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Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= BGIBMGA001228-TA|BGIBMGA001228-PA|IPR004878|Protein of unknown
function DUF270
         (448 letters)

Database: human 
           224,733 sequences; 73,234,838 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

BC130432-1|AAI30433.1|  612|Homo sapiens otopetrin 1 protein.          48   7e-05
BC130430-1|AAI30431.1|  612|Homo sapiens otopetrin 1 protein.          48   7e-05
BC035556-1|AAH35556.1|  538|Homo sapiens dolichol kinase protein.      31   6.3  
AY727913-1|AAV51404.1| 2472|Homo sapiens RIF1 isoform 4 protein.       31   6.3  
AY727912-1|AAV51403.1| 2446|Homo sapiens RIF1 protein.                 31   6.3  
AY727911-1|AAV51402.1| 2446|Homo sapiens RIF1 protein.                 31   6.3  
AY727910-1|AAV51401.1| 2446|Homo sapiens RIF1 protein.                 31   6.3  
AY585745-1|AAT40745.1| 2472|Homo sapiens Rap1 interacting factor...    31   6.3  
AY584066-1|AAS94233.1| 2472|Homo sapiens telomeric protein RIF1 ...    31   6.3  
AY358759-1|AAQ89119.1|  538|Homo sapiens TREC2422 protein.             31   6.3  
AL672142-7|CAI10844.1|  538|Homo sapiens transmembrane protein 1...    31   6.3  
AK024033-1|BAB14792.1|  719|Homo sapiens protein ( Homo sapiens ...    31   6.3  
AK022932-1|BAB14313.1|  838|Homo sapiens protein ( Homo sapiens ...    31   6.3  
AK001461-1|BAA91705.1|  852|Homo sapiens protein ( Homo sapiens ...    31   6.3  
AB029017-1|BAA83046.2|  544|Homo sapiens KIAA1094 protein protein.     31   6.3  

>BC130432-1|AAI30433.1|  612|Homo sapiens otopetrin 1 protein.
          Length = 612

 Score = 48.0 bits (109), Expect = 7e-05
 Identities = 25/104 (24%), Positives = 58/104 (55%), Gaps = 8/104 (7%)

Query: 43  HSGSFYLKLGAAGFALGHLIHSVLLLAVQIGHFLDEDVNNDDCVNILQVVLDVMFPLYCF 102
           H+G+ +L+     FA    + +V+L  ++IG+F    +   +C++  + V  V   ++  
Sbjct: 127 HAGAGWLRGSITLFA----VITVILGCLKIGYF----IGFSECLSATEGVFPVTHSVHTL 178

Query: 103 VQLYFIFKYSNVIILRYQNLARFAFMHMIGSSLCFWVSAIVRET 146
           +Q+YF++ ++  II  ++ L RF  +H + ++L  W + ++ E+
Sbjct: 179 LQVYFLWGHAKDIIQSFKTLERFGVIHSVFTNLLLWANGVLNES 222



 Score = 36.7 bits (81), Expect = 0.17
 Identities = 14/66 (21%), Positives = 32/66 (48%)

Query: 373 RELLMFLLIANVGMWLLYTFSYKSPESLDERYAFYGKVLWSILGHVSLPLIMFYRFHSSV 432
           R +  FL + N+ +W+   F  +           +G   W I+ ++++P  +FYR H++ 
Sbjct: 544 RNIAAFLFLCNISLWIPPAFGCRPEYDNGLEEIVFGFEPWIIVVNLAMPFSIFYRMHAAA 603

Query: 433 CFADIW 438
              +++
Sbjct: 604 SLFEVY 609


>BC130430-1|AAI30431.1|  612|Homo sapiens otopetrin 1 protein.
          Length = 612

 Score = 48.0 bits (109), Expect = 7e-05
 Identities = 25/104 (24%), Positives = 58/104 (55%), Gaps = 8/104 (7%)

Query: 43  HSGSFYLKLGAAGFALGHLIHSVLLLAVQIGHFLDEDVNNDDCVNILQVVLDVMFPLYCF 102
           H+G+ +L+     FA    + +V+L  ++IG+F    +   +C++  + V  V   ++  
Sbjct: 127 HAGAGWLRGSITLFA----VITVILGCLKIGYF----IGFSECLSATEGVFPVTHSVHTL 178

Query: 103 VQLYFIFKYSNVIILRYQNLARFAFMHMIGSSLCFWVSAIVRET 146
           +Q+YF++ ++  II  ++ L RF  +H + ++L  W + ++ E+
Sbjct: 179 LQVYFLWGHAKDIIQSFKTLERFGVIHSVFTNLLLWANGVLNES 222



 Score = 36.7 bits (81), Expect = 0.17
 Identities = 14/66 (21%), Positives = 32/66 (48%)

Query: 373 RELLMFLLIANVGMWLLYTFSYKSPESLDERYAFYGKVLWSILGHVSLPLIMFYRFHSSV 432
           R +  FL + N+ +W+   F  +           +G   W I+ ++++P  +FYR H++ 
Sbjct: 544 RNIAAFLFLCNISLWIPPAFGCRPEYDNGLEEIVFGFEPWIIVVNLAMPFSIFYRMHAAA 603

Query: 433 CFADIW 438
              +++
Sbjct: 604 SLFEVY 609


>BC035556-1|AAH35556.1|  538|Homo sapiens dolichol kinase protein.
          Length = 538

 Score = 31.5 bits (68), Expect = 6.3
 Identities = 26/96 (27%), Positives = 52/96 (54%), Gaps = 7/96 (7%)

Query: 240 LMVIIAGMLIIGFVFSSVGEEFLELGYLLNNCTKLTLHTLMLIASL-VTLNQLRKLDINE 298
           L+V++ GM+++G  FS++   F++ G      + +  H +  + SL V L  L +L I  
Sbjct: 227 LLVVVVGMVLMGIFFSTL-FVFMDSG---TWASSIFFHLMTCVLSLGVVLPWLHRL-IRR 281

Query: 299 HPISLLDDVLLFICLPAFFMETFFSLIATISILNIV 334
           +P+  L    LF      ++  ++SL+AT++ L ++
Sbjct: 282 NPLLWLLQ-FLFQTDTRIYLLAYWSLLATLACLVVL 316


>AY727913-1|AAV51404.1| 2472|Homo sapiens RIF1 isoform 4 protein.
          Length = 2472

 Score = 31.5 bits (68), Expect = 6.3
 Identities = 27/106 (25%), Positives = 49/106 (46%), Gaps = 5/106 (4%)

Query: 319 ETFFSLIATISILNIVKTIDFIVMFIQVTIQTPLIMDGLRRCSNTKKLRRSKPGRELLMF 378
           E F +L+    I+ I+  +   + F    I+    +   +R S+  K +    G+   +F
Sbjct: 745 EGFSNLLFVDRIIYIITVMVDCIDFSPYNIKYQPKVKSPQRPSDWSKKKNEPLGKLTSLF 804

Query: 379 LLIANVGMWLLYTFSYKSPESLDERYAFYGKV---LWSILGHVSLP 421
            LI  V ++  +T S+K   S D  +     +   + S+LGH+SLP
Sbjct: 805 KLIVKV-IYSFHTLSFKEAHS-DTLFTIGNSITSIISSVLGHISLP 848


>AY727912-1|AAV51403.1| 2446|Homo sapiens RIF1 protein.
          Length = 2446

 Score = 31.5 bits (68), Expect = 6.3
 Identities = 27/106 (25%), Positives = 49/106 (46%), Gaps = 5/106 (4%)

Query: 319 ETFFSLIATISILNIVKTIDFIVMFIQVTIQTPLIMDGLRRCSNTKKLRRSKPGRELLMF 378
           E F +L+    I+ I+  +   + F    I+    +   +R S+  K +    G+   +F
Sbjct: 745 EGFSNLLFVDRIIYIITVMVDCIDFSPYNIKYQPKVKSPQRPSDWSKKKNEPLGKLTSLF 804

Query: 379 LLIANVGMWLLYTFSYKSPESLDERYAFYGKV---LWSILGHVSLP 421
            LI  V ++  +T S+K   S D  +     +   + S+LGH+SLP
Sbjct: 805 KLIVKV-IYSFHTLSFKEAHS-DTLFTIGNSITSIISSVLGHISLP 848


>AY727911-1|AAV51402.1| 2446|Homo sapiens RIF1 protein.
          Length = 2446

 Score = 31.5 bits (68), Expect = 6.3
 Identities = 27/106 (25%), Positives = 49/106 (46%), Gaps = 5/106 (4%)

Query: 319 ETFFSLIATISILNIVKTIDFIVMFIQVTIQTPLIMDGLRRCSNTKKLRRSKPGRELLMF 378
           E F +L+    I+ I+  +   + F    I+    +   +R S+  K +    G+   +F
Sbjct: 745 EGFSNLLFVDRIIYIITVMVDCIDFSPYNIKYQPKVKSPQRPSDWSKKKNEPLGKLTSLF 804

Query: 379 LLIANVGMWLLYTFSYKSPESLDERYAFYGKV---LWSILGHVSLP 421
            LI  V ++  +T S+K   S D  +     +   + S+LGH+SLP
Sbjct: 805 KLIVKV-IYSFHTLSFKEAHS-DTLFTIGNSITSIISSVLGHISLP 848


>AY727910-1|AAV51401.1| 2446|Homo sapiens RIF1 protein.
          Length = 2446

 Score = 31.5 bits (68), Expect = 6.3
 Identities = 27/106 (25%), Positives = 49/106 (46%), Gaps = 5/106 (4%)

Query: 319 ETFFSLIATISILNIVKTIDFIVMFIQVTIQTPLIMDGLRRCSNTKKLRRSKPGRELLMF 378
           E F +L+    I+ I+  +   + F    I+    +   +R S+  K +    G+   +F
Sbjct: 745 EGFSNLLFVDRIIYIITVMVDCIDFSPYNIKYQPKVKSPQRPSDWSKKKNEPLGKLTSLF 804

Query: 379 LLIANVGMWLLYTFSYKSPESLDERYAFYGKV---LWSILGHVSLP 421
            LI  V ++  +T S+K   S D  +     +   + S+LGH+SLP
Sbjct: 805 KLIVKV-IYSFHTLSFKEAHS-DTLFTIGNSITSIISSVLGHISLP 848


>AY585745-1|AAT40745.1| 2472|Homo sapiens Rap1 interacting factor 1
           protein.
          Length = 2472

 Score = 31.5 bits (68), Expect = 6.3
 Identities = 27/106 (25%), Positives = 49/106 (46%), Gaps = 5/106 (4%)

Query: 319 ETFFSLIATISILNIVKTIDFIVMFIQVTIQTPLIMDGLRRCSNTKKLRRSKPGRELLMF 378
           E F +L+    I+ I+  +   + F    I+    +   +R S+  K +    G+   +F
Sbjct: 745 EGFSNLLFVDRIIYIITVMVDCIDFSPYNIKYQPKVKSPQRPSDWSKKKNEPLGKLTSLF 804

Query: 379 LLIANVGMWLLYTFSYKSPESLDERYAFYGKV---LWSILGHVSLP 421
            LI  V ++  +T S+K   S D  +     +   + S+LGH+SLP
Sbjct: 805 KLIVKV-IYSFHTLSFKEAHS-DTLFTIGNSITGIISSVLGHISLP 848


>AY584066-1|AAS94233.1| 2472|Homo sapiens telomeric protein RIF1
           protein.
          Length = 2472

 Score = 31.5 bits (68), Expect = 6.3
 Identities = 27/106 (25%), Positives = 49/106 (46%), Gaps = 5/106 (4%)

Query: 319 ETFFSLIATISILNIVKTIDFIVMFIQVTIQTPLIMDGLRRCSNTKKLRRSKPGRELLMF 378
           E F +L+    I+ I+  +   + F    I+    +   +R S+  K +    G+   +F
Sbjct: 745 EGFSNLLFVDRIIYIITVMVDCIDFSPYNIKYQPKVKSPQRPSDWSKKKNEPLGKLTSLF 804

Query: 379 LLIANVGMWLLYTFSYKSPESLDERYAFYGKV---LWSILGHVSLP 421
            LI  V ++  +T S+K   S D  +     +   + S+LGH+SLP
Sbjct: 805 KLIVKV-IYSFHTLSFKEAHS-DTLFTIGNSITGIISSVLGHISLP 848


>AY358759-1|AAQ89119.1|  538|Homo sapiens TREC2422 protein.
          Length = 538

 Score = 31.5 bits (68), Expect = 6.3
 Identities = 26/96 (27%), Positives = 52/96 (54%), Gaps = 7/96 (7%)

Query: 240 LMVIIAGMLIIGFVFSSVGEEFLELGYLLNNCTKLTLHTLMLIASL-VTLNQLRKLDINE 298
           L+V++ GM+++G  FS++   F++ G      + +  H +  + SL V L  L +L I  
Sbjct: 227 LLVVVVGMVLMGIFFSTL-FVFMDSG---TWASSIFFHLMTCVLSLGVVLPWLHRL-IRR 281

Query: 299 HPISLLDDVLLFICLPAFFMETFFSLIATISILNIV 334
           +P+  L    LF      ++  ++SL+AT++ L ++
Sbjct: 282 NPLLWLLQ-FLFQTDTRIYLLAYWSLLATLACLVVL 316


>AL672142-7|CAI10844.1|  538|Homo sapiens transmembrane protein 15
           protein.
          Length = 538

 Score = 31.5 bits (68), Expect = 6.3
 Identities = 26/96 (27%), Positives = 52/96 (54%), Gaps = 7/96 (7%)

Query: 240 LMVIIAGMLIIGFVFSSVGEEFLELGYLLNNCTKLTLHTLMLIASL-VTLNQLRKLDINE 298
           L+V++ GM+++G  FS++   F++ G      + +  H +  + SL V L  L +L I  
Sbjct: 227 LLVVVVGMVLMGIFFSTL-FVFMDSG---TWASSIFFHLMTCVLSLGVVLPWLHRL-IRR 281

Query: 299 HPISLLDDVLLFICLPAFFMETFFSLIATISILNIV 334
           +P+  L    LF      ++  ++SL+AT++ L ++
Sbjct: 282 NPLLWLLQ-FLFQTDTRIYLLAYWSLLATLACLVVL 316


>AK024033-1|BAB14792.1|  719|Homo sapiens protein ( Homo sapiens
           cDNA FLJ13971 fis, clone Y79AA1001541. ).
          Length = 719

 Score = 31.5 bits (68), Expect = 6.3
 Identities = 27/106 (25%), Positives = 49/106 (46%), Gaps = 5/106 (4%)

Query: 319 ETFFSLIATISILNIVKTIDFIVMFIQVTIQTPLIMDGLRRCSNTKKLRRSKPGRELLMF 378
           E F +L+    I+ I+  +   + F    I+    +   +R S+  K +    G+   +F
Sbjct: 98  EGFSNLLFVDRIIYIITVMVDCIDFSPYNIKYQPKVKSPQRPSDWSKKKNEPLGKLTSLF 157

Query: 379 LLIANVGMWLLYTFSYKSPESLDERYAFYGKV---LWSILGHVSLP 421
            LI  V ++  +T S+K   S D  +     +   + S+LGH+SLP
Sbjct: 158 KLIVKV-IYSFHTLSFKEAHS-DTLFTIGNSITSIISSVLGHISLP 201


>AK022932-1|BAB14313.1|  838|Homo sapiens protein ( Homo sapiens
           cDNA FLJ12870 fis, clone NT2RP2003727. ).
          Length = 838

 Score = 31.5 bits (68), Expect = 6.3
 Identities = 27/106 (25%), Positives = 49/106 (46%), Gaps = 5/106 (4%)

Query: 319 ETFFSLIATISILNIVKTIDFIVMFIQVTIQTPLIMDGLRRCSNTKKLRRSKPGRELLMF 378
           E F +L+    I+ I+  +   + F    I+    +   +R S+  K +    G+   +F
Sbjct: 569 EGFSNLLFVDRIIYIITVMVDCIDFSPYNIKYQPKVKSPQRPSDWSKKKNEPLGKLTSLF 628

Query: 379 LLIANVGMWLLYTFSYKSPESLDERYAFYGKV---LWSILGHVSLP 421
            LI  V ++  +T S+K   S D  +     +   + S+LGH+SLP
Sbjct: 629 KLIVKV-IYSFHTLSFKEAHS-DTLFTIGNSITGIISSVLGHISLP 672


>AK001461-1|BAA91705.1|  852|Homo sapiens protein ( Homo sapiens
           cDNA FLJ10599 fis, clone NT2RP2004959. ).
          Length = 852

 Score = 31.5 bits (68), Expect = 6.3
 Identities = 27/106 (25%), Positives = 49/106 (46%), Gaps = 5/106 (4%)

Query: 319 ETFFSLIATISILNIVKTIDFIVMFIQVTIQTPLIMDGLRRCSNTKKLRRSKPGRELLMF 378
           E F +L+    I+ I+  +   + F    I+    +   +R S+  K +    G+   +F
Sbjct: 98  EGFSNLLFVDRIIYIITVMVDCIDFSPYNIKYQPKVKSPQRPSDWSKKKNEPLGKLTSLF 157

Query: 379 LLIANVGMWLLYTFSYKSPESLDERYAFYGKV---LWSILGHVSLP 421
            LI  V ++  +T S+K   S D  +     +   + S+LGH+SLP
Sbjct: 158 KLIVKV-IYSFHTLSFKEAHS-DTLFTIGNSITGIISSVLGHISLP 201


>AB029017-1|BAA83046.2|  544|Homo sapiens KIAA1094 protein protein.
          Length = 544

 Score = 31.5 bits (68), Expect = 6.3
 Identities = 26/96 (27%), Positives = 52/96 (54%), Gaps = 7/96 (7%)

Query: 240 LMVIIAGMLIIGFVFSSVGEEFLELGYLLNNCTKLTLHTLMLIASL-VTLNQLRKLDINE 298
           L+V++ GM+++G  FS++   F++ G      + +  H +  + SL V L  L +L I  
Sbjct: 233 LLVVVVGMVLMGIFFSTL-FVFMDSG---TWASSIFFHLMTCVLSLGVVLPWLHRL-IRR 287

Query: 299 HPISLLDDVLLFICLPAFFMETFFSLIATISILNIV 334
           +P+  L    LF      ++  ++SL+AT++ L ++
Sbjct: 288 NPLLWLLQ-FLFQTDTRIYLLAYWSLLATLACLVVL 322


  Database: human
    Posted date:  Oct 5, 2007 11:13 AM
  Number of letters in database: 73,234,838
  Number of sequences in database:  224,733
  
Lambda     K      H
   0.328    0.143    0.443 

Gapped
Lambda     K      H
   0.279   0.0580    0.190 


Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 66,400,147
Number of Sequences: 224733
Number of extensions: 2710589
Number of successful extensions: 6158
Number of sequences better than 10.0: 15
Number of HSP's better than 10.0 without gapping: 2
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 6151
Number of HSP's gapped (non-prelim): 20
length of query: 448
length of database: 73,234,838
effective HSP length: 92
effective length of query: 356
effective length of database: 52,559,402
effective search space: 18711147112
effective search space used: 18711147112
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 40 (21.8 bits)
S2: 67 (31.1 bits)

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