Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001255-TA|BGIBMGA001255-PA|IPR001054|Adenylyl cyclase
class-3/4/guanylyl cyclase
(607 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_UPI0000DB755E Cluster: PREDICTED: similar to Adenylyl c... 614 e-174
UniRef50_UPI00015B5E7D Cluster: PREDICTED: similar to adenylate ... 599 e-169
UniRef50_Q7QEP6 Cluster: ENSANGP00000019838; n=3; Bilateria|Rep:... 410 e-113
UniRef50_O16039 Cluster: Adenylyl cyclase isoform DAC9; n=4; Sop... 393 e-108
UniRef50_UPI0000D55CA0 Cluster: PREDICTED: similar to CG9210-PA,... 389 e-106
UniRef50_O60503 Cluster: Adenylate cyclase type 9; n=29; Euteleo... 350 6e-95
UniRef50_UPI0000E49494 Cluster: PREDICTED: similar to adenylyl c... 343 6e-93
UniRef50_Q19523 Cluster: Putative uncharacterized protein acy-1;... 322 2e-86
UniRef50_A7RN58 Cluster: Predicted protein; n=2; Nematostella ve... 263 1e-68
UniRef50_Q16W55 Cluster: Adenylate cyclase; n=1; Aedes aegypti|R... 209 2e-52
UniRef50_UPI000069E67B Cluster: Adenylate cyclase type 1 (EC 4.6... 207 8e-52
UniRef50_UPI000069E679 Cluster: Adenylate cyclase type 1 (EC 4.6... 207 8e-52
UniRef50_A7RRQ7 Cluster: Predicted protein; n=1; Nematostella ve... 207 8e-52
UniRef50_Q5MAL0 Cluster: Adenylate cyclase; n=2; Eukaryota|Rep: ... 204 7e-51
UniRef50_Q4RR06 Cluster: Chromosome 14 SCAF15003, whole genome s... 203 1e-50
UniRef50_Q08828 Cluster: Adenylate cyclase type 1 (EC 4.6.1.1) (... 202 2e-50
UniRef50_UPI0000D56083 Cluster: PREDICTED: similar to CG10564-PA... 199 2e-49
UniRef50_UPI0000DB7A4D Cluster: PREDICTED: similar to Adenylyl c... 198 3e-49
UniRef50_O95622 Cluster: Adenylate cyclase type 5; n=41; Deutero... 198 5e-49
UniRef50_UPI00005A2FB4 Cluster: PREDICTED: similar to brain aden... 197 8e-49
UniRef50_UPI0000D5745B Cluster: PREDICTED: similar to CG32158-PB... 196 1e-48
UniRef50_Q4STI6 Cluster: Chromosome undetermined SCAF14199, whol... 194 4e-48
UniRef50_UPI000069F10A Cluster: Adenylate cyclase type 6 (EC 4.6... 194 6e-48
UniRef50_Q5MAL1 Cluster: Adenylate cyclase; n=1; Aplysia califor... 194 8e-48
UniRef50_Q9VV68 Cluster: CG32158-PB, isoform B; n=12; Coelomata|... 193 1e-47
UniRef50_O96306 Cluster: Adenylyl cyclase isoform DAC39E; n=7; D... 193 1e-47
UniRef50_Q4RVX9 Cluster: Chromosome 9 SCAF14991, whole genome sh... 192 3e-47
UniRef50_O60266 Cluster: Adenylate cyclase type 3; n=21; Theria|... 191 4e-47
UniRef50_UPI0000DB73AC Cluster: PREDICTED: similar to Adenylyl c... 191 5e-47
UniRef50_P40145 Cluster: Adenylate cyclase type 8 (EC 4.6.1.1) (... 190 7e-47
UniRef50_Q9VW60 Cluster: Adenylate cyclase type 2; n=2; Sophopho... 190 7e-47
UniRef50_Q7QDV4 Cluster: ENSANGP00000010056; n=1; Anopheles gamb... 190 9e-47
UniRef50_Q8NFM4 Cluster: Adenylate cyclase type 4; n=73; Euteleo... 190 1e-46
UniRef50_Q4T405 Cluster: Chromosome 8 SCAF9864, whole genome sho... 189 2e-46
UniRef50_Q9Y1V0 Cluster: Adenylyl cyclase 78C-L; n=4; Sophophora... 188 4e-46
UniRef50_Q1MU16 Cluster: ORF for hypothetical protein; n=2; Apoc... 188 5e-46
UniRef50_P32870 Cluster: Ca(2+)/calmodulin-responsive adenylate ... 188 5e-46
UniRef50_UPI0000E47CE1 Cluster: PREDICTED: similar to Adenylate ... 186 1e-45
UniRef50_Q5TUN5 Cluster: ENSANGP00000027378; n=2; Culicidae|Rep:... 186 2e-45
UniRef50_Q16XH3 Cluster: Adenylate cyclase; n=3; Endopterygota|R... 186 2e-45
UniRef50_UPI00015A564B Cluster: Novel protein similar to vertebr... 185 3e-45
UniRef50_UPI000065E155 Cluster: Adenylate cyclase type 8 (EC 4.6... 184 5e-45
UniRef50_UPI00015B5F6F Cluster: PREDICTED: similar to ENSANGP000... 184 6e-45
UniRef50_Q4T7J2 Cluster: Chromosome undetermined SCAF8089, whole... 181 4e-44
UniRef50_UPI0000D56082 Cluster: PREDICTED: similar to adenylate ... 180 8e-44
UniRef50_UPI00015A6AA9 Cluster: Adenylate cyclase type 8 (EC 4.6... 179 2e-43
UniRef50_UPI000065D458 Cluster: Adenylate cyclase type 3 (EC 4.6... 177 5e-43
UniRef50_Q5MAL2 Cluster: Adenylate cyclase; n=1; Aplysia califor... 177 9e-43
UniRef50_Q0C7B2 Cluster: Adenylate cyclase; n=2; Culicidae|Rep: ... 176 2e-42
UniRef50_A7S0C5 Cluster: Predicted protein; n=1; Nematostella ve... 174 5e-42
UniRef50_UPI000155DD86 Cluster: PREDICTED: similar to adenylate ... 170 8e-41
UniRef50_Q8MZE0 Cluster: AT09365p; n=1; Drosophila melanogaster|... 169 2e-40
UniRef50_Q966F9 Cluster: Adenylyl cyclase protein 4; n=2; Caenor... 160 1e-37
UniRef50_O16880 Cluster: Adenylyl cyclase protein 2; n=2; Caenor... 155 2e-36
UniRef50_A0YQ82 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC... 154 6e-36
UniRef50_UPI0000DB7252 Cluster: PREDICTED: similar to ACXD CG571... 154 7e-36
UniRef50_Q10XK8 Cluster: Adenylate/guanylate cyclase precursor; ... 152 3e-35
UniRef50_A0YU66 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC... 151 4e-35
UniRef50_Q1H0Z8 Cluster: Adenylate/guanylate cyclase; n=1; Methy... 151 7e-35
UniRef50_A0YN57 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC... 151 7e-35
UniRef50_A0YS29 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC... 150 1e-34
UniRef50_Q9EXQ2 Cluster: Adenylate cyclase; n=3; Oscillatoriales... 147 6e-34
UniRef50_A0YPF4 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC... 146 2e-33
UniRef50_Q4SU92 Cluster: Chromosome 3 SCAF13974, whole genome sh... 145 3e-33
UniRef50_A0YSC8 Cluster: Extracellular ligand-binding receptor; ... 144 5e-33
UniRef50_UPI000038D385 Cluster: COG2114: Adenylate cyclase, fami... 143 1e-32
UniRef50_A7BXS6 Cluster: Adenylate/guanylate cyclase; n=1; Beggi... 142 2e-32
UniRef50_A0YIQ8 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC... 138 3e-31
UniRef50_Q8YZ26 Cluster: Adenylate cyclase; n=1; Nostoc sp. PCC ... 136 1e-30
UniRef50_Q15T90 Cluster: Adenylate/guanylate cyclase; n=1; Pseud... 136 2e-30
UniRef50_Q8F690 Cluster: Adenylate cyclase; n=4; Leptospira|Rep:... 133 1e-29
UniRef50_Q8F1T7 Cluster: Adenylate cyclase; n=2; Leptospira inte... 131 6e-29
UniRef50_Q7WWV9 Cluster: Putative regulatory protein; n=1; Ralst... 130 8e-29
UniRef50_UPI00015B5520 Cluster: PREDICTED: similar to adenylate ... 128 4e-28
UniRef50_Q1NSQ3 Cluster: Adenylate cyclase; n=1; delta proteobac... 128 6e-28
UniRef50_A7C2F8 Cluster: Rh-like protein/ammonium transporter; n... 127 7e-28
UniRef50_Q47AI8 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 127 1e-27
UniRef50_Q5UFR4 Cluster: Cya1625; n=1; Mycobacterium smegmatis|R... 126 2e-27
UniRef50_A1ZSW5 Cluster: Adenylate cyclase; n=1; Microscilla mar... 125 3e-27
UniRef50_P0A4Y1 Cluster: Adenylate cyclase; n=15; Mycobacterium|... 124 5e-27
UniRef50_Q28S34 Cluster: Adenylate/guanylate cyclase; n=1; Janna... 123 2e-26
UniRef50_A0LXB4 Cluster: Secreted protein containing adenylate/g... 122 2e-26
UniRef50_Q394B3 Cluster: Adenylate/guanylate cyclase; n=4; Burkh... 121 5e-26
UniRef50_Q0LMK3 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 119 3e-25
UniRef50_Q89SW2 Cluster: Two-component hybrid sensor and regulat... 118 3e-25
UniRef50_A1ZW48 Cluster: Adenylate cyclase; n=1; Microscilla mar... 118 6e-25
UniRef50_A4AWH6 Cluster: Adenylate/guanylate cyclase; n=1; Flavo... 117 8e-25
UniRef50_Q03100 Cluster: Adenylate cyclase, aggregation specific... 117 8e-25
UniRef50_A1ZSW4 Cluster: Atrial natriuretic peptide receptor A; ... 117 1e-24
UniRef50_A5P0P3 Cluster: Response regulator receiver protein; n=... 116 1e-24
UniRef50_Q7YXG2 Cluster: Soluble guanylyl cyclase 1 beta; n=1; L... 116 1e-24
UniRef50_Q8IQK2 Cluster: Guanylate cyclase; n=6; Diptera|Rep: Gu... 116 2e-24
UniRef50_Q9VN32 Cluster: Guanylate cyclase; n=5; Diptera|Rep: Gu... 115 3e-24
UniRef50_O01779 Cluster: Guanylate cyclase; n=1; Caenorhabditis ... 115 3e-24
UniRef50_Q8T8L6 Cluster: Guanylate cyclase; n=5; Caenorhabditis|... 115 4e-24
UniRef50_A3I1K5 Cluster: Adenylate/guanylate cyclase; n=1; Algor... 113 2e-23
UniRef50_P25092 Cluster: Heat-stable enterotoxin receptor precur... 113 2e-23
UniRef50_A1ZFP4 Cluster: Two-component hybrid sensor and regulat... 112 2e-23
UniRef50_Q8F778 Cluster: Adenylate cyclase; n=3; Leptospira inte... 111 4e-23
UniRef50_Q5YLC2 Cluster: Soluble guanylyl cyclase beta; n=1; Chl... 111 4e-23
UniRef50_Q98GN7 Cluster: Cyclase; n=1; Mesorhizobium loti|Rep: C... 111 5e-23
UniRef50_Q8MLX0 Cluster: CG3216-PB, isoform B; n=7; Endopterygot... 111 5e-23
UniRef50_A3HV63 Cluster: Adenylate or guanylate cyclase; n=1; Al... 111 7e-23
UniRef50_A1ZQH6 Cluster: Heat-stable enterotoxin receptor; n=1; ... 111 7e-23
UniRef50_Q16JH8 Cluster: Soluble guanylate cyclase gcy; n=2; Cul... 111 7e-23
UniRef50_Q8INF0 Cluster: Soluble guanylate cyclase 88E; n=12; Co... 111 7e-23
UniRef50_Q6TL19 Cluster: Guanylate cyclase 2G precursor; n=6; Mu... 110 9e-23
UniRef50_Q8IT60 Cluster: Guanylate cyclase; n=3; Coelomata|Rep: ... 110 1e-22
UniRef50_A2DJ96 Cluster: Adenylate and Guanylate cyclase catalyt... 109 2e-22
UniRef50_A1ZVN3 Cluster: Adenylate or guanylate cyclase; n=1; Mi... 109 2e-22
UniRef50_Q6UCJ4 Cluster: Guanylate cyclase PcGC-M2 precursor; n=... 109 2e-22
UniRef50_P51841 Cluster: Retinal guanylyl cyclase 2 precursor; n... 109 3e-22
UniRef50_A1ZXW2 Cluster: Adenylate cyclase; n=1; Microscilla mar... 108 4e-22
UniRef50_A7RZH8 Cluster: Predicted protein; n=1; Nematostella ve... 108 4e-22
UniRef50_Q23310 Cluster: Guanylate cyclase; n=1; Caenorhabditis ... 108 5e-22
UniRef50_A2GA06 Cluster: Adenylate and Guanylate cyclase catalyt... 107 8e-22
UniRef50_UPI00015B6146 Cluster: PREDICTED: similar to ENSANGP000... 107 1e-21
UniRef50_Q9XTY1 Cluster: Guanylate cyclase; n=2; Caenorhabditis|... 107 1e-21
UniRef50_Q7JP51 Cluster: Guanylate cyclase; n=6; Caenorhabditis|... 107 1e-21
UniRef50_Q09435 Cluster: Guanylate cyclase receptor-type gcy-1 p... 107 1e-21
UniRef50_A2DXM9 Cluster: Adenylate and Guanylate cyclase catalyt... 106 1e-21
UniRef50_Q02846 Cluster: Retinal guanylyl cyclase 1 precursor; n... 106 1e-21
UniRef50_P16065 Cluster: Speract receptor precursor; n=7; Euechi... 106 1e-21
UniRef50_A2BFQ0 Cluster: Guanylate cyclase; n=3; Danio rerio|Rep... 106 2e-21
UniRef50_A6PTF8 Cluster: Putative adenylate/guanylate cyclase; n... 106 2e-21
UniRef50_A1ZJP1 Cluster: Adenylate cyclase; n=1; Microscilla mar... 105 3e-21
UniRef50_O96993 Cluster: Guanylate cyclase; n=1; Heterodera glyc... 105 3e-21
UniRef50_A2EQT4 Cluster: Adenylate and Guanylate cyclase catalyt... 105 5e-21
UniRef50_Q6PG12 Cluster: Adcy3 protein; n=13; Euteleostomi|Rep: ... 104 8e-21
UniRef50_Q03101 Cluster: Adenylate cyclase, germination specific... 104 8e-21
UniRef50_UPI00015B48AF Cluster: PREDICTED: similar to ENSANGP000... 103 1e-20
UniRef50_Q92WJ5 Cluster: Putative regulatory protein; n=2; Sinor... 103 1e-20
UniRef50_A7SPS9 Cluster: Predicted protein; n=11; Eumetazoa|Rep:... 103 1e-20
UniRef50_A2DFE4 Cluster: Adenylate and Guanylate cyclase catalyt... 103 1e-20
UniRef50_Q9VEU5 Cluster: Soluble guanylate cyclase 89Db; n=6; Di... 103 1e-20
UniRef50_UPI00015B6145 Cluster: PREDICTED: similar to guanylate ... 103 1e-20
UniRef50_UPI0000F1EB17 Cluster: PREDICTED: similar to ENSANGP000... 103 1e-20
UniRef50_Q9NGZ8 Cluster: Guanylyl cyclase; n=4; Caenorhabditis|R... 103 1e-20
UniRef50_Q10029 Cluster: Guanylate cyclase; n=1; Caenorhabditis ... 103 2e-20
UniRef50_UPI0000ECB130 Cluster: Guanylate cyclase soluble subuni... 102 2e-20
UniRef50_Q17AF9 Cluster: Guanylate cyclase; n=1; Aedes aegypti|R... 102 2e-20
UniRef50_O16715 Cluster: Guanylate cyclase; n=3; Caenorhabditis|... 102 2e-20
UniRef50_Q1NWK5 Cluster: Guanylate cyclase; n=2; delta proteobac... 102 3e-20
UniRef50_Q19768 Cluster: Guanylate cyclase; n=2; Caenorhabditis|... 102 3e-20
UniRef50_A2FSM3 Cluster: Adenylate and Guanylate cyclase catalyt... 102 3e-20
UniRef50_UPI0000E4745B Cluster: PREDICTED: similar to ENSANGP000... 101 4e-20
UniRef50_Q75V80 Cluster: Guanylate cyclase; n=11; Euteleostomi|R... 101 4e-20
UniRef50_Q1EC29 Cluster: IP04501p; n=7; Endopterygota|Rep: IP045... 101 4e-20
UniRef50_A2FLP2 Cluster: Adenylate and Guanylate cyclase catalyt... 101 4e-20
UniRef50_A2DY07 Cluster: Adenylate and Guanylate cyclase catalyt... 101 4e-20
UniRef50_UPI0000F2B0A8 Cluster: PREDICTED: similar to guanylyl c... 101 6e-20
UniRef50_UPI0000E45ED9 Cluster: PREDICTED: similar to ENSANGP000... 101 6e-20
UniRef50_O77149 Cluster: NO-insensitive guanylyl cyclase; n=1; M... 101 6e-20
UniRef50_A2EII5 Cluster: Adenylate and Guanylate cyclase catalyt... 101 6e-20
UniRef50_UPI0000F1D453 Cluster: PREDICTED: similar to receptor t... 101 7e-20
UniRef50_UPI0000E46159 Cluster: PREDICTED: similar to natriureti... 101 7e-20
UniRef50_UPI0000586706 Cluster: PREDICTED: similar to guanylate ... 101 7e-20
UniRef50_Q17BS6 Cluster: Guanylate cyclase; n=2; Culicidae|Rep: ... 101 7e-20
UniRef50_A7RN70 Cluster: Predicted protein; n=1; Nematostella ve... 101 7e-20
UniRef50_A2FKW6 Cluster: Adenylate and Guanylate cyclase catalyt... 101 7e-20
UniRef50_UPI0000E49095 Cluster: PREDICTED: similar to guanylate ... 100 1e-19
UniRef50_A0QDI3 Cluster: Adenylate and Guanylate cyclase catalyt... 100 1e-19
UniRef50_Q9VF17 Cluster: Guanylate cyclase; n=7; Endopterygota|R... 100 1e-19
UniRef50_UPI0000D5787E Cluster: PREDICTED: similar to CG9783-PA;... 100 1e-19
UniRef50_P16066 Cluster: Atrial natriuretic peptide receptor A p... 100 1e-19
UniRef50_A6FX69 Cluster: Adenylate or guanylate cyclase; n=1; Pl... 99 2e-19
UniRef50_A3WBP2 Cluster: Adenylate/guanylate cyclase; n=1; Eryth... 99 2e-19
UniRef50_Q9VK53 Cluster: CG5983-PA, isoform A; n=13; Sophophora|... 99 2e-19
UniRef50_Q7YXG1 Cluster: Soluble guanylyl cyclase 2 beta; n=1; L... 99 2e-19
UniRef50_A7RN69 Cluster: Predicted protein; n=2; Nematostella ve... 99 2e-19
UniRef50_A3HVA1 Cluster: Adenylate/guanylate cyclase; n=1; Algor... 100 2e-19
UniRef50_Q2L6K5 Cluster: Guanylate cyclase; n=3; Caenorhabditis|... 100 2e-19
UniRef50_A2EEV5 Cluster: Adenylate and Guanylate cyclase catalyt... 100 2e-19
UniRef50_Q4SNI3 Cluster: Chromosome 15 SCAF14542, whole genome s... 99 3e-19
UniRef50_A5P476 Cluster: Putative adenylate/guanylate cyclase; n... 99 3e-19
UniRef50_A2FAE9 Cluster: Adenylate and Guanylate cyclase catalyt... 99 4e-19
UniRef50_Q07553 Cluster: Guanylate cyclase 32E precursor; n=3; D... 99 4e-19
UniRef50_Q7Q9W6 Cluster: ENSANGP00000003998; n=1; Anopheles gamb... 98 5e-19
UniRef50_Q174S2 Cluster: Guanylate cyclase; n=7; Coelomata|Rep: ... 98 5e-19
UniRef50_A2F2E6 Cluster: Adenylate and Guanylate cyclase catalyt... 98 5e-19
UniRef50_Q9VA09 Cluster: CG1470-PA; n=6; Diptera|Rep: CG1470-PA ... 98 7e-19
UniRef50_Q17AS9 Cluster: Adenylate cyclase; n=2; Culicidae|Rep: ... 98 7e-19
UniRef50_P92006 Cluster: Soluble guanylate cyclase gcy-34; n=7; ... 98 7e-19
UniRef50_A2FG49 Cluster: Adenylate and Guanylate cyclase catalyt... 97 9e-19
UniRef50_UPI00015B5A8E Cluster: PREDICTED: similar to ENSANGP000... 97 1e-18
UniRef50_UPI0000E4A009 Cluster: PREDICTED: similar to soluble gu... 97 1e-18
UniRef50_Q4SUW5 Cluster: Chromosome undetermined SCAF13838, whol... 97 1e-18
UniRef50_Q9U317 Cluster: Putative uncharacterized protein gcy-25... 97 1e-18
UniRef50_A2DC46 Cluster: Adenylate and Guanylate cyclase catalyt... 97 2e-18
UniRef50_UPI00006CB402 Cluster: Adenylate and Guanylate cyclase ... 96 2e-18
UniRef50_A2E7P5 Cluster: Adenylate and Guanylate cyclase catalyt... 96 2e-18
UniRef50_A0CQM4 Cluster: Chromosome undetermined scaffold_24, wh... 96 2e-18
UniRef50_Q9GYQ4 Cluster: Guanylyl cyclase protein 8; n=3; Caenor... 96 3e-18
UniRef50_Q2L6K7 Cluster: Recepotor type guanyly cyclase; n=1; Ca... 96 3e-18
UniRef50_A2FW09 Cluster: Adenylate and Guanylate cyclase catalyt... 96 3e-18
UniRef50_Q8TA72 Cluster: Guanylate cyclase; n=2; Eumetazoa|Rep: ... 95 4e-18
UniRef50_Q19187 Cluster: Guanylate cyclase; n=3; Bilateria|Rep: ... 95 5e-18
UniRef50_O97053 Cluster: Guanylate cyclase; n=1; Stichopus japon... 95 5e-18
UniRef50_A2DDF2 Cluster: Adenylate and Guanylate cyclase catalyt... 95 5e-18
UniRef50_Q238W6 Cluster: Adenylate and Guanylate cyclase catalyt... 95 6e-18
UniRef50_Q73RD3 Cluster: Adenylate/guanylate cyclase catalytic d... 94 8e-18
UniRef50_A2FWD6 Cluster: Adenylate and Guanylate cyclase catalyt... 94 8e-18
UniRef50_O75343 Cluster: Guanylate cyclase soluble subunit beta-... 94 8e-18
UniRef50_Q2L6K6 Cluster: Guanylate cyclase; n=3; Caenorhabditis|... 94 1e-17
UniRef50_UPI00006CB3C2 Cluster: Adenylate and Guanylate cyclase ... 93 1e-17
UniRef50_UPI0000586B0F Cluster: PREDICTED: similar to receptor t... 93 2e-17
UniRef50_Q9GT37 Cluster: Guanylate cyclase; n=2; Heterodera glyc... 93 2e-17
UniRef50_A7S7B3 Cluster: Predicted protein; n=1; Nematostella ve... 93 2e-17
UniRef50_Q4BYX5 Cluster: Guanylate cyclase:Histidine kinase, HAM... 93 3e-17
UniRef50_Q9XZS0 Cluster: Guanylyl cyclase; n=4; cellular organis... 93 3e-17
UniRef50_Q02153 Cluster: Guanylate cyclase soluble subunit beta-... 93 3e-17
UniRef50_UPI00006CF863 Cluster: Adenylate and Guanylate cyclase ... 92 3e-17
UniRef50_UPI00006CB738 Cluster: Adenylate and Guanylate cyclase ... 92 3e-17
UniRef50_A0EAN1 Cluster: Chromosome undetermined scaffold_86, wh... 92 5e-17
UniRef50_Q86C56 Cluster: Soluble guanylate cyclase gcy-31; n=4; ... 92 5e-17
UniRef50_A7SJA1 Cluster: Predicted protein; n=4; Eumetazoa|Rep: ... 91 8e-17
UniRef50_A0CKZ5 Cluster: Chromosome undetermined scaffold_20, wh... 91 8e-17
UniRef50_Q23496 Cluster: Guanylate cyclase; n=2; Caenorhabditis|... 91 1e-16
UniRef50_A2F3K7 Cluster: Adenylate and Guanylate cyclase catalyt... 91 1e-16
UniRef50_UPI0000E47581 Cluster: PREDICTED: similar to natriureti... 90 1e-16
UniRef50_A2FID0 Cluster: Adenylate and Guanylate cyclase catalyt... 90 2e-16
UniRef50_A2EN44 Cluster: Adenylate and Guanylate cyclase catalyt... 90 2e-16
UniRef50_Q4TAT8 Cluster: Guanylate cyclase; n=2; Tetraodontidae|... 89 2e-16
UniRef50_Q4S9A3 Cluster: Chromosome undetermined SCAF14699, whol... 89 3e-16
UniRef50_UPI000155CC3E Cluster: PREDICTED: similar to adenylate ... 89 4e-16
UniRef50_Q9GT36 Cluster: Guanylate cyclase; n=1; Heterodera glyc... 89 4e-16
UniRef50_A7S7B2 Cluster: Predicted protein; n=1; Nematostella ve... 89 4e-16
UniRef50_A0DVQ1 Cluster: Chromosome undetermined scaffold_66, wh... 89 4e-16
UniRef50_A0BPN4 Cluster: Chromosome undetermined scaffold_12, wh... 89 4e-16
UniRef50_Q96KY6 Cluster: ADCY4 protein; n=20; Euteleostomi|Rep: ... 88 6e-16
UniRef50_Q9N9H5 Cluster: Guanylyl cyclase; n=3; Plasmodium falci... 88 7e-16
UniRef50_Q95NK5 Cluster: Soluble guanylyl cyclase beta1; n=2; St... 88 7e-16
UniRef50_Q22AU0 Cluster: Adenylate and Guanylate cyclase catalyt... 88 7e-16
UniRef50_Q18331 Cluster: Guanylyl cyclase protein 11; n=2; Caeno... 88 7e-16
UniRef50_Q4SW10 Cluster: Guanylate cyclase; n=4; Tetraodontidae|... 87 1e-15
UniRef50_A0C5P9 Cluster: Chromosome undetermined scaffold_150, w... 87 1e-15
UniRef50_Q5SR07 Cluster: Natriuretic peptide receptor A/guanylat... 87 1e-15
UniRef50_P90895 Cluster: Soluble guanylate cyclase gcy-33; n=2; ... 87 1e-15
UniRef50_A7RUA8 Cluster: Predicted protein; n=1; Nematostella ve... 87 2e-15
UniRef50_A0C5Y1 Cluster: Chromosome undetermined scaffold_151, w... 87 2e-15
UniRef50_A5K544 Cluster: Adenylate and Guanylate cyclase catalyt... 86 2e-15
UniRef50_A2EII6 Cluster: Adenylate and Guanylate cyclase catalyt... 86 3e-15
UniRef50_Q6WIQ8 Cluster: Adenylate cyclase type VII; n=2; Xenopu... 85 4e-15
UniRef50_Q8IGU9 Cluster: RE26442p; n=4; Sophophora|Rep: RE26442p... 84 9e-15
UniRef50_O62026 Cluster: Putative uncharacterized protein gcy-29... 84 9e-15
UniRef50_O16544 Cluster: Guanylate cyclase; n=3; Caenorhabditis|... 84 9e-15
UniRef50_A2DLQ6 Cluster: Adenylate and Guanylate cyclase catalyt... 84 9e-15
UniRef50_Q9XVV4 Cluster: Guanylate cyclase; n=2; Caenorhabditis|... 84 1e-14
UniRef50_A0DTD8 Cluster: Chromosome undetermined scaffold_63, wh... 84 1e-14
UniRef50_A0CEN0 Cluster: Chromosome undetermined scaffold_172, w... 84 1e-14
UniRef50_Q9U928 Cluster: Guanylyl cyclase; n=2; Tetrahymena pyri... 83 2e-14
UniRef50_A7RN72 Cluster: Predicted protein; n=1; Nematostella ve... 83 2e-14
UniRef50_A2ES71 Cluster: Adenylate and Guanylate cyclase catalyt... 83 2e-14
UniRef50_A2EN10 Cluster: Adenylate and Guanylate cyclase catalyt... 83 2e-14
UniRef50_Q9GVB8 Cluster: Guanylyl cyclase enzyme; n=3; Plasmodiu... 83 2e-14
UniRef50_Q4Z354 Cluster: Guanylyl cyclase, putative; n=8; Plasmo... 83 2e-14
UniRef50_UPI00005841ED Cluster: PREDICTED: similar to soluble gu... 83 3e-14
UniRef50_Q6BG52 Cluster: Guanylyl cyclase, putative; n=4; Parame... 83 3e-14
UniRef50_A2F3J3 Cluster: Adenylate and Guanylate cyclase catalyt... 83 3e-14
UniRef50_A0D3H6 Cluster: Chromosome undetermined scaffold_36, wh... 82 4e-14
UniRef50_UPI00006975C6 Cluster: Guanylyl CYclase family member (... 81 6e-14
UniRef50_UPI00006D0DB9 Cluster: Sodium/calcium exchanger protein... 81 8e-14
UniRef50_O02298 Cluster: Soluble guanylate cyclase gcy-35; n=2; ... 81 8e-14
UniRef50_A0MJN0 Cluster: Guanylate cyclase beta; n=11; Plasmodiu... 81 1e-13
UniRef50_UPI0000E4627A Cluster: PREDICTED: similar to membrane g... 80 2e-13
UniRef50_UPI00006CFA91 Cluster: Adenylate and Guanylate cyclase ... 80 2e-13
UniRef50_Q4SY29 Cluster: Guanylate cyclase; n=2; Tetraodontidae|... 80 2e-13
UniRef50_UPI0000DB7371 Cluster: PREDICTED: similar to Guanylyl c... 79 3e-13
UniRef50_A0E8U0 Cluster: Cation-transporting ATPase; n=4; Parame... 79 3e-13
UniRef50_Q23TD7 Cluster: Adenylate and Guanylate cyclase catalyt... 79 3e-13
UniRef50_A2FZG6 Cluster: Adenylate and Guanylate cyclase catalyt... 79 3e-13
UniRef50_A2DBX9 Cluster: Adenylate and Guanylate cyclase catalyt... 79 3e-13
UniRef50_A0C7P7 Cluster: Chromosome undetermined scaffold_156, w... 79 4e-13
UniRef50_UPI00006CEB6E Cluster: Adenylate and Guanylate cyclase ... 78 6e-13
UniRef50_A7BYP5 Cluster: Adenylate/guanylate cyclase; n=1; Beggi... 78 6e-13
UniRef50_Q8IRF5 Cluster: CG32305-PA; n=2; Sophophora|Rep: CG3230... 78 6e-13
UniRef50_Q231I7 Cluster: Adenylate and Guanylate cyclase catalyt... 78 6e-13
UniRef50_A2F7J9 Cluster: Adenylate and Guanylate cyclase catalyt... 78 6e-13
UniRef50_A2ECV6 Cluster: Adenylate and Guanylate cyclase catalyt... 78 6e-13
UniRef50_A2E4D6 Cluster: Adenylate and Guanylate cyclase catalyt... 78 6e-13
UniRef50_A2G2Z5 Cluster: Adenylate and Guanylate cyclase catalyt... 78 8e-13
UniRef50_A2FPM7 Cluster: Adenylate and Guanylate cyclase catalyt... 78 8e-13
UniRef50_A2DWV8 Cluster: Adenylate and Guanylate cyclase catalyt... 78 8e-13
UniRef50_A2DKP6 Cluster: Adenylate and Guanylate cyclase catalyt... 78 8e-13
UniRef50_A7AX98 Cluster: Adenylate and guanylate cyclase catalyt... 77 1e-12
UniRef50_A2DJR4 Cluster: Adenylate and Guanylate cyclase catalyt... 77 1e-12
UniRef50_A2G2M4 Cluster: Adenylate and Guanylate cyclase catalyt... 77 2e-12
UniRef50_Q90WX1 Cluster: Guanylyl cyclase 2; n=7; Eumetazoa|Rep:... 76 2e-12
UniRef50_Q4N3Z0 Cluster: Cation-transporting ATPase; n=1; Theile... 76 3e-12
UniRef50_Q23DS0 Cluster: Adenylate and Guanylate cyclase catalyt... 76 3e-12
UniRef50_A0BG69 Cluster: Chromosome undetermined scaffold_105, w... 76 3e-12
UniRef50_Q4UFI5 Cluster: Cation-transporting ATPase; n=1; Theile... 75 6e-12
UniRef50_A5NV94 Cluster: Response regulator receiver protein; n=... 75 7e-12
UniRef50_A3YYJ3 Cluster: Putative uncharacterized protein; n=1; ... 74 1e-11
UniRef50_A2DTD4 Cluster: Adenylate and Guanylate cyclase catalyt... 74 1e-11
UniRef50_Q8I4N4 Cluster: Putative uncharacterized protein daf-11... 74 1e-11
UniRef50_A2FB45 Cluster: Adenylate and Guanylate cyclase catalyt... 73 3e-11
UniRef50_A2D8T2 Cluster: Adenylate and Guanylate cyclase catalyt... 73 3e-11
UniRef50_Q4RYJ0 Cluster: Guanylate cyclase; n=2; Tetraodontidae|... 72 4e-11
UniRef50_Q4RZV3 Cluster: Chromosome 18 SCAF14786, whole genome s... 72 5e-11
UniRef50_A2GB93 Cluster: Adenylate and Guanylate cyclase catalyt... 71 7e-11
UniRef50_A0EHP6 Cluster: Cation-transporting ATPase; n=3; Parame... 71 7e-11
UniRef50_Q24GP9 Cluster: Adenylate and Guanylate cyclase catalyt... 71 1e-10
UniRef50_Q9W037 Cluster: CG32301-PA; n=1; Drosophila melanogaste... 70 2e-10
UniRef50_A0P034 Cluster: Adenylate cyclase; n=1; Stappia aggrega... 69 3e-10
UniRef50_P33402 Cluster: Guanylate cyclase soluble subunit alpha... 66 2e-09
UniRef50_UPI000065CD57 Cluster: Heat-stable enterotoxin receptor... 66 3e-09
UniRef50_Q02108 Cluster: Guanylate cyclase soluble subunit alpha... 66 3e-09
UniRef50_Q4T7S3 Cluster: Guanylate cyclase; n=1; Tetraodon nigro... 65 6e-09
UniRef50_Q0VR65 Cluster: Adenylate cyclase; n=1; Alcanivorax bor... 65 6e-09
UniRef50_Q9ERL9 Cluster: Guanylate cyclase soluble subunit alpha... 65 6e-09
UniRef50_Q07093 Cluster: Head-specific guanylate cyclase; n=8; E... 64 8e-09
UniRef50_UPI000155633D Cluster: PREDICTED: hypothetical protein,... 62 3e-08
UniRef50_Q8F375 Cluster: Adenylate cyclase; n=6; Leptospira|Rep:... 62 3e-08
UniRef50_A7NLF3 Cluster: Adenylate/guanylate cyclase with GAF se... 62 3e-08
UniRef50_Q5BXY8 Cluster: SJCHGC07735 protein; n=1; Schistosoma j... 62 3e-08
UniRef50_UPI00015B5C60 Cluster: PREDICTED: similar to soluble gu... 62 6e-08
UniRef50_Q7ZSZ5 Cluster: Soluble guanylyl cyclase alpha2 subunit... 60 1e-07
UniRef50_A0LFQ6 Cluster: Adenylate/guanylate cyclase; n=1; Syntr... 60 1e-07
UniRef50_Q2BGD8 Cluster: Adenylate cyclase; n=1; Neptuniibacter ... 60 2e-07
UniRef50_Q1PXG2 Cluster: Putative uncharacterized protein; n=1; ... 59 3e-07
UniRef50_Q7A2H3 Cluster: Adenylate cyclase; n=5; Nostocaceae|Rep... 59 4e-07
UniRef50_Q1VN94 Cluster: Two-component hybrid sensor and regulat... 59 4e-07
UniRef50_Q4T0M0 Cluster: Guanylate cyclase; n=1; Tetraodon nigro... 58 5e-07
UniRef50_A0Y7P2 Cluster: Adenylate/guanylate cyclase; n=1; marin... 57 1e-06
UniRef50_A0LB38 Cluster: Adenylate/guanylate cyclase; n=1; Magne... 57 1e-06
UniRef50_Q18628 Cluster: Putative uncharacterized protein acy-3;... 57 2e-06
UniRef50_Q7A2D9 Cluster: Adenylate cyclase; n=6; Cyanobacteria|R... 56 4e-06
UniRef50_Q7YWK7 Cluster: Soluble guanylate cyclase subunit; n=1;... 56 4e-06
UniRef50_Q6E6T5 Cluster: L3i88 isoform b; n=5; Dictyocaulus vivi... 56 4e-06
UniRef50_Q8DGN6 Cluster: Adenylate cyclase; n=1; Synechococcus e... 55 5e-06
UniRef50_Q0EZJ3 Cluster: Adenylate cyclase; n=1; Mariprofundus f... 55 5e-06
UniRef50_Q4RZ92 Cluster: Chromosome 1 SCAF14944, whole genome sh... 54 1e-05
UniRef50_A7BYP4 Cluster: Guanylyl cyclase; n=1; Beggiatoa sp. PS... 54 1e-05
UniRef50_Q17010 Cluster: Soluble guanylate cyclase; n=14; Cellia... 54 1e-05
UniRef50_Q2LS04 Cluster: Adenylate cyclase; n=1; Syntrophus acid... 54 1e-05
UniRef50_A6GG85 Cluster: Putative adenylate cyclase; n=1; Plesio... 52 3e-05
UniRef50_A4BGN9 Cluster: Adenylate cyclase, family 3; n=1; Reine... 52 3e-05
UniRef50_Q98GL0 Cluster: Mlr3277 protein; n=5; Rhizobiales|Rep: ... 52 4e-05
UniRef50_Q5CUX5 Cluster: P-type ATpase fused to two adenyl cycla... 52 4e-05
UniRef50_Q1DD79 Cluster: Adenylate/guanylate cyclase domain prot... 52 6e-05
UniRef50_A0LFQ5 Cluster: Adenylate/guanylate cyclase precursor; ... 52 6e-05
UniRef50_A6PCE2 Cluster: Putative adenylate/guanylate cyclase pr... 51 8e-05
UniRef50_A0L8N6 Cluster: Adenylate/guanylate cyclase; n=1; Magne... 51 8e-05
UniRef50_UPI00005A96A3 Cluster: PREDICTED: similar to adenylate ... 51 1e-04
UniRef50_A6GEM5 Cluster: Adenylate cyclase; n=1; Plesiocystis pa... 51 1e-04
UniRef50_UPI0000E490E0 Cluster: PREDICTED: similar to guanylate ... 50 1e-04
UniRef50_Q5ZVW6 Cluster: Adenylate cyclase 1 protein; n=4; Legio... 50 1e-04
UniRef50_A1G651 Cluster: Adenylate/guanylate cyclase; n=2; Salin... 50 1e-04
UniRef50_A0Y8Z4 Cluster: Adenylate cyclase; n=1; marine gamma pr... 50 1e-04
UniRef50_Q98DR2 Cluster: Adenylate cyclase; n=1; Mesorhizobium l... 50 2e-04
UniRef50_Q8F2W9 Cluster: Adenylate cyclase; n=4; Leptospira|Rep:... 50 2e-04
UniRef50_Q3SKZ7 Cluster: Putative Adenylate/Guanylate Cyclase; n... 50 2e-04
UniRef50_Q3SK56 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 50 2e-04
UniRef50_Q113T7 Cluster: Adenylate/guanylate cyclase; n=1; Trich... 50 2e-04
UniRef50_Q0YLX9 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 50 2e-04
UniRef50_Q8YVS0 Cluster: Adenylate cyclase; n=6; Cyanobacteria|R... 49 3e-04
UniRef50_Q2JH00 Cluster: Adenylate/guanylate cyclase; n=4; Frank... 49 3e-04
UniRef50_Q1MJZ0 Cluster: Putative adenylate/guanylate cyclase; n... 49 3e-04
UniRef50_A1ZWP2 Cluster: Putative uncharacterized protein; n=1; ... 49 3e-04
UniRef50_A0YWU6 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC... 49 3e-04
UniRef50_A6GS32 Cluster: Adenylate/guanylate cyclase; n=1; Limno... 49 4e-04
UniRef50_Q61150 Cluster: Guanylyl cyclase C; n=6; Euteleostomi|R... 48 5e-04
UniRef50_Q73L79 Cluster: Adenylate cyclase, putative; n=1; Trepo... 48 5e-04
UniRef50_Q2SJM3 Cluster: Adenylate cyclase, family 3; n=1; Hahel... 48 5e-04
UniRef50_A4BFI0 Cluster: Adenylate cyclase, family 3; n=1; Reine... 48 5e-04
UniRef50_Q8EXU0 Cluster: Adenylate cyclase; n=2; Leptospira inte... 48 7e-04
UniRef50_Q5FPD7 Cluster: Adenylate cyclase; n=1; Gluconobacter o... 48 7e-04
UniRef50_Q3JC76 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 48 7e-04
UniRef50_A6QBE3 Cluster: Adenylate cyclase/guanylate cyclase; n=... 48 7e-04
UniRef50_Q2LSB8 Cluster: Adenylate and guanylate cyclase catalyt... 48 0.001
UniRef50_Q08MU2 Cluster: Putative uncharacterized protein; n=2; ... 48 0.001
UniRef50_A4XM29 Cluster: Putative adenylate/guanylate cyclase; n... 48 0.001
UniRef50_Q6DNF3 Cluster: Soluble guanylate cyclase gcy-37; n=2; ... 48 0.001
UniRef50_Q8F7F2 Cluster: Adenylate cyclase; n=2; Leptospira inte... 47 0.001
UniRef50_Q8F6W6 Cluster: Adenylate cyclase; n=2; Leptospira inte... 47 0.001
UniRef50_Q1M6K1 Cluster: Putative transmembrane adenylate cyclas... 47 0.001
UniRef50_Q1GD86 Cluster: Adenylate/guanylate cyclase; n=4; Rhodo... 47 0.001
UniRef50_Q04UM6 Cluster: Adenylate cyclase related protein; n=4;... 47 0.001
UniRef50_Q2IUL6 Cluster: Adenylate/guanylate cyclase precursor; ... 47 0.002
UniRef50_Q2BPD5 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 47 0.002
UniRef50_A6G1S4 Cluster: Putative adenylate cyclase; n=1; Plesio... 47 0.002
UniRef50_A4GJB3 Cluster: Adenylate/guanylate cyclase; n=1; uncul... 47 0.002
UniRef50_A3EW56 Cluster: Adenylate cyclase; n=1; Leptospirillum ... 47 0.002
UniRef50_O83498 Cluster: Adenylate cyclase; n=1; Treponema palli... 46 0.002
UniRef50_Q0LGQ8 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 46 0.002
UniRef50_A5UWN3 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 46 0.002
UniRef50_Q9JK77 Cluster: Adenylyl cyclase 3; n=7; Euteleostomi|R... 46 0.003
UniRef50_Q8F210 Cluster: Adenylate cyclase; n=2; Leptospira inte... 46 0.003
UniRef50_A3YU70 Cluster: Guanylyl cyclase; n=1; Synechococcus sp... 46 0.003
UniRef50_Q7QVY5 Cluster: GLP_160_8766_6838; n=1; Giardia lamblia... 46 0.003
UniRef50_Q5N0S8 Cluster: Guanylyl cyclase; n=2; Synechococcus el... 46 0.004
UniRef50_Q39P44 Cluster: Adenylate/guanylate cyclase; n=9; Burkh... 46 0.004
UniRef50_Q1YP13 Cluster: Probable adenylate cyclase; n=1; gamma ... 46 0.004
UniRef50_Q1N6Q8 Cluster: Probable adenylate cyclase; n=1; Oceano... 46 0.004
UniRef50_Q0VSG5 Cluster: Adenylate cyclase family proteine ident... 46 0.004
UniRef50_Q0LCB6 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 46 0.004
UniRef50_Q09E49 Cluster: Adenylate cyclase 2; n=2; Stigmatella a... 46 0.004
UniRef50_Q0LHB3 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 45 0.005
UniRef50_A4C4S0 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 45 0.005
UniRef50_Q5ZVF0 Cluster: Adenylate cyclase PLUS two component hy... 45 0.007
UniRef50_Q2LQ30 Cluster: HD domain protein; n=1; Syntrophus acid... 45 0.007
UniRef50_Q1N5D6 Cluster: Adenylate cyclase; n=1; Oceanobacter sp... 45 0.007
UniRef50_Q0BS82 Cluster: Two-component sensor and regulator; n=1... 45 0.007
UniRef50_Q8EXW3 Cluster: Adenylate cyclase; n=2; Leptospira inte... 44 0.009
UniRef50_Q89CC0 Cluster: Bll7877 protein; n=1; Bradyrhizobium ja... 44 0.009
UniRef50_A1T6C4 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 44 0.009
UniRef50_Q0F3A7 Cluster: Adenylate/guanylate cyclase; n=1; Marip... 44 0.012
UniRef50_Q89K68 Cluster: Bll5043 protein; n=2; Bradyrhizobiaceae... 44 0.016
UniRef50_Q8RNM6 Cluster: Adenylate cyclase; n=5; Legionella pneu... 44 0.016
UniRef50_Q1QA64 Cluster: Adenylate/guanylate cyclase; n=1; Psych... 44 0.016
UniRef50_Q1IJR6 Cluster: Adenylate/guanylate cyclase; n=1; Acido... 44 0.016
UniRef50_Q73P67 Cluster: Adenylate/guanylate cyclase catalytic d... 43 0.021
UniRef50_Q1N335 Cluster: Adenylate cyclase, family 3; n=1; Ocean... 43 0.021
UniRef50_Q1GZE1 Cluster: Adenylate/guanylate cyclase; n=1; Methy... 43 0.021
UniRef50_A0P1E4 Cluster: Putative Adenylate/Guanylate cyclase; n... 43 0.021
UniRef50_A0LDY9 Cluster: Adenylate/guanylate cyclase; n=1; Magne... 43 0.021
UniRef50_P40137 Cluster: Adenylate cyclase 1; n=2; Stigmatella a... 43 0.021
UniRef50_Q4TB76 Cluster: Chromosome undetermined SCAF7184, whole... 43 0.027
UniRef50_Q9HZ23 Cluster: CyaB; n=13; Gammaproteobacteria|Rep: Cy... 43 0.027
UniRef50_Q09BE7 Cluster: Adenylate cyclase 1; n=1; Stigmatella a... 43 0.027
UniRef50_A7C3X9 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 43 0.027
UniRef50_A0PW43 Cluster: Conserved hypothetical transmembrane pr... 43 0.027
UniRef50_Q7UPH0 Cluster: Adenylate cyclase 1; n=1; Pirellula sp.... 42 0.036
UniRef50_Q5N3R5 Cluster: Guanylyl cyclase; n=2; Synechococcus el... 42 0.036
UniRef50_Q3DYQ5 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 42 0.036
UniRef50_Q21LJ4 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 42 0.036
UniRef50_Q8F152 Cluster: Adenylate cyclase; n=4; Leptospira|Rep:... 42 0.048
UniRef50_A0LM28 Cluster: Adenylate/guanylate cyclase; n=1; Syntr... 42 0.048
UniRef50_Q1IS04 Cluster: Adenylate/guanylate cyclase; n=1; Acido... 42 0.063
UniRef50_A3PVY7 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 42 0.063
UniRef50_A6NJF2 Cluster: Uncharacterized protein NPR2; n=19; Eut... 42 0.063
UniRef50_Q4SW38 Cluster: Chromosome undetermined SCAF13692, whol... 41 0.083
UniRef50_Q5DTS7 Cluster: MKIAA4004 protein; n=2; Murinae|Rep: MK... 41 0.083
UniRef50_Q89SR2 Cluster: Bll2338 protein; n=4; Bradyrhizobiaceae... 41 0.083
UniRef50_Q3E203 Cluster: Extracellular solute-binding protein, f... 41 0.083
UniRef50_Q1YML1 Cluster: Putative adenylate/guanylate cyclase wi... 41 0.083
UniRef50_Q0LGT9 Cluster: Response regulator receiver; n=1; Herpe... 41 0.083
UniRef50_Q07M97 Cluster: Adenylate/guanylate cyclase; n=7; Brady... 41 0.083
UniRef50_A5V6C5 Cluster: Putative adenylate/guanylate cyclase; n... 41 0.083
UniRef50_Q4S4C7 Cluster: Chromosome 2 SCAF14738, whole genome sh... 41 0.11
UniRef50_Q7V427 Cluster: Putative adenylate cyclase precursor; n... 41 0.11
UniRef50_Q3E5U5 Cluster: PAS:Adenylyl cyclase class-3/4/guanylyl... 41 0.11
UniRef50_A7BXW8 Cluster: Adenylate cyclase; n=3; Beggiatoa|Rep: ... 41 0.11
UniRef50_A4Z3F2 Cluster: Putative Adenylate cyclase; n=1; Bradyr... 41 0.11
UniRef50_P40138 Cluster: Adenylate cyclase 2; n=3; Cystobacterin... 41 0.11
UniRef50_Q89CY1 Cluster: Bll7664 protein; n=1; Bradyrhizobium ja... 40 0.15
UniRef50_Q31IK8 Cluster: YeeE/YedE family protein precursor; n=1... 40 0.19
UniRef50_A0LAQ0 Cluster: Adenylate/guanylate cyclase; n=1; Magne... 40 0.19
UniRef50_A0H4A6 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 40 0.19
UniRef50_P19485 Cluster: Adenylate cyclase 1; n=2; Sinorhizobium... 40 0.19
UniRef50_Q8YMH0 Cluster: Adenylate cyclase carring two-component... 40 0.25
UniRef50_Q5YQ69 Cluster: Putative uncharacterized protein; n=1; ... 40 0.25
UniRef50_Q2K476 Cluster: Adenylate cyclase protein; n=4; Rhizobi... 40 0.25
UniRef50_Q7WX64 Cluster: Putative sensor kinase; n=1; Ralstonia ... 40 0.25
UniRef50_Q1DDY9 Cluster: Adenylate/guanylate cyclase domain prot... 40 0.25
UniRef50_A6F3D9 Cluster: Predicted membrane protein; n=1; Marino... 40 0.25
UniRef50_A3WDP1 Cluster: Adenylate/Guanylate Cyclase; n=1; Eryth... 40 0.25
UniRef50_Q9UDB0 Cluster: Type VI adenylyl cyclase; n=12; Euteleo... 39 0.34
UniRef50_Q98LH2 Cluster: Adenylate cyclase; n=1; Mesorhizobium l... 39 0.44
UniRef50_Q98EW6 Cluster: Adenylate cyclase; Cya3; n=1; Mesorhizo... 39 0.44
UniRef50_Q89KX9 Cluster: Bll4769 protein; n=1; Bradyrhizobium ja... 39 0.44
UniRef50_Q7UN49 Cluster: Adenylate cyclase 1; n=1; Pirellula sp.... 39 0.44
UniRef50_Q73QN2 Cluster: Adenylate/guanylate cyclase catalytic d... 39 0.44
UniRef50_Q20XY3 Cluster: Adenylate/guanylate cyclase; n=1; Rhodo... 39 0.44
UniRef50_Q164Z4 Cluster: Conserved domain protein; n=1; Roseobac... 39 0.44
UniRef50_Q04R04 Cluster: Adenylate cyclase domain protein; n=2; ... 39 0.44
UniRef50_A7BVP0 Cluster: Adenylate/Guanylate cyclase; n=1; Beggi... 39 0.44
UniRef50_A3HV31 Cluster: Two-component response regulator; n=1; ... 39 0.44
UniRef50_A1I794 Cluster: Putative adenylate/guanylate cyclase; n... 39 0.44
UniRef50_Q4UE13 Cluster: Topoisomerase-related nucleotidyltransf... 39 0.44
UniRef50_Q22LJ1 Cluster: Putative uncharacterized protein; n=1; ... 39 0.44
UniRef50_Q0URQ4 Cluster: Predicted protein; n=1; Phaeosphaeria n... 39 0.44
UniRef50_Q7M8J2 Cluster: ADENYLATE CYCLASE; n=1; Wolinella succi... 38 0.59
UniRef50_Q7A2G7 Cluster: Adenylate cyclase; n=4; Nostocaceae|Rep... 38 0.59
UniRef50_Q6MJX6 Cluster: Adenylate cyclase; n=1; Bdellovibrio ba... 38 0.59
UniRef50_Q6FCE8 Cluster: Putative adenylate or guanylate cyclase... 38 0.59
UniRef50_Q3E0R2 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 38 0.59
UniRef50_A1WY91 Cluster: Putative adenylate/guanylate cyclase pr... 38 0.59
UniRef50_A1G5M2 Cluster: Adenylate/guanylate cyclase; n=2; Salin... 38 0.59
UniRef50_P43524 Cluster: Adenylate cyclase; n=2; Nostocaceae|Rep... 38 0.59
UniRef50_UPI0000F1FEB6 Cluster: PREDICTED: similar to solble gua... 38 0.78
UniRef50_Q89II7 Cluster: Bll5647 protein; n=5; Bradyrhizobiaceae... 38 0.78
UniRef50_Q6W199 Cluster: Putative uncharacterized protein; n=1; ... 38 0.78
UniRef50_Q1VPS0 Cluster: Adenylate cyclase-related protein; n=1;... 38 0.78
UniRef50_Q0LDH3 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 38 0.78
UniRef50_A0YII8 Cluster: Adenylate cyclase; n=2; Bacteria|Rep: A... 38 0.78
UniRef50_A2FMK6 Cluster: Putative uncharacterized protein; n=1; ... 38 0.78
UniRef50_UPI0000E47CE0 Cluster: PREDICTED: hypothetical protein;... 38 1.0
UniRef50_Q89SY6 Cluster: Blr2264 protein; n=9; Rhizobiales|Rep: ... 38 1.0
UniRef50_Q3DXI8 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 38 1.0
UniRef50_Q1FK87 Cluster: CDP-alcohol phosphatidyltransferase; n=... 38 1.0
UniRef50_Q10W13 Cluster: Adenylate/guanylate cyclase; n=2; Oscil... 38 1.0
UniRef50_A4ARZ8 Cluster: Adenylate cyclase-related protein; n=1;... 38 1.0
UniRef50_Q29CQ0 Cluster: GA15182-PA; n=1; Drosophila pseudoobscu... 38 1.0
UniRef50_Q2K6R9 Cluster: Adenylate cyclase protein; n=4; Rhizobi... 37 1.4
UniRef50_Q1IM50 Cluster: Adenylate/guanylate cyclase precursor; ... 37 1.4
UniRef50_A7CWV1 Cluster: Putative adenylate/guanylate cyclase; n... 37 1.4
UniRef50_A7BT71 Cluster: Beta subunit of photoactivated adenylyl... 37 1.4
UniRef50_A6UG63 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 37 1.4
>UniRef50_UPI0000DB755E Cluster: PREDICTED: similar to Adenylyl
cyclase 35C CG9210-PA, isoform A; n=1; Apis
mellifera|Rep: PREDICTED: similar to Adenylyl cyclase
35C CG9210-PA, isoform A - Apis mellifera
Length = 729
Score = 614 bits (1516), Expect = e-174
Identities = 330/613 (53%), Positives = 409/613 (66%), Gaps = 50/613 (8%)
Query: 3 QIFALNHIANSQNDMLQHRVSGYYTSSQSSLNDLHSKSR-----LPPPLNDQQVQSLQKL 57
Q+F +N +A Q D+L HRVSGYYTSS S+LN H S PP + D KL
Sbjct: 150 QLFLMNGMA--QGDLLAHRVSGYYTSS-STLNSAHEPSSSVPYPFPPAVTDTFGACFHKL 206
Query: 58 RKQSDLQLIRCVQDNARSGINYFVQPPINRFTLCFESDEMERHYRDKAHRSDDC-EDLPP 116
RKQSDLQLIRCVQDN S +YFV+PP++ TL F++ EME+ YR+ AH+ ++C PP
Sbjct: 207 RKQSDLQLIRCVQDNVSSQRSYFVKPPLSSLTLFFKNKEMEKEYRENAHKVNECISGNPP 266
Query: 117 TLTTSRFNTALDILVSALIFLAVSASAFVTCSDWWRIVGWFAFFAVIELVAIALCFYRHY 176
TL TSRFNT DIL+SALI+ AV+ S F+ C + +F I+++A+ LC R
Sbjct: 267 TLATSRFNTYFDILISALIYTAVTISLFLLCDPTLYYMIFFVCATTIQIIAVLLCV-RQL 325
Query: 177 LKWQTHHDPRSVAETFHDSLKIFRKLSDWYPWHLSGGLMISLPILIVLINFSCENTTLPI 236
L P + T + +IF+ S WYPWH+ G +++ LPI + +N++C N
Sbjct: 326 LY------PNMIHSTL--TQQIFKFFSQWYPWHICGAILVGLPITSIFLNYTCSN--FHN 375
Query: 237 LRGEQSFYVYLLCISIVHFCNFTQMNWLAKNTLVTLYAGVFLFVTFLGCHEVNTQYLDGD 296
L + +Y YL+ IS+VHFCNFTQ+N KN LVT + GV LF+ F+ H
Sbjct: 376 LNNFEYYYGYLIFISLVHFCNFTQLNCWMKNFLVT-FMGV-LFLYFIMNH---------- 423
Query: 297 IKLYPQFLAQNLTDYFYPNDNTSDRSENNNTLNYEG---MHHKXXXXXXXXXXXXXXXXX 353
Y Q +NL + F N TLNY H +
Sbjct: 424 -LSYDQ---ENLGNLFI-----------NKTLNYSQEIRYHERLYNSEIFLDMILLLLLV 468
Query: 354 XXXNREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSEN 413
NREFEISYRLSF+ N VA RDK RVQ+M+NQADWLLHNIIP++VADQLK TAKYS+N
Sbjct: 469 WFLNREFEISYRLSFHGNAVAARDKTRVQSMKNQADWLLHNIIPKYVADQLKTTAKYSQN 528
Query: 414 HKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGST 473
HK V IIFASI+NFNE+YDESYL GKEYLR+LNELI DFDELLE+P+F +VEKIKTIGST
Sbjct: 529 HKAVGIIFASIVNFNELYDESYLGGKEYLRVLNELIGDFDELLEKPEFSNVEKIKTIGST 588
Query: 474 FMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVT 533
FMAASGLNP +R + Y HL+QL+DFA+ + KV+++FN DL F ILRIG+N+GDVT
Sbjct: 589 FMAASGLNPQVRQQNEHEYKHLFQLIDFAMTLHKVINDFNRDLLGFKLILRIGFNYGDVT 648
Query: 534 AGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGK 593
AGVIG TKLYYDIWGDAVNIASRMDSTGV RIQV + + VLS RYEFEPRG VYVKGK
Sbjct: 649 AGVIGATKLYYDIWGDAVNIASRMDSTGVAGRIQVAKNVLDVLSERYEFEPRGQVYVKGK 708
Query: 594 DDMNVYLLVGKKD 606
D+M+V+LL+GKKD
Sbjct: 709 DNMDVFLLIGKKD 721
>UniRef50_UPI00015B5E7D Cluster: PREDICTED: similar to adenylate
cyclase type ix; n=1; Nasonia vitripennis|Rep: PREDICTED:
similar to adenylate cyclase type ix - Nasonia
vitripennis
Length = 1314
Score = 599 bits (1478), Expect = e-169
Identities = 316/610 (51%), Positives = 401/610 (65%), Gaps = 33/610 (5%)
Query: 3 QIFALNHIANSQNDMLQHRVSGYYTSSQSSLNDLHSKSR------LPPPLNDQQVQSLQK 56
Q+F +N +A Q D+L RVSGYYTSS S+LN H S PP + D K
Sbjct: 730 QLFLMNGMA--QGDLLGPRVSGYYTSS-STLNSTHEPSSSVPPYPFPPAVTDTFGACFHK 786
Query: 57 LRKQSDLQLIRCVQDNARSGINYFVQPPINRFTLCFESDEMERHYRDKAHR-SDDCEDLP 115
LRKQSDLQLIRCVQDN S +YFV+PP++ TL F++ EME YR+ AH+ S+ P
Sbjct: 787 LRKQSDLQLIRCVQDNVSSQSSYFVKPPLSSVTLFFKNKEMENEYRENAHKASEGIGGNP 846
Query: 116 PTLTTSRFNTALDILVSALIFLAVSASAFVTCSDWWRIVGWFAFFAVIELVAIALCFYRH 175
PTL TSRFNT DIL+SAL++ A++ + F+ C + +F +I++ A+ LC R
Sbjct: 847 PTLATSRFNTYFDILISALVYTAITIALFLLCKPTVHYLVFFGLATLIQIFAVTLCI-RQ 905
Query: 176 YLKWQTHHDPRSVAETFHDSLKIFRKLSDWYPWHLSGGLMISLPILIVLINFSCENTTLP 235
+ ++ TF + +IF+ S WYPWH+ G ++ LPI+ +L+NFSC N+
Sbjct: 906 F----------AMHATF--AHRIFKFFSKWYPWHVCGAFLVGLPIVSILMNFSC-NSLRS 952
Query: 236 ILRGEQSFYVYLLCISIVHFCNFTQMNWLAKNTLVTLYAGVFLFVTFLGCHEVNTQYLDG 295
L + +Y YL+ + +VHFCNFTQ+N KN LVTL G+ LF+ + H + L
Sbjct: 953 SLSHFEYYYSYLVIVGLVHFCNFTQLNCWMKNLLVTL-TGI-LFICLVMSHYSEKKNLMC 1010
Query: 296 DIKLYPQFLAQNLTDYFYPNDNTSDRSENNNTLNYEGMHHKXXXXXXXXXXXXXXXXXXX 355
+ +F D F ND T+ RS N +
Sbjct: 1011 KVLNRNRFFDTGNNDSF--NDQTASRSGKARKYN-----ERLYNSEIFLDLALLLLLVWF 1063
Query: 356 XNREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHK 415
NREFEISYRLSF+ N VA RDK RVQ+M+NQADWLLHNIIP++VADQLK TAKYS+NHK
Sbjct: 1064 LNREFEISYRLSFHGNAVAARDKSRVQSMKNQADWLLHNIIPKYVADQLKTTAKYSQNHK 1123
Query: 416 DVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFM 475
V IIFA+I+NFNE+YDESYL GKEYLR+LNELI DFDELLE+ + +VEKIKTIGSTFM
Sbjct: 1124 AVGIIFATIVNFNELYDESYLGGKEYLRVLNELIGDFDELLEKQDYSNVEKIKTIGSTFM 1183
Query: 476 AASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAG 535
AASGLNP +R S + H+YQL+DFA+ M KV+ +FN DL F ILR+G+NFGDVTAG
Sbjct: 1184 AASGLNPQVRQQSEHEHTHIYQLLDFAMAMHKVIYDFNQDLLGFKLILRVGFNFGDVTAG 1243
Query: 536 VIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDD 595
VIG++KLYYDIWGDAVNIASRMDSTGV IQ C+ V++ RY +EPRG VYVKGKD+
Sbjct: 1244 VIGSSKLYYDIWGDAVNIASRMDSTGVAGEIQFASNCLDVIAERYNYEPRGQVYVKGKDN 1303
Query: 596 MNVYLLVGKK 605
MNV+LL GKK
Sbjct: 1304 MNVFLLKGKK 1313
Score = 86.6 bits (205), Expect = 2e-15
Identities = 61/210 (29%), Positives = 105/210 (50%), Gaps = 16/210 (7%)
Query: 373 VANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHK--DVAIIFASIINFNEM 430
VA+ + + R + D L IP + D +++ + H DV+I+FA I+ F +M
Sbjct: 317 VADWLMEESEREREREDSLKKGSIPSNNTD-IRSLFRPFNMHSMDDVSILFADIVGFTKM 375
Query: 431 YDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRG 490
S +E + ILN+L FD+L E EKI T+G + SG P+ R
Sbjct: 376 --SSNKTAEELVGILNDLFERFDDLCE---LHGCEKISTLGDCYYCVSGC-PEPRP---- 425
Query: 491 TYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDA 550
DH ++ L M + + F+ + E +R+G + G V G++GT + +D+W +
Sbjct: 426 --DHAKCCVEMGLAMIEAIKQFDIERRE-GVNMRVGVHTGTVLCGIVGTKRFKFDVWSND 482
Query: 551 VNIASRMDSTGVPQRIQVGEACVPVLSARY 580
V +A++++STG P R+ + E + L +Y
Sbjct: 483 VTLANKLESTGKPGRVHLSEKTLSFLEEQY 512
>UniRef50_Q7QEP6 Cluster: ENSANGP00000019838; n=3; Bilateria|Rep:
ENSANGP00000019838 - Anopheles gambiae str. PEST
Length = 1536
Score = 410 bits (1009), Expect = e-113
Identities = 193/250 (77%), Positives = 220/250 (88%), Gaps = 5/250 (2%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHKD 416
NREFEI YRLSF+ + VAN+DK RVQNM+NQAD LLHNIIP+HVA+QLKNTAKYSENH +
Sbjct: 1277 NREFEIGYRLSFHGSAVANQDKIRVQNMKNQADMLLHNIIPKHVAEQLKNTAKYSENHHN 1336
Query: 417 VAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMA 476
+ IIFASI+NFNEMYDESYL GKEYLR+LNELI DFDELL RP+F+ VEKIKTIGSTFMA
Sbjct: 1337 IGIIFASIVNFNEMYDESYLGGKEYLRVLNELIGDFDELLARPEFRCVEKIKTIGSTFMA 1396
Query: 477 ASGLNPDLRHASRG-TYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAG 535
ASGL+P +SRG TY+HLY L+DFAL MQ+VV++FN DL EF+ I+R+GYNFGDVTAG
Sbjct: 1397 ASGLDP----SSRGETYEHLYTLLDFALAMQQVVESFNRDLLEFNLIMRVGYNFGDVTAG 1452
Query: 536 VIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDD 595
VIGT+KLYYDIWGDAVN+ASRMDSTGV R+QVG C+PVL RY+FEPRG VYVKGKD
Sbjct: 1453 VIGTSKLYYDIWGDAVNVASRMDSTGVAGRVQVGADCIPVLGERYDFEPRGKVYVKGKDH 1512
Query: 596 MNVYLLVGKK 605
M VYLLVGKK
Sbjct: 1513 MEVYLLVGKK 1522
Score = 179 bits (436), Expect = 2e-43
Identities = 115/289 (39%), Positives = 167/289 (57%), Gaps = 34/289 (11%)
Query: 20 HRVSGYYTSSQSSLNDL------------HSKSR----LPPPLNDQQVQSLQKLRKQSDL 63
HRVSGY+TSSQSSL+ SR L P D LQ+LRKQSDL
Sbjct: 944 HRVSGYFTSSQSSLSGAIVTGGAGAAAAAAPGSRCCMGLKEPHPDPLAACLQQLRKQSDL 1003
Query: 64 QLIRCVQDNARSGINYFVQPPINRFTLCFESDEMERHYRDKAHR-SDDCEDL-----PPT 117
QLIRCV+DNARS +Y V+PP+ +L F+S ME+ +R KAHR + DL PPT
Sbjct: 1004 QLIRCVRDNARSQRSYLVKPPLLPISLRFKSRPMEQEFRSKAHRFGSEGGDLLEGGSPPT 1063
Query: 118 LTTSRFNTALDILVSALIFLAVSASAFVTCS----DWWRI-VGWFAFFAVIELVAIALCF 172
L T ++NT +D+LVS +++LA S S F+ + +++ V F FF+ ++L A+ +C
Sbjct: 1064 LATPKYNTYIDMLVSFVVYLATSTSLFLLSPSVYLESYKVWVCIFVFFSTVQLFALFICT 1123
Query: 173 YR--HYLKWQTHHDPRSVA-ETFHDSLKIFRKLSDWYPWHLSGGLMISLPILIVLINFSC 229
+ + T R VA + +D L + S WYPWH+ GG+++SLP++ +L NF+
Sbjct: 1124 KQVCRRTRKPTVRRSRPVATRSCYDCL--LQLASAWYPWHICGGILMSLPVISILSNFAM 1181
Query: 230 ENTTLPILRGEQSFYVYLLCISIVHFCNFTQMNWLAKNTLVTLYAGVFL 278
+ T R + Y +L+ I IVHFCNFTQ+NW +N + + + F+
Sbjct: 1182 MDVTK--FRVFEFHYGFLMYICIVHFCNFTQLNWWMRNAMACITSAAFV 1228
Score = 79.4 bits (187), Expect = 3e-13
Identities = 56/191 (29%), Positives = 93/191 (48%), Gaps = 18/191 (9%)
Query: 415 KDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTF 474
++V+I+FA I+ F M S ++ + ILN+L FD+L EKI T+G +
Sbjct: 350 ENVSILFADIVGFTRM--SSTKTAEQLVEILNDLFERFDDLC---LVNGCEKISTLGDCY 404
Query: 475 MAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTA 534
SG P+ R DH ++ L M + + F+ E +R+G + G V
Sbjct: 405 YCVSGC-PEPRP------DHAICCVEMGLGMIESIRVFDAQRNE-GIKMRVGVHTGTVLC 456
Query: 535 GVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKD 594
G++GT ++ +D+W + V +A+RM+S+G P ++ V E L Y E V D
Sbjct: 457 GIVGTKRVKFDVWSNDVTLANRMESSGKPDQVHVSEETCGFLGDSYIIEEGEEV-----D 511
Query: 595 DMNVYLLVGKK 605
Y ++GK+
Sbjct: 512 GHRTYFVLGKR 522
>UniRef50_O16039 Cluster: Adenylyl cyclase isoform DAC9; n=4;
Sophophora|Rep: Adenylyl cyclase isoform DAC9 -
Drosophila melanogaster (Fruit fly)
Length = 1708
Score = 393 bits (968), Expect = e-108
Identities = 186/251 (74%), Positives = 216/251 (86%), Gaps = 5/251 (1%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHKD 416
NREFEI YRL+FY N VAN+DK RVQNM+NQAD LLHNIIP+HVA+ LKNTAKYSENH +
Sbjct: 1322 NREFEIGYRLTFYGNAVANQDKVRVQNMKNQADMLLHNIIPKHVAEHLKNTAKYSENHHN 1381
Query: 417 VAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMA 476
+AIIFASI+NFNEMYDESYL GKE+LR+LNELI DFDELL RP+F+ VEKIKTIGSTFMA
Sbjct: 1382 IAIIFASIVNFNEMYDESYLGGKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMA 1441
Query: 477 ASGLNPDLRHASRGTYD-HLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAG 535
ASGL+P + RGT D H++ LM+F++ MQ+VVD FN DL EF+ ILRIG N GDVTAG
Sbjct: 1442 ASGLDP----SHRGTGDEHIHTLMEFSIAMQEVVDAFNKDLLEFNLILRIGMNIGDVTAG 1497
Query: 536 VIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDD 595
VIGT+KLYYDIWGDAVN+ASRMDSTG+P RIQVG+ C+P L+ RYEFEPRGSVYVKGKD
Sbjct: 1498 VIGTSKLYYDIWGDAVNVASRMDSTGLPNRIQVGKDCLPFLTNRYEFEPRGSVYVKGKDH 1557
Query: 596 MNVYLLVGKKD 606
M V+L ++D
Sbjct: 1558 MEVFLYTTRRD 1568
Score = 175 bits (427), Expect = 2e-42
Identities = 123/323 (38%), Positives = 179/323 (55%), Gaps = 55/323 (17%)
Query: 3 QIFALNHIANSQNDMLQHRVSGYYTSSQSSLNDLHSKSRL--------PPPL-------- 46
QI+ALN A SQ HRVSGY+TSS SS+++L L PPPL
Sbjct: 953 QIYALNQTAISQ-----HRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPPLLMPACSSQ 1007
Query: 47 -NDQQVQSLQKLRKQSDLQLIRCVQDNARSGINYFVQPPINRFTLCFESDEMERHYRDKA 105
D LQ+LRKQSDLQLIRCV+DNARS +Y V+PP+ +F+L F+S ++ER +R KA
Sbjct: 1008 MADPLAACLQQLRKQSDLQLIRCVRDNARSQRSYLVKPPLRKFSLYFKSRQLERDFRSKA 1067
Query: 106 HR--SDDCEDLPPTLTTSRFNTALDILVSALIFLAVSASAFV----TCSDWWRI-VGWFA 158
HR +++ + PPTL T R+NT +DI V ++L +S S F+ T S +R+ V F+
Sbjct: 1068 HRFGAENETEGPPTLATPRYNTYIDIFVGIAVYLCISVSLFLMTQNTVSPSFRLWVTLFS 1127
Query: 159 FFAVIELVAIALCFYRHYLKWQTHHDP----RSVAETFHD-------------------S 195
F I++ A+ L F R + Q+ + RS + T D +
Sbjct: 1128 CFTGIQVFALFL-FTRQMCRRQSGSNVSNRFRSKSTTSEDLERDERGAAPGGRPHFESCA 1186
Query: 196 LKIFRKLSDWYPWHLSGGLMISLPILIVLINFSCENTTLPILRGEQSFYVYLLCISIVHF 255
+IF +S WYPWH+ +++++P+L+++ NF L L + Y +L+ + IVHF
Sbjct: 1187 DRIFEAISSWYPWHICLAVLMAMPVLLIIANFLL--LDLEQLEAFEYHYGFLIFVCIVHF 1244
Query: 256 CNFTQMNWLAKNTLVTLYAGVFL 278
CNFTQ+N +N L L A F+
Sbjct: 1245 CNFTQLNCWVRNVLAFLAALCFI 1267
Score = 78.2 bits (184), Expect = 6e-13
Identities = 54/199 (27%), Positives = 99/199 (49%), Gaps = 16/199 (8%)
Query: 393 HNIIPRHVADQLKNTAKYSENH--KDVAIIFASIINFNEMYDESYLKGKEYLRILNELIA 450
H + PR ++ +K+ + H ++V+I+FA I+ F M S ++ + ILN+L
Sbjct: 329 HYMRPR-ASNDVKSLFRPFHMHSMENVSILFADIVGFTRM--SSTKTAEQLVEILNDLFE 385
Query: 451 DFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVD 510
FD+L EKI T+G + SG P+ R DH ++ L M +
Sbjct: 386 RFDDLCS---LSGCEKISTLGDCYYCVSGC-PEPRA------DHAICCVEMGLGMIDAMR 435
Query: 511 NFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGE 570
F+ E +R+G + G V G++GT ++ +D+W + V++A++M+S+G P+++ + +
Sbjct: 436 CFDAQRHE-GVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQ 494
Query: 571 ACVPVLSARYEFEPRGSVY 589
L Y E V+
Sbjct: 495 ETSSFLGDAYYLEEGEEVF 513
>UniRef50_UPI0000D55CA0 Cluster: PREDICTED: similar to CG9210-PA,
isoform A; n=2; Endopterygota|Rep: PREDICTED: similar to
CG9210-PA, isoform A - Tribolium castaneum
Length = 1370
Score = 389 bits (957), Expect = e-106
Identities = 184/249 (73%), Positives = 208/249 (83%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHKD 416
NREFEI YRLSF++N V+NRDK VQN++ QAD+L++NI+P HVA+QLK AKYSEN KD
Sbjct: 1115 NREFEIGYRLSFHANYVSNRDKINVQNLKTQADYLIYNIVPEHVAEQLKKNAKYSENFKD 1174
Query: 417 VAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMA 476
V IIFASI+NFNEMYDESYL GKEYLR+LNELIADFDELL+RP+F VEKIKTIGSTFMA
Sbjct: 1175 VGIIFASIVNFNEMYDESYLGGKEYLRVLNELIADFDELLDRPEFASVEKIKTIGSTFMA 1234
Query: 477 ASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGV 536
ASGLN R + +HLY LMDFALEMQ V+ +FN DL EF+ ILRIGYNFG+VTA V
Sbjct: 1235 ASGLNSTTRRNQKDPNEHLYALMDFALEMQNVITDFNRDLLEFNLILRIGYNFGEVTAAV 1294
Query: 537 IGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDM 596
IG TKLYYDIWGDAVNIASRMDSTGV IQ+GE C+ VL RY F PRGSVYVKGKD+M
Sbjct: 1295 IGNTKLYYDIWGDAVNIASRMDSTGVNGCIQIGENCLQVLETRYVFRPRGSVYVKGKDNM 1354
Query: 597 NVYLLVGKK 605
+VYLL KK
Sbjct: 1355 SVYLLERKK 1363
Score = 169 bits (411), Expect = 2e-40
Identities = 98/260 (37%), Positives = 143/260 (55%), Gaps = 18/260 (6%)
Query: 19 QHRVSGYYTSSQSSLNDLHSKSRLPPPLNDQQVQSLQKLRKQSDLQLIRCVQDNARSGIN 78
+HRVSGYYTSSQS++ R+P D+ +Q LRKQSD QLI+CVQ+N++S +
Sbjct: 835 EHRVSGYYTSSQSTVTSPQYNVRMPGVFKDKFGTCIQNLRKQSDRQLIKCVQENSKSRGS 894
Query: 79 YFVQPPINRFTLCFESDEMERHYRDKAHRSDDCEDLPPTLTTSRFNTALDILVSALIFLA 138
YF++PP+ R TL F+ +ME+ YR H + D TL S+FNT D+ VS+L+F
Sbjct: 895 YFIKPPLRRLTLFFKDKQMEQDYRTNVHSLFEKADSILTLADSKFNTYFDVCVSSLVFAI 954
Query: 139 VSASAFVTCSDWWRIVGWFAFFAVIELVAIALCFYRHYLKWQTHHDPRSVAETFHDSLKI 198
VS S W + G + V+ V +A+ W R V E S +
Sbjct: 955 VSISL-------WLLYGHTTLWLVMSGVFVAI----QACGWAL--CSRKVVEC---SDRC 998
Query: 199 FRKLSDWYPWHLSGGLMISLPILIVLINFSCENTTLPILRGEQSFYVYLLCISIVHFCNF 258
R +S +Y W++ G +++SLP++ VLINF + T Y YLL + ++HFCNF
Sbjct: 999 LRCVSRFYRWNMFGAVLVSLPLVTVLINFCTKVFTTS--ETSNYLYTYLLFVGVIHFCNF 1056
Query: 259 TQMNWLAKNTLVTLYAGVFL 278
TQ+N KN L + +F+
Sbjct: 1057 TQLNCWMKNCLAVAFTLIFI 1076
Score = 90.6 bits (215), Expect = 1e-16
Identities = 54/169 (31%), Positives = 87/169 (51%), Gaps = 13/169 (7%)
Query: 415 KDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTF 474
++V+I+FA I+ F +M + +E + ILN L FD L + F + EKI T+G +
Sbjct: 338 ENVSILFADIVGFTKMASKK--SAEELVEILNNLFQRFDHLCK---FHNCEKISTLGDCY 392
Query: 475 MAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTA 534
SG P+ RH DH ++ L M + + F+ + E +R+G + G V
Sbjct: 393 YCVSGC-PEPRH------DHAKCCVEMGLSMIQAIKQFDQEKNE-GVNMRVGVHTGTVLC 444
Query: 535 GVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFE 583
G++GT + +D+W + V +A+RM+STG P + V E L Y E
Sbjct: 445 GIVGTRRFKFDVWSNDVTLANRMESTGKPGMVHVSEKTCEFLQDMYLLE 493
>UniRef50_O60503 Cluster: Adenylate cyclase type 9; n=29;
Euteleostomi|Rep: Adenylate cyclase type 9 - Homo sapiens
(Human)
Length = 1353
Score = 350 bits (861), Expect = 6e-95
Identities = 217/603 (35%), Positives = 332/603 (55%), Gaps = 48/603 (7%)
Query: 13 SQNDMLQHRVSGYYTSSQSSLND-LHSKSRLPPPLNDQQVQ---SLQKLRKQSDLQLIRC 68
+QN +L T+SQ+SL + L K R DQ + +R+++D +
Sbjct: 672 TQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDV 731
Query: 69 VQDNARSGINYFVQPPINRFTLCFESDEMERHYRDKAHRSDDCEDLP-PTLTTSRFNTAL 127
+++++ +YF +PPIN+F+L F E+ER YR +++ + ++ P T + F++ L
Sbjct: 732 IKEDSLMK-DYFFKPPINQFSLNFLDQELERSYRT-SYQEEVIKNSPVKTFASPTFSSLL 789
Query: 128 DILVSALIFLAVSASAFV-----TCSDWWRIVGWFAFFAVIELVAIALCFYRHYLKWQTH 182
D+ +S +FL +S + F+ T + F+ ++E++++A+ +
Sbjct: 790 DVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIRMVFF----- 844
Query: 183 HDPRSVAETFHDSLKIFRKLSDWYPWHLSGGLMISLPILIVLINFSCE---NTTLPILRG 239
+ + + ++ ++ W P H G +++SLP L V + + E N P+ G
Sbjct: 845 -----LEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHVTSEYETNIHFPVFTG 899
Query: 240 EQSFYVYLLCISIVHFCNFTQMN-WLAKNTLVTLYAGVFLFVTFLGCHEVNTQYLDGDIK 298
+ I++VH+CNF Q++ W+ + + AG L + C D +
Sbjct: 900 SAAL------IAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCP-------DSSVL 946
Query: 299 LYPQFLAQNLTDYFYPNDNTSDRSENNNTLNYEGMHHKXXXXXXXXXXXXXXXXXXXXNR 358
P QN + P +++ R + + G NR
Sbjct: 947 TSPLDAVQNFSSERNPCNSSVPR-DLRRPASLIGQE-------VVLVFFLLLLLVWFLNR 998
Query: 359 EFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHKDVA 418
EFE+SYRL ++ +V A+ + ++Q+MR+QADWLL NIIP HVA+QLK + YS+NH
Sbjct: 999 EFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDSGG 1058
Query: 419 IIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAAS 478
+IFASI+NF+E Y+E+Y GKE R+LNELI DFDELL +P + +EKIKTIG+T+MAAS
Sbjct: 1059 VIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAAS 1118
Query: 479 GLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIG 538
GLN +HL L +FA EM +VVD+FN+++ F+F LR+G+N G +TAGVIG
Sbjct: 1119 GLNTAQAQDGSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIG 1178
Query: 539 TTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSVYVKGKDDMN 597
TTKL YDIWGD VNIASRMD+TGV RIQV E VLS Y+F+ RG+V VKGK M
Sbjct: 1179 TTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMK 1238
Query: 598 VYL 600
YL
Sbjct: 1239 TYL 1241
Score = 85.8 bits (203), Expect = 3e-15
Identities = 61/215 (28%), Positives = 98/215 (45%), Gaps = 27/215 (12%)
Query: 383 NMRNQADWLLHNIIPRHVADQLKNTAKYSENHK--------------DVAIIFASIINFN 428
++ Q D N + RH KN K S K +V+I+FA I+ F
Sbjct: 345 DLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFT 404
Query: 429 EMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHAS 488
+M + + +LN+L FD L E + EKI T+G + +G P+ R
Sbjct: 405 KM--SANKSAHALVGLLNDLFGRFDRLCEETK---CEKISTLGDCYYCVAGC-PEPRA-- 456
Query: 489 RGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWG 548
DH Y ++ L M K ++ F + E +R+G + G V G++G + +D+W
Sbjct: 457 ----DHAYCCIEMGLGMIKAIEQFCQEKKEM-VNMRVGVHTGTVLCGILGMRRFKFDVWS 511
Query: 549 DAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFE 583
+ VN+A+ M+ GV ++ + EA L RYE E
Sbjct: 512 NDVNLANLMEQLGVAGKVHISEATAKYLDDRYEME 546
>UniRef50_UPI0000E49494 Cluster: PREDICTED: similar to adenylyl
cyclase type IX; n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to adenylyl cyclase type IX -
Strongylocentrotus purpuratus
Length = 1073
Score = 343 bits (844), Expect = 6e-93
Identities = 210/556 (37%), Positives = 305/556 (54%), Gaps = 60/556 (10%)
Query: 77 INYFVQPPINRFTLCFESDEMERHYRDK-------AHRSDDCED--------LPPTLTTS 121
++YF +PPI++ +L F + E+E Y + R D D T++T+
Sbjct: 543 MDYFEKPPISQLSLRFNNSEVEDKYHSQFTPDYMQPDRQQDANDDKRNERRHSSETISTT 602
Query: 122 RFNTALDILVSALIFLAVSASAFVTCSDWWRIVGWFAFFAVIEL--VAIALCFYRH-YLK 178
R+NT LD+ ++ F+ V S F+ + W F VI + V I L R + +
Sbjct: 603 RYNTLLDVCIAFATFILVGISCFLVLDI---SIPWAVLFPVISILQVIILLAMIREAFCR 659
Query: 179 WQTHHDPRSVAETFHDSLKIFRKLSDWYPWHLSGGLMISLPILIVLINFSCENTTLPILR 238
+A FH+ WY H+ G L++ P++ V N++C +
Sbjct: 660 NLGIILAEYIAALFHN----------WYRRHILGALLLCCPVIAVFTNYTCNDDGC--FG 707
Query: 239 GEQSFYVYLLCISIVHFCNFTQMNWLAKNTLVTLYAGVFLFVTFLGCHE----VNTQYLD 294
+ F+ +L+ +S++HFCNF Q+N K L+ L +G L V C V+T++ D
Sbjct: 708 ENRLFFCFLIVVSLLHFCNFVQLNMWMK-LLLALVSGTILMVLLFICRSCPVMVDTEFFD 766
Query: 295 GDIKLYPQFLAQNLTDYFYPNDNTSDRSENNNTLNYEGMHHKXXXXXXXXXXXXXXXXXX 354
G P L SD E N+ HH
Sbjct: 767 GTAPT-PYDLVDATPTMM------SDLCEMNS-------HHYVNPEEVILVILLLLILIF 812
Query: 355 XXNREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENH 414
NRE+EI +RL++YSN A D +++++++ +A+ LLH+I+P+ V +QL+ T+K+S+NH
Sbjct: 813 VLNREYEIGFRLNYYSNYQALVDHEKMKSLQEEAEKLLHHIVPQFVTEQLRTTSKFSQNH 872
Query: 415 KDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTF 474
+VA+IF SI+NFN+ Y+E+Y GKE +R+L+ELI+DFD LL P+++ VEKIKTIGST+
Sbjct: 873 DNVAVIFCSIVNFNDFYEEAYEGGKECIRVLHELISDFDNLLNDPKYKEVEKIKTIGSTY 932
Query: 475 MAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFE-----FDFILRIGYNF 529
MAA GL P + + T L LMDF+ EM + FN D+ F+FILRIGYN
Sbjct: 933 MAACGLRPSEKPNNVQT---LITLMDFSDEMMMQLQKFNDDVLSMTIGAFNFILRIGYNH 989
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVY 589
G +T+GVIGTTKL YDIWGD VN+ASRMDSTG+P +QV E + VL YEFE RG V
Sbjct: 990 GKLTSGVIGTTKLLYDIWGDTVNVASRMDSTGMPGHVQVTEHSMTVLEPYYEFEKRGEVK 1049
Query: 590 VKGKDDMNVYLLVGKK 605
V+GK DM YLLV K+
Sbjct: 1050 VRGKGDMTTYLLVKKR 1065
Score = 77.8 bits (183), Expect = 8e-13
Identities = 55/196 (28%), Positives = 92/196 (46%), Gaps = 15/196 (7%)
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYL-RILNELIADFDELLERPQFQHVEKIK 468
Y ++V+I++A I F +M S K E L +LN L FD L R + EKI
Sbjct: 205 YMNRMENVSILYADIAGFTKM---SANKSAEVLVGLLNNLFGRFDLLCRR---HNCEKIC 258
Query: 469 TIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYN 528
T+G + SG P R DH ++ L M + + +F H+ E +R+G +
Sbjct: 259 TLGDCYYCVSGC-PVKRE------DHAQCCVEMGLSMIEAIKDFCHETGE-KVNMRVGIH 310
Query: 529 FGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSV 588
G V G++G + +D+W + V IA++M+++G P ++ V + L RY + +
Sbjct: 311 TGTVLCGIVGNRRFKFDVWSNDVTIANKMEASGQPGKVHVSAESIKFLKERYVLDEGNAD 370
Query: 589 YVKGKDDMNVYLLVGK 604
M Y + G+
Sbjct: 371 KHALLIGMKTYFIAGR 386
>UniRef50_Q19523 Cluster: Putative uncharacterized protein acy-1; n=2;
Caenorhabditis|Rep: Putative uncharacterized protein
acy-1 - Caenorhabditis elegans
Length = 1253
Score = 322 bits (790), Expect = 2e-86
Identities = 202/520 (38%), Positives = 291/520 (55%), Gaps = 37/520 (7%)
Query: 97 MERHYRDKAHRSDDCEDLP-PTLTTSRFNTA-LDILVSALIFLAVSASAFVTCSDW-WRI 153
+ERH +D + + + + T+ R++ +DI+V+ LIF+ A A ++ + +
Sbjct: 744 VERH-KDLMEQGGEKDGITGSTVNKYRYSGVFIDIIVATLIFVISGAVAIMSVRPFPLSL 802
Query: 154 VGWFAFFAVIELVAIALCFYRHYLKWQTHHDPRSVAETFHDSLKIFRKLSDWYPWHLSGG 213
+ +F F A I ++ I L + K F+ + W P HL G
Sbjct: 803 IAYFPFAAAILILTIVL-----------------IGLPLLARKKSFQCANQWMPRHLIGL 845
Query: 214 LMISLPI-LIVLINFSCENTTLP-ILRGEQSFYVYLLCISIVHFCNFTQMNWLAKNTLVT 271
L+I LPI + + I C++ ++ + + Y+ ++I CNF+Q+ K T
Sbjct: 846 LLIFLPIGVAICIMPLCQSGDCANVILNYRLAFSYVTILAIFAHCNFSQLAAWPKTTAAV 905
Query: 272 LY-----AGVFLFVTFLGCHEVNTQYLDGDIKLYPQFLAQNLTDYFYPNDNTSDRSENNN 326
AGVF + F H V Q + + + L +Y ++TS R
Sbjct: 906 FIGLLHIAGVF-YCEFNLKHLVEEQDTCNVTAIMIPPIRKGL-NYTIALNSTSAR----- 958
Query: 327 TLNYEGMHHKXXXXXXXXXXXXXXXXXXXXNREFEISYRLSFYSNVVANRDKQRVQNMRN 386
TL+ + N +FE ++R+SF+ +V A RD +R+Q +R+
Sbjct: 959 TLSQD-FGSPLFIWELLLDVILSIVLVAFLNYQFETAFRMSFFGDVQARRDTERMQIVRD 1017
Query: 387 QADWLLHNIIPRHVADQLKNTAKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILN 446
QADWLL+N+IP H + LK KYSENH+ V ++FASI N+N+MY+E++ G+E+LR+LN
Sbjct: 1018 QADWLLNNVIPAHAVESLKTDTKYSENHETVGVLFASITNWNDMYEENFEGGREFLRVLN 1077
Query: 447 ELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQ 506
E+I DFDELL+RP F H+EKIKTIG +MAASGLNP+ + +HLYQ++DFAL +Q
Sbjct: 1078 EVIGDFDELLDRPDFTHIEKIKTIGPAYMAASGLNPERKKNMLHPKEHLYQMVDFALAVQ 1137
Query: 507 KVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRI 566
V+ FN DL FDF+ ++G N G VTAGVIGTTKLYYDIWGD VNIASRM STGV RI
Sbjct: 1138 HVLSVFNEDLLNFDFVCKLGLNIGPVTAGVIGTTKLYYDIWGDTVNIASRMYSTGVLNRI 1197
Query: 567 QVGEACVPVLSARYEFEPRGSVYVKGKD-DMNVYLLVGKK 605
QV + L RYEFE R + VKG D M+ YLLVG+K
Sbjct: 1198 QVSQHTREYLLDRYEFEFRDHIEVKGIDGGMDTYLLVGRK 1237
Score = 79.4 bits (187), Expect = 3e-13
Identities = 50/168 (29%), Positives = 88/168 (52%), Gaps = 13/168 (7%)
Query: 416 DVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFM 475
+V+I+FA I F +M S E + +LN+L FD L + + +EKI T+G +
Sbjct: 317 NVSILFADIAGFTKM--SSNKSADELVNLLNDLFGRFDTLC---RLRGLEKISTLGDCYY 371
Query: 476 AASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAG 535
+G P+ DH + ++ L+M + F+ D + + +R+G + G V G
Sbjct: 372 CVAGC-PE------PCDDHACRTVEMGLDMIVAIRQFDIDRGQ-EVNMRVGIHTGKVMCG 423
Query: 536 VIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFE 583
++GT + +D++ + V +A+ M+S+GV R+ V EA +L YE E
Sbjct: 424 MVGTKRFKFDVFSNDVTLANEMESSGVAGRVHVSEATAKLLKGLYEIE 471
>UniRef50_A7RN58 Cluster: Predicted protein; n=2; Nematostella
vectensis|Rep: Predicted protein - Nematostella vectensis
Length = 1100
Score = 263 bits (644), Expect = 1e-68
Identities = 128/250 (51%), Positives = 177/250 (70%), Gaps = 2/250 (0%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHKD 416
NR+ E+ R +F + A + K++ Q + QADWLL ++ P+HV++ LK + YS N+ +
Sbjct: 846 NRQLEMGVRRNFSGDAEAAKVKKKSQVHKQQADWLLLSLFPKHVSEALKTSDHYSMNYNN 905
Query: 417 VAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTI-GSTFM 475
++FASI+NF++ Y+E++ GKE +R+LNEL+ DFDELL+ ++ VEKIKT+ GSTFM
Sbjct: 906 AGVMFASIVNFSDFYEENFEGGKECIRVLNELVGDFDELLDNIEYMEVEKIKTVNGSTFM 965
Query: 476 AASGLNP-DLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTA 534
A +GLN D Y+HL QL++FALEM VVD FN + F F LRIG+N G VTA
Sbjct: 966 AGAGLNQEDNIRREIHPYEHLKQLVEFALEMFNVVDRFNEHMLGFKFKLRIGFNAGPVTA 1025
Query: 535 GVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKD 594
GVIGTTKL YDIWGD VN+ASRMDSTGVP++IQV E+ +L+ + FE RG++ VKGK
Sbjct: 1026 GVIGTTKLLYDIWGDTVNLASRMDSTGVPEKIQVSESTKEMLNDFFIFERRGTIPVKGKG 1085
Query: 595 DMNVYLLVGK 604
+ YL +G+
Sbjct: 1086 YVTTYLYLGR 1095
Score = 100 bits (240), Expect = 1e-19
Identities = 57/193 (29%), Positives = 102/193 (52%), Gaps = 14/193 (7%)
Query: 415 KDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTF 474
++V+I+FA I+ F +M S + +R+LN+L FD L E + H EKI T+G +
Sbjct: 288 ENVSILFADIVGFTKM--SSNKSADQLVRLLNDLFGRFDRLTE---YNHCEKISTLGDCY 342
Query: 475 MAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTA 534
+G + T +H ++ L+M + + F++D + D +R+G + G V
Sbjct: 343 YCVAG-------CPKPTPNHATYCVEMGLDMLEQIKEFDNDT-DNDVDMRVGVHTGTVLC 394
Query: 535 GVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFE-PRGSVYVKGK 593
G++GT + +D+W + V +A+RM++ G+P R+ + EA V L +Y E G
Sbjct: 395 GIVGTKRFKFDVWSNDVTLANRMETAGLPGRVHITEATVGFLRDQYIVENGHGETRNAAL 454
Query: 594 DDMNVYLLVGKKD 606
+ Y +VG+K+
Sbjct: 455 KGITTYFIVGRKN 467
Score = 79.4 bits (187), Expect = 3e-13
Identities = 57/230 (24%), Positives = 106/230 (46%), Gaps = 22/230 (9%)
Query: 55 QKLRKQSDLQLIRCVQDNARSGINYFVQPPINRFTLCFESDEMERHYRDKAHRSDDCEDL 114
+ LR +D QL+ + + G YF P++ TL F E+E+ Y+++ S
Sbjct: 596 ETLRTSNDQQLVHLMSEQG-VGDEYF-HAPVSTCTLQFYDKELEQQYQNEGQDSTLLNPS 653
Query: 115 PPTLTTSRFNTALDILVSALIFLAVSASAFVT---CSDWWRIVGWFAFFAVIELVAIALC 171
T + + N D+L+S ++F + F+ S ++ AF ++E+ L
Sbjct: 654 VTTFASPKVNFFTDVLLSNIVFFTICVLCFLLFNPVSLSMMVLTPLAF--IVEITLFFLN 711
Query: 172 FYRHYLKWQTHHDPRSVAETFHDSLKIFRKLSDWYPWHLSGGLMISLPILIVLINF-SCE 230
F R + PR + FH +K S W+ H+ G L++ LP+ V NF C
Sbjct: 712 FARAF--------PRRFPQWFHPLVK---NTSGWFTSHIVGALLMCLPMATVFSNFMDCS 760
Query: 231 NTTLPILRGEQSFYVYLLCISIVHFCNFTQMNWLAKNTLVTLYAGVFLFV 280
++F+ Y++ ++++HFCNFTQ+ K +L ++ ++ +
Sbjct: 761 QLAD---NNARNFFSYIVAVALLHFCNFTQLTSWMKTSLAAVFTMTYIIL 807
>UniRef50_Q16W55 Cluster: Adenylate cyclase; n=1; Aedes aegypti|Rep:
Adenylate cyclase - Aedes aegypti (Yellowfever mosquito)
Length = 554
Score = 209 bits (510), Expect = 2e-52
Identities = 113/249 (45%), Positives = 154/249 (61%), Gaps = 10/249 (4%)
Query: 365 RLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK------YSENHKDVA 418
R+ F + K+R +MR + + L++N++P HVA+ K YS+++ +V
Sbjct: 303 RVIFMWKTEVSDQKERASDMRRRNEALVYNVLPMHVAEHFMGNRKRSHDDLYSQSYAEVG 362
Query: 419 IIFASIINFNEMYDESYL--KGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMA 476
++FAS+ NF++ Y E + +G E LR LNE+I+DFD LLE PQFQ V KIKTIGST+MA
Sbjct: 363 VLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDVIKIKTIGSTYMA 422
Query: 477 ASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGV 536
ASGLNP + HL L++FALE++K + N F F+L++G N G +TAGV
Sbjct: 423 ASGLNPSRIDPISVRWAHLALLVEFALELKKALQGINEQSFN-HFVLKMGVNHGPITAGV 481
Query: 537 IGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSA-RYEFEPRGSVYVKGKDD 595
IG K +YDIWG+ VN+ASRM+STG IQV E +L Y FE RG V VKGK
Sbjct: 482 IGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCQILQTFGYTFEQRGLVAVKGKGQ 541
Query: 596 MNVYLLVGK 604
+ Y L GK
Sbjct: 542 LMTYYLQGK 550
>UniRef50_UPI000069E67B Cluster: Adenylate cyclase type 1 (EC
4.6.1.1) (Adenylate cyclase type I) (ATP
pyrophosphate-lyase 1) (Adenylyl cyclase 1)
(Ca(2+)/calmodulin- activated adenylyl cyclase).; n=1;
Xenopus tropicalis|Rep: Adenylate cyclase type 1 (EC
4.6.1.1) (Adenylate cyclase type I) (ATP
pyrophosphate-lyase 1) (Adenylyl cyclase 1)
(Ca(2+)/calmodulin- activated adenylyl cyclase). -
Xenopus tropicalis
Length = 781
Score = 207 bits (505), Expect = 8e-52
Identities = 114/259 (44%), Positives = 158/259 (61%), Gaps = 10/259 (3%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-----KNTAKYS 411
+R+ ++ RL + V A ++ ++ ++ +L N++P HVA +N Y
Sbjct: 522 SRQVDLKLRLDYLWAVQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLMSNPRNMDLYY 581
Query: 412 ENHKDVAIIFASIINFNEMYDE--SYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
+++ V ++FASI NFN+ Y E G E LR+LNE+IADFDEL+E+ ++ +EKIKT
Sbjct: 582 QSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKECYKDIEKIKT 641
Query: 470 IGSTFMAASGLNPDL-RHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYN 528
IGST+M A GL P A + Y HL L DF++EM V+D N+ + +F+LR+G N
Sbjct: 642 IGSTYMGAVGLVPTTGTKAKKSIYSHLSTLADFSIEMFDVLDEINYQSYN-EFVLRVGIN 700
Query: 529 FGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-SARYEFEPRGS 587
G V AGVIG + YDIWG+ VN+ASRMDSTGV +IQV E +L S YEF RG
Sbjct: 701 VGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGKIQVTEDVHRILKSCNYEFVCRGK 760
Query: 588 VYVKGKDDMNVYLLVGKKD 606
V VKGK +M Y L GK D
Sbjct: 761 VSVKGKGEMLTYFLEGKID 779
Score = 85.0 bits (201), Expect = 5e-15
Identities = 49/167 (29%), Positives = 86/167 (51%), Gaps = 13/167 (7%)
Query: 418 AIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAA 477
+I+FA I+ F + S +E +++LNEL FDEL H +IK +G +
Sbjct: 1 SILFADIVGFTSL--ASQCTAQELVKLLNELFGKFDELATE---NHCRRIKILGDCYYCV 55
Query: 478 SGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVI 537
SGL ++ DH + ++ L+M + + + E D +R+G + G V GV+
Sbjct: 56 SGL-------TQPKTDHAHCCVEMGLDMIDTITSVA-EATEVDLNMRVGLHTGRVLCGVL 107
Query: 538 GTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP 584
G K YD+W + V +A+ M++ G+P ++ + + + L+ YE EP
Sbjct: 108 GLRKWQYDVWSNDVTLANVMEAGGLPGKVHITKNTLECLNGDYEVEP 154
>UniRef50_UPI000069E679 Cluster: Adenylate cyclase type 1 (EC
4.6.1.1) (Adenylate cyclase type I) (ATP
pyrophosphate-lyase 1) (Adenylyl cyclase 1)
(Ca(2+)/calmodulin- activated adenylyl cyclase).; n=2;
Xenopus tropicalis|Rep: Adenylate cyclase type 1 (EC
4.6.1.1) (Adenylate cyclase type I) (ATP
pyrophosphate-lyase 1) (Adenylyl cyclase 1)
(Ca(2+)/calmodulin- activated adenylyl cyclase). -
Xenopus tropicalis
Length = 953
Score = 207 bits (505), Expect = 8e-52
Identities = 114/259 (44%), Positives = 158/259 (61%), Gaps = 10/259 (3%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-----KNTAKYS 411
+R+ ++ RL + V A ++ ++ ++ +L N++P HVA +N Y
Sbjct: 694 SRQVDLKLRLDYLWAVQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLMSNPRNMDLYY 753
Query: 412 ENHKDVAIIFASIINFNEMYDE--SYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
+++ V ++FASI NFN+ Y E G E LR+LNE+IADFDEL+E+ ++ +EKIKT
Sbjct: 754 QSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKECYKDIEKIKT 813
Query: 470 IGSTFMAASGLNPDL-RHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYN 528
IGST+M A GL P A + Y HL L DF++EM V+D N+ + +F+LR+G N
Sbjct: 814 IGSTYMGAVGLVPTTGTKAKKSIYSHLSTLADFSIEMFDVLDEINYQSYN-EFVLRVGIN 872
Query: 529 FGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-SARYEFEPRGS 587
G V AGVIG + YDIWG+ VN+ASRMDSTGV +IQV E +L S YEF RG
Sbjct: 873 VGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGKIQVTEDVHRILKSCNYEFVCRGK 932
Query: 588 VYVKGKDDMNVYLLVGKKD 606
V VKGK +M Y L GK D
Sbjct: 933 VSVKGKGEMLTYFLEGKID 951
Score = 99.1 bits (236), Expect = 3e-19
Identities = 61/218 (27%), Positives = 112/218 (51%), Gaps = 23/218 (10%)
Query: 377 DKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK----------YSENHKDVAIIFASIIN 426
D+ R+++ + + LL +++PR+VA ++K Y + H +V+I+FA I+
Sbjct: 100 DRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVG 159
Query: 427 FNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRH 486
F + S +E +++LNEL FDEL H +IK +G + SGL
Sbjct: 160 FTSL--ASQCTAQELVKLLNELFGKFDELATE---NHCRRIKILGDCYYCVSGL------ 208
Query: 487 ASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDI 546
++ DH + ++ L+M + + + E D +R+G + G V GV+G K YD+
Sbjct: 209 -TQPKTDHAHCCVEMGLDMIDTITSVA-EATEVDLNMRVGLHTGRVLCGVLGLRKWQYDV 266
Query: 547 WGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP 584
W + V +A+ M++ G+P ++ + + + L+ YE EP
Sbjct: 267 WSNDVTLANVMEAGGLPGKVHITKNTLECLNGDYEVEP 304
>UniRef50_A7RRQ7 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella vectensis
Length = 1052
Score = 207 bits (505), Expect = 8e-52
Identities = 114/250 (45%), Positives = 157/250 (62%), Gaps = 11/250 (4%)
Query: 365 RLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL------KNTAKYSENHKDVA 418
RL F + A +K+ ++ +R LL+NI+P HVA KN Y ++ VA
Sbjct: 797 RLDFLWKLQATEEKKEMEQLREYNKKLLYNILPVHVAQHFLGHKANKNEDLYYQSCDKVA 856
Query: 419 IIFASIINFNEMYDESYLKGK--EYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMA 476
++F++I NF++ Y E G+ E LR+LNE++ADFDELL PQFQ +EKIKTIG T+MA
Sbjct: 857 VMFSNICNFSDFYTELDANGEGVECLRLLNEILADFDELLSEPQFQCIEKIKTIGETYMA 916
Query: 477 ASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGV 536
ASG+ P+ + T +H+ + DFA+ M++ +++ N F +F ++IG NFG V AGV
Sbjct: 917 ASGIKPESQE-KLATLNHICTMADFAMAMKRKLEDINLHSFN-NFAMKIGLNFGPVVAGV 974
Query: 537 IGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSVYVKGKDD 595
IG K YDIWGD VN+ASRM STG IQV +A +LS R Y F+ RG V VKGK
Sbjct: 975 IGAHKPQYDIWGDTVNVASRMYSTGKDNHIQVTKAMYEILSTRGYTFDCRGLVAVKGKGK 1034
Query: 596 MNVYLLVGKK 605
M Y L+GK+
Sbjct: 1035 MVTYWLLGKE 1044
Score = 103 bits (246), Expect = 2e-20
Identities = 70/235 (29%), Positives = 116/235 (49%), Gaps = 25/235 (10%)
Query: 361 EISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK----------- 409
EIS R +F + +Q + LL +++PR+VA ++K+ +
Sbjct: 276 EISQRQAFLETRRCIEARLTIQKENQNQERLLLSVLPRYVAMEMKDDIESGISQNSQFHK 335
Query: 410 -YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIK 468
Y + H++V+I+FA I F + S + ++ LNEL A FD+L H +IK
Sbjct: 336 IYIQRHENVSILFADIEGFTVL--SSQCTAQSLIKTLNELYARFDQLAVE---NHCLRIK 390
Query: 469 TIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYN 528
+G + SGL PD R DH + ++ L M + +F D + + +R+G +
Sbjct: 391 ILGDCYYCVSGL-PDPRP------DHAHSCIEMGLAMIDAI-SFVRDATQVNLNMRVGVH 442
Query: 529 FGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFE 583
G V +GV+G K YD+W D V IA+ M+S G+P R+ + + + L+ YE E
Sbjct: 443 MGKVHSGVLGLVKWQYDVWSDDVTIANHMESGGLPGRVHITKEVLDCLNGDYEVE 497
>UniRef50_Q5MAL0 Cluster: Adenylate cyclase; n=2; Eukaryota|Rep:
Adenylate cyclase - Aplysia californica (California sea
hare)
Length = 1339
Score = 204 bits (497), Expect = 7e-51
Identities = 118/257 (45%), Positives = 157/257 (61%), Gaps = 15/257 (5%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL------KNTAKY 410
NRE E + RL F A +K +Q ++ Q +L N++P HVA+ + Y
Sbjct: 837 NREQEWTLRLDFLWKSQAAEEKAGMQELQRQNSRILCNLLPEHVANHFLHLQTNSHMELY 896
Query: 411 SENHKDVAIIFASIINFNEMYDE--SYLKGKEYLRILNELIADFDELLERPQFQHVEKIK 468
S+ + VA+ FASI NF++ Y E + +G E LR+LNE+IADFDELL+ P F VEKIK
Sbjct: 897 SQQYNKVAVFFASIPNFSDFYVELAANNQGVECLRVLNEIIADFDELLDIPYFYGVEKIK 956
Query: 469 TIGSTFMAASGLNPDLRHASRGTYD----HLYQLMDFALEMQKVVDNFNHDLFEFDFILR 524
TIGS +MAA+GL P H +G D +L L+DF + M++ + N N + + +F LR
Sbjct: 957 TIGSCYMAATGLKPT--HLVKGREDSITFYLTMLVDFVMSMKEKLKNINENSYN-NFELR 1013
Query: 525 IGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP 584
+G N G V AGVIG K YDIWG+ VN+ASRM+STGV +IQV E VL + + FE
Sbjct: 1014 VGINVGPVVAGVIGARKPQYDIWGNTVNVASRMESTGVSSKIQVTEEVYAVLKSVFTFEC 1073
Query: 585 RGSVYVKGKDDMNVYLL 601
RG V VKGK DM Y L
Sbjct: 1074 RGKVPVKGKGDMITYFL 1090
Score = 87.0 bits (206), Expect = 1e-15
Identities = 59/214 (27%), Positives = 109/214 (50%), Gaps = 23/214 (10%)
Query: 381 VQNMRNQADWLLHNIIPRHVADQLKNTAK----------YSENHKDVAIIFASIINFNEM 430
+Q+ + + +L +++P+HVA ++KN Y + H +V I+FA I+ F +
Sbjct: 252 IQDQNEKLERILMSVLPQHVAMEMKNDITTPHHGMFHKIYIQLHDNVTILFADIVGFTCL 311
Query: 431 YDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRG 490
S +E +RILNEL FD+L ++ + +IK +G + SGL P+ R
Sbjct: 312 --SSQCTAQELVRILNELFGRFDQLAKQ---NNCMRIKILGDCYYCVSGL-PEARA---- 361
Query: 491 TYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDA 550
+H ++ L+M + + D +R+G + G V GV+G K YD++ +
Sbjct: 362 --NHAACCVEMGLDMIDAIASVC-DQTGVKLNMRVGLHTGRVLCGVLGLKKWQYDVFSND 418
Query: 551 VNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP 584
V +A+ M++ G+ R+ + ++ + L +YE EP
Sbjct: 419 VKLANHMEAGGIAGRVHITKSTLDQLHGQYEVEP 452
>UniRef50_Q4RR06 Cluster: Chromosome 14 SCAF15003, whole genome
shotgun sequence; n=7; Clupeocephala|Rep: Chromosome 14
SCAF15003, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 1077
Score = 203 bits (495), Expect = 1e-50
Identities = 114/243 (46%), Positives = 159/243 (65%), Gaps = 10/243 (4%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVA----DQLKNTAK-YSE 412
R++E + RL F + A ++ + ++ +R + LL+NI+P HVA D+ KN + YS+
Sbjct: 782 RQWEATARLDFLWRLQAQQEVEDMRELREHNECLLYNILPVHVARHFLDRSKNDEELYSQ 841
Query: 413 NHKDVAIIFASIINFNEMYDESYLK--GKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
++ +V ++FASI FNE +++ +K G + LR+LNE+IA FDELLE F +VEKIKTI
Sbjct: 842 SYDEVGVMFASIAGFNEYFEQKEIKHEGVDCLRLLNEIIAGFDELLEESYFSYVEKIKTI 901
Query: 471 GSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFG 530
GS +MAASGL PD R S ++HL +L+ FAL MQ+ + N + +F LR+G G
Sbjct: 902 GSCYMAASGLAPD-RQVSMDEWNHLSELVLFALAMQETLKEINRHSTK-NFQLRVGIAHG 959
Query: 531 DVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSA-RYEFEPRGSVY 589
V AGVIG TK YDIWG VN+ASRMDSTGV RIQV EA +L+ + E RG ++
Sbjct: 960 PVVAGVIGATKPQYDIWGSTVNLASRMDSTGVSGRIQVPEATKKILTEWGFVLELRGEIF 1019
Query: 590 VKG 592
VKG
Sbjct: 1020 VKG 1022
Score = 75.4 bits (177), Expect = 4e-12
Identities = 57/190 (30%), Positives = 90/190 (47%), Gaps = 19/190 (10%)
Query: 418 AIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAA 477
+I+FA I F + L ++ +R LNEL FD L E H +IK +G +
Sbjct: 302 SILFADIKGFTLL--SMNLSAQDLVRTLNELFGRFDRLAEE---HHCLRIKILGDCYYCV 356
Query: 478 SGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVI 537
SG+ P+ + A H ++ L M + L +F+ +RIG + G V GV+
Sbjct: 357 SGV-PEPQRA------HARHCVEMGLAMINTIRYVRKQL-KFEVDMRIGIHSGSVLCGVL 408
Query: 538 GTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMN 597
G K +D+W V IA+ +++ G+P RI + A + L Y+ E +G+ D N
Sbjct: 409 GLQKWQFDVWSWDVGIANMLEAGGIPGRIHISRATLDCLEGTYKTEDG-----RGR-DRN 462
Query: 598 VYLLVGKKDT 607
+LL DT
Sbjct: 463 EFLLKHNIDT 472
>UniRef50_Q08828 Cluster: Adenylate cyclase type 1 (EC 4.6.1.1)
(Adenylate cyclase type I) (ATP pyrophosphate-lyase 1)
(Adenylyl cyclase 1) (Ca(2+)/calmodulin- activated
adenylyl cyclase); n=27; Euteleostomi|Rep: Adenylate
cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I)
(ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1)
(Ca(2+)/calmodulin- activated adenylyl cyclase) - Homo
sapiens (Human)
Length = 1119
Score = 202 bits (493), Expect = 2e-50
Identities = 114/258 (44%), Positives = 155/258 (60%), Gaps = 10/258 (3%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-----KNTAKYSE 412
R+ +I RL + A +++ ++ ++ +L N++P HVA +N Y +
Sbjct: 803 RQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQ 862
Query: 413 NHKDVAIIFASIINFNEMYDE--SYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
++ V ++FASI NFN+ Y E G E LR+LNE+IADFDEL+E+ ++ +EKIKTI
Sbjct: 863 SYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTI 922
Query: 471 GSTFMAASGLNPDL-RHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
GST+MAA GL P A + HL L DFA+EM V+D N+ + DF+LR+G N
Sbjct: 923 GSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFDVLDEINYQSYN-DFVLRVGINV 981
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-SARYEFEPRGSV 588
G V AGVIG + YDIWG+ VN+ASRMDSTGV RIQV E +L Y F RG V
Sbjct: 982 GPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPYHFVCRGKV 1041
Query: 589 YVKGKDDMNVYLLVGKKD 606
VKGK +M Y L G+ D
Sbjct: 1042 SVKGKGEMLTYFLEGRTD 1059
Score = 101 bits (242), Expect = 6e-20
Identities = 65/234 (27%), Positives = 117/234 (50%), Gaps = 23/234 (9%)
Query: 361 EISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK----------Y 410
E S R +F D+ R+++ + + LL +++PR+VA ++K Y
Sbjct: 236 ERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIY 295
Query: 411 SENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
+ H +V+I+FA I+ F + S +E +++LNEL FDEL H +IK +
Sbjct: 296 IQRHDNVSILFADIVGFTGL--ASQCTAQELVKLLNELFGKFDELATE---NHCRRIKIL 350
Query: 471 GSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFG 530
G + SGL ++ DH + ++ L+M + + + E D +R+G + G
Sbjct: 351 GDCYYCVSGL-------TQPKTDHAHCCVEMGLDMIDTITSVA-EATEVDLNMRVGLHTG 402
Query: 531 DVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP 584
V GV+G K YD+W + V +A+ M++ G+P ++ + + + L+ YE EP
Sbjct: 403 RVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEP 456
>UniRef50_UPI0000D56083 Cluster: PREDICTED: similar to CG10564-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG10564-PA - Tribolium castaneum
Length = 1551
Score = 199 bits (485), Expect = 2e-49
Identities = 110/257 (42%), Positives = 159/257 (61%), Gaps = 10/257 (3%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK-----YSE 412
R E++ RL F A R+ ++ R+ LL NI+P HVA + + YS+
Sbjct: 1054 RLVEVTSRLDFLWKQQAERELNDMEETRHTNTQLLKNILPDHVAQHFLSNERNSEELYSQ 1113
Query: 413 NHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIG- 471
+ ++V ++FASI NF E Y E KG E +R+LNE+IADFDELL+ +F +EKIKT+
Sbjct: 1114 SREEVGVLFASIPNFTEFYSEDINKGLECIRLLNEIIADFDELLDEERFSMIEKIKTVSA 1173
Query: 472 -STFMAASGLNPDLRHA-SRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
+T+MAASGLNP + A + + +HL L+DFA+ M++ +D N + F +F LR+G +
Sbjct: 1174 TATYMAASGLNPTHKDALNTDSPEHLCALIDFAIAMRQKLDEINKESFN-NFGLRVGVSC 1232
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSV 588
G + GVIG K +DIWG+ VN ASRMDSTGV +IQV + +L R YE + RG +
Sbjct: 1233 GSLVCGVIGARKPVFDIWGNTVNEASRMDSTGVIGQIQVPKYTAQLLGVRGYEVKKRGII 1292
Query: 589 YVKGKDDMNVYLLVGKK 605
VKGK M Y ++G++
Sbjct: 1293 EVKGKGQMETYFVMGRQ 1309
Score = 91.1 bits (216), Expect = 8e-17
Identities = 59/175 (33%), Positives = 89/175 (50%), Gaps = 13/175 (7%)
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
Y +++V+I+FA I F + S +E +RILNEL A FD+L H +IK
Sbjct: 383 YIHRYENVSILFADIKGFTAL--ASQCSAQELVRILNELFARFDKLAAE---NHCLRIKL 437
Query: 470 IGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
+G + SGL P R DH + ++ L M K + + + D +RIG +
Sbjct: 438 LGDCYYCVSGL-PTPRS------DHAHCSVEMGLHMIKAIRD-TRTKTQVDLNMRIGIHS 489
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP 584
G V GV+G K +DI+ V +A+ M+S G+P R+ + EA L+ YE EP
Sbjct: 490 GSVLCGVLGLRKWQFDIFSYDVRLANHMESGGIPGRVHISEATYQCLNGAYEVEP 544
>UniRef50_UPI0000DB7A4D Cluster: PREDICTED: similar to Adenylyl
cyclase 78C CG10564-PA; n=2; Apocrita|Rep: PREDICTED:
similar to Adenylyl cyclase 78C CG10564-PA - Apis
mellifera
Length = 1299
Score = 198 bits (483), Expect = 3e-49
Identities = 107/252 (42%), Positives = 154/252 (61%), Gaps = 6/252 (2%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK----YSEN 413
R E++ RL F A R+ + R+ LL NI+P HVA + YS++
Sbjct: 1010 RLVEVTSRLDFLWKQQAERELSDMIESRHNNMQLLKNILPDHVAHHFLTQDRAPELYSQS 1069
Query: 414 HKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGST 473
V ++FAS+ NF E Y E KG E +R+LNE+IADFDELL+ +F +EKIKT+G+T
Sbjct: 1070 RDKVGVMFASVPNFTEFYSEDVNKGMECIRLLNEIIADFDELLDENRFHCIEKIKTVGAT 1129
Query: 474 FMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVT 533
+MAASGLNP ++ +HL +L+D+A+ M+ +++ N F +F LR+G + G +
Sbjct: 1130 YMAASGLNPCQNDKNKDDMEHLCRLVDYAVAMRLRLEDVNIHSFN-NFDLRVGISCGPLV 1188
Query: 534 AGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSVYVKG 592
GVIG K +DIWG+ VN+ASRMDSTGV +IQV + L +R Y+ + RG + VKG
Sbjct: 1189 GGVIGARKPVFDIWGNTVNLASRMDSTGVMGKIQVPQDIARFLESRGYQTQKRGLIEVKG 1248
Query: 593 KDDMNVYLLVGK 604
K M Y ++GK
Sbjct: 1249 KGTMETYFVLGK 1260
Score = 89.8 bits (213), Expect = 2e-16
Identities = 67/239 (28%), Positives = 115/239 (48%), Gaps = 32/239 (13%)
Query: 365 RLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-----KNTAK---------- 409
R +F + +QR QN N+ + LL +++P VA ++ + TA+
Sbjct: 312 RQAFLETHRSMETRQRTQNENNRQEKLLLSVLPDFVAKEMIRDIARETARGGTISFTPNQ 371
Query: 410 ----YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVE 465
Y +++V+I+FA I F + S +E +++LN+L A FD+L H
Sbjct: 372 FHRIYIHRYENVSILFADIKGFTAL--ASQCSAQELVKVLNDLFARFDKLSAE---NHCL 426
Query: 466 KIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRI 525
+IK +G + GL P R DH + ++ L M K + + + + D +RI
Sbjct: 427 RIKLLGDCYYCICGL-PIARS------DHAHCCVEMGLHMIKAIRDVRYTT-KVDLNMRI 478
Query: 526 GYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP 584
G + G V GV+G K +D+W V +A+ ++S G+P R+ + E + L+ YE EP
Sbjct: 479 GIHSGSVLCGVLGLRKWQFDVWSYDVTLANHLESGGIPGRVHISEDTLNCLNDVYEVEP 537
>UniRef50_O95622 Cluster: Adenylate cyclase type 5; n=41;
Deuterostomia|Rep: Adenylate cyclase type 5 - Homo
sapiens (Human)
Length = 1261
Score = 198 bits (482), Expect = 5e-49
Identities = 115/254 (45%), Positives = 158/254 (62%), Gaps = 11/254 (4%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-----KNTAKYSE 412
++ E + RL F + A +K+ ++ ++ LLHNI+P+ VA +N Y +
Sbjct: 1006 QQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQ 1065
Query: 413 NHKDVAIIFASIINFNEMYDE--SYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
+ + VA++FASI NF+E Y E + +G E LR+LNE+IADFDE++ +F+ +EKIKTI
Sbjct: 1066 SCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTI 1125
Query: 471 GSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFG 530
GST+MAASGLN D + G H+ L DFA+++ + N F +F ++IG N G
Sbjct: 1126 GSTYMAASGLN-DSTYDKVGK-THIKALADFAMKLMDQMKYINEHSFN-NFQMKIGLNIG 1182
Query: 531 DVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSVY 589
V AGVIG K YDIWG+ VN+ASRMDSTGVP RIQV VL+A Y+ E RG V
Sbjct: 1183 PVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVK 1242
Query: 590 VKGKDDMNVYLLVG 603
VKGK +M Y L G
Sbjct: 1243 VKGKGEMMTYFLNG 1256
Score = 93.5 bits (222), Expect = 1e-17
Identities = 68/235 (28%), Positives = 116/235 (49%), Gaps = 24/235 (10%)
Query: 361 EISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKN--TAK--------- 409
E+S R +F + + Q Q + LL +++PRHVA ++K AK
Sbjct: 401 EVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKI 460
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
Y + H +V+I+FA I F + S +E + LNEL A FD+L H +IK
Sbjct: 461 YIQKHDNVSILFADIEGFTSL--ASQCTAQELVMTLNELFARFDKLAAE---NHCLRIKI 515
Query: 470 IGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
+G + SGL P+ R DH + ++ ++M + + + ++ + +R+G +
Sbjct: 516 LGDCYYCVSGL-PEARA------DHAHCCVEMGMDMIEAI-SLVREVTGVNVNMRVGIHS 567
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP 584
G V GV+G K +D+W + V +A+ M++ G RI + +A + L+ YE EP
Sbjct: 568 GRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEP 622
>UniRef50_UPI00005A2FB4 Cluster: PREDICTED: similar to brain adenylate
cyclase 1; n=1; Canis lupus familiaris|Rep: PREDICTED:
similar to brain adenylate cyclase 1 - Canis familiaris
Length = 1161
Score = 197 bits (480), Expect = 8e-49
Identities = 110/257 (42%), Positives = 154/257 (59%), Gaps = 11/257 (4%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-----KNTAKYSE 412
R+ ++ RL + A ++ ++ ++ +L N++P HVA +N Y +
Sbjct: 836 RQVDVKLRLDYLWTAQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLMSNPRNMDLYYQ 895
Query: 413 NHKDVAIIFASIINFNEMYDE--SYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
++ V ++FASI NF++ Y E G E LR+LNE+IADFDEL+++ ++ +EKIKTI
Sbjct: 896 SYSQVGVMFASIPNFDDFYIELDGNNMGVECLRLLNEIIADFDELMDKDFYKDLEKIKTI 955
Query: 471 GSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFG 530
GST+MAA GL P ++ HL L DFA+EM V+D N+ + DF+LR+G N G
Sbjct: 956 GSTYMAAVGLAPTT--GTKCISSHLSTLADFAIEMFDVLDEINYQSYN-DFVLRVGINVG 1012
Query: 531 DVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-SARYEFEPRGSVY 589
V AGVIG + YDIWG+ VN+ASRMDSTGV RIQV E +L Y F RG V
Sbjct: 1013 PVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRGTYRFVCRGKVS 1072
Query: 590 VKGKDDMNVYLLVGKKD 606
VKGK +M Y L G+ D
Sbjct: 1073 VKGKGEMLTYFLEGRTD 1089
Score = 82.2 bits (194), Expect = 4e-14
Identities = 48/165 (29%), Positives = 83/165 (50%), Gaps = 13/165 (7%)
Query: 419 IIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAAS 478
I+FA I+ F + S +E +++LNEL FDEL H +IK +G + S
Sbjct: 229 ILFADIVGFTGL--ASQCTAQELVKLLNELFGKFDELATE---NHCRRIKILGDCYYCVS 283
Query: 479 GLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIG 538
GL ++ DH + ++ L+M + + + E D +R+G + G V GV+G
Sbjct: 284 GL-------TQPKTDHAHCCVEMGLDMIDTITSVA-EATEVDLNMRVGLHTGRVLCGVLG 335
Query: 539 TTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFE 583
K YD+W + V +A+ M++ G+P ++ + + L+ YE E
Sbjct: 336 LRKWQYDVWSNDVTLANVMEAAGLPGKVHITRTTLACLNGDYEVE 380
>UniRef50_UPI0000D5745B Cluster: PREDICTED: similar to CG32158-PB,
isoform B; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG32158-PB, isoform B - Tribolium castaneum
Length = 1333
Score = 196 bits (479), Expect = 1e-48
Identities = 114/255 (44%), Positives = 155/255 (60%), Gaps = 11/255 (4%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK-----YSE 412
++ E +YRL F + A +K+ ++++ LL NI+P HVA+ N+ K Y E
Sbjct: 1040 QQTEATYRLDFVWKLQATEEKEDMEHLEAYNRKLLANILPVHVAEHFLNSDKNNDELYHE 1099
Query: 413 NHKDVAIIFASIINFNEMYDE--SYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
V I+FASI NF+E Y E +G E LR+LNE+IADFDELL QF+++EKIK+
Sbjct: 1100 QCDFVCIMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEDQFKYIEKIKST 1159
Query: 471 GSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFG 530
G+T+MAASGL + Y H+ + D+AL +Q+ + N F F +RIG N G
Sbjct: 1160 GATYMAASGLTQNT--CDMQGYRHVTAMADYALRIQEQLAEVNEHSFNH-FRIRIGINVG 1216
Query: 531 DVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSVY 589
V AGVIG K YDIWG+AVN+ASRMDSTGV +IQV + +LS+R Y RG++
Sbjct: 1217 PVVAGVIGARKPQYDIWGNAVNVASRMDSTGVLDKIQVTKEVYQILSSRGYPLTCRGTIQ 1276
Query: 590 VKGKDDMNVYLLVGK 604
VKGK M Y L G+
Sbjct: 1277 VKGKGTMETYFLEGR 1291
Score = 101 bits (241), Expect = 7e-20
Identities = 67/235 (28%), Positives = 115/235 (48%), Gaps = 24/235 (10%)
Query: 361 EISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK----------- 409
E++ R +F + ++Q Q + LL +++PRHVA ++K
Sbjct: 473 EVAQRKAFLETRQCIEARLKIQRENQQQERLLLSVLPRHVAMEMKADIAGQPKEAQFHKI 532
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
Y + H++V+I+FA I F + D+ +E +RILNEL A FD L H +IK
Sbjct: 533 YIQRHENVSILFADICGFTTLSDQC--TAEELVRILNELFARFDRLAAE---HHCLRIKL 587
Query: 470 IGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
+G + SGL P+ R DH + ++ L+M + ++ + +R+G +
Sbjct: 588 LGDCYYCVSGL-PEARP------DHAHCTVEMGLDMIDAIA-LVREVMSVNVNMRVGIHT 639
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP 584
G V GV+G K +D+W + V +A+ M+S G+P R+ + + + L Y EP
Sbjct: 640 GRVHCGVLGLRKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLGNDYVVEP 694
>UniRef50_Q4STI6 Cluster: Chromosome undetermined SCAF14199, whole
genome shotgun sequence; n=3; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF14199,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 982
Score = 194 bits (474), Expect = 4e-48
Identities = 110/261 (42%), Positives = 155/261 (59%), Gaps = 18/261 (6%)
Query: 361 EISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK-----YSENHK 415
E+ R F + + K++V MR + L+ N++P HVA T K YS+++
Sbjct: 701 EVQSRKLFLWKIGVHDQKEKVFEMRRCNEALVTNMLPEHVAKHFLGTKKRDEELYSQSYS 760
Query: 416 DVAIIFASIINFNEMYDESYLK--GKEYLRILNELIADFDELLERPQFQHVEKIKTIGST 473
+ ++FASI NF++ Y E + G E LRILNE+I+DFD LL++ +F+ + KIKTIGST
Sbjct: 761 QIGVMFASIPNFSDFYTEEGINNGGIECLRILNEIISDFDSLLDKEEFRSITKIKTIGST 820
Query: 474 FMAASGLNPDLRHASRGTYD---------HLYQLMDFALEMQKVVDNFNHDLFEFDFILR 524
+MAASGL P+ + HL L DFAL M+ ++N N F +F+LR
Sbjct: 821 YMAASGLTPECHTNGYNKSEDQPLVEHWRHLSDLADFALSMKVTLNNLNKQSFN-NFMLR 879
Query: 525 IGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSA-RYEFE 583
IG N G V AGVIG K +YDIWG+ VN+ASRM+STGV IQV E C +L + F
Sbjct: 880 IGINKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEDCYDILKEYGFHFV 939
Query: 584 PRGSVYVKGKDDMNVYLLVGK 604
RG ++VKGK ++ + + GK
Sbjct: 940 RRGPIFVKGKGELLTFFMKGK 960
Score = 97.9 bits (233), Expect = 7e-19
Identities = 66/236 (27%), Positives = 117/236 (49%), Gaps = 28/236 (11%)
Query: 364 YRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL----KNTAKYSE------- 412
YR++F + K ++ Q + LL +I+P+H+AD++ KN A+ E
Sbjct: 249 YRMAFLEARRSLEVKLTLEEQSTQQEELLLSILPKHIADEMLQGMKNQAQQQEVQQQFNT 308
Query: 413 ----NHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIK 468
H++V+I+FA I+ F ++ S +E +++LNEL A FD+L + H +IK
Sbjct: 309 MYMYRHENVSILFADIVGFTQL--SSACSAQELVKLLNELFARFDKLAAK---YHQLRIK 363
Query: 469 TIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYN 528
+G + GL PD R DH + L M + ++ + + +R+G +
Sbjct: 364 ILGDCYYCICGL-PDFRD------DHAACSIMMGLAMVDAI-SYVREKTRTEVDMRVGVH 415
Query: 529 FGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP 584
G V GV+G + +D+W V +A++M+S G+P R+ + + L +E EP
Sbjct: 416 TGTVLGGVLGQKRWQFDVWSTDVTLANKMESGGIPGRVHISQTTKDSLHGEFELEP 471
>UniRef50_UPI000069F10A Cluster: Adenylate cyclase type 6 (EC
4.6.1.1) (Adenylate cyclase type VI) (ATP
pyrophosphate-lyase 6) (Adenylyl cyclase 6)
(Ca(2+)-inhibitable adenylyl cyclase).; n=2;
Coelomata|Rep: Adenylate cyclase type 6 (EC 4.6.1.1)
(Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6)
(Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl
cyclase). - Xenopus tropicalis
Length = 355
Score = 194 bits (473), Expect = 6e-48
Identities = 110/252 (43%), Positives = 159/252 (63%), Gaps = 11/252 (4%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-----KNTAKYSE 412
++ E + RL F + A +K+ ++ ++ LLHNI+P+ VA +N Y +
Sbjct: 101 QQVESTARLDFLWKLQATGEKEEMEQLQAYNRRLLHNILPKDVAAHFLAREHRNDELYYQ 160
Query: 413 NHKDVAIIFASIINFNEMYDE--SYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
+ + VA++FASI NF+E Y E + +G E LR+LNE+IADFDE++ +F+ +EKIKTI
Sbjct: 161 SCECVAVMFASICNFSEFYVELEANNEGVECLRLLNEIIADFDEIISEEKFKQLEKIKTI 220
Query: 471 GSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFG 530
GST+MAASGLN D + G H+ L D+A+++++ + N F +F ++IG N G
Sbjct: 221 GSTYMAASGLN-DTTYDKEGK-THITALADYAMKLREQMKYINEHSFN-NFQMKIGLNIG 277
Query: 531 DVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSVY 589
V AGVIG K YDIWG+ VN+ASRMDSTG+P IQV VL+A+ Y+ E RG +
Sbjct: 278 PVVAGVIGARKPQYDIWGNTVNVASRMDSTGLPDCIQVTTDLYQVLAAKGYQMECRGVIK 337
Query: 590 VKGKDDMNVYLL 601
VKGK +M Y L
Sbjct: 338 VKGKGEMTTYFL 349
>UniRef50_Q5MAL1 Cluster: Adenylate cyclase; n=1; Aplysia
californica|Rep: Adenylate cyclase - Aplysia californica
(California sea hare)
Length = 1085
Score = 194 bits (472), Expect = 8e-48
Identities = 109/251 (43%), Positives = 152/251 (60%), Gaps = 11/251 (4%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQ---LKNTAK-YSEN 413
++ E + RL F + A +K+ ++++R LL NI+P HVA +KN K Y E+
Sbjct: 823 QQVESTARLDFIWRIQAQDEKEEMESLREYNLKLLSNILPLHVAKHFLSMKNDGKLYYED 882
Query: 414 HKDVAIIFASIINFNEMYDE--SYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIG 471
+V ++FASI+NF+E Y E + +G E LR+LNE+IADFD LL +F VEKIKT+G
Sbjct: 883 INNVGVMFASIVNFSEFYMELEANNEGVECLRLLNEIIADFDTLLTHKRFFAVEKIKTVG 942
Query: 472 STFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGD 531
T+M ASGL H+ L D+ ++ ++ N + F +F++RIG N G
Sbjct: 943 QTYMCASGLTSRTNFLDM---THILALADYTFALKNQLEYINENSFN-NFVMRIGLNIGP 998
Query: 532 VTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSA-RYEFEPRGSVYV 590
V AGVIG K +YDIWG+ VN+ASRMDSTG P +IQV +LS +Y PRG V V
Sbjct: 999 VVAGVIGAKKPHYDIWGNTVNVASRMDSTGEPNKIQVTAEMYRILSKNKYSLSPRGLVRV 1058
Query: 591 KGKDDMNVYLL 601
KGK DM+ + L
Sbjct: 1059 KGKGDMHTFFL 1069
Score = 94.3 bits (224), Expect = 8e-18
Identities = 64/215 (29%), Positives = 108/215 (50%), Gaps = 24/215 (11%)
Query: 381 VQNMRNQADWLLHNIIPRHVADQLK-----NTAK------YSENHKDVAIIFASIINFNE 429
+Q + + LL +++PRHVA ++K N + Y + H +V+I+FA I F
Sbjct: 281 MQKENQKQERLLLSVLPRHVAMEMKADIAGNKKEAMFHKIYIQRHDNVSILFADICGFTA 340
Query: 430 MYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASR 489
+ S +E +++LNEL A FD L H +IK +G + SG+ PD R
Sbjct: 341 L--SSTCTAQELVQLLNELYARFDSLATE---NHCLRIKLLGDCYYCVSGM-PDPRR--- 391
Query: 490 GTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGD 549
DH + ++ L+M + + DL + +R+G + G V GV+G K +D+W +
Sbjct: 392 ---DHAHCAVEMGLDMVEAIA-LVRDLTGTNVNMRVGIHSGRVHCGVLGLYKWQFDVWSN 447
Query: 550 AVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP 584
V +A+ M+S G+P + + A L+ Y+ EP
Sbjct: 448 DVTLANHMESGGLPGHVHISSATKDYLNGDYDLEP 482
>UniRef50_Q9VV68 Cluster: CG32158-PB, isoform B; n=12; Coelomata|Rep:
CG32158-PB, isoform B - Drosophila melanogaster (Fruit
fly)
Length = 1662
Score = 193 bits (471), Expect = 1e-47
Identities = 111/257 (43%), Positives = 155/257 (60%), Gaps = 11/257 (4%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK-----YS 411
+ + E +YRL F + A +K+ +++++ LL NI+P HVA+ + K Y
Sbjct: 1036 SHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYH 1095
Query: 412 ENHKDVAIIFASIINFNEMYDE--SYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
E V I+FASI NF+E Y E +G E LR+LNE+IADFDELL +F+ +EKIK+
Sbjct: 1096 EQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKS 1155
Query: 470 IGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
G+T+MAASGL + R + H+ + D+AL++ ++ N F +F +RIG N
Sbjct: 1156 TGATYMAASGLTANT--CDRVNFSHVTAMADYALQLFDKIEEVNMHSFN-NFRMRIGINI 1212
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSV 588
G V AGVIG K YDIWG+AVN+ASRMDSTG+ IQV + +L R +E RGSV
Sbjct: 1213 GPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGFELTCRGSV 1272
Query: 589 YVKGKDDMNVYLLVGKK 605
VKGK M Y L G++
Sbjct: 1273 DVKGKGSMITYFLKGRR 1289
Score = 99.5 bits (237), Expect = 2e-19
Identities = 67/234 (28%), Positives = 114/234 (48%), Gaps = 24/234 (10%)
Query: 361 EISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK----------- 409
E + R +F + R Q Q + LL +++PRHVA ++K+
Sbjct: 473 EKAQRKAFIETRQCIEARLRTQRENQQQERLLLSVLPRHVAMEMKDDIAGQPRDTQFHKI 532
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
Y + H++V+I+FA I F + D+ +E +R+LNEL A FD L H +IK
Sbjct: 533 YIQRHENVSILFADICGFTSLSDQC--TAEELVRLLNELFARFDRLAAE---HHCLRIKL 587
Query: 470 IGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
+G + SGL P+ R DH + ++ L+M + ++ + +R+G +
Sbjct: 588 LGDCYYCVSGL-PEPRP------DHAHCAVEMGLDMIDAIA-LVREVMAVNVNMRVGIHT 639
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFE 583
G V GV+G K +D+W + V +A+ M+S G+P R+ + + + L YE E
Sbjct: 640 GRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYEVE 693
>UniRef50_O96306 Cluster: Adenylyl cyclase isoform DAC39E; n=7;
Diptera|Rep: Adenylyl cyclase isoform DAC39E - Drosophila
melanogaster (Fruit fly)
Length = 1167
Score = 193 bits (470), Expect = 1e-47
Identities = 111/263 (42%), Positives = 162/263 (61%), Gaps = 14/263 (5%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQ-LKNTAK-----YS 411
R + R+ F K+ +MR + + L++N++P HVA+ +KNT + YS
Sbjct: 835 RHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYS 894
Query: 412 ENHKDVAIIFASIINFNEMYDESYL--KGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
+++ +V ++FAS+ NF++ Y E + +G E LR LNE+I+DFD LLE PQFQ + KIKT
Sbjct: 895 QSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKT 954
Query: 470 IGSTFMAASGLNPD--LRHASRGT--YDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRI 525
IGST+MAASG+N +R+ + T + HL L++FALE++ + + N F F+L++
Sbjct: 955 IGSTYMAASGINLQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSFNH-FVLKM 1013
Query: 526 GYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSA-RYEFEP 584
G N G +TAGVIG K +YDIWG+ VN+ASRM+STG IQV E +L Y F
Sbjct: 1014 GINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQ 1073
Query: 585 RGSVYVKGKDDMNVYLLVGKKDT 607
RG V VKGK + + L GK +
Sbjct: 1074 RGLVAVKGKGQLMTFYLQGKSQS 1096
Score = 80.6 bits (190), Expect = 1e-13
Identities = 55/216 (25%), Positives = 107/216 (49%), Gaps = 23/216 (10%)
Query: 378 KQRVQNMRNQADWLLHNIIPRHVADQLKNTAK----------YSENHKDVAIIFASIINF 427
K ++ + + LL +++P+HVA +++ Y H++V+I++A I+ F
Sbjct: 253 KMVIEEQSAEQERLLLSVLPKHVAIKMREDLGSSSSEAFKKIYMSRHENVSILYADIVGF 312
Query: 428 NEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHA 487
+ S ++ +++LNEL A FD L E+ +Q + +IK +G + SG PD R
Sbjct: 313 TAI--SSTYSAQDLVKMLNELFARFDRLAEK--YQQL-RIKILGDCYYCISGA-PDERP- 365
Query: 488 SRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIW 547
DH + L M K + + +R+G + G V AG++G + +D++
Sbjct: 366 -----DHAVLCVHMGLSMVKAI-KYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVY 419
Query: 548 GDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFE 583
V +A++M+S+G R+ + + + L+ +E E
Sbjct: 420 SKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVE 455
>UniRef50_Q4RVX9 Cluster: Chromosome 9 SCAF14991, whole genome shotgun
sequence; n=3; Euteleostomi|Rep: Chromosome 9 SCAF14991,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 1208
Score = 192 bits (467), Expect = 3e-47
Identities = 110/252 (43%), Positives = 156/252 (61%), Gaps = 11/252 (4%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-----KNTAKYSE 412
++ E + RL F + A +K+ ++ ++ LLHNI+P+ VA +N Y +
Sbjct: 954 QQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQ 1013
Query: 413 NHKDVAIIFASIINFNEMYDE--SYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
+ + VA++FASI NF+E Y E + +G E LR+LNE+IADFDE++ +F+ +EKIKTI
Sbjct: 1014 SCECVAVMFASISNFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTI 1073
Query: 471 GSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFG 530
GST+MAASGLN D + G H+ L D+A+ +++ + N F +F ++IG N G
Sbjct: 1074 GSTYMAASGLN-DSTYDREGR-SHILALADYAMRLREQMKYINEHSFN-NFQMKIGLNMG 1130
Query: 531 DVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSVY 589
V AGVIG K YDIWG+ VN+ASRMDSTGVP IQV VL + Y+ + RG V
Sbjct: 1131 PVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDYIQVTTDLYHVLDSNGYKLDCRGLVK 1190
Query: 590 VKGKDDMNVYLL 601
VKGK +M Y L
Sbjct: 1191 VKGKGEMTTYFL 1202
Score = 75.4 bits (177), Expect = 4e-12
Identities = 53/190 (27%), Positives = 98/190 (51%), Gaps = 18/190 (9%)
Query: 418 AIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAA 477
+I+FA I F + S +E + LNEL A FD+L H +IK +G +
Sbjct: 385 SILFADIEGFTSL--ASQCTAQELVMTLNELFARFDKLASE---NHCLRIKILGDCYYCV 439
Query: 478 SGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVI 537
SGL P+ R DH + ++ ++M + + + ++ + +R+G + G V GV+
Sbjct: 440 SGL-PEPRA------DHAHCCVEMGVDMIEAI-SLVREVTGVNVNMRVGIHSGRVHCGVL 491
Query: 538 GTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP----RGSVYVKGK 593
G K +D+W + V +A++M++ G RI + +A + L+ YE EP + Y+K +
Sbjct: 492 GLRKWQFDVWSNDVTLANQMEAGGKAGRIHITKATLQYLNGDYEVEPGFGGERNAYLK-E 550
Query: 594 DDMNVYLLVG 603
++ +L++G
Sbjct: 551 HNIETFLVLG 560
>UniRef50_O60266 Cluster: Adenylate cyclase type 3; n=21; Theria|Rep:
Adenylate cyclase type 3 - Homo sapiens (Human)
Length = 1144
Score = 191 bits (466), Expect = 4e-47
Identities = 110/267 (41%), Positives = 156/267 (58%), Gaps = 20/267 (7%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK-----YS 411
+R E R F + + K+RV MR + L+ N++P HVA + K YS
Sbjct: 857 SRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYS 916
Query: 412 ENHKDVAIIFASIINFNEMYDESYLK--GKEYLRILNELIADFDELLERPQFQHVEKIKT 469
+ + ++ ++FAS+ NF + Y E + G E LR LNE+I+DFD LL+ P+F+ + KIKT
Sbjct: 917 QTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKT 976
Query: 470 IGSTFMAASGLNPDLR-----------HASRGTYDHLYQLMDFALEMQKVVDNFNHDLFE 518
IGST+MAASG+ PD+ + R + HL L DFAL M+ + N N+ F
Sbjct: 977 IGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFN 1036
Query: 519 FDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-S 577
+F+LRIG N G V AGVIG K +YDIWG+ VN+ASRM+STGV IQV E +L
Sbjct: 1037 -NFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILRE 1095
Query: 578 ARYEFEPRGSVYVKGKDDMNVYLLVGK 604
+ F RG ++VKGK ++ + L G+
Sbjct: 1096 YGFRFVRRGPIFVKGKGELLTFFLKGR 1122
Score = 96.7 bits (230), Expect = 2e-18
Identities = 68/246 (27%), Positives = 123/246 (50%), Gaps = 32/246 (13%)
Query: 378 KQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHKD--------------VAIIFAS 423
K ++ Q + L+ +I+P+HVAD++ K E+ KD V+I+FA
Sbjct: 265 KMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFAD 324
Query: 424 IINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPD 483
I+ F ++ S +E +++LNEL A FD+L + H +IK +G + GL PD
Sbjct: 325 IVGFTQL--SSACSAQELVKLLNELFARFDKLAAK---YHQLRIKILGDCYYCICGL-PD 378
Query: 484 LRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLY 543
R DH + L M + + ++ + + +R+G + G V GV+G +
Sbjct: 379 YRE------DHAVCSILMGLAMVEAI-SYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQ 431
Query: 544 YDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP--RGS--VYVKGKDDMNVY 599
YD+W V +A++M++ G+P R+ + ++ + L ++ EP GS Y++ K + Y
Sbjct: 432 YDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEK-GIETY 490
Query: 600 LLVGKK 605
L++ K
Sbjct: 491 LIIASK 496
>UniRef50_UPI0000DB73AC Cluster: PREDICTED: similar to Adenylyl
cyclase 76E CG7978-PA; n=1; Apis mellifera|Rep:
PREDICTED: similar to Adenylyl cyclase 76E CG7978-PA -
Apis mellifera
Length = 969
Score = 191 bits (465), Expect = 5e-47
Identities = 135/447 (30%), Positives = 216/447 (48%), Gaps = 27/447 (6%)
Query: 171 CFYRHYLKWQTHHDPRSVAETFHDSLKIFR---KLSDWYPWHLSGGLMISLPILIVLINF 227
CF ++Q + S+ F+D + F+ ++ + YPW+ I + I + I +
Sbjct: 523 CFINIKQRYQGNEGMSSITYRFNDQDQEFQYRQQIDEQYPWYFLASTTIYIMIFGIQIMY 582
Query: 228 SCENTTLPILRGEQSFYVYLLCISIVHFCNFTQMNWLAK-NTLVTLYAGVFLFVTFLGCH 286
+ I V+L S + + + K + +V+LY + +G
Sbjct: 583 LPRKVRIIIYL----ITVFLTITSSILSLLLNDIVQIDKYDIIVSLYIYTAVMSLVIGWT 638
Query: 287 EVNTQYLDGDIKLYPQFLAQNLTDYFYPNDNTSDRSENNNTLNYEGMHHKXXXXXXXXXX 346
+ +L IK F++ + + + + + + Y +H+
Sbjct: 639 HLRVDFL---IKFCIMFISIAIIIVAFSQAPIAQLHQITDAIEYYRIHY---LFQIGCLL 692
Query: 347 XXXXXXXXXXNREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKN 406
+R+ E + R F ++ V+ MR LL NI+P HVA+
Sbjct: 693 LLVCLVLHVLDRQIEYTSRTDFLWESKLKIEQDEVETMRGINKILLENILPAHVAEHFLT 752
Query: 407 TAK-----YSENHKDVAIIFASIINFNEMYDESYL--KGKEYLRILNELIADFDELLERP 459
+ Y E + +A++FASI N+ E YDE+ + +G E LR+LNE+I DFD+LL +P
Sbjct: 753 NVRAIQDLYHERYSSIAVMFASIPNYKEFYDETDINKQGLECLRLLNEIICDFDKLLLKP 812
Query: 460 QFQHVEKIKTIGSTFMAASGLNP----DLRHASRGTYDHLYQLMDFALEMQKVVDNFNHD 515
+F +EKIKTIGST+M ASGL+P D + + ++ L++FAL + ++D N +
Sbjct: 813 KFSGIEKIKTIGSTYMLASGLSPGKDTDEKELLKQENHNIIILIEFALALMTILDQINKE 872
Query: 516 LFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPV 575
F+ F LRIG N G V AGV+G K YDIWG+ VN+ASRMDS G ++QV E +
Sbjct: 873 SFQ-KFKLRIGLNHGPVIAGVVGAQKPQYDIWGNTVNVASRMDSCGEMGKVQVTEDTAKI 931
Query: 576 L-SARYEFEPRGSVYVKGKDDMNVYLL 601
L +A YE RG YVKGK + Y +
Sbjct: 932 LIAAGYELICRGPTYVKGKGTLITYFV 958
Score = 96.7 bits (230), Expect = 2e-18
Identities = 56/175 (32%), Positives = 94/175 (53%), Gaps = 13/175 (7%)
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
Y + H +V+I++A I+NF + ++ L ++ILNEL FD++ + Q +IK
Sbjct: 263 YVQRHNNVSILYADIVNFTPLSEQ--LSASSLVKILNELFGRFDQIAQDNQCM---RIKI 317
Query: 470 IGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
+G + SGL P R +H Y + L+M + F + F+ +RIG +
Sbjct: 318 LGDCYYCVSGL-PISRP------NHAYNCVTMGLQMIDAI-KFVREATGFNVDMRIGIHT 369
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP 584
G+V GV+G K +D+W D V +A+ M+S G+P R+ + +A + L R+E EP
Sbjct: 370 GNVLCGVLGLRKWQFDVWSDDVTLANHMESGGLPGRVHITKATLLQLGNRFEVEP 424
>UniRef50_P40145 Cluster: Adenylate cyclase type 8 (EC 4.6.1.1)
(Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8)
(Adenylyl cyclase 8) (Ca(2+)/calmodulin- activated
adenylyl cyclase); n=29; Euteleostomi|Rep: Adenylate
cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII)
(ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8)
(Ca(2+)/calmodulin- activated adenylyl cyclase) - Homo
sapiens (Human)
Length = 1251
Score = 190 bits (464), Expect = 7e-47
Identities = 109/259 (42%), Positives = 154/259 (59%), Gaps = 14/259 (5%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-----KNTAKYSE 412
++ E + RL F V A + ++ +R + +L NI+P HVA N YS+
Sbjct: 917 QQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQ 976
Query: 413 NHKDVAIIFASIINFNEMYDESYL--KGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
++ V ++FASI F + Y ++ + +G E LR+LNE+IADFDELL +FQ +EKIKTI
Sbjct: 977 SYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTI 1036
Query: 471 GSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFG 530
GST+MA SGL+P+ + + HL L DF+L + + + N F +F LRIG + G
Sbjct: 1037 GSTYMAVSGLSPE-KQQCEDKWGHLCALADFSLALTESIQEINKHSFN-NFELRIGISHG 1094
Query: 531 DVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSVY 589
V AGVIG K YDIWG VN+ASRMDSTGV RIQV E +L + + F+ RG +Y
Sbjct: 1095 SVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIY 1154
Query: 590 VKG----KDDMNVYLLVGK 604
VKG + + Y L+G+
Sbjct: 1155 VKGISEQEGKIKTYFLLGR 1173
Score = 91.9 bits (218), Expect = 5e-17
Identities = 58/190 (30%), Positives = 96/190 (50%), Gaps = 15/190 (7%)
Query: 394 NIIPRHVADQLKNTAKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFD 453
N+ H+ Q Y +++V+I+FA + F + + L +E +R+LNEL A FD
Sbjct: 392 NVEDEHLQHQFHRI--YIHRYENVSILFADVKGFTNL--STTLSAQELVRMLNELFARFD 447
Query: 454 ELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFN 513
L H +IK +G + SGL P+ R DH + ++ L M K + +
Sbjct: 448 RLAHE---HHCLRIKILGDCYYCVSGL-PEPRQ------DHAHCCVEMGLSMIKTI-RYV 496
Query: 514 HDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACV 573
+ D +RIG + G V GV+G K +D+W V+IA++++S G+P RI + +A +
Sbjct: 497 RSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATL 556
Query: 574 PVLSARYEFE 583
L+ Y E
Sbjct: 557 DCLNGDYNVE 566
>UniRef50_Q9VW60 Cluster: Adenylate cyclase type 2; n=2;
Sophophora|Rep: Adenylate cyclase type 2 - Drosophila
melanogaster (Fruit fly)
Length = 1307
Score = 190 bits (464), Expect = 7e-47
Identities = 111/256 (43%), Positives = 155/256 (60%), Gaps = 12/256 (4%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL----KNTAKYSE 412
+R+ E R F +++ V+ MR LL NI+P HVA ++T Y E
Sbjct: 1045 DRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFLHLERSTELYHE 1104
Query: 413 NHKDVAIIFASIINFNEMYDESYL--KGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
++ VA++FASI N+ E YDE+ + +G E LR+LNE+I DFD+LL +P+F +EKIKTI
Sbjct: 1105 SYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTI 1164
Query: 471 GSTFMAASGLNP---DLRHASRGTYDH-LYQLMDFALEMQKVVDNFNHDLFEFDFILRIG 526
ST+M ASGL P D + T +H + L++FA+ + ++D+ N + F+ F LRIG
Sbjct: 1165 ASTYMCASGLRPGKEDGATDEKRTEEHNVVILVEFAIALMSILDSINRESFQ-RFRLRIG 1223
Query: 527 YNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-SARYEFEPR 585
N G V AGVIG K YDIW + VN+ASRMDS GV R+Q E +L +A YE E R
Sbjct: 1224 LNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYECECR 1283
Query: 586 GSVYVKGKDDMNVYLL 601
G YVKGK ++ Y +
Sbjct: 1284 GLTYVKGKGNLVTYFV 1299
Score = 78.2 bits (184), Expect = 6e-13
Identities = 49/172 (28%), Positives = 85/172 (49%), Gaps = 13/172 (7%)
Query: 412 ENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIG 471
+ H +V I+FA I+NF + S L + ++ LN+L FD++ + Q +IK +G
Sbjct: 311 QRHTNVTILFADIVNFTPL--SSSLTASDLVKTLNDLFGRFDQIAQENQCL---RIKILG 365
Query: 472 STFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGD 531
+ SGL + + Q++D A+ + N D+ RIG + G+
Sbjct: 366 DCYYCVSGLPISRPQHATNCVNMGLQMID-AIRHVREATGINVDM-------RIGIHTGN 417
Query: 532 VTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFE 583
V GV+G K +D+W D V +A+ M+S GV R+ + + + L ++E E
Sbjct: 418 VLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVE 469
>UniRef50_Q7QDV4 Cluster: ENSANGP00000010056; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000010056 - Anopheles gambiae
str. PEST
Length = 881
Score = 190 bits (463), Expect = 9e-47
Identities = 108/253 (42%), Positives = 151/253 (59%), Gaps = 11/253 (4%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK-----YS 411
+R+ E + R F +++ V+ MR LL NI+P HVA + Y
Sbjct: 631 DRQGEYAARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVAQHFLKKERAVQELYH 690
Query: 412 ENHKDVAIIFASIINFNEMYDESYL--KGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
E++ VA++FASI N+ E YDE+ + +G E LR+LNE+I DFD+LL +P+F +EKIKT
Sbjct: 691 ESYSSVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKT 750
Query: 470 IGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
IGST+M ASGL P + T ++ L++FA+ + +D N + F+ F LRIG N
Sbjct: 751 IGSTYMIASGLRPGKEEGA--TEHNVVVLVEFAIALMTALDQINRESFQ-RFRLRIGLNH 807
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-SARYEFEPRGSV 588
G V AGVIG K YDIW + VN+ASRMDS GV R+QV E VL +A Y + RG +
Sbjct: 808 GPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRVQVTENTAKVLMAAGYSCDCRGPI 867
Query: 589 YVKGKDDMNVYLL 601
+VKGK + Y +
Sbjct: 868 HVKGKGILTTYFV 880
Score = 93.1 bits (221), Expect = 2e-17
Identities = 60/215 (27%), Positives = 108/215 (50%), Gaps = 26/215 (12%)
Query: 385 RNQADWLLHNIIPRHVADQLKNTAK-------------YSENHKDVAIIFASIINFNEMY 431
R Q + LL ++IP ++A ++ + + + + H +V+I++A I+NF +
Sbjct: 88 REQQEQLLLSVIPAYIAAEMADACQRAGGQTQTRFHEMHVQRHNNVSILYADIVNFTPLS 147
Query: 432 DESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGT 491
++ L + ++ LNEL FD++ + Q +IK +G + SGL H +
Sbjct: 148 EQ--LTASDLVKTLNELFGRFDQIAQENQCL---RIKILGDCYYCVSGLPVSRPHHAANC 202
Query: 492 YDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAV 551
+ Q++D A+ + FN D+ RIG + G+V GV+G K +D+W D V
Sbjct: 203 VNMGLQMID-AIRFVREATGFNVDM-------RIGIHTGNVLCGVLGLRKWQFDVWSDDV 254
Query: 552 NIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRG 586
+A+ M+S GV R+ + +A + L +E EP G
Sbjct: 255 TLANHMESGGVAGRVHITKATLDYLGDMFEVEPGG 289
>UniRef50_Q8NFM4 Cluster: Adenylate cyclase type 4; n=73;
Euteleostomi|Rep: Adenylate cyclase type 4 - Homo sapiens
(Human)
Length = 1077
Score = 190 bits (462), Expect = 1e-46
Identities = 110/256 (42%), Positives = 152/256 (59%), Gaps = 13/256 (5%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-----KNTAKYSE 412
R+ E RL F ++++ + M N LL N++P HVA Q +N Y +
Sbjct: 808 RQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQ 867
Query: 413 NHKDVAIIFASIINFNEMYDESYL--KGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
+++ V ++FAS+ +F E Y ES + +G E LR+LNE+IADFDELL +P+F VEKIKTI
Sbjct: 868 SYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTI 927
Query: 471 GSTFMAASGLN----PDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIG 526
GST+MAA+GLN D + + + HL +++FA+ + +D N F +F LR+G
Sbjct: 928 GSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFN-NFRLRVG 986
Query: 527 YNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-SARYEFEPR 585
N G V AGVIG K YDIWG+ VN+ASRM+STGV +IQV E L S Y R
Sbjct: 987 LNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGYTCYSR 1046
Query: 586 GSVYVKGKDDMNVYLL 601
G + VKGK + Y L
Sbjct: 1047 GVIKVKGKGQLCTYFL 1062
Score = 84.2 bits (199), Expect = 9e-15
Identities = 51/177 (28%), Positives = 85/177 (48%), Gaps = 13/177 (7%)
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
Y + H+ V++++A I+ F + E KE + +LNEL FD++ + + +IK
Sbjct: 265 YVKRHQGVSVLYADIVGFTRLASEC--SPKELVLMLNELFGKFDQIAKEHECM---RIKI 319
Query: 470 IGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
+G + SGL L DH + L+M + + D +R+G +
Sbjct: 320 LGDCYYCVSGLPLSLP-------DHAINCVRMGLDMCRAIRKLRAAT-GVDINMRVGVHS 371
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRG 586
G V GVIG K YD+W V +A+ M++ GVP R+ + A + +L+ Y E G
Sbjct: 372 GSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVEDAG 428
>UniRef50_Q4T405 Cluster: Chromosome 8 SCAF9864, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 8 SCAF9864, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 879
Score = 189 bits (460), Expect = 2e-46
Identities = 113/257 (43%), Positives = 154/257 (59%), Gaps = 14/257 (5%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-----KNTAKYSE 412
R+ E RL F ++ + ++ M N LL N++P HVA+ KN Y +
Sbjct: 610 RQNEYYCRLDFLWKNKFKKECEEIETMENLNRVLLENVLPAHVAEHFLARNWKNEDLYHQ 669
Query: 413 NHKDVAIIFASIINFNEMYDESYL--KGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
++ V ++FASI +F E Y ES + +G E LR+LNE+IADFDELL +P+F VEKIKTI
Sbjct: 670 SYDLVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTI 729
Query: 471 GSTFMAASGLN--PDLRHASR---GTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRI 525
GST+MAA+GLN P HAS+ Y H+ +++FA + +D N F DF LR+
Sbjct: 730 GSTYMAATGLNASPGPEHASQEHDRQYMHIGTMVEFAFALVGKLDVINKHSFN-DFKLRV 788
Query: 526 GYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-SARYEFEP 584
G N G V AGVIG K YDIWG+ VN+ASRM+STGV +IQV E +L + Y
Sbjct: 789 GINHGPVIAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETSRILQTLGYMCSC 848
Query: 585 RGSVYVKGKDDMNVYLL 601
RG + VKGK ++ Y +
Sbjct: 849 RGIINVKGKGELKTYFV 865
Score = 59.3 bits (137), Expect = 3e-07
Identities = 41/145 (28%), Positives = 66/145 (45%), Gaps = 13/145 (8%)
Query: 444 ILNELIADFDELLERPQFQHVEKIKTI-----GSTFMAASGLNPDLRHASRGTYDHLYQL 498
+L L+ +E L R F KIK + G ++ SGL L + H
Sbjct: 245 LLYNLVNQNNEHLTRTAFGLKNKIKKLFFCGGGGSYYCVSGLPESLPN-------HAKNC 297
Query: 499 MDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMD 558
+ L+M + + D D +R+G + G+V GVIG K YD+W V +A+ M+
Sbjct: 298 VKMGLDMCEAIKKVR-DATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHME 356
Query: 559 STGVPQRIQVGEACVPVLSARYEFE 583
+ GVP R+ + + L+ Y+ E
Sbjct: 357 AGGVPGRVHITSVTLEHLNGAYKVE 381
>UniRef50_Q9Y1V0 Cluster: Adenylyl cyclase 78C-L; n=4; Sophophora|Rep:
Adenylyl cyclase 78C-L - Drosophila melanogaster (Fruit
fly)
Length = 1718
Score = 188 bits (458), Expect = 4e-46
Identities = 108/248 (43%), Positives = 150/248 (60%), Gaps = 7/248 (2%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL---KNTAK-YSEN 413
R E++ RL F A R+ +++ R D L+ NI+P HVA ++T + YS+
Sbjct: 1326 RLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYLSDEHTDELYSKM 1385
Query: 414 HKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGST 473
H ++FASI NF + Y E GK +RILNE+I DFDELLE P+F VEKIKT+G+T
Sbjct: 1386 HNLCGVMFASIPNFQDFYSEDIDNGKACIRILNEIICDFDELLEEPRFASVEKIKTVGAT 1445
Query: 474 FMAASGLNPD-LRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDV 532
+MAA+GLN + LR + D + L++FA M++ ++ N D F +F LR+G G +
Sbjct: 1446 YMAAAGLNHEHLRLRGETSEDSVCDLVEFAFAMKQKLEEINGDAFN-NFQLRVGICSGPL 1504
Query: 533 TAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSVYVK 591
+GVIG K YDIWG+ VN+ASRMDSTG R+QV E +L +R Y RG + VK
Sbjct: 1505 VSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYTCVKRGEIAVK 1564
Query: 592 GKDDMNVY 599
GK M +
Sbjct: 1565 GKGMMTTF 1572
Score = 88.2 bits (209), Expect = 6e-16
Identities = 66/234 (28%), Positives = 112/234 (47%), Gaps = 23/234 (9%)
Query: 365 RLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKN--------TAKYSENH-- 414
RL+F A K+ + + LL +I+P V +Q+++ T + N
Sbjct: 508 RLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMYKGTDPTVETQFNKLY 567
Query: 415 ----KDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
+V+I+FA I F E+ ++ ++ ++ILN+L A FD + E H ++K +
Sbjct: 568 VYPMDNVSILFADIKGFTELASKT--SAQQLVKILNDLFARFDRIAED---NHCLRVKLL 622
Query: 471 GSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFG 530
G + S D +R DH ++ L M K + + D +RIG + G
Sbjct: 623 GDCYYCVSQFESD-NWKTRP--DHAVCSVETGLHMIKAIKDVRLHT-HVDLNMRIGIHSG 678
Query: 531 DVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP 584
V GV+G K ++D+W + V IA+ M+S G+P R+ + EA + L+ YE EP
Sbjct: 679 SVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEP 732
>UniRef50_Q1MU16 Cluster: ORF for hypothetical protein; n=2;
Apocrita|Rep: ORF for hypothetical protein - Apis
mellifera (Honeybee)
Length = 998
Score = 188 bits (457), Expect = 5e-46
Identities = 104/241 (43%), Positives = 151/241 (62%), Gaps = 11/241 (4%)
Query: 372 VVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK-----YSENHKDVAIIFASIIN 426
VVA R++ RN A L++NI+P HVA + A+ YS+++ +V ++FAS+ N
Sbjct: 739 VVAQRERAADMKRRNGA--LIYNILPPHVAAYFLSRARHHDDLYSQSYAEVGVLFASMPN 796
Query: 427 FNEMYDESYL--KGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDL 484
F + Y E + +G E LR LNE+I+DFD +L++ +F+ + KIKTIGST+MAASG+
Sbjct: 797 FADFYSEESINNQGLECLRFLNEVISDFDAILDQNKFKDIIKIKTIGSTYMAASGITESA 856
Query: 485 RHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYY 544
+ HL L++FALE++K + + N F F+L++G N G VTAGVIG K +Y
Sbjct: 857 ESEDGPRWGHLSTLVEFALELKKALSSINEQSFN-HFVLKMGINHGPVTAGVIGARKPHY 915
Query: 545 DIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSA-RYEFEPRGSVYVKGKDDMNVYLLVG 603
DIWG+ VN+ASRM+STG IQV + +L + FE RG V+VKGK + + LV
Sbjct: 916 DIWGNTVNVASRMESTGKVGCIQVTDETRKILEPFGFGFEQRGLVFVKGKGQLLTHYLVS 975
Query: 604 K 604
K
Sbjct: 976 K 976
Score = 83.4 bits (197), Expect = 2e-14
Identities = 58/214 (27%), Positives = 106/214 (49%), Gaps = 23/214 (10%)
Query: 381 VQNMRNQADWLLHNIIPRHVADQLKNTAK----------YSENHKDVAIIFASIINFNEM 430
++ + + LL +++P HVA +++ Y H++V+I++A I+ F +
Sbjct: 226 IEEQSTEQERLLLSVLPEHVAVKMRQDLGASLDTQFKKIYMSRHENVSILYADIVGFTAI 285
Query: 431 YDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRG 490
S E ++ILNEL A FD+L ER F+ + +IK +G + SG P R
Sbjct: 286 --SSTYSASELVKILNELFARFDQLSER--FEQL-RIKILGDCYYCISGA-PIERP---- 335
Query: 491 TYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDA 550
DH + L M + + + +R+G + G V AGV+G + +D++
Sbjct: 336 --DHAVLCVYMGLSMVEAI-KYVQQTTNSPVDMRVGIHTGAVLAGVLGQRQWQFDVYSKD 392
Query: 551 VNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP 584
V +A++M+S+G+ R+ + A + L+ +E EP
Sbjct: 393 VELANKMESSGMAGRVHISNATLSFLNGEFEVEP 426
>UniRef50_P32870 Cluster: Ca(2+)/calmodulin-responsive adenylate
cyclase; n=5; Coelomata|Rep: Ca(2+)/calmodulin-responsive
adenylate cyclase - Drosophila melanogaster (Fruit fly)
Length = 2248
Score = 188 bits (457), Expect = 5e-46
Identities = 105/256 (41%), Positives = 156/256 (60%), Gaps = 13/256 (5%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVAD-----QLKNTAK-YS 411
R E + RL F + A+++K+ + ++ +LHN++P HVA Q +N + Y
Sbjct: 897 RLVEGTARLDFLWQLQASQEKKEMDVLQESNKRILHNLLPAHVAAHFLDAQFRNNMELYH 956
Query: 412 ENHKDVAIIFASIINFNEMYDE--SYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
+++ V +IFAS+ NFNE Y E +G E LR+LNE+IADFDELL+ +F+ ++KIKT
Sbjct: 957 QSYAKVGVIFASVPNFNEFYTEMDGSDQGLECLRLLNEIIADFDELLKEDRFRGIDKIKT 1016
Query: 470 IGSTFMAASGLNPDLR---HASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIG 526
+GST+MA GL P+ + + H+ L+++ M+ + N + +F+LR+G
Sbjct: 1017 VGSTYMAVVGLIPEYKIQPNDPNSVRRHMTALIEYVKAMRHSLQEINSHSYN-NFMLRVG 1075
Query: 527 YNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACV-PVLSARYEFEPR 585
N G V AGVIG K YDIWG+ VN+ASRMDSTGVP QV + V ++ + +EF R
Sbjct: 1076 INIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYSQVTQEVVDSLVGSHFEFRCR 1135
Query: 586 GSVYVKGKDDMNVYLL 601
G++ VKGK DM Y L
Sbjct: 1136 GTIKVKGKGDMVTYFL 1151
Score = 98.7 bits (235), Expect = 4e-19
Identities = 72/225 (32%), Positives = 114/225 (50%), Gaps = 29/225 (12%)
Query: 371 NVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK----------YSENHKDVAII 420
N +A+R +Q+ + + LL +++P+HVA Q+KN Y + H++V+I+
Sbjct: 220 NCIASR--LEIQDENEKLERLLLSVLPQHVAMQMKNDILSPVAGQFHRIYIQKHENVSIL 277
Query: 421 FASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL 480
FA I+ F + S +E +R+LNEL FD+L H +IK +G + SGL
Sbjct: 278 FADIVGFTVL--SSQCSAQELVRLLNELFGRFDQLAHD---NHCLRIKILGDCYYCVSGL 332
Query: 481 NPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFIL--RIGYNFGDVTAGVIG 538
P+ R DH ++ L+M +D + D IL R+G + G V GV+G
Sbjct: 333 -PEPRK------DHAKCAVEMGLDM---IDAIATVVEATDVILNMRVGIHTGRVLCGVLG 382
Query: 539 TTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFE 583
K +D+W + V +A+ M+S G P R+ V A + LS YE E
Sbjct: 383 LRKWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDSLSGEYEVE 427
>UniRef50_UPI0000E47CE1 Cluster: PREDICTED: similar to Adenylate
cyclase 2; n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to Adenylate cyclase 2 -
Strongylocentrotus purpuratus
Length = 889
Score = 186 bits (454), Expect = 1e-45
Identities = 107/253 (42%), Positives = 156/253 (61%), Gaps = 9/253 (3%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQ-LKNTAK---YSE 412
+R E + RL F + +++ V+ M + LL N++P HVA +K K Y +
Sbjct: 620 DRRIEYTARLGFLWQMKYRVEREEVETMESLNKVLLENMLPSHVAQHFVKQRMKSDLYHQ 679
Query: 413 NHKDVAIIFASIINFNEMYDESYL--KGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
++ +A++FASI NF E Y E+ + +G E LR+LNE+IADFDELL +P++ VEKIKTI
Sbjct: 680 SYNLIAVMFASIPNFKEFYTETDVNNEGLECLRLLNEIIADFDELLSKPKYSCVEKIKTI 739
Query: 471 GSTFMAASGLN-PDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
GST+M+A+GL P+ +++ + ++ L +FA+ +Q ++ N F DF LRIG N
Sbjct: 740 GSTYMSAAGLKQPESGVSTKQSLYYVGVLTEFAMALQDKLEQLNKQAFN-DFKLRIGINH 798
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-SARYEFEPRGSV 588
G V AGVIG K YDIWG+ VN+ASRMD+TG+ IQV E VL + E RG +
Sbjct: 799 GPVVAGVIGARKPQYDIWGNTVNVASRMDTTGMIGEIQVTEETANVLMELGFTCETRGII 858
Query: 589 YVKGKDDMNVYLL 601
VKGK + Y++
Sbjct: 859 SVKGKGKLKTYIV 871
Score = 97.5 bits (232), Expect = 9e-19
Identities = 65/201 (32%), Positives = 103/201 (51%), Gaps = 16/201 (7%)
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
Y + HK+V+I++A I+ F + E E ++ LNEL FD+L E +F + +IK
Sbjct: 90 YVKRHKNVSILYADIVGFTALASEC--SPPELVKTLNELFGRFDQLAE--EFDCM-RIKI 144
Query: 470 IGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
+G + SGL SR T H ++ L M + + D D +R+G +
Sbjct: 145 LGDCYYCVSGLP-----ISRPT--HAINCVEMGLAMCEAIKTVR-DATSVDVNMRVGVHT 196
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP-RGSV 588
G+V GV+G K YD+W V +A+ M+S GVP R+ + +A + L +YE EP RG
Sbjct: 197 GNVLCGVLGLRKWQYDVWSHDVTLANHMESCGVPGRVHITQATLDNLGLKYEVEPGRGHE 256
Query: 589 YVKGKDDMNV--YLLVGKKDT 607
+ DMN+ + +V K +
Sbjct: 257 RSEYLRDMNIETFFIVNPKSS 277
>UniRef50_Q5TUN5 Cluster: ENSANGP00000027378; n=2; Culicidae|Rep:
ENSANGP00000027378 - Anopheles gambiae str. PEST
Length = 2040
Score = 186 bits (452), Expect = 2e-45
Identities = 107/257 (41%), Positives = 154/257 (59%), Gaps = 14/257 (5%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-------KNTAKY 410
R+ E + RL F + A+++K+ + ++ +L+N++P HVA N Y
Sbjct: 889 RQVEWTARLDFLWQLQASQEKKEMSVLQQSNRRILYNLLPSHVAAHFLDNQFARSNMDLY 948
Query: 411 SENHKDVAIIFASIINFNEMYDE--SYLKGKEYLRILNELIADFDELLERPQFQHVEKIK 468
+++ V +IFAS+ NF+E Y E +G E LR+LNE+IADFDELL +F ++KIK
Sbjct: 949 HQSYSKVGVIFASVPNFHEFYTELDGSNQGVECLRLLNEIIADFDELLCEERFHAIDKIK 1008
Query: 469 TIGSTFMAASGLNPD--LRHASRGTYDHLYQ-LMDFALEMQKVVDNFNHDLFEFDFILRI 525
T+GST+MAA GL P+ + + G+ L L+DF M+ + N N + + +F+LR+
Sbjct: 1009 TVGSTYMAAVGLIPEHKMLPSEPGSMRRLMTALVDFVKAMRVTLKNINENSYN-NFMLRV 1067
Query: 526 GYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-SARYEFEP 584
G N G V AGVIG K YDIWG+ VN+ASRMDSTG+P QV + V L + +EF
Sbjct: 1068 GVNVGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGIPGYTQVTQEVVDSLQGSHFEFRC 1127
Query: 585 RGSVYVKGKDDMNVYLL 601
RG + VKGK DM Y L
Sbjct: 1128 RGQIKVKGKGDMVTYFL 1144
Score = 95.9 bits (228), Expect = 3e-18
Identities = 70/225 (31%), Positives = 113/225 (50%), Gaps = 29/225 (12%)
Query: 371 NVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK----------YSENHKDVAII 420
N +A R + +N + + LL +++P+HVA ++KN Y + H++V+I+
Sbjct: 220 NCIAARLEMEDEN--EKLERLLLSVLPQHVAMEMKNDILSPVEGQFHKIYIQKHENVSIL 277
Query: 421 FASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL 480
FA I+ F + S +E +R+LNEL FD+L H +IK +G + SG+
Sbjct: 278 FADIVGFTVL--ASQCSAQELVRLLNELFGRFDQLAHD---NHCLRIKILGDCYYCVSGI 332
Query: 481 NPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFIL--RIGYNFGDVTAGVIG 538
PD R DH ++ L+M +D + + D IL R+G + G V GV+G
Sbjct: 333 -PDPRA------DHARCAVEMGLDM---IDAIASVVEQTDVILNMRVGIHSGRVLCGVLG 382
Query: 539 TTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFE 583
K +D+W + V +A+ M+S G P R+ V A + L YE E
Sbjct: 383 LRKWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDALGGEYEVE 427
>UniRef50_Q16XH3 Cluster: Adenylate cyclase; n=3; Endopterygota|Rep:
Adenylate cyclase - Aedes aegypti (Yellowfever mosquito)
Length = 1285
Score = 186 bits (452), Expect = 2e-45
Identities = 112/260 (43%), Positives = 150/260 (57%), Gaps = 18/260 (6%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK-----YS 411
+R+ E R F +++ V+ MR LL NI+P HVA + Y
Sbjct: 1017 DRQGEYVSRTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVAQHFLKKERAVQELYH 1076
Query: 412 ENHKDVAIIFASIINFNEMYDESYL--KGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
E++ VA++FASI N+ E YDE+ + +G E LR+LNE+I DFD+LL +P+F +EKIKT
Sbjct: 1077 ESYSSVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKT 1136
Query: 470 IGSTFMAASGLNPDLRHAS--------RGTYDH-LYQLMDFALEMQKVVDNFNHDLFEFD 520
IGST+M ASGL P + + T +H + L+DFA+ + +D N + F+
Sbjct: 1137 IGSTYMVASGLRPGKEEGATKNNELDEKRTEEHNVVVLVDFAIALMTALDQINRESFQ-R 1195
Query: 521 FILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-SAR 579
F LRIG N G V AGVIG K YDIW + VN+ASRMDS GV RIQV E VL +A
Sbjct: 1196 FRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRIQVSENTAKVLMAAG 1255
Query: 580 YEFEPRGSVYVKGKDDMNVY 599
Y E RG + VKGK + Y
Sbjct: 1256 YSCECRGPIPVKGKGILTTY 1275
Score = 91.5 bits (217), Expect = 6e-17
Identities = 54/175 (30%), Positives = 93/175 (53%), Gaps = 13/175 (7%)
Query: 412 ENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIG 471
+ H +V+I++A I+NF + ++ L + ++ LNEL FD++ + Q +IK +G
Sbjct: 274 QRHNNVSILYADIVNFTPLSEQ--LTASDLVKTLNELFGRFDQIAQENQCL---RIKILG 328
Query: 472 STFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGD 531
+ SGL SR H ++ L+M + + F + F+ +RIG + G+
Sbjct: 329 DCYYCVSGLP-----VSRP--QHAANCVNMGLQMIEAI-RFVREATGFNVDMRIGIHTGN 380
Query: 532 VTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRG 586
V GV+G K +D+W D V +A+ M+S GV R+ + +A + L R+E EP G
Sbjct: 381 VLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKATLDYLGDRFEVEPGG 435
>UniRef50_UPI00015A564B Cluster: Novel protein similar to vertebrate
adenylate cyclase 2 (Brain) (ADCY2); n=2; Danio
rerio|Rep: Novel protein similar to vertebrate adenylate
cyclase 2 (Brain) (ADCY2) - Danio rerio
Length = 793
Score = 185 bits (450), Expect = 3e-45
Identities = 109/249 (43%), Positives = 150/249 (60%), Gaps = 13/249 (5%)
Query: 365 RLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-----KNTAKYSENHKDVAI 419
RL F ++ + ++ M N LL N++P HVA+ KN Y +++ V +
Sbjct: 546 RLDFLWRNKFKKECEEIETMENLNRVLLENVLPAHVAEHFLGRNWKNEDLYHQSYDTVCV 605
Query: 420 IFASIINFNEMYDESYL--KGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAA 477
+FASI +F E Y ES + +G E LR+LNE+IADFDELL +P+F VEKIKTIGST+MAA
Sbjct: 606 MFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAA 665
Query: 478 SGLN--PDLRHAS--RGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVT 533
+GLN P L +A Y H+ +++FA + +D N F DF +R+G N G V
Sbjct: 666 TGLNVTPGLEYAQYHDRQYMHIGTMVEFAFALVGKLDVINKHSFN-DFRMRVGINHGPVI 724
Query: 534 AGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-SARYEFEPRGSVYVKG 592
AGVIG K YDIWG+ VN+ASRM+STGV +IQV E +L + Y RG + VKG
Sbjct: 725 AGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETNWILQTLGYMCSCRGIINVKG 784
Query: 593 KDDMNVYLL 601
K D+ + +
Sbjct: 785 KGDLRTFFV 793
Score = 81.0 bits (191), Expect = 8e-14
Identities = 49/174 (28%), Positives = 85/174 (48%), Gaps = 13/174 (7%)
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
Y + H +V+I++A I+ F + + E + +LNEL FD++ + +IK
Sbjct: 42 YVQRHTNVSILYADIVGFTRLASDC--SPGELVYMLNELFGKFDQIAKDNDCM---RIKI 96
Query: 470 IGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
+G + SGL PD DH + L+M + ++ + D +R+G +
Sbjct: 97 LGDCYYCVSGL-PD------PLLDHAKNCVKMGLDMCEAIEKVR-EATGVDINMRVGVHS 148
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFE 583
G+V GVIG K YD+W V +A+ M++ GVP R+ + + L+ Y+ E
Sbjct: 149 GNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVE 202
>UniRef50_UPI000065E155 Cluster: Adenylate cyclase type 8 (EC 4.6.1.1)
(Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8)
(Adenylyl cyclase 8) (Ca(2+)/calmodulin- activated
adenylyl cyclase).; n=4; Clupeocephala|Rep: Adenylate
cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII)
(ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8)
(Ca(2+)/calmodulin- activated adenylyl cyclase). -
Takifugu rubripes
Length = 1020
Score = 184 bits (449), Expect = 5e-45
Identities = 104/244 (42%), Positives = 150/244 (61%), Gaps = 10/244 (4%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-----KNTAKYS 411
+R E RL F + A ++ + ++ +R + LL NI+P HVA N YS
Sbjct: 770 SRTLEAMARLDFLWRLQARKEVEDMRELREHNECLLLNILPAHVAQHFLERDRNNEELYS 829
Query: 412 ENHKDVAIIFASIINFNEMYDESYLKGKEY--LRILNELIADFDELLERPQFQHVEKIKT 469
++++ V ++FAS+ F++ Y++ + + LR+LN +I DFDELL+ FQ VEKIKT
Sbjct: 830 QSYERVGVLFASLPGFSDYYEQKEAADQHFGCLRLLNHIITDFDELLDESYFQDVEKIKT 889
Query: 470 IGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
+GS++MAASGL+PD + G + HL +L+ FAL MQ+ + + N D F LR+G
Sbjct: 890 MGSSYMAASGLSPDRQECEDG-WHHLSELVLFALSMQETLKHINTDTGN-SFQLRVGIAH 947
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSV 588
G V AGVIG TK YDIWG VN+ASRM+STGV IQV E+ +L R + + RGS+
Sbjct: 948 GPVIAGVIGATKPQYDIWGTTVNVASRMESTGVSGMIQVPESTSCILVERGFLRQLRGSI 1007
Query: 589 YVKG 592
+VKG
Sbjct: 1008 FVKG 1011
Score = 79.0 bits (186), Expect = 3e-13
Identities = 53/166 (31%), Positives = 81/166 (48%), Gaps = 13/166 (7%)
Query: 418 AIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAA 477
+I+FA II F + L +E +R LNEL FD L E +IK +G +
Sbjct: 295 SILFADIIGFTSL--SLILSAQELVRTLNELFGRFDRLAEE---HRCLRIKILGDCYYCV 349
Query: 478 SGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVI 537
SG+ P+ RG H +D L M + ++ + + +RIG + G V GV+
Sbjct: 350 SGV-PE---PQRG---HARCCVDMGLSMINAIRYIRREI-QLELDMRIGVHSGSVLCGVL 401
Query: 538 GTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFE 583
G K +DIW V+IA+ +++ GVP R+ + A + L YE E
Sbjct: 402 GLQKWQFDIWSWDVDIANSLEAAGVPGRVHISRATLDCLGGIYETE 447
>UniRef50_UPI00015B5F6F Cluster: PREDICTED: similar to
ENSANGP00000010056; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000010056 - Nasonia
vitripennis
Length = 947
Score = 184 bits (448), Expect = 6e-45
Identities = 106/258 (41%), Positives = 151/258 (58%), Gaps = 14/258 (5%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL----KNTAKYSE 412
+R E + R F ++ V+ MR LL NI+P HVA +N Y E
Sbjct: 680 DRRIEYTSRTDFLWKNKLKVEQDEVETMRGINKILLENILPAHVAGHFLATRENQDLYHE 739
Query: 413 NHKDVAIIFASIINFNEMYDESYL--KGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
++ +A++FASI N+ E YDE+ + +G E LR+LNE+I DFD+LL +P++ +EKIKTI
Sbjct: 740 SYNSIAVMFASIPNYKEFYDETDINKQGLECLRLLNEIICDFDKLLLKPKYSSIEKIKTI 799
Query: 471 GSTFMAASGLNPD------LRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILR 524
GST+M A GL+P L ++ ++ L++FA+ + ++D N + F+ F LR
Sbjct: 800 GSTYMLACGLSPGKEDGDGLIDLTKQREHNVIVLVEFAISLTTLLDQINRESFQ-RFKLR 858
Query: 525 IGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-SARYEFE 583
IG N G V AGV+G K YDIWG+ VN+ASRMDS G +IQV E +L +A YE
Sbjct: 859 IGLNHGPVIAGVVGAQKPQYDIWGNTVNVASRMDSCGEMGKIQVTEDTAKILRNAGYELI 918
Query: 584 PRGSVYVKGKDDMNVYLL 601
RG YVKGK + Y +
Sbjct: 919 CRGPTYVKGKGTLTTYFV 936
Score = 96.3 bits (229), Expect = 2e-18
Identities = 55/175 (31%), Positives = 96/175 (54%), Gaps = 13/175 (7%)
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
Y + H +V+I++A I+NF + ++ L + ++ LNEL FD++ + Q +IK
Sbjct: 191 YVQRHNNVSILYADIVNFTPLSEQ--LSASDLVKTLNELFGRFDQIAQDNQCM---RIKI 245
Query: 470 IGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
+G + SGL SR +H Y ++ L+M + + F + F+ +RIG +
Sbjct: 246 LGDCYYCVSGLP-----VSRP--NHAYNCVNMGLQMIEAI-RFVREATGFNVDMRIGIHT 297
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP 584
G+V GV+G K +D+W D V +A+ M+S G+P ++ V +A + L R+E EP
Sbjct: 298 GNVLCGVLGLRKWQFDVWSDDVTLANHMESGGLPGKVHVTKATLLQLGDRFEVEP 352
>UniRef50_Q4T7J2 Cluster: Chromosome undetermined SCAF8089, whole
genome shotgun sequence; n=2; Tetraodontidae|Rep:
Chromosome undetermined SCAF8089, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 821
Score = 181 bits (441), Expect = 4e-44
Identities = 106/256 (41%), Positives = 149/256 (58%), Gaps = 13/256 (5%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVAD-----QLKNTAKYSE 412
R+ E+ R+ F + +++ ++ M N LL N++P VA ++N YS+
Sbjct: 561 RQDELGCRVDFLLDRCFQMEREEMETMENINRLLLQNVLPFDVASFFLGKTIRNQDLYSQ 620
Query: 413 NHKDVAIIFASIINFNEMYDESYLK--GKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
++ V ++FAS+ F E Y ES G E LR LNE+I+DFDELL +P+F VEKIKTI
Sbjct: 621 SYDCVCVMFASVPQFKEFYSESSANNDGLECLRFLNEIISDFDELLSKPKFSSVEKIKTI 680
Query: 471 GSTFMAASGLN----PDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIG 526
GST+MAA+GL D +Y H+ +++FA+ + ++ N F F LRIG
Sbjct: 681 GSTYMAAAGLTLAPVGDENKKVEMSYSHVRAMVEFAIALMSKLEFINKHSFNI-FKLRIG 739
Query: 527 YNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-SARYEFEPR 585
N G V AGVIG K YDIWG++VN+ASRM+STGV +IQV E ++ S Y R
Sbjct: 740 INHGPVIAGVIGAHKPQYDIWGNSVNVASRMESTGVLDKIQVTEETSQMVESVGYNVTLR 799
Query: 586 GSVYVKGKDDMNVYLL 601
G V VKGK D+ Y +
Sbjct: 800 GVVNVKGKGDLTTYFV 815
Score = 54.8 bits (126), Expect = 6e-06
Identities = 23/61 (37%), Positives = 37/61 (60%)
Query: 523 LRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEF 582
+R+G + G+V GVIG K YD+W V +A+ M+S G+P R+ + E + L+ Y+
Sbjct: 175 MRVGVHTGNVLCGVIGLQKWQYDVWSHDVTLANHMESGGLPGRVHITEETLQHLNGAYQV 234
Query: 583 E 583
E
Sbjct: 235 E 235
Score = 45.2 bits (102), Expect = 0.005
Identities = 26/79 (32%), Positives = 44/79 (55%), Gaps = 6/79 (7%)
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
Y HKDV+I++A I+ F ++ S L +E + +LN+L FD++ ++ +IK
Sbjct: 46 YIRQHKDVSILYADIVGFTKL--ASSLSPQELVAVLNKLFGRFDDIAKK---NGCLRIKI 100
Query: 470 IGSTFMAASGL-NPDLRHA 487
+G + SGL +P HA
Sbjct: 101 LGDCYYCVSGLPDPIPNHA 119
>UniRef50_UPI0000D56082 Cluster: PREDICTED: similar to adenylate
cyclase 8; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to adenylate cyclase 8 - Tribolium castaneum
Length = 912
Score = 180 bits (439), Expect = 8e-44
Identities = 104/258 (40%), Positives = 155/258 (60%), Gaps = 13/258 (5%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVAD-----QLKNTAKYSE 412
R E++ RL F A + ++ R LL N++P HVA + +N YS+
Sbjct: 620 RLIEVTSRLYFLWKHKAQIELDGMRAARQTNMQLLTNVLPEHVAKHFLSREYRNEELYSQ 679
Query: 413 NHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGS 472
+ ++FA+I NF++ Y E+ KG E LR+LNE+IA FDE+L+ +F +EKIKT+ +
Sbjct: 680 ARDGIGVLFATIPNFSKFYSEA--KGLECLRLLNEIIATFDEVLDDERFSSIEKIKTVSA 737
Query: 473 T--FMAASGLNPDLRHASR--GTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYN 528
T +MA SGLNP ++H T +HL L+DFA+ +++ ++ N D F F LR+G +
Sbjct: 738 TATYMAVSGLNPSIKHDPLIGDTPEHLGALIDFAITLRQRLEEINRDSFN-RFNLRVGIS 796
Query: 529 FGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGS 587
+GD+ GVIG K +D+WG+ VN ASRMDSTG+ IQV + +L + YE + RG
Sbjct: 797 YGDLVCGVIGAKKPIFDVWGNTVNEASRMDSTGLMGEIQVPKNTAQLLVHQGYELKKRGL 856
Query: 588 VYVKGKDDMNVYLLVGKK 605
V VKGK M + ++GKK
Sbjct: 857 VRVKGKGLMETFFVLGKK 874
Score = 83.4 bits (197), Expect = 2e-14
Identities = 58/196 (29%), Positives = 96/196 (48%), Gaps = 16/196 (8%)
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
Y + +V+I+FA I F + S +E +R LN+L A FD+L + +IK
Sbjct: 136 YIHKYNNVSILFADIKGFTAL--ASKCTAQELVRNLNDLFARFDKLATK---HDCLRIKL 190
Query: 470 IGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
+G + SGL P+ R DH ++ L M K + + + D +RIG +
Sbjct: 191 LGDCYYCVSGL-PNARE------DHADCAVEMGLNMIKAIKDTKTKT-QVDIDMRIGIHS 242
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP---RG 586
G V GV+G K +DIW V IA+RM++TG+ R+ + +A + L+ + E R
Sbjct: 243 GSVLCGVLGLRKWQFDIWSHDVKIANRMEATGIAGRVHISDATLRALTKEFRVEAAHGRE 302
Query: 587 SVYVKGKDDMNVYLLV 602
+ K+D+ Y ++
Sbjct: 303 KDSLLRKNDIQTYFIL 318
>UniRef50_UPI00015A6AA9 Cluster: Adenylate cyclase type 8 (EC
4.6.1.1) (Adenylate cyclase type VIII) (ATP
pyrophosphate-lyase 8) (Adenylyl cyclase 8)
(Ca(2+)/calmodulin- activated adenylyl cyclase).; n=1;
Danio rerio|Rep: Adenylate cyclase type 8 (EC 4.6.1.1)
(Adenylate cyclase type VIII) (ATP pyrophosphate-lyase
8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin- activated
adenylyl cyclase). - Danio rerio
Length = 888
Score = 179 bits (436), Expect = 2e-43
Identities = 107/249 (42%), Positives = 144/249 (57%), Gaps = 16/249 (6%)
Query: 359 EFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-----KNTAKYSEN 413
+ E + RL F V A + ++ +R + +L NI+P HVA N YS++
Sbjct: 628 QLEYTARLDFLWRVQAKEEINEMRELREHNENMLRNILPSHVARHFLEKDRDNEELYSQS 687
Query: 414 HKDVAIIFASIINFNEMYDESYL--KGKEYLRILNELIADFDELLERPQFQHVEKIKTIG 471
+ V ++FASI F + Y ++ + +G E LR+LNE+IADFDELL +FQ +EKIKTIG
Sbjct: 688 YDTVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEERFQDIEKIKTIG 747
Query: 472 STFMAASGLNPDLRHASRGTYD-------HLYQLMDFALEMQKVVDNFNHDLFEFDFILR 524
ST+MA SGL R G + HL L DFA+ + + + N F +F LR
Sbjct: 748 STYMAVSGLLNVYRIWVIGMFKQCEDKWGHLCALADFAIALNESIQEINKHSFN-NFQLR 806
Query: 525 IGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFE 583
IG G V AGVIG K YDIWG VN+ASRMDSTGV +IQ+ E +L+ R + FE
Sbjct: 807 IGMAHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGKIQLPEETYAILNERGFAFE 866
Query: 584 PRGSVYVKG 592
RG +YVKG
Sbjct: 867 YRGEIYVKG 875
Score = 93.1 bits (221), Expect = 2e-17
Identities = 56/174 (32%), Positives = 92/174 (52%), Gaps = 13/174 (7%)
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
Y +++V+I+FA + F + + L +E +R+LNEL A FD L H +IK
Sbjct: 86 YIHRYENVSILFADVKGFTNL--STTLSAQELVRMLNELFARFDRLAHE---HHCLRIKI 140
Query: 470 IGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
+G + SGL P+ R DH + ++ L M K + + + D +RIG +
Sbjct: 141 LGDCYYCVSGL-PEPRP------DHAHCCVEMGLSMIKTI-RYVRSRTKHDIDMRIGIHS 192
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFE 583
G V GV+G K +D+W V+IA++++S G+P RI + +A + L+ YE E
Sbjct: 193 GSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKAALDCLNGDYEVE 246
>UniRef50_UPI000065D458 Cluster: Adenylate cyclase type 3 (EC 4.6.1.1)
(Adenylate cyclase type III) (ATP pyrophosphate-lyase 3)
(Adenylyl cyclase 3) (AC-III) (AC3) (Adenylate cyclase,
olfactive type).; n=1; Takifugu rubripes|Rep: Adenylate
cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III)
(ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III)
(AC3) (Adenylate cyclase, olfactive type). - Takifugu
rubripes
Length = 1159
Score = 177 bits (432), Expect = 5e-43
Identities = 110/281 (39%), Positives = 157/281 (55%), Gaps = 35/281 (12%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK-------- 409
R E+ R F + + K++V MR + L+ N++P HVA T
Sbjct: 860 RHLEVQSRKLFLWKIGVHDQKEKVFEMRRCNEALVTNMLPEHVAKHFLGTKMRDEVIFSV 919
Query: 410 -----YSENHKDVAIIFASIINFNEMYDESYLK--GKEYLRILNELIADFD--------- 453
Y +++ ++ ++FASI NF++ Y E + G E LRILNE+I+DFD
Sbjct: 920 YVRLHYHQSYNEIGVMFASIPNFSDFYTEESINNGGIECLRILNEIISDFDSVTFFCLFH 979
Query: 454 ELLERPQFQHVEKIKTIGSTFMAASGLNPDLR---------HASRGTYDHLYQLMDFALE 504
+LL+R +F+ + KIKTIGST+MAASGL P+ + + HL L DFAL
Sbjct: 980 QLLDREEFRSITKIKTIGSTYMAASGLTPECHTNGYDKPEDQSLFERWQHLSDLADFALS 1039
Query: 505 MQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQ 564
M+ ++N N F +F+LRIG N G V AGVIG K +YDIWG+ VN+ASRM+STGV
Sbjct: 1040 MKVTLNNLNKQSFN-NFMLRIGINKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMG 1098
Query: 565 RIQVGEACVPVL-SARYEFEPRGSVYVKGKDDMNVYLLVGK 604
IQV E C +L + F RG ++VKGK ++ + + GK
Sbjct: 1099 NIQVVEDCYNILKDYGFRFIRRGPIFVKGKGELLTFFMKGK 1139
Score = 72.5 bits (170), Expect = 3e-11
Identities = 49/177 (27%), Positives = 86/177 (48%), Gaps = 20/177 (11%)
Query: 418 AIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERP---QF-------QHVEKI 467
+I+FA I+ F ++ S +E +++LNEL A FD+L QF H +I
Sbjct: 333 SILFADIVGFTQL--SSACSAQELVKLLNELFARFDKLAAVSFCSQFLYFSFIKYHQLRI 390
Query: 468 KTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGY 527
K +G + GL PD R DH + L M + ++ + + + +R+G
Sbjct: 391 KILGDCYYCICGL-PDFRE------DHAACSIMMGLAMVDAI-SYVREKTKTEVDMRVGV 442
Query: 528 NFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP 584
+ G V GV+G + +D+W V +A++M+S G+P ++ + + L +E EP
Sbjct: 443 HTGTVLGGVLGQKRWQFDVWSTDVTVANKMESGGIPGKVHISQTTKDSLHGEFELEP 499
>UniRef50_Q5MAL2 Cluster: Adenylate cyclase; n=1; Aplysia
californica|Rep: Adenylate cyclase - Aplysia californica
(California sea hare)
Length = 1246
Score = 177 bits (430), Expect = 9e-43
Identities = 109/260 (41%), Positives = 153/260 (58%), Gaps = 12/260 (4%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHV-ADQLKNTAK----YS 411
+R+ E + RL + R+ ++V+ M +L NIIP HV A L+++ K Y
Sbjct: 984 DRQMEYANRLGHLFKMQFQRETEQVKMMAAINKIVLENIIPSHVIAYYLRSSRKHEDLYH 1043
Query: 412 ENHKDVAIIFASIINFNEMYDESYLKGK--EYLRILNELIADFDELLERPQFQHVEKIKT 469
E ++ V+++FASI NF + Y ++ G+ E +R+LNE+I+DFD LL +FQ VEKIKT
Sbjct: 1044 EAYESVSVMFASIPNFKDFYQQTKSNGEGMECIRVLNEIISDFD-LLVIKKFQDVEKIKT 1102
Query: 470 IGSTFMAASGLNPDL--RHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGY 527
IGST+MAA+GL+ + +++F+L M +D N F +F LRIG
Sbjct: 1103 IGSTYMAATGLHRGQAGNQDDEAGERTIVTMVEFSLAMMSTLDTVNQHSFN-NFSLRIGV 1161
Query: 528 NFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-SARYEFEPRG 586
N G V AGVIG K YDIWGD VN+ASRMDS+G P +IQ+ E VL Y E RG
Sbjct: 1162 NHGPVIAGVIGARKPQYDIWGDTVNVASRMDSSGEPGKIQMREETAAVLVKYGYNLELRG 1221
Query: 587 SVYVKGKDDMNVYLLVGKKD 606
VKGK+ M + L+ KK+
Sbjct: 1222 ITKVKGKEPMKTFYLLHKKE 1241
Score = 89.0 bits (211), Expect = 3e-16
Identities = 62/216 (28%), Positives = 100/216 (46%), Gaps = 29/216 (13%)
Query: 370 SNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHKDVAIIFASIINFNE 429
SN+V K +NMR L H++ Y + + V+I++A I+NF
Sbjct: 424 SNLVKEIKKDLQENMREPRPTLFHDL--------------YVQRYHGVSILYADIVNFTP 469
Query: 430 MYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL-NPDLRHAS 488
+ E E +++LNEL FD+L ++ +IK +G + SG+ D +HA
Sbjct: 470 LASEC--TAAELVKMLNELFGRFDQLAKKSSCM---RIKILGDCYYCVSGIPTADKKHA- 523
Query: 489 RGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWG 548
+ + L M + + + D +RIG + G V GV+G K YD+W
Sbjct: 524 -------HNCVRMGLRMLDAIRDVRENT-GVDVDMRIGVHTGSVLCGVLGLRKWQYDVWS 575
Query: 549 DAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP 584
D V IA+ M+S GVP R+ + + + L Y+ EP
Sbjct: 576 DDVTIANNMESGGVPGRVHISKQTLDCLDGEYDVEP 611
>UniRef50_Q0C7B2 Cluster: Adenylate cyclase; n=2; Culicidae|Rep:
Adenylate cyclase - Aedes aegypti (Yellowfever mosquito)
Length = 1400
Score = 176 bits (428), Expect = 2e-42
Identities = 100/252 (39%), Positives = 148/252 (58%), Gaps = 7/252 (2%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK----YSEN 413
R E++ RL F A ++ +++ R+ D L+ NI+P HVA + + Y++
Sbjct: 1007 RLVEVTSRLDFIWKEQAEKELSNMKSNRHLNDLLIKNILPDHVASYYLSEERADELYAQM 1066
Query: 414 HKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGST 473
H+ ++FASI NF + Y E GK +RILNE+I+DFD LLE +F+ VEKIKT+G+T
Sbjct: 1067 HELCGVMFASIPNFKDFYSEDIENGKACIRILNEIISDFDSLLEEERFKTVEKIKTVGAT 1126
Query: 474 FMAASGL-NPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDV 532
+MAAS L + + + + L++FAL M++ + N D F F LR+G + G +
Sbjct: 1127 YMAASNLRSGNKTKVDEKDEEAVCDLVEFALAMRQKLQEVNKDAFN-TFQLRVGISSGPL 1185
Query: 533 TAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSVYVK 591
+GVIG K YDIWG+ VN+ASRMDSTG ++QV + +L + Y RG V VK
Sbjct: 1186 VSGVIGARKPVYDIWGNTVNVASRMDSTGENWKVQVPDYTAALLQTKGYTCVQRGEVNVK 1245
Query: 592 GKDDMNVYLLVG 603
GK M Y ++G
Sbjct: 1246 GKGLMLTYWVLG 1257
Score = 87.8 bits (208), Expect = 7e-16
Identities = 54/172 (31%), Positives = 90/172 (52%), Gaps = 10/172 (5%)
Query: 414 HKD-VAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGS 472
H D V+I+FA I F E+ ++ ++ +++LN+L A FD++ E H +IK +G
Sbjct: 364 HMDNVSILFADIKGFTELASKT--SAQQLVKVLNDLFARFDKIAED---NHCLRIKLLGD 418
Query: 473 TFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDV 532
+ S + + + DH ++ L M K + + D +RIG + G V
Sbjct: 419 CYYCVSMFDSQ---SWKSRPDHAVCSVETGLHMIKAIKDVRVQT-NVDLDMRIGIHSGSV 474
Query: 533 TAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP 584
GV+G K ++D+W + V IA+ M+S GVP R+ + EA + L+ YE EP
Sbjct: 475 MCGVLGEKKWHFDVWSNDVIIANHMESGGVPGRVHISEATLNCLNDTYEVEP 526
>UniRef50_A7S0C5 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella vectensis
Length = 1212
Score = 174 bits (424), Expect = 5e-42
Identities = 94/210 (44%), Positives = 132/210 (62%), Gaps = 6/210 (2%)
Query: 401 ADQLKNTAKYSENHKDVAIIFASIINFNEMYDESYLK--GKEYLRILNELIADFDELLER 458
AD+ K YS ++K V+++FASI NF+E Y E + G E +R+LNE+I DFDE+L
Sbjct: 881 ADEKKKEDLYSHSYKRVSVMFASIPNFSEFYSEDNINNGGVECIRLLNEVITDFDEVLAD 940
Query: 459 PQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFE 518
P+F VEKIKTI ST+MAASGL P+ A +L ++DFAL ++ +D N + F
Sbjct: 941 PRFLGVEKIKTISSTYMAASGLRPESEDAEES--QNLVDIVDFALTLRDKLDFINQESFN 998
Query: 519 FDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQV-GEACVPVLS 577
F+LR+G G + AGVIG K +YDIWG+ VN+ASRM++TG IQ+ + +
Sbjct: 999 -QFVLRVGICQGPIVAGVIGAKKPHYDIWGNTVNVASRMETTGKAGCIQITAQTYETIKD 1057
Query: 578 ARYEFEPRGSVYVKGKDDMNVYLLVGKKDT 607
+ F RG+V VKGK + Y L G+K+T
Sbjct: 1058 KDFVFVYRGAVRVKGKGQLITYYLTGRKNT 1087
Score = 78.6 bits (185), Expect = 4e-13
Identities = 55/208 (26%), Positives = 100/208 (48%), Gaps = 28/208 (13%)
Query: 391 LLHNIIPRHVADQLK-------------NTAK--YSENHKDVAIIFASIINFNEMYDESY 435
LL +++P+HVA+++ N K + H +I+FA I+ F E+ S
Sbjct: 322 LLLSVLPKHVAEEMTKDFEGDGNPALTDNAFKKLFIRTHDTCSILFADIVGFTEL--SSK 379
Query: 436 LKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHL 495
++ + LNEL A+FD+L + H +IK +G + SGL+ HA
Sbjct: 380 CTAEQLIVTLNELFANFDKLAAK---NHCLRIKILGDCYYCISGLDDSCNHALCA----- 431
Query: 496 YQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIAS 555
++ L+M + + + + +R+G + G V AGV+G K ++ W + V +A+
Sbjct: 432 ---VNMGLDMVEHIAHVREEKGVKSLNMRVGIHTGMVLAGVLGQRKWQFEAWSNDVTLAN 488
Query: 556 RMDSTGVPQRIQVGEACVPVLSARYEFE 583
M+S G+P R+ + E + + +E E
Sbjct: 489 HMESGGIPGRVHISEPTLNSIKDYFEVE 516
>UniRef50_UPI000155DD86 Cluster: PREDICTED: similar to adenylate
cyclase 7; n=1; Equus caballus|Rep: PREDICTED: similar
to adenylate cyclase 7 - Equus caballus
Length = 958
Score = 170 bits (414), Expect = 8e-41
Identities = 98/237 (41%), Positives = 143/237 (60%), Gaps = 13/237 (5%)
Query: 376 RDKQRVQNMRNQADWLLHNIIPRHVA-----DQLKNTAKYSENHKDVAIIFASIINFNEM 430
++ + + M N LL N++P HVA D+L N Y +++ V ++FAS+ +F
Sbjct: 711 KEHEEFETMENVNRLLLENVLPAHVAAHFIGDKL-NEDWYHQSYDCVCVMFASVPDFKVF 769
Query: 431 YDESYL--KGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHAS 488
Y E + +G E LR+LNE++ADFDELL +P+F VEKIKTIGST+MAA+GL+ H +
Sbjct: 770 YTECDVNKEGLECLRLLNEIVADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVPSGHDN 829
Query: 489 RG---TYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYD 545
+ + H+ +++F++ + +D N F F LR+G N G V AGVIG K YD
Sbjct: 830 QDLERQHAHIGIMVEFSIALMSKLDGINRHSFN-SFRLRVGINHGPVIAGVIGARKPQYD 888
Query: 546 IWGDAVNIASRMDSTGVPQRIQVGEACVPVLSA-RYEFEPRGSVYVKGKDDMNVYLL 601
IWG+ VN+ASRM+STG +IQV E +L Y E RG + VKGK ++ Y +
Sbjct: 889 IWGNTVNVASRMESTGELGKIQVTEETSAILQGLGYSCECRGLINVKGKGELRTYFV 945
Score = 80.6 bits (190), Expect = 1e-13
Identities = 49/166 (29%), Positives = 83/166 (50%), Gaps = 13/166 (7%)
Query: 418 AIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAA 477
+I++A I+ F ++ + KE + +LNEL FD++ + + +IK +G +
Sbjct: 151 SILYADIVGFTQLASDC--SPKELVVVLNELFGKFDQIAKANECM---RIKILGDCYYCV 205
Query: 478 SGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVI 537
SGL L H + L+M + + + D +R+G + G+V GVI
Sbjct: 206 SGLPVSLP-------THARNCVKMGLDMCEAIKQVR-EATGVDISMRVGIHSGNVLCGVI 257
Query: 538 GTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFE 583
G K YD+W V++A+RM++ GVP R+ + EA + L YE E
Sbjct: 258 GLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLNHLDKAYEVE 303
>UniRef50_Q8MZE0 Cluster: AT09365p; n=1; Drosophila
melanogaster|Rep: AT09365p - Drosophila melanogaster
(Fruit fly)
Length = 532
Score = 169 bits (411), Expect = 2e-40
Identities = 95/218 (43%), Positives = 134/218 (61%), Gaps = 10/218 (4%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK-----YS 411
+ + E +YRL F + A +K+ +++++ LL NI+P HVA+ + K Y
Sbjct: 55 SHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYH 114
Query: 412 ENHKDVAIIFASIINFNEMYDE--SYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
E V I+FASI NF+E Y E +G E LR+LNE+IADFDELL +F+ +EKIK+
Sbjct: 115 EQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKS 174
Query: 470 IGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
G+T+MAASGL + R + H+ + D+AL++ ++ N F +F +RIG N
Sbjct: 175 TGATYMAASGLTANT--CDRVNFSHVTAMADYALQLFDKIEEVNMHSFN-NFRMRIGINI 231
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQ 567
G V AGVIG K YDIWG+AVN+ASRMDSTG+ IQ
Sbjct: 232 GPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQ 269
>UniRef50_Q966F9 Cluster: Adenylyl cyclase protein 4; n=2;
Caenorhabditis|Rep: Adenylyl cyclase protein 4 -
Caenorhabditis elegans
Length = 954
Score = 160 bits (388), Expect = 1e-37
Identities = 102/261 (39%), Positives = 147/261 (56%), Gaps = 17/261 (6%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK-----YSE 412
R E+ R F + A ++ +++ Q +L NI+P HVA A Y E
Sbjct: 692 RRSELISRYDFIWKLQALDEQLQMKRKHEQNRSVLENILPSHVAKHFVEDATSVSKLYHE 751
Query: 413 NHKDVAIIFASIINFNEMYDE--SYLKGKEYLRILNELIADFDELLE----RPQFQHVEK 466
+ + I+FA++ F++ Y E +G E LR+LNE+I+DFD++L+ R +F+ +EK
Sbjct: 752 SRDNACIMFATLTEFDKFYIECDGNNEGVECLRLLNEIISDFDQILDQILDREEFKKIEK 811
Query: 467 IKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIG 526
IKTI +T+M ASGL G H+ + FA E+ +++ N F +F LRIG
Sbjct: 812 IKTISTTYMVASGL----AGRECGDNSHVEAIALFARELLVKLESTNIHSFN-NFNLRIG 866
Query: 527 YNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLS-ARYEFEPR 585
N G V AGVIG+ K +YDIWG++VN+ASRMDS GV RIQV E +L Y FE R
Sbjct: 867 INVGPVVAGVIGSDKPHYDIWGNSVNVASRMDSGGVAGRIQVTEEVKSILEPLGYNFECR 926
Query: 586 GSVYVKGKDDMNVYLLVGKKD 606
G + VKGK M + L+ +D
Sbjct: 927 GQINVKGKGMMETFFLLPPED 947
Score = 66.9 bits (156), Expect = 1e-09
Identities = 50/234 (21%), Positives = 108/234 (46%), Gaps = 24/234 (10%)
Query: 361 EISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK----------- 409
E R +F+ + + + ++ + +L ++P+++A ++K +
Sbjct: 175 EFVQRKTFHETRKCVQSRMLLDKEMHRQEKILLAVLPKNIAFEVKKDMQETHEERMFHKI 234
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
Y ++D++I+FA I F + E K+ + +LNEL A FD++ Q +IK
Sbjct: 235 YIRKYEDISILFADICGFTNLASE--YNPKDLVLMLNELFARFDKVASIHQCM---RIKI 289
Query: 470 IGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
+G + G+ P+ + +H ++ +M + + ++ + +R+G +
Sbjct: 290 LGDCYYCVCGV-PEYQK------NHAINTVEMGRDMIEAI-RLVREMTLVNVNMRVGIHT 341
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFE 583
G GV+G K +D+W + V +A++M+S G+ R+ + +A L Y E
Sbjct: 342 GKAHCGVLGLKKWQFDVWSNDVTLANQMESGGLAGRVHITDATRSYLKGAYILE 395
>UniRef50_O16880 Cluster: Adenylyl cyclase protein 2; n=2;
Caenorhabditis|Rep: Adenylyl cyclase protein 2 -
Caenorhabditis elegans
Length = 1080
Score = 155 bits (377), Expect = 2e-36
Identities = 96/258 (37%), Positives = 150/258 (58%), Gaps = 28/258 (10%)
Query: 371 NVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK-----YSENHKDVAIIFASII 425
+V +++ V+ M++ L+ NI+P VA + + + Y+ H++V ++FASI
Sbjct: 797 HVSFQNEERDVETMQDINKILIENILPSSVAAKFLSPDRAVNELYARQHENVCVMFASIP 856
Query: 426 NFNEMYDESYLKGK-EYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPD- 483
NF + + E K E LR+LNE++ +FD+LL +P+F VEKIKT+GST+MAA+GLN
Sbjct: 857 NFKDFWSEWDTNRKLECLRLLNEIVCEFDKLLSKPKFSSVEKIKTVGSTYMAAAGLNESE 916
Query: 484 -------LRHASRGTYDHLYQ-----------LMDFALEMQKVVDNFNHDLFEFDFILRI 525
L + G Y++ + +++FAL M +++D N D F+ +F LRI
Sbjct: 917 ADYDDIYLEKQNSGKYNNNIRHGNMAFRNANLMIEFALAMSQILDALNRDSFQ-NFELRI 975
Query: 526 GYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-SARYEFEP 584
G + G + AGVIG K YDIWG+ VN+ASRMD+ G P++I VL + Y +
Sbjct: 976 GMSVGPLVAGVIGAQKPQYDIWGNTVNLASRMDTHGEPRKIHATTDMGRVLQTGGYRVQS 1035
Query: 585 RGSVYVKG-KDDMNVYLL 601
RG + VKG K+ M +L+
Sbjct: 1036 RGKIRVKGVKEPMETFLI 1053
Score = 75.4 bits (177), Expect = 4e-12
Identities = 52/167 (31%), Positives = 82/167 (49%), Gaps = 13/167 (7%)
Query: 414 HKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGST 473
H +V+I+FA I+NF + + L K+ +R LNEL + FD +R Q +IK +G
Sbjct: 310 HDNVSILFADIVNFTVL--AAQLTAKDLVRTLNELYSKFDRDAQRLQCM---RIKFLGDC 364
Query: 474 FMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVT 533
+ SG+ P R +H + LEM + D +RIG + G V
Sbjct: 365 YYCVSGM-PVNRP------NHADMCVVMGLEMINTIKQVRIAT-GVDVNMRIGVHTGSVL 416
Query: 534 AGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARY 580
G++G K +DIW D V +A+ M+S GVP + + ++ +L Y
Sbjct: 417 CGIMGLRKWQFDIWSDDVTLANHMESAGVPGAVHITKSTKDMLLGDY 463
>UniRef50_A0YQ82 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC
8106|Rep: Adenylate cyclase - Lyngbya sp. PCC 8106
Length = 442
Score = 154 bits (374), Expect = 6e-36
Identities = 91/243 (37%), Positives = 135/243 (55%), Gaps = 15/243 (6%)
Query: 365 RLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKN--TAKYSENHKDVAIIFA 422
R F S + Q++Q + +++ L+ NI+P +A +LK ++N D ++F
Sbjct: 212 RSEFNSRLALEEAYQQLQVEQERSEALILNILPVPIAQRLKQKPVTTIADNFTDAGVLFG 271
Query: 423 SIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNP 482
I+ F E+ + + E +++L ++ + FD L ++ ++EKIKTIG +M SGL P
Sbjct: 272 DIVGFTELSGK--MPPAELVQLLGQIFSRFDHLADK---HNLEKIKTIGDAYMVVSGL-P 325
Query: 483 DLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKL 542
+ D+ ++ D AL+MQK + FN + E F +RIG G V AGVIG K
Sbjct: 326 IPKE------DYAERIADMALDMQKTILEFNAET-ERKFQMRIGIAIGPVVAGVIGLRKF 378
Query: 543 YYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLLV 602
YD+WGD VNIASRM+S G+ IQV E L Y E RG++ VKGK +M YLL
Sbjct: 379 IYDLWGDTVNIASRMESHGIANEIQVTETTYHALKDDYSLEKRGTILVKGKGEMTTYLLK 438
Query: 603 GKK 605
GKK
Sbjct: 439 GKK 441
>UniRef50_UPI0000DB7252 Cluster: PREDICTED: similar to ACXD CG5712-PA;
n=1; Apis mellifera|Rep: PREDICTED: similar to ACXD
CG5712-PA - Apis mellifera
Length = 1051
Score = 154 bits (373), Expect = 7e-36
Identities = 100/261 (38%), Positives = 143/261 (54%), Gaps = 23/261 (8%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK------Y 410
+R+ E RL + +++ + RN +LL NI+P HVA+ N + Y
Sbjct: 779 DRQAEYLNRLDYLWKRQLTKEQDEAFHTRNANKFLLRNILPEHVAEFYLNMNRTVENEPY 838
Query: 411 SENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
E H +VA++FAS+ + + DES L +LNE+I +FD+LL P F +EKIK
Sbjct: 839 HEAHSNVAVMFASLTDVS--IDES-----NTLAVLNEIICEFDKLLFEPYFNRIEKIKIA 891
Query: 471 GSTFMAASGLNPDLRHASRGTY------DHLYQLM-DFALEMQKVVDNFNHDLFEFD--F 521
G+T+MAA GL R + R D++ ++M FA+EM V+D F +
Sbjct: 892 GTTYMAACGLEASRRDSMRSPENEENITDNVVKVMAQFAVEMIAVLDKLKMRTFYTSKPY 951
Query: 522 ILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-Y 580
LRIG + G+VTAGV+G K YDIWGDAVN+ASRMD+TGVP +IQ+ VL +
Sbjct: 952 RLRIGISHGEVTAGVVGAQKPLYDIWGDAVNMASRMDTTGVPGKIQITAETAAVLEQQGI 1011
Query: 581 EFEPRGSVYVKGKDDMNVYLL 601
+ RG YVK K + Y +
Sbjct: 1012 KCHLRGDTYVKPKGLVTTYFI 1032
Score = 83.8 bits (198), Expect = 1e-14
Identities = 66/254 (25%), Positives = 125/254 (49%), Gaps = 39/254 (15%)
Query: 361 EISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLK----NTAKYSENHK- 415
EI R SF + R+ ++Q + L +I+P+H+A ++K + K+ E HK
Sbjct: 155 EIVTRRSFLDHRKCVESTLRLNYEKDQEEQLTRSILPQHIAAKIKKEFRDIFKFLEEHKK 214
Query: 416 ----------------DVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERP 459
+V+I++A ++NF+ + L ++ + LN+L FDE ER
Sbjct: 215 PPKPSSFSDLCVETHNNVSILYADVVNFSGL--TVTLPVRKLVETLNDLFGSFDEASER- 271
Query: 460 QFQHVEKIKTIGSTFMAASGL-NPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFE 518
+V +IK +G + SG+ P+ +HA +D L+M K++ + +
Sbjct: 272 --HNVLRIKFLGDCYYCVSGVPTPNSQHAK--------SCVDLGLDMIKIIKDVRAKVRR 321
Query: 519 ---FDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPV 575
D +RIG + G++ +G++G +K YD+W V IA++M+ TG P ++ + + + +
Sbjct: 322 ESGVDVNMRIGVHSGNIISGILGVSKWQYDVWSRDVVIANKMEQTGKPGKVHITQQTLDL 381
Query: 576 LSA-RYEFEPRGSV 588
+ A Y+ P S+
Sbjct: 382 VDANEYDCVPVDSL 395
>UniRef50_Q10XK8 Cluster: Adenylate/guanylate cyclase precursor; n=1;
Trichodesmium erythraeum IMS101|Rep: Adenylate/guanylate
cyclase precursor - Trichodesmium erythraeum (strain
IMS101)
Length = 1209
Score = 152 bits (368), Expect = 3e-35
Identities = 87/222 (39%), Positives = 129/222 (58%), Gaps = 14/222 (6%)
Query: 385 RNQADWLLHNIIPRHVADQLK-NTAKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLR 443
+ +++ LL NI+P+ +AD+LK N +E +V ++FA ++ F ++ Y K Y
Sbjct: 998 QGKSEKLLLNILPKPIADKLKENQDIIAEGFDEVTVLFADLVGFTQLASSVYPKRLVYW- 1056
Query: 444 ILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFAL 503
LNE+ + FD L E+ +EKIKTIG +M GL + + H + A+
Sbjct: 1057 -LNEIFSKFDLLAEK---YGLEKIKTIGDAYMVVGGLPTPMEN-------HAEAIALIAI 1105
Query: 504 EMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVP 563
+M++ + +F H + DF++RIG N G V AGVIG K YD+WGD VNIASRM+S G+P
Sbjct: 1106 DMREELAHFAHKSKQ-DFLIRIGINTGPVVAGVIGRKKFIYDLWGDTVNIASRMESQGIP 1164
Query: 564 QRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLLVGKK 605
IQV EA +L ++ F RG +++KGK M Y L GKK
Sbjct: 1165 GVIQVTEATYQILKHKFLFTERGLIHIKGKGYMKTYFLQGKK 1206
>UniRef50_A0YU66 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC
8106|Rep: Adenylate cyclase - Lyngbya sp. PCC 8106
Length = 833
Score = 151 bits (367), Expect = 4e-35
Identities = 91/223 (40%), Positives = 132/223 (59%), Gaps = 15/223 (6%)
Query: 385 RNQADWLLHNIIPRHVADQLKNTAK--YSENHKDVAIIFASIINFNEMYDESYLKGKEYL 442
R +++ LL NI+P+ + + LK + +E + +V+I+FA +++F + + L + +
Sbjct: 624 REKSERLLLNILPQKIVETLKQEKQGLIAEKYDEVSILFADLVDFTALSER--LTPIQLV 681
Query: 443 RILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFA 502
++LNE+ + FD+L E +EKIKTIG +M A+GL P R DH + D A
Sbjct: 682 KLLNEIFSTFDQLAEGLD---LEKIKTIGDAYMMAAGL-PLPRE------DHAETIADMA 731
Query: 503 LEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGV 562
L MQ VVD+F D E +RIG + G V AGVIGT K YD+WGD VNIA RM+S+G
Sbjct: 732 LSMQLVVDHFPFDYGE-TLQIRIGIHTGTVVAGVIGTHKFIYDLWGDTVNIAYRMESSGK 790
Query: 563 PQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLLVGKK 605
P +IQV A L Y FE RG + +KGK M Y L+G++
Sbjct: 791 PGKIQVTAAVYERLKNEYIFEKRGEIPIKGKGKMMTYWLIGRQ 833
>UniRef50_Q1H0Z8 Cluster: Adenylate/guanylate cyclase; n=1;
Methylobacillus flagellatus KT|Rep: Adenylate/guanylate
cyclase - Methylobacillus flagellatus (strain KT / ATCC
51484 / DSM 6875)
Length = 426
Score = 151 bits (365), Expect = 7e-35
Identities = 88/224 (39%), Positives = 132/224 (58%), Gaps = 15/224 (6%)
Query: 385 RNQADWLLHNIIPRHVADQLKNT--AKYSENHKDVAIIFASIINFNEMYDESYLKGKEYL 442
+++++ LL +I+P VA +L T + +++H V I+FA I+NF ++ + + +
Sbjct: 208 KSRSEQLLRSILPESVAKRLHETQCGRIADSHDAVTILFADIVNFTQI--SAGMTPAAVV 265
Query: 443 RILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFA 502
+LN + + FD+L + VEKIKTIG +M +G P R DH + + D A
Sbjct: 266 DLLNHVFSRFDQLAAQ---YGVEKIKTIGDAYMVIAGA-PSPRT------DHAHVMADMA 315
Query: 503 LEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGV 562
LE+ ++D + ++ +RIG N G V AG+IG T+ YD+WGDAVNIASRM++TG+
Sbjct: 316 LEVPALLDKVSREI-GMPLAMRIGMNSGAVVAGIIGNTRFSYDLWGDAVNIASRMETTGL 374
Query: 563 PQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLLVGKKD 606
P IQV A +L A Y FEPR V VKGK + YLL G+ D
Sbjct: 375 PNEIQVSAATYELLKADYCFEPRCGVDVKGKGKVVTYLLKGRMD 418
>UniRef50_A0YN57 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC
8106|Rep: Adenylate cyclase - Lyngbya sp. PCC 8106
Length = 545
Score = 151 bits (365), Expect = 7e-35
Identities = 87/220 (39%), Positives = 130/220 (59%), Gaps = 14/220 (6%)
Query: 385 RNQADWLLHNIIPRHVADQLKNTAK-YSENHKDVAIIFASIINFNEMYDESYLKGKEYLR 443
+ +++ LL NI+P +A +LKN + ++N ++V ++FA I F ++ + + E +
Sbjct: 337 QEKSERLLLNILPESIALRLKNKPETIADNFEEVTVLFADIAGFTQL--SAKISPTELVN 394
Query: 444 ILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFAL 503
+LNE+ ++FD++ + ++EKIKTIG ++ GL P+ R DH + AL
Sbjct: 395 LLNEIFSEFDQITTQ---NNLEKIKTIGDAYLVVGGL-PNPRS------DHAEAIAKLAL 444
Query: 504 EMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVP 563
EMQ + FN + + LRIG N G V AGVIG K YD+WGD VNIASRM+S G+
Sbjct: 445 EMQNKLIEFNQK-HDHNLQLRIGINTGPVVAGVIGAKKFIYDLWGDTVNIASRMESHGII 503
Query: 564 QRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLLVG 603
IQV EA L +Y+FE RG + VKGK +M+ Y L G
Sbjct: 504 GEIQVTEATYQRLQDKYKFEKRGLINVKGKGEMSTYFLKG 543
>UniRef50_A0YS29 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC
8106|Rep: Adenylate cyclase - Lyngbya sp. PCC 8106
Length = 657
Score = 150 bits (363), Expect = 1e-34
Identities = 87/225 (38%), Positives = 130/225 (57%), Gaps = 14/225 (6%)
Query: 378 KQRVQNMRNQADWLLHNIIPRHVADQL-KNTAKYSENHKDVAIIFASIINFNEMYDESYL 436
+Q +Q+ + Q + LL NI+P+ +A++L K ++ +DV+++FA ++ F + E+
Sbjct: 442 QQELQSQKEQTEKLLLNILPQPIAERLQKQPGIIADYFQDVSVLFADLVGFTDFSSEA-- 499
Query: 437 KGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLY 496
+ L ILN + + FD+L Q +EKIKTIG +M GL L H DHL+
Sbjct: 500 TPAQILEILNSIFSHFDQL---SQHYGLEKIKTIGDAYMVVGGL--PLYHR-----DHLH 549
Query: 497 QLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASR 556
+ AL+MQ + FN +F+LRIG + G V AGVIG +K YD+WGD VN+ASR
Sbjct: 550 AIAKMALDMQTNLTQFNQQTGN-NFLLRIGIHAGPVVAGVIGLSKFSYDLWGDTVNVASR 608
Query: 557 MDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLL 601
M+S GV +IQV L ++ F RGS+ +KGK +M Y L
Sbjct: 609 MESNGVSGQIQVTSEVYERLKDQFVFALRGSIPIKGKGEMTTYFL 653
>UniRef50_Q9EXQ2 Cluster: Adenylate cyclase; n=3;
Oscillatoriales|Rep: Adenylate cyclase - Spirulina
platensis
Length = 671
Score = 147 bits (357), Expect = 6e-34
Identities = 91/225 (40%), Positives = 128/225 (56%), Gaps = 17/225 (7%)
Query: 385 RNQADWLLHNIIPRHVADQLK-NTAKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLR 443
+ +++ LL N++P+ +ADQLK N + ++V I+FA I+ F + + + E +
Sbjct: 454 KERSEELLLNVLPKPIADQLKANKKAIASAIEEVTILFADIVGFTPL--SARMDPIELVS 511
Query: 444 ILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLN-PDLRHASRGTYDHLYQLMDFA 502
+LNE+ + FD L ++ + +EKIKTIG +M GL P HA + D A
Sbjct: 512 LLNEMFSIFDNLADKHK---LEKIKTIGDAYMVVGGLPLPQNNHAEA--------IADMA 560
Query: 503 LEMQKVVDNF--NHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDST 560
LEMQ + F ++ + F +RIG N G V AGVIG K YD+WGDAVNIASRM+S+
Sbjct: 561 LEMQAAMKQFQGSYLMGSESFQIRIGINTGAVVAGVIGIKKFIYDLWGDAVNIASRMESS 620
Query: 561 GVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLLVGKK 605
G P IQV E L Y F+ RG + VKGK M Y L+GKK
Sbjct: 621 GTPGSIQVTEETYHRLKYNYIFKKRGLIPVKGKGQMTTYWLLGKK 665
>UniRef50_A0YPF4 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC
8106|Rep: Adenylate cyclase - Lyngbya sp. PCC 8106
Length = 491
Score = 146 bits (353), Expect = 2e-33
Identities = 90/246 (36%), Positives = 136/246 (55%), Gaps = 15/246 (6%)
Query: 361 EISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKN-TAKYSENHKDVAI 419
E+ R+ F R + N + +++ LL +I+P+ +A++LKN ++ + I
Sbjct: 252 ELEQRV-FERTTELRRANIELSNEQKKSEELLLSILPQSIANRLKNGEVNIADCFAEATI 310
Query: 420 IFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASG 479
+FA I+ F + E +K ++ +RILNE+ +DFD L +R + +EKIKTIG +M G
Sbjct: 311 LFADIVGFTTLSKE--VKPEKVVRILNEIFSDFDRLCDRYK---LEKIKTIGDAYMVVGG 365
Query: 480 LNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGT 539
L P+ R DH + + AL+M ++ FN +RIG N G V AG+IGT
Sbjct: 366 L-PNPRK------DHAAAIAEMALDMLDDLNQFNAKN-NVKLEIRIGINSGPVIAGIIGT 417
Query: 540 TKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVY 599
K YD+WGDAVN ASRM+S G+ IQ+ E L + F RG + +KGK M Y
Sbjct: 418 KKFIYDLWGDAVNTASRMESHGIAGEIQLTETTFDYLQKEFLFVERGLIEIKGKGKMRTY 477
Query: 600 LLVGKK 605
LL G++
Sbjct: 478 LLKGRR 483
>UniRef50_Q4SU92 Cluster: Chromosome 3 SCAF13974, whole genome shotgun
sequence; n=1; Tetraodon nigroviridis|Rep: Chromosome 3
SCAF13974, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 1108
Score = 145 bits (352), Expect = 3e-33
Identities = 104/287 (36%), Positives = 151/287 (52%), Gaps = 54/287 (18%)
Query: 359 EFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVA------DQLKNTAK--- 409
+ E RL F + A ++ + ++ +R + LL NI+P HVA D+ A+
Sbjct: 756 QLEAMARLDFLWRLQARKEVEDMRELREHNECLLLNILPAHVAQHFLERDRSNEVARLRL 815
Query: 410 ----------------YSENHKDVAIIFASIINFNEMYDESYLKGKEY--LRILNELIAD 451
YS++++ V ++FAS+ F+ Y++ + + LR+LN +I D
Sbjct: 816 SACTCAGVNLAFAQELYSQSYQRVGVLFASLPGFSRYYEQKEAADRHFECLRLLNHIITD 875
Query: 452 FDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHAS--RGTYDHLYQLMDFALEMQKVV 509
FDELL+ FQ VEKIKT+GS++MAASGL+PD + + HL +L+ FAL MQ+ +
Sbjct: 876 FDELLDESYFQDVEKIKTMGSSYMAASGLSPDRQSVQECEDAWHHLGELVLFALSMQETL 935
Query: 510 DNFNHDLFEFDFILRIGYN-----------------------FGDVTAGVIGTTKLYYDI 546
+ N D F LR+G N G V AGVIG TK YDI
Sbjct: 936 SHINTDTGN-SFQLRVGDNNKKKRELMKALDSPPLATSTGVAHGPVIAGVIGATKPQYDI 994
Query: 547 WGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSVYVKG 592
WG VN+ASRM+STG+ IQV EA +L R + + RGS+Y+KG
Sbjct: 995 WGTTVNLASRMESTGISGMIQVPEATSCILVERGFLRQLRGSIYIKG 1041
Score = 57.6 bits (133), Expect = 9e-07
Identities = 49/173 (28%), Positives = 77/173 (44%), Gaps = 22/173 (12%)
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLE------------ 457
Y ++KDV+I+FA II F + L +E +R LNEL FD L E
Sbjct: 271 YIHHYKDVSILFADIIGFTSL--SLILSAQELVRTLNELFGRFDRLAEVSVLSGASLFAY 328
Query: 458 ----RPQFQHVEKIKTIGSTFMAASGLNP--DLRHASRGTYDHLY-QLMDFALEMQKVVD 510
R V +T T G P D H + T+ H + + + ++
Sbjct: 329 QDPGRLLLLRVWGPRTSEGTRPQLRGHGPQHDQHHTVKVTHTHTHTEERRSGSNVWRLCS 388
Query: 511 NFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVP 563
++ + + +RIG + G V GV+G K +DIW V+IA+ +++ GVP
Sbjct: 389 YVRREI-QLELDMRIGVHSGSVLCGVLGLQKWQFDIWSWDVDIANSLEAAGVP 440
>UniRef50_A0YSC8 Cluster: Extracellular ligand-binding receptor; n=3;
Bacteria|Rep: Extracellular ligand-binding receptor -
Lyngbya sp. PCC 8106
Length = 1301
Score = 144 bits (350), Expect = 5e-33
Identities = 91/231 (39%), Positives = 130/231 (56%), Gaps = 18/231 (7%)
Query: 377 DKQRVQNMRNQADWLLHNIIPRHVADQLKNTA-KYSENHKDVAIIFASIINFNEMYDESY 435
D R++ +++ LL NI+PR +A++LK +E I+FA I++F S
Sbjct: 1087 DALRIEQQKSER--LLQNILPRSIAERLKQAPHSIAERFDHATIMFADIVDFTGF--SSQ 1142
Query: 436 LKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHL 495
+ E + +LNE+ + FD ++ +EKIKTIG ++M GL P + DH+
Sbjct: 1143 IAPTELVDLLNEIFSAFDAFAQK---HDLEKIKTIGDSYMVVGGL-PTPKD------DHV 1192
Query: 496 YQLMDFALEMQKVVDNFN-HDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIA 554
+ + AL+MQ+ + F HD F LRIG N G V AGVIGT K YD+WGDAVN+A
Sbjct: 1193 KAIAEMALDMQREICRFQRHD--GLPFRLRIGINTGPVVAGVIGTRKFIYDLWGDAVNVA 1250
Query: 555 SRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLLVGKK 605
SRM+S G +IQV +A +L +Y FE RG + VKG M Y L G+K
Sbjct: 1251 SRMESHGEAGKIQVTKATYDLLKDQYIFEKRGIIDVKGIGRMATYWLQGRK 1301
>UniRef50_UPI000038D385 Cluster: COG2114: Adenylate cyclase, family
3 (some proteins contain HAMP domain); n=1; Nostoc
punctiforme PCC 73102|Rep: COG2114: Adenylate cyclase,
family 3 (some proteins contain HAMP domain) - Nostoc
punctiforme PCC 73102
Length = 433
Score = 143 bits (347), Expect = 1e-32
Identities = 84/225 (37%), Positives = 128/225 (56%), Gaps = 14/225 (6%)
Query: 378 KQRVQNMRNQADWLLHNIIPRHVADQLKNT-AKYSENHKDVAIIFASIINFNEMYDESYL 436
++ ++ + +++ LL NI+P +A+QLK +++ +V ++FA I+ F E+ +
Sbjct: 215 RKAMELAQQKSERLLLNILPGMIAEQLKQQPTTIADSFMEVTVLFADIVGFTEL--SART 272
Query: 437 KGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLY 496
E + +LN + FD+L E VEKIKTIG +MA +GL + DH
Sbjct: 273 SPTELVELLNTIFCLFDQLAE---LHKVEKIKTIGDAYMAVAGLPNQSK-------DHAL 322
Query: 497 QLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASR 556
+ + AL+MQ + FN + + F +RIG + G V AGVIG K YD+WGD VN ASR
Sbjct: 323 AIANMALDMQNAIAIFNAENNQL-FSIRIGISTGPVVAGVIGLKKFAYDLWGDTVNTASR 381
Query: 557 MDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLL 601
M+S G+ IQV EA +L +Y F+ RG + VKGK +M Y+L
Sbjct: 382 MESHGIAGNIQVCEATYQLLKDKYLFDKRGLIQVKGKGEMMTYIL 426
>UniRef50_A7BXS6 Cluster: Adenylate/guanylate cyclase; n=1;
Beggiatoa sp. PS|Rep: Adenylate/guanylate cyclase -
Beggiatoa sp. PS
Length = 430
Score = 142 bits (344), Expect = 2e-32
Identities = 79/222 (35%), Positives = 127/222 (57%), Gaps = 14/222 (6%)
Query: 385 RNQADWLLHNIIPRHVADQLKNTAKYSENH-KDVAIIFASIINFNEMYDESYLKGKEYLR 443
+ +++ LL NI+P +A +LK + +H +V ++FA I+ F ++ + L K+ +
Sbjct: 221 QEKSERLLLNILPLSIAQRLKQEEQIIADHFTNVTVLFADIVGFTQLSER--LSAKKLVE 278
Query: 444 ILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFAL 503
+LNE+ + FD+L+E+ +EKIKTIG +M GL + D + + + AL
Sbjct: 279 LLNEIFSTFDKLVEK---HGLEKIKTIGDAYMVVGGLPVPIE-------DSVTPIAEMAL 328
Query: 504 EMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVP 563
+MQ+ + FN + +D +RIG + G V AGVIG K YD+WGD VN ASRM+S G+
Sbjct: 329 DMQEALAQFNRR-YHYDLKIRIGIHNGAVVAGVIGLKKFAYDLWGDTVNTASRMESHGIA 387
Query: 564 QRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLLVGKK 605
IQV L +Y RG++ +KGK +M Y+L G++
Sbjct: 388 GCIQVSNRVYDALEDKYVLTKRGTIEIKGKGEMITYMLKGRQ 429
>UniRef50_A0YIQ8 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC
8106|Rep: Adenylate cyclase - Lyngbya sp. PCC 8106
Length = 358
Score = 138 bits (335), Expect = 3e-31
Identities = 89/232 (38%), Positives = 128/232 (55%), Gaps = 16/232 (6%)
Query: 377 DKQRVQNMRNQADWLLHNIIPRHVADQLKNT-AKYSENHKDVAIIFASIINFNEMYDESY 435
D RV+ + +++ LL NI+P+ +A+QLK ++ + I+FA I +F + S
Sbjct: 134 DALRVE--KEKSEQLLLNILPQAIAEQLKKQPGLIADRFEQATILFADITDFTGL--ASQ 189
Query: 436 LKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHL 495
+ E + +LN++ + FD L ER +EKIKTIG +M GL P R DH
Sbjct: 190 ISPTELVSLLNQIFSSFDRLAER---HGLEKIKTIGDAYMVVGGL-PKPRT------DHA 239
Query: 496 YQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIAS 555
+ D AL+MQ+ + F + + +RIG N G V AGVIG K YD+WGDAVNIAS
Sbjct: 240 EAIADMALDMQQEIYRFKREDNKI-LNIRIGINTGPVVAGVIGLKKFSYDLWGDAVNIAS 298
Query: 556 RMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLLVGKKDT 607
RM+S G IQV + +L +Y E RG V VKG+ +M Y L ++ T
Sbjct: 299 RMESHGKIGEIQVSSSTYELLKHKYVLEKRGIVQVKGRGEMITYWLKSRQPT 350
>UniRef50_Q8YZ26 Cluster: Adenylate cyclase; n=1; Nostoc sp. PCC
7120|Rep: Adenylate cyclase - Anabaena sp. (strain PCC
7120)
Length = 472
Score = 136 bits (330), Expect = 1e-30
Identities = 85/226 (37%), Positives = 121/226 (53%), Gaps = 21/226 (9%)
Query: 387 QADWLLHNIIPRHVADQLKNTAK--------YSENHKDVAIIFASIINFNEMYDESYLKG 438
Q++ LL NI+P+ +A++LK + ++ D ++FA I+ F ++ +
Sbjct: 254 QSEKLLLNILPQAIAERLKQSQPSPQTSQMMIADGFSDATVMFADIVGFTDL--SGRIPP 311
Query: 439 KEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQL 498
+ + +LN++ + FD L E ++EKIKTIG +M GL P+ R DH +
Sbjct: 312 QRLVDLLNQIFSRFDLLAES---YNLEKIKTIGDAYMVVGGL-PNPRP------DHAIAI 361
Query: 499 MDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMD 558
L++ + FN D E F +RIG N G V AGVIG K YD+WGD VNIASRM+
Sbjct: 362 AHMGLDILDAIAQFNLDTGE-QFKIRIGINSGPVVAGVIGIKKFIYDLWGDTVNIASRME 420
Query: 559 STGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLLVGK 604
S G P RI V A +L + FE RG +KGK DM Y L GK
Sbjct: 421 SHGTPNRIHVSAASHELLKDSFLFEDRGVTAIKGKGDMQTYWLKGK 466
>UniRef50_Q15T90 Cluster: Adenylate/guanylate cyclase; n=1;
Pseudoalteromonas atlantica T6c|Rep: Adenylate/guanylate
cyclase - Pseudoalteromonas atlantica (strain T6c /
BAA-1087)
Length = 407
Score = 136 bits (328), Expect = 2e-30
Identities = 84/235 (35%), Positives = 132/235 (56%), Gaps = 16/235 (6%)
Query: 371 NVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNT-AKYSENHKDVAIIFASIINFNE 429
N+ + K + N R++A LL NI+PR +A +LK K ++ + V+I F + NF+
Sbjct: 186 NMTRTQQKLFMANQRSEA--LLLNILPRPIAQRLKTVQGKIADQYDQVSICFLDLENFSL 243
Query: 430 MYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASR 489
+ LK + + +L+++ + FD L E +EKIKTIG +MAA+G+ PD+ +A
Sbjct: 244 LVKT--LKAQALVDLLDDVFSQFDRLSEH---HGLEKIKTIGDGYMAAAGV-PDINNA-- 295
Query: 490 GTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGD 549
H Q +AL ++ H + LRIG G+V AGVIG +K YD+WG+
Sbjct: 296 ----HAVQCCAYALAVKDAFSALQHK-YHLTTGLRIGIGSGEVVAGVIGRSKFCYDLWGE 350
Query: 550 AVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLLVGK 604
AV +A+RM+S G +IQV ++ + +Y FEPRG V +KG + Y L+G+
Sbjct: 351 AVTLAARMESHGRTDQIQVTQSTYEMAKHKYCFEPRGEVKIKGLGQIKTYWLLGE 405
>UniRef50_Q8F690 Cluster: Adenylate cyclase; n=4; Leptospira|Rep:
Adenylate cyclase - Leptospira interrogans
Length = 492
Score = 133 bits (321), Expect = 1e-29
Identities = 78/226 (34%), Positives = 128/226 (56%), Gaps = 13/226 (5%)
Query: 381 VQNMRNQADWLLHNIIPRHVADQLK-NTAKYSENHKDVAIIFASIINFNEMYDESYLKGK 439
++ R +++ LL NI+P+ A++LK ++ K ++FA I+ F+++ +
Sbjct: 279 LEKERQKSESLLLNILPKSTAERLKAGEVVIADYIKKSTVLFADIVGFSKLSTQIPTPN- 337
Query: 440 EYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLM 499
+ + ILN++ FD++ + Q +EKIKTIG +M A G+ T DH+ ++
Sbjct: 338 QLVEILNQIFTCFDDIASKYQ---LEKIKTIGDCYMMAGGI-------PIATEDHVEKIA 387
Query: 500 DFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDS 559
++M + + + ++++F +RIG + GDV AGVIG K YD+WGD+VN ASRM+S
Sbjct: 388 LAGIDMIQGLKDLQKS-WKYEFNIRIGIHTGDVVAGVIGKNKFVYDLWGDSVNTASRMES 446
Query: 560 TGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLLVGKK 605
G P RI EA + + FE RG + VKGK M + L+GKK
Sbjct: 447 HGEPGRIHCSEAVYESIKDLFLFEERGVIPVKGKGPMRTFFLLGKK 492
>UniRef50_Q8F1T7 Cluster: Adenylate cyclase; n=2; Leptospira
interrogans|Rep: Adenylate cyclase - Leptospira
interrogans
Length = 418
Score = 131 bits (316), Expect = 6e-29
Identities = 83/251 (33%), Positives = 137/251 (54%), Gaps = 11/251 (4%)
Query: 357 NREFEISYRLSF-YSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHK 415
N ++I + S Y V ++R+Q+ R+++D LLHNI+P +A +LK + S +
Sbjct: 160 NEAWQIIFEQSKDYQENVNEIFEKRLQDARDESDRLLHNILPVSIAAELKKNNRVSPVYI 219
Query: 416 DVA-IIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTF 474
+ A ++F F ++ + + +E + L+E + FD++ +EKIKTIG +F
Sbjct: 220 NSATVLFTDFKGFTQISES--MSPEELISNLDECFSLFDQICAD---HGLEKIKTIGDSF 274
Query: 475 MAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTA 534
M G+ P++ +D + +QK+ + N + + + +RIG++ G V A
Sbjct: 275 MCVGGV-PEVNRTH--VFDVALAALKMCDAIQKLKEEKNKNGISY-WDVRIGFHTGPVAA 330
Query: 535 GVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKD 594
GVIG K YDIWGD VNIASRM+S+G P +I V E +LS + F RG + K K
Sbjct: 331 GVIGKNKFSYDIWGDTVNIASRMESSGEPGKINVSEESYKLLSPFFTFTSRGKIAAKNKG 390
Query: 595 DMNVYLLVGKK 605
++++Y L G K
Sbjct: 391 EISMYFLEGLK 401
>UniRef50_Q7WWV9 Cluster: Putative regulatory protein; n=1;
Ralstonia eutropha H16|Rep: Putative regulatory protein
- Ralstonia eutropha (strain ATCC 17699 / H16 / DSM 428
/ Stanier 337)(Cupriavidus necator (strain ATCC 17699 /
H16 / DSM 428 / Stanier337))
Length = 412
Score = 130 bits (315), Expect = 8e-29
Identities = 87/259 (33%), Positives = 135/259 (52%), Gaps = 22/259 (8%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKY------ 410
N E + S+ L R+ + ++ LL N++P +A++LK
Sbjct: 163 NEELQASWELIRRQRDELQSLYDRILAEQKLSERLLLNLLPYPIAERLKARPDLIASGVP 222
Query: 411 ---SENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKI 467
+++ +V ++FA I+ F + + ++ + ILNE+ +FD + E + +EKI
Sbjct: 223 ELIADSFPEVTVLFADIVAFTRF--SAGMSPEQLVAILNEIFTEFDTIAE---VRGLEKI 277
Query: 468 KTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGY 527
KTIG +MAA+GL P+ DH + AL M + +FN F+ +RIG
Sbjct: 278 KTIGDAYMAAAGL-PE------PAPDHAVRAAHMALNMSDALMHFNQHT-GFNLQMRIGI 329
Query: 528 NFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGS 587
N G V AGVIG K YD+WG AVNIASRM+S GV R+QV +A +L ++FE RGS
Sbjct: 330 NSGAVVAGVIGKRKFIYDLWGAAVNIASRMESHGVAGRVQVTDATRRLLGESFQFEERGS 389
Query: 588 VYVKGKDDMNVYLLVGKKD 606
+ KG ++ + L G+ D
Sbjct: 390 IEAKGIGALHTWFLTGRND 408
>UniRef50_UPI00015B5520 Cluster: PREDICTED: similar to adenylate
cyclase; n=1; Nasonia vitripennis|Rep: PREDICTED: similar
to adenylate cyclase - Nasonia vitripennis
Length = 1092
Score = 128 bits (309), Expect = 4e-28
Identities = 91/262 (34%), Positives = 135/262 (51%), Gaps = 25/262 (9%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK------Y 410
+R+ E RL + +++ + RN LL NI+P HVAD N + Y
Sbjct: 821 DRQAEYLNRLDYQWKRQLTKEQDEAFHTRNANKLLLRNILPEHVADFYLNMDRADEHTLY 880
Query: 411 SENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQ-HVEKIKT 469
E H +VA++FA++ + + DES + L N++I FD+LL + +EKIK
Sbjct: 881 HEAHDNVAVMFATLTDLS--IDESNI-----LVDFNQIICHFDKLLFESNYVCRIEKIKL 933
Query: 470 IGSTFMAASGLNPDLRHASRGT---------YDHLYQLMDFALEMQKVVDNFNHDLFEFD 520
G+T+MAA GL RH+++ + Y+ + ++ FA EM V+++
Sbjct: 934 AGTTYMAACGLEVSRRHSTQSSSSTSESDVKYNVVRVMVQFAAEMMYVLESIKMQTTR-P 992
Query: 521 FILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR- 579
+ LRIG G+VTAGV+G K YDIWGDAVN+ASRMD+TG +IQV VL
Sbjct: 993 YKLRIGIAHGEVTAGVVGAQKPLYDIWGDAVNMASRMDTTGEVGKIQVTTETAEVLKDEG 1052
Query: 580 YEFEPRGSVYVKGKDDMNVYLL 601
RG +VK K + Y +
Sbjct: 1053 IRCHLRGDTWVKPKGYVTTYFV 1074
Score = 79.4 bits (187), Expect = 3e-13
Identities = 52/180 (28%), Positives = 92/180 (51%), Gaps = 18/180 (10%)
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
Y E H++V+I++A ++NF+ + L K+ + LN+L FDE ER +V +IK
Sbjct: 304 YVETHENVSILYADVVNFSGL--TVTLPVKKLVETLNDLFGSFDEASER---HNVLRIKF 358
Query: 470 IGSTFMAASGLN-PDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFE---FDFILRI 525
+G + SG+ P+ +HA +D L+M +++ + D +RI
Sbjct: 359 LGDCYYCVSGVPIPNSQHAK--------SCVDLGLDMINIINAVRARVQRESGVDVNMRI 410
Query: 526 GYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEP 584
G + G + +G++GT K YD+W V IA++M+ TG ++ V + + +L Y P
Sbjct: 411 GVHSGKIISGILGTNKWQYDVWSRDVIIANKMEQTGEAGKVHVTQQTLDLLDVNSYNCSP 470
>UniRef50_Q1NSQ3 Cluster: Adenylate cyclase; n=1; delta
proteobacterium MLMS-1|Rep: Adenylate cyclase - delta
proteobacterium MLMS-1
Length = 480
Score = 128 bits (308), Expect = 6e-28
Identities = 81/234 (34%), Positives = 124/234 (52%), Gaps = 16/234 (6%)
Query: 376 RDKQRVQNMRNQA-DWLLHNIIPRHVADQLKNTAKY-SENHKDVAIIFASIINFNEMYDE 433
R+K+R ++NQ + LL NI+P +A +LK+ + ++ H+ V +IF + F Y
Sbjct: 250 REKERELALQNQENERLLANILPGPIALRLKSGEELIADAHELVTVIFIDMTGFTR-YSA 308
Query: 434 SYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNP-DLRHASRGTY 492
S+ + + LN + D+L + +EKIKTIG +M GL+P D H R
Sbjct: 309 SH-PARRVVDTLNRIFRMIDDLTLK---YRLEKIKTIGDAYMMVGGLDPMDDNHPRR--- 361
Query: 493 DHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVN 552
+ D ALE+ + D +L DF +R+G G V +GVIG+ K YD+WGD VN
Sbjct: 362 -----VADMALELMREFDRLKQELQVTDFSIRVGIATGPVVSGVIGSVKFAYDLWGDTVN 416
Query: 553 IASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLLVGKKD 606
A+R++S+ +P RI L Y FE RG + +KGK M+ L+G+ D
Sbjct: 417 AANRLESSALPGRIHCNARFAHRLQEHYRFEDRGEIEIKGKGVMHTCFLLGQGD 470
>UniRef50_A7C2F8 Cluster: Rh-like protein/ammonium transporter; n=1;
Beggiatoa sp. PS|Rep: Rh-like protein/ammonium
transporter - Beggiatoa sp. PS
Length = 391
Score = 127 bits (307), Expect = 7e-28
Identities = 82/232 (35%), Positives = 123/232 (53%), Gaps = 17/232 (7%)
Query: 377 DKQRVQNMRNQADWLLHNIIPRHVADQLKN-TAKYSENHKDVAIIFASIINFNEMYDESY 435
+K +Q QA+ LL NI P+ +A +LK ++ +V ++FA I F M +
Sbjct: 168 EKIALQTANEQAENLLLNIFPKPIAQRLKKGETVITDTFAEVTVLFADISGFTNM--STQ 225
Query: 436 LKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLN-PDLRHASRGTYDH 494
+ + + LN ++ D +E+ +EKIKTIG +MA +G+ P HA R
Sbjct: 226 IPPHQLVETLNLFFSEIDLQVEK---YGIEKIKTIGDCYMAVAGIPFPCSNHAVR----- 277
Query: 495 LYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIA 554
+ + AL++ ++ N+ ++ +RIG + G V AGVIG K YD+WGD VN A
Sbjct: 278 ---IAEIALDIHEMAKNY--EMLGKPLQMRIGLHSGPVIAGVIGKRKFIYDLWGDTVNTA 332
Query: 555 SRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLLVGKKD 606
SRM+S G+P QV E L Y FE R + VKGK +M VYLL +K+
Sbjct: 333 SRMESHGIPGETQVTEGTYLRLKTDYIFETRPPIMVKGKGEMPVYLLKARKN 384
>UniRef50_Q47AI8 Cluster: Adenylyl cyclase class-3/4/guanylyl
cyclase; n=1; Dechloromonas aromatica RCB|Rep: Adenylyl
cyclase class-3/4/guanylyl cyclase - Dechloromonas
aromatica (strain RCB)
Length = 431
Score = 127 bits (306), Expect = 1e-27
Identities = 74/227 (32%), Positives = 128/227 (56%), Gaps = 14/227 (6%)
Query: 381 VQNMRNQADWLLHNIIPRHVADQLKNTAK-YSENHKDVAIIFASIINFNEMYDESYLKGK 439
+Q+ + +++ LL NI+P +A++LK+ ++ ++ DV ++F I+NF + + + +
Sbjct: 208 LQDEQERSERLLLNILPGPIAERLKHDSQAIADGFADVTVMFVDIVNFTRIAEG--MTPQ 265
Query: 440 EYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLM 499
+ +LN + + FDEL E+ +EKIKTIG +M A GLN +L + ++ + +
Sbjct: 266 QVFAMLNRIFSSFDELAEQ---YGMEKIKTIGDAYMVAGGLNNELNNYTQSIAELAIAMR 322
Query: 500 DFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDS 559
D L V++ + D+ RIG G V AGV+G K YD+WGD VN+ASR+ S
Sbjct: 323 DL-LHRDFTVNDMHLDV-------RIGIGTGPVVAGVVGKKKFIYDLWGDTVNLASRITS 374
Query: 560 TGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLLVGKKD 606
G P IQ+ L+ + F+ ++++KGK + VY L+G +D
Sbjct: 375 EGTPGMIQLDATTYHRLAGHFAFDEPQTLHLKGKGNTVVYRLIGLQD 421
>UniRef50_Q5UFR4 Cluster: Cya1625; n=1; Mycobacterium smegmatis|Rep:
Cya1625 - Mycobacterium smegmatis
Length = 369
Score = 126 bits (303), Expect = 2e-27
Identities = 84/223 (37%), Positives = 123/223 (55%), Gaps = 17/223 (7%)
Query: 387 QADWLLHNIIPRHVADQLKNTAK--YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRI 444
+++ LL NI+P +A +LK+ A+ ++ + D +I+FA I + + E+ + +R
Sbjct: 139 RSEKLLANILPATIATRLKDPARTIIADRYDDASILFADIAGYTKRASET--APCDLVRF 196
Query: 445 LNELIADFDELLERPQFQH-VEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFAL 503
L+ L D D L+E QH +EK+KT G ++M G+ P+ R DH L AL
Sbjct: 197 LDTLYTDLDALVE----QHCLEKVKTSGDSYMVVGGI-PEPRT------DHAEALAALAL 245
Query: 504 EMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVP 563
+M V + D LRIG G V AGV+G + +YD+WGDAVN+ASRM+ST V
Sbjct: 246 DMAAAVADLT-DPEGRRVPLRIGLAAGPVVAGVVGARRFFYDVWGDAVNVASRMESTDVE 304
Query: 564 QRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLLVGKKD 606
RIQV + L + E RG V VKGK M + LVG++D
Sbjct: 305 GRIQVPDDMCLRLRHAFVLEERGEVEVKGKGVMRTWYLVGRRD 347
>UniRef50_A1ZSW5 Cluster: Adenylate cyclase; n=1; Microscilla marina
ATCC 23134|Rep: Adenylate cyclase - Microscilla marina
ATCC 23134
Length = 408
Score = 125 bits (302), Expect = 3e-27
Identities = 74/233 (31%), Positives = 128/233 (54%), Gaps = 10/233 (4%)
Query: 370 SNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKY-SENHKDVAIIFASIINFN 428
SN + R K++++ + ++D LL NI+P +A++LK + + + N+ V+++FA I F
Sbjct: 152 SNRLIQRKKEQIKQEKAKSDELLLNILPEDIAEELKASGRSEARNYNTVSVLFADIKGFT 211
Query: 429 EMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHAS 488
++ + + ++ L FDE++E+ + +EKIKTIG +MAA G+ S
Sbjct: 212 TAAEK--MSAADVVKHLEYYFTAFDEIMEKYE---LEKIKTIGDAYMAAGGIPQPNTSNS 266
Query: 489 RGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWG 548
++ +F + K ++DL + LR+G N G + AGVIG K YD+WG
Sbjct: 267 LEMVCAALEMQNF-MRQHKEARRSSNDLC---WELRLGINTGPLVAGVIGKNKFAYDVWG 322
Query: 549 DAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLL 601
D VN ASRM+S G ++ + ++ +E E RG V VKGK ++++Y +
Sbjct: 323 DTVNTASRMESNGEVNKVNISGVTHQLVKDYFECEYRGKVNVKGKGEVDMYFV 375
>UniRef50_P0A4Y1 Cluster: Adenylate cyclase; n=15;
Mycobacterium|Rep: Adenylate cyclase - Mycobacterium
bovis
Length = 443
Score = 124 bits (300), Expect = 5e-27
Identities = 78/223 (34%), Positives = 122/223 (54%), Gaps = 17/223 (7%)
Query: 386 NQADWLLHNIIPRHVADQLKNTAK--YSENHKDVAIIFASIINFNEMYDESYLKGKEYLR 443
++++ LL N++P +A++LK + ++ + + +++FA I+ F E S + +R
Sbjct: 217 DRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTER--ASSTAPADLVR 274
Query: 444 ILNELIADFDELLERPQFQH-VEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFA 502
L+ L + FDEL++ QH +EKIK G ++M SG+ R DH L DFA
Sbjct: 275 FLDRLYSAFDELVD----QHGLEKIKVSGDSYMVVSGV-------PRPRPDHTQALADFA 323
Query: 503 LEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGV 562
L+M V D LR+G G V AGV+G+ + +YD+WGDAVN+ASRM+ST
Sbjct: 324 LDMTNVAAQLK-DPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDS 382
Query: 563 PQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLLVGKK 605
+IQV + L + RG + VKGK M + L+G+K
Sbjct: 383 VGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRK 425
>UniRef50_Q28S34 Cluster: Adenylate/guanylate cyclase; n=1;
Jannaschia sp. CCS1|Rep: Adenylate/guanylate cyclase -
Jannaschia sp. (strain CCS1)
Length = 417
Score = 123 bits (296), Expect = 2e-26
Identities = 80/204 (39%), Positives = 118/204 (57%), Gaps = 15/204 (7%)
Query: 391 LLHNIIPRHVADQLKNT--AKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNEL 448
LL++++PR +A +LK +++ +VAI+FA I NF + + L + + +LN +
Sbjct: 214 LLYSLLPREIAGRLKAEPHTTIADSLPNVAIVFADIANFTPL--SARLDPRRVVDLLNGV 271
Query: 449 IADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKV 508
+FD L +R Q +EKIKTIG +M A+G+ P+ S G H + D AL+M +V
Sbjct: 272 FTEFDGLADRHQ---LEKIKTIGDAYMVAAGM-PN----SCGNPAH--RAADMALDMLEV 321
Query: 509 VDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQV 568
+ L E F +RIG + G V AGVIG KL+YD+WG+ VN ASRM++ P RI +
Sbjct: 322 ARATSVALPE-GFEIRIGLHVGPVVAGVIGNRKLFYDVWGETVNTASRMETYSAPGRILI 380
Query: 569 GEACVPVLSARYEFEPRGSVYVKG 592
A L + FEPRG + VKG
Sbjct: 381 TPAARAQLGEDFMFEPRGEIDVKG 404
>UniRef50_A0LXB4 Cluster: Secreted protein containing
adenylate/guanylate cyclase catalytic domain; n=1;
Gramella forsetii KT0803|Rep: Secreted protein
containing adenylate/guanylate cyclase catalytic domain
- Gramella forsetii (strain KT0803)
Length = 610
Score = 122 bits (295), Expect = 2e-26
Identities = 77/239 (32%), Positives = 129/239 (53%), Gaps = 15/239 (6%)
Query: 371 NVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKY-SENHKDVAIIFASIINFNE 429
N R ++ +N+++ LL NI+P A +LK K ++ + V ++FA F
Sbjct: 377 NRFIKRTSAIIEKEKNRSELLLLNILPEETARELKKNGKVRAKKFESVTVLFADFKRFTL 436
Query: 430 MYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASR 489
+ + L + ++ ++ + FD+++E+ +EKIKTIG ++MAASGL
Sbjct: 437 IAEN--LPPERLIKTIDYYFSQFDKIMEK---YDIEKIKTIGDSYMAASGL-------PF 484
Query: 490 GTYDHLYQLMDFALEM-QKVVDNFNHDLFE-FDFILRIGYNFGDVTAGVIGTTKLYYDIW 547
DH Y+++ A EM Q V + + L++ +F +R+G N G V AGV+GT K YDIW
Sbjct: 485 PNQDHAYKILMAAFEMTQFVKETKENSLYDDANFDVRVGLNSGPVVAGVVGTKKFAYDIW 544
Query: 548 GDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLLVGKKD 606
GD VNIA+RM+S +I + E ++ +++ E RG V VK + +Y + K+
Sbjct: 545 GDTVNIAARMESHSDIGKINISENTYDLIKDKFDCEYRGEVEVKNGRILKMYYVKDIKE 603
>UniRef50_Q394B3 Cluster: Adenylate/guanylate cyclase; n=4;
Burkholderiaceae|Rep: Adenylate/guanylate cyclase -
Burkholderia sp. (strain 383) (Burkholderia cepacia
(strain ATCC 17760/ NCIB 9086 / R18194))
Length = 395
Score = 121 bits (292), Expect = 5e-26
Identities = 81/240 (33%), Positives = 129/240 (53%), Gaps = 17/240 (7%)
Query: 367 SFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKY-SENHKDVAIIFASII 425
S Y+ VVA + K + + N + + + H+ D + + ++ DV+++FA I+
Sbjct: 165 SLYAKVVAEQ-KVSERLLLNMLPYPIAERLKVHLDDIAGSFPEVIADRFADVSVLFADIV 223
Query: 426 NFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLN-PDL 484
+F + ++ ++ + +LNE+ FD + + +EKIKTIG +MAA+GL P
Sbjct: 224 DFTGF--SAGMRPEQLVEMLNEIFTGFDTIADHCG---LEKIKTIGDAYMAAAGLPVPAA 278
Query: 485 RHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYY 544
HA+R + AL+M + FN + LRIG N G+V AGVIG K Y
Sbjct: 279 DHATRAAH--------MALDMIDALARFNAAR-HCNLKLRIGINSGEVVAGVIGKRKFIY 329
Query: 545 DIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLLVGK 604
D+WG AVN+ASRM+S GV R+QV +A +L + FE RG + KG + + +VG+
Sbjct: 330 DLWGAAVNLASRMESQGVAGRVQVTDATRVMLGEAFVFEERGLIAAKGMGEFRTWFVVGR 389
>UniRef50_Q0LMK3 Cluster: Adenylyl cyclase class-3/4/guanylyl
cyclase; n=1; Herpetosiphon aurantiacus ATCC 23779|Rep:
Adenylyl cyclase class-3/4/guanylyl cyclase -
Herpetosiphon aurantiacus ATCC 23779
Length = 355
Score = 119 bits (286), Expect = 3e-25
Identities = 80/218 (36%), Positives = 116/218 (53%), Gaps = 16/218 (7%)
Query: 387 QADWLLHNIIPRHVADQLKNT-AKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLRIL 445
Q++ LL NI+P+ +ADQLK+ A +E V+++FA I+ F E+ ++ KE + L
Sbjct: 145 QSNRLLRNILPQTIADQLKDQQANIAEYFSSVSVLFADIVGFTEL--SGHINAKELVAWL 202
Query: 446 NELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEM 505
N L + FD++ +EKIKTIG +M A+GL P + DH +L FA M
Sbjct: 203 NRLFSRFDQMTLDVG---LEKIKTIGDAYMVAAGL-PIAQP------DHAERLALFATSM 252
Query: 506 QKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQR 565
++ + +RIG + G V AGVIGT K YD+WGD VNIASRM+S+ P
Sbjct: 253 LAEIEQITMPNGK-PLQMRIGIHSGPVVAGVIGTIKFSYDLWGDTVNIASRMESSAHPNT 311
Query: 566 IQVGEACVPVLS--ARYEFEPRGSVYVKGKDDMNVYLL 601
IQV +L + +PR V +K Y+L
Sbjct: 312 IQVSAETYALLQDHEHFSLQPRHGVEMKHLGTRTTYIL 349
>UniRef50_Q89SW2 Cluster: Two-component hybrid sensor and regulator;
n=3; Bacteria|Rep: Two-component hybrid sensor and
regulator - Bradyrhizobium japonicum
Length = 527
Score = 118 bits (285), Expect = 3e-25
Identities = 76/224 (33%), Positives = 116/224 (51%), Gaps = 14/224 (6%)
Query: 379 QRVQNMRNQADWLLHNIIPRHVADQLKN-TAKYSENHKDVAIIFASIINFNEMYDESYLK 437
+R++ + + LL I+PR V +L + A ++ + V+++FA ++ F E S +
Sbjct: 314 RRIEEETAKFERLLLTILPRQVIGRLNHGEAMIADRFEGVSVLFADLVGFTE--HSSRVT 371
Query: 438 GKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQ 497
+ LN L ++FD L VEKIKTIG +MA +GL PD D +
Sbjct: 372 PAAMVEYLNRLFSEFDALARE---LGVEKIKTIGDAYMAVAGL-PDPNP------DAIAA 421
Query: 498 LMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRM 557
+ AL M + N F + +RIG + G V AG+IG + YD+WGD VN+ASR+
Sbjct: 422 IAKMALGMIDRLGRVNSH-FGWPLQIRIGIHSGPVVAGIIGAHRFIYDVWGDTVNVASRL 480
Query: 558 DSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLL 601
++ +P RI V L R+ EPRGS+ VKGK + + L
Sbjct: 481 EAYSLPNRIHVSRDIARHLVGRFALEPRGSIDVKGKGKLETFFL 524
>UniRef50_A1ZW48 Cluster: Adenylate cyclase; n=1; Microscilla marina
ATCC 23134|Rep: Adenylate cyclase - Microscilla marina
ATCC 23134
Length = 544
Score = 118 bits (283), Expect = 6e-25
Identities = 76/243 (31%), Positives = 128/243 (52%), Gaps = 16/243 (6%)
Query: 363 SYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYS-ENHKDVAIIF 421
SYR N + +R + + + +++ LL NI+PR VA++LK + K S ++ V+++F
Sbjct: 280 SYRRQKKVNQIISRQQAEIVEAKERSETLLLNILPREVAEELKESGKASIRQYEMVSVLF 339
Query: 422 ASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLN 481
F + ++ + +R L FDE++E+ ++EKIKTIG +MAA G+
Sbjct: 340 TDFKGFTSIAEK--ITPVALVRELETCFLRFDEIIEK---YNIEKIKTIGDAYMAAGGI- 393
Query: 482 PDLRHASRGTYDHLYQLMDFALEMQKVVDNFN---HDLFEFDFILRIGYNFGDVTAGVIG 538
P + ++ LEMQ+ ++ E + LR+G N G + AGVIG
Sbjct: 394 PIANQTNP------LDVILAGLEMQRYMNELKAAKQAAGEPYWELRLGINTGKLIAGVIG 447
Query: 539 TTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNV 598
K YD+WGD VN ASRM+S+G ++ + ++ +E E RG V KGK ++++
Sbjct: 448 KKKFAYDVWGDTVNTASRMESSGEVGKVNISGKTYELVKDFFECEHRGKVTAKGKGEIDM 507
Query: 599 YLL 601
Y +
Sbjct: 508 YFV 510
>UniRef50_A4AWH6 Cluster: Adenylate/guanylate cyclase; n=1;
Flavobacteriales bacterium HTCC2170|Rep:
Adenylate/guanylate cyclase - Flavobacteriales bacterium
HTCC2170
Length = 394
Score = 117 bits (282), Expect = 8e-25
Identities = 64/232 (27%), Positives = 124/232 (53%), Gaps = 14/232 (6%)
Query: 371 NVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK-YSENHKDVAIIFASIINFNE 429
+V+ ++ ++ + + ++D LLHNI+P ++ LK + K + HKD+ ++F NF +
Sbjct: 175 SVLIDKSEESLMAEQKKSDDLLHNILPANIIRDLKESGKTIPKRHKDITVLFTDFENFTK 234
Query: 430 MYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASR 489
+ + + + LN++ FDE++ + VEKI+TIG ++MAA GL ++ + +
Sbjct: 235 LV--ASISAITLVNELNDIFGRFDEIMAETE---VEKIETIGDSYMAACGLEKEMANHAA 289
Query: 490 GTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGD 549
++ + E K +H E + +R+G + G V AGV+G K YD++GD
Sbjct: 290 NCIRAAQMMLSYLEERNK-----SH---EIKWKMRVGIHSGTVVAGVVGKKKFAYDLFGD 341
Query: 550 AVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLL 601
+N ASR++ G +I + + + ++ RG ++ KGK D+ +Y +
Sbjct: 342 TINTASRIEFAGEVGKINISSSTYEQIKNDFKCLSRGKIFAKGKGDLEMYFV 393
>UniRef50_Q03100 Cluster: Adenylate cyclase, aggregation specific;
n=1; Dictyostelium discoideum|Rep: Adenylate cyclase,
aggregation specific - Dictyostelium discoideum (Slime
mold)
Length = 1407
Score = 117 bits (282), Expect = 8e-25
Identities = 80/256 (31%), Positives = 132/256 (51%), Gaps = 28/256 (10%)
Query: 361 EISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK----------Y 410
+++ R ++ N N V +++ ++LL +I P+ +L++ Y
Sbjct: 1122 KLAMRKAWVVNCKINFKTISVNKEKDKFNFLLKSIFPQSALTKLRDMIDTPNIETKGIVY 1181
Query: 411 SENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
+ H+DV+I+F I F E YDE K+ ++ LN++ + FD LL + VEKIKTI
Sbjct: 1182 VQPHQDVSIMFIQIAGFQE-YDEP----KDLIKKLNDIFSFFDGLLNQKYGGTVEKIKTI 1236
Query: 471 GSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFG 530
G+T+MA SGL+ G+ L ++ DFAL+++ ++ ++RIG + G
Sbjct: 1237 GNTYMAVSGLD--------GSPSFLEKMSDFALDVKAYTNSV-----AISRVVRIGISHG 1283
Query: 531 DVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYV 590
+ AG IG ++ +D+WGD N ASRM S I V + L+ + F+ + V
Sbjct: 1284 PLVAGCIGISRAKFDVWGDTANTASRMQSNAQDNEIMVTHSVYERLNKLFYFDDEKEILV 1343
Query: 591 KGKDDMNVYLLVGKKD 606
KGK M ++L GKKD
Sbjct: 1344 KGKGKMVTHVLKGKKD 1359
Score = 50.4 bits (115), Expect = 1e-04
Identities = 29/96 (30%), Positives = 47/96 (48%), Gaps = 5/96 (5%)
Query: 478 SGLNPDLRHASRGTYDHLYQLMDFALEMQKV---VDNFNHDLFEFDFILRIGYNFGDVTA 534
SG + D +H +L+D A+E+ + + N + + F R G G V
Sbjct: 580 SGNDDDDEEIEDSELEHFEKLIDVAIEIMNLDVLKETGNTEGIQVQF--RCGIAAGSVYG 637
Query: 535 GVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGE 570
GVIG+ K +DIWGD + + ++ G P ++ VGE
Sbjct: 638 GVIGSQKYQFDIWGDTIARSHTLEQLGQPGKVHVGE 673
>UniRef50_A1ZSW4 Cluster: Atrial natriuretic peptide receptor A;
n=1; Microscilla marina ATCC 23134|Rep: Atrial
natriuretic peptide receptor A - Microscilla marina ATCC
23134
Length = 562
Score = 117 bits (281), Expect = 1e-24
Identities = 77/224 (34%), Positives = 122/224 (54%), Gaps = 18/224 (8%)
Query: 385 RNQADWLLHNIIPRHVADQLKNTAKYSENHKDVA-IIFASIINFNEMYDESYLKGKEYLR 443
++++D LL NI+P VA++LK K + D+A ++F F ++ S+ E ++
Sbjct: 322 KDKSDKLLLNILPSDVAEELKINGKSQVRNYDMATVMFTDFKGFTKI--ASFTDPAEIVK 379
Query: 444 ILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL-NPDLRHASRGTYDHLYQLMDFA 502
L+ A FD+++E ++EKIKTIG +M G+ N + +A T A
Sbjct: 380 NLDTCFAAFDQIIEE---YNLEKIKTIGDAYMCVGGIPNENKSNAVDATLA--------A 428
Query: 503 LEMQKVVDNFNHDLF---EFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDS 559
L ++K + +F + E + LR+G N G + AGVIGT K YD+WGD VN ASRM+S
Sbjct: 429 LSIRKFMADFRTEKLLRGEQVWELRLGINTGPLIAGVIGTKKFAYDVWGDTVNTASRMES 488
Query: 560 TGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLLVG 603
GV I V + ++ +E E G V KGK ++++YL+ G
Sbjct: 489 NGVVNEISVSQVTYELVKDFFECEYHGRVQAKGKGEIDMYLVKG 532
>UniRef50_A5P0P3 Cluster: Response regulator receiver protein; n=1;
Methylobacterium sp. 4-46|Rep: Response regulator
receiver protein - Methylobacterium sp. 4-46
Length = 531
Score = 116 bits (280), Expect = 1e-24
Identities = 71/221 (32%), Positives = 117/221 (52%), Gaps = 14/221 (6%)
Query: 384 MRNQADWLLHNIIPRHVADQLKN-TAKYSENHKDVAIIFASIINFNEMYDESYLKGKEYL 442
+R + + LL N++PR + +++N A ++ V ++F ++ F + G +
Sbjct: 317 LREREERLLLNVLPRPILARMRNGEAAIADRFAQVTVLFCDLVGFTPLAGRLTPGGT--V 374
Query: 443 RILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFA 502
+L+ + + FD + R + VEKIKTIG +MAA G+ P+ T DH ++ A
Sbjct: 375 DLLSRVFSAFDRSVAR---RGVEKIKTIGDAYMAAGGI-PET------TPDHARRIALLA 424
Query: 503 LEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGV 562
+M V+ L + +R+G + G+ AGVIG ++ YD+WGD+VNIA+RM+S G
Sbjct: 425 FDMMADVEEVGRAL-GVELAVRVGIHSGEAVAGVIGQSRFAYDVWGDSVNIAARMESHGQ 483
Query: 563 PQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLLVG 603
RI + E+ L + PRG ++KGK M Y L G
Sbjct: 484 AGRIHISESTRRALGGDFFCTPRGVTHIKGKGPMETYFLDG 524
>UniRef50_Q7YXG2 Cluster: Soluble guanylyl cyclase 1 beta; n=1;
Limax marginatus|Rep: Soluble guanylyl cyclase 1 beta -
Limax marginatus
Length = 444
Score = 116 bits (280), Expect = 1e-24
Identities = 77/233 (33%), Positives = 118/233 (50%), Gaps = 14/233 (6%)
Query: 376 RDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKY-SENHKDVAIIFASIINFNEMYDES 434
R Q ++ +++ + LLH ++PR VA L + K +E V ++F+ I+ F + S
Sbjct: 16 RTSQALEEEKSKTETLLHQMLPRKVATALTHGQKVEAEKFDQVTVLFSDIVTFTNI--AS 73
Query: 435 YLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDH 494
+ + +LNE+ FDE R +V K++TIG +M SG+ P+ T +H
Sbjct: 74 ACSPMDIVNMLNEMYQRFDE---RTSQHNVYKVETIGDAYMIVSGV-PER------TTNH 123
Query: 495 LYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIA 554
+ DFAL+M + +R+G + G V AGV+G Y ++GD VN A
Sbjct: 124 AQPVADFALDMVEDAGLVRSPATGLPLQIRVGVHTGPVVAGVVGVKMPRYCLFGDTVNTA 183
Query: 555 SRMDSTGVPQRIQVGEACVPVL-SARYEFEPRGSVYVKGKDDMNVYLLVGKKD 606
SRM+S G P RI + L S+ Y F+ RG + VKGK M+ Y L G D
Sbjct: 184 SRMESHGAPGRIHMSPTAYRALCSSGYVFKQRGQMEVKGKGVMSTYFLCGHLD 236
>UniRef50_Q8IQK2 Cluster: Guanylate cyclase; n=6; Diptera|Rep:
Guanylate cyclase - Drosophila melanogaster (Fruit fly)
Length = 1272
Score = 116 bits (278), Expect = 2e-24
Identities = 79/231 (34%), Positives = 119/231 (51%), Gaps = 15/231 (6%)
Query: 380 RVQNMRNQADWLLHNIIPRHVADQLKNTAKYS-ENHKDVAIIFASIINFNEMYDESYLKG 438
++Q + + D LLH ++PR VADQLK K E+++ V+I F+ I+ F M E
Sbjct: 905 QLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAEC--TP 962
Query: 439 KEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQL 498
+ + LN+L FD ++ V K++TIG +M SGL LR+ H ++
Sbjct: 963 LQVVDFLNDLYTCFDSIIGH---YDVYKVETIGDAYMVVSGL--PLRNGDL----HAAEI 1013
Query: 499 MDFALEMQKVVDNFNHDLFEFD-FILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRM 557
+L + V F + +LRIG + G V AGV+G Y ++GD VN ASRM
Sbjct: 1014 ATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRM 1073
Query: 558 DSTGVPQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDMNVYLLVGKKD 606
+S+GVP +I C +L Y F RG + +KGK D Y L+G+ +
Sbjct: 1074 ESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDE 1124
>UniRef50_Q9VN32 Cluster: Guanylate cyclase; n=5; Diptera|Rep:
Guanylate cyclase - Drosophila melanogaster (Fruit fly)
Length = 975
Score = 115 bits (277), Expect = 3e-24
Identities = 84/247 (34%), Positives = 125/247 (50%), Gaps = 19/247 (7%)
Query: 366 LSFYSNVVANRDKQRVQNM---RNQADWLLHNIIPRHVADQLK-NTAKYSENHKDVAIIF 421
L YSN + ++R + + R + + LL+ ++P VA++LK A E DV I F
Sbjct: 348 LEKYSNNLEELIRERTEQLDIERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEFSDVTIYF 407
Query: 422 ASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLN 481
+ I+ F + ++ + + +LN+L FD + +V K++TIG +M SGL
Sbjct: 408 SDIVGFTTI--AAHCSPVQVVDLLNDLYTIFDATINA---YNVYKVETIGDAYMVVSGLP 462
Query: 482 PDLRHASRGTYDHLYQLMDFALEMQKVVDNFN-HDLFEFDFILRIGYNFGDVTAGVIGTT 540
+ DH Q+ AL++ FN L LRIG + G AGV+G T
Sbjct: 463 VKIP-------DHAEQIATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLT 515
Query: 541 KLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR--YEFEPRGSVYVKGKDDMNV 598
Y ++GD VN ASRM+STG RI + + L AR Y EPRG + +KGK MN
Sbjct: 516 MPRYCLFGDTVNTASRMESTGSSWRIHMSQETRDRLDARGGYAIEPRGLIDIKGKGMMNT 575
Query: 599 YLLVGKK 605
+ L+GKK
Sbjct: 576 FWLLGKK 582
>UniRef50_O01779 Cluster: Guanylate cyclase; n=1; Caenorhabditis
elegans|Rep: Guanylate cyclase - Caenorhabditis elegans
Length = 1146
Score = 115 bits (277), Expect = 3e-24
Identities = 80/240 (33%), Positives = 125/240 (52%), Gaps = 17/240 (7%)
Query: 373 VANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYS-ENHKDVAIIFASIINFNEMY 431
V R K+ V+ + ++D LL+ ++P+ VA++LK E + V I F+ ++ F +
Sbjct: 895 VNERTKELVEEQK-KSDVLLYRMLPKTVAEKLKAGISIEPETFELVTIFFSDVVQFTTL- 952
Query: 432 DESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGT 491
S + +++LN+L FD ++E+ V K++TIG ++ SGL R
Sbjct: 953 -ASKCTPLQVVQLLNDLYTIFDSIIEQ---NDVYKVETIGDGYLCVSGL------PHRNG 1002
Query: 492 YDHLYQLMDFALEMQKVVDNFNHDLFEFDFI-LRIGYNFGDVTAGVIGTTKLYYDIWGDA 550
+DH+ + +L + F + I LRIG N G V AGV+G T Y ++GDA
Sbjct: 1003 HDHIKHIARMSLAFLSSLAEFRVAHMPSERINLRIGINCGSVVAGVVGLTMPRYCLFGDA 1062
Query: 551 VNIASRMDSTGVPQRIQVGEACVPVLS---ARYEFEPRGSVYVKGKDDMNVYLLVGKKDT 607
VN ASRM+S G P RI V +L+ + E RG V +KGK MN Y L+G+ D+
Sbjct: 1063 VNTASRMESNGKPGRIHVSSEANHLLTHVVGGFRTEERGEVIIKGKGVMNTYWLLGENDS 1122
>UniRef50_Q8T8L6 Cluster: Guanylate cyclase; n=5; Caenorhabditis|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1276
Score = 115 bits (276), Expect = 4e-24
Identities = 84/250 (33%), Positives = 131/250 (52%), Gaps = 21/250 (8%)
Query: 365 RLSFYSNVVANRDKQRVQNM---RNQADWLLHNIIPRHVADQL-KNTAKYSENHKDVAII 420
R+ Y+N + ++R Q + + + LLH ++P +AD L A +E++ V I
Sbjct: 1029 RMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIY 1088
Query: 421 FASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL 480
F+ I+ F + +S + + +LN+L FD +++ F+ V K++TIG +M SGL
Sbjct: 1089 FSDIVGFTSLSSQS--TPMQVVTLLNDLYLAFDGVVDN--FK-VYKVETIGDAYMVVSGL 1143
Query: 481 NPDLRHASRGTYDHLYQLMDFALEMQKVVDNF--NHDLFEFDFILRIGYNFGDVTAGVIG 538
P+ R DH Q+ +L + V NF H E LRIG + G V AGV+G
Sbjct: 1144 -PERRD------DHANQIAQMSLSLLHKVKNFVIRHRPHE-QLKLRIGMHSGSVVAGVVG 1195
Query: 539 TTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL--SARYEFEPRGSVYVKGKDDM 596
+ Y ++GD VN +SRM+S G+P +I V + +L A ++ E RGSV +KGK
Sbjct: 1196 SKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQ 1255
Query: 597 NVYLLVGKKD 606
Y L G KD
Sbjct: 1256 TTYWLRGYKD 1265
>UniRef50_A3I1K5 Cluster: Adenylate/guanylate cyclase; n=1;
Algoriphagus sp. PR1|Rep: Adenylate/guanylate cyclase -
Algoriphagus sp. PR1
Length = 420
Score = 113 bits (271), Expect = 2e-23
Identities = 73/227 (32%), Positives = 120/227 (52%), Gaps = 20/227 (8%)
Query: 385 RNQADWLLHNIIPRHVADQLKNTAKYSEN-HKDVAIIFASIINFNEMYDESYLKGKEYLR 443
+ +++ LL NI P +A++LK+T + H +V ++FA + NF + E L + +
Sbjct: 207 QERSENLLLNIFPADIAEELKSTGRTQARLHDNVTVLFADVKNFT-IVSEGLLPD-QLVA 264
Query: 444 ILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFAL 503
+L+ D ++++ +EKIKTIG ++AA+G+ + +R ++ AL
Sbjct: 265 LLDTYFQRIDAIIQK---HGLEKIKTIGDAYLAAAGVPKGNKATAR-------DVVAAAL 314
Query: 504 EMQKVVDNFN-----HDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMD 558
E+QK D + L FDF RIG N G V AGV+G K YDIWGDAVN A+R++
Sbjct: 315 EIQKTNDAYKVLRETEGLPFFDF--RIGINTGTVVAGVVGDKKYVYDIWGDAVNTAARIE 372
Query: 559 STGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLLVGKK 605
P R+ + V+ +E E RG + K K + ++ ++G K
Sbjct: 373 ENSAPGRVNISAFTHQVVKEHFELEERGLISAKNKGKIEMFWVLGHK 419
>UniRef50_P25092 Cluster: Heat-stable enterotoxin receptor precursor;
n=41; Euteleostomi|Rep: Heat-stable enterotoxin receptor
precursor - Homo sapiens (Human)
Length = 1073
Score = 113 bits (271), Expect = 2e-23
Identities = 81/250 (32%), Positives = 127/250 (50%), Gaps = 19/250 (7%)
Query: 365 RLSFYSNVVANRDKQRVQNM---RNQADWLLHNIIPRHVADQLKNTAKYS-ENHKDVAII 420
RL YS + + ++R Q R++AD L ++PR V LK E +++V I
Sbjct: 767 RLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIY 826
Query: 421 FASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL 480
F+ I+ F + Y E + +LN++ FD +++ V K++TIG +M ASGL
Sbjct: 827 FSDIVGFTTIC--KYSTPMEVVDMLNDIYKSFDHIVDH---HDVYKVETIGDAYMVASGL 881
Query: 481 NPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHD-LFEFDFILRIGYNFGDVTAGVIGT 539
R+ +R H + ALE+ + F + L +RIG + G AGV+G
Sbjct: 882 PK--RNGNR----HAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGI 935
Query: 540 TKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL---SARYEFEPRGSVYVKGKDDM 596
Y ++GD VN ASRM+STG+P RI V + + +L ++ +E RG Y+KG+ +
Sbjct: 936 KMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNE 995
Query: 597 NVYLLVGKKD 606
Y L G KD
Sbjct: 996 TTYWLTGMKD 1005
>UniRef50_A1ZFP4 Cluster: Two-component hybrid sensor and regulator;
n=1; Microscilla marina ATCC 23134|Rep: Two-component
hybrid sensor and regulator - Microscilla marina ATCC
23134
Length = 1269
Score = 112 bits (270), Expect = 2e-23
Identities = 72/226 (31%), Positives = 116/226 (51%), Gaps = 12/226 (5%)
Query: 378 KQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHKDVA-IIFASIINFNEMYDESYL 436
+Q+++ + + LL NI+P VA+ LK K + ++ ++F F + E +
Sbjct: 1028 EQKIEERTEEINTLLLNILPEEVANDLKTNGKAPVKYYAMSTVLFTDFQGFTKQASE--M 1085
Query: 437 KGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLY 496
KE + LNE A FD+++E+ ++EKIKTIG +MAA G+ P S T
Sbjct: 1086 DSKELVEDLNEYFAGFDDIMEQ---YNLEKIKTIGDAYMAAGGI-PQ----SNTTNPVDA 1137
Query: 497 QLMDFALEMQKVVDNFNHDLFEFDFI-LRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIAS 555
L A++ F +R+G N G+V AGVIGT K YD+WGD+VN A+
Sbjct: 1138 VLAGLAIQQFVAAKRAERKAEGKQFWDVRLGVNTGEVIAGVIGTKKFAYDVWGDSVNTAA 1197
Query: 556 RMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLL 601
RM+S G + + ++ ++ E RG V KGK ++++Y +
Sbjct: 1198 RMESGGKVGEVNISHNTYEMVKDYFDVEHRGKVNAKGKGEVDMYFV 1243
>UniRef50_Q8F778 Cluster: Adenylate cyclase; n=3; Leptospira
interrogans|Rep: Adenylate cyclase - Leptospira
interrogans
Length = 366
Score = 111 bits (268), Expect = 4e-23
Identities = 71/220 (32%), Positives = 124/220 (56%), Gaps = 14/220 (6%)
Query: 385 RNQADWLLHNIIPRHVADQLK-NTAKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLR 443
R ++D LL NI+P VA++LK N +++V ++F + F ++ + + +E L
Sbjct: 124 RKKSDSLLLNILPESVAEELKRNDFVVPIRYENVTVLFTDMAGFTKIAES--MSPEELLS 181
Query: 444 ILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFA- 502
L+ +FD + ++ +EKIKTIG ++MAA GL P + + + D + ++F
Sbjct: 182 ELDLFFREFDLITKK---HGMEKIKTIGDSYMAAGGL-PIVNNTH--SIDAVLCGLEFQK 235
Query: 503 -LEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTG 561
+ ++K NH F + LR+G + G V AGV+GT K YDIWGD+VN ASRM+S+G
Sbjct: 236 FMRLKKKERENNHLPF---WELRLGIHSGSVVAGVVGTKKFAYDIWGDSVNTASRMESSG 292
Query: 562 VPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLL 601
+P + + + + + + RG + K K ++++YL+
Sbjct: 293 IPGEVNISQETFEKIKDFFICDYRGKIKAKNKGEIDMYLV 332
>UniRef50_Q5YLC2 Cluster: Soluble guanylyl cyclase beta; n=1;
Chlamydomonas reinhardtii|Rep: Soluble guanylyl cyclase
beta - Chlamydomonas reinhardtii
Length = 991
Score = 111 bits (268), Expect = 4e-23
Identities = 72/220 (32%), Positives = 113/220 (51%), Gaps = 15/220 (6%)
Query: 385 RNQADWLLHNIIPRHVADQLKNTAKY-SENHKDVAIIFASIINFNEMYDESYLKGKEYLR 443
R ++D LL+ ++P VA LKN + ++ H + ++F+ I+ F E+ S E
Sbjct: 443 RRRSDGLLYQMLPPEVASCLKNEERAPAQEHPEATVLFSDIVGFTEIASRS--SPLEVCS 500
Query: 444 ILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFAL 503
+L+EL FD +E ++ + K++TIG +M + DH L++FAL
Sbjct: 501 LLDELYQRFDAAIE--EYPQLYKVETIGDAYMVVCNVTVPCD-------DHADVLLEFAL 551
Query: 504 EMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVP 563
M + L E +R+G + G V AGV+G + ++GD VN ASRM+S G
Sbjct: 552 RMHEEASRVASSLGE-PVRIRVGMHSGPVVAGVVGRKMPRFCLFGDTVNTASRMESHGEA 610
Query: 564 QRIQVGEACVPVLSA--RYEFEPRGSVYVKGKDDMNVYLL 601
+I + EAC L + R+E RG++ VKGK M YLL
Sbjct: 611 GQIHISEACYCCLRSKERFEIRERGNITVKGKGTMRTYLL 650
>UniRef50_Q98GN7 Cluster: Cyclase; n=1; Mesorhizobium loti|Rep:
Cyclase - Rhizobium loti (Mesorhizobium loti)
Length = 356
Score = 111 bits (267), Expect = 5e-23
Identities = 75/245 (30%), Positives = 127/245 (51%), Gaps = 17/245 (6%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHKDV 417
RE +++ +L N ++ +Q +A+ LL NI+P +A++LK + ++NH +V
Sbjct: 126 RERQLNEKLQSM-NEALRESQEGLQREYQRAETLLLNILPASIAERLKADEQIADNHAEV 184
Query: 418 AIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAA 477
+++FA I+ F E + L ILN D L E+ EKIKTIG M
Sbjct: 185 SVLFADIVGFTERARS--VGAVTTLAILNYFFKAADRLSEQ---YGCEKIKTIGDCVMVV 239
Query: 478 SGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFI-LRIGYNFGDVTAGV 536
+GL P R DH L +ALE+++ V H+ F + + LRIG + G + AGV
Sbjct: 240 AGL-PAARP------DHAEALARYALELREAVQ---HERFAGERLRLRIGIHSGPIVAGV 289
Query: 537 IGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDM 596
IG + YD+WG+ VN+A+R+ ++ P I++ +A +L + +P ++G +
Sbjct: 290 IGKRRFAYDLWGETVNLAARIQTSAEPDEIRISDATRRLLGPDFACDPLAETELRGTGRV 349
Query: 597 NVYLL 601
++ L
Sbjct: 350 RMWRL 354
>UniRef50_Q8MLX0 Cluster: CG3216-PB, isoform B; n=7;
Endopterygota|Rep: CG3216-PB, isoform B - Drosophila
melanogaster (Fruit fly)
Length = 1141
Score = 111 bits (267), Expect = 5e-23
Identities = 78/244 (31%), Positives = 126/244 (51%), Gaps = 18/244 (7%)
Query: 365 RLSFYSNVVANRDKQRVQNM---RNQADWLLHNIIPRHVADQLK-NTAKYSENHKDVAII 420
R+ Y+N + + +++ + + + + + LL+ I+PR VA QL E V I
Sbjct: 877 RMEQYANNLESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIY 936
Query: 421 FASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL 480
F+ I+ F E+ S + + LN+L + FD ++ F V K++TIG ++ SGL
Sbjct: 937 FSDIVGFTELCARS--SPMDVVNFLNDLYSTFDRIIG---FYDVYKVETIGDAYLVVSGL 991
Query: 481 NPDLRHASRGTYDHLYQLMDFALEMQKVVDNFN-HDLFEFDFILRIGYNFGDVTAGVIGT 539
P+ G H ++ AL++ + V +FN E+ +RIG + G V AGV+G
Sbjct: 992 -PE----PNGD-KHAREIALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGK 1045
Query: 540 TKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDMN 597
+Y ++GD VN ASRM+STG P +I V A +L ++ E RG V +KGK +
Sbjct: 1046 KMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAILDKFGTFQMEQRGDVELKGKGTVT 1105
Query: 598 VYLL 601
Y L
Sbjct: 1106 TYWL 1109
>UniRef50_A3HV63 Cluster: Adenylate or guanylate cyclase; n=1;
Algoriphagus sp. PR1|Rep: Adenylate or guanylate cyclase
- Algoriphagus sp. PR1
Length = 638
Score = 111 bits (266), Expect = 7e-23
Identities = 77/234 (32%), Positives = 122/234 (52%), Gaps = 24/234 (10%)
Query: 376 RDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHKD---VAIIFASIINFNEMYD 432
+ ++ + ++++D LL NI+P VA++LK K S + KD V +IF +F +
Sbjct: 413 KSREIISKEKDRSDKLLLNILPAEVAEELKT--KGSSDAKDFDQVTVIFTDFADFTKK-- 468
Query: 433 ESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTY 492
+L KE ++ LN FDE+ +EKIKTIG +MAA GLN +
Sbjct: 469 AQHLSAKELVKELNTCFKTFDEITYN---LGLEKIKTIGDAYMAAGGLN---------SK 516
Query: 493 DHLYQLMDFALEMQKVVDNFNHD---LFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGD 549
+ ++ A++M+K +D N D + F +R G N G V AG++G K YDIWGD
Sbjct: 517 SGVKEVALAAIQMKKFIDERNSDPNISRKIKFDMRCGINSGPVVAGIVGIKKFQYDIWGD 576
Query: 550 AVNIASRMDSTGVPQRIQVGEACVPVL--SARYEFEPRGSVYVKGKDDMNVYLL 601
VN A RM+++ +I + E +L + F RG + VKGK +M ++ +
Sbjct: 577 TVNTAQRMEASCEINQINISENTYSLLKDDPDFTFIERGILPVKGKGEMKMWYI 630
>UniRef50_A1ZQH6 Cluster: Heat-stable enterotoxin receptor; n=1;
Microscilla marina ATCC 23134|Rep: Heat-stable
enterotoxin receptor - Microscilla marina ATCC 23134
Length = 711
Score = 111 bits (266), Expect = 7e-23
Identities = 71/247 (28%), Positives = 127/247 (51%), Gaps = 12/247 (4%)
Query: 357 NREFEIS-YRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHK 415
N+ E+S Y LS N + ++ + ++D LL NI+P A +LK + H
Sbjct: 471 NKMVELSNYELS-EKNEFIQQQNTLIEKEKAKSDELLLNILPEQTATELKEKGYATPQHY 529
Query: 416 D-VAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTF 474
D V+++F F ++ ++ + +E + LN FD++LE+ ++EKIKTIG +
Sbjct: 530 DLVSVLFTDFKGFTKLAEK--ITPQEVIEELNYCFTAFDKILEK---HNLEKIKTIGDAY 584
Query: 475 MAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTA 534
MAA G+ + ++ F + +K + ++E LR+G + G++ A
Sbjct: 585 MAAGGIPLANQTNPVDAVKAGLEMQAFMVHWKKDKEAQGLPVWE----LRLGIHTGEIIA 640
Query: 535 GVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKD 594
GV+G K YDIWGD VN+ASRM+S G ++ + ++ ++ E RG + K K
Sbjct: 641 GVVGKKKFAYDIWGDTVNLASRMESGGEAGKVNISGDTYALIKDHFQCEYRGKINAKNKG 700
Query: 595 DMNVYLL 601
++++Y +
Sbjct: 701 NVDMYFV 707
>UniRef50_Q16JH8 Cluster: Soluble guanylate cyclase gcy; n=2;
Culicidae|Rep: Soluble guanylate cyclase gcy - Aedes
aegypti (Yellowfever mosquito)
Length = 1025
Score = 111 bits (266), Expect = 7e-23
Identities = 72/228 (31%), Positives = 118/228 (51%), Gaps = 16/228 (7%)
Query: 382 QNMRNQADWLLHNIIPRHVADQLK---NTAKYSENHKDVAIIFASIINFNEMYDESYLKG 438
+ MR + D LL+ +IP+ VAD+L+ N E V+I+F+ ++ F E+ S +
Sbjct: 386 EEMR-RTDELLYQMIPKQVADRLRRGENPIDTCEMFNSVSILFSDVVTFTEIC--SRITP 442
Query: 439 KEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQL 498
E + +LN + + FD L ER +V K++TIG +M SG A +H ++
Sbjct: 443 MEVVSMLNAMYSIFDTLTER---NNVYKVETIGDAYMVVSG-------APEKEQNHAEKV 492
Query: 499 MDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMD 558
D AL+M + + + +R+G + G V AG++G Y ++GD+VN ASRM+
Sbjct: 493 CDMALDMIEAITDLKDPSTGSHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDSVNTASRME 552
Query: 559 STGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLLVGKKD 606
ST +I + ++ L + Y RG + VKGK M Y L K++
Sbjct: 553 STSQAMKIHISQSTRNFLPSNYHVSERGEIDVKGKGTMKTYWLDHKEN 600
>UniRef50_Q8INF0 Cluster: Soluble guanylate cyclase 88E; n=12;
Coelomata|Rep: Soluble guanylate cyclase 88E -
Drosophila melanogaster (Fruit fly)
Length = 947
Score = 111 bits (266), Expect = 7e-23
Identities = 72/224 (32%), Positives = 116/224 (51%), Gaps = 18/224 (8%)
Query: 382 QNMRNQADWLLHNIIPRHVADQLK---NTAKYSENHKDVAIIFASIINFNEMYDESYLKG 438
+ MR + D LL+ +IP+ VAD+L+ N E V+I+F+ I+ F E+ S +
Sbjct: 383 EEMR-RTDELLYQMIPKQVADRLRRGENPIDTCEMFDSVSILFSDIVTFTEIC--SRITP 439
Query: 439 KEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL-NPDLRHASRGTYDHLYQ 497
E + +LN + + FD+L ER V K++TIG +M +G + D HA R
Sbjct: 440 MEVVSMLNAMYSIFDKLTER---NSVYKVETIGDAYMVVAGAPDKDANHAER-------- 488
Query: 498 LMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRM 557
+ D AL+M + + +R+G + G V AG++G Y ++GD VN ASRM
Sbjct: 489 VCDMALDMVDAITDLKDPSTGQHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRM 548
Query: 558 DSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLL 601
+ST + ++ + E+ ++ Y+ RG + VKGK M Y L
Sbjct: 549 ESTSIAMKVHISESTKVLIGPNYKIIERGEIDVKGKGTMGTYWL 592
>UniRef50_Q6TL19 Cluster: Guanylate cyclase 2G precursor; n=6;
Murinae|Rep: Guanylate cyclase 2G precursor - Mus
musculus (Mouse)
Length = 1100
Score = 110 bits (265), Expect = 9e-23
Identities = 81/248 (32%), Positives = 131/248 (52%), Gaps = 20/248 (8%)
Query: 365 RLSFYSN----VVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-KNTAKYSENHKDVAI 419
+L Y+N VV R ++ V R + + LL ++P V +QL + E+ + V I
Sbjct: 844 KLETYANHLEEVVEERTRELVAEKR-KVEKLLSTMLPSFVGEQLIAGKSVEPEHFESVTI 902
Query: 420 IFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASG 479
F+ I+ F ++ S + +++LN+L + FD + Q V K++TIG +M ASG
Sbjct: 903 FFSDIVGFTKLCSLS--SPLQVVKLLNDLYSLFDHTI---QSHDVYKVETIGDAYMVASG 957
Query: 480 LNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFN-HDLFEFDFILRIGYNFGDVTAGVIG 538
L +R+ ++ H ++ AL + V +F + E LRIG + G V AGV+G
Sbjct: 958 L--PIRNGAQ----HADEIATMALHLLSVTTHFQIGHMPEERLKLRIGLHTGPVVAGVVG 1011
Query: 539 TTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR--YEFEPRGSVYVKGKDDM 596
T Y ++GD VN+ASRM+S+ +P RI V ++ L A Y + RG++ VKGK +
Sbjct: 1012 ITMPRYCLFGDTVNMASRMESSSLPLRIHVSQSTAGALLAAGGYHLQKRGTISVKGKGEQ 1071
Query: 597 NVYLLVGK 604
+ L GK
Sbjct: 1072 TTFWLKGK 1079
>UniRef50_Q8IT60 Cluster: Guanylate cyclase; n=3; Coelomata|Rep:
Guanylate cyclase - Manduca sexta (Tobacco hawkmoth)
(Tobacco hornworm)
Length = 1258
Score = 110 bits (264), Expect = 1e-22
Identities = 80/247 (32%), Positives = 122/247 (49%), Gaps = 19/247 (7%)
Query: 366 LSFYSNVVANRDKQRVQNM---RNQADWLLHNIIPRHVADQLKNTAKYS-ENHKDVAIIF 421
L YSN + K+R + + + + + LL+ ++PR VA++L ++ E ++V+I F
Sbjct: 860 LEKYSNNLEELIKERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYF 919
Query: 422 ASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLN 481
+ I+ F + S + + +LN+L FD +E+ V K++TIG +M GL
Sbjct: 920 SDIVGFTALAARS--TPVQVVDLLNDLYTTFDAAIEQ---YRVYKVETIGDAYMVVGGLP 974
Query: 482 PDLRHASRGTYDHLYQLMDFALEMQKVVDNFN-HDLFEFDFILRIGYNFGDVTAGVIGTT 540
R DH + AL + + F L + LRIG + G AGV+G T
Sbjct: 975 KRAR-------DHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHSGPCCAGVVGLT 1027
Query: 541 KLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR--YEFEPRGSVYVKGKDDMNV 598
Y ++GD VN ASRM+STG RIQ A L A Y RG +KGK M+
Sbjct: 1028 MPRYCLFGDTVNTASRMESTGAAWRIQTSAATAEKLLAAGGYRLRSRGLTQIKGKGAMHT 1087
Query: 599 YLLVGKK 605
Y L+GK+
Sbjct: 1088 YWLLGKE 1094
>UniRef50_A2DJ96 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=3; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1593
Score = 109 bits (263), Expect = 2e-22
Identities = 73/229 (31%), Positives = 122/229 (53%), Gaps = 16/229 (6%)
Query: 378 KQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHK--DVAIIFASIINFNEMYDESY 435
++ + + Q++ LL I+PR + +L N+ + N IIF I+ F+ +
Sbjct: 1349 RKSAEQAKAQSEKLLFQILPRDIVTRL-NSGETDINFTVPSATIIFIDIVKFSNY--AAT 1405
Query: 436 LKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL-NPDLRHASRGTYDH 494
L + + L+ + A FD L+ + + + KIK IG +MAA+GL D+ H
Sbjct: 1406 LSPAQIMDHLSIIFAKFDTLVAK--YNLITKIKLIGDVYMAAAGLFGTDIAPEK-----H 1458
Query: 495 LYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF-GDVTAGVIGTTKLYYDIWGDAVNI 553
Q+++FALE +D N+ +F + + RIG N G + AGV+GT K +DI GD +N+
Sbjct: 1459 ASQMVNFALESLTALDEANN-MFNSNLMTRIGINTNGPLIAGVLGTDKPVFDIIGDPINV 1517
Query: 554 ASRMDSTGVPQRIQVGEACVP-VLSARYEFEPRGSVYVKGKDDMNVYLL 601
ASR+ STG+P +Q+ E +++ Y E RG + +KGK Y++
Sbjct: 1518 ASRLQSTGIPGTVQISEETYKLIVNMNYNIERRGEIELKGKGKKMAYIV 1566
>UniRef50_A1ZVN3 Cluster: Adenylate or guanylate cyclase; n=1;
Microscilla marina ATCC 23134|Rep: Adenylate or
guanylate cyclase - Microscilla marina ATCC 23134
Length = 774
Score = 109 bits (262), Expect = 2e-22
Identities = 67/231 (29%), Positives = 120/231 (51%), Gaps = 12/231 (5%)
Query: 372 VVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENH-KDVAIIFASIINFNEM 430
+ A RD V+ +N++D LL NI+P A +LK + H V+++F F ++
Sbjct: 551 IEAQRDAIEVE--KNKSDRLLLNILPYATAQELKEKGNATPQHYPKVSVLFTDFKGFTKL 608
Query: 431 YDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRG 490
++ L E + LN + FD++ ++ ++EKIKTIG +MAA G+
Sbjct: 609 AEK--LTPTEVIAELNYCFSAFDDICQK---YNIEKIKTIGDAYMAAGGIPVANDTNPID 663
Query: 491 TYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDA 550
T ++ F + + + ++E LR+G + G+V AGV+G K YD+WGD
Sbjct: 664 TIKAGLEMQTFMAQWKTNKEAQGLPVWE----LRLGIHTGEVVAGVVGKNKFAYDVWGDT 719
Query: 551 VNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLL 601
VN+A+RM+S+G P + + ++ ++E RG + K K ++++Y +
Sbjct: 720 VNLAARMESSGAPGMVNISGHTYQLIKDQFETTYRGKIKAKNKGEVDMYFV 770
>UniRef50_Q6UCJ4 Cluster: Guanylate cyclase PcGC-M2 precursor; n=5;
Pleocyemata|Rep: Guanylate cyclase PcGC-M2 precursor -
Procambarus clarkii (Red swamp crayfish)
Length = 1423
Score = 109 bits (262), Expect = 2e-22
Identities = 86/242 (35%), Positives = 119/242 (49%), Gaps = 23/242 (9%)
Query: 372 VVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-KNTAKYSENHKDVAIIFASIINFNEM 430
+V NR +Q R D LLH ++P VA L + A + V I F+ I+ F +
Sbjct: 951 LVTNRTQQLRDEQRKTKD-LLHRMLPSSVAASLTQGIAVEPQGFDSVTIYFSDIVGFTSL 1009
Query: 431 YDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL-NPDL-RHAS 488
ES + +R LN+L FD ++ V K++TIG +M SGL P++ RHA
Sbjct: 1010 SAES--TPYQVVRFLNDLYTLFDNIIRG---YDVYKVETIGDAYMVVSGLPKPNMGRHAG 1064
Query: 489 RGTYDHLYQLMDFALEMQKVVDN---FNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYD 545
++ ALE+ V N H E +LRIG + G V AGV+G T Y
Sbjct: 1065 --------EIASMALELLDGVQNKFIIRHRP-EKKLLLRIGLHTGPVIAGVVGLTMPRYC 1115
Query: 546 IWGDAVNIASRMDSTGVPQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDMNVYLLVG 603
++GD VN ASRM+S G P RI + E C L Y EPRG V +KGK ++ + L
Sbjct: 1116 LFGDTVNTASRMESNGEPLRIHISEQCHIALKNLGGYVMEPRGLVTMKGKGEVLTFWLNS 1175
Query: 604 KK 605
K
Sbjct: 1176 AK 1177
>UniRef50_P51841 Cluster: Retinal guanylyl cyclase 2 precursor; n=48;
Euteleostomi|Rep: Retinal guanylyl cyclase 2 precursor -
Homo sapiens (Human)
Length = 1108
Score = 109 bits (261), Expect = 3e-22
Identities = 82/248 (33%), Positives = 128/248 (51%), Gaps = 19/248 (7%)
Query: 366 LSFYSNVVANRDKQRVQNM---RNQADWLLHNIIPRHVADQLKNTAKYSENHKD-VAIIF 421
L YS+ + + ++R + + + + + LL ++P VA+ LK D V + F
Sbjct: 828 LEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYF 887
Query: 422 ASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLN 481
+ I+ F + S + E + +LN+L FD ++ V K++TIG +M ASGL
Sbjct: 888 SDIVGFTTISAMS--EPIEVVDLLNDLYTLFDAIIGS---HDVYKVETIGDAYMVASGLP 942
Query: 482 PDLRHASRGTYDHLYQLMDFALEMQKVVDNFN-HDLFEFDFILRIGYNFGDVTAGVIGTT 540
R+ SR H ++ + +L++ V F + E +RIG + G V AGV+G T
Sbjct: 943 K--RNGSR----HAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLT 996
Query: 541 KLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPV---LSARYEFEPRGSVYVKGKDDMN 597
Y ++GD VN ASRM+STG+P RI V + V + LS YE E RG +KGK
Sbjct: 997 MPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEE 1056
Query: 598 VYLLVGKK 605
+ L+GKK
Sbjct: 1057 TFWLIGKK 1064
>UniRef50_A1ZXW2 Cluster: Adenylate cyclase; n=1; Microscilla marina
ATCC 23134|Rep: Adenylate cyclase - Microscilla marina
ATCC 23134
Length = 362
Score = 108 bits (260), Expect = 4e-22
Identities = 71/234 (30%), Positives = 125/234 (53%), Gaps = 16/234 (6%)
Query: 376 RDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHKDVA-IIFASIINFNEMYDES 434
R ++ + Q++ LL NI+P+ +A++LK + ++A ++F F + +
Sbjct: 119 RSAIQLSHAYKQSEELLLNILPKEIAEELKAKGTVAPKPYELATVLFTDFKGFTSV--AA 176
Query: 435 YLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDH 494
+K + L+ LN FDE++E+ + +E+IKTIG +M G+ + T +
Sbjct: 177 RMKPIDLLKELNACFDAFDEIIEKHE---MERIKTIGDAYMCVGGV------PNANTTNP 227
Query: 495 LYQLMDFALEMQKVVDNFNHDLF---EFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAV 551
+ ++ ALEMQ+ + + E + R+G N G+V AGVIG K YDIWGD V
Sbjct: 228 VNAVLA-ALEMQRFMKQKREEKASQGENYWQCRLGINSGEVIAGVIGRKKFAYDIWGDTV 286
Query: 552 NIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLLVGKK 605
N ASRM+S G ++ + + ++ +E E RG + KGK ++++Y ++G K
Sbjct: 287 NSASRMESNGEAGKVNISGSTHALVKDLFECEHRGKINAKGKGEVDMYFVLGIK 340
>UniRef50_A7RZH8 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 622
Score = 108 bits (260), Expect = 4e-22
Identities = 76/230 (33%), Positives = 119/230 (51%), Gaps = 17/230 (7%)
Query: 379 QRVQNMRNQADWLLHNIIPRHVADQLKN---TAKYSENHKDVAIIFASIINFNEMYDESY 435
+ + N + + D LL+ +IP+ VAD+L+ E +V I+F+ ++ F + S
Sbjct: 405 RELDNEKLRTDALLYQMIPKTVADRLRKGEPALNTCETFSNVTILFSDVVGFTTIC--SL 462
Query: 436 LKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHL 495
+ + + +LN + FD+L E+ +V K++TIG +M SG+ P+ R Y H
Sbjct: 463 IAPMQVVTMLNCMYTTFDKLSEK---HNVYKVETIGDAYMVVSGI-PE-----RTKY-HA 512
Query: 496 YQLMDFALEMQKVVDNFNHDLFEFDFI-LRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIA 554
+ D AL M + D + +RIG + G V AGV+G Y ++GD VN A
Sbjct: 513 EHVADMALNMLSAMPEIEDPAGLNDHLRIRIGIHTGTVVAGVVGLKMPRYCLFGDTVNTA 572
Query: 555 SRMDSTGVPQRIQVGEACVPVLS-ARYEFEPRGSVYVKGKDDMNVYLLVG 603
SRM+STG+ I V E L+ A Y + RGS+ +KGK M Y L+G
Sbjct: 573 SRMESTGLAMAIHVSEDTQKFLAKANYALKQRGSMDIKGKGGMKTYWLLG 622
>UniRef50_Q23310 Cluster: Guanylate cyclase; n=1; Caenorhabditis
elegans|Rep: Guanylate cyclase - Caenorhabditis elegans
Length = 1170
Score = 108 bits (259), Expect = 5e-22
Identities = 76/238 (31%), Positives = 124/238 (52%), Gaps = 17/238 (7%)
Query: 373 VANRDKQRVQNMRNQADWLLHNIIPRHVADQLK-NTAKYSENHKDVAIIFASIINFNEMY 431
V++R K+ V+ + ++D LL+ ++P+ VAD+LK E + V I F+ ++ F +
Sbjct: 889 VSDRTKELVEE-KKKSDVLLYRMLPKMVADKLKLGQTVEPETFEQVTIFFSDVVQFTTLA 947
Query: 432 DESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGT 491
+ + + +LN+L FD ++E+ V K++TIG ++ SGL R
Sbjct: 948 GKC--TPLQVVTLLNDLYTIFDGIIEQ---NDVYKVETIGDGYLCVSGL------PHRNG 996
Query: 492 YDHLYQLMDFALEMQKVVDNFNHDLFEFDFI-LRIGYNFGDVTAGVIGTTKLYYDIWGDA 550
+H+ + +L ++ F + I LRIG N G V AGV+G T Y ++GDA
Sbjct: 997 NEHIRHIARMSLGFLSSLEFFRVQHLPSERINLRIGINCGSVVAGVVGLTMPRYCLFGDA 1056
Query: 551 VNIASRMDSTGVPQRIQVGEACVPVLS---ARYEFEPRGSVYVKGKDDMNVYLLVGKK 605
VN ASRM+S G P +I V +L+ + E RG V +KGK M Y L+G++
Sbjct: 1057 VNTASRMESNGKPGKIHVTAEANQMLTQVVGGFRTESRGEVIIKGKGVMETYWLLGEQ 1114
>UniRef50_A2GA06 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1568
Score = 107 bits (257), Expect = 8e-22
Identities = 80/345 (23%), Positives = 159/345 (46%), Gaps = 14/345 (4%)
Query: 262 NWLAKNTLVTLYAGVFLFVTFLGCHEVNTQYLDGDIKLYP-QFLAQNLTDYFYPNDNTSD 320
NW +V + + +G E+ ++ ++ + P Q L QN++++ D
Sbjct: 1212 NWSISKGIVMSASECVIVTNTMGVIEIVNPAVNTNLGMTPDQMLGQNISNFAVSGDKNKI 1271
Query: 321 RSENNN-TLNYEGMHHKXXXXXXXXXXXXXXXXXXXXNREFEISYRLSFYSNVVANRDKQ 379
S ++ + + + E E+S+ + + + ++
Sbjct: 1272 NSLFSSLSESQNSAQDQNHFINDSSRSIPFNVSRFLVKEEKEVSFVFIMTNILDETKKRK 1331
Query: 380 RVQNMRNQADWLLHNIIPRHVADQLKNTAK-YSENHKDVAIIFASIINFNEMYDESYLKG 438
+ + +++ LL+ I+P+ + +L K S N ++ F I+ F++ S+L
Sbjct: 1332 AAETAKAKSEKLLYQILPKDIVLRLNRGEKDISFNINHSSVFFIDIVKFSQY--SSHLSP 1389
Query: 439 KEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQL 498
E ++ L+ + +FD+++ QF V KIK IG +MAASG+ H +H
Sbjct: 1390 SEIMQNLSLVFNNFDKIVV--QFPLVNKIKLIGDVYMAASGIF----HQDNSKEEHAESA 1443
Query: 499 MDFALEMQKVVDNFNHDLFEFDFILRIGYNFGD-VTAGVIGTTKLYYDIWGDAVNIASRM 557
+ L+ K +++ N L LRIG N G + GV+G K +DI GD +N+A+R+
Sbjct: 1444 VKCCLKCLKSMEDINTKL-NSSLELRIGINSGGPLIGGVLGADKPTFDIIGDPINVAARL 1502
Query: 558 DSTGVPQRIQVGEACVPVLSAR-YEFEPRGSVYVKGKDDMNVYLL 601
S+ +P R+Q+ ++ ++ + + E RG V++KGK + Y +
Sbjct: 1503 QSSDIPGRVQISQSIKELIKSNDFTIEERGEVFLKGKGNQITYFI 1547
>UniRef50_UPI00015B6146 Cluster: PREDICTED: similar to
ENSANGP00000009149; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000009149 - Nasonia
vitripennis
Length = 1329
Score = 107 bits (256), Expect = 1e-21
Identities = 76/225 (33%), Positives = 112/225 (49%), Gaps = 15/225 (6%)
Query: 385 RNQADWLLHNIIPRHVADQLKNTAKY-SENHKDVAIIFASIINFNEMYDESYLKGKEYLR 443
+ + D LL+ ++PR+VA+QLK K +EN V I F+ I+ F M ES + +
Sbjct: 866 KKKTDALLYEMLPRYVAEQLKRGHKVEAENFDCVTIYFSDIVGFTAMSAES--TPLQVVD 923
Query: 444 ILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFAL 503
LN+L FD +E V K++TIG +M SGL R H ++ +L
Sbjct: 924 FLNDLYTCFDSTIEN---YDVYKVETIGDAYMVVSGL------PIRNGIQHAGEIASMSL 974
Query: 504 EMQKVVDNFNHDLFEFDFI-LRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGV 562
+ + F+ D + LRIG + G V AGV+G Y ++GD VN ASRM+STG
Sbjct: 975 HLLDAIKQFSIRHRPLDKLQLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGS 1034
Query: 563 PQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDMNVYLLVGKK 605
P RI +L + RG V +KGK + Y L+G++
Sbjct: 1035 PLRIHCSTETKQLLDQLGGFSLAERGLVSMKGKGERLTYWLIGEE 1079
>UniRef50_Q9XTY1 Cluster: Guanylate cyclase; n=2;
Caenorhabditis|Rep: Guanylate cyclase - Caenorhabditis
elegans
Length = 1012
Score = 107 bits (256), Expect = 1e-21
Identities = 67/223 (30%), Positives = 116/223 (52%), Gaps = 16/223 (7%)
Query: 385 RNQADWLLHNIIPRHVADQLK-NTAKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLR 443
+ ++D LL+ ++P+ VA++LK + E V I F+ +++F + S + +
Sbjct: 787 KKRSDVLLYRMLPKQVAEKLKLGQSVEPETFDCVTIFFSDVVSFTTL--ASRCTPLQVVN 844
Query: 444 ILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFAL 503
+LN+L FD ++E+ V K++TIG ++ SGL R +H ++ +
Sbjct: 845 LLNDLYTTFDAIIEQ---HDVYKVETIGDGYLCVSGL------PHRNGNEHAKEISSMSF 895
Query: 504 EMQKVVDNFNHDLFEFDFI-LRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGV 562
+ K + F + I +R+G + G V GV+G T Y ++GD+VN ASRM+S G
Sbjct: 896 SLLKAIKTFRVPHLPKERINIRVGLHTGPVVTGVVGMTMPRYCLFGDSVNTASRMESNGK 955
Query: 563 PQRIQVGEACVPVLS---ARYEFEPRGSVYVKGKDDMNVYLLV 602
P R+ + C+ L+ Y+ EPRG V VKGK + + L+
Sbjct: 956 PGRVHISTECMKFLTEVIGGYQTEPRGEVIVKGKGAVQTHWLL 998
>UniRef50_Q7JP51 Cluster: Guanylate cyclase; n=6; Caenorhabditis|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1111
Score = 107 bits (256), Expect = 1e-21
Identities = 76/236 (32%), Positives = 121/236 (51%), Gaps = 16/236 (6%)
Query: 373 VANRDKQRVQNMRNQADWLLHNIIPRHVADQLK-NTAKYSENHKDVAIIFASIINFNEMY 431
V+ R K+ V+ + ++D LL+ ++P+ VAD+LK E + V I F+ ++ F +
Sbjct: 851 VSERTKELVEE-KKKSDVLLYRMLPKTVADKLKLGQTVEPETFEQVTIFFSDVVQFTTL- 908
Query: 432 DESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGT 491
S + + +LN+L FD ++E+ V K++TIG ++ SGL R
Sbjct: 909 -ASKCTPLQVVNLLNDLYTIFDGIIEK---HDVYKVETIGDGYLCVSGL------PHRNG 958
Query: 492 YDHLYQLMDFALEMQKVVDNFNHDLFEFDFI-LRIGYNFGDVTAGVIGTTKLYYDIWGDA 550
+H+ Q+ +L + F + I LRIG N G V AGV+G T + ++GDA
Sbjct: 959 NEHVRQIALMSLAFLSSLQFFRVPHLPSERINLRIGMNCGSVVAGVVGLTMPRFCLFGDA 1018
Query: 551 VNIASRMDSTGVPQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDMNVYLLVGK 604
VN ASRM+S G P +I V +L ++ E RG V +KGK M + L G+
Sbjct: 1019 VNTASRMESNGKPGKIHVSAEANRMLHLVGGFDTESRGEVIIKGKGVMETFWLTGQ 1074
>UniRef50_Q09435 Cluster: Guanylate cyclase receptor-type gcy-1
precursor; n=5; Caenorhabditis|Rep: Guanylate cyclase
receptor-type gcy-1 precursor - Caenorhabditis elegans
Length = 1137
Score = 107 bits (256), Expect = 1e-21
Identities = 74/249 (29%), Positives = 129/249 (51%), Gaps = 22/249 (8%)
Query: 366 LSFYSNVVANRDKQRVQNM---RNQADWLLHNIIPRHVADQLK-NTAKYSENHKDVAIIF 421
L Y++ + ++R + + + +AD LL ++P+ VA++LK E V + F
Sbjct: 842 LEEYTSTLEEEIEERTKELTLEKKKADILLSRMLPKQVAERLKAGQTVEPEGFDSVTVFF 901
Query: 422 ASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQH-VEKIKTIGSTFMAASGL 480
+ ++ F + S + + +LN+L ++FD ++E QH V K+++IG ++ SGL
Sbjct: 902 SDVVKFTIL--ASKCSPFQTVNLLNDLYSNFDTIIE----QHGVYKVESIGDGYLCVSGL 955
Query: 481 NPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFI-LRIGYNFGDVTAGVIGT 539
+R Y H+ Q++D +L+ + +FN + + LRIG N G AGV+G
Sbjct: 956 ------PTRNGYAHIKQIVDMSLKFMEYCKSFNIPHLPRENVELRIGVNSGPCVAGVVGL 1009
Query: 540 TKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSA----RYEFEPRGSVYVKGKDD 595
+ Y ++GD VN ASRM+S G P I + +L+ +YE RG V +KGK
Sbjct: 1010 SMPRYCLFGDTVNTASRMESNGKPSLIHLTNDAHSLLTTHYPNQYETSSRGEVIIKGKGV 1069
Query: 596 MNVYLLVGK 604
M + + G+
Sbjct: 1070 METFWVHGR 1078
>UniRef50_A2DXM9 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 696
Score = 106 bits (255), Expect = 1e-21
Identities = 68/230 (29%), Positives = 123/230 (53%), Gaps = 14/230 (6%)
Query: 376 RDKQRVQNMRNQADWLLHNIIPRHVADQLK-NTAKYSENHKDVAIIFASIINFNEMYDES 434
R ++V+ + A+ LL+ I+P + ++ + S IIF I F++ +
Sbjct: 448 RQMRQVEEAKKSAERLLNQILPPMIVQKMNAGETEISFTVNSATIIFIDIQKFSDY--AA 505
Query: 435 YLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL-NPDLRHASRGTYD 493
L ++ ++ L + +DEL+ P+F + KIK IG +MAA+GL NPD+ T
Sbjct: 506 TLTARQIMQNLGRIFNYYDELV--PKFPTLIKIKLIGDVYMAAAGLFNPDVSPDVHAT-- 561
Query: 494 HLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGD-VTAGVIGTTKLYYDIWGDAVN 552
++++FA+ ++ N ++ E +RIG N G + AGV+G K +DI GD +N
Sbjct: 562 ---EMINFAIGCLHGLEEAN-EILEASLSVRIGINTGGPIIAGVLGIDKPLFDIIGDPIN 617
Query: 553 IASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSVYVKGKDDMNVYLL 601
+ASR+ ST +P IQ+ +A ++ + + RG +++KGK + Y++
Sbjct: 618 VASRLQSTDIPNMIQISQATYDLIKDKGFNVAERGKIFLKGKGEQMAYII 667
>UniRef50_Q02846 Cluster: Retinal guanylyl cyclase 1 precursor; n=23;
Eukaryota|Rep: Retinal guanylyl cyclase 1 precursor -
Homo sapiens (Human)
Length = 1103
Score = 106 bits (255), Expect = 1e-21
Identities = 81/248 (32%), Positives = 130/248 (52%), Gaps = 19/248 (7%)
Query: 366 LSFYSNVVANRDKQRVQNM---RNQADWLLHNIIPRHVADQLKN-TAKYSENHKDVAIIF 421
L YS+ + + ++R + + + + D LL ++P VA+ LK T E + V + F
Sbjct: 824 LEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYF 883
Query: 422 ASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLN 481
+ I+ F + S + E + +LN+L FD ++ V K++TIG +M ASGL
Sbjct: 884 SDIVGFTTISAMS--EPIEVVDLLNDLYTLFDAIIGS---HDVYKVETIGDAYMVASGL- 937
Query: 482 PDLRHASRGTYDHLYQLMDFALEMQKVVDNFN-HDLFEFDFILRIGYNFGDVTAGVIGTT 540
P R+ R H ++ + +L++ V F + E +RIG + G AGV+G T
Sbjct: 938 PQ-RNGQR----HAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLT 992
Query: 541 KLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSA---RYEFEPRGSVYVKGKDDMN 597
Y ++GD VN ASRM+STG+P RI V + V +L A Y+ E RG +KGK +
Sbjct: 993 MPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAED 1052
Query: 598 VYLLVGKK 605
+ LVG++
Sbjct: 1053 TFWLVGRR 1060
>UniRef50_P16065 Cluster: Speract receptor precursor; n=7;
Euechinoidea|Rep: Speract receptor precursor -
Strongylocentrotus purpuratus (Purple sea urchin)
Length = 1125
Score = 106 bits (255), Expect = 1e-21
Identities = 78/230 (33%), Positives = 117/230 (50%), Gaps = 15/230 (6%)
Query: 379 QRVQNMRNQADWLLHNIIPRHVADQL-KNTAKYSENHKDVAIIFASIINFNEMYDESYLK 437
Q +Q + + + LLH ++P +A QL K A E + V+I F+ I+ F + S
Sbjct: 874 QELQKEKTKTEQLLHRMLPPSIASQLIKGIAVLPETFEMVSIFFSDIVGFTALSAAS--T 931
Query: 438 GKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQ 497
+ + +LN+L FD ++ V K++TIG +M SGL LR+ R H Q
Sbjct: 932 PIQVVNLLNDLYTLFDAIISN---YDVYKVETIGDAYMLVSGL--PLRNGDR----HAGQ 982
Query: 498 LMDFALEMQKVVDNFNHDLFEFDFI-LRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASR 556
+ A + + V F F+ LRIG + G AGV+G T Y ++GD VN ASR
Sbjct: 983 IASTAHHLLESVKGFIVPHKPEVFLKLRIGIHSGSCVAGVVGLTMPRYCLFGDTVNTASR 1042
Query: 557 MDSTGVPQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDMNVYLLVGK 604
M+S G+ RI V C VL YE E RG V + GK +++ + L+G+
Sbjct: 1043 MESNGLALRIHVSPWCKQVLDKLGGYELEDRGLVPMNGKGEIHTFWLLGQ 1092
>UniRef50_A2BFQ0 Cluster: Guanylate cyclase; n=3; Danio rerio|Rep:
Guanylate cyclase - Danio rerio (Zebrafish) (Brachydanio
rerio)
Length = 1176
Score = 106 bits (254), Expect = 2e-21
Identities = 76/247 (30%), Positives = 131/247 (53%), Gaps = 19/247 (7%)
Query: 366 LSFYSNVVANRDKQRVQNM---RNQADWLLHNIIPRHVADQLKNTAKYSENH-KDVAIIF 421
L YS+ + + ++R + + R + D LL ++P+ VA LK H +V + F
Sbjct: 897 LEQYSSNLEDLIRERTEELEVERQKTDALLAQMLPKSVALALKTGKPVKPEHFAEVTLYF 956
Query: 422 ASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLN 481
+ I+ F + + + E + +LN+L FD ++ V K++TIG +M ASG+
Sbjct: 957 SDIVGFTTI--SALSEPIEVVDLLNDLYTHFDGIIA---IHDVYKVETIGDAYMVASGV- 1010
Query: 482 PDLRHASRGTYDHLYQLMDFALEMQKVVDNFN-HDLFEFDFILRIGYNFGDVTAGVIGTT 540
P+ R+ +R H ++ + +L++ + F + + +RIG + G V AGV+G
Sbjct: 1011 PN-RNGTR----HAAEMANMSLDILHCIGTFKMRHMPDVKVKIRIGLHSGPVVAGVVGLK 1065
Query: 541 KLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSA---RYEFEPRGSVYVKGKDDMN 597
Y ++GD VN ASRM+STG+P RI V ++ V VL++ Y+ + RG +KGK
Sbjct: 1066 MPRYCLFGDTVNTASRMESTGLPYRIHVNQSTVDVLNSLKLGYKIDTRGRTELKGKGVEE 1125
Query: 598 VYLLVGK 604
+ LVG+
Sbjct: 1126 TFWLVGR 1132
>UniRef50_A6PTF8 Cluster: Putative adenylate/guanylate cyclase; n=1;
Victivallis vadensis ATCC BAA-548|Rep: Putative
adenylate/guanylate cyclase - Victivallis vadensis ATCC
BAA-548
Length = 281
Score = 106 bits (254), Expect = 2e-21
Identities = 71/225 (31%), Positives = 111/225 (49%), Gaps = 14/225 (6%)
Query: 378 KQRVQNMRNQADWLLHNIIPRHVADQLKNT-AKYSENHKDVAIIFASIINFNEMYDESYL 436
K+ ++ R +++ LL NI+P V L+ A E +V + F+ I+ F M E L
Sbjct: 68 KESLEQERERSEQLLRNILPERVIRVLQREGASKPELFDNVTVFFSDIVGFTRMSAE--L 125
Query: 437 KGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLY 496
+ + L+++ FD + E+IKTIG ++A GL P+ R +H
Sbjct: 126 TPEAVIAELSDIFTQFDHIFTS---HGCERIKTIGDAYLAVCGL-PEPRP------EHCA 175
Query: 497 QLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASR 556
++ ALE + ++ N D + +R G + G V G++GT K YDI+GD VN A+R
Sbjct: 176 NILRSALEARAYLERRNQDS-PHQWRMRFGIHSGSVVGGIVGTEKYLYDIFGDTVNTAAR 234
Query: 557 MDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLL 601
M+ P RI V E + A F PR VKGK +M ++ L
Sbjct: 235 MEQLSEPMRINVSETVRNLAPADCVFTPRPPQEVKGKGEMKMFFL 279
>UniRef50_A1ZJP1 Cluster: Adenylate cyclase; n=1; Microscilla marina
ATCC 23134|Rep: Adenylate cyclase - Microscilla marina
ATCC 23134
Length = 642
Score = 105 bits (252), Expect = 3e-21
Identities = 68/227 (29%), Positives = 118/227 (51%), Gaps = 16/227 (7%)
Query: 379 QRVQNMRNQADWLLHNIIPRHVADQLKNTAKYS-ENHKDVAIIFASIINFNEMYDESYLK 437
+ ++ + +D LL NI+P VA++LK K +H+ V+++F F ++ + +
Sbjct: 389 ETIKQEQQISDALLLNILPEQVANELKEHGKAKIRHHEMVSVLFTDFKGFTKLAET--MP 446
Query: 438 GKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQ 497
+E ++ L + FDE++E+ ++EKIKTIG +MA GL +
Sbjct: 447 PQELVQELEKCFTLFDEIMEK---HNLEKIKTIGDAYMAVGGLPVP-------NTTNFVD 496
Query: 498 LMDFALEMQKVVDNFNHDLF---EFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIA 554
++ LE+Q+ +D + E + R+G N G + AGVIG K YD+WGD VN A
Sbjct: 497 IVLAGLEIQRSMDQLKAEKEAKGEPFWETRLGINTGKLIAGVIGKNKFAYDVWGDTVNTA 556
Query: 555 SRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLL 601
SRM+S+G R+ + ++ +E E RG + K K +++Y +
Sbjct: 557 SRMESSGEIGRVNISGVTYELVKDFFECEYRGKIMAKNKGAIDMYFV 603
>UniRef50_O96993 Cluster: Guanylate cyclase; n=1; Heterodera
glycines|Rep: Guanylate cyclase - Heterodera glycines
(Soybean cyst nematode worm)
Length = 1151
Score = 105 bits (252), Expect = 3e-21
Identities = 70/237 (29%), Positives = 122/237 (51%), Gaps = 17/237 (7%)
Query: 373 VANRDKQRVQNMRNQADWLLHNIIPRHVADQLK-NTAKYSENHKDVAIIFASIINFNEMY 431
V R K+ V+ R ++D LL+ ++PR VAD+LK + E+ + I F+ +++F +
Sbjct: 906 VEERTKELVEEKR-KSDILLYRMLPRQVADKLKIGESVEPESFQMATIFFSDVVSFTTLA 964
Query: 432 DESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGT 491
+ + + +LN L FD +++ K++TIG ++ SG+ R
Sbjct: 965 GKC--SPLQVVNLLNGLFTAFDGIIDT---HDCYKVETIGDGYLVCSGI------PKRNG 1013
Query: 492 YDHLYQLMDFALEMQKVVDNFNHDLFEFDFI-LRIGYNFGDVTAGVIGTTKLYYDIWGDA 550
H ++ + + + V +F D + + LRIG++ G AGV+G T Y ++GD+
Sbjct: 1014 DQHAKEIAELSFAFLRTVSSFRVDHLPSERVNLRIGFHSGPAVAGVVGLTMPRYCLFGDS 1073
Query: 551 VNIASRMDSTGVPQRIQVGEACVPVLSA---RYEFEPRGSVYVKGKDDMNVYLLVGK 604
VN ASRM+S G R+ + + L++ Y EPRG V +KGK M + L+G+
Sbjct: 1074 VNTASRMESNGKAGRVHISSSANHFLTSVIGGYVTEPRGEVIIKGKGVMETFWLLGR 1130
>UniRef50_A2EQT4 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1579
Score = 105 bits (251), Expect = 5e-21
Identities = 72/229 (31%), Positives = 123/229 (53%), Gaps = 12/229 (5%)
Query: 376 RDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK-YSENHKDVAIIFASIINFNEMYDES 434
+ + ++ + +++ LL I+P+ + +L K S +IIF I+ F+E Y S
Sbjct: 1340 KQMKEAEDAKQKSETLLFQILPKDIVVRLGRGEKDISFTVPSASIIFIDIVKFSE-YAAS 1398
Query: 435 YLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDH 494
L +E + L+ + A FDE++++ + + KIK IG +MAA+GL + + H
Sbjct: 1399 -LTPQEIMGNLSTVFAAFDEMVKK--YPKITKIKLIGDVYMAAAGLFDEQDDPA----SH 1451
Query: 495 LYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGD-VTAGVIGTTKLYYDIWGDAVNI 553
+++F L+ +D N L +RIG N G + AGV+GT K +DI GD +NI
Sbjct: 1452 AKDMVNFGLDCLGELDEVNVKL-NASLEVRIGINTGGPLLAGVLGTDKPVFDIIGDPINI 1510
Query: 554 ASRMDSTGVPQRIQVGEACVPVL-SARYEFEPRGSVYVKGKDDMNVYLL 601
A+R+ ST + RIQ+ +A + ++ + E RG V++KGK YL+
Sbjct: 1511 AARLQSTDIAGRIQISKATKEYIENSNFNIEERGEVFLKGKGKQMTYLV 1559
>UniRef50_Q6PG12 Cluster: Adcy3 protein; n=13; Euteleostomi|Rep:
Adcy3 protein - Mus musculus (Mouse)
Length = 1005
Score = 104 bits (249), Expect = 8e-21
Identities = 55/135 (40%), Positives = 83/135 (61%), Gaps = 7/135 (5%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK-----YS 411
+R E R F + + K+RV MR + L+ N++P HVA + K YS
Sbjct: 858 SRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYS 917
Query: 412 ENHKDVAIIFASIINFNEMYDESYLK--GKEYLRILNELIADFDELLERPQFQHVEKIKT 469
+++ ++ ++FAS+ NF + Y E + G E LR LNE+I+DFD LL+ P+F+ + KIKT
Sbjct: 918 QSYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKT 977
Query: 470 IGSTFMAASGLNPDL 484
IGST+MAASG+ PD+
Sbjct: 978 IGSTYMAASGVTPDV 992
Score = 96.3 bits (229), Expect = 2e-18
Identities = 61/221 (27%), Positives = 111/221 (50%), Gaps = 27/221 (12%)
Query: 378 KQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHKD--------------VAIIFAS 423
K ++ Q + L+ +I+P+HVAD++ K E+ KD V+I+FA
Sbjct: 265 KMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFAD 324
Query: 424 IINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPD 483
I+ F ++ S +E +++LNEL A FD+L + H +IK +G + GL PD
Sbjct: 325 IVGFTQL--SSACSAQELVKLLNELFARFDKLAAK---YHQLRIKILGDCYYCICGL-PD 378
Query: 484 LRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLY 543
R DH + L M + + ++ + + +R+G + G V GV+G +
Sbjct: 379 YRE------DHAVCSILMGLAMVEAI-SYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQ 431
Query: 544 YDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP 584
YD+W V +A++M++ G+P R+ + ++ + L ++ EP
Sbjct: 432 YDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEP 472
>UniRef50_Q03101 Cluster: Adenylate cyclase, germination specific;
n=3; Dictyostelium discoideum|Rep: Adenylate cyclase,
germination specific - Dictyostelium discoideum (Slime
mold)
Length = 858
Score = 104 bits (249), Expect = 8e-21
Identities = 69/243 (28%), Positives = 124/243 (51%), Gaps = 20/243 (8%)
Query: 371 NVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKY-SENHKDVAIIFASIINFNE 429
+V + K + + + + L++ I+P V+ +L+N +E + + F I F
Sbjct: 348 SVDQRKQKSLIAKIMREKNNLINKILPLEVSVKLENGEDVVAERSNNACVFFLDIAGFTR 407
Query: 430 MYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNP---DLRH 486
S ++ +++L ++ D L + +EKIKTIG +MA G+ P D+RH
Sbjct: 408 F--SSIHSPEQVIQVLIKIFNSMDLLCAK---HGIEKIKTIGDAYMATCGIFPKCDDIRH 462
Query: 487 ASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVI-GTTKLYYD 545
+ Y+++ FA+++ + + F +R+G + G V +GVI G K ++D
Sbjct: 463 -------NTYKMLGFAMDVLEFIPK--EMSFHLGLQVRVGIHCGPVISGVISGYAKPHFD 513
Query: 546 IWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPR-GSVYVKGKDDMNVYLLVGK 604
+WGD VN+ASRM+STG+ +I V + + + F R ++VKGK M + L+GK
Sbjct: 514 VWGDTVNVASRMESTGIAGQIHVSDRVYQLGKEDFNFSERCDIIHVKGKGRMKTWYLMGK 573
Query: 605 KDT 607
K +
Sbjct: 574 KSS 576
>UniRef50_UPI00015B48AF Cluster: PREDICTED: similar to
ENSANGP00000014144; n=2; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000014144 - Nasonia
vitripennis
Length = 1648
Score = 103 bits (248), Expect = 1e-20
Identities = 77/247 (31%), Positives = 127/247 (51%), Gaps = 20/247 (8%)
Query: 365 RLSFYSNVVANRDKQRVQNM---RNQADWLLHNIIPRHVADQLK-NTAKYSENHKDVAII 420
R+ Y+N + +++ + + + +++ LL+ ++PR VA QL E + V I
Sbjct: 1362 RMEQYANNLEALVEEKTEQLSLEKRRSEELLYQVLPRQVACQLMAGEMVQPEQFECVTIY 1421
Query: 421 FASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL 480
F+ I+ F + +S E + LN+L + FD ++ F V K++TIG +M SGL
Sbjct: 1422 FSDIVGFTALCAKS--TPMEVVDFLNDLYSTFDRIIG---FYDVYKVETIGDAYMVVSGL 1476
Query: 481 NPDLRHASRGTYDHLYQLMDFALEMQKVVDNFN--HDLFEFDFILRIGYNFGDVTAGVIG 538
P+ R +H ++ AL + V +F H + +RIG + G V AGV+G
Sbjct: 1477 -PE-----RNGDEHSKEIALMALAILDAVKSFTIIHKQ-DAQLSVRIGVHSGPVCAGVVG 1529
Query: 539 TTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDM 596
+Y ++GD VN ASRM+S+G+P RI V A +L ++ E RG V +KGK +
Sbjct: 1530 QKMPHYCLFGDTVNTASRMESSGLPLRIHVSRATKDILDKYGTFDLELRGDVELKGKGKV 1589
Query: 597 NVYLLVG 603
+ L G
Sbjct: 1590 TTFWLTG 1596
>UniRef50_Q92WJ5 Cluster: Putative regulatory protein; n=2;
Sinorhizobium|Rep: Putative regulatory protein -
Rhizobium meliloti (Sinorhizobium meliloti)
Length = 520
Score = 103 bits (248), Expect = 1e-20
Identities = 70/228 (30%), Positives = 122/228 (53%), Gaps = 15/228 (6%)
Query: 375 NRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKY-SENHKDVAIIFASIINFNEMYDE 433
+R Q+++ + +AD L+ I+P + +L++ + ++ +V+I+FA I+ F+ +
Sbjct: 306 HRYLQQIKTEKLRADSLIRAILPDQIVARLQDGEEIIADRFDEVSILFADIVGFSPI--A 363
Query: 434 SYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYD 493
+ L + +R L+ + FD L E+ VEKIKTIG +MAA G+ P+ D
Sbjct: 364 ASLTASDLVRRLDRMFRRFDLLTEQ---HRVEKIKTIGDAYMAACGI-PE------PAPD 413
Query: 494 HLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNI 553
H +++ M + + + F +RIG + G V AG+IG + YD+WG+ VNI
Sbjct: 414 HADRIVALGKSMLRSLQDMEAGPDRFR--VRIGIHTGPVVAGLIGRLRFVYDVWGETVNI 471
Query: 554 ASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLL 601
ASR++S GV IQ+ EA L + E R ++ ++G + YL+
Sbjct: 472 ASRLESQGVADVIQISEATRRALRGPWTLERRCALELRGIGAVETYLV 519
>UniRef50_A7SPS9 Cluster: Predicted protein; n=11; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 518
Score = 103 bits (248), Expect = 1e-20
Identities = 75/237 (31%), Positives = 117/237 (49%), Gaps = 16/237 (6%)
Query: 371 NVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYS-ENHKDVAIIFASIINFNE 429
++V R Q R + LL+ ++P VA L + + + EN +V+I F+ I+ F
Sbjct: 292 SLVEERTSQLADEKRKTEN-LLNRMLPPSVAKDLVHGKQVTAENFDEVSIFFSDIVGFTS 350
Query: 430 MYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASR 489
+ ES + + +LN+L FDE++ V K++TIG +M SGL R
Sbjct: 351 LSSES--TPLQVVDLLNDLYTLFDEIINN---YDVYKVETIGDAYMVVSGL------PIR 399
Query: 490 GTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFI-LRIGYNFGDVTAGVIGTTKLYYDIWG 548
+ H ++ AL M + +D+F D + LRIG + G AGV+G Y ++G
Sbjct: 400 NGHQHAGEIATMALHMLREIDSFKIRHRPNDKLKLRIGIHSGSCVAGVVGKKMPRYCLFG 459
Query: 549 DAVNIASRMDSTGVPQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDMNVYLLVG 603
D VN ASRM+S G +I + + +L Y + RG V++KGK Y LVG
Sbjct: 460 DTVNTASRMESNGEALKIHISPSTKRILDELGGYHIQKRGKVFLKGKGTWITYWLVG 516
>UniRef50_A2DFE4 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=5; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1681
Score = 103 bits (248), Expect = 1e-20
Identities = 68/231 (29%), Positives = 119/231 (51%), Gaps = 15/231 (6%)
Query: 376 RDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK-YSENHKDVAIIFASIINFNEMYDES 434
R K+ V+ + ++D LL I+P + ++ K + ++IF I F+ +
Sbjct: 1451 RQKEAVEVAKKKSDDLLLKILPPDIIRRINKGEKDITMVVPSASVIFIDICQFSTYM--A 1508
Query: 435 YLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL-NPDLRHASRGTYD 493
L ++ + LN + +D++L + KIK IG +MAA+GL +PD S
Sbjct: 1509 TLSAQQCMSNLNAVFTAYDKILA--DLPLITKIKLIGDDYMAAAGLFSPDEPPKS----- 1561
Query: 494 HLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGD-VTAGVIGTTKLYYDIWGDAVN 552
H Q + F L + ++ N L ++RIG N G + AGV+GT K +DI GD +N
Sbjct: 1562 HAIQTITFGLRVLDAIEELNEQL-NASLMVRIGVNSGGPIIAGVLGTDKPLFDIIGDTIN 1620
Query: 553 IASRMDSTGVPQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDMNVYLL 601
+A+R+ ST +P +Q+ + +++ ++ E RG +Y+KGK + YL+
Sbjct: 1621 VAARLQSTDIPGNVQISKGTYEIVAGEGKFHIEERGEIYLKGKGNQMTYLV 1671
>UniRef50_Q9VEU5 Cluster: Soluble guanylate cyclase 89Db; n=6;
Diptera|Rep: Soluble guanylate cyclase 89Db - Drosophila
melanogaster (Fruit fly)
Length = 669
Score = 103 bits (248), Expect = 1e-20
Identities = 70/220 (31%), Positives = 116/220 (52%), Gaps = 16/220 (7%)
Query: 385 RNQADWLLHNIIPRHVADQLKNTAKY-SENHKDVAIIFASIINFNEMYDESYLKGKEYLR 443
+ Q D LL+++IPR +A++++ + ++ ++ ++V++IF ++N + + + +
Sbjct: 460 KRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEVMNIYDSGSNNIQDAMQAVT 519
Query: 444 ILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFAL 503
LN++ + DE + P V K++T+G +MA SG PD+ H D AL
Sbjct: 520 TLNKVFSALDEEIISP---FVYKVETVGMVYMAVSGA-PDVNPL------HAEHACDLAL 569
Query: 504 EMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVP 563
+ K V H L +R+G N G V AGV+G Y ++GD VN ASRM+S+ P
Sbjct: 570 RVMKKVKA--HALP--GVAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDP 625
Query: 564 QRIQVGE-ACVPVLSARYEFEPRGSVYVKGKDDMNVYLLV 602
IQ+ + V Y+ E RG V VKGK +M Y L+
Sbjct: 626 WMIQLSNYTALKVQKVGYKVEARGFVKVKGKGEMETYWLL 665
>UniRef50_UPI00015B6145 Cluster: PREDICTED: similar to guanylate
cyclase; n=1; Nasonia vitripennis|Rep: PREDICTED: similar
to guanylate cyclase - Nasonia vitripennis
Length = 1542
Score = 103 bits (247), Expect = 1e-20
Identities = 79/238 (33%), Positives = 117/238 (49%), Gaps = 18/238 (7%)
Query: 371 NVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHKD-VAIIFASIINFNE 429
++V+ R + + + D LLH ++P VA+ L N D V I F+ I+ F
Sbjct: 924 DLVSERTRLLFEEKQKTED-LLHRMLPEPVANCLTNGIGVEPEAFDLVTIYFSDIVGFTA 982
Query: 430 MYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASR 489
M ES + + LN+L FD +++ V K++TIG +M SGL +++ +R
Sbjct: 983 MSAES--TPFQVVNFLNDLYTLFDRIIKG---YDVYKVETIGDAYMVVSGL--PIKNGNR 1035
Query: 490 GTYDHLYQLMDFALEMQKVVDNFN--HDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIW 547
H ++ +LE+ V + H E LRIG + G V AGV+G T Y ++
Sbjct: 1036 ----HAGEIASMSLELLNAVKHHTIAHRPSE-TLKLRIGIHTGPVVAGVVGLTMPRYCLF 1090
Query: 548 GDAVNIASRMDSTGVPQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDMNVYLLVG 603
GD VN ASRM+S G P RI + C L Y E RG V +KGK ++ Y L G
Sbjct: 1091 GDTVNTASRMESNGEPLRIHISAQCKDALDKIGGYVIEERGLVQMKGKGEVKTYWLTG 1148
>UniRef50_UPI0000F1EB17 Cluster: PREDICTED: similar to
ENSANGP00000011644; n=3; Euteleostomi|Rep: PREDICTED:
similar to ENSANGP00000011644 - Danio rerio
Length = 584
Score = 103 bits (247), Expect = 1e-20
Identities = 75/236 (31%), Positives = 122/236 (51%), Gaps = 16/236 (6%)
Query: 376 RDK-QRVQNMRNQADWLLHNIIPRHVADQLKNTAKY-SENHKDVAIIFASIINFNEMYDE 433
R+K + ++ R A+ LLH ++P+ VA QL+ + +E+++ V I F+ I+ F +
Sbjct: 282 REKTEDLKRERRLAEDLLHQMLPKSVAKQLRQNKHFEAESYEKVTIFFSDIVGFTAI--S 339
Query: 434 SYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYD 493
+ + + +LN L FD ++ V K++TIG +M SGL P+ R+ R +
Sbjct: 340 ASCTPLQVVEMLNNLYMCFDTRIDS---YDVYKVETIGDAYMVVSGL-PE-RNGDRHADE 394
Query: 494 HLYQLMDFALEMQKV-VDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVN 552
+D +++V + + + LR G + G AGV+G Y ++GD VN
Sbjct: 395 IAKMSLDLVAAVRQVPIPHMPTKRLQ----LRAGIHTGPCVAGVVGYKMPRYCLFGDTVN 450
Query: 553 IASRMDSTGVPQRIQVGEACVPVL--SARYEFEPRGSVYVKGKDDMNVYLLVGKKD 606
ASRM+ST +PQ+I A L YE + RG V VKGK M+ Y L+G K+
Sbjct: 451 TASRMESTSLPQKIHASSATYLALMKDNAYELQLRGEVEVKGKGKMDTYWLIGHKN 506
>UniRef50_Q9NGZ8 Cluster: Guanylyl cyclase; n=4; Caenorhabditis|Rep:
Guanylyl cyclase - Caenorhabditis elegans
Length = 1017
Score = 103 bits (247), Expect = 1e-20
Identities = 66/208 (31%), Positives = 112/208 (53%), Gaps = 17/208 (8%)
Query: 391 LLHNIIPRHVADQLKN-TAKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELI 449
LL+ ++P +A LKN +++ ++F I +FN + S ++ + LN++
Sbjct: 802 LLNEMLPASIAKDLKNGLIMPPRSYESATVMFVQICDFNALMKRS--SPEQVIAFLNDIY 859
Query: 450 ADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKV- 508
FD +++R K++T G T+M ASG+ H + G H++++ + +LE++++
Sbjct: 860 DQFDTVIKR---HDAYKVETTGETYMVASGVP----HENEGR--HIFEVAEISLEIREIS 910
Query: 509 -VDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQ 567
+ HD + +RIG++ G + AGVIG Y ++GD VN ASRM S P +IQ
Sbjct: 911 YIYVLQHDK-NYKLRIRIGFHAGPIAAGVIGIRSPRYCLFGDTVNFASRMQSNCPPNQIQ 969
Query: 568 VGEACVPVL--SARYEFEPRGSVYVKGK 593
E +L S Y+F RG V+VKGK
Sbjct: 970 TSEITARLLFDSHEYKFVKRGIVHVKGK 997
>UniRef50_Q10029 Cluster: Guanylate cyclase; n=1; Caenorhabditis
elegans|Rep: Guanylate cyclase - Caenorhabditis elegans
Length = 1118
Score = 103 bits (246), Expect = 2e-20
Identities = 74/251 (29%), Positives = 131/251 (52%), Gaps = 22/251 (8%)
Query: 366 LSFYSNVVANRDKQRVQNM---RNQADWLLHNIIPRHVADQLK-NTAKYSENHKDVAIIF 421
L Y++ + ++R + + + +AD LL ++P+ VA++LK E V + F
Sbjct: 816 LEEYTSTLEEEIEERTKELTLEKKKADILLSRMLPKQVAERLKAGQTVEPEGFDSVTVFF 875
Query: 422 ASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQH-VEKIKTIGSTFMAASGL 480
+ ++ F + S + + +LN+L ++FD ++E QH V K+++IG ++ SGL
Sbjct: 876 SDVVKFTIL--ASKCSPFQTVNLLNDLYSNFDTIIE----QHGVYKVESIGDGYLCVSGL 929
Query: 481 NPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFI-LRIGYNFGDVTAGVIGT 539
+R Y H+ Q++D +L+ + +F + + LRIG N G AGV+G
Sbjct: 930 ------PTRNGYAHIKQIVDMSLKFMEYCRSFKIPHLPRENVELRIGVNSGPCVAGVVGL 983
Query: 540 TKLYYDIWGDAVNIASRMDSTGVPQRIQV-GEACVPVLS---ARYEFEPRGSVYVKGKDD 595
+ Y ++GD VN ASRM+S G P I + +A + +L+ Y+ RG V +KGK
Sbjct: 984 SMPRYCLFGDTVNTASRMESNGKPSLIHLTSDAHLLLLTHYPNHYDTSSRGEVIIKGKGV 1043
Query: 596 MNVYLLVGKKD 606
M + + G+ D
Sbjct: 1044 METFWVHGRID 1054
>UniRef50_UPI0000ECB130 Cluster: Guanylate cyclase soluble subunit
beta-2 (EC 4.6.1.2) (GCS-beta-2).; n=2; Gallus
gallus|Rep: Guanylate cyclase soluble subunit beta-2 (EC
4.6.1.2) (GCS-beta-2). - Gallus gallus
Length = 659
Score = 102 bits (245), Expect = 2e-20
Identities = 68/230 (29%), Positives = 115/230 (50%), Gaps = 16/230 (6%)
Query: 379 QRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENH-KDVAIIFASIINFNEMYDESYLK 437
+ ++ + + + LL+ ++P+HVA+QLK + K+ I+F+ ++ F + + +
Sbjct: 432 KHLEEEKKKTEALLYAMLPQHVANQLKEGKRVEAGEFKECTILFSDVVTFTNICAQC--E 489
Query: 438 GKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLN-PDLRHASRGTYDHLY 496
+ + +LN + FD L V K++TIG +M G+ P HA R
Sbjct: 490 PIQIVLMLNSMYLQFDRLTT---VHDVYKVETIGDAYMVVGGVPVPVSTHAER------- 539
Query: 497 QLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASR 556
+ +FAL + + + +R+G + G V AGV+G Y ++GD VNIASR
Sbjct: 540 -IANFALGIIIAAKGVQNPVSGNPIQIRVGIHTGPVLAGVVGEKMPRYCLFGDTVNIASR 598
Query: 557 MDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSVYVKGKDDMNVYLLVGKK 605
M+S GVP +I + + L + +E RG + VKGK M+ Y LV K
Sbjct: 599 MESHGVPSKIHLSSSAYQCLKYKNFEMTERGEIEVKGKGKMHTYFLVRNK 648
>UniRef50_Q17AF9 Cluster: Guanylate cyclase; n=1; Aedes aegypti|Rep:
Guanylate cyclase - Aedes aegypti (Yellowfever mosquito)
Length = 987
Score = 102 bits (245), Expect = 2e-20
Identities = 75/234 (32%), Positives = 115/234 (49%), Gaps = 16/234 (6%)
Query: 372 VVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKY-SENHKDVAIIFASIINFNEM 430
+V R Q + + + + LL ++PR VA+ L + +EN V I F+ ++ F E+
Sbjct: 766 IVQERTNQLTEE-KKKTESLLLRMLPRSVAESLMRGERVEAENFDCVTIFFSDLVGFTEL 824
Query: 431 YDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRG 490
+S E + +LN+L D ++ V K++TIG +M SGL +R+ R
Sbjct: 825 CAQS--NPFEVVEMLNDLYTCCDFIISS---YDVYKVETIGDAYMVVSGL--PIRNGDR- 876
Query: 491 TYDHLYQLMDFALEMQKVVDNFNHDLFEFDFI-LRIGYNFGDVTAGVIGTTKLYYDIWGD 549
H ++ AL + + N +FI +RIG + G AGV+G Y ++GD
Sbjct: 877 ---HAGEIASLALHLLNSLSNLEIRHRPGEFIQIRIGIHSGQCVAGVVGLKMPRYCLFGD 933
Query: 550 AVNIASRMDSTGVPQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDMNVYLL 601
VN ASRM+STG +I + +L Y FE RG + VKGK DM Y L
Sbjct: 934 TVNTASRMESTGDAMKIHISSVTYNLLKKIGGYRFEERGVINVKGKGDMRTYWL 987
>UniRef50_O16715 Cluster: Guanylate cyclase; n=3; Caenorhabditis|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1119
Score = 102 bits (245), Expect = 2e-20
Identities = 78/237 (32%), Positives = 121/237 (51%), Gaps = 18/237 (7%)
Query: 373 VANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYS-ENHKDVAIIFASIINFNEMY 431
+A R+++ ++ + +++ LL ++P VAD LK + S E+ ++ + F+ F EM
Sbjct: 795 IAERNEE-LEGEKAKSEALLKMMLPEVVADSLKLGSNVSAESFENCTVFFSDCPGFVEMS 853
Query: 432 DESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLN-PDLRHASRG 490
S K + ++ LN+L FD +++ QF V K++TI +M ASGL P+ H
Sbjct: 854 ATS--KPIDIVQFLNDLYTVFDRIID--QFD-VYKVETIADAYMVASGLPVPNGNH---- 904
Query: 491 TYDHLYQLMDFALEMQKVVDNFN-HDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGD 549
H ++ L + K V++F L LRIG N G AGV+G Y ++GD
Sbjct: 905 ---HAGEIASLGLALLKAVESFKIRHLPNEKVRLRIGMNSGPCVAGVVGLKMPRYCLFGD 961
Query: 550 AVNIASRMDSTGVPQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDMNVYLLVGK 604
VN ASRM+S G+P RI +L YE E RG V +KGK Y + G+
Sbjct: 962 TVNTASRMESNGIPLRINCSGTAKEILDQLGGYEIEERGIVEMKGKGKQMTYFVRGE 1018
>UniRef50_Q1NWK5 Cluster: Guanylate cyclase; n=2; delta
proteobacterium MLMS-1|Rep: Guanylate cyclase - delta
proteobacterium MLMS-1
Length = 323
Score = 102 bits (244), Expect = 3e-20
Identities = 69/222 (31%), Positives = 108/222 (48%), Gaps = 16/222 (7%)
Query: 384 MRNQADWLLHNIIPRHVADQLKNTAKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLR 443
+ Q D LL N +P VA++++ ++ D I+F+ + F + +E L E +
Sbjct: 102 LEKQVDNLLKNTLPPMVAEEIRYLGSFAPRQYDCTILFSDVAGFTRLAEE--LSSVELVA 159
Query: 444 ILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFAL 503
I++++ FD ++ F KIKTIG +M G A DH + + AL
Sbjct: 160 IIDDIFRIFDRVVR--DFNGT-KIKTIGDAYMVVFG-------APVADEDHPVRAVRAAL 209
Query: 504 EMQKVVDNFNHDLFEFD----FILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDS 559
MQ+ + FN F F RIG + G VTAGV+G ++ +D++GD VNIA+R ++
Sbjct: 210 AMQEGLAVFNRQRFGAATAQYFRCRIGIHSGPVTAGVVGEDRMQFDVFGDHVNIAARFET 269
Query: 560 TGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLL 601
G P R+ + A L E RG V +K K M Y +
Sbjct: 270 AGEPGRVNISAATRQHLPPNLVCEDRGEVALKHKKAMRAYFV 311
>UniRef50_Q19768 Cluster: Guanylate cyclase; n=2; Caenorhabditis|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1025
Score = 102 bits (244), Expect = 3e-20
Identities = 72/239 (30%), Positives = 120/239 (50%), Gaps = 27/239 (11%)
Query: 373 VANRDKQRVQNMRNQADWLLHNIIPRHVADQLK-NTAKYSENHKDVAIIFASIINFNEMY 431
V R K+ V+ + ++D LL+ ++P+ VA++LK + E + V I F+ ++ F
Sbjct: 806 VQERMKELVEE-KKKSDILLYRMLPQQVAERLKLGQSVEPEAFESVTIFFSDVVGFT--- 861
Query: 432 DESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGT 491
+ +LN+L FD ++E+ K++TIG ++ SGL R
Sbjct: 862 ---------VVNLLNDLYTTFDAIIEKNDSY---KVETIGDAYLVVSGL------PRRNG 903
Query: 492 YDHLYQLMDFALEMQKVVDNFNHDLFEFDFI-LRIGYNFGDVTAGVIGTTKLYYDIWGDA 550
+H+ + + +LE+ + F + + +RIG + G AGV+G T Y ++GD
Sbjct: 904 TEHVANIANMSLELMDSLQAFKIPHLPQEKVQIRIGMHSGSCVAGVVGLTMPRYCLFGDT 963
Query: 551 VNIASRMDSTGVPQRIQVGEACVPVLSA---RYEFEPRGSVYVKGKDDMNVYLLVGKKD 606
VN ASRM+S G P I + C +L++ Y E RG V +KGK M Y L+G K+
Sbjct: 964 VNTASRMESNGKPGFIHLSSDCYDLLTSLYKEYNTESRGEVIIKGKGVMQTYWLLGMKE 1022
>UniRef50_A2FSM3 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1416
Score = 102 bits (244), Expect = 3e-20
Identities = 69/231 (29%), Positives = 123/231 (53%), Gaps = 14/231 (6%)
Query: 376 RDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHKDVA-IIFASIINFNEMYDES 434
+ + + + +++ LL+ I+P+ + +L K +A I F I+ F+ +
Sbjct: 1174 KKRNDAEQAKAKSEKLLYQILPKDIVVRLNRGEKDISFSIPIATIFFIDIVKFSNY--SA 1231
Query: 435 YLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL--NPDLRHASRGTY 492
L E ++ L+ + A FD+ + + +Q + KIK IG +MAA+GL N D + A
Sbjct: 1232 TLSPSEIMQNLSLVFATFDKNVSK--YQSITKIKLIGDVYMAAAGLFNNADEKTAK---- 1285
Query: 493 DHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGD-VTAGVIGTTKLYYDIWGDAV 551
DH + ++ L+ K + + N +L E +R+G N G + GV+GT K +DI GD +
Sbjct: 1286 DHATEAVNCCLQCIKSMTDINTNL-ESSLEVRVGVNSGGPLIGGVLGTDKPTFDIIGDPI 1344
Query: 552 NIASRMDSTGVPQRIQVGEACVPVL-SARYEFEPRGSVYVKGKDDMNVYLL 601
N+A+R+ ST +P +Q+ E ++ S+ + E RG VY+KGK + Y +
Sbjct: 1345 NVAARLQSTDIPGNVQISEETKNLIESSDFIIEERGEVYLKGKGNRKTYFV 1395
>UniRef50_UPI0000E4745B Cluster: PREDICTED: similar to
ENSANGP00000009149; n=2; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to ENSANGP00000009149
- Strongylocentrotus purpuratus
Length = 1319
Score = 101 bits (243), Expect = 4e-20
Identities = 75/236 (31%), Positives = 121/236 (51%), Gaps = 16/236 (6%)
Query: 371 NVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKY-SENHKDVAIIFASIINFNE 429
++V +R Q ++ + + D LLH ++P+ VA+QLK + E+ + V I F+ I+ F
Sbjct: 915 DIVEDRTHQLIEE-KKKTDNLLHQMLPKPVANQLKRGMQVVPESFECVTIFFSDIVGFTS 973
Query: 430 MYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASR 489
+ ES E + +LN+L FDE++ + V K++TIG +M SGL LR+ +
Sbjct: 974 LSSES--TPFEVVDMLNDLYTLFDEIIS---YYDVYKVETIGDAYMLVSGL--PLRNEKK 1026
Query: 490 GTYDHLYQLMDFALEMQKVVDNFN-HDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWG 548
H ++ +L + + V F E + LRIG + G +GV+G T Y ++G
Sbjct: 1027 ----HAAEIASTSLHLLEDVKAFKVRHRPEVNLKLRIGIHSGSTVSGVVGLTMPRYCLFG 1082
Query: 549 DAVNIASRMDSTGVPQRIQVGEACVPVLSARYEF--EPRGSVYVKGKDDMNVYLLV 602
D VN ASRM+S G +I +L F E RG + +KGK + Y L+
Sbjct: 1083 DTVNTASRMESNGEALKIHTSSETKNLLEQMGGFVVEERGLISMKGKGQLVTYWLI 1138
>UniRef50_Q75V80 Cluster: Guanylate cyclase; n=11; Euteleostomi|Rep:
Guanylate cyclase - Oryzias latipes (Medaka fish)
(Japanese ricefish)
Length = 859
Score = 101 bits (243), Expect = 4e-20
Identities = 74/240 (30%), Positives = 118/240 (49%), Gaps = 16/240 (6%)
Query: 372 VVANRDKQRVQNMRNQADWLLHNIIPRHVADQLK-NTAKYSENHKDVAIIFASIINFNEM 430
+VA R Q + + + + D LL++++P+ VAD L+ ++++ + F+ I+ F ++
Sbjct: 592 LVAERT-QDLTHEKQKTDRLLYSMLPKQVADDLRQGKPSQAQSYVSATVFFSDIVGFTQL 650
Query: 431 YDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRG 490
S + + LN+L FD +++ V K++TIG +M SG+ + G
Sbjct: 651 SSSS--TPYQVVDFLNKLYTTFDNIIDN---YDVYKVETIGDAYMVVSGVPQE-----NG 700
Query: 491 TYDHLYQLMDFALEMQKVVDNFN-HDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGD 549
H ++ AL++ V F +R G + G V AGV+GT Y ++GD
Sbjct: 701 IL-HASEIASMALDLVGVCRTFRIPHKPSMQLQIRAGIHSGPVVAGVVGTKMPRYCLFGD 759
Query: 550 AVNIASRMDSTGVPQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDMNVYLLVGKKDT 607
VN ASRM+ST +IQ + +L Y E RG VKGK DM Y L GKK T
Sbjct: 760 TVNTASRMESTSTALKIQCSSSTFYLLEEIGGYVLECRGVQQVKGKGDMVTYWLQGKKTT 819
>UniRef50_Q1EC29 Cluster: IP04501p; n=7; Endopterygota|Rep: IP04501p
- Drosophila melanogaster (Fruit fly)
Length = 710
Score = 101 bits (243), Expect = 4e-20
Identities = 76/243 (31%), Positives = 128/243 (52%), Gaps = 16/243 (6%)
Query: 366 LSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKY-SENHKDVAIIFASI 424
+ Y+ ++ + K+ ++ + ++D LL ++P VA QLK T + +E ++ V I F+ I
Sbjct: 442 IQLYALNLSQKAKE-LKREKRKSDSLLFQMLPPSVAMQLKQTQQVPAELYEAVTIYFSDI 500
Query: 425 INFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDL 484
+ F E+ + E + LN + FDE +E V K++TIG ++M ASGL +
Sbjct: 501 VGFTEIAADC--TPLEVVTFLNSIYRVFDERIE---CYDVYKVETIGDSYMVASGL--PV 553
Query: 485 RHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFI-LRIGYNFGDVTAGVIGTTKLY 543
++ ++ H+ ++ AL++ F +F+ +R G + G V AG++GT
Sbjct: 554 KNGNK----HISEIATMALDLLDASSVFRIPRAGDEFVQIRCGVHTGPVVAGIVGTKMPR 609
Query: 544 YDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDMNVYLL 601
Y ++GD VN ASRM+STG Q+I + E L + E RG + VKGK M+ Y L
Sbjct: 610 YCLFGDTVNTASRMESTGEAQKIHITEEMHDSLQQVGGFRTEHRGLIDVKGKGLMSTYWL 669
Query: 602 VGK 604
K
Sbjct: 670 TCK 672
>UniRef50_A2FLP2 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1568
Score = 101 bits (243), Expect = 4e-20
Identities = 66/230 (28%), Positives = 124/230 (53%), Gaps = 14/230 (6%)
Query: 376 RDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK-YSENHKDVAIIFASIINFNEMYDES 434
+ +++ + + +++ LL I+PR + +L K + I+F I+ F++ +
Sbjct: 1325 KKQEQAELAKKKSEELLFQILPRDIVFKLNQGEKDITFTVPSATIMFIDIVRFSDY--AA 1382
Query: 435 YLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL-NPDLRHASRGTYD 493
L ++ + L+ + FD L + + KIK IG +M A+GL PD + +
Sbjct: 1383 NLTPQQIMGNLSLIFDTFDRHLT--DYPLITKIKLIGDVYMCAAGLFTPDGQ-----PQE 1435
Query: 494 HLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGD-VTAGVIGTTKLYYDIWGDAVN 552
H Q++ FA++ + ++N N L E +RIG N G + G++GT K +DI GD +N
Sbjct: 1436 HAQQMLHFAIDCLQEIENINVTL-ESMLAVRIGVNTGGPLIGGILGTDKPVFDIIGDPIN 1494
Query: 553 IASRMDSTGVPQRIQVGEACVPVL-SARYEFEPRGSVYVKGKDDMNVYLL 601
+ASR+ ST +P ++Q+ ++ ++ + + E RG VY+KGK ++ YL+
Sbjct: 1495 VASRLQSTDIPGKVQIPQSVFDLVHNLDFNIEKRGEVYLKGKGNVTTYLV 1544
>UniRef50_A2DY07 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1588
Score = 101 bits (243), Expect = 4e-20
Identities = 66/228 (28%), Positives = 123/228 (53%), Gaps = 14/228 (6%)
Query: 378 KQRVQNMRNQADWLLHNIIPRHVADQLKNTAK-YSENHKDVAIIFASIINFNEMYDESYL 436
+++ + + +++ LL I+PR + +L K + I+F I+ F++ + L
Sbjct: 1348 QEQAELAKKKSEELLFQILPRDIVFKLNQGEKDITFTVPSATIMFIDIVRFSDY--AANL 1405
Query: 437 KGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL-NPDLRHASRGTYDHL 495
++ + L+ + FD+ L + + KIK IG +M A+GL PD + DH
Sbjct: 1406 TPQQIMGNLSLIFDTFDKHLT--DYPLITKIKLIGDVYMCAAGLFTPDGQ-----LQDHA 1458
Query: 496 YQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGD-VTAGVIGTTKLYYDIWGDAVNIA 554
Q++ FA++ ++N N L E +R+G N G + G++GT K +DI GD +N+A
Sbjct: 1459 QQMLRFAIDCLAEIENINVAL-ESMLSVRVGVNTGGPLIGGILGTDKPVFDIIGDPINVA 1517
Query: 555 SRMDSTGVPQRIQVGEACVPVLSA-RYEFEPRGSVYVKGKDDMNVYLL 601
+R+ ST +P ++Q+ ++ ++ A + E RG VY+KGK ++ YL+
Sbjct: 1518 ARLQSTDIPGKVQIPQSVYDLVHAMEFNIEKRGEVYLKGKGNVTTYLV 1565
>UniRef50_UPI0000F2B0A8 Cluster: PREDICTED: similar to guanylyl
cyclase-G; n=6; Euteleostomi|Rep: PREDICTED: similar to
guanylyl cyclase-G - Monodelphis domestica
Length = 1111
Score = 101 bits (242), Expect = 6e-20
Identities = 76/238 (31%), Positives = 118/238 (49%), Gaps = 18/238 (7%)
Query: 372 VVANRDKQRVQNMRNQADWLLHNIIPRHVADQLK-NTAKYSENHKDVAIIFASIINFNEM 430
VV R Q + + + + LL ++P + +QL + E V I F+ I+ F ++
Sbjct: 830 VVEERTTQ-LMSEKKKIHTLLSTMLPSFIGEQLMAGRSVEPEQFDSVTIFFSDIVGFTKL 888
Query: 431 YDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRG 490
S + + +LN+L + FD +++ V K++TIG +M ASGL R
Sbjct: 889 CSLS--TPLQVVGLLNDLYSLFDNIIKT---YDVYKVETIGDAYMVASGL------PLRN 937
Query: 491 TYDHLYQLMDFALEMQKVVDNFN--HDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWG 548
H+ ++ +L VV +F H E LRIG + G V AGV+G T Y ++G
Sbjct: 938 GIQHVEEIATMSLHFLSVVVHFKIGHKPEE-KLKLRIGLHTGPVVAGVVGITMPRYCLFG 996
Query: 549 DAVNIASRMDSTGVPQRIQVGEACVPVLSA--RYEFEPRGSVYVKGKDDMNVYLLVGK 604
D VN+ASRM+S +P RI V + L + Y + RG++ VKGK + Y L GK
Sbjct: 997 DTVNMASRMESNSLPLRIHVSQTTASALRSVGGYVLQERGTIKVKGKGEQTTYWLKGK 1054
>UniRef50_UPI0000E45ED9 Cluster: PREDICTED: similar to
ENSANGP00000009149; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to ENSANGP00000009149
- Strongylocentrotus purpuratus
Length = 1268
Score = 101 bits (242), Expect = 6e-20
Identities = 74/235 (31%), Positives = 122/235 (51%), Gaps = 16/235 (6%)
Query: 372 VVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKY-SENHKDVAIIFASIINFNEM 430
+V +R +Q V+ + + + LLH ++P+ VA+QLK + E+ V I F+ I+ F ++
Sbjct: 833 IVEDRTQQLVEE-KKKTENLLHRMLPKPVANQLKRGMQVVPESFDCVTIFFSDIVGFTKL 891
Query: 431 YDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRG 490
S + + +LN+L FD+++ + +V K++TIG +M SGL +R+ +R
Sbjct: 892 --SSMSTPFQVVDLLNDLYTLFDDIIS---YYNVYKVETIGDAYMLVSGL--PIRNDNR- 943
Query: 491 TYDHLYQLMDFALEMQKVVDNFNHDLFEFDFI-LRIGYNFGDVTAGVIGTTKLYYDIWGD 549
H ++ AL + V F D + LR+G + G V GV+G T Y ++GD
Sbjct: 944 ---HAAEIGSTALHLIDEVQKFKIRHRPDDTLKLRVGIHSGPVVTGVVGLTMPRYCLFGD 1000
Query: 550 AVNIASRMDSTGVPQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDMNVYLLV 602
VN +SRM+S G +I C +L Y+ RG V +KGK + Y LV
Sbjct: 1001 TVNTSSRMESNGEALKIHCSAECKAILDEVGGYDVPERGIVAMKGKGSLLTYWLV 1055
>UniRef50_O77149 Cluster: NO-insensitive guanylyl cyclase; n=1;
Manduca sexta|Rep: NO-insensitive guanylyl cyclase -
Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Length = 500
Score = 101 bits (242), Expect = 6e-20
Identities = 76/224 (33%), Positives = 113/224 (50%), Gaps = 13/224 (5%)
Query: 385 RNQADWLLHNIIPRHVADQL-KNTAKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLR 443
+ + + LL+ ++P+ VA QL +E + V I F+ II F ++ ES E +
Sbjct: 131 KRKCEELLYQLLPKSVASQLIMGQPVMAETYDQVTIYFSDIIGFTQLSAES--TPLEVVD 188
Query: 444 ILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFAL 503
+LN+L FD ++E F V K++TIG +M SGL +R+ +R + M AL
Sbjct: 189 LLNDLYTSFDSIIEN--FD-VYKVETIGDAYMVVSGL--PMRNGNRHAAE--IARMSLAL 241
Query: 504 EMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVP 563
V H E +LRIG + G AGV+G Y ++GD VN ASRM+S G
Sbjct: 242 LNAVRVKTVPHRPGE-RLLLRIGMHTGPCVAGVVGLKMPRYCLFGDTVNTASRMESHGEA 300
Query: 564 QRIQVGEACVPVLSAR--YEFEPRGSVYVKGKDDMNVYLLVGKK 605
+I V VL +E + RG + +KGK M Y L+G+K
Sbjct: 301 LKIHVSPKTKEVLDLYDCFELDCRGEITMKGKGKMTTYWLLGEK 344
>UniRef50_A2EII5 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1612
Score = 101 bits (242), Expect = 6e-20
Identities = 74/228 (32%), Positives = 119/228 (52%), Gaps = 14/228 (6%)
Query: 378 KQRVQNMRNQADWLLHNIIPRHVADQLKNTAK-YSENHKDVAIIFASIINFNEMYDESYL 436
K++ + + +++ LL+ I+PR + +L K S IIF I F+E Y ++ L
Sbjct: 1292 KKQAEEAKMKSEKLLYQILPRDIVLKLNKGEKDISFVVPSATIIFIDINKFSE-YSKN-L 1349
Query: 437 KGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL-NPDLRHASRGTYDHL 495
+ + L+ A D + + + ++KIK IG +MAASGL NPD S H
Sbjct: 1350 TPQAIMSNLSYYFAQLDRVAGK--YGMIQKIKLIGDIYMAASGLFNPDSPPES-----HA 1402
Query: 496 YQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGD-VTAGVIGTTKLYYDIWGDAVNIA 554
Q + F+L +D+ N L + +RIG N G + AGV+GT K +DI GD +N+A
Sbjct: 1403 EQAVQFSLACLDALDDVNIHL-DSHLEIRIGINSGGPIIAGVLGTDKPVFDIIGDPINVA 1461
Query: 555 SRMDSTGVPQRIQVGEACVPVL-SARYEFEPRGSVYVKGKDDMNVYLL 601
+R+ ST R+ V +A + ++ + YE PRG ++KGK Y +
Sbjct: 1462 ARLQSTSEVNRVHVSQATLSLINNITYEVTPRGETFLKGKGKQLTYYI 1509
>UniRef50_UPI0000F1D453 Cluster: PREDICTED: similar to receptor type
guanylyl cyclase; n=3; Danio rerio|Rep: PREDICTED:
similar to receptor type guanylyl cyclase - Danio rerio
Length = 479
Score = 101 bits (241), Expect = 7e-20
Identities = 71/237 (29%), Positives = 125/237 (52%), Gaps = 16/237 (6%)
Query: 372 VVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-KNTAKYSENHKDVAIIFASIINFNEM 430
+V+ R + +Q + +A+ LL ++PR VA QL +E + V I F+ I F M
Sbjct: 253 IVSERTAE-LQEEKKRAEGLLTQMLPRSVASQLIAGKTVRAETYDCVTIYFSDIEGFTAM 311
Query: 431 YDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRG 490
+ L + + +LN+L FD +++ + +V K++TIG +M SGL +R+
Sbjct: 312 --SASLTPMQVVNVLNDLYTYFDNIID---YHNVYKVETIGDAYMVVSGL--PIRNGD-- 362
Query: 491 TYDHLYQLMDFALEMQKVVDNFNHD-LFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGD 549
DH ++ +L + + + +F+ + E +RIG + G AGV+G Y ++GD
Sbjct: 363 --DHAKEIARMSLAIVQGLRSFHSPHVPEQQLRVRIGVHSGPCVAGVVGLKMPRYCLFGD 420
Query: 550 AVNIASRMDSTGVPQRIQVGEACVPVLSA--RYEFEPRGSVYVKGKDDMNVYLLVGK 604
VN ASRM+S G+P +I V + +L + E RG +++KGK + + L+G+
Sbjct: 421 TVNTASRMESYGLPLKIHVSSSTKSLLDTFRNFRCELRGDIHIKGKGWVRTFWLLGE 477
>UniRef50_UPI0000E46159 Cluster: PREDICTED: similar to natriuretic
peptide receptor A; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to natriuretic
peptide receptor A - Strongylocentrotus purpuratus
Length = 853
Score = 101 bits (241), Expect = 7e-20
Identities = 70/225 (31%), Positives = 113/225 (50%), Gaps = 17/225 (7%)
Query: 385 RNQADWLLHNIIPRHVADQLK-NTAKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLR 443
+ +++ LL+ ++PR VA+QLK + E++++V I F+ I+ F + ES + +
Sbjct: 632 KKRSETLLYEVLPRSVAEQLKLGKSVDPESYENVTIFFSDIVGFTAISSES--TPLQVVA 689
Query: 444 ILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFAL 503
+LN+L FD ++ V K++TIG +M SGL R H ++ + +L
Sbjct: 690 LLNDLYICFDGIIANSD---VYKVETIGDAYMVVSGL------PIRNGITHAREIAEMSL 740
Query: 504 EMQKVVDNFN--HDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTG 561
+ + V +F H E LR G + G AGVIG Y ++GD VN ASRM+S G
Sbjct: 741 SLLEAVKSFKIRHRPDE-QLKLRAGIHSGPCVAGVIGLKMPRYCLFGDTVNTASRMESNG 799
Query: 562 VPQRIQVGEACVPVLSA--RYEFEPRGSVYVKGKDDMNVYLLVGK 604
+I C +L +E + RG V +KGK Y L+ +
Sbjct: 800 EAMKIHASSDCKEILDKFDAFELDLRGQVEMKGKGSQTTYWLLSR 844
>UniRef50_UPI0000586706 Cluster: PREDICTED: similar to guanylate
cyclase; n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to guanylate cyclase -
Strongylocentrotus purpuratus
Length = 650
Score = 101 bits (241), Expect = 7e-20
Identities = 68/224 (30%), Positives = 111/224 (49%), Gaps = 15/224 (6%)
Query: 385 RNQADWLLHNIIPRHVADQLK-NTAKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLR 443
R + D LL+ ++P VA+ LK N ++EN I+F+ I+ F + ES + +
Sbjct: 409 RKRTDTLLYQMLPISVAENLKRNQVVHAENFTAATILFSDIVGFTRICSES--SPLQVVD 466
Query: 444 ILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFAL 503
+LN + FD ++ +V K++TIG +M SG+ R H ++ AL
Sbjct: 467 MLNNVYTKFDSRIDT---YNVYKVETIGDAYMVVSGV------PQRNGNKHASEIALMAL 517
Query: 504 EMQKVVDNFNHDLFE-FDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGV 562
++ + LRIG + G V AG++G+ Y ++G+ VNIAS+M+S G+
Sbjct: 518 DLLNCIKGLVIPHRPGTKMTLRIGIHTGPVVAGIVGSKMPRYCLFGETVNIASKMESNGL 577
Query: 563 PQRIQVGEACVPVL--SARYEFEPRGSVYVKGKDDMNVYLLVGK 604
P RIQ+ + C +L + Y RG V + K M Y L G+
Sbjct: 578 PNRIQISDDCHRILKITGGYTMVRRGEVLLTDKGTMTTYWLTGR 621
>UniRef50_Q17BS6 Cluster: Guanylate cyclase; n=2; Culicidae|Rep:
Guanylate cyclase - Aedes aegypti (Yellowfever mosquito)
Length = 574
Score = 101 bits (241), Expect = 7e-20
Identities = 69/223 (30%), Positives = 115/223 (51%), Gaps = 15/223 (6%)
Query: 385 RNQADWLLHNIIPRHVADQLKNTAKY-SENHKDVAIIFASIINFNEMYDESYLKGKEYLR 443
++++D LL+ ++P V QLK + +E + V I F+ I+ F Y + E +
Sbjct: 332 KSKSDRLLYQMLPPAVVRQLKQQRQVPAETFESVTIFFSDIVGFT--YISAVSTAMEVVT 389
Query: 444 ILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFAL 503
+LN L FD ++ + V K++TIG +M SGL P R+ + + +D
Sbjct: 390 MLNTLYRLFDTIILK---YDVYKVETIGDAYMVVSGL-PQ-RNGDKHAGEIAMMSLDLLC 444
Query: 504 EMQK-VVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGV 562
+ ++ + + E +R+G N G AGV+GTT Y ++GD +N ASRM+STG
Sbjct: 445 GISGFIIPHMKNRTLE----IRVGVNTGPCVAGVVGTTMPRYCLFGDTINTASRMESTGE 500
Query: 563 PQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDMNVYLLVG 603
P +I + E +L ++ + RG++ VKGK M + LVG
Sbjct: 501 PMKIHLSENTKEILDKLGGFKIKRRGTIEVKGKGTMETFWLVG 543
>UniRef50_A7RN70 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 629
Score = 101 bits (241), Expect = 7e-20
Identities = 71/255 (27%), Positives = 132/255 (51%), Gaps = 18/255 (7%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSEN-HK 415
N EF++S RL ++ + ++ ++N + D LL++I+P VA+ L+ + N ++
Sbjct: 371 NAEFKLSQRLEILTDKLQQTSRE-LENEQQLNDRLLYSILPASVANDLRLRKPVNANKYE 429
Query: 416 DVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFM 475
V I+F+ I++F Y + E + +LNE+ +FD+L + + K++T+G +M
Sbjct: 430 IVTIMFSGIVDFTN-YCNKIKEPMEIVEMLNEVYTEFDQLTDSND--DIYKVETVGDKYM 486
Query: 476 AASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAG 535
A SGL H + + AL+M + + + IG + G+V AG
Sbjct: 487 AVSGLPTRCDK-------HALNIANLALDMIDISKGMKAKGIQLQ--VTIGIHSGEVVAG 537
Query: 536 VIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGE---ACVPVL-SARYEFEPRGSVYVK 591
V+G K Y ++G+ VN+ SR ++TG+ +I V E C+ V ++ F+ RG V +K
Sbjct: 538 VVGQKKPRYCLFGNTVNLTSRTETTGLKGKINVSEYAYRCLLVQPHEQFVFKKRGPVVMK 597
Query: 592 GKDDMNVYLLVGKKD 606
GK + + ++ + D
Sbjct: 598 GKKEPMITYILQRND 612
>UniRef50_A2FKW6 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1523
Score = 101 bits (241), Expect = 7e-20
Identities = 69/229 (30%), Positives = 116/229 (50%), Gaps = 15/229 (6%)
Query: 376 RDKQRVQNMRNQADWLLHNIIPRHVADQL-KNTAKYSENHKDVAIIFASIINFNEMYDES 434
+ ++ + + ++ LL+ I+PR + +L ++ + I F I+ F+E S
Sbjct: 1263 KQQEEAEKAKATSEKLLYQILPRDIVIRLNRDETDITFTVNSSTICFIDIVKFSEY--SS 1320
Query: 435 YLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDH 494
+L +E + L+ D + + F + KIK IG +M ASGL D + +H
Sbjct: 1321 HLSPQEIMYNLSYFFGTIDTISSK--FNLLTKIKVIGDIYMCASGLFDD-------SNEH 1371
Query: 495 LYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAG-VIGTTKLYYDIWGDAVNI 553
Q++ FA E + +D N L + + +RIG N G G V+G K +DI GD +N+
Sbjct: 1372 AEQMILFANEFVRELDEINIKL-DCNLSVRIGVNSGGPILGCVLGKEKPVFDIIGDPINV 1430
Query: 554 ASRMDSTGVPQRIQVGEACVPVLS-ARYEFEPRGSVYVKGKDDMNVYLL 601
ASR+ ST P I + + ++S ++ +PRG VY+KGK N YL+
Sbjct: 1431 ASRLQSTSPPNCIHMSQGTYDMVSNLNFDIKPRGEVYLKGKGKTNTYLM 1479
>UniRef50_UPI0000E49095 Cluster: PREDICTED: similar to guanylate
cyclase; n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to guanylate cyclase -
Strongylocentrotus purpuratus
Length = 699
Score = 100 bits (240), Expect = 1e-19
Identities = 75/225 (33%), Positives = 113/225 (50%), Gaps = 17/225 (7%)
Query: 385 RNQADWLLHNIIPRHVADQLKNTAKYSENHKDVA-IIFASIINFNEMYDESYLKGKEYLR 443
+ +A+WLL +++P VA+QL + D A + FA I F+ + ES + +
Sbjct: 432 KKRANWLLCSMLPETVANQLMHGYNVQAEWYDSATVFFADIFGFSRLCAES--SPMQVVE 489
Query: 444 ILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFAL 503
+LN L FD +E V K++TI T+M ASGL +R + H ++ AL
Sbjct: 490 MLNGLYLVFDSRIEH---YDVYKVETINETYMLASGL--PVRKGDQ----HAGEVATIAL 540
Query: 504 EMQKVVDNFN--HDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTG 561
++Q V H E +R+G + G V A V+G Y ++GD VNIASRM +TG
Sbjct: 541 DLQYHVSFLEVPHKRNE-KLTIRVGIHSGPVVAAVVGLKMPRYCLFGDTVNIASRMQTTG 599
Query: 562 VPQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDMNVYLLVGK 604
VP R+Q+ L+ Y+ RG + +KGK + Y L GK
Sbjct: 600 VPGRVQISYETFAALNDLGGYKVVKRGEIEIKGKGLLTTYWLNGK 644
>UniRef50_A0QDI3 Cluster: Adenylate and Guanylate cyclase catalytic
domain protein; n=13; Mycobacterium|Rep: Adenylate and
Guanylate cyclase catalytic domain protein -
Mycobacterium avium (strain 104)
Length = 731
Score = 100 bits (240), Expect = 1e-19
Identities = 67/226 (29%), Positives = 117/226 (51%), Gaps = 16/226 (7%)
Query: 378 KQRVQNMRNQADWLLHNIIPRHVADQLKNTAK-YSENHKDVAIIFASIINFNEMYDESYL 436
++ + R + D LL ++P V + + + ++ H+DVAII+A I+ +E++ E +
Sbjct: 518 EELLNEQRRENDRLLLALMPESVLQRYREGEETIAQKHQDVAIIYADIVGLDELFTE--M 575
Query: 437 KGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL-NPDLRHASRGTYDHL 495
+ + ++EL FD E VE+I+T + ++A+ G+ P L D +
Sbjct: 576 PEAQLVGTVDELFRQFDSAAET---LGVERIRTFHNGYLASCGVVTPRL--------DSI 624
Query: 496 YQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIAS 555
++ +DFALE+ +++D FN LRIG N G+V +G++G + L YD+WG AV++A
Sbjct: 625 HRAVDFALEIGRIIDRFNSQTGH-QLGLRIGVNTGNVVSGLVGRSGLVYDMWGGAVSLAY 683
Query: 556 RMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLL 601
+M S I V + +F P G++ V G D LL
Sbjct: 684 QMHSGSPQPGIYVSSQVYEAMRDVRQFAPAGTISVGGTDQAIYRLL 729
>UniRef50_Q9VF17 Cluster: Guanylate cyclase; n=7; Endopterygota|Rep:
Guanylate cyclase - Drosophila melanogaster (Fruit fly)
Length = 1417
Score = 100 bits (240), Expect = 1e-19
Identities = 78/247 (31%), Positives = 123/247 (49%), Gaps = 18/247 (7%)
Query: 365 RLSFYSNVVANRDKQRVQNM---RNQADWLLHNIIPRHVADQL-KNTAKYSENHKDVAII 420
R+ Y+N + ++R Q+ + + + LL+ ++P+ VA QL +E V I
Sbjct: 896 RMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIY 955
Query: 421 FASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL 480
F+ I+ F + ES + ++ LN+L FD ++E F V K++TIG +M SGL
Sbjct: 956 FSDIVGFTAISAES--TPMQVVQFLNDLYTCFDSIVEN--FD-VYKVETIGDAYMVVSGL 1010
Query: 481 NPDLRHASRGTYDHLYQLMDFALEMQKVVDNFN-HDLFEFDFILRIGYNFGDVTAGVIGT 539
+R+ ++ H ++ AL + + V NF H E LRIG + G AGV+G
Sbjct: 1011 --PIRNGNQ----HAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGL 1064
Query: 540 TKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDMN 597
Y ++GD VN ASRM+S G +I + E L + RG V +KGK +M
Sbjct: 1065 KMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEML 1124
Query: 598 VYLLVGK 604
Y L G+
Sbjct: 1125 TYWLEGE 1131
>UniRef50_UPI0000D5787E Cluster: PREDICTED: similar to CG9783-PA; n=2;
Endopterygota|Rep: PREDICTED: similar to CG9783-PA -
Tribolium castaneum
Length = 1044
Score = 100 bits (239), Expect = 1e-19
Identities = 77/246 (31%), Positives = 121/246 (49%), Gaps = 19/246 (7%)
Query: 366 LSFYSNVVANRDKQRVQNM---RNQADWLLHNIIPRHVADQLKNTAKYS-ENHKDVAIIF 421
L YSN + ++R + + + + + LL+ ++P VA++LK E ++V I F
Sbjct: 797 LEKYSNNLEELIRERTEQLDIEKKKTEQLLNRMLPSSVAEKLKLGMPVDPEEFEEVTIYF 856
Query: 422 ASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLN 481
+ I+ F + ++ + + +LN+L FD + +V K++TIG +M GL
Sbjct: 857 SDIVGFTTI--SAHSTPFQVVDLLNDLYTCFDATINA---YNVYKVETIGDAYMVVGGLP 911
Query: 482 PDLRHASRGTYDHLYQLMDFALEMQKVVDNFN-HDLFEFDFILRIGYNFGDVTAGVIGTT 540
+ DH Q+ AL++ F L LRIG + G AGV+G T
Sbjct: 912 VRVP-------DHAEQIATMALDLLHQSGRFRITHLPGTPLRLRIGLHTGPCCAGVVGLT 964
Query: 541 KLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL--SARYEFEPRGSVYVKGKDDMNV 598
Y ++GD VN ASRM+STG RI + EA L + Y+ E RG +KGK M+
Sbjct: 965 MPRYCLFGDTVNTASRMESTGAAWRIHLSEATKERLEKAGGYQLEYRGPTEIKGKGTMHT 1024
Query: 599 YLLVGK 604
Y L+GK
Sbjct: 1025 YWLLGK 1030
>UniRef50_P16066 Cluster: Atrial natriuretic peptide receptor A
precursor; n=57; Chordata|Rep: Atrial natriuretic peptide
receptor A precursor - Homo sapiens (Human)
Length = 1061
Score = 100 bits (239), Expect = 1e-19
Identities = 81/249 (32%), Positives = 123/249 (49%), Gaps = 20/249 (8%)
Query: 365 RLSFYSNVVANRDKQRVQ---NMRNQADWLLHNIIPRHVADQLKN-TAKYSENHKDVAII 420
R+ Y+N + ++R Q + +A+ LL+ I+P VA+QLK +E V I
Sbjct: 819 RMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIY 878
Query: 421 FASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL 480
F+ I+ F + ES + + +LN+L FD +++ F V K++TIG +M SGL
Sbjct: 879 FSDIVGFTALSAES--TPMQVVTLLNDLYTCFDAVIDN--FD-VYKVETIGDAYMVVSGL 933
Query: 481 NPDLRHASRGTYDHLYQLMDFALEMQKVVDNFN--HDLFEFDFILRIGYNFGDVTAGVIG 538
R H ++ AL + V +F H E LRIG + G V AGV+G
Sbjct: 934 ------PVRNGRLHACEVARMALALLDAVRSFRIRHRPQE-QLRLRIGIHTGPVCAGVVG 986
Query: 539 TTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDM 596
Y ++GD VN ASRM+S G +I + VL +E E RG V +KGK +
Sbjct: 987 LKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKV 1046
Query: 597 NVYLLVGKK 605
Y L+G++
Sbjct: 1047 RTYWLLGER 1055
>UniRef50_A6FX69 Cluster: Adenylate or guanylate cyclase; n=1;
Plesiocystis pacifica SIR-1|Rep: Adenylate or guanylate
cyclase - Plesiocystis pacifica SIR-1
Length = 601
Score = 99 bits (238), Expect = 2e-19
Identities = 63/213 (29%), Positives = 114/213 (53%), Gaps = 10/213 (4%)
Query: 391 LLHNIIPRHVADQLKNTAKYS-ENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELI 449
LL +++P + +LK + ++H+D ++FA ++ F + + L+ + + L+ L
Sbjct: 370 LLLDVMPASIVRELKLHQRVDPKHHEDATVVFADLVGFTRI--STTLEPRSLVAELDRLF 427
Query: 450 ADFDELLERPQFQHVEKIKTIGSTFMAASGL-NPDLRHASRGTYDHLYQLMDFALEMQKV 508
FD++ R Q +EK+KTIG +MA +GL +P RHA T L+ + A+
Sbjct: 428 RAFDDVAARWQ---LEKLKTIGDAYMAVAGLPDPHPRHALAATLAALH--LREAVRAYAA 482
Query: 509 VDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQV 568
+ + + + +R+G + G + AG+IG KL YD+WG+ VN A+RM+S+ RI V
Sbjct: 483 SPAADGQI-KPPWSVRVGLHSGPLIAGIIGRAKLAYDVWGETVNTAARMESSSAADRINV 541
Query: 569 GEACVPVLSARYEFEPRGSVYVKGKDDMNVYLL 601
++A + PRG V KG ++++ +
Sbjct: 542 SAPTHAQIAAYFVTTPRGPVEAKGLGPVDMFFV 574
>UniRef50_A3WBP2 Cluster: Adenylate/guanylate cyclase; n=1;
Erythrobacter sp. NAP1|Rep: Adenylate/guanylate cyclase
- Erythrobacter sp. NAP1
Length = 420
Score = 99 bits (238), Expect = 2e-19
Identities = 58/222 (26%), Positives = 114/222 (51%), Gaps = 13/222 (5%)
Query: 381 VQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHKDVAIIFASIINFNEMYDESYLKGKE 440
++ R + + +L N++P++VA++L+ +++ DV+++F I+ F+++ + L
Sbjct: 201 LEEERAKTEEMLFNVLPKNVANRLRRGEVVADSFSDVSVVFVDIVGFSKLARK--LSPGH 258
Query: 441 YLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMD 500
+++LN + DE + VEK+KTIG ++A +G + T + +
Sbjct: 259 LVKLLNAIFGLADECAKNAG---VEKVKTIGDAYLAVAG-------GTTSTENDAVSAIR 308
Query: 501 FALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDST 560
FA +M V ++ + D +R+G + G V GVIG ++ YD WGD +N A+R++
Sbjct: 309 FAEQMIAAVTDYARET-RIDVAIRVGIHTGPVVGGVIGQQRMAYDYWGDTMNTAARLEGV 367
Query: 561 GVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLLV 602
P I V E+ ++ +F P +KG + VY ++
Sbjct: 368 AKPGGIAVSESTYFAACSQVDFTPAELQTLKGIGETKVYRVI 409
>UniRef50_Q9VK53 Cluster: CG5983-PA, isoform A; n=13; Sophophora|Rep:
CG5983-PA, isoform A - Drosophila melanogaster (Fruit
fly)
Length = 1130
Score = 99 bits (238), Expect = 2e-19
Identities = 91/290 (31%), Positives = 148/290 (51%), Gaps = 56/290 (19%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADW-LLHNIIPRHVAD-QLKNTAK---YSE 412
R+ E + ++++ NV ++KQ+ ++ NQ+ LL+NI+P HV D L + AK Y E
Sbjct: 806 RQSEFNTKMNYKLNVDL-QNKQKAADLTNQSIIILLNNILPSHVVDLYLNSLAKHELYYE 864
Query: 413 NHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLER-PQFQHVEKIKTI- 470
N++ V+++FA +INF LR+LN++I FD LL ++ VEKIK +
Sbjct: 865 NYRMVSVMFAMLINFPMNLPS--------LRVLNDIITQFDRLLTAYREYYVVEKIKVVG 916
Query: 471 -------GSTFMAASG-----------LNPDLRHASRG-----TYDH-------LYQLMD 500
G F AS L+ ++ HA YD ++ +
Sbjct: 917 CTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDENYDSDMNNDEVVFIMTT 976
Query: 501 FALEMQKVVDNFNH----DLFEFDFI---LRIGYNFGDVTAGVIGTTKLYYDIWGDAVNI 553
FAL++ + + N FE + IG + G++ AGV+G ++ +YDIWG+ VN+
Sbjct: 977 FALDLMRTLAACNRAYSSSFFERSLSQGKICIGISSGEIMAGVVGASQPHYDIWGNPVNM 1036
Query: 554 ASRMDSTGVPQRIQVGEACVPVLSARYEFE--PRGSVYVKGKDDMNVYLL 601
ASRM+STG+P IQV E +L ++ + RG +VKG+ D+ Y +
Sbjct: 1037 ASRMESTGLPGHIQVTEESAKILQ-EFDIKCIYRGMTFVKGRGDIPTYFV 1085
Score = 70.9 bits (166), Expect = 9e-11
Identities = 47/165 (28%), Positives = 83/165 (50%), Gaps = 15/165 (9%)
Query: 414 HKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGST 473
H DV+I++A ++N+ + + L +++L++L FD + F+ V++IK +G
Sbjct: 312 HPDVSILYADVVNYTHL--TTTLTVGNLVKVLHDLYGRFD--IAASNFK-VQRIKFLGDC 366
Query: 474 FMAASGLN-PDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDV 532
+ +GL PD DH + + M + + D +RIG + G +
Sbjct: 367 YYCVAGLTTPDP--------DHAKCCVSLGISMISNIQEVRAER-GLDIDMRIGVHSGSL 417
Query: 533 TAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLS 577
AG+IG KL +DIWG V IA+ ++STG P + V + +L+
Sbjct: 418 LAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSMLN 462
>UniRef50_Q7YXG1 Cluster: Soluble guanylyl cyclase 2 beta; n=1;
Limax marginatus|Rep: Soluble guanylyl cyclase 2 beta -
Limax marginatus
Length = 406
Score = 99 bits (238), Expect = 2e-19
Identities = 71/250 (28%), Positives = 124/250 (49%), Gaps = 15/250 (6%)
Query: 359 EFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKN-TAKYSENHKDV 417
E +I+ +L + R + ++ + + + LL+ ++P VA+QLKN A +E V
Sbjct: 3 EIDITKKLD-ETTAELKRTSRELEMEKQKTERLLYQMLPEKVANQLKNGQAVEAEKFDQV 61
Query: 418 AIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAA 477
++F+ I+ F ++ S + +++LN++ FD+ + V K++TIG +M
Sbjct: 62 TVLFSDIVTFTDI--ASACSPMDIVKMLNDMYNRFDK---KTNEHGVYKVETIGDAYMVV 116
Query: 478 SGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVI 537
G+ P+ T H + FAL+M + +R+G + G V AGV+
Sbjct: 117 CGV-PEK------TDTHAQPVASFALDMVEQAACVMSPATGKPLQIRVGIHTGPVVAGVV 169
Query: 538 GTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSVYVKGKDDM 596
G Y ++GD VN ASRM+S G+P RI + + L + Y + RG +KGK M
Sbjct: 170 GVRMPRYCLFGDTVNTASRMESHGMPGRIHLSPSTFQALEGQGYTCKCRGETLIKGKGCM 229
Query: 597 NVYLLVGKKD 606
Y L+G ++
Sbjct: 230 VTYFLLGDQN 239
>UniRef50_A7RN69 Cluster: Predicted protein; n=2; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 769
Score = 99 bits (238), Expect = 2e-19
Identities = 73/256 (28%), Positives = 134/256 (52%), Gaps = 23/256 (8%)
Query: 357 NREFEISYRLSFYSNVVANRDKQR---VQNMRNQADWLLHNIIPRHVADQLK-NTAKYSE 412
+ +F+ Y L+ ++ ++ +Q + + D LL++++P VA++L+ N +E
Sbjct: 463 SEQFKAEYVLTQQLEILTDKLRQTHNALAEKKQLTDQLLYSVLPPSVANELRHNRPVQAE 522
Query: 413 NHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGS 472
+ V ++F+ I++F ++ S K E + +LN + FD L + P V K++T+G
Sbjct: 523 RAEMVTLLFSGIVDFAQICKNS--KPMEIVMLLNNIYTKFDMLTD-PSINDVYKVETVGD 579
Query: 473 TFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDV 532
+MA SGL P+ R + H + + AL+M+ V + H + ++IG + G+V
Sbjct: 580 KYMAVSGL-PE-----RCAF-HARSICNMALDMKHVTQSIIHKGDKIQ--IKIGIHSGEV 630
Query: 533 TAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL------SARYEFEPRG 586
AGV+G Y ++G+ VN+ SR ++TG P ++ + E L + FE RG
Sbjct: 631 VAGVVGHKTPRYCLFGNTVNLTSRTETTGAPGQVNITEFTYRCLLEPECQDPSFVFERRG 690
Query: 587 SVYVKGKDD-MNVYLL 601
V +KG+ + M YLL
Sbjct: 691 PVAMKGRQEPMVTYLL 706
>UniRef50_A3HVA1 Cluster: Adenylate/guanylate cyclase; n=1;
Algoriphagus sp. PR1|Rep: Adenylate/guanylate cyclase -
Algoriphagus sp. PR1
Length = 464
Score = 99.5 bits (237), Expect = 2e-19
Identities = 75/260 (28%), Positives = 120/260 (46%), Gaps = 24/260 (9%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNM-----RNQADWLLHNIIPRHVADQLKN----T 407
N E E +Y V R++N + +++ LL NI+P A++LK
Sbjct: 219 NEELE-AYNQELEKRVAERTKDLRIKNQELTVEKKRSEDLLLNILPEETAEELKKYGFAK 277
Query: 408 AKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKI 467
AK EN ++F +NF + S + +E + L+ +FD + + +EKI
Sbjct: 278 AKLQEN---ATVMFTDFVNFTKF--SSSISSEELVSELDHCFRNFDAITTK---YRLEKI 329
Query: 468 KTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGY 527
KTIG M+A G+ D + + ++ DF K + F+ +R+G
Sbjct: 330 KTIGDAHMSACGVTGDGGDVADVIRAGI-EMRDFVQSYAKEKPKHLQEYFQ----IRVGI 384
Query: 528 NFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGS 587
N G V AGV+G K +DIWGD VN A R+ S V ++ V E+ + ++FE RG
Sbjct: 385 NTGPVVAGVVGLKKFSFDIWGDTVNTADRIQSGSVAGKVNVSESTYLLTKDLFDFENRGK 444
Query: 588 VYVKGKDDMNVYLLVG-KKD 606
+ K K + +Y + KKD
Sbjct: 445 ISAKNKGMIPMYFVENLKKD 464
>UniRef50_Q2L6K5 Cluster: Guanylate cyclase; n=3; Caenorhabditis|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1073
Score = 99.5 bits (237), Expect = 2e-19
Identities = 69/225 (30%), Positives = 120/225 (53%), Gaps = 18/225 (8%)
Query: 387 QADWLLHNIIPRHVADQLKNTAKYSENHKDVA-IIFASIINFNEMYDESYLKGKEYLRIL 445
+AD LL ++P++VA++LK D+A ++F+ I+ F + S E + +L
Sbjct: 846 RADKLLGQLLPKYVANELKMGRSVPAKTFDMATVMFSDIVGFTTICSSS--TPLEVVSML 903
Query: 446 NELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEM 505
N + + FD+ + + K++TIG +M SG+ P+ G +H+ + + ALE+
Sbjct: 904 NSIYSKFDDAINK---HGSYKVETIGDAYMIVSGI-PE----ENGN-EHIRNICNTALEL 954
Query: 506 QKVVDNFN-HDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQ 564
++ + +R+G + G V AGV+G T Y ++GD VN+ASRM+ST P+
Sbjct: 955 MLLLKTYEIPHRRNVKLRIRLGIHTGTVAAGVVGLTAPRYCLFGDTVNVASRMESTSEPE 1014
Query: 565 RIQVGEA----CVPVLSARYEFEPRGSVYVKGKDDMNVYLLVGKK 605
+IQ+ + CV S ++ RG+V KGK + Y L+GK+
Sbjct: 1015 KIQMSQEARDFCVRYYS-EFQITLRGTVEAKGKGPVTSYWLLGKQ 1058
>UniRef50_A2EEV5 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=3; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1564
Score = 99.5 bits (237), Expect = 2e-19
Identities = 70/227 (30%), Positives = 116/227 (51%), Gaps = 12/227 (5%)
Query: 378 KQRVQNMRNQADWLLHNIIPRHVADQLKN-TAKYSENHKDVAIIFASIINFNEMYDESYL 436
K+ + + +++ LL+ I+PR + ++ N + S + IIF I F+E S L
Sbjct: 1333 KKEAEIEKAKSEKLLYQIMPRDIVVRINNGESDISFSVPFATIIFIDINKFSEY--SSNL 1390
Query: 437 KGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLY 496
++ + L+ A+ D + + ++ + KIK IG +MAA GL H + H
Sbjct: 1391 SPQDIMSNLSFYFAEIDRIASK--YEMLNKIKLIGDIYMAACGLF----HPNIEPIHHAE 1444
Query: 497 QLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF-GDVTAGVIGTTKLYYDIWGDAVNIAS 555
+ FALE+ +DN N L E +RIG N G V AGV+G+ K +DI GD +N+A+
Sbjct: 1445 DTIKFALEVVDEIDNINRCL-ESHLSIRIGVNSSGPVIAGVLGSDKPLFDIIGDPINVAA 1503
Query: 556 RMDSTGVPQRIQVGEACVPVL-SARYEFEPRGSVYVKGKDDMNVYLL 601
R+ STG P ++ V +A +L + G ++KGK Y++
Sbjct: 1504 RLQSTGSPNQVHVSQATYELLKDTDFYISKVGDTFLKGKGVQTTYVV 1550
>UniRef50_Q4SNI3 Cluster: Chromosome 15 SCAF14542, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 15
SCAF14542, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 971
Score = 99.1 bits (236), Expect = 3e-19
Identities = 70/203 (34%), Positives = 104/203 (51%), Gaps = 32/203 (15%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-----KNTAKYSE 412
++ E + RL F V A + ++ +R + +L NI+P HVA N YS+
Sbjct: 577 QQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQ 636
Query: 413 NHKDVAIIFASIINFNEMYDESYL--KGKEYLRILNELIADFDE---------------- 454
++ V ++FASI F + Y ++ + +G E LR+LNE+IADFDE
Sbjct: 637 SYDAVGVMFASIPAFADFYSQTEMNNQGVECLRLLNEIIADFDEVRSKACRGGGTKSFNL 696
Query: 455 -------LLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQK 507
LL +FQ +EKIKTIGST+MA SGL+P+ + + HL L DFA+ + +
Sbjct: 697 SLLSWSQLLGEDRFQDIEKIKTIGSTYMAVSGLSPE-KQQCEDKWGHLCALADFAIALNE 755
Query: 508 VVDNFNHDLFEFDFILRIGYNFG 530
+ N F +F LRIG G
Sbjct: 756 SIQEINKHSFN-NFELRIGEGRG 777
Score = 94.7 bits (225), Expect = 6e-18
Identities = 59/190 (31%), Positives = 97/190 (51%), Gaps = 15/190 (7%)
Query: 394 NIIPRHVADQLKNTAKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFD 453
N+ H+ Q Y +++V+I+FA + F + + L +E +R+LNEL A FD
Sbjct: 105 NVEDEHLQHQFHRI--YIHRYENVSILFADVKGFTNL--STTLPAQELVRMLNELFARFD 160
Query: 454 ELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFN 513
L H +IK +G + SGL P+ R DH + ++ L M K + +
Sbjct: 161 RLAHE---HHCLRIKILGDCYYCVSGL-PEPRQ------DHAHCCVEMGLSMLKTI-RYV 209
Query: 514 HDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACV 573
+ D +RIG + G V GV+G K +D+W V+IA++++S G+P RI + +A +
Sbjct: 210 RSRTKHDIDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKAAL 269
Query: 574 PVLSARYEFE 583
L+ YE E
Sbjct: 270 DCLNGDYEVE 279
Score = 75.4 bits (177), Expect = 4e-12
Identities = 38/64 (59%), Positives = 43/64 (67%), Gaps = 1/64 (1%)
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSV 588
G V AGVIG K YDIWG VN+ASRMDSTGV +IQV E +L R + FE RG +
Sbjct: 812 GSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGKIQVPEETFLILKERGFAFEYRGEI 871
Query: 589 YVKG 592
YVKG
Sbjct: 872 YVKG 875
>UniRef50_A5P476 Cluster: Putative adenylate/guanylate cyclase; n=1;
Methylobacterium sp. 4-46|Rep: Putative
adenylate/guanylate cyclase - Methylobacterium sp. 4-46
Length = 422
Score = 99.1 bits (236), Expect = 3e-19
Identities = 63/226 (27%), Positives = 114/226 (50%), Gaps = 14/226 (6%)
Query: 378 KQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHKD-VAIIFASIINFNEMYDESYL 436
++ +++ R++ D +L +I+P + D++K + + D V I F I+ F + S
Sbjct: 207 ERELRSERDRIDRILRDILPMQIYDRIKGGENHIADLNDHVTISFCDIVGFTHL--ASRT 264
Query: 437 KGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLY 496
+ +R+LN+L + D++ + +EKIKTIG +MAA+G+ D H +
Sbjct: 265 SPHDVIRLLNDLFSQLDDIAAK---HGIEKIKTIGDAYMAAAGVG-DAIHKDA------H 314
Query: 497 QLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASR 556
+ FAL+ ++ V + +R G G V +GVIG T+ +D+WG VN+ASR
Sbjct: 315 AVAGFALDARRAVLETG-ERHGAAIQMRFGIATGQVISGVIGVTRPVFDVWGSTVNLASR 373
Query: 557 MDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLLV 602
+++ P I + +L R+ P G + +KG + + LV
Sbjct: 374 LETASPPGAITLDARTAELLDRRFRVRPSGCIALKGIGAVATFQLV 419
>UniRef50_A2FAE9 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=2; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1576
Score = 98.7 bits (235), Expect = 4e-19
Identities = 68/234 (29%), Positives = 117/234 (50%), Gaps = 11/234 (4%)
Query: 376 RDKQRVQNMRNQADWLLHNIIPRHVADQL-KNTAKYSENHKDVAIIFASIINFNEMYDES 434
+ K+ + + +++ LL+ I+P+ + +L + S I F I+ F+ Y E
Sbjct: 1335 KQKKLAEESKAKSEKLLYQILPKDIVVRLNRGETDISFTIPSATIFFIDIVKFSS-YAE- 1392
Query: 435 YLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDH 494
L E + L+ + A FD ++ +FQ + KIK IG +MAA+GL D + S+ H
Sbjct: 1393 LLTPSEIMANLSLVFATFDGIVS--EFQSITKIKLIGDVYMAAAGLFQDPKEESK---QH 1447
Query: 495 LYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGD-VTAGVIGTTKLYYDIWGDAVNI 553
+ L+ K ++ N L +RIG N G + GV+GT K +DI GD +N+
Sbjct: 1448 AEDAVRCCLKCAKSMEEINMKL-NASLEVRIGCNSGGPLIGGVLGTDKPTFDIIGDTINV 1506
Query: 554 ASRMDSTGVPQRIQVGEACVPVLS-ARYEFEPRGSVYVKGKDDMNVYLLVGKKD 606
A+R+ ST +P +Q+ + ++ + E RG +Y+KGK Y + K +
Sbjct: 1507 AARLQSTDIPGNVQISASTKEMIEHLDFVIEERGLIYLKGKGKQMTYFVSFKNN 1560
>UniRef50_Q07553 Cluster: Guanylate cyclase 32E precursor; n=3;
Diptera|Rep: Guanylate cyclase 32E precursor - Drosophila
melanogaster (Fruit fly)
Length = 1163
Score = 98.7 bits (235), Expect = 4e-19
Identities = 74/225 (32%), Positives = 110/225 (48%), Gaps = 15/225 (6%)
Query: 385 RNQADWLLHNIIPRHVADQLKNTAKYSENHKD-VAIIFASIINFNEMYDESYLKGKEYLR 443
+ + D LL+ ++PR VA+ LK D V I+F+ I+ F E+ S E +
Sbjct: 839 KKKTDMLLYQMLPRPVAELLKRGDPVEAECFDCVTILFSDIVGFTELCTTS--TPFEVVE 896
Query: 444 ILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFAL 503
+LN+ D ++ V K++TIG +M SGL L++ SR H ++ AL
Sbjct: 897 MLNDWYTCCDSIISN---YDVYKVETIGDAYMVVSGL--PLQNGSR----HAGEIASLAL 947
Query: 504 EMQKVVDNFNHDLFEFDFI-LRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGV 562
+ + V N + + LRIG + G AGV+G Y ++GD VN ASRM+STG
Sbjct: 948 HLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGD 1007
Query: 563 PQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDMNVYLLVGKK 605
RI + EA +L Y RG +KGK DM Y L ++
Sbjct: 1008 SMRIHISEATYQLLQVIGSYVCIERGLTSIKGKGDMRTYWLTKRQ 1052
>UniRef50_Q7Q9W6 Cluster: ENSANGP00000003998; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000003998 - Anopheles gambiae
str. PEST
Length = 649
Score = 98.3 bits (234), Expect = 5e-19
Identities = 70/223 (31%), Positives = 111/223 (49%), Gaps = 19/223 (8%)
Query: 385 RNQADWLLHNIIPRHVADQLK---NTAKYSENHKDVAIIFASIINFNEMYDESYLKGKEY 441
+ Q D LL+++IPR +A++L+ N + ++ ++V ++FA + D+S
Sbjct: 436 KRQGDELLYSMIPRSIAERLREGQNPHETCQSFEEVTVLFAEVQE-TITGDDSIKYAMTT 494
Query: 442 LRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDF 501
+ LN + FDEL+ P K++T+G +MA SG PD+ H + D
Sbjct: 495 VNTLNAAFSAFDELIHSPM---AYKVETVGKVYMAVSGA-PDINPF------HAQHMADL 544
Query: 502 ALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTG 561
AL+M + N ++IG++ G + AG++G Y ++GD VN ASRM+S+G
Sbjct: 545 ALDMLHSIRQLNLP----GVGVKIGFHSGPIVAGIVGLKVPRYCLFGDTVNTASRMESSG 600
Query: 562 VPQRIQV-GEACVPVLSARYEFEPRGSVYVKGKDDMNVYLLVG 603
IQV G + Y RG V VKGK DM + L G
Sbjct: 601 ETDCIQVSGYTAQKLKKLGYVLAYRGKVAVKGKGDMETFWLQG 643
>UniRef50_Q174S2 Cluster: Guanylate cyclase; n=7; Coelomata|Rep:
Guanylate cyclase - Aedes aegypti (Yellowfever mosquito)
Length = 1292
Score = 98.3 bits (234), Expect = 5e-19
Identities = 78/249 (31%), Positives = 125/249 (50%), Gaps = 20/249 (8%)
Query: 365 RLSFYSNVVANRDKQRVQNM---RNQADWLLHNIIPRHVADQL-KNTAKYSENHKDVAII 420
R+ Y+N + ++R Q+ + + + LL+ ++PR VA QL + +E + V I
Sbjct: 955 RMEQYANNLEALVEERTQDYFEEKRKCEELLYQLLPRSVAAQLIMGKSVIAETYDQVTIY 1014
Query: 421 FASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL 480
F+ I+ F + +S + + +LN+L FD ++E F V K++TIG +M SGL
Sbjct: 1015 FSDIVGFTSISAQS--TPMQVVDLLNDLYTCFDSIVEN--FD-VYKVETIGDAYMVVSGL 1069
Query: 481 NPDLRHASRGTYDHLYQLMDFALEMQKVVDNFN--HDLFEFDFILRIGYNFGDVTAGVIG 538
+R+ + H ++ AL + V F H E LRIG + G AGV+G
Sbjct: 1070 --PVRNGNL----HAREISRLALALLAAVHKFTIRHRPNE-QLKLRIGLHSGPCVAGVVG 1122
Query: 539 TTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDM 596
Y ++GD VN ASRM+S G P +I + +L +E RG V +KGK +M
Sbjct: 1123 LKMPRYCLFGDTVNTASRMESNGEPLKIHISHTTKTLLDTFGTFEVTERGLVPMKGKGEM 1182
Query: 597 NVYLLVGKK 605
Y L G++
Sbjct: 1183 LTYWLNGER 1191
>UniRef50_A2F2E6 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=3; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1597
Score = 98.3 bits (234), Expect = 5e-19
Identities = 75/243 (30%), Positives = 122/243 (50%), Gaps = 21/243 (8%)
Query: 370 SNVVANRDKQRVQNMRNQADW-------LLHNIIPRHVADQLKNTAK-YSENHKDVAIIF 421
S V+ RD+ + + QAD LL+ I+PR + Q+ K S +I+F
Sbjct: 1319 SFVIMLRDQTVLMEQQKQADAAKATSEKLLYQILPRDIVVQINRGEKNISFTVSSASIVF 1378
Query: 422 ASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL- 480
I+ F++ Y S L +E + L+ D ++ + F + KIK IG +MAA GL
Sbjct: 1379 IDIVKFSD-YSSS-LTPQEIMANLSHYFNTLDTIMAK--FDLLTKIKLIGDIYMAAGGLF 1434
Query: 481 NPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGD-VTAGVIGT 539
NP+L H Q++ F+ E+ ++ N L +R+G N G + AGV+G
Sbjct: 1435 NPELPPQK-----HAEQMVLFSTEVIGELEEINLRL-NCSLSVRVGVNTGGPIIAGVLGK 1488
Query: 540 TKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLS-ARYEFEPRGSVYVKGKDDMNV 598
K +DI GD +NIASR+ ST + +Q+ ++ +++ +PRG V++KGK
Sbjct: 1489 DKPVFDIIGDPINIASRLQSTDIANHVQISQSTYEMINHLNLNVKPRGEVFLKGKGSQMT 1548
Query: 599 YLL 601
YL+
Sbjct: 1549 YLV 1551
>UniRef50_Q9VA09 Cluster: CG1470-PA; n=6; Diptera|Rep: CG1470-PA -
Drosophila melanogaster (Fruit fly)
Length = 787
Score = 97.9 bits (233), Expect = 7e-19
Identities = 72/249 (28%), Positives = 129/249 (51%), Gaps = 21/249 (8%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQ---ADWLLHNIIPRHVADQLKNTAKYSEN 413
+ +FE Y+L+ ++ ++ +Q +++ ++ D LL++++P+ VA++L++
Sbjct: 466 SEKFEAEYKLTKNLEMLTDKLQQTFRDLESEKQKTDRLLYSVLPKSVANELRHQRPVPPK 525
Query: 414 HKD-VAIIFASIINFNEMYDESYLK--GKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
D V ++F+ I+ F + + + +++LNEL FD L + + +V K++T+
Sbjct: 526 RYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNVYKVETV 585
Query: 471 GSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFG 530
G +MA SGL PD H DH + AL+M + N + + IG + G
Sbjct: 586 GDKYMAVSGL-PD--HCE----DHAKCMARVALDMMDMAKNVK--MGSNPVQITIGIHSG 636
Query: 531 DVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGE-----ACVPV-LSARYEFEP 584
+V GVIG Y ++G+ VN+ SR ++TGVP RI V E C+ + + E
Sbjct: 637 EVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEY 696
Query: 585 RGSVYVKGK 593
RG V +KGK
Sbjct: 697 RGPVIMKGK 705
>UniRef50_Q17AS9 Cluster: Adenylate cyclase; n=2; Culicidae|Rep:
Adenylate cyclase - Aedes aegypti (Yellowfever mosquito)
Length = 1154
Score = 97.9 bits (233), Expect = 7e-19
Identities = 53/131 (40%), Positives = 83/131 (63%), Gaps = 7/131 (5%)
Query: 478 SGLNPDLRHASRGTYDHLYQ----LMDFALEMQKVVDNFNHDLFEFDF--ILRIGYNFGD 531
S L+P L H + + H + +FALE+ KV+ +F+ + F+ +LR+G + G
Sbjct: 1003 SDLSPQLPHRNNSSTRHSNNVTIVMTEFALELMKVLRDFSIENFKQTNPGLLRVGISNGK 1062
Query: 532 VTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-SARYEFEPRGSVYV 590
V AGV+G++K YDIWG+AVN+ASRMDSTG+P +IQV + ++ S Y+ E RG ++V
Sbjct: 1063 VMAGVVGSSKPLYDIWGNAVNMASRMDSTGIPGKIQVTKESAEIIQSYGYQCEYRGQIFV 1122
Query: 591 KGKDDMNVYLL 601
KG+ + Y +
Sbjct: 1123 KGRGKIPTYFV 1133
Score = 79.4 bits (187), Expect = 3e-13
Identities = 50/132 (37%), Positives = 75/132 (56%), Gaps = 7/132 (5%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVAD-----QLKNTAKYS 411
+R+ E R+ + + K+ + + L+ NI+P HVA+ QLKN Y+
Sbjct: 837 DRQSEYIARVDYNWKRQLLKQKEEAEVTKQTNKILVENILPTHVAEIYINRQLKNEF-YN 895
Query: 412 ENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLER-PQFQHVEKIKTI 470
E +K+VA++FA+I N + D S K L++LNE+I DFDE L+ + VEKIK
Sbjct: 896 EEYKNVAVMFATITNMDINTDISVENEKSVLKVLNEIICDFDEKLQYFDGYLKVEKIKVA 955
Query: 471 GSTFMAASGLNP 482
G T+MAA GL+P
Sbjct: 956 GWTYMAACGLDP 967
Score = 78.2 bits (184), Expect = 6e-13
Identities = 51/174 (29%), Positives = 88/174 (50%), Gaps = 13/174 (7%)
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
Y + H +V I++A ++N+ + + L K + +L+EL FDE + +F +V +IK
Sbjct: 325 YVQKHTNVTILYADVVNYT--FITTQLPVKSLVDVLHELFVKFDEAAK--EF-NVLRIKF 379
Query: 470 IGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
+G + SG+ +H H +D L M K + + + + +RIG +
Sbjct: 380 LGDCYYCVSGVPIKNKH-------HAKSCVDLGLRMIKDIRDVRMSR-DLNIDMRIGIHS 431
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFE 583
G + +GVIG K YDIW V IA++M+STG ++ V + +L Y +E
Sbjct: 432 GSIISGVIGACKWQYDIWSRDVIIANKMESTGEAGKVHVTMQTLELLDGEYIYE 485
>UniRef50_P92006 Cluster: Soluble guanylate cyclase gcy-34; n=7;
Caenorhabditis|Rep: Soluble guanylate cyclase gcy-34 -
Caenorhabditis elegans
Length = 686
Score = 97.9 bits (233), Expect = 7e-19
Identities = 62/220 (28%), Positives = 114/220 (51%), Gaps = 14/220 (6%)
Query: 385 RNQADWLLHNIIPRHVADQLKNTAKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLRI 444
R + D +L +++PR +A QL + + ++F + F ++ + K +++
Sbjct: 422 RQKTDSILKDMLPRKIAKQLLSGEHLEPCEYEATVMFCDLPAFQQIIP--VCQPKNIVKL 479
Query: 445 LNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALE 504
LNE+ D ++ + V K++T+ ++M SG+ PD + S + + + E
Sbjct: 480 LNEVFFKLDRIVV---LRGVYKVETVSDSYMTVSGI-PD--YTSEHAENMCHVALGMMWE 533
Query: 505 MQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQ 564
+ V+D N + F+LRIG + G + AGV+GT Y ++G+ V +AS+M+S GV
Sbjct: 534 ARSVMDPVN----KTPFLLRIGLHSGTIIAGVVGTKMPRYCLFGETVTLASQMESLGVAG 589
Query: 565 RIQVGE--ACVPVLSARYEFEPRGSVYVKGKDDMNVYLLV 602
+IQ + + R+EF PRG + VKG+ D+ Y L+
Sbjct: 590 KIQCSSWTYSKAMETGRFEFSPRGRINVKGRGDVETYFLM 629
>UniRef50_A2FG49 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=4; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1585
Score = 97.5 bits (232), Expect = 9e-19
Identities = 65/229 (28%), Positives = 113/229 (49%), Gaps = 11/229 (4%)
Query: 376 RDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK-YSENHKDVAIIFASIINFNEMYDES 434
+ +Q + + +++ LL+ I+P+ + +L K S I F I+ F+E +
Sbjct: 1343 KKRQAAEEAKAKSEKLLYQILPKDIVVRLNRGEKDISFTIPSATIFFIDIVKFSEY--AA 1400
Query: 435 YLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDH 494
L E + L+ + A FD ++ +++ + KIK IG +MAA+GL D S H
Sbjct: 1401 LLTPTEIMANLSLVFATFDNIVA--EYESITKIKLIGDVYMAAAGLFQDPEDPS---LKH 1455
Query: 495 LYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGD-VTAGVIGTTKLYYDIWGDAVNI 553
+ + K ++ N L +RIG N G + GV+GT K +DI GD +N+
Sbjct: 1456 AEDAVRCCIACSKAMEEINMKL-NASLEVRIGCNTGGPLLGGVLGTDKPTFDIIGDPINV 1514
Query: 554 ASRMDSTGVPQRIQVGEACVPVL-SARYEFEPRGSVYVKGKDDMNVYLL 601
A+R+ ST +P +Q+ + + +E E RG +Y+KGK + Y +
Sbjct: 1515 AARLQSTDIPGNVQISQDTKEAIKDLDFEVEERGEIYLKGKGNRITYFV 1563
>UniRef50_UPI00015B5A8E Cluster: PREDICTED: similar to
ENSANGP00000003998; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000003998 - Nasonia
vitripennis
Length = 643
Score = 97.1 bits (231), Expect = 1e-18
Identities = 68/221 (30%), Positives = 118/221 (53%), Gaps = 18/221 (8%)
Query: 385 RNQADWLLHNIIPRHVADQLK---NTAKYSENHKDVAIIFASIINFNEMYDESYLKGKEY 441
+N++D LL+++IP+ VAD+L+ + E+ + ++++F + +FN E + +
Sbjct: 402 KNKSDELLYSMIPQSVADRLRAGTSPLDTCESFESISVLFCELCDFNYSTIEGAM---DI 458
Query: 442 LRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDF 501
+ +N + + FD L+++ +V K++T+G +MAASG PD T DH + D
Sbjct: 459 VSSMNAVYSCFDSLMDK---FNVYKVETVGRVYMAASGA-PDR------TDDHAINVADV 508
Query: 502 ALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTG 561
+L++ V + + +RIG + G AGV+G Y +GD VN ASRM +T
Sbjct: 509 SLQLISQVRSLVLPS-GLEIQIRIGIHSGPAVAGVVGIKVPRYCFFGDTVNTASRMQTTS 567
Query: 562 VPQRIQVGEACVPVL-SARYEFEPRGSVYVKGKDDMNVYLL 601
+P ++ + +L RY E RG V VKGK +M + L
Sbjct: 568 LPGKVHISPHTRALLPQDRYVIESRGIVSVKGKGNMETFWL 608
>UniRef50_UPI0000E4A009 Cluster: PREDICTED: similar to soluble
guanylyl cyclase beta-3; n=4; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to soluble guanylyl
cyclase beta-3 - Strongylocentrotus purpuratus
Length = 818
Score = 97.1 bits (231), Expect = 1e-18
Identities = 71/225 (31%), Positives = 112/225 (49%), Gaps = 19/225 (8%)
Query: 387 QADWLLHNIIPRHVADQLKN---TAKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLR 443
+ D LL+ +IPR VA++L+ E V I+F+ ++ F + S + +
Sbjct: 392 RTDSLLYQMIPRQVAEKLRRGEPATSTCEVFTAVTILFSDVVGFTTIC--SRIPPMAVVS 449
Query: 444 ILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFAL 503
+LN + FD L E + V K++TIG +M SG A T H ++ + +L
Sbjct: 450 LLNGMYIKFDNLSETYE---VYKVETIGDAYMVVSG-------APTTTKYHAVRIAEMSL 499
Query: 504 EMQKVVDNFNHDLFEFDFI-LRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGV 562
M++ +++ + + + +R+G + G V AGV+G Y ++GD VN ASRM+STG
Sbjct: 500 AMRESMNDLIDPSSKDEIVKIRVGIHTGMVVAGVVGLKMPRYCLFGDTVNTASRMESTGE 559
Query: 563 PQRIQVGEACVPVL---SARYEFEPRGSVYVKGKDDMNVYLLVGK 604
+I + E L Y+ E RGS VKGK M Y L GK
Sbjct: 560 ALKIHMSETTKKKLDQWEGYYDIEERGSTNVKGKGSMKTYWLHGK 604
>UniRef50_Q4SUW5 Cluster: Chromosome undetermined SCAF13838, whole
genome shotgun sequence; n=2; Tetraodontidae|Rep:
Chromosome undetermined SCAF13838, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 1085
Score = 97.1 bits (231), Expect = 1e-18
Identities = 60/218 (27%), Positives = 111/218 (50%), Gaps = 23/218 (10%)
Query: 377 DKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK----------YSENHKDVAIIFASIIN 426
++ R+++ + + LL +++PR+VA ++K Y + H +V+I+FA I+
Sbjct: 121 ERLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVG 180
Query: 427 FNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRH 486
F + S +E +++LNEL FDEL H +IK +G + SGL
Sbjct: 181 FTSL--ASQCTAQELVKLLNELFGKFDELATE---NHCRRIKILGDCYYCVSGL------ 229
Query: 487 ASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDI 546
++ DH + ++ L+M + + + E D +R+G + G V GV+G K YD+
Sbjct: 230 -TQPKADHAHCCVEMGLDMIDTIASVV-EATEVDLNMRVGLHTGRVLCGVLGLRKWQYDV 287
Query: 547 WGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP 584
W + V +A+ M++ G+P ++ + + L+ YE EP
Sbjct: 288 WSNDVTLANVMEAGGLPGKVHITRTTLECLNGDYEVEP 325
Score = 68.1 bits (159), Expect = 6e-10
Identities = 46/110 (41%), Positives = 56/110 (50%), Gaps = 27/110 (24%)
Query: 522 ILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGE----------- 570
+L G N G V AGVIG + YDIWG+ VN+ASRMDSTGVP +IQV
Sbjct: 944 VLVTGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVPGKIQVSSGFRTHAAPPPA 1003
Query: 571 --------ACVP--------VLSARYEFEPRGSVYVKGKDDMNVYLLVGK 604
A +P +++ RY F RG V VKGK M Y L G+
Sbjct: 1004 PPPALPPLAFLPQVTEDVHRLIAERYRFVCRGQVTVKGKGQMLTYFLEGR 1053
Score = 61.7 bits (143), Expect = 6e-08
Identities = 32/74 (43%), Positives = 48/74 (64%), Gaps = 2/74 (2%)
Query: 454 ELLERPQFQHVEKIKTIGSTFMAASGLNPDL-RHASRGTYDHLYQLMDFALEMQKVVDNF 512
+L++R ++ +EKIKTIGST+MAA GL P A + HL + DFA++M V+D
Sbjct: 848 QLMDRECYRDIEKIKTIGSTYMAAVGLVPTTSAQARKSIAAHLCTVSDFAVDMFDVLDAI 907
Query: 513 NHDLFEFDFILRIG 526
N+ + DF+LR+G
Sbjct: 908 NYQSYN-DFVLRVG 920
>UniRef50_Q9U317 Cluster: Putative uncharacterized protein gcy-25;
n=2; Caenorhabditis|Rep: Putative uncharacterized protein
gcy-25 - Caenorhabditis elegans
Length = 1044
Score = 97.1 bits (231), Expect = 1e-18
Identities = 66/240 (27%), Positives = 123/240 (51%), Gaps = 17/240 (7%)
Query: 372 VVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKN-TAKYSENHKDVAIIFASIINFNEM 430
+VA R ++ Q+M + + LL+ ++P+ VAD +++ E H V ++ + F +
Sbjct: 785 IVAERTRELEQDM-SVTENLLYQLLPKSVADSIRSGKTVVPEQHSSVTLLVVDVCQFTK- 842
Query: 431 YDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRG 490
+ E+++ L L EL + FD ++++ + K++ +G ++ SG+ P++
Sbjct: 843 FCEAFIP-VHILETLQELYSSFDNIVQKNK---AFKVENVGDAYLICSGI-PEM-----S 892
Query: 491 TYDHLYQLMDFALEMQKVVDNFN-HDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGD 549
+ HL ++ +L++Q + F +++G G V AG++G+T + I+GD
Sbjct: 893 GFRHLREICKISLKLQAFMKTFKVRHRPSHTLQIKMGITSGAVAAGILGSTAPRFCIFGD 952
Query: 550 AVNIASRMDSTGVPQRIQVGEACVPVLSARYE---FEPRGSVYVKGKDDMNVYLLVGKKD 606
VN+A RM STG P IQ+ E L ++ E RG + VKGK + L G+KD
Sbjct: 953 TVNMACRMASTGNPGSIQLSELTANTLMEKFPSFMLEERGMIDVKGKGACLTFWLTGEKD 1012
>UniRef50_A2DC46 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=2; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1572
Score = 96.7 bits (230), Expect = 2e-18
Identities = 69/239 (28%), Positives = 119/239 (49%), Gaps = 11/239 (4%)
Query: 366 LSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-KNTAKYSENHKDVAIIFASI 424
LSF + ++ + +++ LL+ I+P+ + +L + S I F I
Sbjct: 1319 LSFTNESEVIEKRKAADIAKAKSEKLLYQILPKDIVVRLNRGETDISFTIPSATIFFIDI 1378
Query: 425 INFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDL 484
+ F+ +Y S L E + L+ + A FD+ + + + + KIK IG +MAA+GL
Sbjct: 1379 VKFS-VYASS-LTPSEIMTNLSTVFAAFDQNVSK--YDLITKIKLIGDVYMAAAGL---F 1431
Query: 485 RHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGD-VTAGVIGTTKLY 543
+ H Q + L+ K +D N +L E +RIG N G + GV+G+ K
Sbjct: 1432 QGEEDDPTKHADQSIKCCLDCIKSMDEINSNL-ESSIEVRIGVNSGGPLIGGVLGSDKPT 1490
Query: 544 YDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSA-RYEFEPRGSVYVKGKDDMNVYLL 601
+DI GD +N+A+R+ ST +P RIQ+ E ++ Y E RG +++KGK + + +
Sbjct: 1491 FDIIGDTINVAARLQSTDIPGRIQISEGTKSLIDGLDYIIEERGEIFLKGKGNRKTFFV 1549
>UniRef50_UPI00006CB402 Cluster: Adenylate and Guanylate cyclase
catalytic domain containing protein; n=1; Tetrahymena
thermophila SB210|Rep: Adenylate and Guanylate cyclase
catalytic domain containing protein - Tetrahymena
thermophila SB210
Length = 2703
Score = 96.3 bits (229), Expect = 2e-18
Identities = 70/221 (31%), Positives = 119/221 (53%), Gaps = 23/221 (10%)
Query: 395 IIPRHVADQL---KNTAKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIAD 451
++PR + ++L +N K S N +VA++F I NF+E+ + + ++ +++L+ L
Sbjct: 1819 LLPRFIREKLYSGQNYDKISTNQGNVAVLFCDITNFDEIMMQ---EEEKIVKVLDNLFRQ 1875
Query: 452 FDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRG-----TY-DHLYQLMDFALEM 505
FD+ + Q V KI+T+G T+MAA+GL + G T+ D + + + A+EM
Sbjct: 1876 FDKSCQANQ---VLKIETVGKTYMAAAGLRDVDEYYQDGQNQVNTFVDPVKRCLQVAMEM 1932
Query: 506 QKVVDNF-----NHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDST 560
Q++ N N+ ++IG N+G V +GVIG K + + GD VN ASR+ ST
Sbjct: 1933 QEIAKNITWGNTNNGGKSGKVEIKIGINYGTVISGVIGFHKPQFSLIGDTVNTASRVCST 1992
Query: 561 GVPQRIQVGEACVP--VLSARYEFEPRGSVYVKGKDDMNVY 599
G+P+ I + + + ++Y FE R V KGK + Y
Sbjct: 1993 GLPKTINISNSSYQKVIQLSQYRFEKR-EVEAKGKGIITTY 2032
Score = 90.6 bits (215), Expect = 1e-16
Identities = 61/224 (27%), Positives = 109/224 (48%), Gaps = 18/224 (8%)
Query: 379 QRVQNMRNQADWLLHNIIPRHVADQ--LKNTAKY--SENHKDVAIIFASIINFNEMYDES 434
Q + Q D L+ ++P+H+ ++ + TA Y +E I+FA I F D++
Sbjct: 2477 QSLNEKNQQTDKLIQYLLPKHILERFLMNPTASYIIAEKFDKQTILFADIAGFTRYSDQN 2536
Query: 435 YLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDH 494
+ + +++L + +FD+ + Q+ V K+ TIG ++ N H +R
Sbjct: 2537 --QPETVVKMLRTIFTEFDQ---KCQYHKVFKVYTIGDCYVILGNTN----HENRDPPTE 2587
Query: 495 LYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIA 554
Y ++ A +M +++ +L E +RIG + G + G++GT + YDI+G V IA
Sbjct: 2588 AYNVIMMAFQMIEILKRTT-ELVENQIDMRIGVHTGKIVGGLVGTQIVRYDIYGVDVMIA 2646
Query: 555 SRMDSTGVPQRIQVGEACVPVLSARYE----FEPRGSVYVKGKD 594
++M+S G + V E +L RY F +G VY+K D
Sbjct: 2647 NKMESNGQKGSVVVSETTKDILQERYGKEFIFTEKGDVYIKATD 2690
>UniRef50_A2E7P5 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1457
Score = 96.3 bits (229), Expect = 2e-18
Identities = 73/226 (32%), Positives = 113/226 (50%), Gaps = 14/226 (6%)
Query: 378 KQRVQNMRNQADWLLHNIIPRHVADQLKNTAK-YSENHKDVAIIFASIINFNEMYDESYL 436
K+ + + +++ LL+ I+PR + QL K S IIF I F+E + L
Sbjct: 1223 KKAAEEAKAKSEKLLYQILPRDIVVQLNRGEKDISFVVPSATIIFIDINKFSEY--AANL 1280
Query: 437 KGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL-NPDLRHASRGTYDHL 495
++ + L+ A D+L + + KIK IG +MAA+GL N D S H
Sbjct: 1281 SPQDIMANLSYYFACIDKLAAKHTM--ITKIKLIGDIYMAAAGLFNLDSPPES-----HA 1333
Query: 496 YQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGD-VTAGVIGTTKLYYDIWGDAVNIA 554
Q++ FA+E ++D N L + +RIG N G V AGV+GT K +DI GD +N+A
Sbjct: 1334 EQVIQFAIECVSILDEVNIKL-DASLQIRIGINTGGPVIAGVLGTDKPAFDIIGDPINVA 1392
Query: 555 SRMDSTGVPQRIQVGEACVPVL-SARYEFEPRGSVYVKGKDDMNVY 599
+R+ ST I + +A ++ + YE RG ++KGK Y
Sbjct: 1393 ARLQSTDEVNHIHISQATFDLIRGSNYEVTQRGETFLKGKGKQMTY 1438
>UniRef50_A0CQM4 Cluster: Chromosome undetermined scaffold_24, whole
genome shotgun sequence; n=5; Oligohymenophorea|Rep:
Chromosome undetermined scaffold_24, whole genome shotgun
sequence - Paramecium tetraurelia
Length = 2488
Score = 96.3 bits (229), Expect = 2e-18
Identities = 67/210 (31%), Positives = 112/210 (53%), Gaps = 13/210 (6%)
Query: 395 IIPRHVADQL-KNTAKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFD 453
++PR + +++ K + SE+ DVAI+F I +F+++ +K E+L + L FD
Sbjct: 1549 LMPRFIKERMSKGQIQISEDQGDVAILFCDIYDFDDIIRNEQIKVVEFL---DNLYRQFD 1605
Query: 454 ELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFN 513
+ + + Q KI+T+G T+MAA GL + + +++D AL+MQ+ V
Sbjct: 1606 QFCQANELQ---KIETVGKTYMAAGGLKD---YNMSDNLNPTERILDAALQMQESVKTMK 1659
Query: 514 HDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVG-EAC 572
+ + IL+IG ++G V AGVIG K + + GD VN SR+ ST P I + +A
Sbjct: 1660 YG-DKKAVILKIGIHYGRVIAGVIGAHKPQFSLIGDTVNTTSRVCSTSEPGIITLSQQAY 1718
Query: 573 VPVLSARYEFEPRGSVYVKGKDDMNVYLLV 602
V + +Y+F+ R V KGK + Y +
Sbjct: 1719 EKVSNKKYQFKLR-EVEAKGKGTIKTYQFI 1747
Score = 72.1 bits (169), Expect = 4e-11
Identities = 51/181 (28%), Positives = 93/181 (51%), Gaps = 9/181 (4%)
Query: 391 LLHNIIPRHVADQLKNTAKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIA 450
L +II R + + T +++ ++ I+FA I F + Y S ++ ++ + +L L
Sbjct: 2271 LPQHIIGRFFSTDITTTDNFTDVFENCTILFADIAGFTK-YSSS-VEPEQVVNMLRILFQ 2328
Query: 451 DFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVD 510
FDE ++ FQ V K+ TIG ++ ++ + +R ++ F L+M +++
Sbjct: 2329 QFDEACQK--FQ-VYKLYTIGDCYVCMGIIDAN----NRDPVGEAINVVLFGLKMIQIIQ 2381
Query: 511 NFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGE 570
N D +RIG + G V GV+GT + YDI+G+ V A++M+S G +I V +
Sbjct: 2382 QINKDPQFQHLNMRIGAHTGRVIGGVVGTDVVRYDIYGEDVTTANKMESKGQEGKIMVSQ 2441
Query: 571 A 571
A
Sbjct: 2442 A 2442
>UniRef50_Q9GYQ4 Cluster: Guanylyl cyclase protein 8; n=3;
Caenorhabditis|Rep: Guanylyl cyclase protein 8 -
Caenorhabditis elegans
Length = 1206
Score = 95.9 bits (228), Expect = 3e-18
Identities = 66/231 (28%), Positives = 112/231 (48%), Gaps = 18/231 (7%)
Query: 381 VQNMRNQADWLLHNIIPRHVADQLK-NTAKYSENHKDVAIIFASIINFNEMYDESYLKGK 439
++ +AD LL ++P +VA++LK + ++F+ I+ F EM +
Sbjct: 943 LEEANQRADRLLSQLLPAYVANELKLGRPVPPKTFTSSTVLFSDIVGFTEMCQNA--SPL 1000
Query: 440 EYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLM 499
E + +LN + FD+ + R + K++TIG +M SG+ + H H+ ++
Sbjct: 1001 EVVAVLNGIFDGFDQFIAR---KDAYKVETIGDAYMVVSGVPEENGHR------HINEIA 1051
Query: 500 DFALEMQKVVDNF--NHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRM 557
AL++ K + F H + R+G++ G V A V+G Y ++GD VN+ASRM
Sbjct: 1052 SIALDVHKFLSEFIVPHKR-DTKVQCRLGFHTGPVAAAVVGLNAPRYCLFGDTVNMASRM 1110
Query: 558 DSTGVPQRIQVGEACVPVLSARYE---FEPRGSVYVKGKDDMNVYLLVGKK 605
+S P + Q+ E +L Y E RG + +KGK Y L+G K
Sbjct: 1111 ESNSEPGKTQISETAKNLLLKEYPDYICEQRGEIPIKGKGLCMTYWLMGTK 1161
>UniRef50_Q2L6K7 Cluster: Recepotor type guanyly cyclase; n=1;
Caenorhabditis elegans|Rep: Recepotor type guanyly
cyclase - Caenorhabditis elegans
Length = 1152
Score = 95.9 bits (228), Expect = 3e-18
Identities = 66/231 (28%), Positives = 112/231 (48%), Gaps = 18/231 (7%)
Query: 381 VQNMRNQADWLLHNIIPRHVADQLK-NTAKYSENHKDVAIIFASIINFNEMYDESYLKGK 439
++ +AD LL ++P +VA++LK + ++F+ I+ F EM +
Sbjct: 889 LEEANQRADRLLSQLLPAYVANELKLGRPVPPKTFTSSTVLFSDIVGFTEMCQNA--SPL 946
Query: 440 EYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLM 499
E + +LN + FD+ + R + K++TIG +M SG+ + H H+ ++
Sbjct: 947 EVVAVLNGIFDGFDQFIAR---KDAYKVETIGDAYMVVSGVPEENGHR------HINEIA 997
Query: 500 DFALEMQKVVDNF--NHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRM 557
AL++ K + F H + R+G++ G V A V+G Y ++GD VN+ASRM
Sbjct: 998 SIALDVHKFLSEFIVPHKR-DTKVQCRLGFHTGPVAAAVVGLNAPRYCLFGDTVNMASRM 1056
Query: 558 DSTGVPQRIQVGEACVPVLSARYE---FEPRGSVYVKGKDDMNVYLLVGKK 605
+S P + Q+ E +L Y E RG + +KGK Y L+G K
Sbjct: 1057 ESNSEPGKTQISETAKNLLLKEYPDYICEQRGEIPIKGKGLCMTYWLMGTK 1107
>UniRef50_A2FW09 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=12; Eukaryota|Rep: Adenylate
and Guanylate cyclase catalytic domain containing protein
- Trichomonas vaginalis G3
Length = 1567
Score = 95.9 bits (228), Expect = 3e-18
Identities = 64/227 (28%), Positives = 114/227 (50%), Gaps = 12/227 (5%)
Query: 378 KQRVQNMRNQADWLLHNIIPRHVADQLKN-TAKYSENHKDVAIIFASIINFNEMYDESYL 436
++ + + +++ LL+ I+P+++ +L S I F I+ F+ S L
Sbjct: 1330 RKEAEEAKAKSEKLLYQILPKNIVVRLNGGETDISFTINSATIFFIDIVKFSNY--ASLL 1387
Query: 437 KGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLY 496
E + L+ + A FD ++ + + + KIK IG +MAA+GL + + H
Sbjct: 1388 TPSEIMSNLSLVFATFDSIVSK--YTTITKIKLIGDVYMAAAGLFMEEDSPQK----HAE 1441
Query: 497 QLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGD-VTAGVIGTTKLYYDIWGDAVNIAS 555
+ + LE K +D+ N+ L +RIG N G + GV+GT K +DI GD +N+A+
Sbjct: 1442 EAVRCCLECSKSMDDINYKL-NASLEVRIGCNSGGPLIGGVLGTDKPTFDIIGDPINVAA 1500
Query: 556 RMDSTGVPQRIQV-GEACVPVLSARYEFEPRGSVYVKGKDDMNVYLL 601
R+ ST +P +Q+ G + + + E RG +Y+KGK + Y +
Sbjct: 1501 RLQSTDIPGNVQISGNTKELIQNLDFVIEERGEIYLKGKGNRMTYFV 1547
>UniRef50_Q8TA72 Cluster: Guanylate cyclase; n=2; Eumetazoa|Rep:
Guanylate cyclase - Asterias amurensis (Starfish)
Length = 1067
Score = 95.5 bits (227), Expect = 4e-18
Identities = 76/231 (32%), Positives = 110/231 (47%), Gaps = 17/231 (7%)
Query: 379 QRVQNMRNQADWLLHNIIPRHVADQL-KNTAKYSENHKDVAIIFASIINFNEMYDESYLK 437
Q +Q + + + LLH ++P +A QL K + E V I F+ I+ F + S
Sbjct: 833 QELQKEKAKTEQLLHRMLPPSIASQLIKGISVAPEAFDMVTIFFSDIVGFTALSAAS--T 890
Query: 438 GKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQ 497
+ + +LN L FD + V K++TIG +M SGL LR+ +R H
Sbjct: 891 PIQVVNLLNALYTTFDATISN---YDVYKVETIGDAYMLVSGL--PLRNGNR----HAGM 941
Query: 498 LMDFALEMQKVVDNF--NHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIAS 555
+ A + + V F H E LRIG + G AGV+G T Y ++GD VN AS
Sbjct: 942 IASAAWHLLEEVTTFVVPHKRDE-KLKLRIGIHSGSCVAGVVGLTMPRYCLFGDTVNTAS 1000
Query: 556 RMDSTGVPQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDMNVYLLVGK 604
RM+S G+ +I V C VL Y RG V +KGK ++ Y L G+
Sbjct: 1001 RMESNGLALKIHVSPECRQVLQELGGYNLVERGLVAMKGKGEILTYWLEGQ 1051
>UniRef50_Q19187 Cluster: Guanylate cyclase; n=3; Bilateria|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1280
Score = 95.1 bits (226), Expect = 5e-18
Identities = 73/230 (31%), Positives = 113/230 (49%), Gaps = 17/230 (7%)
Query: 381 VQNMRNQADWLLHNIIPRHVADQL-KNTAKYSENHKDVAIIFASIINFNEMYDESYLKGK 439
+++ + ++ LL ++P VA+QL E V I F+ I+ F + ES
Sbjct: 989 LKDEQRRSQHLLQRMLPSSVAEQLLAGQDVIPEAFPPVTIYFSDIVGFTTISGES--TPM 1046
Query: 440 EYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLM 499
E + LN+L FD ++ R V K++TIG +M SG+ P + H Q+
Sbjct: 1047 EVVTFLNKLYTLFDSIIRR---YDVYKVETIGDAYMVVSGV-PQYKTMEY----HAEQIA 1098
Query: 500 DFALEMQKVVDNFN--HDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRM 557
A+ + V +F+ H E ++RIG + G AGV+G T Y ++GD VN ASRM
Sbjct: 1099 MMAIHILSAVRSFSIPHRSCE-PLMIRIGMHTGPCVAGVVGKTMPRYTLFGDTVNTASRM 1157
Query: 558 DSTGVPQRIQVGEACVPVLSA---RYEFEPRGSVYVKGKDDMNVYLLVGK 604
+S G RI + VL++ + E RGS+ +KGK M Y L G+
Sbjct: 1158 ESNGEALRIHCSSSTQKVLTSIDQGFLLEERGSLAIKGKGQMTTYWLNGR 1207
>UniRef50_O97053 Cluster: Guanylate cyclase; n=1; Stichopus
japonicus|Rep: Guanylate cyclase - Stichopus japonicus
(Sea cucumber)
Length = 1075
Score = 95.1 bits (226), Expect = 5e-18
Identities = 69/224 (30%), Positives = 115/224 (51%), Gaps = 15/224 (6%)
Query: 385 RNQADWLLHNIIPRHVADQLKNTAKYS-ENHKDVAIIFASIINFNEMYDESYLKGKEYLR 443
+ +A+ LL+ I+P+ VA++LK + E + V I F+ I+ F ++ +S + +
Sbjct: 846 KKKAEELLYQILPKPVAEELKKGKPVTAETFEVVTIYFSDIVGFTKLSSQS--TPLQVVD 903
Query: 444 ILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFAL 503
+LN+L FD +++ +V K++TIG +M SGL +R+ G Y H ++ +L
Sbjct: 904 LLNDLYTAFDAVIDN---FNVYKVETIGDAYMVVSGL--PIRN---GDY-HAREIARMSL 954
Query: 504 EMQKVVDNFN-HDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGV 562
+ + + F E LRIG + G AGV+G Y ++GD VN ASRM+S G
Sbjct: 955 ALLQRIKTFRIRHRSEERLKLRIGIHSGPAVAGVVGLKMPRYCLFGDTVNTASRMESNGE 1014
Query: 563 PQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDMNVYLLVGK 604
+I V + +L + E RG + +KGK Y L G+
Sbjct: 1015 ALKIHVSSSTKKILDLFGTFVLEKRGEIEMKGKGVQTTYWLQGE 1058
>UniRef50_A2DDF2 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1498
Score = 95.1 bits (226), Expect = 5e-18
Identities = 63/219 (28%), Positives = 117/219 (53%), Gaps = 11/219 (5%)
Query: 387 QADWLLHNIIPRHVADQLKNTAK-YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRIL 445
+++ LL+ I+P+ + +L K S I F I+ F+ + L E + L
Sbjct: 1265 KSEKLLYQILPKDIVVRLNRGEKDISFTIPKATIFFVDIVKFSNY--AAALSPSEIMSNL 1322
Query: 446 NELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEM 505
+ + + FD+++ + + + KIK IG +MAA+G+ D + + + ++ L++
Sbjct: 1323 SLVFSTFDKIVVK--YPTILKIKLIGDVYMAAAGIFSDPQMNPSKPAE---ESVNCCLDI 1377
Query: 506 QKVVDNFNHDLFEFDFILRIGYNFGD-VTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQ 564
QKV++ N L +RIG N G + GV+GT K +DI GD +N+ASR+ ST +P
Sbjct: 1378 QKVMEQINVKL-SAGLEVRIGVNTGGPLIGGVLGTDKPTFDIIGDPINVASRLQSTDIPG 1436
Query: 565 RIQVGEACVPVLS-ARYEFEPRGSVYVKGKDDMNVYLLV 602
++Q+ + +++ + + E RG VY+KGK + Y ++
Sbjct: 1437 KVQISQETKEMIAGSNFVIEERGEVYLKGKGNRTTYFVM 1475
>UniRef50_Q238W6 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Tetrahymena thermophila
SB210|Rep: Adenylate and Guanylate cyclase catalytic
domain containing protein - Tetrahymena thermophila SB210
Length = 2814
Score = 94.7 bits (225), Expect = 6e-18
Identities = 65/232 (28%), Positives = 123/232 (53%), Gaps = 16/232 (6%)
Query: 375 NRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKY--SENHKDVAIIFASIINFNEMYD 432
+++K R+++ + + +L ++P+ V D++ NT + +EN +VA++F I +F+ +
Sbjct: 1724 SQNKLRIESAK--INNILAILLPKFVRDRISNTGEIQLAENQGEVAVLFCDICDFDNILQ 1781
Query: 433 ESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGT- 491
+ ++ + +L+ L +FD L + KI+T+G T++AASGL+ +L++ + T
Sbjct: 1782 S---ESEKIVALLDNLFRNFDILCSQ---NDCTKIETVGKTYVAASGLSLELQNKKKHTV 1835
Query: 492 YDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAV 551
Y+ + +L++ +MQ V N + ++IG ++G V AGVIG K + + GD +
Sbjct: 1836 YNSVERLINLGFDMQDYVKNISWGKHGDKMRVKIGIHYGRVMAGVIGYHKPQFSLIGDTI 1895
Query: 552 NIASRMDSTGVPQRIQVGEACVPVLS----ARYEFEPRGSVYVKGKDDMNVY 599
N SR+ STG R+ + + + Y R V KGK M Y
Sbjct: 1896 NTTSRVMSTGEDNRMTISSQAYAKIQTHNLSNYRTN-RKEVEAKGKGVMVTY 1946
Score = 74.9 bits (176), Expect = 6e-12
Identities = 60/241 (24%), Positives = 116/241 (48%), Gaps = 17/241 (7%)
Query: 362 ISYR-LSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYS-----ENHK 415
+SY+ L F + + + + + + +L N++P+HV ++ N + + +N +
Sbjct: 2389 LSYQYLLFKLYIKTFNNHKNLSKKTKEQNQILSNLLPKHVLEKFLNNPETTRLELVDNFE 2448
Query: 416 DVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFM 475
DV I+FA I F + S + ++ + +L +L +FD+ + + + K+ TIG ++
Sbjct: 2449 DVTILFADIAGFTKY--SSQVDPEQVVNMLKKLFYEFDKACQENE---IFKLYTIGDCYV 2503
Query: 476 AASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAG 535
G D+R R + +++ M +++ + +RIG + G + G
Sbjct: 2504 VI-GFT-DIR--KRNPAEEAKNVLNMGFNMIEIIKQLRAQVKFESLDMRIGVHTGKIIGG 2559
Query: 536 VIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL--SARYEFEPRGSVYVKGK 593
VIGT + YDI+G V IA++M+S+G RI V +L S ++F V +K
Sbjct: 2560 VIGTDIVRYDIYGRDVVIANKMESSGEQGRILVSSQTRKLLEPSGIFDFVDDKEVKIKSI 2619
Query: 594 D 594
D
Sbjct: 2620 D 2620
>UniRef50_Q73RD3 Cluster: Adenylate/guanylate cyclase catalytic domain
protein; n=1; Treponema denticola|Rep:
Adenylate/guanylate cyclase catalytic domain protein -
Treponema denticola
Length = 1075
Score = 94.3 bits (224), Expect = 8e-18
Identities = 62/233 (26%), Positives = 114/233 (48%), Gaps = 16/233 (6%)
Query: 362 ISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-KNTAKYSENHKDVAII 420
+ +R V + K+ + + + ++D LL N +P + D+L K + + V ++
Sbjct: 788 LQHRAQELDKKVKEKTKE-LADEKEKSDKLLKNTLPLSIIDELIKMGESKPKLYPAVTVL 846
Query: 421 FASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL 480
FA ++ F E + + LN L FD +++ E+IKT+G ++A SGL
Sbjct: 847 FADVVGFTEW--SGHNTPDAVISGLNSLFTHFDGIMD---LYGCERIKTLGDGYLACSGL 901
Query: 481 NPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTT 540
+ HA R ++D A+ M + ++ FN + + F ++IG + G +T G++G
Sbjct: 902 TNEKNHAER--------VVDAAVAMLRSLETFNKEN-DSCFSIKIGISSGAITGGIVGVH 952
Query: 541 KLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGK 593
K +D++GD VN A R++S P V E+ ++ +Y R +KGK
Sbjct: 953 KYIFDVFGDTVNTAFRLESVTSPTACTVSESTAALIRGKYGLHKRPDQNLKGK 1005
>UniRef50_A2FWD6 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=3; cellular organisms|Rep:
Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1591
Score = 94.3 bits (224), Expect = 8e-18
Identities = 68/227 (29%), Positives = 114/227 (50%), Gaps = 12/227 (5%)
Query: 378 KQRVQNMRNQADWLLHNIIPRHVADQLKNTAK-YSENHKDVAIIFASIINFNEMYDESYL 436
K++ + + +++ LL+ I+PR V QL K S IIF I F+E + L
Sbjct: 1337 KKQAEEAKAKSEKLLYQILPRDVVVQLNKGEKDISFVVPSATIIFIDINKFSEY--SANL 1394
Query: 437 KGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLY 496
++ + LN A D++ + + ++KIK IG +MAA+GL + H
Sbjct: 1395 TPQDIMANLNHYFACIDKIAAK--YNMLQKIKLIGDIYMAAAGLF----NTDSPAEQHAE 1448
Query: 497 QLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGD-VTAGVIGTTKLYYDIWGDAVNIAS 555
Q + F L++ +D N L + + +R+G N G V AGV+GT K +DI GD +N+A+
Sbjct: 1449 QTILFGLDVVATMDEINLKL-DANLQIRVGINSGGPVIAGVLGTDKPVFDIIGDPINVAA 1507
Query: 556 RMDSTGVPQRIQVGEACVP-VLSARYEFEPRGSVYVKGKDDMNVYLL 601
R+ ST R+ + +A V + ++ RG ++KGK Y +
Sbjct: 1508 RLQSTCEVNRVHISQATFDLVKGSNFDVVQRGETFLKGKGKQITYYI 1554
>UniRef50_O75343 Cluster: Guanylate cyclase soluble subunit beta-2;
n=32; Euteleostomi|Rep: Guanylate cyclase soluble
subunit beta-2 - Homo sapiens (Human)
Length = 617
Score = 94.3 bits (224), Expect = 8e-18
Identities = 60/220 (27%), Positives = 109/220 (49%), Gaps = 14/220 (6%)
Query: 385 RNQADWLLHNIIPRHVADQLKNTAKYSENH-KDVAIIFASIINFNEMYDESYLKGKEYLR 443
+ + + LL+ ++P+HVA+QL+ K + K I+F+ ++ F + + + + +
Sbjct: 357 KKKTETLLYAMLPKHVANQLREGKKVAAGEFKSCTILFSDVVTFTNIC--TACEPIQIVN 414
Query: 444 ILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFAL 503
+LN + + FD L V K++TIG +M G+ + + H ++ +FAL
Sbjct: 415 VLNSMYSKFDRLTS---VHAVYKVETIGDAYMVVGGVPVPIGN-------HAQRVANFAL 464
Query: 504 EMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVP 563
M+ + + LR+G + G V A V+G Y ++GD VN ASRM+S G+P
Sbjct: 465 GMRISAKEVTNPVTGEPIQLRVGIHTGPVLADVVGDKMPRYCLFGDTVNTASRMESHGLP 524
Query: 564 QRIQVGEACVPVLSAR-YEFEPRGSVYVKGKDDMNVYLLV 602
++ + L + ++ RG + VKGK M Y L+
Sbjct: 525 NKVHLSPTAYRALKNQGFKIIERGEIEVKGKGRMTTYFLI 564
>UniRef50_Q2L6K6 Cluster: Guanylate cyclase; n=3; Caenorhabditis|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1113
Score = 93.9 bits (223), Expect = 1e-17
Identities = 68/220 (30%), Positives = 110/220 (50%), Gaps = 16/220 (7%)
Query: 387 QADWLLHNIIPRHVADQLKNTAKYSEN-HKDVAIIFASIINFNEMYDESYLKGKEYLRIL 445
+AD LL ++P +VA++LK + + I+F+ I+ F + S E + +L
Sbjct: 886 RADQLLTQLLPAYVANELKMGRSVAPKLYSSATILFSDIVGFTTICSGS--TPLEVVNML 943
Query: 446 NELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEM 505
N L FDE + R + K++TIG +M SG+ P+ Y+H + + AL+M
Sbjct: 944 NGLYTGFDECITRNKSY---KVETIGDAYMVVSGI-PE-----ENEYNHSRNIANTALDM 994
Query: 506 QKVVDNFNHDLFEFDFI-LRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQ 564
++ + + + R G++ G V AGV+G T Y ++GD VN++SRM+STG P
Sbjct: 995 RQYLTGYQIPHRPTHRVRCRWGFHTGSVAAGVVGLTCPRYCLFGDTVNVSSRMESTGTPG 1054
Query: 565 RIQVGEACVPVLSAR---YEFEPRGSVYVKGKDDMNVYLL 601
IQ+ E + A + RG V VKGK + L
Sbjct: 1055 MIQMSEEAHMHIRAHHPVFTTTERGEVQVKGKGTCRTFWL 1094
>UniRef50_UPI00006CB3C2 Cluster: Adenylate and Guanylate cyclase
catalytic domain containing protein; n=1; Tetrahymena
thermophila SB210|Rep: Adenylate and Guanylate cyclase
catalytic domain containing protein - Tetrahymena
thermophila SB210
Length = 2982
Score = 93.5 bits (222), Expect = 1e-17
Identities = 61/221 (27%), Positives = 114/221 (51%), Gaps = 16/221 (7%)
Query: 391 LLHNIIPRHVADQLKNTA-----KYSENHKDVAIIFASIINFNEMYDESYLKGKEYLRIL 445
+L ++P+ + +++K+ ++ E + +IIF I +F+++ E K ++ + L
Sbjct: 1860 VLEILLPKFIINRIKSNDPNKPFRFQEKQGEASIIFCDICHFDDIIKE---KNEKIIPFL 1916
Query: 446 NELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNP--DLRHASRGTYDHLYQLMDFAL 503
+++ +FD+ R Q ++KI+T+G T+MA++GL D + D + + + AL
Sbjct: 1917 DKVFKNFDQFCAR---QGLQKIETVGKTYMASAGLKDFEDQVDIRQREIDPVERAANLAL 1973
Query: 504 EMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVP 563
EM V + + L+IG ++G V AGVIG K + + GD VN SR+ S G P
Sbjct: 1974 EMLDYVKDLKWSQNGKNLELKIGIHYGQVIAGVIGHHKPQFSLIGDTVNTTSRVCSKGNP 2033
Query: 564 QRIQVGEACVPVLSAR---YEFEPRGSVYVKGKDDMNVYLL 601
+ + E + + + F +V+ KGK D+ +Y L
Sbjct: 2034 SEVTISEQAFEKIQGKTNQFFFSDPKTVFAKGKGDITLYTL 2074
Score = 67.7 bits (158), Expect = 8e-10
Identities = 52/218 (23%), Positives = 106/218 (48%), Gaps = 15/218 (6%)
Query: 369 YSNVVANRDKQRVQNMRNQA-DWLLHNIIPRHVAD--QLKNTAKYS---ENHKDVAIIFA 422
+S V N + R+ + + Q D L+ N+IP+H+ D +K+ A+ + + ++ ++FA
Sbjct: 2668 FSLQVQNYNTMRILDAKKQQKDNLVRNLIPKHLLDYFNVKSIAQQTDLCDVFEEATLLFA 2727
Query: 423 SIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNP 482
I +F + S +E + +L+ L FD + Q K+ TIG ++ N
Sbjct: 2728 DITDFTKYC--SMRNPEEVVNMLSNLFLKFD---MKCQELKCFKVYTIGDCYVVLGVDNA 2782
Query: 483 DLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKL 542
R+ ++ ++ L M +++ ++ +RIG + G + G+ G+ +
Sbjct: 2783 KERNPAK----EANNVVQMGLNMLEIIKQVRSEVNFETLNMRIGIHTGQIIGGITGSDIV 2838
Query: 543 YYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARY 580
YDI+G V ++++M+S G P +I V + +L + Y
Sbjct: 2839 RYDIYGTDVMLSNKMESNGEPGKIMVSQTTKDLLESAY 2876
>UniRef50_UPI0000586B0F Cluster: PREDICTED: similar to receptor type
guanylyl cyclase; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to receptor type
guanylyl cyclase - Strongylocentrotus purpuratus
Length = 688
Score = 93.1 bits (221), Expect = 2e-17
Identities = 68/199 (34%), Positives = 106/199 (53%), Gaps = 16/199 (8%)
Query: 385 RNQADWLLHNIIPRHVADQLK-NTAKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLR 443
R +AD LL+ ++PR VADQLK + +E ++ V I F+ I+ F + + + +
Sbjct: 402 RKRADRLLYQMLPRCVADQLKMGLSVAAEQYEHVTIYFSDIVGFTSL--AAACSPLQVVN 459
Query: 444 ILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFAL 503
+LN L + FD +++ +V K++TIG +M SGL PD T H +++ AL
Sbjct: 460 MLNGLYSMFDGCIDK---YNVYKVETIGDAYMVVSGL-PD------ATDRHAWEISTMAL 509
Query: 504 EMQKVVDNFN-HDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGV 562
E++ +V F + + LRIG + G AGV+G Y ++GD VN ASRM+S+G
Sbjct: 510 ELRSLVMGFKVPHMNDATLRLRIGIHSGSCVAGVVGLKMPRYCLFGDTVNTASRMESSGE 569
Query: 563 PQRI--QVGEACVPVLSAR 579
+ I V P LS R
Sbjct: 570 ARSITPSVPGTSQPALSNR 588
>UniRef50_Q9GT37 Cluster: Guanylate cyclase; n=2; Heterodera
glycines|Rep: Guanylate cyclase - Heterodera glycines
(Soybean cyst nematode worm)
Length = 1174
Score = 93.1 bits (221), Expect = 2e-17
Identities = 67/232 (28%), Positives = 115/232 (49%), Gaps = 18/232 (7%)
Query: 379 QRVQNMRNQADWLLHNIIPRHVADQLK-NTAKYSENHKDVAIIFASIINFNEMYDESYLK 437
+ ++ + ++D LL+ ++PR VA+ LK + E + V + F+ I+ F + ++ ++
Sbjct: 912 RELEEEKRKSDILLYRMMPRQVANSLKLGQSVEPEQFECVTVFFSDIVQFAALSNQ--MR 969
Query: 438 GKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQ 497
+ ++NEL FD +++ V K+++IG ++ SGL +R H Q
Sbjct: 970 PLHVVNLMNELYTTFDAIVDE---HDVYKVESIGDGYLCVSGL------PNRNGNLHAKQ 1020
Query: 498 LMDFALEMQKVVDNFNHDLFEFDFI-LRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASR 556
D AL+ + +F I LRIG + G AGV+G Y ++GD VN ASR
Sbjct: 1021 CADMALKFLNSLQSFRISEHSDQRIRLRIGLHSGPCVAGVVGLAMPRYCLFGDTVNTASR 1080
Query: 557 MDSTGVPQRIQVG-EACVPV----LSARYEFEPRGSVYVKGKDDMNVYLLVG 603
M+S+ +I + E C+ + Y E RG V +KGK M + L+G
Sbjct: 1081 MESSSSANKIHISKETCILLHENSEGGAYLTESRGEVIIKGKGVMETFWLLG 1132
>UniRef50_A7S7B3 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 918
Score = 93.1 bits (221), Expect = 2e-17
Identities = 70/244 (28%), Positives = 124/244 (50%), Gaps = 24/244 (9%)
Query: 376 RDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSEN--HKD-VAIIFASIINFNEMYD 432
++ +RV+ R +++ LL+ +IP+ +AD+LK + H D V I+F+ + F ++
Sbjct: 666 KNMKRVERERMRSNQLLYQMIPKQIADRLKEGQDAIDTCQHFDCVTILFSYLDGFVQLC- 724
Query: 433 ESYLKGKEYLRILNELIADFDELLERPQFQH-------VEKIKTIGST-FMAASGLN-PD 483
S++ E + ++N + FD+L E+ + K +T+G +MA SG P
Sbjct: 725 -SHVSAMEVVSVVNTMFTVFDKLSEKHDVYKAFDLHCSILKFETLGDAIYMAVSGAPVPK 783
Query: 484 LRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLY 543
RHA + AL+M +D + IG + G V AGV+G
Sbjct: 784 ARHAE--------PMAAMALDMIDAMDEIKKFCSNALLTITIGMHSGAVVAGVVGKRTPQ 835
Query: 544 YDIWGDAVNIASRMDSTGVPQRIQVGEACVP-VLSARYEFEPRGSVYVKG-KDDMNVYLL 601
Y ++G VNIASR+ +T +P RI + +C +L+ + E RG++ +KG + +M Y L
Sbjct: 836 YCLFGHTVNIASRLRTTALPMRIHISNSCNECLLNTEFHTEFRGTILLKGIQGEMKTYWL 895
Query: 602 VGKK 605
+G++
Sbjct: 896 IGRE 899
>UniRef50_Q4BYX5 Cluster: Guanylate cyclase:Histidine kinase, HAMP
region; n=4; Chroococcales|Rep: Guanylate
cyclase:Histidine kinase, HAMP region - Crocosphaera
watsonii
Length = 318
Score = 92.7 bits (220), Expect = 3e-17
Identities = 72/247 (29%), Positives = 125/247 (50%), Gaps = 23/247 (9%)
Query: 364 YRLSFYSNVVA---NRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKY-SENHKDVAI 419
Y+L+ N +A + +K+ ++ Q D LL +P + +LK K ++ V +
Sbjct: 76 YQLATAFNKMARTIDEEKEALEEQIRQNDSLLLKTLPAPIVKRLKEGEKQIADKFPHVTV 135
Query: 420 IFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASG 479
+ A+I+ F+E + + ++ + ILN++I FD+ +R VEKI T+G++++AASG
Sbjct: 136 LSANIVGFDEECE--LMSAEKAVGILNDIITAFDDAAQR---HDVEKISTVGTSYLAASG 190
Query: 480 LN-PDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIG 538
L P L D +++ ALEM ++V F+ + + F +RIG G+V G++G
Sbjct: 191 LFVPRL--------DRDKAVIELALEMLRIVRAFSQERHHY-FEIRIGIYSGEVIGGLLG 241
Query: 539 TTKLYYDIWGDAVNIASRM----DSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKD 594
K Y++ G+ IA + G P I V + L Y+F G + V G+
Sbjct: 242 KQKFIYNLMGNTAKIARFLMIVNSVEGKPNSILVSQNLYEPLQEFYQFSKMGEIDVPGQG 301
Query: 595 DMNVYLL 601
M V+LL
Sbjct: 302 KMAVWLL 308
>UniRef50_Q9XZS0 Cluster: Guanylyl cyclase; n=4; cellular
organisms|Rep: Guanylyl cyclase - Dictyostelium
discoideum (Slime mold)
Length = 1486
Score = 92.7 bits (220), Expect = 3e-17
Identities = 59/218 (27%), Positives = 111/218 (50%), Gaps = 13/218 (5%)
Query: 385 RNQADWLLHNIIPRHVADQLKNTAKYS-ENHKDVAIIFASIINFNEMYDESYLKGKEYLR 443
+ + + L+ I+P + +K+ + + K+V I + I+ F EM + + ++ +
Sbjct: 1137 QRETESLVAEILPADIVKSMKSGRQLIVDEFKNVTIFLSDIVGFTEM--AARMSPRQLVE 1194
Query: 444 ILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFAL 503
LN++ + FDE+ + +F V KI TIG + SG PD + DH +++ + A+
Sbjct: 1195 TLNQIYSTFDEIAQ--EFG-VLKIATIGDAYFCVSGC-PD-----KDQTDHAFRVANMAI 1245
Query: 504 EMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVP 563
+M + + + + +RIG + G V AGV+G ++Y +WG++V I +M+ST
Sbjct: 1246 KMLESIKSIR-TVDNIPIRMRIGIHTGPVIAGVVGIKMIHYQLWGESVQITQQMESTSRA 1304
Query: 564 QRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYLL 601
I V E +L ++Y FE R +K + +LL
Sbjct: 1305 DMIHVSEDTFNILKSKYLFEERPDGIIKKRKIKTYFLL 1342
Score = 89.0 bits (211), Expect = 3e-16
Identities = 60/194 (30%), Positives = 98/194 (50%), Gaps = 18/194 (9%)
Query: 412 ENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIG 471
+++ V ++F I+NFN + ++ + + + +LNE+ FD L + V K++ IG
Sbjct: 389 DSYDPVTVLFCEIVNFNALVEK--MSSTQVINLLNEVYNSFDRLTD---VYGVTKVEHIG 443
Query: 472 STFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGD 531
+ +M G P+L DH ++ +L M V+ F + + +RIG + G
Sbjct: 444 NVYMVVGGC-PEL------CPDHAQRVAHMSLGMLSVIRRFG--IVQ----VRIGMHTGP 490
Query: 532 VTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVK 591
V G+IG KL + ++GD +N +SRM S RIQV +L + FE RG + VK
Sbjct: 491 VVGGIIGKKKLSWHLFGDTINTSSRMASHSSIGRIQVSHPVQQLLRPYFLFEDRGKIQVK 550
Query: 592 GKDDMNVYLLVGKK 605
GK M + LV K
Sbjct: 551 GKGLMRTFYLVKTK 564
>UniRef50_Q02153 Cluster: Guanylate cyclase soluble subunit beta-1;
n=40; Coelomata|Rep: Guanylate cyclase soluble subunit
beta-1 - Homo sapiens (Human)
Length = 619
Score = 92.7 bits (220), Expect = 3e-17
Identities = 72/263 (27%), Positives = 136/263 (51%), Gaps = 25/263 (9%)
Query: 359 EFEISYRLSFYSNVVANRDK---QRVQNMRNQADWLLHNIIPRHVADQLKNTAKY-SENH 414
+F Y+L+ ++ +R + + +++ + + D LL++++P VA++L++ ++ +
Sbjct: 358 QFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRY 417
Query: 415 KDVAIIFASIINFNEMYDESYLKGKEYLRI---LNELIADFDELLERPQFQHVEKIKTIG 471
+V I+F+ I+ FN + + G+ ++I LN+L FD L + + V K++T+G
Sbjct: 418 DNVTILFSGIVGFNA-FCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVG 476
Query: 472 STFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGD 531
+M SGL H +R +M+ A ++Q VD + + IG + G+
Sbjct: 477 DKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQ--VDGESVQI-------TIGIHTGE 527
Query: 532 VTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSA------RYEFEPR 585
V GVIG Y ++G+ VN+ SR ++TG +I V E L + ++ E R
Sbjct: 528 VVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHR 587
Query: 586 GSVYVKG-KDDMNVYLLVGKKDT 607
G V +KG K+ M V+ L +K+T
Sbjct: 588 GPVSMKGKKEPMQVWFL-SRKNT 609
>UniRef50_UPI00006CF863 Cluster: Adenylate and Guanylate cyclase
catalytic domain containing protein; n=1; Tetrahymena
thermophila SB210|Rep: Adenylate and Guanylate cyclase
catalytic domain containing protein - Tetrahymena
thermophila SB210
Length = 1213
Score = 92.3 bits (219), Expect = 3e-17
Identities = 65/219 (29%), Positives = 114/219 (52%), Gaps = 11/219 (5%)
Query: 391 LLHNIIPRHVADQL-KN-TAKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNEL 448
+L ++P+ + D++ KN + E+ +V+I+F I +F ++ + +R++++L
Sbjct: 213 VLSILMPKFIRDKIDKNGEVQLQEDQGEVSILFCDICDFEQILSAEQ---ENIVRLVDKL 269
Query: 449 IADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASR-GTYDHLYQLMDFALEMQK 507
FD L Q KI+T+G T+MAA GL S+ + + + + + EM
Sbjct: 270 FRSFDSLCNHAGLQ---KIETVGKTYMAAGGLKDSENKKSQYKQINPVARAVIMSFEMMD 326
Query: 508 VVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQ 567
++ FN+ E ++IG ++G V AGVIG K + + GD VN ASR+ STG +I
Sbjct: 327 IIKQFNYGDNE-KVKIKIGIHYGRVIAGVIGCHKPQFSLIGDTVNTASRVCSTGDVGQIT 385
Query: 568 VGE-ACVPVLSARYEFEPRGSVYVKGKDDMNVYLLVGKK 605
+ E A + Y + VY KGK D+N Y ++ ++
Sbjct: 386 LSEQAYDEIKQIPYIIFQKKRVYAKGKGDINTYQVMKRQ 424
Score = 68.9 bits (161), Expect = 4e-10
Identities = 53/223 (23%), Positives = 108/223 (48%), Gaps = 18/223 (8%)
Query: 378 KQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYS----ENHKDVAIIFASIINFNEMYDE 433
+Q +++ + + +L ++P H+ + N + +V +FA I F + Y
Sbjct: 984 RQTLESRAKKQNDILMYLLPEHILSKFLNNPNKKIDLIDQLDNVTFLFADIAGFTK-YSG 1042
Query: 434 SYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYD 493
S ++ + + +L L +FD+ ++ +++ KI TIG ++ N R ++
Sbjct: 1043 S-VQPENVVNMLRILFNEFDQQCQK---KNLYKIYTIGDCYVVIGTKNASNRLRP---HE 1095
Query: 494 HLYQLMDFALEMQKVVDNFNHDLFEFDFI-LRIGYNFGDVTAGVIGTTKLYYDIWGDAVN 552
+++ EM +++ + +F+ + +RIG + G GVIGT + YDI+G V
Sbjct: 1096 EAKNVVELGFEMIEIIKKVR-SIVQFEELEMRIGVHTGSYIGGVIGTDIVRYDIYGPDVM 1154
Query: 553 IASRMDSTGVPQRIQVGEACVPVL----SARYEFEPRGSVYVK 591
IA++M+S G ++ V + + +L +RY F VY+K
Sbjct: 1155 IANKMESNGEQGKVMVSKTTMNLLYDHYGSRYNFTKGNEVYIK 1197
>UniRef50_UPI00006CB738 Cluster: Adenylate and Guanylate cyclase
catalytic domain containing protein; n=1; Tetrahymena
thermophila SB210|Rep: Adenylate and Guanylate cyclase
catalytic domain containing protein - Tetrahymena
thermophila SB210
Length = 2700
Score = 92.3 bits (219), Expect = 3e-17
Identities = 68/234 (29%), Positives = 124/234 (52%), Gaps = 23/234 (9%)
Query: 378 KQRVQNMRNQADWLLHNIIPRHVADQLKNTAKY--SENHKDVAIIFASIINFNEMYDESY 435
+Q ++ + + D LL ++P+ V ++L N+ K+ +++ +VAI+FA + + +E+ ++
Sbjct: 1902 QQTIKIQKTENDNLLSILVPKFVQNKL-NSGKFEMADDQDEVAILFADVCDMDEIMEK-- 1958
Query: 436 LKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASG-------LNPDLRHAS 488
+G + ++++L FD + E+ +KI+T+G T+MAA+G L+ +L+
Sbjct: 1959 -EGNNIVYLIDDLFRAFDFICEK---HGAQKIETVGKTYMAATGIIECEVDLDNNLKQKG 2014
Query: 489 RGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWG 548
+G +L++ A EM V N + F L+IG N G V AGVIG K + + G
Sbjct: 2015 KGV-----RLLNMAKEMIDVAQNKKYGNGYKSFCLKIGINKGKVMAGVIGNPKPQFSLIG 2069
Query: 549 DAVNIASRMDSTGVPQRIQVGEAC-VPVLSARYEFEPRGSVYVKGKDDMNVYLL 601
D VN SR+ + P I V E+ V S +++ P KGK ++ Y +
Sbjct: 2070 DTVNTTSRICAESKPNEILVSESIKEEVKSMKFKLVPH-KFTPKGKAELCAYFI 2122
Score = 84.6 bits (200), Expect = 7e-15
Identities = 57/238 (23%), Positives = 115/238 (48%), Gaps = 16/238 (6%)
Query: 380 RVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENH------KDVAIIFASIINFNEMYDE 433
++ + +N+ L+ ++P ++++N +S+ DV ++FA I F E D+
Sbjct: 2466 KISSKKNRMKELVDQLLPAVALNKMRNQGNFSDKKGLTDCFDDVTVLFADIKGFTEFSDK 2525
Query: 434 SYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYD 493
+ K+ L +L L FD L + Q V K+ TIG ++ S + + + +
Sbjct: 2526 -VVDPKKVLLMLKNLFESFDGLCVKHQ---VFKLYTIGDCYVVLSFITAERQDTIAEKIE 2581
Query: 494 HLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNI 553
++++ L+M + ++ + F +RIG + G + G++GT + YD++G V I
Sbjct: 2582 EAKKVINMGLDMIETINIIKGTAYPF-LNMRIGIHTGKIIGGIMGTDVVRYDVYGKDVMI 2640
Query: 554 ASRMDSTGVPQRIQVGEACVPVLSA----RYEFEPRGSVYVKGKDD-MNVYLLVGKKD 606
A++M+S G P ++ + E+ +L Y V VKG+++ + Y + K D
Sbjct: 2641 ANKMESNGEPGKVMISESTKQMLEKGEVNEYNITEGNEVSVKGRNEPIKGYFITKKTD 2698
>UniRef50_A0EAN1 Cluster: Chromosome undetermined scaffold_86, whole
genome shotgun sequence; n=2; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_86, whole genome shotgun
sequence - Paramecium tetraurelia
Length = 2476
Score = 91.9 bits (218), Expect = 5e-17
Identities = 59/210 (28%), Positives = 113/210 (53%), Gaps = 13/210 (6%)
Query: 395 IIPRHVADQLKNTAKYS--ENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADF 452
++P+ + + + + ++ EN +VAI+F I F+ + ++ + + +L+ L +
Sbjct: 1674 LMPKFIRNMINQSGEFDIQENQGEVAILFCDICEFDTIIK---VQQQNVVHLLDILFRQY 1730
Query: 453 DELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNF 512
D L + +++KI+T+G T+MAASGL + S+ + +++ + A EMQK +
Sbjct: 1731 DSLCNQ---YNLQKIETVGKTYMAASGLKNLI---SQNNINPVFRALQVAFEMQKFASSQ 1784
Query: 513 NHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEAC 572
+ E + +++IG ++G+V AGVIG K + + GD VN SR+ ST +I++ E
Sbjct: 1785 SFGQTE-NIVVKIGVHYGNVIAGVIGYHKPQFSLIGDTVNTTSRVCSTAQDNQIKISEEA 1843
Query: 573 VPVLSARYEFE-PRGSVYVKGKDDMNVYLL 601
+S+ +F V KGK + YL+
Sbjct: 1844 YKQVSSCVDFTFTLDIVEAKGKGQLTTYLV 1873
Score = 86.6 bits (205), Expect = 2e-15
Identities = 63/230 (27%), Positives = 112/230 (48%), Gaps = 15/230 (6%)
Query: 368 FYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL----KNTAKYSENHKDVAIIFAS 423
F NV A K +++ Q D L+ + +P H+ DQ ++ A + H+DV ++FA
Sbjct: 2227 FLKNVEAYNQKCKLKYKHEQLDQLVKHQLPTHMLDQFLQLQQSRAVLKDQHEDVTLLFAD 2286
Query: 424 IINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPD 483
I F E S + ++ + +L L +FD+ + ++V K+ TIG ++ ++
Sbjct: 2287 IAGFTEY--SSKVAPEQVVFMLRNLFTEFDKCCQE---KNVYKLYTIGDCYVVMGMVDAK 2341
Query: 484 LRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLY 543
R+ + + + + ++KV D N+ D +RIG + G + GV+GT +
Sbjct: 2342 DRNPALEAKNTVEMAFEMINIIRKVRDKINNS----DLHMRIGIHTGKIIGGVLGTDIVR 2397
Query: 544 YDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARY--EFEPRGSVYVK 591
YDI+G V IA++M+S ++QV E L Y EF+ + VK
Sbjct: 2398 YDIYGPDVLIANKMESKSERGQVQVSETTKKTLELCYPEEFQYQSHCMVK 2447
>UniRef50_Q86C56 Cluster: Soluble guanylate cyclase gcy-31; n=4;
Caenorhabditis|Rep: Soluble guanylate cyclase gcy-31 -
Caenorhabditis elegans
Length = 702
Score = 91.9 bits (218), Expect = 5e-17
Identities = 64/232 (27%), Positives = 113/232 (48%), Gaps = 18/232 (7%)
Query: 380 RVQNMRNQADWLLHNIIPRHVADQLK---NTAKYSENHKDVAIIFASIINFNEMYDESYL 436
R++ R + D LL+ ++P+ VA+QL+ + E V I+F I+ F +M S L
Sbjct: 394 RLKKERRRTDKLLYQMLPKSVANQLRHGESAVACCERFDSVTILFTDIVEFTKMC--SSL 451
Query: 437 KGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLY 496
E + L + +FD++++ V K++TIG +M SG H + D
Sbjct: 452 TPLEVIEFLKVIYTNFDKIIDT---HGVYKVETIGDAYMVVSGAPTKTEHDAEFILDCAS 508
Query: 497 QLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASR 556
Q F +E K+V N N+ + + D +R G + G V AGV+G + Y ++G+ V +A++
Sbjct: 509 Q---FLVEAGKMV-NMNNKIHKID--IRAGVHSGSVVAGVVGLSMPRYCLFGETVYVANK 562
Query: 557 MDSTGVPQRIQVGEACVPVLS----ARYEFEPRGSVYVKGKDDMNVYLLVGK 604
M+ P +I V E + Y+FE R + +K + + +V +
Sbjct: 563 MEQNSSPMKILVSETTHNKIEESDPGLYQFERREEIEIKDDQTIQTFFVVSR 614
>UniRef50_A7SJA1 Cluster: Predicted protein; n=4; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 520
Score = 91.1 bits (216), Expect = 8e-17
Identities = 63/193 (32%), Positives = 103/193 (53%), Gaps = 14/193 (7%)
Query: 372 VVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKY-SENHKDVAIIFASIINFNEM 430
+V R +Q + + + + D LL+ ++PR++A+ LK +E++ V I F+ I+ F E+
Sbjct: 339 IVDERTRQ-LADEKAKTDELLYKMLPRYIAESLKRGEPVIAESYSSVTIFFSDIVGFTEL 397
Query: 431 YDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRG 490
S + + +LN+L FD ++++ V K++TIG +M SGL +R+ R
Sbjct: 398 AAAS--TPLQVVDLLNDLYTCFDTIIDK---HDVYKVETIGDAYMVVSGL--PVRNGHR- 449
Query: 491 TYDHLYQLMDFALEMQKVVDNFN-HDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGD 549
H ++ AL + + NF L LRIG + G AGV+G Y ++GD
Sbjct: 450 ---HAGEIATMALNLLSSMGNFRARHLPNRPIHLRIGIHTGSCVAGVVGLKMPRYCLFGD 506
Query: 550 AVNIASRMDSTGV 562
VN ASRM+STGV
Sbjct: 507 TVNYASRMESTGV 519
>UniRef50_A0CKZ5 Cluster: Chromosome undetermined scaffold_20, whole
genome shotgun sequence; n=4; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_20, whole genome shotgun
sequence - Paramecium tetraurelia
Length = 2620
Score = 91.1 bits (216), Expect = 8e-17
Identities = 65/228 (28%), Positives = 120/228 (52%), Gaps = 11/228 (4%)
Query: 378 KQRVQNMRNQADWLLHNIIPRHVADQL-KNTAKYSENHKDVAIIFASIINFNEMYDESYL 436
+ R+ + + + +L ++PR + +++ K + S++ DV+++F I F+++ +
Sbjct: 1611 QNRLSKEQKKINSVLGLLMPRFIQERMNKGQIQISQDQGDVSVLFCDIYQFDKVIKDQQE 1670
Query: 437 KGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLY 496
K E+L + + FD+L + Q KI+T+G T+MAA GL ++ +
Sbjct: 1671 KIIEFL---DTIYRAFDQLCQNYDLQ---KIETVGKTYMAAGGLKDYDVVINQKNANSTS 1724
Query: 497 QLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASR 556
+ ++ A++M + V + + D L+IG ++G V AGVIG K + + GD VN SR
Sbjct: 1725 RALETAIQMMETVKTMKYGDNQ-DVQLKIGIHYGRVIAGVIGVHKPQFSLIGDTVNTTSR 1783
Query: 557 MDSTGVPQRIQVGEACVPVL--SARYEFEPRGSVYVKGKDDMNVYLLV 602
+ STG I + EA + + +Y+FE + SV KGK + Y L+
Sbjct: 1784 VCSTGEAGFITLSEAAYLHVKDNTKYQFEKK-SVAAKGKGMIETYKLI 1830
Score = 70.5 bits (165), Expect = 1e-10
Identities = 53/212 (25%), Positives = 106/212 (50%), Gaps = 17/212 (8%)
Query: 391 LLHNIIPRHVADQL-----KNTAKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLRIL 445
+L ++P H +L +NT + + ++ ++FA I F + Y S ++ + + +L
Sbjct: 2399 MLQYLMPPHALRRLLNPDQENTDTFMDVLENATVLFADIAGFTK-YSSS-VEPETVVDML 2456
Query: 446 NELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEM 505
L ++FD+ ++ + + K+ TIG ++ L+ R + +++ F M
Sbjct: 2457 RNLFSNFDQYCQKAE---IYKLFTIGDCYVCMGVLDCKKRDPA----GEAQKVLAFGFSM 2509
Query: 506 QKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQR 565
++++++ D +RIG + G V GV+GT + YDI+G+ V IA+ M+S+G +
Sbjct: 2510 IEIINHYKKDPQYQHLNMRIGVHTGRVLGGVVGTDVVRYDIYGEDVTIANLMESSGQEGK 2569
Query: 566 IQVGEACVPVLSARYE---FEPRGSVYVKGKD 594
I V E ++ YE F+ VY+ K+
Sbjct: 2570 ILVSEITKNLVENEYEGFQFDYAKDVYLPSKN 2601
>UniRef50_Q23496 Cluster: Guanylate cyclase; n=2; Caenorhabditis|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1118
Score = 90.6 bits (215), Expect = 1e-16
Identities = 72/247 (29%), Positives = 125/247 (50%), Gaps = 24/247 (9%)
Query: 371 NVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLK-NTAKYSENHKDVAIIFASIINFNE 429
N+V +R ++ + QAD LL++++P+ +A+ LK + + ++F+ I F
Sbjct: 875 NMVRDRTAL-LEEAQKQADRLLNSMLPKSIAEDLKIGKPVLPQLYSCATVLFSDIRGFTR 933
Query: 430 MYDESY------LKGKEYL-RILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNP 482
+ S L+ K + LN++ + FD ++ + K++TIG +M SG+
Sbjct: 934 ISSTSTPLQVCKLRQKIIVVTFLNDMFSGFDAIIAK---HDAYKVETIGDAYMIVSGVPT 990
Query: 483 DLRHASRGTYDHLYQLMDFALEMQKVVDNFN--HDLFEFDFILRIGYNFGDVTAGVIGTT 540
+ ++ H + D AL+M+ + NF H E ++RIG++ G V AGV+G
Sbjct: 991 ENGNS------HAQNIADVALKMRAFICNFKLAHRPEEL-MMVRIGFHSGPVAAGVVGLA 1043
Query: 541 KLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKDDMNVYL 600
Y ++GD VN ASRM+STGV +IQ+ E +L F P+ + +GK ++ V
Sbjct: 1044 APRYCLFGDTVNTASRMESTGVANKIQISEGAYNLLHC---FFPQFQMVERGKIEVKVSE 1100
Query: 601 LVGKKDT 607
KK T
Sbjct: 1101 KSEKKAT 1107
>UniRef50_A2F3K7 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1588
Score = 90.6 bits (215), Expect = 1e-16
Identities = 67/228 (29%), Positives = 116/228 (50%), Gaps = 14/228 (6%)
Query: 378 KQRVQNMRNQADWLLHNIIPRHVADQL-KNTAKYSENHKDVAIIFASIINFNEMYDESYL 436
K++ +N + +++ LL+ I+PR + Q+ KN + S N I F I F+E + L
Sbjct: 1350 KRQAENEKMKSENLLYQILPRDIVLQINKNIKEISFNVNSATICFIDINKFSEY--TTNL 1407
Query: 437 KGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL-NPDLRHASRGTYDHL 495
+ L+ + D+ L+ ++ + KIK IG +MAA G+ N D+ G H
Sbjct: 1408 TPNNIMSNLSYYFSVLDQTLK--EYPLLIKIKLIGDIYMAAGGIFNNDV-----GPEVHA 1460
Query: 496 YQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGD-VTAGVIGTTKLYYDIWGDAVNIA 554
Q++ F ++ ++ N L + + +RIG N G + AGV+GT K +DI GD +N+A
Sbjct: 1461 EQMILFCFDVLYHLEEINKKL-DSNLQIRIGINTGGPLIAGVLGTDKPLFDIIGDPINVA 1519
Query: 555 SRMDSTGVPQRIQV-GEACVPVLSARYEFEPRGSVYVKGKDDMNVYLL 601
+R+ ST ++ + G+ V Y+ RG ++KGK Y +
Sbjct: 1520 ARLQSTSDVNKVHISGDTFELVKGLNYDITKRGETFLKGKGKQITYYI 1567
>UniRef50_UPI0000E47581 Cluster: PREDICTED: similar to natriuretic
peptide receptor A; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to natriuretic peptide
receptor A - Strongylocentrotus purpuratus
Length = 1008
Score = 90.2 bits (214), Expect = 1e-16
Identities = 70/222 (31%), Positives = 107/222 (48%), Gaps = 15/222 (6%)
Query: 385 RNQADWLLHNIIPRHVADQLKN-TAKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLR 443
+ +++ LL+ ++PR VADQLK A ++ I F+ I+ F + +S + +
Sbjct: 794 KKRSETLLYEVLPRSVADQLKRGEAVNPTSYDSTTIYFSDIVGFTTLSADS--TPMQVVT 851
Query: 444 ILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFAL 503
+LN+L FDE++ V KIKT+ +M SGL G H ++ +L
Sbjct: 852 LLNDLYTCFDEIIGN---YDVYKIKTVCDAYMVVSGLP-----IGNGNL-HAREISAMSL 902
Query: 504 EMQKVVDNFN-HDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGV 562
+ K V F E LR+G + G AGV+G Y ++GD VN ASRM+STG
Sbjct: 903 ALIKEVSTFRISHRPEEKLKLRVGIHSGPCVAGVVGLKMPRYCLFGDTVNTASRMESTGE 962
Query: 563 PQRIQVGEACVPVLSARYEFEP--RGSVYVKGKDDMNVYLLV 602
+I + E +L F+ RG V +KGK Y L+
Sbjct: 963 AMKIHLSEKTKLILEEFQCFQTILRGRVELKGKGSYLTYWLL 1004
>UniRef50_A2FID0 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=7; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1568
Score = 89.8 bits (213), Expect = 2e-16
Identities = 65/227 (28%), Positives = 114/227 (50%), Gaps = 14/227 (6%)
Query: 379 QRVQNMRNQADWLLHNIIPRHVADQLKNTAK-YSENHKDVAIIFASIINFNEMYDESYLK 437
++ + + +++ LL+ I+PR + QL K + IIF I+ F+E Y + L
Sbjct: 1336 KQAEEAKAKSEKLLYQILPRDIVVQLNRGEKDITFTVNSATIIFIDIVRFSE-YTVN-LS 1393
Query: 438 GKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL-NPDLRHASRGTYDHLY 496
++ ++ L+ A D++ + + V KIK IG +MAA+GL NP+ S H
Sbjct: 1394 PQDIMQNLSLYFAGIDKIASK--YNMVTKIKLIGDIYMAAAGLFNPETSPES-----HAE 1446
Query: 497 QLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGD-VTAGVIGTTKLYYDIWGDAVNIAS 555
Q + L+ +D N L + +R+G N G + AGV+GT K +DI GD +N+A+
Sbjct: 1447 QAVMLGLDSIAELDEINMRL-DSSLTIRVGVNSGGPIIAGVLGTDKPAFDIIGDPINVAA 1505
Query: 556 RMDSTGVPQRIQVGEACVPVLSA-RYEFEPRGSVYVKGKDDMNVYLL 601
R+ ST + + +A ++ ++ R ++KGK YL+
Sbjct: 1506 RLQSTDEANHVHISQATYDLIKGMSFDIAARVETFLKGKGKQMTYLV 1552
>UniRef50_A2EN44 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=3; Eukaryota|Rep: Adenylate
and Guanylate cyclase catalytic domain containing protein
- Trichomonas vaginalis G3
Length = 1574
Score = 89.8 bits (213), Expect = 2e-16
Identities = 71/229 (31%), Positives = 112/229 (48%), Gaps = 17/229 (7%)
Query: 379 QRVQNMRNQADWLLHNIIPRHVADQL-KNTAKYSENHKDVAIIFASIINFNEMYDESYLK 437
++ ++ + +++ LL+ I+PR + +Q+ + S N +IIF I F+E Y
Sbjct: 1339 KQAEDEKKKSEKLLYQILPRDIVNQINRGENDISFNVSTCSIIFIDINKFSE-----YAA 1393
Query: 438 GKEYLRILNELIADFDELLERP-QFQHVEKIKTIGSTFMAASGLNP--DLRHASRGTYDH 494
I+ L F L + ++ + KIK IG +M ASGL P D+ + S H
Sbjct: 1394 NLTPSMIMTNLSFYFSVLDKTAAKYPLLTKIKLIGDIYMGASGLFPTEDMTNES-----H 1448
Query: 495 LYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGD-VTAGVIGTTKLYYDIWGDAVNI 553
Q FAL++ +D N L + +R+G N G + AGV+GT K +DI GD +N+
Sbjct: 1449 AEQTCLFALDVMYQMDEINKRL-DTSLGIRVGINTGGPIIAGVLGTDKPLFDIIGDPINV 1507
Query: 554 ASRMDSTGVPQRIQVG-EACVPVLSARYEFEPRGSVYVKGKDDMNVYLL 601
ASR+ ST I V E V S ++ PRG +KGK + +
Sbjct: 1508 ASRLQSTSAVNHIHVSKETAELVKSMNFDVIPRGQTALKGKGTQQTFYI 1556
>UniRef50_Q4TAT8 Cluster: Guanylate cyclase; n=2; Tetraodontidae|Rep:
Guanylate cyclase - Tetraodon nigroviridis (Green puffer)
Length = 1154
Score = 89.4 bits (212), Expect = 2e-16
Identities = 73/247 (29%), Positives = 127/247 (51%), Gaps = 22/247 (8%)
Query: 366 LSFYSNVVANRDKQRVQNM---RNQADWLLHNIIPRHVADQLKNTAKYS-ENHKDVAIIF 421
L YS+ + + ++R + R + D L+ ++P+ VA LK E++ + + F
Sbjct: 888 LEQYSSNLEDLIRERTDELEVERTKTDKLVGQLLPKSVAQALKKGRPVQPEHYSESTLYF 947
Query: 422 ASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLN 481
+ I+ F + + + E + +LN+L FD ++ V K++TIG +M ASG+
Sbjct: 948 SDIVGFTTI--SALSEPIEVVDLLNDLYTMFDAIIAT---HDVYKVETIGDAYMVASGV- 1001
Query: 482 PDLRHASRGTYDHLYQLMDFALEMQKVVDNFN-HDLFEFDFILRIGYNFGDVTAGVIGTT 540
P+ R+ +R H ++ + +L++ + F + E +RIG + G V AGV+G T
Sbjct: 1002 PN-RNGNR----HAAEVANMSLDILHSIAAFKIKHMPEIKVKIRIGLHSGPVVAGVVGLT 1056
Query: 541 KLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSA---RYEFEPRGSVYVKGKDDMN 597
Y ++GD V AS M+++G+P RI + + V VL++ Y E R VKG D
Sbjct: 1057 MPRYCLFGDTVTTASHMEASGLPYRIHISLSTVKVLTSLKLGYHMETR-KAQVKGAVD-- 1113
Query: 598 VYLLVGK 604
Y LVG+
Sbjct: 1114 TYWLVGR 1120
>UniRef50_Q4S9A3 Cluster: Chromosome undetermined SCAF14699, whole
genome shotgun sequence; n=3; Euteleostomi|Rep:
Chromosome undetermined SCAF14699, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 1292
Score = 89.0 bits (211), Expect = 3e-16
Identities = 45/86 (52%), Positives = 56/86 (65%), Gaps = 1/86 (1%)
Query: 487 ASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDI 546
+ R + HL L DFAL M+ + N N+ F +F+LRIG N G V AGVIG K +YDI
Sbjct: 1122 SDRERWQHLADLADFALAMKVTLMNINYQSFN-NFMLRIGLNKGGVLAGVIGARKPHYDI 1180
Query: 547 WGDAVNIASRMDSTGVPQRIQVGEAC 572
WG+ VN+ASRM+STGV IQV C
Sbjct: 1181 WGNTVNVASRMESTGVMGNIQVCPGC 1206
Score = 81.4 bits (192), Expect = 6e-14
Identities = 50/174 (28%), Positives = 90/174 (51%), Gaps = 16/174 (9%)
Query: 417 VAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLE-RPQFQ-----HVEKIKTI 470
V+I+FA I+ F ++ S +E +++LNEL A FD+L P + H +IK +
Sbjct: 342 VSILFADIVGFTQL--SSSCSAQELVKLLNELFARFDKLAAVSPDSRSHSKYHQLRIKIL 399
Query: 471 GSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFG 530
G + GL PD R DH + L M + + ++ + + D +R+G + G
Sbjct: 400 GDCYYCICGL-PDYRE------DHAACSIMMGLAMVEAI-SYVREKTQTDVDMRVGVHSG 451
Query: 531 DVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP 584
V GV+G + YD+W V +A++M++ G+P R+ + ++ + L ++ EP
Sbjct: 452 TVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTLECLHGEFDVEP 505
Score = 67.7 bits (158), Expect = 8e-10
Identities = 41/105 (39%), Positives = 62/105 (59%), Gaps = 28/105 (26%)
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLK--GKEYLRILNELIADFD-------------- 453
YS++++++ ++FASI NF++ Y E + G E LR LNE+I+DFD
Sbjct: 980 YSQSYEEIGVMFASIPNFSDFYTEESINNGGIECLRFLNEIISDFDSVSCRPPPAFTCAR 1039
Query: 454 ------------ELLERPQFQHVEKIKTIGSTFMAASGLNPDLRH 486
+LL+ PQF+ + KIKTIGST+MAASG+ PD+ +
Sbjct: 1040 VHGSVTCDLCSRQLLDEPQFRCITKIKTIGSTYMAASGVTPDVNN 1084
>UniRef50_UPI000155CC3E Cluster: PREDICTED: similar to adenylate
cyclase 7; n=1; Ornithorhynchus anatinus|Rep: PREDICTED:
similar to adenylate cyclase 7 - Ornithorhynchus
anatinus
Length = 816
Score = 88.6 bits (210), Expect = 4e-16
Identities = 62/215 (28%), Positives = 103/215 (47%), Gaps = 17/215 (7%)
Query: 391 LLHNIIPRHVADQLKNTAKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIA 450
L N RH D ++ Y + H++V ++A I+ F + + KE + +LNEL
Sbjct: 395 LKENNDTRHAPDNNFHSL-YVKRHQNVXXLYADIVGFTRLASDC--SPKELVVMLNELFG 451
Query: 451 DFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVD 510
FD++ + + +IK +G + SGL L H + L+M + +
Sbjct: 452 KFDQIAKENECM---RIKILGDCYYCVSGLPVSLP-------THARNCVKMGLDMCEAIK 501
Query: 511 NFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGE 570
+ D +R+G + G+V GVIG K YD+W V++A+RM+S GVP R+ + E
Sbjct: 502 QVK-EATGVDISMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMESAGVPGRVHITE 560
Query: 571 ACVPVLSARYEFEP-RGSVYVKGKDDMNV--YLLV 602
A + L YE E G + +MN+ YL++
Sbjct: 561 ATLSHLDKEYEVEEGNGQLRDAYLKEMNIQTYLVI 595
>UniRef50_Q9GT36 Cluster: Guanylate cyclase; n=1; Heterodera
glycines|Rep: Guanylate cyclase - Heterodera glycines
(Soybean cyst nematode worm)
Length = 1112
Score = 88.6 bits (210), Expect = 4e-16
Identities = 65/237 (27%), Positives = 117/237 (49%), Gaps = 19/237 (8%)
Query: 373 VANRDKQRVQNMRNQADWLLHNIIPRHVADQLK-NTAKYSENHKDVAIIFASIINFNEMY 431
V R K+ V+ + + D LL+ ++P+ VAD+LK + E V + F+ +++F +
Sbjct: 867 VEERTKELVEE-KKKTDILLYRMLPKQVADKLKLGQSVEPETFDCVTVFFSDVVSFTTI- 924
Query: 432 DESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGT 491
S + + +LN L D ++ +F V K++TIG ++ SGL R
Sbjct: 925 -ASKCSPLQVVNLLNNLYTLLDSIIA--EFD-VYKVETIGDGYLCVSGL------PHRNG 974
Query: 492 YDHLYQLMDFALEMQKVVDNFNHDLFEFDFI-LRIGYNFGDVTAGVIGTTKLYYDIWGDA 550
++H + +L + + +F + + LRIG + G AGV+G + Y ++GD
Sbjct: 975 HEHAQHIAKMSLAFMRNLGSFTIPHLPIERLRLRIGIHTGSTVAGVVGLSMPRYCLFGDT 1034
Query: 551 VNIASRMDSTGVPQRIQVGEA----CVPVLSARYEFEPRGSVYVKGKDDMNVYLLVG 603
+N A+R++S+ P RI + V VL + + RG + VKGK + + L+G
Sbjct: 1035 INTAARLESSSKPMRIHISTTTNHFLVNVLGG-FVTQARGEILVKGKGVLETFWLLG 1090
>UniRef50_A7S7B2 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 584
Score = 88.6 bits (210), Expect = 4e-16
Identities = 62/238 (26%), Positives = 114/238 (47%), Gaps = 17/238 (7%)
Query: 359 EFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLK---NTAKYSENHK 415
+ E + F + + ++++ R +++ LL+ ++P+ +A++LK N E
Sbjct: 359 QLEYARDQQFEQGIELEENMRKLEEERQRSEDLLYRMVPKPIAERLKRGGNPIDTCEEFD 418
Query: 416 DVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGST-F 474
++F+ + F + L + + ++N L FD L E+ +V K +T+G +
Sbjct: 419 AATVLFSYMDGFTSICTR--LNAMQAVTLINNLFIKFDLLTEK---HNVYKFETLGDALY 473
Query: 475 MAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTA 534
MA SG+ H H + AL+M K V + + + +G + G V A
Sbjct: 474 MAVSGVPVRTEH-------HAEPMAAMALDMLKAVQLVKDPITKKPMTITVGIHSGPVAA 526
Query: 535 GVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-SARYEFEPRGSVYVK 591
G++G L Y ++GD VNIASR+ +T +P RI + E C L + + E RG + +K
Sbjct: 527 GLVGERTLQYCLFGDTVNIASRLRTTALPMRIHISENCRECLEESDFITEFRGEIELK 584
>UniRef50_A0DVQ1 Cluster: Chromosome undetermined scaffold_66, whole
genome shotgun sequence; n=5; Alveolata|Rep: Chromosome
undetermined scaffold_66, whole genome shotgun sequence -
Paramecium tetraurelia
Length = 2408
Score = 88.6 bits (210), Expect = 4e-16
Identities = 68/235 (28%), Positives = 120/235 (51%), Gaps = 15/235 (6%)
Query: 376 RDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYS--ENHKDVAIIFASIINFNEMYDE 433
++K N+ + +L ++P+ + D+L T +Y+ +N VAI+F I NF++M E
Sbjct: 1588 QNKLNFIEQNNKINDILGILLPKFIRDRLNETDQYNIHQNQGLVAIVFCDICNFDQMVTE 1647
Query: 434 SYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNP---DLRHASRG 490
K K + L+++ FD+ Q V+KI+T+G T++A++GL +L + S+
Sbjct: 1648 E--KDK-IITFLDDIFRTFDKYC---QIYGVQKIETVGKTYLASAGLKACEQELTYLSQ- 1700
Query: 491 TYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDA 550
D + + ++ A +M + + + +IG ++G +GVIG K + + GD
Sbjct: 1701 -VDPVQRALNLAEQMMIYIRSKMWGYKGQQLVGKIGIHYGGAISGVIGFHKPQFSLIGDT 1759
Query: 551 VNIASRMDSTGVPQRIQVGEACVPVL-SARYEFEPRGSVYVKGKDDMNVYLLVGK 604
VN SR+ STG+ I + E L + EFE R +V +KG Y+ GK
Sbjct: 1760 VNTTSRICSTGLEDAITLSEQAFDQLKNENIEFEIR-NVEMKGLGTRPTYIFKGK 1813
Score = 75.4 bits (177), Expect = 4e-12
Identities = 56/195 (28%), Positives = 94/195 (48%), Gaps = 15/195 (7%)
Query: 391 LLHNIIPRHVA-----DQLKNTAKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLRIL 445
LL ++P+H+ D++ N + D+ I+FA I F E S + +E L +L
Sbjct: 2183 LLQYLLPKHILNNFLDDRISNIG-ICDKIDDLTILFADIAGFTEY--SSKVNPEEVLVML 2239
Query: 446 NELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEM 505
L +FD + +V K+ TIG ++A ++ + +R ++D A EM
Sbjct: 2240 KNLFVEFDR---KCCDLNVYKLYTIGDCYVAIGMID----YHNRNPQQEAKNIIDLAFEM 2292
Query: 506 QKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQR 565
K++ + +RIG + G V GV+GT + YDI+G V IA++M+S GV
Sbjct: 2293 IKIITQVRKQINFEGLNMRIGVHTGPVFGGVMGTDIVRYDIYGPDVLIANKMESNGVKGN 2352
Query: 566 IQVGEACVPVLSARY 580
+QV ++ L Y
Sbjct: 2353 VQVSQSTKKYLEELY 2367
>UniRef50_A0BPN4 Cluster: Chromosome undetermined scaffold_12, whole
genome shotgun sequence; n=4; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_12, whole genome shotgun
sequence - Paramecium tetraurelia
Length = 2459
Score = 88.6 bits (210), Expect = 4e-16
Identities = 69/241 (28%), Positives = 120/241 (49%), Gaps = 21/241 (8%)
Query: 379 QRVQNMRNQADWLLHNIIPRHVADQLKNT--AKYSENHKDVAIIFASIINFNEMYDESYL 436
Q +Q + Q + +L +++P + ++++ + EN V+IIF I F+++
Sbjct: 1611 QALQTQQEQTNQILKSLLPAFIYEKIEQAEETQIEENQGSVSIIFLEICEFDKILQS--- 1667
Query: 437 KGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL-NPDLRHASRGTYDHL 495
K ++ + L+++ D++ + V+KI+T+G T+MA SGL + ++ + G
Sbjct: 1668 KQRQVVSFLDDIFRVLDKICLQ---YGVQKIETVGKTYMACSGLKSTEIENNKDGLNQQK 1724
Query: 496 YQLMDFALEMQ----KVVDNFNHDLFEFDFI------LRIGYNFGDVTAGVIGTTKLYYD 545
ALE+ K V F ++ E + + ++IG ++G V AGVIG K +
Sbjct: 1725 KNETALALELSLDFLKAVSEFRYEYKEQEIVKLYKLKIKIGIHYGQVFAGVIGYHKPQFS 1784
Query: 546 IWGDAVNIASRMDSTGVPQRIQV-GEACVPVLSARYEFEPRGSVYVKGKDDMNVYLLVGK 604
+ GD VN ASRM STG RI + EA V + F R V KGK + V+ + +
Sbjct: 1785 LIGDTVNTASRMCSTGEVGRITISSEAYERVKDTEFLFTSR-EVEAKGKGHLIVHQVTQR 1843
Query: 605 K 605
K
Sbjct: 1844 K 1844
Score = 74.9 bits (176), Expect = 6e-12
Identities = 60/215 (27%), Positives = 105/215 (48%), Gaps = 16/215 (7%)
Query: 385 RNQADWLLHNIIPRHVADQLKNTAKYSENHKDVAI----IFASIINFNEMYDESYLKGKE 440
+ Q D LL N++P H+ + +K DV I +FA I F Y S + ++
Sbjct: 2228 KEQRDSLLTNLLPSHILTRFYQNSKIKLELSDVLIDATLLFADISGFTA-YSAS-VPAEQ 2285
Query: 441 YLRILNELIADFD-ELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLM 499
+++L +L+ FD E L+ Q+V K+ TIG ++ G+N D+ G ++
Sbjct: 2286 VVKMLRQLMTSFDKECLQ----QNVYKVYTIGDCYVVL-GIN-DMEQRHPG--QEAKNVL 2337
Query: 500 DFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDS 559
+ LEM +++ ++ + +RIG + G G+IGT + YDI+G IA++M+S
Sbjct: 2338 EMGLEMVEIIKKVRREINFQNLNMRIGIHTGQFYGGIIGTDIVRYDIFGIDAVIANKMES 2397
Query: 560 TGVPQRIQVGEACVPVLSARYEFEPRGSVYVKGKD 594
G ++ V E +++ + E Y KG D
Sbjct: 2398 QGEAGKVMVSEDTRRLINIHFPGE-YNFTYNKGVD 2431
>UniRef50_Q96KY6 Cluster: ADCY4 protein; n=20; Euteleostomi|Rep:
ADCY4 protein - Homo sapiens (Human)
Length = 130
Score = 88.2 bits (209), Expect = 6e-16
Identities = 50/109 (45%), Positives = 64/109 (58%), Gaps = 2/109 (1%)
Query: 494 HLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNI 553
HL +++FA+ + +D N F +F LR+G N G V AGVIG K YDIWG+ VN+
Sbjct: 8 HLGTMVEFAVALGSKLDVINKHSFN-NFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNV 66
Query: 554 ASRMDSTGVPQRIQVGEACVPVL-SARYEFEPRGSVYVKGKDDMNVYLL 601
ASRM+STGV +IQV E L S Y RG + VKGK + Y L
Sbjct: 67 ASRMESTGVLGKIQVTEETAWALQSLGYTCYSRGVIKVKGKGQLCTYFL 115
>UniRef50_Q9N9H5 Cluster: Guanylyl cyclase; n=3; Plasmodium
falciparum|Rep: Guanylyl cyclase - Plasmodium falciparum
Length = 4226
Score = 87.8 bits (208), Expect = 7e-16
Identities = 65/247 (26%), Positives = 123/247 (49%), Gaps = 19/247 (7%)
Query: 365 RLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLK-NTAKYSENHKDVAIIFAS 423
R +FY+N A + + N+A LL++++P+HV ++ + + K + H + +FA
Sbjct: 3923 RRTFYANESAKKTE-------NRATELLNDMLPKHVLEEFQQDKLKLAYTHDRLTFLFAD 3975
Query: 424 IINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPD 483
I F + + E L +L +L A FD + ++ + K+ TIG ++A S +
Sbjct: 3976 ICGFTSWANG--VDASEVLTLLQKLFAKFDN--DSTKYG-LYKLCTIGDAYVAISEPVTE 4030
Query: 484 LRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLY 543
+ D ++++ A M +++ L+ + +RIG ++G GVIG+ +L
Sbjct: 4031 -DNKDYDPVDGTERVLEMAYSMIRIIKEIREKLYIPNLNMRIGLHYGSCVGGVIGSGRLR 4089
Query: 544 YDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL----SARYEFEPRGSVYVKGKDDMNVY 599
YD+WG V + M+S G+P +I V E L R+ F+P ++ V K D+ +
Sbjct: 4090 YDLWGIDVLTGNLMESNGIPGKINVSETLKNFLLQQFKNRFIFKPHTTIRVIYK-DVKCF 4148
Query: 600 LLVGKKD 606
++ KK+
Sbjct: 4149 IITDKKE 4155
Score = 56.0 bits (129), Expect = 3e-06
Identities = 30/80 (37%), Positives = 44/80 (55%), Gaps = 1/80 (1%)
Query: 523 LRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVP-VLSARYE 581
+++G + G + AGV+G+ K Y ++GD VN ASRM +TG P I + EA V +
Sbjct: 3235 VKVGIHSGRIIAGVVGSKKPQYALFGDTVNTASRMKTTGKPDYIHISEATYNLVKDDKTL 3294
Query: 582 FEPRGSVYVKGKDDMNVYLL 601
+ +KGK M YLL
Sbjct: 3295 IYEKKETEIKGKGIMTTYLL 3314
>UniRef50_Q95NK5 Cluster: Soluble guanylyl cyclase beta1; n=2;
Strongylocentrotidae|Rep: Soluble guanylyl cyclase beta1
- Hemicentrotus pulcherrimus (Sea urchin)
Length = 604
Score = 87.8 bits (208), Expect = 7e-16
Identities = 65/248 (26%), Positives = 124/248 (50%), Gaps = 23/248 (9%)
Query: 357 NREFEISYRLSFYSNVVANRDKQ---RVQNMRNQADWLLHNIIPRHVADQLKNTAKY-SE 412
+ F+ Y+L+ ++ ++ +Q ++N + + D LL++I+P VA++L++ ++
Sbjct: 349 SERFDEEYKLTQKLEILTDKLQQTYREIENEKKKTDRLLYSILPPSVANELRHHRPVPAK 408
Query: 413 NHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGS 472
+ V ++F+ I F + + + +LN + FD L+E V K++T+G
Sbjct: 409 KFECVTLMFSGIFGFGDFCRRYSHDAMKIVSLLNSVYTKFDVLMENNP--DVYKVETVGD 466
Query: 473 TFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFD-FILRIGYNFGD 531
+MA SGL DH + ALEM+++ + + E D ++ IG G+
Sbjct: 467 KYMAVSGLPVPCA-------DHAKCIAKMALEMKELSADV---IMEGDPIVITIGVYSGE 516
Query: 532 VTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL------SARYEFEPR 585
V GV+G Y ++G+ VN+ SR ++TGV +I + + L ++F+ R
Sbjct: 517 VVTGVVGQRMPRYCLFGNTVNLTSRTETTGVTGKINIADTAYDCLMEPQNADPTFQFDFR 576
Query: 586 GSVYVKGK 593
G V +KGK
Sbjct: 577 GLVNMKGK 584
>UniRef50_Q22AU0 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=2; Tetrahymena|Rep:
Adenylate and Guanylate cyclase catalytic domain
containing protein - Tetrahymena thermophila SB210
Length = 2450
Score = 87.8 bits (208), Expect = 7e-16
Identities = 67/247 (27%), Positives = 118/247 (47%), Gaps = 21/247 (8%)
Query: 367 SFYSNVVANRD----KQRVQNMRNQADWLLHNIIPRHVADQLKNTA--KYSENHKDVAII 420
S+Y+ RD + R++ N+ D +L N++P V + E+ +VAI+
Sbjct: 1528 SYYNKDYLRRDLFLMENRIKFEENKVDHVLANLLPNFVRSRFNRNGDTNIEEDQGEVAIV 1587
Query: 421 FASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL 480
F I++F+E+ E + + ++ L+ L FD + +R V+KI+T+G +MA SGL
Sbjct: 1588 FVEIVSFDEILKE---QDENFIHWLDNLYRSFDYVCQR---YGVQKIETVGKVYMACSGL 1641
Query: 481 NPDLRHASRGTYDHLYQ------LMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTA 534
+ ++ D +++ +D A +QK L+IG ++G V A
Sbjct: 1642 DVAKHQKAKKGNDRIWRENETKKALDAAFAIQKKAQKIYWGSKSQKTTLKIGIHYGRVIA 1701
Query: 535 GVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRGSVY--VKG 592
GVIG K + + GD VN SR+ S I + + + + ++ +G + VKG
Sbjct: 1702 GVIGYHKPQFSLIGDTVNTTSRVCSHCEANNITLSQQAHERVKDQ-DYVSKGEIVKNVKG 1760
Query: 593 KDDMNVY 599
K D+ VY
Sbjct: 1761 KGDLQVY 1767
Score = 81.4 bits (192), Expect = 6e-14
Identities = 62/235 (26%), Positives = 117/235 (49%), Gaps = 26/235 (11%)
Query: 380 RVQNMRNQADWLLHNIIPRHVA-----DQLKNTAKYSENHKDVAIIFASIINFNEMYDES 434
++ N + + D LL +++P+HV DQ K ++ E +DV ++FA I F +S
Sbjct: 2232 KLDNKKTEKDSLLRHLLPQHVLTKFFQDQQKKQ-EFQETLQDVTLLFADISGFTSYSSKS 2290
Query: 435 YLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDH 494
+ ++ +++L EL +FD+ ++V K+ TIG + +N + H +
Sbjct: 2291 --RPEDVVKMLRELFIEFDKSCIT---RNVYKVYTIGGM----TNINNRIIH------EE 2335
Query: 495 LYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIA 554
++D M K + + D +RIG + G + G++GT + YDI+G V IA
Sbjct: 2336 AKNVVDMGFSMIKTIQYVRDKVNNSDLQMRIGIHTGKILGGILGTNIVRYDIFGKDVMIA 2395
Query: 555 SRMDSTGVPQRIQVGEACVPVLSARY----EFEPRGSVYVKG-KDDMNVYLLVGK 604
++++S GV +I V EA +L Y +F+ + +K ++++ YL+ K
Sbjct: 2396 NKVESNGVGGQISVSEATKVLLENNYKDIFQFKDHNPIKLKNFEEEIKTYLVKQK 2450
>UniRef50_Q18331 Cluster: Guanylyl cyclase protein 11; n=2;
Caenorhabditis|Rep: Guanylyl cyclase protein 11 -
Caenorhabditis elegans
Length = 1032
Score = 87.8 bits (208), Expect = 7e-16
Identities = 67/233 (28%), Positives = 121/233 (51%), Gaps = 16/233 (6%)
Query: 371 NVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKY-SENHKDVAIIFASIINFNE 429
+V+ R +Q +++ R + + LL ++P+ VA+ LKN +E + V+I F+ I+ F
Sbjct: 776 DVIKERTEQ-LEDERKRNESLLLQLLPKSVANSLKNGQPVDAEFYDSVSIYFSDIVGFTA 834
Query: 430 MYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASR 489
+ +S + + +LN L +FD ++++ F K++TIG +M SGL P++
Sbjct: 835 LSSKS--TPLQVVNMLNNLYTNFDTIIDK--FD-CYKVETIGDAYMFVSGL-PEVN---- 884
Query: 490 GTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFI-LRIGYNFGDVTAGVIGTTKLYYDIWG 548
+Y H ++ +LE+ + F + + LRIG + G V GV+G Y ++G
Sbjct: 885 -SYLHAGEVASASLELLDSIKTFTVSHCPDEKLRLRIGNHTGPVVTGVVGIRMPRYCLFG 943
Query: 549 DAVNIASRMDSTGVPQRIQVGEACVPVL--SARYEFEPRGSVYVKGKDDMNVY 599
D V IA+ M+S+G P RIQ+ ++ Y E R + +K K ++ Y
Sbjct: 944 DTVIIANMMESSGEPMRIQISSDAYELILKCGGYVTEQREKIVLKNKLEVMTY 996
>UniRef50_Q4SW10 Cluster: Guanylate cyclase; n=4; Tetraodontidae|Rep:
Guanylate cyclase - Tetraodon nigroviridis (Green puffer)
Length = 1128
Score = 87.0 bits (206), Expect = 1e-15
Identities = 69/217 (31%), Positives = 109/217 (50%), Gaps = 16/217 (7%)
Query: 365 RLSFYSNVVANRDKQRVQ---NMRNQADWLLHNIIPRHVADQLKN-TAKYSENHKDVAII 420
R+ Y+N + ++R Q + +A+ LL+ I+P VA+QLK +E V I
Sbjct: 894 RMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIY 953
Query: 421 FASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL 480
F+ I+ F + ES E + +LN+L FD +++ +V K++TIG +M SGL
Sbjct: 954 FSDIVGFTAISAES--TPLEVVTLLNDLYTCFDAIIDN---FNVYKVETIGDAYMVVSGL 1008
Query: 481 NPDLRHASRGTYDHLYQLMDFALEMQKVVDNFN-HDLFEFDFILRIGYNFGDVTAGVIGT 539
+R+ + H ++ AL + V F E LRIG + G V AGV+G
Sbjct: 1009 --PVRNGAL----HAPEIARMALALLDAVRTFQIRHRPEEQLKLRIGIHSGPVCAGVVGL 1062
Query: 540 TKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL 576
Y ++GD VN +SRM+S+G +I V A +L
Sbjct: 1063 KMPRYCLFGDTVNTSSRMESSGEALKIHVSAATGDIL 1099
>UniRef50_A0C5P9 Cluster: Chromosome undetermined scaffold_150, whole
genome shotgun sequence; n=5; Oligohymenophorea|Rep:
Chromosome undetermined scaffold_150, whole genome
shotgun sequence - Paramecium tetraurelia
Length = 2413
Score = 87.0 bits (206), Expect = 1e-15
Identities = 61/217 (28%), Positives = 117/217 (53%), Gaps = 18/217 (8%)
Query: 391 LLHNIIPRHVADQLKNTAKYS--ENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNEL 448
+L ++P+ + D++ +Y E+ VA++F II+F+++ + IL++L
Sbjct: 1607 ILSILLPQFIRDRINKAGQYDIQEDQGMVAVLFCDIIDFDQLIKNEQ---SNVVDILDKL 1663
Query: 449 IADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKV 508
FD L ++ + V+KI+T+G T+MAA+GL + S + + +++ AL+M++
Sbjct: 1664 FRRFDLLCQQHE---VQKIETVGKTYMAAAGLKIHMSQKS----NPVNKVISLALDMKRH 1716
Query: 509 VDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQV 568
V ++++F+ ++IG ++G+V AGVIG K + + GD +N ASR+ ST P I +
Sbjct: 1717 V--MSNEVFQ----IKIGIHYGNVIAGVIGHHKPQFSLIGDTINTASRICSTAEPWDIAI 1770
Query: 569 GEACVPVLSARYEFEPRGSVYVKGKDDMNVYLLVGKK 605
E + + V KGK + Y++ K+
Sbjct: 1771 SEQAYRQTNKFELVYVQRDVVAKGKGKLITYVVNTKR 1807
Score = 62.9 bits (146), Expect = 2e-08
Identities = 58/222 (26%), Positives = 108/222 (48%), Gaps = 20/222 (9%)
Query: 368 FYSNVVA-NRDKQRVQNMRNQADWLLHNIIPRHVADQL--KNTAK--YSENHKDVAIIFA 422
F NV + N +KQ ++ +LL+ ++P++V ++ N K E +V ++FA
Sbjct: 2175 FLKNVNSYNVNKQLIEKSIKY-QFLLNYLLPKNVLEEFFRPNEEKRVLREQADEVTLLFA 2233
Query: 423 SIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNP 482
I F E Y S ++ ++ + +L L +FD+ +V K+ TIG ++ G+
Sbjct: 2234 DIAGFTE-YSSS-VQPEQVVNMLRNLFTEFDK---NCLLHNVFKLYTIGDCYVVM-GMVD 2287
Query: 483 DLRHASRGTYDHLYQL--MDFAL--EMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIG 538
+ R + M FA+ +++V + NH + +RIG + G + GV+G
Sbjct: 2288 YGKGIQRNPSQEAVNVVRMGFAMIDAIRRVRAHINHPTLD----MRIGVHTGSIIGGVLG 2343
Query: 539 TTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARY 580
T + YDI+G V IA++M+S G +QV + ++ +
Sbjct: 2344 TELVRYDIYGPDVLIANKMESKGAKGFVQVSQETKDIIEKEF 2385
>UniRef50_Q5SR07 Cluster: Natriuretic peptide receptor A/guanylate
cyclase A; n=14; cellular organisms|Rep: Natriuretic
peptide receptor A/guanylate cyclase A - Homo sapiens
(Human)
Length = 255
Score = 87.0 bits (206), Expect = 1e-15
Identities = 75/231 (32%), Positives = 112/231 (48%), Gaps = 20/231 (8%)
Query: 369 YSNVVANRDKQRVQ---NMRNQADWLLHNIIPRHVADQLKN-TAKYSENHKDVAIIFASI 424
Y+N + ++R Q + +A+ LL+ I+P VA+QLK +E V I F+ I
Sbjct: 4 YANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDI 63
Query: 425 INFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDL 484
+ F + ES + + +LN+L FD +++ F V K++TIG +M SGL
Sbjct: 64 VGFTALSAES--TPMQVVTLLNDLYTCFDAVIDN--FD-VYKVETIGDAYMVVSGL---- 114
Query: 485 RHASRGTYDHLYQLMDFALEMQKVVDNFN--HDLFEFDFILRIGYNFGDVTAGVIGTTKL 542
R H ++ AL + V +F H E LRIG + G V AGV+G
Sbjct: 115 --PVRNGRLHACEVARMALALLDAVRSFRIRHRPQE-QLRLRIGIHTGPVCAGVVGLKMP 171
Query: 543 YYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLS--ARYEFEPRGSVYVK 591
Y ++GD VN ASRM+S G +I + VL +E E RG V +K
Sbjct: 172 RYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMK 222
>UniRef50_P90895 Cluster: Soluble guanylate cyclase gcy-33; n=2;
Caenorhabditis|Rep: Soluble guanylate cyclase gcy-33 -
Caenorhabditis elegans
Length = 945
Score = 87.0 bits (206), Expect = 1e-15
Identities = 66/237 (27%), Positives = 119/237 (50%), Gaps = 23/237 (9%)
Query: 379 QRVQNMRNQADWLLHNIIPRHVADQLKNTAK--YSENHKDVAIIFASIINFNEMYDESYL 436
+ + + A LL ++P VA + + + E + V+I F + +F+++ ++
Sbjct: 396 REISEAKKTARTLLTQMMPYEVAQTMMRSGSVDHCEAFECVSIGFIRVCDFSKI--SLFI 453
Query: 437 KGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLY 496
+ E + +LN + + D +++ V K++TIG ++M ++G R YD
Sbjct: 454 EAFEVVNLLNTIYSHLDSIVDT---HGVYKVETIGESYMISAGC------PYRDDYD-AE 503
Query: 497 QLMDFALEMQKVVDNF---NHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNI 553
+ D LEM + +F +HD + +++ G G V GV+G Y ++GD VN
Sbjct: 504 MVSDCCLEMVSHIKSFEYQSHDAVK-KVLIKCGIFTGPVVGGVVGVRTPRYCLFGDTVNT 562
Query: 554 ASRMDSTG-VPQRIQVGEACVPVL----SARYEFEPRGSVYVKGKDDMNVYLLVGKK 605
ASRM+S+ P IQ+G+ + S + +P+G+V+VKGK DM VY + KK
Sbjct: 563 ASRMESSNQTPMTIQIGQRTKDRVEKQASGAFRIKPKGNVFVKGKGDMRVYEIEKKK 619
>UniRef50_A7RUA8 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 443
Score = 86.6 bits (205), Expect = 2e-15
Identities = 60/225 (26%), Positives = 120/225 (53%), Gaps = 16/225 (7%)
Query: 371 NVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLK-NTAKYSENHKDVAIIFASIINFNE 429
++V R +Q ++ +++ D LL+ ++PR +ADQLK +E+ +V + + I++F
Sbjct: 230 SLVKERTRQ-LETEKSKTDELLYRMLPRLIADQLKAGLPLKAESFSEVTVFYCDIVDFTV 288
Query: 430 MYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASR 489
+ S + + +++LN++ + FD ++ R + K++T+ + + SGL P+ R+ +R
Sbjct: 289 ITALS--EPMQVIKLLNDVYSLFDTIMGR---YDIYKVETVRDSCLVVSGL-PE-RNGNR 341
Query: 490 GTYDHLYQLMDFALEMQKVVDNFNHD-LFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWG 548
H ++ +L + V +F + L + R+ + G AG++G K YDI+G
Sbjct: 342 ----HASEIAAMSLHLLNYVTDFRIEHLPDTRLEFRMAIHTGPCVAGIVGLKKPRYDIFG 397
Query: 549 DAVNIASRMDSTGVPQRIQVGEACVPVLS--ARYEFEPRGSVYVK 591
+ VNI ++S G+PQ I V +L+ + E RG + +K
Sbjct: 398 ETVNIVKHLESAGIPQSIHVSSPTCRLLTTLGGFMLETRGEMLIK 442
>UniRef50_A0C5Y1 Cluster: Chromosome undetermined scaffold_151, whole
genome shotgun sequence; n=2; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_151, whole genome
shotgun sequence - Paramecium tetraurelia
Length = 2641
Score = 86.6 bits (205), Expect = 2e-15
Identities = 60/225 (26%), Positives = 117/225 (52%), Gaps = 15/225 (6%)
Query: 360 FEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQ-LKNTAK--YSENHKD 416
F + Y + FY ++ +K+ ++ +NQ++ L+ ++P H+ Q L N + E ++
Sbjct: 2379 FSVQYNI-FYQDLNTFNNKRSLEIKKNQSENLVKYLLPNHILKQFLSNNQREVLVEQLEE 2437
Query: 417 VAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMA 476
++FA I F E S ++ ++ + +L L +FD+ + Q+ K+ TIG ++A
Sbjct: 2438 ATLLFADIAGFTEY--SSKVEPEQVVNMLRNLFTEFDK---KCLTQNTYKLYTIGDCYVA 2492
Query: 477 ASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFI-LRIGYNFGDVTAG 535
+ D+R R +++ M +++ N + FD + +RIG + G V AG
Sbjct: 2493 VGII--DIRQ--RNPAQEAKNVVELGFGMIEIIRNVRQ-IIGFDGLDMRIGIHTGKVIAG 2547
Query: 536 VIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARY 580
++GT + YD++G V I+++M+S G R+QV E +L +Y
Sbjct: 2548 ILGTEIVRYDVYGADVMISNKMESNGEKGRVQVSEETKQLLEIQY 2592
Score = 82.2 bits (194), Expect = 4e-14
Identities = 64/238 (26%), Positives = 117/238 (49%), Gaps = 18/238 (7%)
Query: 365 RLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL--KNTAKYSENHKDVAIIFA 422
R F +V N++ ++ N+ L ++P+ + D++ K + SEN +V+I+F
Sbjct: 1753 REDFMLDVTLNQETSKMTNV-------LSILLPKFIRDRINAKGMFEISENQGNVSILFC 1805
Query: 423 SIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNP 482
I F+++ ++ + ++IL+ L FD+L + Q K++T+G T+MAA GL
Sbjct: 1806 DICGFDDLIT---VEKENIVKILDGLFRSFDQLCAQNGMQ---KVETVGKTYMAAGGLKA 1859
Query: 483 DLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKL 542
+ + + + + +LEM + ++IG ++G V AGVIG K
Sbjct: 1860 VDQGTKFYNQNCVKRAVQLSLEMMDHTRKVKYGQIGH-LTIKIGIHYGRVIAGVIGHHKP 1918
Query: 543 YYDIWGDAVNIASRMDSTGVPQRIQV-GEACVPVLSARYEFEPRGSVYVKGKDDMNVY 599
+ + GD VN SR+ STG ++ + EA + + +F R V KGK ++ Y
Sbjct: 1919 QFSLIGDTVNTTSRVCSTGQDGQVTLSNEAYLEINMPELQFTQR-KVAAKGKGELITY 1975
>UniRef50_A5K544 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Plasmodium vivax|Rep:
Adenylate and Guanylate cyclase catalytic domain
containing protein - Plasmodium vivax
Length = 3979
Score = 86.2 bits (204), Expect = 2e-15
Identities = 67/247 (27%), Positives = 122/247 (49%), Gaps = 19/247 (7%)
Query: 365 RLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLK-NTAKYSENHKDVAIIFAS 423
R +FY+N A + + N+A LL++++P+HV ++ + + K + H + +FA
Sbjct: 3674 RRTFYANESAKKTE-------NRATELLNDMLPKHVLEEFQQDRLKLAYTHDRLTFLFAD 3726
Query: 424 IINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPD 483
I F + + E L +L +L A FD + ++ + K+ TIG ++A S +
Sbjct: 3727 ICGFTSWANG--VDASEVLTLLQKLFAKFDN--DSTKYG-LYKLCTIGDAYVAISEPVTE 3781
Query: 484 LRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLY 543
+ D ++++ A M +++ L + +RIG ++G GVIG+ +L
Sbjct: 3782 -DNQDYDPVDGTERVLEMAYSMIRIIKEIREKLCIPNLNMRIGLHYGSCVGGVIGSGRLR 3840
Query: 544 YDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL----SARYEFEPRGSVYVKGKDDMNVY 599
YD+WG V + M+S GVP +I V E L R+ F+P +V V K D+ +
Sbjct: 3841 YDLWGIDVLTGNLMESNGVPGKINVSETLKNFLLQQFKNRFIFKPHTTVRVIYK-DVKSF 3899
Query: 600 LLVGKKD 606
++ KK+
Sbjct: 3900 IITDKKE 3906
Score = 59.3 bits (137), Expect = 3e-07
Identities = 32/80 (40%), Positives = 44/80 (55%), Gaps = 1/80 (1%)
Query: 523 LRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVP-VLSARYE 581
++IG N G + AGV+G+ K Y ++GD VN ASRM +TG P I + EA V +
Sbjct: 2992 VKIGINSGRIIAGVVGSKKPQYALFGDTVNTASRMKTTGKPDYIHISEATYDLVKDDKTL 3051
Query: 582 FEPRGSVYVKGKDDMNVYLL 601
+ +KGK M YLL
Sbjct: 3052 VYEKKETEIKGKGTMTTYLL 3071
>UniRef50_A2EII6 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1295
Score = 85.8 bits (203), Expect = 3e-15
Identities = 63/226 (27%), Positives = 112/226 (49%), Gaps = 14/226 (6%)
Query: 378 KQRVQNMRNQADWLLHNIIPRHVADQLKNTAK-YSENHKDVAIIFASIINFNEMYDESYL 436
K++ + + +++ LL+ I+PR + QL K + IIF I F+E L
Sbjct: 1062 KKQAEEAKAKSEKLLYQILPRDIVVQLNKGEKDITFTVNSATIIFIDINKFSEC--SKNL 1119
Query: 437 KGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL-NPDLRHASRGTYDHL 495
++ + L+ A D++ + + + KIK IG +MAA+GL NP++ H
Sbjct: 1120 SPQDIMSNLSYYFACIDKISAK--YNMILKIKLIGDIYMAAAGLFNPEVNPEQ-----HA 1172
Query: 496 YQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGD-VTAGVIGTTKLYYDIWGDAVNIA 554
Q + F E+ +++ N L + +R+G N G + AGV+GT K +DI GD +N+A
Sbjct: 1173 EQAVLFGQEIVNILEEINLRL-SANLQIRVGVNSGGPIIAGVLGTDKPAFDIIGDVINVA 1231
Query: 555 SRMDSTGVPQRIQVGEACVPVLSA-RYEFEPRGSVYVKGKDDMNVY 599
+R+ ST ++ + +A + ++ E G ++KGK Y
Sbjct: 1232 ARLQSTSDVNKVHISQATLDLVKGMNCEVTQCGETFLKGKGKQLTY 1277
>UniRef50_Q6WIQ8 Cluster: Adenylate cyclase type VII; n=2;
Xenopus|Rep: Adenylate cyclase type VII - Xenopus laevis
(African clawed frog)
Length = 667
Score = 85.4 bits (202), Expect = 4e-15
Identities = 55/199 (27%), Positives = 105/199 (52%), Gaps = 16/199 (8%)
Query: 407 TAKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEK 466
TA Y + H++V+I++A I+ F + + KE + +LNEL FD++ + + +
Sbjct: 159 TALYVKRHQNVSILYADIVGFTRLASDC--SPKELVVMLNELFGKFDQIAKENECM---R 213
Query: 467 IKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIG 526
IK +G + SGL L + ++ + +D +++V + D+ +R+G
Sbjct: 214 IKILGDCYYCVSGLPVSLPNNAKNC---VKMGLDICESIKQVREATGADIN-----MRVG 265
Query: 527 YNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP-R 585
+ G+V GVIG K +D+W V++A+RM+S G+P R+ + EA + ++ Y+ E
Sbjct: 266 VHSGNVLCGVIGLRKWQFDVWSHDVSLANRMESAGLPGRVHITEATLKHMNGAYDVEEGH 325
Query: 586 GSVYVKGKDDMNV--YLLV 602
G + +MN+ YL++
Sbjct: 326 GELRDPYLKEMNIKTYLVI 344
>UniRef50_Q8IGU9 Cluster: RE26442p; n=4; Sophophora|Rep: RE26442p -
Drosophila melanogaster (Fruit fly)
Length = 1162
Score = 84.2 bits (199), Expect = 9e-15
Identities = 53/175 (30%), Positives = 90/175 (51%), Gaps = 15/175 (8%)
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
+ E H+DV +++A ++N+ + + L K+ + L++L FD E +V +IK
Sbjct: 319 FIEPHEDVTVLYADVVNYTHL--TTTLDVKKLVEALHDLFVRFDIASEE---YNVLRIKF 373
Query: 470 IGSTFMAASGL-NPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYN 528
+G + +GL NP+ DH +D L M K + + + +RIG +
Sbjct: 374 LGDCYYCVAGLANPNA--------DHAKCCVDLGLRMIKDIRDVREKR-HLNIDMRIGVH 424
Query: 529 FGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFE 583
GDV +GVIG K +DIW V+IA+R+++TG R+ V + + +L Y FE
Sbjct: 425 SGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLDGEYFFE 479
Score = 82.6 bits (195), Expect = 3e-14
Identities = 45/132 (34%), Positives = 75/132 (56%), Gaps = 8/132 (6%)
Query: 478 SGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDF-------ILRIGYNFG 530
SG H + + + + +FAL++ + + FN + + ++ +LRIG + G
Sbjct: 1011 SGPRISSTHNGSSSNEVVRVMAEFALDLMRTMRRFNTENMQTEYEGSTDYGMLRIGISHG 1070
Query: 531 DVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGE-ACVPVLSARYEFEPRGSVY 589
AGV+G +K +YDIWG+ VN+ASRMDSTGVP +IQV E + + + RG +
Sbjct: 1071 RAMAGVVGISKPHYDIWGNPVNMASRMDSTGVPGQIQVTENTALKLREFNIQCNYRGMTF 1130
Query: 590 VKGKDDMNVYLL 601
VKG+ ++ Y++
Sbjct: 1131 VKGRGNIPTYII 1142
Score = 65.7 bits (153), Expect = 3e-09
Identities = 45/97 (46%), Positives = 59/97 (60%), Gaps = 15/97 (15%)
Query: 391 LLHNIIPRHVAD-----QLKNTAKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLRIL 445
LL NI+P HVAD QL+N Y E + +VA++FASI NF+ K LR+L
Sbjct: 856 LLTNILPTHVADFYLSNQLQNELYYEE-YDNVAVMFASIKNFDT--------DKIGLRVL 906
Query: 446 NELIADFDELLER-PQFQHVEKIKTIGSTFMAASGLN 481
NE+I DFD++L + Q VEKIK T+MAA GL+
Sbjct: 907 NEIICDFDDVLNKYSQSLRVEKIKVANWTYMAACGLD 943
>UniRef50_O62026 Cluster: Putative uncharacterized protein gcy-29;
n=1; Caenorhabditis elegans|Rep: Putative uncharacterized
protein gcy-29 - Caenorhabditis elegans
Length = 1034
Score = 84.2 bits (199), Expect = 9e-15
Identities = 64/225 (28%), Positives = 115/225 (51%), Gaps = 16/225 (7%)
Query: 387 QADWLLHNIIPRHVADQLKNTAKYSENHKDVA-IIFASIINFNEMYDESYLKGKEYLRIL 445
+A+ LL ++P+HVA +LK + D A ++F+ I+ F ++ S E + +L
Sbjct: 809 RAERLLFQLLPKHVAIELKAGRTVAPKMYDSATVMFSDIVGFTKLCSAS--TPIEVVNLL 866
Query: 446 NELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEM 505
N+L ++FD ++ + K++TIG +M SG+ + + R H+ + L +
Sbjct: 867 NKLYSEFDTVISK---HDCYKVETIGDAYMVVSGI--PIENGQR----HVANISAVTLGI 917
Query: 506 QKVVDNFN-HDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQ 564
++ F ++ +R+G+ G V+A V+G + Y ++G+ VNIA+ M+S+G
Sbjct: 918 MDLLKVFEVPHRRDYRLTIRLGFASGQVSAAVVGLSSPRYCLFGETVNIAAVMESSGEGG 977
Query: 565 RIQVGEACVPVLSARY-EF--EPRGSVYVKGKDDMNVYLLVGKKD 606
R+Q+ E +L Y EF E RG +DD Y L GK +
Sbjct: 978 RVQITETSKILLENEYPEFIIEIRGINKDVKQDDFVTYWLTGKDE 1022
>UniRef50_O16544 Cluster: Guanylate cyclase; n=3; Caenorhabditis|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1143
Score = 84.2 bits (199), Expect = 9e-15
Identities = 65/241 (26%), Positives = 117/241 (48%), Gaps = 26/241 (10%)
Query: 373 VANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYS-ENHKDVAIIFASIINFNEMY 431
V +R K+ + +AD LL ++P+ VA++LK E V + F+ ++ F ++
Sbjct: 815 VEDRTKELTAE-KKKADVLLGRMLPKQVAERLKQGQTVEPEGFDSVTVFFSDVVKFTQL- 872
Query: 432 DESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGT 491
+ + + +LN+L ++FD ++E K+++IG ++ SGL S+
Sbjct: 873 -AAKCSPFQVVNLLNDLYSNFDAIIEE---HGCYKVESIGDGYLCVSGL------PSKNG 922
Query: 492 YDHLYQLMDFALEMQKVVDNFNHDLFEFDFI-LRIGYNFGDVTAGVIGTTKLYYDIWGDA 550
H+ Q+++ +L+ +F + + LRIG N G AGV+G + Y ++GD
Sbjct: 923 NAHIKQIVELSLDFMSYCKSFKIPHLPREKVELRIGVNSGPCVAGVVGLSMPRYCLFGDT 982
Query: 551 VNIASRMDSTGVPQRIQVGEACVPVLSA------------RYEFEPRGSVYVKGKDDMNV 598
VN ASRM+S G +++ + + LSA +Y RG V +KGK M
Sbjct: 983 VNTASRMESNGKGRQMALKSSSHIHLSAASYTLLMKHYPNQYNTASRGDVIIKGKGVMET 1042
Query: 599 Y 599
+
Sbjct: 1043 F 1043
>UniRef50_A2DLQ6 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=3; Eukaryota|Rep: Adenylate
and Guanylate cyclase catalytic domain containing protein
- Trichomonas vaginalis G3
Length = 1545
Score = 84.2 bits (199), Expect = 9e-15
Identities = 62/247 (25%), Positives = 120/247 (48%), Gaps = 21/247 (8%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMR---------NQADWLLHNIIPRHVADQLKNT 407
N +F +S + ++ V A K QN+R ++D LL +I+P + +++
Sbjct: 1297 NTKFNLSVKSLSFNQVTAYLFKDITQNVRYNTLIDEERGKSDKLLESILPAKLVRRVQQG 1356
Query: 408 AK-YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEK 466
K S + + +++F I++F L + ILN L +FD + F + K
Sbjct: 1357 EKNISFSVQSASVVFMDIVSFTPWCGS--LPANRVMEILNRLYKEFDAKVA--SFPTMTK 1412
Query: 467 IKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIG 526
IK IG +MAA G+ ++ + H ++++F +E V N + + +R+G
Sbjct: 1413 IKCIGDCYMAAGGIFAEINQPAV----HAKEIVEFGIEAIGAVGVVNEETKQ-SLQIRVG 1467
Query: 527 YNFGD-VTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-SARYEFEP 584
N G + AGV+G+ K ++I G +N+A +M+ GVP ++ + A ++ ++ +
Sbjct: 1468 INTGGPLVAGVLGSGKPTFEILGPTINMAQQMEHHGVPMQVHISRAVYELIYGGNFKIKE 1527
Query: 585 RGSVYVK 591
RG + +K
Sbjct: 1528 RGQIEIK 1534
>UniRef50_Q9XVV4 Cluster: Guanylate cyclase; n=2; Caenorhabditis|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1161
Score = 83.8 bits (198), Expect = 1e-14
Identities = 73/252 (28%), Positives = 122/252 (48%), Gaps = 34/252 (13%)
Query: 373 VANRDKQRVQNMRNQADWLLHNIIPRHVADQLK-NTAKYSENHKDVAIIFASIINFNEMY 431
VA R K+ V+ + ++D LL+ ++PR VAD+LK E V + F+ +++F +
Sbjct: 906 VAERMKELVEE-KKKSDVLLYRMLPRQVADKLKLGQTVEPETFDIVTLFFSDVVSFTTLA 964
Query: 432 DESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGT 491
+ + + +LN L FD ++E+ V K++TIG + ASG+ R
Sbjct: 965 GKC--TPLQVVNLLNGLYTIFDGIIEQ---HDVYKVETIGDGYFVASGV------PRRNG 1013
Query: 492 YDHLYQLMDFALEMQKVVDNFNHDLFEFDFI-LRIGYNFGDVTAGVIGTTKLYYDIWGDA 550
+H + ++ K + +F+ + I +R+G++ G V AGV+G T Y ++GDA
Sbjct: 1014 NEHTRNIASMSINFVKSLADFSIPHLPGEKIKIRVGFHCGSVVAGVVGLTMPRYCLFGDA 1073
Query: 551 VNIASRMD----------STGVPQ--------RIQVGEACVPVLS--ARYEFEPRGSVYV 590
VN ASRM+ ST + +I + E +L + EPRG V +
Sbjct: 1074 VNTASRMESNSKRKIFQKSTNISSSFHLFSAGQIHLSEEANQMLMRLGGFTTEPRGEVII 1133
Query: 591 KGKDDMNVYLLV 602
KGK M Y L+
Sbjct: 1134 KGKGVMATYWLL 1145
>UniRef50_A0DTD8 Cluster: Chromosome undetermined scaffold_63, whole
genome shotgun sequence; n=6; Eukaryota|Rep: Chromosome
undetermined scaffold_63, whole genome shotgun sequence -
Paramecium tetraurelia
Length = 2465
Score = 83.8 bits (198), Expect = 1e-14
Identities = 67/226 (29%), Positives = 113/226 (50%), Gaps = 11/226 (4%)
Query: 386 NQADWLLHNIIPRHVADQLKNTAKYS--ENHKDVAIIFASIINFNEMYDESYLKGKEYLR 443
N+ + +L ++P+ V +L T +Y+ +N +VAI+F I NF+++ E + +
Sbjct: 1637 NKINDILGILLPKFVRHRLNETDQYNIHQNQGNVAIVFCDICNFDQIIMEEQ---ENIIS 1693
Query: 444 ILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNP-DLRHASRGTYDHLYQLMDFA 502
L++L FD+ E V+KI+T+G T+MAA+GL + A + + ++ A
Sbjct: 1694 FLDDLFRTFDKYCE---ICGVQKIETVGKTYMAAAGLKACEQELAYLSEIQPVQRALNLA 1750
Query: 503 LEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGV 562
M + + I +IG ++G +GVIG K + + GD VN SR+ STG
Sbjct: 1751 EMMITYIRSKLWGHQSQPLIGKIGIHYGRAISGVIGFHKPQFSLIGDTVNTTSRVCSTGQ 1810
Query: 563 PQRIQVGEACVPVL-SARYEFEPRGSVYVKGKDDMNVYLLVGKKDT 607
RI + E L + + EFE R V +KG Y+ + K +T
Sbjct: 1811 EDRIILSEKAFEQLKNEKIEFEVR-YVEMKGLGQRPTYVYIQKGNT 1855
Score = 79.4 bits (187), Expect = 3e-13
Identities = 61/215 (28%), Positives = 103/215 (47%), Gaps = 15/215 (6%)
Query: 372 VVANRDKQRVQNMRNQADWLLHNIIPRHVA----DQLKNTAKYSENHKDVAIIFASIINF 427
V K Q+ + + LL ++P+H+ D T S+ ++V I+FA I F
Sbjct: 2209 VACFNQKNIFQSQQAKESQLLQYLLPKHILQTFLDDNNRTRCLSDKIENVTILFADIAGF 2268
Query: 428 NEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHA 487
E S + +E L +L L +FD +V K+ TIG ++A ++ +
Sbjct: 2269 TEY--SSKVTPEEVLLMLKNLFVEFDRKCYE---LNVYKLYTIGDCYVAFGMID----YN 2319
Query: 488 SRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFI-LRIGYNFGDVTAGVIGTTKLYYDI 546
R + ++D A EM ++++ + FD + +RIG + G V GV+GT + YDI
Sbjct: 2320 ERNPTEEAKNIVDLAFEMIRIIEVVRKQI-NFDGLDMRIGIHTGCVLGGVMGTDIVRYDI 2378
Query: 547 WGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYE 581
+G V IA++M+S G ++ V E +L YE
Sbjct: 2379 YGPDVLIANKMESNGKKGQVHVSEITKQLLEQDYE 2413
>UniRef50_A0CEN0 Cluster: Chromosome undetermined scaffold_172, whole
genome shotgun sequence; n=4; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_172, whole genome
shotgun sequence - Paramecium tetraurelia
Length = 2514
Score = 83.8 bits (198), Expect = 1e-14
Identities = 61/205 (29%), Positives = 106/205 (51%), Gaps = 12/205 (5%)
Query: 398 RHVADQLKNTAKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLE 457
R++ +Q K EN +VAI+F I F+++ + + + +L+ L +D L
Sbjct: 1727 RNIINQ-KGEFDIQENQGEVAILFCDICQFDKIIKA---EKENVIHLLDILFRQYDSLCS 1782
Query: 458 RPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLF 517
+ Q KI+T+G T+MAA+GL S+ + + + + + A EM+K +
Sbjct: 1783 QYGLQ---KIETVGKTYMAAAGLK---NIVSQNSANPVLRAIQVAFEMRKFASQQDF-CG 1835
Query: 518 EFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLS 577
+ I++IG ++G+V AGVIG K + + GD VN SR+ STG +I++ E ++S
Sbjct: 1836 SGEIIVKIGVHYGNVIAGVIGYHKPQFSLIGDTVNTTSRVCSTGQDGQIKISEDAYKLVS 1895
Query: 578 ARYEF-EPRGSVYVKGKDDMNVYLL 601
+F + V KGK + Y+L
Sbjct: 1896 GSQDFIFTKDFVEAKGKGVLVTYIL 1920
Score = 77.0 bits (181), Expect = 1e-12
Identities = 56/222 (25%), Positives = 109/222 (49%), Gaps = 13/222 (5%)
Query: 368 FYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL----KNTAKYSENHKDVAIIFAS 423
F NV +K +++ Q D L+ + +P H+ +Q + A +++++V ++FA
Sbjct: 2260 FNKNVQLYNNKCKLKAKHQQLDSLVKHQLPSHMLEQFLKFQQQRAVLKDSYENVTLLFAD 2319
Query: 424 IINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPD 483
I F E S + ++ + +L L +FD+ + + V K+ TIG ++ L+
Sbjct: 2320 IAGFTEY--SSKVSPEQVVFMLRNLFTEFDKCCQE---KSVYKLYTIGDCYVVMGMLDAK 2374
Query: 484 LRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLY 543
R+ ++ + + + +++V D+ N + +RIG + G++ GV+GT +
Sbjct: 2375 DRNIAQEAKNTVELGFEMISIIKRVRDHINFQGLD----MRIGIHTGNIIGGVLGTEIVR 2430
Query: 544 YDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPR 585
YDI+G V IA++M+S G +QV +L Y E R
Sbjct: 2431 YDIYGPDVLIANKMESKGERGNLQVSSTTKEILEQHYPEEFR 2472
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.324 0.138 0.423
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 664,779,113
Number of Sequences: 1657284
Number of extensions: 27629580
Number of successful extensions: 108787
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 342
Number of HSP's successfully gapped in prelim test: 226
Number of HSP's that attempted gapping in prelim test: 107247
Number of HSP's gapped (non-prelim): 879
length of query: 607
length of database: 575,637,011
effective HSP length: 105
effective length of query: 502
effective length of database: 401,622,191
effective search space: 201614339882
effective search space used: 201614339882
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 40 (21.5 bits)
S2: 75 (34.3 bits)
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