Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001254-TA|BGIBMGA001254-PA|IPR001054|Adenylyl cyclase
class-3/4/guanylyl cyclase
(705 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
DQ008441-1|AAY27880.1| 1353|Homo sapiens adenylyl cyclase type 9... 170 1e-41
DQ005545-1|AAY21237.1| 1353|Homo sapiens adenylyl cyclase type 9... 170 1e-41
AY028959-1|AAK29464.1| 1353|Homo sapiens adenylate cyclase type ... 170 1e-41
AJ133123-1|CAB65084.1| 1353|Homo sapiens adenylyl cyclase type I... 170 1e-41
AF036927-1|AAC24201.1| 1294|Homo sapiens adenylyl cyclase type I... 170 1e-41
AB011092-1|BAA25446.3| 1364|Homo sapiens KIAA0520 protein protein. 170 1e-41
BC111743-1|AAI11744.1| 1091|Homo sapiens adenylate cyclase 2 (br... 102 4e-21
AF410885-1|AAP97285.1| 1091|Homo sapiens adenylyl cyclase type I... 102 4e-21
AB028983-1|BAA83012.1| 887|Homo sapiens KIAA1060 protein protein. 102 4e-21
BC064923-1|AAH64923.1| 1168|Homo sapiens ADCY6 protein protein. 99 3e-20
AF250226-1|AAF82478.1| 1168|Homo sapiens adenylyl cyclase type V... 99 3e-20
AB007882-1|BAA24852.2| 1160|Homo sapiens KIAA0422 protein. 99 3e-20
AF497517-1|AAM94374.1| 894|Homo sapiens adenylate cyclase type ... 100 4e-20
D25538-1|BAA05021.2| 1088|Homo sapiens KIAA0037 protein. 99 5e-20
BC126271-1|AAI26272.1| 1080|Homo sapiens adenylate cyclase 7 pro... 99 5e-20
BC126235-1|AAI26236.1| 1144|Homo sapiens adenylate cyclase 3 pro... 99 6e-20
AF033861-1|AAD13403.1| 1144|Homo sapiens type III adenylyl cycla... 99 6e-20
AC012073-2|AAY14787.1| 1144|Homo sapiens unknown protein. 99 6e-20
AB011083-1|BAA25437.1| 933|Homo sapiens KIAA0511 protein protein. 99 6e-20
BC117475-1|AAI17476.1| 1077|Homo sapiens adenylate cyclase 4 pro... 97 2e-19
BC117473-1|AAI17474.1| 1077|Homo sapiens adenylate cyclase 4 pro... 97 2e-19
AF497516-1|AAM94373.1| 1077|Homo sapiens adenylate cyclase type ... 97 2e-19
DQ104739-1|AAZ13596.1| 1120|Homo sapiens brain adenylate cyclase... 97 2e-19
Z35309-1|CAA84552.1| 1251|Homo sapiens adenylyl cyclase protein. 95 8e-19
L05500-1|AAA02907.1| 839|Homo sapiens adenylyl cyclase protein. 95 1e-18
BC039891-1|AAH39891.1| 433|Homo sapiens ADCY7 protein protein. 95 1e-18
AB209496-1|BAD92733.1| 1045|Homo sapiens brain adenylate cyclase... 95 1e-18
AK126468-1|BAC86560.1| 419|Homo sapiens protein ( Homo sapiens ... 92 5e-18
U65473-1|AAD00121.1| 105|Homo sapiens adenylyl cyclase type V p... 91 9e-18
M83533-1|AAA35523.2| 675|Homo sapiens adenylyl cyclase type V p... 66 5e-10
X63282-1|CAA44921.1| 732|Homo sapiens alpha2-subunit of soluble... 64 2e-09
BC130488-1|AAI30489.1| 732|Homo sapiens guanylate cyclase 1, so... 64 2e-09
BC130484-1|AAI30485.1| 732|Homo sapiens guanylate cyclase 1, so... 64 2e-09
Y15723-1|CAA75738.1| 690|Homo sapiens soluble guanylyl cyclase ... 61 2e-08
X66534-1|CAA47145.1| 717|Homo sapiens guanylate cyclase protein. 61 2e-08
U58855-1|AAB94794.1| 690|Homo sapiens soluble guanylate cyclase... 61 2e-08
BC028384-1|AAH28384.1| 690|Homo sapiens GUCY1A3 protein protein. 61 2e-08
AF233750-1|AAF64043.1| 564|Homo sapiens soluble guanylate cycla... 61 2e-08
AK075424-1|BAC11613.1| 378|Homo sapiens protein ( Homo sapiens ... 59 5e-08
AF038499-1|AAD09440.2| 617|Homo sapiens soluble guanylyl cyclas... 59 6e-08
BC015982-1|AAH15982.2| 130|Homo sapiens ADCY4 protein protein. 58 8e-08
AK056745-1|BAB71270.1| 506|Homo sapiens protein ( Homo sapiens ... 58 8e-08
Z50053-1|CAA90393.1| 763|Homo sapiens alpha2i-subunit of solubl... 58 1e-07
X74210-1|CAA52282.1| 476|Homo sapiens adenylate cyclase protein. 56 4e-07
L21993-1|AAA64923.1| 476|Homo sapiens adenylyl cyclase protein. 56 4e-07
AF070583-1|AAC28647.1| 367|Homo sapiens adenylyl cyclase protein. 56 4e-07
X15357-1|CAA33417.1| 1061|Homo sapiens ANP-A receptor preprotein... 55 1e-06
S72628-1|AAD14112.1| 415|Homo sapiens atrial natriuretic peptid... 55 1e-06
BC063304-1|AAH63304.1| 1061|Homo sapiens natriuretic peptide rec... 55 1e-06
AL713889-5|CAI13614.1| 255|Homo sapiens natriuretic peptide rec... 55 1e-06
AL713889-4|CAI13613.1| 1061|Homo sapiens natriuretic peptide rec... 55 1e-06
AF190631-1|AAF01340.1| 1061|Homo sapiens natriuretic peptide rec... 55 1e-06
AB010491-1|BAA31199.1| 1061|Homo sapiens natriuretic peptide A t... 55 1e-06
X66533-1|CAA47144.1| 619|Homo sapiens guanylate cyclase protein. 54 1e-06
BC047620-1|AAH47620.2| 619|Homo sapiens guanylate cyclase 1, so... 54 1e-06
AF020340-1|AAB94877.1| 586|Homo sapiens soluble guanylate cycla... 54 1e-06
BC023017-1|AAH23017.1| 618|Homo sapiens NPR2 protein protein. 52 9e-06
AL133410-13|CAI10987.1| 1047|Homo sapiens natriuretic peptide re... 52 9e-06
AB005647-1|BAA81737.1| 1047|Homo sapiens atrial natriuretic pept... 52 9e-06
L37378-1|AAA74451.1| 1108|Homo sapiens guanylyl cyclase protein. 51 1e-05
AL031387-4|CAB41303.1| 1108|Homo sapiens guanylate cyclase 2F, r... 51 1e-05
S57551-1|AAB19934.2| 1073|Homo sapiens guanylate cyclase-coupled... 49 7e-05
M73489-1|AAA36655.1| 1073|Homo sapiens heat-stable enterotoxin r... 49 7e-05
M92432-1|AAA60547.1| 1103|Homo sapiens guanylyl cyclase protein. 46 6e-04
AJ222657-1|CAA10914.1| 1103|Homo sapiens guanylyl cyclase protein. 46 6e-04
U65474-1|AAD00122.1| 74|Homo sapiens adenylyl cyclase type VI ... 40 0.030
AC069008-1|AAS07467.1| 105|Homo sapiens unknown protein. 35 0.86
BC101476-1|AAI01477.1| 1015|Homo sapiens non-SMC condensin I com... 34 1.5
BC068467-1|AAH68467.1| 1015|Homo sapiens non-SMC condensin I com... 34 1.5
BC000827-1|AAH00827.1| 435|Homo sapiens NCAPG protein protein. 34 1.5
AK027511-1|BAB55165.1| 524|Homo sapiens protein ( Homo sapiens ... 34 1.5
AK023147-1|BAB14429.1| 960|Homo sapiens protein ( Homo sapiens ... 34 1.5
AK022512-1|BAB14069.1| 1015|Homo sapiens protein ( Homo sapiens ... 34 1.5
AF331796-1|AAG49627.1| 1015|Homo sapiens condensin subunit CAP-G... 34 1.5
AB013299-1|BAB21557.1| 1015|Homo sapiens chromosome-associated p... 34 1.5
AJ626861-1|CAF25188.1| 3628|Homo sapiens VPS13C-2B protein protein. 33 4.6
AJ626860-1|CAF25187.1| 3585|Homo sapiens VPS13C-1B protein protein. 33 4.6
AJ608771-1|CAE75583.1| 3753|Homo sapiens VPS13C-2A protein protein. 33 4.6
AJ608770-1|CAE75582.1| 3710|Homo sapiens VPS13C-1A protein protein. 33 4.6
AB037842-1|BAA92659.1| 1463|Homo sapiens KIAA1421 protein protein. 33 4.6
>DQ008441-1|AAY27880.1| 1353|Homo sapiens adenylyl cyclase type 9
protein.
Length = 1353
Score = 170 bits (414), Expect = 1e-41
Identities = 115/332 (34%), Positives = 164/332 (49%), Gaps = 18/332 (5%)
Query: 57 IPIAFERAAPGTWWNPRFDSEILEGQYRSSSFRQIRLRFRFALLYILIFSISWFVYFVV- 115
+P FERA+ WW+P+FDS LE F Q + RFR+AL YI + W +YF V
Sbjct: 79 LPQLFERAS-SRWWDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVH 137
Query: 116 LGLNDVTVKWPFLCSLFA--GVLLITCIMLLV---TFTNF-YKVYTFKLSLVMAXXXXXX 169
+ + + P LC L G L T L +T+ + F L+L
Sbjct: 138 MRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALTLLVFALTLAAQFQVLTP 197
Query: 170 XXXXXXXXXXXXXXFYQAADISQSGHFTMCIEXXXXXXXXXXXXXXACVILGIIYSIVFE 229
+SQ G F+MCIE + LG+ YS++FE
Sbjct: 198 VSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFE 257
Query: 230 VLNIVLHLSEQEWQASG-------MFVRILLQLCVHIIGVHIYLMTFVRMRGTFMKVGQS 282
E + + G + R LL C+H IGVH+++M+ VR R TF+KVGQS
Sbjct: 258 TFGYHFR-DEACFPSPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQS 316
Query: 283 LLVRRQLEMEKQLKEKMIHSVMPPKLASNLMNEQVTEADTNVKTY--HNPLNSRISNPGS 340
++ + LE+EK LKE+MIHSVMP +A +LM + E++ +VK + +P N + +
Sbjct: 317 IMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQ 376
Query: 341 DIKSLFRPFNMSCMDNVSILFADIVGFTRMSS 372
FRPF M ++ VSILFADIVGFT+MS+
Sbjct: 377 KAPIAFRPFKMQQIEEVSILFADIVGFTKMSA 408
Score = 114 bits (274), Expect = 1e-24
Identities = 51/83 (61%), Positives = 66/83 (79%)
Query: 373 MIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGR 432
MI+AI++F +E+ E +NMRVGVHTGTVLCGI+G RRFKFDVWSNDV AN ME G G+
Sbjct: 469 MIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGK 528
Query: 433 VHISEETSQFLGGSYILEEGEEV 455
VHISE T+++L Y +E+G+ +
Sbjct: 529 VHISEATAKYLDDRYEMEDGKVI 551
Score = 50.4 bits (115), Expect = 2e-05
Identities = 21/78 (26%), Positives = 43/78 (55%), Gaps = 1/78 (1%)
Query: 367 FTRMSSMIEAIQEFDRER-GEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKME 425
F M+ + +F+ +RVG + G + G++GT + +D+W + V A++M+
Sbjct: 1139 FEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMD 1198
Query: 426 SSGKPGRVHISEETSQFL 443
++G R+ +SEE+ + L
Sbjct: 1199 TTGVECRIQVSEESYRVL 1216
>DQ005545-1|AAY21237.1| 1353|Homo sapiens adenylyl cyclase type 9
protein.
Length = 1353
Score = 170 bits (414), Expect = 1e-41
Identities = 115/332 (34%), Positives = 164/332 (49%), Gaps = 18/332 (5%)
Query: 57 IPIAFERAAPGTWWNPRFDSEILEGQYRSSSFRQIRLRFRFALLYILIFSISWFVYFVV- 115
+P FERA+ WW+P+FDS LE F Q + RFR+AL YI + W +YF V
Sbjct: 79 LPQLFERAS-SRWWDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVH 137
Query: 116 LGLNDVTVKWPFLCSLFA--GVLLITCIMLLV---TFTNF-YKVYTFKLSLVMAXXXXXX 169
+ + + P LC L G L T L +T+ + F L+L
Sbjct: 138 MRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALTLLVFALTLAAQFQVLTP 197
Query: 170 XXXXXXXXXXXXXXFYQAADISQSGHFTMCIEXXXXXXXXXXXXXXACVILGIIYSIVFE 229
+SQ G F+MCIE + LG+ YS++FE
Sbjct: 198 VSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFE 257
Query: 230 VLNIVLHLSEQEWQASG-------MFVRILLQLCVHIIGVHIYLMTFVRMRGTFMKVGQS 282
E + + G + R LL C+H IGVH+++M+ VR R TF+KVGQS
Sbjct: 258 TFGYHFR-DEACFPSPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQS 316
Query: 283 LLVRRQLEMEKQLKEKMIHSVMPPKLASNLMNEQVTEADTNVKTY--HNPLNSRISNPGS 340
++ + LE+EK LKE+MIHSVMP +A +LM + E++ +VK + +P N + +
Sbjct: 317 IMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQ 376
Query: 341 DIKSLFRPFNMSCMDNVSILFADIVGFTRMSS 372
FRPF M ++ VSILFADIVGFT+MS+
Sbjct: 377 KAPIAFRPFKMQQIEEVSILFADIVGFTKMSA 408
Score = 114 bits (274), Expect = 1e-24
Identities = 51/83 (61%), Positives = 66/83 (79%)
Query: 373 MIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGR 432
MI+AI++F +E+ E +NMRVGVHTGTVLCGI+G RRFKFDVWSNDV AN ME G G+
Sbjct: 469 MIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGK 528
Query: 433 VHISEETSQFLGGSYILEEGEEV 455
VHISE T+++L Y +E+G+ +
Sbjct: 529 VHISEATAKYLDDRYEMEDGKVI 551
Score = 50.4 bits (115), Expect = 2e-05
Identities = 21/78 (26%), Positives = 43/78 (55%), Gaps = 1/78 (1%)
Query: 367 FTRMSSMIEAIQEFDRER-GEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKME 425
F M+ + +F+ +RVG + G + G++GT + +D+W + V A++M+
Sbjct: 1139 FEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMD 1198
Query: 426 SSGKPGRVHISEETSQFL 443
++G R+ +SEE+ + L
Sbjct: 1199 TTGVECRIQVSEESYRVL 1216
>AY028959-1|AAK29464.1| 1353|Homo sapiens adenylate cyclase type 9
protein.
Length = 1353
Score = 170 bits (414), Expect = 1e-41
Identities = 115/332 (34%), Positives = 164/332 (49%), Gaps = 18/332 (5%)
Query: 57 IPIAFERAAPGTWWNPRFDSEILEGQYRSSSFRQIRLRFRFALLYILIFSISWFVYFVV- 115
+P FERA+ WW+P+FDS LE F Q + RFR+AL YI + W +YF V
Sbjct: 79 LPQLFERAS-SRWWDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVH 137
Query: 116 LGLNDVTVKWPFLCSLFA--GVLLITCIMLLV---TFTNF-YKVYTFKLSLVMAXXXXXX 169
+ + + P LC L G L T L +T+ + F L+L
Sbjct: 138 MRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALTLLVFALTLAAQFQVLTP 197
Query: 170 XXXXXXXXXXXXXXFYQAADISQSGHFTMCIEXXXXXXXXXXXXXXACVILGIIYSIVFE 229
+SQ G F+MCIE + LG+ YS++FE
Sbjct: 198 VSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFE 257
Query: 230 VLNIVLHLSEQEWQASG-------MFVRILLQLCVHIIGVHIYLMTFVRMRGTFMKVGQS 282
E + + G + R LL C+H IGVH+++M+ VR R TF+KVGQS
Sbjct: 258 TFGYHFR-DEACFPSPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQS 316
Query: 283 LLVRRQLEMEKQLKEKMIHSVMPPKLASNLMNEQVTEADTNVKTY--HNPLNSRISNPGS 340
++ + LE+EK LKE+MIHSVMP +A +LM + E++ +VK + +P N + +
Sbjct: 317 IMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQ 376
Query: 341 DIKSLFRPFNMSCMDNVSILFADIVGFTRMSS 372
FRPF M ++ VSILFADIVGFT+MS+
Sbjct: 377 KAPIAFRPFKMQQIEEVSILFADIVGFTKMSA 408
Score = 114 bits (274), Expect = 1e-24
Identities = 51/83 (61%), Positives = 66/83 (79%)
Query: 373 MIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGR 432
MI+AI++F +E+ E +NMRVGVHTGTVLCGI+G RRFKFDVWSNDV AN ME G G+
Sbjct: 469 MIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGK 528
Query: 433 VHISEETSQFLGGSYILEEGEEV 455
VHISE T+++L Y +E+G+ +
Sbjct: 529 VHISEATAKYLDDRYEMEDGKVI 551
Score = 50.4 bits (115), Expect = 2e-05
Identities = 21/78 (26%), Positives = 43/78 (55%), Gaps = 1/78 (1%)
Query: 367 FTRMSSMIEAIQEFDRER-GEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKME 425
F M+ + +F+ +RVG + G + G++GT + +D+W + V A++M+
Sbjct: 1139 FEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMD 1198
Query: 426 SSGKPGRVHISEETSQFL 443
++G R+ +SEE+ + L
Sbjct: 1199 TTGVECRIQVSEESYRVL 1216
>AJ133123-1|CAB65084.1| 1353|Homo sapiens adenylyl cyclase type IX
protein.
Length = 1353
Score = 170 bits (414), Expect = 1e-41
Identities = 115/332 (34%), Positives = 164/332 (49%), Gaps = 18/332 (5%)
Query: 57 IPIAFERAAPGTWWNPRFDSEILEGQYRSSSFRQIRLRFRFALLYILIFSISWFVYFVV- 115
+P FERA+ WW+P+FDS LE F Q + RFR+AL YI + W +YF V
Sbjct: 79 LPQLFERAS-SRWWDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVH 137
Query: 116 LGLNDVTVKWPFLCSLFA--GVLLITCIMLLV---TFTNF-YKVYTFKLSLVMAXXXXXX 169
+ + + P LC L G L T L +T+ + F L+L
Sbjct: 138 MRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALTLLVFALTLAAQFQVLTP 197
Query: 170 XXXXXXXXXXXXXXFYQAADISQSGHFTMCIEXXXXXXXXXXXXXXACVILGIIYSIVFE 229
+SQ G F+MCIE + LG+ YS++FE
Sbjct: 198 VSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFE 257
Query: 230 VLNIVLHLSEQEWQASG-------MFVRILLQLCVHIIGVHIYLMTFVRMRGTFMKVGQS 282
E + + G + R LL C+H IGVH+++M+ VR R TF+KVGQS
Sbjct: 258 TFGYHFR-DEACFPSPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQS 316
Query: 283 LLVRRQLEMEKQLKEKMIHSVMPPKLASNLMNEQVTEADTNVKTY--HNPLNSRISNPGS 340
++ + LE+EK LKE+MIHSVMP +A +LM + E++ +VK + +P N + +
Sbjct: 317 IMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQ 376
Query: 341 DIKSLFRPFNMSCMDNVSILFADIVGFTRMSS 372
FRPF M ++ VSILFADIVGFT+MS+
Sbjct: 377 KAPIAFRPFKMQQIEEVSILFADIVGFTKMSA 408
Score = 111 bits (266), Expect = 1e-23
Identities = 50/83 (60%), Positives = 65/83 (78%)
Query: 373 MIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGR 432
MI+AI++F +E+ E +NMRVGVHT TVLCGI+G RRFKFDVWSNDV AN ME G G+
Sbjct: 469 MIKAIEQFCQEKKEMVNMRVGVHTRTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGK 528
Query: 433 VHISEETSQFLGGSYILEEGEEV 455
VHISE T+++L Y +E+G+ +
Sbjct: 529 VHISEATAKYLDDRYEMEDGKVI 551
Score = 50.0 bits (114), Expect = 3e-05
Identities = 21/78 (26%), Positives = 43/78 (55%), Gaps = 1/78 (1%)
Query: 367 FTRMSSMIEAIQEFDRER-GEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKME 425
F M+ + +F+ +RVG + G + G++GT + +D+W + V A++M+
Sbjct: 1139 FEFAKEMMRVVDDFNSNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMD 1198
Query: 426 SSGKPGRVHISEETSQFL 443
++G R+ +SEE+ + L
Sbjct: 1199 TTGVECRIQVSEESYRVL 1216
>AF036927-1|AAC24201.1| 1294|Homo sapiens adenylyl cyclase type IX
protein.
Length = 1294
Score = 170 bits (414), Expect = 1e-41
Identities = 115/332 (34%), Positives = 164/332 (49%), Gaps = 18/332 (5%)
Query: 57 IPIAFERAAPGTWWNPRFDSEILEGQYRSSSFRQIRLRFRFALLYILIFSISWFVYFVV- 115
+P FERA+ WW+P+FDS LE F Q + RFR+AL YI + W +YF V
Sbjct: 79 LPQLFERAS-SRWWDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVH 137
Query: 116 LGLNDVTVKWPFLCSLFA--GVLLITCIMLLV---TFTNF-YKVYTFKLSLVMAXXXXXX 169
+ + + P LC L G L T L +T+ + F L+L
Sbjct: 138 MRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALTLLVFALTLAAQFQVLTP 197
Query: 170 XXXXXXXXXXXXXXFYQAADISQSGHFTMCIEXXXXXXXXXXXXXXACVILGIIYSIVFE 229
+SQ G F+MCIE + LG+ YS++FE
Sbjct: 198 VSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFE 257
Query: 230 VLNIVLHLSEQEWQASG-------MFVRILLQLCVHIIGVHIYLMTFVRMRGTFMKVGQS 282
E + + G + R LL C+H IGVH+++M+ VR R TF+KVGQS
Sbjct: 258 TFGYHFR-DEACFPSPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQS 316
Query: 283 LLVRRQLEMEKQLKEKMIHSVMPPKLASNLMNEQVTEADTNVKTY--HNPLNSRISNPGS 340
++ + LE+EK LKE+MIHSVMP +A +LM + E++ +VK + +P N + +
Sbjct: 317 IMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQ 376
Query: 341 DIKSLFRPFNMSCMDNVSILFADIVGFTRMSS 372
FRPF M ++ VSILFADIVGFT+MS+
Sbjct: 377 KAPIAFRPFKMQQIEEVSILFADIVGFTKMSA 408
Score = 114 bits (274), Expect = 1e-24
Identities = 51/83 (61%), Positives = 66/83 (79%)
Query: 373 MIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGR 432
MI+AI++F +E+ E +NMRVGVHTGTVLCGI+G RRFKFDVWSNDV AN ME G G+
Sbjct: 469 MIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGK 528
Query: 433 VHISEETSQFLGGSYILEEGEEV 455
VHISE T+++L Y +E+G+ +
Sbjct: 529 VHISEATAKYLDDRYEMEDGKVI 551
Score = 50.4 bits (115), Expect = 2e-05
Identities = 21/78 (26%), Positives = 43/78 (55%), Gaps = 1/78 (1%)
Query: 367 FTRMSSMIEAIQEFDRER-GEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKME 425
F M+ + +F+ +RVG + G + G++GT + +D+W + V A++M+
Sbjct: 1139 FEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMD 1198
Query: 426 SSGKPGRVHISEETSQFL 443
++G R+ +SEE+ + L
Sbjct: 1199 TTGVECRIQVSEESYRVL 1216
>AB011092-1|BAA25446.3| 1364|Homo sapiens KIAA0520 protein protein.
Length = 1364
Score = 170 bits (414), Expect = 1e-41
Identities = 115/332 (34%), Positives = 164/332 (49%), Gaps = 18/332 (5%)
Query: 57 IPIAFERAAPGTWWNPRFDSEILEGQYRSSSFRQIRLRFRFALLYILIFSISWFVYFVV- 115
+P FERA+ WW+P+FDS LE F Q + RFR+AL YI + W +YF V
Sbjct: 90 LPQLFERAS-SRWWDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVH 148
Query: 116 LGLNDVTVKWPFLCSLFA--GVLLITCIMLLV---TFTNF-YKVYTFKLSLVMAXXXXXX 169
+ + + P LC L G L T L +T+ + F L+L
Sbjct: 149 MRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALTLLVFALTLAAQFQVLTP 208
Query: 170 XXXXXXXXXXXXXXFYQAADISQSGHFTMCIEXXXXXXXXXXXXXXACVILGIIYSIVFE 229
+SQ G F+MCIE + LG+ YS++FE
Sbjct: 209 VSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFE 268
Query: 230 VLNIVLHLSEQEWQASG-------MFVRILLQLCVHIIGVHIYLMTFVRMRGTFMKVGQS 282
E + + G + R LL C+H IGVH+++M+ VR R TF+KVGQS
Sbjct: 269 TFGYHFR-DEACFPSPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQS 327
Query: 283 LLVRRQLEMEKQLKEKMIHSVMPPKLASNLMNEQVTEADTNVKTY--HNPLNSRISNPGS 340
++ + LE+EK LKE+MIHSVMP +A +LM + E++ +VK + +P N + +
Sbjct: 328 IMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQ 387
Query: 341 DIKSLFRPFNMSCMDNVSILFADIVGFTRMSS 372
FRPF M ++ VSILFADIVGFT+MS+
Sbjct: 388 KAPIAFRPFKMQQIEEVSILFADIVGFTKMSA 419
Score = 114 bits (274), Expect = 1e-24
Identities = 51/83 (61%), Positives = 66/83 (79%)
Query: 373 MIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGR 432
MI+AI++F +E+ E +NMRVGVHTGTVLCGI+G RRFKFDVWSNDV AN ME G G+
Sbjct: 480 MIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGK 539
Query: 433 VHISEETSQFLGGSYILEEGEEV 455
VHISE T+++L Y +E+G+ +
Sbjct: 540 VHISEATAKYLDDRYEMEDGKVI 562
Score = 50.0 bits (114), Expect = 3e-05
Identities = 21/78 (26%), Positives = 43/78 (55%), Gaps = 1/78 (1%)
Query: 367 FTRMSSMIEAIQEFDRER-GEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKME 425
F M+ + +F+ +RVG + G + G++GT + +D+W + V A++M+
Sbjct: 1150 FEFAKEMMRVVDDFNSNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMD 1209
Query: 426 SSGKPGRVHISEETSQFL 443
++G R+ +SEE+ + L
Sbjct: 1210 TTGVECRIQVSEESYRVL 1227
>BC111743-1|AAI11744.1| 1091|Homo sapiens adenylate cyclase 2
(brain) protein.
Length = 1091
Score = 102 bits (245), Expect = 4e-21
Identities = 45/81 (55%), Positives = 61/81 (75%)
Query: 373 MIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGR 432
M EAI++ G INMRVGVH+G VLCG++G +++++DVWS+DVT AN ME+ G PGR
Sbjct: 365 MCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGR 424
Query: 433 VHISEETSQFLGGSYILEEGE 453
VHIS T + L G+Y +EEG+
Sbjct: 425 VHISSVTLEHLNGAYKVEEGD 445
Score = 56.0 bits (129), Expect = 4e-07
Identities = 20/72 (27%), Positives = 45/72 (62%)
Query: 372 SMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPG 431
+++ + ++ +RVG++ G V+ G++G ++ ++D+W N V A++M+S+G
Sbjct: 979 ALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLD 1038
Query: 432 RVHISEETSQFL 443
++ ++EETS L
Sbjct: 1039 KIQVTEETSLVL 1050
Score = 46.4 bits (105), Expect = 3e-04
Identities = 35/132 (26%), Positives = 66/132 (50%), Gaps = 17/132 (12%)
Query: 242 WQASGMFVRILLQLCVHIIGV-HIYLMTFVRMRGTFMKVGQSLLVRRQLEMEKQLKEKMI 300
WQ + +++ +C ++ G H +LM ++ T+ + R +LE EK+ +E+++
Sbjct: 189 WQ---ILANVIIFICGNLAGAYHKHLMELA-LQQTYQDTCNCIKSRIKLEFEKRQQERLL 244
Query: 301 HSVMPPKLASNLMNEQVTEADTNVKTYHNPLNSRISNPGSDIKSLFRPFNMSCMDNVSIL 360
S++P +A + E + + P ++ N + F + NVSIL
Sbjct: 245 LSLLPAHIAMEMKAEII-------QRLQGPKAGQMENTNN-----FHNLYVKRHTNVSIL 292
Query: 361 FADIVGFTRMSS 372
+ADIVGFTR++S
Sbjct: 293 YADIVGFTRLAS 304
>AF410885-1|AAP97285.1| 1091|Homo sapiens adenylyl cyclase type II
protein.
Length = 1091
Score = 102 bits (245), Expect = 4e-21
Identities = 45/81 (55%), Positives = 61/81 (75%)
Query: 373 MIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGR 432
M EAI++ G INMRVGVH+G VLCG++G +++++DVWS+DVT AN ME+ G PGR
Sbjct: 365 MCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGR 424
Query: 433 VHISEETSQFLGGSYILEEGE 453
VHIS T + L G+Y +EEG+
Sbjct: 425 VHISSVTLEHLNGAYKVEEGD 445
Score = 56.0 bits (129), Expect = 4e-07
Identities = 20/72 (27%), Positives = 45/72 (62%)
Query: 372 SMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPG 431
+++ + ++ +RVG++ G V+ G++G ++ ++D+W N V A++M+S+G
Sbjct: 979 ALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLD 1038
Query: 432 RVHISEETSQFL 443
++ ++EETS L
Sbjct: 1039 KIQVTEETSLVL 1050
Score = 41.9 bits (94), Expect = 0.007
Identities = 31/110 (28%), Positives = 55/110 (50%), Gaps = 13/110 (11%)
Query: 263 HIYLMTFVRMRGTFMKVGQSLLVRRQLEMEKQLKEKMIHSVMPPKLASNLMNEQVTEADT 322
H +LM ++ T+ + R +LE EK+ +E+++ S++P +A + E +
Sbjct: 208 HKHLMELA-LQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEII----- 261
Query: 323 NVKTYHNPLNSRISNPGSDIKSLFRPFNMSCMDNVSILFADIVGFTRMSS 372
+ P ++ N + F + NVSIL+ADIVGFTR++S
Sbjct: 262 --QRLQGPKAGQMENTNN-----FHNLYVKRHTNVSILYADIVGFTRLAS 304
>AB028983-1|BAA83012.1| 887|Homo sapiens KIAA1060 protein protein.
Length = 887
Score = 102 bits (245), Expect = 4e-21
Identities = 45/81 (55%), Positives = 61/81 (75%)
Query: 373 MIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGR 432
M EAI++ G INMRVGVH+G VLCG++G +++++DVWS+DVT AN ME+ G PGR
Sbjct: 161 MCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGR 220
Query: 433 VHISEETSQFLGGSYILEEGE 453
VHIS T + L G+Y +EEG+
Sbjct: 221 VHISSVTLEHLNGAYKVEEGD 241
Score = 56.0 bits (129), Expect = 4e-07
Identities = 20/72 (27%), Positives = 45/72 (62%)
Query: 372 SMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPG 431
+++ + ++ +RVG++ G V+ G++G ++ ++D+W N V A++M+S+G
Sbjct: 775 ALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLD 834
Query: 432 RVHISEETSQFL 443
++ ++EETS L
Sbjct: 835 KIQVTEETSLVL 846
Score = 41.9 bits (94), Expect = 0.007
Identities = 31/110 (28%), Positives = 55/110 (50%), Gaps = 13/110 (11%)
Query: 263 HIYLMTFVRMRGTFMKVGQSLLVRRQLEMEKQLKEKMIHSVMPPKLASNLMNEQVTEADT 322
H +LM ++ T+ + R +LE EK+ +E+++ S++P +A + E +
Sbjct: 4 HKHLMELA-LQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEII----- 57
Query: 323 NVKTYHNPLNSRISNPGSDIKSLFRPFNMSCMDNVSILFADIVGFTRMSS 372
+ P ++ N + F + NVSIL+ADIVGFTR++S
Sbjct: 58 --QRLQGPKAGQMENTNN-----FHNLYVKRHTNVSILYADIVGFTRLAS 100
>BC064923-1|AAH64923.1| 1168|Homo sapiens ADCY6 protein protein.
Length = 1168
Score = 99 bits (238), Expect = 3e-20
Identities = 43/80 (53%), Positives = 57/80 (71%)
Query: 373 MIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGR 432
MIEAI G +NMRVG+H+G V CG++G R+++FDVWSNDVT AN ME+ G+ GR
Sbjct: 454 MIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGR 513
Query: 433 VHISEETSQFLGGSYILEEG 452
+HI+ T Q+L G Y +E G
Sbjct: 514 IHITRATLQYLNGDYEVEPG 533
Score = 57.6 bits (133), Expect = 1e-07
Identities = 35/140 (25%), Positives = 65/140 (46%), Gaps = 3/140 (2%)
Query: 312 LMNEQVTEADTNVKTYHNPLNSRISNPGSDIKSLFRPFNMSCMDNVSILFADIVGFTRMS 371
L+NE + + D + +I GS + N S D V + M
Sbjct: 1007 LLNEIIADFDEIISEERFRQLEKIKTIGSTYMAA-SGLNASTYDQVGRSHITALADYAMR 1065
Query: 372 SMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPG 431
M E ++ + M++G++ G V+ G++G R+ ++D+W N V +++M+S+G P
Sbjct: 1066 LM-EQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPD 1124
Query: 432 RVHISEETSQFLGG-SYILE 450
R+ ++ + Q L Y LE
Sbjct: 1125 RIQVTTDLYQVLAAKGYQLE 1144
Score = 46.8 bits (106), Expect = 3e-04
Identities = 45/162 (27%), Positives = 74/162 (45%), Gaps = 24/162 (14%)
Query: 216 ACVILGIIYSIVFEVLNIVLHLSEQE-WQASGMFVRILLQLCVHIIGVHIYLMTFVRMRG 274
A V+ G+ S + +L L+ + W+ G +LL LC ++IG+ + V R
Sbjct: 259 AAVLSGLGLSTLHLILAWQLNRGDAFLWKQLG--ANVLLFLCTNVIGICTHYPAEVSQRQ 316
Query: 275 TFMKVGQSLLVRRQLEMEKQLKEKMIHSVMPPKLASNLMNEQVTEADTNVKTYHNPLNSR 334
F + + R L+ E + +E+++ SV+P +A + + D N K
Sbjct: 317 AFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEM------KEDINTKK-------- 362
Query: 335 ISNPGSDIKSLFRPFNMSCMDNVSILFADIVGFTRMSSMIEA 376
D+ +F + DNVSILFADI GFT ++S A
Sbjct: 363 -----EDM--MFHKIYIQKHDNVSILFADIEGFTSLASQCTA 397
>AF250226-1|AAF82478.1| 1168|Homo sapiens adenylyl cyclase type VI
protein.
Length = 1168
Score = 99 bits (238), Expect = 3e-20
Identities = 43/80 (53%), Positives = 57/80 (71%)
Query: 373 MIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGR 432
MIEAI G +NMRVG+H+G V CG++G R+++FDVWSNDVT AN ME+ G+ GR
Sbjct: 454 MIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGR 513
Query: 433 VHISEETSQFLGGSYILEEG 452
+HI+ T Q+L G Y +E G
Sbjct: 514 IHITRATLQYLNGDYEVEPG 533
Score = 57.6 bits (133), Expect = 1e-07
Identities = 35/140 (25%), Positives = 65/140 (46%), Gaps = 3/140 (2%)
Query: 312 LMNEQVTEADTNVKTYHNPLNSRISNPGSDIKSLFRPFNMSCMDNVSILFADIVGFTRMS 371
L+NE + + D + +I GS + N S D V + M
Sbjct: 1007 LLNEIIADFDEIISEERFRQLEKIKTIGSTYMAA-SGLNASTYDQVGRSHITALADYAMR 1065
Query: 372 SMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPG 431
M E ++ + M++G++ G V+ G++G R+ ++D+W N V +++M+S+G P
Sbjct: 1066 LM-EQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPD 1124
Query: 432 RVHISEETSQFLGG-SYILE 450
R+ ++ + Q L Y LE
Sbjct: 1125 RIQVTTDLYQVLAAKGYQLE 1144
Score = 46.8 bits (106), Expect = 3e-04
Identities = 45/162 (27%), Positives = 74/162 (45%), Gaps = 24/162 (14%)
Query: 216 ACVILGIIYSIVFEVLNIVLHLSEQE-WQASGMFVRILLQLCVHIIGVHIYLMTFVRMRG 274
A V+ G+ S + +L L+ + W+ G +LL LC ++IG+ + V R
Sbjct: 259 AAVLSGLGLSTLHLILAWQLNRGDAFLWKQLG--ANVLLFLCTNVIGICTHYPAEVSQRQ 316
Query: 275 TFMKVGQSLLVRRQLEMEKQLKEKMIHSVMPPKLASNLMNEQVTEADTNVKTYHNPLNSR 334
F + + R L+ E + +E+++ SV+P +A + + D N K
Sbjct: 317 AFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEM------KEDINTKK-------- 362
Query: 335 ISNPGSDIKSLFRPFNMSCMDNVSILFADIVGFTRMSSMIEA 376
D+ +F + DNVSILFADI GFT ++S A
Sbjct: 363 -----EDM--MFHKIYIQKHDNVSILFADIEGFTSLASQCTA 397
>AB007882-1|BAA24852.2| 1160|Homo sapiens KIAA0422 protein.
Length = 1160
Score = 99 bits (238), Expect = 3e-20
Identities = 43/80 (53%), Positives = 57/80 (71%)
Query: 373 MIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGR 432
MIEAI G +NMRVG+H+G V CG++G R+++FDVWSNDVT AN ME+ G+ GR
Sbjct: 499 MIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGR 558
Query: 433 VHISEETSQFLGGSYILEEG 452
+HI+ T Q+L G Y +E G
Sbjct: 559 IHITRATLQYLNGDYEVEPG 578
Score = 57.6 bits (133), Expect = 1e-07
Identities = 35/140 (25%), Positives = 65/140 (46%), Gaps = 3/140 (2%)
Query: 312 LMNEQVTEADTNVKTYHNPLNSRISNPGSDIKSLFRPFNMSCMDNVSILFADIVGFTRMS 371
L+NE + + D + +I GS + N S D V + M
Sbjct: 999 LLNEIIADFDEIISEERFRQLEKIKTIGSTYMAA-SGLNASTYDQVGRSHITALADYAMR 1057
Query: 372 SMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPG 431
M E ++ + M++G++ G V+ G++G R+ ++D+W N V +++M+S+G P
Sbjct: 1058 LM-EQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPD 1116
Query: 432 RVHISEETSQFLGG-SYILE 450
R+ ++ + Q L Y LE
Sbjct: 1117 RIQVTTDLYQVLAAKGYQLE 1136
Score = 46.8 bits (106), Expect = 3e-04
Identities = 45/162 (27%), Positives = 74/162 (45%), Gaps = 24/162 (14%)
Query: 216 ACVILGIIYSIVFEVLNIVLHLSEQE-WQASGMFVRILLQLCVHIIGVHIYLMTFVRMRG 274
A V+ G+ S + +L L+ + W+ G +LL LC ++IG+ + V R
Sbjct: 304 AAVLSGLGLSTLHLILAWQLNRGDAFLWKQLG--ANVLLFLCTNVIGICTHYPAEVSQRQ 361
Query: 275 TFMKVGQSLLVRRQLEMEKQLKEKMIHSVMPPKLASNLMNEQVTEADTNVKTYHNPLNSR 334
F + + R L+ E + +E+++ SV+P +A + + D N K
Sbjct: 362 AFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEM------KEDINTKK-------- 407
Query: 335 ISNPGSDIKSLFRPFNMSCMDNVSILFADIVGFTRMSSMIEA 376
D+ +F + DNVSILFADI GFT ++S A
Sbjct: 408 -----EDM--MFHKIYIQKHDNVSILFADIEGFTSLASQCTA 442
>AF497517-1|AAM94374.1| 894|Homo sapiens adenylate cyclase type V
protein.
Length = 894
Score = 99.5 bits (237), Expect = 4e-20
Identities = 43/80 (53%), Positives = 57/80 (71%)
Query: 373 MIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGR 432
MIEAI G +NMRVG+H+G V CG++G R+++FDVWSNDVT AN ME+ GK GR
Sbjct: 177 MIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGR 236
Query: 433 VHISEETSQFLGGSYILEEG 452
+HI++ T +L G Y +E G
Sbjct: 237 IHITKATLNYLNGDYEVEPG 256
Score = 56.8 bits (131), Expect = 2e-07
Identities = 22/79 (27%), Positives = 48/79 (60%), Gaps = 1/79 (1%)
Query: 373 MIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGR 432
+++ ++ + M++G++ G V+ G++G R+ ++D+W N V A++M+S+G P R
Sbjct: 791 LMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDR 850
Query: 433 VHISEETSQFL-GGSYILE 450
+ ++ + Q L +Y LE
Sbjct: 851 IQVTTDMYQVLAANTYQLE 869
Score = 46.0 bits (104), Expect = 5e-04
Identities = 37/126 (29%), Positives = 59/126 (46%), Gaps = 21/126 (16%)
Query: 251 ILLQLCVHIIGVHIYLMTFVRMRGTFMKVGQSLLVRRQLEMEKQLKEKMIHSVMPPKLAS 310
+L+ C +I+GV + V R F + + + R + E Q +E+++ SV+P +A
Sbjct: 16 VLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAM 75
Query: 311 NLMNEQVTEADTNVKTYHNPLNSRISNPGSDIKSLFRPFNMSCMDNVSILFADIVGFTRM 370
+ +AD N K D+ +F + DNVSILFADI GFT +
Sbjct: 76 EM------KADINAKQ-------------EDM--MFHKIYIQKHDNVSILFADIEGFTSL 114
Query: 371 SSMIEA 376
+S A
Sbjct: 115 ASQCTA 120
>D25538-1|BAA05021.2| 1088|Homo sapiens KIAA0037 protein.
Length = 1088
Score = 99.1 bits (236), Expect = 5e-20
Identities = 41/80 (51%), Positives = 62/80 (77%)
Query: 373 MIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGR 432
M +AI++ G INMRVG+H+G VLCG++G R++++DVWS+DV+ AN+ME++G PGR
Sbjct: 362 MCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGR 421
Query: 433 VHISEETSQFLGGSYILEEG 452
VHI+E T + L +Y +E+G
Sbjct: 422 VHITEATLKHLDKAYEVEDG 441
Score = 64.5 bits (150), Expect = 1e-09
Identities = 24/74 (32%), Positives = 47/74 (63%)
Query: 372 SMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPG 431
+++ + +R +RVG++ G V+ G++G R+ ++D+W N V A++MES+G+ G
Sbjct: 978 ALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELG 1037
Query: 432 RVHISEETSQFLGG 445
++ ++EET L G
Sbjct: 1038 KIQVTEETCTILQG 1051
Score = 41.5 bits (93), Expect = 0.010
Identities = 36/127 (28%), Positives = 65/127 (51%), Gaps = 14/127 (11%)
Query: 247 MFVRILLQLCVHIIGV-HIYLMTFVRMRGTFMKVGQSLLVRRQLEMEKQLKEKMIHSVMP 305
+ ++ LC ++ G H + M R F + + +RR+L +EK+ +E ++ SV+P
Sbjct: 188 LLANAVIFLCGNLTGAFHKHQMQDAS-RDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLP 246
Query: 306 PKLASNLMNEQVTEADTNVKTYHNPLNSRISNPGSDIKSLFRPFNMSCMDNVSILFADIV 365
++ M + E +K + R P ++ SL+ + NVSIL+ADIV
Sbjct: 247 AHISMG-MKLAIIE---RLKEH----GDRRCMPDNNFHSLY----VKRHQNVSILYADIV 294
Query: 366 GFTRMSS 372
GFT+++S
Sbjct: 295 GFTQLAS 301
>BC126271-1|AAI26272.1| 1080|Homo sapiens adenylate cyclase 7
protein.
Length = 1080
Score = 99.1 bits (236), Expect = 5e-20
Identities = 41/80 (51%), Positives = 62/80 (77%)
Query: 373 MIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGR 432
M +AI++ G INMRVG+H+G VLCG++G R++++DVWS+DV+ AN+ME++G PGR
Sbjct: 354 MCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGR 413
Query: 433 VHISEETSQFLGGSYILEEG 452
VHI+E T + L +Y +E+G
Sbjct: 414 VHITEATLKHLDKAYEVEDG 433
Score = 64.5 bits (150), Expect = 1e-09
Identities = 24/74 (32%), Positives = 47/74 (63%)
Query: 372 SMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPG 431
+++ + +R +RVG++ G V+ G++G R+ ++D+W N V A++MES+G+ G
Sbjct: 970 ALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELG 1029
Query: 432 RVHISEETSQFLGG 445
++ ++EET L G
Sbjct: 1030 KIQVTEETCTILQG 1043
Score = 41.5 bits (93), Expect = 0.010
Identities = 36/127 (28%), Positives = 65/127 (51%), Gaps = 14/127 (11%)
Query: 247 MFVRILLQLCVHIIGV-HIYLMTFVRMRGTFMKVGQSLLVRRQLEMEKQLKEKMIHSVMP 305
+ ++ LC ++ G H + M R F + + +RR+L +EK+ +E ++ SV+P
Sbjct: 180 LLANAVIFLCGNLTGAFHKHQMQDAS-RDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLP 238
Query: 306 PKLASNLMNEQVTEADTNVKTYHNPLNSRISNPGSDIKSLFRPFNMSCMDNVSILFADIV 365
++ M + E +K + R P ++ SL+ + NVSIL+ADIV
Sbjct: 239 AHISMG-MKLAIIE---RLKEH----GDRRCMPDNNFHSLY----VKRHQNVSILYADIV 286
Query: 366 GFTRMSS 372
GFT+++S
Sbjct: 287 GFTQLAS 293
>BC126235-1|AAI26236.1| 1144|Homo sapiens adenylate cyclase 3
protein.
Length = 1144
Score = 98.7 bits (235), Expect = 6e-20
Identities = 44/82 (53%), Positives = 60/82 (73%)
Query: 372 SMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPG 431
+M+EAI + G++MRVGVHTGTVL G++G +R+++DVWS DVT ANKME+ G PG
Sbjct: 393 AMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPG 452
Query: 432 RVHISEETSQFLGGSYILEEGE 453
RVHIS+ T L G + +E G+
Sbjct: 453 RVHISQSTMDCLKGEFDVEPGD 474
Score = 59.3 bits (137), Expect = 5e-08
Identities = 46/165 (27%), Positives = 78/165 (47%), Gaps = 24/165 (14%)
Query: 218 VILGIIYSIVFEVLNIVLHLSEQEWQASGM------FVRILLQLCVHIIGVHIYLMTFVR 271
VI+ ++ +V ++ V +Q+ + GM + L LC +G+ Y M +
Sbjct: 191 VIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVFLYLCAIAVGIMSYYMADRK 250
Query: 272 MRGTFMKVGQSLLVRRQLEMEKQLKEKMIHSVMPPKLASNLMNEQVTEADTNVKTYHNPL 331
R F++ QSL V+ LE + Q +E ++ S++P +A ++ + + D + K
Sbjct: 251 HRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDM--KKDESQKD----- 303
Query: 332 NSRISNPGSDIKSLFRPFNMSCMDNVSILFADIVGFTRMSSMIEA 376
+ F M +NVSILFADIVGFT++SS A
Sbjct: 304 -----------QQQFNTMYMYRHENVSILFADIVGFTQLSSACSA 337
Score = 59.3 bits (137), Expect = 5e-08
Identities = 34/124 (27%), Positives = 60/124 (48%), Gaps = 8/124 (6%)
Query: 362 ADIVGFTRMSSMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFA 421
AD+ F +M + + + + +R+G++ G VL G++G R+ +D+W N V A
Sbjct: 1014 ADLADFAL--AMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVA 1071
Query: 422 NKMESSGKPGRVHISEETSQFLG--GSYILEEGEEVFGHK----TYFIEGRQVFCPYDRE 475
++MES+G G + + EET L G + G K T+F++GR +
Sbjct: 1072 SRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDKLATFPNG 1131
Query: 476 QCLT 479
+T
Sbjct: 1132 PSVT 1135
>AF033861-1|AAD13403.1| 1144|Homo sapiens type III adenylyl cyclase
protein.
Length = 1144
Score = 98.7 bits (235), Expect = 6e-20
Identities = 44/82 (53%), Positives = 60/82 (73%)
Query: 372 SMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPG 431
+M+EAI + G++MRVGVHTGTVL G++G +R+++DVWS DVT ANKME+ G PG
Sbjct: 393 AMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPG 452
Query: 432 RVHISEETSQFLGGSYILEEGE 453
RVHIS+ T L G + +E G+
Sbjct: 453 RVHISQSTMDCLKGEFDVEPGD 474
Score = 59.3 bits (137), Expect = 5e-08
Identities = 46/165 (27%), Positives = 78/165 (47%), Gaps = 24/165 (14%)
Query: 218 VILGIIYSIVFEVLNIVLHLSEQEWQASGM------FVRILLQLCVHIIGVHIYLMTFVR 271
VI+ ++ +V ++ V +Q+ + GM + L LC +G+ Y M +
Sbjct: 191 VIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVFLYLCAIAVGIMSYYMADRK 250
Query: 272 MRGTFMKVGQSLLVRRQLEMEKQLKEKMIHSVMPPKLASNLMNEQVTEADTNVKTYHNPL 331
R F++ QSL V+ LE + Q +E ++ S++P +A ++ + + D + K
Sbjct: 251 HRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDM--KKDESQKD----- 303
Query: 332 NSRISNPGSDIKSLFRPFNMSCMDNVSILFADIVGFTRMSSMIEA 376
+ F M +NVSILFADIVGFT++SS A
Sbjct: 304 -----------QQQFNTMYMYRHENVSILFADIVGFTQLSSACSA 337
Score = 59.3 bits (137), Expect = 5e-08
Identities = 34/124 (27%), Positives = 60/124 (48%), Gaps = 8/124 (6%)
Query: 362 ADIVGFTRMSSMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFA 421
AD+ F +M + + + + +R+G++ G VL G++G R+ +D+W N V A
Sbjct: 1014 ADLADFAL--AMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVA 1071
Query: 422 NKMESSGKPGRVHISEETSQFLG--GSYILEEGEEVFGHK----TYFIEGRQVFCPYDRE 475
++MES+G G + + EET L G + G K T+F++GR +
Sbjct: 1072 SRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDKLATFPNG 1131
Query: 476 QCLT 479
+T
Sbjct: 1132 PSVT 1135
>AC012073-2|AAY14787.1| 1144|Homo sapiens unknown protein.
Length = 1144
Score = 98.7 bits (235), Expect = 6e-20
Identities = 44/82 (53%), Positives = 60/82 (73%)
Query: 372 SMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPG 431
+M+EAI + G++MRVGVHTGTVL G++G +R+++DVWS DVT ANKME+ G PG
Sbjct: 393 AMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPG 452
Query: 432 RVHISEETSQFLGGSYILEEGE 453
RVHIS+ T L G + +E G+
Sbjct: 453 RVHISQSTMDCLKGEFDVEPGD 474
Score = 59.3 bits (137), Expect = 5e-08
Identities = 46/165 (27%), Positives = 78/165 (47%), Gaps = 24/165 (14%)
Query: 218 VILGIIYSIVFEVLNIVLHLSEQEWQASGM------FVRILLQLCVHIIGVHIYLMTFVR 271
VI+ ++ +V ++ V +Q+ + GM + L LC +G+ Y M +
Sbjct: 191 VIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVFLYLCAIAVGIMSYYMADRK 250
Query: 272 MRGTFMKVGQSLLVRRQLEMEKQLKEKMIHSVMPPKLASNLMNEQVTEADTNVKTYHNPL 331
R F++ QSL V+ LE + Q +E ++ S++P +A ++ + + D + K
Sbjct: 251 HRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDM--KKDESQKD----- 303
Query: 332 NSRISNPGSDIKSLFRPFNMSCMDNVSILFADIVGFTRMSSMIEA 376
+ F M +NVSILFADIVGFT++SS A
Sbjct: 304 -----------QQQFNTMYMYRHENVSILFADIVGFTQLSSACSA 337
Score = 59.3 bits (137), Expect = 5e-08
Identities = 34/124 (27%), Positives = 60/124 (48%), Gaps = 8/124 (6%)
Query: 362 ADIVGFTRMSSMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFA 421
AD+ F +M + + + + +R+G++ G VL G++G R+ +D+W N V A
Sbjct: 1014 ADLADFAL--AMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVA 1071
Query: 422 NKMESSGKPGRVHISEETSQFLG--GSYILEEGEEVFGHK----TYFIEGRQVFCPYDRE 475
++MES+G G + + EET L G + G K T+F++GR +
Sbjct: 1072 SRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDKLATFPNG 1131
Query: 476 QCLT 479
+T
Sbjct: 1132 PSVT 1135
>AB011083-1|BAA25437.1| 933|Homo sapiens KIAA0511 protein protein.
Length = 933
Score = 98.7 bits (235), Expect = 6e-20
Identities = 44/82 (53%), Positives = 60/82 (73%)
Query: 372 SMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPG 431
+M+EAI + G++MRVGVHTGTVL G++G +R+++DVWS DVT ANKME+ G PG
Sbjct: 182 AMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPG 241
Query: 432 RVHISEETSQFLGGSYILEEGE 453
RVHIS+ T L G + +E G+
Sbjct: 242 RVHISQSTMDCLKGEFDVEPGD 263
Score = 59.3 bits (137), Expect = 5e-08
Identities = 34/124 (27%), Positives = 60/124 (48%), Gaps = 8/124 (6%)
Query: 362 ADIVGFTRMSSMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFA 421
AD+ F +M + + + + +R+G++ G VL G++G R+ +D+W N V A
Sbjct: 803 ADLADFAL--AMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVA 860
Query: 422 NKMESSGKPGRVHISEETSQFLG--GSYILEEGEEVFGHK----TYFIEGRQVFCPYDRE 475
++MES+G G + + EET L G + G K T+F++GR +
Sbjct: 861 SRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDKLATFPNG 920
Query: 476 QCLT 479
+T
Sbjct: 921 PSVT 924
Score = 56.0 bits (129), Expect = 4e-07
Identities = 39/130 (30%), Positives = 63/130 (48%), Gaps = 18/130 (13%)
Query: 247 MFVRILLQLCVHIIGVHIYLMTFVRMRGTFMKVGQSLLVRRQLEMEKQLKEKMIHSVMPP 306
+ + L LC +G+ Y M + R F++ QSL V+ LE + Q +E ++ S++P
Sbjct: 15 ILANVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPK 74
Query: 307 KLASNLMNEQVTEADTNVKTYHNPLNSRISNPGSDIKSLFRPFNMSCMDNVSILFADIVG 366
+A ++ + + D + K + F M +NVSILFADIVG
Sbjct: 75 HVADEMLKDM--KKDESQKD----------------QQQFNTMYMYRHENVSILFADIVG 116
Query: 367 FTRMSSMIEA 376
FT++SS A
Sbjct: 117 FTQLSSACSA 126
>BC117475-1|AAI17476.1| 1077|Homo sapiens adenylate cyclase 4
protein.
Length = 1077
Score = 97.1 bits (231), Expect = 2e-19
Identities = 45/101 (44%), Positives = 66/101 (65%), Gaps = 2/101 (1%)
Query: 353 CMDNVSILFAD-IVGFTRMS-SMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFK 410
C+ + + D + RM M AI++ G INMRVGVH+G+VLCG++G ++++
Sbjct: 326 CVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGVIGLQKWQ 385
Query: 411 FDVWSNDVTFANKMESSGKPGRVHISEETSQFLGGSYILEE 451
+DVWS+DVT AN ME+ G PGRVHI+ T L G+Y +E+
Sbjct: 386 YDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVED 426
Score = 58.4 bits (135), Expect = 8e-08
Identities = 28/94 (29%), Positives = 52/94 (55%), Gaps = 5/94 (5%)
Query: 390 MRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGRVHISEETSQFLGGSYIL 449
+RVG++ G V+ G++G ++ ++D+W N V A++MES+G G++ ++EET+ L
Sbjct: 983 LRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSL--- 1039
Query: 450 EEGEEVFGHKTYFIEGRQVFCPYDREQCLTPSNP 483
G + ++G+ C Y LT + P
Sbjct: 1040 --GYTCYSRGVIKVKGKGQLCTYFLNTDLTRTGP 1071
Score = 49.2 bits (112), Expect = 5e-05
Identities = 35/121 (28%), Positives = 59/121 (48%), Gaps = 12/121 (9%)
Query: 252 LLQLCVHIIGVHIYLMTFVRMRGTFMKVGQSLLVRRQLEMEKQLKEKMIHSVMPPKLASN 311
+L LC ++ GV+ + +R TF + SL RR+L+ EK+ +E ++ S++P LA
Sbjct: 179 VLFLCGNVAGVYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLARE 238
Query: 312 LMNEQVTEADTNVKTYHNPLNSRISNPGSDIKSLFRPFNMSCMDNVSILFADIVGFTRMS 371
+ E + + N+ F + VS+L+ADIVGFTR++
Sbjct: 239 MKAEIMARLQAGQGSRPESTNN------------FHSLYVKRHQGVSVLYADIVGFTRLA 286
Query: 372 S 372
S
Sbjct: 287 S 287
>BC117473-1|AAI17474.1| 1077|Homo sapiens adenylate cyclase 4
protein.
Length = 1077
Score = 97.1 bits (231), Expect = 2e-19
Identities = 45/101 (44%), Positives = 66/101 (65%), Gaps = 2/101 (1%)
Query: 353 CMDNVSILFAD-IVGFTRMS-SMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFK 410
C+ + + D + RM M AI++ G INMRVGVH+G+VLCG++G ++++
Sbjct: 326 CVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGVIGLQKWQ 385
Query: 411 FDVWSNDVTFANKMESSGKPGRVHISEETSQFLGGSYILEE 451
+DVWS+DVT AN ME+ G PGRVHI+ T L G+Y +E+
Sbjct: 386 YDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVED 426
Score = 58.4 bits (135), Expect = 8e-08
Identities = 28/94 (29%), Positives = 52/94 (55%), Gaps = 5/94 (5%)
Query: 390 MRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGRVHISEETSQFLGGSYIL 449
+RVG++ G V+ G++G ++ ++D+W N V A++MES+G G++ ++EET+ L
Sbjct: 983 LRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSL--- 1039
Query: 450 EEGEEVFGHKTYFIEGRQVFCPYDREQCLTPSNP 483
G + ++G+ C Y LT + P
Sbjct: 1040 --GYTCYSRGVIKVKGKGQLCTYFLNTDLTRTGP 1071
Score = 49.2 bits (112), Expect = 5e-05
Identities = 35/121 (28%), Positives = 59/121 (48%), Gaps = 12/121 (9%)
Query: 252 LLQLCVHIIGVHIYLMTFVRMRGTFMKVGQSLLVRRQLEMEKQLKEKMIHSVMPPKLASN 311
+L LC ++ GV+ + +R TF + SL RR+L+ EK+ +E ++ S++P LA
Sbjct: 179 VLFLCGNVAGVYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLARE 238
Query: 312 LMNEQVTEADTNVKTYHNPLNSRISNPGSDIKSLFRPFNMSCMDNVSILFADIVGFTRMS 371
+ E + + N+ F + VS+L+ADIVGFTR++
Sbjct: 239 MKAEIMARLQAGQGSRPESTNN------------FHSLYVKRHQGVSVLYADIVGFTRLA 286
Query: 372 S 372
S
Sbjct: 287 S 287
>AF497516-1|AAM94373.1| 1077|Homo sapiens adenylate cyclase type IV
protein.
Length = 1077
Score = 97.1 bits (231), Expect = 2e-19
Identities = 45/101 (44%), Positives = 66/101 (65%), Gaps = 2/101 (1%)
Query: 353 CMDNVSILFAD-IVGFTRMS-SMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFK 410
C+ + + D + RM M AI++ G INMRVGVH+G+VLCG++G ++++
Sbjct: 326 CVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGVIGLQKWQ 385
Query: 411 FDVWSNDVTFANKMESSGKPGRVHISEETSQFLGGSYILEE 451
+DVWS+DVT AN ME+ G PGRVHI+ T L G+Y +E+
Sbjct: 386 YDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVED 426
Score = 58.4 bits (135), Expect = 8e-08
Identities = 28/94 (29%), Positives = 52/94 (55%), Gaps = 5/94 (5%)
Query: 390 MRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGRVHISEETSQFLGGSYIL 449
+RVG++ G V+ G++G ++ ++D+W N V A++MES+G G++ ++EET+ L
Sbjct: 983 LRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSL--- 1039
Query: 450 EEGEEVFGHKTYFIEGRQVFCPYDREQCLTPSNP 483
G + ++G+ C Y LT + P
Sbjct: 1040 --GYTCYSRGVIKVKGKGQLCTYFLNTDLTRTGP 1071
Score = 49.2 bits (112), Expect = 5e-05
Identities = 35/121 (28%), Positives = 59/121 (48%), Gaps = 12/121 (9%)
Query: 252 LLQLCVHIIGVHIYLMTFVRMRGTFMKVGQSLLVRRQLEMEKQLKEKMIHSVMPPKLASN 311
+L LC ++ GV+ + +R TF + SL RR+L+ EK+ +E ++ S++P LA
Sbjct: 179 VLFLCGNVAGVYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLARE 238
Query: 312 LMNEQVTEADTNVKTYHNPLNSRISNPGSDIKSLFRPFNMSCMDNVSILFADIVGFTRMS 371
+ E + + N+ F + VS+L+ADIVGFTR++
Sbjct: 239 MKAEIMARLQAGQGSRPESTNN------------FHSLYVKRHQGVSVLYADIVGFTRLA 286
Query: 372 S 372
S
Sbjct: 287 S 287
>DQ104739-1|AAZ13596.1| 1120|Homo sapiens brain adenylate cyclase 8
protein.
Length = 1120
Score = 96.7 bits (230), Expect = 2e-19
Identities = 42/81 (51%), Positives = 58/81 (71%)
Query: 372 SMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPG 431
SMI+ I+ ++MR+G+H+G+VLCG++G R+++FDVWS DV ANK+ES G PG
Sbjct: 488 SMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPG 547
Query: 432 RVHISEETSQFLGGSYILEEG 452
R+HISE T L G Y +EEG
Sbjct: 548 RIHISEATLDCLNGDYNVEEG 568
Score = 65.7 bits (153), Expect = 5e-10
Identities = 32/105 (30%), Positives = 58/105 (55%), Gaps = 10/105 (9%)
Query: 372 SMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPG 431
++ E+IQE ++ +R+G+ G+V+ G++G ++ ++D+W V A++M+S+G G
Sbjct: 938 ALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSG 997
Query: 432 RVHISEETSQFL----------GGSYILEEGEEVFGHKTYFIEGR 466
R+ + EET L G Y+ E+ KTYF+ GR
Sbjct: 998 RIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGR 1042
Score = 50.0 bits (114), Expect = 3e-05
Identities = 38/135 (28%), Positives = 68/135 (50%), Gaps = 19/135 (14%)
Query: 252 LLQLCVHIIGVHIYLMTFVRMRGTFMKVGQSLLVRRQLEMEKQLKEKMIHSVMPPKLASN 311
+L +C++ G+ I ++ R F++ + + R +LE E Q +E+++ SV+P +
Sbjct: 326 VLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLE 385
Query: 312 LMNEQVTEADTNVKTYHNPLNSRISNPGSDIKSLFRPFNMSCMDNVSILFADIVGFTRMS 371
++N+ TNV+ H ++ F + +NVSILFAD+ GFT +S
Sbjct: 386 MINDM-----TNVEDGH-------------LQHQFHRIYIHRYENVSILFADVKGFTNLS 427
Query: 372 SMIEAIQEFDRERGE 386
+ + A QE R E
Sbjct: 428 ATLSA-QELVRMLNE 441
>Z35309-1|CAA84552.1| 1251|Homo sapiens adenylyl cyclase protein.
Length = 1251
Score = 95.1 bits (226), Expect = 8e-19
Identities = 41/81 (50%), Positives = 58/81 (71%)
Query: 372 SMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPG 431
SMI+ I+ ++MR+G+H+G+VLCG++G R+++FDVWS DV ANK+ES G PG
Sbjct: 488 SMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPG 547
Query: 432 RVHISEETSQFLGGSYILEEG 452
R+HIS+ T L G Y +EEG
Sbjct: 548 RIHISKATLDCLNGDYNVEEG 568
Score = 65.7 bits (153), Expect = 5e-10
Identities = 32/105 (30%), Positives = 58/105 (55%), Gaps = 10/105 (9%)
Query: 372 SMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPG 431
++ E+IQE ++ +R+G+ G+V+ G++G ++ ++D+W V A++M+S+G G
Sbjct: 1069 ALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSG 1128
Query: 432 RVHISEETSQFL----------GGSYILEEGEEVFGHKTYFIEGR 466
R+ + EET L G Y+ E+ KTYF+ GR
Sbjct: 1129 RIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGR 1173
Score = 50.4 bits (115), Expect = 2e-05
Identities = 38/135 (28%), Positives = 68/135 (50%), Gaps = 19/135 (14%)
Query: 252 LLQLCVHIIGVHIYLMTFVRMRGTFMKVGQSLLVRRQLEMEKQLKEKMIHSVMPPKLASN 311
+L +C++ G+ I ++ R F++ + + R +LE E Q +E+++ SV+P +
Sbjct: 326 VLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLE 385
Query: 312 LMNEQVTEADTNVKTYHNPLNSRISNPGSDIKSLFRPFNMSCMDNVSILFADIVGFTRMS 371
++N+ TNV+ H ++ F + +NVSILFAD+ GFT +S
Sbjct: 386 MINDM-----TNVEDEH-------------LQHQFHRIYIHRYENVSILFADVKGFTNLS 427
Query: 372 SMIEAIQEFDRERGE 386
+ + A QE R E
Sbjct: 428 TTLSA-QELVRMLNE 441
>L05500-1|AAA02907.1| 839|Homo sapiens adenylyl cyclase protein.
Length = 839
Score = 94.7 bits (225), Expect = 1e-18
Identities = 43/87 (49%), Positives = 60/87 (68%), Gaps = 3/87 (3%)
Query: 373 MIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGR 432
MI+ I +NMRVG+HTG VLCG++G R++++DVWSNDVT AN ME++G PG+
Sbjct: 98 MIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGK 157
Query: 433 VHISEETSQFLGGSYILEEGEEVFGHK 459
VHI++ T L G Y +E G +GH+
Sbjct: 158 VHITKTTLACLNGDYEVEPG---YGHE 181
Score = 65.3 bits (152), Expect = 7e-10
Identities = 32/100 (32%), Positives = 56/100 (56%), Gaps = 6/100 (6%)
Query: 373 MIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGR 432
M + + E + + +RVG++ G V+ G++G RR ++D+W N V A++M+S+G GR
Sbjct: 678 MFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGR 737
Query: 433 VHISEETSQFLGG---SYILEEGEEVFGH---KTYFIEGR 466
+ ++EE + L ++ V G TYF+EGR
Sbjct: 738 IQVTEEVHRLLRRCPYHFVCRGKVSVKGKGEMLTYFLEGR 777
Score = 35.1 bits (77), Expect = 0.86
Identities = 17/32 (53%), Positives = 21/32 (65%)
Query: 345 LFRPFNMSCMDNVSILFADIVGFTRMSSMIEA 376
+F + DNVSILFADIVGFT ++S A
Sbjct: 10 IFHKIYIQRHDNVSILFADIVGFTGLASQCTA 41
>BC039891-1|AAH39891.1| 433|Homo sapiens ADCY7 protein protein.
Length = 433
Score = 94.7 bits (225), Expect = 1e-18
Identities = 39/78 (50%), Positives = 60/78 (76%)
Query: 373 MIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGR 432
M +AI++ G INMRVG+H+G VLCG++G R++++DVWS+DV+ AN+ME++G PGR
Sbjct: 354 MCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGR 413
Query: 433 VHISEETSQFLGGSYILE 450
VHI+E T + L + +L+
Sbjct: 414 VHITEATLKHLDEALLLQ 431
Score = 41.5 bits (93), Expect = 0.010
Identities = 36/127 (28%), Positives = 65/127 (51%), Gaps = 14/127 (11%)
Query: 247 MFVRILLQLCVHIIGV-HIYLMTFVRMRGTFMKVGQSLLVRRQLEMEKQLKEKMIHSVMP 305
+ ++ LC ++ G H + M R F + + +RR+L +EK+ +E ++ SV+P
Sbjct: 180 LLANAVIFLCGNLTGAFHKHQMQDAS-RDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLP 238
Query: 306 PKLASNLMNEQVTEADTNVKTYHNPLNSRISNPGSDIKSLFRPFNMSCMDNVSILFADIV 365
++ M + E +K + R P ++ SL+ + NVSIL+ADIV
Sbjct: 239 AHISMG-MKLAIIE---RLKEH----GDRRCMPDNNFHSLY----VKRHQNVSILYADIV 286
Query: 366 GFTRMSS 372
GFT+++S
Sbjct: 287 GFTQLAS 293
>AB209496-1|BAD92733.1| 1045|Homo sapiens brain adenylate cyclase 1
variant protein.
Length = 1045
Score = 94.7 bits (225), Expect = 1e-18
Identities = 43/87 (49%), Positives = 60/87 (68%), Gaps = 3/87 (3%)
Query: 373 MIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGR 432
MI+ I +NMRVG+HTG VLCG++G R++++DVWSNDVT AN ME++G PG+
Sbjct: 365 MIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGK 424
Query: 433 VHISEETSQFLGGSYILEEGEEVFGHK 459
VHI++ T L G Y +E G +GH+
Sbjct: 425 VHITKTTLACLNGDYEVEPG---YGHE 448
Score = 63.7 bits (148), Expect = 2e-09
Identities = 24/71 (33%), Positives = 45/71 (63%)
Query: 373 MIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGR 432
M + + E + + +RVG++ G V+ G++G RR ++D+W N V A++M+S+G GR
Sbjct: 945 MFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGR 1004
Query: 433 VHISEETSQFL 443
+ ++EE + L
Sbjct: 1005 IQVTEEVHRLL 1015
Score = 40.7 bits (91), Expect = 0.017
Identities = 35/135 (25%), Positives = 62/135 (45%), Gaps = 24/135 (17%)
Query: 242 WQASGMFVRILLQLCVHIIGVHIYLMTFVRMRGTFMKVGQSLLVRRQLEMEKQLKEKMIH 301
W+ G LL + V++ GV + ++T R F++ + R +LE E + +E+++
Sbjct: 198 WRTLG--ANALLFVGVNMYGVFVRILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLM 255
Query: 302 SVMPPKLASNLMNEQVTEADTNVKTYHNPLNSRISNPGSDIKSLFRPFNMSCMDNVSILF 361
S++P +A + + + + +F + DNVSILF
Sbjct: 256 SLLPRNVAMEMKEDFLKPPER----------------------IFHKIYIQRHDNVSILF 293
Query: 362 ADIVGFTRMSSMIEA 376
ADIVGFT ++S A
Sbjct: 294 ADIVGFTGLASQCTA 308
>AK126468-1|BAC86560.1| 419|Homo sapiens protein ( Homo sapiens
cDNA FLJ44504 fis, clone UTERU3001240, highly similar
to Adenylate cyclase, type IV (EC 4.6.1.1). ).
Length = 419
Score = 92.3 bits (219), Expect = 5e-18
Identities = 38/67 (56%), Positives = 53/67 (79%)
Query: 385 GEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGRVHISEETSQFLG 444
G INMRVGVH+G+VLCG++G +++++DVWS+DVT AN ME+ G PGRVHI+ T L
Sbjct: 53 GVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLA 112
Query: 445 GSYILEE 451
G+Y +E+
Sbjct: 113 GAYAVED 119
>U65473-1|AAD00121.1| 105|Homo sapiens adenylyl cyclase type V
protein.
Length = 105
Score = 91.5 bits (217), Expect = 9e-18
Identities = 37/64 (57%), Positives = 50/64 (78%)
Query: 389 NMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGRVHISEETSQFLGGSYI 448
NMRVG+H+G V CG++G R+++FDVWSNDVT AN ME+ GK GR+HI++ T +L G Y
Sbjct: 1 NMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYE 60
Query: 449 LEEG 452
+E G
Sbjct: 61 VEPG 64
>M83533-1|AAA35523.2| 675|Homo sapiens adenylyl cyclase type V
protein.
Length = 675
Score = 65.7 bits (153), Expect = 5e-10
Identities = 32/105 (30%), Positives = 58/105 (55%), Gaps = 10/105 (9%)
Query: 372 SMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPG 431
++ E+IQE ++ +R+G+ G+V+ G++G ++ ++D+W V A++M+S+G G
Sbjct: 493 ALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSG 552
Query: 432 RVHISEETSQFL----------GGSYILEEGEEVFGHKTYFIEGR 466
R+ + EET L G Y+ E+ KTYF+ GR
Sbjct: 553 RIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGR 597
>X63282-1|CAA44921.1| 732|Homo sapiens alpha2-subunit of soluble
guanylyl cyclase protein.
Length = 732
Score = 63.7 bits (148), Expect = 2e-09
Identities = 29/71 (40%), Positives = 45/71 (63%)
Query: 373 MIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGR 432
M+E +E G I MR+G+H+G+VL G+VG R ++ ++ N+VT A+K ES P R
Sbjct: 596 MMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRR 655
Query: 433 VHISEETSQFL 443
+++S T Q L
Sbjct: 656 INVSPTTYQLL 666
>BC130488-1|AAI30489.1| 732|Homo sapiens guanylate cyclase 1,
soluble, alpha 2 protein.
Length = 732
Score = 63.7 bits (148), Expect = 2e-09
Identities = 29/71 (40%), Positives = 45/71 (63%)
Query: 373 MIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGR 432
M+E +E G I MR+G+H+G+VL G+VG R ++ ++ N+VT A+K ES P R
Sbjct: 596 MMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRR 655
Query: 433 VHISEETSQFL 443
+++S T Q L
Sbjct: 656 INVSPTTYQLL 666
>BC130484-1|AAI30485.1| 732|Homo sapiens guanylate cyclase 1,
soluble, alpha 2 protein.
Length = 732
Score = 63.7 bits (148), Expect = 2e-09
Identities = 29/71 (40%), Positives = 45/71 (63%)
Query: 373 MIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGR 432
M+E +E G I MR+G+H+G+VL G+VG R ++ ++ N+VT A+K ES P R
Sbjct: 596 MMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRR 655
Query: 433 VHISEETSQFL 443
+++S T Q L
Sbjct: 656 INVSPTTYQLL 666
>Y15723-1|CAA75738.1| 690|Homo sapiens soluble guanylyl cyclase
protein.
Length = 690
Score = 60.9 bits (141), Expect = 2e-08
Identities = 27/71 (38%), Positives = 44/71 (61%)
Query: 373 MIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGR 432
M+E E GE I MR+G+H+G+V G+VG + ++ ++ N+VT ANK ES P +
Sbjct: 556 MMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRK 615
Query: 433 VHISEETSQFL 443
+++S T + L
Sbjct: 616 INVSPTTYRLL 626
>X66534-1|CAA47145.1| 717|Homo sapiens guanylate cyclase protein.
Length = 717
Score = 60.9 bits (141), Expect = 2e-08
Identities = 27/71 (38%), Positives = 44/71 (61%)
Query: 373 MIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGR 432
M+E E GE I MR+G+H+G+V G+VG + ++ ++ N+VT ANK ES P +
Sbjct: 553 MMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRK 612
Query: 433 VHISEETSQFL 443
+++S T + L
Sbjct: 613 INVSPTTYRLL 623
>U58855-1|AAB94794.1| 690|Homo sapiens soluble guanylate cyclase
large subunit protein.
Length = 690
Score = 60.9 bits (141), Expect = 2e-08
Identities = 27/71 (38%), Positives = 44/71 (61%)
Query: 373 MIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGR 432
M+E E GE I MR+G+H+G+V G+VG + ++ ++ N+VT ANK ES P +
Sbjct: 556 MMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRK 615
Query: 433 VHISEETSQFL 443
+++S T + L
Sbjct: 616 INVSPTTYRLL 626
>BC028384-1|AAH28384.1| 690|Homo sapiens GUCY1A3 protein protein.
Length = 690
Score = 60.9 bits (141), Expect = 2e-08
Identities = 27/71 (38%), Positives = 44/71 (61%)
Query: 373 MIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGR 432
M+E E GE I MR+G+H+G+V G+VG + ++ ++ N+VT ANK ES P +
Sbjct: 556 MMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRK 615
Query: 433 VHISEETSQFL 443
+++S T + L
Sbjct: 616 INVSPTTYRLL 626
>AF233750-1|AAF64043.1| 564|Homo sapiens soluble guanylate cyclase
large subunit protein.
Length = 564
Score = 60.9 bits (141), Expect = 2e-08
Identities = 27/71 (38%), Positives = 44/71 (61%)
Query: 373 MIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGR 432
M+E E GE I MR+G+H+G+V G+VG + ++ ++ N+VT ANK ES P +
Sbjct: 430 MMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRK 489
Query: 433 VHISEETSQFL 443
+++S T + L
Sbjct: 490 INVSPTTYRLL 500
>AK075424-1|BAC11613.1| 378|Homo sapiens protein ( Homo sapiens
cDNA PSEC0115 fis, clone PLACE1000086, highly similar to
ADENYLATE CYCLASE, OLFACTIVE TYPE (EC 4.6.1.1). ).
Length = 378
Score = 59.3 bits (137), Expect = 5e-08
Identities = 34/124 (27%), Positives = 60/124 (48%), Gaps = 8/124 (6%)
Query: 362 ADIVGFTRMSSMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFA 421
AD+ F +M + + + + +R+G++ G VL G++G R+ +D+W N V A
Sbjct: 248 ADLADFAL--AMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVA 305
Query: 422 NKMESSGKPGRVHISEETSQFLG--GSYILEEGEEVFGHK----TYFIEGRQVFCPYDRE 475
++MES+G G + + EET L G + G K T+F++GR +
Sbjct: 306 SRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDKLATFPNG 365
Query: 476 QCLT 479
+T
Sbjct: 366 PSVT 369
>AF038499-1|AAD09440.2| 617|Homo sapiens soluble guanylyl cyclase
subunit beta 2 protein.
Length = 617
Score = 58.8 bits (136), Expect = 6e-08
Identities = 35/85 (41%), Positives = 51/85 (60%), Gaps = 6/85 (7%)
Query: 385 GEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGRVHISEETSQFL- 443
GE I +RVG+HTG VL +VG + ++ ++ + V A++MES G P +VH+S + L
Sbjct: 479 GEPIQLRVGIHTGPVLADVVGDKMPRYCLFGDTVNTASRMESHGLPNKVHLSPTAYRALK 538
Query: 444 -GGSYILEEGE-EVFGH---KTYFI 463
G I+E GE EV G TYF+
Sbjct: 539 NQGFKIIERGEIEVKGKGRMTTYFL 563
>BC015982-1|AAH15982.2| 130|Homo sapiens ADCY4 protein protein.
Length = 130
Score = 58.4 bits (135), Expect = 8e-08
Identities = 28/94 (29%), Positives = 52/94 (55%), Gaps = 5/94 (5%)
Query: 390 MRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGRVHISEETSQFLGGSYIL 449
+RVG++ G V+ G++G ++ ++D+W N V A++MES+G G++ ++EET+ L
Sbjct: 36 LRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSL--- 92
Query: 450 EEGEEVFGHKTYFIEGRQVFCPYDREQCLTPSNP 483
G + ++G+ C Y LT + P
Sbjct: 93 --GYTCYSRGVIKVKGKGQLCTYFLNTDLTRTGP 124
>AK056745-1|BAB71270.1| 506|Homo sapiens protein ( Homo sapiens
cDNA FLJ32183 fis, clone PLACE6001886, highly similar to
ADENYLATE CYCLASE, TYPE IV (EC 4.6.1.1). ).
Length = 506
Score = 58.4 bits (135), Expect = 8e-08
Identities = 28/94 (29%), Positives = 52/94 (55%), Gaps = 5/94 (5%)
Query: 390 MRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGRVHISEETSQFLGGSYIL 449
+RVG++ G V+ G++G ++ ++D+W N V A++MES+G G++ ++EET+ L
Sbjct: 412 LRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSL--- 468
Query: 450 EEGEEVFGHKTYFIEGRQVFCPYDREQCLTPSNP 483
G + ++G+ C Y LT + P
Sbjct: 469 --GYTCYSRGVIKVKGKGQLCTYFLNTDLTRTGP 500
>Z50053-1|CAA90393.1| 763|Homo sapiens alpha2i-subunit of soluble
guanylyl cyclase protein.
Length = 763
Score = 58.0 bits (134), Expect = 1e-07
Identities = 24/54 (44%), Positives = 38/54 (70%)
Query: 390 MRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGRVHISEETSQFL 443
MR+G+H+G+VL G+VG R ++ ++ N+VT A+K ES P R+++S T Q L
Sbjct: 644 MRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLL 697
>X74210-1|CAA52282.1| 476|Homo sapiens adenylate cyclase protein.
Length = 476
Score = 56.0 bits (129), Expect = 4e-07
Identities = 20/72 (27%), Positives = 45/72 (62%)
Query: 372 SMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPG 431
+++ + ++ +RVG++ G V+ G++G ++ ++D+W N V A++M+S+G
Sbjct: 364 ALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLD 423
Query: 432 RVHISEETSQFL 443
++ ++EETS L
Sbjct: 424 KIQVTEETSLVL 435
>L21993-1|AAA64923.1| 476|Homo sapiens adenylyl cyclase protein.
Length = 476
Score = 56.0 bits (129), Expect = 4e-07
Identities = 20/72 (27%), Positives = 45/72 (62%)
Query: 372 SMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPG 431
+++ + ++ +RVG++ G V+ G++G ++ ++D+W N V A++M+S+G
Sbjct: 364 ALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLD 423
Query: 432 RVHISEETSQFL 443
++ ++EETS L
Sbjct: 424 KIQVTEETSLVL 435
>AF070583-1|AAC28647.1| 367|Homo sapiens adenylyl cyclase protein.
Length = 367
Score = 56.0 bits (129), Expect = 4e-07
Identities = 20/72 (27%), Positives = 45/72 (62%)
Query: 372 SMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPG 431
+++ + ++ +RVG++ G V+ G++G ++ ++D+W N V A++M+S+G
Sbjct: 255 ALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLD 314
Query: 432 RVHISEETSQFL 443
++ ++EETS L
Sbjct: 315 KIQVTEETSLVL 326
>X15357-1|CAA33417.1| 1061|Homo sapiens ANP-A receptor preprotein (AA
-32 to 1029) protein.
Length = 1061
Score = 54.8 bits (126), Expect = 1e-06
Identities = 25/74 (33%), Positives = 49/74 (66%), Gaps = 2/74 (2%)
Query: 372 SMIEAIQEFD-RERG-EGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGK 429
++++A++ F R R E + +R+G+HTG V G+VG + ++ ++ + V A++MES+G+
Sbjct: 951 ALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGE 1010
Query: 430 PGRVHISEETSQFL 443
++H+S ET L
Sbjct: 1011 ALKIHLSSETKAVL 1024
>S72628-1|AAD14112.1| 415|Homo sapiens atrial natriuretic peptide
receptor guanylate protein.
Length = 415
Score = 54.8 bits (126), Expect = 1e-06
Identities = 25/74 (33%), Positives = 49/74 (66%), Gaps = 2/74 (2%)
Query: 372 SMIEAIQEFD-RERG-EGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGK 429
++++A++ F R R E + +R+G+HTG V G+VG + ++ ++ + V A++MES+G+
Sbjct: 318 ALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGE 377
Query: 430 PGRVHISEETSQFL 443
++H+S ET L
Sbjct: 378 ALKIHLSSETKAVL 391
>BC063304-1|AAH63304.1| 1061|Homo sapiens natriuretic peptide receptor
A/guanylate cyclase A (atrionatriuretic peptide re
protein.
Length = 1061
Score = 54.8 bits (126), Expect = 1e-06
Identities = 25/74 (33%), Positives = 49/74 (66%), Gaps = 2/74 (2%)
Query: 372 SMIEAIQEFD-RERG-EGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGK 429
++++A++ F R R E + +R+G+HTG V G+VG + ++ ++ + V A++MES+G+
Sbjct: 951 ALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGE 1010
Query: 430 PGRVHISEETSQFL 443
++H+S ET L
Sbjct: 1011 ALKIHLSSETKAVL 1024
>AL713889-5|CAI13614.1| 255|Homo sapiens natriuretic peptide
receptor A/guanylate cyclase A (atrionatriuretic peptide
re protein.
Length = 255
Score = 54.8 bits (126), Expect = 1e-06
Identities = 25/74 (33%), Positives = 49/74 (66%), Gaps = 2/74 (2%)
Query: 372 SMIEAIQEFD-RERG-EGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGK 429
++++A++ F R R E + +R+G+HTG V G+VG + ++ ++ + V A++MES+G+
Sbjct: 132 ALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGE 191
Query: 430 PGRVHISEETSQFL 443
++H+S ET L
Sbjct: 192 ALKIHLSSETKAVL 205
>AL713889-4|CAI13613.1| 1061|Homo sapiens natriuretic peptide receptor
A/guanylate cyclase A (atrionatriuretic peptide re
protein.
Length = 1061
Score = 54.8 bits (126), Expect = 1e-06
Identities = 25/74 (33%), Positives = 49/74 (66%), Gaps = 2/74 (2%)
Query: 372 SMIEAIQEFD-RERG-EGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGK 429
++++A++ F R R E + +R+G+HTG V G+VG + ++ ++ + V A++MES+G+
Sbjct: 951 ALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGE 1010
Query: 430 PGRVHISEETSQFL 443
++H+S ET L
Sbjct: 1011 ALKIHLSSETKAVL 1024
>AF190631-1|AAF01340.1| 1061|Homo sapiens natriuretic peptide receptor
A protein.
Length = 1061
Score = 54.8 bits (126), Expect = 1e-06
Identities = 25/74 (33%), Positives = 49/74 (66%), Gaps = 2/74 (2%)
Query: 372 SMIEAIQEFD-RERG-EGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGK 429
++++A++ F R R E + +R+G+HTG V G+VG + ++ ++ + V A++MES+G+
Sbjct: 951 ALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGE 1010
Query: 430 PGRVHISEETSQFL 443
++H+S ET L
Sbjct: 1011 ALKIHLSSETKAVL 1024
>AB010491-1|BAA31199.1| 1061|Homo sapiens natriuretic peptide A type
receptor protein.
Length = 1061
Score = 54.8 bits (126), Expect = 1e-06
Identities = 25/74 (33%), Positives = 49/74 (66%), Gaps = 2/74 (2%)
Query: 372 SMIEAIQEFD-RERG-EGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGK 429
++++A++ F R R E + +R+G+HTG V G+VG + ++ ++ + V A++MES+G+
Sbjct: 951 ALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGE 1010
Query: 430 PGRVHISEETSQFL 443
++H+S ET L
Sbjct: 1011 ALKIHLSSETKAVL 1024
>X66533-1|CAA47144.1| 619|Homo sapiens guanylate cyclase protein.
Length = 619
Score = 54.4 bits (125), Expect = 1e-06
Identities = 34/133 (25%), Positives = 66/133 (49%), Gaps = 8/133 (6%)
Query: 311 NLMNEQVTEADTNVKTYHNPLNSRISNPGSDIKSLFRPFNMSCMDNVSILFADIVGFTRM 370
NL+N+ T DT + NP ++ G + +S + I A + +
Sbjct: 448 NLLNDLYTRFDTLTDSRKNPFVYKVETVGD------KYMTVSGLPEPCIHHARSICHLAL 501
Query: 371 SSMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKP 430
M A Q + GE + + +G+HTG V+ G++G R ++ ++ N V ++ E++G+
Sbjct: 502 DMMEIAGQV--QVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEK 559
Query: 431 GRVHISEETSQFL 443
G++++SE T + L
Sbjct: 560 GKINVSEYTYRCL 572
>BC047620-1|AAH47620.2| 619|Homo sapiens guanylate cyclase 1,
soluble, beta 3 protein.
Length = 619
Score = 54.4 bits (125), Expect = 1e-06
Identities = 34/133 (25%), Positives = 66/133 (49%), Gaps = 8/133 (6%)
Query: 311 NLMNEQVTEADTNVKTYHNPLNSRISNPGSDIKSLFRPFNMSCMDNVSILFADIVGFTRM 370
NL+N+ T DT + NP ++ G + +S + I A + +
Sbjct: 448 NLLNDLYTRFDTLTDSRKNPFVYKVETVGD------KYMTVSGLPEPCIHHARSICHLAL 501
Query: 371 SSMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKP 430
M A Q + GE + + +G+HTG V+ G++G R ++ ++ N V ++ E++G+
Sbjct: 502 DMMEIAGQV--QVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEK 559
Query: 431 GRVHISEETSQFL 443
G++++SE T + L
Sbjct: 560 GKINVSEYTYRCL 572
>AF020340-1|AAB94877.1| 586|Homo sapiens soluble guanylate cyclase
beta-1 subunit protein.
Length = 586
Score = 54.4 bits (125), Expect = 1e-06
Identities = 34/133 (25%), Positives = 66/133 (49%), Gaps = 8/133 (6%)
Query: 311 NLMNEQVTEADTNVKTYHNPLNSRISNPGSDIKSLFRPFNMSCMDNVSILFADIVGFTRM 370
NL+N+ T DT + NP ++ G + +S + I A + +
Sbjct: 415 NLLNDLYTRFDTLTDSRKNPFVYKVETVGD------KYMTVSGLPEPCIHHARSICHLAL 468
Query: 371 SSMIEAIQEFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKP 430
M A Q + GE + + +G+HTG V+ G++G R ++ ++ N V ++ E++G+
Sbjct: 469 DMMEIAGQV--QVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEK 526
Query: 431 GRVHISEETSQFL 443
G++++SE T + L
Sbjct: 527 GKINVSEYTYRCL 539
>BC023017-1|AAH23017.1| 618|Homo sapiens NPR2 protein protein.
Length = 618
Score = 51.6 bits (118), Expect = 9e-06
Identities = 24/74 (32%), Positives = 47/74 (63%), Gaps = 2/74 (2%)
Query: 372 SMIEAIQEFD-RERG-EGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGK 429
++++A+ F R R + + +R+GVHTG V G+VG + ++ ++ + V A++MES+G+
Sbjct: 507 ALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQ 566
Query: 430 PGRVHISEETSQFL 443
++H+S T L
Sbjct: 567 ALKIHVSSTTKDAL 580
>AL133410-13|CAI10987.1| 1047|Homo sapiens natriuretic peptide
receptor B/guanylate cyclase B (atrionatriuretic peptide
re protein.
Length = 1047
Score = 51.6 bits (118), Expect = 9e-06
Identities = 24/74 (32%), Positives = 47/74 (63%), Gaps = 2/74 (2%)
Query: 372 SMIEAIQEFD-RERG-EGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGK 429
++++A+ F R R + + +R+GVHTG V G+VG + ++ ++ + V A++MES+G+
Sbjct: 936 ALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQ 995
Query: 430 PGRVHISEETSQFL 443
++H+S T L
Sbjct: 996 ALKIHVSSTTKDAL 1009
>AB005647-1|BAA81737.1| 1047|Homo sapiens atrial natriuretic peptide
Btype receptor protein.
Length = 1047
Score = 51.6 bits (118), Expect = 9e-06
Identities = 24/74 (32%), Positives = 47/74 (63%), Gaps = 2/74 (2%)
Query: 372 SMIEAIQEFD-RERG-EGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGK 429
++++A+ F R R + + +R+GVHTG V G+VG + ++ ++ + V A++MES+G+
Sbjct: 936 ALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQ 995
Query: 430 PGRVHISEETSQFL 443
++H+S T L
Sbjct: 996 ALKIHVSSTTKDAL 1009
>L37378-1|AAA74451.1| 1108|Homo sapiens guanylyl cyclase protein.
Length = 1108
Score = 51.2 bits (117), Expect = 1e-05
Identities = 25/68 (36%), Positives = 42/68 (61%), Gaps = 3/68 (4%)
Query: 388 INMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGRVHISEETSQFLGGSY 447
+ +R+G+H+G V+ G+VG ++ ++ + V A++MES+G P R+H+S T L
Sbjct: 977 VRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQN-- 1034
Query: 448 ILEEGEEV 455
L EG EV
Sbjct: 1035 -LSEGYEV 1041
>AL031387-4|CAB41303.1| 1108|Homo sapiens guanylate cyclase 2F,
retinal protein.
Length = 1108
Score = 51.2 bits (117), Expect = 1e-05
Identities = 25/68 (36%), Positives = 42/68 (61%), Gaps = 3/68 (4%)
Query: 388 INMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGRVHISEETSQFLGGSY 447
+ +R+G+H+G V+ G+VG ++ ++ + V A++MES+G P R+H+S T L
Sbjct: 977 VRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQN-- 1034
Query: 448 ILEEGEEV 455
L EG EV
Sbjct: 1035 -LSEGYEV 1041
>S57551-1|AAB19934.2| 1073|Homo sapiens guanylate cyclase-coupled
enterotoxin receptor protein.
Length = 1073
Score = 48.8 bits (111), Expect = 7e-05
Identities = 23/65 (35%), Positives = 39/65 (60%)
Query: 379 EFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGRVHISEE 438
E + G I +R+GVH+G G+VG + ++ ++ + V A++MES+G P R+H+S
Sbjct: 908 ELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGS 967
Query: 439 TSQFL 443
T L
Sbjct: 968 TIAIL 972
>M73489-1|AAA36655.1| 1073|Homo sapiens heat-stable enterotoxin
receptor protein.
Length = 1073
Score = 48.8 bits (111), Expect = 7e-05
Identities = 23/65 (35%), Positives = 39/65 (60%)
Query: 379 EFDRERGEGINMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGRVHISEE 438
E + G I +R+GVH+G G+VG + ++ ++ + V A++MES+G P R+H+S
Sbjct: 908 ELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGS 967
Query: 439 TSQFL 443
T L
Sbjct: 968 TIAIL 972
>M92432-1|AAA60547.1| 1103|Homo sapiens guanylyl cyclase protein.
Length = 1103
Score = 45.6 bits (103), Expect = 6e-04
Identities = 17/52 (32%), Positives = 35/52 (67%)
Query: 388 INMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGRVHISEET 439
+ +R+G+H+G + G+VG ++ ++ + V A++MES+G P R+H++ T
Sbjct: 973 VRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLST 1024
Score = 32.3 bits (70), Expect = 6.1
Identities = 18/71 (25%), Positives = 33/71 (46%)
Query: 311 NLMNEQVTEADTNVKTYHNPLNSRISNPGSDIKSLFRPFNMSCMDNVSILFADIVGFTRM 370
+L+ E+ E + + L + ++ P + V++ F+DIVGFT +
Sbjct: 833 DLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTI 892
Query: 371 SSMIEAIQEFD 381
S+M E I+ D
Sbjct: 893 SAMSEPIEVVD 903
>AJ222657-1|CAA10914.1| 1103|Homo sapiens guanylyl cyclase protein.
Length = 1103
Score = 45.6 bits (103), Expect = 6e-04
Identities = 17/52 (32%), Positives = 35/52 (67%)
Query: 388 INMRVGVHTGTVLCGIVGTRRFKFDVWSNDVTFANKMESSGKPGRVHISEET 439
+ +R+G+H+G + G+VG ++ ++ + V A++MES+G P R+H++ T
Sbjct: 973 VRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLST 1024
Score = 32.3 bits (70), Expect = 6.1
Identities = 18/71 (25%), Positives = 33/71 (46%)
Query: 311 NLMNEQVTEADTNVKTYHNPLNSRISNPGSDIKSLFRPFNMSCMDNVSILFADIVGFTRM 370
+L+ E+ E + + L + ++ P + V++ F+DIVGFT +
Sbjct: 833 DLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTI 892
Query: 371 SSMIEAIQEFD 381
S+M E I+ D
Sbjct: 893 SAMSEPIEVVD 903
>U65474-1|AAD00122.1| 74|Homo sapiens adenylyl cyclase type VI
protein.
Length = 74
Score = 39.9 bits (89), Expect = 0.030
Identities = 16/32 (50%), Positives = 22/32 (68%)
Query: 421 ANKMESSGKPGRVHISEETSQFLGGSYILEEG 452
AN ME+ G+ GR+HI+ T Q+L G Y +E G
Sbjct: 2 ANHMEAGGRAGRIHITRATLQYLNGDYEVEPG 33
>AC069008-1|AAS07467.1| 105|Homo sapiens unknown protein.
Length = 105
Score = 35.1 bits (77), Expect = 0.86
Identities = 17/32 (53%), Positives = 21/32 (65%)
Query: 345 LFRPFNMSCMDNVSILFADIVGFTRMSSMIEA 376
+F + DNVSILFADIVGFT ++S A
Sbjct: 12 IFHKIYIQRHDNVSILFADIVGFTGLASQCTA 43
>BC101476-1|AAI01477.1| 1015|Homo sapiens non-SMC condensin I complex,
subunit G protein.
Length = 1015
Score = 34.3 bits (75), Expect = 1.5
Identities = 21/85 (24%), Positives = 41/85 (48%), Gaps = 2/85 (2%)
Query: 599 TPLHGIKKEDASDKTIHLLERGD--VSVCVQSSNGYQQVPIVIESQDNKRPLQSSSKLNI 656
TPL G+K AS T RG V+V +++ Q ES +S K+ +
Sbjct: 931 TPLRGVKATQASKSTQLKTNRGQRKVTVSARTNRRCQTAEADSESDHEVPEPESEMKMRL 990
Query: 657 PQINETSSFDREIIDIRSYLSQSRS 681
P+ +T++ ++ +++ +L++ S
Sbjct: 991 PRRAKTAALEKSKLNLAQFLNEDLS 1015
>BC068467-1|AAH68467.1| 1015|Homo sapiens non-SMC condensin I complex,
subunit G protein.
Length = 1015
Score = 34.3 bits (75), Expect = 1.5
Identities = 21/85 (24%), Positives = 41/85 (48%), Gaps = 2/85 (2%)
Query: 599 TPLHGIKKEDASDKTIHLLERGD--VSVCVQSSNGYQQVPIVIESQDNKRPLQSSSKLNI 656
TPL G+K AS T RG V+V +++ Q ES +S K+ +
Sbjct: 931 TPLRGVKATQASKSTQLKTNRGQRKVTVSARTNRRCQTAEADSESDHEVPEPESEMKMRL 990
Query: 657 PQINETSSFDREIIDIRSYLSQSRS 681
P+ +T++ ++ +++ +L++ S
Sbjct: 991 PRRAKTAALEKSKLNLAQFLNEDLS 1015
>BC000827-1|AAH00827.1| 435|Homo sapiens NCAPG protein protein.
Length = 435
Score = 34.3 bits (75), Expect = 1.5
Identities = 21/85 (24%), Positives = 41/85 (48%), Gaps = 2/85 (2%)
Query: 599 TPLHGIKKEDASDKTIHLLERGD--VSVCVQSSNGYQQVPIVIESQDNKRPLQSSSKLNI 656
TPL G+K AS T RG V+V +++ Q ES +S K+ +
Sbjct: 351 TPLRGVKATQASKSTQLKTNRGQRKVTVSARTNRRCQTAEADSESDHEVPEPESEMKMRL 410
Query: 657 PQINETSSFDREIIDIRSYLSQSRS 681
P+ +T++ ++ +++ +L++ S
Sbjct: 411 PRRAKTAALEKSKLNLAQFLNEDLS 435
>AK027511-1|BAB55165.1| 524|Homo sapiens protein ( Homo sapiens
cDNA FLJ14605 fis, clone NT2RP1000439, weakly similar to
Xenopus laevis chromosome condensation protein XCAP-G
mRNA. ).
Length = 524
Score = 34.3 bits (75), Expect = 1.5
Identities = 21/85 (24%), Positives = 41/85 (48%), Gaps = 2/85 (2%)
Query: 599 TPLHGIKKEDASDKTIHLLERGD--VSVCVQSSNGYQQVPIVIESQDNKRPLQSSSKLNI 656
TPL G+K AS T RG V+V +++ Q ES +S K+ +
Sbjct: 440 TPLRGVKATQASKSTQLKTNRGQRKVTVSARTNRRCQTAEADSESDHEVPEPESEMKMRL 499
Query: 657 PQINETSSFDREIIDIRSYLSQSRS 681
P+ +T++ ++ +++ +L++ S
Sbjct: 500 PRRAKTAALEKSKLNLAQFLNEDLS 524
>AK023147-1|BAB14429.1| 960|Homo sapiens protein ( Homo sapiens
cDNA FLJ13085 fis, clone NT2RP3002081, moderately
similar to Xenopus laevis chromosome condensation
protein XCAP-G ).
Length = 960
Score = 34.3 bits (75), Expect = 1.5
Identities = 21/85 (24%), Positives = 41/85 (48%), Gaps = 2/85 (2%)
Query: 599 TPLHGIKKEDASDKTIHLLERGD--VSVCVQSSNGYQQVPIVIESQDNKRPLQSSSKLNI 656
TPL G+K AS T RG V+V +++ Q ES +S K+ +
Sbjct: 876 TPLRGVKATQASKSTQLKTNRGQRKVTVSARTNRRCQTAEADSESDHEVPEPESEMKMRL 935
Query: 657 PQINETSSFDREIIDIRSYLSQSRS 681
P+ +T++ ++ +++ +L++ S
Sbjct: 936 PRRAKTAALEKSKLNLAQFLNEDLS 960
>AK022512-1|BAB14069.1| 1015|Homo sapiens protein ( Homo sapiens cDNA
FLJ12450 fis, clone NT2RM1000354, moderately similar to
Xenopus laevis chromosome condensation protein XCAP-G ).
Length = 1015
Score = 34.3 bits (75), Expect = 1.5
Identities = 21/85 (24%), Positives = 41/85 (48%), Gaps = 2/85 (2%)
Query: 599 TPLHGIKKEDASDKTIHLLERGD--VSVCVQSSNGYQQVPIVIESQDNKRPLQSSSKLNI 656
TPL G+K AS T RG V+V +++ Q ES +S K+ +
Sbjct: 931 TPLRGVKATQASKSTQLKTNRGQRKVTVSARTNRRCQTAEADSESDHEVPEPESEMKMRL 990
Query: 657 PQINETSSFDREIIDIRSYLSQSRS 681
P+ +T++ ++ +++ +L++ S
Sbjct: 991 PRRAKTAALEKSKLNLAQFLNEDLS 1015
>AF331796-1|AAG49627.1| 1015|Homo sapiens condensin subunit CAP-G
protein.
Length = 1015
Score = 34.3 bits (75), Expect = 1.5
Identities = 21/85 (24%), Positives = 41/85 (48%), Gaps = 2/85 (2%)
Query: 599 TPLHGIKKEDASDKTIHLLERGD--VSVCVQSSNGYQQVPIVIESQDNKRPLQSSSKLNI 656
TPL G+K AS T RG V+V +++ Q ES +S K+ +
Sbjct: 931 TPLRGVKATQASKSTQLKTNRGQRKVTVSARTNRRCQTAEADSESDHEVPEPESEMKMRL 990
Query: 657 PQINETSSFDREIIDIRSYLSQSRS 681
P+ +T++ ++ +++ +L++ S
Sbjct: 991 PRRAKTAALEKSKLNLAQFLNEDLS 1015
>AB013299-1|BAB21557.1| 1015|Homo sapiens chromosome-associated
protein-G protein.
Length = 1015
Score = 34.3 bits (75), Expect = 1.5
Identities = 21/85 (24%), Positives = 41/85 (48%), Gaps = 2/85 (2%)
Query: 599 TPLHGIKKEDASDKTIHLLERGD--VSVCVQSSNGYQQVPIVIESQDNKRPLQSSSKLNI 656
TPL G+K AS T RG V+V +++ Q ES +S K+ +
Sbjct: 931 TPLRGVKATQASKSTQLKTNRGQRKVTVSARTNRRCQTAEADSESDHEVPEPESEMKMRL 990
Query: 657 PQINETSSFDREIIDIRSYLSQSRS 681
P+ +T++ ++ +++ +L++ S
Sbjct: 991 PRRAKTAALEKSKLNLAQFLNEDLS 1015
>AJ626861-1|CAF25188.1| 3628|Homo sapiens VPS13C-2B protein protein.
Length = 3628
Score = 32.7 bits (71), Expect = 4.6
Identities = 42/173 (24%), Positives = 76/173 (43%), Gaps = 17/173 (9%)
Query: 512 KTEDKLNLRKPNSNNFLSPTPFNFRAKASSLPSILDSDTELDDNRDKGLTERTDSSSKSP 571
+T L+LR ++L F + S L ILD T +++D+GL + T+SS +
Sbjct: 683 ETRKVLDLRINLKPSYLVVPQTGFHHEKSDL-LILDFGTFQLNSKDQGLQKTTNSSLEEI 741
Query: 572 TSVGSYGKYTNKLKN-----------WKVPRFLRKHSDTPLHGIKKEDASDKTIHLLERG 620
+Y K+ ++KN WK RF +H T +H ++ D + +
Sbjct: 742 MD-KAYDKFDVEIKNVQLLFARAEETWKKCRF--QHPST-MHILQPMDIHVELAKAMVEK 797
Query: 621 DVSVC-VQSSNGYQQVPIVIESQDNKRPLQSSSKLNIPQINETSSFDREIIDI 672
D+ + + S G + + I Q K L + + +PQ + S +R++ I
Sbjct: 798 DIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIPLPQKSSAQSPERQVSSI 850
>AJ626860-1|CAF25187.1| 3585|Homo sapiens VPS13C-1B protein protein.
Length = 3585
Score = 32.7 bits (71), Expect = 4.6
Identities = 42/173 (24%), Positives = 76/173 (43%), Gaps = 17/173 (9%)
Query: 512 KTEDKLNLRKPNSNNFLSPTPFNFRAKASSLPSILDSDTELDDNRDKGLTERTDSSSKSP 571
+T L+LR ++L F + S L ILD T +++D+GL + T+SS +
Sbjct: 640 ETRKVLDLRINLKPSYLVVPQTGFHHEKSDL-LILDFGTFQLNSKDQGLQKTTNSSLEEI 698
Query: 572 TSVGSYGKYTNKLKN-----------WKVPRFLRKHSDTPLHGIKKEDASDKTIHLLERG 620
+Y K+ ++KN WK RF +H T +H ++ D + +
Sbjct: 699 MD-KAYDKFDVEIKNVQLLFARAEETWKKCRF--QHPST-MHILQPMDIHVELAKAMVEK 754
Query: 621 DVSVC-VQSSNGYQQVPIVIESQDNKRPLQSSSKLNIPQINETSSFDREIIDI 672
D+ + + S G + + I Q K L + + +PQ + S +R++ I
Sbjct: 755 DIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIPLPQKSSAQSPERQVSSI 807
>AJ608771-1|CAE75583.1| 3753|Homo sapiens VPS13C-2A protein protein.
Length = 3753
Score = 32.7 bits (71), Expect = 4.6
Identities = 42/173 (24%), Positives = 76/173 (43%), Gaps = 17/173 (9%)
Query: 512 KTEDKLNLRKPNSNNFLSPTPFNFRAKASSLPSILDSDTELDDNRDKGLTERTDSSSKSP 571
+T L+LR ++L F + S L ILD T +++D+GL + T+SS +
Sbjct: 683 ETRKVLDLRINLKPSYLVVPQTGFHHEKSDL-LILDFGTFQLNSKDQGLQKTTNSSLEEI 741
Query: 572 TSVGSYGKYTNKLKN-----------WKVPRFLRKHSDTPLHGIKKEDASDKTIHLLERG 620
+Y K+ ++KN WK RF +H T +H ++ D + +
Sbjct: 742 MD-KAYDKFDVEIKNVQLLFARAEETWKKCRF--QHPST-MHILQPMDIHVELAKAMVEK 797
Query: 621 DVSVC-VQSSNGYQQVPIVIESQDNKRPLQSSSKLNIPQINETSSFDREIIDI 672
D+ + + S G + + I Q K L + + +PQ + S +R++ I
Sbjct: 798 DIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIPLPQKSSAQSPERQVSSI 850
>AJ608770-1|CAE75582.1| 3710|Homo sapiens VPS13C-1A protein protein.
Length = 3710
Score = 32.7 bits (71), Expect = 4.6
Identities = 42/173 (24%), Positives = 76/173 (43%), Gaps = 17/173 (9%)
Query: 512 KTEDKLNLRKPNSNNFLSPTPFNFRAKASSLPSILDSDTELDDNRDKGLTERTDSSSKSP 571
+T L+LR ++L F + S L ILD T +++D+GL + T+SS +
Sbjct: 640 ETRKVLDLRINLKPSYLVVPQTGFHHEKSDL-LILDFGTFQLNSKDQGLQKTTNSSLEEI 698
Query: 572 TSVGSYGKYTNKLKN-----------WKVPRFLRKHSDTPLHGIKKEDASDKTIHLLERG 620
+Y K+ ++KN WK RF +H T +H ++ D + +
Sbjct: 699 MD-KAYDKFDVEIKNVQLLFARAEETWKKCRF--QHPST-MHILQPMDIHVELAKAMVEK 754
Query: 621 DVSVC-VQSSNGYQQVPIVIESQDNKRPLQSSSKLNIPQINETSSFDREIIDI 672
D+ + + S G + + I Q K L + + +PQ + S +R++ I
Sbjct: 755 DIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIPLPQKSSAQSPERQVSSI 807
>AB037842-1|BAA92659.1| 1463|Homo sapiens KIAA1421 protein protein.
Length = 1463
Score = 32.7 bits (71), Expect = 4.6
Identities = 42/173 (24%), Positives = 76/173 (43%), Gaps = 17/173 (9%)
Query: 512 KTEDKLNLRKPNSNNFLSPTPFNFRAKASSLPSILDSDTELDDNRDKGLTERTDSSSKSP 571
+T L+LR ++L F + S L ILD T +++D+GL + T+SS +
Sbjct: 707 ETRKVLDLRINLKPSYLVVPQTGFHHEKSDL-LILDFGTFQLNSKDQGLQKTTNSSLEEI 765
Query: 572 TSVGSYGKYTNKLKN-----------WKVPRFLRKHSDTPLHGIKKEDASDKTIHLLERG 620
+Y K+ ++KN WK RF +H T +H ++ D + +
Sbjct: 766 MD-KAYDKFDVEIKNVQLLFARAEETWKKCRF--QHPST-MHILQPMDIHVELAKAMVEK 821
Query: 621 DVSVC-VQSSNGYQQVPIVIESQDNKRPLQSSSKLNIPQINETSSFDREIIDI 672
D+ + + S G + + I Q K L + + +PQ + S +R++ I
Sbjct: 822 DIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIPLPQKSSAQSPERQVSSI 874
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.321 0.135 0.403
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 91,790,064
Number of Sequences: 224733
Number of extensions: 3756446
Number of successful extensions: 11477
Number of sequences better than 10.0: 80
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 11276
Number of HSP's gapped (non-prelim): 198
length of query: 705
length of database: 73,234,838
effective HSP length: 95
effective length of query: 610
effective length of database: 51,885,203
effective search space: 31649973830
effective search space used: 31649973830
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.9 bits)
S2: 69 (31.9 bits)
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