ TC+ E ++N + + R V C +G +E C +CS
Sbjct: 263 VGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECS 322
Query: 435 AEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFR 494
+ C+ +C+ T G C C G+LL + C D+DEC + C C NT GS++
Sbjct: 323 FDRTCDHICVNT-PGSFQCLCHRGYLLYGITH-CGDVDECSINRGG-CRFGCINTPGSYQ 379
Query: 495 CGCMTG 500
C C G
Sbjct: 380 CTCPAG 385
Score = 44.0 bits (99), Expect = 0.005
Identities = 18/38 (47%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NNGGC C G C CP+G L D KTC D
Sbjct: 239 CAVNNGGCDSKCHDAAIGVHCTCPVGFMLQPDRKTCKD 276
Score = 42.3 bits (95), Expect = 0.015
Identities = 18/40 (45%), Positives = 20/40 (50%)
Query: 1017 LGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
L C NGGC H C G C C I L+ DGKTC +
Sbjct: 198 LTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIE 237
Score = 40.3 bits (90), Expect = 0.061
Identities = 16/38 (42%), Positives = 20/38 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NNGGC H+C G C+C G KL + + C D
Sbjct: 280 CRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQD 317
Score = 39.1 bits (87), Expect = 0.14
Identities = 16/39 (41%), Positives = 21/39 (53%), Gaps = 1/39 (2%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGI-KLNKDGKTCAD 1056
C N GGC C+ PG C CP G +L+ +GK C +
Sbjct: 360 CSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTE 398
Score = 37.9 bits (84), Expect = 0.33
Identities = 15/39 (38%), Positives = 22/39 (56%), Gaps = 1/39 (2%)
Query: 1017 LGCGKNNGGCSHLCLLKP-GGRSCACPIGIKLNKDGKTC 1054
+ C N GC+H+C P GG +C C G +L K+ + C
Sbjct: 158 MNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDC 196
Score = 37.1 bits (82), Expect = 0.57
Identities = 15/36 (41%), Positives = 18/36 (50%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
++N GC H C+ PG C C G L DG C D
Sbjct: 77 EDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLD 112
Score = 36.7 bits (81), Expect = 0.76
Identities = 17/47 (36%), Positives = 22/47 (46%), Gaps = 2/47 (4%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTGM-PFEKSTTDQT-PKKCKSHP 1366
C + GGC C+ +P Y C CP G + D T P KC+ P
Sbjct: 360 CSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSP 406
Score = 35.1 bits (77), Expect = 2.3
Identities = 14/40 (35%), Positives = 18/40 (45%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGP 1058
C + NGGC C+ G C C G L+ + TC P
Sbjct: 116 CAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRP 155
Score = 33.9 bits (74), Expect = 5.3
Identities = 11/26 (42%), Positives = 14/26 (53%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTG 1347
C +NGGC C + +G C CP G
Sbjct: 239 CAVNNGGCDSKCHDAAIGVHCTCPVG 264
>BC022280-1|AAH22280.1| 448|Homo sapiens fibulin 5 protein.
Length = 448
Score = 81.0 bits (191), Expect = 4e-14
Identities = 50/171 (29%), Positives = 70/171 (40%), Gaps = 12/171 (7%)
Query: 353 CAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ-----EHLMSNAFRNCV 406
C D C + C+ + C N E C SC + + Q E + C
Sbjct: 125 CVDVDECATDSHQCNPTQICINTEGGYTC--SCTDGYWLLEGQCLDIDECRYGYCQQLCA 182
Query: 407 N--RKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAED 464
N + C +D C +C+ E C + C+ TY G C C G+ L ED
Sbjct: 183 NVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTY-GSFICRCDPGYELEED 241
Query: 465 KYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C D+DEC + + +C C N G++ C C GYIL D RSC+ E
Sbjct: 242 GVHCSDMDECSFSEF-LCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINE 291
Score = 67.3 bits (157), Expect = 5e-10
Identities = 36/100 (36%), Positives = 52/100 (52%), Gaps = 9/100 (9%)
Query: 422 DDEERCPLKRKCSAEE-KCE--KLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQ 478
D+ +C +C+ + +C ++CI T G+ C+C G+ L E + C DIDEC Y
Sbjct: 120 DESNQCVDVDECATDSHQCNPTQICINTEGGYT-CSCTDGYWLLEGQ--CLDIDECRYGY 176
Query: 479 DPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPT 518
C Q C+N GS+ C C G+ L D RSC+ E T
Sbjct: 177 ---CQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECAT 213
Score = 65.3 bits (152), Expect = 2e-09
Identities = 64/235 (27%), Positives = 96/235 (40%), Gaps = 36/235 (15%)
Query: 311 CNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDG--- 367
C G + E +C + +CA D C P I + YTC+ C WL +G
Sbjct: 113 CRFGYQMDESNQCVDVDECAT--DSHQCNPTQICINTEGGYTCS---CTDGYWLLEGQCL 167
Query: 368 -VRDCTNGEDEMNC-----EVSC--------EEDQYTCRPQEHLMSN--AFRNCVNR--K 409
+ +C G + C SC ED +C+ + + CVN
Sbjct: 168 DIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGS 227
Query: 410 HVCDGMKDCPRGDDEERCPLKRKCSAEE-KCEKLCITTYDGHAACACPMGFLLAEDKYSC 468
+C +D C +CS E C+ C+ G C+CP G++L +D SC
Sbjct: 228 FICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQ-PGTYFCSCPPGYILLDDNRSC 286
Query: 469 RDIDECMYEQDPVCS--QTCSNTVGSFRC----GCMTGYILRPDERSCKPTGESP 517
+DI+EC + ++ C+ QTC N G F+C C Y LR + C E+P
Sbjct: 287 QDINECEH-RNHTCNLQQTCYNLQGGFKCIDPIRCEEPY-LRISDNRCMCPAENP 339
Score = 41.1 bits (92), Expect = 0.035
Identities = 16/33 (48%), Positives = 19/33 (57%)
Query: 1024 GGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
G C LC PG SC C G LN+DG++C D
Sbjct: 175 GYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQD 207
Score = 35.1 bits (77), Expect = 2.3
Identities = 13/31 (41%), Positives = 18/31 (58%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C H C+ +PG C+CP G L D ++C D
Sbjct: 258 CQHECVNQPGTYFCSCPPGYILLDDNRSCQD 288
>AJ133490-1|CAB38568.1| 448|Homo sapiens fibulin-5 protein.
Length = 448
Score = 81.0 bits (191), Expect = 4e-14
Identities = 50/171 (29%), Positives = 70/171 (40%), Gaps = 12/171 (7%)
Query: 353 CAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ-----EHLMSNAFRNCV 406
C D C + C+ + C N E C SC + + Q E + C
Sbjct: 125 CVDVDECATDSHQCNPTQICINTEGGYTC--SCTDGYWLLEGQCLDIDECRYGYCQQLCA 182
Query: 407 N--RKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAED 464
N + C +D C +C+ E C + C+ TY G C C G+ L ED
Sbjct: 183 NVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTY-GSFICRCDPGYELEED 241
Query: 465 KYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C D+DEC + + +C C N G++ C C GYIL D RSC+ E
Sbjct: 242 GVHCSDMDECSFSEF-LCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINE 291
Score = 67.3 bits (157), Expect = 5e-10
Identities = 36/100 (36%), Positives = 52/100 (52%), Gaps = 9/100 (9%)
Query: 422 DDEERCPLKRKCSAEE-KCE--KLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQ 478
D+ +C +C+ + +C ++CI T G+ C+C G+ L E + C DIDEC Y
Sbjct: 120 DESNQCVDVDECATDSHQCNPTQICINTEGGYT-CSCTDGYWLLEGQ--CLDIDECRYGY 176
Query: 479 DPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPT 518
C Q C+N GS+ C C G+ L D RSC+ E T
Sbjct: 177 ---CQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECAT 213
Score = 65.3 bits (152), Expect = 2e-09
Identities = 64/235 (27%), Positives = 96/235 (40%), Gaps = 36/235 (15%)
Query: 311 CNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDG--- 367
C G + E +C + +CA D C P I + YTC+ C WL +G
Sbjct: 113 CRFGYQMDESNQCVDVDECAT--DSHQCNPTQICINTEGGYTCS---CTDGYWLLEGQCL 167
Query: 368 -VRDCTNGEDEMNC-----EVSC--------EEDQYTCRPQEHLMSN--AFRNCVNR--K 409
+ +C G + C SC ED +C+ + + CVN
Sbjct: 168 DIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGS 227
Query: 410 HVCDGMKDCPRGDDEERCPLKRKCSAEE-KCEKLCITTYDGHAACACPMGFLLAEDKYSC 468
+C +D C +CS E C+ C+ G C+CP G++L +D SC
Sbjct: 228 FICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQ-PGTYFCSCPPGYILLDDNRSC 286
Query: 469 RDIDECMYEQDPVCS--QTCSNTVGSFRC----GCMTGYILRPDERSCKPTGESP 517
+DI+EC + ++ C+ QTC N G F+C C Y LR + C E+P
Sbjct: 287 QDINECEH-RNHTCNLQQTCYNLQGGFKCIDPIRCEEPY-LRISDNRCMCPAENP 339
Score = 41.1 bits (92), Expect = 0.035
Identities = 16/33 (48%), Positives = 19/33 (57%)
Query: 1024 GGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
G C LC PG SC C G LN+DG++C D
Sbjct: 175 GYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQD 207
Score = 35.1 bits (77), Expect = 2.3
Identities = 13/31 (41%), Positives = 18/31 (58%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C H C+ +PG C+CP G L D ++C D
Sbjct: 258 CQHECVNQPGTYFCSCPPGYILLDDNRSCQD 288
>AF112152-1|AAD41768.1| 448|Homo sapiens developmental arteries and
neural crest EGF-like protein protein.
Length = 448
Score = 81.0 bits (191), Expect = 4e-14
Identities = 50/171 (29%), Positives = 70/171 (40%), Gaps = 12/171 (7%)
Query: 353 CAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ-----EHLMSNAFRNCV 406
C D C + C+ + C N E C SC + + Q E + C
Sbjct: 125 CVDVDECATDSHQCNPTQICINTEGGYTC--SCTDGYWLLEGQCLDIDECRYGYCQQLCA 182
Query: 407 N--RKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAED 464
N + C +D C +C+ E C + C+ TY G C C G+ L ED
Sbjct: 183 NVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTY-GSFICRCDPGYELEED 241
Query: 465 KYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C D+DEC + + +C C N G++ C C GYIL D RSC+ E
Sbjct: 242 GVHCSDMDECSFSEF-LCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINE 291
Score = 67.3 bits (157), Expect = 5e-10
Identities = 36/100 (36%), Positives = 52/100 (52%), Gaps = 9/100 (9%)
Query: 422 DDEERCPLKRKCSAEE-KCE--KLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQ 478
D+ +C +C+ + +C ++CI T G+ C+C G+ L E + C DIDEC Y
Sbjct: 120 DESNQCVDVDECATDSHQCNPTQICINTEGGYT-CSCTDGYWLLEGQ--CLDIDECRYGY 176
Query: 479 DPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPT 518
C Q C+N GS+ C C G+ L D RSC+ E T
Sbjct: 177 ---CQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECAT 213
Score = 65.3 bits (152), Expect = 2e-09
Identities = 64/235 (27%), Positives = 96/235 (40%), Gaps = 36/235 (15%)
Query: 311 CNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDG--- 367
C G + E +C + +CA D C P I + YTC+ C WL +G
Sbjct: 113 CRFGYQMDESNQCVDVDECAT--DSHQCNPTQICINTEGGYTCS---CTDGYWLLEGQCL 167
Query: 368 -VRDCTNGEDEMNC-----EVSC--------EEDQYTCRPQEHLMSN--AFRNCVNR--K 409
+ +C G + C SC ED +C+ + + CVN
Sbjct: 168 DIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGS 227
Query: 410 HVCDGMKDCPRGDDEERCPLKRKCSAEE-KCEKLCITTYDGHAACACPMGFLLAEDKYSC 468
+C +D C +CS E C+ C+ G C+CP G++L +D SC
Sbjct: 228 FICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQ-PGTYFCSCPPGYILLDDNRSC 286
Query: 469 RDIDECMYEQDPVCS--QTCSNTVGSFRC----GCMTGYILRPDERSCKPTGESP 517
+DI+EC + ++ C+ QTC N G F+C C Y LR + C E+P
Sbjct: 287 QDINECEH-RNHTCNLQQTCYNLQGGFKCIDPIRCEEPY-LRISDNRCMCPAENP 339
Score = 41.1 bits (92), Expect = 0.035
Identities = 16/33 (48%), Positives = 19/33 (57%)
Query: 1024 GGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
G C LC PG SC C G LN+DG++C D
Sbjct: 175 GYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQD 207
Score = 35.1 bits (77), Expect = 2.3
Identities = 13/31 (41%), Positives = 18/31 (58%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C H C+ +PG C+CP G L D ++C D
Sbjct: 258 CQHECVNQPGTYFCSCPPGYILLDDNRSCQD 288
>BC127263-1|AAI27264.1| 363|Homo sapiens SCUBE1 protein protein.
Length = 363
Score = 80.6 bits (190), Expect = 5e-14
Identities = 73/261 (27%), Positives = 110/261 (42%), Gaps = 38/261 (14%)
Query: 269 ECKNTKCVPKDFQC---DG---DNDCGDWTDEDSCPMVPGSC-----NA-GEFKCNDGKC 316
EC N +P +++C DG +D + D D C G C NA G ++C +C
Sbjct: 90 ECIN---IPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYEC---QC 143
Query: 317 IPERWRCDNERDCADGGDE-LNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGE 375
+ DN+ C +E +NC N C+ + C R CD +
Sbjct: 144 HSGFFLSDNQHTCIHRSNEGMNCM-NKDHGCA---HIC--RETPKGGVACDCRPGFDLAQ 197
Query: 376 DEMNCEVSCEEDQYTCRPQ-EHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCS 434
++ +C ++C C+ E + C + + + C E C +
Sbjct: 198 NQKDCTLTCNYGNGGCQHSCEDTDTGPMCGCHQKYALHSDGRTCI-----ETCAVNNG-- 250
Query: 435 AEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFR 494
C++ C T G C+CP+GF L D +C+DI+EC+ C C NTVGSF
Sbjct: 251 ---GCDRTCKDTATG-VRCSCPVGFTLQPDGKTCKDINECLVNNGG-CDHFCRNTVGSFE 305
Query: 495 CGCMTGYILRPDERSCKPTGE 515
CGC GY L DER+C+ E
Sbjct: 306 CGCRKGYKLLTDERTCQDIDE 326
Score = 64.1 bits (149), Expect = 4e-09
Identities = 27/72 (37%), Positives = 41/72 (56%), Gaps = 2/72 (2%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCM 498
C CI G+ C C GF+LA D ++C D+DEC + + C Q C N +GS+ C C
Sbjct: 87 CVHECINI-PGNYRCTCFDGFMLAHDGHNCLDVDECQ-DNNGGCQQICVNAMGSYECQCH 144
Query: 499 TGYILRPDERSC 510
+G+ L ++ +C
Sbjct: 145 SGFFLSDNQHTC 156
Score = 49.6 bits (113), Expect = 1e-04
Identities = 19/38 (50%), Positives = 21/38 (55%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NNGGC C G C+CP+G L DGKTC D
Sbjct: 245 CAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKD 282
Score = 44.8 bits (101), Expect = 0.003
Identities = 23/64 (35%), Positives = 31/64 (48%), Gaps = 3/64 (4%)
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQ-DPVCSQTCSNTVGSFRCGCMTGYILRPDERSCK 511
C C G+ E K C DIDEC + + C C N G++RC C G++L D +C
Sbjct: 59 CLCKPGYK-GEGK-QCEDIDECENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCL 116
Query: 512 PTGE 515
E
Sbjct: 117 DVDE 120
Score = 42.7 bits (96), Expect = 0.012
Identities = 18/38 (47%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NNGGC H C G C C G KL D +TC D
Sbjct: 286 CLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQD 323
Score = 40.7 bits (91), Expect = 0.046
Identities = 17/41 (41%), Positives = 20/41 (48%)
Query: 1016 TLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
TL C NGGC H C G C C L+ DG+TC +
Sbjct: 203 TLTCNYGNGGCQHSCEDTDTGPMCGCHQKYALHSDGRTCIE 243
Score = 39.1 bits (87), Expect = 0.14
Identities = 16/34 (47%), Positives = 17/34 (50%)
Query: 1023 NGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
NGGC H C+ PG C C G L DG C D
Sbjct: 84 NGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLD 117
Score = 36.7 bits (81), Expect = 0.76
Identities = 14/36 (38%), Positives = 18/36 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C NNGGC +C+ G C C G L+ + TC
Sbjct: 121 CQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTC 156
Score = 35.9 bits (79), Expect = 1.3
Identities = 14/42 (33%), Positives = 20/42 (47%), Gaps = 1/42 (2%)
Query: 1311 AIQSE-RVLENACGTDNGGCSHLCLRSPLGYTCACPTGMPFE 1351
A+ S+ R C +NGGC C + G C+CP G +
Sbjct: 233 ALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQ 274
Score = 33.5 bits (73), Expect = 7.0
Identities = 14/39 (35%), Positives = 21/39 (53%), Gaps = 1/39 (2%)
Query: 1017 LGCGKNNGGCSHLCLLKP-GGRSCACPIGIKLNKDGKTC 1054
+ C + GC+H+C P GG +C C G L ++ K C
Sbjct: 164 MNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDC 202
>BC007408-1|AAH07408.1| 770|Homo sapiens low density lipoprotein
receptor-related protein 3 protein.
Length = 770
Score = 80.2 bits (189), Expect = 6e-14
Identities = 37/108 (34%), Positives = 50/108 (46%), Gaps = 11/108 (10%)
Query: 275 CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK--CIPERWRCDNERDCADG 332
C + +CDG C DE CP +C ++ C G C RC+N++ C DG
Sbjct: 391 CFSEPQRCDGWWHCASGRDEQGCP----ACPPDQYPCEGGSGLCYTPADRCNNQKSCPDG 446
Query: 333 GDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC 380
DE NC +C + C C+ +TW CDG DC +G DE C
Sbjct: 447 ADEKNCF-----SCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489
Score = 73.7 bits (173), Expect = 5e-12
Identities = 35/92 (38%), Positives = 52/92 (56%), Gaps = 12/92 (13%)
Query: 303 SCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCK------PNSIRNCSLDEYTCA-- 354
SC A EF+C++GKC+P W+C+ +C DG DE NC P S+ C + C+
Sbjct: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSL--CPGGTFPCSGA 222
Query: 355 -DRRCVLKTWLCDGVRDCTNGEDEMNC-EVSC 384
RC+ CDG++DC +G DE C +++C
Sbjct: 223 RSTRCLPVERRCDGLQDCGDGSDEAGCPDLAC 254
Score = 73.3 bits (172), Expect = 7e-12
Identities = 34/84 (40%), Positives = 46/84 (54%), Gaps = 8/84 (9%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPM----VPGS-CNAGEFKCNDG--- 314
C +F C N KC+P +QC+ ++CGD +DE +C PGS C G F C+
Sbjct: 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARST 225
Query: 315 KCIPERWRCDNERDCADGGDELNC 338
+C+P RCD +DC DG DE C
Sbjct: 226 RCLPVERRCDGLQDCGDGSDEAGC 249
Score = 62.9 bits (146), Expect = 1e-08
Identities = 28/86 (32%), Positives = 43/86 (50%), Gaps = 2/86 (2%)
Query: 345 NCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRN 404
+C DE+ C + +C+ W C+ V +C +G DE NC E + P + R+
Sbjct: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARS 224
Query: 405 --CVNRKHVCDGMKDCPRGDDEERCP 428
C+ + CDG++DC G DE CP
Sbjct: 225 TRCLPVERRCDGLQDCGDGSDEAGCP 250
Score = 60.9 bits (141), Expect = 4e-08
Identities = 28/78 (35%), Positives = 34/78 (43%), Gaps = 6/78 (7%)
Query: 263 CAEIDFECKNTK--CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPER 320
C + C+ C +C+ C D DE +C SC G F C CI E
Sbjct: 416 CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNC----FSCQPGTFHCGTNLCIFET 471
Query: 321 WRCDNERDCADGGDELNC 338
WRCD + DC DG DE C
Sbjct: 472 WRCDGQEDCQDGSDEHGC 489
Score = 59.3 bits (137), Expect = 1e-07
Identities = 38/117 (32%), Positives = 47/117 (40%), Gaps = 17/117 (14%)
Query: 313 DGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTC--ADRRCVLKTWLCDGVRD 370
D C E RCD CA G DE C C D+Y C C C+ +
Sbjct: 388 DQGCFSEPQRCDGWWHCASGRDEQGCPA-----CPPDQYPCEGGSGLCYTPADRCNNQKS 442
Query: 371 CTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC 427
C +G DE NC SC+ + C +N C+ CDG +DC G DE C
Sbjct: 443 CPDGADEKNC-FSCQPGTFHCG------TNL---CIFETWRCDGQEDCQDGSDEHGC 489
Score = 48.4 bits (110), Expect = 2e-04
Identities = 26/79 (32%), Positives = 33/79 (41%), Gaps = 8/79 (10%)
Query: 349 DEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNR 408
D + D+ C + CDG C +G DE C +C DQY C L C
Sbjct: 382 DGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCP-ACPPDQYPCEGGSGL-------CYTP 433
Query: 409 KHVCDGMKDCPRGDDEERC 427
C+ K CP G DE+ C
Sbjct: 434 ADRCNNQKSCPDGADEKNC 452
Score = 42.3 bits (95), Expect = 0.015
Identities = 16/39 (41%), Positives = 24/39 (61%)
Query: 271 KNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEF 309
++T+C+P + +CDG DCGD +DE CP + G F
Sbjct: 223 RSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSF 261
Score = 40.3 bits (90), Expect = 0.061
Identities = 23/71 (32%), Positives = 34/71 (47%), Gaps = 4/71 (5%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
++C + T TN+CI W CDG DC D SDE C ++ +A IG
Sbjct: 450 KNCFSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLAAVPRKVITAA----LIGS 505
Query: 216 VITNPTVLIAL 226
++ ++IAL
Sbjct: 506 LVCGLLLVIAL 516
Score = 34.3 bits (75), Expect = 4.0
Identities = 13/23 (56%), Positives = 15/23 (65%)
Query: 173 CIALEWLCDGDNDCGDFSDEINC 195
C+ +E CDG DCGD SDE C
Sbjct: 227 CLPVERRCDGLQDCGDGSDEAGC 249
>AB009462-1|BAA32330.1| 770|Homo sapiens LDL receptor related
protein 105 protein.
Length = 770
Score = 80.2 bits (189), Expect = 6e-14
Identities = 37/108 (34%), Positives = 50/108 (46%), Gaps = 11/108 (10%)
Query: 275 CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK--CIPERWRCDNERDCADG 332
C + +CDG C DE CP +C ++ C G C RC+N++ C DG
Sbjct: 391 CFSEPQRCDGWWHCASGRDEQGCP----ACPPDQYPCEGGSGLCYTPADRCNNQKSCPDG 446
Query: 333 GDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC 380
DE NC +C + C C+ +TW CDG DC +G DE C
Sbjct: 447 ADEKNCF-----SCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489
Score = 73.7 bits (173), Expect = 5e-12
Identities = 35/92 (38%), Positives = 52/92 (56%), Gaps = 12/92 (13%)
Query: 303 SCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCK------PNSIRNCSLDEYTCA-- 354
SC A EF+C++GKC+P W+C+ +C DG DE NC P S+ C + C+
Sbjct: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSL--CPGGTFPCSGA 222
Query: 355 -DRRCVLKTWLCDGVRDCTNGEDEMNC-EVSC 384
RC+ CDG++DC +G DE C +++C
Sbjct: 223 RSTRCLPVERRCDGLQDCGDGSDEAGCPDLAC 254
Score = 73.3 bits (172), Expect = 7e-12
Identities = 34/84 (40%), Positives = 46/84 (54%), Gaps = 8/84 (9%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPM----VPGS-CNAGEFKCNDG--- 314
C +F C N KC+P +QC+ ++CGD +DE +C PGS C G F C+
Sbjct: 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARST 225
Query: 315 KCIPERWRCDNERDCADGGDELNC 338
+C+P RCD +DC DG DE C
Sbjct: 226 RCLPVERRCDGLQDCGDGSDEAGC 249
Score = 62.9 bits (146), Expect = 1e-08
Identities = 28/86 (32%), Positives = 43/86 (50%), Gaps = 2/86 (2%)
Query: 345 NCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRN 404
+C DE+ C + +C+ W C+ V +C +G DE NC E + P + R+
Sbjct: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARS 224
Query: 405 --CVNRKHVCDGMKDCPRGDDEERCP 428
C+ + CDG++DC G DE CP
Sbjct: 225 TRCLPVERRCDGLQDCGDGSDEAGCP 250
Score = 60.9 bits (141), Expect = 4e-08
Identities = 28/78 (35%), Positives = 34/78 (43%), Gaps = 6/78 (7%)
Query: 263 CAEIDFECKNTK--CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPER 320
C + C+ C +C+ C D DE +C SC G F C CI E
Sbjct: 416 CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNC----FSCQPGTFHCGTNLCIFET 471
Query: 321 WRCDNERDCADGGDELNC 338
WRCD + DC DG DE C
Sbjct: 472 WRCDGQEDCQDGSDEHGC 489
Score = 59.3 bits (137), Expect = 1e-07
Identities = 38/117 (32%), Positives = 47/117 (40%), Gaps = 17/117 (14%)
Query: 313 DGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTC--ADRRCVLKTWLCDGVRD 370
D C E RCD CA G DE C C D+Y C C C+ +
Sbjct: 388 DQGCFSEPQRCDGWWHCASGRDEQGCPA-----CPPDQYPCEGGSGLCYTPADRCNNQKS 442
Query: 371 CTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC 427
C +G DE NC SC+ + C +N C+ CDG +DC G DE C
Sbjct: 443 CPDGADEKNC-FSCQPGTFHCG------TNL---CIFETWRCDGQEDCQDGSDEHGC 489
Score = 48.4 bits (110), Expect = 2e-04
Identities = 26/79 (32%), Positives = 33/79 (41%), Gaps = 8/79 (10%)
Query: 349 DEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNR 408
D + D+ C + CDG C +G DE C +C DQY C L C
Sbjct: 382 DGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCP-ACPPDQYPCEGGSGL-------CYTP 433
Query: 409 KHVCDGMKDCPRGDDEERC 427
C+ K CP G DE+ C
Sbjct: 434 ADRCNNQKSCPDGADEKNC 452
Score = 42.3 bits (95), Expect = 0.015
Identities = 16/39 (41%), Positives = 24/39 (61%)
Query: 271 KNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEF 309
++T+C+P + +CDG DCGD +DE CP + G F
Sbjct: 223 RSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSF 261
Score = 40.3 bits (90), Expect = 0.061
Identities = 23/71 (32%), Positives = 34/71 (47%), Gaps = 4/71 (5%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
++C + T TN+CI W CDG DC D SDE C ++ +A IG
Sbjct: 450 KNCFSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLAAVPRKVITAA----LIGS 505
Query: 216 VITNPTVLIAL 226
++ ++IAL
Sbjct: 506 LVCGLLLVIAL 516
Score = 34.3 bits (75), Expect = 4.0
Identities = 13/23 (56%), Positives = 15/23 (65%)
Query: 173 CIALEWLCDGDNDCGDFSDEINC 195
C+ +E CDG DCGD SDE C
Sbjct: 227 CLPVERRCDGLQDCGDGSDEAGC 249
>Z99756-1|CAI18854.1| 988|Homo sapiens protein ( Human DNA sequence
from clone RP1-100N22 on chromosome 22q13.31-13.33. ).
Length = 988
Score = 79.8 bits (188), Expect = 8e-14
Identities = 73/261 (27%), Positives = 110/261 (42%), Gaps = 38/261 (14%)
Query: 269 ECKNTKCVPKDFQC---DG---DNDCGDWTDEDSCPMVPGSC-----NA-GEFKCNDGKC 316
EC N +P +++C DG +D + D D C G C NA G ++C +C
Sbjct: 90 ECIN---IPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYEC---QC 143
Query: 317 IPERWRCDNERDCADGGDE-LNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGE 375
+ DN+ C +E +NC N C+ + C R CD +
Sbjct: 144 HSGFFLSDNQHTCIHRSNEGMNCM-NKDHGCA---HIC--RETPKGGVACDCRPGFDLAQ 197
Query: 376 DEMNCEVSCEEDQYTCRPQ-EHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCS 434
++ +C ++C C+ E + C + + + C E C +
Sbjct: 198 NQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCI-----ETCAVNNG-- 250
Query: 435 AEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFR 494
C++ C T G C+CP+GF L D +C+DI+EC+ C C NTVGSF
Sbjct: 251 ---GCDRTCKDTATG-VRCSCPVGFTLQPDGKTCKDINECLVNNGG-CDHFCRNTVGSFE 305
Query: 495 CGCMTGYILRPDERSCKPTGE 515
CGC GY L DER+C+ E
Sbjct: 306 CGCRKGYKLLTDERTCQDIDE 326
Score = 69.3 bits (162), Expect = 1e-10
Identities = 56/200 (28%), Positives = 81/200 (40%), Gaps = 13/200 (6%)
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV 382
C + + D G C + D TC + C + CD T +C V
Sbjct: 213 CQHSCEDTDTGPTCGCHQKYALHS--DGRTCIET-CAVNNGGCDRTCKDTATGVRCSCPV 269
Query: 383 --SCEEDQYTCRP-QEHLMSNAFRNCVNRKHVCDGMKDCPRG----DDEERCPLKRKCSA 435
+ + D TC+ E L++N + R V C +G DE C +CS
Sbjct: 270 GFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSF 329
Query: 436 EEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRC 495
E C+ +CI + G C C G++L + C D+DEC C Q C NT GS+ C
Sbjct: 330 ERTCDHICINS-PGSFQCLCHRGYILYGTTH-CGDVDECSMSNGS-CDQGCVNTKGSYEC 386
Query: 496 GCMTGYILRPDERSCKPTGE 515
C G L + + C TG+
Sbjct: 387 VCPPGRRLHWNGKDCVETGK 406
Score = 64.1 bits (149), Expect = 4e-09
Identities = 27/72 (37%), Positives = 41/72 (56%), Gaps = 2/72 (2%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCM 498
C CI G+ C C GF+LA D ++C D+DEC + + C Q C N +GS+ C C
Sbjct: 87 CVHECINI-PGNYRCTCFDGFMLAHDGHNCLDVDECQ-DNNGGCQQICVNAMGSYECQCH 144
Query: 499 TGYILRPDERSC 510
+G+ L ++ +C
Sbjct: 145 SGFFLSDNQHTC 156
Score = 49.6 bits (113), Expect = 1e-04
Identities = 19/38 (50%), Positives = 21/38 (55%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NNGGC C G C+CP+G L DGKTC D
Sbjct: 245 CAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKD 282
Score = 44.8 bits (101), Expect = 0.003
Identities = 23/64 (35%), Positives = 31/64 (48%), Gaps = 3/64 (4%)
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQ-DPVCSQTCSNTVGSFRCGCMTGYILRPDERSCK 511
C C G+ E K C DIDEC + + C C N G++RC C G++L D +C
Sbjct: 59 CLCKPGYK-GEGK-QCEDIDECENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCL 116
Query: 512 PTGE 515
E
Sbjct: 117 DVDE 120
Score = 42.7 bits (96), Expect = 0.012
Identities = 18/38 (47%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NNGGC H C G C C G KL D +TC D
Sbjct: 286 CLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQD 323
Score = 41.5 bits (93), Expect = 0.027
Identities = 17/41 (41%), Positives = 21/41 (51%)
Query: 1016 TLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
TL C NGGC H C G +C C L+ DG+TC +
Sbjct: 203 TLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIE 243
Score = 39.1 bits (87), Expect = 0.14
Identities = 16/34 (47%), Positives = 17/34 (50%)
Query: 1023 NGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
NGGC H C+ PG C C G L DG C D
Sbjct: 84 NGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLD 117
Score = 38.7 bits (86), Expect = 0.19
Identities = 14/38 (36%), Positives = 20/38 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C +NG C C+ G C CP G +L+ +GK C +
Sbjct: 366 CSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVE 403
Score = 36.7 bits (81), Expect = 0.76
Identities = 14/36 (38%), Positives = 18/36 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C NNGGC +C+ G C C G L+ + TC
Sbjct: 121 CQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTC 156
Score = 35.9 bits (79), Expect = 1.3
Identities = 14/42 (33%), Positives = 20/42 (47%), Gaps = 1/42 (2%)
Query: 1311 AIQSE-RVLENACGTDNGGCSHLCLRSPLGYTCACPTGMPFE 1351
A+ S+ R C +NGGC C + G C+CP G +
Sbjct: 233 ALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQ 274
Score = 33.5 bits (73), Expect = 7.0
Identities = 14/39 (35%), Positives = 21/39 (53%), Gaps = 1/39 (2%)
Query: 1017 LGCGKNNGGCSHLCLLKP-GGRSCACPIGIKLNKDGKTC 1054
+ C + GC+H+C P GG +C C G L ++ K C
Sbjct: 164 MNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDC 202
>Z82214-3|CAI21674.1| 988|Homo sapiens protein ( Human DNA sequence
from clone RP3-526I14 on chromosome 22. ).
Length = 988
Score = 79.8 bits (188), Expect = 8e-14
Identities = 73/261 (27%), Positives = 110/261 (42%), Gaps = 38/261 (14%)
Query: 269 ECKNTKCVPKDFQC---DG---DNDCGDWTDEDSCPMVPGSC-----NA-GEFKCNDGKC 316
EC N +P +++C DG +D + D D C G C NA G ++C +C
Sbjct: 90 ECIN---IPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYEC---QC 143
Query: 317 IPERWRCDNERDCADGGDE-LNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGE 375
+ DN+ C +E +NC N C+ + C R CD +
Sbjct: 144 HSGFFLSDNQHTCIHRSNEGMNCM-NKDHGCA---HIC--RETPKGGVACDCRPGFDLAQ 197
Query: 376 DEMNCEVSCEEDQYTCRPQ-EHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCS 434
++ +C ++C C+ E + C + + + C E C +
Sbjct: 198 NQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCI-----ETCAVNNG-- 250
Query: 435 AEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFR 494
C++ C T G C+CP+GF L D +C+DI+EC+ C C NTVGSF
Sbjct: 251 ---GCDRTCKDTATG-VRCSCPVGFTLQPDGKTCKDINECLVNNGG-CDHFCRNTVGSFE 305
Query: 495 CGCMTGYILRPDERSCKPTGE 515
CGC GY L DER+C+ E
Sbjct: 306 CGCRKGYKLLTDERTCQDIDE 326
Score = 69.3 bits (162), Expect = 1e-10
Identities = 56/200 (28%), Positives = 81/200 (40%), Gaps = 13/200 (6%)
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV 382
C + + D G C + D TC + C + CD T +C V
Sbjct: 213 CQHSCEDTDTGPTCGCHQKYALHS--DGRTCIET-CAVNNGGCDRTCKDTATGVRCSCPV 269
Query: 383 --SCEEDQYTCRP-QEHLMSNAFRNCVNRKHVCDGMKDCPRG----DDEERCPLKRKCSA 435
+ + D TC+ E L++N + R V C +G DE C +CS
Sbjct: 270 GFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSF 329
Query: 436 EEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRC 495
E C+ +CI + G C C G++L + C D+DEC C Q C NT GS+ C
Sbjct: 330 ERTCDHICINS-PGSFQCLCHRGYILYGTTH-CGDVDECSMSNGS-CDQGCVNTKGSYEC 386
Query: 496 GCMTGYILRPDERSCKPTGE 515
C G L + + C TG+
Sbjct: 387 VCPPGRRLHWNGKDCVETGK 406
Score = 64.1 bits (149), Expect = 4e-09
Identities = 27/72 (37%), Positives = 41/72 (56%), Gaps = 2/72 (2%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCM 498
C CI G+ C C GF+LA D ++C D+DEC + + C Q C N +GS+ C C
Sbjct: 87 CVHECINI-PGNYRCTCFDGFMLAHDGHNCLDVDECQ-DNNGGCQQICVNAMGSYECQCH 144
Query: 499 TGYILRPDERSC 510
+G+ L ++ +C
Sbjct: 145 SGFFLSDNQHTC 156
Score = 49.6 bits (113), Expect = 1e-04
Identities = 19/38 (50%), Positives = 21/38 (55%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NNGGC C G C+CP+G L DGKTC D
Sbjct: 245 CAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKD 282
Score = 44.8 bits (101), Expect = 0.003
Identities = 23/64 (35%), Positives = 31/64 (48%), Gaps = 3/64 (4%)
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQ-DPVCSQTCSNTVGSFRCGCMTGYILRPDERSCK 511
C C G+ E K C DIDEC + + C C N G++RC C G++L D +C
Sbjct: 59 CLCKPGYK-GEGK-QCEDIDECENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCL 116
Query: 512 PTGE 515
E
Sbjct: 117 DVDE 120
Score = 42.7 bits (96), Expect = 0.012
Identities = 18/38 (47%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NNGGC H C G C C G KL D +TC D
Sbjct: 286 CLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQD 323
Score = 41.5 bits (93), Expect = 0.027
Identities = 17/41 (41%), Positives = 21/41 (51%)
Query: 1016 TLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
TL C NGGC H C G +C C L+ DG+TC +
Sbjct: 203 TLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIE 243
Score = 39.1 bits (87), Expect = 0.14
Identities = 16/34 (47%), Positives = 17/34 (50%)
Query: 1023 NGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
NGGC H C+ PG C C G L DG C D
Sbjct: 84 NGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLD 117
Score = 38.7 bits (86), Expect = 0.19
Identities = 14/38 (36%), Positives = 20/38 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C +NG C C+ G C CP G +L+ +GK C +
Sbjct: 366 CSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVE 403
Score = 36.7 bits (81), Expect = 0.76
Identities = 14/36 (38%), Positives = 18/36 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C NNGGC +C+ G C C G L+ + TC
Sbjct: 121 CQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTC 156
Score = 35.9 bits (79), Expect = 1.3
Identities = 14/42 (33%), Positives = 20/42 (47%), Gaps = 1/42 (2%)
Query: 1311 AIQSE-RVLENACGTDNGGCSHLCLRSPLGYTCACPTGMPFE 1351
A+ S+ R C +NGGC C + G C+CP G +
Sbjct: 233 ALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQ 274
Score = 33.5 bits (73), Expect = 7.0
Identities = 14/39 (35%), Positives = 21/39 (53%), Gaps = 1/39 (2%)
Query: 1017 LGCGKNNGGCSHLCLLKP-GGRSCACPIGIKLNKDGKTC 1054
+ C + GC+H+C P GG +C C G L ++ K C
Sbjct: 164 MNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDC 202
>Z97832-1|CAI20187.1| 993|Homo sapiens protein ( Human DNA sequence
from clone RP3-329A5 on chromosome 6p21.1-21.33. ).
Length = 993
Score = 79.4 bits (187), Expect = 1e-13
Identities = 86/293 (29%), Positives = 119/293 (40%), Gaps = 56/293 (19%)
Query: 266 IDFECKNT----KCVPKD-FQCDGDN--DCGDWTDEDSCPMVPGSCNA-GEFKCN--DGK 315
ID C+NT KC+ K + DG + D + ED+ V N G ++C DG
Sbjct: 42 IDAICQNTPRSYKCICKSGYTGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGF 101
Query: 316 CIP-ERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNG 374
+ + C + +CA+G C+ + + + Y C C +L D C
Sbjct: 102 HLAHDGHNCLDVDECAEGNG--GCQQSCVN--MMGSYEC---HCREGFFLSDNQHTCIQR 154
Query: 375 EDE-MNCEVS-------CEEDQY-----TCRPQEHLMSNAFRNCV--------NRKHVCD 413
+E MNC C E CRP L N R+C +H CD
Sbjct: 155 PEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQ-RDCKLTCNYGNGGCQHTCD 213
Query: 414 GMKDCPRGDDEERCPLKRKCSAEEK-CEKLCITTYDG-----HAA-----CACPMGFLLA 462
+ PR C +K + K C + C G H A C CP+GF+L
Sbjct: 214 DTEQGPRCG----CHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQ 269
Query: 463 EDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
D+ +C+DIDEC C C NTVGSF C C GY L +ER+C+ E
Sbjct: 270 PDRKTCKDIDECRLNNGG-CDHICRNTVGSFECSCKKGYKLLINERNCQDIDE 321
Score = 61.7 bits (143), Expect = 2e-08
Identities = 33/91 (36%), Positives = 46/91 (50%), Gaps = 8/91 (8%)
Query: 418 CPRG----DDEERCPLKRKCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDID 472
CP G D + C +C C+ +C T G C+C G+ L ++ +C+DID
Sbjct: 262 CPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTV-GSFECSCKKGYKLLINERNCQDID 320
Query: 473 ECMYEQDPVCSQTCSNTVGSFRCGCMTGYIL 503
EC + D C C NT GSF+C C GY+L
Sbjct: 321 ECSF--DRTCDHICVNTPGSFQCLCHRGYLL 349
Score = 60.5 bits (140), Expect = 5e-08
Identities = 50/186 (26%), Positives = 76/186 (40%), Gaps = 15/186 (8%)
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDG-VRDCTNGEDEMNCE 381
C + D + G C + + D TC + C + CD D G C
Sbjct: 208 CQHTCDDTEQGPRCGCHIKFVLHT--DGKTCIET-CAVNNGGCDSKCHDAATGV-HCTCP 263
Query: 382 VS--CEEDQYTCRP-QEHLMSNAFRNCVNRKHVCDGMKDCPRGD----DEERCPLKRKCS 434
V + D+ TC+ E ++N + + R V C +G +E C +CS
Sbjct: 264 VGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECS 323
Query: 435 AEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFR 494
+ C+ +C+ T G C C G+LL + C D+DEC + C C NT GS++
Sbjct: 324 FDRTCDHICVNT-PGSFQCLCHRGYLLYGITH-CGDVDECSINRGG-CRFGCINTPGSYQ 380
Query: 495 CGCMTG 500
C C G
Sbjct: 381 CTCPAG 386
Score = 44.8 bits (101), Expect = 0.003
Identities = 18/38 (47%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NNGGC C G C CP+G L D KTC D
Sbjct: 240 CAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKD 277
Score = 42.3 bits (95), Expect = 0.015
Identities = 18/40 (45%), Positives = 20/40 (50%)
Query: 1017 LGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
L C NGGC H C G C C I L+ DGKTC +
Sbjct: 199 LTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIE 238
Score = 40.3 bits (90), Expect = 0.061
Identities = 16/38 (42%), Positives = 20/38 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NNGGC H+C G C+C G KL + + C D
Sbjct: 281 CRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQD 318
Score = 39.1 bits (87), Expect = 0.14
Identities = 16/39 (41%), Positives = 21/39 (53%), Gaps = 1/39 (2%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGI-KLNKDGKTCAD 1056
C N GGC C+ PG C CP G +L+ +GK C +
Sbjct: 361 CSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTE 399
Score = 37.9 bits (84), Expect = 0.33
Identities = 15/39 (38%), Positives = 22/39 (56%), Gaps = 1/39 (2%)
Query: 1017 LGCGKNNGGCSHLCLLKP-GGRSCACPIGIKLNKDGKTC 1054
+ C N GC+H+C P GG +C C G +L K+ + C
Sbjct: 159 MNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDC 197
Score = 37.1 bits (82), Expect = 0.57
Identities = 15/36 (41%), Positives = 18/36 (50%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
++N GC H C+ PG C C G L DG C D
Sbjct: 77 EDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLD 112
Score = 36.7 bits (81), Expect = 0.76
Identities = 17/47 (36%), Positives = 22/47 (46%), Gaps = 2/47 (4%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTGM-PFEKSTTDQT-PKKCKSHP 1366
C + GGC C+ +P Y C CP G + D T P KC+ P
Sbjct: 361 CSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSP 407
Score = 35.1 bits (77), Expect = 2.3
Identities = 14/40 (35%), Positives = 18/40 (45%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGP 1058
C + NGGC C+ G C C G L+ + TC P
Sbjct: 116 CAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRP 155
>AY639608-1|AAU08347.1| 993|Homo sapiens signal peptide, CUB and
EGF-like domain containing protein 3 protein.
Length = 993
Score = 79.4 bits (187), Expect = 1e-13
Identities = 86/293 (29%), Positives = 119/293 (40%), Gaps = 56/293 (19%)
Query: 266 IDFECKNT----KCVPKD-FQCDGDN--DCGDWTDEDSCPMVPGSCNA-GEFKCN--DGK 315
ID C+NT KC+ K + DG + D + ED+ V N G ++C DG
Sbjct: 42 IDAICQNTPRSYKCICKSGYTGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGF 101
Query: 316 CIP-ERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNG 374
+ + C + +CA+G C+ + + + Y C C +L D C
Sbjct: 102 HLAHDGHNCLDVDECAEGNG--GCQQSCVN--MMGSYEC---HCREGFFLSDNQHTCIQR 154
Query: 375 EDE-MNCEVS-------CEEDQY-----TCRPQEHLMSNAFRNCV--------NRKHVCD 413
+E MNC C E CRP L N R+C +H CD
Sbjct: 155 PEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQ-RDCKLTCNYGNGGCQHTCD 213
Query: 414 GMKDCPRGDDEERCPLKRKCSAEEK-CEKLCITTYDG-----HAA-----CACPMGFLLA 462
+ PR C +K + K C + C G H A C CP+GF+L
Sbjct: 214 DTEQGPRCG----CHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQ 269
Query: 463 EDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
D+ +C+DIDEC C C NTVGSF C C GY L +ER+C+ E
Sbjct: 270 PDRKTCKDIDECRLNNGG-CDHICRNTVGSFECSCKKGYKLLINERNCQDIDE 321
Score = 61.7 bits (143), Expect = 2e-08
Identities = 33/91 (36%), Positives = 46/91 (50%), Gaps = 8/91 (8%)
Query: 418 CPRG----DDEERCPLKRKCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDID 472
CP G D + C +C C+ +C T G C+C G+ L ++ +C+DID
Sbjct: 262 CPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTV-GSFECSCKKGYKLLINERNCQDID 320
Query: 473 ECMYEQDPVCSQTCSNTVGSFRCGCMTGYIL 503
EC + D C C NT GSF+C C GY+L
Sbjct: 321 ECSF--DRTCDHICVNTPGSFQCLCHRGYLL 349
Score = 60.5 bits (140), Expect = 5e-08
Identities = 50/186 (26%), Positives = 76/186 (40%), Gaps = 15/186 (8%)
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDG-VRDCTNGEDEMNCE 381
C + D + G C + + D TC + C + CD D G C
Sbjct: 208 CQHTCDDTEQGPRCGCHIKFVLHT--DGKTCIET-CAVNNGGCDSKCHDAATGV-HCTCP 263
Query: 382 VS--CEEDQYTCRP-QEHLMSNAFRNCVNRKHVCDGMKDCPRGD----DEERCPLKRKCS 434
V + D+ TC+ E ++N + + R V C +G +E C +CS
Sbjct: 264 VGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECS 323
Query: 435 AEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFR 494
+ C+ +C+ T G C C G+LL + C D+DEC + C C NT GS++
Sbjct: 324 FDRTCDHICVNT-PGSFQCLCHRGYLLYGITH-CGDVDECSINRGG-CRFGCINTPGSYQ 380
Query: 495 CGCMTG 500
C C G
Sbjct: 381 CTCPAG 386
Score = 44.8 bits (101), Expect = 0.003
Identities = 18/38 (47%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NNGGC C G C CP+G L D KTC D
Sbjct: 240 CAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKD 277
Score = 42.3 bits (95), Expect = 0.015
Identities = 18/40 (45%), Positives = 20/40 (50%)
Query: 1017 LGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
L C NGGC H C G C C I L+ DGKTC +
Sbjct: 199 LTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIE 238
Score = 40.3 bits (90), Expect = 0.061
Identities = 16/38 (42%), Positives = 20/38 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NNGGC H+C G C+C G KL + + C D
Sbjct: 281 CRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQD 318
Score = 39.1 bits (87), Expect = 0.14
Identities = 16/39 (41%), Positives = 21/39 (53%), Gaps = 1/39 (2%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGI-KLNKDGKTCAD 1056
C N GGC C+ PG C CP G +L+ +GK C +
Sbjct: 361 CSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTE 399
Score = 37.9 bits (84), Expect = 0.33
Identities = 15/39 (38%), Positives = 22/39 (56%), Gaps = 1/39 (2%)
Query: 1017 LGCGKNNGGCSHLCLLKP-GGRSCACPIGIKLNKDGKTC 1054
+ C N GC+H+C P GG +C C G +L K+ + C
Sbjct: 159 MNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDC 197
Score = 37.1 bits (82), Expect = 0.57
Identities = 15/36 (41%), Positives = 18/36 (50%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
++N GC H C+ PG C C G L DG C D
Sbjct: 77 EDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLD 112
Score = 36.7 bits (81), Expect = 0.76
Identities = 17/47 (36%), Positives = 22/47 (46%), Gaps = 2/47 (4%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTGM-PFEKSTTDQT-PKKCKSHP 1366
C + GGC C+ +P Y C CP G + D T P KC+ P
Sbjct: 361 CSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSP 407
Score = 35.1 bits (77), Expect = 2.3
Identities = 14/40 (35%), Positives = 18/40 (45%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGP 1058
C + NGGC C+ G C C G L+ + TC P
Sbjct: 116 CAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRP 155
>AK126750-1|BAC86671.1| 644|Homo sapiens protein ( Homo sapiens
cDNA FLJ44797 fis, clone BRACE3040644, highly similar
to Homo sapiens low density lipoprotein receptor-related
protein 3 (LRP3). ).
Length = 644
Score = 79.4 bits (187), Expect = 1e-13
Identities = 37/108 (34%), Positives = 50/108 (46%), Gaps = 11/108 (10%)
Query: 275 CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK--CIPERWRCDNERDCADG 332
C + +CDG C DE CP +C ++ C G C RC+N++ C DG
Sbjct: 265 CFSEPQRCDGWWHCASGRDEQGCP----ACPPDQYPCEGGGGLCYTPADRCNNQKSCPDG 320
Query: 333 GDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNC 380
DE NC +C + C C+ +TW CDG DC +G DE C
Sbjct: 321 ADEKNCF-----SCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 363
Score = 73.7 bits (173), Expect = 5e-12
Identities = 35/92 (38%), Positives = 52/92 (56%), Gaps = 12/92 (13%)
Query: 303 SCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCK------PNSIRNCSLDEYTCA-- 354
SC A EF+C++GKC+P W+C+ +C DG DE NC P S+ C + C+
Sbjct: 39 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSL--CPGGTFPCSGA 96
Query: 355 -DRRCVLKTWLCDGVRDCTNGEDEMNC-EVSC 384
RC+ CDG++DC +G DE C +++C
Sbjct: 97 RSTRCLPVERRCDGLQDCGDGSDEAGCPDLAC 128
Score = 73.3 bits (172), Expect = 7e-12
Identities = 34/84 (40%), Positives = 46/84 (54%), Gaps = 8/84 (9%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPM----VPGS-CNAGEFKCNDG--- 314
C +F C N KC+P +QC+ ++CGD +DE +C PGS C G F C+
Sbjct: 40 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARST 99
Query: 315 KCIPERWRCDNERDCADGGDELNC 338
+C+P RCD +DC DG DE C
Sbjct: 100 RCLPVERRCDGLQDCGDGSDEAGC 123
Score = 62.9 bits (146), Expect = 1e-08
Identities = 28/86 (32%), Positives = 43/86 (50%), Gaps = 2/86 (2%)
Query: 345 NCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRN 404
+C DE+ C + +C+ W C+ V +C +G DE NC E + P + R+
Sbjct: 39 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARS 98
Query: 405 --CVNRKHVCDGMKDCPRGDDEERCP 428
C+ + CDG++DC G DE CP
Sbjct: 99 TRCLPVERRCDGLQDCGDGSDEAGCP 124
Score = 58.8 bits (136), Expect = 2e-07
Identities = 38/117 (32%), Positives = 47/117 (40%), Gaps = 17/117 (14%)
Query: 313 DGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTC--ADRRCVLKTWLCDGVRD 370
D C E RCD CA G DE C C D+Y C C C+ +
Sbjct: 262 DQGCFSEPQRCDGWWHCASGRDEQGCPA-----CPPDQYPCEGGGGLCYTPADRCNNQKS 316
Query: 371 CTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERC 427
C +G DE NC SC+ + C +N C+ CDG +DC G DE C
Sbjct: 317 CPDGADEKNC-FSCQPGTFHCG------TNL---CIFETWRCDGQEDCQDGSDEHGC 363
Score = 47.6 bits (108), Expect = 4e-04
Identities = 26/79 (32%), Positives = 33/79 (41%), Gaps = 8/79 (10%)
Query: 349 DEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNR 408
D + D+ C + CDG C +G DE C +C DQY C L C
Sbjct: 256 DGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCP-ACPPDQYPCEGGGGL-------CYTP 307
Query: 409 KHVCDGMKDCPRGDDEERC 427
C+ K CP G DE+ C
Sbjct: 308 ADRCNNQKSCPDGADEKNC 326
Score = 42.3 bits (95), Expect = 0.015
Identities = 16/39 (41%), Positives = 24/39 (61%)
Query: 271 KNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEF 309
++T+C+P + +CDG DCGD +DE CP + G F
Sbjct: 97 RSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSF 135
Score = 40.3 bits (90), Expect = 0.061
Identities = 23/71 (32%), Positives = 34/71 (47%), Gaps = 4/71 (5%)
Query: 156 RSCDEHENRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGD 215
++C + T TN+CI W CDG DC D SDE C ++ +A IG
Sbjct: 324 KNCFSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLAAVPRKVITAA----LIGS 379
Query: 216 VITNPTVLIAL 226
++ ++IAL
Sbjct: 380 LVCGLLLVIAL 390
Score = 36.7 bits (81), Expect = 0.76
Identities = 13/35 (37%), Positives = 18/35 (51%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSC 297
C F C C+ + ++CDG DC D +DE C
Sbjct: 329 CQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 363
Score = 34.3 bits (75), Expect = 4.0
Identities = 13/23 (56%), Positives = 15/23 (65%)
Query: 173 CIALEWLCDGDNDCGDFSDEINC 195
C+ +E CDG DCGD SDE C
Sbjct: 101 CLPVERRCDGLQDCGDGSDEAGC 123
>AF452494-1|AAN76808.1| 993|Homo sapiens CUB and EGF containing
protein protein.
Length = 993
Score = 79.4 bits (187), Expect = 1e-13
Identities = 86/293 (29%), Positives = 119/293 (40%), Gaps = 56/293 (19%)
Query: 266 IDFECKNT----KCVPKD-FQCDGDN--DCGDWTDEDSCPMVPGSCNA-GEFKCN--DGK 315
ID C+NT KC+ K + DG + D + ED+ V N G ++C DG
Sbjct: 42 IDAICQNTPRSYKCICKSGYTGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGF 101
Query: 316 CIP-ERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNG 374
+ + C + +CA+G C+ + + + Y C C +L D C
Sbjct: 102 HLAHDGHNCLDVDECAEGNG--GCQQSCVN--MMGSYEC---HCREGFFLSDNQHTCIQR 154
Query: 375 EDE-MNCEVS-------CEEDQY-----TCRPQEHLMSNAFRNCV--------NRKHVCD 413
+E MNC C E CRP L N R+C +H CD
Sbjct: 155 PEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQ-RDCKLTCNYGNGGCQHTCD 213
Query: 414 GMKDCPRGDDEERCPLKRKCSAEEK-CEKLCITTYDG-----HAA-----CACPMGFLLA 462
+ PR C +K + K C + C G H A C CP+GF+L
Sbjct: 214 DTEQGPRCG----CHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQ 269
Query: 463 EDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
D+ +C+DIDEC C C NTVGSF C C GY L +ER+C+ E
Sbjct: 270 PDRKTCKDIDECRLNNGG-CDHICRNTVGSFECSCKKGYKLLINERNCQDIDE 321
Score = 61.7 bits (143), Expect = 2e-08
Identities = 33/91 (36%), Positives = 46/91 (50%), Gaps = 8/91 (8%)
Query: 418 CPRG----DDEERCPLKRKCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDID 472
CP G D + C +C C+ +C T G C+C G+ L ++ +C+DID
Sbjct: 262 CPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTV-GSFECSCKKGYKLLINERNCQDID 320
Query: 473 ECMYEQDPVCSQTCSNTVGSFRCGCMTGYIL 503
EC + D C C NT GSF+C C GY+L
Sbjct: 321 ECSF--DRTCDHICVNTPGSFQCLCHRGYLL 349
Score = 60.5 bits (140), Expect = 5e-08
Identities = 50/186 (26%), Positives = 76/186 (40%), Gaps = 15/186 (8%)
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDG-VRDCTNGEDEMNCE 381
C + D + G C + + D TC + C + CD D G C
Sbjct: 208 CQHTCDDTEQGPRCGCHIKFVLHT--DGKTCIET-CAVNNGGCDSKCHDAATGV-HCTCP 263
Query: 382 VS--CEEDQYTCRP-QEHLMSNAFRNCVNRKHVCDGMKDCPRGD----DEERCPLKRKCS 434
V + D+ TC+ E ++N + + R V C +G +E C +CS
Sbjct: 264 VGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECS 323
Query: 435 AEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFR 494
+ C+ +C+ T G C C G+LL + C D+DEC + C C NT GS++
Sbjct: 324 FDRTCDHICVNT-PGSFQCLCHRGYLLYGITH-CGDVDECSINRGG-CRFGCINTPGSYQ 380
Query: 495 CGCMTG 500
C C G
Sbjct: 381 CTCPAG 386
Score = 44.8 bits (101), Expect = 0.003
Identities = 18/38 (47%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NNGGC C G C CP+G L D KTC D
Sbjct: 240 CAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKD 277
Score = 42.3 bits (95), Expect = 0.015
Identities = 18/40 (45%), Positives = 20/40 (50%)
Query: 1017 LGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
L C NGGC H C G C C I L+ DGKTC +
Sbjct: 199 LTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIE 238
Score = 40.3 bits (90), Expect = 0.061
Identities = 16/38 (42%), Positives = 20/38 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NNGGC H+C G C+C G KL + + C D
Sbjct: 281 CRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQD 318
Score = 39.1 bits (87), Expect = 0.14
Identities = 16/39 (41%), Positives = 21/39 (53%), Gaps = 1/39 (2%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGI-KLNKDGKTCAD 1056
C N GGC C+ PG C CP G +L+ +GK C +
Sbjct: 361 CSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTE 399
Score = 37.9 bits (84), Expect = 0.33
Identities = 15/39 (38%), Positives = 22/39 (56%), Gaps = 1/39 (2%)
Query: 1017 LGCGKNNGGCSHLCLLKP-GGRSCACPIGIKLNKDGKTC 1054
+ C N GC+H+C P GG +C C G +L K+ + C
Sbjct: 159 MNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDC 197
Score = 37.1 bits (82), Expect = 0.57
Identities = 15/36 (41%), Positives = 18/36 (50%)
Query: 1021 KNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
++N GC H C+ PG C C G L DG C D
Sbjct: 77 EDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLD 112
Score = 36.7 bits (81), Expect = 0.76
Identities = 17/47 (36%), Positives = 22/47 (46%), Gaps = 2/47 (4%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTGM-PFEKSTTDQT-PKKCKSHP 1366
C + GGC C+ +P Y C CP G + D T P KC+ P
Sbjct: 361 CSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSP 407
Score = 35.1 bits (77), Expect = 2.3
Identities = 14/40 (35%), Positives = 18/40 (45%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGP 1058
C + NGGC C+ G C C G L+ + TC P
Sbjct: 116 CAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRP 155
>AF093118-1|AAC62107.1| 448|Homo sapiens UP50 protein.
Length = 448
Score = 79.0 bits (186), Expect = 1e-13
Identities = 35/94 (37%), Positives = 48/94 (51%), Gaps = 2/94 (2%)
Query: 422 DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV 481
+D C +C+ E C + C+ TY G C C G+ L ED C D+DEC + + +
Sbjct: 200 EDGRSCQDVNECATENPCVQTCVNTY-GSFICRCDPGYELEEDGVHCSDMDECSFSEF-L 257
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C C N G++ C C GYIL D RSC+ E
Sbjct: 258 CQHECVNQPGTYFCSCPPGYILLDDNRSCQDINE 291
Score = 64.9 bits (151), Expect = 2e-09
Identities = 64/235 (27%), Positives = 95/235 (40%), Gaps = 36/235 (15%)
Query: 311 CNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDG--- 367
C G + E +C + +CA D C P I YTC+ C WL +G
Sbjct: 113 CRFGYQMDESNQCVDVDECAT--DSHQCNPTQICINMKGGYTCS---CTDGYWLLEGQCL 167
Query: 368 -VRDCTNGEDEMNC-----EVSC--------EEDQYTCRPQEHLMSN--AFRNCVNR--K 409
+ +C G + C SC ED +C+ + + CVN
Sbjct: 168 DIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGS 227
Query: 410 HVCDGMKDCPRGDDEERCPLKRKCSAEE-KCEKLCITTYDGHAACACPMGFLLAEDKYSC 468
+C +D C +CS E C+ C+ G C+CP G++L +D SC
Sbjct: 228 FICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQ-PGTYFCSCPPGYILLDDNRSC 286
Query: 469 RDIDECMYEQDPVCS--QTCSNTVGSFRC----GCMTGYILRPDERSCKPTGESP 517
+DI+EC + ++ C+ QTC N G F+C C Y LR + C E+P
Sbjct: 287 QDINECEH-RNHTCNLQQTCYNLQGGFKCIDPIRCEEPY-LRISDNRCMCPAENP 339
Score = 64.9 bits (151), Expect = 2e-09
Identities = 35/100 (35%), Positives = 51/100 (51%), Gaps = 9/100 (9%)
Query: 422 DDEERCPLKRKCSAEE-KCE--KLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQ 478
D+ +C +C+ + +C ++CI G+ C+C G+ L E + C DIDEC Y
Sbjct: 120 DESNQCVDVDECATDSHQCNPTQICINMKGGYT-CSCTDGYWLLEGQ--CLDIDECRYGY 176
Query: 479 DPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPT 518
C Q C+N GS+ C C G+ L D RSC+ E T
Sbjct: 177 ---CQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECAT 213
Score = 41.1 bits (92), Expect = 0.035
Identities = 16/33 (48%), Positives = 19/33 (57%)
Query: 1024 GGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
G C LC PG SC C G LN+DG++C D
Sbjct: 175 GYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQD 207
Score = 35.1 bits (77), Expect = 2.3
Identities = 13/31 (41%), Positives = 18/31 (58%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C H C+ +PG C+CP G L D ++C D
Sbjct: 258 CQHECVNQPGTYFCSCPPGYILLDDNRSCQD 288
>X63556-1|CAA45118.1| 3002|Homo sapiens fibrillin protein.
Length = 3002
Score = 78.2 bits (184), Expect = 3e-13
Identities = 73/269 (27%), Positives = 107/269 (39%), Gaps = 25/269 (9%)
Query: 259 ELMRCAEIDFECKNTKC--VPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKC 316
++ C I C + KC F+C D+ ++E +C + C C G+C
Sbjct: 1159 DINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDID-ECRISPDLCGRGQC 1217
Query: 317 I--PERWRCDNERDCADGGDEL-NCKPNSIRNCSLDEYTCADRRC--VLKTWLCDGVRDC 371
+ P + C + G + NC I C D C C ++ C+ C
Sbjct: 1218 VNTPGDFECKCDEGYESGFMMMKNCM--DIDECQRDPLLCRGGVCHNTEGSYRCE----C 1271
Query: 372 TNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNR--KHVCDGMKDCPRGDDEERCPL 429
G +++ +S D C HL N CVN K+ C D C
Sbjct: 1272 PPGH-QLSPNISACIDINECELSAHLCPNG--RCVNLIGKYQCACNPGYHSTPDRLFCVD 1328
Query: 430 KRKCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VC-SQTC 486
+CS CE C T +G C+C GF L D+ SC DIDEC E +P +C C
Sbjct: 1329 IDECSIMNGGCETFC-TNSEGSYECSCQPGFALMPDQRSCTDIDEC--EDNPNICDGGQC 1385
Query: 487 SNTVGSFRCGCMTGYILRPDERSCKPTGE 515
+N G +RC C G++ D ++C E
Sbjct: 1386 TNIPGEYRCLCYDGFMASEDMKTCVDVNE 1414
Score = 74.9 bits (176), Expect = 2e-12
Identities = 73/265 (27%), Positives = 99/265 (37%), Gaps = 24/265 (9%)
Query: 259 ELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIP 318
+L+ C +ID EC+N ++ +C N G + C PG +CND
Sbjct: 1933 KLLVCEDID-ECQNGPVCQRNAECI--NTAGSYR----CDCKPGYRFTSTGQCNDRNECQ 1985
Query: 319 ERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDE 377
E + C D C ++ + D+ C D C C G C N
Sbjct: 1986 EIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDINECERDA--C-GNGTCRNTIGS 2042
Query: 378 MNCEVS---CEEDQYTCRPQEHLMS---NAFRN--CVNR--KHVCDGMKDCPRGDDEERC 427
NC + C + S N RN C+N C + D C
Sbjct: 2043 FNCRCNHGFILSHNNDCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTC 2102
Query: 428 PLKRKCSAE-EKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTC 486
+C E KC DG C CP G+ L +K C DIDEC+ E + TC
Sbjct: 2103 VDINECLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNEK--CEDIDECVEEPEICALGTC 2160
Query: 487 SNTVGSFRCGCMTGYILRPDERSCK 511
SNT GSF+C C G+ L R C+
Sbjct: 2161 SNTEGSFKCLCPEGFSLSSSGRRCQ 2185
Score = 73.3 bits (172), Expect = 7e-12
Identities = 63/220 (28%), Positives = 90/220 (40%), Gaps = 27/220 (12%)
Query: 304 CNAGEFKCNDGKCIPE--RWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLK 361
C + C +G+CIP +RC+ + G +L+ + I ++ CA C+
Sbjct: 584 CQLVRYLCQNGRCIPTPGSYRCECNK-----GFQLDLRGECIDVDECEKNPCAGGECINN 638
Query: 362 --TWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRK---H-VCDGM 415
++ C C G C D C + +N C+N H VC+
Sbjct: 639 QGSYTCQ----CRAGYQSTLTRTECR-DIDECLQNGRICNNG--RCINTDGSFHCVCNAG 691
Query: 416 KDCPRGDDEERCPLKRKCSAEEKC-EKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
R D + C +CS C +CI DG C C GF LA D C+DI+EC
Sbjct: 692 FHVTR--DGKNCEDMDECSIRNMCLNGMCINE-DGSFKCICKPGFQLASDGRYCKDINEC 748
Query: 475 MYEQDPVC-SQTCSNTVGSFRCGCMTGYILRPDERSCKPT 513
E +C + C NT GS+RC C G + D R C T
Sbjct: 749 --ETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDT 786
Score = 67.7 bits (158), Expect = 4e-10
Identities = 75/278 (26%), Positives = 96/278 (34%), Gaps = 39/278 (14%)
Query: 276 VPKDFQCDGDNDCGD---WTDEDSCPMVPGS----CNAGEFKCNDGKCIPERWRCD-NER 327
+P C ++C D D C +PG C G D K + CD N
Sbjct: 1361 MPDQRSCTDIDECEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPN 1420
Query: 328 DCADGGDELNCKPNSIRNCSLD------EYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNC 380
C G E N K + I +C + + C D C + C CTN C
Sbjct: 1421 ICLSGTCE-NTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKC 1479
Query: 381 EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKR-------KC 433
SC + + C N H+C DC RC K C
Sbjct: 1480 --SCSPGWIG----DGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGFTC 1533
Query: 434 SAEEKCEK---LC----ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTC 486
+ ++C + LC G C C MGF+ + D +C DIDEC V TC
Sbjct: 1534 TDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVFG-TC 1592
Query: 487 SNTVGSFRCGCMTGYILRPDERSCKPTGE--SPTLLFS 522
N G FRC C GY L +C E PT S
Sbjct: 1593 HNLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCIS 1630
Score = 65.7 bits (153), Expect = 1e-09
Identities = 32/83 (38%), Positives = 43/83 (51%), Gaps = 5/83 (6%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQT---CSNTVGSFRC 495
C C+ TY G C CP+G++L ED+ C+D DEC E C++ C N +G++ C
Sbjct: 2348 CAFRCVNTY-GSYECKCPVGYVLREDRRMCKDEDECE-EGKHDCTEKQMECKNLIGTYMC 2405
Query: 496 GCMTGYILRPDERSCKPTGESPT 518
C GY RPD C E T
Sbjct: 2406 ICGPGYQRRPDGEGCVDENECQT 2428
Score = 65.7 bits (153), Expect = 1e-09
Identities = 30/76 (39%), Positives = 43/76 (56%), Gaps = 3/76 (3%)
Query: 427 CPLKRKCS-AEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQT 485
C +C+ A + C +C T +G C+CP G++L ED SC+D+DEC +Q C
Sbjct: 2573 CVDLNECNQAPKPCNFICKNT-EGSYQCSCPKGYILQEDGRSCKDLDECATKQHN-CQFL 2630
Query: 486 CSNTVGSFRCGCMTGY 501
C NT+G F C C G+
Sbjct: 2631 CVNTIGGFTCKCPPGF 2646
Score = 64.5 bits (150), Expect = 3e-09
Identities = 66/231 (28%), Positives = 88/231 (38%), Gaps = 28/231 (12%)
Query: 293 DEDSCPMVPGSCN-------AGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRN 345
D D C +PG C G F+C +C + D C D DE P RN
Sbjct: 1897 DIDECREIPGVCENGVCINMVGSFRC---ECPVGFFYNDKLLVCEDI-DECQNGPVCQRN 1952
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNC 405
T RC K G R + G+ N C+E C + + + C
Sbjct: 1953 AECIN-TAGSYRCDCKP----GYRFTSTGQ--CNDRNECQEIPNICSHGQCIDTVGSFYC 2005
Query: 406 VNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDK 465
+ G K DD+ C +C + C T G C C GF+L+ +
Sbjct: 2006 LCHT----GFKT---NDDQTMCLDINECERDACGNGTCRNTI-GSFNCRCNHGFILSHNN 2057
Query: 466 YSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C D+DEC +C C NTVGSF+C C GY + PD R+C E
Sbjct: 2058 -DCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINE 2107
Score = 64.5 bits (150), Expect = 3e-09
Identities = 53/203 (26%), Positives = 79/203 (38%), Gaps = 19/203 (9%)
Query: 311 CND-GKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRR-CVLKTWLCDGV 368
C D +C ++ C GG C P ++ + +C D C LC
Sbjct: 2614 CKDLDECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHT----SCIDNNECTSDINLCGSK 2669
Query: 369 RDCTNGEDEMNCEV----SCEEDQYTCRPQEHLMSNAFRNCVNR-KHVCDGMK-DCPRGD 422
C N CE S ++ +C + N C + +++ G + CP+G
Sbjct: 2670 GICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGN--HRCQHGCQNIIGGYRCSCPQGY 2727
Query: 423 DEE----RCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQ 478
+ +C + +C + C G C CP GF + C+DI+EC Q
Sbjct: 2728 LQHYQWNQCVDENECLSAHICGGASCHNTLGSYKCMCPAGFQYEQFSGGCQDINECGSAQ 2787
Query: 479 DPVCSQTCSNTVGSFRCGCMTGY 501
P CS CSNT G + CGC GY
Sbjct: 2788 AP-CSYGCSNTEGGYLCGCPPGY 2809
Score = 63.7 bits (148), Expect = 6e-09
Identities = 71/269 (26%), Positives = 101/269 (37%), Gaps = 47/269 (17%)
Query: 270 CKNTKCV--PKDFQCDGDN--DCG-----DWTDEDSCPMVPGSCNAGEFKCNDG----KC 316
C +CV P DF+C D + G + D D C P C G +G +C
Sbjct: 1212 CGRGQCVNTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCEC 1271
Query: 317 IPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCV--LKTWLCDGVRDCTNG 374
P N C D I C L + C + RCV + + C +
Sbjct: 1272 PPGHQLSPNISACID-----------INECELSAHLCPNGRCVNLIGKYQCACNPGYHST 1320
Query: 375 EDEMNCEVSCEEDQYTCRPQEHLMSNAFRN-CVNRKHVCDGMKDCPRGDDEERCPLKRKC 433
D + C V +E C +M+ C N +G +C P +R C
Sbjct: 1321 PDRLFC-VDIDE----CS----IMNGGCETFCTNS----EGSYECSCQPGFALMPDQRSC 1367
Query: 434 SAEEKCE---KLC----ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTC 486
+ ++CE +C T G C C GF+ +ED +C D++EC + S TC
Sbjct: 1368 TDIDECEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTC 1427
Query: 487 SNTVGSFRCGCMTGYILRPDERSCKPTGE 515
NT GSF C C GY + + C E
Sbjct: 1428 ENTKGSFICHCDMGYSGKKGKTGCTDINE 1456
Score = 63.7 bits (148), Expect = 6e-09
Identities = 69/264 (26%), Positives = 98/264 (37%), Gaps = 25/264 (9%)
Query: 263 CAEIDFECKNTK--CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNA--GEFKCNDGKCIP 318
C + D EC+ K C K +C N G + C PG GE ++ +C
Sbjct: 2376 CKDED-ECEEGKHDCTEKQMECK--NLIGTYM----CICGPGYQRRPDGEGCVDENECQT 2428
Query: 319 ERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRR---CVLKTWLCDGVRDCTNGE 375
+ C+N R C + C+ N S ++ C D R C + +N
Sbjct: 2429 KPGICENGR-CLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRN 2487
Query: 376 DEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCD-GMKDCPRGDDEERCPLKRKCS 434
E C+ + H F+ V K +C G G D + C +
Sbjct: 2488 PVTKSECCCDGGRGW---GPHCEICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVC 2544
Query: 435 AEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFR 494
+C G C C G+ SC D++EC P C+ C NT GS++
Sbjct: 2545 RNGEC-----VNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKP-CNFICKNTEGSYQ 2598
Query: 495 CGCMTGYILRPDERSCKPTGESPT 518
C C GYIL+ D RSCK E T
Sbjct: 2599 CSCPKGYILQEDGRSCKDLDECAT 2622
Score = 60.9 bits (141), Expect = 4e-08
Identities = 36/102 (35%), Positives = 45/102 (44%), Gaps = 6/102 (5%)
Query: 417 DCPRGDD--EERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
+CP G C +CS C G C C GF +C DI+EC
Sbjct: 2283 ECPFGYTLAGNECVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPGP-MMTCEDINEC 2341
Query: 475 MYEQDPV-CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
Q+P+ C+ C NT GS+ C C GY+LR D R CK E
Sbjct: 2342 A--QNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDE 2381
Score = 59.3 bits (137), Expect = 1e-07
Identities = 36/113 (31%), Positives = 51/113 (45%), Gaps = 4/113 (3%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
CI T DG C C GF + D +C D+DEC ++ + C N GSF+C C G+
Sbjct: 677 CINT-DGSFHCVCNAGFHVTRDGKNCEDMDECSI-RNMCLNGMCINEDGSFKCICKPGFQ 734
Query: 503 LRPDERSCKPTG--ESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYH 553
L D R CK E+P + + R + + + GL V +D H
Sbjct: 735 LASDGRYCKDINECETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTH 787
Score = 58.0 bits (134), Expect = 3e-07
Identities = 56/220 (25%), Positives = 80/220 (36%), Gaps = 19/220 (8%)
Query: 307 GEFKCND-GKCIPERWRCDNERDCAD--GGDELNCKPNSIRNCSLDEYTCADR-RCVLKT 362
G+ C D +C C C + G + +C P I D C D C T
Sbjct: 1447 GKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIG----DGIKCTDLDECSNGT 1502
Query: 363 WLCDGVRDCTN--GEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRK--HVCDGMK-D 417
+C DC N G C+ D +TC + N C N + + G + +
Sbjct: 1503 HMCSQHADCKNTMGSYRCLCKEGYTGDGFTCTDLDECSEN-LNLCGNGQCLNAPGGYRCE 1561
Query: 418 CPRG----DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDE 473
C G D + C +CS C G C C +G+ L +C D++E
Sbjct: 1562 CDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNE 1621
Query: 474 CMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPT 513
C+ + S C NT GS+ C C + L P C T
Sbjct: 1622 CL-DPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDT 1660
Score = 57.6 bits (133), Expect = 4e-07
Identities = 59/268 (22%), Positives = 104/268 (38%), Gaps = 24/268 (8%)
Query: 258 VELMRCAEIDFECKNTKCVPKD--FQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK 315
V++ C+ ++ C+ T C + ++C D+ SC + C C+ G+
Sbjct: 1327 VDIDECSIMNGGCE-TFCTNSEGSYECSCQPGFALMPDQRSCTDID-ECEDNPNICDGGQ 1384
Query: 316 C--IPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRC--VLKTWLCDGVRDC 371
C IP +RC D C + C L+ C C +++C
Sbjct: 1385 CTNIPGEYRCLCYDGFMASEDMKTCV--DVNECDLNPNICLSGTCENTKGSFICHCDMGY 1442
Query: 372 TNGEDEMNC-EVS-CEEDQYTCRPQEHLMSNA--FRNCVNRKHVCDGMKDCPRGDDEERC 427
+ + + C +++ CE + C + A F+ + + DG+K C D +E
Sbjct: 1443 SGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIK-CT--DLDECS 1499
Query: 428 PLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCS 487
CS C+ G C C G+ D ++C D+DEC + + C
Sbjct: 1500 NGTHMCSQHADCKNTM-----GSYRCLCKEGY--TGDGFTCTDLDECSENLNLCGNGQCL 1552
Query: 488 NTVGSFRCGCMTGYILRPDERSCKPTGE 515
N G +RC C G++ D ++C+ E
Sbjct: 1553 NAPGGYRCECDMGFVPSADGKACEDIDE 1580
Score = 57.6 bits (133), Expect = 4e-07
Identities = 72/269 (26%), Positives = 98/269 (36%), Gaps = 27/269 (10%)
Query: 259 ELMRCAEIDFECKNTKCV--PKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKC 316
+L C+E C N +C+ P ++C+ D D +C + C+ C G C
Sbjct: 1535 DLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDID-ECSLPNI-CVFGTC 1592
Query: 317 --IPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLK--TWLCDGVRDCT 372
+P +RC+ E NC + C LD TC CV +++CD D
Sbjct: 1593 HNLPGLFRCECEIGYELDRSGGNC--TDVNEC-LDPTTCISGNCVNTPGSYICDCPPDFE 1649
Query: 373 NGEDEMNCEVSCEEDQYT-CRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKR 431
+ C + + Y RP+ N C N V C C L +
Sbjct: 1650 LNPTRVGCVDTRSGNCYLDIRPRG---DNGDTACSNEIGVGVSKASCC-------CSLGK 1699
Query: 432 KCSAEEKCEKL-CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNT 489
CE + T + C GF DIDEC E +C C NT
Sbjct: 1700 AWGTP--CEMCPAVNTSEYKILCPGGEGFRPNPITVILEDIDECQ-ELPGLCQGGKCINT 1756
Query: 490 VGSFRCGCMTGYILRPDERSCKPTGESPT 518
GSF+C C TGY L D R C E T
Sbjct: 1757 FGSFQCRCPTGYYLNEDTRVCDDVNECET 1785
Score = 57.2 bits (132), Expect = 5e-07
Identities = 46/175 (26%), Positives = 70/175 (40%), Gaps = 16/175 (9%)
Query: 352 TCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVS--CEEDQYTCRPQEHLMS---NAFRNC 405
+C D C C+ + T G + +C +ED +C+ + + N C
Sbjct: 2572 SCVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQFLC 2631
Query: 406 VNRKHVCDGMKDCPRGDDEER--CPLKRKCSAE-EKC--EKLCITTYDGHAACACPMGFL 460
VN + CP G + C +C+++ C + +C T G C C GF
Sbjct: 2632 VNT--IGGFTCKCPPGFTQHHTSCIDNNECTSDINLCGSKGICQNT-PGSFTCECQRGFS 2688
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
L + SC D+DEC E + C C N +G +RC C GY+ C E
Sbjct: 2689 LDQTGSSCEDVDEC--EGNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENE 2741
Score = 56.4 bits (130), Expect = 9e-07
Identities = 26/65 (40%), Positives = 32/65 (49%), Gaps = 2/65 (3%)
Query: 449 GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDER 508
G C CP GF+ D +C DIDEC E P + C N+ GSF C C + L P +
Sbjct: 917 GSFVCTCPKGFIYKPDLKTCEDIDEC--ESSPCINGVCKNSPGSFICECSSESTLDPTKT 974
Query: 509 SCKPT 513
C T
Sbjct: 975 ICIET 979
Score = 55.6 bits (128), Expect = 2e-06
Identities = 31/94 (32%), Positives = 46/94 (48%), Gaps = 9/94 (9%)
Query: 429 LKRKCSAEEKCEKL------CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC 482
L+ +C ++CEK CI G C C G+ + CRDIDEC+ + +C
Sbjct: 615 LRGECIDVDECEKNPCAGGECINN-QGSYTCQCRAGYQSTLTRTECRDIDECL-QNGRIC 672
Query: 483 SQ-TCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
+ C NT GSF C C G+ + D ++C+ E
Sbjct: 673 NNGRCINTDGSFHCVCNAGFHVTRDGKNCEDMDE 706
Score = 55.6 bits (128), Expect = 2e-06
Identities = 61/264 (23%), Positives = 97/264 (36%), Gaps = 25/264 (9%)
Query: 264 AEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDS-CPMVPGSCNAGEFKCNDGKCIPERWR 322
A+ID ECK V ++ +C D + P + G+ +CN P +
Sbjct: 2532 ADID-ECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPK-PCNFI 2589
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADR-RCVLKTWLCDGVRDCTNGEDEMNCE 381
C N +G + +C I D +C D C K C + T G C
Sbjct: 2590 CKN----TEGSYQCSCPKGYI--LQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCP 2643
Query: 382 VSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMK-----DCPRGDDEER----CPLKRK 432
+ +C S+ N K +C +C RG ++ C +
Sbjct: 2644 PGFTQHHTSCIDNNECTSDI--NLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDE 2701
Query: 433 CSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCS-QTCSNTVG 491
C +C+ C G+ C+CP G+L C D +EC+ +C +C NT+G
Sbjct: 2702 CEGNHRCQHGCQNIIGGYR-CSCPQGYLQHYQWNQCVDENECLSAH--ICGGASCHNTLG 2758
Query: 492 SFRCGCMTGYILRPDERSCKPTGE 515
S++C C G+ C+ E
Sbjct: 2759 SYKCMCPAGFQYEQFSGGCQDINE 2782
Score = 54.8 bits (126), Expect = 3e-06
Identities = 70/261 (26%), Positives = 106/261 (40%), Gaps = 33/261 (12%)
Query: 272 NTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDG-KCIPERWRCDNERDCA 330
N C+ D +C N G+ C GS +CN+G + P+ C + +C
Sbjct: 2056 NNDCIDVD-ECASGN--GNLCRNGQCINTVGSFQC---QCNEGYEVAPDGRTCVDINECL 2109
Query: 331 DGGDELNCKPNSIRNCSLDEYTC-ADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCE--ED 387
+ C P + +N Y C L+ C+ + +C E E+ +C E
Sbjct: 2110 L--EPRKCAPGTCQNLD-GSYRCICPPGYSLQNEKCEDIDECVE-EPEICALGTCSNTEG 2165
Query: 388 QYTCR-PQEHLMSNAFRNCVN-RKHVC-----DGMKDCPRGDDEER----CPLKRKCSAE 436
+ C P+ +S++ R C + R C G P+ + + C LK +
Sbjct: 2166 SFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGE-GWG 2224
Query: 437 EKCEKLCITTYDGHAACACPMGF-LLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFR 494
+ CE LC T D CP G ++ S D+DEC ++ VC C NT GS+R
Sbjct: 2225 DPCE-LCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDEC--KEPDVCKHGQCINTDGSYR 2281
Query: 495 CGCMTGYILRPDERSCKPTGE 515
C C GY L +E C T E
Sbjct: 2282 CECPFGYTLAGNE--CVDTDE 2300
Score = 53.6 bits (123), Expect = 6e-06
Identities = 27/68 (39%), Positives = 30/68 (44%), Gaps = 1/68 (1%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
CI T G C CP G L E C DIDEC C+NTV S+ C C G+
Sbjct: 393 CINTV-GSFECKCPAGHKLNEVSQKCEDIDECSTIPGICEGGECTNTVSSYFCKCPPGFY 451
Query: 503 LRPDERSC 510
PD C
Sbjct: 452 TSPDGTRC 459
Score = 53.2 bits (122), Expect = 8e-06
Identities = 30/95 (31%), Positives = 41/95 (43%), Gaps = 5/95 (5%)
Query: 421 GDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP 480
G D C L CE L G C C G+ + +C DI+EC+
Sbjct: 852 GSDINECALDPDICPNGICENL-----RGTYKCICNSGYEVDSTGKNCVDINECVLNSLL 906
Query: 481 VCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
+ C NT GSF C C G+I +PD ++C+ E
Sbjct: 907 CDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDE 941
Score = 48.0 bits (109), Expect = 3e-04
Identities = 45/179 (25%), Positives = 64/179 (35%), Gaps = 23/179 (12%)
Query: 351 YTCADRRCVLKTWLCDGVRDCTNGEDEM---NCEVSCEEDQYTCRPQEHLMSNAFRNCVN 407
YT A CV T C C NG + E +CEE P + C
Sbjct: 2288 YTLAGNECV-DTDECSVGNPCGNGTCKNVIGGFECTCEEG---FEPGPMMTCEDINECAQ 2343
Query: 408 RKHVCDGMKDCPRGDDEERCPL-------KRKCSAEEKCEK---------LCITTYDGHA 451
+C G E +CP+ +R C E++CE+ + G
Sbjct: 2344 NPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTY 2403
Query: 452 ACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSC 510
C C G+ D C D +EC + + C NT GS+ C C G+ P++ C
Sbjct: 2404 MCICGPGYQRRPDGEGCVDENECQTKPGICENGRCLNTRGSYTCECNDGFTASPNQDEC 2462
Score = 46.4 bits (105), Expect = 0.001
Identities = 22/65 (33%), Positives = 30/65 (46%)
Query: 455 CPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTG 514
C GF+ +C+D+DEC C NTVGSF C C G+ L + C+
Sbjct: 362 CRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKCEDID 421
Query: 515 ESPTL 519
E T+
Sbjct: 422 ECSTI 426
Score = 44.8 bits (101), Expect = 0.003
Identities = 27/83 (32%), Positives = 39/83 (46%), Gaps = 4/83 (4%)
Query: 437 EKCEKLCI-TTYDGHAACACPMGFLLAE---DKYSCRDIDECMYEQDPVCSQTCSNTVGS 492
E+CE+ + T + C GF E K +DI+EC C NT+GS
Sbjct: 1122 EECEECPMRNTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPSLCTHGKCRNTIGS 1181
Query: 493 FRCGCMTGYILRPDERSCKPTGE 515
F+C C +G+ L +ER+C E
Sbjct: 1182 FKCRCDSGFALDSEERNCTDIDE 1204
Score = 38.3 bits (85), Expect = 0.25
Identities = 18/43 (41%), Positives = 21/43 (48%)
Query: 468 CRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSC 510
C DIDEC + C NT GSF+C C +G L R C
Sbjct: 1039 CEDIDECEVFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRIC 1081
Score = 36.3 bits (80), Expect = 1.00
Identities = 18/48 (37%), Positives = 24/48 (50%), Gaps = 5/48 (10%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTG---MPFEKSTTDQTPKKCKSHP 1366
C NGGC C S Y C+C G MP ++S TD +C+ +P
Sbjct: 1332 CSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTD--IDECEDNP 1377
Score = 36.3 bits (80), Expect = 1.00
Identities = 14/38 (36%), Positives = 17/38 (44%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NGGC C G C+C G L D ++C D
Sbjct: 1332 CSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTD 1369
Score = 36.3 bits (80), Expect = 1.00
Identities = 16/39 (41%), Positives = 20/39 (51%), Gaps = 1/39 (2%)
Query: 1019 CGKNNGGCSH-LCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C +N C + CL PGG C C +G + DGK C D
Sbjct: 1539 CSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACED 1577
Score = 35.5 bits (78), Expect = 1.7
Identities = 13/38 (34%), Positives = 20/38 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C + C+ +C G C+CP G L +DG++C D
Sbjct: 2579 CNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSCKD 2616
Score = 33.9 bits (74), Expect = 5.3
Identities = 13/38 (34%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C +N C+ C+ G C CP+G L +D + C D
Sbjct: 2341 CAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKD 2378
Score = 33.5 bits (73), Expect = 7.0
Identities = 12/28 (42%), Positives = 15/28 (53%)
Query: 1320 NACGTDNGGCSHLCLRSPLGYTCACPTG 1347
N CG+ CS+ C + GY C CP G
Sbjct: 2781 NECGSAQAPCSYGCSNTEGGYLCGCPPG 2808
>X62008-1|CAB56534.1| 517|Homo sapiens fibrillin 15 protein.
Length = 517
Score = 78.2 bits (184), Expect = 3e-13
Identities = 73/269 (27%), Positives = 107/269 (39%), Gaps = 25/269 (9%)
Query: 259 ELMRCAEIDFECKNTKC--VPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKC 316
++ C I C + KC F+C D+ ++E +C + C C G+C
Sbjct: 232 DINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDID-ECRISPDLCGRGQC 290
Query: 317 I--PERWRCDNERDCADGGDEL-NCKPNSIRNCSLDEYTCADRRC--VLKTWLCDGVRDC 371
+ P + C + G + NC I C D C C ++ C+ C
Sbjct: 291 VNTPGDFECKCDEGYESGFMMMKNCM--DIDECQRDPLLCRGGVCHNTEGSYRCE----C 344
Query: 372 TNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNR--KHVCDGMKDCPRGDDEERCPL 429
G +++ +S D C HL N CVN K+ C D C
Sbjct: 345 PPGH-QLSPNISACIDINECELSAHLCPNG--RCVNLIGKYQCACNPGYHSTPDRLFCVD 401
Query: 430 KRKCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VC-SQTC 486
+CS CE C T +G C+C GF L D+ SC DIDEC E +P +C C
Sbjct: 402 IDECSIMNGGCETFC-TNSEGSYECSCQPGFALMPDQRSCTDIDEC--EDNPNICDGGQC 458
Query: 487 SNTVGSFRCGCMTGYILRPDERSCKPTGE 515
+N G +RC C G++ D ++C E
Sbjct: 459 TNIPGEYRCLCYDGFMASEDMKTCVDVNE 487
Score = 61.7 bits (143), Expect = 2e-08
Identities = 69/255 (27%), Positives = 97/255 (38%), Gaps = 47/255 (18%)
Query: 270 CKNTKCV--PKDFQCDGDN--DCG-----DWTDEDSCPMVPGSCNAGEFKCNDG----KC 316
C +CV P DF+C D + G + D D C P C G +G +C
Sbjct: 285 CGRGQCVNTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCEC 344
Query: 317 IPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCV--LKTWLCDGVRDCTNG 374
P N C D I C L + C + RCV + + C +
Sbjct: 345 PPGHQLSPNISACID-----------INECELSAHLCPNGRCVNLIGKYQCACNPGYHST 393
Query: 375 EDEMNCEVSCEEDQYTCRPQEHLMSNAFRN-CVNRKHVCDGMKDCPRGDDEERCPLKRKC 433
D + C V +E C +M+ C N +G +C P +R C
Sbjct: 394 PDRLFC-VDIDE----CS----IMNGGCETFCTNS----EGSYECSCQPGFALMPDQRSC 440
Query: 434 SAEEKCE---KLC----ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTC 486
+ ++CE +C T G C C GF+ +ED +C D++EC + S TC
Sbjct: 441 TDIDECEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTC 500
Query: 487 SNTVGSFRCGCMTGY 501
NT GSF C C GY
Sbjct: 501 ENTKGSFICHCDMGY 515
Score = 44.8 bits (101), Expect = 0.003
Identities = 27/83 (32%), Positives = 39/83 (46%), Gaps = 4/83 (4%)
Query: 437 EKCEKLCI-TTYDGHAACACPMGFLLAE---DKYSCRDIDECMYEQDPVCSQTCSNTVGS 492
E+CE+ + T + C GF E K +DI+EC C NT+GS
Sbjct: 195 EECEECPMRNTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPSLCTHGKCRNTIGS 254
Query: 493 FRCGCMTGYILRPDERSCKPTGE 515
F+C C +G+ L +ER+C E
Sbjct: 255 FKCRCDSGFALDSEERNCTDIDE 277
Score = 38.3 bits (85), Expect = 0.25
Identities = 18/43 (41%), Positives = 21/43 (48%)
Query: 468 CRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSC 510
C DIDEC + C NT GSF+C C +G L R C
Sbjct: 112 CEDIDECEVFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRIC 154
Score = 36.3 bits (80), Expect = 1.00
Identities = 18/48 (37%), Positives = 24/48 (50%), Gaps = 5/48 (10%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTG---MPFEKSTTDQTPKKCKSHP 1366
C NGGC C S Y C+C G MP ++S TD +C+ +P
Sbjct: 405 CSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTD--IDECEDNP 450
Score = 36.3 bits (80), Expect = 1.00
Identities = 14/38 (36%), Positives = 17/38 (44%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NGGC C G C+C G L D ++C D
Sbjct: 405 CSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTD 442
>L13923-1|AAB02036.1| 2871|Homo sapiens fibrillin protein.
Length = 2871
Score = 78.2 bits (184), Expect = 3e-13
Identities = 73/269 (27%), Positives = 107/269 (39%), Gaps = 25/269 (9%)
Query: 259 ELMRCAEIDFECKNTKC--VPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKC 316
++ C I C + KC F+C D+ ++E +C + C C G+C
Sbjct: 1028 DINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDID-ECRISPDLCGRGQC 1086
Query: 317 I--PERWRCDNERDCADGGDEL-NCKPNSIRNCSLDEYTCADRRC--VLKTWLCDGVRDC 371
+ P + C + G + NC I C D C C ++ C+ C
Sbjct: 1087 VNTPGDFECKCDEGYESGFMMMKNCM--DIDECQRDPLLCRGGVCHNTEGSYRCE----C 1140
Query: 372 TNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNR--KHVCDGMKDCPRGDDEERCPL 429
G +++ +S D C HL N CVN K+ C D C
Sbjct: 1141 PPGH-QLSPNISACIDINECELSAHLCPNG--RCVNLIGKYQCACNPGYHSTPDRLFCVD 1197
Query: 430 KRKCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VC-SQTC 486
+CS CE C T +G C+C GF L D+ SC DIDEC E +P +C C
Sbjct: 1198 IDECSIMNGGCETFC-TNSEGSYECSCQPGFALMPDQRSCTDIDEC--EDNPNICDGGQC 1254
Query: 487 SNTVGSFRCGCMTGYILRPDERSCKPTGE 515
+N G +RC C G++ D ++C E
Sbjct: 1255 TNIPGEYRCLCYDGFMASEDMKTCVDVNE 1283
Score = 74.9 bits (176), Expect = 2e-12
Identities = 73/265 (27%), Positives = 99/265 (37%), Gaps = 24/265 (9%)
Query: 259 ELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIP 318
+L+ C +ID EC+N ++ +C N G + C PG +CND
Sbjct: 1802 KLLVCEDID-ECQNGPVCQRNAECI--NTAGSYR----CDCKPGYRFTSTGQCNDRNECQ 1854
Query: 319 ERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDE 377
E + C D C ++ + D+ C D C C G C N
Sbjct: 1855 EIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDINECERDA--C-GNGTCRNTIGS 1911
Query: 378 MNCEVS---CEEDQYTCRPQEHLMS---NAFRN--CVNR--KHVCDGMKDCPRGDDEERC 427
NC + C + S N RN C+N C + D C
Sbjct: 1912 FNCRCNHGFILSHNNDCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTC 1971
Query: 428 PLKRKCSAE-EKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTC 486
+C E KC DG C CP G+ L +K C DIDEC+ E + TC
Sbjct: 1972 VDINECLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNEK--CEDIDECVEEPEICALGTC 2029
Query: 487 SNTVGSFRCGCMTGYILRPDERSCK 511
SNT GSF+C C G+ L R C+
Sbjct: 2030 SNTEGSFKCLCPEGFSLSSSGRRCQ 2054
Score = 73.3 bits (172), Expect = 7e-12
Identities = 63/220 (28%), Positives = 90/220 (40%), Gaps = 27/220 (12%)
Query: 304 CNAGEFKCNDGKCIPE--RWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLK 361
C + C +G+CIP +RC+ + G +L+ + I ++ CA C+
Sbjct: 453 CQLVRYLCQNGRCIPTPGSYRCECNK-----GFQLDLRGECIDVDECEKNPCAGGECINN 507
Query: 362 --TWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRK---H-VCDGM 415
++ C C G C D C + +N C+N H VC+
Sbjct: 508 QGSYTCQ----CRAGYQSTLTRTECR-DIDECLQNGRICNNG--RCINTDGSFHCVCNAG 560
Query: 416 KDCPRGDDEERCPLKRKCSAEEKC-EKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
R D + C +CS C +CI DG C C GF LA D C+DI+EC
Sbjct: 561 FHVTR--DGKNCEDMDECSIRNMCLNGMCINE-DGSFKCICKPGFQLASDGRYCKDINEC 617
Query: 475 MYEQDPVC-SQTCSNTVGSFRCGCMTGYILRPDERSCKPT 513
E +C + C NT GS+RC C G + D R C T
Sbjct: 618 --ETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDT 655
Score = 67.7 bits (158), Expect = 4e-10
Identities = 75/278 (26%), Positives = 96/278 (34%), Gaps = 39/278 (14%)
Query: 276 VPKDFQCDGDNDCGD---WTDEDSCPMVPGS----CNAGEFKCNDGKCIPERWRCD-NER 327
+P C ++C D D C +PG C G D K + CD N
Sbjct: 1230 MPDQRSCTDIDECEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPN 1289
Query: 328 DCADGGDELNCKPNSIRNCSLD------EYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNC 380
C G E N K + I +C + + C D C + C CTN C
Sbjct: 1290 ICLSGTCE-NTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKC 1348
Query: 381 EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKR-------KC 433
SC + + C N H+C DC RC K C
Sbjct: 1349 --SCSPGWIG----DGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGFTC 1402
Query: 434 SAEEKCEK---LC----ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTC 486
+ ++C + LC G C C MGF+ + D +C DIDEC V TC
Sbjct: 1403 TDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVFG-TC 1461
Query: 487 SNTVGSFRCGCMTGYILRPDERSCKPTGE--SPTLLFS 522
N G FRC C GY L +C E PT S
Sbjct: 1462 HNLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCIS 1499
Score = 65.7 bits (153), Expect = 1e-09
Identities = 32/83 (38%), Positives = 43/83 (51%), Gaps = 5/83 (6%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQT---CSNTVGSFRC 495
C C+ TY G C CP+G++L ED+ C+D DEC E C++ C N +G++ C
Sbjct: 2217 CAFRCVNTY-GSYECKCPVGYVLREDRRMCKDEDECE-EGKHDCTEKQMECKNLIGTYMC 2274
Query: 496 GCMTGYILRPDERSCKPTGESPT 518
C GY RPD C E T
Sbjct: 2275 ICGPGYQRRPDGEGCVDENECQT 2297
Score = 65.7 bits (153), Expect = 1e-09
Identities = 30/76 (39%), Positives = 43/76 (56%), Gaps = 3/76 (3%)
Query: 427 CPLKRKCS-AEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQT 485
C +C+ A + C +C T +G C+CP G++L ED SC+D+DEC +Q C
Sbjct: 2442 CVDLNECNQAPKPCNFICKNT-EGSYQCSCPKGYILQEDGRSCKDLDECATKQHN-CQFL 2499
Query: 486 CSNTVGSFRCGCMTGY 501
C NT+G F C C G+
Sbjct: 2500 CVNTIGGFTCKCPPGF 2515
Score = 64.5 bits (150), Expect = 3e-09
Identities = 66/231 (28%), Positives = 88/231 (38%), Gaps = 28/231 (12%)
Query: 293 DEDSCPMVPGSCN-------AGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRN 345
D D C +PG C G F+C +C + D C D DE P RN
Sbjct: 1766 DIDECREIPGVCENGVCINMVGSFRC---ECPVGFFYNDKLLVCEDI-DECQNGPVCQRN 1821
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNC 405
T RC K G R + G+ N C+E C + + + C
Sbjct: 1822 AECIN-TAGSYRCDCKP----GYRFTSTGQ--CNDRNECQEIPNICSHGQCIDTVGSFYC 1874
Query: 406 VNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDK 465
+ G K DD+ C +C + C T G C C GF+L+ +
Sbjct: 1875 LCHT----GFKT---NDDQTMCLDINECERDACGNGTCRNTI-GSFNCRCNHGFILSHNN 1926
Query: 466 YSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C D+DEC +C C NTVGSF+C C GY + PD R+C E
Sbjct: 1927 -DCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINE 1976
Score = 64.5 bits (150), Expect = 3e-09
Identities = 53/203 (26%), Positives = 79/203 (38%), Gaps = 19/203 (9%)
Query: 311 CND-GKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRR-CVLKTWLCDGV 368
C D +C ++ C GG C P ++ + +C D C LC
Sbjct: 2483 CKDLDECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHT----SCIDNNECTSDINLCGSK 2538
Query: 369 RDCTNGEDEMNCEV----SCEEDQYTCRPQEHLMSNAFRNCVNR-KHVCDGMK-DCPRGD 422
C N CE S ++ +C + N C + +++ G + CP+G
Sbjct: 2539 GICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGN--HRCQHGCQNIIGGYRCSCPQGY 2596
Query: 423 DEE----RCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQ 478
+ +C + +C + C G C CP GF + C+DI+EC Q
Sbjct: 2597 LQHYQWNQCVDENECLSAHICGGASCHNTLGSYKCMCPAGFQYEQFSGGCQDINECGSAQ 2656
Query: 479 DPVCSQTCSNTVGSFRCGCMTGY 501
P CS CSNT G + CGC GY
Sbjct: 2657 AP-CSYGCSNTEGGYLCGCPPGY 2678
Score = 63.7 bits (148), Expect = 6e-09
Identities = 71/269 (26%), Positives = 101/269 (37%), Gaps = 47/269 (17%)
Query: 270 CKNTKCV--PKDFQCDGDN--DCG-----DWTDEDSCPMVPGSCNAGEFKCNDG----KC 316
C +CV P DF+C D + G + D D C P C G +G +C
Sbjct: 1081 CGRGQCVNTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCEC 1140
Query: 317 IPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCV--LKTWLCDGVRDCTNG 374
P N C D I C L + C + RCV + + C +
Sbjct: 1141 PPGHQLSPNISACID-----------INECELSAHLCPNGRCVNLIGKYQCACNPGYHST 1189
Query: 375 EDEMNCEVSCEEDQYTCRPQEHLMSNAFRN-CVNRKHVCDGMKDCPRGDDEERCPLKRKC 433
D + C V +E C +M+ C N +G +C P +R C
Sbjct: 1190 PDRLFC-VDIDE----CS----IMNGGCETFCTNS----EGSYECSCQPGFALMPDQRSC 1236
Query: 434 SAEEKCE---KLC----ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTC 486
+ ++CE +C T G C C GF+ +ED +C D++EC + S TC
Sbjct: 1237 TDIDECEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTC 1296
Query: 487 SNTVGSFRCGCMTGYILRPDERSCKPTGE 515
NT GSF C C GY + + C E
Sbjct: 1297 ENTKGSFICHCDMGYSGKKGKTGCTDINE 1325
Score = 63.7 bits (148), Expect = 6e-09
Identities = 69/264 (26%), Positives = 98/264 (37%), Gaps = 25/264 (9%)
Query: 263 CAEIDFECKNTK--CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNA--GEFKCNDGKCIP 318
C + D EC+ K C K +C N G + C PG GE ++ +C
Sbjct: 2245 CKDED-ECEEGKHDCTEKQMECK--NLIGTYM----CICGPGYQRRPDGEGCVDENECQT 2297
Query: 319 ERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRR---CVLKTWLCDGVRDCTNGE 375
+ C+N R C + C+ N S ++ C D R C + +N
Sbjct: 2298 KPGICENGR-CLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRN 2356
Query: 376 DEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCD-GMKDCPRGDDEERCPLKRKCS 434
E C+ + H F+ V K +C G G D + C +
Sbjct: 2357 PVTKSECCCDGGRGW---GPHCEICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVC 2413
Query: 435 AEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFR 494
+C G C C G+ SC D++EC P C+ C NT GS++
Sbjct: 2414 RNGEC-----VNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKP-CNFICKNTEGSYQ 2467
Query: 495 CGCMTGYILRPDERSCKPTGESPT 518
C C GYIL+ D RSCK E T
Sbjct: 2468 CSCPKGYILQEDGRSCKDLDECAT 2491
Score = 60.9 bits (141), Expect = 4e-08
Identities = 36/102 (35%), Positives = 45/102 (44%), Gaps = 6/102 (5%)
Query: 417 DCPRGDD--EERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
+CP G C +CS C G C C GF +C DI+EC
Sbjct: 2152 ECPFGYTLAGNECVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPGP-MMTCEDINEC 2210
Query: 475 MYEQDPV-CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
Q+P+ C+ C NT GS+ C C GY+LR D R CK E
Sbjct: 2211 A--QNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDE 2250
Score = 59.3 bits (137), Expect = 1e-07
Identities = 36/113 (31%), Positives = 51/113 (45%), Gaps = 4/113 (3%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
CI T DG C C GF + D +C D+DEC ++ + C N GSF+C C G+
Sbjct: 546 CINT-DGSFHCVCNAGFHVTRDGKNCEDMDECSI-RNMCLNGMCINEDGSFKCICKPGFQ 603
Query: 503 LRPDERSCKPTG--ESPTLLFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYH 553
L D R CK E+P + + R + + + GL V +D H
Sbjct: 604 LASDGRYCKDINECETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTH 656
Score = 58.0 bits (134), Expect = 3e-07
Identities = 56/220 (25%), Positives = 80/220 (36%), Gaps = 19/220 (8%)
Query: 307 GEFKCND-GKCIPERWRCDNERDCAD--GGDELNCKPNSIRNCSLDEYTCADR-RCVLKT 362
G+ C D +C C C + G + +C P I D C D C T
Sbjct: 1316 GKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIG----DGIKCTDLDECSNGT 1371
Query: 363 WLCDGVRDCTN--GEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRK--HVCDGMK-D 417
+C DC N G C+ D +TC + N C N + + G + +
Sbjct: 1372 HMCSQHADCKNTMGSYRCLCKEGYTGDGFTCTDLDECSEN-LNLCGNGQCLNAPGGYRCE 1430
Query: 418 CPRG----DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDE 473
C G D + C +CS C G C C +G+ L +C D++E
Sbjct: 1431 CDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNE 1490
Query: 474 CMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPT 513
C+ + S C NT GS+ C C + L P C T
Sbjct: 1491 CL-DPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDT 1529
Score = 57.6 bits (133), Expect = 4e-07
Identities = 59/268 (22%), Positives = 104/268 (38%), Gaps = 24/268 (8%)
Query: 258 VELMRCAEIDFECKNTKCVPKD--FQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK 315
V++ C+ ++ C+ T C + ++C D+ SC + C C+ G+
Sbjct: 1196 VDIDECSIMNGGCE-TFCTNSEGSYECSCQPGFALMPDQRSCTDID-ECEDNPNICDGGQ 1253
Query: 316 C--IPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRC--VLKTWLCDGVRDC 371
C IP +RC D C + C L+ C C +++C
Sbjct: 1254 CTNIPGEYRCLCYDGFMASEDMKTCV--DVNECDLNPNICLSGTCENTKGSFICHCDMGY 1311
Query: 372 TNGEDEMNC-EVS-CEEDQYTCRPQEHLMSNA--FRNCVNRKHVCDGMKDCPRGDDEERC 427
+ + + C +++ CE + C + A F+ + + DG+K C D +E
Sbjct: 1312 SGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIK-CT--DLDECS 1368
Query: 428 PLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCS 487
CS C+ G C C G+ D ++C D+DEC + + C
Sbjct: 1369 NGTHMCSQHADCKNTM-----GSYRCLCKEGY--TGDGFTCTDLDECSENLNLCGNGQCL 1421
Query: 488 NTVGSFRCGCMTGYILRPDERSCKPTGE 515
N G +RC C G++ D ++C+ E
Sbjct: 1422 NAPGGYRCECDMGFVPSADGKACEDIDE 1449
Score = 57.6 bits (133), Expect = 4e-07
Identities = 72/269 (26%), Positives = 98/269 (36%), Gaps = 27/269 (10%)
Query: 259 ELMRCAEIDFECKNTKCV--PKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKC 316
+L C+E C N +C+ P ++C+ D D +C + C+ C G C
Sbjct: 1404 DLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDID-ECSLPNI-CVFGTC 1461
Query: 317 --IPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLK--TWLCDGVRDCT 372
+P +RC+ E NC + C LD TC CV +++CD D
Sbjct: 1462 HNLPGLFRCECEIGYELDRSGGNC--TDVNEC-LDPTTCISGNCVNTPGSYICDCPPDFE 1518
Query: 373 NGEDEMNCEVSCEEDQYT-CRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKR 431
+ C + + Y RP+ N C N V C C L +
Sbjct: 1519 LNPTRVGCVDTRSGNCYLDIRPRG---DNGDTACSNEIGVGVSKASCC-------CSLGK 1568
Query: 432 KCSAEEKCEKL-CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNT 489
CE + T + C GF DIDEC E +C C NT
Sbjct: 1569 AWGTP--CEMCPAVNTSEYKILCPGGEGFRPNPITVILEDIDECQ-ELPGLCQGGKCINT 1625
Query: 490 VGSFRCGCMTGYILRPDERSCKPTGESPT 518
GSF+C C TGY L D R C E T
Sbjct: 1626 FGSFQCRCPTGYYLNEDTRVCDDVNECET 1654
Score = 57.2 bits (132), Expect = 5e-07
Identities = 46/175 (26%), Positives = 70/175 (40%), Gaps = 16/175 (9%)
Query: 352 TCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVS--CEEDQYTCRPQEHLMS---NAFRNC 405
+C D C C+ + T G + +C +ED +C+ + + N C
Sbjct: 2441 SCVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQFLC 2500
Query: 406 VNRKHVCDGMKDCPRGDDEER--CPLKRKCSAE-EKC--EKLCITTYDGHAACACPMGFL 460
VN + CP G + C +C+++ C + +C T G C C GF
Sbjct: 2501 VNT--IGGFTCKCPPGFTQHHTSCIDNNECTSDINLCGSKGICQNT-PGSFTCECQRGFS 2557
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
L + SC D+DEC E + C C N +G +RC C GY+ C E
Sbjct: 2558 LDQTGSSCEDVDEC--EGNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENE 2610
Score = 56.4 bits (130), Expect = 9e-07
Identities = 26/65 (40%), Positives = 32/65 (49%), Gaps = 2/65 (3%)
Query: 449 GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDER 508
G C CP GF+ D +C DIDEC E P + C N+ GSF C C + L P +
Sbjct: 786 GSFVCTCPKGFIYKPDLKTCEDIDEC--ESSPCINGVCKNSPGSFICECSSESTLDPTKT 843
Query: 509 SCKPT 513
C T
Sbjct: 844 ICIET 848
Score = 55.6 bits (128), Expect = 2e-06
Identities = 31/94 (32%), Positives = 46/94 (48%), Gaps = 9/94 (9%)
Query: 429 LKRKCSAEEKCEKL------CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC 482
L+ +C ++CEK CI G C C G+ + CRDIDEC+ + +C
Sbjct: 484 LRGECIDVDECEKNPCAGGECINN-QGSYTCQCRAGYQSTLTRTECRDIDECL-QNGRIC 541
Query: 483 SQ-TCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
+ C NT GSF C C G+ + D ++C+ E
Sbjct: 542 NNGRCINTDGSFHCVCNAGFHVTRDGKNCEDMDE 575
Score = 55.6 bits (128), Expect = 2e-06
Identities = 61/264 (23%), Positives = 97/264 (36%), Gaps = 25/264 (9%)
Query: 264 AEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDS-CPMVPGSCNAGEFKCNDGKCIPERWR 322
A+ID ECK V ++ +C D + P + G+ +CN P +
Sbjct: 2401 ADID-ECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPK-PCNFI 2458
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADR-RCVLKTWLCDGVRDCTNGEDEMNCE 381
C N +G + +C I D +C D C K C + T G C
Sbjct: 2459 CKN----TEGSYQCSCPKGYI--LQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCP 2512
Query: 382 VSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMK-----DCPRGDDEER----CPLKRK 432
+ +C S+ N K +C +C RG ++ C +
Sbjct: 2513 PGFTQHHTSCIDNNECTSDI--NLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDE 2570
Query: 433 CSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCS-QTCSNTVG 491
C +C+ C G+ C+CP G+L C D +EC+ +C +C NT+G
Sbjct: 2571 CEGNHRCQHGCQNIIGGYR-CSCPQGYLQHYQWNQCVDENECLSAH--ICGGASCHNTLG 2627
Query: 492 SFRCGCMTGYILRPDERSCKPTGE 515
S++C C G+ C+ E
Sbjct: 2628 SYKCMCPAGFQYEQFSGGCQDINE 2651
Score = 54.8 bits (126), Expect = 3e-06
Identities = 70/261 (26%), Positives = 106/261 (40%), Gaps = 33/261 (12%)
Query: 272 NTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDG-KCIPERWRCDNERDCA 330
N C+ D +C N G+ C GS +CN+G + P+ C + +C
Sbjct: 1925 NNDCIDVD-ECASGN--GNLCRNGQCINTVGSFQC---QCNEGYEVAPDGRTCVDINECL 1978
Query: 331 DGGDELNCKPNSIRNCSLDEYTC-ADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCE--ED 387
+ C P + +N Y C L+ C+ + +C E E+ +C E
Sbjct: 1979 L--EPRKCAPGTCQNLD-GSYRCICPPGYSLQNEKCEDIDECVE-EPEICALGTCSNTEG 2034
Query: 388 QYTCR-PQEHLMSNAFRNCVN-RKHVC-----DGMKDCPRGDDEER----CPLKRKCSAE 436
+ C P+ +S++ R C + R C G P+ + + C LK +
Sbjct: 2035 SFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGE-GWG 2093
Query: 437 EKCEKLCITTYDGHAACACPMGF-LLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFR 494
+ CE LC T D CP G ++ S D+DEC ++ VC C NT GS+R
Sbjct: 2094 DPCE-LCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDEC--KEPDVCKHGQCINTDGSYR 2150
Query: 495 CGCMTGYILRPDERSCKPTGE 515
C C GY L +E C T E
Sbjct: 2151 CECPFGYTLAGNE--CVDTDE 2169
Score = 53.6 bits (123), Expect = 6e-06
Identities = 27/68 (39%), Positives = 30/68 (44%), Gaps = 1/68 (1%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
CI T G C CP G L E C DIDEC C+NTV S+ C C G+
Sbjct: 262 CINTV-GSFECKCPAGHKLNEVSQKCEDIDECSTIPGICEGGECTNTVSSYFCKCPPGFY 320
Query: 503 LRPDERSC 510
PD C
Sbjct: 321 TSPDGTRC 328
Score = 53.2 bits (122), Expect = 8e-06
Identities = 30/95 (31%), Positives = 41/95 (43%), Gaps = 5/95 (5%)
Query: 421 GDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP 480
G D C L CE L G C C G+ + +C DI+EC+
Sbjct: 721 GSDINECALDPDICPNGICENL-----RGTYKCICNSGYEVDSTGKNCVDINECVLNSLL 775
Query: 481 VCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
+ C NT GSF C C G+I +PD ++C+ E
Sbjct: 776 CDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDE 810
Score = 48.0 bits (109), Expect = 3e-04
Identities = 45/179 (25%), Positives = 64/179 (35%), Gaps = 23/179 (12%)
Query: 351 YTCADRRCVLKTWLCDGVRDCTNGEDEM---NCEVSCEEDQYTCRPQEHLMSNAFRNCVN 407
YT A CV T C C NG + E +CEE P + C
Sbjct: 2157 YTLAGNECV-DTDECSVGNPCGNGTCKNVIGGFECTCEEG---FEPGPMMTCEDINECAQ 2212
Query: 408 RKHVCDGMKDCPRGDDEERCPL-------KRKCSAEEKCEK---------LCITTYDGHA 451
+C G E +CP+ +R C E++CE+ + G
Sbjct: 2213 NPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTY 2272
Query: 452 ACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSC 510
C C G+ D C D +EC + + C NT GS+ C C G+ P++ C
Sbjct: 2273 MCICGPGYQRRPDGEGCVDENECQTKPGICENGRCLNTRGSYTCECNDGFTASPNQDEC 2331
Score = 46.4 bits (105), Expect = 0.001
Identities = 22/65 (33%), Positives = 30/65 (46%)
Query: 455 CPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTG 514
C GF+ +C+D+DEC C NTVGSF C C G+ L + C+
Sbjct: 231 CRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKCEDID 290
Query: 515 ESPTL 519
E T+
Sbjct: 291 ECSTI 295
Score = 44.8 bits (101), Expect = 0.003
Identities = 27/83 (32%), Positives = 39/83 (46%), Gaps = 4/83 (4%)
Query: 437 EKCEKLCI-TTYDGHAACACPMGFLLAE---DKYSCRDIDECMYEQDPVCSQTCSNTVGS 492
E+CE+ + T + C GF E K +DI+EC C NT+GS
Sbjct: 991 EECEECPMRNTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPSLCTHGKCRNTIGS 1050
Query: 493 FRCGCMTGYILRPDERSCKPTGE 515
F+C C +G+ L +ER+C E
Sbjct: 1051 FKCRCDSGFALDSEERNCTDIDE 1073
Score = 38.3 bits (85), Expect = 0.25
Identities = 18/43 (41%), Positives = 21/43 (48%)
Query: 468 CRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSC 510
C DIDEC + C NT GSF+C C +G L R C
Sbjct: 908 CEDIDECEVFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRIC 950
Score = 36.3 bits (80), Expect = 1.00
Identities = 18/48 (37%), Positives = 24/48 (50%), Gaps = 5/48 (10%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTG---MPFEKSTTDQTPKKCKSHP 1366
C NGGC C S Y C+C G MP ++S TD +C+ +P
Sbjct: 1201 CSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTD--IDECEDNP 1246
Score = 36.3 bits (80), Expect = 1.00
Identities = 14/38 (36%), Positives = 17/38 (44%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NGGC C G C+C G L D ++C D
Sbjct: 1201 CSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTD 1238
Score = 36.3 bits (80), Expect = 1.00
Identities = 16/39 (41%), Positives = 20/39 (51%), Gaps = 1/39 (2%)
Query: 1019 CGKNNGGCSH-LCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C +N C + CL PGG C C +G + DGK C D
Sbjct: 1408 CSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACED 1446
Score = 35.5 bits (78), Expect = 1.7
Identities = 13/38 (34%), Positives = 20/38 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C + C+ +C G C+CP G L +DG++C D
Sbjct: 2448 CNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSCKD 2485
Score = 33.9 bits (74), Expect = 5.3
Identities = 13/38 (34%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C +N C+ C+ G C CP+G L +D + C D
Sbjct: 2210 CAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKD 2247
Score = 33.5 bits (73), Expect = 7.0
Identities = 12/28 (42%), Positives = 15/28 (53%)
Query: 1320 NACGTDNGGCSHLCLRSPLGYTCACPTG 1347
N CG+ CS+ C + GY C CP G
Sbjct: 2650 NECGSAQAPCSYGCSNTEGGYLCGCPPG 2677
>AB177803-1|BAD16739.1| 2871|Homo sapiens fibrillin 1 protein.
Length = 2871
Score = 78.2 bits (184), Expect = 3e-13
Identities = 73/269 (27%), Positives = 107/269 (39%), Gaps = 25/269 (9%)
Query: 259 ELMRCAEIDFECKNTKC--VPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKC 316
++ C I C + KC F+C D+ ++E +C + C C G+C
Sbjct: 1028 DINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDID-ECRISPDLCGRGQC 1086
Query: 317 I--PERWRCDNERDCADGGDEL-NCKPNSIRNCSLDEYTCADRRC--VLKTWLCDGVRDC 371
+ P + C + G + NC I C D C C ++ C+ C
Sbjct: 1087 VNTPGDFECKCDEGYESGFMMMKNCM--DIDECQRDPLLCRGGVCHNTEGSYRCE----C 1140
Query: 372 TNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNR--KHVCDGMKDCPRGDDEERCPL 429
G +++ +S D C HL N CVN K+ C D C
Sbjct: 1141 PPGH-QLSPNISACIDINECELSAHLCPNG--RCVNLIGKYQCACNPGYHSTPDRLFCVD 1197
Query: 430 KRKCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VC-SQTC 486
+CS CE C T +G C+C GF L D+ SC DIDEC E +P +C C
Sbjct: 1198 IDECSIMNGGCETFC-TNSEGSYECSCQPGFALMPDQRSCTDIDEC--EDNPNICDGGQC 1254
Query: 487 SNTVGSFRCGCMTGYILRPDERSCKPTGE 515
+N G +RC C G++ D ++C E
Sbjct: 1255 TNIPGEYRCLCYDGFMASEDMKTCVDVNE 1283
Score = 74.9 bits (176), Expect = 2e-12
Identities = 63/218 (28%), Positives = 88/218 (40%), Gaps = 23/218 (10%)
Query: 304 CNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLK-- 361
C + C +G+CIP C E + G +L+ + I ++ CA C+
Sbjct: 453 CQLVRYLCQNGRCIPTPGSCRCE---CNKGFQLDLRGECIDVDECEKNPCAGGECINNQG 509
Query: 362 TWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRK---H-VCDGMKD 417
++ C C G C D C + +N C+N H VC+
Sbjct: 510 SYTCQ----CRAGYQSTLTRTECR-DIDECLQNGRICNNG--RCINTDGSFHCVCNAGFH 562
Query: 418 CPRGDDEERCPLKRKCSAEEKC-EKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMY 476
R D + C +CS C +CI DG C C GF LA D C+DI+EC
Sbjct: 563 VTR--DGKNCEDMDECSIRNMCLNGMCINE-DGSFKCICKPGFQLASDGRYCKDINEC-- 617
Query: 477 EQDPVC-SQTCSNTVGSFRCGCMTGYILRPDERSCKPT 513
E +C + C NT GS+RC C G + D R C T
Sbjct: 618 ETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDT 655
Score = 74.9 bits (176), Expect = 2e-12
Identities = 73/265 (27%), Positives = 99/265 (37%), Gaps = 24/265 (9%)
Query: 259 ELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIP 318
+L+ C +ID EC+N ++ +C N G + C PG +CND
Sbjct: 1802 KLLVCEDID-ECQNGPVCQRNAECI--NTAGSYR----CDCKPGYRFTSTGQCNDRNECQ 1854
Query: 319 ERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDE 377
E + C D C ++ + D+ C D C C G C N
Sbjct: 1855 EIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDINECERDA--C-GNGTCRNTIGS 1911
Query: 378 MNCEVS---CEEDQYTCRPQEHLMS---NAFRN--CVNR--KHVCDGMKDCPRGDDEERC 427
NC + C + S N RN C+N C + D C
Sbjct: 1912 FNCRCNHGFILSHNNDCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTC 1971
Query: 428 PLKRKCSAE-EKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTC 486
+C E KC DG C CP G+ L +K C DIDEC+ E + TC
Sbjct: 1972 VDINECLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNEK--CEDIDECVEEPEICALGTC 2029
Query: 487 SNTVGSFRCGCMTGYILRPDERSCK 511
SNT GSF+C C G+ L R C+
Sbjct: 2030 SNTEGSFKCLCPEGFSLSSSGRRCQ 2054
Score = 67.7 bits (158), Expect = 4e-10
Identities = 75/278 (26%), Positives = 96/278 (34%), Gaps = 39/278 (14%)
Query: 276 VPKDFQCDGDNDCGD---WTDEDSCPMVPGS----CNAGEFKCNDGKCIPERWRCD-NER 327
+P C ++C D D C +PG C G D K + CD N
Sbjct: 1230 MPDQRSCTDIDECEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPN 1289
Query: 328 DCADGGDELNCKPNSIRNCSLD------EYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNC 380
C G E N K + I +C + + C D C + C CTN C
Sbjct: 1290 ICLSGTCE-NTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKC 1348
Query: 381 EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKR-------KC 433
SC + + C N H+C DC RC K C
Sbjct: 1349 --SCSPGWIG----DGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGFTC 1402
Query: 434 SAEEKCEK---LC----ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTC 486
+ ++C + LC G C C MGF+ + D +C DIDEC V TC
Sbjct: 1403 TDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVFG-TC 1461
Query: 487 SNTVGSFRCGCMTGYILRPDERSCKPTGE--SPTLLFS 522
N G FRC C GY L +C E PT S
Sbjct: 1462 HNLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCIS 1499
Score = 65.7 bits (153), Expect = 1e-09
Identities = 32/83 (38%), Positives = 43/83 (51%), Gaps = 5/83 (6%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ---TCSNTVGSFRC 495
C C+ TY G C CP+G++L ED+ C+D DEC E C++ C N +G++ C
Sbjct: 2217 CAFRCVNTY-GSYECKCPVGYVLREDRRMCKDEDEC-EEGKHDCTEKQMECKNLIGTYMC 2274
Query: 496 GCMTGYILRPDERSCKPTGESPT 518
C GY RPD C E T
Sbjct: 2275 ICGPGYQRRPDGEGCVDENECQT 2297
Score = 65.7 bits (153), Expect = 1e-09
Identities = 30/76 (39%), Positives = 43/76 (56%), Gaps = 3/76 (3%)
Query: 427 CPLKRKCS-AEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQT 485
C +C+ A + C +C T +G C+CP G++L ED SC+D+DEC +Q C
Sbjct: 2442 CVDLNECNQAPKPCNFICKNT-EGSYQCSCPKGYILQEDGRSCKDLDECATKQHN-CQFL 2499
Query: 486 CSNTVGSFRCGCMTGY 501
C NT+G F C C G+
Sbjct: 2500 CVNTIGGFTCKCPPGF 2515
Score = 64.5 bits (150), Expect = 3e-09
Identities = 66/231 (28%), Positives = 88/231 (38%), Gaps = 28/231 (12%)
Query: 293 DEDSCPMVPGSCN-------AGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRN 345
D D C +PG C G F+C +C + D C D DE P RN
Sbjct: 1766 DIDECREIPGVCENGVCINMVGSFRC---ECPVGFFYNDKLLVCEDI-DECQNGPVCQRN 1821
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNC 405
T RC K G R + G+ N C+E C + + + C
Sbjct: 1822 AECIN-TAGSYRCDCKP----GYRFTSTGQ--CNDRNECQEIPNICSHGQCIDTVGSFYC 1874
Query: 406 VNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDK 465
+ G K DD+ C +C + C T G C C GF+L+ +
Sbjct: 1875 LCHT----GFKT---NDDQTMCLDINECERDACGNGTCRNTI-GSFNCRCNHGFILSHNN 1926
Query: 466 YSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C D+DEC +C C NTVGSF+C C GY + PD R+C E
Sbjct: 1927 -DCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINE 1976
Score = 63.7 bits (148), Expect = 6e-09
Identities = 71/269 (26%), Positives = 101/269 (37%), Gaps = 47/269 (17%)
Query: 270 CKNTKCV--PKDFQCDGDN--DCG-----DWTDEDSCPMVPGSCNAGEFKCNDG----KC 316
C +CV P DF+C D + G + D D C P C G +G +C
Sbjct: 1081 CGRGQCVNTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCEC 1140
Query: 317 IPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCV--LKTWLCDGVRDCTNG 374
P N C D I C L + C + RCV + + C +
Sbjct: 1141 PPGHQLSPNISACID-----------INECELSAHLCPNGRCVNLIGKYQCACNPGYHST 1189
Query: 375 EDEMNCEVSCEEDQYTCRPQEHLMSNAFRN-CVNRKHVCDGMKDCPRGDDEERCPLKRKC 433
D + C V +E C +M+ C N +G +C P +R C
Sbjct: 1190 PDRLFC-VDIDE----CS----IMNGGCETFCTNS----EGSYECSCQPGFALMPDQRSC 1236
Query: 434 SAEEKCE---KLC----ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTC 486
+ ++CE +C T G C C GF+ +ED +C D++EC + S TC
Sbjct: 1237 TDIDECEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTC 1296
Query: 487 SNTVGSFRCGCMTGYILRPDERSCKPTGE 515
NT GSF C C GY + + C E
Sbjct: 1297 ENTKGSFICHCDMGYSGKKGKTGCTDINE 1325
Score = 63.7 bits (148), Expect = 6e-09
Identities = 69/264 (26%), Positives = 98/264 (37%), Gaps = 25/264 (9%)
Query: 263 CAEIDFECKNTK--CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNA--GEFKCNDGKCIP 318
C + D EC+ K C K +C N G + C PG GE ++ +C
Sbjct: 2245 CKDED-ECEEGKHDCTEKQMECK--NLIGTYM----CICGPGYQRRPDGEGCVDENECQT 2297
Query: 319 ERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRR---CVLKTWLCDGVRDCTNGE 375
+ C+N R C + C+ N S ++ C D R C + +N
Sbjct: 2298 KPGICENGR-CLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRN 2356
Query: 376 DEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCD-GMKDCPRGDDEERCPLKRKCS 434
E C+ + H F+ V K +C G G D + C +
Sbjct: 2357 PVTKSECCCDGGRGW---GPHCEICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVC 2413
Query: 435 AEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFR 494
+C G C C G+ SC D++EC P C+ C NT GS++
Sbjct: 2414 RNGEC-----VNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKP-CNFICKNTEGSYQ 2467
Query: 495 CGCMTGYILRPDERSCKPTGESPT 518
C C GYIL+ D RSCK E T
Sbjct: 2468 CSCPKGYILQEDGRSCKDLDECAT 2491
Score = 60.5 bits (140), Expect = 5e-08
Identities = 55/214 (25%), Positives = 83/214 (38%), Gaps = 16/214 (7%)
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSC----EEDQYTCRPQEHLMSNA 401
C L Y C + RC+ C +C G +++ C E ++ C E + +
Sbjct: 453 CQLVRYLCQNGRCIPTPGSCRC--ECNKGF-QLDLRGECIDVDECEKNPCAGGECINNQG 509
Query: 402 FRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLL 461
C R + D +E R C+ CI T DG C C GF +
Sbjct: 510 SYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGR-----CINT-DGSFHCVCNAGFHV 563
Query: 462 AEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTG--ESPTL 519
D +C D+DEC ++ + C N GSF+C C G+ L D R CK E+P +
Sbjct: 564 TRDGKNCEDMDECSI-RNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPGI 622
Query: 520 LFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYH 553
+ R + + + GL V +D H
Sbjct: 623 CMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTH 656
Score = 60.5 bits (140), Expect = 5e-08
Identities = 36/102 (35%), Positives = 45/102 (44%), Gaps = 6/102 (5%)
Query: 417 DCPRGD--DEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
+CP G C +CS C G C C GF +C DI+EC
Sbjct: 2152 ECPFGYILAGNECVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPGP-MMTCEDINEC 2210
Query: 475 MYEQDPV-CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
Q+P+ C+ C NT GS+ C C GY+LR D R CK E
Sbjct: 2211 A--QNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDE 2250
Score = 60.5 bits (140), Expect = 5e-08
Identities = 52/203 (25%), Positives = 78/203 (38%), Gaps = 19/203 (9%)
Query: 311 CND-GKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRR-CVLKTWLCDGV 368
C D +C ++ C GG C P ++ + +C D C LC
Sbjct: 2483 CKDLDECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHT----SCIDNNECTSDINLCGSK 2538
Query: 369 RDCTNGEDEMNCEV----SCEEDQYTCRPQEHLMSNAFRNCVNR-KHVCDGMK-DCPRGD 422
C N CE S ++ +C + N C + +++ G + CP+G
Sbjct: 2539 GICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGN--HRCQHGCQNIIGGYRCSCPQGY 2596
Query: 423 DEE----RCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQ 478
+ +C + +C + C G C CP GF + C+DI+EC Q
Sbjct: 2597 LQHYQWNQCVDENECLSAHICGGASCHNTLGSYKCMCPAGFQYEQFSGGCQDINECGSAQ 2656
Query: 479 DPVCSQTCSNTVGSFRCGCMTGY 501
P CS SNT G + CGC GY
Sbjct: 2657 AP-CSYGSSNTEGGYLCGCPPGY 2678
Score = 58.0 bits (134), Expect = 3e-07
Identities = 56/220 (25%), Positives = 80/220 (36%), Gaps = 19/220 (8%)
Query: 307 GEFKCND-GKCIPERWRCDNERDCAD--GGDELNCKPNSIRNCSLDEYTCADR-RCVLKT 362
G+ C D +C C C + G + +C P I D C D C T
Sbjct: 1316 GKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIG----DGIKCTDLDECSNGT 1371
Query: 363 WLCDGVRDCTN--GEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRK--HVCDGMK-D 417
+C DC N G C+ D +TC + N C N + + G + +
Sbjct: 1372 HMCSQHADCKNTMGSYRCLCKEGYTGDGFTCTDLDECSEN-LNLCGNGQCLNAPGGYRCE 1430
Query: 418 CPRG----DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDE 473
C G D + C +CS C G C C +G+ L +C D++E
Sbjct: 1431 CDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNE 1490
Query: 474 CMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPT 513
C+ + S C NT GS+ C C + L P C T
Sbjct: 1491 CL-DPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDT 1529
Score = 57.6 bits (133), Expect = 4e-07
Identities = 59/268 (22%), Positives = 104/268 (38%), Gaps = 24/268 (8%)
Query: 258 VELMRCAEIDFECKNTKCVPKD--FQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK 315
V++ C+ ++ C+ T C + ++C D+ SC + C C+ G+
Sbjct: 1196 VDIDECSIMNGGCE-TFCTNSEGSYECSCQPGFALMPDQRSCTDID-ECEDNPNICDGGQ 1253
Query: 316 C--IPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRC--VLKTWLCDGVRDC 371
C IP +RC D C + C L+ C C +++C
Sbjct: 1254 CTNIPGEYRCLCYDGFMASEDMKTCV--DVNECDLNPNICLSGTCENTKGSFICHCDMGY 1311
Query: 372 TNGEDEMNC-EVS-CEEDQYTCRPQEHLMSNA--FRNCVNRKHVCDGMKDCPRGDDEERC 427
+ + + C +++ CE + C + A F+ + + DG+K C D +E
Sbjct: 1312 SGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIK-CT--DLDECS 1368
Query: 428 PLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCS 487
CS C+ G C C G+ D ++C D+DEC + + C
Sbjct: 1369 NGTHMCSQHADCKNTM-----GSYRCLCKEGY--TGDGFTCTDLDECSENLNLCGNGQCL 1421
Query: 488 NTVGSFRCGCMTGYILRPDERSCKPTGE 515
N G +RC C G++ D ++C+ E
Sbjct: 1422 NAPGGYRCECDMGFVPSADGKACEDIDE 1449
Score = 57.6 bits (133), Expect = 4e-07
Identities = 72/269 (26%), Positives = 98/269 (36%), Gaps = 27/269 (10%)
Query: 259 ELMRCAEIDFECKNTKCV--PKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKC 316
+L C+E C N +C+ P ++C+ D D +C + C+ C G C
Sbjct: 1404 DLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDID-ECSLPNI-CVFGTC 1461
Query: 317 --IPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLK--TWLCDGVRDCT 372
+P +RC+ E NC + C LD TC CV +++CD D
Sbjct: 1462 HNLPGLFRCECEIGYELDRSGGNC--TDVNEC-LDPTTCISGNCVNTPGSYICDCPPDFE 1518
Query: 373 NGEDEMNCEVSCEEDQYT-CRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKR 431
+ C + + Y RP+ N C N V C C L +
Sbjct: 1519 LNPTRVGCVDTRSGNCYLDIRPRG---DNGDTACSNEIGVGVSKASCC-------CSLGK 1568
Query: 432 KCSAEEKCEKL-CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNT 489
CE + T + C GF DIDEC E +C C NT
Sbjct: 1569 AWGTP--CEMCPAVNTSEYKILCPGGEGFRPNPITVILEDIDECQ-ELPGLCQGGKCINT 1625
Query: 490 VGSFRCGCMTGYILRPDERSCKPTGESPT 518
GSF+C C TGY L D R C E T
Sbjct: 1626 FGSFQCRCPTGYYLNEDTRVCDDVNECET 1654
Score = 57.2 bits (132), Expect = 5e-07
Identities = 46/175 (26%), Positives = 70/175 (40%), Gaps = 16/175 (9%)
Query: 352 TCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVS--CEEDQYTCRPQEHLMS---NAFRNC 405
+C D C C+ + T G + +C +ED +C+ + + N C
Sbjct: 2441 SCVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQFLC 2500
Query: 406 VNRKHVCDGMKDCPRGDDEER--CPLKRKCSAE-EKC--EKLCITTYDGHAACACPMGFL 460
VN + CP G + C +C+++ C + +C T G C C GF
Sbjct: 2501 VNT--IGGFTCKCPPGFTQHHTSCIDNNECTSDINLCGSKGICQNT-PGSFTCECQRGFS 2557
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
L + SC D+DEC E + C C N +G +RC C GY+ C E
Sbjct: 2558 LDQTGSSCEDVDEC--EGNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENE 2610
Score = 56.8 bits (131), Expect = 7e-07
Identities = 71/261 (27%), Positives = 107/261 (40%), Gaps = 33/261 (12%)
Query: 272 NTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDG-KCIPERWRCDNERDCA 330
N C+ D +C N G+ C GS +CN+G + P+ C + +C
Sbjct: 1925 NNDCIDVD-ECASGN--GNLCRNGQCINTVGSFQC---QCNEGYEVAPDGRTCVDINECL 1978
Query: 331 DGGDELNCKPNSIRNCSLDEYTC-ADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCE--ED 387
+ C P + +N Y C L+ C+ + +C E E+ +C E
Sbjct: 1979 L--EPRKCAPGTCQNLD-GSYRCICPPGYSLQNEKCEDIDECVE-EPEICALGTCSNTEG 2034
Query: 388 QYTCR-PQEHLMSNAFRNCVN-RKHVC-----DGMKDCPRGDDEER----CPLKRKCSAE 436
+ C P+ +S++ R C + R C G P+ + + C LK +
Sbjct: 2035 SFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGE-GWG 2093
Query: 437 EKCEKLCITTYDGHAACACPMGF-LLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFR 494
+ CE LC T D CP G ++ S D+DEC ++ VC C NT GS+R
Sbjct: 2094 DPCE-LCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDEC--KEPDVCKHGQCINTDGSYR 2150
Query: 495 CGCMTGYILRPDERSCKPTGE 515
C C GYIL +E C T E
Sbjct: 2151 CECPFGYILAGNE--CVDTDE 2169
Score = 56.4 bits (130), Expect = 9e-07
Identities = 26/65 (40%), Positives = 32/65 (49%), Gaps = 2/65 (3%)
Query: 449 GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDER 508
G C CP GF+ D +C DIDEC E P + C N+ GSF C C + L P +
Sbjct: 786 GSFVCTCPKGFIYKPDLKTCEDIDEC--ESSPCINGVCKNSPGSFICECSSESTLDPTKT 843
Query: 509 SCKPT 513
C T
Sbjct: 844 ICIET 848
Score = 55.6 bits (128), Expect = 2e-06
Identities = 61/264 (23%), Positives = 97/264 (36%), Gaps = 25/264 (9%)
Query: 264 AEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDS-CPMVPGSCNAGEFKCNDGKCIPERWR 322
A+ID ECK V ++ +C D + P + G+ +CN P +
Sbjct: 2401 ADID-ECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPK-PCNFI 2458
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADR-RCVLKTWLCDGVRDCTNGEDEMNCE 381
C N +G + +C I D +C D C K C + T G C
Sbjct: 2459 CKN----TEGSYQCSCPKGYI--LQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCP 2512
Query: 382 VSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMK-----DCPRGDDEER----CPLKRK 432
+ +C S+ N K +C +C RG ++ C +
Sbjct: 2513 PGFTQHHTSCIDNNECTSDI--NLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDE 2570
Query: 433 CSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCS-QTCSNTVG 491
C +C+ C G+ C+CP G+L C D +EC+ +C +C NT+G
Sbjct: 2571 CEGNHRCQHGCQNIIGGYR-CSCPQGYLQHYQWNQCVDENECLSAH--ICGGASCHNTLG 2627
Query: 492 SFRCGCMTGYILRPDERSCKPTGE 515
S++C C G+ C+ E
Sbjct: 2628 SYKCMCPAGFQYEQFSGGCQDINE 2651
Score = 53.6 bits (123), Expect = 6e-06
Identities = 27/68 (39%), Positives = 30/68 (44%), Gaps = 1/68 (1%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
CI T G C CP G L E C DIDEC C+NTV S+ C C G+
Sbjct: 262 CINTV-GSFECKCPAGHKLNEVSQKCEDIDECSTIPGICEGGECTNTVSSYFCKCPPGFY 320
Query: 503 LRPDERSC 510
PD C
Sbjct: 321 TSPDGTRC 328
Score = 53.2 bits (122), Expect = 8e-06
Identities = 30/95 (31%), Positives = 41/95 (43%), Gaps = 5/95 (5%)
Query: 421 GDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP 480
G D C L CE L G C C G+ + +C DI+EC+
Sbjct: 721 GSDINECALDPDICPNGICENL-----RGTYKCICNSGYEVDSTGKNCVDINECVLNSLL 775
Query: 481 VCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
+ C NT GSF C C G+I +PD ++C+ E
Sbjct: 776 CDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDE 810
Score = 46.4 bits (105), Expect = 0.001
Identities = 22/65 (33%), Positives = 30/65 (46%)
Query: 455 CPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTG 514
C GF+ +C+D+DEC C NTVGSF C C G+ L + C+
Sbjct: 231 CRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKCEDID 290
Query: 515 ESPTL 519
E T+
Sbjct: 291 ECSTI 295
Score = 44.8 bits (101), Expect = 0.003
Identities = 27/83 (32%), Positives = 39/83 (46%), Gaps = 4/83 (4%)
Query: 437 EKCEKLCI-TTYDGHAACACPMGFLLAE---DKYSCRDIDECMYEQDPVCSQTCSNTVGS 492
E+CE+ + T + C GF E K +DI+EC C NT+GS
Sbjct: 991 EECEECPMRNTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPSLCTHGKCRNTIGS 1050
Query: 493 FRCGCMTGYILRPDERSCKPTGE 515
F+C C +G+ L +ER+C E
Sbjct: 1051 FKCRCDSGFALDSEERNCTDIDE 1073
Score = 38.3 bits (85), Expect = 0.25
Identities = 18/43 (41%), Positives = 21/43 (48%)
Query: 468 CRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSC 510
C DIDEC + C NT GSF+C C +G L R C
Sbjct: 908 CEDIDECEVFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRIC 950
Score = 36.3 bits (80), Expect = 1.00
Identities = 18/48 (37%), Positives = 24/48 (50%), Gaps = 5/48 (10%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTG---MPFEKSTTDQTPKKCKSHP 1366
C NGGC C S Y C+C G MP ++S TD +C+ +P
Sbjct: 1201 CSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTD--IDECEDNP 1246
Score = 36.3 bits (80), Expect = 1.00
Identities = 14/38 (36%), Positives = 17/38 (44%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NGGC C G C+C G L D ++C D
Sbjct: 1201 CSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTD 1238
Score = 36.3 bits (80), Expect = 1.00
Identities = 16/39 (41%), Positives = 20/39 (51%), Gaps = 1/39 (2%)
Query: 1019 CGKNNGGCSH-LCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C +N C + CL PGG C C +G + DGK C D
Sbjct: 1408 CSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACED 1446
Score = 35.5 bits (78), Expect = 1.7
Identities = 13/38 (34%), Positives = 20/38 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C + C+ +C G C+CP G L +DG++C D
Sbjct: 2448 CNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSCKD 2485
Score = 33.9 bits (74), Expect = 5.3
Identities = 13/38 (34%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C +N C+ C+ G C CP+G L +D + C D
Sbjct: 2210 CAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKD 2247
>AB177802-1|BAD16738.1| 1365|Homo sapiens fibrillin 1 protein.
Length = 1365
Score = 78.2 bits (184), Expect = 3e-13
Identities = 73/269 (27%), Positives = 107/269 (39%), Gaps = 25/269 (9%)
Query: 259 ELMRCAEIDFECKNTKC--VPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKC 316
++ C I C + KC F+C D+ ++E +C + C C G+C
Sbjct: 1028 DINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDID-ECRISPDLCGRGQC 1086
Query: 317 I--PERWRCDNERDCADGGDEL-NCKPNSIRNCSLDEYTCADRRC--VLKTWLCDGVRDC 371
+ P + C + G + NC I C D C C ++ C+ C
Sbjct: 1087 VNTPGDFECKCDEGYESGFMMMKNCM--DIDECQRDPLLCRGGVCHNTEGSYRCE----C 1140
Query: 372 TNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNR--KHVCDGMKDCPRGDDEERCPL 429
G +++ +S D C HL N CVN K+ C D C
Sbjct: 1141 PPGH-QLSPNISACIDINECELSAHLCPNG--RCVNLIGKYQCACNPGYHSTPDRLFCVD 1197
Query: 430 KRKCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VC-SQTC 486
+CS CE C T +G C+C GF L D+ SC DIDEC E +P +C C
Sbjct: 1198 IDECSIMNGGCETFC-TNSEGSYECSCQPGFALMPDQRSCTDIDEC--EDNPNICDGGQC 1254
Query: 487 SNTVGSFRCGCMTGYILRPDERSCKPTGE 515
+N G +RC C G++ D ++C E
Sbjct: 1255 TNIPGEYRCLCYDGFMASEDMKTCVDVNE 1283
Score = 74.9 bits (176), Expect = 2e-12
Identities = 63/218 (28%), Positives = 88/218 (40%), Gaps = 23/218 (10%)
Query: 304 CNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLK-- 361
C + C +G+CIP C E + G +L+ + I ++ CA C+
Sbjct: 453 CQLVRYLCQNGRCIPTPGSCRCE---CNKGFQLDLRGECIDVDECEKNPCAGGECINNQG 509
Query: 362 TWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRK---H-VCDGMKD 417
++ C C G C D C + +N C+N H VC+
Sbjct: 510 SYTCQ----CRAGYQSTLTRTECR-DIDECLQNGRICNNG--RCINTDGSFHCVCNAGFH 562
Query: 418 CPRGDDEERCPLKRKCSAEEKC-EKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMY 476
R D + C +CS C +CI DG C C GF LA D C+DI+EC
Sbjct: 563 VTR--DGKNCEDMDECSIRNMCLNGMCINE-DGSFKCICKPGFQLASDGRYCKDINEC-- 617
Query: 477 EQDPVC-SQTCSNTVGSFRCGCMTGYILRPDERSCKPT 513
E +C + C NT GS+RC C G + D R C T
Sbjct: 618 ETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDT 655
Score = 63.7 bits (148), Expect = 6e-09
Identities = 71/269 (26%), Positives = 101/269 (37%), Gaps = 47/269 (17%)
Query: 270 CKNTKCV--PKDFQCDGDN--DCG-----DWTDEDSCPMVPGSCNAGEFKCNDG----KC 316
C +CV P DF+C D + G + D D C P C G +G +C
Sbjct: 1081 CGRGQCVNTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCEC 1140
Query: 317 IPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCV--LKTWLCDGVRDCTNG 374
P N C D I C L + C + RCV + + C +
Sbjct: 1141 PPGHQLSPNISACID-----------INECELSAHLCPNGRCVNLIGKYQCACNPGYHST 1189
Query: 375 EDEMNCEVSCEEDQYTCRPQEHLMSNAFRN-CVNRKHVCDGMKDCPRGDDEERCPLKRKC 433
D + C V +E C +M+ C N +G +C P +R C
Sbjct: 1190 PDRLFC-VDIDE----CS----IMNGGCETFCTNS----EGSYECSCQPGFALMPDQRSC 1236
Query: 434 SAEEKCE---KLC----ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTC 486
+ ++CE +C T G C C GF+ +ED +C D++EC + S TC
Sbjct: 1237 TDIDECEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTC 1296
Query: 487 SNTVGSFRCGCMTGYILRPDERSCKPTGE 515
NT GSF C C GY + + C E
Sbjct: 1297 ENTKGSFICHCDMGYSGKKGKTGCTDINE 1325
Score = 60.5 bits (140), Expect = 5e-08
Identities = 55/214 (25%), Positives = 83/214 (38%), Gaps = 16/214 (7%)
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSC----EEDQYTCRPQEHLMSNA 401
C L Y C + RC+ C +C G +++ C E ++ C E + +
Sbjct: 453 CQLVRYLCQNGRCIPTPGSCRC--ECNKGF-QLDLRGECIDVDECEKNPCAGGECINNQG 509
Query: 402 FRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLL 461
C R + D +E R C+ CI T DG C C GF +
Sbjct: 510 SYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGR-----CINT-DGSFHCVCNAGFHV 563
Query: 462 AEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTG--ESPTL 519
D +C D+DEC ++ + C N GSF+C C G+ L D R CK E+P +
Sbjct: 564 TRDGKNCEDMDECSI-RNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPGI 622
Query: 520 LFSNRIGIRQVWLTGDNYMSVVKGLHNAVALDYH 553
+ R + + + GL V +D H
Sbjct: 623 CMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTH 656
Score = 60.1 bits (139), Expect = 7e-08
Identities = 68/264 (25%), Positives = 104/264 (39%), Gaps = 37/264 (14%)
Query: 260 LMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPG-SCNAGEFKCND-GKCI 317
+ C +ID EC+ + + C N G + E CP PG + C D +C
Sbjct: 1108 MKNCMDID-ECQRDPLLCRGGVCH--NTEGSYRCE--CP--PGHQLSPNISACIDINECE 1160
Query: 318 PERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGED 376
C N R C + + C N + + D C D C + C+ CTN E
Sbjct: 1161 LSAHLCPNGR-CVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGCETF--CTNSEG 1217
Query: 377 EMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPL------- 429
C SC+ + P + ++ C + ++CDG + C E RC
Sbjct: 1218 SYEC--SCQPG-FALMPDQRSCTD-IDECEDNPNICDGGQ-CTNIPGEYRCLCYDGFMAS 1272
Query: 430 --KRKCSAEEKCE---KLCIT----TYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP 480
+ C +C+ +C++ G C C MG+ + K C DI+EC
Sbjct: 1273 EDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHN 1332
Query: 481 VCSQ--TCSNTVGSFRCGCMTGYI 502
C + C+NT GSF+C C G+I
Sbjct: 1333 -CGKHAVCTNTAGSFKCSCSPGWI 1355
Score = 56.4 bits (130), Expect = 9e-07
Identities = 26/65 (40%), Positives = 32/65 (49%), Gaps = 2/65 (3%)
Query: 449 GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDER 508
G C CP GF+ D +C DIDEC E P + C N+ GSF C C + L P +
Sbjct: 786 GSFVCTCPKGFIYKPDLKTCEDIDEC--ESSPCINGVCKNSPGSFICECSSESTLDPTKT 843
Query: 509 SCKPT 513
C T
Sbjct: 844 ICIET 848
Score = 53.6 bits (123), Expect = 6e-06
Identities = 27/68 (39%), Positives = 30/68 (44%), Gaps = 1/68 (1%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
CI T G C CP G L E C DIDEC C+NTV S+ C C G+
Sbjct: 262 CINTV-GSFECKCPAGHKLNEVSQKCEDIDECSTIPGICEGGECTNTVSSYFCKCPPGFY 320
Query: 503 LRPDERSC 510
PD C
Sbjct: 321 TSPDGTRC 328
Score = 53.2 bits (122), Expect = 8e-06
Identities = 30/95 (31%), Positives = 41/95 (43%), Gaps = 5/95 (5%)
Query: 421 GDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP 480
G D C L CE L G C C G+ + +C DI+EC+
Sbjct: 721 GSDINECALDPDICPNGICENL-----RGTYKCICNSGYEVDSTGKNCVDINECVLNSLL 775
Query: 481 VCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
+ C NT GSF C C G+I +PD ++C+ E
Sbjct: 776 CDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDE 810
Score = 46.4 bits (105), Expect = 0.001
Identities = 22/65 (33%), Positives = 30/65 (46%)
Query: 455 CPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTG 514
C GF+ +C+D+DEC C NTVGSF C C G+ L + C+
Sbjct: 231 CRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKCEDID 290
Query: 515 ESPTL 519
E T+
Sbjct: 291 ECSTI 295
Score = 44.8 bits (101), Expect = 0.003
Identities = 27/83 (32%), Positives = 39/83 (46%), Gaps = 4/83 (4%)
Query: 437 EKCEKLCI-TTYDGHAACACPMGFLLAE---DKYSCRDIDECMYEQDPVCSQTCSNTVGS 492
E+CE+ + T + C GF E K +DI+EC C NT+GS
Sbjct: 991 EECEECPMRNTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPSLCTHGKCRNTIGS 1050
Query: 493 FRCGCMTGYILRPDERSCKPTGE 515
F+C C +G+ L +ER+C E
Sbjct: 1051 FKCRCDSGFALDSEERNCTDIDE 1073
Score = 38.3 bits (85), Expect = 0.25
Identities = 18/43 (41%), Positives = 21/43 (48%)
Query: 468 CRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSC 510
C DIDEC + C NT GSF+C C +G L R C
Sbjct: 908 CEDIDECEVFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRIC 950
Score = 36.3 bits (80), Expect = 1.00
Identities = 18/48 (37%), Positives = 24/48 (50%), Gaps = 5/48 (10%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTG---MPFEKSTTDQTPKKCKSHP 1366
C NGGC C S Y C+C G MP ++S TD +C+ +P
Sbjct: 1201 CSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTD--IDECEDNP 1246
Score = 36.3 bits (80), Expect = 1.00
Identities = 14/38 (36%), Positives = 17/38 (44%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NGGC C G C+C G L D ++C D
Sbjct: 1201 CSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTD 1238
>U69263-1|AAC51260.2| 956|Homo sapiens matrilin-2 precursor
protein.
Length = 956
Score = 77.4 bits (182), Expect = 4e-13
Identities = 51/171 (29%), Positives = 76/171 (44%), Gaps = 16/171 (9%)
Query: 346 CSLDEYTCADRRCVL--KTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFR 403
CS E+ CA C+ +++C + D+ C + Q C ++H N +
Sbjct: 242 CSTLEHNCA-HFCINIPGSYVCRCKQGYILNSDQTTCRI-----QDLCAMEDH---NCEQ 292
Query: 404 NCVN--RKHVCDGMKDCPRGDDEERCPLKRKCSAEEK-CEKLCITTYDGHAACACPMGFL 460
CVN VC +D +RC C++E CE C+ DG C C GF
Sbjct: 293 LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNA-DGSYLCQCHEGFA 351
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCK 511
L DK +C ID C + C C NT S+ C C+ G+ L PD+++C+
Sbjct: 352 LNPDKKTCTKIDYCA-SSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCR 401
Score = 70.9 bits (166), Expect = 4e-11
Identities = 64/263 (24%), Positives = 104/263 (39%), Gaps = 27/263 (10%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPG-SCNAGEFKCND-GKCIPE 319
RC +D+ C ++ C+ ++C + C G + N + C C
Sbjct: 317 RCVAVDY------CASENHGCE--HECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASS 368
Query: 320 RWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEM 378
C +E C + D +C + D+ TC C L C+ +C N E+
Sbjct: 369 NHGCQHE--CVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCE--HECVNMEESY 424
Query: 379 NCEV----SCEEDQYTCRPQEHLMSNAF---RNCVNRKH--VCDGMKDCPRGDDEERCPL 429
C + + + TC +H + C+N + VC + +D + C
Sbjct: 425 YCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSR 484
Query: 430 KRKCS-AEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSN 488
C ++ CE C+ D AC CP G +L D +C +D C D C +C +
Sbjct: 485 VDYCLLSDHGCEYSCVNM-DRSFACQCPEGHVLRSDGKTCAKLDSCALG-DHGCEHSCVS 542
Query: 489 TVGSFRCGCMTGYILRPDERSCK 511
+ SF C C GYILR D ++C+
Sbjct: 543 SEDSFVCQCFEGYILREDGKTCR 565
Score = 69.3 bits (162), Expect = 1e-10
Identities = 68/237 (28%), Positives = 96/237 (40%), Gaps = 39/237 (16%)
Query: 310 KCNDGKCI-PERWRCDNERDCA--DGGDE---LNCKPNSIRNCSLDEYTCADRRCVLKTW 363
+C+ G + P C CA D G E LN + + + CS D LKT
Sbjct: 427 RCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINED----LKT- 481
Query: 364 LCDGVRDCTNGEDEMNCEVSCE--EDQYTCR-PQEHLMSNAFRNCVNR----------KH 410
C V C + CE SC + + C+ P+ H++ + + C +H
Sbjct: 482 -CSRVDYCLLSDH--GCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEH 538
Query: 411 VCDGMKD-----CPRG----DDEERCPLKRKCSA-EEKCEKLCITTYDGHAACACPMGFL 460
C +D C G +D + C K C A + CE +C+ + D + C C +GF
Sbjct: 539 SCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYT-CECLVGFR 597
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESP 517
LAED CR D C C C N S+ C C G++L D R CK E P
Sbjct: 598 LAEDGKRCRRKDVCKSTHHG-CEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGP 653
Score = 39.9 bits (89), Expect = 0.081
Identities = 16/36 (44%), Positives = 17/36 (47%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C N GC H C+ G C C G LN D KTC
Sbjct: 324 CASENHGCEHECVNADGSYLCQCHEGFALNPDKKTC 359
Score = 39.9 bits (89), Expect = 0.081
Identities = 22/57 (38%), Positives = 25/57 (43%), Gaps = 2/57 (3%)
Query: 1005 AANKDTGAKRRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINY 1061
A N D + C +N GC H C+ SC C G LN D KTC INY
Sbjct: 351 ALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCR--RINY 405
Score = 38.7 bits (86), Expect = 0.19
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 1014 RRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
RR C + GC H+C+ +C C +G +L +DGK C
Sbjct: 565 RRKDVCQAIDHGCEHICVNSDDSYTCECLVGFRLAEDGKRC 605
Score = 38.7 bits (86), Expect = 0.19
Identities = 20/54 (37%), Positives = 27/54 (50%), Gaps = 4/54 (7%)
Query: 1014 RRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDG---KTCADGPINYLIF 1064
RR C + GC H+C+ C C G L +DG K C +GPI+ L+F
Sbjct: 606 RRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPID-LVF 658
Score = 38.3 bits (85), Expect = 0.25
Identities = 18/49 (36%), Positives = 22/49 (44%)
Query: 1007 NKDTGAKRRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCA 1055
N D RR C N GC H C+ C C G L+ +GKTC+
Sbjct: 394 NPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCS 442
Score = 37.9 bits (84), Expect = 0.33
Identities = 18/49 (36%), Positives = 24/49 (48%)
Query: 1007 NKDTGAKRRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCA 1055
N+D R C ++ GC + C+ +C CP G L DGKTCA
Sbjct: 476 NEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCA 524
Score = 37.1 bits (82), Expect = 0.57
Identities = 11/25 (44%), Positives = 17/25 (68%)
Query: 1631 CKESNGGCSHLCLFRGHEYICACPD 1655
CK ++ GC H+C+ G+ YIC C +
Sbjct: 611 CKSTHHGCEHICVNNGNSYICKCSE 635
Score = 36.7 bits (81), Expect = 0.76
Identities = 18/59 (30%), Positives = 30/59 (50%), Gaps = 3/59 (5%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINY-LIFAHRVDIRVISLD 1076
C + + GC LCL C C G +N+D KTC+ ++Y L+ H + +++D
Sbjct: 447 CAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCS--RVDYCLLSDHGCEYSCVNMD 503
Score = 36.7 bits (81), Expect = 0.76
Identities = 18/59 (30%), Positives = 29/59 (49%), Gaps = 3/59 (5%)
Query: 1319 ENACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGS 1377
++ C + + GC H+C+ + Y C C G F + + KKC P + L+F GS
Sbjct: 608 KDVCKSTHHGCEHICVNNGNSYICKCSEG--FVLAEDGRRCKKCTEGPID-LVFVIDGS 663
Score = 35.1 bits (77), Expect = 2.3
Identities = 14/36 (38%), Positives = 16/36 (44%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C C+H C+ PG C C G LN D TC
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTC 277
Score = 35.1 bits (77), Expect = 2.3
Identities = 14/36 (38%), Positives = 17/36 (47%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C + C LC+ PG C C G L +DGK C
Sbjct: 283 CAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRC 318
Score = 34.7 bits (76), Expect = 3.1
Identities = 14/36 (38%), Positives = 17/36 (47%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C + GC H C+ C C G L +DGKTC
Sbjct: 529 CALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTC 564
>AK075489-1|BAC11648.1| 451|Homo sapiens rase 7. protein.
Length = 451
Score = 77.4 bits (182), Expect = 4e-13
Identities = 51/171 (29%), Positives = 76/171 (44%), Gaps = 16/171 (9%)
Query: 346 CSLDEYTCADRRCVL--KTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFR 403
CS E+ CA C+ +++C + D+ C + Q C ++H N +
Sbjct: 242 CSTLEHNCA-HFCINIPGSYVCRCKQGYILNSDQTTCRI-----QDLCAMEDH---NCEQ 292
Query: 404 NCVN--RKHVCDGMKDCPRGDDEERCPLKRKCSAEEK-CEKLCITTYDGHAACACPMGFL 460
CVN VC +D +RC C++E CE C+ DG C C GF
Sbjct: 293 LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNA-DGSYLCQCHEGFA 351
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCK 511
L DK +C ID C + C C NT S+ C C+ G+ L PD+++C+
Sbjct: 352 LNPDKKTCTKIDYCA-SSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCR 401
Score = 70.9 bits (166), Expect = 4e-11
Identities = 51/199 (25%), Positives = 87/199 (43%), Gaps = 18/199 (9%)
Query: 317 IPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLK--TWLCDGVRDCTNG 374
IP + C ++ D+ C+ + C+++++ C ++ CV +++C
Sbjct: 256 IPGSYVCRCKQGYILNSDQTTCRIQDL--CAMEDHNC-EQLCVNVPGSFVCQCYSGYALA 312
Query: 375 EDEMNCEVS--CEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRK 432
ED C C + + C EH NA + ++C + D++ C
Sbjct: 313 EDGKRCVAVDYCASENHGC---EHECVNA-----DGSYLCQCHEGFALNPDKKTCTKIDY 364
Query: 433 C-SAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVG 491
C S+ C+ C+ T D ++ C C GF L DK +CR I+ C + P C C N
Sbjct: 365 CASSNHGCQHECVNTDDSYS-CHCLKGFTLNPDKKTCRRINYCALNK-PGCEHECVNMEE 422
Query: 492 SFRCGCMTGYILRPDERSC 510
S+ C C GY L P+ ++C
Sbjct: 423 SYYCRCHRGYTLDPNGKTC 441
Score = 39.9 bits (89), Expect = 0.081
Identities = 16/36 (44%), Positives = 17/36 (47%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C N GC H C+ G C C G LN D KTC
Sbjct: 324 CASENHGCEHECVNADGSYLCQCHEGFALNPDKKTC 359
Score = 39.9 bits (89), Expect = 0.081
Identities = 22/57 (38%), Positives = 25/57 (43%), Gaps = 2/57 (3%)
Query: 1005 AANKDTGAKRRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINY 1061
A N D + C +N GC H C+ SC C G LN D KTC INY
Sbjct: 351 ALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCR--RINY 405
Score = 38.3 bits (85), Expect = 0.25
Identities = 18/49 (36%), Positives = 22/49 (44%)
Query: 1007 NKDTGAKRRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCA 1055
N D RR C N GC H C+ C C G L+ +GKTC+
Sbjct: 394 NPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCS 442
Score = 35.1 bits (77), Expect = 2.3
Identities = 14/36 (38%), Positives = 16/36 (44%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C C+H C+ PG C C G LN D TC
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTC 277
Score = 35.1 bits (77), Expect = 2.3
Identities = 14/36 (38%), Positives = 17/36 (47%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C + C LC+ PG C C G L +DGK C
Sbjct: 283 CAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRC 318
>X82494-1|CAA57876.1| 1184|Homo sapiens fibulin-2 protein.
Length = 1184
Score = 76.6 bits (180), Expect = 8e-13
Identities = 77/291 (26%), Positives = 112/291 (38%), Gaps = 48/291 (16%)
Query: 268 FEC-KNTKCVP----KDFQCDGDNDC--GDWTDEDS--CPMVPGS--CNAGEFKCNDGKC 316
F C K C P KD +C+ ++C G T + C GS C A + +C DG
Sbjct: 743 FHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQ-RCMDGFL 801
Query: 317 IPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWL--------CDGV 368
C + +C + C+P ++ YTC + C V
Sbjct: 802 QDPEGNCVDINECTSLSEP--CRPGFSCINTVGSYTCQRNPLICARGYHASDDGAKCVDV 859
Query: 369 RDCTNGEDEMNCEVSCEE--DQYTCRPQEHLMSNAF-RNCVNR-----------KHVCDG 414
+C G C Y C + +AF R C++ +H C+
Sbjct: 860 NECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCEN 919
Query: 415 MK-----DCPRG----DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDK 465
C G D +RC +C A+ +C + C Y G C C G+ LAED
Sbjct: 920 TLGSYRCSCASGFLLAADGKRCEDVNECEAQ-RCSQECANIY-GSYQCYCRQGYQLAEDG 977
Query: 466 YSCRDIDECMYEQDPVCSQTCSNTVGSFRCGC-MTGYILRPDERSCKPTGE 515
++C DIDEC +C+ C N GS++C C GY + + RSCK E
Sbjct: 978 HTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDE 1028
Score = 72.1 bits (169), Expect = 2e-11
Identities = 60/243 (24%), Positives = 95/243 (39%), Gaps = 22/243 (9%)
Query: 282 CDGDNDCGDWTDEDSCPMVPGSCNA-GEFKCNDG-KCIP----ERWRCDNERDCADGGDE 335
C+ N+C TD +C N G F C C P + C++ +CA G
Sbjct: 717 CEDINECV--TDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTH- 773
Query: 336 LNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQE 395
C+P + + + C R+ + +L D +C ++N C CRP
Sbjct: 774 -TCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCV----DIN---ECTSLSEPCRPGF 825
Query: 396 HLMSNAFR-NCVNRKHVCDGMKDCPRGDDEERCPLKRKC-SAEEKC-EKLCITTYDGHAA 452
++ C +C + DD +C +C + +C E G
Sbjct: 826 SCINTVGSYTCQRNPLIC--ARGYHASDDGAKCVDVNECETGVHRCGEGQVCHNLPGSYR 883
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP 512
C C GF C D++EC +C TC NT+GS+RC C +G++L D + C+
Sbjct: 884 CDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCED 943
Query: 513 TGE 515
E
Sbjct: 944 VNE 946
Score = 58.0 bits (134), Expect = 3e-07
Identities = 58/254 (22%), Positives = 100/254 (39%), Gaps = 13/254 (5%)
Query: 273 TKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIP--ERWRCDNER--D 328
T+ VP+ Q + + TD +S +P S G K C ++W DN+ +
Sbjct: 402 TREVPRKPQVLPHSHVEEDTDPNSVHSIPRSSPEGSTKDLIETCCAAGQQWAIDNDECLE 461
Query: 329 CADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQ 388
+ G E N + R+C + ++ C+ C ED +C +S +
Sbjct: 462 IPESGTEDNVCRTAQRHCCVSYLQ--EKSCMAGVLGAKEGETC-GAEDNDSCGISLYKQC 518
Query: 389 YTCRPQEHLMSNAFRNCVNRKHV---CDG-MKDCPRGDDEERCP-LKRKCSAEEKCEKLC 443
C + ++C + ++ C+ M C G++ P ++R ++
Sbjct: 519 CDCCGLGLRVRAEGQSCESNPNLGYPCNHVMLSCCEGEEPLIVPEVRRPPEPAAAPRRVS 578
Query: 444 ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYIL 503
G A + L + D DEC+ +C C NTVGS+ C C G+ L
Sbjct: 579 EAEMAGREALSLGTEAELP-NSLPGDDQDECLLLPGELCQHLCINTVGSYHCACFPGFSL 637
Query: 504 RPDERSCKPTGESP 517
+ D R+C+P G P
Sbjct: 638 QDDGRTCRPEGHPP 651
Score = 56.4 bits (130), Expect = 9e-07
Identities = 31/86 (36%), Positives = 44/86 (51%), Gaps = 8/86 (9%)
Query: 428 PLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCS--QT 485
P C C+++C +T G A C+C G+ + D SC DI+EC+ + CS +
Sbjct: 678 PQPNTCKDNGPCKQVC-STVGGSAICSCFPGYAIMADGVSCEDINECVTDLH-TCSRGEH 735
Query: 486 CSNTVGSFRC----GCMTGYILRPDE 507
C NT+GSF C C GY L+ E
Sbjct: 736 CVNTLGSFHCYKALTCEPGYALKDGE 761
Score = 51.2 bits (117), Expect = 3e-05
Identities = 76/303 (25%), Positives = 106/303 (34%), Gaps = 41/303 (13%)
Query: 213 IGDVITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKN 272
+G P L TK + + C L + N+ L F C N
Sbjct: 770 MGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCIN 829
Query: 273 T----KCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK-C--IPERWRCDN 325
T C C D D C V C G +C +G+ C +P +RCD
Sbjct: 830 TVGSYTCQRNPLICARGYHASD--DGAKCVDV-NECETGVHRCGEGQVCHNLPGSYRCDC 886
Query: 326 ----ERDCADGG--DELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMN 379
+RD G D C + R C ++TC + L ++ C D
Sbjct: 887 KAGFQRDAFGRGCIDVNECWASPGRLC---QHTCEN---TLGSYRCSCASGFLLAADGKR 940
Query: 380 CEVSCEEDQYTCRPQEHLMSNAFRNCVN--RKHVCDGMKDCPRGDDEERCPLKRKCS--A 435
CE D C Q + C N + C + +D C +C+ A
Sbjct: 941 CE-----DVNECEAQR-----CSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGA 990
Query: 436 EEKCEKLCITTYDGHAACACP-MGFLLAEDKYSCRDIDECMYEQDPVCS--QTCSNTVGS 492
C C+ G CACP G+ + + SC+D+DEC CS +TC N GS
Sbjct: 991 GILCTFRCLNV-PGSYQCACPEQGYTMTANGRSCKDVDECALGTHN-CSEAETCHNIQGS 1048
Query: 493 FRC 495
FRC
Sbjct: 1049 FRC 1051
Score = 36.7 bits (81), Expect = 0.76
Identities = 14/29 (48%), Positives = 16/29 (55%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C HLC+ G CAC G L DG+TC
Sbjct: 616 CQHLCINTVGSYHCACFPGFSLQDDGRTC 644
Score = 35.5 bits (78), Expect = 1.7
Identities = 15/37 (40%), Positives = 17/37 (45%)
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPT 518
C Q CS GS C C GY + D SC+ E T
Sbjct: 689 CKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECVT 725
>BC051690-1|AAH51690.1| 1184|Homo sapiens fibulin 2 protein.
Length = 1184
Score = 76.6 bits (180), Expect = 8e-13
Identities = 77/291 (26%), Positives = 112/291 (38%), Gaps = 48/291 (16%)
Query: 268 FEC-KNTKCVP----KDFQCDGDNDC--GDWTDEDS--CPMVPGS--CNAGEFKCNDGKC 316
F C K C P KD +C+ ++C G T + C GS C A + +C DG
Sbjct: 743 FHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQ-RCMDGFL 801
Query: 317 IPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWL--------CDGV 368
C + +C + C+P ++ YTC + C V
Sbjct: 802 QDPEGNCVDINECTSLSEP--CRPGFSCINTVGSYTCQRNPLICARGYHASDDGAKCVDV 859
Query: 369 RDCTNGEDEMNCEVSCEE--DQYTCRPQEHLMSNAF-RNCVNR-----------KHVCDG 414
+C G C Y C + +AF R C++ +H C+
Sbjct: 860 NECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCEN 919
Query: 415 MK-----DCPRG----DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDK 465
C G D +RC +C A+ +C + C Y G C C G+ LAED
Sbjct: 920 TLGSYRCSCASGFLLAADGKRCEDVNECEAQ-RCSQECANIY-GSYQCYCRQGYQLAEDG 977
Query: 466 YSCRDIDECMYEQDPVCSQTCSNTVGSFRCGC-MTGYILRPDERSCKPTGE 515
++C DIDEC +C+ C N GS++C C GY + + RSCK E
Sbjct: 978 HTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDE 1028
Score = 72.1 bits (169), Expect = 2e-11
Identities = 60/243 (24%), Positives = 95/243 (39%), Gaps = 22/243 (9%)
Query: 282 CDGDNDCGDWTDEDSCPMVPGSCNA-GEFKCNDG-KCIP----ERWRCDNERDCADGGDE 335
C+ N+C TD +C N G F C C P + C++ +CA G
Sbjct: 717 CEDINECV--TDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTH- 773
Query: 336 LNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQE 395
C+P + + + C R+ + +L D +C ++N C CRP
Sbjct: 774 -TCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCV----DIN---ECTSLSEPCRPGF 825
Query: 396 HLMSNAFR-NCVNRKHVCDGMKDCPRGDDEERCPLKRKC-SAEEKC-EKLCITTYDGHAA 452
++ C +C + DD +C +C + +C E G
Sbjct: 826 SCINTVGSYTCQRNPLIC--ARGYHASDDGAKCVDVNECETGVHRCGEGQVCHNLPGSYR 883
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP 512
C C GF C D++EC +C TC NT+GS+RC C +G++L D + C+
Sbjct: 884 CDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCED 943
Query: 513 TGE 515
E
Sbjct: 944 VNE 946
Score = 58.0 bits (134), Expect = 3e-07
Identities = 58/254 (22%), Positives = 100/254 (39%), Gaps = 13/254 (5%)
Query: 273 TKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIP--ERWRCDNER--D 328
T+ VP+ Q + + TD +S +P S G K C ++W DN+ +
Sbjct: 402 TREVPRKPQVLPHSHVEEDTDPNSVHSIPRSSPEGSTKDLIETCCAAGQQWAIDNDECLE 461
Query: 329 CADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQ 388
+ G E N + R+C + ++ C+ C ED +C +S +
Sbjct: 462 IPESGTEDNVCRTAQRHCCVSYLQ--EKSCMAGVLGAKEGETC-GAEDNDSCGISLYKQC 518
Query: 389 YTCRPQEHLMSNAFRNCVNRKHV---CDG-MKDCPRGDDEERCP-LKRKCSAEEKCEKLC 443
C + ++C + ++ C+ M C G++ P ++R ++
Sbjct: 519 CDCCGLGLRVRAEGQSCESNPNLGYPCNHVMLSCCEGEEPLIVPEVRRPPEPAAAPRRVS 578
Query: 444 ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYIL 503
G A + L + D DEC+ +C C NTVGS+ C C G+ L
Sbjct: 579 EAEMAGREALSLGTEAELP-NSLPGDDQDECLLLPGELCQHLCINTVGSYHCACFPGFSL 637
Query: 504 RPDERSCKPTGESP 517
+ D R+C+P G P
Sbjct: 638 QDDGRTCRPEGHPP 651
Score = 56.4 bits (130), Expect = 9e-07
Identities = 31/86 (36%), Positives = 44/86 (51%), Gaps = 8/86 (9%)
Query: 428 PLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCS--QT 485
P C C+++C +T G A C+C G+ + D SC DI+EC+ + CS +
Sbjct: 678 PQPNTCKDNGPCKQVC-STVGGSAICSCFPGYAIMADGVSCEDINECVTDLH-TCSRGEH 735
Query: 486 CSNTVGSFRC----GCMTGYILRPDE 507
C NT+GSF C C GY L+ E
Sbjct: 736 CVNTLGSFHCYKALTCEPGYALKDGE 761
Score = 51.2 bits (117), Expect = 3e-05
Identities = 76/303 (25%), Positives = 106/303 (34%), Gaps = 41/303 (13%)
Query: 213 IGDVITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKN 272
+G P L TK + + C L + N+ L F C N
Sbjct: 770 MGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCIN 829
Query: 273 T----KCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK-C--IPERWRCDN 325
T C C D D C V C G +C +G+ C +P +RCD
Sbjct: 830 TVGSYTCQRNPLICARGYHASD--DGAKCVDV-NECETGVHRCGEGQVCHNLPGSYRCDC 886
Query: 326 ----ERDCADGG--DELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMN 379
+RD G D C + R C ++TC + L ++ C D
Sbjct: 887 KAGFQRDAFGRGCIDVNECWASPGRLC---QHTCEN---TLGSYRCSCASGFLLAADGKR 940
Query: 380 CEVSCEEDQYTCRPQEHLMSNAFRNCVN--RKHVCDGMKDCPRGDDEERCPLKRKCS--A 435
CE D C Q + C N + C + +D C +C+ A
Sbjct: 941 CE-----DVNECEAQR-----CSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGA 990
Query: 436 EEKCEKLCITTYDGHAACACP-MGFLLAEDKYSCRDIDECMYEQDPVCS--QTCSNTVGS 492
C C+ G CACP G+ + + SC+D+DEC CS +TC N GS
Sbjct: 991 GILCTFRCLNV-PGSYQCACPEQGYTMTANGRSCKDVDECALGTHN-CSEAETCHNIQGS 1048
Query: 493 FRC 495
FRC
Sbjct: 1049 FRC 1051
Score = 36.7 bits (81), Expect = 0.76
Identities = 14/29 (48%), Positives = 16/29 (55%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C HLC+ G CAC G L DG+TC
Sbjct: 616 CQHLCINTVGSYHCACFPGFSLQDDGRTC 644
Score = 35.5 bits (78), Expect = 1.7
Identities = 15/37 (40%), Positives = 17/37 (45%)
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPT 518
C Q CS GS C C GY + D SC+ E T
Sbjct: 689 CKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECVT 725
>AY130459-1|AAN05436.1| 1231|Homo sapiens fibulin 2 protein.
Length = 1231
Score = 76.6 bits (180), Expect = 8e-13
Identities = 77/291 (26%), Positives = 112/291 (38%), Gaps = 48/291 (16%)
Query: 268 FEC-KNTKCVP----KDFQCDGDNDC--GDWTDEDS--CPMVPGS--CNAGEFKCNDGKC 316
F C K C P KD +C+ ++C G T + C GS C A + +C DG
Sbjct: 790 FHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQ-RCMDGFL 848
Query: 317 IPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWL--------CDGV 368
C + +C + C+P ++ YTC + C V
Sbjct: 849 QDPEGNCVDINECTSLSEP--CRPGFSCINTVGSYTCQRNPLICARGYHASDDGAKCVDV 906
Query: 369 RDCTNGEDEMNCEVSCEE--DQYTCRPQEHLMSNAF-RNCVNR-----------KHVCDG 414
+C G C Y C + +AF R C++ +H C+
Sbjct: 907 NECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCEN 966
Query: 415 MK-----DCPRG----DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDK 465
C G D +RC +C A+ +C + C Y G C C G+ LAED
Sbjct: 967 TLGSYRCSCASGFLLAADGKRCEDVNECEAQ-RCSQECANIY-GSYQCYCRQGYQLAEDG 1024
Query: 466 YSCRDIDECMYEQDPVCSQTCSNTVGSFRCGC-MTGYILRPDERSCKPTGE 515
++C DIDEC +C+ C N GS++C C GY + + RSCK E
Sbjct: 1025 HTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDE 1075
Score = 74.1 bits (174), Expect = 4e-12
Identities = 61/244 (25%), Positives = 96/244 (39%), Gaps = 22/244 (9%)
Query: 281 QCDGDNDCGDWTDEDSCPMVPGSCNA-GEFKCNDG-KCIP----ERWRCDNERDCADGGD 334
+C G N+C TD +C N G F C C P + C++ +CA G
Sbjct: 763 KCVGKNECV--TDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTH 820
Query: 335 ELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ 394
C+P + + + C R+ + +L D +C ++N C CRP
Sbjct: 821 --TCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCV----DIN---ECTSLSEPCRPG 871
Query: 395 EHLMSNAFR-NCVNRKHVCDGMKDCPRGDDEERCPLKRKC-SAEEKC-EKLCITTYDGHA 451
++ C +C + DD +C +C + +C E G
Sbjct: 872 FSCINTVGSYTCQRNPLIC--ARGYHASDDGAKCVDVNECETGVHRCGEGQVCHNLPGSY 929
Query: 452 ACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCK 511
C C GF C D++EC +C TC NT+GS+RC C +G++L D + C+
Sbjct: 930 RCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCE 989
Query: 512 PTGE 515
E
Sbjct: 990 DVNE 993
Score = 58.0 bits (134), Expect = 3e-07
Identities = 58/254 (22%), Positives = 100/254 (39%), Gaps = 13/254 (5%)
Query: 273 TKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIP--ERWRCDNER--D 328
T+ VP+ Q + + TD +S +P S G K C ++W DN+ +
Sbjct: 402 TREVPRKPQVLPHSHVEEDTDPNSVHSIPRSSPEGSTKDLIETCCAAGQQWAIDNDECLE 461
Query: 329 CADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQ 388
+ G E N + R+C + ++ C+ C ED +C +S +
Sbjct: 462 IPESGTEDNVCRTAQRHCCVSYLQ--EKSCMAGVLGAKEGETC-GAEDNDSCGISLYKQC 518
Query: 389 YTCRPQEHLMSNAFRNCVNRKHV---CDG-MKDCPRGDDEERCP-LKRKCSAEEKCEKLC 443
C + ++C + ++ C+ M C G++ P ++R ++
Sbjct: 519 CDCCGLGLRVRAEGQSCESNPNLGYPCNHVMLSCCEGEEPLIVPEVRRPPEPAAAPRRVS 578
Query: 444 ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYIL 503
G A + L + D DEC+ +C C NTVGS+ C C G+ L
Sbjct: 579 EAEMAGREALSLGTEAELP-NSLPGDDQDECLLLPGELCQHLCINTVGSYHCACFPGFSL 637
Query: 504 RPDERSCKPTGESP 517
+ D R+C+P G P
Sbjct: 638 QDDGRTCRPEGHPP 651
Score = 56.8 bits (131), Expect = 7e-07
Identities = 36/97 (37%), Positives = 44/97 (45%), Gaps = 8/97 (8%)
Query: 428 PLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC-MYEQDPVCSQTC 486
P C C+++C +T G A C+C G+ + D SC D DEC M D Q C
Sbjct: 678 PQPNTCKDNGPCKQVC-STVGGSAICSCFPGYAIMADGVSCEDQDECLMGAHDCSRRQFC 736
Query: 487 SNTVGSFRCG-----CMTGYILRPDERSCKPTGESPT 518
NT+GSF C C GYIL R C E T
Sbjct: 737 VNTLGSFYCVNHTVLCADGYILNA-HRKCVGKNECVT 772
Score = 51.2 bits (117), Expect = 3e-05
Identities = 76/303 (25%), Positives = 106/303 (34%), Gaps = 41/303 (13%)
Query: 213 IGDVITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKN 272
+G P L TK + + C L + N+ L F C N
Sbjct: 817 MGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCIN 876
Query: 273 T----KCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK-C--IPERWRCDN 325
T C C D D C V C G +C +G+ C +P +RCD
Sbjct: 877 TVGSYTCQRNPLICARGYHASD--DGAKCVDV-NECETGVHRCGEGQVCHNLPGSYRCDC 933
Query: 326 ----ERDCADGG--DELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMN 379
+RD G D C + R C ++TC + L ++ C D
Sbjct: 934 KAGFQRDAFGRGCIDVNECWASPGRLC---QHTCEN---TLGSYRCSCASGFLLAADGKR 987
Query: 380 CEVSCEEDQYTCRPQEHLMSNAFRNCVN--RKHVCDGMKDCPRGDDEERCPLKRKCS--A 435
CE D C Q + C N + C + +D C +C+ A
Sbjct: 988 CE-----DVNECEAQR-----CSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGA 1037
Query: 436 EEKCEKLCITTYDGHAACACP-MGFLLAEDKYSCRDIDECMYEQDPVCS--QTCSNTVGS 492
C C+ G CACP G+ + + SC+D+DEC CS +TC N GS
Sbjct: 1038 GILCTFRCLNV-PGSYQCACPEQGYTMTANGRSCKDVDECALGTHN-CSEAETCHNIQGS 1095
Query: 493 FRC 495
FRC
Sbjct: 1096 FRC 1098
Score = 36.7 bits (81), Expect = 0.76
Identities = 14/29 (48%), Positives = 16/29 (55%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C HLC+ G CAC G L DG+TC
Sbjct: 616 CQHLCINTVGSYHCACFPGFSLQDDGRTC 644
>AY130458-1|AAN05435.1| 1231|Homo sapiens fibulin 2 protein.
Length = 1231
Score = 76.6 bits (180), Expect = 8e-13
Identities = 77/291 (26%), Positives = 112/291 (38%), Gaps = 48/291 (16%)
Query: 268 FEC-KNTKCVP----KDFQCDGDNDC--GDWTDEDS--CPMVPGS--CNAGEFKCNDGKC 316
F C K C P KD +C+ ++C G T + C GS C A + +C DG
Sbjct: 790 FHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQ-RCMDGFL 848
Query: 317 IPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWL--------CDGV 368
C + +C + C+P ++ YTC + C V
Sbjct: 849 QDPEGNCVDINECTSLSEP--CRPGFSCINTVGSYTCQRNPLICARGYHASDDGXKCVDV 906
Query: 369 RDCTNGEDEMNCEVSCEE--DQYTCRPQEHLMSNAF-RNCVNR-----------KHVCDG 414
+C G C Y C + +AF R C++ +H C+
Sbjct: 907 NECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCEN 966
Query: 415 MK-----DCPRG----DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDK 465
C G D +RC +C A+ +C + C Y G C C G+ LAED
Sbjct: 967 TLGSYRCSCASGFLLAADGKRCEDVNECEAQ-RCSQECANIY-GSYQCYCRQGYQLAEDG 1024
Query: 466 YSCRDIDECMYEQDPVCSQTCSNTVGSFRCGC-MTGYILRPDERSCKPTGE 515
++C DIDEC +C+ C N GS++C C GY + + RSCK E
Sbjct: 1025 HTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDE 1075
Score = 70.5 bits (165), Expect = 5e-11
Identities = 60/244 (24%), Positives = 95/244 (38%), Gaps = 22/244 (9%)
Query: 281 QCDGDNDCGDWTDEDSCPMVPGSCNA-GEFKCNDG-KCIP----ERWRCDNERDCADGGD 334
+C N+C TD +C N G F C C P + C++ +CA G
Sbjct: 763 KCVDINECV--TDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTH 820
Query: 335 ELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ 394
C+P + + + C R+ + +L D +C ++N C CRP
Sbjct: 821 --TCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCV----DIN---ECTSLSEPCRPG 871
Query: 395 EHLMSNAFR-NCVNRKHVCDGMKDCPRGDDEERCPLKRKC-SAEEKC-EKLCITTYDGHA 451
++ C +C + DD +C +C + +C E G
Sbjct: 872 FSCINTVGSYTCQRNPLIC--ARGYHASDDGXKCVDVNECETGVHRCGEGQVCHNLPGSY 929
Query: 452 ACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCK 511
C C GF C D++EC +C TC NT+GS+RC C +G++L D + C+
Sbjct: 930 RCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCE 989
Query: 512 PTGE 515
E
Sbjct: 990 DVNE 993
Score = 58.0 bits (134), Expect = 3e-07
Identities = 58/254 (22%), Positives = 100/254 (39%), Gaps = 13/254 (5%)
Query: 273 TKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIP--ERWRCDNER--D 328
T+ VP+ Q + + TD +S +P S G K C ++W DN+ +
Sbjct: 402 TREVPRKPQVLPHSHVEEDTDPNSVHSIPRSSPEGSTKDLIETCCAAGQQWAIDNDECLE 461
Query: 329 CADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQ 388
+ G E N + R+C + ++ C+ C ED +C +S +
Sbjct: 462 IPESGTEDNVCRTAQRHCCVSYLQ--EKSCMAGVLGAKEGETC-GAEDNDSCGISLYKQC 518
Query: 389 YTCRPQEHLMSNAFRNCVNRKHV---CDG-MKDCPRGDDEERCP-LKRKCSAEEKCEKLC 443
C + ++C + ++ C+ M C G++ P ++R ++
Sbjct: 519 CDCCGLGLRVRAEGQSCESNPNLGYPCNHVMLSCCEGEEPLIVPEVRRPPEPAAAPRRVS 578
Query: 444 ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYIL 503
G A + L + D DEC+ +C C NTVGS+ C C G+ L
Sbjct: 579 EAEMAGREALSLGTEAELP-NSLPGDDQDECLLLPGELCQHLCINTVGSYHCACFPGFSL 637
Query: 504 RPDERSCKPTGESP 517
+ D R+C+P G P
Sbjct: 638 QDDGRTCRPEGHPP 651
Score = 57.2 bits (132), Expect = 5e-07
Identities = 36/97 (37%), Positives = 44/97 (45%), Gaps = 8/97 (8%)
Query: 428 PLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC-MYEQDPVCSQTC 486
P C C+++C +T G A C+C G+ + D SC D DEC M D Q C
Sbjct: 678 PQPNTCKDNGPCKQVC-STVGGSAICSCFPGYAIMADGVSCEDQDECLMGAHDCSRRQFC 736
Query: 487 SNTVGSFRCG-----CMTGYILRPDERSCKPTGESPT 518
NT+GSF C C GYIL R C E T
Sbjct: 737 VNTLGSFYCVNHTVLCADGYILNA-HRKCVDINECVT 772
Score = 51.6 bits (118), Expect = 2e-05
Identities = 76/303 (25%), Positives = 106/303 (34%), Gaps = 41/303 (13%)
Query: 213 IGDVITNPTVLIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKN 272
+G P L TK + + C L + N+ L F C N
Sbjct: 817 MGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCIN 876
Query: 273 T----KCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK-C--IPERWRCDN 325
T C C D D C V C G +C +G+ C +P +RCD
Sbjct: 877 TVGSYTCQRNPLICARGYHASD--DGXKCVDV-NECETGVHRCGEGQVCHNLPGSYRCDC 933
Query: 326 ----ERDCADGG--DELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMN 379
+RD G D C + R C ++TC + L ++ C D
Sbjct: 934 KAGFQRDAFGRGCIDVNECWASPGRLC---QHTCEN---TLGSYRCSCASGFLLAADGKR 987
Query: 380 CEVSCEEDQYTCRPQEHLMSNAFRNCVN--RKHVCDGMKDCPRGDDEERCPLKRKCS--A 435
CE D C Q + C N + C + +D C +C+ A
Sbjct: 988 CE-----DVNECEAQR-----CSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGA 1037
Query: 436 EEKCEKLCITTYDGHAACACP-MGFLLAEDKYSCRDIDECMYEQDPVCS--QTCSNTVGS 492
C C+ G CACP G+ + + SC+D+DEC CS +TC N GS
Sbjct: 1038 GILCTFRCLNV-PGSYQCACPEQGYTMTANGRSCKDVDECALGTHN-CSEAETCHNIQGS 1095
Query: 493 FRC 495
FRC
Sbjct: 1096 FRC 1098
Score = 36.7 bits (81), Expect = 0.76
Identities = 14/29 (48%), Positives = 16/29 (55%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C HLC+ G CAC G L DG+TC
Sbjct: 616 CQHLCINTVGSYHCACFPGFSLQDDGRTC 644
>Z98047-1|CAI19628.1| 703|Homo sapiens fibulin 1 protein.
Length = 703
Score = 75.8 bits (178), Expect = 1e-12
Identities = 60/243 (24%), Positives = 93/243 (38%), Gaps = 21/243 (8%)
Query: 282 CDGDNDCGDWTDEDSCPMVPGSCNA-GEFKCN-DGKC-----IPERWRCDNERDCADGGD 334
C+ N+C T SC + N G F+C D C + E C + +C G
Sbjct: 214 CEDVNEC--ITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIH 271
Query: 335 ELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ 394
NC P+ I +L + C + ++ D + +C + + ++ C +TC
Sbjct: 272 --NCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIG-HTCINT 328
Query: 395 E--HLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAA 452
E + NC H+ + C D +E P C +C G
Sbjct: 329 EGSYTCQKNVPNCGRGYHLNEEGTRCV--DVDECAPPAEPCGKGHRC-----VNSPGSFR 381
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP 512
C C G+ C D++EC +C C NT+GS+ C C G+ L D RSC+
Sbjct: 382 CECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCED 441
Query: 513 TGE 515
E
Sbjct: 442 INE 444
Score = 68.5 bits (160), Expect = 2e-10
Identities = 74/280 (26%), Positives = 102/280 (36%), Gaps = 32/280 (11%)
Query: 263 CAEIDFECKNT--KCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND-GKCIPE 319
C +ID EC++ C+P DF C N G + G C D +C+
Sbjct: 260 CKDID-ECESGIHNCLP-DFICQ--NTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSI 315
Query: 320 RWRCDNERDCADGGDELNCK---PNSIRNCSLDEY--TCAD-RRCVLKTWLCDGVRDCTN 373
C C + C+ PN R L+E C D C C C N
Sbjct: 316 SAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVN 375
Query: 374 GEDEMNCEVSCEEDQY------TCRPQEHLMSNAFRNCVNR------KHVCDGMKDCPRG 421
CE C+ Y C R C ++ ++C
Sbjct: 376 SPGSFRCE--CKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLS 433
Query: 422 DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAE-DKYSCRDIDECMYEQDP 480
D C +CS+ C + C Y G C C G+ L++ D +C DIDEC
Sbjct: 434 VDGRSCEDINECSSSP-CSQECANVY-GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGG 491
Query: 481 -VCSQTCSNTVGSFRCGC-MTGYILRPDERSCKPTGESPT 518
+CS C N GSF+C C +GY L P+ R+C+ E T
Sbjct: 492 HICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVT 531
Score = 67.7 bits (158), Expect = 4e-10
Identities = 70/262 (26%), Positives = 104/262 (39%), Gaps = 43/262 (16%)
Query: 280 FQCDGDNDCG---DWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDEL 336
F+C D+ CG + T+++SC + C +G C +P+ + C N +L
Sbjct: 240 FRCQRDSSCGTGYELTEDNSCKDID-ECESGIHNC-----LPD-FICQNTLGSFRCRPKL 292
Query: 337 NCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQE 395
CK I++ + C D C+ + C C N E +C+++ C
Sbjct: 293 QCKSGFIQDALGN---CIDINECLSISAPCPIGHTCINTEGSY----TCQKNVPNCGRGY 345
Query: 396 HLMSNAFR-----NCVNRKHVCDGMKDCPRGDDEERCPLK---------RKCSAEEKCEK 441
HL R C C C RC K R C +C++
Sbjct: 346 HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQR 405
Query: 442 ----LCITTYD---GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFR 494
LC + G C+C +GF L+ D SC DI+EC P CSQ C+N GS++
Sbjct: 406 YPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSSP-CSQECANVYGSYQ 462
Query: 495 CGCMTGYILRP-DERSCKPTGE 515
C C GY L D +C+ E
Sbjct: 463 CYCRRGYQLSDVDGVTCEDIDE 484
Score = 62.9 bits (146), Expect = 1e-08
Identities = 37/100 (37%), Positives = 51/100 (51%), Gaps = 8/100 (8%)
Query: 422 DDEERCP-LKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP 480
++E+ P L +C C++ C T D C+C +G+ L D SC D++EC+
Sbjct: 168 EEEQEDPYLNDRCRGGGPCKQQCRDTGD-EVVCSCFVGYQLLSDGVSCEDVNECITGSHS 226
Query: 481 V-CSQTCSNTVGSFRC----GCMTGYILRPDERSCKPTGE 515
++C NTVGSFRC C TGY L D SCK E
Sbjct: 227 CRLGESCINTVGSFRCQRDSSCGTGYELTED-NSCKDIDE 265
Score = 44.4 bits (100), Expect = 0.004
Identities = 50/207 (24%), Positives = 78/207 (37%), Gaps = 15/207 (7%)
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYT 352
D D C C G +C + P +RC+ + G C + C
Sbjct: 356 DVDECAPPAEPCGKGH-RCVNS---PGSFRCECKTGYYFDGISRMCV--DVNECQRYPGR 409
Query: 353 CADRRC--VLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKH 410
+C L ++LC D +CE E C + + +++ C R+
Sbjct: 410 LCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQ-CYCRRG 468
Query: 411 VCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPM-GFLLAEDKYSCR 469
D +D + C L + C CI G C+CP G+ LA + +C+
Sbjct: 469 YQLSDVDGVTCEDIDECALP---TGGHICSYRCINI-PGSFQCSCPSSGYRLAPNGRNCQ 524
Query: 470 DIDECMYE-QDPVCSQTCSNTVGSFRC 495
DIDEC+ + ++TC N G FRC
Sbjct: 525 DIDECVTGIHNCSINETCFNIQGGFRC 551
Score = 35.1 bits (77), Expect = 2.3
Identities = 12/31 (38%), Positives = 18/31 (58%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C H C G C+C +G +L+ DG++C D
Sbjct: 411 CGHKCENTLGSYLCSCSVGFRLSVDGRSCED 441
Score = 34.7 bits (76), Expect = 3.1
Identities = 16/41 (39%), Positives = 22/41 (53%), Gaps = 3/41 (7%)
Query: 1019 CGKNNGG--CSHLCLLKPGGRSCACP-IGIKLNKDGKTCAD 1056
C GG CS+ C+ PG C+CP G +L +G+ C D
Sbjct: 485 CALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQD 525
Score = 34.3 bits (75), Expect = 4.0
Identities = 17/45 (37%), Positives = 20/45 (44%)
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIG 526
C Q C +T C C GY L D SC+ E T S R+G
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLG 230
>Z95331-3|CAI41717.1| 703|Homo sapiens fibulin 1 protein.
Length = 703
Score = 75.8 bits (178), Expect = 1e-12
Identities = 60/243 (24%), Positives = 93/243 (38%), Gaps = 21/243 (8%)
Query: 282 CDGDNDCGDWTDEDSCPMVPGSCNA-GEFKCN-DGKC-----IPERWRCDNERDCADGGD 334
C+ N+C T SC + N G F+C D C + E C + +C G
Sbjct: 214 CEDVNEC--ITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIH 271
Query: 335 ELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ 394
NC P+ I +L + C + ++ D + +C + + ++ C +TC
Sbjct: 272 --NCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIG-HTCINT 328
Query: 395 E--HLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAA 452
E + NC H+ + C D +E P C +C G
Sbjct: 329 EGSYTCQKNVPNCGRGYHLNEEGTRCV--DVDECAPPAEPCGKGHRC-----VNSPGSFR 381
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP 512
C C G+ C D++EC +C C NT+GS+ C C G+ L D RSC+
Sbjct: 382 CECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCED 441
Query: 513 TGE 515
E
Sbjct: 442 INE 444
Score = 68.5 bits (160), Expect = 2e-10
Identities = 74/280 (26%), Positives = 102/280 (36%), Gaps = 32/280 (11%)
Query: 263 CAEIDFECKNT--KCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND-GKCIPE 319
C +ID EC++ C+P DF C N G + G C D +C+
Sbjct: 260 CKDID-ECESGIHNCLP-DFICQ--NTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSI 315
Query: 320 RWRCDNERDCADGGDELNCK---PNSIRNCSLDEY--TCAD-RRCVLKTWLCDGVRDCTN 373
C C + C+ PN R L+E C D C C C N
Sbjct: 316 SAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVN 375
Query: 374 GEDEMNCEVSCEEDQY------TCRPQEHLMSNAFRNCVNR------KHVCDGMKDCPRG 421
CE C+ Y C R C ++ ++C
Sbjct: 376 SPGSFRCE--CKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLS 433
Query: 422 DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAE-DKYSCRDIDECMYEQDP 480
D C +CS+ C + C Y G C C G+ L++ D +C DIDEC
Sbjct: 434 VDGRSCEDINECSSSP-CSQECANVY-GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGG 491
Query: 481 -VCSQTCSNTVGSFRCGC-MTGYILRPDERSCKPTGESPT 518
+CS C N GSF+C C +GY L P+ R+C+ E T
Sbjct: 492 HICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVT 531
Score = 67.7 bits (158), Expect = 4e-10
Identities = 70/262 (26%), Positives = 104/262 (39%), Gaps = 43/262 (16%)
Query: 280 FQCDGDNDCG---DWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDEL 336
F+C D+ CG + T+++SC + C +G C +P+ + C N +L
Sbjct: 240 FRCQRDSSCGTGYELTEDNSCKDID-ECESGIHNC-----LPD-FICQNTLGSFRCRPKL 292
Query: 337 NCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQE 395
CK I++ + C D C+ + C C N E +C+++ C
Sbjct: 293 QCKSGFIQDALGN---CIDINECLSISAPCPIGHTCINTEGSY----TCQKNVPNCGRGY 345
Query: 396 HLMSNAFR-----NCVNRKHVCDGMKDCPRGDDEERCPLK---------RKCSAEEKCEK 441
HL R C C C RC K R C +C++
Sbjct: 346 HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQR 405
Query: 442 ----LCITTYD---GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFR 494
LC + G C+C +GF L+ D SC DI+EC P CSQ C+N GS++
Sbjct: 406 YPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSSP-CSQECANVYGSYQ 462
Query: 495 CGCMTGYILRP-DERSCKPTGE 515
C C GY L D +C+ E
Sbjct: 463 CYCRRGYQLSDVDGVTCEDIDE 484
Score = 62.9 bits (146), Expect = 1e-08
Identities = 37/100 (37%), Positives = 51/100 (51%), Gaps = 8/100 (8%)
Query: 422 DDEERCP-LKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP 480
++E+ P L +C C++ C T D C+C +G+ L D SC D++EC+
Sbjct: 168 EEEQEDPYLNDRCRGGGPCKQQCRDTGD-EVVCSCFVGYQLLSDGVSCEDVNECITGSHS 226
Query: 481 V-CSQTCSNTVGSFRC----GCMTGYILRPDERSCKPTGE 515
++C NTVGSFRC C TGY L D SCK E
Sbjct: 227 CRLGESCINTVGSFRCQRDSSCGTGYELTED-NSCKDIDE 265
Score = 44.4 bits (100), Expect = 0.004
Identities = 50/207 (24%), Positives = 78/207 (37%), Gaps = 15/207 (7%)
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYT 352
D D C C G +C + P +RC+ + G C + C
Sbjct: 356 DVDECAPPAEPCGKGH-RCVNS---PGSFRCECKTGYYFDGISRMCV--DVNECQRYPGR 409
Query: 353 CADRRC--VLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKH 410
+C L ++LC D +CE E C + + +++ C R+
Sbjct: 410 LCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQ-CYCRRG 468
Query: 411 VCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPM-GFLLAEDKYSCR 469
D +D + C L + C CI G C+CP G+ LA + +C+
Sbjct: 469 YQLSDVDGVTCEDIDECALP---TGGHICSYRCINI-PGSFQCSCPSSGYRLAPNGRNCQ 524
Query: 470 DIDECMYE-QDPVCSQTCSNTVGSFRC 495
DIDEC+ + ++TC N G FRC
Sbjct: 525 DIDECVTGIHNCSINETCFNIQGGFRC 551
Score = 35.1 bits (77), Expect = 2.3
Identities = 12/31 (38%), Positives = 18/31 (58%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C H C G C+C +G +L+ DG++C D
Sbjct: 411 CGHKCENTLGSYLCSCSVGFRLSVDGRSCED 441
Score = 34.7 bits (76), Expect = 3.1
Identities = 16/41 (39%), Positives = 22/41 (53%), Gaps = 3/41 (7%)
Query: 1019 CGKNNGG--CSHLCLLKPGGRSCACP-IGIKLNKDGKTCAD 1056
C GG CS+ C+ PG C+CP G +L +G+ C D
Sbjct: 485 CALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQD 525
Score = 34.3 bits (75), Expect = 4.0
Identities = 17/45 (37%), Positives = 20/45 (44%)
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIG 526
C Q C +T C C GY L D SC+ E T S R+G
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLG 230
>X53743-1|CAA37772.1| 683|Homo sapiens fibulin-1 C protein.
Length = 683
Score = 75.8 bits (178), Expect = 1e-12
Identities = 60/243 (24%), Positives = 93/243 (38%), Gaps = 21/243 (8%)
Query: 282 CDGDNDCGDWTDEDSCPMVPGSCNA-GEFKCN-DGKC-----IPERWRCDNERDCADGGD 334
C+ N+C T SC + N G F+C D C + E C + +C G
Sbjct: 214 CEDVNEC--ITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIH 271
Query: 335 ELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ 394
NC P+ I +L + C + ++ D + +C + + ++ C +TC
Sbjct: 272 --NCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIG-HTCINT 328
Query: 395 E--HLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAA 452
E + NC H+ + C D +E P C +C G
Sbjct: 329 EGSYTCQKNVPNCGRGYHLNEEGTRCV--DVDECAPPAEPCGKGHRC-----VNSPGSFR 381
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP 512
C C G+ C D++EC +C C NT+GS+ C C G+ L D RSC+
Sbjct: 382 CECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCED 441
Query: 513 TGE 515
E
Sbjct: 442 INE 444
Score = 68.5 bits (160), Expect = 2e-10
Identities = 74/280 (26%), Positives = 102/280 (36%), Gaps = 32/280 (11%)
Query: 263 CAEIDFECKNT--KCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND-GKCIPE 319
C +ID EC++ C+P DF C N G + G C D +C+
Sbjct: 260 CKDID-ECESGIHNCLP-DFICQ--NTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSI 315
Query: 320 RWRCDNERDCADGGDELNCK---PNSIRNCSLDEY--TCAD-RRCVLKTWLCDGVRDCTN 373
C C + C+ PN R L+E C D C C C N
Sbjct: 316 SAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVN 375
Query: 374 GEDEMNCEVSCEEDQY------TCRPQEHLMSNAFRNCVNR------KHVCDGMKDCPRG 421
CE C+ Y C R C ++ ++C
Sbjct: 376 SPGSFRCE--CKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLS 433
Query: 422 DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAE-DKYSCRDIDECMYEQDP 480
D C +CS+ C + C Y G C C G+ L++ D +C DIDEC
Sbjct: 434 VDGRSCEDINECSSSP-CSQECANVY-GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGG 491
Query: 481 -VCSQTCSNTVGSFRCGC-MTGYILRPDERSCKPTGESPT 518
+CS C N GSF+C C +GY L P+ R+C+ E T
Sbjct: 492 HICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVT 531
Score = 67.7 bits (158), Expect = 4e-10
Identities = 70/262 (26%), Positives = 104/262 (39%), Gaps = 43/262 (16%)
Query: 280 FQCDGDNDCG---DWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDEL 336
F+C D+ CG + T+++SC + C +G C +P+ + C N +L
Sbjct: 240 FRCQRDSSCGTGYELTEDNSCKDID-ECESGIHNC-----LPD-FICQNTLGSFRCRPKL 292
Query: 337 NCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQE 395
CK I++ + C D C+ + C C N E +C+++ C
Sbjct: 293 QCKSGFIQDALGN---CIDINECLSISAPCPIGHTCINTEGSY----TCQKNVPNCGRGY 345
Query: 396 HLMSNAFR-----NCVNRKHVCDGMKDCPRGDDEERCPLK---------RKCSAEEKCEK 441
HL R C C C RC K R C +C++
Sbjct: 346 HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQR 405
Query: 442 ----LCITTYD---GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFR 494
LC + G C+C +GF L+ D SC DI+EC P CSQ C+N GS++
Sbjct: 406 YPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSSP-CSQECANVYGSYQ 462
Query: 495 CGCMTGYILRP-DERSCKPTGE 515
C C GY L D +C+ E
Sbjct: 463 CYCRRGYQLSDVDGVTCEDIDE 484
Score = 62.9 bits (146), Expect = 1e-08
Identities = 37/100 (37%), Positives = 51/100 (51%), Gaps = 8/100 (8%)
Query: 422 DDEERCP-LKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP 480
++E+ P L +C C++ C T D C+C +G+ L D SC D++EC+
Sbjct: 168 EEEQEDPYLNDRCRGGGPCKQQCRDTGD-EVVCSCFVGYQLLSDGVSCEDVNECITGSHS 226
Query: 481 V-CSQTCSNTVGSFRC----GCMTGYILRPDERSCKPTGE 515
++C NTVGSFRC C TGY L D SCK E
Sbjct: 227 CRLGESCINTVGSFRCQRDSSCGTGYELTED-NSCKDIDE 265
Score = 44.8 bits (101), Expect = 0.003
Identities = 50/207 (24%), Positives = 79/207 (38%), Gaps = 15/207 (7%)
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYT 352
D D C C G +C + P +RC+ + G C + C
Sbjct: 356 DVDECAPPAEPCGKGH-RCVNS---PGSFRCECKTGYYFDGISRMCV--DVNECQRYPGR 409
Query: 353 CADRRC--VLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKH 410
+C L ++LC D +CE E C + + +++ C R+
Sbjct: 410 LCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQ-CYCRRG 468
Query: 411 VCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPM-GFLLAEDKYSCR 469
D +D + C L + C CI G C+CP G+ LA + +C+
Sbjct: 469 YQLSDVDGVTCEDIDECALP---TGGHICSYRCINI-PGSFQCSCPSSGYRLAPNGRNCQ 524
Query: 470 DIDECMYE-QDPVCSQTCSNTVGSFRC 495
DIDEC+ + ++TC N G+FRC
Sbjct: 525 DIDECVTGIHNCSINETCFNIQGAFRC 551
Score = 35.1 bits (77), Expect = 2.3
Identities = 12/31 (38%), Positives = 18/31 (58%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C H C G C+C +G +L+ DG++C D
Sbjct: 411 CGHKCENTLGSYLCSCSVGFRLSVDGRSCED 441
Score = 34.7 bits (76), Expect = 3.1
Identities = 16/41 (39%), Positives = 22/41 (53%), Gaps = 3/41 (7%)
Query: 1019 CGKNNGG--CSHLCLLKPGGRSCACP-IGIKLNKDGKTCAD 1056
C GG CS+ C+ PG C+CP G +L +G+ C D
Sbjct: 485 CALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQD 525
Score = 34.3 bits (75), Expect = 4.0
Identities = 17/45 (37%), Positives = 20/45 (44%)
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIG 526
C Q C +T C C GY L D SC+ E T S R+G
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLG 230
>X53742-1|CAA37771.1| 601|Homo sapiens fibulin-1 B protein.
Length = 601
Score = 75.8 bits (178), Expect = 1e-12
Identities = 60/243 (24%), Positives = 93/243 (38%), Gaps = 21/243 (8%)
Query: 282 CDGDNDCGDWTDEDSCPMVPGSCNA-GEFKCN-DGKC-----IPERWRCDNERDCADGGD 334
C+ N+C T SC + N G F+C D C + E C + +C G
Sbjct: 214 CEDVNEC--ITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIH 271
Query: 335 ELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ 394
NC P+ I +L + C + ++ D + +C + + ++ C +TC
Sbjct: 272 --NCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIG-HTCINT 328
Query: 395 E--HLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAA 452
E + NC H+ + C D +E P C +C G
Sbjct: 329 EGSYTCQKNVPNCGRGYHLNEEGTRCV--DVDECAPPAEPCGKGHRC-----VNSPGSFR 381
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP 512
C C G+ C D++EC +C C NT+GS+ C C G+ L D RSC+
Sbjct: 382 CECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCED 441
Query: 513 TGE 515
E
Sbjct: 442 INE 444
Score = 68.5 bits (160), Expect = 2e-10
Identities = 74/280 (26%), Positives = 102/280 (36%), Gaps = 32/280 (11%)
Query: 263 CAEIDFECKNT--KCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND-GKCIPE 319
C +ID EC++ C+P DF C N G + G C D +C+
Sbjct: 260 CKDID-ECESGIHNCLP-DFICQ--NTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSI 315
Query: 320 RWRCDNERDCADGGDELNCK---PNSIRNCSLDEY--TCAD-RRCVLKTWLCDGVRDCTN 373
C C + C+ PN R L+E C D C C C N
Sbjct: 316 SAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVN 375
Query: 374 GEDEMNCEVSCEEDQY------TCRPQEHLMSNAFRNCVNR------KHVCDGMKDCPRG 421
CE C+ Y C R C ++ ++C
Sbjct: 376 SPGSFRCE--CKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLS 433
Query: 422 DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAE-DKYSCRDIDECMYEQDP 480
D C +CS+ C + C Y G C C G+ L++ D +C DIDEC
Sbjct: 434 VDGRSCEDINECSSSP-CSQECANVY-GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGG 491
Query: 481 -VCSQTCSNTVGSFRCGC-MTGYILRPDERSCKPTGESPT 518
+CS C N GSF+C C +GY L P+ R+C+ E T
Sbjct: 492 HICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVT 531
Score = 67.7 bits (158), Expect = 4e-10
Identities = 70/262 (26%), Positives = 104/262 (39%), Gaps = 43/262 (16%)
Query: 280 FQCDGDNDCG---DWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDEL 336
F+C D+ CG + T+++SC + C +G C +P+ + C N +L
Sbjct: 240 FRCQRDSSCGTGYELTEDNSCKDID-ECESGIHNC-----LPD-FICQNTLGSFRCRPKL 292
Query: 337 NCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQE 395
CK I++ + C D C+ + C C N E +C+++ C
Sbjct: 293 QCKSGFIQDALGN---CIDINECLSISAPCPIGHTCINTEGSY----TCQKNVPNCGRGY 345
Query: 396 HLMSNAFR-----NCVNRKHVCDGMKDCPRGDDEERCPLK---------RKCSAEEKCEK 441
HL R C C C RC K R C +C++
Sbjct: 346 HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQR 405
Query: 442 ----LCITTYD---GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFR 494
LC + G C+C +GF L+ D SC DI+EC P CSQ C+N GS++
Sbjct: 406 YPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSSP-CSQECANVYGSYQ 462
Query: 495 CGCMTGYILRP-DERSCKPTGE 515
C C GY L D +C+ E
Sbjct: 463 CYCRRGYQLSDVDGVTCEDIDE 484
Score = 62.9 bits (146), Expect = 1e-08
Identities = 37/100 (37%), Positives = 51/100 (51%), Gaps = 8/100 (8%)
Query: 422 DDEERCP-LKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP 480
++E+ P L +C C++ C T D C+C +G+ L D SC D++EC+
Sbjct: 168 EEEQEDPYLNDRCRGGGPCKQQCRDTGD-EVVCSCFVGYQLLSDGVSCEDVNECITGSHS 226
Query: 481 V-CSQTCSNTVGSFRC----GCMTGYILRPDERSCKPTGE 515
++C NTVGSFRC C TGY L D SCK E
Sbjct: 227 CRLGESCINTVGSFRCQRDSSCGTGYELTED-NSCKDIDE 265
Score = 44.8 bits (101), Expect = 0.003
Identities = 50/207 (24%), Positives = 79/207 (38%), Gaps = 15/207 (7%)
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYT 352
D D C C G +C + P +RC+ + G C + C
Sbjct: 356 DVDECAPPAEPCGKGH-RCVNS---PGSFRCECKTGYYFDGISRMCV--DVNECQRYPGR 409
Query: 353 CADRRC--VLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKH 410
+C L ++LC D +CE E C + + +++ C R+
Sbjct: 410 LCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQ-CYCRRG 468
Query: 411 VCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPM-GFLLAEDKYSCR 469
D +D + C L + C CI G C+CP G+ LA + +C+
Sbjct: 469 YQLSDVDGVTCEDIDECALP---TGGHICSYRCINI-PGSFQCSCPSSGYRLAPNGRNCQ 524
Query: 470 DIDECMYE-QDPVCSQTCSNTVGSFRC 495
DIDEC+ + ++TC N G+FRC
Sbjct: 525 DIDECVTGIHNCSINETCFNIQGAFRC 551
Score = 35.1 bits (77), Expect = 2.3
Identities = 12/31 (38%), Positives = 18/31 (58%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C H C G C+C +G +L+ DG++C D
Sbjct: 411 CGHKCENTLGSYLCSCSVGFRLSVDGRSCED 441
Score = 34.7 bits (76), Expect = 3.1
Identities = 16/41 (39%), Positives = 22/41 (53%), Gaps = 3/41 (7%)
Query: 1019 CGKNNGG--CSHLCLLKPGGRSCACP-IGIKLNKDGKTCAD 1056
C GG CS+ C+ PG C+CP G +L +G+ C D
Sbjct: 485 CALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQD 525
Score = 34.3 bits (75), Expect = 4.0
Identities = 17/45 (37%), Positives = 20/45 (44%)
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIG 526
C Q C +T C C GY L D SC+ E T S R+G
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLG 230
>X53741-1|CAA37770.1| 566|Homo sapiens fibulin-1 A protein.
Length = 566
Score = 75.8 bits (178), Expect = 1e-12
Identities = 60/243 (24%), Positives = 93/243 (38%), Gaps = 21/243 (8%)
Query: 282 CDGDNDCGDWTDEDSCPMVPGSCNA-GEFKCN-DGKC-----IPERWRCDNERDCADGGD 334
C+ N+C T SC + N G F+C D C + E C + +C G
Sbjct: 214 CEDVNEC--ITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIH 271
Query: 335 ELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ 394
NC P+ I +L + C + ++ D + +C + + ++ C +TC
Sbjct: 272 --NCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIG-HTCINT 328
Query: 395 E--HLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAA 452
E + NC H+ + C D +E P C +C G
Sbjct: 329 EGSYTCQKNVPNCGRGYHLNEEGTRCV--DVDECAPPAEPCGKGHRC-----VNSPGSFR 381
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP 512
C C G+ C D++EC +C C NT+GS+ C C G+ L D RSC+
Sbjct: 382 CECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCED 441
Query: 513 TGE 515
E
Sbjct: 442 INE 444
Score = 68.5 bits (160), Expect = 2e-10
Identities = 74/280 (26%), Positives = 102/280 (36%), Gaps = 32/280 (11%)
Query: 263 CAEIDFECKNT--KCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND-GKCIPE 319
C +ID EC++ C+P DF C N G + G C D +C+
Sbjct: 260 CKDID-ECESGIHNCLP-DFICQ--NTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSI 315
Query: 320 RWRCDNERDCADGGDELNCK---PNSIRNCSLDEY--TCAD-RRCVLKTWLCDGVRDCTN 373
C C + C+ PN R L+E C D C C C N
Sbjct: 316 SAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVN 375
Query: 374 GEDEMNCEVSCEEDQY------TCRPQEHLMSNAFRNCVNR------KHVCDGMKDCPRG 421
CE C+ Y C R C ++ ++C
Sbjct: 376 SPGSFRCE--CKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLS 433
Query: 422 DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAE-DKYSCRDIDECMYEQDP 480
D C +CS+ C + C Y G C C G+ L++ D +C DIDEC
Sbjct: 434 VDGRSCEDINECSSSP-CSQECANVY-GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGG 491
Query: 481 -VCSQTCSNTVGSFRCGC-MTGYILRPDERSCKPTGESPT 518
+CS C N GSF+C C +GY L P+ R+C+ E T
Sbjct: 492 HICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVT 531
Score = 67.7 bits (158), Expect = 4e-10
Identities = 70/262 (26%), Positives = 104/262 (39%), Gaps = 43/262 (16%)
Query: 280 FQCDGDNDCG---DWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDEL 336
F+C D+ CG + T+++SC + C +G C +P+ + C N +L
Sbjct: 240 FRCQRDSSCGTGYELTEDNSCKDID-ECESGIHNC-----LPD-FICQNTLGSFRCRPKL 292
Query: 337 NCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQE 395
CK I++ + C D C+ + C C N E +C+++ C
Sbjct: 293 QCKSGFIQDALGN---CIDINECLSISAPCPIGHTCINTEGSY----TCQKNVPNCGRGY 345
Query: 396 HLMSNAFR-----NCVNRKHVCDGMKDCPRGDDEERCPLK---------RKCSAEEKCEK 441
HL R C C C RC K R C +C++
Sbjct: 346 HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQR 405
Query: 442 ----LCITTYD---GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFR 494
LC + G C+C +GF L+ D SC DI+EC P CSQ C+N GS++
Sbjct: 406 YPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSSP-CSQECANVYGSYQ 462
Query: 495 CGCMTGYILRP-DERSCKPTGE 515
C C GY L D +C+ E
Sbjct: 463 CYCRRGYQLSDVDGVTCEDIDE 484
Score = 62.9 bits (146), Expect = 1e-08
Identities = 37/100 (37%), Positives = 51/100 (51%), Gaps = 8/100 (8%)
Query: 422 DDEERCP-LKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP 480
++E+ P L +C C++ C T D C+C +G+ L D SC D++EC+
Sbjct: 168 EEEQEDPYLNDRCRGGGPCKQQCRDTGD-EVVCSCFVGYQLLSDGVSCEDVNECITGSHS 226
Query: 481 V-CSQTCSNTVGSFRC----GCMTGYILRPDERSCKPTGE 515
++C NTVGSFRC C TGY L D SCK E
Sbjct: 227 CRLGESCINTVGSFRCQRDSSCGTGYELTED-NSCKDIDE 265
Score = 44.8 bits (101), Expect = 0.003
Identities = 50/207 (24%), Positives = 79/207 (38%), Gaps = 15/207 (7%)
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYT 352
D D C C G +C + P +RC+ + G C + C
Sbjct: 356 DVDECAPPAEPCGKGH-RCVNS---PGSFRCECKTGYYFDGISRMCV--DVNECQRYPGR 409
Query: 353 CADRRC--VLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKH 410
+C L ++LC D +CE E C + + +++ C R+
Sbjct: 410 LCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQ-CYCRRG 468
Query: 411 VCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPM-GFLLAEDKYSCR 469
D +D + C L + C CI G C+CP G+ LA + +C+
Sbjct: 469 YQLSDVDGVTCEDIDECALP---TGGHICSYRCINI-PGSFQCSCPSSGYRLAPNGRNCQ 524
Query: 470 DIDECMYE-QDPVCSQTCSNTVGSFRC 495
DIDEC+ + ++TC N G+FRC
Sbjct: 525 DIDECVTGIHNCSINETCFNIQGAFRC 551
Score = 35.1 bits (77), Expect = 2.3
Identities = 12/31 (38%), Positives = 18/31 (58%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C H C G C+C +G +L+ DG++C D
Sbjct: 411 CGHKCENTLGSYLCSCSVGFRLSVDGRSCED 441
Score = 34.7 bits (76), Expect = 3.1
Identities = 16/41 (39%), Positives = 22/41 (53%), Gaps = 3/41 (7%)
Query: 1019 CGKNNGG--CSHLCLLKPGGRSCACP-IGIKLNKDGKTCAD 1056
C GG CS+ C+ PG C+CP G +L +G+ C D
Sbjct: 485 CALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQD 525
Score = 34.3 bits (75), Expect = 4.0
Identities = 17/45 (37%), Positives = 20/45 (44%)
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIG 526
C Q C +T C C GY L D SC+ E T S R+G
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLG 230
>U01244-1|AAB17099.1| 703|Homo sapiens fibulin-1D protein.
Length = 703
Score = 75.8 bits (178), Expect = 1e-12
Identities = 60/243 (24%), Positives = 93/243 (38%), Gaps = 21/243 (8%)
Query: 282 CDGDNDCGDWTDEDSCPMVPGSCNA-GEFKCN-DGKC-----IPERWRCDNERDCADGGD 334
C+ N+C T SC + N G F+C D C + E C + +C G
Sbjct: 214 CEDVNEC--ITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIH 271
Query: 335 ELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ 394
NC P+ I +L + C + ++ D + +C + + ++ C +TC
Sbjct: 272 --NCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIG-HTCINT 328
Query: 395 E--HLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAA 452
E + NC H+ + C D +E P C +C G
Sbjct: 329 EGSYTCQKNVPNCGRGYHLNEEGTRCV--DVDECAPPAEPCGKGHRC-----VNSPGSFR 381
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP 512
C C G+ C D++EC +C C NT+GS+ C C G+ L D RSC+
Sbjct: 382 CECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCED 441
Query: 513 TGE 515
E
Sbjct: 442 INE 444
Score = 68.5 bits (160), Expect = 2e-10
Identities = 74/280 (26%), Positives = 102/280 (36%), Gaps = 32/280 (11%)
Query: 263 CAEIDFECKNT--KCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND-GKCIPE 319
C +ID EC++ C+P DF C N G + G C D +C+
Sbjct: 260 CKDID-ECESGIHNCLP-DFICQ--NTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSI 315
Query: 320 RWRCDNERDCADGGDELNCK---PNSIRNCSLDEY--TCAD-RRCVLKTWLCDGVRDCTN 373
C C + C+ PN R L+E C D C C C N
Sbjct: 316 SAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVN 375
Query: 374 GEDEMNCEVSCEEDQY------TCRPQEHLMSNAFRNCVNR------KHVCDGMKDCPRG 421
CE C+ Y C R C ++ ++C
Sbjct: 376 SPGSFRCE--CKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLS 433
Query: 422 DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAE-DKYSCRDIDECMYEQDP 480
D C +CS+ C + C Y G C C G+ L++ D +C DIDEC
Sbjct: 434 VDGRSCEDINECSSSP-CSQECANVY-GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGG 491
Query: 481 -VCSQTCSNTVGSFRCGC-MTGYILRPDERSCKPTGESPT 518
+CS C N GSF+C C +GY L P+ R+C+ E T
Sbjct: 492 HICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVT 531
Score = 67.7 bits (158), Expect = 4e-10
Identities = 70/262 (26%), Positives = 104/262 (39%), Gaps = 43/262 (16%)
Query: 280 FQCDGDNDCG---DWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDEL 336
F+C D+ CG + T+++SC + C +G C +P+ + C N +L
Sbjct: 240 FRCQRDSSCGTGYELTEDNSCKDID-ECESGIHNC-----LPD-FICQNTLGSFRCRPKL 292
Query: 337 NCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQE 395
CK I++ + C D C+ + C C N E +C+++ C
Sbjct: 293 QCKSGFIQDALGN---CIDINECLSISAPCPIGHTCINTEGSY----TCQKNVPNCGRGY 345
Query: 396 HLMSNAFR-----NCVNRKHVCDGMKDCPRGDDEERCPLK---------RKCSAEEKCEK 441
HL R C C C RC K R C +C++
Sbjct: 346 HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQR 405
Query: 442 ----LCITTYD---GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFR 494
LC + G C+C +GF L+ D SC DI+EC P CSQ C+N GS++
Sbjct: 406 YPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSSP-CSQECANVYGSYQ 462
Query: 495 CGCMTGYILRP-DERSCKPTGE 515
C C GY L D +C+ E
Sbjct: 463 CYCRRGYQLSDVDGVTCEDIDE 484
Score = 62.9 bits (146), Expect = 1e-08
Identities = 37/100 (37%), Positives = 51/100 (51%), Gaps = 8/100 (8%)
Query: 422 DDEERCP-LKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP 480
++E+ P L +C C++ C T D C+C +G+ L D SC D++EC+
Sbjct: 168 EEEQEDPYLNDRCRGGGPCKQQCRDTGD-EVVCSCFVGYQLLSDGVSCEDVNECITGSHS 226
Query: 481 V-CSQTCSNTVGSFRC----GCMTGYILRPDERSCKPTGE 515
++C NTVGSFRC C TGY L D SCK E
Sbjct: 227 CRLGESCINTVGSFRCQRDSSCGTGYELTED-NSCKDIDE 265
Score = 44.8 bits (101), Expect = 0.003
Identities = 50/207 (24%), Positives = 79/207 (38%), Gaps = 15/207 (7%)
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYT 352
D D C C G +C + P +RC+ + G C + C
Sbjct: 356 DVDECAPPAEPCGKGH-RCVNS---PGSFRCECKTGYYFDGISRMCV--DVNECQRYPGR 409
Query: 353 CADRRC--VLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKH 410
+C L ++LC D +CE E C + + +++ C R+
Sbjct: 410 LCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQ-CYCRRG 468
Query: 411 VCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPM-GFLLAEDKYSCR 469
D +D + C L + C CI G C+CP G+ LA + +C+
Sbjct: 469 YQLSDVDGVTCEDIDECALP---TGGHICSYRCINI-PGSFQCSCPSSGYRLAPNGRNCQ 524
Query: 470 DIDECMYE-QDPVCSQTCSNTVGSFRC 495
DIDEC+ + ++TC N G+FRC
Sbjct: 525 DIDECVTGIHNCSINETCFNIQGAFRC 551
Score = 35.1 bits (77), Expect = 2.3
Identities = 12/31 (38%), Positives = 18/31 (58%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C H C G C+C +G +L+ DG++C D
Sbjct: 411 CGHKCENTLGSYLCSCSVGFRLSVDGRSCED 441
Score = 34.7 bits (76), Expect = 3.1
Identities = 16/41 (39%), Positives = 22/41 (53%), Gaps = 3/41 (7%)
Query: 1019 CGKNNGG--CSHLCLLKPGGRSCACP-IGIKLNKDGKTCAD 1056
C GG CS+ C+ PG C+CP G +L +G+ C D
Sbjct: 485 CALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQD 525
Score = 34.3 bits (75), Expect = 4.0
Identities = 17/45 (37%), Positives = 20/45 (44%)
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIG 526
C Q C +T C C GY L D SC+ E T S R+G
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLG 230
>BC022497-1|AAH22497.1| 683|Homo sapiens fibulin 1 protein.
Length = 683
Score = 75.8 bits (178), Expect = 1e-12
Identities = 60/243 (24%), Positives = 93/243 (38%), Gaps = 21/243 (8%)
Query: 282 CDGDNDCGDWTDEDSCPMVPGSCNA-GEFKCN-DGKC-----IPERWRCDNERDCADGGD 334
C+ N+C T SC + N G F+C D C + E C + +C G
Sbjct: 214 CEDVNEC--ITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIH 271
Query: 335 ELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ 394
NC P+ I +L + C + ++ D + +C + + ++ C +TC
Sbjct: 272 --NCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIG-HTCINT 328
Query: 395 E--HLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAA 452
E + NC H+ + C D +E P C +C G
Sbjct: 329 EGSYTCQKNVPNCGRGYHLNEEGTRCV--DVDECAPPAEPCGKGHRC-----VNSPGSFR 381
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP 512
C C G+ C D++EC +C C NT+GS+ C C G+ L D RSC+
Sbjct: 382 CECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCED 441
Query: 513 TGE 515
E
Sbjct: 442 INE 444
Score = 67.7 bits (158), Expect = 4e-10
Identities = 70/262 (26%), Positives = 104/262 (39%), Gaps = 43/262 (16%)
Query: 280 FQCDGDNDCG---DWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDEL 336
F+C D+ CG + T+++SC + C +G C +P+ + C N +L
Sbjct: 240 FRCQRDSSCGTGYELTEDNSCKDID-ECESGIHNC-----LPD-FICQNTLGSFRCRPKL 292
Query: 337 NCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQE 395
CK I++ + C D C+ + C C N E +C+++ C
Sbjct: 293 QCKSGFIQDALGN---CIDINECLSISAPCPIGHTCINTEGSY----TCQKNVPNCGRGY 345
Query: 396 HLMSNAFR-----NCVNRKHVCDGMKDCPRGDDEERCPLK---------RKCSAEEKCEK 441
HL R C C C RC K R C +C++
Sbjct: 346 HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQR 405
Query: 442 ----LCITTYD---GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFR 494
LC + G C+C +GF L+ D SC DI+EC P CSQ C+N GS++
Sbjct: 406 YPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSSP-CSQECANVYGSYQ 462
Query: 495 CGCMTGYILRP-DERSCKPTGE 515
C C GY L D +C+ E
Sbjct: 463 CYCRRGYQLSDVDGVTCEDIDE 484
Score = 66.1 bits (154), Expect = 1e-09
Identities = 73/280 (26%), Positives = 101/280 (36%), Gaps = 32/280 (11%)
Query: 263 CAEIDFECKNT--KCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND-GKCIPE 319
C +ID EC++ C+P DF C N G + G C D +C+
Sbjct: 260 CKDID-ECESGIHNCLP-DFICQ--NTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSI 315
Query: 320 RWRCDNERDCADGGDELNCK---PNSIRNCSLDEY--TCAD-RRCVLKTWLCDGVRDCTN 373
C C + C+ PN R L+E C D C C C N
Sbjct: 316 SAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVN 375
Query: 374 GEDEMNCEVSCEEDQY------TCRPQEHLMSNAFRNCVNR------KHVCDGMKDCPRG 421
CE C+ Y C R C ++ ++C
Sbjct: 376 SPGSFRCE--CKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLS 433
Query: 422 DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAE-DKYSCRDIDECMYEQDP 480
D C +CS+ C + C Y G C C G+ L++ D +C DIDEC
Sbjct: 434 VDGRSCEDINECSSSP-CSQECANVY-GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGG 491
Query: 481 -VCSQTCSNTVGSFRCGC-MTGYILRPDERSCKPTGESPT 518
+CS C N GSF+C C +GY L P+ +C+ E T
Sbjct: 492 HICSYRCINIPGSFQCSCPSSGYRLAPNGSNCQDIDECVT 531
Score = 62.9 bits (146), Expect = 1e-08
Identities = 37/100 (37%), Positives = 51/100 (51%), Gaps = 8/100 (8%)
Query: 422 DDEERCP-LKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP 480
++E+ P L +C C++ C T D C+C +G+ L D SC D++EC+
Sbjct: 168 EEEQEDPYLNDRCRGGGPCKQQCRDTGD-EVVCSCFVGYQLLSDGVSCEDVNECITGSHS 226
Query: 481 V-CSQTCSNTVGSFRC----GCMTGYILRPDERSCKPTGE 515
++C NTVGSFRC C TGY L D SCK E
Sbjct: 227 CRLGESCINTVGSFRCQRDSSCGTGYELTED-NSCKDIDE 265
Score = 44.4 bits (100), Expect = 0.004
Identities = 50/207 (24%), Positives = 78/207 (37%), Gaps = 15/207 (7%)
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYT 352
D D C C G +C + P +RC+ + G C + C
Sbjct: 356 DVDECAPPAEPCGKGH-RCVNS---PGSFRCECKTGYYFDGISRMCV--DVNECQRYPGR 409
Query: 353 CADRRC--VLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKH 410
+C L ++LC D +CE E C + + +++ C R+
Sbjct: 410 LCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQ-CYCRRG 468
Query: 411 VCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPM-GFLLAEDKYSCR 469
D +D + C L + C CI G C+CP G+ LA + +C+
Sbjct: 469 YQLSDVDGVTCEDIDECALP---TGGHICSYRCINI-PGSFQCSCPSSGYRLAPNGSNCQ 524
Query: 470 DIDECMYE-QDPVCSQTCSNTVGSFRC 495
DIDEC+ + ++TC N G FRC
Sbjct: 525 DIDECVTGIHNCSINETCFNIQGGFRC 551
Score = 35.1 bits (77), Expect = 2.3
Identities = 12/31 (38%), Positives = 18/31 (58%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C H C G C+C +G +L+ DG++C D
Sbjct: 411 CGHKCENTLGSYLCSCSVGFRLSVDGRSCED 441
Score = 34.3 bits (75), Expect = 4.0
Identities = 17/45 (37%), Positives = 20/45 (44%)
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIG 526
C Q C +T C C GY L D SC+ E T S R+G
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLG 230
Score = 33.9 bits (74), Expect = 5.3
Identities = 16/41 (39%), Positives = 21/41 (51%), Gaps = 3/41 (7%)
Query: 1019 CGKNNGG--CSHLCLLKPGGRSCACP-IGIKLNKDGKTCAD 1056
C GG CS+ C+ PG C+CP G +L +G C D
Sbjct: 485 CALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGSNCQD 525
>BC016394-1|AAH16394.1| 715|Homo sapiens MATN2 protein protein.
Length = 715
Score = 75.8 bits (178), Expect = 1e-12
Identities = 50/171 (29%), Positives = 76/171 (44%), Gaps = 16/171 (9%)
Query: 346 CSLDEYTCADRRCVL--KTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFR 403
CS E+ CA C+ +++C + D+ C + Q C ++H N +
Sbjct: 1 CSTLEHNCA-HFCINIPGSYVCRCKQGYILNSDQTTCRI-----QDLCAMEDH---NCEQ 51
Query: 404 NCVN--RKHVCDGMKDCPRGDDEERCPLKRKCSAEEK-CEKLCITTYDGHAACACPMGFL 460
CVN VC +D +RC C++E CE C+ DG C C GF
Sbjct: 52 LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNA-DGSYLCQCHEGFA 110
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCK 511
L D+ +C ID C + C C NT S+ C C+ G+ L PD+++C+
Sbjct: 111 LNPDEKTCTKIDYCA-SSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCR 160
Score = 72.5 bits (170), Expect = 1e-11
Identities = 65/263 (24%), Positives = 104/263 (39%), Gaps = 27/263 (10%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPG-SCNAGEFKCND-GKCIPE 319
RC +D+ C ++ C+ ++C + C G + N E C C
Sbjct: 76 RCVAVDY------CASENHGCE--HECVNADGSYLCQCHEGFALNPDEKTCTKIDYCASS 127
Query: 320 RWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEM 378
C +E C + D +C + D+ TC C L C+ +C N E+
Sbjct: 128 NHGCQHE--CVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCE--HECVNMEESY 183
Query: 379 NCEV----SCEEDQYTCRPQEHLMSNAF---RNCVNRKH--VCDGMKDCPRGDDEERCPL 429
C + + + TC +H + C+N + VC + +D + C
Sbjct: 184 YCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSR 243
Query: 430 KRKCS-AEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSN 488
C ++ CE C+ D AC CP G +L D +C +D C D C +C +
Sbjct: 244 VDYCLLSDHGCEYSCVNM-DRSFACQCPEGHVLRSDGKTCAKLDSCALG-DHGCEHSCVS 301
Query: 489 TVGSFRCGCMTGYILRPDERSCK 511
+ SF C C GYILR D ++C+
Sbjct: 302 SEDSFVCQCFEGYILREDGKTCR 324
Score = 68.1 bits (159), Expect = 3e-10
Identities = 68/237 (28%), Positives = 95/237 (40%), Gaps = 39/237 (16%)
Query: 310 KCNDGKCI-PERWRCDNERDCA--DGGDE---LNCKPNSIRNCSLDEYTCADRRCVLKTW 363
+C+ G + P C CA D G E LN + + + CS D LKT
Sbjct: 186 RCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINED----LKT- 240
Query: 364 LCDGVRDCTNGEDEMNCEVSCE--EDQYTCR-PQEHLMSNAFRNCVNR----------KH 410
C V C + CE SC + + C+ P+ H++ + + C +H
Sbjct: 241 -CSRVDYCLLSDH--GCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEH 297
Query: 411 VCDGMKD-----CPRG----DDEERCPLKRKCSA-EEKCEKLCITTYDGHAACACPMGFL 460
C +D C G +D + C K C A + CE +C+ + D + C C GF
Sbjct: 298 SCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYT-CECLEGFR 356
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESP 517
LAED CR D C C C N S+ C C G++L D R CK E P
Sbjct: 357 LAEDGKRCRRKDVCKSTHHG-CEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGP 412
Score = 39.9 bits (89), Expect = 0.081
Identities = 16/36 (44%), Positives = 17/36 (47%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C N GC H C+ G C C G LN D KTC
Sbjct: 83 CASENHGCEHECVNADGSYLCQCHEGFALNPDEKTC 118
Score = 39.9 bits (89), Expect = 0.081
Identities = 22/57 (38%), Positives = 25/57 (43%), Gaps = 2/57 (3%)
Query: 1005 AANKDTGAKRRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINY 1061
A N D + C +N GC H C+ SC C G LN D KTC INY
Sbjct: 110 ALNPDEKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCR--RINY 164
Score = 38.7 bits (86), Expect = 0.19
Identities = 20/54 (37%), Positives = 27/54 (50%), Gaps = 4/54 (7%)
Query: 1014 RRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDG---KTCADGPINYLIF 1064
RR C + GC H+C+ C C G L +DG K C +GPI+ L+F
Sbjct: 365 RRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPID-LVF 417
Score = 38.3 bits (85), Expect = 0.25
Identities = 18/49 (36%), Positives = 22/49 (44%)
Query: 1007 NKDTGAKRRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCA 1055
N D RR C N GC H C+ C C G L+ +GKTC+
Sbjct: 153 NPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCS 201
Score = 37.9 bits (84), Expect = 0.33
Identities = 18/49 (36%), Positives = 24/49 (48%)
Query: 1007 NKDTGAKRRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCA 1055
N+D R C ++ GC + C+ +C CP G L DGKTCA
Sbjct: 235 NEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCA 283
Score = 37.1 bits (82), Expect = 0.57
Identities = 11/25 (44%), Positives = 17/25 (68%)
Query: 1631 CKESNGGCSHLCLFRGHEYICACPD 1655
CK ++ GC H+C+ G+ YIC C +
Sbjct: 370 CKSTHHGCEHICVNNGNSYICKCSE 394
Score = 36.7 bits (81), Expect = 0.76
Identities = 18/59 (30%), Positives = 30/59 (50%), Gaps = 3/59 (5%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINY-LIFAHRVDIRVISLD 1076
C + + GC LCL C C G +N+D KTC+ ++Y L+ H + +++D
Sbjct: 206 CAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCS--RVDYCLLSDHGCEYSCVNMD 262
Score = 36.7 bits (81), Expect = 0.76
Identities = 18/59 (30%), Positives = 29/59 (49%), Gaps = 3/59 (5%)
Query: 1319 ENACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGS 1377
++ C + + GC H+C+ + Y C C G F + + KKC P + L+F GS
Sbjct: 367 KDVCKSTHHGCEHICVNNGNSYICKCSEG--FVLAEDGRRCKKCTEGPID-LVFVIDGS 422
Score = 36.3 bits (80), Expect = 1.00
Identities = 15/41 (36%), Positives = 21/41 (51%)
Query: 1014 RRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
RR C + GC H+C+ +C C G +L +DGK C
Sbjct: 324 RRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRC 364
Score = 35.1 bits (77), Expect = 2.3
Identities = 14/36 (38%), Positives = 16/36 (44%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C C+H C+ PG C C G LN D TC
Sbjct: 1 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTC 36
Score = 35.1 bits (77), Expect = 2.3
Identities = 14/36 (38%), Positives = 17/36 (47%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C + C LC+ PG C C G L +DGK C
Sbjct: 42 CAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRC 77
Score = 34.7 bits (76), Expect = 3.1
Identities = 14/36 (38%), Positives = 17/36 (47%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C + GC H C+ C C G L +DGKTC
Sbjct: 288 CALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTC 323
Score = 33.1 bits (72), Expect = 9.3
Identities = 14/37 (37%), Positives = 19/37 (51%), Gaps = 3/37 (8%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTGM---PFEKSTT 1355
C ++N GC H C+ + Y C C G P EK+ T
Sbjct: 83 CASENHGCEHECVNADGSYLCQCHEGFALNPDEKTCT 119
>BC010444-1|AAH10444.1| 937|Homo sapiens matrilin 2 protein.
Length = 937
Score = 75.8 bits (178), Expect = 1e-12
Identities = 50/171 (29%), Positives = 76/171 (44%), Gaps = 16/171 (9%)
Query: 346 CSLDEYTCADRRCVL--KTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFR 403
CS E+ CA C+ +++C + D+ C + Q C ++H N +
Sbjct: 242 CSTLEHNCA-HFCINIPGSYVCRCKQGYILNSDQTTCRI-----QDLCAMEDH---NCEQ 292
Query: 404 NCVN--RKHVCDGMKDCPRGDDEERCPLKRKCSAEEK-CEKLCITTYDGHAACACPMGFL 460
CVN VC +D +RC C++E CE C+ DG C C GF
Sbjct: 293 LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNA-DGSYLCQCHEGFA 351
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCK 511
L D+ +C ID C + C C NT S+ C C+ G+ L PD+++C+
Sbjct: 352 LNPDEKTCTKIDYCA-SSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCR 401
Score = 72.5 bits (170), Expect = 1e-11
Identities = 65/263 (24%), Positives = 104/263 (39%), Gaps = 27/263 (10%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPG-SCNAGEFKCND-GKCIPE 319
RC +D+ C ++ C+ ++C + C G + N E C C
Sbjct: 317 RCVAVDY------CASENHGCE--HECVNADGSYLCQCHEGFALNPDEKTCTKIDYCASS 368
Query: 320 RWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEM 378
C +E C + D +C + D+ TC C L C+ +C N E+
Sbjct: 369 NHGCQHE--CVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCE--HECVNMEESY 424
Query: 379 NCEV----SCEEDQYTCRPQEHLMSNAF---RNCVNRKH--VCDGMKDCPRGDDEERCPL 429
C + + + TC +H + C+N + VC + +D + C
Sbjct: 425 YCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSR 484
Query: 430 KRKCS-AEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSN 488
C ++ CE C+ D AC CP G +L D +C +D C D C +C +
Sbjct: 485 VDYCLLSDHGCEYSCVNM-DRSFACQCPEGHVLRSDGKTCAKLDSCALG-DHGCEHSCVS 542
Query: 489 TVGSFRCGCMTGYILRPDERSCK 511
+ SF C C GYILR D ++C+
Sbjct: 543 SEDSFVCQCFEGYILREDGKTCR 565
Score = 68.1 bits (159), Expect = 3e-10
Identities = 68/237 (28%), Positives = 95/237 (40%), Gaps = 39/237 (16%)
Query: 310 KCNDGKCI-PERWRCDNERDCA--DGGDE---LNCKPNSIRNCSLDEYTCADRRCVLKTW 363
+C+ G + P C CA D G E LN + + + CS D LKT
Sbjct: 427 RCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINED----LKT- 481
Query: 364 LCDGVRDCTNGEDEMNCEVSCE--EDQYTCR-PQEHLMSNAFRNCVNR----------KH 410
C V C + CE SC + + C+ P+ H++ + + C +H
Sbjct: 482 -CSRVDYCLLSDH--GCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEH 538
Query: 411 VCDGMKD-----CPRG----DDEERCPLKRKCSA-EEKCEKLCITTYDGHAACACPMGFL 460
C +D C G +D + C K C A + CE +C+ + D + C C GF
Sbjct: 539 SCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYT-CECLEGFR 597
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESP 517
LAED CR D C C C N S+ C C G++L D R CK E P
Sbjct: 598 LAEDGKRCRRKDVCKSTHHG-CEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGP 653
Score = 39.9 bits (89), Expect = 0.081
Identities = 16/36 (44%), Positives = 17/36 (47%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C N GC H C+ G C C G LN D KTC
Sbjct: 324 CASENHGCEHECVNADGSYLCQCHEGFALNPDEKTC 359
Score = 39.9 bits (89), Expect = 0.081
Identities = 22/57 (38%), Positives = 25/57 (43%), Gaps = 2/57 (3%)
Query: 1005 AANKDTGAKRRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINY 1061
A N D + C +N GC H C+ SC C G LN D KTC INY
Sbjct: 351 ALNPDEKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCR--RINY 405
Score = 38.7 bits (86), Expect = 0.19
Identities = 20/54 (37%), Positives = 27/54 (50%), Gaps = 4/54 (7%)
Query: 1014 RRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDG---KTCADGPINYLIF 1064
RR C + GC H+C+ C C G L +DG K C +GPI+ L+F
Sbjct: 606 RRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPID-LVF 658
Score = 38.3 bits (85), Expect = 0.25
Identities = 18/49 (36%), Positives = 22/49 (44%)
Query: 1007 NKDTGAKRRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCA 1055
N D RR C N GC H C+ C C G L+ +GKTC+
Sbjct: 394 NPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCS 442
Score = 37.9 bits (84), Expect = 0.33
Identities = 18/49 (36%), Positives = 24/49 (48%)
Query: 1007 NKDTGAKRRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCA 1055
N+D R C ++ GC + C+ +C CP G L DGKTCA
Sbjct: 476 NEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCA 524
Score = 37.1 bits (82), Expect = 0.57
Identities = 11/25 (44%), Positives = 17/25 (68%)
Query: 1631 CKESNGGCSHLCLFRGHEYICACPD 1655
CK ++ GC H+C+ G+ YIC C +
Sbjct: 611 CKSTHHGCEHICVNNGNSYICKCSE 635
Score = 36.7 bits (81), Expect = 0.76
Identities = 18/59 (30%), Positives = 30/59 (50%), Gaps = 3/59 (5%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINY-LIFAHRVDIRVISLD 1076
C + + GC LCL C C G +N+D KTC+ ++Y L+ H + +++D
Sbjct: 447 CAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCS--RVDYCLLSDHGCEYSCVNMD 503
Score = 36.7 bits (81), Expect = 0.76
Identities = 18/59 (30%), Positives = 29/59 (49%), Gaps = 3/59 (5%)
Query: 1319 ENACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGS 1377
++ C + + GC H+C+ + Y C C G F + + KKC P + L+F GS
Sbjct: 608 KDVCKSTHHGCEHICVNNGNSYICKCSEG--FVLAEDGRRCKKCTEGPID-LVFVIDGS 663
Score = 36.3 bits (80), Expect = 1.00
Identities = 15/41 (36%), Positives = 21/41 (51%)
Query: 1014 RRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
RR C + GC H+C+ +C C G +L +DGK C
Sbjct: 565 RRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRC 605
Score = 35.1 bits (77), Expect = 2.3
Identities = 14/36 (38%), Positives = 16/36 (44%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C C+H C+ PG C C G LN D TC
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTC 277
Score = 35.1 bits (77), Expect = 2.3
Identities = 14/36 (38%), Positives = 17/36 (47%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C + C LC+ PG C C G L +DGK C
Sbjct: 283 CAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRC 318
Score = 34.7 bits (76), Expect = 3.1
Identities = 14/36 (38%), Positives = 17/36 (47%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C + GC H C+ C C G L +DGKTC
Sbjct: 529 CALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTC 564
Score = 33.1 bits (72), Expect = 9.3
Identities = 14/37 (37%), Positives = 19/37 (51%), Gaps = 3/37 (8%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTGM---PFEKSTT 1355
C ++N GC H C+ + Y C C G P EK+ T
Sbjct: 324 CASENHGCEHECVNADGSYLCQCHEGFALNPDEKTCT 360
>AL833931-1|CAD38787.1| 1016|Homo sapiens hypothetical protein
protein.
Length = 1016
Score = 75.8 bits (178), Expect = 1e-12
Identities = 50/171 (29%), Positives = 76/171 (44%), Gaps = 16/171 (9%)
Query: 346 CSLDEYTCADRRCVL--KTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFR 403
CS E+ CA C+ +++C + D+ C + Q C ++H N +
Sbjct: 302 CSTLEHNCA-HFCINIPGSYVCRCKQGYILNSDQTTCRI-----QDLCAMEDH---NCEQ 352
Query: 404 NCVN--RKHVCDGMKDCPRGDDEERCPLKRKCSAEEK-CEKLCITTYDGHAACACPMGFL 460
CVN VC +D +RC C++E CE C+ DG C C GF
Sbjct: 353 LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNA-DGSYLCQCHEGFA 411
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCK 511
L D+ +C ID C + C C NT S+ C C+ G+ L PD+++C+
Sbjct: 412 LNPDEKTCTKIDYCA-SSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCR 461
Score = 72.5 bits (170), Expect = 1e-11
Identities = 65/263 (24%), Positives = 104/263 (39%), Gaps = 27/263 (10%)
Query: 262 RCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPG-SCNAGEFKCND-GKCIPE 319
RC +D+ C ++ C+ ++C + C G + N E C C
Sbjct: 377 RCVAVDY------CASENHGCE--HECVNADGSYLCQCHEGFALNPDEKTCTKIDYCASS 428
Query: 320 RWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEM 378
C +E C + D +C + D+ TC C L C+ +C N E+
Sbjct: 429 NHGCQHE--CVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCE--HECVNMEESY 484
Query: 379 NCEV----SCEEDQYTCRPQEHLMSNAF---RNCVNRKH--VCDGMKDCPRGDDEERCPL 429
C + + + TC +H + C+N + VC + +D + C
Sbjct: 485 YCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSR 544
Query: 430 KRKCS-AEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSN 488
C ++ CE C+ D AC CP G +L D +C +D C D C +C +
Sbjct: 545 VDYCLLSDHGCEYSCVNM-DRSFACQCPEGHVLRSDGKTCAKLDSCALG-DHGCEHSCVS 602
Query: 489 TVGSFRCGCMTGYILRPDERSCK 511
+ SF C C GYILR D ++C+
Sbjct: 603 SEDSFVCQCFEGYILREDGKTCR 625
Score = 68.1 bits (159), Expect = 3e-10
Identities = 68/237 (28%), Positives = 95/237 (40%), Gaps = 39/237 (16%)
Query: 310 KCNDGKCI-PERWRCDNERDCA--DGGDE---LNCKPNSIRNCSLDEYTCADRRCVLKTW 363
+C+ G + P C CA D G E LN + + + CS D LKT
Sbjct: 487 RCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINED----LKT- 541
Query: 364 LCDGVRDCTNGEDEMNCEVSCE--EDQYTCR-PQEHLMSNAFRNCVNR----------KH 410
C V C + CE SC + + C+ P+ H++ + + C +H
Sbjct: 542 -CSRVDYCLLSDH--GCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEH 598
Query: 411 VCDGMKD-----CPRG----DDEERCPLKRKCSA-EEKCEKLCITTYDGHAACACPMGFL 460
C +D C G +D + C K C A + CE +C+ + D + C C GF
Sbjct: 599 SCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYT-CECLEGFR 657
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESP 517
LAED CR D C C C N S+ C C G++L D R CK E P
Sbjct: 658 LAEDGKRCRRKDVCKSTHHG-CEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGP 713
Score = 39.9 bits (89), Expect = 0.081
Identities = 16/36 (44%), Positives = 17/36 (47%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C N GC H C+ G C C G LN D KTC
Sbjct: 384 CASENHGCEHECVNADGSYLCQCHEGFALNPDEKTC 419
Score = 39.9 bits (89), Expect = 0.081
Identities = 22/57 (38%), Positives = 25/57 (43%), Gaps = 2/57 (3%)
Query: 1005 AANKDTGAKRRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINY 1061
A N D + C +N GC H C+ SC C G LN D KTC INY
Sbjct: 411 ALNPDEKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCR--RINY 465
Score = 38.7 bits (86), Expect = 0.19
Identities = 20/54 (37%), Positives = 27/54 (50%), Gaps = 4/54 (7%)
Query: 1014 RRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDG---KTCADGPINYLIF 1064
RR C + GC H+C+ C C G L +DG K C +GPI+ L+F
Sbjct: 666 RRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPID-LVF 718
Score = 38.3 bits (85), Expect = 0.25
Identities = 18/49 (36%), Positives = 22/49 (44%)
Query: 1007 NKDTGAKRRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCA 1055
N D RR C N GC H C+ C C G L+ +GKTC+
Sbjct: 454 NPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCS 502
Score = 37.9 bits (84), Expect = 0.33
Identities = 18/49 (36%), Positives = 24/49 (48%)
Query: 1007 NKDTGAKRRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCA 1055
N+D R C ++ GC + C+ +C CP G L DGKTCA
Sbjct: 536 NEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCA 584
Score = 37.1 bits (82), Expect = 0.57
Identities = 11/25 (44%), Positives = 17/25 (68%)
Query: 1631 CKESNGGCSHLCLFRGHEYICACPD 1655
CK ++ GC H+C+ G+ YIC C +
Sbjct: 671 CKSTHHGCEHICVNNGNSYICKCSE 695
Score = 36.7 bits (81), Expect = 0.76
Identities = 18/59 (30%), Positives = 30/59 (50%), Gaps = 3/59 (5%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINY-LIFAHRVDIRVISLD 1076
C + + GC LCL C C G +N+D KTC+ ++Y L+ H + +++D
Sbjct: 507 CAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCS--RVDYCLLSDHGCEYSCVNMD 563
Score = 36.7 bits (81), Expect = 0.76
Identities = 18/59 (30%), Positives = 29/59 (49%), Gaps = 3/59 (5%)
Query: 1319 ENACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGS 1377
++ C + + GC H+C+ + Y C C G F + + KKC P + L+F GS
Sbjct: 668 KDVCKSTHHGCEHICVNNGNSYICKCSEG--FVLAEDGRRCKKCTEGPID-LVFVIDGS 723
Score = 36.3 bits (80), Expect = 1.00
Identities = 15/41 (36%), Positives = 21/41 (51%)
Query: 1014 RRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
RR C + GC H+C+ +C C G +L +DGK C
Sbjct: 625 RRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRC 665
Score = 35.1 bits (77), Expect = 2.3
Identities = 14/36 (38%), Positives = 16/36 (44%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C C+H C+ PG C C G LN D TC
Sbjct: 302 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTC 337
Score = 35.1 bits (77), Expect = 2.3
Identities = 14/36 (38%), Positives = 17/36 (47%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C + C LC+ PG C C G L +DGK C
Sbjct: 343 CAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRC 378
Score = 34.7 bits (76), Expect = 3.1
Identities = 14/36 (38%), Positives = 17/36 (47%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C + GC H C+ C C G L +DGKTC
Sbjct: 589 CALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTC 624
Score = 33.1 bits (72), Expect = 9.3
Identities = 14/37 (37%), Positives = 19/37 (51%), Gaps = 3/37 (8%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTGM---PFEKSTT 1355
C ++N GC H C+ + Y C C G P EK+ T
Sbjct: 384 CASENHGCEHECVNADGSYLCQCHEGFALNPDEKTCT 420
>AL021391-3|CAI18930.1| 703|Homo sapiens fibulin 1 protein.
Length = 703
Score = 75.8 bits (178), Expect = 1e-12
Identities = 60/243 (24%), Positives = 93/243 (38%), Gaps = 21/243 (8%)
Query: 282 CDGDNDCGDWTDEDSCPMVPGSCNA-GEFKCN-DGKC-----IPERWRCDNERDCADGGD 334
C+ N+C T SC + N G F+C D C + E C + +C G
Sbjct: 214 CEDVNEC--ITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIH 271
Query: 335 ELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ 394
NC P+ I +L + C + ++ D + +C + + ++ C +TC
Sbjct: 272 --NCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIG-HTCINT 328
Query: 395 E--HLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAA 452
E + NC H+ + C D +E P C +C G
Sbjct: 329 EGSYTCQKNVPNCGRGYHLNEEGTRCV--DVDECAPPAEPCGKGHRC-----VNSPGSFR 381
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP 512
C C G+ C D++EC +C C NT+GS+ C C G+ L D RSC+
Sbjct: 382 CECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCED 441
Query: 513 TGE 515
E
Sbjct: 442 INE 444
Score = 68.5 bits (160), Expect = 2e-10
Identities = 74/280 (26%), Positives = 102/280 (36%), Gaps = 32/280 (11%)
Query: 263 CAEIDFECKNT--KCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND-GKCIPE 319
C +ID EC++ C+P DF C N G + G C D +C+
Sbjct: 260 CKDID-ECESGIHNCLP-DFICQ--NTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSI 315
Query: 320 RWRCDNERDCADGGDELNCK---PNSIRNCSLDEY--TCAD-RRCVLKTWLCDGVRDCTN 373
C C + C+ PN R L+E C D C C C N
Sbjct: 316 SAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVN 375
Query: 374 GEDEMNCEVSCEEDQY------TCRPQEHLMSNAFRNCVNR------KHVCDGMKDCPRG 421
CE C+ Y C R C ++ ++C
Sbjct: 376 SPGSFRCE--CKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLS 433
Query: 422 DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAE-DKYSCRDIDECMYEQDP 480
D C +CS+ C + C Y G C C G+ L++ D +C DIDEC
Sbjct: 434 VDGRSCEDINECSSSP-CSQECANVY-GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGG 491
Query: 481 -VCSQTCSNTVGSFRCGC-MTGYILRPDERSCKPTGESPT 518
+CS C N GSF+C C +GY L P+ R+C+ E T
Sbjct: 492 HICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVT 531
Score = 67.7 bits (158), Expect = 4e-10
Identities = 70/262 (26%), Positives = 104/262 (39%), Gaps = 43/262 (16%)
Query: 280 FQCDGDNDCG---DWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDEL 336
F+C D+ CG + T+++SC + C +G C +P+ + C N +L
Sbjct: 240 FRCQRDSSCGTGYELTEDNSCKDID-ECESGIHNC-----LPD-FICQNTLGSFRCRPKL 292
Query: 337 NCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQE 395
CK I++ + C D C+ + C C N E +C+++ C
Sbjct: 293 QCKSGFIQDALGN---CIDINECLSISAPCPIGHTCINTEGSY----TCQKNVPNCGRGY 345
Query: 396 HLMSNAFR-----NCVNRKHVCDGMKDCPRGDDEERCPLK---------RKCSAEEKCEK 441
HL R C C C RC K R C +C++
Sbjct: 346 HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQR 405
Query: 442 ----LCITTYD---GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFR 494
LC + G C+C +GF L+ D SC DI+EC P CSQ C+N GS++
Sbjct: 406 YPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSSP-CSQECANVYGSYQ 462
Query: 495 CGCMTGYILRP-DERSCKPTGE 515
C C GY L D +C+ E
Sbjct: 463 CYCRRGYQLSDVDGVTCEDIDE 484
Score = 62.9 bits (146), Expect = 1e-08
Identities = 37/100 (37%), Positives = 51/100 (51%), Gaps = 8/100 (8%)
Query: 422 DDEERCP-LKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP 480
++E+ P L +C C++ C T D C+C +G+ L D SC D++EC+
Sbjct: 168 EEEQEDPYLNDRCRGGGPCKQQCRDTGD-EVVCSCFVGYQLLSDGVSCEDVNECITGSHS 226
Query: 481 V-CSQTCSNTVGSFRC----GCMTGYILRPDERSCKPTGE 515
++C NTVGSFRC C TGY L D SCK E
Sbjct: 227 CRLGESCINTVGSFRCQRDSSCGTGYELTED-NSCKDIDE 265
Score = 44.4 bits (100), Expect = 0.004
Identities = 50/207 (24%), Positives = 78/207 (37%), Gaps = 15/207 (7%)
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYT 352
D D C C G +C + P +RC+ + G C + C
Sbjct: 356 DVDECAPPAEPCGKGH-RCVNS---PGSFRCECKTGYYFDGISRMCV--DVNECQRYPGR 409
Query: 353 CADRRC--VLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKH 410
+C L ++LC D +CE E C + + +++ C R+
Sbjct: 410 LCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQ-CYCRRG 468
Query: 411 VCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPM-GFLLAEDKYSCR 469
D +D + C L + C CI G C+CP G+ LA + +C+
Sbjct: 469 YQLSDVDGVTCEDIDECALP---TGGHICSYRCINI-PGSFQCSCPSSGYRLAPNGRNCQ 524
Query: 470 DIDECMYE-QDPVCSQTCSNTVGSFRC 495
DIDEC+ + ++TC N G FRC
Sbjct: 525 DIDECVTGIHNCSINETCFNIQGGFRC 551
Score = 35.1 bits (77), Expect = 2.3
Identities = 12/31 (38%), Positives = 18/31 (58%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C H C G C+C +G +L+ DG++C D
Sbjct: 411 CGHKCENTLGSYLCSCSVGFRLSVDGRSCED 441
Score = 34.7 bits (76), Expect = 3.1
Identities = 16/41 (39%), Positives = 22/41 (53%), Gaps = 3/41 (7%)
Query: 1019 CGKNNGG--CSHLCLLKPGGRSCACP-IGIKLNKDGKTCAD 1056
C GG CS+ C+ PG C+CP G +L +G+ C D
Sbjct: 485 CALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQD 525
Score = 34.3 bits (75), Expect = 4.0
Identities = 17/45 (37%), Positives = 20/45 (44%)
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIG 526
C Q C +T C C GY L D SC+ E T S R+G
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLG 230
>AK075566-1|BAC11705.1| 638|Homo sapiens protein ( Homo sapiens
cDNA PSEC0266 fis, clone NT2RP3003649, highly similar to
Homo sapiens fibulin-1D mRNA. ).
Length = 638
Score = 75.8 bits (178), Expect = 1e-12
Identities = 60/243 (24%), Positives = 93/243 (38%), Gaps = 21/243 (8%)
Query: 282 CDGDNDCGDWTDEDSCPMVPGSCNA-GEFKCN-DGKC-----IPERWRCDNERDCADGGD 334
C+ N+C T SC + N G F+C D C + E C + +C G
Sbjct: 149 CEDVNEC--ITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIH 206
Query: 335 ELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ 394
NC P+ I +L + C + ++ D + +C + + ++ C +TC
Sbjct: 207 --NCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIG-HTCINT 263
Query: 395 E--HLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAA 452
E + NC H+ + C D +E P C +C G
Sbjct: 264 EGSYTCQKNVPNCGRGYHLNEEGTRCV--DVDECAPPAEPCGKGHRC-----VNSPGSFR 316
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP 512
C C G+ C D++EC +C C NT+GS+ C C G+ L D RSC+
Sbjct: 317 CECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCED 376
Query: 513 TGE 515
E
Sbjct: 377 INE 379
Score = 68.5 bits (160), Expect = 2e-10
Identities = 74/280 (26%), Positives = 102/280 (36%), Gaps = 32/280 (11%)
Query: 263 CAEIDFECKNT--KCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND-GKCIPE 319
C +ID EC++ C+P DF C N G + G C D +C+
Sbjct: 195 CKDID-ECESGIHNCLP-DFICQ--NTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSI 250
Query: 320 RWRCDNERDCADGGDELNCK---PNSIRNCSLDEY--TCAD-RRCVLKTWLCDGVRDCTN 373
C C + C+ PN R L+E C D C C C N
Sbjct: 251 SAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVN 310
Query: 374 GEDEMNCEVSCEEDQY------TCRPQEHLMSNAFRNCVNR------KHVCDGMKDCPRG 421
CE C+ Y C R C ++ ++C
Sbjct: 311 SPGSFRCE--CKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLS 368
Query: 422 DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAE-DKYSCRDIDECMYEQDP 480
D C +CS+ C + C Y G C C G+ L++ D +C DIDEC
Sbjct: 369 VDGRSCEDINECSSSP-CSQECANVY-GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGG 426
Query: 481 -VCSQTCSNTVGSFRCGC-MTGYILRPDERSCKPTGESPT 518
+CS C N GSF+C C +GY L P+ R+C+ E T
Sbjct: 427 HICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVT 466
Score = 67.7 bits (158), Expect = 4e-10
Identities = 70/262 (26%), Positives = 104/262 (39%), Gaps = 43/262 (16%)
Query: 280 FQCDGDNDCG---DWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDEL 336
F+C D+ CG + T+++SC + C +G C +P+ + C N +L
Sbjct: 175 FRCQRDSSCGTGYELTEDNSCKDID-ECESGIHNC-----LPD-FICQNTLGSFRCRPKL 227
Query: 337 NCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQE 395
CK I++ + C D C+ + C C N E +C+++ C
Sbjct: 228 QCKSGFIQDALGN---CIDINECLSISAPCPIGHTCINTEGSY----TCQKNVPNCGRGY 280
Query: 396 HLMSNAFR-----NCVNRKHVCDGMKDCPRGDDEERCPLK---------RKCSAEEKCEK 441
HL R C C C RC K R C +C++
Sbjct: 281 HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQR 340
Query: 442 ----LCITTYD---GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFR 494
LC + G C+C +GF L+ D SC DI+EC P CSQ C+N GS++
Sbjct: 341 YPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSSP-CSQECANVYGSYQ 397
Query: 495 CGCMTGYILRP-DERSCKPTGE 515
C C GY L D +C+ E
Sbjct: 398 CYCRRGYQLSDVDGVTCEDIDE 419
Score = 62.9 bits (146), Expect = 1e-08
Identities = 37/100 (37%), Positives = 51/100 (51%), Gaps = 8/100 (8%)
Query: 422 DDEERCP-LKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP 480
++E+ P L +C C++ C T D C+C +G+ L D SC D++EC+
Sbjct: 103 EEEQEDPYLNDRCRGGGPCKQQCRDTGD-EVVCSCFVGYQLLSDGVSCEDVNECITGSHS 161
Query: 481 V-CSQTCSNTVGSFRC----GCMTGYILRPDERSCKPTGE 515
++C NTVGSFRC C TGY L D SCK E
Sbjct: 162 CRLGESCINTVGSFRCQRDSSCGTGYELTED-NSCKDIDE 200
Score = 44.4 bits (100), Expect = 0.004
Identities = 50/207 (24%), Positives = 78/207 (37%), Gaps = 15/207 (7%)
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYT 352
D D C C G +C + P +RC+ + G C + C
Sbjct: 291 DVDECAPPAEPCGKGH-RCVNS---PGSFRCECKTGYYFDGISRMCV--DVNECQRYPGR 344
Query: 353 CADRRC--VLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKH 410
+C L ++LC D +CE E C + + +++ C R+
Sbjct: 345 LCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQ-CYCRRG 403
Query: 411 VCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPM-GFLLAEDKYSCR 469
D +D + C L + C CI G C+CP G+ LA + +C+
Sbjct: 404 YQLSDVDGVTCEDIDECALP---TGGHICSYRCINI-PGSFQCSCPSSGYRLAPNGRNCQ 459
Query: 470 DIDECMYE-QDPVCSQTCSNTVGSFRC 495
DIDEC+ + ++TC N G FRC
Sbjct: 460 DIDECVTGIHNCSINETCFNIQGGFRC 486
Score = 35.1 bits (77), Expect = 2.3
Identities = 12/31 (38%), Positives = 18/31 (58%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C H C G C+C +G +L+ DG++C D
Sbjct: 346 CGHKCENTLGSYLCSCSVGFRLSVDGRSCED 376
Score = 34.7 bits (76), Expect = 3.1
Identities = 16/41 (39%), Positives = 22/41 (53%), Gaps = 3/41 (7%)
Query: 1019 CGKNNGG--CSHLCLLKPGGRSCACP-IGIKLNKDGKTCAD 1056
C GG CS+ C+ PG C+CP G +L +G+ C D
Sbjct: 420 CALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQD 460
Score = 34.3 bits (75), Expect = 4.0
Identities = 17/45 (37%), Positives = 20/45 (44%)
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIG 526
C Q C +T C C GY L D SC+ E T S R+G
Sbjct: 121 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLG 165
>AF217999-1|AAG17241.1| 495|Homo sapiens unknown protein.
Length = 495
Score = 75.8 bits (178), Expect = 1e-12
Identities = 60/243 (24%), Positives = 93/243 (38%), Gaps = 21/243 (8%)
Query: 282 CDGDNDCGDWTDEDSCPMVPGSCNA-GEFKCN-DGKC-----IPERWRCDNERDCADGGD 334
C+ N+C T SC + N G F+C D C + E C + +C G
Sbjct: 84 CEDVNEC--ITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIH 141
Query: 335 ELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ 394
NC P+ I +L + C + ++ D + +C + + ++ C +TC
Sbjct: 142 --NCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIG-HTCINT 198
Query: 395 E--HLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAA 452
E + NC H+ + C D +E P C +C G
Sbjct: 199 EGSYTCQKNVPNCGRGYHLNEEGTRCV--DVDECAPPAEPCGKGHRC-----VNSPGSFR 251
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP 512
C C G+ C D++EC +C C NT+GS+ C C G+ L D RSC+
Sbjct: 252 CECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCED 311
Query: 513 TGE 515
E
Sbjct: 312 INE 314
Score = 68.5 bits (160), Expect = 2e-10
Identities = 74/280 (26%), Positives = 102/280 (36%), Gaps = 32/280 (11%)
Query: 263 CAEIDFECKNT--KCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND-GKCIPE 319
C +ID EC++ C+P DF C N G + G C D +C+
Sbjct: 130 CKDID-ECESGIHNCLP-DFICQ--NTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSI 185
Query: 320 RWRCDNERDCADGGDELNCK---PNSIRNCSLDEY--TCAD-RRCVLKTWLCDGVRDCTN 373
C C + C+ PN R L+E C D C C C N
Sbjct: 186 SAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVN 245
Query: 374 GEDEMNCEVSCEEDQY------TCRPQEHLMSNAFRNCVNR------KHVCDGMKDCPRG 421
CE C+ Y C R C ++ ++C
Sbjct: 246 SPGSFRCE--CKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLS 303
Query: 422 DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAE-DKYSCRDIDECMYEQDP 480
D C +CS+ C + C Y G C C G+ L++ D +C DIDEC
Sbjct: 304 VDGRSCEDINECSSSP-CSQECANVY-GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGG 361
Query: 481 -VCSQTCSNTVGSFRCGC-MTGYILRPDERSCKPTGESPT 518
+CS C N GSF+C C +GY L P+ R+C+ E T
Sbjct: 362 HICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVT 401
Score = 67.7 bits (158), Expect = 4e-10
Identities = 70/262 (26%), Positives = 104/262 (39%), Gaps = 43/262 (16%)
Query: 280 FQCDGDNDCG---DWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDEL 336
F+C D+ CG + T+++SC + C +G C +P+ + C N +L
Sbjct: 110 FRCQRDSSCGTGYELTEDNSCKDID-ECESGIHNC-----LPD-FICQNTLGSFRCRPKL 162
Query: 337 NCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQE 395
CK I++ + C D C+ + C C N E +C+++ C
Sbjct: 163 QCKSGFIQDALGN---CIDINECLSISAPCPIGHTCINTEGSY----TCQKNVPNCGRGY 215
Query: 396 HLMSNAFR-----NCVNRKHVCDGMKDCPRGDDEERCPLK---------RKCSAEEKCEK 441
HL R C C C RC K R C +C++
Sbjct: 216 HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQR 275
Query: 442 ----LCITTYD---GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFR 494
LC + G C+C +GF L+ D SC DI+EC P CSQ C+N GS++
Sbjct: 276 YPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSSP-CSQECANVYGSYQ 332
Query: 495 CGCMTGYILRP-DERSCKPTGE 515
C C GY L D +C+ E
Sbjct: 333 CYCRRGYQLSDVDGVTCEDIDE 354
Score = 62.9 bits (146), Expect = 1e-08
Identities = 37/100 (37%), Positives = 51/100 (51%), Gaps = 8/100 (8%)
Query: 422 DDEERCP-LKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP 480
++E+ P L +C C++ C T D C+C +G+ L D SC D++EC+
Sbjct: 38 EEEQEDPYLNDRCRGGGPCKQQCRDTGD-EVVCSCFVGYQLLSDGVSCEDVNECITGSHS 96
Query: 481 V-CSQTCSNTVGSFRC----GCMTGYILRPDERSCKPTGE 515
++C NTVGSFRC C TGY L D SCK E
Sbjct: 97 CRLGESCINTVGSFRCQRDSSCGTGYELTED-NSCKDIDE 135
Score = 44.4 bits (100), Expect = 0.004
Identities = 50/207 (24%), Positives = 78/207 (37%), Gaps = 15/207 (7%)
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYT 352
D D C C G +C + P +RC+ + G C + C
Sbjct: 226 DVDECAPPAEPCGKGH-RCVNS---PGSFRCECKTGYYFDGISRMCV--DVNECQRYPGR 279
Query: 353 CADRRC--VLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKH 410
+C L ++LC D +CE E C + + +++ C R+
Sbjct: 280 LCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQ-CYCRRG 338
Query: 411 VCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPM-GFLLAEDKYSCR 469
D +D + C L + C CI G C+CP G+ LA + +C+
Sbjct: 339 YQLSDVDGVTCEDIDECALP---TGGHICSYRCINI-PGSFQCSCPSSGYRLAPNGRNCQ 394
Query: 470 DIDECMYE-QDPVCSQTCSNTVGSFRC 495
DIDEC+ + ++TC N G FRC
Sbjct: 395 DIDECVTGIHNCSINETCFNIQGGFRC 421
Score = 35.1 bits (77), Expect = 2.3
Identities = 12/31 (38%), Positives = 18/31 (58%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C H C G C+C +G +L+ DG++C D
Sbjct: 281 CGHKCENTLGSYLCSCSVGFRLSVDGRSCED 311
Score = 34.7 bits (76), Expect = 3.1
Identities = 16/41 (39%), Positives = 22/41 (53%), Gaps = 3/41 (7%)
Query: 1019 CGKNNGG--CSHLCLLKPGGRSCACP-IGIKLNKDGKTCAD 1056
C GG CS+ C+ PG C+CP G +L +G+ C D
Sbjct: 355 CALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQD 395
Score = 34.3 bits (75), Expect = 4.0
Identities = 17/45 (37%), Positives = 20/45 (44%)
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIG 526
C Q C +T C C GY L D SC+ E T S R+G
Sbjct: 56 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLG 100
>AF126110-1|AAK37822.1| 703|Homo sapiens fibulin-1 isoform D
precursor protein.
Length = 703
Score = 75.8 bits (178), Expect = 1e-12
Identities = 60/243 (24%), Positives = 93/243 (38%), Gaps = 21/243 (8%)
Query: 282 CDGDNDCGDWTDEDSCPMVPGSCNA-GEFKCN-DGKC-----IPERWRCDNERDCADGGD 334
C+ N+C T SC + N G F+C D C + E C + +C G
Sbjct: 214 CEDVNEC--ITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIH 271
Query: 335 ELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ 394
NC P+ I +L + C + ++ D + +C + + ++ C +TC
Sbjct: 272 --NCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIG-HTCINT 328
Query: 395 E--HLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAA 452
E + NC H+ + C D +E P C +C G
Sbjct: 329 EGSYTCQKNVPNCGRGYHLNEEGTRCV--DVDECAPPAEPCGKGHRC-----VNSPGSFR 381
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP 512
C C G+ C D++EC +C C NT+GS+ C C G+ L D RSC+
Sbjct: 382 CECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCED 441
Query: 513 TGE 515
E
Sbjct: 442 INE 444
Score = 68.5 bits (160), Expect = 2e-10
Identities = 74/280 (26%), Positives = 102/280 (36%), Gaps = 32/280 (11%)
Query: 263 CAEIDFECKNT--KCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND-GKCIPE 319
C +ID EC++ C+P DF C N G + G C D +C+
Sbjct: 260 CKDID-ECESGIHNCLP-DFICQ--NTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSI 315
Query: 320 RWRCDNERDCADGGDELNCK---PNSIRNCSLDEY--TCAD-RRCVLKTWLCDGVRDCTN 373
C C + C+ PN R L+E C D C C C N
Sbjct: 316 SAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVN 375
Query: 374 GEDEMNCEVSCEEDQY------TCRPQEHLMSNAFRNCVNR------KHVCDGMKDCPRG 421
CE C+ Y C R C ++ ++C
Sbjct: 376 SPGSFRCE--CKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLS 433
Query: 422 DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAE-DKYSCRDIDECMYEQDP 480
D C +CS+ C + C Y G C C G+ L++ D +C DIDEC
Sbjct: 434 VDGRSCEDINECSSSP-CSQECANVY-GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGG 491
Query: 481 -VCSQTCSNTVGSFRCGC-MTGYILRPDERSCKPTGESPT 518
+CS C N GSF+C C +GY L P+ R+C+ E T
Sbjct: 492 HICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVT 531
Score = 67.7 bits (158), Expect = 4e-10
Identities = 70/262 (26%), Positives = 104/262 (39%), Gaps = 43/262 (16%)
Query: 280 FQCDGDNDCG---DWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDEL 336
F+C D+ CG + T+++SC + C +G C +P+ + C N +L
Sbjct: 240 FRCQRDSSCGTGYELTEDNSCKDID-ECESGIHNC-----LPD-FICQNTLGSFRCRPKL 292
Query: 337 NCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQE 395
CK I++ + C D C+ + C C N E +C+++ C
Sbjct: 293 QCKSGFIQDALGN---CIDINECLSISAPCPIGHTCINTEGSY----TCQKNVPNCGRGY 345
Query: 396 HLMSNAFR-----NCVNRKHVCDGMKDCPRGDDEERCPLK---------RKCSAEEKCEK 441
HL R C C C RC K R C +C++
Sbjct: 346 HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQR 405
Query: 442 ----LCITTYD---GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFR 494
LC + G C+C +GF L+ D SC DI+EC P CSQ C+N GS++
Sbjct: 406 YPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSSP-CSQECANVYGSYQ 462
Query: 495 CGCMTGYILRP-DERSCKPTGE 515
C C GY L D +C+ E
Sbjct: 463 CYCRRGYQLSDVDGVTCEDIDE 484
Score = 62.9 bits (146), Expect = 1e-08
Identities = 37/100 (37%), Positives = 51/100 (51%), Gaps = 8/100 (8%)
Query: 422 DDEERCP-LKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP 480
++E+ P L +C C++ C T D C+C +G+ L D SC D++EC+
Sbjct: 168 EEEQEDPYLNDRCRGGGPCKQQCRDTGD-EVVCSCFVGYQLLSDGVSCEDVNECITGSHS 226
Query: 481 V-CSQTCSNTVGSFRC----GCMTGYILRPDERSCKPTGE 515
++C NTVGSFRC C TGY L D SCK E
Sbjct: 227 CRLGESCINTVGSFRCQRDSSCGTGYELTED-NSCKDIDE 265
Score = 44.8 bits (101), Expect = 0.003
Identities = 50/207 (24%), Positives = 79/207 (38%), Gaps = 15/207 (7%)
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYT 352
D D C C G +C + P +RC+ + G C + C
Sbjct: 356 DVDECAPPAEPCGKGH-RCVNS---PGSFRCECKTGYYFDGISRMCV--DVNECQRYPGR 409
Query: 353 CADRRC--VLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKH 410
+C L ++LC D +CE E C + + +++ C R+
Sbjct: 410 LCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQ-CYCRRG 468
Query: 411 VCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPM-GFLLAEDKYSCR 469
D +D + C L + C CI G C+CP G+ LA + +C+
Sbjct: 469 YQLSDVDGVTCEDIDECALP---TGGHICSYRCINI-PGSFQCSCPSSGYRLAPNGRNCQ 524
Query: 470 DIDECMYE-QDPVCSQTCSNTVGSFRC 495
DIDEC+ + ++TC N G+FRC
Sbjct: 525 DIDECVTGIHNCSINETCFNIQGAFRC 551
Score = 35.1 bits (77), Expect = 2.3
Identities = 12/31 (38%), Positives = 18/31 (58%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C H C G C+C +G +L+ DG++C D
Sbjct: 411 CGHKCENTLGSYLCSCSVGFRLSVDGRSCED 441
Score = 34.7 bits (76), Expect = 3.1
Identities = 16/41 (39%), Positives = 22/41 (53%), Gaps = 3/41 (7%)
Query: 1019 CGKNNGG--CSHLCLLKPGGRSCACP-IGIKLNKDGKTCAD 1056
C GG CS+ C+ PG C+CP G +L +G+ C D
Sbjct: 485 CALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQD 525
Score = 34.3 bits (75), Expect = 4.0
Identities = 17/45 (37%), Positives = 20/45 (44%)
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTLLFSNRIG 526
C Q C +T C C GY L D SC+ E T S R+G
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLG 230
>AL513320-1|CAI14334.1| 1229|Homo sapiens multiple EGF-like-domains
6 protein.
Length = 1229
Score = 75.4 bits (177), Expect = 2e-12
Identities = 37/102 (36%), Positives = 48/102 (47%), Gaps = 6/102 (5%)
Query: 418 CPRG----DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDE 473
CPRG D+ C C+ C+++C T G C C G+ L+ D C D+DE
Sbjct: 252 CPRGYELDTDQRTCIDVDDCADSPCCQQVC-TNNPGGYECGCYAGYRLSADGCGCEDVDE 310
Query: 474 CMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C + C C+N GSF+C C GY L D R C P E
Sbjct: 311 CASSRGG-CEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEE 351
Score = 65.3 bits (152), Expect = 2e-09
Identities = 74/295 (25%), Positives = 108/295 (36%), Gaps = 38/295 (12%)
Query: 239 CAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCV--PKDFQCDGDNDCGDWTDEDS 296
C L A P S +Q ++ C + C++ +CV P + C+ TD +
Sbjct: 36 CYPCHLGQAGYPVSAGDQRPDVDECRTHNGGCQH-RCVNTPGSYLCECKPGFRLHTDSRT 94
Query: 297 CPMVPGSCNAGEFKCNDGKCIP---ERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTC 353
C + SC G C C+ R RC D +C S C+ +C
Sbjct: 95 CLAI-NSCALGNGGCQH-HCVQLTITRHRCQCRPGFQLQEDGRHCVRRS--PCANRNGSC 150
Query: 354 ADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHL---MSNAFRNCVNR-- 408
R C VR E + +++ D C + ++ C+N
Sbjct: 151 MHR--------CQVVRGLARCECHVGYQLAA--DGKACEDVDECAAGLAQCAHGCLNTQG 200
Query: 409 --KHVCDGMKDCPRGDDEERC-----PLKRKCSAEEK-CEKLCITTYDGHAACACPMGFL 460
K VC + G D +C + C A C C T G C CP G+
Sbjct: 201 SFKCVCHAGYEL--GADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAG-PLCTCPRGYE 257
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
L D+ +C D+D+C P C Q C+N G + CGC GY L D C+ E
Sbjct: 258 LDTDQRTCIDVDDC--ADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDE 310
Score = 47.6 bits (108), Expect = 4e-04
Identities = 19/38 (50%), Positives = 22/38 (57%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NNGGCSH C G C CP G +L+ D +TC D
Sbjct: 230 CEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCID 267
Score = 45.2 bits (102), Expect = 0.002
Identities = 16/36 (44%), Positives = 21/36 (58%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C +NGGC H C+ PG C C G +L+ D +TC
Sbjct: 60 CRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTC 95
Score = 42.3 bits (95), Expect = 0.015
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NG C H C + G C C +G +L DGK C D
Sbjct: 143 CANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACED 180
Score = 41.5 bits (93), Expect = 0.027
Identities = 18/44 (40%), Positives = 24/44 (54%), Gaps = 2/44 (4%)
Query: 1315 ERVLENACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQT 1358
E + N+C +NGGCSH C + G C CP G +E T +T
Sbjct: 223 EMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRG--YELDTDQRT 264
Score = 38.3 bits (85), Expect = 0.25
Identities = 13/26 (50%), Positives = 15/26 (57%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTG 1347
C T NGGC H C+ +P Y C C G
Sbjct: 60 CRTHNGGCQHRCVNTPGSYLCECKPG 85
Score = 38.3 bits (85), Expect = 0.25
Identities = 13/37 (35%), Positives = 20/37 (54%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCA 1055
C + GGC H C G C+C G +L++D + C+
Sbjct: 311 CASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCS 347
Score = 35.5 bits (78), Expect = 1.7
Identities = 15/37 (40%), Positives = 19/37 (51%), Gaps = 1/37 (2%)
Query: 1019 CGKNNGGCSHLCL-LKPGGRSCACPIGIKLNKDGKTC 1054
C NGGC H C+ L C C G +L +DG+ C
Sbjct: 101 CALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHC 137
Score = 35.5 bits (78), Expect = 1.7
Identities = 13/31 (41%), Positives = 16/31 (51%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C +C PGG C C G +L+ DG C D
Sbjct: 277 CQQVCTNNPGGYECGCYAGYRLSADGCGCED 307
Score = 34.3 bits (75), Expect = 4.0
Identities = 12/26 (46%), Positives = 15/26 (57%)
Query: 1629 NPCKESNGGCSHLCLFRGHEYICACP 1654
N C+ +NGGCSH C +C CP
Sbjct: 228 NSCEANNGGCSHGCSHTSAGPLCTCP 253
Score = 33.9 bits (74), Expect = 5.3
Identities = 13/36 (36%), Positives = 16/36 (44%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C C+H CL G C C G +L DG+ C
Sbjct: 184 CAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQC 219
Score = 33.5 bits (73), Expect = 7.0
Identities = 11/33 (33%), Positives = 18/33 (54%)
Query: 1621 SADRQHGWNPCKESNGGCSHLCLFRGHEYICAC 1653
+ D++ + C+ NGGC H C+ Y+C C
Sbjct: 50 AGDQRPDVDECRTHNGGCQHRCVNTPGSYLCEC 82
Score = 33.5 bits (73), Expect = 7.0
Identities = 16/46 (34%), Positives = 23/46 (50%), Gaps = 1/46 (2%)
Query: 434 SAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQD 479
S+ CE C T G C+C G+ L ED+ C ++E M + D
Sbjct: 313 SSRGGCEHHC-TNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLD 357
>AL512413-3|CAH70834.1| 1229|Homo sapiens multiple EGF-like-domains
6 protein.
Length = 1229
Score = 75.4 bits (177), Expect = 2e-12
Identities = 37/102 (36%), Positives = 48/102 (47%), Gaps = 6/102 (5%)
Query: 418 CPRG----DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDE 473
CPRG D+ C C+ C+++C T G C C G+ L+ D C D+DE
Sbjct: 252 CPRGYELDTDQRTCIDVDDCADSPCCQQVC-TNNPGGYECGCYAGYRLSADGCGCEDVDE 310
Query: 474 CMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C + C C+N GSF+C C GY L D R C P E
Sbjct: 311 CASSRGG-CEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEE 351
Score = 65.3 bits (152), Expect = 2e-09
Identities = 74/295 (25%), Positives = 108/295 (36%), Gaps = 38/295 (12%)
Query: 239 CAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCV--PKDFQCDGDNDCGDWTDEDS 296
C L A P S +Q ++ C + C++ +CV P + C+ TD +
Sbjct: 36 CYPCHLGQAGYPVSAGDQRPDVDECRTHNGGCQH-RCVNTPGSYLCECKPGFRLHTDSRT 94
Query: 297 CPMVPGSCNAGEFKCNDGKCIP---ERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTC 353
C + SC G C C+ R RC D +C S C+ +C
Sbjct: 95 CLAI-NSCALGNGGCQH-HCVQLTITRHRCQCRPGFQLQEDGRHCVRRS--PCANRNGSC 150
Query: 354 ADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHL---MSNAFRNCVNR-- 408
R C VR E + +++ D C + ++ C+N
Sbjct: 151 MHR--------CQVVRGLARCECHVGYQLAA--DGKACEDVDECAAGLAQCAHGCLNTQG 200
Query: 409 --KHVCDGMKDCPRGDDEERC-----PLKRKCSAEEK-CEKLCITTYDGHAACACPMGFL 460
K VC + G D +C + C A C C T G C CP G+
Sbjct: 201 SFKCVCHAGYEL--GADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAG-PLCTCPRGYE 257
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
L D+ +C D+D+C P C Q C+N G + CGC GY L D C+ E
Sbjct: 258 LDTDQRTCIDVDDC--ADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDE 310
Score = 47.6 bits (108), Expect = 4e-04
Identities = 19/38 (50%), Positives = 22/38 (57%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NNGGCSH C G C CP G +L+ D +TC D
Sbjct: 230 CEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCID 267
Score = 45.2 bits (102), Expect = 0.002
Identities = 16/36 (44%), Positives = 21/36 (58%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C +NGGC H C+ PG C C G +L+ D +TC
Sbjct: 60 CRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTC 95
Score = 42.3 bits (95), Expect = 0.015
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NG C H C + G C C +G +L DGK C D
Sbjct: 143 CANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACED 180
Score = 41.5 bits (93), Expect = 0.027
Identities = 18/44 (40%), Positives = 24/44 (54%), Gaps = 2/44 (4%)
Query: 1315 ERVLENACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQT 1358
E + N+C +NGGCSH C + G C CP G +E T +T
Sbjct: 223 EMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRG--YELDTDQRT 264
Score = 38.3 bits (85), Expect = 0.25
Identities = 13/26 (50%), Positives = 15/26 (57%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTG 1347
C T NGGC H C+ +P Y C C G
Sbjct: 60 CRTHNGGCQHRCVNTPGSYLCECKPG 85
Score = 38.3 bits (85), Expect = 0.25
Identities = 13/37 (35%), Positives = 20/37 (54%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCA 1055
C + GGC H C G C+C G +L++D + C+
Sbjct: 311 CASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCS 347
Score = 35.5 bits (78), Expect = 1.7
Identities = 15/37 (40%), Positives = 19/37 (51%), Gaps = 1/37 (2%)
Query: 1019 CGKNNGGCSHLCL-LKPGGRSCACPIGIKLNKDGKTC 1054
C NGGC H C+ L C C G +L +DG+ C
Sbjct: 101 CALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHC 137
Score = 35.5 bits (78), Expect = 1.7
Identities = 13/31 (41%), Positives = 16/31 (51%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C +C PGG C C G +L+ DG C D
Sbjct: 277 CQQVCTNNPGGYECGCYAGYRLSADGCGCED 307
Score = 34.3 bits (75), Expect = 4.0
Identities = 12/26 (46%), Positives = 15/26 (57%)
Query: 1629 NPCKESNGGCSHLCLFRGHEYICACP 1654
N C+ +NGGCSH C +C CP
Sbjct: 228 NSCEANNGGCSHGCSHTSAGPLCTCP 253
Score = 33.9 bits (74), Expect = 5.3
Identities = 13/36 (36%), Positives = 16/36 (44%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C C+H CL G C C G +L DG+ C
Sbjct: 184 CAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQC 219
Score = 33.5 bits (73), Expect = 7.0
Identities = 11/33 (33%), Positives = 18/33 (54%)
Query: 1621 SADRQHGWNPCKESNGGCSHLCLFRGHEYICAC 1653
+ D++ + C+ NGGC H C+ Y+C C
Sbjct: 50 AGDQRPDVDECRTHNGGCQHRCVNTPGSYLCEC 82
Score = 33.5 bits (73), Expect = 7.0
Identities = 16/46 (34%), Positives = 23/46 (50%), Gaps = 1/46 (2%)
Query: 434 SAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQD 479
S+ CE C T G C+C G+ L ED+ C ++E M + D
Sbjct: 313 SSRGGCEHHC-TNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLD 357
>AB231860-1|BAE19678.1| 1640|Homo sapiens hypothetical protein
protein.
Length = 1640
Score = 75.4 bits (177), Expect = 2e-12
Identities = 37/102 (36%), Positives = 48/102 (47%), Gaps = 6/102 (5%)
Query: 418 CPRG----DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDE 473
CPRG D+ C C+ C+++C T G C C G+ L+ D C D+DE
Sbjct: 432 CPRGYELDTDQRTCIDVDDCADSPCCQQVC-TNNPGGYECGCYAGYRLSADGCGCEDVDE 490
Query: 474 CMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C + C C+N GSF+C C GY L D R C P E
Sbjct: 491 CASSRGG-CEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEE 531
Score = 66.9 bits (156), Expect = 6e-10
Identities = 63/231 (27%), Positives = 88/231 (38%), Gaps = 25/231 (10%)
Query: 288 CGDWT---DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIR 344
C W DE+ C + C+AG + G+C+P + + C G C+ + +
Sbjct: 186 CRGWMQQPDEEGC--LSAECSAG-LCFHGGRCVPGSAQPCH---CPPGFQGPRCQYD-VD 238
Query: 345 NCSLDEYTCADRRCVLK--TWLCDGVRDCTNGEDEMNCEV--SCEEDQYTCRPQEHLMSN 400
C C RCV ++LC+ D C SC C Q H +
Sbjct: 239 ECRTHNGGC-QHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGC--QHHCVQL 295
Query: 401 AFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEE-KCEKLCITTYDGHAACACPMGF 459
+H C +D C + C+ C C G A C C +G+
Sbjct: 296 TIT-----RHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRC-QVVRGLARCECHVGY 349
Query: 460 LLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSC 510
LA D +C D+DEC C+ C NT GSF+C C GY L D R C
Sbjct: 350 QLAADGKACEDVDECAAGLAQ-CAHGCLNTQGSFKCVCHAGYELGADGRQC 399
Score = 64.5 bits (150), Expect = 3e-09
Identities = 29/77 (37%), Positives = 37/77 (48%), Gaps = 3/77 (3%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCM 498
C C T G C CP G+ L D+ +C D+D+C P C Q C+N G + CGC
Sbjct: 417 CSHGCSHTSAG-PLCTCPRGYELDTDQRTCIDVDDC--ADSPCCQQVCTNNPGGYECGCY 473
Query: 499 TGYILRPDERSCKPTGE 515
GY L D C+ E
Sbjct: 474 AGYRLSADGCGCEDVDE 490
Score = 47.6 bits (108), Expect = 4e-04
Identities = 19/38 (50%), Positives = 22/38 (57%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NNGGCSH C G C CP G +L+ D +TC D
Sbjct: 410 CEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCID 447
Score = 47.2 bits (107), Expect = 5e-04
Identities = 34/135 (25%), Positives = 46/135 (34%), Gaps = 7/135 (5%)
Query: 384 CEEDQYTCRPQEHLMSNAFRNCVNR--KHVCDGMKDCPRGDDEERCPLKRKCS-AEEKCE 440
C+ D CR CVN ++C+ D C C+ C+
Sbjct: 233 CQYDVDECRTHN---GGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQ 289
Query: 441 KLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTG 500
C+ C C GF L ED C C ++ C C G RC C G
Sbjct: 290 HHCVQLTITRHRCQCRPGFQLQEDGRHCVRRSPCA-NRNGSCMHRCQVVRGLARCECHVG 348
Query: 501 YILRPDERSCKPTGE 515
Y L D ++C+ E
Sbjct: 349 YQLAADGKACEDVDE 363
Score = 45.2 bits (102), Expect = 0.002
Identities = 16/36 (44%), Positives = 21/36 (58%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C +NGGC H C+ PG C C G +L+ D +TC
Sbjct: 240 CRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTC 275
Score = 44.4 bits (100), Expect = 0.004
Identities = 34/123 (27%), Positives = 50/123 (40%), Gaps = 12/123 (9%)
Query: 399 SNAFRNCVNRKHVCDGMKDCP------RGDDEERCPLKRKCSAE-EKCEKLCITTYDGHA 451
+N +C++R V G+ C D + C +C+A +C C+ T G
Sbjct: 324 ANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQCAHGCLNT-QGSF 382
Query: 452 ACACPMGFLLAEDKYSCRDID----ECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDE 507
C C G+ L D C I+ + CS CS+T C C GY L D+
Sbjct: 383 KCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQ 442
Query: 508 RSC 510
R+C
Sbjct: 443 RTC 445
Score = 42.3 bits (95), Expect = 0.015
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NG C H C + G C C +G +L DGK C D
Sbjct: 323 CANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACED 360
Score = 41.5 bits (93), Expect = 0.027
Identities = 18/44 (40%), Positives = 24/44 (54%), Gaps = 2/44 (4%)
Query: 1315 ERVLENACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQT 1358
E + N+C +NGGCSH C + G C CP G +E T +T
Sbjct: 403 EMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRG--YELDTDQRT 444
Score = 38.3 bits (85), Expect = 0.25
Identities = 13/26 (50%), Positives = 15/26 (57%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTG 1347
C T NGGC H C+ +P Y C C G
Sbjct: 240 CRTHNGGCQHRCVNTPGSYLCECKPG 265
Score = 38.3 bits (85), Expect = 0.25
Identities = 13/37 (35%), Positives = 20/37 (54%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCA 1055
C + GGC H C G C+C G +L++D + C+
Sbjct: 491 CASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCS 527
Score = 35.5 bits (78), Expect = 1.7
Identities = 15/37 (40%), Positives = 19/37 (51%), Gaps = 1/37 (2%)
Query: 1019 CGKNNGGCSHLCL-LKPGGRSCACPIGIKLNKDGKTC 1054
C NGGC H C+ L C C G +L +DG+ C
Sbjct: 281 CALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHC 317
Score = 35.5 bits (78), Expect = 1.7
Identities = 13/31 (41%), Positives = 16/31 (51%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C +C PGG C C G +L+ DG C D
Sbjct: 457 CQQVCTNNPGGYECGCYAGYRLSADGCGCED 487
Score = 34.3 bits (75), Expect = 4.0
Identities = 12/26 (46%), Positives = 15/26 (57%)
Query: 1629 NPCKESNGGCSHLCLFRGHEYICACP 1654
N C+ +NGGCSH C +C CP
Sbjct: 408 NSCEANNGGCSHGCSHTSAGPLCTCP 433
Score = 33.9 bits (74), Expect = 5.3
Identities = 13/36 (36%), Positives = 16/36 (44%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C C+H CL G C C G +L DG+ C
Sbjct: 364 CAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQC 399
Score = 33.5 bits (73), Expect = 7.0
Identities = 11/29 (37%), Positives = 16/29 (55%)
Query: 1625 QHGWNPCKESNGGCSHLCLFRGHEYICAC 1653
Q+ + C+ NGGC H C+ Y+C C
Sbjct: 234 QYDVDECRTHNGGCQHRCVNTPGSYLCEC 262
Score = 33.5 bits (73), Expect = 7.0
Identities = 16/46 (34%), Positives = 23/46 (50%), Gaps = 1/46 (2%)
Query: 434 SAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQD 479
S+ CE C T G C+C G+ L ED+ C ++E M + D
Sbjct: 493 SSRGGCEHHC-TNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLD 537
>AB011539-1|BAA32467.2| 1246|Homo sapiens MEGF6 protein.
Length = 1246
Score = 75.4 bits (177), Expect = 2e-12
Identities = 37/102 (36%), Positives = 48/102 (47%), Gaps = 6/102 (5%)
Query: 418 CPRG----DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDE 473
CPRG D+ C C+ C+++C T G C C G+ L+ D C D+DE
Sbjct: 269 CPRGYELDTDQRTCIDVDDCADSPCCQQVC-TNNPGGYECGCYAGYRLSADGCGCEDVDE 327
Query: 474 CMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C + C C+N GSF+C C GY L D R C P E
Sbjct: 328 CASSRGG-CEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEE 368
Score = 65.3 bits (152), Expect = 2e-09
Identities = 74/295 (25%), Positives = 108/295 (36%), Gaps = 38/295 (12%)
Query: 239 CAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCV--PKDFQCDGDNDCGDWTDEDS 296
C L A P S +Q ++ C + C++ +CV P + C+ TD +
Sbjct: 53 CYPCHLGQAGYPVSAGDQRPDVDECRTHNGGCQH-RCVNTPGSYLCECKPGFRLHTDSRT 111
Query: 297 CPMVPGSCNAGEFKCNDGKCIP---ERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTC 353
C + SC G C C+ R RC D +C S C+ +C
Sbjct: 112 CLAI-NSCALGNGGCQH-HCVQLTITRHRCQCRPGFQLQEDGRHCVRRS--PCANRNGSC 167
Query: 354 ADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHL---MSNAFRNCVNR-- 408
R C VR E + +++ D C + ++ C+N
Sbjct: 168 MHR--------CQVVRGLARCECHVGYQLAA--DGKACEDVDECAAGLAQCAHGCLNTQG 217
Query: 409 --KHVCDGMKDCPRGDDEERC-----PLKRKCSAEEK-CEKLCITTYDGHAACACPMGFL 460
K VC + G D +C + C A C C T G C CP G+
Sbjct: 218 SFKCVCHAGYEL--GADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAG-PLCTCPRGYE 274
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
L D+ +C D+D+C P C Q C+N G + CGC GY L D C+ E
Sbjct: 275 LDTDQRTCIDVDDC--ADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDE 327
Score = 47.6 bits (108), Expect = 4e-04
Identities = 19/38 (50%), Positives = 22/38 (57%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NNGGCSH C G C CP G +L+ D +TC D
Sbjct: 247 CEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCID 284
Score = 45.2 bits (102), Expect = 0.002
Identities = 16/36 (44%), Positives = 21/36 (58%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C +NGGC H C+ PG C C G +L+ D +TC
Sbjct: 77 CRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTC 112
Score = 42.3 bits (95), Expect = 0.015
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NG C H C + G C C +G +L DGK C D
Sbjct: 160 CANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACED 197
Score = 41.5 bits (93), Expect = 0.027
Identities = 18/44 (40%), Positives = 24/44 (54%), Gaps = 2/44 (4%)
Query: 1315 ERVLENACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQT 1358
E + N+C +NGGCSH C + G C CP G +E T +T
Sbjct: 240 EMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRG--YELDTDQRT 281
Score = 38.3 bits (85), Expect = 0.25
Identities = 13/26 (50%), Positives = 15/26 (57%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTG 1347
C T NGGC H C+ +P Y C C G
Sbjct: 77 CRTHNGGCQHRCVNTPGSYLCECKPG 102
Score = 38.3 bits (85), Expect = 0.25
Identities = 13/37 (35%), Positives = 20/37 (54%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCA 1055
C + GGC H C G C+C G +L++D + C+
Sbjct: 328 CASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCS 364
Score = 35.5 bits (78), Expect = 1.7
Identities = 15/37 (40%), Positives = 19/37 (51%), Gaps = 1/37 (2%)
Query: 1019 CGKNNGGCSHLCL-LKPGGRSCACPIGIKLNKDGKTC 1054
C NGGC H C+ L C C G +L +DG+ C
Sbjct: 118 CALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHC 154
Score = 35.5 bits (78), Expect = 1.7
Identities = 13/31 (41%), Positives = 16/31 (51%)
Query: 1026 CSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C +C PGG C C G +L+ DG C D
Sbjct: 294 CQQVCTNNPGGYECGCYAGYRLSADGCGCED 324
Score = 34.3 bits (75), Expect = 4.0
Identities = 12/26 (46%), Positives = 15/26 (57%)
Query: 1629 NPCKESNGGCSHLCLFRGHEYICACP 1654
N C+ +NGGCSH C +C CP
Sbjct: 245 NSCEANNGGCSHGCSHTSAGPLCTCP 270
Score = 33.9 bits (74), Expect = 5.3
Identities = 13/36 (36%), Positives = 16/36 (44%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C C+H CL G C C G +L DG+ C
Sbjct: 201 CAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQC 236
Score = 33.5 bits (73), Expect = 7.0
Identities = 11/33 (33%), Positives = 18/33 (54%)
Query: 1621 SADRQHGWNPCKESNGGCSHLCLFRGHEYICAC 1653
+ D++ + C+ NGGC H C+ Y+C C
Sbjct: 67 AGDQRPDVDECRTHNGGCQHRCVNTPGSYLCEC 99
Score = 33.5 bits (73), Expect = 7.0
Identities = 16/46 (34%), Positives = 23/46 (50%), Gaps = 1/46 (2%)
Query: 434 SAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQD 479
S+ CE C T G C+C G+ L ED+ C ++E M + D
Sbjct: 330 SSRGGCEHHC-TNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLD 374
>AB208840-1|BAD92077.1| 830|Homo sapiens fibrillin 1 variant
protein.
Length = 830
Score = 74.9 bits (176), Expect = 2e-12
Identities = 73/265 (27%), Positives = 99/265 (37%), Gaps = 24/265 (9%)
Query: 259 ELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIP 318
+L+ C +ID EC+N ++ +C N G + C PG +CND
Sbjct: 237 KLLVCEDID-ECQNGPVCQRNAECI--NTAGSYR----CDCKPGYRFTSTGQCNDRNECQ 289
Query: 319 ERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDE 377
E + C D C ++ + D+ C D C C G C N
Sbjct: 290 EIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDINECERDA--C-GNGTCRNTIGS 346
Query: 378 MNCEVS---CEEDQYTCRPQEHLMS---NAFRN--CVNR--KHVCDGMKDCPRGDDEERC 427
NC + C + S N RN C+N C + D C
Sbjct: 347 FNCRCNHGFILSHNNDCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTC 406
Query: 428 PLKRKCSAE-EKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTC 486
+C E KC DG C CP G+ L +K C DIDEC+ E + TC
Sbjct: 407 VDINECLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNEK--CEDIDECVEEPEICALGTC 464
Query: 487 SNTVGSFRCGCMTGYILRPDERSCK 511
SNT GSF+C C G+ L R C+
Sbjct: 465 SNTEGSFKCLCPEGFSLSSSGRRCQ 489
Score = 65.7 bits (153), Expect = 1e-09
Identities = 32/83 (38%), Positives = 43/83 (51%), Gaps = 5/83 (6%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ---TCSNTVGSFRC 495
C C+ TY G C CP+G++L ED+ C+D DEC E C++ C N +G++ C
Sbjct: 652 CAFRCVNTY-GSYECKCPVGYVLREDRRMCKDEDEC-EEGKHDCTEKQMECKNLIGTYMC 709
Query: 496 GCMTGYILRPDERSCKPTGESPT 518
C GY RPD C E T
Sbjct: 710 ICGPGYQRRPDGEGCVDENECQT 732
Score = 64.5 bits (150), Expect = 3e-09
Identities = 66/231 (28%), Positives = 88/231 (38%), Gaps = 28/231 (12%)
Query: 293 DEDSCPMVPGSCN-------AGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRN 345
D D C +PG C G F+C +C + D C D DE P RN
Sbjct: 201 DIDECREIPGVCENGVCINMVGSFRC---ECPVGFFYNDKLLVCEDI-DECQNGPVCQRN 256
Query: 346 CSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNC 405
T RC K G R + G+ N C+E C + + + C
Sbjct: 257 AECIN-TAGSYRCDCKP----GYRFTSTGQ--CNDRNECQEIPNICSHGQCIDTVGSFYC 309
Query: 406 VNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDK 465
+ G K DD+ C +C + C T G C C GF+L+ +
Sbjct: 310 LCHT----GFKT---NDDQTMCLDINECERDACGNGTCRNTI-GSFNCRCNHGFILSHNN 361
Query: 466 YSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C D+DEC +C C NTVGSF+C C GY + PD R+C E
Sbjct: 362 -DCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINE 411
Score = 60.5 bits (140), Expect = 5e-08
Identities = 36/102 (35%), Positives = 45/102 (44%), Gaps = 6/102 (5%)
Query: 417 DCPRGD--DEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
+CP G C +CS C G C C GF +C DI+EC
Sbjct: 587 ECPFGYILAGNECVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPGP-MMTCEDINEC 645
Query: 475 MYEQDPV-CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
Q+P+ C+ C NT GS+ C C GY+LR D R CK E
Sbjct: 646 A--QNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDE 685
Score = 56.8 bits (131), Expect = 7e-07
Identities = 71/261 (27%), Positives = 107/261 (40%), Gaps = 33/261 (12%)
Query: 272 NTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDG-KCIPERWRCDNERDCA 330
N C+ D +C N G+ C GS +CN+G + P+ C + +C
Sbjct: 360 NNDCIDVD-ECASGN--GNLCRNGQCINTVGSFQC---QCNEGYEVAPDGRTCVDINECL 413
Query: 331 DGGDELNCKPNSIRNCSLDEYTC-ADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCE--ED 387
+ C P + +N Y C L+ C+ + +C E E+ +C E
Sbjct: 414 L--EPRKCAPGTCQNLD-GSYRCICPPGYSLQNEKCEDIDECVE-EPEICALGTCSNTEG 469
Query: 388 QYTCR-PQEHLMSNAFRNCVN-RKHVC-----DGMKDCPRGDDEER----CPLKRKCSAE 436
+ C P+ +S++ R C + R C G P+ + + C LK +
Sbjct: 470 SFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGE-GWG 528
Query: 437 EKCEKLCITTYDGHAACACPMGF-LLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFR 494
+ CE LC T D CP G ++ S D+DEC ++ VC C NT GS+R
Sbjct: 529 DPCE-LCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDEC--KEPDVCKHGQCINTDGSYR 585
Query: 495 CGCMTGYILRPDERSCKPTGE 515
C C GYIL +E C T E
Sbjct: 586 CECPFGYILAGNE--CVDTDE 604
Score = 55.2 bits (127), Expect = 2e-06
Identities = 32/94 (34%), Positives = 46/94 (48%), Gaps = 12/94 (12%)
Query: 418 CPRGDDEERCPLKRKCSAEEKCEKL--------CITTYDGHAACACPMGFLLAEDKYSCR 469
CP G+ P+ ++C++L CI T+ G C CP G+ L ED C
Sbjct: 24 CPGGEGFRPNPITVILEDIDECQELPGLCQGGKCINTF-GSFQCRCPTGYYLNEDTRVCD 82
Query: 470 DIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGYI 502
D++EC E +C TC NTVG++ C C Y+
Sbjct: 83 DVNEC--ETPGICGPGTCYNTVGNYTCICPPDYM 114
Score = 46.8 bits (106), Expect = 7e-04
Identities = 24/50 (48%), Positives = 26/50 (52%), Gaps = 2/50 (4%)
Query: 470 DIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGYILRPDERSCKPTGESPT 518
DIDEC E +C C NT GSF+C C TGY L D R C E T
Sbjct: 41 DIDECQ-ELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNECET 89
Score = 46.0 bits (104), Expect = 0.001
Identities = 28/90 (31%), Positives = 42/90 (46%), Gaps = 7/90 (7%)
Query: 423 DEERCPL-KRKCSAEE-KCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP 480
DE+ C K C+ ++ +C+ L I TY C C G+ D C D +EC +
Sbjct: 682 DEDECEEGKHDCTEKQMECKNL-IGTY----MCICGPGYQRRPDGEGCVDENECQTKPGI 736
Query: 481 VCSQTCSNTVGSFRCGCMTGYILRPDERSC 510
+ C NT GS+ C C G+ P++ C
Sbjct: 737 CENGRCLNTRGSYTCECNDGFTASPNQDEC 766
Score = 41.5 bits (93), Expect = 0.027
Identities = 53/222 (23%), Positives = 86/222 (38%), Gaps = 21/222 (9%)
Query: 258 VELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKC- 316
V++ C E D CK+ +C+ D + G + C + C+ G C +G C
Sbjct: 561 VDMDECKEPDV-CKHGQCINTDGSYRCECPFGYILAGNEC-VDTDECSVGN-PCGNGTCK 617
Query: 317 -IPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCV--LKTWLCDGVRDCTN 373
+ + C E + G + C+ I C+ + CA R CV ++ C
Sbjct: 618 NVIGGFECTCEEGF-EPGPMMTCE--DINECAQNPLLCAFR-CVNTYGSYECKCPVGYVL 673
Query: 374 GEDEMNC--EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKR 431
ED C E CEE ++ C ++ N ++C R D E C +
Sbjct: 674 REDRRMCKDEDECEEGKHDCTEKQMECKNLIGT-----YMCICGPGYQRRPDGEGCVDEN 728
Query: 432 KCSAEEK-CEK-LCITTYDGHAACACPMGFLLAEDKYSCRDI 471
+C + CE C+ T G C C GF + ++ C D+
Sbjct: 729 ECQTKPGICENGRCLNTR-GSYTCECNDGFTASPNQDECLDV 769
Score = 33.9 bits (74), Expect = 5.3
Identities = 13/38 (34%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C +N C+ C+ G C CP+G L +D + C D
Sbjct: 645 CAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKD 682
>Y13341-1|CAA73785.1| 310|Homo sapiens matrilin-3 precursor
protein.
Length = 310
Score = 74.5 bits (175), Expect = 3e-12
Identities = 52/183 (28%), Positives = 79/183 (43%), Gaps = 14/183 (7%)
Query: 350 EYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVS----CEEDQYTCRPQEHLMSNAF--- 402
E CA CVL T C V ++GE + +CE S D+ TC + N
Sbjct: 84 ETFCALDPCVLGTHQCQHVC-ISDGEGKHHCECSQGYTLNADKKTCSALDRCALNTHGCE 142
Query: 403 RNCVNRK---HVCDGMKDCPRGDDEERCPLKRKCS-AEEKCEKLCITTYDGHAACACPMG 458
CVN + + C+ + +D + C + KC+ C+ +C+ G C C G
Sbjct: 143 HICVNDRSGSYHCECYEGYTLNEDRKTCSAQDKCALGTHGCQHICVNDRTGSHHCECYEG 202
Query: 459 FLLAEDKYSCRDIDECMYEQDPVCSQTC-SNTVGSFRCGCMTGYILRPDERSCKPTGESP 517
+ L DK +C D+C C C S+ S+ C C GY L D+++C T E+
Sbjct: 203 YTLNADKKTCSVRDKCALGSHG-CQHICVSDGAASYHCDCYPGYTLNEDKKTCSATEEAR 261
Query: 518 TLL 520
L+
Sbjct: 262 RLV 264
Score = 38.7 bits (86), Expect = 0.19
Identities = 16/38 (42%), Positives = 21/38 (55%), Gaps = 1/38 (2%)
Query: 1019 CGKNNGGCSHLCLL-KPGGRSCACPIGIKLNKDGKTCA 1055
C N GC H+C+ + G C C G LN+D KTC+
Sbjct: 134 CALNTHGCEHICVNDRSGSYHCECYEGYTLNEDRKTCS 171
Score = 36.3 bits (80), Expect = 1.00
Identities = 15/38 (39%), Positives = 19/38 (50%), Gaps = 1/38 (2%)
Query: 1019 CGKNNGGCSHLCLL-KPGGRSCACPIGIKLNKDGKTCA 1055
C GC H+C+ + G C C G LN D KTC+
Sbjct: 176 CALGTHGCQHICVNDRTGSHHCECYEGYTLNADKKTCS 213
Score = 33.9 bits (74), Expect = 5.3
Identities = 16/39 (41%), Positives = 21/39 (53%), Gaps = 3/39 (7%)
Query: 1019 CGKNNGGCSHLCLLKPGGRS--CACPIGIKLNKDGKTCA 1055
C + GC H+C+ G S C C G LN+D KTC+
Sbjct: 218 CALGSHGCQHICV-SDGAASYHCDCYPGYTLNEDKKTCS 255
>BC139907-1|AAI39908.1| 486|Homo sapiens matrilin 3 protein.
Length = 486
Score = 74.5 bits (175), Expect = 3e-12
Identities = 52/183 (28%), Positives = 79/183 (43%), Gaps = 14/183 (7%)
Query: 350 EYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVS----CEEDQYTCRPQEHLMSNAF--- 402
E CA CVL T C V ++GE + +CE S D+ TC + N
Sbjct: 260 ETFCALDPCVLGTHQCQHVC-ISDGEGKHHCECSQGYTLNADKKTCSALDRCALNTHGCE 318
Query: 403 RNCVNRK---HVCDGMKDCPRGDDEERCPLKRKCS-AEEKCEKLCITTYDGHAACACPMG 458
CVN + + C+ + +D + C + KC+ C+ +C+ G C C G
Sbjct: 319 HICVNDRSGSYHCECYEGYTLNEDRKTCSAQDKCALGTHGCQHICVNDRTGSHHCECYEG 378
Query: 459 FLLAEDKYSCRDIDECMYEQDPVCSQTC-SNTVGSFRCGCMTGYILRPDERSCKPTGESP 517
+ L DK +C D+C C C S+ S+ C C GY L D+++C T E+
Sbjct: 379 YTLNADKKTCSVRDKCALGSHG-CQHICVSDGAASYHCDCYPGYTLNEDKKTCSATEEAR 437
Query: 518 TLL 520
L+
Sbjct: 438 RLV 440
Score = 38.7 bits (86), Expect = 0.19
Identities = 16/38 (42%), Positives = 21/38 (55%), Gaps = 1/38 (2%)
Query: 1019 CGKNNGGCSHLCLL-KPGGRSCACPIGIKLNKDGKTCA 1055
C N GC H+C+ + G C C G LN+D KTC+
Sbjct: 310 CALNTHGCEHICVNDRSGSYHCECYEGYTLNEDRKTCS 347
Score = 36.3 bits (80), Expect = 1.00
Identities = 15/38 (39%), Positives = 19/38 (50%), Gaps = 1/38 (2%)
Query: 1019 CGKNNGGCSHLCLL-KPGGRSCACPIGIKLNKDGKTCA 1055
C GC H+C+ + G C C G LN D KTC+
Sbjct: 352 CALGTHGCQHICVNDRTGSHHCECYEGYTLNADKKTCS 389
Score = 33.9 bits (74), Expect = 5.3
Identities = 16/39 (41%), Positives = 21/39 (53%), Gaps = 3/39 (7%)
Query: 1019 CGKNNGGCSHLCLLKPGGRS--CACPIGIKLNKDGKTCA 1055
C + GC H+C+ G S C C G LN+D KTC+
Sbjct: 394 CALGSHGCQHICV-SDGAASYHCDCYPGYTLNEDKKTCS 431
>AJ224741-1|CAA12110.1| 486|Homo sapiens matrilin-3 protein.
Length = 486
Score = 74.5 bits (175), Expect = 3e-12
Identities = 52/183 (28%), Positives = 79/183 (43%), Gaps = 14/183 (7%)
Query: 350 EYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVS----CEEDQYTCRPQEHLMSNAF--- 402
E CA CVL T C V ++GE + +CE S D+ TC + N
Sbjct: 260 ETFCALDPCVLGTHQCQHVC-ISDGEGKHHCECSQGYTLNADKKTCSALDRCALNTHGCE 318
Query: 403 RNCVNRK---HVCDGMKDCPRGDDEERCPLKRKCS-AEEKCEKLCITTYDGHAACACPMG 458
CVN + + C+ + +D + C + KC+ C+ +C+ G C C G
Sbjct: 319 HICVNDRSGSYHCECYEGYTLNEDRKTCSAQDKCALGTHGCQHICVNDRTGSHHCECYEG 378
Query: 459 FLLAEDKYSCRDIDECMYEQDPVCSQTC-SNTVGSFRCGCMTGYILRPDERSCKPTGESP 517
+ L DK +C D+C C C S+ S+ C C GY L D+++C T E+
Sbjct: 379 YTLNADKKTCSVRDKCALGSHG-CQHICVSDGAASYHCDCYPGYTLNEDKKTCSATEEAR 437
Query: 518 TLL 520
L+
Sbjct: 438 RLV 440
Score = 38.7 bits (86), Expect = 0.19
Identities = 16/38 (42%), Positives = 21/38 (55%), Gaps = 1/38 (2%)
Query: 1019 CGKNNGGCSHLCLL-KPGGRSCACPIGIKLNKDGKTCA 1055
C N GC H+C+ + G C C G LN+D KTC+
Sbjct: 310 CALNTHGCEHICVNDRSGSYHCECYEGYTLNEDRKTCS 347
Score = 36.3 bits (80), Expect = 1.00
Identities = 15/38 (39%), Positives = 19/38 (50%), Gaps = 1/38 (2%)
Query: 1019 CGKNNGGCSHLCLL-KPGGRSCACPIGIKLNKDGKTCA 1055
C GC H+C+ + G C C G LN D KTC+
Sbjct: 352 CALGTHGCQHICVNDRTGSHHCECYEGYTLNADKKTCS 389
Score = 33.9 bits (74), Expect = 5.3
Identities = 16/39 (41%), Positives = 21/39 (53%), Gaps = 3/39 (7%)
Query: 1019 CGKNNGGCSHLCLLKPGGRS--CACPIGIKLNKDGKTCA 1055
C + GC H+C+ G S C C G LN+D KTC+
Sbjct: 394 CALGSHGCQHICV-SDGAASYHCDCYPGYTLNEDKKTCS 431
>AJ001047-1|CAA04501.1| 303|Homo sapiens Matrilin-3 protein.
Length = 303
Score = 74.5 bits (175), Expect = 3e-12
Identities = 52/183 (28%), Positives = 79/183 (43%), Gaps = 14/183 (7%)
Query: 350 EYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVS----CEEDQYTCRPQEHLMSNAF--- 402
E CA CVL T C V ++GE + +CE S D+ TC + N
Sbjct: 77 ETFCALDPCVLGTHQCQHVC-ISDGEGKHHCECSQGYTLNADKKTCSALDRCALNTHGCE 135
Query: 403 RNCVNRK---HVCDGMKDCPRGDDEERCPLKRKCS-AEEKCEKLCITTYDGHAACACPMG 458
CVN + + C+ + +D + C + KC+ C+ +C+ G C C G
Sbjct: 136 HICVNDRSGSYHCECYEGYTLNEDRKTCSAQDKCALGTHGCQHICVNDRTGSHHCECYEG 195
Query: 459 FLLAEDKYSCRDIDECMYEQDPVCSQTC-SNTVGSFRCGCMTGYILRPDERSCKPTGESP 517
+ L DK +C D+C C C S+ S+ C C GY L D+++C T E+
Sbjct: 196 YTLNADKKTCSVRDKCALGSHG-CQHICVSDGAASYHCDCYPGYTLNEDKKTCSATEEAR 254
Query: 518 TLL 520
L+
Sbjct: 255 RLV 257
Score = 38.7 bits (86), Expect = 0.19
Identities = 16/38 (42%), Positives = 21/38 (55%), Gaps = 1/38 (2%)
Query: 1019 CGKNNGGCSHLCLL-KPGGRSCACPIGIKLNKDGKTCA 1055
C N GC H+C+ + G C C G LN+D KTC+
Sbjct: 127 CALNTHGCEHICVNDRSGSYHCECYEGYTLNEDRKTCS 164
Score = 36.3 bits (80), Expect = 1.00
Identities = 15/38 (39%), Positives = 19/38 (50%), Gaps = 1/38 (2%)
Query: 1019 CGKNNGGCSHLCLL-KPGGRSCACPIGIKLNKDGKTCA 1055
C GC H+C+ + G C C G LN D KTC+
Sbjct: 169 CALGTHGCQHICVNDRTGSHHCECYEGYTLNADKKTCS 206
Score = 33.9 bits (74), Expect = 5.3
Identities = 16/39 (41%), Positives = 21/39 (53%), Gaps = 3/39 (7%)
Query: 1019 CGKNNGGCSHLCLLKPGGRS--CACPIGIKLNKDGKTCA 1055
C + GC H+C+ G S C C G LN+D KTC+
Sbjct: 211 CALGSHGCQHICV-SDGAASYHCDCYPGYTLNEDKKTCS 248
>AC079145-2|AAX88937.1| 486|Homo sapiens unknown protein.
Length = 486
Score = 74.5 bits (175), Expect = 3e-12
Identities = 52/183 (28%), Positives = 79/183 (43%), Gaps = 14/183 (7%)
Query: 350 EYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVS----CEEDQYTCRPQEHLMSNAF--- 402
E CA CVL T C V ++GE + +CE S D+ TC + N
Sbjct: 260 ETFCALDPCVLGTHQCQHVC-ISDGEGKHHCECSQGYTLNADKKTCSALDRCALNTHGCE 318
Query: 403 RNCVNRK---HVCDGMKDCPRGDDEERCPLKRKCS-AEEKCEKLCITTYDGHAACACPMG 458
CVN + + C+ + +D + C + KC+ C+ +C+ G C C G
Sbjct: 319 HICVNDRSGSYHCECYEGYTLNEDRKTCSAQDKCALGTHGCQHICVNDRTGSHHCECYEG 378
Query: 459 FLLAEDKYSCRDIDECMYEQDPVCSQTC-SNTVGSFRCGCMTGYILRPDERSCKPTGESP 517
+ L DK +C D+C C C S+ S+ C C GY L D+++C T E+
Sbjct: 379 YTLNADKKTCSVRDKCALGSHG-CQHICVSDGAASYHCDCYPGYTLNEDKKTCSATEEAR 437
Query: 518 TLL 520
L+
Sbjct: 438 RLV 440
Score = 38.7 bits (86), Expect = 0.19
Identities = 16/38 (42%), Positives = 21/38 (55%), Gaps = 1/38 (2%)
Query: 1019 CGKNNGGCSHLCLL-KPGGRSCACPIGIKLNKDGKTCA 1055
C N GC H+C+ + G C C G LN+D KTC+
Sbjct: 310 CALNTHGCEHICVNDRSGSYHCECYEGYTLNEDRKTCS 347
Score = 36.3 bits (80), Expect = 1.00
Identities = 15/38 (39%), Positives = 19/38 (50%), Gaps = 1/38 (2%)
Query: 1019 CGKNNGGCSHLCLL-KPGGRSCACPIGIKLNKDGKTCA 1055
C GC H+C+ + G C C G LN D KTC+
Sbjct: 352 CALGTHGCQHICVNDRTGSHHCECYEGYTLNADKKTCS 389
Score = 33.9 bits (74), Expect = 5.3
Identities = 16/39 (41%), Positives = 21/39 (53%), Gaps = 3/39 (7%)
Query: 1019 CGKNNGGCSHLCLLKPGGRS--CACPIGIKLNKDGKTCA 1055
C + GC H+C+ G S C C G LN+D KTC+
Sbjct: 394 CALGSHGCQHICV-SDGAASYHCDCYPGYTLNEDKKTCS 431
>AK092062-1|BAC03798.1| 880|Homo sapiens protein ( Homo sapiens
cDNA FLJ34743 fis, clone MESAN2009019, moderately
similar to CEGP1 protein. ).
Length = 880
Score = 74.1 bits (174), Expect = 4e-12
Identities = 33/77 (42%), Positives = 42/77 (54%), Gaps = 2/77 (2%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCM 498
C+ C G C CP+GF+L D+ +C+DIDEC C C NTVGSF C C
Sbjct: 134 CDSKCHDAATG-VHCTCPVGFMLQPDRKTCKDIDECRLNNGG-CDHICRNTVGSFECSCK 191
Query: 499 TGYILRPDERSCKPTGE 515
GY L +ER+C+ E
Sbjct: 192 KGYKLLINERNCQDIDE 208
Score = 61.7 bits (143), Expect = 2e-08
Identities = 33/91 (36%), Positives = 46/91 (50%), Gaps = 8/91 (8%)
Query: 418 CPRG----DDEERCPLKRKCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDID 472
CP G D + C +C C+ +C T G C+C G+ L ++ +C+DID
Sbjct: 149 CPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTV-GSFECSCKKGYKLLINERNCQDID 207
Query: 473 ECMYEQDPVCSQTCSNTVGSFRCGCMTGYIL 503
EC + D C C NT GSF+C C GY+L
Sbjct: 208 ECSF--DRTCDHICVNTPGSFQCLCHRGYLL 236
Score = 57.6 bits (133), Expect = 4e-07
Identities = 65/277 (23%), Positives = 104/277 (37%), Gaps = 19/277 (6%)
Query: 235 YESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNT-KCVPKD-FQCDGDNDCGDWT 292
YE C ++ + N + +P E M C + C + + PK C+
Sbjct: 5 YECHC-REGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTK 63
Query: 293 DEDSCPMVPGSCNAG-EFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEY 351
++ C + N G + C+D + P RC D C +
Sbjct: 64 NQRDCKLTCNYGNGGCQHTCDDTEQGP---RCGCHIKFVLHTDGKTCIGERRLEQHIPTQ 120
Query: 352 TCADRRCVLKTWLCDG-VRDCTNGEDEMNCEVS--CEEDQYTCRP-QEHLMSNAFRNCVN 407
++ C + CD D G C V + D+ TC+ E ++N + +
Sbjct: 121 AVSNETCAVNNGGCDSKCHDAATGV-HCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHIC 179
Query: 408 RKHVCDGMKDCPRGD----DEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAE 463
R V C +G +E C +CS + C+ +C+ T G C C G+LL
Sbjct: 180 RNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTCDHICVNT-PGSFQCLCHRGYLLYG 238
Query: 464 DKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTG 500
+ C D+DEC + C C NT GS++C C G
Sbjct: 239 ITH-CGDVDECSINRGG-CRFGCINTPGSYQCTCPAG 273
Score = 48.4 bits (110), Expect = 2e-04
Identities = 24/72 (33%), Positives = 34/72 (47%), Gaps = 3/72 (4%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCM 498
C +C T G AC C GF L +++ C+ C Y C TC +T RCGC
Sbjct: 39 CAHICRETPKGGIACECRPGFELTKNQRDCKLT--CNYGNGG-CQHTCDDTEQGPRCGCH 95
Query: 499 TGYILRPDERSC 510
++L D ++C
Sbjct: 96 IKFVLHTDGKTC 107
Score = 44.8 bits (101), Expect = 0.003
Identities = 18/38 (47%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NNGGC C G C CP+G L D KTC D
Sbjct: 127 CAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKD 164
Score = 41.9 bits (94), Expect = 0.020
Identities = 18/38 (47%), Positives = 19/38 (50%)
Query: 1017 LGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
L C NGGC H C G C C I L+ DGKTC
Sbjct: 70 LTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTC 107
Score = 40.3 bits (90), Expect = 0.061
Identities = 16/38 (42%), Positives = 20/38 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NNGGC H+C G C+C G KL + + C D
Sbjct: 168 CRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQD 205
Score = 39.5 bits (88), Expect = 0.11
Identities = 22/70 (31%), Positives = 34/70 (48%), Gaps = 6/70 (8%)
Query: 449 GHAACACPMGFLLAEDKYSCRDIDE----CMYEQDPVCSQTCSNTV-GSFRCGCMTGYIL 503
G C C GF L++++++C E CM ++ C+ C T G C C G+ L
Sbjct: 3 GSYECHCREGFFLSDNQHTCIQRPEEGMNCM-NKNHGCAHICRETPKGGIACECRPGFEL 61
Query: 504 RPDERSCKPT 513
++R CK T
Sbjct: 62 TKNQRDCKLT 71
Score = 39.1 bits (87), Expect = 0.14
Identities = 16/39 (41%), Positives = 21/39 (53%), Gaps = 1/39 (2%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGI-KLNKDGKTCAD 1056
C N GGC C+ PG C CP G +L+ +GK C +
Sbjct: 248 CSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTE 286
Score = 37.9 bits (84), Expect = 0.33
Identities = 15/39 (38%), Positives = 22/39 (56%), Gaps = 1/39 (2%)
Query: 1017 LGCGKNNGGCSHLCLLKP-GGRSCACPIGIKLNKDGKTC 1054
+ C N GC+H+C P GG +C C G +L K+ + C
Sbjct: 30 MNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDC 68
Score = 36.7 bits (81), Expect = 0.76
Identities = 17/47 (36%), Positives = 22/47 (46%), Gaps = 2/47 (4%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTGM-PFEKSTTDQT-PKKCKSHP 1366
C + GGC C+ +P Y C CP G + D T P KC+ P
Sbjct: 248 CSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSP 294
Score = 35.5 bits (78), Expect = 1.7
Identities = 13/36 (36%), Positives = 17/36 (47%)
Query: 1312 IQSERVLENACGTDNGGCSHLCLRSPLGYTCACPTG 1347
I ++ V C +NGGC C + G C CP G
Sbjct: 117 IPTQAVSNETCAVNNGGCDSKCHDAATGVHCTCPVG 152
>X62009-1|CAB56757.1| 754|Homo sapiens fibrillin 5 protein.
Length = 754
Score = 73.7 bits (173), Expect = 5e-12
Identities = 83/303 (27%), Positives = 124/303 (40%), Gaps = 50/303 (16%)
Query: 258 VELMRCAEIDFECKNTKCVPK--DFQCD------GDNDCGDWTDEDSCPMVPGSCNA--- 306
V++ C+ D C+N KCV +QC D TD D C ++ G C+
Sbjct: 447 VDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCT 506
Query: 307 ---GEFKCN---------DGKCIPERWRCDNERDCADGGD------ELNCKPNSIRNCSL 348
G ++C+ DG+ + C+N D DGG E C S+
Sbjct: 507 NSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASM 566
Query: 349 DEYTCAD-RRCVLKTWLCD-GVRDCTNGEDEMNCEV--SCEEDQYTCRPQEHLMSNAFRN 404
D TC D C L + +C G + T G +C++ S ++ C + A N
Sbjct: 567 DMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGA-HN 625
Query: 405 C---VNRKHVCDGMK-DCPRG--DDEERCPLKRKCS-AEEKCE--KLCITTYDGHAACAC 455
C + ++ K C G + +C + +CS +C C+ T G CAC
Sbjct: 626 CDMHASCLNIPGSFKCSCREGWIGNGIKCIDRDECSNGTHQCSINAQCVNT-PGSYRCAC 684
Query: 456 PMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGYILRPDERSCKPTG 514
GF D ++C D+DEC E +C C N G++RC C G+ D RSC+ G
Sbjct: 685 SEGF--TGDGFTCSDVDECA-ENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQ--G 739
Query: 515 ESP 517
SP
Sbjct: 740 GSP 742
Score = 66.9 bits (156), Expect = 6e-10
Identities = 64/255 (25%), Positives = 95/255 (37%), Gaps = 22/255 (8%)
Query: 269 ECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCI--PERWRCDNE 326
+C+NT F+C ++ +E +C + C C G C+ P + C+
Sbjct: 336 KCRNTI---GSFKCRCNSGFALDMEERNCTDID-ECRISPDLCGSGICVNTPGSFECECF 391
Query: 327 RDCADGGDEL-NCKPNSIRNCSLDEYTCADRRCVLK--TWLCDGVRDCTNGEDEMNCEVS 383
G + NC I C + C CV ++ CD C G +
Sbjct: 392 EGYESGFMMMKNCM--DIDGCERNPLLCRGGTCVNTEGSFQCD----CPLGHELSPSRED 445
Query: 384 CEEDQYTCRPQEHLMSNAFRNCVNR--KHVCDGMKDCPRGDDEERCPLKRKCSAEEK-CE 440
C D C ++L N CVN + C D + C +C C+
Sbjct: 446 CV-DINECSLSDNLCRNG--KCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCD 502
Query: 441 KLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTG 500
C T +G C+C G+ L D SC DIDEC D C+N G +RC C G
Sbjct: 503 TQC-TNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDG 561
Query: 501 YILRPDERSCKPTGE 515
++ D ++C E
Sbjct: 562 FMASMDMKTCIDVNE 576
Score = 63.7 bits (148), Expect = 6e-09
Identities = 61/258 (23%), Positives = 95/258 (36%), Gaps = 30/258 (11%)
Query: 270 CKNTKCVPKDFQCDG-DNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPER--WRCDNE 326
C NT P F+C+ + + +C + G C C G C+ ++CD
Sbjct: 379 CVNT---PGSFECECFEGYESGFMMMKNCMDIDG-CERNPLLCRGGTCVNTEGSFQCDCP 434
Query: 327 RDCADGGDELNCKPNSIRNCSLDEYTCADRRCV--LKTWLCDGVRDCTNGEDEMNCEVSC 384
+C I CSL + C + +CV + T+ C C G C
Sbjct: 435 LGHELSPSREDCV--DINECSLSDNLCRNGKCVNMIGTYQCS----CNPGYQATPDRQGC 488
Query: 385 EEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEK--- 441
+ E ++ N C + +G +C + P R C+ ++CE
Sbjct: 489 TDID------ECMIMNG--GCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPD 540
Query: 442 LC----ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGC 497
+C T G C C GF+ + D +C D++EC + C NT GSF C C
Sbjct: 541 ICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHC 600
Query: 498 MTGYILRPDERSCKPTGE 515
GY ++ C E
Sbjct: 601 QLGYSVKKGTTGCTDVDE 618
Score = 53.6 bits (123), Expect = 6e-06
Identities = 30/95 (31%), Positives = 40/95 (42%), Gaps = 5/95 (5%)
Query: 421 GDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP 480
G D C L A CE L G C C G+ +C DIDEC+ +
Sbjct: 14 GRDINECALDPDICANGICENL-----RGSYRCNCNSGYEPDASGRNCIDIDECLVNRLL 68
Query: 481 VCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
+ C NT GS+ C C GY+ R + +C+ E
Sbjct: 69 CDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINE 103
Score = 52.4 bits (120), Expect = 1e-05
Identities = 23/59 (38%), Positives = 32/59 (54%), Gaps = 3/59 (5%)
Query: 442 LCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTG 500
LC T G +C CP G++ + +C DI+EC E +P + C N +GSF C C G
Sbjct: 73 LCRNT-PGSYSCTCPPGYVFRTETETCEDINEC--ESNPCVNGACRNNLGSFNCECSPG 128
Score = 38.7 bits (86), Expect = 0.19
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NGGC C G C+C G L DG++CAD
Sbjct: 494 CMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCAD 531
Score = 38.3 bits (85), Expect = 0.25
Identities = 54/206 (26%), Positives = 72/206 (34%), Gaps = 33/206 (16%)
Query: 315 KCIPERWRCDNERDCAD--GGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCT 372
+C+ R CDN C + G C P + + TC D +G C
Sbjct: 61 ECLVNRLLCDNGL-CRNTPGSYSCTCPPGYVFRTETE--TCEDINECESNPCVNGA--CR 115
Query: 373 NGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCD-GMKDCPRGDDEERCPLKR 431
N NCE C P L S + K C ++D + LK
Sbjct: 116 NNLGSFNCE---------CSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKS 166
Query: 432 KCSAE------EKCEKLCITTYDGHAACACPMGFLLAEDK-YSCRDIDECMYEQDPVCSQ 484
+C A CE+ + T ACP G LA K +C D++EC +
Sbjct: 167 ECCATLGAAWGSPCERCELDT-------ACPRG--LARIKGVTCEDVNECEVFPGVCPNG 217
Query: 485 TCSNTVGSFRCGCMTGYILRPDERSC 510
C N+ GSF C C G L R C
Sbjct: 218 RCVNSKGSFHCECPEGLTLDGTGRVC 243
Score = 35.1 bits (77), Expect = 2.3
Identities = 20/56 (35%), Positives = 27/56 (48%), Gaps = 5/56 (8%)
Query: 1312 IQSERVLENACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKST-TDQTPKKCKSHP 1366
I + L N DNG LC +P Y+C CP G F T T + +C+S+P
Sbjct: 57 IDIDECLVNRLLCDNG----LCRNTPGSYSCTCPPGYVFRTETETCEDINECESNP 108
>U03877-1|AAA65590.1| 387|Homo sapiens extracellular protein
protein.
Length = 387
Score = 73.7 bits (173), Expect = 5e-12
Identities = 48/161 (29%), Positives = 72/161 (44%), Gaps = 13/161 (8%)
Query: 366 DGVRDCTNGEDEMNCEVSCEEDQYT-CRPQEHLMSNAFRNCVNRKHVCDGMK-----DCP 419
D R +N + C E+ ++ C+ + + NC VC ++ CP
Sbjct: 39 DPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGT-HNC-RADQVCINLRGSFACQCP 96
Query: 420 RGDDE--ERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYE 477
G + E+C +C+ C + C+ T G C C GF LA + Y+C DI+EC +
Sbjct: 97 PGYQKRGEQCVDIDECTIPPYCHQRCVNT-PGSFYCQCSPGFQLAANNYTCVDINEC--D 153
Query: 478 QDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPT 518
C+Q C N +GSF C C GY L D +C+ E T
Sbjct: 154 ASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT 194
Score = 49.2 bits (112), Expect = 1e-04
Identities = 41/159 (25%), Positives = 62/159 (38%), Gaps = 15/159 (9%)
Query: 371 CTNGEDEMNCEVS----CEEDQYTCRP-QEHLMSN-AFRNCVN--RKHVCDGMKDCPRGD 422
C N C+ S + YTC E SN + C N +C +
Sbjct: 122 CVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSS 181
Query: 423 DEERCPLKRKC-SAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV 481
D C +C ++ C+ C+ G +C CP G+ + + +C+DI+EC +
Sbjct: 182 DRLNCEDIDECRTSSYLCQYQCVNE-PGKFSCMCPQGYQVVRSR-TCQDINECETTNECR 239
Query: 482 CSQTCSNTVGSFRC----GCMTGYILRPDERSCKPTGES 516
+ C N G FRC C YIL P+ R P +
Sbjct: 240 EDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNA 278
Score = 34.3 bits (75), Expect = 4.0
Identities = 14/46 (30%), Positives = 23/46 (50%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPE 1367
C T + C + C+ P ++C CP G +S T Q +C++ E
Sbjct: 192 CRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNE 237
>CR456446-1|CAG30332.1| 824|Homo sapiens dJ1170K4.2 protein.
Length = 824
Score = 73.7 bits (173), Expect = 5e-12
Identities = 45/125 (36%), Positives = 58/125 (46%), Gaps = 22/125 (17%)
Query: 307 GEFKCN-DGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLC 365
GEF C+ +G C+P CD +DC +G DE NC + C D C+ +C
Sbjct: 451 GEFLCSVNGLCVPA---CDGVKDCPNGLDERNCVCRATFQCK------EDSTCISLPKVC 501
Query: 366 DGVRDCTNGEDEMNCE--VSCEEDQYTCRPQEHLMSNAFRNCVNRKH-VCDGMKDCPRGD 422
DG DC NG DE C+ V C + C R+CV + + CDG DC G
Sbjct: 502 DGQPDCLNGSDEEQCQEGVPCGTFTFQCED---------RSCVKKPNPQCDGRPDCRDGS 552
Query: 423 DEERC 427
DEE C
Sbjct: 553 DEEHC 557
Score = 70.5 bits (165), Expect = 5e-11
Identities = 45/118 (38%), Positives = 56/118 (47%), Gaps = 14/118 (11%)
Query: 267 DFECK-NTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCN-DGKCIPERWRCD 324
+F C N CVP CDG DC + DE +C C A F+C D CI CD
Sbjct: 452 EFLCSVNGLCVPA---CDGVKDCPNGLDERNCV-----CRA-TFQCKEDSTCISLPKVCD 502
Query: 325 NERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLK-TWLCDGVRDCTNGEDEMNCE 381
+ DC +G DE C+ C + C DR CV K CDG DC +G DE +C+
Sbjct: 503 GQPDCLNGSDEEQCQEGV--PCGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCD 558
Score = 39.9 bits (89), Expect = 0.081
Identities = 16/36 (44%), Positives = 22/36 (61%), Gaps = 1/36 (2%)
Query: 263 CAEIDFECKNTKCVPK-DFQCDGDNDCGDWTDEDSC 297
C F+C++ CV K + QCDG DC D +DE+ C
Sbjct: 522 CGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHC 557
Score = 38.7 bits (86), Expect = 0.19
Identities = 27/96 (28%), Positives = 37/96 (38%), Gaps = 11/96 (11%)
Query: 412 CDGMKDCPRGDDEERCPLKR--KCSAEEKC---EKLCITTYD---GHAACACPMGFLLAE 463
CDG+KDCP G DE C + +C + C K+C D G C G
Sbjct: 465 CDGVKDCPNGLDERNCVCRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGT 524
Query: 464 DKYSCRDIDECMYEQDPVCS--QTCSNTVGSFRCGC 497
+ C D C+ + +P C C + C C
Sbjct: 525 FTFQCED-RSCVKKPNPQCDGRPDCRDGSDEEHCDC 559
Score = 33.1 bits (72), Expect = 9.3
Identities = 13/29 (44%), Positives = 17/29 (58%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINC 195
C + CI+L +CDG DC + SDE C
Sbjct: 488 CKEDSTCISLPKVCDGQPDCLNGSDEEQC 516
>BC098561-1|AAH98561.1| 493|Homo sapiens EGF-containing
fibulin-like extracellular matrix protein 1 protein.
Length = 493
Score = 73.7 bits (173), Expect = 5e-12
Identities = 48/161 (29%), Positives = 72/161 (44%), Gaps = 13/161 (8%)
Query: 366 DGVRDCTNGEDEMNCEVSCEEDQYT-CRPQEHLMSNAFRNCVNRKHVCDGMK-----DCP 419
D R +N + C E+ ++ C+ + + NC VC ++ CP
Sbjct: 145 DPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGT-HNC-RADQVCINLRGSFACQCP 202
Query: 420 RGDDE--ERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYE 477
G + E+C +C+ C + C+ T G C C GF LA + Y+C DI+EC +
Sbjct: 203 PGYQKRGEQCVDIDECTIPPYCHQRCVNT-PGSFYCQCSPGFQLAANNYTCVDINEC--D 259
Query: 478 QDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPT 518
C+Q C N +GSF C C GY L D +C+ E T
Sbjct: 260 ASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT 300
Score = 49.2 bits (112), Expect = 1e-04
Identities = 41/159 (25%), Positives = 62/159 (38%), Gaps = 15/159 (9%)
Query: 371 CTNGEDEMNCEVS----CEEDQYTCRP-QEHLMSN-AFRNCVN--RKHVCDGMKDCPRGD 422
C N C+ S + YTC E SN + C N +C +
Sbjct: 228 CVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSS 287
Query: 423 DEERCPLKRKC-SAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV 481
D C +C ++ C+ C+ G +C CP G+ + + +C+DI+EC +
Sbjct: 288 DRLNCEDIDECRTSSYLCQYQCVNE-PGKFSCMCPQGYQVVRSR-TCQDINECETTNECR 345
Query: 482 CSQTCSNTVGSFRC----GCMTGYILRPDERSCKPTGES 516
+ C N G FRC C YIL P+ R P +
Sbjct: 346 EDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNA 384
Score = 34.3 bits (75), Expect = 4.0
Identities = 14/46 (30%), Positives = 23/46 (50%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPE 1367
C T + C + C+ P ++C CP G +S T Q +C++ E
Sbjct: 298 CRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNE 343
>BC014410-1|AAH14410.1| 493|Homo sapiens EGF-containing
fibulin-like extracellular matrix protein 1 protein.
Length = 493
Score = 73.7 bits (173), Expect = 5e-12
Identities = 48/161 (29%), Positives = 72/161 (44%), Gaps = 13/161 (8%)
Query: 366 DGVRDCTNGEDEMNCEVSCEEDQYT-CRPQEHLMSNAFRNCVNRKHVCDGMK-----DCP 419
D R +N + C E+ ++ C+ + + NC VC ++ CP
Sbjct: 145 DPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGT-HNC-RADQVCINLRGSFACQCP 202
Query: 420 RGDDE--ERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYE 477
G + E+C +C+ C + C+ T G C C GF LA + Y+C DI+EC +
Sbjct: 203 PGYQKRGEQCVDIDECTIPPYCHQRCVNT-PGSFYCQCSPGFQLAANNYTCVDINEC--D 259
Query: 478 QDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPT 518
C+Q C N +GSF C C GY L D +C+ E T
Sbjct: 260 ASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT 300
Score = 49.2 bits (112), Expect = 1e-04
Identities = 41/159 (25%), Positives = 62/159 (38%), Gaps = 15/159 (9%)
Query: 371 CTNGEDEMNCEVS----CEEDQYTCRP-QEHLMSN-AFRNCVN--RKHVCDGMKDCPRGD 422
C N C+ S + YTC E SN + C N +C +
Sbjct: 228 CVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSS 287
Query: 423 DEERCPLKRKC-SAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV 481
D C +C ++ C+ C+ G +C CP G+ + + +C+DI+EC +
Sbjct: 288 DRLNCEDIDECRTSSYLCQYQCVNE-PGKFSCMCPQGYQVVRSR-TCQDINECETTNECR 345
Query: 482 CSQTCSNTVGSFRC----GCMTGYILRPDERSCKPTGES 516
+ C N G FRC C YIL P+ R P +
Sbjct: 346 EDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNA 384
Score = 34.3 bits (75), Expect = 4.0
Identities = 14/46 (30%), Positives = 23/46 (50%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPE 1367
C T + C + C+ P ++C CP G +S T Q +C++ E
Sbjct: 298 CRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNE 343
>AY358398-1|AAQ88764.1| 802|Homo sapiens PVAE354 protein.
Length = 802
Score = 73.7 bits (173), Expect = 5e-12
Identities = 45/125 (36%), Positives = 58/125 (46%), Gaps = 22/125 (17%)
Query: 307 GEFKCN-DGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLC 365
GEF C+ +G C+P CD +DC +G DE NC + C D C+ +C
Sbjct: 451 GEFLCSVNGLCVPA---CDGVKDCPNGLDERNCVCRATFQCK------EDSTCISLPKVC 501
Query: 366 DGVRDCTNGEDEMNCE--VSCEEDQYTCRPQEHLMSNAFRNCVNRKH-VCDGMKDCPRGD 422
DG DC NG DE C+ V C + C R+CV + + CDG DC G
Sbjct: 502 DGQPDCLNGSDEEQCQEGVPCGTFTFQCED---------RSCVKKPNPQCDGRPDCRDGS 552
Query: 423 DEERC 427
DEE C
Sbjct: 553 DEEHC 557
Score = 70.5 bits (165), Expect = 5e-11
Identities = 45/118 (38%), Positives = 56/118 (47%), Gaps = 14/118 (11%)
Query: 267 DFECK-NTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCN-DGKCIPERWRCD 324
+F C N CVP CDG DC + DE +C C A F+C D CI CD
Sbjct: 452 EFLCSVNGLCVPA---CDGVKDCPNGLDERNCV-----CRA-TFQCKEDSTCISLPKVCD 502
Query: 325 NERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLK-TWLCDGVRDCTNGEDEMNCE 381
+ DC +G DE C+ C + C DR CV K CDG DC +G DE +C+
Sbjct: 503 GQPDCLNGSDEEQCQEGV--PCGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCD 558
Score = 39.9 bits (89), Expect = 0.081
Identities = 16/36 (44%), Positives = 22/36 (61%), Gaps = 1/36 (2%)
Query: 263 CAEIDFECKNTKCVPK-DFQCDGDNDCGDWTDEDSC 297
C F+C++ CV K + QCDG DC D +DE+ C
Sbjct: 522 CGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHC 557
Score = 38.7 bits (86), Expect = 0.19
Identities = 27/96 (28%), Positives = 37/96 (38%), Gaps = 11/96 (11%)
Query: 412 CDGMKDCPRGDDEERCPLKR--KCSAEEKC---EKLCITTYD---GHAACACPMGFLLAE 463
CDG+KDCP G DE C + +C + C K+C D G C G
Sbjct: 465 CDGVKDCPNGLDERNCVCRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGT 524
Query: 464 DKYSCRDIDECMYEQDPVCS--QTCSNTVGSFRCGC 497
+ C D C+ + +P C C + C C
Sbjct: 525 FTFQCED-RSCVKKPNPQCDGRPDCRDGSDEEHCDC 559
Score = 33.1 bits (72), Expect = 9.3
Identities = 13/29 (44%), Positives = 17/29 (58%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINC 195
C + CI+L +CDG DC + SDE C
Sbjct: 488 CKEDSTCISLPKVCDGQPDCLNGSDEEQC 516
>AY055384-1|AAL16414.1| 811|Homo sapiens type II transmembrane
serine protease 6 protein.
Length = 811
Score = 73.7 bits (173), Expect = 5e-12
Identities = 45/125 (36%), Positives = 58/125 (46%), Gaps = 22/125 (17%)
Query: 307 GEFKCN-DGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLC 365
GEF C+ +G C+P CD +DC +G DE NC + C D C+ +C
Sbjct: 460 GEFLCSVNGLCVPA---CDGVKDCPNGLDERNCVCRATFQCK------EDSTCISLPKVC 510
Query: 366 DGVRDCTNGEDEMNCE--VSCEEDQYTCRPQEHLMSNAFRNCVNRKH-VCDGMKDCPRGD 422
DG DC NG DE C+ V C + C R+CV + + CDG DC G
Sbjct: 511 DGQPDCLNGSDEEQCQEGVPCGTFTFQCED---------RSCVKKPNPQCDGRPDCRDGS 561
Query: 423 DEERC 427
DEE C
Sbjct: 562 DEEHC 566
Score = 70.5 bits (165), Expect = 5e-11
Identities = 45/118 (38%), Positives = 56/118 (47%), Gaps = 14/118 (11%)
Query: 267 DFECK-NTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCN-DGKCIPERWRCD 324
+F C N CVP CDG DC + DE +C C A F+C D CI CD
Sbjct: 461 EFLCSVNGLCVPA---CDGVKDCPNGLDERNCV-----CRA-TFQCKEDSTCISLPKVCD 511
Query: 325 NERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLK-TWLCDGVRDCTNGEDEMNCE 381
+ DC +G DE C+ C + C DR CV K CDG DC +G DE +C+
Sbjct: 512 GQPDCLNGSDEEQCQEGV--PCGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCD 567
Score = 39.9 bits (89), Expect = 0.081
Identities = 16/36 (44%), Positives = 22/36 (61%), Gaps = 1/36 (2%)
Query: 263 CAEIDFECKNTKCVPK-DFQCDGDNDCGDWTDEDSC 297
C F+C++ CV K + QCDG DC D +DE+ C
Sbjct: 531 CGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHC 566
Score = 38.7 bits (86), Expect = 0.19
Identities = 27/96 (28%), Positives = 37/96 (38%), Gaps = 11/96 (11%)
Query: 412 CDGMKDCPRGDDEERCPLKR--KCSAEEKC---EKLCITTYD---GHAACACPMGFLLAE 463
CDG+KDCP G DE C + +C + C K+C D G C G
Sbjct: 474 CDGVKDCPNGLDERNCVCRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGT 533
Query: 464 DKYSCRDIDECMYEQDPVCS--QTCSNTVGSFRCGC 497
+ C D C+ + +P C C + C C
Sbjct: 534 FTFQCED-RSCVKKPNPQCDGRPDCRDGSDEEHCDC 568
Score = 33.1 bits (72), Expect = 9.3
Identities = 13/29 (44%), Positives = 17/29 (58%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINC 195
C + CI+L +CDG DC + SDE C
Sbjct: 497 CKEDSTCISLPKVCDGQPDCLNGSDEEQC 525
>AY055383-1|AAL16413.1| 811|Homo sapiens type II transmembrane
serine protease 6 protein.
Length = 811
Score = 73.7 bits (173), Expect = 5e-12
Identities = 45/125 (36%), Positives = 58/125 (46%), Gaps = 22/125 (17%)
Query: 307 GEFKCN-DGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLC 365
GEF C+ +G C+P CD +DC +G DE NC + C D C+ +C
Sbjct: 460 GEFLCSVNGLCVPA---CDGVKDCPNGLDERNCVCRATFQCK------EDSTCISLPKVC 510
Query: 366 DGVRDCTNGEDEMNCE--VSCEEDQYTCRPQEHLMSNAFRNCVNRKH-VCDGMKDCPRGD 422
DG DC NG DE C+ V C + C R+CV + + CDG DC G
Sbjct: 511 DGQPDCLNGSDEEQCQEGVPCGTFTFQCED---------RSCVKKPNPQCDGRPDCRDGS 561
Query: 423 DEERC 427
DEE C
Sbjct: 562 DEEHC 566
Score = 70.5 bits (165), Expect = 5e-11
Identities = 45/118 (38%), Positives = 56/118 (47%), Gaps = 14/118 (11%)
Query: 267 DFECK-NTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCN-DGKCIPERWRCD 324
+F C N CVP CDG DC + DE +C C A F+C D CI CD
Sbjct: 461 EFLCSVNGLCVPA---CDGVKDCPNGLDERNCV-----CRA-TFQCKEDSTCISLPKVCD 511
Query: 325 NERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLK-TWLCDGVRDCTNGEDEMNCE 381
+ DC +G DE C+ C + C DR CV K CDG DC +G DE +C+
Sbjct: 512 GQPDCLNGSDEEQCQEGV--PCGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCD 567
Score = 39.9 bits (89), Expect = 0.081
Identities = 16/36 (44%), Positives = 22/36 (61%), Gaps = 1/36 (2%)
Query: 263 CAEIDFECKNTKCVPK-DFQCDGDNDCGDWTDEDSC 297
C F+C++ CV K + QCDG DC D +DE+ C
Sbjct: 531 CGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHC 566
Score = 38.7 bits (86), Expect = 0.19
Identities = 27/96 (28%), Positives = 37/96 (38%), Gaps = 11/96 (11%)
Query: 412 CDGMKDCPRGDDEERCPLKR--KCSAEEKC---EKLCITTYD---GHAACACPMGFLLAE 463
CDG+KDCP G DE C + +C + C K+C D G C G
Sbjct: 474 CDGVKDCPNGLDERNCVCRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGT 533
Query: 464 DKYSCRDIDECMYEQDPVCS--QTCSNTVGSFRCGC 497
+ C D C+ + +P C C + C C
Sbjct: 534 FTFQCED-RSCVKKPNPQCDGRPDCRDGSDEEHCDC 568
Score = 33.1 bits (72), Expect = 9.3
Identities = 13/29 (44%), Positives = 17/29 (58%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINC 195
C + CI+L +CDG DC + SDE C
Sbjct: 497 CKEDSTCISLPKVCDGQPDCLNGSDEEQC 525
>AY004330-1|AAK11491.1| 493|Homo sapiens EGF-containing
fibulin-like extracellular matrix protein 1 protein.
Length = 493
Score = 73.7 bits (173), Expect = 5e-12
Identities = 48/161 (29%), Positives = 72/161 (44%), Gaps = 13/161 (8%)
Query: 366 DGVRDCTNGEDEMNCEVSCEEDQYT-CRPQEHLMSNAFRNCVNRKHVCDGMK-----DCP 419
D R +N + C E+ ++ C+ + + NC VC ++ CP
Sbjct: 145 DPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGT-HNC-RADQVCINLRGSFACQCP 202
Query: 420 RGDDE--ERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYE 477
G + E+C +C+ C + C+ T G C C GF LA + Y+C DI+EC +
Sbjct: 203 PGYQKRGEQCVDIDECTIPPYCHQRCVNT-PGSFYCQCSPGFQLAANNYTCVDINEC--D 259
Query: 478 QDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPT 518
C+Q C N +GSF C C GY L D +C+ E T
Sbjct: 260 ASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT 300
Score = 49.2 bits (112), Expect = 1e-04
Identities = 41/159 (25%), Positives = 62/159 (38%), Gaps = 15/159 (9%)
Query: 371 CTNGEDEMNCEVS----CEEDQYTCRP-QEHLMSN-AFRNCVN--RKHVCDGMKDCPRGD 422
C N C+ S + YTC E SN + C N +C +
Sbjct: 228 CVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSS 287
Query: 423 DEERCPLKRKC-SAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV 481
D C +C ++ C+ C+ G +C CP G+ + + +C+DI+EC +
Sbjct: 288 DRLNCEDIDECRTSSYLCQYQCVNE-PGKFSCMCPQGYQVVRSR-TCQDINECETTNECR 345
Query: 482 CSQTCSNTVGSFRC----GCMTGYILRPDERSCKPTGES 516
+ C N G FRC C YIL P+ R P +
Sbjct: 346 EDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNA 384
Score = 34.3 bits (75), Expect = 4.0
Identities = 14/46 (30%), Positives = 23/46 (50%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPE 1367
C T + C + C+ P ++C CP G +S T Q +C++ E
Sbjct: 298 CRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNE 343
>AL022314-2|CAI19335.1| 788|Homo sapiens protein ( Human DNA
sequence from clone RP5-1170K4 on chromosome
22q12.2-13.1.1. ).
Length = 788
Score = 73.7 bits (173), Expect = 5e-12
Identities = 45/125 (36%), Positives = 58/125 (46%), Gaps = 22/125 (17%)
Query: 307 GEFKCN-DGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLC 365
GEF C+ +G C+P CD +DC +G DE NC + C D C+ +C
Sbjct: 437 GEFLCSVNGLCVPA---CDGVKDCPNGLDERNCVCRATFQCK------EDSTCISLPKVC 487
Query: 366 DGVRDCTNGEDEMNCE--VSCEEDQYTCRPQEHLMSNAFRNCVNRKH-VCDGMKDCPRGD 422
DG DC NG DE C+ V C + C R+CV + + CDG DC G
Sbjct: 488 DGQPDCLNGSDEEQCQEGVPCGTFTFQCED---------RSCVKKPNPQCDGRPDCRDGS 538
Query: 423 DEERC 427
DEE C
Sbjct: 539 DEEHC 543
Score = 70.5 bits (165), Expect = 5e-11
Identities = 45/118 (38%), Positives = 56/118 (47%), Gaps = 14/118 (11%)
Query: 267 DFECK-NTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCN-DGKCIPERWRCD 324
+F C N CVP CDG DC + DE +C C A F+C D CI CD
Sbjct: 438 EFLCSVNGLCVPA---CDGVKDCPNGLDERNCV-----CRA-TFQCKEDSTCISLPKVCD 488
Query: 325 NERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLK-TWLCDGVRDCTNGEDEMNCE 381
+ DC +G DE C+ C + C DR CV K CDG DC +G DE +C+
Sbjct: 489 GQPDCLNGSDEEQCQEGV--PCGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCD 544
Score = 39.9 bits (89), Expect = 0.081
Identities = 16/36 (44%), Positives = 22/36 (61%), Gaps = 1/36 (2%)
Query: 263 CAEIDFECKNTKCVPK-DFQCDGDNDCGDWTDEDSC 297
C F+C++ CV K + QCDG DC D +DE+ C
Sbjct: 508 CGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHC 543
Score = 38.7 bits (86), Expect = 0.19
Identities = 27/96 (28%), Positives = 37/96 (38%), Gaps = 11/96 (11%)
Query: 412 CDGMKDCPRGDDEERCPLKR--KCSAEEKC---EKLCITTYD---GHAACACPMGFLLAE 463
CDG+KDCP G DE C + +C + C K+C D G C G
Sbjct: 451 CDGVKDCPNGLDERNCVCRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGT 510
Query: 464 DKYSCRDIDECMYEQDPVCS--QTCSNTVGSFRCGC 497
+ C D C+ + +P C C + C C
Sbjct: 511 FTFQCED-RSCVKKPNPQCDGRPDCRDGSDEEHCDC 545
Score = 33.1 bits (72), Expect = 9.3
Identities = 13/29 (44%), Positives = 17/29 (58%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINC 195
C + CI+L +CDG DC + SDE C
Sbjct: 474 CKEDSTCISLPKVCDGQPDCLNGSDEEQC 502
>AK129963-1|BAC85262.1| 284|Homo sapiens protein ( Homo sapiens
cDNA FLJ26453 fis, clone KDN03319, highly similar to
Homo sapiens immunoglobulin superfamily, member 1
(IGSF1). ).
Length = 284
Score = 73.7 bits (173), Expect = 5e-12
Identities = 35/92 (38%), Positives = 52/92 (56%), Gaps = 12/92 (13%)
Query: 303 SCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCK------PNSIRNCSLDEYTCA-- 354
SC A EF+C++GKC+P W+C+ +C DG DE NC P S+ C + C+
Sbjct: 39 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSL--CPGGTFPCSGA 96
Query: 355 -DRRCVLKTWLCDGVRDCTNGEDEMNC-EVSC 384
RC+ CDG++DC +G DE C +++C
Sbjct: 97 RSTRCLPVERRCDGLQDCGDGSDEAGCPDLAC 128
Score = 73.3 bits (172), Expect = 7e-12
Identities = 34/84 (40%), Positives = 46/84 (54%), Gaps = 8/84 (9%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPM----VPGS-CNAGEFKCNDG--- 314
C +F C N KC+P +QC+ ++CGD +DE +C PGS C G F C+
Sbjct: 40 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARST 99
Query: 315 KCIPERWRCDNERDCADGGDELNC 338
+C+P RCD +DC DG DE C
Sbjct: 100 RCLPVERRCDGLQDCGDGSDEAGC 123
Score = 62.9 bits (146), Expect = 1e-08
Identities = 28/86 (32%), Positives = 43/86 (50%), Gaps = 2/86 (2%)
Query: 345 NCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRN 404
+C DE+ C + +C+ W C+ V +C +G DE NC E + P + R+
Sbjct: 39 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARS 98
Query: 405 --CVNRKHVCDGMKDCPRGDDEERCP 428
C+ + CDG++DC G DE CP
Sbjct: 99 TRCLPVERRCDGLQDCGDGSDEAGCP 124
Score = 42.3 bits (95), Expect = 0.015
Identities = 16/39 (41%), Positives = 24/39 (61%)
Query: 271 KNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEF 309
++T+C+P + +CDG DCGD +DE CP + G F
Sbjct: 97 RSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSF 135
Score = 34.3 bits (75), Expect = 4.0
Identities = 13/23 (56%), Positives = 15/23 (65%)
Query: 173 CIALEWLCDGDNDCGDFSDEINC 195
C+ +E CDG DCGD SDE C
Sbjct: 101 CLPVERRCDGLQDCGDGSDEAGC 123
>AJ319876-1|CAC85953.1| 802|Homo sapiens matriptase-2 protein.
Length = 802
Score = 73.7 bits (173), Expect = 5e-12
Identities = 45/125 (36%), Positives = 58/125 (46%), Gaps = 22/125 (17%)
Query: 307 GEFKCN-DGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLC 365
GEF C+ +G C+P CD +DC +G DE NC + C D C+ +C
Sbjct: 451 GEFLCSVNGLCVPA---CDGVKDCPNGLDERNCVCRATFQCK------EDSTCISLPKVC 501
Query: 366 DGVRDCTNGEDEMNCE--VSCEEDQYTCRPQEHLMSNAFRNCVNRKH-VCDGMKDCPRGD 422
DG DC NG DE C+ V C + C R+CV + + CDG DC G
Sbjct: 502 DGQPDCLNGSDEEQCQEGVPCGTFTFQCED---------RSCVKKPNPQCDGRPDCRDGS 552
Query: 423 DEERC 427
DEE C
Sbjct: 553 DEEHC 557
Score = 70.5 bits (165), Expect = 5e-11
Identities = 45/118 (38%), Positives = 56/118 (47%), Gaps = 14/118 (11%)
Query: 267 DFECK-NTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCN-DGKCIPERWRCD 324
+F C N CVP CDG DC + DE +C C A F+C D CI CD
Sbjct: 452 EFLCSVNGLCVPA---CDGVKDCPNGLDERNCV-----CRA-TFQCKEDSTCISLPKVCD 502
Query: 325 NERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLK-TWLCDGVRDCTNGEDEMNCE 381
+ DC +G DE C+ C + C DR CV K CDG DC +G DE +C+
Sbjct: 503 GQPDCLNGSDEEQCQEGV--PCGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCD 558
Score = 39.9 bits (89), Expect = 0.081
Identities = 16/36 (44%), Positives = 22/36 (61%), Gaps = 1/36 (2%)
Query: 263 CAEIDFECKNTKCVPK-DFQCDGDNDCGDWTDEDSC 297
C F+C++ CV K + QCDG DC D +DE+ C
Sbjct: 522 CGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHC 557
Score = 38.7 bits (86), Expect = 0.19
Identities = 27/96 (28%), Positives = 37/96 (38%), Gaps = 11/96 (11%)
Query: 412 CDGMKDCPRGDDEERCPLKR--KCSAEEKC---EKLCITTYD---GHAACACPMGFLLAE 463
CDG+KDCP G DE C + +C + C K+C D G C G
Sbjct: 465 CDGVKDCPNGLDERNCVCRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGT 524
Query: 464 DKYSCRDIDECMYEQDPVCS--QTCSNTVGSFRCGC 497
+ C D C+ + +P C C + C C
Sbjct: 525 FTFQCED-RSCVKKPNPQCDGRPDCRDGSDEEHCDC 559
Score = 33.1 bits (72), Expect = 9.3
Identities = 13/29 (44%), Positives = 17/29 (58%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINC 195
C + CI+L +CDG DC + SDE C
Sbjct: 488 CKEDSTCISLPKVCDGQPDCLNGSDEEQC 516
>AB209212-1|BAD92449.1| 418|Homo sapiens EGF-containing
fibulin-like extracellular matrix protein 1 isoform b
variant protein.
Length = 418
Score = 73.7 bits (173), Expect = 5e-12
Identities = 48/161 (29%), Positives = 72/161 (44%), Gaps = 13/161 (8%)
Query: 366 DGVRDCTNGEDEMNCEVSCEEDQYT-CRPQEHLMSNAFRNCVNRKHVCDGMK-----DCP 419
D R +N + C E+ ++ C+ + + NC VC ++ CP
Sbjct: 70 DPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGT-HNC-RADQVCINLRGSFACQCP 127
Query: 420 RGDDE--ERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYE 477
G + E+C +C+ C + C+ T G C C GF LA + Y+C DI+EC +
Sbjct: 128 PGYQKRGEQCVDIDECTIPPYCHQRCVNT-PGSFYCQCSPGFQLAANNYTCVDINEC--D 184
Query: 478 QDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPT 518
C+Q C N +GSF C C GY L D +C+ E T
Sbjct: 185 ASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT 225
Score = 49.2 bits (112), Expect = 1e-04
Identities = 41/159 (25%), Positives = 62/159 (38%), Gaps = 15/159 (9%)
Query: 371 CTNGEDEMNCEVS----CEEDQYTCRP-QEHLMSN-AFRNCVN--RKHVCDGMKDCPRGD 422
C N C+ S + YTC E SN + C N +C +
Sbjct: 153 CVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSS 212
Query: 423 DEERCPLKRKC-SAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV 481
D C +C ++ C+ C+ G +C CP G+ + + +C+DI+EC +
Sbjct: 213 DRLNCEDIDECRTSSYLCQYQCVNQ-PGKFSCMCPQGYQVVRSR-TCQDINECETTNECR 270
Query: 482 CSQTCSNTVGSFRC----GCMTGYILRPDERSCKPTGES 516
+ C N G FRC C YIL P+ R P +
Sbjct: 271 EDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNA 309
Score = 34.3 bits (75), Expect = 4.0
Identities = 14/46 (30%), Positives = 23/46 (50%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPE 1367
C T + C + C+ P ++C CP G +S T Q +C++ E
Sbjct: 223 CRTSSYLCQYQCVNQPGKFSCMCPQGYQVVRSRTCQDINECETTNE 268
>U03272-1|AAA18950.1| 2911|Homo sapiens fibrillin-2 protein.
Length = 2911
Score = 72.1 bits (169), Expect = 2e-11
Identities = 81/301 (26%), Positives = 121/301 (40%), Gaps = 48/301 (15%)
Query: 258 VELMRCAEIDFECKNTKCVPK--DFQC------DGDNDCGDWTDEDSCPMVPGSCNA--- 306
V++ C+ D C+N KCV +QC D TD D C ++ G C+
Sbjct: 1198 VDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCT 1257
Query: 307 ---GEFKCN---------DGKCIPERWRCDNERDCADGGD------ELNCKPNSIRNCSL 348
G ++C+ DG+ + C+N D DGG E C S+
Sbjct: 1258 NSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASM 1317
Query: 349 DEYTCAD-RRCVLKTWLC-DGVRDCTNGEDEMNCEV--SCEEDQYTCRPQEHLMSNAFRN 404
D TC D C L + +C G + T G +C++ S ++ C + A N
Sbjct: 1318 DMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGA-HN 1376
Query: 405 C---VNRKHVCDGMK-DCPRG--DDEERCPLKRKCS-AEEKC--EKLCITTYDGHAACAC 455
C + ++ K C G + +C +CS +C C+ T G CAC
Sbjct: 1377 CDMHASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNT-PGSYRCAC 1435
Query: 456 PMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGYILRPDERSCKPTG 514
GF D ++C D+DEC E +C C N G++RC C G+ D RSC+
Sbjct: 1436 SEGF--TGDGFTCSDVDECA-ENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDID 1492
Query: 515 E 515
E
Sbjct: 1493 E 1493
Score = 72.1 bits (169), Expect = 2e-11
Identities = 80/275 (29%), Positives = 103/275 (37%), Gaps = 42/275 (15%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
CA+ID EC+N + CDG C + E C G + + K CI
Sbjct: 1280 CADID-ECENNPDI-----CDG-GQCTNIPGEYRCLCYDGFMASMDMKT----CIDVN-E 1327
Query: 323 CD-NERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCE 381
CD N C G E N K + I +C L Y+ T C V +C G +
Sbjct: 1328 CDLNSNICMFGECE-NTKGSFICHCQLG-YSVKKG-----TTGCTDVDECEIGAHNCDMH 1380
Query: 382 VSCEE--DQYTCRPQEHLMSNAFR-----NCVNRKHVCDGMKDCPRGDDEERCPLKR--- 431
SC + C +E + N + C N H C C RC
Sbjct: 1381 ASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFT 1440
Query: 432 ----KCSAEEKCEK---LC----ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP 480
CS ++C + LC G C C MGF A D SC+DIDEC + Q+
Sbjct: 1441 GDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSF-QNI 1499
Query: 481 VCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
S TC+N G F C C GY L +C E
Sbjct: 1500 CVSGTCNNLPGMFHCICDDGYELDRTGGNCTDIDE 1534
Score = 71.7 bits (168), Expect = 2e-11
Identities = 57/217 (26%), Positives = 86/217 (39%), Gaps = 25/217 (11%)
Query: 303 SCNAGEFKCNDGKCIPERWRCDNERD-----CAD--GGDELNCKPNSIRNCSLDEYTCAD 355
SC G DGK + C ++ C + GG C P ++ + C D
Sbjct: 2515 SCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHT----ACID 2570
Query: 356 RR-CVLKTWLCDGVRDCTNGEDEMNCEV----SCEEDQYTCRPQEHLMSNAFRNCVNR-K 409
C + LC G C N +CE S + C + N C + +
Sbjct: 2571 NNECGSQPLLCGGKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGN--HRCQHGCQ 2628
Query: 410 HVCDGMK-DCPRGDDEE----RCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAED 464
++ G + CP+G + +C + +CS C G CACP GF +
Sbjct: 2629 NILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQF 2688
Query: 465 KYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGY 501
+C D++EC ++P C+ CSNT G + CGC GY
Sbjct: 2689 SSACHDVNECSSSKNP-CNYGCSNTEGGYLCGCPPGY 2724
Score = 67.7 bits (158), Expect = 4e-10
Identities = 73/260 (28%), Positives = 98/260 (37%), Gaps = 34/260 (13%)
Query: 278 KDFQCDGDNDCGDWTDEDSCPMVPGSCN--AGEFKCNDGKCIPERWRCDNERDCADGGDE 335
K C N+C DED + GSC G F+C C P DN R C D
Sbjct: 2049 KSENCIDINEC----DEDPNICLFGSCTNTPGGFQC---LCPPGFVLSDNGRRCFDTRQS 2101
Query: 336 LNCKPNSIRNCSLDE-YTCADRRCVLKTWLCDGVRD----CTNGEDEMNCEVSCEEDQYT 390
CS+ + + +C +G D C +DE+ + C T
Sbjct: 2102 FCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPK-DDEVAFQDLCPYGHGT 2160
Query: 391 CRPQEHLMSNAFRNCVNRKHVC--------DGMK--DCPRGDDEE----RCPLKRKCSAE 436
P H C+ +C DG +CP G + + RC +CS
Sbjct: 2161 V-PSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIG 2219
Query: 437 EKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV-CSQTCSNTVGSFRC 495
C T G C C GF +C DI+EC Q+P+ C+ C NT GS+ C
Sbjct: 2220 NPCGNGTCTNVIGSFECNCNEGFEPGP-MMNCEDINECA--QNPLLCALRCMNTFGSYEC 2276
Query: 496 GCMTGYILRPDERSCKPTGE 515
C GY LR D++ CK E
Sbjct: 2277 TCPIGYALREDQKMCKDLDE 2296
Score = 66.9 bits (156), Expect = 6e-10
Identities = 64/255 (25%), Positives = 95/255 (37%), Gaps = 22/255 (8%)
Query: 269 ECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCI--PERWRCDNE 326
+C+NT F+C ++ +E +C + C C G C+ P + C+
Sbjct: 1087 KCRNTI---GSFKCRCNSGFALDMEERNCTDID-ECRISPDLCGSGICVNTPGSFECECF 1142
Query: 327 RDCADGGDEL-NCKPNSIRNCSLDEYTCADRRCVLK--TWLCDGVRDCTNGEDEMNCEVS 383
G + NC I C + C CV ++ CD C G +
Sbjct: 1143 EGYESGFMMMKNCM--DIDGCERNPLLCRGGTCVNTEGSFQCD----CPLGHELSPSRED 1196
Query: 384 CEEDQYTCRPQEHLMSNAFRNCVNR--KHVCDGMKDCPRGDDEERCPLKRKCSAEEK-CE 440
C D C ++L N CVN + C D + C +C C+
Sbjct: 1197 CV-DINECSLSDNLCRNG--KCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCD 1253
Query: 441 KLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTG 500
C T +G C+C G+ L D SC DIDEC D C+N G +RC C G
Sbjct: 1254 TQC-TNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDG 1312
Query: 501 YILRPDERSCKPTGE 515
++ D ++C E
Sbjct: 1313 FMASMDMKTCIDVNE 1327
Score = 65.7 bits (153), Expect = 1e-09
Identities = 30/76 (39%), Positives = 40/76 (52%), Gaps = 2/76 (2%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
CI T G C C +G+ SC D+DEC P C+ C NT GS++C C GY+
Sbjct: 2464 CINTM-GSFRCFCKVGYTTDISGTSCIDLDECSQSPKP-CNYICKNTEGSYQCSCPRGYV 2521
Query: 503 LRPDERSCKPTGESPT 518
L+ D ++CK E T
Sbjct: 2522 LQEDGKTCKDLDECQT 2537
Score = 64.9 bits (151), Expect = 2e-09
Identities = 29/71 (40%), Positives = 41/71 (57%), Gaps = 3/71 (4%)
Query: 432 KCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTV 490
+CS K C +C T +G C+CP G++L ED +C+D+DEC +Q C C NT+
Sbjct: 2493 ECSQSPKPCNYICKNT-EGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHN-CQFLCVNTL 2550
Query: 491 GSFRCGCMTGY 501
G F C C G+
Sbjct: 2551 GGFTCKCPPGF 2561
Score = 63.7 bits (148), Expect = 6e-09
Identities = 61/258 (23%), Positives = 95/258 (36%), Gaps = 30/258 (11%)
Query: 270 CKNTKCVPKDFQCDG-DNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPER--WRCDNE 326
C NT P F+C+ + + +C + G C C G C+ ++CD
Sbjct: 1130 CVNT---PGSFECECFEGYESGFMMMKNCMDIDG-CERNPLLCRGGTCVNTEGSFQCDCP 1185
Query: 327 RDCADGGDELNCKPNSIRNCSLDEYTCADRRCV--LKTWLCDGVRDCTNGEDEMNCEVSC 384
+C I CSL + C + +CV + T+ C C G C
Sbjct: 1186 LGHELSPSREDCV--DINECSLSDNLCRNGKCVNMIGTYQCS----CNPGYQATPDRQGC 1239
Query: 385 EEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEK--- 441
+ E ++ N C + +G +C + P R C+ ++CE
Sbjct: 1240 TDID------ECMIMNG--GCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPD 1291
Query: 442 LC----ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGC 497
+C T G C C GF+ + D +C D++EC + C NT GSF C C
Sbjct: 1292 ICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHC 1351
Query: 498 MTGYILRPDERSCKPTGE 515
GY ++ C E
Sbjct: 1352 QLGYSVKKGTTGCTDVDE 1369
Score = 62.9 bits (146), Expect = 1e-08
Identities = 78/280 (27%), Positives = 112/280 (40%), Gaps = 48/280 (17%)
Query: 263 CAEIDFECKNTKC--VPKDFQCDGD------NDCGDWTDEDSCPM----VPGSCN--AGE 308
CAE C+N +C VP ++C+ + +D D D C V G+CN G
Sbjct: 1452 CAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVSGTCNNLPGM 1511
Query: 309 FKC--NDGKCIPERW-RCDNERDCAD-------------GGDELNCKPNSIRNCSLDEYT 352
F C +DG + C + +CAD G E NC P+ N +
Sbjct: 1512 FHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPT--GVG 1569
Query: 353 CADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ-EHLMSNAFRNCVNRKHV 411
C D R V +L G R +G N E+ + +C N C
Sbjct: 1570 CVDNR-VGNCYLKFGPRG--DGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNST 1626
Query: 412 CDGMKDCPRGDDEERCPLKRKCSAEEKCEKL--------CITTYDGHAACACPMGFLLAE 463
+ CP G+ P+ ++C++L CI T+ G C CP G+ L+E
Sbjct: 1627 -EYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTF-GSFQCECPQGYYLSE 1684
Query: 464 DKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGYI 502
D C DIDEC + VC TC NT+G++ C C Y+
Sbjct: 1685 DTRICEDIDEC-FAHPGVCGPGTCYNTLGNYTCICPPEYM 1723
Score = 62.5 bits (145), Expect = 1e-08
Identities = 30/82 (36%), Positives = 40/82 (48%), Gaps = 3/82 (3%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ--TCSNTVGSFRCG 496
C C+ T+ G C CP+G+ L ED+ C+D+DEC S+ C N +G+F C
Sbjct: 2263 CALRCMNTF-GSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCI 2321
Query: 497 CMTGYILRPDERSCKPTGESPT 518
C G RPD C E T
Sbjct: 2322 CPPGMARRPDGEGCVDENECRT 2343
Score = 59.3 bits (137), Expect = 1e-07
Identities = 46/166 (27%), Positives = 60/166 (36%), Gaps = 12/166 (7%)
Query: 364 LCDGVRDCTNGEDEMNCEVSCE---------EDQYTCRPQEHLMSNAFRNCVNRKHVCDG 414
LC DC N CE + D+ C ++ S+ + + C
Sbjct: 1859 LCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCIC 1918
Query: 415 MKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
D+ C +C C T G C C GF L + C DIDEC
Sbjct: 1919 HNGFKASQDQTMCMDVDECERHPCGNGTCKNTV-GSYNCLCYPGFELTHNN-DCLDIDEC 1976
Query: 475 MYEQDPVCSQ-TCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTL 519
VC C N +GSF+C C GY L PD ++C T E L
Sbjct: 1977 SSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVAL 2022
Score = 59.3 bits (137), Expect = 1e-07
Identities = 59/231 (25%), Positives = 87/231 (37%), Gaps = 22/231 (9%)
Query: 297 CPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADR 356
CP PG G ++ K +P C N + C + C + +C D
Sbjct: 2436 CPHGPGYTTDGR-DIDECKVMPNL--CTNGQ-CINTMGSFRCFCKVGYTTDISGTSCIDL 2491
Query: 357 -RCVLKTWLCDGVRDCTNGEDEMNCEVS--CEEDQYTCRPQEHLMS---NAFRNCVNRKH 410
C C+ + T G + +C +ED TC+ + + N CVN
Sbjct: 2492 DECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVN--- 2548
Query: 411 VCDGMK-DCPRGDDEER--CPLKRKCSAEEK-C--EKLCITTYDGHAACACPMGFLLAED 464
G CP G + C +C ++ C + +C T G +C C GF L
Sbjct: 2549 TLGGFTCKCPPGFTQHHTACIDNNECGSQPLLCGGKGICQNT-PGSFSCECQRGFSLDAT 2607
Query: 465 KYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
+C D+DEC + + C C N +G +RCGC GYI C E
Sbjct: 2608 GLNCEDVDEC--DGNHRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENE 2656
Score = 58.8 bits (136), Expect = 2e-07
Identities = 33/93 (35%), Positives = 45/93 (48%), Gaps = 5/93 (5%)
Query: 423 DEERCPLKRKCSAEEKC-EKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV 481
D + C +C+ C +CI DG C C GF+LA + C D+DEC + +
Sbjct: 610 DGKNCVDHDECTTTNMCLNGMCINE-DGSFKCICKPGFVLAPNGRYCTDVDEC--QTPGI 666
Query: 482 C-SQTCSNTVGSFRCGCMTGYILRPDERSCKPT 513
C + C N+ GSFRC C G + D R C T
Sbjct: 667 CMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDT 699
Score = 57.2 bits (132), Expect = 5e-07
Identities = 45/149 (30%), Positives = 61/149 (40%), Gaps = 15/149 (10%)
Query: 380 CEVSCEEDQY-TCRPQEHLMSNAFRN--CVNRKHVCDGMKDCPRGDDEERCPLKRKCSAE 436
C + ++D C + SN N CVN G C +R P K+ C
Sbjct: 520 CNMGYKQDANGDCIDVDECTSNPCTNGDCVNTP----GSYYCKCHAGFQRTPTKQACIDI 575
Query: 437 EKCEK---LC----ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNT 489
++C + LC DG C C GF L D +C D DEC + + C N
Sbjct: 576 DECIQNGVLCKNGRCVNSDGSFQCICNAGFELTTDGKNCVDHDECT-TTNMCLNGMCINE 634
Query: 490 VGSFRCGCMTGYILRPDERSCKPTGESPT 518
GSF+C C G++L P+ R C E T
Sbjct: 635 DGSFKCICKPGFVLAPNGRYCTDVDECQT 663
Score = 57.2 bits (132), Expect = 5e-07
Identities = 76/353 (21%), Positives = 113/353 (32%), Gaps = 22/353 (6%)
Query: 163 NRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTV 222
+R C + C+ + CD C + C + L+P + +I + NP +
Sbjct: 1235 DRQGCTDIDECMIMNGGCD--TQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDI 1292
Query: 223 LIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQC 282
+ Y C + + +L + EC+NTK F C
Sbjct: 1293 CDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTK---GSFIC 1349
Query: 283 DGDNDCGDWTDEDSCPMVPGSCNAGEFKCN-DGKC--IPERWRCDNERDCADGGDELNCK 339
C V C G C+ C IP ++C C +G K
Sbjct: 1350 HCQLGYSVKKGTTGCTDVD-ECEIGAHNCDMHASCLNIPGSFKCS----CREGWIGNGIK 1404
Query: 340 PNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMS 399
+ CS + C+ + T G C E +C D C +L
Sbjct: 1405 CIDLDECSNGTHQCSINAQCVNT---PGSYRCACSEGFTGDGFTCS-DVDECAENINLCE 1460
Query: 400 NAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGF 459
N V + C+ D C +CS + C G C C G+
Sbjct: 1461 NGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVSGTCNNLPGMFHCICDDGY 1520
Query: 460 LLAEDKYSCRDIDECMYEQDPV-C-SQTCSNTVGSFRCGCMTGYILRPDERSC 510
L +C DIDEC DP+ C + C NT G + C C + L P C
Sbjct: 1521 ELDRTGGNCTDIDEC---ADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGC 1570
Score = 56.8 bits (131), Expect = 7e-07
Identities = 28/68 (41%), Positives = 32/68 (47%), Gaps = 1/68 (1%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
CI T G C CP G +E C DIDEC + CSNTVGS+ C C GY+
Sbjct: 291 CINTV-GSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYV 349
Query: 503 LRPDERSC 510
D C
Sbjct: 350 TSTDGSRC 357
Score = 55.2 bits (127), Expect = 2e-06
Identities = 72/275 (26%), Positives = 107/275 (38%), Gaps = 35/275 (12%)
Query: 260 LMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND-GKCIP 318
L+ C +ID EC N D C + DC + C G + C D +C+
Sbjct: 1844 LLVCEDID-ECSNG-----DNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLE 1897
Query: 319 ERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDE 377
C + C D C ++ S D+ C D C + C G C N
Sbjct: 1898 IPNVCSHGL-CVDLQGSYQCICHNGFKASQDQTMCMDVDEC--ERHPC-GNGTCKNTVGS 1953
Query: 378 MNC------EVSCEEDQYTCRPQEHLMSNAFRN--CVNR----KHVC-DGMKDCPRGDDE 424
NC E++ D RN C N K +C +G + P G
Sbjct: 1954 YNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDG--- 2010
Query: 425 ERCPLKRKCSA-EEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VC 482
+ C +C A C +G C CP G+ + + +C DI+EC ++DP +C
Sbjct: 2011 KNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSE--NCIDINEC--DEDPNIC 2066
Query: 483 S-QTCSNTVGSFRCGCMTGYILRPDERSCKPTGES 516
+C+NT G F+C C G++L + R C T +S
Sbjct: 2067 LFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQS 2101
Score = 54.8 bits (126), Expect = 3e-06
Identities = 60/225 (26%), Positives = 81/225 (36%), Gaps = 27/225 (12%)
Query: 292 TDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEY 351
TD D C PG C G ++G +RCD A G D C +R+
Sbjct: 656 TDVDEC-QTPGICMNGHCINSEGS-----FRCDCPPGLAVGMDGRVCVDTHMRS------ 703
Query: 352 TCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHV 411
TC +K +C VR + C C Y E +N +
Sbjct: 704 TCYGG---IKKGVC--VRPFPGAVTKSEC--CCANPDYGFG--EPCQPCPAKNSAEFHGL 754
Query: 412 CD-GMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRD 470
C G+ G D C L A CE L G C C G+ +C D
Sbjct: 755 CSSGVGITVDGRDINECALDPDICANGICENL-----RGSYRCNCNSGYEPDASGRNCID 809
Query: 471 IDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
IDEC+ + + C NT GS+ C C GY+ R + +C+ E
Sbjct: 810 IDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINE 854
Score = 54.4 bits (125), Expect = 4e-06
Identities = 75/295 (25%), Positives = 110/295 (37%), Gaps = 43/295 (14%)
Query: 258 VELMRCAEIDFECK-NTKCV--PKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDG 314
++L C+ +C N +CV P ++C G D +C V C C +G
Sbjct: 1406 IDLDECSNGTHQCSINAQCVNTPGSYRCACSE--GFTGDGFTCSDVD-ECAENINLCENG 1462
Query: 315 KC--IPERWRCDNERDCADGGDELNCKPNSIRNCSLDEY----TCADRRCVLKTWLCDGV 368
+C +P +RC+ E D +C+ I CS TC + + DG
Sbjct: 1463 QCLNVPGAYRCECEMGFTPASDSRSCQ--DIDECSFQNICVSGTCNNLPGMFHCICDDGY 1520
Query: 369 R-DCTNGE----DEMNCEVSCEED-------QYTCR-PQEHLMSNAFRNCVNRKHVCDGM 415
D T G DE ++C +Y C P + ++ CV+ + +
Sbjct: 1521 ELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYL 1580
Query: 416 KDCPRGDDEERCP------LKRK---CSAEEKCEKLC-----ITTYDGHAACACPMGFLL 461
K PRGD C + R CS + C + + + + C GF
Sbjct: 1581 KFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRP 1640
Query: 462 AEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
DIDEC E +C C NT GSF+C C GY L D R C+ E
Sbjct: 1641 NPITIILEDIDECQ-ELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDE 1694
Score = 52.4 bits (120), Expect = 1e-05
Identities = 23/59 (38%), Positives = 32/59 (54%), Gaps = 3/59 (5%)
Query: 442 LCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTG 500
LC T G +C CP G++ + +C DI+EC E +P + C N +GSF C C G
Sbjct: 824 LCRNT-PGSYSCTCPPGYVFRTETETCEDINEC--ESNPCVNGACRNNLGSFNCECSPG 879
Score = 52.0 bits (119), Expect = 2e-05
Identities = 60/258 (23%), Positives = 96/258 (37%), Gaps = 37/258 (14%)
Query: 290 DWTDEDSCPMVPGSCNAGEFKCNDG--KCIPE-RWRCD-NERDCADGGDELNCKP---NS 342
D D D C ++P C G+ G +C + + D + C D DE + P N
Sbjct: 2445 DGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDL-DECSQSPKPCNY 2503
Query: 343 IRNCSLDEYTCA-DRRCVLKT--WLCDGVRDCTNGEDEMNCEVSCEEDQ--YTCR----- 392
I + Y C+ R VL+ C + +C + NC+ C +TC+
Sbjct: 2504 ICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQH--NCQFLCVNTLGGFTCKCPPGF 2561
Query: 393 PQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKR---------------KCSAEE 437
Q H C ++ +C G C C +R +C
Sbjct: 2562 TQHHTACIDNNECGSQPLLCGGKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNH 2621
Query: 438 KCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGC 497
+C+ C G+ C CP G++ C D +EC + S +C NT+GS++C C
Sbjct: 2622 RCQHGCQNILGGYR-CGCPQGYIQHYQWNQCVDENECS-NPNACGSASCYNTLGSYKCAC 2679
Query: 498 MTGYILRPDERSCKPTGE 515
+G+ +C E
Sbjct: 2680 PSGFSFDQFSSACHDVNE 2697
Score = 50.4 bits (115), Expect = 6e-05
Identities = 26/67 (38%), Positives = 34/67 (50%), Gaps = 4/67 (5%)
Query: 442 LCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQT--CSNTVGSFRCGCMT 499
+CI G C CP GF + C DIDEC D +C + C N+ GS+RC C
Sbjct: 1822 VCINQI-GSFRCECPTGFSYNDLLLVCEDIDECS-NGDNLCQRNADCINSPGSYRCECAA 1879
Query: 500 GYILRPD 506
G+ L P+
Sbjct: 1880 GFKLSPN 1886
Score = 47.2 bits (107), Expect = 5e-04
Identities = 51/221 (23%), Positives = 76/221 (34%), Gaps = 16/221 (7%)
Query: 294 EDSCPMVPGSCNAGEFKCND-GKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYT 352
+D CP G+ + D +C+ C N + C + C+ N
Sbjct: 2151 QDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQ-CINTDGSFRCECPMGYNLDYTGVR 2209
Query: 353 CADR-RCVLKTWLCDGVRDCTN--GEDEMNCEVSCEED-QYTCRPQEHLMSNAFRNCVNR 408
C D C + +G CTN G E NC E C N +
Sbjct: 2210 CVDTDECSIGNPCGNGT--CTNVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCALRC 2267
Query: 409 KHVCDGMK-DCPRG----DDEERCPLKRKCSAE-EKCEK--LCITTYDGHAACACPMGFL 460
+ + CP G +D++ C +C+ CE + G C CP G
Sbjct: 2268 MNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMA 2327
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGY 501
D C D +EC + + C N +GS+RC C G+
Sbjct: 2328 RRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGF 2368
Score = 45.2 bits (102), Expect = 0.002
Identities = 47/176 (26%), Positives = 58/176 (32%), Gaps = 12/176 (6%)
Query: 338 CKPNSIRNCSLDEYTCADRR-CVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEH 396
C P R D C D C K +C+ R C N CE C E +
Sbjct: 2322 CPPGMARRP--DGEGCVDENECRTKPGICENGR-CVNIIGSYRCE--CNEGFQSSSSGTE 2376
Query: 397 LMSNAFRNCVNR--KHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACA 454
+ N C + +C + C +CE LC
Sbjct: 2377 CLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCE-LCPLPGTAQYKKI 2435
Query: 455 CPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSC 510
CP G D RDIDEC + + C NT+GSFRC C GY SC
Sbjct: 2436 CPHGPGYTTDG---RDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSC 2488
Score = 44.4 bits (100), Expect = 0.004
Identities = 41/127 (32%), Positives = 55/127 (43%), Gaps = 16/127 (12%)
Query: 389 YTCR-PQEHLMSNAFRNCVN-RKHVCDGMKDCPRGDDEERCPL-KRKC--------SAEE 437
YTC P E++ N NC++ RK C + ++E + KR C + +
Sbjct: 1714 YTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAGNK 1773
Query: 438 KCEKLCIT--TYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFR 494
CE C T T D C GF DIDEC E +C+ C N +GSFR
Sbjct: 1774 PCEP-CPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECK-EIPGICANGVCINQIGSFR 1831
Query: 495 CGCMTGY 501
C C TG+
Sbjct: 1832 CECPTGF 1838
Score = 41.9 bits (94), Expect = 0.020
Identities = 20/61 (32%), Positives = 27/61 (44%)
Query: 455 CPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTG 514
C GF+ +C+D+DEC C NTVGSF C C G+ + C+
Sbjct: 260 CRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDID 319
Query: 515 E 515
E
Sbjct: 320 E 320
Score = 41.1 bits (92), Expect = 0.035
Identities = 15/38 (39%), Positives = 22/38 (57%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C ++ C+++C G C+CP G L +DGKTC D
Sbjct: 2494 CSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKD 2531
Score = 38.7 bits (86), Expect = 0.19
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NGGC C G C+C G L DG++CAD
Sbjct: 1245 CMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCAD 1282
Score = 38.3 bits (85), Expect = 0.25
Identities = 54/206 (26%), Positives = 72/206 (34%), Gaps = 33/206 (16%)
Query: 315 KCIPERWRCDNERDCAD--GGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCT 372
+C+ R CDN C + G C P + + TC D +G C
Sbjct: 812 ECLVNRLLCDNGL-CRNTPGSYSCTCPPGYVFRTETE--TCEDINECESNPCVNGA--CR 866
Query: 373 NGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCD-GMKDCPRGDDEERCPLKR 431
N NCE C P L S + K C ++D + LK
Sbjct: 867 NNLGSFNCE---------CSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKS 917
Query: 432 KCSAE------EKCEKLCITTYDGHAACACPMGFLLAEDK-YSCRDIDECMYEQDPVCSQ 484
+C A CE+ + T ACP G LA K +C D++EC +
Sbjct: 918 ECCATLGAAWGSPCERCELDT-------ACPRG--LARIKGVTCEDVNECEVFPGVCPNG 968
Query: 485 TCSNTVGSFRCGCMTGYILRPDERSC 510
C N+ GSF C C G L R C
Sbjct: 969 RCVNSKGSFHCECPEGLTLDGTGRVC 994
Score = 35.5 bits (78), Expect = 1.7
Identities = 15/38 (39%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C +N C+ C+ G C CPIG L +D K C D
Sbjct: 2256 CAQNPLLCALRCMNTFGSYECTCPIGYALREDQKMCKD 2293
Score = 35.1 bits (77), Expect = 2.3
Identities = 20/56 (35%), Positives = 27/56 (48%), Gaps = 5/56 (8%)
Query: 1312 IQSERVLENACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKST-TDQTPKKCKSHP 1366
I + L N DNG LC +P Y+C CP G F T T + +C+S+P
Sbjct: 808 IDIDECLVNRLLCDNG----LCRNTPGSYSCTCPPGYVFRTETETCEDINECESNP 859
Score = 33.1 bits (72), Expect = 9.3
Identities = 17/43 (39%), Positives = 20/43 (46%), Gaps = 2/43 (4%)
Query: 1029 LCLLKPGGRSCACPIGIKLNKDGKTCADGPIN--YLIFAHRVD 1069
LC+ PG C CP +LN G C D + YL F R D
Sbjct: 1545 LCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGD 1587
Score = 33.1 bits (72), Expect = 9.3
Identities = 17/61 (27%), Positives = 26/61 (42%), Gaps = 3/61 (4%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTGMPFE---KSTTDQTPKKCKSHPEEFLIFATRGSI 1378
C C+++C + Y C+CP G + K+ D + K H +FL T G
Sbjct: 2494 CSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGF 2553
Query: 1379 T 1379
T
Sbjct: 2554 T 2554
Score = 33.1 bits (72), Expect = 9.3
Identities = 16/47 (34%), Positives = 22/47 (46%), Gaps = 1/47 (2%)
Query: 1319 ENACGTDNGGCSHLCLRSPLGYTCACPTGMPFEK-STTDQTPKKCKS 1364
EN C N S C + Y CACP+G F++ S+ +C S
Sbjct: 2654 ENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSS 2700
>AB209735-1|BAD92972.1| 1976|Homo sapiens fibrillin 2 (congenital
contractural arachnodactyly) variant protein.
Length = 1976
Score = 72.1 bits (169), Expect = 2e-11
Identities = 81/301 (26%), Positives = 121/301 (40%), Gaps = 48/301 (15%)
Query: 258 VELMRCAEIDFECKNTKCVPK--DFQC------DGDNDCGDWTDEDSCPMVPGSCNA--- 306
V++ C+ D C+N KCV +QC D TD D C ++ G C+
Sbjct: 263 VDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCT 322
Query: 307 ---GEFKCN---------DGKCIPERWRCDNERDCADGGD------ELNCKPNSIRNCSL 348
G ++C+ DG+ + C+N D DGG E C S+
Sbjct: 323 NSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASM 382
Query: 349 DEYTCAD-RRCVLKTWLC-DGVRDCTNGEDEMNCEV--SCEEDQYTCRPQEHLMSNAFRN 404
D TC D C L + +C G + T G +C++ S ++ C + A N
Sbjct: 383 DMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGA-HN 441
Query: 405 C---VNRKHVCDGMK-DCPRG--DDEERCPLKRKCS-AEEKC--EKLCITTYDGHAACAC 455
C + ++ K C G + +C +CS +C C+ T G CAC
Sbjct: 442 CDMHASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNT-PGSYRCAC 500
Query: 456 PMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGYILRPDERSCKPTG 514
GF D ++C D+DEC E +C C N G++RC C G+ D RSC+
Sbjct: 501 SEGF--TGDGFTCSDVDECA-ENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDID 557
Query: 515 E 515
E
Sbjct: 558 E 558
Score = 70.1 bits (164), Expect = 7e-11
Identities = 79/275 (28%), Positives = 102/275 (37%), Gaps = 42/275 (15%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
CA+ID EC+N + CDG C + E C G + + K CI
Sbjct: 345 CADID-ECENNPDI-----CDG-GQCTNIPGEYRCLCYDGFMASMDMKT----CIDVN-E 392
Query: 323 CD-NERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCE 381
CD N C G E N K + I +C L Y+ T C V +C G +
Sbjct: 393 CDLNSNICMFGECE-NTKGSFICHCQLG-YSVKKG-----TTGCTDVDECEIGAHNCDMH 445
Query: 382 VSCEE--DQYTCRPQEHLMSNAFR-----NCVNRKHVCDGMKDCPRGDDEERCPLKR--- 431
SC + C +E + N + C N H C C RC
Sbjct: 446 ASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFT 505
Query: 432 ----KCSAEEKCEK---LC----ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP 480
CS ++C + LC G C C MGF A D SC+DIDEC ++
Sbjct: 506 GDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNIC 565
Query: 481 VCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
V TC+N G F C C GY L +C E
Sbjct: 566 VFG-TCNNLPGMFHCICDDGYELDRTGGNCTDIDE 599
Score = 68.9 bits (161), Expect = 2e-10
Identities = 56/217 (25%), Positives = 85/217 (39%), Gaps = 25/217 (11%)
Query: 303 SCNAGEFKCNDGKCIPERWRCDNERD-----CAD--GGDELNCKPNSIRNCSLDEYTCAD 355
SC G DGK + C ++ C + GG C P ++ + C D
Sbjct: 1580 SCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHT----ACID 1635
Query: 356 RR-CVLKTWLCDGVRDCTNGEDEMNCEV----SCEEDQYTCRPQEHLMSNAFRNCVNR-K 409
C + LC C N +CE S + C + N C + +
Sbjct: 1636 NNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGN--HRCQHGCQ 1693
Query: 410 HVCDGMK-DCPRGDDEE----RCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAED 464
++ G + CP+G + +C + +CS C G CACP GF +
Sbjct: 1694 NILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQF 1753
Query: 465 KYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGY 501
+C D++EC ++P C+ CSNT G + CGC GY
Sbjct: 1754 SSACHDVNECSSSKNP-CNYGCSNTEGGYLCGCPPGY 1789
Score = 67.3 bits (157), Expect = 5e-10
Identities = 73/260 (28%), Positives = 98/260 (37%), Gaps = 34/260 (13%)
Query: 278 KDFQCDGDNDCGDWTDEDSCPMVPGSCN--AGEFKCNDGKCIPERWRCDNERDCADGGDE 335
K C N+C DED + GSC G F+C C P DN R C D
Sbjct: 1114 KSENCIDINEC----DEDPNICLFGSCTNTPGGFQC---LCPPGFVLSDNGRRCFDTRQS 1166
Query: 336 LNCKPNSIRNCSLDE-YTCADRRCVLKTWLCDGVRD----CTNGEDEMNCEVSCEEDQYT 390
CS+ + + +C +G D C +DE+ + C T
Sbjct: 1167 FCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPK-DDEVAFQDLCPYGHGT 1225
Query: 391 CRPQEHLMSNAFRNCVNRKHVC--------DGMK--DCPRGDDEE----RCPLKRKCSAE 436
P H C+ +C DG +CP G + + RC +CS
Sbjct: 1226 V-PSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIG 1284
Query: 437 EKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV-CSQTCSNTVGSFRC 495
C T G C C GF +C DI+EC Q+P+ C+ C NT GS+ C
Sbjct: 1285 NPCGNGTCTNVIGSFECNCNEGFEPGP-MMNCEDINECA--QNPLLCAFRCMNTFGSYEC 1341
Query: 496 GCMTGYILRPDERSCKPTGE 515
C GY LR D++ CK E
Sbjct: 1342 TCPIGYALREDQKMCKDLDE 1361
Score = 66.9 bits (156), Expect = 6e-10
Identities = 64/255 (25%), Positives = 95/255 (37%), Gaps = 22/255 (8%)
Query: 269 ECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCI--PERWRCDNE 326
+C+NT F+C ++ +E +C + C C G C+ P + C+
Sbjct: 152 KCRNTI---GSFKCRCNSGFALDMEERNCTDID-ECRISPDLCGSGICVNTPGSFECECF 207
Query: 327 RDCADGGDEL-NCKPNSIRNCSLDEYTCADRRCVLK--TWLCDGVRDCTNGEDEMNCEVS 383
G + NC I C + C CV ++ CD C G +
Sbjct: 208 EGYESGFMMMKNCM--DIDECERNPLLCRGGTCVNTEGSFQCD----CPLGHELSPSRED 261
Query: 384 CEEDQYTCRPQEHLMSNAFRNCVNR--KHVCDGMKDCPRGDDEERCPLKRKCSAEEK-CE 440
C D C ++L N CVN + C D + C +C C+
Sbjct: 262 CV-DINECSLSDNLCRNG--KCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCD 318
Query: 441 KLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTG 500
C T +G C+C G+ L D SC DIDEC D C+N G +RC C G
Sbjct: 319 TQC-TNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDG 377
Query: 501 YILRPDERSCKPTGE 515
++ D ++C E
Sbjct: 378 FMASMDMKTCIDVNE 392
Score = 65.7 bits (153), Expect = 1e-09
Identities = 30/76 (39%), Positives = 40/76 (52%), Gaps = 2/76 (2%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
CI T G C C +G+ SC D+DEC P C+ C NT GS++C C GY+
Sbjct: 1529 CINTM-GSFRCFCKVGYTTDISGTSCIDLDECSQSPKP-CNYICKNTEGSYQCSCPRGYV 1586
Query: 503 LRPDERSCKPTGESPT 518
L+ D ++CK E T
Sbjct: 1587 LQEDGKTCKDLDECQT 1602
Score = 64.9 bits (151), Expect = 2e-09
Identities = 29/71 (40%), Positives = 41/71 (57%), Gaps = 3/71 (4%)
Query: 432 KCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTV 490
+CS K C +C T +G C+CP G++L ED +C+D+DEC +Q C C NT+
Sbjct: 1558 ECSQSPKPCNYICKNT-EGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHN-CQFLCVNTL 1615
Query: 491 GSFRCGCMTGY 501
G F C C G+
Sbjct: 1616 GGFTCKCPPGF 1626
Score = 62.5 bits (145), Expect = 1e-08
Identities = 53/223 (23%), Positives = 81/223 (36%), Gaps = 25/223 (11%)
Query: 304 CNAGEFKCNDGKCIPER--WRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCV-- 359
C C G C+ ++CD +C I CSL + C + +CV
Sbjct: 226 CERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCV--DINECSLSDNLCRNGKCVNM 283
Query: 360 LKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCP 419
+ T+ C C G C + E ++ N C + +G +C
Sbjct: 284 IGTYQCS----CNPGYQATPDRQGCTDID------ECMIMNG--GCDTQCTNSEGSYECS 331
Query: 420 RGDDEERCPLKRKCSAEEKCEK---LC----ITTYDGHAACACPMGFLLAEDKYSCRDID 472
+ P R C+ ++CE +C T G C C GF+ + D +C D++
Sbjct: 332 CSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVN 391
Query: 473 ECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
EC + C NT GSF C C GY ++ C E
Sbjct: 392 ECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDE 434
Score = 62.1 bits (144), Expect = 2e-08
Identities = 30/82 (36%), Positives = 40/82 (48%), Gaps = 3/82 (3%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ--TCSNTVGSFRCG 496
C C+ T+ G C CP+G+ L ED+ C+D+DEC S+ C N +G+F C
Sbjct: 1328 CAFRCMNTF-GSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCI 1386
Query: 497 CMTGYILRPDERSCKPTGESPT 518
C G RPD C E T
Sbjct: 1387 CPPGMARRPDGEGCVDENECRT 1408
Score = 61.7 bits (143), Expect = 2e-08
Identities = 78/280 (27%), Positives = 112/280 (40%), Gaps = 48/280 (17%)
Query: 263 CAEIDFECKNTKC--VPKDFQCDGD------NDCGDWTDEDSCPM----VPGSCN--AGE 308
CAE C+N +C VP ++C+ + +D D D C V G+CN G
Sbjct: 517 CAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGM 576
Query: 309 FKC--NDGKCIPERW-RCDNERDCAD-------------GGDELNCKPNSIRNCSLDEYT 352
F C +DG + C + +CAD G E NC P+ N +
Sbjct: 577 FHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPT--GVG 634
Query: 353 CADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ-EHLMSNAFRNCVNRKHV 411
C D R V +L G R +G N E+ + +C N C
Sbjct: 635 CVDNR-VGNCYLKFGPRG--DGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNST 691
Query: 412 CDGMKDCPRGDDEERCPLKRKCSAEEKCEKL--------CITTYDGHAACACPMGFLLAE 463
+ CP G+ P+ ++C++L CI T+ G C CP G+ L+E
Sbjct: 692 -EYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTF-GSFQCECPQGYYLSE 749
Query: 464 DKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGYI 502
D C DIDEC + VC TC NT+G++ C C Y+
Sbjct: 750 DTRICEDIDEC-FAHPGVCGPGTCYNTLGNYTCICPPEYM 788
Score = 60.1 bits (139), Expect = 7e-08
Identities = 58/231 (25%), Positives = 86/231 (37%), Gaps = 22/231 (9%)
Query: 297 CPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADR 356
CP PG G ++ K +P C N + C + C + +C D
Sbjct: 1501 CPHGPGYTTDGR-DIDECKVMPNL--CTNGQ-CINTMGSFRCFCKVGYTTDISGTSCIDL 1556
Query: 357 -RCVLKTWLCDGVRDCTNGEDEMNCEVS--CEEDQYTCRPQEHLMS---NAFRNCVNRKH 410
C C+ + T G + +C +ED TC+ + + N CVN
Sbjct: 1557 DECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVN--- 1613
Query: 411 VCDGMK-DCPRGDDEER--CPLKRKCSAEEK---CEKLCITTYDGHAACACPMGFLLAED 464
G CP G + C +C ++ + +C T G +C C GF L
Sbjct: 1614 TLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNT-PGSFSCECQRGFSLDAT 1672
Query: 465 KYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
+C D+DEC + + C C N +G +RCGC GYI C E
Sbjct: 1673 GLNCEDVDEC--DGNHRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENE 1721
Score = 59.3 bits (137), Expect = 1e-07
Identities = 46/166 (27%), Positives = 60/166 (36%), Gaps = 12/166 (7%)
Query: 364 LCDGVRDCTNGEDEMNCEVSCE---------EDQYTCRPQEHLMSNAFRNCVNRKHVCDG 414
LC DC N CE + D+ C ++ S+ + + C
Sbjct: 924 LCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCIC 983
Query: 415 MKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
D+ C +C C T G C C GF L + C DIDEC
Sbjct: 984 HNGFKASQDQTMCMDVDECERHPCGNGTCKNTV-GSYNCLCYPGFELTHNN-DCLDIDEC 1041
Query: 475 MYEQDPVCSQ-TCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTL 519
VC C N +GSF+C C GY L PD ++C T E L
Sbjct: 1042 SSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVAL 1087
Score = 56.0 bits (129), Expect = 1e-06
Identities = 76/353 (21%), Positives = 113/353 (32%), Gaps = 22/353 (6%)
Query: 163 NRTICHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTV 222
+R C + C+ + CD C + C + L+P + +I + NP +
Sbjct: 300 DRQGCTDIDECMIMNGGCD--TQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDI 357
Query: 223 LIALTKPTVVIRYESFCAKKALDNAANPRSTWNQPVELMRCAEIDFECKNTKCVPKDFQC 282
+ Y C + + +L + EC+NTK F C
Sbjct: 358 CDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTK---GSFIC 414
Query: 283 DGDNDCGDWTDEDSCPMVPGSCNAGEFKCN-DGKC--IPERWRCDNERDCADGGDELNCK 339
C V C G C+ C IP ++C C +G K
Sbjct: 415 HCQLGYSVKKGTTGCTDVD-ECEIGAHNCDMHASCLNIPGSFKCS----CREGWIGNGIK 469
Query: 340 PNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMS 399
+ CS + C+ + T G C E +C D C +L
Sbjct: 470 CIDLDECSNGTHQCSINAQCVNT---PGSYRCACSEGFTGDGFTCS-DVDECAENINLCE 525
Query: 400 NAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGF 459
N V + C+ D C +CS + C G C C G+
Sbjct: 526 NGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGY 585
Query: 460 LLAEDKYSCRDIDECMYEQDPV-C-SQTCSNTVGSFRCGCMTGYILRPDERSC 510
L +C DIDEC DP+ C + C NT G + C C + L P C
Sbjct: 586 ELDRTGGNCTDIDEC---ADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGC 635
Score = 55.2 bits (127), Expect = 2e-06
Identities = 72/275 (26%), Positives = 107/275 (38%), Gaps = 35/275 (12%)
Query: 260 LMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND-GKCIP 318
L+ C +ID EC N D C + DC + C G + C D +C+
Sbjct: 909 LLVCEDID-ECSNG-----DNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLE 962
Query: 319 ERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDE 377
C + C D C ++ S D+ C D C + C G C N
Sbjct: 963 IPNVCSHGL-CVDLQGSYQCICHNGFKASQDQTMCMDVDEC--ERHPC-GNGTCKNTVGS 1018
Query: 378 MNC------EVSCEEDQYTCRPQEHLMSNAFRN--CVNR----KHVC-DGMKDCPRGDDE 424
NC E++ D RN C N K +C +G + P G
Sbjct: 1019 YNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDG--- 1075
Query: 425 ERCPLKRKCSA-EEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VC 482
+ C +C A C +G C CP G+ + + +C DI+EC ++DP +C
Sbjct: 1076 KNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSE--NCIDINEC--DEDPNIC 1131
Query: 483 S-QTCSNTVGSFRCGCMTGYILRPDERSCKPTGES 516
+C+NT G F+C C G++L + R C T +S
Sbjct: 1132 LFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQS 1166
Score = 54.4 bits (125), Expect = 4e-06
Identities = 75/295 (25%), Positives = 110/295 (37%), Gaps = 43/295 (14%)
Query: 258 VELMRCAEIDFECK-NTKCV--PKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDG 314
++L C+ +C N +CV P ++C G D +C V C C +G
Sbjct: 471 IDLDECSNGTHQCSINAQCVNTPGSYRCACSE--GFTGDGFTCSDVD-ECAENINLCENG 527
Query: 315 KC--IPERWRCDNERDCADGGDELNCKPNSIRNCSLDEY----TCADRRCVLKTWLCDGV 368
+C +P +RC+ E D +C+ I CS TC + + DG
Sbjct: 528 QCLNVPGAYRCECEMGFTPASDSRSCQ--DIDECSFQNICVFGTCNNLPGMFHCICDDGY 585
Query: 369 R-DCTNGE----DEMNCEVSCEED-------QYTCR-PQEHLMSNAFRNCVNRKHVCDGM 415
D T G DE ++C +Y C P + ++ CV+ + +
Sbjct: 586 ELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYL 645
Query: 416 KDCPRGDDEERCP------LKRK---CSAEEKCEKLC-----ITTYDGHAACACPMGFLL 461
K PRGD C + R CS + C + + + + C GF
Sbjct: 646 KFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRP 705
Query: 462 AEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
DIDEC E +C C NT GSF+C C GY L D R C+ E
Sbjct: 706 NPITIILEDIDECQ-ELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDE 759
Score = 51.2 bits (117), Expect = 3e-05
Identities = 23/84 (27%), Positives = 38/84 (45%), Gaps = 2/84 (2%)
Query: 432 KCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVG 491
+C +C+ C G+ C CP G++ C D +EC + S +C NT+G
Sbjct: 1681 ECDGNHRCQHGCQNILGGYR-CGCPQGYIQHYQWNQCVDENECS-NPNACGSASCYNTLG 1738
Query: 492 SFRCGCMTGYILRPDERSCKPTGE 515
S++C C +G+ +C E
Sbjct: 1739 SYKCACPSGFSFDQFSSACHDVNE 1762
Score = 50.4 bits (115), Expect = 6e-05
Identities = 26/67 (38%), Positives = 34/67 (50%), Gaps = 4/67 (5%)
Query: 442 LCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQT--CSNTVGSFRCGCMT 499
+CI G C CP GF + C DIDEC D +C + C N+ GS+RC C
Sbjct: 887 VCINQI-GSFRCECPTGFSYNDLLLVCEDIDECS-NGDNLCQRNADCINSPGSYRCECAA 944
Query: 500 GYILRPD 506
G+ L P+
Sbjct: 945 GFKLSPN 951
Score = 46.8 bits (106), Expect = 7e-04
Identities = 66/262 (25%), Positives = 92/262 (35%), Gaps = 23/262 (8%)
Query: 256 QPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCND-G 314
+P +M C +I+ EC + F+C N G + E +CP + + + C D
Sbjct: 1308 EPGPMMNCEDIN-ECAQNPLLCA-FRCM--NTFGSY--ECTCP-IGYALREDQKMCKDLD 1360
Query: 315 KCIPERWRCDNE-RDCAD--GGDELNCKPNSIRNCSLDEYTCADRR-CVLKTWLCDGVRD 370
+C C++ C + G C P R D C D C K +C+ R
Sbjct: 1361 ECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRP--DGEGCVDENECRTKPGICENGR- 1417
Query: 371 CTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNR--KHVCDGMKDCPRGDDEERCP 428
C N CE C E + + N C + +C + C
Sbjct: 1418 CVNIIGSYRCE--CNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECC 1475
Query: 429 LKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSN 488
+CE LC CP G D RDIDEC + + C N
Sbjct: 1476 CDGGRGWGHQCE-LCPLPGTAQYKKICPHGPGYTTDG---RDIDECKVMPNLCTNGQCIN 1531
Query: 489 TVGSFRCGCMTGYILRPDERSC 510
T+GSFRC C GY SC
Sbjct: 1532 TMGSFRCFCKVGYTTDISGTSC 1553
Score = 43.6 bits (98), Expect = 0.007
Identities = 41/127 (32%), Positives = 54/127 (42%), Gaps = 16/127 (12%)
Query: 389 YTCR-PQEHLMSNAFRNCVN-RKHVCDGMKDCPRGDDEERCPL-KRKCSA--------EE 437
YTC P E++ N NC++ RK C + ++E + KR C +
Sbjct: 779 YTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNK 838
Query: 438 KCEKLCIT--TYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFR 494
CE C T T D C GF DIDEC E +C+ C N +GSFR
Sbjct: 839 PCEP-CPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECK-EIPGICANGVCINQIGSFR 896
Query: 495 CGCMTGY 501
C C TG+
Sbjct: 897 CECPTGF 903
Score = 41.1 bits (92), Expect = 0.035
Identities = 15/38 (39%), Positives = 22/38 (57%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C ++ C+++C G C+CP G L +DGKTC D
Sbjct: 1559 CSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKD 1596
Score = 38.7 bits (86), Expect = 0.19
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NGGC C G C+C G L DG++CAD
Sbjct: 310 CMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCAD 347
Score = 37.1 bits (82), Expect = 0.57
Identities = 22/58 (37%), Positives = 27/58 (46%), Gaps = 3/58 (5%)
Query: 454 ACPMGFLLAEDK-YSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSC 510
ACP G LA K +C D++EC + C N+ GSF C C G L R C
Sbjct: 4 ACPRG--LARIKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVC 59
Score = 36.3 bits (80), Expect = 1.00
Identities = 15/38 (39%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C +N C+ C+ G C CPIG L +D K C D
Sbjct: 1321 CAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKD 1358
Score = 33.1 bits (72), Expect = 9.3
Identities = 17/43 (39%), Positives = 20/43 (46%), Gaps = 2/43 (4%)
Query: 1029 LCLLKPGGRSCACPIGIKLNKDGKTCADGPIN--YLIFAHRVD 1069
LC+ PG C CP +LN G C D + YL F R D
Sbjct: 610 LCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGD 652
Score = 33.1 bits (72), Expect = 9.3
Identities = 17/61 (27%), Positives = 26/61 (42%), Gaps = 3/61 (4%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTGMPFE---KSTTDQTPKKCKSHPEEFLIFATRGSI 1378
C C+++C + Y C+CP G + K+ D + K H +FL T G
Sbjct: 1559 CSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGF 1618
Query: 1379 T 1379
T
Sbjct: 1619 T 1619
Score = 33.1 bits (72), Expect = 9.3
Identities = 16/47 (34%), Positives = 22/47 (46%), Gaps = 1/47 (2%)
Query: 1319 ENACGTDNGGCSHLCLRSPLGYTCACPTGMPFEK-STTDQTPKKCKS 1364
EN C N S C + Y CACP+G F++ S+ +C S
Sbjct: 1719 ENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSS 1765
>AC010895-1|AAY14669.1| 320|Homo sapiens unknown protein.
Length = 320
Score = 71.7 bits (168), Expect = 2e-11
Identities = 38/103 (36%), Positives = 52/103 (50%), Gaps = 5/103 (4%)
Query: 418 CPRGDDE--ERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECM 475
CP G + E+C +C+ C + C+ T G C C GF LA + Y+C DI+EC
Sbjct: 28 CPPGYQKRGEQCVDIDECTIPPYCHQRCVNT-PGSFYCQCSPGFQLAANNYTCVDINEC- 85
Query: 476 YEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESPT 518
+ C+Q C N +GSF C C GY L D +C+ E T
Sbjct: 86 -DASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT 127
Score = 49.2 bits (112), Expect = 1e-04
Identities = 41/159 (25%), Positives = 62/159 (38%), Gaps = 15/159 (9%)
Query: 371 CTNGEDEMNCEVS----CEEDQYTCRP-QEHLMSN-AFRNCVN--RKHVCDGMKDCPRGD 422
C N C+ S + YTC E SN + C N +C +
Sbjct: 55 CVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSS 114
Query: 423 DEERCPLKRKC-SAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV 481
D C +C ++ C+ C+ G +C CP G+ + + +C+DI+EC +
Sbjct: 115 DRLNCEDIDECRTSSYLCQYQCVNE-PGKFSCMCPQGYQVVRSR-TCQDINECETTNECR 172
Query: 482 CSQTCSNTVGSFRC----GCMTGYILRPDERSCKPTGES 516
+ C N G FRC C YIL P+ R P +
Sbjct: 173 EDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNA 211
Score = 34.3 bits (75), Expect = 4.0
Identities = 14/46 (30%), Positives = 23/46 (50%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPE 1367
C T + C + C+ P ++C CP G +S T Q +C++ E
Sbjct: 125 CRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNE 170
>AK056571-1|BAB71219.1| 955|Homo sapiens protein ( Homo sapiens
cDNA FLJ32009 fis, clone NT2RP7009498, weakly similar to
FIBULIN-1, ISOFORM A PRECURSOR. ).
Length = 955
Score = 71.3 bits (167), Expect = 3e-11
Identities = 33/90 (36%), Positives = 47/90 (52%), Gaps = 5/90 (5%)
Query: 426 RCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQT 485
RC +C CE C+ T +G C C G L+ D++SC+D DEC+ C Q
Sbjct: 139 RCTDIDEC-VTSSCEGHCVNT-EGGFVCECGPGMQLSADRHSCQDTDECL---GTPCQQR 193
Query: 486 CSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C N++GS++C C TG+ L + SC E
Sbjct: 194 CKNSIGSYKCSCRTGFHLHGNRHSCVDVNE 223
Score = 70.1 bits (164), Expect = 7e-11
Identities = 63/207 (30%), Positives = 83/207 (40%), Gaps = 21/207 (10%)
Query: 309 FKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGV 368
F C G CI N C DG C P + C EY C D C C V
Sbjct: 73 FGCGSGICI-----APNVCSCQDGEQGATC-PETHGPCG--EYGC-DLTC--NHGGCQEV 121
Query: 369 -RDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRK--HVCDGMKDCPRGDDEE 425
R C G V E + S+ +CVN + VC+ D
Sbjct: 122 ARVCPVGFSMTEAAVGIRCTDI----DECVTSSCEGHCVNTEGGFVCECGPGMQLSADRH 177
Query: 426 RCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQ 484
C +C C++ C + G C+C GF L +++SC D++EC + VC
Sbjct: 178 SCQDTDECLGTP-CQQRCKNSI-GSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHH 235
Query: 485 TCSNTVGSFRCGCMTGYILRPDERSCK 511
+C NTVGSF C C G+ LR D SC+
Sbjct: 236 SCHNTVGSFLCTCRPGFRLRADRVSCE 262
>AF093119-1|AAC62108.1| 439|Homo sapiens UPH1 protein.
Length = 439
Score = 70.9 bits (166), Expect = 4e-11
Identities = 63/237 (26%), Positives = 89/237 (37%), Gaps = 22/237 (9%)
Query: 283 DGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK----CIPERWRCDNERDCADGGDE--- 335
DG + D + C +P +C GE KC + C+P N+ +G
Sbjct: 41 DGYTQTANCRDVNECLTIPEACK-GEMKCINHYGGYLCLPRSAAVINDLH-GEGPPPPVP 98
Query: 336 -LNCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRP 393
+N +P D+ +C D C C +DC N C +C + P
Sbjct: 99 PVNTQPLPTGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQC--TCPDGYRKIGP 156
Query: 394 Q-EHLMSNAFRNCVNRKHVCDGMKDCP------RGDDEERCPLKRKCSAEEKCEKLCITT 446
+ + +R C +R G C G + C +C CE+ C +
Sbjct: 157 ECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNS 216
Query: 447 YDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYIL 503
Y G C C G+ L D +SC DIDEC Y +C C N G F C C GY L
Sbjct: 217 Y-GTFLCRCHQGYELHRDGFSCSDIDECSY-SSYLCQYRCVNEPGRFSCHCPQGYQL 271
Score = 58.0 bits (134), Expect = 3e-07
Identities = 52/176 (29%), Positives = 67/176 (38%), Gaps = 16/176 (9%)
Query: 349 DEYT-CADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQ--YTCRPQEHLMSNAFRNC 405
D YT C D +T C V +C + E+ C Y C P+ + N
Sbjct: 34 DSYTECTDG--YTQTANCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGE 91
Query: 406 VNRKHVCD-GMKDCPRG---DDEERCPLKRKCS-AEEKCE-KLCITTYDGHAACACPMGF 459
V + P G DD++ C +C+ A C G C CP G+
Sbjct: 92 GPPPPVPPVNTQPLPTGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGY 151
Query: 460 LLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
+ C DIDEC Y C C N GSFRC C G+ L P+ RSC E
Sbjct: 152 RKIGPE--CVDIDECRYRY---CQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNE 202
Score = 57.2 bits (132), Expect = 5e-07
Identities = 28/77 (36%), Positives = 36/77 (46%), Gaps = 3/77 (3%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCM 498
C+ C+ G C C GF L + SC D++EC + C Q C N+ G+F C C
Sbjct: 169 CQHRCVNL-PGSFRCQCEPGFQLGPNNRSCVDVNEC--DMGAPCEQRCFNSYGTFLCRCH 225
Query: 499 TGYILRPDERSCKPTGE 515
GY L D SC E
Sbjct: 226 QGYELHRDGFSCSDIDE 242
Score = 46.8 bits (106), Expect = 7e-04
Identities = 61/249 (24%), Positives = 95/249 (38%), Gaps = 31/249 (12%)
Query: 272 NTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCAD 331
NT+ +P ++ D + C D D C C + C++ +P ++C C D
Sbjct: 101 NTQPLPTGYEPDDQDSC---VDVDECAQALHDCRPSQ-DCHN---LPGSYQCT----CPD 149
Query: 332 GGDELNCKPNSIRNCSLDEYTCADRRCVLK--TWLCDGVRDCTNGEDEMNCEVSCEEDQY 389
G ++ + I C Y RCV ++ C G + +C E D
Sbjct: 150 GYRKIGPECVDIDEC---RYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMG 206
Query: 390 TCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCS-AEEKCEKLCITTYD 448
P E N++ + R H + D C +CS + C+ C+
Sbjct: 207 A--PCEQRCFNSYGTFLCRCH-----QGYELHRDGFSCSDIDECSYSSYLCQYRCVNE-P 258
Query: 449 GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC-SQTCSNTVGSFRC----GCMTGYIL 503
G +C CP G+ L + C+DIDEC +QTC N G +RC C+ YI
Sbjct: 259 GRFSCHCPQGYQLLATRL-CQDIDECESGAHQWSEAQTCVNFHGGYRCVDTNRCVEPYIQ 317
Query: 504 RPDERSCKP 512
+ R P
Sbjct: 318 VSENRCLCP 326
>BC077719-1|AAH77719.1| 219|Homo sapiens VWCE protein protein.
Length = 219
Score = 70.5 bits (165), Expect = 5e-11
Identities = 32/85 (37%), Positives = 46/85 (54%), Gaps = 5/85 (5%)
Query: 426 RCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQT 485
RC +C CE C+ T +G C C G L+ D++SC+D DEC+ C Q
Sbjct: 139 RCTDIDEC-VTSSCEGHCVNT-EGGFVCECGPGMQLSADRHSCQDTDECL---GTPCQQR 193
Query: 486 CSNTVGSFRCGCMTGYILRPDERSC 510
C N++GS++C C TG+ L + SC
Sbjct: 194 CKNSIGSYKCSCRTGFHLHGNRHSC 218
Score = 58.0 bits (134), Expect = 3e-07
Identities = 34/100 (34%), Positives = 40/100 (40%), Gaps = 5/100 (5%)
Query: 418 CPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYS--CRDIDECM 475
C G+ CP E C+ C A CP+GF + E C DIDEC+
Sbjct: 88 CQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECV 147
Query: 476 YEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C C NT G F C C G L D SC+ T E
Sbjct: 148 TSS---CEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDE 184
>BC052564-1|AAH52564.1| 219|Homo sapiens VWCE protein protein.
Length = 219
Score = 70.5 bits (165), Expect = 5e-11
Identities = 32/85 (37%), Positives = 46/85 (54%), Gaps = 5/85 (5%)
Query: 426 RCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQT 485
RC +C CE C+ T +G C C G L+ D++SC+D DEC+ C Q
Sbjct: 139 RCTDIDEC-VTSSCEGHCVNT-EGGFVCECGPGMQLSADRHSCQDTDECL---GTPCQQR 193
Query: 486 CSNTVGSFRCGCMTGYILRPDERSC 510
C N++GS++C C TG+ L + SC
Sbjct: 194 CKNSIGSYKCSCRTGFHLHGNRHSC 218
Score = 58.0 bits (134), Expect = 3e-07
Identities = 34/100 (34%), Positives = 40/100 (40%), Gaps = 5/100 (5%)
Query: 418 CPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYS--CRDIDECM 475
C G+ CP E C+ C A CP+GF + E C DIDEC+
Sbjct: 88 CQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECV 147
Query: 476 YEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C C NT G F C C G L D SC+ T E
Sbjct: 148 TSS---CEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDE 184
>BC042143-1|AAH42143.1| 237|Homo sapiens VWCE protein protein.
Length = 237
Score = 70.5 bits (165), Expect = 5e-11
Identities = 32/85 (37%), Positives = 46/85 (54%), Gaps = 5/85 (5%)
Query: 426 RCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQT 485
RC +C CE C+ T +G C C G L+ D++SC+D DEC+ C Q
Sbjct: 157 RCTDIDEC-VTSSCEGHCVNT-EGGFVCECGPGMQLSADRHSCQDTDECL---GTPCQQR 211
Query: 486 CSNTVGSFRCGCMTGYILRPDERSC 510
C N++GS++C C TG+ L + SC
Sbjct: 212 CKNSIGSYKCSCRTGFHLHGNRHSC 236
Score = 58.0 bits (134), Expect = 3e-07
Identities = 34/100 (34%), Positives = 40/100 (40%), Gaps = 5/100 (5%)
Query: 418 CPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYS--CRDIDECM 475
C G+ CP E C+ C A CP+GF + E C DIDEC+
Sbjct: 106 CQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECV 165
Query: 476 YEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C C NT G F C C G L D SC+ T E
Sbjct: 166 TSS---CEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDE 202
>Z37976-1|CAA86030.1| 1821|Homo sapiens LTBP-2 precursor protein.
Length = 1821
Score = 69.7 bits (163), Expect = 9e-11
Identities = 69/252 (27%), Positives = 95/252 (37%), Gaps = 25/252 (9%)
Query: 270 CKNTKCVPKD--FQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPER--WRCDN 325
C + KC + F+C + +DE C V C A C G C+ + C
Sbjct: 1020 CAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVD-EC-ASRASCPTGLCLNTEGSFACSA 1077
Query: 326 ERDCADGG--DELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVS 383
C +G +E + C+ C C T +DC G S
Sbjct: 1078 ---CENGYWVNEDGTACEDLDECAFPG-VCPSGVCT-NTAGSFSCKDCDGGYRPSPLGDS 1132
Query: 384 CEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEER---CPLKRKCSAEEKCE 440
CE+ PQ + +N V + C CP+G C +C EE C
Sbjct: 1133 CEDVDECEDPQSSCLGGECKNTVG-SYQCL----CPQGFQLANGTVCEDVNECMGEEHCA 1187
Query: 441 KL--CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCM 498
C+ ++ G C C GF+ AE SC+D+DEC DP C NT GSF C C
Sbjct: 1188 PHGECLNSH-GSFFCLCAPGFVSAEGGTSCQDVDECA-TTDPCVGGHCVNTEGSFNCLCE 1245
Query: 499 TGYILRPDERSC 510
TG+ P+ C
Sbjct: 1246 TGFQPSPESGEC 1257
Score = 61.7 bits (143), Expect = 2e-08
Identities = 70/262 (26%), Positives = 97/262 (37%), Gaps = 30/262 (11%)
Query: 270 CKNTKCV--PKDFQC----DG-DNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C + +CV P + C +G G D + C + PG C G KC + + +R
Sbjct: 980 CPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNEC-LTPGVCAHG--KCTN---LEGSFR 1033
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV 382
C E+ DE C+ + C+ +C C L T C NG
Sbjct: 1034 CSCEQGYEVTSDEKGCQ--DVDECA-SRASCPTGLC-LNTEGSFACSACENGYWVNEDGT 1089
Query: 383 SCEEDQYTCRPQEHLMSNAFRNCVNRKHV--CDG-MKDCPRGD---DEERCPLKRKCSAE 436
+CE D C S N CDG + P GD D + C +
Sbjct: 1090 ACE-DLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLG 1148
Query: 437 EKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCG 496
+C+ G C CP GF LA C D++ECM E+ C N+ GSF C
Sbjct: 1149 GECKNTV-----GSYQCLCPQGFQLANGTV-CEDVNECMGEEHCAPHGECLNSHGSFFCL 1202
Query: 497 CMTGYILRPDERSCKPTGESPT 518
C G++ SC+ E T
Sbjct: 1203 CAPGFVSAEGGTSCQDVDECAT 1224
Score = 59.3 bits (137), Expect = 1e-07
Identities = 65/244 (26%), Positives = 95/244 (38%), Gaps = 30/244 (12%)
Query: 270 CKNTKCVPKD-FQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERD 328
C+N V +D C+ ++C CP + AG F C D CD
Sbjct: 1078 CENGYWVNEDGTACEDLDECAF---PGVCPSGVCTNTAGSFSCKD---------CDGGYR 1125
Query: 329 CADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQ 388
+ GD +C+ + C + +C C K + C G N V CE D
Sbjct: 1126 PSPLGD--SCE--DVDECEDPQSSCLGGEC--KNTVGSYQCLCPQGFQLANGTV-CE-DV 1177
Query: 389 YTCRPQEHLMSNAFRNCVNR--KHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEK-LCIT 445
C +EH + C+N C + C +C+ + C C+
Sbjct: 1178 NECMGEEHCAPHG--ECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVN 1235
Query: 446 TYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC-SQTCSNTVGSFRC--GCMTGYI 502
T +G C C GF + + C DIDEC DPVC + C N+ GS+RC GC G+
Sbjct: 1236 T-EGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFH 1294
Query: 503 LRPD 506
+ P+
Sbjct: 1295 MAPN 1298
Score = 52.0 bits (119), Expect = 2e-05
Identities = 63/243 (25%), Positives = 92/243 (37%), Gaps = 36/243 (14%)
Query: 293 DEDSCPMVPGSCNAGEF---------KCNDGKCIPERWRCDNERDCADGGD--ELNC--K 339
D + C PG C+ G+ +C+ G + + C + +C G + C
Sbjct: 930 DINECEQ-PGVCSGGQCTNTEGSYHCECDQGYIMVRKGHCQDINECRHPGTCPDGRCVNS 988
Query: 340 PNSIRNCSLDE-YTCADRRCV-LKTWLCDGV---RDCTNGEDEMNCEVSCEE------DQ 388
P S + +E Y CV + L GV CTN E C SCE+ D+
Sbjct: 989 PGSYTCLACEEGYRGQSGSCVDVNECLTPGVCAHGKCTNLEGSFRC--SCEQGYEVTSDE 1046
Query: 389 YTCRPQEHLMSNAFRN---CVNRKHVCDGMKDCPRG----DDEERCPLKRKCSAEEKCEK 441
C+ + S A C+N + C G +D C +C+ C
Sbjct: 1047 KGCQDVDECASRASCPTGLCLNTEGSF-ACSACENGYWVNEDGTACEDLDECAFPGVCPS 1105
Query: 442 LCITTYDGHAACA-CPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTG 500
T G +C C G+ + SC D+DEC Q C NTVGS++C C G
Sbjct: 1106 GVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQG 1165
Query: 501 YIL 503
+ L
Sbjct: 1166 FQL 1168
Score = 47.6 bits (108), Expect = 4e-04
Identities = 27/83 (32%), Positives = 37/83 (44%), Gaps = 5/83 (6%)
Query: 432 KCSAEEKCEK-LCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP--VCSQT-CS 487
+C CE C+ +G+ C C GF L +C D++EC P +C C
Sbjct: 1736 ECGILNGCENGRCVRVREGYT-CDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCE 1794
Query: 488 NTVGSFRCGCMTGYILRPDERSC 510
NT GS+RC C GY+ C
Sbjct: 1795 NTEGSYRCHCSPGYVAEAGPPHC 1817
Score = 46.8 bits (106), Expect = 7e-04
Identities = 29/104 (27%), Positives = 40/104 (38%), Gaps = 8/104 (7%)
Query: 414 GMKDCPRGD--DEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDI 471
G P GD D + C C + C+ DG C C GF ++ + C D+
Sbjct: 1292 GFHMAPNGDCIDIDECANDTMCGSHGFCDNT-----DGSFRCLCDQGFEISPSGWDCVDV 1346
Query: 472 DECMYEQDPVCSQTCSNTVGSFRCGCMTGY-ILRPDERSCKPTG 514
+EC + C N GSF C C + E C+P G
Sbjct: 1347 NECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRG 1390
Score = 46.4 bits (105), Expect = 0.001
Identities = 71/272 (26%), Positives = 100/272 (36%), Gaps = 47/272 (17%)
Query: 270 CKNTKCVPKDFQCDGD---NDCGD-WTDEDSCPMVPGSCNAGEFKCNDG--KCI-PERWR 322
C NT CDG + GD D D C SC GE K G +C+ P+ ++
Sbjct: 1108 CTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQ 1167
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLK--TWLCDGVRDCTNGEDEMNC 380
N C D + C +E+ C+ ++ C C G
Sbjct: 1168 LANGTVCED-----------VNECMGEEHCAPHGECLNSHGSFFCL----CAPGFVSAEG 1212
Query: 381 EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCE 440
SC+ D C + + +CVN +G +C + P +C ++CE
Sbjct: 1213 GTSCQ-DVDECATTDPCVGG---HCVNT----EGSFNCLCETGFQPSPESGECVDIDECE 1264
Query: 441 K----LCIT----TYDGHAACA--CPMGFLLAEDKYSCRDIDECMYEQDPVCSQT--CSN 488
+C T G C C GF +A + C DIDEC D +C C N
Sbjct: 1265 DYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNG-DCIDIDECA--NDTMCGSHGFCDN 1321
Query: 489 TVGSFRCGCMTGYILRPDERSCKPTGESPTLL 520
T GSFRC C G+ + P C E +L
Sbjct: 1322 TDGSFRCLCDQGFEISPSGWDCVDVNECELML 1353
Score = 44.8 bits (101), Expect = 0.003
Identities = 23/62 (37%), Positives = 32/62 (51%), Gaps = 4/62 (6%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGY 501
C+ DG+ C C G+ L + C D +EC+ +DP + C N VGS+ C C GY
Sbjct: 861 CVNLPDGYR-CVCSPGYQLHPSQAYCTDDNECL--RDPCQGKGRCINRVGSYSCFCYPGY 917
Query: 502 IL 503
L
Sbjct: 918 TL 919
Score = 44.4 bits (100), Expect = 0.004
Identities = 29/90 (32%), Positives = 36/90 (40%), Gaps = 5/90 (5%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGY 501
C+ T G+ C C GF C D DEC QD C C NT GSF C C
Sbjct: 1502 CLNTVPGYV-CLCNPGFHYDASHKKCEDHDEC---QDLACENGECVNTEGSFHCFCSPPL 1557
Query: 502 ILRPDERSCKPTGESPTLLFSNRIGIRQVW 531
L ++ C + S L + I + W
Sbjct: 1558 TLDLSQQRCMNSTSSTEDLPDHDIHMDICW 1587
Score = 41.1 bits (92), Expect = 0.035
Identities = 28/96 (29%), Positives = 39/96 (40%), Gaps = 7/96 (7%)
Query: 425 ERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ 484
+ C +C C T +G C C G+++ K C+DI+EC + C
Sbjct: 926 QECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVR-KGHCQDINECRH--PGTCPD 982
Query: 485 -TCSNTVGSFRC-GCMTGYILRPDERSCKPTGESPT 518
C N+ GS+ C C GY R SC E T
Sbjct: 983 GRCVNSPGSYTCLACEEGY--RGQSGSCVDVNECLT 1016
Score = 37.9 bits (84), Expect = 0.33
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 4/57 (7%)
Query: 455 CPMGFLLAEDKYSCRDIDECMYEQDPVCSQT-CSNTVGSFRCGCMTGYILRPDERSC 510
CP G+ + C+DI+EC+ +C C NT GS+ C C G +L P C
Sbjct: 608 CPQGYKRLNLTH-CQDINECLTLG--LCKDAECVNTRGSYLCTCRPGLMLDPSRSRC 661
Score = 35.1 bits (77), Expect = 2.3
Identities = 17/46 (36%), Positives = 19/46 (41%), Gaps = 1/46 (2%)
Query: 471 IDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
ID C VC TC N +RC C GY L P + C E
Sbjct: 845 IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNE 890
>Y00318-2|CAA68417.1| 321|Homo sapiens protein ( Human mRNA for
complement control protein factor I. ).
Length = 321
Score = 69.7 bits (163), Expect = 9e-11
Identities = 30/71 (42%), Positives = 40/71 (56%), Gaps = 4/71 (5%)
Query: 268 FECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNER 327
F+C N K + + CDG NDCGD +DE C +C F C G CIP +++C+ E
Sbjct: 209 FQCVNGKYISQMKACDGINDCGDQSDELCCK----ACQGKGFHCKSGVCIPSQYQCNGEV 264
Query: 328 DCADGGDELNC 338
DC G DE+ C
Sbjct: 265 DCITGEDEVGC 275
Score = 56.8 bits (131), Expect = 7e-07
Identities = 27/72 (37%), Positives = 35/72 (48%), Gaps = 5/72 (6%)
Query: 309 FKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGV 368
F+C +GK I + CD DC D DEL CK C + C C+ + C+G
Sbjct: 209 FQCVNGKYISQMKACDGINDCGDQSDELCCKA-----CQGKGFHCKSGVCIPSQYQCNGE 263
Query: 369 RDCTNGEDEMNC 380
DC GEDE+ C
Sbjct: 264 VDCITGEDEVGC 275
Score = 44.0 bits (99), Expect = 0.005
Identities = 21/79 (26%), Positives = 39/79 (49%), Gaps = 10/79 (12%)
Query: 349 DEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNR 408
D + C + + + + CDG+ DC + DE+ C+ +C+ + C+ C+
Sbjct: 207 DFFQCVNGKYISQMKACDGINDCGDQSDELCCK-ACQGKGFHCKSGV---------CIPS 256
Query: 409 KHVCDGMKDCPRGDDEERC 427
++ C+G DC G+DE C
Sbjct: 257 QYQCNGEVDCITGEDEVGC 275
Score = 38.3 bits (85), Expect = 0.25
Identities = 14/35 (40%), Positives = 19/35 (54%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSC 297
C F CK+ C+P +QC+G+ DC DE C
Sbjct: 241 CQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGC 275
>Y00318-1|CAA68416.1| 565|Homo sapiens protein ( Human mRNA for
complement control protein factor I. ).
Length = 565
Score = 69.7 bits (163), Expect = 9e-11
Identities = 30/71 (42%), Positives = 40/71 (56%), Gaps = 4/71 (5%)
Query: 268 FECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNER 327
F+C N K + + CDG NDCGD +DE C +C F C G CIP +++C+ E
Sbjct: 209 FQCVNGKYISQMKACDGINDCGDQSDELCCK----ACQGKGFHCKSGVCIPSQYQCNGEV 264
Query: 328 DCADGGDELNC 338
DC G DE+ C
Sbjct: 265 DCITGEDEVGC 275
Score = 56.8 bits (131), Expect = 7e-07
Identities = 27/72 (37%), Positives = 35/72 (48%), Gaps = 5/72 (6%)
Query: 309 FKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGV 368
F+C +GK I + CD DC D DEL CK C + C C+ + C+G
Sbjct: 209 FQCVNGKYISQMKACDGINDCGDQSDELCCKA-----CQGKGFHCKSGVCIPSQYQCNGE 263
Query: 369 RDCTNGEDEMNC 380
DC GEDE+ C
Sbjct: 264 VDCITGEDEVGC 275
Score = 44.0 bits (99), Expect = 0.005
Identities = 21/79 (26%), Positives = 39/79 (49%), Gaps = 10/79 (12%)
Query: 349 DEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNR 408
D + C + + + + CDG+ DC + DE+ C+ +C+ + C+ C+
Sbjct: 207 DFFQCVNGKYISQMKACDGINDCGDQSDELCCK-ACQGKGFHCKSGV---------CIPS 256
Query: 409 KHVCDGMKDCPRGDDEERC 427
++ C+G DC G+DE C
Sbjct: 257 QYQCNGEVDCITGEDEVGC 275
Score = 38.3 bits (85), Expect = 0.25
Identities = 14/35 (40%), Positives = 19/35 (54%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSC 297
C F CK+ C+P +QC+G+ DC DE C
Sbjct: 241 CQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGC 275
>X05495-1|CAA29045.1| 575|Homo sapiens thrombomodulin protein.
Length = 575
Score = 69.7 bits (163), Expect = 9e-11
Identities = 34/92 (36%), Positives = 43/92 (46%), Gaps = 7/92 (7%)
Query: 418 CPRGD----DEERCPLKRKCSAEEKCEKLCITTYD--GHAACACPMGFLLAEDKYSCRDI 471
CP G D C S + CE C+ D G +C C G+ LA D++ C D+
Sbjct: 267 CPAGAALQADGRSCTASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDV 326
Query: 472 DECMYEQDPVCSQTCSNTVGSFRCGCMTGYIL 503
D+C+ E P C Q C NT G F C C Y L
Sbjct: 327 DDCILEPSP-CPQRCVNTQGGFECHCYPNYDL 357
Score = 52.4 bits (120), Expect = 1e-05
Identities = 60/224 (26%), Positives = 94/224 (41%), Gaps = 30/224 (13%)
Query: 294 EDSCPMVPGS----CNAGEFKCNDGK-CIPERWRCDN---ERDCADGGDE---LNCKPNS 342
E +C +PG+ C AG DG+ C + N E C D+ +C +
Sbjct: 253 EHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCVPNPDQPGSYSCMCET 312
Query: 343 IRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTC-RPQEHLM-S 399
+ D++ C D C+L+ C T G E +C + + C P + +
Sbjct: 313 GYRLAADQHRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDGECVEPVDPCFRA 372
Query: 400 NAFRNC--VNR-KHVC---DGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAAC 453
N C +N+ ++C +G P + RC + C+ + C C + A+C
Sbjct: 373 NCEYQCQPLNQTSYLCVCAEGFAPIPH--EPHRCQMF--CN-QTACPADCDP--NTQASC 425
Query: 454 ACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGC 497
CP G++L +D + C DIDEC E CS C N G+F C C
Sbjct: 426 ECPEGYIL-DDGFICTDIDEC--ENGGFCSGVCHNLPGTFECIC 466
Score = 47.2 bits (107), Expect = 5e-04
Identities = 17/36 (47%), Positives = 19/36 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C NGGC H C PG C CP G L DG++C
Sbjct: 245 CSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSC 280
Score = 43.2 bits (97), Expect = 0.009
Identities = 30/105 (28%), Positives = 38/105 (36%), Gaps = 7/105 (6%)
Query: 411 VCDGMKDCPRGDDEERCPLKRKCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCR 469
+C +G P CS E CE C G C CP G L D SC
Sbjct: 223 MCTAPPGAVQGHWAREAPGAWDCSVENGGCEHAC-NAIPGAPRCQCPAGAALQADGRSCT 281
Query: 470 DIDECMYEQDPVCSQTC---SNTVGSFRCGCMTGYILRPDERSCK 511
+ +C C + GS+ C C TGY L D+ C+
Sbjct: 282 A--SATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCE 324
Score = 38.7 bits (86), Expect = 0.19
Identities = 17/53 (32%), Positives = 22/53 (41%), Gaps = 3/53 (5%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTGMPFE---KSTTDQTPKKCKSHPEEFLI 1371
C +NGGC H C P C CP G + +S T + C E F +
Sbjct: 245 CSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCV 297
>S82451-1|AAB37459.1| 1821|Homo sapiens latent transforming growth
factor-beta-binding protein-2 protein.
Length = 1821
Score = 69.7 bits (163), Expect = 9e-11
Identities = 69/252 (27%), Positives = 95/252 (37%), Gaps = 25/252 (9%)
Query: 270 CKNTKCVPKD--FQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPER--WRCDN 325
C + KC + F+C + +DE C V C A C G C+ + C
Sbjct: 1020 CAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVD-EC-ASRASCPTGLCLNTEGSFACSA 1077
Query: 326 ERDCADGG--DELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVS 383
C +G +E + C+ C C T +DC G S
Sbjct: 1078 ---CENGYWVNEDGTACEDLDECAFPG-VCPSGVCT-NTAGSFSCKDCDGGYRPSPLGDS 1132
Query: 384 CEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEER---CPLKRKCSAEEKCE 440
CE+ PQ + +N V + C CP+G C +C EE C
Sbjct: 1133 CEDVDECEDPQSSCLGGECKNTVG-SYQCL----CPQGFQLANGTVCEDVNECMGEEHCA 1187
Query: 441 KL--CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCM 498
C+ ++ G C C GF+ AE SC+D+DEC DP C NT GSF C C
Sbjct: 1188 PHGECLNSH-GSFFCLCAPGFVSAEGGTSCQDVDECA-TTDPCVGGHCVNTEGSFNCLCE 1245
Query: 499 TGYILRPDERSC 510
TG+ P+ C
Sbjct: 1246 TGFQPSPESGEC 1257
Score = 61.7 bits (143), Expect = 2e-08
Identities = 70/262 (26%), Positives = 97/262 (37%), Gaps = 30/262 (11%)
Query: 270 CKNTKCV--PKDFQC----DG-DNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C + +CV P + C +G G D + C + PG C G KC + + +R
Sbjct: 980 CPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNEC-LTPGVCAHG--KCTN---LEGSFR 1033
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV 382
C E+ DE C+ + C+ +C C L T C NG
Sbjct: 1034 CSCEQGYEVTSDEKGCQ--DVDECA-SRASCPTGLC-LNTEGSFACSACENGYWVNEDGT 1089
Query: 383 SCEEDQYTCRPQEHLMSNAFRNCVNRKHV--CDG-MKDCPRGD---DEERCPLKRKCSAE 436
+CE D C S N CDG + P GD D + C +
Sbjct: 1090 ACE-DLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLG 1148
Query: 437 EKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCG 496
+C+ G C CP GF LA C D++ECM E+ C N+ GSF C
Sbjct: 1149 GECKNTV-----GSYQCLCPQGFQLANGTV-CEDVNECMGEEHCAPHGECLNSHGSFFCL 1202
Query: 497 CMTGYILRPDERSCKPTGESPT 518
C G++ SC+ E T
Sbjct: 1203 CAPGFVSAEGGTSCQDVDECAT 1224
Score = 59.3 bits (137), Expect = 1e-07
Identities = 65/244 (26%), Positives = 95/244 (38%), Gaps = 30/244 (12%)
Query: 270 CKNTKCVPKD-FQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERD 328
C+N V +D C+ ++C CP + AG F C D CD
Sbjct: 1078 CENGYWVNEDGTACEDLDECAF---PGVCPSGVCTNTAGSFSCKD---------CDGGYR 1125
Query: 329 CADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQ 388
+ GD +C+ + C + +C C K + C G N V CE D
Sbjct: 1126 PSPLGD--SCE--DVDECEDPQSSCLGGEC--KNTVGSYQCLCPQGFQLANGTV-CE-DV 1177
Query: 389 YTCRPQEHLMSNAFRNCVNR--KHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEK-LCIT 445
C +EH + C+N C + C +C+ + C C+
Sbjct: 1178 NECMGEEHCAPHG--ECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVN 1235
Query: 446 TYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC-SQTCSNTVGSFRC--GCMTGYI 502
T +G C C GF + + C DIDEC DPVC + C N+ GS+RC GC G+
Sbjct: 1236 T-EGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFH 1294
Query: 503 LRPD 506
+ P+
Sbjct: 1295 MAPN 1298
Score = 52.0 bits (119), Expect = 2e-05
Identities = 63/243 (25%), Positives = 92/243 (37%), Gaps = 36/243 (14%)
Query: 293 DEDSCPMVPGSCNAGEF---------KCNDGKCIPERWRCDNERDCADGGD--ELNC--K 339
D + C PG C+ G+ +C+ G + + C + +C G + C
Sbjct: 930 DINECEQ-PGVCSGGQCTNTEGSYHCECDQGYIMVRKGHCQDINECRHPGTCPDGRCVNS 988
Query: 340 PNSIRNCSLDE-YTCADRRCV-LKTWLCDGV---RDCTNGEDEMNCEVSCEE------DQ 388
P S + +E Y CV + L GV CTN E C SCE+ D+
Sbjct: 989 PGSYTCLACEEGYRGQSGSCVDVNECLTPGVCAHGKCTNLEGSFRC--SCEQGYEVTSDE 1046
Query: 389 YTCRPQEHLMSNAFRN---CVNRKHVCDGMKDCPRG----DDEERCPLKRKCSAEEKCEK 441
C+ + S A C+N + C G +D C +C+ C
Sbjct: 1047 KGCQDVDECASRASCPTGLCLNTEGSF-ACSACENGYWVNEDGTACEDLDECAFPGVCPS 1105
Query: 442 LCITTYDGHAACA-CPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTG 500
T G +C C G+ + SC D+DEC Q C NTVGS++C C G
Sbjct: 1106 GVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQG 1165
Query: 501 YIL 503
+ L
Sbjct: 1166 FQL 1168
Score = 47.6 bits (108), Expect = 4e-04
Identities = 27/83 (32%), Positives = 37/83 (44%), Gaps = 5/83 (6%)
Query: 432 KCSAEEKCEK-LCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP--VCSQT-CS 487
+C CE C+ +G+ C C GF L +C D++EC P +C C
Sbjct: 1736 ECGILNGCENGRCVRVREGYT-CDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCE 1794
Query: 488 NTVGSFRCGCMTGYILRPDERSC 510
NT GS+RC C GY+ C
Sbjct: 1795 NTEGSYRCHCSPGYVAEAGPPHC 1817
Score = 46.8 bits (106), Expect = 7e-04
Identities = 29/104 (27%), Positives = 40/104 (38%), Gaps = 8/104 (7%)
Query: 414 GMKDCPRGD--DEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDI 471
G P GD D + C C + C+ DG C C GF ++ + C D+
Sbjct: 1292 GFHMAPNGDCIDIDECANDTMCGSHGFCDNT-----DGSFRCLCDQGFEISPSGWDCVDV 1346
Query: 472 DECMYEQDPVCSQTCSNTVGSFRCGCMTGY-ILRPDERSCKPTG 514
+EC + C N GSF C C + E C+P G
Sbjct: 1347 NECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRG 1390
Score = 46.4 bits (105), Expect = 0.001
Identities = 71/272 (26%), Positives = 100/272 (36%), Gaps = 47/272 (17%)
Query: 270 CKNTKCVPKDFQCDGD---NDCGD-WTDEDSCPMVPGSCNAGEFKCNDG--KCI-PERWR 322
C NT CDG + GD D D C SC GE K G +C+ P+ ++
Sbjct: 1108 CTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQ 1167
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLK--TWLCDGVRDCTNGEDEMNC 380
N C D + C +E+ C+ ++ C C G
Sbjct: 1168 LANGTVCED-----------VNECMGEEHCAPHGECLNSHGSFFCL----CAPGFVSAEG 1212
Query: 381 EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCE 440
SC+ D C + + +CVN +G +C + P +C ++CE
Sbjct: 1213 GTSCQ-DVDECATTDPCVGG---HCVNT----EGSFNCLCETGFQPSPESGECVDIDECE 1264
Query: 441 K----LCIT----TYDGHAACA--CPMGFLLAEDKYSCRDIDECMYEQDPVCSQT--CSN 488
+C T G C C GF +A + C DIDEC D +C C N
Sbjct: 1265 DYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNG-DCIDIDECA--NDTMCGSHGFCDN 1321
Query: 489 TVGSFRCGCMTGYILRPDERSCKPTGESPTLL 520
T GSFRC C G+ + P C E +L
Sbjct: 1322 TDGSFRCLCDQGFEISPSGWDCVDVNECELML 1353
Score = 44.8 bits (101), Expect = 0.003
Identities = 23/62 (37%), Positives = 32/62 (51%), Gaps = 4/62 (6%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGY 501
C+ DG+ C C G+ L + C D +EC+ +DP + C N VGS+ C C GY
Sbjct: 861 CVNLPDGYR-CVCSPGYQLHPSQAYCTDDNECL--RDPCKGKGRCINRVGSYSCFCYPGY 917
Query: 502 IL 503
L
Sbjct: 918 TL 919
Score = 44.4 bits (100), Expect = 0.004
Identities = 29/90 (32%), Positives = 36/90 (40%), Gaps = 5/90 (5%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGY 501
C+ T G+ C C GF C D DEC QD C C NT GSF C C
Sbjct: 1502 CLNTVPGYV-CLCNPGFHYDASHKKCEDHDEC---QDLACENGECVNTEGSFHCFCSPPL 1557
Query: 502 ILRPDERSCKPTGESPTLLFSNRIGIRQVW 531
L ++ C + S L + I + W
Sbjct: 1558 TLDLSQQRCMNSTSSTEDLPDHDIHMDICW 1587
Score = 41.1 bits (92), Expect = 0.035
Identities = 28/96 (29%), Positives = 39/96 (40%), Gaps = 7/96 (7%)
Query: 425 ERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ 484
+ C +C C T +G C C G+++ K C+DI+EC + C
Sbjct: 926 QECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVR-KGHCQDINECRH--PGTCPD 982
Query: 485 -TCSNTVGSFRC-GCMTGYILRPDERSCKPTGESPT 518
C N+ GS+ C C GY R SC E T
Sbjct: 983 GRCVNSPGSYTCLACEEGY--RGQSGSCVDVNECLT 1016
Score = 37.9 bits (84), Expect = 0.33
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 4/57 (7%)
Query: 455 CPMGFLLAEDKYSCRDIDECMYEQDPVCSQT-CSNTVGSFRCGCMTGYILRPDERSC 510
CP G+ + C+DI+EC+ +C C NT GS+ C C G +L P C
Sbjct: 608 CPQGYKRLNLTH-CQDINECLTLG--LCKDAECVNTRGSYLCTCRPGLMLDPSRSRC 661
Score = 35.1 bits (77), Expect = 2.3
Identities = 17/46 (36%), Positives = 19/46 (41%), Gaps = 1/46 (2%)
Query: 471 IDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
ID C VC TC N +RC C GY L P + C E
Sbjct: 845 IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNE 890
>M16552-1|AAB59508.1| 575|Homo sapiens THBD protein.
Length = 575
Score = 69.7 bits (163), Expect = 9e-11
Identities = 34/92 (36%), Positives = 43/92 (46%), Gaps = 7/92 (7%)
Query: 418 CPRGD----DEERCPLKRKCSAEEKCEKLCITTYD--GHAACACPMGFLLAEDKYSCRDI 471
CP G D C S + CE C+ D G +C C G+ LA D++ C D+
Sbjct: 267 CPAGAALQADGRSCTASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDV 326
Query: 472 DECMYEQDPVCSQTCSNTVGSFRCGCMTGYIL 503
D+C+ E P C Q C NT G F C C Y L
Sbjct: 327 DDCILEPSP-CPQRCVNTQGGFECHCYPNYDL 357
Score = 52.4 bits (120), Expect = 1e-05
Identities = 60/224 (26%), Positives = 94/224 (41%), Gaps = 30/224 (13%)
Query: 294 EDSCPMVPGS----CNAGEFKCNDGK-CIPERWRCDN---ERDCADGGDE---LNCKPNS 342
E +C +PG+ C AG DG+ C + N E C D+ +C +
Sbjct: 253 EHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCVPNPDQPGSYSCMCET 312
Query: 343 IRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTC-RPQEHLM-S 399
+ D++ C D C+L+ C T G E +C + + C P + +
Sbjct: 313 GYRLAADQHRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDGECVEPVDPCFRA 372
Query: 400 NAFRNC--VNR-KHVC---DGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAAC 453
N C +N+ ++C +G P + RC + C+ + C C + A+C
Sbjct: 373 NCEYQCQPLNQTSYLCVCAEGFAPIPH--EPHRCQMF--CN-QTACPADCDP--NTQASC 425
Query: 454 ACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGC 497
CP G++L +D + C DIDEC E CS C N G+F C C
Sbjct: 426 ECPEGYIL-DDGFICTDIDEC--ENGGFCSGVCHNLPGTFECIC 466
Score = 47.2 bits (107), Expect = 5e-04
Identities = 17/36 (47%), Positives = 19/36 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C NGGC H C PG C CP G L DG++C
Sbjct: 245 CSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSC 280
Score = 43.2 bits (97), Expect = 0.009
Identities = 30/105 (28%), Positives = 38/105 (36%), Gaps = 7/105 (6%)
Query: 411 VCDGMKDCPRGDDEERCPLKRKCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCR 469
+C +G P CS E CE C G C CP G L D SC
Sbjct: 223 MCTAPPGAVQGHWAREAPGAWDCSVENGGCEHAC-NAIPGAPRCQCPAGAALQADGRSCT 281
Query: 470 DIDECMYEQDPVCSQTC---SNTVGSFRCGCMTGYILRPDERSCK 511
+ +C C + GS+ C C TGY L D+ C+
Sbjct: 282 A--SATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCE 324
Score = 38.7 bits (86), Expect = 0.19
Identities = 17/53 (32%), Positives = 22/53 (41%), Gaps = 3/53 (5%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTGMPFE---KSTTDQTPKKCKSHPEEFLI 1371
C +NGGC H C P C CP G + +S T + C E F +
Sbjct: 245 CSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCV 297
>J02973-1|AAA61175.1| 575|Homo sapiens THBD protein.
Length = 575
Score = 69.7 bits (163), Expect = 9e-11
Identities = 34/92 (36%), Positives = 43/92 (46%), Gaps = 7/92 (7%)
Query: 418 CPRGD----DEERCPLKRKCSAEEKCEKLCITTYD--GHAACACPMGFLLAEDKYSCRDI 471
CP G D C S + CE C+ D G +C C G+ LA D++ C D+
Sbjct: 267 CPAGAALQADGRSCTASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDV 326
Query: 472 DECMYEQDPVCSQTCSNTVGSFRCGCMTGYIL 503
D+C+ E P C Q C NT G F C C Y L
Sbjct: 327 DDCILEPSP-CPQRCVNTQGGFECHCYPNYDL 357
Score = 52.4 bits (120), Expect = 1e-05
Identities = 60/224 (26%), Positives = 94/224 (41%), Gaps = 30/224 (13%)
Query: 294 EDSCPMVPGS----CNAGEFKCNDGK-CIPERWRCDN---ERDCADGGDE---LNCKPNS 342
E +C +PG+ C AG DG+ C + N E C D+ +C +
Sbjct: 253 EHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCVPNPDQPGSYSCMCET 312
Query: 343 IRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTC-RPQEHLM-S 399
+ D++ C D C+L+ C T G E +C + + C P + +
Sbjct: 313 GYRLAADQHRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDGECVEPVDPCFRA 372
Query: 400 NAFRNC--VNR-KHVC---DGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAAC 453
N C +N+ ++C +G P + RC + C+ + C C + A+C
Sbjct: 373 NCEYQCQPLNQTSYLCVCAEGFAPIPH--EPHRCQMF--CN-QTACPADCDP--NTQASC 425
Query: 454 ACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGC 497
CP G++L +D + C DIDEC E CS C N G+F C C
Sbjct: 426 ECPEGYIL-DDGFICTDIDEC--ENGGFCSGVCHNLPGTFECIC 466
Score = 47.2 bits (107), Expect = 5e-04
Identities = 17/36 (47%), Positives = 19/36 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C NGGC H C PG C CP G L DG++C
Sbjct: 245 CSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSC 280
Score = 43.2 bits (97), Expect = 0.009
Identities = 30/105 (28%), Positives = 38/105 (36%), Gaps = 7/105 (6%)
Query: 411 VCDGMKDCPRGDDEERCPLKRKCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCR 469
+C +G P CS E CE C G C CP G L D SC
Sbjct: 223 MCTAPPGAVQGHWAREAPGAWDCSVENGGCEHAC-NAIPGAPRCQCPAGAALQADGRSCT 281
Query: 470 DIDECMYEQDPVCSQTC---SNTVGSFRCGCMTGYILRPDERSCK 511
+ +C C + GS+ C C TGY L D+ C+
Sbjct: 282 A--SATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCE 324
Score = 38.7 bits (86), Expect = 0.19
Identities = 17/53 (32%), Positives = 22/53 (41%), Gaps = 3/53 (5%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTGMPFE---KSTTDQTPKKCKSHPEEFLI 1371
C +NGGC H C P C CP G + +S T + C E F +
Sbjct: 245 CSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCV 297
>J02770-1|AAA52455.1| 583|Homo sapiens IF protein.
Length = 583
Score = 69.7 bits (163), Expect = 9e-11
Identities = 30/71 (42%), Positives = 40/71 (56%), Gaps = 4/71 (5%)
Query: 268 FECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNER 327
F+C N K + + CDG NDCGD +DE C +C F C G CIP +++C+ E
Sbjct: 227 FQCVNGKYISQMKACDGINDCGDQSDELCCK----ACQGKGFHCKSGVCIPSQYQCNGEV 282
Query: 328 DCADGGDELNC 338
DC G DE+ C
Sbjct: 283 DCITGEDEVGC 293
Score = 56.8 bits (131), Expect = 7e-07
Identities = 27/72 (37%), Positives = 35/72 (48%), Gaps = 5/72 (6%)
Query: 309 FKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGV 368
F+C +GK I + CD DC D DEL CK C + C C+ + C+G
Sbjct: 227 FQCVNGKYISQMKACDGINDCGDQSDELCCKA-----CQGKGFHCKSGVCIPSQYQCNGE 281
Query: 369 RDCTNGEDEMNC 380
DC GEDE+ C
Sbjct: 282 VDCITGEDEVGC 293
Score = 44.0 bits (99), Expect = 0.005
Identities = 21/79 (26%), Positives = 39/79 (49%), Gaps = 10/79 (12%)
Query: 349 DEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNR 408
D + C + + + + CDG+ DC + DE+ C+ +C+ + C+ C+
Sbjct: 225 DFFQCVNGKYISQMKACDGINDCGDQSDELCCK-ACQGKGFHCKSGV---------CIPS 274
Query: 409 KHVCDGMKDCPRGDDEERC 427
++ C+G DC G+DE C
Sbjct: 275 QYQCNGEVDCITGEDEVGC 293
Score = 38.3 bits (85), Expect = 0.25
Identities = 14/35 (40%), Positives = 19/35 (54%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSC 297
C F CK+ C+P +QC+G+ DC DE C
Sbjct: 259 CQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGC 293
>D00210-1|BAA00149.1| 575|Homo sapiens thrombomodulin precursor
protein.
Length = 575
Score = 69.7 bits (163), Expect = 9e-11
Identities = 34/92 (36%), Positives = 43/92 (46%), Gaps = 7/92 (7%)
Query: 418 CPRGD----DEERCPLKRKCSAEEKCEKLCITTYD--GHAACACPMGFLLAEDKYSCRDI 471
CP G D C S + CE C+ D G +C C G+ LA D++ C D+
Sbjct: 267 CPAGAALQADGRSCTASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDV 326
Query: 472 DECMYEQDPVCSQTCSNTVGSFRCGCMTGYIL 503
D+C+ E P C Q C NT G F C C Y L
Sbjct: 327 DDCILEPSP-CPQRCVNTQGGFECHCYPNYDL 357
Score = 52.4 bits (120), Expect = 1e-05
Identities = 60/224 (26%), Positives = 94/224 (41%), Gaps = 30/224 (13%)
Query: 294 EDSCPMVPGS----CNAGEFKCNDGK-CIPERWRCDN---ERDCADGGDE---LNCKPNS 342
E +C +PG+ C AG DG+ C + N E C D+ +C +
Sbjct: 253 EHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCVPNPDQPGSYSCMCET 312
Query: 343 IRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTC-RPQEHLM-S 399
+ D++ C D C+L+ C T G E +C + + C P + +
Sbjct: 313 GYRLAADQHRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDGECVEPVDPCFRA 372
Query: 400 NAFRNC--VNR-KHVC---DGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAAC 453
N C +N+ ++C +G P + RC + C+ + C C + A+C
Sbjct: 373 NCEYQCQPLNQTSYLCVCAEGFAPIPH--EPHRCQMF--CN-QTACPADCDP--NTQASC 425
Query: 454 ACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGC 497
CP G++L +D + C DIDEC E CS C N G+F C C
Sbjct: 426 ECPEGYIL-DDGFICTDIDEC--ENGGFCSGVCHNLPGTFECIC 466
Score = 47.2 bits (107), Expect = 5e-04
Identities = 17/36 (47%), Positives = 19/36 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C NGGC H C PG C CP G L DG++C
Sbjct: 245 CSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSC 280
Score = 43.2 bits (97), Expect = 0.009
Identities = 30/105 (28%), Positives = 38/105 (36%), Gaps = 7/105 (6%)
Query: 411 VCDGMKDCPRGDDEERCPLKRKCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCR 469
+C +G P CS E CE C G C CP G L D SC
Sbjct: 223 MCTAPPGAVQGHWAREAPGAWDCSVENGGCEHAC-NAIPGAPRCQCPAGAALQADGRSCT 281
Query: 470 DIDECMYEQDPVCSQTC---SNTVGSFRCGCMTGYILRPDERSCK 511
+ +C C + GS+ C C TGY L D+ C+
Sbjct: 282 A--SATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCE 324
Score = 38.7 bits (86), Expect = 0.19
Identities = 17/53 (32%), Positives = 22/53 (41%), Gaps = 3/53 (5%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTGMPFE---KSTTDQTPKKCKSHPEEFLI 1371
C +NGGC H C P C CP G + +S T + C E F +
Sbjct: 245 CSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCV 297
>CR457174-1|CAG33455.1| 282|Homo sapiens 8D6A protein.
Length = 282
Score = 69.7 bits (163), Expect = 9e-11
Identities = 48/148 (32%), Positives = 67/148 (45%), Gaps = 12/148 (8%)
Query: 263 CAEIDFECKNTK-CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
C F+C+ + CVP ++CD D DC D +DE+ C + P C + +C +P
Sbjct: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEP--CTQ-KGQCPPPPGLP--C 108
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCA-DRRCVLKTWLCDGVRDCTNGEDEMNC 380
C DC+ GG + + S C E C C+ TW CDG DC + DE+ C
Sbjct: 109 PCTGVSDCS-GGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGC 167
Query: 381 ---EVSCEEDQYTCRPQEHLMS-NAFRN 404
E+ E D T P L S + RN
Sbjct: 168 GTNEILPEGDATTMGPPVTLESVTSLRN 195
Score = 68.9 bits (161), Expect = 2e-10
Identities = 43/130 (33%), Positives = 60/130 (46%), Gaps = 18/130 (13%)
Query: 302 GSCNAGEFKCN-DGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVL 360
GSC +F+C G C+P WRCD + DC+DG DE C+ I C+ + C +
Sbjct: 52 GSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECR---IEPCT-QKGQCPPPPGL- 106
Query: 361 KTWLCDGVRDCTNGEDE--MNC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKD 417
C GV DC+ G D+ NC ++C + C + +C+ CDG D
Sbjct: 107 -PCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSD--------DCIPLTWRCDGHPD 157
Query: 418 CPRGDDEERC 427
CP DE C
Sbjct: 158 CPDSSDELGC 167
Score = 41.9 bits (94), Expect = 0.020
Identities = 21/56 (37%), Positives = 32/56 (57%), Gaps = 4/56 (7%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTV 222
C ++ CI L W CDG DC D SDE+ C T+ ++P +A+ +G +T +V
Sbjct: 139 CTLSDDCIPLTWRCDGHPDCPDSSDELGCG---TNEILPEGDAT-TMGPPVTLESV 190
Score = 40.7 bits (91), Expect = 0.046
Identities = 14/31 (45%), Positives = 19/31 (61%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCDV 197
C ++ +C+ L W CD D DC D SDE C +
Sbjct: 61 CRTSGLCVPLTWRCDRDLDCSDGSDEEECRI 91
>BC078659-1|AAH78659.1| 1821|Homo sapiens latent transforming growth
factor beta binding protein 2 protein.
Length = 1821
Score = 69.7 bits (163), Expect = 9e-11
Identities = 69/252 (27%), Positives = 95/252 (37%), Gaps = 25/252 (9%)
Query: 270 CKNTKCVPKD--FQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPER--WRCDN 325
C + KC + F+C + +DE C V C A C G C+ + C
Sbjct: 1020 CAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVD-EC-ASRASCPTGLCLNTEGSFACSA 1077
Query: 326 ERDCADGG--DELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVS 383
C +G +E + C+ C C T +DC G S
Sbjct: 1078 ---CENGYWVNEDGTACEDLDECAFPG-VCPSGVCT-NTAGSFSCKDCDGGYRPSPLGDS 1132
Query: 384 CEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEER---CPLKRKCSAEEKCE 440
CE+ PQ + +N V + C CP+G C +C EE C
Sbjct: 1133 CEDVDECEDPQSSCLGGECKNTVG-SYQCL----CPQGFQLANGTVCEDVNECMGEEHCA 1187
Query: 441 KL--CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCM 498
C+ ++ G C C GF+ AE SC+D+DEC DP C NT GSF C C
Sbjct: 1188 PHGECLNSH-GSFFCLCAPGFVSAEGGTSCQDVDECA-TTDPCVGGHCVNTEGSFNCLCE 1245
Query: 499 TGYILRPDERSC 510
TG+ P+ C
Sbjct: 1246 TGFQPSPESGEC 1257
Score = 61.7 bits (143), Expect = 2e-08
Identities = 70/262 (26%), Positives = 97/262 (37%), Gaps = 30/262 (11%)
Query: 270 CKNTKCV--PKDFQC----DG-DNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C + +CV P + C +G G D + C + PG C G KC + + +R
Sbjct: 980 CPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNEC-LTPGVCAHG--KCTN---LEGSFR 1033
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV 382
C E+ DE C+ + C+ +C C L T C NG
Sbjct: 1034 CSCEQGYEVTSDEKGCQ--DVDECA-SRASCPTGLC-LNTEGSFACSACENGYWVNEDGT 1089
Query: 383 SCEEDQYTCRPQEHLMSNAFRNCVNRKHV--CDG-MKDCPRGD---DEERCPLKRKCSAE 436
+CE D C S N CDG + P GD D + C +
Sbjct: 1090 ACE-DLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLG 1148
Query: 437 EKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCG 496
+C+ G C CP GF LA C D++ECM E+ C N+ GSF C
Sbjct: 1149 GECKNTV-----GSYQCLCPQGFQLANGTV-CEDVNECMGEEHCAPHGECLNSHGSFFCL 1202
Query: 497 CMTGYILRPDERSCKPTGESPT 518
C G++ SC+ E T
Sbjct: 1203 CAPGFVSAEGGTSCQDVDECAT 1224
Score = 59.3 bits (137), Expect = 1e-07
Identities = 65/244 (26%), Positives = 95/244 (38%), Gaps = 30/244 (12%)
Query: 270 CKNTKCVPKD-FQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERD 328
C+N V +D C+ ++C CP + AG F C D CD
Sbjct: 1078 CENGYWVNEDGTACEDLDECAF---PGVCPSGVCTNTAGSFSCKD---------CDGGYR 1125
Query: 329 CADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQ 388
+ GD +C+ + C + +C C K + C G N V CE D
Sbjct: 1126 PSPLGD--SCE--DVDECEDPQSSCLGGEC--KNTVGSYQCLCPQGFQLANGTV-CE-DV 1177
Query: 389 YTCRPQEHLMSNAFRNCVNR--KHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEK-LCIT 445
C +EH + C+N C + C +C+ + C C+
Sbjct: 1178 NECMGEEHCAPHG--ECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVN 1235
Query: 446 TYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC-SQTCSNTVGSFRC--GCMTGYI 502
T +G C C GF + + C DIDEC DPVC + C N+ GS+RC GC G+
Sbjct: 1236 T-EGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFH 1294
Query: 503 LRPD 506
+ P+
Sbjct: 1295 MAPN 1298
Score = 52.0 bits (119), Expect = 2e-05
Identities = 63/243 (25%), Positives = 92/243 (37%), Gaps = 36/243 (14%)
Query: 293 DEDSCPMVPGSCNAGEF---------KCNDGKCIPERWRCDNERDCADGGD--ELNC--K 339
D + C PG C+ G+ +C+ G + + C + +C G + C
Sbjct: 930 DINECEQ-PGVCSGGQCTNTEGSYHCECDQGYIMVRKGHCQDINECRHPGTCPDGRCVNS 988
Query: 340 PNSIRNCSLDE-YTCADRRCV-LKTWLCDGV---RDCTNGEDEMNCEVSCEE------DQ 388
P S + +E Y CV + L GV CTN E C SCE+ D+
Sbjct: 989 PGSYTCLACEEGYRGQSGSCVDVNECLTPGVCAHGKCTNLEGSFRC--SCEQGYEVTSDE 1046
Query: 389 YTCRPQEHLMSNAFRN---CVNRKHVCDGMKDCPRG----DDEERCPLKRKCSAEEKCEK 441
C+ + S A C+N + C G +D C +C+ C
Sbjct: 1047 KGCQDVDECASRASCPTGLCLNTEGSF-ACSACENGYWVNEDGTACEDLDECAFPGVCPS 1105
Query: 442 LCITTYDGHAACA-CPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTG 500
T G +C C G+ + SC D+DEC Q C NTVGS++C C G
Sbjct: 1106 GVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQG 1165
Query: 501 YIL 503
+ L
Sbjct: 1166 FQL 1168
Score = 47.6 bits (108), Expect = 4e-04
Identities = 27/83 (32%), Positives = 37/83 (44%), Gaps = 5/83 (6%)
Query: 432 KCSAEEKCEK-LCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP--VCSQT-CS 487
+C CE C+ +G+ C C GF L +C D++EC P +C C
Sbjct: 1736 ECGILNGCENGRCVRVREGYT-CDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCE 1794
Query: 488 NTVGSFRCGCMTGYILRPDERSC 510
NT GS+RC C GY+ C
Sbjct: 1795 NTEGSYRCHCSPGYVAEAGPPHC 1817
Score = 46.8 bits (106), Expect = 7e-04
Identities = 29/104 (27%), Positives = 40/104 (38%), Gaps = 8/104 (7%)
Query: 414 GMKDCPRGD--DEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDI 471
G P GD D + C C + C+ DG C C GF ++ + C D+
Sbjct: 1292 GFHMAPNGDCIDIDECANDTMCGSHGFCDNT-----DGSFRCLCDQGFEISPSGWDCVDV 1346
Query: 472 DECMYEQDPVCSQTCSNTVGSFRCGCMTGY-ILRPDERSCKPTG 514
+EC + C N GSF C C + E C+P G
Sbjct: 1347 NECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRG 1390
Score = 46.4 bits (105), Expect = 0.001
Identities = 71/272 (26%), Positives = 100/272 (36%), Gaps = 47/272 (17%)
Query: 270 CKNTKCVPKDFQCDGD---NDCGD-WTDEDSCPMVPGSCNAGEFKCNDG--KCI-PERWR 322
C NT CDG + GD D D C SC GE K G +C+ P+ ++
Sbjct: 1108 CTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQ 1167
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLK--TWLCDGVRDCTNGEDEMNC 380
N C D + C +E+ C+ ++ C C G
Sbjct: 1168 LANGTVCED-----------VNECMGEEHCAPHGECLNSHGSFFCL----CAPGFVSAEG 1212
Query: 381 EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCE 440
SC+ D C + + +CVN +G +C + P +C ++CE
Sbjct: 1213 GTSCQ-DVDECATTDPCVGG---HCVNT----EGSFNCLCETGFQPSPESGECVDIDECE 1264
Query: 441 K----LCIT----TYDGHAACA--CPMGFLLAEDKYSCRDIDECMYEQDPVCSQT--CSN 488
+C T G C C GF +A + C DIDEC D +C C N
Sbjct: 1265 DYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNG-DCIDIDECA--NDTMCGSHGFCDN 1321
Query: 489 TVGSFRCGCMTGYILRPDERSCKPTGESPTLL 520
T GSFRC C G+ + P C E +L
Sbjct: 1322 TDGSFRCLCDQGFEISPSGWDCVDVNECELML 1353
Score = 44.8 bits (101), Expect = 0.003
Identities = 23/62 (37%), Positives = 32/62 (51%), Gaps = 4/62 (6%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGY 501
C+ DG+ C C G+ L + C D +EC+ +DP + C N VGS+ C C GY
Sbjct: 861 CVNLPDGYR-CVCSPGYQLHPSQAYCTDDNECL--RDPCKGKGRCINRVGSYSCFCYPGY 917
Query: 502 IL 503
L
Sbjct: 918 TL 919
Score = 44.4 bits (100), Expect = 0.004
Identities = 29/90 (32%), Positives = 36/90 (40%), Gaps = 5/90 (5%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGY 501
C+ T G+ C C GF C D DEC QD C C NT GSF C C
Sbjct: 1502 CLNTVPGYV-CLCNPGFHYDASHKKCEDHDEC---QDLACENGECVNTEGSFHCFCSPPL 1557
Query: 502 ILRPDERSCKPTGESPTLLFSNRIGIRQVW 531
L ++ C + S L + I + W
Sbjct: 1558 TLDLSQQRCMNSTSSTEDLPDHDIHMDICW 1587
Score = 41.1 bits (92), Expect = 0.035
Identities = 28/96 (29%), Positives = 39/96 (40%), Gaps = 7/96 (7%)
Query: 425 ERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ 484
+ C +C C T +G C C G+++ K C+DI+EC + C
Sbjct: 926 QECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVR-KGHCQDINECRH--PGTCPD 982
Query: 485 -TCSNTVGSFRC-GCMTGYILRPDERSCKPTGESPT 518
C N+ GS+ C C GY R SC E T
Sbjct: 983 GRCVNSPGSYTCLACEEGY--RGQSGSCVDVNECLT 1016
Score = 37.9 bits (84), Expect = 0.33
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 4/57 (7%)
Query: 455 CPMGFLLAEDKYSCRDIDECMYEQDPVCSQT-CSNTVGSFRCGCMTGYILRPDERSC 510
CP G+ + C+DI+EC+ +C C NT GS+ C C G +L P C
Sbjct: 608 CPQGYKRLNLTH-CQDINECLTLG--LCKDAECVNTRGSYLCTCRPGLMLDPSRSRC 661
Score = 35.1 bits (77), Expect = 2.3
Identities = 17/46 (36%), Positives = 19/46 (41%), Gaps = 1/46 (2%)
Query: 471 IDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
ID C VC TC N +RC C GY L P + C E
Sbjct: 845 IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNE 890
>BC053357-1|AAH53357.1| 575|Homo sapiens thrombomodulin protein.
Length = 575
Score = 69.7 bits (163), Expect = 9e-11
Identities = 34/92 (36%), Positives = 43/92 (46%), Gaps = 7/92 (7%)
Query: 418 CPRGD----DEERCPLKRKCSAEEKCEKLCITTYD--GHAACACPMGFLLAEDKYSCRDI 471
CP G D C S + CE C+ D G +C C G+ LA D++ C D+
Sbjct: 267 CPAGAALQADGRSCTASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDV 326
Query: 472 DECMYEQDPVCSQTCSNTVGSFRCGCMTGYIL 503
D+C+ E P C Q C NT G F C C Y L
Sbjct: 327 DDCILEPSP-CPQRCVNTQGGFECHCYPNYDL 357
Score = 52.4 bits (120), Expect = 1e-05
Identities = 60/224 (26%), Positives = 94/224 (41%), Gaps = 30/224 (13%)
Query: 294 EDSCPMVPGS----CNAGEFKCNDGK-CIPERWRCDN---ERDCADGGDE---LNCKPNS 342
E +C +PG+ C AG DG+ C + N E C D+ +C +
Sbjct: 253 EHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCVPNPDQPGSYSCMCET 312
Query: 343 IRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTC-RPQEHLM-S 399
+ D++ C D C+L+ C T G E +C + + C P + +
Sbjct: 313 GYRLAADQHRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDGECVEPVDPCFRA 372
Query: 400 NAFRNC--VNR-KHVC---DGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAAC 453
N C +N+ ++C +G P + RC + C+ + C C + A+C
Sbjct: 373 NCEYQCQPLNQTSYLCVCAEGFAPIPH--EPHRCQMF--CN-QTACPADCDP--NTQASC 425
Query: 454 ACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGC 497
CP G++L +D + C DIDEC E CS C N G+F C C
Sbjct: 426 ECPEGYIL-DDGFICTDIDEC--ENGGFCSGVCHNLPGTFECIC 466
Score = 47.2 bits (107), Expect = 5e-04
Identities = 17/36 (47%), Positives = 19/36 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C NGGC H C PG C CP G L DG++C
Sbjct: 245 CSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSC 280
Score = 43.2 bits (97), Expect = 0.009
Identities = 30/105 (28%), Positives = 38/105 (36%), Gaps = 7/105 (6%)
Query: 411 VCDGMKDCPRGDDEERCPLKRKCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCR 469
+C +G P CS E CE C G C CP G L D SC
Sbjct: 223 MCTAPPGAVQGHWAREAPGAWDCSVENGGCEHAC-NAIPGAPRCQCPAGAALQADGRSCT 281
Query: 470 DIDECMYEQDPVCSQTC---SNTVGSFRCGCMTGYILRPDERSCK 511
+ +C C + GS+ C C TGY L D+ C+
Sbjct: 282 A--SATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCE 324
Score = 38.7 bits (86), Expect = 0.19
Identities = 17/53 (32%), Positives = 22/53 (41%), Gaps = 3/53 (5%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTGMPFE---KSTTDQTPKKCKSHPEEFLI 1371
C +NGGC H C P C CP G + +S T + C E F +
Sbjct: 245 CSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCV 297
>BC035602-1|AAH35602.2| 575|Homo sapiens thrombomodulin protein.
Length = 575
Score = 69.7 bits (163), Expect = 9e-11
Identities = 34/92 (36%), Positives = 43/92 (46%), Gaps = 7/92 (7%)
Query: 418 CPRGD----DEERCPLKRKCSAEEKCEKLCITTYD--GHAACACPMGFLLAEDKYSCRDI 471
CP G D C S + CE C+ D G +C C G+ LA D++ C D+
Sbjct: 267 CPAGAALQADGRSCTASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDV 326
Query: 472 DECMYEQDPVCSQTCSNTVGSFRCGCMTGYIL 503
D+C+ E P C Q C NT G F C C Y L
Sbjct: 327 DDCILEPSP-CPQRCVNTQGGFECHCYPNYDL 357
Score = 52.4 bits (120), Expect = 1e-05
Identities = 60/224 (26%), Positives = 94/224 (41%), Gaps = 30/224 (13%)
Query: 294 EDSCPMVPGS----CNAGEFKCNDGK-CIPERWRCDN---ERDCADGGDE---LNCKPNS 342
E +C +PG+ C AG DG+ C + N E C D+ +C +
Sbjct: 253 EHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCVPNPDQPGSYSCMCET 312
Query: 343 IRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTC-RPQEHLM-S 399
+ D++ C D C+L+ C T G E +C + + C P + +
Sbjct: 313 GYRLAADQHRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDGECVEPVDPCFRA 372
Query: 400 NAFRNC--VNR-KHVC---DGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAAC 453
N C +N+ ++C +G P + RC + C+ + C C + A+C
Sbjct: 373 NCEYQCQPLNQTSYLCVCAEGFAPIPH--EPHRCQMF--CN-QTACPADCDP--NTQASC 425
Query: 454 ACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGC 497
CP G++L +D + C DIDEC E CS C N G+F C C
Sbjct: 426 ECPEGYIL-DDGFICTDIDEC--ENGGFCSGVCHNLPGTFECIC 466
Score = 47.2 bits (107), Expect = 5e-04
Identities = 17/36 (47%), Positives = 19/36 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C NGGC H C PG C CP G L DG++C
Sbjct: 245 CSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSC 280
Score = 43.2 bits (97), Expect = 0.009
Identities = 30/105 (28%), Positives = 38/105 (36%), Gaps = 7/105 (6%)
Query: 411 VCDGMKDCPRGDDEERCPLKRKCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCR 469
+C +G P CS E CE C G C CP G L D SC
Sbjct: 223 MCTAPPGAVQGHWAREAPGAWDCSVENGGCEHAC-NAIPGAPRCQCPAGAALQADGRSCT 281
Query: 470 DIDECMYEQDPVCSQTC---SNTVGSFRCGCMTGYILRPDERSCK 511
+ +C C + GS+ C C TGY L D+ C+
Sbjct: 282 A--SATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCE 324
Score = 38.7 bits (86), Expect = 0.19
Identities = 17/53 (32%), Positives = 22/53 (41%), Gaps = 3/53 (5%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTGMPFE---KSTTDQTPKKCKSHPEEFLI 1371
C +NGGC H C P C CP G + +S T + C E F +
Sbjct: 245 CSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCV 297
>BC020718-1|AAH20718.1| 377|Homo sapiens CFI protein protein.
Length = 377
Score = 69.7 bits (163), Expect = 9e-11
Identities = 30/71 (42%), Positives = 40/71 (56%), Gaps = 4/71 (5%)
Query: 268 FECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNER 327
F+C N K + + CDG NDCGD +DE C +C F C G CIP +++C+ E
Sbjct: 227 FQCVNGKYISQMKACDGINDCGDQSDELCCK----ACQGKGFHCKSGVCIPSQYQCNGEV 282
Query: 328 DCADGGDELNC 338
DC G DE+ C
Sbjct: 283 DCITGEDEVGC 293
Score = 56.8 bits (131), Expect = 7e-07
Identities = 27/72 (37%), Positives = 35/72 (48%), Gaps = 5/72 (6%)
Query: 309 FKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGV 368
F+C +GK I + CD DC D DEL CK C + C C+ + C+G
Sbjct: 227 FQCVNGKYISQMKACDGINDCGDQSDELCCKA-----CQGKGFHCKSGVCIPSQYQCNGE 281
Query: 369 RDCTNGEDEMNC 380
DC GEDE+ C
Sbjct: 282 VDCITGEDEVGC 293
Score = 44.0 bits (99), Expect = 0.005
Identities = 21/79 (26%), Positives = 39/79 (49%), Gaps = 10/79 (12%)
Query: 349 DEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNR 408
D + C + + + + CDG+ DC + DE+ C+ +C+ + C+ C+
Sbjct: 225 DFFQCVNGKYISQMKACDGINDCGDQSDELCCK-ACQGKGFHCKSGV---------CIPS 274
Query: 409 KHVCDGMKDCPRGDDEERC 427
++ C+G DC G+DE C
Sbjct: 275 QYQCNGEVDCITGEDEVGC 293
Score = 38.3 bits (85), Expect = 0.25
Identities = 14/35 (40%), Positives = 19/35 (54%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSC 297
C F CK+ C+P +QC+G+ DC DE C
Sbjct: 259 CQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGC 293
>BC007083-1|AAH07083.1| 282|Homo sapiens CD320 molecule protein.
Length = 282
Score = 69.7 bits (163), Expect = 9e-11
Identities = 48/148 (32%), Positives = 67/148 (45%), Gaps = 12/148 (8%)
Query: 263 CAEIDFECKNTK-CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
C F+C+ + CVP ++CD D DC D +DE+ C + P C + +C +P
Sbjct: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEP--CTQ-KGQCPPPPGLP--C 108
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCA-DRRCVLKTWLCDGVRDCTNGEDEMNC 380
C DC+ GG + + S C E C C+ TW CDG DC + DE+ C
Sbjct: 109 PCTGVSDCS-GGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGC 167
Query: 381 ---EVSCEEDQYTCRPQEHLMS-NAFRN 404
E+ E D T P L S + RN
Sbjct: 168 GTNEILPEGDATTMGPPVTLESVTSLRN 195
Score = 68.9 bits (161), Expect = 2e-10
Identities = 43/130 (33%), Positives = 60/130 (46%), Gaps = 18/130 (13%)
Query: 302 GSCNAGEFKCN-DGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVL 360
GSC +F+C G C+P WRCD + DC+DG DE C+ I C+ + C +
Sbjct: 52 GSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECR---IEPCT-QKGQCPPPPGL- 106
Query: 361 KTWLCDGVRDCTNGEDE--MNC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKD 417
C GV DC+ G D+ NC ++C + C + +C+ CDG D
Sbjct: 107 -PCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSD--------DCIPLTWRCDGHPD 157
Query: 418 CPRGDDEERC 427
CP DE C
Sbjct: 158 CPDSSDELGC 167
Score = 41.9 bits (94), Expect = 0.020
Identities = 21/56 (37%), Positives = 32/56 (57%), Gaps = 4/56 (7%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTV 222
C ++ CI L W CDG DC D SDE+ C T+ ++P +A+ +G +T +V
Sbjct: 139 CTLSDDCIPLTWRCDGHPDCPDSSDELGCG---TNEILPEGDAT-TMGPPVTLESV 190
Score = 40.7 bits (91), Expect = 0.046
Identities = 14/31 (45%), Positives = 19/31 (61%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCDV 197
C ++ +C+ L W CD D DC D SDE C +
Sbjct: 61 CRTSGLCVPLTWRCDRDLDCSDGSDEEECRI 91
>BC000668-1|AAH00668.1| 282|Homo sapiens CD320 molecule protein.
Length = 282
Score = 69.7 bits (163), Expect = 9e-11
Identities = 48/148 (32%), Positives = 67/148 (45%), Gaps = 12/148 (8%)
Query: 263 CAEIDFECKNTK-CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
C F+C+ + CVP ++CD D DC D +DE+ C + P C + +C +P
Sbjct: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEP--CTQ-KGQCPPPPGLP--C 108
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCA-DRRCVLKTWLCDGVRDCTNGEDEMNC 380
C DC+ GG + + S C E C C+ TW CDG DC + DE+ C
Sbjct: 109 PCTGVSDCS-GGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGC 167
Query: 381 ---EVSCEEDQYTCRPQEHLMS-NAFRN 404
E+ E D T P L S + RN
Sbjct: 168 GTNEILPEGDATTMGPPVTLESVTSLRN 195
Score = 68.9 bits (161), Expect = 2e-10
Identities = 43/130 (33%), Positives = 60/130 (46%), Gaps = 18/130 (13%)
Query: 302 GSCNAGEFKCN-DGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVL 360
GSC +F+C G C+P WRCD + DC+DG DE C+ I C+ + C +
Sbjct: 52 GSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECR---IEPCT-QKGQCPPPPGL- 106
Query: 361 KTWLCDGVRDCTNGEDE--MNC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKD 417
C GV DC+ G D+ NC ++C + C + +C+ CDG D
Sbjct: 107 -PCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSD--------DCIPLTWRCDGHPD 157
Query: 418 CPRGDDEERC 427
CP DE C
Sbjct: 158 CPDSSDELGC 167
Score = 41.9 bits (94), Expect = 0.020
Identities = 21/56 (37%), Positives = 32/56 (57%), Gaps = 4/56 (7%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTV 222
C ++ CI L W CDG DC D SDE+ C T+ ++P +A+ +G +T +V
Sbjct: 139 CTLSDDCIPLTWRCDGHPDCPDSSDELGCG---TNEILPEGDAT-TMGPPVTLESV 190
Score = 40.7 bits (91), Expect = 0.046
Identities = 14/31 (45%), Positives = 19/31 (61%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCDV 197
C ++ +C+ L W CD D DC D SDE C +
Sbjct: 61 CRTSGLCVPLTWRCDRDLDCSDGSDEEECRI 91
>AY358420-1|AAQ88786.1| 282|Homo sapiens SGGW198 protein.
Length = 282
Score = 69.7 bits (163), Expect = 9e-11
Identities = 48/148 (32%), Positives = 67/148 (45%), Gaps = 12/148 (8%)
Query: 263 CAEIDFECKNTK-CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
C F+C+ + CVP ++CD D DC D +DE+ C + P C + +C +P
Sbjct: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEP--CTQ-KGQCPPPPGLP--C 108
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCA-DRRCVLKTWLCDGVRDCTNGEDEMNC 380
C DC+ GG + + S C E C C+ TW CDG DC + DE+ C
Sbjct: 109 PCTGVSDCS-GGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGC 167
Query: 381 ---EVSCEEDQYTCRPQEHLMS-NAFRN 404
E+ E D T P L S + RN
Sbjct: 168 GTNEILPEGDATTMGPPVTLESVTSLRN 195
Score = 68.9 bits (161), Expect = 2e-10
Identities = 43/130 (33%), Positives = 60/130 (46%), Gaps = 18/130 (13%)
Query: 302 GSCNAGEFKCN-DGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVL 360
GSC +F+C G C+P WRCD + DC+DG DE C+ I C+ + C +
Sbjct: 52 GSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECR---IEPCT-QKGQCPPPPGL- 106
Query: 361 KTWLCDGVRDCTNGEDE--MNC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKD 417
C GV DC+ G D+ NC ++C + C + +C+ CDG D
Sbjct: 107 -PCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSD--------DCIPLTWRCDGHPD 157
Query: 418 CPRGDDEERC 427
CP DE C
Sbjct: 158 CPDSSDELGC 167
Score = 41.9 bits (94), Expect = 0.020
Identities = 21/56 (37%), Positives = 32/56 (57%), Gaps = 4/56 (7%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTV 222
C ++ CI L W CDG DC D SDE+ C T+ ++P +A+ +G +T +V
Sbjct: 139 CTLSDDCIPLTWRCDGHPDCPDSSDELGCG---TNEILPEGDAT-TMGPPVTLESV 190
Score = 40.7 bits (91), Expect = 0.046
Identities = 14/31 (45%), Positives = 19/31 (61%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCDV 197
C ++ +C+ L W CD D DC D SDE C +
Sbjct: 61 CRTSGLCVPLTWRCDRDLDCSDGSDEEECRI 91
>AL365455-1|CAB97010.1| 282|Homo sapiens 8D6 antigen protein.
Length = 282
Score = 69.7 bits (163), Expect = 9e-11
Identities = 48/148 (32%), Positives = 67/148 (45%), Gaps = 12/148 (8%)
Query: 263 CAEIDFECKNTK-CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
C F+C+ + CVP ++CD D DC D +DE+ C + P C + +C +P
Sbjct: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEP--CTQ-KGQCPPPPGLP--C 108
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCA-DRRCVLKTWLCDGVRDCTNGEDEMNC 380
C DC+ GG + + S C E C C+ TW CDG DC + DE+ C
Sbjct: 109 PCTGVSDCS-GGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGC 167
Query: 381 ---EVSCEEDQYTCRPQEHLMS-NAFRN 404
E+ E D T P L S + RN
Sbjct: 168 GTNEILPEGDATTMGPPVTLESVTSLRN 195
Score = 68.9 bits (161), Expect = 2e-10
Identities = 43/130 (33%), Positives = 60/130 (46%), Gaps = 18/130 (13%)
Query: 302 GSCNAGEFKCN-DGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVL 360
GSC +F+C G C+P WRCD + DC+DG DE C+ I C+ + C +
Sbjct: 52 GSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECR---IEPCT-QKGQCPPPPGL- 106
Query: 361 KTWLCDGVRDCTNGEDE--MNC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKD 417
C GV DC+ G D+ NC ++C + C + +C+ CDG D
Sbjct: 107 -PCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSD--------DCIPLTWRCDGHPD 157
Query: 418 CPRGDDEERC 427
CP DE C
Sbjct: 158 CPDSSDELGC 167
Score = 41.9 bits (94), Expect = 0.020
Identities = 21/56 (37%), Positives = 32/56 (57%), Gaps = 4/56 (7%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTV 222
C ++ CI L W CDG DC D SDE+ C T+ ++P +A+ +G +T +V
Sbjct: 139 CTLSDDCIPLTWRCDGHPDCPDSSDELGCG---TNEILPEGDAT-TMGPPVTLESV 190
Score = 40.7 bits (91), Expect = 0.046
Identities = 14/31 (45%), Positives = 19/31 (61%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCDV 197
C ++ +C+ L W CD D DC D SDE C +
Sbjct: 61 CRTSGLCVPLTWRCDRDLDCSDGSDEEECRI 91
>AL049651-2|CAB51954.1| 575|Homo sapiens thrombomodulin protein.
Length = 575
Score = 69.7 bits (163), Expect = 9e-11
Identities = 34/92 (36%), Positives = 43/92 (46%), Gaps = 7/92 (7%)
Query: 418 CPRGD----DEERCPLKRKCSAEEKCEKLCITTYD--GHAACACPMGFLLAEDKYSCRDI 471
CP G D C S + CE C+ D G +C C G+ LA D++ C D+
Sbjct: 267 CPAGAALQADGRSCTASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDV 326
Query: 472 DECMYEQDPVCSQTCSNTVGSFRCGCMTGYIL 503
D+C+ E P C Q C NT G F C C Y L
Sbjct: 327 DDCILEPSP-CPQRCVNTQGGFECHCYPNYDL 357
Score = 52.4 bits (120), Expect = 1e-05
Identities = 60/224 (26%), Positives = 94/224 (41%), Gaps = 30/224 (13%)
Query: 294 EDSCPMVPGS----CNAGEFKCNDGK-CIPERWRCDN---ERDCADGGDE---LNCKPNS 342
E +C +PG+ C AG DG+ C + N E C D+ +C +
Sbjct: 253 EHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCVPNPDQPGSYSCMCET 312
Query: 343 IRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTC-RPQEHLM-S 399
+ D++ C D C+L+ C T G E +C + + C P + +
Sbjct: 313 GYRLAADQHRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDGECVEPVDPCFRA 372
Query: 400 NAFRNC--VNR-KHVC---DGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAAC 453
N C +N+ ++C +G P + RC + C+ + C C + A+C
Sbjct: 373 NCEYQCQPLNQTSYLCVCAEGFAPIPH--EPHRCQMF--CN-QTACPADCDP--NTQASC 425
Query: 454 ACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGC 497
CP G++L +D + C DIDEC E CS C N G+F C C
Sbjct: 426 ECPEGYIL-DDGFICTDIDEC--ENGGFCSGVCHNLPGTFECIC 466
Score = 47.2 bits (107), Expect = 5e-04
Identities = 17/36 (47%), Positives = 19/36 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C NGGC H C PG C CP G L DG++C
Sbjct: 245 CSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSC 280
Score = 43.2 bits (97), Expect = 0.009
Identities = 30/105 (28%), Positives = 38/105 (36%), Gaps = 7/105 (6%)
Query: 411 VCDGMKDCPRGDDEERCPLKRKCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCR 469
+C +G P CS E CE C G C CP G L D SC
Sbjct: 223 MCTAPPGAVQGHWAREAPGAWDCSVENGGCEHAC-NAIPGAPRCQCPAGAALQADGRSCT 281
Query: 470 DIDECMYEQDPVCSQTC---SNTVGSFRCGCMTGYILRPDERSCK 511
+ +C C + GS+ C C TGY L D+ C+
Sbjct: 282 A--SATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCE 324
Score = 38.7 bits (86), Expect = 0.19
Identities = 17/53 (32%), Positives = 22/53 (41%), Gaps = 3/53 (5%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTGMPFE---KSTTDQTPKKCKSHPEEFLI 1371
C +NGGC H C P C CP G + +S T + C E F +
Sbjct: 245 CSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCV 297
>AK222623-1|BAD96343.1| 282|Homo sapiens 8D6 antigen variant
protein.
Length = 282
Score = 69.7 bits (163), Expect = 9e-11
Identities = 48/148 (32%), Positives = 67/148 (45%), Gaps = 12/148 (8%)
Query: 263 CAEIDFECKNTK-CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
C F+C+ + CVP ++CD D DC D +DE+ C + P C + +C +P
Sbjct: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEP--CTQ-KGQCPPPPGLP--C 108
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCA-DRRCVLKTWLCDGVRDCTNGEDEMNC 380
C DC+ GG + + S C E C C+ TW CDG DC + DE+ C
Sbjct: 109 PCTGVSDCS-GGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGC 167
Query: 381 ---EVSCEEDQYTCRPQEHLMS-NAFRN 404
E+ E D T P L S + RN
Sbjct: 168 GTNEILPEGDATTMGPPVTLESVTSLRN 195
Score = 68.9 bits (161), Expect = 2e-10
Identities = 43/130 (33%), Positives = 60/130 (46%), Gaps = 18/130 (13%)
Query: 302 GSCNAGEFKCN-DGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVL 360
GSC +F+C G C+P WRCD + DC+DG DE C+ I C+ + C +
Sbjct: 52 GSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECR---IEPCT-QKGQCPPPPGL- 106
Query: 361 KTWLCDGVRDCTNGEDE--MNC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKD 417
C GV DC+ G D+ NC ++C + C + +C+ CDG D
Sbjct: 107 -PCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSD--------DCIPLTWRCDGHPD 157
Query: 418 CPRGDDEERC 427
CP DE C
Sbjct: 158 CPDSSDELGC 167
Score = 41.9 bits (94), Expect = 0.020
Identities = 21/56 (37%), Positives = 32/56 (57%), Gaps = 4/56 (7%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTV 222
C ++ CI L W CDG DC D SDE+ C T+ ++P +A+ +G +T +V
Sbjct: 139 CTLSDDCIPLTWRCDGHPDCPDSSDELGCG---TNEILPEGDAT-TMGPPVTLESV 190
Score = 40.7 bits (91), Expect = 0.046
Identities = 14/31 (45%), Positives = 19/31 (61%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCDV 197
C ++ +C+ L W CD D DC D SDE C +
Sbjct: 61 CRTSGLCVPLTWRCDRDLDCSDGSDEEECRI 91
>AF495471-1|AAM03232.1| 575|Homo sapiens thrombomodulin protein.
Length = 575
Score = 69.7 bits (163), Expect = 9e-11
Identities = 34/92 (36%), Positives = 43/92 (46%), Gaps = 7/92 (7%)
Query: 418 CPRGD----DEERCPLKRKCSAEEKCEKLCITTYD--GHAACACPMGFLLAEDKYSCRDI 471
CP G D C S + CE C+ D G +C C G+ LA D++ C D+
Sbjct: 267 CPAGAALQADGRSCTASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDV 326
Query: 472 DECMYEQDPVCSQTCSNTVGSFRCGCMTGYIL 503
D+C+ E P C Q C NT G F C C Y L
Sbjct: 327 DDCILEPSP-CPQRCVNTQGGFECHCYPNYDL 357
Score = 52.4 bits (120), Expect = 1e-05
Identities = 60/224 (26%), Positives = 94/224 (41%), Gaps = 30/224 (13%)
Query: 294 EDSCPMVPGS----CNAGEFKCNDGK-CIPERWRCDN---ERDCADGGDE---LNCKPNS 342
E +C +PG+ C AG DG+ C + N E C D+ +C +
Sbjct: 253 EHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCVPNPDQPGSYSCMCET 312
Query: 343 IRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTC-RPQEHLM-S 399
+ D++ C D C+L+ C T G E +C + + C P + +
Sbjct: 313 GYRLAADQHRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDGECVEPVDPCFRA 372
Query: 400 NAFRNC--VNR-KHVC---DGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAAC 453
N C +N+ ++C +G P + RC + C+ + C C + A+C
Sbjct: 373 NCEYQCQPLNQTSYLCVCAEGFAPIPH--EPHRCQMF--CN-QTACPADCDP--NTQASC 425
Query: 454 ACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGC 497
CP G++L +D + C DIDEC E CS C N G+F C C
Sbjct: 426 ECPEGYIL-DDGFICTDIDEC--ENGGFCSGVCHNLPGTFECIC 466
Score = 47.2 bits (107), Expect = 5e-04
Identities = 17/36 (47%), Positives = 19/36 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C NGGC H C PG C CP G L DG++C
Sbjct: 245 CSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSC 280
Score = 43.2 bits (97), Expect = 0.009
Identities = 30/105 (28%), Positives = 38/105 (36%), Gaps = 7/105 (6%)
Query: 411 VCDGMKDCPRGDDEERCPLKRKCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCR 469
+C +G P CS E CE C G C CP G L D SC
Sbjct: 223 MCTAPPGAVQGHWAREAPGAWDCSVENGGCEHAC-NAIPGAPRCQCPAGAALQADGRSCT 281
Query: 470 DIDECMYEQDPVCSQTC---SNTVGSFRCGCMTGYILRPDERSCK 511
+ +C C + GS+ C C TGY L D+ C+
Sbjct: 282 A--SATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCE 324
Score = 38.7 bits (86), Expect = 0.19
Identities = 17/53 (32%), Positives = 22/53 (41%), Gaps = 3/53 (5%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTGMPFE---KSTTDQTPKKCKSHPEEFLI 1371
C +NGGC H C P C CP G + +S T + C E F +
Sbjct: 245 CSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCV 297
>AF161254-1|AAF61850.1| 282|Homo sapiens 8D6 antigen protein.
Length = 282
Score = 69.7 bits (163), Expect = 9e-11
Identities = 48/148 (32%), Positives = 67/148 (45%), Gaps = 12/148 (8%)
Query: 263 CAEIDFECKNTK-CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERW 321
C F+C+ + CVP ++CD D DC D +DE+ C + P C + +C +P
Sbjct: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEP--CTQ-KGQCPPPPGLP--C 108
Query: 322 RCDNERDCADGGDELNCKPNSIRNCSLDEYTCA-DRRCVLKTWLCDGVRDCTNGEDEMNC 380
C DC+ GG + + S C E C C+ TW CDG DC + DE+ C
Sbjct: 109 PCTGVSDCS-GGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGC 167
Query: 381 ---EVSCEEDQYTCRPQEHLMS-NAFRN 404
E+ E D T P L S + RN
Sbjct: 168 GTNEILPEGDATTMGPPVTLESVTSLRN 195
Score = 68.9 bits (161), Expect = 2e-10
Identities = 43/130 (33%), Positives = 60/130 (46%), Gaps = 18/130 (13%)
Query: 302 GSCNAGEFKCN-DGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVL 360
GSC +F+C G C+P WRCD + DC+DG DE C+ I C+ + C +
Sbjct: 52 GSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECR---IEPCT-QKGQCPPPPGL- 106
Query: 361 KTWLCDGVRDCTNGEDE--MNC-EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKD 417
C GV DC+ G D+ NC ++C + C + +C+ CDG D
Sbjct: 107 -PCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSD--------DCIPLTWRCDGHPD 157
Query: 418 CPRGDDEERC 427
CP DE C
Sbjct: 158 CPDSSDELGC 167
Score = 41.9 bits (94), Expect = 0.020
Identities = 21/56 (37%), Positives = 32/56 (57%), Gaps = 4/56 (7%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCDVVKTSLLVPSANASLNIGDVITNPTV 222
C ++ CI L W CDG DC D SDE+ C T+ ++P +A+ +G +T +V
Sbjct: 139 CTLSDDCIPLTWRCDGHPDCPDSSDELGCG---TNEILPEGDAT-TMGPPVTLESV 190
Score = 40.7 bits (91), Expect = 0.046
Identities = 14/31 (45%), Positives = 19/31 (61%)
Query: 167 CHSTNVCIALEWLCDGDNDCGDFSDEINCDV 197
C ++ +C+ L W CD D DC D SDE C +
Sbjct: 61 CRTSGLCVPLTWRCDRDLDCSDGSDEEECRI 91
>AB209865-1|BAD93102.1| 1700|Homo sapiens latent transforming growth
factor beta binding protein 2 variant protein.
Length = 1700
Score = 69.7 bits (163), Expect = 9e-11
Identities = 69/252 (27%), Positives = 95/252 (37%), Gaps = 25/252 (9%)
Query: 270 CKNTKCVPKD--FQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPER--WRCDN 325
C + KC + F+C + +DE C V C A C G C+ + C
Sbjct: 899 CAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVD-EC-ASRASCPTGLCLNTEGSFACSA 956
Query: 326 ERDCADGG--DELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVS 383
C +G +E + C+ C C T +DC G S
Sbjct: 957 ---CENGYWVNEDGTACEDLDECAFPG-VCPSGVCT-NTAGSFSCKDCDGGYRPSPLGDS 1011
Query: 384 CEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEER---CPLKRKCSAEEKCE 440
CE+ PQ + +N V + C CP+G C +C EE C
Sbjct: 1012 CEDVDECEDPQSSCLGGECKNTVG-SYQCL----CPQGFQLANGTVCEDVNECMGEEHCA 1066
Query: 441 KL--CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCM 498
C+ ++ G C C GF+ AE SC+D+DEC DP C NT GSF C C
Sbjct: 1067 PHGECLNSH-GSFFCLCAPGFVSAEGGTSCQDVDECA-TTDPCVGGHCVNTEGSFNCLCE 1124
Query: 499 TGYILRPDERSC 510
TG+ P+ C
Sbjct: 1125 TGFQPSPESGEC 1136
Score = 61.7 bits (143), Expect = 2e-08
Identities = 70/262 (26%), Positives = 97/262 (37%), Gaps = 30/262 (11%)
Query: 270 CKNTKCV--PKDFQC----DG-DNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWR 322
C + +CV P + C +G G D + C + PG C G KC + + +R
Sbjct: 859 CPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNEC-LTPGVCAHG--KCTN---LEGSFR 912
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEV 382
C E+ DE C+ + C+ +C C L T C NG
Sbjct: 913 CSCEQGYEVTSDEKGCQ--DVDECA-SRASCPTGLC-LNTEGSFACSACENGYWVNEDGT 968
Query: 383 SCEEDQYTCRPQEHLMSNAFRNCVNRKHV--CDG-MKDCPRGD---DEERCPLKRKCSAE 436
+CE D C S N CDG + P GD D + C +
Sbjct: 969 ACE-DLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLG 1027
Query: 437 EKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCG 496
+C+ G C CP GF LA C D++ECM E+ C N+ GSF C
Sbjct: 1028 GECKNTV-----GSYQCLCPQGFQLANGTV-CEDVNECMGEEHCAPHGECLNSHGSFFCL 1081
Query: 497 CMTGYILRPDERSCKPTGESPT 518
C G++ SC+ E T
Sbjct: 1082 CAPGFVSAEGGTSCQDVDECAT 1103
Score = 59.3 bits (137), Expect = 1e-07
Identities = 65/244 (26%), Positives = 95/244 (38%), Gaps = 30/244 (12%)
Query: 270 CKNTKCVPKD-FQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERD 328
C+N V +D C+ ++C CP + AG F C D CD
Sbjct: 957 CENGYWVNEDGTACEDLDECAF---PGVCPSGVCTNTAGSFSCKD---------CDGGYR 1004
Query: 329 CADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQ 388
+ GD +C+ + C + +C C K + C G N V CE D
Sbjct: 1005 PSPLGD--SCE--DVDECEDPQSSCLGGEC--KNTVGSYQCLCPQGFQLANGTV-CE-DV 1056
Query: 389 YTCRPQEHLMSNAFRNCVNR--KHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEK-LCIT 445
C +EH + C+N C + C +C+ + C C+
Sbjct: 1057 NECMGEEHCAPHG--ECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVN 1114
Query: 446 TYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC-SQTCSNTVGSFRC--GCMTGYI 502
T +G C C GF + + C DIDEC DPVC + C N+ GS+RC GC G+
Sbjct: 1115 T-EGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFH 1173
Query: 503 LRPD 506
+ P+
Sbjct: 1174 MAPN 1177
Score = 52.0 bits (119), Expect = 2e-05
Identities = 63/243 (25%), Positives = 92/243 (37%), Gaps = 36/243 (14%)
Query: 293 DEDSCPMVPGSCNAGEF---------KCNDGKCIPERWRCDNERDCADGGD--ELNC--K 339
D + C PG C+ G+ +C+ G + + C + +C G + C
Sbjct: 809 DINECEQ-PGVCSGGQCTNTEGSYHCECDQGYIMVRKGHCQDINECRHPGTCPDGRCVNS 867
Query: 340 PNSIRNCSLDE-YTCADRRCV-LKTWLCDGV---RDCTNGEDEMNCEVSCEE------DQ 388
P S + +E Y CV + L GV CTN E C SCE+ D+
Sbjct: 868 PGSYTCLACEEGYRGQSGSCVDVNECLTPGVCAHGKCTNLEGSFRC--SCEQGYEVTSDE 925
Query: 389 YTCRPQEHLMSNAFRN---CVNRKHVCDGMKDCPRG----DDEERCPLKRKCSAEEKCEK 441
C+ + S A C+N + C G +D C +C+ C
Sbjct: 926 KGCQDVDECASRASCPTGLCLNTEGSF-ACSACENGYWVNEDGTACEDLDECAFPGVCPS 984
Query: 442 LCITTYDGHAACA-CPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTG 500
T G +C C G+ + SC D+DEC Q C NTVGS++C C G
Sbjct: 985 GVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQG 1044
Query: 501 YIL 503
+ L
Sbjct: 1045 FQL 1047
Score = 47.6 bits (108), Expect = 4e-04
Identities = 27/83 (32%), Positives = 37/83 (44%), Gaps = 5/83 (6%)
Query: 432 KCSAEEKCEK-LCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP--VCSQT-CS 487
+C CE C+ +G+ C C GF L +C D++EC P +C C
Sbjct: 1615 ECGILNGCENGRCVRVREGYT-CDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCE 1673
Query: 488 NTVGSFRCGCMTGYILRPDERSC 510
NT GS+RC C GY+ C
Sbjct: 1674 NTEGSYRCHCSPGYVAEAGPPHC 1696
Score = 46.8 bits (106), Expect = 7e-04
Identities = 29/104 (27%), Positives = 40/104 (38%), Gaps = 8/104 (7%)
Query: 414 GMKDCPRGD--DEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDI 471
G P GD D + C C + C+ DG C C GF ++ + C D+
Sbjct: 1171 GFHMAPNGDCIDIDECANDTMCGSHGFCDNT-----DGSFRCLCDQGFEISPSGWDCVDV 1225
Query: 472 DECMYEQDPVCSQTCSNTVGSFRCGCMTGY-ILRPDERSCKPTG 514
+EC + C N GSF C C + E C+P G
Sbjct: 1226 NECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRG 1269
Score = 46.4 bits (105), Expect = 0.001
Identities = 71/272 (26%), Positives = 100/272 (36%), Gaps = 47/272 (17%)
Query: 270 CKNTKCVPKDFQCDGD---NDCGD-WTDEDSCPMVPGSCNAGEFKCNDG--KCI-PERWR 322
C NT CDG + GD D D C SC GE K G +C+ P+ ++
Sbjct: 987 CTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQ 1046
Query: 323 CDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLK--TWLCDGVRDCTNGEDEMNC 380
N C D + C +E+ C+ ++ C C G
Sbjct: 1047 LANGTVCED-----------VNECMGEEHCAPHGECLNSHGSFFCL----CAPGFVSAEG 1091
Query: 381 EVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCE 440
SC+ D C + + +CVN +G +C + P +C ++CE
Sbjct: 1092 GTSCQ-DVDECATTDPCVGG---HCVNT----EGSFNCLCETGFQPSPESGECVDIDECE 1143
Query: 441 K----LCIT----TYDGHAACA--CPMGFLLAEDKYSCRDIDECMYEQDPVCSQT--CSN 488
+C T G C C GF +A + C DIDEC D +C C N
Sbjct: 1144 DYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNG-DCIDIDECA--NDTMCGSHGFCDN 1200
Query: 489 TVGSFRCGCMTGYILRPDERSCKPTGESPTLL 520
T GSFRC C G+ + P C E +L
Sbjct: 1201 TDGSFRCLCDQGFEISPSGWDCVDVNECELML 1232
Score = 45.2 bits (102), Expect = 0.002
Identities = 30/95 (31%), Positives = 37/95 (38%), Gaps = 5/95 (5%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGY 501
C+ T G+ C C GF C D DEC QD C C NT GSF C C
Sbjct: 1381 CLNTVPGYV-CLCNPGFHYDASHKKCEDHDEC---QDLACENGECVNTEGSFHCFCSPPL 1436
Query: 502 ILRPDERSCKPTGESPTLLFSNRIGIRQVWLTGDN 536
L ++ C + S L + I + W N
Sbjct: 1437 TLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKATN 1471
Score = 44.8 bits (101), Expect = 0.003
Identities = 23/62 (37%), Positives = 32/62 (51%), Gaps = 4/62 (6%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGY 501
C+ DG+ C C G+ L + C D +EC+ +DP + C N VGS+ C C GY
Sbjct: 740 CVNLPDGYR-CVCSPGYQLHPSQAYCTDDNECL--RDPCKGKGRCINRVGSYSCFCYPGY 796
Query: 502 IL 503
L
Sbjct: 797 TL 798
Score = 41.1 bits (92), Expect = 0.035
Identities = 28/96 (29%), Positives = 39/96 (40%), Gaps = 7/96 (7%)
Query: 425 ERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ 484
+ C +C C T +G C C G+++ K C+DI+EC + C
Sbjct: 805 QECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVR-KGHCQDINECRH--PGTCPD 861
Query: 485 -TCSNTVGSFRC-GCMTGYILRPDERSCKPTGESPT 518
C N+ GS+ C C GY R SC E T
Sbjct: 862 GRCVNSPGSYTCLACEEGY--RGQSGSCVDVNECLT 895
Score = 37.9 bits (84), Expect = 0.33
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 4/57 (7%)
Query: 455 CPMGFLLAEDKYSCRDIDECMYEQDPVCSQT-CSNTVGSFRCGCMTGYILRPDERSC 510
CP G+ + C+DI+EC+ +C C NT GS+ C C G +L P C
Sbjct: 487 CPQGYKRLNLTH-CQDINECLTLG--LCKDAECVNTRGSYLCTCRPGLMLDPSRSRC 540
Score = 35.1 bits (77), Expect = 2.3
Identities = 17/46 (36%), Positives = 19/46 (41%), Gaps = 1/46 (2%)
Query: 471 IDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
ID C VC TC N +RC C GY L P + C E
Sbjct: 724 IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNE 769
>M34057-1|AAA61160.1| 1394|Homo sapiens TGFB1 protein.
Length = 1394
Score = 69.3 bits (162), Expect = 1e-10
Identities = 76/281 (27%), Positives = 103/281 (36%), Gaps = 36/281 (12%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDC--GDWTDEDSCPMVPGSCNAGEFKCNDGKCIPER 320
C E F N +C+ D +C N C GD ++ + M SC+ G + D K +
Sbjct: 698 CTE-GFRGWNGQCLDVD-ECLEPNVCANGDCSNLEGSYMC--SCHKGYTRTPDHKHCRDI 753
Query: 321 WRCDNERDCADGG-----DELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGE 375
C C +G C S + C D LC C N E
Sbjct: 754 DECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLC-AHGQCRNTE 812
Query: 376 DEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCD--------GMKDC--PRG---D 422
C C++ +H C+ K VC G DC P G D
Sbjct: 813 GSFQCV--CDQGYRASGLGDHCED--INECLEDKSVCQRGDCINTAGSYDCTCPDGFQLD 868
Query: 423 DEERCPLKRKCSAEEKC--EKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP 480
D + C +C C + C+ T +G C C GF ++ D +C DIDEC+ +
Sbjct: 869 DNKTCQDINECEHPGLCGPQGECLNT-EGSFHCVCQQGFSISADGRTCEDIDECV--NNT 925
Query: 481 VCSQ--TCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTL 519
VC C NT GSFRC C G+ D + C E L
Sbjct: 926 VCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELL 966
Score = 64.1 bits (149), Expect = 4e-09
Identities = 78/275 (28%), Positives = 112/275 (40%), Gaps = 43/275 (15%)
Query: 262 RCAEIDFECKNTKCVPKDFQC---DGDNDC-----------GDWTDEDSCPMVPGSCNAG 307
RC +ID EC N P D QC G C G D D C + P C G
Sbjct: 668 RCEDID-ECLNPSTCP-DEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDEC-LEPNVCANG 724
Query: 308 EFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDG 367
+ +G + C + D +C+ I C C + +C K +G
Sbjct: 725 DCSNLEGS-----YMCSCHKGYTRTPDHKHCR--DIDECQQGNL-CVNGQC--KN--TEG 772
Query: 368 VRDCTNGED-EMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNR-KHVCD-GMKDCPRGDDE 424
CT G+ +++ ED C+ + RN + VCD G + GD
Sbjct: 773 SFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGD-- 830
Query: 425 ERCPLKRKCSAEEK-CEKL-CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC 482
C +C ++ C++ CI T G C CP GF L ++K +C+DI+EC E +C
Sbjct: 831 -HCEDINECLEDKSVCQRGDCINTA-GSYDCTCPDGFQLDDNK-TCQDINEC--EHPGLC 885
Query: 483 SQT--CSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C NT GSF C C G+ + D R+C+ E
Sbjct: 886 GPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDE 920
Score = 60.9 bits (141), Expect = 4e-08
Identities = 62/267 (23%), Positives = 105/267 (39%), Gaps = 26/267 (9%)
Query: 258 VELMRCAEIDFECKNTKCVPK--DFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK 315
+++ C D C CV F+C+ + T C + N C D +
Sbjct: 629 IDVDECLRPDV-CGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPST--CPDEQ 685
Query: 316 CI--PERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRC--VLKTWLCDGVRDC 371
C+ P ++C C +G N + + C L+ CA+ C + +++C +
Sbjct: 686 CVNSPGSYQCV---PCTEGFRGWNGQCLDVDEC-LEPNVCANGDCSNLEGSYMCSCHKGY 741
Query: 372 TNGEDEMNCEV--SCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPL 429
T D +C C++ Q +FR + + KD + +D + C
Sbjct: 742 TRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKD--QCEDIDECQH 799
Query: 430 KRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSN 488
+ C A +C +G C C G+ + C DI+EC+ E VC + C N
Sbjct: 800 RHLC-AHGQCRNT-----EGSFQCVCDQGYRASGLGDHCEDINECL-EDKSVCQRGDCIN 852
Query: 489 TVGSFRCGCMTGYILRPDERSCKPTGE 515
T GS+ C C G+ L D ++C+ E
Sbjct: 853 TAGSYDCTCPDGFQL-DDNKTCQDINE 878
Score = 57.2 bits (132), Expect = 5e-07
Identities = 31/103 (30%), Positives = 54/103 (52%), Gaps = 7/103 (6%)
Query: 404 NCVNR--KHVCDGMKDCPRGDDEERCPLKRKCS-AEEKCEKLCITTYDGHAACACPMGFL 460
+C+N ++ C + + + +C +C+ + C + +G C CP GF+
Sbjct: 561 HCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFM 620
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCG-CMTGY 501
+E+ +C D+DEC+ + VC + C NTVG+FRC C +GY
Sbjct: 621 ASEEGTNCIDVDECL--RPDVCGEGHCVNTVGAFRCEYCDSGY 661
Score = 50.8 bits (116), Expect = 4e-05
Identities = 24/59 (40%), Positives = 32/59 (54%), Gaps = 2/59 (3%)
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGYILRPDERSC 510
C C G+ +E + C DIDEC Q +CSQ C NT GSF C C G++ + +C
Sbjct: 571 CICYEGYRFSEQQRKCVDIDECTQVQH-LCSQGRCENTEGSFLCICPAGFMASEEGTNC 628
Score = 50.0 bits (114), Expect = 8e-05
Identities = 26/85 (30%), Positives = 41/85 (48%), Gaps = 5/85 (5%)
Query: 432 KCSAEEKCEK-LCITTYDGHAACACPMGFLLAEDKYSCRDIDEC--MYEQDPVCSQT-CS 487
+C CE C+ +G+ C C G+ L K +C D++EC + + +C C
Sbjct: 1297 ECGILNGCENGRCVRVQEGYT-CDCLDGYHLDTAKMTCFDVNECDELNNRMSLCKNAKCI 1355
Query: 488 NTVGSFRCGCMTGYILRPDERSCKP 512
NT GS++C C+ GY+ C P
Sbjct: 1356 NTDGSYKCLCLPGYVPSDKPNYCTP 1380
Score = 47.2 bits (107), Expect = 5e-04
Identities = 27/82 (32%), Positives = 36/82 (43%), Gaps = 3/82 (3%)
Query: 436 EEKCEK-LCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFR 494
+E C+ C+ T G+ C C G K C D+DEC + Q C NT GS+
Sbjct: 1106 QEICKNGFCLNTRPGYE-CYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQ-CVNTEGSYN 1163
Query: 495 CGCMTGYILRPDERSCKPTGES 516
C C +L E+ C ES
Sbjct: 1164 CFCTHPMVLDASEKRCIRPAES 1185
Score = 46.8 bits (106), Expect = 7e-04
Identities = 58/240 (24%), Positives = 89/240 (37%), Gaps = 24/240 (10%)
Query: 266 IDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKC--IPERWRC 323
++ +CKNT+ F+C +D C + C C G+C ++C
Sbjct: 763 VNGQCKNTE---GSFRCTCGQGYQLSAAKDQCEDID-ECQHRHL-CAHGQCRNTEGSFQC 817
Query: 324 DNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNG---EDEMNC 380
++ G +C+ I C D+ C C+ D C +G +D C
Sbjct: 818 VCDQGYRASGLGDHCE--DINECLEDKSVCQRGDCINTAGSYDCT--CPDGFQLDDNKTC 873
Query: 381 EVSCE-EDQYTCRPQ-EHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEK 438
+ E E C PQ E L + +CV ++ D +D + C C +
Sbjct: 874 QDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISA-DGRTCEDIDECVNNTVCDSHGF 932
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQT-CSNTVGSFRCGC 497
C+ G C C GF +D C D++EC VC + C N GSF C C
Sbjct: 933 CDNTA-----GSFRCLCYQGFQAPQDGQGCVDVNECELLSG-VCGEAFCENVEGSFLCVC 986
Score = 43.2 bits (97), Expect = 0.009
Identities = 27/78 (34%), Positives = 39/78 (50%), Gaps = 7/78 (8%)
Query: 437 EKCEKLCITTYDGH-AACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFR 494
+KC K +Y G+ C G+ + + C+DI+EC + VC C NT+GS+R
Sbjct: 269 QKCPKK--PSYHGYNQMMECLPGYKRVNNTF-CQDINECQLQG--VCPNGECLNTMGSYR 323
Query: 495 CGCMTGYILRPDERSCKP 512
C C G+ P SC P
Sbjct: 324 CTCKIGFGPDPTFSSCVP 341
>BC130289-1|AAI30290.1| 1395|Homo sapiens latent transforming growth
factor beta binding protein 1 protein.
Length = 1395
Score = 69.3 bits (162), Expect = 1e-10
Identities = 76/281 (27%), Positives = 103/281 (36%), Gaps = 36/281 (12%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDC--GDWTDEDSCPMVPGSCNAGEFKCNDGKCIPER 320
C E F N +C+ D +C N C GD ++ + M SC+ G + D K +
Sbjct: 699 CTE-GFRGWNGQCLDVD-ECLEPNVCANGDCSNLEGSYMC--SCHKGYTRTPDHKHCRDI 754
Query: 321 WRCDNERDCADGG-----DELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGE 375
C C +G C S + C D LC C N E
Sbjct: 755 DECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLC-AHGQCRNTE 813
Query: 376 DEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCD--------GMKDC--PRG---D 422
C C++ +H C+ K VC G DC P G D
Sbjct: 814 GSFQCV--CDQGYRASGLGDHCED--INECLEDKSVCQRGDCINTAGSYDCTCPDGFQLD 869
Query: 423 DEERCPLKRKCSAEEKC--EKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP 480
D + C +C C + C+ T +G C C GF ++ D +C DIDEC+ +
Sbjct: 870 DNKTCQDINECEHPGLCGPQGECLNT-EGSFHCVCQQGFSISADGRTCEDIDECV--NNT 926
Query: 481 VCSQ--TCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTL 519
VC C NT GSFRC C G+ D + C E L
Sbjct: 927 VCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELL 967
Score = 64.1 bits (149), Expect = 4e-09
Identities = 78/275 (28%), Positives = 112/275 (40%), Gaps = 43/275 (15%)
Query: 262 RCAEIDFECKNTKCVPKDFQC---DGDNDC-----------GDWTDEDSCPMVPGSCNAG 307
RC +ID EC N P D QC G C G D D C + P C G
Sbjct: 669 RCEDID-ECLNPSTCP-DEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDEC-LEPNVCANG 725
Query: 308 EFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDG 367
+ +G + C + D +C+ I C C + +C K +G
Sbjct: 726 DCSNLEGS-----YMCSCHKGYTRTPDHKHCR--DIDECQQGNL-CVNGQC--KN--TEG 773
Query: 368 VRDCTNGED-EMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNR-KHVCD-GMKDCPRGDDE 424
CT G+ +++ ED C+ + RN + VCD G + GD
Sbjct: 774 SFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGD-- 831
Query: 425 ERCPLKRKCSAEEK-CEKL-CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC 482
C +C ++ C++ CI T G C CP GF L ++K +C+DI+EC E +C
Sbjct: 832 -HCEDINECLEDKSVCQRGDCINTA-GSYDCTCPDGFQLDDNK-TCQDINEC--EHPGLC 886
Query: 483 SQT--CSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C NT GSF C C G+ + D R+C+ E
Sbjct: 887 GPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDE 921
Score = 60.9 bits (141), Expect = 4e-08
Identities = 62/267 (23%), Positives = 105/267 (39%), Gaps = 26/267 (9%)
Query: 258 VELMRCAEIDFECKNTKCVPK--DFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK 315
+++ C D C CV F+C+ + T C + N C D +
Sbjct: 630 IDVDECLRPDV-CGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPST--CPDEQ 686
Query: 316 CI--PERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRC--VLKTWLCDGVRDC 371
C+ P ++C C +G N + + C L+ CA+ C + +++C +
Sbjct: 687 CVNSPGSYQCV---PCTEGFRGWNGQCLDVDEC-LEPNVCANGDCSNLEGSYMCSCHKGY 742
Query: 372 TNGEDEMNCEV--SCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPL 429
T D +C C++ Q +FR + + KD + +D + C
Sbjct: 743 TRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKD--QCEDIDECQH 800
Query: 430 KRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSN 488
+ C A +C +G C C G+ + C DI+EC+ E VC + C N
Sbjct: 801 RHLC-AHGQCRNT-----EGSFQCVCDQGYRASGLGDHCEDINECL-EDKSVCQRGDCIN 853
Query: 489 TVGSFRCGCMTGYILRPDERSCKPTGE 515
T GS+ C C G+ L D ++C+ E
Sbjct: 854 TAGSYDCTCPDGFQL-DDNKTCQDINE 879
Score = 57.2 bits (132), Expect = 5e-07
Identities = 31/103 (30%), Positives = 54/103 (52%), Gaps = 7/103 (6%)
Query: 404 NCVNR--KHVCDGMKDCPRGDDEERCPLKRKCS-AEEKCEKLCITTYDGHAACACPMGFL 460
+C+N ++ C + + + +C +C+ + C + +G C CP GF+
Sbjct: 562 HCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFM 621
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCG-CMTGY 501
+E+ +C D+DEC+ + VC + C NTVG+FRC C +GY
Sbjct: 622 ASEEGTNCIDVDECL--RPDVCGEGHCVNTVGAFRCEYCDSGY 662
Score = 50.8 bits (116), Expect = 4e-05
Identities = 24/59 (40%), Positives = 32/59 (54%), Gaps = 2/59 (3%)
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGYILRPDERSC 510
C C G+ +E + C DIDEC Q +CSQ C NT GSF C C G++ + +C
Sbjct: 572 CICYEGYRFSEQQRKCVDIDECTQVQH-LCSQGRCENTEGSFLCICPAGFMASEEGTNC 629
Score = 49.6 bits (113), Expect = 1e-04
Identities = 26/85 (30%), Positives = 41/85 (48%), Gaps = 5/85 (5%)
Query: 432 KCSAEEKCEK-LCITTYDGHAACACPMGFLLAEDKYSCRDIDEC--MYEQDPVCSQT-CS 487
+C CE C+ +G+ C C G+ L K +C D++EC + + +C C
Sbjct: 1298 ECGILNGCENGRCVRVQEGYT-CDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCI 1356
Query: 488 NTVGSFRCGCMTGYILRPDERSCKP 512
NT GS++C C+ GY+ C P
Sbjct: 1357 NTDGSYKCLCLPGYVPSDKPNYCTP 1381
Score = 47.2 bits (107), Expect = 5e-04
Identities = 27/82 (32%), Positives = 36/82 (43%), Gaps = 3/82 (3%)
Query: 436 EEKCEK-LCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFR 494
+E C+ C+ T G+ C C G K C D+DEC + Q C NT GS+
Sbjct: 1107 QEICKNGFCLNTRPGYE-CYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQ-CVNTEGSYN 1164
Query: 495 CGCMTGYILRPDERSCKPTGES 516
C C +L E+ C ES
Sbjct: 1165 CFCTHPMVLDASEKRCIRPAES 1186
Score = 46.8 bits (106), Expect = 7e-04
Identities = 58/240 (24%), Positives = 89/240 (37%), Gaps = 24/240 (10%)
Query: 266 IDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKC--IPERWRC 323
++ +CKNT+ F+C +D C + C C G+C ++C
Sbjct: 764 VNGQCKNTE---GSFRCTCGQGYQLSAAKDQCEDID-ECQHRHL-CAHGQCRNTEGSFQC 818
Query: 324 DNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNG---EDEMNC 380
++ G +C+ I C D+ C C+ D C +G +D C
Sbjct: 819 VCDQGYRASGLGDHCE--DINECLEDKSVCQRGDCINTAGSYDCT--CPDGFQLDDNKTC 874
Query: 381 EVSCE-EDQYTCRPQ-EHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEK 438
+ E E C PQ E L + +CV ++ D +D + C C +
Sbjct: 875 QDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISA-DGRTCEDIDECVNNTVCDSHGF 933
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQT-CSNTVGSFRCGC 497
C+ G C C GF +D C D++EC VC + C N GSF C C
Sbjct: 934 CDNTA-----GSFRCLCYQGFQAPQDGQGCVDVNECELLSG-VCGEAFCENVEGSFLCVC 987
Score = 43.2 bits (97), Expect = 0.009
Identities = 27/78 (34%), Positives = 39/78 (50%), Gaps = 7/78 (8%)
Query: 437 EKCEKLCITTYDGH-AACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFR 494
+KC K +Y G+ C G+ + + C+DI+EC + VC C NT+GS+R
Sbjct: 269 QKCPKK--PSYHGYNQMMECLPGYKRVNNTF-CQDINECQLQG--VCPNGECLNTMGSYR 323
Query: 495 CGCMTGYILRPDERSCKP 512
C C G+ P SC P
Sbjct: 324 CTCKIGFGPDPTFSSCVP 341
>AF489528-1|AAM03124.1| 1394|Homo sapiens transforming growth
factor-beta binding protein-1S protein.
Length = 1394
Score = 69.3 bits (162), Expect = 1e-10
Identities = 76/281 (27%), Positives = 103/281 (36%), Gaps = 36/281 (12%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDC--GDWTDEDSCPMVPGSCNAGEFKCNDGKCIPER 320
C E F N +C+ D +C N C GD ++ + M SC+ G + D K +
Sbjct: 698 CTE-GFRGWNGQCLDVD-ECLEPNVCANGDCSNLEGSYMC--SCHKGYTRTPDHKHCRDI 753
Query: 321 WRCDNERDCADGG-----DELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGE 375
C C +G C S + C D LC C N E
Sbjct: 754 DECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLC-AHGQCRNTE 812
Query: 376 DEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCD--------GMKDC--PRG---D 422
C C++ +H C+ K VC G DC P G D
Sbjct: 813 GSFQCV--CDQGYRASGLGDHCED--INECLEDKSVCQRGDCINTAGSYDCTCPDGFQLD 868
Query: 423 DEERCPLKRKCSAEEKC--EKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP 480
D + C +C C + C+ T +G C C GF ++ D +C DIDEC+ +
Sbjct: 869 DNKTCQDINECEHPGLCGPQGECLNT-EGSFHCVCQQGFSISADGRTCEDIDECV--NNT 925
Query: 481 VCSQ--TCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTL 519
VC C NT GSFRC C G+ D + C E L
Sbjct: 926 VCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELL 966
Score = 64.1 bits (149), Expect = 4e-09
Identities = 78/275 (28%), Positives = 112/275 (40%), Gaps = 43/275 (15%)
Query: 262 RCAEIDFECKNTKCVPKDFQC---DGDNDC-----------GDWTDEDSCPMVPGSCNAG 307
RC +ID EC N P D QC G C G D D C + P C G
Sbjct: 668 RCEDID-ECLNPSTCP-DEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDEC-LEPNVCANG 724
Query: 308 EFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDG 367
+ +G + C + D +C+ I C C + +C K +G
Sbjct: 725 DCSNLEGS-----YMCSCHKGYTRTPDHKHCR--DIDECQQGNL-CVNGQC--KN--TEG 772
Query: 368 VRDCTNGED-EMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNR-KHVCD-GMKDCPRGDDE 424
CT G+ +++ ED C+ + RN + VCD G + GD
Sbjct: 773 SFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGD-- 830
Query: 425 ERCPLKRKCSAEEK-CEKL-CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC 482
C +C ++ C++ CI T G C CP GF L ++K +C+DI+EC E +C
Sbjct: 831 -HCEDINECLEDKSVCQRGDCINTA-GSYDCTCPDGFQLDDNK-TCQDINEC--EHPGLC 885
Query: 483 SQT--CSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C NT GSF C C G+ + D R+C+ E
Sbjct: 886 GPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDE 920
Score = 60.9 bits (141), Expect = 4e-08
Identities = 62/267 (23%), Positives = 105/267 (39%), Gaps = 26/267 (9%)
Query: 258 VELMRCAEIDFECKNTKCVPK--DFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK 315
+++ C D C CV F+C+ + T C + N C D +
Sbjct: 629 IDVDECLRPDV-CGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPST--CPDEQ 685
Query: 316 CI--PERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRC--VLKTWLCDGVRDC 371
C+ P ++C C +G N + + C L+ CA+ C + +++C +
Sbjct: 686 CVNSPGSYQCV---PCTEGFRGWNGQCLDVDEC-LEPNVCANGDCSNLEGSYMCSCHKGY 741
Query: 372 TNGEDEMNCEV--SCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPL 429
T D +C C++ Q +FR + + KD + +D + C
Sbjct: 742 TRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKD--QCEDIDECQH 799
Query: 430 KRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSN 488
+ C A +C +G C C G+ + C DI+EC+ E VC + C N
Sbjct: 800 RHLC-AHGQCRNT-----EGSFQCVCDQGYRASGLGDHCEDINECL-EDKSVCQRGDCIN 852
Query: 489 TVGSFRCGCMTGYILRPDERSCKPTGE 515
T GS+ C C G+ L D ++C+ E
Sbjct: 853 TAGSYDCTCPDGFQL-DDNKTCQDINE 878
Score = 57.2 bits (132), Expect = 5e-07
Identities = 31/103 (30%), Positives = 54/103 (52%), Gaps = 7/103 (6%)
Query: 404 NCVNR--KHVCDGMKDCPRGDDEERCPLKRKCS-AEEKCEKLCITTYDGHAACACPMGFL 460
+C+N ++ C + + + +C +C+ + C + +G C CP GF+
Sbjct: 561 HCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFM 620
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCG-CMTGY 501
+E+ +C D+DEC+ + VC + C NTVG+FRC C +GY
Sbjct: 621 ASEEGTNCIDVDECL--RPDVCGEGHCVNTVGAFRCEYCDSGY 661
Score = 50.8 bits (116), Expect = 4e-05
Identities = 24/59 (40%), Positives = 32/59 (54%), Gaps = 2/59 (3%)
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGYILRPDERSC 510
C C G+ +E + C DIDEC Q +CSQ C NT GSF C C G++ + +C
Sbjct: 571 CICYEGYRFSEQQRKCVDIDECTQVQH-LCSQGRCENTEGSFLCICPAGFMASEEGTNC 628
Score = 50.0 bits (114), Expect = 8e-05
Identities = 26/85 (30%), Positives = 41/85 (48%), Gaps = 5/85 (5%)
Query: 432 KCSAEEKCEK-LCITTYDGHAACACPMGFLLAEDKYSCRDIDEC--MYEQDPVCSQT-CS 487
+C CE C+ +G+ C C G+ L K +C D++EC + + +C C
Sbjct: 1297 ECGILNGCENGRCVRVQEGYT-CDCLDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCI 1355
Query: 488 NTVGSFRCGCMTGYILRPDERSCKP 512
NT GS++C C+ GY+ C P
Sbjct: 1356 NTDGSYKCLCLPGYVPSDKPNYCTP 1380
Score = 47.2 bits (107), Expect = 5e-04
Identities = 27/82 (32%), Positives = 36/82 (43%), Gaps = 3/82 (3%)
Query: 436 EEKCEK-LCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFR 494
+E C+ C+ T G+ C C G K C D+DEC + Q C NT GS+
Sbjct: 1106 QEICKNGFCLNTRPGYE-CYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQ-CVNTEGSYN 1163
Query: 495 CGCMTGYILRPDERSCKPTGES 516
C C +L E+ C ES
Sbjct: 1164 CFCTHPMVLDASEKRCIRPAES 1185
Score = 46.8 bits (106), Expect = 7e-04
Identities = 58/240 (24%), Positives = 89/240 (37%), Gaps = 24/240 (10%)
Query: 266 IDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKC--IPERWRC 323
++ +CKNT+ F+C +D C + C C G+C ++C
Sbjct: 763 VNGQCKNTE---GSFRCTCGQGYQLSAAKDQCEDID-ECQHRHL-CAHGQCRNTEGSFQC 817
Query: 324 DNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNG---EDEMNC 380
++ G +C+ I C D+ C C+ D C +G +D C
Sbjct: 818 VCDQGYRASGLGDHCE--DINECLEDKSVCQRGDCINTAGSYDCT--CPDGFQLDDNKTC 873
Query: 381 EVSCE-EDQYTCRPQ-EHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEK 438
+ E E C PQ E L + +CV ++ D +D + C C +
Sbjct: 874 QDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISA-DGRTCEDIDECVNNTVCDSHGF 932
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQT-CSNTVGSFRCGC 497
C+ G C C GF +D C D++EC VC + C N GSF C C
Sbjct: 933 CDNTA-----GSFRCLCYQGFQAPQDGQGCVDVNECELLSG-VCGEAFCENVEGSFLCVC 986
Score = 43.2 bits (97), Expect = 0.009
Identities = 27/78 (34%), Positives = 39/78 (50%), Gaps = 7/78 (8%)
Query: 437 EKCEKLCITTYDGH-AACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFR 494
+KC K +Y G+ C G+ + + C+DI+EC + VC C NT+GS+R
Sbjct: 269 QKCPKK--PSYHGYNQMMECLPGYKRVNNTF-CQDINECQLQG--VCPNGECLNTMGSYR 323
Query: 495 CGCMTGYILRPDERSCKP 512
C C G+ P SC P
Sbjct: 324 CTCKIGFGPDPTFSSCVP 341
>AC019127-1|AAY24260.1| 697|Homo sapiens unknown protein.
Length = 697
Score = 69.3 bits (162), Expect = 1e-10
Identities = 76/281 (27%), Positives = 103/281 (36%), Gaps = 36/281 (12%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDC--GDWTDEDSCPMVPGSCNAGEFKCNDGKCIPER 320
C E F N +C+ D +C N C GD ++ + M SC+ G + D K +
Sbjct: 152 CTE-GFRGWNGQCLDVD-ECLEPNVCANGDCSNLEGSYMC--SCHKGYTRTPDHKHCRDI 207
Query: 321 WRCDNERDCADGG-----DELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGE 375
C C +G C S + C D LC C N E
Sbjct: 208 DECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLC-AHGQCRNTE 266
Query: 376 DEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCD--------GMKDC--PRG---D 422
C C++ +H C+ K VC G DC P G D
Sbjct: 267 GSFQCV--CDQGYRASGLGDHCED--INECLEDKSVCQRGDCINTAGSYDCTCPDGFQLD 322
Query: 423 DEERCPLKRKCSAEEKC--EKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP 480
D + C +C C + C+ T +G C C GF ++ D +C DIDEC+ +
Sbjct: 323 DNKTCQDINECEHPGLCGPQGECLNT-EGSFHCVCQQGFSISADGRTCEDIDECV--NNT 379
Query: 481 VCSQ--TCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTL 519
VC C NT GSFRC C G+ D + C E L
Sbjct: 380 VCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELL 420
Score = 64.1 bits (149), Expect = 4e-09
Identities = 78/275 (28%), Positives = 112/275 (40%), Gaps = 43/275 (15%)
Query: 262 RCAEIDFECKNTKCVPKDFQC---DGDNDC-----------GDWTDEDSCPMVPGSCNAG 307
RC +ID EC N P D QC G C G D D C + P C G
Sbjct: 122 RCEDID-ECLNPSTCP-DEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDEC-LEPNVCANG 178
Query: 308 EFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDG 367
+ +G + C + D +C+ I C C + +C K +G
Sbjct: 179 DCSNLEGS-----YMCSCHKGYTRTPDHKHCR--DIDECQQGNL-CVNGQC--KN--TEG 226
Query: 368 VRDCTNGED-EMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNR-KHVCD-GMKDCPRGDDE 424
CT G+ +++ ED C+ + RN + VCD G + GD
Sbjct: 227 SFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGD-- 284
Query: 425 ERCPLKRKCSAEEK-CEKL-CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC 482
C +C ++ C++ CI T G C CP GF L ++K +C+DI+EC E +C
Sbjct: 285 -HCEDINECLEDKSVCQRGDCINTA-GSYDCTCPDGFQLDDNK-TCQDINEC--EHPGLC 339
Query: 483 SQT--CSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C NT GSF C C G+ + D R+C+ E
Sbjct: 340 GPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDE 374
Score = 60.9 bits (141), Expect = 4e-08
Identities = 62/267 (23%), Positives = 105/267 (39%), Gaps = 26/267 (9%)
Query: 258 VELMRCAEIDFECKNTKCVPK--DFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK 315
+++ C D C CV F+C+ + T C + N C D +
Sbjct: 83 IDVDECLRPDV-CGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPST--CPDEQ 139
Query: 316 CI--PERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRC--VLKTWLCDGVRDC 371
C+ P ++C C +G N + + C L+ CA+ C + +++C +
Sbjct: 140 CVNSPGSYQCV---PCTEGFRGWNGQCLDVDEC-LEPNVCANGDCSNLEGSYMCSCHKGY 195
Query: 372 TNGEDEMNCEV--SCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPL 429
T D +C C++ Q +FR + + KD + +D + C
Sbjct: 196 TRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKD--QCEDIDECQH 253
Query: 430 KRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSN 488
+ C A +C +G C C G+ + C DI+EC+ E VC + C N
Sbjct: 254 RHLC-AHGQCRNT-----EGSFQCVCDQGYRASGLGDHCEDINECL-EDKSVCQRGDCIN 306
Query: 489 TVGSFRCGCMTGYILRPDERSCKPTGE 515
T GS+ C C G+ L D ++C+ E
Sbjct: 307 TAGSYDCTCPDGFQL-DDNKTCQDINE 332
Score = 57.2 bits (132), Expect = 5e-07
Identities = 31/103 (30%), Positives = 54/103 (52%), Gaps = 7/103 (6%)
Query: 404 NCVNR--KHVCDGMKDCPRGDDEERCPLKRKCS-AEEKCEKLCITTYDGHAACACPMGFL 460
+C+N ++ C + + + +C +C+ + C + +G C CP GF+
Sbjct: 15 HCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFM 74
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCG-CMTGY 501
+E+ +C D+DEC+ + VC + C NTVG+FRC C +GY
Sbjct: 75 ASEEGTNCIDVDECL--RPDVCGEGHCVNTVGAFRCEYCDSGY 115
Score = 50.8 bits (116), Expect = 4e-05
Identities = 24/59 (40%), Positives = 32/59 (54%), Gaps = 2/59 (3%)
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGYILRPDERSC 510
C C G+ +E + C DIDEC Q +CSQ C NT GSF C C G++ + +C
Sbjct: 25 CICYEGYRFSEQQRKCVDIDECTQVQH-LCSQGRCENTEGSFLCICPAGFMASEEGTNC 82
Score = 47.2 bits (107), Expect = 5e-04
Identities = 27/82 (32%), Positives = 36/82 (43%), Gaps = 3/82 (3%)
Query: 436 EEKCEK-LCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFR 494
+E C+ C+ T G+ C C G K C D+DEC + Q C NT GS+
Sbjct: 560 QEICKNGFCLNTRPGYE-CYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQ-CVNTEGSYN 617
Query: 495 CGCMTGYILRPDERSCKPTGES 516
C C +L E+ C ES
Sbjct: 618 CFCTHPMVLDASEKRCIRPAES 639
Score = 46.8 bits (106), Expect = 7e-04
Identities = 58/240 (24%), Positives = 89/240 (37%), Gaps = 24/240 (10%)
Query: 266 IDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKC--IPERWRC 323
++ +CKNT+ F+C +D C + C C G+C ++C
Sbjct: 217 VNGQCKNTE---GSFRCTCGQGYQLSAAKDQCEDID-ECQHRHL-CAHGQCRNTEGSFQC 271
Query: 324 DNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNG---EDEMNC 380
++ G +C+ I C D+ C C+ D C +G +D C
Sbjct: 272 VCDQGYRASGLGDHCE--DINECLEDKSVCQRGDCINTAGSYDCT--CPDGFQLDDNKTC 327
Query: 381 EVSCE-EDQYTCRPQ-EHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEK 438
+ E E C PQ E L + +CV ++ D +D + C C +
Sbjct: 328 QDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISA-DGRTCEDIDECVNNTVCDSHGF 386
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQT-CSNTVGSFRCGC 497
C+ G C C GF +D C D++EC VC + C N GSF C C
Sbjct: 387 CDNTA-----GSFRCLCYQGFQAPQDGQGCVDVNECELLSG-VCGEAFCENVEGSFLCVC 440
>AB208801-1|BAD92038.1| 1348|Homo sapiens latent transforming growth
factor beta binding protein 1 isoform LTBP-1S varian
protein.
Length = 1348
Score = 69.3 bits (162), Expect = 1e-10
Identities = 76/281 (27%), Positives = 103/281 (36%), Gaps = 36/281 (12%)
Query: 263 CAEIDFECKNTKCVPKDFQCDGDNDC--GDWTDEDSCPMVPGSCNAGEFKCNDGKCIPER 320
C E F N +C+ D +C N C GD ++ + M SC+ G + D K +
Sbjct: 652 CTE-GFRGWNGQCLDVD-ECLEPNVCANGDCSNLEGSYMC--SCHKGYTRTPDHKHCRDI 707
Query: 321 WRCDNERDCADGG-----DELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNGE 375
C C +G C S + C D LC C N E
Sbjct: 708 DECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLC-AHGQCRNTE 766
Query: 376 DEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCD--------GMKDC--PRG---D 422
C C++ +H C+ K VC G DC P G D
Sbjct: 767 GSFQCV--CDQGYRASGLGDHCED--INECLEDKSVCQRGDCINTAGSYDCTCPDGFQLD 822
Query: 423 DEERCPLKRKCSAEEKC--EKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDP 480
D + C +C C + C+ T +G C C GF ++ D +C DIDEC+ +
Sbjct: 823 DNKTCQDINECEHPGLCGPQGECLNT-EGSFHCVCQQGFSISADGRTCEDIDECV--NNT 879
Query: 481 VCSQ--TCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTL 519
VC C NT GSFRC C G+ D + C E L
Sbjct: 880 VCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELL 920
Score = 64.1 bits (149), Expect = 4e-09
Identities = 78/275 (28%), Positives = 112/275 (40%), Gaps = 43/275 (15%)
Query: 262 RCAEIDFECKNTKCVPKDFQC---DGDNDC-----------GDWTDEDSCPMVPGSCNAG 307
RC +ID EC N P D QC G C G D D C + P C G
Sbjct: 622 RCEDID-ECLNPSTCP-DEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDEC-LEPNVCANG 678
Query: 308 EFKCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDG 367
+ +G + C + D +C+ I C C + +C K +G
Sbjct: 679 DCSNLEGS-----YMCSCHKGYTRTPDHKHCR--DIDECQQGNL-CVNGQC--KN--TEG 726
Query: 368 VRDCTNGED-EMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNR-KHVCD-GMKDCPRGDDE 424
CT G+ +++ ED C+ + RN + VCD G + GD
Sbjct: 727 SFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGD-- 784
Query: 425 ERCPLKRKCSAEEK-CEKL-CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC 482
C +C ++ C++ CI T G C CP GF L ++K +C+DI+EC E +C
Sbjct: 785 -HCEDINECLEDKSVCQRGDCINTA-GSYDCTCPDGFQLDDNK-TCQDINEC--EHPGLC 839
Query: 483 SQT--CSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C NT GSF C C G+ + D R+C+ E
Sbjct: 840 GPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDE 874
Score = 60.9 bits (141), Expect = 4e-08
Identities = 62/267 (23%), Positives = 105/267 (39%), Gaps = 26/267 (9%)
Query: 258 VELMRCAEIDFECKNTKCVPK--DFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK 315
+++ C D C CV F+C+ + T C + N C D +
Sbjct: 583 IDVDECLRPDV-CGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPST--CPDEQ 639
Query: 316 CI--PERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRC--VLKTWLCDGVRDC 371
C+ P ++C C +G N + + C L+ CA+ C + +++C +
Sbjct: 640 CVNSPGSYQCV---PCTEGFRGWNGQCLDVDEC-LEPNVCANGDCSNLEGSYMCSCHKGY 695
Query: 372 TNGEDEMNCEV--SCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPL 429
T D +C C++ Q +FR + + KD + +D + C
Sbjct: 696 TRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKD--QCEDIDECQH 753
Query: 430 KRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSN 488
+ C A +C +G C C G+ + C DI+EC+ E VC + C N
Sbjct: 754 RHLC-AHGQCRNT-----EGSFQCVCDQGYRASGLGDHCEDINECL-EDKSVCQRGDCIN 806
Query: 489 TVGSFRCGCMTGYILRPDERSCKPTGE 515
T GS+ C C G+ L D ++C+ E
Sbjct: 807 TAGSYDCTCPDGFQL-DDNKTCQDINE 832
Score = 57.2 bits (132), Expect = 5e-07
Identities = 31/103 (30%), Positives = 54/103 (52%), Gaps = 7/103 (6%)
Query: 404 NCVNR--KHVCDGMKDCPRGDDEERCPLKRKCS-AEEKCEKLCITTYDGHAACACPMGFL 460
+C+N ++ C + + + +C +C+ + C + +G C CP GF+
Sbjct: 515 HCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFM 574
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCG-CMTGY 501
+E+ +C D+DEC+ + VC + C NTVG+FRC C +GY
Sbjct: 575 ASEEGTNCIDVDECL--RPDVCGEGHCVNTVGAFRCEYCDSGY 615
Score = 50.8 bits (116), Expect = 4e-05
Identities = 24/59 (40%), Positives = 32/59 (54%), Gaps = 2/59 (3%)
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGYILRPDERSC 510
C C G+ +E + C DIDEC Q +CSQ C NT GSF C C G++ + +C
Sbjct: 525 CICYEGYRFSEQQRKCVDIDECTQVQH-LCSQGRCENTEGSFLCICPAGFMASEEGTNC 582
Score = 49.6 bits (113), Expect = 1e-04
Identities = 26/85 (30%), Positives = 41/85 (48%), Gaps = 5/85 (5%)
Query: 432 KCSAEEKCEK-LCITTYDGHAACACPMGFLLAEDKYSCRDIDEC--MYEQDPVCSQT-CS 487
+C CE C+ +G+ C C G+ L K +C D++EC + + +C C
Sbjct: 1251 ECGILNGCENGRCVRVQEGYT-CDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCI 1309
Query: 488 NTVGSFRCGCMTGYILRPDERSCKP 512
NT GS++C C+ GY+ C P
Sbjct: 1310 NTDGSYKCLCLPGYVPSDKPNYCTP 1334
Score = 47.2 bits (107), Expect = 5e-04
Identities = 27/82 (32%), Positives = 36/82 (43%), Gaps = 3/82 (3%)
Query: 436 EEKCEK-LCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFR 494
+E C+ C+ T G+ C C G K C D+DEC + Q C NT GS+
Sbjct: 1060 QEICKNGFCLNTRPGYE-CYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQ-CVNTEGSYN 1117
Query: 495 CGCMTGYILRPDERSCKPTGES 516
C C +L E+ C ES
Sbjct: 1118 CFCTHPMVLDASEKRCIRPAES 1139
Score = 46.8 bits (106), Expect = 7e-04
Identities = 58/240 (24%), Positives = 89/240 (37%), Gaps = 24/240 (10%)
Query: 266 IDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKC--IPERWRC 323
++ +CKNT+ F+C +D C + C C G+C ++C
Sbjct: 717 VNGQCKNTE---GSFRCTCGQGYQLSAAKDQCEDID-ECQHRHL-CAHGQCRNTEGSFQC 771
Query: 324 DNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVRDCTNG---EDEMNC 380
++ G +C+ I C D+ C C+ D C +G +D C
Sbjct: 772 VCDQGYRASGLGDHCE--DINECLEDKSVCQRGDCINTAGSYDCT--CPDGFQLDDNKTC 827
Query: 381 EVSCE-EDQYTCRPQ-EHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEK 438
+ E E C PQ E L + +CV ++ D +D + C C +
Sbjct: 828 QDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISA-DGRTCEDIDECVNNTVCDSHGF 886
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQT-CSNTVGSFRCGC 497
C+ G C C GF +D C D++EC VC + C N GSF C C
Sbjct: 887 CDNTA-----GSFRCLCYQGFQAPQDGQGCVDVNECELLSG-VCGEAFCENVEGSFLCVC 940
Score = 43.2 bits (97), Expect = 0.009
Identities = 27/78 (34%), Positives = 39/78 (50%), Gaps = 7/78 (8%)
Query: 437 EKCEKLCITTYDGH-AACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFR 494
+KC K +Y G+ C G+ + + C+DI+EC + VC C NT+GS+R
Sbjct: 275 QKCPKK--PSYHGYNQMMECLPGYKRVNNTF-CQDINECQLQG--VCPNGECLNTMGSYR 329
Query: 495 CGCMTGYILRPDERSCKP 512
C C G+ P SC P
Sbjct: 330 CTCKIGFGPDPTFSSCVP 347
>AY165865-1|AAO18147.1| 2809|Homo sapiens fibrillin-3 short form
precursor transcript variant 3 protein.
Length = 2809
Score = 68.9 bits (161), Expect = 2e-10
Identities = 65/235 (27%), Positives = 86/235 (36%), Gaps = 34/235 (14%)
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNS---IRNCSLD 349
D D C P C G DG ++C C G EL K + I CSL
Sbjct: 1071 DVDECARDPLLCRGGTCTNTDGS-----YKCQ----CPPG-HELTAKGTACEDIDECSLS 1120
Query: 350 EYTCADRRCV--LKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVN 407
+ C +CV + + C + D C V E CR Q +C+N
Sbjct: 1121 DGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGC-VDINE----CRVQN---GGCDVHCIN 1172
Query: 408 RKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCE---KLC----ITTYDGHAACACPMGFL 460
+G C G P R C+ ++CE ++C T G C C GF+
Sbjct: 1173 T----EGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFM 1228
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
D +C D+DEC C NT GSF C C GY++R C E
Sbjct: 1229 ATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDE 1283
Score = 66.5 bits (155), Expect = 8e-10
Identities = 34/92 (36%), Positives = 45/92 (48%), Gaps = 3/92 (3%)
Query: 423 DEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC 482
D + C +C+ C DG +C C GFLLA + C DIDEC + +C
Sbjct: 525 DGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDEC--QTPGIC 582
Query: 483 -SQTCSNTVGSFRCGCMTGYILRPDERSCKPT 513
+ C+NT GSFRC C+ G + D R C T
Sbjct: 583 VNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDT 614
Score = 64.9 bits (151), Expect = 2e-09
Identities = 32/71 (45%), Positives = 40/71 (56%), Gaps = 3/71 (4%)
Query: 432 KCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTV 490
+CS K C LC T G C+CP G+LL ED +C+D+DEC Q C C NTV
Sbjct: 2408 ECSQVPKPCTFLCKNT-KGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHN-CQFLCVNTV 2465
Query: 491 GSFRCGCMTGY 501
G+F C C G+
Sbjct: 2466 GAFTCRCPPGF 2476
Score = 64.5 bits (150), Expect = 3e-09
Identities = 66/250 (26%), Positives = 95/250 (38%), Gaps = 36/250 (14%)
Query: 293 DEDSCPMVPGS----CNAGEFKCNDGKCIPERWRCD-NERDCADGGDELNCKPNSIRNCS 347
D+ C +PG C G D + + CD N C G E N K + + +C
Sbjct: 1208 DQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCE-NTKGSFVCHCQ 1266
Query: 348 LDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEE--DQYTCRPQEHLMSNAFR-- 403
L R+ C V +C G + SC ++CR + + F
Sbjct: 1267 LGYMV---RKGATG---CSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH 1320
Query: 404 ---NCVNRKHVCDGMKDCPRGDDEERCPLKRK-------CSAEEKCEK---LC----ITT 446
CV+++H C DC RC ++ C ++C + LC
Sbjct: 1321 DLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN 1380
Query: 447 YDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCS-QTCSNTVGSFRCGCMTGYILRP 505
G C C MGF ED +C+D+DEC Q +C+ +C N G FRC C GY L
Sbjct: 1381 APGGYRCECEMGFDPTEDHRACQDVDEC--AQGNLCAFGSCENLPGMFRCICNGGYELDR 1438
Query: 506 DERSCKPTGE 515
+C E
Sbjct: 1439 GGGNCTDINE 1448
Score = 63.3 bits (147), Expect = 8e-09
Identities = 37/104 (35%), Positives = 48/104 (46%), Gaps = 9/104 (8%)
Query: 418 CPRG----DDEERCPLKRKC-SAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDID 472
CPRG +D C +C S + C+ LC+ T G C CP GF + +C D D
Sbjct: 2431 CPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTV-GAFTCRCPPGF--TQHHQACFDND 2487
Query: 473 ECMYEQDPVCSQT-CSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
EC + P + C NT GSFRC C G+ L C+ E
Sbjct: 2488 ECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNE 2531
Score = 60.5 bits (140), Expect = 5e-08
Identities = 32/95 (33%), Positives = 38/95 (40%), Gaps = 6/95 (6%)
Query: 423 DEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC 482
DE C L C G C CP GF + C+D+DEC + P C
Sbjct: 2568 DENECALSPPTCGSASCRNTL-----GGFRCVCPSGFDFDQALGGCQDVDECAGRRGP-C 2621
Query: 483 SQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESP 517
S +C+NT G F CGC GY G SP
Sbjct: 2622 SYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSP 2656
Score = 59.7 bits (138), Expect = 9e-08
Identities = 29/73 (39%), Positives = 36/73 (49%), Gaps = 2/73 (2%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
CI + G C C G+ +C D+DEC P C+ C NT GSF C C GY+
Sbjct: 2379 CINSL-GSFRCHCQAGYTPDATATTCLDMDECSQVPKP-CTFLCKNTKGSFLCSCPRGYL 2436
Query: 503 LRPDERSCKPTGE 515
L D R+CK E
Sbjct: 2437 LEEDGRTCKDLDE 2449
Score = 59.3 bits (137), Expect = 1e-07
Identities = 35/102 (34%), Positives = 44/102 (43%), Gaps = 10/102 (9%)
Query: 415 MKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
MK+C D+ R PL C T DG C CP G L +C DIDEC
Sbjct: 1066 MKNCMDVDECARDPLL--------CRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDEC 1117
Query: 475 MYEQDPVCSQ-TCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
D +C C N +G+F+C C G+ PD + C E
Sbjct: 1118 SLS-DGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINE 1158
Score = 58.8 bits (136), Expect = 2e-07
Identities = 56/221 (25%), Positives = 78/221 (35%), Gaps = 21/221 (9%)
Query: 307 GEFKCND-GKCIPERWRCDNERDCAD--GGDELNCKPNSIRNCSLDEYTCADR-RCVLKT 362
G C+D +C CD+ C + G C P + D + C D CV +
Sbjct: 1274 GATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVG----DGFECHDLDECVSQE 1329
Query: 363 WLCDGVRDCTN--GEDEMNCEVSCEEDQYTCRPQEHLMSNAFR----NCVNRK--HVCDG 414
C DC N G C D + C ++ N C+N + C+
Sbjct: 1330 HRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCEC 1389
Query: 415 MKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
+D C +C+ C G C C G+ L +C DI+EC
Sbjct: 1390 EMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINEC 1449
Query: 475 MYEQDPV-C-SQTCSNTVGSFRCGCMTGYILRPDERSCKPT 513
DPV C + C NT GS+ C C + L P C T
Sbjct: 1450 ---ADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDT 1487
Score = 57.6 bits (133), Expect = 4e-07
Identities = 32/95 (33%), Positives = 44/95 (46%), Gaps = 3/95 (3%)
Query: 423 DEERCPLKRKC-SAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV 481
D + C +C S C +G C CP GF + D C DIDEC E +
Sbjct: 1923 DGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDH--CIDIDECSEEPNLC 1980
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGES 516
TC+N+ GSF+C C G++L + C T +S
Sbjct: 1981 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQS 2015
Score = 56.4 bits (130), Expect = 9e-07
Identities = 27/54 (50%), Positives = 30/54 (55%), Gaps = 2/54 (3%)
Query: 449 GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGY 501
G CAC GF L + +C DIDEC D +C Q TC NT GSF C C GY
Sbjct: 1007 GSFHCACAGGFALDAQERNCTDIDECRISPD-LCGQGTCVNTPGSFECECFPGY 1059
Score = 56.4 bits (130), Expect = 9e-07
Identities = 49/190 (25%), Positives = 77/190 (40%), Gaps = 21/190 (11%)
Query: 339 KPNSIRNCSLDEYTCADRRCV--LKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEH 396
KP I C CA+ C+ + ++ C+ C G + + ++CE+ +
Sbjct: 1718 KPLDIDECGEIPAICANGICINQIGSFRCE----CPAGFNYNSILLACEDVDECGSRESP 1773
Query: 397 LMSNAFRNCVN-----RKHVCDGMKDCPRGDDEERCPLKRKC-SAEEKCEKLCITTYDGH 450
NA +C+N R G K P G C + +C C +G
Sbjct: 1774 CQQNA--DCINIPGSYRCKCTRGYKLSPGG----ACVGRNECREIPNVCSHGDCMDTEGS 1827
Query: 451 AACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSC 510
C C GF + D+ C DIDEC ++ P + TC N +GS+ C C G+++ C
Sbjct: 1828 YMCLCHRGFQASADQTLCMDIDEC--DRQPCGNGTCKNIIGSYNCLCFPGFVV-THNGDC 1884
Query: 511 KPTGESPTLL 520
E TL+
Sbjct: 1885 VDFDECTTLV 1894
Score = 54.8 bits (126), Expect = 3e-06
Identities = 68/259 (26%), Positives = 98/259 (37%), Gaps = 34/259 (13%)
Query: 275 CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGD 334
C P G + C D D C PG C G +G +RC A G D
Sbjct: 557 CKPGFLLAPGGHYC---MDIDEC-QTPGICVNGHCTNTEGS-----FRCQCLGGLAVGTD 607
Query: 335 ELNCKPNSIRN-C--SLDEYTCADR--RCVLKTWLCDGVRDCTNGEDEMNCEV-SCEEDQ 388
C +R+ C ++++ +CA V K+ C D GE C + E Q
Sbjct: 608 GRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKNSAEFQ 667
Query: 389 YTCRPQEHLMSNA--FRNCVNRKHVC-DGMKDCPRGDDEERCPLK-------RKCSAEEK 438
C + ++ C VC +G+ + RG C L + C+ ++
Sbjct: 668 ALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDE 727
Query: 439 C---EKLCITTY----DGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVG 491
C LC + G +C+CP GF +D C+D+DEC+ P S C N G
Sbjct: 728 CALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECL--SSPCVSGVCRNLAG 785
Query: 492 SFRCGCMTGYILRPDERSC 510
S+ C C G L P C
Sbjct: 786 SYTCKCGPGSRLDPSGTFC 804
Score = 54.4 bits (125), Expect = 4e-06
Identities = 24/75 (32%), Positives = 34/75 (45%), Gaps = 1/75 (1%)
Query: 427 CPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTC 486
C +C +C+ C G+ C+CP GF C D +EC S +C
Sbjct: 2526 CEDVNECDGPHRCQHGCQNQLGGYR-CSCPQGFTQHSQWAQCVDENECALSPPTCGSASC 2584
Query: 487 SNTVGSFRCGCMTGY 501
NT+G FRC C +G+
Sbjct: 2585 RNTLGGFRCVCPSGF 2599
Score = 53.2 bits (122), Expect = 8e-06
Identities = 24/66 (36%), Positives = 32/66 (48%)
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP 512
C C GF + +C D+DEC+ C NT GSF+C C G+ L PD ++C
Sbjct: 472 CRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVD 531
Query: 513 TGESPT 518
E T
Sbjct: 532 HNECAT 537
Score = 53.2 bits (122), Expect = 8e-06
Identities = 23/60 (38%), Positives = 31/60 (51%), Gaps = 1/60 (1%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T+ G C CP G+ L+E C DIDEC TC NT+G++ C C Y+
Sbjct: 1579 CVNTF-GSFQCECPPGYHLSEHTRICEDIDECSTHSSICGPGTCYNTLGNYTCVCPAEYL 1637
Score = 52.8 bits (121), Expect = 1e-05
Identities = 72/280 (25%), Positives = 105/280 (37%), Gaps = 37/280 (13%)
Query: 250 PRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEF 309
P W P EL C + C G +D + D + C PG C G
Sbjct: 2045 PGEGWGDPCEL--CPQEGSAAFQELCPFGHGAVPGPDDSRE--DVNECAENPGVCTNGVC 2100
Query: 310 KCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVR 369
DG +RC+ + +NC CS+ + C C T + G
Sbjct: 2101 VNTDGS-----FRCECPFGYSLDFTGINCVDTD--ECSVG-HPCGQGTC---TNVIGGFE 2149
Query: 370 -DCTNGEDEMNCEVSCEE-DQYTCRPQEHLMSNAFRNCVNRK--HVCDGMKDCPRG---- 421
C +G E ++CE+ D+ + P + AFR C N + ++C CP G
Sbjct: 2150 CACADGF-EPGLMMTCEDIDECSLNP----LLCAFR-CHNTEGSYLCT----CPAGYTLR 2199
Query: 422 DDEERCPLKRKCS-AEEKCEKLCITTYD--GHAACACPMGFL-LAEDKYSCRDIDECMYE 477
+D C +C+ ++ C + + G AC CP G L C D +EC +
Sbjct: 2200 EDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQ 2259
Query: 478 QDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESP 517
D + C NT GSFRC C G+ P C + P
Sbjct: 2260 PDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGP 2299
Score = 51.2 bits (117), Expect = 3e-05
Identities = 31/114 (27%), Positives = 43/114 (37%), Gaps = 6/114 (5%)
Query: 403 RNCVNRKHVCD-GMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLL 461
+N + +C G+ G D C L + A CE L G C C +G+
Sbjct: 661 KNSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENL-----RGSYRCVCNLGYEA 715
Query: 462 AEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C D+DEC + C N+ GS+ C C G+ D CK E
Sbjct: 716 GASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDE 769
Score = 51.2 bits (117), Expect = 3e-05
Identities = 41/139 (29%), Positives = 53/139 (38%), Gaps = 13/139 (9%)
Query: 385 EEDQYTCRPQEHLMS---NAFRNCVNRKHVCDGMKDCPRG--DDEERCPLKRKCSAEE-K 438
EED TC+ + S N CVN V CP G + C +CSA+
Sbjct: 2438 EEDGRTCKDLDECTSRQHNCQFLCVNT--VGAFTCRCPPGFTQHHQACFDNDECSAQPGP 2495
Query: 439 C--EKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCG 496
C C T G C C GF L + C D++EC + C C N +G +RC
Sbjct: 2496 CGAHGHCHNT-PGSFRCECHQGFTLVSSGHGCEDVNEC--DGPHRCQHGCQNQLGGYRCS 2552
Query: 497 CMTGYILRPDERSCKPTGE 515
C G+ C E
Sbjct: 2553 CPQGFTQHSQWAQCVDENE 2571
Score = 49.2 bits (112), Expect = 1e-04
Identities = 27/76 (35%), Positives = 35/76 (46%), Gaps = 2/76 (2%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T +G C C GF L+ D +C D +EC V + C N GSF C C G++
Sbjct: 505 CVNT-EGSFQCVCNAGFELSPDGKNCVDHNECATSTMCV-NGVCLNEDGSFSCLCKPGFL 562
Query: 503 LRPDERSCKPTGESPT 518
L P C E T
Sbjct: 563 LAPGGHYCMDIDECQT 578
Score = 49.2 bits (112), Expect = 1e-04
Identities = 27/72 (37%), Positives = 34/72 (47%), Gaps = 2/72 (2%)
Query: 449 GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCS-QTCSNTVGSFRCGCMTGYILRPDE 507
G C C GF++ + C D DEC VC C NT GSF C C G+ L D
Sbjct: 1866 GSYNCLCFPGFVVTHNG-DCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADG 1924
Query: 508 RSCKPTGESPTL 519
++C T E +L
Sbjct: 1925 KNCVDTNECLSL 1936
Score = 48.4 bits (110), Expect = 2e-04
Identities = 71/270 (26%), Positives = 99/270 (36%), Gaps = 38/270 (14%)
Query: 263 CAEIDFECKNTKCV--PKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKC--IP 318
CAE C N +C+ P ++C+ + D +C V C G C G C +P
Sbjct: 1366 CAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVD-ECAQGNL-CAFGSCENLP 1423
Query: 319 ERWRCDNERDCADGGDEL-----NCKPNSIRNCSLDEYTCADRRCVLK--TWLCDGVRDC 371
+RC +GG EL NC I C+ D C + C+ ++LC +D
Sbjct: 1424 GMFRC-----ICNGGYELDRGGGNC--TDINECA-DPVNCINGVCINTPGSYLCSCPQDF 1475
Query: 372 TNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKR 431
+ C + C + H ++ +C V C C L R
Sbjct: 1476 ELNPSGVGC---VDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCC-------CSLGR 1525
Query: 432 KCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSC--RDIDECMYEQDPVCSQ-TCSN 488
CE LC CP G ++ + DIDEC E +C C N
Sbjct: 1526 AWG--NPCE-LCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQ-ELPGLCQGGDCVN 1581
Query: 489 TVGSFRCGCMTGYILRPDERSCKPTGESPT 518
T GSF+C C GY L R C+ E T
Sbjct: 1582 TFGSFQCECPPGYHLSEHTRICEDIDECST 1611
Score = 48.0 bits (109), Expect = 3e-04
Identities = 24/64 (37%), Positives = 31/64 (48%), Gaps = 1/64 (1%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T G C C GF L D +C D +EC+ TC N GSFRC C G+
Sbjct: 1903 CLNTA-GSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQ 1961
Query: 503 LRPD 506
++ D
Sbjct: 1962 VQSD 1965
Score = 44.8 bits (101), Expect = 0.003
Identities = 24/69 (34%), Positives = 30/69 (43%), Gaps = 5/69 (7%)
Query: 452 ACACPMGFLLAEDKYSC-----RDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPD 506
A CP G A + +D++EC TC NTVGSF C C G+ L
Sbjct: 963 ASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQ 1022
Query: 507 ERSCKPTGE 515
ER+C E
Sbjct: 1023 ERNCTDIDE 1031
Score = 44.0 bits (99), Expect = 0.005
Identities = 23/72 (31%), Positives = 33/72 (45%), Gaps = 2/72 (2%)
Query: 455 CPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP-- 512
C GF+ +C+D+DEC +C N VGSF C C G+ L +C+
Sbjct: 232 CRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYR 291
Query: 513 TGESPTLLFSNR 524
G ++LF R
Sbjct: 292 AGACFSVLFGGR 303
Score = 41.5 bits (93), Expect = 0.027
Identities = 27/69 (39%), Positives = 31/69 (44%), Gaps = 5/69 (7%)
Query: 454 ACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQ-TCSNTVGSFRCGCMTGYILRPDERSCK 511
AC GF +C D++EC E P VC C NT GSFRC C G +L R C
Sbjct: 854 ACARGFARMTG-VTCDDVNEC--ESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCV 910
Query: 512 PTGESPTLL 520
P L
Sbjct: 911 DVRLEPCFL 919
Score = 41.1 bits (92), Expect = 0.035
Identities = 54/224 (24%), Positives = 73/224 (32%), Gaps = 24/224 (10%)
Query: 304 CNAGEFKCNDGKCIPERWRCDNERDCA-------DGGDELNCKPNSIRNCSLDEYTCADR 356
CNAG DGK + C C DG CKP + + + C D
Sbjct: 516 CNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFL--LAPGGHYCMDI 573
Query: 357 RCVLKTWLCDGVRDCTNGEDEMNCE----VSCEEDQYTCRPQEHLMSNAFRNCVNRKHVC 412
+C CTN E C+ ++ D C H+ S + K C
Sbjct: 574 DECQTPGICVNGH-CTNTEGSFRCQCLGGLAVGTDGRVC-VDTHVRSTCYGAI--EKGSC 629
Query: 413 DGMKDCPRG-DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDI 471
+ P E C E C+ LC C G + D RDI
Sbjct: 630 --ARPFPGTVTKSECCCANPDHGFGEPCQ-LCPAKNSAEFQALCSSGLGITTDG---RDI 683
Query: 472 DECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
+EC + + + C N GS+RC C GY + C E
Sbjct: 684 NECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDE 727
Score = 39.5 bits (88), Expect = 0.11
Identities = 20/73 (27%), Positives = 32/73 (43%), Gaps = 4/73 (5%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T + C C +G+ + + C D+DEC P C N G++ C C G+
Sbjct: 424 CLPTPSSYR-CECNVGYT-QDVRGECIDVDECT--SSPCHHGDCVNIPGTYHCRCYPGFQ 479
Query: 503 LRPDERSCKPTGE 515
P ++C E
Sbjct: 480 ATPTRQACVDVDE 492
Score = 39.5 bits (88), Expect = 0.11
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NGGC C+ G C+C G L DG+ CAD
Sbjct: 1159 CRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACAD 1196
Score = 37.9 bits (84), Expect = 0.33
Identities = 15/33 (45%), Positives = 18/33 (54%)
Query: 469 RDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGY 501
RD+DEC C N++GSFRC C GY
Sbjct: 2362 RDVDECRMLAHLCAHGECINSLGSFRCHCQAGY 2394
Score = 36.7 bits (81), Expect = 0.76
Identities = 15/38 (39%), Positives = 20/38 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C + C+ LC G C+CP G L +DG+TC D
Sbjct: 2409 CSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKD 2446
Score = 34.7 bits (76), Expect = 3.1
Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 2/36 (5%)
Query: 1023 NGGCSHL--CLLKPGGRSCACPIGIKLNKDGKTCAD 1056
+GG HL C+ G C C G +L+ DGK C D
Sbjct: 496 SGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVD 531
Score = 33.5 bits (73), Expect = 7.0
Identities = 14/39 (35%), Positives = 20/39 (51%), Gaps = 1/39 (2%)
Query: 1019 CGKNNGGCSH-LCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C +N G C++ +C+ G C CP G L+ G C D
Sbjct: 2088 CAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVD 2126
Score = 33.1 bits (72), Expect = 9.3
Identities = 11/26 (42%), Positives = 14/26 (53%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTG 1347
C G CS+ C +P G+ C CP G
Sbjct: 2614 CAGRRGPCSYSCANTPGGFLCGCPQG 2639
>AY165864-1|AAO18146.1| 2809|Homo sapiens fibrillin-3 short form
precursor transcript variant 2 protein.
Length = 2809
Score = 68.9 bits (161), Expect = 2e-10
Identities = 65/235 (27%), Positives = 86/235 (36%), Gaps = 34/235 (14%)
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNS---IRNCSLD 349
D D C P C G DG ++C C G EL K + I CSL
Sbjct: 1071 DVDECARDPLLCRGGTCTNTDGS-----YKCQ----CPPG-HELTAKGTACEDIDECSLS 1120
Query: 350 EYTCADRRCV--LKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVN 407
+ C +CV + + C + D C V E CR Q +C+N
Sbjct: 1121 DGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGC-VDINE----CRVQN---GGCDVHCIN 1172
Query: 408 RKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCE---KLC----ITTYDGHAACACPMGFL 460
+G C G P R C+ ++CE ++C T G C C GF+
Sbjct: 1173 T----EGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFM 1228
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
D +C D+DEC C NT GSF C C GY++R C E
Sbjct: 1229 ATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDE 1283
Score = 66.5 bits (155), Expect = 8e-10
Identities = 34/92 (36%), Positives = 45/92 (48%), Gaps = 3/92 (3%)
Query: 423 DEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC 482
D + C +C+ C DG +C C GFLLA + C DIDEC + +C
Sbjct: 525 DGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDEC--QTPGIC 582
Query: 483 -SQTCSNTVGSFRCGCMTGYILRPDERSCKPT 513
+ C+NT GSFRC C+ G + D R C T
Sbjct: 583 VNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDT 614
Score = 64.9 bits (151), Expect = 2e-09
Identities = 32/71 (45%), Positives = 40/71 (56%), Gaps = 3/71 (4%)
Query: 432 KCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTV 490
+CS K C LC T G C+CP G+LL ED +C+D+DEC Q C C NTV
Sbjct: 2408 ECSQVPKPCTFLCKNT-KGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHN-CQFLCVNTV 2465
Query: 491 GSFRCGCMTGY 501
G+F C C G+
Sbjct: 2466 GAFTCRCPPGF 2476
Score = 64.5 bits (150), Expect = 3e-09
Identities = 66/250 (26%), Positives = 95/250 (38%), Gaps = 36/250 (14%)
Query: 293 DEDSCPMVPGS----CNAGEFKCNDGKCIPERWRCD-NERDCADGGDELNCKPNSIRNCS 347
D+ C +PG C G D + + CD N C G E N K + + +C
Sbjct: 1208 DQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCE-NTKGSFVCHCQ 1266
Query: 348 LDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEE--DQYTCRPQEHLMSNAFR-- 403
L R+ C V +C G + SC ++CR + + F
Sbjct: 1267 LGYMV---RKGATG---CSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH 1320
Query: 404 ---NCVNRKHVCDGMKDCPRGDDEERCPLKRK-------CSAEEKCEK---LC----ITT 446
CV+++H C DC RC ++ C ++C + LC
Sbjct: 1321 DLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN 1380
Query: 447 YDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCS-QTCSNTVGSFRCGCMTGYILRP 505
G C C MGF ED +C+D+DEC Q +C+ +C N G FRC C GY L
Sbjct: 1381 APGGYRCECEMGFDPTEDHRACQDVDEC--AQGNLCAFGSCENLPGMFRCICNGGYELDR 1438
Query: 506 DERSCKPTGE 515
+C E
Sbjct: 1439 GGGNCTDINE 1448
Score = 63.3 bits (147), Expect = 8e-09
Identities = 37/104 (35%), Positives = 48/104 (46%), Gaps = 9/104 (8%)
Query: 418 CPRG----DDEERCPLKRKC-SAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDID 472
CPRG +D C +C S + C+ LC+ T G C CP GF + +C D D
Sbjct: 2431 CPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTV-GAFTCRCPPGF--TQHHQACFDND 2487
Query: 473 ECMYEQDPVCSQT-CSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
EC + P + C NT GSFRC C G+ L C+ E
Sbjct: 2488 ECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNE 2531
Score = 60.5 bits (140), Expect = 5e-08
Identities = 32/95 (33%), Positives = 38/95 (40%), Gaps = 6/95 (6%)
Query: 423 DEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC 482
DE C L C G C CP GF + C+D+DEC + P C
Sbjct: 2568 DENECALSPPTCGSASCRNTL-----GGFRCVCPSGFDFDQALGGCQDVDECAGRRGP-C 2621
Query: 483 SQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESP 517
S +C+NT G F CGC GY G SP
Sbjct: 2622 SYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSP 2656
Score = 59.7 bits (138), Expect = 9e-08
Identities = 29/73 (39%), Positives = 36/73 (49%), Gaps = 2/73 (2%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
CI + G C C G+ +C D+DEC P C+ C NT GSF C C GY+
Sbjct: 2379 CINSL-GSFRCHCQAGYTPDATATTCLDMDECSQVPKP-CTFLCKNTKGSFLCSCPRGYL 2436
Query: 503 LRPDERSCKPTGE 515
L D R+CK E
Sbjct: 2437 LEEDGRTCKDLDE 2449
Score = 59.3 bits (137), Expect = 1e-07
Identities = 35/102 (34%), Positives = 44/102 (43%), Gaps = 10/102 (9%)
Query: 415 MKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
MK+C D+ R PL C T DG C CP G L +C DIDEC
Sbjct: 1066 MKNCMDVDECARDPLL--------CRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDEC 1117
Query: 475 MYEQDPVCSQ-TCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
D +C C N +G+F+C C G+ PD + C E
Sbjct: 1118 SLS-DGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINE 1158
Score = 58.8 bits (136), Expect = 2e-07
Identities = 56/221 (25%), Positives = 78/221 (35%), Gaps = 21/221 (9%)
Query: 307 GEFKCND-GKCIPERWRCDNERDCAD--GGDELNCKPNSIRNCSLDEYTCADR-RCVLKT 362
G C+D +C CD+ C + G C P + D + C D CV +
Sbjct: 1274 GATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVG----DGFECHDLDECVSQE 1329
Query: 363 WLCDGVRDCTN--GEDEMNCEVSCEEDQYTCRPQEHLMSNAFR----NCVNRK--HVCDG 414
C DC N G C D + C ++ N C+N + C+
Sbjct: 1330 HRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCEC 1389
Query: 415 MKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
+D C +C+ C G C C G+ L +C DI+EC
Sbjct: 1390 EMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINEC 1449
Query: 475 MYEQDPV-C-SQTCSNTVGSFRCGCMTGYILRPDERSCKPT 513
DPV C + C NT GS+ C C + L P C T
Sbjct: 1450 ---ADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDT 1487
Score = 57.6 bits (133), Expect = 4e-07
Identities = 32/95 (33%), Positives = 44/95 (46%), Gaps = 3/95 (3%)
Query: 423 DEERCPLKRKC-SAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV 481
D + C +C S C +G C CP GF + D C DIDEC E +
Sbjct: 1923 DGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDH--CIDIDECSEEPNLC 1980
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGES 516
TC+N+ GSF+C C G++L + C T +S
Sbjct: 1981 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQS 2015
Score = 56.4 bits (130), Expect = 9e-07
Identities = 27/54 (50%), Positives = 30/54 (55%), Gaps = 2/54 (3%)
Query: 449 GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGY 501
G CAC GF L + +C DIDEC D +C Q TC NT GSF C C GY
Sbjct: 1007 GSFHCACAGGFALDAQERNCTDIDECRISPD-LCGQGTCVNTPGSFECECFPGY 1059
Score = 56.4 bits (130), Expect = 9e-07
Identities = 49/190 (25%), Positives = 77/190 (40%), Gaps = 21/190 (11%)
Query: 339 KPNSIRNCSLDEYTCADRRCV--LKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEH 396
KP I C CA+ C+ + ++ C+ C G + + ++CE+ +
Sbjct: 1718 KPLDIDECGEIPAICANGICINQIGSFRCE----CPAGFNYNSILLACEDVDECGSRESP 1773
Query: 397 LMSNAFRNCVN-----RKHVCDGMKDCPRGDDEERCPLKRKC-SAEEKCEKLCITTYDGH 450
NA +C+N R G K P G C + +C C +G
Sbjct: 1774 CQQNA--DCINIPGSYRCKCTRGYKLSPGG----ACVGRNECREIPNVCSHGDCMDTEGS 1827
Query: 451 AACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSC 510
C C GF + D+ C DIDEC ++ P + TC N +GS+ C C G+++ C
Sbjct: 1828 YMCLCHRGFQASADQTLCMDIDEC--DRQPCGNGTCKNIIGSYNCLCFPGFVV-THNGDC 1884
Query: 511 KPTGESPTLL 520
E TL+
Sbjct: 1885 VDFDECTTLV 1894
Score = 54.8 bits (126), Expect = 3e-06
Identities = 68/259 (26%), Positives = 98/259 (37%), Gaps = 34/259 (13%)
Query: 275 CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGD 334
C P G + C D D C PG C G +G +RC A G D
Sbjct: 557 CKPGFLLAPGGHYC---MDIDEC-QTPGICVNGHCTNTEGS-----FRCQCLGGLAVGTD 607
Query: 335 ELNCKPNSIRN-C--SLDEYTCADR--RCVLKTWLCDGVRDCTNGEDEMNCEV-SCEEDQ 388
C +R+ C ++++ +CA V K+ C D GE C + E Q
Sbjct: 608 GRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKNSAEFQ 667
Query: 389 YTCRPQEHLMSNA--FRNCVNRKHVC-DGMKDCPRGDDEERCPLK-------RKCSAEEK 438
C + ++ C VC +G+ + RG C L + C+ ++
Sbjct: 668 ALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDE 727
Query: 439 C---EKLCITTY----DGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVG 491
C LC + G +C+CP GF +D C+D+DEC+ P S C N G
Sbjct: 728 CALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECL--SSPCVSGVCRNLAG 785
Query: 492 SFRCGCMTGYILRPDERSC 510
S+ C C G L P C
Sbjct: 786 SYTCKCGPGSRLDPSGTFC 804
Score = 54.4 bits (125), Expect = 4e-06
Identities = 24/75 (32%), Positives = 34/75 (45%), Gaps = 1/75 (1%)
Query: 427 CPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTC 486
C +C +C+ C G+ C+CP GF C D +EC S +C
Sbjct: 2526 CEDVNECDGPHRCQHGCQNQLGGYR-CSCPQGFTQHSQWAQCVDENECALSPPTCGSASC 2584
Query: 487 SNTVGSFRCGCMTGY 501
NT+G FRC C +G+
Sbjct: 2585 RNTLGGFRCVCPSGF 2599
Score = 53.2 bits (122), Expect = 8e-06
Identities = 24/66 (36%), Positives = 32/66 (48%)
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP 512
C C GF + +C D+DEC+ C NT GSF+C C G+ L PD ++C
Sbjct: 472 CRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVD 531
Query: 513 TGESPT 518
E T
Sbjct: 532 HNECAT 537
Score = 53.2 bits (122), Expect = 8e-06
Identities = 23/60 (38%), Positives = 31/60 (51%), Gaps = 1/60 (1%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T+ G C CP G+ L+E C DIDEC TC NT+G++ C C Y+
Sbjct: 1579 CVNTF-GSFQCECPPGYHLSEHTRICEDIDECSTHSSICGPGTCYNTLGNYTCVCPAEYL 1637
Score = 52.8 bits (121), Expect = 1e-05
Identities = 72/280 (25%), Positives = 105/280 (37%), Gaps = 37/280 (13%)
Query: 250 PRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEF 309
P W P EL C + C G +D + D + C PG C G
Sbjct: 2045 PGEGWGDPCEL--CPQEGSAAFQELCPFGHGAVPGPDDSRE--DVNECAENPGVCTNGVC 2100
Query: 310 KCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVR 369
DG +RC+ + +NC CS+ + C C T + G
Sbjct: 2101 VNTDGS-----FRCECPFGYSLDFTGINCVDTD--ECSVG-HPCGQGTC---TNVIGGFE 2149
Query: 370 -DCTNGEDEMNCEVSCEE-DQYTCRPQEHLMSNAFRNCVNRK--HVCDGMKDCPRG---- 421
C +G E ++CE+ D+ + P + AFR C N + ++C CP G
Sbjct: 2150 CACADGF-EPGLMMTCEDIDECSLNP----LLCAFR-CHNTEGSYLCT----CPAGYTLR 2199
Query: 422 DDEERCPLKRKCS-AEEKCEKLCITTYD--GHAACACPMGFL-LAEDKYSCRDIDECMYE 477
+D C +C+ ++ C + + G AC CP G L C D +EC +
Sbjct: 2200 EDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQ 2259
Query: 478 QDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESP 517
D + C NT GSFRC C G+ P C + P
Sbjct: 2260 PDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGP 2299
Score = 51.2 bits (117), Expect = 3e-05
Identities = 31/114 (27%), Positives = 43/114 (37%), Gaps = 6/114 (5%)
Query: 403 RNCVNRKHVCD-GMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLL 461
+N + +C G+ G D C L + A CE L G C C +G+
Sbjct: 661 KNSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENL-----RGSYRCVCNLGYEA 715
Query: 462 AEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C D+DEC + C N+ GS+ C C G+ D CK E
Sbjct: 716 GASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDE 769
Score = 51.2 bits (117), Expect = 3e-05
Identities = 41/139 (29%), Positives = 53/139 (38%), Gaps = 13/139 (9%)
Query: 385 EEDQYTCRPQEHLMS---NAFRNCVNRKHVCDGMKDCPRG--DDEERCPLKRKCSAEE-K 438
EED TC+ + S N CVN V CP G + C +CSA+
Sbjct: 2438 EEDGRTCKDLDECTSRQHNCQFLCVNT--VGAFTCRCPPGFTQHHQACFDNDECSAQPGP 2495
Query: 439 C--EKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCG 496
C C T G C C GF L + C D++EC + C C N +G +RC
Sbjct: 2496 CGAHGHCHNT-PGSFRCECHQGFTLVSSGHGCEDVNEC--DGPHRCQHGCQNQLGGYRCS 2552
Query: 497 CMTGYILRPDERSCKPTGE 515
C G+ C E
Sbjct: 2553 CPQGFTQHSQWAQCVDENE 2571
Score = 49.2 bits (112), Expect = 1e-04
Identities = 27/76 (35%), Positives = 35/76 (46%), Gaps = 2/76 (2%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T +G C C GF L+ D +C D +EC V + C N GSF C C G++
Sbjct: 505 CVNT-EGSFQCVCNAGFELSPDGKNCVDHNECATSTMCV-NGVCLNEDGSFSCLCKPGFL 562
Query: 503 LRPDERSCKPTGESPT 518
L P C E T
Sbjct: 563 LAPGGHYCMDIDECQT 578
Score = 49.2 bits (112), Expect = 1e-04
Identities = 27/72 (37%), Positives = 34/72 (47%), Gaps = 2/72 (2%)
Query: 449 GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCS-QTCSNTVGSFRCGCMTGYILRPDE 507
G C C GF++ + C D DEC VC C NT GSF C C G+ L D
Sbjct: 1866 GSYNCLCFPGFVVTHNG-DCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADG 1924
Query: 508 RSCKPTGESPTL 519
++C T E +L
Sbjct: 1925 KNCVDTNECLSL 1936
Score = 48.4 bits (110), Expect = 2e-04
Identities = 71/270 (26%), Positives = 99/270 (36%), Gaps = 38/270 (14%)
Query: 263 CAEIDFECKNTKCV--PKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKC--IP 318
CAE C N +C+ P ++C+ + D +C V C G C G C +P
Sbjct: 1366 CAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVD-ECAQGNL-CAFGSCENLP 1423
Query: 319 ERWRCDNERDCADGGDEL-----NCKPNSIRNCSLDEYTCADRRCVLK--TWLCDGVRDC 371
+RC +GG EL NC I C+ D C + C+ ++LC +D
Sbjct: 1424 GMFRC-----ICNGGYELDRGGGNC--TDINECA-DPVNCINGVCINTPGSYLCSCPQDF 1475
Query: 372 TNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKR 431
+ C + C + H ++ +C V C C L R
Sbjct: 1476 ELNPSGVGC---VDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCC-------CSLGR 1525
Query: 432 KCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSC--RDIDECMYEQDPVCSQ-TCSN 488
CE LC CP G ++ + DIDEC E +C C N
Sbjct: 1526 AWG--NPCE-LCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQ-ELPGLCQGGDCVN 1581
Query: 489 TVGSFRCGCMTGYILRPDERSCKPTGESPT 518
T GSF+C C GY L R C+ E T
Sbjct: 1582 TFGSFQCECPPGYHLSEHTRICEDIDECST 1611
Score = 48.0 bits (109), Expect = 3e-04
Identities = 24/64 (37%), Positives = 31/64 (48%), Gaps = 1/64 (1%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T G C C GF L D +C D +EC+ TC N GSFRC C G+
Sbjct: 1903 CLNTA-GSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQ 1961
Query: 503 LRPD 506
++ D
Sbjct: 1962 VQSD 1965
Score = 44.8 bits (101), Expect = 0.003
Identities = 24/69 (34%), Positives = 30/69 (43%), Gaps = 5/69 (7%)
Query: 452 ACACPMGFLLAEDKYSC-----RDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPD 506
A CP G A + +D++EC TC NTVGSF C C G+ L
Sbjct: 963 ASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQ 1022
Query: 507 ERSCKPTGE 515
ER+C E
Sbjct: 1023 ERNCTDIDE 1031
Score = 44.0 bits (99), Expect = 0.005
Identities = 23/72 (31%), Positives = 33/72 (45%), Gaps = 2/72 (2%)
Query: 455 CPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP-- 512
C GF+ +C+D+DEC +C N VGSF C C G+ L +C+
Sbjct: 232 CRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYR 291
Query: 513 TGESPTLLFSNR 524
G ++LF R
Sbjct: 292 AGACFSVLFGGR 303
Score = 41.5 bits (93), Expect = 0.027
Identities = 27/69 (39%), Positives = 31/69 (44%), Gaps = 5/69 (7%)
Query: 454 ACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQ-TCSNTVGSFRCGCMTGYILRPDERSCK 511
AC GF +C D++EC E P VC C NT GSFRC C G +L R C
Sbjct: 854 ACARGFARMTG-VTCDDVNEC--ESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCV 910
Query: 512 PTGESPTLL 520
P L
Sbjct: 911 DVRLEPCFL 919
Score = 41.1 bits (92), Expect = 0.035
Identities = 54/224 (24%), Positives = 73/224 (32%), Gaps = 24/224 (10%)
Query: 304 CNAGEFKCNDGKCIPERWRCDNERDCA-------DGGDELNCKPNSIRNCSLDEYTCADR 356
CNAG DGK + C C DG CKP + + + C D
Sbjct: 516 CNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFL--LAPGGHYCMDI 573
Query: 357 RCVLKTWLCDGVRDCTNGEDEMNCE----VSCEEDQYTCRPQEHLMSNAFRNCVNRKHVC 412
+C CTN E C+ ++ D C H+ S + K C
Sbjct: 574 DECQTPGICVNGH-CTNTEGSFRCQCLGGLAVGTDGRVC-VDTHVRSTCYGAI--EKGSC 629
Query: 413 DGMKDCPRG-DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDI 471
+ P E C E C+ LC C G + D RDI
Sbjct: 630 --ARPFPGTVTKSECCCANPDHGFGEPCQ-LCPAKNSAEFQALCSSGLGITTDG---RDI 683
Query: 472 DECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
+EC + + + C N GS+RC C GY + C E
Sbjct: 684 NECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDE 727
Score = 39.5 bits (88), Expect = 0.11
Identities = 20/73 (27%), Positives = 32/73 (43%), Gaps = 4/73 (5%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T + C C +G+ + + C D+DEC P C N G++ C C G+
Sbjct: 424 CLPTPSSYR-CECNVGYT-QDVRGECIDVDECT--SSPCHHGDCVNIPGTYHCRCYPGFQ 479
Query: 503 LRPDERSCKPTGE 515
P ++C E
Sbjct: 480 ATPTRQACVDVDE 492
Score = 39.5 bits (88), Expect = 0.11
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NGGC C+ G C+C G L DG+ CAD
Sbjct: 1159 CRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACAD 1196
Score = 37.9 bits (84), Expect = 0.33
Identities = 15/33 (45%), Positives = 18/33 (54%)
Query: 469 RDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGY 501
RD+DEC C N++GSFRC C GY
Sbjct: 2362 RDVDECRMLAHLCAHGECINSLGSFRCHCQAGY 2394
Score = 36.7 bits (81), Expect = 0.76
Identities = 15/38 (39%), Positives = 20/38 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C + C+ LC G C+CP G L +DG+TC D
Sbjct: 2409 CSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKD 2446
Score = 34.7 bits (76), Expect = 3.1
Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 2/36 (5%)
Query: 1023 NGGCSHL--CLLKPGGRSCACPIGIKLNKDGKTCAD 1056
+GG HL C+ G C C G +L+ DGK C D
Sbjct: 496 SGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVD 531
Score = 33.5 bits (73), Expect = 7.0
Identities = 14/39 (35%), Positives = 20/39 (51%), Gaps = 1/39 (2%)
Query: 1019 CGKNNGGCSH-LCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C +N G C++ +C+ G C CP G L+ G C D
Sbjct: 2088 CAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVD 2126
Score = 33.1 bits (72), Expect = 9.3
Identities = 11/26 (42%), Positives = 14/26 (53%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTG 1347
C G CS+ C +P G+ C CP G
Sbjct: 2614 CAGRRGPCSYSCANTPGGFLCGCPQG 2639
>AY165863-1|AAO18145.1| 2809|Homo sapiens fibrillin-3 short form
precursor transcript variant 1 protein.
Length = 2809
Score = 68.9 bits (161), Expect = 2e-10
Identities = 65/235 (27%), Positives = 86/235 (36%), Gaps = 34/235 (14%)
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNS---IRNCSLD 349
D D C P C G DG ++C C G EL K + I CSL
Sbjct: 1071 DVDECARDPLLCRGGTCTNTDGS-----YKCQ----CPPG-HELTAKGTACEDIDECSLS 1120
Query: 350 EYTCADRRCV--LKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVN 407
+ C +CV + + C + D C V E CR Q +C+N
Sbjct: 1121 DGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGC-VDINE----CRVQN---GGCDVHCIN 1172
Query: 408 RKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCE---KLC----ITTYDGHAACACPMGFL 460
+G C G P R C+ ++CE ++C T G C C GF+
Sbjct: 1173 T----EGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFM 1228
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
D +C D+DEC C NT GSF C C GY++R C E
Sbjct: 1229 ATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDE 1283
Score = 66.5 bits (155), Expect = 8e-10
Identities = 34/92 (36%), Positives = 45/92 (48%), Gaps = 3/92 (3%)
Query: 423 DEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC 482
D + C +C+ C DG +C C GFLLA + C DIDEC + +C
Sbjct: 525 DGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDEC--QTPGIC 582
Query: 483 -SQTCSNTVGSFRCGCMTGYILRPDERSCKPT 513
+ C+NT GSFRC C+ G + D R C T
Sbjct: 583 VNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDT 614
Score = 64.9 bits (151), Expect = 2e-09
Identities = 32/71 (45%), Positives = 40/71 (56%), Gaps = 3/71 (4%)
Query: 432 KCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTV 490
+CS K C LC T G C+CP G+LL ED +C+D+DEC Q C C NTV
Sbjct: 2408 ECSQVPKPCTFLCKNT-KGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHN-CQFLCVNTV 2465
Query: 491 GSFRCGCMTGY 501
G+F C C G+
Sbjct: 2466 GAFTCRCPPGF 2476
Score = 64.5 bits (150), Expect = 3e-09
Identities = 66/250 (26%), Positives = 95/250 (38%), Gaps = 36/250 (14%)
Query: 293 DEDSCPMVPGS----CNAGEFKCNDGKCIPERWRCD-NERDCADGGDELNCKPNSIRNCS 347
D+ C +PG C G D + + CD N C G E N K + + +C
Sbjct: 1208 DQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCE-NTKGSFVCHCQ 1266
Query: 348 LDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEE--DQYTCRPQEHLMSNAFR-- 403
L R+ C V +C G + SC ++CR + + F
Sbjct: 1267 LGYMV---RKGATG---CSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH 1320
Query: 404 ---NCVNRKHVCDGMKDCPRGDDEERCPLKRK-------CSAEEKCEK---LC----ITT 446
CV+++H C DC RC ++ C ++C + LC
Sbjct: 1321 DLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN 1380
Query: 447 YDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCS-QTCSNTVGSFRCGCMTGYILRP 505
G C C MGF ED +C+D+DEC Q +C+ +C N G FRC C GY L
Sbjct: 1381 APGGYRCECEMGFDPTEDHRACQDVDEC--AQGNLCAFGSCENLPGMFRCICNGGYELDR 1438
Query: 506 DERSCKPTGE 515
+C E
Sbjct: 1439 GGGNCTDINE 1448
Score = 63.3 bits (147), Expect = 8e-09
Identities = 37/104 (35%), Positives = 48/104 (46%), Gaps = 9/104 (8%)
Query: 418 CPRG----DDEERCPLKRKC-SAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDID 472
CPRG +D C +C S + C+ LC+ T G C CP GF + +C D D
Sbjct: 2431 CPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTV-GAFTCRCPPGF--TQHHQACFDND 2487
Query: 473 ECMYEQDPVCSQT-CSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
EC + P + C NT GSFRC C G+ L C+ E
Sbjct: 2488 ECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNE 2531
Score = 60.5 bits (140), Expect = 5e-08
Identities = 32/95 (33%), Positives = 38/95 (40%), Gaps = 6/95 (6%)
Query: 423 DEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC 482
DE C L C G C CP GF + C+D+DEC + P C
Sbjct: 2568 DENECALSPPTCGSASCRNTL-----GGFRCVCPSGFDFDQALGGCQDVDECAGRRGP-C 2621
Query: 483 SQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESP 517
S +C+NT G F CGC GY G SP
Sbjct: 2622 SYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSP 2656
Score = 59.7 bits (138), Expect = 9e-08
Identities = 29/73 (39%), Positives = 36/73 (49%), Gaps = 2/73 (2%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
CI + G C C G+ +C D+DEC P C+ C NT GSF C C GY+
Sbjct: 2379 CINSL-GSFRCHCQAGYTPDATATTCLDMDECSQVPKP-CTFLCKNTKGSFLCSCPRGYL 2436
Query: 503 LRPDERSCKPTGE 515
L D R+CK E
Sbjct: 2437 LEEDGRTCKDLDE 2449
Score = 59.3 bits (137), Expect = 1e-07
Identities = 35/102 (34%), Positives = 44/102 (43%), Gaps = 10/102 (9%)
Query: 415 MKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
MK+C D+ R PL C T DG C CP G L +C DIDEC
Sbjct: 1066 MKNCMDVDECARDPLL--------CRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDEC 1117
Query: 475 MYEQDPVCSQ-TCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
D +C C N +G+F+C C G+ PD + C E
Sbjct: 1118 SLS-DGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINE 1158
Score = 58.8 bits (136), Expect = 2e-07
Identities = 56/221 (25%), Positives = 78/221 (35%), Gaps = 21/221 (9%)
Query: 307 GEFKCND-GKCIPERWRCDNERDCAD--GGDELNCKPNSIRNCSLDEYTCADR-RCVLKT 362
G C+D +C CD+ C + G C P + D + C D CV +
Sbjct: 1274 GATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVG----DGFECHDLDECVSQE 1329
Query: 363 WLCDGVRDCTN--GEDEMNCEVSCEEDQYTCRPQEHLMSNAFR----NCVNRK--HVCDG 414
C DC N G C D + C ++ N C+N + C+
Sbjct: 1330 HRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCEC 1389
Query: 415 MKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
+D C +C+ C G C C G+ L +C DI+EC
Sbjct: 1390 EMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINEC 1449
Query: 475 MYEQDPV-C-SQTCSNTVGSFRCGCMTGYILRPDERSCKPT 513
DPV C + C NT GS+ C C + L P C T
Sbjct: 1450 ---ADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDT 1487
Score = 57.6 bits (133), Expect = 4e-07
Identities = 32/95 (33%), Positives = 44/95 (46%), Gaps = 3/95 (3%)
Query: 423 DEERCPLKRKC-SAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV 481
D + C +C S C +G C CP GF + D C DIDEC E +
Sbjct: 1923 DGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDH--CIDIDECSEEPNLC 1980
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGES 516
TC+N+ GSF+C C G++L + C T +S
Sbjct: 1981 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQS 2015
Score = 56.4 bits (130), Expect = 9e-07
Identities = 27/54 (50%), Positives = 30/54 (55%), Gaps = 2/54 (3%)
Query: 449 GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGY 501
G CAC GF L + +C DIDEC D +C Q TC NT GSF C C GY
Sbjct: 1007 GSFHCACAGGFALDAQERNCTDIDECRISPD-LCGQGTCVNTPGSFECECFPGY 1059
Score = 56.4 bits (130), Expect = 9e-07
Identities = 49/190 (25%), Positives = 77/190 (40%), Gaps = 21/190 (11%)
Query: 339 KPNSIRNCSLDEYTCADRRCV--LKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEH 396
KP I C CA+ C+ + ++ C+ C G + + ++CE+ +
Sbjct: 1718 KPLDIDECGEIPAICANGICINQIGSFRCE----CPAGFNYNSILLACEDVDECGSRESP 1773
Query: 397 LMSNAFRNCVN-----RKHVCDGMKDCPRGDDEERCPLKRKC-SAEEKCEKLCITTYDGH 450
NA +C+N R G K P G C + +C C +G
Sbjct: 1774 CQQNA--DCINIPGSYRCKCTRGYKLSPGG----ACVGRNECREIPNVCSHGDCMDTEGS 1827
Query: 451 AACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSC 510
C C GF + D+ C DIDEC ++ P + TC N +GS+ C C G+++ C
Sbjct: 1828 YMCLCHRGFQASADQTLCMDIDEC--DRQPCGNGTCKNIIGSYNCLCFPGFVV-THNGDC 1884
Query: 511 KPTGESPTLL 520
E TL+
Sbjct: 1885 VDFDECTTLV 1894
Score = 54.8 bits (126), Expect = 3e-06
Identities = 68/259 (26%), Positives = 98/259 (37%), Gaps = 34/259 (13%)
Query: 275 CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGD 334
C P G + C D D C PG C G +G +RC A G D
Sbjct: 557 CKPGFLLAPGGHYC---MDIDEC-QTPGICVNGHCTNTEGS-----FRCQCLGGLAVGTD 607
Query: 335 ELNCKPNSIRN-C--SLDEYTCADR--RCVLKTWLCDGVRDCTNGEDEMNCEV-SCEEDQ 388
C +R+ C ++++ +CA V K+ C D GE C + E Q
Sbjct: 608 GRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKNSAEFQ 667
Query: 389 YTCRPQEHLMSNA--FRNCVNRKHVC-DGMKDCPRGDDEERCPLK-------RKCSAEEK 438
C + ++ C VC +G+ + RG C L + C+ ++
Sbjct: 668 ALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDE 727
Query: 439 C---EKLCITTY----DGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVG 491
C LC + G +C+CP GF +D C+D+DEC+ P S C N G
Sbjct: 728 CALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECL--SSPCVSGVCRNLAG 785
Query: 492 SFRCGCMTGYILRPDERSC 510
S+ C C G L P C
Sbjct: 786 SYTCKCGPGSRLDPSGTFC 804
Score = 54.4 bits (125), Expect = 4e-06
Identities = 24/75 (32%), Positives = 34/75 (45%), Gaps = 1/75 (1%)
Query: 427 CPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTC 486
C +C +C+ C G+ C+CP GF C D +EC S +C
Sbjct: 2526 CEDVNECDGPHRCQHGCQNQLGGYR-CSCPQGFTQHSQWAQCVDENECALSPPTCGSASC 2584
Query: 487 SNTVGSFRCGCMTGY 501
NT+G FRC C +G+
Sbjct: 2585 RNTLGGFRCVCPSGF 2599
Score = 53.2 bits (122), Expect = 8e-06
Identities = 24/66 (36%), Positives = 32/66 (48%)
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP 512
C C GF + +C D+DEC+ C NT GSF+C C G+ L PD ++C
Sbjct: 472 CRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVD 531
Query: 513 TGESPT 518
E T
Sbjct: 532 HNECAT 537
Score = 53.2 bits (122), Expect = 8e-06
Identities = 23/60 (38%), Positives = 31/60 (51%), Gaps = 1/60 (1%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T+ G C CP G+ L+E C DIDEC TC NT+G++ C C Y+
Sbjct: 1579 CVNTF-GSFQCECPPGYHLSEHTRICEDIDECSTHSSICGPGTCYNTLGNYTCVCPAEYL 1637
Score = 52.8 bits (121), Expect = 1e-05
Identities = 72/280 (25%), Positives = 105/280 (37%), Gaps = 37/280 (13%)
Query: 250 PRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEF 309
P W P EL C + C G +D + D + C PG C G
Sbjct: 2045 PGEGWGDPCEL--CPQEGSAAFQELCPFGHGAVPGPDDSRE--DVNECAENPGVCTNGVC 2100
Query: 310 KCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVR 369
DG +RC+ + +NC CS+ + C C T + G
Sbjct: 2101 VNTDGS-----FRCECPFGYSLDFTGINCVDTD--ECSVG-HPCGQGTC---TNVIGGFE 2149
Query: 370 -DCTNGEDEMNCEVSCEE-DQYTCRPQEHLMSNAFRNCVNRK--HVCDGMKDCPRG---- 421
C +G E ++CE+ D+ + P + AFR C N + ++C CP G
Sbjct: 2150 CACADGF-EPGLMMTCEDIDECSLNP----LLCAFR-CHNTEGSYLCT----CPAGYTLR 2199
Query: 422 DDEERCPLKRKCS-AEEKCEKLCITTYD--GHAACACPMGFL-LAEDKYSCRDIDECMYE 477
+D C +C+ ++ C + + G AC CP G L C D +EC +
Sbjct: 2200 EDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQ 2259
Query: 478 QDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESP 517
D + C NT GSFRC C G+ P C + P
Sbjct: 2260 PDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGP 2299
Score = 51.2 bits (117), Expect = 3e-05
Identities = 31/114 (27%), Positives = 43/114 (37%), Gaps = 6/114 (5%)
Query: 403 RNCVNRKHVCD-GMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLL 461
+N + +C G+ G D C L + A CE L G C C +G+
Sbjct: 661 KNSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENL-----RGSYRCVCNLGYEA 715
Query: 462 AEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C D+DEC + C N+ GS+ C C G+ D CK E
Sbjct: 716 GASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDE 769
Score = 51.2 bits (117), Expect = 3e-05
Identities = 41/139 (29%), Positives = 53/139 (38%), Gaps = 13/139 (9%)
Query: 385 EEDQYTCRPQEHLMS---NAFRNCVNRKHVCDGMKDCPRG--DDEERCPLKRKCSAEE-K 438
EED TC+ + S N CVN V CP G + C +CSA+
Sbjct: 2438 EEDGRTCKDLDECTSRQHNCQFLCVNT--VGAFTCRCPPGFTQHHQACFDNDECSAQPGP 2495
Query: 439 C--EKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCG 496
C C T G C C GF L + C D++EC + C C N +G +RC
Sbjct: 2496 CGAHGHCHNT-PGSFRCECHQGFTLVSSGHGCEDVNEC--DGPHRCQHGCQNQLGGYRCS 2552
Query: 497 CMTGYILRPDERSCKPTGE 515
C G+ C E
Sbjct: 2553 CPQGFTQHSQWAQCVDENE 2571
Score = 49.2 bits (112), Expect = 1e-04
Identities = 27/76 (35%), Positives = 35/76 (46%), Gaps = 2/76 (2%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T +G C C GF L+ D +C D +EC V + C N GSF C C G++
Sbjct: 505 CVNT-EGSFQCVCNAGFELSPDGKNCVDHNECATSTMCV-NGVCLNEDGSFSCLCKPGFL 562
Query: 503 LRPDERSCKPTGESPT 518
L P C E T
Sbjct: 563 LAPGGHYCMDIDECQT 578
Score = 49.2 bits (112), Expect = 1e-04
Identities = 27/72 (37%), Positives = 34/72 (47%), Gaps = 2/72 (2%)
Query: 449 GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCS-QTCSNTVGSFRCGCMTGYILRPDE 507
G C C GF++ + C D DEC VC C NT GSF C C G+ L D
Sbjct: 1866 GSYNCLCFPGFVVTHNG-DCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADG 1924
Query: 508 RSCKPTGESPTL 519
++C T E +L
Sbjct: 1925 KNCVDTNECLSL 1936
Score = 48.4 bits (110), Expect = 2e-04
Identities = 71/270 (26%), Positives = 99/270 (36%), Gaps = 38/270 (14%)
Query: 263 CAEIDFECKNTKCV--PKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKC--IP 318
CAE C N +C+ P ++C+ + D +C V C G C G C +P
Sbjct: 1366 CAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVD-ECAQGNL-CAFGSCENLP 1423
Query: 319 ERWRCDNERDCADGGDEL-----NCKPNSIRNCSLDEYTCADRRCVLK--TWLCDGVRDC 371
+RC +GG EL NC I C+ D C + C+ ++LC +D
Sbjct: 1424 GMFRC-----ICNGGYELDRGGGNC--TDINECA-DPVNCINGVCINTPGSYLCSCPQDF 1475
Query: 372 TNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKR 431
+ C + C + H ++ +C V C C L R
Sbjct: 1476 ELNPSGVGC---VDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCC-------CSLGR 1525
Query: 432 KCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSC--RDIDECMYEQDPVCSQ-TCSN 488
CE LC CP G ++ + DIDEC E +C C N
Sbjct: 1526 AWG--NPCE-LCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQ-ELPGLCQGGDCVN 1581
Query: 489 TVGSFRCGCMTGYILRPDERSCKPTGESPT 518
T GSF+C C GY L R C+ E T
Sbjct: 1582 TFGSFQCECPPGYHLSEHTRICEDIDECST 1611
Score = 48.0 bits (109), Expect = 3e-04
Identities = 24/64 (37%), Positives = 31/64 (48%), Gaps = 1/64 (1%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T G C C GF L D +C D +EC+ TC N GSFRC C G+
Sbjct: 1903 CLNTA-GSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQ 1961
Query: 503 LRPD 506
++ D
Sbjct: 1962 VQSD 1965
Score = 44.8 bits (101), Expect = 0.003
Identities = 24/69 (34%), Positives = 30/69 (43%), Gaps = 5/69 (7%)
Query: 452 ACACPMGFLLAEDKYSC-----RDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPD 506
A CP G A + +D++EC TC NTVGSF C C G+ L
Sbjct: 963 ASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQ 1022
Query: 507 ERSCKPTGE 515
ER+C E
Sbjct: 1023 ERNCTDIDE 1031
Score = 44.0 bits (99), Expect = 0.005
Identities = 23/72 (31%), Positives = 33/72 (45%), Gaps = 2/72 (2%)
Query: 455 CPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP-- 512
C GF+ +C+D+DEC +C N VGSF C C G+ L +C+
Sbjct: 232 CRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYR 291
Query: 513 TGESPTLLFSNR 524
G ++LF R
Sbjct: 292 AGACFSVLFGGR 303
Score = 41.5 bits (93), Expect = 0.027
Identities = 27/69 (39%), Positives = 31/69 (44%), Gaps = 5/69 (7%)
Query: 454 ACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQ-TCSNTVGSFRCGCMTGYILRPDERSCK 511
AC GF +C D++EC E P VC C NT GSFRC C G +L R C
Sbjct: 854 ACARGFARMTG-VTCDDVNEC--ESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCV 910
Query: 512 PTGESPTLL 520
P L
Sbjct: 911 DVRLEPCFL 919
Score = 41.1 bits (92), Expect = 0.035
Identities = 54/224 (24%), Positives = 73/224 (32%), Gaps = 24/224 (10%)
Query: 304 CNAGEFKCNDGKCIPERWRCDNERDCA-------DGGDELNCKPNSIRNCSLDEYTCADR 356
CNAG DGK + C C DG CKP + + + C D
Sbjct: 516 CNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFL--LAPGGHYCMDI 573
Query: 357 RCVLKTWLCDGVRDCTNGEDEMNCE----VSCEEDQYTCRPQEHLMSNAFRNCVNRKHVC 412
+C CTN E C+ ++ D C H+ S + K C
Sbjct: 574 DECQTPGICVNGH-CTNTEGSFRCQCLGGLAVGTDGRVC-VDTHVRSTCYGAI--EKGSC 629
Query: 413 DGMKDCPRG-DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDI 471
+ P E C E C+ LC C G + D RDI
Sbjct: 630 --ARPFPGTVTKSECCCANPDHGFGEPCQ-LCPAKNSAEFQALCSSGLGITTDG---RDI 683
Query: 472 DECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
+EC + + + C N GS+RC C GY + C E
Sbjct: 684 NECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDE 727
Score = 39.5 bits (88), Expect = 0.11
Identities = 20/73 (27%), Positives = 32/73 (43%), Gaps = 4/73 (5%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T + C C +G+ + + C D+DEC P C N G++ C C G+
Sbjct: 424 CLPTPSSYR-CECNVGYT-QDVRGECIDVDECT--SSPCHHGDCVNIPGTYHCRCYPGFQ 479
Query: 503 LRPDERSCKPTGE 515
P ++C E
Sbjct: 480 ATPTRQACVDVDE 492
Score = 39.5 bits (88), Expect = 0.11
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NGGC C+ G C+C G L DG+ CAD
Sbjct: 1159 CRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACAD 1196
Score = 37.9 bits (84), Expect = 0.33
Identities = 15/33 (45%), Positives = 18/33 (54%)
Query: 469 RDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGY 501
RD+DEC C N++GSFRC C GY
Sbjct: 2362 RDVDECRMLAHLCAHGECINSLGSFRCHCQAGY 2394
Score = 36.7 bits (81), Expect = 0.76
Identities = 15/38 (39%), Positives = 20/38 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C + C+ LC G C+CP G L +DG+TC D
Sbjct: 2409 CSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKD 2446
Score = 34.7 bits (76), Expect = 3.1
Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 2/36 (5%)
Query: 1023 NGGCSHL--CLLKPGGRSCACPIGIKLNKDGKTCAD 1056
+GG HL C+ G C C G +L+ DGK C D
Sbjct: 496 SGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVD 531
Score = 33.5 bits (73), Expect = 7.0
Identities = 14/39 (35%), Positives = 20/39 (51%), Gaps = 1/39 (2%)
Query: 1019 CGKNNGGCSH-LCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C +N G C++ +C+ G C CP G L+ G C D
Sbjct: 2088 CAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVD 2126
Score = 33.1 bits (72), Expect = 9.3
Identities = 11/26 (42%), Positives = 14/26 (53%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTG 1347
C G CS+ C +P G+ C CP G
Sbjct: 2614 CAGRRGPCSYSCANTPGGFLCGCPQG 2639
>AB177799-1|BAD16735.1| 2809|Homo sapiens fibrillin 3 protein.
Length = 2809
Score = 68.9 bits (161), Expect = 2e-10
Identities = 65/235 (27%), Positives = 86/235 (36%), Gaps = 34/235 (14%)
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNS---IRNCSLD 349
D D C P C G DG ++C C G EL K + I CSL
Sbjct: 1071 DVDECARDPLLCRGGTCTNTDGS-----YKCQ----CPPG-HELTAKGTACEDIDECSLS 1120
Query: 350 EYTCADRRCV--LKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVN 407
+ C +CV + + C + D C V E CR Q +C+N
Sbjct: 1121 DGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGC-VDINE----CRVQN---GGCDVHCIN 1172
Query: 408 RKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCE---KLC----ITTYDGHAACACPMGFL 460
+G C G P R C+ ++CE ++C T G C C GF+
Sbjct: 1173 T----EGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFM 1228
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
D +C D+DEC C NT GSF C C GY++R C E
Sbjct: 1229 ATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDE 1283
Score = 66.5 bits (155), Expect = 8e-10
Identities = 34/92 (36%), Positives = 45/92 (48%), Gaps = 3/92 (3%)
Query: 423 DEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC 482
D + C +C+ C DG +C C GFLLA + C DIDEC + +C
Sbjct: 525 DGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDEC--QTPGIC 582
Query: 483 -SQTCSNTVGSFRCGCMTGYILRPDERSCKPT 513
+ C+NT GSFRC C+ G + D R C T
Sbjct: 583 VNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDT 614
Score = 64.9 bits (151), Expect = 2e-09
Identities = 32/71 (45%), Positives = 40/71 (56%), Gaps = 3/71 (4%)
Query: 432 KCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTV 490
+CS K C LC T G C+CP G+LL ED +C+D+DEC Q C C NTV
Sbjct: 2408 ECSQVPKPCTFLCKNT-KGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHN-CQFLCVNTV 2465
Query: 491 GSFRCGCMTGY 501
G+F C C G+
Sbjct: 2466 GAFTCRCPPGF 2476
Score = 64.5 bits (150), Expect = 3e-09
Identities = 66/250 (26%), Positives = 95/250 (38%), Gaps = 36/250 (14%)
Query: 293 DEDSCPMVPGS----CNAGEFKCNDGKCIPERWRCD-NERDCADGGDELNCKPNSIRNCS 347
D+ C +PG C G D + + CD N C G E N K + + +C
Sbjct: 1208 DQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCE-NTKGSFVCHCQ 1266
Query: 348 LDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEE--DQYTCRPQEHLMSNAFR-- 403
L R+ C V +C G + SC ++CR + + F
Sbjct: 1267 LGYMV---RKGATG---CSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH 1320
Query: 404 ---NCVNRKHVCDGMKDCPRGDDEERCPLKRK-------CSAEEKCEK---LC----ITT 446
CV+++H C DC RC ++ C ++C + LC
Sbjct: 1321 DLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN 1380
Query: 447 YDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCS-QTCSNTVGSFRCGCMTGYILRP 505
G C C MGF ED +C+D+DEC Q +C+ +C N G FRC C GY L
Sbjct: 1381 APGGYRCECEMGFDPTEDHRACQDVDEC--AQGNLCAFGSCENLPGMFRCICNGGYELDR 1438
Query: 506 DERSCKPTGE 515
+C E
Sbjct: 1439 GGGNCTDINE 1448
Score = 63.3 bits (147), Expect = 8e-09
Identities = 37/104 (35%), Positives = 48/104 (46%), Gaps = 9/104 (8%)
Query: 418 CPRG----DDEERCPLKRKC-SAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDID 472
CPRG +D C +C S + C+ LC+ T G C CP GF + +C D D
Sbjct: 2431 CPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTV-GAFTCRCPPGF--TQHHQACFDND 2487
Query: 473 ECMYEQDPVCSQT-CSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
EC + P + C NT GSFRC C G+ L C+ E
Sbjct: 2488 ECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNE 2531
Score = 60.5 bits (140), Expect = 5e-08
Identities = 32/95 (33%), Positives = 38/95 (40%), Gaps = 6/95 (6%)
Query: 423 DEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC 482
DE C L C G C CP GF + C+D+DEC + P C
Sbjct: 2568 DENECALSPPTCGSASCRNTL-----GGFRCVCPSGFDFDQALGGCQDVDECAGRRGP-C 2621
Query: 483 SQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESP 517
S +C+NT G F CGC GY G SP
Sbjct: 2622 SYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSP 2656
Score = 59.7 bits (138), Expect = 9e-08
Identities = 29/73 (39%), Positives = 36/73 (49%), Gaps = 2/73 (2%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
CI + G C C G+ +C D+DEC P C+ C NT GSF C C GY+
Sbjct: 2379 CINSL-GSFRCHCQAGYTPDATATTCLDMDECSQVPKP-CTFLCKNTKGSFLCSCPRGYL 2436
Query: 503 LRPDERSCKPTGE 515
L D R+CK E
Sbjct: 2437 LEEDGRTCKDLDE 2449
Score = 59.3 bits (137), Expect = 1e-07
Identities = 35/102 (34%), Positives = 44/102 (43%), Gaps = 10/102 (9%)
Query: 415 MKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
MK+C D+ R PL C T DG C CP G L +C DIDEC
Sbjct: 1066 MKNCMDVDECARDPLL--------CRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDEC 1117
Query: 475 MYEQDPVCSQ-TCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
D +C C N +G+F+C C G+ PD + C E
Sbjct: 1118 SLS-DGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINE 1158
Score = 58.8 bits (136), Expect = 2e-07
Identities = 56/221 (25%), Positives = 78/221 (35%), Gaps = 21/221 (9%)
Query: 307 GEFKCND-GKCIPERWRCDNERDCAD--GGDELNCKPNSIRNCSLDEYTCADR-RCVLKT 362
G C+D +C CD+ C + G C P + D + C D CV +
Sbjct: 1274 GATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVG----DGFECHDLDECVSQE 1329
Query: 363 WLCDGVRDCTN--GEDEMNCEVSCEEDQYTCRPQEHLMSNAFR----NCVNRK--HVCDG 414
C DC N G C D + C ++ N C+N + C+
Sbjct: 1330 HRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCEC 1389
Query: 415 MKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
+D C +C+ C G C C G+ L +C DI+EC
Sbjct: 1390 EMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINEC 1449
Query: 475 MYEQDPV-C-SQTCSNTVGSFRCGCMTGYILRPDERSCKPT 513
DPV C + C NT GS+ C C + L P C T
Sbjct: 1450 ---ADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDT 1487
Score = 57.6 bits (133), Expect = 4e-07
Identities = 32/95 (33%), Positives = 44/95 (46%), Gaps = 3/95 (3%)
Query: 423 DEERCPLKRKC-SAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV 481
D + C +C S C +G C CP GF + D C DIDEC E +
Sbjct: 1923 DGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDH--CIDIDECSEEPNLC 1980
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGES 516
TC+N+ GSF+C C G++L + C T +S
Sbjct: 1981 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQS 2015
Score = 56.4 bits (130), Expect = 9e-07
Identities = 27/54 (50%), Positives = 30/54 (55%), Gaps = 2/54 (3%)
Query: 449 GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGY 501
G CAC GF L + +C DIDEC D +C Q TC NT GSF C C GY
Sbjct: 1007 GSFHCACAGGFALDAQERNCTDIDECRISPD-LCGQGTCVNTPGSFECECFPGY 1059
Score = 56.4 bits (130), Expect = 9e-07
Identities = 49/190 (25%), Positives = 77/190 (40%), Gaps = 21/190 (11%)
Query: 339 KPNSIRNCSLDEYTCADRRCV--LKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEH 396
KP I C CA+ C+ + ++ C+ C G + + ++CE+ +
Sbjct: 1718 KPLDIDECGEIPAICANGICINQIGSFRCE----CPAGFNYNSILLACEDVDECGSRESP 1773
Query: 397 LMSNAFRNCVN-----RKHVCDGMKDCPRGDDEERCPLKRKC-SAEEKCEKLCITTYDGH 450
NA +C+N R G K P G C + +C C +G
Sbjct: 1774 CQQNA--DCINIPGSYRCKCTRGYKLSPGG----ACVGRNECREIPNVCSHGDCMDTEGS 1827
Query: 451 AACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSC 510
C C GF + D+ C DIDEC ++ P + TC N +GS+ C C G+++ C
Sbjct: 1828 YMCLCHRGFQASADQTLCMDIDEC--DRQPCGNGTCKNIIGSYNCLCFPGFVV-THNGDC 1884
Query: 511 KPTGESPTLL 520
E TL+
Sbjct: 1885 VDFDECTTLV 1894
Score = 54.8 bits (126), Expect = 3e-06
Identities = 68/259 (26%), Positives = 98/259 (37%), Gaps = 34/259 (13%)
Query: 275 CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGD 334
C P G + C D D C PG C G +G +RC A G D
Sbjct: 557 CKPGFLLAPGGHYC---MDIDEC-QTPGICVNGHCTNTEGS-----FRCQCLGGLAVGTD 607
Query: 335 ELNCKPNSIRN-C--SLDEYTCADR--RCVLKTWLCDGVRDCTNGEDEMNCEV-SCEEDQ 388
C +R+ C ++++ +CA V K+ C D GE C + E Q
Sbjct: 608 GRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKNSAEFQ 667
Query: 389 YTCRPQEHLMSNA--FRNCVNRKHVC-DGMKDCPRGDDEERCPLK-------RKCSAEEK 438
C + ++ C VC +G+ + RG C L + C+ ++
Sbjct: 668 ALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDE 727
Query: 439 C---EKLCITTY----DGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVG 491
C LC + G +C+CP GF +D C+D+DEC+ P S C N G
Sbjct: 728 CALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECL--SSPCVSGVCRNLAG 785
Query: 492 SFRCGCMTGYILRPDERSC 510
S+ C C G L P C
Sbjct: 786 SYTCKCGPGSRLDPSGTFC 804
Score = 54.4 bits (125), Expect = 4e-06
Identities = 24/75 (32%), Positives = 34/75 (45%), Gaps = 1/75 (1%)
Query: 427 CPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTC 486
C +C +C+ C G+ C+CP GF C D +EC S +C
Sbjct: 2526 CEDVNECDGPHRCQHGCQNQLGGYR-CSCPQGFTQHSQWAQCVDENECALSPPTCGSASC 2584
Query: 487 SNTVGSFRCGCMTGY 501
NT+G FRC C +G+
Sbjct: 2585 RNTLGGFRCVCPSGF 2599
Score = 53.2 bits (122), Expect = 8e-06
Identities = 24/66 (36%), Positives = 32/66 (48%)
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP 512
C C GF + +C D+DEC+ C NT GSF+C C G+ L PD ++C
Sbjct: 472 CRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVD 531
Query: 513 TGESPT 518
E T
Sbjct: 532 HNECAT 537
Score = 53.2 bits (122), Expect = 8e-06
Identities = 23/60 (38%), Positives = 31/60 (51%), Gaps = 1/60 (1%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T+ G C CP G+ L+E C DIDEC TC NT+G++ C C Y+
Sbjct: 1579 CVNTF-GSFQCECPPGYHLSEHTRICEDIDECSTHSSICGPGTCYNTLGNYTCVCPAEYL 1637
Score = 52.8 bits (121), Expect = 1e-05
Identities = 72/280 (25%), Positives = 105/280 (37%), Gaps = 37/280 (13%)
Query: 250 PRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEF 309
P W P EL C + C G +D + D + C PG C G
Sbjct: 2045 PGEGWGDPCEL--CPQEGSAAFQELCPFGHGAVPGPDDSRE--DVNECAENPGVCTNGVC 2100
Query: 310 KCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVR 369
DG +RC+ + +NC CS+ + C C T + G
Sbjct: 2101 VNTDGS-----FRCECPFGYSLDFTGINCVDTD--ECSVG-HPCGQGTC---TNVIGGFE 2149
Query: 370 -DCTNGEDEMNCEVSCEE-DQYTCRPQEHLMSNAFRNCVNRK--HVCDGMKDCPRG---- 421
C +G E ++CE+ D+ + P + AFR C N + ++C CP G
Sbjct: 2150 CACADGF-EPGLMMTCEDIDECSLNP----LLCAFR-CHNTEGSYLCT----CPAGYTLR 2199
Query: 422 DDEERCPLKRKCS-AEEKCEKLCITTYD--GHAACACPMGFL-LAEDKYSCRDIDECMYE 477
+D C +C+ ++ C + + G AC CP G L C D +EC +
Sbjct: 2200 EDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQ 2259
Query: 478 QDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESP 517
D + C NT GSFRC C G+ P C + P
Sbjct: 2260 PDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGP 2299
Score = 51.2 bits (117), Expect = 3e-05
Identities = 31/114 (27%), Positives = 43/114 (37%), Gaps = 6/114 (5%)
Query: 403 RNCVNRKHVCD-GMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLL 461
+N + +C G+ G D C L + A CE L G C C +G+
Sbjct: 661 KNSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENL-----RGSYRCVCNLGYEA 715
Query: 462 AEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C D+DEC + C N+ GS+ C C G+ D CK E
Sbjct: 716 GASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDE 769
Score = 51.2 bits (117), Expect = 3e-05
Identities = 41/139 (29%), Positives = 53/139 (38%), Gaps = 13/139 (9%)
Query: 385 EEDQYTCRPQEHLMS---NAFRNCVNRKHVCDGMKDCPRG--DDEERCPLKRKCSAEE-K 438
EED TC+ + S N CVN V CP G + C +CSA+
Sbjct: 2438 EEDGRTCKDLDECTSRQHNCQFLCVNT--VGAFTCRCPPGFTQHHQACFDNDECSAQPGP 2495
Query: 439 C--EKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCG 496
C C T G C C GF L + C D++EC + C C N +G +RC
Sbjct: 2496 CGAHGHCHNT-PGSFRCECHQGFTLVSSGHGCEDVNEC--DGPHRCQHGCQNQLGGYRCS 2552
Query: 497 CMTGYILRPDERSCKPTGE 515
C G+ C E
Sbjct: 2553 CPQGFTQHSQWAQCVDENE 2571
Score = 49.2 bits (112), Expect = 1e-04
Identities = 27/76 (35%), Positives = 35/76 (46%), Gaps = 2/76 (2%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T +G C C GF L+ D +C D +EC V + C N GSF C C G++
Sbjct: 505 CVNT-EGSFQCVCNAGFELSPDGKNCVDHNECATSTMCV-NGVCLNEDGSFSCLCKPGFL 562
Query: 503 LRPDERSCKPTGESPT 518
L P C E T
Sbjct: 563 LAPGGHYCMDIDECQT 578
Score = 49.2 bits (112), Expect = 1e-04
Identities = 27/72 (37%), Positives = 34/72 (47%), Gaps = 2/72 (2%)
Query: 449 GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCS-QTCSNTVGSFRCGCMTGYILRPDE 507
G C C GF++ + C D DEC VC C NT GSF C C G+ L D
Sbjct: 1866 GSYNCLCFPGFVVTHNG-DCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADG 1924
Query: 508 RSCKPTGESPTL 519
++C T E +L
Sbjct: 1925 KNCVDTNECLSL 1936
Score = 48.4 bits (110), Expect = 2e-04
Identities = 71/270 (26%), Positives = 99/270 (36%), Gaps = 38/270 (14%)
Query: 263 CAEIDFECKNTKCV--PKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKC--IP 318
CAE C N +C+ P ++C+ + D +C V C G C G C +P
Sbjct: 1366 CAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVD-ECAQGNL-CAFGSCENLP 1423
Query: 319 ERWRCDNERDCADGGDEL-----NCKPNSIRNCSLDEYTCADRRCVLK--TWLCDGVRDC 371
+RC +GG EL NC I C+ D C + C+ ++LC +D
Sbjct: 1424 GMFRC-----ICNGGYELDRGGGNC--TDINECA-DPVNCINGVCINTPGSYLCSCPQDF 1475
Query: 372 TNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKR 431
+ C + C + H ++ +C V C C L R
Sbjct: 1476 ELNPSGVGC---VDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCC-------CSLGR 1525
Query: 432 KCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSC--RDIDECMYEQDPVCSQ-TCSN 488
CE LC CP G ++ + DIDEC E +C C N
Sbjct: 1526 AWG--NPCE-LCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQ-ELPGLCQGGDCVN 1581
Query: 489 TVGSFRCGCMTGYILRPDERSCKPTGESPT 518
T GSF+C C GY L R C+ E T
Sbjct: 1582 TFGSFQCECPPGYHLSEHTRICEDIDECST 1611
Score = 48.0 bits (109), Expect = 3e-04
Identities = 24/64 (37%), Positives = 31/64 (48%), Gaps = 1/64 (1%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T G C C GF L D +C D +EC+ TC N GSFRC C G+
Sbjct: 1903 CLNTA-GSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQ 1961
Query: 503 LRPD 506
++ D
Sbjct: 1962 VQSD 1965
Score = 44.8 bits (101), Expect = 0.003
Identities = 24/69 (34%), Positives = 30/69 (43%), Gaps = 5/69 (7%)
Query: 452 ACACPMGFLLAEDKYSC-----RDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPD 506
A CP G A + +D++EC TC NTVGSF C C G+ L
Sbjct: 963 ASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQ 1022
Query: 507 ERSCKPTGE 515
ER+C E
Sbjct: 1023 ERNCTDIDE 1031
Score = 44.0 bits (99), Expect = 0.005
Identities = 23/72 (31%), Positives = 33/72 (45%), Gaps = 2/72 (2%)
Query: 455 CPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP-- 512
C GF+ +C+D+DEC +C N VGSF C C G+ L +C+
Sbjct: 232 CRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYR 291
Query: 513 TGESPTLLFSNR 524
G ++LF R
Sbjct: 292 AGACFSVLFGGR 303
Score = 41.5 bits (93), Expect = 0.027
Identities = 27/69 (39%), Positives = 31/69 (44%), Gaps = 5/69 (7%)
Query: 454 ACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQ-TCSNTVGSFRCGCMTGYILRPDERSCK 511
AC GF +C D++EC E P VC C NT GSFRC C G +L R C
Sbjct: 854 ACARGFARMTG-VTCDDVNEC--ESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCV 910
Query: 512 PTGESPTLL 520
P L
Sbjct: 911 DVRLEPCFL 919
Score = 41.1 bits (92), Expect = 0.035
Identities = 54/224 (24%), Positives = 73/224 (32%), Gaps = 24/224 (10%)
Query: 304 CNAGEFKCNDGKCIPERWRCDNERDCA-------DGGDELNCKPNSIRNCSLDEYTCADR 356
CNAG DGK + C C DG CKP + + + C D
Sbjct: 516 CNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFL--LAPGGHYCMDI 573
Query: 357 RCVLKTWLCDGVRDCTNGEDEMNCE----VSCEEDQYTCRPQEHLMSNAFRNCVNRKHVC 412
+C CTN E C+ ++ D C H+ S + K C
Sbjct: 574 DECQTPGICVNGH-CTNTEGSFRCQCLGGLAVGTDGRVC-VDTHVRSTCYGAI--EKGSC 629
Query: 413 DGMKDCPRG-DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDI 471
+ P E C E C+ LC C G + D RDI
Sbjct: 630 --ARPFPGTVTKSECCCANPDHGFGEPCQ-LCPAKNSAEFQALCSSGLGITTDG---RDI 683
Query: 472 DECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
+EC + + + C N GS+RC C GY + C E
Sbjct: 684 NECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDE 727
Score = 39.5 bits (88), Expect = 0.11
Identities = 20/73 (27%), Positives = 32/73 (43%), Gaps = 4/73 (5%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T + C C +G+ + + C D+DEC P C N G++ C C G+
Sbjct: 424 CLPTPSSYR-CECNVGYT-QDVRGECIDVDECT--SSPCHHGDCVNIPGTYHCRCYPGFQ 479
Query: 503 LRPDERSCKPTGE 515
P ++C E
Sbjct: 480 ATPTRQACVDVDE 492
Score = 39.5 bits (88), Expect = 0.11
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NGGC C+ G C+C G L DG+ CAD
Sbjct: 1159 CRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACAD 1196
Score = 37.9 bits (84), Expect = 0.33
Identities = 15/33 (45%), Positives = 18/33 (54%)
Query: 469 RDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGY 501
RD+DEC C N++GSFRC C GY
Sbjct: 2362 RDVDECRMLAHLCAHGECINSLGSFRCHCQAGY 2394
Score = 36.7 bits (81), Expect = 0.76
Identities = 15/38 (39%), Positives = 20/38 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C + C+ LC G C+CP G L +DG+TC D
Sbjct: 2409 CSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKD 2446
Score = 34.7 bits (76), Expect = 3.1
Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 2/36 (5%)
Query: 1023 NGGCSHL--CLLKPGGRSCACPIGIKLNKDGKTCAD 1056
+GG HL C+ G C C G +L+ DGK C D
Sbjct: 496 SGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVD 531
Score = 33.5 bits (73), Expect = 7.0
Identities = 14/39 (35%), Positives = 20/39 (51%), Gaps = 1/39 (2%)
Query: 1019 CGKNNGGCSH-LCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C +N G C++ +C+ G C CP G L+ G C D
Sbjct: 2088 CAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVD 2126
Score = 33.1 bits (72), Expect = 9.3
Identities = 11/26 (42%), Positives = 14/26 (53%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTG 1347
C G CS+ C +P G+ C CP G
Sbjct: 2614 CAGRRGPCSYSCANTPGGFLCGCPQG 2639
>AB177798-1|BAD16734.1| 2809|Homo sapiens fibrillin 3 protein.
Length = 2809
Score = 68.9 bits (161), Expect = 2e-10
Identities = 65/235 (27%), Positives = 86/235 (36%), Gaps = 34/235 (14%)
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNS---IRNCSLD 349
D D C P C G DG ++C C G EL K + I CSL
Sbjct: 1071 DVDECARDPLLCRGGTCTNTDGS-----YKCQ----CPPG-HELTAKGTACEDIDECSLS 1120
Query: 350 EYTCADRRCV--LKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVN 407
+ C +CV + + C + D C V E CR Q +C+N
Sbjct: 1121 DGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGC-VDINE----CRVQN---GGCDVHCIN 1172
Query: 408 RKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCE---KLC----ITTYDGHAACACPMGFL 460
+G C G P R C+ ++CE ++C T G C C GF+
Sbjct: 1173 T----EGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFM 1228
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
D +C D+DEC C NT GSF C C GY++R C E
Sbjct: 1229 ATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDE 1283
Score = 66.5 bits (155), Expect = 8e-10
Identities = 34/92 (36%), Positives = 45/92 (48%), Gaps = 3/92 (3%)
Query: 423 DEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC 482
D + C +C+ C DG +C C GFLLA + C DIDEC + +C
Sbjct: 525 DGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDEC--QTPGIC 582
Query: 483 -SQTCSNTVGSFRCGCMTGYILRPDERSCKPT 513
+ C+NT GSFRC C+ G + D R C T
Sbjct: 583 VNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDT 614
Score = 64.9 bits (151), Expect = 2e-09
Identities = 32/71 (45%), Positives = 40/71 (56%), Gaps = 3/71 (4%)
Query: 432 KCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTV 490
+CS K C LC T G C+CP G+LL ED +C+D+DEC Q C C NTV
Sbjct: 2408 ECSQVPKPCTFLCKNT-KGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHN-CQFLCVNTV 2465
Query: 491 GSFRCGCMTGY 501
G+F C C G+
Sbjct: 2466 GAFTCRCPPGF 2476
Score = 64.5 bits (150), Expect = 3e-09
Identities = 66/250 (26%), Positives = 95/250 (38%), Gaps = 36/250 (14%)
Query: 293 DEDSCPMVPGS----CNAGEFKCNDGKCIPERWRCD-NERDCADGGDELNCKPNSIRNCS 347
D+ C +PG C G D + + CD N C G E N K + + +C
Sbjct: 1208 DQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCE-NTKGSFVCHCQ 1266
Query: 348 LDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEE--DQYTCRPQEHLMSNAFR-- 403
L R+ C V +C G + SC ++CR + + F
Sbjct: 1267 LGYMV---RKGATG---CSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH 1320
Query: 404 ---NCVNRKHVCDGMKDCPRGDDEERCPLKRK-------CSAEEKCEK---LC----ITT 446
CV+++H C DC RC ++ C ++C + LC
Sbjct: 1321 DLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN 1380
Query: 447 YDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCS-QTCSNTVGSFRCGCMTGYILRP 505
G C C MGF ED +C+D+DEC Q +C+ +C N G FRC C GY L
Sbjct: 1381 APGGYRCECEMGFDPTEDHRACQDVDEC--AQGNLCAFGSCENLPGMFRCICNGGYELDR 1438
Query: 506 DERSCKPTGE 515
+C E
Sbjct: 1439 GGGNCTDINE 1448
Score = 63.3 bits (147), Expect = 8e-09
Identities = 37/104 (35%), Positives = 48/104 (46%), Gaps = 9/104 (8%)
Query: 418 CPRG----DDEERCPLKRKC-SAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDID 472
CPRG +D C +C S + C+ LC+ T G C CP GF + +C D D
Sbjct: 2431 CPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTV-GAFTCRCPPGF--TQHHQACFDND 2487
Query: 473 ECMYEQDPVCSQT-CSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
EC + P + C NT GSFRC C G+ L C+ E
Sbjct: 2488 ECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNE 2531
Score = 60.5 bits (140), Expect = 5e-08
Identities = 32/95 (33%), Positives = 38/95 (40%), Gaps = 6/95 (6%)
Query: 423 DEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC 482
DE C L C G C CP GF + C+D+DEC + P C
Sbjct: 2568 DENECALSPPTCGSASCRNTL-----GGFRCVCPSGFDFDQALGGCQDVDECAGRRGP-C 2621
Query: 483 SQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESP 517
S +C+NT G F CGC GY G SP
Sbjct: 2622 SYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSP 2656
Score = 59.7 bits (138), Expect = 9e-08
Identities = 29/73 (39%), Positives = 36/73 (49%), Gaps = 2/73 (2%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
CI + G C C G+ +C D+DEC P C+ C NT GSF C C GY+
Sbjct: 2379 CINSL-GSFRCHCQAGYTPDATATTCLDMDECSQVPKP-CTFLCKNTKGSFLCSCPRGYL 2436
Query: 503 LRPDERSCKPTGE 515
L D R+CK E
Sbjct: 2437 LEEDGRTCKDLDE 2449
Score = 59.3 bits (137), Expect = 1e-07
Identities = 35/102 (34%), Positives = 44/102 (43%), Gaps = 10/102 (9%)
Query: 415 MKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
MK+C D+ R PL C T DG C CP G L +C DIDEC
Sbjct: 1066 MKNCMDVDECARDPLL--------CRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDEC 1117
Query: 475 MYEQDPVCSQ-TCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
D +C C N +G+F+C C G+ PD + C E
Sbjct: 1118 SLS-DGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINE 1158
Score = 58.8 bits (136), Expect = 2e-07
Identities = 56/221 (25%), Positives = 78/221 (35%), Gaps = 21/221 (9%)
Query: 307 GEFKCND-GKCIPERWRCDNERDCAD--GGDELNCKPNSIRNCSLDEYTCADR-RCVLKT 362
G C+D +C CD+ C + G C P + D + C D CV +
Sbjct: 1274 GATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVG----DGFECHDLDECVSQE 1329
Query: 363 WLCDGVRDCTN--GEDEMNCEVSCEEDQYTCRPQEHLMSNAFR----NCVNRK--HVCDG 414
C DC N G C D + C ++ N C+N + C+
Sbjct: 1330 HRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCEC 1389
Query: 415 MKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
+D C +C+ C G C C G+ L +C DI+EC
Sbjct: 1390 EMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINEC 1449
Query: 475 MYEQDPV-C-SQTCSNTVGSFRCGCMTGYILRPDERSCKPT 513
DPV C + C NT GS+ C C + L P C T
Sbjct: 1450 ---ADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDT 1487
Score = 57.6 bits (133), Expect = 4e-07
Identities = 32/95 (33%), Positives = 44/95 (46%), Gaps = 3/95 (3%)
Query: 423 DEERCPLKRKC-SAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV 481
D + C +C S C +G C CP GF + D C DIDEC E +
Sbjct: 1923 DGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDH--CIDIDECSEEPNLC 1980
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGES 516
TC+N+ GSF+C C G++L + C T +S
Sbjct: 1981 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQS 2015
Score = 56.4 bits (130), Expect = 9e-07
Identities = 27/54 (50%), Positives = 30/54 (55%), Gaps = 2/54 (3%)
Query: 449 GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGY 501
G CAC GF L + +C DIDEC D +C Q TC NT GSF C C GY
Sbjct: 1007 GSFHCACAGGFALDAQERNCTDIDECRISPD-LCGQGTCVNTPGSFECECFPGY 1059
Score = 56.4 bits (130), Expect = 9e-07
Identities = 49/190 (25%), Positives = 77/190 (40%), Gaps = 21/190 (11%)
Query: 339 KPNSIRNCSLDEYTCADRRCV--LKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEH 396
KP I C CA+ C+ + ++ C+ C G + + ++CE+ +
Sbjct: 1718 KPLDIDECGEIPAICANGICINQIGSFRCE----CPAGFNYNSILLACEDVDECGSRESP 1773
Query: 397 LMSNAFRNCVN-----RKHVCDGMKDCPRGDDEERCPLKRKC-SAEEKCEKLCITTYDGH 450
NA +C+N R G K P G C + +C C +G
Sbjct: 1774 CQQNA--DCINIPGSYRCKCTRGYKLSPGG----ACVGRNECREIPNVCSHGDCMDTEGS 1827
Query: 451 AACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSC 510
C C GF + D+ C DIDEC ++ P + TC N +GS+ C C G+++ C
Sbjct: 1828 YMCLCHRGFQASADQTLCMDIDEC--DRQPCGNGTCKNIIGSYNCLCFPGFVV-THNGDC 1884
Query: 511 KPTGESPTLL 520
E TL+
Sbjct: 1885 VDFDECTTLV 1894
Score = 54.8 bits (126), Expect = 3e-06
Identities = 68/259 (26%), Positives = 98/259 (37%), Gaps = 34/259 (13%)
Query: 275 CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGD 334
C P G + C D D C PG C G +G +RC A G D
Sbjct: 557 CKPGFLLAPGGHYC---MDIDEC-QTPGICVNGHCTNTEGS-----FRCQCLGGLAVGTD 607
Query: 335 ELNCKPNSIRN-C--SLDEYTCADR--RCVLKTWLCDGVRDCTNGEDEMNCEV-SCEEDQ 388
C +R+ C ++++ +CA V K+ C D GE C + E Q
Sbjct: 608 GRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKNSAEFQ 667
Query: 389 YTCRPQEHLMSNA--FRNCVNRKHVC-DGMKDCPRGDDEERCPLK-------RKCSAEEK 438
C + ++ C VC +G+ + RG C L + C+ ++
Sbjct: 668 ALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDE 727
Query: 439 C---EKLCITTY----DGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVG 491
C LC + G +C+CP GF +D C+D+DEC+ P S C N G
Sbjct: 728 CALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECL--SSPCVSGVCRNLAG 785
Query: 492 SFRCGCMTGYILRPDERSC 510
S+ C C G L P C
Sbjct: 786 SYTCKCGPGSRLDPSGTFC 804
Score = 54.4 bits (125), Expect = 4e-06
Identities = 24/75 (32%), Positives = 34/75 (45%), Gaps = 1/75 (1%)
Query: 427 CPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTC 486
C +C +C+ C G+ C+CP GF C D +EC S +C
Sbjct: 2526 CEDVNECDGPHRCQHGCQNQLGGYR-CSCPQGFTQHSQWAQCVDENECALSPPTCGSASC 2584
Query: 487 SNTVGSFRCGCMTGY 501
NT+G FRC C +G+
Sbjct: 2585 RNTLGGFRCVCPSGF 2599
Score = 53.2 bits (122), Expect = 8e-06
Identities = 24/66 (36%), Positives = 32/66 (48%)
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP 512
C C GF + +C D+DEC+ C NT GSF+C C G+ L PD ++C
Sbjct: 472 CRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVD 531
Query: 513 TGESPT 518
E T
Sbjct: 532 HNECAT 537
Score = 53.2 bits (122), Expect = 8e-06
Identities = 23/60 (38%), Positives = 31/60 (51%), Gaps = 1/60 (1%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T+ G C CP G+ L+E C DIDEC TC NT+G++ C C Y+
Sbjct: 1579 CVNTF-GSFQCECPPGYHLSEHTRICEDIDECSTHSSICGPGTCYNTLGNYTCVCPAEYL 1637
Score = 52.8 bits (121), Expect = 1e-05
Identities = 72/280 (25%), Positives = 105/280 (37%), Gaps = 37/280 (13%)
Query: 250 PRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEF 309
P W P EL C + C G +D + D + C PG C G
Sbjct: 2045 PGEGWGDPCEL--CPQEGSAAFQELCPFGHGAVPGPDDSRE--DVNECAENPGVCTNGVC 2100
Query: 310 KCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVR 369
DG +RC+ + +NC CS+ + C C T + G
Sbjct: 2101 VNTDGS-----FRCECPFGYSLDFTGINCVDTD--ECSVG-HPCGQGTC---TNVIGGFE 2149
Query: 370 -DCTNGEDEMNCEVSCEE-DQYTCRPQEHLMSNAFRNCVNRK--HVCDGMKDCPRG---- 421
C +G E ++CE+ D+ + P + AFR C N + ++C CP G
Sbjct: 2150 CACADGF-EPGLMMTCEDIDECSLNP----LLCAFR-CHNTEGSYLCT----CPAGYTLR 2199
Query: 422 DDEERCPLKRKCS-AEEKCEKLCITTYD--GHAACACPMGFL-LAEDKYSCRDIDECMYE 477
+D C +C+ ++ C + + G AC CP G L C D +EC +
Sbjct: 2200 EDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQ 2259
Query: 478 QDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESP 517
D + C NT GSFRC C G+ P C + P
Sbjct: 2260 PDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGP 2299
Score = 51.2 bits (117), Expect = 3e-05
Identities = 31/114 (27%), Positives = 43/114 (37%), Gaps = 6/114 (5%)
Query: 403 RNCVNRKHVCD-GMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLL 461
+N + +C G+ G D C L + A CE L G C C +G+
Sbjct: 661 KNSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENL-----RGSYRCVCNLGYEA 715
Query: 462 AEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C D+DEC + C N+ GS+ C C G+ D CK E
Sbjct: 716 GASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDE 769
Score = 51.2 bits (117), Expect = 3e-05
Identities = 41/139 (29%), Positives = 53/139 (38%), Gaps = 13/139 (9%)
Query: 385 EEDQYTCRPQEHLMS---NAFRNCVNRKHVCDGMKDCPRG--DDEERCPLKRKCSAEE-K 438
EED TC+ + S N CVN V CP G + C +CSA+
Sbjct: 2438 EEDGRTCKDLDECTSRQHNCQFLCVNT--VGAFTCRCPPGFTQHHQACFDNDECSAQPGP 2495
Query: 439 C--EKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCG 496
C C T G C C GF L + C D++EC + C C N +G +RC
Sbjct: 2496 CGAHGHCHNT-PGSFRCECHQGFTLVSSGHGCEDVNEC--DGPHRCQHGCQNQLGGYRCS 2552
Query: 497 CMTGYILRPDERSCKPTGE 515
C G+ C E
Sbjct: 2553 CPQGFTQHSQWAQCVDENE 2571
Score = 49.2 bits (112), Expect = 1e-04
Identities = 27/76 (35%), Positives = 35/76 (46%), Gaps = 2/76 (2%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T +G C C GF L+ D +C D +EC V + C N GSF C C G++
Sbjct: 505 CVNT-EGSFQCVCNAGFELSPDGKNCVDHNECATSTMCV-NGVCLNEDGSFSCLCKPGFL 562
Query: 503 LRPDERSCKPTGESPT 518
L P C E T
Sbjct: 563 LAPGGHYCMDIDECQT 578
Score = 49.2 bits (112), Expect = 1e-04
Identities = 27/72 (37%), Positives = 34/72 (47%), Gaps = 2/72 (2%)
Query: 449 GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCS-QTCSNTVGSFRCGCMTGYILRPDE 507
G C C GF++ + C D DEC VC C NT GSF C C G+ L D
Sbjct: 1866 GSYNCLCFPGFVVTHNG-DCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADG 1924
Query: 508 RSCKPTGESPTL 519
++C T E +L
Sbjct: 1925 KNCVDTNECLSL 1936
Score = 48.4 bits (110), Expect = 2e-04
Identities = 71/270 (26%), Positives = 99/270 (36%), Gaps = 38/270 (14%)
Query: 263 CAEIDFECKNTKCV--PKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKC--IP 318
CAE C N +C+ P ++C+ + D +C V C G C G C +P
Sbjct: 1366 CAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVD-ECAQGNL-CAFGSCENLP 1423
Query: 319 ERWRCDNERDCADGGDEL-----NCKPNSIRNCSLDEYTCADRRCVLK--TWLCDGVRDC 371
+RC +GG EL NC I C+ D C + C+ ++LC +D
Sbjct: 1424 GMFRC-----ICNGGYELDRGGGNC--TDINECA-DPVNCINGVCINTPGSYLCSCPQDF 1475
Query: 372 TNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKR 431
+ C + C + H ++ +C V C C L R
Sbjct: 1476 ELNPSGVGC---VDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCC-------CSLGR 1525
Query: 432 KCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSC--RDIDECMYEQDPVCSQ-TCSN 488
CE LC CP G ++ + DIDEC E +C C N
Sbjct: 1526 AWG--NPCE-LCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQ-ELPGLCQGGDCVN 1581
Query: 489 TVGSFRCGCMTGYILRPDERSCKPTGESPT 518
T GSF+C C GY L R C+ E T
Sbjct: 1582 TFGSFQCECPPGYHLSEHTRICEDIDECST 1611
Score = 48.0 bits (109), Expect = 3e-04
Identities = 24/64 (37%), Positives = 31/64 (48%), Gaps = 1/64 (1%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T G C C GF L D +C D +EC+ TC N GSFRC C G+
Sbjct: 1903 CLNTA-GSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQ 1961
Query: 503 LRPD 506
++ D
Sbjct: 1962 VQSD 1965
Score = 44.8 bits (101), Expect = 0.003
Identities = 24/69 (34%), Positives = 30/69 (43%), Gaps = 5/69 (7%)
Query: 452 ACACPMGFLLAEDKYSC-----RDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPD 506
A CP G A + +D++EC TC NTVGSF C C G+ L
Sbjct: 963 ASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQ 1022
Query: 507 ERSCKPTGE 515
ER+C E
Sbjct: 1023 ERNCTDIDE 1031
Score = 44.0 bits (99), Expect = 0.005
Identities = 23/72 (31%), Positives = 33/72 (45%), Gaps = 2/72 (2%)
Query: 455 CPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP-- 512
C GF+ +C+D+DEC +C N VGSF C C G+ L +C+
Sbjct: 232 CRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYR 291
Query: 513 TGESPTLLFSNR 524
G ++LF R
Sbjct: 292 AGACFSVLFGGR 303
Score = 41.5 bits (93), Expect = 0.027
Identities = 27/69 (39%), Positives = 31/69 (44%), Gaps = 5/69 (7%)
Query: 454 ACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQ-TCSNTVGSFRCGCMTGYILRPDERSCK 511
AC GF +C D++EC E P VC C NT GSFRC C G +L R C
Sbjct: 854 ACARGFARMTG-VTCDDVNEC--ESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCV 910
Query: 512 PTGESPTLL 520
P L
Sbjct: 911 DVRLEPCFL 919
Score = 41.1 bits (92), Expect = 0.035
Identities = 54/224 (24%), Positives = 73/224 (32%), Gaps = 24/224 (10%)
Query: 304 CNAGEFKCNDGKCIPERWRCDNERDCA-------DGGDELNCKPNSIRNCSLDEYTCADR 356
CNAG DGK + C C DG CKP + + + C D
Sbjct: 516 CNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFL--LAPGGHYCMDI 573
Query: 357 RCVLKTWLCDGVRDCTNGEDEMNCE----VSCEEDQYTCRPQEHLMSNAFRNCVNRKHVC 412
+C CTN E C+ ++ D C H+ S + K C
Sbjct: 574 DECQTPGICVNGH-CTNTEGSFRCQCLGGLAVGTDGRVC-VDTHVRSTCYGAI--EKGSC 629
Query: 413 DGMKDCPRG-DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDI 471
+ P E C E C+ LC C G + D RDI
Sbjct: 630 --ARPFPGTVTKSECCCANPDHGFGEPCQ-LCPAKNSAEFQALCSSGLGITTDG---RDI 683
Query: 472 DECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
+EC + + + C N GS+RC C GY + C E
Sbjct: 684 NECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDE 727
Score = 39.5 bits (88), Expect = 0.11
Identities = 20/73 (27%), Positives = 32/73 (43%), Gaps = 4/73 (5%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T + C C +G+ + + C D+DEC P C N G++ C C G+
Sbjct: 424 CLPTPSSYR-CECNVGYT-QDVRGECIDVDECT--SSPCHHGDCVNIPGTYHCRCYPGFQ 479
Query: 503 LRPDERSCKPTGE 515
P ++C E
Sbjct: 480 ATPTRQACVDVDE 492
Score = 39.5 bits (88), Expect = 0.11
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NGGC C+ G C+C G L DG+ CAD
Sbjct: 1159 CRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACAD 1196
Score = 37.9 bits (84), Expect = 0.33
Identities = 15/33 (45%), Positives = 18/33 (54%)
Query: 469 RDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGY 501
RD+DEC C N++GSFRC C GY
Sbjct: 2362 RDVDECRMLAHLCAHGECINSLGSFRCHCQAGY 2394
Score = 36.7 bits (81), Expect = 0.76
Identities = 15/38 (39%), Positives = 20/38 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C + C+ LC G C+CP G L +DG+TC D
Sbjct: 2409 CSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKD 2446
Score = 34.7 bits (76), Expect = 3.1
Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 2/36 (5%)
Query: 1023 NGGCSHL--CLLKPGGRSCACPIGIKLNKDGKTCAD 1056
+GG HL C+ G C C G +L+ DGK C D
Sbjct: 496 SGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVD 531
Score = 33.5 bits (73), Expect = 7.0
Identities = 14/39 (35%), Positives = 20/39 (51%), Gaps = 1/39 (2%)
Query: 1019 CGKNNGGCSH-LCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C +N G C++ +C+ G C CP G L+ G C D
Sbjct: 2088 CAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVD 2126
Score = 33.1 bits (72), Expect = 9.3
Identities = 11/26 (42%), Positives = 14/26 (53%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTG 1347
C G CS+ C +P G+ C CP G
Sbjct: 2614 CAGRRGPCSYSCANTPGGFLCGCPQG 2639
>AB177797-1|BAD16733.1| 2809|Homo sapiens fibrillin 3 protein.
Length = 2809
Score = 68.9 bits (161), Expect = 2e-10
Identities = 65/235 (27%), Positives = 86/235 (36%), Gaps = 34/235 (14%)
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNS---IRNCSLD 349
D D C P C G DG ++C C G EL K + I CSL
Sbjct: 1071 DVDECARDPLLCRGGTCTNTDGS-----YKCQ----CPPG-HELTAKGTACEDIDECSLS 1120
Query: 350 EYTCADRRCV--LKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVN 407
+ C +CV + + C + D C V E CR Q +C+N
Sbjct: 1121 DGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGC-VDINE----CRVQN---GGCDVHCIN 1172
Query: 408 RKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCE---KLC----ITTYDGHAACACPMGFL 460
+G C G P R C+ ++CE ++C T G C C GF+
Sbjct: 1173 T----EGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFM 1228
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
D +C D+DEC C NT GSF C C GY++R C E
Sbjct: 1229 ATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDE 1283
Score = 66.5 bits (155), Expect = 8e-10
Identities = 34/92 (36%), Positives = 45/92 (48%), Gaps = 3/92 (3%)
Query: 423 DEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC 482
D + C +C+ C DG +C C GFLLA + C DIDEC + +C
Sbjct: 525 DGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDEC--QTPGIC 582
Query: 483 -SQTCSNTVGSFRCGCMTGYILRPDERSCKPT 513
+ C+NT GSFRC C+ G + D R C T
Sbjct: 583 VNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDT 614
Score = 64.9 bits (151), Expect = 2e-09
Identities = 32/71 (45%), Positives = 40/71 (56%), Gaps = 3/71 (4%)
Query: 432 KCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTV 490
+CS K C LC T G C+CP G+LL ED +C+D+DEC Q C C NTV
Sbjct: 2408 ECSQVPKPCTFLCKNT-KGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHN-CQFLCVNTV 2465
Query: 491 GSFRCGCMTGY 501
G+F C C G+
Sbjct: 2466 GAFTCRCPPGF 2476
Score = 64.5 bits (150), Expect = 3e-09
Identities = 66/250 (26%), Positives = 95/250 (38%), Gaps = 36/250 (14%)
Query: 293 DEDSCPMVPGS----CNAGEFKCNDGKCIPERWRCD-NERDCADGGDELNCKPNSIRNCS 347
D+ C +PG C G D + + CD N C G E N K + + +C
Sbjct: 1208 DQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCE-NTKGSFVCHCQ 1266
Query: 348 LDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEE--DQYTCRPQEHLMSNAFR-- 403
L R+ C V +C G + SC ++CR + + F
Sbjct: 1267 LGYMV---RKGATG---CSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH 1320
Query: 404 ---NCVNRKHVCDGMKDCPRGDDEERCPLKRK-------CSAEEKCEK---LC----ITT 446
CV+++H C DC RC ++ C ++C + LC
Sbjct: 1321 DLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN 1380
Query: 447 YDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCS-QTCSNTVGSFRCGCMTGYILRP 505
G C C MGF ED +C+D+DEC Q +C+ +C N G FRC C GY L
Sbjct: 1381 APGGYRCECEMGFDPTEDHRACQDVDEC--AQGNLCAFGSCENLPGMFRCICNGGYELDR 1438
Query: 506 DERSCKPTGE 515
+C E
Sbjct: 1439 GGGNCTDINE 1448
Score = 63.3 bits (147), Expect = 8e-09
Identities = 37/104 (35%), Positives = 48/104 (46%), Gaps = 9/104 (8%)
Query: 418 CPRG----DDEERCPLKRKC-SAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDID 472
CPRG +D C +C S + C+ LC+ T G C CP GF + +C D D
Sbjct: 2431 CPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTV-GAFTCRCPPGF--TQHHQACFDND 2487
Query: 473 ECMYEQDPVCSQT-CSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
EC + P + C NT GSFRC C G+ L C+ E
Sbjct: 2488 ECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNE 2531
Score = 60.5 bits (140), Expect = 5e-08
Identities = 32/95 (33%), Positives = 38/95 (40%), Gaps = 6/95 (6%)
Query: 423 DEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC 482
DE C L C G C CP GF + C+D+DEC + P C
Sbjct: 2568 DENECALSPPTCGSASCRNTL-----GGFRCVCPSGFDFDQALGGCQDVDECAGRRGP-C 2621
Query: 483 SQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESP 517
S +C+NT G F CGC GY G SP
Sbjct: 2622 SYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSP 2656
Score = 59.7 bits (138), Expect = 9e-08
Identities = 29/73 (39%), Positives = 36/73 (49%), Gaps = 2/73 (2%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
CI + G C C G+ +C D+DEC P C+ C NT GSF C C GY+
Sbjct: 2379 CINSL-GSFRCHCQAGYTPDATATTCLDMDECSQVPKP-CTFLCKNTKGSFLCSCPRGYL 2436
Query: 503 LRPDERSCKPTGE 515
L D R+CK E
Sbjct: 2437 LEEDGRTCKDLDE 2449
Score = 59.3 bits (137), Expect = 1e-07
Identities = 35/102 (34%), Positives = 44/102 (43%), Gaps = 10/102 (9%)
Query: 415 MKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
MK+C D+ R PL C T DG C CP G L +C DIDEC
Sbjct: 1066 MKNCMDVDECARDPLL--------CRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDEC 1117
Query: 475 MYEQDPVCSQ-TCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
D +C C N +G+F+C C G+ PD + C E
Sbjct: 1118 SLS-DGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINE 1158
Score = 58.8 bits (136), Expect = 2e-07
Identities = 56/221 (25%), Positives = 78/221 (35%), Gaps = 21/221 (9%)
Query: 307 GEFKCND-GKCIPERWRCDNERDCAD--GGDELNCKPNSIRNCSLDEYTCADR-RCVLKT 362
G C+D +C CD+ C + G C P + D + C D CV +
Sbjct: 1274 GATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVG----DGFECHDLDECVSQE 1329
Query: 363 WLCDGVRDCTN--GEDEMNCEVSCEEDQYTCRPQEHLMSNAFR----NCVNRK--HVCDG 414
C DC N G C D + C ++ N C+N + C+
Sbjct: 1330 HRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCEC 1389
Query: 415 MKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
+D C +C+ C G C C G+ L +C DI+EC
Sbjct: 1390 EMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINEC 1449
Query: 475 MYEQDPV-C-SQTCSNTVGSFRCGCMTGYILRPDERSCKPT 513
DPV C + C NT GS+ C C + L P C T
Sbjct: 1450 ---ADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDT 1487
Score = 57.6 bits (133), Expect = 4e-07
Identities = 32/95 (33%), Positives = 44/95 (46%), Gaps = 3/95 (3%)
Query: 423 DEERCPLKRKC-SAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV 481
D + C +C S C +G C CP GF + D C DIDEC E +
Sbjct: 1923 DGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDH--CIDIDECSEEPNLC 1980
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGES 516
TC+N+ GSF+C C G++L + C T +S
Sbjct: 1981 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQS 2015
Score = 56.4 bits (130), Expect = 9e-07
Identities = 27/54 (50%), Positives = 30/54 (55%), Gaps = 2/54 (3%)
Query: 449 GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGY 501
G CAC GF L + +C DIDEC D +C Q TC NT GSF C C GY
Sbjct: 1007 GSFHCACAGGFALDAQERNCTDIDECRISPD-LCGQGTCVNTPGSFECECFPGY 1059
Score = 56.4 bits (130), Expect = 9e-07
Identities = 49/190 (25%), Positives = 77/190 (40%), Gaps = 21/190 (11%)
Query: 339 KPNSIRNCSLDEYTCADRRCV--LKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEH 396
KP I C CA+ C+ + ++ C+ C G + + ++CE+ +
Sbjct: 1718 KPLDIDECGEIPAICANGICINQIGSFRCE----CPAGFNYNSILLACEDVDECGSRESP 1773
Query: 397 LMSNAFRNCVN-----RKHVCDGMKDCPRGDDEERCPLKRKC-SAEEKCEKLCITTYDGH 450
NA +C+N R G K P G C + +C C +G
Sbjct: 1774 CQQNA--DCINIPGSYRCKCTRGYKLSPGG----ACVGRNECREIPNVCSHGDCMDTEGS 1827
Query: 451 AACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSC 510
C C GF + D+ C DIDEC ++ P + TC N +GS+ C C G+++ C
Sbjct: 1828 YMCLCHRGFQASADQTLCMDIDEC--DRQPCGNGTCKNIIGSYNCLCFPGFVV-THNGDC 1884
Query: 511 KPTGESPTLL 520
E TL+
Sbjct: 1885 VDFDECTTLV 1894
Score = 54.8 bits (126), Expect = 3e-06
Identities = 68/259 (26%), Positives = 98/259 (37%), Gaps = 34/259 (13%)
Query: 275 CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGD 334
C P G + C D D C PG C G +G +RC A G D
Sbjct: 557 CKPGFLLAPGGHYC---MDIDEC-QTPGICVNGHCTNTEGS-----FRCQCLGGLAVGTD 607
Query: 335 ELNCKPNSIRN-C--SLDEYTCADR--RCVLKTWLCDGVRDCTNGEDEMNCEV-SCEEDQ 388
C +R+ C ++++ +CA V K+ C D GE C + E Q
Sbjct: 608 GRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKNSAEFQ 667
Query: 389 YTCRPQEHLMSNA--FRNCVNRKHVC-DGMKDCPRGDDEERCPLK-------RKCSAEEK 438
C + ++ C VC +G+ + RG C L + C+ ++
Sbjct: 668 ALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDE 727
Query: 439 C---EKLCITTY----DGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVG 491
C LC + G +C+CP GF +D C+D+DEC+ P S C N G
Sbjct: 728 CALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECL--SSPCVSGVCRNLAG 785
Query: 492 SFRCGCMTGYILRPDERSC 510
S+ C C G L P C
Sbjct: 786 SYTCKCGPGSRLDPSGTFC 804
Score = 54.4 bits (125), Expect = 4e-06
Identities = 24/75 (32%), Positives = 34/75 (45%), Gaps = 1/75 (1%)
Query: 427 CPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTC 486
C +C +C+ C G+ C+CP GF C D +EC S +C
Sbjct: 2526 CEDVNECDGPHRCQHGCQNQLGGYR-CSCPQGFTQHSQWAQCVDENECALSPPTCGSASC 2584
Query: 487 SNTVGSFRCGCMTGY 501
NT+G FRC C +G+
Sbjct: 2585 RNTLGGFRCVCPSGF 2599
Score = 53.2 bits (122), Expect = 8e-06
Identities = 24/66 (36%), Positives = 32/66 (48%)
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP 512
C C GF + +C D+DEC+ C NT GSF+C C G+ L PD ++C
Sbjct: 472 CQCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVD 531
Query: 513 TGESPT 518
E T
Sbjct: 532 HNECAT 537
Score = 53.2 bits (122), Expect = 8e-06
Identities = 23/60 (38%), Positives = 31/60 (51%), Gaps = 1/60 (1%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T+ G C CP G+ L+E C DIDEC TC NT+G++ C C Y+
Sbjct: 1579 CVNTF-GSFQCECPPGYHLSEHTRICEDIDECSTHSSICGPGTCYNTLGNYTCVCPAEYL 1637
Score = 52.8 bits (121), Expect = 1e-05
Identities = 72/280 (25%), Positives = 105/280 (37%), Gaps = 37/280 (13%)
Query: 250 PRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEF 309
P W P EL C + C G +D + D + C PG C G
Sbjct: 2045 PGEGWGDPCEL--CPQEGSAAFQELCPFGHGAVPGPDDSRE--DVNECAENPGVCTNGVC 2100
Query: 310 KCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVR 369
DG +RC+ + +NC CS+ + C C T + G
Sbjct: 2101 VNTDGS-----FRCECPFGYSLDFTGINCVDTD--ECSVG-HPCGQGTC---TNVIGGFE 2149
Query: 370 -DCTNGEDEMNCEVSCEE-DQYTCRPQEHLMSNAFRNCVNRK--HVCDGMKDCPRG---- 421
C +G E ++CE+ D+ + P + AFR C N + ++C CP G
Sbjct: 2150 CACADGF-EPGLMMTCEDIDECSLNP----LLCAFR-CHNTEGSYLCT----CPAGYTLR 2199
Query: 422 DDEERCPLKRKCS-AEEKCEKLCITTYD--GHAACACPMGFL-LAEDKYSCRDIDECMYE 477
+D C +C+ ++ C + + G AC CP G L C D +EC +
Sbjct: 2200 EDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQ 2259
Query: 478 QDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESP 517
D + C NT GSFRC C G+ P C + P
Sbjct: 2260 PDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGP 2299
Score = 51.2 bits (117), Expect = 3e-05
Identities = 31/114 (27%), Positives = 43/114 (37%), Gaps = 6/114 (5%)
Query: 403 RNCVNRKHVCD-GMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLL 461
+N + +C G+ G D C L + A CE L G C C +G+
Sbjct: 661 KNSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENL-----RGSYRCVCNLGYEA 715
Query: 462 AEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C D+DEC + C N+ GS+ C C G+ D CK E
Sbjct: 716 GASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDE 769
Score = 51.2 bits (117), Expect = 3e-05
Identities = 41/139 (29%), Positives = 53/139 (38%), Gaps = 13/139 (9%)
Query: 385 EEDQYTCRPQEHLMS---NAFRNCVNRKHVCDGMKDCPRG--DDEERCPLKRKCSAEE-K 438
EED TC+ + S N CVN V CP G + C +CSA+
Sbjct: 2438 EEDGRTCKDLDECTSRQHNCQFLCVNT--VGAFTCRCPPGFTQHHQACFDNDECSAQPGP 2495
Query: 439 C--EKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCG 496
C C T G C C GF L + C D++EC + C C N +G +RC
Sbjct: 2496 CGAHGHCHNT-PGSFRCECHQGFTLVSSGHGCEDVNEC--DGPHRCQHGCQNQLGGYRCS 2552
Query: 497 CMTGYILRPDERSCKPTGE 515
C G+ C E
Sbjct: 2553 CPQGFTQHSQWAQCVDENE 2571
Score = 49.2 bits (112), Expect = 1e-04
Identities = 27/76 (35%), Positives = 35/76 (46%), Gaps = 2/76 (2%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T +G C C GF L+ D +C D +EC V + C N GSF C C G++
Sbjct: 505 CVNT-EGSFQCVCNAGFELSPDGKNCVDHNECATSTMCV-NGVCLNEDGSFSCLCKPGFL 562
Query: 503 LRPDERSCKPTGESPT 518
L P C E T
Sbjct: 563 LAPGGHYCMDIDECQT 578
Score = 49.2 bits (112), Expect = 1e-04
Identities = 27/72 (37%), Positives = 34/72 (47%), Gaps = 2/72 (2%)
Query: 449 GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCS-QTCSNTVGSFRCGCMTGYILRPDE 507
G C C GF++ + C D DEC VC C NT GSF C C G+ L D
Sbjct: 1866 GSYNCLCFPGFVVTHNG-DCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADG 1924
Query: 508 RSCKPTGESPTL 519
++C T E +L
Sbjct: 1925 KNCVDTNECLSL 1936
Score = 48.4 bits (110), Expect = 2e-04
Identities = 71/270 (26%), Positives = 99/270 (36%), Gaps = 38/270 (14%)
Query: 263 CAEIDFECKNTKCV--PKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKC--IP 318
CAE C N +C+ P ++C+ + D +C V C G C G C +P
Sbjct: 1366 CAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVD-ECAQGNL-CAFGSCENLP 1423
Query: 319 ERWRCDNERDCADGGDEL-----NCKPNSIRNCSLDEYTCADRRCVLK--TWLCDGVRDC 371
+RC +GG EL NC I C+ D C + C+ ++LC +D
Sbjct: 1424 GMFRC-----ICNGGYELDRGGGNC--TDINECA-DPVNCINGVCINTPGSYLCSCPQDF 1475
Query: 372 TNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKR 431
+ C + C + H ++ +C V C C L R
Sbjct: 1476 ELNPSGVGC---VDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCC-------CSLGR 1525
Query: 432 KCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSC--RDIDECMYEQDPVCSQ-TCSN 488
CE LC CP G ++ + DIDEC E +C C N
Sbjct: 1526 AWG--NPCE-LCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQ-ELPGLCQGGDCVN 1581
Query: 489 TVGSFRCGCMTGYILRPDERSCKPTGESPT 518
T GSF+C C GY L R C+ E T
Sbjct: 1582 TFGSFQCECPPGYHLSEHTRICEDIDECST 1611
Score = 48.0 bits (109), Expect = 3e-04
Identities = 24/64 (37%), Positives = 31/64 (48%), Gaps = 1/64 (1%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T G C C GF L D +C D +EC+ TC N GSFRC C G+
Sbjct: 1903 CLNTA-GSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQ 1961
Query: 503 LRPD 506
++ D
Sbjct: 1962 VQSD 1965
Score = 44.8 bits (101), Expect = 0.003
Identities = 24/69 (34%), Positives = 30/69 (43%), Gaps = 5/69 (7%)
Query: 452 ACACPMGFLLAEDKYSC-----RDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPD 506
A CP G A + +D++EC TC NTVGSF C C G+ L
Sbjct: 963 ASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQ 1022
Query: 507 ERSCKPTGE 515
ER+C E
Sbjct: 1023 ERNCTDIDE 1031
Score = 44.0 bits (99), Expect = 0.005
Identities = 23/72 (31%), Positives = 33/72 (45%), Gaps = 2/72 (2%)
Query: 455 CPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP-- 512
C GF+ +C+D+DEC +C N VGSF C C G+ L +C+
Sbjct: 232 CRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYR 291
Query: 513 TGESPTLLFSNR 524
G ++LF R
Sbjct: 292 AGACFSVLFGGR 303
Score = 41.5 bits (93), Expect = 0.027
Identities = 27/69 (39%), Positives = 31/69 (44%), Gaps = 5/69 (7%)
Query: 454 ACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQ-TCSNTVGSFRCGCMTGYILRPDERSCK 511
AC GF +C D++EC E P VC C NT GSFRC C G +L R C
Sbjct: 854 ACARGFARMTG-VTCDDVNEC--ESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCV 910
Query: 512 PTGESPTLL 520
P L
Sbjct: 911 DVRLEPCFL 919
Score = 41.1 bits (92), Expect = 0.035
Identities = 54/224 (24%), Positives = 73/224 (32%), Gaps = 24/224 (10%)
Query: 304 CNAGEFKCNDGKCIPERWRCDNERDCA-------DGGDELNCKPNSIRNCSLDEYTCADR 356
CNAG DGK + C C DG CKP + + + C D
Sbjct: 516 CNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFL--LAPGGHYCMDI 573
Query: 357 RCVLKTWLCDGVRDCTNGEDEMNCE----VSCEEDQYTCRPQEHLMSNAFRNCVNRKHVC 412
+C CTN E C+ ++ D C H+ S + K C
Sbjct: 574 DECQTPGICVNGH-CTNTEGSFRCQCLGGLAVGTDGRVC-VDTHVRSTCYGAI--EKGSC 629
Query: 413 DGMKDCPRG-DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDI 471
+ P E C E C+ LC C G + D RDI
Sbjct: 630 --ARPFPGTVTKSECCCANPDHGFGEPCQ-LCPAKNSAEFQALCSSGLGITTDG---RDI 683
Query: 472 DECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
+EC + + + C N GS+RC C GY + C E
Sbjct: 684 NECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDE 727
Score = 39.5 bits (88), Expect = 0.11
Identities = 20/73 (27%), Positives = 32/73 (43%), Gaps = 4/73 (5%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T + C C +G+ + + C D+DEC P C N G++ C C G+
Sbjct: 424 CLPTPSSYR-CECNVGYT-QDVRGECIDVDECT--SSPCHHGDCVNIPGTYHCQCYPGFQ 479
Query: 503 LRPDERSCKPTGE 515
P ++C E
Sbjct: 480 ATPTRQACVDVDE 492
Score = 39.5 bits (88), Expect = 0.11
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NGGC C+ G C+C G L DG+ CAD
Sbjct: 1159 CRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACAD 1196
Score = 37.9 bits (84), Expect = 0.33
Identities = 15/33 (45%), Positives = 18/33 (54%)
Query: 469 RDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGY 501
RD+DEC C N++GSFRC C GY
Sbjct: 2362 RDVDECRMLAHLCAHGECINSLGSFRCHCQAGY 2394
Score = 36.7 bits (81), Expect = 0.76
Identities = 15/38 (39%), Positives = 20/38 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C + C+ LC G C+CP G L +DG+TC D
Sbjct: 2409 CSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKD 2446
Score = 34.7 bits (76), Expect = 3.1
Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 2/36 (5%)
Query: 1023 NGGCSHL--CLLKPGGRSCACPIGIKLNKDGKTCAD 1056
+GG HL C+ G C C G +L+ DGK C D
Sbjct: 496 SGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVD 531
Score = 33.5 bits (73), Expect = 7.0
Identities = 14/39 (35%), Positives = 20/39 (51%), Gaps = 1/39 (2%)
Query: 1019 CGKNNGGCSH-LCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C +N G C++ +C+ G C CP G L+ G C D
Sbjct: 2088 CAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVD 2126
Score = 33.1 bits (72), Expect = 9.3
Identities = 11/26 (42%), Positives = 14/26 (53%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTG 1347
C G CS+ C +P G+ C CP G
Sbjct: 2614 CAGRRGPCSYSCANTPGGFLCGCPQG 2639
>AB053450-1|BAB47408.2| 2816|Homo sapiens fibrillin3 protein.
Length = 2816
Score = 68.9 bits (161), Expect = 2e-10
Identities = 65/235 (27%), Positives = 86/235 (36%), Gaps = 34/235 (14%)
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNS---IRNCSLD 349
D D C P C G DG ++C C G EL K + I CSL
Sbjct: 1078 DVDECARDPLLCRGGTCTNTDGS-----YKCQ----CPPG-HELTAKGTACEDIDECSLS 1127
Query: 350 EYTCADRRCV--LKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVN 407
+ C +CV + + C + D C V E CR Q +C+N
Sbjct: 1128 DGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGC-VDINE----CRVQN---GGCDVHCIN 1179
Query: 408 RKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCE---KLC----ITTYDGHAACACPMGFL 460
+G C G P R C+ ++CE ++C T G C C GF+
Sbjct: 1180 T----EGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFM 1235
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
D +C D+DEC C NT GSF C C GY++R C E
Sbjct: 1236 ATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDE 1290
Score = 66.5 bits (155), Expect = 8e-10
Identities = 34/92 (36%), Positives = 45/92 (48%), Gaps = 3/92 (3%)
Query: 423 DEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC 482
D + C +C+ C DG +C C GFLLA + C DIDEC + +C
Sbjct: 532 DGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDEC--QTPGIC 589
Query: 483 -SQTCSNTVGSFRCGCMTGYILRPDERSCKPT 513
+ C+NT GSFRC C+ G + D R C T
Sbjct: 590 VNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDT 621
Score = 64.9 bits (151), Expect = 2e-09
Identities = 32/71 (45%), Positives = 40/71 (56%), Gaps = 3/71 (4%)
Query: 432 KCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTV 490
+CS K C LC T G C+CP G+LL ED +C+D+DEC Q C C NTV
Sbjct: 2415 ECSQVPKPCTFLCKNT-KGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHN-CQFLCVNTV 2472
Query: 491 GSFRCGCMTGY 501
G+F C C G+
Sbjct: 2473 GAFTCRCPPGF 2483
Score = 64.1 bits (149), Expect = 4e-09
Identities = 65/250 (26%), Positives = 95/250 (38%), Gaps = 36/250 (14%)
Query: 293 DEDSCPMVPGS----CNAGEFKCNDGKCIPERWRCD-NERDCADGGDELNCKPNSIRNCS 347
D+ C +PG C G D + + CD N C G E N K + + +C
Sbjct: 1215 DQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCE-NTKGSFVCHCQ 1273
Query: 348 LDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEE--DQYTCRPQEHLMSNAFR-- 403
L R+ C V +C G + SC ++CR + + F
Sbjct: 1274 LGYMV---RKGATG---CSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH 1327
Query: 404 ---NCVNRKHVCDGMKDCPRGDDEERCPLKRK-------CSAEEKCEK---LC----ITT 446
C++++H C DC RC ++ C ++C + LC
Sbjct: 1328 DLDECISQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN 1387
Query: 447 YDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCS-QTCSNTVGSFRCGCMTGYILRP 505
G C C MGF ED +C+D+DEC Q +C+ +C N G FRC C GY L
Sbjct: 1388 APGGYRCECEMGFDPTEDHRACQDVDEC--AQGNLCAFGSCENLPGMFRCICNGGYELDR 1445
Query: 506 DERSCKPTGE 515
+C E
Sbjct: 1446 GGGNCTDINE 1455
Score = 63.3 bits (147), Expect = 8e-09
Identities = 37/104 (35%), Positives = 48/104 (46%), Gaps = 9/104 (8%)
Query: 418 CPRG----DDEERCPLKRKC-SAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDID 472
CPRG +D C +C S + C+ LC+ T G C CP GF + +C D D
Sbjct: 2438 CPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTV-GAFTCRCPPGF--TQHHQACFDND 2494
Query: 473 ECMYEQDPVCSQT-CSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
EC + P + C NT GSFRC C G+ L C+ E
Sbjct: 2495 ECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNE 2538
Score = 60.5 bits (140), Expect = 5e-08
Identities = 32/95 (33%), Positives = 38/95 (40%), Gaps = 6/95 (6%)
Query: 423 DEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC 482
DE C L C G C CP GF + C+D+DEC + P C
Sbjct: 2575 DENECALSPPTCGSASCRNTL-----GGFRCVCPSGFDFDQALGGCQDVDECAGRRGP-C 2628
Query: 483 SQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESP 517
S +C+NT G F CGC GY G SP
Sbjct: 2629 SYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSP 2663
Score = 59.7 bits (138), Expect = 9e-08
Identities = 29/73 (39%), Positives = 36/73 (49%), Gaps = 2/73 (2%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
CI + G C C G+ +C D+DEC P C+ C NT GSF C C GY+
Sbjct: 2386 CINSL-GSFRCHCQAGYTPDATATTCLDMDECSQVPKP-CTFLCKNTKGSFLCSCPRGYL 2443
Query: 503 LRPDERSCKPTGE 515
L D R+CK E
Sbjct: 2444 LEEDGRTCKDLDE 2456
Score = 59.3 bits (137), Expect = 1e-07
Identities = 35/102 (34%), Positives = 44/102 (43%), Gaps = 10/102 (9%)
Query: 415 MKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
MK+C D+ R PL C T DG C CP G L +C DIDEC
Sbjct: 1073 MKNCMDVDECARDPLL--------CRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDEC 1124
Query: 475 MYEQDPVCSQ-TCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
D +C C N +G+F+C C G+ PD + C E
Sbjct: 1125 SLS-DGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINE 1165
Score = 58.4 bits (135), Expect = 2e-07
Identities = 55/221 (24%), Positives = 78/221 (35%), Gaps = 21/221 (9%)
Query: 307 GEFKCND-GKCIPERWRCDNERDCAD--GGDELNCKPNSIRNCSLDEYTCADR-RCVLKT 362
G C+D +C CD+ C + G C P + D + C D C+ +
Sbjct: 1281 GATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVG----DGFECHDLDECISQE 1336
Query: 363 WLCDGVRDCTN--GEDEMNCEVSCEEDQYTCRPQEHLMSNAFR----NCVNRK--HVCDG 414
C DC N G C D + C ++ N C+N + C+
Sbjct: 1337 HRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCEC 1396
Query: 415 MKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
+D C +C+ C G C C G+ L +C DI+EC
Sbjct: 1397 EMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINEC 1456
Query: 475 MYEQDPV-C-SQTCSNTVGSFRCGCMTGYILRPDERSCKPT 513
DPV C + C NT GS+ C C + L P C T
Sbjct: 1457 ---ADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDT 1494
Score = 57.6 bits (133), Expect = 4e-07
Identities = 32/95 (33%), Positives = 44/95 (46%), Gaps = 3/95 (3%)
Query: 423 DEERCPLKRKC-SAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV 481
D + C +C S C +G C CP GF + D C DIDEC E +
Sbjct: 1930 DGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDH--CIDIDECSEEPNLC 1987
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGES 516
TC+N+ GSF+C C G++L + C T +S
Sbjct: 1988 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQS 2022
Score = 56.4 bits (130), Expect = 9e-07
Identities = 27/54 (50%), Positives = 30/54 (55%), Gaps = 2/54 (3%)
Query: 449 GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGY 501
G CAC GF L + +C DIDEC D +C Q TC NT GSF C C GY
Sbjct: 1014 GSFHCACAGGFALDAQERNCTDIDECRISPD-LCGQGTCVNTPGSFECECFPGY 1066
Score = 54.8 bits (126), Expect = 3e-06
Identities = 68/259 (26%), Positives = 98/259 (37%), Gaps = 34/259 (13%)
Query: 275 CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGD 334
C P G + C D D C PG C G +G +RC A G D
Sbjct: 564 CKPGFLLAPGGHYC---MDIDEC-QTPGICVNGHCTNTEGS-----FRCQCLGGLAVGTD 614
Query: 335 ELNCKPNSIRN-C--SLDEYTCADR--RCVLKTWLCDGVRDCTNGEDEMNCEV-SCEEDQ 388
C +R+ C ++++ +CA V K+ C D GE C + E Q
Sbjct: 615 GRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKNSAEFQ 674
Query: 389 YTCRPQEHLMSNA--FRNCVNRKHVC-DGMKDCPRGDDEERCPLK-------RKCSAEEK 438
C + ++ C VC +G+ + RG C L + C+ ++
Sbjct: 675 ALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDE 734
Query: 439 C---EKLCITTY----DGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVG 491
C LC + G +C+CP GF +D C+D+DEC+ P S C N G
Sbjct: 735 CALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECL--SSPCVSGVCRNLAG 792
Query: 492 SFRCGCMTGYILRPDERSC 510
S+ C C G L P C
Sbjct: 793 SYTCKCGPGSRLDPSGTFC 811
Score = 54.4 bits (125), Expect = 4e-06
Identities = 24/75 (32%), Positives = 34/75 (45%), Gaps = 1/75 (1%)
Query: 427 CPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTC 486
C +C +C+ C G+ C+CP GF C D +EC S +C
Sbjct: 2533 CEDVNECDGPHRCQHGCQNQLGGYR-CSCPQGFTQHSQWAQCVDENECALSPPTCGSASC 2591
Query: 487 SNTVGSFRCGCMTGY 501
NT+G FRC C +G+
Sbjct: 2592 RNTLGGFRCVCPSGF 2606
Score = 53.2 bits (122), Expect = 8e-06
Identities = 24/66 (36%), Positives = 32/66 (48%)
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP 512
C C GF + +C D+DEC+ C NT GSF+C C G+ L PD ++C
Sbjct: 479 CRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVD 538
Query: 513 TGESPT 518
E T
Sbjct: 539 HNECAT 544
Score = 53.2 bits (122), Expect = 8e-06
Identities = 27/66 (40%), Positives = 32/66 (48%), Gaps = 4/66 (6%)
Query: 442 LCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQT--CSNTVGSFRCGCMT 499
+CI G C CP GF +C D+DEC + P C Q C N GS+RC C
Sbjct: 1743 ICINQI-GSFRCECPAGFNYNSILLACEDVDECGSRESP-CQQNADCINIPGSYRCKCTR 1800
Query: 500 GYILRP 505
GY L P
Sbjct: 1801 GYKLSP 1806
Score = 52.8 bits (121), Expect = 1e-05
Identities = 23/60 (38%), Positives = 31/60 (51%), Gaps = 1/60 (1%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T+ G C CP G+ L+E C DIDEC TC NT+G++ C C Y+
Sbjct: 1586 CVNTF-GSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYL 1644
Score = 52.8 bits (121), Expect = 1e-05
Identities = 72/280 (25%), Positives = 105/280 (37%), Gaps = 37/280 (13%)
Query: 250 PRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEF 309
P W P EL C + C G +D + D + C PG C G
Sbjct: 2052 PGEGWGDPCEL--CPQEGSAAFQELCPFGHGAVPGPDDSRE--DVNECAENPGVCTNGVC 2107
Query: 310 KCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVR 369
DG +RC+ + +NC CS+ + C C T + G
Sbjct: 2108 VNTDGS-----FRCECPFGYSLDFTGINCVDTD--ECSVG-HPCGQGTC---TNVIGGFE 2156
Query: 370 -DCTNGEDEMNCEVSCEE-DQYTCRPQEHLMSNAFRNCVNRK--HVCDGMKDCPRG---- 421
C +G E ++CE+ D+ + P + AFR C N + ++C CP G
Sbjct: 2157 CACADGF-EPGLMMTCEDIDECSLNP----LLCAFR-CHNTEGSYLCT----CPAGYTLR 2206
Query: 422 DDEERCPLKRKCS-AEEKCEKLCITTYD--GHAACACPMGFL-LAEDKYSCRDIDECMYE 477
+D C +C+ ++ C + + G AC CP G L C D +EC +
Sbjct: 2207 EDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQ 2266
Query: 478 QDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESP 517
D + C NT GSFRC C G+ P C + P
Sbjct: 2267 PDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGP 2306
Score = 51.2 bits (117), Expect = 3e-05
Identities = 31/114 (27%), Positives = 43/114 (37%), Gaps = 6/114 (5%)
Query: 403 RNCVNRKHVCD-GMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLL 461
+N + +C G+ G D C L + A CE L G C C +G+
Sbjct: 668 KNSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENL-----RGSYRCVCNLGYEA 722
Query: 462 AEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C D+DEC + C N+ GS+ C C G+ D CK E
Sbjct: 723 GASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDE 776
Score = 51.2 bits (117), Expect = 3e-05
Identities = 41/139 (29%), Positives = 53/139 (38%), Gaps = 13/139 (9%)
Query: 385 EEDQYTCRPQEHLMS---NAFRNCVNRKHVCDGMKDCPRG--DDEERCPLKRKCSAEE-K 438
EED TC+ + S N CVN V CP G + C +CSA+
Sbjct: 2445 EEDGRTCKDLDECTSRQHNCQFLCVNT--VGAFTCRCPPGFTQHHQACFDNDECSAQPGP 2502
Query: 439 C--EKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCG 496
C C T G C C GF L + C D++EC + C C N +G +RC
Sbjct: 2503 CGAHGHCHNT-PGSFRCECHQGFTLVSSGHGCEDVNEC--DGPHRCQHGCQNQLGGYRCS 2559
Query: 497 CMTGYILRPDERSCKPTGE 515
C G+ C E
Sbjct: 2560 CPQGFTQHSQWAQCVDENE 2578
Score = 49.6 bits (113), Expect = 1e-04
Identities = 36/133 (27%), Positives = 52/133 (39%), Gaps = 3/133 (2%)
Query: 388 QYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTY 447
Q CR ++ S+ ++C + D+ C +C + C
Sbjct: 1813 QNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECD-RQPCGNGTCKNI 1871
Query: 448 DGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCS-QTCSNTVGSFRCGCMTGYILRPD 506
G C C GF++ + C D DEC VC C NT GSF C C G+ L D
Sbjct: 1872 IGSYNCLCFPGFVVTHNG-DCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTAD 1930
Query: 507 ERSCKPTGESPTL 519
++C T E +L
Sbjct: 1931 GKNCVDTNECLSL 1943
Score = 49.2 bits (112), Expect = 1e-04
Identities = 27/76 (35%), Positives = 35/76 (46%), Gaps = 2/76 (2%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T +G C C GF L+ D +C D +EC V + C N GSF C C G++
Sbjct: 512 CVNT-EGSFQCVCNAGFELSPDGKNCVDHNECATSTMCV-NGVCLNEDGSFSCLCKPGFL 569
Query: 503 LRPDERSCKPTGESPT 518
L P C E T
Sbjct: 570 LAPGGHYCMDIDECQT 585
Score = 48.4 bits (110), Expect = 2e-04
Identities = 71/270 (26%), Positives = 99/270 (36%), Gaps = 38/270 (14%)
Query: 263 CAEIDFECKNTKCV--PKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKC--IP 318
CAE C N +C+ P ++C+ + D +C V C G C G C +P
Sbjct: 1373 CAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVD-ECAQGNL-CAFGSCENLP 1430
Query: 319 ERWRCDNERDCADGGDEL-----NCKPNSIRNCSLDEYTCADRRCVLK--TWLCDGVRDC 371
+RC +GG EL NC I C+ D C + C+ ++LC +D
Sbjct: 1431 GMFRC-----ICNGGYELDRGGGNC--TDINECA-DPVNCINGVCINTPGSYLCSCPQDF 1482
Query: 372 TNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKR 431
+ C + C + H ++ +C V C C L R
Sbjct: 1483 ELNPSGVGC---VDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCC-------CSLGR 1532
Query: 432 KCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSC--RDIDECMYEQDPVCSQ-TCSN 488
CE LC CP G ++ + DIDEC E +C C N
Sbjct: 1533 AWG--NPCE-LCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQ-ELPGLCQGGDCVN 1588
Query: 489 TVGSFRCGCMTGYILRPDERSCKPTGESPT 518
T GSF+C C GY L R C+ E T
Sbjct: 1589 TFGSFQCECPPGYHLSEHTRICEDIDECST 1618
Score = 48.0 bits (109), Expect = 3e-04
Identities = 24/64 (37%), Positives = 31/64 (48%), Gaps = 1/64 (1%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T G C C GF L D +C D +EC+ TC N GSFRC C G+
Sbjct: 1910 CLNTA-GSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQ 1968
Query: 503 LRPD 506
++ D
Sbjct: 1969 VQSD 1972
Score = 44.8 bits (101), Expect = 0.003
Identities = 24/69 (34%), Positives = 30/69 (43%), Gaps = 5/69 (7%)
Query: 452 ACACPMGFLLAEDKYSC-----RDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPD 506
A CP G A + +D++EC TC NTVGSF C C G+ L
Sbjct: 970 ASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQ 1029
Query: 507 ERSCKPTGE 515
ER+C E
Sbjct: 1030 ERNCTDIDE 1038
Score = 44.0 bits (99), Expect = 0.005
Identities = 23/72 (31%), Positives = 33/72 (45%), Gaps = 2/72 (2%)
Query: 455 CPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP-- 512
C GF+ +C+D+DEC +C N VGSF C C G+ L +C+
Sbjct: 239 CRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYR 298
Query: 513 TGESPTLLFSNR 524
G ++LF R
Sbjct: 299 AGACFSVLFGGR 310
Score = 41.5 bits (93), Expect = 0.027
Identities = 27/69 (39%), Positives = 31/69 (44%), Gaps = 5/69 (7%)
Query: 454 ACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQ-TCSNTVGSFRCGCMTGYILRPDERSCK 511
AC GF +C D++EC E P VC C NT GSFRC C G +L R C
Sbjct: 861 ACARGFARMTG-VTCDDVNEC--ESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCV 917
Query: 512 PTGESPTLL 520
P L
Sbjct: 918 DVRLEPCFL 926
Score = 41.1 bits (92), Expect = 0.035
Identities = 54/224 (24%), Positives = 73/224 (32%), Gaps = 24/224 (10%)
Query: 304 CNAGEFKCNDGKCIPERWRCDNERDCA-------DGGDELNCKPNSIRNCSLDEYTCADR 356
CNAG DGK + C C DG CKP + + + C D
Sbjct: 523 CNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFL--LAPGGHYCMDI 580
Query: 357 RCVLKTWLCDGVRDCTNGEDEMNCE----VSCEEDQYTCRPQEHLMSNAFRNCVNRKHVC 412
+C CTN E C+ ++ D C H+ S + K C
Sbjct: 581 DECQTPGICVNGH-CTNTEGSFRCQCLGGLAVGTDGRVC-VDTHVRSTCYGAI--EKGSC 636
Query: 413 DGMKDCPRG-DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDI 471
+ P E C E C+ LC C G + D RDI
Sbjct: 637 --ARPFPGTVTKSECCCANPDHGFGEPCQ-LCPAKNSAEFQALCSSGLGITTDG---RDI 690
Query: 472 DECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
+EC + + + C N GS+RC C GY + C E
Sbjct: 691 NECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDE 734
Score = 39.5 bits (88), Expect = 0.11
Identities = 20/73 (27%), Positives = 32/73 (43%), Gaps = 4/73 (5%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T + C C +G+ + + C D+DEC P C N G++ C C G+
Sbjct: 431 CLPTPSSYR-CECNVGYT-QDVRGECIDVDECT--SSPCHHGDCVNIPGTYHCRCYPGFQ 486
Query: 503 LRPDERSCKPTGE 515
P ++C E
Sbjct: 487 ATPTRQACVDVDE 499
Score = 39.5 bits (88), Expect = 0.11
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NGGC C+ G C+C G L DG+ CAD
Sbjct: 1166 CRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACAD 1203
Score = 39.1 bits (87), Expect = 0.14
Identities = 64/233 (27%), Positives = 83/233 (35%), Gaps = 39/233 (16%)
Query: 293 DEDSCPMVPGSCNAGE----FKCNDGKCIPERWRCDNERDCADGGDELN-----CKPNSI 343
D D C +PG C G+ F +C P ++ R C D DE + C P +
Sbjct: 1570 DIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDI-DECSTHSGICGPGTC 1628
Query: 344 RNCSLDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFR 403
N +L YTC C + +G +C +M V TC Q L N
Sbjct: 1629 YN-TLGNYTCV---CPAEYLQVNGGNNCM----DMRKSVCFRHYNGTC--QNELAFN--- 1675
Query: 404 NCVNRKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAE 463
V RK C C + R C A C Y P GFL
Sbjct: 1676 --VTRKMCC-----CSYNIGQA---WNRPCEA---CPTPISPDYQILCGNQAP-GFLTDI 1721
Query: 464 DKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
DIDEC E +C+ C N +GSFRC C G+ +C+ E
Sbjct: 1722 HTGKPLDIDECG-EIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDE 1773
Score = 37.9 bits (84), Expect = 0.33
Identities = 15/33 (45%), Positives = 18/33 (54%)
Query: 469 RDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGY 501
RD+DEC C N++GSFRC C GY
Sbjct: 2369 RDVDECRMLAHLCAHGECINSLGSFRCHCQAGY 2401
Score = 36.7 bits (81), Expect = 0.76
Identities = 15/38 (39%), Positives = 20/38 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C + C+ LC G C+CP G L +DG+TC D
Sbjct: 2416 CSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKD 2453
Score = 36.3 bits (80), Expect = 1.00
Identities = 27/85 (31%), Positives = 37/85 (43%), Gaps = 6/85 (7%)
Query: 434 SAEEKCEKL--CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTV 490
S E C++ CI G C C G+ L+ +C +EC E VCS C +T
Sbjct: 1776 SRESPCQQNADCINI-PGSYRCKCTRGYKLSPGG-ACVGQNECR-EIPNVCSHGDCMDTE 1832
Query: 491 GSFRCGCMTGYILRPDERSCKPTGE 515
GS+ C C G+ D+ C E
Sbjct: 1833 GSYMCLCHRGFQASADQTLCMDIDE 1857
Score = 34.7 bits (76), Expect = 3.1
Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 2/36 (5%)
Query: 1023 NGGCSHL--CLLKPGGRSCACPIGIKLNKDGKTCAD 1056
+GG HL C+ G C C G +L+ DGK C D
Sbjct: 503 SGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVD 538
Score = 33.5 bits (73), Expect = 7.0
Identities = 14/39 (35%), Positives = 20/39 (51%), Gaps = 1/39 (2%)
Query: 1019 CGKNNGGCSH-LCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C +N G C++ +C+ G C CP G L+ G C D
Sbjct: 2095 CAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVD 2133
Score = 33.1 bits (72), Expect = 9.3
Identities = 11/26 (42%), Positives = 14/26 (53%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTG 1347
C G CS+ C +P G+ C CP G
Sbjct: 2621 CAGRRGPCSYSCANTPGGFLCGCPQG 2646
>AK027775-1|BAB55358.1| 537|Homo sapiens protein ( Homo sapiens
cDNA FLJ14869 fis, clone PLACE1002474, moderately
similar to Mus musculus matrilin-2 precursor mRNA. ).
Length = 537
Score = 68.1 bits (159), Expect = 3e-10
Identities = 55/203 (27%), Positives = 80/203 (39%), Gaps = 15/203 (7%)
Query: 326 ERDCADGGDELNCKPNSIRNCSLDEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVS- 383
E+ C + D C+ + + D TC+ C+L C+ C N + C+
Sbjct: 36 EQLCLNTEDSFVCQCSEGFLINEDLMTCSRVDYCLLSDHGCE--YSCVNMDRSFACQCPE 93
Query: 384 ---CEEDQYTCRPQEHLM---SNAFRNCVNRKH--VCDGMKDCPRGDDEERCPLKRKCSA 435
D TC + +CV+ + VC + +D + C K C A
Sbjct: 94 GHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQA 153
Query: 436 -EEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFR 494
+ CE +C+ + D + C C GF LAED CR D C C C N S+
Sbjct: 154 IDHGCEHICVNSDDSYT-CECLEGFRLAEDGKRCRRKDVCKSTHHG-CEHICVNNGNSYI 211
Query: 495 CGCMTGYILRPDERSCKPTGESP 517
C C G++L D R CK E P
Sbjct: 212 CKCSEGFVLAEDGRRCKKCTEGP 234
Score = 62.1 bits (144), Expect = 2e-08
Identities = 37/122 (30%), Positives = 53/122 (43%), Gaps = 4/122 (3%)
Query: 391 CRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCS-AEEKCEKLCITTYDG 449
C Q+H N + VC + +D C C ++ CE C+ D
Sbjct: 28 CAQQDHGCEQLCLNTED-SFVCQCSEGFLINEDLMTCSRVDYCLLSDHGCEYSCVNM-DR 85
Query: 450 HAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERS 509
AC CP G +L D +C +D C D C +C ++ SF C C GYILR D ++
Sbjct: 86 SFACQCPEGHVLRSDGKTCAKLDSCALG-DHGCEHSCVSSEDSFVCQCFEGYILREDGKT 144
Query: 510 CK 511
C+
Sbjct: 145 CR 146
Score = 50.0 bits (114), Expect = 8e-05
Identities = 21/58 (36%), Positives = 30/58 (51%), Gaps = 1/58 (1%)
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSC 510
C C G+ L + +C +D C +QD C Q C NT SF C C G+++ D +C
Sbjct: 7 CRCHRGYTLDPNGKTCSRVDHCA-QQDHGCEQLCLNTEDSFVCQCSEGFLINEDLMTC 63
Score = 38.7 bits (86), Expect = 0.19
Identities = 20/54 (37%), Positives = 27/54 (50%), Gaps = 4/54 (7%)
Query: 1014 RRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDG---KTCADGPINYLIF 1064
RR C + GC H+C+ C C G L +DG K C +GPI+ L+F
Sbjct: 187 RRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPID-LVF 239
Score = 37.5 bits (83), Expect = 0.43
Identities = 18/49 (36%), Positives = 24/49 (48%)
Query: 1007 NKDTGAKRRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCA 1055
N+D R C ++ GC + C+ +C CP G L DGKTCA
Sbjct: 57 NEDLMTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCA 105
Score = 37.1 bits (82), Expect = 0.57
Identities = 11/25 (44%), Positives = 17/25 (68%)
Query: 1631 CKESNGGCSHLCLFRGHEYICACPD 1655
CK ++ GC H+C+ G+ YIC C +
Sbjct: 192 CKSTHHGCEHICVNNGNSYICKCSE 216
Score = 36.7 bits (81), Expect = 0.76
Identities = 18/59 (30%), Positives = 29/59 (49%), Gaps = 3/59 (5%)
Query: 1319 ENACGTDNGGCSHLCLRSPLGYTCACPTGMPFEKSTTDQTPKKCKSHPEEFLIFATRGS 1377
++ C + + GC H+C+ + Y C C G F + + KKC P + L+F GS
Sbjct: 189 KDVCKSTHHGCEHICVNNGNSYICKCSEG--FVLAEDGRRCKKCTEGPID-LVFVIDGS 244
Score = 36.3 bits (80), Expect = 1.00
Identities = 15/41 (36%), Positives = 21/41 (51%)
Query: 1014 RRTLGCGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
RR C + GC H+C+ +C C G +L +DGK C
Sbjct: 146 RRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRC 186
Score = 34.7 bits (76), Expect = 3.1
Identities = 14/36 (38%), Positives = 17/36 (47%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTC 1054
C + GC H C+ C C G L +DGKTC
Sbjct: 110 CALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTC 145
Score = 34.3 bits (75), Expect = 4.0
Identities = 17/59 (28%), Positives = 29/59 (49%), Gaps = 3/59 (5%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCADGPINY-LIFAHRVDIRVISLD 1076
C + + GC LCL C C G +N+D TC+ ++Y L+ H + +++D
Sbjct: 28 CAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLMTCS--RVDYCLLSDHGCEYSCVNMD 84
>AF054502-1|AAC39882.1| 669|Homo sapiens latent transforming growth
factor-beta binding protein 4 protein.
Length = 669
Score = 68.1 bits (159), Expect = 3e-10
Identities = 41/109 (37%), Positives = 50/109 (45%), Gaps = 7/109 (6%)
Query: 414 GMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDE 473
G + PRG C +CS E+ C+ T DG C CP G D SC D+DE
Sbjct: 131 GYRPGPRGAS---CLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDE 187
Query: 474 CMYEQDPVC-SQTCSNTVGSFRC--GCMTGYILRPDERSCKPTGESPTL 519
C +C SQ C N+ GS+RC C GY P E +C E TL
Sbjct: 188 CRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGP-EGTCDDVNECETL 235
Score = 58.4 bits (135), Expect = 2e-07
Identities = 31/73 (42%), Positives = 37/73 (50%), Gaps = 2/73 (2%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T DG AC C G+ SC D+DEC E+D S C+NT GSF C C G+
Sbjct: 117 CLNT-DGSFACTCAPGYRPGPRGASCLDVDECS-EEDLCQSGICTNTDGSFECICPPGHR 174
Query: 503 LRPDERSCKPTGE 515
PD SC E
Sbjct: 175 AGPDLASCLDVDE 187
Score = 54.0 bits (124), Expect = 5e-06
Identities = 32/99 (32%), Positives = 50/99 (50%), Gaps = 9/99 (9%)
Query: 423 DEERCPLKRKCSAEEKCEK-LCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV 481
D + C L R ++ C+ +C+ T G++ C C G+ + C D DEC +++P
Sbjct: 390 DVDECQLFR----DQVCKSGVCVNTAPGYS-CYCSNGYYYHTQRLECIDNDECA-DEEPA 443
Query: 482 CSQ-TCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTL 519
C C NTVGS+ C C +L +R C + ES +L
Sbjct: 444 CEGGRCVNTVGSYHCTCEPPLVLDGSQRRC-VSNESQSL 481
Score = 47.6 bits (108), Expect = 4e-04
Identities = 27/81 (33%), Positives = 35/81 (43%), Gaps = 8/81 (9%)
Query: 422 DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV 481
+D + C C +E C+ + ACP G L + C D+DEC P
Sbjct: 16 EDVDECENHLACPGQE-----CVNSPGSFQCRACPSGHHLHRGR--CTDVDECSSGAPPC 68
Query: 482 CSQT-CSNTVGSFRCGCMTGY 501
C+NT GSFRC C GY
Sbjct: 69 GPHGHCTNTEGSFRCSCAPGY 89
Score = 41.5 bits (93), Expect = 0.027
Identities = 22/67 (32%), Positives = 28/67 (41%), Gaps = 2/67 (2%)
Query: 446 TYDGHAACACPMGFLLAEDKYSCR-DIDECMYEQDPVC-SQTCSNTVGSFRCGCMTGYIL 503
T + + C G+L S R D+DEC +D VC S C NT + C C GY
Sbjct: 365 TAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYY 424
Query: 504 RPDERSC 510
C
Sbjct: 425 HTQRLEC 431
Score = 37.1 bits (82), Expect = 0.57
Identities = 21/50 (42%), Positives = 26/50 (52%), Gaps = 4/50 (8%)
Query: 456 PMGFLLAEDKYSCRDIDECMYEQDPVC-SQTCSNTVGSFRC-GCMTGYIL 503
PMGF C D+DEC E C Q C N+ GSF+C C +G+ L
Sbjct: 3 PMGFQPNAAGSECEDVDEC--ENHLACPGQECVNSPGSFQCRACPSGHHL 50
>AK074499-1|BAC11024.1| 636|Homo sapiens protein ( Homo sapiens
cDNA FLJ90018 fis, clone HEMBA1000732, highly similar to
Homo sapiens mRNA for latent transforming growth
factor-beta ).
Length = 636
Score = 67.7 bits (158), Expect = 4e-10
Identities = 38/97 (39%), Positives = 46/97 (47%), Gaps = 5/97 (5%)
Query: 427 CPLK-RKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC-SQ 484
CP +CS E+ C+ T DG C CP G D SC D+DEC +C SQ
Sbjct: 15 CPADVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCRSQ 74
Query: 485 TCSNTVGSFRC--GCMTGYILRPDERSCKPTGESPTL 519
C N+ GS+RC C GY P E +C E TL
Sbjct: 75 RCENSPGSYRCVRDCDPGYHAGP-EGTCDDVNECETL 110
Score = 54.0 bits (124), Expect = 5e-06
Identities = 32/99 (32%), Positives = 50/99 (50%), Gaps = 9/99 (9%)
Query: 423 DEERCPLKRKCSAEEKCEK-LCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV 481
D + C L R ++ C+ +C+ T G++ C C G+ + C D DEC +++P
Sbjct: 265 DVDECQLFR----DQVCKSGVCVNTAPGYS-CYCSNGYYYHTQRLECIDNDECA-DEEPA 318
Query: 482 CSQ-TCSNTVGSFRCGCMTGYILRPDERSCKPTGESPTL 519
C C NTVGS+ C C +L +R C + ES +L
Sbjct: 319 CEGGRCVNTVGSYHCTCEPPLVLDGSQRRC-VSNESQSL 356
Score = 46.4 bits (105), Expect = 0.001
Identities = 27/85 (31%), Positives = 39/85 (45%), Gaps = 5/85 (5%)
Query: 432 KCSAEEKCEK-LCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQ--DPVC-SQTCS 487
+C + C C+ +G C C G+ L + +C DI+EC + P+C + C
Sbjct: 548 ECGILDGCTNGRCVRVPEGFT-CRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCL 606
Query: 488 NTVGSFRCGCMTGYILRPDERSCKP 512
NT GSFRC C G+ C P
Sbjct: 607 NTDGSFRCICRPGFAPTHQPHHCAP 631
Score = 41.5 bits (93), Expect = 0.027
Identities = 22/67 (32%), Positives = 28/67 (41%), Gaps = 2/67 (2%)
Query: 446 TYDGHAACACPMGFLLAEDKYSCR-DIDECMYEQDPVC-SQTCSNTVGSFRCGCMTGYIL 503
T + + C G+L S R D+DEC +D VC S C NT + C C GY
Sbjct: 240 TAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYY 299
Query: 504 RPDERSC 510
C
Sbjct: 300 HTQRLEC 306
>CR541934-1|CAG46732.1| 443|Homo sapiens EFEMP2 protein.
Length = 443
Score = 67.3 bits (157), Expect = 5e-10
Identities = 65/237 (27%), Positives = 86/237 (36%), Gaps = 25/237 (10%)
Query: 285 DNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK----CIPERWRCDNERDCADGGDELNCKP 340
D D D + C +P +C GE KC + C+P N D G P
Sbjct: 46 DPDSQHCRDVNECLTIPEACK-GEMKCINHYGGYLCLPRSAAVIN--DLHGEGPPPPVPP 102
Query: 341 NSIRN-CSL-----DEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRP 393
N C D+ +C D C C +DC N C +C + P
Sbjct: 103 AQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQC--TCPDGYRKIGP 160
Query: 394 Q-EHLMSNAFRNCVNRKHVCDGMKDCP------RGDDEERCPLKRKCSAEEKCEKLCITT 446
+ + +R C +R G C G + C +C CE+ C +
Sbjct: 161 ECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNS 220
Query: 447 YDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYIL 503
Y G C C G+ L D +SC DIDEC Y +C C N G F C C GY L
Sbjct: 221 Y-GTFLCRCHQGYELHRDGFSCSDIDECSY-SSYLCQYRCVNEPGRFSCHCPQGYQL 275
Score = 58.8 bits (136), Expect = 2e-07
Identities = 47/160 (29%), Positives = 60/160 (37%), Gaps = 14/160 (8%)
Query: 365 CDGVRDCTNGEDEMNCEVSCEEDQ--YTCRPQEHLMSNAFRNCVNRKHVCDGM--KDCPR 420
C V +C + E+ C Y C P+ + N V CP
Sbjct: 52 CRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPP 111
Query: 421 G---DDEERCPLKRKCS-AEEKCE-KLCITTYDGHAACACPMGFLLAEDKYSCRDIDECM 475
G DD++ C +C+ A C G C CP G+ + C DIDEC
Sbjct: 112 GYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPE--CVDIDECR 169
Query: 476 YEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
Y C C N GSFRC C G+ L P+ RSC E
Sbjct: 170 YRY---CQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNE 206
Score = 57.2 bits (132), Expect = 5e-07
Identities = 28/77 (36%), Positives = 36/77 (46%), Gaps = 3/77 (3%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCM 498
C+ C+ G C C GF L + SC D++EC + C Q C N+ G+F C C
Sbjct: 173 CQHRCVNL-PGSFRCQCEPGFQLGPNNRSCVDVNEC--DMGAPCEQRCFNSYGTFLCRCH 229
Query: 499 TGYILRPDERSCKPTGE 515
GY L D SC E
Sbjct: 230 QGYELHRDGFSCSDIDE 246
Score = 44.0 bits (99), Expect = 0.005
Identities = 61/245 (24%), Positives = 92/245 (37%), Gaps = 33/245 (13%)
Query: 277 PKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDEL 336
P ++ D + C D D C C + C++ +P ++C C DG ++
Sbjct: 110 PPGYEPDDQDSC---VDVDECAQALHDCRPSQ-DCHN---LPGSYQCT----CPDGYRKI 158
Query: 337 NCKPNSIRNCSLDEYTCADRRCVLK--TWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ 394
+ I C Y RCV ++ C G + +C E D P
Sbjct: 159 GPECVDIDEC---RYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGA--PC 213
Query: 395 EHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCS-AEEKCEKLCITTYDGHAAC 453
E N++ + R H + D C +CS + C+ C+ G +C
Sbjct: 214 EQRCFNSYGTFLCRCH-----QGYELHRDGFSCSDIDECSYSSYLCQYRCVNE-PGRFSC 267
Query: 454 ACPMGFLLAEDKYSCRDIDECMYEQDPVCS--QTCSNTVGSFRC----GCMTGYILRPDE 507
CP G+ L + C+DIDEC CS QTC N G +RC C+ YI +
Sbjct: 268 HCPQGYQLLATRL-CQDIDECESGAHQ-CSEAQTCVNFHGGYRCVDTNRCVEPYIQVSEN 325
Query: 508 RSCKP 512
R P
Sbjct: 326 RCLCP 330
>BC010456-1|AAH10456.1| 443|Homo sapiens EGF-containing
fibulin-like extracellular matrix protein 2 protein.
Length = 443
Score = 67.3 bits (157), Expect = 5e-10
Identities = 65/237 (27%), Positives = 86/237 (36%), Gaps = 25/237 (10%)
Query: 285 DNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK----CIPERWRCDNERDCADGGDELNCKP 340
D D D + C +P +C GE KC + C+P N D G P
Sbjct: 46 DPDSQHCRDVNECLTIPEACK-GEMKCINHYGGYLCLPRSAAVIN--DLHGEGPPPPVPP 102
Query: 341 NSIRN-CSL-----DEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRP 393
N C D+ +C D C C +DC N C +C + P
Sbjct: 103 AQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQC--TCPDGYRKIGP 160
Query: 394 Q-EHLMSNAFRNCVNRKHVCDGMKDCP------RGDDEERCPLKRKCSAEEKCEKLCITT 446
+ + +R C +R G C G + C +C CE+ C +
Sbjct: 161 ECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNS 220
Query: 447 YDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYIL 503
Y G C C G+ L D +SC DIDEC Y +C C N G F C C GY L
Sbjct: 221 Y-GTFLCRCHQGYELHRDGFSCSDIDECSY-SSYLCQYRCVNEPGRFSCHCPQGYQL 275
Score = 58.8 bits (136), Expect = 2e-07
Identities = 47/160 (29%), Positives = 60/160 (37%), Gaps = 14/160 (8%)
Query: 365 CDGVRDCTNGEDEMNCEVSCEEDQ--YTCRPQEHLMSNAFRNCVNRKHVCDGM--KDCPR 420
C V +C + E+ C Y C P+ + N V CP
Sbjct: 52 CRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPP 111
Query: 421 G---DDEERCPLKRKCS-AEEKCE-KLCITTYDGHAACACPMGFLLAEDKYSCRDIDECM 475
G DD++ C +C+ A C G C CP G+ + C DIDEC
Sbjct: 112 GYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPE--CVDIDECR 169
Query: 476 YEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
Y C C N GSFRC C G+ L P+ RSC E
Sbjct: 170 YRY---CQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNE 206
Score = 57.2 bits (132), Expect = 5e-07
Identities = 28/77 (36%), Positives = 36/77 (46%), Gaps = 3/77 (3%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCM 498
C+ C+ G C C GF L + SC D++EC + C Q C N+ G+F C C
Sbjct: 173 CQHRCVNL-PGSFRCQCEPGFQLGPNNRSCVDVNEC--DMGAPCEQRCFNSYGTFLCRCH 229
Query: 499 TGYILRPDERSCKPTGE 515
GY L D SC E
Sbjct: 230 QGYELHRDGFSCSDIDE 246
Score = 44.0 bits (99), Expect = 0.005
Identities = 61/245 (24%), Positives = 92/245 (37%), Gaps = 33/245 (13%)
Query: 277 PKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDEL 336
P ++ D + C D D C C + C++ +P ++C C DG ++
Sbjct: 110 PPGYEPDDQDSC---VDVDECAQALHDCRPSQ-DCHN---LPGSYQCT----CPDGYRKI 158
Query: 337 NCKPNSIRNCSLDEYTCADRRCVLK--TWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ 394
+ I C Y RCV ++ C G + +C E D P
Sbjct: 159 GPECVDIDEC---RYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGA--PC 213
Query: 395 EHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCS-AEEKCEKLCITTYDGHAAC 453
E N++ + R H + D C +CS + C+ C+ G +C
Sbjct: 214 EQRCFNSYGTFLCRCH-----QGYELHRDGFSCSDIDECSYSSYLCQYRCVNE-PGRFSC 267
Query: 454 ACPMGFLLAEDKYSCRDIDECMYEQDPVCS--QTCSNTVGSFRC----GCMTGYILRPDE 507
CP G+ L + C+DIDEC CS QTC N G +RC C+ YI +
Sbjct: 268 HCPQGYQLLATRL-CQDIDECESGAHQ-CSEAQTCVNFHGGYRCVDTNRCVEPYIQVSEN 325
Query: 508 RSCKP 512
R P
Sbjct: 326 RCLCP 330
>AY358899-1|AAQ89258.1| 443|Homo sapiens EFEMP2 protein.
Length = 443
Score = 67.3 bits (157), Expect = 5e-10
Identities = 65/237 (27%), Positives = 86/237 (36%), Gaps = 25/237 (10%)
Query: 285 DNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK----CIPERWRCDNERDCADGGDELNCKP 340
D D D + C +P +C GE KC + C+P N D G P
Sbjct: 46 DPDSQHCRDVNECLTIPEACK-GEMKCINHYGGYLCLPRSAAVIN--DLHGEGPPPPVPP 102
Query: 341 NSIRN-CSL-----DEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRP 393
N C D+ +C D C C +DC N C +C + P
Sbjct: 103 AQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQC--TCPDGYRKIGP 160
Query: 394 Q-EHLMSNAFRNCVNRKHVCDGMKDCP------RGDDEERCPLKRKCSAEEKCEKLCITT 446
+ + +R C +R G C G + C +C CE+ C +
Sbjct: 161 ECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNS 220
Query: 447 YDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYIL 503
Y G C C G+ L D +SC DIDEC Y +C C N G F C C GY L
Sbjct: 221 Y-GTFLCRCHQGYELHRDGFSCSDIDECSY-SSYLCQYRCVNEPGRFSCHCPQGYQL 275
Score = 58.8 bits (136), Expect = 2e-07
Identities = 47/160 (29%), Positives = 60/160 (37%), Gaps = 14/160 (8%)
Query: 365 CDGVRDCTNGEDEMNCEVSCEEDQ--YTCRPQEHLMSNAFRNCVNRKHVCDGM--KDCPR 420
C V +C + E+ C Y C P+ + N V CP
Sbjct: 52 CRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPP 111
Query: 421 G---DDEERCPLKRKCS-AEEKCE-KLCITTYDGHAACACPMGFLLAEDKYSCRDIDECM 475
G DD++ C +C+ A C G C CP G+ + C DIDEC
Sbjct: 112 GYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPE--CVDIDECR 169
Query: 476 YEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
Y C C N GSFRC C G+ L P+ RSC E
Sbjct: 170 YRY---CQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNE 206
Score = 57.2 bits (132), Expect = 5e-07
Identities = 28/77 (36%), Positives = 36/77 (46%), Gaps = 3/77 (3%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCM 498
C+ C+ G C C GF L + SC D++EC + C Q C N+ G+F C C
Sbjct: 173 CQHRCVNL-PGSFRCQCEPGFQLGPNNRSCVDVNEC--DMGAPCEQRCFNSYGTFLCRCH 229
Query: 499 TGYILRPDERSCKPTGE 515
GY L D SC E
Sbjct: 230 QGYELHRDGFSCSDIDE 246
Score = 44.0 bits (99), Expect = 0.005
Identities = 61/245 (24%), Positives = 92/245 (37%), Gaps = 33/245 (13%)
Query: 277 PKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDEL 336
P ++ D + C D D C C + C++ +P ++C C DG ++
Sbjct: 110 PPGYEPDDQDSC---VDVDECAQALHDCRPSQ-DCHN---LPGSYQCT----CPDGYRKI 158
Query: 337 NCKPNSIRNCSLDEYTCADRRCVLK--TWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ 394
+ I C Y RCV ++ C G + +C E D P
Sbjct: 159 GPECVDIDEC---RYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGA--PC 213
Query: 395 EHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCS-AEEKCEKLCITTYDGHAAC 453
E N++ + R H + D C +CS + C+ C+ G +C
Sbjct: 214 EQRCFNSYGTFLCRCH-----QGYELHRDGFSCSDIDECSYSSYLCQYRCVNE-PGRFSC 267
Query: 454 ACPMGFLLAEDKYSCRDIDECMYEQDPVCS--QTCSNTVGSFRC----GCMTGYILRPDE 507
CP G+ L + C+DIDEC CS QTC N G +RC C+ YI +
Sbjct: 268 HCPQGYQLLATRL-CQDIDECESGAHQ-CSEAQTCVNFHGGYRCVDTNRCVEPYIQVSEN 325
Query: 508 RSCKP 512
R P
Sbjct: 326 RCLCP 330
>AJ132819-1|CAA10791.2| 443|Homo sapiens fibulin-4 protein.
Length = 443
Score = 67.3 bits (157), Expect = 5e-10
Identities = 65/237 (27%), Positives = 86/237 (36%), Gaps = 25/237 (10%)
Query: 285 DNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK----CIPERWRCDNERDCADGGDELNCKP 340
D D D + C +P +C GE KC + C+P N D G P
Sbjct: 46 DPDSQHCRDVNECLTIPEACK-GEMKCINHYGGYLCLPRSAAVIN--DLHGEGPPPPVPP 102
Query: 341 NSIRN-CSL-----DEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRP 393
N C D+ +C D C C +DC N C +C + P
Sbjct: 103 AQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQC--TCPDGYRKIGP 160
Query: 394 Q-EHLMSNAFRNCVNRKHVCDGMKDCP------RGDDEERCPLKRKCSAEEKCEKLCITT 446
+ + +R C +R G C G + C +C CE+ C +
Sbjct: 161 ECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNS 220
Query: 447 YDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYIL 503
Y G C C G+ L D +SC DIDEC Y +C C N G F C C GY L
Sbjct: 221 Y-GTFLCRCHQGYELHRDGFSCSDIDECSY-SSYLCQYRCVNEPGRFSCHCPQGYQL 275
Score = 58.8 bits (136), Expect = 2e-07
Identities = 47/160 (29%), Positives = 60/160 (37%), Gaps = 14/160 (8%)
Query: 365 CDGVRDCTNGEDEMNCEVSCEEDQ--YTCRPQEHLMSNAFRNCVNRKHVCDGM--KDCPR 420
C V +C + E+ C Y C P+ + N V CP
Sbjct: 52 CRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPP 111
Query: 421 G---DDEERCPLKRKCS-AEEKCE-KLCITTYDGHAACACPMGFLLAEDKYSCRDIDECM 475
G DD++ C +C+ A C G C CP G+ + C DIDEC
Sbjct: 112 GYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPE--CVDIDECR 169
Query: 476 YEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
Y C C N GSFRC C G+ L P+ RSC E
Sbjct: 170 YRY---CQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNE 206
Score = 57.2 bits (132), Expect = 5e-07
Identities = 28/77 (36%), Positives = 36/77 (46%), Gaps = 3/77 (3%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCM 498
C+ C+ G C C GF L + SC D++EC + C Q C N+ G+F C C
Sbjct: 173 CQHRCVNL-PGSFRCQCEPGFQLGPNNRSCVDVNEC--DMGAPCEQRCFNSYGTFLCRCH 229
Query: 499 TGYILRPDERSCKPTGE 515
GY L D SC E
Sbjct: 230 QGYELHRDGFSCSDIDE 246
Score = 44.0 bits (99), Expect = 0.005
Identities = 61/245 (24%), Positives = 92/245 (37%), Gaps = 33/245 (13%)
Query: 277 PKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDEL 336
P ++ D + C D D C C + C++ +P ++C C DG ++
Sbjct: 110 PPGYEPDDQDSC---VDVDECAQALHDCRPSQ-DCHN---LPGSYQCT----CPDGYRKI 158
Query: 337 NCKPNSIRNCSLDEYTCADRRCVLK--TWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ 394
+ I C Y RCV ++ C G + +C E D P
Sbjct: 159 GPECVDIDEC---RYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGA--PC 213
Query: 395 EHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCS-AEEKCEKLCITTYDGHAAC 453
E N++ + R H + D C +CS + C+ C+ G +C
Sbjct: 214 EQRCFNSYGTFLCRCH-----QGYELHRDGFSCSDIDECSYSSYLCQYRCVNE-PGRFSC 267
Query: 454 ACPMGFLLAEDKYSCRDIDECMYEQDPVCS--QTCSNTVGSFRC----GCMTGYILRPDE 507
CP G+ L + C+DIDEC CS QTC N G +RC C+ YI +
Sbjct: 268 HCPQGYQLLATRL-CQDIDECESGAHQ-CSEAQTCVNFHGGYRCVDTNRCVEPYIQVSEN 325
Query: 508 RSCKP 512
R P
Sbjct: 326 RCLCP 330
>AF109121-1|AAF65188.1| 443|Homo sapiens EGF-containing
fibulin-like extracellular matrix protein 2 protein.
Length = 443
Score = 67.3 bits (157), Expect = 5e-10
Identities = 65/237 (27%), Positives = 86/237 (36%), Gaps = 25/237 (10%)
Query: 285 DNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK----CIPERWRCDNERDCADGGDELNCKP 340
D D D + C +P +C GE KC + C+P N D G P
Sbjct: 46 DPDSQHCRDVNECLTIPEACK-GEMKCINHYGGYLCLPRSAAVIN--DLHGEGPPPPVPP 102
Query: 341 NSIRN-CSL-----DEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRP 393
N C D+ +C D C C +DC N C +C + P
Sbjct: 103 AQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQC--TCPDGYRKIGP 160
Query: 394 Q-EHLMSNAFRNCVNRKHVCDGMKDCP------RGDDEERCPLKRKCSAEEKCEKLCITT 446
+ + +R C +R G C G + C +C CE+ C +
Sbjct: 161 ECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNS 220
Query: 447 YDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYIL 503
Y G C C G+ L D +SC DIDEC Y +C C N G F C C GY L
Sbjct: 221 Y-GTFLCRCHQGYELHRDGFSCSDIDECSY-SSYLCQYRCVNEPGRFSCHCPQGYQL 275
Score = 58.8 bits (136), Expect = 2e-07
Identities = 47/160 (29%), Positives = 60/160 (37%), Gaps = 14/160 (8%)
Query: 365 CDGVRDCTNGEDEMNCEVSCEEDQ--YTCRPQEHLMSNAFRNCVNRKHVCDGM--KDCPR 420
C V +C + E+ C Y C P+ + N V CP
Sbjct: 52 CRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPP 111
Query: 421 G---DDEERCPLKRKCS-AEEKCE-KLCITTYDGHAACACPMGFLLAEDKYSCRDIDECM 475
G DD++ C +C+ A C G C CP G+ + C DIDEC
Sbjct: 112 GYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPE--CVDIDECR 169
Query: 476 YEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
Y C C N GSFRC C G+ L P+ RSC E
Sbjct: 170 YRY---CQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNE 206
Score = 57.2 bits (132), Expect = 5e-07
Identities = 28/77 (36%), Positives = 36/77 (46%), Gaps = 3/77 (3%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCM 498
C+ C+ G C C GF L + SC D++EC + C Q C N+ G+F C C
Sbjct: 173 CQHRCVNL-PGSFRCQCEPGFQLGPNNRSCVDVNEC--DMGAPCEQRCFNSYGTFLCRCH 229
Query: 499 TGYILRPDERSCKPTGE 515
GY L D SC E
Sbjct: 230 QGYELHRDGFSCSDIDE 246
Score = 44.0 bits (99), Expect = 0.005
Identities = 61/245 (24%), Positives = 92/245 (37%), Gaps = 33/245 (13%)
Query: 277 PKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDEL 336
P ++ D + C D D C C + C++ +P ++C C DG ++
Sbjct: 110 PPGYEPDDQDSC---VDVDECAQALHDCRPSQ-DCHN---LPGSYQCT----CPDGYRKI 158
Query: 337 NCKPNSIRNCSLDEYTCADRRCVLK--TWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ 394
+ I C Y RCV ++ C G + +C E D P
Sbjct: 159 GPECVDIDEC---RYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGA--PC 213
Query: 395 EHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCS-AEEKCEKLCITTYDGHAAC 453
E N++ + R H + D C +CS + C+ C+ G +C
Sbjct: 214 EQRCFNSYGTFLCRCH-----QGYELHRDGFSCSDIDECSYSSYLCQYRCVNE-PGRFSC 267
Query: 454 ACPMGFLLAEDKYSCRDIDECMYEQDPVCS--QTCSNTVGSFRC----GCMTGYILRPDE 507
CP G+ L + C+DIDEC CS QTC N G +RC C+ YI +
Sbjct: 268 HCPQGYQLLATRL-CQDIDECESGAHQ-CSEAQTCVNFHGGYRCVDTNRCVEPYIQVSEN 325
Query: 508 RSCKP 512
R P
Sbjct: 326 RCLCP 330
>AB177800-1|BAD16736.1| 2809|Homo sapiens fibrillin 3 protein.
Length = 2809
Score = 67.3 bits (157), Expect = 5e-10
Identities = 65/235 (27%), Positives = 86/235 (36%), Gaps = 34/235 (14%)
Query: 293 DEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDELNCKPNS---IRNCSLD 349
D D C P C G DG ++C C G EL K + I CSL
Sbjct: 1071 DVDECARDPLLCWGGTCTNTDGS-----YKCQ----CPPG-HELTAKGTACEDIDECSLS 1120
Query: 350 EYTCADRRCV--LKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVN 407
+ C +CV + + C + D C V E CR Q +C+N
Sbjct: 1121 DGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGC-VDINE----CRVQN---GGCDVHCIN 1172
Query: 408 RKHVCDGMKDCPRGDDEERCPLKRKCSAEEKCE---KLC----ITTYDGHAACACPMGFL 460
+G C G P R C+ ++CE ++C T G C C GF+
Sbjct: 1173 T----EGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFM 1228
Query: 461 LAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
D +C D+DEC C NT GSF C C GY++R C E
Sbjct: 1229 ATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDE 1283
Score = 66.5 bits (155), Expect = 8e-10
Identities = 34/92 (36%), Positives = 45/92 (48%), Gaps = 3/92 (3%)
Query: 423 DEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC 482
D + C +C+ C DG +C C GFLLA + C DIDEC + +C
Sbjct: 525 DGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDEC--QTPGIC 582
Query: 483 -SQTCSNTVGSFRCGCMTGYILRPDERSCKPT 513
+ C+NT GSFRC C+ G + D R C T
Sbjct: 583 VNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDT 614
Score = 64.9 bits (151), Expect = 2e-09
Identities = 32/71 (45%), Positives = 40/71 (56%), Gaps = 3/71 (4%)
Query: 432 KCSAEEK-CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTV 490
+CS K C LC T G C+CP G+LL ED +C+D+DEC Q C C NTV
Sbjct: 2408 ECSQVPKPCTFLCKNT-KGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHN-CQFLCVNTV 2465
Query: 491 GSFRCGCMTGY 501
G+F C C G+
Sbjct: 2466 GAFTCRCPPGF 2476
Score = 64.5 bits (150), Expect = 3e-09
Identities = 66/250 (26%), Positives = 95/250 (38%), Gaps = 36/250 (14%)
Query: 293 DEDSCPMVPGS----CNAGEFKCNDGKCIPERWRCD-NERDCADGGDELNCKPNSIRNCS 347
D+ C +PG C G D + + CD N C G E N K + + +C
Sbjct: 1208 DQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCE-NTKGSFVCHCQ 1266
Query: 348 LDEYTCADRRCVLKTWLCDGVRDCTNGEDEMNCEVSCEE--DQYTCRPQEHLMSNAFR-- 403
L R+ C V +C G + SC ++CR + + F
Sbjct: 1267 LGYMV---RKGATG---CSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH 1320
Query: 404 ---NCVNRKHVCDGMKDCPRGDDEERCPLKRK-------CSAEEKCEK---LC----ITT 446
CV+++H C DC RC ++ C ++C + LC
Sbjct: 1321 DLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN 1380
Query: 447 YDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCS-QTCSNTVGSFRCGCMTGYILRP 505
G C C MGF ED +C+D+DEC Q +C+ +C N G FRC C GY L
Sbjct: 1381 APGGYRCECEMGFDPTEDHRACQDVDEC--AQGNLCAFGSCENLPGMFRCICNGGYELDR 1438
Query: 506 DERSCKPTGE 515
+C E
Sbjct: 1439 GGGNCTDINE 1448
Score = 63.3 bits (147), Expect = 8e-09
Identities = 37/104 (35%), Positives = 48/104 (46%), Gaps = 9/104 (8%)
Query: 418 CPRG----DDEERCPLKRKC-SAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDID 472
CPRG +D C +C S + C+ LC+ T G C CP GF + +C D D
Sbjct: 2431 CPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTV-GAFTCRCPPGF--TQHHQACFDND 2487
Query: 473 ECMYEQDPVCSQT-CSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
EC + P + C NT GSFRC C G+ L C+ E
Sbjct: 2488 ECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNE 2531
Score = 60.5 bits (140), Expect = 5e-08
Identities = 32/95 (33%), Positives = 38/95 (40%), Gaps = 6/95 (6%)
Query: 423 DEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVC 482
DE C L C G C CP GF + C+D+DEC + P C
Sbjct: 2568 DENECALSPPTCGSASCRNTL-----GGFRCVCPSGFDFDQALGGCQDVDECAGRRGP-C 2621
Query: 483 SQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESP 517
S +C+NT G F CGC GY G SP
Sbjct: 2622 SYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSP 2656
Score = 59.7 bits (138), Expect = 9e-08
Identities = 29/73 (39%), Positives = 36/73 (49%), Gaps = 2/73 (2%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
CI + G C C G+ +C D+DEC P C+ C NT GSF C C GY+
Sbjct: 2379 CINSL-GSFRCHCQAGYTPDATATTCLDMDECSQVPKP-CTFLCKNTKGSFLCSCPRGYL 2436
Query: 503 LRPDERSCKPTGE 515
L D R+CK E
Sbjct: 2437 LEEDGRTCKDLDE 2449
Score = 58.8 bits (136), Expect = 2e-07
Identities = 32/95 (33%), Positives = 43/95 (45%), Gaps = 9/95 (9%)
Query: 429 LKRKCSAEEKCEK---LC----ITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV 481
L + C ++C + LC T DG C CP G L +C DIDEC D +
Sbjct: 1065 LMKNCMDVDECARDPLLCWGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLS-DGL 1123
Query: 482 CSQ-TCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C C N +G+F+C C G+ PD + C E
Sbjct: 1124 CPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINE 1158
Score = 58.8 bits (136), Expect = 2e-07
Identities = 56/221 (25%), Positives = 78/221 (35%), Gaps = 21/221 (9%)
Query: 307 GEFKCND-GKCIPERWRCDNERDCAD--GGDELNCKPNSIRNCSLDEYTCADR-RCVLKT 362
G C+D +C CD+ C + G C P + D + C D CV +
Sbjct: 1274 GATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVG----DGFECHDLDECVSQE 1329
Query: 363 WLCDGVRDCTN--GEDEMNCEVSCEEDQYTCRPQEHLMSNAFR----NCVNRK--HVCDG 414
C DC N G C D + C ++ N C+N + C+
Sbjct: 1330 HRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCEC 1389
Query: 415 MKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDEC 474
+D C +C+ C G C C G+ L +C DI+EC
Sbjct: 1390 EMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINEC 1449
Query: 475 MYEQDPV-C-SQTCSNTVGSFRCGCMTGYILRPDERSCKPT 513
DPV C + C NT GS+ C C + L P C T
Sbjct: 1450 ---ADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDT 1487
Score = 57.6 bits (133), Expect = 4e-07
Identities = 32/95 (33%), Positives = 44/95 (46%), Gaps = 3/95 (3%)
Query: 423 DEERCPLKRKC-SAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPV 481
D + C +C S C +G C CP GF + D C DIDEC E +
Sbjct: 1923 DGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDH--CIDIDECSEEPNLC 1980
Query: 482 CSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGES 516
TC+N+ GSF+C C G++L + C T +S
Sbjct: 1981 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQS 2015
Score = 56.4 bits (130), Expect = 9e-07
Identities = 27/54 (50%), Positives = 30/54 (55%), Gaps = 2/54 (3%)
Query: 449 GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQ-TCSNTVGSFRCGCMTGY 501
G CAC GF L + +C DIDEC D +C Q TC NT GSF C C GY
Sbjct: 1007 GSFHCACAGGFALDAQERNCTDIDECRISPD-LCGQGTCVNTPGSFECECFPGY 1059
Score = 56.4 bits (130), Expect = 9e-07
Identities = 49/190 (25%), Positives = 77/190 (40%), Gaps = 21/190 (11%)
Query: 339 KPNSIRNCSLDEYTCADRRCV--LKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQEH 396
KP I C CA+ C+ + ++ C+ C G + + ++CE+ +
Sbjct: 1718 KPLDIDECGEIPAICANGICINQIGSFRCE----CPAGFNYNSILLACEDVDECGSRESP 1773
Query: 397 LMSNAFRNCVN-----RKHVCDGMKDCPRGDDEERCPLKRKC-SAEEKCEKLCITTYDGH 450
NA +C+N R G K P G C + +C C +G
Sbjct: 1774 CQQNA--DCINIPGSYRCKCTRGYKLSPGG----ACVGRNECREIPNVCSHGDCMDTEGS 1827
Query: 451 AACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSC 510
C C GF + D+ C DIDEC ++ P + TC N +GS+ C C G+++ C
Sbjct: 1828 YMCLCHRGFQASADQTLCMDIDEC--DRQPCGNGTCKNIIGSYNCLCFPGFVV-THNGDC 1884
Query: 511 KPTGESPTLL 520
E TL+
Sbjct: 1885 VDFDECTTLV 1894
Score = 54.8 bits (126), Expect = 3e-06
Identities = 68/259 (26%), Positives = 98/259 (37%), Gaps = 34/259 (13%)
Query: 275 CVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGD 334
C P G + C D D C PG C G +G +RC A G D
Sbjct: 557 CKPGFLLAPGGHYC---MDIDEC-QTPGICVNGHCTNTEGS-----FRCQCLGGLAVGTD 607
Query: 335 ELNCKPNSIRN-C--SLDEYTCADR--RCVLKTWLCDGVRDCTNGEDEMNCEV-SCEEDQ 388
C +R+ C ++++ +CA V K+ C D GE C + E Q
Sbjct: 608 GRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKNSAEFQ 667
Query: 389 YTCRPQEHLMSNA--FRNCVNRKHVC-DGMKDCPRGDDEERCPLK-------RKCSAEEK 438
C + ++ C VC +G+ + RG C L + C+ ++
Sbjct: 668 ALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDE 727
Query: 439 C---EKLCITTY----DGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVG 491
C LC + G +C+CP GF +D C+D+DEC+ P S C N G
Sbjct: 728 CALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECL--SSPCVSGVCRNLAG 785
Query: 492 SFRCGCMTGYILRPDERSC 510
S+ C C G L P C
Sbjct: 786 SYTCKCGPGSRLDPSGTFC 804
Score = 54.4 bits (125), Expect = 4e-06
Identities = 24/75 (32%), Positives = 34/75 (45%), Gaps = 1/75 (1%)
Query: 427 CPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTC 486
C +C +C+ C G+ C+CP GF C D +EC S +C
Sbjct: 2526 CEDVNECDGPHRCQHGCQNQLGGYR-CSCPQGFTQHSQWAQCVDENECALSPPTCGSASC 2584
Query: 487 SNTVGSFRCGCMTGY 501
NT+G FRC C +G+
Sbjct: 2585 RNTLGGFRCVCPSGF 2599
Score = 53.2 bits (122), Expect = 8e-06
Identities = 24/66 (36%), Positives = 32/66 (48%)
Query: 453 CACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP 512
C C GF + +C D+DEC+ C NT GSF+C C G+ L PD ++C
Sbjct: 472 CRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVD 531
Query: 513 TGESPT 518
E T
Sbjct: 532 HNECAT 537
Score = 53.2 bits (122), Expect = 8e-06
Identities = 23/60 (38%), Positives = 31/60 (51%), Gaps = 1/60 (1%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T+ G C CP G+ L+E C DIDEC TC NT+G++ C C Y+
Sbjct: 1579 CVNTF-GSFQCECPPGYHLSEHTRICEDIDECSTHSSICGPGTCYNTLGNYTCVCPAEYL 1637
Score = 52.8 bits (121), Expect = 1e-05
Identities = 72/280 (25%), Positives = 105/280 (37%), Gaps = 37/280 (13%)
Query: 250 PRSTWNQPVELMRCAEIDFECKNTKCVPKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEF 309
P W P EL C + C G +D + D + C PG C G
Sbjct: 2045 PGEGWGDPCEL--CPQEGSAAFQELCPFGHGAVPGPDDSRE--DVNECAENPGVCTNGVC 2100
Query: 310 KCNDGKCIPERWRCDNERDCADGGDELNCKPNSIRNCSLDEYTCADRRCVLKTWLCDGVR 369
DG +RC+ + +NC CS+ + C C T + G
Sbjct: 2101 VNTDGS-----FRCECPFGYSLDFTGINCVDTD--ECSVG-HPCGQGTC---TNVIGGFE 2149
Query: 370 -DCTNGEDEMNCEVSCEE-DQYTCRPQEHLMSNAFRNCVNRK--HVCDGMKDCPRG---- 421
C +G E ++CE+ D+ + P + AFR C N + ++C CP G
Sbjct: 2150 CACADGF-EPGLMMTCEDIDECSLNP----LLCAFR-CHNTEGSYLCT----CPAGYTLR 2199
Query: 422 DDEERCPLKRKCS-AEEKCEKLCITTYD--GHAACACPMGFL-LAEDKYSCRDIDECMYE 477
+D C +C+ ++ C + + G AC CP G L C D +EC +
Sbjct: 2200 EDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQ 2259
Query: 478 QDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGESP 517
D + C NT GSFRC C G+ P C + P
Sbjct: 2260 PDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGP 2299
Score = 51.2 bits (117), Expect = 3e-05
Identities = 31/114 (27%), Positives = 43/114 (37%), Gaps = 6/114 (5%)
Query: 403 RNCVNRKHVCD-GMKDCPRGDDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLL 461
+N + +C G+ G D C L + A CE L G C C +G+
Sbjct: 661 KNSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENL-----RGSYRCVCNLGYEA 715
Query: 462 AEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
C D+DEC + C N+ GS+ C C G+ D CK E
Sbjct: 716 GASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDE 769
Score = 51.2 bits (117), Expect = 3e-05
Identities = 41/139 (29%), Positives = 53/139 (38%), Gaps = 13/139 (9%)
Query: 385 EEDQYTCRPQEHLMS---NAFRNCVNRKHVCDGMKDCPRG--DDEERCPLKRKCSAEE-K 438
EED TC+ + S N CVN V CP G + C +CSA+
Sbjct: 2438 EEDGRTCKDLDECTSRQHNCQFLCVNT--VGAFTCRCPPGFTQHHQACFDNDECSAQPGP 2495
Query: 439 C--EKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCG 496
C C T G C C GF L + C D++EC + C C N +G +RC
Sbjct: 2496 CGAHGHCHNT-PGSFRCECHQGFTLVSSGHGCEDVNEC--DGPHRCQHGCQNQLGGYRCS 2552
Query: 497 CMTGYILRPDERSCKPTGE 515
C G+ C E
Sbjct: 2553 CPQGFTQHSQWAQCVDENE 2571
Score = 49.2 bits (112), Expect = 1e-04
Identities = 27/76 (35%), Positives = 35/76 (46%), Gaps = 2/76 (2%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T +G C C GF L+ D +C D +EC V + C N GSF C C G++
Sbjct: 505 CVNT-EGSFQCVCNAGFELSPDGKNCVDHNECATSTMCV-NGVCLNEDGSFSCLCKPGFL 562
Query: 503 LRPDERSCKPTGESPT 518
L P C E T
Sbjct: 563 LAPGGHYCMDIDECQT 578
Score = 49.2 bits (112), Expect = 1e-04
Identities = 27/72 (37%), Positives = 34/72 (47%), Gaps = 2/72 (2%)
Query: 449 GHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCS-QTCSNTVGSFRCGCMTGYILRPDE 507
G C C GF++ + C D DEC VC C NT GSF C C G+ L D
Sbjct: 1866 GSYNCLCFPGFVVTHNG-DCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADG 1924
Query: 508 RSCKPTGESPTL 519
++C T E +L
Sbjct: 1925 KNCVDTNECLSL 1936
Score = 48.4 bits (110), Expect = 2e-04
Identities = 71/270 (26%), Positives = 99/270 (36%), Gaps = 38/270 (14%)
Query: 263 CAEIDFECKNTKCV--PKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKC--IP 318
CAE C N +C+ P ++C+ + D +C V C G C G C +P
Sbjct: 1366 CAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVD-ECAQGNL-CAFGSCENLP 1423
Query: 319 ERWRCDNERDCADGGDEL-----NCKPNSIRNCSLDEYTCADRRCVLK--TWLCDGVRDC 371
+RC +GG EL NC I C+ D C + C+ ++LC +D
Sbjct: 1424 GMFRC-----ICNGGYELDRGGGNC--TDINECA-DPVNCINGVCINTPGSYLCSCPQDF 1475
Query: 372 TNGEDEMNCEVSCEEDQYTCRPQEHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKR 431
+ C + C + H ++ +C V C C L R
Sbjct: 1476 ELNPSGVGC---VDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCC-------CSLGR 1525
Query: 432 KCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSC--RDIDECMYEQDPVCSQ-TCSN 488
CE LC CP G ++ + DIDEC E +C C N
Sbjct: 1526 AWG--NPCE-LCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQ-ELPGLCQGGDCVN 1581
Query: 489 TVGSFRCGCMTGYILRPDERSCKPTGESPT 518
T GSF+C C GY L R C+ E T
Sbjct: 1582 TFGSFQCECPPGYHLSEHTRICEDIDECST 1611
Score = 48.0 bits (109), Expect = 3e-04
Identities = 24/64 (37%), Positives = 31/64 (48%), Gaps = 1/64 (1%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T G C C GF L D +C D +EC+ TC N GSFRC C G+
Sbjct: 1903 CLNTA-GSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQ 1961
Query: 503 LRPD 506
++ D
Sbjct: 1962 VQSD 1965
Score = 44.8 bits (101), Expect = 0.003
Identities = 24/69 (34%), Positives = 30/69 (43%), Gaps = 5/69 (7%)
Query: 452 ACACPMGFLLAEDKYSC-----RDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPD 506
A CP G A + +D++EC TC NTVGSF C C G+ L
Sbjct: 963 ASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQ 1022
Query: 507 ERSCKPTGE 515
ER+C E
Sbjct: 1023 ERNCTDIDE 1031
Score = 44.0 bits (99), Expect = 0.005
Identities = 23/72 (31%), Positives = 33/72 (45%), Gaps = 2/72 (2%)
Query: 455 CPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKP-- 512
C GF+ +C+D+DEC +C N VGSF C C G+ L +C+
Sbjct: 232 CRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYR 291
Query: 513 TGESPTLLFSNR 524
G ++LF R
Sbjct: 292 AGACFSVLFGGR 303
Score = 41.5 bits (93), Expect = 0.027
Identities = 27/69 (39%), Positives = 31/69 (44%), Gaps = 5/69 (7%)
Query: 454 ACPMGFLLAEDKYSCRDIDECMYEQDP-VCSQ-TCSNTVGSFRCGCMTGYILRPDERSCK 511
AC GF +C D++EC E P VC C NT GSFRC C G +L R C
Sbjct: 854 ACARGFARMTG-VTCDDVNEC--ESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCV 910
Query: 512 PTGESPTLL 520
P L
Sbjct: 911 DVRLEPCFL 919
Score = 41.1 bits (92), Expect = 0.035
Identities = 54/224 (24%), Positives = 73/224 (32%), Gaps = 24/224 (10%)
Query: 304 CNAGEFKCNDGKCIPERWRCDNERDCA-------DGGDELNCKPNSIRNCSLDEYTCADR 356
CNAG DGK + C C DG CKP + + + C D
Sbjct: 516 CNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFL--LAPGGHYCMDI 573
Query: 357 RCVLKTWLCDGVRDCTNGEDEMNCE----VSCEEDQYTCRPQEHLMSNAFRNCVNRKHVC 412
+C CTN E C+ ++ D C H+ S + K C
Sbjct: 574 DECQTPGICVNGH-CTNTEGSFRCQCLGGLAVGTDGRVC-VDTHVRSTCYGAI--EKGSC 629
Query: 413 DGMKDCPRG-DDEERCPLKRKCSAEEKCEKLCITTYDGHAACACPMGFLLAEDKYSCRDI 471
+ P E C E C+ LC C G + D RDI
Sbjct: 630 --ARPFPGTVTKSECCCANPDHGFGEPCQ-LCPAKNSAEFQALCSSGLGITTDG---RDI 683
Query: 472 DECMYEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
+EC + + + C N GS+RC C GY + C E
Sbjct: 684 NECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDE 727
Score = 39.5 bits (88), Expect = 0.11
Identities = 20/73 (27%), Positives = 32/73 (43%), Gaps = 4/73 (5%)
Query: 443 CITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYI 502
C+ T + C C +G+ + + C D+DEC P C N G++ C C G+
Sbjct: 424 CLPTPSSYR-CECNVGYT-QDVRGECIDVDECT--SSPCHHGDCVNIPGTYHCRCYPGFQ 479
Query: 503 LRPDERSCKPTGE 515
P ++C E
Sbjct: 480 ATPTRQACVDVDE 492
Score = 39.5 bits (88), Expect = 0.11
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C NGGC C+ G C+C G L DG+ CAD
Sbjct: 1159 CRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACAD 1196
Score = 37.9 bits (84), Expect = 0.33
Identities = 15/33 (45%), Positives = 18/33 (54%)
Query: 469 RDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGY 501
RD+DEC C N++GSFRC C GY
Sbjct: 2362 RDVDECRMLAHLCAHGECINSLGSFRCHCQAGY 2394
Score = 36.7 bits (81), Expect = 0.76
Identities = 15/38 (39%), Positives = 20/38 (52%)
Query: 1019 CGKNNGGCSHLCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C + C+ LC G C+CP G L +DG+TC D
Sbjct: 2409 CSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKD 2446
Score = 34.7 bits (76), Expect = 3.1
Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 2/36 (5%)
Query: 1023 NGGCSHL--CLLKPGGRSCACPIGIKLNKDGKTCAD 1056
+GG HL C+ G C C G +L+ DGK C D
Sbjct: 496 SGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVD 531
Score = 33.5 bits (73), Expect = 7.0
Identities = 14/39 (35%), Positives = 20/39 (51%), Gaps = 1/39 (2%)
Query: 1019 CGKNNGGCSH-LCLLKPGGRSCACPIGIKLNKDGKTCAD 1056
C +N G C++ +C+ G C CP G L+ G C D
Sbjct: 2088 CAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVD 2126
Score = 33.1 bits (72), Expect = 9.3
Identities = 11/26 (42%), Positives = 14/26 (53%)
Query: 1322 CGTDNGGCSHLCLRSPLGYTCACPTG 1347
C G CS+ C +P G+ C CP G
Sbjct: 2614 CAGRRGPCSYSCANTPGGFLCGCPQG 2639
>AB030655-1|BAA92880.1| 443|Homo sapiens mutant p53 binding protein
1 (MBP1) protein.
Length = 443
Score = 67.3 bits (157), Expect = 5e-10
Identities = 65/237 (27%), Positives = 86/237 (36%), Gaps = 25/237 (10%)
Query: 285 DNDCGDWTDEDSCPMVPGSCNAGEFKCNDGK----CIPERWRCDNERDCADGGDELNCKP 340
D D D + C +P +C GE KC + C+P N D G P
Sbjct: 46 DPDSQHCRDVNECLTIPEACK-GEMKCINHYGGYLCLPRSAAVIN--DLHGEGPPPPVPP 102
Query: 341 NSIRN-CSL-----DEYTCAD-RRCVLKTWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRP 393
N C D+ +C D C C +DC N C +C + P
Sbjct: 103 AQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQC--TCPDGYRKIGP 160
Query: 394 Q-EHLMSNAFRNCVNRKHVCDGMKDCP------RGDDEERCPLKRKCSAEEKCEKLCITT 446
+ + +R C +R G C G + C +C CE+ C +
Sbjct: 161 ECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNS 220
Query: 447 YDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCMTGYIL 503
Y G C C G+ L D +SC DIDEC Y +C C N G F C C GY L
Sbjct: 221 Y-GTFLCRCHQGYELHRDGFSCSDIDECSY-SSYLCQYRCVNEPGRFSCHCPQGYQL 275
Score = 58.8 bits (136), Expect = 2e-07
Identities = 47/160 (29%), Positives = 60/160 (37%), Gaps = 14/160 (8%)
Query: 365 CDGVRDCTNGEDEMNCEVSCEEDQ--YTCRPQEHLMSNAFRNCVNRKHVCDGM--KDCPR 420
C V +C + E+ C Y C P+ + N V CP
Sbjct: 52 CRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPP 111
Query: 421 G---DDEERCPLKRKCS-AEEKCE-KLCITTYDGHAACACPMGFLLAEDKYSCRDIDECM 475
G DD++ C +C+ A C G C CP G+ + C DIDEC
Sbjct: 112 GYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPE--CVDIDECR 169
Query: 476 YEQDPVCSQTCSNTVGSFRCGCMTGYILRPDERSCKPTGE 515
Y C C N GSFRC C G+ L P+ RSC E
Sbjct: 170 YRY---CQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNE 206
Score = 57.2 bits (132), Expect = 5e-07
Identities = 28/77 (36%), Positives = 36/77 (46%), Gaps = 3/77 (3%)
Query: 439 CEKLCITTYDGHAACACPMGFLLAEDKYSCRDIDECMYEQDPVCSQTCSNTVGSFRCGCM 498
C+ C+ G C C GF L + SC D++EC + C Q C N+ G+F C C
Sbjct: 173 CQHRCVNL-PGSFRCQCEPGFQLGPNNRSCVDVNEC--DMGAPCEQRCFNSYGTFLCRCH 229
Query: 499 TGYILRPDERSCKPTGE 515
GY L D SC E
Sbjct: 230 QGYELHRDGFSCSDIDE 246
Score = 44.0 bits (99), Expect = 0.005
Identities = 61/245 (24%), Positives = 92/245 (37%), Gaps = 33/245 (13%)
Query: 277 PKDFQCDGDNDCGDWTDEDSCPMVPGSCNAGEFKCNDGKCIPERWRCDNERDCADGGDEL 336
P ++ D + C D D C C + C++ +P ++C C DG ++
Sbjct: 110 PPGYEPDDQDSC---VDVDECAQALHDCRPSQ-DCHN---LPGSYQCT----CPDGYRKI 158
Query: 337 NCKPNSIRNCSLDEYTCADRRCVLK--TWLCDGVRDCTNGEDEMNCEVSCEEDQYTCRPQ 394
+ I C Y RCV ++ C G + +C E D P
Sbjct: 159 GPECVDIDEC---RYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGA--PC 213
Query: 395 EHLMSNAFRNCVNRKHVCDGMKDCPRGDDEERCPLKRKCS-AEEKCEKLCITTYDGHAAC 453
E N++ + R H + D C +CS + C+ C+ G +C
Sbjct: 214 EQRCFNSYGTFLCRCH-----QGYELHRDGFSCSDIDECSYSSYLCQYRCVNE-PGRFSC 267
Query: 454 ACPMGFLLAEDKYSCRDIDECMYEQDPVCS--QTCSNTVGSFRC----GCMTGYILRPDE 507
CP G+ L + C+DIDEC CS QTC N G +RC C+ YI +
Sbjct: 268 HCPQGYQLLATRL-CQDIDECESGAHQ-CSEAQTCVNFHGGYRCVDTNRCVEPYIQVSEN 325
Query: 508 RSCKP 512
R P
Sbjct: 326 RCLCP 330
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.319 0.137 0.449
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 298,499,482
Number of Sequences: 224733
Number of extensions: 14164733
Number of successful extensions: 56932
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 571
Number of HSP's successfully gapped in prelim test: 329
Number of HSP's that attempted gapping in prelim test: 33695
Number of HSP's gapped (non-prelim): 10917
length of query: 1776
length of database: 73,234,838
effective HSP length: 100
effective length of query: 1676
effective length of database: 50,761,538
effective search space: 85076337688
effective search space used: 85076337688
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.8 bits)
S2: 72 (33.1 bits)
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