Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001231-TA|BGIBMGA001231-PA|IPR004827|Basic-leucine
zipper (bZIP) transcription factor, IPR004878|Protein of unknown
function DUF270
(533 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
BC130432-1|AAI30433.1| 612|Homo sapiens otopetrin 1 protein. 64 2e-09
BC130430-1|AAI30431.1| 612|Homo sapiens otopetrin 1 protein. 64 2e-09
BC005187-1|AAH05187.1| 167|Homo sapiens ubiquitin-fold modifier... 34 1.1
AL590714-1|CAH72141.1| 167|Homo sapiens ubiquitin-fold modifier... 34 1.1
AF151884-1|AAD34121.1| 167|Homo sapiens CGI-126 protein protein. 34 1.1
AB154405-1|BAD15374.1| 167|Homo sapiens Ufm1-conjugating enzyme... 34 1.1
BC063302-1|AAH63302.1| 1278|Homo sapiens Niemann-Pick disease, t... 32 5.8
AF338230-1|AAK25791.1| 1278|Homo sapiens Niemann-Pick disease C1... 32 5.8
AF157379-1|AAD48006.1| 1278|Homo sapiens Niemann-Pick C1 protein... 32 5.8
AF002020-1|AAB63982.1| 1278|Homo sapiens Niemann-Pick C disease ... 32 5.8
AB209048-1|BAD92285.1| 1289|Homo sapiens Niemann-Pick disease, t... 32 5.8
BC033646-1|AAH33646.2| 437|Homo sapiens AUP1 protein protein. 31 7.7
BC001658-1|AAH01658.1| 373|Homo sapiens AUP1 protein protein. 31 7.7
AK023983-1|BAB14753.1| 373|Homo sapiens protein ( Homo sapiens ... 31 7.7
AF165515-1|AAF86645.1| 410|Homo sapiens ancient ubiquitous prot... 31 7.7
AF100754-1|AAD43018.1| 476|Homo sapiens ancient ubiquitous prot... 31 7.7
AF100753-1|AAD43017.1| 410|Homo sapiens ancient ubiquitous 46 k... 31 7.7
>BC130432-1|AAI30433.1| 612|Homo sapiens otopetrin 1 protein.
Length = 612
Score = 63.7 bits (148), Expect = 2e-09
Identities = 76/341 (22%), Positives = 155/341 (45%), Gaps = 28/341 (8%)
Query: 25 AVPEDESESMT--VALSAFYAKLLIVLGIALPVTSTIQNELYTNITSDIFTMYLYVISML 82
+VP+ +E ++ L F A LL++L A+ +++L +T+ + L+++
Sbjct: 52 SVPQKLAEMLSSQYGLIVFVAGLLLLLAWAVHAAGVSKSDLLCFLTALMLLQLLWML--W 109
Query: 83 FLAYTFYHLRMARRYKDDNVKRTRYGSFYLHIGVAGFGVGSIIYSCLQFGEYFDLSGDCQ 142
++ + H R+ R +K T G+ +L + F V ++I CL+ G + S +C
Sbjct: 110 YVGRSSAHRRLFR------LKDTHAGAGWLRGSITLFAVITVILGCLKIGYFIGFS-ECL 162
Query: 143 LTIVAVKPVLRILYLVAQTVFIFSYT-DVLDPMRGVVIDRFGLMHLIATNVCEWLNVVVQ 201
V PV ++ + Q F++ + D++ + ++RFG++H + TN+ W N V+
Sbjct: 163 SATEGVFPVTHSVHTLLQVYFLWGHAKDIIQSFK--TLERFGVIHSVFTNLLLWANGVLN 220
Query: 202 DTRDDIVDVAYDQPILFRYANISGHKQIDINDKLDNLTIEEI---VDYPKPLLSVFNNNR 258
+++ + + ++ I + NI+ +D + N T + + + L FN
Sbjct: 221 ESKHQL-NEHKERLITLGFGNIT--TVLDDHTPQCNCTPPTLCTAISHGIYYLYPFNIEY 277
Query: 259 TDIGSKPSKKSKAFKEIKQCCARVKSNNHFSVDCGS--AHKGLFMGIAVLAGTIVSLMLF 316
+ S + + K +V S+ H + S G +G+ VLA TI ++++
Sbjct: 278 QILAS-----TMLYVLWKNIGRKVDSHQHQKMQFKSDGVMVGAVLGLTVLAATIAVVVVY 332
Query: 317 -NGLFQKKQHVELALLQINIWETILFVLMTIASAACIQRMR 356
+ + K E AL+ ++ L +LM A A I+ R
Sbjct: 333 LIHIGRSKTKSESALIMFYLYAITLLMLMGAAGLAGIRIYR 373
Score = 37.1 bits (82), Expect = 0.15
Identities = 19/74 (25%), Positives = 38/74 (51%), Gaps = 2/74 (2%)
Query: 436 NGRQRPGRQLITFLLVGNFALWLLNRVKNGRAEF-HPLQMEFYGVWAWTLITHVSAPLLV 494
N +++ R + FL + N +LW+ R E+ + L+ +G W ++ +++ P +
Sbjct: 537 NAKRKVLRNIAAFLFLCNISLWIPPAF-GCRPEYDNGLEEIVFGFEPWIIVVNLAMPFSI 595
Query: 495 CYRFQATVCLYEVW 508
YR A L+EV+
Sbjct: 596 FYRMHAAASLFEVY 609
>BC130430-1|AAI30431.1| 612|Homo sapiens otopetrin 1 protein.
Length = 612
Score = 63.7 bits (148), Expect = 2e-09
Identities = 76/341 (22%), Positives = 155/341 (45%), Gaps = 28/341 (8%)
Query: 25 AVPEDESESMT--VALSAFYAKLLIVLGIALPVTSTIQNELYTNITSDIFTMYLYVISML 82
+VP+ +E ++ L F A LL++L A+ +++L +T+ + L+++
Sbjct: 52 SVPQKLAEMLSSQYGLIVFVAGLLLLLAWAVHAAGVSKSDLLCFLTALMLLQLLWML--W 109
Query: 83 FLAYTFYHLRMARRYKDDNVKRTRYGSFYLHIGVAGFGVGSIIYSCLQFGEYFDLSGDCQ 142
++ + H R+ R +K T G+ +L + F V ++I CL+ G + S +C
Sbjct: 110 YVGRSSAHRRLFR------LKDTHAGAGWLRGSITLFAVITVILGCLKIGYFIGFS-ECL 162
Query: 143 LTIVAVKPVLRILYLVAQTVFIFSYT-DVLDPMRGVVIDRFGLMHLIATNVCEWLNVVVQ 201
V PV ++ + Q F++ + D++ + ++RFG++H + TN+ W N V+
Sbjct: 163 SATEGVFPVTHSVHTLLQVYFLWGHAKDIIQSFK--TLERFGVIHSVFTNLLLWANGVLN 220
Query: 202 DTRDDIVDVAYDQPILFRYANISGHKQIDINDKLDNLTIEEI---VDYPKPLLSVFNNNR 258
+++ + + ++ I + NI+ +D + N T + + + L FN
Sbjct: 221 ESKHQL-NEHKERLITLGFGNIT--TVLDDHTPQCNCTPPTLCTAISHGIYYLYPFNIEY 277
Query: 259 TDIGSKPSKKSKAFKEIKQCCARVKSNNHFSVDCGS--AHKGLFMGIAVLAGTIVSLMLF 316
+ S + + K +V S+ H + S G +G+ VLA TI ++++
Sbjct: 278 QILAS-----TMLYVLWKNIGRKVDSHQHQKMQFKSDGVMVGAVLGLTVLAATIAVVVVY 332
Query: 317 -NGLFQKKQHVELALLQINIWETILFVLMTIASAACIQRMR 356
+ + K E AL+ ++ L +LM A A I+ R
Sbjct: 333 LIHIGRSKTKSESALIMFYLYAITLLMLMGAAGLAGIRIYR 373
Score = 37.1 bits (82), Expect = 0.15
Identities = 19/74 (25%), Positives = 38/74 (51%), Gaps = 2/74 (2%)
Query: 436 NGRQRPGRQLITFLLVGNFALWLLNRVKNGRAEF-HPLQMEFYGVWAWTLITHVSAPLLV 494
N +++ R + FL + N +LW+ R E+ + L+ +G W ++ +++ P +
Sbjct: 537 NAKRKVLRNIAAFLFLCNISLWIPPAF-GCRPEYDNGLEEIVFGFEPWIIVVNLAMPFSI 595
Query: 495 CYRFQATVCLYEVW 508
YR A L+EV+
Sbjct: 596 FYRMHAAASLFEVY 609
>BC005187-1|AAH05187.1| 167|Homo sapiens ubiquitin-fold modifier
conjugating enzyme 1 protein.
Length = 167
Score = 34.3 bits (75), Expect = 1.1
Identities = 25/93 (26%), Positives = 41/93 (44%), Gaps = 7/93 (7%)
Query: 115 GVAGFGVGSIIYSCLQFGEYFDLSGDCQLTIVAVKPVLRILYLVAQTVFIFS-----YTD 169
G FG I+ L++ FD+ D +T P + + L +T ++ TD
Sbjct: 62 GTRWFGKCWYIHDLLKYE--FDIEFDIPITCPTTAPEIAVPELDGKTAKMYRGGKICLTD 119
Query: 170 VLDPMRGVVIDRFGLMHLIATNVCEWLNVVVQD 202
P+ + +FGL HL+A + WL V + D
Sbjct: 120 HFKPLWARNVPKFGLAHLMALGLGPWLAVEIPD 152
>AL590714-1|CAH72141.1| 167|Homo sapiens ubiquitin-fold modifier
conjugating enzyme 1 protein.
Length = 167
Score = 34.3 bits (75), Expect = 1.1
Identities = 25/93 (26%), Positives = 41/93 (44%), Gaps = 7/93 (7%)
Query: 115 GVAGFGVGSIIYSCLQFGEYFDLSGDCQLTIVAVKPVLRILYLVAQTVFIFS-----YTD 169
G FG I+ L++ FD+ D +T P + + L +T ++ TD
Sbjct: 62 GTRWFGKCWYIHDLLKYE--FDIEFDIPITYPTTAPEIAVPELDGKTAKMYRGGKICLTD 119
Query: 170 VLDPMRGVVIDRFGLMHLIATNVCEWLNVVVQD 202
P+ + +FGL HL+A + WL V + D
Sbjct: 120 HFKPLWARNVPKFGLAHLMALGLGPWLAVEIPD 152
>AF151884-1|AAD34121.1| 167|Homo sapiens CGI-126 protein protein.
Length = 167
Score = 34.3 bits (75), Expect = 1.1
Identities = 25/93 (26%), Positives = 41/93 (44%), Gaps = 7/93 (7%)
Query: 115 GVAGFGVGSIIYSCLQFGEYFDLSGDCQLTIVAVKPVLRILYLVAQTVFIFS-----YTD 169
G FG I+ L++ FD+ D +T P + + L +T ++ TD
Sbjct: 62 GTRWFGKCWYIHDLLKYE--FDIEFDIPITYPTTAPEIAVPELDGKTAKMYRGGKICLTD 119
Query: 170 VLDPMRGVVIDRFGLMHLIATNVCEWLNVVVQD 202
P+ + +FGL HL+A + WL V + D
Sbjct: 120 HFKPLWARNVPKFGLAHLMALGLGPWLAVEIPD 152
>AB154405-1|BAD15374.1| 167|Homo sapiens Ufm1-conjugating enzyme 1
protein.
Length = 167
Score = 34.3 bits (75), Expect = 1.1
Identities = 25/93 (26%), Positives = 41/93 (44%), Gaps = 7/93 (7%)
Query: 115 GVAGFGVGSIIYSCLQFGEYFDLSGDCQLTIVAVKPVLRILYLVAQTVFIFS-----YTD 169
G FG I+ L++ FD+ D +T P + + L +T ++ TD
Sbjct: 62 GTRWFGKCWYIHDLLKYE--FDIEFDIPITYPTTAPEIAVPELDGKTAKMYRGGKICLTD 119
Query: 170 VLDPMRGVVIDRFGLMHLIATNVCEWLNVVVQD 202
P+ + +FGL HL+A + WL V + D
Sbjct: 120 HFKPLWARNVPKFGLAHLMALGLGPWLAVEIPD 152
>BC063302-1|AAH63302.1| 1278|Homo sapiens Niemann-Pick disease, type
C1 protein.
Length = 1278
Score = 31.9 bits (69), Expect = 5.8
Identities = 28/117 (23%), Positives = 53/117 (45%), Gaps = 12/117 (10%)
Query: 49 LGIALPVTSTIQNELYTNITSDIFTMYL-YVISMLFLAYTFYHLRMARRYKDDNVKRTRY 107
L I+ +I++EL SD+FT+ + Y I L+++ H++ RR D+
Sbjct: 599 LTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHIKSCRRLLVDS------ 652
Query: 108 GSFYLHIGVAGFGVGSIIYSCLQFGEYFDLSGDCQLTIVAVKPVLRILYLVAQTVFI 164
+ +G+AG + +C G + + L ++ V P L +L + +FI
Sbjct: 653 ---KVSLGIAGILIVLSSVAC-SLGVFSYIGLPLTLIVIEVIPFL-VLAVGVDNIFI 704
>AF338230-1|AAK25791.1| 1278|Homo sapiens Niemann-Pick disease C1
protein protein.
Length = 1278
Score = 31.9 bits (69), Expect = 5.8
Identities = 28/117 (23%), Positives = 53/117 (45%), Gaps = 12/117 (10%)
Query: 49 LGIALPVTSTIQNELYTNITSDIFTMYL-YVISMLFLAYTFYHLRMARRYKDDNVKRTRY 107
L I+ +I++EL SD+FT+ + Y I L+++ H++ RR D+
Sbjct: 599 LTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHIKSCRRLLVDS------ 652
Query: 108 GSFYLHIGVAGFGVGSIIYSCLQFGEYFDLSGDCQLTIVAVKPVLRILYLVAQTVFI 164
+ +G+AG + +C G + + L ++ V P L +L + +FI
Sbjct: 653 ---KVSLGIAGILIVLSSVAC-SLGVFSYIGLPLTLIVIEVIPFL-VLAVGVDNIFI 704
>AF157379-1|AAD48006.1| 1278|Homo sapiens Niemann-Pick C1 protein
protein.
Length = 1278
Score = 31.9 bits (69), Expect = 5.8
Identities = 28/117 (23%), Positives = 53/117 (45%), Gaps = 12/117 (10%)
Query: 49 LGIALPVTSTIQNELYTNITSDIFTMYL-YVISMLFLAYTFYHLRMARRYKDDNVKRTRY 107
L I+ +I++EL SD+FT+ + Y I L+++ H++ RR D+
Sbjct: 599 LTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHIKSCRRLLVDS------ 652
Query: 108 GSFYLHIGVAGFGVGSIIYSCLQFGEYFDLSGDCQLTIVAVKPVLRILYLVAQTVFI 164
+ +G+AG + +C G + + L ++ V P L +L + +FI
Sbjct: 653 ---KVSLGIAGILIVLSSVAC-SLGVFSYIGLPLTLIVIEVIPFL-VLAVGVDNIFI 704
>AF002020-1|AAB63982.1| 1278|Homo sapiens Niemann-Pick C disease
protein protein.
Length = 1278
Score = 31.9 bits (69), Expect = 5.8
Identities = 28/117 (23%), Positives = 53/117 (45%), Gaps = 12/117 (10%)
Query: 49 LGIALPVTSTIQNELYTNITSDIFTMYL-YVISMLFLAYTFYHLRMARRYKDDNVKRTRY 107
L I+ +I++EL SD+FT+ + Y I L+++ H++ RR D+
Sbjct: 599 LTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHIKSCRRLLVDS------ 652
Query: 108 GSFYLHIGVAGFGVGSIIYSCLQFGEYFDLSGDCQLTIVAVKPVLRILYLVAQTVFI 164
+ +G+AG + +C G + + L ++ V P L +L + +FI
Sbjct: 653 ---KVSLGIAGILIVLSSVAC-SLGVFSYIGLPLTLIVIEVIPFL-VLAVGVDNIFI 704
>AB209048-1|BAD92285.1| 1289|Homo sapiens Niemann-Pick disease, type
C1 variant protein.
Length = 1289
Score = 31.9 bits (69), Expect = 5.8
Identities = 28/117 (23%), Positives = 53/117 (45%), Gaps = 12/117 (10%)
Query: 49 LGIALPVTSTIQNELYTNITSDIFTMYL-YVISMLFLAYTFYHLRMARRYKDDNVKRTRY 107
L I+ +I++EL SD+FT+ + Y I L+++ H++ RR D+
Sbjct: 610 LTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLLVDS------ 663
Query: 108 GSFYLHIGVAGFGVGSIIYSCLQFGEYFDLSGDCQLTIVAVKPVLRILYLVAQTVFI 164
+ +G+AG + +C G + + L ++ V P L +L + +FI
Sbjct: 664 ---KVSLGIAGILIVLSSVAC-SLGVFSYIGLPLTLIVIEVIPFL-VLAVGVDNIFI 715
>BC033646-1|AAH33646.2| 437|Homo sapiens AUP1 protein protein.
Length = 437
Score = 31.5 bits (68), Expect = 7.7
Identities = 20/74 (27%), Positives = 35/74 (47%), Gaps = 1/74 (1%)
Query: 22 PLLAVPEDESESMTVALSAFYAKLLIVLGIALPVTSTIQNELYTNITSDIFTMYLYVISM 81
PLL PE+E+ + L F + + + P+T +Q L + SD + ++
Sbjct: 182 PLLLFPEEEATNGREGLLRFSSWPFSIQDVVQPLTLQVQRPLVSVTVSDA-SWVSELLWS 240
Query: 82 LFLAYTFYHLRMAR 95
LF+ +T Y +R R
Sbjct: 241 LFVPFTVYQVRWLR 254
>BC001658-1|AAH01658.1| 373|Homo sapiens AUP1 protein protein.
Length = 373
Score = 31.5 bits (68), Expect = 7.7
Identities = 20/74 (27%), Positives = 35/74 (47%), Gaps = 1/74 (1%)
Query: 22 PLLAVPEDESESMTVALSAFYAKLLIVLGIALPVTSTIQNELYTNITSDIFTMYLYVISM 81
PLL PE+E+ + L F + + + P+T +Q L + SD + ++
Sbjct: 155 PLLLFPEEEATNGREGLLRFSSWPFSIQDVVQPLTLQVQRPLVSVTVSDA-SWVSELLWS 213
Query: 82 LFLAYTFYHLRMAR 95
LF+ +T Y +R R
Sbjct: 214 LFVPFTVYQVRWLR 227
>AK023983-1|BAB14753.1| 373|Homo sapiens protein ( Homo sapiens
cDNA FLJ13921 fis, clone Y79AA1000469, highly similar to
Mus musculus ancient ubiquitous 46 kDa protein AUP1
precursor ).
Length = 373
Score = 31.5 bits (68), Expect = 7.7
Identities = 20/74 (27%), Positives = 35/74 (47%), Gaps = 1/74 (1%)
Query: 22 PLLAVPEDESESMTVALSAFYAKLLIVLGIALPVTSTIQNELYTNITSDIFTMYLYVISM 81
PLL PE+E+ + L F + + + P+T +Q L + SD + ++
Sbjct: 155 PLLLFPEEEATNGREGLLRFSSWPFSIQDVVQPLTLQVQRPLVSVTVSDA-SWVSELLWS 213
Query: 82 LFLAYTFYHLRMAR 95
LF+ +T Y +R R
Sbjct: 214 LFVPFTVYQVRWLR 227
>AF165515-1|AAF86645.1| 410|Homo sapiens ancient ubiquitous protein
1 precursor protein.
Length = 410
Score = 31.5 bits (68), Expect = 7.7
Identities = 20/74 (27%), Positives = 35/74 (47%), Gaps = 1/74 (1%)
Query: 22 PLLAVPEDESESMTVALSAFYAKLLIVLGIALPVTSTIQNELYTNITSDIFTMYLYVISM 81
PLL PE+E+ + L F + + + P+T +Q L + SD + ++
Sbjct: 155 PLLLFPEEEATNGREGLLRFSSWPFSIQDVVQPLTLQVQRPLVSVTVSDA-SWVSELLWS 213
Query: 82 LFLAYTFYHLRMAR 95
LF+ +T Y +R R
Sbjct: 214 LFVPFTVYQVRWLR 227
>AF100754-1|AAD43018.1| 476|Homo sapiens ancient ubiquitous protein
AUP1 isoform protein.
Length = 476
Score = 31.5 bits (68), Expect = 7.7
Identities = 20/74 (27%), Positives = 35/74 (47%), Gaps = 1/74 (1%)
Query: 22 PLLAVPEDESESMTVALSAFYAKLLIVLGIALPVTSTIQNELYTNITSDIFTMYLYVISM 81
PLL PE+E+ + L F + + + P+T +Q L + SD + ++
Sbjct: 221 PLLLFPEEEATNGREGLLRFSSWPFSIQDVVQPLTLQVQRPLVSVTVSDA-SWVSELLWS 279
Query: 82 LFLAYTFYHLRMAR 95
LF+ +T Y +R R
Sbjct: 280 LFVPFTVYQVRWLR 293
>AF100753-1|AAD43017.1| 410|Homo sapiens ancient ubiquitous 46 kDa
protein AUP1 protein.
Length = 410
Score = 31.5 bits (68), Expect = 7.7
Identities = 20/74 (27%), Positives = 35/74 (47%), Gaps = 1/74 (1%)
Query: 22 PLLAVPEDESESMTVALSAFYAKLLIVLGIALPVTSTIQNELYTNITSDIFTMYLYVISM 81
PLL PE+E+ + L F + + + P+T +Q L + SD + ++
Sbjct: 155 PLLLFPEEEATNGREGLLRFSSWPFSIQDVVQPLTLQVQRPLVSVTVSDA-SWVSELLWS 213
Query: 82 LFLAYTFYHLRMAR 95
LF+ +T Y +R R
Sbjct: 214 LFVPFTVYQVRWLR 227
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.325 0.138 0.418
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 75,034,843
Number of Sequences: 224733
Number of extensions: 3076146
Number of successful extensions: 12608
Number of sequences better than 10.0: 17
Number of HSP's better than 10.0 without gapping: 0
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 12606
Number of HSP's gapped (non-prelim): 19
length of query: 533
length of database: 73,234,838
effective HSP length: 93
effective length of query: 440
effective length of database: 52,334,669
effective search space: 23027254360
effective search space used: 23027254360
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 40 (21.6 bits)
S2: 68 (31.5 bits)
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