Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001255-TA|BGIBMGA001255-PA|IPR001054|Adenylyl cyclase
class-3/4/guanylyl cyclase
(607 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
DQ008441-1|AAY27880.1| 1353|Homo sapiens adenylyl cyclase type 9... 350 7e-96
DQ005545-1|AAY21237.1| 1353|Homo sapiens adenylyl cyclase type 9... 350 7e-96
AY028959-1|AAK29464.1| 1353|Homo sapiens adenylate cyclase type ... 350 7e-96
AF036927-1|AAC24201.1| 1294|Homo sapiens adenylyl cyclase type I... 350 7e-96
AB011092-1|BAA25446.3| 1364|Homo sapiens KIAA0520 protein protein. 349 1e-95
AJ133123-1|CAB65084.1| 1353|Homo sapiens adenylyl cyclase type I... 349 2e-95
L05500-1|AAA02907.1| 839|Homo sapiens adenylyl cyclase protein. 202 3e-51
AF497517-1|AAM94374.1| 894|Homo sapiens adenylate cyclase type ... 198 6e-50
BC064923-1|AAH64923.1| 1168|Homo sapiens ADCY6 protein protein. 196 2e-49
AF250226-1|AAF82478.1| 1168|Homo sapiens adenylyl cyclase type V... 196 2e-49
AB007882-1|BAA24852.2| 1160|Homo sapiens KIAA0422 protein. 196 2e-49
X74210-1|CAA52282.1| 476|Homo sapiens adenylate cyclase protein. 193 2e-48
L21993-1|AAA64923.1| 476|Homo sapiens adenylyl cyclase protein. 193 2e-48
BC111743-1|AAI11744.1| 1091|Homo sapiens adenylate cyclase 2 (br... 193 2e-48
AF410885-1|AAP97285.1| 1091|Homo sapiens adenylyl cyclase type I... 193 2e-48
AF070583-1|AAC28647.1| 367|Homo sapiens adenylyl cyclase protein. 193 2e-48
AB028983-1|BAA83012.1| 887|Homo sapiens KIAA1060 protein protein. 193 2e-48
BC126235-1|AAI26236.1| 1144|Homo sapiens adenylate cyclase 3 pro... 191 5e-48
AK075424-1|BAC11613.1| 378|Homo sapiens protein ( Homo sapiens ... 191 5e-48
AF033861-1|AAD13403.1| 1144|Homo sapiens type III adenylyl cycla... 191 5e-48
AC012073-2|AAY14787.1| 1144|Homo sapiens unknown protein. 191 5e-48
AB011083-1|BAA25437.1| 933|Homo sapiens KIAA0511 protein protein. 191 5e-48
Z35309-1|CAA84552.1| 1251|Homo sapiens adenylyl cyclase protein. 190 9e-48
M83533-1|AAA35523.2| 675|Homo sapiens adenylyl cyclase type V p... 190 9e-48
BC117475-1|AAI17476.1| 1077|Homo sapiens adenylate cyclase 4 pro... 190 2e-47
BC117473-1|AAI17474.1| 1077|Homo sapiens adenylate cyclase 4 pro... 190 2e-47
AK056745-1|BAB71270.1| 506|Homo sapiens protein ( Homo sapiens ... 190 2e-47
AF497516-1|AAM94373.1| 1077|Homo sapiens adenylate cyclase type ... 190 2e-47
DQ104739-1|AAZ13596.1| 1120|Homo sapiens brain adenylate cyclase... 188 7e-47
AB209496-1|BAD92733.1| 1045|Homo sapiens brain adenylate cyclase... 182 3e-45
D25538-1|BAA05021.2| 1088|Homo sapiens KIAA0037 protein. 172 3e-42
BC126271-1|AAI26272.1| 1080|Homo sapiens adenylate cyclase 7 pro... 172 3e-42
S57551-1|AAB19934.2| 1073|Homo sapiens guanylate cyclase-coupled... 113 2e-24
M73489-1|AAA36655.1| 1073|Homo sapiens heat-stable enterotoxin r... 113 2e-24
L37378-1|AAA74451.1| 1108|Homo sapiens guanylyl cyclase protein. 109 4e-23
AL031387-4|CAB41303.1| 1108|Homo sapiens guanylate cyclase 2F, r... 109 4e-23
M92432-1|AAA60547.1| 1103|Homo sapiens guanylyl cyclase protein. 106 2e-22
AJ222657-1|CAA10914.1| 1103|Homo sapiens guanylyl cyclase protein. 106 2e-22
BC023017-1|AAH23017.1| 618|Homo sapiens NPR2 protein protein. 104 8e-22
AL133410-13|CAI10987.1| 1047|Homo sapiens natriuretic peptide re... 104 8e-22
AB005647-1|BAA81737.1| 1047|Homo sapiens atrial natriuretic pept... 104 8e-22
X15357-1|CAA33417.1| 1061|Homo sapiens ANP-A receptor preprotein... 100 2e-20
BC063304-1|AAH63304.1| 1061|Homo sapiens natriuretic peptide rec... 100 2e-20
AL713889-4|CAI13613.1| 1061|Homo sapiens natriuretic peptide rec... 100 2e-20
AF190631-1|AAF01340.1| 1061|Homo sapiens natriuretic peptide rec... 100 2e-20
AB010491-1|BAA31199.1| 1061|Homo sapiens natriuretic peptide A t... 100 2e-20
AF038499-1|AAD09440.2| 617|Homo sapiens soluble guanylyl cyclas... 94 1e-18
S72628-1|AAD14112.1| 415|Homo sapiens atrial natriuretic peptid... 93 3e-18
X66533-1|CAA47144.1| 619|Homo sapiens guanylate cyclase protein. 93 3e-18
BC047620-1|AAH47620.2| 619|Homo sapiens guanylate cyclase 1, so... 93 3e-18
BC015982-1|AAH15982.2| 130|Homo sapiens ADCY4 protein protein. 88 7e-17
AL713889-5|CAI13614.1| 255|Homo sapiens natriuretic peptide rec... 87 2e-16
BC039891-1|AAH39891.1| 433|Homo sapiens ADCY7 protein protein. 83 3e-15
AF020340-1|AAB94877.1| 586|Homo sapiens soluble guanylate cycla... 71 9e-12
X63282-1|CAA44921.1| 732|Homo sapiens alpha2-subunit of soluble... 66 3e-10
BC130488-1|AAI30489.1| 732|Homo sapiens guanylate cyclase 1, so... 66 3e-10
BC130484-1|AAI30485.1| 732|Homo sapiens guanylate cyclase 1, so... 66 3e-10
Y15723-1|CAA75738.1| 690|Homo sapiens soluble guanylyl cyclase ... 66 3e-10
U58855-1|AAB94794.1| 690|Homo sapiens soluble guanylate cyclase... 66 3e-10
AF233750-1|AAF64043.1| 564|Homo sapiens soluble guanylate cycla... 66 3e-10
BC028384-1|AAH28384.1| 690|Homo sapiens GUCY1A3 protein protein. 65 8e-10
X66534-1|CAA47145.1| 717|Homo sapiens guanylate cyclase protein. 59 4e-08
Z50053-1|CAA90393.1| 763|Homo sapiens alpha2i-subunit of solubl... 58 1e-07
AK126468-1|BAC86560.1| 419|Homo sapiens protein ( Homo sapiens ... 57 2e-07
AJ005282-1|CAA06466.1| 995|Homo sapiens NPR-Bi protein. 55 6e-07
U65473-1|AAD00121.1| 105|Homo sapiens adenylyl cyclase type V p... 51 1e-05
AC069008-1|AAS07467.1| 105|Homo sapiens unknown protein. 49 4e-05
AL160157-1|CAI15432.2| 385|Homo sapiens guanylate cyclase 1, so... 48 1e-04
L26921-1|AAA60366.1| 80|Homo sapiens guanyl cyclase protein. 38 0.10
AY260762-1|AAP20225.1| 3567|Homo sapiens zinc finger homeodomain... 33 2.9
AB083343-1|BAE96598.1| 3599|Homo sapiens zinc-finger homeodomain... 33 2.9
X63118-1|CAA44831.1| 153|Homo sapiens ORF protein. 32 5.1
AK131333-1|BAD18492.1| 174|Homo sapiens 9. protein. 32 5.1
>DQ008441-1|AAY27880.1| 1353|Homo sapiens adenylyl cyclase type 9
protein.
Length = 1353
Score = 350 bits (861), Expect = 7e-96
Identities = 217/603 (35%), Positives = 332/603 (55%), Gaps = 48/603 (7%)
Query: 13 SQNDMLQHRVSGYYTSSQSSLND-LHSKSRLPPPLNDQQVQ---SLQKLRKQSDLQLIRC 68
+QN +L T+SQ+SL + L K R DQ + +R+++D +
Sbjct: 672 TQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDV 731
Query: 69 VQDNARSGINYFVQPPINRFTLCFESDEMERHYRDKAHRSDDCEDLP-PTLTTSRFNTAL 127
+++++ +YF +PPIN+F+L F E+ER YR +++ + ++ P T + F++ L
Sbjct: 732 IKEDSLMK-DYFFKPPINQFSLNFLDQELERSYRT-SYQEEVMKNSPVKTFASPTFSSLL 789
Query: 128 DILVSALIFLAVSASAFV-----TCSDWWRIVGWFAFFAVIELVAIALCFYRHYLKWQTH 182
D+ +S +FL +S + F+ T + F+ ++E++++A+ +
Sbjct: 790 DVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIRMVFF----- 844
Query: 183 HDPRSVAETFHDSLKIFRKLSDWYPWHLSGGLMISLPILIVLINFSCE---NTTLPILRG 239
+ + + ++ ++ W P H G +++SLP L V + + E N P+ G
Sbjct: 845 -----LEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHVTSEYETNIHFPVFTG 899
Query: 240 EQSFYVYLLCISIVHFCNFTQMN-WLAKNTLVTLYAGVFLFVTFLGCHEVNTQYLDGDIK 298
+ I++VH+CNF Q++ W+ + + AG L + C D +
Sbjct: 900 SAAL------IAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCP-------DSSVL 946
Query: 299 LYPQFLAQNLTDYFYPNDNTSDRSENNNTLNYEGMHHKXXXXXXXXXXXXXXXXXXXXNR 358
P QN + P +++ R + + G NR
Sbjct: 947 TSPLDAVQNFSSERNPCNSSVPR-DLRRPASLIGQE-------VVLVFFLLLLLVWFLNR 998
Query: 359 EFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHKDVA 418
EFE+SYRL ++ +V A+ + ++Q+MR+QADWLL NIIP HVA+QLK + YS+NH
Sbjct: 999 EFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDSGG 1058
Query: 419 IIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAAS 478
+IFASI+NF+E Y+E+Y GKE R+LNELI DFDELL +P + +EKIKTIG+T+MAAS
Sbjct: 1059 VIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAAS 1118
Query: 479 GLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIG 538
GLN +HL L +FA EM +VVD+FN+++ F+F LR+G+N G +TAGVIG
Sbjct: 1119 GLNTAQAQDGSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIG 1178
Query: 539 TTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSVYVKGKDDMN 597
TTKL YDIWGD VNIASRMD+TGV RIQV E VLS Y+F+ RG+V VKGK M
Sbjct: 1179 TTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMK 1238
Query: 598 VYL 600
YL
Sbjct: 1239 TYL 1241
Score = 85.8 bits (203), Expect = 4e-16
Identities = 61/215 (28%), Positives = 98/215 (45%), Gaps = 27/215 (12%)
Query: 383 NMRNQADWLLHNIIPRHVADQLKNTAKYSENHK--------------DVAIIFASIINFN 428
++ Q D N + RH KN K S K +V+I+FA I+ F
Sbjct: 345 DLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFT 404
Query: 429 EMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHAS 488
+M + + +LN+L FD L E + EKI T+G + +G P+ R
Sbjct: 405 KM--SANKSAHALVGLLNDLFGRFDRLCEETK---CEKISTLGDCYYCVAGC-PEPRA-- 456
Query: 489 RGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWG 548
DH Y ++ L M K ++ F + E +R+G + G V G++G + +D+W
Sbjct: 457 ----DHAYCCIEMGLGMIKAIEQFCQEKKEM-VNMRVGVHTGTVLCGILGMRRFKFDVWS 511
Query: 549 DAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFE 583
+ VN+A+ M+ GV ++ + EA L RYE E
Sbjct: 512 NDVNLANLMEQLGVAGKVHISEATAKYLDDRYEME 546
>DQ005545-1|AAY21237.1| 1353|Homo sapiens adenylyl cyclase type 9
protein.
Length = 1353
Score = 350 bits (861), Expect = 7e-96
Identities = 217/603 (35%), Positives = 332/603 (55%), Gaps = 48/603 (7%)
Query: 13 SQNDMLQHRVSGYYTSSQSSLND-LHSKSRLPPPLNDQQVQ---SLQKLRKQSDLQLIRC 68
+QN +L T+SQ+SL + L K R DQ + +R+++D +
Sbjct: 672 TQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDV 731
Query: 69 VQDNARSGINYFVQPPINRFTLCFESDEMERHYRDKAHRSDDCEDLP-PTLTTSRFNTAL 127
+++++ +YF +PPIN+F+L F E+ER YR +++ + ++ P T + F++ L
Sbjct: 732 IKEDSLMK-DYFFKPPINQFSLNFLDQELERSYRT-SYQEEVIKNSPVKTFASPTFSSLL 789
Query: 128 DILVSALIFLAVSASAFV-----TCSDWWRIVGWFAFFAVIELVAIALCFYRHYLKWQTH 182
D+ +S +FL +S + F+ T + F+ ++E++++A+ +
Sbjct: 790 DVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIRMVFF----- 844
Query: 183 HDPRSVAETFHDSLKIFRKLSDWYPWHLSGGLMISLPILIVLINFSCE---NTTLPILRG 239
+ + + ++ ++ W P H G +++SLP L V + + E N P+ G
Sbjct: 845 -----LEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHVTSEYETNIHFPVFTG 899
Query: 240 EQSFYVYLLCISIVHFCNFTQMN-WLAKNTLVTLYAGVFLFVTFLGCHEVNTQYLDGDIK 298
+ I++VH+CNF Q++ W+ + + AG L + C D +
Sbjct: 900 SAAL------IAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCP-------DSSVL 946
Query: 299 LYPQFLAQNLTDYFYPNDNTSDRSENNNTLNYEGMHHKXXXXXXXXXXXXXXXXXXXXNR 358
P QN + P +++ R + + G NR
Sbjct: 947 TSPLDAVQNFSSERNPCNSSVPR-DLRRPASLIGQE-------VVLVFFLLLLLVWFLNR 998
Query: 359 EFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHKDVA 418
EFE+SYRL ++ +V A+ + ++Q+MR+QADWLL NIIP HVA+QLK + YS+NH
Sbjct: 999 EFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDSGG 1058
Query: 419 IIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAAS 478
+IFASI+NF+E Y+E+Y GKE R+LNELI DFDELL +P + +EKIKTIG+T+MAAS
Sbjct: 1059 VIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAAS 1118
Query: 479 GLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIG 538
GLN +HL L +FA EM +VVD+FN+++ F+F LR+G+N G +TAGVIG
Sbjct: 1119 GLNTAQAQDGSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIG 1178
Query: 539 TTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSVYVKGKDDMN 597
TTKL YDIWGD VNIASRMD+TGV RIQV E VLS Y+F+ RG+V VKGK M
Sbjct: 1179 TTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMK 1238
Query: 598 VYL 600
YL
Sbjct: 1239 TYL 1241
Score = 85.8 bits (203), Expect = 4e-16
Identities = 61/215 (28%), Positives = 98/215 (45%), Gaps = 27/215 (12%)
Query: 383 NMRNQADWLLHNIIPRHVADQLKNTAKYSENHK--------------DVAIIFASIINFN 428
++ Q D N + RH KN K S K +V+I+FA I+ F
Sbjct: 345 DLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFT 404
Query: 429 EMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHAS 488
+M + + +LN+L FD L E + EKI T+G + +G P+ R
Sbjct: 405 KM--SANKSAHALVGLLNDLFGRFDRLCEETK---CEKISTLGDCYYCVAGC-PEPRA-- 456
Query: 489 RGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWG 548
DH Y ++ L M K ++ F + E +R+G + G V G++G + +D+W
Sbjct: 457 ----DHAYCCIEMGLGMIKAIEQFCQEKKEM-VNMRVGVHTGTVLCGILGMRRFKFDVWS 511
Query: 549 DAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFE 583
+ VN+A+ M+ GV ++ + EA L RYE E
Sbjct: 512 NDVNLANLMEQLGVAGKVHISEATAKYLDDRYEME 546
>AY028959-1|AAK29464.1| 1353|Homo sapiens adenylate cyclase type 9
protein.
Length = 1353
Score = 350 bits (861), Expect = 7e-96
Identities = 217/603 (35%), Positives = 332/603 (55%), Gaps = 48/603 (7%)
Query: 13 SQNDMLQHRVSGYYTSSQSSLND-LHSKSRLPPPLNDQQVQ---SLQKLRKQSDLQLIRC 68
+QN +L T+SQ+SL + L K R DQ + +R+++D +
Sbjct: 672 TQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDV 731
Query: 69 VQDNARSGINYFVQPPINRFTLCFESDEMERHYRDKAHRSDDCEDLP-PTLTTSRFNTAL 127
+++++ +YF +PPIN+F+L F E+ER YR +++ + ++ P T + F++ L
Sbjct: 732 IKEDSLMK-DYFFKPPINQFSLNFLDQELERSYRT-SYQEEVIKNSPVKTFASPTFSSLL 789
Query: 128 DILVSALIFLAVSASAFV-----TCSDWWRIVGWFAFFAVIELVAIALCFYRHYLKWQTH 182
D+ +S +FL +S + F+ T + F+ ++E++++A+ +
Sbjct: 790 DVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIRMVFF----- 844
Query: 183 HDPRSVAETFHDSLKIFRKLSDWYPWHLSGGLMISLPILIVLINFSCE---NTTLPILRG 239
+ + + ++ ++ W P H G +++SLP L V + + E N P+ G
Sbjct: 845 -----LEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHVTSEYETNIHFPVFTG 899
Query: 240 EQSFYVYLLCISIVHFCNFTQMN-WLAKNTLVTLYAGVFLFVTFLGCHEVNTQYLDGDIK 298
+ I++VH+CNF Q++ W+ + + AG L + C D +
Sbjct: 900 SAAL------IAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCP-------DSSVL 946
Query: 299 LYPQFLAQNLTDYFYPNDNTSDRSENNNTLNYEGMHHKXXXXXXXXXXXXXXXXXXXXNR 358
P QN + P +++ R + + G NR
Sbjct: 947 TSPLDAVQNFSSERNPCNSSVPR-DLRRPASLIGQE-------VVLVFFLLLLLVWFLNR 998
Query: 359 EFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHKDVA 418
EFE+SYRL ++ +V A+ + ++Q+MR+QADWLL NIIP HVA+QLK + YS+NH
Sbjct: 999 EFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDSGG 1058
Query: 419 IIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAAS 478
+IFASI+NF+E Y+E+Y GKE R+LNELI DFDELL +P + +EKIKTIG+T+MAAS
Sbjct: 1059 VIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAAS 1118
Query: 479 GLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIG 538
GLN +HL L +FA EM +VVD+FN+++ F+F LR+G+N G +TAGVIG
Sbjct: 1119 GLNTAQAQDGSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIG 1178
Query: 539 TTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSVYVKGKDDMN 597
TTKL YDIWGD VNIASRMD+TGV RIQV E VLS Y+F+ RG+V VKGK M
Sbjct: 1179 TTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMK 1238
Query: 598 VYL 600
YL
Sbjct: 1239 TYL 1241
Score = 85.8 bits (203), Expect = 4e-16
Identities = 61/215 (28%), Positives = 98/215 (45%), Gaps = 27/215 (12%)
Query: 383 NMRNQADWLLHNIIPRHVADQLKNTAKYSENHK--------------DVAIIFASIINFN 428
++ Q D N + RH KN K S K +V+I+FA I+ F
Sbjct: 345 DLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFT 404
Query: 429 EMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHAS 488
+M + + +LN+L FD L E + EKI T+G + +G P+ R
Sbjct: 405 KM--SANKSAHALVGLLNDLFGRFDRLCEETK---CEKISTLGDCYYCVAGC-PEPRA-- 456
Query: 489 RGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWG 548
DH Y ++ L M K ++ F + E +R+G + G V G++G + +D+W
Sbjct: 457 ----DHAYCCIEMGLGMIKAIEQFCQEKKEM-VNMRVGVHTGTVLCGILGMRRFKFDVWS 511
Query: 549 DAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFE 583
+ VN+A+ M+ GV ++ + EA L RYE E
Sbjct: 512 NDVNLANLMEQLGVAGKVHISEATAKYLDDRYEME 546
>AF036927-1|AAC24201.1| 1294|Homo sapiens adenylyl cyclase type IX
protein.
Length = 1294
Score = 350 bits (861), Expect = 7e-96
Identities = 217/603 (35%), Positives = 332/603 (55%), Gaps = 48/603 (7%)
Query: 13 SQNDMLQHRVSGYYTSSQSSLND-LHSKSRLPPPLNDQQVQ---SLQKLRKQSDLQLIRC 68
+QN +L T+SQ+SL + L K R DQ + +R+++D +
Sbjct: 672 TQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDV 731
Query: 69 VQDNARSGINYFVQPPINRFTLCFESDEMERHYRDKAHRSDDCEDLP-PTLTTSRFNTAL 127
+++++ +YF +PPIN+F+L F E+ER YR +++ + ++ P T + F++ L
Sbjct: 732 IKEDSLMK-DYFFKPPINQFSLNFLDQELERSYRT-SYQEEVIKNSPVKTFASPTFSSLL 789
Query: 128 DILVSALIFLAVSASAFV-----TCSDWWRIVGWFAFFAVIELVAIALCFYRHYLKWQTH 182
D+ +S +FL +S + F+ T + F+ ++E++++A+ +
Sbjct: 790 DVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIRMVFF----- 844
Query: 183 HDPRSVAETFHDSLKIFRKLSDWYPWHLSGGLMISLPILIVLINFSCE---NTTLPILRG 239
+ + + ++ ++ W P H G +++SLP L V + + E N P+ G
Sbjct: 845 -----LEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHVTSEYETNIHFPVFTG 899
Query: 240 EQSFYVYLLCISIVHFCNFTQMN-WLAKNTLVTLYAGVFLFVTFLGCHEVNTQYLDGDIK 298
+ I++VH+CNF Q++ W+ + + AG L + C D +
Sbjct: 900 SAAL------IAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCP-------DSSVL 946
Query: 299 LYPQFLAQNLTDYFYPNDNTSDRSENNNTLNYEGMHHKXXXXXXXXXXXXXXXXXXXXNR 358
P QN + P +++ R + + G NR
Sbjct: 947 TSPLDAVQNFSSERNPCNSSVPR-DLRRPASLIGQE-------VVLVFFLLLLLVWFLNR 998
Query: 359 EFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHKDVA 418
EFE+SYRL ++ +V A+ + ++Q+MR+QADWLL NIIP HVA+QLK + YS+NH
Sbjct: 999 EFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDSGG 1058
Query: 419 IIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAAS 478
+IFASI+NF+E Y+E+Y GKE R+LNELI DFDELL +P + +EKIKTIG+T+MAAS
Sbjct: 1059 VIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAAS 1118
Query: 479 GLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIG 538
GLN +HL L +FA EM +VVD+FN+++ F+F LR+G+N G +TAGVIG
Sbjct: 1119 GLNTAQAQDGSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIG 1178
Query: 539 TTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSVYVKGKDDMN 597
TTKL YDIWGD VNIASRMD+TGV RIQV E VLS Y+F+ RG+V VKGK M
Sbjct: 1179 TTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMK 1238
Query: 598 VYL 600
YL
Sbjct: 1239 TYL 1241
Score = 85.8 bits (203), Expect = 4e-16
Identities = 61/215 (28%), Positives = 98/215 (45%), Gaps = 27/215 (12%)
Query: 383 NMRNQADWLLHNIIPRHVADQLKNTAKYSENHK--------------DVAIIFASIINFN 428
++ Q D N + RH KN K S K +V+I+FA I+ F
Sbjct: 345 DLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFT 404
Query: 429 EMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHAS 488
+M + + +LN+L FD L E + EKI T+G + +G P+ R
Sbjct: 405 KM--SANKSAHALVGLLNDLFGRFDRLCEETK---CEKISTLGDCYYCVAGC-PEPRA-- 456
Query: 489 RGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWG 548
DH Y ++ L M K ++ F + E +R+G + G V G++G + +D+W
Sbjct: 457 ----DHAYCCIEMGLGMIKAIEQFCQEKKEM-VNMRVGVHTGTVLCGILGMRRFKFDVWS 511
Query: 549 DAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFE 583
+ VN+A+ M+ GV ++ + EA L RYE E
Sbjct: 512 NDVNLANLMEQLGVAGKVHISEATAKYLDDRYEME 546
>AB011092-1|BAA25446.3| 1364|Homo sapiens KIAA0520 protein protein.
Length = 1364
Score = 349 bits (859), Expect = 1e-95
Identities = 217/603 (35%), Positives = 331/603 (54%), Gaps = 48/603 (7%)
Query: 13 SQNDMLQHRVSGYYTSSQSSLND-LHSKSRLPPPLNDQQVQ---SLQKLRKQSDLQLIRC 68
+QN +L T+SQ+SL + L K R DQ + +R+++D +
Sbjct: 683 TQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDV 742
Query: 69 VQDNARSGINYFVQPPINRFTLCFESDEMERHYRDKAHRSDDCEDLP-PTLTTSRFNTAL 127
+++++ +YF +PPIN+F+L F E+ER YR +++ + ++ P T + F++ L
Sbjct: 743 IKEDSLMK-DYFFKPPINQFSLNFLDQELERSYRT-SYQEEVIKNSPVKTFASPTFSSLL 800
Query: 128 DILVSALIFLAVSASAFV-----TCSDWWRIVGWFAFFAVIELVAIALCFYRHYLKWQTH 182
D+ +S +FL +S + F+ T + F+ ++E++++A+ +
Sbjct: 801 DVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIRMVFF----- 855
Query: 183 HDPRSVAETFHDSLKIFRKLSDWYPWHLSGGLMISLPILIVLINFSCE---NTTLPILRG 239
+ + + ++ ++ W P H G +++SLP L V + + E N P+ G
Sbjct: 856 -----LEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHVTSEYETNIHFPVFTG 910
Query: 240 EQSFYVYLLCISIVHFCNFTQMN-WLAKNTLVTLYAGVFLFVTFLGCHEVNTQYLDGDIK 298
+ I++VH+CNF Q++ W+ + + AG L + C D +
Sbjct: 911 SAAL------IAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCP-------DSSVL 957
Query: 299 LYPQFLAQNLTDYFYPNDNTSDRSENNNTLNYEGMHHKXXXXXXXXXXXXXXXXXXXXNR 358
P QN + P +++ R + + G NR
Sbjct: 958 TSPLDAVQNFSSERNPCNSSVPR-DLRRPASLIGQE-------VVLVFFLLLLLVWFLNR 1009
Query: 359 EFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHKDVA 418
EFE+SYRL ++ +V A+ + ++Q+MR+QADWLL NIIP HVA+QLK + YS+NH
Sbjct: 1010 EFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDSGG 1069
Query: 419 IIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAAS 478
+IFASI+NF+E Y+E+Y GKE R+LNELI DFDELL +P + +EKIKTIG+T+MAAS
Sbjct: 1070 VIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAAS 1129
Query: 479 GLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIG 538
GLN +HL L +FA EM +VVD+FN ++ F+F LR+G+N G +TAGVIG
Sbjct: 1130 GLNTAQAQDGSHPQEHLQILFEFAKEMMRVVDDFNSNMLWFNFKLRVGFNHGPLTAGVIG 1189
Query: 539 TTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSVYVKGKDDMN 597
TTKL YDIWGD VNIASRMD+TGV RIQV E VLS Y+F+ RG+V VKGK M
Sbjct: 1190 TTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMK 1249
Query: 598 VYL 600
YL
Sbjct: 1250 TYL 1252
Score = 85.8 bits (203), Expect = 4e-16
Identities = 61/215 (28%), Positives = 98/215 (45%), Gaps = 27/215 (12%)
Query: 383 NMRNQADWLLHNIIPRHVADQLKNTAKYSENHK--------------DVAIIFASIINFN 428
++ Q D N + RH KN K S K +V+I+FA I+ F
Sbjct: 356 DLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFT 415
Query: 429 EMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHAS 488
+M + + +LN+L FD L E + EKI T+G + +G P+ R
Sbjct: 416 KM--SANKSAHALVGLLNDLFGRFDRLCEETK---CEKISTLGDCYYCVAGC-PEPRA-- 467
Query: 489 RGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWG 548
DH Y ++ L M K ++ F + E +R+G + G V G++G + +D+W
Sbjct: 468 ----DHAYCCIEMGLGMIKAIEQFCQEKKEM-VNMRVGVHTGTVLCGILGMRRFKFDVWS 522
Query: 549 DAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFE 583
+ VN+A+ M+ GV ++ + EA L RYE E
Sbjct: 523 NDVNLANLMEQLGVAGKVHISEATAKYLDDRYEME 557
>AJ133123-1|CAB65084.1| 1353|Homo sapiens adenylyl cyclase type IX
protein.
Length = 1353
Score = 349 bits (858), Expect = 2e-95
Identities = 217/603 (35%), Positives = 331/603 (54%), Gaps = 48/603 (7%)
Query: 13 SQNDMLQHRVSGYYTSSQSSLND-LHSKSRLPPPLNDQQVQ---SLQKLRKQSDLQLIRC 68
+QN +L T+SQ+SL + L K R DQ + +R+++D +
Sbjct: 672 TQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDV 731
Query: 69 VQDNARSGINYFVQPPINRFTLCFESDEMERHYRDKAHRSDDCEDLP-PTLTTSRFNTAL 127
+++++ +YF +PPIN+F+L F E+ER YR +++ + ++ P T + F++ L
Sbjct: 732 IKEDSLMK-DYFFKPPINQFSLNFLDQELERSYRT-SYQEEVIKNSPVKTFASPTFSSLL 789
Query: 128 DILVSALIFLAVSASAFV-----TCSDWWRIVGWFAFFAVIELVAIALCFYRHYLKWQTH 182
D+ +S +FL +S + F+ T + F+ ++E++++A+ +
Sbjct: 790 DVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIRMVFF----- 844
Query: 183 HDPRSVAETFHDSLKIFRKLSDWYPWHLSGGLMISLPILIVLINFSCE---NTTLPILRG 239
+ + + ++ ++ W P H G +++SLP L V + + E N P+ G
Sbjct: 845 -----LEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHATSEYETNIHFPVFTG 899
Query: 240 EQSFYVYLLCISIVHFCNFTQMN-WLAKNTLVTLYAGVFLFVTFLGCHEVNTQYLDGDIK 298
+ I++VH+CNF Q++ W+ + + AG L + C D +
Sbjct: 900 SAAL------IAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCP-------DSSVL 946
Query: 299 LYPQFLAQNLTDYFYPNDNTSDRSENNNTLNYEGMHHKXXXXXXXXXXXXXXXXXXXXNR 358
P QN + P +++ R + + G NR
Sbjct: 947 TSPLDAVQNFSSERNPCNSSVPR-DLRRPASLIGQE-------VVLVFFLLLLLVWFLNR 998
Query: 359 EFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHKDVA 418
EFE+SYRL ++ +V A+ + ++Q+MR+QADWLL NIIP HVA+QLK + YS+NH
Sbjct: 999 EFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDSGG 1058
Query: 419 IIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAAS 478
+IFASI+NF+E Y+E+Y GKE R+LNELI DFDELL +P + +EKIKTIG+T+MAAS
Sbjct: 1059 VIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAAS 1118
Query: 479 GLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIG 538
GLN +HL L +FA EM +VVD+FN ++ F+F LR+G+N G +TAGVIG
Sbjct: 1119 GLNTAQAQDGSHPQEHLQILFEFAKEMMRVVDDFNSNMLWFNFKLRVGFNHGPLTAGVIG 1178
Query: 539 TTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSVYVKGKDDMN 597
TTKL YDIWGD VNIASRMD+TGV RIQV E VLS Y+F+ RG+V VKGK M
Sbjct: 1179 TTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMK 1238
Query: 598 VYL 600
YL
Sbjct: 1239 TYL 1241
Score = 82.6 bits (195), Expect = 4e-15
Identities = 60/215 (27%), Positives = 97/215 (45%), Gaps = 27/215 (12%)
Query: 383 NMRNQADWLLHNIIPRHVADQLKNTAKYSENHK--------------DVAIIFASIINFN 428
++ Q D N + RH KN K S K +V+I+FA I+ F
Sbjct: 345 DLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFT 404
Query: 429 EMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHAS 488
+M + + +LN+L FD L E + EKI T+G + +G P+ R
Sbjct: 405 KM--SANKSAHALVGLLNDLFGRFDRLCEETK---CEKISTLGDCYYCVAGC-PEPRA-- 456
Query: 489 RGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWG 548
DH Y ++ L M K ++ F + E +R+G + V G++G + +D+W
Sbjct: 457 ----DHAYCCIEMGLGMIKAIEQFCQEKKEM-VNMRVGVHTRTVLCGILGMRRFKFDVWS 511
Query: 549 DAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFE 583
+ VN+A+ M+ GV ++ + EA L RYE E
Sbjct: 512 NDVNLANLMEQLGVAGKVHISEATAKYLDDRYEME 546
>L05500-1|AAA02907.1| 839|Homo sapiens adenylyl cyclase protein.
Length = 839
Score = 202 bits (493), Expect = 3e-51
Identities = 114/258 (44%), Positives = 155/258 (60%), Gaps = 10/258 (3%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-----KNTAKYSE 412
R+ +I RL + A +++ ++ ++ +L N++P HVA +N Y +
Sbjct: 523 RQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQ 582
Query: 413 NHKDVAIIFASIINFNEMYDE--SYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
++ V ++FASI NFN+ Y E G E LR+LNE+IADFDEL+E+ ++ +EKIKTI
Sbjct: 583 SYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTI 642
Query: 471 GSTFMAASGLNPDL-RHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
GST+MAA GL P A + HL L DFA+EM V+D N+ + DF+LR+G N
Sbjct: 643 GSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFDVLDEINYQSYN-DFVLRVGINV 701
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-SARYEFEPRGSV 588
G V AGVIG + YDIWG+ VN+ASRMDSTGV RIQV E +L Y F RG V
Sbjct: 702 GPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPYHFVCRGKV 761
Query: 589 YVKGKDDMNVYLLVGKKD 606
VKGK +M Y L G+ D
Sbjct: 762 SVKGKGEMLTYFLEGRTD 779
Score = 93.5 bits (222), Expect = 2e-18
Identities = 52/175 (29%), Positives = 91/175 (52%), Gaps = 13/175 (7%)
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
Y + H +V+I+FA I+ F + S +E +++LNEL FDEL H +IK
Sbjct: 15 YIQRHDNVSILFADIVGFTGL--ASQCTAQELVKLLNELFGKFDELATE---NHCRRIKI 69
Query: 470 IGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
+G + SGL ++ DH + ++ L+M + + + E D +R+G +
Sbjct: 70 LGDCYYCVSGL-------TQPKTDHAHCCVEMGLDMIDTITSVA-EATEVDLNMRVGLHT 121
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP 584
G V GV+G K YD+W + V +A+ M++ G+P ++ + + + L+ YE EP
Sbjct: 122 GRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEP 176
>AF497517-1|AAM94374.1| 894|Homo sapiens adenylate cyclase type V
protein.
Length = 894
Score = 198 bits (482), Expect = 6e-50
Identities = 115/254 (45%), Positives = 158/254 (62%), Gaps = 11/254 (4%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-----KNTAKYSE 412
++ E + RL F + A +K+ ++ ++ LLHNI+P+ VA +N Y +
Sbjct: 639 QQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQ 698
Query: 413 NHKDVAIIFASIINFNEMYDE--SYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
+ + VA++FASI NF+E Y E + +G E LR+LNE+IADFDE++ +F+ +EKIKTI
Sbjct: 699 SCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTI 758
Query: 471 GSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFG 530
GST+MAASGLN D + G H+ L DFA+++ + N F +F ++IG N G
Sbjct: 759 GSTYMAASGLN-DSTYDKVGK-THIKALADFAMKLMDQMKYINEHSFN-NFQMKIGLNIG 815
Query: 531 DVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSVY 589
V AGVIG K YDIWG+ VN+ASRMDSTGVP RIQV VL+A Y+ E RG V
Sbjct: 816 PVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVK 875
Query: 590 VKGKDDMNVYLLVG 603
VKGK +M Y L G
Sbjct: 876 VKGKGEMMTYFLNG 889
Score = 93.5 bits (222), Expect = 2e-18
Identities = 68/235 (28%), Positives = 116/235 (49%), Gaps = 24/235 (10%)
Query: 361 EISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKN--TAK--------- 409
E+S R +F + + Q Q + LL +++PRHVA ++K AK
Sbjct: 34 EVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKI 93
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
Y + H +V+I+FA I F + S +E + LNEL A FD+L H +IK
Sbjct: 94 YIQKHDNVSILFADIEGFTSL--ASQCTAQELVMTLNELFARFDKLAAE---NHCLRIKI 148
Query: 470 IGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
+G + SGL P+ R DH + ++ ++M + + + ++ + +R+G +
Sbjct: 149 LGDCYYCVSGL-PEARA------DHAHCCVEMGMDMIEAI-SLVREVTGVNVNMRVGIHS 200
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP 584
G V GV+G K +D+W + V +A+ M++ G RI + +A + L+ YE EP
Sbjct: 201 GRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEP 255
>BC064923-1|AAH64923.1| 1168|Homo sapiens ADCY6 protein protein.
Length = 1168
Score = 196 bits (478), Expect = 2e-49
Identities = 112/254 (44%), Positives = 159/254 (62%), Gaps = 11/254 (4%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-----KNTAKYSE 412
++ E + RL F + A +K+ ++ ++ LLHNI+P+ VA +N Y +
Sbjct: 914 QQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQ 973
Query: 413 NHKDVAIIFASIINFNEMYDE--SYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
+ + VA++FASI NF+E Y E + +G E LR+LNE+IADFDE++ +F+ +EKIKTI
Sbjct: 974 SCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTI 1033
Query: 471 GSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFG 530
GST+MAASGLN + G H+ L D+A+ + + + + N F +F ++IG N G
Sbjct: 1034 GSTYMAASGLNAST-YDQVGR-SHITALADYAMRLMEQMKHINEHSFN-NFQMKIGLNMG 1090
Query: 531 DVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSVY 589
V AGVIG K YDIWG+ VN++SRMDSTGVP RIQV VL+A+ Y+ E RG V
Sbjct: 1091 PVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVK 1150
Query: 590 VKGKDDMNVYLLVG 603
VKGK +M Y L G
Sbjct: 1151 VKGKGEMTTYFLNG 1164
Score = 96.7 bits (230), Expect = 2e-19
Identities = 74/258 (28%), Positives = 131/258 (50%), Gaps = 29/258 (11%)
Query: 361 EISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLK---NTAK-------- 409
E+S R +F + + +Q+ Q + LL +++P+HVA ++K NT K
Sbjct: 311 EVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKI 370
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
Y + H +V+I+FA I F + S +E + LNEL A FD+L H +IK
Sbjct: 371 YIQKHDNVSILFADIEGFTSL--ASQCTAQELVMTLNELFARFDKLAAE---NHCLRIKI 425
Query: 470 IGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
+G + SGL P+ R DH + ++ ++M + + + ++ + +R+G +
Sbjct: 426 LGDCYYCVSGL-PEARA------DHAHCCVEMGVDMIEAI-SLVREVTGVNVNMRVGIHS 477
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP-RG-- 586
G V GV+G K +D+W + V +A+ M++ G RI + A + L+ YE EP RG
Sbjct: 478 GRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGE 537
Query: 587 -SVYVKGKDDMNVYLLVG 603
+ Y+K + + +L++G
Sbjct: 538 RNAYLK-EQHIETFLILG 554
>AF250226-1|AAF82478.1| 1168|Homo sapiens adenylyl cyclase type VI
protein.
Length = 1168
Score = 196 bits (478), Expect = 2e-49
Identities = 112/254 (44%), Positives = 159/254 (62%), Gaps = 11/254 (4%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-----KNTAKYSE 412
++ E + RL F + A +K+ ++ ++ LLHNI+P+ VA +N Y +
Sbjct: 914 QQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQ 973
Query: 413 NHKDVAIIFASIINFNEMYDE--SYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
+ + VA++FASI NF+E Y E + +G E LR+LNE+IADFDE++ +F+ +EKIKTI
Sbjct: 974 SCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTI 1033
Query: 471 GSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFG 530
GST+MAASGLN + G H+ L D+A+ + + + + N F +F ++IG N G
Sbjct: 1034 GSTYMAASGLNAST-YDQVGR-SHITALADYAMRLMEQMKHINEHSFN-NFQMKIGLNMG 1090
Query: 531 DVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSVY 589
V AGVIG K YDIWG+ VN++SRMDSTGVP RIQV VL+A+ Y+ E RG V
Sbjct: 1091 PVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVK 1150
Query: 590 VKGKDDMNVYLLVG 603
VKGK +M Y L G
Sbjct: 1151 VKGKGEMTTYFLNG 1164
Score = 96.7 bits (230), Expect = 2e-19
Identities = 74/258 (28%), Positives = 131/258 (50%), Gaps = 29/258 (11%)
Query: 361 EISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLK---NTAK-------- 409
E+S R +F + + +Q+ Q + LL +++P+HVA ++K NT K
Sbjct: 311 EVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKI 370
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
Y + H +V+I+FA I F + S +E + LNEL A FD+L H +IK
Sbjct: 371 YIQKHDNVSILFADIEGFTSL--ASQCTAQELVMTLNELFARFDKLAAE---NHCLRIKI 425
Query: 470 IGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
+G + SGL P+ R DH + ++ ++M + + + ++ + +R+G +
Sbjct: 426 LGDCYYCVSGL-PEARA------DHAHCCVEMGVDMIEAI-SLVREVTGVNVNMRVGIHS 477
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP-RG-- 586
G V GV+G K +D+W + V +A+ M++ G RI + A + L+ YE EP RG
Sbjct: 478 GRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGE 537
Query: 587 -SVYVKGKDDMNVYLLVG 603
+ Y+K + + +L++G
Sbjct: 538 RNAYLK-EQHIETFLILG 554
>AB007882-1|BAA24852.2| 1160|Homo sapiens KIAA0422 protein.
Length = 1160
Score = 196 bits (478), Expect = 2e-49
Identities = 112/254 (44%), Positives = 159/254 (62%), Gaps = 11/254 (4%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-----KNTAKYSE 412
++ E + RL F + A +K+ ++ ++ LLHNI+P+ VA +N Y +
Sbjct: 906 QQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQ 965
Query: 413 NHKDVAIIFASIINFNEMYDE--SYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
+ + VA++FASI NF+E Y E + +G E LR+LNE+IADFDE++ +F+ +EKIKTI
Sbjct: 966 SCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTI 1025
Query: 471 GSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFG 530
GST+MAASGLN + G H+ L D+A+ + + + + N F +F ++IG N G
Sbjct: 1026 GSTYMAASGLNAST-YDQVGR-SHITALADYAMRLMEQMKHINEHSFN-NFQMKIGLNMG 1082
Query: 531 DVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSVY 589
V AGVIG K YDIWG+ VN++SRMDSTGVP RIQV VL+A+ Y+ E RG V
Sbjct: 1083 PVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVK 1142
Query: 590 VKGKDDMNVYLLVG 603
VKGK +M Y L G
Sbjct: 1143 VKGKGEMTTYFLNG 1156
Score = 96.7 bits (230), Expect = 2e-19
Identities = 74/258 (28%), Positives = 131/258 (50%), Gaps = 29/258 (11%)
Query: 361 EISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLK---NTAK-------- 409
E+S R +F + + +Q+ Q + LL +++P+HVA ++K NT K
Sbjct: 356 EVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKI 415
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
Y + H +V+I+FA I F + S +E + LNEL A FD+L H +IK
Sbjct: 416 YIQKHDNVSILFADIEGFTSL--ASQCTAQELVMTLNELFARFDKLAAE---NHCLRIKI 470
Query: 470 IGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
+G + SGL P+ R DH + ++ ++M + + + ++ + +R+G +
Sbjct: 471 LGDCYYCVSGL-PEARA------DHAHCCVEMGVDMIEAI-SLVREVTGVNVNMRVGIHS 522
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP-RG-- 586
G V GV+G K +D+W + V +A+ M++ G RI + A + L+ YE EP RG
Sbjct: 523 GRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGE 582
Query: 587 -SVYVKGKDDMNVYLLVG 603
+ Y+K + + +L++G
Sbjct: 583 RNAYLK-EQHIETFLILG 599
>X74210-1|CAA52282.1| 476|Homo sapiens adenylate cyclase protein.
Length = 476
Score = 193 bits (470), Expect = 2e-48
Identities = 113/256 (44%), Positives = 154/256 (60%), Gaps = 13/256 (5%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQ-----LKNTAKYSE 412
R+ E RL F ++++ ++ M N LL N++P HVA+ LKN Y +
Sbjct: 207 RQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQ 266
Query: 413 NHKDVAIIFASIINFNEMYDESYL--KGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
++ V ++FASI +F E Y ES + +G E LR+LNE+IADFD+LL +P+F VEKIKTI
Sbjct: 267 SYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTI 326
Query: 471 GSTFMAASGLN--PDLRHASRGT--YDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIG 526
GST+MAA+GL+ P H+ Y H+ +++FA + +D N F DF LR+G
Sbjct: 327 GSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFN-DFKLRVG 385
Query: 527 YNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-SARYEFEPR 585
N G V AGVIG K YDIWG+ VN+ASRMDSTGV +IQV E VL + Y R
Sbjct: 386 INHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCR 445
Query: 586 GSVYVKGKDDMNVYLL 601
G + VKGK D+ Y +
Sbjct: 446 GIINVKGKGDLKTYFV 461
>L21993-1|AAA64923.1| 476|Homo sapiens adenylyl cyclase protein.
Length = 476
Score = 193 bits (470), Expect = 2e-48
Identities = 113/256 (44%), Positives = 154/256 (60%), Gaps = 13/256 (5%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQ-----LKNTAKYSE 412
R+ E RL F ++++ ++ M N LL N++P HVA+ LKN Y +
Sbjct: 207 RQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQ 266
Query: 413 NHKDVAIIFASIINFNEMYDESYL--KGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
++ V ++FASI +F E Y ES + +G E LR+LNE+IADFD+LL +P+F VEKIKTI
Sbjct: 267 SYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTI 326
Query: 471 GSTFMAASGLN--PDLRHASRGT--YDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIG 526
GST+MAA+GL+ P H+ Y H+ +++FA + +D N F DF LR+G
Sbjct: 327 GSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFN-DFKLRVG 385
Query: 527 YNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-SARYEFEPR 585
N G V AGVIG K YDIWG+ VN+ASRMDSTGV +IQV E VL + Y R
Sbjct: 386 INHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCR 445
Query: 586 GSVYVKGKDDMNVYLL 601
G + VKGK D+ Y +
Sbjct: 446 GIINVKGKGDLKTYFV 461
>BC111743-1|AAI11744.1| 1091|Homo sapiens adenylate cyclase 2 (brain)
protein.
Length = 1091
Score = 193 bits (470), Expect = 2e-48
Identities = 113/256 (44%), Positives = 154/256 (60%), Gaps = 13/256 (5%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQ-----LKNTAKYSE 412
R+ E RL F ++++ ++ M N LL N++P HVA+ LKN Y +
Sbjct: 822 RQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQ 881
Query: 413 NHKDVAIIFASIINFNEMYDESYL--KGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
++ V ++FASI +F E Y ES + +G E LR+LNE+IADFD+LL +P+F VEKIKTI
Sbjct: 882 SYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTI 941
Query: 471 GSTFMAASGLN--PDLRHASRGT--YDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIG 526
GST+MAA+GL+ P H+ Y H+ +++FA + +D N F DF LR+G
Sbjct: 942 GSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFN-DFKLRVG 1000
Query: 527 YNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-SARYEFEPR 585
N G V AGVIG K YDIWG+ VN+ASRMDSTGV +IQV E VL + Y R
Sbjct: 1001 INHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCR 1060
Query: 586 GSVYVKGKDDMNVYLL 601
G + VKGK D+ Y +
Sbjct: 1061 GIINVKGKGDLKTYFV 1076
Score = 81.4 bits (192), Expect = 8e-15
Identities = 52/187 (27%), Positives = 90/187 (48%), Gaps = 17/187 (9%)
Query: 401 ADQLKNTAK----YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELL 456
A Q++NT Y + H +V+I++A I+ F + + E + +LNEL FD++
Sbjct: 269 AGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDC--SPGELVHMLNELFGKFDQIA 326
Query: 457 ERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDL 516
+ + +IK +G + SGL L + H + L+M + + D
Sbjct: 327 KENECM---RIKILGDCYYCVSGLPISLPN-------HAKNCVKMGLDMCEAIKKVR-DA 375
Query: 517 FEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL 576
D +R+G + G+V GVIG K YD+W V +A+ M++ GVP R+ + + L
Sbjct: 376 TGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHL 435
Query: 577 SARYEFE 583
+ Y+ E
Sbjct: 436 NGAYKVE 442
>AF410885-1|AAP97285.1| 1091|Homo sapiens adenylyl cyclase type II
protein.
Length = 1091
Score = 193 bits (470), Expect = 2e-48
Identities = 113/256 (44%), Positives = 154/256 (60%), Gaps = 13/256 (5%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQ-----LKNTAKYSE 412
R+ E RL F ++++ ++ M N LL N++P HVA+ LKN Y +
Sbjct: 822 RQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQ 881
Query: 413 NHKDVAIIFASIINFNEMYDESYL--KGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
++ V ++FASI +F E Y ES + +G E LR+LNE+IADFD+LL +P+F VEKIKTI
Sbjct: 882 SYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTI 941
Query: 471 GSTFMAASGLN--PDLRHASRGT--YDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIG 526
GST+MAA+GL+ P H+ Y H+ +++FA + +D N F DF LR+G
Sbjct: 942 GSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFN-DFKLRVG 1000
Query: 527 YNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-SARYEFEPR 585
N G V AGVIG K YDIWG+ VN+ASRMDSTGV +IQV E VL + Y R
Sbjct: 1001 INHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCR 1060
Query: 586 GSVYVKGKDDMNVYLL 601
G + VKGK D+ Y +
Sbjct: 1061 GIINVKGKGDLKTYFV 1076
Score = 81.4 bits (192), Expect = 8e-15
Identities = 52/187 (27%), Positives = 90/187 (48%), Gaps = 17/187 (9%)
Query: 401 ADQLKNTAK----YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELL 456
A Q++NT Y + H +V+I++A I+ F + + E + +LNEL FD++
Sbjct: 269 AGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDC--SPGELVHMLNELFGKFDQIA 326
Query: 457 ERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDL 516
+ + +IK +G + SGL L + H + L+M + + D
Sbjct: 327 KENECM---RIKILGDCYYCVSGLPISLPN-------HAKNCVKMGLDMCEAIKKVR-DA 375
Query: 517 FEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL 576
D +R+G + G+V GVIG K YD+W V +A+ M++ GVP R+ + + L
Sbjct: 376 TGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHL 435
Query: 577 SARYEFE 583
+ Y+ E
Sbjct: 436 NGAYKVE 442
>AF070583-1|AAC28647.1| 367|Homo sapiens adenylyl cyclase protein.
Length = 367
Score = 193 bits (470), Expect = 2e-48
Identities = 113/256 (44%), Positives = 154/256 (60%), Gaps = 13/256 (5%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQ-----LKNTAKYSE 412
R+ E RL F ++++ ++ M N LL N++P HVA+ LKN Y +
Sbjct: 98 RQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQ 157
Query: 413 NHKDVAIIFASIINFNEMYDESYL--KGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
++ V ++FASI +F E Y ES + +G E LR+LNE+IADFD+LL +P+F VEKIKTI
Sbjct: 158 SYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTI 217
Query: 471 GSTFMAASGLN--PDLRHASRGT--YDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIG 526
GST+MAA+GL+ P H+ Y H+ +++FA + +D N F DF LR+G
Sbjct: 218 GSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFN-DFKLRVG 276
Query: 527 YNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-SARYEFEPR 585
N G V AGVIG K YDIWG+ VN+ASRMDSTGV +IQV E VL + Y R
Sbjct: 277 INHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCR 336
Query: 586 GSVYVKGKDDMNVYLL 601
G + VKGK D+ Y +
Sbjct: 337 GIINVKGKGDLKTYFV 352
>AB028983-1|BAA83012.1| 887|Homo sapiens KIAA1060 protein protein.
Length = 887
Score = 193 bits (470), Expect = 2e-48
Identities = 113/256 (44%), Positives = 154/256 (60%), Gaps = 13/256 (5%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQ-----LKNTAKYSE 412
R+ E RL F ++++ ++ M N LL N++P HVA+ LKN Y +
Sbjct: 618 RQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQ 677
Query: 413 NHKDVAIIFASIINFNEMYDESYL--KGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
++ V ++FASI +F E Y ES + +G E LR+LNE+IADFD+LL +P+F VEKIKTI
Sbjct: 678 SYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTI 737
Query: 471 GSTFMAASGLN--PDLRHASRGT--YDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIG 526
GST+MAA+GL+ P H+ Y H+ +++FA + +D N F DF LR+G
Sbjct: 738 GSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFN-DFKLRVG 796
Query: 527 YNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-SARYEFEPR 585
N G V AGVIG K YDIWG+ VN+ASRMDSTGV +IQV E VL + Y R
Sbjct: 797 INHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCR 856
Query: 586 GSVYVKGKDDMNVYLL 601
G + VKGK D+ Y +
Sbjct: 857 GIINVKGKGDLKTYFV 872
Score = 81.4 bits (192), Expect = 8e-15
Identities = 52/187 (27%), Positives = 90/187 (48%), Gaps = 17/187 (9%)
Query: 401 ADQLKNTAK----YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELL 456
A Q++NT Y + H +V+I++A I+ F + + E + +LNEL FD++
Sbjct: 65 AGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDC--SPGELVHMLNELFGKFDQIA 122
Query: 457 ERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDL 516
+ + +IK +G + SGL L + H + L+M + + D
Sbjct: 123 KENECM---RIKILGDCYYCVSGLPISLPN-------HAKNCVKMGLDMCEAIKKVR-DA 171
Query: 517 FEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL 576
D +R+G + G+V GVIG K YD+W V +A+ M++ GVP R+ + + L
Sbjct: 172 TGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHL 231
Query: 577 SARYEFE 583
+ Y+ E
Sbjct: 232 NGAYKVE 238
>BC126235-1|AAI26236.1| 1144|Homo sapiens adenylate cyclase 3 protein.
Length = 1144
Score = 191 bits (466), Expect = 5e-48
Identities = 110/267 (41%), Positives = 156/267 (58%), Gaps = 20/267 (7%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK-----YS 411
+R E R F + + K+RV MR + L+ N++P HVA + K YS
Sbjct: 857 SRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYS 916
Query: 412 ENHKDVAIIFASIINFNEMYDESYLK--GKEYLRILNELIADFDELLERPQFQHVEKIKT 469
+ + ++ ++FAS+ NF + Y E + G E LR LNE+I+DFD LL+ P+F+ + KIKT
Sbjct: 917 QTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKT 976
Query: 470 IGSTFMAASGLNPDLR-----------HASRGTYDHLYQLMDFALEMQKVVDNFNHDLFE 518
IGST+MAASG+ PD+ + R + HL L DFAL M+ + N N+ F
Sbjct: 977 IGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFN 1036
Query: 519 FDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-S 577
+F+LRIG N G V AGVIG K +YDIWG+ VN+ASRM+STGV IQV E +L
Sbjct: 1037 -NFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILRE 1095
Query: 578 ARYEFEPRGSVYVKGKDDMNVYLLVGK 604
+ F RG ++VKGK ++ + L G+
Sbjct: 1096 YGFRFVRRGPIFVKGKGELLTFFLKGR 1122
Score = 96.7 bits (230), Expect = 2e-19
Identities = 68/246 (27%), Positives = 123/246 (50%), Gaps = 32/246 (13%)
Query: 378 KQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHKD--------------VAIIFAS 423
K ++ Q + L+ +I+P+HVAD++ K E+ KD V+I+FA
Sbjct: 265 KMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFAD 324
Query: 424 IINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPD 483
I+ F ++ S +E +++LNEL A FD+L + H +IK +G + GL PD
Sbjct: 325 IVGFTQL--SSACSAQELVKLLNELFARFDKLAAK---YHQLRIKILGDCYYCICGL-PD 378
Query: 484 LRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLY 543
R DH + L M + + ++ + + +R+G + G V GV+G +
Sbjct: 379 YRE------DHAVCSILMGLAMVEAI-SYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQ 431
Query: 544 YDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP--RGS--VYVKGKDDMNVY 599
YD+W V +A++M++ G+P R+ + ++ + L ++ EP GS Y++ K + Y
Sbjct: 432 YDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEK-GIETY 490
Query: 600 LLVGKK 605
L++ K
Sbjct: 491 LIIASK 496
>AK075424-1|BAC11613.1| 378|Homo sapiens protein ( Homo sapiens
cDNA PSEC0115 fis, clone PLACE1000086, highly similar to
ADENYLATE CYCLASE, OLFACTIVE TYPE (EC 4.6.1.1). ).
Length = 378
Score = 191 bits (466), Expect = 5e-48
Identities = 110/267 (41%), Positives = 156/267 (58%), Gaps = 20/267 (7%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK-----YS 411
+R E R F + + K+RV MR + L+ N++P HVA + K YS
Sbjct: 91 SRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYS 150
Query: 412 ENHKDVAIIFASIINFNEMYDESYLK--GKEYLRILNELIADFDELLERPQFQHVEKIKT 469
+ + ++ ++FAS+ NF + Y E + G E LR LNE+I+DFD LL+ P+F+ + KIKT
Sbjct: 151 QTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKT 210
Query: 470 IGSTFMAASGLNPDLR-----------HASRGTYDHLYQLMDFALEMQKVVDNFNHDLFE 518
IGST+MAASG+ PD+ + R + HL L DFAL M+ + N N+ F
Sbjct: 211 IGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFN 270
Query: 519 FDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-S 577
+F+LRIG N G V AGVIG K +YDIWG+ VN+ASRM+STGV IQV E +L
Sbjct: 271 -NFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILRE 329
Query: 578 ARYEFEPRGSVYVKGKDDMNVYLLVGK 604
+ F RG ++VKGK ++ + L G+
Sbjct: 330 YGFRFVRRGPIFVKGKGELLTFFLKGR 356
>AF033861-1|AAD13403.1| 1144|Homo sapiens type III adenylyl cyclase
protein.
Length = 1144
Score = 191 bits (466), Expect = 5e-48
Identities = 110/267 (41%), Positives = 156/267 (58%), Gaps = 20/267 (7%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK-----YS 411
+R E R F + + K+RV MR + L+ N++P HVA + K YS
Sbjct: 857 SRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYS 916
Query: 412 ENHKDVAIIFASIINFNEMYDESYLK--GKEYLRILNELIADFDELLERPQFQHVEKIKT 469
+ + ++ ++FAS+ NF + Y E + G E LR LNE+I+DFD LL+ P+F+ + KIKT
Sbjct: 917 QTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKT 976
Query: 470 IGSTFMAASGLNPDLR-----------HASRGTYDHLYQLMDFALEMQKVVDNFNHDLFE 518
IGST+MAASG+ PD+ + R + HL L DFAL M+ + N N+ F
Sbjct: 977 IGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFN 1036
Query: 519 FDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-S 577
+F+LRIG N G V AGVIG K +YDIWG+ VN+ASRM+STGV IQV E +L
Sbjct: 1037 -NFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILRE 1095
Query: 578 ARYEFEPRGSVYVKGKDDMNVYLLVGK 604
+ F RG ++VKGK ++ + L G+
Sbjct: 1096 YGFRFVRRGPIFVKGKGELLTFFLKGR 1122
Score = 96.7 bits (230), Expect = 2e-19
Identities = 68/246 (27%), Positives = 123/246 (50%), Gaps = 32/246 (13%)
Query: 378 KQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHKD--------------VAIIFAS 423
K ++ Q + L+ +I+P+HVAD++ K E+ KD V+I+FA
Sbjct: 265 KMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFAD 324
Query: 424 IINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPD 483
I+ F ++ S +E +++LNEL A FD+L + H +IK +G + GL PD
Sbjct: 325 IVGFTQL--SSACSAQELVKLLNELFARFDKLAAK---YHQLRIKILGDCYYCICGL-PD 378
Query: 484 LRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLY 543
R DH + L M + + ++ + + +R+G + G V GV+G +
Sbjct: 379 YRE------DHAVCSILMGLAMVEAI-SYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQ 431
Query: 544 YDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP--RGS--VYVKGKDDMNVY 599
YD+W V +A++M++ G+P R+ + ++ + L ++ EP GS Y++ K + Y
Sbjct: 432 YDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEK-GIETY 490
Query: 600 LLVGKK 605
L++ K
Sbjct: 491 LIIASK 496
>AC012073-2|AAY14787.1| 1144|Homo sapiens unknown protein.
Length = 1144
Score = 191 bits (466), Expect = 5e-48
Identities = 110/267 (41%), Positives = 156/267 (58%), Gaps = 20/267 (7%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK-----YS 411
+R E R F + + K+RV MR + L+ N++P HVA + K YS
Sbjct: 857 SRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYS 916
Query: 412 ENHKDVAIIFASIINFNEMYDESYLK--GKEYLRILNELIADFDELLERPQFQHVEKIKT 469
+ + ++ ++FAS+ NF + Y E + G E LR LNE+I+DFD LL+ P+F+ + KIKT
Sbjct: 917 QTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKT 976
Query: 470 IGSTFMAASGLNPDLR-----------HASRGTYDHLYQLMDFALEMQKVVDNFNHDLFE 518
IGST+MAASG+ PD+ + R + HL L DFAL M+ + N N+ F
Sbjct: 977 IGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFN 1036
Query: 519 FDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-S 577
+F+LRIG N G V AGVIG K +YDIWG+ VN+ASRM+STGV IQV E +L
Sbjct: 1037 -NFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILRE 1095
Query: 578 ARYEFEPRGSVYVKGKDDMNVYLLVGK 604
+ F RG ++VKGK ++ + L G+
Sbjct: 1096 YGFRFVRRGPIFVKGKGELLTFFLKGR 1122
Score = 96.7 bits (230), Expect = 2e-19
Identities = 68/246 (27%), Positives = 123/246 (50%), Gaps = 32/246 (13%)
Query: 378 KQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHKD--------------VAIIFAS 423
K ++ Q + L+ +I+P+HVAD++ K E+ KD V+I+FA
Sbjct: 265 KMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFAD 324
Query: 424 IINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPD 483
I+ F ++ S +E +++LNEL A FD+L + H +IK +G + GL PD
Sbjct: 325 IVGFTQL--SSACSAQELVKLLNELFARFDKLAAK---YHQLRIKILGDCYYCICGL-PD 378
Query: 484 LRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLY 543
R DH + L M + + ++ + + +R+G + G V GV+G +
Sbjct: 379 YRE------DHAVCSILMGLAMVEAI-SYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQ 431
Query: 544 YDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP--RGS--VYVKGKDDMNVY 599
YD+W V +A++M++ G+P R+ + ++ + L ++ EP GS Y++ K + Y
Sbjct: 432 YDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEK-GIETY 490
Query: 600 LLVGKK 605
L++ K
Sbjct: 491 LIIASK 496
>AB011083-1|BAA25437.1| 933|Homo sapiens KIAA0511 protein protein.
Length = 933
Score = 191 bits (466), Expect = 5e-48
Identities = 110/267 (41%), Positives = 156/267 (58%), Gaps = 20/267 (7%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK-----YS 411
+R E R F + + K+RV MR + L+ N++P HVA + K YS
Sbjct: 646 SRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYS 705
Query: 412 ENHKDVAIIFASIINFNEMYDESYLK--GKEYLRILNELIADFDELLERPQFQHVEKIKT 469
+ + ++ ++FAS+ NF + Y E + G E LR LNE+I+DFD LL+ P+F+ + KIKT
Sbjct: 706 QTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKT 765
Query: 470 IGSTFMAASGLNPDLR-----------HASRGTYDHLYQLMDFALEMQKVVDNFNHDLFE 518
IGST+MAASG+ PD+ + R + HL L DFAL M+ + N N+ F
Sbjct: 766 IGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFN 825
Query: 519 FDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-S 577
+F+LRIG N G V AGVIG K +YDIWG+ VN+ASRM+STGV IQV E +L
Sbjct: 826 -NFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILRE 884
Query: 578 ARYEFEPRGSVYVKGKDDMNVYLLVGK 604
+ F RG ++VKGK ++ + L G+
Sbjct: 885 YGFRFVRRGPIFVKGKGELLTFFLKGR 911
Score = 96.7 bits (230), Expect = 2e-19
Identities = 68/246 (27%), Positives = 123/246 (50%), Gaps = 32/246 (13%)
Query: 378 KQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSENHKD--------------VAIIFAS 423
K ++ Q + L+ +I+P+HVAD++ K E+ KD V+I+FA
Sbjct: 54 KMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFAD 113
Query: 424 IINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPD 483
I+ F ++ S +E +++LNEL A FD+L + H +IK +G + GL PD
Sbjct: 114 IVGFTQL--SSACSAQELVKLLNELFARFDKLAAK---YHQLRIKILGDCYYCICGL-PD 167
Query: 484 LRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLY 543
R DH + L M + + ++ + + +R+G + G V GV+G +
Sbjct: 168 YRE------DHAVCSILMGLAMVEAI-SYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQ 220
Query: 544 YDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP--RGS--VYVKGKDDMNVY 599
YD+W V +A++M++ G+P R+ + ++ + L ++ EP GS Y++ K + Y
Sbjct: 221 YDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEK-GIETY 279
Query: 600 LLVGKK 605
L++ K
Sbjct: 280 LIIASK 285
>Z35309-1|CAA84552.1| 1251|Homo sapiens adenylyl cyclase protein.
Length = 1251
Score = 190 bits (464), Expect = 9e-48
Identities = 109/259 (42%), Positives = 154/259 (59%), Gaps = 14/259 (5%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-----KNTAKYSE 412
++ E + RL F V A + ++ +R + +L NI+P HVA N YS+
Sbjct: 917 QQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQ 976
Query: 413 NHKDVAIIFASIINFNEMYDESYL--KGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
++ V ++FASI F + Y ++ + +G E LR+LNE+IADFDELL +FQ +EKIKTI
Sbjct: 977 SYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTI 1036
Query: 471 GSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFG 530
GST+MA SGL+P+ + + HL L DF+L + + + N F +F LRIG + G
Sbjct: 1037 GSTYMAVSGLSPE-KQQCEDKWGHLCALADFSLALTESIQEINKHSFN-NFELRIGISHG 1094
Query: 531 DVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSVY 589
V AGVIG K YDIWG VN+ASRMDSTGV RIQV E +L + + F+ RG +Y
Sbjct: 1095 SVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIY 1154
Query: 590 VKG----KDDMNVYLLVGK 604
VKG + + Y L+G+
Sbjct: 1155 VKGISEQEGKIKTYFLLGR 1173
Score = 91.9 bits (218), Expect = 6e-18
Identities = 58/190 (30%), Positives = 96/190 (50%), Gaps = 15/190 (7%)
Query: 394 NIIPRHVADQLKNTAKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFD 453
N+ H+ Q Y +++V+I+FA + F + + L +E +R+LNEL A FD
Sbjct: 392 NVEDEHLQHQFHRI--YIHRYENVSILFADVKGFTNL--STTLSAQELVRMLNELFARFD 447
Query: 454 ELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFN 513
L H +IK +G + SGL P+ R DH + ++ L M K + +
Sbjct: 448 RLAHE---HHCLRIKILGDCYYCVSGL-PEPRQ------DHAHCCVEMGLSMIKTI-RYV 496
Query: 514 HDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACV 573
+ D +RIG + G V GV+G K +D+W V+IA++++S G+P RI + +A +
Sbjct: 497 RSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATL 556
Query: 574 PVLSARYEFE 583
L+ Y E
Sbjct: 557 DCLNGDYNVE 566
>M83533-1|AAA35523.2| 675|Homo sapiens adenylyl cyclase type V
protein.
Length = 675
Score = 190 bits (464), Expect = 9e-48
Identities = 109/259 (42%), Positives = 154/259 (59%), Gaps = 14/259 (5%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-----KNTAKYSE 412
++ E + RL F V A + ++ +R + +L NI+P HVA N YS+
Sbjct: 341 QQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQ 400
Query: 413 NHKDVAIIFASIINFNEMYDESYL--KGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
++ V ++FASI F + Y ++ + +G E LR+LNE+IADFDELL +FQ +EKIKTI
Sbjct: 401 SYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTI 460
Query: 471 GSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFG 530
GST+MA SGL+P+ + + HL L DF+L + + + N F +F LRIG + G
Sbjct: 461 GSTYMAVSGLSPE-KQQCEDKWGHLCALADFSLALTESIQEINKHSFN-NFELRIGISHG 518
Query: 531 DVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSVY 589
V AGVIG K YDIWG VN+ASRMDSTGV RIQV E +L + + F+ RG +Y
Sbjct: 519 SVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIY 578
Query: 590 VKG----KDDMNVYLLVGK 604
VKG + + Y L+G+
Sbjct: 579 VKGISEQEGKIKTYFLLGR 597
>BC117475-1|AAI17476.1| 1077|Homo sapiens adenylate cyclase 4 protein.
Length = 1077
Score = 190 bits (462), Expect = 2e-47
Identities = 110/256 (42%), Positives = 152/256 (59%), Gaps = 13/256 (5%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-----KNTAKYSE 412
R+ E RL F ++++ + M N LL N++P HVA Q +N Y +
Sbjct: 808 RQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQ 867
Query: 413 NHKDVAIIFASIINFNEMYDESYL--KGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
+++ V ++FAS+ +F E Y ES + +G E LR+LNE+IADFDELL +P+F VEKIKTI
Sbjct: 868 SYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTI 927
Query: 471 GSTFMAASGLN----PDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIG 526
GST+MAA+GLN D + + + HL +++FA+ + +D N F +F LR+G
Sbjct: 928 GSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFN-NFRLRVG 986
Query: 527 YNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-SARYEFEPR 585
N G V AGVIG K YDIWG+ VN+ASRM+STGV +IQV E L S Y R
Sbjct: 987 LNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGYTCYSR 1046
Query: 586 GSVYVKGKDDMNVYLL 601
G + VKGK + Y L
Sbjct: 1047 GVIKVKGKGQLCTYFL 1062
Score = 84.2 bits (199), Expect = 1e-15
Identities = 51/177 (28%), Positives = 85/177 (48%), Gaps = 13/177 (7%)
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
Y + H+ V++++A I+ F + E KE + +LNEL FD++ + + +IK
Sbjct: 265 YVKRHQGVSVLYADIVGFTRLASEC--SPKELVLMLNELFGKFDQIAKEHECM---RIKI 319
Query: 470 IGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
+G + SGL L DH + L+M + + D +R+G +
Sbjct: 320 LGDCYYCVSGLPLSLP-------DHAINCVRMGLDMCRAIRKLRAAT-GVDINMRVGVHS 371
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRG 586
G V GVIG K YD+W V +A+ M++ GVP R+ + A + +L+ Y E G
Sbjct: 372 GSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVEDAG 428
>BC117473-1|AAI17474.1| 1077|Homo sapiens adenylate cyclase 4 protein.
Length = 1077
Score = 190 bits (462), Expect = 2e-47
Identities = 110/256 (42%), Positives = 152/256 (59%), Gaps = 13/256 (5%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-----KNTAKYSE 412
R+ E RL F ++++ + M N LL N++P HVA Q +N Y +
Sbjct: 808 RQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQ 867
Query: 413 NHKDVAIIFASIINFNEMYDESYL--KGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
+++ V ++FAS+ +F E Y ES + +G E LR+LNE+IADFDELL +P+F VEKIKTI
Sbjct: 868 SYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTI 927
Query: 471 GSTFMAASGLN----PDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIG 526
GST+MAA+GLN D + + + HL +++FA+ + +D N F +F LR+G
Sbjct: 928 GSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFN-NFRLRVG 986
Query: 527 YNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-SARYEFEPR 585
N G V AGVIG K YDIWG+ VN+ASRM+STGV +IQV E L S Y R
Sbjct: 987 LNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGYTCYSR 1046
Query: 586 GSVYVKGKDDMNVYLL 601
G + VKGK + Y L
Sbjct: 1047 GVIKVKGKGQLCTYFL 1062
Score = 84.2 bits (199), Expect = 1e-15
Identities = 51/177 (28%), Positives = 85/177 (48%), Gaps = 13/177 (7%)
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
Y + H+ V++++A I+ F + E KE + +LNEL FD++ + + +IK
Sbjct: 265 YVKRHQGVSVLYADIVGFTRLASEC--SPKELVLMLNELFGKFDQIAKEHECM---RIKI 319
Query: 470 IGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
+G + SGL L DH + L+M + + D +R+G +
Sbjct: 320 LGDCYYCVSGLPLSLP-------DHAINCVRMGLDMCRAIRKLRAAT-GVDINMRVGVHS 371
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRG 586
G V GVIG K YD+W V +A+ M++ GVP R+ + A + +L+ Y E G
Sbjct: 372 GSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVEDAG 428
>AK056745-1|BAB71270.1| 506|Homo sapiens protein ( Homo sapiens
cDNA FLJ32183 fis, clone PLACE6001886, highly similar to
ADENYLATE CYCLASE, TYPE IV (EC 4.6.1.1). ).
Length = 506
Score = 190 bits (462), Expect = 2e-47
Identities = 110/256 (42%), Positives = 152/256 (59%), Gaps = 13/256 (5%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-----KNTAKYSE 412
R+ E RL F ++++ + M N LL N++P HVA Q +N Y +
Sbjct: 237 RQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQ 296
Query: 413 NHKDVAIIFASIINFNEMYDESYL--KGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
+++ V ++FAS+ +F E Y ES + +G E LR+LNE+IADFDELL +P+F VEKIKTI
Sbjct: 297 SYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTI 356
Query: 471 GSTFMAASGLN----PDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIG 526
GST+MAA+GLN D + + + HL +++FA+ + +D N F +F LR+G
Sbjct: 357 GSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFN-NFRLRVG 415
Query: 527 YNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-SARYEFEPR 585
N G V AGVIG K YDIWG+ VN+ASRM+STGV +IQV E L S Y R
Sbjct: 416 LNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGYTCYSR 475
Query: 586 GSVYVKGKDDMNVYLL 601
G + VKGK + Y L
Sbjct: 476 GVIKVKGKGQLCTYFL 491
>AF497516-1|AAM94373.1| 1077|Homo sapiens adenylate cyclase type IV
protein.
Length = 1077
Score = 190 bits (462), Expect = 2e-47
Identities = 110/256 (42%), Positives = 152/256 (59%), Gaps = 13/256 (5%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-----KNTAKYSE 412
R+ E RL F ++++ + M N LL N++P HVA Q +N Y +
Sbjct: 808 RQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQ 867
Query: 413 NHKDVAIIFASIINFNEMYDESYL--KGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
+++ V ++FAS+ +F E Y ES + +G E LR+LNE+IADFDELL +P+F VEKIKTI
Sbjct: 868 SYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTI 927
Query: 471 GSTFMAASGLN----PDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIG 526
GST+MAA+GLN D + + + HL +++FA+ + +D N F +F LR+G
Sbjct: 928 GSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFN-NFRLRVG 986
Query: 527 YNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL-SARYEFEPR 585
N G V AGVIG K YDIWG+ VN+ASRM+STGV +IQV E L S Y R
Sbjct: 987 LNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGYTCYSR 1046
Query: 586 GSVYVKGKDDMNVYLL 601
G + VKGK + Y L
Sbjct: 1047 GVIKVKGKGQLCTYFL 1062
Score = 84.2 bits (199), Expect = 1e-15
Identities = 51/177 (28%), Positives = 85/177 (48%), Gaps = 13/177 (7%)
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
Y + H+ V++++A I+ F + E KE + +LNEL FD++ + + +IK
Sbjct: 265 YVKRHQGVSVLYADIVGFTRLASEC--SPKELVLMLNELFGKFDQIAKEHECM---RIKI 319
Query: 470 IGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
+G + SGL L DH + L+M + + D +R+G +
Sbjct: 320 LGDCYYCVSGLPLSLP-------DHAINCVRMGLDMCRAIRKLRAAT-GVDINMRVGVHS 371
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEPRG 586
G V GVIG K YD+W V +A+ M++ GVP R+ + A + +L+ Y E G
Sbjct: 372 GSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVEDAG 428
>DQ104739-1|AAZ13596.1| 1120|Homo sapiens brain adenylate cyclase 8
protein.
Length = 1120
Score = 188 bits (457), Expect = 7e-47
Identities = 108/259 (41%), Positives = 153/259 (59%), Gaps = 14/259 (5%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-----KNTAKYSE 412
++ E + RL F V A + ++ +R + +L NI+P HVA N YS+
Sbjct: 786 QQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDQDNEELYSQ 845
Query: 413 NHKDVAIIFASIINFNEMYDESYL--KGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
++ V ++FASI F + Y ++ + +G E LR+LNE+IADFDELL +FQ +EKIKTI
Sbjct: 846 SYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTI 905
Query: 471 GSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFG 530
GST+MA SG +P+ + + HL L DF+L + + + N F +F LRIG + G
Sbjct: 906 GSTYMAVSGPSPE-KQQCEDKWGHLCALADFSLALTESIQEINKHSFN-NFELRIGISHG 963
Query: 531 DVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR-YEFEPRGSVY 589
V AGVIG K YDIWG VN+ASRMDSTGV RIQV E +L + + F+ RG +Y
Sbjct: 964 SVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIY 1023
Query: 590 VKG----KDDMNVYLLVGK 604
VKG + + Y L+G+
Sbjct: 1024 VKGISEQEGKIKTYFLLGR 1042
Score = 94.7 bits (225), Expect = 8e-19
Identities = 61/201 (30%), Positives = 103/201 (51%), Gaps = 16/201 (7%)
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
Y +++V+I+FA + F + + L +E +R+LNEL A FD L+ H +IK
Sbjct: 406 YIHRYENVSILFADVKGFTNL--SATLSAQELVRMLNELFARFDRLVHE---HHCLRIKI 460
Query: 470 IGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
+G + SGL P+ R DH + ++ L M K + + + D +RIG +
Sbjct: 461 LGDCYYCVSGL-PEPRQ------DHAHCCVEMGLSMIKTI-RYVRSRTKHDVDMRIGIHS 512
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP---RG 586
G V GV+G K +D+W V+IA++++S G+P RI + EA + L+ Y E +
Sbjct: 513 GSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISEATLDCLNGDYNVEEGHGKE 572
Query: 587 SVYVKGKDDMNVYLLVGKKDT 607
GK ++ YL+ +D+
Sbjct: 573 RNEFLGKHNIETYLIKQPEDS 593
>AB209496-1|BAD92733.1| 1045|Homo sapiens brain adenylate cyclase 1
variant protein.
Length = 1045
Score = 182 bits (443), Expect = 3e-45
Identities = 99/221 (44%), Positives = 137/221 (61%), Gaps = 9/221 (4%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQL-----KNTAKYSE 412
R+ +I RL + A +++ ++ ++ +L N++P HVA +N Y +
Sbjct: 790 RQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQ 849
Query: 413 NHKDVAIIFASIINFNEMYDE--SYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
++ V ++FASI NFN+ Y E G E LR+LNE+IADFDEL+E+ ++ +EKIKTI
Sbjct: 850 SYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTI 909
Query: 471 GSTFMAASGLNPDL-RHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
GST+MAA GL P A + HL L DFA+EM V+D N+ + DF+LR+G N
Sbjct: 910 GSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFDVLDEINYQSYN-DFVLRVGINV 968
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGE 570
G V AGVIG + YDIWG+ VN+ASRMDSTGV RIQV E
Sbjct: 969 GPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTE 1009
Score = 101 bits (242), Expect = 7e-21
Identities = 65/234 (27%), Positives = 117/234 (50%), Gaps = 23/234 (9%)
Query: 361 EISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAK----------Y 410
E S R +F D+ R+++ + + LL +++PR+VA ++K Y
Sbjct: 223 ERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIY 282
Query: 411 SENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTI 470
+ H +V+I+FA I+ F + S +E +++LNEL FDEL H +IK +
Sbjct: 283 IQRHDNVSILFADIVGFTGL--ASQCTAQELVKLLNELFGKFDELATE---NHCRRIKIL 337
Query: 471 GSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFG 530
G + SGL ++ DH + ++ L+M + + + E D +R+G + G
Sbjct: 338 GDCYYCVSGL-------TQPKTDHAHCCVEMGLDMIDTITSVA-EATEVDLNMRVGLHTG 389
Query: 531 DVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFEP 584
V GV+G K YD+W + V +A+ M++ G+P ++ + + + L+ YE EP
Sbjct: 390 RVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEP 443
>D25538-1|BAA05021.2| 1088|Homo sapiens KIAA0037 protein.
Length = 1088
Score = 172 bits (419), Expect = 3e-42
Identities = 102/256 (39%), Positives = 149/256 (58%), Gaps = 13/256 (5%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVA-----DQLKNTAKYS 411
+R+ + RL ++ + + M N LL N++P HVA D+L N Y
Sbjct: 822 SRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKL-NEDWYH 880
Query: 412 ENHKDVAIIFASIINFNEMYDESYL--KGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
+++ V ++FAS+ +F Y E + +G E LR+LNE+IADFDELL +P+F VEKIKT
Sbjct: 881 QSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKT 940
Query: 470 IGSTFMAASGLNPDLRHASR---GTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIG 526
IGST+MAA+GL+ H ++ + H+ +++F++ + +D N F F LR+G
Sbjct: 941 IGSTYMAAAGLSVASGHENQELERQHAHIGVMVEFSIALMSKLDGINRHSFN-SFRLRVG 999
Query: 527 YNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQV-GEACVPVLSARYEFEPR 585
N G V AGVIG K YDIWG+ VN+ASRM+STG +IQV E C + Y E R
Sbjct: 1000 INHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECR 1059
Query: 586 GSVYVKGKDDMNVYLL 601
G + VKGK ++ Y +
Sbjct: 1060 GLINVKGKGELRTYFV 1075
Score = 88.6 bits (210), Expect = 6e-17
Identities = 52/174 (29%), Positives = 89/174 (51%), Gaps = 13/174 (7%)
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
Y + H++V+I++A I+ F ++ + KE + +LNEL FD++ + + +IK
Sbjct: 279 YVKRHQNVSILYADIVGFTQLASDC--SPKELVVVLNELFGKFDQIAKANECM---RIKI 333
Query: 470 IGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
+G + SGL L H + L+M + + + D +R+G +
Sbjct: 334 LGDCYYCVSGLPVSLP-------THARNCVKMGLDMCQAIKQVR-EATGVDINMRVGIHS 385
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFE 583
G+V GVIG K YD+W V++A+RM++ GVP R+ + EA + L YE E
Sbjct: 386 GNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLKHLDKAYEVE 439
>BC126271-1|AAI26272.1| 1080|Homo sapiens adenylate cyclase 7 protein.
Length = 1080
Score = 172 bits (419), Expect = 3e-42
Identities = 102/256 (39%), Positives = 149/256 (58%), Gaps = 13/256 (5%)
Query: 357 NREFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVA-----DQLKNTAKYS 411
+R+ + RL ++ + + M N LL N++P HVA D+L N Y
Sbjct: 814 SRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKL-NEDWYH 872
Query: 412 ENHKDVAIIFASIINFNEMYDESYL--KGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
+++ V ++FAS+ +F Y E + +G E LR+LNE+IADFDELL +P+F VEKIKT
Sbjct: 873 QSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKT 932
Query: 470 IGSTFMAASGLNPDLRHASR---GTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIG 526
IGST+MAA+GL+ H ++ + H+ +++F++ + +D N F F LR+G
Sbjct: 933 IGSTYMAAAGLSVASGHENQELERQHAHIGVMVEFSIALMSKLDGINRHSFN-SFRLRVG 991
Query: 527 YNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQV-GEACVPVLSARYEFEPR 585
N G V AGVIG K YDIWG+ VN+ASRM+STG +IQV E C + Y E R
Sbjct: 992 INHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECR 1051
Query: 586 GSVYVKGKDDMNVYLL 601
G + VKGK ++ Y +
Sbjct: 1052 GLINVKGKGELRTYFV 1067
Score = 88.6 bits (210), Expect = 6e-17
Identities = 52/174 (29%), Positives = 89/174 (51%), Gaps = 13/174 (7%)
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
Y + H++V+I++A I+ F ++ + KE + +LNEL FD++ + + +IK
Sbjct: 271 YVKRHQNVSILYADIVGFTQLASDC--SPKELVVVLNELFGKFDQIAKANECM---RIKI 325
Query: 470 IGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
+G + SGL L H + L+M + + + D +R+G +
Sbjct: 326 LGDCYYCVSGLPVSLP-------THARNCVKMGLDMCQAIKQVR-EATGVDINMRVGIHS 377
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEFE 583
G+V GVIG K YD+W V++A+RM++ GVP R+ + EA + L YE E
Sbjct: 378 GNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLKHLDKAYEVE 431
>S57551-1|AAB19934.2| 1073|Homo sapiens guanylate cyclase-coupled
enterotoxin receptor protein.
Length = 1073
Score = 113 bits (271), Expect = 2e-24
Identities = 81/250 (32%), Positives = 127/250 (50%), Gaps = 19/250 (7%)
Query: 365 RLSFYSNVVANRDKQRVQNM---RNQADWLLHNIIPRHVADQLKNTAKYS-ENHKDVAII 420
RL YS + + ++R Q R++AD L ++PR V LK E +++V I
Sbjct: 767 RLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIY 826
Query: 421 FASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL 480
F+ I+ F + Y E + +LN++ FD +++ V K++TIG +M ASGL
Sbjct: 827 FSDIVGFTTIC--KYSTPMEVVDMLNDIYKSFDHIVDH---HDVYKVETIGDAYMVASGL 881
Query: 481 NPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHD-LFEFDFILRIGYNFGDVTAGVIGT 539
R+ +R H + ALE+ + F + L +RIG + G AGV+G
Sbjct: 882 PK--RNGNR----HAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGI 935
Query: 540 TKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL---SARYEFEPRGSVYVKGKDDM 596
Y ++GD VN ASRM+STG+P RI V + + +L ++ +E RG Y+KG+ +
Sbjct: 936 KMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNE 995
Query: 597 NVYLLVGKKD 606
Y L G KD
Sbjct: 996 TTYWLTGMKD 1005
>M73489-1|AAA36655.1| 1073|Homo sapiens heat-stable enterotoxin
receptor protein.
Length = 1073
Score = 113 bits (271), Expect = 2e-24
Identities = 81/250 (32%), Positives = 127/250 (50%), Gaps = 19/250 (7%)
Query: 365 RLSFYSNVVANRDKQRVQNM---RNQADWLLHNIIPRHVADQLKNTAKYS-ENHKDVAII 420
RL YS + + ++R Q R++AD L ++PR V LK E +++V I
Sbjct: 767 RLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIY 826
Query: 421 FASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL 480
F+ I+ F + Y E + +LN++ FD +++ V K++TIG +M ASGL
Sbjct: 827 FSDIVGFTTIC--KYSTPMEVVDMLNDIYKSFDHIVDH---HDVYKVETIGDAYMVASGL 881
Query: 481 NPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHD-LFEFDFILRIGYNFGDVTAGVIGT 539
R+ +R H + ALE+ + F + L +RIG + G AGV+G
Sbjct: 882 PK--RNGNR----HAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGI 935
Query: 540 TKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL---SARYEFEPRGSVYVKGKDDM 596
Y ++GD VN ASRM+STG+P RI V + + +L ++ +E RG Y+KG+ +
Sbjct: 936 KMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNE 995
Query: 597 NVYLLVGKKD 606
Y L G KD
Sbjct: 996 TTYWLTGMKD 1005
>L37378-1|AAA74451.1| 1108|Homo sapiens guanylyl cyclase protein.
Length = 1108
Score = 109 bits (261), Expect = 4e-23
Identities = 82/248 (33%), Positives = 128/248 (51%), Gaps = 19/248 (7%)
Query: 366 LSFYSNVVANRDKQRVQNM---RNQADWLLHNIIPRHVADQLKNTAKYSENHKD-VAIIF 421
L YS+ + + ++R + + + + + LL ++P VA+ LK D V + F
Sbjct: 828 LEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYF 887
Query: 422 ASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLN 481
+ I+ F + S + E + +LN+L FD ++ V K++TIG +M ASGL
Sbjct: 888 SDIVGFTTISAMS--EPIEVVDLLNDLYTLFDAIIGS---HDVYKVETIGDAYMVASGLP 942
Query: 482 PDLRHASRGTYDHLYQLMDFALEMQKVVDNFN-HDLFEFDFILRIGYNFGDVTAGVIGTT 540
R+ SR H ++ + +L++ V F + E +RIG + G V AGV+G T
Sbjct: 943 K--RNGSR----HAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLT 996
Query: 541 KLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPV---LSARYEFEPRGSVYVKGKDDMN 597
Y ++GD VN ASRM+STG+P RI V + V + LS YE E RG +KGK
Sbjct: 997 MPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEE 1056
Query: 598 VYLLVGKK 605
+ L+GKK
Sbjct: 1057 TFWLIGKK 1064
>AL031387-4|CAB41303.1| 1108|Homo sapiens guanylate cyclase 2F,
retinal protein.
Length = 1108
Score = 109 bits (261), Expect = 4e-23
Identities = 82/248 (33%), Positives = 128/248 (51%), Gaps = 19/248 (7%)
Query: 366 LSFYSNVVANRDKQRVQNM---RNQADWLLHNIIPRHVADQLKNTAKYSENHKD-VAIIF 421
L YS+ + + ++R + + + + + LL ++P VA+ LK D V + F
Sbjct: 828 LEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYF 887
Query: 422 ASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLN 481
+ I+ F + S + E + +LN+L FD ++ V K++TIG +M ASGL
Sbjct: 888 SDIVGFTTISAMS--EPIEVVDLLNDLYTLFDAIIGS---HDVYKVETIGDAYMVASGLP 942
Query: 482 PDLRHASRGTYDHLYQLMDFALEMQKVVDNFN-HDLFEFDFILRIGYNFGDVTAGVIGTT 540
R+ SR H ++ + +L++ V F + E +RIG + G V AGV+G T
Sbjct: 943 K--RNGSR----HAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLT 996
Query: 541 KLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPV---LSARYEFEPRGSVYVKGKDDMN 597
Y ++GD VN ASRM+STG+P RI V + V + LS YE E RG +KGK
Sbjct: 997 MPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEE 1056
Query: 598 VYLLVGKK 605
+ L+GKK
Sbjct: 1057 TFWLIGKK 1064
>M92432-1|AAA60547.1| 1103|Homo sapiens guanylyl cyclase protein.
Length = 1103
Score = 106 bits (255), Expect = 2e-22
Identities = 81/248 (32%), Positives = 130/248 (52%), Gaps = 19/248 (7%)
Query: 366 LSFYSNVVANRDKQRVQNM---RNQADWLLHNIIPRHVADQLKN-TAKYSENHKDVAIIF 421
L YS+ + + ++R + + + + D LL ++P VA+ LK T E + V + F
Sbjct: 824 LEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYF 883
Query: 422 ASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLN 481
+ I+ F + S + E + +LN+L FD ++ V K++TIG +M ASGL
Sbjct: 884 SDIVGFTTISAMS--EPIEVVDLLNDLYTLFDAIIGS---HDVYKVETIGDAYMVASGL- 937
Query: 482 PDLRHASRGTYDHLYQLMDFALEMQKVVDNFN-HDLFEFDFILRIGYNFGDVTAGVIGTT 540
P R+ R H ++ + +L++ V F + E +RIG + G AGV+G T
Sbjct: 938 PQ-RNGQR----HAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLT 992
Query: 541 KLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSA---RYEFEPRGSVYVKGKDDMN 597
Y ++GD VN ASRM+STG+P RI V + V +L A Y+ E RG +KGK +
Sbjct: 993 MPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAED 1052
Query: 598 VYLLVGKK 605
+ LVG++
Sbjct: 1053 TFWLVGRR 1060
>AJ222657-1|CAA10914.1| 1103|Homo sapiens guanylyl cyclase protein.
Length = 1103
Score = 106 bits (255), Expect = 2e-22
Identities = 81/248 (32%), Positives = 130/248 (52%), Gaps = 19/248 (7%)
Query: 366 LSFYSNVVANRDKQRVQNM---RNQADWLLHNIIPRHVADQLKN-TAKYSENHKDVAIIF 421
L YS+ + + ++R + + + + D LL ++P VA+ LK T E + V + F
Sbjct: 824 LEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYF 883
Query: 422 ASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLN 481
+ I+ F + S + E + +LN+L FD ++ V K++TIG +M ASGL
Sbjct: 884 SDIVGFTTISAMS--EPIEVVDLLNDLYTLFDAIIGS---HDVYKVETIGDAYMVASGL- 937
Query: 482 PDLRHASRGTYDHLYQLMDFALEMQKVVDNFN-HDLFEFDFILRIGYNFGDVTAGVIGTT 540
P R+ R H ++ + +L++ V F + E +RIG + G AGV+G T
Sbjct: 938 PQ-RNGQR----HAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLT 992
Query: 541 KLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSA---RYEFEPRGSVYVKGKDDMN 597
Y ++GD VN ASRM+STG+P RI V + V +L A Y+ E RG +KGK +
Sbjct: 993 MPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAED 1052
Query: 598 VYLLVGKK 605
+ LVG++
Sbjct: 1053 TFWLVGRR 1060
>BC023017-1|AAH23017.1| 618|Homo sapiens NPR2 protein protein.
Length = 618
Score = 104 bits (250), Expect = 8e-22
Identities = 80/248 (32%), Positives = 122/248 (49%), Gaps = 18/248 (7%)
Query: 365 RLSFYSNVVANRDKQRVQ---NMRNQADWLLHNIIPRHVADQLKN-TAKYSENHKDVAII 420
R+ Y+N + ++R Q + +A+ LL+ I+P VA+QLK +E V I
Sbjct: 375 RMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIY 434
Query: 421 FASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL 480
F+ I+ F + ES + + +LN+L FD +++ F V K++TIG +M SGL
Sbjct: 435 FSDIVGFTALSAES--TPMQVVTLLNDLYTCFDAIIDN--FD-VYKVETIGDAYMVVSGL 489
Query: 481 NPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFI-LRIGYNFGDVTAGVIGT 539
R H ++ AL + V +F D + LRIG + G V AGV+G
Sbjct: 490 ------PGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGL 543
Query: 540 TKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDMN 597
Y ++GD VN ASRM+S G +I V L ++ E RG V +KGK M
Sbjct: 544 KMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMR 603
Query: 598 VYLLVGKK 605
Y L+G++
Sbjct: 604 TYWLLGER 611
>AL133410-13|CAI10987.1| 1047|Homo sapiens natriuretic peptide
receptor B/guanylate cyclase B (atrionatriuretic peptide
re protein.
Length = 1047
Score = 104 bits (250), Expect = 8e-22
Identities = 80/248 (32%), Positives = 122/248 (49%), Gaps = 18/248 (7%)
Query: 365 RLSFYSNVVANRDKQRVQ---NMRNQADWLLHNIIPRHVADQLKN-TAKYSENHKDVAII 420
R+ Y+N + ++R Q + +A+ LL+ I+P VA+QLK +E V I
Sbjct: 804 RMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIY 863
Query: 421 FASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL 480
F+ I+ F + ES + + +LN+L FD +++ F V K++TIG +M SGL
Sbjct: 864 FSDIVGFTALSAES--TPMQVVTLLNDLYTCFDAIIDN--FD-VYKVETIGDAYMVVSGL 918
Query: 481 NPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFI-LRIGYNFGDVTAGVIGT 539
R H ++ AL + V +F D + LRIG + G V AGV+G
Sbjct: 919 ------PGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGL 972
Query: 540 TKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDMN 597
Y ++GD VN ASRM+S G +I V L ++ E RG V +KGK M
Sbjct: 973 KMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMR 1032
Query: 598 VYLLVGKK 605
Y L+G++
Sbjct: 1033 TYWLLGER 1040
>AB005647-1|BAA81737.1| 1047|Homo sapiens atrial natriuretic peptide
Btype receptor protein.
Length = 1047
Score = 104 bits (250), Expect = 8e-22
Identities = 80/248 (32%), Positives = 122/248 (49%), Gaps = 18/248 (7%)
Query: 365 RLSFYSNVVANRDKQRVQ---NMRNQADWLLHNIIPRHVADQLKN-TAKYSENHKDVAII 420
R+ Y+N + ++R Q + +A+ LL+ I+P VA+QLK +E V I
Sbjct: 804 RMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIY 863
Query: 421 FASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL 480
F+ I+ F + ES + + +LN+L FD +++ F V K++TIG +M SGL
Sbjct: 864 FSDIVGFTALSAES--TPMQVVTLLNDLYTCFDAIIDN--FD-VYKVETIGDAYMVVSGL 918
Query: 481 NPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFI-LRIGYNFGDVTAGVIGT 539
R H ++ AL + V +F D + LRIG + G V AGV+G
Sbjct: 919 ------PGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGL 972
Query: 540 TKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDMN 597
Y ++GD VN ASRM+S G +I V L ++ E RG V +KGK M
Sbjct: 973 KMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMR 1032
Query: 598 VYLLVGKK 605
Y L+G++
Sbjct: 1033 TYWLLGER 1040
>X15357-1|CAA33417.1| 1061|Homo sapiens ANP-A receptor preprotein (AA
-32 to 1029) protein.
Length = 1061
Score = 100 bits (239), Expect = 2e-20
Identities = 81/249 (32%), Positives = 123/249 (49%), Gaps = 20/249 (8%)
Query: 365 RLSFYSNVVANRDKQRVQ---NMRNQADWLLHNIIPRHVADQLKN-TAKYSENHKDVAII 420
R+ Y+N + ++R Q + +A+ LL+ I+P VA+QLK +E V I
Sbjct: 819 RMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIY 878
Query: 421 FASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL 480
F+ I+ F + ES + + +LN+L FD +++ F V K++TIG +M SGL
Sbjct: 879 FSDIVGFTALSAES--TPMQVVTLLNDLYTCFDAVIDN--FD-VYKVETIGDAYMVVSGL 933
Query: 481 NPDLRHASRGTYDHLYQLMDFALEMQKVVDNFN--HDLFEFDFILRIGYNFGDVTAGVIG 538
R H ++ AL + V +F H E LRIG + G V AGV+G
Sbjct: 934 ------PVRNGRLHACEVARMALALLDAVRSFRIRHRPQE-QLRLRIGIHTGPVCAGVVG 986
Query: 539 TTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDM 596
Y ++GD VN ASRM+S G +I + VL +E E RG V +KGK +
Sbjct: 987 LKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKV 1046
Query: 597 NVYLLVGKK 605
Y L+G++
Sbjct: 1047 RTYWLLGER 1055
>BC063304-1|AAH63304.1| 1061|Homo sapiens natriuretic peptide receptor
A/guanylate cyclase A (atrionatriuretic peptide re
protein.
Length = 1061
Score = 100 bits (239), Expect = 2e-20
Identities = 81/249 (32%), Positives = 123/249 (49%), Gaps = 20/249 (8%)
Query: 365 RLSFYSNVVANRDKQRVQ---NMRNQADWLLHNIIPRHVADQLKN-TAKYSENHKDVAII 420
R+ Y+N + ++R Q + +A+ LL+ I+P VA+QLK +E V I
Sbjct: 819 RMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIY 878
Query: 421 FASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL 480
F+ I+ F + ES + + +LN+L FD +++ F V K++TIG +M SGL
Sbjct: 879 FSDIVGFTALSAES--TPMQVVTLLNDLYTCFDAVIDN--FD-VYKVETIGDAYMVVSGL 933
Query: 481 NPDLRHASRGTYDHLYQLMDFALEMQKVVDNFN--HDLFEFDFILRIGYNFGDVTAGVIG 538
R H ++ AL + V +F H E LRIG + G V AGV+G
Sbjct: 934 ------PVRNGRLHACEVARMALALLDAVRSFRIRHRPQE-QLRLRIGIHTGPVCAGVVG 986
Query: 539 TTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDM 596
Y ++GD VN ASRM+S G +I + VL +E E RG V +KGK +
Sbjct: 987 LKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKV 1046
Query: 597 NVYLLVGKK 605
Y L+G++
Sbjct: 1047 RTYWLLGER 1055
>AL713889-4|CAI13613.1| 1061|Homo sapiens natriuretic peptide receptor
A/guanylate cyclase A (atrionatriuretic peptide re
protein.
Length = 1061
Score = 100 bits (239), Expect = 2e-20
Identities = 81/249 (32%), Positives = 123/249 (49%), Gaps = 20/249 (8%)
Query: 365 RLSFYSNVVANRDKQRVQ---NMRNQADWLLHNIIPRHVADQLKN-TAKYSENHKDVAII 420
R+ Y+N + ++R Q + +A+ LL+ I+P VA+QLK +E V I
Sbjct: 819 RMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIY 878
Query: 421 FASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL 480
F+ I+ F + ES + + +LN+L FD +++ F V K++TIG +M SGL
Sbjct: 879 FSDIVGFTALSAES--TPMQVVTLLNDLYTCFDAVIDN--FD-VYKVETIGDAYMVVSGL 933
Query: 481 NPDLRHASRGTYDHLYQLMDFALEMQKVVDNFN--HDLFEFDFILRIGYNFGDVTAGVIG 538
R H ++ AL + V +F H E LRIG + G V AGV+G
Sbjct: 934 ------PVRNGRLHACEVARMALALLDAVRSFRIRHRPQE-QLRLRIGIHTGPVCAGVVG 986
Query: 539 TTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDM 596
Y ++GD VN ASRM+S G +I + VL +E E RG V +KGK +
Sbjct: 987 LKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKV 1046
Query: 597 NVYLLVGKK 605
Y L+G++
Sbjct: 1047 RTYWLLGER 1055
>AF190631-1|AAF01340.1| 1061|Homo sapiens natriuretic peptide receptor
A protein.
Length = 1061
Score = 100 bits (239), Expect = 2e-20
Identities = 81/249 (32%), Positives = 123/249 (49%), Gaps = 20/249 (8%)
Query: 365 RLSFYSNVVANRDKQRVQ---NMRNQADWLLHNIIPRHVADQLKN-TAKYSENHKDVAII 420
R+ Y+N + ++R Q + +A+ LL+ I+P VA+QLK +E V I
Sbjct: 819 RMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIY 878
Query: 421 FASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL 480
F+ I+ F + ES + + +LN+L FD +++ F V K++TIG +M SGL
Sbjct: 879 FSDIVGFTALSAES--TPMQVVTLLNDLYTCFDAVIDN--FD-VYKVETIGDAYMVVSGL 933
Query: 481 NPDLRHASRGTYDHLYQLMDFALEMQKVVDNFN--HDLFEFDFILRIGYNFGDVTAGVIG 538
R H ++ AL + V +F H E LRIG + G V AGV+G
Sbjct: 934 ------PVRNGRLHACEVARMALALLDAVRSFRIRHRPQE-QLRLRIGIHTGPVCAGVVG 986
Query: 539 TTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDM 596
Y ++GD VN ASRM+S G +I + VL +E E RG V +KGK +
Sbjct: 987 LKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKV 1046
Query: 597 NVYLLVGKK 605
Y L+G++
Sbjct: 1047 RTYWLLGER 1055
>AB010491-1|BAA31199.1| 1061|Homo sapiens natriuretic peptide A type
receptor protein.
Length = 1061
Score = 100 bits (239), Expect = 2e-20
Identities = 81/249 (32%), Positives = 123/249 (49%), Gaps = 20/249 (8%)
Query: 365 RLSFYSNVVANRDKQRVQ---NMRNQADWLLHNIIPRHVADQLKN-TAKYSENHKDVAII 420
R+ Y+N + ++R Q + +A+ LL+ I+P VA+QLK +E V I
Sbjct: 819 RMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIY 878
Query: 421 FASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL 480
F+ I+ F + ES + + +LN+L FD +++ F V K++TIG +M SGL
Sbjct: 879 FSDIVGFTALSAES--TPMQVVTLLNDLYTCFDAVIDN--FD-VYKVETIGDAYMVVSGL 933
Query: 481 NPDLRHASRGTYDHLYQLMDFALEMQKVVDNFN--HDLFEFDFILRIGYNFGDVTAGVIG 538
R H ++ AL + V +F H E LRIG + G V AGV+G
Sbjct: 934 ------PVRNGRLHACEVARMALALLDAVRSFRIRHRPQE-QLRLRIGIHTGPVCAGVVG 986
Query: 539 TTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLS--ARYEFEPRGSVYVKGKDDM 596
Y ++GD VN ASRM+S G +I + VL +E E RG V +KGK +
Sbjct: 987 LKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKV 1046
Query: 597 NVYLLVGKK 605
Y L+G++
Sbjct: 1047 RTYWLLGER 1055
>AF038499-1|AAD09440.2| 617|Homo sapiens soluble guanylyl cyclase
subunit beta 2 protein.
Length = 617
Score = 94.3 bits (224), Expect = 1e-18
Identities = 60/220 (27%), Positives = 109/220 (49%), Gaps = 14/220 (6%)
Query: 385 RNQADWLLHNIIPRHVADQLKNTAKYSENH-KDVAIIFASIINFNEMYDESYLKGKEYLR 443
+ + + LL+ ++P+HVA+QL+ K + K I+F+ ++ F + + + + +
Sbjct: 357 KKKTETLLYAMLPKHVANQLREGKKVAAGEFKSCTILFSDVVTFTNIC--TACEPIQIVN 414
Query: 444 ILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFAL 503
+LN + + FD L V K++TIG +M G+ + + H ++ +FAL
Sbjct: 415 VLNSMYSKFDRLTS---VHAVYKVETIGDAYMVVGGVPVPIGN-------HAQRVANFAL 464
Query: 504 EMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVP 563
M+ + + LR+G + G V A V+G Y ++GD VN ASRM+S G+P
Sbjct: 465 GMRISAKEVTNPVTGEPIQLRVGIHTGPVLADVVGDKMPRYCLFGDTVNTASRMESHGLP 524
Query: 564 QRIQVGEACVPVLSAR-YEFEPRGSVYVKGKDDMNVYLLV 602
++ + L + ++ RG + VKGK M Y L+
Sbjct: 525 NKVHLSPTAYRALKNQGFKIIERGEIEVKGKGRMTTYFLI 564
>S72628-1|AAD14112.1| 415|Homo sapiens atrial natriuretic peptide
receptor guanylate protein.
Length = 415
Score = 93.1 bits (221), Expect = 3e-18
Identities = 78/237 (32%), Positives = 116/237 (48%), Gaps = 20/237 (8%)
Query: 365 RLSFYSNVVANRDKQRVQ---NMRNQADWLLHNIIPRHVADQLKN-TAKYSENHKDVAII 420
R+ Y+N + ++R Q + +A+ LL+ I+P VA+QLK +E V I
Sbjct: 186 RMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIY 245
Query: 421 FASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL 480
F+ I+ F + ES + + +LN+L FD +++ F V K++TIG +M SGL
Sbjct: 246 FSDIVGFTALSAES--TPMQVVTLLNDLYTCFDAVIDN--FD-VYKVETIGDAYMVVSGL 300
Query: 481 NPDLRHASRGTYDHLYQLMDFALEMQKVVDNFN--HDLFEFDFILRIGYNFGDVTAGVIG 538
R H ++ AL + V +F H E LRIG + G V AGV+G
Sbjct: 301 ------PVRNGRLHACEVARMALALLDAVRSFRIRHRPQE-QLRLRIGIHTGPVCAGVVG 353
Query: 539 TTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLS--ARYEFEPRGSVYVKGK 593
Y ++GD VN ASRM+S G +I + VL +E E RG V +KGK
Sbjct: 354 LKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGK 410
>X66533-1|CAA47144.1| 619|Homo sapiens guanylate cyclase protein.
Length = 619
Score = 92.7 bits (220), Expect = 3e-18
Identities = 72/263 (27%), Positives = 136/263 (51%), Gaps = 25/263 (9%)
Query: 359 EFEISYRLSFYSNVVANRDK---QRVQNMRNQADWLLHNIIPRHVADQLKNTAKY-SENH 414
+F Y+L+ ++ +R + + +++ + + D LL++++P VA++L++ ++ +
Sbjct: 358 QFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRY 417
Query: 415 KDVAIIFASIINFNEMYDESYLKGKEYLRI---LNELIADFDELLERPQFQHVEKIKTIG 471
+V I+F+ I+ FN + + G+ ++I LN+L FD L + + V K++T+G
Sbjct: 418 DNVTILFSGIVGFNA-FCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVG 476
Query: 472 STFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGD 531
+M SGL H +R +M+ A ++Q VD + + IG + G+
Sbjct: 477 DKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQ--VDGESVQI-------TIGIHTGE 527
Query: 532 VTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSA------RYEFEPR 585
V GVIG Y ++G+ VN+ SR ++TG +I V E L + ++ E R
Sbjct: 528 VVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHR 587
Query: 586 GSVYVKG-KDDMNVYLLVGKKDT 607
G V +KG K+ M V+ L +K+T
Sbjct: 588 GPVSMKGKKEPMQVWFL-SRKNT 609
>BC047620-1|AAH47620.2| 619|Homo sapiens guanylate cyclase 1,
soluble, beta 3 protein.
Length = 619
Score = 92.7 bits (220), Expect = 3e-18
Identities = 72/263 (27%), Positives = 136/263 (51%), Gaps = 25/263 (9%)
Query: 359 EFEISYRLSFYSNVVANRDK---QRVQNMRNQADWLLHNIIPRHVADQLKNTAKY-SENH 414
+F Y+L+ ++ +R + + +++ + + D LL++++P VA++L++ ++ +
Sbjct: 358 QFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRY 417
Query: 415 KDVAIIFASIINFNEMYDESYLKGKEYLRI---LNELIADFDELLERPQFQHVEKIKTIG 471
+V I+F+ I+ FN + + G+ ++I LN+L FD L + + V K++T+G
Sbjct: 418 DNVTILFSGIVGFNA-FCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVG 476
Query: 472 STFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGD 531
+M SGL H +R +M+ A ++Q VD + + IG + G+
Sbjct: 477 DKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQ--VDGESVQI-------TIGIHTGE 527
Query: 532 VTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSA------RYEFEPR 585
V GVIG Y ++G+ VN+ SR ++TG +I V E L + ++ E R
Sbjct: 528 VVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHR 587
Query: 586 GSVYVKG-KDDMNVYLLVGKKDT 607
G V +KG K+ M V+ L +K+T
Sbjct: 588 GPVSMKGKKEPMQVWFL-SRKNT 609
>BC015982-1|AAH15982.2| 130|Homo sapiens ADCY4 protein protein.
Length = 130
Score = 88.2 bits (209), Expect = 7e-17
Identities = 50/109 (45%), Positives = 64/109 (58%), Gaps = 2/109 (1%)
Query: 494 HLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNI 553
HL +++FA+ + +D N F +F LR+G N G V AGVIG K YDIWG+ VN+
Sbjct: 8 HLGTMVEFAVALGSKLDVINKHSFN-NFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNV 66
Query: 554 ASRMDSTGVPQRIQVGEACVPVL-SARYEFEPRGSVYVKGKDDMNVYLL 601
ASRM+STGV +IQV E L S Y RG + VKGK + Y L
Sbjct: 67 ASRMESTGVLGKIQVTEETAWALQSLGYTCYSRGVIKVKGKGQLCTYFL 115
>AL713889-5|CAI13614.1| 255|Homo sapiens natriuretic peptide
receptor A/guanylate cyclase A (atrionatriuretic peptide
re protein.
Length = 255
Score = 87.0 bits (206), Expect = 2e-16
Identities = 75/231 (32%), Positives = 112/231 (48%), Gaps = 20/231 (8%)
Query: 369 YSNVVANRDKQRVQ---NMRNQADWLLHNIIPRHVADQLKN-TAKYSENHKDVAIIFASI 424
Y+N + ++R Q + +A+ LL+ I+P VA+QLK +E V I F+ I
Sbjct: 4 YANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDI 63
Query: 425 INFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDL 484
+ F + ES + + +LN+L FD +++ F V K++TIG +M SGL
Sbjct: 64 VGFTALSAES--TPMQVVTLLNDLYTCFDAVIDN--FD-VYKVETIGDAYMVVSGL---- 114
Query: 485 RHASRGTYDHLYQLMDFALEMQKVVDNFN--HDLFEFDFILRIGYNFGDVTAGVIGTTKL 542
R H ++ AL + V +F H E LRIG + G V AGV+G
Sbjct: 115 --PVRNGRLHACEVARMALALLDAVRSFRIRHRPQE-QLRLRIGIHTGPVCAGVVGLKMP 171
Query: 543 YYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLS--ARYEFEPRGSVYVK 591
Y ++GD VN ASRM+S G +I + VL +E E RG V +K
Sbjct: 172 RYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMK 222
>BC039891-1|AAH39891.1| 433|Homo sapiens ADCY7 protein protein.
Length = 433
Score = 83.0 bits (196), Expect = 3e-15
Identities = 48/162 (29%), Positives = 84/162 (51%), Gaps = 13/162 (8%)
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
Y + H++V+I++A I+ F ++ + KE + +LNEL FD++ + + +IK
Sbjct: 271 YVKRHQNVSILYADIVGFTQLASDC--SPKELVVVLNELFGKFDQIAKANECM---RIKI 325
Query: 470 IGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFILRIGYNF 529
+G + SGL L H + L+M + + + D +R+G +
Sbjct: 326 LGDCYYCVSGLPVSLP-------THARNCVKMGLDMCQAIKQVR-EATGVDINMRVGIHS 377
Query: 530 GDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEA 571
G+V GVIG K YD+W V++A+RM++ GVP R+ + EA
Sbjct: 378 GNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEA 419
>AF020340-1|AAB94877.1| 586|Homo sapiens soluble guanylate cyclase
beta-1 subunit protein.
Length = 586
Score = 71.3 bits (167), Expect = 9e-12
Identities = 63/218 (28%), Positives = 105/218 (48%), Gaps = 23/218 (10%)
Query: 400 VADQLKNTAKYSENHKDVAIIFASIINFNEMYDESYLKGKEYLRI---LNELIADFDELL 456
+ D+L+ T + E+ K I+ FN + + G+ ++I LN+L FD L
Sbjct: 372 LTDRLQLTLRALEDEKKKTD--TGIVGFNA-FCSKHASGEGAMKIVNLLNDLYTRFDTLT 428
Query: 457 ERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDL 516
+ + V K++T+G +M SGL H +R +M+ A ++Q VD + +
Sbjct: 429 DSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQ--VDGESVQI 486
Query: 517 FEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVL 576
IG + G+V GVIG Y ++G+ VN+ SR ++TG +I V E L
Sbjct: 487 -------TIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCL 539
Query: 577 SA------RYEFEPRGSVYVKG-KDDMNVYLLVGKKDT 607
+ ++ E RG V +KG K+ M V+ L +K+T
Sbjct: 540 MSPENSDPQFHLEHRGPVSMKGKKEPMQVWFL-SRKNT 576
>X63282-1|CAA44921.1| 732|Homo sapiens alpha2-subunit of soluble
guanylyl cyclase protein.
Length = 732
Score = 66.5 bits (155), Expect = 3e-10
Identities = 56/209 (26%), Positives = 97/209 (46%), Gaps = 16/209 (7%)
Query: 376 RDKQRVQNMRNQADWLLHNIIPRHVADQL-KNTAKYSENHKDVAIIFASIINFNEMYDES 434
R Q ++ + + LL++I P VA QL + + DV ++F+ I+ F + +
Sbjct: 478 RTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQC 537
Query: 435 YLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDH 494
+ + +LNEL FD + F + K++TIG + A+GL+ R + H
Sbjct: 538 --TPMQVISMLNELYTRFDH---QCGFLDIYKVETIGDAYCVAAGLH-------RKSLCH 585
Query: 495 LYQLMDFALEMQKVVDN-FNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNI 553
+ AL+M ++ + D +RIG + G V AGV+G Y ++G+ V +
Sbjct: 586 AKPIALMALKMMELSEEVLTPDGRPIQ--MRIGIHSGSVLAGVVGVRMPRYCLFGNNVTL 643
Query: 554 ASRMDSTGVPQRIQVGEACVPVLSARYEF 582
AS+ +S P+RI V +L F
Sbjct: 644 ASKFESGSHPRRINVSPTTYQLLKREESF 672
>BC130488-1|AAI30489.1| 732|Homo sapiens guanylate cyclase 1,
soluble, alpha 2 protein.
Length = 732
Score = 66.5 bits (155), Expect = 3e-10
Identities = 56/209 (26%), Positives = 97/209 (46%), Gaps = 16/209 (7%)
Query: 376 RDKQRVQNMRNQADWLLHNIIPRHVADQL-KNTAKYSENHKDVAIIFASIINFNEMYDES 434
R Q ++ + + LL++I P VA QL + + DV ++F+ I+ F + +
Sbjct: 478 RTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQC 537
Query: 435 YLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDH 494
+ + +LNEL FD + F + K++TIG + A+GL+ R + H
Sbjct: 538 --TPMQVISMLNELYTRFDH---QCGFLDIYKVETIGDAYCVAAGLH-------RKSLCH 585
Query: 495 LYQLMDFALEMQKVVDN-FNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNI 553
+ AL+M ++ + D +RIG + G V AGV+G Y ++G+ V +
Sbjct: 586 AKPIALMALKMMELSEEVLTPDGRPIQ--MRIGIHSGSVLAGVVGVRMPRYCLFGNNVTL 643
Query: 554 ASRMDSTGVPQRIQVGEACVPVLSARYEF 582
AS+ +S P+RI V +L F
Sbjct: 644 ASKFESGSHPRRINVSPTTYQLLKREESF 672
>BC130484-1|AAI30485.1| 732|Homo sapiens guanylate cyclase 1,
soluble, alpha 2 protein.
Length = 732
Score = 66.5 bits (155), Expect = 3e-10
Identities = 56/209 (26%), Positives = 97/209 (46%), Gaps = 16/209 (7%)
Query: 376 RDKQRVQNMRNQADWLLHNIIPRHVADQL-KNTAKYSENHKDVAIIFASIINFNEMYDES 434
R Q ++ + + LL++I P VA QL + + DV ++F+ I+ F + +
Sbjct: 478 RTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQC 537
Query: 435 YLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDH 494
+ + +LNEL FD + F + K++TIG + A+GL+ R + H
Sbjct: 538 --TPMQVISMLNELYTRFDH---QCGFLDIYKVETIGDAYCVAAGLH-------RKSLCH 585
Query: 495 LYQLMDFALEMQKVVDN-FNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNI 553
+ AL+M ++ + D +RIG + G V AGV+G Y ++G+ V +
Sbjct: 586 AKPIALMALKMMELSEEVLTPDGRPIQ--MRIGIHSGSVLAGVVGVRMPRYCLFGNNVTL 643
Query: 554 ASRMDSTGVPQRIQVGEACVPVLSARYEF 582
AS+ +S P+RI V +L F
Sbjct: 644 ASKFESGSHPRRINVSPTTYQLLKREESF 672
>Y15723-1|CAA75738.1| 690|Homo sapiens soluble guanylyl cyclase
protein.
Length = 690
Score = 66.1 bits (154), Expect = 3e-10
Identities = 58/210 (27%), Positives = 97/210 (46%), Gaps = 16/210 (7%)
Query: 379 QRVQNMRNQADWLLHNIIPRHVADQL-KNTAKYSENHKDVAIIFASIINFNEMYDESYLK 437
Q ++ + + LL +I P VA QL + ++ +V ++F+ I+ F + S
Sbjct: 441 QALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAIC--SQCS 498
Query: 438 GKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQ 497
+ + +LN L FD+ V K++TIG + A GL H T H Q
Sbjct: 499 PLQVITMLNALYTRFDQQCGELD---VYKVETIGDAYCVAGGL-----HKESDT--HAVQ 548
Query: 498 LMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRM 557
+ AL+M ++ D E +RIG + G V AGV+G Y ++G+ V +A++
Sbjct: 549 IALMALKMMELSDEVMSPHGE-PIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKF 607
Query: 558 DSTGVPQRIQVGEACVPVLS--ARYEFEPR 585
+S VP++I V +L + F PR
Sbjct: 608 ESCSVPRKINVSPTTYRLLKDCPGFVFTPR 637
>U58855-1|AAB94794.1| 690|Homo sapiens soluble guanylate cyclase
large subunit protein.
Length = 690
Score = 66.1 bits (154), Expect = 3e-10
Identities = 58/210 (27%), Positives = 97/210 (46%), Gaps = 16/210 (7%)
Query: 379 QRVQNMRNQADWLLHNIIPRHVADQL-KNTAKYSENHKDVAIIFASIINFNEMYDESYLK 437
Q ++ + + LL +I P VA QL + ++ +V ++F+ I+ F + S
Sbjct: 441 QALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAIC--SQCS 498
Query: 438 GKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQ 497
+ + +LN L FD+ V K++TIG + A GL H T H Q
Sbjct: 499 PLQVITMLNALYTRFDQQCGELD---VYKVETIGDAYCVAGGL-----HKESDT--HAVQ 548
Query: 498 LMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRM 557
+ AL+M ++ D E +RIG + G V AGV+G Y ++G+ V +A++
Sbjct: 549 IALMALKMMELSDEVMSPHGE-PIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKF 607
Query: 558 DSTGVPQRIQVGEACVPVLS--ARYEFEPR 585
+S VP++I V +L + F PR
Sbjct: 608 ESCSVPRKINVSPTTYRLLKDCPGFVFTPR 637
>AF233750-1|AAF64043.1| 564|Homo sapiens soluble guanylate cyclase
large subunit protein.
Length = 564
Score = 66.1 bits (154), Expect = 3e-10
Identities = 58/210 (27%), Positives = 97/210 (46%), Gaps = 16/210 (7%)
Query: 379 QRVQNMRNQADWLLHNIIPRHVADQL-KNTAKYSENHKDVAIIFASIINFNEMYDESYLK 437
Q ++ + + LL +I P VA QL + ++ +V ++F+ I+ F + S
Sbjct: 315 QALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAIC--SQCS 372
Query: 438 GKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQ 497
+ + +LN L FD+ V K++TIG + A GL H T H Q
Sbjct: 373 PLQVITMLNALYTRFDQQCGELD---VYKVETIGDAYCVAGGL-----HKESDT--HAVQ 422
Query: 498 LMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRM 557
+ AL+M ++ D E +RIG + G V AGV+G Y ++G+ V +A++
Sbjct: 423 IALMALKMMELSDEVMSPHGE-PIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKF 481
Query: 558 DSTGVPQRIQVGEACVPVLS--ARYEFEPR 585
+S VP++I V +L + F PR
Sbjct: 482 ESCSVPRKINVSPTTYRLLKDCPGFVFTPR 511
>BC028384-1|AAH28384.1| 690|Homo sapiens GUCY1A3 protein protein.
Length = 690
Score = 64.9 bits (151), Expect = 8e-10
Identities = 57/210 (27%), Positives = 97/210 (46%), Gaps = 16/210 (7%)
Query: 379 QRVQNMRNQADWLLHNIIPRHVADQL-KNTAKYSENHKDVAIIFASIINFNEMYDESYLK 437
Q ++ + + LL +I P VA QL + ++ +V ++F+ I+ F + S
Sbjct: 441 QALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAIC--SQCS 498
Query: 438 GKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQ 497
+ + +LN L FD+ V K++TIG + A GL H T H Q
Sbjct: 499 PLQVITMLNALYTRFDQQCGELD---VYKVETIGDAYCVAGGL-----HKESDT--HAVQ 548
Query: 498 LMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRM 557
+ A++M ++ D E +RIG + G V AGV+G Y ++G+ V +A++
Sbjct: 549 IALMAVKMMELSDEVMSPHGE-PIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKF 607
Query: 558 DSTGVPQRIQVGEACVPVLS--ARYEFEPR 585
+S VP++I V +L + F PR
Sbjct: 608 ESCSVPRKINVSPTTYRLLKDCPGFVFTPR 637
>X66534-1|CAA47145.1| 717|Homo sapiens guanylate cyclase protein.
Length = 717
Score = 59.3 bits (137), Expect = 4e-08
Identities = 56/210 (26%), Positives = 95/210 (45%), Gaps = 16/210 (7%)
Query: 379 QRVQNMRNQADWLLHNIIPRHVADQL-KNTAKYSENHKDVAIIFASIINFNEMYDESYLK 437
Q ++ + + LL +I P VA QL + ++ +V ++F+ I+ F + S
Sbjct: 438 QALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAIC--SQCS 495
Query: 438 GKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLNPDLRHASRGTYDHLYQ 497
+ + +LN L FD+ V K++TI + GL H T H Q
Sbjct: 496 PLQVITMLNALYTRFDQQCGELD---VYKVETIAMPIVWLGGL-----HKESDT--HAVQ 545
Query: 498 LMDFALEMQKVVDNFNHDLFEFDFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRM 557
+ AL+M ++ D E +RIG + G V AGV+G Y ++G+ V +A++
Sbjct: 546 IALMALKMMELSDEVMSPHGE-PIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKF 604
Query: 558 DSTGVPQRIQVGEACVPVLS--ARYEFEPR 585
+S VP++I V +L + F PR
Sbjct: 605 ESCSVPRKINVSPTTYRLLKDCPGFVFTPR 634
>Z50053-1|CAA90393.1| 763|Homo sapiens alpha2i-subunit of soluble
guanylyl cyclase protein.
Length = 763
Score = 57.6 bits (133), Expect = 1e-07
Identities = 59/231 (25%), Positives = 99/231 (42%), Gaps = 29/231 (12%)
Query: 376 RDKQRVQNMRNQADWLLHNIIPRHVADQL-KNTAKYSENHKDVAIIFASIINFNEMYDES 434
R Q ++ + + LL++I P VA QL + + DV ++F+ I+ F + +
Sbjct: 478 RTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQC 537
Query: 435 YLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLN-PDLRHAS----- 488
+ + +LNEL FD + F + K++TIG + A+GL+ L HA
Sbjct: 538 --TPMQVISMLNELYTRFDH---QCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIALM 592
Query: 489 ----------------RGTYDHLYQLM-DFALEMQKVVDNFNHDLFEFDFILRIGYNFGD 531
R +L+ F + +Q V D + +RIG + G
Sbjct: 593 ALKMMELSEEVLTPDGRPIQPQRSELLFSFPVSIQLVPDQHQSETDLGTEKMRIGIHSGS 652
Query: 532 VTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEF 582
V AGV+G Y ++G+ V +AS+ +S P+RI V +L F
Sbjct: 653 VLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKREESF 703
>AK126468-1|BAC86560.1| 419|Homo sapiens protein ( Homo sapiens
cDNA FLJ44504 fis, clone UTERU3001240, highly similar
to Adenylate cyclase, type IV (EC 4.6.1.1). ).
Length = 419
Score = 56.8 bits (131), Expect = 2e-07
Identities = 25/67 (37%), Positives = 38/67 (56%)
Query: 520 DFILRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSAR 579
D +R+G + G V GVIG K YD+W V +A+ M++ GVP R+ + A + +L+
Sbjct: 55 DINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGA 114
Query: 580 YEFEPRG 586
Y E G
Sbjct: 115 YAVEDAG 121
>AJ005282-1|CAA06466.1| 995|Homo sapiens NPR-Bi protein.
Length = 995
Score = 55.2 bits (127), Expect = 6e-07
Identities = 50/171 (29%), Positives = 81/171 (47%), Gaps = 16/171 (9%)
Query: 365 RLSFYSNVVANRDKQRVQ---NMRNQADWLLHNIIPRHVADQLK-NTAKYSENHKDVAII 420
R+ Y+N + ++R Q + +A+ LL+ I+P VA+QLK +E V I
Sbjct: 804 RMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIY 863
Query: 421 FASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGL 480
F+ I+ F + ES + + +LN+L FD +++ F V K++TIG +M SGL
Sbjct: 864 FSDIVGFTALSAES--TPMQVVTLLNDLYTCFDAIID--NFD-VYKVETIGDAYMVVSGL 918
Query: 481 NPDLRHASRGTYDHLYQLMDFALEMQKVVDNFNHDLFEFDFI-LRIGYNFG 530
R H ++ AL + V +F D + LRIG + G
Sbjct: 919 ------PGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTG 963
>U65473-1|AAD00121.1| 105|Homo sapiens adenylyl cyclase type V
protein.
Length = 105
Score = 50.8 bits (116), Expect = 1e-05
Identities = 22/62 (35%), Positives = 37/62 (59%)
Query: 523 LRIGYNFGDVTAGVIGTTKLYYDIWGDAVNIASRMDSTGVPQRIQVGEACVPVLSARYEF 582
+R+G + G V GV+G K +D+W + V +A+ M++ G RI + +A + L+ YE
Sbjct: 2 MRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEV 61
Query: 583 EP 584
EP
Sbjct: 62 EP 63
>AC069008-1|AAS07467.1| 105|Homo sapiens unknown protein.
Length = 105
Score = 49.2 bits (112), Expect = 4e-05
Identities = 28/79 (35%), Positives = 41/79 (51%), Gaps = 6/79 (7%)
Query: 410 YSENHKDVAIIFASIINFNEMYDESYLKGKEYLRILNELIADFDELLERPQFQHVEKIKT 469
Y + H +V+I+FA I+ F + S +E +++LNEL FDEL H +IK
Sbjct: 17 YIQRHDNVSILFADIVGFTGL--ASQCTAQELVKLLNELFGKFDELATE---NHCRRIKI 71
Query: 470 IGSTFMAASGL-NPDLRHA 487
+G + SGL P HA
Sbjct: 72 LGDCYYCVSGLTQPKTDHA 90
>AL160157-1|CAI15432.2| 385|Homo sapiens guanylate cyclase 1,
soluble, beta 2 protein.
Length = 385
Score = 47.6 bits (108), Expect = 1e-04
Identities = 29/107 (27%), Positives = 55/107 (51%), Gaps = 7/107 (6%)
Query: 385 RNQADWLLHNIIPRHVADQLKNTAKYSENH-KDVAIIFASIINFNEMYDESYLKGKEYLR 443
+ + + LL+ ++P+HVA+QL+ K + K I+F+ ++ F + + + + +
Sbjct: 255 KKKTETLLYAMLPKHVANQLREGKKVAAGEFKSCTILFSDVVTFTNIC--TACEPIQIVN 312
Query: 444 ILNELIADFDELLERPQFQHVEKIKTIGSTFMAASGLN-PDLRHASR 489
+LN + + FD L V K++TIG +M G+ P HA R
Sbjct: 313 VLNSMYSKFDRL---TSVHAVYKVETIGDAYMVVGGVPVPIGNHAQR 356
>L26921-1|AAA60366.1| 80|Homo sapiens guanyl cyclase protein.
Length = 80
Score = 37.9 bits (84), Expect = 0.10
Identities = 21/52 (40%), Positives = 31/52 (59%), Gaps = 3/52 (5%)
Query: 557 MDSTGVPQRIQVGEACVPVLSAR---YEFEPRGSVYVKGKDDMNVYLLVGKK 605
M+STG+P RI V + V +L A Y+ E RG +KGK + + LVG++
Sbjct: 1 MESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVGRR 52
>AY260762-1|AAP20225.1| 3567|Homo sapiens zinc finger homeodomain 4
protein protein.
Length = 3567
Score = 33.1 bits (72), Expect = 2.9
Identities = 19/64 (29%), Positives = 30/64 (46%), Gaps = 2/64 (3%)
Query: 3 QIFALNHIANSQNDMLQHRVSGYYTSSQSSLNDLHSKSRLPPPLNDQQVQSLQKLRKQSD 62
QI +H+ +Q +LQ + Y ++Q L + + PPP QQ Q KL KQ
Sbjct: 1736 QIQTQHHVGQTQLQILQQQAQ-QYQATQPQLQP-QKQQQQPPPPQQQQQQQASKLLKQEQ 1793
Query: 63 LQLI 66
++
Sbjct: 1794 SNIV 1797
>AB083343-1|BAE96598.1| 3599|Homo sapiens zinc-finger homeodomain
protein 4 protein.
Length = 3599
Score = 33.1 bits (72), Expect = 2.9
Identities = 19/64 (29%), Positives = 30/64 (46%), Gaps = 2/64 (3%)
Query: 3 QIFALNHIANSQNDMLQHRVSGYYTSSQSSLNDLHSKSRLPPPLNDQQVQSLQKLRKQSD 62
QI +H+ +Q +LQ + Y ++Q L + + PPP QQ Q KL KQ
Sbjct: 1781 QIQTQHHVGQTQLQILQQQAQ-QYQATQPQLQP-QKQQQQPPPPQQQQQQQASKLLKQEQ 1838
Query: 63 LQLI 66
++
Sbjct: 1839 SNIV 1842
>X63118-1|CAA44831.1| 153|Homo sapiens ORF protein.
Length = 153
Score = 32.3 bits (70), Expect = 5.1
Identities = 16/48 (33%), Positives = 26/48 (54%)
Query: 181 THHDPRSVAETFHDSLKIFRKLSDWYPWHLSGGLMISLPILIVLINFS 228
+H +P + A TF S + R L+ PW++SG + +VLI+ S
Sbjct: 101 SHTEPLAHASTFLPSFSLSRPLTSTSPWNISGKTFLIQQGRLVLISLS 148
>AK131333-1|BAD18492.1| 174|Homo sapiens 9. protein.
Length = 174
Score = 32.3 bits (70), Expect = 5.1
Identities = 16/56 (28%), Positives = 27/56 (48%)
Query: 358 REFEISYRLSFYSNVVANRDKQRVQNMRNQADWLLHNIIPRHVADQLKNTAKYSEN 413
R+ E RL F ++++ + M N LL N++P HVA Q + +E+
Sbjct: 108 RQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNES 163
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.324 0.138 0.423
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 85,441,557
Number of Sequences: 224733
Number of extensions: 3503107
Number of successful extensions: 9315
Number of sequences better than 10.0: 73
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 8975
Number of HSP's gapped (non-prelim): 129
length of query: 607
length of database: 73,234,838
effective HSP length: 94
effective length of query: 513
effective length of database: 52,109,936
effective search space: 26732397168
effective search space used: 26732397168
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 40 (21.5 bits)
S2: 68 (31.5 bits)
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