Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001183-TA|BGIBMGA001183-PA|IPR003599|Immunoglobulin
subtype, IPR003598|Immunoglobulin subtype 2, IPR001245|Tyrosine
protein kinase, IPR002290|Serine/threonine protein kinase,
IPR000719|Protein kinase, IPR008266|Tyrosine protein kinase, active
site, IPR013838|Beta tubulin, autoregulation binding site,
IPR001824|Receptor tyrosine kinase, class III,
IPR007110|Immunoglobulin-like, IPR011009|Protein kinase-like,
IPR013151|Immunoglobulin, IPR013098|Immunoglobulin I-set
(1158 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_UPI00015B5C00 Cluster: PREDICTED: similar to VEGFR-A sp... 544 e-153
UniRef50_Q8T4M0 Cluster: VEGFR-A splice form A; n=4; Diptera|Rep... 487 e-136
UniRef50_Q0IFX6 Cluster: Pdgf/vegf receptor; n=1; Aedes aegypti|... 473 e-131
UniRef50_UPI0000DB7A0A Cluster: PREDICTED: similar to FMS-like t... 371 e-101
UniRef50_Q8AXB3 Cluster: Vascular endothelial growth factor rece... 344 7e-93
UniRef50_P17948 Cluster: Vascular endothelial growth factor rece... 343 1e-92
UniRef50_P35968 Cluster: Vascular endothelial growth factor rece... 336 2e-90
UniRef50_Q4JDD5 Cluster: Tyrosine-protein kinase receptor; n=5; ... 331 7e-89
UniRef50_Q4SJQ3 Cluster: Tyrosine-protein kinase receptor; n=1; ... 325 5e-87
UniRef50_Q4RP85 Cluster: Tyrosine-protein kinase receptor; n=3; ... 303 2e-80
UniRef50_Q4H2M8 Cluster: Tyrosine-protein kinase receptor; n=1; ... 301 7e-80
UniRef50_P16234 Cluster: Alpha-type platelet-derived growth fact... 289 3e-76
UniRef50_Q9VLQ8 Cluster: CG8222-PA, isoform A; n=8; Sophophora|R... 278 7e-73
UniRef50_P79749 Cluster: Beta-type platelet-derived growth facto... 277 1e-72
UniRef50_P10721 Cluster: Mast/stem cell growth factor receptor p... 277 2e-72
UniRef50_Q8JFR5 Cluster: Mast/stem cell growth factor receptor p... 277 2e-72
UniRef50_UPI0001555344 Cluster: PREDICTED: similar to Kinase ins... 275 5e-72
UniRef50_Q640T5 Cluster: Tyrosine-protein kinase receptor; n=2; ... 275 5e-72
UniRef50_Q9U8U8 Cluster: VEGFR-like; n=1; Branchiostoma belcheri... 272 5e-71
UniRef50_P09619 Cluster: Beta-type platelet-derived growth facto... 265 4e-69
UniRef50_Q1HTP1 Cluster: Tyrosine-protein kinase receptor; n=1; ... 264 1e-68
UniRef50_P36888 Cluster: FL cytokine receptor precursor; n=33; A... 263 2e-68
UniRef50_P07333 Cluster: Macrophage colony-stimulating factor 1 ... 262 3e-68
UniRef50_Q8UVR8 Cluster: Macrophage colony-stimulating factor 1 ... 262 3e-68
UniRef50_Q1HTP2 Cluster: Tyrosine-protein kinase receptor; n=4; ... 258 6e-67
UniRef50_Q9I8N6 Cluster: Macrophage colony-stimulating factor 1 ... 258 6e-67
UniRef50_UPI0000D8BE91 Cluster: UPI0000D8BE91 related cluster; n... 254 8e-66
UniRef50_Q4RKW0 Cluster: Tyrosine-protein kinase receptor; n=1; ... 236 3e-60
UniRef50_Q4S569 Cluster: Chromosome 6 SCAF14737, whole genome sh... 221 1e-55
UniRef50_UPI00015B54DC Cluster: PREDICTED: similar to vascular e... 219 4e-55
UniRef50_Q16RK6 Cluster: Receptor protein tyrosine kinase; n=1; ... 214 1e-53
UniRef50_Q9U8U9 Cluster: PDGFR-like; n=1; Eptatretus burgeri|Rep... 212 5e-53
UniRef50_P11362 Cluster: Basic fibroblast growth factor receptor... 198 7e-49
UniRef50_P22182 Cluster: Fibroblast growth factor receptor 1 pre... 197 1e-48
UniRef50_Q3TJ05 Cluster: 14 days pregnant adult female placenta ... 196 2e-48
UniRef50_UPI0000D55449 Cluster: PREDICTED: similar to CG7223-PA,... 194 1e-47
UniRef50_P35916 Cluster: Vascular endothelial growth factor rece... 193 2e-47
UniRef50_Q8IXC7 Cluster: Isoform of FGFR2; n=23; Euteleostomi|Re... 190 2e-46
UniRef50_Q8JG38 Cluster: Fibroblast growth factor receptor 2 pre... 190 2e-46
UniRef50_Q1JUB8 Cluster: Fibroblast growth factor receptor; n=2;... 190 3e-46
UniRef50_A7SI92 Cluster: Predicted protein; n=2; Nematostella ve... 190 3e-46
UniRef50_A3EXK4 Cluster: Fibroblast growth factor receptor a; n=... 190 3e-46
UniRef50_Q59F30 Cluster: Fibroblast growth factor receptor 4 var... 189 4e-46
UniRef50_Q5GIT4 Cluster: Vascular endothelial growth factor rece... 189 4e-46
UniRef50_A7RZ71 Cluster: Predicted protein; n=1; Nematostella ve... 187 1e-45
UniRef50_Q7PYY7 Cluster: ENSANGP00000019144; n=1; Anopheles gamb... 187 2e-45
UniRef50_Q4S1S8 Cluster: Chromosome undetermined SCAF14764, whol... 186 2e-45
UniRef50_A3EXK5 Cluster: Fibroblast growth factor receptor b; n=... 186 2e-45
UniRef50_Q2VJ45 Cluster: HOOK3-RET fusion protein; n=3; Eutheria... 186 2e-45
UniRef50_P07949 Cluster: Proto-oncogene tyrosine-protein kinase ... 186 2e-45
UniRef50_Q26614 Cluster: Fibroblast growth factor receptor precu... 185 5e-45
UniRef50_Q95YM9 Cluster: Fibroblast growth factor receptor precu... 185 5e-45
UniRef50_Q03142 Cluster: Fibroblast growth factor receptor 4 pre... 185 5e-45
UniRef50_Q7Q0U2 Cluster: ENSANGP00000012311; n=1; Anopheles gamb... 184 1e-44
UniRef50_Q7Z1L9 Cluster: Neurite outgrowth regulated kinase; n=1... 184 2e-44
UniRef50_Q9VBW3 Cluster: Tyrosine kinase receptor Cad96Ca precur... 182 5e-44
UniRef50_A7SL46 Cluster: Predicted protein; n=2; Eumetazoa|Rep: ... 182 7e-44
UniRef50_Q17J18 Cluster: Tyrosine-protein kinase; n=4; Endoptery... 180 2e-43
UniRef50_UPI0000DB7F8D Cluster: PREDICTED: similar to Cad96Ca CG... 179 5e-43
UniRef50_Q09147 Cluster: Fibroblast growth factor receptor homol... 178 8e-43
UniRef50_P08581 Cluster: Hepatocyte growth factor receptor precu... 177 1e-42
UniRef50_Q4SR43 Cluster: Chromosome 11 SCAF14528, whole genome s... 176 3e-42
UniRef50_UPI0000D57178 Cluster: PREDICTED: similar to CG14396-PA... 175 6e-42
UniRef50_P79950 Cluster: Tyrosine kinase receptor; n=3; Xenopus|... 175 6e-42
UniRef50_Q674V1 Cluster: Vascular endothelial growth factor rece... 174 1e-41
UniRef50_Q17IF1 Cluster: Receptor protein tyrosine kinase; n=1; ... 174 1e-41
UniRef50_A7RGW8 Cluster: Predicted protein; n=1; Nematostella ve... 174 1e-41
UniRef50_Q64GK4 Cluster: C-Met receptor tyrosine kinase; n=9; Cl... 174 1e-41
UniRef50_Q07407 Cluster: Fibroblast growth factor receptor homol... 174 1e-41
UniRef50_Q86PM4 Cluster: Fibroblast growth factor receptor precu... 173 2e-41
UniRef50_Q10656-2 Cluster: Isoform b of Q10656 ; n=4; Caenorhabd... 173 3e-41
UniRef50_Q4RXB0 Cluster: Chromosome 11 SCAF14979, whole genome s... 173 3e-41
UniRef50_Q4RKW3 Cluster: Tyrosine-protein kinase receptor; n=1; ... 173 3e-41
UniRef50_Q10656 Cluster: Myoblast growth factor receptor egl-15 ... 173 3e-41
UniRef50_UPI00015B51DA Cluster: PREDICTED: similar to ENSANGP000... 172 5e-41
UniRef50_A7RVU0 Cluster: Predicted protein; n=1; Nematostella ve... 172 5e-41
UniRef50_UPI00015B4DC3 Cluster: PREDICTED: similar to receptor t... 171 7e-41
UniRef50_Q9YGM5 Cluster: Plasminogen related growth factor recep... 171 7e-41
UniRef50_A7RHT9 Cluster: Predicted protein; n=1; Nematostella ve... 171 1e-40
UniRef50_Q6DTW4 Cluster: Tyrosine kinase receptor ron; n=6; Eume... 169 3e-40
UniRef50_Q5DM52 Cluster: Receptor tyrosine kinase Torso-like pro... 169 5e-40
UniRef50_UPI0000D57494 Cluster: PREDICTED: similar to insulin re... 168 9e-40
UniRef50_Q8INU0 Cluster: CG14396-PD, isoform D; n=10; Sophophora... 168 9e-40
UniRef50_UPI00015B4CAE Cluster: PREDICTED: similar to ENSANGP000... 167 2e-39
UniRef50_P18475 Cluster: Tyrosine-protein kinase receptor torso ... 167 2e-39
UniRef50_P23049 Cluster: Tyrosine-protein kinase transforming pr... 167 2e-39
UniRef50_P30530 Cluster: Tyrosine-protein kinase receptor UFO pr... 166 3e-39
UniRef50_Q7YT64 Cluster: Tyrosine-protein kinase receptor; n=1; ... 166 4e-39
UniRef50_Q02763 Cluster: Angiopoietin-1 receptor precursor; n=41... 166 4e-39
UniRef50_Q93105 Cluster: Insulin-like receptor precursor (EC 2.7... 165 6e-39
UniRef50_UPI00004D7E5F Cluster: Proto-oncogene tyrosine-protein ... 165 8e-39
UniRef50_Q7PWP1 Cluster: ENSANGP00000013218; n=2; Culicidae|Rep:... 165 8e-39
UniRef50_Q04912 Cluster: Macrophage-stimulating protein receptor... 163 2e-38
UniRef50_UPI0000D55DFF Cluster: PREDICTED: similar to Insulin-li... 163 3e-38
UniRef50_O76809 Cluster: Receptor tyrosine kinase HTK30; n=1; Hy... 162 4e-38
UniRef50_Q25199 Cluster: Tyrosine kinase receptor; n=7; Hydra|Re... 162 6e-38
UniRef50_Q25177 Cluster: Receptor protein-tyrosine kinase; n=2; ... 162 6e-38
UniRef50_Q9U5A8 Cluster: Insulin receptor-like protein precursor... 161 1e-37
UniRef50_Q8MY85 Cluster: Fibroblast growth factor receptor 2 pre... 161 1e-37
UniRef50_Q70W11 Cluster: Receptor tyrosine kinase X; n=1; Ciona ... 160 2e-37
UniRef50_Q7Q0F6 Cluster: Tyrosine-protein kinase receptor; n=2; ... 160 2e-37
UniRef50_Q06418 Cluster: Tyrosine-protein kinase receptor TYRO3 ... 160 2e-37
UniRef50_Q5BXN9 Cluster: SJCHGC05493 protein; n=1; Schistosoma j... 159 3e-37
UniRef50_Q9Y1Y7 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 159 4e-37
UniRef50_P09208 Cluster: Insulin-like receptor precursor (EC 2.7... 159 4e-37
UniRef50_A7RGV3 Cluster: Predicted protein; n=1; Nematostella ve... 159 5e-37
UniRef50_Q9YI66 Cluster: Developmental receptor tyrosine kinase;... 158 7e-37
UniRef50_Q5K4G5 Cluster: Receptor tyrosine kinase; n=1; Suberite... 158 9e-37
UniRef50_UPI00015B5959 Cluster: PREDICTED: similar to insulin re... 157 1e-36
UniRef50_UPI0000E49FB6 Cluster: PREDICTED: similar to RE05926p, ... 157 1e-36
UniRef50_Q4RJ67 Cluster: Chromosome 1 SCAF15039, whole genome sh... 157 1e-36
UniRef50_A7RNB1 Cluster: Predicted protein; n=1; Nematostella ve... 157 1e-36
UniRef50_Q12866 Cluster: Proto-oncogene tyrosine-protein kinase ... 157 1e-36
UniRef50_O97191 Cluster: Tyrosine-protein kinase receptor; n=1; ... 157 2e-36
UniRef50_A7S934 Cluster: Predicted protein; n=4; Nematostella ve... 157 2e-36
UniRef50_Q25197 Cluster: Putative insulin-like peptide receptor ... 157 2e-36
UniRef50_UPI00015B5971 Cluster: PREDICTED: similar to leukocyte ... 156 3e-36
UniRef50_A7SAX2 Cluster: Predicted protein; n=3; Nematostella ve... 156 3e-36
UniRef50_O15146 Cluster: Muscle, skeletal receptor tyrosine prot... 156 3e-36
UniRef50_O02466 Cluster: Insulin-like peptide receptor precursor... 156 3e-36
UniRef50_UPI0000D55B96 Cluster: PREDICTED: similar to Tyrosine-p... 156 4e-36
UniRef50_Q4H3N2 Cluster: Epidermal growth factor receptor; n=1; ... 156 4e-36
UniRef50_UPI000065F6B2 Cluster: Receptor tyrosine-protein kinase... 155 5e-36
UniRef50_Q4RWP2 Cluster: Tyrosine-protein kinase receptor; n=1; ... 155 5e-36
UniRef50_Q5TRF2 Cluster: ENSANGP00000025511; n=1; Anopheles gamb... 155 5e-36
UniRef50_UPI0000DB6DD4 Cluster: PREDICTED: similar to Insulin-li... 155 7e-36
UniRef50_Q8IQ00 Cluster: CG3277-PB, isoform B; n=3; Sophophora|R... 155 7e-36
UniRef50_Q9Y1Z0 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 154 1e-35
UniRef50_A7SE14 Cluster: Predicted protein; n=4; Nematostella ve... 154 1e-35
UniRef50_Q15303 Cluster: Receptor tyrosine-protein kinase erbB-4... 154 1e-35
UniRef50_Q9Y1X9 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 153 2e-35
UniRef50_P00533 Cluster: Epidermal growth factor receptor precur... 153 2e-35
UniRef50_P35590 Cluster: Tyrosine-protein kinase receptor Tie-1 ... 153 3e-35
UniRef50_Q7YZH7 Cluster: MBRTK2; n=1; Monosiga brevicollis|Rep: ... 153 4e-35
UniRef50_Q6SAJ2 Cluster: Epidermal growth factor receptor; n=11;... 153 4e-35
UniRef50_Q6SAA3 Cluster: Epidermal growth factor receptor; n=39;... 153 4e-35
UniRef50_Q4H3N3 Cluster: Epidermal growth factor receptor; n=1; ... 153 4e-35
UniRef50_P04412 Cluster: Epidermal growth factor receptor precur... 153 4e-35
UniRef50_Q4RZA4 Cluster: Chromosome 1 SCAF14944, whole genome sh... 152 5e-35
UniRef50_Q9XYS4 Cluster: Tyrosine kinase receptor HTK32; n=1; Hy... 152 5e-35
UniRef50_A3EXK6 Cluster: Fibroblast growth factor receptor c; n=... 152 5e-35
UniRef50_Q9PVZ4 Cluster: Insulin receptor precursor (EC 2.7.10.1... 152 5e-35
UniRef50_P08922 Cluster: Proto-oncogene tyrosine-protein kinase ... 152 6e-35
UniRef50_P00534 Cluster: Tyrosine-protein kinase transforming pr... 152 6e-35
UniRef50_P08069 Cluster: Insulin-like growth factor 1 receptor p... 151 1e-34
UniRef50_Q4H3B8 Cluster: Tyrosine-protein kinase receptor; n=1; ... 151 1e-34
UniRef50_O76385 Cluster: Putative uncharacterized protein; n=3; ... 151 1e-34
UniRef50_Q8AXY6 Cluster: Muscle, skeletal receptor tyrosine prot... 151 1e-34
UniRef50_Q86MD7 Cluster: EGF receptor; n=1; Echinococcus multilo... 150 2e-34
UniRef50_Q17LF1 Cluster: Muscle-specific tyrosine kinase recepto... 150 2e-34
UniRef50_P00528 Cluster: Tyrosine-protein kinase Src64B; n=6; En... 150 2e-34
UniRef50_O73798 Cluster: Insulin-like growth factor 1 receptor p... 150 2e-34
UniRef50_Q8MY86 Cluster: Fibroblast growth factor receptor 1 pre... 150 2e-34
UniRef50_Q21038 Cluster: Putative uncharacterized protein ver-3;... 150 2e-34
UniRef50_Q25410 Cluster: Putative molluscan insulin-related pept... 150 2e-34
UniRef50_P06213 Cluster: Insulin receptor precursor (EC 2.7.10.1... 150 2e-34
UniRef50_P14616 Cluster: Insulin receptor-related protein precur... 150 2e-34
UniRef50_UPI00015B4A8D Cluster: PREDICTED: similar to receptor t... 149 3e-34
UniRef50_P34925 Cluster: Tyrosine-protein kinase RYK precursor; ... 149 3e-34
UniRef50_UPI0000DB6D22 Cluster: PREDICTED: similar to Alk CG8250... 149 4e-34
UniRef50_UPI0000D57520 Cluster: PREDICTED: similar to CG8250-PA;... 149 4e-34
UniRef50_Q9Y1Y3 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 149 4e-34
UniRef50_P53356 Cluster: Tyrosine-protein kinase HTK16; n=1; Hyd... 149 4e-34
UniRef50_Q179Z3 Cluster: Tyrosine-protein kinase; n=1; Aedes aeg... 149 6e-34
UniRef50_Q9V6K3 Cluster: Tyrosine-protein kinase transmembrane r... 149 6e-34
UniRef50_Q9Y1Y5 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 148 1e-33
UniRef50_Q4S572 Cluster: Tyrosine-protein kinase receptor; n=2; ... 147 1e-33
UniRef50_Q4RH14 Cluster: Chromosome undetermined SCAF15074, whol... 147 1e-33
UniRef50_Q17833 Cluster: Putative uncharacterized protein old-1;... 147 1e-33
UniRef50_P34892 Cluster: Receptor-like tyrosine-protein kinase k... 147 2e-33
UniRef50_UPI0000D569CE Cluster: PREDICTED: similar to CG10023-PA... 146 3e-33
UniRef50_Q4TBR4 Cluster: Chromosome undetermined SCAF7099, whole... 146 3e-33
UniRef50_Q60WJ5 Cluster: Putative uncharacterized protein CBG191... 146 3e-33
UniRef50_Q170Z1 Cluster: Tyrosine-protein kinase receptor; n=1; ... 146 3e-33
UniRef50_UPI00015B6133 Cluster: PREDICTED: similar to protein ty... 146 4e-33
UniRef50_Q9XVQ7 Cluster: Putative uncharacterized protein; n=2; ... 146 4e-33
UniRef50_Q008W6 Cluster: Gamma-carboxyglutamic acid protein 1; n... 146 4e-33
UniRef50_P04626 Cluster: Receptor tyrosine-protein kinase erbB-2... 146 4e-33
UniRef50_Q7KJ08 Cluster: Receptor protein tyrosine kinase ALK sp... 145 5e-33
UniRef50_P00522 Cluster: Tyrosine-protein kinase Abl; n=5; Eumet... 145 5e-33
UniRef50_UPI00015B4B0F Cluster: PREDICTED: similar to proto-onco... 145 7e-33
UniRef50_UPI0000519AF4 Cluster: PREDICTED: similar to Abl tyrosi... 145 7e-33
UniRef50_UPI0000E471D0 Cluster: PREDICTED: similar to p80 protei... 144 1e-32
UniRef50_UPI00015B55E4 Cluster: PREDICTED: similar to receptor-l... 143 2e-32
UniRef50_UPI0000D57699 Cluster: PREDICTED: similar to CG18247-PA... 143 2e-32
UniRef50_UPI000065FEDC Cluster: Activated CDC42 kinase 1 (EC 2.7... 143 2e-32
UniRef50_Q9Y1Y2 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 143 2e-32
UniRef50_Q70W09 Cluster: Receptor tyrosine kinase VIII; n=1; Cio... 143 2e-32
UniRef50_O77440 Cluster: Protein-tyrosine kinase HTK98; n=1; Hyd... 143 2e-32
UniRef50_Q19238 Cluster: Putative tyrosine-protein kinase F09A5.... 143 2e-32
UniRef50_Q9BKL8 Cluster: Tyrosine-protein kinase receptor; n=2; ... 143 3e-32
UniRef50_Q2LC18 Cluster: Tyrosine-protein kinase receptor; n=2; ... 143 3e-32
UniRef50_A7SZN9 Cluster: Predicted protein; n=3; Nematostella ve... 143 3e-32
UniRef50_P00529 Cluster: Tyrosine-protein kinase transforming pr... 143 3e-32
UniRef50_Q91987 Cluster: BDNF/NT-3 growth factors receptor precu... 143 3e-32
UniRef50_Q8WRF4 Cluster: Receptor tyrosine kinase; n=1; Monosiga... 142 4e-32
UniRef50_Q86LZ8 Cluster: Insulin receptor protein kinase; n=2; S... 142 4e-32
UniRef50_Q22489 Cluster: Putative uncharacterized protein; n=4; ... 142 5e-32
UniRef50_Q21041 Cluster: Putative uncharacterized protein ver-4;... 142 5e-32
UniRef50_O17408 Cluster: Putative uncharacterized protein; n=1; ... 142 5e-32
UniRef50_Q9Y1Y9 Cluster: Protein tyrosine kinase; n=3; Metazoa|R... 142 7e-32
UniRef50_Q9H3Y6 Cluster: Tyrosine-protein kinase Srms; n=17; Amn... 142 7e-32
UniRef50_P08631 Cluster: Tyrosine-protein kinase HCK; n=32; Eute... 142 7e-32
UniRef50_Q4SK07 Cluster: Tyrosine-protein kinase receptor; n=2; ... 141 9e-32
UniRef50_Q7YXV8 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 141 9e-32
UniRef50_P42685 Cluster: Tyrosine-protein kinase FRK; n=27; Fung... 141 9e-32
UniRef50_P42684 Cluster: Tyrosine-protein kinase ABL2; n=38; Eut... 141 9e-32
UniRef50_UPI0000F2052A Cluster: PREDICTED: similar to anaplastic... 141 1e-31
UniRef50_UPI0000E48358 Cluster: PREDICTED: hypothetical protein;... 141 1e-31
UniRef50_Q6PUA9 Cluster: Receptor tyrosine kinase c-kit; n=1; Am... 141 1e-31
UniRef50_Q9U531 Cluster: Focal adhesion kinase homolog DFak56; n... 141 1e-31
UniRef50_O17391 Cluster: Protein kinase protein 9, isoform b; n=... 141 1e-31
UniRef50_Q910A2 Cluster: Spleen protein tyrosine kinase; n=2; Da... 140 2e-31
UniRef50_Q4SQ93 Cluster: Tyrosine-protein kinase receptor; n=2; ... 140 2e-31
UniRef50_Q70DV1 Cluster: Src tyrosine kinase; n=1; Schistosoma m... 140 2e-31
UniRef50_A6NNJ8 Cluster: Uncharacterized protein LTK; n=12; Euar... 140 2e-31
UniRef50_P04629 Cluster: High affinity nerve growth factor recep... 140 2e-31
UniRef50_P41240 Cluster: Tyrosine-protein kinase CSK; n=21; Deut... 140 2e-31
UniRef50_P13368 Cluster: Protein sevenless; n=20; Eumetazoa|Rep:... 140 2e-31
UniRef50_Q9N4T2 Cluster: Putative uncharacterized protein Y50D4B... 140 3e-31
UniRef50_Q26566 Cluster: Epidermal growth factor receptor precur... 140 3e-31
UniRef50_O77132 Cluster: Non-receptor protein-tyrosine kinase CS... 140 3e-31
UniRef50_Q16620 Cluster: BDNF/NT-3 growth factors receptor precu... 140 3e-31
UniRef50_Q16XX9 Cluster: Tyrosine-protein kinase shark; n=2; Cul... 139 4e-31
UniRef50_P03949 Cluster: Tyrosine-protein kinase abl-1; n=5; Cae... 139 4e-31
UniRef50_Q4SMB8 Cluster: Chromosome 3 SCAF14553, whole genome sh... 139 5e-31
UniRef50_Q24145 Cluster: Tyrosine-protein kinase shark; n=2; Sop... 139 5e-31
UniRef50_P00521 Cluster: Tyrosine-protein kinase transforming pr... 139 5e-31
UniRef50_UPI0000E48523 Cluster: PREDICTED: similar to protein-ty... 138 6e-31
UniRef50_P00519 Cluster: Proto-oncogene tyrosine-protein kinase ... 138 6e-31
UniRef50_Q24488 Cluster: Tyrosine-protein kinase transmembrane r... 138 8e-31
UniRef50_P08923 Cluster: Leukocyte tyrosine kinase receptor prec... 138 8e-31
UniRef50_P34891 Cluster: Receptor-like tyrosine-protein kinase k... 138 8e-31
UniRef50_Q07912 Cluster: Activated CDC42 kinase 1; n=24; Euteleo... 138 8e-31
UniRef50_Q8T0W6 Cluster: Putative insulin receptor precursor; n=... 138 1e-30
UniRef50_Q6R1Y3 Cluster: Src family kinase; n=6; Fungi/Metazoa g... 138 1e-30
UniRef50_Q5I4E2 Cluster: Bm-DAF-2 precursor; n=1; Brugia malayi|... 138 1e-30
UniRef50_P42680 Cluster: Tyrosine-protein kinase Tec; n=86; Coel... 138 1e-30
UniRef50_Q9TX48 Cluster: 220 kDa ABL-related protein tyrosine ki... 137 1e-30
UniRef50_Q7Q5T3 Cluster: Tyrosine-protein kinase receptor; n=3; ... 137 1e-30
UniRef50_Q70W05 Cluster: Src protein; n=1; Ciona intestinalis|Re... 137 1e-30
UniRef50_Q6NP28 Cluster: LP09923p; n=6; Endopterygota|Rep: LP099... 137 1e-30
UniRef50_Q17MF5 Cluster: Tyrosine-protein kinase; n=2; Culicidae... 137 2e-30
UniRef50_P42679 Cluster: Megakaryocyte-associated tyrosine-prote... 137 2e-30
UniRef50_O02742 Cluster: Activated CDC42 kinase 2; n=13; Euteleo... 137 2e-30
UniRef50_Q4S351 Cluster: Chromosome 4 SCAF14752, whole genome sh... 136 2e-30
UniRef50_Q5TUS8 Cluster: Tyrosine-protein kinase receptor; n=1; ... 136 2e-30
UniRef50_Q17C76 Cluster: Focal adhesion kinase; n=2; Culicidae|R... 136 2e-30
UniRef50_O76148 Cluster: Tyrosine-protein kinase receptor; n=1; ... 136 2e-30
UniRef50_Q08881 Cluster: Tyrosine-protein kinase ITK/TSK; n=18; ... 136 2e-30
UniRef50_UPI0000DB6C99 Cluster: PREDICTED: similar to proto-onco... 136 3e-30
UniRef50_Q10925-2 Cluster: Isoform b of Q10925 ; n=2; Caenorhabd... 136 3e-30
UniRef50_Q9Y1Y8 Cluster: Protein tyrosine kinase; n=2; Metazoa|R... 136 3e-30
UniRef50_Q4H3M7 Cluster: Ephrin receptor; n=3; Ciona|Rep: Ephrin... 136 3e-30
UniRef50_Q10925 Cluster: Probable tyrosine-protein kinase kin-25... 136 3e-30
UniRef50_Q4RL31 Cluster: Chromosome undetermined SCAF15024, whol... 136 4e-30
UniRef50_Q9NH62 Cluster: Tyrosine kinase 5; n=2; Schistosoma man... 136 4e-30
UniRef50_A7RNB2 Cluster: Predicted protein; n=1; Nematostella ve... 136 4e-30
UniRef50_P10447 Cluster: Tyrosine-protein kinase transforming pr... 136 4e-30
UniRef50_UPI0000DB72A0 Cluster: PREDICTED: similar to R151.4a; n... 135 6e-30
UniRef50_Q9BLY1 Cluster: Receptor tyrosine kinase; n=5; Caenorha... 135 6e-30
UniRef50_Q05397 Cluster: Focal adhesion kinase 1; n=111; Euteleo... 135 6e-30
UniRef50_Q06187 Cluster: Tyrosine-protein kinase BTK; n=54; Gnat... 135 6e-30
UniRef50_Q16VL6 Cluster: Tyrosine-protein kinase; n=1; Aedes aeg... 135 8e-30
UniRef50_Q7YZX2 Cluster: Bruton's tyrosine kinase-like protein; ... 134 1e-29
UniRef50_A6P4V4 Cluster: Tyrosine-protein kinase receptor; n=2; ... 134 1e-29
UniRef50_Q9UM73 Cluster: ALK tyrosine kinase receptor precursor;... 134 1e-29
UniRef50_Q8JFV0 Cluster: Tyrosine-protein kinase receptor; n=5; ... 134 1e-29
UniRef50_Q9VZI2 Cluster: CG14992-PA; n=3; Sophophora|Rep: CG1499... 134 1e-29
UniRef50_Q9BL77 Cluster: C-terminal src kinase protein 1; n=2; C... 134 1e-29
UniRef50_Q4L0H7 Cluster: Insulin receptor tyrosine kinase; n=2; ... 134 1e-29
UniRef50_P24348 Cluster: Receptor tyrosine-protein kinase let-23... 134 1e-29
UniRef50_P08630 Cluster: Tyrosine-protein kinase Btk29A; n=10; E... 134 1e-29
UniRef50_UPI0000D56EE8 Cluster: PREDICTED: similar to CG14992-PA... 134 2e-29
UniRef50_UPI00015A3FB5 Cluster: hypothetical protein LOC553690; ... 133 2e-29
UniRef50_Q16UV1 Cluster: Protein kinase protein; n=3; Culicidae|... 133 2e-29
UniRef50_Q573B4 Cluster: Proto-oncogene tyrosine-protein kinase ... 133 2e-29
UniRef50_UPI0000E4736E Cluster: PREDICTED: similar to src-family... 133 3e-29
UniRef50_Q9I9L1 Cluster: Arg protein-tyrosine kinase; n=12; Tetr... 133 3e-29
UniRef50_Q9V4E5 Cluster: CG1511-PC, isoform C; n=12; Diptera|Rep... 133 3e-29
UniRef50_Q9GRH1 Cluster: Tyrosine-protein kinase receptor; n=4; ... 133 3e-29
UniRef50_O76997 Cluster: Putative neurotrophin receptor LTRK 1 p... 133 3e-29
UniRef50_UPI0000F1FB23 Cluster: PREDICTED: similar to tyrosine p... 132 4e-29
UniRef50_Q27324 Cluster: Tyrosine-protein kinase Drl precursor; ... 132 4e-29
UniRef50_UPI000051AB92 Cluster: PREDICTED: similar to Fak-like t... 132 5e-29
UniRef50_UPI000065E2FA Cluster: Homolog of Homo sapiens "Tyrosin... 132 5e-29
UniRef50_Q5G254 Cluster: Erbb3; n=6; Danio rerio|Rep: Erbb3 - Da... 132 5e-29
UniRef50_A0JMM7 Cluster: Zgc:154019; n=2; Danio rerio|Rep: Zgc:1... 132 5e-29
UniRef50_Q21867 Cluster: Putative uncharacterized protein; n=2; ... 132 5e-29
UniRef50_Q8NFA8 Cluster: Transmembrane receptor PTK7-2; n=18; Eu... 132 5e-29
UniRef50_Q13308 Cluster: Tyrosine-protein kinase-like 7 precurso... 132 5e-29
UniRef50_Q5MCM8 Cluster: Protein-tyrosine kinase; n=2; Anthomedu... 132 7e-29
UniRef50_Q01974 Cluster: Tyrosine-protein kinase transmembrane r... 132 7e-29
UniRef50_Q01973 Cluster: Tyrosine-protein kinase transmembrane r... 132 7e-29
UniRef50_P21709 Cluster: Ephrin type-A receptor 1 precursor; n=1... 132 7e-29
UniRef50_Q66I04 Cluster: Zgc:92124; n=1; Danio rerio|Rep: Zgc:92... 131 9e-29
UniRef50_Q7YZH5 Cluster: MBTK3; n=1; Monosiga brevicollis|Rep: M... 131 9e-29
UniRef50_O16131 Cluster: Insulin receptor homolog precursor; n=2... 131 9e-29
UniRef50_UPI0000D563AD Cluster: PREDICTED: similar to CG3969-PA,... 131 1e-28
UniRef50_Q4RY69 Cluster: Chromosome 3 SCAF14978, whole genome sh... 131 1e-28
UniRef50_Q2VXS7 Cluster: Proto-oncogene c-fes variant 4; n=77; E... 131 1e-28
UniRef50_P51813 Cluster: Cytoplasmic tyrosine-protein kinase BMX... 131 1e-28
UniRef50_Q4SF69 Cluster: Chromosome undetermined SCAF14608, whol... 130 2e-28
UniRef50_Q9Y1X8 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 130 2e-28
UniRef50_Q8T6F8 Cluster: SRC-1; n=3; Caenorhabditis|Rep: SRC-1 -... 130 2e-28
UniRef50_UPI00015B4221 Cluster: PREDICTED: similar to tyrosine-p... 130 2e-28
UniRef50_UPI0000F1EB7D Cluster: PREDICTED: hypothetical protein;... 130 2e-28
UniRef50_UPI0000E47C0F Cluster: PREDICTED: similar to focal adhe... 130 2e-28
UniRef50_UPI0000DB7330 Cluster: PREDICTED: similar to Ack CG1499... 130 2e-28
UniRef50_Q4S1M5 Cluster: Chromosome 6 SCAF14768, whole genome sh... 130 2e-28
UniRef50_Q8WPV5 Cluster: Tyrosine kinase; n=2; Eumetazoa|Rep: Ty... 130 2e-28
UniRef50_Q7Z1D3 Cluster: Focal adhesion kinase; n=1; Lytechinus ... 130 2e-28
UniRef50_Q17PG3 Cluster: Tyrosine-protein kinase drl; n=5; Endop... 130 2e-28
UniRef50_Q24592 Cluster: Tyrosine-protein kinase hopscotch; n=2;... 130 2e-28
UniRef50_UPI0000E470E3 Cluster: PREDICTED: similar to Fer, parti... 129 4e-28
UniRef50_P29317 Cluster: Ephrin type-A receptor 2 precursor; n=3... 129 4e-28
UniRef50_UPI00015B5A01 Cluster: PREDICTED: similar to protein ki... 129 5e-28
UniRef50_UPI0000D577C3 Cluster: PREDICTED: similar to CG8874-PB,... 129 5e-28
UniRef50_UPI0000D5603D Cluster: PREDICTED: similar to Insulin re... 129 5e-28
UniRef50_Q4SFJ9 Cluster: Chromosome 7 SCAF14601, whole genome sh... 129 5e-28
UniRef50_UPI0000D56AE3 Cluster: PREDICTED: similar to CG1594-PA;... 128 7e-28
UniRef50_Q98TD0 Cluster: Ephrin receptor; n=6; Amniota|Rep: Ephr... 128 7e-28
UniRef50_Q7YZW6 Cluster: Putative uncharacterized protein; n=3; ... 128 7e-28
UniRef50_Q0PDJ5 Cluster: Protein tyrosine kinase CSK; n=1; Monos... 128 7e-28
UniRef50_A7S4Y9 Cluster: Predicted protein; n=1; Nematostella ve... 128 7e-28
UniRef50_P16591 Cluster: Proto-oncogene tyrosine-protein kinase ... 128 7e-28
UniRef50_Q13470 Cluster: Non-receptor tyrosine-protein kinase TN... 128 9e-28
UniRef50_UPI00015A61DF Cluster: UPI00015A61DF related cluster; n... 128 1e-27
UniRef50_Q4SS18 Cluster: Chromosome undetermined SCAF14482, whol... 128 1e-27
UniRef50_Q4SQ14 Cluster: Tyrosine-protein kinase receptor; n=1; ... 128 1e-27
UniRef50_Q5D184 Cluster: Ephrin receptor; n=2; Apocrita|Rep: Eph... 128 1e-27
UniRef50_Q52V39 Cluster: Tyrosine-protein kinase receptor; n=2; ... 128 1e-27
UniRef50_Q17JW1 Cluster: Tyrosine protein kinase; n=2; Culicidae... 128 1e-27
UniRef50_P42686 Cluster: Tyrosine-protein kinase isoform SRK1; n... 128 1e-27
UniRef50_UPI0000E47068 Cluster: PREDICTED: similar to tyrosine p... 127 2e-27
UniRef50_Q4SFK0 Cluster: Chromosome 7 SCAF14601, whole genome sh... 127 2e-27
UniRef50_Q21868 Cluster: Putative uncharacterized protein; n=1; ... 127 2e-27
UniRef50_UPI0000E468FC Cluster: PREDICTED: similar to KLG; n=3; ... 127 2e-27
UniRef50_Q4RXV8 Cluster: Chromosome 11 SCAF14979, whole genome s... 127 2e-27
UniRef50_Q6TYB9 Cluster: Dauer abnormal formation-2 precursor; n... 127 2e-27
UniRef50_O76411 Cluster: Suppressor of constitutive dauer format... 127 2e-27
UniRef50_A1IKE0 Cluster: Receptor tyrosine kinase-like orphan re... 127 2e-27
UniRef50_Q14289 Cluster: Protein tyrosine kinase 2 beta; n=47; E... 127 2e-27
UniRef50_P51451 Cluster: Tyrosine-protein kinase BLK; n=5; Eutel... 127 2e-27
UniRef50_Q5RIU8 Cluster: Novel protein similar to vertebrate dis... 126 3e-27
UniRef50_Q6PFV6 Cluster: Ephrin receptor; n=11; Tetrapoda|Rep: E... 126 4e-27
UniRef50_Q9N3S5 Cluster: Putative uncharacterized protein; n=4; ... 126 4e-27
UniRef50_Q96HF4 Cluster: EPHA2 protein; n=3; Amniota|Rep: EPHA2 ... 126 4e-27
UniRef50_P43403 Cluster: Tyrosine-protein kinase ZAP-70; n=55; E... 126 4e-27
UniRef50_Q08345 Cluster: Epithelial discoidin domain-containing ... 126 4e-27
UniRef50_Q4RQT4 Cluster: Chromosome 2 SCAF15004, whole genome sh... 126 5e-27
UniRef50_Q7JQT0 Cluster: GH27039p; n=4; Diptera|Rep: GH27039p - ... 126 5e-27
UniRef50_UPI0000F1F8B4 Cluster: PREDICTED: hypothetical protein;... 125 6e-27
UniRef50_Q4SII9 Cluster: Chromosome 5 SCAF14581, whole genome sh... 125 6e-27
UniRef50_Q7QAK4 Cluster: ENSANGP00000020257; n=1; Anopheles gamb... 125 6e-27
UniRef50_P54756 Cluster: Ephrin type-A receptor 5 precursor; n=1... 125 6e-27
UniRef50_UPI0000D576E5 Cluster: PREDICTED: similar to CG33531-PA... 125 8e-27
UniRef50_Q4SQX3 Cluster: Chromosome 11 SCAF14528, whole genome s... 125 8e-27
UniRef50_Q9Y1Y0 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 125 8e-27
UniRef50_O76978 Cluster: Tyrosine kinase; n=1; Sycon raphanus|Re... 125 8e-27
UniRef50_UPI0000DB7735 Cluster: PREDICTED: similar to Insulin re... 124 1e-26
UniRef50_UPI00006A0D3B Cluster: Tyrosine protein-kinase STYK1 (E... 124 1e-26
UniRef50_Q9Y1Y4 Cluster: Tyrosine-protein kinase; n=1; Ephydatia... 124 1e-26
UniRef50_Q9V422 Cluster: Tyrosine-protein kinase Dnt precursor; ... 124 1e-26
UniRef50_P43405 Cluster: Tyrosine-protein kinase SYK; n=23; Ther... 124 1e-26
UniRef50_Q4RV12 Cluster: Ephrin receptor; n=2; Tetraodontidae|Re... 124 1e-26
UniRef50_Q4RQ50 Cluster: Chromosome 17 SCAF15006, whole genome s... 124 1e-26
UniRef50_Q08BY6 Cluster: Zgc:153964; n=3; Danio rerio|Rep: Zgc:1... 124 1e-26
UniRef50_Q6SAX5 Cluster: Epidermal growth factor receptor; n=14;... 124 1e-26
UniRef50_P42687 Cluster: Tyrosine-protein kinase SPK-1; n=1; Gir... 124 1e-26
UniRef50_Q13882 Cluster: Tyrosine-protein kinase 6; n=11; Mammal... 124 1e-26
UniRef50_Q15375 Cluster: Ephrin type-A receptor 7 precursor; n=5... 124 1e-26
UniRef50_Q9Y1Y6 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 124 2e-26
UniRef50_Q9GRH2 Cluster: Tyrosine-protein kinase receptor; n=1; ... 124 2e-26
UniRef50_Q4H3M5 Cluster: Ephrin receptor; n=1; Ciona intestinali... 124 2e-26
UniRef50_Q15516 Cluster: Tyrosine kinase; n=1; Homo sapiens|Rep:... 124 2e-26
UniRef50_Q9UF33 Cluster: Ephrin type-A receptor 6 precursor; n=5... 124 2e-26
UniRef50_UPI0000E47617 Cluster: PREDICTED: similar to muscle spe... 123 2e-26
UniRef50_Q4RXA0 Cluster: Chromosome 11 SCAF14979, whole genome s... 123 2e-26
UniRef50_Q6VU50 Cluster: Eph receptor; n=3; Endopterygota|Rep: E... 123 2e-26
UniRef50_Q4SWL0 Cluster: Ephrin receptor; n=3; Tetraodontidae|Re... 123 3e-26
UniRef50_Q4H3A3 Cluster: Janus kinase; n=1; Ciona intestinalis|R... 123 3e-26
UniRef50_UPI0000E257E1 Cluster: PREDICTED: similar to tyrosine k... 122 4e-26
UniRef50_UPI00006A1E7A Cluster: Non-receptor tyrosine-protein ki... 122 4e-26
UniRef50_Q5IJ68 Cluster: Trk-like receptor tyrosine kinase; n=1;... 122 4e-26
UniRef50_P29322 Cluster: Ephrin type-A receptor 8 precursor; n=2... 122 4e-26
UniRef50_Q4SMF1 Cluster: Chromosome 8 SCAF14552, whole genome sh... 122 6e-26
UniRef50_Q7PT15 Cluster: ENSANGP00000009263; n=2; Culicidae|Rep:... 122 6e-26
UniRef50_O76698 Cluster: Vegf (Vascular endothelial growth facto... 122 6e-26
UniRef50_UPI00015B6067 Cluster: PREDICTED: similar to tyrosine p... 122 8e-26
UniRef50_UPI0000DB7B4C Cluster: PREDICTED: similar to hopscotch ... 122 8e-26
UniRef50_UPI00006A1DD3 Cluster: UPI00006A1DD3 related cluster; n... 122 8e-26
UniRef50_Q24327 Cluster: Gp160-Dtrk precursor; n=4; Sophophora|R... 122 8e-26
UniRef50_UPI00015B6363 Cluster: PREDICTED: similar to tyrosine p... 121 1e-25
UniRef50_A2CG59 Cluster: Eph receptor B1; n=23; Euteleostomi|Rep... 121 1e-25
UniRef50_Q6SAW1 Cluster: Epidermal growth factor receptor; n=70;... 121 1e-25
UniRef50_P21860 Cluster: Receptor tyrosine-protein kinase erbB-3... 121 1e-25
UniRef50_Q9PTN6 Cluster: Tyrosine-protein kinase; n=9; Euteleost... 121 1e-25
UniRef50_Q60I21 Cluster: TEC family protein tyrosine kinase; n=1... 120 2e-25
UniRef50_Q7YSY1 Cluster: Fes-like tyrosine kinase protein; n=1; ... 120 2e-25
UniRef50_O45232 Cluster: Putative uncharacterized protein ark-1;... 120 2e-25
UniRef50_Q70W12 Cluster: Discoidin receptor; n=1; Ciona intestin... 120 2e-25
UniRef50_Q61BE2 Cluster: Putative uncharacterized protein CBG133... 120 2e-25
UniRef50_UPI0000DB6B52 Cluster: PREDICTED: similar to Ror CG4926... 120 3e-25
UniRef50_UPI00015A7C25 Cluster: UPI00015A7C25 related cluster; n... 120 3e-25
UniRef50_P79884 Cluster: Insulin-like growth factor-I receptor; ... 120 3e-25
UniRef50_UPI000069DB6A Cluster: Ephrin type-A receptor 6 precurs... 119 4e-25
UniRef50_UPI000065E56D Cluster: EPHB1_HUMAN Isoform 3 of P54762 ... 119 4e-25
UniRef50_UPI0000ECD739 Cluster: Cytoplasmic tyrosine-protein kin... 119 5e-25
UniRef50_Q4S6E0 Cluster: Chromosome 10 SCAF14728, whole genome s... 119 5e-25
UniRef50_Q68KJ7 Cluster: HER2; n=3; Amniota|Rep: HER2 - Felis si... 119 5e-25
UniRef50_P52333 Cluster: Tyrosine-protein kinase JAK3; n=17; Eut... 119 5e-25
UniRef50_Q16832 Cluster: Discoidin domain-containing receptor 2 ... 119 5e-25
UniRef50_P07947 Cluster: Proto-oncogene tyrosine-protein kinase ... 118 7e-25
UniRef50_Q4SP88 Cluster: Ephrin receptor; n=2; Tetraodon nigrovi... 118 9e-25
UniRef50_Q4SC90 Cluster: Chromosome undetermined SCAF14659, whol... 118 9e-25
UniRef50_Q4RPK6 Cluster: Chromosome 12 SCAF15007, whole genome s... 118 9e-25
UniRef50_UPI000065F647 Cluster: Ephrin type-B receptor 2 precurs... 118 1e-24
UniRef50_Q0P4R9 Cluster: Discoidin domain receptor family, membe... 118 1e-24
UniRef50_Q4H3M3 Cluster: Ephrin receptor like protein; n=1; Cion... 118 1e-24
UniRef50_UPI0000E49042 Cluster: PREDICTED: similar to RE05926p; ... 117 2e-24
UniRef50_Q9XZ66 Cluster: Tyrosine kinase receptor-related protei... 117 2e-24
UniRef50_Q17842 Cluster: Putative uncharacterized protein; n=1; ... 117 2e-24
UniRef50_P29323 Cluster: Ephrin type-B receptor 2 precursor; n=3... 117 2e-24
UniRef50_UPI0000E48069 Cluster: PREDICTED: hypothetical protein;... 117 2e-24
UniRef50_UPI00006A26D5 Cluster: UPI00006A26D5 related cluster; n... 117 2e-24
UniRef50_A7SP77 Cluster: Predicted protein; n=1; Nematostella ve... 117 2e-24
UniRef50_Q95ZV7 Cluster: Putative uncharacterized protein; n=3; ... 116 3e-24
UniRef50_Q61BE3 Cluster: Putative uncharacterized protein CBG133... 116 3e-24
UniRef50_Q6J9G0 Cluster: Tyrosine protein-kinase STYK1; n=20; Am... 116 4e-24
UniRef50_O60674 Cluster: Tyrosine-protein kinase JAK2; n=48; Eut... 116 4e-24
UniRef50_P18106 Cluster: Tyrosine-protein kinase Fps85D; n=12; E... 116 4e-24
UniRef50_UPI0000660568 Cluster: Ephrin type-B receptor 2 precurs... 116 5e-24
UniRef50_Q9Y1Y1 Cluster: Protein tyrosine kinase; n=2; cellular ... 116 5e-24
UniRef50_Q4H3M4 Cluster: Ephrin receptor; n=2; Ciona intestinali... 116 5e-24
UniRef50_A7SFD8 Cluster: Predicted protein; n=2; Nematostella ve... 116 5e-24
UniRef50_UPI00004D86FC Cluster: Tyrosine-protein kinase Tec (EC ... 115 7e-24
UniRef50_UPI0000F202EE Cluster: PREDICTED: similar to LCK2; n=2;... 115 9e-24
UniRef50_Q4TEC1 Cluster: Chromosome undetermined SCAF5507, whole... 115 9e-24
UniRef50_Q4T272 Cluster: Chromosome undetermined SCAF10323, whol... 115 9e-24
UniRef50_Q5JZY3 Cluster: Ephrin type-A receptor 10 precursor; n=... 115 9e-24
UniRef50_P23458 Cluster: Tyrosine-protein kinase JAK1; n=55; Eut... 114 2e-23
UniRef50_UPI0000E47549 Cluster: PREDICTED: similar to Cek8; n=2;... 113 2e-23
UniRef50_UPI0000DB74F2 Cluster: PREDICTED: similar to Derailed 2... 113 4e-23
UniRef50_UPI000065F9C5 Cluster: Epithelial discoidin domain-cont... 113 4e-23
UniRef50_Q4TFI7 Cluster: Chromosome undetermined SCAF4439, whole... 113 4e-23
UniRef50_A0NAP9 Cluster: ENSANGP00000018250; n=2; Anopheles gamb... 112 6e-23
UniRef50_UPI0000D560EA Cluster: PREDICTED: similar to CG31127-PA... 111 1e-22
UniRef50_UPI00005A2D48 Cluster: PREDICTED: similar to EPH recept... 111 1e-22
UniRef50_UPI0000519EF1 Cluster: PREDICTED: similar to CG31640-PA... 110 2e-22
UniRef50_Q23554 Cluster: Putative uncharacterized protein; n=1; ... 110 2e-22
UniRef50_A7T8I7 Cluster: Predicted protein; n=1; Nematostella ve... 110 2e-22
UniRef50_A7RWY4 Cluster: Predicted protein; n=1; Nematostella ve... 110 2e-22
UniRef50_UPI0000D55944 Cluster: PREDICTED: similar to CG8967-PA;... 109 4e-22
UniRef50_Q7PMY4 Cluster: ENSANGP00000014155; n=2; Culicidae|Rep:... 109 4e-22
UniRef50_UPI0000E47A46 Cluster: PREDICTED: similar to ret protei... 109 6e-22
UniRef50_Q9Y1X7 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 109 6e-22
UniRef50_Q0MQ66 Cluster: Putative uncharacterized protein; n=5; ... 109 6e-22
UniRef50_UPI00015B46B5 Cluster: PREDICTED: similar to CG33531-PA... 107 1e-21
UniRef50_Q9PWD1 Cluster: Tyrosine-protein kinase; n=3; Tetraodon... 107 1e-21
UniRef50_Q23136 Cluster: Putative uncharacterized protein; n=2; ... 107 1e-21
UniRef50_Q25198 Cluster: Receptor tyrosine kinase 90; n=1; Hydra... 107 2e-21
UniRef50_Q95YD4 Cluster: Protein kinase protein 32, isoform a; n... 107 2e-21
UniRef50_UPI000155CF4D Cluster: PREDICTED: similar to EPH recept... 106 4e-21
UniRef50_Q16LR4 Cluster: Tyrosine protein kinase; n=5; Coelomata... 106 4e-21
UniRef50_UPI00015B55E2 Cluster: PREDICTED: similar to tyrosine-p... 105 5e-21
UniRef50_Q52ZF0 Cluster: Receptor tyrosine kinase-like protein; ... 105 5e-21
UniRef50_Q1LUT7 Cluster: Novel protein similar to vertebrate ser... 105 7e-21
UniRef50_Q27HR1 Cluster: Ret tyrosine-kinase receptor; n=1; Bran... 105 7e-21
UniRef50_Q16RU6 Cluster: Mitogen-activated protein kinase kinase... 105 7e-21
UniRef50_Q12852 Cluster: Mitogen-activated protein kinase kinase... 105 7e-21
UniRef50_UPI0000DB7B8A Cluster: PREDICTED: similar to CG8789-PA,... 105 9e-21
UniRef50_Q259N0 Cluster: H0723C07.13 protein; n=4; Oryza sativa|... 105 9e-21
UniRef50_Q0DDD4 Cluster: Os06g0232100 protein; n=5; Oryza sativa... 104 1e-20
UniRef50_A2YAZ9 Cluster: Putative uncharacterized protein; n=1; ... 104 1e-20
UniRef50_A7RL50 Cluster: Predicted protein; n=1; Nematostella ve... 104 1e-20
UniRef50_UPI0000DB6C79 Cluster: PREDICTED: similar to PTK7 prote... 103 2e-20
UniRef50_UPI0000499A85 Cluster: protein kinase; n=1; Entamoeba h... 103 2e-20
UniRef50_UPI0000F1FDC5 Cluster: PREDICTED: similar to ENSANGP000... 103 3e-20
UniRef50_Q9Y1Z6 Cluster: Protein tyrosine kinase 13; n=1; Hydra ... 103 3e-20
UniRef50_Q10915 Cluster: Putative uncharacterized protein; n=2; ... 103 4e-20
UniRef50_P34265 Cluster: Probable tyrosine-protein kinase kin-31... 103 4e-20
UniRef50_Q4S5N1 Cluster: Chromosome 9 SCAF14729, whole genome sh... 102 5e-20
UniRef50_Q1SMZ9 Cluster: Protein kinase; n=3; Viridiplantae|Rep:... 102 5e-20
UniRef50_Q9Y1Z4 Cluster: Protein tyrosine kinase 37; n=1; Hydra ... 102 5e-20
UniRef50_A2FI59 Cluster: TKL family protein kinase; n=1; Trichom... 102 5e-20
UniRef50_A2DXP4 Cluster: TKL family protein kinase; n=1; Trichom... 102 5e-20
UniRef50_UPI0000D55A9B Cluster: PREDICTED: similar to CG8789-PA,... 102 7e-20
UniRef50_Q9XX42 Cluster: Putative uncharacterized protein; n=2; ... 102 7e-20
UniRef50_Q8WSM2 Cluster: Receptor tyrosine kinase; n=1; Schistos... 102 7e-20
UniRef50_Q9GJZ9 Cluster: Flk-type VEGF receptor; n=6; Deuterosto... 101 9e-20
UniRef50_UPI0000DB7238 Cluster: PREDICTED: similar to Discoidin ... 101 1e-19
UniRef50_Q8LPH3 Cluster: MAP kinase, putative; n=8; Brassicaceae... 101 1e-19
UniRef50_Q9VW24 Cluster: CG8789-PA, isoform A; n=3; Diptera|Rep:... 101 1e-19
UniRef50_UPI00015B629F Cluster: PREDICTED: similar to CG33531-PA... 101 2e-19
UniRef50_UPI0000F1D883 Cluster: PREDICTED: hypothetical protein;... 101 2e-19
UniRef50_Q00Y29 Cluster: Protein kinase family protein; n=1; Ost... 101 2e-19
UniRef50_UPI000065D8B4 Cluster: Basic fibroblast growth factor r... 100 2e-19
UniRef50_Q59DZ7 Cluster: CG33531-PA; n=6; Sophophora|Rep: CG3353... 100 2e-19
UniRef50_O02064 Cluster: Putative uncharacterized protein; n=1; ... 100 3e-19
>UniRef50_UPI00015B5C00 Cluster: PREDICTED: similar to VEGFR-A splice
form A; n=1; Nasonia vitripennis|Rep: PREDICTED: similar
to VEGFR-A splice form A - Nasonia vitripennis
Length = 1294
Score = 544 bits (1343), Expect = e-153
Identities = 304/709 (42%), Positives = 424/709 (59%), Gaps = 43/709 (6%)
Query: 432 APIIREPDSNKDEEAMEGR----SIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDI 487
AP + N E + GR ++ L C A G+P+P I WYKDDE + N + F
Sbjct: 523 APYFTYVNMNGSEVTIAGREAYNNLHLICRAGGMPKPHITWYKDDEPLKFNE--EQF--- 577
Query: 488 VNHTIVNSTFEIENMQEKDNGIYECVALNNASELRRAYTLVLKAEKSYTPYXXXXXXXXX 547
+ S I + EKD+G Y CVA N + + +++K + +
Sbjct: 578 --YLSSESELVIRFLMEKDSGKYSCVAENRVGKETQFQKILVKGTEVSMMWMLTIVILLI 635
Query: 548 XXXGMVAYLFTWKLKKQR----ELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFE 603
+ Y F K++++R +L +AGL++F+ G NP L +D+QA+LLPYD+K+E
Sbjct: 636 VLIALSIY-FCIKIRRERSMRKQLVEAGLIHFEEGALDCINPELTVDDQAELLPYDKKWE 694
Query: 604 FPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKI 663
FPREKL GKQLG+GAFGVV KAEARGI+ E T VAVKMV+R A+ YI+ALASELKI
Sbjct: 695 FPREKLKLGKQLGSGAFGVVMKAEARGIVADESLTTVAVKMVRRNAEPAYIRALASELKI 754
Query: 664 MVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQL---TDNA 720
MVHLGKH+N+VNLLGACT +IAKREL+VIVEYC+YGN+HNY+ +HR FI+Q+ T
Sbjct: 755 MVHLGKHLNVVNLLGACTNNIAKRELLVIVEYCRYGNLHNYLLRHRANFINQIDPVTGQI 814
Query: 721 EKNLGKINKGFLNSVGTTGTHSDYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYI----- 775
+ N+G+ + + S T +S +SGN+ +++Y ++K G I
Sbjct: 815 DPNIGQ--ELLMRSTSVTSNNSLSAASGNSAPGTETVIYCTDTKDVTGIPDAGCINSNGS 872
Query: 776 QQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLAD 835
Q W++ Y GDY + +P+ + LL WAFQ+ARGMEYL RKVLHGDLAARN+LLA+
Sbjct: 873 QPGWRSNYRGDY--KDRNLKPICTQDLLSWAFQVARGMEYLCQRKVLHGDLAARNILLAE 930
Query: 836 DNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEM 895
+NVVKICDFGLA++MY N+ Y+K+ + P+P+KW+AIE + D IFSTQSD+WS+GIVLWE
Sbjct: 931 NNVVKICDFGLAKTMYKNDNYKKQGDGPVPIKWMAIESIRDWIFSTQSDIWSFGIVLWEF 990
Query: 896 FSLAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEI 955
F+LA+TPYP + + L +G R+E+P +A +Y+ ML+CW KPT RPSFTEL E
Sbjct: 991 FTLAETPYPGMQAEKQYQKLIEGYRMEQPKYATKAIYDTMLQCWKAKPTLRPSFTELVEN 1050
Query: 956 LGNFLEDNERNRYVDLNAPYNEMNAELMTG-EDYLAMVCAPDYNNIV-TPSPNYVNMAKS 1013
+G LE+ R YVDLN PY +MN + G +DYL M+ APD+ ++ +P YVN
Sbjct: 1051 IGELLEEGVRMHYVDLNTPYLDMNTAGLEGKDDYLTMMSAPDHAILMASPEHEYVN---- 1106
Query: 1014 FFPATPTPKDQEGYLPM-SPTSDQTKYMAHGTKFDFDSRKLNPRVSEASNVGSVITPLLD 1072
P P D YL M SP D++ + D +SR P S + + D
Sbjct: 1107 ---GPPQPTD-SAYLSMNSPALDESGIFSPRPNED-NSRFQFPNSPSTSIANAAHS---D 1158
Query: 1073 LNNLPARSGSESDHENNASTYLDKCIDDKKSDEVFEMKQTNTKNPQDNS 1121
+ P ++ + E + YL KK +E ++ K ++ S
Sbjct: 1159 GEDAPMLKKTKEEPEQDEDNYLKPIDVHKKREEFMRQREAEKKKERERS 1207
Score = 95.5 bits (227), Expect = 8e-18
Identities = 106/442 (23%), Positives = 181/442 (40%), Gaps = 33/442 (7%)
Query: 13 IVIECRPTTPDVNVTLSSEIPDYYYP---SFRYSPKIGFVPENSMPSDDQIISFVLCEFV 69
I++ CRPT+ +++V L SE + + P++GF EN D CE
Sbjct: 36 IILPCRPTSKELHVQLKSETEMEEMELNENLSFDPRVGFRMENLSALDSNTY---FCEIE 92
Query: 70 RGETRIEKYIYVSKHIKKPP--KPKVA-GGHKQFLEGETFTIHCRVPN--DGLINFKWKY 124
T E ++ K I+K P + G + +G + + C V D +F W
Sbjct: 93 HNGTT-ETLTFLVKLIQKSTLKTPVILKDGLEYVTKGSSLHVKCTVTIGIDNNFDFYWTT 151
Query: 125 PPEVTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEKDEFRKI 184
P ++ ++ V + T +V + N T G Y C + + + K I
Sbjct: 152 PRNSSSRTIRPPVRRRIEANT-QLVTSELVEENVTYDDEGEYVCKVKSLT-DMKSTSTYI 209
Query: 185 FLEKP---FLSLRDLAKGK-LMGNANKSINIVIEIEAYPPVERTHFLKNDKYLPSNDLKY 240
+ P +++L K + + NA KS+ E++ YP + K + SN+ +
Sbjct: 210 RVHDPSIKYINLTSHDKDRHYVINAFKSVTFSAEVKGYPTPSIMWLSPDGKEILSNN-RI 268
Query: 241 NVTTLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAKLLNNRIIKR 300
V N L+I +++ D+ Y L A N ++ L V +P A L
Sbjct: 269 TVEN-KNSSTTLKIQSVEIRDMGTYLLQAFNDDKEEHLNFTLEVLARPLAILRPVEHYYV 327
Query: 301 LENSEMNFACKVTGYPLPDVTWIF---------SNDEEHELSSTKSEQESLYAKTDYLKI 351
L N +F CK G P +++W + E+ EL + +ES T ++
Sbjct: 328 L-NERASFGCKAVGNPTSNMSWAYFKCPNLPSEEGCEKVELEDARILEESGSMITGEVEA 386
Query: 352 SVQASGVITCNAHNSKGEYFDSSTLLVYE--INNGFGILQPLENWYSEKDSARKKCLASV 409
+++ SG I C A N G +LV + + GI++P E + D C AS+
Sbjct: 387 TIEMSGRIKCTACNRLGCDSSEQNVLVSDGVPDTALGIIEPEEK-ITAGDDVVVTCAASI 445
Query: 410 YDYDNVSWLGSDGNILDDIELL 431
Y++ V WL ++ L D + L
Sbjct: 446 YNFTTVEWLDANEEPLQDSQRL 467
Score = 39.1 bits (87), Expect = 0.69
Identities = 25/84 (29%), Positives = 45/84 (53%), Gaps = 8/84 (9%)
Query: 450 RSIQLHCEAEGVPRPTIYWYKDD--ELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDN 507
+S+ E +G P P+I W D E++SNN ++ V+ N ++T +I++++ +D
Sbjct: 236 KSVTFSAEVKGYPTPSIMWLSPDGKEILSNN---RITVENKNS---STTLKIQSVEIRDM 289
Query: 508 GIYECVALNNASELRRAYTLVLKA 531
G Y A N+ E +TL + A
Sbjct: 290 GTYLLQAFNDDKEEHLNFTLEVLA 313
>UniRef50_Q8T4M0 Cluster: VEGFR-A splice form A; n=4; Diptera|Rep:
VEGFR-A splice form A - Drosophila melanogaster (Fruit
fly)
Length = 1474
Score = 487 bits (1201), Expect = e-136
Identities = 283/694 (40%), Positives = 407/694 (58%), Gaps = 51/694 (7%)
Query: 450 RSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVN-STFEIENMQEKDNG 508
++++L C + VP + W+KDD+ ++ + + H I S I ++ D G
Sbjct: 711 QTLELECASTAVPVAIVRWFKDDKEVTESK--------LRHIIEKESKLLITHLYPGDEG 762
Query: 509 IYECVALNNASELRRAYTLVLKAEKSYT-PYXXXXXXXXXXXXGMVAYL---FTWKLKKQ 564
+Y+CV N + R++T+V+ + + G+ +L + + K+
Sbjct: 763 VYKCVVENRLDRIERSFTVVISDLPGISMAWVWFGVILFLILIGLCVFLAVRYQKEHKRH 822
Query: 565 RELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVY 624
L AGL NF+ G NP+L +DEQA+LLPY+ +FEFPRE L GKQLGAGAFGVV
Sbjct: 823 LALKAAGLANFEEGAVGHINPDLTLDEQAELLPYNREFEFPRENLKLGKQLGAGAFGVVL 882
Query: 625 KAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHI 684
K EA+GI E TT VAVKMVK TADN ++AL SELKIMVHLG+H+N+VNLLGA TK+I
Sbjct: 883 KGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNI 942
Query: 685 AKRELIVIVEYCKYGNIHNYMQKHREVFIDQL----------------TDNAEKNLGKIN 728
AKREL+VIVEYC++GNI N++ ++R+ FI+Q+ +DN E + N
Sbjct: 943 AKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIITQRMSDNYELHRNSDN 1002
Query: 729 KGFLNS-VGTTGTHSDYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQEWQTKYEGDY 787
+ G TG+ + +S DT +++ + + +S +Q W++ Y+ D
Sbjct: 1003 DPRSGTRAGRTGSGTATYSYDRQMDTCATVMTT--VPEDDQIMSNNSVQPAWRSNYKTDS 1060
Query: 788 IYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLA 847
+ +T+ L+ WAFQ+ARGM+YL+++KVLHGDLAARN+LL +DNVVKICDFGLA
Sbjct: 1061 T----EAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLA 1116
Query: 848 RSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS 907
RSMY + Y+K EN LP+KWLA+E + D +FST SDVWSYGIVLWEMFSLAK PYP I
Sbjct: 1117 RSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGID 1176
Query: 908 PT-DLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERN 966
P +L L+DG R+EKP FA+ LY +ML CW + P +RP F EL++ N L ++ +
Sbjct: 1177 PNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRFANMLGEDVAS 1236
Query: 967 RYVDLNAPYNEMNAELMTGE--DYLAMVCAPDYNNIVTPSPNYVNMAKSFFPATPTPKDQ 1024
+DLN PY + N E M + DYLA++ +PD + +P YVN P +
Sbjct: 1237 HCLDLNNPYMQSNIEYMKKQSTDYLALMGSPD--ELAPAAPRYVN--GHIVPDIRIEELP 1292
Query: 1025 EGYLPMSPTSDQTKYMA--HGTKFDFDSRKLNPRVSEAS-NV-GSVITPLLDLNNLPARS 1080
+ Y+ MS SD A T+ + +S SE + N G+ +P L NNL + S
Sbjct: 1293 DDYMEMSRDSDPDACTAIFSPTRLEGESSDFPDFSSETTFNFPGARQSPTLS-NNLNSGS 1351
Query: 1081 GSESDHENNASTYLDKCIDDKKSDEVFEMKQTNT 1114
+N T +D + D+ +E+ + +++T
Sbjct: 1352 SKPLRKKNGMPT-VD--VADQAPEEIPMLHRSST 1382
Score = 56.0 bits (129), Expect = 6e-06
Identities = 71/342 (20%), Positives = 137/342 (40%), Gaps = 26/342 (7%)
Query: 4 IVVPRDCSKIVIECRPTTPDVNVTLSSEIPDYYYPSF--RYSPKIGFVPE-NSMPSDDQI 60
+V R + +VI C+P PD V L + + + RY P+ GF E S+
Sbjct: 166 VVTARQYTDVVIPCKPAMPDTEVLLETSNGEMHSSKSVGRYDPQRGFTIEIRSIVDGGDY 225
Query: 61 ISFVLCEFVRGE---TRIE-KYI---YVSKHIKKPPKPKVAGGHKQFLEGET-FTIHCRV 112
F E T IE ++I ++ K K PKP + + + +T FT+ C
Sbjct: 226 YCRPNPPFPHNEEEMTSIEVRFIGNGHIDKDGKPLPKPVIRSSVEHHVFTDTNFTLDCEQ 285
Query: 113 PN--DGLINFKWKYPPEVTNDSVEVSVVKTEATTTGSIVY---QNITIRNATKKHNGVYT 167
+ + +W + P + + S +T+ T S +T+ NA G+Y
Sbjct: 286 SAYVESVYGMEW-FTPSRDENRIFASQSRTDPKTRNSTHQTGRSTLTVLNAQPSDTGLYK 344
Query: 168 CLLTNTCGE--EKDEFR-KIFLE-KPFLSLRD-LAKGKLMGNANKSINIVIEIEAYPPVE 222
C+ T+ + ++ +R K+ + + +L++ + + AN++I + E +P
Sbjct: 345 CVTTDNSNQNVQRATYRIKVLKQNESYLNVGEPSGHYNVQEYANRTIQMTANFEGFPTPS 404
Query: 223 RTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYTVDL 282
+ F + + ++ + + + L++ + +L D Y L N + ++
Sbjct: 405 FSWFKPDGTEVRQSENNFKILS-TELSTMLQVLNAQLQDSGTYVLRGSNSFGVVQREYNV 463
Query: 283 RVFTKPEAKLLNNRIIKRLENSEMNFACKVTGYPLPDVTWIF 324
V P K+ + + S C V YP VT+ F
Sbjct: 464 SVMDAPALKMSDAYV---QVGSVARLECTVRSYPPAIVTFFF 502
Score = 41.5 bits (93), Expect = 0.13
Identities = 23/95 (24%), Positives = 47/95 (49%), Gaps = 7/95 (7%)
Query: 435 IREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDD--ELISNNSGYKLFVDIVNHTI 492
+ EP + + + R+IQ+ EG P P+ W+K D E+ + + +K+ T
Sbjct: 374 VGEPSGHYNVQEYANRTIQMTANFEGFPTPSFSWFKPDGTEVRQSENNFKIL-----STE 428
Query: 493 VNSTFEIENMQEKDNGIYECVALNNASELRRAYTL 527
+++ ++ N Q +D+G Y N+ ++R Y +
Sbjct: 429 LSTMLQVLNAQLQDSGTYVLRGSNSFGVVQREYNV 463
>UniRef50_Q0IFX6 Cluster: Pdgf/vegf receptor; n=1; Aedes aegypti|Rep:
Pdgf/vegf receptor - Aedes aegypti (Yellowfever mosquito)
Length = 1101
Score = 473 bits (1165), Expect = e-131
Identities = 275/654 (42%), Positives = 378/654 (57%), Gaps = 51/654 (7%)
Query: 414 NVSWLGSDGNILDDIELLAPIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDE 473
N + D +L+ E AP+I + +++ E G C EG+P+P I W K+DE
Sbjct: 333 NSNEFDEDELMLEVYEPTAPVIVDEHVHEELEMEIGERNTFSCNVEGMPKPVIEWTKNDE 392
Query: 474 LISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIYECVALNNASELRRAYTLVLKA-- 531
+ +F + + N + + ++ +G Y C+A N ++ + ++L +K
Sbjct: 393 FV-------MFDNDTLVLLPNGSIHMPFLKVDLSGDYRCLARNKVAQAEKIWSLRVKTVT 445
Query: 532 -EKSYTPYXXXXXXXXXXXXGMVAYLFTWKLKKQRELTKAGLLNFKSGNKKSFNPNLGID 590
+K++ +++ + K K+ + + AG+ +F GN + NP L +D
Sbjct: 446 IKKTWVYLIISMILALVIAVVLISMFYCKKKKELKAMKAAGIEDFDKGNVEQMNPELALD 505
Query: 591 EQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTAD 650
EQADLLPY ++EFP+EKL GKQLGAGAFGVV KA A GI+ E T VAVKMVK+ D
Sbjct: 506 EQADLLPYKSEYEFPKEKLKLGKQLGAGAFGVVMKAIASGIMVNEDETVVAVKMVKKQTD 565
Query: 651 NMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHRE 710
N ++AL SELKIMVHLG+H+N+VNLLGA TK+IAKREL+VIVEYC++GN+ N++ KHR
Sbjct: 566 NEVMRALISELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNVQNFLLKHRP 625
Query: 711 VFIDQL-TDNAE--------------------KNLGKINKGFLNSVGTTGTHSD-----Y 744
FIDQ+ T+ E N K LNS G HS
Sbjct: 626 YFIDQVNTETGEIDSTIDTNKLRWSAAGYTYNSNSTAYPKNHLNSKGYV-RHSGIQNMAM 684
Query: 745 FSSGNTKDTDHSLL--YSGN-SKRSGRKVSEGYIQQE-WQTKYEGDYIYECHQPRPLTSG 800
S NT+ T + + Y N + + V+ G + W++ Y DY R +T+
Sbjct: 685 VDSCNTEATIMTSVDGYDLNTADTANNTVNSGNSNEPLWRSNYGMDY---KGPARAVTTT 741
Query: 801 HLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKE 860
L+ WA Q+A GMEYL +R+VLHGDLAARN+LL DDNVVKICDFGLARSMY +E Y+KK
Sbjct: 742 DLVCWASQVASGMEYLGSRRVLHGDLAARNILLCDDNVVKICDFGLARSMYKSENYKKKG 801
Query: 861 NSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPT-DLLRWLSDGN 919
+PLP KWLA+EC+ D +F T SDVW+YGIVLWE FSLA+ PYP + +L L DG
Sbjct: 802 EAPLPFKWLALECISDNVFGTYSDVWAYGIVLWEFFSLARVPYPGMEANQELYNKLRDGY 861
Query: 920 RLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLNAPYNEMN 979
R++KP +A+ +Y++ML CW+ KP +RPSF +L+ L + RN Y+DLN PY MN
Sbjct: 862 RMDKPQYANQDIYDIMLNCWNVKPDSRPSFKDLKSRFNAMLPEEMRNHYIDLNEPYLAMN 921
Query: 980 AEL-MTGE-DYLAMVCAPDYNNIVTPSPNYVNMAKSFFPATPTPKDQEGYLPMS 1031
AE GE DYLA + P+ P PNYVN P D+ YL M+
Sbjct: 922 AEKDQRGEPDYLASLGPPEGQAPKAP-PNYVN---GIILPLPPISDKPDYLQMT 971
Score = 51.2 bits (117), Expect = 2e-04
Identities = 69/297 (23%), Positives = 122/297 (41%), Gaps = 26/297 (8%)
Query: 152 NITIRNATKKHNGVYTCLLTNTCGEEKDEFRKIFLEKP----FLSLRDLAKGKLMGNANK 207
++TI A +G Y C +T+ + ++ + K F+ L D K + +K
Sbjct: 4 SLTINGALVSDSGYYQCEVTDHNSHSNHKSAQVHVVKQADIGFIELTDDNKLDFINITSK 63
Query: 208 -SINIVIEIEAYPPVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYT 266
I IVI+ +A E ++ ++D P + + N L I + D YT
Sbjct: 64 RDIKIVIKYKAVLQPE-FYWTRDDHPEPLEAGDHYSISETNQRITLTIKKSTIFDTGLYT 122
Query: 267 LVAENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRLENSEMNFACKVTGYPLPDVTWIF-- 324
L A+N+ Y + + V KP + N I R ++ F C YP P + + F
Sbjct: 123 LHAQNELNYTTYPMKVYVRDKPVVSI--NPIHAR-PGEKVTFVCTAIAYPQPAMRFAFIP 179
Query: 325 -----------SNDEEHELSSTKSEQESLYAKTDYLKISVQASGVITCNAHNSKGEYFDS 373
S +EH + + +S T+ ++ + +G + C A N GE F
Sbjct: 180 CTETPWKNCSKSLHKEH-VKHYEGGHQSDIITTEQYEMQAETAGYVGCLAVNGYGEDFVK 238
Query: 374 STLLVYEINNGFGI--LQPLENWYSEKDSARKKCLASVYDYDNVSWLGSDGNILDDI 428
+ LL+ +++ I L P E+ + D +C A VY++ + DG +L +
Sbjct: 239 ADLLISDLSKPVVIEKLSPDED-VTIGDEVTIECAAVVYNHTDAIDFFRDGVLLSGL 294
>UniRef50_UPI0000DB7A0A Cluster: PREDICTED: similar to FMS-like
tyrosine kinase 1; n=1; Apis mellifera|Rep: PREDICTED:
similar to FMS-like tyrosine kinase 1 - Apis mellifera
Length = 955
Score = 371 bits (912), Expect = e-101
Identities = 173/358 (48%), Positives = 243/358 (67%), Gaps = 7/358 (1%)
Query: 661 LKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDNA 720
LKIMVHLGKH+N+VNLLGAC + I+KREL+VIVEYC++GN+HNY+ +HR FI+Q+
Sbjct: 412 LKIMVHLGKHLNVVNLLGACPRKISKRELLVIVEYCRFGNLHNYLLRHRTDFINQIDPTT 471
Query: 721 EKNLGKINKGFLN---SVGTTGTHSDYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQ 777
K I + L SV + + SD ++ +T ++ G S + Q
Sbjct: 472 GKFDPSIGQDLLTRSVSVSSNNSLSDNSATESTNYQTSAMDSQGISMSPDGGIQSNNSSQ 531
Query: 778 EWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDN 837
W+ Y GDY + H +P+ + LL WAFQ+ARGMEYL+ RKVLHGDLAARN+LLA++N
Sbjct: 532 GWRFNYRGDY--KDHNLKPICTQDLLSWAFQVARGMEYLSQRKVLHGDLAARNILLAENN 589
Query: 838 VVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFS 897
VVKICDFGLA++MY + Y+KK LP+KW+AIE + DRIFSTQSD+WS+GIVLWE F+
Sbjct: 590 VVKICDFGLAKTMYKDNNYKKKGGGLLPIKWMAIESIRDRIFSTQSDIWSFGIVLWEFFT 649
Query: 898 LAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILG 957
LA+TPYP + + L +G RLE+P +A +YN+M +CW KP+ RPSFT+L + +G
Sbjct: 650 LAETPYPGMEAEKQYQKLIEGYRLEQPEYATSEIYNIMYQCWMAKPSLRPSFTQLVKNIG 709
Query: 958 NFLEDNERNRYVDLNAPYNEMNAELMTG--EDYLAMVCAPDYNNIVTPSPNYVNMAKS 1013
+ LE++ + Y+ LN PY +MN ++ G DYL M+ +PD+ + +P+ +Y N+ S
Sbjct: 710 DLLEESVKTHYISLNDPYMDMNTTMLEGGRNDYLTMLSSPDHTTLSSPTHDYSNLPSS 767
Score = 94.3 bits (224), Expect = 2e-17
Identities = 54/167 (32%), Positives = 88/167 (52%), Gaps = 12/167 (7%)
Query: 451 SIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIY 510
S+ L C G+P+P + WYK+DE+I D +T I +++ D+GIY
Sbjct: 248 SLILQCFVGGMPKPIVTWYKNDEVIKIG-------DQFTYTHNQQELHINYLRDIDSGIY 300
Query: 511 ECVALNNASELRRAYTLVLKAEKSYTPYXXXXXXXXXXXXGMVAYLFTWKLKKQR----E 566
C N ++ +++K ++ +V Y FT K+++++ E
Sbjct: 301 LCKGENRLGVIKAHGNIIVKGKEVPKELIILIVILSITVIILVVY-FTIKIRREKIMRKE 359
Query: 567 LTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTFGK 613
L +AGL++F+ G + NP L +D+QA+LLPYD+K+EFPREKL K
Sbjct: 360 LMEAGLMHFEEGAVECLNPELTVDDQAELLPYDKKWEFPREKLKLVK 406
Score = 61.3 bits (142), Expect = 1e-07
Identities = 48/175 (27%), Positives = 82/175 (46%), Gaps = 16/175 (9%)
Query: 262 IANYTLVAEN--KYLTKNYTVDLRVFTKPEAKLLNNRIIKRLENSEMNFACKVTGYPLPD 319
+ Y+L A N K+ N+T+D V KP L N + +C V +P P
Sbjct: 1 MGEYSLQATNQDKFDMLNFTLD--VLVKPVPMLKVEPYYS--PNQTVEISCDVATFPSPI 56
Query: 320 VTWIF-------SNDEEHELSSTKSEQESLYAKT-DYLKISVQASGVITCNAHNSKGEYF 371
+TW F S + + T +++ + + +K++++ SG +TC+A N G
Sbjct: 57 ITWSFIKYPYYPSYENATTIRLTNTKESGMNTRFHSIVKMTIEMSGHLTCSACNIIGCES 116
Query: 372 DSSTLLVYEINNGFGILQPLENWYSEKDSARKKCLASVYDY-DNVSWLGSDGNIL 425
+ T+LV + GFGI++ L++ E D C AS+Y+Y N W +G +
Sbjct: 117 QTETILVSDGRGGFGIIE-LKDPVVEGDDLELICAASIYNYTSNFEWKYENGTFI 170
>UniRef50_Q8AXB3 Cluster: Vascular endothelial growth factor receptor
2 precursor; n=10; Euteleostomi|Rep: Vascular endothelial
growth factor receptor 2 precursor - Danio rerio
(Zebrafish) (Brachydanio rerio)
Length = 1302
Score = 344 bits (846), Expect = 7e-93
Identities = 201/537 (37%), Positives = 303/537 (56%), Gaps = 40/537 (7%)
Query: 443 DEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENM 502
+++ ++ L C A GVP P I WYKD ++ G L D T IE +
Sbjct: 651 NQDVNSSSTLTLACLAYGVPAPFITWYKDKTPVTEGPGITLKDD--------GTLIIERV 702
Query: 503 QEKDNGIYECVALNNASELRRAYTLVLKAEKSYTPYXXXXXXXXXXXXGMVAYLFTWKLK 562
++ D GIYEC A N+ E + + + + E + + ++
Sbjct: 703 KKDDEGIYECRASNDGGEAKTSAVITVVGEDGKPNIEVIILVSTGAAATFLWIMLILFIR 762
Query: 563 KQRELTKAGLLNFKSGNKKSF-NPN-LGIDEQADLLPYDE-KFEFPREKLTFGKQLGAGA 619
K R+ + A L K+G +P + +DEQ D LPYD K+EFP+++L GK LG GA
Sbjct: 763 KLRKPSSADL---KTGYLSIIMDPEQMPLDEQCDRLPYDSNKWEFPQDRLRLGKTLGHGA 819
Query: 620 FGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGA 679
FG V +A A GI VAVKM+K A N +AL SELKI++H+G H+N+VNLLGA
Sbjct: 820 FGKVVEASAFGIDKISTCKTVAVKMLKVGATNNEWRALMSELKILIHIGHHLNVVNLLGA 879
Query: 680 CTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDNAEKNLGKINKGFLNSVGTTG 739
CTK L++IVE+CKYGN+ NY++ R F+ + + K +S G
Sbjct: 880 CTKRGGP--LMIIVEFCKYGNLSNYLRSKRGDFVVYKSQDG--------KAVRSSSGCD- 928
Query: 740 THSDYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTS 799
S K S+ +G+S SG + Y E + + + D +Y+ + LT
Sbjct: 929 ------LSELIKRRLESVASTGSSASSGFIEDKSYCDSEEEEEEQED-LYK----KVLTL 977
Query: 800 GHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKK 859
L+ ++FQ+A+GME+LA+RK +H DLAARN+LL+++NVVKICDFGLAR +Y + +Y +K
Sbjct: 978 EDLICYSFQVAKGMEFLASRKCIHRDLAARNILLSENNVVKICDFGLARDVYKDPDYVRK 1037
Query: 860 ENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS-PTDLLRWLSDG 918
++ LP+KW+A E + D+I++TQSDVWS+G+++WE+FSL +PYP + + L +G
Sbjct: 1038 GDARLPLKWMAPEAIFDKIYTTQSDVWSFGVLMWEIFSLGASPYPGLHIDEEFCCRLKEG 1097
Query: 919 NRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE---DNERNRYVDLN 972
R++ P ++ +Y ML CWH +P+ RP+FTEL E LG+ L+ E Y+ +N
Sbjct: 1098 TRMKAPEYSSSEIYQTMLDCWHGEPSQRPTFTELVERLGDLLQASVQQEGKHYIPIN 1154
Score = 59.7 bits (138), Expect = 5e-07
Identities = 68/325 (20%), Positives = 127/325 (39%), Gaps = 27/325 (8%)
Query: 14 VIECRPTTPDVNVTLSSEI---PDYYYPSFRYSPKIGF-VPENSMPSDDQIISFVLCEFV 69
V+ CR T P+ NV L +++ D ++ PK GF VP P D + + C
Sbjct: 147 VVPCRTTYPNQNVILETQMNPMADDVKRGVQWDPKKGFTVPLK--PYDSYHL--ITC-LT 201
Query: 70 RGETRIEKYIYVSKHIKKPPKP-KVAGGHKQFLEGETFTIHCRVPN--DGLINFKWKYPP 126
R + +Y+ K + K + + L G+T ++C +G I+F+W++
Sbjct: 202 RVDNAEFSSVYLLKRLTMEIKNLAIEPERPRVLVGDTLILNCSAETTYNGRIHFEWEFHK 261
Query: 127 EVTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEKDEFRKIFL 186
E N + S + ++ + + + N T + G YTC + + + + I
Sbjct: 262 ERINRTHHFSTTPVQLAQI-MVMSKALIVPNVTMEDKGTYTCTGSIEFKKLQMSTKVIVY 320
Query: 187 EKPFLSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDKYLPSNDLKYNVTTLA 246
E PFL++ + + + + A P +R + K+ + N Y
Sbjct: 321 EHPFLNVTHNKRKFTSTVEGRRVQFEPRVNAVPAPDRVLWYKDGVAISENSTCYETAGY- 379
Query: 247 NGDPKLRINDLKLTDIANYTLVAENKY--LTKNYTVDLRVFTKPEAKLLNNRIIKR---- 300
L I ++ D +T+ N+ L +N + L V KP K+ +
Sbjct: 380 ----NLTIKQVRQKDAGIFTIALSNQERGLYRNISYKLEVRVKP--KIFEEDVAPAGPQT 433
Query: 301 -LENSEMNFACKVTGYPLPDVTWIF 324
+ C G P+P++TW +
Sbjct: 434 FRYDQRHKLTCTAFGIPMPNITWFW 458
Score = 35.9 bits (79), Expect = 6.4
Identities = 24/80 (30%), Positives = 36/80 (45%), Gaps = 10/80 (12%)
Query: 439 DSNKDEEAMEGRSIQLHCEAEGVPRPT-IYWYKDDELISNNSGYKLFVDIVNHTIVNSTF 497
+ K +EGR +Q VP P + WYKD IS NS +
Sbjct: 330 NKRKFTSTVEGRRVQFEPRVNAVPAPDRVLWYKDGVAISENS--------TCYETAGYNL 381
Query: 498 EIENMQEKDNGIYECVALNN 517
I+ +++KD GI+ +AL+N
Sbjct: 382 TIKQVRQKDAGIF-TIALSN 400
>UniRef50_P17948 Cluster: Vascular endothelial growth factor receptor
1 precursor; n=48; cellular organisms|Rep: Vascular
endothelial growth factor receptor 1 precursor - Homo
sapiens (Human)
Length = 1338
Score = 343 bits (844), Expect = 1e-92
Identities = 211/576 (36%), Positives = 307/576 (53%), Gaps = 48/576 (8%)
Query: 451 SIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIY 510
S L C A GVP P I W+K++ I G L +ST IE + E+D G+Y
Sbjct: 677 STTLDCHANGVPEPQITWFKNNHKIQQEPGIILGPG-------SSTLFIERVTEEDEGVY 729
Query: 511 ECVALNNASELRRAYTLVLK--AEKSYTPYXXXXXX-XXXXXXGMVAYLFTWKLKKQREL 567
C A N + + L ++ ++KS ++ LF K+K+
Sbjct: 730 HCKATNQKGSVESSAYLTVQGTSDKSNLELITLTCTCVAATLFWLLLTLFIRKMKRSSSE 789
Query: 568 TKAGLLNFKSGNKKSFNPN-LGIDEQADLLPYD-EKFEFPREKLTFGKQLGAGAFGVVYK 625
K L+ +P+ + +DEQ + LPYD K+EF RE+L GK LG GAFG V +
Sbjct: 790 IKTDYLSI------IMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQ 843
Query: 626 AEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIA 685
A A GI + VAVKM+K A KAL +ELKI+ H+G H+N+VNLLGACTK
Sbjct: 844 ASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGG 903
Query: 686 KRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDNAEKNLGKINKGFLNSVGTTGTHSDYF 745
L+VIVEYCKYGN+ NY++ R++F +NK + +
Sbjct: 904 P--LMVIVEYCKYGNLSNYLKSKRDLFF-------------LNKDAALHMEPKKEKMEPG 948
Query: 746 SSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGW 805
K S+ S + SG + + E + +G Y P+T L+ +
Sbjct: 949 LEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFY------KEPITMEDLISY 1002
Query: 806 AFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLP 865
+FQ+ARGME+L++RK +H DLAARN+LL+++NVVKICDFGLAR +Y N +Y +K ++ LP
Sbjct: 1003 SFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLP 1062
Query: 866 VKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS-PTDLLRWLSDGNRLEKP 924
+KW+A E + D+I+ST+SDVWSYG++LWE+FSL +PYP + D L +G R+ P
Sbjct: 1063 LKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAP 1122
Query: 925 PFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN---ERNRYVDLNAPYNEMNAE 981
++ +Y +ML CWH+ P RP F EL E LG+ L+ N + Y+ +NA +
Sbjct: 1123 EYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLLQANVQQDGKDYIPINAILTGNSGF 1182
Query: 982 LMT----GEDYL-AMVCAPDYNNIVTPSPNYVNMAK 1012
+ ED+ + AP +N+ + YVN K
Sbjct: 1183 TYSTPAFSEDFFKESISAPKFNSGSSDDVRYVNAFK 1218
Score = 69.7 bits (163), Expect = 4e-10
Identities = 103/460 (22%), Positives = 181/460 (39%), Gaps = 57/460 (12%)
Query: 3 EIVVPRDCSKIVIECRPTTPDVNVTLSSEIPDYYYPSFR---YSPKIGFVPENSMPSDDQ 59
EI+ + ++VI CR T+P++ VTL D P + + + GF+ N+ +
Sbjct: 144 EIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKE-- 201
Query: 60 IISFVLCE-FVRGETRIEKYIYVSKHIKKPPKPKVAGGHK-QFLEGETFTIHC--RVPND 115
I + CE V G Y+ + +++ + L G T ++C P +
Sbjct: 202 -IGLLTCEATVNGHLYKTNYL-THRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLN 259
Query: 116 GLINFKWKYPPEVTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCG 175
+ W YP E N V ++ + +I Y +TI K G+YTC + +
Sbjct: 260 TRVQMTWSYPDE-KNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPS 318
Query: 176 EEKDEFRKIFLEKPFLSLRDLAKGKLMGNANK-SINIVIEIEAYPPVERTHFLKNDKYLP 234
+ +K F++++ + L A K S + ++++A+P E +LK+ LP
Sbjct: 319 FKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPE-VVWLKDG--LP 375
Query: 235 SNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKY--LTKNYTVDLRVFTKPE--A 290
+ + T L I D+ D NYT++ K + KN T L V KP+
Sbjct: 376 ATEKSARYLTRGY---SLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYE 432
Query: 291 KLLNNRIIKRLE--NSEMNFACKVTGYPLPDVTWIF---------------SNDEE---- 329
K +++ L S C G P P + W + SN+EE
Sbjct: 433 KAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFIL 492
Query: 330 -------HELSSTKSEQESLYAKTDYLKISVQA----SGVITCNAHNSKGEYFDSSTLLV 378
+ + S + K V A SG+ C A N G + + +
Sbjct: 493 DADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYI 552
Query: 379 YEINNGFGILQPLENWYSEKDSARKKCLASVYDYDNVSWL 418
++ NGF + LE +E + + C + + Y +V+W+
Sbjct: 553 TDVPNGFHV--NLEKMPTEGEDLKLSCTVNKFLYRDVTWI 590
Score = 41.9 bits (94), Expect = 0.098
Identities = 22/82 (26%), Positives = 34/82 (41%), Gaps = 4/82 (4%)
Query: 87 KPPKPKVAGGHKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVEVSVVKTEATTTG 146
K P+ + G G+T + CR G KW P V+ +S +S+ K+ G
Sbjct: 30 KDPELSLKGTQHIMQAGQTLHLQCR----GEAAHKWSLPEMVSKESERLSITKSACGRNG 85
Query: 147 SIVYQNITIRNATKKHNGVYTC 168
+T+ A H G Y+C
Sbjct: 86 KQFCSTLTLNTAQANHTGFYSC 107
Score = 37.1 bits (82), Expect = 2.8
Identities = 40/156 (25%), Positives = 64/156 (41%), Gaps = 8/156 (5%)
Query: 81 VSKHIKKPPKPKVAGGHKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVEVSVVKT 140
+S +I P K EGE + C V + W V N ++ S+ K
Sbjct: 548 ISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQ 607
Query: 141 E-ATTTGSIVYQNITIRNATKKHNGVYTCLLTNT-CGEEKDEFRKIFL---EKPFLSLRD 195
+ A T + N+TI N + + +G Y C N GEE + ++I + E P+L LR+
Sbjct: 608 KMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYL-LRN 666
Query: 196 LAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDK 231
L+ + + S + P + T F N K
Sbjct: 667 LSDHTVA--ISSSTTLDCHANGVPEPQITWFKNNHK 700
Score = 35.5 bits (78), Expect = 8.5
Identities = 30/122 (24%), Positives = 52/122 (42%), Gaps = 11/122 (9%)
Query: 252 LRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRLENSEMNFACK 311
L + D +++ I Y +A NK T + + P +N + E ++ +C
Sbjct: 522 LVVADSRISGI--YICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPT-EGEDLKLSCT 578
Query: 312 VTGYPLPDVTWIF----SNDEEH-ELSSTK---SEQESLYAKTDYLKISVQASGVITCNA 363
V + DVTWI +N H +S K +++ S+ + +S+Q SG C A
Sbjct: 579 VNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRA 638
Query: 364 HN 365
N
Sbjct: 639 RN 640
>UniRef50_P35968 Cluster: Vascular endothelial growth factor receptor
2 precursor; n=49; Bilateria|Rep: Vascular endothelial
growth factor receptor 2 precursor - Homo sapiens (Human)
Length = 1356
Score = 336 bits (826), Expect = 2e-90
Identities = 280/980 (28%), Positives = 448/980 (45%), Gaps = 81/980 (8%)
Query: 12 KIVIECRPTTPDVNVTLSSEIPDYYYPSFRYSPKIGFVPENSMPSDDQIISFVLCEFVRG 71
K+V+ C T ++NV + ++ YPS ++ K + S ++ F+ + G
Sbjct: 241 KLVLNCTART-ELNVGIDF---NWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDG 296
Query: 72 ETRIEKYIYV------------SKHIKKPPKPKVA-GGHKQFLEGETFTIHCRVPNDGLI 118
TR ++ +Y S ++ KP VA G + L T R+P
Sbjct: 297 VTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIP----A 352
Query: 119 NFKWKYPPEVTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEK 178
+ PPE+ + + G + +TI +++ G YT +LTN +EK
Sbjct: 353 KYLGYPPPEIKWYKNGIPLESNHTIKAGHV----LTIMEVSERDTGNYTVILTNPISKEK 408
Query: 179 DEF--RKIFLEKPFLSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDKYLPSN 236
+ P + + L + + + A PP H+ + +N
Sbjct: 409 QSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECAN 468
Query: 237 DLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLT---KNYTVDLRVFTKPEAKLL 293
+ V+ + N P ++ N V +N++ KN TV V L
Sbjct: 469 EPSQAVS-VTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSAL 527
Query: 294 NN-RIIKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYLKIS 352
+ ++ E + VT P + E+ +S + S + + K+
Sbjct: 528 YKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLG 587
Query: 353 VQASGVITCNAHNSKGEYFDSSTLL---VYEINNGFGILQPLENWYSEKDSARKKCLASV 409
Q + + D+ L ++ + ++ L+N S +D CLA
Sbjct: 588 PQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKN-ASLQDQGDYVCLAQD 646
Query: 410 YDYDNVSWLGSDGNILDDIELLAPIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWY 469
+ +L E +AP I N+ G SI++ C A G P P I W+
Sbjct: 647 RKTKKRHCVVRQLTVL---ERVAPTITGNLENQTTSI--GESIEVSCTASGNPPPQIMWF 701
Query: 470 KDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIYECVALNNASELRRAYTLVL 529
KD+E + +SG L N I ++++D G+Y C A + + ++
Sbjct: 702 KDNETLVEDSGIVLKDG-------NRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFII 754
Query: 530 KAEKSYTPYXXXXXXXXXXXXGMVAYLFTWKLKK--QRELTKAGLLNFKSGNKKS-FNPN 586
+ + T V +F W L R + +A K+G +P+
Sbjct: 755 EGAQEKTNLEIIILVGTA-----VIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPD 809
Query: 587 -LGIDEQADLLPYD-EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKM 644
L +DE + LPYD K+EFPR++L GK LG GAFG V +A+A GI VAVKM
Sbjct: 810 ELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKM 869
Query: 645 VKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNY 704
+K A + +AL SELKI++H+G H+N+VNLLGACTK L+VIVE+CK+GN+ Y
Sbjct: 870 LKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTK--PGGPLMVIVEFCKFGNLSTY 927
Query: 705 MQKHREVFIDQLTDNAEKNLGKINKGFLNSVGTTGTHSDYFSSGNTKDTDHSLLYSGNSK 764
++ R F+ T A GK DY + D L +S+
Sbjct: 928 LRSKRNEFVPYKTKGARFRQGK----------------DYVGAIPV-DLKRRLDSITSSQ 970
Query: 765 RSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHG 824
S S G+++++ + E + E LT HL+ ++FQ+A+GME+LA+RK +H
Sbjct: 971 SSA---SSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHR 1027
Query: 825 DLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSD 884
DLAARN+LL++ NVVKICDFGLAR +Y + +Y +K ++ LP+KW+A E + DR+++ QSD
Sbjct: 1028 DLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSD 1087
Query: 885 VWSYGIVLWEMFSLAKTPYPNIS-PTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKP 943
VWS+G++LWE+FSL +PYP + + R L +G R+ P + +Y ML CWH +P
Sbjct: 1088 VWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEP 1147
Query: 944 TARPSFTELQEILGNFLEDN 963
+ RP+F+EL E LGN L+ N
Sbjct: 1148 SQRPTFSELVEHLGNLLQAN 1167
Score = 57.6 bits (133), Expect = 2e-06
Identities = 76/331 (22%), Positives = 132/331 (39%), Gaps = 25/331 (7%)
Query: 13 IVIECRPTTPDVNVTLSSEIPDY-YYPS---FRYSPKIGFVPENSMPSDDQIISFVLCEF 68
+VI C + ++NV+L + P+ + P + K GF + M S V CE
Sbjct: 146 VVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMIS---YAGMVFCEA 202
Query: 69 VRGETRIEKYIYVSKHIKKPPKPKVAG-GHKQFLE-GETFTIHC--RVPNDGLINFKWKY 124
+ + +Y+ + V H L GE ++C R + I+F W+Y
Sbjct: 203 KINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEY 262
Query: 125 PPEVTNDSVEVSV-VKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEKDEFRK 183
P V+ +KT++ + +TI T+ G+YTC ++ +K+
Sbjct: 263 PSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFV 322
Query: 184 IFLEKPFLSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDKYLPSNDLKYNVT 243
EKPF++ + + + + I + YPP E + KN L SN
Sbjct: 323 RVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPE-IKWYKNGIPLESNH------ 375
Query: 244 TLANGDPKLRINDLKLTDIANYTLVAENKYL--TKNYTVDLRVFTKPE--AKLLNNRIIK 299
T+ G L I ++ D NYT++ N +++ V L V+ P+ K L + +
Sbjct: 376 TIKAGH-VLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDS 434
Query: 300 RLENSEMNFACKVTGYPLP-DVTWIFSNDEE 329
+ C V P P + W + +EE
Sbjct: 435 YQYGTTQTLTCTVYAIPPPHHIHWYWQLEEE 465
>UniRef50_Q4JDD5 Cluster: Tyrosine-protein kinase receptor; n=5; Danio
rerio|Rep: Tyrosine-protein kinase receptor - Danio rerio
(Zebrafish) (Brachydanio rerio)
Length = 1272
Score = 331 bits (813), Expect = 7e-89
Identities = 208/541 (38%), Positives = 294/541 (54%), Gaps = 53/541 (9%)
Query: 443 DEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENM 502
D SI LHC A GVP+P I WYK+ + SG LF + T I+ +
Sbjct: 658 DHTVNVSNSITLHCPARGVPQPHITWYKNQRKLQQVSGIMLFPE-------EGTLHIDRI 710
Query: 503 QEKDNGIYECVALNNASELRR-AYTLVLKAEKSYTPYXXXXXXXXXXXXGMVAYLFTWKL 561
+D G Y C A N + AY V + +S + +VA LF W L
Sbjct: 711 TVEDQGFYTCQATNQRGSMESSAYIWVQNSSESLS-----LEIPTLACTCVVATLF-WLL 764
Query: 562 KKQ--RELTKAGLLNFKSGNKKSF-NPNLG-IDEQADLLPYDE-KFEFPREKLTFGKQLG 616
R+L +N K+ +P + E D L YD K+EFPR++L K LG
Sbjct: 765 LTLLIRKLKHPNSVNGKAEYLPIILHPGEEPLVEHCDRLQYDPAKWEFPRDRLKLEKPLG 824
Query: 617 AGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNL 676
GAFG V +A A G N+ T VAVKM+K A KAL +ELKI+ H+G H+N+VNL
Sbjct: 825 RGAFGRVMQASAVGTGNSASCTTVAVKMLKDGATPSEHKALMTELKILNHIGHHINVVNL 884
Query: 677 LGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDNAEKNLGKINKGFLNSVG 736
LGACTK + L+VIVEYC++GN+ Y++ REVF+ L ++NK
Sbjct: 885 LGACTK--SGGPLMVIVEYCQFGNLSAYLKSKREVFL----------LNRVNKE------ 926
Query: 737 TTGTHSDYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQEWQTKYEGDYIYECHQPRP 796
G K+ L S +S++S S G+ ++ + E Y P
Sbjct: 927 ---------EEGVMKEGCKGRLTSVSSRQSN--ASSGFSEERGEISEEDSYCLS-ELSDP 974
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
L L+ ++FQ+ARGME+LA+RK +H DLAARN+LL+++NVVKICDFGLAR +Y + +Y
Sbjct: 975 LLLEDLISYSFQVARGMEFLASRKCIHRDLAARNILLSNNNVVKICDFGLARDLYKDPDY 1034
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS-PTDLLRWL 915
+ ++ LP+KW+A E + D++F+TQSDVWSYG++LWE+FSL +PYP ++ + R L
Sbjct: 1035 VRNGDARLPLKWMAPESIFDKVFTTQSDVWSYGVLLWEIFSLGASPYPGLNMDEEFCRRL 1094
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE---DNERNRYVDLN 972
G R+ P ++ +Y++M CW P RPSFT L EILG+ L+ + Y+ LN
Sbjct: 1095 KHGTRMCSPQYSTPEIYSIMCACWENNPEDRPSFTTLVEILGDLLQTCVQQDGKDYIPLN 1154
Query: 973 A 973
A
Sbjct: 1155 A 1155
Score = 64.1 bits (149), Expect = 2e-08
Identities = 74/337 (21%), Positives = 143/337 (42%), Gaps = 29/337 (8%)
Query: 3 EIVVPRDCSKIVIECRPTTPDVNVTLSSEIPDYYYPSFRYSPKIGFVPENSMPSDD-QII 61
++V ++ +V CR T P+ V+L +P R +P + NS +
Sbjct: 137 DVVYMKEGEPLVFPCRVTNPEAKVSLVK------FPLHRITPDHRNIIWNSRQGFIIRSP 190
Query: 62 SFVLCEFVRGETRIEKYIYVSKHIKKPPKPKV------AGGHKQFLEGETFTIHCRVPND 115
+F ET ++ Y +K + P K+ + G L+GE ++C V +
Sbjct: 191 TFFYIGLFSCETIVDGVKYTNKFLTHRPVNKILDVYLNSTGLVHTLQGEMLALNCTVTAE 250
Query: 116 --GLINFKWKYPPEVTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNT 173
++ W YP + N S +S + + + + Y +TI + +K G+Y C +T+
Sbjct: 251 WNSRVSISWTYPQKA-NGSAIISK-RISRSRSNMLFYSVLTIPSLSKADKGLYKCQVTSG 308
Query: 174 CGEEKDEFRKIFLEKPFLSLRDLAKGKLMGNA-NKSINIVIEIEAYPPVERTHFLKNDKY 232
+ + I ++PF+ L+ + A KS + +++A+P E +LK+
Sbjct: 309 PSKRETNTTVIVYDQPFIRLKHRNGPVVQAFAGQKSFRLTPKLKAFPAPE-IIWLKDGMV 367
Query: 233 LPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVA--ENKYLTKNYTVDLRVFTKPE- 289
+Y+V + L I D+ D YT++ + L +N T+ L V KP+
Sbjct: 368 AAERCSRYHVDGFS-----LVIRDVAEEDAGIYTILTGIQQYGLFQNLTITLVVNVKPQI 422
Query: 290 -AKLLNNRIIKRLE-NSEMNFACKVTGYPLPDVTWIF 324
K ++++ ++ S C G P P + W++
Sbjct: 423 GEKSVSSQQPGTVQRGSRQALHCTSHGVPPPQIQWLW 459
>UniRef50_Q4SJQ3 Cluster: Tyrosine-protein kinase receptor; n=1;
Tetraodon nigroviridis|Rep: Tyrosine-protein kinase
receptor - Tetraodon nigroviridis (Green puffer)
Length = 1387
Score = 325 bits (798), Expect = 5e-87
Identities = 194/533 (36%), Positives = 295/533 (55%), Gaps = 45/533 (8%)
Query: 451 SIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIY 510
S+++ C+ EG P P + W+KD++ + SG +L N T I+ ++E+D G+Y
Sbjct: 706 SLRMECDVEGRPLPRLLWFKDNQPLHQMSGIQLQDS-------NRTLSIQRVREEDAGLY 758
Query: 511 ECVALNNASELRRAYTLVLKAEKSYTPYXXXXXXXXXXXXGMVAYLFTWKLKKQR--ELT 568
C A N + + + + G++A F W L +
Sbjct: 759 TCTACNRRGCIHSSAAVRVIGSSD----KANVEIVILIGTGVIAVFF-WALLILIFCNVK 813
Query: 569 KAGLLNFKSGNKKSF-NPN-LGIDEQADLLPYDE-KFEFPREKLTFGKQLGAGAFGVVYK 625
+ + K+G +P + ++EQ + LPYD ++E R++L GK LG GAFG V +
Sbjct: 814 RVNPADIKTGYLSIIMDPGQVPLEEQCECLPYDSSQWEVSRDRLRLGKVLGHGAFGKVME 873
Query: 626 AEARGIINAEVTTP-VAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHI 684
A RGI + VAVKM+K A KAL SELKI++H+G H+N+VNLLGACTK
Sbjct: 874 ASIRGIDKGGSSLDTVAVKMLKDGATASEHKALMSELKILIHIGNHLNVVNLLGACTK-- 931
Query: 685 AKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDNAEKNLGKINKGFLNSVGTTGTHSDY 744
A L+V+VEYCKYGN+ NY++ RE F+ D + K ++ + + G +
Sbjct: 932 ANGPLMVVVEYCKYGNLSNYLRAKREFFLPY-RDRSPKTQSQVRR--MIEAGQAARRAPR 988
Query: 745 FSSG-NTKDTDHSLLYSGNSKRSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLL 803
S ++ DH N+ V + ++ W+T PLT L+
Sbjct: 989 PPSPPSSTHIDHESPLC-NAPTQSPSVEK--VEDLWKT--------------PLTIEDLI 1031
Query: 804 GWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSP 863
++FQ+ARGME+LA+RK +H DLAARN+LL++ N+VKICDFGLAR +Y + +Y +K N+
Sbjct: 1032 CYSFQVARGMEFLASRKCIHRDLAARNILLSESNIVKICDFGLARDIYKDPDYVRKGNAR 1091
Query: 864 LPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS-PTDLLRWLSDGNRLE 922
LP+KW+A E + D+++++QSDVWS+G++LWE+FSL +PYP + + L DG R+
Sbjct: 1092 LPLKWMAPESIFDKVYTSQSDVWSFGVLLWEIFSLGASPYPGVQIDEEFCNRLRDGFRMR 1151
Query: 923 KPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN---ERNRYVDLN 972
P A +Y +ML CW +P RP+F L +ILG+ L+DN + YV LN
Sbjct: 1152 APDTASPEIYGIMLACWQAEPKDRPTFPSLVQILGDLLQDNSLPDGKDYVPLN 1204
Score = 112 bits (270), Expect = 5e-23
Identities = 114/443 (25%), Positives = 182/443 (41%), Gaps = 23/443 (5%)
Query: 1 MREIVVPRDCSKIVIECRPTTPDVNVTLSSEIPDYYYPSFRYSPKIGF-VPENSMPSDDQ 59
+ I++ R S + + C T PD+NVTL S + K G+ +P + S
Sbjct: 178 LETILMTRSSSHLTVPCLVTVPDLNVTLQSHSLSLDRREITWDNKQGWSIPRRFIDSSPL 237
Query: 60 IISFVLCEFVRGETRIEKYIYVSKHIKKPPKPKVA---GGHKQFLEGETFTIHCR--VPN 114
+++F C G + +Y+ HI KV + + G+T T++C V
Sbjct: 238 LVTFS-CVATLGGKEFQSAVYLI-HITGSEVYKVKLFPVDPVELIAGDTLTLNCTALVEF 295
Query: 115 DGLINFKWKYPPEVTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTC 174
D + +W YP ++TN V+V + EA + V +TI T G Y+C +T+T
Sbjct: 296 DTGLEIQWSYPGKLTNRQVDVKPFR-EALFHATEVASILTIHKVTANDTGSYSCNVTSTD 354
Query: 175 GEEKDEFRKIFLEKPFLSLRDLAKGKL--MGNANKSINIVIEIEAYPPVERTHFLKNDKY 232
+ + + EKPF+SL + G + + KS + + + A+P E F + K
Sbjct: 355 TTQVQQTQVKVYEKPFISL-NYRNGPVEEVTAGQKSSKLQVNVSAFPTPETQWFKEGKKI 413
Query: 233 LPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENK--YLTKNYTVDLRVFTKPE- 289
+ K + + D L I D+ D YT+V N L + + L V P+
Sbjct: 414 NHRPEFKMKKMKI-HLDHALEIRDVCEEDSGLYTVVLRNSAAQLERRLNITLVVNVPPQI 472
Query: 290 -AKLLNNRIIKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYAKTDY 348
K + S C G P P V+W + +ST+S+ L A
Sbjct: 473 HEKEVAAPSSPYPSGSSQTLTCSAYGLPAPVVSWQWRAWGPCVQNSTQSKPCLLSASQMV 532
Query: 349 LKISVQASGV---ITCNAHNSKGEYFDSSTLLVYEINNGFGI-LQPLENWYSEKDSARKK 404
++ ++ + V C+A N GE V I GF + LQP EN E+D
Sbjct: 533 SRLHIRNASVSVMYKCSAVNKAGEDERLIYFYVTTIPEGFSVDLQPSEN--QEQDKVSLC 590
Query: 405 CLASVYDYDNVSWLGSDGNILDD 427
C A Y Y ++ W D L D
Sbjct: 591 CRADNYTYQSLRWYRLDPRALPD 613
Score = 41.5 bits (93), Expect = 0.13
Identities = 23/87 (26%), Positives = 45/87 (51%), Gaps = 4/87 (4%)
Query: 444 EEAMEG-RSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENM 502
EE G +S +L P P W+K+ + I++ +K+ ++ ++ EI ++
Sbjct: 381 EEVTAGQKSSKLQVNVSAFPTPETQWFKEGKKINHRPEFKMKKMKIH---LDHALEIRDV 437
Query: 503 QEKDNGIYECVALNNASELRRAYTLVL 529
E+D+G+Y V N+A++L R + L
Sbjct: 438 CEEDSGLYTVVLRNSAAQLERRLNITL 464
Score = 37.1 bits (82), Expect = 2.8
Identities = 28/125 (22%), Positives = 51/125 (40%), Gaps = 5/125 (4%)
Query: 257 LKLTDIANYTLVAENKYLTKNYTVDLRVFTKP-EAKLLNNRIIKRLEN--SEMNFACKVT 313
++L D +Y A+ + K + V K EA + + N + C V
Sbjct: 655 VQLRDEGHYVCEAQRRRSGKKQCLFRYVSVKALEAPRYKRSLTNQTVNVTGSLRMECDVE 714
Query: 314 GYPLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYLKISVQASGVITCNAHNSKGEYFDS 373
G PLP + W N H++S + + + ++ + +G+ TC A N +G S
Sbjct: 715 GRPLPRLLWFKDNQPLHQMSGIQLQDSN--RTLSIQRVREEDAGLYTCTACNRRGCIHSS 772
Query: 374 STLLV 378
+ + V
Sbjct: 773 AAVRV 777
>UniRef50_Q4RP85 Cluster: Tyrosine-protein kinase receptor; n=3;
Tetraodontidae|Rep: Tyrosine-protein kinase receptor -
Tetraodon nigroviridis (Green puffer)
Length = 468
Score = 303 bits (744), Expect = 2e-80
Identities = 183/483 (37%), Positives = 275/483 (56%), Gaps = 45/483 (9%)
Query: 451 SIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIY 510
+++L C A GVPRP I WYK+ L+ + G L D V I+ +++ D G+Y
Sbjct: 22 TLKLECYARGVPRPEITWYKNGVLLKQSPGITLSEDGV--------LIIDRVKKDDEGLY 73
Query: 511 ECVALNNASELRRAYTLVLKAEK---SYTPYXXXXXXXXXXXXGMVAYLFTWKLKKQREL 567
CVA N + ++ + ++ + ++ LF KL+KQ
Sbjct: 74 SCVAKNVEGSANTSASITVHGDEGRPNIEVIILVCTGAAATFLWLMLILFIRKLRKQPA- 132
Query: 568 TKAGLLNFKSGNKKSFNPN-LGIDEQADLLPYDE-KFEFPREKLTFGKQLGAGAFGVVYK 625
++K G +P+ ++EQ DLL YD ++EFPR++L GK LG GAFG V +
Sbjct: 133 ------HYKMGPSIIIDPDECPLEEQNDLLQYDSSRWEFPRDRLQLGKTLGHGAFGKVVE 186
Query: 626 AEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIA 685
A A GI VAVKM+K A + KAL SELKI++H+G H+N+VNLLGACTK
Sbjct: 187 ASAFGIDKMSTCKTVAVKMLKGGATSNERKALMSELKILIHIGHHLNVVNLLGACTK--P 244
Query: 686 KRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDNAEKNLGKINKGFLNSVGTTGTHSDYF 745
L++IVE+CKYGN+ NY++ R+ FI + K KG + G
Sbjct: 245 GGPLMMIVEFCKYGNLSNYLRSRRDDFI----------VYKDGKGVSSMSGIE------- 287
Query: 746 SSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGW 805
S K S+ +G+S SG + Y E + + E + +Y+ R LT L+ +
Sbjct: 288 LSELMKRRLESVASTGSSASSGFIEDKSYCDSE-EEEQESEDLYK----RVLTLEDLICY 342
Query: 806 AFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLP 865
+FQ+A+GME+LA+RK +H DLAARN+LL+++NVVKICDFGLAR +Y + +Y +K ++ LP
Sbjct: 343 SFQVAKGMEFLASRKCIHRDLAARNILLSENNVVKICDFGLARDIYKDPDYVRKGDARLP 402
Query: 866 VKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS-PTDLLRWLSDGNRLEKP 924
+KW+A E + D+I++TQSDVWS+G+++WE+FSL +PYP + + L DG R+ P
Sbjct: 403 LKWMAPEAIFDKIYTTQSDVWSFGVLMWEIFSLGASPYPGVQIDEEFCCKLKDGTRMRAP 462
Query: 925 PFA 927
++
Sbjct: 463 EYS 465
>UniRef50_Q4H2M8 Cluster: Tyrosine-protein kinase receptor; n=1;
Ciona intestinalis|Rep: Tyrosine-protein kinase receptor
- Ciona intestinalis (Transparent sea squirt)
Length = 817
Score = 301 bits (739), Expect = 7e-80
Identities = 187/547 (34%), Positives = 293/547 (53%), Gaps = 51/547 (9%)
Query: 449 GRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNG 508
G + L C A G P PT+ WY +D ++ + KL S I +++ D G
Sbjct: 175 GDDVLLSCNATGQPAPTVTWYHEDVIVQES---KL-----------SELMIRRVKQVDGG 220
Query: 509 IYECVALNNASELRRAYTLVLKAEKSYTPYXXXXXXXXXXXXGMVAYLFTWKLKKQ--RE 566
+Y CVA N + ++ +L ++ + + L +L+K+ E
Sbjct: 221 VYICVAENQYGKDNKSVSLNIQGDHQMQIMFAASGVSCLVLI-LACGLIAMRLRKKVKHE 279
Query: 567 LTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYD-EKFEFPREKLTFGKQLGAGAFGVVYK 625
+ LLN K ++ ++EQA YD +K+EFPR++L FGK LG GAFG V +
Sbjct: 280 KCMSALLNIK---------DMPLEEQAQCSEYDSKKWEFPRDRLRFGKTLGRGAFGKVIQ 330
Query: 626 AEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIA 685
A A + + VAVKM+K + + +AL +EL+I++HLG H+NIVNLLGACT
Sbjct: 331 ATAFDLEKSSSCKTVAVKMLKVGSRSNEYRALMTELRILIHLGPHLNIVNLLGACTTK-- 388
Query: 686 KRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDNAEKNLGKINK---------GFLNSVG 736
+ L+VIVEYC++GN+ NY++ R + ++ K K + G +
Sbjct: 389 EGPLMVIVEYCRHGNLSNYLRGLRHCYTGGRNEDTSKQEIKKQRLMSDDSADDGAFSGTD 448
Query: 737 TT----------GTHSDYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQEWQTKYEGD 786
T G+ + Y S + + + S SG + S +++ + +GD
Sbjct: 449 ETDRSSWITDKRGSRASYLSGTGSLTSHEGDIRSHTRLSSGCEDSRMNLEKHHEANDDGD 508
Query: 787 YIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGL 846
+ Q LT LL ++ Q+ARGME+LA++K +H DLAARNVLL+D VVKICDFGL
Sbjct: 509 EKGK-EQKDQLTLTDLLSYSLQVARGMEFLASKKCIHRDLAARNVLLSDYQVVKICDFGL 567
Query: 847 ARSMYNNEEYQKK-ENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN 905
AR +Y + +Y + ++ LP+KW+A E + D+++S +SDVWS+G++LWE+F+L +PYP
Sbjct: 568 ARDIYKDPDYVRSGGDARLPIKWMAPESIFDKVYSNKSDVWSFGVLLWEIFTLGGSPYPG 627
Query: 906 IS-PTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
+ D L G R+ KP A D +Y+ ML CW P RP+FT+L E + + L++
Sbjct: 628 LQMDEDFCNKLRRGVRMGKPEHATDSVYSAMLGCWDNNPEDRPTFTKLCEEISDVLQEEA 687
Query: 965 RNRYVDL 971
+ Y+D+
Sbjct: 688 GHEYLDV 694
Score = 39.9 bits (89), Expect = 0.40
Identities = 58/244 (23%), Positives = 96/244 (39%), Gaps = 25/244 (10%)
Query: 138 VKTEATTTGSIVY-QNITIRNATKKHNGVYTCLLTNTCGEEKDEFRKIFLEKPFLSLRDL 196
V E+T + +I + + I++A+ +G Y+C L + E K++ EK F+++ L
Sbjct: 2 VAGESTDSNTIKWCSTLLIKHASLLDSGKYSCHLLSNVRTESSVNIKVY-EKSFINV--L 58
Query: 197 AKGKLMGNANKSIN-----IVIEIEAYPP-----VERTHFLKNDKYLPSNDLKYNVTTLA 246
+ N + I I + A+P T + + L +
Sbjct: 59 STPTTSSNVIEVIKGEMAAIKYSVHAFPTPTFNWFNGTQSISRSSISTTTQLSNDSRVST 118
Query: 247 NGDPKLRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRLE-NSE 305
NG L I ++K +D Y L K L N T L V A++ N + + +
Sbjct: 119 NGSTLL-IKNVKFSDSGWYMLSVSVKNLMINETFLLIVQDPLPARIENLDLFINADIGDD 177
Query: 306 MNFACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYLKISVQASGVITCNAHN 365
+ +C TG P P VTW HE QES ++ ++ GV C A N
Sbjct: 178 VLLSCNATGQPAPTVTWY------HE---DVIVQESKLSELMIRRVKQVDGGVYICVAEN 228
Query: 366 SKGE 369
G+
Sbjct: 229 QYGK 232
>UniRef50_P16234 Cluster: Alpha-type platelet-derived growth factor
receptor precursor; n=55; Vertebrata|Rep: Alpha-type
platelet-derived growth factor receptor precursor - Homo
sapiens (Human)
Length = 1089
Score = 289 bits (709), Expect = 3e-76
Identities = 183/546 (33%), Positives = 284/546 (52%), Gaps = 33/546 (6%)
Query: 454 LHCEAEGVPRPTIYWY--KDDELISNNSGYKLFVDIVNHTIVN------STFE--IENMQ 503
+ C AEG P P I W KD + +N + + + + V++ I ST E + +
Sbjct: 433 VRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAK 492
Query: 504 EKDNGIYECVALNNASELRRAYTLVLKAEKS-YTPYXXXXXXXXXXXXGMVAYLFTWKLK 562
++ C+A N R LV +S T ++ + WK K
Sbjct: 493 VEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQK 552
Query: 563 KQRELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGV 622
+ E+ + ++ S + + + +D LPYD ++EFPR+ L G+ LG+GAFG
Sbjct: 553 PRYEI-RWRVIESISPDGHEY---IYVDPMQ--LPYDSRWEFPRDGLVLGRVLGSGAFGK 606
Query: 623 VYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTK 682
V + A G+ ++ VAVKM+K TA + +AL SELKIM HLG H+NIVNLLGACTK
Sbjct: 607 VVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTK 666
Query: 683 HIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDNAEKNLG--KINKGFLNS----VG 736
+ +I EYC YG++ NY+ K+R+ F+ + +K L +N ++ +
Sbjct: 667 ---SGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVIL 723
Query: 737 TTGTHSDYFSSGNTKDTDHSLLYSGN--SKRSG--RKVSEGYIQQEWQTKYEGDY--IYE 790
+ + DY T + + SK S R + + + ++ + + +
Sbjct: 724 SFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLS 783
Query: 791 CHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSM 850
LT LL + +Q+ARGME+LA++ +H DLAARNVLLA +VKICDFGLAR +
Sbjct: 784 DDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDI 843
Query: 851 YNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS-PT 909
++ Y K ++ LPVKW+A E + D +++T SDVWSYGI+LWE+FSL TPYP + +
Sbjct: 844 MHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDS 903
Query: 910 DLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYV 969
+ G R+ KP A +Y +M++CW+ +P RPSF L EI+ N L + Y
Sbjct: 904 TFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYE 963
Query: 970 DLNAPY 975
++ +
Sbjct: 964 KIHLDF 969
Score = 89.8 bits (213), Expect = 4e-16
Identities = 85/334 (25%), Positives = 150/334 (44%), Gaps = 28/334 (8%)
Query: 4 IVVPRDCSKIVIECRPTTPDVNVTLSSEIPDYYYPSFRYSPKIGFVPENSMPSDDQIISF 63
+V+ D +I CR T P+ VTL + + P+ Y + GF + +
Sbjct: 137 LVIVEDDDSAIIPCRTTDPETPVTLHNS--EGVVPA-SYDSRQGF-------NGTFTVGP 186
Query: 64 VLCEF-VRGET--RIEKYIYVSKHIKKPPKPKVAGGHKQFLEGETFTIHCRVPNDGLINF 120
+CE V+G+ I +Y K + ++ + GET + C V N+ +++
Sbjct: 187 YICEATVKGKKFQTIPFNVYALKATSELDL-EMEALKTVYKSGETIVVTCAVFNNEVVDL 245
Query: 121 KWKYPPEVTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEKDE 180
+W YP EV +++++ + +VY +T+ AT K +G Y C E K E
Sbjct: 246 QWTYPGEVKGKG--ITMLEEIKVPSIKLVY-TLTVPEATVKDSGDYECAARQATREVK-E 301
Query: 181 FRKIFL---EKPFLSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDKYLPSN- 236
+K+ + EK F+ ++ N ++ + V+E+ AYPP R +LKN+ L N
Sbjct: 302 MKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPP-PRISWLKNNLTLIENL 360
Query: 237 -DLKYNVTTL--ANGDPKLRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAKLL 293
++ +V + KL++ K D +YT+VA+N+ K+YT +L T+ + +L
Sbjct: 361 TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFEL--LTQVPSSIL 418
Query: 294 NNRIIKRLENSEMNFACKVTGYPLPDVTWIFSND 327
+ C G PLPD+ W+ D
Sbjct: 419 DLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKD 452
>UniRef50_Q9VLQ8 Cluster: CG8222-PA, isoform A; n=8; Sophophora|Rep:
CG8222-PA, isoform A - Drosophila melanogaster (Fruit
fly)
Length = 1509
Score = 278 bits (681), Expect = 7e-73
Identities = 158/386 (40%), Positives = 228/386 (59%), Gaps = 21/386 (5%)
Query: 736 GTTGTHSDYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQEWQTKYEGDYIYECHQPR 795
G TG+ + +S DT +++ + + +S +Q W++ Y+ D +
Sbjct: 1046 GRTGSGTATYSYDRQMDTCATVMTT--VPEDDQIMSNNSVQPAWRSNYKTDST----EAM 1099
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
+T+ L+ WAFQ+ARGM+YL+++KVLHGDLAARN+LL +DNVVKICDFGLARSMY +
Sbjct: 1100 TVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDN 1159
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPT-DLLRW 914
Y+K EN LP+KWLA+E + D +FST SDVWSYGIVLWEMFSLAK PYP I P +L
Sbjct: 1160 YKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNK 1219
Query: 915 LSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLNAP 974
L+DG R+EKP FA+ LY +ML CW + P +RP F EL++ N L ++ + Y+DLN P
Sbjct: 1220 LNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRFANMLGEDVASHYLDLNNP 1279
Query: 975 YNEMNAELMTGE--DYLAMVCAPDYNNIVTPSPNYVNMAKSFFPATPTPKDQEGYLPMSP 1032
Y + N E M + DYLA++ +PD + +P YVN P + + Y+ MS
Sbjct: 1280 YMQSNIEYMKKQSTDYLALMGSPD--ELAPAAPRYVN--GHIVPDIRIEELPDDYMEMSR 1335
Query: 1033 TSDQTKYMA--HGTKFDFDSRKLNPRVSEAS-NV-GSVITPLLDLNNLPARSGSESDHEN 1088
SD A T+ + +S SE + N G+ +P L NNL + S +N
Sbjct: 1336 DSDPDACTAIFSPTRLEGESSDFPDFSSETTFNFPGARQSPTLS-NNLNSGSSKPLRKKN 1394
Query: 1089 NASTYLDKCIDDKKSDEVFEMKQTNT 1114
T +D + D+ +E+ + +++T
Sbjct: 1395 GMPT-VD--VADQAPEEIPMLHRSST 1417
Score = 235 bits (574), Expect = 7e-60
Identities = 122/277 (44%), Positives = 175/277 (63%), Gaps = 13/277 (4%)
Query: 450 RSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVN-STFEIENMQEKDNG 508
++++L C + VP + W+KDD+ ++ + + H I S I ++ D G
Sbjct: 711 QTLELECASTAVPVAIVRWFKDDKEVTESK--------LRHIIEKESKLLITHLYPGDEG 762
Query: 509 IYECVALNNASELRRAYTLVLKAEKSYT-PYXXXXXXXXXXXXGMVAYL---FTWKLKKQ 564
+Y+CV N + R++T+V+ + + G+ +L + + K+
Sbjct: 763 VYKCVVENRLDRIERSFTVVISDLPGISMAWVWFGVILFLILIGLCVFLAVRYQKEHKRH 822
Query: 565 RELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVY 624
L AGL NF+ G NP+L +DEQA+LLPY+ +FEFPRE L GKQLGAGAFGVV
Sbjct: 823 LALKAAGLANFEEGAVGHINPDLTLDEQAELLPYNREFEFPRENLKLGKQLGAGAFGVVL 882
Query: 625 KAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHI 684
K EA+GI E TT VAVKMVK TADN ++AL SELKIMVHLG+H+N+VNLLGA TK+I
Sbjct: 883 KGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNI 942
Query: 685 AKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDNAE 721
AKREL+VIVEYC++GNI N++ ++R+ FI+Q+ + +
Sbjct: 943 AKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTD 979
Score = 41.5 bits (93), Expect = 0.13
Identities = 23/95 (24%), Positives = 47/95 (49%), Gaps = 7/95 (7%)
Query: 435 IREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDD--ELISNNSGYKLFVDIVNHTI 492
+ EP + + + R+IQ+ EG P P+ W+K D E+ + + +K+ T
Sbjct: 374 VGEPSGHYNVQEYANRTIQMTANFEGFPTPSFSWFKPDGTEVRQSENNFKIL-----STE 428
Query: 493 VNSTFEIENMQEKDNGIYECVALNNASELRRAYTL 527
+++ ++ N Q +D+G Y N+ ++R Y +
Sbjct: 429 LSTMLQVLNAQLQDSGTYVLRGSNSFGVVQREYNV 463
>UniRef50_P79749 Cluster: Beta-type platelet-derived growth factor
receptor precursor; n=9; Clupeocephala|Rep: Beta-type
platelet-derived growth factor receptor precursor - Fugu
rubripes (Japanese pufferfish) (Takifugu rubripes)
Length = 1048
Score = 277 bits (679), Expect = 1e-72
Identities = 153/399 (38%), Positives = 229/399 (57%), Gaps = 28/399 (7%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIK 655
LPYD +E PR+ L G+ LG+GAFG V +A A G+ +++ + VAVKM+K TA +
Sbjct: 583 LPYDLAWEMPRDNLVLGRTLGSGAFGRVVEATAHGLSHSQSSIKVAVKMLKATARRSETQ 642
Query: 656 ALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQ 715
AL SELKIM HLG H+NIVNLL ACTKH L ++ EYC+YG++ +Y+ +++ F+
Sbjct: 643 ALMSELKIMSHLGPHLNIVNLLAACTKH---GPLYLVTEYCRYGDLVDYLHRNKHTFLQY 699
Query: 716 LTDNAEKNLGKINKGFLNSVGTT--GTHSDYFSSGNTKD-------TDHSLLYSGNSKRS 766
D + + G L S G+T Y S G+ D D +Y ++
Sbjct: 700 YLDKNQDD------GSLISGGSTPLSQRKGYVSFGSESDGGYMDMSKDEPAVYVPMQEQM 753
Query: 767 GRKVSEGYIQQEWQTKYEGDYIYECHQPR---------PLTSGHLLGWAFQIARGMEYLA 817
+++ Y+ D E R LT LLG+++Q+A+GME+LA
Sbjct: 754 DTIKYADIQPSPYESPYQQDLYQEQGGGRVDLVISDSPALTYDDLLGFSYQVAKGMEFLA 813
Query: 818 NRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDR 877
++ +H DLAARNVL+ + +VKICDFGLAR + ++ Y K ++ LP+KW+A E +
Sbjct: 814 SKNCVHRDLAARNVLICEGKLVKICDFGLARDIMHDSNYISKGSTFLPLKWMAPESIFHN 873
Query: 878 IFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLL-RWLSDGNRLEKPPFADDRLYNVML 936
+++T SDVWSYGI+LWE+F+L TPYP++ +L L G R+ KP A D +Y +M
Sbjct: 874 LYTTLSDVWSYGILLWEIFTLGGTPYPDLPMNELFYSPLKRGYRMAKPAHASDEVYEIMK 933
Query: 937 RCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLNAPY 975
RCW + RP F+ L +G+ L D+ + +Y +N +
Sbjct: 934 RCWDETFEKRPDFSFLVHCVGDMLTDSYKKKYSQVNETF 972
Score = 65.7 bits (153), Expect = 7e-09
Identities = 85/396 (21%), Positives = 154/396 (38%), Gaps = 36/396 (9%)
Query: 5 VVPRDCSKIVIECRPTTPDVNVTLSSEIPDYYYPSFRYSPKIG-FVPENSMPSDDQIISF 63
+V + + + C T P++ VTL + D P G +VP + ++
Sbjct: 141 MVTKTSGESTVPCVVTNPNITVTLYDKDTDL--------PVNGVYVPSEGFKAYLDYRTY 192
Query: 64 VLCEFVRGETRIEKYIYV-SKHIKKPPKPKVAGGHKQFLEGETFTIHCRVPNDGLINFKW 122
V + GE + + V S H+ + V +GE T++C V L+ F W
Sbjct: 193 VCRGELNGEVKESQAFNVYSIHVPEDIDAYVNASQTVLKQGEPLTVNCTVQGVELVLFSW 252
Query: 123 KYPPEVTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEKDEFR 182
P +VV + T +V+ + T+ H+G Y C + ++K F
Sbjct: 253 DIPNRDIVKHKPETVVLSATTMRSCLVFPHATVA-----HSGTYVCHAHESTQDQK-AFA 306
Query: 183 KI---FLEKPFLSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDKYLPSNDLK 239
+ LE+ F++++ K + +++ + +EIEAYPP + K D ++
Sbjct: 307 SVNITVLERGFVAVKSTRKQNITAELQENVELRVEIEAYPPPQIR--WKKD----GAPVR 360
Query: 240 YNVTTLANGDPKLR-INDLKLTDIAN-----YTLVAENKYLTKNYTVDLRVFTKPEAKLL 293
+ T + + ++R + L L + YT + N+ K T L V K L
Sbjct: 361 GDKTIIIRQEHEIRYVTILTLVRVRTEQKGLYTALITNEDDVKEVTFALEVQVLARIKDL 420
Query: 294 NNRIIKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYLKISV 353
+ L + C G P P + W +S D + ++ S + L A + L I
Sbjct: 421 TDH---HLPGKKQLVTCVAEGVPTPTIQW-YSCDSMLKCNNQTSLWQQLKADPELLSIHT 476
Query: 354 QASGVITCNAHNSKGEYF-DSSTLLVYEINNGFGIL 388
+ N S+ +F T + E N G++
Sbjct: 477 SVTEARQTNQVRSQVTFFKPQHTTVRCETTNQEGLI 512
Score = 36.3 bits (80), Expect = 4.9
Identities = 15/38 (39%), Positives = 22/38 (57%)
Query: 447 MEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLF 484
+ G+ + C AEGVP PTI WY D ++ N+ L+
Sbjct: 425 LPGKKQLVTCVAEGVPTPTIQWYSCDSMLKCNNQTSLW 462
>UniRef50_P10721 Cluster: Mast/stem cell growth factor receptor
precursor; n=88; root|Rep: Mast/stem cell growth factor
receptor precursor - Homo sapiens (Human)
Length = 976
Score = 277 bits (678), Expect = 2e-72
Identities = 183/536 (34%), Positives = 278/536 (51%), Gaps = 40/536 (7%)
Query: 454 LHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTF-------EIENMQEKD 506
L C A G P PTI WY S L VD+ F I++ K
Sbjct: 426 LQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKH 485
Query: 507 NGIYECVALNNASELRRAYTLVLKA--EKSYTPYXXXX--XXXXXXXXGM---VAYLFTW 559
NG EC A N+ + + K ++ P+ GM + + T+
Sbjct: 486 NGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTY 545
Query: 560 K-LKKQRELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAG 618
K L+K + ++ +GN + ID LPYD K+EFPR +L+FGK LGAG
Sbjct: 546 KYLQKPMYEVQWKVVEEINGNNYVY-----IDPTQ--LPYDHKWEFPRNRLSFGKTLGAG 598
Query: 619 AFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLG 678
AFG V +A A G+I ++ VAVKM+K +A +AL SELK++ +LG H+NIVNLLG
Sbjct: 599 AFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLG 658
Query: 679 ACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFI-DQLTDNAEKNLGKINKGFLNSVGT 737
ACT +VI EYC YG++ N++++ R+ FI + D+AE L K L+S +
Sbjct: 659 ACT---IGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAAL---YKNLLHSKES 712
Query: 738 TGTHSDYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPL 797
+ + S + + + +RS R S YI+++ D L
Sbjct: 713 SCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGS--YIERDVTPAIMED------DELAL 764
Query: 798 TSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQ 857
LL +++Q+A+GM +LA++ +H DLAARN+LL + KICDFGLAR + N+ Y
Sbjct: 765 DLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYV 824
Query: 858 KKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTD--LLRWL 915
K N+ LPVKW+A E + + +++ +SDVWSYGI LWE+FSL +PYP + P D + +
Sbjct: 825 VKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGM-PVDSKFYKMI 883
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDL 971
+G R+ P A +Y++M CW P RP+F ++ +++ + ++ + Y +L
Sbjct: 884 KEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNL 939
Score = 65.7 bits (153), Expect = 7e-09
Identities = 72/318 (22%), Positives = 135/318 (42%), Gaps = 40/318 (12%)
Query: 76 EKYIY-VSKHIKKPPKPKVAGGHKQFLEGETFTIHCRVPN-DGLINFKWKYPPEVTNDSV 133
EK+I V K P V+ EGE FT+ C + + + WK N
Sbjct: 198 EKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRE----NSQT 253
Query: 134 EVSVVKTEATTTGSIVYQN---ITIRNATKKHNGVYTCLLTNTCGEEKDEFRKIFLEKPF 190
++ K + G Y+ +TI +A +GV+ C NT G ++K F
Sbjct: 254 KLQE-KYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGF 312
Query: 191 LSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLK-----NDKY--LPSNDLKYNVT 243
+++ + + N +++++++E EA+P E ++ DK+ P ++ + N+
Sbjct: 313 INIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIR 372
Query: 244 TLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRLEN 303
++ +L + LK T+ YT + N + ++ V TKPE L +R++ +
Sbjct: 373 YVS----ELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEI-LTYDRLVNGM-- 425
Query: 304 SEMNFACKVTGYPLPDVTWIFSNDEEHELSST--KSEQESLYAK-TDYLKISVQAS---- 356
C G+P P + W F E S++ + ++L + + K+ VQ+S
Sbjct: 426 ----LQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSS 481
Query: 357 -----GVITCNAHNSKGE 369
G + C A+N G+
Sbjct: 482 AFKHNGTVECKAYNDVGK 499
>UniRef50_Q8JFR5 Cluster: Mast/stem cell growth factor receptor
precursor; n=17; Clupeocephala|Rep: Mast/stem cell
growth factor receptor precursor - Danio rerio
(Zebrafish) (Brachydanio rerio)
Length = 976
Score = 277 bits (678), Expect = 2e-72
Identities = 189/575 (32%), Positives = 298/575 (51%), Gaps = 52/575 (9%)
Query: 416 SWLGSDGNILDDIELLAPIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELI 475
S L D I E+ +I +P E ++G Q+ C AEG P P I WY D
Sbjct: 387 SCLNRDATIRQTFEV--HVISKPQIVSYEGPIDG---QVRCVAEGYPTPQIKWYYCDLPH 441
Query: 476 SNNSGYKLFV----DIVNHTIVNSTF---EIE---NMQEKDNGIYECVALNNASELRRAY 525
S S D+V T+ N F +E N+ + + ECVA N + +
Sbjct: 442 SRCSNLLNATQEEEDVVTVTMTNPPFGKGAVESRLNITKNNYATLECVASANGEIVYTLF 501
Query: 526 TLVLKA--EKSYTPYXXXXXXXXXXXXGMVAYLFTWK-LKKQRELTKAGLLNFKSGNKKS 582
++ + +TP ++ + T+K ++K + + ++ GN
Sbjct: 502 SISENTVPHELFTPLLIGFVAAAVILV-LILIVLTYKYMQKPKYQIQWKVIEGIHGNNYV 560
Query: 583 FNPNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAV 642
+ ID LPYD ++EFPR+KL FGK LG+GAFG V +A A G+ A+ VAV
Sbjct: 561 Y-----IDPTQ--LPYDHQWEFPRDKLRFGKTLGSGAFGKVVEATAYGMSKADTVMTVAV 613
Query: 643 KMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIH 702
KM+K +A +AL SELK++ +LG H+NIVNLLGACT +VI EYC +G++
Sbjct: 614 KMLKPSAHATEKEALMSELKVLSYLGNHINIVNLLGACT---VGGPTLVITEYCCFGDLL 670
Query: 703 NYMQKHREVFIDQLTDNAEKNLGKINKGFLNSVGTTGTHSDYFSSGNTKDTDHSLLYSGN 762
N++++ R F LG+ + +V +D + T + S
Sbjct: 671 NFLRRRRVYFY-------YTTLGE--DAYYRNVMMQSEPNDSRNGYMTMKPSVLGILSSE 721
Query: 763 SKRSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLT--SGHLLGWAFQIARGMEYLANRK 820
++RS K + Y + D + E Q LT + LL +++Q+A+GM++LA++
Sbjct: 722 NRRSLNK-GDSYS--------DSDAVSEILQEDGLTLDTEDLLSFSYQVAKGMDFLASKN 772
Query: 821 VLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFS 880
+H DLAARN+LL V KICDFGLAR + + Y K N+ LPVKW++ E + + +++
Sbjct: 773 CIHRDLAARNILLTQGRVAKICDFGLARDITTDSNYVVKGNARLPVKWMSPESIFECVYT 832
Query: 881 TQSDVWSYGIVLWEMFSLAKTPYPNISPTD--LLRWLSDGNRLEKPPFADDRLYNVMLRC 938
+SDVWSYGI+LWE+FSL +PYP + P D + + +G R+E P F+ +Y++M C
Sbjct: 833 FESDVWSYGILLWEIFSLGSSPYPGM-PVDSKFYKMIKEGYRMESPEFSPSEMYDIMHSC 891
Query: 939 WHQKPTARPSFTELQEILGNFLEDNERNRYVDLNA 973
W P RPSF+++ E + + D+ ++ Y++ ++
Sbjct: 892 WDADPVKRPSFSKIVEKIEQQISDSTKHIYLNFSS 926
Score = 59.3 bits (137), Expect = 6e-07
Identities = 69/328 (21%), Positives = 130/328 (39%), Gaps = 18/328 (5%)
Query: 5 VVPRDCSKIVIECRPTTPDV-NVTLSSEIPDYYYPSFRYSPKIGF-VPENSMPSDDQIIS 62
+V + VI C T PD+ N+ L S RYS + V + + +
Sbjct: 119 IVAAEGDTTVIPCLATDPDMKNLNLQKCDGQPLPNSLRYSASLETGVSVEKVRKEFEGCY 178
Query: 63 FVLCEFVRGETRIEKYIYVSKHIKKPPKPKVAGGHKQFL--EGETFTIHCRVPN-DGLIN 119
+ + +Y + + P P G ++ L +GE ++ C N + I
Sbjct: 179 VCVGTLDAATVKSGRYQLTVRLVPDAPPPITLGQPQRVLLTQGEKLSLSCSTSNVNSDIA 238
Query: 120 FKWKYPPEVTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEKD 179
KWK P V + S + TE T + +++ + T + G Y+C N G
Sbjct: 239 VKWKAPNGVNPSVHQNSHLLTEPIT--HVRTAILSLSSVTMQDAGNYSCEAINEKGTTAK 296
Query: 180 EFRKIFLEKPFLSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDKYLPSNDLK 239
EK F+++ + A +S+++ + + AYP + + L +N
Sbjct: 297 PVWVNIYEKGFINITSVDNSTRRVRAGESLSLRVVMNAYPKPHTFSWSYSGVKL-TNTTD 355
Query: 240 YNVTTLANGDP---KLRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAKLLNNR 296
+ +T+ +G+ +L++ LK+++ YT N+ T T ++ V +KP+
Sbjct: 356 HVITSRTHGNSYTSELKLVRLKVSESGIYTFSCLNRDATIRQTFEVHVISKPQ------- 408
Query: 297 IIKRLENSEMNFACKVTGYPLPDVTWIF 324
I+ + C GYP P + W +
Sbjct: 409 IVSYEGPIDGQVRCVAEGYPTPQIKWYY 436
>UniRef50_UPI0001555344 Cluster: PREDICTED: similar to Kinase insert
domain receptor; n=1; Ornithorhynchus anatinus|Rep:
PREDICTED: similar to Kinase insert domain receptor -
Ornithorhynchus anatinus
Length = 1048
Score = 275 bits (674), Expect = 5e-72
Identities = 181/504 (35%), Positives = 273/504 (54%), Gaps = 42/504 (8%)
Query: 491 TIVNSTFEIENMQEKDNGIYECVALNNASELRRAYTLVLKAEKSYTPYXXXXXXXXXXXX 550
++ N T IE ++ D G YEC A N + + + ++ + +
Sbjct: 424 SLENRTLVIERAKKDDEGTYECQATNEVGQASTSAVITVEGLEERS----NIEVIILVCT 479
Query: 551 GMVAYLFTWKLKKQ--RELTKAGLLNFKSGNKKSF-NPN-LGIDEQADLLPYDE-KFEFP 605
G+ A LF W L R+L K + + K+G +P + LPYD ++EFP
Sbjct: 480 GLAATLF-WLLLTLFIRKLRKPNVSDIKTGYLSIIMDPEEXXXXXXCERLPYDSSRWEFP 538
Query: 606 REKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMV 665
R++L GK LG GAFG V +A A GI + VAVKM+K A KAL SELKI++
Sbjct: 539 RDRLRLGKTLGHGAFGKVVEASAFGIDKSSTCKTVAVKMLKECATTNECKALMSELKILI 598
Query: 666 HLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFI--DQLTDNAEKN 723
H+G H+N+VNLLGACTK + L+VIVE+CKYGN+ NY++ R FI + ++ EK+
Sbjct: 599 HIGHHLNVVNLLGACTK--SGGPLMVIVEFCKYGNLSNYLRGKRGDFIAFKEGSEPGEKS 656
Query: 724 LGKINKGFLNSVGTTGTHSDYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQEWQTKY 783
L + + G L + K S+ +G+S SG + Y E + +
Sbjct: 657 L-EDSSGDLTEL--------------IKRRLESVASTGSSASSGFIEHKSYSDSE-EEEX 700
Query: 784 EGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+ + +Y+ R LT L+ ++FQ+A+GME+LA+RK +H DLAARN+LL+++NVVKICD
Sbjct: 701 DSEDLYK----RLLTLEDLICYSFQVAKGMEFLASRKCIHRDLAARNILLSENNVVKICD 756
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIF-STQSDVWSYGIVLWEMFSLAK-- 900
FGLAR +Y + +Y +K +S P+KWLA E + D ++ T+ + S +WE S +
Sbjct: 757 FGLARDIYKDPDYVRKGDSRWPLKWLAQESLSDSLWGGTRLPILSVPRAIWEGLSYLRGG 816
Query: 901 -TPYPNIS-PTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGN 958
+PYP + + R L +G R+ P ++ +Y ML CW + RP+FTEL E LG+
Sbjct: 817 ASPYPGVQIDEEFCRRLKEGTRMRSPEYSTPEIYQTMLDCWRGPCSERPNFTELVERLGD 876
Query: 959 FLE---DNERNRYVDLNAPYNEMN 979
L+ E Y+ LN +N
Sbjct: 877 LLQASVQQEGKEYIPLNITDGGLN 900
>UniRef50_Q640T5 Cluster: Tyrosine-protein kinase receptor; n=2;
Xenopus tropicalis|Rep: Tyrosine-protein kinase receptor
- Xenopus tropicalis (Western clawed frog) (Silurana
tropicalis)
Length = 935
Score = 275 bits (674), Expect = 5e-72
Identities = 174/525 (33%), Positives = 273/525 (52%), Gaps = 38/525 (7%)
Query: 456 CEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIYECVAL 515
C A G P P I W K E + K + N + + +N+ + V
Sbjct: 414 CTASGYPLPKIEWSKCSENKICHENIKQPMTNYNIIVESHLTVTQNITSIVCKAFNSVGE 473
Query: 516 NNAS-ELRRAY-TLVLKAEKSYTPYXXXXXXXXXXXXGMVAYLFTWKLKKQRELTKAGLL 573
++ EL R + T EK +TP + A+L+ +K + + ++
Sbjct: 474 DSREMELPRTFETSRPDQEKLFTPIVISSLILAGIFIVLSAFLYYKYQQKPKYEIRWQII 533
Query: 574 NFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIIN 633
GN + ID LPY++K+EFPR L FGK LGAGAFG V +A A G+ N
Sbjct: 534 QPAEGNNYTC-----IDPTQ--LPYNDKWEFPRTNLQFGKTLGAGAFGKVMEATAVGLGN 586
Query: 634 AEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIV 693
+ VAVKM+K +A ++AL SELKI+ HLG H NIVNLLGACT ++VI
Sbjct: 587 EDSAVTVAVKMLKPSAHTDEVEALMSELKILSHLGNHKNIVNLLGACTHG---GPILVIT 643
Query: 694 EYCKYGNIHNYMQKHREVFIDQLTDNAEKNLGKINKGFLNSVGTTGTHSDYFSSGNTKDT 753
EYC YG++ N+++K ++ + + + E+ + T SDY
Sbjct: 644 EYCHYGDLLNFLRKKAQIMNEMFSASLEEQ--------------SSTSSDY----KNMTI 685
Query: 754 DHSLLYSGNSKRSGRKVSEGYIQQEWQTKY--EGDYIYE---CHQPRPLTSGHLLGWAFQ 808
+H + S + S K ++ Y++ + + +GD + + PL LL ++FQ
Sbjct: 686 EHKYIKSDSGFLS--KGTDSYVEMKPVSSLSSQGDSLIDEKDTDDMLPLDLYDLLSFSFQ 743
Query: 809 IARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKW 868
+++GM +L+ + +H D+AARNVL++ VVKICDFGLAR + N+ Y K N+ LPVKW
Sbjct: 744 VSQGMSFLSAKNCIHRDVAARNVLVSHGRVVKICDFGLARDIENDSNYVVKGNARLPVKW 803
Query: 869 LAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPT-DLLRWLSDGNRLEKPPFA 927
+A E + D +++ QSDVWSYGI+LWEMFSL ++PYP I + + +G +++ P +A
Sbjct: 804 MAPESIFDCVYTVQSDVWSYGILLWEMFSLGRSPYPGIMVNRKFYKMIKEGYKMDCPDYA 863
Query: 928 DDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLN 972
+Y +M CW +PT RP+F ++ ++ + Y +++
Sbjct: 864 PLEIYRIMKTCWDLEPTQRPTFNQISTLISKQINILNNQDYANIS 908
Score = 62.5 bits (145), Expect = 6e-08
Identities = 76/380 (20%), Positives = 155/380 (40%), Gaps = 34/380 (8%)
Query: 4 IVVPRDCSKIVIECR---PTTPDVNVTLSSEIPDYYYPSFRYSPKIGFVPENSMPSDDQI 60
+V + +V+ C P+ P N+ L S + SF Y GF +D +
Sbjct: 114 VVKMEEGKDVVLPCLITDPSIPRANIQLESSSLNSANISFDYHK--GFTIHGVQMENDGM 171
Query: 61 ISFVLCEFVRGETR--IEKYIYVSKHIKKPPKPKVAGGHKQFLEGETFTIHCRVPNDGLI 118
++ V G R +E ++V + + PP + + ++GE F I C+ L
Sbjct: 172 --YICKATVNGHVRKSLEMRLFVIEVPRLPPNVTMEPQNDIRIKGEAFKITCKATGKVLP 229
Query: 119 NFKWKYPPEVTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCL--LTNTCGE 176
+W+ P + + + TTT ++ + ++ G YTC+ + +
Sbjct: 230 VLRWETPATDYTVTNTTRLTLMDWTTTSTLYIHKVNFTDS-----GNYTCIGYYPSYASQ 284
Query: 177 EKDEFRKIF-LEKPFLSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDKYLPS 235
K + +E+ ++ L L ++ A +S NI I I+AYP ++ + S
Sbjct: 285 LKRISTSLHVIEEGYVRLTTLGNNRITLRAGESTNITILIDAYPSQLSWAWIHENHGNQS 344
Query: 236 NDLKYNVTTLANGDPK----LRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAK 291
N + +G + L++N + + +YT A+N + + V +P
Sbjct: 345 N-VSSQAVVKPDGHYRNVTILQLNRILEYEEGSYTFTAQNARANASLAFKI-VLNRPP-- 400
Query: 292 LLNNRIIKRLENSEMNFACKVTGYPLPDVTWIFSNDEE--HELSSTKSEQESLYAKTDYL 349
++ ++ + + C +GYPLP + W ++ + HE ++ ++ +L
Sbjct: 401 -----VVNKMWSINNTYTCTASGYPLPKIEWSKCSENKICHENIKQPMTNYNIIVES-HL 454
Query: 350 KISVQASGVITCNAHNSKGE 369
++ + ++ C A NS GE
Sbjct: 455 TVTQNITSIV-CKAFNSVGE 473
>UniRef50_Q9U8U8 Cluster: VEGFR-like; n=1; Branchiostoma
belcheri|Rep: VEGFR-like - Branchiostoma belcheri
(Amphioxus)
Length = 445
Score = 272 bits (666), Expect = 5e-71
Identities = 154/351 (43%), Positives = 206/351 (58%), Gaps = 39/351 (11%)
Query: 623 VYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTK 682
V +A A GI + + VAVKM+K A + +KAL ELKI++H+G+H+NIVNLLGACTK
Sbjct: 2 VIEATAFGIEKDKQCSTVAVKMLKDDASSNEVKALMDELKILIHIGQHLNIVNLLGACTK 61
Query: 683 HIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDNAEKNLGKINKGFLNSVGTTGTHS 742
L VIVE CKYGN+ NY++ GK KGF+ S
Sbjct: 62 D---GPLYVIVECCKYGNLSNYLR------------------GK-RKGFVES-------K 92
Query: 743 DYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHL 802
D N+ D+ + + R VS+ + +Y Y C PLT L
Sbjct: 93 DQRDRSNSSGYDNCRYVDSPNGKCLRTVSKEGLM---------NYDYTCDDGEPLTLEDL 143
Query: 803 LGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENS 862
+ +++Q+ARGM+YLA++K +H DLAARNVLLA NVVKICDFGLAR +Y N EY K N+
Sbjct: 144 VSYSYQVARGMDYLASKKCIHRDLAARNVLLAKHNVVKICDFGLARDVYRNPEYIKMGNA 203
Query: 863 PLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS-PTDLLRWLSDGNRL 921
PLPVKW+A E + DR ++ QSDVWSYG++LWE+F L +PYP + D L G R+
Sbjct: 204 PLPVKWMAPESIFDRSYTIQSDVWSYGVLLWEIFELGGSPYPGVQINEDFFDKLRQGFRM 263
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLN 972
+P A D LY +ML CW +PT RP+FT+L E + + LE Y+DL+
Sbjct: 264 RQPKHASDDLYQMMLSCWRMEPTERPTFTDLAESMSSQLEATAEQEYLDLS 314
>UniRef50_P09619 Cluster: Beta-type platelet-derived growth factor
receptor precursor; n=25; Amniota|Rep: Beta-type
platelet-derived growth factor receptor precursor - Homo
sapiens (Human)
Length = 1106
Score = 265 bits (650), Expect = 4e-69
Identities = 144/397 (36%), Positives = 229/397 (57%), Gaps = 23/397 (5%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIK 655
LPYD +E PR++L G+ LG+GAFG V +A A G+ +++ T VAVKM+K TA + +
Sbjct: 587 LPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQ 646
Query: 656 ALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQ 715
AL SELKIM HLG H+N+VNLLGACTK + +I EYC+YG++ +Y+ +++ F+
Sbjct: 647 ALMSELKIMSHLGPHLNVVNLLGACTKG---GPIYIITEYCRYGDLVDYLHRNKHTFLQH 703
Query: 716 LTDNAEKNLGKINKGFL-------NSVGTTG-THSDYFSSGNTKDTDH--SLLYSGNSKR 765
+D ++ L + V TG + Y + D+ L G+ K
Sbjct: 704 HSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKY 763
Query: 766 SGRKVS------EGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANR 819
+ + S + Y+ + I E P L+ L+G+++Q+A GME+LA++
Sbjct: 764 ADIESSNYMAPYDNYVPSAPERTCRATLINE--SP-VLSYMDLVGFSYQVANGMEFLASK 820
Query: 820 KVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIF 879
+H DLAARNVL+ + +VKICDFGLAR + + Y K ++ LP+KW+A E + + ++
Sbjct: 821 NCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLY 880
Query: 880 STQSDVWSYGIVLWEMFSLAKTPYPNISPTD-LLRWLSDGNRLEKPPFADDRLYNVMLRC 938
+T SDVWS+GI+LWE+F+L TPYP + + + G R+ +P A D +Y +M +C
Sbjct: 881 TTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKC 940
Query: 939 WHQKPTARPSFTELQEILGNFLEDNERNRYVDLNAPY 975
W +K RP F++L +L L + + +Y ++ +
Sbjct: 941 WEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEF 977
Score = 58.8 bits (136), Expect = 8e-07
Identities = 69/326 (21%), Positives = 132/326 (40%), Gaps = 20/326 (6%)
Query: 9 DCSKIVIECRPTTPDVNVTLSSEIPDYYYPSFRYSPKIGFVPENSMPSDDQIISFVLCEF 68
+ ++I I CR T P + VTL + D P Y + GF S +D+ S++ C+
Sbjct: 141 EITEITIPCRVTDPQLVVTLHEKKGDVALP-VPYDHQRGF----SGIFEDR--SYI-CKT 192
Query: 69 VRGETRIEKYIYVSKHIKKPP-KPKVAGGHKQFLEGETFTIHCRVPNDGLINFKWKYPPE 127
G+ ++ Y ++ V +GE T+ C V + ++NF+W YP +
Sbjct: 193 TIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRK 252
Query: 128 VTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEKDE--FRKIF 185
+ VE V + + I +A + +G YTC +T + + +DE
Sbjct: 253 ESGRLVE--PVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITV 310
Query: 186 LEKPFLSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDKYLPSNDLKYNVTTL 245
+E ++ L ++S + + EAYPP F N S+ + ++T
Sbjct: 311 VESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTR 370
Query: 246 ANGDPK----LRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRL 301
+ + L + +K+ + +YT+ A ++ + L++ L+
Sbjct: 371 NVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSE---SHP 427
Query: 302 ENSEMNFACKVTGYPLPDVTWIFSND 327
++ E C+ G P P++ W D
Sbjct: 428 DSGEQTVRCRGRGMPQPNIIWSACRD 453
>UniRef50_Q1HTP1 Cluster: Tyrosine-protein kinase receptor; n=1;
Astatotilapia burtoni|Rep: Tyrosine-protein kinase
receptor - Haplochromis burtoni (Burton's mouthbrooder)
Length = 998
Score = 264 bits (646), Expect = 1e-68
Identities = 175/526 (33%), Positives = 271/526 (51%), Gaps = 50/526 (9%)
Query: 454 LHCEAEGVPRPTIYWYKDDEL------ISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDN 507
L C + G P PTI W+ + I+ N + V + V S F + D+
Sbjct: 467 LTCSSSGYPLPTILWFTCPGIQPSCAHIATNEVSQASVTSQDGEEVRSHFLLS---ADDD 523
Query: 508 GIYECVALNNASELRRAYTLVLKAEKSYTPYXXXXXXXXXXXXGMVAYLFTWKLKKQREL 567
ECVA N E R + + +TP ++ LF +K +
Sbjct: 524 VTVECVASNLMGESLRVFHH--RNPIIFTPPLIGVLSATAVLFLLLLVLFYKCRQKPKYE 581
Query: 568 TKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAE 627
+ ++ GN +F +D LPY++K+EFPR+KL G LG+GAFG V +A
Sbjct: 582 IRWKIIESTDGNNYTF-----VDPTQ--LPYNQKWEFPRDKLRLGPILGSGAFGKVVEAT 634
Query: 628 ARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKR 687
A G+ T VAVKM+K +A + +AL SELKI+ HLG H NIVNLLGACT+
Sbjct: 635 AYGLETDNKITRVAVKMLKPSAHSEEREALMSELKILSHLGYHDNIVNLLGACTRG---G 691
Query: 688 ELIVIVEYCKYGNIHNYMQKHREVFIDQLTDNAEKNLGKINKGFLNSVGTTGTHSDYFSS 747
+++I EYC +G++ N+++ + + + E + F ++
Sbjct: 692 PMLMITEYCSHGDLLNFLRGRAQDIVASMVTVDEVQ----EEAFYKNMAA---------- 737
Query: 748 GNTKDTDHSLLYSGNSKRSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAF 807
H+ L S SG Y QE Q ++ Q L+ L+ +++
Sbjct: 738 ------QHARLRSD----SGISCCSEY--QEMQPILSPGQTHQGVQTDGLSVSDLISFSY 785
Query: 808 QIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVK 867
Q+++G+++L+ R +H D+AARNVLL D V KICDFGLAR + N++ Y + N+ LPVK
Sbjct: 786 QVSQGLDFLSTRNCIHRDVAARNVLLTDRRVAKICDFGLARDIRNDDSYIVQGNARLPVK 845
Query: 868 WLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS-PTDLLRWLSDGNRLEKPPF 926
W+A E + +++ QSDVWSYG++LWE+FSL K+PYPNI+ T+ + + DG +E+P F
Sbjct: 846 WMAPESIFQCVYTVQSDVWSYGVLLWEIFSLGKSPYPNIAVDTNFYKMIKDGGHMEQPDF 905
Query: 927 ADDRLYNVMLRCWHQKPTARPSFTELQEILGNFL--EDNERNRYVD 970
A +Y +M CW +PT RP+F + +++ L ++ +RY D
Sbjct: 906 APAEMYQLMKLCWSLEPTHRPTFKTIGQLISRLLPSTNDMSSRYSD 951
Score = 45.6 bits (103), Expect = 0.008
Identities = 27/119 (22%), Positives = 54/119 (45%), Gaps = 12/119 (10%)
Query: 207 KSINIVIEIEAYPPVERTHFLKNDKYLPSNDLKYNVTTLANG---DPKLRINDLKLTDIA 263
+ + + ++AYPP+ + + ++ Y + AN + L ++ ++ D
Sbjct: 372 RDVALTFLLKAYPPITSQRWTTPTHLINNDSTVYQESYAANSYSLEATLLLHRMRPEDRG 431
Query: 264 NYTLVAENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRLENSEMNFACKVTGYPLPDVTW 322
Y N + + ++T+DL+V+ P + LENS + C +GYPLP + W
Sbjct: 432 QYLFHFSNSFFSGSHTIDLKVYRFPTTDIT-------LENSTLT--CSSSGYPLPTILW 481
>UniRef50_P36888 Cluster: FL cytokine receptor precursor; n=33;
Amniota|Rep: FL cytokine receptor precursor - Homo
sapiens (Human)
Length = 993
Score = 263 bits (644), Expect = 2e-68
Identities = 158/382 (41%), Positives = 217/382 (56%), Gaps = 18/382 (4%)
Query: 598 YDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKAL 657
YD K+EFPRE L FGK LG+GAFG V A A GI V+ VAVKM+K AD+ +AL
Sbjct: 599 YDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREAL 658
Query: 658 ASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLT 717
SELK+M LG H NIVNLLGACT + +I EYC YG++ NY++ RE F T
Sbjct: 659 MSELKMMTQLGSHENIVNLLGACT---LSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWT 715
Query: 718 DNAEKNLGKINKGFLNSVGTTGTHSDYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQ 777
+ +++ F + ++ S D+D GNS S E I+
Sbjct: 716 EIFKEHNFSFYPTFQSHPNSSMPGSREVQIH--PDSDQISGLHGNSFHS-----EDEIEY 768
Query: 778 EWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDN 837
E Q + E E LT LL +A+Q+A+GME+L + +H DLAARNVL+
Sbjct: 769 ENQKRLE-----EEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGK 823
Query: 838 VVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFS 897
VVKICDFGLAR + ++ Y + N+ LPVKW+A E + + I++ +SDVWSYGI+LWE+FS
Sbjct: 824 VVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFS 883
Query: 898 LAKTPYPNISPTD--LLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEI 955
L PYP I P D + + +G ++++P +A + +Y +M CW RPSF L
Sbjct: 884 LGVNPYPGI-PVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSF 942
Query: 956 LGNFLEDNERNRYVDLNAPYNE 977
LG L D E Y +++ +E
Sbjct: 943 LGCQLADAEEAMYQNVDGRVSE 964
>UniRef50_P07333 Cluster: Macrophage colony-stimulating factor 1
receptor precursor; n=35; root|Rep: Macrophage
colony-stimulating factor 1 receptor precursor - Homo
sapiens (Human)
Length = 972
Score = 262 bits (643), Expect = 3e-68
Identities = 179/532 (33%), Positives = 267/532 (50%), Gaps = 36/532 (6%)
Query: 454 LHCEAEGVPRPTIYWYK--------DDELISN--NSGYK--LFVDIVNHTIVNSTFEIEN 501
L C A G P+P + W + D+ + + Y L + + V S +E
Sbjct: 417 LLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVET 476
Query: 502 MQEKDNGIYECVALNNASELRRAYTLVLKAEKSYTPYXXXXXXXXXXXXGMVAYLFTWKL 561
++ N YEC A N+ A+ + ++ P ++A L L
Sbjct: 477 LEH--NQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLL 534
Query: 562 KKQRELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFG 621
+ + + +S+ N LPY+EK+EFPR L FGK LGAGAFG
Sbjct: 535 LLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFG 594
Query: 622 VVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACT 681
V +A A G+ + VAVKM+K TA +AL SELKIM HLG+H NIVNLLGACT
Sbjct: 595 KVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACT 654
Query: 682 KHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDNAEKNLGKINKGFLNSVGTTGTH 741
++VI EYC YG++ N++++ E + + G ++ ++
Sbjct: 655 HG---GPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR 711
Query: 742 SDYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGH 801
FSS + D + S S SE + +E +G RPL
Sbjct: 712 DSGFSS---QGVDTYVEMRPVSTSSNDSFSEQDLDKE-----DG---------RPLELRD 754
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
LL ++ Q+A+GM +LA++ +H D+AARNVLL + +V KI DFGLAR + N+ Y K N
Sbjct: 755 LLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGN 814
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNI-SPTDLLRWLSDGNR 920
+ LPVKW+A E + D +++ QSDVWSYGI+LWE+FSL PYP I + + + DG +
Sbjct: 815 ARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQ 874
Query: 921 LEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNR-YVDL 971
+ +P FA +Y++M CW +PT RP+F ++ L +++ R R Y +L
Sbjct: 875 MAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNL 926
Score = 48.4 bits (110), Expect = 0.001
Identities = 52/234 (22%), Positives = 93/234 (39%), Gaps = 20/234 (8%)
Query: 150 YQNITIRNATK---KHNGVYTCLLTNTCGEEKDEFRKIFLEKPFLSLRDLAKGKLMGNAN 206
YQ + N + +H G Y+C+ +N G+ +E +L+L
Sbjct: 257 YQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVG 316
Query: 207 KSINIVIEIEAYPPVER---THFLKNDKYLPSNDLKYNVTT--LANGDPKLRINDLKLTD 261
+ +N+ + +EAYP ++ T+ + P L N TT L + LK ++
Sbjct: 317 EGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLA-NATTKDTYRHTFTLSLPRLKPSE 375
Query: 262 IANYTLVAENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRLENSEMNFACKVTGYPLPDVT 321
Y+ +A N + T +L + PE ++ I N C +GYP P+VT
Sbjct: 376 AGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFI-----NGSGTLLCAASGYPQPNVT 430
Query: 322 WIFSN------DEEHELSSTKSEQESLYAKTDYLKISVQASGVITCNAHNSKGE 369
W+ + DE L + ++ + K++VQ+ + HN E
Sbjct: 431 WLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYE 484
>UniRef50_Q8UVR8 Cluster: Macrophage colony-stimulating factor 1
receptor 2 precursor; n=2; Takifugu rubripes|Rep:
Macrophage colony-stimulating factor 1 receptor 2
precursor - Fugu rubripes (Japanese pufferfish)
(Takifugu rubripes)
Length = 1019
Score = 262 bits (643), Expect = 3e-68
Identities = 167/518 (32%), Positives = 262/518 (50%), Gaps = 45/518 (8%)
Query: 454 LHCEAEGVPRPTIYWYKDDELISNNSGYKLF----VDIVNHTIVNSTFEIENMQEKDNG- 508
L C + G P PTI WY ++ D + + ++ N+ G
Sbjct: 488 LTCSSSGYPVPTIAWYSCPGILKTCGNLTTTESSEADPTSEHDEENVRKLLNLPLSTGGD 547
Query: 509 -IYECVALNNASELRRAYTLVLKAEKSYTPYXXXXXXXXXXXXGMVAYLFTWKLKKQREL 567
EC+A N R+ + L + ++ + W+ K + E+
Sbjct: 548 VTAECIASNQVGAFRKVFHLREHNSAFMSALIGAGSTAAILFLLLLVVFYKWRQKPKYEI 607
Query: 568 TKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAE 627
+ ++ GN +F +D LLPY+ K+EFPR+KL G LG+GAFG V +A
Sbjct: 608 -RWKIIESTEGNHYTF-----VDPT--LLPYNYKWEFPRDKLRLGAVLGSGAFGKVVEAT 659
Query: 628 ARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKR 687
A G+ +VT VAVKM+K A + +AL SELKI+ HLG H NIVNLLGACT+
Sbjct: 660 AYGLGTDDVTR-VAVKMLKPRALSEEREALMSELKILSHLGYHDNIVNLLGACTQ---GG 715
Query: 688 ELIVIVEYCKYGNIHNYMQKHREVFIDQLTDNAEKNLGKINKGFLNSVGTTGTHSDYFSS 747
+++I EYC YG++ N+++ + F+ + E K G + S
Sbjct: 716 PMLMITEYCSYGDLLNFLRARAQDFMASILSADEMEGDPFYKNMATLYGRLRSDSGISCC 775
Query: 748 GNTKDTDHSLLYSGNSKRSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAF 807
+ ++ L G++++ + V G + GD + HQ
Sbjct: 776 SDYQEMQPIL---GSAEKQ-QGVQMGGLS-------FGDLLSFSHQ-------------- 810
Query: 808 QIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVK 867
+A+G+++L+ R +H D+AARNVLL D V KICDFGLAR + N++ Y + N+ LPVK
Sbjct: 811 -VAQGLDFLSTRNCIHRDVAARNVLLTDHRVAKICDFGLARDIQNDDSYIVQGNARLPVK 869
Query: 868 WLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS-PTDLLRWLSDGNRLEKPPF 926
W+A E + +++ QSDVWSYG++LWE+FSL K+PYPN++ T + + DG + +P F
Sbjct: 870 WMAPESIFQCVYTVQSDVWSYGVLLWEIFSLGKSPYPNVAVDTHFYKMIKDGRHMTQPDF 929
Query: 927 ADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
A +Y +M CW +PT RP+F + +++ L+ N+
Sbjct: 930 APVEMYQLMTHCWSLEPTDRPTFKMICQLIDRLLQSND 967
Score = 42.7 bits (96), Expect = 0.056
Identities = 38/171 (22%), Positives = 65/171 (38%), Gaps = 26/171 (15%)
Query: 216 EAYPPVERTHFLKNDKYLPSNDL-----KYNVTTLANGDPKLRINDLKLTDIANYTLVAE 270
E+YPP+ + K K +N++ Y++ + L + ++ D +YT
Sbjct: 401 ESYPPLSNQSWTKPTKVNNNNNVTMYQENYSIND-TRSEASLLLRRVRQEDHGSYTFHFS 459
Query: 271 NKYLTKNYTVDLRVFTKPEAKLLNNRIIKRLENSEMNFACKVTGYPLPDVTWI------- 323
N + + + +DLR++ P A II +N+ C +GYP+P + W
Sbjct: 460 NSFFSGSQNIDLRIYRSPSA------IISVEKNT---LTCSSSGYPVPTIAWYSCPGILK 510
Query: 324 ----FSNDEEHELSSTKSEQESLYAKTDYLKISVQASGVITCNAHNSKGEY 370
+ E E T E K L +S C A N G +
Sbjct: 511 TCGNLTTTESSEADPTSEHDEENVRKLLNLPLSTGGDVTAECIASNQVGAF 561
>UniRef50_Q1HTP2 Cluster: Tyrosine-protein kinase receptor; n=4;
Percomorpha|Rep: Tyrosine-protein kinase receptor -
Haplochromis burtoni (Burton's mouthbrooder)
Length = 1024
Score = 258 bits (632), Expect = 6e-67
Identities = 138/378 (36%), Positives = 222/378 (58%), Gaps = 29/378 (7%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIK 655
LPY +E R+ + G+ LG+GAFG V +A G+IN+ +T AVKMVK +D ++
Sbjct: 566 LPYSPTWEIDRDHVVLGQVLGSGAFGRVVEATISGLINSH-STKAAVKMVKPRSDA--VQ 622
Query: 656 ALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQ 715
+L SELK++VHLG H+N+VNLLGACT+ + +I E+C +G++ NY+Q+++ F+
Sbjct: 623 SLMSELKVLVHLGPHLNVVNLLGACTRG---GPVYLITEFCCHGDLVNYLQRNKHTFLH- 678
Query: 716 LTDNAEKNLGKINKGFLNSVGTTGTHSDYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYI 775
G T T SD + + S Y + S +
Sbjct: 679 --------------------GDTQTKSDNDGGYIDMNKEESAQYVAMKELSYADIEPAVY 718
Query: 776 QQEWQTKYEGDYIYECHQPRPLTS-GHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLA 834
+ + + + PL S L+ +++QI + M++L++RK +H DLAARN+L+
Sbjct: 719 ETPYTPADQQEASSLLLSDSPLLSLNDLISFSYQIVQAMDFLSSRKCVHRDLAARNILVC 778
Query: 835 DDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWE 894
+ +VK+CDFGLAR + +++Y + NS LP+KW++ E + I+S+QSDVWSYG++LWE
Sbjct: 779 EGKLVKVCDFGLARDLLKDQDYIARGNSFLPLKWMSPESIFQNIYSSQSDVWSYGVLLWE 838
Query: 895 MFSLAKTPYPNISPT-DLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQ 953
+FSL +PYP++ T + L G R+ +P A + +Y+VM RCW +KP +RPSF+ L
Sbjct: 839 IFSLGCSPYPDLPMTQEFYSALKRGYRMSRPDHAPEDMYDVMKRCWEEKPQSRPSFSSLL 898
Query: 954 EILGNFLEDNERNRYVDL 971
+GN + D+ + RY+ +
Sbjct: 899 ITMGNMVTDDYKQRYLQI 916
Score = 48.8 bits (111), Expect = 9e-04
Identities = 67/324 (20%), Positives = 125/324 (38%), Gaps = 29/324 (8%)
Query: 5 VVPRDCSKIVIECRPTTPDVNVTLSSEIPDYYYPSFRYSPKIGFVPENSMPSDDQIISFV 64
VV ++ + I C + P++NV+L Y PS R + + P S+
Sbjct: 127 VVMKEGEEGTIPCMVSNPNLNVSL------YERPSRRLVSGMTYEPGRGFTGHLNDTSY- 179
Query: 65 LCEFVRG--ETRIEKYIYVSKHIKKPPKPKVAGGHKQFLEGETFTIHCRVPNDGLINFKW 122
+C G E + Y S + K + + +GE T++C V + ++ F W
Sbjct: 180 MCIATNGAEEKESQTYYVFSIIVPKVMEVDLTVSSSVLKQGEVLTVNCTVRDTEMVFFSW 239
Query: 123 KYPPEVTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEE--KDE 180
+P +E T+ + NIT AT +GVY+C + T +
Sbjct: 240 GFP---RRQEIE---PLTDFLPNQIRSFVNITA--ATVADSGVYSCTVQETTQGQTVMKN 291
Query: 181 FRKIFLEKPFLSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDKYLPSNDLKY 240
L++ ++ L L + + + ++ + ++I+A+ P + + ++ + +
Sbjct: 292 ITITVLDRGYVYLWPLGETNVSSLLHHTLELSVDIDAH-PAPTIIWTRQNQSVATETTTI 350
Query: 241 NVTTLANGD--PKLRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAKLLNNRII 298
N T L++ L + +++ +YT N + T +L V P RI
Sbjct: 351 NTTHLSDSRYVSTLTLVRVQMDQTGSYTATISNDDDIREVTFNLEVQAPP-------RIT 403
Query: 299 KRLENSEMNFACKVTGYPLPDVTW 322
E C G P P VTW
Sbjct: 404 SLSEVRSNAVLCVSEGAPPPSVTW 427
>UniRef50_Q9I8N6 Cluster: Macrophage colony-stimulating factor 1
receptor precursor; n=23; Clupeocephala|Rep: Macrophage
colony-stimulating factor 1 receptor precursor - Danio
rerio (Zebrafish) (Brachydanio rerio)
Length = 977
Score = 258 bits (632), Expect = 6e-67
Identities = 159/430 (36%), Positives = 238/430 (55%), Gaps = 42/430 (9%)
Query: 552 MVAYLFTWKLKKQRELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTF 611
++ ++ +K K + E+ + ++ +GN +F ID LPY+EK+EFPR+KL
Sbjct: 535 LIFMIYKYKQKPRYEI-RWKIIEATNGNNYTF-----IDPTQ--LPYNEKWEFPRDKLKL 586
Query: 612 GKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHV 671
GK LGAGAFG V +A A G+ + T VAVKM+K +A +AL SELKI+ HLG+H
Sbjct: 587 GKTLGAGAFGKVVEATAYGLGKEDNITRVAVKMLKASAHPDEREALMSELKILSHLGQHK 646
Query: 672 NIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDNAEKNLGKINKGF 731
NIVNLLGACT ++VI EYC +G++ N+++ E F
Sbjct: 647 NIVNLLGACTHG---GPVLVITEYCCHGDLLNFLRSKAE-------------------NF 684
Query: 732 LNSVGTTGTHSDYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQEWQTKYEG----DY 787
LN V T + + T+ + S + S S+ Y+ T D
Sbjct: 685 LNFVMTIPNFPEPMTDYKNVSTERMFVRSDSGISS--TCSDHYLDMRPVTSRPTNSALDS 742
Query: 788 IYECHQPR-PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGL 846
EC + PL LL ++ Q+A+G+++LA + +H D+AARNVLL + V KICDFGL
Sbjct: 743 SSECQEDSWPLDMDDLLRFSSQVAQGLDFLAAKNCIHRDVAARNVLLTNSRVAKICDFGL 802
Query: 847 ARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNI 906
AR + N+ Y K N+ LPVKW+A E + + +++ QSDVWSYGI+LWE+FSL K+PYPNI
Sbjct: 803 ARDIMNDSNYVVKGNARLPVKWMAPESIFECVYTVQSDVWSYGIMLWEIFSLGKSPYPNI 862
Query: 907 -SPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTE----LQEILGNFLE 961
+ + + G ++ +P FA +Y +M CW+ RP+F++ +Q +LG E
Sbjct: 863 LVDSKFYKMIKCGYQMSRPDFAPPEMYTIMKMCWNLDAAERPTFSKISQMIQRMLGETSE 922
Query: 962 DNERNRYVDL 971
+ Y ++
Sbjct: 923 QQDTQEYKNI 932
Score = 74.9 bits (176), Expect = 1e-11
Identities = 79/370 (21%), Positives = 146/370 (39%), Gaps = 34/370 (9%)
Query: 6 VPRDCSKIVIECRPTTP---DVNVTLSSEIPDYYYPSFRYSPKIGFVPENSMPSDDQIIS 62
V ++ +++ C T P D + + Y + Y P+ G + N P +
Sbjct: 127 VRKEGEDLLLPCLLTDPEATDFTFRMDNGSAAPYGMNITYDPRKGVLIRNVHPGFNA--D 184
Query: 63 FVLCEFVRGETRIEKY--IYVSKHIKKPPKPKVAGGHKQFLEGETFTIHCRVPNDGLI-N 119
++ C + G ++ K I + + ++ PP + L GE I C N N
Sbjct: 185 YICCARIGGAEKVSKIFSINIIQRLRFPPYVYLKRNEYVKLVGERLQISCTTNNPNFYYN 244
Query: 120 FKWKYPPEVTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEKD 179
W + + + E S ++ + SI +TI + H G TC N G
Sbjct: 245 VTWTHSSRMLPKAEEKSTMEGDRLAIESI----LTIPSVQLSHTGNITCTGQNEAGANSS 300
Query: 180 EFRKIFLEKPFLSLRDLAKGKLMGNA-------NKSINIVIEIEAYPPVERTHF---LKN 229
+ + +E+P++ L KL +++ + IEAYPP+ + +
Sbjct: 301 TTQLLVVEEPYIRLSPKLSSKLTHRGLSIEVSEGDDVDLGVLIEAYPPLTSHKWETPTSH 360
Query: 230 DKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPE 289
+ LP N +N + L + L +I YTL +N + + T D++++TKP
Sbjct: 361 NASLPENRF-FNHND--RYEALLLLKRLNFEEIGQYTLNVKNSMKSASITFDIKMYTKPV 417
Query: 290 AKLLNNRIIKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYAKT-DY 348
A++ + EN +C+ GYP P + W ++ + + +T ++
Sbjct: 418 ARV-------KWEN-VTTLSCRSYGYPAPSILWYQCTGIRTTCPENTTDLQPIQTQTVEF 469
Query: 349 LKISVQASGV 358
K S A GV
Sbjct: 470 QKESFGAVGV 479
>UniRef50_UPI0000D8BE91 Cluster: UPI0000D8BE91 related cluster; n=2;
Danio rerio|Rep: UPI0000D8BE91 UniRef100 entry - Danio
rerio
Length = 797
Score = 254 bits (623), Expect = 8e-66
Identities = 144/375 (38%), Positives = 212/375 (56%), Gaps = 18/375 (4%)
Query: 598 YDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKAL 657
YD K+EFPRE L G +LG+GAFG+V +A A GI V+ VAVKM+K + +AL
Sbjct: 428 YDLKWEFPRENLELGNELGSGAFGMVVQATAYGISKPGVSVQVAVKMLKEKHQAVEKEAL 487
Query: 658 ASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLT 717
SELK++ H+G H NIVNLLGACT + +I +YC G++ NY++ +RE F LT
Sbjct: 488 MSELKMLTHIGHHENIVNLLGACT---GSGPVYLIFQYCCNGDLLNYLKSNRECFHKYLT 544
Query: 718 DNAEKNLGKINKGFLNSVGTTGTHSDYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQ 777
D K+ + G +S ++ ++ L S S S +EG + +
Sbjct: 545 DAFNKDRFR---------GLYHNFQQNRNSSKEQEKENDALLS--SSISSGSPAEGLLCE 593
Query: 778 EWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDN 837
E + E H LT LL ++FQ+A+GM++L+ + +H DLAARNVL+
Sbjct: 594 EMLECEDEHQEEELHS---LTYDDLLSFSFQVAKGMQFLSAKNCIHRDLAARNVLVTHGR 650
Query: 838 VVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFS 897
VKI DFGLAR + ++ Y + N LPVKW+A E + I++ +SD+W+YGI+LWE+FS
Sbjct: 651 QVKIADFGLARDIEHDSNYVVRGNVRLPVKWMAPESIFKGIYTMESDIWAYGILLWEIFS 710
Query: 898 LAKTPYPNISPTD-LLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEIL 956
L TPYP ++ + R + G LE+P +A + +Y VM RCW P RP F+++ +
Sbjct: 711 LGVTPYPGVTVNNTFYRMIESGYHLEQPYYAAESVYKVMCRCWALNPVDRPCFSKIVAFM 770
Query: 957 GNFLEDNERNRYVDL 971
L E Y ++
Sbjct: 771 EKELAALEERLYYNV 785
>UniRef50_Q4RKW0 Cluster: Tyrosine-protein kinase receptor; n=1;
Tetraodon nigroviridis|Rep: Tyrosine-protein kinase
receptor - Tetraodon nigroviridis (Green puffer)
Length = 1337
Score = 236 bits (577), Expect = 3e-60
Identities = 185/591 (31%), Positives = 285/591 (48%), Gaps = 67/591 (11%)
Query: 424 ILDDIELLAPIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKL 483
ILD + + A I+ D + G+S+ C G P P + W+ + S +
Sbjct: 573 ILDSVAVPAVIVDLLDIHHGSAT--GQSVV--CITRGQPTPLVEWFVCKNIKSCTNDTSS 628
Query: 484 FVDI-VNHTIV--NSTFEIENMQE--------KDNGIYECVALNNASELRRAYTLVLKA- 531
+V + VN T V +S F+ +N E + C+A N + + R LV
Sbjct: 629 WVPLPVNATEVTMDSRFDEDNNLETQVMFGHLESTLAVRCLARNEMAAVSREIKLVSTGP 688
Query: 532 EKSYTPYXXXXXXXXXXXXGMVAYLFTWKLKKQRELTKAGLLNFKSGNKKSFNPNLGIDE 591
T ++ + WK K + E+ + ++ S + + + +D
Sbjct: 689 HPELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEI-RWRVIESVSPDGHEY---IYVDP 744
Query: 592 QADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADN 651
LPYD ++EFPR++L G+ LG+GAFG V + A G+ ++ VAVKM+K TA +
Sbjct: 745 MQ--LPYDSRWEFPRDRLVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARS 802
Query: 652 MYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREV 711
+AL SELKIM HLG H+NIVNLLGACTK + +I EYC YG++ NY+ K+RE
Sbjct: 803 SEKQALMSELKIMTHLGPHLNIVNLLGACTK---SGPIYIITEYCFYGDLVNYLHKNREN 859
Query: 712 FID---QLTDNAEKNLGKINKGFLNS----VGTTGTHSDYFSSGNTKDTDH-SLLYSGNS 763
F++ + + E ++ IN +S + + + DY +T + +L N+
Sbjct: 860 FLNPKAEKNNKKELDIFGINPADESSRSYVILSFESKGDYMDMKQADNTQYVPMLERSNT 919
Query: 764 KRSGRKVSEGY---IQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRK 820
+ Y Q+ E D + + LT+ LL + +Q+A+GME+LA++
Sbjct: 920 SKYSDLQGSNYDHPPSQKGSNDGEMDELLSDNVNEGLTTKDLLSFTYQVAKGMEFLASKN 979
Query: 821 VLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAI----ECMVD 876
+H DLAARNVLL+ +VKICDFGLAR + ++ Y K + P AI + V
Sbjct: 980 CVHRDLAARNVLLSQGKIVKICDFGLARDIMHDNNYVSKGSVSCPWAHTAITVEQKATVS 1039
Query: 877 RIFSTQSDV--------W------------------SYGIVLWEMFSLAKTPYPN-ISPT 909
R +T S V W SYGI+LWE+FSL TPYP I +
Sbjct: 1040 RRMNTFSFVPQTFLPVKWMAPESIFDNLYTSLSDVWSYGILLWEIFSLGGTPYPGMIVDS 1099
Query: 910 DLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFL 960
+ G R+ KP A +Y++M+RCW+ +P RPSF L + + + L
Sbjct: 1100 SFYNKIKSGYRMSKPEHAPQDVYDMMMRCWNSEPEKRPSFLGLSDTVASLL 1150
>UniRef50_Q4S569 Cluster: Chromosome 6 SCAF14737, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 6
SCAF14737, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 441
Score = 221 bits (539), Expect = 1e-55
Identities = 155/422 (36%), Positives = 224/422 (53%), Gaps = 68/422 (16%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIK 655
L YD K+EFPRE L GK+LG+GAFG+V +A A GI V VAVKM+K ++ +
Sbjct: 32 LEYDTKWEFPRENLELGKELGSGAFGMVVQATAYGINKPGVPQQVAVKMLKEKHQSVEKE 91
Query: 656 ALASELKIMVHLGKHVNIVNLLGACTK-----------HI-----AKRELI--------- 690
AL SELK++ H+G H NIVNLLGACT+ H+ A + +I
Sbjct: 92 ALMSELKMLTHIGHHDNIVNLLGACTESGTATTPSHPGHLEAQDSAGKNVILNVFLQAGP 151
Query: 691 --VIVEYCKYGNIHNYMQKHREVFIDQLTDNAEKNLGKINKGFLNSVGTTGTHSDYFSSG 748
+I +YC YG++ NY++K+RE++ +TD K+ + + + N T T S
Sbjct: 152 TYLIFQYCCYGDLLNYLKKNRELYHKSVTDAFNKD--RFSSLYQNLETTPRT-----SEV 204
Query: 749 NTKDTDHSLLYSGNSKRSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQ 808
T ++H + +S S +S E + E D + LT LL +AFQ
Sbjct: 205 KTAASNHPTV--ADSPWSKLSLS---AHPEMAEELEDD---RPEALQTLTFDDLLSFAFQ 256
Query: 809 IARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN------- 861
+A+GME+L+++ +H DLAARN+L+ +VKI DFGLAR + ++ Y + N
Sbjct: 257 VAKGMEFLSSKNCIHRDLAARNILVTKARLVKIGDFGLARDVEHDSNYVVRGNVCASIGR 316
Query: 862 ----------SP--------LPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
SP LPVKW+A E I++ +SDVW+YGI+LWE+FSL TPY
Sbjct: 317 ARFVCWRTFWSPVASLRQVRLPVKWMAPESTFQGIYTMKSDVWAYGILLWEIFSLGVTPY 376
Query: 904 PNIS-PTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLED 962
P I + + G ++E P +A D +Y M RCW P +RP F+EL + + L D
Sbjct: 377 PGIKVDHNFYSMIERGFKMECPYYASDAVYQTMCRCWALDPGSRPPFSELVSFMCHQLTD 436
Query: 963 NE 964
E
Sbjct: 437 RE 438
>UniRef50_UPI00015B54DC Cluster: PREDICTED: similar to vascular
endothelial growth factor receptor 2; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to vascular
endothelial growth factor receptor 2 - Nasonia
vitripennis
Length = 1005
Score = 219 bits (535), Expect = 4e-55
Identities = 98/183 (53%), Positives = 136/183 (74%), Gaps = 1/183 (0%)
Query: 790 ECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARS 849
E + L + LL WAFQ+ARGMEYL+ + VLHGDLAARN+LL +NVVKICDFGLA+
Sbjct: 795 ESSRKESLCTQDLLSWAFQVARGMEYLSQKNVLHGDLAARNILLTHNNVVKICDFGLAKV 854
Query: 850 MYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPT 909
M ++ Y K+ LP+KW+AIE + DR+FS SDVWS+GIVLWE F+LA+ PY +I P
Sbjct: 855 M-EDDSYMKRSRGLLPIKWMAIESIRDRVFSVHSDVWSFGIVLWEFFTLAQVPYCDILPE 913
Query: 910 DLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYV 969
L+ L G+RLEKP +A+ +Y++M+ CW+++PT RP+FT L E +G+ L+DN ++ Y+
Sbjct: 914 VQLQKLLKGHRLEKPKYANGEIYSIMVPCWNEEPTLRPTFTMLVEQIGDLLQDNVKSYYM 973
Query: 970 DLN 972
DL+
Sbjct: 974 DLS 976
Score = 172 bits (418), Expect = 5e-41
Identities = 118/337 (35%), Positives = 182/337 (54%), Gaps = 35/337 (10%)
Query: 454 LHCEAEGVPRPTIYWYKD------DE---LISNNS----------GYKLFVD---IVNHT 491
L C A+G P+P + WY+D DE ++S Y+ F+D + N+
Sbjct: 476 LKCGAKGRPKPVVTWYQDGVQLQKDEDSSIVSKKELDLPVQEREEHYQQFIDQEYLPNND 535
Query: 492 IVNSTFEIENMQEKDNGIYECVALNNASELR--RAYTLVLKAEKSYTPYXXXXXXXXXXX 549
I+ + K + Y CVA N +++ + +++ K + ++
Sbjct: 536 NNPQILSIKYLVLKVSTNYTCVAKNKFGQVKAYQIFSIPGKNDWAHPAIAFFIVIVAIVI 595
Query: 550 XGMVAYLFTWKLKKQRELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKL 609
+ ++R + +AGLL F++ + +P I +Q DLL YD+K+EF RE+L
Sbjct: 596 CNFGFIKIRSRTVRRRCMREAGLLYFQNITDEELSPITMIYDQVDLLRYDKKWEFTRERL 655
Query: 610 TFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGK 669
K+LG+GAFG+V KA+A GI E T VAVKMV++ A+ ++ALASELKIM++LG+
Sbjct: 656 KLEKKLGSGAFGIVIKAKAYGISPHEAVTTVAVKMVRQYAETFQVRALASELKIMIYLGR 715
Query: 670 HVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDNAEKNLGKINK 729
H+NIVNLLGACT IA EL+VIVEYC YGN+H+Y+ HR+ FIDQ +K G I+
Sbjct: 716 HLNIVNLLGACT--IA-GELLVIVEYCPYGNLHDYLLTHRKQFIDQ----RDKKTGTID- 767
Query: 730 GFLNSVGTTGTHSDYFSSGNTKDTDHSLLYSGNSKRS 766
S+G T + S + + ++ + + K S
Sbjct: 768 ---FSIGQVATFDECVSCLSVESSEETRNIESSRKES 801
>UniRef50_Q16RK6 Cluster: Receptor protein tyrosine kinase; n=1;
Aedes aegypti|Rep: Receptor protein tyrosine kinase -
Aedes aegypti (Yellowfever mosquito)
Length = 817
Score = 214 bits (523), Expect = 1e-53
Identities = 128/376 (34%), Positives = 209/376 (55%), Gaps = 37/376 (9%)
Query: 595 LLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEV--TTPVAVKMVKRTADNM 652
++P ++ E E++ LG GAFG V K G++ V + VAVKM+K
Sbjct: 453 IVPINDGMEVGLEQIQLMDVLGEGAFGFVRK----GLLTTAVGESRDVAVKMLKECPSLA 508
Query: 653 YIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ------ 706
IKA E+++M +G H N+V ++G T+++ K ++++ EYC GN+ N+++
Sbjct: 509 DIKAFRREIEVMKSVGCHPNVVCIVGQYTRNVTK--MMLLTEYCSGGNLLNFLRSVWNSV 566
Query: 707 -KHREVFIDQLTDNAEKNLGKINKGFLNSVGTTGTHSDYFSSGNTKDTDHSLLYSGNSKR 765
KHR +F D+ + N + + G+ + + + DTD ++ +
Sbjct: 567 LKHRSLFGG--CDSIDVNKTRCSSGYESPINSCEI-----------DTDLPVMVENKLYQ 613
Query: 766 SGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGD 825
R+VS + Q Y G+ + +P++S L+ +A QIA GME+LA +V+H D
Sbjct: 614 HQRRVSNEFDNQ----CYFGE-----EEKQPISSKQLIEFARQIAYGMEFLARNRVVHRD 664
Query: 826 LAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDV 885
LAARN+L++D VKI DFGL+R +Y Y+K N LP+KWLA+E + +++++QSDV
Sbjct: 665 LAARNILVSDGATVKISDFGLSRDIYQENMYRKTTNGKLPIKWLALESLTHQVYTSQSDV 724
Query: 886 WSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTA 945
WS+GIVL+E+ +L PYP + +LL L G R+E+P + LY +ML CW P+
Sbjct: 725 WSFGIVLYEICTLGGNPYPMLETGNLLLELKAGYRMERPASCCEELYELMLSCWRALPSE 784
Query: 946 RPSFTELQEILGNFLE 961
RP+F+ + L +E
Sbjct: 785 RPTFSTVTNQLEKMIE 800
>UniRef50_Q9U8U9 Cluster: PDGFR-like; n=1; Eptatretus burgeri|Rep:
PDGFR-like - Eptatretus burgeri (Inshore hagfish)
Length = 401
Score = 212 bits (517), Expect = 5e-53
Identities = 116/322 (36%), Positives = 182/322 (56%), Gaps = 25/322 (7%)
Query: 640 VAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYG 699
VAVKM++ TA +AL SELKIM HLG H+NIVNL+GACT + ++ EYC +G
Sbjct: 18 VAVKMLQPTARTCEKQALMSELKIMTHLGAHLNIVNLIGACT---LGGPVYIVTEYCCHG 74
Query: 700 NIHNYMQKHREVFIDQLTDNAEKNLGKINKGFLNSVGTTGTHSDYFSSGNTKDTDHSLLY 759
++ Y+ +++ + +++ D A + ++Y + + +
Sbjct: 75 DLVGYLHRYKHLVLNESRDTA-----------------SSCPTNYMEMNEQNGSQYITMA 117
Query: 760 SGNSKRSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANR 819
S + Y+ + D + C PL+ L +++Q ARGME+LA+
Sbjct: 118 SSPGHMIYADLEGSYLSSLSSPENIEDQMPVC----PLSLLDLRYFSYQAARGMEFLASH 173
Query: 820 KVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIF 879
+H DLAARNVLL ++ +VKICDFGLAR + + Y K + LPVKW+A E + ++
Sbjct: 174 NCVHRDLAARNVLLGNERMVKICDFGLARDLSIDANYISKGTTFLPVKWMAPESIFHSLY 233
Query: 880 STQSDVWSYGIVLWEMFSLAKTPYPNIS-PTDLLRWLSDGNRLEKPPFADDRLYNVMLRC 938
+ QSDVWSYG++LWE+F+L ++PYP ++ ++ L +G R+EKP + D +Y +M +C
Sbjct: 234 TPQSDVWSYGVLLWEIFTLGESPYPGMTVDSNFYTRLREGYRMEKPKLSSDNIYQLMGKC 293
Query: 939 WHQKPTARPSFTELQEILGNFL 960
W+ RP+FTEL E +G L
Sbjct: 294 WNSNADKRPTFTELAEKIGQTL 315
>UniRef50_P11362 Cluster: Basic fibroblast growth factor receptor 1
precursor; n=310; Euteleostomi|Rep: Basic fibroblast
growth factor receptor 1 precursor - Homo sapiens (Human)
Length = 822
Score = 198 bits (483), Expect = 7e-49
Identities = 92/222 (41%), Positives = 142/222 (63%), Gaps = 5/222 (2%)
Query: 786 DYIYE-CHQPRP-LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y H P L+S L+ A+Q+ARGMEYLA++K +H DLAARNVL+ +DNV+KI D
Sbjct: 582 EYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIAD 641
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR +++ + Y+K N LPVKW+A E + DRI++ QSDVWS+G++LWE+F+L +PY
Sbjct: 642 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 701
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P + +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L +
Sbjct: 702 PGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALT 761
Query: 964 ERNRYVDLNAPYNEMNAELMTGEDYLAMVCAPDYNNIVTPSP 1005
Y+DL+ P ++ + D + C+ +++ + P
Sbjct: 762 SNQEYLDLSMPLDQYSPSF---PDTRSSTCSSGEDSVFSHEP 800
Score = 97.5 bits (232), Expect = 2e-18
Identities = 54/116 (46%), Positives = 70/116 (60%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVT--TPVAVKMVKRTADNMY 653
LP D ++E PR++L GK LG G FG V AEA G+ + T VAVKM+K A
Sbjct: 465 LPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD 524
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y+Q R
Sbjct: 525 LSDLISEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLQARR 577
Score = 36.3 bits (80), Expect = 4.9
Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 4/68 (5%)
Query: 260 TDIANYTLVAENKYLTKNYTVDLRVFTK-PEAKLLNNRIIKRLE---NSEMNFACKVTGY 315
+D NYT + EN+Y + N+T L V + P +L + S + F CKV
Sbjct: 223 SDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 282
Query: 316 PLPDVTWI 323
P P + W+
Sbjct: 283 PQPHIQWL 290
>UniRef50_P22182 Cluster: Fibroblast growth factor receptor 1
precursor; n=33; Euteleostomi|Rep: Fibroblast growth
factor receptor 1 precursor - Xenopus laevis (African
clawed frog)
Length = 812
Score = 197 bits (481), Expect = 1e-48
Identities = 87/194 (44%), Positives = 132/194 (68%), Gaps = 2/194 (1%)
Query: 786 DYIYE--CHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y C + L+ L+ A+Q+ARGM+YLA++K +H DLAARNVL+ +DN++KI D
Sbjct: 576 EYCYNPTCVPDQLLSFKDLVSCAYQVARGMDYLASKKCIHRDLAARNVLVTEDNIMKIAD 635
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR +++ + Y+K N LPVKW+A E + DRI++ QSDVWS+G++LWE+F+L +PY
Sbjct: 636 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 695
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P + +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L L +
Sbjct: 696 PGVPMEELFKLLKEGHRMDKPTNCTNELYMMMKDCWHAMPSQRPTFNQLVEDLDRILALS 755
Query: 964 ERNRYVDLNAPYNE 977
Y+DL+ P N+
Sbjct: 756 SNQEYLDLSMPVNQ 769
Score = 92.7 bits (220), Expect = 5e-17
Identities = 52/116 (44%), Positives = 69/116 (59%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVT--TPVAVKMVKRTADNMY 653
LP D ++E R++L GK LG G FG V AEA G+ + T VAVKM+K A
Sbjct: 459 LPEDPRWEVARDRLILGKPLGEGCFGQVVMAEAIGLDKEKPNKVTKVAVKMLKSDASEKD 518
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y++ R
Sbjct: 519 LSDLISEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYTSKGNLREYLRARR 571
Score = 37.5 bits (83), Expect = 2.1
Identities = 20/90 (22%), Positives = 39/90 (43%), Gaps = 8/90 (8%)
Query: 450 RSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDN 507
++++ C A G P PT+ W K NN ++ I + + + T+ + +++ D
Sbjct: 168 KTVKFRCPANGTPTPTLRWLK------NNRAFQQDQRIGGYKVRSQTWSLIMDSVVPSDK 221
Query: 508 GIYECVALNNASELRRAYTLVLKAEKSYTP 537
G Y C+ N + Y L + + P
Sbjct: 222 GNYTCIVENKYGAINHTYQLDVVERSPHRP 251
Score = 37.5 bits (83), Expect = 2.1
Identities = 27/108 (25%), Positives = 46/108 (42%), Gaps = 5/108 (4%)
Query: 220 PVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYT 279
P +LKN++ D + + + L ++ + +D NYT + ENKY N+T
Sbjct: 180 PTPTLRWLKNNRAF-QQDQRIGGYKVRSQTWSLIMDSVVPSDKGNYTCIVENKYGAINHT 238
Query: 280 VDLRVFTK-PEAKLLNNRIIKRLE---NSEMNFACKVTGYPLPDVTWI 323
L V + P +L + + F+CKV P P + W+
Sbjct: 239 YQLDVVERSPHRPILQAGLPANTSVTVGTTAEFSCKVYSDPQPHIQWL 286
Score = 35.5 bits (78), Expect = 8.5
Identities = 22/79 (27%), Positives = 34/79 (43%), Gaps = 6/79 (7%)
Query: 103 GETFTIHCRVPNDGLINFKWKYPPEVTNDSVE------VSVVKTEATTTGSIVYQNITIR 156
G T C+V +D + +W E+ V V ++KT T + + +R
Sbjct: 266 GTTAEFSCKVYSDPQPHIQWLRHIEINGSRVASDGFPYVEILKTAGVNTSDKDMEVLHLR 325
Query: 157 NATKKHNGVYTCLLTNTCG 175
N T + G YTCL N+ G
Sbjct: 326 NVTFEDAGQYTCLAANSIG 344
>UniRef50_Q3TJ05 Cluster: 14 days pregnant adult female placenta cDNA,
RIKEN full-length enriched library, clone:I530025O09
product:fibroblast growth factor receptor 1, full insert
sequence; n=18; Eumetazoa|Rep: 14 days pregnant adult
female placenta cDNA, RIKEN full-length enriched library,
clone:I530025O09 product:fibroblast growth factor
receptor 1, full insert sequence - Mus musculus (Mouse)
Length = 386
Score = 196 bits (479), Expect = 2e-48
Identities = 91/222 (40%), Positives = 141/222 (63%), Gaps = 5/222 (2%)
Query: 786 DYIYE-CHQPRP-LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y H P L+S L+ A+Q+ARGMEYLA++K +H DLAARN L+ +DNV+KI D
Sbjct: 146 EYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNALVTEDNVMKIAD 205
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR +++ + Y+K N LPVKW+A E + DRI++ QSDVWS+G++LWE+F+L +PY
Sbjct: 206 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 265
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P + +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L +
Sbjct: 266 PGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALT 325
Query: 964 ERNRYVDLNAPYNEMNAELMTGEDYLAMVCAPDYNNIVTPSP 1005
Y+DL+ P ++ + D + C+ +++ + P
Sbjct: 326 SNQEYLDLSIPLDQYSPSF---PDTRSSTCSSGEDSVFSHEP 364
Score = 97.5 bits (232), Expect = 2e-18
Identities = 54/116 (46%), Positives = 70/116 (60%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVT--TPVAVKMVKRTADNMY 653
LP D ++E PR++L GK LG G FG V AEA G+ + T VAVKM+K A
Sbjct: 29 LPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD 88
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y+Q R
Sbjct: 89 LSDLISEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLQARR 141
>UniRef50_UPI0000D55449 Cluster: PREDICTED: similar to CG7223-PA,
isoform A; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG7223-PA, isoform A - Tribolium castaneum
Length = 861
Score = 194 bits (473), Expect = 1e-47
Identities = 91/193 (47%), Positives = 128/193 (66%), Gaps = 1/193 (0%)
Query: 783 YEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKIC 842
YE E + + LT L+ +A+Q+ARGMEYLA+R+ +H DLAARNVL++DD +KI
Sbjct: 635 YEPAIGLEEKEKKTLTQKDLVSFAYQVARGMEYLASRRCIHRDLAARNVLVSDDYFLKIA 694
Query: 843 DFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTP 902
DFGLAR ++ N+ Y+K + LPVKW+A E + R+++TQSDVWSYGI+LWE+ +L TP
Sbjct: 695 DFGLARDIHCNDYYRKTTDGRLPVKWMAPEALFHRVYTTQSDVWSYGILLWEIMTLGGTP 754
Query: 903 YPNI-SPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
YP++ S L + L +G+R+EKPP +Y +M CW KP RP+F++L E L L
Sbjct: 755 YPSVPSVEKLFQLLRNGHRMEKPPCCSLEIYMLMRECWSYKPNERPTFSQLVEDLDRILT 814
Query: 962 DNERNRYVDLNAP 974
Y+DL P
Sbjct: 815 ITANEEYLDLGLP 827
Score = 105 bits (252), Expect = 7e-21
Identities = 58/135 (42%), Positives = 82/135 (60%), Gaps = 4/135 (2%)
Query: 576 KSGNKKSFNPNLGIDEQADL-LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINA 634
K +KS N N G ++ LP D +E PR L GK LG GAFG V KAEA G++
Sbjct: 499 KIEKQKSQNNNSGDGMISEYELPMDSDWEIPRSMLCLGKSLGEGAFGKVVKAEAVGLLKP 558
Query: 635 EVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVE 694
++ VAVKM+K + + L SE+++M +GKH NI+NLLG CT+ L V+VE
Sbjct: 559 GASSIVAVKMLKEGHTDNEMMDLVSEMEMMKMIGKHNNIINLLGCCTQ---GGPLYVVVE 615
Query: 695 YCKYGNIHNYMQKHR 709
Y YGN+ +++++HR
Sbjct: 616 YAPYGNLRDFLRQHR 630
Score = 57.6 bits (133), Expect = 2e-06
Identities = 27/83 (32%), Positives = 47/83 (56%), Gaps = 8/83 (9%)
Query: 448 EGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDN 507
+G+S L C A+G P+P I WYK LI+ ++ + +++ +I N+Q +DN
Sbjct: 49 QGQSSILKCGAKGTPKPQISWYKGTNLITQSNK--------KYHLIHQNLKILNLQSEDN 100
Query: 508 GIYECVALNNASELRRAYTLVLK 530
G+Y+C+ N S + Y LV++
Sbjct: 101 GLYKCLVCNEVSCIHHNYNLVVE 123
Score = 38.7 bits (86), Expect = 0.91
Identities = 26/90 (28%), Positives = 38/90 (42%), Gaps = 8/90 (8%)
Query: 449 GRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNG 508
G + L C+A G P P I WYKDD+ + G DI + + +E++ D G
Sbjct: 239 GNMVNLKCKAGGNPTPNITWYKDDKPPNRQLG-----DI---RYQHWSLTLEDLVTGDTG 290
Query: 509 IYECVALNNASELRRAYTLVLKAEKSYTPY 538
Y CV N + Y + + PY
Sbjct: 291 DYTCVVCNELGCINFTYRVDVIERFPSKPY 320
>UniRef50_P35916 Cluster: Vascular endothelial growth factor receptor
3 precursor; n=42; Euteleostomi|Rep: Vascular endothelial
growth factor receptor 3 precursor - Homo sapiens (Human)
Length = 1298
Score = 193 bits (471), Expect = 2e-47
Identities = 84/167 (50%), Positives = 123/167 (73%), Gaps = 1/167 (0%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
PLT L+ ++FQ+ARGME+LA+RK +H DLAARN+LL++ +VVKICDFGLAR +Y + +
Sbjct: 1008 PLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPD 1067
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS-PTDLLRW 914
Y +K ++ LP+KW+A E + D++++TQSDVWS+G++LWE+FSL +PYP + + +
Sbjct: 1068 YVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQR 1127
Query: 915 LSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
L DG R+ P A + +ML CW P ARP+F+EL EILG+ L+
Sbjct: 1128 LRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQ 1174
Score = 149 bits (360), Expect = 6e-34
Identities = 93/267 (34%), Positives = 143/267 (53%), Gaps = 19/267 (7%)
Query: 451 SIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIY 510
S+++ C G P+I WYKD+ L+ SG VD+ + N I+ ++E+D G Y
Sbjct: 694 SLEMQCLVAGAHAPSIVWYKDERLLEEKSG----VDLADS---NQKLSIQRVREEDAGRY 746
Query: 511 ECVALNNASELRRAYTLVLKAEKSYTPYXXXXXXXXXXXXGMVAYLFTWKLKKQR--ELT 568
C N + + ++ ++ + G++A F W L +
Sbjct: 747 LCSVCNAKGCVNSSASVAVEGSED----KGSMEIVILVGTGVIAVFF-WVLLLLIFCNMR 801
Query: 569 KAGLLNFKSGNKKSF-NPN-LGIDEQADLLPYD-EKFEFPREKLTFGKQLGAGAFGVVYK 625
+ + K+G +P + ++EQ + L YD ++EFPRE+L G+ LG GAFG V +
Sbjct: 802 RPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVE 861
Query: 626 AEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIA 685
A A GI VAVKM+K A +AL SELKI++H+G H+N+VNLLGACTK
Sbjct: 862 ASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTK--P 919
Query: 686 KRELIVIVEYCKYGNIHNYMQKHREVF 712
+ L+VIVE+CKYGN+ N+++ R+ F
Sbjct: 920 QGPLMVIVEFCKYGNLSNFLRAKRDAF 946
Score = 52.8 bits (121), Expect = 5e-05
Identities = 92/402 (22%), Positives = 158/402 (39%), Gaps = 41/402 (10%)
Query: 99 QFLEGETFTIHCRVP---NDGLINFKWKYPPEVTNDSVEVSVVKTEATTTGSIVYQNITI 155
+ L GE ++C V N G + F W YP + V +++ T T + +TI
Sbjct: 241 ELLVGEKLVLNCTVWAEFNSG-VTFDWDYPGKQAERGKWVPERRSQQTHTE--LSSILTI 297
Query: 156 RNATKKHNGVYTCLLTNTCGEEKDEFRKIFLEKPFLSLRDLAKGKLMGNA-NKSINIVIE 214
N ++ G Y C N ++ I E PF+S+ L L A ++ + + ++
Sbjct: 298 HNVSQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLPVK 357
Query: 215 IEAYPPVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKY- 273
+ AYPP E + K+ K L + L + ++ YTL N
Sbjct: 358 LAAYPPPE-FQWYKDGKALSGR----------HSPHALVLKEVTEASTGTYTLALWNSAA 406
Query: 274 -LTKNYTVDLRVFTKP---EAKLLNNRIIKRLENSEMNFACKVTGYPLP-DVTWIFSNDE 328
L +N +++L V P E + + I R +S C G PLP + W +
Sbjct: 407 GLRRNISLELVVNVPPQIHEKEASSPSIYSR--HSRQALTCTAYGVPLPLSIQWHWRPWT 464
Query: 329 EHELSSTKSEQESLYAKTDYLKISVQASGVITCNAHNSKGEYFDSSTLLVYEINNGFGIL 388
++ + +S + + D + V T +A N E D+ T V N L
Sbjct: 465 PCKMFAQRSLRRR--QQQDLMPQCRDWRAVTTQDAVNPI-ESLDTWTEFVEGKNKTVSKL 521
Query: 389 QPLENWYSEKDSARKKCLASVYDYDNVSWLGSDGNILDDIELLAPIIREPDSNKDEEAME 448
++N SA KC+ S + +G D ++ P +S EE +E
Sbjct: 522 -VIQN---ANVSAMYKCVVS-------NKVGQDERLIYFYVTTIPDGFTIESKPSEELLE 570
Query: 449 GRSIQLHCEAEGVPRPTIYWYK-DDELISNNSGYKLFVDIVN 489
G+ + L C+A+ + WY+ + + + G L +D N
Sbjct: 571 GQPVLLSCQADSYKYEHLRWYRLNLSTLHDAHGNPLLLDCKN 612
>UniRef50_Q8IXC7 Cluster: Isoform of FGFR2; n=23; Euteleostomi|Rep:
Isoform of FGFR2 - Homo sapiens (Human)
Length = 709
Score = 190 bits (463), Expect = 2e-46
Identities = 85/194 (43%), Positives = 129/194 (66%), Gaps = 2/194 (1%)
Query: 786 DYIYECHQ--PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y+ ++ +T L+ +Q+ARGMEYLA++K +H DLAARNVL+ ++NV+KI D
Sbjct: 473 EYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIAD 532
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR + N + Y+K N LPVKW+A E + DR+++ QSDVWS+G+++WE+F+L +PY
Sbjct: 533 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 592
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P I +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L L
Sbjct: 593 PGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLT 652
Query: 964 ERNRYVDLNAPYNE 977
Y+DL+ P +
Sbjct: 653 TNEEYLDLSQPLEQ 666
Score = 102 bits (244), Expect = 7e-20
Identities = 57/116 (49%), Positives = 71/116 (61%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGI--INAEVTTPVAVKMVKRTADNMY 653
LP D K+EFPR+KLT GK LG G FG V AEA GI + VAVKM+K A
Sbjct: 356 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 415
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y++ R
Sbjct: 416 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLRARR 468
>UniRef50_Q8JG38 Cluster: Fibroblast growth factor receptor 2
precursor; n=11; Eumetazoa|Rep: Fibroblast growth factor
receptor 2 precursor - Danio rerio (Zebrafish)
(Brachydanio rerio)
Length = 817
Score = 190 bits (463), Expect = 2e-46
Identities = 85/182 (46%), Positives = 123/182 (67%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
PLT L+ +Q+ARGMEYLA++K +H DLAARNVL+ + NV+KI DFGLAR ++N +
Sbjct: 593 PLTFKDLVSCTYQVARGMEYLASQKCIHRDLAARNVLVTESNVMKIADFGLARDVHNIDY 652
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
Y+K N LPVKW+A E + DR+++ QSDVWS+G+++WE+F+L +PYP I +L + L
Sbjct: 653 YKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLL 712
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLNAPY 975
+G+R++KP + LY +M CWH + RP+F +L E L L Y+DL AP
Sbjct: 713 KEGHRMDKPANCTNELYMMMKDCWHAISSHRPTFKQLVEDLDRILTLATNEEYLDLCAPV 772
Query: 976 NE 977
+
Sbjct: 773 EQ 774
Score = 97.1 bits (231), Expect = 2e-18
Identities = 54/116 (46%), Positives = 70/116 (60%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIIN--AEVTTPVAVKMVKRTADNMY 653
LP D ++EF R+KLT GK LG G FG V AEA GI + VAVKM+K A
Sbjct: 464 LPEDPRWEFSRDKLTLGKPLGEGCFGQVVMAEALGIDKDKPKEAVTVAVKMLKDDATEKD 523
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +G+H NI+NLLGACT+ L VIVEY GN+ Y++ R
Sbjct: 524 LSDLVSEMEMMKMIGRHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLRARR 576
>UniRef50_Q1JUB8 Cluster: Fibroblast growth factor receptor; n=2;
Obtectomera|Rep: Fibroblast growth factor receptor -
Bombyx mori (Silk moth)
Length = 856
Score = 190 bits (462), Expect = 3e-46
Identities = 84/182 (46%), Positives = 123/182 (67%)
Query: 793 QPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYN 852
+ + LT L+ +++Q+ARGMEYLA+R+ +H D AARNVL++DD V+KI DFGLA+ +++
Sbjct: 651 EKKTLTQKDLVSFSYQVARGMEYLASRRCIHRDSAARNVLVSDDCVLKIADFGLAKDVHS 710
Query: 853 NEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLL 912
N+ Y+KK LPV+W+A E + ++F+TQ+DVWS+G++LWE+ +L TPYP + +
Sbjct: 711 NDYYRKKTEGRLPVRWMAPESLYHKVFTTQTDVWSFGVLLWEIMTLGGTPYPTVPGQYMY 770
Query: 913 RWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLN 972
+ LS G+R+EKPP +Y +M CW P RPSFTEL E L L Y+DL
Sbjct: 771 QHLSAGHRMEKPPCCSLEIYMLMRECWSFSPGDRPSFTELVEDLDKILTVTANQEYLDLG 830
Query: 973 AP 974
P
Sbjct: 831 LP 832
Score = 103 bits (248), Expect = 2e-20
Identities = 54/114 (47%), Positives = 72/114 (63%), Gaps = 3/114 (2%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIK 655
LP D +E PRE L+ GK LG G FG V KAE GI+ + + VAVKM+K + +
Sbjct: 527 LPMDIDWEVPRESLSLGKVLGEGEFGKVVKAECIGILKPGLQSVVAVKMLKEGHTDAEMM 586
Query: 656 ALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
AL SE+++M +GKHVNI+NLLG CT+ L VIVEY GN+ +++ HR
Sbjct: 587 ALVSEMEMMKMIGKHVNIINLLGCCTQ---DGPLYVIVEYAPNGNLREFLRNHR 637
Score = 41.1 bits (92), Expect = 0.17
Identities = 27/87 (31%), Positives = 40/87 (45%), Gaps = 9/87 (10%)
Query: 449 GRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNG 508
G S++ C AEG P P I WYK+ SN F +N ++ + + DNG
Sbjct: 224 GSSVRFKCPAEGNPTPNITWYKNK---SNPIQRTYFQPSYAKWAIN----LDELTKADNG 276
Query: 509 IYECVALNNASELRRAYTLVLKAEKSY 535
Y CV N + +T+VL ++ Y
Sbjct: 277 NYTCVVCNELGCIE--HTVVLHIQERY 301
>UniRef50_A7SI92 Cluster: Predicted protein; n=2; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 312
Score = 190 bits (462), Expect = 3e-46
Identities = 95/212 (44%), Positives = 135/212 (63%), Gaps = 5/212 (2%)
Query: 764 KRSGRKVS--EGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKV 821
KR G+ VS G Q + E D I + + ++SG L+ +A+Q+A+GMEYLA R
Sbjct: 104 KRRGKLVSLYTGDKPQSERGAAENDGIEDEEEDDGISSGDLMAFAWQVAQGMEYLARRGF 163
Query: 822 LHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFST 881
+H DLAARNVL+ D+ V K+ DFGL R MY + YQ K + LP+KW++IE + D+ F++
Sbjct: 164 VHRDLAARNVLVGDNKVAKVADFGLTRHMYE-DLYQGKTSRKLPLKWMSIEAIFDQAFTS 222
Query: 882 QSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQ 941
QSDVW+YG+ LWE+ +L TPYP I +LL+ L +G R+EKP +D LY +ML CW
Sbjct: 223 QSDVWAYGVFLWELVTLGGTPYPTIGNRELLKLLKEGYRMEKPDMCNDDLYTIMLSCWKD 282
Query: 942 KPTARPSFTELQEILGNFLEDNERNRYVDLNA 973
KP RP+F L+ L + + + N Y D +A
Sbjct: 283 KPEDRPTFENLRSTLEDLMMRD--NPYFDPSA 312
Score = 50.0 bits (114), Expect = 4e-04
Identities = 35/118 (29%), Positives = 56/118 (47%), Gaps = 6/118 (5%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+++E P EK+ +LG GAFG V+K + +A K ++R + + L
Sbjct: 3 DQWEVPYEKVLLDDELGEGAFGKVFKGTLVELPEQSSKYSIA-KSMRRKSTKPEERVLEG 61
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLT 717
G NIVN+LG CT + +IVEY YG++ +Y++K R + T
Sbjct: 62 N-SADERRGNR-NIVNMLGCCT---LTEPMFLIVEYLPYGDLLHYLRKRRGKLVSLYT 114
>UniRef50_A3EXK4 Cluster: Fibroblast growth factor receptor a; n=1;
Nematostella vectensis|Rep: Fibroblast growth factor
receptor a - Nematostella vectensis
Length = 441
Score = 190 bits (462), Expect = 3e-46
Identities = 84/182 (46%), Positives = 122/182 (67%)
Query: 792 HQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMY 851
H L + +AFQIARGMEYL+ +K +H DLAARN+L+ +D V+KI DFGLAR++
Sbjct: 230 HSQPSLIVRDFISFAFQIARGMEYLSFKKCIHRDLAARNILVGEDYVMKIADFGLARNVR 289
Query: 852 NNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDL 911
+ + Y+K + LP+KWLAIE + DR+++TQSDVW++GI+LWE+F+L +PYP I L
Sbjct: 290 DMDYYRKATDGRLPIKWLAIEALFDRVYTTQSDVWTFGILLWEIFTLGGSPYPGIPVEKL 349
Query: 912 LRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDL 971
L G R++ P D++Y++ML CW++ P ARPSFTEL+ L Y+++
Sbjct: 350 FELLKSGYRMQMPQKCPDKMYDIMLSCWNENPNARPSFTELRAEFDKMLTSMTDKEYLEI 409
Query: 972 NA 973
A
Sbjct: 410 LA 411
Score = 97.9 bits (233), Expect = 1e-18
Identities = 54/139 (38%), Positives = 82/139 (58%), Gaps = 7/139 (5%)
Query: 575 FKSGNKKSFNPNLGIDEQADL----LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARG 630
F SG + + I E++ L LP DE +E R ++T +QLG GAFG+V KAEA G
Sbjct: 81 FSSGVSSRLDSSSVITEESFLDFYELPIDEDWEIDRSQITIKEQLGEGAFGLVMKAEALG 140
Query: 631 IINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELI 690
+ + VAVKM+K A + L SE+ M ++G H NI+NL+GACT++ L
Sbjct: 141 LTDMPYRHTVAVKMLKADATENELADLLSEMDTMKNIGSHKNIINLIGACTQN---GPLY 197
Query: 691 VIVEYCKYGNIHNYMQKHR 709
V+VE+ +GN+ ++++ R
Sbjct: 198 VVVEFAPHGNLRQFLRERR 216
>UniRef50_Q59F30 Cluster: Fibroblast growth factor receptor 4
variant; n=28; Eumetazoa|Rep: Fibroblast growth factor
receptor 4 variant - Homo sapiens (Human)
Length = 1034
Score = 189 bits (460), Expect = 4e-46
Identities = 82/165 (49%), Positives = 117/165 (70%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
PL+ L+ A+Q+ARGM+YL +RK +H DLAARNVL+ +DNV+KI DFGLAR +++ +
Sbjct: 815 PLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDY 874
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
Y+K N LPVKW+A E + DR+++ QSDVWS+GI+LWE+F+L +PYP I +L L
Sbjct: 875 YKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLL 934
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFL 960
+G+R+++PP LY +M CWH P+ RP+F +L E L L
Sbjct: 935 REGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL 979
Score = 93.5 bits (222), Expect = 3e-17
Identities = 53/135 (39%), Positives = 78/135 (57%), Gaps = 5/135 (3%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINA--EVTTPVAVKMVKRTADNMY 653
LP D +EFPR++L GK LG G FG V +AEA G+ A + + VAVKM+K A +
Sbjct: 686 LPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKD 745
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFI 713
+ L SE+++M +G+H NI+NLLG CT+ + L VIVE GN+ +++ R
Sbjct: 746 LADLVSEMEVMKLIGRHKNIINLLGVCTQ---EGPLYVIVECAAKGNLREFLRARRPPGP 802
Query: 714 DQLTDNAEKNLGKIN 728
D D + G ++
Sbjct: 803 DLSPDGPRSSEGPLS 817
Score = 38.3 bits (85), Expect = 1.2
Identities = 22/89 (24%), Positives = 39/89 (43%), Gaps = 4/89 (4%)
Query: 449 GRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNG 508
G +++ C A G P PTI W KD + + ++ + H + + +E++ D G
Sbjct: 280 GNTVKFRCPAAGNPTPTIRWLKDGQAFHGEN--RIGGIRLRHQ--HWSLVMESVVPSDRG 335
Query: 509 IYECVALNNASELRRAYTLVLKAEKSYTP 537
Y C+ N +R Y L + + P
Sbjct: 336 TYTCLVENAVGSIRYNYLLDVLERSPHRP 364
>UniRef50_Q5GIT4 Cluster: Vascular endothelial growth factor receptor
2 homolog B precursor; n=8; Clupeocephala|Rep: Vascular
endothelial growth factor receptor 2 homolog B precursor
- Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 1357
Score = 189 bits (460), Expect = 4e-46
Identities = 87/189 (46%), Positives = 130/189 (68%), Gaps = 2/189 (1%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
LT L+ ++FQ+A+GME+LA+RK +H DLAARN+LL++++VVKICDFGLAR +Y + +Y
Sbjct: 1011 LTMEDLISYSFQVAKGMEFLASRKCIHRDLAARNILLSENSVVKICDFGLARDVYKDPDY 1070
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS-PTDLLRWL 915
+K ++ LP+KW+A E + DR+++TQSDV S+G++LWE+FSL +PYP + R L
Sbjct: 1071 VRKGDARLPLKWMAPETIFDRVYTTQSDVRSFGVLLWEIFSLGASPYPGVCIDESFCRRL 1130
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVD-LNAP 974
+G R+ P +A +Y ML CW +P RP+FT+L E LGN L+ + + D +
Sbjct: 1131 KEGTRMRAPDYATPEIYQTMLDCWLDRPLDRPTFTQLVEHLGNLLQASAQQDGKDYIPLT 1190
Query: 975 YNEMNAELM 983
EM EL+
Sbjct: 1191 NGEMEEELV 1199
Score = 154 bits (373), Expect = 2e-35
Identities = 99/271 (36%), Positives = 143/271 (52%), Gaps = 17/271 (6%)
Query: 443 DEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENM 502
D+ S L CE G P PTI W KD++ + SG I+ + N I+ +
Sbjct: 684 DQRVNVSDSTTLVCEVSGTPTPTIVWTKDNQTVMEGSGV-----ILKRS--NRVLTIQRV 736
Query: 503 QEKDNGIYECVALNNAS-ELRRAYTLVLKAEKSYTPYXXXXXXXXXXXXGMVAYLFTWKL 561
+++D+G+Y C A N E A V AE+ M +L +
Sbjct: 737 KKEDSGLYICTACNQQGCESSEARISVDGAEEKMN--VELIMPIGAVVIAMFLWLLIVFV 794
Query: 562 KKQRELTKAGLLNFKSGNKKSF--NPNLGIDEQADLLPYD-EKFEFPREKLTFGKQLGAG 618
+ R+ G + K+G + ++ +DE + L YD K+EFPR++L G+ LG G
Sbjct: 795 IRNRKRPNDG--DLKTGYLSIILDSDDMPMDEHCERLTYDASKWEFPRDRLKLGEPLGRG 852
Query: 619 AFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLG 678
AFG V +A A GI A T VAVKM+K A + +AL SELKI++H+G H+N+VNLLG
Sbjct: 853 AFGQVVEATAYGIEKATTCTTVAVKMLKEGATSSEYRALMSELKILIHIGHHLNVVNLLG 912
Query: 679 ACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
ACTK L+VIVEYCK+GN+ +Y++ R
Sbjct: 913 ACTKQ--GGPLMVIVEYCKHGNLSSYLKSKR 941
Score = 59.7 bits (138), Expect = 5e-07
Identities = 75/292 (25%), Positives = 130/292 (44%), Gaps = 30/292 (10%)
Query: 3 EIVVPRDCSKIVIECRPTTPDVNVTLSSEIPDYYYPS----FRYSPKIGFVPENSMPSDD 58
++V R+ ++VI C + D+NVTL ++ P + + + GF+ +PS
Sbjct: 139 DVVFIREGEQVVIPCLVSVEDLNVTLYTKYPVKELSTDGKEVIWDSRRGFI----LPS-- 192
Query: 59 QIISF---VLCEF-VRGETRIEKYIYVSKHIKKPPKPKVAGGHKQFLEGETFTIHCRVP- 113
+++S+ V C+ +R ET V+ K ++ H++ GE ++C
Sbjct: 193 RVVSYAGVVYCQTTIRNETFQSSPYIVAVVGYKIYDLTLSPQHERLTVGERLILNCTAHT 252
Query: 114 --NDGLINFKWKYPPEV--TNDSVEVSVVKTEATTT---GSIVYQN-ITIRNATKKHNGV 165
N G I+F+W +P E N S+ S KT + S+ N +T+ N T G
Sbjct: 253 ELNVG-IDFQWTFPHEKRSVNGSMSTSRYKTSSNKRKLWNSLELSNTLTVENVTLNDTGE 311
Query: 166 YTCLLTNTCGEEKDEFRKIFLEKPFLSLRDLAKGKLMGNA-NKSINIVIEIEAYPPVERT 224
Y C ++ ++ + I EKPF++L D + A + I+++ AYP
Sbjct: 312 YICTASSGQMQKIAQASLIVYEKPFIALSDQLWQTVEAKAGDAEAKILVKYYAYPE-PAV 370
Query: 225 HFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLTK 276
+ KND+ + D +Y + L I + D NYT+V NK +TK
Sbjct: 371 RWYKNDQLIVLRD-EYRMKFYRG--VHLTIYGVTEKDAGNYTVVMTNK-ITK 418
Score = 35.5 bits (78), Expect = 8.5
Identities = 26/71 (36%), Positives = 35/71 (49%), Gaps = 10/71 (14%)
Query: 462 PRPTIYWYKDDELISNNSGYKL-FVDIVNHTIVNSTFEIENMQEKDNGIYECVALNNAS- 519
P P + WYK+D+LI Y++ F V+ TI T EKD G Y V N +
Sbjct: 366 PEPAVRWYKNDQLIVLRDEYRMKFYRGVHLTIYGVT-------EKDAGNYTVVMTNKITK 418
Query: 520 -ELRRAYTLVL 529
E RR + LV+
Sbjct: 419 EEQRRTFQLVV 429
>UniRef50_A7RZ71 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 624
Score = 187 bits (456), Expect = 1e-45
Identities = 81/162 (50%), Positives = 116/162 (71%)
Query: 792 HQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMY 851
H L + +AFQIARGMEYL+ +K +H DLAARN+L+ +D V+KI DFGLAR++
Sbjct: 445 HSQPSLIVRDFISFAFQIARGMEYLSFKKCIHRDLAARNILVGEDYVMKIADFGLARNVR 504
Query: 852 NNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDL 911
+ + Y+K + LP+KWLAIE + DR+++TQSDVW++GI+LWE+F+L +PYP I L
Sbjct: 505 DMDYYRKATDGRLPIKWLAIEALFDRVYTTQSDVWTFGILLWEIFTLGGSPYPGIPVEKL 564
Query: 912 LRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQ 953
L G R++ P D++Y++ML CW++ P ARPSFTEL+
Sbjct: 565 FELLKSGYRMQMPQKCPDKMYDIMLSCWNENPNARPSFTELR 606
Score = 96.7 bits (230), Expect = 3e-18
Identities = 48/114 (42%), Positives = 72/114 (63%), Gaps = 3/114 (2%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIK 655
LP DE +E R ++T +QLG GAFG+V KAEA G+ + VAVKM+K A +
Sbjct: 321 LPIDEDWEIDRSQITIKEQLGEGAFGLVMKAEALGLTDMPYRHTVAVKMLKADATENELA 380
Query: 656 ALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
L SE+ M ++G H NI+NL+GACT++ L V+VE+ +GN+ ++++ R
Sbjct: 381 DLLSEMDTMKNIGSHKNIINLIGACTQN---GPLYVVVEFAPHGNLRQFLRERR 431
Score = 47.6 bits (108), Expect = 0.002
Identities = 41/141 (29%), Positives = 64/141 (45%), Gaps = 10/141 (7%)
Query: 189 PFLSLRDLAKGKLMG-NANKSINIVIEIEAYPPVERTHFLKNDKYLPSNDLKYNVTTLAN 247
P+ + + KG + A +I + + E PP+ T +LKN K + L+ + T
Sbjct: 5 PYFAQQQKMKGTFIAWPAWHTIKLKCKAEGTPPLTFT-WLKNGKPITHRRLQPGLKT--- 60
Query: 248 GDPKLRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRLENSEM- 306
LR+ DL D +YT V N Y N+T L+V TKP ++ + R + R + E+
Sbjct: 61 NQWYLRLRDLVPADTGDYTCVVSNPYGQINHTYTLQVVTKPRSRPILQRNLPRNTSIELG 120
Query: 307 ---NFAC-KVTGYPLPDVTWI 323
C V LPD W+
Sbjct: 121 GNATLDCIVVVSGTLPDFRWL 141
>UniRef50_Q7PYY7 Cluster: ENSANGP00000019144; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000019144 - Anopheles gambiae
str. PEST
Length = 687
Score = 187 bits (455), Expect = 2e-45
Identities = 85/194 (43%), Positives = 125/194 (64%), Gaps = 8/194 (4%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
LTSG L + +Q+ARGM++L +R ++H DLAARN+L+ DD+ K+ DFG AR + ++ Y
Sbjct: 496 LTSGDLTSFMYQVARGMDFLTSRGIIHRDLAARNILITDDHTCKVADFGFARDIVTSKVY 555
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
++K LP++W+A E + D IF+ +SD+WS+GI++WE+ +L TPYP I+ D++R +
Sbjct: 556 ERKSEGRLPIRWMATESLYDNIFTVKSDIWSFGILMWEIVTLGSTPYPGIAAADVMRKVR 615
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN----ERNRYVDLN 972
DG RLEKP LYN+M CW P RP F E+ E+L L+ E R+ D N
Sbjct: 616 DGYRLEKPEHCRRELYNIMFYCWAADPNERPGFPEVVEMLDRLLQTETDYIELERFPDHN 675
Query: 973 APYNEMNAELMTGE 986
YN +N M+GE
Sbjct: 676 Y-YNMLN---MSGE 685
Score = 77.8 bits (183), Expect = 2e-12
Identities = 41/110 (37%), Positives = 61/110 (55%), Gaps = 3/110 (2%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+++EFPR +L LG GAFG V++ EA I E + AVK +K A L S
Sbjct: 375 DRWEFPRHRLKVFNILGEGAFGQVWRCEATDIDGHEGVSVTAVKTLKENASEAERNDLLS 434
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
EL+++ L H+N+V LLG CT+ K + VI+EY G + +++ R
Sbjct: 435 ELQVLKSLEPHINVVRLLGCCTE---KDPIFVILEYVNMGKLQTFLRNSR 481
>UniRef50_Q4S1S8 Cluster: Chromosome undetermined SCAF14764, whole
genome shotgun sequence; n=1; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF14764,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 635
Score = 186 bits (454), Expect = 2e-45
Identities = 81/159 (50%), Positives = 115/159 (72%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ A+Q+ARGM YLA++K +H DLAARNVL+ +DNV+KI DFGLAR +++ + Y+K N
Sbjct: 470 LVSAAYQVARGMAYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDVHHIDYYKKTTN 529
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
LPVKW+A E + DRI++ QSDVWS+G++LWE+F+L +PYP + +L + L +G+R+
Sbjct: 530 GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRM 589
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFL 960
EKPP + LY +M CWH P RP+F +L E L L
Sbjct: 590 EKPPTSTQELYLMMRGCWHAVPARRPTFQQLVEDLDRIL 628
Score = 97.5 bits (232), Expect = 2e-18
Identities = 55/134 (41%), Positives = 78/134 (58%), Gaps = 5/134 (3%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVT--TPVAVKMVKRTADNMY 653
LPYD +E PR++LT GK LG G FG V AEA G+ + T VAVKM+K A
Sbjct: 335 LPYDPVWELPRDRLTLGKPLGEGCFGQVVLAEAVGLDKNKPARVTKVAVKMLKADATEKD 394
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFI 713
L SE+++M +GKH NI+NLLGACT+ L V+VEY GN+ +Y++ R +
Sbjct: 395 RADLISEMEMMKMIGKHKNIINLLGACTQ---DGPLYVLVEYASKGNLRDYLRARRPAGL 451
Query: 714 DQLTDNAEKNLGKI 727
+ + + +L +
Sbjct: 452 EYWSSSRPVSLASM 465
Score = 42.7 bits (96), Expect = 0.056
Identities = 25/92 (27%), Positives = 42/92 (45%), Gaps = 8/92 (8%)
Query: 449 GRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKD 506
G++++L C+A G P P++ WYK N +K I + T+ + E++ D
Sbjct: 17 GKTVKLRCQAIGSPVPSLRWYK------NGKEFKKDQRIGGFKVRGQTWTLIMESVIPSD 70
Query: 507 NGIYECVALNNASELRRAYTLVLKAEKSYTPY 538
G Y CV N L+ Y L + + P+
Sbjct: 71 KGNYTCVVENEYGRLQHTYVLDVVERSPHRPF 102
Score = 36.7 bits (81), Expect = 3.7
Identities = 35/137 (25%), Positives = 61/137 (44%), Gaps = 14/137 (10%)
Query: 49 VPENSMPSDDQIISFVLCEFVRGETRIEKYIYVSKHIKKPP-KPKVAGG---HKQFLEGE 104
+ E+ +PSD + V V E ++ YV +++ P +P + G ++ + G
Sbjct: 62 IMESVIPSDKGNYTCV----VENEYGRLQHTYVLDVVERSPHRPFLQFGLPANQTAVVGS 117
Query: 105 TFTIHCRVPNDGLINFKWKYPPEVTNDSV------EVSVVKTEATTTGSIVYQNITIRNA 158
CRV +D + +W EV +V + V+KT T + +T+RN
Sbjct: 118 DVAFVCRVFSDAQPHIQWLKHIEVNGTTVGPDGLPHIRVLKTAGLNTTDKDMEVLTLRNV 177
Query: 159 TKKHNGVYTCLLTNTCG 175
+ +G YTCL N+ G
Sbjct: 178 SLNDSGEYTCLAGNSIG 194
>UniRef50_A3EXK5 Cluster: Fibroblast growth factor receptor b; n=1;
Nematostella vectensis|Rep: Fibroblast growth factor
receptor b - Nematostella vectensis
Length = 591
Score = 186 bits (454), Expect = 2e-45
Identities = 80/183 (43%), Positives = 125/183 (68%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ +++Q+ARGMEYL ++K +H DLAARNVL++D++V+KI DFGLAR +++ + Y+K +
Sbjct: 393 LVSFSYQVARGMEYLESKKCIHRDLAARNVLVSDNHVIKIADFGLARDIHDIDYYRKTTD 452
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
LPVKW+A+E + DR+++ QSDVW+YGI++WE+ + +PYP I L L +G R+
Sbjct: 453 GRLPVKWMALEALFDRVYTAQSDVWAYGILMWEIVTFGGSPYPGIPLWKLFELLKEGYRM 512
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLNAPYNEMNAE 981
E+P D +Y +MLRCWH+ P RP+F E+ + + L Y+DL +P + A
Sbjct: 513 EQPVNCQDDVYALMLRCWHENPNQRPTFAEIVKEMDAKLTALSEQEYLDLTSPLSNPVAP 572
Query: 982 LMT 984
+ T
Sbjct: 573 IET 575
Score = 94.7 bits (225), Expect = 1e-17
Identities = 51/131 (38%), Positives = 78/131 (59%), Gaps = 5/131 (3%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIK 655
LP DE++E R +++ LG GAFG V KA+A G+ N VAVKM+ A +
Sbjct: 261 LPLDEEWELDRSQISLLGILGEGAFGRVVKADAIGLPNMPYRCNVAVKMLXEDATEHELA 320
Query: 656 ALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREV--FI 713
L SE+++M +G+HVNI+NL+GACT+ K L V+VEY GN+ +++ R + +
Sbjct: 321 DLVSEMEVMKTIGQHVNIINLIGACTQ---KGPLFVVVEYASQGNLRQFLRARRPIPEYA 377
Query: 714 DQLTDNAEKNL 724
+ LT+ + L
Sbjct: 378 NPLTEPPREKL 388
>UniRef50_Q2VJ45 Cluster: HOOK3-RET fusion protein; n=3;
Eutheria|Rep: HOOK3-RET fusion protein - Homo sapiens
(Human)
Length = 776
Score = 186 bits (454), Expect = 2e-45
Identities = 87/209 (41%), Positives = 129/209 (61%), Gaps = 5/209 (2%)
Query: 765 RSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHG 824
R RKV GY+ + R LT G L+ +A+QI++GM+YLA K++H
Sbjct: 479 RESRKVGPGYLGSGGSRNSSS---LDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHR 535
Query: 825 DLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSD 884
DLAARN+L+A+ +KI DFGL+R +Y + Y K+ +PVKW+AIE + D I++TQSD
Sbjct: 536 DLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSD 595
Query: 885 VWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPT 944
VWS+G++LWE+ +L PYP I P L L G+R+E+P + +Y +ML+CW Q+P
Sbjct: 596 VWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPD 655
Query: 945 ARPSFTELQEILGNFLEDNERNRYVDLNA 973
RP F ++ + L + +R Y+DL A
Sbjct: 656 KRPVFADISKDLEKMMV--KRRDYLDLAA 682
Score = 83.8 bits (198), Expect = 2e-14
Identities = 46/130 (35%), Positives = 72/130 (55%), Gaps = 4/130 (3%)
Query: 599 DEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALA 658
D K+EFPR+ L GK LG G FG V KA A + T VAVKM+K A ++ L
Sbjct: 376 DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLL 435
Query: 659 SELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTD 718
SE ++ + H +++ L GAC++ L++IVEY KYG++ ++++ R+V L
Sbjct: 436 SEFNVLKQV-NHPHVIKLYGACSQ---DGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGS 491
Query: 719 NAEKNLGKIN 728
+N ++
Sbjct: 492 GGSRNSSSLD 501
>UniRef50_P07949 Cluster: Proto-oncogene tyrosine-protein kinase
receptor ret precursor; n=59; Eumetazoa|Rep:
Proto-oncogene tyrosine-protein kinase receptor ret
precursor - Homo sapiens (Human)
Length = 1114
Score = 186 bits (454), Expect = 2e-45
Identities = 87/209 (41%), Positives = 129/209 (61%), Gaps = 5/209 (2%)
Query: 765 RSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHG 824
R RKV GY+ + R LT G L+ +A+QI++GM+YLA K++H
Sbjct: 817 RESRKVGPGYLGSGGSRNSSS---LDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHR 873
Query: 825 DLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSD 884
DLAARN+L+A+ +KI DFGL+R +Y + Y K+ +PVKW+AIE + D I++TQSD
Sbjct: 874 DLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSD 933
Query: 885 VWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPT 944
VWS+G++LWE+ +L PYP I P L L G+R+E+P + +Y +ML+CW Q+P
Sbjct: 934 VWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPD 993
Query: 945 ARPSFTELQEILGNFLEDNERNRYVDLNA 973
RP F ++ + L + +R Y+DL A
Sbjct: 994 KRPVFADISKDLEKMMV--KRRDYLDLAA 1020
Score = 83.8 bits (198), Expect = 2e-14
Identities = 46/130 (35%), Positives = 72/130 (55%), Gaps = 4/130 (3%)
Query: 599 DEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALA 658
D K+EFPR+ L GK LG G FG V KA A + T VAVKM+K A ++ L
Sbjct: 714 DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLL 773
Query: 659 SELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTD 718
SE ++ + H +++ L GAC++ L++IVEY KYG++ ++++ R+V L
Sbjct: 774 SEFNVLKQV-NHPHVIKLYGACSQ---DGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGS 829
Query: 719 NAEKNLGKIN 728
+N ++
Sbjct: 830 GGSRNSSSLD 839
>UniRef50_Q26614 Cluster: Fibroblast growth factor receptor
precursor; n=4; Eumetazoa|Rep: Fibroblast growth factor
receptor precursor - Strongylocentrotus purpuratus
(Purple sea urchin)
Length = 972
Score = 185 bits (451), Expect = 5e-45
Identities = 82/177 (46%), Positives = 119/177 (67%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
LT+ L+ A+Q+ARGM++LA++K +H DLAARNVL+ +D +KICDFGLAR ++ + Y
Sbjct: 753 LTNKDLMSMAYQVARGMDFLASKKCIHRDLAARNVLVTEDFEMKICDFGLARDIHYIDFY 812
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
+K + LPVKW+A E + DR+F+TQSDVWS+GI+LWE+ +L TPYP++ + +L
Sbjct: 813 RKTTDGRLPVKWMAPEALFDRMFTTQSDVWSFGILLWEIMTLGGTPYPSVPVEQMFDYLR 872
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLNA 973
G RLEKP +Y+++ CW P RP+F EL E L + + Y+DL A
Sbjct: 873 SGKRLEKPQNTSLEIYHILCECWRTSPGQRPTFCELVEDLDRIISVSSNQDYLDLEA 929
Score = 101 bits (241), Expect = 2e-19
Identities = 54/132 (40%), Positives = 81/132 (61%), Gaps = 4/132 (3%)
Query: 578 GNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVT 637
G + +L + + D+ P D ++EFPR++LT GK +G GAFG V EA GI+ E T
Sbjct: 609 GGRNRLTSSLTVISEYDI-PLDPEWEFPRDRLTVGKTIGEGAFGKVVIGEAVGIVCQEKT 667
Query: 638 TPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCK 697
+ VAVKM+K A + L SEL +M +GK+ NI+NLLG CT+ + VIVE+
Sbjct: 668 STVAVKMLKANAMDREFSDLISELAMMKMIGKNPNIINLLGCCTQ---EGPPYVIVEFAH 724
Query: 698 YGNIHNYMQKHR 709
+GN+ ++++ R
Sbjct: 725 HGNLRDFLRSRR 736
>UniRef50_Q95YM9 Cluster: Fibroblast growth factor receptor
precursor; n=4; Ascidiacea|Rep: Fibroblast growth factor
receptor precursor - Halocynthia roretzi (Sea squirt)
Length = 763
Score = 185 bits (451), Expect = 5e-45
Identities = 81/177 (45%), Positives = 120/177 (67%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
LT ++ +AFQ+ARG+E+LA +K +H DLAARNVL+ ++ V+KI DFGLAR + + + Y
Sbjct: 509 LTQKDIVSFAFQVARGLEFLAQKKCIHRDLAARNVLVTEELVMKIADFGLARDIRSCDYY 568
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
+K LP KW+A+E M D IF+ +DVWS+G++LWE+FSLA +PYP I +L+++L
Sbjct: 569 RKHTRGHLPYKWMALEAMSDNIFTHATDVWSFGVLLWEIFSLAGSPYPGIKTHELVKFLR 628
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLNA 973
G RL+KP +A +Y +M CW + P+ RP+F L E L L ++ Y+D A
Sbjct: 629 SGERLDKPQYASQEMYRLMRDCWEEDPSKRPNFRTLVEDLDRMLAESSTEVYIDFAA 685
Score = 71.7 bits (168), Expect = 1e-10
Identities = 40/112 (35%), Positives = 65/112 (58%), Gaps = 4/112 (3%)
Query: 599 DEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPV-AVKMVKRTADNMYIKAL 657
D ++E RE +T ++L G FG V+KA+ N V AVKM+K + + L
Sbjct: 372 DLQWELQREDITLVERLDEGFFGQVFKADLVTCNNTRKEKMVCAVKMLKGNRNEKDVLDL 431
Query: 658 ASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+E+ M +GKH NI+NLLG CT++ L +++EY GN+ +Y++++R
Sbjct: 432 LTEMDQMKRVGKHKNIINLLGVCTQN---GPLWLVIEYAAQGNLRDYLRRNR 480
Score = 47.6 bits (108), Expect = 0.002
Identities = 22/89 (24%), Positives = 40/89 (44%), Gaps = 6/89 (6%)
Query: 449 GRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNG 508
G +++ C +G P+P + WYK+D ++ N + + N +E++ D G
Sbjct: 91 GNTVRFRCAVDGNPKPQVLWYKNDLIVQKND------RVGGYKYRNQVLILESVVLSDKG 144
Query: 509 IYECVALNNASELRRAYTLVLKAEKSYTP 537
Y CVA N + Y L ++ + P
Sbjct: 145 NYMCVARNEYGSINHTYQLDVQERSASKP 173
Score = 41.1 bits (92), Expect = 0.17
Identities = 46/208 (22%), Positives = 88/208 (42%), Gaps = 17/208 (8%)
Query: 187 EKPFLSLRDLAKGKLMGN-ANKSINIVIEIEAYPPVERTHFLKNDKYLPSNDLKYNVTTL 245
+KP+ + R+ +L A ++ ++ P + + KND + ND V
Sbjct: 71 QKPYWTKREKMMKRLHAEPAGNTVRFRCAVDGNPKPQVLWY-KNDLIVQKND---RVGGY 126
Query: 246 ANGDPKLRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRLENS- 304
+ L + + L+D NY VA N+Y + N+T L V + +K + + + +++
Sbjct: 127 KYRNQVLILESVVLSDKGNYMCVARNEYGSINHTYQLDVQERSASKPILAEGLPQNKSAY 186
Query: 305 ---EMNFACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYL--------KISV 353
++ F CKV P + W+ S + + + + ++ T L +S
Sbjct: 187 IGDDVTFKCKVYSDAHPHIQWLKSINNHNNAAPNYTVLKAAGVNTTDLDMEVLILKNVSF 246
Query: 354 QASGVITCNAHNSKGEYFDSSTLLVYEI 381
+ +G TC A NS G S+ L V +
Sbjct: 247 EEAGEYTCLAGNSIGISHQSAWLSVLPV 274
Score = 36.7 bits (81), Expect = 3.7
Identities = 24/90 (26%), Positives = 42/90 (46%), Gaps = 4/90 (4%)
Query: 90 KPKVAGG---HKQFLEGETFTIHCRVPNDGLINFKW-KYPPEVTNDSVEVSVVKTEATTT 145
KP +A G +K G+ T C+V +D + +W K N + +V+K T
Sbjct: 172 KPILAEGLPQNKSAYIGDDVTFKCKVYSDAHPHIQWLKSINNHNNAAPNYTVLKAAGVNT 231
Query: 146 GSIVYQNITIRNATKKHNGVYTCLLTNTCG 175
+ + + ++N + + G YTCL N+ G
Sbjct: 232 TDLDMEVLILKNVSFEEAGEYTCLAGNSIG 261
>UniRef50_Q03142 Cluster: Fibroblast growth factor receptor 4
precursor; n=9; Eutheria|Rep: Fibroblast growth factor
receptor 4 precursor - Mus musculus (Mouse)
Length = 799
Score = 185 bits (451), Expect = 5e-45
Identities = 86/189 (45%), Positives = 125/189 (66%), Gaps = 4/189 (2%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
PL+ L+ A+Q+ARGM+YL +RK +H DLAARNVL+ +D+V+KI DFGLAR +++ +
Sbjct: 580 PLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDY 639
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
Y+K N LPVKW+A E + DR+++ QSDVWS+ I+LWE+F+L +PYP I +L L
Sbjct: 640 YKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFEILLWEIFTLGGSPYPGIPVEELFSLL 699
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLN--- 972
+G+R+E+PP LY +M CWH P+ RP+F +L E L L Y+DL
Sbjct: 700 REGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALDKVLL-AVSEEYLDLRLTF 758
Query: 973 APYNEMNAE 981
P++ N +
Sbjct: 759 GPFSPSNGD 767
Score = 94.7 bits (225), Expect = 1e-17
Identities = 53/135 (39%), Positives = 78/135 (57%), Gaps = 5/135 (3%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGI--INAEVTTPVAVKMVKRTADNMY 653
LP D +EFPR++L GK LG G FG V +AEA G+ + T+ VAVKM+K A +
Sbjct: 451 LPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTSTVAVKMLKDNASDKD 510
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFI 713
+ L SE+++M +G+H NI+NLLG CT+ + L VIVE GN+ +++ R
Sbjct: 511 LADLVSEMEVMKLIGRHKNIINLLGVCTQ---EGPLYVIVECAAKGNLREFLRARRPPGP 567
Query: 714 DQLTDNAEKNLGKIN 728
D D + G ++
Sbjct: 568 DLSPDGPRSSEGPLS 582
Score = 41.9 bits (94), Expect = 0.098
Identities = 22/89 (24%), Positives = 42/89 (47%), Gaps = 4/89 (4%)
Query: 449 GRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNG 508
G +++ C A G P PTI+W KD + + ++ + H + + +E++ D G
Sbjct: 162 GNTVKFRCPAAGNPMPTIHWLKDGQAFHGEN--RIGGIRLRHQ--HWSLVMESVVPSDRG 217
Query: 509 IYECVALNNASELRRAYTLVLKAEKSYTP 537
Y C+ N+ +R +Y L + + P
Sbjct: 218 TYTCLVENSLGSIRYSYLLDVLERSPHRP 246
>UniRef50_Q7Q0U2 Cluster: ENSANGP00000012311; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000012311 - Anopheles gambiae
str. PEST
Length = 410
Score = 184 bits (448), Expect = 1e-44
Identities = 120/377 (31%), Positives = 186/377 (49%), Gaps = 30/377 (7%)
Query: 603 EFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELK 662
E P L G+++G GAFG V+ A A + VA+K +K+ + + E+
Sbjct: 7 EVPHSCLRIGREIGKGAFGRVFMASAIKLPGFSGPKIVAIKQLKKCSSSDEFDEFLDEIT 66
Query: 663 IMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVF---IDQLTDN 719
+M +GKH NIV LLG CT K L +I+EY G++ Y++K R + QL
Sbjct: 67 MMKKVGKHPNIVALLGCCT---IKEPLTMIMEYVGCGDLLEYLRKIRAKHLAKVHQLDIG 123
Query: 720 AE---KNLGKINKGFLNSVGTTGTHSDYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQ 776
A+ N G N G + D + + D + ++ S + YI
Sbjct: 124 AQLENANSGLNTAPGNNIFGPMVKYLDLLHTSSNSDASYITQTDTTTRPSVTESKYAYIL 183
Query: 777 QEWQT-----------KYEGDYI------YECHQPRPLTSGHLLGWAFQIARGMEYLANR 819
+ T + + +C L L +A QIA GME+L
Sbjct: 184 ERHTTLLSETLKKRTYNVNANSVTKHYSEIDCSLEYVLDHKELHNFAKQIAFGMEHLEGL 243
Query: 820 KVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIF 879
+ H DLAARN+L+ + +KI DFGL+R+ Y N +P++WL+IE M D ++
Sbjct: 244 HITHRDLAARNILIDERKTLKISDFGLSRTGI----YVNTRNKKVPLRWLSIEAMRDNLY 299
Query: 880 STQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCW 939
S +SDVW++GIVLWE+ +L PYP++S +L +L +G RLE+P +Y++ML+CW
Sbjct: 300 SNKSDVWAFGIVLWEIGTLGGYPYPSVSNHELFAYLQEGKRLERPENCTVDVYDLMLQCW 359
Query: 940 HQKPTARPSFTELQEIL 956
+ P RPSF ++ + L
Sbjct: 360 REDPNERPSFQQISKHL 376
>UniRef50_Q7Z1L9 Cluster: Neurite outgrowth regulated kinase; n=1;
Aplysia californica|Rep: Neurite outgrowth regulated
kinase - Aplysia californica (California sea hare)
Length = 991
Score = 184 bits (447), Expect = 2e-44
Identities = 83/179 (46%), Positives = 124/179 (69%), Gaps = 1/179 (0%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
+T +L +A Q+A MEYLA +K +H DLAARNVL+ + VVK+CDFGL+R ++N+ Y
Sbjct: 707 VTPVDMLSFARQVAMAMEYLAEKKYVHRDLAARNVLIDYNKVVKVCDFGLSRDIFNDNHY 766
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
+K N LP+KW+AIE + DR+F+TQSDVWS+GI+LWE+ ++ +PYPN++ DL LS
Sbjct: 767 KKLTNGKLPLKWMAIESLRDRMFTTQSDVWSFGILLWEIVTMGASPYPNVALADLYYVLS 826
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFL-EDNERNRYVDLNAP 974
+G R+++P LY +M CW + T RP+FT+L+ +L + L ED + D++ P
Sbjct: 827 NGYRMDRPSNCSQELYAIMRACWEDESTDRPNFTQLRLMLEDLLIEDRDYLVLEDIDVP 885
Score = 69.3 bits (162), Expect = 6e-10
Identities = 42/130 (32%), Positives = 67/130 (51%), Gaps = 12/130 (9%)
Query: 582 SFNPNLG--IDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTP 639
S+ N+G D L+ + +++E L F LG GAFG V +
Sbjct: 557 SYKSNVGGKSDYSNQLIVFSDEWELDPHSLKFSTLLGQGAFGKV-------VTGYYEDQK 609
Query: 640 VAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYG 699
VA+K+V+ A Y + L +E+ +M +G H NIV L+GACT + +++EY YG
Sbjct: 610 VAIKIVREGAPLSYKEDLVAEINLMKRIGSHPNIVCLIGACT---MSEPIALVMEYVPYG 666
Query: 700 NIHNYMQKHR 709
N+ N+++K R
Sbjct: 667 NLQNFLKKCR 676
>UniRef50_Q9VBW3 Cluster: Tyrosine kinase receptor Cad96Ca
precursor; n=2; Diptera|Rep: Tyrosine kinase receptor
Cad96Ca precursor - Drosophila melanogaster (Fruit fly)
Length = 773
Score = 182 bits (443), Expect = 5e-44
Identities = 79/190 (41%), Positives = 119/190 (62%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
LTS L + +Q+A+GM+YL +R ++H DLAARN+L+ DD+ K+ DFG AR + ++ Y
Sbjct: 582 LTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKIY 641
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
++K LP++W+A E + D IFS +SD+WS+GI++WE+ +L TPYP IS D++R +
Sbjct: 642 ERKSEGKLPIRWMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISAADVMRKVR 701
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLNAPYN 976
DG RLEKP LYN+M CW P RP F E+ ++L L ++ +N
Sbjct: 702 DGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFAEIIQMLDKLLHTEMDYIELERFPDHN 761
Query: 977 EMNAELMTGE 986
N ++GE
Sbjct: 762 YYNIVSLSGE 771
Score = 86.6 bits (205), Expect = 3e-15
Identities = 47/110 (42%), Positives = 65/110 (59%), Gaps = 3/110 (2%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+++EFPR +L F LG GAFG V++ EA I E T VAVK +K +A + K L S
Sbjct: 461 DRWEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTLKESATEVDRKDLLS 520
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
EL++M L H+N+V+LLG CT K VI+EY G + Y++ R
Sbjct: 521 ELEVMKSLEPHINVVHLLGCCTD---KDPTFVILEYVNRGKLQTYLRSSR 567
>UniRef50_A7SL46 Cluster: Predicted protein; n=2; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 252
Score = 182 bits (442), Expect = 7e-44
Identities = 82/176 (46%), Positives = 115/176 (65%), Gaps = 2/176 (1%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
+T LL +++QIA GMEYL+ + +H DLAARNVL+AD+ VK+ DFGL R +Y Y
Sbjct: 78 ITPQDLLSFSYQIAAGMEYLSKKGFVHRDLAARNVLVADNKQVKVADFGLTRDLYEESAY 137
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
Q N LP+KW++ E + D+IF+T+SDVWSYG+VLWE+ +L PYP IS D+ L
Sbjct: 138 QGHSNRKLPIKWMSPEAIYDQIFTTESDVWSYGVVLWEIATLGGAPYPTISTRDVFVMLR 197
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLN 972
G R+EKP D +Y +M CW +P RP+F++L+ LE + N Y+DL+
Sbjct: 198 SGYRMEKPDICSDEVYTIMKHCWEDQPKKRPTFSDLRMKFEYMLEAD--NPYLDLS 251
Score = 36.3 bits (80), Expect = 4.9
Identities = 18/63 (28%), Positives = 35/63 (55%), Gaps = 3/63 (4%)
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDN 719
E+ +M LG H NIVN L T K +++VE+ G++ +Y++++R D+ +
Sbjct: 17 EISLMKKLGSHKNIVNFLCCST---VKEPFMLVVEFLPKGDLLDYLRRNRSKQNDETGEQ 73
Query: 720 AEK 722
++
Sbjct: 74 EDE 76
>UniRef50_Q17J18 Cluster: Tyrosine-protein kinase; n=4;
Endopterygota|Rep: Tyrosine-protein kinase - Aedes
aegypti (Yellowfever mosquito)
Length = 959
Score = 180 bits (438), Expect = 2e-43
Identities = 85/196 (43%), Positives = 124/196 (63%), Gaps = 2/196 (1%)
Query: 783 YEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKIC 842
YE D I + + LT L+ +A+QIARGME+LA+R+ +H DLAARNVL++D V+KI
Sbjct: 729 YE-DMISGEKEKKILTQKELISFAYQIARGMEHLASRRCIHRDLAARNVLVSDGYVMKIA 787
Query: 843 DFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTP 902
DFGLAR +++ E Y+K LP++W+A E + ++ + +QSDVWS+G++LWE+ +L P
Sbjct: 788 DFGLARDIHSQEYYRKTTTGKLPIRWMAPESLEEKFYDSQSDVWSFGVLLWEIMTLGGNP 847
Query: 903 YPNISPTD-LLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
Y +I D LL L G RLE+PP +Y M CWH +P RP+F+E+ + L +
Sbjct: 848 YSSIPTWDNLLEHLKKGKRLEQPPLCSIDIYLFMRECWHYRPEERPTFSEIVQHLDRLVS 907
Query: 962 DNERNRYVDLNAPYNE 977
Y+DL P E
Sbjct: 908 ITSNEEYLDLGLPLLE 923
Score = 111 bits (268), Expect = 8e-23
Identities = 54/113 (47%), Positives = 73/113 (64%), Gaps = 3/113 (2%)
Query: 597 PYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKA 656
P D +EFPR KL GK LG GAFG V AEA G++ + +T VAVKM+K + +K
Sbjct: 614 PIDLNWEFPRSKLVLGKSLGEGAFGKVVMAEANGLVKGQASTVVAVKMLKEGHTDADVKD 673
Query: 657 LASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
L E+++M +GKHVNI+NLLG C K L VIVEY +GN+ ++++ HR
Sbjct: 674 LVCEMEVMKMIGKHVNIINLLGCCCK---DGPLYVIVEYAPHGNLKDFLRSHR 723
Score = 42.7 bits (96), Expect = 0.056
Identities = 28/89 (31%), Positives = 42/89 (47%), Gaps = 8/89 (8%)
Query: 449 GRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNG 508
G ++L C A+G P P I W KDDE I + G V +IV +E++ KD+G
Sbjct: 324 GNMVRLRCPADGNPVPNITWTKDDEKIVRSMG---SVKYAKWSIV-----LEDLVPKDSG 375
Query: 509 IYECVALNNASELRRAYTLVLKAEKSYTP 537
Y C N+ + L +K ++ P
Sbjct: 376 KYTCHVCNSHGCINFTTKLEVKDRVNHKP 404
>UniRef50_UPI0000DB7F8D Cluster: PREDICTED: similar to Cad96Ca
CG10244-PA; n=3; Endopterygota|Rep: PREDICTED: similar
to Cad96Ca CG10244-PA - Apis mellifera
Length = 657
Score = 179 bits (435), Expect = 5e-43
Identities = 78/187 (41%), Positives = 123/187 (65%), Gaps = 5/187 (2%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
LTS L G+ +QIA+GMEYLA++ ++H DLAARN+L+ ++ K+ DFG AR + N+ Y
Sbjct: 466 LTSRDLTGFVYQIAKGMEYLASKGIIHRDLAARNILIDENRACKVADFGFARDVAANQIY 525
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
++K LP++W+A E + D IFS +SD+WS+G+++WE+ +L TPYP ++ +++R +
Sbjct: 526 ERKSEGRLPIRWMAPESLYDNIFSVKSDIWSFGVLIWEIVTLGSTPYPGLAAAEVMRRIK 585
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN----ERNRYVDLN 972
+G RL++P LYN+M CW + P RPSF EL + L D E +R+ D +
Sbjct: 586 EGYRLDRPEHCKRELYNIMYYCWDKDPACRPSFGELVSLTEGLLLDETDYIELDRFPD-H 644
Query: 973 APYNEMN 979
+ YN +N
Sbjct: 645 SYYNVLN 651
Score = 78.6 bits (185), Expect = 9e-13
Identities = 43/112 (38%), Positives = 62/112 (55%), Gaps = 3/112 (2%)
Query: 599 DEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALA 658
++K+EFPR +L LG G FG V+K EA I VAVK +K A LA
Sbjct: 349 EDKWEFPRHRLKVFNILGEGCFGQVWKCEALDIDGKSGAIIVAVKTLKENATERERLDLA 408
Query: 659 SELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHRE 710
EL++M +L H N+V LLG CT+ + + VI+EY G + ++++ RE
Sbjct: 409 QELRVMKNLDPHPNVVRLLGCCTE---REPMFVILEYVSGGKLQSFLRASRE 457
>UniRef50_Q09147 Cluster: Fibroblast growth factor receptor homolog 2
precursor; n=4; Coelomata|Rep: Fibroblast growth factor
receptor homolog 2 precursor - Drosophila melanogaster
(Fruit fly)
Length = 1052
Score = 178 bits (433), Expect = 8e-43
Identities = 86/180 (47%), Positives = 119/180 (66%), Gaps = 4/180 (2%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L +AFQIARGMEYLA+R+ +H DLAARNVL++D V+KI DFGLAR + + E Y+K N
Sbjct: 841 LTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTN 900
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNI-SPTDLLRWLSDGNR 920
LP+KW+A E + ++ + +QSDVWSYG++LWE+ + PYP+I S +L +L G R
Sbjct: 901 GRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQR 960
Query: 921 LEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE---DNERNRYVDLNAPYNE 977
+EKP +Y VM +CWH + ARP+F EL E L+ N + Y+DL+ P E
Sbjct: 961 MEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQASSNPNDAYLDLSMPMLE 1020
Score = 92.3 bits (219), Expect = 7e-17
Identities = 51/128 (39%), Positives = 78/128 (60%), Gaps = 7/128 (5%)
Query: 584 NPNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAE--VTTPVA 641
+P G +E P D +E PR++L+ G LG GAFG V AEA G+ + T VA
Sbjct: 689 DPAQGFNEYE--FPLDSNWEIPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVA 746
Query: 642 VKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNI 701
VKMVK + + +L E+++M +GKH+NI+NLLG C++ L VIVEY +GN+
Sbjct: 747 VKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQ---GGPLWVIVEYAPHGNL 803
Query: 702 HNYMQKHR 709
++++++R
Sbjct: 804 KDFLKQNR 811
>UniRef50_P08581 Cluster: Hepatocyte growth factor receptor precursor;
n=81; Tetrapoda|Rep: Hepatocyte growth factor receptor
precursor - Homo sapiens (Human)
Length = 1390
Score = 177 bits (432), Expect = 1e-42
Identities = 84/188 (44%), Positives = 118/188 (62%), Gaps = 5/188 (2%)
Query: 790 ECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARS 849
E H P T L+G+ Q+A+GM+YLA++K +H DLAARN +L + VK+ DFGLAR
Sbjct: 1172 ETHNP---TVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARD 1228
Query: 850 MYNNEEYQ--KKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS 907
MY+ E Y K + LPVKW+A+E + + F+T+SDVWS+G+VLWE+ + PYP+++
Sbjct: 1229 MYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVVLWELMTRGAPPYPDVN 1288
Query: 908 PTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNR 967
D+ +L G RL +P + D LY VML+CWH K RPSF+EL +
Sbjct: 1289 TFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEH 1348
Query: 968 YVDLNAPY 975
YV +NA Y
Sbjct: 1349 YVHVNATY 1356
>UniRef50_Q4SR43 Cluster: Chromosome 11 SCAF14528, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 11 SCAF14528, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 1373
Score = 176 bits (429), Expect = 3e-42
Identities = 80/191 (41%), Positives = 116/191 (60%), Gaps = 3/191 (1%)
Query: 787 YIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGL 846
+ C + P T L+G+ Q+A GMEYLA +K +H DLAARN +L + VK+ DFG+
Sbjct: 1180 HFIRCEKRNP-TVKDLIGFGLQVATGMEYLAQKKFVHRDLAARNCMLDESYTVKVADFGM 1238
Query: 847 ARSMYNNEEY--QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYP 904
AR + + E Y Q + LPVKW+AIE + + F+ +SDVWS+G+++WEM + +PYP
Sbjct: 1239 ARDVLDKEYYSVQNHRKAKLPVKWMAIESLQTQKFTPKSDVWSFGVLMWEMLTRGASPYP 1298
Query: 905 NISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
++ P D+ +L G RL +P F D LY +ML+CW +P RPSF L + L + E
Sbjct: 1299 DVDPYDITHYLLRGRRLPQPQFCPDPLYRIMLQCWDPEPELRPSFATLVSAVSIILSNLE 1358
Query: 965 RNRYVDLNAPY 975
Y+ LN Y
Sbjct: 1359 GEHYISLNVTY 1369
>UniRef50_UPI0000D57178 Cluster: PREDICTED: similar to CG14396-PA,
isoform A; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG14396-PA, isoform A - Tribolium castaneum
Length = 1065
Score = 175 bits (426), Expect = 6e-42
Identities = 85/195 (43%), Positives = 120/195 (61%), Gaps = 4/195 (2%)
Query: 784 EGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
E D Y+ +T +L +A+QI +GM YL+ K++H DLAARNVLLA D + KI D
Sbjct: 856 ENDVHYDEPNISKVTPKEILSFAWQICKGMAYLSEIKLVHRDLAARNVLLAADQICKISD 915
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGL R +Y ++ Y K+ +PVKW+A E + D I++ +SDVWS+GI++WE+ +L TPY
Sbjct: 916 FGLTRDIYEDDAYFKRSKGRVPVKWMAPESLSDHIYTNKSDVWSFGILVWELVTLGATPY 975
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P I+ +L L G R+E+P LYN+M CWH P RP+F EL + L D
Sbjct: 976 PGIAVQNLFHLLRQGYRMERPDNCSPTLYNIMRSCWHIDPEQRPTFQELAALWEKMLSDE 1035
Query: 964 ERNRYVDL--NAPYN 976
+Y+DL NA +N
Sbjct: 1036 V--QYLDLANNAIHN 1048
Score = 73.7 bits (173), Expect = 3e-11
Identities = 39/113 (34%), Positives = 64/113 (56%), Gaps = 3/113 (2%)
Query: 599 DEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALA 658
D K+EFPR +L + LG G FG V +A+A I T VAVK +K A + L
Sbjct: 733 DPKWEFPRNRLIIEQTLGEGEFGKVLRAKALNISGQPGLTTVAVKTLKDDARESELNDLL 792
Query: 659 SELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREV 711
SE +++ + H N++ LLG CT + +I+E+ ++G++ NY+++ R +
Sbjct: 793 SEYQLLKEV-SHPNVIRLLGVCT--APGGPIYLIIEFAEHGSLRNYLRRSRHL 842
>UniRef50_P79950 Cluster: Tyrosine kinase receptor; n=3; Xenopus|Rep:
Tyrosine kinase receptor - Xenopus laevis (African clawed
frog)
Length = 1369
Score = 175 bits (426), Expect = 6e-42
Identities = 81/194 (41%), Positives = 129/194 (66%), Gaps = 8/194 (4%)
Query: 793 QPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYN 852
+ R T L+G+ Q++RGMEYLANRK +H DLAARN +L + VK+ DFGLAR +++
Sbjct: 1151 EERNPTVKDLVGFGLQVSRGMEYLANRKFVHRDLAARNCMLDESFHVKVADFGLARDVFD 1210
Query: 853 NEEY--QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTD 910
E Y ++ +N+ LPVKW+A+E + + F+T+SDVWS+G++LWE+ + PYP++ D
Sbjct: 1211 KEYYSVRRHKNARLPVKWMAMESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVDAYD 1270
Query: 911 LLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTEL---QEILGNFLEDNERNR 967
+ R+L G RL +P + + LY++ML CW+ +P RP+FT+L E++ N L +
Sbjct: 1271 ITRYLFRGRRLAQPEYCPNPLYSLMLSCWNPQPVERPTFTQLVSDMELISNSLSG---DH 1327
Query: 968 YVDLNAPYNEMNAE 981
Y++LN Y ++ +
Sbjct: 1328 YINLNVTYVNLDCD 1341
>UniRef50_Q674V1 Cluster: Vascular endothelial growth factor receptor;
n=1; Podocoryne carnea|Rep: Vascular endothelial growth
factor receptor - Podocoryne carnea
Length = 1254
Score = 174 bits (424), Expect = 1e-41
Identities = 90/251 (35%), Positives = 143/251 (56%), Gaps = 10/251 (3%)
Query: 789 YECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLAR 848
Y+ T LL Q+A+ M++L ++K +H DLAARNVL+ D ++KI DFGLAR
Sbjct: 971 YDTDMENEFTYIDLLMIVIQVAKRMDFLQSQKCVHRDLAARNVLVGPDYIMKIADFGLAR 1030
Query: 849 SMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISP 908
+Y +E Y K+ LPVKW+A E + D+++++ SD+WSYGIVLWE F+L +PYP +
Sbjct: 1031 DIYKDEFYLKETTGLLPVKWMAPESLFDKVYTSMSDIWSYGIVLWEAFTLGGSPYPGLPT 1090
Query: 909 TDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN--ERN 966
DL +L DG R+E+P ++ +M CW + P RP F+++ + L N L+ N +
Sbjct: 1091 EDLFGFLEDGKRMERPEICPKSVFEIMSDCWTKSPYDRPMFSQIYDRLTNVLKHNVPSDS 1150
Query: 967 RYVDL-NAPYNE-MNAELMTGEDYLAMVCAPDYN---NIVTPSPNYVNMAKSFFPATPTP 1021
Y+D +A N+ + ++ + A +++ P P+ ++ P P P
Sbjct: 1151 DYLDFTDAKENDYLTPDIKANSNEYLEASAENFSPKGQTYVPPPS-KDLFDESSPLPPEP 1209
Query: 1022 KDQEGYLPMSP 1032
D GY+PM+P
Sbjct: 1210 TD--GYVPMTP 1218
Score = 70.5 bits (165), Expect = 2e-10
Identities = 38/73 (52%), Positives = 48/73 (65%), Gaps = 3/73 (4%)
Query: 640 VAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYG 699
VAVK +K A K LASELKI++HLG+H NIVNLLGACT +L VI+E C G
Sbjct: 895 VAVKTLKDDAAEGEYKDLASELKILIHLGEHKNIVNLLGACT---TNGKLYVILECCPRG 951
Query: 700 NIHNYMQKHREVF 712
N+ +++ RE F
Sbjct: 952 NLLTFLRGKRETF 964
Score = 63.7 bits (148), Expect = 3e-08
Identities = 50/196 (25%), Positives = 82/196 (41%), Gaps = 13/196 (6%)
Query: 439 DSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFE 498
+S K+ + +++ C A+ P + WY+ ++ +++ DI+
Sbjct: 659 NSGKEWKVTLSGVVEVSCVAKANPPANVSWYRIEKDARKPISWRMGADILY--------- 709
Query: 499 IENMQEKDNGIYECVALNNASELRRAYTLVLKAEKSYTPYXXXXXXXXXXXXGMVAYLFT 558
+ N E + Y C A N + R Y +L + + V +
Sbjct: 710 VGNSVEDTSSGYNCTASNELGNVTR-YVQILAGDSAVVGGASSKGTIIGVIVATVIIVLI 768
Query: 559 WK---LKKQRELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTFGKQL 615
L +R L K L + +P+ I EQ+ LPYD +EFPR K++ K L
Sbjct: 769 ALILILWYRRHLKKRYALFLEPNEDWQIDPDRTIFEQSSELPYDMDWEFPRSKISLIKTL 828
Query: 616 GAGAFGVVYKAEARGI 631
G+GAFG V+ AEA GI
Sbjct: 829 GSGAFGQVWLAEAEGI 844
>UniRef50_Q17IF1 Cluster: Receptor protein tyrosine kinase; n=1;
Aedes aegypti|Rep: Receptor protein tyrosine kinase -
Aedes aegypti (Yellowfever mosquito)
Length = 636
Score = 174 bits (424), Expect = 1e-41
Identities = 86/197 (43%), Positives = 121/197 (61%), Gaps = 1/197 (0%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
+TS LL +A QIA GME+LA KV+H DLAARNVL+ D VKI DFGL+R +Y Y
Sbjct: 438 ITSRQLLEFAKQIAIGMEFLARNKVVHRDLAARNVLVCYDKAVKISDFGLSRDIYQQNLY 497
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
+K LP+KWLA+E + +++++QSDVWSYGI+L+E+ +L PYP +S DL+ L
Sbjct: 498 RKTGTGKLPIKWLALESLTHQVYTSQSDVWSYGILLYEICTLGGNPYPLLSTCDLIMELK 557
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLNAPYN 976
G R+EKP LY +ML CW P RP+FT + + + N + +DL+A +
Sbjct: 558 RGYRMEKPDSCSKELYELMLSCWSALPIDRPTFTSIHNRMEELMFQNMKKDMIDLDAIID 617
Query: 977 EMNAELMTGE-DYLAMV 992
+ + + E YL V
Sbjct: 618 IQSTKTSSSEHSYLKPV 634
Score = 59.7 bits (138), Expect = 5e-07
Identities = 38/117 (32%), Positives = 67/117 (57%), Gaps = 9/117 (7%)
Query: 593 ADLL-PYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTT--PVAVKMVKRTA 649
+DL+ P +++ E +++ +G GAFG V K GI+ V T VAVKM+K
Sbjct: 130 SDLIAPINDEMEISVDQIRLLDLVGEGAFGRVRK----GILLHPVGTYTEVAVKMLKECP 185
Query: 650 DNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
+K E+++M +G H NIV ++G T+++ E++++ EYC GN+ N+++
Sbjct: 186 SLEDVKEFRREIEVMKSVGVHPNIVCIIGHYTQNV--NEMMLLTEYCSEGNLLNFLR 240
>UniRef50_A7RGW8 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 337
Score = 174 bits (424), Expect = 1e-41
Identities = 82/179 (45%), Positives = 115/179 (64%), Gaps = 2/179 (1%)
Query: 795 RPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNE 854
R LT LL +A QIA GMEYL+ + +H DLAARN+L+ +DN+VKI DFGL R +Y +
Sbjct: 133 RELTQNDLLSFARQIAVGMEYLSQKMFVHRDLAARNILICEDNLVKISDFGLTRDVYESS 192
Query: 855 EYQKKENS-PLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
EY K N+ LP+KW+A E + + +T+SDVW++G+VLWE+ +L +PYP S + +
Sbjct: 193 EYHKMHNTGKLPLKWMAPEAIFQNVHTTKSDVWAFGVVLWEIVTLGGSPYPGQSGKEFYK 252
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLN 972
L +G R+EKP LY +M CW P RP+FT+L+ L L D E Y+D+N
Sbjct: 253 KLKNGYRMEKPDMCSPELYAMMRSCWASSPEDRPTFTKLRNQLEQ-LMDREDELYIDVN 310
Score = 76.6 bits (180), Expect = 4e-12
Identities = 43/117 (36%), Positives = 67/117 (57%), Gaps = 5/117 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVT--TPVAVKMVKRTADNMY 653
+P +++E + FG+ +G+GAFG V KA G+ T VAVK + A
Sbjct: 5 IPEPDEWEVDYSSIAFGEVVGSGAFGKVTKATIVGLPGGPENKETVVAVKKLNAMATMED 64
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHRE 710
+ SE+++M LGKH+NIV++LG C H +L +I EYC YG++ NY++ R+
Sbjct: 65 RRNFLSEIEMMKQLGKHLNIVSILG-CVTHAG--QLCLITEYCPYGDLRNYLRAIRD 118
>UniRef50_Q64GK4 Cluster: C-Met receptor tyrosine kinase; n=9;
Clupeocephala|Rep: C-Met receptor tyrosine kinase - Danio
rerio (Zebrafish) (Brachydanio rerio)
Length = 1382
Score = 174 bits (423), Expect = 1e-41
Identities = 84/197 (42%), Positives = 118/197 (59%), Gaps = 7/197 (3%)
Query: 790 ECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARS 849
E H P T L+G+ Q+A+GMEYLA++K +H DLAARN +L + VK+ D GLAR
Sbjct: 1173 ESHNP---TVKDLMGFGLQVAKGMEYLASKKFVHRDLAARNCMLDESYTVKVADVGLARD 1229
Query: 850 MYNNEEYQ--KKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS 907
+Y+ E Y K LPVKW+A+E + F+T+SDVWS+G++LWE+ + PY +++
Sbjct: 1230 VYDKEYYSVHNKHGVKLPVKWMALESLQTHKFTTKSDVWSFGVLLWELMTRGAPPYSDVN 1289
Query: 908 PTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNR 967
D+ +L G RL +P F D LYNVM+ CWH KP RP+F EL +
Sbjct: 1290 SFDITVFLLQGRRLLQPEFCPDALYNVMIECWHPKPERRPTFLELVSRISAIFSSFSGEH 1349
Query: 968 YVDLNAPYNEMNAELMT 984
Y+ LN Y +N + MT
Sbjct: 1350 YILLNTTY--VNIDKMT 1364
>UniRef50_Q07407 Cluster: Fibroblast growth factor receptor homolog
1 precursor; n=3; Sophophora|Rep: Fibroblast growth
factor receptor homolog 1 precursor - Drosophila
melanogaster (Fruit fly)
Length = 729
Score = 174 bits (423), Expect = 1e-41
Identities = 80/176 (45%), Positives = 116/176 (65%), Gaps = 1/176 (0%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
+T L+ +A QIARGM+YLA+R+ +H DLAARNVL++DD V+KI DFGLAR + + + Y
Sbjct: 528 ITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYY 587
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNI-SPTDLLRWL 915
+K N LP+KW+A E + ++ + ++SDVWSYGI+LWE+ + + PYP I S +L +L
Sbjct: 588 RKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYL 647
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDL 971
G R+EKP +Y +M +CWH RP FTE+ E + L+ E VD+
Sbjct: 648 MSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDI 703
Score = 87.8 bits (208), Expect = 2e-15
Identities = 50/125 (40%), Positives = 72/125 (57%), Gaps = 10/125 (8%)
Query: 597 PYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKA 656
P D +E PR L G LG GAFG V AE I VAVKMVK + I +
Sbjct: 404 PLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNAI-------VAVKMVKEGHTDDDIAS 456
Query: 657 LASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQL 716
L E+++M +G+H+NI+NLLG C+++ L VIVEY +GN+ +++ K+R DQ
Sbjct: 457 LVREMEVMKIIGRHINIINLLGCCSQN---GPLYVIVEYAPHGNLKDFLYKNRPFGRDQD 513
Query: 717 TDNAE 721
D+++
Sbjct: 514 RDSSQ 518
>UniRef50_Q86PM4 Cluster: Fibroblast growth factor receptor
precursor; n=1; Hydra vulgaris|Rep: Fibroblast growth
factor receptor precursor - Hydra attenuata (Hydra)
(Hydra vulgaris)
Length = 816
Score = 173 bits (422), Expect = 2e-41
Identities = 76/177 (42%), Positives = 116/177 (65%)
Query: 795 RPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNE 854
+ +T L + Q+ARGM +LA++K +H D+AARNVL+ + ++KI DFGLAR ++ +
Sbjct: 582 KKITLYDLTSFCLQVARGMNFLASKKCIHRDIAARNVLVGEGYLMKIADFGLARDIHEQD 641
Query: 855 EYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRW 914
Y+K + LPVKW+AIE + DR+++TQSD+WS+GI+ WE+ + +PYP I+ L
Sbjct: 642 YYRKCTDGRLPVKWMAIEALFDRVYTTQSDIWSFGILAWEIVTFGGSPYPGIALEKLFDL 701
Query: 915 LSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDL 971
L G R+E+P D +Y +ML CW + P+ RP+F++L E L L D Y+DL
Sbjct: 702 LKQGYRMERPLNCTDDMYTLMLNCWKEIPSKRPTFSQLIEDLERMLLDASSTEYIDL 758
Score = 85.4 bits (202), Expect = 8e-15
Identities = 49/134 (36%), Positives = 78/134 (58%), Gaps = 5/134 (3%)
Query: 580 KKSFNPNLGIDEQADLLPY--DEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVT 637
+ S N NL D+Q L D +E E+L LG GAFG V++A AR + N
Sbjct: 443 RHSLNNNLINDKQKLNLKIAPDPAWEIKLEQLETDCLLGEGAFGRVFRATARDLPNHTGV 502
Query: 638 TPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCK 697
VAVKM+K +K SE+++M +GKH+NI+NLL ++ + +L ++VEYC+
Sbjct: 503 QTVAVKMLKEDCCEQDLKDFISEIEVMKSIGKHINILNLLAVSSQ---QGKLYIVVEYCR 559
Query: 698 YGNIHNYMQKHREV 711
+GN+ ++++ +R V
Sbjct: 560 HGNLRSFLKDNRPV 573
>UniRef50_Q10656-2 Cluster: Isoform b of Q10656 ; n=4;
Caenorhabditis|Rep: Isoform b of Q10656 - Caenorhabditis
elegans
Length = 988
Score = 173 bits (420), Expect = 3e-41
Identities = 72/160 (45%), Positives = 113/160 (70%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
LT HL+ +A+Q+A+GM +LA++K++H DLAARNVL+ D +V+KI DFGL+R ++ N+ Y
Sbjct: 717 LTQRHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLVGDGHVLKISDFGLSRDVHCNDYY 776
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
+K+ N LP+KW+A+E + +++ +SDVWSYG++LWE+ +L TPYP I+ +L L
Sbjct: 777 RKRGNGRLPIKWMALEALDSNVYTVESDVWSYGVLLWEIMTLGGTPYPTIAMPELYANLK 836
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEIL 956
+G R+E P +Y++M CW +K RPSF + + L
Sbjct: 837 EGYRMEPPHLCPQEVYHLMCSCWREKLEERPSFKTIVDYL 876
Score = 77.4 bits (182), Expect = 2e-12
Identities = 42/111 (37%), Positives = 64/111 (57%), Gaps = 5/111 (4%)
Query: 599 DEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALA 658
D +E R KL+ LG GAFG V+KA + N E+ VAVK +K +A + L
Sbjct: 578 DPVWEVERSKLSLVHMLGEGAFGEVWKATYKETENNEIA--VAVKKLKMSAHEKELIDLV 635
Query: 659 SELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
SE++ +G+H N++ L+G CT L V+VE CK+GN+ ++++ HR
Sbjct: 636 SEMETFKVIGEHENVLRLIGCCT---GAGPLYVVVELCKHGNLRDFLRAHR 683
Score = 48.4 bits (110), Expect = 0.001
Identities = 22/89 (24%), Positives = 45/89 (50%), Gaps = 3/89 (3%)
Query: 441 NKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIE 500
N+ GR+++L+C A+G P P I WYK+ +++ +S + + E+E
Sbjct: 247 NETHALPAGRTLKLNCRAKGYPEPQIIWYKNGKMLKKSSARSGGYEF---KFNRWSLEVE 303
Query: 501 NMQEKDNGIYECVALNNASELRRAYTLVL 529
+ D+G + C ALN ++ + +++
Sbjct: 304 DAVVADSGEFHCEALNKVGSAKKYFHVII 332
>UniRef50_Q4RXB0 Cluster: Chromosome 11 SCAF14979, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 11 SCAF14979, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 1078
Score = 173 bits (420), Expect = 3e-41
Identities = 78/184 (42%), Positives = 117/184 (63%), Gaps = 2/184 (1%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P+ T L+G+ Q+A+GMEYLA +K +H DLAARN +L + VK+ DFG+AR +Y+
Sbjct: 863 PQNPTVKDLIGFGLQVAKGMEYLAQKKFVHRDLAARNCMLDETYTVKVADFGMARDIYDK 922
Query: 854 EEY--QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDL 911
E Y Q + LPVKW+A+E + + F+ +SDVWSYGI++WE+ + +PYP++ P D+
Sbjct: 923 EYYSIQDHKQVKLPVKWMALESLQTQKFTIKSDVWSYGILMWELLTRGASPYPDVDPYDI 982
Query: 912 LRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDL 971
+L G RL +P F D LY++ML CW +P RPSF+ L + + L + Y++L
Sbjct: 983 THYLLKGRRLPQPQFCPDTLYSIMLSCWDPEPDYRPSFSSLTADVQHILLCLQGEHYINL 1042
Query: 972 NAPY 975
Y
Sbjct: 1043 KVHY 1046
>UniRef50_Q4RKW3 Cluster: Tyrosine-protein kinase receptor; n=1;
Tetraodon nigroviridis|Rep: Tyrosine-protein kinase
receptor - Tetraodon nigroviridis (Green puffer)
Length = 1328
Score = 173 bits (420), Expect = 3e-41
Identities = 85/191 (44%), Positives = 124/191 (64%), Gaps = 26/191 (13%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
LT L+ ++FQ+A+GME+L++RK +H DLAARN+LL++++VVKICDFGLAR +Y + +Y
Sbjct: 981 LTMEDLIRYSFQVAKGMEFLSSRKCIHRDLAARNILLSENSVVKICDFGLARDVYKDPDY 1040
Query: 857 QKK-------------------ENSPL------PVKWLAIECMVDRIFSTQSDVWSYGIV 891
+K +SPL P+KW+A E + DR+++TQSDVWS+G++
Sbjct: 1041 VRKGDVSLSRRSITRSSSTGVTRDSPLSLQARLPLKWMAPETIFDRVYTTQSDVWSFGVL 1100
Query: 892 LWEMFSLAKTPYPNIS-PTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFT 950
LWE+FSL +PYP + R L +G R+ P +A +Y +ML CW +PT RP+F
Sbjct: 1101 LWEIFSLGASPYPGVCIDESFCRRLKEGTRMRPPEYAPTEIYQIMLDCWLDRPTDRPTFA 1160
Query: 951 ELQEILGNFLE 961
EL E LGN L+
Sbjct: 1161 ELVEHLGNLLQ 1171
Score = 131 bits (316), Expect = 1e-28
Identities = 90/279 (32%), Positives = 136/279 (48%), Gaps = 32/279 (11%)
Query: 452 IQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIYE 511
+ LHC+A G P PT+ W K+++ + SG L + N T I+ ++ +D+G Y
Sbjct: 645 VTLHCDAAGRPSPTVLWTKNNQTVVEGSGVILSRN-------NQTLTIQRVKREDSGHYI 697
Query: 512 CVALNNASELRRAYTLVLKAEKSYTPYXXXXXXXXXXXXGMVAYLFTWK----------- 560
C A N L + ++ + Y ++ F+
Sbjct: 698 CTACNRRGCDSSQAFLTTEGQQIKSHYFTQILSFSLSLSLSLSLSFSLSHTHTHTHTHTH 757
Query: 561 LKKQRELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFE----------FPREKLT 610
+ L G+ K+ ++ +D + +P DE+ E FPR++L
Sbjct: 758 THTHTHTSSTFLSQTNGGDLKTGYLSMILDSED--MPMDEQCERLTYDANKWEFPRDRLK 815
Query: 611 FGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKH 670
G LG GAFG V +A A GI A T VAVKM+K A + +AL SELKI++H+G H
Sbjct: 816 LGDPLGRGAFGQVVEAAAFGIEKATTCTTVAVKMLKEGATSSEFRALMSELKILIHIGHH 875
Query: 671 VNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+N+VNLLGACTK L+VIVEYCK+GN+ +Y++ R
Sbjct: 876 LNVVNLLGACTK--PGGPLMVIVEYCKHGNLSSYLKTKR 912
Score = 66.1 bits (154), Expect = 5e-09
Identities = 79/345 (22%), Positives = 138/345 (40%), Gaps = 29/345 (8%)
Query: 3 EIVVPRDCSKIVIECRPTTPDVNVTLSSEIPDY-YYPSFR---YSPKIGFVPENSMPSDD 58
E+V R+ +VI CR + D+NVTL ++ P+ YP + + + GF+ + + S
Sbjct: 93 EVVFIREGEWVVIPCRSSVEDLNVTLHTKYPNKELYPDGKETVWDARKGFMVPSHLIS-- 150
Query: 59 QIISFVLCEFVRGETRIEKYIYVSKHIK-KPPKPKVAGGHKQFLEGETFTIHCRVP---N 114
V C+ G + +Y+ + K + Q GE + C N
Sbjct: 151 -YAGVVFCQTQIGNETFKSPLYIVAVVGYKIYDLTLTPAKTQLAAGERLVLSCTAITELN 209
Query: 115 DGLINFKWKYPPEV---TNDSVEVSVVKTEATTTGSIVYQN-ITIRNATKKHNGVYTCLL 170
G I F W + + N S + S+ N +T+ N T H+G YTC
Sbjct: 210 VG-IEFNWTHSGQALASVNSSRPTYATPHKKKLWNSLELSNTLTVENVTVDHSGEYTCSA 268
Query: 171 TNTCGEEKDEFRKIFLEKPFLSLRD-LAKGKLMGNANKSINIVIEIEAYPPVERTHFLKN 229
++ E+ + EKPF+ +++ AK + ++ I ++ AYP +LKN
Sbjct: 269 SSGLMEKSESVPVKVYEKPFIEIKEPWAKVLEVNVGDQLTTIPVKYSAYPE-PGYKWLKN 327
Query: 230 DKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPE 289
+ L D ++ L N L I + TD YT+V NK + L++
Sbjct: 328 GQPL-KEDYRFR-QKLDN----LVIRGVTETDAGLYTVVLTNKITKEEQRRSLQLLVNVP 381
Query: 290 AKLLNNRIIKRLE----NSEMNFACKVTGYPLPD-VTWIFSNDEE 329
++ + + S C G+P+P + W + E+
Sbjct: 382 PHIIEKEVAADTDVYPYGSSPTLRCTARGFPIPSHIEWQWMAKED 426
>UniRef50_Q10656 Cluster: Myoblast growth factor receptor egl-15
precursor; n=7; Caenorhabditis elegans|Rep: Myoblast
growth factor receptor egl-15 precursor - Caenorhabditis
elegans
Length = 1040
Score = 173 bits (420), Expect = 3e-41
Identities = 72/160 (45%), Positives = 113/160 (70%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
LT HL+ +A+Q+A+GM +LA++K++H DLAARNVL+ D +V+KI DFGL+R ++ N+ Y
Sbjct: 769 LTQRHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLVGDGHVLKISDFGLSRDVHCNDYY 828
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
+K+ N LP+KW+A+E + +++ +SDVWSYG++LWE+ +L TPYP I+ +L L
Sbjct: 829 RKRGNGRLPIKWMALEALDSNVYTVESDVWSYGVLLWEIMTLGGTPYPTIAMPELYANLK 888
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEIL 956
+G R+E P +Y++M CW +K RPSF + + L
Sbjct: 889 EGYRMEPPHLCPQEVYHLMCSCWREKLEERPSFKTIVDYL 928
Score = 77.4 bits (182), Expect = 2e-12
Identities = 42/111 (37%), Positives = 64/111 (57%), Gaps = 5/111 (4%)
Query: 599 DEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALA 658
D +E R KL+ LG GAFG V+KA + N E+ VAVK +K +A + L
Sbjct: 630 DPVWEVERSKLSLVHMLGEGAFGEVWKATYKETENNEIA--VAVKKLKMSAHEKELIDLV 687
Query: 659 SELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
SE++ +G+H N++ L+G CT L V+VE CK+GN+ ++++ HR
Sbjct: 688 SEMETFKVIGEHENVLRLIGCCT---GAGPLYVVVELCKHGNLRDFLRAHR 735
Score = 48.4 bits (110), Expect = 0.001
Identities = 22/89 (24%), Positives = 45/89 (50%), Gaps = 3/89 (3%)
Query: 441 NKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIE 500
N+ GR+++L+C A+G P P I WYK+ +++ +S + + E+E
Sbjct: 299 NETHALPAGRTLKLNCRAKGYPEPQIIWYKNGKMLKKSSARSGGYEF---KFNRWSLEVE 355
Query: 501 NMQEKDNGIYECVALNNASELRRAYTLVL 529
+ D+G + C ALN ++ + +++
Sbjct: 356 DAVVADSGEFHCEALNKVGSAKKYFHVII 384
>UniRef50_UPI00015B51DA Cluster: PREDICTED: similar to
ENSANGP00000013218; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000013218 - Nasonia
vitripennis
Length = 972
Score = 172 bits (418), Expect = 5e-41
Identities = 84/198 (42%), Positives = 120/198 (60%), Gaps = 3/198 (1%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
+T +L +A+QI++GM YLA+ K++H DLAARNVLL V KI DFGL R +Y ++ Y
Sbjct: 616 ITPRDILSFAWQISKGMAYLADIKLVHRDLAARNVLLGAGKVCKISDFGLTRDVYEDDAY 675
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
K+ +PVKW+A E + D +++++SDVWS+G++LWE+ +L +PYP + +L L
Sbjct: 676 LKRSKGRVPVKWMAPESLADHVYTSKSDVWSFGVLLWELVTLGASPYPGVDVHNLYNLLK 735
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLNAPYN 976
G R+EKP +LY +M+ CWH +P RPSF EL LED Y+DLN P
Sbjct: 736 AGYRMEKPANCSHQLYKLMVSCWHDEPGMRPSFKELTCHWERMLED--AVEYLDLN-PRT 792
Query: 977 EMNAELMTGEDYLAMVCA 994
N T L C+
Sbjct: 793 VHNQAYFTSLHALDSPCS 810
Score = 81.4 bits (192), Expect = 1e-13
Identities = 42/115 (36%), Positives = 70/115 (60%), Gaps = 3/115 (2%)
Query: 597 PYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKA 656
P D K+EFPR +L+ + LG G FG V +A+A+ I + T VAVK +K A +
Sbjct: 489 PPDPKWEFPRSRLSIEQVLGEGEFGRVLRAKAQDIAGWQGQTTVAVKTLKEDASASELAD 548
Query: 657 LASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREV 711
L SE +++ +H N++ LLGACT A + +I+E+ ++G++ NY+++ R +
Sbjct: 549 LLSEYQLLKE-AQHPNVIRLLGACT--TAGGPIYLIIEFAEFGSLRNYLRRSRHL 600
>UniRef50_A7RVU0 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 337
Score = 172 bits (418), Expect = 5e-41
Identities = 75/158 (47%), Positives = 109/158 (68%)
Query: 806 AFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLP 865
++Q++RG+E+LA+RK +H DLAARNVL+ D V+K+ DFGLAR +Y ++ Y K + LP
Sbjct: 166 SYQVSRGVEFLASRKCVHRDLAARNVLVGPDYVMKVSDFGLARDIYQDDLYVKNTSGLLP 225
Query: 866 VKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPP 925
VKW+A+E + DR+++ +SDVWS+GI+LWE+ +L TPYP + LL +LS+G R+ +P
Sbjct: 226 VKWMALESLFDRVYTEKSDVWSFGILLWEIMTLGGTPYPGLPTEQLLDYLSEGQRMAQPQ 285
Query: 926 FADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
+Y +M CW Q P RP F L + LG LE N
Sbjct: 286 NCPLEIYTIMRDCWMQLPEQRPHFNVLADRLGKVLERN 323
Score = 108 bits (259), Expect = 1e-21
Identities = 65/153 (42%), Positives = 92/153 (60%), Gaps = 16/153 (10%)
Query: 584 NPNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVK 643
+P+ + EQ + LPYD +EFP E+L GK LG GAFG V +AEA G+ N A
Sbjct: 7 DPDRSLLEQCNNLPYDLDWEFPEERLILGKVLGQGAFGQVLRAEAIGMDNFNPRDKSADG 66
Query: 644 MVKRT----------ADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIV 693
+ R+ A K LASELKI++HLG+H NIVN+LGACT+ R L+VI+
Sbjct: 67 LKTRSKMRRSLRGKGASESDYKDLASELKILIHLGEHKNIVNVLGACTR---GRRLMVII 123
Query: 694 EYCKYGNIHNYMQKHREVF---IDQLTDNAEKN 723
E+ YGN+ ++++ REV+ + T++ EKN
Sbjct: 124 EFAPYGNLLSFLRARREVYQPTWTKTTNDPEKN 156
>UniRef50_UPI00015B4DC3 Cluster: PREDICTED: similar to receptor
tyrosine kinase Torso-like protein; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to receptor tyrosine
kinase Torso-like protein - Nasonia vitripennis
Length = 590
Score = 171 bits (417), Expect = 7e-41
Identities = 73/171 (42%), Positives = 114/171 (66%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
LL +A Q+A GME+L++ +++H DLAARNVL+ D VKI DFGL+R +Y Y+K+ N
Sbjct: 390 LLNFARQVASGMEFLSSNRIVHRDLAARNVLVCADQTVKISDFGLSRDIYQENVYKKQTN 449
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
LP+KW+AIE + ++++T SDVWS+G++L+E+ +L PYP + ++L +L G R+
Sbjct: 450 GKLPIKWMAIEALTHQVYTTHSDVWSFGVLLYEIVTLGGNPYPGLPCCEVLHFLKSGYRM 509
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLN 972
E+P +LY +M CWH+ P RP+F L++ L L N Y++L+
Sbjct: 510 ERPSNCGFQLYEIMRSCWHENPLNRPTFYNLKQQLDKLLTTFTGNEYLNLS 560
Score = 62.9 bits (146), Expect = 5e-08
Identities = 36/107 (33%), Positives = 63/107 (58%), Gaps = 5/107 (4%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+KFE ++L+ K LG+G GVV A + + + VAVKM++ A + ++
Sbjct: 229 DKFEIQVDRLSIKKILGSGISGVVKLATLQD--DKKKIIQVAVKMLREDASSDDVQNFHR 286
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
E+ +M G H NIV+++G CT ++K+ L+V VE+C G++ Y++
Sbjct: 287 EIALMKSAGNHPNIVSIIGCCT--LSKQPLLV-VEFCSKGDLQTYLR 330
>UniRef50_Q9YGM5 Cluster: Plasminogen related growth factor receptor
2; n=11; Clupeocephala|Rep: Plasminogen related growth
factor receptor 2 - Fugu rubripes (Japanese pufferfish)
(Takifugu rubripes)
Length = 1375
Score = 171 bits (417), Expect = 7e-41
Identities = 78/185 (42%), Positives = 117/185 (63%), Gaps = 2/185 (1%)
Query: 793 QPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYN 852
+ R T L+G+ Q+A+GMEYLA +K +H DLAARN +L + VK+ DFG+AR +Y+
Sbjct: 1159 EKRNPTVKDLIGFGLQVAKGMEYLAQKKFVHRDLAARNCMLDETYTVKVADFGMARDIYD 1218
Query: 853 NEEY--QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTD 910
E Y Q + LPVKW+AIE + + F+++SDVWSYGI++WE+ + +PYP++ P D
Sbjct: 1219 KEYYSIQDHKQVKLPVKWMAIESLQTQKFTSKSDVWSYGILMWELLTRGASPYPDVDPYD 1278
Query: 911 LLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVD 970
+ +L G RL +P F + LY++ML CW +P RPSF+ L + + L + Y+
Sbjct: 1279 ITNYLLKGRRLPQPQFCPNTLYSIMLSCWDPEPDFRPSFSSLASDVQHILLCLQGEHYIS 1338
Query: 971 LNAPY 975
L Y
Sbjct: 1339 LKVNY 1343
>UniRef50_A7RHT9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 295
Score = 171 bits (415), Expect = 1e-40
Identities = 74/169 (43%), Positives = 112/169 (66%), Gaps = 1/169 (0%)
Query: 795 RPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNE 854
+ LT+ LL + Q ARGM +LA+ KV+H DLAARN+L+ + +V K+ DFG AR +Y +
Sbjct: 122 KKLTAKDLLSFGIQAARGMAHLASMKVVHRDLAARNILIDEKSVCKVSDFGFARDIYVED 181
Query: 855 EYQKK-ENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
Y +K + P+KW+AIE ++D + +T+SDVWSYG++LWE+ +L +PYP ++ +++
Sbjct: 182 HYTRKTQGGRFPIKWMAIESLLDGVSTTKSDVWSYGVLLWEIVTLGASPYPGMNSQEVIN 241
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLED 962
+L DG R++KP D LY VML CW RP+F E+ +L L D
Sbjct: 242 FLQDGYRMDKPKHCLDELYAVMLDCWQLSAQRRPTFVEISRLLNKMLSD 290
Score = 89.8 bits (213), Expect = 4e-16
Identities = 48/127 (37%), Positives = 79/127 (62%), Gaps = 6/127 (4%)
Query: 601 KFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASE 660
++EFPR+++ LG+GAFGVV KA+A+GI + PVAVK+VK + + L +E
Sbjct: 1 RWEFPRDRVKTSVVLGSGAFGVVMKADAQGIKGCVGSLPVAVKIVKENDSDTARRDLMAE 60
Query: 661 LKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREV---FIDQLT 717
L ++ + H N++ LLG CT+ L+VIVE+C+YG++ +Y++ R + + +Q+
Sbjct: 61 LDLLKLIDPHPNVIGLLGCCTR---GDPLMVIVEFCQYGDLQSYLRHCRGIEDKYYEQIY 117
Query: 718 DNAEKNL 724
EK L
Sbjct: 118 MVPEKKL 124
>UniRef50_Q6DTW4 Cluster: Tyrosine kinase receptor ron; n=6;
Eumetazoa|Rep: Tyrosine kinase receptor ron - Canis
familiaris (Dog)
Length = 998
Score = 169 bits (412), Expect = 3e-40
Identities = 84/199 (42%), Positives = 122/199 (61%), Gaps = 3/199 (1%)
Query: 785 GDYIYECHQP-RPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
GD + P R T L+ + Q+ARGMEYLA +K +H DLAARN +L + VK+ D
Sbjct: 765 GDLLRFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVAD 824
Query: 844 FGLARSMYNNEEYQKKEN--SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKT 901
FGLAR + + E Y +++ + LPVKW+A+E + F+T+SDVWS+G++LWE+ +
Sbjct: 825 FGLARDILDKEYYSVRQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAP 884
Query: 902 PYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
PYP+I P DL+++L+ G RL +P + + LY VM RCW P RP+FT L E + +
Sbjct: 885 PYPHIDPFDLIQFLAQGRRLPQPEYCPNSLYMVMQRCWAVDPAVRPTFTALVEEVEHVAA 944
Query: 962 DNERNRYVDLNAPYNEMNA 980
+ YV L A Y + A
Sbjct: 945 RLLGDHYVQLPAAYVNLGA 963
>UniRef50_Q5DM52 Cluster: Receptor tyrosine kinase Torso-like
protein; n=1; Tribolium castaneum|Rep: Receptor tyrosine
kinase Torso-like protein - Tribolium castaneum (Red
flour beetle)
Length = 803
Score = 169 bits (410), Expect = 5e-40
Identities = 76/162 (46%), Positives = 109/162 (67%)
Query: 801 HLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKE 860
HLL A Q+A GME+LA +V+H DLAARNVL+ +++ VK+ DFGL+R +Y + Y K
Sbjct: 593 HLLSIARQVALGMEHLAKTRVVHRDLAARNVLVCENHTVKVSDFGLSRDVYQDNVYCKNG 652
Query: 861 NSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNR 920
LPV+W+A+E + + ++T SDVWS+G++LWE+ +L TPY + ++LL +L GNR
Sbjct: 653 GGKLPVRWMALESLTHQRYTTYSDVWSFGVLLWEIVTLGGTPYVGVHSSELLDFLKSGNR 712
Query: 921 LEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLED 962
L +P LY VML CW + P RP+FTEL + L LE+
Sbjct: 713 LARPANCSPDLYAVMLNCWKECPKNRPTFTELSKSLEGLLEN 754
Score = 64.1 bits (149), Expect = 2e-08
Identities = 41/124 (33%), Positives = 70/124 (56%), Gaps = 5/124 (4%)
Query: 585 PNLGIDEQADLLPYD--EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAV 642
P G + + +L+ D +++E KL+F +G GAFG+V +A + + T VAV
Sbjct: 425 PESGENIEINLIKPDIFDQWELGPLKLSFQGVIGEGAFGIVRRAFLD--LKEDNKTQVAV 482
Query: 643 KMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIH 702
KM+K + + I+ E+ IM + +H IV+L+G T+ A+ L+V VEYC G++
Sbjct: 483 KMLKESPTSEEIRQFTQEINIMKSVRQHPYIVSLIGCVTEGRAEGPLLV-VEYCSRGDLQ 541
Query: 703 NYMQ 706
Y++
Sbjct: 542 TYLR 545
>UniRef50_UPI0000D57494 Cluster: PREDICTED: similar to insulin
receptor; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to insulin receptor - Tribolium castaneum
Length = 1351
Score = 168 bits (408), Expect = 9e-40
Identities = 76/162 (46%), Positives = 108/162 (66%)
Query: 795 RPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNE 854
+P T +L A +IA GM YL+ +K +H DLAARN ++A+D VKI DFG+ R +Y +
Sbjct: 1088 QPPTLKQILQMAIEIADGMAYLSAKKFVHRDLAARNCMVAEDLTVKIGDFGMTRDIYETD 1147
Query: 855 EYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRW 914
Y+K LPV+W+A E + D +F++ SDVWSYG+VLWEM +LA PY +S +LR+
Sbjct: 1148 YYRKGTKGLLPVRWMAPESLKDGVFTSNSDVWSYGVVLWEMATLASQPYQGLSNDQVLRY 1207
Query: 915 LSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEIL 956
+ DG +E+P D+LY +M CW KP+ARPSF +L +L
Sbjct: 1208 VIDGGVMERPENCPDKLYTLMRYCWQHKPSARPSFLKLCSLL 1249
Score = 50.0 bits (114), Expect = 4e-04
Identities = 31/110 (28%), Positives = 57/110 (51%), Gaps = 5/110 (4%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+++E PR+K+ ++LG G+FG+VY+ A+ + + AVK V A N +
Sbjct: 971 DEWEVPRKKIELIRELGQGSFGMVYEGIAQD-VRGKAQIKCAVKTVNEHATNRERLEFLN 1029
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
E +M ++V LLG ++ + +VI+E G++ Y++ HR
Sbjct: 1030 EASVMKAFDT-AHVVRLLGVVSQ---GQPTLVIMELMANGDLKTYLRSHR 1075
>UniRef50_Q8INU0 Cluster: CG14396-PD, isoform D; n=10; Sophophora|Rep:
CG14396-PD, isoform D - Drosophila melanogaster (Fruit
fly)
Length = 1237
Score = 168 bits (408), Expect = 9e-40
Identities = 76/192 (39%), Positives = 120/192 (62%), Gaps = 4/192 (2%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
P+ +L +A+QI +GM YL+ K++H DLAARNVLLAD + KI DFGL R +Y ++
Sbjct: 884 PVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDA 943
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
Y K+ +PVKW+A E + D +++++SDVWS+G++ WE+ +L +PYP I+P +L L
Sbjct: 944 YLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLL 1003
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLNAPY 975
G R+++P + +Y+++ CW +P RPSF L L +N +Y+DL
Sbjct: 1004 KTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNNA--KYIDLET-- 1059
Query: 976 NEMNAELMTGED 987
N ++ L G+D
Sbjct: 1060 NAVSNPLYCGDD 1071
Score = 85.4 bits (202), Expect = 8e-15
Identities = 45/113 (39%), Positives = 69/113 (61%), Gaps = 4/113 (3%)
Query: 599 DEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALA 658
D K+EFPREKL LG G FG V K A I T VAVKM+K+ ++++ AL
Sbjct: 763 DAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALL 822
Query: 659 SELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREV 711
SE +++ + H N++ LLGACT A ++I+EY +YG++ +Y++ R++
Sbjct: 823 SEFQLLQEV-SHPNVIKLLGACTSSEAP---LLIIEYARYGSLRSYLRLSRKI 871
>UniRef50_UPI00015B4CAE Cluster: PREDICTED: similar to
ENSANGP00000019144; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000019144 - Nasonia
vitripennis
Length = 1220
Score = 167 bits (406), Expect = 2e-39
Identities = 75/179 (41%), Positives = 117/179 (65%), Gaps = 2/179 (1%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
LTS L + + +ARGMEYLA++K++H DLAARNVL+ + + KI DFG++R + E
Sbjct: 1035 LTSRDLTVFGYCVARGMEYLASKKIIHRDLAARNVLVDHNKLCKIADFGMSRFANEDGEV 1094
Query: 857 QKKEN--SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRW 914
+ + + LP++W+A E ++ +F+T++DVWS+GI++WE+ +L TPYP+++ +++R
Sbjct: 1095 IETRHGRNALPIRWMAPESLIYSLFTTKTDVWSFGILMWEIVTLGSTPYPDMTAREVMRS 1154
Query: 915 LSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLNA 973
+ G RLE+P L+ V+ RCWH P RP F L+ L LEDN YVDL +
Sbjct: 1155 VQSGYRLERPSHCRSELFRVIARCWHADPDRRPEFQLLRRDLAQLLEDNMNGHYVDLES 1213
Score = 83.4 bits (197), Expect = 3e-14
Identities = 47/112 (41%), Positives = 66/112 (58%), Gaps = 4/112 (3%)
Query: 599 DEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTP-VAVKMVKRTADNMYIKAL 657
+ ++EFPR+KL LG G FG V+KAEA + + TT VAVK VK A + + L
Sbjct: 912 ESRWEFPRDKLRLQTVLGEGNFGQVWKAEADDLTGHQGTTRLVAVKTVKEGASDREKEDL 971
Query: 658 ASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
EL+IM +G H N+V LLG CT+ + +I+EY YG + Y++ HR
Sbjct: 972 VRELEIMQRVGSHPNVVTLLGCCTE---QEPHYLILEYVMYGKLLAYLRDHR 1020
>UniRef50_P18475 Cluster: Tyrosine-protein kinase receptor torso
precursor; n=2; Sophophora|Rep: Tyrosine-protein kinase
receptor torso precursor - Drosophila melanogaster
(Fruit fly)
Length = 923
Score = 167 bits (406), Expect = 2e-39
Identities = 76/170 (44%), Positives = 118/170 (69%), Gaps = 2/170 (1%)
Query: 793 QPR-PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMY 851
+PR PL LL A Q+A GME+LA KV+H DLAARNVL++ D +KI DFGL+R +Y
Sbjct: 708 KPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLISVDRSIKIADFGLSRDVY 767
Query: 852 NNEEYQKKENS-PLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTD 910
+ Y+K S LP+KWLA+E + +++++QSDVWS+G++L+E+ +L PYP++SP+D
Sbjct: 768 HENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLGGMPYPSVSPSD 827
Query: 911 LLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFL 960
LL+ L G+R+++P ++++M CW P+ RP+F+ L+ LG +
Sbjct: 828 LLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRLGGMI 877
Score = 57.6 bits (133), Expect = 2e-06
Identities = 33/110 (30%), Positives = 63/110 (57%), Gaps = 9/110 (8%)
Query: 615 LGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIV 674
LG GAFG+V RG+ VAVK++K ++ + A E++++ +GKH NIV
Sbjct: 481 LGEGAFGLV----RRGVYKKR---QVAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIV 533
Query: 675 NLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDNAEKNL 724
++G T+ ++++++EYC G++ N++++ + +Q +KNL
Sbjct: 534 GIVGYSTRF--SNQMMLLIEYCSLGSLQNFLREEWKFRQEQNAIGLKKNL 581
>UniRef50_P23049 Cluster: Tyrosine-protein kinase transforming
protein SEA; n=6; root|Rep: Tyrosine-protein kinase
transforming protein SEA - Avian erythroblastosis virus
(strain S13)
Length = 370
Score = 167 bits (405), Expect = 2e-39
Identities = 78/185 (42%), Positives = 114/185 (61%), Gaps = 2/185 (1%)
Query: 793 QPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYN 852
Q R T L+G+ Q+A GMEYLA +K +H DLAARN +L + VK+ DFGLAR ++
Sbjct: 154 QERSPTVKELIGFGLQVALGMEYLAQKKFVHRDLAARNCMLDETLTVKVADFGLARDVFG 213
Query: 853 NEEYQKKEN--SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTD 910
E Y +++ + LPV+W+A+E + + F+T+SDVWS+G+++WE+ + +PYP + P D
Sbjct: 214 KEYYSIRQHRHAKLPVRWMALESLQTQKFTTKSDVWSFGVLMWELLTRGASPYPEVDPYD 273
Query: 911 LLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVD 970
+ R+L G RL +P D LY VML CW P RPSF+ L L L E Y++
Sbjct: 274 MARYLLRGRRLPQPQPCPDTLYGVMLSCWAPTPEERPSFSGLVCELERVLASLEGEHYIN 333
Query: 971 LNAPY 975
+ Y
Sbjct: 334 MAVTY 338
>UniRef50_P30530 Cluster: Tyrosine-protein kinase receptor UFO
precursor; n=37; Euteleostomi|Rep: Tyrosine-protein
kinase receptor UFO precursor - Homo sapiens (Human)
Length = 887
Score = 166 bits (404), Expect = 3e-39
Identities = 73/169 (43%), Positives = 115/169 (68%)
Query: 793 QPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYN 852
QP L + L+ + IA GMEYL+ ++ +H DLAARN +L ++ V + DFGL++ +YN
Sbjct: 633 QPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYN 692
Query: 853 NEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLL 912
+ Y++ + +PVKW+AIE + DR+++++SDVWS+G+ +WE+ + +TPYP + +++
Sbjct: 693 GDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIY 752
Query: 913 RWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
+L GNRL++P D LY +M RCW P RPSFTEL+E L N L+
Sbjct: 753 DYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLK 801
Score = 42.3 bits (95), Expect = 0.074
Identities = 33/124 (26%), Positives = 58/124 (46%), Gaps = 10/124 (8%)
Query: 586 NLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMV 645
+LGI E+ D + R K+ GK LG G FG V + + + + VAVK +
Sbjct: 508 SLGISEELKEKLRDVMVD--RHKVALGKTLGEGEFGAVMEGQ---LNQDDSILKVAVKTM 562
Query: 646 K-RTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKREL---IVIVEYCKYGNI 701
K ++ SE M H N++ L+G C + + +VI+ + K+G++
Sbjct: 563 KIAICTRSELEDFLSEAVCMKEF-DHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDL 621
Query: 702 HNYM 705
H+++
Sbjct: 622 HSFL 625
>UniRef50_Q7YT64 Cluster: Tyrosine-protein kinase receptor; n=1;
Crassostrea gigas|Rep: Tyrosine-protein kinase receptor
- Crassostrea gigas (Pacific oyster) (Crassostrea
angulata)
Length = 804
Score = 166 bits (403), Expect = 4e-39
Identities = 77/172 (44%), Positives = 114/172 (66%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
P T ++ A +IA GM YLA++K +H DLAARN ++A+D VKI DFG+ R +Y +
Sbjct: 452 PPTIKRIIQMAGEIADGMAYLADKKFVHRDLAARNCMVAEDLTVKIADFGMTRDIYETDY 511
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
Y+K + LPV+W+A E + D IF++ SDVWSYG+VLWEM +LA PY +S ++LR++
Sbjct: 512 YRKGGKALLPVRWMAPESLKDGIFTSLSDVWSYGVVLWEMATLAAQPYQGLSNEEVLRYV 571
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNR 967
+G +EKP DRL+ +M +CW +P RP+F E+ E L L+ + N+
Sbjct: 572 LNGRVMEKPEDCPDRLFELMQKCWRYRPKQRPTFKEILEELVPELDPSFANK 623
Score = 48.4 bits (110), Expect = 0.001
Identities = 32/112 (28%), Positives = 57/112 (50%), Gaps = 4/112 (3%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+++E R+K+ ++LG G+FG+VY+ AR + VAVK V A S
Sbjct: 326 DEWEVERDKIQLIRELGQGSFGMVYEGVARDLYGKGGEIKVAVKTVNEHATYRERMEFLS 385
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREV 711
E M + ++V LLG + + ++I+E + G++ N+++ HR V
Sbjct: 386 EASRMKAFSCN-HVVRLLGVVSD---GQPALLIMELMEKGDLKNFLRMHRPV 433
>UniRef50_Q02763 Cluster: Angiopoietin-1 receptor precursor; n=41;
Euteleostomi|Rep: Angiopoietin-1 receptor precursor -
Homo sapiens (Human)
Length = 1124
Score = 166 bits (403), Expect = 4e-39
Identities = 81/174 (46%), Positives = 114/174 (65%), Gaps = 5/174 (2%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
L+S LL +A +ARGM+YL+ ++ +H DLAARN+L+ ++ V KI DFGL+R E Y
Sbjct: 936 LSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ---EVY 992
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
KK LPV+W+AIE + +++T SDVWSYG++LWE+ SL TPY ++ +L L
Sbjct: 993 VKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLP 1052
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVD 970
G RLEKP DD +Y++M +CW +KP RPSF ++ L LE ER YV+
Sbjct: 1053 QGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLE--ERKTYVN 1104
Score = 57.6 bits (133), Expect = 2e-06
Identities = 35/106 (33%), Positives = 57/106 (53%), Gaps = 6/106 (5%)
Query: 609 LTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLG 668
+ F +G G FG V KA + + A+K +K A + A EL+++ LG
Sbjct: 824 IKFQDVIGEGNFGQVLKARIK---KDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLG 880
Query: 669 KHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFID 714
H NI+NLLGAC +H + L + +EY +GN+ ++++K R + D
Sbjct: 881 HHPNIINLLGAC-EH--RGYLYLAIEYAPHGNLLDFLRKSRVLETD 923
>UniRef50_Q93105 Cluster: Insulin-like receptor precursor (EC
2.7.10.1) (MIR) [Contains: Insulin-like receptor alpha
chain; Insulin-like receptor beta chain]; n=2; Aedes
aegypti|Rep: Insulin-like receptor precursor (EC
2.7.10.1) (MIR) [Contains: Insulin-like receptor alpha
chain; Insulin-like receptor beta chain] - Aedes aegypti
(Yellowfever mosquito)
Length = 1390
Score = 165 bits (401), Expect = 6e-39
Identities = 85/212 (40%), Positives = 129/212 (60%), Gaps = 6/212 (2%)
Query: 782 KYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKI 841
++ DY +P T ++ A +IA G+ L+ +K +H DLAARN ++ADD VKI
Sbjct: 1119 RHRPDYEMRRSIRQPPTLRQIIQMAIEIADGIGVLSAKKFVHRDLAARNCMVADDMTVKI 1178
Query: 842 CDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKT 901
DFG+ R +Y + Y+K LPV+W+A E + D IFS+ SDV+SYG+VLWEM +LA
Sbjct: 1179 GDFGMTRDIYETDYYRKGTKGFLPVRWMAPESLKDGIFSSSSDVFSYGVVLWEMATLASQ 1238
Query: 902 PYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
PY ++ +LR++ DG +E+P D LYN+M RCW +PTARP+F EI+ L
Sbjct: 1239 PYQGLTNDQVLRYVIDGGVMERPENCPDNLYNLMRRCWQHRPTARPTF---MEIISELLP 1295
Query: 962 DNERNRYVDLNAPYNEMNA-ELMTGEDYLAMV 992
D + + D+ A YN +A +++ G+ ++
Sbjct: 1296 DASPH-FQDV-AFYNSQDALDMLRGQHQTVII 1325
Score = 47.6 bits (108), Expect = 0.002
Identities = 29/110 (26%), Positives = 54/110 (49%), Gaps = 4/110 (3%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+ +E R + ++LG G+FG+VYK + + P A+K V +A +
Sbjct: 1016 DDWEVERNHIIQLEELGQGSFGMVYKGILTQLRGEKCNQPCAIKTVNESATAREKDSFLL 1075
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
E +M H ++V LLG ++ +VI+E G++ +Y+++HR
Sbjct: 1076 EASVMKQFNTH-HVVRLLGVVSQ---GDPTLVIMELMANGDLKSYLRRHR 1121
>UniRef50_UPI00004D7E5F Cluster: Proto-oncogene tyrosine-protein
kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor
tyrosine kinase MerTK).; n=1; Xenopus tropicalis|Rep:
Proto-oncogene tyrosine-protein kinase MER precursor (EC
2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK). -
Xenopus tropicalis
Length = 763
Score = 165 bits (400), Expect = 8e-39
Identities = 71/160 (44%), Positives = 108/160 (67%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ + IA GMEYL++R LH DLAARN +L DD V + DFGL++ +Y+ + Y++
Sbjct: 584 LVKFMIDIATGMEYLSSRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRI 643
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
+ +PVKW+A+E + DRI++ +SDVW++G+ +WE+ + TPYP + ++ +L G+RL
Sbjct: 644 AKMPVKWIAVESLADRIYTVKSDVWAFGVTMWEISTRGMTPYPGVQNHEIYDYLLVGHRL 703
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
++PP D LY VM +CW PT RPSFT L+E L +E
Sbjct: 704 KQPPECLDDLYTVMYQCWLSDPTCRPSFTALRENLEKIVE 743
Score = 50.4 bits (115), Expect = 3e-04
Identities = 47/149 (31%), Positives = 71/149 (47%), Gaps = 18/149 (12%)
Query: 572 LLNFKSGNKKSFN--------PNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVV 623
++NFK+ KKS+N LGI++ DL E R L GK LG G FG V
Sbjct: 430 VVNFKA--KKSYNRRAIEITLSTLGINQ--DLQQKLEDVMVERNLLNLGKVLGEGEFGSV 485
Query: 624 YKAEARGIINAEVTTPVAVKMVKR-TADNMYIKALASELKIMVHLGKHVNIVNLLGACTK 682
+ E + + VAVK +K I+ SE M H N++ LLG C +
Sbjct: 486 MEGELQ--YSDGTNHKVAVKTMKMDNFSQREIEEFLSEAACMKDF-NHPNVIRLLGVCLE 542
Query: 683 HIAKR--ELIVIVEYCKYGNIHNYMQKHR 709
+R + +VI+ + KYG++H+++ R
Sbjct: 543 VGPRRIPKPMVILPFMKYGDLHSFLLSSR 571
>UniRef50_Q7PWP1 Cluster: ENSANGP00000013218; n=2; Culicidae|Rep:
ENSANGP00000013218 - Anopheles gambiae str. PEST
Length = 861
Score = 165 bits (400), Expect = 8e-39
Identities = 71/157 (45%), Positives = 103/157 (65%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
P+T +L +A+QI++GM YL + K++H DLAARNVLLA+ V KI DFGL R +Y ++
Sbjct: 598 PITVKDILSFAWQISKGMAYLTDIKLVHRDLAARNVLLAEGKVCKISDFGLTRDVYEDDA 657
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
Y KK +PVKW+A E + D I++T+SDVW++G++ WE+ +L +PYP I P +L L
Sbjct: 658 YLKKSKDRVPVKWMAPESLADHIYTTKSDVWAFGVLCWELITLGASPYPGIPPQNLYNLL 717
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTEL 952
G R+E P + +Y ++ CW P RPSF L
Sbjct: 718 KQGYRMECPKNCSEEIYGIVRLCWADDPKQRPSFKHL 754
Score = 97.9 bits (233), Expect = 1e-18
Identities = 58/161 (36%), Positives = 90/161 (55%), Gaps = 6/161 (3%)
Query: 552 MVAYLFTWKLK-KQRELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLT 610
+V Y F+ KL K + L + N G S + NL + ++ YD K+EFPR L
Sbjct: 430 IVLYCFSRKLTVKNKLLDGSSGANGTIGGMNSISMNL-VSNDTEIFNYDSKWEFPRTNLI 488
Query: 611 FGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKH 670
LG G FG V K A + T VAVKM+K A+++ + AL SE +++ + H
Sbjct: 489 LDATLGEGEFGKVLKGFATDLPEKPGITTVAVKMLKTGANSVELLALLSEYQLLQEV-NH 547
Query: 671 VNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREV 711
N++ LLGACTK + ++I+EYC+YG++ NY++ R++
Sbjct: 548 PNVIRLLGACTKGDSP---LLIIEYCQYGSLKNYLRLSRKL 585
>UniRef50_Q04912 Cluster: Macrophage-stimulating protein receptor
precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CD136
antigen) (CDw136) [Contains: Macrophage- stimulating
protein receptor alpha chain; Macrophage-stimulating
protein receptor beta chain]; n=15; Eutheria|Rep:
Macrophage-stimulating protein receptor precursor (EC
2.7.10.1) (MSP receptor) (p185-Ron) (CD136 antigen)
(CDw136) [Contains: Macrophage- stimulating protein
receptor alpha chain; Macrophage-stimulating protein
receptor beta chain] - Homo sapiens (Human)
Length = 1400
Score = 163 bits (397), Expect = 2e-38
Identities = 84/198 (42%), Positives = 120/198 (60%), Gaps = 11/198 (5%)
Query: 785 GDYIYECHQP-RPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
GD + P R T L+ + Q+ARGMEYLA +K +H DLAARN +L + VK+ D
Sbjct: 1167 GDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVAD 1226
Query: 844 FGLARSMYNNEEY--QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKT 901
FGLAR + + E Y Q+ ++ LPVKW+A+E + F+T+SDVWS+G++LWE+ +
Sbjct: 1227 FGLARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAP 1286
Query: 902 PYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFT----ELQEILG 957
PY +I P DL +L+ G RL +P + D LY VM +CW P RP+F E+++I+
Sbjct: 1287 PYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVS 1346
Query: 958 NFLEDNERNRYVDLNAPY 975
L D+ YV L A Y
Sbjct: 1347 ALLGDH----YVQLPATY 1360
>UniRef50_UPI0000D55DFF Cluster: PREDICTED: similar to Insulin-like
growth factor 1 receptor precursor (Insulin-like growth
factor I receptor) (IGF-I receptor) (CD221 antigen); n=1;
Tribolium castaneum|Rep: PREDICTED: similar to
Insulin-like growth factor 1 receptor precursor
(Insulin-like growth factor I receptor) (IGF-I receptor)
(CD221 antigen) - Tribolium castaneum
Length = 1277
Score = 163 bits (396), Expect = 3e-38
Identities = 74/180 (41%), Positives = 114/180 (63%), Gaps = 1/180 (0%)
Query: 787 YIYECHQP-RPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFG 845
Y+ C P + LT+ + A +IA GM YL+ +K +H DLAARN ++A D VKI DFG
Sbjct: 1007 YLRRCRGPSQNLTTNEIYRMASEIADGMAYLSVKKFVHRDLAARNCMVAADRTVKIGDFG 1066
Query: 846 LARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN 905
+AR +Y + Y+K LP++W+A E + D +F+T SDVWSYG+VLWEM +LA+ PY
Sbjct: 1067 MARDIYETDYYRKGTAGLLPIRWMAPESLADGVFTTDSDVWSYGVVLWEMATLAELPYQG 1126
Query: 906 ISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNER 965
+ ++L++++ G L+ PP D L+ +M CW +P RP+F + + L N + ++ R
Sbjct: 1127 LGAEEVLQFVTSGRTLDMPPQCSDLLHKIMSACWKWRPNDRPTFFSIVDELVNHVGEDFR 1186
Score = 36.7 bits (81), Expect = 3.7
Identities = 26/111 (23%), Positives = 55/111 (49%), Gaps = 8/111 (7%)
Query: 599 DEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALA 658
++ +E R + ++LG G+FG VY+ G+I + P A+K + +
Sbjct: 910 EDDWEIDRNDIEIIRELGKGSFGTVYE----GLIKSR-QYPCAIKTISEKSSISSKMEFL 964
Query: 659 SELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+E +M + +++ LLG ++ R VI+E + G++ +Y+++ R
Sbjct: 965 NEGSVMKSFSETHHVIKLLGIVSR--GDRP-FVIMELMERGDLKSYLRRCR 1012
>UniRef50_O76809 Cluster: Receptor tyrosine kinase HTK30; n=1; Hydra
vulgaris|Rep: Receptor tyrosine kinase HTK30 - Hydra
attenuata (Hydra) (Hydra vulgaris)
Length = 1081
Score = 162 bits (394), Expect = 4e-38
Identities = 73/156 (46%), Positives = 110/156 (70%), Gaps = 1/156 (0%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
LT LL +A+Q+A GMEYLA K +H DLAARN+L+ + +KI DFGL R + + + Y
Sbjct: 927 LTPNDLLCFAWQVASGMEYLACMKFVHRDLAARNILVGANKNIKISDFGLTRKV-DLDVY 985
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
++ LPVKW++IE + DR F++ SDVWS+G+VL+E+ +L TPYP I+ +LL L
Sbjct: 986 MGAKSRRLPVKWMSIEAIFDRTFTSSSDVWSFGVVLFEIITLGGTPYPTITNNELLALLK 1045
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTEL 952
G R+++P +++Y++ML+CW++ P RP+FTEL
Sbjct: 1046 SGYRMDRPGNCSEQMYDIMLQCWNENPLGRPNFTEL 1081
Score = 45.2 bits (102), Expect = 0.011
Identities = 23/70 (32%), Positives = 40/70 (57%), Gaps = 3/70 (4%)
Query: 640 VAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYG 699
VAVK++K +A + E+ +M +G H NIVN++G T K L +IVE+ + G
Sbjct: 817 VAVKILKESATQSELNDFIEEINLMKGIGYHKNIVNMIGCST---IKNSLSLIVEFMQEG 873
Query: 700 NIHNYMQKHR 709
++ +++ R
Sbjct: 874 DLLQFLRNKR 883
>UniRef50_Q25199 Cluster: Tyrosine kinase receptor; n=7; Hydra|Rep:
Tyrosine kinase receptor - Hydra attenuata (Hydra) (Hydra
vulgaris)
Length = 1348
Score = 162 bits (393), Expect = 6e-38
Identities = 71/158 (44%), Positives = 109/158 (68%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
+T LL +A+Q+A GME+L+ K++H DLAARN+L+ VKI DFGL R + + Y
Sbjct: 1131 ITPDDLLSFAWQVASGMEFLSCSKLVHRDLAARNILVGAGKNVKISDFGLTRKINDELNY 1190
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
K+ LPVKW+++E + D++F++ SDVW+YG+VL+E+ +L TPYP IS +LL L
Sbjct: 1191 MSKKKRRLPVKWMSVEAIFDQLFTSFSDVWAYGVVLFEIVTLGGTPYPAISNRELLPLLK 1250
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQE 954
G R++KP + +Y++ML+CW++ P RP+F L+E
Sbjct: 1251 SGYRMDKPENCSEAMYSIMLQCWNEDPLQRPTFATLRE 1288
Score = 69.3 bits (162), Expect = 6e-10
Identities = 54/168 (32%), Positives = 83/168 (49%), Gaps = 25/168 (14%)
Query: 594 DLLPYDEKFEFPREKLTFGKQLGAGAFGVVY-----------------KAEARGIINA-- 634
D + DE FP E +T K++G GAFG V+ K+ +I++
Sbjct: 945 DEITPDEWEIFP-EYITLDKKIGEGAFGTVFIARLSSSVIFKRKKMKLKSHQSSVISSHD 1003
Query: 635 --EVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVI 692
+ T VA K+VK AD+ + A E+K+M +G H NIVNL+G T K+ L +I
Sbjct: 1004 MSDNTFRVAAKLVKDYADSSELSDFAEEIKLMKEIGYHKNIVNLIGCST---LKKPLCLI 1060
Query: 693 VEYCKYGNIHNYMQKHREVFIDQLTDNAEKNLGKINKGFLNSVGTTGT 740
VEY ++G++ N+++K R F D +G+ S+ TT T
Sbjct: 1061 VEYMEHGDLLNFLRKIRSKFCALKIDGKSSVNFLYTQGYQQSLKTTAT 1108
>UniRef50_Q25177 Cluster: Receptor protein-tyrosine kinase; n=2;
Hydra vulgaris|Rep: Receptor protein-tyrosine kinase -
Hydra attenuata (Hydra) (Hydra vulgaris)
Length = 891
Score = 162 bits (393), Expect = 6e-38
Identities = 71/156 (45%), Positives = 106/156 (67%)
Query: 806 AFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLP 865
AFQIA GM +L+ +K++H DLAARNVL+ D ++K+ DFGLAR +Y + Y K+ LP
Sbjct: 657 AFQIASGMLFLSEKKLVHRDLAARNVLVGPDYIMKLADFGLARDIYLSGVYIKESCGILP 716
Query: 866 VKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPP 925
VKW+A E + D++++ +SDVWS+GIVLWE+ ++ +PYP + DL +L+ G R+ +P
Sbjct: 717 VKWMAPESLFDKVYTIKSDVWSFGIVLWEICTMGGSPYPGLPTEDLFEYLTAGKRMCQPV 776
Query: 926 FADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
D LY +ML+CW ++P RP F E+ L +E
Sbjct: 777 TCPDELYEIMLQCWQERPEERPWFHEIVSQLQRIIE 812
Score = 75.4 bits (177), Expect = 9e-12
Identities = 35/75 (46%), Positives = 53/75 (70%), Gaps = 3/75 (4%)
Query: 638 TPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCK 697
T VAVK +K +A ++ + L+SE+K+++HLG+H NIVNLLG+CTK L I+EYC
Sbjct: 562 TFVAVKTLKSSASDVEYRDLSSEIKVLIHLGEHPNIVNLLGSCTK---DGRLCAIMEYCP 618
Query: 698 YGNIHNYMQKHREVF 712
+GN+ +++ R VF
Sbjct: 619 HGNLVGFLRPRRHVF 633
Score = 57.6 bits (133), Expect = 2e-06
Identities = 52/182 (28%), Positives = 74/182 (40%), Gaps = 12/182 (6%)
Query: 459 EGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQE-------KDNGIYE 511
+G P P IYW + N + N +V T+E + KD G
Sbjct: 343 QGNPLPFIYWERKVLSCKNCESQWVNFSSENVKVVPPTYEPSSQSALIFQNSFKDIGSIR 402
Query: 512 CVALNNASELRRAYTLVLKAEKSYT-PYXXXXXXXXXXXXGMVAYLFTWKLKKQRELTKA 570
C A N+ +L A K P + +F +K R K
Sbjct: 403 CHAYNSEGNSSAVISLNYSAGKEPRFPTVGIICGFLVIIFIFLIIIFFYK----RYTNKK 458
Query: 571 GLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARG 630
L + K +P+ I EQ+ LPYD +EFPR +L F + +G+GAFG V+ A ARG
Sbjct: 459 FALFMEPNPKFKLDPSRTIFEQSIELPYDLSWEFPRHRLDFVRVIGSGAFGQVWFAHARG 518
Query: 631 II 632
I+
Sbjct: 519 IL 520
Score = 35.9 bits (79), Expect = 6.4
Identities = 30/100 (30%), Positives = 46/100 (46%), Gaps = 13/100 (13%)
Query: 433 PIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDE-LISNNSGYKLFVDIVNHT 491
PII S K ++ GRSI++ C + P TI WY D L+ S K + D+
Sbjct: 233 PIISLSYSGKPQK---GRSIKIQCLVDSSPSSTIEWYSGDSLLLVCKSSKKPYTDLQ--- 286
Query: 492 IVNSTFEIENMQEKDNGIYECVALN---NASELRRAYTLV 528
+ + I++ N + C+A N N+S+ Y LV
Sbjct: 287 -IPCEYTIQDFNRNTN--FTCIAKNAAGNSSQSLIIYVLV 323
>UniRef50_Q9U5A8 Cluster: Insulin receptor-like protein precursor;
n=1; Bombyx mori|Rep: Insulin receptor-like protein
precursor - Bombyx mori (Silk moth)
Length = 1472
Score = 161 bits (391), Expect = 1e-37
Identities = 71/159 (44%), Positives = 105/159 (66%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P P T ++L A +IA GM YL+ +K +H DLAARN ++A D VK+ DFG+ R +Y
Sbjct: 1190 PVPPTLQNILQMAIEIADGMAYLSAKKFVHRDLAARNCMVAGDLTVKVGDFGMTRDIYET 1249
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
+ Y+K +PV+W++ E + D +FS+ SD WSYG+VLWEM +LA PY +S +LR
Sbjct: 1250 DYYRKGTKGLMPVRWMSPESLKDGVFSSSSDAWSYGVVLWEMATLAMQPYQGLSNEQVLR 1309
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTEL 952
++ +G +E+P DRLY +M CW +P+ARP+F +L
Sbjct: 1310 YVVEGGVMERPEQCPDRLYELMRACWTHRPSARPTFLQL 1348
Score = 48.0 bits (109), Expect = 0.001
Identities = 28/110 (25%), Positives = 58/110 (52%), Gaps = 4/110 (3%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+++E R+ + F ++LG G+FG+VY+ A+ I+ + T A+K V A + +
Sbjct: 1073 DEWEVTRDSIHFIRELGQGSFGMVYEGIAKEIVKGKPETRCAIKTVNEHATDRERIEFLN 1132
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
E +M ++V LLG ++ + +V++E + G++ Y++ R
Sbjct: 1133 EASVMKAFDT-FHVVRLLGVVSR---GQPTLVVMELMERGDLKTYLRSMR 1178
>UniRef50_Q8MY85 Cluster: Fibroblast growth factor receptor 2
precursor; n=3; Dugesia japonica|Rep: Fibroblast growth
factor receptor 2 precursor - Dugesia japonica
(Planarian)
Length = 887
Score = 161 bits (391), Expect = 1e-37
Identities = 74/156 (47%), Positives = 107/156 (68%), Gaps = 2/156 (1%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
LT L ++ +IA GMEYL++RK++H DLAARNVL+ +KI DFGL R + N Y
Sbjct: 700 LTVTDFLRFSIEIAEGMEYLSSRKIIHRDLAARNVLVDQYVEMKIADFGLTRIVENY--Y 757
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
+K + LP+KW+A EC++DR+++ +SDVWSYGIVLWE+F++ +TPYP I + + L
Sbjct: 758 RKTTDGRLPIKWMAPECLLDRVYTVKSDVWSYGIVLWEIFTMGQTPYPTIQSDGMHQALR 817
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTEL 952
+G R EKP A D +Y +ML W+ P R +F+E+
Sbjct: 818 NGIRNEKPALASDEMYRLMLTIWNDDPLERHTFSEI 853
Score = 69.7 bits (163), Expect = 4e-10
Identities = 40/145 (27%), Positives = 75/145 (51%), Gaps = 6/145 (4%)
Query: 568 TKAGLLNFKSGNKKSFNPNLGIDEQAD---LLPYDEKFEFPREKLTFGKQLGAGAFGVVY 624
T+ L S ++ P L + A+ +LP + + F R+ L G ++G GAFG+VY
Sbjct: 541 TETNKLTSNSLTVETQRPQLILQNDANTKYILPSNIGWIFSRDSLIIGSKIGEGAFGIVY 600
Query: 625 KAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHI 684
A + + VA+K + + + + L EL++M +G+H +I++L GAC I
Sbjct: 601 SALVKSFSENSASVEVAIKTLHTSFGDQDVINLIQELEMMKIIGRHRHIISLYGAC---I 657
Query: 685 AKRELIVIVEYCKYGNIHNYMQKHR 709
+++E K+GN+ ++++ R
Sbjct: 658 DNGHPYMVIELAKHGNLRDFLRAQR 682
>UniRef50_Q70W11 Cluster: Receptor tyrosine kinase X; n=1; Ciona
intestinalis|Rep: Receptor tyrosine kinase X - Ciona
intestinalis (Transparent sea squirt)
Length = 478
Score = 160 bits (389), Expect = 2e-37
Identities = 68/152 (44%), Positives = 103/152 (67%), Gaps = 1/152 (0%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+G+ Q +GM YLA+++ +H DLAARN +L + VVK+ DFGLAR +Y E Y+ E+
Sbjct: 254 LVGFGLQACKGMCYLASQRFVHRDLAARNCMLNETYVVKVADFGLARDIYEKEYYKPHEH 313
Query: 862 SP-LPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNR 920
+ +PVKW+A+E + + F+ ++DVWS+GI+LWE+ + TPYP++ D++ ++ DG R
Sbjct: 314 AGRMPVKWMALESLQQQTFTIKTDVWSFGILLWELLTRGVTPYPDVDAFDVVNYILDGRR 373
Query: 921 LEKPPFADDRLYNVMLRCWHQKPTARPSFTEL 952
L +P + D LY +ML CWH P RP F L
Sbjct: 374 LRQPQYCPDPLYELMLSCWHPLPETRPDFVTL 405
>UniRef50_Q7Q0F6 Cluster: Tyrosine-protein kinase receptor; n=2;
Cellia|Rep: Tyrosine-protein kinase receptor - Anopheles
gambiae str. PEST
Length = 1318
Score = 160 bits (388), Expect = 2e-37
Identities = 75/170 (44%), Positives = 109/170 (64%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P+P T + A +IA GM YLA +K +H DLAARN ++A+D VKI DFG+ R +Y
Sbjct: 1099 PQPPTLKQIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVAEDLTVKIGDFGMTRDIYET 1158
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
+ Y+K LPV+W+A E + D +FS+ SDV+SYG+VLWEM +LA PY ++ +LR
Sbjct: 1159 DYYRKGTKGFLPVRWMAPESLKDGMFSSSSDVFSYGVVLWEMATLASQPYQGLTNDQVLR 1218
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
++ DG +E+P D+LY +M CW + +ARPSF ++ +L DN
Sbjct: 1219 YVIDGGVMERPENCPDKLYELMRICWQHRASARPSFIDIIRMLLPDANDN 1268
Score = 52.4 bits (120), Expect = 7e-05
Identities = 33/110 (30%), Positives = 57/110 (51%), Gaps = 5/110 (4%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+++E PRE + ++LG G+FG+VYK + N +V P A+K V A +
Sbjct: 984 DEWEVPREHIIQLEELGQGSFGMVYKGIMTKLGN-DVNVPCAIKTVTENATERERDSFLI 1042
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
E IM H ++V L G + + +VI+E G++ +Y+++HR
Sbjct: 1043 EATIMKEFHTH-HVVRLYGVVS---VGQPTLVIMELMANGDLKSYLRRHR 1088
>UniRef50_Q06418 Cluster: Tyrosine-protein kinase receptor TYRO3
precursor; n=30; Tetrapoda|Rep: Tyrosine-protein kinase
receptor TYRO3 precursor - Homo sapiens (Human)
Length = 890
Score = 160 bits (388), Expect = 2e-37
Identities = 71/160 (44%), Positives = 108/160 (67%), Gaps = 4/160 (2%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ + IA GMEYL++R +H DLAARN +LA+D V + DFGL+R +Y+ + Y++
Sbjct: 632 LIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCA 691
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
S LPVKWLA+E + D +++ QSDVW++G+ +WE+ + +TPY I ++ +L GNRL
Sbjct: 692 SKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRL 751
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFT----ELQEILG 957
++PP + +Y++M +CW P RPSFT EL+ ILG
Sbjct: 752 KQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILG 791
Score = 41.9 bits (94), Expect = 0.098
Identities = 37/128 (28%), Positives = 62/128 (48%), Gaps = 9/128 (7%)
Query: 586 NLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMV 645
+LGI ++ L E P ++ T G+ LG G FG V +A+ + + V VAVKM+
Sbjct: 497 SLGISDE--LKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFV--KVAVKML 552
Query: 646 KR-TADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKREL---IVIVEYCKYGNI 701
K + I+ E M H ++ L+G + AK L +VI+ + K+G++
Sbjct: 553 KADIIASSDIEEFLREAACMKEF-DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDL 611
Query: 702 HNYMQKHR 709
H ++ R
Sbjct: 612 HAFLLASR 619
Score = 37.1 bits (82), Expect = 2.8
Identities = 16/65 (24%), Positives = 34/65 (52%), Gaps = 3/65 (4%)
Query: 448 EGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDN 507
+G+ ++L+C EG+ P I W KD ++ N +L++ + + +++++ D
Sbjct: 56 QGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLD--QLYIPVSEQHWI-GFLSLKSVERSDA 112
Query: 508 GIYEC 512
G Y C
Sbjct: 113 GRYWC 117
>UniRef50_Q5BXN9 Cluster: SJCHGC05493 protein; n=1; Schistosoma
japonicum|Rep: SJCHGC05493 protein - Schistosoma
japonicum (Blood fluke)
Length = 418
Score = 159 bits (387), Expect = 3e-37
Identities = 74/151 (49%), Positives = 96/151 (63%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L W+ QIA GM YL++R ++H DLAARNVL+ + VKI DFGLA+ + +
Sbjct: 267 LFQWSEQIASGMAYLSSRGIIHRDLAARNVLVQSKDQVKITDFGLAKCLDTSHNEYHASG 326
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
+P+KWLAIE + +RIFS +SDVW+YGI LWEM + PY NI DLL +L GNRL
Sbjct: 327 GRMPIKWLAIESIQERIFSYKSDVWAYGITLWEMCTFGHRPYENIHAKDLLDYLEKGNRL 386
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTEL 952
+P Y +ML+CWH P RP+F EL
Sbjct: 387 PQPETTSLEFYCLMLQCWHTDPNLRPTFKEL 417
>UniRef50_Q9Y1Y7 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 709
Score = 159 bits (386), Expect = 4e-37
Identities = 79/183 (43%), Positives = 115/183 (62%), Gaps = 9/183 (4%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKE- 860
LL QIA+GMEYLA++K +H DLAARN ++ +NV+K+ DFGL+ MY Y++ +
Sbjct: 503 LLSICLQIAKGMEYLASQKFVHRDLAARNCMIDLNNVIKVADFGLSEDMYAKNYYRQSDV 562
Query: 861 ---NSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSD 917
LP++W+A E D +FS ++DVWSYG+ WE+F+L K PYP ++P L+++L +
Sbjct: 563 EECKVKLPIRWMAPESFHDGVFSEKTDVWSYGVTCWEVFTLGKIPYPGVTPFTLIKYLDE 622
Query: 918 GNRLEKPPFA--DDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLN-AP 974
G RLEKP A D++Y++M +CW Q+ RP F+ L + LE YVD P
Sbjct: 623 GGRLEKPSNAACSDQIYDLMRKCWCQESEDRPPFSNLVLAICGILE--PLAGYVDFRLLP 680
Query: 975 YNE 977
NE
Sbjct: 681 ANE 683
Score = 42.3 bits (95), Expect = 0.074
Identities = 32/125 (25%), Positives = 60/125 (48%), Gaps = 7/125 (5%)
Query: 601 KFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVK-RTADNMYIKALAS 659
K P + L +G G FG+VY+A R VAVK +K T+D+ + L
Sbjct: 377 KMLIPEQCLQIMDCIGQGEFGIVYRAYLREWAKYPSPHLVAVKTIKGETSDSQISQMLEE 436
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDN 719
+K+ H NI++L+G C + +++ + G++ +Y+++ R + +
Sbjct: 437 SVKMKDF--DHPNILSLIGVCI--AIESSPYIVMPFMANGSLLSYLKQQRHNL--TIANG 490
Query: 720 AEKNL 724
AE++L
Sbjct: 491 AEQDL 495
>UniRef50_P09208 Cluster: Insulin-like receptor precursor (EC
2.7.10.1) (DIR) (DInr) (dIRH) [Contains: Insulin-like
receptor subunit alpha; Insulin-like receptor subunit
beta 1; Insulin-like receptor subunit beta 2]; n=15;
Eumetazoa|Rep: Insulin-like receptor precursor (EC
2.7.10.1) (DIR) (DInr) (dIRH) [Contains: Insulin-like
receptor subunit alpha; Insulin-like receptor subunit
beta 1; Insulin-like receptor subunit beta 2] -
Drosophila melanogaster (Fruit fly)
Length = 2144
Score = 159 bits (386), Expect = 4e-37
Identities = 72/158 (45%), Positives = 105/158 (66%)
Query: 795 RPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNE 854
+P T G + A +IA GM YLA +K +H DLAARN ++ADD VKI DFG+ R +Y +
Sbjct: 1489 QPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETD 1548
Query: 855 EYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRW 914
Y+K LPV+W+ E + D ++S+ SDV+S+G+VLWEM +LA PY +S +LR+
Sbjct: 1549 YYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRY 1608
Query: 915 LSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTEL 952
+ DG +E+P D L+ +M RCWH + +ARPSF ++
Sbjct: 1609 VIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDI 1646
Score = 48.4 bits (110), Expect = 0.001
Identities = 30/110 (27%), Positives = 54/110 (49%), Gaps = 4/110 (3%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+ +E RE + LG G+FG+VY+ + V A+K V A + S
Sbjct: 1362 DDWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLS 1421
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
E +M + ++V LLG C++ + +V++E K G++ +Y++ HR
Sbjct: 1422 EASVMKEFDTY-HVVRLLGVCSR---GQPALVVMELMKKGDLKSYLRAHR 1467
>UniRef50_A7RGV3 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 250
Score = 159 bits (385), Expect = 5e-37
Identities = 79/183 (43%), Positives = 116/183 (63%), Gaps = 3/183 (1%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
L LL A +ARGM +L ++ +H DLAARNVL+ V K+ DFGLAR + + Y
Sbjct: 68 LNERQLLFLALGVARGMAHLEEKQCIHRDLAARNVLVGLGLVAKVADFGLARHVTTDGLY 127
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN-ISPTDLLRWL 915
+ LP KW+A E + +++T+SDVWS+G+VLWE+ +L +TPYPN +S LL+ L
Sbjct: 128 IVSAQTKLPWKWMAPESLRG-LYTTKSDVWSFGVVLWEIATLGETPYPNEVSIMKLLQHL 186
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLNAPY 975
DG+R+ KPP+ D+ +Y +ML CW P RPSF E++ L LE+ R YV+++
Sbjct: 187 IDGHRMSKPPYCDEEIYKLMLECWQLDPATRPSFKEIERTLKKLLEEAYRT-YVNVSPVE 245
Query: 976 NEM 978
+E+
Sbjct: 246 DEI 248
Score = 43.2 bits (97), Expect = 0.042
Identities = 18/53 (33%), Positives = 35/53 (66%), Gaps = 3/53 (5%)
Query: 657 LASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ +E+ I+ H+G+H N+V+L+GACT L V++E+ + G++ + + K R
Sbjct: 1 MMTEMDILKHVGRHPNVVSLVGACT---LDEPLFVVIEFVEGGDLRDLLLKSR 50
>UniRef50_Q9YI66 Cluster: Developmental receptor tyrosine kinase;
n=6; Bilateria|Rep: Developmental receptor tyrosine
kinase - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 874
Score = 158 bits (384), Expect = 7e-37
Identities = 64/160 (40%), Positives = 106/160 (66%)
Query: 793 QPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYN 852
+P ++ L+ + IARGMEYL+N+ ++H DLAARN +L ++ V + DFGL++ +Y+
Sbjct: 602 EPFTVSQQILIQFMLDIARGMEYLSNKNIIHRDLAARNCMLNENMSVCVADFGLSKKIYS 661
Query: 853 NEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLL 912
+ Y++ S LPVKW+A+E + D +++TQSDVW++G+ +WE+ + +TPYP + +++
Sbjct: 662 GDYYRQGSVSKLPVKWIALESLADNVYTTQSDVWAFGVTMWEIMTRGQTPYPGVENSEIY 721
Query: 913 RWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTEL 952
+L G RL++PP +Y +M CW P RPSF L
Sbjct: 722 EYLIKGERLKQPPDCPADIYEIMHSCWSPVPKCRPSFQHL 761
Score = 41.5 bits (93), Expect = 0.13
Identities = 31/105 (29%), Positives = 53/105 (50%), Gaps = 7/105 (6%)
Query: 609 LTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMY-IKALASELKIMVHL 667
LT G+ LG G FG V +A + N+ VAVK++K ++ I+ E M
Sbjct: 497 LTLGRMLGKGEFGSVREAFLKSENNS--GQKVAVKVLKTDINSSSDIEQCLKEAAYMKDF 554
Query: 668 GKHVNIVNLLGACTKHIAKREL---IVIVEYCKYGNIHNYMQKHR 709
H N++ L+G A++ L +VI+ + K+G++H ++ R
Sbjct: 555 -HHPNVIQLIGVSLHRRAQQRLPIPMVILPFMKHGDLHTFLLMSR 598
Score = 36.7 bits (81), Expect = 3.7
Identities = 18/65 (27%), Positives = 34/65 (52%), Gaps = 3/65 (4%)
Query: 448 EGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDN 507
+G ++L C EG+ P I W KD E + + + +D + +S ++++Q++D
Sbjct: 34 QGNMVRLGCAFEGLSEPEIIWMKDGEKLFSTDQMYITLDPYHWETFHS---VKSVQQQDA 90
Query: 508 GIYEC 512
G Y C
Sbjct: 91 GKYWC 95
>UniRef50_Q5K4G5 Cluster: Receptor tyrosine kinase; n=1; Suberites
domuncula|Rep: Receptor tyrosine kinase - Suberites
domuncula (Sponge)
Length = 715
Score = 158 bits (383), Expect = 9e-37
Identities = 73/163 (44%), Positives = 108/163 (66%), Gaps = 2/163 (1%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
PL+ + + A Q+A GM YLA+++ +H DLAARNVL+ D +K+ DFGLAR MY++
Sbjct: 489 PLSVQNQVAIASQVANGMAYLASKRCIHRDLAARNVLITKDLTLKVADFGLARKMYSS-- 546
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
+ LP+KW+A E ++D + +++SDVWS+GI+LWE+ +L +TPYP S ++R +
Sbjct: 547 VYRPSGKRLPIKWMAPEGILDGVCTSKSDVWSFGILLWEIMTLGRTPYPGRSAHWVIRDI 606
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGN 958
+G R+ +P D+LY+VM CW P ARP FTEL L N
Sbjct: 607 ENGYRMPQPDGCPDKLYSVMKCCWQMNPIARPEFTELTNSLDN 649
Score = 78.2 bits (184), Expect = 1e-12
Identities = 44/105 (41%), Positives = 65/105 (61%), Gaps = 4/105 (3%)
Query: 605 PREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIM 664
P L LG+GAFGVV KAE I+ + T+ VAVKM+K +A K + ELK++
Sbjct: 383 PFHLLNLKDDLGSGAFGVVKKAELFDPIS-QTTSIVAVKMLKESASTEDEKDIIMELKVL 441
Query: 665 VHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
H+G+H N+V+ LGA + K +L +IVEYC+ GN+ +++ R
Sbjct: 442 YHVGEHCNVVSFLGA---SVHKGKLHLIVEYCERGNLLQFLRSKR 483
>UniRef50_UPI00015B5959 Cluster: PREDICTED: similar to insulin
receptor; n=1; Nasonia vitripennis|Rep: PREDICTED:
similar to insulin receptor - Nasonia vitripennis
Length = 1714
Score = 157 bits (382), Expect = 1e-36
Identities = 72/162 (44%), Positives = 105/162 (64%)
Query: 795 RPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNE 854
+P T ++ A +IA GM YLA +K +H DLAARN +++DD VKI DFG+ R +Y +
Sbjct: 1235 QPPTLNRIMRMALEIADGMAYLAAKKFVHRDLAARNCMVSDDLTVKIGDFGMTRDVYETD 1294
Query: 855 EYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRW 914
Y+K LPV+W+A E + D +F++ SDVWSYG+VLWEM +LA PY +S +LR+
Sbjct: 1295 YYRKGTKGLLPVRWMAPESLKDGVFTSFSDVWSYGVVLWEMVTLASQPYQGLSNDQVLRY 1354
Query: 915 LSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEIL 956
+ DG +E+P D LY +M + W K T RP+F +++ L
Sbjct: 1355 VIDGGVMERPENCPDILYGMMRQTWCHKATRRPTFIDIEREL 1396
Score = 56.4 bits (130), Expect = 4e-06
Identities = 31/110 (28%), Positives = 59/110 (53%), Gaps = 4/110 (3%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+++E PR+K+ K+LG G+FG+VY+ A+ ++ + AVK V A + +
Sbjct: 1120 DEWEVPRKKVHLLKELGNGSFGMVYEGIAKDVVKGKPEMRCAVKTVNENATDRERVEFLN 1179
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
E +M H ++V LLG ++ + +V++E G++ Y++ HR
Sbjct: 1180 EASVMKGFNTH-HVVRLLGVVSQ---GQPTLVVMELMVNGDLKTYLRSHR 1225
>UniRef50_UPI0000E49FB6 Cluster: PREDICTED: similar to RE05926p,
partial; n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to RE05926p, partial -
Strongylocentrotus purpuratus
Length = 859
Score = 157 bits (382), Expect = 1e-36
Identities = 73/192 (38%), Positives = 117/192 (60%), Gaps = 2/192 (1%)
Query: 772 EGYIQQ-EWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARN 830
+GY++Q DY + + + LL + QIARGMEYLA+R+ +H DLAARN
Sbjct: 403 QGYLRQIRTGESMTADY-RNVKKQKDIPPNDLLTFGVQIARGMEYLASRQCIHRDLAARN 461
Query: 831 VLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGI 890
+LL + V K+ DFGLAR + + + Y+ K +PV+W++ E ++ +++QSDVWS+ I
Sbjct: 462 ILLGEGYVCKVSDFGLARDLEDGQTYEMKSQGRVPVRWMSPESLLHNTYTSQSDVWSFAI 521
Query: 891 VLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFT 950
++WE+ +L PYP +S +++ +S G RL KP +YN+M CW + RP+F+
Sbjct: 522 LIWEIVTLGSHPYPGMSSKQVVKEISAGYRLPKPEHCSQDIYNLMKECWAYEAEERPTFS 581
Query: 951 ELQEILGNFLED 962
+++ L N L D
Sbjct: 582 QVKVRLENMLAD 593
Score = 89.4 bits (212), Expect = 5e-16
Identities = 53/125 (42%), Positives = 69/125 (55%), Gaps = 7/125 (5%)
Query: 585 PNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKM 644
PNL I D K EFPR +LT +LG+G+F VYKAEA GII E T VAVK
Sbjct: 293 PNLRISTMRDAT----KMEFPRNRLTLFNKLGSGSFADVYKAEAVGIITKEEKTIVAVKR 348
Query: 645 VKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNY 704
+K TA L+ EL + ++L H NIVN+LG CT +I+EY N+ Y
Sbjct: 349 LKETATENDKSDLSKELSLYMYLDPHPNIVNILGCCTD---SDPWYIIMEYLPNNNLQGY 405
Query: 705 MQKHR 709
+++ R
Sbjct: 406 LRQIR 410
Score = 83.4 bits (197), Expect = 3e-14
Identities = 46/97 (47%), Positives = 58/97 (59%), Gaps = 4/97 (4%)
Query: 585 PNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKM 644
PNL + D + K EFPR +LT +LG+G+F VYKAEA GII E T VAVK
Sbjct: 118 PNLRVSTMRD----ETKMEFPRNRLTLLNKLGSGSFADVYKAEALGIITKEQKTIVAVKR 173
Query: 645 VKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACT 681
+K TA L+ EL + ++L H NIVN+LG CT
Sbjct: 174 LKDTATENDKSDLSKELSLYMYLDPHPNIVNILGCCT 210
>UniRef50_Q4RJ67 Cluster: Chromosome 1 SCAF15039, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 1
SCAF15039, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 978
Score = 157 bits (382), Expect = 1e-36
Identities = 77/175 (44%), Positives = 111/175 (63%), Gaps = 5/175 (2%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
LTS LL +A +A GM YL++++ +H DLAARNVL+ D+ V KI DFGL+R E Y
Sbjct: 791 LTSQQLLQFAVDVATGMHYLSDKQFIHRDLAARNVLVGDNLVAKIADFGLSRG---EEVY 847
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
KK LPV+W+AIE + +++T+SDVWS+G++LWE+ SL TPY ++ +L L
Sbjct: 848 VKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLP 907
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDL 971
G R+EKP DD +Y +M +CW +P RP F+++ L E R YV++
Sbjct: 908 QGFRMEKPKNCDDEVYELMKQCWRDRPYERPPFSQISVQLSRMQE--ARKAYVNM 960
Score = 64.1 bits (149), Expect = 2e-08
Identities = 37/108 (34%), Positives = 58/108 (53%), Gaps = 6/108 (5%)
Query: 607 EKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVH 666
E + F +G G FG V KA + N A+KM+K A + A EL+++
Sbjct: 677 EDIKFEDVIGEGNFGQVIKAMVKKDGNK---MSAAIKMLKEFASENDHRDFAGELEVLCK 733
Query: 667 LGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFID 714
LG+H NI+NL+GAC + L + +EY YGN+ ++++K R + D
Sbjct: 734 LGQHPNIINLIGACEN---RGYLYIAIEYAPYGNLLDFLRKSRVLETD 778
>UniRef50_A7RNB1 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 280
Score = 157 bits (382), Expect = 1e-36
Identities = 66/160 (41%), Positives = 104/160 (65%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
L+ LL A ARGM +++ + +H DLA RNVL+ +D KI DFGL+R +Y++ Y
Sbjct: 118 LSGKDLLKLALGAARGMRHISGNRFVHRDLATRNVLVTEDLTAKITDFGLSRDIYSDGIY 177
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
+ LP+KW+A E ++D +++TQSD+WS+G+++WE++S PY + P +LL L
Sbjct: 178 LNAKGGKLPLKWMAPESLLDYVYTTQSDIWSFGVLMWEVWSFGAMPYSAVVPNELLSMLM 237
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEIL 956
G RL +PP + +Y+VM+ CW+ +P RPSF +L +L
Sbjct: 238 SGFRLSRPPLCPEEIYDVMMSCWNAEPEVRPSFAKLCTVL 277
Score = 65.7 bits (153), Expect = 7e-09
Identities = 36/108 (33%), Positives = 60/108 (55%), Gaps = 5/108 (4%)
Query: 602 FEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASEL 661
+E PR+++ +LG G FG+V + E +I E VA+KM+K AD K + EL
Sbjct: 1 WEIPRDRVVLKDKLGEGEFGIVMEGEL--LIEEEAPRKVAIKMLKSDADRTDHKDMLREL 58
Query: 662 KIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ +G+H N+V+L+GACT + L +I E+ G + +++ R
Sbjct: 59 DMFKGIGQHENVVSLIGACTLGM---PLYIITEFIAGGTLLELLRESR 103
>UniRef50_Q12866 Cluster: Proto-oncogene tyrosine-protein kinase MER
precursor; n=30; root|Rep: Proto-oncogene
tyrosine-protein kinase MER precursor - Homo sapiens
(Human)
Length = 999
Score = 157 bits (382), Expect = 1e-36
Identities = 69/168 (41%), Positives = 108/168 (64%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P+ + LL + IA GMEYL+NR LH DLAARN +L DD V + DFGL++ +Y+
Sbjct: 692 PKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSG 751
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
+ Y++ + +PVKW+AIE + DR+++++SDVW++G+ +WE+ + TPYP + ++
Sbjct: 752 DYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIRTRGMTPYPGVQNHEMYD 811
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
+L G+RL++P D LY +M CW P RP+F+ L+ L LE
Sbjct: 812 YLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLE 859
Score = 46.0 bits (104), Expect = 0.006
Identities = 37/123 (30%), Positives = 59/123 (47%), Gaps = 8/123 (6%)
Query: 586 NLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMV 645
+LG+ E+ L E R L GK LG G FG V + + + VAVK +
Sbjct: 566 SLGVSEE--LQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQ--EDGTSLKVAVKTM 621
Query: 646 KR-TADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKR--ELIVIVEYCKYGNIH 702
K + + I+ SE M H N++ LLG C + ++ + +VI+ + KYG++H
Sbjct: 622 KLDNSSHREIEEFLSEAACMKDFS-HPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLH 680
Query: 703 NYM 705
Y+
Sbjct: 681 TYL 683
>UniRef50_O97191 Cluster: Tyrosine-protein kinase receptor; n=1;
Geodia cydonium|Rep: Tyrosine-protein kinase receptor -
Geodia cydonium (Sponge)
Length = 570
Score = 157 bits (381), Expect = 2e-36
Identities = 70/188 (37%), Positives = 113/188 (60%), Gaps = 1/188 (0%)
Query: 792 HQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMY 851
H P+ L L ++ARGMEYL+N +H DLAARN +++ + V++ DFGL+R +Y
Sbjct: 377 HFPQGLDEERALVMCLEVARGMEYLSNSSFVHRDLAARNCMVSGELTVRVADFGLSRDVY 436
Query: 852 NNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDL 911
+ + Y+ + LPVKW+A E + D IF+ +SDVWS+G+V WE+FSL PYP I ++
Sbjct: 437 SKDYYRMGTKTMLPVKWMAPESLADNIFTVKSDVWSFGVVCWEVFSLV-APYPGIGNHEM 495
Query: 912 LRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDL 971
++ G RL+ P +Y +M +CW+++ RP+F+EL L ++ Y+++
Sbjct: 496 SDYIGGGRRLKIPRLCPREIYELMEQCWNEESNKRPNFSELVSQLERVIDTRLNPHYMNM 555
Query: 972 NAPYNEMN 979
N + N
Sbjct: 556 NNGTTQQN 563
Score = 49.2 bits (112), Expect = 6e-04
Identities = 30/104 (28%), Positives = 51/104 (49%), Gaps = 2/104 (1%)
Query: 607 EKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVH 666
++L + LG GAFG VYK + + + T VA+K +K + I E +M+
Sbjct: 267 DQLILTESLGEGAFGRVYKGSMKTGDDDDRTVEVAIKTLKDISQQENIDNFVQESILMLG 326
Query: 667 LGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHRE 710
H N++ LLG C + LIV+ + G++ +Y+ R+
Sbjct: 327 F-NHPNVLELLGVCFDTTDRHPLIVL-PFMANGDLRSYLMSKRD 368
>UniRef50_A7S934 Cluster: Predicted protein; n=4; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 304
Score = 157 bits (380), Expect = 2e-36
Identities = 71/163 (43%), Positives = 101/163 (61%)
Query: 788 IYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLA 847
+ E Q P+T +A++IA+GM +L +K +H DLAARN+LL DNV + DFGL+
Sbjct: 126 VTEKTQGAPMTEKEKFKFAYEIAKGMRHLEKKKCVHRDLAARNILLNVDNVAMVSDFGLS 185
Query: 848 RSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS 907
R +Y + Y LPV+W+AIE + D ++T+SDVWSYG++LWEM S PY +S
Sbjct: 186 RDVYESGAYDNTTGGVLPVRWMAIESLEDYTYTTKSDVWSYGVLLWEMESGGLMPYAGMS 245
Query: 908 PTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFT 950
++L L G RLEKP LY +M CW+ +P RP+F+
Sbjct: 246 GVEILERLKQGYRLEKPSCCSQELYALMYECWNPEPKNRPAFS 288
Score = 77.4 bits (182), Expect = 2e-12
Identities = 49/123 (39%), Positives = 72/123 (58%), Gaps = 11/123 (8%)
Query: 603 EFPREKLTFGKQLGAGAFGVVYKA------EARGIINAEVTTPVAVKMVKRTADNMYIKA 656
E PR+ LT +QLG+GAFGVV KA E +G + E+ P AVKM+K ++
Sbjct: 1 EIPRDDLTIERQLGSGAFGVVKKAKTEEPEEEKGKV-LEIV-PCAVKMLKENPTESELRD 58
Query: 657 LASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQL 716
L +E+ IM +G H NIV+LLGACT L ++V+ + G +Y+++HR V +
Sbjct: 59 LCNEIAIMALVGDHPNIVSLLGACT---VNGPLWLVVKLAENGCFLDYIKEHRSVVEYEN 115
Query: 717 TDN 719
T+N
Sbjct: 116 TEN 118
>UniRef50_Q25197 Cluster: Putative insulin-like peptide receptor
precursor; n=8; Eumetazoa|Rep: Putative insulin-like
peptide receptor precursor - Hydra attenuata (Hydra)
(Hydra vulgaris)
Length = 1477
Score = 157 bits (380), Expect = 2e-36
Identities = 96/278 (34%), Positives = 143/278 (51%), Gaps = 13/278 (4%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
PL + +IA GM YLA RK +H DLAARN ++A D VKI DFG+AR +Y
Sbjct: 1146 PLMRQEIYQMVAEIADGMAYLAARKFVHCDLAARNCMVASDFTVKIGDFGMARDIYERNY 1205
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
Y+K S LP++W+A E + D IFST SDVWS+G+VLWE+ +LA PY + +L ++
Sbjct: 1206 YRKDGKSLLPIRWMAPESLKDGIFSTASDVWSFGVVLWEICTLASQPYQGKTNEQVLNFV 1265
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLNAPY 975
L+ P D +L M CWH+ P RPSF E+ +L N ++D+ +V ++ Y
Sbjct: 1266 LSNGHLDYPEGCDYQLREFMSLCWHRDPKMRPSFLEIVHVLENEVDDD----FVMVSF-Y 1320
Query: 976 NEMNAE-----LMTGEDYL---AMVCAPDYNNIVTPSPNYVNMAKSFFPATPTPKDQEGY 1027
+EM + M E Y+ A + Y N ++ +++ A K++
Sbjct: 1321 HEMKRKALEDIYMKSESYIKSDAYTMSDGYTKGDGNMQNMLSRSQNRKSAIEKSKERLSI 1380
Query: 1028 LPMSPTSDQTKYMAHGTKFDFDSRKLNPRVSEASNVGS 1065
+ + KY A+ T + +K PR S V S
Sbjct: 1381 SSLDSGTYVEKYDANDTPEEIPKKKKRPRSKRNSAVDS 1418
Score = 40.7 bits (91), Expect = 0.23
Identities = 29/110 (26%), Positives = 55/110 (50%), Gaps = 5/110 (4%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+++E REK+ ++LG G+FG+V++ A G I VAVK A +
Sbjct: 1035 DEWELNREKIELIRELGQGSFGMVFEGIAHG-IGDHAELRVAVKTTNENASIHDRIQILQ 1093
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
E IM + ++V L+G ++ + V++E G++ +Y+++ R
Sbjct: 1094 EASIMKAFNCN-HVVKLIGVVSQ---GQPTFVVMELMGRGDLKSYLKERR 1139
>UniRef50_UPI00015B5971 Cluster: PREDICTED: similar to leukocyte
receptor tyrosine protein kinase; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to leukocyte receptor
tyrosine protein kinase - Nasonia vitripennis
Length = 1472
Score = 156 bits (379), Expect = 3e-36
Identities = 68/173 (39%), Positives = 109/173 (63%), Gaps = 3/173 (1%)
Query: 793 QPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLA---DDNVVKICDFGLARS 849
+P LT L+ A+ +A+G +Y+ + +H D+AARN LL+ VVKI DFG+AR
Sbjct: 1019 RPTTLTMQSLIMCAYDVAKGCKYMEEARFIHRDIAARNCLLSCKGPGRVVKIADFGMARD 1078
Query: 850 MYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPT 909
+Y ++ Y+K + LP+KW+ E +D IF+T++DVW++G++LWE+ S PY +
Sbjct: 1079 IYRSDYYRKGGKAMLPIKWMPPESFLDGIFTTKTDVWAFGVLLWEIMSFGYMPYTGCANR 1138
Query: 910 DLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLED 962
+++ ++ G RLE+P D +Y +M RCWH P RPSF+ + E +G L+D
Sbjct: 1139 EVMSMVTSGGRLERPAGCPDPIYGIMTRCWHPHPEERPSFSSIVERIGYCLQD 1191
Score = 45.6 bits (103), Expect = 0.008
Identities = 35/127 (27%), Positives = 60/127 (47%), Gaps = 8/127 (6%)
Query: 583 FNPNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAV 642
FNPN + +L + + + PR+ +T K LG GAFG V++ + + E PVAV
Sbjct: 896 FNPNY--EFAGNLYSFKDLPQIPRDSVTLVKPLGQGAFGEVFQGVYKYSRSEE--HPVAV 951
Query: 643 KMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIH 702
K + + + E IM +H NIV +G K +++E G++
Sbjct: 952 KTLPSVSTSQAEADFMMEALIMSKF-EHPNIVQFIGI---SFDKHPRYIVLELLAGGDLK 1007
Query: 703 NYMQKHR 709
N++++ R
Sbjct: 1008 NFLREER 1014
>UniRef50_A7SAX2 Cluster: Predicted protein; n=3; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 315
Score = 156 bits (379), Expect = 3e-36
Identities = 76/171 (44%), Positives = 107/171 (62%), Gaps = 1/171 (0%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P L S L+ +A+ IA GM +LA K +H DLAARNVL+ + N KI D GLAR + +
Sbjct: 144 PSRLVSKDLVKFAWMIADGMAFLAANKCVHRDLAARNVLVGEHNTCKISDLGLARDV-SQ 202
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
+ Y + ++ LPVKW+ E ++ S+ SDVWSYGIVLWE+F++ +PYP + + R
Sbjct: 203 DIYTRTSSARLPVKWMPPESLLYGQSSSASDVWSYGIVLWEIFTIGDSPYPGVKSKGIPR 262
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
L +G R+ KPP D LY VMLRCW + P RP+F EL + + +D +
Sbjct: 263 MLREGYRMPKPPHVGDALYFVMLRCWQEDPDERPTFDELCDNMQALQQDEK 313
Score = 75.8 bits (178), Expect = 6e-12
Identities = 45/126 (35%), Positives = 66/126 (52%), Gaps = 2/126 (1%)
Query: 586 NLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMV 645
N G+D + DE +E P + L+ K+LG+G FG V KA A GI VAVK +
Sbjct: 5 NPGLDAIYSCVGEDEAWEVPPQNLSVIKRLGSGNFGHVDKAMAIGIPGFPGQVTVAVKTL 64
Query: 646 KRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAK--RELIVIVEYCKYGNIHN 703
K TA +EL +M L H ++V L+G CT+ + L +I EY YG++
Sbjct: 65 KATAQEKDKTDFLTELNLMKSLRPHPHVVRLIGCCTRQAGELSNHLAIIFEYLPYGDLLG 124
Query: 704 YMQKHR 709
Y+++ R
Sbjct: 125 YLRRSR 130
>UniRef50_O15146 Cluster: Muscle, skeletal receptor tyrosine protein
kinase precursor; n=53; Euteleostomi|Rep: Muscle,
skeletal receptor tyrosine protein kinase precursor -
Homo sapiens (Human)
Length = 869
Score = 156 bits (379), Expect = 3e-36
Identities = 72/171 (42%), Positives = 106/171 (61%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P PL+ L A Q+A GM YL+ RK +H DLA RN L+ ++ VVKI DFGL+R++Y+
Sbjct: 694 PPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSA 753
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
+ Y+ EN +P++W+ E + ++T+SDVW+YG+VLWE+FS PY ++ +++
Sbjct: 754 DYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIY 813
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
++ DGN L P LYN+M CW + P RPSFT + IL E E
Sbjct: 814 YVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCERAE 864
Score = 62.1 bits (144), Expect = 9e-08
Identities = 34/104 (32%), Positives = 56/104 (53%), Gaps = 4/104 (3%)
Query: 603 EFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELK 662
E+PR + + + +G GAFG V++A A G++ E T VAVKM+K A E
Sbjct: 569 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAA 628
Query: 663 IMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
+M + NIV LLG C + + ++ EY YG+++ +++
Sbjct: 629 LMAEF-DNPNIVKLLGVCA---VGKPMCLLFEYMAYGDLNEFLR 668
Score = 50.4 bits (115), Expect = 3e-04
Identities = 56/228 (24%), Positives = 98/228 (42%), Gaps = 18/228 (7%)
Query: 151 QNITIRNATKKHNGVYTCLLTNTCGEEKDEFRKIFLE-KPFLSLRDLAKGKLMGNANKSI 209
Q +TI + +G+Y C N G + + ++ KP ++ R K++ +
Sbjct: 82 QLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKIT-RPPINVKIIEGLKAVL 140
Query: 210 NIVIEIEAYPPVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVA 269
P V ++K D L N + L +G LRI++++ D Y VA
Sbjct: 141 PCTTMGNPKPSVS---WIKGDSPLRENS---RIAVLESGS--LRIHNVQKEDAGQYRCVA 192
Query: 270 ENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRLE-NSEMNFACKVTGYPLPDVTWIFSNDE 328
+N T Y+ +++ + A++L + S + C TG P+P +TWI E
Sbjct: 193 KNSLGTA-YSKVVKLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITWI----E 247
Query: 329 EHELSSTKSEQESLYAKT--DYLKISVQASGVITCNAHNSKGEYFDSS 374
S+ S QES+ + L++ + G+ TC A N GE F ++
Sbjct: 248 NGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTA 295
Score = 47.6 bits (108), Expect = 0.002
Identities = 27/94 (28%), Positives = 48/94 (51%), Gaps = 10/94 (10%)
Query: 427 DIELLAPIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVD 486
++E+ A I+R P+S+ G + LHC A G+P PTI W ++ +S+ S +
Sbjct: 207 EVEVFARILRAPESHN---VTFGSFVTLHCTATGIPVPTITWIENGNAVSSGS----IQE 259
Query: 487 IVNHTIVNSTFEIENMQEKDNGIYECVALNNASE 520
V +++S ++ + G+Y C+A N E
Sbjct: 260 SVKDRVIDSRLQLFITKP---GLYTCIATNKHGE 290
Score = 46.4 bits (105), Expect = 0.005
Identities = 32/102 (31%), Positives = 49/102 (48%), Gaps = 13/102 (12%)
Query: 431 LAPIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNH 490
+ P I P N + +EG L C G P+P++ W K D + NS +
Sbjct: 119 MKPKITRPPINV--KIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAV------- 169
Query: 491 TIVNSTFEIENMQEKDNGIYECVALNNASELRRAYTLVLKAE 532
+ + + I N+Q++D G Y CVA N+ L AY+ V+K E
Sbjct: 170 -LESGSLRIHNVQKEDAGQYRCVAKNS---LGTAYSKVVKLE 207
>UniRef50_O02466 Cluster: Insulin-like peptide receptor precursor (EC
2.7.10.1) (ILP receptor) [Contains: Insulin-like peptide
receptor alpha chain; Insulin-like peptide receptor beta
chain]; n=4; Eukaryota|Rep: Insulin-like peptide receptor
precursor (EC 2.7.10.1) (ILP receptor) [Contains:
Insulin-like peptide receptor alpha chain; Insulin-like
peptide receptor beta chain] - Branchiostoma lanceolatum
(Common lancelet) (Amphioxus)
Length = 1363
Score = 156 bits (379), Expect = 3e-36
Identities = 92/247 (37%), Positives = 137/247 (55%), Gaps = 14/247 (5%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
P T ++ A IA GM YLA +K +H DLA RN ++A D VKI DFG+ R +Y +
Sbjct: 1119 PPTFKDIIQMAGVIADGMSYLAAKKFVHRDLACRNCMVAQDRTVKIGDFGMTRDIYETDY 1178
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
Y+K LPV+W++ E + +F++QSDVWSYG+VLWEM +LA PY S ++L+++
Sbjct: 1179 YRKGGKGLLPVRWMSPESLKVGVFTSQSDVWSYGVVLWEMATLASQPYQGKSNEEVLKFV 1238
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLED--NERNRYVDLNA 973
DG LEKP ++LY++M CW + + RP+F E+ EIL L+ NE + Y L+
Sbjct: 1239 IDGGMLEKPEGCPNKLYDLMKLCWQYRQSMRPTFLEIVEILSPELQAHFNEVSFYHSLD- 1297
Query: 974 PYNEMNAELMTGEDYLAMVCAPDYNNIVTPSPNYVNMAKSFFPATPTPKDQEGYLPMSPT 1033
+ E+ D +A+ D + PS S F +TP+P + Y M+ +
Sbjct: 1298 NHGREPLEM----DDVALDSGADTETEMYPS-------GSEFSSTPSPPSETPYSHMNGS 1346
Query: 1034 SDQTKYM 1040
Q M
Sbjct: 1347 HPQNGSM 1353
Score = 71.7 bits (168), Expect = 1e-10
Identities = 40/127 (31%), Positives = 70/127 (55%), Gaps = 4/127 (3%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+++E PREK+T ++LG G+FG+VY+ EA+ ++ E VAVK V +A +
Sbjct: 985 DEWEVPREKITLIRELGQGSFGMVYEGEAKDVVKDEPMVSVAVKTVNESASIRERIEFLN 1044
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDN 719
E +M H ++V L+G +K + +V++E G++ NY+++HR L+D+
Sbjct: 1045 EASVMKTFNCH-HVVKLMGVVSK---GQPTLVVMELMALGDLKNYLRRHRPEEDVGLSDS 1100
Query: 720 AEKNLGK 726
N K
Sbjct: 1101 PASNEAK 1107
>UniRef50_UPI0000D55B96 Cluster: PREDICTED: similar to
Tyrosine-protein kinase Src64B (Dsrc64) isoform 2; n=1;
Tribolium castaneum|Rep: PREDICTED: similar to
Tyrosine-protein kinase Src64B (Dsrc64) isoform 2 -
Tribolium castaneum
Length = 473
Score = 156 bits (378), Expect = 4e-36
Identities = 80/188 (42%), Positives = 114/188 (60%), Gaps = 3/188 (1%)
Query: 774 YIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLL 833
YI QE+ +K + + L L+ AFQ+A GMEYL +++++H DLAARNVL+
Sbjct: 274 YIVQEYMSKGSLLDFLRKDEGKELEFEDLVYIAFQVASGMEYLESKQLIHRDLAARNVLI 333
Query: 834 ADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLW 893
++N+ KICDFGLAR + +N EY K+ S PVKW A E +V FS +SDVWSYGI L
Sbjct: 334 GENNIAKICDFGLARVIEDN-EYCPKQGSRFPVKWTAPEAIVYGKFSIKSDVWSYGIFLM 392
Query: 894 EMFSLAKTPYPNISPTDLLRWLSDGNRLEKPP--FADDRLYNVMLRCWHQKPTARPSFTE 951
E+F+ + PYP + +++ + G R+ KP D +Y++ML+CW KP RP+F
Sbjct: 393 ELFTYGQVPYPGMHGREVIDMVEKGYRMGKPTSHVLPDEIYSIMLQCWDAKPENRPTFEF 452
Query: 952 LQEILGNF 959
L F
Sbjct: 453 LTHYFEGF 460
>UniRef50_Q4H3N2 Cluster: Epidermal growth factor receptor; n=1; Ciona
intestinalis|Rep: Epidermal growth factor receptor -
Ciona intestinalis (Transparent sea squirt)
Length = 878
Score = 156 bits (378), Expect = 4e-36
Identities = 88/272 (32%), Positives = 139/272 (51%), Gaps = 3/272 (1%)
Query: 799 SGHLLGWAFQIARGMEYLANRK-VLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQ 857
S HLL W+ QIA+GM+YL+ K ++H DLAARNVL+ N V+I DFGLA+ + E+
Sbjct: 225 SQHLLNWSLQIAKGMKYLSEEKHLVHRDLAARNVLVKSPNHVRITDFGLAKLLDVKEDVY 284
Query: 858 KKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSD 917
+ E +P+KWLA+E + RIF+ +SDVWS+G+ +WE+ + K PY ++ ++ L
Sbjct: 285 RAEGGKMPIKWLALESIQHRIFTQKSDVWSFGVTMWELMTFGKKPYESVPAREVHTLLER 344
Query: 918 GNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLNAPYNE 977
G RL +P +Y ++++CW ARP+F EL E L D +R +D + +
Sbjct: 345 GERLPQPYICTIDIYMLLIKCWTVDAEARPTFKELTEELSKLARDPQRYLVIDNDGLLTD 404
Query: 978 MNAELMTGEDYLAMVCAPDYNNIVTPSPNYVNMAKSFFPATPTPKDQEGYLPMSPTSDQT 1037
+ + T E ++V + +T + Y++ P +Q P+ PT
Sbjct: 405 LPSP-TTSEFLRSLVNDEGDDFPITDAEEYLHPQPLEGTENPLNSNQFSLQPV-PTMVPW 462
Query: 1038 KYMAHGTKFDFDSRKLNPRVSEASNVGSVITP 1069
K H S + S S G + P
Sbjct: 463 KRQHHQQHLSSTSSQQGLLGSRGSGSGRFVHP 494
Score = 44.4 bits (100), Expect = 0.018
Identities = 36/155 (23%), Positives = 76/155 (49%), Gaps = 12/155 (7%)
Query: 562 KKQRELTKAGLLNFKSGNKKSFNPNLGIDEQ---ADLLPYDEKFEFPRE-KLTFGKQLGA 617
K+ + + K G+ + S +++ +P + + E + + P + +E +L GK LG+
Sbjct: 73 KRTQSMRKLGI-DPHSPEEQNMDPRVRLMEPMTPSGVAPNQAQLRIVKEAELRIGKILGS 131
Query: 618 GAFGVVYKAEARGII--NAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVN 675
GAFG V+K + V PVA+K+++ + + + E +M +H N+V
Sbjct: 132 GAFGTVHKGYWIPDLAPRERVKVPVAIKVLRDESSQVASNEILDEAFVMASC-EHPNLVR 190
Query: 676 LLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHRE 710
LLG + +++I + GN+ Y++ +++
Sbjct: 191 LLGIS----LSQRIMLITQLMPLGNLLEYVRDNKD 221
>UniRef50_UPI000065F6B2 Cluster: Receptor tyrosine-protein kinase
erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine
kinase-type cell surface receptor HER4).; n=1; Takifugu
rubripes|Rep: Receptor tyrosine-protein kinase erbB-4
precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine
kinase-type cell surface receptor HER4). - Takifugu
rubripes
Length = 1236
Score = 155 bits (377), Expect = 5e-36
Identities = 76/180 (42%), Positives = 106/180 (58%), Gaps = 2/180 (1%)
Query: 786 DYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFG 845
DY++E H+ + S LL W QIA+GM YL R+++H DLAARNVL+ N +KI DFG
Sbjct: 758 DYVHE-HKDN-IGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFG 815
Query: 846 LARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN 905
LAR + NE+ + + +KW+A+EC+ R F+ QSDVWSYG+ +WE+ + PY
Sbjct: 816 LARLLDVNEKEYNADGGKMAIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDG 875
Query: 906 ISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNER 965
IS D+ L G RL +PP +Y VM++CW +RP F EL D +R
Sbjct: 876 ISTRDIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFTRMARDPQR 935
Score = 41.1 bits (92), Expect = 0.17
Identities = 31/107 (28%), Positives = 50/107 (46%), Gaps = 6/107 (5%)
Query: 613 KQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVN 672
K LG+GAFG VYK +V PVAVK++ E IM + +H +
Sbjct: 674 KVLGSGAFGTVYKG-IWVPEGEKVKIPVAVKILNEATGPKANVEFMDEALIMASM-EHPH 731
Query: 673 IVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDN 719
+V LLG C + ++ + +G + +Y+ +H++ QL N
Sbjct: 732 LVRLLGVCLSPTIQ----LVTQLMPHGCLLDYVHEHKDNIGSQLLLN 774
>UniRef50_Q4RWP2 Cluster: Tyrosine-protein kinase receptor; n=1;
Tetraodon nigroviridis|Rep: Tyrosine-protein kinase
receptor - Tetraodon nigroviridis (Green puffer)
Length = 1419
Score = 155 bits (377), Expect = 5e-36
Identities = 74/184 (40%), Positives = 112/184 (60%), Gaps = 4/184 (2%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
P T ++ A +IA GM YL +K +H DLAARN ++ D VKI DFG+ R +Y +
Sbjct: 1166 PPTLKEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVGHDFTVKIGDFGMTRDIYETDY 1225
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
Y+K LPV+W+A E + D +F+ SD WS+G+VLWE+ +L++ PY +S +L+++
Sbjct: 1226 YRKGGKGLLPVRWMAPESLKDGVFTAHSDCWSFGVVLWEISTLSEQPYQGLSNEQVLKFV 1285
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLNAPY 975
DG L++P DRLYN+M CW P RP+F E+ E+ L D+ + D++ Y
Sbjct: 1286 MDGGYLDRPDNCPDRLYNLMQMCWQYNPKMRPTFLEIIEM----LHDDLHPSFQDVSFFY 1341
Query: 976 NEMN 979
+E N
Sbjct: 1342 SEEN 1345
Score = 52.4 bits (120), Expect = 7e-05
Identities = 35/101 (34%), Positives = 54/101 (53%), Gaps = 5/101 (4%)
Query: 575 FKSGNKKSFNPNLGIDEQ--ADLLP--YDE-KFEFPREKLTFGKQLGAGAFGVVYKAEAR 629
+ S N + + N G+ E A +P Y+E ++E PREK++ ++LG G FG+VY+ A+
Sbjct: 971 YASSNPEYLSANDGVTESGVAVNVPAVYEEDEWEVPREKISILRELGQGTFGMVYEGLAK 1030
Query: 630 GIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKH 670
II E T VAVK V +A+ +E +M H
Sbjct: 1031 DIIKGEGETHVAVKTVNESANLRQRIEFLNEASVMKAFSCH 1071
>UniRef50_Q5TRF2 Cluster: ENSANGP00000025511; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000025511 - Anopheles gambiae
str. PEST
Length = 693
Score = 155 bits (377), Expect = 5e-36
Identities = 74/142 (52%), Positives = 98/142 (69%), Gaps = 1/142 (0%)
Query: 790 ECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARS 849
E P P SG LL ++ QIA GME+LA KV+H DLAARNVL+ D N VKI DFGL+R
Sbjct: 553 EKEDPLP-NSGQLLEFSRQIALGMEFLARNKVVHRDLAARNVLVCDSNTVKIADFGLSRD 611
Query: 850 MYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPT 909
+Y Y+K N LP+KWLA+E M +++++QSDVWSYGI+L+E+ +L +PYP IS
Sbjct: 612 IYQENLYRKTSNGKLPIKWLALESMTHQVYTSQSDVWSYGILLYEICTLGGSPYPAISTN 671
Query: 910 DLLRWLSDGNRLEKPPFADDRL 931
LLR+L G R+E+P + L
Sbjct: 672 RLLRYLESGYRMERPKSCSELL 693
Score = 64.9 bits (151), Expect = 1e-08
Identities = 38/131 (29%), Positives = 69/131 (52%), Gaps = 11/131 (8%)
Query: 595 LLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYI 654
+ P +++ E E + LG GAFG+V K G++ AVKM+K I
Sbjct: 329 IAPINDELEIEMEHIKLHDMLGEGAFGLVRK----GVLQR-----TAVKMLKECPRVEDI 379
Query: 655 KALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFID 714
E+++M +G H +IV ++G CTK++ R+++++ EYC GN+ NY++ + +
Sbjct: 380 LEFRREMEVMKSVGTHPHIVGIVGHCTKNV--RKMMLLTEYCGRGNLLNYLRLQWQRLLR 437
Query: 715 QLTDNAEKNLG 725
Q +++G
Sbjct: 438 QNRTTGTRSIG 448
>UniRef50_UPI0000DB6DD4 Cluster: PREDICTED: similar to Insulin-like
growth factor 1 receptor precursor (Insulin-like growth
factor I receptor) (IGF-I receptor); n=1; Apis
mellifera|Rep: PREDICTED: similar to Insulin-like growth
factor 1 receptor precursor (Insulin-like growth factor
I receptor) (IGF-I receptor) - Apis mellifera
Length = 855
Score = 155 bits (376), Expect = 7e-36
Identities = 68/155 (43%), Positives = 101/155 (65%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
+L A +IA GM YL+ +K +H DLAARN ++A+D VK+ DFG+ R +Y + Y+K
Sbjct: 441 ILQMAIEIADGMAYLSTKKFVHRDLAARNCMVAEDLTVKVGDFGMTRDIYERDYYRKGSK 500
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
LPV+W+A E + D +FS+ SDVWSYG+VLWEM + A PY +S +LR++ +G +
Sbjct: 501 GLLPVRWMAPESLKDGVFSSYSDVWSYGVVLWEMVTFASQPYQGLSNEQVLRYVIEGGVM 560
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEIL 956
E+P + LY +M R W K T RP+F ++ +L
Sbjct: 561 ERPENCPELLYELMKRTWRHKATRRPTFMDIASML 595
Score = 60.1 bits (139), Expect = 3e-07
Identities = 34/110 (30%), Positives = 58/110 (52%), Gaps = 4/110 (3%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+++E PREK+ + LG G FG+VY+ A+ I+ + AVK V + A + +
Sbjct: 321 DEWEVPREKIEMLRSLGTGTFGMVYEGIAKDIVKGKSEVRCAVKTVNKDATDRERIEFLN 380
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
E +M H ++V LLG T+ + +VI+E G++ Y++ HR
Sbjct: 381 EASVMKGFDAH-HVVKLLGVVTR---GQPTLVIMELMVNGDLKRYLRSHR 426
>UniRef50_Q8IQ00 Cluster: CG3277-PB, isoform B; n=3; Sophophora|Rep:
CG3277-PB, isoform B - Drosophila melanogaster (Fruit
fly)
Length = 808
Score = 155 bits (376), Expect = 7e-36
Identities = 73/178 (41%), Positives = 117/178 (65%), Gaps = 12/178 (6%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLAR-SMYNNEE 855
L + L +A QIA GM +L +++ H DLAARNVL+ + +KI DFGL+R +Y N
Sbjct: 627 LDNKELHNFALQIANGMRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLSRHGIYTNTR 686
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
+K LP++WL+IE + + ++S++SD+W+YG+VLWE+ +L +PYP IS +L+ +L
Sbjct: 687 TRK-----LPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTISNDELIPFL 741
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLNA 973
GNRLE+P ++Y +ML+CW ++P RP+F L ++L + + YVD+N+
Sbjct: 742 MAGNRLERPEICTPQVYTIMLQCWLEEPEERPTFDALYKVL------SPKTTYVDINS 793
Score = 70.1 bits (164), Expect = 3e-10
Identities = 38/120 (31%), Positives = 66/120 (55%), Gaps = 3/120 (2%)
Query: 591 EQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTAD 650
+++ +L + FE P + G+ LG GAFG V++A A + TT VAVK +K
Sbjct: 406 QKSQVLGLADIFEVPHSAIQIGRMLGEGAFGQVHEATAINLRRMRGTTIVAVKQLKPNPK 465
Query: 651 NMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHRE 710
+ +E++++ +G H N+V+ LG CT K ++I+EY GN+ +Y++ R+
Sbjct: 466 ADEVAEYLAEIEMLKGVGTHHNVVSFLGCCT---IKPPYLMIMEYVNKGNLLSYLRTVRK 522
>UniRef50_Q9Y1Z0 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 485
Score = 154 bits (374), Expect = 1e-35
Identities = 66/160 (41%), Positives = 106/160 (66%), Gaps = 4/160 (2%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
+T + + +A + +GM YL ++ +H DLAARNVL+A+DNV K+ DFGLA+S N
Sbjct: 320 ITKQNQIDFARDVVKGMVYLESQNFVHRDLAARNVLIAEDNVAKVSDFGLAKSSSN---- 375
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
K+E + LPVKW A E + + FS ++DVWS+G++LWE++S + PYP + D+ +
Sbjct: 376 VKQEGAKLPVKWTAPEALRENKFSNKTDVWSFGVLLWEIYSYGRVPYPRVPVEDVANHVE 435
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEIL 956
+G R+E P D++Y +M+ CW + P+ RP+FT +++ L
Sbjct: 436 NGYRMESPDGCPDQIYKIMMDCWEKDPSQRPNFTRIEKAL 475
>UniRef50_A7SE14 Cluster: Predicted protein; n=4; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 311
Score = 154 bits (374), Expect = 1e-35
Identities = 77/193 (39%), Positives = 123/193 (63%), Gaps = 8/193 (4%)
Query: 773 GYIQQEWQTKYEGDYIYECHQPRP---LTSGHLLGWAFQIARGMEYLANRKVLHGDLAAR 829
GY+++ ++ E D Y + +P L+S L+ +A+Q+A GM+YL+++K++H DLAAR
Sbjct: 104 GYLRK---SRGEEDSYYPDPEIKPKTSLSSQQLVRFAWQVADGMQYLSSQKIIHRDLAAR 160
Query: 830 NVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMV-DRIFSTQSDVWSY 888
N+L+ + V K+ DFG+A+ + N + Y + LPVKW AIE ++ ++TQSDVWS+
Sbjct: 161 NILVGEGEVCKVTDFGMAKDVQNEDIYIRTTEGRLPVKWTAIEALIGGGEYTTQSDVWSF 220
Query: 889 GIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPS 948
G+VL+E+ ++ PYP I+ D+ +L G R+ P D LY +M CW P RP+
Sbjct: 221 GVVLYEICTIGGEPYPGIAGKDIPEYLEAGYRMSCPTHLDATLYEIMASCWATCPDMRPT 280
Query: 949 FTELQEILGNFLE 961
FT L+++L N LE
Sbjct: 281 FTSLEKLL-NTLE 292
Score = 60.5 bits (140), Expect = 3e-07
Identities = 35/112 (31%), Positives = 61/112 (54%), Gaps = 4/112 (3%)
Query: 599 DEKFEFPREKLTFGKQLGAGAFGVVYKAEARGI-INAEVTTPVAVKMVKRTADNMYIKAL 657
D ++ PRE++ K +G GAFG V+K G+ N+ T VA+K A + + L
Sbjct: 2 DPQWTVPRERIHIMKVIGNGAFGQVHKGRVHGLGTNSPGWTLVAIKSPYADASDAETRDL 61
Query: 658 ASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
E +++ L H +++ LLG C + + +VI+EY +G++ Y++K R
Sbjct: 62 MKEFELLKRLKSHPHVIKLLG-CGEDDGRP--LVIIEYVPHGDLLGYLRKSR 110
>UniRef50_Q15303 Cluster: Receptor tyrosine-protein kinase erbB-4
precursor; n=58; Euteleostomi|Rep: Receptor
tyrosine-protein kinase erbB-4 precursor - Homo sapiens
(Human)
Length = 1308
Score = 154 bits (374), Expect = 1e-35
Identities = 74/180 (41%), Positives = 106/180 (58%), Gaps = 2/180 (1%)
Query: 786 DYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFG 845
+Y++E H+ + S LL W QIA+GM YL R+++H DLAARNVL+ N VKI DFG
Sbjct: 806 EYVHE-HKDN-IGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFG 863
Query: 846 LARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN 905
LAR + +E+ + +P+KW+A+EC+ R F+ QSDVWSYG+ +WE+ + PY
Sbjct: 864 LARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDG 923
Query: 906 ISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNER 965
I ++ L G RL +PP +Y VM++CW +RP F EL D +R
Sbjct: 924 IPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQR 983
Score = 41.5 bits (93), Expect = 0.13
Identities = 34/110 (30%), Positives = 51/110 (46%), Gaps = 12/110 (10%)
Query: 613 KQLGAGAFGVVYKAEARGIINAE---VTTPVAVKMVKRTADNMYIKALASELKIMVHLGK 669
K LG+GAFG VYK GI E V PVA+K++ T E IM +
Sbjct: 722 KVLGSGAFGTVYK----GIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASM-D 776
Query: 670 HVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDN 719
H ++V LLG C + ++ + +G + Y+ +H++ QL N
Sbjct: 777 HPHLVRLLGVCLSPTIQ----LVTQLMPHGCLLEYVHEHKDNIGSQLLLN 822
>UniRef50_Q9Y1X9 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 573
Score = 153 bits (372), Expect = 2e-35
Identities = 74/177 (41%), Positives = 107/177 (60%), Gaps = 4/177 (2%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
+L A Q++RGM YL + +H DLAARNVL+ DD+ VKI DFG++R++ EY K E
Sbjct: 388 ILNMALQVSRGMAYLEEVRFVHRDLAARNVLVVDDDNVKISDFGMSRAIGAGSEYYKAET 447
Query: 862 SPL-PVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNR 920
+ P+KW A EC+ F ++SDVWSYG+ +WE FS PY + D+++ L R
Sbjct: 448 AGRWPLKWYAPECIYYAKFDSKSDVWSYGVTVWEAFSFGAKPYAGLKGQDIMQMLEGNQR 507
Query: 921 LEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGN---FLEDNERNRYVDLNAP 974
L+ P +Y++MLRCW +P RPSF+EL +L + +L+ N+ DL P
Sbjct: 508 LDSPEKCPQPIYDIMLRCWAWRPEDRPSFSELSSMLKDIYVYLQQNDTVVSNDLKKP 564
>UniRef50_P00533 Cluster: Epidermal growth factor receptor precursor;
n=124; root|Rep: Epidermal growth factor receptor
precursor - Homo sapiens (Human)
Length = 1210
Score = 153 bits (372), Expect = 2e-35
Identities = 83/238 (34%), Positives = 132/238 (55%), Gaps = 7/238 (2%)
Query: 786 DYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFG 845
DY+ E H+ + S +LL W QIA+GM YL +R+++H DLAARNVL+ VKI DFG
Sbjct: 800 DYVRE-HKDN-IGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFG 857
Query: 846 LARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN 905
LA+ + E+ E +P+KW+A+E ++ RI++ QSDVWSYG+ +WE+ + PY
Sbjct: 858 LAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDG 917
Query: 906 ISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNER 965
I +++ L G RL +PP +Y +M++CW +RP F EL D +
Sbjct: 918 IPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQ- 976
Query: 966 NRYVDLNAPYNEMNAELMTGED-YLAMVCAPDYNNIVTPSPNYVNMAKSFFPATPTPK 1022
RY+ + M+ T + Y A++ D +++V + Y+ + FF + T +
Sbjct: 977 -RYLVIQGD-ERMHLPSPTDSNFYRALMDEEDMDDVV-DADEYLIPQQGFFSSPSTSR 1031
Score = 39.1 bits (87), Expect = 0.69
Identities = 28/99 (28%), Positives = 49/99 (49%), Gaps = 8/99 (8%)
Query: 613 KQLGAGAFGVVYKAEARGIINAE-VTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHV 671
K LG+GAFG VYK I E V PVA+K ++ K + E +M + +
Sbjct: 716 KVLGSGAFGTVYK--GLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASV-DNP 772
Query: 672 NIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHRE 710
++ LLG C + +I + +G + +Y+++H++
Sbjct: 773 HVCRLLGICLTSTVQ----LITQLMPFGCLLDYVREHKD 807
>UniRef50_P35590 Cluster: Tyrosine-protein kinase receptor Tie-1
precursor; n=37; Deuterostomia|Rep: Tyrosine-protein
kinase receptor Tie-1 precursor - Homo sapiens (Human)
Length = 1138
Score = 153 bits (371), Expect = 3e-35
Identities = 75/176 (42%), Positives = 111/176 (63%), Gaps = 5/176 (2%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
L+S LL +A A GM+YL+ ++ +H DLAARNVL+ ++ KI DFGL+R E Y
Sbjct: 951 LSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRG---EEVY 1007
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
KK LPV+W+AIE + +++T+SDVWS+G++LWE+ SL TPY ++ +L L
Sbjct: 1008 VKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLP 1067
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLN 972
G R+E+P DD +Y +M +CW +P RP F ++ LG LE R YV+++
Sbjct: 1068 QGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLE--ARKAYVNMS 1121
Score = 64.5 bits (150), Expect = 2e-08
Identities = 37/108 (34%), Positives = 58/108 (53%), Gaps = 6/108 (5%)
Query: 607 EKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVH 666
E +TF +G G FG V +A + + A+KM+K A + A EL+++
Sbjct: 837 EDITFEDLIGEGNFGQVIRAMIK---KDGLKMNAAIKMLKEYASENDHRDFAGELEVLCK 893
Query: 667 LGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFID 714
LG H NI+NLLGAC + L + +EY YGN+ ++++K R + D
Sbjct: 894 LGHHPNIINLLGACKN---RGYLYIAIEYAPYGNLLDFLRKSRVLETD 938
>UniRef50_Q7YZH7 Cluster: MBRTK2; n=1; Monosiga brevicollis|Rep:
MBRTK2 - Monosiga brevicollis
Length = 759
Score = 153 bits (370), Expect = 4e-35
Identities = 79/179 (44%), Positives = 110/179 (61%), Gaps = 6/179 (3%)
Query: 786 DYIYECH----QPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKI 841
DY+ +C +P+ L S L + QIA GM +L + V+H DLAARNVLL+ KI
Sbjct: 450 DYLRKCRTSQSKPQLLGSRQLADFCLQIASGMSFLERKNVIHRDLAARNVLLSQSLACKI 509
Query: 842 CDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKT 901
CDFGLARS+ NE+Y+ LPVKW+A E + RI++++SDVWS+G+ +WE+FSL T
Sbjct: 510 CDFGLARSI-ENEDYETTATK-LPVKWMAPESLGYRIYTSKSDVWSFGVTMWEIFSLGGT 567
Query: 902 PYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFL 960
PY D+L L+DG RL KP A + + CW + RP+F EL ++L F+
Sbjct: 568 PYVKHRNVDILSLLADGYRLPKPRQAPGQADAIARMCWMHEADNRPTFLELVDLLTAFI 626
Score = 53.6 bits (123), Expect = 3e-05
Identities = 33/108 (30%), Positives = 56/108 (51%), Gaps = 4/108 (3%)
Query: 602 FEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASEL 661
+E R + G++LG GAFG V++A + E + A K +K A + SE+
Sbjct: 353 WEVERRSVRLGEKLGNGAFGQVFRAWFCNRHSGEERS-CAAKALKPGAPFRARQDFLSEM 411
Query: 662 KIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+M +G H NI+ + G C + I++VE + GN+ +Y++K R
Sbjct: 412 TVMKEIGAHPNIIGIFGHC---LRDEPHILLVELAELGNLRDYLRKCR 456
>UniRef50_Q6SAJ2 Cluster: Epidermal growth factor receptor; n=11;
Diptera|Rep: Epidermal growth factor receptor -
Drosophila melanogaster (Fruit fly)
Length = 1325
Score = 153 bits (370), Expect = 4e-35
Identities = 64/164 (39%), Positives = 103/164 (62%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
LL W+ QIA+GM YL ++++H DLAARNVL+ ++VKI DFGLA+ + ++ K
Sbjct: 939 LLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAG 998
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
+P+KWLA+EC+ +R+F+++SDVW++G+ +WE+ + + P+ NI D+ + G +L
Sbjct: 999 GKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKL 1058
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNER 965
E+P +Y +L CWH RP+F +L + F D R
Sbjct: 1059 EQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGR 1102
>UniRef50_Q6SAA3 Cluster: Epidermal growth factor receptor; n=39;
Drosophila melanogaster|Rep: Epidermal growth factor
receptor - Drosophila melanogaster (Fruit fly)
Length = 1325
Score = 153 bits (370), Expect = 4e-35
Identities = 64/164 (39%), Positives = 103/164 (62%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
LL W+ QIA+GM YL ++++H DLAARNVL+ ++VKI DFGLA+ + ++ K
Sbjct: 939 LLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAG 998
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
+P+KWLA+EC+ +R+F+++SDVW++G+ +WE+ + + P+ NI D+ + G +L
Sbjct: 999 GKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKL 1058
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNER 965
E+P +Y +L CWH RP+F +L + F D R
Sbjct: 1059 EQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGR 1102
>UniRef50_Q4H3N3 Cluster: Epidermal growth factor receptor; n=1; Ciona
intestinalis|Rep: Epidermal growth factor receptor -
Ciona intestinalis (Transparent sea squirt)
Length = 1462
Score = 153 bits (370), Expect = 4e-35
Identities = 70/169 (41%), Positives = 99/169 (58%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
+ S +L W QIA+GM+YL + ++H DLAARNVL+ N VKI DFGLA+ + EE
Sbjct: 939 IRSRQILSWCVQIAKGMKYLEEKHLVHRDLAARNVLVKTPNHVKITDFGLAKMLDTKEEI 998
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
E LP+KWLAIEC+ +R FS SDVW++G+ WE+ + PY + D+L L
Sbjct: 999 YHAEGGKLPIKWLAIECITEREFSHLSDVWAFGVTCWELLTFGARPYEGVRAVDVLSLLE 1058
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNER 965
G+RL +P + +Y V+++CW RPSF+ L + D R
Sbjct: 1059 RGDRLPQPATSTIDIYMVLVKCWMVDRLCRPSFSNLVDEFSKMAADPSR 1107
>UniRef50_P04412 Cluster: Epidermal growth factor receptor precursor;
n=129; Endopterygota|Rep: Epidermal growth factor
receptor precursor - Drosophila melanogaster (Fruit fly)
Length = 1426
Score = 153 bits (370), Expect = 4e-35
Identities = 64/164 (39%), Positives = 103/164 (62%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
LL W+ QIA+GM YL ++++H DLAARNVL+ ++VKI DFGLA+ + ++ K
Sbjct: 1040 LLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAG 1099
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
+P+KWLA+EC+ +R+F+++SDVW++G+ +WE+ + + P+ NI D+ + G +L
Sbjct: 1100 GKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKL 1159
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNER 965
E+P +Y +L CWH RP+F +L + F D R
Sbjct: 1160 EQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGR 1203
Score = 37.5 bits (83), Expect = 2.1
Identities = 30/104 (28%), Positives = 51/104 (49%), Gaps = 8/104 (7%)
Query: 608 KLTFGKQLGAGAFGVVYKAEARGIINAE-VTTPVAVKMVKRTADNMYIKALASELKIMVH 666
+L G LG GAFG VYK + E V PVA+K + ++ + E IM
Sbjct: 937 ELRKGGVLGMGAFGRVYKGV--WVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMAS 994
Query: 667 LGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHRE 710
+HVN++ LL C ++++I + G + +Y++ +R+
Sbjct: 995 -EEHVNLLKLLAVC----MSSQMMLITQLMPLGCLLDYVRNNRD 1033
>UniRef50_Q4RZA4 Cluster: Chromosome 1 SCAF14944, whole genome
shotgun sequence; n=9; Actinopteri|Rep: Chromosome 1
SCAF14944, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 1094
Score = 152 bits (369), Expect = 5e-35
Identities = 106/318 (33%), Positives = 162/318 (50%), Gaps = 51/318 (16%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIK 655
LPYD +E R+ L G+ LG+GAFG V +A A G+++++ + VAVKM+K +
Sbjct: 573 LPYDLAWEMSRDNLVLGRTLGSGAFGRVVEATAYGLMHSQSSIKVAVKMLKSRESET--Q 630
Query: 656 ALASELKIMVHLGKHVNIVNLLGACTKHIAKREL-------------------------I 690
AL SELKIM HLG H+NIVNLL ACTKH + L
Sbjct: 631 ALMSELKIMSHLGPHLNIVNLLAACTKHGEVKNLHQLCQYHVHEYSHNTIVSPNQSGPLY 690
Query: 691 VIVEYCKYGNIHNYMQKHREVFIDQLTDNAEKNLGKINKGFLNSVGTT--GTHSDYFSSG 748
++ EYC+YG++ +Y+ +++ F+ D + + G L S G+T Y S G
Sbjct: 691 LVTEYCRYGDLVDYLHRNKHTFLQYYLDKNQ------DGGSLISGGSTPLSQRKGYVSFG 744
Query: 749 NTKD-------TDHSLLYSGNSKRSGRKVSEGYIQQEWQTKYEGDYIYECHQPR------ 795
+ D D +Y +++ + + Y+ D E R
Sbjct: 745 SESDGGYMDMSKDEPAVYVPMQEQTDAIKYADIQPSPYDSPYQQDIYQEQGGGRVDLVIS 804
Query: 796 ---PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYN 852
LT LLG+++Q+A+GME+LA++ +H DLAARNVL+ + +VKICDFGLAR + +
Sbjct: 805 DSPALTYDDLLGFSYQVAKGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMH 864
Query: 853 NEEYQKKENSPLPVKWLA 870
+ Y K + +P+ +A
Sbjct: 865 DSNYISKGSVSVPISVMA 882
Score = 108 bits (260), Expect = 8e-22
Identities = 48/117 (41%), Positives = 72/117 (61%), Gaps = 1/117 (0%)
Query: 864 LPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLL-RWLSDGNRLE 922
LP+KW+A E + +++T SDVWSYGI+LWE+F+L TPYP++ +L L G R+
Sbjct: 908 LPLKWMAPESIFHNLYTTLSDVWSYGILLWEIFTLGGTPYPDLPMNELFYSALKRGYRMA 967
Query: 923 KPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLNAPYNEMN 979
KP A D +Y +M RCW + RP F+ L +GN L D + +Y ++N + + N
Sbjct: 968 KPAHASDEVYEIMKRCWDETFEKRPDFSFLVHCVGNMLTDGYKKKYREVNETFLKSN 1024
Score = 59.7 bits (138), Expect = 5e-07
Identities = 75/361 (20%), Positives = 142/361 (39%), Gaps = 31/361 (8%)
Query: 5 VVPRDCSKIVIECRPTTPDVNVTLSSEIPDYYYPSFRYSPKIGFVPENSMPSDDQIISFV 64
+VP + + + C T P++ VTL + S + +VP + + ++V
Sbjct: 131 MVPMNREESTVPCLVTNPNIRVTLHDK-------DTGLSIEGVYVPGEGFKAYLEYRTYV 183
Query: 65 LCEFVRGETR-IEKYIYVSKHIKKPPKPKVAGGHKQFLEGETFTIHCRVPNDGLINFKWK 123
+ GE + + Y S H+ + V +GE T++C V L+NF W
Sbjct: 184 CRGELNGEVKESQPYNVYSVHVPEDIDAYVNASKTVLKQGEPLTVNCTVQGVELVNFSWV 243
Query: 124 YPPEVTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEE--KDEF 181
P + + + + + T +V+ +AT H+G Y C +
Sbjct: 244 IPNRDSVGAQPQTDIISATTMRSCLVFP-----HATVAHSGTYVCRAVEGIQNQATNASI 298
Query: 182 RKIFLEKPFLSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDKYLPSNDLKYN 241
LEK F++++ K + +++ + +E+EAYPP + K D +K +
Sbjct: 299 NISVLEKGFVAVKSTQKQNITAKHQENVELRVEMEAYPPPQ--ILWKKD----GATVKAD 352
Query: 242 VTTLANGDPKLR-INDLKLTDIAN-----YTLVAENKYLTKNYTVDLRVFTKPEAKLLNN 295
T + + ++R + L L + + YT++ N+ K L V + K L +
Sbjct: 353 RTIVIRQEHEIRYVTILTLVRVRSEQKGLYTVLITNEDDRKEVAFALEVQIPAQVKDLTD 412
Query: 296 RIIKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYLKISVQA 355
L ++ C G P P + W S D + S+ + + L A + L I
Sbjct: 413 H---HLPGNKHLVTCVAEGVPTPVIQW-RSCDRMLKCSNQSALWQLLTADPELLSIQTNV 468
Query: 356 S 356
+
Sbjct: 469 T 469
>UniRef50_Q9XYS4 Cluster: Tyrosine kinase receptor HTK32; n=1; Hydra
vulgaris|Rep: Tyrosine kinase receptor HTK32 - Hydra
attenuata (Hydra) (Hydra vulgaris)
Length = 752
Score = 152 bits (369), Expect = 5e-35
Identities = 71/173 (41%), Positives = 108/173 (62%), Gaps = 2/173 (1%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
LL +++QIA GM++LA +++H DLA RN+ L + V KI ++GL R +Y Y+K
Sbjct: 548 LLSFSWQIASGMKHLAGLQIVHRDLACRNIYLGHEKVCKISEYGLTRDIYAENVYRKNTG 607
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPT-DLLRWLSDGNR 920
LPV+W+A E + + +++ +SDVWS+GI+LWE+ SL K PYP I T +LL L G
Sbjct: 608 GQLPVRWMAYEAIFESLYTEKSDVWSFGILLWELISLGKIPYPEIIRTEELLDVLESGYH 667
Query: 921 LEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLNA 973
+E P Y +M CW++ P RPSF+ L + L F+ D + +V+LN+
Sbjct: 668 MENPGHISTDFYLLMNSCWNKAPENRPSFSSLVKKLAEFMNDKD-EMHVNLNS 719
Score = 50.0 bits (114), Expect = 4e-04
Identities = 56/253 (22%), Positives = 105/253 (41%), Gaps = 17/253 (6%)
Query: 129 TNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEKDEFRKIFLEK 188
TN + ++ K T + + + + I N GVYTC + N + + L
Sbjct: 42 TNVTWPITWSKVNGVVTNNNIGKLVII-NMKASDAGVYTCKVQNPLNSMESSDKSFTLHY 100
Query: 189 -PFLSLRDLAKG-KLMGNANKSINIVIEIEAYPPVERTHF--LKNDKYLPSNDLKYNVTT 244
L ++ K +++ N N S I P ++ +F LK+ + + N+
Sbjct: 101 VDSLKWIEIPKSSEVIANQNFSWTASI----ISPSDKINFVWLKDGNIMEKIKSEENIEG 156
Query: 245 LANGDPKLRINDLKLTDIANYTLVAENKYLTK-NYTVDLRVFTKPEAKLLNNRIIKRLEN 303
A +L ++ + D Y ++ EN ++ Y + L+V + P ++ + IK E
Sbjct: 157 -AKYSSRLLFKNISIEDFGKYRVIVENMVISGVAYDMSLKVKSAPYVEIEDGTEIKVKEG 215
Query: 304 SEMNFACKVTGYPLPDVTWIFSN---DEEHELSSTKSEQESLYAKTDYLKISVQASGVIT 360
++ C V YP+P ++W + E + S+K+E Y +K ++ V
Sbjct: 216 ESISITCLVNAYPIPFISWSKNETIISIEKKPISSKNEWRFKYVLP--IK-KLKKKNVFV 272
Query: 361 CNAHNSKGEYFDS 373
C +NS G F S
Sbjct: 273 CTGNNSIGSSFAS 285
Score = 46.0 bits (104), Expect = 0.006
Identities = 25/101 (24%), Positives = 52/101 (51%), Gaps = 3/101 (2%)
Query: 609 LTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLG 668
+ F + LG+G +G V + + V++KM+ A + + +EL++M +
Sbjct: 428 IVFDEILGSGEYGHVSGGRIIDEGDPNMCKDVSIKMLHDNASAETYRDMLNELRMMRRVS 487
Query: 669 KHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+H N+++L+G C I + L V+ EY +G + +++ R
Sbjct: 488 RHPNVISLIGWC---ITDQNLYVLEEYAPFGCLLTFLRTQR 525
>UniRef50_A3EXK6 Cluster: Fibroblast growth factor receptor c; n=2;
Nematostella vectensis|Rep: Fibroblast growth factor
receptor c - Nematostella vectensis
Length = 297
Score = 152 bits (369), Expect = 5e-35
Identities = 67/155 (43%), Positives = 103/155 (66%), Gaps = 1/155 (0%)
Query: 806 AFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLP 865
A +A+GM+YLA+++ +H DLAARNVL+AD V K+ DFGL+R++Y EY+K LP
Sbjct: 141 ALDVAQGMDYLASKRCVHRDLAARNVLIAD-GVAKVADFGLSRNIYETGEYEKTTRGKLP 199
Query: 866 VKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPP 925
+W+++E + R F+ +SDVWSYG++LWE+ + TP ++ +++ G RLE+PP
Sbjct: 200 TRWMSLESLETRKFTLESDVWSYGVLLWEIETRGLTPNAGLNYREMIARYRKGYRLERPP 259
Query: 926 FADDRLYNVMLRCWHQKPTARPSFTELQEILGNFL 960
D LY +M RCW P +RP+F+++ E L L
Sbjct: 260 DCDQGLYEIMRRCWLAIPKSRPTFSDIVEQLTELL 294
Score = 57.2 bits (132), Expect = 2e-06
Identities = 34/105 (32%), Positives = 56/105 (53%), Gaps = 5/105 (4%)
Query: 605 PREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIM 664
P + + LG+G FGVV + E + T AVK +K A ++ L EL++M
Sbjct: 12 PTSNIILHEYLGSGEFGVVTRGEMT--TDDGRTVDCAVKSIKGFASEEALRDLVQELELM 69
Query: 665 VHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+G H N++NL+GACT +L++IVE+ G + + + + R
Sbjct: 70 HSVGHHRNLLNLIGACTD---SEKLMIIVEFANDGCLLDLLHQAR 111
>UniRef50_Q9PVZ4 Cluster: Insulin receptor precursor (EC 2.7.10.1)
(IR) (Xe-InsR) (XTK-1b) [Contains: Insulin receptor
subunit alpha; Insulin receptor subunit beta]; n=6;
Euteleostomi|Rep: Insulin receptor precursor (EC
2.7.10.1) (IR) (Xe-InsR) (XTK-1b) [Contains: Insulin
receptor subunit alpha; Insulin receptor subunit beta] -
Xenopus laevis (African clawed frog)
Length = 1362
Score = 152 bits (369), Expect = 5e-35
Identities = 72/182 (39%), Positives = 114/182 (62%), Gaps = 4/182 (2%)
Query: 798 TSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQ 857
T ++ A +I+ GM YL +K +H DLAARN ++ADD VKI DFG+ R +Y + Y+
Sbjct: 1121 TLKEIIQMAAEISDGMAYLNAKKFVHRDLAARNCMVADDYAVKIGDFGMTRDIYETDYYR 1180
Query: 858 KKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSD 917
K LPV+W++ E + D +F+ SDVWS+G+VLWE+ SLA+ PY +S +L+++ D
Sbjct: 1181 KGGKGLLPVRWMSPESLKDGVFTAFSDVWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMD 1240
Query: 918 GNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLNAPYNE 977
G L+ P RL+++M CW P RP+F E+ ++ L+D+ R + D++ Y++
Sbjct: 1241 GGSLDHPENCPPRLHSLMQMCWQYNPKMRPTFLEIIDM----LKDDLRPSFQDVSFYYSD 1296
Query: 978 MN 979
N
Sbjct: 1297 EN 1298
Score = 60.9 bits (141), Expect = 2e-07
Identities = 46/163 (28%), Positives = 78/163 (47%), Gaps = 12/163 (7%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+++E PR+K+ ++LG G+FG+VY+ A+ II E VAVK V +A +
Sbjct: 1003 DEWEVPRDKINLLRELGQGSFGMVYEGIAKDIIKGEPEVRVAVKTVNESASLRERIEFLN 1062
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDN 719
E +M H ++V LLG +K + +VI+E +G++ +Y++ L +
Sbjct: 1063 EASVMKAFNCH-HVVRLLGVVSK---GQPTLVIMELMAHGDLKSYLR--------SLRPD 1110
Query: 720 AEKNLGKINKGFLNSVGTTGTHSDYFSSGNTKDTDHSLLYSGN 762
AE N G++ + SD + N K H L + N
Sbjct: 1111 AENNPGRLAPTLKEIIQMAAEISDGMAYLNAKKFVHRDLAARN 1153
>UniRef50_P08922 Cluster: Proto-oncogene tyrosine-protein kinase ROS
precursor; n=20; Eumetazoa|Rep: Proto-oncogene
tyrosine-protein kinase ROS precursor - Homo sapiens
(Human)
Length = 2347
Score = 152 bits (368), Expect = 6e-35
Identities = 74/168 (44%), Positives = 105/168 (62%), Gaps = 5/168 (2%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLA-----DDNVVKICDFGLARSMY 851
LT L+ I++G YL +H DLAARN L++ +VKI DFGLAR +Y
Sbjct: 2051 LTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIY 2110
Query: 852 NNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDL 911
N+ Y+K+ LPV+W+A E ++D IF+TQSDVWS+GI++WE+ +L PYP S D+
Sbjct: 2111 KNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDV 2170
Query: 912 LRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNF 959
L ++ G RLE P D L+N+M +CW Q+P RP+F +Q+ L F
Sbjct: 2171 LNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLF 2218
Score = 53.6 bits (123), Expect = 3e-05
Identities = 40/119 (33%), Positives = 58/119 (48%), Gaps = 9/119 (7%)
Query: 596 LPYDEKFE----FPREKLTFGKQLGAGAFGVVYKAEARGIIN-AEVTTPVAVKMVKRTAD 650
LP E+ E FPREKLT LG+GAFG VY+ A I+ VAVK +K+ +
Sbjct: 1928 LPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGST 1987
Query: 651 NMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ E +M H NI+ LG C + +I+E + G++ Y++K R
Sbjct: 1988 DQEKIEFLKEAHLMSKF-NHPNILKQLGVC---LLNEPQYIILELMEGGDLLTYLRKAR 2042
>UniRef50_P00534 Cluster: Tyrosine-protein kinase transforming
protein erbB; n=8; root|Rep: Tyrosine-protein kinase
transforming protein erbB - Avian leukosis virus (ALV)
Length = 634
Score = 152 bits (368), Expect = 6e-35
Identities = 71/167 (42%), Positives = 104/167 (62%), Gaps = 2/167 (1%)
Query: 786 DYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFG 845
DYI E H+ + S +LL W QIA+GM YL R+++H DLAARNVL+ VKI DFG
Sbjct: 220 DYIRE-HKDN-IGSQYLLNWCVQIAKGMNYLEERRLVHRDLAARNVLVKTPQHVKITDFG 277
Query: 846 LARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN 905
LA+ + +E+ E +P+KW+A+E ++ RI++ QSDVWSYG+ +WE+ + PY
Sbjct: 278 LAKLLGADEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDG 337
Query: 906 ISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTEL 952
I +++ L G RL +PP +Y +M++CW +RP F EL
Sbjct: 338 IPASEISSVLEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFREL 384
Score = 40.7 bits (91), Expect = 0.23
Identities = 29/99 (29%), Positives = 49/99 (49%), Gaps = 8/99 (8%)
Query: 613 KQLGAGAFGVVYKAEARGIINAE-VTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHV 671
K LG+GAFG VYK I E V PVA+K ++ K + E +M + +
Sbjct: 136 KVLGSGAFGTVYK--GLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASV-DNP 192
Query: 672 NIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHRE 710
++ LLG C + +I + YG + +Y+++H++
Sbjct: 193 HVCRLLGICLTSTVQ----LITQLMPYGCLLDYIREHKD 227
>UniRef50_P08069 Cluster: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (Insulin-like growth factor I
receptor) (IGF-I receptor) (CD221 antigen) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain]; n=47;
Euteleostomi|Rep: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (Insulin-like growth factor I
receptor) (IGF-I receptor) (CD221 antigen) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain] - Homo
sapiens (Human)
Length = 1367
Score = 151 bits (366), Expect = 1e-34
Identities = 74/184 (40%), Positives = 113/184 (61%), Gaps = 4/184 (2%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
P + ++ A +IA GM YL K +H DLAARN ++A+D VKI DFG+ R +Y +
Sbjct: 1106 PPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDY 1165
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
Y+K LPV+W++ E + D +F+T SDVWS+G+VLWE+ +LA+ PY +S +LR++
Sbjct: 1166 YRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV 1225
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLNAPY 975
+G L+KP D L+ +M CW P RPSF EI+ + E+ E + +++ Y
Sbjct: 1226 MEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFL---EIISSIKEEMEPG-FREVSFYY 1281
Query: 976 NEMN 979
+E N
Sbjct: 1282 SEEN 1285
Score = 65.3 bits (152), Expect = 9e-09
Identities = 47/159 (29%), Positives = 81/159 (50%), Gaps = 13/159 (8%)
Query: 551 GMVAYLFTWKLKKQRELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLT 610
G+V L+ + K+ G+L + S N + F+ AD+ DE +E REK+T
Sbjct: 950 GLVIMLYVFHRKRNNSRLGNGVL-YASVNPEYFSA-------ADVYVPDE-WEVAREKIT 1000
Query: 611 FGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKH 670
++LG G+FG+VY+ A+G++ E T VA+K V A +E +M H
Sbjct: 1001 MSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCH 1060
Query: 671 VNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
++V LLG ++ + +VI+E G++ +Y++ R
Sbjct: 1061 -HVVRLLGVVSQ---GQPTLVIMELMTRGDLKSYLRSLR 1095
>UniRef50_Q4H3B8 Cluster: Tyrosine-protein kinase receptor; n=1;
Ciona intestinalis|Rep: Tyrosine-protein kinase receptor
- Ciona intestinalis (Transparent sea squirt)
Length = 465
Score = 151 bits (365), Expect = 1e-34
Identities = 69/155 (44%), Positives = 98/155 (63%)
Query: 808 QIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVK 867
+IA GM YL+ K +H DLAARN L+ +D VKI DFGL R +Y + Y+ LPV+
Sbjct: 217 EIADGMSYLSETKYVHRDLAARNCLVHEDLTVKIGDFGLTRDVYETDYYRIDSRGILPVR 276
Query: 868 WLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFA 927
W+A E + D +F ++SDVWS+GIVLWE+ +LA+ PY + R++ DG +E+P
Sbjct: 277 WMAPESLKDGVFDSRSDVWSFGIVLWEIATLAEQPYQGQQHDQVTRFVIDGGYMEQPKEC 336
Query: 928 DDRLYNVMLRCWHQKPTARPSFTELQEILGNFLED 962
+LY++ML CWH P+ RP+F E+ L L D
Sbjct: 337 PSKLYDMMLMCWHYSPSMRPTFLEIVASLSPDLSD 371
Score = 50.0 bits (114), Expect = 4e-04
Identities = 30/110 (27%), Positives = 55/110 (50%), Gaps = 4/110 (3%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+++E P E + ++G G FG VY+ A+ ++ + T VAVK +
Sbjct: 90 DEYEIPEENVELMDEIGHGHFGKVYEGLAKQVVKGQPKTKVAVKTLHGNESISKRMEFLK 149
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
E +M H ++V LLG + ++KR + VI+E+ G++ Y++ R
Sbjct: 150 EASVMKAFNSH-HVVRLLGVVS--MSKRPM-VIMEFMAKGDLKTYLRSTR 195
>UniRef50_O76385 Cluster: Putative uncharacterized protein; n=3;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 903
Score = 151 bits (365), Expect = 1e-34
Identities = 79/209 (37%), Positives = 124/209 (59%), Gaps = 4/209 (1%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
+T LL +A QI+ G+EYL+ + +H D+AARNVL+ + KI DFGL R +Y ++
Sbjct: 682 VTLKQLLQFAVQISYGLEYLSQKGFVHRDVAARNVLVHEGTACKIGDFGLCRYIYADQSQ 741
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
K + LP+KW++ E + FS +SD+WS+GI+L+E+ +L +PYP + P D+L +L
Sbjct: 742 YKSKGGKLPLKWMSPEAIRHYEFSIKSDIWSFGILLFEVITLGGSPYPGMPPEDVLPFLE 801
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLED-NERNRYVDLNAPY 975
G R+EKP + Y+VM++CW+ P R F++++ L LED E Y+ L+A
Sbjct: 802 GGGRIEKPDNCPENFYDVMMQCWNADPDDRIEFSDVRMQLATQLEDITEDYSYLKLDAAK 861
Query: 976 NEMNAELMTGEDYLAMVCAPDYNNIVTPS 1004
+ N + E +V PD I+ PS
Sbjct: 862 DYYNVQ-YGDEKKTDVVIIPD--EIIKPS 887
Score = 50.8 bits (116), Expect = 2e-04
Identities = 34/109 (31%), Positives = 55/109 (50%), Gaps = 17/109 (15%)
Query: 613 KQLGAGAFGVVY--KAEARGIINAEVTTP------------VAVKMVKRTADNMYIKALA 658
K+LG+GAFG VY K + + + + +P VAVKM+ AD M
Sbjct: 547 KKLGSGAFGAVYLGKLIGKSLAHKDANSPLGINLMRAENCQVAVKMLPEYADEMSKHEFL 606
Query: 659 SELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQK 707
E+ +M LG H +VN+L T+ L ++VEYC G++ ++++
Sbjct: 607 REIALMKTLGYHERLVNMLACVTE---SEPLCLVVEYCDNGDLLKFLRE 652
>UniRef50_Q8AXY6 Cluster: Muscle, skeletal receptor tyrosine protein
kinase precursor; n=18; Gnathostomata|Rep: Muscle,
skeletal receptor tyrosine protein kinase precursor -
Gallus gallus (Chicken)
Length = 947
Score = 151 bits (365), Expect = 1e-34
Identities = 67/156 (42%), Positives = 99/156 (63%)
Query: 806 AFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLP 865
A Q+A GM YL+ RK +H DLA RN L+ ++ VVKI DFGL+R+MY+ + Y+ EN +P
Sbjct: 784 AKQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNMYSADYYKANENDAIP 843
Query: 866 VKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPP 925
++W+ E + ++T+SDVW+YG+VLWE+FS PY ++ +++ ++ DGN L P
Sbjct: 844 IRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGMQPYYGMAHEEVIYYVRDGNILSCPD 903
Query: 926 FADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
LYN+M CW + P RPSF + IL E
Sbjct: 904 NCPLELYNLMRLCWSKLPADRPSFASIHRILERMYE 939
Score = 63.7 bits (148), Expect = 3e-08
Identities = 35/104 (33%), Positives = 56/104 (53%), Gaps = 4/104 (3%)
Query: 603 EFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELK 662
E+PR + + + +G GAFG V++A A G++ E T VAVKM+K A E
Sbjct: 649 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAA 708
Query: 663 IMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
+M + NIV LLG C + + ++ EY YG+++ Y++
Sbjct: 709 LMAEF-DNPNIVKLLGVCA---VGKPMCLLFEYMAYGDLNEYLR 748
Score = 42.3 bits (95), Expect = 0.074
Identities = 28/101 (27%), Positives = 47/101 (46%), Gaps = 11/101 (10%)
Query: 431 LAPIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNH 490
+ P I P N E +EG L C G P+P++ W K + ++ N+ +
Sbjct: 119 MRPKITRPPVNV--EIIEGLKAVLPCTTMGNPKPSVSWIKGETVVKENARIAV------- 169
Query: 491 TIVNSTFEIENMQEKDNGIYECVALNN-ASELRRAYTLVLK 530
+ + I N+Q +D G Y CVA N+ S + T+V++
Sbjct: 170 -LDSGNLRIHNVQREDAGQYRCVAKNSLGSAYSKPATVVVE 209
Score = 41.5 bits (93), Expect = 0.13
Identities = 54/255 (21%), Positives = 103/255 (40%), Gaps = 17/255 (6%)
Query: 124 YP-PEVT--NDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEKDE 180
YP PE+T +S+ + + T + + Q +TI + +GVY C N G
Sbjct: 54 YPEPEITWTRNSIPIRLFDTRYSIQRN--GQLLTILSVEDSDDGVYCCTADNGVGAAAQS 111
Query: 181 FRKIFLEKPFLSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDKYLPSNDLKY 240
+ ++ R +++ + P V ++K + + N
Sbjct: 112 CGALQVKMRPKITRPPVNVEIIEGLKAVLPCTTMGNPKPSVS---WIKGETVVKENA--- 165
Query: 241 NVTTLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAKLLNNRIIKR 300
+ L +G+ LRI++++ D Y VA+N L Y+ V + A++L +
Sbjct: 166 RIAVLDSGN--LRIHNVQREDAGQYRCVAKNS-LGSAYSKPATVVVEVFARILKAPESQN 222
Query: 301 LE-NSEMNFACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYLKISVQASGVI 359
+ S + C G P+P VTW+ + S +S ++ + L++ V G+
Sbjct: 223 ITFGSMVTLRCTAAGAPVPTVTWLENGKAVSAGSIAESVKDRVV--DSRLQVYVTRPGLF 280
Query: 360 TCNAHNSKGEYFDSS 374
TC A N + F ++
Sbjct: 281 TCLATNKHSKTFGAA 295
Score = 39.9 bits (89), Expect = 0.40
Identities = 24/93 (25%), Positives = 46/93 (49%), Gaps = 10/93 (10%)
Query: 428 IELLAPIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDI 487
+E+ A I++ P+S + G + L C A G P PT+ W ++ + +S S +
Sbjct: 208 VEVFARILKAPES---QNITFGSMVTLRCTAAGAPVPTVTWLENGKAVSAGS----IAES 260
Query: 488 VNHTIVNSTFEIENMQEKDNGIYECVALNNASE 520
V +V+S ++ + G++ C+A N S+
Sbjct: 261 VKDRVVDSRLQVYVTRP---GLFTCLATNKHSK 290
>UniRef50_Q86MD7 Cluster: EGF receptor; n=1; Echinococcus
multilocularis|Rep: EGF receptor - Echinococcus
multilocularis
Length = 1564
Score = 150 bits (364), Expect = 2e-34
Identities = 73/175 (41%), Positives = 107/175 (61%), Gaps = 1/175 (0%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSM-YNNEE 855
L S LL WA QIA GM YL R ++H DLAARNVL+ +V+I DFGLA+ + NNE+
Sbjct: 1113 LNSFTLLSWAEQIADGMAYLEERGIIHRDLAARNVLVQSRELVQITDFGLAKMLDTNNED 1172
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
+P++WLAIE + I+S ++DVWSYG+ LWE+F+ K PY NIS +++ +
Sbjct: 1173 SVVVRTGRVPIRWLAIETLQAGIYSHKTDVWSYGVTLWEIFTFGKQPYENISTSEIKDHV 1232
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVD 970
G RL +P Y VM++CW ++ +RP+F EL + + + R Y++
Sbjct: 1233 MKGVRLSQPEICTLDTYMVMVQCWMEEHESRPTFLELMKCFHKYCQTPGRYLYIE 1287
>UniRef50_Q17LF1 Cluster: Muscle-specific tyrosine kinase receptor;
n=5; Endopterygota|Rep: Muscle-specific tyrosine kinase
receptor - Aedes aegypti (Yellowfever mosquito)
Length = 666
Score = 150 bits (364), Expect = 2e-34
Identities = 69/167 (41%), Positives = 108/167 (64%), Gaps = 4/167 (2%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
L+ G LL A QIA GM YL+ RK +H DLA RN L+ D+ VVKI DFGL+ +Y + Y
Sbjct: 494 LSHGDLLSIASQIASGMVYLSERKFVHRDLATRNCLIDDNMVVKIADFGLSHKIYLQDYY 553
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
+ EN +P++W+ +E ++ ++ +SDVW+YG+ LWE+FS A PY ++ ++++++
Sbjct: 554 KGDENDAIPIRWMPLESILYNKYTIESDVWAYGVCLWEIFSFAMQPYYGMTHEEVVKFVK 613
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPS----FTELQEILGNF 959
+GN L P +Y++M +CW +KP RPS F +LQ+I +F
Sbjct: 614 EGNMLSCPENTPLTVYDLMRKCWSRKPADRPSFPIIFQKLQQIRADF 660
Score = 68.9 bits (161), Expect = 7e-10
Identities = 42/115 (36%), Positives = 62/115 (53%), Gaps = 4/115 (3%)
Query: 593 ADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNM 652
A L P EK EFPR + + K LG GAFG V++A+A G+I E T VAVKM+K A
Sbjct: 367 AQLNPKLEKLEFPRNNIIYIKDLGQGAFGRVFQAKAPGLIAGEDFTLVAVKMLKDEASQD 426
Query: 653 YIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQK 707
E ++ H NIV LLG C R + ++ E+ G+++ ++++
Sbjct: 427 LQVDFEREACLLAEF-DHPNIVKLLGVCA---IGRPMCLLFEFMARGDLNEFLRQ 477
>UniRef50_P00528 Cluster: Tyrosine-protein kinase Src64B; n=6;
Endopterygota|Rep: Tyrosine-protein kinase Src64B -
Drosophila melanogaster (Fruit fly)
Length = 552
Score = 150 bits (364), Expect = 2e-34
Identities = 80/194 (41%), Positives = 119/194 (61%), Gaps = 5/194 (2%)
Query: 774 YIQQEWQTKYEG-DYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVL 832
YI QE+ +K D++ E R L L+ A Q+A GMEYL +++++H DLAARNVL
Sbjct: 353 YIVQEYMSKGSLLDFLRE-GDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVL 411
Query: 833 LADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVL 892
+ ++NV KICDFGLAR + ++EY K+ S PVKW A E ++ FS +SDVWSYGI+L
Sbjct: 412 IGENNVAKICDFGLAR-VIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILL 470
Query: 893 WEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPP--FADDRLYNVMLRCWHQKPTARPSFT 950
E+F+ + PYP + +++ + G R+ KP + D +Y ++L+CW P RP+F
Sbjct: 471 MELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFE 530
Query: 951 ELQEILGNFLEDNE 964
L +F +E
Sbjct: 531 FLNHYFESFSVTSE 544
Score = 38.7 bits (86), Expect = 0.91
Identities = 28/108 (25%), Positives = 54/108 (50%), Gaps = 12/108 (11%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+K+E PR ++ ++LG G FG V+ + R I+ VAVK ++ M A
Sbjct: 275 DKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSID------VAVKTLRE--GTMSTAAFLQ 326
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQK 707
E IM +H +V L C++ + + ++ EY G++ +++++
Sbjct: 327 EAAIMKKF-RHNRLVALYAVCSQ---EEPIYIVQEYMSKGSLLDFLRE 370
>UniRef50_O73798 Cluster: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (xIGF- 1R) (xIGFR) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain]; n=25;
Euteleostomi|Rep: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (xIGF- 1R) (xIGFR) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain] -
Xenopus laevis (African clawed frog)
Length = 1358
Score = 150 bits (364), Expect = 2e-34
Identities = 70/160 (43%), Positives = 100/160 (62%), Gaps = 1/160 (0%)
Query: 793 QPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYN 852
QP P ++ A +IA GM YL K +H DLAARN ++ +D VKI DFG+ R +Y
Sbjct: 1100 QPTPSLK-KMIQMAGEIADGMSYLNANKFVHRDLAARNCMVTEDFTVKIGDFGMTRDIYE 1158
Query: 853 NEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLL 912
+ Y+K LPV+W++ E + D +F+T SDVWS+G+VLWE+ +LA+ PY +S +L
Sbjct: 1159 TDYYRKGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGMSNEQVL 1218
Query: 913 RWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTEL 952
R++ +G LEKP D L+ +M CW P RPSF E+
Sbjct: 1219 RFVMEGGLLEKPDNCPDMLFELMRMCWQFNPKMRPSFLEI 1258
Score = 68.1 bits (159), Expect = 1e-09
Identities = 36/110 (32%), Positives = 62/110 (56%), Gaps = 4/110 (3%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+K+E PREK+T ++LG G+FG+VY+ A+G++ E T VA+K V A +
Sbjct: 986 DKWEVPREKITMNRELGQGSFGMVYEGIAKGVVKDEAETKVAIKTVNEAASMRERIEFLN 1045
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
E +M H ++V LLG ++ + +VI+E G++ +Y++ R
Sbjct: 1046 EASVMKEFNCH-HVVRLLGVVSQ---GQPTLVIMELMTRGDLKSYLRSLR 1091
>UniRef50_Q8MY86 Cluster: Fibroblast growth factor receptor 1
precursor; n=2; Dugesia japonica|Rep: Fibroblast growth
factor receptor 1 precursor - Dugesia japonica
(Planarian)
Length = 854
Score = 150 bits (364), Expect = 2e-34
Identities = 81/198 (40%), Positives = 122/198 (61%), Gaps = 9/198 (4%)
Query: 798 TSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQ 857
TS L ++ QIARGM YLA+R V+H DL+ARN+L+ + +KI DFGL R + + Y+
Sbjct: 662 TSSILCTYSLQIARGMTYLASRSVVHRDLSARNILVGEHFEMKIADFGLTRIV--DYYYR 719
Query: 858 KKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSD 917
KK + LPVKW+A E ++++ ++T+SDVWSYGI+LWE+F+L +PY I P ++ +
Sbjct: 720 KKTDGILPVKWMAPEALLEKKYTTKSDVWSYGILLWEIFTLGDSPYSAILPEKVVDLIRK 779
Query: 918 GNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE--DNERNRYVDLNAPY 975
G + KP A+ +Y +M CW RP+F E+ EIL + ++ D+E N +
Sbjct: 780 GFQNPKPELANFEIYRLMQHCWSLSSENRPNFFEIVEILIDIIQRIDDEPEE----NIYH 835
Query: 976 NEMNAELMTGEDYLAMVC 993
+E+N L DYL C
Sbjct: 836 SELN-YLKMESDYLEPKC 852
Score = 91.5 bits (217), Expect = 1e-16
Identities = 48/111 (43%), Positives = 68/111 (61%), Gaps = 4/111 (3%)
Query: 597 PYDEKFEFPREKLTF-GKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIK 655
P D K+EFPREKL K+LG GAFG+VY+ A I N VAVKM++ + +
Sbjct: 538 PCDAKWEFPREKLKITNKKLGEGAFGMVYEGIANDIGNRSNPIKVAVKMMRDDFSDSNVH 597
Query: 656 ALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
E++IM H+G+H N++ LLG CT+ K L VIVE YGN+ ++++
Sbjct: 598 DFVKEMEIMKHIGRHPNVIQLLGLCTQ---KGPLRVIVELAPYGNLRDFVR 645
>UniRef50_Q21038 Cluster: Putative uncharacterized protein ver-3; n=2;
Caenorhabditis|Rep: Putative uncharacterized protein
ver-3 - Caenorhabditis elegans
Length = 1227
Score = 150 bits (363), Expect = 2e-34
Identities = 67/172 (38%), Positives = 107/172 (62%), Gaps = 2/172 (1%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P L + LL QIA+GM +LA+ +H DLA RNVL+ +V+I DFGL++ N
Sbjct: 999 PDALCTSDLLSIGLQIAKGMAWLADVPCVHRDLACRNVLITKTKIVRIADFGLSKKHTNK 1058
Query: 854 EEYQ--KKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDL 911
Y+ K +++PLPV+W+ +EC+ + F+ +SDVWS+GI L+E+F+L TPYPN ++
Sbjct: 1059 TYYRTKKSKDTPLPVRWMPLECIEEFKFTQKSDVWSFGICLYEIFTLGGTPYPNCDTFNV 1118
Query: 912 LRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
+ ++ +GNR ++P + D +Y +M CW P RP+F + N + D+
Sbjct: 1119 IEFIRNGNRNKQPEYCHDEIYELMKVCWQFNPKDRPTFNDCITFFENHMRDS 1170
Score = 97.9 bits (233), Expect = 1e-18
Identities = 68/282 (24%), Positives = 126/282 (44%), Gaps = 27/282 (9%)
Query: 453 QLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIYEC 512
+++C G P P W+KD ++ VD S + + +D+G + C
Sbjct: 693 EINCNMTGTPPPVYQWFKDGNPYTHGD-----VD-------GSILRVSRARGEDDGEFHC 740
Query: 513 VALNNASELRRAYTLVLKAEKSYTPYXXXXXXXXXXXXGMVAYLFTWKLKKQRELTKAG- 571
+A N A + + + + + + + +L T KL+ LTK
Sbjct: 741 LATNRAGDKLNSIEVQVNNAPKGSLFFYWFLALLLLISIIAVFLLTCKLRASNRLTKQKD 800
Query: 572 ---------LLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGV 622
++ ++G +L ++E+ LPY+ +E L +G+G FGV
Sbjct: 801 IALNTLYETMIKHQAGPLPEEMKDLPVEERTYYLPYNNDYEIDPVNLEILNPIGSGHFGV 860
Query: 623 VYK-----AEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLL 677
V K A + I ++ PVAVK + K +A ELK+M + K+ N++ L+
Sbjct: 861 VKKGLLGMAYPKSKIESKTRLPVAVKSSTNPFNVELQKMMAEELKVMCAIPKNPNVLALI 920
Query: 678 GACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDN 719
GA TK++ + +L ++ E+ GN+ ++Q HR FI++L ++
Sbjct: 921 GAVTKNMRQGQLYIVTEFIDGGNLREFLQAHRNTFINELVED 962
>UniRef50_Q25410 Cluster: Putative molluscan insulin-related
peptide(s) receptor precursor (EC 2.7.10.1) [Contains:
Putative molluscan insulin-related peptide(s) receptor
alpha chain; Putative molluscan insulin-related
peptide(s) receptor beta chain]; n=2; Coelomata|Rep:
Putative molluscan insulin-related peptide(s) receptor
precursor (EC 2.7.10.1) [Contains: Putative molluscan
insulin-related peptide(s) receptor alpha chain; Putative
molluscan insulin-related peptide(s) receptor beta chain]
- Lymnaea stagnalis (Great pond snail)
Length = 1607
Score = 150 bits (363), Expect = 2e-34
Identities = 66/155 (42%), Positives = 103/155 (66%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
+L A +IA GM YLA++K +H DLAARN +++++ VKI DFG+ R +Y + Y+K
Sbjct: 1150 ILQMAGEIADGMAYLADKKFVHRDLAARNCMVSEERTVKIGDFGMTRDIYETDYYRKGGK 1209
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
LPV+W+A E + D +F++ SDVWSYG+V+WEM +LA PY +S ++++++SDG +
Sbjct: 1210 GMLPVRWMAPESLKDGVFTSLSDVWSYGVVMWEMVTLAAQPYQGLSNEEVVKFISDGYIM 1269
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEIL 956
E P + + +M CW +KP RP+F + E L
Sbjct: 1270 ELPENCPNEMAYLMQHCWAKKPNQRPTFKAIIEYL 1304
Score = 56.8 bits (131), Expect = 3e-06
Identities = 37/118 (31%), Positives = 62/118 (52%), Gaps = 5/118 (4%)
Query: 593 ADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGI-INAEVTTPVAVKMVKRTADN 651
+++L +++E R+K+ K+LG G+FG+VY+ A+GI + PVAVK V A
Sbjct: 1021 SEILYISDEWEVDRDKIKLIKELGQGSFGMVYEGVAKGIRDDPNEEIPVAVKTVNDRASF 1080
Query: 652 MYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ E M H ++V LLG + + +VI+E G++ NY++ HR
Sbjct: 1081 SDRREFLKEATTMKEFHCH-HVVKLLGVVS---TGQPALVIMELMALGDLKNYLRGHR 1134
>UniRef50_P06213 Cluster: Insulin receptor precursor (EC 2.7.10.1)
(IR) (CD220 antigen) [Contains: Insulin receptor subunit
alpha; Insulin receptor subunit beta]; n=100;
Euteleostomi|Rep: Insulin receptor precursor (EC
2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin
receptor subunit alpha; Insulin receptor subunit beta] -
Homo sapiens (Human)
Length = 1382
Score = 150 bits (363), Expect = 2e-34
Identities = 68/161 (42%), Positives = 103/161 (63%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
P T ++ A +IA GM YL +K +H DLAARN ++A D VKI DFG+ R +Y +
Sbjct: 1130 PPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDY 1189
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
Y+K LPV+W+A E + D +F+T SD+WS+G+VLWE+ SLA+ PY +S +L+++
Sbjct: 1190 YRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFV 1249
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEIL 956
DG L++P +R+ ++M CW P RP+F E+ +L
Sbjct: 1250 MDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL 1290
Score = 64.1 bits (149), Expect = 2e-08
Identities = 37/110 (33%), Positives = 62/110 (56%), Gaps = 4/110 (3%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+++E REK+T ++LG G+FG+VY+ AR II E T VAVK V +A +
Sbjct: 1014 DEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLN 1073
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
E +M H ++V LLG +K + +V++E +G++ +Y++ R
Sbjct: 1074 EASVMKGFTCH-HVVRLLGVVSK---GQPTLVVMELMAHGDLKSYLRSLR 1119
>UniRef50_P14616 Cluster: Insulin receptor-related protein precursor
(EC 2.7.10.1) (IRR) (IR- related receptor) [Contains:
Insulin receptor-related protein alpha chain; Insulin
receptor-related protein beta chain]; n=14; Eutheria|Rep:
Insulin receptor-related protein precursor (EC 2.7.10.1)
(IRR) (IR- related receptor) [Contains: Insulin
receptor-related protein alpha chain; Insulin
receptor-related protein beta chain] - Homo sapiens
(Human)
Length = 1297
Score = 150 bits (363), Expect = 2e-34
Identities = 73/172 (42%), Positives = 106/172 (61%), Gaps = 1/172 (0%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P+P G ++ A +IA GM YLA K +H DLAARN +++ D VKI DFG+ R +Y
Sbjct: 1085 PQPAL-GEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYET 1143
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
+ Y+K LPV+W+A E + D IF+T SDVWS+G+VLWE+ +LA+ PY +S +L+
Sbjct: 1144 DYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLK 1203
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNER 965
++ DG LE+ +L +M RCW P RPSFT + + + L + R
Sbjct: 1204 FVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQEELRPSFR 1255
Score = 58.8 bits (136), Expect = 8e-07
Identities = 34/110 (30%), Positives = 62/110 (56%), Gaps = 4/110 (3%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+++E PRE+++ ++LG G+FG+VY+ ARG+ E +TPVA+K V A
Sbjct: 970 DEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLK 1029
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
E +M H ++V LLG ++ + +VI+E G++ ++++ R
Sbjct: 1030 EASVMKAFKCH-HVVRLLGVVSQ---GQPTLVIMELMTRGDLKSHLRSLR 1075
>UniRef50_UPI00015B4A8D Cluster: PREDICTED: similar to receptor
tyrosine kinase Flt4; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to receptor tyrosine kinase Flt4 -
Nasonia vitripennis
Length = 682
Score = 149 bits (362), Expect = 3e-34
Identities = 115/385 (29%), Positives = 186/385 (48%), Gaps = 44/385 (11%)
Query: 599 DEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTP---VAVKMVKRTA-DNMYI 654
DE E +L ++LG G FG VY A N ++ VAVKM T+ D+ +
Sbjct: 319 DEAHEISYSRLRIVRELGQGQFGKVYLANLLDSENGSSSSSSSLVAVKMSSLTSSDSARV 378
Query: 655 KA-----LASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L E+ I G H ++V L+G CT + ++ + +++EY + G++H+Y+ + R
Sbjct: 379 QLDVRQQLLEEIAITKVAGSHPHLVGLVGCCT--LPEQPVCLVLEYMRGGDLHSYLHRMR 436
Query: 710 EVFIDQLTDNAEKNLGKINKGFLNSVGTTGTHSDYFSSGNTKDTDHSLLYSGNSKRSGRK 769
E +A + + ++SV T T SL S + R
Sbjct: 437 EAL------DAANDASPLESPGVSSVAET--------------TCTSLGSQSPSTPTSRV 476
Query: 770 VSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAAR 829
I+ + T + + P++ ++ +A +IA+GME L R ++H DLAAR
Sbjct: 477 FFPNEIKADEATNFRSE--------GPISHAEMMRFALEIAKGMEQLEARGIVHRDLAAR 528
Query: 830 NVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYG 889
NVL+ ++ V+KI DFGL+R LP++W+ E + R F+++SDVWSYG
Sbjct: 529 NVLMDENLVLKISDFGLSRK--GTYTLGVNGTRRLPIRWMPPEAIRRRAFTSKSDVWSYG 586
Query: 890 IVLWEMFSLAKTPYPNISPTDLL-RWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPS 948
+VLWE+ SL PY +S LL L + R E A D + +M CW +P RP+
Sbjct: 587 VVLWEIASLGDFPYARLSDDALLCHLLEENGRPELLEEASDEMSEIMDTCWALRPEQRPN 646
Query: 949 FTELQEILGNFLEDNERNR--YVDL 971
F ++ + + E +N Y+DL
Sbjct: 647 FKQIVAWIESKRELARKNNPVYMDL 671
>UniRef50_P34925 Cluster: Tyrosine-protein kinase RYK precursor;
n=37; Euteleostomi|Rep: Tyrosine-protein kinase RYK
precursor - Homo sapiens (Human)
Length = 604
Score = 149 bits (362), Expect = 3e-34
Identities = 69/172 (40%), Positives = 106/172 (61%)
Query: 788 IYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLA 847
+ E + P+ ++ L+ A QIA GM YLA R+V+H DLAARN ++ D VKI D L+
Sbjct: 425 LVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALS 484
Query: 848 RSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS 907
R ++ + + +N PV+W+A+E +V+ FS+ SDVW++G+ LWE+ +L +TPY +I
Sbjct: 485 RDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDID 544
Query: 908 PTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNF 959
P ++ +L DG R+ +P D L+ VM CW P RP F +L + L F
Sbjct: 545 PFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEF 596
>UniRef50_UPI0000DB6D22 Cluster: PREDICTED: similar to Alk CG8250-PA;
n=1; Apis mellifera|Rep: PREDICTED: similar to Alk
CG8250-PA - Apis mellifera
Length = 1436
Score = 149 bits (361), Expect = 4e-34
Identities = 66/173 (38%), Positives = 104/173 (60%), Gaps = 3/173 (1%)
Query: 793 QPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDN---VVKICDFGLARS 849
+P L L+ F +A G +Y+ + +H D+AARN LL +VKI DFG+A+
Sbjct: 987 RPTSLRMQDLIMCGFDVANGCKYMEEARFIHRDIAARNCLLTSKGPGRIVKIADFGMAKD 1046
Query: 850 MYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPT 909
+Y ++ Y+K + LP+KW+ E +D IF+T++DVW++G++LWE+ S PY +
Sbjct: 1047 IYRSDYYRKGGKAMLPIKWMPPESFLDGIFTTKTDVWAFGVLLWEIMSFGYIPYTGCTNR 1106
Query: 910 DLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLED 962
+ + ++ G RLEKP D +Y +M RCWH +P RPSF + E +G L+D
Sbjct: 1107 EAMTMVTLGGRLEKPAGCPDPIYGLMTRCWHPRPEDRPSFATIVERIGYCLQD 1159
Score = 50.4 bits (115), Expect = 3e-04
Identities = 38/127 (29%), Positives = 61/127 (48%), Gaps = 8/127 (6%)
Query: 583 FNPNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAV 642
FNPN + +L + + + PRE +T + LG GAFG V++ R N E PVAV
Sbjct: 864 FNPNY--EFAGNLYSFKDLTQIPRECITLIRPLGQGAFGEVFQGVYRYRRNQE--QPVAV 919
Query: 643 KMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIH 702
K + ++ E IM H NIV+ +G + K +++E GN+
Sbjct: 920 KAIPSSSRPQTEADFMMEALIMSKF-NHPNIVHFIGVSFERNPK---YIVLELLAGGNLK 975
Query: 703 NYMQKHR 709
N++++ R
Sbjct: 976 NFLREER 982
>UniRef50_UPI0000D57520 Cluster: PREDICTED: similar to CG8250-PA; n=1;
Tribolium castaneum|Rep: PREDICTED: similar to CG8250-PA
- Tribolium castaneum
Length = 1284
Score = 149 bits (361), Expect = 4e-34
Identities = 81/253 (32%), Positives = 140/253 (55%), Gaps = 14/253 (5%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDN---VVKICDFGLARSMYN 852
PLT L+ A +A+G +YL + + +H D+AARN LL VVKI DFG++R +Y
Sbjct: 924 PLTMKDLVLIAVDVAKGCKYLEDNRFIHRDIAARNCLLTTKGPGRVVKIADFGMSRDVYR 983
Query: 853 NEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLL 912
++ Y+K + LP+KW+ E +D IF++++DVWS+G++LWE+ S+ PY + +++
Sbjct: 984 SDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGVLLWEIMSMGYMPYTGCANREVM 1043
Query: 913 RWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE-RNRYVDL 971
+ ++ G RL+ P +Y +M +CWH P RP+F + E LG L+D + N + +
Sbjct: 1044 QLVTSGGRLDPPANCPGPIYGIMTQCWHPTPEQRPTFATILERLGYCLQDPQVMNAPLPV 1103
Query: 972 --NAPYNEMNAELM--TGEDYLAMVCAPDYNNIVTPSPNYVNMAKSFFPATPTPKDQEGY 1027
P NE +A +M D + P ++ + PN+ N++ ++ K
Sbjct: 1104 FNRPPSNERDATVMRPLSSDENCLQVVPQSSDYLI--PNHTNVSNPIGSSSSVEK----L 1157
Query: 1028 LPMSPTSDQTKYM 1040
LP + S +T ++
Sbjct: 1158 LPENSDSWETSFI 1170
Score = 51.2 bits (117), Expect = 2e-04
Identities = 34/107 (31%), Positives = 51/107 (47%), Gaps = 4/107 (3%)
Query: 603 EFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELK 662
+ PRE+L K LG GAFG VY+ R V PVAVK + + + E
Sbjct: 814 DIPREQLRLVKALGQGAFGEVYQGFYRQRPCDTVEMPVAVKTLPEMSTSQAEMDFLMEAL 873
Query: 663 IMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
IM H NIV+ +G C K +++E G++ N++++ R
Sbjct: 874 IMSKF-NHPNIVHFIGVC---FDKHPRFIVLELLAGGDLKNFLRESR 916
>UniRef50_Q9Y1Y3 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 893
Score = 149 bits (361), Expect = 4e-34
Identities = 74/180 (41%), Positives = 104/180 (57%), Gaps = 1/180 (0%)
Query: 787 YIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGL 846
Y Y H L+ LL A +A GM+YL+ +H DLAARN+L++ D V K+ DFGL
Sbjct: 621 YYYLRHNDEKLSLQQLLKMACGVAAGMQYLSEVGYVHRDLAARNILVSKDEVCKVADFGL 680
Query: 847 ARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNI 906
+R N+EY K+ +PV+W A E + R F+T SDVWSYG++LWE+ S + PY +
Sbjct: 681 SRET-TNDEYDVKKGGKIPVRWTAPEAISYRKFTTASDVWSYGVLLWEVMSYGQQPYEDW 739
Query: 907 SPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERN 966
+L L G RL+KP +Y +M CW + T RP+F EL +L LE N ++
Sbjct: 740 DNQMVLDKLESGYRLQKPKDCPSTVYELMQSCWSAEHTDRPTFKELVRLLDAMLESNNKD 799
Score = 43.6 bits (98), Expect = 0.032
Identities = 30/109 (27%), Positives = 54/109 (49%), Gaps = 9/109 (8%)
Query: 603 EFPREKLTFGKQLGAGAFGVVYKAEARGIIN-AEVTTPVAVKMVKRTADNMYIKALASEL 661
E P + + +++G G FG VYK G+ N + P+AVK +K + + +E
Sbjct: 529 EIPPKYIKLVEEIGGGEFGTVYK----GMWNERKPPVPIAVKTLKPGSSDKMRDDFLTEA 584
Query: 662 KIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHRE 710
IM H N++ L G TK ++I+E+ G+++ Y++ + E
Sbjct: 585 SIMGQF-HHPNVIKLYGVITK---VEPAMIIMEFMDNGSLYYYLRHNDE 629
>UniRef50_P53356 Cluster: Tyrosine-protein kinase HTK16; n=1; Hydra
vulgaris|Rep: Tyrosine-protein kinase HTK16 - Hydra
attenuata (Hydra) (Hydra vulgaris)
Length = 757
Score = 149 bits (361), Expect = 4e-34
Identities = 79/186 (42%), Positives = 107/186 (57%), Gaps = 3/186 (1%)
Query: 786 DYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFG 845
DY+ + +QP + L WA QIA GM YL ++ +H DLAARN+LLA+ VKI DFG
Sbjct: 571 DYLMD-YQPE-IQEVDLKLWASQIAFGMMYLELKRFVHRDLAARNILLANKKQVKISDFG 628
Query: 846 LARSMYNNEEY-QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYP 904
L+R++ +Y Q K+ PV+W A E + FST+SDVWSYGI LWEMF+ PY
Sbjct: 629 LSRAVGTGSDYYQAKQGGRWPVRWYAPESINYGTFSTKSDVWSYGITLWEMFTFGDLPYG 688
Query: 905 NISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
++ +++ +L RLEKP Y++ML CWH P RP+F EL E +
Sbjct: 689 EMTGNEVVSFLEHCGRLEKPDECPIHTYSIMLSCWHIDPNKRPTFNELHSTFSTDPEYED 748
Query: 965 RNRYVD 970
Y D
Sbjct: 749 VRIYRD 754
Score = 37.5 bits (83), Expect = 2.1
Identities = 30/104 (28%), Positives = 49/104 (47%), Gaps = 7/104 (6%)
Query: 606 REKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMV 665
+E ++FGK+LG G FG V K E+ VA+K + + K E +M
Sbjct: 481 KESISFGKELGVGEFGSVIKGIWLSPGGKEIN--VAMKTLHKDKMVQGEKEFLREALVMS 538
Query: 666 HLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
L H IV+LLG C +I++ E + G + +Y+ ++
Sbjct: 539 QL-NHPCIVSLLGVC----LGPPMILVQELVEMGALLDYLMDYQ 577
>UniRef50_Q179Z3 Cluster: Tyrosine-protein kinase; n=1; Aedes
aegypti|Rep: Tyrosine-protein kinase - Aedes aegypti
(Yellowfever mosquito)
Length = 343
Score = 149 bits (360), Expect = 6e-34
Identities = 71/168 (42%), Positives = 107/168 (63%), Gaps = 9/168 (5%)
Query: 805 WAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPL 864
+A QIA GM++L + + H DLAARN+L+ + +KI DFGL+R+ Y N +
Sbjct: 162 FARQIACGMKHLEEKNITHRDLAARNILIDEKKTLKISDFGLSRTGI----YVNTRNKKV 217
Query: 865 PVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKP 924
P++WL+IE M D ++S++SDVW++GIVLWE+ +L PYP +S +LL +L +GNRL++P
Sbjct: 218 PLRWLSIEAMRDHLYSSKSDVWAFGIVLWEIGTLGGYPYPTVSNHELLSFLHNGNRLDRP 277
Query: 925 PFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLN 972
LY +ML CW +P RPSF ++ + L + R Y+D N
Sbjct: 278 ENCSAELYELMLHCWKAEPDDRPSFADIYKSL-----EPHRRIYIDFN 320
Score = 58.8 bits (136), Expect = 8e-07
Identities = 36/100 (36%), Positives = 52/100 (52%), Gaps = 4/100 (4%)
Query: 603 EFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNM-YIKALASEL 661
E P L G+++G GAFG V+ A A + + VAVK +K+ + E+
Sbjct: 34 EVPHSCLRIGREIGKGAFGHVFIANASKLPHCNGPKLVAVKQLKKCPKRKPEFEEFLDEI 93
Query: 662 KIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNI 701
+M +GKH NIV LLG CT K L +I+EY G++
Sbjct: 94 AMMKQVGKHPNIVALLGCCT---LKEPLTMIMEYIGCGDL 130
>UniRef50_Q9V6K3 Cluster: Tyrosine-protein kinase transmembrane
receptor Ror2 precursor; n=2; Sophophora|Rep:
Tyrosine-protein kinase transmembrane receptor Ror2
precursor - Drosophila melanogaster (Fruit fly)
Length = 724
Score = 149 bits (360), Expect = 6e-34
Identities = 66/164 (40%), Positives = 104/164 (63%)
Query: 801 HLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKE 860
HLL A IA GM YL+ RK +H DLA RN L+ + VKI DFGL+ +Y + Y+ E
Sbjct: 556 HLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYYKGDE 615
Query: 861 NSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNR 920
N +P++W+ +E ++ FS +SDVW+YGI LWE+FS A PY ++ ++++++ +GN
Sbjct: 616 NDFIPIRWMPLESILYNKFSLESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNV 675
Query: 921 LEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
L P +Y +M RCW++KP+ RP F E+ + + + ++E
Sbjct: 676 LGCPDNTPLSVYALMRRCWNRKPSERPGFAEINHCIQHSIAESE 719
Score = 61.3 bits (142), Expect = 1e-07
Identities = 35/107 (32%), Positives = 56/107 (52%), Gaps = 4/107 (3%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
EK E+PR + + + LG GAFG V++A A G++ + VAVKM+K A +
Sbjct: 432 EKLEYPRGDIVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFER 491
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
E ++ H NIV LLG C R + ++ EY G++ +++
Sbjct: 492 EACLLAEF-DHPNIVRLLGVCA---LGRPMCLLFEYMAPGDLSEFLR 534
>UniRef50_Q9Y1Y5 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 557
Score = 148 bits (358), Expect = 1e-33
Identities = 70/176 (39%), Positives = 99/176 (56%)
Query: 777 QEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADD 836
+++ K+ G ++ P L+ L I RGM YLA+R+ +H DLAARN LL
Sbjct: 375 KDYLKKHRGPHLQLETYPENLSLQMLKRICVDITRGMSYLADRRFVHRDLAARNCLLDSA 434
Query: 837 NVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMF 896
VK+ DFGL R +Y Y+ + LPVKW+ E + D + ++DVWS+G+ WE+F
Sbjct: 435 LAVKVGDFGLTRDIYLTNYYRAPTETKLPVKWMPPEMLQDGVSDEKTDVWSFGVTCWEVF 494
Query: 897 SLAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTEL 952
S TPYP + +L+ L G RL+KP D +Y +M RCW P RP+F EL
Sbjct: 495 SFGSTPYPGVDNHLMLQHLMSGLRLQKPLLCPDEIYTLMARCWSSNPEDRPTFNEL 550
Score = 48.0 bits (109), Expect = 0.001
Identities = 30/94 (31%), Positives = 49/94 (52%), Gaps = 4/94 (4%)
Query: 616 GAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVN 675
G G+F VY+ + TT VAVK +K + +K+ +E +M L KH N++
Sbjct: 293 GEGSFSKVYRGTLHQMGTG--TTEVAVKAMKSIESDAEMKSFFTECSVMQTL-KHPNVLG 349
Query: 676 LLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+LG C L+V+ + GN+ +Y++KHR
Sbjct: 350 ILGMCFDSPDSIPLMVL-PFMVNGNLKDYLKKHR 382
>UniRef50_Q4S572 Cluster: Tyrosine-protein kinase receptor; n=2;
Tetraodontidae|Rep: Tyrosine-protein kinase receptor -
Tetraodon nigroviridis (Green puffer)
Length = 1331
Score = 147 bits (357), Expect = 1e-33
Identities = 71/161 (44%), Positives = 103/161 (63%), Gaps = 17/161 (10%)
Query: 822 LHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN----------------SPLP 865
+H DLAARNVLL+D+NVVKICDFGLAR +Y + +Y +K + + LP
Sbjct: 1006 IHRDLAARNVLLSDNNVVKICDFGLARDIYKDPDYVRKGDVSSSVPPRRPASGEGLARLP 1065
Query: 866 VKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS-PTDLLRWLSDGNRLEKP 924
+KW++ E + D++F+ QSDVWSYGI+LWE+FSL +PYP + D + L G R+ P
Sbjct: 1066 LKWMSPESIFDKVFTPQSDVWSYGILLWEIFSLGASPYPGLHIDEDFCQRLKAGTRMRAP 1125
Query: 925 PFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNER 965
++ +Y+ ML CW P+ RP+F +L E+LG+ L+ R
Sbjct: 1126 KYSTPDIYSTMLACWEASPSDRPTFADLVEMLGDLLQARVR 1166
Score = 123 bits (296), Expect = 3e-26
Identities = 64/128 (50%), Positives = 88/128 (68%), Gaps = 4/128 (3%)
Query: 589 IDEQADLLPYD-EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKR 647
+++Q + L YD ++EFPRE+L GK LG GAFG V +A A G+ + +T VAVKM+K
Sbjct: 813 VEDQCERLQYDPSQWEFPRERLKLGKPLGCGAFGKVMQASAFGLDSGSCST-VAVKMLKE 871
Query: 648 TADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQK 707
A KAL ELKI+ H+G H+N+VNLLGACTK L+VIVEYC++GN+ +++
Sbjct: 872 GATASEHKALMMELKILNHIGHHLNVVNLLGACTK--PGGPLMVIVEYCRHGNLSAFLKS 929
Query: 708 HREVFIDQ 715
REVF+ Q
Sbjct: 930 KREVFVHQ 937
>UniRef50_Q4RH14 Cluster: Chromosome undetermined SCAF15074, whole
genome shotgun sequence; n=1; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF15074,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 654
Score = 147 bits (357), Expect = 1e-33
Identities = 68/170 (40%), Positives = 104/170 (61%)
Query: 790 ECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARS 849
E + P+ ++ L+ A QIA GM YL+ R+V+H DLAARN ++ D VKI D LAR
Sbjct: 477 EANNPQSVSQQDLVSMAIQIACGMSYLSRREVIHKDLAARNCVIDDSMQVKISDNALARD 536
Query: 850 MYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPT 909
++ + + +N PV+W+A+E ++ FS+ SDVW++G+ LWE+ +L +TPY +I P
Sbjct: 537 LFPMDYHCLGDNENRPVRWMALESLLHNDFSSLSDVWAFGVTLWELMTLGQTPYVDIDPF 596
Query: 910 DLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNF 959
++ +L DG R+ +P D L+ VM CW P RP F +L + L F
Sbjct: 597 EMSAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEF 646
>UniRef50_Q17833 Cluster: Putative uncharacterized protein old-1;
n=2; Caenorhabditis elegans|Rep: Putative
uncharacterized protein old-1 - Caenorhabditis elegans
Length = 502
Score = 147 bits (357), Expect = 1e-33
Identities = 77/192 (40%), Positives = 117/192 (60%), Gaps = 12/192 (6%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKE- 860
LL +AFQIA+GMEYL + +H DLA RNVL+ + +++I DFGLAR + N++Y K +
Sbjct: 298 LLSFAFQIAKGMEYLIHVPCVHRDLALRNVLIKKNRIIRIADFGLAR-RHKNKDYYKTQS 356
Query: 861 -NSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTD--------L 911
++PLP+ W+A E + +F+ +SDVWSYG+ L+E+FSL K+PY N+ D +
Sbjct: 357 VDTPLPIHWMAPESIDKLLFTQKSDVWSYGVCLYELFSLGKSPYENVIKYDQRDFYWKYV 416
Query: 912 LRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDL 971
L +L++G RL +P AD +YNVM CW +R +F + E L+ ++DL
Sbjct: 417 LSYLNEGKRLAQPAHADAEIYNVMKLCWDLDMNSRTTFLDCIEFFEKELKTTSNEYFLDL 476
Query: 972 NAPY-NEMNAEL 982
+E N +L
Sbjct: 477 TRKLRSETNNQL 488
Score = 55.2 bits (127), Expect = 1e-05
Identities = 47/154 (30%), Positives = 80/154 (51%), Gaps = 13/154 (8%)
Query: 577 SGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTF--GKQLGAGAFGVVYKA--EARGII 632
SG K P I+E+ L Y + E E L G+ LG+G FG++ K ++
Sbjct: 144 SGEKLELAP---INEKIMYLHYYAEVEINEEDLDISKGRPLGSGEFGIIRKGFLRSKNSK 200
Query: 633 NAEVTT--PVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELI 690
N E + VAVK+ + + + + ELK+M +GKH NI+ L+G T +R++I
Sbjct: 201 NEEKESRLEVAVKLPLNEYNQIQQELIYDELKVMCAVGKHPNILALVGGIT--FGERKMI 258
Query: 691 VIVEYCKYGNIHNYMQKHREVFI-DQLTDNAEKN 723
V E+ + G++ ++++ +R F DQ T E++
Sbjct: 259 V-SEFVENGDLLSFLRDNRIYFTNDQWTLETEQD 291
>UniRef50_P34892 Cluster: Receptor-like tyrosine-protein kinase
kin-16 precursor; n=1; Caenorhabditis elegans|Rep:
Receptor-like tyrosine-protein kinase kin-16 precursor -
Caenorhabditis elegans
Length = 495
Score = 147 bits (356), Expect = 2e-33
Identities = 69/176 (39%), Positives = 107/176 (60%), Gaps = 3/176 (1%)
Query: 781 TKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVK 840
T DY+ + LT+ LL + QIA GM+YLA+ ++H DLA RNVLL + ++
Sbjct: 278 TDENSDYVIK-ESLDSLTTSDLLSFGLQIANGMQYLASIPMVHRDLALRNVLLKKNKTIR 336
Query: 841 ICDFGLARSMYNNEEY--QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSL 898
I DFG+AR+ N Y QK +++P+PV+W++ E F+ +SDVWS+GI L+E+F+L
Sbjct: 337 IADFGMARTHENKSYYIPQKTKDAPVPVRWMSPEAFDTMKFTEKSDVWSFGICLYEIFTL 396
Query: 899 AKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQE 954
+ PYP++ + ++ G R +P LY++M CWH+KP RP+F+ E
Sbjct: 397 GQLPYPDVPSERIYEYMHSGRRCPQPQHCHVELYDLMKLCWHEKPELRPNFSNCVE 452
Score = 82.6 bits (195), Expect = 6e-14
Identities = 46/139 (33%), Positives = 73/139 (52%), Gaps = 5/139 (3%)
Query: 586 NLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYK-----AEARGIINAEVTTPV 640
N ++++ D LPY +++E E L LG+G FGVV K A + ++ V
Sbjct: 117 NRPLNDKLDYLPYKKQYEIASENLENKSILGSGNFGVVRKGILKMASPKNEEEKKMRLTV 176
Query: 641 AVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGN 700
AVK D LA+EL++M +G+ N++ L+GA T + K L+++ EY G+
Sbjct: 177 AVKSAANCYDISQTSMLAAELRLMCSIGRFPNVLALVGAVTSELRKGRLLIVTEYIDCGD 236
Query: 701 IHNYMQKHREVFIDQLTDN 719
I Y+ HR VF D L ++
Sbjct: 237 IRKYLIDHRNVFQDHLIED 255
>UniRef50_UPI0000D569CE Cluster: PREDICTED: similar to CG10023-PA,
isoform A; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG10023-PA, isoform A - Tribolium castaneum
Length = 1106
Score = 146 bits (354), Expect = 3e-33
Identities = 64/159 (40%), Positives = 101/159 (63%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
LL +AFQ++ + YL ++K +H D+AARNVL++ VK+ DFGL+RSM +++ Y K
Sbjct: 529 LLLYAFQLSTALSYLESKKFVHRDIAARNVLVSSHTSVKLGDFGLSRSMNDDQSYYKASK 588
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
LP+KW++ E + R F+ SDVW +G+ +WE+ P+ + ++L + +G RL
Sbjct: 589 GKLPIKWMSPESINFRRFTIASDVWMFGVCMWEILMYGIKPFQGVKNNEVLTKIENGERL 648
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFL 960
PP RLY++M +CW +P+ RPSF E++EIL L
Sbjct: 649 ALPPNCPPRLYSLMSQCWSYEPSKRPSFKEIKEILNEIL 687
Score = 57.6 bits (133), Expect = 2e-06
Identities = 36/123 (29%), Positives = 63/123 (51%), Gaps = 8/123 (6%)
Query: 589 IDEQADL-LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKR 647
+DE+ D P + +E R+++ G+ LG G FG V+K + + + PVAVK KR
Sbjct: 407 VDEEGDYSTPATKSYELQRDQIQLGEILGEGQFGDVHKGTYKAKDGSLI--PVAVKTCKR 464
Query: 648 TADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQK 707
AD + E IM H +I+ L+G C ++ + +++E K G + Y+Q
Sbjct: 465 EADLNTTEKFLEEAYIMQKF-DHQHIIKLIGVC----SESPVWIVMELAKLGELRAYLQN 519
Query: 708 HRE 710
+++
Sbjct: 520 NKD 522
>UniRef50_Q4TBR4 Cluster: Chromosome undetermined SCAF7099, whole
genome shotgun sequence; n=2; Tetraodontidae|Rep:
Chromosome undetermined SCAF7099, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 1000
Score = 146 bits (354), Expect = 3e-33
Identities = 63/149 (42%), Positives = 97/149 (65%)
Query: 808 QIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVK 867
QIA GM YL+ RK +H DLA RN L+ ++ VVKI DFGL+R++Y+ + Y+ EN +P++
Sbjct: 848 QIAAGMAYLSERKFVHRDLATRNCLVGEEMVVKIADFGLSRNIYSADYYKANENDAIPIR 907
Query: 868 WLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFA 927
W+ E + ++T+SD+W+YG+VLWE+FS PY + +++ ++ DG+ L P
Sbjct: 908 WMPPESIFYNRYTTESDIWAYGVVLWEIFSHGMQPYYGMGHEEVIYYVRDGHILSCPENC 967
Query: 928 DDRLYNVMLRCWHQKPTARPSFTELQEIL 956
LYN+M CW +P RPSF+ + IL
Sbjct: 968 PLELYNLMRLCWSSQPPERPSFSSIHRIL 996
Score = 55.6 bits (128), Expect = 7e-06
Identities = 31/77 (40%), Positives = 42/77 (54%), Gaps = 1/77 (1%)
Query: 603 EFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELK 662
E+PR + + + +G GAFG V++A A G++ E T VAVKM+K A E
Sbjct: 688 EYPRNNIQYVRDIGEGAFGRVFQARAPGLLPMESFTMVAVKMLKEEASADMQNDFQREAA 747
Query: 663 IMVHLGKHVNIVNLLGA 679
+M H NIV LLGA
Sbjct: 748 LMAQF-DHPNIVKLLGA 763
Score = 50.4 bits (115), Expect = 3e-04
Identities = 57/221 (25%), Positives = 95/221 (42%), Gaps = 22/221 (9%)
Query: 151 QNITIRNATKKHNGVYTCLLTNTCGEEKDEFRKIFLE-KPFLSLRDLAKGKLMGNANKSI 209
Q +T+ + + +G Y C+ TN GE + L+ KP + R L+ + +
Sbjct: 59 QMLTVPHVRESDSGEYCCIATNGVGEPAKSCGALQLKMKPQIK-RHPTNLTLLVESKAVL 117
Query: 210 NIVIEIEAYPPVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVA 269
V P V +LK+D+ + +D VT L G L+I++++ D Y VA
Sbjct: 118 PCVTLGNPKPDVT---WLKDDELIKISD---RVTILDYG--ALKIHNVRKEDAGQYRCVA 169
Query: 270 ENKY---LTKNYTVDLRVFTKPEAKLLNNRIIKRLENSEMNFACKVTGYPLPDVTWIFSN 326
N + ++K T++++V P L + K ++ C TG P+P +TW+
Sbjct: 170 RNSFGLSISKPVTIEVQV---PARILQVPKESKVAYGGLVSLQCNATGNPVPTITWL--- 223
Query: 327 DEEHELSSTKSEQESLYAKT--DYLKISVQASGVITCNAHN 365
E S S E+L LK+ V + TC A N
Sbjct: 224 -ENGNTISGASVDEALSGDVIQSVLKVRVSKPALYTCLASN 263
Score = 40.3 bits (90), Expect = 0.30
Identities = 24/71 (33%), Positives = 40/71 (56%), Gaps = 9/71 (12%)
Query: 447 MEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKD 506
+E +++ L C G P+P + W KDDELI + V I+++ +I N++++D
Sbjct: 111 VESKAV-LPCVTLGNPKPDVTWLKDDELIKISDR----VTILDY----GALKIHNVRKED 161
Query: 507 NGIYECVALNN 517
G Y CVA N+
Sbjct: 162 AGQYRCVARNS 172
>UniRef50_Q60WJ5 Cluster: Putative uncharacterized protein CBG19102;
n=1; Caenorhabditis briggsae|Rep: Putative
uncharacterized protein CBG19102 - Caenorhabditis
briggsae
Length = 943
Score = 146 bits (354), Expect = 3e-33
Identities = 72/163 (44%), Positives = 102/163 (62%), Gaps = 4/163 (2%)
Query: 803 LGWAFQIARGMEYLANRKVLHGDLAARNVLLADD---NVVKICDFGLARSMYNNEEYQKK 859
L +A+QI +GM +L ++K++H DLAARNVL+ + K+ DFGLA S +E +
Sbjct: 686 LNFAWQITQGMRFLVDKKIIHRDLAARNVLITEQCGMKSAKVSDFGLAISCEPSENGNEV 745
Query: 860 ENSP-LPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDG 918
S LP+KWLA+E + FS +SDVWS+GIV++EM+SL + P+ I PT+L+ L G
Sbjct: 746 TGSDRLPIKWLALESLEKAEFSHKSDVWSFGIVIFEMYSLGEVPFAEIEPTELIAHLKTG 805
Query: 919 NRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
R + P A D++ +M CW +KP RP F EL IL LE
Sbjct: 806 ARPKTPLLATDKIEEIMASCWEEKPLKRPEFDELSSILATQLE 848
Score = 46.0 bits (104), Expect = 0.006
Identities = 37/120 (30%), Positives = 64/120 (53%), Gaps = 15/120 (12%)
Query: 602 FEFPREKLTF-GKQLGAGAFGVVYKAEARGI---INAEVTTPV--------AVKMVKRTA 649
+E EKL ++LG GA+G V+K + GI IN +T AVKM+ + A
Sbjct: 550 WELSWEKLVVKNEKLGHGAYGHVFKGKINGIPPAINKFLTAEALDFTDCDCAVKMLPKYA 609
Query: 650 DNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ E+++M +LG + +IVN+LG T I+ + +V+ EYC + ++ Y++ +
Sbjct: 610 TESAKQEFRHEIELMKNLGFNEHIVNMLGCIT--ISTKSCLVL-EYCCHRDLLRYVKNKK 666
>UniRef50_Q170Z1 Cluster: Tyrosine-protein kinase receptor; n=1; Aedes
aegypti|Rep: Tyrosine-protein kinase receptor - Aedes
aegypti (Yellowfever mosquito)
Length = 2073
Score = 146 bits (354), Expect = 3e-33
Identities = 65/160 (40%), Positives = 100/160 (62%), Gaps = 4/160 (2%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLAD----DNVVKICDFGLARS 849
P LT L+ +A G YL +H DLA RN L++ + VVKI DFGLAR
Sbjct: 1913 PSMLTLLDLISMCVDVATGCRYLEEMHFVHRDLACRNCLVSSMDPRERVVKIGDFGLARD 1972
Query: 850 MYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPT 909
+Y N+ Y+K+ LPV+W++ E +VD +F++QSD+W++G++LWE+ +L + PYP +
Sbjct: 1973 IYKNDYYRKEGEGLLPVRWMSPESLVDGVFTSQSDIWAFGVLLWEIMTLGQQPYPARNNV 2032
Query: 910 DLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSF 949
++L ++ DG RL +P + LY +ML+CW P RP+F
Sbjct: 2033 EVLHYVRDGGRLTRPQDCPEELYQLMLKCWSYSPEDRPTF 2072
Score = 55.6 bits (128), Expect = 7e-06
Identities = 41/150 (27%), Positives = 74/150 (49%), Gaps = 10/150 (6%)
Query: 560 KLKKQRELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGA 619
+L REL + G NF N ++ + D + LLP + + +T LG+GA
Sbjct: 1768 ELANLRELPRRG--NFIHSNNILYSSSPLTDSEIALLPQIRREQI---SMTSSPFLGSGA 1822
Query: 620 FGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGA 679
FG VY+ +G + E T VA+K +++ A E +M + KH +I+ L+G
Sbjct: 1823 FGEVYEGIVKG-VGGEAETRVAIKTLRKGATEQEKAEFLQEAHLMSNF-KHKHILKLIGV 1880
Query: 680 CTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
C + L +++E + G++ +Y++ +R
Sbjct: 1881 C---LDLDSLYIVMELMQGGDLLSYLRSNR 1907
>UniRef50_UPI00015B6133 Cluster: PREDICTED: similar to protein
tyrosine kinase; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to protein tyrosine kinase - Nasonia
vitripennis
Length = 739
Score = 146 bits (353), Expect = 4e-33
Identities = 69/154 (44%), Positives = 94/154 (61%)
Query: 805 WAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPL 864
WA QIA GM+YL +++H DLAARN+LLA + KI DFGL+R+ +N+ Y+
Sbjct: 569 WASQIACGMKYLEEIRLVHRDLAARNILLASKHQAKISDFGLSRTFGSNDYYKATAGGKW 628
Query: 865 PVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKP 924
P+KW A E FS SDVWSYGI LWEMFS + PY + T+++ + G+RL +P
Sbjct: 629 PIKWYAPESYNYGTFSHASDVWSYGITLWEMFSYGEQPYGDRRGTEVIDLVEKGDRLAQP 688
Query: 925 PFADDRLYNVMLRCWHQKPTARPSFTELQEILGN 958
D +Y VM +CW P RP+F EL +I +
Sbjct: 689 EQCPDHVYKVMQKCWSYSPADRPTFQELLDIFSS 722
Score = 39.5 bits (88), Expect = 0.52
Identities = 28/92 (30%), Positives = 47/92 (51%), Gaps = 8/92 (8%)
Query: 589 IDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTT--PVAVKMVK 646
I+ + +P + F P E + G+ LG G FG VY+ G+ ++ T PVA+KM++
Sbjct: 445 IENDNETVPLTQVF-VPGENIILGEVLGEGEFGAVYE----GLFDSPSGTQEPVAIKMLR 499
Query: 647 RTADNMYIKALASELKIMVHLGKHVNIVNLLG 678
T + + E ++M+ H IV L+G
Sbjct: 500 DTHNIATREEFLREARLMMTFNHHC-IVKLIG 530
>UniRef50_Q9XVQ7 Cluster: Putative uncharacterized protein; n=2;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 442
Score = 146 bits (353), Expect = 4e-33
Identities = 72/173 (41%), Positives = 106/173 (61%), Gaps = 4/173 (2%)
Query: 795 RPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNE 854
R L LL +A Q+A+GM YLA + +H DLAARN +++ D +VK+ DFGLA + + E
Sbjct: 234 RALCVLELLDFAHQVAQGMSYLAAQHFVHRDLAARNCMISADRIVKVADFGLAVDLLDKE 293
Query: 855 EY-QKKENSP--LPVKWLAIECMVDR-IFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTD 910
Y + E P LP+KWLA E + DR +FS+ +DVWS+G+++WE+ + A +PY +S T
Sbjct: 294 SYIDESETGPARLPLKWLAPESLRDRRVFSSATDVWSFGVLMWELLTRAASPYGEVSNTK 353
Query: 911 LLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
+ +L G RL +P D +Y++M CW P RP F L L L++N
Sbjct: 354 VRHYLETGMRLPQPTHCPDIIYDLMQCCWRSTPEDRPDFVFLSHRLRALLQEN 406
Score = 38.7 bits (86), Expect = 0.91
Identities = 35/121 (28%), Positives = 57/121 (47%), Gaps = 8/121 (6%)
Query: 605 PREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVK--RTADNMYIKALASELK 662
P E + +G G FG VY+ R A PVAVK +K R D +I+ E
Sbjct: 132 PSEAVVLETIVGKGYFGNVYRGRMRD--PAGRLIPVAVKTLKGERARDIAHIEKFLREGV 189
Query: 663 IMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYM-QKHREVFIDQLTDNAE 721
+M HL H ++++LLG V++ Y + G++ Y+ +R + + +L D A
Sbjct: 190 VMKHL-DHPHVLSLLGISISPAGNP--WVVLPYMEGGDLKTYIADPNRALCVLELLDFAH 246
Query: 722 K 722
+
Sbjct: 247 Q 247
>UniRef50_Q008W6 Cluster: Gamma-carboxyglutamic acid protein 1; n=2;
Ascidiacea|Rep: Gamma-carboxyglutamic acid protein 1 -
Ciona intestinalis (Transparent sea squirt)
Length = 556
Score = 146 bits (353), Expect = 4e-33
Identities = 67/170 (39%), Positives = 101/170 (59%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
LT LL + +A GMEYLA +K +H DLAARN ++ + VK+ DFGL+R +++ + Y
Sbjct: 275 LTVLKLLKFCKDVAMGMEYLAEKKFVHRDLAARNCMVDKNWCVKVADFGLSRDLFDRDYY 334
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
+ + LP+KW+ E + + +SDVWSYGIV WE+ + PYP + +L++LS
Sbjct: 335 RSSVKTQLPLKWMPPESIKYGRYGEKSDVWSYGIVCWEIMTRGAIPYPTVQAVAILQYLS 394
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERN 966
+GNR+E+P +LY M +CW RP+F EL I + D R+
Sbjct: 395 EGNRMERPECCPHKLYKTMEKCWLDDTERRPTFEELVTITTKIVRDARRS 444
Score = 38.3 bits (85), Expect = 1.2
Identities = 27/109 (24%), Positives = 54/109 (49%), Gaps = 6/109 (5%)
Query: 606 REKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMV 665
RE+L G+ + +G FG VY+ + R N VAVK +K ++ ++ E +M+
Sbjct: 169 RERLQLGEVITSGNFGDVYRGKLRSRQN--TWHDVAVKSLKSLENHEDVEKFLRE-GVMM 225
Query: 666 HLGKHVNIVNLLGACTKHIAKR---ELIVIVEYCKYGNIHNYMQKHREV 711
H N++ L+G C +R ++I+ + + G++ +++ V
Sbjct: 226 RGLDHRNVLALIGVCVDGEVERLQTSPLIILPFMENGDLRTFLRDGNNV 274
>UniRef50_P04626 Cluster: Receptor tyrosine-protein kinase erbB-2
precursor; n=36; Euteleostomi|Rep: Receptor
tyrosine-protein kinase erbB-2 precursor - Homo sapiens
(Human)
Length = 1255
Score = 146 bits (353), Expect = 4e-33
Identities = 69/169 (40%), Positives = 97/169 (57%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
L S LL W QIA+GM YL + +++H DLAARNVL+ N VKI DFGLAR + +E
Sbjct: 817 LGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETE 876
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
+ +P+KW+A+E ++ R F+ QSDVWSYG+ +WE+ + PY I ++ L
Sbjct: 877 YHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLE 936
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNER 965
G RL +PP +Y +M++CW RP F EL D +R
Sbjct: 937 KGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQR 985
Score = 37.9 bits (84), Expect = 1.6
Identities = 28/98 (28%), Positives = 49/98 (50%), Gaps = 8/98 (8%)
Query: 613 KQLGAGAFGVVYKAEARGIINAE-VTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHV 671
K LG+GAFG VYK I + E V PVA+K+++ K + E +M +G
Sbjct: 724 KVLGSGAFGTVYK--GIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPY 781
Query: 672 NIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ LLG C + ++ + YG + ++++++R
Sbjct: 782 -VSRLLGICLTSTVQ----LVTQLMPYGCLLDHVRENR 814
>UniRef50_Q7KJ08 Cluster: Receptor protein tyrosine kinase ALK splice
variant A; n=9; Diptera|Rep: Receptor protein tyrosine
kinase ALK splice variant A - Drosophila melanogaster
(Fruit fly)
Length = 1701
Score = 145 bits (352), Expect = 5e-33
Identities = 80/240 (33%), Positives = 126/240 (52%), Gaps = 9/240 (3%)
Query: 793 QPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDN---VVKICDFGLARS 849
+P LT LL A +A+G Y+ +++ +H D+AARN LL+ VVKI DFG++R
Sbjct: 1294 RPSLLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRD 1353
Query: 850 MYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPT 909
+Y ++ Y+K + LP+KW+ E +D IF++++DVWS+GI+LWE+FSL ++PYP T
Sbjct: 1354 IYRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNT 1413
Query: 910 DLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYV 969
++ + G RL P +Y VM CW+ P RP+F L E L +D
Sbjct: 1414 QVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLEHLTACTQDAS----- 1468
Query: 970 DLNAPYNEMNAELMTGEDYLAMVCAPDYNNIVTPSPNYVNMAKSFFPATPTPKDQEGYLP 1029
+NAP + + D ++ P+ P+Y+ P+ GY+P
Sbjct: 1469 IMNAPLPNILGPTASERDD-TVIRPPNGEEFCLAVPDYLVPLPPGGSNNPSMASGSGYVP 1527
Score = 50.8 bits (116), Expect = 2e-04
Identities = 37/137 (27%), Positives = 61/137 (44%), Gaps = 5/137 (3%)
Query: 574 NFKSGNKKSFNPNLGIDEQAD-LLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGII 632
N N +FNPN G D + + + + R+ L LG GAFG VY A R
Sbjct: 1157 NIDDSNLNNFNPNYGCDGILNGHIDVNSLPQVARDSLQLVNALGKGAFGEVYMALYRHRD 1216
Query: 633 NAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVI 692
V VAVK ++ + E IM H N+V+L+G C ++ ++
Sbjct: 1217 GDAVEMGVAVKTLREDPKREKEEDFLKEAAIMAKF-NHPNMVHLIGVC---FDRQPYYIV 1272
Query: 693 VEYCKYGNIHNYMQKHR 709
+E G++ +++++R
Sbjct: 1273 LELLAGGDLQKFLRENR 1289
>UniRef50_P00522 Cluster: Tyrosine-protein kinase Abl; n=5;
Eumetazoa|Rep: Tyrosine-protein kinase Abl - Drosophila
melanogaster (Fruit fly)
Length = 1620
Score = 145 bits (352), Expect = 5e-33
Identities = 70/179 (39%), Positives = 104/179 (58%), Gaps = 1/179 (0%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
LL A QIA GM YL +R +H DLAARN L+ D+ +VK+ DFGLAR M ++ Y
Sbjct: 469 LLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLM-RDDTYTAHAG 527
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
+ P+KW A E + FST+SDVW++G++LWE+ + +PYP I TD+ L G R+
Sbjct: 528 AKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRM 587
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLNAPYNEMNA 980
E+PP +Y++M +CW T RP+F + L + +++ V+ N +A
Sbjct: 588 ERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMFQESSITEAVEKQLNANATSA 646
Score = 52.0 bits (119), Expect = 9e-05
Identities = 35/112 (31%), Positives = 58/112 (51%), Gaps = 11/112 (9%)
Query: 595 LLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYI 654
L P +++E R + +LG G +G VY+A + N VAVK +K D M +
Sbjct: 357 LSPEPDEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNT-----VAVKTLKE--DTMAL 409
Query: 655 KALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
K E IM + KH N+V L+G CT+ + +I E+ +GN+ ++++
Sbjct: 410 KDFLEEAAIMKEM-KHPNLVQLIGVCTR---EPPFYIITEFMSHGNLLDFLR 457
>UniRef50_UPI00015B4B0F Cluster: PREDICTED: similar to
proto-oncogene tyrosine-protein kinase abl1; n=1;
Nasonia vitripennis|Rep: PREDICTED: similar to
proto-oncogene tyrosine-protein kinase abl1 - Nasonia
vitripennis
Length = 1522
Score = 145 bits (351), Expect = 7e-33
Identities = 67/169 (39%), Positives = 101/169 (59%), Gaps = 1/169 (0%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ A QIA GM YL +R +H DLAARN L+ + ++VK+ DFGLAR M ++ Y
Sbjct: 388 LMHMATQIASGMSYLESRNFIHRDLAARNCLVGESHLVKVADFGLARLM-RDDTYTAHAG 446
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
+ P+KW A E + FST+SDVW++GI+LWE+ + +PYP + TD+ L G R+
Sbjct: 447 AKFPIKWTAPEGLAYNKFSTKSDVWAFGILLWEIATYGMSPYPGVDLTDVYHMLEKGYRM 506
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVD 970
E PP ++Y +M +CW + RP+F E+ L N +++ V+
Sbjct: 507 ECPPGCPPKVYELMRQCWQWSASDRPTFKEIHHSLENMFQESSITEEVE 555
Score = 51.6 bits (118), Expect = 1e-04
Identities = 35/112 (31%), Positives = 56/112 (50%), Gaps = 11/112 (9%)
Query: 595 LLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYI 654
L P +++E R + +LG G +G VY+A + VAVK +K D M +
Sbjct: 276 LSPEPDEWEINRTDIVMRHKLGGGQYGDVYEA-----VWKRYNMTVAVKTLKE--DTMAL 328
Query: 655 KALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
K E IM + KH N+V L+G CT+ + +I E+ GN+ +Y++
Sbjct: 329 KDFLEEAAIMKEM-KHRNLVQLIGVCTR---EPPFYIITEFMSKGNLLDYLR 376
>UniRef50_UPI0000519AF4 Cluster: PREDICTED: similar to Abl tyrosine
kinase CG4032-PA; n=1; Apis mellifera|Rep: PREDICTED:
similar to Abl tyrosine kinase CG4032-PA - Apis
mellifera
Length = 1439
Score = 145 bits (351), Expect = 7e-33
Identities = 67/169 (39%), Positives = 101/169 (59%), Gaps = 1/169 (0%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ A QIA GM YL +R +H DLAARN L+ ++++VK+ DFGLAR M ++ Y
Sbjct: 387 LMHMATQIASGMSYLESRNFIHRDLAARNCLVGENHLVKVADFGLARLM-RDDTYTAHAG 445
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
+ P+KW A E + FST+SDVW++GI+LWE+ + +PYP + TD+ L G R+
Sbjct: 446 AKFPIKWTAPEGLAYNKFSTKSDVWAFGILLWEIATYGMSPYPGVDLTDVYHMLEKGYRM 505
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVD 970
E PP ++Y +M +CW RP+F E+ L N +++ V+
Sbjct: 506 ECPPGCPPKVYELMRQCWQWSAADRPTFKEIHHSLENMFQESSITEEVE 554
Score = 52.4 bits (120), Expect = 7e-05
Identities = 36/112 (32%), Positives = 56/112 (50%), Gaps = 11/112 (9%)
Query: 595 LLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYI 654
L P +++E R + +LG G +G VY+A + VAVK +K D M +
Sbjct: 275 LSPEPDEWEINRTDIVMRHKLGGGQYGDVYEA-----VWKRYNMTVAVKTLKE--DTMAL 327
Query: 655 KALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
K E IM + KH N+V LLG CT+ + +I E+ GN+ +Y++
Sbjct: 328 KDFLEEAAIMKEM-KHRNLVQLLGVCTR---EPPFYIITEFMSKGNLLDYLR 375
>UniRef50_UPI0000E471D0 Cluster: PREDICTED: similar to p80 protein,
partial; n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to p80 protein, partial -
Strongylocentrotus purpuratus
Length = 526
Score = 144 bits (349), Expect = 1e-32
Identities = 66/173 (38%), Positives = 104/173 (60%), Gaps = 3/173 (1%)
Query: 793 QPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLA---DDNVVKICDFGLARS 849
+P +T LL +A+G YL +R+ +H D+AARN+LL KI DFG+AR
Sbjct: 47 KPSSITMKDLLQITQDVAQGCRYLESRRFIHRDIAARNILLTTKESGRAAKIADFGMARD 106
Query: 850 MYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPT 909
+Y + Y+K + LPVKW+ E D IF++++DVW+YG++LWE+ SL PYP +S
Sbjct: 107 IYRADYYRKGGQALLPVKWMPPEAFQDGIFTSKTDVWAYGVLLWEIISLGFMPYPGMSNQ 166
Query: 910 DLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLED 962
++++++S G R+ P ++N+M +CW P RP FT + E + L+D
Sbjct: 167 EVIQFVSAGERMNPPRSCPQPVFNLMSQCWRHIPEDRPPFTTILESINYCLQD 219
>UniRef50_UPI00015B55E4 Cluster: PREDICTED: similar to receptor-like
tyrosine kinase; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to receptor-like tyrosine kinase -
Nasonia vitripennis
Length = 503
Score = 143 bits (347), Expect = 2e-32
Identities = 64/154 (41%), Positives = 99/154 (64%)
Query: 806 AFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLP 865
A Q A+G++YL ++++H DLAARN ++ D+ V+I D LAR ++ + Y +N P
Sbjct: 342 ALQAAKGVQYLHRKRLVHRDLAARNCVVDDELRVQITDNALARDLFPQDYYCLGDNENRP 401
Query: 866 VKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPP 925
+KWLAIE ++ + FST SDVW++G++LWE+ +LA+ PY + P ++ +L DG RL +P
Sbjct: 402 IKWLAIESLLSKSFSTASDVWAFGVLLWELTTLAQQPYVEVDPFEMASYLRDGYRLAQPV 461
Query: 926 FADDRLYNVMLRCWHQKPTARPSFTELQEILGNF 959
D L+ VM CW P RP+F++L L F
Sbjct: 462 NCPDELFAVMAYCWAMSPDERPTFSQLIVCLQEF 495
>UniRef50_UPI0000D57699 Cluster: PREDICTED: similar to CG18247-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG18247-PA - Tribolium castaneum
Length = 725
Score = 143 bits (347), Expect = 2e-32
Identities = 66/158 (41%), Positives = 94/158 (59%), Gaps = 1/158 (0%)
Query: 805 WAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKK-ENSP 863
WA QIA GM YL ++ +H DLAARN+LLA + KI DFGL+R++ + EY + +
Sbjct: 554 WAAQIACGMNYLEEQRFIHRDLAARNILLASQHQAKISDFGLSRALAADHEYYRALQGGK 613
Query: 864 LPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEK 923
P+KW A E FS +SDVWS+G+ +WEM+S PY + +D ++ + DG RL++
Sbjct: 614 WPLKWYAPESYNYGQFSHKSDVWSFGVAIWEMYSFGDVPYGELKGSDAIKIIEDGERLKQ 673
Query: 924 PPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
P D +Y +M RCW RP+F EL E + E
Sbjct: 674 PDACPDHIYEIMRRCWEYDAENRPTFKELLEFFSSDTE 711
Score = 38.7 bits (86), Expect = 0.91
Identities = 30/106 (28%), Positives = 50/106 (47%), Gaps = 8/106 (7%)
Query: 605 PREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIM 664
P E+L G+ +G G FG VY+ E+ VA+K V+ A+ E +M
Sbjct: 446 PLERLKMGRVIGEGEFGSVYEGTYTKRNGEEI--KVAIKTVRHEQIET-SNAILKEAHVM 502
Query: 665 VHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHRE 710
+ L H +V L+G R L+++ E G++ NY+ ++E
Sbjct: 503 MRLNHHC-VVKLIGLS----KGRPLLMVQELVALGSMLNYIILNKE 543
>UniRef50_UPI000065FEDC Cluster: Activated CDC42 kinase 1 (EC
2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein
2).; n=3; Deuterostomia|Rep: Activated CDC42 kinase 1
(EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor
protein 2). - Takifugu rubripes
Length = 1127
Score = 143 bits (347), Expect = 2e-32
Identities = 70/167 (41%), Positives = 101/167 (60%), Gaps = 2/167 (1%)
Query: 792 HQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMY 851
H P+ L +A Q++ GM YL R+ +H DLAARN+LLA + +KI DFGL R++
Sbjct: 233 HPQGPVLIHTLCQYAVQVSCGMAYLEQRRFIHRDLAARNILLASAHKIKIGDFGLMRALP 292
Query: 852 NN-EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTD 910
NN E Y +E+ +P W A E + R FS +D W +G+ LWEMF+ + P+ ++ +
Sbjct: 293 NNHEHYVMQEHRKVPFAWCAPESLKTRTFSHATDTWMFGVTLWEMFTHGQEPWLGLNGSQ 352
Query: 911 LLRWL-SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEIL 956
+L + +G RL KP +YNVML+CW QKP RP+F L+E L
Sbjct: 353 ILHKIDKEGERLPKPEDCPQDIYNVMLQCWAQKPDDRPTFVALREFL 399
>UniRef50_Q9Y1Y2 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 743
Score = 143 bits (347), Expect = 2e-32
Identities = 76/171 (44%), Positives = 102/171 (59%), Gaps = 3/171 (1%)
Query: 786 DYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFG 845
DY+YE QP P L WA +IA GM YL ++ +H DLAARN+L+ VKI DFG
Sbjct: 552 DYLYERKQPIPDVLTLKL-WAAEIASGMMYLETKRFVHRDLAARNILVQSMKQVKISDFG 610
Query: 846 LARSMYNNEEYQK-KENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYP 904
L+R++ N +Y K + PVKW A E + FS SDVWSYGI LWEMFS PY
Sbjct: 611 LSRAVGANSDYYKASQGGRWPVKWYAPESINFGTFSHASDVWSYGITLWEMFSFGDAPYG 670
Query: 905 NISPTDLLRWLSDGN-RLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQE 954
+++ ++L + + N RLE P +Y +MLRCW +P RP+F +L +
Sbjct: 671 DMTGAEVLDRVENLNYRLECPRDCPSSIYELMLRCWSLEPNERPTFAQLYD 721
Score = 38.7 bits (86), Expect = 0.91
Identities = 32/109 (29%), Positives = 51/109 (46%), Gaps = 7/109 (6%)
Query: 609 LTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLG 668
L G +LG G FG V K +G ++ VAVK ++ + K A E IMV L
Sbjct: 465 LHLGAELGQGEFGSVLKGLYKGADGKKI--EVAVKTLRLDSQGHGEKEFAREAGIMVTL- 521
Query: 669 KHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLT 717
H IV L+G + ++++ E G + +Y+ + ++ D LT
Sbjct: 522 NHPCIVKLIGITN----GKPMMMVQELISMGALVDYLYERKQPIPDVLT 566
>UniRef50_Q70W09 Cluster: Receptor tyrosine kinase VIII; n=1; Ciona
intestinalis|Rep: Receptor tyrosine kinase VIII - Ciona
intestinalis (Transparent sea squirt)
Length = 895
Score = 143 bits (347), Expect = 2e-32
Identities = 67/188 (35%), Positives = 116/188 (61%), Gaps = 6/188 (3%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
LL +A +A+GM+YL+NR +H DLAARN +L ++ V + DFGL+R++Y+ Y++
Sbjct: 666 LLLFALDVAKGMQYLSNRNFIHRDLAARNCMLDENYKVVVSDFGLSRTVYSESYYRQTHI 725
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
S +PVKW+A+E + D IF+ SDVWS+G+ +WE+ ++ ++PYP + ++ + L +G RL
Sbjct: 726 SKMPVKWMALESLADNIFTPLSDVWSFGVTVWEILTMGQSPYPGVGNHEVYQLLRNGTRL 785
Query: 922 EKPPFADDRL-YNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLNAPYNEMNA 980
KP ++ ++V+ CW + R +F +L E+L N D+ P + +A
Sbjct: 786 NKPEHCPSKVWFSVVFPCWTVQVKDRITFDKLVEVLSEI----TCNPTEDIETPIVQ-SA 840
Query: 981 ELMTGEDY 988
++G +Y
Sbjct: 841 SCLSGSEY 848
Score = 36.3 bits (80), Expect = 4.9
Identities = 41/132 (31%), Positives = 59/132 (44%), Gaps = 15/132 (11%)
Query: 586 NLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIIN--------AEVT 637
++ I +Q + L D E R KL GK LG G FG VYKA N A V
Sbjct: 521 SISIVQQLEELVQDVLIENKRLKL--GKILGEGEFGFVYKATISADANSNNNSNQTATVQ 578
Query: 638 TPVAVKMVKRTADN-MYIKALASELKIMVHLGKHVNIVNLLG-ACTKHIAKREL--IVIV 693
VAVK +K T ++ E M L H N++ L+G A T + +V++
Sbjct: 579 GHVAVKSIKVTGHTYTEVEGFVKEGLRMKDL-DHPNVMALIGIAFTAEDLNKPASPLVVL 637
Query: 694 EYCKYGNIHNYM 705
Y G++ +Y+
Sbjct: 638 PYMPNGDLRSYL 649
>UniRef50_O77440 Cluster: Protein-tyrosine kinase HTK98; n=1; Hydra
vulgaris|Rep: Protein-tyrosine kinase HTK98 - Hydra
attenuata (Hydra) (Hydra vulgaris)
Length = 624
Score = 143 bits (347), Expect = 2e-32
Identities = 69/159 (43%), Positives = 95/159 (59%), Gaps = 2/159 (1%)
Query: 808 QIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSM-YNNEEYQKKENSPLPV 866
Q+ GM YL ++ +H DLAARNVL+ +N VKI DFG++R+M NE Y+ + P+
Sbjct: 463 QVDEGMNYLESQHFVHRDLAARNVLVVSENFVKISDFGMSRAMGVGNEYYRAERAGKWPL 522
Query: 867 KWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPF 926
KW A EC+ FS++ DVWSYGI +WE S PY + ++ L G RL KP
Sbjct: 523 KWYAPECIYYHKFSSKGDVWSYGITMWEAVSYGGKPYQGMRGPVIVEKLESGYRLPKPDN 582
Query: 927 ADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNER 965
D +Y +ML+CW P RPSF E+ IL +++ NER
Sbjct: 583 CSDAVYTLMLKCWETNPDDRPSFMEIGIILAQYIQ-NER 620
>UniRef50_Q19238 Cluster: Putative tyrosine-protein kinase F09A5.2;
n=2; Caenorhabditis|Rep: Putative tyrosine-protein
kinase F09A5.2 - Caenorhabditis elegans
Length = 894
Score = 143 bits (347), Expect = 2e-32
Identities = 70/173 (40%), Positives = 107/173 (61%), Gaps = 3/173 (1%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ A+Q+A GM YLA++ +H DLAARN+LL K+ DFGL R M ++ Y K
Sbjct: 630 LVSIAWQVADGMSYLASKNFIHRDLAARNILLTKSLTAKVSDFGLCRYM-DSALYTAK-G 687
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
LP+KW+++E + FST++DVWS+G++L+E+FS+ PYP I D+L L G RL
Sbjct: 688 GRLPIKWMSVEALKLYEFSTKTDVWSFGVLLFEIFSMGDVPYPTIQQVDMLEHLLAGGRL 747
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQ-EILGNFLEDNERNRYVDLNA 973
+P + ++N+M +CW +KP RP F E++ EI D+E Y+ + +
Sbjct: 748 SQPLKCPNEIFNIMQKCWAEKPEDRPEFNEMRGEITVMLNLDDESYGYLSVES 800
Score = 43.6 bits (98), Expect = 0.032
Identities = 30/111 (27%), Positives = 54/111 (48%), Gaps = 18/111 (16%)
Query: 615 LGAGAFGVVYKAEARG-----IINAEVTTPV----------AVKMVKRTADNMYIKALAS 659
LG GAF VYK +G ++N + V A+K + AD
Sbjct: 470 LGNGAFANVYKGIVKGKIPLLVVNNSLNMTVESENNGHYEAAIKKLPAHADEQNHLDFFH 529
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHRE 710
E+ M LG H +++++LG C + E +++VEYC G++ ++++H++
Sbjct: 530 EIDFMKRLGHHPHVISMLG-CVSN--PYEPLIVVEYCARGDLLKFLRRHKD 577
>UniRef50_Q9BKL8 Cluster: Tyrosine-protein kinase receptor; n=2;
Eumetazoa|Rep: Tyrosine-protein kinase receptor -
Aplysia californica (California sea hare)
Length = 1145
Score = 143 bits (346), Expect = 3e-32
Identities = 65/156 (41%), Positives = 97/156 (62%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
L +L + Q+A GMEYLA+ +H DLAARN+L+AD VKI DFGL+R +Y+++ Y
Sbjct: 687 LEYSEMLHVSTQVAAGMEYLASHHFVHRDLAARNILVADGLTVKISDFGLSRDVYSSDYY 746
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
+ + S LPV+W+ E ++ F+T SDVW++G+VLWE+FS PY S +++ +
Sbjct: 747 RVQSKSLLPVRWMPPEAILYGKFTTDSDVWAFGVVLWEVFSYGLQPYYGFSNQEVIEMIR 806
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTEL 952
L P R+Y +M+ CWH+ P RP F E+
Sbjct: 807 SRQILGCPEECPARIYGLMVECWHEMPARRPPFREI 842
Score = 72.5 bits (170), Expect = 6e-11
Identities = 45/138 (32%), Positives = 68/138 (49%), Gaps = 9/138 (6%)
Query: 576 KSGNKKSFNPNLGIDEQADLLPYDEKF-----EFPREKLTFGKQLGAGAFGVVYKAEARG 630
KS N ++ PN + ++ P + K EFP + F ++LG GAFG VYK E G
Sbjct: 533 KSHNTRASRPNNKQAQPVEMSPLNPKSASRAREFPMPNIRFLQELGEGAFGKVYKGELVG 592
Query: 631 IINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELI 690
+ T VA+K +K A E+ +M + +H NIV LLG C K + +
Sbjct: 593 LYGESSVTTVAIKTLKENALPKVQNDFRREVDLMSDM-RHPNIVCLLGVCMK---QEPMC 648
Query: 691 VIVEYCKYGNIHNYMQKH 708
++ EY G++H Y+ H
Sbjct: 649 MLFEYMAQGDLHEYLLSH 666
Score = 46.0 bits (104), Expect = 0.006
Identities = 22/76 (28%), Positives = 39/76 (51%), Gaps = 2/76 (2%)
Query: 442 KDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIEN 501
K+ G+++++ CE G P P WYKDD +I+N+ + T S +I +
Sbjct: 91 KNVTKYRGQAVRIRCEITGNPIPNYSWYKDDVIINNDPSDRRMGH--KPTAWGSRLKIND 148
Query: 502 MQEKDNGIYECVALNN 517
++ D+ +Y C A N+
Sbjct: 149 VRPSDSAVYTCKAEND 164
>UniRef50_Q2LC18 Cluster: Tyrosine-protein kinase receptor; n=2;
Strongylocentrotus purpuratus|Rep: Tyrosine-protein
kinase receptor - Strongylocentrotus purpuratus (Purple
sea urchin)
Length = 1072
Score = 143 bits (346), Expect = 3e-32
Identities = 74/207 (35%), Positives = 110/207 (53%), Gaps = 2/207 (0%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P T LL A +IA GM +LA RK +H DL+ARN L++ + K+ DFGLAR +Y +
Sbjct: 804 PSVPTLEQLLNMAAEIADGMSFLAARKYVHRDLSARNCLVSGEGTCKVADFGLARDIYQS 863
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
+ Y+K+ LP++W+A E + D +F SDVWS+GI+LWEM +L + PY +S +
Sbjct: 864 DYYRKERGGMLPIRWMAPESVKDGVFQASSDVWSFGILLWEMATLGELPYQGLSNEEAGE 923
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNF--LEDNERNRYVDL 971
++ GN L P +++ +M+ CW + RP F E+ L ++ L D+ L
Sbjct: 924 YIKGGNVLRPPENCPEKMQEIMMACWQYQEKLRPLFGEIILNLQDYGLLRDSFAQNCFFL 983
Query: 972 NAPYNEMNAELMTGEDYLAMVCAPDYN 998
N N A L V D N
Sbjct: 984 NEQLNASAAPADMSSKELETVSILDQN 1010
Score = 63.3 bits (147), Expect = 4e-08
Identities = 40/118 (33%), Positives = 67/118 (56%), Gaps = 6/118 (5%)
Query: 593 ADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGII-NAEVTTPVAVKMVKRTADN 651
+D+ DE +EFPR+KL ++LG G+FG+VY+ A+GI+ E + VA+K V+ A
Sbjct: 684 SDMYVADE-WEFPRDKLEIIRELGKGSFGMVYEGLAKGILPEEEEISRVAIKSVQANASM 742
Query: 652 MYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+E +M + H N+V LLG +K + VI+E+ G++ N+++ R
Sbjct: 743 RDRIEFLNEASVMKLIDAH-NVVRLLGVVSK---GQPTYVIMEFMAQGDLKNWLRARR 796
>UniRef50_A7SZN9 Cluster: Predicted protein; n=3; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 283
Score = 143 bits (346), Expect = 3e-32
Identities = 63/147 (42%), Positives = 90/147 (61%)
Query: 806 AFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLP 865
A +A GM +L + +H DLAARNVLL + K+ DFGL+R +Y N Y+K LP
Sbjct: 126 AADVASGMAHLEKMRCVHRDLAARNVLLDEALTAKVSDFGLSRDIYTNSVYEKTTGGKLP 185
Query: 866 VKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPP 925
KW+AIE + ++++ SD WS+G++LWE+ + PYP + ++L L G RLEKPP
Sbjct: 186 AKWMAIESIEAGLYTSHSDAWSFGVLLWEIETGGCIPYPTFTVQEMLNSLKKGYRLEKPP 245
Query: 926 FADDRLYNVMLRCWHQKPTARPSFTEL 952
+ + LY +ML CW P RP F E+
Sbjct: 246 YCLEPLYTLMLSCWSADPALRPHFVEI 272
Score = 80.2 bits (189), Expect = 3e-13
Identities = 46/106 (43%), Positives = 63/106 (59%), Gaps = 4/106 (3%)
Query: 603 EFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELK 662
+ PRE + G+ LG G FG V + V AVK +KRTA K L +EL
Sbjct: 1 QIPREAVELGRTLGEGEFGKVIEGNVTEPDGTRVHC--AVKKLKRTATESDWKDLLNELD 58
Query: 663 IMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKH 708
IMV +G+H NIVNL+GAC+ + L+VIVE+C GN+ +Y+QK+
Sbjct: 59 IMVQVGEHPNIVNLIGACSD--PEGPLMVIVEFCGNGNLLHYLQKN 102
>UniRef50_P00529 Cluster: Tyrosine-protein kinase transforming
protein ros; n=3; root|Rep: Tyrosine-protein kinase
transforming protein ros - Avian sarcoma virus (strain
UR2)
Length = 402
Score = 143 bits (346), Expect = 3e-32
Identities = 68/166 (40%), Positives = 100/166 (60%), Gaps = 6/166 (3%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLAD------DNVVKICDFGLARSM 850
LT LL I +G YL + +H DLAARN L+++ VVKI DFGLAR +
Sbjct: 204 LTLTDLLDICLDICKGCVYLEKMRFIHRDLAARNCLVSEKQYGSCSRVVKIGDFGLARDI 263
Query: 851 YNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTD 910
Y N+ Y+K+ LPV+W+A E ++D +F+ SDVW++G+++WE +L + PYP +S +
Sbjct: 264 YKNDYYRKRGEGLLPVRWMAPESLIDGVFTNHSDVWAFGVLVWETLTLGQQPYPGLSNIE 323
Query: 911 LLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEIL 956
+L + G RLE P D + ++M RCW Q P RP+F +Q L
Sbjct: 324 VLHHVRSGGRLESPNNCPDDIRDLMTRCWAQDPHNRPTFFYIQHKL 369
Score = 54.0 bits (124), Expect = 2e-05
Identities = 36/108 (33%), Positives = 57/108 (52%), Gaps = 5/108 (4%)
Query: 604 FPREKLTFGKQLGAGAFGVVYKAEARGII-NAEVTTPVAVKMVKRTADNMYIKALASELK 662
FPR+KL K LG+GAFG VY+ A I+ + + VAVK +KR A + E
Sbjct: 93 FPRDKLNLHKLLGSGAFGEVYEGTALDILADGSGESRVAVKTLKRGATDQEKSEFLKEAH 152
Query: 663 IMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHRE 710
+M H +I+ LLG C + +I+E + G++ +Y++ R+
Sbjct: 153 LMSKF-DHPHILKLLGVC---LLNEPQYLILELMEGGDLLSYLRGARK 196
>UniRef50_Q91987 Cluster: BDNF/NT-3 growth factors receptor
precursor; n=17; Euteleostomi|Rep: BDNF/NT-3 growth
factors receptor precursor - Gallus gallus (Chicken)
Length = 818
Score = 143 bits (346), Expect = 3e-32
Identities = 64/169 (37%), Positives = 109/169 (64%)
Query: 790 ECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARS 849
E ++P LT +L A QIA GM YLA++ +H DLA RN L+ ++ +VKI DFG++R
Sbjct: 637 EGNRPAELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRD 696
Query: 850 MYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPT 909
+Y+ + Y+ ++ LP++W+ E ++ R F+T+SDVWS G+VLWE+F+ K P+ +S
Sbjct: 697 VYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNN 756
Query: 910 DLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGN 958
+++ ++ G L++P +Y++ML CW ++P R + E+ +L N
Sbjct: 757 EVIECITQGRVLQRPRTCPKEVYDLMLGCWQREPHMRLNIKEIHSLLQN 805
Score = 55.6 bits (128), Expect = 7e-06
Identities = 32/103 (31%), Positives = 56/103 (54%), Gaps = 5/103 (4%)
Query: 606 REKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMV 665
R + ++LG GAFG V+ AE + + VAVK +K +DN K E +++
Sbjct: 531 RHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNAR-KDFHREAELLT 589
Query: 666 HLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKH 708
+L +H +IV G C + LI++ EY K+G+++ +++ H
Sbjct: 590 NL-QHEHIVKFYGVC---VEGDPLIMVFEYMKHGDLNKFLRAH 628
Score = 43.6 bits (98), Expect = 0.032
Identities = 31/93 (33%), Positives = 43/93 (46%), Gaps = 6/93 (6%)
Query: 288 PEAKLLNNRIIKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYAKTD 347
P A L N I +E + C TG P P+V+W+ +N + S T SL K
Sbjct: 196 PSANLSNYNITV-VEGKSITLYCDTTGGPPPNVSWVLTNLVSNHESDTSKNPASLTIK-- 252
Query: 348 YLKISVQASGV-ITCNAHNSKGEYFDSSTLLVY 379
+S SG+ I+C A N GE S+ L V+
Sbjct: 253 --NVSSMDSGLWISCVAENIVGEVQTSAELTVF 283
Score = 38.7 bits (86), Expect = 0.91
Identities = 26/91 (28%), Positives = 47/91 (51%), Gaps = 10/91 (10%)
Query: 440 SNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI 499
SN + +EG+SI L+C+ G P P + W + L+SN+ D + ++ I
Sbjct: 201 SNYNITVVEGKSITLYCDTTGGPPPNVSWVLTN-LVSNHES-----DTSKNP---ASLTI 251
Query: 500 ENMQEKDNGIY-ECVALNNASELRRAYTLVL 529
+N+ D+G++ CVA N E++ + L +
Sbjct: 252 KNVSSMDSGLWISCVAENIVGEVQTSAELTV 282
Score = 36.3 bits (80), Expect = 4.9
Identities = 13/62 (20%), Positives = 32/62 (51%)
Query: 459 EGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIYECVALNNA 518
+G P+PT+ W+ + +++ + + ++N + + +++N +NG Y +A N
Sbjct: 307 KGNPKPTLQWFYEGAILNESEYICTKIHVINQSEYHGCLQLDNPTHLNNGAYTLLAKNEY 366
Query: 519 SE 520
E
Sbjct: 367 GE 368
>UniRef50_Q8WRF4 Cluster: Receptor tyrosine kinase; n=1; Monosiga
brevicollis|Rep: Receptor tyrosine kinase - Monosiga
brevicollis
Length = 1476
Score = 142 bits (345), Expect = 4e-32
Identities = 73/179 (40%), Positives = 106/179 (59%), Gaps = 6/179 (3%)
Query: 786 DYIYECH----QPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKI 841
DY+ C P+ + + + QIARGM +L + V+H DLAARNVL+ + KI
Sbjct: 816 DYLRGCRATQENPQTIRVDQMADFCLQIARGMAFLEQKNVIHRDLAARNVLVDKNFECKI 875
Query: 842 CDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKT 901
DFGLARS+ E K + LPVKW+A E + RI++T+SDVWS+G+ +WE+FSL T
Sbjct: 876 SDFGLARSIEGGE--YKTTATKLPVKWMAPESLKSRIYTTKSDVWSFGVTMWEIFSLGGT 933
Query: 902 PYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFL 960
PY D+L +L G+RL P A ++ CW + + RPSF+EL ++L + +
Sbjct: 934 PYKEHQNRDVLSFLESGHRLPSPRQAPVEFDDIARMCWVLEASDRPSFSELVDLLADIV 992
Score = 58.8 bits (136), Expect = 8e-07
Identities = 30/105 (28%), Positives = 59/105 (56%), Gaps = 4/105 (3%)
Query: 602 FEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASEL 661
+E R+ + G++LG GAFG V++A R + +V A K +K + + SE+
Sbjct: 719 WEVDRQCVRLGEELGHGAFGEVFQAWIRNSYSGKVRR-CAAKTLKPDVSFEHRQDFLSEM 777
Query: 662 KIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
+M +G H N++ ++G C + + I++VE ++GN+ +Y++
Sbjct: 778 TVMKEIGAHPNVIGIIGHCLRETPQ---ILLVELAEFGNMRDYLR 819
>UniRef50_Q86LZ8 Cluster: Insulin receptor protein kinase; n=2;
Schistosoma|Rep: Insulin receptor protein kinase -
Schistosoma mansoni (Blood fluke)
Length = 1499
Score = 142 bits (345), Expect = 4e-32
Identities = 70/160 (43%), Positives = 99/160 (61%), Gaps = 3/160 (1%)
Query: 803 LGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENS 862
+ WA Q+A GM YLA ++H DLAARN L+ VKI DFGLAR + N E Y+K +
Sbjct: 1333 INWAIQLATGMNYLAELHIIHRDLAARNCLVNSMLTVKIADFGLARLVNNQEYYRKIGQA 1392
Query: 863 PLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL- 921
LPV+W+A E + F+T+SDVWSYG+VLWE+ + A PYP +S ++++++ DG L
Sbjct: 1393 RLPVRWMAPETLSSAYFTTKSDVWSYGVVLWEIATFASLPYPGLSHEEVMKFVCDGGHLN 1452
Query: 922 --EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNF 959
E P L +M CW +PT R +F+E+ L +F
Sbjct: 1453 LPECPTKLPVILLTLMNMCWEFEPTNRLTFSEILSRLKSF 1492
>UniRef50_Q22489 Cluster: Putative uncharacterized protein; n=4;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 1086
Score = 142 bits (344), Expect = 5e-32
Identities = 75/188 (39%), Positives = 111/188 (59%), Gaps = 6/188 (3%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSM-YNNEEYQKKE 860
L +AF IA+GM Y+ ++K +H DLA RN LL + VKI DFGL R + E Y +
Sbjct: 835 LFEFAFDIAKGMNYMHSKKFIHRDLACRNCLLDEHLRVKIADFGLCRKVDIETELYVQMH 894
Query: 861 NSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDL-LRWL--SD 917
LPV+W E + ++ F SD+WS+G+V+WE+F+ TPY N++ L L WL S+
Sbjct: 895 ERDLPVRWFPPE-ISEQGFGITSDIWSFGVVIWELFTRGSTPYSNMASWILILPWLKESE 953
Query: 918 GNRLEKPPFADDRLY-NVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLNAPYN 976
NRL KPP+ ++LY +VML CW P RP F++L I+ N ++ E L A Y
Sbjct: 954 TNRLRKPPYCPEKLYTDVMLACWKANPAERPQFSDLVTIIPNVVKYMEGYDRSQLQAGYE 1013
Query: 977 EMNAELMT 984
+++ ++
Sbjct: 1014 RVSSRFLS 1021
>UniRef50_Q21041 Cluster: Putative uncharacterized protein ver-4; n=1;
Caenorhabditis elegans|Rep: Putative uncharacterized
protein ver-4 - Caenorhabditis elegans
Length = 1199
Score = 142 bits (344), Expect = 5e-32
Identities = 65/167 (38%), Positives = 102/167 (61%), Gaps = 2/167 (1%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
L + LL QIA GM++LAN +H DLA RNVL++ +++I DFGLA+ + Y
Sbjct: 997 LCTSDLLSIGLQIANGMDWLANIPCVHRDLACRNVLISKTKIIRIADFGLAKKHTDKAYY 1056
Query: 857 QKKEN--SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRW 914
+ +E+ +PLPV+W+ +E + D F+ +SDVWSYGI L+E+F+L TPYP+ L+ +
Sbjct: 1057 RVRESLDTPLPVRWMPLESITDLTFTQKSDVWSYGICLYEIFTLGGTPYPDCPNFSLVEY 1116
Query: 915 LSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
+ GN ++P +Y +M CW P RP+F E ++ N ++
Sbjct: 1117 IKTGNINKRPSNCHKDVYKIMKMCWQASPDDRPTFAECIKLFKNHIQ 1163
Score = 107 bits (257), Expect = 2e-21
Identities = 78/300 (26%), Positives = 135/300 (45%), Gaps = 28/300 (9%)
Query: 433 PIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTI 492
P + +S A G+ ++C+ GVP P W+KD GY +
Sbjct: 681 PFLLNNNSRSIISASNGQMFDINCKVNGVPTPDYTWFKD--------GYPY----TKGKV 728
Query: 493 VNSTFEIENMQEKDNGIYECVALNNASELRRAYTLVLKAEKSYTPYXXXXXXXXXXXXGM 552
+ + + +++DNGI+ C A N A + + S + + G+
Sbjct: 729 IGNALHVSKAEKRDNGIFWCSATNRAGTTIDYIEVKVAGASSSSFFWLFITFFAFVVVGI 788
Query: 553 VAYLFTWKLKKQREL--TKAGLLNFKSGN--------KKSFNPNLGIDEQADLLPYDEKF 602
V L WKL Q++L ++ L N K + N NL ++E+ D L Y+E +
Sbjct: 789 VVSLL-WKLFGQKDLKPSELSLNNLKRATDEYQKYTVSEKIN-NLPVEERIDYLTYNEDY 846
Query: 603 EFPREKLTFGKQLGAGAFGVVYKA----EARGIINAEVTTPVAVKMVKRTADNMYIKALA 658
E E L + LG+G FG+V K + E VA+K +++ K
Sbjct: 847 EIDLENLEILETLGSGQFGIVKKGYLNMASSKNFGFESRLSVAIKSSTDSSNMELQKMFF 906
Query: 659 SELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTD 718
ELK+M + KH N+++L+GA TK++ EL ++ E GN+ ++++ R+VF ++L +
Sbjct: 907 EELKLMCAIPKHPNVLSLVGAVTKNMEIGELFIVTELIDGGNLREFLRERRDVFANELVE 966
Score = 39.5 bits (88), Expect = 0.52
Identities = 31/124 (25%), Positives = 50/124 (40%), Gaps = 10/124 (8%)
Query: 252 LRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAKLLNN--RIIKRLENSEM-NF 308
L + ++ + Y + +NK + + V LLNN R I N +M +
Sbjct: 643 LNVRNITIDFTGTYYCIVKNKEFEHRFETSISVEKVSPPFLLNNNSRSIISASNGQMFDI 702
Query: 309 ACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYLKISVQASGVITCNAHNSKG 368
CKV G P PD TW + + + K +L+ K + +G+ C+A N G
Sbjct: 703 NCKVNGVPTPDYTWF---KDGYPYTKGKVIGNALHVS----KAEKRDNGIFWCSATNRAG 755
Query: 369 EYFD 372
D
Sbjct: 756 TTID 759
>UniRef50_O17408 Cluster: Putative uncharacterized protein; n=1;
Caenorhabditis elegans|Rep: Putative uncharacterized
protein - Caenorhabditis elegans
Length = 971
Score = 142 bits (344), Expect = 5e-32
Identities = 69/173 (39%), Positives = 105/173 (60%), Gaps = 4/173 (2%)
Query: 803 LGWAFQIARGMEYLANRKVLHGDLAARNVLLADD---NVVKICDFGLARSMYNNEEYQKK 859
L +A+QI +GM +L +++++H DLAARN+L+ + K+ DFGLA +E +
Sbjct: 657 LNFAWQITQGMRFLVDKRIIHRDLAARNILITEQCGMKSAKVSDFGLAILSEPSENGEVT 716
Query: 860 ENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGN 919
+ LP+KWLA+EC+ FS +SDVWS+GIV++EM+SL P+ I PT+L+ L G
Sbjct: 717 GSDRLPIKWLALECLEKAEFSFKSDVWSFGIVIFEMYSLGDVPFAEIEPTELIAHLKSGA 776
Query: 920 RLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLED-NERNRYVDL 971
R + P A D++ +M CW +K RP F EL ++ LE E Y++L
Sbjct: 777 RPKFPLLATDKIEEIMSSCWSEKSEERPDFDELSKLFATQLEQTTEGYGYLEL 829
>UniRef50_Q9Y1Y9 Cluster: Protein tyrosine kinase; n=3; Metazoa|Rep:
Protein tyrosine kinase - Ephydatia fluviatilis
Length = 2069
Score = 142 bits (343), Expect = 7e-32
Identities = 66/176 (37%), Positives = 108/176 (61%), Gaps = 3/176 (1%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLAD---DNVVKICDFGLARSM 850
P LT L+ A +A+G YL +H DLAARN L++ D VVKI DFGLA+ +
Sbjct: 1804 PPLLTVKELIQIALDVAQGCHYLQQTHFIHRDLAARNCLVSSKGADRVVKIGDFGLAKDL 1863
Query: 851 YNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTD 910
Y+++ YQ + LPV+W+A E ++ F+ +SDVWS+G+++WE+ + PYP ++ +
Sbjct: 1864 YSSDYYQVEGQRKLPVRWMAPEALLQGKFNMESDVWSFGVLMWEIMTFGNQPYPALNNQE 1923
Query: 911 LLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERN 966
+L++++ RL+KP ++Y +M CW + + R F ++EIL N+LE R+
Sbjct: 1924 VLQFVTAEGRLQKPENCPGKIYQLMQNCWKKVASERLHFDVIKEILNNYLEHLRRD 1979
Score = 41.1 bits (92), Expect = 0.17
Identities = 37/141 (26%), Positives = 65/141 (46%), Gaps = 10/141 (7%)
Query: 572 LLNFKSGNKKSFNPNLGID-EQADLLPYDEKFE----FPREKLTFGKQLGAGAFGVVYKA 626
L + + N K+++ N + D + DE E FPR L + G FG V++
Sbjct: 1660 LSDLRKKNVKAYSSNPQYAWSRDDYICTDEDLELLQKFPRGNLKLENFIDRGEFGEVFQG 1719
Query: 627 EARGIINAEV-TTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIA 685
A I+ PVAVK +++ A K +E +M + H NIV +LG C +
Sbjct: 1720 TATDILGPGTGPIPVAVKTLRKGAIIEEQKKFLAEAALMGNF-NHPNIVKVLGVC---VE 1775
Query: 686 KRELIVIVEYCKYGNIHNYMQ 706
+ +I+E G++ ++++
Sbjct: 1776 NDPVYIIMELMPGGDLLHFLR 1796
>UniRef50_Q9H3Y6 Cluster: Tyrosine-protein kinase Srms; n=17;
Amniota|Rep: Tyrosine-protein kinase Srms - Homo sapiens
(Human)
Length = 488
Score = 142 bits (343), Expect = 7e-32
Identities = 70/162 (43%), Positives = 99/162 (61%), Gaps = 1/162 (0%)
Query: 795 RPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNE 854
R L LLG+A Q+A GM YL ++V+H DLAARNVL+ D K+ DFGLAR + ++
Sbjct: 320 RALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLAR-LLKDD 378
Query: 855 EYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRW 914
Y +S +PVKW A E R+FS +SDVWS+G++L E+F+ + PY ++ + L+
Sbjct: 379 IYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQ 438
Query: 915 LSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEIL 956
+ G RL +P +Y +ML CW P RPSF L+E L
Sbjct: 439 IMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKL 480
>UniRef50_P08631 Cluster: Tyrosine-protein kinase HCK; n=32;
Euteleostomi|Rep: Tyrosine-protein kinase HCK - Homo
sapiens (Human)
Length = 526
Score = 142 bits (343), Expect = 7e-32
Identities = 65/163 (39%), Positives = 101/163 (61%), Gaps = 1/163 (0%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ ++ QIA GM ++ R +H DL A N+L++ V KI DFGLAR + +NE Y +E
Sbjct: 358 LIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNE-YTAREG 416
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
+ P+KW A E + F+ +SDVWS+GI+L E+ + + PYP +S +++R L G R+
Sbjct: 417 AKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRM 476
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
+P + LYN+M+RCW +P RP+F +Q +L +F E
Sbjct: 477 PRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATE 519
Score = 42.3 bits (95), Expect = 0.074
Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 13/107 (12%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+ +E PRE L K+LGAG FG V+ A T VAVK +K +M ++A +
Sbjct: 253 DAWEIPRESLKLEKKLGAGQFGEVWMA------TYNKHTKVAVKTMK--PGSMSVEAFLA 304
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
E +M L +H +V L T K + +I E+ G++ ++++
Sbjct: 305 EANVMKTL-QHDKLVKLHAVVT----KEPIYIITEFMAKGSLLDFLK 346
>UniRef50_Q4SK07 Cluster: Tyrosine-protein kinase receptor; n=2;
Tetraodontidae|Rep: Tyrosine-protein kinase receptor -
Tetraodon nigroviridis (Green puffer)
Length = 1084
Score = 141 bits (342), Expect = 9e-32
Identities = 65/164 (39%), Positives = 101/164 (61%), Gaps = 3/164 (1%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLA---DDNVVKICDFGLARSM 850
P LT LL A IA+G +YL + +H D+AARN LL V KI DFG+AR +
Sbjct: 601 PSSLTMVDLLNIARDIAKGCQYLEENQFIHRDIAARNCLLTCKGPGRVAKIGDFGMARDI 660
Query: 851 YNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTD 910
Y Y+K + LPVKW+ E ++ IF++++D WS+G++LWE+FSL PYP+ S +
Sbjct: 661 YRASYYRKGGRAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSRSNQE 720
Query: 911 LLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQE 954
+L ++++G R++ P +Y +M +CW +P RP+F+ + E
Sbjct: 721 VLEFVTNGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFSTILE 764
Score = 36.3 bits (80), Expect = 4.9
Identities = 27/107 (25%), Positives = 47/107 (43%), Gaps = 4/107 (3%)
Query: 603 EFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELK 662
E R ++ + LG GAFG VY+ A GI VAVK + E
Sbjct: 493 EVSRRNISLTRGLGHGAFGEVYEGLAVGIPGEPSPLQVAVKTLPEVCSEQDELDFLME-A 551
Query: 663 IMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+++ H NIV +G + + + +++E G++ +M++ R
Sbjct: 552 LIISKFSHQNIVRCVGVSLQAMPR---FILLELMTGGDLKTFMRETR 595
>UniRef50_Q7YXV8 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 865
Score = 141 bits (342), Expect = 9e-32
Identities = 65/144 (45%), Positives = 90/144 (62%)
Query: 809 IARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKW 868
IARGM Y +++ +H DLAARN LL D VKI DFGLAR++Y Y+ + LPVKW
Sbjct: 711 IARGMSYFVDQRFVHRDLAARNCLLDHDLTVKIGDFGLARNVYMTGYYKASTRAALPVKW 770
Query: 869 LAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFAD 928
+A E + D I + ++DVW+YG+ WE+FSL TPYP + +L L G RL KP
Sbjct: 771 MAPEMLRDGISNEKTDVWAYGVTCWEVFSLGSTPYPGVDNHLVLEHLMKGFRLAKPFLCF 830
Query: 929 DRLYNVMLRCWHQKPTARPSFTEL 952
++ Y ++ RCW P RP F+++
Sbjct: 831 EKNYQILQRCWSNNPGDRPCFSQI 854
Score = 39.1 bits (87), Expect = 0.69
Identities = 31/96 (32%), Positives = 47/96 (48%), Gaps = 6/96 (6%)
Query: 615 LGAGAFGVVYKAEARGIINAEVTTP-VAVKMVKRTADNMYIKALASELKIMVHLGKHVNI 673
+G GAFG VYK + AE + VA+K +K A I++ +E M +H NI
Sbjct: 595 IGEGAFGKVYKGL---LTQAESSVEHVAIKTIKIFAGIESIRSFFTECASMTSF-RHPNI 650
Query: 674 VNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L G C L+V+ + GN+ +Y+ K R
Sbjct: 651 IELFGMCFDAPDGTPLMVL-PFMINGNLKSYLVKSR 685
>UniRef50_P42685 Cluster: Tyrosine-protein kinase FRK; n=27;
Fungi/Metazoa group|Rep: Tyrosine-protein kinase FRK -
Homo sapiens (Human)
Length = 505
Score = 141 bits (342), Expect = 9e-32
Identities = 68/169 (40%), Positives = 103/169 (60%), Gaps = 4/169 (2%)
Query: 806 AFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLAR--SMYNNEEYQKKENSP 863
A Q+A GM YL +R +H DLAARNVL+ + N+ K+ DFGLAR + N + Y+ +
Sbjct: 335 AAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIK 394
Query: 864 LPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEK 923
LPVKW A E + FS +SDVWS+GI+L+E+ + K PY ++ +++ L+ RL +
Sbjct: 395 LPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQ 454
Query: 924 PPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLN 972
P + YN+ML CW+ +P RP+F L+ L ++ E + + Y D N
Sbjct: 455 PSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETD--SSYSDAN 501
Score = 46.0 bits (104), Expect = 0.006
Identities = 33/107 (30%), Positives = 57/107 (53%), Gaps = 12/107 (11%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+++E R + K+LG+G FG V++ G+ N TTPVAVK +K +M
Sbjct: 225 DQWEIDRNSIQLLKRLGSGQFGEVWE----GLWNN--TTPVAVKTLK--PGSMDPNDFLR 276
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
E +IM +L +H ++ L CT + + +I E ++G++ Y+Q
Sbjct: 277 EAQIMKNL-RHPKLIQLYAVCT---LEDPIYIITELMRHGSLQEYLQ 319
>UniRef50_P42684 Cluster: Tyrosine-protein kinase ABL2; n=38;
Euteleostomi|Rep: Tyrosine-protein kinase ABL2 - Homo
sapiens (Human)
Length = 1182
Score = 141 bits (342), Expect = 9e-32
Identities = 67/178 (37%), Positives = 102/178 (57%), Gaps = 2/178 (1%)
Query: 786 DYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFG 845
DY+ EC++ +T+ LL A QI+ MEYL + +H DLAARN L+ +++VVK+ DFG
Sbjct: 371 DYLRECNREE-VTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFG 429
Query: 846 LARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN 905
L+R M + Y + P+KW A E + FS +SDVW++G++LWE+ + +PYP
Sbjct: 430 LSRLM-TGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPG 488
Query: 906 ISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
I + + L G R+E+P ++Y +M CW P RPSF E + D+
Sbjct: 489 IDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDS 546
Score = 57.2 bits (132), Expect = 2e-06
Identities = 35/111 (31%), Positives = 57/111 (51%), Gaps = 11/111 (9%)
Query: 597 PYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKA 656
P +K+E R +T +LG G +G VY + + + VAVK +K D M ++
Sbjct: 276 PIHDKWEMERTDITMKHKLGGGQYGEVYVG-----VWKKYSLTVAVKTLKE--DTMEVEE 328
Query: 657 LASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQK 707
E +M + KH N+V LLG CT + ++ EY YGN+ +Y+++
Sbjct: 329 FLKEAAVMKEI-KHPNLVQLLGVCT---LEPPFYIVTEYMPYGNLLDYLRE 375
>UniRef50_UPI0000F2052A Cluster: PREDICTED: similar to anaplastic
lymphoma kinase (Ki-1),; n=1; Danio rerio|Rep: PREDICTED:
similar to anaplastic lymphoma kinase (Ki-1), - Danio
rerio
Length = 1387
Score = 141 bits (341), Expect = 1e-31
Identities = 67/172 (38%), Positives = 104/172 (60%), Gaps = 3/172 (1%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLA---DDNVVKICDFGLARSM 850
P LT LL A IARG +YL + +H D+AARN LL V KI DFG+AR +
Sbjct: 897 PSSLTMVDLLNIARDIARGCQYLEENQFIHRDIAARNCLLTCKGPGRVAKIGDFGMARDI 956
Query: 851 YNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTD 910
Y Y+K + LPVKW+ E ++ IF++++D WS+G++LWE+FSL PYP+ S +
Sbjct: 957 YRASYYRKGGRAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSRSNQE 1016
Query: 911 LLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLED 962
+L ++++G R++ P +Y +M + W +P RP+F+ + E + L+D
Sbjct: 1017 VLEFVTNGGRMDPPKNCPGPVYRIMTQSWQHQPEDRPNFSTILERIDYCLQD 1068
Score = 38.3 bits (85), Expect = 1.2
Identities = 27/107 (25%), Positives = 48/107 (44%), Gaps = 4/107 (3%)
Query: 603 EFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELK 662
E PR ++ + LG GAFG VY+ A GI VAVK + E
Sbjct: 789 EVPRRNISLTRGLGHGAFGEVYEGLAVGIPGEPSPMQVAVKTLPEVCSEQDELDFLME-A 847
Query: 663 IMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+++ H NIV +G + + +++E G++ +++++ R
Sbjct: 848 LIISKFSHQNIVRCIGVSLQALPH---FILLELMAGGDLKSFLRETR 891
>UniRef50_UPI0000E48358 Cluster: PREDICTED: hypothetical protein;
n=1; Strongylocentrotus purpuratus|Rep: PREDICTED:
hypothetical protein - Strongylocentrotus purpuratus
Length = 522
Score = 141 bits (341), Expect = 1e-31
Identities = 62/163 (38%), Positives = 102/163 (62%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
+++ L+ A QI GM YL ++++H DLA RN ++ +D +KI D L+R ++ ++ +
Sbjct: 352 ISTRDLVHLAIQITHGMMYLGKKRLVHKDLATRNCVIDEDYNLKITDNALSRDLFPSDYH 411
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
+N PVKW+A+E +V + FS SDVWS+G+ LWE+ +L +TPY ++ P ++ +L
Sbjct: 412 CLGDNENRPVKWMAVESLVHKKFSHASDVWSFGVTLWELVTLGQTPYMDLDPFEMATFLK 471
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNF 959
G R+ +PP D L+N+M CW P RP F++L L +F
Sbjct: 472 SGYRMPQPPSCPDELFNLMACCWALLPQDRPKFSQLCAALTDF 514
>UniRef50_Q6PUA9 Cluster: Receptor tyrosine kinase c-kit; n=1;
Ambystoma mexicanum|Rep: Receptor tyrosine kinase c-kit
- Ambystoma mexicanum (Axolotl)
Length = 959
Score = 141 bits (341), Expect = 1e-31
Identities = 102/292 (34%), Positives = 148/292 (50%), Gaps = 32/292 (10%)
Query: 454 LHCEAEGVPRPTIYWY---------KDD-----ELISNNSGYKLFVDIVNHTIVNSTFEI 499
L C A G P PTI WY D E + F I +V ST ++
Sbjct: 422 LQCVAAGFPAPTIDWYFCPGAEQGCTDSPAIPAEDVKQRPENSSFASI-GRIVVESTIDV 480
Query: 500 ENMQEKDNGIYECVALNNASELRRAYTLVLKAEKS----YTPYXXXXXXXXXXXXGMVAY 555
K NG +C+A N ++ ++ + S +TP VA
Sbjct: 481 SAF--KKNGTVQCIASNTVESTSSVFSFAIEEKISTHTLFTPLLIGFIVAAGLMCIAVAV 538
Query: 556 LFTWKLKKQRELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTFGKQL 615
L ++K + + +++ +GN + ID LPYD K+EFPR++L+FGK L
Sbjct: 539 LVYKYIQKPKYEDQWKVVDEINGNNYVY-----IDPTQ--LPYDHKWEFPRDRLSFGKIL 591
Query: 616 GAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVN 675
GAGAFG V +A A G+ + T VAVKM+K +A + +AL SELK++ +LG+H+NIVN
Sbjct: 592 GAGAFGRVVEATAYGLFKPDTTITVAVKMLKPSAHSTEREALMSELKVLSYLGQHINIVN 651
Query: 676 LLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFI-DQLTDNAEKNLGK 726
LLGACT +VI EYC YG++ NY+++ R+ FI ++ D AE L K
Sbjct: 652 LLGACT---VGGPTLVITEYCCYGDLLNYLRRKRDSFICPKIEDLAEMALYK 700
Score = 54.0 bits (124), Expect = 2e-05
Identities = 46/179 (25%), Positives = 86/179 (48%), Gaps = 13/179 (7%)
Query: 152 NITIRNATKKHN--GVYTCLLTNTCGEEKDEFRKIFLEKPFLSLRDLAKGKLMGNANKSI 209
N+T+ +++ + N G++TC N+ G +E F++L + + +A +S+
Sbjct: 267 NLTLSSSSVEVNDWGIFTCQARNSVGTSHASILLNVIEAGFINLFPVENASIEVHAGESL 326
Query: 210 NI-VIEIEAYP-PVERTHFLKNDKYLPSND--LKYNVTTLANGDPKLRINDLKLTDIANY 265
+ V+E EAYP P E ND L ++D +++ + +L + LK + Y
Sbjct: 327 VLRVVEYEAYPKPEEEFWTYMNDTVLNTSDHFVRFREEGNSRYISELHLIRLKGAERGIY 386
Query: 266 TLVAENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRLENSEMNFACKVTGYPLPDVTWIF 324
T +N + ++ V TKPE +L++ +RL+N + C G+P P + W F
Sbjct: 387 TFHVDNSDDSALMIFNILVKTKPE--ILSS---ERLDNGMLQ--CVAAGFPAPTIDWYF 438
>UniRef50_Q9U531 Cluster: Focal adhesion kinase homolog DFak56;
n=15; Sophophora|Rep: Focal adhesion kinase homolog
DFak56 - Drosophila melanogaster (Fruit fly)
Length = 1200
Score = 141 bits (341), Expect = 1e-31
Identities = 65/191 (34%), Positives = 108/191 (56%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
L+ G LL + +Q++ + YL ++K +H D+AARNVL++ VK+ DFGL+R + + Y
Sbjct: 577 LSHGTLLKYCYQLSTALSYLESKKFVHRDIAARNVLVSSPTCVKLADFGLSRWVSDQSYY 636
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
LP+KW++ E + R F+T SDVW +G+ +WE+ L P+ + +D++ L
Sbjct: 637 HSTPTVALPIKWMSPESINFRRFTTASDVWMFGVCIWEILMLGVKPFQGVKNSDVILKLE 696
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLNAPYN 976
+G RL PP RLY++M +CW +P RP+F ++E L L ++ N L
Sbjct: 697 NGERLPLPPNCPPRLYSLMSQCWAYEPLKRPNFKRIKETLHEILIEDSINSSETLKREQR 756
Query: 977 EMNAELMTGED 987
++ + G D
Sbjct: 757 KVASMSWIGSD 767
>UniRef50_O17391 Cluster: Protein kinase protein 9, isoform b; n=3;
Caenorhabditis|Rep: Protein kinase protein 9, isoform b
- Caenorhabditis elegans
Length = 615
Score = 141 bits (341), Expect = 1e-31
Identities = 71/173 (41%), Positives = 104/173 (60%), Gaps = 2/173 (1%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P L LL +++QI+ G+EYL N +H D+AARNVL+ N KI DFGL R + ++
Sbjct: 422 PDGLKIKDLLMFSWQISNGLEYLNNIGCIHRDIAARNVLVDSANTCKIGDFGLCR-LTDS 480
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
Y + LP+KW+A E + +S +SDVWSYG++LWE+FSL + PY + T+LL+
Sbjct: 481 LLYTAR-GGRLPLKWMAPESLATYEYSYKSDVWSYGVLLWELFSLGEVPYGEVQTTELLQ 539
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERN 966
G RL KP + + +Y+VM CW + P RP+F + +L LE+ N
Sbjct: 540 THRSGKRLLKPEWCPEEIYDVMRLCWQELPDDRPAFQQTCAVLAQMLENATEN 592
Score = 49.6 bits (113), Expect = 5e-04
Identities = 34/125 (27%), Positives = 65/125 (52%), Gaps = 14/125 (11%)
Query: 608 KLTFGKQLGAGAFGVVYKAEARG------IINAEVTT-----PVAVKMVKRTADNMYIKA 656
++ + K+LG+GAF V+K + G I + T PVAVKM+ AD+
Sbjct: 302 EINYSKKLGSGAFCNVFKGKINGEAPVSQIHPGQRTQLLRDCPVAVKMLPSFADDAARSD 361
Query: 657 LASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQL 716
E+ M L H ++V++LG ++ ++VE+C++G++ + ++ R+ I+
Sbjct: 362 FMQEINFMKSLAYHPHLVSMLGFVAD---RKSPYLLVEFCEHGDLLHMIRNRRQEIINGP 418
Query: 717 TDNAE 721
T+N +
Sbjct: 419 TENPD 423
>UniRef50_Q910A2 Cluster: Spleen protein tyrosine kinase; n=2; Danio
rerio|Rep: Spleen protein tyrosine kinase - Danio rerio
(Zebrafish) (Brachydanio rerio)
Length = 586
Score = 140 bits (340), Expect = 2e-31
Identities = 63/167 (37%), Positives = 101/167 (60%), Gaps = 1/167 (0%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
+T +L Q++ GM+YL +H DLAARNVLL + KI DFGL++++ +E Y
Sbjct: 417 ITVKNLTELVHQVSMGMKYLEEHNFVHRDLAARNVLLVTQHYAKISDFGLSKALTEDENY 476
Query: 857 QK-KENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
K K + P+KW A ECM FS++SDVWS+G+++WE FS + PY + ++++ +
Sbjct: 477 YKAKGHGKWPLKWYAPECMNYLKFSSKSDVWSFGVLMWEAFSYGQKPYKGMKGNEVIQMI 536
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLED 962
+G R+ PP +Y++M +CW KP RP F+ ++ L ++ D
Sbjct: 537 ENGQRMSAPPDCPPEMYDLMKKCWTYKPDERPGFSVVEPRLRHYYYD 583
Score = 48.4 bits (110), Expect = 0.001
Identities = 32/107 (29%), Positives = 56/107 (52%), Gaps = 11/107 (10%)
Query: 614 QLGAGAFGVVYKAEARGIINAEVTTPV-AVKMVKRTADNMYIK-ALASELKIMVHLGKHV 671
+LG+G FG V RG+ + T V AVK++K DN +K + E +M L
Sbjct: 327 ELGSGNFGTVL----RGVYQMKKTQKVVAVKILKNDDDNAAVKDEMLREANVMQQLDNPY 382
Query: 672 NIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTD 718
IV ++G C L++++E + G +H ++QK++ + + LT+
Sbjct: 383 -IVRMIGICEAE----NLMLVMELAELGPLHKFLQKNKHITVKNLTE 424
>UniRef50_Q4SQ93 Cluster: Tyrosine-protein kinase receptor; n=2;
Tetraodontidae|Rep: Tyrosine-protein kinase receptor -
Tetraodon nigroviridis (Green puffer)
Length = 822
Score = 140 bits (340), Expect = 2e-31
Identities = 63/163 (38%), Positives = 106/163 (65%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P LT +L A QIA GM YLA++ +H DLA RN L+ ++ +VKI DFG++R +Y+
Sbjct: 645 PVELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYST 704
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
+ Y+ ++ LP++W+ E ++ R F+T+SDVWS G+VLWE+F+ K P+ +S +++
Sbjct: 705 DYYRVGGHTMLPIRWMPPESIMYRRFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIE 764
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEIL 956
++ G L++P +Y++ML CWH++P R + E+ +L
Sbjct: 765 CITQGRVLQRPRTCPKEVYDLMLGCWHREPYMRLNIKEIYGML 807
Score = 38.3 bits (85), Expect = 1.2
Identities = 23/69 (33%), Positives = 35/69 (50%), Gaps = 6/69 (8%)
Query: 144 TTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEKDEFRKIFLEKP------FLSLRDLA 197
+T S + + + N T HNG+Y + TNT G+++ F+E P +LR L+
Sbjct: 331 STESEYHGCLQLVNPTHIHNGMYKLVATNTYGQDEKTVSAQFIEPPNFNHTGLAALRSLS 390
Query: 198 KGKLMGNAN 206
L GNAN
Sbjct: 391 TALLFGNAN 399
>UniRef50_Q70DV1 Cluster: Src tyrosine kinase; n=1; Schistosoma
mansoni|Rep: Src tyrosine kinase - Schistosoma mansoni
(Blood fluke)
Length = 647
Score = 140 bits (340), Expect = 2e-31
Identities = 74/191 (38%), Positives = 107/191 (56%), Gaps = 1/191 (0%)
Query: 774 YIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLL 833
YI E+ +K + + L L+ A +IA GM YL +R+ +H DLAARNVL+
Sbjct: 415 YIVTEYMSKGSLLNYLQSPEGNALNMQCLIMMAAKIAPGMAYLESRRHIHRDLAARNVLV 474
Query: 834 ADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLW 893
+ + VKI DFGLAR M +N EY + P+KW + E F+ +SDVWS+GI+L
Sbjct: 475 GEQHAVKIADFGLAR-MIHNREYVAHAGARFPIKWTSPEAANYSRFTIKSDVWSFGILLT 533
Query: 894 EMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQ 953
E+ + ++PYP + ++LR + G R+ KPP LY++ML CW RPSF +
Sbjct: 534 EIVTYGRSPYPGMHNAEVLRQVDAGYRMSKPPGCPPELYDLMLECWAADENKRPSFATIH 593
Query: 954 EILGNFLEDNE 964
L F ED +
Sbjct: 594 FRLEQFCEDEQ 604
Score = 44.8 bits (101), Expect = 0.014
Identities = 32/107 (29%), Positives = 54/107 (50%), Gaps = 12/107 (11%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+K+E P+ + +++G G FG V+KA + N TT VAVK +K ++ +
Sbjct: 337 DKWEIPKSSIILKEKIGQGQFGEVFKA----VWNK--TTIVAVKTLKPSSCD--AADFLR 388
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
E + M L H N++ L CT+ ++ EY G++ NY+Q
Sbjct: 389 EAQTMKRL-HHPNLIQLYAVCTQ---TEPFYIVTEYMSKGSLLNYLQ 431
>UniRef50_A6NNJ8 Cluster: Uncharacterized protein LTK; n=12;
Euarchontoglires|Rep: Uncharacterized protein LTK - Homo
sapiens (Human)
Length = 803
Score = 140 bits (339), Expect = 2e-31
Identities = 67/173 (38%), Positives = 101/173 (58%), Gaps = 3/173 (1%)
Query: 793 QPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLA---DDNVVKICDFGLARS 849
QP PL LL A IA+G YL +H D+AARN LL+ V KI DFG+AR
Sbjct: 550 QPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARD 609
Query: 850 MYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPT 909
+Y Y++ + + LPVKW+ E ++ IF++++D WS+G++LWE+FSL PYP +
Sbjct: 610 IYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQ 669
Query: 910 DLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLED 962
++L ++ G R++ P +Y +M +CW +P RPSF + E L +D
Sbjct: 670 EVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQD 722
>UniRef50_P04629 Cluster: High affinity nerve growth factor receptor
precursor; n=28; Eumetazoa|Rep: High affinity nerve
growth factor receptor precursor - Homo sapiens (Human)
Length = 796
Score = 140 bits (339), Expect = 2e-31
Identities = 64/159 (40%), Positives = 98/159 (61%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P PL G LL A Q+A GM YLA +H DLA RN L+ VVKI DFG++R +Y+
Sbjct: 619 PGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYST 678
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
+ Y+ + LP++W+ E ++ R F+T+SDVWS+G+VLWE+F+ K P+ +S T+ +
Sbjct: 679 DYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAID 738
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTEL 952
++ G LE+P +Y +M CW ++P R S ++
Sbjct: 739 CITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV 777
Score = 53.2 bits (122), Expect = 4e-05
Identities = 29/103 (28%), Positives = 57/103 (55%), Gaps = 5/103 (4%)
Query: 606 REKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMV 665
R + +LG GAFG V+ AE ++ + VAVK +K +++ + E +++
Sbjct: 507 RRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESAR-QDFQREAELLT 565
Query: 666 HLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKH 708
L +H +IV G CT+ R L+++ EY ++G+++ +++ H
Sbjct: 566 ML-QHQHIVRFFGVCTE---GRPLLMVFEYMRHGDLNRFLRSH 604
>UniRef50_P41240 Cluster: Tyrosine-protein kinase CSK; n=21;
Deuterostomia|Rep: Tyrosine-protein kinase CSK - Homo
sapiens (Human)
Length = 450
Score = 140 bits (339), Expect = 2e-31
Identities = 73/185 (39%), Positives = 107/185 (57%), Gaps = 9/185 (4%)
Query: 774 YIQQEWQTKYEGDYI-YECHQPRPLTSGH-LLGWAFQIARGMEYLANRKVLHGDLAARNV 831
YI E+ K G + Y + R + G LL ++ + MEYL +H DLAARNV
Sbjct: 263 YIVTEYMAK--GSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNV 320
Query: 832 LLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIV 891
L+++DNV K+ DFGL + + ++ K LPVKW A E + ++ FST+SDVWS+GI+
Sbjct: 321 LVSEDNVAKVSDFGLTKEASSTQDTGK-----LPVKWTAPEALREKKFSTKSDVWSFGIL 375
Query: 892 LWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTE 951
LWE++S + PYP I D++ + G +++ P +Y VM CWH RPSF +
Sbjct: 376 LWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQ 435
Query: 952 LQEIL 956
L+E L
Sbjct: 436 LREQL 440
>UniRef50_P13368 Cluster: Protein sevenless; n=20; Eumetazoa|Rep:
Protein sevenless - Drosophila melanogaster (Fruit fly)
Length = 2554
Score = 140 bits (339), Expect = 2e-31
Identities = 68/191 (35%), Positives = 107/191 (56%), Gaps = 10/191 (5%)
Query: 793 QPRP---LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDN-------VVKIC 842
+P+P L+ LL +A G YL + +H DLA RN L+ + VKI
Sbjct: 2308 EPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIG 2367
Query: 843 DFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTP 902
DFGLAR +Y ++ Y+K+ LPV+W++ E +VD +F+TQSDVW++G++ WE+ +L + P
Sbjct: 2368 DFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQP 2427
Query: 903 YPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLED 962
Y + ++L + +G RL++PP ++LY+++L CW P RPSF L D
Sbjct: 2428 YAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAISTD 2487
Query: 963 NERNRYVDLNA 973
R + A
Sbjct: 2488 LRRTQMASATA 2498
Score = 42.7 bits (96), Expect = 0.056
Identities = 31/113 (27%), Positives = 59/113 (52%), Gaps = 7/113 (6%)
Query: 615 LGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIV 674
LG+GAFG VY+ + + ++E VA+K +++ A L E ++M + KH NIV
Sbjct: 2215 LGSGAFGEVYEGQLK-TEDSEEPQRVAIKSLRKGASE--FAELLQEAQLMSNF-KHENIV 2270
Query: 675 NLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDNAEKNLGKI 727
L+G C + +I+E+ + G++ +Y++ R + A +L ++
Sbjct: 2271 CLVGIC---FDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSEL 2320
>UniRef50_Q9N4T2 Cluster: Putative uncharacterized protein Y50D4B.6;
n=1; Caenorhabditis elegans|Rep: Putative
uncharacterized protein Y50D4B.6 - Caenorhabditis
elegans
Length = 421
Score = 140 bits (338), Expect = 3e-31
Identities = 72/178 (40%), Positives = 105/178 (58%), Gaps = 11/178 (6%)
Query: 795 RPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNE 854
R L LL +AFQIA GM++L N +H DLA RNV + + +++I DFGLAR N E
Sbjct: 218 RLLCPTDLLSFAFQIANGMKFLGNVACVHRDLALRNVFVKRNRIIRIADFGLARWHENKE 277
Query: 855 EYQKKENSPLPVKWLAIECMV-----DRI-FSTQSDVWSYGIVLWEMFSLAKTPYPNIS- 907
Y+KK + P+KWLA EC + I F ++SD+WSYG+ L+E+FSL +PY +
Sbjct: 278 YYRKKTDVGFPMKWLAPECFEFEQERENIKFDSKSDIWSYGVCLYEIFSLGVSPYEGLDF 337
Query: 908 -P---TDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
P L++++ DGN+L P D++Y M CW+ P RP F+E ++ L+
Sbjct: 338 RPDYFQGLMKYVRDGNQLPSPEHGSDKIYEFMQSCWNLNPDKRPVFSECRDFFQKLLQ 395
Score = 55.6 bits (128), Expect = 7e-06
Identities = 36/123 (29%), Positives = 64/123 (52%), Gaps = 10/123 (8%)
Query: 596 LPYDEKFEFPREKLTFGKQ--LGAGAFGVVYKA----EARGIINAEVTTPVAVKMVKRTA 649
L +DE+FE K +F LG G +G V+K + + +++E + VAVK R
Sbjct: 88 LKFDERFEIDVNKFSFYNLSFLGNGYYGKVFKERMHKKQKNGLDSENSLEVAVKRALRPE 147
Query: 650 DNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
D + + EL +M +GKH NI+ L+ + I E++++ E+ + G++ Y++ R
Sbjct: 148 DPSEQQLMCEELNVMCVVGKHPNILALI----RWIRTNEILIVSEFVEKGDLVEYLRARR 203
Query: 710 EVF 712
F
Sbjct: 204 RYF 206
>UniRef50_Q26566 Cluster: Epidermal growth factor receptor precursor;
n=5; Schistosoma|Rep: Epidermal growth factor receptor
precursor - Schistosoma mansoni (Blood fluke)
Length = 1717
Score = 140 bits (338), Expect = 3e-31
Identities = 69/175 (39%), Positives = 102/175 (58%), Gaps = 1/175 (0%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
L S LL WA QIA GM YL R ++H DLAARNVL+ V+I DFGLA+ + +E
Sbjct: 1156 LNSLTLLSWAEQIADGMSYLEMRGIIHRDLAARNVLVQTREHVQITDFGLAKMLERRDED 1215
Query: 857 QK-KENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
+ +P++WLAIE + I+S ++DVWSYG+ LWE+F+ K PY ++ D+ +
Sbjct: 1216 SVIVKAGRVPIRWLAIETLQYGIYSHKTDVWSYGVTLWEIFTFGKRPYEDVDTVDIKDHV 1275
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVD 970
G RL +P +Y V+++CW + +RP+F EL F + R Y++
Sbjct: 1276 IKGGRLTQPDICTLDVYMVLVKCWMEDYESRPTFIELMRTFNTFCKTPGRYLYIE 1330
>UniRef50_O77132 Cluster: Non-receptor protein-tyrosine kinase CSK;
n=1; Hydra vulgaris|Rep: Non-receptor protein-tyrosine
kinase CSK - Hydra attenuata (Hydra) (Hydra vulgaris)
Length = 467
Score = 140 bits (338), Expect = 3e-31
Identities = 67/155 (43%), Positives = 94/155 (60%), Gaps = 5/155 (3%)
Query: 804 GWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSP 863
G+A + GM YL + ++H DLAARNVLL+D+ K+ DFGLA+ + Q+ +
Sbjct: 311 GFAIDVCNGMRYLEEKNIIHRDLAARNVLLSDELCAKVSDFGLAKDVE-----QELASGK 365
Query: 864 LPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEK 923
PVKW A E + +IFST+SDVWS+GI+LWE+FS + PYP +LL + R+E
Sbjct: 366 FPVKWTAPEAIELKIFSTKSDVWSFGILLWEIFSFGRNPYPREPLDELLTKIKSNYRMEC 425
Query: 924 PPFADDRLYNVMLRCWHQKPTARPSFTELQEILGN 958
P +Y +ML+CW P+ RPSF +L L N
Sbjct: 426 PEKCPPFVYQLMLKCWDADPSRRPSFKQLHNELFN 460
Score = 36.3 bits (80), Expect = 4.9
Identities = 31/107 (28%), Positives = 54/107 (50%), Gaps = 13/107 (12%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
E + P E + F + +G G FG VYK + A+ T VA+K K D+ ++L +
Sbjct: 204 EGWAVPIEDVEFKELIGKGEFGNVYKG-----VWAKKT--VAIK--KLRDDSKTAQSLLA 254
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
E +M L +H N+V L+ ++++ EYC+ G + Y++
Sbjct: 255 EASVMTTL-QHKNLVVLVAI---SFQGDSILILTEYCEKGVLVEYLR 297
>UniRef50_Q16620 Cluster: BDNF/NT-3 growth factors receptor
precursor; n=73; Gnathostomata|Rep: BDNF/NT-3 growth
factors receptor precursor - Homo sapiens (Human)
Length = 822
Score = 140 bits (338), Expect = 3e-31
Identities = 63/169 (37%), Positives = 106/169 (62%)
Query: 790 ECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARS 849
E + P LT +L A QIA GM YLA++ +H DLA RN L+ ++ +VKI DFG++R
Sbjct: 641 EGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRD 700
Query: 850 MYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPT 909
+Y+ + Y+ ++ LP++W+ E ++ R F+T+SDVWS G+VLWE+F+ K P+ +S
Sbjct: 701 VYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNN 760
Query: 910 DLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGN 958
+++ ++ G L++P +Y +ML CW ++P R + + +L N
Sbjct: 761 EVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQN 809
Score = 55.6 bits (128), Expect = 7e-06
Identities = 32/103 (31%), Positives = 56/103 (54%), Gaps = 5/103 (4%)
Query: 606 REKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMV 665
R + ++LG GAFG V+ AE + + VAVK +K +DN K E +++
Sbjct: 535 RHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNAR-KDFHREAELLT 593
Query: 666 HLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKH 708
+L +H +IV G C + LI++ EY K+G+++ +++ H
Sbjct: 594 NL-QHEHIVKFYGVC---VEGDPLIMVFEYMKHGDLNKFLRAH 632
Score = 36.7 bits (81), Expect = 3.7
Identities = 13/58 (22%), Positives = 30/58 (51%)
Query: 459 EGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIYECVALN 516
+G P+P + W+ + +++ + + + NHT + +++N +NG Y +A N
Sbjct: 308 KGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKN 365
Score = 36.3 bits (80), Expect = 4.9
Identities = 26/79 (32%), Positives = 35/79 (44%), Gaps = 5/79 (6%)
Query: 302 ENSEMNFACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYLKISVQASG-VIT 360
E + +C V G P+P++ W N ++ T Q SL IS SG I+
Sbjct: 210 EGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSL----RITNISSDDSGKQIS 265
Query: 361 CNAHNSKGEYFDSSTLLVY 379
C A N GE DS L V+
Sbjct: 266 CVAENLVGEDQDSVNLTVH 284
>UniRef50_Q16XX9 Cluster: Tyrosine-protein kinase shark; n=2;
Culicidae|Rep: Tyrosine-protein kinase shark - Aedes
aegypti (Yellowfever mosquito)
Length = 939
Score = 139 bits (337), Expect = 4e-31
Identities = 62/149 (41%), Positives = 92/149 (61%), Gaps = 1/149 (0%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQK-KE 860
L+ WA QIA GM+YL +H DLAARN+LLA N KI DFGL+R++ ++Y + +
Sbjct: 761 LVIWAAQIACGMQYLEQHHFVHRDLAARNILLASRNQAKISDFGLSRAIGAGDDYYRASQ 820
Query: 861 NSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNR 920
P+KW A E FS SDVWS+G+ +WEM+SL PY ++ D+++ + +G R
Sbjct: 821 GGKWPIKWYAPESFNYGTFSHASDVWSFGVTMWEMYSLGAPPYQDMKGVDVIKLIENGQR 880
Query: 921 LEKPPFADDRLYNVMLRCWHQKPTARPSF 949
L +P + ++ VM CW+ P +RP+F
Sbjct: 881 LSQPDLCPENVFEVMKNCWNYNPKSRPTF 909
Score = 37.9 bits (84), Expect = 1.6
Identities = 24/76 (31%), Positives = 37/76 (48%), Gaps = 2/76 (2%)
Query: 605 PREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIM 664
P+E + K LG G FG VY+ R ++ TP+A+K + + E +M
Sbjct: 654 PKECILTQKVLGRGEFGYVYQGLLRPQEPSD-CTPIAIKQLVESTGKRNRVDFLREASVM 712
Query: 665 VHLGKHVNIVNLLGAC 680
+ L +H IV L+G C
Sbjct: 713 IRL-RHHCIVKLIGIC 727
>UniRef50_P03949 Cluster: Tyrosine-protein kinase abl-1; n=5;
Caenorhabditis|Rep: Tyrosine-protein kinase abl-1 -
Caenorhabditis elegans
Length = 1224
Score = 139 bits (337), Expect = 4e-31
Identities = 65/165 (39%), Positives = 98/165 (59%), Gaps = 1/165 (0%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ A QIA GM YL R +H DLAARN L+++ N+VKI DFGLAR M + Y
Sbjct: 409 LVQMASQIASGMSYLEARHFIHRDLAARNCLVSEHNIVKIADFGLARFM-KEDTYTAHAG 467
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
+ P+KW A E + FS++SDVW++G++LWE+ + PYP + +++ L +G R+
Sbjct: 468 AKFPIKWTAPEGLAFNTFSSKSDVWAFGVLLWEIATYGMAPYPGVELSNVYGLLENGFRM 527
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERN 966
+ P +Y +ML+CW+ P+ RP F ++ L N + N N
Sbjct: 528 DGPQGCPPSVYRLMLQCWNWSPSDRPRFRDIHFNLENLISSNSLN 572
Score = 43.2 bits (97), Expect = 0.042
Identities = 35/108 (32%), Positives = 54/108 (50%), Gaps = 11/108 (10%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+++E R ++ +LG G +G VY+ G T +AVK +K D M + +
Sbjct: 302 DEWELDRSEIIMHNKLGGGQYGDVYE----GYWKRHDCT-IAVKALKE--DAMPLHEFLA 354
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQK 707
E IM L H N+V LLG CT H A +I E+ GN+ Y+++
Sbjct: 355 EAAIMKDL-HHKNLVRLLGVCT-HEA--PFYIITEFMCNGNLLEYLRR 398
>UniRef50_Q4SMB8 Cluster: Chromosome 3 SCAF14553, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 3 SCAF14553, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 606
Score = 139 bits (336), Expect = 5e-31
Identities = 64/157 (40%), Positives = 92/157 (58%)
Query: 809 IARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKW 868
++ GM YL R+++H DLAARNVL+ N +KI DFGLAR + NE+ + +P+KW
Sbjct: 1 MSEGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLDANEKEYNADGGKMPIKW 60
Query: 869 LAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFAD 928
+A+EC+ R F+ QSDVWSYG+ +WE+ + PY I ++ L G RL +PP
Sbjct: 61 MALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDILEKGERLPQPPICT 120
Query: 929 DRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNER 965
+Y VM++CW +RP F EL D +R
Sbjct: 121 IDVYMVMVKCWMIDADSRPKFKELAAEFCRMARDPQR 157
>UniRef50_Q24145 Cluster: Tyrosine-protein kinase shark; n=2;
Sophophora|Rep: Tyrosine-protein kinase shark -
Drosophila melanogaster (Fruit fly)
Length = 939
Score = 139 bits (336), Expect = 5e-31
Identities = 71/169 (42%), Positives = 96/169 (56%), Gaps = 2/169 (1%)
Query: 787 YIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGL 846
YI + H + L WA QIA GM YL ++ +H DLAARN+LL + KI DFG+
Sbjct: 752 YILD-HGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGM 810
Query: 847 ARSMY-NNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN 905
+RS+ + EYQ + P++W A E IFS SDVWS+G+ +WEMFSL PY
Sbjct: 811 SRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGE 870
Query: 906 ISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQE 954
IS D ++ + G RL +P +Y VM CW ++P RP+F L E
Sbjct: 871 ISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLTE 919
Score = 36.7 bits (81), Expect = 3.7
Identities = 36/124 (29%), Positives = 58/124 (46%), Gaps = 15/124 (12%)
Query: 601 KFEFPREKLTFGKQLGAGAFGVVYKA--EARGIINAEVTTPVAVKMVKRTADNMYIKALA 658
+F EKL +++G G FG V+ + E VA+KM+ N +
Sbjct: 654 RFFIEPEKLVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHSNK--QEFL 711
Query: 659 SELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIV-EYCKYGNIHNYMQKHREVFIDQLT 717
E +M+ L +H IV L+G IAK E++++V E G++ Y+ H ++T
Sbjct: 712 REASVMMRL-EHKCIVRLIG-----IAKGEMLMMVQELAPLGSMLQYILDHGH----EIT 761
Query: 718 DNAE 721
NAE
Sbjct: 762 ANAE 765
>UniRef50_P00521 Cluster: Tyrosine-protein kinase transforming
protein Abl; n=15; root|Rep: Tyrosine-protein kinase
transforming protein Abl - Abelson murine leukemia virus
Length = 746
Score = 139 bits (336), Expect = 5e-31
Identities = 63/178 (35%), Positives = 106/178 (59%), Gaps = 2/178 (1%)
Query: 786 DYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFG 845
DY+ EC++ + +++ LL A QI+ MEYL + +H DLAARN L+ ++++VK+ DFG
Sbjct: 211 DYLRECNR-QEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFG 269
Query: 846 LARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN 905
L+R M + Y + P+KW A E + FS +SDVW++G++LWE+ + +PYP
Sbjct: 270 LSRLM-TGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPG 328
Query: 906 ISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
I + + L R+E+P +++Y +M CW P+ RPSF E+ + +++
Sbjct: 329 IDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES 386
Score = 57.2 bits (132), Expect = 2e-06
Identities = 35/111 (31%), Positives = 59/111 (53%), Gaps = 11/111 (9%)
Query: 597 PYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKA 656
P +K+E R +T +LG G +G VY+ + + + VAVK +K D M ++
Sbjct: 116 PNYDKWEMERTDITMKHKLGGGQYGEVYEG-----VWKKYSLTVAVKTLKE--DTMEVEE 168
Query: 657 LASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQK 707
E +M + KH N+V LLG CT+ + +I E+ YGN+ +Y+++
Sbjct: 169 FLKEAAVMKEI-KHPNLVQLLGVCTR---EPPFYIITEFMTYGNLLDYLRE 215
>UniRef50_UPI0000E48523 Cluster: PREDICTED: similar to
protein-tyrosine kinase; n=3; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to protein-tyrosine
kinase - Strongylocentrotus purpuratus
Length = 837
Score = 138 bits (335), Expect = 6e-31
Identities = 65/160 (40%), Positives = 95/160 (59%), Gaps = 1/160 (0%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSM-YNNEE 855
+T+ L WA QIA GM YL +K +H DLAARN+LL + KI DFGL+R+ NN+
Sbjct: 656 ITASDLKLWATQIASGMMYLEGKKFVHRDLAARNILLENKGQAKISDFGLSRATGANNDY 715
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
Y+ PVKW A E + FS SDVW +G+ LWEM S PY + ++++ +
Sbjct: 716 YRSTTGGRWPVKWYAPESIYYGTFSHSSDVWGFGVTLWEMNSRGAQPYGEKTGAEVIKQI 775
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEI 955
+G+RL +P +Y +M +CW KP RP+F++L ++
Sbjct: 776 ENGHRLNRPEGCPQNVYQIMNKCWSYKPCNRPTFSQLNDM 815
>UniRef50_P00519 Cluster: Proto-oncogene tyrosine-protein kinase
ABL1; n=35; root|Rep: Proto-oncogene tyrosine-protein
kinase ABL1 - Homo sapiens (Human)
Length = 1130
Score = 138 bits (335), Expect = 6e-31
Identities = 63/178 (35%), Positives = 105/178 (58%), Gaps = 2/178 (1%)
Query: 786 DYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFG 845
DY+ EC++ + + + LL A QI+ MEYL + +H DLAARN L+ ++++VK+ DFG
Sbjct: 325 DYLRECNR-QEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFG 383
Query: 846 LARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN 905
L+R M + Y + P+KW A E + FS +SDVW++G++LWE+ + +PYP
Sbjct: 384 LSRLM-TGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPG 442
Query: 906 ISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
I + + L R+E+P +++Y +M CW P+ RPSF E+ + +++
Sbjct: 443 IDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES 500
Score = 57.2 bits (132), Expect = 2e-06
Identities = 35/111 (31%), Positives = 59/111 (53%), Gaps = 11/111 (9%)
Query: 597 PYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKA 656
P +K+E R +T +LG G +G VY+ + + + VAVK +K D M ++
Sbjct: 230 PNYDKWEMERTDITMKHKLGGGQYGEVYEG-----VWKKYSLTVAVKTLKE--DTMEVEE 282
Query: 657 LASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQK 707
E +M + KH N+V LLG CT+ + +I E+ YGN+ +Y+++
Sbjct: 283 FLKEAAVMKEI-KHPNLVQLLGVCTR---EPPFYIITEFMTYGNLLDYLRE 329
>UniRef50_Q24488 Cluster: Tyrosine-protein kinase transmembrane
receptor Ror precursor; n=1; Drosophila
melanogaster|Rep: Tyrosine-protein kinase transmembrane
receptor Ror precursor - Drosophila melanogaster (Fruit
fly)
Length = 685
Score = 138 bits (334), Expect = 8e-31
Identities = 63/167 (37%), Positives = 102/167 (61%)
Query: 795 RPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNE 854
+ L+ L A QI+ GM+YL+ +H DLAARN L+ + VVKI DFGL+R +Y+++
Sbjct: 509 KSLSQLEFLQIALQISEGMQYLSAHHYVHRDLAARNCLVNEGLVVKISDFGLSRDIYSSD 568
Query: 855 EYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRW 914
Y+ + S LPV+W+ E ++ F+T+SDVWS+G+VLWE++S PY S +++
Sbjct: 569 YYRVQSKSLLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINL 628
Query: 915 LSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
+ L P +Y++M+ CWH++ RP+FT++ L + E
Sbjct: 629 IRSRQLLSAPENCPTAVYSLMIECWHEQSVKRPTFTDISNRLKTWHE 675
Score = 47.2 bits (107), Expect = 0.003
Identities = 31/102 (30%), Positives = 53/102 (51%), Gaps = 6/102 (5%)
Query: 604 FPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKI 663
F + + F ++LG GAFG VYK + + + T VA+K +K A + E+++
Sbjct: 405 FTLQDVEFLEELGEGAFGKVYKGQL--LQPNKTTITVAIKALKENASVKTQQDFKREIEL 462
Query: 664 MVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYM 705
+ L KH NIV +LG + K ++ EY G++H ++
Sbjct: 463 ISDL-KHQNIVCILGVV---LNKEPYCMLFEYMANGDLHEFL 500
>UniRef50_P08923 Cluster: Leukocyte tyrosine kinase receptor
precursor; n=8; Amniota|Rep: Leukocyte tyrosine kinase
receptor precursor - Mus musculus (Mouse)
Length = 888
Score = 138 bits (334), Expect = 8e-31
Identities = 65/165 (39%), Positives = 99/165 (60%), Gaps = 3/165 (1%)
Query: 793 QPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLA---DDNVVKICDFGLARS 849
Q PLT LL A IA+G YL +H D+AARN LL+ V KI DFG+AR
Sbjct: 607 QLAPLTMQDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCSGASRVAKIGDFGMARD 666
Query: 850 MYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPT 909
+Y Y+K + LPVKW+ E +++ +F++++D WS+G++LWE+FSL PYP +
Sbjct: 667 IYQASYYRKGGRTLLPVKWMPPEALLEGLFTSKTDSWSFGVLLWEIFSLGYMPYPGHTNQ 726
Query: 910 DLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQE 954
++L +++ GNR++ P +Y +M +CW +P RP F + E
Sbjct: 727 EVLDFIATGNRMDPPRNCPGPVYRIMTQCWQHQPELRPDFGSILE 771
>UniRef50_P34891 Cluster: Receptor-like tyrosine-protein kinase
kin-15 precursor; n=3; Caenorhabditis elegans|Rep:
Receptor-like tyrosine-protein kinase kin-15 precursor -
Caenorhabditis elegans
Length = 488
Score = 138 bits (334), Expect = 8e-31
Identities = 69/172 (40%), Positives = 104/172 (60%), Gaps = 2/172 (1%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
L + LL +++QIA GMEYLA+ +H DLA RNVLL + ++I DFGLAR + Y
Sbjct: 291 LCTSDLLSFSYQIAEGMEYLASIPCVHRDLALRNVLLNKNKTIRIADFGLARKYQVDGYY 350
Query: 857 Q--KKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRW 914
+ K +P+P +W+A E M + + +SDVWSYG+ L+EMFSL + PY N+S +D+
Sbjct: 351 RITKGVGTPMPARWMAPEVMREGKCTEKSDVWSYGVSLYEMFSLGELPYSNVSNSDVFEH 410
Query: 915 LSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERN 966
+ GN+L P + ++Y+ M + W+ T RPSF++ E L + N
Sbjct: 411 VVQGNQLPMPQYCHPKMYDRMKQFWNFDATFRPSFSKCVEFFEEHLSVSATN 462
Score = 65.3 bits (152), Expect = 9e-09
Identities = 46/158 (29%), Positives = 82/158 (51%), Gaps = 8/158 (5%)
Query: 572 LLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTFGK-QLGAGAFG-VVYKAEAR 629
LL+ S N+++ I+E+ + L +D +FE + KL + +LG+G FG V Y +
Sbjct: 106 LLDVTSVNEETPIVKRPINERIENLEFDPRFEIDQAKLEISEDKLGSGFFGEVCYGLLSM 165
Query: 630 GIINAEVTT----PVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIA 685
N E T VAVK K + E K+M +G++ NI+ ++GA T +
Sbjct: 166 RTSNTETDTLQKLSVAVKQSNDPTQENQEKMIEDETKLMCAIGRNPNILAIIGAVTANSG 225
Query: 686 KRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDNAEKN 723
++IVE+ + G++ ++++ + +F D+L EKN
Sbjct: 226 SARNLLIVEFVECGDLLKFLEEKKSIFKDELV--YEKN 261
>UniRef50_Q07912 Cluster: Activated CDC42 kinase 1; n=24;
Euteleostomi|Rep: Activated CDC42 kinase 1 - Homo
sapiens (Human)
Length = 1036
Score = 138 bits (334), Expect = 8e-31
Identities = 65/159 (40%), Positives = 100/159 (62%), Gaps = 2/159 (1%)
Query: 800 GHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSM-YNNEEYQK 858
G L +A Q+A GM YL +++ +H DLAARN+LLA ++VKI DFGL R++ N++ Y
Sbjct: 227 GTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVM 286
Query: 859 KENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL-SD 917
+E+ +P W A E + R FS SD W +G+ LWEMF+ + P+ ++ + +L + +
Sbjct: 287 QEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKE 346
Query: 918 GNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEIL 956
G RL +P +YNVM++CW KP RP+F L++ L
Sbjct: 347 GERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFL 385
>UniRef50_Q8T0W6 Cluster: Putative insulin receptor precursor; n=1;
Echinococcus multilocularis|Rep: Putative insulin
receptor precursor - Echinococcus multilocularis
Length = 1749
Score = 138 bits (333), Expect = 1e-30
Identities = 67/155 (43%), Positives = 93/155 (60%), Gaps = 3/155 (1%)
Query: 805 WAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPL 864
WA QIA GM YL +K +H DLAARN L+ VVK+ DFGL R +Y Y K L
Sbjct: 1458 WAVQIADGMAYLERKKYVHRDLAARNCLVDGRGVVKVGDFGLCRDIYERNYYHKVGAGKL 1517
Query: 865 PVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEK- 923
PV+W+A E + F+++SDVWS+G+VLWE+ ++A PY +S +++ ++ DGN L
Sbjct: 1518 PVRWMAPESLQSAYFTSRSDVWSFGVVLWEIATMACLPYQGMSHNEVISYVLDGNTLVSG 1577
Query: 924 --PPFADDRLYNVMLRCWHQKPTARPSFTELQEIL 956
P L +VML CW +P RP+F L +L
Sbjct: 1578 GAPINCPPLLQSVMLYCWSYRPAQRPTFLHLLYLL 1612
>UniRef50_Q6R1Y3 Cluster: Src family kinase; n=6; Fungi/Metazoa
group|Rep: Src family kinase - Asterina miniata (Bat
star) (Patiria miniata)
Length = 563
Score = 138 bits (333), Expect = 1e-30
Identities = 67/179 (37%), Positives = 108/179 (60%), Gaps = 3/179 (1%)
Query: 786 DYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFG 845
DY++E + + L L+ Q+A GM YL +++ +H DLAARN+L+ D K+ DFG
Sbjct: 384 DYLHE-GEGKQLREPELIDITAQVADGMAYLESQRFVHRDLAARNILVGDLRNCKVADFG 442
Query: 846 LARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN 905
L+R + +EY KE + +P+KW A E + F+ +SDVWS+GI+++E+ + + PYP
Sbjct: 443 LSRII--EDEYIAKEGAKMPIKWTAPEAINFGKFTIKSDVWSFGILIYEVITKGRVPYPG 500
Query: 906 ISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
+ ++L +S G R+ KPP D+LY++ +CW P RP+F L L +F +E
Sbjct: 501 MVNREVLDQVSRGYRMPKPPECPDQLYDITKQCWDAVPEKRPTFEFLHSFLDDFYHASE 559
Score = 37.1 bits (82), Expect = 2.8
Identities = 31/106 (29%), Positives = 49/106 (46%), Gaps = 12/106 (11%)
Query: 602 FEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASEL 661
+E PR + ++LG G FG V++ G T VAVK +K A M A E
Sbjct: 295 WEIPRRSIKLERKLGNGQFGEVWEGTWNG------TVRVAVKTLKEGA--MDPTAFLQEA 346
Query: 662 KIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQK 707
IM L +H +V LL C++ + ++ E G + +Y+ +
Sbjct: 347 NIMKKL-RHPKLVALLAVCSE---GEPIYIVTELMTNGCLLDYLHE 388
>UniRef50_Q5I4E2 Cluster: Bm-DAF-2 precursor; n=1; Brugia malayi|Rep:
Bm-DAF-2 precursor - Brugia malayi (Filarial nematode
worm)
Length = 1456
Score = 138 bits (333), Expect = 1e-30
Identities = 82/253 (32%), Positives = 135/253 (53%), Gaps = 8/253 (3%)
Query: 805 WAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPL 864
WA Q+A GM YL + K H DLAARN ++ + + VKI DFG+AR +Y +E Y+ +
Sbjct: 1163 WASQVADGMAYLESLKFCHRDLAARNCMVNEFDTVKIGDFGMARDIYYHEYYKPAGKRLM 1222
Query: 865 PVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNR-LEK 923
PV+W+A E ++D F+ +SDVWSYGI L+EM +LA+ PY ++ + ++ + L +
Sbjct: 1223 PVRWMAPESLMDGKFTMKSDVWSYGITLYEMLTLAQQPYLGLANESVFDYIGVKKKILTR 1282
Query: 924 PPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLNAPYNEMNAELM 983
P D Y +M RCW P RP+F ++ IL E N D + + + M
Sbjct: 1283 PTGCPDFWYELMKRCWKYDPRERPTFAQIVGILLRHAEGGILNFPDDEFREMSFVMSNQM 1342
Query: 984 TGEDYLAMVCAP--DYNNIV-TPSPNYVNMAKSFFPATPTPKDQEGYLPMSPTSDQTKYM 1040
+DYL P D + +V T S +V+ +++ F P ++ L S +S +Y+
Sbjct: 1343 NTDDYLDEELFPITDSSRLVRTASAGHVDQSETSFINRP----EKQQLNHSSSSGNIRYL 1398
Query: 1041 AHGTKFDFDSRKL 1053
++ + + + +
Sbjct: 1399 SNNNEANIQPKPI 1411
Score = 35.9 bits (79), Expect = 6.4
Identities = 31/120 (25%), Positives = 52/120 (43%), Gaps = 7/120 (5%)
Query: 592 QADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTT--PVAVKMVKRTA 649
Q D+ DE +E R + ++G G FG VY+ + T A+K V TA
Sbjct: 1028 QMDVYKPDE-WELKRSAIHLEDEIGRGTFGKVYRGYGDNCKSYLGVTFGECAIKTVSETA 1086
Query: 650 DNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
++ E +M IV L G + + ++V++E K GN+ +Y++ R
Sbjct: 1087 NSAERLHFLIEASVMKQFNTPF-IVKLYGVVSD---GQPVLVVMEMMKKGNLRDYLRSRR 1142
>UniRef50_P42680 Cluster: Tyrosine-protein kinase Tec; n=86;
Coelomata|Rep: Tyrosine-protein kinase Tec - Homo
sapiens (Human)
Length = 631
Score = 138 bits (333), Expect = 1e-30
Identities = 62/163 (38%), Positives = 98/163 (60%), Gaps = 1/163 (0%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
LL + GMEYL +H DLAARN L+++ VVK+ DFG+AR + + ++Y
Sbjct: 466 LLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLD-DQYTSSSG 524
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
+ PVKW E FS++SDVWS+G+++WE+F+ + P+ + +++ ++ G+RL
Sbjct: 525 AKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRL 584
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
+P A + +Y VMLRCW +KP RPSF +L + +E E
Sbjct: 585 YQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECEE 627
Score = 47.6 bits (108), Expect = 0.002
Identities = 33/113 (29%), Positives = 60/113 (53%), Gaps = 12/113 (10%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
EK+E +LTF ++LG+G FGVV + R VA+K ++ A M +
Sbjct: 361 EKWEINPSELTFMRELGSGLFGVVRLGKWR------AQYKVAIKAIREGA--MCEEDFIE 412
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVF 712
E K+M+ L H +V L G CT+ ++ + ++ E+ + G + N++++ + F
Sbjct: 413 EAKVMMKL-THPKLVQLYGVCTQ---QKPIYIVTEFMERGCLLNFLRQRQGHF 461
>UniRef50_Q9TX48 Cluster: 220 kDa ABL-related protein tyrosine
kinase; n=3; Strongylocentrotus purpuratus|Rep: 220 kDa
ABL-related protein tyrosine kinase - Strongylocentrotus
purpuratus (Purple sea urchin)
Length = 200
Score = 137 bits (332), Expect = 1e-30
Identities = 66/169 (39%), Positives = 100/169 (59%), Gaps = 1/169 (0%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
LL A Q+A GM YL +H DLAARN LL + +++K+ DFGLAR M E Y +
Sbjct: 25 LLYMATQVAFGMSYLEKNSFIHRDLAARNCLLGEHHLLKVADFGLAR-MVQGEIYTAQAG 83
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
+ P+KW A E + FS++SDVW++GI+LWE+ + +PYP + + L G R+
Sbjct: 84 AKFPIKWTAPESLAYVKFSSKSDVWAFGILLWEIATYGCSPYPGVDLQHVYGKLEQGYRM 143
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVD 970
E+P +Y +M +CW + T RPSFTE+ E + N +++ + V+
Sbjct: 144 ERPEAVLRNVYKLMHKCWEWRHTDRPSFTEIHEEMNNMFQNSSISEEVE 192
>UniRef50_Q7Q5T3 Cluster: Tyrosine-protein kinase receptor; n=3;
Endopterygota|Rep: Tyrosine-protein kinase receptor -
Anopheles gambiae str. PEST
Length = 646
Score = 137 bits (332), Expect = 1e-30
Identities = 63/162 (38%), Positives = 101/162 (62%)
Query: 806 AFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLP 865
A QI GMEYLA+ +H DLAARN L+ D+ VKI DFGL+R +Y+++ Y+ + S LP
Sbjct: 484 AQQICDGMEYLASHHYVHRDLAARNCLVGDNLTVKISDFGLSRDIYSSDYYRVQSKSLLP 543
Query: 866 VKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPP 925
V+W+ E ++ F+T+SDVWS+G+VLWE++S PY S +++ + L P
Sbjct: 544 VRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGLQPYYGYSNQEVINMVRARQLLPCPE 603
Query: 926 FADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNR 967
+Y++M+ CWH++ RP+F E+ L + + +R++
Sbjct: 604 SCPSAVYSLMVECWHEQAVRRPTFPEIGHRLKIWYQAQKRSK 645
Score = 47.2 bits (107), Expect = 0.003
Identities = 32/103 (31%), Positives = 52/103 (50%), Gaps = 6/103 (5%)
Query: 603 EFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELK 662
++ + + F ++LG GAFG VYK E + VAVK +K A E++
Sbjct: 368 QYTLQDVRFVEELGEGAFGKVYKGELTQKNGERIF--VAVKALKENASAKTQADFKREIE 425
Query: 663 IMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYM 705
++ L KH NIV +LG K + L ++ EY G++H ++
Sbjct: 426 LISDL-KHDNIVCILGVVLK---EEPLCMLFEYMAQGDLHEFL 464
>UniRef50_Q70W05 Cluster: Src protein; n=1; Ciona intestinalis|Rep:
Src protein - Ciona intestinalis (Transparent sea
squirt)
Length = 355
Score = 137 bits (332), Expect = 1e-30
Identities = 63/158 (39%), Positives = 92/158 (58%)
Query: 795 RPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNE 854
+ L L+ A Q+A GM YL +H DLAARN+L+ +N+ KI DFGLAR N+
Sbjct: 184 KDLNEDTLIEMAIQVATGMVYLEVNDYIHRDLAARNILVGKNNICKIADFGLARVTQGND 243
Query: 855 EYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRW 914
YQ K + P++W A E + F+ +SDVWS+GI+L E+ + PY ++L
Sbjct: 244 IYQAKVGAEFPIRWTAPEAATMQQFTIKSDVWSFGILLTEIIGNGRVPYAGFQTFEVLEQ 303
Query: 915 LSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTEL 952
+ G R+EK ++LY++M+ CWH+ P RPSF L
Sbjct: 304 VERGYRMEKLEKCSEQLYDIMMACWHKDPNQRPSFESL 341
>UniRef50_Q6NP28 Cluster: LP09923p; n=6; Endopterygota|Rep: LP09923p
- Drosophila melanogaster (Fruit fly)
Length = 847
Score = 137 bits (332), Expect = 1e-30
Identities = 64/149 (42%), Positives = 94/149 (63%), Gaps = 5/149 (3%)
Query: 805 WAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPL 864
+A+ A GMEYL +KV+H DLAARNVL+++D V K+ DFGLAR EE + L
Sbjct: 693 FAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR-----EECYNLDVGKL 747
Query: 865 PVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKP 924
P+KW A E + + FS +SD+WS+GI+LWE++S + PYP I D+++ + G ++E P
Sbjct: 748 PIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAP 807
Query: 925 PFADDRLYNVMLRCWHQKPTARPSFTELQ 953
+Y +M + W P RP+F EL+
Sbjct: 808 EGCPPEIYEMMRQAWDLNPAKRPTFAELK 836
>UniRef50_Q17MF5 Cluster: Tyrosine-protein kinase; n=2;
Culicidae|Rep: Tyrosine-protein kinase - Aedes aegypti
(Yellowfever mosquito)
Length = 747
Score = 137 bits (331), Expect = 2e-30
Identities = 64/160 (40%), Positives = 98/160 (61%), Gaps = 5/160 (3%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
+T + +AF GMEYL +KV+H DLAARNVL++++ V K+ DFGLAR +E
Sbjct: 580 ITRRDQINFAFDTCSGMEYLEMKKVIHRDLAARNVLISEECVAKVSDFGLAR-----DER 634
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
+ S LP+KW A E + + FS ++D+WS+GI+LWE++S + PYP I D+++ +
Sbjct: 635 YTADISKLPIKWTAPEALKEGKFSNKTDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVG 694
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEIL 956
G ++E P +Y +M + W P RP+F EL+ L
Sbjct: 695 SGYKMEAPEGCPPEIYEMMRQAWDLVPEKRPTFAELKRRL 734
>UniRef50_P42679 Cluster: Megakaryocyte-associated tyrosine-protein
kinase; n=38; Euteleostomi|Rep: Megakaryocyte-associated
tyrosine-protein kinase - Homo sapiens (Human)
Length = 507
Score = 137 bits (331), Expect = 2e-30
Identities = 65/164 (39%), Positives = 103/164 (62%), Gaps = 5/164 (3%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
+ + LL ++ +A GMEYL ++K++H DLAARN+L+++D V K+ DFGLA++ E
Sbjct: 324 VNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKA-----ER 378
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
+ ++S LPVKW A E + F+++SDVWS+G++LWE+FS + PYP +S ++ +
Sbjct: 379 KGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVE 438
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFL 960
G R+E P ++ +M CW +P RP F +L E L L
Sbjct: 439 KGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLAREL 482
Score = 41.9 bits (94), Expect = 0.098
Identities = 31/108 (28%), Positives = 53/108 (49%), Gaps = 15/108 (13%)
Query: 607 EKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVH 666
+ LT G Q+G G FG V + E G VAVK +K ++ +A E +M
Sbjct: 233 QHLTLGAQIGEGEFGAVLQGEYLG-------QKVAVKNIK---CDVTAQAFLDETAVMTK 282
Query: 667 LGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFID 714
+ +H N+V LLG I + L +++E+ GN+ N+++ ++
Sbjct: 283 M-QHENLVRLLGV----ILHQGLYIVMEHVSKGNLVNFLRTRGRALVN 325
>UniRef50_O02742 Cluster: Activated CDC42 kinase 2; n=13;
Euteleostomi|Rep: Activated CDC42 kinase 2 - Bos taurus
(Bovine)
Length = 747
Score = 137 bits (331), Expect = 2e-30
Identities = 65/159 (40%), Positives = 99/159 (62%), Gaps = 2/159 (1%)
Query: 800 GHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSM-YNNEEYQK 858
G L +A Q+A GM YL ++ +H DLAARN+LLA ++VKI DFGL R++ N++ Y
Sbjct: 227 GTLSRYAVQVAEGMGYLEAKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVM 286
Query: 859 KENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL-SD 917
+E+ +P W A E + R FS SD W +G+ LWEMF+ + P+ ++ + +L + +
Sbjct: 287 QEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKE 346
Query: 918 GNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEIL 956
G RL +P +YNVM++CW KP RP+F L++ L
Sbjct: 347 GERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFL 385
>UniRef50_Q4S351 Cluster: Chromosome 4 SCAF14752, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 4 SCAF14752, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 810
Score = 136 bits (330), Expect = 2e-30
Identities = 70/173 (40%), Positives = 98/173 (56%), Gaps = 2/173 (1%)
Query: 785 GDYI-YECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
GD++ Y + L + LL +A A GM YL ++ +H DLAARN L+ D+N +KI D
Sbjct: 633 GDFLSYLRKKKDELKTKQLLRFAVDAAAGMAYLESKNCIHRDLAARNCLVGDNNALKISD 692
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FG++R ++ Y +P+KW A E + +S++SDVWSYGI+LWE FSL PY
Sbjct: 693 FGMSRQE-DDGIYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSYGILLWETFSLGMCPY 751
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEIL 956
P ++ + G R+ P D +Y VM RCW P RP F+ELQ L
Sbjct: 752 PGMTNQQAREQVEKGYRMACPQRCPDDVYKVMQRCWQYNPEDRPKFSELQRDL 804
Score = 50.8 bits (116), Expect = 2e-04
Identities = 34/112 (30%), Positives = 58/112 (51%), Gaps = 9/112 (8%)
Query: 599 DEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALA 658
D+K+ E + G+ LG G FG V+K G + + TPVAVK K +
Sbjct: 542 DKKWILNHEDVVLGELLGKGNFGEVFK----GTLQRD-KTPVAVKTCKEDLPSELKIRFL 596
Query: 659 SELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHRE 710
SE +I+ H NIV L+G CT+ ++ + +++E G+ +Y++K ++
Sbjct: 597 SEARILKQY-DHPNIVKLIGVCTQ---RQPIYIVMELVPGGDFLSYLRKKKD 644
>UniRef50_Q5TUS8 Cluster: Tyrosine-protein kinase receptor; n=1;
Anopheles gambiae str. PEST|Rep: Tyrosine-protein kinase
receptor - Anopheles gambiae str. PEST
Length = 2075
Score = 136 bits (330), Expect = 2e-30
Identities = 63/168 (37%), Positives = 99/168 (58%), Gaps = 4/168 (2%)
Query: 793 QPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLAD----DNVVKICDFGLAR 848
Q LT L+ +A G YL +H DLA RN L++ D VVKI DFGLAR
Sbjct: 1905 QAARLTMLDLISMCQDVASGCRYLEEMHFVHRDLACRNCLVSSTDPRDRVVKIGDFGLAR 1964
Query: 849 SMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISP 908
+Y N+ Y+K+ LPV+W++ E +VD +F++QSD+W++G++LWE+ +L + PY +
Sbjct: 1965 DIYKNDYYRKEGEGLLPVRWMSPESLVDGVFTSQSDIWAFGVLLWEIMTLGEQPYQAKNN 2024
Query: 909 TDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEIL 956
++L + +G L++P + +Y +M CW P RP+F E+L
Sbjct: 2025 VEVLNHVREGGHLDRPKVCPNEMYELMKYCWKFSPEERPTFRYCLEVL 2072
Score = 57.2 bits (132), Expect = 2e-06
Identities = 43/152 (28%), Positives = 76/152 (50%), Gaps = 10/152 (6%)
Query: 560 KLKKQRELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGA 619
+L REL + G NF ++ D + LLP + + + LG+GA
Sbjct: 1761 ELANLRELPRRG--NFVQTTNILYSSGSMTDSEIALLP---RIRLDQIFMASSSLLGSGA 1815
Query: 620 FGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGA 679
FG VY+ +G ++ E T VA+K +K+ A + E ++M + KH +I LLG
Sbjct: 1816 FGEVYEGVVKG-VDGEAETRVAIKTLKKGAKLHEKQEFLQEAQLMSNF-KHKHITRLLGV 1873
Query: 680 CTKHIAKRELIVIVEYCKYGNIHNYMQKHREV 711
C + A L++I+E + G++ +Y+++ R +
Sbjct: 1874 CLEADA---LLIIMELMQGGDLLSYLRRSRSL 1902
>UniRef50_Q17C76 Cluster: Focal adhesion kinase; n=2; Culicidae|Rep:
Focal adhesion kinase - Aedes aegypti (Yellowfever
mosquito)
Length = 1092
Score = 136 bits (330), Expect = 2e-30
Identities = 62/170 (36%), Positives = 101/170 (59%), Gaps = 1/170 (0%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
L G LL +++Q++ + YL ++K +H D+AARNVL++ +K+ DFGL+R + ++ Y
Sbjct: 552 LKLGTLLLYSYQLSTALSYLESKKFVHRDIAARNVLVSSPTCIKLADFGLSRWV-EDQSY 610
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
LP+KW+A E + R F+T SDVW +G+ WE+ L P+ I D++ L
Sbjct: 611 YTSTKGMLPIKWMAPESINFRRFTTASDVWMFGVCTWEILMLGVKPFQGIKNCDVIGKLE 670
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERN 966
+G RL PP RLY++M +CW +P RP+F ++E+L L + +
Sbjct: 671 NGERLPLPPNCPPRLYSLMSQCWSYEPHKRPNFKNIKEVLYEILTEERHS 720
>UniRef50_O76148 Cluster: Tyrosine-protein kinase receptor; n=1;
Anopheles sp.|Rep: Tyrosine-protein kinase receptor -
Anopheles sp
Length = 863
Score = 136 bits (330), Expect = 2e-30
Identities = 63/168 (37%), Positives = 99/168 (58%), Gaps = 4/168 (2%)
Query: 793 QPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLAD----DNVVKICDFGLAR 848
Q LT L+ +A G YL +H DLA RN L++ D VVKI DFGLAR
Sbjct: 550 QAARLTMLDLISMCQDVASGCRYLEEMHFVHRDLACRNCLVSSTDPRDRVVKIGDFGLAR 609
Query: 849 SMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISP 908
+Y N+ Y+K+ LPV+W++ E +VD +F++QSD+W++G++LWE+ +L + PY +
Sbjct: 610 DIYKNDYYRKEGEGLLPVRWMSPESLVDGVFTSQSDIWAFGVLLWEIMTLGEQPYQAKNN 669
Query: 909 TDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEIL 956
++L + +G L++P + +Y +M CW P RP+F E+L
Sbjct: 670 VEVLNHVREGGHLDRPKVCPNEMYELMKYCWKFSPEERPTFRYCLEVL 717
Score = 50.8 bits (116), Expect = 2e-04
Identities = 31/91 (34%), Positives = 53/91 (58%), Gaps = 5/91 (5%)
Query: 615 LGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIV 674
LG+GAFG VY+ +G ++ E T VA+K +K+ A + E ++M + KH +I
Sbjct: 457 LGSGAFGEVYEGVVKG-VDGEAETRVAIKTLKKGAKLHEKQEFLQEAQLMSNF-KHKHIT 514
Query: 675 NLLGACTKHIAKRELIVIVEYCKYGNIHNYM 705
LLG C + A L++I+E + G++ +Y+
Sbjct: 515 RLLGVCLEADA---LLIIMELMQGGDLLSYL 542
>UniRef50_Q08881 Cluster: Tyrosine-protein kinase ITK/TSK; n=18;
Euteleostomi|Rep: Tyrosine-protein kinase ITK/TSK - Homo
sapiens (Human)
Length = 620
Score = 136 bits (330), Expect = 2e-30
Identities = 62/160 (38%), Positives = 95/160 (59%), Gaps = 1/160 (0%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
LLG + GM YL V+H DLAARN L+ ++ V+K+ DFG+ R + + ++Y
Sbjct: 459 LLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLD-DQYTSSTG 517
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
+ PVKW + E +S++SDVWS+G+++WE+FS K PY N S ++++ +S G RL
Sbjct: 518 TKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRL 577
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
KP A +Y +M CW ++P RP+F+ L L E
Sbjct: 578 YKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAE 617
Score = 39.1 bits (87), Expect = 0.69
Identities = 28/112 (25%), Positives = 59/112 (52%), Gaps = 12/112 (10%)
Query: 601 KFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASE 660
K+ +LTF +++G+G FG+V+ +N + VA+K ++ A M + E
Sbjct: 355 KWVIDPSELTFVQEIGSGQFGLVHLGY---WLNKD---KVAIKTIREGA--MSEEDFIEE 406
Query: 661 LKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVF 712
++M+ L H +V L G C + + + ++ E+ ++G + +Y++ R +F
Sbjct: 407 AEVMMKL-SHPKLVQLYGVC---LEQAPICLVFEFMEHGCLSDYLRTQRGLF 454
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.316 0.133 0.396
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 1,388,773,228
Number of Sequences: 1657284
Number of extensions: 63422790
Number of successful extensions: 190465
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 3762
Number of HSP's successfully gapped in prelim test: 4900
Number of HSP's that attempted gapping in prelim test: 166007
Number of HSP's gapped (non-prelim): 21773
length of query: 1158
length of database: 575,637,011
effective HSP length: 109
effective length of query: 1049
effective length of database: 394,993,055
effective search space: 414347714695
effective search space used: 414347714695
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.6 bits)
S2: 78 (35.5 bits)
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