Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001235-TA|BGIBMGA001235-PA|IPR001474|GTP cyclohydrolase
I
(232 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P48596 Cluster: GTP cyclohydrolase I; n=6; cellular org... 397 e-109
UniRef50_P30793 Cluster: GTP cyclohydrolase I; n=78; cellular or... 297 1e-79
UniRef50_Q19980 Cluster: GTP cyclohydrolase I; n=89; cellular or... 292 6e-78
UniRef50_A6QSY1 Cluster: GTP cyclohydrolase I; n=3; cellular org... 254 1e-66
UniRef50_Q8YLL1 Cluster: GTP cyclohydrolase I 1; n=29; Bacteria|... 250 3e-65
UniRef50_Q94465 Cluster: GTP cyclohydrolase I; n=2; Dictyosteliu... 243 3e-63
UniRef50_P51599 Cluster: GTP cyclohydrolase I; n=14; Ascomycota|... 237 2e-61
UniRef50_Q8KEA8 Cluster: GTP cyclohydrolase I; n=46; Bacteria|Re... 231 1e-59
UniRef50_Q9RYB4 Cluster: GTP cyclohydrolase I; n=5; Bacteria|Rep... 224 1e-57
UniRef50_Q6F9M5 Cluster: GTP cyclohydrolase I; n=3; cellular org... 217 2e-55
UniRef50_A5UR68 Cluster: GTP cyclohydrolase I; n=7; Bacteria|Rep... 217 3e-55
UniRef50_A5WE14 Cluster: GTP cyclohydrolase I; n=4; Pseudomonada... 200 3e-50
UniRef50_Q4SEZ7 Cluster: Chromosome 1 SCAF14609, whole genome sh... 195 9e-49
UniRef50_Q2Q448 Cluster: GTP cyclohydrolase I; n=1; Toxoplasma g... 187 2e-46
UniRef50_Q2GYY2 Cluster: Putative uncharacterized protein; n=1; ... 185 1e-45
UniRef50_Q8G0L4 Cluster: GTP cyclohydrolase I; n=20; Bacteria|Re... 183 4e-45
UniRef50_Q8G3S1 Cluster: GTP cyclohydrolase I; n=4; Bifidobacter... 178 8e-44
UniRef50_A5EFZ1 Cluster: GTP cyclohydrolase I; n=6; Proteobacter... 178 1e-43
UniRef50_Q3WEZ6 Cluster: GTP cyclohydrolase I; n=7; Bacteria|Rep... 177 1e-43
UniRef50_Q0CVT9 Cluster: GTP cyclohydrolase I; n=1; Aspergillus ... 176 3e-43
UniRef50_Q9PC02 Cluster: GTP cyclohydrolase I; n=16; Bacteria|Re... 176 4e-43
UniRef50_P0C0C1 Cluster: GTP cyclohydrolase I; n=23; Bacteria|Re... 176 4e-43
UniRef50_Q92QB4 Cluster: GTP cyclohydrolase I; n=49; Proteobacte... 175 1e-42
UniRef50_A4G565 Cluster: GTP cyclohydrolase I; n=2; Betaproteoba... 174 1e-42
UniRef50_A6SZ52 Cluster: GTP cyclohydrolase I; n=2; root|Rep: GT... 173 3e-42
UniRef50_Q89IW2 Cluster: GTP cyclohydrolase I; n=13; Bacteria|Re... 173 4e-42
UniRef50_Q5NN57 Cluster: GTP cyclohydrolase I; n=4; Sphingomonad... 172 7e-42
UniRef50_O69531 Cluster: GTP cyclohydrolase I; n=98; Bacteria|Re... 170 2e-41
UniRef50_Q68WZ4 Cluster: GTP cyclohydrolase 1; n=25; Bacteria|Re... 169 4e-41
UniRef50_Q6NF93 Cluster: GTP cyclohydrolase I; n=8; Bacteria|Rep... 167 2e-40
UniRef50_A2U8J6 Cluster: GTP cyclohydrolase I; n=2; Bacillus|Rep... 167 3e-40
UniRef50_Q7VFG4 Cluster: GTP cyclohydrolase I; n=6; Helicobacter... 162 8e-39
UniRef50_UPI0000DADB56 Cluster: hypothetical protein RcanM_01000... 161 2e-38
UniRef50_A4QTK3 Cluster: Putative uncharacterized protein; n=1; ... 158 1e-37
UniRef50_A2BL58 Cluster: GTP cyclohydrolase I; n=2; Thermoprotei... 157 2e-37
UniRef50_A7QSC6 Cluster: Chromosome chr3 scaffold_158, whole gen... 153 4e-36
UniRef50_Q1IAJ6 Cluster: Putative GTP cyclohydrolase I; n=1; Pse... 153 5e-36
UniRef50_Q82Z12 Cluster: GTP cyclohydrolase I; n=1; Enterococcus... 144 1e-33
UniRef50_A5Z385 Cluster: Putative uncharacterized protein; n=1; ... 143 4e-33
UniRef50_A0RYT5 Cluster: GTP cyclohydrolase I; n=2; Thermoprotei... 142 5e-33
UniRef50_Q88ST4 Cluster: GTP cyclohydrolase I; n=11; Lactobacill... 140 2e-32
UniRef50_Q97D54 Cluster: GTP cyclohydrolase I; n=7; Clostridium|... 140 3e-32
UniRef50_A1SM21 Cluster: GTP cyclohydrolase I precursor; n=7; Ac... 139 5e-32
UniRef50_Q8RH43 Cluster: GTP cyclohydrolase I; n=3; Fusobacteriu... 134 1e-30
UniRef50_Q5HBC9 Cluster: GTP cyclohydrolase I; n=4; canis group|... 128 9e-29
UniRef50_Q1Q0A8 Cluster: Strongly similar to GTP cyclohydrolase ... 128 9e-29
UniRef50_Q2JC68 Cluster: GTP cyclohydrolase I; n=1; Frankia sp. ... 128 1e-28
UniRef50_Q6MK87 Cluster: FolE protein; n=1; Bdellovibrio bacteri... 127 3e-28
UniRef50_Q5PAR5 Cluster: GTP cyclohydrolase; n=1; Anaplasma marg... 126 5e-28
UniRef50_Q2GK14 Cluster: GTP cyclohydrolase I; n=2; Anaplasma ph... 126 5e-28
UniRef50_Q971G9 Cluster: GTP cyclohydrolase I; n=4; Sulfolobacea... 126 6e-28
UniRef50_Q8S3C2 Cluster: GTP cyclohydrolase I; n=7; core eudicot... 122 8e-27
UniRef50_Q8ZG15 Cluster: GTP cyclohydrolase I; n=129; root|Rep: ... 122 8e-27
UniRef50_Q1FI35 Cluster: GTP cyclohydrolase I; n=1; Clostridium ... 121 1e-26
UniRef50_A4CGT7 Cluster: GTP cyclohydrolase I; n=1; Robiginitale... 121 1e-26
UniRef50_Q8T649 Cluster: GTP cyclohydrolase I; n=3; Plasmodium y... 120 2e-26
UniRef50_Q6SIF0 Cluster: GTP cyclohydrolase I; n=1; Plasmodium k... 120 3e-26
UniRef50_O97071 Cluster: GTP cyclohydrolase I; n=6; Plasmodium|R... 119 5e-26
UniRef50_Q23AG3 Cluster: GTP cyclohydrolase I family protein; n=... 119 7e-26
UniRef50_Q01A10 Cluster: GTP cyclohydrolase I; n=2; Ostreococcus... 118 1e-25
UniRef50_Q7XM20 Cluster: OSJNBa0084K01.11 protein; n=4; Oryza sa... 118 2e-25
UniRef50_A5K040 Cluster: GTP cyclohydrolase I, putative; n=1; Pl... 117 2e-25
UniRef50_Q5V5Y0 Cluster: GTP cyclohydrolase I; n=1; Haloarcula m... 113 4e-24
UniRef50_Q6ME26 Cluster: Probable GTP cyclohydrolase I; n=1; Can... 111 1e-23
UniRef50_UPI00015BB290 Cluster: GTP cyclohydrolase; n=1; Ignicoc... 109 6e-23
UniRef50_A3J0S0 Cluster: GTP cyclohydrolase I; n=28; Bacteroidet... 109 8e-23
UniRef50_A6RNT4 Cluster: Putative uncharacterized protein; n=2; ... 107 2e-22
UniRef50_Q19Z80 Cluster: Gp6; n=4; root|Rep: Gp6 - Mycobacterium... 105 1e-21
UniRef50_Q8ZWW5 Cluster: GTP cyclohydrolase I; n=4; Pyrobaculum|... 103 5e-21
UniRef50_A4SVK2 Cluster: GTP cyclohydrolase I; n=20; Bacteria|Re... 101 2e-20
UniRef50_UPI000038E307 Cluster: hypothetical protein Faci_030017... 100 6e-20
UniRef50_A5GUC6 Cluster: GTP cyclohydrolase I; n=28; Cyanobacter... 100 6e-20
UniRef50_Q7N3C4 Cluster: Similarities with GTP cyclohydrolase I;... 96 6e-19
UniRef50_Q8XZK8 Cluster: GTP cyclohydrolase I; n=29; Betaproteob... 96 6e-19
UniRef50_A7JLM6 Cluster: GTP cyclohydrolase I; n=11; Francisella... 88 2e-16
UniRef50_Q08SR8 Cluster: GTP cyclohydrolase I 2; n=2; Cystobacte... 87 4e-16
UniRef50_A7HBJ5 Cluster: GTP cyclohydrolase I; n=2; Anaeromyxoba... 86 8e-16
UniRef50_Q2GDH9 Cluster: GTP cyclohydrolase I; n=1; Neorickettsi... 84 3e-15
UniRef50_Q83FV8 Cluster: GTP cyclohydrolase I; n=2; Tropheryma w... 77 5e-13
UniRef50_UPI0000F1DBDC Cluster: PREDICTED: similar to GTP cycloh... 66 9e-10
UniRef50_A0YW77 Cluster: GTP cyclohydrolase I; n=1; Lyngbya sp. ... 39 0.12
UniRef50_Q9WZP8 Cluster: NADPH-dependent 7-cyano-7-deazaguanine ... 38 0.16
UniRef50_Q4EE10 Cluster: GTP cyclohydrolase I; n=1; Listeria mon... 34 2.6
UniRef50_Q5FLA3 Cluster: Negative regulator genetic competence; ... 34 3.5
UniRef50_Q9L4X2 Cluster: NysJ; n=3; Streptomyces|Rep: NysJ - Str... 33 6.1
UniRef50_UPI00006A220F Cluster: UPI00006A220F related cluster; n... 33 8.0
UniRef50_Q9F719 Cluster: NADPH-dependent 7-cyano-7-deazaguanine ... 33 8.0
UniRef50_P41437 Cluster: Apoptosis inhibitor 3; n=2; Nucleopolyh... 33 8.0
>UniRef50_P48596 Cluster: GTP cyclohydrolase I; n=6; cellular
organisms|Rep: GTP cyclohydrolase I - Drosophila
melanogaster (Fruit fly)
Length = 324
Score = 397 bits (978), Expect = e-109
Identities = 188/207 (90%), Positives = 199/207 (96%)
Query: 26 GHENCTFHHDLELDHRPPTREALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLF 85
GHE CTFHHDLELDH+PPTREALLPDMA SYRLLL GLGE+P+R GL+KTPERAAKAML+
Sbjct: 118 GHEKCTFHHDLELDHKPPTREALLPDMARSYRLLLGGLGENPDRQGLIKTPERAAKAMLY 177
Query: 86 FTKGYDQSLEEVLNNAIFDEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILG 145
FTKGYDQSLE+VLN A+FDED DEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLP KILG
Sbjct: 178 FTKGYDQSLEDVLNGAVFDEDHDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPCNKILG 237
Query: 146 LSKLARIVEIFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSK 205
LSKLARIVEIFSRRLQVQERLTKQIA+AVTQAV+PAGVAVV+EGVHMCMVMRGVQKINSK
Sbjct: 238 LSKLARIVEIFSRRLQVQERLTKQIAVAVTQAVQPAGVAVVVEGVHMCMVMRGVQKINSK 297
Query: 206 TVTSTMLGVFRDDPKTREEFLNLVHSK 232
TVTSTMLGVFRDDPKTREEFLNLV+SK
Sbjct: 298 TVTSTMLGVFRDDPKTREEFLNLVNSK 324
>UniRef50_P30793 Cluster: GTP cyclohydrolase I; n=78; cellular
organisms|Rep: GTP cyclohydrolase I - Homo sapiens
(Human)
Length = 250
Score = 297 bits (730), Expect = 1e-79
Identities = 139/186 (74%), Positives = 164/186 (88%)
Query: 46 EALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDE 105
E LP++A +Y +L+ LGE+P+R GLLKTP RAA AM FFTKGY +++ +VLN+AIFDE
Sbjct: 65 ELNLPNLAAAYSSILSSLGENPQRQGLLKTPWRAASAMQFFTKGYQETISDVLNDAIFDE 124
Query: 106 DTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQER 165
D DEMV+VKDI+MFSMCEHHLVPF GKV IGYLP ++LGLSKLARIVEI+SRRLQVQER
Sbjct: 125 DHDEMVIVKDIDMFSMCEHHLVPFVGKVHIGYLPNKQVLGLSKLARIVEIYSRRLQVQER 184
Query: 166 LTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEF 225
LTKQIA+A+T+A+RPAGV VV+E HMCMVMRGVQK+NSKTVTSTMLGVFR+DPKTREEF
Sbjct: 185 LTKQIAVAITEALRPAGVGVVVEATHMCMVMRGVQKMNSKTVTSTMLGVFREDPKTREEF 244
Query: 226 LNLVHS 231
L L+ S
Sbjct: 245 LTLIRS 250
>UniRef50_Q19980 Cluster: GTP cyclohydrolase I; n=89; cellular
organisms|Rep: GTP cyclohydrolase I - Caenorhabditis
elegans
Length = 223
Score = 292 bits (716), Expect = 6e-78
Identities = 138/188 (73%), Positives = 160/188 (85%)
Query: 45 REALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFD 104
+E L M N+Y+ ++ +GED R GLLKTPERAAKAM+ FTKGYD L+E+LN A+FD
Sbjct: 36 KEDHLKSMCNAYQSIIQHVGEDINRQGLLKTPERAAKAMMAFTKGYDDQLDELLNEAVFD 95
Query: 105 EDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQE 164
ED DEMV+VKDIEMFS+CEHHLVPF GKV IGY+P K+LGLSKLARIVE+FSRRLQVQE
Sbjct: 96 EDHDEMVIVKDIEMFSLCEHHLVPFMGKVHIGYIPNKKVLGLSKLARIVEMFSRRLQVQE 155
Query: 165 RLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREE 224
RLTKQIA A+ QAV+P+GVAVVIE HMCMVMRGVQKIN+ T TS MLGVFRDDPKTREE
Sbjct: 156 RLTKQIATAMVQAVQPSGVAVVIEASHMCMVMRGVQKINASTTTSCMLGVFRDDPKTREE 215
Query: 225 FLNLVHSK 232
FLNL++ +
Sbjct: 216 FLNLINKR 223
>UniRef50_A6QSY1 Cluster: GTP cyclohydrolase I; n=3; cellular
organisms|Rep: GTP cyclohydrolase I - Ajellomyces
capsulatus NAm1
Length = 390
Score = 254 bits (623), Expect = 1e-66
Identities = 116/195 (59%), Positives = 154/195 (78%)
Query: 38 LDHRPPTREALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEV 97
L+ P E +AN+ R +L +GEDPER GLL TPER AKA+++FTKGY++++ ++
Sbjct: 196 LEATPEENEKRTQKLANAVRTVLECIGEDPEREGLLGTPERYAKALMYFTKGYEENVRDL 255
Query: 98 LNNAIFDEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFS 157
+N A+F ED DE+V+VKDIE+FS+CEHHLVPF GK+ IGY+P ++LGLSK AR+ E+FS
Sbjct: 256 VNGAVFHEDHDELVIVKDIEIFSLCEHHLVPFTGKMHIGYIPDRRVLGLSKFARLAEMFS 315
Query: 158 RRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRD 217
RRLQVQERLTKQ+A+A+++ ++P GVAVVIE H+CMVMRGVQK +S T TS MLG R
Sbjct: 316 RRLQVQERLTKQVALAISEVLKPRGVAVVIESSHLCMVMRGVQKTSSTTTTSCMLGCMRA 375
Query: 218 DPKTREEFLNLVHSK 232
KTREEFL+L++ K
Sbjct: 376 SAKTREEFLSLLNRK 390
>UniRef50_Q8YLL1 Cluster: GTP cyclohydrolase I 1; n=29;
Bacteria|Rep: GTP cyclohydrolase I 1 - Anabaena sp.
(strain PCC 7120)
Length = 235
Score = 250 bits (611), Expect = 3e-65
Identities = 119/197 (60%), Positives = 151/197 (76%), Gaps = 1/197 (0%)
Query: 33 HHDLELDHRPPTREALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQ 92
H+ E + P+ E + M + R +L G+GEDPER GLLKTP+R A+AM F T GY+Q
Sbjct: 33 HNGREPELHQPSEEDM-ESMMGAVRSILVGVGEDPEREGLLKTPKRVAEAMRFLTSGYNQ 91
Query: 93 SLEEVLNNAIFDEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARI 152
SLEE+LN A+FDE +EMV+V+DI FS+CEHH++PF G+ + Y+P K++GLSKLARI
Sbjct: 92 SLEELLNGAVFDEGHNEMVLVRDINFFSLCEHHMLPFMGRAHVAYIPNQKVVGLSKLARI 151
Query: 153 VEIFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTML 212
VE++SRRLQVQERLT+QIA AV + P GVAVV+E HMCMVMRGVQK S TVTS ML
Sbjct: 152 VEMYSRRLQVQERLTRQIAEAVQTILEPQGVAVVMEASHMCMVMRGVQKPGSWTVTSAML 211
Query: 213 GVFRDDPKTREEFLNLV 229
GVF+++ KTREEF NL+
Sbjct: 212 GVFQEEQKTREEFFNLI 228
>UniRef50_Q94465 Cluster: GTP cyclohydrolase I; n=2; Dictyostelium
discoideum|Rep: GTP cyclohydrolase I - Dictyostelium
discoideum (Slime mold)
Length = 232
Score = 243 bits (594), Expect = 3e-63
Identities = 112/184 (60%), Positives = 148/184 (80%)
Query: 48 LLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDT 107
+L M +S + LL+ LGEDP+R GLLKTP R +KA+LFFT+GY+QS++EV+ AIF+E+
Sbjct: 47 VLNTMQSSVKTLLSSLGEDPDREGLLKTPLRMSKALLFFTQGYEQSVDEVIGEAIFNENH 106
Query: 108 DEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLT 167
EMVVV+DI++FS+CEHH+VPF+GK IGY+P K+LGLSKLAR+ EIF+RRLQVQERLT
Sbjct: 107 HEMVVVRDIDIFSLCEHHMVPFHGKCHIGYIPDQKVLGLSKLARVAEIFARRLQVQERLT 166
Query: 168 KQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLN 227
+QIA A+ + P GVAVVI+ HMCMVMRGVQK + T TS++ G+F +D +TR EF +
Sbjct: 167 RQIAQAIQAHLNPMGVAVVIDASHMCMVMRGVQKPGASTATSSVCGIFEEDSRTRAEFFS 226
Query: 228 LVHS 231
L +S
Sbjct: 227 LFNS 230
>UniRef50_P51599 Cluster: GTP cyclohydrolase I; n=14;
Ascomycota|Rep: GTP cyclohydrolase I - Neurospora crassa
Length = 313
Score = 237 bits (580), Expect = 2e-61
Identities = 109/192 (56%), Positives = 144/192 (75%)
Query: 38 LDHRPPTREALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEV 97
L+ ++ L M + R LL +GEDP+R GLL TPER AKAMLF TKGY +++ ++
Sbjct: 118 LEETEAQKQERLDKMKGAVRTLLECIGEDPDREGLLATPERYAKAMLFLTKGYQENVRDI 177
Query: 98 LNNAIFDEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFS 157
+N AIF E +EMV+VKDIE+FSMCEHHLVPF GK+ IGY+P ++G+SKL RI E+F+
Sbjct: 178 VNGAIFQEGHNEMVIVKDIEVFSMCEHHLVPFTGKMHIGYIPSNAVIGISKLPRIAELFA 237
Query: 158 RRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRD 217
RRLQ+QERLTK++A A+ + ++P GVAVV+E H+CMVMRGVQK S T+TS +LG F
Sbjct: 238 RRLQIQERLTKEVANAIMEILKPQGVAVVMESSHLCMVMRGVQKTTSSTITSCVLGCFES 297
Query: 218 DPKTREEFLNLV 229
KTR EFL+L+
Sbjct: 298 REKTRLEFLSLI 309
>UniRef50_Q8KEA8 Cluster: GTP cyclohydrolase I; n=46; Bacteria|Rep:
GTP cyclohydrolase I - Chlorobium tepidum
Length = 224
Score = 231 bits (564), Expect = 1e-59
Identities = 107/184 (58%), Positives = 136/184 (73%)
Query: 46 EALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDE 105
E +L M ++ LL G+GEDPER GLL TPER AK++ F TKGY Q E++L A+F E
Sbjct: 38 EEVLGSMTDAVYSLLKGVGEDPEREGLLLTPERVAKSLRFLTKGYRQDPEQLLKKAVFTE 97
Query: 106 DTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQER 165
DEMV+VKDI+++SMCEHH++PF+GK + Y+P GKI+GLSK+ R+VE+F+RRLQVQER
Sbjct: 98 SYDEMVLVKDIDIYSMCEHHMLPFFGKAHVAYIPDGKIVGLSKIPRVVEVFARRLQVQER 157
Query: 166 LTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEF 225
LT+QI A+ + P GVAVVIE HMCMVMRGV+K N+ T TS M G F TR EF
Sbjct: 158 LTQQIRDAIQNVLNPRGVAVVIEATHMCMVMRGVEKQNAVTTTSAMSGDFMTSQSTRSEF 217
Query: 226 LNLV 229
L L+
Sbjct: 218 LRLI 221
>UniRef50_Q9RYB4 Cluster: GTP cyclohydrolase I; n=5; Bacteria|Rep:
GTP cyclohydrolase I - Deinococcus radiodurans
Length = 216
Score = 224 bits (548), Expect = 1e-57
Identities = 103/192 (53%), Positives = 139/192 (72%), Gaps = 4/192 (2%)
Query: 42 PPTREALLPDMANSYRLL----LTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEV 97
P + LPD N+ L L +GEDP+R GL +TP+R AKA + T+GY Q+L +V
Sbjct: 18 PSLKGVPLPDNPNNLEPLTREWLAAIGEDPDREGLQRTPQRVAKAWAYMTEGYGQTLAQV 77
Query: 98 LNNAIFDEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFS 157
+ +F + EMV+VKDIE +SMCEHH++PFYG+ + Y+P +ILGLSK ARIV+++S
Sbjct: 78 VGEGVFAAEGSEMVIVKDIEFYSMCEHHMLPFYGRAHVAYIPGTRILGLSKFARIVDLYS 137
Query: 158 RRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRD 217
RRLQVQER+T Q+A AV + + P GVAV++EG+H+CM MRGVQK NS T TS M G+FR
Sbjct: 138 RRLQVQERITTQVADAVEELLAPKGVAVLMEGIHLCMAMRGVQKQNSSTTTSAMRGLFRS 197
Query: 218 DPKTREEFLNLV 229
DP+TR EF++ V
Sbjct: 198 DPRTRAEFMSAV 209
>UniRef50_Q6F9M5 Cluster: GTP cyclohydrolase I; n=3; cellular
organisms|Rep: GTP cyclohydrolase I - Acinetobacter sp.
(strain ADP1)
Length = 197
Score = 217 bits (530), Expect = 2e-55
Identities = 104/181 (57%), Positives = 131/181 (72%)
Query: 49 LPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTD 108
L M SY +LT +GED R GL TP RAAKA F T GY +SLEEV NNA+F D
Sbjct: 13 LMSMQQSYANILTAVGEDLNRPGLKDTPIRAAKAFSFLTSGYGKSLEEVTNNAVFPSDNH 72
Query: 109 EMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTK 168
EMV+VK+IE +S+CEHHL+PFYG+V I YLP+G++LGLSK ARI E+F+RRLQ+QE LT+
Sbjct: 73 EMVLVKNIEFYSLCEHHLLPFYGRVHIAYLPEGQVLGLSKFARITEMFARRLQIQENLTQ 132
Query: 169 QIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNL 228
QIA AV + + GVAV+I+ HMCM+MRGV K S T T + +G F+ D + R EFL+
Sbjct: 133 QIAQAVEEVTKARGVAVMIDSAHMCMMMRGVGKQESTTRTVSFIGDFKTDKEARREFLSA 192
Query: 229 V 229
V
Sbjct: 193 V 193
>UniRef50_A5UR68 Cluster: GTP cyclohydrolase I; n=7; Bacteria|Rep:
GTP cyclohydrolase I - Roseiflexus sp. RS-1
Length = 226
Score = 217 bits (529), Expect = 3e-55
Identities = 101/177 (57%), Positives = 131/177 (74%)
Query: 50 PDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDE 109
P + ++ R++L +GE+PER GLLKTP R AK T GY + ++N+AIF DE
Sbjct: 44 PAIEDAVRVILKQIGENPEREGLLKTPSRVAKMYAELTAGYHIDPDALINDAIFSVSYDE 103
Query: 110 MVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQ 169
MV+VK+IE S+CEHH++PF G+V + Y+P GK++GLSK+ RIVE+F+RRLQVQER+T Q
Sbjct: 104 MVLVKNIEFASLCEHHMLPFMGRVHVAYIPNGKVVGLSKIPRIVEMFARRLQVQERMTVQ 163
Query: 170 IAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFL 226
IA + Q + P GVAVV EGVHMC VMRGV+K + VTS M GVFRDDPKTR EF+
Sbjct: 164 IADFINQRLEPLGVAVVAEGVHMCAVMRGVKKAGATMVTSAMRGVFRDDPKTRSEFM 220
>UniRef50_A5WE14 Cluster: GTP cyclohydrolase I; n=4;
Pseudomonadales|Rep: GTP cyclohydrolase I -
Psychrobacter sp. PRwf-1
Length = 201
Score = 200 bits (487), Expect = 3e-50
Identities = 92/170 (54%), Positives = 124/170 (72%)
Query: 56 YRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKD 115
Y L+ GED R GLL TP RAAKA + T+GY QSL EV NNA+F D E+V+V +
Sbjct: 23 YAKLIASTGEDLNRPGLLDTPTRAAKAFGYLTQGYHQSLTEVTNNAVFPTDNSELVLVHN 82
Query: 116 IEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVT 175
IE +S+CEHHL+PF+G +GYLP GK+LGLSK+ARI+++++RRLQ+QE L++Q+A A+
Sbjct: 83 IEFYSLCEHHLLPFHGVAHVGYLPDGKVLGLSKVARIIDMYARRLQIQESLSQQVAEAIM 142
Query: 176 QAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEF 225
+ + GVAVV++ HMCM+MRGV K S T T+ MLG F+ D + R EF
Sbjct: 143 EVTQCRGVAVVMDASHMCMMMRGVNKQLSSTRTTAMLGDFKTDMQARNEF 192
>UniRef50_Q4SEZ7 Cluster: Chromosome 1 SCAF14609, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 1
SCAF14609, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 263
Score = 195 bits (475), Expect = 9e-49
Identities = 91/134 (67%), Positives = 113/134 (84%)
Query: 52 MANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMV 111
M SY+ +LT LGED R GL +TP RAAKAM F TKGY++S++E+LN+AIFDE+ E+V
Sbjct: 39 MEKSYKDILTELGEDATREGLQRTPLRAAKAMQFLTKGYNESVKEILNDAIFDENHQEVV 98
Query: 112 VVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIA 171
+VKDIEMFS+CEHHLVPF+GK I YLP K++GLSKLARIVE++SRR QVQERLTKQIA
Sbjct: 99 IVKDIEMFSLCEHHLVPFFGKAHIAYLPNKKVVGLSKLARIVEVYSRRFQVQERLTKQIA 158
Query: 172 IAVTQAVRPAGVAV 185
A+++A+ PAGVAV
Sbjct: 159 SAISEALEPAGVAV 172
>UniRef50_Q2Q448 Cluster: GTP cyclohydrolase I; n=1; Toxoplasma
gondii|Rep: GTP cyclohydrolase I - Toxoplasma gondii
Length = 262
Score = 187 bits (455), Expect = 2e-46
Identities = 93/184 (50%), Positives = 125/184 (67%), Gaps = 11/184 (5%)
Query: 57 RLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFD-EDTDE------ 109
R++L +GED RAGL +TP+R A AM FF++GY ++V+ NA+F E+ E
Sbjct: 71 RMILRAMGEDVTRAGLRETPKRVAAAMEFFSRGYRADPKDVIRNALFSVEEGHEDGQYLA 130
Query: 110 ----MVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQER 165
MV V I++ S+CEHHL+PF+GK IGY+P +LG+SK ARI+EI+SRRLQ+QER
Sbjct: 131 GKQGMVTVGRIDISSLCEHHLLPFFGKCHIGYIPDKHVLGISKFARIMEIYSRRLQIQER 190
Query: 166 LTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEF 225
LT+QIA+AV + +P GVAV++E HMCM MRGV S T T LGVF DP R EF
Sbjct: 191 LTQQIALAVMKVAKPRGVAVLLECTHMCMAMRGVSSPGSVTTTKAFLGVFETDPALRSEF 250
Query: 226 LNLV 229
++ +
Sbjct: 251 MSSI 254
>UniRef50_Q2GYY2 Cluster: Putative uncharacterized protein; n=1;
Chaetomium globosum|Rep: Putative uncharacterized
protein - Chaetomium globosum (Soil fungus)
Length = 233
Score = 185 bits (450), Expect = 1e-45
Identities = 80/158 (50%), Positives = 117/158 (74%)
Query: 38 LDHRPPTREALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEV 97
++ P L + ++ R +L +GE+P+R G+L TPER AKAM+F T+GY Q++ E+
Sbjct: 76 IEESPEQSVKRLGKLGDAVRTMLECIGENPDRPGVLNTPERYAKAMMFLTQGYGQNIHEI 135
Query: 98 LNNAIFDEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFS 157
+NNAIF E EMV+VKDI++FS+CEHH++PF GK+ I Y+P ++G+SKL RI E+FS
Sbjct: 136 VNNAIFHEGHHEMVIVKDIDIFSICEHHMLPFIGKMHIAYIPYHSVIGISKLPRIAEMFS 195
Query: 158 RRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMV 195
RRLQ+QERLTK +A + + ++P GVAVV+E H+CM+
Sbjct: 196 RRLQIQERLTKDVANTIMEVLQPQGVAVVMEASHLCMI 233
>UniRef50_Q8G0L4 Cluster: GTP cyclohydrolase I; n=20; Bacteria|Rep:
GTP cyclohydrolase I - Brucella suis
Length = 213
Score = 183 bits (445), Expect = 4e-45
Identities = 88/177 (49%), Positives = 122/177 (68%), Gaps = 3/177 (1%)
Query: 57 RLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDT--DEMVVVK 114
R LL GEDP+R GLL+TP+R AKA GY +S EEVL F+E D+MV+VK
Sbjct: 38 RTLLLWAGEDPDREGLLETPKRVAKAYQELFGGYSESPEEVLGTT-FEEVAGYDDMVLVK 96
Query: 115 DIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAV 174
DI FS CEHH+VP GK + YLP+G+++GLSK+AR+V+IF+RRLQ QE +T QIA ++
Sbjct: 97 DISFFSHCEHHMVPIIGKAHVAYLPEGRVVGLSKIARVVDIFARRLQTQESITAQIADSM 156
Query: 175 TQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNLVHS 231
+ ++P GVAV+IE HMCM MR ++K S T+T+T G F++ + F+ L+ +
Sbjct: 157 QRILKPRGVAVMIEAEHMCMAMRSIRKQGSSTITTTFTGDFKEKADQQVRFMTLIRT 213
>UniRef50_Q8G3S1 Cluster: GTP cyclohydrolase I; n=4;
Bifidobacterium|Rep: GTP cyclohydrolase I -
Bifidobacterium longum
Length = 199
Score = 178 bits (434), Expect = 8e-44
Identities = 89/177 (50%), Positives = 126/177 (71%), Gaps = 3/177 (1%)
Query: 57 RLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKDI 116
RL L +GEDPER GL++TP+R A+A G S + L FD DTDE+V+VKDI
Sbjct: 25 RLFLKSIGEDPEREGLVETPDRIARACRELFTGLQASPADALEKH-FDVDTDELVLVKDI 83
Query: 117 EMFSMCEHHLVPFYGKVSIGYLP-QGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVT 175
E++S+CEHHL+PF+G +GY+P + ++GLSKLAR+VE+++RR QVQERLT+QIA A+
Sbjct: 84 ELYSVCEHHLLPFHGVAHVGYIPAKDGVMGLSKLARLVEVYARRPQVQERLTQQIADALV 143
Query: 176 QAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNLVHSK 232
+ GV VV E H+CM MRG++K +++TVTS + G+ R +P TR E ++L+ K
Sbjct: 144 EYAGARGVIVVTECEHLCMSMRGIKKSSARTVTSAVRGMLR-NPATRAEAMSLILDK 199
>UniRef50_A5EFZ1 Cluster: GTP cyclohydrolase I; n=6;
Proteobacteria|Rep: GTP cyclohydrolase I -
Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)
Length = 206
Score = 178 bits (433), Expect = 1e-43
Identities = 84/183 (45%), Positives = 126/183 (68%), Gaps = 3/183 (1%)
Query: 51 DMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDT--D 108
D+ ++ R +LT +GEDP R GL +TP R A+A + GYDQ+ EE L F+E D
Sbjct: 21 DVEDAIRTILTWIGEDPSREGLSETPARVARAYKSYFAGYDQNPEEYLRKT-FEETAGYD 79
Query: 109 EMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTK 168
EMV++++I S CEHH+ P G+ +GY+P+ +++G+SKLAR+VE ++ RLQ+QER+T
Sbjct: 80 EMVLLRNIPFQSHCEHHMAPIIGRAWVGYVPRSRVVGISKLARVVEAYASRLQIQERMTA 139
Query: 169 QIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNL 228
+IA + + ++P GVAVVI+ H C+ RGV+K TS MLG FR+DP +R+EFL +
Sbjct: 140 EIANIIDEVLQPQGVAVVIKAAHHCISSRGVKKHGVDLTTSRMLGCFRNDPMSRQEFLAM 199
Query: 229 VHS 231
V++
Sbjct: 200 VNA 202
>UniRef50_Q3WEZ6 Cluster: GTP cyclohydrolase I; n=7; Bacteria|Rep:
GTP cyclohydrolase I - Frankia sp. EAN1pec
Length = 257
Score = 177 bits (432), Expect = 1e-43
Identities = 91/180 (50%), Positives = 124/180 (68%), Gaps = 4/180 (2%)
Query: 52 MANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMV 111
+A + R LL G+GEDP+R GL KTP+R A+A +G + EVL +FDE DEMV
Sbjct: 76 VARAVRELLIGIGEDPDREGLRKTPDRVARAYQEAVEGLGRDPAEVLTT-VFDEGHDEMV 134
Query: 112 VVKDIEMFSMCEHHLVPFYGKVSIGYLP--QGKILGLSKLARIVEIFSRRLQVQERLTKQ 169
+V+DI+ S+CEHHLV F GK + Y+P +G+I GLSKLAR+V++++RR QVQERLT Q
Sbjct: 135 LVRDIDFSSLCEHHLVVFAGKAHVAYIPNEKGQITGLSKLARLVDLYARRPQVQERLTSQ 194
Query: 170 IAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNLV 229
+A A+ + P GV VV+E H+CM MRGV+K + TVTS + G F P TR E ++L+
Sbjct: 195 VADALVDVLDPRGVMVVVEAEHLCMSMRGVRKPGATTVTSAVRGQFL-SPATRSEGMSLI 253
>UniRef50_Q0CVT9 Cluster: GTP cyclohydrolase I; n=1; Aspergillus
terreus NIH2624|Rep: GTP cyclohydrolase I - Aspergillus
terreus (strain NIH 2624)
Length = 216
Score = 176 bits (429), Expect = 3e-43
Identities = 91/179 (50%), Positives = 120/179 (67%), Gaps = 20/179 (11%)
Query: 52 MANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMV 111
+A + R +L +GEDP R GL TPER AKAML+FTKGY +++ + N AIF ED ++
Sbjct: 56 IAKAVRTILECVGEDPGREGLRATPERYAKAMLYFTKGYSENIFDRANGAIFHEDYKGLI 115
Query: 112 VVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIA 171
V+ IGY+P G+ILGLSK+A + E+FSRRLQVQERLT+Q+A
Sbjct: 116 VMH--------------------IGYIPDGRILGLSKMAHLAEVFSRRLQVQERLTEQVA 155
Query: 172 IAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNLVH 230
IAV ++P GV VV+E H+CM+MRGVQK+ S T TS M+G + +PK REEFL L+H
Sbjct: 156 IAVFNVLKPQGVGVVMESSHLCMIMRGVQKVRSTTTTSYMVGSMQSNPKAREEFLTLLH 214
>UniRef50_Q9PC02 Cluster: GTP cyclohydrolase I; n=16; Bacteria|Rep:
GTP cyclohydrolase I - Xylella fastidiosa
Length = 203
Score = 176 bits (428), Expect = 4e-43
Identities = 88/195 (45%), Positives = 120/195 (61%), Gaps = 4/195 (2%)
Query: 38 LDHRPPTREALLPDMAN-SYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEE 96
+DH ++ A + R LL GEDP R GLL TP R +A + GY + +
Sbjct: 1 MDHSKQQNASITQAQAEEAVRTLLRWAGEDPTREGLLDTPRRVVEAYGDWFSGYREDPHD 60
Query: 97 VLNNAIFDEDT--DEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVE 154
L F+E + DE++V+++I S CEHH+ P GKV IGYLP GK++G+SKLAR+VE
Sbjct: 61 YLQRT-FEEISGYDELIVLRNITYESHCEHHMAPIIGKVHIGYLPNGKVVGISKLARVVE 119
Query: 155 IFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGV 214
++RR Q+QE++T QIA + + + P GV VVIEG H CM RG+ K VTS MLG
Sbjct: 120 SYARRFQIQEKMTAQIAACIQETLTPRGVGVVIEGAHACMTTRGIHKRGVSMVTSKMLGT 179
Query: 215 FRDDPKTREEFLNLV 229
FR+D +TR EFL +
Sbjct: 180 FREDARTRAEFLQFI 194
>UniRef50_P0C0C1 Cluster: GTP cyclohydrolase I; n=23; Bacteria|Rep:
GTP cyclohydrolase I - Streptococcus pyogenes
Length = 194
Score = 176 bits (428), Expect = 4e-43
Identities = 85/171 (49%), Positives = 117/171 (68%), Gaps = 2/171 (1%)
Query: 60 LTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKDIEMF 119
L +GE+P R GLL TP+R AK G + +E A+F E +++V+VKDI +
Sbjct: 22 LEAIGENPNREGLLDTPKRVAKMYAEMFAGLKKDPKEEFT-AVFTEHHEDVVIVKDISFY 80
Query: 120 SMCEHHLVPFYGKVSIGYLPQ-GKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQAV 178
SMCEHH VPFYGK I YLP G++ GLSKLAR VE+ S+R Q+QERLT QIA A+ +A+
Sbjct: 81 SMCEHHQVPFYGKAHIAYLPSDGRVTGLSKLARAVEVASKRPQLQERLTAQIADALVEAL 140
Query: 179 RPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNLV 229
P GV V++E HMCM MRG++K SKT+T+T G++++D R+E + L+
Sbjct: 141 HPTGVLVLVEAEHMCMTMRGIKKPGSKTITTTARGLYKEDRSERQEVMALM 191
>UniRef50_Q92QB4 Cluster: GTP cyclohydrolase I; n=49;
Proteobacteria|Rep: GTP cyclohydrolase I - Rhizobium
meliloti (Sinorhizobium meliloti)
Length = 204
Score = 175 bits (425), Expect = 1e-42
Identities = 88/191 (46%), Positives = 123/191 (64%), Gaps = 8/191 (4%)
Query: 41 RPPTREALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNN 100
RP +EA + R+LL GEDP R GL TP R AKA GYD E+VL
Sbjct: 16 RPTQKEA-----EEAVRVLLRWAGEDPAREGLKDTPSRVAKAYREIFGGYDLVAEDVLGR 70
Query: 101 AIFDEDT--DEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSR 158
F+E + D++V+ KDI +S CEHH+VP GK I YLP G++LGLSK+AR+V+I++R
Sbjct: 71 T-FEEVSGYDDIVLEKDIPFYSHCEHHMVPIIGKAHIAYLPNGRVLGLSKIARVVDIYAR 129
Query: 159 RLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDD 218
RLQ QE +T QIA A+ + + P GVAV+IE H+CM MRG++K + T+T+T G F+ +
Sbjct: 130 RLQTQEAMTAQIAKAIDETLMPRGVAVMIEAEHLCMAMRGIKKQGATTLTTTFTGAFKSE 189
Query: 219 PKTREEFLNLV 229
P + F+ ++
Sbjct: 190 PAEQVRFMTML 200
>UniRef50_A4G565 Cluster: GTP cyclohydrolase I; n=2;
Betaproteobacteria|Rep: GTP cyclohydrolase I -
Herminiimonas arsenicoxydans
Length = 215
Score = 174 bits (424), Expect = 1e-42
Identities = 88/182 (48%), Positives = 118/182 (64%), Gaps = 5/182 (2%)
Query: 54 NSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTD---EM 110
+ +R LL LGE+P R GL +TP+R KA +T GY Q E+L +F + + E+
Sbjct: 35 HDWRRLLIHLGENPNRQGLQETPKRVQKAWQQWTAGYAQDPAEILK--VFSDGAEQYKEL 92
Query: 111 VVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQI 170
++V+ I ++S CEHHL PF+G +IGY P GKI+GLSKL R+V+ ++RRLQVQERLT QI
Sbjct: 93 IIVRGIPVYSHCEHHLAPFFGTATIGYTPNGKIVGLSKLTRLVDCYARRLQVQERLTIQI 152
Query: 171 AIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNLVH 230
A + + V+P V VVI HMCM RG+Q +TVTS +LG R +P R EFL L
Sbjct: 153 AETLMEHVQPLSVGVVIRCRHMCMESRGIQTQGEETVTSALLGEMRSNPALRSEFLTLTR 212
Query: 231 SK 232
K
Sbjct: 213 EK 214
>UniRef50_A6SZ52 Cluster: GTP cyclohydrolase I; n=2; root|Rep: GTP
cyclohydrolase I - Janthinobacterium sp. (strain
Marseille) (Minibacterium massiliensis)
Length = 198
Score = 173 bits (421), Expect = 3e-42
Identities = 89/180 (49%), Positives = 119/180 (66%), Gaps = 5/180 (2%)
Query: 56 YRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFD---EDTDEMVV 112
+R LLT LGE+ +R GL +TP+R KA +T GYDQ E+L +F+ E +E++V
Sbjct: 20 WRRLLTHLGENADRQGLRETPQRVEKAWKHWTSGYDQDPAEILK--VFEDGAEQYNELIV 77
Query: 113 VKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAI 172
V+ I ++S CEHHL PF+G +IGY P GKI+GLSKL R+V+ F++RLQVQERLT QIA
Sbjct: 78 VRGIPVYSHCEHHLAPFFGTATIGYTPNGKIVGLSKLTRLVDCFAKRLQVQERLTIQIAD 137
Query: 173 AVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNLVHSK 232
+ + V+P V VVI HMCM RG++ +TVTS +LG R + R EFL L K
Sbjct: 138 TLMEHVQPLSVGVVIRCRHMCMESRGIRTPGEETVTSALLGEMRTNLGLRNEFLMLAREK 197
>UniRef50_Q89IW2 Cluster: GTP cyclohydrolase I; n=13; Bacteria|Rep:
GTP cyclohydrolase I - Bradyrhizobium japonicum
Length = 229
Score = 173 bits (420), Expect = 4e-42
Identities = 87/175 (49%), Positives = 115/175 (65%), Gaps = 3/175 (1%)
Query: 57 RLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDT--DEMVVVK 114
+ LL +GE+ ER GLL TP R +A +GY Q EVL+ F E D+ V+V+
Sbjct: 52 KTLLAYIGENTEREGLLDTPRRVVEAFDELYQGYHQCPAEVLDRT-FGETAGYDDFVLVR 110
Query: 115 DIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAV 174
DIE S CEHH++PFYGK I Y P +++GLSKLAR+ +IF+RRLQ QE LT QIA A+
Sbjct: 111 DIEFTSQCEHHMMPFYGKAHIAYTPVERVVGLSKLARLTDIFARRLQTQEHLTAQIAAAI 170
Query: 175 TQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNLV 229
+ ++P GVAV+IE H CM +RGV K + T TS G+FRD+P + FL+LV
Sbjct: 171 DEVLKPRGVAVLIEAEHTCMSVRGVAKHGASTFTSRFTGMFRDNPAEQARFLSLV 225
>UniRef50_Q5NN57 Cluster: GTP cyclohydrolase I; n=4;
Sphingomonadales|Rep: GTP cyclohydrolase I - Zymomonas
mobilis
Length = 220
Score = 172 bits (418), Expect = 7e-42
Identities = 84/204 (41%), Positives = 128/204 (62%), Gaps = 3/204 (1%)
Query: 28 ENCTFHHDLELDHRPPTREALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFT 87
+N T +L P + + ++ + R L+ G+DP+R GL+ TP+R AKA ++
Sbjct: 16 QNITMEEIQDLAVMRPDQVNVPEEIQEAIRSLIRWAGDDPDREGLIDTPKRVAKAWKYYC 75
Query: 88 KGYDQSLEEVLNNAIFDE--DTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILG 145
+GY + E L +F+E D++V++KDI +S CEHH+ P G I YLP K++G
Sbjct: 76 RGYREDPENHLKT-VFEEVGGYDDIVLLKDIPFYSHCEHHMAPIMGHAHIAYLPDKKVVG 134
Query: 146 LSKLARIVEIFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSK 205
LSKLAR+++ ++ RLQ+QERLT Q+A + +RP GVAVVI VH CM RGV+ N +
Sbjct: 135 LSKLARVLKGYAHRLQIQERLTAQVADCIWNNLRPRGVAVVISAVHSCMAARGVETPNVQ 194
Query: 206 TVTSTMLGVFRDDPKTREEFLNLV 229
TVT T+ G++ +DP+ + LNL+
Sbjct: 195 TVTKTLRGIYSEDPEQAKMILNLM 218
>UniRef50_O69531 Cluster: GTP cyclohydrolase I; n=98; Bacteria|Rep:
GTP cyclohydrolase I - Mycobacterium leprae
Length = 205
Score = 170 bits (414), Expect = 2e-41
Identities = 86/178 (48%), Positives = 118/178 (66%), Gaps = 3/178 (1%)
Query: 57 RLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKDI 116
R LL +GEDP+R GL TP R A+A G + VLN +FDE+ +E+V+VK+I
Sbjct: 29 RELLYAIGEDPDREGLADTPARVARACRELFSGLYTDPQTVLNT-MFDEEHNELVIVKEI 87
Query: 117 EMFSMCEHHLVPFYGKVSIGYLP--QGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAV 174
M+S CEHHLV F+G IGYLP G++ GLSK+AR+V+++++R QVQERLT QIA A+
Sbjct: 88 PMYSTCEHHLVSFHGVAHIGYLPGADGRVTGLSKIARLVDLYAKRPQVQERLTSQIADAL 147
Query: 175 TQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNLVHSK 232
+ P GV +V+E H+CM MRGV+K + T TS + G F+ D +R E L L+ K
Sbjct: 148 VSKLDPRGVIIVVEAEHLCMAMRGVRKPGAITTTSAVRGQFKTDAASRAEALGLILRK 205
>UniRef50_Q68WZ4 Cluster: GTP cyclohydrolase 1; n=25; Bacteria|Rep:
GTP cyclohydrolase 1 - Rickettsia typhi
Length = 190
Score = 169 bits (412), Expect = 4e-41
Identities = 83/188 (44%), Positives = 119/188 (63%), Gaps = 5/188 (2%)
Query: 43 PTREALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAI 102
PTRE + + R LL +GEDP R GLLKTP+R + + GY + ++E+LN
Sbjct: 4 PTRE----EAKEAVRTLLRFIGEDPTREGLLKTPDRVINSYMEIFSGYGKDVQEILNTKF 59
Query: 103 FDE-DTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQ 161
+D + +++ ++ I+ S CEHH++PF G V I Y+P I+G+SKLARIV IFSRRLQ
Sbjct: 60 YDTYNFQDLISLEGIKFTSFCEHHILPFNGTVHIAYIPDNCIIGVSKLARIVNIFSRRLQ 119
Query: 162 VQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKT 221
+QE++T QIA ++ ++++P GVA+ I H CM MRGV NS T G+F + K
Sbjct: 120 IQEKMTVQIAESIQESLKPLGVAIKISAFHSCMSMRGVMHDNSVMNTMYYTGIFAEQQKY 179
Query: 222 REEFLNLV 229
R EFLN +
Sbjct: 180 RHEFLNFI 187
>UniRef50_Q6NF93 Cluster: GTP cyclohydrolase I; n=8; Bacteria|Rep:
GTP cyclohydrolase I - Corynebacterium diphtheriae
Length = 190
Score = 167 bits (407), Expect = 2e-40
Identities = 86/177 (48%), Positives = 117/177 (66%), Gaps = 3/177 (1%)
Query: 57 RLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKDI 116
R LL +GEDP+R GL +TP R AKA G EVL F ED E+V+V+DI
Sbjct: 15 RELLIAVGEDPDREGLQETPARVAKAYAEMFAGLHTDPTEVLAKT-FSEDHREVVLVRDI 73
Query: 117 EMFSMCEHHLVPFYGKVSIGYLP--QGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAV 174
++S CEHHLVPF+GK IGY+P GK+ GLSKLAR+V+++++R QVQERLT Q+A A+
Sbjct: 74 PIYSTCEHHLVPFFGKAHIGYIPGESGKVTGLSKLARLVDLYAKRPQVQERLTTQVADAL 133
Query: 175 TQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNLVHS 231
++ V VVIE H+CM MRG++K + T TS + G F+ + +R E L+L+ S
Sbjct: 134 VDKLQAQAVIVVIECEHLCMAMRGIRKPGAVTTTSAVRGGFKTNAASRAEVLSLIRS 190
>UniRef50_A2U8J6 Cluster: GTP cyclohydrolase I; n=2; Bacillus|Rep:
GTP cyclohydrolase I - Bacillus coagulans 36D1
Length = 215
Score = 167 bits (405), Expect = 3e-40
Identities = 83/174 (47%), Positives = 112/174 (64%), Gaps = 1/174 (0%)
Query: 57 RLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAI-FDEDTDEMVVVKD 115
R L+ G+DP+R GL +TP R KA L +T+GY + + L D D E+V+VKD
Sbjct: 41 RSLIDLCGDDPDRDGLQETPYRVLKAFLEYTEGYREDPKLHLAKTFDVDHDHKELVLVKD 100
Query: 116 IEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVT 175
IE +S+CEHH PF+G + Y P KI GLSK+AR+V+ ++RR QVQERLTKQIA AV
Sbjct: 101 IEFYSICEHHFAPFFGVAHVAYFPNEKITGLSKIARMVDGYARRFQVQERLTKQIADAVE 160
Query: 176 QAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNLV 229
+ + P G VV+E HMCM RGV+K ++ T T + G+F R EFL+L+
Sbjct: 161 EVLEPQGTMVVLEAKHMCMCGRGVKKSDASTTTMSYRGIFEGRADLRAEFLSLL 214
>UniRef50_Q7VFG4 Cluster: GTP cyclohydrolase I; n=6;
Helicobacter|Rep: GTP cyclohydrolase I - Helicobacter
hepaticus
Length = 206
Score = 162 bits (393), Expect = 8e-39
Identities = 74/174 (42%), Positives = 113/174 (64%), Gaps = 1/174 (0%)
Query: 56 YRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKD 115
+ L +GE+P R GLL TP+R A A GY +S ++ L + D DEM+V+K
Sbjct: 32 FESLCQNVGENPTREGLLHTPKRIASAFSDMLNGYAKSPKQALGSVFEDGVCDEMIVLKK 91
Query: 116 IEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVT 175
+ +S+CEHHL+PF+G +SIGY+P K++G+S LAR+ E+F+ RLQ+QERLT QIA A+
Sbjct: 92 LHFYSICEHHLLPFFGHISIGYIPDKKLVGISGLARLTEVFTHRLQIQERLTAQIADALI 151
Query: 176 QAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNLV 229
++P G +V + H+C+ MR S +TS + G+F+ D +TR EF+ ++
Sbjct: 152 AELKPKGAMIVCQARHLCLEMRS-NVPQSHIITSALRGLFKKDSRTRAEFMQIL 204
>UniRef50_UPI0000DADB56 Cluster: hypothetical protein
RcanM_01000666; n=1; Rickettsia canadensis str.
McKiel|Rep: hypothetical protein RcanM_01000666 -
Rickettsia canadensis str. McKiel
Length = 222
Score = 161 bits (390), Expect = 2e-38
Identities = 81/191 (42%), Positives = 118/191 (61%), Gaps = 5/191 (2%)
Query: 43 PTREALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAI 102
P+RE + + R LL +GEDP R GLLKTP+R + + GY++ + E+L+
Sbjct: 36 PSRE----EAKEAVRTLLKFIGEDPNREGLLKTPDRVINSYMEIFSGYEKDVAEILSTKF 91
Query: 103 FDE-DTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQ 161
+D + + + + I S CEHH++PF G V I Y+P I+G+SKLARIV +F+RRLQ
Sbjct: 92 YDTCNFQDFISLDGIRFTSFCEHHMLPFNGTVHISYIPDNCIIGISKLARIVNVFARRLQ 151
Query: 162 VQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKT 221
+QE++T QIA +V ++P GVAV I +H CM +RGV + NS T G+F + K
Sbjct: 152 IQEKMTVQIAESVQDNLKPLGVAVRISALHSCMSIRGVIQDNSIMNTMHYTGIFAEQQKY 211
Query: 222 REEFLNLVHSK 232
R EFLNL ++
Sbjct: 212 RHEFLNLTATR 222
>UniRef50_A4QTK3 Cluster: Putative uncharacterized protein; n=1;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 216
Score = 158 bits (383), Expect = 1e-37
Identities = 80/178 (44%), Positives = 117/178 (65%), Gaps = 20/178 (11%)
Query: 52 MANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMV 111
+A + R ++ +GEDP R GL +TP R A+A+ FFT+GY +++ EV N+AIF D+ E+V
Sbjct: 53 IAAAAREIICAVGEDPAREGLAETPNRYAEALQFFTQGYSKNIHEVSNDAIFSIDSRELV 112
Query: 112 VVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIA 171
++ IGY+P G++LGLSKL RI E+++RRLQ+QERLTKQ+
Sbjct: 113 IMH--------------------IGYVPNGRVLGLSKLPRIAEVYARRLQIQERLTKQVG 152
Query: 172 IAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNLV 229
A+ + + P GVAVV+E HMCMVMRGVQK + T+T +M G+ +DD + +F L+
Sbjct: 153 EAINEVLSPLGVAVVLECTHMCMVMRGVQKTGTVTLTQSMTGLLKDDLNEQNKFYTLL 210
>UniRef50_A2BL58 Cluster: GTP cyclohydrolase I; n=2;
Thermoprotei|Rep: GTP cyclohydrolase I - Hyperthermus
butylicus (strain DSM 5456 / JCM 9403)
Length = 193
Score = 157 bits (381), Expect = 2e-37
Identities = 79/173 (45%), Positives = 110/173 (63%), Gaps = 6/173 (3%)
Query: 57 RLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKDI 116
R++L +GEDPER GL +TP R A +GYD + E F E TD +VVV I
Sbjct: 13 RMILEAIGEDPEREGLRETPRRVADMFEELLEGYDFTEEYTW----FTEATD-LVVVSGI 67
Query: 117 EMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQ 176
+S+CEHHL+PF+G + YLP+GK++GLSK+ RIV +SRRLQ+QER+TKQIA +++
Sbjct: 68 RFYSLCEHHLLPFFGVAHVAYLPRGKVIGLSKIVRIVNKYSRRLQIQERMTKQIADEISK 127
Query: 177 AVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNLV 229
A V V+ E VH+CM MRGV+ + TV + + G F D +EE ++
Sbjct: 128 ATGSPDVMVITEAVHLCMAMRGVRN-GAPTVVAAVRGEFERDQSLKEEVYRII 179
>UniRef50_A7QSC6 Cluster: Chromosome chr3 scaffold_158, whole genome
shotgun sequence; n=2; Vitis vinifera|Rep: Chromosome
chr3 scaffold_158, whole genome shotgun sequence - Vitis
vinifera (Grape)
Length = 214
Score = 153 bits (371), Expect = 4e-36
Identities = 80/204 (39%), Positives = 124/204 (60%), Gaps = 6/204 (2%)
Query: 33 HHDLELDHRPPTREALLPD---MANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKG 89
H +EL+ P+ + + ++LL GLGED R G+ KTP R AKA+ T+G
Sbjct: 8 HFSVELEDGVNVEVGFEPETLPIEEAVKVLLQGLGEDINREGIRKTPARVAKALCEGTRG 67
Query: 90 YDQSLEEVLNNAIFDEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQG-KILGLSK 148
Y Q ++++ A+F E +V+V+D+++FS CE L+PF K +GY+P G +++GLSK
Sbjct: 68 YRQKAKDIVQGALFPEAVGGLVIVRDLDLFSYCESCLLPFQVKCHVGYVPSGQQVVGLSK 127
Query: 149 LAR-IVEIFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTV 207
L+R IV + +LQVQERLT+Q++ V+ ++ V VV+E H CMV RG++K+ S T
Sbjct: 128 LSRSIVHFYGFKLQVQERLTRQVSETVS-SLLGGDVIVVVEASHSCMVSRGIEKLGSNTA 186
Query: 208 TSTMLGVFRDDPKTREEFLNLVHS 231
T +LG F D + FL + +
Sbjct: 187 TMALLGRFSTDAAAKNMFLQSIQN 210
>UniRef50_Q1IAJ6 Cluster: Putative GTP cyclohydrolase I; n=1;
Pseudomonas entomophila L48|Rep: Putative GTP
cyclohydrolase I - Pseudomonas entomophila (strain L48)
Length = 202
Score = 153 bits (370), Expect = 5e-36
Identities = 75/169 (44%), Positives = 106/169 (62%), Gaps = 3/169 (1%)
Query: 59 LLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTD--EMVVVKDI 116
+L LGED R GL +TPER K+M+ T GY Q VL F+E ++++++I
Sbjct: 19 ILEYLGEDTNRQGLHETPERFLKSMVAQTVGYSQDPYRVLEK-FFEEVAGYKNLIMLQNI 77
Query: 117 EMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQ 176
SMCEHHL P G ++GY+P G+++GLSKLAR+V+IF++RLQ+QERLT +I +A+ +
Sbjct: 78 HFESMCEHHLAPIVGNATVGYIPNGRVVGLSKLARVVDIFAKRLQIQERLTSEIGLALDE 137
Query: 177 AVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEF 225
+RP GV V+I H C+ RG K N+ T+ GV D R EF
Sbjct: 138 VLRPKGVGVIIRAKHNCLCTRGAYKPNANMTTTYFSGVLDSDAIKRGEF 186
>UniRef50_Q82Z12 Cluster: GTP cyclohydrolase I; n=1; Enterococcus
faecalis|Rep: GTP cyclohydrolase I - Enterococcus
faecalis (Streptococcus faecalis)
Length = 186
Score = 144 bits (350), Expect = 1e-33
Identities = 79/170 (46%), Positives = 108/170 (63%), Gaps = 5/170 (2%)
Query: 59 LLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDE-DTDEMVVVKDIE 117
+L +GED +RAGL+ TP+R AK G + E + +FD + EMV+VKDI
Sbjct: 16 ILEAVGEDTQRAGLIDTPKRVAKMYAEVFSGLTEP--EFDDYKLFDSLNEGEMVLVKDIA 73
Query: 118 MFSMCEHHLVPFYGKVSIGYLPQG-KILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQ 176
+SMCEHHL+PFYGKV + YLP+G K+LGLSKL R+VE ++R VQE LT IA + +
Sbjct: 74 FYSMCEHHLLPFYGKVHVAYLPEGGKVLGLSKLPRLVEHCAKRPTVQEDLTVTIARKLQE 133
Query: 177 AVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFL 226
+ G+AV IE HMCM MRGV+ S T T G+F++ + + +FL
Sbjct: 134 NIPVKGIAVAIEAEHMCMTMRGVKTPQSSTKTFQFTGLFKEQ-EWKNQFL 182
>UniRef50_A5Z385 Cluster: Putative uncharacterized protein; n=1;
Eubacterium ventriosum ATCC 27560|Rep: Putative
uncharacterized protein - Eubacterium ventriosum ATCC
27560
Length = 151
Score = 143 bits (346), Expect = 4e-33
Identities = 67/140 (47%), Positives = 97/140 (69%), Gaps = 1/140 (0%)
Query: 89 GYDQSLEEVLNNAIFDEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSK 148
G ++S +E L+ F D + +V+ KDI +S CEHHL+PFYGKV I Y+P GK++G+SK
Sbjct: 8 GMNRSPKEHLSKT-FTCDNENVVIEKDITFYSTCEHHLMPFYGKVHIAYIPNGKVVGISK 66
Query: 149 LARIVEIFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVT 208
LAR VE+++RRLQ+QE++T QIA A+ + + GV V+ + HMCM RG++K SKTVT
Sbjct: 67 LARTVEVYARRLQIQEQMTNQIAKALEKYLGAKGVLVMAQAEHMCMSARGIKKPGSKTVT 126
Query: 209 STMLGVFRDDPKTREEFLNL 228
GVF +D R + L++
Sbjct: 127 FASTGVFEEDRNLRSDVLSI 146
>UniRef50_A0RYT5 Cluster: GTP cyclohydrolase I; n=2;
Thermoprotei|Rep: GTP cyclohydrolase I - Cenarchaeum
symbiosum
Length = 189
Score = 142 bits (345), Expect = 5e-33
Identities = 78/177 (44%), Positives = 112/177 (63%), Gaps = 9/177 (5%)
Query: 57 RLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKDI 116
R L+ LGEDP R GL +TP R A+ GY+ E + F ED+D VV +DI
Sbjct: 11 RELIIELGEDPTREGLRETPARMARMYGEIFGGYESDAELSVQ---FSEDSDA-VVARDI 66
Query: 117 EMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAV-T 175
+S+CEHH++PF+G + I YLP GK+ G+SKL R+VE +SRRLQ+QERLT+ IA + +
Sbjct: 67 GFYSVCEHHMLPFFGSIHIAYLPDGKVFGVSKLVRLVEKYSRRLQIQERLTRNIADELSS 126
Query: 176 QAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNLVHSK 232
Q V+ GVAVV E H+CM MRGV+ +++ +S G ++ D RE + ++ +
Sbjct: 127 QGVK--GVAVVAEAEHLCMKMRGVRS-DARLTSSAFRGAYK-DADAREGVMAMIRGR 179
>UniRef50_Q88ST4 Cluster: GTP cyclohydrolase I; n=11;
Lactobacillales|Rep: GTP cyclohydrolase I -
Lactobacillus plantarum
Length = 189
Score = 140 bits (340), Expect = 2e-32
Identities = 77/180 (42%), Positives = 113/180 (62%), Gaps = 8/180 (4%)
Query: 54 NSYRLLLTGLGEDPERAGLLKTPERAAK--AMLFFTKGYDQSLEEVLNNAIFD-EDTDEM 110
++ R +L+ +GEDP+R GL++TP R A+ A +F TK + N +F E EM
Sbjct: 12 HAVREILSAVGEDPDRPGLVETPARVARMYAEVFATK----TAAPFDNYKLFKVEHPTEM 67
Query: 111 VVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGK-ILGLSKLARIVEIFSRRLQVQERLTKQ 169
V++KDI +SMCEHHL+PF+G V + Y+PQ + ++GLSK+ R+++ S++ VQERLT
Sbjct: 68 VLLKDIPFYSMCEHHLLPFFGTVQVAYVPQHEQVIGLSKIPRLIDYCSQQPNVQERLTVS 127
Query: 170 IAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNLV 229
IA + + + PAG+AV I HMCM MRGV K T +S G F+ D + EFL +
Sbjct: 128 IATELQRILDPAGIAVSITARHMCMEMRGVSKPGVHTESSYYSGQFKTDLDLKREFLQRI 187
>UniRef50_Q97D54 Cluster: GTP cyclohydrolase I; n=7;
Clostridium|Rep: GTP cyclohydrolase I - Clostridium
acetobutylicum
Length = 195
Score = 140 bits (339), Expect = 3e-32
Identities = 73/170 (42%), Positives = 108/170 (63%), Gaps = 8/170 (4%)
Query: 57 RLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLN--NAIFDEDT-----DE 109
R +L LG+DP+R GL +TP+R AK KG + S +++ N F+ED D
Sbjct: 13 RGILIALGDDPDREGLKETPKRVAKMYEEVFKGMEYSNDDIAEMFNKTFEEDLKESEEDN 72
Query: 110 MVVVKDIEMFSMCEHHLVPFYGK-VSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTK 168
+V+VKDIE+FS CEHHL Y V++ Y+P +++GLSK+ARI ++ SRRLQ+QER+ K
Sbjct: 73 IVLVKDIEIFSHCEHHLTLMYNMTVAVAYIPNKRLIGLSKIARIADMVSRRLQLQERIGK 132
Query: 169 QIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDD 218
IA + + +AV+I+G H CM RG++K + T T T+ G F++D
Sbjct: 133 DIAEIMEKVTASKDIAVIIKGEHGCMTSRGIKKPGALTTTMTLKGRFKND 182
>UniRef50_A1SM21 Cluster: GTP cyclohydrolase I precursor; n=7;
Actinomycetales|Rep: GTP cyclohydrolase I precursor -
Nocardioides sp. (strain BAA-499 / JS614)
Length = 219
Score = 139 bits (337), Expect = 5e-32
Identities = 77/174 (44%), Positives = 104/174 (59%), Gaps = 5/174 (2%)
Query: 59 LLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKDIEM 118
LL LG D E +++TP R A G D L N E DE+V+V +I +
Sbjct: 47 LLRALGLDIETDEMVETPRRLVAAYHELLTGPDVDLTTFPNT----EGYDELVLVANIPV 102
Query: 119 FSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQAV 178
S+CEHH++PF G +GYLP +ILGLSK AR+VE+ +RR Q QERLT ++A +T +
Sbjct: 103 RSVCEHHMLPFVGVAHVGYLPDERILGLSKFARLVELVARRPQTQERLTTEVADHLTTHL 162
Query: 179 RPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNLVHSK 232
+P GV VVIE H CM +RGV+ ++TVTS + G RD R EFL+L +
Sbjct: 163 QPRGVGVVIEAEHTCMSLRGVRAQGTRTVTSALRGTLRDH-AARAEFLSLAREQ 215
>UniRef50_Q8RH43 Cluster: GTP cyclohydrolase I; n=3; Fusobacterium
nucleatum|Rep: GTP cyclohydrolase I - Fusobacterium
nucleatum subsp. nucleatum
Length = 187
Score = 134 bits (325), Expect = 1e-30
Identities = 66/176 (37%), Positives = 109/176 (61%), Gaps = 1/176 (0%)
Query: 54 NSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVV 113
N++ ++ LG+ + L TP+R A + G D +EVL F+ +++E+++
Sbjct: 12 NAFFEVIEALGDVEYKEELKDTPKRIADSYKEIFYGIDIDPKEVLTKT-FEVNSNELIME 70
Query: 114 KDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIA 173
K+++ +SMCEHH +PF+G V I Y+P KI G + +++EI SRR Q+QERLT++IA
Sbjct: 71 KNMDFYSMCEHHFLPFFGTVCIAYVPNKKIFGFGDILKLIEILSRRPQLQERLTEEIAKY 130
Query: 174 VTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNLV 229
+ + + GV VV+E H+C+ MRG +K N+K +T++ GVF D + E L L+
Sbjct: 131 IYEILNCQGVYVVVEAKHLCVTMRGQKKENTKILTTSAKGVFETDSNKKLEVLTLL 186
>UniRef50_Q5HBC9 Cluster: GTP cyclohydrolase I; n=4; canis
group|Rep: GTP cyclohydrolase I - Ehrlichia ruminantium
(strain Welgevonden)
Length = 190
Score = 128 bits (310), Expect = 9e-29
Identities = 67/181 (37%), Positives = 104/181 (57%), Gaps = 2/181 (1%)
Query: 51 DMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIF-DEDTDE 109
++ ++ LL+ +G+D +R GL+ TP R A F GY Q + V+ ++ +E D
Sbjct: 11 EVEDAISLLIRWIGDDVDRPGLIGTPRRMLNAYKKFFIGY-QDISLVIGGSVLPNEGYDS 69
Query: 110 MVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQ 169
M+ KDI S CEHH++P GKV+IGY+P I + ++ R+V FS+RLQVQERLT
Sbjct: 70 MITFKDIGFVSYCEHHIIPMRGKVNIGYVPDKVIFTIGQVIRLVNYFSKRLQVQERLTVD 129
Query: 170 IAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNLV 229
IA ++ + GV VVI H C++ + TS LG+F+++ + R EF N +
Sbjct: 130 IAESINSYLVSKGVIVVINATHECVLCYEENNSDLLLQTSCALGIFQNNVELRREFFNSI 189
Query: 230 H 230
+
Sbjct: 190 N 190
>UniRef50_Q1Q0A8 Cluster: Strongly similar to GTP cyclohydrolase I;
n=1; Candidatus Kuenenia stuttgartiensis|Rep: Strongly
similar to GTP cyclohydrolase I - Candidatus Kuenenia
stuttgartiensis
Length = 212
Score = 128 bits (310), Expect = 9e-29
Identities = 70/172 (40%), Positives = 101/172 (58%), Gaps = 4/172 (2%)
Query: 59 LLTGLGEDPERAGLLKTPERAAKAMLFFTKGYD--QSLEEVLNNAIFDEDTDEM--VVVK 114
+ T LG + A +TP R A++ T+GYD L +V + ++
Sbjct: 35 IFTTLGLNLNTAATKETPHRFINALIESTEGYDGDPKLVKVFETECRGGPDCRLSQIIEG 94
Query: 115 DIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAV 174
I F++CEHH +PFYG V +GY+ I+GLSKL R+V +FSRR +VQER+ +QIA +
Sbjct: 95 PIRFFALCEHHCLPFYGVVYVGYISHEHIIGLSKLTRLVHLFSRRFEVQERIGQQIADTL 154
Query: 175 TQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFL 226
Q + P GVAV IE H+C+ MRGV++I+S + T+ G + DP R EFL
Sbjct: 155 NQLLLPHGVAVYIEAHHLCVEMRGVKEISSISRTTFWRGNYDGDPALRAEFL 206
>UniRef50_Q2JC68 Cluster: GTP cyclohydrolase I; n=1; Frankia sp.
CcI3|Rep: GTP cyclohydrolase I - Frankia sp. (strain
CcI3)
Length = 192
Score = 128 bits (309), Expect = 1e-28
Identities = 74/166 (44%), Positives = 99/166 (59%), Gaps = 5/166 (3%)
Query: 57 RLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKDI 116
R LL +GEDP R GL +TP R A+ F G+D E A + ++V V DI
Sbjct: 28 RQLLVEIGEDPGRDGLRETPARYARWWREFV-GFDPGNTET---AFEQVNHGQLVQVNDI 83
Query: 117 EMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQ 176
++S+CEHHL+PF+ +SI YL + K+LGLSK ARI + RLQVQERLT IA A+
Sbjct: 84 RVWSLCEHHLLPFWCDISIAYLAKDKLLGLSKFARIAHHHAHRLQVQERLTGAIADAIEA 143
Query: 177 AVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTR 222
VAV +G H+CM MRG++ + + T + GVF+DDP R
Sbjct: 144 LCGVPDVAVRAKGEHLCMTMRGIRSPATMS-TLVLRGVFKDDPHMR 188
>UniRef50_Q6MK87 Cluster: FolE protein; n=1; Bdellovibrio
bacteriovorus|Rep: FolE protein - Bdellovibrio
bacteriovorus
Length = 242
Score = 127 bits (306), Expect = 3e-28
Identities = 72/195 (36%), Positives = 108/195 (55%), Gaps = 3/195 (1%)
Query: 40 HRPPTREALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLN 99
H T E + + + ++ LG D + L +TP+R AK + G ++
Sbjct: 48 HNGLTNEEKIERITEKFTDIMNTLGLDLKDDSLRETPKRVAKMYVNEVFG-GLDPKKFPK 106
Query: 100 NAIFDE--DTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFS 157
+ D + D+M+VV+ I S CEHH +P G ++ Y+P K++GLSK+ RIV+ FS
Sbjct: 107 MTVIDNKMNYDQMIVVQSIGCLSFCEHHFLPIDGFATVAYIPNKKVIGLSKINRIVQYFS 166
Query: 158 RRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRD 217
RR QVQERLTKQIA + + +AV I H C++MRG++ +S T TS + G F+
Sbjct: 167 RRPQVQERLTKQIADCLQYILDTEHIAVHINAKHYCVMMRGIEDTSSTTSTSDLRGHFKS 226
Query: 218 DPKTREEFLNLVHSK 232
+TREEFL +K
Sbjct: 227 RMETREEFLEHCRTK 241
>UniRef50_Q5PAR5 Cluster: GTP cyclohydrolase; n=1; Anaplasma
marginale str. St. Maries|Rep: GTP cyclohydrolase -
Anaplasma marginale (strain St. Maries)
Length = 198
Score = 126 bits (304), Expect = 5e-28
Identities = 64/188 (34%), Positives = 107/188 (56%), Gaps = 2/188 (1%)
Query: 40 HRPPTREALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLN 99
H+ R+ D + +L+ + + P+ GL T R A +GY
Sbjct: 2 HKDLARKPSDKDAEEAIEVLIRWIDDSPDMEGLSLTAGRVLNAYKESFQGYALESSHDFR 61
Query: 100 NAIF-DEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSR 158
N++F +E +M++++ + S CEHH+ P G V+I Y+P+ ++G+ + R+V+IF++
Sbjct: 62 NSVFANEGYSDMILLRGVNFSSTCEHHMSPMAGVVNISYIPKATVIGVGTVVRVVDIFAK 121
Query: 159 RLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINS-KTVTSTMLGVFRD 217
RLQVQER+T QIA +++ ++PAGVAV+IE H C G + ++ K TS MLG F++
Sbjct: 122 RLQVQERMTVQIAQFLSELLKPAGVAVLIEAKHWCAKYLGGEAVSDLKLQTSCMLGEFQN 181
Query: 218 DPKTREEF 225
+ R EF
Sbjct: 182 NQNVRSEF 189
>UniRef50_Q2GK14 Cluster: GTP cyclohydrolase I; n=2; Anaplasma
phagocytophilum HZ|Rep: GTP cyclohydrolase I - Anaplasma
phagocytophilum (strain HZ)
Length = 202
Score = 126 bits (304), Expect = 5e-28
Identities = 70/181 (38%), Positives = 98/181 (54%), Gaps = 4/181 (2%)
Query: 49 LPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTD 108
+ + + R+++ +G+DP R GLLKTP R GY L + +D +
Sbjct: 14 IEEAEEAVRVIIRWMGDDPNREGLLKTPRRVLDYYKKSCSGYAPELLSHYSILPYDGSSS 73
Query: 109 EMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTK 168
EMV+VK+I S CEHHL P G I Y+P+ KILG+ +A IV FS+RLQ+QERLT
Sbjct: 74 EMVLVKNIGFSSNCEHHLSPICGVAHIAYMPKEKILGIGSIAHIVGCFSKRLQLQERLTN 133
Query: 169 QIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINS----KTVTSTMLGVFRDDPKTREE 224
Q+A + + + P GVAV++E H C+ + TS MLGVF + R E
Sbjct: 134 QVAEYLEKILDPHGVAVLLEAEHWCVECSNRDTASRDERLNVQTSQMLGVFEERCDLRNE 193
Query: 225 F 225
F
Sbjct: 194 F 194
>UniRef50_Q971G9 Cluster: GTP cyclohydrolase I; n=4;
Sulfolobaceae|Rep: GTP cyclohydrolase I - Sulfolobus
tokodaii
Length = 215
Score = 126 bits (303), Expect = 6e-28
Identities = 67/194 (34%), Positives = 114/194 (58%), Gaps = 7/194 (3%)
Query: 45 REALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEV----LNN 100
+E ++ ++A R +L LGE+P+R GL +TP R A+A+L T G ++ L+
Sbjct: 15 QEKMVEEIAKRIREILEILGENPDREGLRETPLRVARALLEMTSGLRTPQPQIKTFNLSE 74
Query: 101 AIFDEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYL--PQGKILGLSKLARIVEIFSR 158
E D++++VK+I S+CEHHL+P GKV + Y+ + K+ G SK+ RIV ++
Sbjct: 75 DGISEVEDQIILVKNIGFSSLCEHHLLPIIGKVHVAYIVGQERKVAGFSKIIRIVNYYAS 134
Query: 159 RLQVQERLTKQIAIAVTQA-VRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRD 217
R Q+QERL +QIA A+ + + P GV V+ + +HMC +RGV+ + ++ G+F++
Sbjct: 135 RPQIQERLVQQIADAIMNSDIHPKGVMVIGDALHMCAYVRGVKDREASLLSVATRGLFKN 194
Query: 218 DPKTREEFLNLVHS 231
+ R L+ +
Sbjct: 195 NVSLRNYVFRLLET 208
>UniRef50_Q8S3C2 Cluster: GTP cyclohydrolase I; n=7; core
eudicotyledons|Rep: GTP cyclohydrolase I - Arabidopsis
thaliana (Mouse-ear cress)
Length = 466
Score = 122 bits (294), Expect = 8e-27
Identities = 76/203 (37%), Positives = 118/203 (58%), Gaps = 24/203 (11%)
Query: 35 DLELDHRPPTREALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSL 94
+L +H+P T + ++ +LLL GL ED R G+ KTP R AKA+ T+GY Q +
Sbjct: 23 ELAFEHQPETLA-----IQDAVKLLLQGLHEDVNREGIKKTPFRVAKALREGTRGYKQKV 77
Query: 95 EEVLNNAIFDE-DTDE----------MVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQG-K 142
++ + +A+F E DE +VVV+D++ +S CE L+PF+ K IGY+P G +
Sbjct: 78 KDYVQSALFPEAGLDEGVGQAGGVGGLVVVRDLDHYSYCESCLLPFHVKCHIGYVPSGQR 137
Query: 143 ILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKI 202
+LGLSK +R+ ++F++RLQ +RL I A+ V+PAGVAVV+E H+ + +
Sbjct: 138 VLGLSKFSRVTDVFAKRLQDPQRLADDICSALQHWVKPAGVAVVLECSHIHFPSLDLDSL 197
Query: 203 N-------SKTVTSTMLGVFRDD 218
N K + S+ GVF D+
Sbjct: 198 NLSSHRGFVKLLVSSGSGVFEDE 220
Score = 119 bits (286), Expect = 7e-26
Identities = 73/188 (38%), Positives = 103/188 (54%), Gaps = 7/188 (3%)
Query: 50 PDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDE 109
P+M ++ +L LGEDP R L+ TP R K ML F + + N A + + E
Sbjct: 268 PEMVSAVVSILKSLGEDPLRKELIATPTRFLKWMLNFQRTNLEMKLNSFNPAKVNGEVKE 327
Query: 110 MVVVKDIEM--FSMCEHHLVPFYGKVSIGYL-PQGKI---LGLSKLARIVEIFSRRLQVQ 163
+ ++ M +SMCEHHL+PFYG V IGY +G +G S + IV + +LQVQ
Sbjct: 328 KRLHCELNMPFWSMCEHHLLPFYGVVHIGYFCAEGSNPNPVGSSLMKAIVHFYGFKLQVQ 387
Query: 164 ERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTRE 223
ER+T+QIA ++ V V VV E H CM+ RG++K S T T +LG F D R
Sbjct: 388 ERMTRQIAETLSPLVG-GDVIVVAEAGHTCMISRGIEKFGSSTATIAVLGRFSSDNSARA 446
Query: 224 EFLNLVHS 231
FL+ +H+
Sbjct: 447 MFLDKIHT 454
>UniRef50_Q8ZG15 Cluster: GTP cyclohydrolase I; n=129; root|Rep: GTP
cyclohydrolase I - Yersinia pestis
Length = 220
Score = 122 bits (294), Expect = 8e-27
Identities = 56/122 (45%), Positives = 82/122 (67%)
Query: 108 DEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLT 167
DEMV V+DI + S CEHH V GK ++ Y+P+ ++GLSK+ RIV+ F++R QVQERLT
Sbjct: 95 DEMVTVRDITLTSTCEHHFVTIDGKATVAYIPKDSVIGLSKINRIVQFFAQRPQVQERLT 154
Query: 168 KQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLN 227
+QI +A+ + VAV I+ VH C+ RG++ S T T+++ G+F+ TR+EFL
Sbjct: 155 QQILLALQTLLGTNNVAVSIDAVHYCVKARGIRDATSATTTTSLGGLFKSSQNTRQEFLR 214
Query: 228 LV 229
V
Sbjct: 215 AV 216
>UniRef50_Q1FI35 Cluster: GTP cyclohydrolase I; n=1; Clostridium
phytofermentans ISDg|Rep: GTP cyclohydrolase I -
Clostridium phytofermentans ISDg
Length = 194
Score = 121 bits (292), Expect = 1e-26
Identities = 64/169 (37%), Positives = 98/169 (57%), Gaps = 8/169 (4%)
Query: 59 LLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLN--NAIFDEDTDE-----MV 111
+L LGEDP R GL+ TP+R A G + ++++ N F+ED + +V
Sbjct: 15 ILIALGEDPLREGLIDTPKRVANMYEEVFLGIQYTNDDIVTMFNKCFEEDQNTFLANGIV 74
Query: 112 VVKDIEMFSMCEHHLVPFYGK-VSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQI 170
+KDIE FS CEHH+ Y ++IGY P K++G+SK+ARI ++ +RLQ+QER+ I
Sbjct: 75 WIKDIECFSFCEHHMTLIYDMHITIGYKPLHKVIGISKIARIADMVCKRLQIQERIASDI 134
Query: 171 AIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDP 219
+T+ + + IEG H CM RG+QK ++ T T G+F+ +P
Sbjct: 135 LEILTKITGSDDIFIKIEGKHGCMTSRGIQKPHATTCTILTSGIFQHNP 183
>UniRef50_A4CGT7 Cluster: GTP cyclohydrolase I; n=1; Robiginitalea
biformata HTCC2501|Rep: GTP cyclohydrolase I -
Robiginitalea biformata HTCC2501
Length = 176
Score = 121 bits (292), Expect = 1e-26
Identities = 67/170 (39%), Positives = 102/170 (60%), Gaps = 6/170 (3%)
Query: 60 LTGLGEDPERAGLLKTPERAAKAMLFFT-KGYDQSLEEVLNNAIFDE--DTDEMVVVKDI 116
+ LG D L TP R A+ + T +G S + + F++ T EM+VV DI
Sbjct: 1 MQALGMDLSDTSLADTPMRVARMYVNETFRGL--SAKNFPRISFFEKAPGTPEMIVVNDI 58
Query: 117 EMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQ 176
++S CEHH VPF+GKV + Y+P ++LGLSK+ R+V+ SR+ +QERLT++IA +++
Sbjct: 59 TLYSYCEHHFVPFFGKVHVAYIPGDRLLGLSKVNRVVDYLSRKPHLQERLTREIADTLSE 118
Query: 177 AVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFL 226
++ VAV +E H+C+ RGV+ S T T LG F+ + TR EF+
Sbjct: 119 LLQTRHVAVFVEAQHLCVASRGVRDAKSITRTGCYLGQFQ-NTHTRAEFM 167
>UniRef50_Q8T649 Cluster: GTP cyclohydrolase I; n=3; Plasmodium
yoelii|Rep: GTP cyclohydrolase I - Plasmodium yoelii
yoelii
Length = 315
Score = 120 bits (290), Expect = 2e-26
Identities = 57/139 (41%), Positives = 92/139 (66%), Gaps = 2/139 (1%)
Query: 72 LLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDED--TDEMVVVKDIEMFSMCEHHLVPF 129
L +T R AKA L+ T+GY S++ V+ +I+ + ++ +KDI ++S+C+HHL+PF
Sbjct: 142 LKRTNNRFAKAFLYLTEGYKMSVKNVIKKSIYKRKYKNNTLIKIKDIHVYSLCKHHLLPF 201
Query: 130 YGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEG 189
G I Y P I+GLSK +RI +I++RRLQ+QE LT I A+ + ++P + V I+
Sbjct: 202 EGLCDIEYNPDKYIMGLSKFSRITDIYARRLQLQEDLTNDICNALKKYLKPLYIKVTIKA 261
Query: 190 VHMCMVMRGVQKINSKTVT 208
H+C+ MRGV++ ++ TVT
Sbjct: 262 KHLCINMRGVKEHDAMTVT 280
>UniRef50_Q6SIF0 Cluster: GTP cyclohydrolase I; n=1; Plasmodium
knowlesi|Rep: GTP cyclohydrolase I - Plasmodium knowlesi
Length = 451
Score = 120 bits (289), Expect = 3e-26
Identities = 62/193 (32%), Positives = 115/193 (59%), Gaps = 4/193 (2%)
Query: 28 ENCTFHHDLELDHRPPTR-EALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFF 86
E C E + + T+ + + D++ S + +L + P + L KT R + L+
Sbjct: 231 EPCGIDTPRESNEKAGTKKDEQIADISRSIKKILRS-SKVPPKDILKKTGRRFSDTFLYL 289
Query: 87 TKGYDQSLEEVLNNAIFDED--TDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKIL 144
TKGY S+E+V+ +++ + + ++ + I ++S+C+HHL+PF G+ +I Y+P I+
Sbjct: 290 TKGYHMSVEKVIKKSLYKRNYKNNSVIKISGIHIYSLCKHHLLPFEGECTIEYIPNKYIM 349
Query: 145 GLSKLARIVEIFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINS 204
GLSK +R+++IF+RRLQ+QE LT I A+ + ++P + V + H+C+ MRGV++ ++
Sbjct: 350 GLSKFSRVIDIFARRLQLQEDLTNDICNALGKYLKPKYLHVNLVARHLCINMRGVKEHDA 409
Query: 205 KTVTSTMLGVFRD 217
T+T+ V D
Sbjct: 410 TTITNAYYEVKND 422
>UniRef50_O97071 Cluster: GTP cyclohydrolase I; n=6; Plasmodium|Rep:
GTP cyclohydrolase I - Plasmodium falciparum
Length = 389
Score = 119 bits (287), Expect = 5e-26
Identities = 55/150 (36%), Positives = 95/150 (63%), Gaps = 2/150 (1%)
Query: 72 LLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDE--DTDEMVVVKDIEMFSMCEHHLVPF 129
L +T R A+ L+ T GY+ +E+++ +++ + ++ V I ++S+C+HHL+PF
Sbjct: 225 LKRTNRRYAETFLYLTNGYNLDIEQIIKRSLYKRMYKNNSIIKVTGIHIYSLCKHHLLPF 284
Query: 130 YGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEG 189
G I Y+P I+GLSK +RIV++FSRRLQ+QE LT I A+ + ++P + V I
Sbjct: 285 EGTCDIEYIPNKYIIGLSKFSRIVDVFSRRLQLQEDLTNDICNALKKYLKPLYIKVSIVA 344
Query: 190 VHMCMVMRGVQKINSKTVTSTMLGVFRDDP 219
H+C+ MRGV++ ++KT+T +++P
Sbjct: 345 KHLCINMRGVKEHDAKTITYASYKAEKENP 374
>UniRef50_Q23AG3 Cluster: GTP cyclohydrolase I family protein; n=1;
Tetrahymena thermophila SB210|Rep: GTP cyclohydrolase I
family protein - Tetrahymena thermophila SB210
Length = 223
Score = 119 bits (286), Expect = 7e-26
Identities = 66/185 (35%), Positives = 99/185 (53%), Gaps = 1/185 (0%)
Query: 44 TREALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLF-FTKGYDQSLEEVLNNAI 102
+ E + + + +L L D + TP R AK + +G D + +
Sbjct: 34 SNEEKIKKIEECFTEILNMLSLDQTDDSICDTPSRVAKMYINEMFQGLDYANFPDMTTID 93
Query: 103 FDEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQV 162
+ +EMV ++DI + + CEHH + F G ++ Y+P+ K+LGLSK+ R+V FS+R QV
Sbjct: 94 NKMEYNEMVQIQDIALTTTCEHHFITFDGFATVAYIPKDKVLGLSKINRLVRFFSKRPQV 153
Query: 163 QERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTR 222
QERLTKQI +A+ V VAV I VH C+ RGV NS T T G F +D +
Sbjct: 154 QERLTKQILVALQTIVETEDVAVHINAVHFCVKARGVMDQNSSTATYAYGGKFLEDKDLK 213
Query: 223 EEFLN 227
++FL+
Sbjct: 214 KQFLD 218
>UniRef50_Q01A10 Cluster: GTP cyclohydrolase I; n=2;
Ostreococcus|Rep: GTP cyclohydrolase I - Ostreococcus
tauri
Length = 504
Score = 118 bits (284), Expect = 1e-25
Identities = 63/160 (39%), Positives = 93/160 (58%), Gaps = 18/160 (11%)
Query: 51 DMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDED---- 106
D++ R +L +GED ER GL+ TP R AKA+ F +GYD L A+F+ED
Sbjct: 56 DVSRCVREMLRAMGEDVEREGLMDTPARVAKALAFAMRGYDACPTAALGTALFNEDGLAR 115
Query: 107 -------------TDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQ-GKILGLSKLARI 152
T+++V+V+DI +FS C +PFYG + +GY P+ G I+GLSKLAR+
Sbjct: 116 ASSASTKEDVELGTNDVVLVRDIPVFSTCARTFMPFYGVIHVGYAPRAGVIVGLSKLARV 175
Query: 153 VEIFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHM 192
E++SRRLQ + L + +A A+ P GV V+ G+ +
Sbjct: 176 AEVYSRRLQTPDGLARAVAQALDDVASPLGVGVMFTGMQL 215
Score = 102 bits (245), Expect = 7e-21
Identities = 54/121 (44%), Positives = 70/121 (57%), Gaps = 2/121 (1%)
Query: 104 DEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYL--PQGKILGLSKLARIVEIFSRRLQ 161
DE D + V +D+ M ++CEHHL+PF+G VS Y+ P + L L IV SRRLQ
Sbjct: 371 DEIEDGVCVTRDLHMSTVCEHHLLPFHGTVSAAYMTGPGAQPLSRDTLQAIVSRHSRRLQ 430
Query: 162 VQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKT 221
VQERLT+ IA ++ GV V H+CMV RGV+K S T T+ LG F +P
Sbjct: 431 VQERLTRDIAEEISTLTGGVGVIVAARASHLCMVSRGVEKPGSSTCTAVKLGQFAREPAL 490
Query: 222 R 222
R
Sbjct: 491 R 491
>UniRef50_Q7XM20 Cluster: OSJNBa0084K01.11 protein; n=4; Oryza
sativa|Rep: OSJNBa0084K01.11 protein - Oryza sativa
subsp. japonica (Rice)
Length = 451
Score = 118 bits (283), Expect = 2e-25
Identities = 71/190 (37%), Positives = 106/190 (55%), Gaps = 12/190 (6%)
Query: 51 DMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTK-GYDQSLEE-VLNN-AIFD--- 104
+M ++ +L LGEDP R L+ TP+R + ++ F D L LNN +++
Sbjct: 255 NMVSAVSSMLLSLGEDPFRKELVGTPQRYVQWLMKFRACNLDVKLNGFTLNNLSVYQSPA 314
Query: 105 -EDTDEMVVVKDIEM--FSMCEHHLVPFYGKVSIGYLP--QGKILGLSKLARIVEIFSRR 159
+ D + ++ + + CEHHL+PFYG V IGYL G+++ S +V + +
Sbjct: 315 GDAADHRAIHSELHLPFCAQCEHHLLPFYGVVHIGYLDGGDGEVIDRSHFQALVHFYGCK 374
Query: 160 LQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDP 219
LQVQER+T+QIA AV +V G VV+E H+CM+ RG++KI S T T +LG F DP
Sbjct: 375 LQVQERMTRQIAEAV-YSVSHCGAIVVVEANHICMISRGIEKIRSSTATIAVLGQFLTDP 433
Query: 220 KTREEFLNLV 229
+ FL V
Sbjct: 434 SAKARFLQNV 443
Score = 61.3 bits (142), Expect = 2e-08
Identities = 35/106 (33%), Positives = 64/106 (60%), Gaps = 11/106 (10%)
Query: 88 KGYDQSLEEVLNNAIFDEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQG-KILGL 146
KGY Q + +++ A+F E V D S + + F+ +GY+P G +++GL
Sbjct: 67 KGYMQKVRDIVPVALFPE------VGVDQRTGSCWRNWSIQFH----VGYVPSGGRVVGL 116
Query: 147 SKLARIVEIFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHM 192
SKL+R+ ++F++RLQ +RL ++ A+ +++PAGVAV ++ H+
Sbjct: 117 SKLSRVADVFAKRLQNPQRLASEVCGALHASIQPAGVAVALQCWHI 162
>UniRef50_A5K040 Cluster: GTP cyclohydrolase I, putative; n=1;
Plasmodium vivax|Rep: GTP cyclohydrolase I, putative -
Plasmodium vivax
Length = 423
Score = 117 bits (282), Expect = 2e-25
Identities = 57/173 (32%), Positives = 104/173 (60%), Gaps = 3/173 (1%)
Query: 44 TREALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIF 103
++E + ++ S +L+ P+ L +T +R L+ TKGY ++ +V+ +++
Sbjct: 218 SKETQMEAISKSINHILSSSNVPPKDI-LKRTSKRFTDTFLYLTKGYHMNVGKVIKKSLY 276
Query: 104 DED--TDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQ 161
D + + I ++S+C+HHL+PF G+ SI Y+P ++GLSK +R++ IF+RRLQ
Sbjct: 277 KRKYKNDSRIKISGIHIYSLCKHHLLPFEGECSIEYVPNRYVMGLSKFSRVINIFARRLQ 336
Query: 162 VQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGV 214
+QE LT I A+ + ++P + V + H+C+ MRGV++ ++ TVT+ GV
Sbjct: 337 LQEDLTNDICNALRKYLKPKYIHVNVVARHLCINMRGVREHDATTVTNAYYGV 389
>UniRef50_Q5V5Y0 Cluster: GTP cyclohydrolase I; n=1; Haloarcula
marismortui|Rep: GTP cyclohydrolase I - Haloarcula
marismortui (Halobacterium marismortui)
Length = 210
Score = 113 bits (272), Expect = 4e-24
Identities = 63/167 (37%), Positives = 90/167 (53%), Gaps = 4/167 (2%)
Query: 57 RLLLTGLGEDPERAGLLKTPERAAKAML-FFTKGYDQSLEEVLNNAIFDEDTDEMVVVKD 115
RLLL G DP+ AGL T R M T+G + ++ FD +TD ++V
Sbjct: 32 RLLLEAAGRDPDSAGLSDTWSRRVPDMFETLTEGARSESKPIMRT--FDAETDGLIVKTG 89
Query: 116 IEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVT 175
I + SMCEHH++PF G + Y P +++GLSKL R V SR+L QE LT+ IA +
Sbjct: 90 IPLHSMCEHHMLPFRGVAHVAYRPGDQMVGLSKLIRYVRWQSRQLTTQETLTRDIAAGLA 149
Query: 176 QAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTR 222
+ GV V + HMC VMRG++ +KT T +G + +T+
Sbjct: 150 DELDAHGVVVELTATHMCEVMRGIE-TETKTTTREHVGTINEADRTQ 195
>UniRef50_Q6ME26 Cluster: Probable GTP cyclohydrolase I; n=1;
Candidatus Protochlamydia amoebophila UWE25|Rep:
Probable GTP cyclohydrolase I - Protochlamydia
amoebophila (strain UWE25)
Length = 224
Score = 111 bits (267), Expect = 1e-23
Identities = 63/185 (34%), Positives = 100/185 (54%), Gaps = 5/185 (2%)
Query: 52 MANSYRLLLTGLGEDPERAGLLKTPERAAKAML--FFTKGYDQSLEEV--LNNAIFDEDT 107
+A ++ ++ L D E L +TPER AK + F+ +++ E+ + I E
Sbjct: 38 IAEHFKAIMETLELDVEDESLARTPERVAKMYVNEIFSGLDEENFPEISFFKDEIHHEHK 97
Query: 108 DEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLT 167
MV VK + S CEHH VP G + Y+P +++GLSK+ R+V F++R Q+QERLT
Sbjct: 98 ANMVFVK-VGFTSFCEHHFVPMSGFAYVAYIPTNQLIGLSKIPRLVRYFAKRPQLQERLT 156
Query: 168 KQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLN 227
QIA ++ + VAV + +H C+ RG+Q S T+T+ + G F D R EF
Sbjct: 157 AQIADSLALLLNTEHVAVSLTAIHSCVQARGIQDECSHTITNVLRGQFGADGNLRREFFE 216
Query: 228 LVHSK 232
++ +
Sbjct: 217 GINRR 221
>UniRef50_UPI00015BB290 Cluster: GTP cyclohydrolase; n=1; Ignicoccus
hospitalis KIN4/I|Rep: GTP cyclohydrolase - Ignicoccus
hospitalis KIN4/I
Length = 186
Score = 109 bits (262), Expect = 6e-23
Identities = 60/172 (34%), Positives = 97/172 (56%), Gaps = 3/172 (1%)
Query: 60 LTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLN-NAIFDEDTDEMVVVKDIEM 118
L +GEDP R GL +TPER +A+ KG + E+ + ++++VVK++
Sbjct: 14 LEEMGEDPSRPGLSETPERYVRALRELFKGLETPKPELKTFKTEYLLGENDLIVVKNVSF 73
Query: 119 FSMCEHHLVPFYGKVSIGYLP-QGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQA 177
S+CEHHL+P G+ SI Y P + +++GLSK+ RIV+ ++R +QER T IA + +A
Sbjct: 74 SSLCEHHLLPILGRASIVYHPKRDEVIGLSKIPRIVKWLAKRPMLQERFTAMIADEIMKA 133
Query: 178 VRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNLV 229
GV V++ H C+ +RGV+ + + +T + G +P E LV
Sbjct: 134 -GARGVYVLVRAKHSCVAVRGVEDPDVEMITEAVRGTLEANPSLLERARKLV 184
>UniRef50_A3J0S0 Cluster: GTP cyclohydrolase I; n=28;
Bacteroidetes|Rep: GTP cyclohydrolase I - Flavobacteria
bacterium BAL38
Length = 249
Score = 109 bits (261), Expect = 8e-23
Identities = 63/180 (35%), Positives = 100/180 (55%), Gaps = 6/180 (3%)
Query: 56 YRLLLTGLGEDPERAGLLKTPERAAKAMLF-FTKGYDQSLEEVLNNAIFDEDT--DEMVV 112
+ +++ LG D L TP R AK + G + + + ++ +FD D+M+V
Sbjct: 73 FEIIMKELGLDLTDDSLQGTPHRVAKMFVQEIFSGLNPANKPKIS--VFDNSYQYDKMLV 130
Query: 113 VKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAI 172
+I S CEHH +P GK IGY+ GK++GLSKL RIV+ ++RR QVQER+ QI
Sbjct: 131 EANISFNSTCEHHFLPIVGKAHIGYVSSGKVIGLSKLNRIVDYYARRPQVQERMIMQIFN 190
Query: 173 AVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNLVHSK 232
+ + V VV+E H+C+ RG++ +S T T GVF + + R++F ++H +
Sbjct: 191 ELKTVLETDNVMVVMEATHLCVSSRGIKDESSYTSTLQYGGVF-NQKEFRDDFYKMIHKE 249
>UniRef50_A6RNT4 Cluster: Putative uncharacterized protein; n=2;
Sclerotiniaceae|Rep: Putative uncharacterized protein -
Botryotinia fuckeliana B05.10
Length = 1504
Score = 107 bits (258), Expect = 2e-22
Identities = 47/90 (52%), Positives = 67/90 (74%)
Query: 43 PTREALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAI 102
P +A ++A + R LL +GED R GL KTPER AKA+ FFT+GY + E++N AI
Sbjct: 90 PIPQASPTEIAATIRTLLCQIGEDTNRDGLKKTPERYAKALQFFTQGYKEKSNELINGAI 149
Query: 103 FDEDTDEMVVVKDIEMFSMCEHHLVPFYGK 132
F+EDT++MV+V I++FS+CEHH++PF+GK
Sbjct: 150 FNEDTEDMVIVSGIDVFSLCEHHMLPFFGK 179
>UniRef50_Q19Z80 Cluster: Gp6; n=4; root|Rep: Gp6 - Mycobacterium
phage Qyrzula
Length = 191
Score = 105 bits (251), Expect = 1e-21
Identities = 54/142 (38%), Positives = 81/142 (57%), Gaps = 2/142 (1%)
Query: 75 TPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKDIEMFSMCEHHLVPFYGKVS 134
TP R+AKA GY + + L D V++ +++ SMC HHL+PF G +
Sbjct: 29 TPLRSAKAWSDILSGYREDPADHLEVTFSAPDDPGQVILAGVQLQSMCAHHLLPFTGMAT 88
Query: 135 IGYLPQ--GKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHM 192
+ Y P +++GLSKL+R+V+ ++RRLQVQER+ A+ +RPAG V+I H
Sbjct: 89 VAYRPSPGDRVVGLSKLSRVVQGYARRLQVQERIGADTVDAIMARLRPAGAVVLITASHD 148
Query: 193 CMVMRGVQKINSKTVTSTMLGV 214
CM +RG Q+ +S T T G+
Sbjct: 149 CMRLRGAQEPHSATTTIASKGL 170
>UniRef50_Q8ZWW5 Cluster: GTP cyclohydrolase I; n=4;
Pyrobaculum|Rep: GTP cyclohydrolase I - Pyrobaculum
aerophilum
Length = 187
Score = 103 bits (246), Expect = 5e-21
Identities = 57/155 (36%), Positives = 90/155 (58%)
Query: 59 LLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKDIEM 118
LL LGED + G+L TP+R KAM T+G + EV+ + + VV+++I
Sbjct: 18 LLEYLGEDLTKPGVLNTPKRFVKAMEELTRGLREPPPEVVFFPLEYDVELGPVVIENIGA 77
Query: 119 FSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQAV 178
S+CEHHL+P ++S+ Y+P + GLSK+ R+V+ + R +QER T+ +A + + +
Sbjct: 78 VSLCEHHLLPILLRISVAYVPGDGVPGLSKVIRLVKWAAARPIMQERFTEWLADLLMEKL 137
Query: 179 RPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLG 213
R GV V + GVHMC +RGV+ + +T G
Sbjct: 138 RAKGVQVKVCGVHMCSFIRGVKDEHHNMITEARRG 172
>UniRef50_A4SVK2 Cluster: GTP cyclohydrolase I; n=20; Bacteria|Rep:
GTP cyclohydrolase I - Polynucleobacter sp. QLW-P1DMWA-1
Length = 262
Score = 101 bits (241), Expect = 2e-20
Identities = 64/210 (30%), Positives = 103/210 (49%), Gaps = 5/210 (2%)
Query: 28 ENCTFHHDLELDH--RPPTREALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLF 85
+N FH + + +P E L+ ++A + +L L D K R M
Sbjct: 53 QNARFHANDNISAFIKPGELEGLVDEVAEKMQAVLESLVIDTNSDHNTKNTSRRVAKMYV 112
Query: 86 FTKGYDQSLEE-VLNNAIFDEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLP--QGK 142
+ +E+ L +E+++V I + S C HHL P G++ IG LP +
Sbjct: 113 QEVFNGRYVEQPTLTKFPNVSRLNELMIVGPITIRSACSHHLCPIMGRIWIGVLPSKESA 172
Query: 143 ILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKI 202
++GLSK +R+ E R Q+QE ++A + + ++P GVA+V++ H CM RGV+
Sbjct: 173 LIGLSKYSRLTEWVMCRPQIQEEAVVELADMLEKKIKPIGVAIVMDADHFCMQWRGVKDR 232
Query: 203 NSKTVTSTMLGVFRDDPKTREEFLNLVHSK 232
+SK V S M G F D R EFL+L+ +
Sbjct: 233 DSKMVNSVMRGAFLKDSNLRREFLSLLDKR 262
>UniRef50_UPI000038E307 Cluster: hypothetical protein Faci_03001748;
n=1; Ferroplasma acidarmanus fer1|Rep: hypothetical
protein Faci_03001748 - Ferroplasma acidarmanus fer1
Length = 191
Score = 99.5 bits (237), Expect = 6e-20
Identities = 51/121 (42%), Positives = 77/121 (63%), Gaps = 4/121 (3%)
Query: 108 DEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQ--GKILGLSKLARIVEIFSRRLQVQER 165
+ MV+VK+I +SMC HHL+PF+G ++I YLP+ G I G+SKL R V + + Q+QE
Sbjct: 63 ESMVIVKNISFYSMCSHHLLPFFGNINIAYLPRPAGYIAGVSKLVRSVNKIASKPQLQEN 122
Query: 166 LTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEF 225
+T +I + + P V V +G HMCM+MRGV++ ++ VTS++ + D KT E
Sbjct: 123 MTSEIVNLLYDNLNPLFVMVTAKGQHMCMMMRGVKQESATMVTSSV--KYSDVVKTELES 180
Query: 226 L 226
L
Sbjct: 181 L 181
>UniRef50_A5GUC6 Cluster: GTP cyclohydrolase I; n=28;
Cyanobacteria|Rep: GTP cyclohydrolase I - Synechococcus
sp. (strain RCC307)
Length = 262
Score = 99.5 bits (237), Expect = 6e-20
Identities = 65/195 (33%), Positives = 96/195 (49%), Gaps = 6/195 (3%)
Query: 39 DH-RPPTREALLPDMANSYRLLLTGLGEDPERA-GLLKTPERAAKAMLFFTKGYDQSLEE 96
DH +P E L ++ + R LL L D ER +T ER AK ++ + + E
Sbjct: 62 DHLKPGELELLQQEVTDKVRDLLRSLVIDIERDHNTEETAERVAK--MYLQEVFKGRYLE 119
Query: 97 VLNNAIFD--EDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVE 154
A F ++ DE+ V I + S C HHLVP G IG P ++GLSK AR+ +
Sbjct: 120 QPKIASFPNVKNLDEIYTVGPITVRSACSHHLVPILGNCWIGIKPGSSVIGLSKFARVAD 179
Query: 155 IFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGV 214
R +QE +A + + P G+A++++ H CM RGV++ + V S + G
Sbjct: 180 WVFSRPHIQEEAVMILADEIERLCEPKGLAILVKAQHYCMKWRGVKEPQTSMVNSVVRGD 239
Query: 215 FRDDPKTREEFLNLV 229
FR DP + EF LV
Sbjct: 240 FRHDPSLKAEFFELV 254
>UniRef50_Q7N3C4 Cluster: Similarities with GTP cyclohydrolase I;
n=1; Photorhabdus luminescens subsp. laumondii|Rep:
Similarities with GTP cyclohydrolase I - Photorhabdus
luminescens subsp. laumondii
Length = 234
Score = 96.3 bits (229), Expect = 6e-19
Identities = 71/189 (37%), Positives = 98/189 (51%), Gaps = 10/189 (5%)
Query: 48 LLPDMANSYRLLLTGLGEDPERAGLLK-TPERAAKA-MLFFTKGYDQSLEEVLNNAIFDE 105
++ + A S+ LT LG D + K TP R AKA +L KG + + + F
Sbjct: 45 IIDEAAISFGEFLTALGVDWKNDPNSKDTPRRVAKAYVLDLWKGRYKPMGPITT---FPA 101
Query: 106 DTDEMVVVKD-IEMFSMCEHHLVPFYGKVSIGYLPQ--GKILGLSKLARIVEIFSRRLQV 162
D + +V I + SMC HH G V + Y+P G++LGLSKL RIVE F RR +
Sbjct: 102 DNYDGIVFDGWIALDSMCSHHHQAISGYVHVAYMPSQYGRVLGLSKLNRIVEHFGRRGLI 161
Query: 163 QERLTKQIAIAVTQAV-RPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRD-DPK 220
QERLT I AV Q R GVAV+++ H C+ RGV+ S+ T G F + D
Sbjct: 162 QERLTAAIHNAVNQVCERNQGVAVLVDASHNCVRCRGVRHQRSRMKTQMFSGAFAEADSP 221
Query: 221 TREEFLNLV 229
++EF L+
Sbjct: 222 AKQEFYELI 230
>UniRef50_Q8XZK8 Cluster: GTP cyclohydrolase I; n=29;
Betaproteobacteria|Rep: GTP cyclohydrolase I - Ralstonia
solanacearum (Pseudomonas solanacearum)
Length = 209
Score = 96.3 bits (229), Expect = 6e-19
Identities = 50/172 (29%), Positives = 90/172 (52%), Gaps = 2/172 (1%)
Query: 59 LLTGLGEDPERAGLLKTPERAAKA-MLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKDIE 117
LL G + + A KT +R + GYD E L + F++ +MV+++ I
Sbjct: 37 LLEASGIEIDTAHTGKTAQRVRELWQRRLLDGYDIDPAEALGHG-FEDPRRDMVIIRSIA 95
Query: 118 MFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQA 177
+ +C HHL+PF G + YLP G++ G ++AR+++ S R QE +T ++A A+
Sbjct: 96 VHGVCPHHLLPFRGVAHVAYLPDGRLHGFGRIARMIDAISHRYTYQEWVTNEVAHALVAH 155
Query: 178 VRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNLV 229
+ G A +IE +C++M ++ + + +T +G F + + R EFL +
Sbjct: 156 GQARGAACLIEAEQLCLLMGENRRGDERVITQCYVGEFEQNMQARTEFLRAI 207
>UniRef50_A7JLM6 Cluster: GTP cyclohydrolase I; n=11; Francisella
tularensis|Rep: GTP cyclohydrolase I - Francisella
tularensis subsp. novicida GA99-3548
Length = 207
Score = 87.8 bits (208), Expect = 2e-16
Identities = 57/169 (33%), Positives = 90/169 (53%), Gaps = 10/169 (5%)
Query: 52 MANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLE--EVLNNAIFDEDTDE 109
+ +YR +L LG + KTP R A+ FT+ L+ A+++ + +
Sbjct: 42 ITKAYRQILDALGLYTDE--FEKTPFRVAR---MFTQEIFNGLDYANFPACALYENEFNY 96
Query: 110 MVVV--KDIEMFSMCEHHLVPFYGKVSIGYLPQGK-ILGLSKLARIVEIFSRRLQVQERL 166
V+ K+I + S CEHH VPF G + ++P+ I+GL ++ I + FSRR Q+QER+
Sbjct: 97 TGVLTQKNITIMSFCEHHFVPFEGTAEVSFIPKNNNIIGLCRINSICDFFSRRPQIQERM 156
Query: 167 TKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVF 215
T QI + + V+V I+ H C+ +RGV NS+T T + GVF
Sbjct: 157 TAQIFETLKFILSTEDVSVKIKAKHACVSLRGVNNQNSQTYTQMVGGVF 205
>UniRef50_Q08SR8 Cluster: GTP cyclohydrolase I 2; n=2;
Cystobacterineae|Rep: GTP cyclohydrolase I 2 -
Stigmatella aurantiaca DW4/3-1
Length = 153
Score = 87.0 bits (206), Expect = 4e-16
Identities = 45/144 (31%), Positives = 74/144 (51%), Gaps = 2/144 (1%)
Query: 83 MLFFTKGYDQSLEEVLNNAIF--DEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQ 140
M F GY + EE + + EMVVV D+ SMC HHL+P+ G+ + Y+P
Sbjct: 1 MTEFLDGYALTPEEAIGTVYPAPPDSAGEMVVVTDLRFHSMCPHHLLPYEGRAHVAYVPG 60
Query: 141 GKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQ 200
++G +L+ +V+ F+ RL +QE L + +A A+ + + A ++E CM +RG Q
Sbjct: 61 KHVVGFGRLSTLVDCFAHRLILQEDLARHVASALARVLGSPATACILEAKQACMRLRGEQ 120
Query: 201 KINSKTVTSTMLGVFRDDPKTREE 224
+ ++ T G R + R E
Sbjct: 121 QRDAITHVEAYEGRLRKEGPLRRE 144
>UniRef50_A7HBJ5 Cluster: GTP cyclohydrolase I; n=2;
Anaeromyxobacter|Rep: GTP cyclohydrolase I -
Anaeromyxobacter sp. Fw109-5
Length = 219
Score = 85.8 bits (203), Expect = 8e-16
Identities = 58/180 (32%), Positives = 90/180 (50%), Gaps = 6/180 (3%)
Query: 53 ANSYRLLLTGLGEDPE-RAG--LLKTPERAAKAMLF-FTKGYDQSLEEVLNNAIFDEDTD 108
A + L LG P+ RA L T R A+A L GY + E+L +AI D
Sbjct: 24 AEAVERFLDALGLPPQVRASPDLQGTHRRVAQAWLEDLVDGYRRDPAEILADAIPSPSRD 83
Query: 109 EMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTK 168
+V V I S+C HHL+P G + YLP G+++G +L R+V+ + RL +QE L
Sbjct: 84 -LVAVTGIAFHSVCPHHLLPSRGVAHVAYLPGGRVVGFGQLVRLVDALAHRLVLQEDLAH 142
Query: 169 QIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNL 228
IA A+ + G A +++ +CM +RG ++ ++ LG +R+ FL+L
Sbjct: 143 GIADALVTHLGARGAACLLDAEQLCMTVRGEKRGAARAHADAWLGALARG-ASRQRFLDL 201
>UniRef50_Q2GDH9 Cluster: GTP cyclohydrolase I; n=1; Neorickettsia
sennetsu str. Miyayama|Rep: GTP cyclohydrolase I -
Neorickettsia sennetsu (strain Miyayama)
Length = 180
Score = 83.8 bits (198), Expect = 3e-15
Identities = 47/134 (35%), Positives = 70/134 (52%), Gaps = 2/134 (1%)
Query: 62 GLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDE-MVVVKDIEMFS 120
G+GE +R G K + GY S L + + D E ++V+K S
Sbjct: 16 GVGET-DRLGARGASHSFLKMFANYFSGYACSDFSSLVAKMENPDGGESLLVLKRTPFLS 74
Query: 121 MCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQAVRP 180
CEHH++P G +SIGY+P I L L R+V ++RLQ+QER+ QIA+A+ +++ P
Sbjct: 75 FCEHHVLPISGYISIGYIPDKSITSLGSLGRLVSACTKRLQLQERICAQIALAIEESLSP 134
Query: 181 AGVAVVIEGVHMCM 194
GV V H C+
Sbjct: 135 KGVIVYASAKHACV 148
>UniRef50_Q83FV8 Cluster: GTP cyclohydrolase I; n=2; Tropheryma
whipplei|Rep: GTP cyclohydrolase I - Tropheryma whipplei
(strain Twist) (Whipple's bacillus)
Length = 181
Score = 76.6 bits (180), Expect = 5e-13
Identities = 46/137 (33%), Positives = 74/137 (54%), Gaps = 3/137 (2%)
Query: 59 LLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKDIEM 118
LL+ LG+D R L +TP A+ + G + + + L + I + +V+++DI
Sbjct: 19 LLSALGQDVGR--LKETPSIASSGLESLISGSETNPADCLVDLIPNTQKG-IVILRDIPF 75
Query: 119 FSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQAV 178
S+CEHHL+PF G ++ Y P + GL L +V +RRL +QER+T QIA A+ +
Sbjct: 76 RSICEHHLLPFVGTANLLYEPGKFLAGLGNLTSLVRCAARRLSIQERVTDQIADAIYTGL 135
Query: 179 RPAGVAVVIEGVHMCMV 195
V V + H C++
Sbjct: 136 CARRVLVSLAARHTCIL 152
>UniRef50_UPI0000F1DBDC Cluster: PREDICTED: similar to GTP
cyclohydrolase I (form A; N-terminus), partial; n=1;
Danio rerio|Rep: PREDICTED: similar to GTP
cyclohydrolase I (form A; N-terminus), partial - Danio
rerio
Length = 115
Score = 65.7 bits (153), Expect = 9e-10
Identities = 30/49 (61%), Positives = 36/49 (73%)
Query: 46 EALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSL 94
E LP +A +Y +L GLGEDP+R GLLKTP RAA AM FFTKGY + +
Sbjct: 66 EMSLPSIAAAYTTILRGLGEDPQRQGLLKTPWRAATAMQFFTKGYQEKI 114
>UniRef50_A0YW77 Cluster: GTP cyclohydrolase I; n=1; Lyngbya sp.
PCC 8106|Rep: GTP cyclohydrolase I - Lyngbya sp. PCC
8106
Length = 62
Score = 38.7 bits (86), Expect = 0.12
Identities = 17/32 (53%), Positives = 22/32 (68%)
Query: 51 DMANSYRLLLTGLGEDPERAGLLKTPERAAKA 82
+M + R LL GLGE+P+R GL TP+R KA
Sbjct: 31 EMRQAVRTLLLGLGENPDREGLKDTPKRVVKA 62
>UniRef50_Q9WZP8 Cluster: NADPH-dependent 7-cyano-7-deazaguanine
reductase (EC 1.7.1.13) (7- cyano-7-carbaguanine
reductase) (PreQ(0) reductase); n=3; Thermotogaceae|Rep:
NADPH-dependent 7-cyano-7-deazaguanine reductase (EC
1.7.1.13) (7- cyano-7-carbaguanine reductase) (PreQ(0)
reductase) - Thermotoga maritima
Length = 137
Score = 38.3 bits (85), Expect = 0.16
Identities = 29/92 (31%), Positives = 42/92 (45%), Gaps = 2/92 (2%)
Query: 80 AKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLP 139
A+ +F KG+D + L FD DE + ++ E ++C +P G+V I Y P
Sbjct: 4 AEGRIFDFKGHDAIRTDFLEAIDFD-GKDEYIKIETDEFSAVCPFSGLPDIGRVIIEYYP 62
Query: 140 Q-GKILGLSKLARIVEIFSRRLQVQERLTKQI 170
GKI+ L L F QE TK+I
Sbjct: 63 DGGKIVELKSLKYYFVSFRNVGIYQEEATKRI 94
>UniRef50_Q4EE10 Cluster: GTP cyclohydrolase I; n=1; Listeria
monocytogenes str. 4b H7858|Rep: GTP cyclohydrolase I -
Listeria monocytogenes str. 4b H7858
Length = 86
Score = 34.3 bits (75), Expect = 2.6
Identities = 13/30 (43%), Positives = 23/30 (76%)
Query: 52 MANSYRLLLTGLGEDPERAGLLKTPERAAK 81
+A++ +++L +GE+PER GL+ TP R A+
Sbjct: 30 IADAVKVILEAVGENPEREGLIDTPMRVAR 59
>UniRef50_Q5FLA3 Cluster: Negative regulator genetic competence;
n=1; Lactobacillus acidophilus|Rep: Negative regulator
genetic competence - Lactobacillus acidophilus
Length = 246
Score = 33.9 bits (74), Expect = 3.5
Identities = 23/80 (28%), Positives = 34/80 (42%), Gaps = 5/80 (6%)
Query: 50 PDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDE 109
PD AN+ R +++GLG+D +T E FF L+ L+ D+D D
Sbjct: 80 PDEANNLRQMMSGLGDDDN-----QTQEEPDSRRSFFDLDPKDDLDAQLDQDDEDKDLDA 134
Query: 110 MVVVKDIEMFSMCEHHLVPF 129
DIE + + H F
Sbjct: 135 NEDASDIEYWKFQKRHAYSF 154
>UniRef50_Q9L4X2 Cluster: NysJ; n=3; Streptomyces|Rep: NysJ -
Streptomyces noursei
Length = 5435
Score = 33.1 bits (72), Expect = 6.1
Identities = 35/95 (36%), Positives = 43/95 (45%), Gaps = 6/95 (6%)
Query: 16 AKYTDFRQVGGHENCTFHHDLELDHRPPTREALLPDMANSYRLLLTGLGEDPERAGLLKT 75
A+ TD Q GG +C D P REA+ D RLLLT E ERAG+ T
Sbjct: 94 ARDTDVSQRGGFLDCIADFDPGFFGISP-REAVTMDPQQ--RLLLTTAWEAVERAGIDAT 150
Query: 76 PERAAKAMLFF-TKGYDQS--LEEVLNNAIFDEDT 107
RA + F T G D + L L++A D T
Sbjct: 151 TLRATRTGAFIGTNGQDYAYLLVRSLDDATGDVGT 185
>UniRef50_UPI00006A220F Cluster: UPI00006A220F related cluster; n=2;
Xenopus tropicalis|Rep: UPI00006A220F UniRef100 entry -
Xenopus tropicalis
Length = 529
Score = 32.7 bits (71), Expect = 8.0
Identities = 20/53 (37%), Positives = 27/53 (50%), Gaps = 4/53 (7%)
Query: 22 RQVGGHENCTFHHDLELDHRPPTREALLPDMANSYRLLLTGLGEDPERAGLLK 74
+++ + NC FH D LD P T E D Y L T LGE+ E+A +K
Sbjct: 196 KEIVSNFNCRFHGDFALDKNPVTFE----DAIKVYASLPTLLGENGEKAVPMK 244
>UniRef50_Q9F719 Cluster: NADPH-dependent 7-cyano-7-deazaguanine
reductase (EC 1.7.1.13) (7- cyano-7-carbaguanine
reductase) (PreQ(0) reductase); n=11; Bacteria|Rep:
NADPH-dependent 7-cyano-7-deazaguanine reductase (EC
1.7.1.13) (7- cyano-7-carbaguanine reductase) (PreQ(0)
reductase) - Chlorobium tepidum
Length = 117
Score = 32.7 bits (71), Expect = 8.0
Identities = 22/98 (22%), Positives = 43/98 (43%), Gaps = 2/98 (2%)
Query: 91 DQSLEEVLNNAIFDEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLA 150
++ + EV +N D D + + + E S+C +P +G +++ Y+P + L L
Sbjct: 2 NKEIIEVFDNTY--PDRDYTIEIINPEFTSVCPKTGLPDFGTITVNYVPDKSCIELKSLK 59
Query: 151 RIVEIFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIE 188
F E +T +I + +A +P + V E
Sbjct: 60 YYFLEFRNAGIFYENITNRILDDLVEACQPRRMTVKTE 97
>UniRef50_P41437 Cluster: Apoptosis inhibitor 3; n=2;
Nucleopolyhedrovirus|Rep: Apoptosis inhibitor 3 - Orgyia
pseudotsugata multicapsid polyhedrosis virus (OpMNPV)
Length = 268
Score = 32.7 bits (71), Expect = 8.0
Identities = 27/95 (28%), Positives = 40/95 (42%), Gaps = 4/95 (4%)
Query: 34 HDLELDHRPPTREALL-PDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQ 92
HD D PP R A P A L T E P GL + PE A+A F+T D+
Sbjct: 89 HDTPHDRAPPARSAAAHPQYATEAARLRT-FAEWPR--GLKQRPEELAEAGFFYTGQGDK 145
Query: 93 SLEEVLNNAIFDEDTDEMVVVKDIEMFSMCEHHLV 127
+ + + D + D+ + + CE+ L+
Sbjct: 146 TRCFCCDGGLKDWEPDDAPWQQHARWYDRCEYVLL 180
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.323 0.137 0.399
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 248,532,934
Number of Sequences: 1657284
Number of extensions: 9689736
Number of successful extensions: 21986
Number of sequences better than 10.0: 88
Number of HSP's better than 10.0 without gapping: 82
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 21824
Number of HSP's gapped (non-prelim): 95
length of query: 232
length of database: 575,637,011
effective HSP length: 98
effective length of query: 134
effective length of database: 413,223,179
effective search space: 55371905986
effective search space used: 55371905986
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (22.0 bits)
S2: 71 (32.7 bits)
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