Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001183-TA|BGIBMGA001183-PA|IPR003599|Immunoglobulin
subtype, IPR003598|Immunoglobulin subtype 2, IPR001245|Tyrosine
protein kinase, IPR002290|Serine/threonine protein kinase,
IPR000719|Protein kinase, IPR008266|Tyrosine protein kinase, active
site, IPR013838|Beta tubulin, autoregulation binding site,
IPR001824|Receptor tyrosine kinase, class III,
IPR007110|Immunoglobulin-like, IPR011009|Protein kinase-like,
IPR013151|Immunoglobulin, IPR013098|Immunoglobulin I-set
(1158 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
X51602-1|CAA35946.1| 1338|Homo sapiens protein ( Human flt mRNA ... 343 2e-93
AL139005-1|CAI17096.1| 1338|Homo sapiens fms-related tyrosine ki... 343 2e-93
AL138712-1|CAI14846.1| 1338|Homo sapiens fms-related tyrosine ki... 343 2e-93
AF063657-1|AAC16449.2| 1338|Homo sapiens vascular endothelial gr... 343 2e-93
BC131822-1|AAI31823.1| 1356|Homo sapiens kinase insert domain re... 337 1e-91
AF063658-1|AAC16450.1| 1356|Homo sapiens vascular endothelial gr... 336 3e-91
AF035121-1|AAB88005.1| 1356|Homo sapiens KDR/flk-1 protein protein. 336 3e-91
AB209901-1|BAD93138.1| 1451|Homo sapiens kinase insert domain re... 336 3e-91
X61656-1|CAA43837.1| 1354|Homo sapiens membrane protein protein. 332 6e-90
L04947-1|AAA59459.1| 1354|Homo sapiens receptor tyrosine kinase ... 332 6e-90
DQ836395-1|ABI53804.1| 556|Homo sapiens N2idVEGFR-1 protein. 312 6e-84
DQ836394-1|ABI53803.1| 556|Homo sapiens idVEGFR-1 protein. 312 6e-84
AB209050-1|BAD92287.1| 551|Homo sapiens fms-related tyrosine ki... 311 1e-83
M22734-1|AAA60048.1| 1089|Homo sapiens platelet-derived growth f... 289 4e-77
M21574-1|AAA96715.1| 1089|Homo sapiens platelet-derived growth f... 289 4e-77
D50017-1|BAA08742.1| 1089|Homo sapiens alpha-platelet-derived gr... 289 4e-77
AY229892-1|AAP69563.1| 849|Homo sapiens FIP1L1/PDGFRA fusion pr... 280 2e-74
U63834-2|AAC50969.1| 972|Homo sapiens KIT protein protein. 279 4e-74
X69301-1|CAA49159.1| 976|Homo sapiens mast/stem cell growth fa... 277 2e-73
X06182-1|CAA29548.1| 976|Homo sapiens protein ( Human c-kit pro... 277 2e-73
U63834-1|AAC50968.1| 976|Homo sapiens KIT protein protein. 277 2e-73
BC071593-1|AAH71593.1| 976|Homo sapiens KIT protein protein. 276 4e-73
M21616-1|AAA36427.1| 1106|Homo sapiens platelet-derived growth f... 265 5e-70
J03278-1|AAA60049.1| 1106|Homo sapiens platelet-derived growth f... 265 5e-70
BC032224-1|AAH32224.1| 1106|Homo sapiens platelet-derived growth... 265 5e-70
AB209657-1|BAD92894.1| 777|Homo sapiens platelet-derived growth... 265 5e-70
Z26652-1|CAA81393.1| 993|Homo sapiens FLT3 receptor tyrosine ki... 263 3e-69
U02687-1|AAA18947.1| 993|Homo sapiens serine/threonine protein ... 263 3e-69
BC126350-1|AAI26351.1| 993|Homo sapiens fms-related tyrosine ki... 263 3e-69
X03663-1|CAA27300.1| 972|Homo sapiens protein ( Human mRNA for ... 262 4e-69
U63963-1|AAB51696.1| 972|Homo sapiens CSF-1 receptor protein. 262 4e-69
BC047521-1|AAH47521.1| 972|Homo sapiens colony stimulating fact... 261 9e-69
AL591024-3|CAH70634.1| 996|Homo sapiens fms-related tyrosine ki... 257 2e-67
AL445262-1|CAI17231.1| 996|Homo sapiens fms-related tyrosine ki... 257 2e-67
AL356915-1|CAI12447.1| 996|Homo sapiens fms-related tyrosine ki... 257 2e-67
M64347-1|AAA58470.1| 731|Homo sapiens fgflr protein. 204 2e-51
M58051-1|AAA52450.1| 806|Homo sapiens fibroblast growth factor ... 204 2e-51
BC128610-1|AAI28611.1| 480|Homo sapiens FGFR3 protein protein. 204 2e-51
BC121175-1|AAI21176.1| 480|Homo sapiens FGFR3 protein protein. 204 2e-51
AY768549-1|AAU89726.1| 806|Homo sapiens fibroblast growth facto... 204 2e-51
AF487554-2|AAM22078.1| 769|Homo sapiens fibroblast growth facto... 204 2e-51
AF487554-1|AAM22079.1| 771|Homo sapiens fibroblast growth facto... 204 2e-51
AF245114-1|AAF63380.1| 694|Homo sapiens fibroblast growth facto... 204 2e-51
Y00665-1|CAA68679.1| 622|Homo sapiens tyrosine kinase protein. 198 9e-50
X66945-1|CAA47375.1| 822|Homo sapiens fibroblast growth factor ... 198 9e-50
X57122-1|CAA40404.1| 731|Homo sapiens Fibroblast Growth Factor ... 198 9e-50
X57121-1|CAA40403.1| 822|Homo sapiens Fibroblast Growth Factor ... 198 9e-50
X57120-1|CAA40402.1| 820|Homo sapiens Fibroblast Growth Factor ... 198 9e-50
X57119-1|CAA40401.1| 733|Homo sapiens Fibroblast Growth Factor ... 198 9e-50
X52833-1|CAA37015.1| 822|Homo sapiens protein ( Human flg mRNA ... 198 9e-50
X51803-1|CAA36101.1| 822|Homo sapiens protein ( Human mRNA for ... 198 9e-50
M63887-1|AAA35958.1| 822|Homo sapiens heparin-binding growth fa... 198 9e-50
M60485-1|AAA35840.1| 820|Homo sapiens fibroblast growth factor ... 198 9e-50
M37722-1|AAA75007.1| 731|Homo sapiens basic fibroblast growth f... 198 9e-50
M34641-1|AAA35835.1| 820|Homo sapiens protein ( Human fibroblas... 198 9e-50
M34186-1|AAA35837.1| 731|Homo sapiens protein ( Human fibroblas... 198 9e-50
M34185-1|AAA35836.1| 733|Homo sapiens protein ( Human fibroblas... 198 9e-50
BC091494-1|AAH91494.1| 731|Homo sapiens fibroblast growth facto... 198 9e-50
BC018128-1|AAH18128.1| 820|Homo sapiens fibroblast growth facto... 198 9e-50
BC015035-1|AAH15035.1| 820|Homo sapiens FGFR1 protein protein. 198 9e-50
AY585209-1|AAS79322.1| 822|Homo sapiens fibroblast growth facto... 198 9e-50
AK222718-1|BAD96438.1| 820|Homo sapiens fibroblast growth facto... 198 9e-50
AB208919-1|BAD92156.1| 814|Homo sapiens fibroblast growth facto... 198 9e-50
X68203-1|CAA48290.1| 1304|Homo sapiens FTL4 protein. 193 3e-48
U43143-1|AAA85215.1| 1298|Homo sapiens Flt4 protein. 193 3e-48
AY233383-1|AAO89505.1| 1363|Homo sapiens VEGFR3 long form protein. 192 5e-48
AY233382-1|AAO89504.1| 1298|Homo sapiens VEGFR3 short form protein. 192 5e-48
X69878-1|CAA49505.1| 1298|Homo sapiens protein ( H.sapiens Flt4 ... 191 1e-47
Z71929-1|CAA96492.1| 821|Homo sapiens FGFR2 protein. 190 2e-47
X52832-1|CAA37014.1| 821|Homo sapiens protein ( Human bek mRNA ... 190 2e-47
M97193-1|AAA52449.1| 822|Homo sapiens fibroblast growth factor ... 190 2e-47
M87771-1|AAA59471.1| 705|Homo sapiens fibroblast growth factor ... 190 2e-47
M87770-1|AAA59470.1| 821|Homo sapiens fibroblast growth factor ... 190 2e-47
M55614-1|AAA61188.1| 822|Homo sapiens TK14 protein protein. 190 2e-47
BC039243-1|AAH39243.2| 704|Homo sapiens FGFR2 protein protein. 190 2e-47
AF487553-1|AAM74056.1| 822|Homo sapiens fibroblast growth facto... 190 2e-47
AF360695-2|AAK94205.1| 819|Homo sapiens keratinocyte growth fac... 190 2e-47
AF360695-1|AAK94206.1| 820|Homo sapiens keratinocyte growth fac... 190 2e-47
AB084153-1|BAC45037.1| 709|Homo sapiens isoform of FGFR2 protein. 190 2e-47
DQ493927-1|ABE96832.1| 785|Homo sapiens fibroblast growth facto... 190 3e-47
AF360695-3|AAK94209.1| 785|Homo sapiens keratinocyte growth fac... 190 3e-47
Y13901-1|CAA74200.1| 802|Homo sapiens fibroblast growth factor ... 189 6e-47
X57205-1|CAA40490.1| 802|Homo sapiens fibroblast growth factor ... 189 6e-47
L03840-1|AAB59389.1| 802|Homo sapiens fibroblast growth factor ... 189 6e-47
EF571596-1|ABQ01235.1| 802|Homo sapiens fibroblast growth facto... 189 6e-47
BC011847-1|AAH11847.1| 802|Homo sapiens fibroblast growth facto... 189 6e-47
AF487555-1|AAM13666.1| 802|Homo sapiens fibroblast growth facto... 189 6e-47
AF359246-1|AAK51435.1| 592|Homo sapiens fibroblast growth facto... 189 6e-47
AF202063-1|AAF27432.1| 762|Homo sapiens fibroblast growth facto... 189 6e-47
AB209631-1|BAD92868.1| 1034|Homo sapiens Fibroblast growth facto... 189 6e-47
M80634-1|AAA36147.1| 822|Homo sapiens keratinocyte growth facto... 187 2e-46
X56348-1|CAA39792.1| 435|Homo sapiens urf-ret protein. 186 3e-46
X15786-1|CAA33787.1| 899|Homo sapiens retII protein. 186 3e-46
X12949-1|CAA31408.1| 860|Homo sapiens protein ( Human ret proto... 186 3e-46
M31213-1|AAA36524.1| 503|Homo sapiens protein ( Human papillary... 186 3e-46
DQ104207-1|AAZ57203.1| 776|Homo sapiens HOOK3-RET fusion protei... 186 3e-46
M16029-1|AAA36786.1| 805|Homo sapiens protein ( Human ret mRNA ... 186 4e-46
L03357-1|AAA60266.1| 593|Homo sapiens RET tyrosine kinase/cAMP ... 186 4e-46
BC004257-1|AAH04257.1| 1072|Homo sapiens ret proto-oncogene prot... 185 7e-46
AB030073-1|BAA89296.1| 819|Homo sapiens K-sam-IIH1 protein. 184 2e-45
AB030077-1|BAA89300.1| 817|Homo sapiens K-sam-IIO2 protein. 182 5e-45
X56191-1|CAA39654.1| 769|Homo sapiens fibroblast growth factor ... 182 7e-45
AJ243297-1|CAB46483.1| 1091|Homo sapiens RET tyrosine kinase rec... 182 7e-45
AF360695-4|AAK94208.1| 766|Homo sapiens keratinocyte growth fac... 182 7e-45
AF097353-2|AAD31561.1| 554|Homo sapiens fibroblast growth facto... 182 7e-45
AF097353-1|AAD31560.1| 555|Homo sapiens fibroblast growth recep... 182 7e-45
M35718-1|AAA36152.1| 682|Homo sapiens protein ( Human heparin-b... 181 2e-44
AB030078-1|BAA89301.1| 768|Homo sapiens K-sam-IIO3 protein. 179 6e-44
AB030076-1|BAA89299.1| 771|Homo sapiens K-sam-IIO1 protein. 179 6e-44
AB030075-1|BAA89298.1| 830|Homo sapiens K-sam-IIH3 protein. 179 6e-44
AB030074-1|BAA89297.1| 819|Homo sapiens K-sam-IIH2 protein. 179 6e-44
X54559-1|CAB56793.1| 1390|Homo sapiens proto-oncogene protein. 177 1e-43
U19348-1|AAA92686.1| 523|Homo sapiens tpr-met fusion protein pr... 176 3e-43
U08818-1|AAB60323.1| 455|Homo sapiens activated met oncogene pr... 176 3e-43
BC130420-1|AAI30421.1| 1390|Homo sapiens met proto-oncogene (hep... 176 3e-43
AB209898-1|BAD93135.1| 712|Homo sapiens met proto-oncogene prec... 176 3e-43
J02958-1|AAA59591.1| 1408|Homo sapiens MET protein. 175 8e-43
BC035514-1|AAH35514.2| 1124|Homo sapiens TEK tyrosine kinase, en... 169 5e-41
X57019-1|CAA40338.1| 894|Homo sapiens protein ( H.sapiens mRNA ... 166 4e-40
S65125-1|AAB20305.1| 894|Homo sapiens UFO protein. 166 4e-40
M76125-1|AAA61243.1| 885|Homo sapiens tyrosine kinase receptor ... 166 4e-40
L06139-1|AAA61139.1| 1124|Homo sapiens receptor protein-tyrosine... 166 5e-40
AL133411-1|CAI16055.1| 1124|Homo sapiens TEK tyrosine kinase, en... 166 5e-40
AB208796-1|BAD92033.1| 1157|Homo sapiens TEK tyrosine kinase var... 166 5e-40
BC032229-1|AAH32229.1| 894|Homo sapiens AXL receptor tyrosine k... 165 6e-40
X70040-1|CAA49634.1| 1400|Homo sapiens tyrosine kinase protein. 163 2e-39
X72886-1|CAA51396.1| 272|Homo sapiens TYRO3 protein. 160 3e-38
U18934-1|AAC50070.1| 882|Homo sapiens receptor tyrosine kinase ... 160 3e-38
U05682-1|AAA19236.1| 890|Homo sapiens Rse protein. 160 3e-38
D50479-1|BAA21781.1| 884|Homo sapiens protein-tyrosine kinase p... 160 3e-38
D17517-1|BAA04467.1| 890|Homo sapiens Sky protein. 160 3e-38
BC051756-1|AAH51756.1| 890|Homo sapiens TYRO3 protein tyrosine ... 160 3e-38
BC049368-1|AAH49368.1| 890|Homo sapiens TYRO3 protein tyrosine ... 160 3e-38
BC029925-1|AAH29925.2| 518|Homo sapiens TYRO3 protein protein. 160 3e-38
AB209431-1|BAD92668.1| 951|Homo sapiens TYRO3 protein tyrosine ... 160 3e-38
BC114918-1|AAI14919.1| 823|Homo sapiens MERTK protein protein. 158 1e-37
BC114917-1|AAI14918.1| 823|Homo sapiens MERTK protein protein. 158 1e-37
AF260529-1|AAG33129.1| 978|Homo sapiens MER receptor tyrosine k... 158 1e-37
AC093675-1|AAY24213.1| 567|Homo sapiens unknown protein. 158 1e-37
U08023-1|AAB60430.1| 999|Homo sapiens c-mer protein. 157 2e-37
BC109099-1|AAI09100.1| 773|Homo sapiens MUSK protein protein. 156 4e-37
BC109098-1|AAI09099.1| 783|Homo sapiens MUSK protein protein. 156 4e-37
AL513328-2|CAI17350.1| 867|Homo sapiens muscle, skeletal, recep... 156 4e-37
AL513328-1|CAI17349.1| 875|Homo sapiens muscle, skeletal, recep... 156 4e-37
AL157881-3|CAH69978.1| 867|Homo sapiens muscle, skeletal, recep... 156 4e-37
AL157881-2|CAH69977.1| 875|Homo sapiens muscle, skeletal, recep... 156 4e-37
AF006464-1|AAB63044.1| 869|Homo sapiens muscle specific tyrosin... 156 4e-37
L07868-1|AAB59446.1| 1308|Homo sapiens receptor tyrosine kinase ... 154 2e-36
BC112199-1|AAI12200.1| 1308|Homo sapiens v-erb-a erythroblastic ... 154 2e-36
AB209697-1|BAD92934.1| 892|Homo sapiens v-erb-a erythroblastic ... 154 2e-36
X00588-1|CAA25240.1| 1210|Homo sapiens epidermal growth factor r... 153 3e-36
L36162-1|AAA35487.1| 160|Homo sapiens receptor tyrosine kinase ... 153 3e-36
BC094761-1|AAH94761.1| 1091|Homo sapiens EGFR protein protein. 153 3e-36
AY588246-1|AAS83109.1| 1210|Homo sapiens epidermal growth factor... 153 3e-36
AY550966-1|AAT52212.1| 1210|Homo sapiens cell growth inhibiting ... 153 3e-36
AF288738-1|AAG35789.1| 1210|Homo sapiens p170 epidermal growth f... 153 3e-36
AB209442-1|BAD92679.1| 1081|Homo sapiens epidermal growth factor... 153 3e-36
X60957-1|CAA43290.1| 1138|Homo sapiens receptor tyrosine kinase ... 153 4e-36
BC038239-1|AAH38239.1| 1138|Homo sapiens tyrosine kinase with im... 153 4e-36
AL139289-10|CAI23385.1| 1138|Homo sapiens tyrosine kinase with i... 153 4e-36
AL139289-9|CAI23386.1| 541|Homo sapiens tyrosine kinase with im... 153 4e-36
AF217976-1|AAG17219.1| 421|Homo sapiens unknown protein. 153 4e-36
Z98880-3|CAI42375.1| 2341|Homo sapiens v-ros UR2 sarcoma virus o... 152 8e-36
Z98880-2|CAI42374.1| 2347|Homo sapiens v-ros UR2 sarcoma virus o... 152 8e-36
M13880-1|AAA36580.1| 494|Homo sapiens protein ( Human mcf3 (rea... 152 8e-36
M13599-1|AAA60277.1| 471|Homo sapiens ROS1 protein. 152 8e-36
AL132671-5|CAI23378.1| 2347|Homo sapiens v-ros UR2 sarcoma virus... 152 8e-36
AL132671-4|CAI23379.1| 2341|Homo sapiens v-ros UR2 sarcoma virus... 152 8e-36
X04434-1|CAA28030.1| 1367|Homo sapiens IGF-I receptor protein. 151 1e-35
M34353-1|AAA60278.1| 2347|Homo sapiens ROS1 protein. 151 1e-35
BC113612-1|AAI13613.1| 1367|Homo sapiens insulin-like growth fac... 151 1e-35
BC113610-1|AAI13611.1| 1367|Homo sapiens insulin-like growth fac... 151 1e-35
AY332722-1|AAP81165.1| 1367|Homo sapiens insulin-like growth fac... 151 1e-35
X02160-1|CAA26096.1| 1370|Homo sapiens protein ( Human mRNA for ... 150 2e-35
U02566-1|AAA17407.1| 723|Homo sapiens receptor tyrosine kinase ... 150 2e-35
M32972-1|AAA59452.1| 1382|Homo sapiens insulin receptor protein. 150 3e-35
M10051-1|AAA59174.1| 1382|Homo sapiens INSR protein. 150 3e-35
J05046-1|AAC31759.1| 1268|Homo sapiens insulin receptor-related ... 150 3e-35
BC117172-1|AAI17173.1| 1370|Homo sapiens insulin receptor protein. 150 3e-35
AL158169-3|CAH70009.1| 1297|Homo sapiens insulin receptor-relate... 150 3e-35
AB208861-1|BAD92098.1| 833|Homo sapiens insulin receptor varian... 150 3e-35
X96588-1|CAA65406.1| 577|Homo sapiens receptor tyrosine kinase ... 149 4e-35
BC021700-1|AAH21700.2| 395|Homo sapiens RYK protein protein. 149 4e-35
AB209405-1|BAD92642.1| 232|Homo sapiens RYK receptor-like tyros... 149 4e-35
X69970-1|CAA49591.1| 607|Homo sapiens h-ryk protein. 147 2e-34
X03363-1|CAA27060.1| 1255|Homo sapiens protein ( Human c-erb-B-2... 146 5e-34
M11767-1|AAA35808.1| 295|Homo sapiens protooncogene protein pro... 146 5e-34
M11730-1|AAA75493.1| 1255|Homo sapiens protein ( Human tyrosine ... 146 5e-34
AY208911-1|AAO18082.1| 1255|Homo sapiens v-erb-b2 erythroblastic... 146 5e-34
X06704-1|CAA29888.1| 439|Homo sapiens protein ( Human mRNA for ... 142 7e-33
X58741-1|CAA41565.2| 348|Homo sapiens tyrosine kinase protein. 142 9e-33
M16592-1|AAA52644.1| 505|Homo sapiens HCK protein. 142 9e-33
M16591-1|AAA52643.1| 505|Homo sapiens HCK protein. 142 9e-33
BC114463-1|AAI14464.2| 526|Homo sapiens hemopoietic cell kinase... 142 9e-33
BC108931-1|AAI08932.2| 526|Homo sapiens hemopoietic cell kinase... 142 9e-33
BC108930-1|AAI08931.2| 526|Homo sapiens hemopoietic cell kinase... 142 9e-33
BC094847-1|AAH94847.2| 526|Homo sapiens hemopoietic cell kinase... 142 9e-33
BC014435-1|AAH14435.2| 526|Homo sapiens hemopoietic cell kinase... 142 9e-33
AL353092-2|CAI19694.1| 505|Homo sapiens hemopoietic cell kinase... 142 9e-33
AL353092-1|CAI19695.1| 504|Homo sapiens hemopoietic cell kinase... 142 9e-33
AL121829-14|CAC15526.1| 488|Homo sapiens protein ( Human DNA se... 142 9e-33
AL049539-2|CAI22967.1| 504|Homo sapiens hemopoietic cell kinase... 142 9e-33
AL049539-1|CAI22966.1| 505|Homo sapiens hemopoietic cell kinase... 142 9e-33
AK026432-1|BAB15482.1| 505|Homo sapiens protein ( Homo sapiens ... 142 9e-33
U22322-1|AAC50116.1| 505|Homo sapiens Rak protein. 141 1e-32
U00803-1|AAA18284.1| 505|Homo sapiens SRC-like tyrosine kinase ... 141 1e-32
M35296-1|AAA35553.1| 1182|Homo sapiens protein ( Human tyrosine ... 141 1e-32
DQ009672-1|AAY16984.1| 1182|Homo sapiens v-abl Abelson murine le... 141 1e-32
BX538317-1|CAD98092.1| 1092|Homo sapiens hypothetical protein pr... 141 1e-32
BC065912-1|AAH65912.1| 1167|Homo sapiens ABL2 protein protein. 141 1e-32
BC012916-1|AAH12916.1| 505|Homo sapiens fyn-related kinase prot... 141 1e-32
AL512326-6|CAI13570.1| 1182|Homo sapiens v-abl Abelson murine le... 141 1e-32
AL512326-2|CAI13566.1| 1064|Homo sapiens v-abl Abelson murine le... 141 1e-32
AL359179-2|CAI15585.1| 1182|Homo sapiens v-abl Abelson murine le... 141 1e-32
AL359179-1|CAI15584.1| 1064|Homo sapiens v-abl Abelson murine le... 141 1e-32
AL357141-2|CAI16469.1| 505|Homo sapiens fyn-related kinase prot... 141 1e-32
AL139132-5|CAH70925.1| 1182|Homo sapiens v-abl Abelson murine le... 141 1e-32
AL139132-1|CAH70921.1| 1064|Homo sapiens v-abl Abelson murine le... 141 1e-32
AL121963-8|CAB87592.2| 505|Homo sapiens fyn-related kinase prot... 141 1e-32
X52213-1|CAA36460.1| 464|Homo sapiens ltk protein. 140 2e-32
BC113854-1|AAI13855.2| 504|Homo sapiens HCK protein protein. 140 2e-32
X85960-1|CAA59936.1| 591|Homo sapiens p68 TRK-T3 oncoprotein pr... 140 3e-32
X74765-1|CAB58562.1| 450|Homo sapiens protein tyrosine kinase p... 140 3e-32
X62947-1|CAA44719.1| 503|Homo sapiens 55 kd protein protein. 140 3e-32
X60702-1|CAA43113.1| 803|Homo sapiens tyrosine kinase protein. 140 3e-32
X60114-1|CAA42713.1| 450|Homo sapiens put. cytoplasmic tyrosine... 140 3e-32
X59932-1|CAA42556.1| 450|Homo sapiens c-src-kinase protein. 140 3e-32
S59184-1|AAB26341.1| 606|Homo sapiens RYK protein. 140 3e-32
M23102-1|AAA36770.1| 790|Homo sapiens protein ( Human trk proto... 140 3e-32
D16105-1|BAA03679.1| 864|Homo sapiens leukocyte tyrosine kinase... 140 3e-32
DQ075211-1|AAY57329.1| 450|Homo sapiens c-src tyrosine kinase p... 140 3e-32
CR541960-1|CAG46758.1| 450|Homo sapiens CSK protein. 140 3e-32
BC106073-1|AAI06074.1| 450|Homo sapiens c-src tyrosine kinase p... 140 3e-32
BC104875-1|AAI04876.1| 450|Homo sapiens c-src tyrosine kinase p... 140 3e-32
BC104847-1|AAI04848.1| 450|Homo sapiens c-src tyrosine kinase p... 140 3e-32
BC062580-1|AAH62580.1| 795|Homo sapiens NTRK1 protein protein. 140 3e-32
AL158169-4|CAH70010.1| 790|Homo sapiens neurotrophic tyrosine k... 140 3e-32
AB019488-1|BAA34355.1| 796|Homo sapiens TRKA protein. 140 3e-32
U12140-1|AAC51371.1| 822|Homo sapiens tyrosine kinase receptor ... 140 3e-32
U05012-1|AAA75374.1| 825|Homo sapiens TrkC protein. 140 3e-32
S76473-1|AAB33109.1| 822|Homo sapiens trkB protein. 140 3e-32
AL596132-4|CAH72315.1| 822|Homo sapiens neurotrophic tyrosine k... 140 3e-32
AL596132-3|CAH72316.1| 838|Homo sapiens neurotrophic tyrosine k... 140 3e-32
AL445532-2|CAH71817.1| 822|Homo sapiens neurotrophic tyrosine k... 140 3e-32
AL445532-1|CAH71816.1| 838|Homo sapiens neurotrophic tyrosine k... 140 3e-32
AL390777-4|CAH72196.1| 822|Homo sapiens neurotrophic tyrosine k... 140 3e-32
AL390777-3|CAH72195.1| 838|Homo sapiens neurotrophic tyrosine k... 140 3e-32
AK223626-1|BAD97346.1| 449|Homo sapiens c-src tyrosine kinase v... 140 3e-32
AF410899-1|AAL67965.1| 838|Homo sapiens neurotrophin receptor t... 140 3e-32
AF400441-1|AAK92490.1| 822|Homo sapiens neurotrophic tyrosine k... 140 3e-32
AF125808-1|AAF19762.1| 318|Homo sapiens ETS related protein-neu... 140 3e-32
AF041811-1|AAC12728.2| 408|Homo sapiens ETS related protein-gro... 140 3e-32
AC012069-1|AAY15092.1| 479|Homo sapiens unknown protein. 139 5e-32
X16416-1|CAA34438.1| 1130|Homo sapiens protein ( Human c-abl mRN... 138 8e-32
U07563-2|AAB60394.1| 1130|Homo sapiens proto-oncogene tyrosine-p... 138 8e-32
U07563-1|AAB60393.1| 1149|Homo sapiens proto-oncogene tyrosine-p... 138 8e-32
DQ145721-1|AAZ38718.1| 1149|Homo sapiens v-abl Abelson murine le... 138 8e-32
BC117451-1|AAI17452.1| 1149|Homo sapiens v-abl Abelson murine le... 138 8e-32
AL359092-11|CAM45752.1| 1149|Homo sapiens v-abl Abelson murine l... 138 8e-32
AL161733-3|CAM45756.1| 1149|Homo sapiens v-abl Abelson murine le... 138 8e-32
AL161733-1|CAM45754.1| 1130|Homo sapiens v-abl Abelson murine le... 138 8e-32
AB209642-1|BAD92879.1| 949|Homo sapiens Proto-oncogene tyrosine... 138 8e-32
AB209456-1|BAD92693.1| 1167|Homo sapiens v-abl Abelson murine le... 138 8e-32
L13738-1|AAA53570.2| 1036|Homo sapiens activated p21cdc42Hs kina... 138 1e-31
D29767-1|BAA06171.1| 631|Homo sapiens Tec protein-tyrosine kina... 138 1e-31
BC028164-1|AAH28164.1| 528|Homo sapiens TNK2 protein protein. 138 1e-31
AK131539-1|BAD18675.1| 1086|Homo sapiens protein ( Homo sapiens ... 138 1e-31
AB209338-1|BAD92575.1| 400|Homo sapiens Hypothetical protein FL... 138 1e-31
X03541-1|CAA27243.1| 641|Homo sapiens protein ( Human mRNA of t... 138 1e-31
BC101713-1|AAI01714.1| 631|Homo sapiens tec protein tyrosine ki... 138 1e-31
BC101711-1|AAI01712.1| 631|Homo sapiens tec protein tyrosine ki... 138 1e-31
M14752-1|AAA51561.1| 1130|Homo sapiens ABL1 protein. 137 2e-31
BC063414-1|AAH63414.1| 743|Homo sapiens PDGFRA protein protein. 137 2e-31
X77278-1|CAA54493.1| 507|Homo sapiens HYL tyrosine kinase protein. 137 2e-31
S75164-1|AAC60645.1| 507|Homo sapiens megakaryocyte-associated ... 137 2e-31
BC003109-1|AAH03109.1| 507|Homo sapiens megakaryocyte-associate... 137 2e-31
BC000114-1|AAH00114.1| 507|Homo sapiens megakaryocyte-associate... 137 2e-31
AC005777-1|AAC62843.1| 507|Homo sapiens MATK_HUMAN protein. 137 2e-31
S65186-1|AAB28072.2| 620|Homo sapiens EMT protein. 136 3e-31
M79321-1|AAB50019.1| 491|Homo sapiens Lyn B protein protein. 136 3e-31
M16038-1|AAA59540.1| 512|Homo sapiens LYN protein. 136 3e-31
L10717-1|AAA36748.1| 620|Homo sapiens tyrosine kinase protein. 136 3e-31
D13720-1|BAA02873.1| 620|Homo sapiens ITK protein. 136 3e-31
BC126458-1|AAI26459.1| 512|Homo sapiens LYN protein protein. 136 3e-31
BC126456-1|AAI26457.1| 512|Homo sapiens LYN protein protein. 136 3e-31
BC109078-1|AAI09079.1| 620|Homo sapiens IL2-inducible T-cell ki... 136 3e-31
BC109077-1|AAI09078.1| 620|Homo sapiens IL2-inducible T-cell ki... 136 3e-31
BC075002-1|AAH75002.1| 512|Homo sapiens v-yes-1 Yamaguchi sarco... 136 3e-31
BC075001-1|AAH75001.1| 512|Homo sapiens v-yes-1 Yamaguchi sarco... 136 3e-31
BC068551-1|AAH68551.1| 582|Homo sapiens LYN protein protein. 136 3e-31
BC059394-1|AAH59394.1| 582|Homo sapiens LYN protein protein. 136 3e-31
AC073324-1|AAS07524.1| 387|Homo sapiens unknown protein. 136 3e-31
AM051280-1|CAJ19686.1| 208|Homo sapiens dominant-negative kinas... 136 6e-31
X58957-1|CAA41728.1| 659|Homo sapiens agammaglobulinaemia tyros... 135 8e-31
U78027-4|AAB64205.1| 659|Homo sapiens Bruton's tyrosine kinase ... 135 8e-31
U13433-1|AAC51347.1| 657|Homo sapiens Bruton's agammaglobulinem... 135 8e-31
U10087-1|AAB60639.1| 659|Homo sapiens Bruton agammaglobulinemia... 135 8e-31
L31572-1|AAA61479.1| 659|Homo sapiens Bruton agammaglobulinemia... 135 8e-31
L13616-1|AAA58469.1| 1052|Homo sapiens focal adhesion kinase pro... 135 8e-31
L05186-1|AAA35819.1| 879|Homo sapiens focal adhesion kinase pro... 135 8e-31
BC109080-1|AAI09081.1| 659|Homo sapiens Bruton agammaglobulinem... 135 8e-31
BC109079-1|AAI09080.1| 659|Homo sapiens Bruton agammaglobulinem... 135 8e-31
BC035404-1|AAH35404.1| 1006|Homo sapiens PTK2 protein protein. 135 8e-31
BC028733-1|AAH28733.1| 680|Homo sapiens PTK2 protein protein. 135 8e-31
AL035422-3|CAB55876.1| 659|Homo sapiens Bruton agammaglobulinem... 135 8e-31
AK094999-1|BAC04470.1| 720|Homo sapiens protein ( Homo sapiens ... 135 8e-31
AF153764-1|AAF37341.1| 172|Homo sapiens Bruton's tyrosine kinas... 135 8e-31
AB209083-1|BAD92320.1| 1007|Homo sapiens PTK2 protein tyrosine k... 135 8e-31
AB209071-1|BAD92308.1| 975|Homo sapiens PTK2 protein tyrosine k... 135 8e-31
U66559-1|AAC51104.1| 1620|Homo sapiens anaplastic lymphoma kinas... 134 1e-30
U62540-1|AAB71619.1| 1620|Homo sapiens anaplastic lymphoma kinas... 134 1e-30
U04946-1|AAA58698.1| 680|Homo sapiens nucleophosmin-anaplastic ... 134 1e-30
D45915-1|BAA08343.1| 680|Homo sapiens p80 protein protein. 134 1e-30
AF390893-1|AAM17922.1| 803|Homo sapiens TRK-fused gene/anaplast... 134 1e-30
AF143407-1|AAF27292.1| 756|Homo sapiens TRK-fused gene/anaplast... 134 1e-30
AF125093-1|AAF42734.1| 701|Homo sapiens TRK-fused gene-anaplast... 134 1e-30
AC074096-1|AAY15027.1| 1192|Homo sapiens unknown protein. 134 1e-30
AB209477-1|BAD92714.1| 1626|Homo sapiens anaplastic lymphoma kin... 134 1e-30
AF153762-1|AAF37339.1| 174|Homo sapiens Bruton's tyrosine kinas... 134 2e-30
X14055-1|CAA32211.1| 509|Homo sapiens protein ( Human lymphocyt... 133 3e-30
X13529-1|CAA31884.1| 509|Homo sapiens protein ( Human lck mRNA ... 133 3e-30
X05027-1|CAA28691.1| 507|Homo sapiens protein ( Human T cell-sp... 133 3e-30
M36881-1|AAA59502.1| 509|Homo sapiens lymphocyte-specific prote... 133 3e-30
L27071-1|AAA74557.1| 527|Homo sapiens tyrosine kinase protein. 133 3e-30
BC013200-1|AAH13200.1| 539|Homo sapiens LCK protein protein. 133 3e-30
AL121991-3|CAI22321.1| 526|Homo sapiens lymphocyte-specific pro... 133 3e-30
AL121991-2|CAI22320.1| 496|Homo sapiens lymphocyte-specific pro... 133 3e-30
AJ865079-1|CAI23831.1| 516|Homo sapiens proto-oncogene tyrosine... 133 3e-30
AF228313-1|AAF34794.1| 496|Homo sapiens tyrosine kinase LCK pro... 133 3e-30
U34379-1|AAB60412.1| 527|Homo sapiens tyrosine kinase protein. 133 4e-30
U07236-1|AAA18225.1| 512|Homo sapiens lymphocyte-specific prote... 133 4e-30
AF153761-1|AAF37338.1| 174|Homo sapiens Bruton's tyrosine kinas... 133 4e-30
AF153758-1|AAF37335.1| 174|Homo sapiens Bruton's tyrosine kinas... 133 4e-30
AF153760-1|AAF37337.1| 174|Homo sapiens Bruton's tyrosine kinas... 132 5e-30
AF153759-1|AAF37336.1| 174|Homo sapiens Bruton's tyrosine kinas... 132 5e-30
AF153757-1|AAF37334.1| 174|Homo sapiens Bruton's tyrosine kinas... 132 5e-30
AF153756-1|AAF37333.1| 174|Homo sapiens Bruton's tyrosine kinas... 132 5e-30
U40271-1|AAC50484.2| 1070|Homo sapiens transmembrane receptor pr... 132 7e-30
BC130522-1|AAI30523.1| 943|Homo sapiens receptor tyrosine kinas... 132 7e-30
BC071557-1|AAH71557.1| 1070|Homo sapiens PTK7 protein tyrosine k... 132 7e-30
AL355385-4|CAI13783.1| 1070|Homo sapiens PTK7 protein tyrosine k... 132 7e-30
AL157486-1|CAB75674.1| 364|Homo sapiens hypothetical protein pr... 132 7e-30
AF531871-1|AAN04865.1| 1014|Homo sapiens transmembrane receptor ... 132 7e-30
AF531870-1|AAN04864.1| 940|Homo sapiens transmembrane receptor ... 132 7e-30
AF531869-1|AAN04863.1| 1030|Homo sapiens transmembrane receptor ... 132 7e-30
AF531868-1|AAN04862.1| 1070|Homo sapiens transmembrane receptor ... 132 7e-30
AF447176-1|AAL39062.1| 1070|Homo sapiens protein tyrosine kinase... 132 7e-30
AC092214-2|AAS07458.1| 976|Homo sapiens unknown protein. 132 7e-30
AB209154-1|BAD92391.1| 919|Homo sapiens Tyrosine-protein kinase... 132 7e-30
Z27409-1|CAA81796.1| 691|Homo sapiens receptor tyrosine kinase ... 132 9e-30
U38894-1|AAC50714.1| 388|Homo sapiens tyrosine kinase t-Ror1 pr... 132 9e-30
M97675-1|AAA60275.1| 937|Homo sapiens transmembrane receptor pr... 132 9e-30
M97639-1|AAA60276.1| 943|Homo sapiens transmembrane receptor pr... 132 9e-30
M18391-1|AAA36747.1| 984|Homo sapiens protein ( Human tyrosine ... 132 9e-30
BC130291-1|AAI30292.1| 976|Homo sapiens EPH receptor A1 protein. 132 9e-30
BC128386-1|AAI28387.1| 940|Homo sapiens ROR1 protein protein. 132 9e-30
AL928802-2|CAI17303.1| 943|Homo sapiens receptor tyrosine kinas... 132 9e-30
AL583841-2|CAI15694.1| 943|Homo sapiens receptor tyrosine kinas... 132 9e-30
AL445205-2|CAH71706.1| 937|Homo sapiens receptor tyrosine kinas... 132 9e-30
AL391219-1|CAH70208.1| 943|Homo sapiens receptor tyrosine kinas... 132 9e-30
AL161742-2|CAI21932.1| 937|Homo sapiens receptor tyrosine kinas... 132 9e-30
AL137859-2|CAI21732.1| 937|Homo sapiens receptor tyrosine kinas... 132 9e-30
AF294796-1|AAG01184.2| 910|Homo sapiens ROR2 protein protein. 132 9e-30
AF101171-1|AAD43440.1| 976|Homo sapiens receptor tyrosine kinas... 132 9e-30
X00663-1|CAA25282.1| 800|Homo sapiens protein ( Human mRNA frag... 131 1e-29
X83107-1|CAA58169.1| 675|Homo sapiens bmx protein. 131 2e-29
X52192-1|CAA36438.1| 822|Homo sapiens c-fes protein. 131 2e-29
BC016652-1|AAH16652.1| 675|Homo sapiens BMX non-receptor tyrosi... 131 2e-29
AY513657-1|AAS82869.1| 752|Homo sapiens proto-oncogene c-fes va... 131 2e-29
AY513656-1|AAS82868.1| 764|Homo sapiens proto-oncogene c-fes va... 131 2e-29
AY513654-1|AAS82866.1| 694|Homo sapiens proto-oncogene c-fes va... 131 2e-29
AF045459-1|AAC08966.1| 697|Homo sapiens Etk/Bmx cytosolic tyros... 131 2e-29
S71669-1|AAB30995.1| 465|Homo sapiens lsk protein. 130 3e-29
AL928802-1|CAI17302.1| 704|Homo sapiens receptor tyrosine kinas... 130 4e-29
AL591214-1|CAH71099.1| 704|Homo sapiens receptor tyrosine kinas... 130 4e-29
AL583841-1|CAI15693.1| 704|Homo sapiens receptor tyrosine kinas... 130 4e-29
X06292-1|CAA29619.1| 822|Homo sapiens NCP92 protein. 129 5e-29
M59371-1|AAA53375.1| 976|Homo sapiens protein-tyrosine kinase p... 129 5e-29
BC037166-1|AAH37166.1| 976|Homo sapiens EPH receptor A2 protein. 129 5e-29
BC035357-1|AAH35357.1| 822|Homo sapiens feline sarcoma oncogene... 129 5e-29
AL451042-1|CAH71943.1| 976|Homo sapiens EPH receptor A2 protein. 129 5e-29
J03358-1|AAA61190.1| 822|Homo sapiens FER protein. 128 9e-29
BC035782-1|AAH35782.1| 661|Homo sapiens TNK1 protein protein. 128 9e-29
AF097738-1|AAC99412.1| 661|Homo sapiens non-receptor tyosine ki... 128 9e-29
U43408-1|AAC50427.1| 666|Homo sapiens tyrosine kinase protein. 128 2e-28
AJ438313-1|CAD27356.1| 160|Homo sapiens KIT protein protein. 128 2e-28
Z33998-1|CAA83965.1| 505|Homo sapiens Protein-Tyrosine Kinase p... 127 3e-28
X02647-1|CAA26485.1| 351|Homo sapiens c-src protein. 127 3e-28
U43522-1|AAC05330.1| 1009|Homo sapiens cell adhesion kinase beta... 127 3e-28
U33635-1|AAA87565.1| 1070|Homo sapiens colon carcinoma kinase-4 ... 127 3e-28
U33284-1|AAC50203.1| 1009|Homo sapiens PYK2 protein. 127 3e-28
S80542-1|AAB35701.1| 1009|Homo sapiens related adhesion focal ty... 127 3e-28
L49207-1|AAB47217.1| 1009|Homo sapiens focal adhesion kinase pro... 127 3e-28
K03218-1|AAA60584.1| 536|Homo sapiens SRC protein. 127 3e-28
BC051270-1|AAH51270.2| 536|Homo sapiens v-src sarcoma (Schmidt-... 127 3e-28
BC042599-1|AAH42599.1| 1009|Homo sapiens PTK2B protein tyrosine ... 127 3e-28
BC036651-1|AAH36651.1| 1009|Homo sapiens PTK2B protein tyrosine ... 127 3e-28
BC032413-1|AAH32413.1| 505|Homo sapiens B lymphoid tyrosine kin... 127 3e-28
BC011566-1|AAH11566.1| 536|Homo sapiens SRC protein protein. 127 3e-28
BC007371-1|AAH07371.1| 505|Homo sapiens B lymphoid tyrosine kin... 127 3e-28
AL133293-2|CAC10573.1| 542|Homo sapiens v-src sarcoma (Schmidt-... 127 3e-28
AL133293-1|CAC34523.1| 536|Homo sapiens v-src sarcoma (Schmidt-... 127 3e-28
AK128371-1|BAC87404.1| 596|Homo sapiens protein ( Homo sapiens ... 127 3e-28
AK024281-1|BAB14871.1| 251|Homo sapiens protein ( Homo sapiens ... 127 3e-28
AB209085-1|BAD92322.1| 802|Homo sapiens PTK2B protein tyrosine ... 127 3e-28
AF153364-1|AAF61477.1| 149|Homo sapiens Bruton's tyrosine kinas... 126 3e-28
Z29093-1|CAA82335.1| 876|Homo sapiens receptor tyrosine kinase ... 126 5e-28
X74979-1|CAA52915.1| 876|Homo sapiens TrkE protein. 126 5e-28
S76617-1|AAB33265.1| 505|Homo sapiens blk protein. 126 5e-28
L57508-1|AAB05208.1| 876|Homo sapiens receptor kinase protein. 126 5e-28
L20817-1|AAA18019.1| 913|Homo sapiens tyrosine protein kinase p... 126 5e-28
BC070070-1|AAH70070.1| 876|Homo sapiens DDR1 protein protein. 126 5e-28
BC053878-1|AAH53878.1| 619|Homo sapiens zeta-chain (TCR) associ... 126 5e-28
BC039039-1|AAH39039.1| 493|Homo sapiens ZAP70 protein protein. 126 5e-28
BC013400-1|AAH13400.1| 876|Homo sapiens discoidin domain recept... 126 5e-28
BC008716-1|AAH08716.1| 876|Homo sapiens discoidin domain recept... 126 5e-28
BC008655-1|AAH08655.1| 253|Homo sapiens EPHA2 protein protein. 126 5e-28
BA000025-66|BAB63318.1| 913|Homo sapiens Receptor tyrosine kina... 126 5e-28
AY513655-1|AAS82867.1| 681|Homo sapiens proto-oncogene c-fes va... 126 5e-28
AL773589-2|CAI18534.1| 876|Homo sapiens discoidin domain recept... 126 5e-28
AL773589-1|CAI18533.1| 913|Homo sapiens discoidin domain recept... 126 5e-28
AL773541-2|CAI18450.1| 876|Homo sapiens discoidin domain recept... 126 5e-28
AL773541-1|CAI18451.1| 913|Homo sapiens discoidin domain recept... 126 5e-28
AL662870-9|CAM25688.1| 377|Homo sapiens discoidin domain recept... 126 5e-28
AL662870-7|CAI18442.1| 913|Homo sapiens discoidin domain recept... 126 5e-28
AL662870-6|CAI18441.1| 876|Homo sapiens discoidin domain recept... 126 5e-28
AL662854-9|CAM24839.1| 377|Homo sapiens discoidin domain recept... 126 5e-28
AL662854-7|CAI17433.1| 913|Homo sapiens discoidin domain recept... 126 5e-28
AL662854-6|CAI17434.1| 876|Homo sapiens discoidin domain recept... 126 5e-28
AC016699-1|AAX93187.1| 493|Homo sapiens unknown protein. 126 5e-28
AB210021-1|BAE06103.1| 894|Homo sapiens DDR1 variant protein pr... 126 5e-28
AB202100-1|BAE78621.1| 876|Homo sapiens discoidin domain recept... 126 5e-28
AB103608-1|BAF31270.1| 913|Homo sapiens DDR protein protein. 126 5e-28
AB088102-1|BAC54935.1| 913|Homo sapiens receptor tyrosine kinas... 126 5e-28
AB083211-1|BAC43747.1| 312|Homo sapiens truncated ZAP kinase pr... 126 5e-28
X95425-1|CAA64700.1| 1037|Homo sapiens EHK-1 receptor tyrosine k... 125 8e-28
M83941-1|AAA58633.1| 983|Homo sapiens receptor protein kinase p... 125 8e-28
L36644-1|AAA74245.1| 991|Homo sapiens receptor protein-tyrosine... 125 8e-28
BC063282-1|AAH63282.1| 983|Homo sapiens EPH receptor A3 protein. 125 8e-28
AF213459-1|AAG43576.1| 983|Homo sapiens ephrin receptor EPHA3 c... 125 8e-28
AB209375-1|BAD92612.1| 1017|Homo sapiens ephrin receptor EphA5 i... 125 8e-28
U48705-1|AAC50917.1| 913|Homo sapiens tyrosine kinase DDR protein. 125 1e-27
U07695-1|AAA20598.1| 987|Homo sapiens tyrosine kinase protein. 125 1e-27
L11315-1|AAA02866.1| 913|Homo sapiens receptor tyrosine kinase ... 125 1e-27
BC052804-1|AAH52804.1| 987|Homo sapiens EPH receptor B4 protein. 125 1e-27
BC004264-1|AAH04264.1| 845|Homo sapiens EPHB4 protein protein. 125 1e-27
AY056048-1|AAL14195.1| 935|Homo sapiens receptor protein tyrosi... 125 1e-27
AY056047-1|AAL14194.1| 987|Homo sapiens receptor protein tyrosi... 125 1e-27
AF312032-8|AAK21010.1| 987|Homo sapiens ephrin type-B receptor ... 125 1e-27
AB209644-1|BAD92881.1| 986|Homo sapiens ephrin receptor EphB4 p... 125 1e-27
Z29630-1|CAA82737.1| 612|Homo sapiens protein-tyrosine kinase p... 124 1e-27
X73568-1|CAA51970.1| 630|Homo sapiens protein tyrosin kinase pr... 124 1e-27
L28824-1|AAA36526.1| 635|Homo sapiens protein tyrosine kinase p... 124 1e-27
L18974-1|AAA16703.1| 527|Homo sapiens tyrosine kinase protein. 124 1e-27
BC011399-1|AAH11399.1| 612|Homo sapiens SYK protein protein. 124 1e-27
BC002962-1|AAH02962.1| 635|Homo sapiens spleen tyrosine kinase ... 124 1e-27
BC001645-1|AAH01645.1| 635|Homo sapiens spleen tyrosine kinase ... 124 1e-27
AL354862-3|CAI16875.1| 612|Homo sapiens spleen tyrosine kinase ... 124 1e-27
AL354862-2|CAI16876.1| 635|Homo sapiens spleen tyrosine kinase ... 124 1e-27
X78549-1|CAA55295.1| 451|Homo sapiens tyrosine kinase protein. 124 2e-27
U61412-1|AAC34935.1| 451|Homo sapiens non-receptor type protein... 124 2e-27
L36642-1|AAA74243.1| 998|Homo sapiens receptor protein-tyrosine... 124 2e-27
BC126151-1|AAI26152.1| 998|Homo sapiens EPH receptor A7 protein. 124 2e-27
BC126125-1|AAI26126.1| 998|Homo sapiens EPH receptor A7 protein. 124 2e-27
BC035843-1|AAH35843.1| 451|Homo sapiens PTK6 protein tyrosine k... 124 2e-27
AL591036-1|CAH73650.1| 998|Homo sapiens EPH receptor A7 protein. 124 2e-27
AL354857-1|CAH72780.1| 998|Homo sapiens EPH receptor A7 protein. 124 2e-27
AL121966-2|CAI19722.1| 998|Homo sapiens EPH receptor A7 protein. 124 2e-27
AL121829-13|CAC15525.1| 451|Homo sapiens Ptk6 protein. 124 2e-27
AB209269-1|BAD92506.1| 1000|Homo sapiens ephrin receptor EphA7 v... 124 2e-27
M14209-1|AAA52441.1| 211|Homo sapiens fes/fps proto-oncogene pr... 124 2e-27
L08961-1|AAC41766.1| 600|Homo sapiens tyrosine kinase protein. 124 2e-27
BC111744-1|AAI11745.1| 984|Homo sapiens EPH receptor B1 protein. 124 2e-27
Z97989-6|CAI22299.1| 485|Homo sapiens FYN oncogene related to S... 123 4e-27
Z97989-5|CAI22301.1| 534|Homo sapiens FYN oncogene related to S... 123 4e-27
Z97989-4|CAI22300.1| 537|Homo sapiens FYN oncogene related to S... 123 4e-27
M14333-1|AAC08285.1| 537|Homo sapiens protein ( Homo sapiens c-... 123 4e-27
BC032496-1|AAH32496.1| 482|Homo sapiens FYN oncogene related to... 123 4e-27
L40636-1|AAB08520.1| 984|Homo sapiens protein tyrosine kinase p... 122 6e-27
AL035703-1|CAB81612.1| 1005|Homo sapiens EPH receptor A8 protein. 122 6e-27
AB040892-1|BAA95983.1| 853|Homo sapiens KIAA1459 protein protein. 122 6e-27
BX537946-1|CAD97914.1| 969|Homo sapiens hypothetical protein pr... 122 7e-27
S74774-1|AAB33113.2| 534|Homo sapiens tyrosine kinase p59fyn(T)... 122 1e-26
M14676-1|AAA36615.1| 537|Homo sapiens protein ( Human src-like ... 122 1e-26
L36645-1|AAA74246.1| 986|Homo sapiens receptor protein-tyrosine... 122 1e-26
BC105002-1|AAI05003.1| 986|Homo sapiens ephrin receptor EphA4 p... 122 1e-26
BC105000-1|AAI05001.1| 986|Homo sapiens EPH receptor A4 protein. 122 1e-26
BC026327-1|AAH26327.1| 949|Homo sapiens EPHA4 protein protein. 122 1e-26
AC010899-2|AAY24284.1| 711|Homo sapiens unknown protein. 122 1e-26
M34309-1|AAA35979.1| 1342|Homo sapiens protein ( Human epidermal... 121 1e-26
M29366-1|AAA35790.1| 1342|Homo sapiens protein ( Human epidermal... 121 1e-26
BC082992-1|AAH82992.1| 1342|Homo sapiens v-erb-b2 erythroblastic... 121 1e-26
AF037332-1|AAD02031.1| 973|Homo sapiens Eph-like receptor tyros... 120 3e-26
X98208-1|CAA66871.1| 913|Homo sapiens discoidin receptor tyrosi... 119 5e-26
X74764-1|CAA52777.1| 855|Homo sapiens protein-tyrosine kinase p... 119 7e-26
M19722-1|AAA52451.1| 529|Homo sapiens FGR protein. 119 7e-26
BC064382-1|AAH64382.1| 529|Homo sapiens Gardner-Rasheed feline ... 119 7e-26
BC052998-1|AAH52998.1| 855|Homo sapiens discoidin domain recept... 119 7e-26
AL445197-3|CAI15941.1| 855|Homo sapiens discoidin domain recept... 119 7e-26
AL031729-3|CAB62998.1| 529|Homo sapiens Gardner-Rasheed feline ... 119 7e-26
>X51602-1|CAA35946.1| 1338|Homo sapiens protein ( Human flt mRNA for
receptor-related tyrosine kinase. ).
Length = 1338
Score = 343 bits (844), Expect = 2e-93
Identities = 207/573 (36%), Positives = 304/573 (53%), Gaps = 42/573 (7%)
Query: 451 SIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIY 510
S L C A GVP P I W+K++ I G L +ST IE + E+D G+Y
Sbjct: 677 STTLDCHANGVPEPQITWFKNNHKIQQEPGIILGPG-------SSTLFIERVTEEDEGVY 729
Query: 511 ECVALNNASELRRAYTLVLKAEKSYTPYXXXXXXXXXXXXGMVAYLFTWKLKKQRELTKA 570
C A N + + L ++ + + L T ++K + +
Sbjct: 730 HCKATNQKGSVESSAYLTVQGTSDKSNLELITLTCTCVAATLFWLLLTLLIRKMKRSSSE 789
Query: 571 GLLNFKSGNKKSFNPN-LGIDEQADLLPYD-EKFEFPREKLTFGKQLGAGAFGVVYKAEA 628
++ S +P+ + +DEQ + LPYD K+EF RE+L GK LG GAFG V +A A
Sbjct: 790 IKTDYLS---IIMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASA 846
Query: 629 RGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRE 688
GI + VAVKM+K A KAL +ELKI+ H+G H+N+VNLLGACTK
Sbjct: 847 FGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGP-- 904
Query: 689 LIVIVEYCKYGNIHNYMQKHREVFIDQLTDNAEKNLGKINKGFLNSVGTTGTHSDYFSSG 748
L+VIVEYCKYGN+ NY++ R++F +NK + +
Sbjct: 905 LMVIVEYCKYGNLSNYLKSKRDLFF-------------LNKDAALHMEPKKEKMEPGLEQ 951
Query: 749 NTKDTDHSLLYSGNSKRSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQ 808
K S+ S + SG + + E + +G Y P+T L+ ++FQ
Sbjct: 952 GKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFY------KEPITMEDLISYSFQ 1005
Query: 809 IARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKW 868
+ARGME+L++RK +H DLAARN+LL+++NVVKICDFGLAR +Y N +Y +K ++ LP+KW
Sbjct: 1006 VARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKW 1065
Query: 869 LAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS-PTDLLRWLSDGNRLEKPPFA 927
+A E + D+I+ST+SDVWSYG++LWE+FSL +PYP + D L +G R+ P ++
Sbjct: 1066 MAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYS 1125
Query: 928 DDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN---ERNRYVDLNAPYNEMNAELMT 984
+Y +ML CWH+ P RP F EL E LG+ L+ N + Y+ +NA + +
Sbjct: 1126 TPEIYQIMLDCWHRDPKERPRFAELVEKLGDLLQANVQQDGKDYIPINAILTGNSGFTYS 1185
Query: 985 ----GEDYL-AMVCAPDYNNIVTPSPNYVNMAK 1012
ED+ + AP +N+ + YVN K
Sbjct: 1186 TPAFSEDFFKESISAPKFNSGSSDDVRYVNAFK 1218
Score = 69.7 bits (163), Expect = 6e-11
Identities = 103/460 (22%), Positives = 181/460 (39%), Gaps = 57/460 (12%)
Query: 3 EIVVPRDCSKIVIECRPTTPDVNVTLSSEIPDYYYPSFR---YSPKIGFVPENSMPSDDQ 59
EI+ + ++VI CR T+P++ VTL D P + + + GF+ N+ +
Sbjct: 144 EIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKE-- 201
Query: 60 IISFVLCE-FVRGETRIEKYIYVSKHIKKPPKPKVAGGHK-QFLEGETFTIHC--RVPND 115
I + CE V G Y+ + +++ + L G T ++C P +
Sbjct: 202 -IGLLTCEATVNGHLYKTNYL-THRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLN 259
Query: 116 GLINFKWKYPPEVTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCG 175
+ W YP E N V ++ + +I Y +TI K G+YTC + +
Sbjct: 260 TRVQMTWSYPDE-KNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPS 318
Query: 176 EEKDEFRKIFLEKPFLSLRDLAKGKLMGNANK-SINIVIEIEAYPPVERTHFLKNDKYLP 234
+ +K F++++ + L A K S + ++++A+P E +LK+ LP
Sbjct: 319 FKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPE-VVWLKDG--LP 375
Query: 235 SNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKY--LTKNYTVDLRVFTKPE--A 290
+ + T L I D+ D NYT++ K + KN T L V KP+
Sbjct: 376 ATEKSARYLTRGY---SLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYE 432
Query: 291 KLLNNRIIKRLE--NSEMNFACKVTGYPLPDVTWIF---------------SNDEE---- 329
K +++ L S C G P P + W + SN+EE
Sbjct: 433 KAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFIL 492
Query: 330 -------HELSSTKSEQESLYAKTDYLKISVQA----SGVITCNAHNSKGEYFDSSTLLV 378
+ + S + K V A SG+ C A N G + + +
Sbjct: 493 DADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYI 552
Query: 379 YEINNGFGILQPLENWYSEKDSARKKCLASVYDYDNVSWL 418
++ NGF + LE +E + + C + + Y +V+W+
Sbjct: 553 TDVPNGFHV--NLEKMPTEGEDLKLSCTVNKFLYRDVTWI 590
Score = 41.9 bits (94), Expect = 0.013
Identities = 22/82 (26%), Positives = 34/82 (41%), Gaps = 4/82 (4%)
Query: 87 KPPKPKVAGGHKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVEVSVVKTEATTTG 146
K P+ + G G+T + CR G KW P V+ +S +S+ K+ G
Sbjct: 30 KDPELSLKGTQHIMQAGQTLHLQCR----GEAAHKWSLPEMVSKESERLSITKSACGRNG 85
Query: 147 SIVYQNITIRNATKKHNGVYTC 168
+T+ A H G Y+C
Sbjct: 86 KQFCSTLTLNTAQANHTGFYSC 107
Score = 37.1 bits (82), Expect = 0.37
Identities = 40/156 (25%), Positives = 64/156 (41%), Gaps = 8/156 (5%)
Query: 81 VSKHIKKPPKPKVAGGHKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVEVSVVKT 140
+S +I P K EGE + C V + W V N ++ S+ K
Sbjct: 548 ISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQ 607
Query: 141 E-ATTTGSIVYQNITIRNATKKHNGVYTCLLTNT-CGEEKDEFRKIFL---EKPFLSLRD 195
+ A T + N+TI N + + +G Y C N GEE + ++I + E P+L LR+
Sbjct: 608 KMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYL-LRN 666
Query: 196 LAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDK 231
L+ + + S + P + T F N K
Sbjct: 667 LSDHTVA--ISSSTTLDCHANGVPEPQITWFKNNHK 700
Score = 35.5 bits (78), Expect = 1.1
Identities = 30/122 (24%), Positives = 52/122 (42%), Gaps = 11/122 (9%)
Query: 252 LRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRLENSEMNFACK 311
L + D +++ I Y +A NK T + + P +N + E ++ +C
Sbjct: 522 LVVADSRISGI--YICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPT-EGEDLKLSCT 578
Query: 312 VTGYPLPDVTWIF----SNDEEH-ELSSTK---SEQESLYAKTDYLKISVQASGVITCNA 363
V + DVTWI +N H +S K +++ S+ + +S+Q SG C A
Sbjct: 579 VNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRA 638
Query: 364 HN 365
N
Sbjct: 639 RN 640
Score = 33.9 bits (74), Expect = 3.4
Identities = 31/131 (23%), Positives = 51/131 (38%), Gaps = 7/131 (5%)
Query: 252 LRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAK--LLNNRIIKRLE-NSEMNF 308
L I ++ L D Y A N Y + + + + LL N + +S
Sbjct: 621 LTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTL 680
Query: 309 ACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYL-KISVQASGVITCNAHNSK 367
C G P P +TW +N H++ + T ++ +++ + GV C A N K
Sbjct: 681 DCHANGVPEPQITWFKNN---HKIQQEPGIILGPGSSTLFIERVTEEDEGVYHCKATNQK 737
Query: 368 GEYFDSSTLLV 378
G S+ L V
Sbjct: 738 GSVESSAYLTV 748
>AL139005-1|CAI17096.1| 1338|Homo sapiens fms-related tyrosine kinase
1 (vascular endothelial growth factor/vascular perm
protein.
Length = 1338
Score = 343 bits (844), Expect = 2e-93
Identities = 211/576 (36%), Positives = 307/576 (53%), Gaps = 48/576 (8%)
Query: 451 SIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIY 510
S L C A GVP P I W+K++ I G L +ST IE + E+D G+Y
Sbjct: 677 STTLDCHANGVPEPQITWFKNNHKIQQEPGIILGPG-------SSTLFIERVTEEDEGVY 729
Query: 511 ECVALNNASELRRAYTLVLK--AEKSYTPYXXXXXX-XXXXXXGMVAYLFTWKLKKQREL 567
C A N + + L ++ ++KS ++ LF K+K+
Sbjct: 730 HCKATNQKGSVESSAYLTVQGTSDKSNLELITLTCTCVAATLFWLLLTLFIRKMKRSSSE 789
Query: 568 TKAGLLNFKSGNKKSFNPN-LGIDEQADLLPYD-EKFEFPREKLTFGKQLGAGAFGVVYK 625
K L+ +P+ + +DEQ + LPYD K+EF RE+L GK LG GAFG V +
Sbjct: 790 IKTDYLSI------IMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQ 843
Query: 626 AEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIA 685
A A GI + VAVKM+K A KAL +ELKI+ H+G H+N+VNLLGACTK
Sbjct: 844 ASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGG 903
Query: 686 KRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDNAEKNLGKINKGFLNSVGTTGTHSDYF 745
L+VIVEYCKYGN+ NY++ R++F +NK + +
Sbjct: 904 P--LMVIVEYCKYGNLSNYLKSKRDLFF-------------LNKDAALHMEPKKEKMEPG 948
Query: 746 SSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGW 805
K S+ S + SG + + E + +G Y P+T L+ +
Sbjct: 949 LEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFY------KEPITMEDLISY 1002
Query: 806 AFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLP 865
+FQ+ARGME+L++RK +H DLAARN+LL+++NVVKICDFGLAR +Y N +Y +K ++ LP
Sbjct: 1003 SFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLP 1062
Query: 866 VKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS-PTDLLRWLSDGNRLEKP 924
+KW+A E + D+I+ST+SDVWSYG++LWE+FSL +PYP + D L +G R+ P
Sbjct: 1063 LKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAP 1122
Query: 925 PFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN---ERNRYVDLNAPYNEMNAE 981
++ +Y +ML CWH+ P RP F EL E LG+ L+ N + Y+ +NA +
Sbjct: 1123 EYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLLQANVQQDGKDYIPINAILTGNSGF 1182
Query: 982 LMT----GEDYL-AMVCAPDYNNIVTPSPNYVNMAK 1012
+ ED+ + AP +N+ + YVN K
Sbjct: 1183 TYSTPAFSEDFFKESISAPKFNSGSSDDVRYVNAFK 1218
Score = 69.7 bits (163), Expect = 6e-11
Identities = 103/460 (22%), Positives = 181/460 (39%), Gaps = 57/460 (12%)
Query: 3 EIVVPRDCSKIVIECRPTTPDVNVTLSSEIPDYYYPSFR---YSPKIGFVPENSMPSDDQ 59
EI+ + ++VI CR T+P++ VTL D P + + + GF+ N+ +
Sbjct: 144 EIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKE-- 201
Query: 60 IISFVLCE-FVRGETRIEKYIYVSKHIKKPPKPKVAGGHK-QFLEGETFTIHC--RVPND 115
I + CE V G Y+ + +++ + L G T ++C P +
Sbjct: 202 -IGLLTCEATVNGHLYKTNYL-THRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLN 259
Query: 116 GLINFKWKYPPEVTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCG 175
+ W YP E N V ++ + +I Y +TI K G+YTC + +
Sbjct: 260 TRVQMTWSYPDE-KNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPS 318
Query: 176 EEKDEFRKIFLEKPFLSLRDLAKGKLMGNANK-SINIVIEIEAYPPVERTHFLKNDKYLP 234
+ +K F++++ + L A K S + ++++A+P E +LK+ LP
Sbjct: 319 FKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPE-VVWLKDG--LP 375
Query: 235 SNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKY--LTKNYTVDLRVFTKPE--A 290
+ + T L I D+ D NYT++ K + KN T L V KP+
Sbjct: 376 ATEKSARYLTRGY---SLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYE 432
Query: 291 KLLNNRIIKRLE--NSEMNFACKVTGYPLPDVTWIF---------------SNDEE---- 329
K +++ L S C G P P + W + SN+EE
Sbjct: 433 KAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFIL 492
Query: 330 -------HELSSTKSEQESLYAKTDYLKISVQA----SGVITCNAHNSKGEYFDSSTLLV 378
+ + S + K V A SG+ C A N G + + +
Sbjct: 493 DADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYI 552
Query: 379 YEINNGFGILQPLENWYSEKDSARKKCLASVYDYDNVSWL 418
++ NGF + LE +E + + C + + Y +V+W+
Sbjct: 553 TDVPNGFHV--NLEKMPTEGEDLKLSCTVNKFLYRDVTWI 590
Score = 41.9 bits (94), Expect = 0.013
Identities = 22/82 (26%), Positives = 34/82 (41%), Gaps = 4/82 (4%)
Query: 87 KPPKPKVAGGHKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVEVSVVKTEATTTG 146
K P+ + G G+T + CR G KW P V+ +S +S+ K+ G
Sbjct: 30 KDPELSLKGTQHIMQAGQTLHLQCR----GEAAHKWSLPEMVSKESERLSITKSACGRNG 85
Query: 147 SIVYQNITIRNATKKHNGVYTC 168
+T+ A H G Y+C
Sbjct: 86 KQFCSTLTLNTAQANHTGFYSC 107
Score = 37.1 bits (82), Expect = 0.37
Identities = 40/156 (25%), Positives = 64/156 (41%), Gaps = 8/156 (5%)
Query: 81 VSKHIKKPPKPKVAGGHKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVEVSVVKT 140
+S +I P K EGE + C V + W V N ++ S+ K
Sbjct: 548 ISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQ 607
Query: 141 E-ATTTGSIVYQNITIRNATKKHNGVYTCLLTNT-CGEEKDEFRKIFL---EKPFLSLRD 195
+ A T + N+TI N + + +G Y C N GEE + ++I + E P+L LR+
Sbjct: 608 KMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYL-LRN 666
Query: 196 LAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDK 231
L+ + + S + P + T F N K
Sbjct: 667 LSDHTVA--ISSSTTLDCHANGVPEPQITWFKNNHK 700
Score = 35.5 bits (78), Expect = 1.1
Identities = 30/122 (24%), Positives = 52/122 (42%), Gaps = 11/122 (9%)
Query: 252 LRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRLENSEMNFACK 311
L + D +++ I Y +A NK T + + P +N + E ++ +C
Sbjct: 522 LVVADSRISGI--YICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPT-EGEDLKLSCT 578
Query: 312 VTGYPLPDVTWIF----SNDEEH-ELSSTK---SEQESLYAKTDYLKISVQASGVITCNA 363
V + DVTWI +N H +S K +++ S+ + +S+Q SG C A
Sbjct: 579 VNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRA 638
Query: 364 HN 365
N
Sbjct: 639 RN 640
Score = 33.9 bits (74), Expect = 3.4
Identities = 31/131 (23%), Positives = 51/131 (38%), Gaps = 7/131 (5%)
Query: 252 LRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAK--LLNNRIIKRLE-NSEMNF 308
L I ++ L D Y A N Y + + + + LL N + +S
Sbjct: 621 LTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTL 680
Query: 309 ACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYL-KISVQASGVITCNAHNSK 367
C G P P +TW +N H++ + T ++ +++ + GV C A N K
Sbjct: 681 DCHANGVPEPQITWFKNN---HKIQQEPGIILGPGSSTLFIERVTEEDEGVYHCKATNQK 737
Query: 368 GEYFDSSTLLV 378
G S+ L V
Sbjct: 738 GSVESSAYLTV 748
>AL138712-1|CAI14846.1| 1338|Homo sapiens fms-related tyrosine kinase
1 (vascular endothelial growth factor/vascular perm
protein.
Length = 1338
Score = 343 bits (844), Expect = 2e-93
Identities = 211/576 (36%), Positives = 307/576 (53%), Gaps = 48/576 (8%)
Query: 451 SIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIY 510
S L C A GVP P I W+K++ I G L +ST IE + E+D G+Y
Sbjct: 677 STTLDCHANGVPEPQITWFKNNHKIQQEPGIILGPG-------SSTLFIERVTEEDEGVY 729
Query: 511 ECVALNNASELRRAYTLVLK--AEKSYTPYXXXXXX-XXXXXXGMVAYLFTWKLKKQREL 567
C A N + + L ++ ++KS ++ LF K+K+
Sbjct: 730 HCKATNQKGSVESSAYLTVQGTSDKSNLELITLTCTCVAATLFWLLLTLFIRKMKRSSSE 789
Query: 568 TKAGLLNFKSGNKKSFNPN-LGIDEQADLLPYD-EKFEFPREKLTFGKQLGAGAFGVVYK 625
K L+ +P+ + +DEQ + LPYD K+EF RE+L GK LG GAFG V +
Sbjct: 790 IKTDYLSI------IMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQ 843
Query: 626 AEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIA 685
A A GI + VAVKM+K A KAL +ELKI+ H+G H+N+VNLLGACTK
Sbjct: 844 ASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGG 903
Query: 686 KRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDNAEKNLGKINKGFLNSVGTTGTHSDYF 745
L+VIVEYCKYGN+ NY++ R++F +NK + +
Sbjct: 904 P--LMVIVEYCKYGNLSNYLKSKRDLFF-------------LNKDAALHMEPKKEKMEPG 948
Query: 746 SSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGW 805
K S+ S + SG + + E + +G Y P+T L+ +
Sbjct: 949 LEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFY------KEPITMEDLISY 1002
Query: 806 AFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLP 865
+FQ+ARGME+L++RK +H DLAARN+LL+++NVVKICDFGLAR +Y N +Y +K ++ LP
Sbjct: 1003 SFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLP 1062
Query: 866 VKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS-PTDLLRWLSDGNRLEKP 924
+KW+A E + D+I+ST+SDVWSYG++LWE+FSL +PYP + D L +G R+ P
Sbjct: 1063 LKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAP 1122
Query: 925 PFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN---ERNRYVDLNAPYNEMNAE 981
++ +Y +ML CWH+ P RP F EL E LG+ L+ N + Y+ +NA +
Sbjct: 1123 EYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLLQANVQQDGKDYIPINAILTGNSGF 1182
Query: 982 LMT----GEDYL-AMVCAPDYNNIVTPSPNYVNMAK 1012
+ ED+ + AP +N+ + YVN K
Sbjct: 1183 TYSTPAFSEDFFKESISAPKFNSGSSDDVRYVNAFK 1218
Score = 69.7 bits (163), Expect = 6e-11
Identities = 103/460 (22%), Positives = 181/460 (39%), Gaps = 57/460 (12%)
Query: 3 EIVVPRDCSKIVIECRPTTPDVNVTLSSEIPDYYYPSFR---YSPKIGFVPENSMPSDDQ 59
EI+ + ++VI CR T+P++ VTL D P + + + GF+ N+ +
Sbjct: 144 EIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKE-- 201
Query: 60 IISFVLCE-FVRGETRIEKYIYVSKHIKKPPKPKVAGGHK-QFLEGETFTIHC--RVPND 115
I + CE V G Y+ + +++ + L G T ++C P +
Sbjct: 202 -IGLLTCEATVNGHLYKTNYL-THRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLN 259
Query: 116 GLINFKWKYPPEVTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCG 175
+ W YP E N V ++ + +I Y +TI K G+YTC + +
Sbjct: 260 TRVQMTWSYPDE-KNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPS 318
Query: 176 EEKDEFRKIFLEKPFLSLRDLAKGKLMGNANK-SINIVIEIEAYPPVERTHFLKNDKYLP 234
+ +K F++++ + L A K S + ++++A+P E +LK+ LP
Sbjct: 319 FKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPE-VVWLKDG--LP 375
Query: 235 SNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKY--LTKNYTVDLRVFTKPE--A 290
+ + T L I D+ D NYT++ K + KN T L V KP+
Sbjct: 376 ATEKSARYLTRGY---SLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYE 432
Query: 291 KLLNNRIIKRLE--NSEMNFACKVTGYPLPDVTWIF---------------SNDEE---- 329
K +++ L S C G P P + W + SN+EE
Sbjct: 433 KAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFIL 492
Query: 330 -------HELSSTKSEQESLYAKTDYLKISVQA----SGVITCNAHNSKGEYFDSSTLLV 378
+ + S + K V A SG+ C A N G + + +
Sbjct: 493 DADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYI 552
Query: 379 YEINNGFGILQPLENWYSEKDSARKKCLASVYDYDNVSWL 418
++ NGF + LE +E + + C + + Y +V+W+
Sbjct: 553 TDVPNGFHV--NLEKMPTEGEDLKLSCTVNKFLYRDVTWI 590
Score = 41.9 bits (94), Expect = 0.013
Identities = 22/82 (26%), Positives = 34/82 (41%), Gaps = 4/82 (4%)
Query: 87 KPPKPKVAGGHKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVEVSVVKTEATTTG 146
K P+ + G G+T + CR G KW P V+ +S +S+ K+ G
Sbjct: 30 KDPELSLKGTQHIMQAGQTLHLQCR----GEAAHKWSLPEMVSKESERLSITKSACGRNG 85
Query: 147 SIVYQNITIRNATKKHNGVYTC 168
+T+ A H G Y+C
Sbjct: 86 KQFCSTLTLNTAQANHTGFYSC 107
Score = 37.1 bits (82), Expect = 0.37
Identities = 40/156 (25%), Positives = 64/156 (41%), Gaps = 8/156 (5%)
Query: 81 VSKHIKKPPKPKVAGGHKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVEVSVVKT 140
+S +I P K EGE + C V + W V N ++ S+ K
Sbjct: 548 ISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQ 607
Query: 141 E-ATTTGSIVYQNITIRNATKKHNGVYTCLLTNT-CGEEKDEFRKIFL---EKPFLSLRD 195
+ A T + N+TI N + + +G Y C N GEE + ++I + E P+L LR+
Sbjct: 608 KMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYL-LRN 666
Query: 196 LAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDK 231
L+ + + S + P + T F N K
Sbjct: 667 LSDHTVA--ISSSTTLDCHANGVPEPQITWFKNNHK 700
Score = 35.5 bits (78), Expect = 1.1
Identities = 30/122 (24%), Positives = 52/122 (42%), Gaps = 11/122 (9%)
Query: 252 LRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRLENSEMNFACK 311
L + D +++ I Y +A NK T + + P +N + E ++ +C
Sbjct: 522 LVVADSRISGI--YICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPT-EGEDLKLSCT 578
Query: 312 VTGYPLPDVTWIF----SNDEEH-ELSSTK---SEQESLYAKTDYLKISVQASGVITCNA 363
V + DVTWI +N H +S K +++ S+ + +S+Q SG C A
Sbjct: 579 VNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRA 638
Query: 364 HN 365
N
Sbjct: 639 RN 640
Score = 33.9 bits (74), Expect = 3.4
Identities = 31/131 (23%), Positives = 51/131 (38%), Gaps = 7/131 (5%)
Query: 252 LRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAK--LLNNRIIKRLE-NSEMNF 308
L I ++ L D Y A N Y + + + + LL N + +S
Sbjct: 621 LTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTL 680
Query: 309 ACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYL-KISVQASGVITCNAHNSK 367
C G P P +TW +N H++ + T ++ +++ + GV C A N K
Sbjct: 681 DCHANGVPEPQITWFKNN---HKIQQEPGIILGPGSSTLFIERVTEEDEGVYHCKATNQK 737
Query: 368 GEYFDSSTLLV 378
G S+ L V
Sbjct: 738 GSVESSAYLTV 748
>AF063657-1|AAC16449.2| 1338|Homo sapiens vascular endothelial growth
factor receptor protein.
Length = 1338
Score = 343 bits (844), Expect = 2e-93
Identities = 211/576 (36%), Positives = 307/576 (53%), Gaps = 48/576 (8%)
Query: 451 SIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIY 510
S L C A GVP P I W+K++ I G L +ST IE + E+D G+Y
Sbjct: 677 STTLDCHANGVPEPQITWFKNNHKIQQEPGIILGPG-------SSTLFIERVTEEDEGVY 729
Query: 511 ECVALNNASELRRAYTLVLK--AEKSYTPYXXXXXX-XXXXXXGMVAYLFTWKLKKQREL 567
C A N + + L ++ ++KS ++ LF K+K+
Sbjct: 730 HCKATNQKGSVESSAYLTVQGTSDKSNLELITLTCTCVAATLFWLLLTLFIRKMKRSSSE 789
Query: 568 TKAGLLNFKSGNKKSFNPN-LGIDEQADLLPYD-EKFEFPREKLTFGKQLGAGAFGVVYK 625
K L+ +P+ + +DEQ + LPYD K+EF RE+L GK LG GAFG V +
Sbjct: 790 IKTDYLSI------IMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQ 843
Query: 626 AEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIA 685
A A GI + VAVKM+K A KAL +ELKI+ H+G H+N+VNLLGACTK
Sbjct: 844 ASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGG 903
Query: 686 KRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDNAEKNLGKINKGFLNSVGTTGTHSDYF 745
L+VIVEYCKYGN+ NY++ R++F +NK + +
Sbjct: 904 P--LMVIVEYCKYGNLSNYLKSKRDLFF-------------LNKDAALHMEPKKEKMEPG 948
Query: 746 SSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGW 805
K S+ S + SG + + E + +G Y P+T L+ +
Sbjct: 949 LEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFY------KEPITMEDLISY 1002
Query: 806 AFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLP 865
+FQ+ARGME+L++RK +H DLAARN+LL+++NVVKICDFGLAR +Y N +Y +K ++ LP
Sbjct: 1003 SFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLP 1062
Query: 866 VKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS-PTDLLRWLSDGNRLEKP 924
+KW+A E + D+I+ST+SDVWSYG++LWE+FSL +PYP + D L +G R+ P
Sbjct: 1063 LKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAP 1122
Query: 925 PFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN---ERNRYVDLNAPYNEMNAE 981
++ +Y +ML CWH+ P RP F EL E LG+ L+ N + Y+ +NA +
Sbjct: 1123 EYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLLQANVQQDGKDYIPINAILTGNSGF 1182
Query: 982 LMT----GEDYL-AMVCAPDYNNIVTPSPNYVNMAK 1012
+ ED+ + AP +N+ + YVN K
Sbjct: 1183 TYSTPAFSEDFFKESISAPKFNSGSSDDVRYVNAFK 1218
Score = 70.1 bits (164), Expect = 4e-11
Identities = 102/460 (22%), Positives = 183/460 (39%), Gaps = 57/460 (12%)
Query: 3 EIVVPRDCSKIVIECRPTTPDVNVTLSSEIPDYYYPSFR---YSPKIGFVPENSMPSDDQ 59
EI+ + ++VI CR T+P++ VTL D P + + + GF+ N+ +
Sbjct: 144 EIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKE-- 201
Query: 60 IISFVLCE-FVRGETRIEKYIYVSKHIKKPPKPKVAGGHK-QFLEGETFTIHC--RVPND 115
I + CE V G Y+ + +++ + L G T ++C P +
Sbjct: 202 -IGLLTCEATVNGHLYKTNYL-THRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLN 259
Query: 116 GLINFKWKYPPEVTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCG 175
+ W YP E N V ++ + +I Y +TI K G+YTC + +
Sbjct: 260 TRVQMTWSYPDE-KNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPS 318
Query: 176 EEKDEFRKIFLEKPFLSLRDLAKGKLMGNANK-SINIVIEIEAYPPVERTHFLKNDKYLP 234
+ +K F++++ + L A K S + ++++A+P E +LK+ LP
Sbjct: 319 FKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPE-VVWLKDG--LP 375
Query: 235 SNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKY--LTKNYTVDLRVFTKPE--A 290
+ + T L I D+ D NYT++ K + KN T L V KP+
Sbjct: 376 ATEKSARYLTRGY---SLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYE 432
Query: 291 KLLNNRIIKRLE--NSEMNFACKVTGYPLPDVTWIF---------------SNDEEHELS 333
K +++ L S C G P P + W + SN+EE +
Sbjct: 433 KAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESSIL 492
Query: 334 STKSEQ----ESLYAKTDYLK-----------ISVQASGVITCNAHNSKGEYFDSSTLLV 378
S ES+ + ++ + SG+ C A N G + + +
Sbjct: 493 DADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYI 552
Query: 379 YEINNGFGILQPLENWYSEKDSARKKCLASVYDYDNVSWL 418
++ NGF + LE +E + + C + + Y +V+W+
Sbjct: 553 TDVPNGFHV--NLEKMPTEGEDLKLSCTVNKFLYRDVTWI 590
Score = 41.9 bits (94), Expect = 0.013
Identities = 22/82 (26%), Positives = 34/82 (41%), Gaps = 4/82 (4%)
Query: 87 KPPKPKVAGGHKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVEVSVVKTEATTTG 146
K P+ + G G+T + CR G KW P V+ +S +S+ K+ G
Sbjct: 30 KDPELSLKGTQHIMQAGQTLHLQCR----GEAAHKWSLPEMVSKESERLSITKSACGRNG 85
Query: 147 SIVYQNITIRNATKKHNGVYTC 168
+T+ A H G Y+C
Sbjct: 86 KQFCSTLTLNTAQANHTGFYSC 107
Score = 37.1 bits (82), Expect = 0.37
Identities = 40/156 (25%), Positives = 64/156 (41%), Gaps = 8/156 (5%)
Query: 81 VSKHIKKPPKPKVAGGHKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVEVSVVKT 140
+S +I P K EGE + C V + W V N ++ S+ K
Sbjct: 548 ISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQ 607
Query: 141 E-ATTTGSIVYQNITIRNATKKHNGVYTCLLTNT-CGEEKDEFRKIFL---EKPFLSLRD 195
+ A T + N+TI N + + +G Y C N GEE + ++I + E P+L LR+
Sbjct: 608 KMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYL-LRN 666
Query: 196 LAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDK 231
L+ + + S + P + T F N K
Sbjct: 667 LSDHTVA--ISSSTTLDCHANGVPEPQITWFKNNHK 700
Score = 35.5 bits (78), Expect = 1.1
Identities = 30/122 (24%), Positives = 52/122 (42%), Gaps = 11/122 (9%)
Query: 252 LRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRLENSEMNFACK 311
L + D +++ I Y +A NK T + + P +N + E ++ +C
Sbjct: 522 LVVADSRISGI--YICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPT-EGEDLKLSCT 578
Query: 312 VTGYPLPDVTWIF----SNDEEH-ELSSTK---SEQESLYAKTDYLKISVQASGVITCNA 363
V + DVTWI +N H +S K +++ S+ + +S+Q SG C A
Sbjct: 579 VNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRA 638
Query: 364 HN 365
N
Sbjct: 639 RN 640
Score = 33.9 bits (74), Expect = 3.4
Identities = 31/131 (23%), Positives = 51/131 (38%), Gaps = 7/131 (5%)
Query: 252 LRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAK--LLNNRIIKRLE-NSEMNF 308
L I ++ L D Y A N Y + + + + LL N + +S
Sbjct: 621 LTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTL 680
Query: 309 ACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYL-KISVQASGVITCNAHNSK 367
C G P P +TW +N H++ + T ++ +++ + GV C A N K
Sbjct: 681 DCHANGVPEPQITWFKNN---HKIQQEPGIILGPGSSTLFIERVTEEDEGVYHCKATNQK 737
Query: 368 GEYFDSSTLLV 378
G S+ L V
Sbjct: 738 GSVESSAYLTV 748
>BC131822-1|AAI31823.1| 1356|Homo sapiens kinase insert domain
receptor (a type III receptor tyrosine kinase) protein.
Length = 1356
Score = 337 bits (828), Expect = 1e-91
Identities = 280/980 (28%), Positives = 449/980 (45%), Gaps = 81/980 (8%)
Query: 12 KIVIECRPTTPDVNVTLSSEIPDYYYPSFRYSPKIGFVPENSMPSDDQIISFVLCEFVRG 71
K+V+ C T ++NV + ++ YPS ++ K + S ++ F+ + G
Sbjct: 241 KLVLNCTART-ELNVGIDF---NWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDG 296
Query: 72 ETRIEKYIYV------------SKHIKKPPKPKVA-GGHKQFLEGETFTIHCRVPNDGLI 118
TR ++ +Y S ++ KP VA G + L T R+P
Sbjct: 297 ITRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIP----A 352
Query: 119 NFKWKYPPEVTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEK 178
+ PPE+ + + G + +TI +++ G YT +LTN +EK
Sbjct: 353 KYLGYPPPEIKWYKNGIPLESNHTIKAGHV----LTIMEVSERDTGNYTVILTNPISKEK 408
Query: 179 DEF--RKIFLEKPFLSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDKYLPSN 236
+ P + + L + + + A PP H+ + +N
Sbjct: 409 QSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECAN 468
Query: 237 DLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLT---KNYTVDLRVFTKPEAKLL 293
+ + V+ + N P ++ N V +N++ KN TV V L
Sbjct: 469 EPSHAVS-VTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSAL 527
Query: 294 NN-RIIKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYLKIS 352
+ ++ E + VT P + E+ +S + S + + K+
Sbjct: 528 YKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLG 587
Query: 353 VQASGVITCNAHNSKGEYFDSSTLL---VYEINNGFGILQPLENWYSEKDSARKKCLASV 409
Q + + D+ L ++ + ++ L+N S +D CLA
Sbjct: 588 PQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKN-ASLQDQGDYVCLAQD 646
Query: 410 YDYDNVSWLGSDGNILDDIELLAPIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWY 469
+ +L E +AP I N+ G SI++ C A G P P I W+
Sbjct: 647 RKTKKRHCVVRQLTVL---ERVAPTITGNLENQTTSI--GESIEVSCTASGNPPPQIMWF 701
Query: 470 KDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIYECVALNNASELRRAYTLVL 529
KD+E + +SG L N I ++++D G+Y C A + + ++
Sbjct: 702 KDNETLVEDSGIVLKDG-------NRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFII 754
Query: 530 KAEKSYTPYXXXXXXXXXXXXGMVAYLFTWKLKK--QRELTKAGLLNFKSGNKKS-FNPN 586
+ + T V +F W L R + +A K+G +P+
Sbjct: 755 EGAQEKTNLEIIILVGTA-----VIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPD 809
Query: 587 -LGIDEQADLLPYD-EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKM 644
L +DE + LPYD K+EFPR++L GK LG GAFG V +A+A GI VAVKM
Sbjct: 810 ELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKM 869
Query: 645 VKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNY 704
+K A + +AL SELKI++H+G H+N+VNLLGACTK L+VIVE+CK+GN+ Y
Sbjct: 870 LKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTK--PGGPLMVIVEFCKFGNLSTY 927
Query: 705 MQKHREVFIDQLTDNAEKNLGKINKGFLNSVGTTGTHSDYFSSGNTKDTDHSLLYSGNSK 764
++ R F+ T A GK DY + D L +S+
Sbjct: 928 LRSKRNEFVPYKTKGARFRQGK----------------DYVGAIPV-DLKRRLDSITSSQ 970
Query: 765 RSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHG 824
S S G+++++ + E + E LT HL+ ++FQ+A+GME+LA+RK +H
Sbjct: 971 SSA---SSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHR 1027
Query: 825 DLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSD 884
DLAARN+LL++ NVVKICDFGLAR +Y + +Y +K ++ LP+KW+A E + DR+++ QSD
Sbjct: 1028 DLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSD 1087
Query: 885 VWSYGIVLWEMFSLAKTPYPNIS-PTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKP 943
VWS+G++LWE+FSL +PYP + + R L +G R+ P + +Y ML CWH +P
Sbjct: 1088 VWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEP 1147
Query: 944 TARPSFTELQEILGNFLEDN 963
+ RP+F+EL E LGN L+ N
Sbjct: 1148 SQRPTFSELVEHLGNLLQAN 1167
Score = 57.2 bits (132), Expect = 3e-07
Identities = 76/331 (22%), Positives = 132/331 (39%), Gaps = 25/331 (7%)
Query: 13 IVIECRPTTPDVNVTLSSEIPDY-YYPS---FRYSPKIGFVPENSMPSDDQIISFVLCEF 68
+VI C + ++NV+L + P+ + P + K GF + M S V CE
Sbjct: 146 VVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMIS---YAGMVFCEA 202
Query: 69 VRGETRIEKYIYVSKHIKKPPKPKVAG-GHKQFLE-GETFTIHC--RVPNDGLINFKWKY 124
+ + +Y+ + V H L GE ++C R + I+F W+Y
Sbjct: 203 KINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEY 262
Query: 125 PPEVTNDSVEVSV-VKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEKDEFRK 183
P V+ +KT++ + +TI T+ G+YTC ++ +K+
Sbjct: 263 PSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGITRSDQGLYTCAASSGLMTKKNSTFV 322
Query: 184 IFLEKPFLSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDKYLPSNDLKYNVT 243
EKPF++ + + + + I + YPP E + KN L SN
Sbjct: 323 RVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPE-IKWYKNGIPLESNH------ 375
Query: 244 TLANGDPKLRINDLKLTDIANYTLVAENKYL--TKNYTVDLRVFTKPE--AKLLNNRIIK 299
T+ G L I ++ D NYT++ N +++ V L V+ P+ K L + +
Sbjct: 376 TIKAGH-VLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDS 434
Query: 300 RLENSEMNFACKVTGYPLP-DVTWIFSNDEE 329
+ C V P P + W + +EE
Sbjct: 435 YQYGTTQTLTCTVYAIPPPHHIHWYWQLEEE 465
>AF063658-1|AAC16450.1| 1356|Homo sapiens vascular endothelial growth
factor receptor 2 protein.
Length = 1356
Score = 336 bits (826), Expect = 3e-91
Identities = 280/980 (28%), Positives = 448/980 (45%), Gaps = 81/980 (8%)
Query: 12 KIVIECRPTTPDVNVTLSSEIPDYYYPSFRYSPKIGFVPENSMPSDDQIISFVLCEFVRG 71
K+V+ C T ++NV + ++ YPS ++ K + S ++ F+ + G
Sbjct: 241 KLVLNCTART-ELNVGIDF---NWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDG 296
Query: 72 ETRIEKYIYV------------SKHIKKPPKPKVA-GGHKQFLEGETFTIHCRVPNDGLI 118
TR ++ +Y S ++ KP VA G + L T R+P
Sbjct: 297 VTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIP----A 352
Query: 119 NFKWKYPPEVTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEK 178
+ PPE+ + + G + +TI +++ G YT +LTN +EK
Sbjct: 353 KYLGYPPPEIKWYKNGIPLESNHTIKAGHV----LTIMEVSERDTGNYTVILTNPISKEK 408
Query: 179 DEF--RKIFLEKPFLSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDKYLPSN 236
+ P + + L + + + A PP H+ + +N
Sbjct: 409 QSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECAN 468
Query: 237 DLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLT---KNYTVDLRVFTKPEAKLL 293
+ V+ + N P ++ N V +N++ KN TV V L
Sbjct: 469 EPSQAVS-VTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSAL 527
Query: 294 NN-RIIKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYLKIS 352
+ ++ E + VT P + E+ +S + S + + K+
Sbjct: 528 YKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLG 587
Query: 353 VQASGVITCNAHNSKGEYFDSSTLL---VYEINNGFGILQPLENWYSEKDSARKKCLASV 409
Q + + D+ L ++ + ++ L+N S +D CLA
Sbjct: 588 PQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKN-ASLQDQGDYVCLAQD 646
Query: 410 YDYDNVSWLGSDGNILDDIELLAPIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWY 469
+ +L E +AP I N+ G SI++ C A G P P I W+
Sbjct: 647 RKTKKRHCVVRQLTVL---ERVAPTITGNLENQTTSI--GESIEVSCTASGNPPPQIMWF 701
Query: 470 KDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIYECVALNNASELRRAYTLVL 529
KD+E + +SG L N I ++++D G+Y C A + + ++
Sbjct: 702 KDNETLVEDSGIVLKDG-------NRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFII 754
Query: 530 KAEKSYTPYXXXXXXXXXXXXGMVAYLFTWKLKK--QRELTKAGLLNFKSGNKKS-FNPN 586
+ + T V +F W L R + +A K+G +P+
Sbjct: 755 EGAQEKTNLEIIILVGTA-----VIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPD 809
Query: 587 -LGIDEQADLLPYD-EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKM 644
L +DE + LPYD K+EFPR++L GK LG GAFG V +A+A GI VAVKM
Sbjct: 810 ELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKM 869
Query: 645 VKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNY 704
+K A + +AL SELKI++H+G H+N+VNLLGACTK L+VIVE+CK+GN+ Y
Sbjct: 870 LKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTK--PGGPLMVIVEFCKFGNLSTY 927
Query: 705 MQKHREVFIDQLTDNAEKNLGKINKGFLNSVGTTGTHSDYFSSGNTKDTDHSLLYSGNSK 764
++ R F+ T A GK DY + D L +S+
Sbjct: 928 LRSKRNEFVPYKTKGARFRQGK----------------DYVGAIPV-DLKRRLDSITSSQ 970
Query: 765 RSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHG 824
S S G+++++ + E + E LT HL+ ++FQ+A+GME+LA+RK +H
Sbjct: 971 SSA---SSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHR 1027
Query: 825 DLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSD 884
DLAARN+LL++ NVVKICDFGLAR +Y + +Y +K ++ LP+KW+A E + DR+++ QSD
Sbjct: 1028 DLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSD 1087
Query: 885 VWSYGIVLWEMFSLAKTPYPNIS-PTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKP 943
VWS+G++LWE+FSL +PYP + + R L +G R+ P + +Y ML CWH +P
Sbjct: 1088 VWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEP 1147
Query: 944 TARPSFTELQEILGNFLEDN 963
+ RP+F+EL E LGN L+ N
Sbjct: 1148 SQRPTFSELVEHLGNLLQAN 1167
Score = 57.6 bits (133), Expect = 2e-07
Identities = 76/331 (22%), Positives = 132/331 (39%), Gaps = 25/331 (7%)
Query: 13 IVIECRPTTPDVNVTLSSEIPDY-YYPS---FRYSPKIGFVPENSMPSDDQIISFVLCEF 68
+VI C + ++NV+L + P+ + P + K GF + M S V CE
Sbjct: 146 VVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMIS---YAGMVFCEA 202
Query: 69 VRGETRIEKYIYVSKHIKKPPKPKVAG-GHKQFLE-GETFTIHC--RVPNDGLINFKWKY 124
+ + +Y+ + V H L GE ++C R + I+F W+Y
Sbjct: 203 KINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEY 262
Query: 125 PPEVTNDSVEVSV-VKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEKDEFRK 183
P V+ +KT++ + +TI T+ G+YTC ++ +K+
Sbjct: 263 PSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFV 322
Query: 184 IFLEKPFLSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDKYLPSNDLKYNVT 243
EKPF++ + + + + I + YPP E + KN L SN
Sbjct: 323 RVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPE-IKWYKNGIPLESNH------ 375
Query: 244 TLANGDPKLRINDLKLTDIANYTLVAENKYL--TKNYTVDLRVFTKPE--AKLLNNRIIK 299
T+ G L I ++ D NYT++ N +++ V L V+ P+ K L + +
Sbjct: 376 TIKAGH-VLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDS 434
Query: 300 RLENSEMNFACKVTGYPLP-DVTWIFSNDEE 329
+ C V P P + W + +EE
Sbjct: 435 YQYGTTQTLTCTVYAIPPPHHIHWYWQLEEE 465
>AF035121-1|AAB88005.1| 1356|Homo sapiens KDR/flk-1 protein protein.
Length = 1356
Score = 336 bits (826), Expect = 3e-91
Identities = 280/980 (28%), Positives = 448/980 (45%), Gaps = 81/980 (8%)
Query: 12 KIVIECRPTTPDVNVTLSSEIPDYYYPSFRYSPKIGFVPENSMPSDDQIISFVLCEFVRG 71
K+V+ C T ++NV + ++ YPS ++ K + S ++ F+ + G
Sbjct: 241 KLVLNCTART-ELNVGIDF---NWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDG 296
Query: 72 ETRIEKYIYV------------SKHIKKPPKPKVA-GGHKQFLEGETFTIHCRVPNDGLI 118
TR ++ +Y S ++ KP VA G + L T R+P
Sbjct: 297 VTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIP----A 352
Query: 119 NFKWKYPPEVTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEK 178
+ PPE+ + + G + +TI +++ G YT +LTN +EK
Sbjct: 353 KYLGYPPPEIKWYKNGIPLESNHTIKAGHV----LTIMEVSERDTGNYTVILTNPISKEK 408
Query: 179 DEF--RKIFLEKPFLSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDKYLPSN 236
+ P + + L + + + A PP H+ + +N
Sbjct: 409 QSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECAN 468
Query: 237 DLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLT---KNYTVDLRVFTKPEAKLL 293
+ V+ + N P ++ N V +N++ KN TV V L
Sbjct: 469 EPSQAVS-VTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSAL 527
Query: 294 NN-RIIKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYLKIS 352
+ ++ E + VT P + E+ +S + S + + K+
Sbjct: 528 YKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLG 587
Query: 353 VQASGVITCNAHNSKGEYFDSSTLL---VYEINNGFGILQPLENWYSEKDSARKKCLASV 409
Q + + D+ L ++ + ++ L+N S +D CLA
Sbjct: 588 PQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKN-ASLQDQGDYVCLAQD 646
Query: 410 YDYDNVSWLGSDGNILDDIELLAPIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWY 469
+ +L E +AP I N+ G SI++ C A G P P I W+
Sbjct: 647 RKTKKRHCVVRQLTVL---ERVAPTITGNLENQTTSI--GESIEVSCTASGNPPPQIMWF 701
Query: 470 KDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIYECVALNNASELRRAYTLVL 529
KD+E + +SG L N I ++++D G+Y C A + + ++
Sbjct: 702 KDNETLVEDSGIVLKDG-------NRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFII 754
Query: 530 KAEKSYTPYXXXXXXXXXXXXGMVAYLFTWKLKK--QRELTKAGLLNFKSGNKKS-FNPN 586
+ + T V +F W L R + +A K+G +P+
Sbjct: 755 EGAQEKTNLEIIILVGTA-----VIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPD 809
Query: 587 -LGIDEQADLLPYD-EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKM 644
L +DE + LPYD K+EFPR++L GK LG GAFG V +A+A GI VAVKM
Sbjct: 810 ELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKM 869
Query: 645 VKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNY 704
+K A + +AL SELKI++H+G H+N+VNLLGACTK L+VIVE+CK+GN+ Y
Sbjct: 870 LKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTK--PGGPLMVIVEFCKFGNLSTY 927
Query: 705 MQKHREVFIDQLTDNAEKNLGKINKGFLNSVGTTGTHSDYFSSGNTKDTDHSLLYSGNSK 764
++ R F+ T A GK DY + D L +S+
Sbjct: 928 LRSKRNEFVPYKTKGARFRQGK----------------DYVGAIPV-DLKRRLDSITSSQ 970
Query: 765 RSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHG 824
S S G+++++ + E + E LT HL+ ++FQ+A+GME+LA+RK +H
Sbjct: 971 SSA---SSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHR 1027
Query: 825 DLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSD 884
DLAARN+LL++ NVVKICDFGLAR +Y + +Y +K ++ LP+KW+A E + DR+++ QSD
Sbjct: 1028 DLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSD 1087
Query: 885 VWSYGIVLWEMFSLAKTPYPNIS-PTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKP 943
VWS+G++LWE+FSL +PYP + + R L +G R+ P + +Y ML CWH +P
Sbjct: 1088 VWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEP 1147
Query: 944 TARPSFTELQEILGNFLEDN 963
+ RP+F+EL E LGN L+ N
Sbjct: 1148 SQRPTFSELVEHLGNLLQAN 1167
Score = 57.6 bits (133), Expect = 2e-07
Identities = 76/331 (22%), Positives = 132/331 (39%), Gaps = 25/331 (7%)
Query: 13 IVIECRPTTPDVNVTLSSEIPDY-YYPS---FRYSPKIGFVPENSMPSDDQIISFVLCEF 68
+VI C + ++NV+L + P+ + P + K GF + M S V CE
Sbjct: 146 VVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMIS---YAGMVFCEA 202
Query: 69 VRGETRIEKYIYVSKHIKKPPKPKVAG-GHKQFLE-GETFTIHC--RVPNDGLINFKWKY 124
+ + +Y+ + V H L GE ++C R + I+F W+Y
Sbjct: 203 KINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEY 262
Query: 125 PPEVTNDSVEVSV-VKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEKDEFRK 183
P V+ +KT++ + +TI T+ G+YTC ++ +K+
Sbjct: 263 PSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFV 322
Query: 184 IFLEKPFLSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDKYLPSNDLKYNVT 243
EKPF++ + + + + I + YPP E + KN L SN
Sbjct: 323 RVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPE-IKWYKNGIPLESNH------ 375
Query: 244 TLANGDPKLRINDLKLTDIANYTLVAENKYL--TKNYTVDLRVFTKPE--AKLLNNRIIK 299
T+ G L I ++ D NYT++ N +++ V L V+ P+ K L + +
Sbjct: 376 TIKAGH-VLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDS 434
Query: 300 RLENSEMNFACKVTGYPLP-DVTWIFSNDEE 329
+ C V P P + W + +EE
Sbjct: 435 YQYGTTQTLTCTVYAIPPPHHIHWYWQLEEE 465
>AB209901-1|BAD93138.1| 1451|Homo sapiens kinase insert domain
receptor (a type III receptor tyrosine kinase) variant
protein.
Length = 1451
Score = 336 bits (825), Expect = 3e-91
Identities = 202/542 (37%), Positives = 299/542 (55%), Gaps = 42/542 (7%)
Query: 428 IELLAPIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDI 487
+E +AP I N+ G SI++ C A G P P I W+KD+E + +SG L
Sbjct: 757 LERVAPTITGNLENQTTSI--GESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDG- 813
Query: 488 VNHTIVNSTFEIENMQEKDNGIYECVALNNASELRRAYTLVLKAEKSYTPYXXXXXXXXX 547
N I ++++D G+Y C A + + +++ + T
Sbjct: 814 ------NRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTA 867
Query: 548 XXXGMVAYLFTWKLKK--QRELTKAGLLNFKSGNKKS-FNPN-LGIDEQADLLPYD-EKF 602
V +F W L R + +A K+G +P+ L +DE + LPYD K+
Sbjct: 868 -----VIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKW 922
Query: 603 EFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELK 662
EFPR++L GK LG GAFG V +A+A GI VAVKM+K A + +AL SELK
Sbjct: 923 EFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELK 982
Query: 663 IMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDNAEK 722
I++H+G H+N+VNLLGACTK L+VIVE+CK+GN+ Y++ R F+ T A
Sbjct: 983 ILIHIGHHLNVVNLLGACTK--PGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARF 1040
Query: 723 NLGKINKGFLNSVGTTGTHSDYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQEWQTK 782
GK DY + D L +S+ S S G+++++ +
Sbjct: 1041 RQGK----------------DYVGAIPV-DLKRRLDSITSSQSSA---SSGFVEEKSLSD 1080
Query: 783 YEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKIC 842
E + E LT HL+ ++FQ+A+GME+LA+RK +H DLAARN+LL++ NVVKIC
Sbjct: 1081 VEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKIC 1140
Query: 843 DFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTP 902
DFGLAR +Y + +Y +K ++ LP+KW+A E + DR+++ QSDVWS+G++LWE+FSL +P
Sbjct: 1141 DFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASP 1200
Query: 903 YPNIS-PTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
YP + + R L +G R+ P + +Y ML CWH +P+ RP+F+EL E LGN L+
Sbjct: 1201 YPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQ 1260
Query: 962 DN 963
N
Sbjct: 1261 AN 1262
Score = 57.2 bits (132), Expect = 3e-07
Identities = 76/331 (22%), Positives = 132/331 (39%), Gaps = 25/331 (7%)
Query: 13 IVIECRPTTPDVNVTLSSEIPDY-YYPS---FRYSPKIGFVPENSMPSDDQIISFVLCEF 68
+VI C + ++NV+L + P+ + P + K GF + M S V CE
Sbjct: 241 VVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMIS---YAGMVFCEA 297
Query: 69 VRGETRIEKYIYVSKHIKKPPKPKVAG-GHKQFLE-GETFTIHC--RVPNDGLINFKWKY 124
+ + +Y+ + V H L GE ++C R + I+F W+Y
Sbjct: 298 KINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEY 357
Query: 125 PPEVTNDSVEVSV-VKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEKDEFRK 183
P V+ +KT++ + +TI T+ G+YTC ++ +K+
Sbjct: 358 PSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGITRSDQGLYTCAASSGLMTKKNSTFV 417
Query: 184 IFLEKPFLSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDKYLPSNDLKYNVT 243
EKPF++ + + + + I + YPP E + KN L SN
Sbjct: 418 RVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPE-IKWYKNGIPLESNH------ 470
Query: 244 TLANGDPKLRINDLKLTDIANYTLVAENKYL--TKNYTVDLRVFTKPE--AKLLNNRIIK 299
T+ G L I ++ D NYT++ N +++ V L V+ P+ K L + +
Sbjct: 471 TIKAGH-VLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDS 529
Query: 300 RLENSEMNFACKVTGYPLP-DVTWIFSNDEE 329
+ C V P P + W + +EE
Sbjct: 530 YQYGTTQTLTCTVYAIPPPHHIHWYWQLEEE 560
>X61656-1|CAA43837.1| 1354|Homo sapiens membrane protein protein.
Length = 1354
Score = 332 bits (815), Expect = 6e-90
Identities = 280/981 (28%), Positives = 446/981 (45%), Gaps = 83/981 (8%)
Query: 12 KIVIECRPTTPDVNVTLSSEIPDYYYPSFRYSPKIGFVPENSMPSDDQIISFVLCEFVRG 71
K+V+ C T ++NV + ++ YPS ++ K + S ++ F+ + G
Sbjct: 239 KLVLNCTART-ELNVGIDF---NWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDG 294
Query: 72 ETRIEKYIYV------------SKHIKKPPKPKVA-GGHKQFLEGETFTIHCRVPNDGLI 118
TR ++ +Y S ++ KP VA G + L T R+P
Sbjct: 295 VTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIP----A 350
Query: 119 NFKWKYPPEVTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEK 178
+ PPE+ + + G + +TI +++ G YT +LTN +EK
Sbjct: 351 KYLGYPPPEIKWYKNGIPLESNHTIKAGHV----LTIMEVSERDTGNYTVILTNPISKEK 406
Query: 179 DEF--RKIFLEKPFLSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDKYLPSN 236
+ P + + L + + + A PP H+ + +N
Sbjct: 407 QSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECAN 466
Query: 237 DLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLT---KNYTVDLRVFTKPEAKLL 293
+ V+ + N P ++ N V +N++ KN TV V L
Sbjct: 467 EPSQAVS-VTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSAL 525
Query: 294 NN-RIIKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYLKIS 352
+ ++ E + VT P + E+ +S + S + + K+
Sbjct: 526 YKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLG 585
Query: 353 VQASGVITCNAHNSKGEYFDSSTLL---VYEINNGFGILQPLENWYSEKDSARKKCLASV 409
Q + + D+ L ++ + ++ L+N S +D CLA
Sbjct: 586 PQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKN-ASLQDQGDYVCLAQD 644
Query: 410 YDYDNVSWLGSDGNILDDIELLAPIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWY 469
+ +L E +AP I N+ G SI++ C A G P P I W+
Sbjct: 645 RKTKKRHCVVRQLTVL---ERVAPTITGNLENQTTSI--GESIEVSCTASGNPPPQIMWF 699
Query: 470 KDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIYECVALN--NASELRRAYTL 527
KD+E + +SG L N I ++++D G+Y C A + +++ + +
Sbjct: 700 KDNETLVEDSGIVLKDG-------NRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFII 752
Query: 528 VLKAEKSYTPYXXXXXXXXXXXXG---MVAYLFTWKLKKQRELTKAGLLNFKSGNKKSFN 584
EK+ +V L T K EL K G L+ +
Sbjct: 753 EGAQEKTNLEIIILVGTTVIAMFFWLLLVIILGTVKRANGGEL-KTGYLSIVMDPDE--- 808
Query: 585 PNLGIDEQADLLPYD-EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVK 643
L +DE + LPYD K+EFPR++L GK LG GAFG +A+A GI VAVK
Sbjct: 809 --LPLDEHCERLPYDASKWEFPRDRLNLGKPLGRGAFGQEIEADAFGIDKTATCRTVAVK 866
Query: 644 MVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHN 703
M+K A + +AL SELKI++H+G H+N+VNLLGACTK L+VIVE+CK+GN+
Sbjct: 867 MLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTK--PGGPLMVIVEFCKFGNLST 924
Query: 704 YMQKHREVFIDQLTDNAEKNLGKINKGFLNSVGTTGTHSDYFSSGNTKDTDHSLLYSGNS 763
Y++ R F+ T A GK DY + D L +S
Sbjct: 925 YLRSKRNEFVPYKTKGARFRQGK----------------DYVGAIPV-DLKRRLDSITSS 967
Query: 764 KRSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLH 823
+ S S G+++++ + E + E LT HL+ ++FQ+A+GME+LA+RK +H
Sbjct: 968 QSSA---SSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIH 1024
Query: 824 GDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQS 883
DLAARN+LL++ NVVKICDFGLAR +Y + +Y +K ++ LP+KW+A E + DR+++ QS
Sbjct: 1025 RDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQS 1084
Query: 884 DVWSYGIVLWEMFSLAKTPYPNIS-PTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQK 942
DVWS+G++LWE+FSL +PYP + + R L +G R+ P + +Y ML CWH +
Sbjct: 1085 DVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGE 1144
Query: 943 PTARPSFTELQEILGNFLEDN 963
P+ RP+F+EL E LGN L+ N
Sbjct: 1145 PSQRPTFSELVEHLGNLLQAN 1165
Score = 57.6 bits (133), Expect = 2e-07
Identities = 76/331 (22%), Positives = 132/331 (39%), Gaps = 25/331 (7%)
Query: 13 IVIECRPTTPDVNVTLSSEIPDY-YYPS---FRYSPKIGFVPENSMPSDDQIISFVLCEF 68
+VI C + ++NV+L + P+ + P + K GF + M S V CE
Sbjct: 144 VVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMIS---YAGMVFCEA 200
Query: 69 VRGETRIEKYIYVSKHIKKPPKPKVAG-GHKQFLE-GETFTIHC--RVPNDGLINFKWKY 124
+ + +Y+ + V H L GE ++C R + I+F W+Y
Sbjct: 201 KINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEY 260
Query: 125 PPEVTNDSVEVSV-VKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEKDEFRK 183
P V+ +KT++ + +TI T+ G+YTC ++ +K+
Sbjct: 261 PSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFV 320
Query: 184 IFLEKPFLSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDKYLPSNDLKYNVT 243
EKPF++ + + + + I + YPP E + KN L SN
Sbjct: 321 RVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPE-IKWYKNGIPLESNH------ 373
Query: 244 TLANGDPKLRINDLKLTDIANYTLVAENKYL--TKNYTVDLRVFTKPE--AKLLNNRIIK 299
T+ G L I ++ D NYT++ N +++ V L V+ P+ K L + +
Sbjct: 374 TIKAGH-VLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDS 432
Query: 300 RLENSEMNFACKVTGYPLP-DVTWIFSNDEE 329
+ C V P P + W + +EE
Sbjct: 433 YQYGTTQTLTCTVYAIPPPHHIHWYWQLEEE 463
>L04947-1|AAA59459.1| 1354|Homo sapiens receptor tyrosine kinase
protein.
Length = 1354
Score = 332 bits (815), Expect = 6e-90
Identities = 280/981 (28%), Positives = 446/981 (45%), Gaps = 83/981 (8%)
Query: 12 KIVIECRPTTPDVNVTLSSEIPDYYYPSFRYSPKIGFVPENSMPSDDQIISFVLCEFVRG 71
K+V+ C T ++NV + ++ YPS ++ K + S ++ F+ + G
Sbjct: 239 KLVLNCTART-ELNVGIDF---NWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDG 294
Query: 72 ETRIEKYIYV------------SKHIKKPPKPKVA-GGHKQFLEGETFTIHCRVPNDGLI 118
TR ++ +Y S ++ KP VA G + L T R+P
Sbjct: 295 VTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIP----A 350
Query: 119 NFKWKYPPEVTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEK 178
+ PPE+ + + G + +TI +++ G YT +LTN +EK
Sbjct: 351 KYLGYPPPEIKWYKNGIPLESNHTIKAGHV----LTIMEVSERDTGNYTVILTNPISKEK 406
Query: 179 DEF--RKIFLEKPFLSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDKYLPSN 236
+ P + + L + + + A PP H+ + +N
Sbjct: 407 QSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECAN 466
Query: 237 DLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLT---KNYTVDLRVFTKPEAKLL 293
+ V+ + N P ++ N V +N++ KN TV V L
Sbjct: 467 EPSQAVS-VTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSAL 525
Query: 294 NN-RIIKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYLKIS 352
+ ++ E + VT P + E+ +S + S + + K+
Sbjct: 526 YKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLG 585
Query: 353 VQASGVITCNAHNSKGEYFDSSTLL---VYEINNGFGILQPLENWYSEKDSARKKCLASV 409
Q + + D+ L ++ + ++ L+N S +D CLA
Sbjct: 586 PQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKN-ASLQDQGDYVCLAQD 644
Query: 410 YDYDNVSWLGSDGNILDDIELLAPIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWY 469
+ +L E +AP I N+ G SI++ C A G P P I W+
Sbjct: 645 RKTKKRHCVVRQLTVL---ERVAPTITGNLENQTTSI--GESIEVSCTASGNPPPQIMWF 699
Query: 470 KDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIYECVALN--NASELRRAYTL 527
KD+E + +SG L N I ++++D G+Y C A + +++ + +
Sbjct: 700 KDNETLVEDSGIVLKDG-------NRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFII 752
Query: 528 VLKAEKSYTPYXXXXXXXXXXXXG---MVAYLFTWKLKKQRELTKAGLLNFKSGNKKSFN 584
EK+ +V L T K EL K G L+ +
Sbjct: 753 EGAQEKTNLEIIILVGTTVIAMFFWLLLVIILGTVKRANGGEL-KTGYLSIVMDPDE--- 808
Query: 585 PNLGIDEQADLLPYD-EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVK 643
L +DE + LPYD K+EFPR++L GK LG GAFG +A+A GI VAVK
Sbjct: 809 --LPLDEHCERLPYDASKWEFPRDRLNLGKPLGRGAFGQEIEADAFGIDKTATCRTVAVK 866
Query: 644 MVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHN 703
M+K A + +AL SELKI++H+G H+N+VNLLGACTK L+VIVE+CK+GN+
Sbjct: 867 MLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTK--PGGPLMVIVEFCKFGNLST 924
Query: 704 YMQKHREVFIDQLTDNAEKNLGKINKGFLNSVGTTGTHSDYFSSGNTKDTDHSLLYSGNS 763
Y++ R F+ T A GK DY + D L +S
Sbjct: 925 YLRSKRNEFVPYKTKGARFRQGK----------------DYVGAIPV-DLKRRLDSITSS 967
Query: 764 KRSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLH 823
+ S S G+++++ + E + E LT HL+ ++FQ+A+GME+LA+RK +H
Sbjct: 968 QSSA---SSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIH 1024
Query: 824 GDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQS 883
DLAARN+LL++ NVVKICDFGLAR +Y + +Y +K ++ LP+KW+A E + DR+++ QS
Sbjct: 1025 RDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQS 1084
Query: 884 DVWSYGIVLWEMFSLAKTPYPNIS-PTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQK 942
DVWS+G++LWE+FSL +PYP + + R L +G R+ P + +Y ML CWH +
Sbjct: 1085 DVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGE 1144
Query: 943 PTARPSFTELQEILGNFLEDN 963
P+ RP+F+EL E LGN L+ N
Sbjct: 1145 PSQRPTFSELVEHLGNLLQAN 1165
Score = 57.6 bits (133), Expect = 2e-07
Identities = 76/331 (22%), Positives = 132/331 (39%), Gaps = 25/331 (7%)
Query: 13 IVIECRPTTPDVNVTLSSEIPDY-YYPS---FRYSPKIGFVPENSMPSDDQIISFVLCEF 68
+VI C + ++NV+L + P+ + P + K GF + M S V CE
Sbjct: 144 VVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMIS---YAGMVFCEA 200
Query: 69 VRGETRIEKYIYVSKHIKKPPKPKVAG-GHKQFLE-GETFTIHC--RVPNDGLINFKWKY 124
+ + +Y+ + V H L GE ++C R + I+F W+Y
Sbjct: 201 KINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEY 260
Query: 125 PPEVTNDSVEVSV-VKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEKDEFRK 183
P V+ +KT++ + +TI T+ G+YTC ++ +K+
Sbjct: 261 PSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFV 320
Query: 184 IFLEKPFLSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDKYLPSNDLKYNVT 243
EKPF++ + + + + I + YPP E + KN L SN
Sbjct: 321 RVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPE-IKWYKNGIPLESNH------ 373
Query: 244 TLANGDPKLRINDLKLTDIANYTLVAENKYL--TKNYTVDLRVFTKPE--AKLLNNRIIK 299
T+ G L I ++ D NYT++ N +++ V L V+ P+ K L + +
Sbjct: 374 TIKAGH-VLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDS 432
Query: 300 RLENSEMNFACKVTGYPLP-DVTWIFSNDEE 329
+ C V P P + W + +EE
Sbjct: 433 YQYGTTQTLTCTVYAIPPPHHIHWYWQLEEE 463
>DQ836395-1|ABI53804.1| 556|Homo sapiens N2idVEGFR-1 protein.
Length = 556
Score = 312 bits (765), Expect = 6e-84
Identities = 175/434 (40%), Positives = 250/434 (57%), Gaps = 31/434 (7%)
Query: 589 IDEQADLLPYD-EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKR 647
+DEQ + LPYD K+EF RE+L GK LG GAFG V +A A GI + VAVKM+K
Sbjct: 24 LDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKE 83
Query: 648 TADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQK 707
A KAL +ELKI+ H+G H+N+VNLLGACTK L+VIVEYCKYGN+ NY++
Sbjct: 84 GATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGP--LMVIVEYCKYGNLSNYLKS 141
Query: 708 HREVFIDQLTDNAEKNLGKINKGFLNSVGTTGTHSDYFSSGNTKDTDHSLLYSGNSKRSG 767
R++F +NK + + K S+ S + SG
Sbjct: 142 KRDLFF-------------LNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSG 188
Query: 768 RKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLA 827
+ + E + +G Y P+T L+ ++FQ+ARGME+L++RK +H DLA
Sbjct: 189 FQEDKSLSDVEEEEDSDGFY------KEPITMEDLISYSFQVARGMEFLSSRKCIHRDLA 242
Query: 828 ARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWS 887
ARN+ L+++NVVKICDFGLAR +Y N +Y +K ++ LP+KW+A E + D+I+ST+SDVWS
Sbjct: 243 ARNIFLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWS 302
Query: 888 YGIVLWEMFSLAKTPYPNIS-PTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTAR 946
YG++LWE+FSL +PYP + D L +G R+ P ++ +Y +ML CWH+ P R
Sbjct: 303 YGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKER 362
Query: 947 PSFTELQEILGNFLEDN---ERNRYVDLNAPYNEMNAELMT----GEDYL-AMVCAPDYN 998
P F EL E LG+ L+ N + Y+ +NA + + ED+ + AP +N
Sbjct: 363 PRFAELVEKLGDLLQANVQQDGKDYIPINAILTGNSGFTYSTPAFSEDFFKESISAPKFN 422
Query: 999 NIVTPSPNYVNMAK 1012
+ + YVN K
Sbjct: 423 SGSSDDVRYVNAFK 436
>DQ836394-1|ABI53803.1| 556|Homo sapiens idVEGFR-1 protein.
Length = 556
Score = 312 bits (765), Expect = 6e-84
Identities = 175/434 (40%), Positives = 250/434 (57%), Gaps = 31/434 (7%)
Query: 589 IDEQADLLPYD-EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKR 647
+DEQ + LPYD K+EF RE+L GK LG GAFG V +A A GI + VAVKM+K
Sbjct: 24 LDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKE 83
Query: 648 TADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQK 707
A KAL +ELKI+ H+G H+N+VNLLGACTK L+VIVEYCKYGN+ NY++
Sbjct: 84 GATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGP--LMVIVEYCKYGNLSNYLKS 141
Query: 708 HREVFIDQLTDNAEKNLGKINKGFLNSVGTTGTHSDYFSSGNTKDTDHSLLYSGNSKRSG 767
R++F +NK + + K S+ S + SG
Sbjct: 142 KRDLFF-------------LNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSG 188
Query: 768 RKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLA 827
+ + E + +G Y P+T L+ ++FQ+ARGME+L++RK +H DLA
Sbjct: 189 FQEDKSLSDVEEEEDSDGFY------KEPITMEDLISYSFQVARGMEFLSSRKCIHRDLA 242
Query: 828 ARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWS 887
ARN+ L+++NVVKICDFGLAR +Y N +Y +K ++ LP+KW+A E + D+I+ST+SDVWS
Sbjct: 243 ARNIFLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWS 302
Query: 888 YGIVLWEMFSLAKTPYPNIS-PTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTAR 946
YG++LWE+FSL +PYP + D L +G R+ P ++ +Y +ML CWH+ P R
Sbjct: 303 YGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKER 362
Query: 947 PSFTELQEILGNFLEDN---ERNRYVDLNAPYNEMNAELMT----GEDYL-AMVCAPDYN 998
P F EL E LG+ L+ N + Y+ +NA + + ED+ + AP +N
Sbjct: 363 PRFAELVEKLGDLLQANVQQDGKDYIPINAILTGNSGFTYSTPAFSEDFFKESISAPKFN 422
Query: 999 NIVTPSPNYVNMAK 1012
+ + YVN K
Sbjct: 423 SGSSDDVRYVNAFK 436
>AB209050-1|BAD92287.1| 551|Homo sapiens fms-related tyrosine
kinase 1 (vascular endothelial growth factor/vascular
perm protein.
Length = 551
Score = 311 bits (763), Expect = 1e-83
Identities = 167/390 (42%), Positives = 235/390 (60%), Gaps = 26/390 (6%)
Query: 589 IDEQADLLPYD-EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKR 647
+DEQ + LPYD K+EF RE+L GK LG GAFG V +A A GI + VAVKM+K
Sbjct: 19 LDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKE 78
Query: 648 TADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQK 707
A KAL +ELKI+ H+G H+N+VNLLGACTK L+VIVEYCKYGN+ NY++
Sbjct: 79 GATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGP--LMVIVEYCKYGNLSNYLKS 136
Query: 708 HREVFIDQLTDNAEKNLGKINKGFLNSVGTTGTHSDYFSSGNTKDTDHSLLYSGNSKRSG 767
R++F +NK + + K S+ S + SG
Sbjct: 137 KRDLFF-------------LNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSG 183
Query: 768 RKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLA 827
+ + E + +G Y P+T L+ ++FQ+ARGME+L++RK +H DLA
Sbjct: 184 FQEDKSLSDVEEEEDSDGFY------KEPITMEDLISYSFQVARGMEFLSSRKCIHRDLA 237
Query: 828 ARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWS 887
ARN+LL+++NVVKICDFGLAR +Y N +Y +K ++ LP+KW+A E + D+I+ST+SDVWS
Sbjct: 238 ARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWS 297
Query: 888 YGIVLWEMFSLAKTPYPNIS-PTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTAR 946
YG++LWE+FSL +PYP + D L +G R+ P ++ +Y +ML CWH+ P R
Sbjct: 298 YGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKER 357
Query: 947 PSFTELQEILGNFLEDN---ERNRYVDLNA 973
P F EL E LG+ L+ N + Y+ +NA
Sbjct: 358 PRFAELVEKLGDLLQANVQQDGKDYIPINA 387
>M22734-1|AAA60048.1| 1089|Homo sapiens platelet-derived growth
factor A receptor protein.
Length = 1089
Score = 289 bits (709), Expect = 4e-77
Identities = 183/546 (33%), Positives = 284/546 (52%), Gaps = 33/546 (6%)
Query: 454 LHCEAEGVPRPTIYWY--KDDELISNNSGYKLFVDIVNHTIVN------STFE--IENMQ 503
+ C AEG P P I W KD + +N + + + + V++ I ST E + +
Sbjct: 433 VRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAK 492
Query: 504 EKDNGIYECVALNNASELRRAYTLVLKAEKS-YTPYXXXXXXXXXXXXGMVAYLFTWKLK 562
++ C+A N R LV +S T ++ + WK K
Sbjct: 493 VEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQK 552
Query: 563 KQRELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGV 622
+ E+ + ++ S + + + +D LPYD ++EFPR+ L G+ LG+GAFG
Sbjct: 553 PRYEI-RWRVIESISPDGHEY---IYVDPMQ--LPYDSRWEFPRDGLVLGRVLGSGAFGK 606
Query: 623 VYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTK 682
V + A G+ ++ VAVKM+K TA + +AL SELKIM HLG H+NIVNLLGACTK
Sbjct: 607 VVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTK 666
Query: 683 HIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDNAEKNLG--KINKGFLNS----VG 736
+ +I EYC YG++ NY+ K+R+ F+ + +K L +N ++ +
Sbjct: 667 ---SGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVIL 723
Query: 737 TTGTHSDYFSSGNTKDTDHSLLYSGN--SKRSG--RKVSEGYIQQEWQTKYEGDY--IYE 790
+ + DY T + + SK S R + + + ++ + + +
Sbjct: 724 SFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLS 783
Query: 791 CHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSM 850
LT LL + +Q+ARGME+LA++ +H DLAARNVLLA +VKICDFGLAR +
Sbjct: 784 DDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDI 843
Query: 851 YNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS-PT 909
++ Y K ++ LPVKW+A E + D +++T SDVWSYGI+LWE+FSL TPYP + +
Sbjct: 844 MHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDS 903
Query: 910 DLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYV 969
+ G R+ KP A +Y +M++CW+ +P RPSF L EI+ N L + Y
Sbjct: 904 TFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYE 963
Query: 970 DLNAPY 975
++ +
Sbjct: 964 KIHLDF 969
Score = 89.8 bits (213), Expect = 5e-17
Identities = 85/334 (25%), Positives = 150/334 (44%), Gaps = 28/334 (8%)
Query: 4 IVVPRDCSKIVIECRPTTPDVNVTLSSEIPDYYYPSFRYSPKIGFVPENSMPSDDQIISF 63
+V+ D +I CR T P+ VTL + + P+ Y + GF + +
Sbjct: 137 LVIVEDDDSAIIPCRTTDPETPVTLHNS--EGVVPA-SYDSRQGF-------NGTFTVGP 186
Query: 64 VLCEF-VRGET--RIEKYIYVSKHIKKPPKPKVAGGHKQFLEGETFTIHCRVPNDGLINF 120
+CE V+G+ I +Y K + ++ + GET + C V N+ +++
Sbjct: 187 YICEATVKGKKFQTIPFNVYALKATSELDL-EMEALKTVYKSGETIVVTCAVFNNEVVDL 245
Query: 121 KWKYPPEVTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEKDE 180
+W YP EV +++++ + +VY +T+ AT K +G Y C E K E
Sbjct: 246 QWTYPGEVKGKG--ITMLEEIKVPSIKLVY-TLTVPEATVKDSGDYECAARQATREVK-E 301
Query: 181 FRKIFL---EKPFLSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDKYLPSN- 236
+K+ + EK F+ ++ N ++ + V+E+ AYPP R +LKN+ L N
Sbjct: 302 MKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPP-PRISWLKNNLTLIENL 360
Query: 237 -DLKYNVTTL--ANGDPKLRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAKLL 293
++ +V + KL++ K D +YT+VA+N+ K+YT +L T+ + +L
Sbjct: 361 TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFEL--LTQVPSSIL 418
Query: 294 NNRIIKRLENSEMNFACKVTGYPLPDVTWIFSND 327
+ C G PLPD+ W+ D
Sbjct: 419 DLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKD 452
Score = 34.3 bits (75), Expect = 2.6
Identities = 21/69 (30%), Positives = 36/69 (52%), Gaps = 4/69 (5%)
Query: 122 WKYPPEVTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEKD-E 180
W+YP +S +V + + E +G V + + +A+ H G+YTC +T EE + E
Sbjct: 57 WQYPMS-EEESSDVEI-RNEENNSGLFVTV-LEVSSASAAHTGLYTCYYNHTQTEENELE 113
Query: 181 FRKIFLEKP 189
R I++ P
Sbjct: 114 GRHIYIYVP 122
>M21574-1|AAA96715.1| 1089|Homo sapiens platelet-derived growth
factor receptor A chain protein.
Length = 1089
Score = 289 bits (709), Expect = 4e-77
Identities = 183/546 (33%), Positives = 284/546 (52%), Gaps = 33/546 (6%)
Query: 454 LHCEAEGVPRPTIYWY--KDDELISNNSGYKLFVDIVNHTIVN------STFE--IENMQ 503
+ C AEG P P I W KD + +N + + + + V++ I ST E + +
Sbjct: 433 VRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAK 492
Query: 504 EKDNGIYECVALNNASELRRAYTLVLKAEKS-YTPYXXXXXXXXXXXXGMVAYLFTWKLK 562
++ C+A N R LV +S T ++ + WK K
Sbjct: 493 VEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQK 552
Query: 563 KQRELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGV 622
+ E+ + ++ S + + + +D LPYD ++EFPR+ L G+ LG+GAFG
Sbjct: 553 PRYEI-RWRVIESISPDGHEY---IYVDPMQ--LPYDSRWEFPRDGLVLGRVLGSGAFGK 606
Query: 623 VYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTK 682
V + A G+ ++ VAVKM+K TA + +AL SELKIM HLG H+NIVNLLGACTK
Sbjct: 607 VVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTK 666
Query: 683 HIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDNAEKNLG--KINKGFLNS----VG 736
+ +I EYC YG++ NY+ K+R+ F+ + +K L +N ++ +
Sbjct: 667 ---SGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVIL 723
Query: 737 TTGTHSDYFSSGNTKDTDHSLLYSGN--SKRSG--RKVSEGYIQQEWQTKYEGDY--IYE 790
+ + DY T + + SK S R + + + ++ + + +
Sbjct: 724 SFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLS 783
Query: 791 CHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSM 850
LT LL + +Q+ARGME+LA++ +H DLAARNVLLA +VKICDFGLAR +
Sbjct: 784 DDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDI 843
Query: 851 YNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS-PT 909
++ Y K ++ LPVKW+A E + D +++T SDVWSYGI+LWE+FSL TPYP + +
Sbjct: 844 MHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDS 903
Query: 910 DLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYV 969
+ G R+ KP A +Y +M++CW+ +P RPSF L EI+ N L + Y
Sbjct: 904 TFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYE 963
Query: 970 DLNAPY 975
++ +
Sbjct: 964 KIHLDF 969
Score = 89.8 bits (213), Expect = 5e-17
Identities = 85/334 (25%), Positives = 150/334 (44%), Gaps = 28/334 (8%)
Query: 4 IVVPRDCSKIVIECRPTTPDVNVTLSSEIPDYYYPSFRYSPKIGFVPENSMPSDDQIISF 63
+V+ D +I CR T P+ VTL + + P+ Y + GF + +
Sbjct: 137 LVIVEDDDSAIIPCRTTDPETPVTLHNS--EGVVPA-SYDSRQGF-------NGTFTVGP 186
Query: 64 VLCEF-VRGET--RIEKYIYVSKHIKKPPKPKVAGGHKQFLEGETFTIHCRVPNDGLINF 120
+CE V+G+ I +Y K + ++ + GET + C V N+ +++
Sbjct: 187 YICEATVKGKKFQTIPFNVYALKATSELDL-EMEALKTVYKSGETIVVTCAVFNNEVVDL 245
Query: 121 KWKYPPEVTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEKDE 180
+W YP EV +++++ + +VY +T+ AT K +G Y C E K E
Sbjct: 246 QWTYPGEVKGKG--ITMLEEIKVPSIKLVY-TLTVPEATVKDSGDYECAARQATREVK-E 301
Query: 181 FRKIFL---EKPFLSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDKYLPSN- 236
+K+ + EK F+ ++ N ++ + V+E+ AYPP R +LKN+ L N
Sbjct: 302 MKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPP-PRISWLKNNLTLIENL 360
Query: 237 -DLKYNVTTL--ANGDPKLRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAKLL 293
++ +V + KL++ K D +YT+VA+N+ K+YT +L T+ + +L
Sbjct: 361 TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFEL--LTQVPSSIL 418
Query: 294 NNRIIKRLENSEMNFACKVTGYPLPDVTWIFSND 327
+ C G PLPD+ W+ D
Sbjct: 419 DLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKD 452
Score = 34.3 bits (75), Expect = 2.6
Identities = 21/69 (30%), Positives = 36/69 (52%), Gaps = 4/69 (5%)
Query: 122 WKYPPEVTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEKD-E 180
W+YP +S +V + + E +G V + + +A+ H G+YTC +T EE + E
Sbjct: 57 WQYPMS-EEESSDVEI-RNEENNSGLFVTV-LEVSSASAAHTGLYTCYYNHTQTEENELE 113
Query: 181 FRKIFLEKP 189
R I++ P
Sbjct: 114 GRHIYIYVP 122
>D50017-1|BAA08742.1| 1089|Homo sapiens alpha-platelet-derived
growth factor receptor protein.
Length = 1089
Score = 289 bits (709), Expect = 4e-77
Identities = 183/546 (33%), Positives = 284/546 (52%), Gaps = 33/546 (6%)
Query: 454 LHCEAEGVPRPTIYWY--KDDELISNNSGYKLFVDIVNHTIVN------STFE--IENMQ 503
+ C AEG P P I W KD + +N + + + + V++ I ST E + +
Sbjct: 433 VRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAK 492
Query: 504 EKDNGIYECVALNNASELRRAYTLVLKAEKS-YTPYXXXXXXXXXXXXGMVAYLFTWKLK 562
++ C+A N R LV +S T ++ + WK K
Sbjct: 493 VEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQK 552
Query: 563 KQRELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGV 622
+ E+ + ++ S + + + +D LPYD ++EFPR+ L G+ LG+GAFG
Sbjct: 553 PRYEI-RWRVIESISPDGHEY---IYVDPMQ--LPYDSRWEFPRDGLVLGRVLGSGAFGK 606
Query: 623 VYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTK 682
V + A G+ ++ VAVKM+K TA + +AL SELKIM HLG H+NIVNLLGACTK
Sbjct: 607 VVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTK 666
Query: 683 HIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDNAEKNLG--KINKGFLNS----VG 736
+ +I EYC YG++ NY+ K+R+ F+ + +K L +N ++ +
Sbjct: 667 ---SGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVIL 723
Query: 737 TTGTHSDYFSSGNTKDTDHSLLYSGN--SKRSG--RKVSEGYIQQEWQTKYEGDY--IYE 790
+ + DY T + + SK S R + + + ++ + + +
Sbjct: 724 SFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLS 783
Query: 791 CHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSM 850
LT LL + +Q+ARGME+LA++ +H DLAARNVLLA +VKICDFGLAR +
Sbjct: 784 DDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDI 843
Query: 851 YNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS-PT 909
++ Y K ++ LPVKW+A E + D +++T SDVWSYGI+LWE+FSL TPYP + +
Sbjct: 844 MHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDS 903
Query: 910 DLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYV 969
+ G R+ KP A +Y +M++CW+ +P RPSF L EI+ N L + Y
Sbjct: 904 TFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYE 963
Query: 970 DLNAPY 975
++ +
Sbjct: 964 KIHLDF 969
Score = 89.8 bits (213), Expect = 5e-17
Identities = 85/334 (25%), Positives = 150/334 (44%), Gaps = 28/334 (8%)
Query: 4 IVVPRDCSKIVIECRPTTPDVNVTLSSEIPDYYYPSFRYSPKIGFVPENSMPSDDQIISF 63
+V+ D +I CR T P+ VTL + + P+ Y + GF + +
Sbjct: 137 LVIVEDDDSAIIPCRTTDPETPVTLHNS--EGVVPA-SYDSRQGF-------NGTFTVGP 186
Query: 64 VLCEF-VRGET--RIEKYIYVSKHIKKPPKPKVAGGHKQFLEGETFTIHCRVPNDGLINF 120
+CE V+G+ I +Y K + ++ + GET + C V N+ +++
Sbjct: 187 YICEATVKGKKFQTIPFNVYALKATSELDL-EMEALKTVYKSGETIVVTCAVFNNEVVDL 245
Query: 121 KWKYPPEVTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEKDE 180
+W YP EV +++++ + +VY +T+ AT K +G Y C E K E
Sbjct: 246 QWTYPGEVKGKG--ITMLEEIKVPSIKLVY-TLTVPEATVKDSGDYECAARQATREVK-E 301
Query: 181 FRKIFL---EKPFLSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDKYLPSN- 236
+K+ + EK F+ ++ N ++ + V+E+ AYPP R +LKN+ L N
Sbjct: 302 MKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPP-PRISWLKNNLTLIENL 360
Query: 237 -DLKYNVTTL--ANGDPKLRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAKLL 293
++ +V + KL++ K D +YT+VA+N+ K+YT +L T+ + +L
Sbjct: 361 TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFEL--LTQVPSSIL 418
Query: 294 NNRIIKRLENSEMNFACKVTGYPLPDVTWIFSND 327
+ C G PLPD+ W+ D
Sbjct: 419 DLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKD 452
Score = 34.3 bits (75), Expect = 2.6
Identities = 21/69 (30%), Positives = 36/69 (52%), Gaps = 4/69 (5%)
Query: 122 WKYPPEVTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEKD-E 180
W+YP +S +V + + E +G V + + +A+ H G+YTC +T EE + E
Sbjct: 57 WQYPMS-EEESSDVEI-RNEENNSGLFVTV-LEVSSASAAHTGLYTCYYNHTQTEENELE 113
Query: 181 FRKIFLEKP 189
R I++ P
Sbjct: 114 GRHIYIYVP 122
>AY229892-1|AAP69563.1| 849|Homo sapiens FIP1L1/PDGFRA fusion
protein protein.
Length = 849
Score = 280 bits (686), Expect = 2e-74
Identities = 153/393 (38%), Positives = 227/393 (57%), Gaps = 16/393 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIK 655
LPYD ++EFPR+ L G+ LG+GAFG V + A G+ ++ VAVKM+K TA + +
Sbjct: 340 LPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQ 399
Query: 656 ALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQ 715
AL SELKIM HLG H+NIVNLLGACTK + +I EYC YG++ NY+ K+R+ F+
Sbjct: 400 ALMSELKIMTHLGPHLNIVNLLGACTK---SGPIYIITEYCFYGDLVNYLHKNRDSFLSH 456
Query: 716 LTDNAEKNLG--KINKGFLNS----VGTTGTHSDYFSSGNTKDTDHSLLYSGN--SKRSG 767
+ +K L +N ++ + + + DY T + + SK S
Sbjct: 457 HPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSD 516
Query: 768 --RKVSEGYIQQEWQTKYEGDY--IYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLH 823
R + + + ++ + + + LT LL + +Q+ARGME+LA++ +H
Sbjct: 517 IQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVH 576
Query: 824 GDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQS 883
DLAARNVLLA +VKICDFGLAR + ++ Y K ++ LPVKW+A E + D +++T S
Sbjct: 577 RDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLS 636
Query: 884 DVWSYGIVLWEMFSLAKTPYPNIS-PTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQK 942
DVWSYGI+LWE+FSL TPYP + + + G R+ KP A +Y +M++CW+ +
Sbjct: 637 DVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSE 696
Query: 943 PTARPSFTELQEILGNFLEDNERNRYVDLNAPY 975
P RPSF L EI+ N L + Y ++ +
Sbjct: 697 PEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDF 729
>U63834-2|AAC50969.1| 972|Homo sapiens KIT protein protein.
Length = 972
Score = 279 bits (684), Expect = 4e-74
Identities = 182/532 (34%), Positives = 275/532 (51%), Gaps = 36/532 (6%)
Query: 454 LHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTF-------EIENMQEKD 506
L C A G P PTI WY S L VD+ F I++ K
Sbjct: 426 LQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKH 485
Query: 507 NGIYECVALNNASELRRAYTLVLKAEKSYTPYXXXXXXXXXXXXGM---VAYLFTWK-LK 562
NG EC A N+ + + K + GM + + T+K L+
Sbjct: 486 NGTVECKAYNDVGKTSAYFNFAFKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQ 545
Query: 563 KQRELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGV 622
K + ++ +GN + ID LPYD K+EFPR +L+FGK LGAGAFG
Sbjct: 546 KPMYEVQWKVVEEINGNNYVY-----IDPTQ--LPYDHKWEFPRNRLSFGKTLGAGAFGK 598
Query: 623 VYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTK 682
V +A A G+I ++ VAVKM+K +A +AL SELK++ +LG H+NIVNLLGACT
Sbjct: 599 VVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACT- 657
Query: 683 HIAKRELIVIVEYCKYGNIHNYMQKHREVFI-DQLTDNAEKNLGKINKGFLNSVGTTGTH 741
+VI EYC YG++ N++++ R+ FI + D+AE L K L+S ++ +
Sbjct: 658 --IGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAAL---YKNLLHSKESSCSD 712
Query: 742 SDYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGH 801
S + + + +RS R S YI+++ D L
Sbjct: 713 STNEYMDMKPGVSYVVPTKADKRRSVRIGS--YIERDVTPAIMED------DELALDLED 764
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
LL +++Q+A+GM +LA++ +H DLAARN+LL + KICDFGLAR + N+ Y K N
Sbjct: 765 LLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGN 824
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTD--LLRWLSDGN 919
+ LPVKW+A E + + +++ +SDVWSYGI LWE+FSL +PYP + P D + + +G
Sbjct: 825 ARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGM-PVDSKFYKMIKEGF 883
Query: 920 RLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDL 971
R+ P A +Y++M CW P RP+F ++ +++ + ++ + Y +L
Sbjct: 884 RMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNL 935
Score = 65.7 bits (153), Expect = 9e-10
Identities = 72/318 (22%), Positives = 135/318 (42%), Gaps = 40/318 (12%)
Query: 76 EKYIY-VSKHIKKPPKPKVAGGHKQFLEGETFTIHCRVPN-DGLINFKWKYPPEVTNDSV 133
EK+I V K P V+ EGE FT+ C + + + WK N
Sbjct: 198 EKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRE----NSQT 253
Query: 134 EVSVVKTEATTTGSIVYQN---ITIRNATKKHNGVYTCLLTNTCGEEKDEFRKIFLEKPF 190
++ K + G Y+ +TI +A +GV+ C NT G ++K F
Sbjct: 254 KLQE-KYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGF 312
Query: 191 LSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLK-----NDKY--LPSNDLKYNVT 243
+++ + + N +++++++E EA+P E ++ DK+ P ++ + N+
Sbjct: 313 INIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIR 372
Query: 244 TLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRLEN 303
++ +L + LK T+ YT + N + ++ V TKPE L +R++ +
Sbjct: 373 YVS----ELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEI-LTYDRLVNGM-- 425
Query: 304 SEMNFACKVTGYPLPDVTWIFSNDEEHELSST--KSEQESLYAK-TDYLKISVQAS---- 356
C G+P P + W F E S++ + ++L + + K+ VQ+S
Sbjct: 426 ----LQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSS 481
Query: 357 -----GVITCNAHNSKGE 369
G + C A+N G+
Sbjct: 482 AFKHNGTVECKAYNDVGK 499
>X69301-1|CAA49159.1| 976|Homo sapiens mast/stem cell growth
factor receptor protein.
Length = 976
Score = 277 bits (678), Expect = 2e-73
Identities = 183/536 (34%), Positives = 278/536 (51%), Gaps = 40/536 (7%)
Query: 454 LHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTF-------EIENMQEKD 506
L C A G P PTI WY S L VD+ F I++ K
Sbjct: 426 LQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKH 485
Query: 507 NGIYECVALNNASELRRAYTLVLKA--EKSYTPYXXXX--XXXXXXXXGM---VAYLFTW 559
NG EC A N+ + + K ++ P+ GM + + T+
Sbjct: 486 NGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTY 545
Query: 560 K-LKKQRELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAG 618
K L+K + ++ +GN + ID LPYD K+EFPR +L+FGK LGAG
Sbjct: 546 KYLQKPMYEVQWKVVEEINGNNYVY-----IDPTQ--LPYDHKWEFPRNRLSFGKTLGAG 598
Query: 619 AFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLG 678
AFG V +A A G+I ++ VAVKM+K +A +AL SELK++ +LG H+NIVNLLG
Sbjct: 599 AFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLG 658
Query: 679 ACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFI-DQLTDNAEKNLGKINKGFLNSVGT 737
ACT +VI EYC YG++ N++++ R+ FI + D+AE L K L+S +
Sbjct: 659 ACT---IGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAAL---YKNLLHSKES 712
Query: 738 TGTHSDYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPL 797
+ + S + + + +RS R S YI+++ D L
Sbjct: 713 SCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGS--YIERDVTPAIMED------DELAL 764
Query: 798 TSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQ 857
LL +++Q+A+GM +LA++ +H DLAARN+LL + KICDFGLAR + N+ Y
Sbjct: 765 DLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYV 824
Query: 858 KKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTD--LLRWL 915
K N+ LPVKW+A E + + +++ +SDVWSYGI LWE+FSL +PYP + P D + +
Sbjct: 825 VKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGM-PVDSKFYKMI 883
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDL 971
+G R+ P A +Y++M CW P RP+F ++ +++ + ++ + Y +L
Sbjct: 884 KEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNL 939
Score = 65.7 bits (153), Expect = 9e-10
Identities = 72/318 (22%), Positives = 135/318 (42%), Gaps = 40/318 (12%)
Query: 76 EKYIY-VSKHIKKPPKPKVAGGHKQFLEGETFTIHCRVPN-DGLINFKWKYPPEVTNDSV 133
EK+I V K P V+ EGE FT+ C + + + WK N
Sbjct: 198 EKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRE----NSQT 253
Query: 134 EVSVVKTEATTTGSIVYQN---ITIRNATKKHNGVYTCLLTNTCGEEKDEFRKIFLEKPF 190
++ K + G Y+ +TI +A +GV+ C NT G ++K F
Sbjct: 254 KLQE-KYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGF 312
Query: 191 LSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLK-----NDKY--LPSNDLKYNVT 243
+++ + + N +++++++E EA+P E ++ DK+ P ++ + N+
Sbjct: 313 INIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIR 372
Query: 244 TLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRLEN 303
++ +L + LK T+ YT + N + ++ V TKPE L +R++ +
Sbjct: 373 YVS----ELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEI-LTYDRLVNGM-- 425
Query: 304 SEMNFACKVTGYPLPDVTWIFSNDEEHELSST--KSEQESLYAK-TDYLKISVQAS---- 356
C G+P P + W F E S++ + ++L + + K+ VQ+S
Sbjct: 426 ----LQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSS 481
Query: 357 -----GVITCNAHNSKGE 369
G + C A+N G+
Sbjct: 482 AFKHNGTVECKAYNDVGK 499
>X06182-1|CAA29548.1| 976|Homo sapiens protein ( Human c-kit
proto-oncogene mRNA. ).
Length = 976
Score = 277 bits (678), Expect = 2e-73
Identities = 183/536 (34%), Positives = 278/536 (51%), Gaps = 40/536 (7%)
Query: 454 LHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTF-------EIENMQEKD 506
L C A G P PTI WY S L VD+ F I++ K
Sbjct: 426 LQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKH 485
Query: 507 NGIYECVALNNASELRRAYTLVLKA--EKSYTPYXXXX--XXXXXXXXGM---VAYLFTW 559
NG EC A N+ + + K ++ P+ GM + + T+
Sbjct: 486 NGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTY 545
Query: 560 K-LKKQRELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAG 618
K L+K + ++ +GN + ID LPYD K+EFPR +L+FGK LGAG
Sbjct: 546 KYLQKPMYEVQWKVVEEINGNNYVY-----IDPTQ--LPYDHKWEFPRNRLSFGKTLGAG 598
Query: 619 AFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLG 678
AFG V +A A G+I ++ VAVKM+K +A +AL SELK++ +LG H+NIVNLLG
Sbjct: 599 AFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLG 658
Query: 679 ACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFI-DQLTDNAEKNLGKINKGFLNSVGT 737
ACT +VI EYC YG++ N++++ R+ FI + D+AE L K L+S +
Sbjct: 659 ACT---IGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAAL---YKNLLHSKES 712
Query: 738 TGTHSDYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPL 797
+ + S + + + +RS R S YI+++ D L
Sbjct: 713 SCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGS--YIERDVTPAIMED------DELAL 764
Query: 798 TSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQ 857
LL +++Q+A+GM +LA++ +H DLAARN+LL + KICDFGLAR + N+ Y
Sbjct: 765 DLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYV 824
Query: 858 KKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTD--LLRWL 915
K N+ LPVKW+A E + + +++ +SDVWSYGI LWE+FSL +PYP + P D + +
Sbjct: 825 VKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGM-PVDSKFYKMI 883
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDL 971
+G R+ P A +Y++M CW P RP+F ++ +++ + ++ + Y +L
Sbjct: 884 KEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNL 939
Score = 65.7 bits (153), Expect = 9e-10
Identities = 72/318 (22%), Positives = 135/318 (42%), Gaps = 40/318 (12%)
Query: 76 EKYIY-VSKHIKKPPKPKVAGGHKQFLEGETFTIHCRVPN-DGLINFKWKYPPEVTNDSV 133
EK+I V K P V+ EGE FT+ C + + + WK N
Sbjct: 198 EKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRE----NSQT 253
Query: 134 EVSVVKTEATTTGSIVYQN---ITIRNATKKHNGVYTCLLTNTCGEEKDEFRKIFLEKPF 190
++ K + G Y+ +TI +A +GV+ C NT G ++K F
Sbjct: 254 KLQE-KYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGF 312
Query: 191 LSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLK-----NDKY--LPSNDLKYNVT 243
+++ + + N +++++++E EA+P E ++ DK+ P ++ + N+
Sbjct: 313 INIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIR 372
Query: 244 TLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRLEN 303
++ +L + LK T+ YT + N + ++ V TKPE L +R++ +
Sbjct: 373 YVS----ELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEI-LTYDRLVNGM-- 425
Query: 304 SEMNFACKVTGYPLPDVTWIFSNDEEHELSST--KSEQESLYAK-TDYLKISVQAS---- 356
C G+P P + W F E S++ + ++L + + K+ VQ+S
Sbjct: 426 ----LQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSS 481
Query: 357 -----GVITCNAHNSKGE 369
G + C A+N G+
Sbjct: 482 AFKHNGTVECKAYNDVGK 499
>U63834-1|AAC50968.1| 976|Homo sapiens KIT protein protein.
Length = 976
Score = 277 bits (678), Expect = 2e-73
Identities = 183/536 (34%), Positives = 278/536 (51%), Gaps = 40/536 (7%)
Query: 454 LHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTF-------EIENMQEKD 506
L C A G P PTI WY S L VD+ F I++ K
Sbjct: 426 LQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKH 485
Query: 507 NGIYECVALNNASELRRAYTLVLKA--EKSYTPYXXXX--XXXXXXXXGM---VAYLFTW 559
NG EC A N+ + + K ++ P+ GM + + T+
Sbjct: 486 NGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTY 545
Query: 560 K-LKKQRELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAG 618
K L+K + ++ +GN + ID LPYD K+EFPR +L+FGK LGAG
Sbjct: 546 KYLQKPMYEVQWKVVEEINGNNYVY-----IDPTQ--LPYDHKWEFPRNRLSFGKTLGAG 598
Query: 619 AFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLG 678
AFG V +A A G+I ++ VAVKM+K +A +AL SELK++ +LG H+NIVNLLG
Sbjct: 599 AFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLG 658
Query: 679 ACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFI-DQLTDNAEKNLGKINKGFLNSVGT 737
ACT +VI EYC YG++ N++++ R+ FI + D+AE L K L+S +
Sbjct: 659 ACT---IGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAAL---YKNLLHSKES 712
Query: 738 TGTHSDYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPL 797
+ + S + + + +RS R S YI+++ D L
Sbjct: 713 SCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGS--YIERDVTPAIMED------DELAL 764
Query: 798 TSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQ 857
LL +++Q+A+GM +LA++ +H DLAARN+LL + KICDFGLAR + N+ Y
Sbjct: 765 DLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYV 824
Query: 858 KKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTD--LLRWL 915
K N+ LPVKW+A E + + +++ +SDVWSYGI LWE+FSL +PYP + P D + +
Sbjct: 825 VKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGM-PVDSKFYKMI 883
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDL 971
+G R+ P A +Y++M CW P RP+F ++ +++ + ++ + Y +L
Sbjct: 884 KEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNL 939
Score = 65.7 bits (153), Expect = 9e-10
Identities = 72/318 (22%), Positives = 135/318 (42%), Gaps = 40/318 (12%)
Query: 76 EKYIY-VSKHIKKPPKPKVAGGHKQFLEGETFTIHCRVPN-DGLINFKWKYPPEVTNDSV 133
EK+I V K P V+ EGE FT+ C + + + WK N
Sbjct: 198 EKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRE----NSQT 253
Query: 134 EVSVVKTEATTTGSIVYQN---ITIRNATKKHNGVYTCLLTNTCGEEKDEFRKIFLEKPF 190
++ K + G Y+ +TI +A +GV+ C NT G ++K F
Sbjct: 254 KLQE-KYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGF 312
Query: 191 LSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLK-----NDKY--LPSNDLKYNVT 243
+++ + + N +++++++E EA+P E ++ DK+ P ++ + N+
Sbjct: 313 INIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIR 372
Query: 244 TLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRLEN 303
++ +L + LK T+ YT + N + ++ V TKPE L +R++ +
Sbjct: 373 YVS----ELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEI-LTYDRLVNGM-- 425
Query: 304 SEMNFACKVTGYPLPDVTWIFSNDEEHELSST--KSEQESLYAK-TDYLKISVQAS---- 356
C G+P P + W F E S++ + ++L + + K+ VQ+S
Sbjct: 426 ----LQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSS 481
Query: 357 -----GVITCNAHNSKGE 369
G + C A+N G+
Sbjct: 482 AFKHNGTVECKAYNDVGK 499
>BC071593-1|AAH71593.1| 976|Homo sapiens KIT protein protein.
Length = 976
Score = 276 bits (676), Expect = 4e-73
Identities = 182/536 (33%), Positives = 278/536 (51%), Gaps = 40/536 (7%)
Query: 454 LHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTF-------EIENMQEKD 506
L C A G P PTI WY S L VD+ F I++ K
Sbjct: 426 LQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKH 485
Query: 507 NGIYECVALNNASELRRAYTLVLKA--EKSYTPYXXXX--XXXXXXXXGM---VAYLFTW 559
NG EC A N+ + + K ++ P+ GM + + T+
Sbjct: 486 NGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTY 545
Query: 560 K-LKKQRELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAG 618
K L+K + ++ +GN + ID LPYD K+EFPR +L+FGK LGAG
Sbjct: 546 KYLQKPMYEVQWKVVEEINGNNYVY-----IDPTQ--LPYDHKWEFPRNRLSFGKTLGAG 598
Query: 619 AFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLG 678
AFG V +A A G+I ++ VAVKM+K +A +AL SELK++ +LG H+NIVNLLG
Sbjct: 599 AFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLG 658
Query: 679 ACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFI-DQLTDNAEKNLGKINKGFLNSVGT 737
ACT +VI EYC YG++ N++++ R+ FI + D+AE L K L+S +
Sbjct: 659 ACT---IGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAAL---YKNLLHSKES 712
Query: 738 TGTHSDYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPL 797
+ + S + + + +RS R S YI+++ D +
Sbjct: 713 SCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGS--YIERDVTPAIMED------DELAI 764
Query: 798 TSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQ 857
LL +++Q+A+GM +LA++ +H DLAARN+LL + KICDFGLAR + N+ Y
Sbjct: 765 DLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYV 824
Query: 858 KKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTD--LLRWL 915
K N+ LPVKW+A E + + +++ +SDVWSYGI LWE+FSL +PYP + P D + +
Sbjct: 825 VKGNARLPVKWMAHESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGM-PVDSKFYKMI 883
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDL 971
+G R+ P A +Y++M CW P RP+F ++ +++ + ++ + Y +L
Sbjct: 884 KEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNL 939
Score = 65.7 bits (153), Expect = 9e-10
Identities = 72/318 (22%), Positives = 135/318 (42%), Gaps = 40/318 (12%)
Query: 76 EKYIY-VSKHIKKPPKPKVAGGHKQFLEGETFTIHCRVPN-DGLINFKWKYPPEVTNDSV 133
EK+I V K P V+ EGE FT+ C + + + WK N
Sbjct: 198 EKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRE----NSQT 253
Query: 134 EVSVVKTEATTTGSIVYQN---ITIRNATKKHNGVYTCLLTNTCGEEKDEFRKIFLEKPF 190
++ K + G Y+ +TI +A +GV+ C NT G ++K F
Sbjct: 254 KLQE-KYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGF 312
Query: 191 LSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLK-----NDKY--LPSNDLKYNVT 243
+++ + + N +++++++E EA+P E ++ DK+ P ++ + N+
Sbjct: 313 INIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIR 372
Query: 244 TLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRLEN 303
++ +L + LK T+ YT + N + ++ V TKPE L +R++ +
Sbjct: 373 YVS----ELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEI-LTYDRLVNGM-- 425
Query: 304 SEMNFACKVTGYPLPDVTWIFSNDEEHELSST--KSEQESLYAK-TDYLKISVQAS---- 356
C G+P P + W F E S++ + ++L + + K+ VQ+S
Sbjct: 426 ----LQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSS 481
Query: 357 -----GVITCNAHNSKGE 369
G + C A+N G+
Sbjct: 482 AFKHNGTVECKAYNDVGK 499
>M21616-1|AAA36427.1| 1106|Homo sapiens platelet-derived growth
factor receptor protein.
Length = 1106
Score = 265 bits (650), Expect = 5e-70
Identities = 144/397 (36%), Positives = 229/397 (57%), Gaps = 23/397 (5%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIK 655
LPYD +E PR++L G+ LG+GAFG V +A A G+ +++ T VAVKM+K TA + +
Sbjct: 587 LPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQ 646
Query: 656 ALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQ 715
AL SELKIM HLG H+N+VNLLGACTK + +I EYC+YG++ +Y+ +++ F+
Sbjct: 647 ALMSELKIMSHLGPHLNVVNLLGACTKG---GPIYIITEYCRYGDLVDYLHRNKHTFLQH 703
Query: 716 LTDNAEKNLGKINKGFL-------NSVGTTG-THSDYFSSGNTKDTDH--SLLYSGNSKR 765
+D ++ L + V TG + Y + D+ L G+ K
Sbjct: 704 HSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKY 763
Query: 766 SGRKVS------EGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANR 819
+ + S + Y+ + I E P L+ L+G+++Q+A GME+LA++
Sbjct: 764 ADIESSNYMAPYDNYVPSAPERTCRATLINE--SP-VLSYMDLVGFSYQVANGMEFLASK 820
Query: 820 KVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIF 879
+H DLAARNVL+ + +VKICDFGLAR + + Y K ++ LP+KW+A E + + ++
Sbjct: 821 NCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLY 880
Query: 880 STQSDVWSYGIVLWEMFSLAKTPYPNISPTD-LLRWLSDGNRLEKPPFADDRLYNVMLRC 938
+T SDVWS+GI+LWE+F+L TPYP + + + G R+ +P A D +Y +M +C
Sbjct: 881 TTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKC 940
Query: 939 WHQKPTARPSFTELQEILGNFLEDNERNRYVDLNAPY 975
W +K RP F++L +L L + + +Y ++ +
Sbjct: 941 WEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEF 977
Score = 59.3 bits (137), Expect = 8e-08
Identities = 69/326 (21%), Positives = 132/326 (40%), Gaps = 20/326 (6%)
Query: 9 DCSKIVIECRPTTPDVNVTLSSEIPDYYYPSFRYSPKIGFVPENSMPSDDQIISFVLCEF 68
+ ++I I CR T P + VTL + D P Y + GF S +D+ S++ C+
Sbjct: 141 EITEITIPCRVTDPQLVVTLHEKKGDVALP-VPYDHQRGF----SGIFEDR--SYI-CKT 192
Query: 69 VRGETRIEKYIYVSKHIKKPP-KPKVAGGHKQFLEGETFTIHCRVPNDGLINFKWKYPPE 127
G+ ++ Y ++ V +GE T+ C V + ++NF+W YP +
Sbjct: 193 TIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNDVVNFEWTYPRK 252
Query: 128 VTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEKDE--FRKIF 185
+ VE V + + I +A + +G YTC +T + + +DE
Sbjct: 253 ESGRLVE--PVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITV 310
Query: 186 LEKPFLSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDKYLPSNDLKYNVTTL 245
+E ++ L ++S + + EAYPP F N S+ + ++T
Sbjct: 311 VESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTR 370
Query: 246 ANGDPK----LRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRL 301
+ + L + +K+ + +YT+ A ++ + L++ L+
Sbjct: 371 NVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSE---SHP 427
Query: 302 ENSEMNFACKVTGYPLPDVTWIFSND 327
++ E C+ G P P++ W D
Sbjct: 428 DSGEQTVRCRGRGMPQPNIIWSACRD 453
>J03278-1|AAA60049.1| 1106|Homo sapiens platelet-derived growth
factor receptor protein.
Length = 1106
Score = 265 bits (650), Expect = 5e-70
Identities = 144/397 (36%), Positives = 229/397 (57%), Gaps = 23/397 (5%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIK 655
LPYD +E PR++L G+ LG+GAFG V +A A G+ +++ T VAVKM+K TA + +
Sbjct: 587 LPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQ 646
Query: 656 ALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQ 715
AL SELKIM HLG H+N+VNLLGACTK + +I EYC+YG++ +Y+ +++ F+
Sbjct: 647 ALMSELKIMSHLGPHLNVVNLLGACTKG---GPIYIITEYCRYGDLVDYLHRNKHTFLQH 703
Query: 716 LTDNAEKNLGKINKGFL-------NSVGTTG-THSDYFSSGNTKDTDH--SLLYSGNSKR 765
+D ++ L + V TG + Y + D+ L G+ K
Sbjct: 704 HSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKY 763
Query: 766 SGRKVS------EGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANR 819
+ + S + Y+ + I E P L+ L+G+++Q+A GME+LA++
Sbjct: 764 ADIESSNYMAPYDNYVPSAPERTCRATLINE--SP-VLSYMDLVGFSYQVANGMEFLASK 820
Query: 820 KVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIF 879
+H DLAARNVL+ + +VKICDFGLAR + + Y K ++ LP+KW+A E + + ++
Sbjct: 821 NCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLY 880
Query: 880 STQSDVWSYGIVLWEMFSLAKTPYPNISPTD-LLRWLSDGNRLEKPPFADDRLYNVMLRC 938
+T SDVWS+GI+LWE+F+L TPYP + + + G R+ +P A D +Y +M +C
Sbjct: 881 TTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKC 940
Query: 939 WHQKPTARPSFTELQEILGNFLEDNERNRYVDLNAPY 975
W +K RP F++L +L L + + +Y ++ +
Sbjct: 941 WEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEF 977
Score = 58.8 bits (136), Expect = 1e-07
Identities = 69/326 (21%), Positives = 132/326 (40%), Gaps = 20/326 (6%)
Query: 9 DCSKIVIECRPTTPDVNVTLSSEIPDYYYPSFRYSPKIGFVPENSMPSDDQIISFVLCEF 68
+ ++I I CR T P + VTL + D P Y + GF S +D+ S++ C+
Sbjct: 141 EITEITIPCRVTDPQLVVTLHEKKGDVALP-VPYDHQRGF----SGIFEDR--SYI-CKT 192
Query: 69 VRGETRIEKYIYVSKHIKKPP-KPKVAGGHKQFLEGETFTIHCRVPNDGLINFKWKYPPE 127
G+ ++ Y ++ V +GE T+ C V + ++NF+W YP +
Sbjct: 193 TIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRK 252
Query: 128 VTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEKDE--FRKIF 185
+ VE V + + I +A + +G YTC +T + + +DE
Sbjct: 253 ESGRLVE--PVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITV 310
Query: 186 LEKPFLSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDKYLPSNDLKYNVTTL 245
+E ++ L ++S + + EAYPP F N S+ + ++T
Sbjct: 311 VESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTR 370
Query: 246 ANGDPK----LRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRL 301
+ + L + +K+ + +YT+ A ++ + L++ L+
Sbjct: 371 NVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSE---SHP 427
Query: 302 ENSEMNFACKVTGYPLPDVTWIFSND 327
++ E C+ G P P++ W D
Sbjct: 428 DSGEQTVRCRGRGMPQPNIIWSACRD 453
>BC032224-1|AAH32224.1| 1106|Homo sapiens platelet-derived growth
factor receptor, beta polypeptide protein.
Length = 1106
Score = 265 bits (650), Expect = 5e-70
Identities = 144/397 (36%), Positives = 229/397 (57%), Gaps = 23/397 (5%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIK 655
LPYD +E PR++L G+ LG+GAFG V +A A G+ +++ T VAVKM+K TA + +
Sbjct: 587 LPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQ 646
Query: 656 ALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQ 715
AL SELKIM HLG H+N+VNLLGACTK + +I EYC+YG++ +Y+ +++ F+
Sbjct: 647 ALMSELKIMSHLGPHLNVVNLLGACTKG---GPIYIITEYCRYGDLVDYLHRNKHTFLQH 703
Query: 716 LTDNAEKNLGKINKGFL-------NSVGTTG-THSDYFSSGNTKDTDH--SLLYSGNSKR 765
+D ++ L + V TG + Y + D+ L G+ K
Sbjct: 704 HSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKY 763
Query: 766 SGRKVS------EGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANR 819
+ + S + Y+ + I E P L+ L+G+++Q+A GME+LA++
Sbjct: 764 ADIESSNYMAPYDNYVPSAPERTCRATLINE--SP-VLSYMDLVGFSYQVANGMEFLASK 820
Query: 820 KVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIF 879
+H DLAARNVL+ + +VKICDFGLAR + + Y K ++ LP+KW+A E + + ++
Sbjct: 821 NCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLY 880
Query: 880 STQSDVWSYGIVLWEMFSLAKTPYPNISPTD-LLRWLSDGNRLEKPPFADDRLYNVMLRC 938
+T SDVWS+GI+LWE+F+L TPYP + + + G R+ +P A D +Y +M +C
Sbjct: 881 TTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKC 940
Query: 939 WHQKPTARPSFTELQEILGNFLEDNERNRYVDLNAPY 975
W +K RP F++L +L L + + +Y ++ +
Sbjct: 941 WEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEF 977
Score = 57.6 bits (133), Expect = 2e-07
Identities = 68/326 (20%), Positives = 128/326 (39%), Gaps = 20/326 (6%)
Query: 9 DCSKIVIECRPTTPDVNVTLSSEIPDYYYPSFRYSPKIGFVPENSMPSDDQIISFVLCEF 68
+ ++I I CR T P + VTL + D P Y + GF + D I C+
Sbjct: 141 EITEITIPCRVTDPQLVVTLHEKKGDVALP-VPYDHQRGFF---GIFEDRSYI----CKT 192
Query: 69 VRGETRIEKYIYVSKHIKKPP-KPKVAGGHKQFLEGETFTIHCRVPNDGLINFKWKYPPE 127
G+ ++ Y ++ V +GE T+ C V + ++NF+W YP +
Sbjct: 193 TIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRK 252
Query: 128 VTNDSVEVSVVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCGEEKDE--FRKIF 185
+ VE V + + I +A + +G YTC +T + + +DE
Sbjct: 253 ESGRLVE--PVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITV 310
Query: 186 LEKPFLSLRDLAKGKLMGNANKSINIVIEIEAYPPVERTHFLKNDKYLPSNDLKYNVTTL 245
+E ++ L ++S + + EAYPP F N S+ + ++T
Sbjct: 311 VESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTR 370
Query: 246 ANGDPK----LRINDLKLTDIANYTLVAENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRL 301
+ + L + +K+ + +YT+ A ++ + L++ L+
Sbjct: 371 NVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSE---SHP 427
Query: 302 ENSEMNFACKVTGYPLPDVTWIFSND 327
++ E C+ G P P++ W D
Sbjct: 428 DSGEQTVRCRGRGMPQPNIIWSACRD 453
>AB209657-1|BAD92894.1| 777|Homo sapiens platelet-derived growth
factor receptor beta precursor variant protein.
Length = 777
Score = 265 bits (650), Expect = 5e-70
Identities = 144/397 (36%), Positives = 229/397 (57%), Gaps = 23/397 (5%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIK 655
LPYD +E PR++L G+ LG+GAFG V +A A G+ +++ T VAVKM+K TA + +
Sbjct: 258 LPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQ 317
Query: 656 ALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQ 715
AL SELKIM HLG H+N+VNLLGACTK + +I EYC+YG++ +Y+ +++ F+
Sbjct: 318 ALMSELKIMSHLGPHLNVVNLLGACTKG---GPIYIITEYCRYGDLVDYLHRNKHTFLQH 374
Query: 716 LTDNAEKNLGKINKGFL-------NSVGTTG-THSDYFSSGNTKDTDH--SLLYSGNSKR 765
+D ++ L + V TG + Y + D+ L G+ K
Sbjct: 375 HSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKY 434
Query: 766 SGRKVS------EGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANR 819
+ + S + Y+ + I E P L+ L+G+++Q+A GME+LA++
Sbjct: 435 ADIESSNYMAPYDNYVPSAPERTCRATLINE--SP-VLSYMDLVGFSYQVANGMEFLASK 491
Query: 820 KVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIF 879
+H DLAARNVL+ + +VKICDFGLAR + + Y K ++ LP+KW+A E + + ++
Sbjct: 492 NCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLY 551
Query: 880 STQSDVWSYGIVLWEMFSLAKTPYPNISPTD-LLRWLSDGNRLEKPPFADDRLYNVMLRC 938
+T SDVWS+GI+LWE+F+L TPYP + + + G R+ +P A D +Y +M +C
Sbjct: 552 TTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKC 611
Query: 939 WHQKPTARPSFTELQEILGNFLEDNERNRYVDLNAPY 975
W +K RP F++L +L L + + +Y ++ +
Sbjct: 612 WEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEF 648
>Z26652-1|CAA81393.1| 993|Homo sapiens FLT3 receptor tyrosine
kinase precursor protein.
Length = 993
Score = 263 bits (644), Expect = 3e-69
Identities = 158/382 (41%), Positives = 217/382 (56%), Gaps = 18/382 (4%)
Query: 598 YDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKAL 657
YD K+EFPRE L FGK LG+GAFG V A A GI V+ VAVKM+K AD+ +AL
Sbjct: 599 YDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREAL 658
Query: 658 ASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLT 717
SELK+M LG H NIVNLLGACT + +I EYC YG++ NY++ RE F T
Sbjct: 659 MSELKMMTQLGSHENIVNLLGACT---LSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWT 715
Query: 718 DNAEKNLGKINKGFLNSVGTTGTHSDYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQ 777
+ +++ F + ++ S D+D GNS S E I+
Sbjct: 716 EIFKEHNFSFYPTFQSHPNSSMPGSREVQIH--PDSDQISGLHGNSFHS-----EDEIEY 768
Query: 778 EWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDN 837
E Q + E E LT LL +A+Q+A+GME+L + +H DLAARNVL+
Sbjct: 769 ENQKRLE-----EEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGK 823
Query: 838 VVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFS 897
VVKICDFGLAR + ++ Y + N+ LPVKW+A E + + I++ +SDVWSYGI+LWE+FS
Sbjct: 824 VVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFS 883
Query: 898 LAKTPYPNISPTD--LLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEI 955
L PYP I P D + + +G ++++P +A + +Y +M CW RPSF L
Sbjct: 884 LGVNPYPGI-PVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSF 942
Query: 956 LGNFLEDNERNRYVDLNAPYNE 977
LG L D E Y +++ +E
Sbjct: 943 LGCQLADAEEAMYQNVDGRVSE 964
>U02687-1|AAA18947.1| 993|Homo sapiens serine/threonine protein
kinase protein.
Length = 993
Score = 263 bits (644), Expect = 3e-69
Identities = 158/382 (41%), Positives = 217/382 (56%), Gaps = 18/382 (4%)
Query: 598 YDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKAL 657
YD K+EFPRE L FGK LG+GAFG V A A GI V+ VAVKM+K AD+ +AL
Sbjct: 599 YDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREAL 658
Query: 658 ASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLT 717
SELK+M LG H NIVNLLGACT + +I EYC YG++ NY++ RE F T
Sbjct: 659 MSELKMMTQLGSHENIVNLLGACT---LSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWT 715
Query: 718 DNAEKNLGKINKGFLNSVGTTGTHSDYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQ 777
+ +++ F + ++ S D+D GNS S E I+
Sbjct: 716 EIFKEHNFSFYPTFQSHPNSSMPGSREVQIH--PDSDQISGLHGNSFHS-----EDEIEY 768
Query: 778 EWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDN 837
E Q + E E LT LL +A+Q+A+GME+L + +H DLAARNVL+
Sbjct: 769 ENQKRLE-----EEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGK 823
Query: 838 VVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFS 897
VVKICDFGLAR + ++ Y + N+ LPVKW+A E + + I++ +SDVWSYGI+LWE+FS
Sbjct: 824 VVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFS 883
Query: 898 LAKTPYPNISPTD--LLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEI 955
L PYP I P D + + +G ++++P +A + +Y +M CW RPSF L
Sbjct: 884 LGVNPYPGI-PVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSF 942
Query: 956 LGNFLEDNERNRYVDLNAPYNE 977
LG L D E Y +++ +E
Sbjct: 943 LGCQLADAEEAMYQNVDGRVSE 964
>BC126350-1|AAI26351.1| 993|Homo sapiens fms-related tyrosine
kinase 3 protein.
Length = 993
Score = 263 bits (644), Expect = 3e-69
Identities = 158/382 (41%), Positives = 217/382 (56%), Gaps = 18/382 (4%)
Query: 598 YDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKAL 657
YD K+EFPRE L FGK LG+GAFG V A A GI V+ VAVKM+K AD+ +AL
Sbjct: 599 YDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREAL 658
Query: 658 ASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLT 717
SELK+M LG H NIVNLLGACT + +I EYC YG++ NY++ RE F T
Sbjct: 659 MSELKMMTQLGSHENIVNLLGACT---LSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWT 715
Query: 718 DNAEKNLGKINKGFLNSVGTTGTHSDYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQ 777
+ +++ F + ++ S D+D GNS S E I+
Sbjct: 716 EIFKEHNFSFYPTFQSHPNSSMPGSREVQIH--PDSDQISGLHGNSFHS-----EDEIEY 768
Query: 778 EWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDN 837
E Q + E E LT LL +A+Q+A+GME+L + +H DLAARNVL+
Sbjct: 769 ENQKRLE-----EEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGK 823
Query: 838 VVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFS 897
VVKICDFGLAR + ++ Y + N+ LPVKW+A E + + I++ +SDVWSYGI+LWE+FS
Sbjct: 824 VVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFS 883
Query: 898 LAKTPYPNISPTD--LLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEI 955
L PYP I P D + + +G ++++P +A + +Y +M CW RPSF L
Sbjct: 884 LGVNPYPGI-PVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSF 942
Query: 956 LGNFLEDNERNRYVDLNAPYNE 977
LG L D E Y +++ +E
Sbjct: 943 LGCQLADAEEAMYQNVDGRVSE 964
>X03663-1|CAA27300.1| 972|Homo sapiens protein ( Human mRNA for
c-fms proto-oncogene. ).
Length = 972
Score = 262 bits (643), Expect = 4e-69
Identities = 179/532 (33%), Positives = 267/532 (50%), Gaps = 36/532 (6%)
Query: 454 LHCEAEGVPRPTIYWYK--------DDELISN--NSGYK--LFVDIVNHTIVNSTFEIEN 501
L C A G P+P + W + D+ + + Y L + + V S +E
Sbjct: 417 LLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVET 476
Query: 502 MQEKDNGIYECVALNNASELRRAYTLVLKAEKSYTPYXXXXXXXXXXXXGMVAYLFTWKL 561
++ N YEC A N+ A+ + ++ P ++A L L
Sbjct: 477 LEH--NQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLL 534
Query: 562 KKQRELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFG 621
+ + + +S+ N LPY+EK+EFPR L FGK LGAGAFG
Sbjct: 535 LLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFG 594
Query: 622 VVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACT 681
V +A A G+ + VAVKM+K TA +AL SELKIM HLG+H NIVNLLGACT
Sbjct: 595 KVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACT 654
Query: 682 KHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDNAEKNLGKINKGFLNSVGTTGTH 741
++VI EYC YG++ N++++ E + + G ++ ++
Sbjct: 655 HG---GPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR 711
Query: 742 SDYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGH 801
FSS + D + S S SE + +E +G RPL
Sbjct: 712 DSGFSS---QGVDTYVEMRPVSTSSNDSFSEQDLDKE-----DG---------RPLELRD 754
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
LL ++ Q+A+GM +LA++ +H D+AARNVLL + +V KI DFGLAR + N+ Y K N
Sbjct: 755 LLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGN 814
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNI-SPTDLLRWLSDGNR 920
+ LPVKW+A E + D +++ QSDVWSYGI+LWE+FSL PYP I + + + DG +
Sbjct: 815 ARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQ 874
Query: 921 LEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNR-YVDL 971
+ +P FA +Y++M CW +PT RP+F ++ L +++ R R Y +L
Sbjct: 875 MAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNL 926
Score = 48.4 bits (110), Expect = 1e-04
Identities = 52/234 (22%), Positives = 93/234 (39%), Gaps = 20/234 (8%)
Query: 150 YQNITIRNATK---KHNGVYTCLLTNTCGEEKDEFRKIFLEKPFLSLRDLAKGKLMGNAN 206
YQ + N + +H G Y+C+ +N G+ +E +L+L
Sbjct: 257 YQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVG 316
Query: 207 KSINIVIEIEAYPPVER---THFLKNDKYLPSNDLKYNVTT--LANGDPKLRINDLKLTD 261
+ +N+ + +EAYP ++ T+ + P L N TT L + LK ++
Sbjct: 317 EGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLA-NATTKDTYRHTFTLSLPRLKPSE 375
Query: 262 IANYTLVAENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRLENSEMNFACKVTGYPLPDVT 321
Y+ +A N + T +L + PE ++ I N C +GYP P+VT
Sbjct: 376 AGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFI-----NGSGTLLCAASGYPQPNVT 430
Query: 322 WIFSN------DEEHELSSTKSEQESLYAKTDYLKISVQASGVITCNAHNSKGE 369
W+ + DE L + ++ + K++VQ+ + HN E
Sbjct: 431 WLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYE 484
>U63963-1|AAB51696.1| 972|Homo sapiens CSF-1 receptor protein.
Length = 972
Score = 262 bits (643), Expect = 4e-69
Identities = 179/532 (33%), Positives = 267/532 (50%), Gaps = 36/532 (6%)
Query: 454 LHCEAEGVPRPTIYWYK--------DDELISN--NSGYK--LFVDIVNHTIVNSTFEIEN 501
L C A G P+P + W + D+ + + Y L + + V S +E
Sbjct: 417 LLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVET 476
Query: 502 MQEKDNGIYECVALNNASELRRAYTLVLKAEKSYTPYXXXXXXXXXXXXGMVAYLFTWKL 561
++ N YEC A N+ A+ + ++ P ++A L L
Sbjct: 477 LEH--NQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLL 534
Query: 562 KKQRELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFG 621
+ + + +S+ N LPY+EK+EFPR L FGK LGAGAFG
Sbjct: 535 LLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFG 594
Query: 622 VVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACT 681
V +A A G+ + VAVKM+K TA +AL SELKIM HLG+H NIVNLLGACT
Sbjct: 595 KVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACT 654
Query: 682 KHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDNAEKNLGKINKGFLNSVGTTGTH 741
++VI EYC YG++ N++++ E + + G ++ ++
Sbjct: 655 HG---GPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR 711
Query: 742 SDYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGH 801
FSS + D + S S SE + +E +G RPL
Sbjct: 712 DSGFSS---QGVDTYVEMRPVSTSSNDSFSEQDLDKE-----DG---------RPLELRD 754
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
LL ++ Q+A+GM +LA++ +H D+AARNVLL + +V KI DFGLAR + N+ Y K N
Sbjct: 755 LLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGN 814
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNI-SPTDLLRWLSDGNR 920
+ LPVKW+A E + D +++ QSDVWSYGI+LWE+FSL PYP I + + + DG +
Sbjct: 815 ARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQ 874
Query: 921 LEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNR-YVDL 971
+ +P FA +Y++M CW +PT RP+F ++ L +++ R R Y +L
Sbjct: 875 MAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNL 926
Score = 48.4 bits (110), Expect = 1e-04
Identities = 52/234 (22%), Positives = 93/234 (39%), Gaps = 20/234 (8%)
Query: 150 YQNITIRNATK---KHNGVYTCLLTNTCGEEKDEFRKIFLEKPFLSLRDLAKGKLMGNAN 206
YQ + N + +H G Y+C+ +N G+ +E +L+L
Sbjct: 257 YQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVG 316
Query: 207 KSINIVIEIEAYPPVER---THFLKNDKYLPSNDLKYNVTT--LANGDPKLRINDLKLTD 261
+ +N+ + +EAYP ++ T+ + P L N TT L + LK ++
Sbjct: 317 EGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLA-NATTKDTYRHTFTLSLPRLKPSE 375
Query: 262 IANYTLVAENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRLENSEMNFACKVTGYPLPDVT 321
Y+ +A N + T +L + PE ++ I N C +GYP P+VT
Sbjct: 376 AGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFI-----NGSGTLLCAASGYPQPNVT 430
Query: 322 WIFSN------DEEHELSSTKSEQESLYAKTDYLKISVQASGVITCNAHNSKGE 369
W+ + DE L + ++ + K++VQ+ + HN E
Sbjct: 431 WLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYE 484
>BC047521-1|AAH47521.1| 972|Homo sapiens colony stimulating factor
1 receptor, formerly McDonough feline sarcoma viral (
protein.
Length = 972
Score = 261 bits (640), Expect = 9e-69
Identities = 178/532 (33%), Positives = 267/532 (50%), Gaps = 36/532 (6%)
Query: 454 LHCEAEGVPRPTIYWYK--------DDELISN--NSGYK--LFVDIVNHTIVNSTFEIEN 501
L C A G P+P + W + D+ + + Y L + + V S +E
Sbjct: 417 LLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVET 476
Query: 502 MQEKDNGIYECVALNNASELRRAYTLVLKAEKSYTPYXXXXXXXXXXXXGMVAYLFTWKL 561
++ N YEC A N+ A+ + ++ P ++A L L
Sbjct: 477 LEH--NQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLL 534
Query: 562 KKQRELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFG 621
+ + + +S+ N LPY+EK+EFPR L FGK LGAGAFG
Sbjct: 535 LLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFG 594
Query: 622 VVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACT 681
V +A A G+ + VAVKM+K TA ++L SELKIM HLG+H NIVNLLGACT
Sbjct: 595 KVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKESLMSELKIMSHLGQHENIVNLLGACT 654
Query: 682 KHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDNAEKNLGKINKGFLNSVGTTGTH 741
++VI EYC YG++ N++++ E + + G ++ ++
Sbjct: 655 HG---GPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR 711
Query: 742 SDYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGH 801
FSS + D + S S SE + +E +G RPL
Sbjct: 712 DSGFSS---QGVDTYVEMRPVSTSSNDSFSEQDLDKE-----DG---------RPLELRD 754
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
LL ++ Q+A+GM +LA++ +H D+AARNVLL + +V KI DFGLAR + N+ Y K N
Sbjct: 755 LLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGN 814
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNI-SPTDLLRWLSDGNR 920
+ LPVKW+A E + D +++ QSDVWSYGI+LWE+FSL PYP I + + + DG +
Sbjct: 815 ARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQ 874
Query: 921 LEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNR-YVDL 971
+ +P FA +Y++M CW +PT RP+F ++ L +++ R R Y +L
Sbjct: 875 MAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNL 926
Score = 50.0 bits (114), Expect = 5e-05
Identities = 53/234 (22%), Positives = 94/234 (40%), Gaps = 20/234 (8%)
Query: 150 YQNITIRNATK---KHNGVYTCLLTNTCGEEKDEFRKIFLEKPFLSLRDLAKGKLMGNAN 206
YQ + N + +H G Y+C+ +N G+ +E +L+L
Sbjct: 257 YQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVG 316
Query: 207 KSINIVIEIEAYPPVER---THFLKNDKYLPSNDLKYNVTT--LANGDPKLRINDLKLTD 261
+ +N+ + +EAYP ++ T+ + P L NVTT L + LK ++
Sbjct: 317 EGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLA-NVTTKDTYRHTFTLSLPRLKPSE 375
Query: 262 IANYTLVAENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRLENSEMNFACKVTGYPLPDVT 321
Y+ +A N + T +L + PE ++ I N C +GYP P+VT
Sbjct: 376 AGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFI-----NGSGTLLCAASGYPQPNVT 430
Query: 322 WIFSN------DEEHELSSTKSEQESLYAKTDYLKISVQASGVITCNAHNSKGE 369
W+ + DE L + ++ + K++VQ+ + HN E
Sbjct: 431 WLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYE 484
>AL591024-3|CAH70634.1| 996|Homo sapiens fms-related tyrosine
kinase 3 protein.
Length = 996
Score = 257 bits (629), Expect = 2e-67
Identities = 158/385 (41%), Positives = 217/385 (56%), Gaps = 21/385 (5%)
Query: 598 YDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKAL 657
YD K+EFPRE L FGK LG+GAFG V A A GI V+ VAVKM+K AD+ +AL
Sbjct: 599 YDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREAL 658
Query: 658 ASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLT 717
SELK+M LG H NIVNLLGACT + +I EYC YG++ NY++ RE F T
Sbjct: 659 MSELKMMTQLGSHENIVNLLGACT---LSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWT 715
Query: 718 DNAEKNLGKINKGFLNSVGTTGTHSDYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQ 777
+ +++ F + ++ S D+D GNS S E I+
Sbjct: 716 EIFKEHNFSFYPTFQSHPNSSMPGSREVQIH--PDSDQISGLHGNSFHS-----EDEIEY 768
Query: 778 EWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDN 837
E Q + E E LT LL +A+Q+A+GME+L + +H DLAARNVL+
Sbjct: 769 ENQKRLE-----EEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGK 823
Query: 838 VVKICDFGLARSMYNNEEYQKKEN---SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWE 894
VVKICDFGLAR + ++ Y + N + LPVKW+A E + + I++ +SDVWSYGI+LWE
Sbjct: 824 VVKICDFGLARDIMSDSNYVVRGNVRLARLPVKWMAPESLFEGIYTIKSDVWSYGILLWE 883
Query: 895 MFSLAKTPYPNISPTD--LLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTEL 952
+FSL PYP I P D + + +G ++++P +A + +Y +M CW RPSF L
Sbjct: 884 IFSLGVNPYPGI-PVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 942
Query: 953 QEILGNFLEDNERNRYVDLNAPYNE 977
LG L D E Y +++ +E
Sbjct: 943 TSFLGCQLADAEEAMYQNVDGRVSE 967
>AL445262-1|CAI17231.1| 996|Homo sapiens fms-related tyrosine
kinase 3 protein.
Length = 996
Score = 257 bits (629), Expect = 2e-67
Identities = 158/385 (41%), Positives = 217/385 (56%), Gaps = 21/385 (5%)
Query: 598 YDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKAL 657
YD K+EFPRE L FGK LG+GAFG V A A GI V+ VAVKM+K AD+ +AL
Sbjct: 599 YDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREAL 658
Query: 658 ASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLT 717
SELK+M LG H NIVNLLGACT + +I EYC YG++ NY++ RE F T
Sbjct: 659 MSELKMMTQLGSHENIVNLLGACT---LSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWT 715
Query: 718 DNAEKNLGKINKGFLNSVGTTGTHSDYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQ 777
+ +++ F + ++ S D+D GNS S E I+
Sbjct: 716 EIFKEHNFSFYPTFQSHPNSSMPGSREVQIH--PDSDQISGLHGNSFHS-----EDEIEY 768
Query: 778 EWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDN 837
E Q + E E LT LL +A+Q+A+GME+L + +H DLAARNVL+
Sbjct: 769 ENQKRLE-----EEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGK 823
Query: 838 VVKICDFGLARSMYNNEEYQKKEN---SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWE 894
VVKICDFGLAR + ++ Y + N + LPVKW+A E + + I++ +SDVWSYGI+LWE
Sbjct: 824 VVKICDFGLARDIMSDSNYVVRGNVRLARLPVKWMAPESLFEGIYTIKSDVWSYGILLWE 883
Query: 895 MFSLAKTPYPNISPTD--LLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTEL 952
+FSL PYP I P D + + +G ++++P +A + +Y +M CW RPSF L
Sbjct: 884 IFSLGVNPYPGI-PVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 942
Query: 953 QEILGNFLEDNERNRYVDLNAPYNE 977
LG L D E Y +++ +E
Sbjct: 943 TSFLGCQLADAEEAMYQNVDGRVSE 967
>AL356915-1|CAI12447.1| 996|Homo sapiens fms-related tyrosine
kinase 3 protein.
Length = 996
Score = 257 bits (629), Expect = 2e-67
Identities = 158/385 (41%), Positives = 217/385 (56%), Gaps = 21/385 (5%)
Query: 598 YDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKAL 657
YD K+EFPRE L FGK LG+GAFG V A A GI V+ VAVKM+K AD+ +AL
Sbjct: 599 YDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREAL 658
Query: 658 ASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLT 717
SELK+M LG H NIVNLLGACT + +I EYC YG++ NY++ RE F T
Sbjct: 659 MSELKMMTQLGSHENIVNLLGACT---LSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWT 715
Query: 718 DNAEKNLGKINKGFLNSVGTTGTHSDYFSSGNTKDTDHSLLYSGNSKRSGRKVSEGYIQQ 777
+ +++ F + ++ S D+D GNS S E I+
Sbjct: 716 EIFKEHNFSFYPTFQSHPNSSMPGSREVQIH--PDSDQISGLHGNSFHS-----EDEIEY 768
Query: 778 EWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDN 837
E Q + E E LT LL +A+Q+A+GME+L + +H DLAARNVL+
Sbjct: 769 ENQKRLE-----EEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGK 823
Query: 838 VVKICDFGLARSMYNNEEYQKKEN---SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWE 894
VVKICDFGLAR + ++ Y + N + LPVKW+A E + + I++ +SDVWSYGI+LWE
Sbjct: 824 VVKICDFGLARDIMSDSNYVVRGNVRLARLPVKWMAPESLFEGIYTIKSDVWSYGILLWE 883
Query: 895 MFSLAKTPYPNISPTD--LLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTEL 952
+FSL PYP I P D + + +G ++++P +A + +Y +M CW RPSF L
Sbjct: 884 IFSLGVNPYPGI-PVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 942
Query: 953 QEILGNFLEDNERNRYVDLNAPYNE 977
LG L D E Y +++ +E
Sbjct: 943 TSFLGCQLADAEEAMYQNVDGRVSE 967
>M64347-1|AAA58470.1| 731|Homo sapiens fgflr protein.
Length = 731
Score = 204 bits (497), Expect = 2e-51
Identities = 92/194 (47%), Positives = 133/194 (68%), Gaps = 2/194 (1%)
Query: 786 DYIYE-CHQPRP-LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
DY ++ C P LT L+ A+Q+ARGMEYLA++K +H DLAARNVL+ +DNV+KI D
Sbjct: 501 DYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIAD 560
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR ++N + Y+K N LPVKW+A E + DR+++ QSDVWS+G++LWE+F+L +PY
Sbjct: 561 FGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPY 620
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P I +L + L +G+R++KP LY +M CWH P+ RP+F +L E L L
Sbjct: 621 PGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVT 680
Query: 964 ERNRYVDLNAPYNE 977
+ Y+DL+AP+ +
Sbjct: 681 STDEYLDLSAPFEQ 694
Score = 95.9 bits (228), Expect = 7e-19
Identities = 55/128 (42%), Positives = 73/128 (57%), Gaps = 5/128 (3%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPV--AVKMVKRTADNMY 653
LP D K+E R +LT GK LG G FG V AEA GI PV AVKM+K A +
Sbjct: 384 LPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKD 443
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFI 713
+ L SE+++M +GKH NI+NLLGACT+ L V+VEY GN+ +++ R +
Sbjct: 444 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---GGPLYVLVEYAAKGNLREFLRARRPPGL 500
Query: 714 DQLTDNAE 721
D D +
Sbjct: 501 DYSFDTCK 508
Score = 38.3 bits (85), Expect = 0.16
Identities = 26/99 (26%), Positives = 44/99 (44%), Gaps = 9/99 (9%)
Query: 86 KKPPKPKVAGG---HKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVE------VS 136
+ P +P + G ++ + G HC+V +D + +W EV V V+
Sbjct: 173 RSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVT 232
Query: 137 VVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCG 175
V+KT T + +++ N T + G YTCL N+ G
Sbjct: 233 VLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIG 271
Score = 35.5 bits (78), Expect = 1.1
Identities = 21/87 (24%), Positives = 38/87 (43%), Gaps = 4/87 (4%)
Query: 451 SIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIY 510
+++ C A G P P+I W K+ +++ + H + +E++ D G Y
Sbjct: 96 TVRFRCPAAGNPTPSISWLKNGREFRGE--HRIGGIKLRHQ--QWSLVMESVVPSDRGNY 151
Query: 511 ECVALNNASELRRAYTLVLKAEKSYTP 537
CV N +R+ YTL + + P
Sbjct: 152 TCVVENKFGSIRQTYTLDVLERSPHRP 178
Score = 33.1 bits (72), Expect = 5.9
Identities = 25/100 (25%), Positives = 46/100 (46%), Gaps = 9/100 (9%)
Query: 443 DEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSG--YKLFVDIVNHTIVNST---- 496
++ A+ G ++ HC+ +P I W K E+ + G +V ++ N+T
Sbjct: 187 NQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKEL 246
Query: 497 --FEIENMQEKDNGIYECVALNNAS-ELRRAYTLVLKAEK 533
+ N+ +D G Y C+A N+ A+ +VL AE+
Sbjct: 247 EVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEE 286
>M58051-1|AAA52450.1| 806|Homo sapiens fibroblast growth factor
receptor protein.
Length = 806
Score = 204 bits (497), Expect = 2e-51
Identities = 92/194 (47%), Positives = 133/194 (68%), Gaps = 2/194 (1%)
Query: 786 DYIYE-CHQPRP-LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
DY ++ C P LT L+ A+Q+ARGMEYLA++K +H DLAARNVL+ +DNV+KI D
Sbjct: 576 DYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIAD 635
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR ++N + Y+K N LPVKW+A E + DR+++ QSDVWS+G++LWE+F+L +PY
Sbjct: 636 FGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPY 695
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P I +L + L +G+R++KP LY +M CWH P+ RP+F +L E L L
Sbjct: 696 PGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVT 755
Query: 964 ERNRYVDLNAPYNE 977
+ Y+DL+AP+ +
Sbjct: 756 STDEYLDLSAPFEQ 769
Score = 95.9 bits (228), Expect = 7e-19
Identities = 55/128 (42%), Positives = 73/128 (57%), Gaps = 5/128 (3%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPV--AVKMVKRTADNMY 653
LP D K+E R +LT GK LG G FG V AEA GI PV AVKM+K A +
Sbjct: 459 LPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKD 518
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFI 713
+ L SE+++M +GKH NI+NLLGACT+ L V+VEY GN+ +++ R +
Sbjct: 519 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---GGPLYVLVEYAAKGNLREFLRARRPPGL 575
Query: 714 DQLTDNAE 721
D D +
Sbjct: 576 DYSFDTCK 583
Score = 38.3 bits (85), Expect = 0.16
Identities = 26/99 (26%), Positives = 44/99 (44%), Gaps = 9/99 (9%)
Query: 86 KKPPKPKVAGG---HKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVE------VS 136
+ P +P + G ++ + G HC+V +D + +W EV V V+
Sbjct: 248 RSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVT 307
Query: 137 VVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCG 175
V+KT T + +++ N T + G YTCL N+ G
Sbjct: 308 VLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIG 346
Score = 35.5 bits (78), Expect = 1.1
Identities = 21/87 (24%), Positives = 38/87 (43%), Gaps = 4/87 (4%)
Query: 451 SIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIY 510
+++ C A G P P+I W K+ +++ + H + +E++ D G Y
Sbjct: 171 TVRFRCPAAGNPTPSISWLKNGREFRGE--HRIGGIKLRHQ--QWSLVMESVVPSDRGNY 226
Query: 511 ECVALNNASELRRAYTLVLKAEKSYTP 537
CV N +R+ YTL + + P
Sbjct: 227 TCVVENKFGSIRQTYTLDVLERSPHRP 253
Score = 33.1 bits (72), Expect = 5.9
Identities = 25/100 (25%), Positives = 46/100 (46%), Gaps = 9/100 (9%)
Query: 443 DEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSG--YKLFVDIVNHTIVNST---- 496
++ A+ G ++ HC+ +P I W K E+ + G +V ++ N+T
Sbjct: 262 NQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKEL 321
Query: 497 --FEIENMQEKDNGIYECVALNNAS-ELRRAYTLVLKAEK 533
+ N+ +D G Y C+A N+ A+ +VL AE+
Sbjct: 322 EVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEE 361
>BC128610-1|AAI28611.1| 480|Homo sapiens FGFR3 protein protein.
Length = 480
Score = 204 bits (497), Expect = 2e-51
Identities = 92/194 (47%), Positives = 133/194 (68%), Gaps = 2/194 (1%)
Query: 786 DYIYE-CHQPRP-LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
DY ++ C P LT L+ A+Q+ARGMEYLA++K +H DLAARNVL+ +DNV+KI D
Sbjct: 250 DYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIAD 309
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR ++N + Y+K N LPVKW+A E + DR+++ QSDVWS+G++LWE+F+L +PY
Sbjct: 310 FGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPY 369
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P I +L + L +G+R++KP LY +M CWH P+ RP+F +L E L L
Sbjct: 370 PGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVT 429
Query: 964 ERNRYVDLNAPYNE 977
+ Y+DL+AP+ +
Sbjct: 430 STDEYLDLSAPFEQ 443
Score = 95.9 bits (228), Expect = 7e-19
Identities = 55/128 (42%), Positives = 73/128 (57%), Gaps = 5/128 (3%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPV--AVKMVKRTADNMY 653
LP D K+E R +LT GK LG G FG V AEA GI PV AVKM+K A +
Sbjct: 133 LPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKD 192
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFI 713
+ L SE+++M +GKH NI+NLLGACT+ L V+VEY GN+ +++ R +
Sbjct: 193 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---GGPLYVLVEYAAKGNLREFLRARRPPGL 249
Query: 714 DQLTDNAE 721
D D +
Sbjct: 250 DYSFDTCK 257
>BC121175-1|AAI21176.1| 480|Homo sapiens FGFR3 protein protein.
Length = 480
Score = 204 bits (497), Expect = 2e-51
Identities = 92/194 (47%), Positives = 133/194 (68%), Gaps = 2/194 (1%)
Query: 786 DYIYE-CHQPRP-LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
DY ++ C P LT L+ A+Q+ARGMEYLA++K +H DLAARNVL+ +DNV+KI D
Sbjct: 250 DYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIAD 309
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR ++N + Y+K N LPVKW+A E + DR+++ QSDVWS+G++LWE+F+L +PY
Sbjct: 310 FGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPY 369
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P I +L + L +G+R++KP LY +M CWH P+ RP+F +L E L L
Sbjct: 370 PGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVT 429
Query: 964 ERNRYVDLNAPYNE 977
+ Y+DL+AP+ +
Sbjct: 430 STDEYLDLSAPFEQ 443
Score = 95.9 bits (228), Expect = 7e-19
Identities = 55/128 (42%), Positives = 73/128 (57%), Gaps = 5/128 (3%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPV--AVKMVKRTADNMY 653
LP D K+E R +LT GK LG G FG V AEA GI PV AVKM+K A +
Sbjct: 133 LPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKD 192
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFI 713
+ L SE+++M +GKH NI+NLLGACT+ L V+VEY GN+ +++ R +
Sbjct: 193 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---GGPLYVLVEYAAKGNLREFLRARRPPGL 249
Query: 714 DQLTDNAE 721
D D +
Sbjct: 250 DYSFDTCK 257
>AY768549-1|AAU89726.1| 806|Homo sapiens fibroblast growth factor
receptor 3 (achondroplasia, thanatophoric dwarfism)
protein.
Length = 806
Score = 204 bits (497), Expect = 2e-51
Identities = 92/194 (47%), Positives = 133/194 (68%), Gaps = 2/194 (1%)
Query: 786 DYIYE-CHQPRP-LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
DY ++ C P LT L+ A+Q+ARGMEYLA++K +H DLAARNVL+ +DNV+KI D
Sbjct: 576 DYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIAD 635
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR ++N + Y+K N LPVKW+A E + DR+++ QSDVWS+G++LWE+F+L +PY
Sbjct: 636 FGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPY 695
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P I +L + L +G+R++KP LY +M CWH P+ RP+F +L E L L
Sbjct: 696 PGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVT 755
Query: 964 ERNRYVDLNAPYNE 977
+ Y+DL+AP+ +
Sbjct: 756 STDEYLDLSAPFEQ 769
Score = 95.9 bits (228), Expect = 7e-19
Identities = 55/128 (42%), Positives = 73/128 (57%), Gaps = 5/128 (3%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPV--AVKMVKRTADNMY 653
LP D K+E R +LT GK LG G FG V AEA GI PV AVKM+K A +
Sbjct: 459 LPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKD 518
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFI 713
+ L SE+++M +GKH NI+NLLGACT+ L V+VEY GN+ +++ R +
Sbjct: 519 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---GGPLYVLVEYAAKGNLREFLRARRPPGL 575
Query: 714 DQLTDNAE 721
D D +
Sbjct: 576 DYSFDTCK 583
Score = 38.3 bits (85), Expect = 0.16
Identities = 26/99 (26%), Positives = 44/99 (44%), Gaps = 9/99 (9%)
Query: 86 KKPPKPKVAGG---HKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVE------VS 136
+ P +P + G ++ + G HC+V +D + +W EV V V+
Sbjct: 248 RSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVT 307
Query: 137 VVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCG 175
V+KT T + +++ N T + G YTCL N+ G
Sbjct: 308 VLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIG 346
Score = 35.5 bits (78), Expect = 1.1
Identities = 21/87 (24%), Positives = 38/87 (43%), Gaps = 4/87 (4%)
Query: 451 SIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIY 510
+++ C A G P P+I W K+ +++ + H + +E++ D G Y
Sbjct: 171 TVRFRCPAAGNPTPSISWLKNGREFRGE--HRIGGIKLRHQ--QWSLVMESVVPSDRGNY 226
Query: 511 ECVALNNASELRRAYTLVLKAEKSYTP 537
CV N +R+ YTL + + P
Sbjct: 227 TCVVENKFGSIRQTYTLDVLERSPHRP 253
Score = 33.1 bits (72), Expect = 5.9
Identities = 25/100 (25%), Positives = 46/100 (46%), Gaps = 9/100 (9%)
Query: 443 DEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSG--YKLFVDIVNHTIVNST---- 496
++ A+ G ++ HC+ +P I W K E+ + G +V ++ N+T
Sbjct: 262 NQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKEL 321
Query: 497 --FEIENMQEKDNGIYECVALNNAS-ELRRAYTLVLKAEK 533
+ N+ +D G Y C+A N+ A+ +VL AE+
Sbjct: 322 EVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEE 361
>AF487554-2|AAM22078.1| 769|Homo sapiens fibroblast growth factor
receptor 3 protein.
Length = 769
Score = 204 bits (497), Expect = 2e-51
Identities = 92/194 (47%), Positives = 133/194 (68%), Gaps = 2/194 (1%)
Query: 786 DYIYE-CHQPRP-LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
DY ++ C P LT L+ A+Q+ARGMEYLA++K +H DLAARNVL+ +DNV+KI D
Sbjct: 539 DYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIAD 598
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR ++N + Y+K N LPVKW+A E + DR+++ QSDVWS+G++LWE+F+L +PY
Sbjct: 599 FGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPY 658
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P I +L + L +G+R++KP LY +M CWH P+ RP+F +L E L L
Sbjct: 659 PGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVT 718
Query: 964 ERNRYVDLNAPYNE 977
+ Y+DL+AP+ +
Sbjct: 719 STDEYLDLSAPFEQ 732
Score = 95.9 bits (228), Expect = 7e-19
Identities = 55/128 (42%), Positives = 73/128 (57%), Gaps = 5/128 (3%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPV--AVKMVKRTADNMY 653
LP D K+E R +LT GK LG G FG V AEA GI PV AVKM+K A +
Sbjct: 422 LPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKD 481
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFI 713
+ L SE+++M +GKH NI+NLLGACT+ L V+VEY GN+ +++ R +
Sbjct: 482 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---GGPLYVLVEYAAKGNLREFLRARRPPGL 538
Query: 714 DQLTDNAE 721
D D +
Sbjct: 539 DYSFDTCK 546
Score = 38.3 bits (85), Expect = 0.16
Identities = 26/99 (26%), Positives = 44/99 (44%), Gaps = 9/99 (9%)
Query: 86 KKPPKPKVAGG---HKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVE------VS 136
+ P +P + G ++ + G HC+V +D + +W EV V V+
Sbjct: 211 RSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVT 270
Query: 137 VVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCG 175
V+KT T + +++ N T + G YTCL N+ G
Sbjct: 271 VLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIG 309
Score = 35.5 bits (78), Expect = 1.1
Identities = 21/87 (24%), Positives = 38/87 (43%), Gaps = 4/87 (4%)
Query: 451 SIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIY 510
+++ C A G P P+I W K+ +++ + H + +E++ D G Y
Sbjct: 134 TVRFRCPAAGNPTPSISWLKNGREFRGE--HRIGGIKLRHQ--QWSLVMESVVPSDRGNY 189
Query: 511 ECVALNNASELRRAYTLVLKAEKSYTP 537
CV N +R+ YTL + + P
Sbjct: 190 TCVVENKFGSIRQTYTLDVLERSPHRP 216
Score = 33.1 bits (72), Expect = 5.9
Identities = 25/100 (25%), Positives = 46/100 (46%), Gaps = 9/100 (9%)
Query: 443 DEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSG--YKLFVDIVNHTIVNST---- 496
++ A+ G ++ HC+ +P I W K E+ + G +V ++ N+T
Sbjct: 225 NQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKEL 284
Query: 497 --FEIENMQEKDNGIYECVALNNAS-ELRRAYTLVLKAEK 533
+ N+ +D G Y C+A N+ A+ +VL AE+
Sbjct: 285 EVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEE 324
>AF487554-1|AAM22079.1| 771|Homo sapiens fibroblast growth factor
receptor 3 protein.
Length = 771
Score = 204 bits (497), Expect = 2e-51
Identities = 92/194 (47%), Positives = 133/194 (68%), Gaps = 2/194 (1%)
Query: 786 DYIYE-CHQPRP-LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
DY ++ C P LT L+ A+Q+ARGMEYLA++K +H DLAARNVL+ +DNV+KI D
Sbjct: 541 DYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIAD 600
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR ++N + Y+K N LPVKW+A E + DR+++ QSDVWS+G++LWE+F+L +PY
Sbjct: 601 FGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPY 660
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P I +L + L +G+R++KP LY +M CWH P+ RP+F +L E L L
Sbjct: 661 PGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVT 720
Query: 964 ERNRYVDLNAPYNE 977
+ Y+DL+AP+ +
Sbjct: 721 STDEYLDLSAPFEQ 734
Score = 95.9 bits (228), Expect = 7e-19
Identities = 55/128 (42%), Positives = 73/128 (57%), Gaps = 5/128 (3%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPV--AVKMVKRTADNMY 653
LP D K+E R +LT GK LG G FG V AEA GI PV AVKM+K A +
Sbjct: 424 LPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKD 483
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFI 713
+ L SE+++M +GKH NI+NLLGACT+ L V+VEY GN+ +++ R +
Sbjct: 484 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---GGPLYVLVEYAAKGNLREFLRARRPPGL 540
Query: 714 DQLTDNAE 721
D D +
Sbjct: 541 DYSFDTCK 548
Score = 35.5 bits (78), Expect = 1.1
Identities = 21/87 (24%), Positives = 38/87 (43%), Gaps = 4/87 (4%)
Query: 451 SIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIY 510
+++ C A G P P+I W K+ +++ + H + +E++ D G Y
Sbjct: 134 TVRFRCPAAGNPTPSISWLKNGREFRGE--HRIGGIKLRHQ--QWSLVMESVVPSDRGNY 189
Query: 511 ECVALNNASELRRAYTLVLKAEKSYTP 537
CV N +R+ YTL + + P
Sbjct: 190 TCVVENKFGSIRQTYTLDVLERSPHRP 216
Score = 35.1 bits (77), Expect = 1.5
Identities = 25/120 (20%), Positives = 48/120 (40%), Gaps = 7/120 (5%)
Query: 443 DEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSG--YKLFVDIVNHTIVNST---- 496
++ A+ G ++ HC+ +P I W K E+ + G +V ++ I S
Sbjct: 225 NQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADV 284
Query: 497 -FEIENMQEKDNGIYECVALNNASELRRAYTLVLKAEKSYTPYXXXXXXXXXXXXGMVAY 555
+ N+ E+D G Y C A N +A+ L + ++ G+++Y
Sbjct: 285 RLRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGILSY 344
>AF245114-1|AAF63380.1| 694|Homo sapiens fibroblast growth factor
receptor 3 protein.
Length = 694
Score = 204 bits (497), Expect = 2e-51
Identities = 92/194 (47%), Positives = 133/194 (68%), Gaps = 2/194 (1%)
Query: 786 DYIYE-CHQPRP-LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
DY ++ C P LT L+ A+Q+ARGMEYLA++K +H DLAARNVL+ +DNV+KI D
Sbjct: 464 DYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIAD 523
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR ++N + Y+K N LPVKW+A E + DR+++ QSDVWS+G++LWE+F+L +PY
Sbjct: 524 FGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPY 583
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P I +L + L +G+R++KP LY +M CWH P+ RP+F +L E L L
Sbjct: 584 PGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVT 643
Query: 964 ERNRYVDLNAPYNE 977
+ Y+DL+AP+ +
Sbjct: 644 STDEYLDLSAPFEQ 657
Score = 95.9 bits (228), Expect = 7e-19
Identities = 55/128 (42%), Positives = 73/128 (57%), Gaps = 5/128 (3%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPV--AVKMVKRTADNMY 653
LP D K+E R +LT GK LG G FG V AEA GI PV AVKM+K A +
Sbjct: 347 LPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKD 406
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFI 713
+ L SE+++M +GKH NI+NLLGACT+ L V+VEY GN+ +++ R +
Sbjct: 407 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---GGPLYVLVEYAAKGNLREFLRARRPPGL 463
Query: 714 DQLTDNAE 721
D D +
Sbjct: 464 DYSFDTCK 471
Score = 35.5 bits (78), Expect = 1.1
Identities = 21/87 (24%), Positives = 38/87 (43%), Gaps = 4/87 (4%)
Query: 451 SIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIY 510
+++ C A G P P+I W K+ +++ + H + +E++ D G Y
Sbjct: 171 TVRFRCPAAGNPTPSISWLKNGREFRGE--HRIGGIKLRHQ--QWSLVMESVVPSDRGNY 226
Query: 511 ECVALNNASELRRAYTLVLKAEKSYTP 537
CV N +R+ YTL + + P
Sbjct: 227 TCVVENKFGSIRQTYTLDVLERSPHRP 253
Score = 32.7 bits (71), Expect = 7.9
Identities = 27/108 (25%), Positives = 53/108 (49%), Gaps = 11/108 (10%)
Query: 260 TDIANYTLVAENKY--LTKNYTVDLRVFTKPEAKLLNNRIIKR---LENSEMNFACKVTG 314
+D NYT V ENK+ + + YT+D+ + P +L + + S++ F CKV
Sbjct: 221 SDRGNYTCVVENKFGSIRQTYTLDV-LERSPHRPILQAGLPANQTAVLGSDVEFHCKVYS 279
Query: 315 YPLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYLKISVQASGVITCN 362
P + W+ + E++ +K + T LK+S++++ ++ N
Sbjct: 280 DAQPHIQWL----KHVEVNGSKVGPDGTPYVT-VLKVSLESNASMSSN 322
>Y00665-1|CAA68679.1| 622|Homo sapiens tyrosine kinase protein.
Length = 622
Score = 198 bits (483), Expect = 9e-50
Identities = 92/222 (41%), Positives = 142/222 (63%), Gaps = 5/222 (2%)
Query: 786 DYIYE-CHQPRP-LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y H P L+S L+ A+Q+ARGMEYLA++K +H DLAARNVL+ +DNV+KI D
Sbjct: 382 EYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIAD 441
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR +++ + Y+K N LPVKW+A E + DRI++ QSDVWS+G++LWE+F+L +PY
Sbjct: 442 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 501
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P + +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L +
Sbjct: 502 PGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALT 561
Query: 964 ERNRYVDLNAPYNEMNAELMTGEDYLAMVCAPDYNNIVTPSP 1005
Y+DL+ P ++ + D + C+ +++ + P
Sbjct: 562 SNQEYLDLSMPLDQYSPSF---PDTRSSTCSSGEDSVFSHEP 600
Score = 97.5 bits (232), Expect = 2e-19
Identities = 54/116 (46%), Positives = 70/116 (60%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVT--TPVAVKMVKRTADNMY 653
LP D ++E PR++L GK LG G FG V AEA G+ + T VAVKM+K A
Sbjct: 265 LPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD 324
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y+Q R
Sbjct: 325 LSDLISEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLQARR 377
Score = 36.3 bits (80), Expect = 0.64
Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 4/68 (5%)
Query: 260 TDIANYTLVAENKYLTKNYTVDLRVFTK-PEAKLLNNRIIKRLE---NSEMNFACKVTGY 315
+D NYT + EN+Y + N+T L V + P +L + S + F CKV
Sbjct: 23 SDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 82
Query: 316 PLPDVTWI 323
P P + W+
Sbjct: 83 PQPHIQWL 90
Score = 32.7 bits (71), Expect = 7.9
Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 9/99 (9%)
Query: 86 KKPPKPKVAGG---HKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVE------VS 136
+ P +P + G +K G C+V +D + +W EV + V
Sbjct: 50 RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQ 109
Query: 137 VVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCG 175
++KT T + + +RN + + G YTCL N+ G
Sbjct: 110 ILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG 148
>X66945-1|CAA47375.1| 822|Homo sapiens fibroblast growth factor
receptor protein.
Length = 822
Score = 198 bits (483), Expect = 9e-50
Identities = 92/222 (41%), Positives = 142/222 (63%), Gaps = 5/222 (2%)
Query: 786 DYIYE-CHQPRP-LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y H P L+S L+ A+Q+ARGMEYLA++K +H DLAARNVL+ +DNV+KI D
Sbjct: 582 EYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIAD 641
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR +++ + Y+K N LPVKW+A E + DRI++ QSDVWS+G++LWE+F+L +PY
Sbjct: 642 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 701
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P + +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L +
Sbjct: 702 PGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALT 761
Query: 964 ERNRYVDLNAPYNEMNAELMTGEDYLAMVCAPDYNNIVTPSP 1005
Y+DL+ P ++ + D + C+ +++ + P
Sbjct: 762 SNQEYLDLSMPLDQYSPSF---PDTRSSTCSSGEDSVFSHEP 800
Score = 97.5 bits (232), Expect = 2e-19
Identities = 54/116 (46%), Positives = 70/116 (60%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVT--TPVAVKMVKRTADNMY 653
LP D ++E PR++L GK LG G FG V AEA G+ + T VAVKM+K A
Sbjct: 465 LPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD 524
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y+Q R
Sbjct: 525 LSDLISEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLQARR 577
Score = 36.3 bits (80), Expect = 0.64
Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 4/68 (5%)
Query: 260 TDIANYTLVAENKYLTKNYTVDLRVFTK-PEAKLLNNRIIKRLE---NSEMNFACKVTGY 315
+D NYT + EN+Y + N+T L V + P +L + S + F CKV
Sbjct: 223 SDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 282
Query: 316 PLPDVTWI 323
P P + W+
Sbjct: 283 PQPHIQWL 290
Score = 34.7 bits (76), Expect = 1.9
Identities = 20/90 (22%), Positives = 38/90 (42%), Gaps = 8/90 (8%)
Query: 450 RSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDN 507
++++ C + G P PT+ W K N +K I + + +T+ I +++ D
Sbjct: 172 KTVKFKCPSSGTPNPTLRWLK------NGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 225
Query: 508 GIYECVALNNASELRRAYTLVLKAEKSYTP 537
G Y C+ N + Y L + + P
Sbjct: 226 GNYTCIVENEYGSINHTYQLDVVERSPHRP 255
Score = 32.7 bits (71), Expect = 7.9
Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 9/99 (9%)
Query: 86 KKPPKPKVAGG---HKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVE------VS 136
+ P +P + G +K G C+V +D + +W EV + V
Sbjct: 250 RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQ 309
Query: 137 VVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCG 175
++KT T + + +RN + + G YTCL N+ G
Sbjct: 310 ILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG 348
>X57122-1|CAA40404.1| 731|Homo sapiens Fibroblast Growth Factor
Receptor, 2 Ig-Domain Form protein.
Length = 731
Score = 198 bits (483), Expect = 9e-50
Identities = 92/222 (41%), Positives = 142/222 (63%), Gaps = 5/222 (2%)
Query: 786 DYIYE-CHQPRP-LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y H P L+S L+ A+Q+ARGMEYLA++K +H DLAARNVL+ +DNV+KI D
Sbjct: 491 EYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIAD 550
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR +++ + Y+K N LPVKW+A E + DRI++ QSDVWS+G++LWE+F+L +PY
Sbjct: 551 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 610
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P + +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L +
Sbjct: 611 PGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALT 670
Query: 964 ERNRYVDLNAPYNEMNAELMTGEDYLAMVCAPDYNNIVTPSP 1005
Y+DL+ P ++ + D + C+ +++ + P
Sbjct: 671 SNQEYLDLSMPLDQYSPSF---PDTRSSTCSSGEDSVFSHEP 709
Score = 97.5 bits (232), Expect = 2e-19
Identities = 54/116 (46%), Positives = 70/116 (60%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVT--TPVAVKMVKRTADNMY 653
LP D ++E PR++L GK LG G FG V AEA G+ + T VAVKM+K A
Sbjct: 374 LPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD 433
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y+Q R
Sbjct: 434 LSDLISEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLQARR 486
Score = 36.3 bits (80), Expect = 0.64
Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 4/68 (5%)
Query: 260 TDIANYTLVAENKYLTKNYTVDLRVFTK-PEAKLLNNRIIKRLE---NSEMNFACKVTGY 315
+D NYT + EN+Y + N+T L V + P +L + S + F CKV
Sbjct: 132 SDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 191
Query: 316 PLPDVTWI 323
P P + W+
Sbjct: 192 PQPHIQWL 199
Score = 34.7 bits (76), Expect = 1.9
Identities = 20/90 (22%), Positives = 38/90 (42%), Gaps = 8/90 (8%)
Query: 450 RSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDN 507
++++ C + G P PT+ W K N +K I + + +T+ I +++ D
Sbjct: 81 KTVKFKCPSSGTPNPTLRWLK------NGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 134
Query: 508 GIYECVALNNASELRRAYTLVLKAEKSYTP 537
G Y C+ N + Y L + + P
Sbjct: 135 GNYTCIVENEYGSINHTYQLDVVERSPHRP 164
Score = 32.7 bits (71), Expect = 7.9
Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 9/99 (9%)
Query: 86 KKPPKPKVAGG---HKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVE------VS 136
+ P +P + G +K G C+V +D + +W EV + V
Sbjct: 159 RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQ 218
Query: 137 VVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCG 175
++KT T + + +RN + + G YTCL N+ G
Sbjct: 219 ILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG 257
>X57121-1|CAA40403.1| 822|Homo sapiens Fibroblast Growth Factor
Receptor, 3-Ig Domain+2orm protein.
Length = 822
Score = 198 bits (483), Expect = 9e-50
Identities = 92/222 (41%), Positives = 142/222 (63%), Gaps = 5/222 (2%)
Query: 786 DYIYE-CHQPRP-LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y H P L+S L+ A+Q+ARGMEYLA++K +H DLAARNVL+ +DNV+KI D
Sbjct: 582 EYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIAD 641
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR +++ + Y+K N LPVKW+A E + DRI++ QSDVWS+G++LWE+F+L +PY
Sbjct: 642 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 701
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P + +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L +
Sbjct: 702 PGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALT 761
Query: 964 ERNRYVDLNAPYNEMNAELMTGEDYLAMVCAPDYNNIVTPSP 1005
Y+DL+ P ++ + D + C+ +++ + P
Sbjct: 762 SNQEYLDLSMPLDQYSPSF---PDTRSSTCSSGEDSVFSHEP 800
Score = 97.5 bits (232), Expect = 2e-19
Identities = 54/116 (46%), Positives = 70/116 (60%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVT--TPVAVKMVKRTADNMY 653
LP D ++E PR++L GK LG G FG V AEA G+ + T VAVKM+K A
Sbjct: 465 LPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD 524
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y+Q R
Sbjct: 525 LSDLISEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLQARR 577
Score = 36.3 bits (80), Expect = 0.64
Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 4/68 (5%)
Query: 260 TDIANYTLVAENKYLTKNYTVDLRVFTK-PEAKLLNNRIIKRLE---NSEMNFACKVTGY 315
+D NYT + EN+Y + N+T L V + P +L + S + F CKV
Sbjct: 223 SDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 282
Query: 316 PLPDVTWI 323
P P + W+
Sbjct: 283 PQPHIQWL 290
Score = 34.7 bits (76), Expect = 1.9
Identities = 20/90 (22%), Positives = 38/90 (42%), Gaps = 8/90 (8%)
Query: 450 RSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDN 507
++++ C + G P PT+ W K N +K I + + +T+ I +++ D
Sbjct: 172 KTVKFKCPSSGTPNPTLRWLK------NGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 225
Query: 508 GIYECVALNNASELRRAYTLVLKAEKSYTP 537
G Y C+ N + Y L + + P
Sbjct: 226 GNYTCIVENEYGSINHTYQLDVVERSPHRP 255
Score = 32.7 bits (71), Expect = 7.9
Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 9/99 (9%)
Query: 86 KKPPKPKVAGG---HKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVE------VS 136
+ P +P + G +K G C+V +D + +W EV + V
Sbjct: 250 RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQ 309
Query: 137 VVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCG 175
++KT T + + +RN + + G YTCL N+ G
Sbjct: 310 ILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG 348
>X57120-1|CAA40402.1| 820|Homo sapiens Fibroblast Growth Factor
Receptor, 3 Ig-Domain Form protein.
Length = 820
Score = 198 bits (483), Expect = 9e-50
Identities = 92/222 (41%), Positives = 142/222 (63%), Gaps = 5/222 (2%)
Query: 786 DYIYE-CHQPRP-LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y H P L+S L+ A+Q+ARGMEYLA++K +H DLAARNVL+ +DNV+KI D
Sbjct: 580 EYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIAD 639
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR +++ + Y+K N LPVKW+A E + DRI++ QSDVWS+G++LWE+F+L +PY
Sbjct: 640 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 699
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P + +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L +
Sbjct: 700 PGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALT 759
Query: 964 ERNRYVDLNAPYNEMNAELMTGEDYLAMVCAPDYNNIVTPSP 1005
Y+DL+ P ++ + D + C+ +++ + P
Sbjct: 760 SNQEYLDLSMPLDQYSPSF---PDTRSSTCSSGEDSVFSHEP 798
Score = 97.5 bits (232), Expect = 2e-19
Identities = 54/116 (46%), Positives = 70/116 (60%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVT--TPVAVKMVKRTADNMY 653
LP D ++E PR++L GK LG G FG V AEA G+ + T VAVKM+K A
Sbjct: 463 LPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD 522
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y+Q R
Sbjct: 523 LSDLISEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLQARR 575
Score = 36.3 bits (80), Expect = 0.64
Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 4/68 (5%)
Query: 260 TDIANYTLVAENKYLTKNYTVDLRVFTK-PEAKLLNNRIIKRLE---NSEMNFACKVTGY 315
+D NYT + EN+Y + N+T L V + P +L + S + F CKV
Sbjct: 221 SDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 280
Query: 316 PLPDVTWI 323
P P + W+
Sbjct: 281 PQPHIQWL 288
Score = 34.7 bits (76), Expect = 1.9
Identities = 20/90 (22%), Positives = 38/90 (42%), Gaps = 8/90 (8%)
Query: 450 RSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDN 507
++++ C + G P PT+ W K N +K I + + +T+ I +++ D
Sbjct: 170 KTVKFKCPSSGTPNPTLRWLK------NGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 223
Query: 508 GIYECVALNNASELRRAYTLVLKAEKSYTP 537
G Y C+ N + Y L + + P
Sbjct: 224 GNYTCIVENEYGSINHTYQLDVVERSPHRP 253
Score = 32.7 bits (71), Expect = 7.9
Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 9/99 (9%)
Query: 86 KKPPKPKVAGG---HKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVE------VS 136
+ P +P + G +K G C+V +D + +W EV + V
Sbjct: 248 RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQ 307
Query: 137 VVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCG 175
++KT T + + +RN + + G YTCL N+ G
Sbjct: 308 ILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG 346
>X57119-1|CAA40401.1| 733|Homo sapiens Fibroblast Growth Factor
Receptor, 2-Ig Domain+25-1 protein.
Length = 733
Score = 198 bits (483), Expect = 9e-50
Identities = 92/222 (41%), Positives = 142/222 (63%), Gaps = 5/222 (2%)
Query: 786 DYIYE-CHQPRP-LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y H P L+S L+ A+Q+ARGMEYLA++K +H DLAARNVL+ +DNV+KI D
Sbjct: 493 EYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIAD 552
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR +++ + Y+K N LPVKW+A E + DRI++ QSDVWS+G++LWE+F+L +PY
Sbjct: 553 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 612
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P + +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L +
Sbjct: 613 PGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALT 672
Query: 964 ERNRYVDLNAPYNEMNAELMTGEDYLAMVCAPDYNNIVTPSP 1005
Y+DL+ P ++ + D + C+ +++ + P
Sbjct: 673 SNQEYLDLSMPLDQYSPSF---PDTRSSTCSSGEDSVFSHEP 711
Score = 97.5 bits (232), Expect = 2e-19
Identities = 54/116 (46%), Positives = 70/116 (60%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVT--TPVAVKMVKRTADNMY 653
LP D ++E PR++L GK LG G FG V AEA G+ + T VAVKM+K A
Sbjct: 376 LPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD 435
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y+Q R
Sbjct: 436 LSDLISEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLQARR 488
Score = 36.3 bits (80), Expect = 0.64
Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 4/68 (5%)
Query: 260 TDIANYTLVAENKYLTKNYTVDLRVFTK-PEAKLLNNRIIKRLE---NSEMNFACKVTGY 315
+D NYT + EN+Y + N+T L V + P +L + S + F CKV
Sbjct: 134 SDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 193
Query: 316 PLPDVTWI 323
P P + W+
Sbjct: 194 PQPHIQWL 201
Score = 34.7 bits (76), Expect = 1.9
Identities = 20/90 (22%), Positives = 38/90 (42%), Gaps = 8/90 (8%)
Query: 450 RSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDN 507
++++ C + G P PT+ W K N +K I + + +T+ I +++ D
Sbjct: 83 KTVKFKCPSSGTPNPTLRWLK------NGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 136
Query: 508 GIYECVALNNASELRRAYTLVLKAEKSYTP 537
G Y C+ N + Y L + + P
Sbjct: 137 GNYTCIVENEYGSINHTYQLDVVERSPHRP 166
Score = 32.7 bits (71), Expect = 7.9
Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 9/99 (9%)
Query: 86 KKPPKPKVAGG---HKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVE------VS 136
+ P +P + G +K G C+V +D + +W EV + V
Sbjct: 161 RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQ 220
Query: 137 VVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCG 175
++KT T + + +RN + + G YTCL N+ G
Sbjct: 221 ILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG 259
>X52833-1|CAA37015.1| 822|Homo sapiens protein ( Human flg mRNA for
fibroblast growth factor receptor-FLG. ).
Length = 822
Score = 198 bits (483), Expect = 9e-50
Identities = 92/222 (41%), Positives = 142/222 (63%), Gaps = 5/222 (2%)
Query: 786 DYIYE-CHQPRP-LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y H P L+S L+ A+Q+ARGMEYLA++K +H DLAARNVL+ +DNV+KI D
Sbjct: 582 EYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIAD 641
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR +++ + Y+K N LPVKW+A E + DRI++ QSDVWS+G++LWE+F+L +PY
Sbjct: 642 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 701
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P + +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L +
Sbjct: 702 PGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALT 761
Query: 964 ERNRYVDLNAPYNEMNAELMTGEDYLAMVCAPDYNNIVTPSP 1005
Y+DL+ P ++ + D + C+ +++ + P
Sbjct: 762 SNQEYLDLSMPLDQYSPSF---PDTRSSTCSSGEDSVFSHEP 800
Score = 97.5 bits (232), Expect = 2e-19
Identities = 54/116 (46%), Positives = 70/116 (60%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVT--TPVAVKMVKRTADNMY 653
LP D ++E PR++L GK LG G FG V AEA G+ + T VAVKM+K A
Sbjct: 465 LPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD 524
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y+Q R
Sbjct: 525 LSDLISEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLQARR 577
Score = 36.3 bits (80), Expect = 0.64
Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 4/68 (5%)
Query: 260 TDIANYTLVAENKYLTKNYTVDLRVFTK-PEAKLLNNRIIKRLE---NSEMNFACKVTGY 315
+D NYT + EN+Y + N+T L V + P +L + S + F CKV
Sbjct: 223 SDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 282
Query: 316 PLPDVTWI 323
P P + W+
Sbjct: 283 PQPHIQWL 290
Score = 34.7 bits (76), Expect = 1.9
Identities = 20/90 (22%), Positives = 38/90 (42%), Gaps = 8/90 (8%)
Query: 450 RSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDN 507
++++ C + G P PT+ W K N +K I + + +T+ I +++ D
Sbjct: 172 KTVKFKCPSSGTPNPTLRWLK------NGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 225
Query: 508 GIYECVALNNASELRRAYTLVLKAEKSYTP 537
G Y C+ N + Y L + + P
Sbjct: 226 GNYTCIVENEYGSINHTYQLDVVERSPHRP 255
Score = 32.7 bits (71), Expect = 7.9
Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 9/99 (9%)
Query: 86 KKPPKPKVAGG---HKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVE------VS 136
+ P +P + G +K G C+V +D + +W EV + V
Sbjct: 250 RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQ 309
Query: 137 VVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCG 175
++KT T + + +RN + + G YTCL N+ G
Sbjct: 310 ILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG 348
>X51803-1|CAA36101.1| 822|Homo sapiens protein ( Human mRNA for
fibroblast growth factor (FGF) receptor. ).
Length = 822
Score = 198 bits (483), Expect = 9e-50
Identities = 92/222 (41%), Positives = 142/222 (63%), Gaps = 5/222 (2%)
Query: 786 DYIYE-CHQPRP-LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y H P L+S L+ A+Q+ARGMEYLA++K +H DLAARNVL+ +DNV+KI D
Sbjct: 582 EYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIAD 641
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR +++ + Y+K N LPVKW+A E + DRI++ QSDVWS+G++LWE+F+L +PY
Sbjct: 642 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 701
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P + +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L +
Sbjct: 702 PGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALT 761
Query: 964 ERNRYVDLNAPYNEMNAELMTGEDYLAMVCAPDYNNIVTPSP 1005
Y+DL+ P ++ + D + C+ +++ + P
Sbjct: 762 SNQEYLDLSMPLDQYSPSF---PDTRSSTCSSGEDSVFSHEP 800
Score = 97.5 bits (232), Expect = 2e-19
Identities = 54/116 (46%), Positives = 70/116 (60%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVT--TPVAVKMVKRTADNMY 653
LP D ++E PR++L GK LG G FG V AEA G+ + T VAVKM+K A
Sbjct: 465 LPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD 524
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y+Q R
Sbjct: 525 LSDLISEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLQARR 577
Score = 36.3 bits (80), Expect = 0.64
Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 4/68 (5%)
Query: 260 TDIANYTLVAENKYLTKNYTVDLRVFTK-PEAKLLNNRIIKRLE---NSEMNFACKVTGY 315
+D NYT + EN+Y + N+T L V + P +L + S + F CKV
Sbjct: 223 SDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 282
Query: 316 PLPDVTWI 323
P P + W+
Sbjct: 283 PQPHIQWL 290
Score = 34.7 bits (76), Expect = 1.9
Identities = 20/90 (22%), Positives = 38/90 (42%), Gaps = 8/90 (8%)
Query: 450 RSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDN 507
++++ C + G P PT+ W K N +K I + + +T+ I +++ D
Sbjct: 172 KTVKFKCPSSGTPNPTLRWLK------NGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 225
Query: 508 GIYECVALNNASELRRAYTLVLKAEKSYTP 537
G Y C+ N + Y L + + P
Sbjct: 226 GNYTCIVENEYGSINHTYQLDVVERSPHRP 255
Score = 32.7 bits (71), Expect = 7.9
Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 9/99 (9%)
Query: 86 KKPPKPKVAGG---HKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVE------VS 136
+ P +P + G +K G C+V +D + +W EV + V
Sbjct: 250 RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQ 309
Query: 137 VVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCG 175
++KT T + + +RN + + G YTCL N+ G
Sbjct: 310 ILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG 348
>M63887-1|AAA35958.1| 822|Homo sapiens heparin-binding growth factor
receptor protein.
Length = 822
Score = 198 bits (483), Expect = 9e-50
Identities = 92/222 (41%), Positives = 142/222 (63%), Gaps = 5/222 (2%)
Query: 786 DYIYE-CHQPRP-LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y H P L+S L+ A+Q+ARGMEYLA++K +H DLAARNVL+ +DNV+KI D
Sbjct: 582 EYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIAD 641
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR +++ + Y+K N LPVKW+A E + DRI++ QSDVWS+G++LWE+F+L +PY
Sbjct: 642 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 701
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P + +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L +
Sbjct: 702 PGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALT 761
Query: 964 ERNRYVDLNAPYNEMNAELMTGEDYLAMVCAPDYNNIVTPSP 1005
Y+DL+ P ++ + D + C+ +++ + P
Sbjct: 762 SNQEYLDLSMPLDQYSPSF---PDTRSSTCSSGEDSVFSHEP 800
Score = 97.5 bits (232), Expect = 2e-19
Identities = 54/116 (46%), Positives = 70/116 (60%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVT--TPVAVKMVKRTADNMY 653
LP D ++E PR++L GK LG G FG V AEA G+ + T VAVKM+K A
Sbjct: 465 LPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD 524
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y+Q R
Sbjct: 525 LSDLISEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLQARR 577
Score = 36.3 bits (80), Expect = 0.64
Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 4/68 (5%)
Query: 260 TDIANYTLVAENKYLTKNYTVDLRVFTK-PEAKLLNNRIIKRLE---NSEMNFACKVTGY 315
+D NYT + EN+Y + N+T L V + P +L + S + F CKV
Sbjct: 223 SDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 282
Query: 316 PLPDVTWI 323
P P + W+
Sbjct: 283 PQPHIQWL 290
Score = 34.7 bits (76), Expect = 1.9
Identities = 20/90 (22%), Positives = 38/90 (42%), Gaps = 8/90 (8%)
Query: 450 RSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDN 507
++++ C + G P PT+ W K N +K I + + +T+ I +++ D
Sbjct: 172 KTVKFKCPSSGTPNPTLRWLK------NGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 225
Query: 508 GIYECVALNNASELRRAYTLVLKAEKSYTP 537
G Y C+ N + Y L + + P
Sbjct: 226 GNYTCIVENEYGSINHTYQLDVVERSPHRP 255
>M60485-1|AAA35840.1| 820|Homo sapiens fibroblast growth factor
receptor protein.
Length = 820
Score = 198 bits (483), Expect = 9e-50
Identities = 92/222 (41%), Positives = 142/222 (63%), Gaps = 5/222 (2%)
Query: 786 DYIYE-CHQPRP-LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y H P L+S L+ A+Q+ARGMEYLA++K +H DLAARNVL+ +DNV+KI D
Sbjct: 580 EYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIAD 639
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR +++ + Y+K N LPVKW+A E + DRI++ QSDVWS+G++LWE+F+L +PY
Sbjct: 640 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 699
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P + +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L +
Sbjct: 700 PGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALT 759
Query: 964 ERNRYVDLNAPYNEMNAELMTGEDYLAMVCAPDYNNIVTPSP 1005
Y+DL+ P ++ + D + C+ +++ + P
Sbjct: 760 SNQEYLDLSMPLDQYSPSF---PDTRSSTCSSGEDSVFSHEP 798
Score = 97.5 bits (232), Expect = 2e-19
Identities = 54/116 (46%), Positives = 70/116 (60%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVT--TPVAVKMVKRTADNMY 653
LP D ++E PR++L GK LG G FG V AEA G+ + T VAVKM+K A
Sbjct: 463 LPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD 522
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y+Q R
Sbjct: 523 LSDLISEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLQARR 575
Score = 36.3 bits (80), Expect = 0.64
Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 4/68 (5%)
Query: 260 TDIANYTLVAENKYLTKNYTVDLRVFTK-PEAKLLNNRIIKRLE---NSEMNFACKVTGY 315
+D NYT + EN+Y + N+T L V + P +L + S + F CKV
Sbjct: 221 SDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 280
Query: 316 PLPDVTWI 323
P P + W+
Sbjct: 281 PQPHIQWL 288
Score = 34.7 bits (76), Expect = 1.9
Identities = 20/90 (22%), Positives = 38/90 (42%), Gaps = 8/90 (8%)
Query: 450 RSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDN 507
++++ C + G P PT+ W K N +K I + + +T+ I +++ D
Sbjct: 170 KTVKFKCPSSGTPNPTLRWLK------NGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 223
Query: 508 GIYECVALNNASELRRAYTLVLKAEKSYTP 537
G Y C+ N + Y L + + P
Sbjct: 224 GNYTCIVENEYGSINHTYQLDVVERSPHRP 253
Score = 32.7 bits (71), Expect = 7.9
Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 9/99 (9%)
Query: 86 KKPPKPKVAGG---HKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVE------VS 136
+ P +P + G +K G C+V +D + +W EV + V
Sbjct: 248 RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQ 307
Query: 137 VVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCG 175
++KT T + + +RN + + G YTCL N+ G
Sbjct: 308 ILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG 346
>M37722-1|AAA75007.1| 731|Homo sapiens basic fibroblast growth factor
receptor protein protein.
Length = 731
Score = 198 bits (483), Expect = 9e-50
Identities = 92/222 (41%), Positives = 142/222 (63%), Gaps = 5/222 (2%)
Query: 786 DYIYE-CHQPRP-LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y H P L+S L+ A+Q+ARGMEYLA++K +H DLAARNVL+ +DNV+KI D
Sbjct: 491 EYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIAD 550
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR +++ + Y+K N LPVKW+A E + DRI++ QSDVWS+G++LWE+F+L +PY
Sbjct: 551 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 610
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P + +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L +
Sbjct: 611 PGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALT 670
Query: 964 ERNRYVDLNAPYNEMNAELMTGEDYLAMVCAPDYNNIVTPSP 1005
Y+DL+ P ++ + D + C+ +++ + P
Sbjct: 671 SNQEYLDLSMPLDQYSPSF---PDTRSSTCSSGEDSVFSHEP 709
Score = 96.7 bits (230), Expect = 4e-19
Identities = 54/116 (46%), Positives = 70/116 (60%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVT--TPVAVKMVKRTADNMY 653
LP D ++E PR++L GK LG G FG V AEA G+ + T VAVKM+K A
Sbjct: 374 LPEDLRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD 433
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y+Q R
Sbjct: 434 LSDLISEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLQARR 486
Score = 36.3 bits (80), Expect = 0.64
Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 4/68 (5%)
Query: 260 TDIANYTLVAENKYLTKNYTVDLRVFTK-PEAKLLNNRIIKRLE---NSEMNFACKVTGY 315
+D NYT + EN+Y + N+T L V + P +L + S + F CKV
Sbjct: 132 SDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 191
Query: 316 PLPDVTWI 323
P P + W+
Sbjct: 192 PQPHIQWL 199
Score = 34.7 bits (76), Expect = 1.9
Identities = 20/90 (22%), Positives = 38/90 (42%), Gaps = 8/90 (8%)
Query: 450 RSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDN 507
++++ C + G P PT+ W K N +K I + + +T+ I +++ D
Sbjct: 81 KTVKFKCPSSGTPNPTLRWLK------NGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 134
Query: 508 GIYECVALNNASELRRAYTLVLKAEKSYTP 537
G Y C+ N + Y L + + P
Sbjct: 135 GNYTCIVENEYGSINHTYQLDVVERSPHRP 164
Score = 32.7 bits (71), Expect = 7.9
Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 9/99 (9%)
Query: 86 KKPPKPKVAGG---HKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVE------VS 136
+ P +P + G +K G C+V +D + +W EV + V
Sbjct: 159 RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQ 218
Query: 137 VVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCG 175
++KT T + + +RN + + G YTCL N+ G
Sbjct: 219 ILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG 257
>M34641-1|AAA35835.1| 820|Homo sapiens protein ( Human fibroblast
growth factor (FGF) receptor-1 mRNA, complete cds. ).
Length = 820
Score = 198 bits (483), Expect = 9e-50
Identities = 92/222 (41%), Positives = 142/222 (63%), Gaps = 5/222 (2%)
Query: 786 DYIYE-CHQPRP-LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y H P L+S L+ A+Q+ARGMEYLA++K +H DLAARNVL+ +DNV+KI D
Sbjct: 580 EYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIAD 639
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR +++ + Y+K N LPVKW+A E + DRI++ QSDVWS+G++LWE+F+L +PY
Sbjct: 640 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 699
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P + +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L +
Sbjct: 700 PGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALT 759
Query: 964 ERNRYVDLNAPYNEMNAELMTGEDYLAMVCAPDYNNIVTPSP 1005
Y+DL+ P ++ + D + C+ +++ + P
Sbjct: 760 SNQEYLDLSMPLDQYSPSF---PDTRSSTCSSGEDSVFSHEP 798
Score = 97.5 bits (232), Expect = 2e-19
Identities = 54/116 (46%), Positives = 70/116 (60%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVT--TPVAVKMVKRTADNMY 653
LP D ++E PR++L GK LG G FG V AEA G+ + T VAVKM+K A
Sbjct: 463 LPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD 522
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y+Q R
Sbjct: 523 LSDLISEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLQARR 575
Score = 36.3 bits (80), Expect = 0.64
Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 4/68 (5%)
Query: 260 TDIANYTLVAENKYLTKNYTVDLRVFTK-PEAKLLNNRIIKRLE---NSEMNFACKVTGY 315
+D NYT + EN+Y + N+T L V + P +L + S + F CKV
Sbjct: 221 SDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 280
Query: 316 PLPDVTWI 323
P P + W+
Sbjct: 281 PQPHIQWL 288
Score = 35.1 bits (77), Expect = 1.5
Identities = 20/90 (22%), Positives = 39/90 (43%), Gaps = 8/90 (8%)
Query: 450 RSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDN 507
++++ C + G P PT+ W K N+ +K I + + +T+ I +++ D
Sbjct: 170 KTVKFKCPSSGTPNPTLRWLK------NSKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 223
Query: 508 GIYECVALNNASELRRAYTLVLKAEKSYTP 537
G Y C+ N + Y L + + P
Sbjct: 224 GNYTCIVENEYGSINHTYQLDVVERSPHRP 253
Score = 32.7 bits (71), Expect = 7.9
Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 9/99 (9%)
Query: 86 KKPPKPKVAGG---HKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVE------VS 136
+ P +P + G +K G C+V +D + +W EV + V
Sbjct: 248 RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQ 307
Query: 137 VVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCG 175
++KT T + + +RN + + G YTCL N+ G
Sbjct: 308 ILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG 346
>M34186-1|AAA35837.1| 731|Homo sapiens protein ( Human fibroblast
growth factor receptor (FGFr) transmembrane form mRNA,
complete cds. ).
Length = 731
Score = 198 bits (483), Expect = 9e-50
Identities = 92/222 (41%), Positives = 142/222 (63%), Gaps = 5/222 (2%)
Query: 786 DYIYE-CHQPRP-LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y H P L+S L+ A+Q+ARGMEYLA++K +H DLAARNVL+ +DNV+KI D
Sbjct: 491 EYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIAD 550
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR +++ + Y+K N LPVKW+A E + DRI++ QSDVWS+G++LWE+F+L +PY
Sbjct: 551 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 610
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P + +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L +
Sbjct: 611 PGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALT 670
Query: 964 ERNRYVDLNAPYNEMNAELMTGEDYLAMVCAPDYNNIVTPSP 1005
Y+DL+ P ++ + D + C+ +++ + P
Sbjct: 671 SNQEYLDLSMPLDQYSPSF---PDTRSSTCSSGEDSVFSHEP 709
Score = 97.5 bits (232), Expect = 2e-19
Identities = 54/116 (46%), Positives = 70/116 (60%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVT--TPVAVKMVKRTADNMY 653
LP D ++E PR++L GK LG G FG V AEA G+ + T VAVKM+K A
Sbjct: 374 LPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD 433
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y+Q R
Sbjct: 434 LSDLISEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLQARR 486
Score = 36.3 bits (80), Expect = 0.64
Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 4/68 (5%)
Query: 260 TDIANYTLVAENKYLTKNYTVDLRVFTK-PEAKLLNNRIIKRLE---NSEMNFACKVTGY 315
+D NYT + EN+Y + N+T L V + P +L + S + F CKV
Sbjct: 132 SDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 191
Query: 316 PLPDVTWI 323
P P + W+
Sbjct: 192 PQPHIQWL 199
Score = 33.9 bits (74), Expect = 3.4
Identities = 19/90 (21%), Positives = 38/90 (42%), Gaps = 8/90 (8%)
Query: 450 RSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDN 507
++++ C + G P PT+ W + N +K I + + +T+ I +++ D
Sbjct: 81 KTVKFKCPSSGTPNPTLRW------LENGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 134
Query: 508 GIYECVALNNASELRRAYTLVLKAEKSYTP 537
G Y C+ N + Y L + + P
Sbjct: 135 GNYTCIVENEYGSINHTYQLDVVERSPHRP 164
Score = 32.7 bits (71), Expect = 7.9
Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 9/99 (9%)
Query: 86 KKPPKPKVAGG---HKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVE------VS 136
+ P +P + G +K G C+V +D + +W EV + V
Sbjct: 159 RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQ 218
Query: 137 VVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCG 175
++KT T + + +RN + + G YTCL N+ G
Sbjct: 219 ILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG 257
>M34185-1|AAA35836.1| 733|Homo sapiens protein ( Human fibroblast
growth factor receptor (FGFr) transmembrane form mRNA,
complete cds. ).
Length = 733
Score = 198 bits (483), Expect = 9e-50
Identities = 92/222 (41%), Positives = 142/222 (63%), Gaps = 5/222 (2%)
Query: 786 DYIYE-CHQPRP-LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y H P L+S L+ A+Q+ARGMEYLA++K +H DLAARNVL+ +DNV+KI D
Sbjct: 493 EYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIAD 552
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR +++ + Y+K N LPVKW+A E + DRI++ QSDVWS+G++LWE+F+L +PY
Sbjct: 553 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 612
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P + +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L +
Sbjct: 613 PGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALT 672
Query: 964 ERNRYVDLNAPYNEMNAELMTGEDYLAMVCAPDYNNIVTPSP 1005
Y+DL+ P ++ + D + C+ +++ + P
Sbjct: 673 SNQEYLDLSMPLDQYSPSF---PDTRSSTCSSGEDSVFSHEP 711
Score = 97.5 bits (232), Expect = 2e-19
Identities = 54/116 (46%), Positives = 70/116 (60%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVT--TPVAVKMVKRTADNMY 653
LP D ++E PR++L GK LG G FG V AEA G+ + T VAVKM+K A
Sbjct: 376 LPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD 435
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y+Q R
Sbjct: 436 LSDLISEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLQARR 488
Score = 36.3 bits (80), Expect = 0.64
Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 4/68 (5%)
Query: 260 TDIANYTLVAENKYLTKNYTVDLRVFTK-PEAKLLNNRIIKRLE---NSEMNFACKVTGY 315
+D NYT + EN+Y + N+T L V + P +L + S + F CKV
Sbjct: 134 SDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 193
Query: 316 PLPDVTWI 323
P P + W+
Sbjct: 194 PQPHIQWL 201
Score = 34.7 bits (76), Expect = 1.9
Identities = 20/90 (22%), Positives = 38/90 (42%), Gaps = 8/90 (8%)
Query: 450 RSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDN 507
++++ C + G P PT+ W K N +K I + + +T+ I +++ D
Sbjct: 83 KTVKFKCPSSGTPNPTLRWLK------NGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 136
Query: 508 GIYECVALNNASELRRAYTLVLKAEKSYTP 537
G Y C+ N + Y L + + P
Sbjct: 137 GNYTCIVENEYGSINHTYQLDVVERSPHRP 166
Score = 32.7 bits (71), Expect = 7.9
Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 9/99 (9%)
Query: 86 KKPPKPKVAGG---HKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVE------VS 136
+ P +P + G +K G C+V +D + +W EV + V
Sbjct: 161 RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQ 220
Query: 137 VVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCG 175
++KT T + + +RN + + G YTCL N+ G
Sbjct: 221 ILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG 259
>BC091494-1|AAH91494.1| 731|Homo sapiens fibroblast growth factor
receptor 1 (fms-related tyrosine kinase 2, Pfeiffer sy
protein.
Length = 731
Score = 198 bits (483), Expect = 9e-50
Identities = 92/222 (41%), Positives = 142/222 (63%), Gaps = 5/222 (2%)
Query: 786 DYIYE-CHQPRP-LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y H P L+S L+ A+Q+ARGMEYLA++K +H DLAARNVL+ +DNV+KI D
Sbjct: 491 EYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIAD 550
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR +++ + Y+K N LPVKW+A E + DRI++ QSDVWS+G++LWE+F+L +PY
Sbjct: 551 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 610
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P + +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L +
Sbjct: 611 PGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALT 670
Query: 964 ERNRYVDLNAPYNEMNAELMTGEDYLAMVCAPDYNNIVTPSP 1005
Y+DL+ P ++ + D + C+ +++ + P
Sbjct: 671 SNQEYLDLSMPLDQYSPSF---PDTRSSTCSSGEDSVFSHEP 709
Score = 97.5 bits (232), Expect = 2e-19
Identities = 54/116 (46%), Positives = 70/116 (60%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVT--TPVAVKMVKRTADNMY 653
LP D ++E PR++L GK LG G FG V AEA G+ + T VAVKM+K A
Sbjct: 374 LPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD 433
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y+Q R
Sbjct: 434 LSDLISEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLQARR 486
Score = 36.3 bits (80), Expect = 0.64
Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 4/68 (5%)
Query: 260 TDIANYTLVAENKYLTKNYTVDLRVFTK-PEAKLLNNRIIKRLE---NSEMNFACKVTGY 315
+D NYT + EN+Y + N+T L V + P +L + S + F CKV
Sbjct: 132 SDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 191
Query: 316 PLPDVTWI 323
P P + W+
Sbjct: 192 PQPHIQWL 199
Score = 34.7 bits (76), Expect = 1.9
Identities = 20/90 (22%), Positives = 38/90 (42%), Gaps = 8/90 (8%)
Query: 450 RSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDN 507
++++ C + G P PT+ W K N +K I + + +T+ I +++ D
Sbjct: 81 KTVKFKCPSSGTPNPTLRWLK------NGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 134
Query: 508 GIYECVALNNASELRRAYTLVLKAEKSYTP 537
G Y C+ N + Y L + + P
Sbjct: 135 GNYTCIVENEYGSINHTYQLDVVERSPHRP 164
Score = 32.7 bits (71), Expect = 7.9
Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 9/99 (9%)
Query: 86 KKPPKPKVAGG---HKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVE------VS 136
+ P +P + G +K G C+V +D + +W EV + V
Sbjct: 159 RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQ 218
Query: 137 VVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCG 175
++KT T + + +RN + + G YTCL N+ G
Sbjct: 219 ILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG 257
>BC018128-1|AAH18128.1| 820|Homo sapiens fibroblast growth factor
receptor 1 (fms-related tyrosine kinase 2, Pfeiffer sy
protein.
Length = 820
Score = 198 bits (483), Expect = 9e-50
Identities = 92/222 (41%), Positives = 142/222 (63%), Gaps = 5/222 (2%)
Query: 786 DYIYE-CHQPRP-LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y H P L+S L+ A+Q+ARGMEYLA++K +H DLAARNVL+ +DNV+KI D
Sbjct: 580 EYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIAD 639
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR +++ + Y+K N LPVKW+A E + DRI++ QSDVWS+G++LWE+F+L +PY
Sbjct: 640 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 699
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P + +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L +
Sbjct: 700 PGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALT 759
Query: 964 ERNRYVDLNAPYNEMNAELMTGEDYLAMVCAPDYNNIVTPSP 1005
Y+DL+ P ++ + D + C+ +++ + P
Sbjct: 760 SNQEYLDLSMPLDQYSPSF---PDTRSSTCSSGEDSVFSHEP 798
Score = 97.5 bits (232), Expect = 2e-19
Identities = 54/116 (46%), Positives = 70/116 (60%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVT--TPVAVKMVKRTADNMY 653
LP D ++E PR++L GK LG G FG V AEA G+ + T VAVKM+K A
Sbjct: 463 LPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD 522
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y+Q R
Sbjct: 523 LSDLISEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLQARR 575
Score = 37.1 bits (82), Expect = 0.37
Identities = 29/109 (26%), Positives = 48/109 (44%), Gaps = 7/109 (6%)
Query: 220 PVERTHFLKNDK-YLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLTKNY 278
P +LKN K + P + + A G + ++ + +D NYT + EN+Y + N+
Sbjct: 182 PNPTLRWLKNGKEFKPDHRIGGYKVRYATGS--IIMDSVVPSDKGNYTCIVENEYGSINH 239
Query: 279 TVDLRVFTK-PEAKLLNNRIIKRLE---NSEMNFACKVTGYPLPDVTWI 323
T L V + P +L + S + F CKV P P + W+
Sbjct: 240 TYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWL 288
Score = 33.9 bits (74), Expect = 3.4
Identities = 20/91 (21%), Positives = 39/91 (42%), Gaps = 10/91 (10%)
Query: 450 RSIQLHCEAEGVPRPTIYWYKDDELISNN---SGYKLFVDIVNHTIVNSTFEIENMQEKD 506
++++ C + G P PT+ W K+ + + GYK V +I+ ++++ D
Sbjct: 170 KTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYK--VRYATGSII-----MDSVVPSD 222
Query: 507 NGIYECVALNNASELRRAYTLVLKAEKSYTP 537
G Y C+ N + Y L + + P
Sbjct: 223 KGNYTCIVENEYGSINHTYQLDVVERSPHRP 253
Score = 32.7 bits (71), Expect = 7.9
Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 9/99 (9%)
Query: 86 KKPPKPKVAGG---HKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVE------VS 136
+ P +P + G +K G C+V +D + +W EV + V
Sbjct: 248 RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQ 307
Query: 137 VVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCG 175
++KT T + + +RN + + G YTCL N+ G
Sbjct: 308 ILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG 346
>BC015035-1|AAH15035.1| 820|Homo sapiens FGFR1 protein protein.
Length = 820
Score = 198 bits (483), Expect = 9e-50
Identities = 92/222 (41%), Positives = 142/222 (63%), Gaps = 5/222 (2%)
Query: 786 DYIYE-CHQPRP-LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y H P L+S L+ A+Q+ARGMEYLA++K +H DLAARNVL+ +DNV+KI D
Sbjct: 580 EYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIAD 639
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR +++ + Y+K N LPVKW+A E + DRI++ QSDVWS+G++LWE+F+L +PY
Sbjct: 640 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 699
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P + +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L +
Sbjct: 700 PGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALT 759
Query: 964 ERNRYVDLNAPYNEMNAELMTGEDYLAMVCAPDYNNIVTPSP 1005
Y+DL+ P ++ + D + C+ +++ + P
Sbjct: 760 SNQEYLDLSMPLDQYSPSF---PDTRSSTCSSGEDSVFSHEP 798
Score = 97.5 bits (232), Expect = 2e-19
Identities = 54/116 (46%), Positives = 70/116 (60%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVT--TPVAVKMVKRTADNMY 653
LP D ++E PR++L GK LG G FG V AEA G+ + T VAVKM+K A
Sbjct: 463 LPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD 522
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y+Q R
Sbjct: 523 LSDLISEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLQARR 575
Score = 36.3 bits (80), Expect = 0.64
Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 4/68 (5%)
Query: 260 TDIANYTLVAENKYLTKNYTVDLRVFTK-PEAKLLNNRIIKRLE---NSEMNFACKVTGY 315
+D NYT + EN+Y + N+T L V + P +L + S + F CKV
Sbjct: 223 SDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 282
Query: 316 PLPDVTWI 323
P P + W+
Sbjct: 283 PQPHIQWL 290
Score = 34.7 bits (76), Expect = 1.9
Identities = 20/90 (22%), Positives = 38/90 (42%), Gaps = 8/90 (8%)
Query: 450 RSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDN 507
++++ C + G P PT+ W K N +K I + + +T+ I +++ D
Sbjct: 172 KTVKFKCPSSGTPNPTLRWLK------NGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 225
Query: 508 GIYECVALNNASELRRAYTLVLKAEKSYTP 537
G Y C+ N + Y L + + P
Sbjct: 226 GNYTCIVENEYGSINHTYQLDVVERSPHRP 255
Score = 32.7 bits (71), Expect = 7.9
Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 9/99 (9%)
Query: 86 KKPPKPKVAGG---HKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVE------VS 136
+ P +P + G +K G C+V +D + +W EV + V
Sbjct: 250 RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQ 309
Query: 137 VVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCG 175
++KT T + + +RN + + G YTCL N+ G
Sbjct: 310 ILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG 348
>AY585209-1|AAS79322.1| 822|Homo sapiens fibroblast growth factor
receptor 1 (fms-related tyrosine kinase 2, Pfeiffer sy
protein.
Length = 822
Score = 198 bits (483), Expect = 9e-50
Identities = 92/222 (41%), Positives = 142/222 (63%), Gaps = 5/222 (2%)
Query: 786 DYIYE-CHQPRP-LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y H P L+S L+ A+Q+ARGMEYLA++K +H DLAARNVL+ +DNV+KI D
Sbjct: 582 EYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIAD 641
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR +++ + Y+K N LPVKW+A E + DRI++ QSDVWS+G++LWE+F+L +PY
Sbjct: 642 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 701
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P + +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L +
Sbjct: 702 PGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALT 761
Query: 964 ERNRYVDLNAPYNEMNAELMTGEDYLAMVCAPDYNNIVTPSP 1005
Y+DL+ P ++ + D + C+ +++ + P
Sbjct: 762 SNQEYLDLSMPLDQYSPSF---PDTRSSTCSSGEDSVFSHEP 800
Score = 97.5 bits (232), Expect = 2e-19
Identities = 54/116 (46%), Positives = 70/116 (60%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVT--TPVAVKMVKRTADNMY 653
LP D ++E PR++L GK LG G FG V AEA G+ + T VAVKM+K A
Sbjct: 465 LPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD 524
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y+Q R
Sbjct: 525 LSDLISEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLQARR 577
Score = 36.3 bits (80), Expect = 0.64
Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 4/68 (5%)
Query: 260 TDIANYTLVAENKYLTKNYTVDLRVFTK-PEAKLLNNRIIKRLE---NSEMNFACKVTGY 315
+D NYT + EN+Y + N+T L V + P +L + S + F CKV
Sbjct: 223 SDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 282
Query: 316 PLPDVTWI 323
P P + W+
Sbjct: 283 PQPHIQWL 290
Score = 34.7 bits (76), Expect = 1.9
Identities = 20/90 (22%), Positives = 38/90 (42%), Gaps = 8/90 (8%)
Query: 450 RSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDN 507
++++ C + G P PT+ W K N +K I + + +T+ I +++ D
Sbjct: 172 KTVKFKCPSSGTPNPTLRWLK------NGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 225
Query: 508 GIYECVALNNASELRRAYTLVLKAEKSYTP 537
G Y C+ N + Y L + + P
Sbjct: 226 GNYTCIVENEYGSINHTYQLDVVERSPHRP 255
Score = 32.7 bits (71), Expect = 7.9
Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 9/99 (9%)
Query: 86 KKPPKPKVAGG---HKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVE------VS 136
+ P +P + G +K G C+V +D + +W EV + V
Sbjct: 250 RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQ 309
Query: 137 VVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCG 175
++KT T + + +RN + + G YTCL N+ G
Sbjct: 310 ILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG 348
>AK222718-1|BAD96438.1| 820|Homo sapiens fibroblast growth factor
receptor 1 isoform 2 precursor variant protein.
Length = 820
Score = 198 bits (483), Expect = 9e-50
Identities = 92/222 (41%), Positives = 142/222 (63%), Gaps = 5/222 (2%)
Query: 786 DYIYE-CHQPRP-LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y H P L+S L+ A+Q+ARGMEYLA++K +H DLAARNVL+ +DNV+KI D
Sbjct: 580 EYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIAD 639
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR +++ + Y+K N LPVKW+A E + DRI++ QSDVWS+G++LWE+F+L +PY
Sbjct: 640 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 699
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P + +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L +
Sbjct: 700 PGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALT 759
Query: 964 ERNRYVDLNAPYNEMNAELMTGEDYLAMVCAPDYNNIVTPSP 1005
Y+DL+ P ++ + D + C+ +++ + P
Sbjct: 760 SNQEYLDLSMPLDQYSPSF---PDTRSSTCSSGEDSVFSHEP 798
Score = 95.5 bits (227), Expect = 1e-18
Identities = 53/116 (45%), Positives = 70/116 (60%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVT--TPVAVKMVKRTADNMY 653
LP D ++E PR++L G+ LG G FG V AEA G+ + T VAVKM+K A
Sbjct: 463 LPEDPRWELPRDRLVLGRPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD 522
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y+Q R
Sbjct: 523 LSDLISEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLQAWR 575
Score = 35.9 bits (79), Expect = 0.84
Identities = 21/67 (31%), Positives = 31/67 (46%), Gaps = 4/67 (5%)
Query: 261 DIANYTLVAENKYLTKNYTVDLRVFTK-PEAKLLNNRIIKRLE---NSEMNFACKVTGYP 316
D NYT + EN+Y + N+T L V + P +L + S + F CKV P
Sbjct: 222 DKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDP 281
Query: 317 LPDVTWI 323
P + W+
Sbjct: 282 QPHIQWL 288
Score = 33.5 bits (73), Expect = 4.5
Identities = 20/90 (22%), Positives = 38/90 (42%), Gaps = 8/90 (8%)
Query: 450 RSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDN 507
++++ C + G P PT+ W K N +K I + + +T+ I +++ D
Sbjct: 170 KTVKFKCPSSGTPNPTLRWLK------NGKEFKPDHRIGGYKVRYATWSIIMDSVVPFDK 223
Query: 508 GIYECVALNNASELRRAYTLVLKAEKSYTP 537
G Y C+ N + Y L + + P
Sbjct: 224 GNYTCIVENEYGSINHTYQLDVVERSPHRP 253
Score = 32.7 bits (71), Expect = 7.9
Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 9/99 (9%)
Query: 86 KKPPKPKVAGG---HKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVE------VS 136
+ P +P + G +K G C+V +D + +W EV + V
Sbjct: 248 RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQ 307
Query: 137 VVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCG 175
++KT T + + +RN + + G YTCL N+ G
Sbjct: 308 ILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG 346
>AB208919-1|BAD92156.1| 814|Homo sapiens fibroblast growth factor
receptor 1 isoform 1 precursor variant protein.
Length = 814
Score = 198 bits (483), Expect = 9e-50
Identities = 92/222 (41%), Positives = 142/222 (63%), Gaps = 5/222 (2%)
Query: 786 DYIYE-CHQPRP-LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y H P L+S L+ A+Q+ARGMEYLA++K +H DLAARNVL+ +DNV+KI D
Sbjct: 574 EYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIAD 633
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR +++ + Y+K N LPVKW+A E + DRI++ QSDVWS+G++LWE+F+L +PY
Sbjct: 634 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 693
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P + +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L +
Sbjct: 694 PGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALT 753
Query: 964 ERNRYVDLNAPYNEMNAELMTGEDYLAMVCAPDYNNIVTPSP 1005
Y+DL+ P ++ + D + C+ +++ + P
Sbjct: 754 SNQEYLDLSMPLDQYSPSF---PDTRSSTCSSGEDSVFSHEP 792
Score = 97.5 bits (232), Expect = 2e-19
Identities = 54/116 (46%), Positives = 70/116 (60%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVT--TPVAVKMVKRTADNMY 653
LP D ++E PR++L GK LG G FG V AEA G+ + T VAVKM+K A
Sbjct: 457 LPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD 516
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y+Q R
Sbjct: 517 LSDLISEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLQARR 569
Score = 36.3 bits (80), Expect = 0.64
Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 4/68 (5%)
Query: 260 TDIANYTLVAENKYLTKNYTVDLRVFTK-PEAKLLNNRIIKRLE---NSEMNFACKVTGY 315
+D NYT + EN+Y + N+T L V + P +L + S + F CKV
Sbjct: 217 SDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 276
Query: 316 PLPDVTWI 323
P P + W+
Sbjct: 277 PQPHIQWL 284
Score = 34.7 bits (76), Expect = 1.9
Identities = 20/90 (22%), Positives = 38/90 (42%), Gaps = 8/90 (8%)
Query: 450 RSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDN 507
++++ C + G P PT+ W K N +K I + + +T+ I +++ D
Sbjct: 166 KTVKFKCPSSGTPNPTLRWLK------NGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 219
Query: 508 GIYECVALNNASELRRAYTLVLKAEKSYTP 537
G Y C+ N + Y L + + P
Sbjct: 220 GNYTCIVENEYGSINHTYQLDVVERSPHRP 249
Score = 32.7 bits (71), Expect = 7.9
Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 9/99 (9%)
Query: 86 KKPPKPKVAGG---HKQFLEGETFTIHCRVPNDGLINFKWKYPPEVTNDSVE------VS 136
+ P +P + G +K G C+V +D + +W EV + V
Sbjct: 244 RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQ 303
Query: 137 VVKTEATTTGSIVYQNITIRNATKKHNGVYTCLLTNTCG 175
++KT T + + +RN + + G YTCL N+ G
Sbjct: 304 ILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG 342
>X68203-1|CAA48290.1| 1304|Homo sapiens FTL4 protein.
Length = 1304
Score = 193 bits (471), Expect = 3e-48
Identities = 84/167 (50%), Positives = 123/167 (73%), Gaps = 1/167 (0%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
PLT L+ ++FQ+ARGME+LA+RK +H DLAARN+LL++ +VVKICDFGLAR +Y + +
Sbjct: 1014 PLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPD 1073
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS-PTDLLRW 914
Y +K ++ LP+KW+A E + D++++TQSDVWS+G++LWE+FSL +PYP + + +
Sbjct: 1074 YVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQR 1133
Query: 915 LSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
L DG R+ P A + +ML CW P ARP+F+EL EILG+ L+
Sbjct: 1134 LRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQ 1180
Score = 149 bits (360), Expect = 8e-35
Identities = 93/267 (34%), Positives = 143/267 (53%), Gaps = 19/267 (7%)
Query: 451 SIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIY 510
S+++ C G P+I WYKD+ L+ SG VD+ + N I+ ++E+D G Y
Sbjct: 700 SLEMQCLVAGAHAPSIVWYKDERLLEEKSG----VDLADS---NQKLSIQRVREEDAGRY 752
Query: 511 ECVALNNASELRRAYTLVLKAEKSYTPYXXXXXXXXXXXXGMVAYLFTWKLKKQR--ELT 568
C N + + ++ ++ + G++A F W L +
Sbjct: 753 LCSVCNAKGCVNSSASVAVEGSED----KGSMEIVILVGTGVIAVFF-WVLLLLIFCNMR 807
Query: 569 KAGLLNFKSGNKKSF-NPN-LGIDEQADLLPYD-EKFEFPREKLTFGKQLGAGAFGVVYK 625
+ + K+G +P + ++EQ + L YD ++EFPRE+L G+ LG GAFG V +
Sbjct: 808 RPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVE 867
Query: 626 AEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIA 685
A A GI VAVKM+K A +AL SELKI++H+G H+N+VNLLGACTK
Sbjct: 868 ASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTK--P 925
Query: 686 KRELIVIVEYCKYGNIHNYMQKHREVF 712
+ L+VIVE+CKYGN+ N+++ R+ F
Sbjct: 926 QGPLMVIVEFCKYGNLSNFLRAKRDAF 952
Score = 52.8 bits (121), Expect = 7e-06
Identities = 92/402 (22%), Positives = 158/402 (39%), Gaps = 41/402 (10%)
Query: 99 QFLEGETFTIHCRVP---NDGLINFKWKYPPEVTNDSVEVSVVKTEATTTGSIVYQNITI 155
+ L GE ++C V N G + F W YP + V +++ T T + +TI
Sbjct: 247 ELLVGEKLVLNCTVWAEFNSG-VTFDWDYPGKQAERGKWVPERRSQQTHTE--LSSILTI 303
Query: 156 RNATKKHNGVYTCLLTNTCGEEKDEFRKIFLEKPFLSLRDLAKGKLMGNA-NKSINIVIE 214
N ++ G Y C N ++ I E PF+S+ L L A ++ + + ++
Sbjct: 304 HNVSQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLPVK 363
Query: 215 IEAYPPVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKY- 273
+ AYPP E + K+ K L + L + ++ YTL N
Sbjct: 364 LAAYPPPE-FQWYKDGKALSGR----------HSPHALVLKEVTEASTGTYTLALWNSAA 412
Query: 274 -LTKNYTVDLRVFTKP---EAKLLNNRIIKRLENSEMNFACKVTGYPLP-DVTWIFSNDE 328
L +N +++L V P E + + I R +S C G PLP + W +
Sbjct: 413 GLRRNISLELVVNVPPQIHEKEASSPSIYSR--HSRQALTCTAYGVPLPLSIQWHWRPWT 470
Query: 329 EHELSSTKSEQESLYAKTDYLKISVQASGVITCNAHNSKGEYFDSSTLLVYEINNGFGIL 388
++ + +S + + D + V T +A N E D+ T V N L
Sbjct: 471 PCKMFAQRSLRRR--QQQDLMPQCRDWRAVTTQDAVNPI-ESLDTWTEFVEGKNKTVSKL 527
Query: 389 QPLENWYSEKDSARKKCLASVYDYDNVSWLGSDGNILDDIELLAPIIREPDSNKDEEAME 448
++N SA KC+ S + +G D ++ P +S EE +E
Sbjct: 528 -VIQN---ANVSAMYKCVVS-------NKVGQDERLIYFYVTTIPDGFTIESKPSEELLE 576
Query: 449 GRSIQLHCEAEGVPRPTIYWYK-DDELISNNSGYKLFVDIVN 489
G+ + L C+A+ + WY+ + + + G L +D N
Sbjct: 577 GQPVLLSCQADSYKYEHLRWYRLNLSTLHDAHGNPLLLDCKN 618
>U43143-1|AAA85215.1| 1298|Homo sapiens Flt4 protein.
Length = 1298
Score = 193 bits (471), Expect = 3e-48
Identities = 84/167 (50%), Positives = 123/167 (73%), Gaps = 1/167 (0%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
PLT L+ ++FQ+ARGME+LA+RK +H DLAARN+LL++ +VVKICDFGLAR +Y + +
Sbjct: 1008 PLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPD 1067
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS-PTDLLRW 914
Y +K ++ LP+KW+A E + D++++TQSDVWS+G++LWE+FSL +PYP + + +
Sbjct: 1068 YVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQR 1127
Query: 915 LSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
L DG R+ P A + +ML CW P ARP+F+EL EILG+ L+
Sbjct: 1128 LRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQ 1174
Score = 149 bits (360), Expect = 8e-35
Identities = 93/267 (34%), Positives = 143/267 (53%), Gaps = 19/267 (7%)
Query: 451 SIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIY 510
S+++ C G P+I WYKD+ L+ SG VD+ + N I+ ++E+D G Y
Sbjct: 694 SLEMQCLVAGAHAPSIVWYKDERLLEEKSG----VDLADS---NQKLSIQRVREEDAGRY 746
Query: 511 ECVALNNASELRRAYTLVLKAEKSYTPYXXXXXXXXXXXXGMVAYLFTWKLKKQR--ELT 568
C N + + ++ ++ + G++A F W L +
Sbjct: 747 LCSVCNAKGCVNSSASVAVEGSED----KGSMEIVILVGTGVIAVFF-WVLLLLIFCNMR 801
Query: 569 KAGLLNFKSGNKKSF-NPN-LGIDEQADLLPYD-EKFEFPREKLTFGKQLGAGAFGVVYK 625
+ + K+G +P + ++EQ + L YD ++EFPRE+L G+ LG GAFG V +
Sbjct: 802 RPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVE 861
Query: 626 AEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIA 685
A A GI VAVKM+K A +AL SELKI++H+G H+N+VNLLGACTK
Sbjct: 862 ASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTK--P 919
Query: 686 KRELIVIVEYCKYGNIHNYMQKHREVF 712
+ L+VIVE+CKYGN+ N+++ R+ F
Sbjct: 920 QGPLMVIVEFCKYGNLSNFLRAKRDAF 946
Score = 52.8 bits (121), Expect = 7e-06
Identities = 92/402 (22%), Positives = 158/402 (39%), Gaps = 41/402 (10%)
Query: 99 QFLEGETFTIHCRVP---NDGLINFKWKYPPEVTNDSVEVSVVKTEATTTGSIVYQNITI 155
+ L GE ++C V N G + F W YP + V +++ T T + +TI
Sbjct: 241 ELLVGEKLVLNCTVWAEFNSG-VTFDWDYPGKQAERGKWVPERRSQQTHTE--LSSILTI 297
Query: 156 RNATKKHNGVYTCLLTNTCGEEKDEFRKIFLEKPFLSLRDLAKGKLMGNA-NKSINIVIE 214
N ++ G Y C N ++ I E PF+S+ L L A ++ + + ++
Sbjct: 298 HNVSQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLPVK 357
Query: 215 IEAYPPVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKY- 273
+ AYPP E + K+ K L + L + ++ YTL N
Sbjct: 358 LAAYPPPE-FQWYKDGKALSGR----------HSPHALVLKEVTEASTGTYTLALWNSAA 406
Query: 274 -LTKNYTVDLRVFTKP---EAKLLNNRIIKRLENSEMNFACKVTGYPLP-DVTWIFSNDE 328
L +N +++L V P E + + I R +S C G PLP + W +
Sbjct: 407 GLRRNISLELVVNVPPQIHEKEASSPSIYSR--HSRQALTCTAYGVPLPLSIQWHWRPWT 464
Query: 329 EHELSSTKSEQESLYAKTDYLKISVQASGVITCNAHNSKGEYFDSSTLLVYEINNGFGIL 388
++ + +S + + D + V T +A N E D+ T V N L
Sbjct: 465 PCKMFAQRSLRRR--QQQDLMPQCRDWRAVTTQDAVNPI-ESLDTWTEFVEGKNKTVSKL 521
Query: 389 QPLENWYSEKDSARKKCLASVYDYDNVSWLGSDGNILDDIELLAPIIREPDSNKDEEAME 448
++N SA KC+ S + +G D ++ P +S EE +E
Sbjct: 522 -VIQN---ANVSAMYKCVVS-------NKVGQDERLIYFYVTTIPDGFTIESKPSEELLE 570
Query: 449 GRSIQLHCEAEGVPRPTIYWYK-DDELISNNSGYKLFVDIVN 489
G+ + L C+A+ + WY+ + + + G L +D N
Sbjct: 571 GQPVLLSCQADSYKYEHLRWYRLNLSTLHDAHGNPLLLDCKN 612
>AY233383-1|AAO89505.1| 1363|Homo sapiens VEGFR3 long form protein.
Length = 1363
Score = 192 bits (469), Expect = 5e-48
Identities = 83/167 (49%), Positives = 124/167 (74%), Gaps = 1/167 (0%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
PLT L+ ++FQ+ARGME+LA+RK +H DLAARN+LL++ +VVKICDFGLAR +Y + +
Sbjct: 1008 PLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPD 1067
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS-PTDLLRW 914
Y +K ++ LP+KW+A E + D++++TQSDVWS+G++LWE+FSL +PYP + + +
Sbjct: 1068 YVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQR 1127
Query: 915 LSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
+ DG R+ P A + ++ML CW P ARP+F+EL EILG+ L+
Sbjct: 1128 VRDGTRMRAPELATPAIRHIMLNCWSGDPKARPAFSELVEILGDLLQ 1174
Score = 146 bits (354), Expect = 4e-34
Identities = 92/267 (34%), Positives = 142/267 (53%), Gaps = 19/267 (7%)
Query: 451 SIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIY 510
S+++ C G P+I WYKD+ L+ SG VD+ + N I+ ++E+D G Y
Sbjct: 694 SLEMQCLVAGAHAPSIVWYKDERLLEEKSG----VDLADS---NQKLSIQRVREEDAGPY 746
Query: 511 ECVALNNASELRRAYTLVLKAEKSYTPYXXXXXXXXXXXXGMVAYLFTWKLKKQR--ELT 568
C + + ++ ++ + G++A F W L +
Sbjct: 747 LCSVCRPKGCVNSSASVAVEGSED----KGSMEIVILVGTGVIAVFF-WVLLLLIFCNMR 801
Query: 569 KAGLLNFKSGNKKSF-NPN-LGIDEQADLLPYD-EKFEFPREKLTFGKQLGAGAFGVVYK 625
+ + K+G +P + ++EQ + L YD ++EFPRE+L G+ LG GAFG V +
Sbjct: 802 RPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVE 861
Query: 626 AEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIA 685
A A GI VAVKM+K A +AL SELKI++H+G H+N+VNLLGACTK
Sbjct: 862 ASAFGIHKGSSCDTVAVKMLKEGATASEQRALMSELKILIHIGNHLNVVNLLGACTK--P 919
Query: 686 KRELIVIVEYCKYGNIHNYMQKHREVF 712
+ L+VIVE+CKYGN+ N+++ R+ F
Sbjct: 920 QGPLMVIVEFCKYGNLSNFLRAKRDAF 946
Score = 52.8 bits (121), Expect = 7e-06
Identities = 92/402 (22%), Positives = 158/402 (39%), Gaps = 41/402 (10%)
Query: 99 QFLEGETFTIHCRVP---NDGLINFKWKYPPEVTNDSVEVSVVKTEATTTGSIVYQNITI 155
+ L GE ++C V N G + F W YP + V +++ T T + +TI
Sbjct: 241 ELLVGEKLVLNCTVWAEFNSG-VTFDWDYPGKQAERGKWVPERRSQQTHTE--LSSILTI 297
Query: 156 RNATKKHNGVYTCLLTNTCGEEKDEFRKIFLEKPFLSLRDLAKGKLMGNA-NKSINIVIE 214
N ++ G Y C N ++ I E PF+S+ L L A ++ + + ++
Sbjct: 298 HNVSQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLPVK 357
Query: 215 IEAYPPVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKY- 273
+ AYPP E + K+ K L + L + ++ YTL N
Sbjct: 358 LAAYPPPE-FQWYKDGKALSGR----------HSPHALVLKEVTEASTGTYTLALWNSAA 406
Query: 274 -LTKNYTVDLRVFTKP---EAKLLNNRIIKRLENSEMNFACKVTGYPLP-DVTWIFSNDE 328
L +N +++L V P E + + I R +S C G PLP + W +
Sbjct: 407 GLRRNISLELVVNVPPQIHEKEASSPSIYSR--HSRQALTCTAYGVPLPLSIQWHWRPWT 464
Query: 329 EHELSSTKSEQESLYAKTDYLKISVQASGVITCNAHNSKGEYFDSSTLLVYEINNGFGIL 388
++ + +S + + D + V T +A N E D+ T V N L
Sbjct: 465 PCKMFAQRSLRRR--QQQDLMPQCRDWRAVTTQDAVNPI-ESLDTWTEFVEGKNKTVSKL 521
Query: 389 QPLENWYSEKDSARKKCLASVYDYDNVSWLGSDGNILDDIELLAPIIREPDSNKDEEAME 448
++N SA KC+ S + +G D ++ P +S EE +E
Sbjct: 522 -VIQN---ANVSAMYKCVVS-------NKVGQDERLIYFYVTTIPDGFTIESKPSEELLE 570
Query: 449 GRSIQLHCEAEGVPRPTIYWYK-DDELISNNSGYKLFVDIVN 489
G+ + L C+A+ + WY+ + + + G L +D N
Sbjct: 571 GQPVLLSCQADSYKYEHLRWYRLNLSTLHDAHGNPLLLDCKN 612
>AY233382-1|AAO89504.1| 1298|Homo sapiens VEGFR3 short form protein.
Length = 1298
Score = 192 bits (469), Expect = 5e-48
Identities = 83/167 (49%), Positives = 124/167 (74%), Gaps = 1/167 (0%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
PLT L+ ++FQ+ARGME+LA+RK +H DLAARN+LL++ +VVKICDFGLAR +Y + +
Sbjct: 1008 PLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPD 1067
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS-PTDLLRW 914
Y +K ++ LP+KW+A E + D++++TQSDVWS+G++LWE+FSL +PYP + + +
Sbjct: 1068 YVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQR 1127
Query: 915 LSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
+ DG R+ P A + ++ML CW P ARP+F+EL EILG+ L+
Sbjct: 1128 VRDGTRMRAPELATPAIRHIMLNCWSGDPKARPAFSELVEILGDLLQ 1174
Score = 146 bits (354), Expect = 4e-34
Identities = 92/267 (34%), Positives = 142/267 (53%), Gaps = 19/267 (7%)
Query: 451 SIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIY 510
S+++ C G P+I WYKD+ L+ SG VD+ + N I+ ++E+D G Y
Sbjct: 694 SLEMQCLVAGAHAPSIVWYKDERLLEEKSG----VDLADS---NQKLSIQRVREEDAGPY 746
Query: 511 ECVALNNASELRRAYTLVLKAEKSYTPYXXXXXXXXXXXXGMVAYLFTWKLKKQR--ELT 568
C + + ++ ++ + G++A F W L +
Sbjct: 747 LCSVCRPKGCVNSSASVAVEGSED----KGSMEIVILVGTGVIAVFF-WVLLLLIFCNMR 801
Query: 569 KAGLLNFKSGNKKSF-NPN-LGIDEQADLLPYD-EKFEFPREKLTFGKQLGAGAFGVVYK 625
+ + K+G +P + ++EQ + L YD ++EFPRE+L G+ LG GAFG V +
Sbjct: 802 RPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVE 861
Query: 626 AEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIA 685
A A GI VAVKM+K A +AL SELKI++H+G H+N+VNLLGACTK
Sbjct: 862 ASAFGIHKGSSCDTVAVKMLKEGATASEQRALMSELKILIHIGNHLNVVNLLGACTK--P 919
Query: 686 KRELIVIVEYCKYGNIHNYMQKHREVF 712
+ L+VIVE+CKYGN+ N+++ R+ F
Sbjct: 920 QGPLMVIVEFCKYGNLSNFLRAKRDAF 946
Score = 52.8 bits (121), Expect = 7e-06
Identities = 92/402 (22%), Positives = 158/402 (39%), Gaps = 41/402 (10%)
Query: 99 QFLEGETFTIHCRVP---NDGLINFKWKYPPEVTNDSVEVSVVKTEATTTGSIVYQNITI 155
+ L GE ++C V N G + F W YP + V +++ T T + +TI
Sbjct: 241 ELLVGEKLVLNCTVWAEFNSG-VTFDWDYPGKQAERGKWVPERRSQQTHTE--LSSILTI 297
Query: 156 RNATKKHNGVYTCLLTNTCGEEKDEFRKIFLEKPFLSLRDLAKGKLMGNA-NKSINIVIE 214
N ++ G Y C N ++ I E PF+S+ L L A ++ + + ++
Sbjct: 298 HNVSQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLPVK 357
Query: 215 IEAYPPVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKY- 273
+ AYPP E + K+ K L + L + ++ YTL N
Sbjct: 358 LAAYPPPE-FQWYKDGKALSGR----------HSPHALVLKEVTEASTGTYTLALWNSAA 406
Query: 274 -LTKNYTVDLRVFTKP---EAKLLNNRIIKRLENSEMNFACKVTGYPLP-DVTWIFSNDE 328
L +N +++L V P E + + I R +S C G PLP + W +
Sbjct: 407 GLRRNISLELVVNVPPQIHEKEASSPSIYSR--HSRQALTCTAYGVPLPLSIQWHWRPWT 464
Query: 329 EHELSSTKSEQESLYAKTDYLKISVQASGVITCNAHNSKGEYFDSSTLLVYEINNGFGIL 388
++ + +S + + D + V T +A N E D+ T V N L
Sbjct: 465 PCKMFAQRSLRRR--QQQDLMPQCRDWRAVTTQDAVNPI-ESLDTWTEFVEGKNKTVSKL 521
Query: 389 QPLENWYSEKDSARKKCLASVYDYDNVSWLGSDGNILDDIELLAPIIREPDSNKDEEAME 448
++N SA KC+ S + +G D ++ P +S EE +E
Sbjct: 522 -VIQN---ANVSAMYKCVVS-------NKVGQDERLIYFYVTTIPDGFTIESKPSEELLE 570
Query: 449 GRSIQLHCEAEGVPRPTIYWYK-DDELISNNSGYKLFVDIVN 489
G+ + L C+A+ + WY+ + + + G L +D N
Sbjct: 571 GQPVLLSCQADSYKYEHLRWYRLNLSTLHDAHGNPLLLDCKN 612
>X69878-1|CAA49505.1| 1298|Homo sapiens protein ( H.sapiens Flt4 mRNA
for transmembrane tyrosine kinase. ).
Length = 1298
Score = 191 bits (466), Expect = 1e-47
Identities = 82/167 (49%), Positives = 124/167 (74%), Gaps = 1/167 (0%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
PLT L+ ++FQ+ARGME+LA+RK +H DLAARN+LL++ +VVKICDFGLAR +Y + +
Sbjct: 1008 PLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPD 1067
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS-PTDLLRW 914
Y +K ++ LP+KW+A E + D++++TQSDVWS+G++LWE+FSL +PYP + + +
Sbjct: 1068 YVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQR 1127
Query: 915 LSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
+ DG R+ P A + ++ML CW P ARP+F++L EILG+ L+
Sbjct: 1128 VRDGTRMRAPELATPAIRHIMLNCWSGDPKARPAFSDLVEILGDLLQ 1174
Score = 146 bits (354), Expect = 4e-34
Identities = 92/267 (34%), Positives = 142/267 (53%), Gaps = 19/267 (7%)
Query: 451 SIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIY 510
S+++ C G P+I WYKD+ L+ SG VD+ + N I+ ++E+D G Y
Sbjct: 694 SLEMQCLVAGAHAPSIVWYKDERLLEEKSG----VDLADS---NQKLSIQRVREEDAGPY 746
Query: 511 ECVALNNASELRRAYTLVLKAEKSYTPYXXXXXXXXXXXXGMVAYLFTWKLKKQR--ELT 568
C + + ++ ++ + G++A F W L +
Sbjct: 747 LCSVCRPKGCVNSSASVAVEGSED----KGSMEIVILVGTGVIAVFF-WVLLLLIFCNMR 801
Query: 569 KAGLLNFKSGNKKSF-NPN-LGIDEQADLLPYD-EKFEFPREKLTFGKQLGAGAFGVVYK 625
+ + K+G +P + ++EQ + L YD ++EFPRE+L G+ LG GAFG V +
Sbjct: 802 RPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVE 861
Query: 626 AEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIA 685
A A GI VAVKM+K A +AL SELKI++H+G H+N+VNLLGACTK
Sbjct: 862 ASAFGIHKGSSCDTVAVKMLKEGATASEQRALMSELKILIHIGNHLNVVNLLGACTK--P 919
Query: 686 KRELIVIVEYCKYGNIHNYMQKHREVF 712
+ L+VIVE+CKYGN+ N+++ R+ F
Sbjct: 920 QGPLMVIVEFCKYGNLSNFLRAKRDAF 946
Score = 52.8 bits (121), Expect = 7e-06
Identities = 92/402 (22%), Positives = 158/402 (39%), Gaps = 41/402 (10%)
Query: 99 QFLEGETFTIHCRVP---NDGLINFKWKYPPEVTNDSVEVSVVKTEATTTGSIVYQNITI 155
+ L GE ++C V N G + F W YP + V +++ T T + +TI
Sbjct: 241 ELLVGEKLVLNCTVWAEFNSG-VTFDWDYPGKQAERGKWVPERRSQQTHTE--LSSILTI 297
Query: 156 RNATKKHNGVYTCLLTNTCGEEKDEFRKIFLEKPFLSLRDLAKGKLMGNA-NKSINIVIE 214
N ++ G Y C N ++ I E PF+S+ L L A ++ + + ++
Sbjct: 298 HNVSQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLPVK 357
Query: 215 IEAYPPVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKY- 273
+ AYPP E + K+ K L + L + ++ YTL N
Sbjct: 358 LAAYPPPE-FQWYKDGKALSGR----------HSPHALVLKEVTEASTGTYTLALWNSAA 406
Query: 274 -LTKNYTVDLRVFTKP---EAKLLNNRIIKRLENSEMNFACKVTGYPLP-DVTWIFSNDE 328
L +N +++L V P E + + I R +S C G PLP + W +
Sbjct: 407 GLRRNISLELVVNVPPQIHEKEASSPSIYSR--HSRQALTCTAYGVPLPLSIQWHWRPWT 464
Query: 329 EHELSSTKSEQESLYAKTDYLKISVQASGVITCNAHNSKGEYFDSSTLLVYEINNGFGIL 388
++ + +S + + D + V T +A N E D+ T V N L
Sbjct: 465 PCKMFAQRSLRRR--QQQDLMPQCRDWRAVTTQDAVNPI-ESLDTWTEFVEGKNKTVSKL 521
Query: 389 QPLENWYSEKDSARKKCLASVYDYDNVSWLGSDGNILDDIELLAPIIREPDSNKDEEAME 448
++N SA KC+ S + +G D ++ P +S EE +E
Sbjct: 522 -VIQN---ANVSAMYKCVVS-------NKVGQDERLIYFYVTTIPDGFTIESKPSEELLE 570
Query: 449 GRSIQLHCEAEGVPRPTIYWYK-DDELISNNSGYKLFVDIVN 489
G+ + L C+A+ + WY+ + + + G L +D N
Sbjct: 571 GQPVLLSCQADSYKYEHLRWYRLNLSTLHDAHGNPLLLDCKN 612
>Z71929-1|CAA96492.1| 821|Homo sapiens FGFR2 protein.
Length = 821
Score = 190 bits (463), Expect = 2e-47
Identities = 85/194 (43%), Positives = 129/194 (66%), Gaps = 2/194 (1%)
Query: 786 DYIYECHQ--PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y+ ++ +T L+ +Q+ARGMEYLA++K +H DLAARNVL+ ++NV+KI D
Sbjct: 585 EYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIAD 644
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR + N + Y+K N LPVKW+A E + DR+++ QSDVWS+G+++WE+F+L +PY
Sbjct: 645 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 704
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P I +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L L
Sbjct: 705 PGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLT 764
Query: 964 ERNRYVDLNAPYNE 977
Y+DL+ P +
Sbjct: 765 TNEEYLDLSQPLEQ 778
Score = 102 bits (244), Expect = 9e-21
Identities = 57/116 (49%), Positives = 71/116 (61%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGI--INAEVTTPVAVKMVKRTADNMY 653
LP D K+EFPR+KLT GK LG G FG V AEA GI + VAVKM+K A
Sbjct: 468 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 527
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y++ R
Sbjct: 528 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLRARR 580
Score = 36.7 bits (81), Expect = 0.48
Identities = 38/145 (26%), Positives = 64/145 (44%), Gaps = 14/145 (9%)
Query: 220 PVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYT 279
P+ +LKN K + + + N L + + +D NYT V EN+Y + N+T
Sbjct: 185 PMPTMRWLKNGKEF-KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHT 243
Query: 280 VDLRVFTK-PEAKLLNNRI---IKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSST 335
L V + P +L + + ++ F CKV P + WI + E + +
Sbjct: 244 YHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI----KHVEKNGS 299
Query: 336 KSEQESLYAKTDYLKISVQASGVIT 360
K + L YLK+ ++A+GV T
Sbjct: 300 KYGPDGL----PYLKV-LKAAGVNT 319
Score = 33.9 bits (74), Expect = 3.4
Identities = 35/140 (25%), Positives = 55/140 (39%), Gaps = 22/140 (15%)
Query: 414 NVSWLGSDGNILDDIELLAPIIREPDSNK------DEEAMEGR--------SIQLHCEAE 459
NV+ S G+ DD + + E +NK + E ME R +++ C A
Sbjct: 123 NVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAG 182
Query: 460 GVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDNGIYECVALNN 517
G P PT+ W K N +K I + + N + + E++ D G Y CV N
Sbjct: 183 GNPMPTMRWLK------NGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE 236
Query: 518 ASELRRAYTLVLKAEKSYTP 537
+ Y L + + P
Sbjct: 237 YGSINHTYHLDVVERSPHRP 256
>X52832-1|CAA37014.1| 821|Homo sapiens protein ( Human bek mRNA for
fibroblast growth factor receptor-BEK. ).
Length = 821
Score = 190 bits (463), Expect = 2e-47
Identities = 85/194 (43%), Positives = 129/194 (66%), Gaps = 2/194 (1%)
Query: 786 DYIYECHQ--PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y+ ++ +T L+ +Q+ARGMEYLA++K +H DLAARNVL+ ++NV+KI D
Sbjct: 585 EYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIAD 644
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR + N + Y+K N LPVKW+A E + DR+++ QSDVWS+G+++WE+F+L +PY
Sbjct: 645 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 704
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P I +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L L
Sbjct: 705 PGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLT 764
Query: 964 ERNRYVDLNAPYNE 977
Y+DL+ P +
Sbjct: 765 TNEEYLDLSQPLEQ 778
Score = 102 bits (244), Expect = 9e-21
Identities = 57/116 (49%), Positives = 71/116 (61%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGI--INAEVTTPVAVKMVKRTADNMY 653
LP D K+EFPR+KLT GK LG G FG V AEA GI + VAVKM+K A
Sbjct: 468 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 527
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y++ R
Sbjct: 528 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLRARR 580
Score = 36.7 bits (81), Expect = 0.48
Identities = 38/145 (26%), Positives = 64/145 (44%), Gaps = 14/145 (9%)
Query: 220 PVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYT 279
P+ +LKN K + + + N L + + +D NYT V EN+Y + N+T
Sbjct: 185 PMPTMRWLKNGKEF-KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHT 243
Query: 280 VDLRVFTK-PEAKLLNNRI---IKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSST 335
L V + P +L + + ++ F CKV P + WI + E + +
Sbjct: 244 YHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI----KHVEKNGS 299
Query: 336 KSEQESLYAKTDYLKISVQASGVIT 360
K + L YLK+ ++A+GV T
Sbjct: 300 KYGPDGL----PYLKV-LKAAGVNT 319
Score = 33.9 bits (74), Expect = 3.4
Identities = 35/140 (25%), Positives = 55/140 (39%), Gaps = 22/140 (15%)
Query: 414 NVSWLGSDGNILDDIELLAPIIREPDSNK------DEEAMEGR--------SIQLHCEAE 459
NV+ S G+ DD + + E +NK + E ME R +++ C A
Sbjct: 123 NVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAG 182
Query: 460 GVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDNGIYECVALNN 517
G P PT+ W K N +K I + + N + + E++ D G Y CV N
Sbjct: 183 GNPMPTMRWLK------NGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE 236
Query: 518 ASELRRAYTLVLKAEKSYTP 537
+ Y L + + P
Sbjct: 237 YGSINHTYHLDVVERSPHRP 256
>M97193-1|AAA52449.1| 822|Homo sapiens fibroblast growth factor
receptor 2 protein.
Length = 822
Score = 190 bits (463), Expect = 2e-47
Identities = 85/194 (43%), Positives = 129/194 (66%), Gaps = 2/194 (1%)
Query: 786 DYIYECHQ--PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y+ ++ +T L+ +Q+ARGMEYLA++K +H DLAARNVL+ ++NV+KI D
Sbjct: 586 EYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIAD 645
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR + N + Y+K N LPVKW+A E + DR+++ QSDVWS+G+++WE+F+L +PY
Sbjct: 646 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 705
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P I +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L L
Sbjct: 706 PGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLT 765
Query: 964 ERNRYVDLNAPYNE 977
Y+DL+ P +
Sbjct: 766 TNEEYLDLSQPLEQ 779
Score = 102 bits (244), Expect = 9e-21
Identities = 57/116 (49%), Positives = 71/116 (61%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGI--INAEVTTPVAVKMVKRTADNMY 653
LP D K+EFPR+KLT GK LG G FG V AEA GI + VAVKM+K A
Sbjct: 469 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 528
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y++ R
Sbjct: 529 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLRARR 581
Score = 37.1 bits (82), Expect = 0.37
Identities = 38/148 (25%), Positives = 65/148 (43%), Gaps = 14/148 (9%)
Query: 220 PVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYT 279
P+ +LKN K + + + N L + + +D NYT V EN+Y + N+T
Sbjct: 185 PMPTMRWLKNGKEF-KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHT 243
Query: 280 VDLRVFTK-PEAKLLNNRI---IKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSST 335
L V + P +L + + ++ F CKV P + WI + E + +
Sbjct: 244 YHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI----KHVEKNGS 299
Query: 336 KSEQESLYAKTDYLKISVQASGVITCNA 363
K + L YLK+ ++ SG+ + NA
Sbjct: 300 KYGPDGL----PYLKV-LKHSGINSSNA 322
Score = 33.9 bits (74), Expect = 3.4
Identities = 35/140 (25%), Positives = 55/140 (39%), Gaps = 22/140 (15%)
Query: 414 NVSWLGSDGNILDDIELLAPIIREPDSNK------DEEAMEGR--------SIQLHCEAE 459
NV+ S G+ DD + + E +NK + E ME R +++ C A
Sbjct: 123 NVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAG 182
Query: 460 GVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDNGIYECVALNN 517
G P PT+ W K N +K I + + N + + E++ D G Y CV N
Sbjct: 183 GNPMPTMRWLK------NGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE 236
Query: 518 ASELRRAYTLVLKAEKSYTP 537
+ Y L + + P
Sbjct: 237 YGSINHTYHLDVVERSPHRP 256
>M87771-1|AAA59471.1| 705|Homo sapiens fibroblast growth factor
receptor protein.
Length = 705
Score = 190 bits (463), Expect = 2e-47
Identities = 85/194 (43%), Positives = 129/194 (66%), Gaps = 2/194 (1%)
Query: 786 DYIYECHQ--PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y+ ++ +T L+ +Q+ARGMEYLA++K +H DLAARNVL+ ++NV+KI D
Sbjct: 469 EYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIAD 528
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR + N + Y+K N LPVKW+A E + DR+++ QSDVWS+G+++WE+F+L +PY
Sbjct: 529 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 588
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P I +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L L
Sbjct: 589 PGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLT 648
Query: 964 ERNRYVDLNAPYNE 977
Y+DL+ P +
Sbjct: 649 TNEEYLDLSQPLEQ 662
Score = 102 bits (244), Expect = 9e-21
Identities = 57/116 (49%), Positives = 71/116 (61%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGI--INAEVTTPVAVKMVKRTADNMY 653
LP D K+EFPR+KLT GK LG G FG V AEA GI + VAVKM+K A
Sbjct: 352 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 411
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y++ R
Sbjct: 412 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLRARR 464
Score = 38.7 bits (86), Expect = 0.12
Identities = 38/148 (25%), Positives = 64/148 (43%), Gaps = 12/148 (8%)
Query: 220 PVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYT 279
P+ +LKN K + + + N L + + +D NYT V EN+Y + N+T
Sbjct: 185 PMPTMRWLKNGKEF-KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHT 243
Query: 280 VDLRVFTK-PEAKLLNNRI---IKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSST 335
L V + P +L + + ++ F CKV P + WI + E + +
Sbjct: 244 YHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI----KHVEKNGS 299
Query: 336 KSEQESL-YAKTDYLKISVQASGVITCN 362
K + L Y K LK+S ++S + N
Sbjct: 300 KYGPDGLPYLKV--LKVSAESSSSMNSN 325
Score = 33.9 bits (74), Expect = 3.4
Identities = 35/140 (25%), Positives = 55/140 (39%), Gaps = 22/140 (15%)
Query: 414 NVSWLGSDGNILDDIELLAPIIREPDSNK------DEEAMEGR--------SIQLHCEAE 459
NV+ S G+ DD + + E +NK + E ME R +++ C A
Sbjct: 123 NVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAG 182
Query: 460 GVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDNGIYECVALNN 517
G P PT+ W K N +K I + + N + + E++ D G Y CV N
Sbjct: 183 GNPMPTMRWLK------NGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE 236
Query: 518 ASELRRAYTLVLKAEKSYTP 537
+ Y L + + P
Sbjct: 237 YGSINHTYHLDVVERSPHRP 256
>M87770-1|AAA59470.1| 821|Homo sapiens fibroblast growth factor
receptor protein.
Length = 821
Score = 190 bits (463), Expect = 2e-47
Identities = 85/194 (43%), Positives = 129/194 (66%), Gaps = 2/194 (1%)
Query: 786 DYIYECHQ--PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y+ ++ +T L+ +Q+ARGMEYLA++K +H DLAARNVL+ ++NV+KI D
Sbjct: 585 EYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIAD 644
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR + N + Y+K N LPVKW+A E + DR+++ QSDVWS+G+++WE+F+L +PY
Sbjct: 645 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 704
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P I +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L L
Sbjct: 705 PGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLT 764
Query: 964 ERNRYVDLNAPYNE 977
Y+DL+ P +
Sbjct: 765 TNEEYLDLSQPLEQ 778
Score = 102 bits (244), Expect = 9e-21
Identities = 57/116 (49%), Positives = 71/116 (61%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGI--INAEVTTPVAVKMVKRTADNMY 653
LP D K+EFPR+KLT GK LG G FG V AEA GI + VAVKM+K A
Sbjct: 468 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 527
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y++ R
Sbjct: 528 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLRARR 580
Score = 36.7 bits (81), Expect = 0.48
Identities = 38/145 (26%), Positives = 64/145 (44%), Gaps = 14/145 (9%)
Query: 220 PVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYT 279
P+ +LKN K + + + N L + + +D NYT V EN+Y + N+T
Sbjct: 185 PMPTMRWLKNGKEF-KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHT 243
Query: 280 VDLRVFTK-PEAKLLNNRI---IKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSST 335
L V + P +L + + ++ F CKV P + WI + E + +
Sbjct: 244 YHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI----KHVEKNGS 299
Query: 336 KSEQESLYAKTDYLKISVQASGVIT 360
K + L YLK+ ++A+GV T
Sbjct: 300 KYGPDGL----PYLKV-LKAAGVNT 319
Score = 33.9 bits (74), Expect = 3.4
Identities = 35/140 (25%), Positives = 55/140 (39%), Gaps = 22/140 (15%)
Query: 414 NVSWLGSDGNILDDIELLAPIIREPDSNK------DEEAMEGR--------SIQLHCEAE 459
NV+ S G+ DD + + E +NK + E ME R +++ C A
Sbjct: 123 NVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAG 182
Query: 460 GVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDNGIYECVALNN 517
G P PT+ W K N +K I + + N + + E++ D G Y CV N
Sbjct: 183 GNPMPTMRWLK------NGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE 236
Query: 518 ASELRRAYTLVLKAEKSYTP 537
+ Y L + + P
Sbjct: 237 YGSINHTYHLDVVERSPHRP 256
>M55614-1|AAA61188.1| 822|Homo sapiens TK14 protein protein.
Length = 822
Score = 190 bits (463), Expect = 2e-47
Identities = 85/194 (43%), Positives = 129/194 (66%), Gaps = 2/194 (1%)
Query: 786 DYIYECHQ--PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y+ ++ +T L+ +Q+ARGMEYLA++K +H DLAARNVL+ ++NV+KI D
Sbjct: 586 EYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIAD 645
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR + N + Y+K N LPVKW+A E + DR+++ QSDVWS+G+++WE+F+L +PY
Sbjct: 646 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 705
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P I +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L L
Sbjct: 706 PGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLT 765
Query: 964 ERNRYVDLNAPYNE 977
Y+DL+ P +
Sbjct: 766 TNEEYLDLSQPLEQ 779
Score = 102 bits (244), Expect = 9e-21
Identities = 57/116 (49%), Positives = 71/116 (61%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGI--INAEVTTPVAVKMVKRTADNMY 653
LP D K+EFPR+KLT GK LG G FG V AEA GI + VAVKM+K A
Sbjct: 469 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 528
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y++ R
Sbjct: 529 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLRARR 581
Score = 36.3 bits (80), Expect = 0.64
Identities = 28/108 (25%), Positives = 46/108 (42%), Gaps = 5/108 (4%)
Query: 220 PVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYT 279
P+ +LKN K + + + N L + + +D NYT V EN+Y + N+T
Sbjct: 185 PMPTMRWLKNGKEF-KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHT 243
Query: 280 VDLRVFTK-PEAKLLNNRI---IKRLENSEMNFACKVTGYPLPDVTWI 323
L V + P +L + + ++ F CKV P + WI
Sbjct: 244 YHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI 291
Score = 33.9 bits (74), Expect = 3.4
Identities = 35/140 (25%), Positives = 55/140 (39%), Gaps = 22/140 (15%)
Query: 414 NVSWLGSDGNILDDIELLAPIIREPDSNK------DEEAMEGR--------SIQLHCEAE 459
NV+ S G+ DD + + E +NK + E ME R +++ C A
Sbjct: 123 NVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAG 182
Query: 460 GVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDNGIYECVALNN 517
G P PT+ W K N +K I + + N + + E++ D G Y CV N
Sbjct: 183 GNPMPTMRWLK------NGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE 236
Query: 518 ASELRRAYTLVLKAEKSYTP 537
+ Y L + + P
Sbjct: 237 YGSINHTYHLDVVERSPHRP 256
>BC039243-1|AAH39243.2| 704|Homo sapiens FGFR2 protein protein.
Length = 704
Score = 190 bits (463), Expect = 2e-47
Identities = 85/194 (43%), Positives = 129/194 (66%), Gaps = 2/194 (1%)
Query: 786 DYIYECHQ--PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y+ ++ +T L+ +Q+ARGMEYLA++K +H DLAARNVL+ ++NV+KI D
Sbjct: 468 EYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIAD 527
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR + N + Y+K N LPVKW+A E + DR+++ QSDVWS+G+++WE+F+L +PY
Sbjct: 528 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 587
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P I +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L L
Sbjct: 588 PGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLT 647
Query: 964 ERNRYVDLNAPYNE 977
Y+DL+ P +
Sbjct: 648 TNEEYLDLSQPLEQ 661
Score = 102 bits (244), Expect = 9e-21
Identities = 57/116 (49%), Positives = 71/116 (61%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGI--INAEVTTPVAVKMVKRTADNMY 653
LP D K+EFPR+KLT GK LG G FG V AEA GI + VAVKM+K A
Sbjct: 351 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 410
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y++ R
Sbjct: 411 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLRARR 463
Score = 36.7 bits (81), Expect = 0.48
Identities = 38/145 (26%), Positives = 64/145 (44%), Gaps = 14/145 (9%)
Query: 220 PVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYT 279
P+ +LKN K + + + N L + + +D NYT V EN+Y + N+T
Sbjct: 70 PMPTMRWLKNGKEF-KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHT 128
Query: 280 VDLRVFTK-PEAKLLNNRI---IKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSST 335
L V + P +L + + ++ F CKV P + WI + E + +
Sbjct: 129 YHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI----KHVEKNGS 184
Query: 336 KSEQESLYAKTDYLKISVQASGVIT 360
K + L YLK+ ++A+GV T
Sbjct: 185 KYGPDGL----PYLKV-LKAAGVNT 204
Score = 33.5 bits (73), Expect = 4.5
Identities = 22/89 (24%), Positives = 36/89 (40%), Gaps = 8/89 (8%)
Query: 451 SIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDNG 508
+++ C A G P PT+ W K N +K I + + N + + E++ D G
Sbjct: 59 TVKFRCPAGGNPMPTMRWLK------NGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKG 112
Query: 509 IYECVALNNASELRRAYTLVLKAEKSYTP 537
Y CV N + Y L + + P
Sbjct: 113 NYTCVVENEYGSINHTYHLDVVERSPHRP 141
>AF487553-1|AAM74056.1| 822|Homo sapiens fibroblast growth factor
receptor 2 protein.
Length = 822
Score = 190 bits (463), Expect = 2e-47
Identities = 85/194 (43%), Positives = 129/194 (66%), Gaps = 2/194 (1%)
Query: 786 DYIYECHQ--PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y+ ++ +T L+ +Q+ARGMEYLA++K +H DLAARNVL+ ++NV+KI D
Sbjct: 586 EYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIAD 645
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR + N + Y+K N LPVKW+A E + DR+++ QSDVWS+G+++WE+F+L +PY
Sbjct: 646 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 705
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P I +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L L
Sbjct: 706 PGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLT 765
Query: 964 ERNRYVDLNAPYNE 977
Y+DL+ P +
Sbjct: 766 TNEEYLDLSQPLEQ 779
Score = 102 bits (244), Expect = 9e-21
Identities = 57/116 (49%), Positives = 71/116 (61%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGI--INAEVTTPVAVKMVKRTADNMY 653
LP D K+EFPR+KLT GK LG G FG V AEA GI + VAVKM+K A
Sbjct: 469 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 528
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y++ R
Sbjct: 529 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLRARR 581
Score = 37.1 bits (82), Expect = 0.37
Identities = 38/148 (25%), Positives = 65/148 (43%), Gaps = 14/148 (9%)
Query: 220 PVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYT 279
P+ +LKN K + + + N L + + +D NYT V EN+Y + N+T
Sbjct: 185 PMPTMRWLKNGKEF-KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHT 243
Query: 280 VDLRVFTK-PEAKLLNNRI---IKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSST 335
L V + P +L + + ++ F CKV P + WI + E + +
Sbjct: 244 YHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI----KHVEKNGS 299
Query: 336 KSEQESLYAKTDYLKISVQASGVITCNA 363
K + L YLK+ ++ SG+ + NA
Sbjct: 300 KYGPDGL----PYLKV-LKHSGINSSNA 322
Score = 33.9 bits (74), Expect = 3.4
Identities = 35/140 (25%), Positives = 55/140 (39%), Gaps = 22/140 (15%)
Query: 414 NVSWLGSDGNILDDIELLAPIIREPDSNK------DEEAMEGR--------SIQLHCEAE 459
NV+ S G+ DD + + E +NK + E ME R +++ C A
Sbjct: 123 NVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAG 182
Query: 460 GVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDNGIYECVALNN 517
G P PT+ W K N +K I + + N + + E++ D G Y CV N
Sbjct: 183 GNPMPTMRWLK------NGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE 236
Query: 518 ASELRRAYTLVLKAEKSYTP 537
+ Y L + + P
Sbjct: 237 YGSINHTYHLDVVERSPHRP 256
>AF360695-2|AAK94205.1| 819|Homo sapiens keratinocyte growth factor
receptor 2 isoform BEK protein.
Length = 819
Score = 190 bits (463), Expect = 2e-47
Identities = 85/194 (43%), Positives = 129/194 (66%), Gaps = 2/194 (1%)
Query: 786 DYIYECHQ--PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y+ ++ +T L+ +Q+ARGMEYLA++K +H DLAARNVL+ ++NV+KI D
Sbjct: 583 EYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIAD 642
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR + N + Y+K N LPVKW+A E + DR+++ QSDVWS+G+++WE+F+L +PY
Sbjct: 643 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 702
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P I +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L L
Sbjct: 703 PGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLT 762
Query: 964 ERNRYVDLNAPYNE 977
Y+DL+ P +
Sbjct: 763 TNEEYLDLSQPLEQ 776
Score = 102 bits (244), Expect = 9e-21
Identities = 57/116 (49%), Positives = 71/116 (61%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGI--INAEVTTPVAVKMVKRTADNMY 653
LP D K+EFPR+KLT GK LG G FG V AEA GI + VAVKM+K A
Sbjct: 466 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 525
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y++ R
Sbjct: 526 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLRARR 578
Score = 36.7 bits (81), Expect = 0.48
Identities = 38/145 (26%), Positives = 64/145 (44%), Gaps = 14/145 (9%)
Query: 220 PVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYT 279
P+ +LKN K + + + N L + + +D NYT V EN+Y + N+T
Sbjct: 185 PMPTMRWLKNGKEF-KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHT 243
Query: 280 VDLRVFTK-PEAKLLNNRI---IKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSST 335
L V + P +L + + ++ F CKV P + WI + E + +
Sbjct: 244 YHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI----KHVEKNGS 299
Query: 336 KSEQESLYAKTDYLKISVQASGVIT 360
K + L YLK+ ++A+GV T
Sbjct: 300 KYGPDGL----PYLKV-LKAAGVNT 319
Score = 33.9 bits (74), Expect = 3.4
Identities = 35/140 (25%), Positives = 55/140 (39%), Gaps = 22/140 (15%)
Query: 414 NVSWLGSDGNILDDIELLAPIIREPDSNK------DEEAMEGR--------SIQLHCEAE 459
NV+ S G+ DD + + E +NK + E ME R +++ C A
Sbjct: 123 NVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAG 182
Query: 460 GVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDNGIYECVALNN 517
G P PT+ W K N +K I + + N + + E++ D G Y CV N
Sbjct: 183 GNPMPTMRWLK------NGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE 236
Query: 518 ASELRRAYTLVLKAEKSYTP 537
+ Y L + + P
Sbjct: 237 YGSINHTYHLDVVERSPHRP 256
>AF360695-1|AAK94206.1| 820|Homo sapiens keratinocyte growth factor
receptor 2 isoform KGFR protein.
Length = 820
Score = 190 bits (463), Expect = 2e-47
Identities = 85/194 (43%), Positives = 129/194 (66%), Gaps = 2/194 (1%)
Query: 786 DYIYECHQ--PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y+ ++ +T L+ +Q+ARGMEYLA++K +H DLAARNVL+ ++NV+KI D
Sbjct: 584 EYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIAD 643
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR + N + Y+K N LPVKW+A E + DR+++ QSDVWS+G+++WE+F+L +PY
Sbjct: 644 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 703
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P I +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L L
Sbjct: 704 PGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLT 763
Query: 964 ERNRYVDLNAPYNE 977
Y+DL+ P +
Sbjct: 764 TNEEYLDLSQPLEQ 777
Score = 102 bits (244), Expect = 9e-21
Identities = 57/116 (49%), Positives = 71/116 (61%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGI--INAEVTTPVAVKMVKRTADNMY 653
LP D K+EFPR+KLT GK LG G FG V AEA GI + VAVKM+K A
Sbjct: 467 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 526
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y++ R
Sbjct: 527 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLRARR 579
Score = 37.1 bits (82), Expect = 0.37
Identities = 38/148 (25%), Positives = 65/148 (43%), Gaps = 14/148 (9%)
Query: 220 PVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYT 279
P+ +LKN K + + + N L + + +D NYT V EN+Y + N+T
Sbjct: 185 PMPTMRWLKNGKEF-KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHT 243
Query: 280 VDLRVFTK-PEAKLLNNRI---IKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSST 335
L V + P +L + + ++ F CKV P + WI + E + +
Sbjct: 244 YHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI----KHVEKNGS 299
Query: 336 KSEQESLYAKTDYLKISVQASGVITCNA 363
K + L YLK+ ++ SG+ + NA
Sbjct: 300 KYGPDGL----PYLKV-LKHSGINSSNA 322
Score = 33.9 bits (74), Expect = 3.4
Identities = 35/140 (25%), Positives = 55/140 (39%), Gaps = 22/140 (15%)
Query: 414 NVSWLGSDGNILDDIELLAPIIREPDSNK------DEEAMEGR--------SIQLHCEAE 459
NV+ S G+ DD + + E +NK + E ME R +++ C A
Sbjct: 123 NVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAG 182
Query: 460 GVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDNGIYECVALNN 517
G P PT+ W K N +K I + + N + + E++ D G Y CV N
Sbjct: 183 GNPMPTMRWLK------NGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE 236
Query: 518 ASELRRAYTLVLKAEKSYTP 537
+ Y L + + P
Sbjct: 237 YGSINHTYHLDVVERSPHRP 256
>AB084153-1|BAC45037.1| 709|Homo sapiens isoform of FGFR2 protein.
Length = 709
Score = 190 bits (463), Expect = 2e-47
Identities = 85/194 (43%), Positives = 129/194 (66%), Gaps = 2/194 (1%)
Query: 786 DYIYECHQ--PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y+ ++ +T L+ +Q+ARGMEYLA++K +H DLAARNVL+ ++NV+KI D
Sbjct: 473 EYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIAD 532
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR + N + Y+K N LPVKW+A E + DR+++ QSDVWS+G+++WE+F+L +PY
Sbjct: 533 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 592
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P I +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L L
Sbjct: 593 PGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLT 652
Query: 964 ERNRYVDLNAPYNE 977
Y+DL+ P +
Sbjct: 653 TNEEYLDLSQPLEQ 666
Score = 102 bits (244), Expect = 9e-21
Identities = 57/116 (49%), Positives = 71/116 (61%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGI--INAEVTTPVAVKMVKRTADNMY 653
LP D K+EFPR+KLT GK LG G FG V AEA GI + VAVKM+K A
Sbjct: 356 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 415
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y++ R
Sbjct: 416 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLRARR 468
Score = 33.1 bits (72), Expect = 5.9
Identities = 34/130 (26%), Positives = 52/130 (40%), Gaps = 22/130 (16%)
Query: 414 NVSWLGSDGNILDDIELLAPIIREPDSNK------DEEAMEGR--------SIQLHCEAE 459
NV+ S G+ DD + + E +NK + E ME R +++ C A
Sbjct: 123 NVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAG 182
Query: 460 GVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDNGIYECVALNN 517
G P PT+ W K N +K I + + N + + E++ D G Y CV N
Sbjct: 183 GNPMPTMRWLK------NGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE 236
Query: 518 ASELRRAYTL 527
+ Y L
Sbjct: 237 YGSINHTYHL 246
>DQ493927-1|ABE96832.1| 785|Homo sapiens fibroblast growth factor
receptor 2 (bacteria-expressed kinase, keratinocyte gr
protein.
Length = 785
Score = 190 bits (462), Expect = 3e-47
Identities = 85/191 (44%), Positives = 128/191 (67%), Gaps = 2/191 (1%)
Query: 786 DYIYECHQ--PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y+ ++ +T L+ +Q+ARGMEYLA++K +H DLAARNVL+ ++NV+KI D
Sbjct: 583 EYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIAD 642
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR + N + Y+K N LPVKW+A E + DR+++ QSDVWS+G+++WE+F+L +PY
Sbjct: 643 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 702
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P I +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L L
Sbjct: 703 PGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLT 762
Query: 964 ERNRYVDLNAP 974
Y+DL+ P
Sbjct: 763 TNEEYLDLSQP 773
Score = 102 bits (244), Expect = 9e-21
Identities = 57/116 (49%), Positives = 71/116 (61%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGI--INAEVTTPVAVKMVKRTADNMY 653
LP D K+EFPR+KLT GK LG G FG V AEA GI + VAVKM+K A
Sbjct: 466 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 525
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y++ R
Sbjct: 526 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLRARR 578
Score = 36.7 bits (81), Expect = 0.48
Identities = 38/145 (26%), Positives = 64/145 (44%), Gaps = 14/145 (9%)
Query: 220 PVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYT 279
P+ +LKN K + + + N L + + +D NYT V EN+Y + N+T
Sbjct: 185 PMPTMRWLKNGKEF-KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHT 243
Query: 280 VDLRVFTK-PEAKLLNNRI---IKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSST 335
L V + P +L + + ++ F CKV P + WI + E + +
Sbjct: 244 YHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI----KHVEKNGS 299
Query: 336 KSEQESLYAKTDYLKISVQASGVIT 360
K + L YLK+ ++A+GV T
Sbjct: 300 KYGPDGL----PYLKV-LKAAGVNT 319
Score = 33.9 bits (74), Expect = 3.4
Identities = 35/140 (25%), Positives = 55/140 (39%), Gaps = 22/140 (15%)
Query: 414 NVSWLGSDGNILDDIELLAPIIREPDSNK------DEEAMEGR--------SIQLHCEAE 459
NV+ S G+ DD + + E +NK + E ME R +++ C A
Sbjct: 123 NVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAG 182
Query: 460 GVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDNGIYECVALNN 517
G P PT+ W K N +K I + + N + + E++ D G Y CV N
Sbjct: 183 GNPMPTMRWLK------NGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE 236
Query: 518 ASELRRAYTLVLKAEKSYTP 537
+ Y L + + P
Sbjct: 237 YGSINHTYHLDVVERSPHRP 256
>AF360695-3|AAK94209.1| 785|Homo sapiens keratinocyte growth factor
receptor 2 isoform K-sam-IIC2 protein.
Length = 785
Score = 190 bits (462), Expect = 3e-47
Identities = 85/191 (44%), Positives = 128/191 (67%), Gaps = 2/191 (1%)
Query: 786 DYIYECHQ--PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y+ ++ +T L+ +Q+ARGMEYLA++K +H DLAARNVL+ ++NV+KI D
Sbjct: 583 EYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIAD 642
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR + N + Y+K N LPVKW+A E + DR+++ QSDVWS+G+++WE+F+L +PY
Sbjct: 643 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 702
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P I +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L L
Sbjct: 703 PGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLT 762
Query: 964 ERNRYVDLNAP 974
Y+DL+ P
Sbjct: 763 TNEEYLDLSQP 773
Score = 102 bits (244), Expect = 9e-21
Identities = 57/116 (49%), Positives = 71/116 (61%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGI--INAEVTTPVAVKMVKRTADNMY 653
LP D K+EFPR+KLT GK LG G FG V AEA GI + VAVKM+K A
Sbjct: 466 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 525
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y++ R
Sbjct: 526 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLRARR 578
Score = 36.7 bits (81), Expect = 0.48
Identities = 38/145 (26%), Positives = 64/145 (44%), Gaps = 14/145 (9%)
Query: 220 PVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYT 279
P+ +LKN K + + + N L + + +D NYT V EN+Y + N+T
Sbjct: 185 PMPTMRWLKNGKEF-KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHT 243
Query: 280 VDLRVFTK-PEAKLLNNRI---IKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSST 335
L V + P +L + + ++ F CKV P + WI + E + +
Sbjct: 244 YHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI----KHVEKNGS 299
Query: 336 KSEQESLYAKTDYLKISVQASGVIT 360
K + L YLK+ ++A+GV T
Sbjct: 300 KYGPDGL----PYLKV-LKAAGVNT 319
Score = 33.9 bits (74), Expect = 3.4
Identities = 35/140 (25%), Positives = 55/140 (39%), Gaps = 22/140 (15%)
Query: 414 NVSWLGSDGNILDDIELLAPIIREPDSNK------DEEAMEGR--------SIQLHCEAE 459
NV+ S G+ DD + + E +NK + E ME R +++ C A
Sbjct: 123 NVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAG 182
Query: 460 GVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDNGIYECVALNN 517
G P PT+ W K N +K I + + N + + E++ D G Y CV N
Sbjct: 183 GNPMPTMRWLK------NGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE 236
Query: 518 ASELRRAYTLVLKAEKSYTP 537
+ Y L + + P
Sbjct: 237 YGSINHTYHLDVVERSPHRP 256
>Y13901-1|CAA74200.1| 802|Homo sapiens fibroblast growth factor 4
protein.
Length = 802
Score = 189 bits (460), Expect = 6e-47
Identities = 82/165 (49%), Positives = 117/165 (70%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
PL+ L+ A+Q+ARGM+YL +RK +H DLAARNVL+ +DNV+KI DFGLAR +++ +
Sbjct: 583 PLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDY 642
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
Y+K N LPVKW+A E + DR+++ QSDVWS+GI+LWE+F+L +PYP I +L L
Sbjct: 643 YKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLL 702
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFL 960
+G+R+++PP LY +M CWH P+ RP+F +L E L L
Sbjct: 703 REGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL 747
Score = 93.5 bits (222), Expect = 4e-18
Identities = 53/135 (39%), Positives = 78/135 (57%), Gaps = 5/135 (3%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINA--EVTTPVAVKMVKRTADNMY 653
LP D +EFPR++L GK LG G FG V +AEA G+ A + + VAVKM+K A +
Sbjct: 454 LPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKD 513
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFI 713
+ L SE+++M +G+H NI+NLLG CT+ + L VIVE GN+ +++ R
Sbjct: 514 LADLVSEMEVMKLIGRHKNIINLLGVCTQ---EGPLYVIVECAAKGNLREFLRARRPPGP 570
Query: 714 DQLTDNAEKNLGKIN 728
D D + G ++
Sbjct: 571 DLSPDGPRSSEGPLS 585
Score = 38.3 bits (85), Expect = 0.16
Identities = 22/89 (24%), Positives = 39/89 (43%), Gaps = 4/89 (4%)
Query: 449 GRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNG 508
G +++ C A G P PTI W KD + + ++ + H + + +E++ D G
Sbjct: 165 GNTVKFRCPAAGNPTPTIRWLKDGQAFHGEN--RIGGIRLRHQ--HWSLVMESVVPSDRG 220
Query: 509 IYECVALNNASELRRAYTLVLKAEKSYTP 537
Y C+ N +R Y L + + P
Sbjct: 221 TYTCLVENAVGSIRYNYLLDVLERSPHRP 249
>X57205-1|CAA40490.1| 802|Homo sapiens fibroblast growth factor
receptor protein.
Length = 802
Score = 189 bits (460), Expect = 6e-47
Identities = 82/165 (49%), Positives = 117/165 (70%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
PL+ L+ A+Q+ARGM+YL +RK +H DLAARNVL+ +DNV+KI DFGLAR +++ +
Sbjct: 583 PLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDY 642
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
Y+K N LPVKW+A E + DR+++ QSDVWS+GI+LWE+F+L +PYP I +L L
Sbjct: 643 YKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLL 702
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFL 960
+G+R+++PP LY +M CWH P+ RP+F +L E L L
Sbjct: 703 REGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL 747
Score = 93.5 bits (222), Expect = 4e-18
Identities = 53/135 (39%), Positives = 78/135 (57%), Gaps = 5/135 (3%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINA--EVTTPVAVKMVKRTADNMY 653
LP D +EFPR++L GK LG G FG V +AEA G+ A + + VAVKM+K A +
Sbjct: 454 LPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKD 513
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFI 713
+ L SE+++M +G+H NI+NLLG CT+ + L VIVE GN+ +++ R
Sbjct: 514 LADLVSEMEVMKLIGRHKNIINLLGVCTQ---EGPLYVIVECAAKGNLREFLRARRPPGP 570
Query: 714 DQLTDNAEKNLGKIN 728
D D + G ++
Sbjct: 571 DLSPDGPRSSEGPLS 585
Score = 38.3 bits (85), Expect = 0.16
Identities = 22/89 (24%), Positives = 39/89 (43%), Gaps = 4/89 (4%)
Query: 449 GRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNG 508
G +++ C A G P PTI W KD + + ++ + H + + +E++ D G
Sbjct: 165 GNTVKFRCPAAGNPTPTIRWLKDGQAFHGEN--RIGGIRLRHQ--HWSLVMESVVPSDRG 220
Query: 509 IYECVALNNASELRRAYTLVLKAEKSYTP 537
Y C+ N +R Y L + + P
Sbjct: 221 TYTCLVENAVGSIRYNYLLDVLERSPHRP 249
>L03840-1|AAB59389.1| 802|Homo sapiens fibroblast growth factor
receptor 4 protein.
Length = 802
Score = 189 bits (460), Expect = 6e-47
Identities = 82/165 (49%), Positives = 117/165 (70%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
PL+ L+ A+Q+ARGM+YL +RK +H DLAARNVL+ +DNV+KI DFGLAR +++ +
Sbjct: 583 PLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDY 642
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
Y+K N LPVKW+A E + DR+++ QSDVWS+GI+LWE+F+L +PYP I +L L
Sbjct: 643 YKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLL 702
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFL 960
+G+R+++PP LY +M CWH P+ RP+F +L E L L
Sbjct: 703 REGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL 747
Score = 93.5 bits (222), Expect = 4e-18
Identities = 53/135 (39%), Positives = 78/135 (57%), Gaps = 5/135 (3%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINA--EVTTPVAVKMVKRTADNMY 653
LP D +EFPR++L GK LG G FG V +AEA G+ A + + VAVKM+K A +
Sbjct: 454 LPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKD 513
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFI 713
+ L SE+++M +G+H NI+NLLG CT+ + L VIVE GN+ +++ R
Sbjct: 514 LADLVSEMEVMKLIGRHKNIINLLGVCTQ---EGPLYVIVECAAKGNLREFLRARRPPGP 570
Query: 714 DQLTDNAEKNLGKIN 728
D D + G ++
Sbjct: 571 DLSPDGPRSSEGPLS 585
Score = 38.3 bits (85), Expect = 0.16
Identities = 22/89 (24%), Positives = 39/89 (43%), Gaps = 4/89 (4%)
Query: 449 GRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNG 508
G +++ C A G P PTI W KD + + ++ + H + + +E++ D G
Sbjct: 165 GNTVKFRCPAAGNPTPTIRWLKDGQAFHGEN--RIGGIRLRHQ--HWSLVMESVVPSDRG 220
Query: 509 IYECVALNNASELRRAYTLVLKAEKSYTP 537
Y C+ N +R Y L + + P
Sbjct: 221 TYTCLVENAVGSIRYNYLLDVLERSPHRP 249
>EF571596-1|ABQ01235.1| 802|Homo sapiens fibroblast growth factor
receptor 4 protein.
Length = 802
Score = 189 bits (460), Expect = 6e-47
Identities = 82/165 (49%), Positives = 117/165 (70%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
PL+ L+ A+Q+ARGM+YL +RK +H DLAARNVL+ +DNV+KI DFGLAR +++ +
Sbjct: 583 PLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDY 642
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
Y+K N LPVKW+A E + DR+++ QSDVWS+GI+LWE+F+L +PYP I +L L
Sbjct: 643 YKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLL 702
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFL 960
+G+R+++PP LY +M CWH P+ RP+F +L E L L
Sbjct: 703 REGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL 747
Score = 93.5 bits (222), Expect = 4e-18
Identities = 53/135 (39%), Positives = 78/135 (57%), Gaps = 5/135 (3%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINA--EVTTPVAVKMVKRTADNMY 653
LP D +EFPR++L GK LG G FG V +AEA G+ A + + VAVKM+K A +
Sbjct: 454 LPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKD 513
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFI 713
+ L SE+++M +G+H NI+NLLG CT+ + L VIVE GN+ +++ R
Sbjct: 514 LADLVSEMEVMKLIGRHKNIINLLGVCTQ---EGPLYVIVECAAKGNLREFLRARRPPGP 570
Query: 714 DQLTDNAEKNLGKIN 728
D D + G ++
Sbjct: 571 DLSPDGPRSSEGPLS 585
Score = 38.3 bits (85), Expect = 0.16
Identities = 22/89 (24%), Positives = 39/89 (43%), Gaps = 4/89 (4%)
Query: 449 GRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNG 508
G +++ C A G P PTI W KD + + ++ + H + + +E++ D G
Sbjct: 165 GNTVKFRCPAAGNPTPTIRWLKDGQAFHGEN--RIGGIRLRHQ--HWSLVMESVVPSDRG 220
Query: 509 IYECVALNNASELRRAYTLVLKAEKSYTP 537
Y C+ N +R Y L + + P
Sbjct: 221 TYTCLVENAVGSIRYNYLLDVLERSPHRP 249
>BC011847-1|AAH11847.1| 802|Homo sapiens fibroblast growth factor
receptor 4 protein.
Length = 802
Score = 189 bits (460), Expect = 6e-47
Identities = 82/165 (49%), Positives = 117/165 (70%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
PL+ L+ A+Q+ARGM+YL +RK +H DLAARNVL+ +DNV+KI DFGLAR +++ +
Sbjct: 583 PLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDY 642
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
Y+K N LPVKW+A E + DR+++ QSDVWS+GI+LWE+F+L +PYP I +L L
Sbjct: 643 YKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLL 702
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFL 960
+G+R+++PP LY +M CWH P+ RP+F +L E L L
Sbjct: 703 REGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL 747
Score = 93.5 bits (222), Expect = 4e-18
Identities = 53/135 (39%), Positives = 78/135 (57%), Gaps = 5/135 (3%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINA--EVTTPVAVKMVKRTADNMY 653
LP D +EFPR++L GK LG G FG V +AEA G+ A + + VAVKM+K A +
Sbjct: 454 LPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKD 513
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFI 713
+ L SE+++M +G+H NI+NLLG CT+ + L VIVE GN+ +++ R
Sbjct: 514 LADLVSEMEVMKLIGRHKNIINLLGVCTQ---EGPLYVIVECAAKGNLREFLRARRPPGP 570
Query: 714 DQLTDNAEKNLGKIN 728
D D + G ++
Sbjct: 571 DLSPDGPRSSEGPLS 585
Score = 38.3 bits (85), Expect = 0.16
Identities = 22/89 (24%), Positives = 39/89 (43%), Gaps = 4/89 (4%)
Query: 449 GRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNG 508
G +++ C A G P PTI W KD + + ++ + H + + +E++ D G
Sbjct: 165 GNTVKFRCPAAGNPTPTIRWLKDGQAFHGEN--RIGGIRLRHQ--HWSLVMESVVPSDRG 220
Query: 509 IYECVALNNASELRRAYTLVLKAEKSYTP 537
Y C+ N +R Y L + + P
Sbjct: 221 TYTCLVENAVGSIRYNYLLDVLERSPHRP 249
>AF487555-1|AAM13666.1| 802|Homo sapiens fibroblast growth factor
receptor 4 protein.
Length = 802
Score = 189 bits (460), Expect = 6e-47
Identities = 82/165 (49%), Positives = 117/165 (70%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
PL+ L+ A+Q+ARGM+YL +RK +H DLAARNVL+ +DNV+KI DFGLAR +++ +
Sbjct: 583 PLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDY 642
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
Y+K N LPVKW+A E + DR+++ QSDVWS+GI+LWE+F+L +PYP I +L L
Sbjct: 643 YKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLL 702
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFL 960
+G+R+++PP LY +M CWH P+ RP+F +L E L L
Sbjct: 703 REGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL 747
Score = 93.5 bits (222), Expect = 4e-18
Identities = 53/135 (39%), Positives = 78/135 (57%), Gaps = 5/135 (3%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINA--EVTTPVAVKMVKRTADNMY 653
LP D +EFPR++L GK LG G FG V +AEA G+ A + + VAVKM+K A +
Sbjct: 454 LPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKD 513
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFI 713
+ L SE+++M +G+H NI+NLLG CT+ + L VIVE GN+ +++ R
Sbjct: 514 LADLVSEMEVMKLIGRHKNIINLLGVCTQ---EGPLYVIVECAAKGNLREFLRARRPPGP 570
Query: 714 DQLTDNAEKNLGKIN 728
D D + G ++
Sbjct: 571 DLSPDGPRSSEGPLS 585
Score = 38.3 bits (85), Expect = 0.16
Identities = 22/89 (24%), Positives = 39/89 (43%), Gaps = 4/89 (4%)
Query: 449 GRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNG 508
G +++ C A G P PTI W KD + + ++ + H + + +E++ D G
Sbjct: 165 GNTVKFRCPAAGNPTPTIRWLKDGQAFHGEN--RIGGIRLRHQ--HWSLVMESVVPSDRG 220
Query: 509 IYECVALNNASELRRAYTLVLKAEKSYTP 537
Y C+ N +R Y L + + P
Sbjct: 221 TYTCLVENAVGSIRYNYLLDVLERSPHRP 249
>AF359246-1|AAK51435.1| 592|Homo sapiens fibroblast growth factor
receptor 4 variant protein.
Length = 592
Score = 189 bits (460), Expect = 6e-47
Identities = 82/165 (49%), Positives = 117/165 (70%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
PL+ L+ A+Q+ARGM+YL +RK +H DLAARNVL+ +DNV+KI DFGLAR +++ +
Sbjct: 373 PLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDY 432
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
Y+K N LPVKW+A E + DR+++ QSDVWS+GI+LWE+F+L +PYP I +L L
Sbjct: 433 YKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLL 492
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFL 960
+G+R+++PP LY +M CWH P+ RP+F +L E L L
Sbjct: 493 REGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL 537
Score = 93.5 bits (222), Expect = 4e-18
Identities = 53/135 (39%), Positives = 78/135 (57%), Gaps = 5/135 (3%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINA--EVTTPVAVKMVKRTADNMY 653
LP D +EFPR++L GK LG G FG V +AEA G+ A + + VAVKM+K A +
Sbjct: 244 LPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKD 303
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFI 713
+ L SE+++M +G+H NI+NLLG CT+ + L VIVE GN+ +++ R
Sbjct: 304 LADLVSEMEVMKLIGRHKNIINLLGVCTQ---EGPLYVIVECAAKGNLREFLRARRPPGP 360
Query: 714 DQLTDNAEKNLGKIN 728
D D + G ++
Sbjct: 361 DLSPDGPRSSEGPLS 375
>AF202063-1|AAF27432.1| 762|Homo sapiens fibroblast growth factor
receptor 4, soluble-form splice variant protein.
Length = 762
Score = 189 bits (460), Expect = 6e-47
Identities = 82/165 (49%), Positives = 117/165 (70%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
PL+ L+ A+Q+ARGM+YL +RK +H DLAARNVL+ +DNV+KI DFGLAR +++ +
Sbjct: 543 PLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDY 602
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
Y+K N LPVKW+A E + DR+++ QSDVWS+GI+LWE+F+L +PYP I +L L
Sbjct: 603 YKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLL 662
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFL 960
+G+R+++PP LY +M CWH P+ RP+F +L E L L
Sbjct: 663 REGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL 707
Score = 100 bits (239), Expect = 3e-20
Identities = 82/294 (27%), Positives = 137/294 (46%), Gaps = 20/294 (6%)
Query: 446 AMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKL----FVDIVNHTIVNSTFEIE- 500
A+ G ++L C+ +P I W K ++ N S + +V ++ +NS+ E+E
Sbjct: 261 AVVGSDVELLCKVYSDAQPHIQWLK--HIVINGSSFGADGFPYVQVLKTADINSS-EVEV 317
Query: 501 ----NMQEKDNGIYECVALNNASELRRAYTLVLKAEKSYTPYXXXXXXXXXXXXGMVAYL 556
N+ +D G Y C+A N+ ++ L + P+
Sbjct: 318 LYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPGTGRIPHLTCDSLTPAGRTKSPTLQ 377
Query: 557 FTWKLKKQRELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTFGKQLG 616
F+ + + + + L+ + S P L + LP D +EFPR++L GK LG
Sbjct: 378 FSLESGSSGK-SSSSLV--RGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLG 434
Query: 617 AGAFGVVYKAEARGIINA--EVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIV 674
G FG V +AEA G+ A + + VAVKM+K A + + L SE+++M +G+H NI+
Sbjct: 435 EGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNII 494
Query: 675 NLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDNAEKNLGKIN 728
NLLG CT+ + L VIVE GN+ +++ R D D + G ++
Sbjct: 495 NLLGVCTQ---EGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLS 545
Score = 40.3 bits (90), Expect = 0.039
Identities = 23/89 (25%), Positives = 40/89 (44%), Gaps = 4/89 (4%)
Query: 449 GRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNG 508
G +++ C A G P PTI W KD + + G ++ + H + + +E++ D G
Sbjct: 165 GNTVKFRCPAAGNPTPTIRWLKDGQAF--HGGNRIGGIRLRHQ--HWSLVMESVVPSDRG 220
Query: 509 IYECVALNNASELRRAYTLVLKAEKSYTP 537
Y C+ N +R Y L + + P
Sbjct: 221 TYTCLVENAVGSIRYNYLLDVLERSPHRP 249
>AB209631-1|BAD92868.1| 1034|Homo sapiens Fibroblast growth factor
receptor 4 variant protein.
Length = 1034
Score = 189 bits (460), Expect = 6e-47
Identities = 82/165 (49%), Positives = 117/165 (70%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
PL+ L+ A+Q+ARGM+YL +RK +H DLAARNVL+ +DNV+KI DFGLAR +++ +
Sbjct: 815 PLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDY 874
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
Y+K N LPVKW+A E + DR+++ QSDVWS+GI+LWE+F+L +PYP I +L L
Sbjct: 875 YKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLL 934
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFL 960
+G+R+++PP LY +M CWH P+ RP+F +L E L L
Sbjct: 935 REGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL 979
Score = 93.5 bits (222), Expect = 4e-18
Identities = 53/135 (39%), Positives = 78/135 (57%), Gaps = 5/135 (3%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINA--EVTTPVAVKMVKRTADNMY 653
LP D +EFPR++L GK LG G FG V +AEA G+ A + + VAVKM+K A +
Sbjct: 686 LPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKD 745
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFI 713
+ L SE+++M +G+H NI+NLLG CT+ + L VIVE GN+ +++ R
Sbjct: 746 LADLVSEMEVMKLIGRHKNIINLLGVCTQ---EGPLYVIVECAAKGNLREFLRARRPPGP 802
Query: 714 DQLTDNAEKNLGKIN 728
D D + G ++
Sbjct: 803 DLSPDGPRSSEGPLS 817
Score = 38.3 bits (85), Expect = 0.16
Identities = 22/89 (24%), Positives = 39/89 (43%), Gaps = 4/89 (4%)
Query: 449 GRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNG 508
G +++ C A G P PTI W KD + + ++ + H + + +E++ D G
Sbjct: 280 GNTVKFRCPAAGNPTPTIRWLKDGQAFHGEN--RIGGIRLRHQ--HWSLVMESVVPSDRG 335
Query: 509 IYECVALNNASELRRAYTLVLKAEKSYTP 537
Y C+ N +R Y L + + P
Sbjct: 336 TYTCLVENAVGSIRYNYLLDVLERSPHRP 364
>M80634-1|AAA36147.1| 822|Homo sapiens keratinocyte growth factor
receptor protein.
Length = 822
Score = 187 bits (455), Expect = 2e-46
Identities = 84/194 (43%), Positives = 128/194 (65%), Gaps = 2/194 (1%)
Query: 786 DYIYECHQ--PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y+ ++ +T L+ +Q+AR MEYLA++K +H DLAARNVL+ ++NV+KI D
Sbjct: 586 EYSYDINRVPEEQMTFKDLVSCTYQLARRMEYLASQKCIHRDLAARNVLVTENNVMKIAD 645
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR + N + Y+K N LPVKW+A E + DR+++ QSDVWS+G+++WE+F+L +PY
Sbjct: 646 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 705
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P I +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L L
Sbjct: 706 PGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLT 765
Query: 964 ERNRYVDLNAPYNE 977
Y+DL+ P +
Sbjct: 766 TNEEYLDLSQPLEQ 779
Score = 102 bits (244), Expect = 9e-21
Identities = 57/116 (49%), Positives = 71/116 (61%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGI--INAEVTTPVAVKMVKRTADNMY 653
LP D K+EFPR+KLT GK LG G FG V AEA GI + VAVKM+K A
Sbjct: 469 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 528
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y++ R
Sbjct: 529 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLRARR 581
Score = 37.1 bits (82), Expect = 0.37
Identities = 38/148 (25%), Positives = 65/148 (43%), Gaps = 14/148 (9%)
Query: 220 PVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYT 279
P+ +LKN K + + + N L + + +D NYT V EN+Y + N+T
Sbjct: 185 PMPTMRWLKNGKEF-KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHT 243
Query: 280 VDLRVFTK-PEAKLLNNRI---IKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSST 335
L V + P +L + + ++ F CKV P + WI + E + +
Sbjct: 244 YHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI----KHVEKNGS 299
Query: 336 KSEQESLYAKTDYLKISVQASGVITCNA 363
K + L YLK+ ++ SG+ + NA
Sbjct: 300 KYGPDGL----PYLKV-LKHSGINSSNA 322
Score = 33.9 bits (74), Expect = 3.4
Identities = 35/140 (25%), Positives = 55/140 (39%), Gaps = 22/140 (15%)
Query: 414 NVSWLGSDGNILDDIELLAPIIREPDSNK------DEEAMEGR--------SIQLHCEAE 459
NV+ S G+ DD + + E +NK + E ME R +++ C A
Sbjct: 123 NVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAG 182
Query: 460 GVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDNGIYECVALNN 517
G P PT+ W K N +K I + + N + + E++ D G Y CV N
Sbjct: 183 GNPMPTMRWLK------NGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE 236
Query: 518 ASELRRAYTLVLKAEKSYTP 537
+ Y L + + P
Sbjct: 237 YGSINHTYHLDVVERSPHRP 256
>X56348-1|CAA39792.1| 435|Homo sapiens urf-ret protein.
Length = 435
Score = 186 bits (454), Expect = 3e-46
Identities = 87/209 (41%), Positives = 129/209 (61%), Gaps = 5/209 (2%)
Query: 765 RSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHG 824
R RKV GY+ + R LT G L+ +A+QI++GM+YLA K++H
Sbjct: 180 RESRKVGPGYLGSGGSRNSSS---LDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHR 236
Query: 825 DLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSD 884
DLAARN+L+A+ +KI DFGL+R +Y + Y K+ +PVKW+AIE + D I++TQSD
Sbjct: 237 DLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSD 296
Query: 885 VWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPT 944
VWS+G++LWE+ +L PYP I P L L G+R+E+P + +Y +ML+CW Q+P
Sbjct: 297 VWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPD 356
Query: 945 ARPSFTELQEILGNFLEDNERNRYVDLNA 973
RP F ++ + L + +R Y+DL A
Sbjct: 357 KRPVFADISKDLEKMMV--KRRDYLDLAA 383
Score = 83.8 bits (198), Expect = 3e-15
Identities = 46/130 (35%), Positives = 72/130 (55%), Gaps = 4/130 (3%)
Query: 599 DEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALA 658
D K+EFPR+ L GK LG G FG V KA A + T VAVKM+K A ++ L
Sbjct: 77 DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLL 136
Query: 659 SELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTD 718
SE ++ + H +++ L GAC++ L++IVEY KYG++ ++++ R+V L
Sbjct: 137 SEFNVLKQV-NHPHVIKLYGACSQ---DGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGS 192
Query: 719 NAEKNLGKIN 728
+N ++
Sbjct: 193 GGSRNSSSLD 202
>X15786-1|CAA33787.1| 899|Homo sapiens retII protein.
Length = 899
Score = 186 bits (454), Expect = 3e-46
Identities = 87/209 (41%), Positives = 129/209 (61%), Gaps = 5/209 (2%)
Query: 765 RSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHG 824
R RKV GY+ + R LT G L+ +A+QI++GM+YLA K++H
Sbjct: 602 RESRKVGPGYLGSGGSRNSSS---LDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHR 658
Query: 825 DLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSD 884
DLAARN+L+A+ +KI DFGL+R +Y + Y K+ +PVKW+AIE + D I++TQSD
Sbjct: 659 DLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSD 718
Query: 885 VWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPT 944
VWS+G++LWE+ +L PYP I P L L G+R+E+P + +Y +ML+CW Q+P
Sbjct: 719 VWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPD 778
Query: 945 ARPSFTELQEILGNFLEDNERNRYVDLNA 973
RP F ++ + L + +R Y+DL A
Sbjct: 779 KRPVFADISKDLEKMMV--KRRDYLDLAA 805
Score = 84.2 bits (199), Expect = 2e-15
Identities = 47/133 (35%), Positives = 73/133 (54%), Gaps = 4/133 (3%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIK 655
L D K+EFPR+ L GK LG G FG V KA A + T VAVKM+K A ++
Sbjct: 496 LQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELR 555
Query: 656 ALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQ 715
L SE ++ + H +++ L GAC++ L++IVEY KYG++ ++++ R+V
Sbjct: 556 DLLSEFNVLKQV-NHPHVIKLYGACSQ---DGPLLLIVEYAKYGSLRGFLRESRKVGPGY 611
Query: 716 LTDNAEKNLGKIN 728
L +N ++
Sbjct: 612 LGSGGSRNSSSLD 624
>X12949-1|CAA31408.1| 860|Homo sapiens protein ( Human ret
proto-oncogene mRNA for tyrosine kinase. ).
Length = 860
Score = 186 bits (454), Expect = 3e-46
Identities = 87/209 (41%), Positives = 129/209 (61%), Gaps = 5/209 (2%)
Query: 765 RSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHG 824
R RKV GY+ + R LT G L+ +A+QI++GM+YLA K++H
Sbjct: 563 RESRKVGPGYLGSGGSRNSSS---LDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHR 619
Query: 825 DLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSD 884
DLAARN+L+A+ +KI DFGL+R +Y + Y K+ +PVKW+AIE + D I++TQSD
Sbjct: 620 DLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSD 679
Query: 885 VWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPT 944
VWS+G++LWE+ +L PYP I P L L G+R+E+P + +Y +ML+CW Q+P
Sbjct: 680 VWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPD 739
Query: 945 ARPSFTELQEILGNFLEDNERNRYVDLNA 973
RP F ++ + L + +R Y+DL A
Sbjct: 740 KRPVFADISKDLEKMMV--KRRDYLDLAA 766
Score = 83.8 bits (198), Expect = 3e-15
Identities = 46/130 (35%), Positives = 72/130 (55%), Gaps = 4/130 (3%)
Query: 599 DEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALA 658
D K+EFPR+ L GK LG G FG V KA A + T VAVKM+K A ++ L
Sbjct: 460 DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLL 519
Query: 659 SELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTD 718
SE ++ + H +++ L GAC++ L++IVEY KYG++ ++++ R+V L
Sbjct: 520 SEFNVLKQV-NHPHVIKLYGACSQ---DGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGS 575
Query: 719 NAEKNLGKIN 728
+N ++
Sbjct: 576 GGSRNSSSLD 585
>M31213-1|AAA36524.1| 503|Homo sapiens protein ( Human papillary
thyroid carcinoma-encoded protein mRNA, complete cds. ).
Length = 503
Score = 186 bits (454), Expect = 3e-46
Identities = 87/209 (41%), Positives = 129/209 (61%), Gaps = 5/209 (2%)
Query: 765 RSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHG 824
R RKV GY+ + R LT G L+ +A+QI++GM+YLA K++H
Sbjct: 206 RESRKVGPGYLGSGGSRNSSS---LDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHR 262
Query: 825 DLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSD 884
DLAARN+L+A+ +KI DFGL+R +Y + Y K+ +PVKW+AIE + D I++TQSD
Sbjct: 263 DLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSD 322
Query: 885 VWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPT 944
VWS+G++LWE+ +L PYP I P L L G+R+E+P + +Y +ML+CW Q+P
Sbjct: 323 VWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPD 382
Query: 945 ARPSFTELQEILGNFLEDNERNRYVDLNA 973
RP F ++ + L + +R Y+DL A
Sbjct: 383 KRPVFADISKDLEKMMV--KRRDYLDLAA 409
Score = 85.4 bits (202), Expect = 1e-15
Identities = 53/168 (31%), Positives = 88/168 (52%), Gaps = 5/168 (2%)
Query: 561 LKKQRELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAF 620
L+++ ++ K L +K K N + +A + D K+EFPR+ L GK LG G F
Sbjct: 66 LQQENKVLKIELETYKLKCKALQEENRDL-RKASVTIEDPKWEFPRKNLVLGKTLGEGEF 124
Query: 621 GVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHVNIVNLLGAC 680
G V KA A + T VAVKM+K A ++ L SE ++ + H +++ L GAC
Sbjct: 125 GKVVKATAFHLKGRGGYTTVAVKMLKENASPSELRDLLSEFNVLKQV-NHPHVIKLYGAC 183
Query: 681 TKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDNAEKNLGKIN 728
++ L++IVEY KYG++ ++++ R+V L +N ++
Sbjct: 184 SQ---DGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLD 228
>DQ104207-1|AAZ57203.1| 776|Homo sapiens HOOK3-RET fusion protein
protein.
Length = 776
Score = 186 bits (454), Expect = 3e-46
Identities = 87/209 (41%), Positives = 129/209 (61%), Gaps = 5/209 (2%)
Query: 765 RSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHG 824
R RKV GY+ + R LT G L+ +A+QI++GM+YLA K++H
Sbjct: 479 RESRKVGPGYLGSGGSRNSSS---LDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHR 535
Query: 825 DLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSD 884
DLAARN+L+A+ +KI DFGL+R +Y + Y K+ +PVKW+AIE + D I++TQSD
Sbjct: 536 DLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSD 595
Query: 885 VWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPT 944
VWS+G++LWE+ +L PYP I P L L G+R+E+P + +Y +ML+CW Q+P
Sbjct: 596 VWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPD 655
Query: 945 ARPSFTELQEILGNFLEDNERNRYVDLNA 973
RP F ++ + L + +R Y+DL A
Sbjct: 656 KRPVFADISKDLEKMMV--KRRDYLDLAA 682
Score = 83.8 bits (198), Expect = 3e-15
Identities = 46/130 (35%), Positives = 72/130 (55%), Gaps = 4/130 (3%)
Query: 599 DEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALA 658
D K+EFPR+ L GK LG G FG V KA A + T VAVKM+K A ++ L
Sbjct: 376 DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLL 435
Query: 659 SELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTD 718
SE ++ + H +++ L GAC++ L++IVEY KYG++ ++++ R+V L
Sbjct: 436 SEFNVLKQV-NHPHVIKLYGACSQ---DGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGS 491
Query: 719 NAEKNLGKIN 728
+N ++
Sbjct: 492 GGSRNSSSLD 501
>M16029-1|AAA36786.1| 805|Homo sapiens protein ( Human ret mRNA
encoding a tyrosine kinase, partial cds. ).
Length = 805
Score = 186 bits (453), Expect = 4e-46
Identities = 87/209 (41%), Positives = 129/209 (61%), Gaps = 5/209 (2%)
Query: 765 RSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHG 824
R RKV GY+ + R LT G L+ +A+QI++GM+YLA K++H
Sbjct: 550 RESRKVGPGYLGSGGSRNSSS---LDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHR 606
Query: 825 DLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSD 884
DLAARN+L+A+ +KI DFGL+R +Y + Y K+ +PVKW+AIE + D I++TQSD
Sbjct: 607 DLAARNILVAEGRKMKISDFGLSRDVYEEDPYVKRSQGRIPVKWMAIESLFDHIYTTQSD 666
Query: 885 VWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPT 944
VWS+G++LWE+ +L PYP I P L L G+R+E+P + +Y +ML+CW Q+P
Sbjct: 667 VWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPD 726
Query: 945 ARPSFTELQEILGNFLEDNERNRYVDLNA 973
RP F ++ + L + +R Y+DL A
Sbjct: 727 KRPVFADISKDLEKMMV--KRRDYLDLAA 753
Score = 83.8 bits (198), Expect = 3e-15
Identities = 46/130 (35%), Positives = 72/130 (55%), Gaps = 4/130 (3%)
Query: 599 DEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALA 658
D K+EFPR+ L GK LG G FG V KA A + T VAVKM+K A ++ L
Sbjct: 447 DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLL 506
Query: 659 SELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTD 718
SE ++ + H +++ L GAC++ L++IVEY KYG++ ++++ R+V L
Sbjct: 507 SEFNVLKQV-NHPHVIKLYGACSQ---DGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGS 562
Query: 719 NAEKNLGKIN 728
+N ++
Sbjct: 563 GGSRNSSSLD 572
>L03357-1|AAA60266.1| 593|Homo sapiens RET tyrosine kinase/cAMP
protein kinase A subunit RI protein.
Length = 593
Score = 186 bits (453), Expect = 4e-46
Identities = 87/209 (41%), Positives = 129/209 (61%), Gaps = 5/209 (2%)
Query: 765 RSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHG 824
R RKV GY+ + R LT G L+ +A+QI++GM+YLA K++H
Sbjct: 341 RESRKVGPGYLGSGGSRNSSS---LDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHR 397
Query: 825 DLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSD 884
DLAARN+L+A+ +KI DFGL+R +Y + Y K+ +PVKW+AIE + D I++TQSD
Sbjct: 398 DLAARNILVAEGRKMKISDFGLSRDVYEEDPYVKRSQGRIPVKWMAIESLFDHIYTTQSD 457
Query: 885 VWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPT 944
VWS+G++LWE+ +L PYP I P L L G+R+E+P + +Y +ML+CW Q+P
Sbjct: 458 VWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPD 517
Query: 945 ARPSFTELQEILGNFLEDNERNRYVDLNA 973
RP F ++ + L + +R Y+DL A
Sbjct: 518 KRPVFADISKDLEKMMV--KRRDYLDLAA 544
Score = 85.4 bits (202), Expect = 1e-15
Identities = 48/139 (34%), Positives = 75/139 (53%), Gaps = 4/139 (2%)
Query: 590 DEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTA 649
D +L D K+EFPR+ L GK LG G FG V KA A + T VAVKM+K A
Sbjct: 229 DSYRRILMEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENA 288
Query: 650 DNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
++ L SE ++ + H +++ L GAC++ L++IVEY KYG++ ++++ R
Sbjct: 289 SPSELRDLLSEFNVLKQV-NHPHVIKLYGACSQ---DGPLLLIVEYAKYGSLRGFLRESR 344
Query: 710 EVFIDQLTDNAEKNLGKIN 728
+V L +N ++
Sbjct: 345 KVGPGYLGSGGSRNSSSLD 363
>BC004257-1|AAH04257.1| 1072|Homo sapiens ret proto-oncogene protein.
Length = 1072
Score = 185 bits (451), Expect = 7e-46
Identities = 87/209 (41%), Positives = 129/209 (61%), Gaps = 5/209 (2%)
Query: 765 RSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHG 824
R RKV GY+ + R LT G L+ +A+QI++GM+YLA K++H
Sbjct: 817 RESRKVGPGYLGSGGSRNSSS---LDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHR 873
Query: 825 DLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSD 884
DLAARN+L+A+ +KI DFGL+R +Y + Y K+ +PVKW+AIE + D I++TQSD
Sbjct: 874 DLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSD 933
Query: 885 VWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPT 944
VWS+G++LWE+ +L PYP I P L L G+R+E+P + +Y +ML+CW Q+P
Sbjct: 934 VWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYCLMLQCWKQEPD 993
Query: 945 ARPSFTELQEILGNFLEDNERNRYVDLNA 973
RP F ++ + L + +R Y+DL A
Sbjct: 994 KRPVFADISKDLEKMMV--KRRDYLDLAA 1020
Score = 83.8 bits (198), Expect = 3e-15
Identities = 46/130 (35%), Positives = 72/130 (55%), Gaps = 4/130 (3%)
Query: 599 DEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALA 658
D K+EFPR+ L GK LG G FG V KA A + T VAVKM+K A ++ L
Sbjct: 714 DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLL 773
Query: 659 SELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTD 718
SE ++ + H +++ L GAC++ L++IVEY KYG++ ++++ R+V L
Sbjct: 774 SEFNVLKQV-NHPHVIKLYGACSQ---DGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGS 829
Query: 719 NAEKNLGKIN 728
+N ++
Sbjct: 830 GGSRNSSSLD 839
>AB030073-1|BAA89296.1| 819|Homo sapiens K-sam-IIH1 protein.
Length = 819
Score = 184 bits (447), Expect = 2e-45
Identities = 86/210 (40%), Positives = 131/210 (62%), Gaps = 2/210 (0%)
Query: 786 DYIYECHQ--PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y+ ++ +T L+ +Q+AR MEYLA++K +H DLAARNVL+ ++NV+KI D
Sbjct: 586 EYSYDINRVPEEQMTFKDLVSCTYQLARRMEYLASQKCIHRDLAARNVLVTENNVMKIAD 645
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR + N + Y+K N LPVKW+A E + DR+++ QSDVWS+G+++WE+F+L +PY
Sbjct: 646 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 705
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P I +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L L
Sbjct: 706 PGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLT 765
Query: 964 ERNRYVDLNAPYNEMNAELMTGEDYLAMVC 993
R + L N + G + A+ C
Sbjct: 766 TNERILTLTTNENFQSTSGREGTEIHALQC 795
Score = 102 bits (244), Expect = 9e-21
Identities = 57/116 (49%), Positives = 71/116 (61%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGI--INAEVTTPVAVKMVKRTADNMY 653
LP D K+EFPR+KLT GK LG G FG V AEA GI + VAVKM+K A
Sbjct: 469 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 528
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y++ R
Sbjct: 529 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLRARR 581
Score = 37.1 bits (82), Expect = 0.37
Identities = 38/148 (25%), Positives = 65/148 (43%), Gaps = 14/148 (9%)
Query: 220 PVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYT 279
P+ +LKN K + + + N L + + +D NYT V EN+Y + N+T
Sbjct: 185 PMPTMRWLKNGKEF-KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHT 243
Query: 280 VDLRVFTK-PEAKLLNNRI---IKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSST 335
L V + P +L + + ++ F CKV P + WI + E + +
Sbjct: 244 YHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI----KHVEKNGS 299
Query: 336 KSEQESLYAKTDYLKISVQASGVITCNA 363
K + L YLK+ ++ SG+ + NA
Sbjct: 300 KYGPDGL----PYLKV-LKHSGINSSNA 322
Score = 33.9 bits (74), Expect = 3.4
Identities = 35/140 (25%), Positives = 55/140 (39%), Gaps = 22/140 (15%)
Query: 414 NVSWLGSDGNILDDIELLAPIIREPDSNK------DEEAMEGR--------SIQLHCEAE 459
NV+ S G+ DD + + E +NK + E ME R +++ C A
Sbjct: 123 NVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAG 182
Query: 460 GVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDNGIYECVALNN 517
G P PT+ W K N +K I + + N + + E++ D G Y CV N
Sbjct: 183 GNPMPTMRWLK------NGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE 236
Query: 518 ASELRRAYTLVLKAEKSYTP 537
+ Y L + + P
Sbjct: 237 YGSINHTYHLDVVERSPHRP 256
>AB030077-1|BAA89300.1| 817|Homo sapiens K-sam-IIO2 protein.
Length = 817
Score = 182 bits (444), Expect = 5e-45
Identities = 84/191 (43%), Positives = 125/191 (65%), Gaps = 2/191 (1%)
Query: 786 DYIYECHQ--PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y+ ++ +T L+ +Q+AR MEYLA++K +H DLAARNVL+ ++NV+KI D
Sbjct: 586 EYSYDINRVPEEQMTFKDLVSCTYQLARRMEYLASQKCIHRDLAARNVLVTENNVMKIAD 645
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR + N + Y+K N LPVKW+A E + DR+++ QSDVWS+G+++WE+F+L +PY
Sbjct: 646 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 705
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
P I +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L L
Sbjct: 706 PGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLT 765
Query: 964 ERNRYVDLNAP 974
RY L P
Sbjct: 766 TNERYKLLPCP 776
Score = 102 bits (244), Expect = 9e-21
Identities = 57/116 (49%), Positives = 71/116 (61%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGI--INAEVTTPVAVKMVKRTADNMY 653
LP D K+EFPR+KLT GK LG G FG V AEA GI + VAVKM+K A
Sbjct: 469 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 528
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y++ R
Sbjct: 529 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLRARR 581
Score = 37.1 bits (82), Expect = 0.37
Identities = 38/148 (25%), Positives = 65/148 (43%), Gaps = 14/148 (9%)
Query: 220 PVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYT 279
P+ +LKN K + + + N L + + +D NYT V EN+Y + N+T
Sbjct: 185 PMPTMRWLKNGKEF-KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHT 243
Query: 280 VDLRVFTK-PEAKLLNNRI---IKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSST 335
L V + P +L + + ++ F CKV P + WI + E + +
Sbjct: 244 YHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI----KHVEKNGS 299
Query: 336 KSEQESLYAKTDYLKISVQASGVITCNA 363
K + L YLK+ ++ SG+ + NA
Sbjct: 300 KYGPDGL----PYLKV-LKHSGINSSNA 322
Score = 33.9 bits (74), Expect = 3.4
Identities = 35/140 (25%), Positives = 55/140 (39%), Gaps = 22/140 (15%)
Query: 414 NVSWLGSDGNILDDIELLAPIIREPDSNK------DEEAMEGR--------SIQLHCEAE 459
NV+ S G+ DD + + E +NK + E ME R +++ C A
Sbjct: 123 NVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAG 182
Query: 460 GVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDNGIYECVALNN 517
G P PT+ W K N +K I + + N + + E++ D G Y CV N
Sbjct: 183 GNPMPTMRWLK------NGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE 236
Query: 518 ASELRRAYTLVLKAEKSYTP 537
+ Y L + + P
Sbjct: 237 YGSINHTYHLDVVERSPHRP 256
>X56191-1|CAA39654.1| 769|Homo sapiens fibroblast growth factor
(FGR) receptor protein.
Length = 769
Score = 182 bits (443), Expect = 7e-45
Identities = 81/177 (45%), Positives = 122/177 (68%), Gaps = 2/177 (1%)
Query: 786 DYIYECHQ--PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y+ ++ +T L+ +Q+ARGMEYLA++K +H DLAARNVL+ ++NV+KI D
Sbjct: 586 EYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIAD 645
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR + N + Y+K N LPVKW+A E + DR+++ QSDVWS+G+++WE+F+L +PY
Sbjct: 646 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 705
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFL 960
P I +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L L
Sbjct: 706 PGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 762
Score = 102 bits (244), Expect = 9e-21
Identities = 57/116 (49%), Positives = 71/116 (61%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGI--INAEVTTPVAVKMVKRTADNMY 653
LP D K+EFPR+KLT GK LG G FG V AEA GI + VAVKM+K A
Sbjct: 469 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 528
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y++ R
Sbjct: 529 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLRARR 581
Score = 37.1 bits (82), Expect = 0.37
Identities = 38/148 (25%), Positives = 65/148 (43%), Gaps = 14/148 (9%)
Query: 220 PVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYT 279
P+ +LKN K + + + N L + + +D NYT V EN+Y + N+T
Sbjct: 185 PMPTMRWLKNGKEF-KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHT 243
Query: 280 VDLRVFTK-PEAKLLNNRI---IKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSST 335
L V + P +L + + ++ F CKV P + WI + E + +
Sbjct: 244 YHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI----KHVEKNGS 299
Query: 336 KSEQESLYAKTDYLKISVQASGVITCNA 363
K + L YLK+ ++ SG+ + NA
Sbjct: 300 KYGPDGL----PYLKV-LKHSGINSSNA 322
Score = 33.9 bits (74), Expect = 3.4
Identities = 35/140 (25%), Positives = 55/140 (39%), Gaps = 22/140 (15%)
Query: 414 NVSWLGSDGNILDDIELLAPIIREPDSNK------DEEAMEGR--------SIQLHCEAE 459
NV+ S G+ DD + + E +NK + E ME R +++ C A
Sbjct: 123 NVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAG 182
Query: 460 GVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDNGIYECVALNN 517
G P PT+ W K N +K I + + N + + E++ D G Y CV N
Sbjct: 183 GNPMPTMRWLK------NGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE 236
Query: 518 ASELRRAYTLVLKAEKSYTP 537
+ Y L + + P
Sbjct: 237 YGSINHTYHLDVVERSPHRP 256
>AJ243297-1|CAB46483.1| 1091|Homo sapiens RET tyrosine kinase
receptor protein.
Length = 1091
Score = 182 bits (443), Expect = 7e-45
Identities = 87/210 (41%), Positives = 129/210 (61%), Gaps = 6/210 (2%)
Query: 765 RSGRKVSEGYIQQEWQTKYEGDYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHG 824
R RKV GY+ + R LT G L+ +A+QI++GM+YLA K++H
Sbjct: 793 RESRKVGPGYLGSGGSRNSSS---LDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHR 849
Query: 825 DLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN-SPLPVKWLAIECMVDRIFSTQS 883
DLAARN+L+A+ +KI DFGL+R +Y + Y K+ +PVKW+AIE + D I++TQS
Sbjct: 850 DLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQVGRIPVKWMAIESLFDHIYTTQS 909
Query: 884 DVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKP 943
DVWS+G++LWE+ +L PYP I P L L G+R+E+P + +Y +ML+CW Q+P
Sbjct: 910 DVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEP 969
Query: 944 TARPSFTELQEILGNFLEDNERNRYVDLNA 973
RP F ++ + L + +R Y+DL A
Sbjct: 970 DKRPVFADISKDLEKMMV--KRRDYLDLAA 997
Score = 83.8 bits (198), Expect = 3e-15
Identities = 46/130 (35%), Positives = 72/130 (55%), Gaps = 4/130 (3%)
Query: 599 DEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALA 658
D K+EFPR+ L GK LG G FG V KA A + T VAVKM+K A ++ L
Sbjct: 690 DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLL 749
Query: 659 SELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTD 718
SE ++ + H +++ L GAC++ L++IVEY KYG++ ++++ R+V L
Sbjct: 750 SEFNVLKQV-NHPHVIKLYGACSQ---DGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGS 805
Query: 719 NAEKNLGKIN 728
+N ++
Sbjct: 806 GGSRNSSSLD 815
>AF360695-4|AAK94208.1| 766|Homo sapiens keratinocyte growth factor
receptor 2 isoform K-sam-IIC3 protein.
Length = 766
Score = 182 bits (443), Expect = 7e-45
Identities = 81/177 (45%), Positives = 122/177 (68%), Gaps = 2/177 (1%)
Query: 786 DYIYECHQ--PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y+ ++ +T L+ +Q+ARGMEYLA++K +H DLAARNVL+ ++NV+KI D
Sbjct: 583 EYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIAD 642
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR + N + Y+K N LPVKW+A E + DR+++ QSDVWS+G+++WE+F+L +PY
Sbjct: 643 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 702
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFL 960
P I +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L L
Sbjct: 703 PGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 759
Score = 102 bits (244), Expect = 9e-21
Identities = 57/116 (49%), Positives = 71/116 (61%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGI--INAEVTTPVAVKMVKRTADNMY 653
LP D K+EFPR+KLT GK LG G FG V AEA GI + VAVKM+K A
Sbjct: 466 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 525
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y++ R
Sbjct: 526 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLRARR 578
Score = 36.7 bits (81), Expect = 0.48
Identities = 38/145 (26%), Positives = 64/145 (44%), Gaps = 14/145 (9%)
Query: 220 PVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYT 279
P+ +LKN K + + + N L + + +D NYT V EN+Y + N+T
Sbjct: 185 PMPTMRWLKNGKEF-KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHT 243
Query: 280 VDLRVFTK-PEAKLLNNRI---IKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSST 335
L V + P +L + + ++ F CKV P + WI + E + +
Sbjct: 244 YHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI----KHVEKNGS 299
Query: 336 KSEQESLYAKTDYLKISVQASGVIT 360
K + L YLK+ ++A+GV T
Sbjct: 300 KYGPDGL----PYLKV-LKAAGVNT 319
Score = 33.9 bits (74), Expect = 3.4
Identities = 35/140 (25%), Positives = 55/140 (39%), Gaps = 22/140 (15%)
Query: 414 NVSWLGSDGNILDDIELLAPIIREPDSNK------DEEAMEGR--------SIQLHCEAE 459
NV+ S G+ DD + + E +NK + E ME R +++ C A
Sbjct: 123 NVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAG 182
Query: 460 GVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDNGIYECVALNN 517
G P PT+ W K N +K I + + N + + E++ D G Y CV N
Sbjct: 183 GNPMPTMRWLK------NGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE 236
Query: 518 ASELRRAYTLVLKAEKSYTP 537
+ Y L + + P
Sbjct: 237 YGSINHTYHLDVVERSPHRP 256
>AF097353-2|AAD31561.1| 554|Homo sapiens fibroblast growth factor
receptor 2 isoform IgIIIc isoform protein.
Length = 554
Score = 182 bits (443), Expect = 7e-45
Identities = 81/177 (45%), Positives = 122/177 (68%), Gaps = 2/177 (1%)
Query: 786 DYIYECHQ--PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y+ ++ +T L+ +Q+ARGMEYLA++K +H DLAARNVL+ ++NV+KI D
Sbjct: 372 EYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIAD 431
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR + N + Y+K N LPVKW+A E + DR+++ QSDVWS+G+++WE+F+L +PY
Sbjct: 432 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 491
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFL 960
P I +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L L
Sbjct: 492 PGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 548
Score = 102 bits (244), Expect = 9e-21
Identities = 57/116 (49%), Positives = 71/116 (61%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGI--INAEVTTPVAVKMVKRTADNMY 653
LP D K+EFPR+KLT GK LG G FG V AEA GI + VAVKM+K A
Sbjct: 255 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 314
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y++ R
Sbjct: 315 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLRARR 367
Score = 35.5 bits (78), Expect = 1.1
Identities = 31/105 (29%), Positives = 50/105 (47%), Gaps = 13/105 (12%)
Query: 260 TDIANYTLVAENKYLTKNYTVDLRVFTK-PEAKLLNNRI---IKRLENSEMNFACKVTGY 315
+D NYT V EN+Y + N+T L V + P +L + + ++ F CKV
Sbjct: 13 SDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSD 72
Query: 316 PLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYLKISVQASGVIT 360
P + WI + E + +K + L YLK+ ++A+GV T
Sbjct: 73 AQPHIQWI----KHVEKNGSKYGPDGL----PYLKV-LKAAGVNT 108
>AF097353-1|AAD31560.1| 555|Homo sapiens fibroblast growth receptor
2 IgIIIb isoform protein.
Length = 555
Score = 182 bits (443), Expect = 7e-45
Identities = 81/177 (45%), Positives = 122/177 (68%), Gaps = 2/177 (1%)
Query: 786 DYIYECHQ--PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y+ ++ +T L+ +Q+ARGMEYLA++K +H DLAARNVL+ ++NV+KI D
Sbjct: 373 EYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIAD 432
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR + N + Y+K N LPVKW+A E + DR+++ QSDVWS+G+++WE+F+L +PY
Sbjct: 433 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 492
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFL 960
P I +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L L
Sbjct: 493 PGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 549
Score = 102 bits (244), Expect = 9e-21
Identities = 57/116 (49%), Positives = 71/116 (61%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGI--INAEVTTPVAVKMVKRTADNMY 653
LP D K+EFPR+KLT GK LG G FG V AEA GI + VAVKM+K A
Sbjct: 256 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 315
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y++ R
Sbjct: 316 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLRARR 368
Score = 35.9 bits (79), Expect = 0.84
Identities = 31/108 (28%), Positives = 51/108 (47%), Gaps = 13/108 (12%)
Query: 260 TDIANYTLVAENKYLTKNYTVDLRVFTK-PEAKLLNNRI---IKRLENSEMNFACKVTGY 315
+D NYT V EN+Y + N+T L V + P +L + + ++ F CKV
Sbjct: 13 SDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSD 72
Query: 316 PLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYLKISVQASGVITCNA 363
P + WI + E + +K + L YLK+ ++ SG+ + NA
Sbjct: 73 AQPHIQWI----KHVEKNGSKYGPDGL----PYLKV-LKHSGINSSNA 111
>M35718-1|AAA36152.1| 682|Homo sapiens protein ( Human
heparin-binding growth factor receptor K-sam mRNA. ).
Length = 682
Score = 181 bits (440), Expect = 2e-44
Identities = 80/173 (46%), Positives = 121/173 (69%), Gaps = 2/173 (1%)
Query: 786 DYIYECHQ--PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y+ ++ +T L+ +Q+ARGMEYLA++K +H DLAARNVL+ ++NV+KI D
Sbjct: 495 EYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIAD 554
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR + N + Y+K N LPVKW+A E + DR+++ QSDVWS+G+++WE+F+L +PY
Sbjct: 555 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 614
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEIL 956
P I +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L
Sbjct: 615 PGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 667
Score = 102 bits (244), Expect = 9e-21
Identities = 57/116 (49%), Positives = 71/116 (61%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGI--INAEVTTPVAVKMVKRTADNMY 653
LP D K+EFPR+KLT GK LG G FG V AEA GI + VAVKM+K A
Sbjct: 378 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 437
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y++ R
Sbjct: 438 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLRARR 490
Score = 37.1 bits (82), Expect = 0.37
Identities = 38/148 (25%), Positives = 65/148 (43%), Gaps = 14/148 (9%)
Query: 220 PVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYT 279
P+ +LKN K + + + N L + + +D NYT V EN+Y + N+T
Sbjct: 96 PMPTMRWLKNGKEF-KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHT 154
Query: 280 VDLRVFTK-PEAKLLNNRI---IKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSST 335
L V + P +L + + ++ F CKV P + WI + E + +
Sbjct: 155 YHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI----KHVEKNGS 210
Query: 336 KSEQESLYAKTDYLKISVQASGVITCNA 363
K + L YLK+ ++ SG+ + NA
Sbjct: 211 KYGPDGL----PYLKV-LKHSGINSSNA 233
Score = 33.5 bits (73), Expect = 4.5
Identities = 22/89 (24%), Positives = 36/89 (40%), Gaps = 8/89 (8%)
Query: 451 SIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDNG 508
+++ C A G P PT+ W K N +K I + + N + + E++ D G
Sbjct: 85 TVKFRCPAGGNPMPTMRWLK------NGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKG 138
Query: 509 IYECVALNNASELRRAYTLVLKAEKSYTP 537
Y CV N + Y L + + P
Sbjct: 139 NYTCVVENEYGSINHTYHLDVVERSPHRP 167
>AB030078-1|BAA89301.1| 768|Homo sapiens K-sam-IIO3 protein.
Length = 768
Score = 179 bits (435), Expect = 6e-44
Identities = 80/177 (45%), Positives = 121/177 (68%), Gaps = 2/177 (1%)
Query: 786 DYIYECHQ--PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y+ ++ +T L+ +Q+AR MEYLA++K +H DLAARNVL+ ++NV+KI D
Sbjct: 586 EYSYDINRVPEEQMTFKDLVSCTYQLARRMEYLASQKCIHRDLAARNVLVTENNVMKIAD 645
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR + N + Y+K N LPVKW+A E + DR+++ QSDVWS+G+++WE+F+L +PY
Sbjct: 646 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 705
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFL 960
P I +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L L
Sbjct: 706 PGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 762
Score = 102 bits (244), Expect = 9e-21
Identities = 57/116 (49%), Positives = 71/116 (61%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGI--INAEVTTPVAVKMVKRTADNMY 653
LP D K+EFPR+KLT GK LG G FG V AEA GI + VAVKM+K A
Sbjct: 469 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 528
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y++ R
Sbjct: 529 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLRARR 581
Score = 37.1 bits (82), Expect = 0.37
Identities = 38/148 (25%), Positives = 65/148 (43%), Gaps = 14/148 (9%)
Query: 220 PVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYT 279
P+ +LKN K + + + N L + + +D NYT V EN+Y + N+T
Sbjct: 185 PMPTMRWLKNGKEF-KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHT 243
Query: 280 VDLRVFTK-PEAKLLNNRI---IKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSST 335
L V + P +L + + ++ F CKV P + WI + E + +
Sbjct: 244 YHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI----KHVEKNGS 299
Query: 336 KSEQESLYAKTDYLKISVQASGVITCNA 363
K + L YLK+ ++ SG+ + NA
Sbjct: 300 KYGPDGL----PYLKV-LKHSGINSSNA 322
Score = 33.9 bits (74), Expect = 3.4
Identities = 35/140 (25%), Positives = 55/140 (39%), Gaps = 22/140 (15%)
Query: 414 NVSWLGSDGNILDDIELLAPIIREPDSNK------DEEAMEGR--------SIQLHCEAE 459
NV+ S G+ DD + + E +NK + E ME R +++ C A
Sbjct: 123 NVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAG 182
Query: 460 GVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDNGIYECVALNN 517
G P PT+ W K N +K I + + N + + E++ D G Y CV N
Sbjct: 183 GNPMPTMRWLK------NGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE 236
Query: 518 ASELRRAYTLVLKAEKSYTP 537
+ Y L + + P
Sbjct: 237 YGSINHTYHLDVVERSPHRP 256
>AB030076-1|BAA89299.1| 771|Homo sapiens K-sam-IIO1 protein.
Length = 771
Score = 179 bits (435), Expect = 6e-44
Identities = 80/177 (45%), Positives = 121/177 (68%), Gaps = 2/177 (1%)
Query: 786 DYIYECHQ--PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y+ ++ +T L+ +Q+AR MEYLA++K +H DLAARNVL+ ++NV+KI D
Sbjct: 586 EYSYDINRVPEEQMTFKDLVSCTYQLARRMEYLASQKCIHRDLAARNVLVTENNVMKIAD 645
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR + N + Y+K N LPVKW+A E + DR+++ QSDVWS+G+++WE+F+L +PY
Sbjct: 646 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 705
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFL 960
P I +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L L
Sbjct: 706 PGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 762
Score = 102 bits (244), Expect = 9e-21
Identities = 57/116 (49%), Positives = 71/116 (61%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGI--INAEVTTPVAVKMVKRTADNMY 653
LP D K+EFPR+KLT GK LG G FG V AEA GI + VAVKM+K A
Sbjct: 469 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 528
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y++ R
Sbjct: 529 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLRARR 581
Score = 37.1 bits (82), Expect = 0.37
Identities = 38/148 (25%), Positives = 65/148 (43%), Gaps = 14/148 (9%)
Query: 220 PVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYT 279
P+ +LKN K + + + N L + + +D NYT V EN+Y + N+T
Sbjct: 185 PMPTMRWLKNGKEF-KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHT 243
Query: 280 VDLRVFTK-PEAKLLNNRI---IKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSST 335
L V + P +L + + ++ F CKV P + WI + E + +
Sbjct: 244 YHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI----KHVEKNGS 299
Query: 336 KSEQESLYAKTDYLKISVQASGVITCNA 363
K + L YLK+ ++ SG+ + NA
Sbjct: 300 KYGPDGL----PYLKV-LKHSGINSSNA 322
Score = 33.9 bits (74), Expect = 3.4
Identities = 35/140 (25%), Positives = 55/140 (39%), Gaps = 22/140 (15%)
Query: 414 NVSWLGSDGNILDDIELLAPIIREPDSNK------DEEAMEGR--------SIQLHCEAE 459
NV+ S G+ DD + + E +NK + E ME R +++ C A
Sbjct: 123 NVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAG 182
Query: 460 GVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDNGIYECVALNN 517
G P PT+ W K N +K I + + N + + E++ D G Y CV N
Sbjct: 183 GNPMPTMRWLK------NGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE 236
Query: 518 ASELRRAYTLVLKAEKSYTP 537
+ Y L + + P
Sbjct: 237 YGSINHTYHLDVVERSPHRP 256
>AB030075-1|BAA89298.1| 830|Homo sapiens K-sam-IIH3 protein.
Length = 830
Score = 179 bits (435), Expect = 6e-44
Identities = 80/177 (45%), Positives = 121/177 (68%), Gaps = 2/177 (1%)
Query: 786 DYIYECHQ--PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y+ ++ +T L+ +Q+AR MEYLA++K +H DLAARNVL+ ++NV+KI D
Sbjct: 586 EYSYDINRVPEEQMTFKDLVSCTYQLARRMEYLASQKCIHRDLAARNVLVTENNVMKIAD 645
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR + N + Y+K N LPVKW+A E + DR+++ QSDVWS+G+++WE+F+L +PY
Sbjct: 646 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 705
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFL 960
P I +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L L
Sbjct: 706 PGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 762
Score = 102 bits (244), Expect = 9e-21
Identities = 57/116 (49%), Positives = 71/116 (61%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGI--INAEVTTPVAVKMVKRTADNMY 653
LP D K+EFPR+KLT GK LG G FG V AEA GI + VAVKM+K A
Sbjct: 469 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 528
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y++ R
Sbjct: 529 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLRARR 581
Score = 37.1 bits (82), Expect = 0.37
Identities = 38/148 (25%), Positives = 65/148 (43%), Gaps = 14/148 (9%)
Query: 220 PVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYT 279
P+ +LKN K + + + N L + + +D NYT V EN+Y + N+T
Sbjct: 185 PMPTMRWLKNGKEF-KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHT 243
Query: 280 VDLRVFTK-PEAKLLNNRI---IKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSST 335
L V + P +L + + ++ F CKV P + WI + E + +
Sbjct: 244 YHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI----KHVEKNGS 299
Query: 336 KSEQESLYAKTDYLKISVQASGVITCNA 363
K + L YLK+ ++ SG+ + NA
Sbjct: 300 KYGPDGL----PYLKV-LKHSGINSSNA 322
Score = 33.9 bits (74), Expect = 3.4
Identities = 35/140 (25%), Positives = 55/140 (39%), Gaps = 22/140 (15%)
Query: 414 NVSWLGSDGNILDDIELLAPIIREPDSNK------DEEAMEGR--------SIQLHCEAE 459
NV+ S G+ DD + + E +NK + E ME R +++ C A
Sbjct: 123 NVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAG 182
Query: 460 GVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDNGIYECVALNN 517
G P PT+ W K N +K I + + N + + E++ D G Y CV N
Sbjct: 183 GNPMPTMRWLK------NGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE 236
Query: 518 ASELRRAYTLVLKAEKSYTP 537
+ Y L + + P
Sbjct: 237 YGSINHTYHLDVVERSPHRP 256
>AB030074-1|BAA89297.1| 819|Homo sapiens K-sam-IIH2 protein.
Length = 819
Score = 179 bits (435), Expect = 6e-44
Identities = 80/177 (45%), Positives = 121/177 (68%), Gaps = 2/177 (1%)
Query: 786 DYIYECHQ--PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
+Y Y+ ++ +T L+ +Q+AR MEYLA++K +H DLAARNVL+ ++NV+KI D
Sbjct: 586 EYSYDINRVPEEQMTFKDLVSCTYQLARRMEYLASQKCIHRDLAARNVLVTENNVMKIAD 645
Query: 844 FGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPY 903
FGLAR + N + Y+K N LPVKW+A E + DR+++ QSDVWS+G+++WE+F+L +PY
Sbjct: 646 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 705
Query: 904 PNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFL 960
P I +L + L +G+R++KP + LY +M CWH P+ RP+F +L E L L
Sbjct: 706 PGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 762
Score = 102 bits (244), Expect = 9e-21
Identities = 57/116 (49%), Positives = 71/116 (61%), Gaps = 5/116 (4%)
Query: 596 LPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGI--INAEVTTPVAVKMVKRTADNMY 653
LP D K+EFPR+KLT GK LG G FG V AEA GI + VAVKM+K A
Sbjct: 469 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 528
Query: 654 IKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ L SE+++M +GKH NI+NLLGACT+ L VIVEY GN+ Y++ R
Sbjct: 529 LSDLVSEMEMMKMIGKHKNIINLLGACTQ---DGPLYVIVEYASKGNLREYLRARR 581
Score = 37.1 bits (82), Expect = 0.37
Identities = 38/148 (25%), Positives = 65/148 (43%), Gaps = 14/148 (9%)
Query: 220 PVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVAENKYLTKNYT 279
P+ +LKN K + + + N L + + +D NYT V EN+Y + N+T
Sbjct: 185 PMPTMRWLKNGKEF-KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHT 243
Query: 280 VDLRVFTK-PEAKLLNNRI---IKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSST 335
L V + P +L + + ++ F CKV P + WI + E + +
Sbjct: 244 YHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI----KHVEKNGS 299
Query: 336 KSEQESLYAKTDYLKISVQASGVITCNA 363
K + L YLK+ ++ SG+ + NA
Sbjct: 300 KYGPDGL----PYLKV-LKHSGINSSNA 322
Score = 33.9 bits (74), Expect = 3.4
Identities = 35/140 (25%), Positives = 55/140 (39%), Gaps = 22/140 (15%)
Query: 414 NVSWLGSDGNILDDIELLAPIIREPDSNK------DEEAMEGR--------SIQLHCEAE 459
NV+ S G+ DD + + E +NK + E ME R +++ C A
Sbjct: 123 NVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAG 182
Query: 460 GVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEI--ENMQEKDNGIYECVALNN 517
G P PT+ W K N +K I + + N + + E++ D G Y CV N
Sbjct: 183 GNPMPTMRWLK------NGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE 236
Query: 518 ASELRRAYTLVLKAEKSYTP 537
+ Y L + + P
Sbjct: 237 YGSINHTYHLDVVERSPHRP 256
>X54559-1|CAB56793.1| 1390|Homo sapiens proto-oncogene protein.
Length = 1390
Score = 177 bits (432), Expect = 1e-43
Identities = 84/188 (44%), Positives = 118/188 (62%), Gaps = 5/188 (2%)
Query: 790 ECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARS 849
E H P T L+G+ Q+A+GM+YLA++K +H DLAARN +L + VK+ DFGLAR
Sbjct: 1172 ETHNP---TVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARD 1228
Query: 850 MYNNEEYQ--KKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS 907
MY+ E Y K + LPVKW+A+E + + F+T+SDVWS+G+VLWE+ + PYP+++
Sbjct: 1229 MYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVVLWELMTRGAPPYPDVN 1288
Query: 908 PTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNR 967
D+ +L G RL +P + D LY VML+CWH K RPSF+EL +
Sbjct: 1289 TFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEH 1348
Query: 968 YVDLNAPY 975
YV +NA Y
Sbjct: 1349 YVHVNATY 1356
>U19348-1|AAA92686.1| 523|Homo sapiens tpr-met fusion protein
protein.
Length = 523
Score = 176 bits (429), Expect = 3e-43
Identities = 83/188 (44%), Positives = 118/188 (62%), Gaps = 5/188 (2%)
Query: 790 ECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARS 849
E H P T L+G+ Q+A+GM+YLA++K +H DLAARN +L + VK+ DFGLAR
Sbjct: 305 ETHNP---TVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARD 361
Query: 850 MYNNEEYQ--KKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS 907
MY+ E Y K + LPVKW+A+E + + F+T+SDVWS+G++LWE+ + PYP+++
Sbjct: 362 MYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVN 421
Query: 908 PTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNR 967
D+ +L G RL +P + D LY VML+CWH K RPSF+EL +
Sbjct: 422 TFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEH 481
Query: 968 YVDLNAPY 975
YV +NA Y
Sbjct: 482 YVHVNATY 489
>U08818-1|AAB60323.1| 455|Homo sapiens activated met oncogene
protein.
Length = 455
Score = 176 bits (429), Expect = 3e-43
Identities = 83/188 (44%), Positives = 118/188 (62%), Gaps = 5/188 (2%)
Query: 790 ECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARS 849
E H P T L+G+ Q+A+GM+YLA++K +H DLAARN +L + VK+ DFGLAR
Sbjct: 237 ETHNP---TVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARD 293
Query: 850 MYNNEEYQ--KKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS 907
MY+ E Y K + LPVKW+A+E + + F+T+SDVWS+G++LWE+ + PYP+++
Sbjct: 294 MYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVN 353
Query: 908 PTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNR 967
D+ +L G RL +P + D LY VML+CWH K RPSF+EL +
Sbjct: 354 TFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEH 413
Query: 968 YVDLNAPY 975
YV +NA Y
Sbjct: 414 YVHVNATY 421
>BC130420-1|AAI30421.1| 1390|Homo sapiens met proto-oncogene
(hepatocyte growth factor receptor) protein.
Length = 1390
Score = 176 bits (429), Expect = 3e-43
Identities = 83/188 (44%), Positives = 118/188 (62%), Gaps = 5/188 (2%)
Query: 790 ECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARS 849
E H P T L+G+ Q+A+GM+YLA++K +H DLAARN +L + VK+ DFGLAR
Sbjct: 1172 ETHNP---TVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARD 1228
Query: 850 MYNNEEYQ--KKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS 907
MY+ E Y K + LPVKW+A+E + + F+T+SDVWS+G++LWE+ + PYP+++
Sbjct: 1229 MYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVN 1288
Query: 908 PTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNR 967
D+ +L G RL +P + D LY VML+CWH K RPSF+EL +
Sbjct: 1289 TFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEH 1348
Query: 968 YVDLNAPY 975
YV +NA Y
Sbjct: 1349 YVHVNATY 1356
>AB209898-1|BAD93135.1| 712|Homo sapiens met proto-oncogene
precursor variant protein.
Length = 712
Score = 176 bits (429), Expect = 3e-43
Identities = 83/188 (44%), Positives = 118/188 (62%), Gaps = 5/188 (2%)
Query: 790 ECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARS 849
E H P T L+G+ Q+A+GM+YLA++K +H DLAARN +L + VK+ DFGLAR
Sbjct: 494 ETHNP---TVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARD 550
Query: 850 MYNNEEYQ--KKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS 907
MY+ E Y K + LPVKW+A+E + + F+T+SDVWS+G++LWE+ + PYP+++
Sbjct: 551 MYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVN 610
Query: 908 PTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNR 967
D+ +L G RL +P + D LY VML+CWH K RPSF+EL +
Sbjct: 611 TFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEH 670
Query: 968 YVDLNAPY 975
YV +NA Y
Sbjct: 671 YVHVNATY 678
>J02958-1|AAA59591.1| 1408|Homo sapiens MET protein.
Length = 1408
Score = 175 bits (426), Expect = 8e-43
Identities = 83/188 (44%), Positives = 117/188 (62%), Gaps = 5/188 (2%)
Query: 790 ECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARS 849
E H P T L+G+ Q+A+ M+YLA++K +H DLAARN +L + VK+ DFGLAR
Sbjct: 1190 ETHNP---TVKDLIGFGLQVAKAMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARD 1246
Query: 850 MYNNEEYQ--KKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS 907
MY+ E Y K + LPVKW+A+E + + F+T+SDVWS+G+VLWE+ + PYP+++
Sbjct: 1247 MYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVVLWELMTRGAPPYPDVN 1306
Query: 908 PTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNR 967
D+ +L G RL +P + D LY VML+CWH K RPSF+EL +
Sbjct: 1307 TFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEH 1366
Query: 968 YVDLNAPY 975
YV +NA Y
Sbjct: 1367 YVHVNATY 1374
>BC035514-1|AAH35514.2| 1124|Homo sapiens TEK tyrosine kinase,
endothelial (venous malformations, multiple cutaneous and
protein.
Length = 1124
Score = 169 bits (411), Expect = 5e-41
Identities = 82/174 (47%), Positives = 115/174 (66%), Gaps = 5/174 (2%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
L+S HLL +A +ARGM+YL+ ++ +H DLAARN+L+ ++ V KI DFGL+R E Y
Sbjct: 936 LSSHHLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ---EVY 992
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
KK LPV+W+AIE + +++T SDVWSYG++LWE+ SL TPY ++ +L L
Sbjct: 993 VKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLP 1052
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVD 970
G RLEKP DD +Y++M +CW +KP RPSF ++ L LE ER YV+
Sbjct: 1053 QGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLE--ERKTYVN 1104
Score = 57.6 bits (133), Expect = 2e-07
Identities = 35/106 (33%), Positives = 57/106 (53%), Gaps = 6/106 (5%)
Query: 609 LTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLG 668
+ F +G G FG V KA + + A+K +K A + A EL+++ LG
Sbjct: 824 IKFQDVIGEGNFGQVLKARIK---KDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLG 880
Query: 669 KHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFID 714
H NI+NLLGAC +H + L + +EY +GN+ ++++K R + D
Sbjct: 881 HHPNIINLLGAC-EH--RGYLYLAIEYAPHGNLLDFLRKSRVLETD 923
>X57019-1|CAA40338.1| 894|Homo sapiens protein ( H.sapiens mRNA for
tyrosine kinase receptor. ).
Length = 894
Score = 166 bits (404), Expect = 4e-40
Identities = 73/169 (43%), Positives = 115/169 (68%)
Query: 793 QPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYN 852
QP L + L+ + IA GMEYL+ ++ +H DLAARN +L ++ V + DFGL++ +YN
Sbjct: 640 QPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYN 699
Query: 853 NEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLL 912
+ Y++ + +PVKW+AIE + DR+++++SDVWS+G+ +WE+ + +TPYP + +++
Sbjct: 700 GDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIY 759
Query: 913 RWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
+L GNRL++P D LY +M RCW P RPSFTEL+E L N L+
Sbjct: 760 DYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLK 808
Score = 42.3 bits (95), Expect = 0.010
Identities = 33/124 (26%), Positives = 58/124 (46%), Gaps = 10/124 (8%)
Query: 586 NLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMV 645
+LGI E+ D + R K+ GK LG G FG V + + + + VAVK +
Sbjct: 515 SLGISEELKEKLRDVMVD--RHKVALGKTLGEGEFGAVMEGQ---LNQDDSILKVAVKTM 569
Query: 646 K-RTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKREL---IVIVEYCKYGNI 701
K ++ SE M H N++ L+G C + + +VI+ + K+G++
Sbjct: 570 KIAICTRSELEDFLSEAVCMKEF-DHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDL 628
Query: 702 HNYM 705
H+++
Sbjct: 629 HSFL 632
Score = 33.1 bits (72), Expect = 5.9
Identities = 20/86 (23%), Positives = 41/86 (47%), Gaps = 6/86 (6%)
Query: 432 APIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELI----SNNSGYKLFVDI 487
+P + P + + G +++ + +G P P ++W +D +++ S + L D
Sbjct: 35 SPFVGNPGNITGARGLTG-TLRCQLQVQGEP-PEVHWLRDGQILELADSTQTQVPLGEDE 92
Query: 488 VNHTIVNSTFEIENMQEKDNGIYECV 513
+ IV S I ++Q D G Y+C+
Sbjct: 93 QDDWIVVSQLRITSLQLSDTGQYQCL 118
>S65125-1|AAB20305.1| 894|Homo sapiens UFO protein.
Length = 894
Score = 166 bits (404), Expect = 4e-40
Identities = 73/169 (43%), Positives = 115/169 (68%)
Query: 793 QPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYN 852
QP L + L+ + IA GMEYL+ ++ +H DLAARN +L ++ V + DFGL++ +YN
Sbjct: 640 QPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYN 699
Query: 853 NEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLL 912
+ Y++ + +PVKW+AIE + DR+++++SDVWS+G+ +WE+ + +TPYP + +++
Sbjct: 700 GDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIY 759
Query: 913 RWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
+L GNRL++P D LY +M RCW P RPSFTEL+E L N L+
Sbjct: 760 DYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLK 808
Score = 42.3 bits (95), Expect = 0.010
Identities = 33/124 (26%), Positives = 58/124 (46%), Gaps = 10/124 (8%)
Query: 586 NLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMV 645
+LGI E+ D + R K+ GK LG G FG V + + + + VAVK +
Sbjct: 515 SLGISEELKEKLRDVMVD--RHKVALGKTLGEGEFGAVMEGQ---LNQDDSILKVAVKTM 569
Query: 646 K-RTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKREL---IVIVEYCKYGNI 701
K ++ SE M H N++ L+G C + + +VI+ + K+G++
Sbjct: 570 KIAICTRSELEDFLSEAVCMKEF-DHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDL 628
Query: 702 HNYM 705
H+++
Sbjct: 629 HSFL 632
Score = 33.1 bits (72), Expect = 5.9
Identities = 20/86 (23%), Positives = 41/86 (47%), Gaps = 6/86 (6%)
Query: 432 APIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELI----SNNSGYKLFVDI 487
+P + P + + G +++ + +G P P ++W +D +++ S + L D
Sbjct: 35 SPFVGNPGNITGARGLTG-TLRCQLQVQGEP-PEVHWLRDGQILELADSTQTQVPLGEDE 92
Query: 488 VNHTIVNSTFEIENMQEKDNGIYECV 513
+ IV S I ++Q D G Y+C+
Sbjct: 93 QDDWIVVSQLRITSLQLSDTGQYQCL 118
>M76125-1|AAA61243.1| 885|Homo sapiens tyrosine kinase receptor
protein.
Length = 885
Score = 166 bits (404), Expect = 4e-40
Identities = 73/169 (43%), Positives = 115/169 (68%)
Query: 793 QPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYN 852
QP L + L+ + IA GMEYL+ ++ +H DLAARN +L ++ V + DFGL++ +YN
Sbjct: 631 QPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYN 690
Query: 853 NEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLL 912
+ Y++ + +PVKW+AIE + DR+++++SDVWS+G+ +WE+ + +TPYP + +++
Sbjct: 691 GDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIY 750
Query: 913 RWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
+L GNRL++P D LY +M RCW P RPSFTEL+E L N L+
Sbjct: 751 DYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLK 799
Score = 42.3 bits (95), Expect = 0.010
Identities = 33/124 (26%), Positives = 58/124 (46%), Gaps = 10/124 (8%)
Query: 586 NLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMV 645
+LGI E+ D + R K+ GK LG G FG V + + + + VAVK +
Sbjct: 506 SLGISEELKEKLRDVMVD--RHKVALGKTLGEGEFGAVMEGQ---LNQDDSILKVAVKTM 560
Query: 646 K-RTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKREL---IVIVEYCKYGNI 701
K ++ SE M H N++ L+G C + + +VI+ + K+G++
Sbjct: 561 KIAICTRSELEDFLSEAVCMKEF-DHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDL 619
Query: 702 HNYM 705
H+++
Sbjct: 620 HSFL 623
Score = 33.1 bits (72), Expect = 5.9
Identities = 20/86 (23%), Positives = 41/86 (47%), Gaps = 6/86 (6%)
Query: 432 APIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELI----SNNSGYKLFVDI 487
+P + P + + G +++ + +G P P ++W +D +++ S + L D
Sbjct: 35 SPFVGNPGNITGARGLTG-TLRCQLQVQGEP-PEVHWLRDGQILELADSTQTQVPLGEDE 92
Query: 488 VNHTIVNSTFEIENMQEKDNGIYECV 513
+ IV S I ++Q D G Y+C+
Sbjct: 93 QDDWIVVSQLRITSLQLSDTGQYQCL 118
>L06139-1|AAA61139.1| 1124|Homo sapiens receptor protein-tyrosine
kinase protein.
Length = 1124
Score = 166 bits (403), Expect = 5e-40
Identities = 81/174 (46%), Positives = 114/174 (65%), Gaps = 5/174 (2%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
L+S LL +A +ARGM+YL+ ++ +H DLAARN+L+ ++ V KI DFGL+R E Y
Sbjct: 936 LSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ---EVY 992
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
KK LPV+W+AIE + +++T SDVWSYG++LWE+ SL TPY ++ +L L
Sbjct: 993 VKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLP 1052
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVD 970
G RLEKP DD +Y++M +CW +KP RPSF ++ L LE ER YV+
Sbjct: 1053 QGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLE--ERKTYVN 1104
Score = 57.6 bits (133), Expect = 2e-07
Identities = 35/106 (33%), Positives = 57/106 (53%), Gaps = 6/106 (5%)
Query: 609 LTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLG 668
+ F +G G FG V KA + + A+K +K A + A EL+++ LG
Sbjct: 824 IKFQDVIGEGNFGQVLKARIK---KDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLG 880
Query: 669 KHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFID 714
H NI+NLLGAC +H + L + +EY +GN+ ++++K R + D
Sbjct: 881 HHPNIINLLGAC-EH--RGYLYLAIEYAPHGNLLDFLRKSRVLETD 923
>AL133411-1|CAI16055.1| 1124|Homo sapiens TEK tyrosine kinase,
endothelial (venous malformations, multiple cutaneous and
protein.
Length = 1124
Score = 166 bits (403), Expect = 5e-40
Identities = 81/174 (46%), Positives = 114/174 (65%), Gaps = 5/174 (2%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
L+S LL +A +ARGM+YL+ ++ +H DLAARN+L+ ++ V KI DFGL+R E Y
Sbjct: 936 LSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ---EVY 992
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
KK LPV+W+AIE + +++T SDVWSYG++LWE+ SL TPY ++ +L L
Sbjct: 993 VKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLP 1052
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVD 970
G RLEKP DD +Y++M +CW +KP RPSF ++ L LE ER YV+
Sbjct: 1053 QGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLE--ERKTYVN 1104
Score = 57.6 bits (133), Expect = 2e-07
Identities = 35/106 (33%), Positives = 57/106 (53%), Gaps = 6/106 (5%)
Query: 609 LTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLG 668
+ F +G G FG V KA + + A+K +K A + A EL+++ LG
Sbjct: 824 IKFQDVIGEGNFGQVLKARIK---KDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLG 880
Query: 669 KHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFID 714
H NI+NLLGAC +H + L + +EY +GN+ ++++K R + D
Sbjct: 881 HHPNIINLLGAC-EH--RGYLYLAIEYAPHGNLLDFLRKSRVLETD 923
>AB208796-1|BAD92033.1| 1157|Homo sapiens TEK tyrosine kinase variant
protein.
Length = 1157
Score = 166 bits (403), Expect = 5e-40
Identities = 81/174 (46%), Positives = 114/174 (65%), Gaps = 5/174 (2%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
L+S LL +A +ARGM+YL+ ++ +H DLAARN+L+ ++ V KI DFGL+R E Y
Sbjct: 969 LSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ---EVY 1025
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
KK LPV+W+AIE + +++T SDVWSYG++LWE+ SL TPY ++ +L L
Sbjct: 1026 VKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLP 1085
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVD 970
G RLEKP DD +Y++M +CW +KP RPSF ++ L LE ER YV+
Sbjct: 1086 QGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLE--ERKTYVN 1137
Score = 57.6 bits (133), Expect = 2e-07
Identities = 35/106 (33%), Positives = 57/106 (53%), Gaps = 6/106 (5%)
Query: 609 LTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLG 668
+ F +G G FG V KA + + A+K +K A + A EL+++ LG
Sbjct: 857 IKFQDVIGEGNFGQVLKARIK---KDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLG 913
Query: 669 KHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFID 714
H NI+NLLGAC +H + L + +EY +GN+ ++++K R + D
Sbjct: 914 HHPNIINLLGAC-EH--RGYLYLAIEYAPHGNLLDFLRKSRVLETD 956
>BC032229-1|AAH32229.1| 894|Homo sapiens AXL receptor tyrosine
kinase protein.
Length = 894
Score = 165 bits (402), Expect = 6e-40
Identities = 73/169 (43%), Positives = 115/169 (68%)
Query: 793 QPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYN 852
QP L + L+ + IA GMEYL+ ++ +H DLAARN +L ++ V + DFGL++ +YN
Sbjct: 640 QPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYN 699
Query: 853 NEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLL 912
+ Y++ + +PVKW+AIE + DR+++++SDVWS+G+ +WE+ + +TPYP + +++
Sbjct: 700 GDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIY 759
Query: 913 RWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
+L GNRL++P D LY +M RCW P RPSFTEL+E L N L+
Sbjct: 760 DYLRRGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLK 808
Score = 42.3 bits (95), Expect = 0.010
Identities = 33/124 (26%), Positives = 58/124 (46%), Gaps = 10/124 (8%)
Query: 586 NLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMV 645
+LGI E+ D + R K+ GK LG G FG V + + + + VAVK +
Sbjct: 515 SLGISEELKEKLRDVMVD--RHKVALGKTLGEGEFGAVMEGQ---LNQDDSILKVAVKTM 569
Query: 646 K-RTADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKREL---IVIVEYCKYGNI 701
K ++ SE M H N++ L+G C + + +VI+ + K+G++
Sbjct: 570 KIAICTRSELEDFLSEAVCMKEF-DHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDL 628
Query: 702 HNYM 705
H+++
Sbjct: 629 HSFL 632
Score = 33.1 bits (72), Expect = 5.9
Identities = 20/86 (23%), Positives = 41/86 (47%), Gaps = 6/86 (6%)
Query: 432 APIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELI----SNNSGYKLFVDI 487
+P + P + + G +++ + +G P P ++W +D +++ S + L D
Sbjct: 35 SPFVGNPGNITGARGLTG-TLRCQLQVQGEP-PEVHWLRDGQILELADSTQTQVPLGEDE 92
Query: 488 VNHTIVNSTFEIENMQEKDNGIYECV 513
+ IV S I ++Q D G Y+C+
Sbjct: 93 QDDWIVVSQLRITSLQLSDTGQYQCL 118
>X70040-1|CAA49634.1| 1400|Homo sapiens tyrosine kinase protein.
Length = 1400
Score = 163 bits (397), Expect = 2e-39
Identities = 84/198 (42%), Positives = 120/198 (60%), Gaps = 11/198 (5%)
Query: 785 GDYIYECHQP-RPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICD 843
GD + P R T L+ + Q+ARGMEYLA +K +H DLAARN +L + VK+ D
Sbjct: 1167 GDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVAD 1226
Query: 844 FGLARSMYNNEEY--QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKT 901
FGLAR + + E Y Q+ ++ LPVKW+A+E + F+T+SDVWS+G++LWE+ +
Sbjct: 1227 FGLARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAP 1286
Query: 902 PYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFT----ELQEILG 957
PY +I P DL +L+ G RL +P + D LY VM +CW P RP+F E+++I+
Sbjct: 1287 PYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVS 1346
Query: 958 NFLEDNERNRYVDLNAPY 975
L D+ YV L A Y
Sbjct: 1347 ALLGDH----YVQLPATY 1360
>X72886-1|CAA51396.1| 272|Homo sapiens TYRO3 protein.
Length = 272
Score = 160 bits (388), Expect = 3e-38
Identities = 70/159 (44%), Positives = 107/159 (67%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ + IA GMEYL++R +H DLAARN +LA+D V + DFGL+R +Y+ + Y++
Sbjct: 114 LIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCA 173
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
S LPVKWLA+E + D +++ QSDVW++G+ +WE+ + +TPY I ++ +L GNRL
Sbjct: 174 SKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRL 233
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFL 960
++PP + +Y++M +CW P RPSFT L+ L N L
Sbjct: 234 KQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENIL 272
Score = 37.5 bits (83), Expect = 0.28
Identities = 31/104 (29%), Positives = 51/104 (49%), Gaps = 7/104 (6%)
Query: 610 TFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKR-TADNMYIKALASELKIMVHLG 668
T G+ LG G FG V +A+ + + V VAVKM+K + I+ E M
Sbjct: 1 TLGRMLGKGEFGSVREAQLKQEDGSFV--KVAVKMLKADIIASSDIEEFLREAACMKEF- 57
Query: 669 KHVNIVNLLGACTKHIAKREL---IVIVEYCKYGNIHNYMQKHR 709
H ++ L+G + AK L +VI+ + K+G++H ++ R
Sbjct: 58 DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASR 101
>U18934-1|AAC50070.1| 882|Homo sapiens receptor tyrosine kinase
protein.
Length = 882
Score = 160 bits (388), Expect = 3e-38
Identities = 71/160 (44%), Positives = 108/160 (67%), Gaps = 4/160 (2%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ + IA GMEYL++R +H DLAARN +LA+D V + DFGL+R +Y+ + Y++
Sbjct: 624 LIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCA 683
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
S LPVKWLA+E + D +++ QSDVW++G+ +WE+ + +TPY I ++ +L GNRL
Sbjct: 684 SKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRL 743
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFT----ELQEILG 957
++PP + +Y++M +CW P RPSFT EL+ ILG
Sbjct: 744 KQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILG 783
Score = 41.9 bits (94), Expect = 0.013
Identities = 37/128 (28%), Positives = 62/128 (48%), Gaps = 9/128 (7%)
Query: 586 NLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMV 645
+LGI ++ L E P ++ T G+ LG G FG V +A+ + + V VAVKM+
Sbjct: 489 SLGISDE--LKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFV--KVAVKML 544
Query: 646 KR-TADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKREL---IVIVEYCKYGNI 701
K + I+ E M H ++ L+G + AK L +VI+ + K+G++
Sbjct: 545 KADIIASSDIEEFLREAACMKEF-DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDL 603
Query: 702 HNYMQKHR 709
H ++ R
Sbjct: 604 HAFLLASR 611
Score = 37.1 bits (82), Expect = 0.37
Identities = 16/65 (24%), Positives = 34/65 (52%), Gaps = 3/65 (4%)
Query: 448 EGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDN 507
+G+ ++L+C EG+ P I W KD ++ N +L++ + + +++++ D
Sbjct: 48 QGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLD--QLYIPVSEQHWI-GFLSLKSVERSDA 104
Query: 508 GIYEC 512
G Y C
Sbjct: 105 GRYWC 109
>U05682-1|AAA19236.1| 890|Homo sapiens Rse protein.
Length = 890
Score = 160 bits (388), Expect = 3e-38
Identities = 71/160 (44%), Positives = 108/160 (67%), Gaps = 4/160 (2%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ + IA GMEYL++R +H DLAARN +LA+D V + DFGL+R +Y+ + Y++
Sbjct: 632 LIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCA 691
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
S LPVKWLA+E + D +++ QSDVW++G+ +WE+ + +TPY I ++ +L GNRL
Sbjct: 692 SKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRL 751
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFT----ELQEILG 957
++PP + +Y++M +CW P RPSFT EL+ ILG
Sbjct: 752 KQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILG 791
Score = 41.9 bits (94), Expect = 0.013
Identities = 37/128 (28%), Positives = 62/128 (48%), Gaps = 9/128 (7%)
Query: 586 NLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMV 645
+LGI ++ L E P ++ T G+ LG G FG V +A+ + + V VAVKM+
Sbjct: 497 SLGISDE--LKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFV--KVAVKML 552
Query: 646 KR-TADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKREL---IVIVEYCKYGNI 701
K + I+ E M H ++ L+G + AK L +VI+ + K+G++
Sbjct: 553 KADIIASSDIEEFLREAACMKEF-DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDL 611
Query: 702 HNYMQKHR 709
H ++ R
Sbjct: 612 HAFLLASR 619
Score = 37.1 bits (82), Expect = 0.37
Identities = 16/65 (24%), Positives = 34/65 (52%), Gaps = 3/65 (4%)
Query: 448 EGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDN 507
+G+ ++L+C EG+ P I W KD ++ N +L++ + + +++++ D
Sbjct: 56 QGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLD--QLYIPVSEQHWI-GFLSLKSVERSDA 112
Query: 508 GIYEC 512
G Y C
Sbjct: 113 GRYWC 117
>D50479-1|BAA21781.1| 884|Homo sapiens protein-tyrosine kinase
protein.
Length = 884
Score = 160 bits (388), Expect = 3e-38
Identities = 71/160 (44%), Positives = 108/160 (67%), Gaps = 4/160 (2%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ + IA GMEYL++R +H DLAARN +LA+D V + DFGL+R +Y+ + Y++
Sbjct: 626 LIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCA 685
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
S LPVKWLA+E + D +++ QSDVW++G+ +WE+ + +TPY I ++ +L GNRL
Sbjct: 686 SKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRL 745
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFT----ELQEILG 957
++PP + +Y++M +CW P RPSFT EL+ ILG
Sbjct: 746 KQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILG 785
Score = 41.9 bits (94), Expect = 0.013
Identities = 37/128 (28%), Positives = 62/128 (48%), Gaps = 9/128 (7%)
Query: 586 NLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMV 645
+LGI ++ L E P ++ T G+ LG G FG V +A+ + + V VAVKM+
Sbjct: 491 SLGISDE--LKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFV--KVAVKML 546
Query: 646 KR-TADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKREL---IVIVEYCKYGNI 701
K + I+ E M H ++ L+G + AK L +VI+ + K+G++
Sbjct: 547 KADIIASSDIEEFLREAACMKEF-DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDL 605
Query: 702 HNYMQKHR 709
H ++ R
Sbjct: 606 HAFLLASR 613
Score = 37.1 bits (82), Expect = 0.37
Identities = 16/65 (24%), Positives = 34/65 (52%), Gaps = 3/65 (4%)
Query: 448 EGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDN 507
+G+ ++L+C EG+ P I W KD ++ N +L++ + + +++++ D
Sbjct: 50 QGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLD--QLYIPVSEQHWI-GFLSLKSVERSDA 106
Query: 508 GIYEC 512
G Y C
Sbjct: 107 GRYWC 111
>D17517-1|BAA04467.1| 890|Homo sapiens Sky protein.
Length = 890
Score = 160 bits (388), Expect = 3e-38
Identities = 71/160 (44%), Positives = 108/160 (67%), Gaps = 4/160 (2%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ + IA GMEYL++R +H DLAARN +LA+D V + DFGL+R +Y+ + Y++
Sbjct: 632 LIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCA 691
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
S LPVKWLA+E + D +++ QSDVW++G+ +WE+ + +TPY I ++ +L GNRL
Sbjct: 692 SKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRL 751
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFT----ELQEILG 957
++PP + +Y++M +CW P RPSFT EL+ ILG
Sbjct: 752 KQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILG 791
Score = 41.9 bits (94), Expect = 0.013
Identities = 37/128 (28%), Positives = 62/128 (48%), Gaps = 9/128 (7%)
Query: 586 NLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMV 645
+LGI ++ L E P ++ T G+ LG G FG V +A+ + + V VAVKM+
Sbjct: 497 SLGISDE--LKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFV--KVAVKML 552
Query: 646 KR-TADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKREL---IVIVEYCKYGNI 701
K + I+ E M H ++ L+G + AK L +VI+ + K+G++
Sbjct: 553 KADIIASSDIEEFLREAACMKEF-DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDL 611
Query: 702 HNYMQKHR 709
H ++ R
Sbjct: 612 HAFLLASR 619
Score = 37.1 bits (82), Expect = 0.37
Identities = 16/65 (24%), Positives = 34/65 (52%), Gaps = 3/65 (4%)
Query: 448 EGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDN 507
+G+ ++L+C EG+ P I W KD ++ N +L++ + + +++++ D
Sbjct: 56 QGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLD--QLYIPVSEQHWI-GFLSLKSVERSDA 112
Query: 508 GIYEC 512
G Y C
Sbjct: 113 GRYWC 117
>BC051756-1|AAH51756.1| 890|Homo sapiens TYRO3 protein tyrosine
kinase protein.
Length = 890
Score = 160 bits (388), Expect = 3e-38
Identities = 71/160 (44%), Positives = 108/160 (67%), Gaps = 4/160 (2%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ + IA GMEYL++R +H DLAARN +LA+D V + DFGL+R +Y+ + Y++
Sbjct: 632 LIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCA 691
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
S LPVKWLA+E + D +++ QSDVW++G+ +WE+ + +TPY I ++ +L GNRL
Sbjct: 692 SKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRL 751
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFT----ELQEILG 957
++PP + +Y++M +CW P RPSFT EL+ ILG
Sbjct: 752 KQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILG 791
Score = 41.9 bits (94), Expect = 0.013
Identities = 37/128 (28%), Positives = 62/128 (48%), Gaps = 9/128 (7%)
Query: 586 NLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMV 645
+LGI ++ L E P ++ T G+ LG G FG V +A+ + + V VAVKM+
Sbjct: 497 SLGISDE--LKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFV--KVAVKML 552
Query: 646 KR-TADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKREL---IVIVEYCKYGNI 701
K + I+ E M H ++ L+G + AK L +VI+ + K+G++
Sbjct: 553 KADIIASSDIEEFLREAACMKEF-DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDL 611
Query: 702 HNYMQKHR 709
H ++ R
Sbjct: 612 HAFLLASR 619
Score = 37.1 bits (82), Expect = 0.37
Identities = 16/65 (24%), Positives = 34/65 (52%), Gaps = 3/65 (4%)
Query: 448 EGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDN 507
+G+ ++L+C EG+ P I W KD ++ N +L++ + + +++++ D
Sbjct: 56 QGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLD--QLYIPVSEQHWI-GFLSLKSVERSDA 112
Query: 508 GIYEC 512
G Y C
Sbjct: 113 GRYWC 117
>BC049368-1|AAH49368.1| 890|Homo sapiens TYRO3 protein tyrosine
kinase protein.
Length = 890
Score = 160 bits (388), Expect = 3e-38
Identities = 71/160 (44%), Positives = 108/160 (67%), Gaps = 4/160 (2%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ + IA GMEYL++R +H DLAARN +LA+D V + DFGL+R +Y+ + Y++
Sbjct: 632 LIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCA 691
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
S LPVKWLA+E + D +++ QSDVW++G+ +WE+ + +TPY I ++ +L GNRL
Sbjct: 692 SKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRL 751
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFT----ELQEILG 957
++PP + +Y++M +CW P RPSFT EL+ ILG
Sbjct: 752 KQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILG 791
Score = 42.3 bits (95), Expect = 0.010
Identities = 37/128 (28%), Positives = 63/128 (49%), Gaps = 9/128 (7%)
Query: 586 NLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMV 645
+LGI ++ L E P ++ T G+ LG G FG V +A+ + ++ V VAVKM+
Sbjct: 497 SLGISDE--LKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDSSFV--KVAVKML 552
Query: 646 KR-TADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKREL---IVIVEYCKYGNI 701
K + I+ E M H ++ L+G + AK L +VI+ + K+G++
Sbjct: 553 KADIIASSDIEEFLREAACMKEF-DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDL 611
Query: 702 HNYMQKHR 709
H ++ R
Sbjct: 612 HAFLLASR 619
Score = 37.1 bits (82), Expect = 0.37
Identities = 16/65 (24%), Positives = 34/65 (52%), Gaps = 3/65 (4%)
Query: 448 EGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDN 507
+G+ ++L+C EG+ P I W KD ++ N +L++ + + +++++ D
Sbjct: 56 QGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLD--QLYIPVSEQHWI-GFLSLKSVERSDA 112
Query: 508 GIYEC 512
G Y C
Sbjct: 113 GRYWC 117
>BC029925-1|AAH29925.2| 518|Homo sapiens TYRO3 protein protein.
Length = 518
Score = 160 bits (388), Expect = 3e-38
Identities = 71/160 (44%), Positives = 108/160 (67%), Gaps = 4/160 (2%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ + IA GMEYL++R +H DLAARN +LA+D V + DFGL+R +Y+ + Y++
Sbjct: 260 LIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCA 319
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
S LPVKWLA+E + D +++ QSDVW++G+ +WE+ + +TPY I ++ +L GNRL
Sbjct: 320 SKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRL 379
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFT----ELQEILG 957
++PP + +Y++M +CW P RPSFT EL+ ILG
Sbjct: 380 KQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILG 419
Score = 41.9 bits (94), Expect = 0.013
Identities = 37/128 (28%), Positives = 62/128 (48%), Gaps = 9/128 (7%)
Query: 586 NLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMV 645
+LGI ++ L E P ++ T G+ LG G FG V +A+ + + V VAVKM+
Sbjct: 125 SLGISDE--LKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFV--KVAVKML 180
Query: 646 KR-TADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKREL---IVIVEYCKYGNI 701
K + I+ E M H ++ L+G + AK L +VI+ + K+G++
Sbjct: 181 KADIIASSDIEEFLREAACMKEF-DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDL 239
Query: 702 HNYMQKHR 709
H ++ R
Sbjct: 240 HAFLLASR 247
>AB209431-1|BAD92668.1| 951|Homo sapiens TYRO3 protein tyrosine
kinase variant protein.
Length = 951
Score = 160 bits (388), Expect = 3e-38
Identities = 71/160 (44%), Positives = 108/160 (67%), Gaps = 4/160 (2%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ + IA GMEYL++R +H DLAARN +LA+D V + DFGL+R +Y+ + Y++
Sbjct: 693 LIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCA 752
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
S LPVKWLA+E + D +++ QSDVW++G+ +WE+ + +TPY I ++ +L GNRL
Sbjct: 753 SKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRL 812
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFT----ELQEILG 957
++PP + +Y++M +CW P RPSFT EL+ ILG
Sbjct: 813 KQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILG 852
Score = 41.9 bits (94), Expect = 0.013
Identities = 37/128 (28%), Positives = 62/128 (48%), Gaps = 9/128 (7%)
Query: 586 NLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMV 645
+LGI ++ L E P ++ T G+ LG G FG V +A+ + + V VAVKM+
Sbjct: 558 SLGISDE--LKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFV--KVAVKML 613
Query: 646 KR-TADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKREL---IVIVEYCKYGNI 701
K + I+ E M H ++ L+G + AK L +VI+ + K+G++
Sbjct: 614 KADIIASSDIEEFLREAACMKEF-DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDL 672
Query: 702 HNYMQKHR 709
H ++ R
Sbjct: 673 HAFLLASR 680
Score = 37.1 bits (82), Expect = 0.37
Identities = 16/65 (24%), Positives = 34/65 (52%), Gaps = 3/65 (4%)
Query: 448 EGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDN 507
+G+ ++L+C EG+ P I W KD ++ N +L++ + + +++++ D
Sbjct: 117 QGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLD--QLYIPVSEQHWI-GFLSLKSVERSDA 173
Query: 508 GIYEC 512
G Y C
Sbjct: 174 GRYWC 178
>BC114918-1|AAI14919.1| 823|Homo sapiens MERTK protein protein.
Length = 823
Score = 158 bits (383), Expect = 1e-37
Identities = 69/168 (41%), Positives = 108/168 (64%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P+ + LL + IA GMEYL+NR LH DLAARN +L DD V + DFGL++ +Y+
Sbjct: 516 PKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSG 575
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
+ Y++ + +PVKW+AIE + DR+++++SDVW++G+ +WE+ + TPYP + ++
Sbjct: 576 DYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYD 635
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
+L G+RL++P D LY +M CW P RP+F+ L+ L LE
Sbjct: 636 YLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLE 683
Score = 45.6 bits (103), Expect = 0.001
Identities = 37/123 (30%), Positives = 58/123 (47%), Gaps = 8/123 (6%)
Query: 586 NLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMV 645
+LG+ E+ L E R L GK LG G FG V + + + VAVK +
Sbjct: 390 SLGVSEE--LQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQ--EDGTSLKVAVKTM 445
Query: 646 KR-TADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKR--ELIVIVEYCKYGNIH 702
K + I+ SE M H N++ LLG C + ++ + +VI+ + KYG++H
Sbjct: 446 KLDNSSQREIEEFLSEAACMKDFS-HPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLH 504
Query: 703 NYM 705
Y+
Sbjct: 505 TYL 507
>BC114917-1|AAI14918.1| 823|Homo sapiens MERTK protein protein.
Length = 823
Score = 158 bits (383), Expect = 1e-37
Identities = 69/168 (41%), Positives = 108/168 (64%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P+ + LL + IA GMEYL+NR LH DLAARN +L DD V + DFGL++ +Y+
Sbjct: 516 PKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSG 575
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
+ Y++ + +PVKW+AIE + DR+++++SDVW++G+ +WE+ + TPYP + ++
Sbjct: 576 DYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYD 635
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
+L G+RL++P D LY +M CW P RP+F+ L+ L LE
Sbjct: 636 YLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLE 683
Score = 45.6 bits (103), Expect = 0.001
Identities = 37/123 (30%), Positives = 58/123 (47%), Gaps = 8/123 (6%)
Query: 586 NLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMV 645
+LG+ E+ L E R L GK LG G FG V + + + VAVK +
Sbjct: 390 SLGVSEE--LQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQ--EDGTSLKVAVKTM 445
Query: 646 KR-TADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKR--ELIVIVEYCKYGNIH 702
K + I+ SE M H N++ LLG C + ++ + +VI+ + KYG++H
Sbjct: 446 KLDNSSQREIEEFLSEAACMKDFS-HPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLH 504
Query: 703 NYM 705
Y+
Sbjct: 505 TYL 507
>AF260529-1|AAG33129.1| 978|Homo sapiens MER receptor tyrosine
kinase protein.
Length = 978
Score = 158 bits (383), Expect = 1e-37
Identities = 69/168 (41%), Positives = 108/168 (64%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P+ + LL + IA GMEYL+NR LH DLAARN +L DD V + DFGL++ +Y+
Sbjct: 671 PKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSG 730
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
+ Y++ + +PVKW+AIE + DR+++++SDVW++G+ +WE+ + TPYP + ++
Sbjct: 731 DYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYD 790
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
+L G+RL++P D LY +M CW P RP+F+ L+ L LE
Sbjct: 791 YLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLE 838
Score = 45.6 bits (103), Expect = 0.001
Identities = 37/123 (30%), Positives = 58/123 (47%), Gaps = 8/123 (6%)
Query: 586 NLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMV 645
+LG+ E+ L E R L GK LG G FG V + + + VAVK +
Sbjct: 545 SLGVSEE--LQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQ--EDGTSLKVAVKTM 600
Query: 646 KR-TADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKR--ELIVIVEYCKYGNIH 702
K + I+ SE M H N++ LLG C + ++ + +VI+ + KYG++H
Sbjct: 601 KLDNSSQREIEEFLSEAACMKDFS-HPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLH 659
Query: 703 NYM 705
Y+
Sbjct: 660 TYL 662
Score = 33.5 bits (73), Expect = 4.5
Identities = 19/55 (34%), Positives = 29/55 (52%), Gaps = 2/55 (3%)
Query: 465 TIYWYKDD-ELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIYEC-VALNN 517
TI W+KD EL+ + F T + ++F I ++Q DNG Y C + +NN
Sbjct: 106 TISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKINN 160
>AC093675-1|AAY24213.1| 567|Homo sapiens unknown protein.
Length = 567
Score = 158 bits (383), Expect = 1e-37
Identities = 69/168 (41%), Positives = 108/168 (64%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P+ + LL + IA GMEYL+NR LH DLAARN +L DD V + DFGL++ +Y+
Sbjct: 260 PKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSG 319
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
+ Y++ + +PVKW+AIE + DR+++++SDVW++G+ +WE+ + TPYP + ++
Sbjct: 320 DYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYD 379
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
+L G+RL++P D LY +M CW P RP+F+ L+ L LE
Sbjct: 380 YLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLE 427
Score = 45.6 bits (103), Expect = 0.001
Identities = 37/123 (30%), Positives = 58/123 (47%), Gaps = 8/123 (6%)
Query: 586 NLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMV 645
+LG+ E+ L E R L GK LG G FG V + + + VAVK +
Sbjct: 134 SLGVSEE--LQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQ--EDGTSLKVAVKTM 189
Query: 646 KR-TADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKR--ELIVIVEYCKYGNIH 702
K + I+ SE M H N++ LLG C + ++ + +VI+ + KYG++H
Sbjct: 190 KLDNSSQREIEEFLSEAACMKDFS-HPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLH 248
Query: 703 NYM 705
Y+
Sbjct: 249 TYL 251
>U08023-1|AAB60430.1| 999|Homo sapiens c-mer protein.
Length = 999
Score = 157 bits (382), Expect = 2e-37
Identities = 69/168 (41%), Positives = 108/168 (64%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P+ + LL + IA GMEYL+NR LH DLAARN +L DD V + DFGL++ +Y+
Sbjct: 692 PKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSG 751
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
+ Y++ + +PVKW+AIE + DR+++++SDVW++G+ +WE+ + TPYP + ++
Sbjct: 752 DYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIRTRGMTPYPGVQNHEMYD 811
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLE 961
+L G+RL++P D LY +M CW P RP+F+ L+ L LE
Sbjct: 812 YLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLE 859
Score = 46.0 bits (104), Expect = 8e-04
Identities = 37/123 (30%), Positives = 59/123 (47%), Gaps = 8/123 (6%)
Query: 586 NLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMV 645
+LG+ E+ L E R L GK LG G FG V + + + VAVK +
Sbjct: 566 SLGVSEE--LQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQ--EDGTSLKVAVKTM 621
Query: 646 KR-TADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKR--ELIVIVEYCKYGNIH 702
K + + I+ SE M H N++ LLG C + ++ + +VI+ + KYG++H
Sbjct: 622 KLDNSSHREIEEFLSEAACMKDFS-HPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLH 680
Query: 703 NYM 705
Y+
Sbjct: 681 TYL 683
Score = 33.5 bits (73), Expect = 4.5
Identities = 19/55 (34%), Positives = 29/55 (52%), Gaps = 2/55 (3%)
Query: 465 TIYWYKDD-ELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIYEC-VALNN 517
TI W+KD EL+ + F T + ++F I ++Q DNG Y C + +NN
Sbjct: 127 TISWWKDGKELLGGHHRITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKINN 181
>BC109099-1|AAI09100.1| 773|Homo sapiens MUSK protein protein.
Length = 773
Score = 156 bits (379), Expect = 4e-37
Identities = 72/171 (42%), Positives = 106/171 (61%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P PL+ L A Q+A GM YL+ RK +H DLA RN L+ ++ VVKI DFGL+R++Y+
Sbjct: 598 PPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSA 657
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
+ Y+ EN +P++W+ E + ++T+SDVW+YG+VLWE+FS PY ++ +++
Sbjct: 658 DYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIY 717
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
++ DGN L P LYN+M CW + P RPSFT + IL E E
Sbjct: 718 YVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCERAE 768
Score = 62.1 bits (144), Expect = 1e-08
Identities = 34/104 (32%), Positives = 56/104 (53%), Gaps = 4/104 (3%)
Query: 603 EFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELK 662
E+PR + + + +G GAFG V++A A G++ E T VAVKM+K A E
Sbjct: 473 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAA 532
Query: 663 IMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
+M + NIV LLG C + + ++ EY YG+++ +++
Sbjct: 533 LMAEF-DNPNIVKLLGVCA---VGKPMCLLFEYMAYGDLNEFLR 572
Score = 50.4 bits (115), Expect = 4e-05
Identities = 56/228 (24%), Positives = 98/228 (42%), Gaps = 18/228 (7%)
Query: 151 QNITIRNATKKHNGVYTCLLTNTCGEEKDEFRKIFLE-KPFLSLRDLAKGKLMGNANKSI 209
Q +TI + +G+Y C N G + + ++ KP ++ R K++ +
Sbjct: 82 QLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKIT-RPPINVKIIEGLKAVL 140
Query: 210 NIVIEIEAYPPVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVA 269
P V ++K D L N + L +G LRI++++ D Y VA
Sbjct: 141 PCTTMGNPKPSVS---WIKGDSPLRENS---RIAVLESGS--LRIHNVQKEDAGQYRCVA 192
Query: 270 ENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRLE-NSEMNFACKVTGYPLPDVTWIFSNDE 328
+N T Y+ +++ + A++L + S + C TG P+P +TWI E
Sbjct: 193 KNSLGTA-YSKVVKLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITWI----E 247
Query: 329 EHELSSTKSEQESLYAKT--DYLKISVQASGVITCNAHNSKGEYFDSS 374
S+ S QES+ + L++ + G+ TC A N GE F ++
Sbjct: 248 NGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTA 295
Score = 47.6 bits (108), Expect = 3e-04
Identities = 27/94 (28%), Positives = 48/94 (51%), Gaps = 10/94 (10%)
Query: 427 DIELLAPIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVD 486
++E+ A I+R P+S+ G + LHC A G+P PTI W ++ +S+ S +
Sbjct: 207 EVEVFARILRAPESHN---VTFGSFVTLHCTATGIPVPTITWIENGNAVSSGS----IQE 259
Query: 487 IVNHTIVNSTFEIENMQEKDNGIYECVALNNASE 520
V +++S ++ + G+Y C+A N E
Sbjct: 260 SVKDRVIDSRLQLFITKP---GLYTCIATNKHGE 290
Score = 46.4 bits (105), Expect = 6e-04
Identities = 32/102 (31%), Positives = 49/102 (48%), Gaps = 13/102 (12%)
Query: 431 LAPIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNH 490
+ P I P N + +EG L C G P+P++ W K D + NS +
Sbjct: 119 MKPKITRPPINV--KIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAV------- 169
Query: 491 TIVNSTFEIENMQEKDNGIYECVALNNASELRRAYTLVLKAE 532
+ + + I N+Q++D G Y CVA N+ L AY+ V+K E
Sbjct: 170 -LESGSLRIHNVQKEDAGQYRCVAKNS---LGTAYSKVVKLE 207
>BC109098-1|AAI09099.1| 783|Homo sapiens MUSK protein protein.
Length = 783
Score = 156 bits (379), Expect = 4e-37
Identities = 72/171 (42%), Positives = 106/171 (61%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P PL+ L A Q+A GM YL+ RK +H DLA RN L+ ++ VVKI DFGL+R++Y+
Sbjct: 608 PPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSA 667
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
+ Y+ EN +P++W+ E + ++T+SDVW+YG+VLWE+FS PY ++ +++
Sbjct: 668 DYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIY 727
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
++ DGN L P LYN+M CW + P RPSFT + IL E E
Sbjct: 728 YVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCERAE 778
Score = 62.1 bits (144), Expect = 1e-08
Identities = 34/104 (32%), Positives = 56/104 (53%), Gaps = 4/104 (3%)
Query: 603 EFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELK 662
E+PR + + + +G GAFG V++A A G++ E T VAVKM+K A E
Sbjct: 483 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAA 542
Query: 663 IMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
+M + NIV LLG C + + ++ EY YG+++ +++
Sbjct: 543 LMAEF-DNPNIVKLLGVCA---VGKPMCLLFEYMAYGDLNEFLR 582
Score = 50.8 bits (116), Expect = 3e-05
Identities = 59/237 (24%), Positives = 102/237 (43%), Gaps = 26/237 (10%)
Query: 151 QNITIRNATKKHNGVYTCLLTNTCGEEKDEFRKIFLE-KPFLSLRDLAKGKLMGNANKSI 209
Q +TI + +G+Y C N G + + ++ KP ++ R K++ +
Sbjct: 82 QLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKIT-RPPINVKIIEGLKAVL 140
Query: 210 NIVIEIEAYPPVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVA 269
P V ++K D L N + L +G LRI++++ D Y VA
Sbjct: 141 PCTTMGNPKPSVS---WIKGDSPLRENS---RIAVLESGS--LRIHNVQKEDAGQYRCVA 192
Query: 270 ENKYLT---KNYTVDLRVFTKPEAKL-LNNRIIKRLENSEMNFA------CKVTGYPLPD 319
+N T K +++ ++PE + RI++ E+ + F C TG P+P
Sbjct: 193 KNSLGTAYSKVVKLEVEEESEPEQDTKVFARILRAPESHNVTFGSFVTLHCTATGIPVPT 252
Query: 320 VTWIFSNDEEHELSSTKSEQESLYAKT--DYLKISVQASGVITCNAHNSKGEYFDSS 374
+TWI E S+ S QES+ + L++ + G+ TC A N GE F ++
Sbjct: 253 ITWI----ENGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTA 305
Score = 46.4 bits (105), Expect = 6e-04
Identities = 32/102 (31%), Positives = 49/102 (48%), Gaps = 13/102 (12%)
Query: 431 LAPIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNH 490
+ P I P N + +EG L C G P+P++ W K D + NS +
Sbjct: 119 MKPKITRPPINV--KIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAV------- 169
Query: 491 TIVNSTFEIENMQEKDNGIYECVALNNASELRRAYTLVLKAE 532
+ + + I N+Q++D G Y CVA N+ L AY+ V+K E
Sbjct: 170 -LESGSLRIHNVQKEDAGQYRCVAKNS---LGTAYSKVVKLE 207
Score = 46.0 bits (104), Expect = 8e-04
Identities = 27/94 (28%), Positives = 47/94 (50%), Gaps = 10/94 (10%)
Query: 427 DIELLAPIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVD 486
D ++ A I+R P+S+ G + LHC A G+P PTI W ++ +S+ S +
Sbjct: 217 DTKVFARILRAPESHN---VTFGSFVTLHCTATGIPVPTITWIENGNAVSSGS----IQE 269
Query: 487 IVNHTIVNSTFEIENMQEKDNGIYECVALNNASE 520
V +++S ++ + G+Y C+A N E
Sbjct: 270 SVKDRVIDSRLQLFITKP---GLYTCIATNKHGE 300
>AL513328-2|CAI17350.1| 867|Homo sapiens muscle, skeletal, receptor
tyrosine kinase protein.
Length = 867
Score = 156 bits (379), Expect = 4e-37
Identities = 72/171 (42%), Positives = 106/171 (61%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P PL+ L A Q+A GM YL+ RK +H DLA RN L+ ++ VVKI DFGL+R++Y+
Sbjct: 692 PPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSA 751
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
+ Y+ EN +P++W+ E + ++T+SDVW+YG+VLWE+FS PY ++ +++
Sbjct: 752 DYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIY 811
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
++ DGN L P LYN+M CW + P RPSFT + IL E E
Sbjct: 812 YVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCERAE 862
Score = 62.1 bits (144), Expect = 1e-08
Identities = 34/104 (32%), Positives = 56/104 (53%), Gaps = 4/104 (3%)
Query: 603 EFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELK 662
E+PR + + + +G GAFG V++A A G++ E T VAVKM+K A E
Sbjct: 567 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAA 626
Query: 663 IMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
+M + NIV LLG C + + ++ EY YG+++ +++
Sbjct: 627 LMAEF-DNPNIVKLLGVCA---VGKPMCLLFEYMAYGDLNEFLR 666
Score = 50.4 bits (115), Expect = 4e-05
Identities = 56/228 (24%), Positives = 98/228 (42%), Gaps = 18/228 (7%)
Query: 151 QNITIRNATKKHNGVYTCLLTNTCGEEKDEFRKIFLE-KPFLSLRDLAKGKLMGNANKSI 209
Q +TI + +G+Y C N G + + ++ KP ++ R K++ +
Sbjct: 82 QLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKIT-RPPINVKIIEGLKAVL 140
Query: 210 NIVIEIEAYPPVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVA 269
P V ++K D L N + L +G LRI++++ D Y VA
Sbjct: 141 PCTTMGNPKPSVS---WIKGDSPLRENS---RIAVLESGS--LRIHNVQKEDAGQYRCVA 192
Query: 270 ENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRLE-NSEMNFACKVTGYPLPDVTWIFSNDE 328
+N T Y+ +++ + A++L + S + C TG P+P +TWI E
Sbjct: 193 KNSLGTA-YSKVVKLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITWI----E 247
Query: 329 EHELSSTKSEQESLYAKT--DYLKISVQASGVITCNAHNSKGEYFDSS 374
S+ S QES+ + L++ + G+ TC A N GE F ++
Sbjct: 248 NGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTA 295
Score = 47.6 bits (108), Expect = 3e-04
Identities = 27/94 (28%), Positives = 48/94 (51%), Gaps = 10/94 (10%)
Query: 427 DIELLAPIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVD 486
++E+ A I+R P+S+ G + LHC A G+P PTI W ++ +S+ S +
Sbjct: 207 EVEVFARILRAPESHN---VTFGSFVTLHCTATGIPVPTITWIENGNAVSSGS----IQE 259
Query: 487 IVNHTIVNSTFEIENMQEKDNGIYECVALNNASE 520
V +++S ++ + G+Y C+A N E
Sbjct: 260 SVKDRVIDSRLQLFITKP---GLYTCIATNKHGE 290
Score = 46.4 bits (105), Expect = 6e-04
Identities = 32/102 (31%), Positives = 49/102 (48%), Gaps = 13/102 (12%)
Query: 431 LAPIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNH 490
+ P I P N + +EG L C G P+P++ W K D + NS +
Sbjct: 119 MKPKITRPPINV--KIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAV------- 169
Query: 491 TIVNSTFEIENMQEKDNGIYECVALNNASELRRAYTLVLKAE 532
+ + + I N+Q++D G Y CVA N+ L AY+ V+K E
Sbjct: 170 -LESGSLRIHNVQKEDAGQYRCVAKNS---LGTAYSKVVKLE 207
>AL513328-1|CAI17349.1| 875|Homo sapiens muscle, skeletal, receptor
tyrosine kinase protein.
Length = 875
Score = 156 bits (379), Expect = 4e-37
Identities = 72/171 (42%), Positives = 106/171 (61%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P PL+ L A Q+A GM YL+ RK +H DLA RN L+ ++ VVKI DFGL+R++Y+
Sbjct: 700 PPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSA 759
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
+ Y+ EN +P++W+ E + ++T+SDVW+YG+VLWE+FS PY ++ +++
Sbjct: 760 DYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIY 819
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
++ DGN L P LYN+M CW + P RPSFT + IL E E
Sbjct: 820 YVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCERAE 870
Score = 62.1 bits (144), Expect = 1e-08
Identities = 34/104 (32%), Positives = 56/104 (53%), Gaps = 4/104 (3%)
Query: 603 EFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELK 662
E+PR + + + +G GAFG V++A A G++ E T VAVKM+K A E
Sbjct: 575 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAA 634
Query: 663 IMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
+M + NIV LLG C + + ++ EY YG+++ +++
Sbjct: 635 LMAEF-DNPNIVKLLGVCA---VGKPMCLLFEYMAYGDLNEFLR 674
Score = 50.4 bits (115), Expect = 4e-05
Identities = 56/228 (24%), Positives = 98/228 (42%), Gaps = 18/228 (7%)
Query: 151 QNITIRNATKKHNGVYTCLLTNTCGEEKDEFRKIFLE-KPFLSLRDLAKGKLMGNANKSI 209
Q +TI + +G+Y C N G + + ++ KP ++ R K++ +
Sbjct: 82 QLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKIT-RPPINVKIIEGLKAVL 140
Query: 210 NIVIEIEAYPPVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVA 269
P V ++K D L N + L +G LRI++++ D Y VA
Sbjct: 141 PCTTMGNPKPSVS---WIKGDSPLRENS---RIAVLESGS--LRIHNVQKEDAGQYRCVA 192
Query: 270 ENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRLE-NSEMNFACKVTGYPLPDVTWIFSNDE 328
+N T Y+ +++ + A++L + S + C TG P+P +TWI E
Sbjct: 193 KNSLGTA-YSKVVKLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITWI----E 247
Query: 329 EHELSSTKSEQESLYAKT--DYLKISVQASGVITCNAHNSKGEYFDSS 374
S+ S QES+ + L++ + G+ TC A N GE F ++
Sbjct: 248 NGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTA 295
Score = 47.6 bits (108), Expect = 3e-04
Identities = 27/94 (28%), Positives = 48/94 (51%), Gaps = 10/94 (10%)
Query: 427 DIELLAPIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVD 486
++E+ A I+R P+S+ G + LHC A G+P PTI W ++ +S+ S +
Sbjct: 207 EVEVFARILRAPESHN---VTFGSFVTLHCTATGIPVPTITWIENGNAVSSGS----IQE 259
Query: 487 IVNHTIVNSTFEIENMQEKDNGIYECVALNNASE 520
V +++S ++ + G+Y C+A N E
Sbjct: 260 SVKDRVIDSRLQLFITKP---GLYTCIATNKHGE 290
Score = 46.4 bits (105), Expect = 6e-04
Identities = 32/102 (31%), Positives = 49/102 (48%), Gaps = 13/102 (12%)
Query: 431 LAPIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNH 490
+ P I P N + +EG L C G P+P++ W K D + NS +
Sbjct: 119 MKPKITRPPINV--KIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAV------- 169
Query: 491 TIVNSTFEIENMQEKDNGIYECVALNNASELRRAYTLVLKAE 532
+ + + I N+Q++D G Y CVA N+ L AY+ V+K E
Sbjct: 170 -LESGSLRIHNVQKEDAGQYRCVAKNS---LGTAYSKVVKLE 207
>AL157881-3|CAH69978.1| 867|Homo sapiens muscle, skeletal, receptor
tyrosine kinase protein.
Length = 867
Score = 156 bits (379), Expect = 4e-37
Identities = 72/171 (42%), Positives = 106/171 (61%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P PL+ L A Q+A GM YL+ RK +H DLA RN L+ ++ VVKI DFGL+R++Y+
Sbjct: 692 PPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSA 751
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
+ Y+ EN +P++W+ E + ++T+SDVW+YG+VLWE+FS PY ++ +++
Sbjct: 752 DYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIY 811
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
++ DGN L P LYN+M CW + P RPSFT + IL E E
Sbjct: 812 YVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCERAE 862
Score = 62.1 bits (144), Expect = 1e-08
Identities = 34/104 (32%), Positives = 56/104 (53%), Gaps = 4/104 (3%)
Query: 603 EFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELK 662
E+PR + + + +G GAFG V++A A G++ E T VAVKM+K A E
Sbjct: 567 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAA 626
Query: 663 IMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
+M + NIV LLG C + + ++ EY YG+++ +++
Sbjct: 627 LMAEF-DNPNIVKLLGVCA---VGKPMCLLFEYMAYGDLNEFLR 666
Score = 50.4 bits (115), Expect = 4e-05
Identities = 56/228 (24%), Positives = 98/228 (42%), Gaps = 18/228 (7%)
Query: 151 QNITIRNATKKHNGVYTCLLTNTCGEEKDEFRKIFLE-KPFLSLRDLAKGKLMGNANKSI 209
Q +TI + +G+Y C N G + + ++ KP ++ R K++ +
Sbjct: 82 QLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKIT-RPPINVKIIEGLKAVL 140
Query: 210 NIVIEIEAYPPVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVA 269
P V ++K D L N + L +G LRI++++ D Y VA
Sbjct: 141 PCTTMGNPKPSVS---WIKGDSPLRENS---RIAVLESGS--LRIHNVQKEDAGQYRCVA 192
Query: 270 ENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRLE-NSEMNFACKVTGYPLPDVTWIFSNDE 328
+N T Y+ +++ + A++L + S + C TG P+P +TWI E
Sbjct: 193 KNSLGTA-YSKVVKLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITWI----E 247
Query: 329 EHELSSTKSEQESLYAKT--DYLKISVQASGVITCNAHNSKGEYFDSS 374
S+ S QES+ + L++ + G+ TC A N GE F ++
Sbjct: 248 NGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTA 295
Score = 47.6 bits (108), Expect = 3e-04
Identities = 27/94 (28%), Positives = 48/94 (51%), Gaps = 10/94 (10%)
Query: 427 DIELLAPIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVD 486
++E+ A I+R P+S+ G + LHC A G+P PTI W ++ +S+ S +
Sbjct: 207 EVEVFARILRAPESHN---VTFGSFVTLHCTATGIPVPTITWIENGNAVSSGS----IQE 259
Query: 487 IVNHTIVNSTFEIENMQEKDNGIYECVALNNASE 520
V +++S ++ + G+Y C+A N E
Sbjct: 260 SVKDRVIDSRLQLFITKP---GLYTCIATNKHGE 290
Score = 46.4 bits (105), Expect = 6e-04
Identities = 32/102 (31%), Positives = 49/102 (48%), Gaps = 13/102 (12%)
Query: 431 LAPIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNH 490
+ P I P N + +EG L C G P+P++ W K D + NS +
Sbjct: 119 MKPKITRPPINV--KIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAV------- 169
Query: 491 TIVNSTFEIENMQEKDNGIYECVALNNASELRRAYTLVLKAE 532
+ + + I N+Q++D G Y CVA N+ L AY+ V+K E
Sbjct: 170 -LESGSLRIHNVQKEDAGQYRCVAKNS---LGTAYSKVVKLE 207
>AL157881-2|CAH69977.1| 875|Homo sapiens muscle, skeletal, receptor
tyrosine kinase protein.
Length = 875
Score = 156 bits (379), Expect = 4e-37
Identities = 72/171 (42%), Positives = 106/171 (61%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P PL+ L A Q+A GM YL+ RK +H DLA RN L+ ++ VVKI DFGL+R++Y+
Sbjct: 700 PPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSA 759
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
+ Y+ EN +P++W+ E + ++T+SDVW+YG+VLWE+FS PY ++ +++
Sbjct: 760 DYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIY 819
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
++ DGN L P LYN+M CW + P RPSFT + IL E E
Sbjct: 820 YVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCERAE 870
Score = 62.1 bits (144), Expect = 1e-08
Identities = 34/104 (32%), Positives = 56/104 (53%), Gaps = 4/104 (3%)
Query: 603 EFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELK 662
E+PR + + + +G GAFG V++A A G++ E T VAVKM+K A E
Sbjct: 575 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAA 634
Query: 663 IMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
+M + NIV LLG C + + ++ EY YG+++ +++
Sbjct: 635 LMAEF-DNPNIVKLLGVCA---VGKPMCLLFEYMAYGDLNEFLR 674
Score = 50.4 bits (115), Expect = 4e-05
Identities = 56/228 (24%), Positives = 98/228 (42%), Gaps = 18/228 (7%)
Query: 151 QNITIRNATKKHNGVYTCLLTNTCGEEKDEFRKIFLE-KPFLSLRDLAKGKLMGNANKSI 209
Q +TI + +G+Y C N G + + ++ KP ++ R K++ +
Sbjct: 82 QLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKIT-RPPINVKIIEGLKAVL 140
Query: 210 NIVIEIEAYPPVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVA 269
P V ++K D L N + L +G LRI++++ D Y VA
Sbjct: 141 PCTTMGNPKPSVS---WIKGDSPLRENS---RIAVLESGS--LRIHNVQKEDAGQYRCVA 192
Query: 270 ENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRLE-NSEMNFACKVTGYPLPDVTWIFSNDE 328
+N T Y+ +++ + A++L + S + C TG P+P +TWI E
Sbjct: 193 KNSLGTA-YSKVVKLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITWI----E 247
Query: 329 EHELSSTKSEQESLYAKT--DYLKISVQASGVITCNAHNSKGEYFDSS 374
S+ S QES+ + L++ + G+ TC A N GE F ++
Sbjct: 248 NGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTA 295
Score = 47.6 bits (108), Expect = 3e-04
Identities = 27/94 (28%), Positives = 48/94 (51%), Gaps = 10/94 (10%)
Query: 427 DIELLAPIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVD 486
++E+ A I+R P+S+ G + LHC A G+P PTI W ++ +S+ S +
Sbjct: 207 EVEVFARILRAPESHN---VTFGSFVTLHCTATGIPVPTITWIENGNAVSSGS----IQE 259
Query: 487 IVNHTIVNSTFEIENMQEKDNGIYECVALNNASE 520
V +++S ++ + G+Y C+A N E
Sbjct: 260 SVKDRVIDSRLQLFITKP---GLYTCIATNKHGE 290
Score = 46.4 bits (105), Expect = 6e-04
Identities = 32/102 (31%), Positives = 49/102 (48%), Gaps = 13/102 (12%)
Query: 431 LAPIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNH 490
+ P I P N + +EG L C G P+P++ W K D + NS +
Sbjct: 119 MKPKITRPPINV--KIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAV------- 169
Query: 491 TIVNSTFEIENMQEKDNGIYECVALNNASELRRAYTLVLKAE 532
+ + + I N+Q++D G Y CVA N+ L AY+ V+K E
Sbjct: 170 -LESGSLRIHNVQKEDAGQYRCVAKNS---LGTAYSKVVKLE 207
>AF006464-1|AAB63044.1| 869|Homo sapiens muscle specific tyrosine
kinase receptor protein.
Length = 869
Score = 156 bits (379), Expect = 4e-37
Identities = 72/171 (42%), Positives = 106/171 (61%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P PL+ L A Q+A GM YL+ RK +H DLA RN L+ ++ VVKI DFGL+R++Y+
Sbjct: 694 PPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSA 753
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
+ Y+ EN +P++W+ E + ++T+SDVW+YG+VLWE+FS PY ++ +++
Sbjct: 754 DYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIY 813
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
++ DGN L P LYN+M CW + P RPSFT + IL E E
Sbjct: 814 YVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCERAE 864
Score = 62.1 bits (144), Expect = 1e-08
Identities = 34/104 (32%), Positives = 56/104 (53%), Gaps = 4/104 (3%)
Query: 603 EFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELK 662
E+PR + + + +G GAFG V++A A G++ E T VAVKM+K A E
Sbjct: 569 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAA 628
Query: 663 IMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
+M + NIV LLG C + + ++ EY YG+++ +++
Sbjct: 629 LMAEF-DNPNIVKLLGVCA---VGKPMCLLFEYMAYGDLNEFLR 668
Score = 50.4 bits (115), Expect = 4e-05
Identities = 56/228 (24%), Positives = 98/228 (42%), Gaps = 18/228 (7%)
Query: 151 QNITIRNATKKHNGVYTCLLTNTCGEEKDEFRKIFLE-KPFLSLRDLAKGKLMGNANKSI 209
Q +TI + +G+Y C N G + + ++ KP ++ R K++ +
Sbjct: 82 QLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKIT-RPPINVKIIEGLKAVL 140
Query: 210 NIVIEIEAYPPVERTHFLKNDKYLPSNDLKYNVTTLANGDPKLRINDLKLTDIANYTLVA 269
P V ++K D L N + L +G LRI++++ D Y VA
Sbjct: 141 PCTTMGNPKPSVS---WIKGDSPLRENS---RIAVLESGS--LRIHNVQKEDAGQYRCVA 192
Query: 270 ENKYLTKNYTVDLRVFTKPEAKLLNNRIIKRLE-NSEMNFACKVTGYPLPDVTWIFSNDE 328
+N T Y+ +++ + A++L + S + C TG P+P +TWI E
Sbjct: 193 KNSLGTA-YSKVVKLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITWI----E 247
Query: 329 EHELSSTKSEQESLYAKT--DYLKISVQASGVITCNAHNSKGEYFDSS 374
S+ S QES+ + L++ + G+ TC A N GE F ++
Sbjct: 248 NGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTA 295
Score = 47.6 bits (108), Expect = 3e-04
Identities = 27/94 (28%), Positives = 48/94 (51%), Gaps = 10/94 (10%)
Query: 427 DIELLAPIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVD 486
++E+ A I+R P+S+ G + LHC A G+P PTI W ++ +S+ S +
Sbjct: 207 EVEVFARILRAPESHN---VTFGSFVTLHCTATGIPVPTITWIENGNAVSSGS----IQE 259
Query: 487 IVNHTIVNSTFEIENMQEKDNGIYECVALNNASE 520
V +++S ++ + G+Y C+A N E
Sbjct: 260 SVKDRVIDSRLQLFITKP---GLYTCIATNKHGE 290
Score = 46.4 bits (105), Expect = 6e-04
Identities = 32/102 (31%), Positives = 49/102 (48%), Gaps = 13/102 (12%)
Query: 431 LAPIIREPDSNKDEEAMEGRSIQLHCEAEGVPRPTIYWYKDDELISNNSGYKLFVDIVNH 490
+ P I P N + +EG L C G P+P++ W K D + NS +
Sbjct: 119 MKPKITRPPINV--KIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAV------- 169
Query: 491 TIVNSTFEIENMQEKDNGIYECVALNNASELRRAYTLVLKAE 532
+ + + I N+Q++D G Y CVA N+ L AY+ V+K E
Sbjct: 170 -LESGSLRIHNVQKEDAGQYRCVAKNS---LGTAYSKVVKLE 207
>L07868-1|AAB59446.1| 1308|Homo sapiens receptor tyrosine kinase
protein.
Length = 1308
Score = 154 bits (374), Expect = 2e-36
Identities = 74/180 (41%), Positives = 106/180 (58%), Gaps = 2/180 (1%)
Query: 786 DYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFG 845
+Y++E H+ + S LL W QIA+GM YL R+++H DLAARNVL+ N VKI DFG
Sbjct: 806 EYVHE-HKDN-IGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFG 863
Query: 846 LARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN 905
LAR + +E+ + +P+KW+A+EC+ R F+ QSDVWSYG+ +WE+ + PY
Sbjct: 864 LARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDG 923
Query: 906 ISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNER 965
I ++ L G RL +PP +Y VM++CW +RP F EL D +R
Sbjct: 924 IPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQR 983
Score = 41.5 bits (93), Expect = 0.017
Identities = 34/110 (30%), Positives = 51/110 (46%), Gaps = 12/110 (10%)
Query: 613 KQLGAGAFGVVYKAEARGIINAE---VTTPVAVKMVKRTADNMYIKALASELKIMVHLGK 669
K LG+GAFG VYK GI E V PVA+K++ T E IM +
Sbjct: 722 KVLGSGAFGTVYK----GIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASM-D 776
Query: 670 HVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDN 719
H ++V LLG C + ++ + +G + Y+ +H++ QL N
Sbjct: 777 HPHLVRLLGVCLSPTIQ----LVTQLMPHGCLLEYVHEHKDNIGSQLLLN 822
>BC112199-1|AAI12200.1| 1308|Homo sapiens v-erb-a erythroblastic
leukemia viral oncogene homolog 4 (avian) protein.
Length = 1308
Score = 154 bits (374), Expect = 2e-36
Identities = 74/180 (41%), Positives = 106/180 (58%), Gaps = 2/180 (1%)
Query: 786 DYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFG 845
+Y++E H+ + S LL W QIA+GM YL R+++H DLAARNVL+ N VKI DFG
Sbjct: 806 EYVHE-HKDN-IGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFG 863
Query: 846 LARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN 905
LAR + +E+ + +P+KW+A+EC+ R F+ QSDVWSYG+ +WE+ + PY
Sbjct: 864 LARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDG 923
Query: 906 ISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNER 965
I ++ L G RL +PP +Y VM++CW +RP F EL D +R
Sbjct: 924 IPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQR 983
Score = 41.5 bits (93), Expect = 0.017
Identities = 34/110 (30%), Positives = 51/110 (46%), Gaps = 12/110 (10%)
Query: 613 KQLGAGAFGVVYKAEARGIINAE---VTTPVAVKMVKRTADNMYIKALASELKIMVHLGK 669
K LG+GAFG VYK GI E V PVA+K++ T E IM +
Sbjct: 722 KVLGSGAFGTVYK----GIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASM-D 776
Query: 670 HVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDN 719
H ++V LLG C + ++ + +G + Y+ +H++ QL N
Sbjct: 777 HPHLVRLLGVCLSPTIQ----LVTQLMPHGCLLEYVHEHKDNIGSQLLLN 822
>AB209697-1|BAD92934.1| 892|Homo sapiens v-erb-a erythroblastic
leukemia viral oncogene homolog 4 variant protein.
Length = 892
Score = 154 bits (374), Expect = 2e-36
Identities = 74/180 (41%), Positives = 106/180 (58%), Gaps = 2/180 (1%)
Query: 786 DYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFG 845
+Y++E H+ + S LL W QIA+GM YL R+++H DLAARNVL+ N VKI DFG
Sbjct: 406 EYVHE-HKDN-IGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFG 463
Query: 846 LARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN 905
LAR + +E+ + +P+KW+A+EC+ R F+ QSDVWSYG+ +WE+ + PY
Sbjct: 464 LARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDG 523
Query: 906 ISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNER 965
I ++ L G RL +PP +Y VM++CW +RP F EL D +R
Sbjct: 524 IPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQR 583
Score = 41.5 bits (93), Expect = 0.017
Identities = 34/110 (30%), Positives = 51/110 (46%), Gaps = 12/110 (10%)
Query: 613 KQLGAGAFGVVYKAEARGIINAE---VTTPVAVKMVKRTADNMYIKALASELKIMVHLGK 669
K LG+GAFG VYK GI E V PVA+K++ T E IM +
Sbjct: 322 KVLGSGAFGTVYK----GIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASM-D 376
Query: 670 HVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFIDQLTDN 719
H ++V LLG C + ++ + +G + Y+ +H++ QL N
Sbjct: 377 HPHLVRLLGVCLSPTIQ----LVTQLMPHGCLLEYVHEHKDNIGSQLLLN 422
>X00588-1|CAA25240.1| 1210|Homo sapiens epidermal growth factor
receptor protein.
Length = 1210
Score = 153 bits (372), Expect = 3e-36
Identities = 83/238 (34%), Positives = 132/238 (55%), Gaps = 7/238 (2%)
Query: 786 DYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFG 845
DY+ E H+ + S +LL W QIA+GM YL +R+++H DLAARNVL+ VKI DFG
Sbjct: 800 DYVRE-HKDN-IGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFG 857
Query: 846 LARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN 905
LA+ + E+ E +P+KW+A+E ++ RI++ QSDVWSYG+ +WE+ + PY
Sbjct: 858 LAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDG 917
Query: 906 ISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNER 965
I +++ L G RL +PP +Y +M++CW +RP F EL D +
Sbjct: 918 IPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQ- 976
Query: 966 NRYVDLNAPYNEMNAELMTGED-YLAMVCAPDYNNIVTPSPNYVNMAKSFFPATPTPK 1022
RY+ + M+ T + Y A++ D +++V + Y+ + FF + T +
Sbjct: 977 -RYLVIQGD-ERMHLPSPTDSNFYRALMDEEDMDDVV-DADEYLIPQQGFFSSPSTSR 1031
Score = 39.1 bits (87), Expect = 0.090
Identities = 28/99 (28%), Positives = 49/99 (49%), Gaps = 8/99 (8%)
Query: 613 KQLGAGAFGVVYKAEARGIINAE-VTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHV 671
K LG+GAFG VYK I E V PVA+K ++ K + E +M + +
Sbjct: 716 KVLGSGAFGTVYK--GLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASV-DNP 772
Query: 672 NIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHRE 710
++ LLG C + +I + +G + +Y+++H++
Sbjct: 773 HVCRLLGICLTSTVQ----LITQLMPFGCLLDYVREHKD 807
>L36162-1|AAA35487.1| 160|Homo sapiens receptor tyrosine kinase
protein.
Length = 160
Score = 153 bits (372), Expect = 3e-36
Identities = 73/158 (46%), Positives = 105/158 (66%), Gaps = 3/158 (1%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
LT LL +A+Q+A+GME+L + +H DLAARNVL+ VVKICDFGLAR + ++ Y
Sbjct: 1 LTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNY 60
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTD--LLRW 914
+ N+ LPVKW+A E + + I++ +SDVWSYGI+LWE+FSL PYP I P D +
Sbjct: 61 VVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGI-PVDANFYKL 119
Query: 915 LSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTEL 952
+ +G ++++P +A + +Y +M CW RPSF L
Sbjct: 120 IQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 157
>BC094761-1|AAH94761.1| 1091|Homo sapiens EGFR protein protein.
Length = 1091
Score = 153 bits (372), Expect = 3e-36
Identities = 83/238 (34%), Positives = 132/238 (55%), Gaps = 7/238 (2%)
Query: 786 DYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFG 845
DY+ E H+ + S +LL W QIA+GM YL +R+++H DLAARNVL+ VKI DFG
Sbjct: 755 DYVRE-HKDN-IGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFG 812
Query: 846 LARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN 905
LA+ + E+ E +P+KW+A+E ++ RI++ QSDVWSYG+ +WE+ + PY
Sbjct: 813 LAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDG 872
Query: 906 ISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNER 965
I +++ L G RL +PP +Y +M++CW +RP F EL D +
Sbjct: 873 IPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQ- 931
Query: 966 NRYVDLNAPYNEMNAELMTGED-YLAMVCAPDYNNIVTPSPNYVNMAKSFFPATPTPK 1022
RY+ + M+ T + Y A++ D +++V + Y+ + FF + T +
Sbjct: 932 -RYLVIQGD-ERMHLPSPTDSNFYRALMDEEDMDDVV-DADEYLIPQQGFFSSPSTSR 986
Score = 39.1 bits (87), Expect = 0.090
Identities = 28/99 (28%), Positives = 49/99 (49%), Gaps = 8/99 (8%)
Query: 613 KQLGAGAFGVVYKAEARGIINAE-VTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHV 671
K LG+GAFG VYK I E V PVA+K ++ K + E +M + +
Sbjct: 671 KVLGSGAFGTVYK--GLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASV-DNP 727
Query: 672 NIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHRE 710
++ LLG C + +I + +G + +Y+++H++
Sbjct: 728 HVCRLLGICLTSTVQ----LITQLMPFGCLLDYVREHKD 762
>AY588246-1|AAS83109.1| 1210|Homo sapiens epidermal growth factor
receptor (erythroblastic leukemia viral (v-erb-b) oncog
protein.
Length = 1210
Score = 153 bits (372), Expect = 3e-36
Identities = 83/238 (34%), Positives = 132/238 (55%), Gaps = 7/238 (2%)
Query: 786 DYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFG 845
DY+ E H+ + S +LL W QIA+GM YL +R+++H DLAARNVL+ VKI DFG
Sbjct: 800 DYVRE-HKDN-IGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFG 857
Query: 846 LARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN 905
LA+ + E+ E +P+KW+A+E ++ RI++ QSDVWSYG+ +WE+ + PY
Sbjct: 858 LAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDG 917
Query: 906 ISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNER 965
I +++ L G RL +PP +Y +M++CW +RP F EL D +
Sbjct: 918 IPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQ- 976
Query: 966 NRYVDLNAPYNEMNAELMTGED-YLAMVCAPDYNNIVTPSPNYVNMAKSFFPATPTPK 1022
RY+ + M+ T + Y A++ D +++V + Y+ + FF + T +
Sbjct: 977 -RYLVIQGD-ERMHLPSPTDSNFYRALMDEEDMDDVV-DADEYLIPQQGFFSSPSTSR 1031
Score = 39.1 bits (87), Expect = 0.090
Identities = 28/99 (28%), Positives = 49/99 (49%), Gaps = 8/99 (8%)
Query: 613 KQLGAGAFGVVYKAEARGIINAE-VTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHV 671
K LG+GAFG VYK I E V PVA+K ++ K + E +M + +
Sbjct: 716 KVLGSGAFGTVYK--GLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASV-DNP 772
Query: 672 NIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHRE 710
++ LLG C + +I + +G + +Y+++H++
Sbjct: 773 HVCRLLGICLTSTVQ----LITQLMPFGCLLDYVREHKD 807
>AY550966-1|AAT52212.1| 1210|Homo sapiens cell growth inhibiting
protein 40 protein.
Length = 1210
Score = 153 bits (372), Expect = 3e-36
Identities = 83/238 (34%), Positives = 132/238 (55%), Gaps = 7/238 (2%)
Query: 786 DYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFG 845
DY+ E H+ + S +LL W QIA+GM YL +R+++H DLAARNVL+ VKI DFG
Sbjct: 800 DYVRE-HKDN-IGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFG 857
Query: 846 LARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN 905
LA+ + E+ E +P+KW+A+E ++ RI++ QSDVWSYG+ +WE+ + PY
Sbjct: 858 LAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDG 917
Query: 906 ISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNER 965
I +++ L G RL +PP +Y +M++CW +RP F EL D +
Sbjct: 918 IPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQ- 976
Query: 966 NRYVDLNAPYNEMNAELMTGED-YLAMVCAPDYNNIVTPSPNYVNMAKSFFPATPTPK 1022
RY+ + M+ T + Y A++ D +++V + Y+ + FF + T +
Sbjct: 977 -RYLVIQGD-ERMHLPSPTDSNFYRALMDEEDMDDVV-DADEYLIPQQGFFSSPSTSR 1031
Score = 39.1 bits (87), Expect = 0.090
Identities = 28/99 (28%), Positives = 49/99 (49%), Gaps = 8/99 (8%)
Query: 613 KQLGAGAFGVVYKAEARGIINAE-VTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHV 671
K LG+GAFG VYK I E V PVA+K ++ K + E +M + +
Sbjct: 716 KVLGSGAFGTVYK--GLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASV-DNP 772
Query: 672 NIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHRE 710
++ LLG C + +I + +G + +Y+++H++
Sbjct: 773 HVCRLLGICLTSTVQ----LITQLMPFGCLLDYVREHKD 807
>AF288738-1|AAG35789.1| 1210|Homo sapiens p170 epidermal growth factor
receptor protein.
Length = 1210
Score = 153 bits (372), Expect = 3e-36
Identities = 83/238 (34%), Positives = 132/238 (55%), Gaps = 7/238 (2%)
Query: 786 DYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFG 845
DY+ E H+ + S +LL W QIA+GM YL +R+++H DLAARNVL+ VKI DFG
Sbjct: 800 DYVRE-HKDN-IGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFG 857
Query: 846 LARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN 905
LA+ + E+ E +P+KW+A+E ++ RI++ QSDVWSYG+ +WE+ + PY
Sbjct: 858 LAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDG 917
Query: 906 ISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNER 965
I +++ L G RL +PP +Y +M++CW +RP F EL D +
Sbjct: 918 IPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQ- 976
Query: 966 NRYVDLNAPYNEMNAELMTGED-YLAMVCAPDYNNIVTPSPNYVNMAKSFFPATPTPK 1022
RY+ + M+ T + Y A++ D +++V + Y+ + FF + T +
Sbjct: 977 -RYLVIQGD-ERMHLPSPTDSNFYRALMDEEDMDDVV-DADEYLIPQQGFFSSPSTSR 1031
Score = 39.1 bits (87), Expect = 0.090
Identities = 28/99 (28%), Positives = 49/99 (49%), Gaps = 8/99 (8%)
Query: 613 KQLGAGAFGVVYKAEARGIINAE-VTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHV 671
K LG+GAFG VYK I E V PVA+K ++ K + E +M + +
Sbjct: 716 KVLGSGAFGTVYK--GLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASV-DNP 772
Query: 672 NIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHRE 710
++ LLG C + +I + +G + +Y+++H++
Sbjct: 773 HVCRLLGICLTSTVQ----LITQLMPFGCLLDYVREHKD 807
>AB209442-1|BAD92679.1| 1081|Homo sapiens epidermal growth factor
receptor isoform a variant protein.
Length = 1081
Score = 153 bits (372), Expect = 3e-36
Identities = 83/238 (34%), Positives = 132/238 (55%), Gaps = 7/238 (2%)
Query: 786 DYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFG 845
DY+ E H+ + S +LL W QIA+GM YL +R+++H DLAARNVL+ VKI DFG
Sbjct: 671 DYVRE-HKDN-IGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFG 728
Query: 846 LARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN 905
LA+ + E+ E +P+KW+A+E ++ RI++ QSDVWSYG+ +WE+ + PY
Sbjct: 729 LAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDG 788
Query: 906 ISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNER 965
I +++ L G RL +PP +Y +M++CW +RP F EL D +
Sbjct: 789 IPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQ- 847
Query: 966 NRYVDLNAPYNEMNAELMTGED-YLAMVCAPDYNNIVTPSPNYVNMAKSFFPATPTPK 1022
RY+ + M+ T + Y A++ D +++V + Y+ + FF + T +
Sbjct: 848 -RYLVIQGD-ERMHLPSPTDSNFYRALMDEEDMDDVV-DADEYLIPQQGFFSSPSTSR 902
Score = 39.1 bits (87), Expect = 0.090
Identities = 28/99 (28%), Positives = 49/99 (49%), Gaps = 8/99 (8%)
Query: 613 KQLGAGAFGVVYKAEARGIINAE-VTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHV 671
K LG+GAFG VYK I E V PVA+K ++ K + E +M + +
Sbjct: 587 KVLGSGAFGTVYK--GLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASV-DNP 643
Query: 672 NIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHRE 710
++ LLG C + +I + +G + +Y+++H++
Sbjct: 644 HVCRLLGICLTSTVQ----LITQLMPFGCLLDYVREHKD 678
>X60957-1|CAA43290.1| 1138|Homo sapiens receptor tyrosine kinase
protein.
Length = 1138
Score = 153 bits (371), Expect = 4e-36
Identities = 75/176 (42%), Positives = 111/176 (63%), Gaps = 5/176 (2%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
L+S LL +A A GM+YL+ ++ +H DLAARNVL+ ++ KI DFGL+R E Y
Sbjct: 951 LSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRG---EEVY 1007
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
KK LPV+W+AIE + +++T+SDVWS+G++LWE+ SL TPY ++ +L L
Sbjct: 1008 VKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLP 1067
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLN 972
G R+E+P DD +Y +M +CW +P RP F ++ LG LE R YV+++
Sbjct: 1068 QGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLE--ARKAYVNMS 1121
Score = 64.5 bits (150), Expect = 2e-09
Identities = 37/108 (34%), Positives = 58/108 (53%), Gaps = 6/108 (5%)
Query: 607 EKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVH 666
E +TF +G G FG V +A + + A+KM+K A + A EL+++
Sbjct: 837 EDITFEDLIGEGNFGQVIRAMIK---KDGLKMNAAIKMLKEYASENDHRDFAGELEVLCK 893
Query: 667 LGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFID 714
LG H NI+NLLGAC + L + +EY YGN+ ++++K R + D
Sbjct: 894 LGHHPNIINLLGACKN---RGYLYIAIEYAPYGNLLDFLRKSRVLETD 938
>BC038239-1|AAH38239.1| 1138|Homo sapiens tyrosine kinase with
immunoglobulin-like and EGF-like domains 1 protein.
Length = 1138
Score = 153 bits (371), Expect = 4e-36
Identities = 75/176 (42%), Positives = 111/176 (63%), Gaps = 5/176 (2%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
L+S LL +A A GM+YL+ ++ +H DLAARNVL+ ++ KI DFGL+R E Y
Sbjct: 951 LSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRG---EEVY 1007
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
KK LPV+W+AIE + +++T+SDVWS+G++LWE+ SL TPY ++ +L L
Sbjct: 1008 VKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLP 1067
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLN 972
G R+E+P DD +Y +M +CW +P RP F ++ LG LE R YV+++
Sbjct: 1068 QGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLE--ARKAYVNMS 1121
Score = 64.5 bits (150), Expect = 2e-09
Identities = 37/108 (34%), Positives = 58/108 (53%), Gaps = 6/108 (5%)
Query: 607 EKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVH 666
E +TF +G G FG V +A + + A+KM+K A + A EL+++
Sbjct: 837 EDITFEDLIGEGNFGQVIRAMIK---KDGLKMNAAIKMLKEYASENDHRDFAGELEVLCK 893
Query: 667 LGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFID 714
LG H NI+NLLGAC + L + +EY YGN+ ++++K R + D
Sbjct: 894 LGHHPNIINLLGACKN---RGYLYIAIEYAPYGNLLDFLRKSRVLETD 938
>AL139289-10|CAI23385.1| 1138|Homo sapiens tyrosine kinase with
immunoglobulin-like and EGF-like domains 1 protein.
Length = 1138
Score = 153 bits (371), Expect = 4e-36
Identities = 75/176 (42%), Positives = 111/176 (63%), Gaps = 5/176 (2%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
L+S LL +A A GM+YL+ ++ +H DLAARNVL+ ++ KI DFGL+R E Y
Sbjct: 951 LSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRG---EEVY 1007
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
KK LPV+W+AIE + +++T+SDVWS+G++LWE+ SL TPY ++ +L L
Sbjct: 1008 VKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLP 1067
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLN 972
G R+E+P DD +Y +M +CW +P RP F ++ LG LE R YV+++
Sbjct: 1068 QGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLE--ARKAYVNMS 1121
Score = 64.5 bits (150), Expect = 2e-09
Identities = 37/108 (34%), Positives = 58/108 (53%), Gaps = 6/108 (5%)
Query: 607 EKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVH 666
E +TF +G G FG V +A + + A+KM+K A + A EL+++
Sbjct: 837 EDITFEDLIGEGNFGQVIRAMIK---KDGLKMNAAIKMLKEYASENDHRDFAGELEVLCK 893
Query: 667 LGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFID 714
LG H NI+NLLGAC + L + +EY YGN+ ++++K R + D
Sbjct: 894 LGHHPNIINLLGACKN---RGYLYIAIEYAPYGNLLDFLRKSRVLETD 938
>AL139289-9|CAI23386.1| 541|Homo sapiens tyrosine kinase with
immunoglobulin-like and EGF-like domains 1 protein.
Length = 541
Score = 153 bits (371), Expect = 4e-36
Identities = 75/176 (42%), Positives = 111/176 (63%), Gaps = 5/176 (2%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
L+S LL +A A GM+YL+ ++ +H DLAARNVL+ ++ KI DFGL+R E Y
Sbjct: 354 LSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRG---EEVY 410
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
KK LPV+W+AIE + +++T+SDVWS+G++LWE+ SL TPY ++ +L L
Sbjct: 411 VKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLP 470
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLN 972
G R+E+P DD +Y +M +CW +P RP F ++ LG LE R YV+++
Sbjct: 471 QGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLE--ARKAYVNMS 524
Score = 64.5 bits (150), Expect = 2e-09
Identities = 37/108 (34%), Positives = 58/108 (53%), Gaps = 6/108 (5%)
Query: 607 EKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVH 666
E +TF +G G FG V +A + + A+KM+K A + A EL+++
Sbjct: 240 EDITFEDLIGEGNFGQVIRAMIK---KDGLKMNAAIKMLKEYASENDHRDFAGELEVLCK 296
Query: 667 LGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFID 714
LG H NI+NLLGAC + L + +EY YGN+ ++++K R + D
Sbjct: 297 LGHHPNIINLLGACKN---RGYLYIAIEYAPYGNLLDFLRKSRVLETD 341
>AF217976-1|AAG17219.1| 421|Homo sapiens unknown protein.
Length = 421
Score = 153 bits (371), Expect = 4e-36
Identities = 75/176 (42%), Positives = 111/176 (63%), Gaps = 5/176 (2%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
L+S LL +A A GM+YL+ ++ +H DLAARNVL+ ++ KI DFGL+R E Y
Sbjct: 234 LSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRG---EEVY 290
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
KK LPV+W+AIE + +++T+SDVWS+G++LWE+ SL TPY ++ +L L
Sbjct: 291 VKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLP 350
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLN 972
G R+E+P DD +Y +M +CW +P RP F ++ LG LE R YV+++
Sbjct: 351 QGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLE--ARKAYVNMS 404
Score = 64.5 bits (150), Expect = 2e-09
Identities = 37/108 (34%), Positives = 58/108 (53%), Gaps = 6/108 (5%)
Query: 607 EKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVH 666
E +TF +G G FG V +A + + A+KM+K A + A EL+++
Sbjct: 120 EDITFEDLIGEGNFGQVIRAMIK---KDGLKMNAAIKMLKEYASENDHRDFAGELEVLCK 176
Query: 667 LGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHREVFID 714
LG H NI+NLLGAC + L + +EY YGN+ ++++K R + D
Sbjct: 177 LGHHPNIINLLGACKN---RGYLYIAIEYAPYGNLLDFLRKSRVLETD 221
>Z98880-3|CAI42375.1| 2341|Homo sapiens v-ros UR2 sarcoma virus
oncogene homolog 1 (avian) protein.
Length = 2341
Score = 152 bits (368), Expect = 8e-36
Identities = 74/168 (44%), Positives = 105/168 (62%), Gaps = 5/168 (2%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLA-----DDNVVKICDFGLARSMY 851
LT L+ I++G YL +H DLAARN L++ +VKI DFGLAR +Y
Sbjct: 2045 LTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIY 2104
Query: 852 NNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDL 911
N+ Y+K+ LPV+W+A E ++D IF+TQSDVWS+GI++WE+ +L PYP S D+
Sbjct: 2105 KNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDV 2164
Query: 912 LRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNF 959
L ++ G RLE P D L+N+M +CW Q+P RP+F +Q+ L F
Sbjct: 2165 LNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLF 2212
Score = 53.6 bits (123), Expect = 4e-06
Identities = 40/119 (33%), Positives = 58/119 (48%), Gaps = 9/119 (7%)
Query: 596 LPYDEKFE----FPREKLTFGKQLGAGAFGVVYKAEARGIIN-AEVTTPVAVKMVKRTAD 650
LP E+ E FPREKLT LG+GAFG VY+ A I+ VAVK +K+ +
Sbjct: 1922 LPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGST 1981
Query: 651 NMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ E +M H NI+ LG C + +I+E + G++ Y++K R
Sbjct: 1982 DQEKIEFLKEAHLMSKF-NHPNILKQLGVC---LLNEPQYIILELMEGGDLLTYLRKAR 2036
>Z98880-2|CAI42374.1| 2347|Homo sapiens v-ros UR2 sarcoma virus
oncogene homolog 1 (avian) protein.
Length = 2347
Score = 152 bits (368), Expect = 8e-36
Identities = 74/168 (44%), Positives = 105/168 (62%), Gaps = 5/168 (2%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLA-----DDNVVKICDFGLARSMY 851
LT L+ I++G YL +H DLAARN L++ +VKI DFGLAR +Y
Sbjct: 2051 LTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIY 2110
Query: 852 NNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDL 911
N+ Y+K+ LPV+W+A E ++D IF+TQSDVWS+GI++WE+ +L PYP S D+
Sbjct: 2111 KNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDV 2170
Query: 912 LRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNF 959
L ++ G RLE P D L+N+M +CW Q+P RP+F +Q+ L F
Sbjct: 2171 LNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLF 2218
Score = 53.6 bits (123), Expect = 4e-06
Identities = 40/119 (33%), Positives = 58/119 (48%), Gaps = 9/119 (7%)
Query: 596 LPYDEKFE----FPREKLTFGKQLGAGAFGVVYKAEARGIIN-AEVTTPVAVKMVKRTAD 650
LP E+ E FPREKLT LG+GAFG VY+ A I+ VAVK +K+ +
Sbjct: 1928 LPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGST 1987
Query: 651 NMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ E +M H NI+ LG C + +I+E + G++ Y++K R
Sbjct: 1988 DQEKIEFLKEAHLMSKF-NHPNILKQLGVC---LLNEPQYIILELMEGGDLLTYLRKAR 2042
>M13880-1|AAA36580.1| 494|Homo sapiens protein ( Human mcf3
(rearranged ros1) proto-oncogene mRNA encoding a
transmembrane protein kinase, 3' end. ).
Length = 494
Score = 152 bits (368), Expect = 8e-36
Identities = 74/168 (44%), Positives = 105/168 (62%), Gaps = 5/168 (2%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLA-----DDNVVKICDFGLARSMY 851
LT L+ I++G YL +H DLAARN L++ +VKI DFGLAR +Y
Sbjct: 198 LTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIY 257
Query: 852 NNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDL 911
N+ Y+K+ LPV+W+A E ++D IF+TQSDVWS+GI++WE+ +L PYP S D+
Sbjct: 258 KNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDV 317
Query: 912 LRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNF 959
L ++ G RLE P D L+N+M +CW Q+P RP+F +Q+ L F
Sbjct: 318 LNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLF 365
Score = 53.6 bits (123), Expect = 4e-06
Identities = 40/119 (33%), Positives = 58/119 (48%), Gaps = 9/119 (7%)
Query: 596 LPYDEKFE----FPREKLTFGKQLGAGAFGVVYKAEARGIIN-AEVTTPVAVKMVKRTAD 650
LP E+ E FPREKLT LG+GAFG VY+ A I+ VAVK +K+ +
Sbjct: 75 LPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGST 134
Query: 651 NMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ E +M H NI+ LG C + +I+E + G++ Y++K R
Sbjct: 135 DQEKIEFLKEAHLMSKF-NHPNILKQLGVC---LLNEPQYIILELMEGGDLLTYLRKAR 189
>M13599-1|AAA60277.1| 471|Homo sapiens ROS1 protein.
Length = 471
Score = 152 bits (368), Expect = 8e-36
Identities = 74/168 (44%), Positives = 105/168 (62%), Gaps = 5/168 (2%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLA-----DDNVVKICDFGLARSMY 851
LT L+ I++G YL +H DLAARN L++ +VKI DFGLAR +Y
Sbjct: 262 LTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIY 321
Query: 852 NNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDL 911
N+ Y+K+ LPV+W+A E ++D IF+TQSDVWS+GI++WE+ +L PYP S D+
Sbjct: 322 KNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDV 381
Query: 912 LRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNF 959
L ++ G RLE P D L+N+M +CW Q+P RP+F +Q+ L F
Sbjct: 382 LNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLF 429
Score = 53.6 bits (123), Expect = 4e-06
Identities = 40/119 (33%), Positives = 58/119 (48%), Gaps = 9/119 (7%)
Query: 596 LPYDEKFE----FPREKLTFGKQLGAGAFGVVYKAEARGIIN-AEVTTPVAVKMVKRTAD 650
LP E+ E FPREKLT LG+GAFG VY+ A I+ VAVK +K+ +
Sbjct: 139 LPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGST 198
Query: 651 NMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ E +M H NI+ LG C + +I+E + G++ Y++K R
Sbjct: 199 DQEKIEFLKEAHLMSKF-NHPNILKQLGVC---LLNEPQYIILELMEGGDLLTYLRKAR 253
>AL132671-5|CAI23378.1| 2347|Homo sapiens v-ros UR2 sarcoma virus
oncogene homolog 1 (avian) protein.
Length = 2347
Score = 152 bits (368), Expect = 8e-36
Identities = 74/168 (44%), Positives = 105/168 (62%), Gaps = 5/168 (2%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLA-----DDNVVKICDFGLARSMY 851
LT L+ I++G YL +H DLAARN L++ +VKI DFGLAR +Y
Sbjct: 2051 LTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIY 2110
Query: 852 NNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDL 911
N+ Y+K+ LPV+W+A E ++D IF+TQSDVWS+GI++WE+ +L PYP S D+
Sbjct: 2111 KNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDV 2170
Query: 912 LRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNF 959
L ++ G RLE P D L+N+M +CW Q+P RP+F +Q+ L F
Sbjct: 2171 LNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLF 2218
Score = 53.6 bits (123), Expect = 4e-06
Identities = 40/119 (33%), Positives = 58/119 (48%), Gaps = 9/119 (7%)
Query: 596 LPYDEKFE----FPREKLTFGKQLGAGAFGVVYKAEARGIIN-AEVTTPVAVKMVKRTAD 650
LP E+ E FPREKLT LG+GAFG VY+ A I+ VAVK +K+ +
Sbjct: 1928 LPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGST 1987
Query: 651 NMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ E +M H NI+ LG C + +I+E + G++ Y++K R
Sbjct: 1988 DQEKIEFLKEAHLMSKF-NHPNILKQLGVC---LLNEPQYIILELMEGGDLLTYLRKAR 2042
>AL132671-4|CAI23379.1| 2341|Homo sapiens v-ros UR2 sarcoma virus
oncogene homolog 1 (avian) protein.
Length = 2341
Score = 152 bits (368), Expect = 8e-36
Identities = 74/168 (44%), Positives = 105/168 (62%), Gaps = 5/168 (2%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLA-----DDNVVKICDFGLARSMY 851
LT L+ I++G YL +H DLAARN L++ +VKI DFGLAR +Y
Sbjct: 2045 LTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIY 2104
Query: 852 NNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDL 911
N+ Y+K+ LPV+W+A E ++D IF+TQSDVWS+GI++WE+ +L PYP S D+
Sbjct: 2105 KNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDV 2164
Query: 912 LRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNF 959
L ++ G RLE P D L+N+M +CW Q+P RP+F +Q+ L F
Sbjct: 2165 LNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLF 2212
Score = 53.6 bits (123), Expect = 4e-06
Identities = 40/119 (33%), Positives = 58/119 (48%), Gaps = 9/119 (7%)
Query: 596 LPYDEKFE----FPREKLTFGKQLGAGAFGVVYKAEARGIIN-AEVTTPVAVKMVKRTAD 650
LP E+ E FPREKLT LG+GAFG VY+ A I+ VAVK +K+ +
Sbjct: 1922 LPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGST 1981
Query: 651 NMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ E +M H NI+ LG C + +I+E + G++ Y++K R
Sbjct: 1982 DQEKIEFLKEAHLMSKF-NHPNILKQLGVC---LLNEPQYIILELMEGGDLLTYLRKAR 2036
>X04434-1|CAA28030.1| 1367|Homo sapiens IGF-I receptor protein.
Length = 1367
Score = 151 bits (366), Expect = 1e-35
Identities = 74/184 (40%), Positives = 113/184 (61%), Gaps = 4/184 (2%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
P + ++ A +IA GM YL K +H DLAARN ++A+D VKI DFG+ R +Y +
Sbjct: 1106 PPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDY 1165
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
Y+K LPV+W++ E + D +F+T SDVWS+G+VLWE+ +LA+ PY +S +LR++
Sbjct: 1166 YRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV 1225
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLNAPY 975
+G L+KP D L+ +M CW P RPSF EI+ + E+ E + +++ Y
Sbjct: 1226 MEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFL---EIISSIKEEMEPG-FREVSFYY 1281
Query: 976 NEMN 979
+E N
Sbjct: 1282 SEEN 1285
Score = 65.3 bits (152), Expect = 1e-09
Identities = 47/159 (29%), Positives = 81/159 (50%), Gaps = 13/159 (8%)
Query: 551 GMVAYLFTWKLKKQRELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLT 610
G+V L+ + K+ G+L + S N + F+ AD+ DE +E REK+T
Sbjct: 950 GLVIMLYVFHRKRNNSRLGNGVL-YASVNPEYFSA-------ADVYVPDE-WEVAREKIT 1000
Query: 611 FGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKH 670
++LG G+FG+VY+ A+G++ E T VA+K V A +E +M H
Sbjct: 1001 MSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCH 1060
Query: 671 VNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
++V LLG ++ + +VI+E G++ +Y++ R
Sbjct: 1061 -HVVRLLGVVSQ---GQPTLVIMELMTRGDLKSYLRSLR 1095
>M34353-1|AAA60278.1| 2347|Homo sapiens ROS1 protein.
Length = 2347
Score = 151 bits (366), Expect = 1e-35
Identities = 74/168 (44%), Positives = 104/168 (61%), Gaps = 5/168 (2%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLA-----DDNVVKICDFGLARSMY 851
LT L+ I++G YL +H DLAARN L++ +VKI DFGLAR +Y
Sbjct: 2051 LTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIY 2110
Query: 852 NNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDL 911
N+ Y+K+ LPV+W+A E ++D IF+TQSDVWS+GI++WE+ +L PYP S D+
Sbjct: 2111 KNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDV 2170
Query: 912 LRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNF 959
L ++ G RLE P D L+N+M +CW Q+P RP+F +Q L F
Sbjct: 2171 LNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQNQLQLF 2218
Score = 53.6 bits (123), Expect = 4e-06
Identities = 40/119 (33%), Positives = 58/119 (48%), Gaps = 9/119 (7%)
Query: 596 LPYDEKFE----FPREKLTFGKQLGAGAFGVVYKAEARGIIN-AEVTTPVAVKMVKRTAD 650
LP E+ E FPREKLT LG+GAFG VY+ A I+ VAVK +K+ +
Sbjct: 1928 LPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGST 1987
Query: 651 NMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ E +M H NI+ LG C + +I+E + G++ Y++K R
Sbjct: 1988 DQEKIEFLKEAHLMSKF-NHPNILKQLGVC---LLNEPQYIILELMEGGDLLTYLRKAR 2042
>BC113612-1|AAI13613.1| 1367|Homo sapiens insulin-like growth factor 1
receptor protein.
Length = 1367
Score = 151 bits (366), Expect = 1e-35
Identities = 74/184 (40%), Positives = 113/184 (61%), Gaps = 4/184 (2%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
P + ++ A +IA GM YL K +H DLAARN ++A+D VKI DFG+ R +Y +
Sbjct: 1106 PPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDY 1165
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
Y+K LPV+W++ E + D +F+T SDVWS+G+VLWE+ +LA+ PY +S +LR++
Sbjct: 1166 YRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV 1225
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLNAPY 975
+G L+KP D L+ +M CW P RPSF EI+ + E+ E + +++ Y
Sbjct: 1226 MEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFL---EIISSIKEEMEPG-FREVSFYY 1281
Query: 976 NEMN 979
+E N
Sbjct: 1282 SEEN 1285
Score = 65.3 bits (152), Expect = 1e-09
Identities = 47/159 (29%), Positives = 81/159 (50%), Gaps = 13/159 (8%)
Query: 551 GMVAYLFTWKLKKQRELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLT 610
G+V L+ + K+ G+L + S N + F+ AD+ DE +E REK+T
Sbjct: 950 GLVIMLYVFHRKRNNSRLGNGVL-YASVNPEYFSA-------ADVYVPDE-WEVAREKIT 1000
Query: 611 FGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKH 670
++LG G+FG+VY+ A+G++ E T VA+K V A +E +M H
Sbjct: 1001 MSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCH 1060
Query: 671 VNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
++V LLG ++ + +VI+E G++ +Y++ R
Sbjct: 1061 -HVVRLLGVVSQ---GQPTLVIMELMTRGDLKSYLRSLR 1095
>BC113610-1|AAI13611.1| 1367|Homo sapiens insulin-like growth factor 1
receptor protein.
Length = 1367
Score = 151 bits (366), Expect = 1e-35
Identities = 74/184 (40%), Positives = 113/184 (61%), Gaps = 4/184 (2%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
P + ++ A +IA GM YL K +H DLAARN ++A+D VKI DFG+ R +Y +
Sbjct: 1106 PPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDY 1165
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
Y+K LPV+W++ E + D +F+T SDVWS+G+VLWE+ +LA+ PY +S +LR++
Sbjct: 1166 YRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV 1225
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLNAPY 975
+G L+KP D L+ +M CW P RPSF EI+ + E+ E + +++ Y
Sbjct: 1226 MEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFL---EIISSIKEEMEPG-FREVSFYY 1281
Query: 976 NEMN 979
+E N
Sbjct: 1282 SEEN 1285
Score = 65.3 bits (152), Expect = 1e-09
Identities = 47/159 (29%), Positives = 81/159 (50%), Gaps = 13/159 (8%)
Query: 551 GMVAYLFTWKLKKQRELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLT 610
G+V L+ + K+ G+L + S N + F+ AD+ DE +E REK+T
Sbjct: 950 GLVIMLYVFHRKRNNSRLGNGVL-YASVNPEYFSA-------ADVYVPDE-WEVAREKIT 1000
Query: 611 FGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKH 670
++LG G+FG+VY+ A+G++ E T VA+K V A +E +M H
Sbjct: 1001 MSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCH 1060
Query: 671 VNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
++V LLG ++ + +VI+E G++ +Y++ R
Sbjct: 1061 -HVVRLLGVVSQ---GQPTLVIMELMTRGDLKSYLRSLR 1095
>AY332722-1|AAP81165.1| 1367|Homo sapiens insulin-like growth factor 1
receptor protein.
Length = 1367
Score = 151 bits (366), Expect = 1e-35
Identities = 74/184 (40%), Positives = 113/184 (61%), Gaps = 4/184 (2%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
P + ++ A +IA GM YL K +H DLAARN ++A+D VKI DFG+ R +Y +
Sbjct: 1106 PPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDY 1165
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
Y+K LPV+W++ E + D +F+T SDVWS+G+VLWE+ +LA+ PY +S +LR++
Sbjct: 1166 YRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV 1225
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLNAPY 975
+G L+KP D L+ +M CW P RPSF EI+ + E+ E + +++ Y
Sbjct: 1226 MEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFL---EIISSIKEEMEPG-FREVSFYY 1281
Query: 976 NEMN 979
+E N
Sbjct: 1282 SEEN 1285
Score = 65.3 bits (152), Expect = 1e-09
Identities = 47/159 (29%), Positives = 81/159 (50%), Gaps = 13/159 (8%)
Query: 551 GMVAYLFTWKLKKQRELTKAGLLNFKSGNKKSFNPNLGIDEQADLLPYDEKFEFPREKLT 610
G+V L+ + K+ G+L + S N + F+ AD+ DE +E REK+T
Sbjct: 950 GLVIMLYVFHRKRNNSRLGNGVL-YASVNPEYFSA-------ADVYVPDE-WEVAREKIT 1000
Query: 611 FGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMVHLGKH 670
++LG G+FG+VY+ A+G++ E T VA+K V A +E +M H
Sbjct: 1001 MSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCH 1060
Query: 671 VNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
++V LLG ++ + +VI+E G++ +Y++ R
Sbjct: 1061 -HVVRLLGVVSQ---GQPTLVIMELMTRGDLKSYLRSLR 1095
>X02160-1|CAA26096.1| 1370|Homo sapiens protein ( Human mRNA for
insulin receptor precursor. ).
Length = 1370
Score = 150 bits (364), Expect = 2e-35
Identities = 68/161 (42%), Positives = 103/161 (63%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
P T ++ A +IA GM YL +K +H DLAARN ++A D VKI DFG+ R +Y +
Sbjct: 1118 PPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDY 1177
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
Y+K LPV+W+A E + D +F+T SD+WS+G+VLWE+ SLA+ PY +S +L+++
Sbjct: 1178 YRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFV 1237
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEIL 956
DG L++P +R+ ++M CW P RP+F E+ +L
Sbjct: 1238 MDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIVNLL 1278
Score = 64.1 bits (149), Expect = 3e-09
Identities = 37/110 (33%), Positives = 62/110 (56%), Gaps = 4/110 (3%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+++E REK+T ++LG G+FG+VY+ AR II E T VAVK V +A +
Sbjct: 1002 DEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLN 1061
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
E +M H ++V LLG +K + +V++E +G++ +Y++ R
Sbjct: 1062 EASVMKGFTCH-HVVRLLGVVSK---GQPTLVVMELMAHGDLKSYLRSLR 1107
>U02566-1|AAA17407.1| 723|Homo sapiens receptor tyrosine kinase
protein.
Length = 723
Score = 150 bits (364), Expect = 2e-35
Identities = 67/150 (44%), Positives = 102/150 (68%), Gaps = 5/150 (3%)
Query: 812 GMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAI 871
GMEYL++R +H DLAARN +LA+D V + DFGL+R +Y+ + Y++ S LPVKWLA+
Sbjct: 456 GMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLAL 515
Query: 872 ECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRL 931
E + D +++ QSDVW++G+ +WE+ + +TPY I ++ +L GN L++PP + +
Sbjct: 516 ESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGN-LKQPPECMEDV 574
Query: 932 YNVMLRCWHQKPTARPSFT----ELQEILG 957
Y++M +CW P RPSFT EL+ ILG
Sbjct: 575 YDLMYQCWSADPKQRPSFTCLRMELENILG 604
Score = 41.9 bits (94), Expect = 0.013
Identities = 37/128 (28%), Positives = 62/128 (48%), Gaps = 9/128 (7%)
Query: 586 NLGIDEQADLLPYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMV 645
+LGI ++ L E P ++ T G+ LG G FG V +A+ + + V VAVKM+
Sbjct: 312 SLGISDE--LKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFV--KVAVKML 367
Query: 646 KR-TADNMYIKALASELKIMVHLGKHVNIVNLLGACTKHIAKREL---IVIVEYCKYGNI 701
K + I+ E M H ++ L+G + AK L +VI+ + K+G++
Sbjct: 368 KADIIASSDIEEFLREAACMKEF-DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDL 426
Query: 702 HNYMQKHR 709
H ++ R
Sbjct: 427 HAFLLASR 434
>M32972-1|AAA59452.1| 1382|Homo sapiens insulin receptor protein.
Length = 1382
Score = 150 bits (363), Expect = 3e-35
Identities = 68/161 (42%), Positives = 103/161 (63%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
P T ++ A +IA GM YL +K +H DLAARN ++A D VKI DFG+ R +Y +
Sbjct: 1130 PPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDY 1189
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
Y+K LPV+W+A E + D +F+T SD+WS+G+VLWE+ SLA+ PY +S +L+++
Sbjct: 1190 YRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFV 1249
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEIL 956
DG L++P +R+ ++M CW P RP+F E+ +L
Sbjct: 1250 MDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL 1290
Score = 64.1 bits (149), Expect = 3e-09
Identities = 37/110 (33%), Positives = 62/110 (56%), Gaps = 4/110 (3%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+++E REK+T ++LG G+FG+VY+ AR II E T VAVK V +A +
Sbjct: 1014 DEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLN 1073
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
E +M H ++V LLG +K + +V++E +G++ +Y++ R
Sbjct: 1074 EASVMKGFTCH-HVVRLLGVVSK---GQPTLVVMELMAHGDLKSYLRSLR 1119
>M10051-1|AAA59174.1| 1382|Homo sapiens INSR protein.
Length = 1382
Score = 150 bits (363), Expect = 3e-35
Identities = 68/161 (42%), Positives = 103/161 (63%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
P T ++ A +IA GM YL +K +H DLAARN ++A D VKI DFG+ R +Y +
Sbjct: 1130 PPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDY 1189
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
Y+K LPV+W+A E + D +F+T SD+WS+G+VLWE+ SLA+ PY +S +L+++
Sbjct: 1190 YRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFV 1249
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEIL 956
DG L++P +R+ ++M CW P RP+F E+ +L
Sbjct: 1250 MDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL 1290
Score = 64.1 bits (149), Expect = 3e-09
Identities = 37/110 (33%), Positives = 62/110 (56%), Gaps = 4/110 (3%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+++E REK+T ++LG G+FG+VY+ AR II E T VAVK V +A +
Sbjct: 1014 DEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLN 1073
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
E +M H ++V LLG +K + +V++E +G++ +Y++ R
Sbjct: 1074 EASVMKGFTCH-HVVRLLGVVSK---GQPTLVVMELMAHGDLKSYLRSLR 1119
>J05046-1|AAC31759.1| 1268|Homo sapiens insulin receptor-related
receptor protein.
Length = 1268
Score = 150 bits (363), Expect = 3e-35
Identities = 73/172 (42%), Positives = 106/172 (61%), Gaps = 1/172 (0%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P+P G ++ A +IA GM YLA K +H DLAARN +++ D VKI DFG+ R +Y
Sbjct: 1056 PQPAL-GEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYET 1114
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
+ Y+K LPV+W+A E + D IF+T SDVWS+G+VLWE+ +LA+ PY +S +L+
Sbjct: 1115 DYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLK 1174
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNER 965
++ DG LE+ +L +M RCW P RPSFT + + + L + R
Sbjct: 1175 FVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQEELRPSFR 1226
Score = 58.8 bits (136), Expect = 1e-07
Identities = 34/110 (30%), Positives = 62/110 (56%), Gaps = 4/110 (3%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+++E PRE+++ ++LG G+FG+VY+ ARG+ E +TPVA+K V A
Sbjct: 941 DEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLK 1000
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
E +M H ++V LLG ++ + +VI+E G++ ++++ R
Sbjct: 1001 EASVMKAFKCH-HVVRLLGVVSQ---GQPTLVIMELMTRGDLKSHLRSLR 1046
>BC117172-1|AAI17173.1| 1370|Homo sapiens insulin receptor protein.
Length = 1370
Score = 150 bits (363), Expect = 3e-35
Identities = 68/161 (42%), Positives = 103/161 (63%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
P T ++ A +IA GM YL +K +H DLAARN ++A D VKI DFG+ R +Y +
Sbjct: 1118 PPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDY 1177
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
Y+K LPV+W+A E + D +F+T SD+WS+G+VLWE+ SLA+ PY +S +L+++
Sbjct: 1178 YRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFV 1237
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEIL 956
DG L++P +R+ ++M CW P RP+F E+ +L
Sbjct: 1238 MDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL 1278
Score = 64.1 bits (149), Expect = 3e-09
Identities = 37/110 (33%), Positives = 62/110 (56%), Gaps = 4/110 (3%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+++E REK+T ++LG G+FG+VY+ AR II E T VAVK V +A +
Sbjct: 1002 DEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLN 1061
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
E +M H ++V LLG +K + +V++E +G++ +Y++ R
Sbjct: 1062 EASVMKGFTCH-HVVRLLGVVSK---GQPTLVVMELMAHGDLKSYLRSLR 1107
>AL158169-3|CAH70009.1| 1297|Homo sapiens insulin receptor-related
receptor protein.
Length = 1297
Score = 150 bits (363), Expect = 3e-35
Identities = 73/172 (42%), Positives = 106/172 (61%), Gaps = 1/172 (0%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P+P G ++ A +IA GM YLA K +H DLAARN +++ D VKI DFG+ R +Y
Sbjct: 1085 PQPAL-GEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYET 1143
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
+ Y+K LPV+W+A E + D IF+T SDVWS+G+VLWE+ +LA+ PY +S +L+
Sbjct: 1144 DYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLK 1203
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNER 965
++ DG LE+ +L +M RCW P RPSFT + + + L + R
Sbjct: 1204 FVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQEELRPSFR 1255
Score = 58.8 bits (136), Expect = 1e-07
Identities = 34/110 (30%), Positives = 62/110 (56%), Gaps = 4/110 (3%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+++E PRE+++ ++LG G+FG+VY+ ARG+ E +TPVA+K V A
Sbjct: 970 DEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLK 1029
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
E +M H ++V LLG ++ + +VI+E G++ ++++ R
Sbjct: 1030 EASVMKAFKCH-HVVRLLGVVSQ---GQPTLVIMELMTRGDLKSHLRSLR 1075
>AB208861-1|BAD92098.1| 833|Homo sapiens insulin receptor variant
protein.
Length = 833
Score = 150 bits (363), Expect = 3e-35
Identities = 68/161 (42%), Positives = 103/161 (63%)
Query: 796 PLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEE 855
P T ++ A +IA GM YL +K +H DLAARN ++A D VKI DFG+ R +Y +
Sbjct: 581 PPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDY 640
Query: 856 YQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWL 915
Y+K LPV+W+A E + D +F+T SD+WS+G+VLWE+ SLA+ PY +S +L+++
Sbjct: 641 YRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFV 700
Query: 916 SDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEIL 956
DG L++P +R+ ++M CW P RP+F E+ +L
Sbjct: 701 MDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL 741
Score = 64.1 bits (149), Expect = 3e-09
Identities = 37/110 (33%), Positives = 62/110 (56%), Gaps = 4/110 (3%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+++E REK+T ++LG G+FG+VY+ AR II E T VAVK V +A +
Sbjct: 465 DEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLN 524
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
E +M H ++V LLG +K + +V++E +G++ +Y++ R
Sbjct: 525 EASVMKGFTCH-HVVRLLGVVSK---GQPTLVVMELMAHGDLKSYLRSLR 570
>X96588-1|CAA65406.1| 577|Homo sapiens receptor tyrosine kinase
protein.
Length = 577
Score = 149 bits (362), Expect = 4e-35
Identities = 69/172 (40%), Positives = 106/172 (61%)
Query: 788 IYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLA 847
+ E + P+ ++ L+ A QIA GM YLA R+V+H DLAARN ++ D VKI D L+
Sbjct: 398 LVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALS 457
Query: 848 RSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS 907
R ++ + + +N PV+W+A+E +V+ FS+ SDVW++G+ LWE+ +L +TPY +I
Sbjct: 458 RDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDID 517
Query: 908 PTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNF 959
P ++ +L DG R+ +P D L+ VM CW P RP F +L + L F
Sbjct: 518 PFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEF 569
>BC021700-1|AAH21700.2| 395|Homo sapiens RYK protein protein.
Length = 395
Score = 149 bits (362), Expect = 4e-35
Identities = 69/172 (40%), Positives = 106/172 (61%)
Query: 788 IYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLA 847
+ E + P+ ++ L+ A QIA GM YLA R+V+H DLAARN ++ D VKI D L+
Sbjct: 216 LVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALS 275
Query: 848 RSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS 907
R ++ + + +N PV+W+A+E +V+ FS+ SDVW++G+ LWE+ +L +TPY +I
Sbjct: 276 RDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDID 335
Query: 908 PTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNF 959
P ++ +L DG R+ +P D L+ VM CW P RP F +L + L F
Sbjct: 336 PFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEF 387
>AB209405-1|BAD92642.1| 232|Homo sapiens RYK receptor-like tyrosine
kinase isoform 1 variant protein.
Length = 232
Score = 149 bits (362), Expect = 4e-35
Identities = 69/172 (40%), Positives = 106/172 (61%)
Query: 788 IYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLA 847
+ E + P+ ++ L+ A QIA GM YLA R+V+H DLAARN ++ D VKI D L+
Sbjct: 53 LVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALS 112
Query: 848 RSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS 907
R ++ + + +N PV+W+A+E +V+ FS+ SDVW++G+ LWE+ +L +TPY +I
Sbjct: 113 RDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDID 172
Query: 908 PTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNF 959
P ++ +L DG R+ +P D L+ VM CW P RP F +L + L F
Sbjct: 173 PFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEF 224
>X69970-1|CAA49591.1| 607|Homo sapiens h-ryk protein.
Length = 607
Score = 147 bits (357), Expect = 2e-34
Identities = 68/172 (39%), Positives = 105/172 (61%)
Query: 788 IYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLA 847
+ E + P+ ++ L+ QIA GM YLA R+V+H DLAARN ++ D VKI D L+
Sbjct: 428 LVEANNPQAISQHDLVHMPIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALS 487
Query: 848 RSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNIS 907
R ++ + + +N PV+W+A+E +V+ FS+ SDVW++G+ LWE+ +L +TPY +I
Sbjct: 488 RDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDID 547
Query: 908 PTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNF 959
P ++ +L DG R+ +P D L+ VM CW P RP F +L + L F
Sbjct: 548 PFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEF 599
>X03363-1|CAA27060.1| 1255|Homo sapiens protein ( Human c-erb-B-2
mRNA. ).
Length = 1255
Score = 146 bits (353), Expect = 5e-34
Identities = 69/169 (40%), Positives = 97/169 (57%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
L S LL W QIA+GM YL + +++H DLAARNVL+ N VKI DFGLAR + +E
Sbjct: 817 LGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETE 876
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
+ +P+KW+A+E ++ R F+ QSDVWSYG+ +WE+ + PY I ++ L
Sbjct: 877 YHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLE 936
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNER 965
G RL +PP +Y +M++CW RP F EL D +R
Sbjct: 937 KGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQR 985
Score = 37.9 bits (84), Expect = 0.21
Identities = 28/98 (28%), Positives = 49/98 (50%), Gaps = 8/98 (8%)
Query: 613 KQLGAGAFGVVYKAEARGIINAE-VTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHV 671
K LG+GAFG VYK I + E V PVA+K+++ K + E +M +G
Sbjct: 724 KVLGSGAFGTVYK--GIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPY 781
Query: 672 NIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ LLG C + ++ + YG + ++++++R
Sbjct: 782 -VSRLLGICLTSTVQ----LVTQLMPYGCLLDHVRENR 814
>M11767-1|AAA35808.1| 295|Homo sapiens protooncogene protein
protein.
Length = 295
Score = 146 bits (353), Expect = 5e-34
Identities = 69/169 (40%), Positives = 97/169 (57%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
L S LL W QIA+GM YL + +++H DLAARNVL+ N VKI DFGLAR + +E
Sbjct: 81 LGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETE 140
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
+ +P+KW+A+E ++ R F+ QSDVWSYG+ +WE+ + PY I ++ L
Sbjct: 141 YHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLE 200
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNER 965
G RL +PP +Y +M++CW RP F EL D +R
Sbjct: 201 KGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQR 249
>M11730-1|AAA75493.1| 1255|Homo sapiens protein ( Human tyrosine
kinase-type receptor (HER2) mRNA, complete cds. ).
Length = 1255
Score = 146 bits (353), Expect = 5e-34
Identities = 69/169 (40%), Positives = 97/169 (57%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
L S LL W QIA+GM YL + +++H DLAARNVL+ N VKI DFGLAR + +E
Sbjct: 817 LGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETE 876
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
+ +P+KW+A+E ++ R F+ QSDVWSYG+ +WE+ + PY I ++ L
Sbjct: 877 YHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLE 936
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNER 965
G RL +PP +Y +M++CW RP F EL D +R
Sbjct: 937 KGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQR 985
Score = 37.9 bits (84), Expect = 0.21
Identities = 28/98 (28%), Positives = 49/98 (50%), Gaps = 8/98 (8%)
Query: 613 KQLGAGAFGVVYKAEARGIINAE-VTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHV 671
K LG+GAFG VYK I + E V PVA+K+++ K + E +M +G
Sbjct: 724 KVLGSGAFGTVYK--GIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPY 781
Query: 672 NIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ LLG C + ++ + YG + ++++++R
Sbjct: 782 -VSRLLGICLTSTVQ----LVTQLMPYGCLLDHVRENR 814
>AY208911-1|AAO18082.1| 1255|Homo sapiens v-erb-b2 erythroblastic
leukemia viral oncogene homolog 2, neuro/glioblastoma d
protein.
Length = 1255
Score = 146 bits (353), Expect = 5e-34
Identities = 69/169 (40%), Positives = 97/169 (57%)
Query: 797 LTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEY 856
L S LL W QIA+GM YL + +++H DLAARNVL+ N VKI DFGLAR + +E
Sbjct: 817 LGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETE 876
Query: 857 QKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLS 916
+ +P+KW+A+E ++ R F+ QSDVWSYG+ +WE+ + PY I ++ L
Sbjct: 877 YHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLE 936
Query: 917 DGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNER 965
G RL +PP +Y +M++CW RP F EL D +R
Sbjct: 937 KGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQR 985
Score = 37.9 bits (84), Expect = 0.21
Identities = 28/98 (28%), Positives = 49/98 (50%), Gaps = 8/98 (8%)
Query: 613 KQLGAGAFGVVYKAEARGIINAE-VTTPVAVKMVKRTADNMYIKALASELKIMVHLGKHV 671
K LG+GAFG VYK I + E V PVA+K+++ K + E +M +G
Sbjct: 724 KVLGSGAFGTVYK--GIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPY 781
Query: 672 NIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKHR 709
+ LLG C + ++ + YG + ++++++R
Sbjct: 782 -VSRLLGICLTSTVQ----LVTQLMPYGCLLDHVRENR 814
>X06704-1|CAA29888.1| 439|Homo sapiens protein ( Human mRNA for
trk-2h oncogene. ).
Length = 439
Score = 142 bits (344), Expect = 7e-33
Identities = 65/159 (40%), Positives = 98/159 (61%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P PL G LL A Q+A GM YLA +H DLA RN L+ VVKI DFG++R +Y+
Sbjct: 262 PGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYST 321
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
+ Y+ + LP++W+ E ++ R F+T+SDVWS+G+VLWE+F+ K P+ +S T+ +
Sbjct: 322 DYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAID 381
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTEL 952
++ G LE+P +Y +M CWH +P R S ++
Sbjct: 382 CITQGRELERPRACPPEVYAIMRGCWHGEPQQRHSIKDV 420
Score = 53.2 bits (122), Expect = 5e-06
Identities = 29/103 (28%), Positives = 57/103 (55%), Gaps = 5/103 (4%)
Query: 606 REKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMV 665
R + +LG GAFG V+ AE ++ + VAVK +K +++ + E +++
Sbjct: 150 RRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESAR-QDFQREAELLT 208
Query: 666 HLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKH 708
L +H +IV G CT+ R L+++ EY ++G+++ +++ H
Sbjct: 209 ML-QHQHIVRFFGVCTE---GRPLLMVFEYMRHGDLNRFLRSH 247
>X58741-1|CAA41565.2| 348|Homo sapiens tyrosine kinase protein.
Length = 348
Score = 142 bits (343), Expect = 9e-33
Identities = 65/163 (39%), Positives = 101/163 (61%), Gaps = 1/163 (0%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ ++ QIA GM ++ R +H DL A N+L++ V KI DFGLAR + +NE Y +E
Sbjct: 180 LIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNE-YTAREG 238
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
+ P+KW A E + F+ +SDVWS+GI+L E+ + + PYP +S +++R L G R+
Sbjct: 239 AKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRM 298
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
+P + LYN+M+RCW +P RP+F +Q +L +F E
Sbjct: 299 PRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATE 341
Score = 42.3 bits (95), Expect = 0.010
Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 13/107 (12%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+ +E PRE L K+LGAG FG V+ A T VAVK +K +M ++A +
Sbjct: 75 DAWEIPRESLKLEKKLGAGQFGEVWMA------TYNKHTKVAVKTMK--PGSMSVEAFLA 126
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
E +M L +H +V L T K + +I E+ G++ ++++
Sbjct: 127 EANVMKTL-QHDKLVKLHAVVT----KEPIYIITEFMAKGSLLDFLK 168
>M16592-1|AAA52644.1| 505|Homo sapiens HCK protein.
Length = 505
Score = 142 bits (343), Expect = 9e-33
Identities = 65/163 (39%), Positives = 101/163 (61%), Gaps = 1/163 (0%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ ++ QIA GM ++ R +H DL A N+L++ V KI DFGLAR + +NE Y +E
Sbjct: 337 LIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNE-YTAREG 395
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
+ P+KW A E + F+ +SDVWS+GI+L E+ + + PYP +S +++R L G R+
Sbjct: 396 AKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRM 455
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
+P + LYN+M+RCW +P RP+F +Q +L +F E
Sbjct: 456 PRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATE 498
Score = 42.3 bits (95), Expect = 0.010
Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 13/107 (12%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+ +E PRE L K+LGAG FG V+ A T VAVK +K +M ++A +
Sbjct: 232 DAWEIPRESLKLEKKLGAGQFGEVWMA------TYNKHTKVAVKTMK--PGSMSVEAFLA 283
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
E +M L +H +V L T K + +I E+ G++ ++++
Sbjct: 284 EANVMKTL-QHDKLVKLHAVVT----KEPIYIITEFMAKGSLLDFLK 325
>M16591-1|AAA52643.1| 505|Homo sapiens HCK protein.
Length = 505
Score = 142 bits (343), Expect = 9e-33
Identities = 65/163 (39%), Positives = 101/163 (61%), Gaps = 1/163 (0%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ ++ QIA GM ++ R +H DL A N+L++ V KI DFGLAR + +NE Y +E
Sbjct: 337 LIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNE-YTAREG 395
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
+ P+KW A E + F+ +SDVWS+GI+L E+ + + PYP +S +++R L G R+
Sbjct: 396 AKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRM 455
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
+P + LYN+M+RCW +P RP+F +Q +L +F E
Sbjct: 456 PRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATE 498
Score = 42.3 bits (95), Expect = 0.010
Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 13/107 (12%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+ +E PRE L K+LGAG FG V+ A T VAVK +K +M ++A +
Sbjct: 232 DAWEIPRESLKLEKKLGAGQFGEVWMA------TYNKHTKVAVKTMK--PGSMSVEAFLA 283
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
E +M L +H +V L T K + +I E+ G++ ++++
Sbjct: 284 EANVMKTL-QHDKLVKLHAVVT----KEPIYIITEFMAKGSLLDFLK 325
>BC114463-1|AAI14464.2| 526|Homo sapiens hemopoietic cell kinase
protein.
Length = 526
Score = 142 bits (343), Expect = 9e-33
Identities = 65/163 (39%), Positives = 101/163 (61%), Gaps = 1/163 (0%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ ++ QIA GM ++ R +H DL A N+L++ V KI DFGLAR + +NE Y +E
Sbjct: 358 LIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNE-YTAREG 416
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
+ P+KW A E + F+ +SDVWS+GI+L E+ + + PYP +S +++R L G R+
Sbjct: 417 AKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRM 476
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
+P + LYN+M+RCW +P RP+F +Q +L +F E
Sbjct: 477 PRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATE 519
Score = 42.3 bits (95), Expect = 0.010
Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 13/107 (12%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+ +E PRE L K+LGAG FG V+ A T VAVK +K +M ++A +
Sbjct: 253 DAWEIPRESLKLEKKLGAGQFGEVWMA------TYNKHTKVAVKTMK--PGSMSVEAFLA 304
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
E +M L +H +V L T K + +I E+ G++ ++++
Sbjct: 305 EANVMKTL-QHDKLVKLHAVVT----KEPIYIITEFMAKGSLLDFLK 346
>BC108931-1|AAI08932.2| 526|Homo sapiens hemopoietic cell kinase
protein.
Length = 526
Score = 142 bits (343), Expect = 9e-33
Identities = 65/163 (39%), Positives = 101/163 (61%), Gaps = 1/163 (0%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ ++ QIA GM ++ R +H DL A N+L++ V KI DFGLAR + +NE Y +E
Sbjct: 358 LIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNE-YTAREG 416
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
+ P+KW A E + F+ +SDVWS+GI+L E+ + + PYP +S +++R L G R+
Sbjct: 417 AKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRM 476
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
+P + LYN+M+RCW +P RP+F +Q +L +F E
Sbjct: 477 PRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATE 519
Score = 42.3 bits (95), Expect = 0.010
Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 13/107 (12%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+ +E PRE L K+LGAG FG V+ A T VAVK +K +M ++A +
Sbjct: 253 DAWEIPRESLKLEKKLGAGQFGEVWMA------TYNKHTKVAVKTMK--PGSMSVEAFLA 304
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
E +M L +H +V L T K + +I E+ G++ ++++
Sbjct: 305 EANVMKTL-QHDKLVKLHAVVT----KEPIYIITEFMAKGSLLDFLK 346
>BC108930-1|AAI08931.2| 526|Homo sapiens hemopoietic cell kinase
protein.
Length = 526
Score = 142 bits (343), Expect = 9e-33
Identities = 65/163 (39%), Positives = 101/163 (61%), Gaps = 1/163 (0%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ ++ QIA GM ++ R +H DL A N+L++ V KI DFGLAR + +NE Y +E
Sbjct: 358 LIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNE-YTAREG 416
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
+ P+KW A E + F+ +SDVWS+GI+L E+ + + PYP +S +++R L G R+
Sbjct: 417 AKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRM 476
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
+P + LYN+M+RCW +P RP+F +Q +L +F E
Sbjct: 477 PRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATE 519
Score = 42.3 bits (95), Expect = 0.010
Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 13/107 (12%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+ +E PRE L K+LGAG FG V+ A T VAVK +K +M ++A +
Sbjct: 253 DAWEIPRESLKLEKKLGAGQFGEVWMA------TYNKHTKVAVKTMK--PGSMSVEAFLA 304
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
E +M L +H +V L T K + +I E+ G++ ++++
Sbjct: 305 EANVMKTL-QHDKLVKLHAVVT----KEPIYIITEFMAKGSLLDFLK 346
>BC094847-1|AAH94847.2| 526|Homo sapiens hemopoietic cell kinase
protein.
Length = 526
Score = 142 bits (343), Expect = 9e-33
Identities = 65/163 (39%), Positives = 101/163 (61%), Gaps = 1/163 (0%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ ++ QIA GM ++ R +H DL A N+L++ V KI DFGLAR + +NE Y +E
Sbjct: 358 LIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNE-YTAREG 416
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
+ P+KW A E + F+ +SDVWS+GI+L E+ + + PYP +S +++R L G R+
Sbjct: 417 AKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRM 476
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
+P + LYN+M+RCW +P RP+F +Q +L +F E
Sbjct: 477 PRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATE 519
Score = 42.3 bits (95), Expect = 0.010
Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 13/107 (12%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+ +E PRE L K+LGAG FG V+ A T VAVK +K +M ++A +
Sbjct: 253 DAWEIPRESLKLEKKLGAGQFGEVWMA------TYNKHTKVAVKTMK--PGSMSVEAFLA 304
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
E +M L +H +V L T K + +I E+ G++ ++++
Sbjct: 305 EANVMKTL-QHDKLVKLHAVVT----KEPIYIITEFMAKGSLLDFLK 346
>BC014435-1|AAH14435.2| 526|Homo sapiens hemopoietic cell kinase
protein.
Length = 526
Score = 142 bits (343), Expect = 9e-33
Identities = 65/163 (39%), Positives = 101/163 (61%), Gaps = 1/163 (0%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ ++ QIA GM ++ R +H DL A N+L++ V KI DFGLAR + +NE Y +E
Sbjct: 358 LIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNE-YTAREG 416
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
+ P+KW A E + F+ +SDVWS+GI+L E+ + + PYP +S +++R L G R+
Sbjct: 417 AKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRM 476
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
+P + LYN+M+RCW +P RP+F +Q +L +F E
Sbjct: 477 PRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATE 519
Score = 42.3 bits (95), Expect = 0.010
Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 13/107 (12%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+ +E PRE L K+LGAG FG V+ A T VAVK +K +M ++A +
Sbjct: 253 DAWEIPRESLKLEKKLGAGQFGEVWMA------TYNKHTKVAVKTMK--PGSMSVEAFLA 304
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
E +M L +H +V L T K + +I E+ G++ ++++
Sbjct: 305 EANVMKTL-QHDKLVKLHAVVT----KEPIYIITEFMAKGSLLDFLK 346
>AL353092-2|CAI19694.1| 505|Homo sapiens hemopoietic cell kinase
protein.
Length = 505
Score = 142 bits (343), Expect = 9e-33
Identities = 65/163 (39%), Positives = 101/163 (61%), Gaps = 1/163 (0%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ ++ QIA GM ++ R +H DL A N+L++ V KI DFGLAR + +NE Y +E
Sbjct: 337 LIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNE-YTAREG 395
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
+ P+KW A E + F+ +SDVWS+GI+L E+ + + PYP +S +++R L G R+
Sbjct: 396 AKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRM 455
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
+P + LYN+M+RCW +P RP+F +Q +L +F E
Sbjct: 456 PRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATE 498
Score = 42.3 bits (95), Expect = 0.010
Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 13/107 (12%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+ +E PRE L K+LGAG FG V+ A T VAVK +K +M ++A +
Sbjct: 232 DAWEIPRESLKLEKKLGAGQFGEVWMA------TYNKHTKVAVKTMK--PGSMSVEAFLA 283
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
E +M L +H +V L T K + +I E+ G++ ++++
Sbjct: 284 EANVMKTL-QHDKLVKLHAVVT----KEPIYIITEFMAKGSLLDFLK 325
>AL353092-1|CAI19695.1| 504|Homo sapiens hemopoietic cell kinase
protein.
Length = 504
Score = 142 bits (343), Expect = 9e-33
Identities = 65/163 (39%), Positives = 101/163 (61%), Gaps = 1/163 (0%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ ++ QIA GM ++ R +H DL A N+L++ V KI DFGLAR + +NE Y +E
Sbjct: 336 LIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNE-YTAREG 394
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
+ P+KW A E + F+ +SDVWS+GI+L E+ + + PYP +S +++R L G R+
Sbjct: 395 AKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRM 454
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
+P + LYN+M+RCW +P RP+F +Q +L +F E
Sbjct: 455 PRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATE 497
Score = 42.3 bits (95), Expect = 0.010
Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 13/107 (12%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+ +E PRE L K+LGAG FG V+ A T VAVK +K +M ++A +
Sbjct: 231 DAWEIPRESLKLEKKLGAGQFGEVWMA------TYNKHTKVAVKTMK--PGSMSVEAFLA 282
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
E +M L +H +V L T K + +I E+ G++ ++++
Sbjct: 283 EANVMKTL-QHDKLVKLHAVVT----KEPIYIITEFMAKGSLLDFLK 324
>AL121829-14|CAC15526.1| 488|Homo sapiens protein ( Human DNA
sequence from clone RP4-697K14 on chromosome 20. ).
Length = 488
Score = 142 bits (343), Expect = 9e-33
Identities = 70/162 (43%), Positives = 99/162 (61%), Gaps = 1/162 (0%)
Query: 795 RPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNE 854
R L LLG+A Q+A GM YL ++V+H DLAARNVL+ D K+ DFGLAR + ++
Sbjct: 320 RALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLAR-LLKDD 378
Query: 855 EYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRW 914
Y +S +PVKW A E R+FS +SDVWS+G++L E+F+ + PY ++ + L+
Sbjct: 379 IYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQ 438
Query: 915 LSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEIL 956
+ G RL +P +Y +ML CW P RPSF L+E L
Sbjct: 439 IMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKL 480
>AL049539-2|CAI22967.1| 504|Homo sapiens hemopoietic cell kinase
protein.
Length = 504
Score = 142 bits (343), Expect = 9e-33
Identities = 65/163 (39%), Positives = 101/163 (61%), Gaps = 1/163 (0%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ ++ QIA GM ++ R +H DL A N+L++ V KI DFGLAR + +NE Y +E
Sbjct: 336 LIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNE-YTAREG 394
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
+ P+KW A E + F+ +SDVWS+GI+L E+ + + PYP +S +++R L G R+
Sbjct: 395 AKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRM 454
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
+P + LYN+M+RCW +P RP+F +Q +L +F E
Sbjct: 455 PRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATE 497
Score = 42.3 bits (95), Expect = 0.010
Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 13/107 (12%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+ +E PRE L K+LGAG FG V+ A T VAVK +K +M ++A +
Sbjct: 231 DAWEIPRESLKLEKKLGAGQFGEVWMA------TYNKHTKVAVKTMK--PGSMSVEAFLA 282
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
E +M L +H +V L T K + +I E+ G++ ++++
Sbjct: 283 EANVMKTL-QHDKLVKLHAVVT----KEPIYIITEFMAKGSLLDFLK 324
>AL049539-1|CAI22966.1| 505|Homo sapiens hemopoietic cell kinase
protein.
Length = 505
Score = 142 bits (343), Expect = 9e-33
Identities = 65/163 (39%), Positives = 101/163 (61%), Gaps = 1/163 (0%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ ++ QIA GM ++ R +H DL A N+L++ V KI DFGLAR + +NE Y +E
Sbjct: 337 LIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNE-YTAREG 395
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
+ P+KW A E + F+ +SDVWS+GI+L E+ + + PYP +S +++R L G R+
Sbjct: 396 AKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRM 455
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
+P + LYN+M+RCW +P RP+F +Q +L +F E
Sbjct: 456 PRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATE 498
Score = 42.3 bits (95), Expect = 0.010
Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 13/107 (12%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+ +E PRE L K+LGAG FG V+ A T VAVK +K +M ++A +
Sbjct: 232 DAWEIPRESLKLEKKLGAGQFGEVWMA------TYNKHTKVAVKTMK--PGSMSVEAFLA 283
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
E +M L +H +V L T K + +I E+ G++ ++++
Sbjct: 284 EANVMKTL-QHDKLVKLHAVVT----KEPIYIITEFMAKGSLLDFLK 325
>AK026432-1|BAB15482.1| 505|Homo sapiens protein ( Homo sapiens
cDNA: FLJ22779 fis, clone KAIA1741. ).
Length = 505
Score = 142 bits (343), Expect = 9e-33
Identities = 65/163 (39%), Positives = 101/163 (61%), Gaps = 1/163 (0%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ ++ QIA GM ++ R +H DL A N+L++ V KI DFGLAR + +NE Y +E
Sbjct: 337 LIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNE-YTAREG 395
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
+ P+KW A E + F+ +SDVWS+GI+L E+ + + PYP +S +++R L G R+
Sbjct: 396 AKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRM 455
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
+P + LYN+M+RCW +P RP+F +Q +L +F E
Sbjct: 456 PRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATE 498
Score = 42.3 bits (95), Expect = 0.010
Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 13/107 (12%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+ +E PRE L K+LGAG FG V+ A T VAVK +K +M ++A +
Sbjct: 232 DAWEIPRESLKLEKKLGAGQFGEVWMA------TYNKHTKVAVKTMK--PGSMSVEAFLA 283
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
E +M L +H +V L T K + +I E+ G++ ++++
Sbjct: 284 EANVMKTL-QHDKLVKLHAVVT----KEPIYIITEFMAKGSLLDFLK 325
>U22322-1|AAC50116.1| 505|Homo sapiens Rak protein.
Length = 505
Score = 141 bits (342), Expect = 1e-32
Identities = 68/169 (40%), Positives = 103/169 (60%), Gaps = 4/169 (2%)
Query: 806 AFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLAR--SMYNNEEYQKKENSP 863
A Q+A GM YL +R +H DLAARNVL+ + N+ K+ DFGLAR + N + Y+ +
Sbjct: 335 AAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIK 394
Query: 864 LPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEK 923
LPVKW A E + FS +SDVWS+GI+L+E+ + K PY ++ +++ L+ RL +
Sbjct: 395 LPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQ 454
Query: 924 PPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLN 972
P + YN+ML CW+ +P RP+F L+ L ++ E + + Y D N
Sbjct: 455 PSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETD--SSYSDAN 501
Score = 46.0 bits (104), Expect = 8e-04
Identities = 33/107 (30%), Positives = 57/107 (53%), Gaps = 12/107 (11%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+++E R + K+LG+G FG V++ G+ N TTPVAVK +K +M
Sbjct: 225 DQWEIDRNSIQLLKRLGSGQFGEVWE----GLWNN--TTPVAVKTLK--PGSMDPNDFLR 276
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
E +IM +L +H ++ L CT + + +I E ++G++ Y+Q
Sbjct: 277 EAQIMKNL-RHPKLIQLYAVCT---LEDPIYIITELMRHGSLQEYLQ 319
>U00803-1|AAA18284.1| 505|Homo sapiens SRC-like tyrosine kinase
protein.
Length = 505
Score = 141 bits (342), Expect = 1e-32
Identities = 68/169 (40%), Positives = 103/169 (60%), Gaps = 4/169 (2%)
Query: 806 AFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLAR--SMYNNEEYQKKENSP 863
A Q+A GM YL +R +H DLAARNVL+ + N+ K+ DFGLAR + N + Y+ +
Sbjct: 335 AAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIK 394
Query: 864 LPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEK 923
LPVKW A E + FS +SDVWS+GI+L+E+ + K PY ++ +++ L+ RL +
Sbjct: 395 LPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQ 454
Query: 924 PPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLN 972
P + YN+ML CW+ +P RP+F L+ L ++ E + + Y D N
Sbjct: 455 PSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETD--SSYSDAN 501
Score = 46.0 bits (104), Expect = 8e-04
Identities = 33/107 (30%), Positives = 57/107 (53%), Gaps = 12/107 (11%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+++E R + K+LG+G FG V++ G+ N TTPVAVK +K +M
Sbjct: 225 DQWEIDRNSIQLLKRLGSGQFGEVWE----GLWNN--TTPVAVKTLK--PGSMDPNDFLR 276
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
E +IM +L +H ++ L CT + + +I E ++G++ Y+Q
Sbjct: 277 EAQIMKNL-RHPKLIQLYAVCT---LEDPIYIITELMRHGSLQEYLQ 319
>M35296-1|AAA35553.1| 1182|Homo sapiens protein ( Human tyrosine
kinase arg gene mRNA. ).
Length = 1182
Score = 141 bits (342), Expect = 1e-32
Identities = 67/178 (37%), Positives = 102/178 (57%), Gaps = 2/178 (1%)
Query: 786 DYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFG 845
DY+ EC++ +T+ LL A QI+ MEYL + +H DLAARN L+ +++VVK+ DFG
Sbjct: 371 DYLRECNREE-VTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFG 429
Query: 846 LARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN 905
L+R M + Y + P+KW A E + FS +SDVW++G++LWE+ + +PYP
Sbjct: 430 LSRLM-TGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPG 488
Query: 906 ISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
I + + L G R+E+P ++Y +M CW P RPSF E + D+
Sbjct: 489 IDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDS 546
Score = 57.2 bits (132), Expect = 3e-07
Identities = 35/111 (31%), Positives = 57/111 (51%), Gaps = 11/111 (9%)
Query: 597 PYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKA 656
P +K+E R +T +LG G +G VY + + + VAVK +K D M ++
Sbjct: 276 PIHDKWEMERTDITMKHKLGGGQYGEVYVG-----VWKKYSLTVAVKTLKE--DTMEVEE 328
Query: 657 LASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQK 707
E +M + KH N+V LLG CT + ++ EY YGN+ +Y+++
Sbjct: 329 FLKEAAVMKEI-KHPNLVQLLGVCT---LEPPFYIVTEYMPYGNLLDYLRE 375
>DQ009672-1|AAY16984.1| 1182|Homo sapiens v-abl Abelson murine
leukemia viral oncogene homolog 2 (arg, Abelson-related
ge protein.
Length = 1182
Score = 141 bits (342), Expect = 1e-32
Identities = 67/178 (37%), Positives = 102/178 (57%), Gaps = 2/178 (1%)
Query: 786 DYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFG 845
DY+ EC++ +T+ LL A QI+ MEYL + +H DLAARN L+ +++VVK+ DFG
Sbjct: 371 DYLRECNREE-VTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFG 429
Query: 846 LARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN 905
L+R M + Y + P+KW A E + FS +SDVW++G++LWE+ + +PYP
Sbjct: 430 LSRLM-TGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPG 488
Query: 906 ISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
I + + L G R+E+P ++Y +M CW P RPSF E + D+
Sbjct: 489 IDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDS 546
Score = 57.2 bits (132), Expect = 3e-07
Identities = 35/111 (31%), Positives = 57/111 (51%), Gaps = 11/111 (9%)
Query: 597 PYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKA 656
P +K+E R +T +LG G +G VY + + + VAVK +K D M ++
Sbjct: 276 PIHDKWEMERTDITMKHKLGGGQYGEVYVG-----VWKKYSLTVAVKTLKE--DTMEVEE 328
Query: 657 LASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQK 707
E +M + KH N+V LLG CT + ++ EY YGN+ +Y+++
Sbjct: 329 FLKEAAVMKEI-KHPNLVQLLGVCT---LEPPFYIVTEYMPYGNLLDYLRE 375
>BX538317-1|CAD98092.1| 1092|Homo sapiens hypothetical protein
protein.
Length = 1092
Score = 141 bits (342), Expect = 1e-32
Identities = 67/178 (37%), Positives = 102/178 (57%), Gaps = 2/178 (1%)
Query: 786 DYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFG 845
DY+ EC++ +T+ LL A QI+ MEYL + +H DLAARN L+ +++VVK+ DFG
Sbjct: 384 DYLRECNREE-VTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFG 442
Query: 846 LARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN 905
L+R M + Y + P+KW A E + FS +SDVW++G++LWE+ + +PYP
Sbjct: 443 LSRLM-TGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPG 501
Query: 906 ISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
I + + L G R+E+P ++Y +M CW P RPSF E + D+
Sbjct: 502 IDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDS 559
Score = 57.2 bits (132), Expect = 3e-07
Identities = 35/111 (31%), Positives = 57/111 (51%), Gaps = 11/111 (9%)
Query: 597 PYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKA 656
P +K+E R +T +LG G +G VY + + + VAVK +K D M ++
Sbjct: 289 PIHDKWEMERTDITMKHKLGGGQYGEVYVG-----VWKKYSLTVAVKTLKE--DTMEVEE 341
Query: 657 LASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQK 707
E +M + KH N+V LLG CT + ++ EY YGN+ +Y+++
Sbjct: 342 FLKEAAVMKEI-KHPNLVQLLGVCT---LEPPFYIVTEYMPYGNLLDYLRE 388
>BC065912-1|AAH65912.1| 1167|Homo sapiens ABL2 protein protein.
Length = 1167
Score = 141 bits (342), Expect = 1e-32
Identities = 67/178 (37%), Positives = 102/178 (57%), Gaps = 2/178 (1%)
Query: 786 DYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFG 845
DY+ EC++ +T+ LL A QI+ MEYL + +H DLAARN L+ +++VVK+ DFG
Sbjct: 356 DYLRECNREE-VTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFG 414
Query: 846 LARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN 905
L+R M + Y + P+KW A E + FS +SDVW++G++LWE+ + +PYP
Sbjct: 415 LSRLM-TGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPG 473
Query: 906 ISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
I + + L G R+E+P ++Y +M CW P RPSF E + D+
Sbjct: 474 IDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDS 531
Score = 57.2 bits (132), Expect = 3e-07
Identities = 35/111 (31%), Positives = 57/111 (51%), Gaps = 11/111 (9%)
Query: 597 PYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKA 656
P +K+E R +T +LG G +G VY + + + VAVK +K D M ++
Sbjct: 261 PIHDKWEMERTDITMKHKLGGGQYGEVYVG-----VWKKYSLTVAVKTLKE--DTMEVEE 313
Query: 657 LASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQK 707
E +M + KH N+V LLG CT + ++ EY YGN+ +Y+++
Sbjct: 314 FLKEAAVMKEI-KHPNLVQLLGVCT---LEPPFYIVTEYMPYGNLLDYLRE 360
>BC012916-1|AAH12916.1| 505|Homo sapiens fyn-related kinase
protein.
Length = 505
Score = 141 bits (342), Expect = 1e-32
Identities = 68/169 (40%), Positives = 103/169 (60%), Gaps = 4/169 (2%)
Query: 806 AFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLAR--SMYNNEEYQKKENSP 863
A Q+A GM YL +R +H DLAARNVL+ + N+ K+ DFGLAR + N + Y+ +
Sbjct: 335 AAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIK 394
Query: 864 LPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEK 923
LPVKW A E + FS +SDVWS+GI+L+E+ + K PY ++ +++ L+ RL +
Sbjct: 395 LPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQ 454
Query: 924 PPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLN 972
P + YN+ML CW+ +P RP+F L+ L ++ E + + Y D N
Sbjct: 455 PSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETD--SSYSDAN 501
Score = 46.0 bits (104), Expect = 8e-04
Identities = 33/107 (30%), Positives = 57/107 (53%), Gaps = 12/107 (11%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+++E R + K+LG+G FG V++ G+ N TTPVAVK +K +M
Sbjct: 225 DQWEIDRNSIQLLKRLGSGQFGEVWE----GLWNN--TTPVAVKTLK--PGSMDPNDFLR 276
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
E +IM +L +H ++ L CT + + +I E ++G++ Y+Q
Sbjct: 277 EAQIMKNL-RHPKLIQLYAVCT---LEDPIYIITELMRHGSLQEYLQ 319
>AL512326-6|CAI13570.1| 1182|Homo sapiens v-abl Abelson murine
leukemia viral oncogene homolog 2 (arg, Abelson-related
ge protein.
Length = 1182
Score = 141 bits (342), Expect = 1e-32
Identities = 67/178 (37%), Positives = 102/178 (57%), Gaps = 2/178 (1%)
Query: 786 DYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFG 845
DY+ EC++ +T+ LL A QI+ MEYL + +H DLAARN L+ +++VVK+ DFG
Sbjct: 371 DYLRECNREE-VTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFG 429
Query: 846 LARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN 905
L+R M + Y + P+KW A E + FS +SDVW++G++LWE+ + +PYP
Sbjct: 430 LSRLM-TGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPG 488
Query: 906 ISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
I + + L G R+E+P ++Y +M CW P RPSF E + D+
Sbjct: 489 IDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDS 546
Score = 57.2 bits (132), Expect = 3e-07
Identities = 35/111 (31%), Positives = 57/111 (51%), Gaps = 11/111 (9%)
Query: 597 PYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKA 656
P +K+E R +T +LG G +G VY + + + VAVK +K D M ++
Sbjct: 276 PIHDKWEMERTDITMKHKLGGGQYGEVYVG-----VWKKYSLTVAVKTLKE--DTMEVEE 328
Query: 657 LASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQK 707
E +M + KH N+V LLG CT + ++ EY YGN+ +Y+++
Sbjct: 329 FLKEAAVMKEI-KHPNLVQLLGVCT---LEPPFYIVTEYMPYGNLLDYLRE 375
>AL512326-2|CAI13566.1| 1064|Homo sapiens v-abl Abelson murine
leukemia viral oncogene homolog 2 (arg, Abelson-related
ge protein.
Length = 1064
Score = 141 bits (342), Expect = 1e-32
Identities = 67/178 (37%), Positives = 102/178 (57%), Gaps = 2/178 (1%)
Query: 786 DYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFG 845
DY+ EC++ +T+ LL A QI+ MEYL + +H DLAARN L+ +++VVK+ DFG
Sbjct: 356 DYLRECNREE-VTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFG 414
Query: 846 LARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN 905
L+R M + Y + P+KW A E + FS +SDVW++G++LWE+ + +PYP
Sbjct: 415 LSRLM-TGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPG 473
Query: 906 ISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
I + + L G R+E+P ++Y +M CW P RPSF E + D+
Sbjct: 474 IDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDS 531
Score = 57.2 bits (132), Expect = 3e-07
Identities = 35/111 (31%), Positives = 57/111 (51%), Gaps = 11/111 (9%)
Query: 597 PYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKA 656
P +K+E R +T +LG G +G VY + + + VAVK +K D M ++
Sbjct: 261 PIHDKWEMERTDITMKHKLGGGQYGEVYVG-----VWKKYSLTVAVKTLKE--DTMEVEE 313
Query: 657 LASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQK 707
E +M + KH N+V LLG CT + ++ EY YGN+ +Y+++
Sbjct: 314 FLKEAAVMKEI-KHPNLVQLLGVCT---LEPPFYIVTEYMPYGNLLDYLRE 360
>AL359179-2|CAI15585.1| 1182|Homo sapiens v-abl Abelson murine
leukemia viral oncogene homolog 2 (arg, Abelson-related
ge protein.
Length = 1182
Score = 141 bits (342), Expect = 1e-32
Identities = 67/178 (37%), Positives = 102/178 (57%), Gaps = 2/178 (1%)
Query: 786 DYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFG 845
DY+ EC++ +T+ LL A QI+ MEYL + +H DLAARN L+ +++VVK+ DFG
Sbjct: 371 DYLRECNREE-VTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFG 429
Query: 846 LARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN 905
L+R M + Y + P+KW A E + FS +SDVW++G++LWE+ + +PYP
Sbjct: 430 LSRLM-TGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPG 488
Query: 906 ISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
I + + L G R+E+P ++Y +M CW P RPSF E + D+
Sbjct: 489 IDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDS 546
Score = 57.2 bits (132), Expect = 3e-07
Identities = 35/111 (31%), Positives = 57/111 (51%), Gaps = 11/111 (9%)
Query: 597 PYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKA 656
P +K+E R +T +LG G +G VY + + + VAVK +K D M ++
Sbjct: 276 PIHDKWEMERTDITMKHKLGGGQYGEVYVG-----VWKKYSLTVAVKTLKE--DTMEVEE 328
Query: 657 LASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQK 707
E +M + KH N+V LLG CT + ++ EY YGN+ +Y+++
Sbjct: 329 FLKEAAVMKEI-KHPNLVQLLGVCT---LEPPFYIVTEYMPYGNLLDYLRE 375
>AL359179-1|CAI15584.1| 1064|Homo sapiens v-abl Abelson murine
leukemia viral oncogene homolog 2 (arg, Abelson-related
ge protein.
Length = 1064
Score = 141 bits (342), Expect = 1e-32
Identities = 67/178 (37%), Positives = 102/178 (57%), Gaps = 2/178 (1%)
Query: 786 DYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFG 845
DY+ EC++ +T+ LL A QI+ MEYL + +H DLAARN L+ +++VVK+ DFG
Sbjct: 356 DYLRECNREE-VTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFG 414
Query: 846 LARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN 905
L+R M + Y + P+KW A E + FS +SDVW++G++LWE+ + +PYP
Sbjct: 415 LSRLM-TGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPG 473
Query: 906 ISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
I + + L G R+E+P ++Y +M CW P RPSF E + D+
Sbjct: 474 IDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDS 531
Score = 57.2 bits (132), Expect = 3e-07
Identities = 35/111 (31%), Positives = 57/111 (51%), Gaps = 11/111 (9%)
Query: 597 PYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKA 656
P +K+E R +T +LG G +G VY + + + VAVK +K D M ++
Sbjct: 261 PIHDKWEMERTDITMKHKLGGGQYGEVYVG-----VWKKYSLTVAVKTLKE--DTMEVEE 313
Query: 657 LASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQK 707
E +M + KH N+V LLG CT + ++ EY YGN+ +Y+++
Sbjct: 314 FLKEAAVMKEI-KHPNLVQLLGVCT---LEPPFYIVTEYMPYGNLLDYLRE 360
>AL357141-2|CAI16469.1| 505|Homo sapiens fyn-related kinase
protein.
Length = 505
Score = 141 bits (342), Expect = 1e-32
Identities = 68/169 (40%), Positives = 103/169 (60%), Gaps = 4/169 (2%)
Query: 806 AFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLAR--SMYNNEEYQKKENSP 863
A Q+A GM YL +R +H DLAARNVL+ + N+ K+ DFGLAR + N + Y+ +
Sbjct: 335 AAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIK 394
Query: 864 LPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEK 923
LPVKW A E + FS +SDVWS+GI+L+E+ + K PY ++ +++ L+ RL +
Sbjct: 395 LPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQ 454
Query: 924 PPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLN 972
P + YN+ML CW+ +P RP+F L+ L ++ E + + Y D N
Sbjct: 455 PSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETD--SSYSDAN 501
Score = 46.0 bits (104), Expect = 8e-04
Identities = 33/107 (30%), Positives = 57/107 (53%), Gaps = 12/107 (11%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+++E R + K+LG+G FG V++ G+ N TTPVAVK +K +M
Sbjct: 225 DQWEIDRNSIQLLKRLGSGQFGEVWE----GLWNN--TTPVAVKTLK--PGSMDPNDFLR 276
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
E +IM +L +H ++ L CT + + +I E ++G++ Y+Q
Sbjct: 277 EAQIMKNL-RHPKLIQLYAVCT---LEDPIYIITELMRHGSLQEYLQ 319
>AL139132-5|CAH70925.1| 1182|Homo sapiens v-abl Abelson murine
leukemia viral oncogene homolog 2 (arg, Abelson-related
ge protein.
Length = 1182
Score = 141 bits (342), Expect = 1e-32
Identities = 67/178 (37%), Positives = 102/178 (57%), Gaps = 2/178 (1%)
Query: 786 DYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFG 845
DY+ EC++ +T+ LL A QI+ MEYL + +H DLAARN L+ +++VVK+ DFG
Sbjct: 371 DYLRECNREE-VTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFG 429
Query: 846 LARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN 905
L+R M + Y + P+KW A E + FS +SDVW++G++LWE+ + +PYP
Sbjct: 430 LSRLM-TGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPG 488
Query: 906 ISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
I + + L G R+E+P ++Y +M CW P RPSF E + D+
Sbjct: 489 IDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDS 546
Score = 57.2 bits (132), Expect = 3e-07
Identities = 35/111 (31%), Positives = 57/111 (51%), Gaps = 11/111 (9%)
Query: 597 PYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKA 656
P +K+E R +T +LG G +G VY + + + VAVK +K D M ++
Sbjct: 276 PIHDKWEMERTDITMKHKLGGGQYGEVYVG-----VWKKYSLTVAVKTLKE--DTMEVEE 328
Query: 657 LASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQK 707
E +M + KH N+V LLG CT + ++ EY YGN+ +Y+++
Sbjct: 329 FLKEAAVMKEI-KHPNLVQLLGVCT---LEPPFYIVTEYMPYGNLLDYLRE 375
>AL139132-1|CAH70921.1| 1064|Homo sapiens v-abl Abelson murine
leukemia viral oncogene homolog 2 (arg, Abelson-related
ge protein.
Length = 1064
Score = 141 bits (342), Expect = 1e-32
Identities = 67/178 (37%), Positives = 102/178 (57%), Gaps = 2/178 (1%)
Query: 786 DYIYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFG 845
DY+ EC++ +T+ LL A QI+ MEYL + +H DLAARN L+ +++VVK+ DFG
Sbjct: 356 DYLRECNREE-VTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFG 414
Query: 846 LARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPN 905
L+R M + Y + P+KW A E + FS +SDVW++G++LWE+ + +PYP
Sbjct: 415 LSRLM-TGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPG 473
Query: 906 ISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDN 963
I + + L G R+E+P ++Y +M CW P RPSF E + D+
Sbjct: 474 IDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDS 531
Score = 57.2 bits (132), Expect = 3e-07
Identities = 35/111 (31%), Positives = 57/111 (51%), Gaps = 11/111 (9%)
Query: 597 PYDEKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKA 656
P +K+E R +T +LG G +G VY + + + VAVK +K D M ++
Sbjct: 261 PIHDKWEMERTDITMKHKLGGGQYGEVYVG-----VWKKYSLTVAVKTLKE--DTMEVEE 313
Query: 657 LASELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQK 707
E +M + KH N+V LLG CT + ++ EY YGN+ +Y+++
Sbjct: 314 FLKEAAVMKEI-KHPNLVQLLGVCT---LEPPFYIVTEYMPYGNLLDYLRE 360
>AL121963-8|CAB87592.2| 505|Homo sapiens fyn-related kinase
protein.
Length = 505
Score = 141 bits (342), Expect = 1e-32
Identities = 68/169 (40%), Positives = 103/169 (60%), Gaps = 4/169 (2%)
Query: 806 AFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLAR--SMYNNEEYQKKENSP 863
A Q+A GM YL +R +H DLAARNVL+ + N+ K+ DFGLAR + N + Y+ +
Sbjct: 335 AAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIK 394
Query: 864 LPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRLEK 923
LPVKW A E + FS +SDVWS+GI+L+E+ + K PY ++ +++ L+ RL +
Sbjct: 395 LPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQ 454
Query: 924 PPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNERNRYVDLN 972
P + YN+ML CW+ +P RP+F L+ L ++ E + + Y D N
Sbjct: 455 PSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETD--SSYSDAN 501
Score = 46.0 bits (104), Expect = 8e-04
Identities = 33/107 (30%), Positives = 57/107 (53%), Gaps = 12/107 (11%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+++E R + K+LG+G FG V++ G+ N TTPVAVK +K +M
Sbjct: 225 DQWEIDRNSIQLLKRLGSGQFGEVWE----GLWNN--TTPVAVKTLK--PGSMDPNDFLR 276
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
E +IM +L +H ++ L CT + + +I E ++G++ Y+Q
Sbjct: 277 EAQIMKNL-RHPKLIQLYAVCT---LEDPIYIITELMRHGSLQEYLQ 319
>X52213-1|CAA36460.1| 464|Homo sapiens ltk protein.
Length = 464
Score = 140 bits (340), Expect = 2e-32
Identities = 67/172 (38%), Positives = 100/172 (58%), Gaps = 2/172 (1%)
Query: 793 QPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLL--ADDNVVKICDFGLARSM 850
QP PL LL A IA+G YL +H D+AARN LL V KI DFG+AR +
Sbjct: 212 QPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLMRGPSRVAKIGDFGMARDI 271
Query: 851 YNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTD 910
Y Y++ + + LPVKW+ E ++ IF++++D WS+G++LWE+FSL PYP + +
Sbjct: 272 YRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQE 331
Query: 911 LLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLED 962
+L ++ G R++ P +Y +M +CW +P RPSF + E L +D
Sbjct: 332 VLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQD 383
>BC113854-1|AAI13855.2| 504|Homo sapiens HCK protein protein.
Length = 504
Score = 140 bits (340), Expect = 2e-32
Identities = 65/163 (39%), Positives = 100/163 (61%), Gaps = 1/163 (0%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
L+ ++ QIA GM ++ R H DL A N+L++ V KI DFGLAR + +NE Y +E
Sbjct: 336 LIDFSAQIAEGMAFIEQRNYTHRDLRAANILVSASLVCKIADFGLARVIEDNE-YTAREG 394
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
+ P+KW A E + F+ +SDVWS+GI+L E+ + + PYP +S +++R L G R+
Sbjct: 395 AKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRM 454
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLEDNE 964
+P + LYN+M+RCW +P RP+F +Q +L +F E
Sbjct: 455 PRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATE 497
Score = 42.3 bits (95), Expect = 0.010
Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 13/107 (12%)
Query: 600 EKFEFPREKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALAS 659
+ +E PRE L K+LGAG FG V+ A T VAVK +K +M ++A +
Sbjct: 231 DAWEIPRESLKLEKKLGAGQFGEVWMA------TYNKHTKVAVKTMK--PGSMSVEAFLA 282
Query: 660 ELKIMVHLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQ 706
E +M L +H +V L T K + +I E+ G++ ++++
Sbjct: 283 EANVMKTL-QHDKLVKLHAVVT----KEPIYIITEFMAKGSLLDFLK 324
>X85960-1|CAA59936.1| 591|Homo sapiens p68 TRK-T3 oncoprotein
protein.
Length = 591
Score = 140 bits (339), Expect = 3e-32
Identities = 64/159 (40%), Positives = 98/159 (61%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P PL G LL A Q+A GM YLA +H DLA RN L+ VVKI DFG++R +Y+
Sbjct: 414 PGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYST 473
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
+ Y+ + LP++W+ E ++ R F+T+SDVWS+G+VLWE+F+ K P+ +S T+ +
Sbjct: 474 DYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAID 533
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTEL 952
++ G LE+P +Y +M CW ++P R S ++
Sbjct: 534 CITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV 572
Score = 53.6 bits (123), Expect = 4e-06
Identities = 29/103 (28%), Positives = 58/103 (56%), Gaps = 5/103 (4%)
Query: 606 REKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMV 665
R + +LG GAFG V+ AE+ ++ + VAVK +K +++ + E +++
Sbjct: 302 RRDIVLKWELGEGAFGKVFLAESHNLLPEQDKMLVAVKALKEASESAR-QDFQREAELLT 360
Query: 666 HLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKH 708
L +H +IV G CT+ R L+++ EY ++G+++ +++ H
Sbjct: 361 ML-QHQHIVRFFGVCTE---GRPLLMVFEYMRHGDLNRFLRSH 399
>X74765-1|CAB58562.1| 450|Homo sapiens protein tyrosine kinase
protein.
Length = 450
Score = 140 bits (339), Expect = 3e-32
Identities = 73/185 (39%), Positives = 107/185 (57%), Gaps = 9/185 (4%)
Query: 774 YIQQEWQTKYEGDYI-YECHQPRPLTSGH-LLGWAFQIARGMEYLANRKVLHGDLAARNV 831
YI E+ K G + Y + R + G LL ++ + MEYL +H DLAARNV
Sbjct: 263 YIVTEYMAK--GSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNV 320
Query: 832 LLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIV 891
L+++DNV K+ DFGL + + ++ K LPVKW A E + ++ FST+SDVWS+GI+
Sbjct: 321 LVSEDNVAKVSDFGLTKEASSTQDTGK-----LPVKWTAPEALREKKFSTKSDVWSFGIL 375
Query: 892 LWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTE 951
LWE++S + PYP I D++ + G +++ P +Y VM CWH RPSF +
Sbjct: 376 LWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQ 435
Query: 952 LQEIL 956
L+E L
Sbjct: 436 LREQL 440
>X62947-1|CAA44719.1| 503|Homo sapiens 55 kd protein protein.
Length = 503
Score = 140 bits (339), Expect = 3e-32
Identities = 64/159 (40%), Positives = 98/159 (61%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P PL G LL A Q+A GM YLA +H DLA RN L+ VVKI DFG++R +Y+
Sbjct: 326 PGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYST 385
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
+ Y+ + LP++W+ E ++ R F+T+SDVWS+G+VLWE+F+ K P+ +S T+ +
Sbjct: 386 DYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAID 445
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTEL 952
++ G LE+P +Y +M CW ++P R S ++
Sbjct: 446 CITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV 484
Score = 53.2 bits (122), Expect = 5e-06
Identities = 29/103 (28%), Positives = 57/103 (55%), Gaps = 5/103 (4%)
Query: 606 REKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMV 665
R + +LG GAFG V+ AE ++ + VAVK +K +++ + E +++
Sbjct: 214 RRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESAR-QDFQREAELLT 272
Query: 666 HLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKH 708
L +H +IV G CT+ R L+++ EY ++G+++ +++ H
Sbjct: 273 ML-QHQHIVRFFGVCTE---GRPLLMVFEYMRHGDLNRFLRSH 311
>X60702-1|CAA43113.1| 803|Homo sapiens tyrosine kinase protein.
Length = 803
Score = 140 bits (339), Expect = 3e-32
Identities = 67/173 (38%), Positives = 101/173 (58%), Gaps = 3/173 (1%)
Query: 793 QPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLA---DDNVVKICDFGLARS 849
QP PL LL A IA+G YL +H D+AARN LL+ V KI DFG+AR
Sbjct: 550 QPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARD 609
Query: 850 MYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPT 909
+Y Y++ + + LPVKW+ E ++ IF++++D WS+G++LWE+FSL PYP +
Sbjct: 610 IYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQ 669
Query: 910 DLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLED 962
++L ++ G R++ P +Y +M +CW +P RPSF + E L +D
Sbjct: 670 EVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQD 722
>X60114-1|CAA42713.1| 450|Homo sapiens put. cytoplasmic tyrosine
kinase protein.
Length = 450
Score = 140 bits (339), Expect = 3e-32
Identities = 73/185 (39%), Positives = 107/185 (57%), Gaps = 9/185 (4%)
Query: 774 YIQQEWQTKYEGDYI-YECHQPRPLTSGH-LLGWAFQIARGMEYLANRKVLHGDLAARNV 831
YI E+ K G + Y + R + G LL ++ + MEYL +H DLAARNV
Sbjct: 263 YIVTEYMAK--GSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNV 320
Query: 832 LLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIV 891
L+++DNV K+ DFGL + + ++ K LPVKW A E + ++ FST+SDVWS+GI+
Sbjct: 321 LVSEDNVAKVSDFGLTKEASSTQDTGK-----LPVKWTAPEALREKKFSTKSDVWSFGIL 375
Query: 892 LWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTE 951
LWE++S + PYP I D++ + G +++ P +Y VM CWH RPSF +
Sbjct: 376 LWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQ 435
Query: 952 LQEIL 956
L+E L
Sbjct: 436 LREQL 440
>X59932-1|CAA42556.1| 450|Homo sapiens c-src-kinase protein.
Length = 450
Score = 140 bits (339), Expect = 3e-32
Identities = 73/185 (39%), Positives = 107/185 (57%), Gaps = 9/185 (4%)
Query: 774 YIQQEWQTKYEGDYI-YECHQPRPLTSGH-LLGWAFQIARGMEYLANRKVLHGDLAARNV 831
YI E+ K G + Y + R + G LL ++ + MEYL +H DLAARNV
Sbjct: 263 YIVTEYMAK--GSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNV 320
Query: 832 LLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIV 891
L+++DNV K+ DFGL + + ++ K LPVKW A E + ++ FST+SDVWS+GI+
Sbjct: 321 LVSEDNVAKVSDFGLTKEASSTQDTGK-----LPVKWTAPEALREKKFSTKSDVWSFGIL 375
Query: 892 LWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTE 951
LWE++S + PYP I D++ + G +++ P +Y VM CWH RPSF +
Sbjct: 376 LWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQ 435
Query: 952 LQEIL 956
L+E L
Sbjct: 436 LREQL 440
>S59184-1|AAB26341.1| 606|Homo sapiens RYK protein.
Length = 606
Score = 140 bits (339), Expect = 3e-32
Identities = 69/174 (39%), Positives = 106/174 (60%), Gaps = 2/174 (1%)
Query: 788 IYECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLA 847
+ E + P+ ++ L+ A QIA GM YLA R+V+H DLAARN ++ D VKI D L+
Sbjct: 425 LVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALS 484
Query: 848 RSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGI-VLWEMFSLAKTPYP-N 905
R ++ + + +N PV+W+A+E +V+ FS+ SDVW++G+ LWE+ +L +TPY +
Sbjct: 485 RDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVNSLWELMTLGQTPYTLD 544
Query: 906 ISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNF 959
I P ++ +L DG R+ +P D L+ VM CW P RP F +L + L F
Sbjct: 545 IDPFEMAAYLKDGYRIAQPITCPDELFAVMACCWALDPEERPRFQQLVQCLTEF 598
>M23102-1|AAA36770.1| 790|Homo sapiens protein ( Human trk
proto-oncogene insert of pLM6. ).
Length = 790
Score = 140 bits (339), Expect = 3e-32
Identities = 64/159 (40%), Positives = 98/159 (61%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P PL G LL A Q+A GM YLA +H DLA RN L+ VVKI DFG++R +Y+
Sbjct: 613 PGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYST 672
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
+ Y+ + LP++W+ E ++ R F+T+SDVWS+G+VLWE+F+ K P+ +S T+ +
Sbjct: 673 DYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAID 732
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTEL 952
++ G LE+P +Y +M CW ++P R S ++
Sbjct: 733 CITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV 771
Score = 53.2 bits (122), Expect = 5e-06
Identities = 29/103 (28%), Positives = 57/103 (55%), Gaps = 5/103 (4%)
Query: 606 REKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMV 665
R + +LG GAFG V+ AE ++ + VAVK +K +++ + E +++
Sbjct: 501 RRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESAR-QDFQREAELLT 559
Query: 666 HLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKH 708
L +H +IV G CT+ R L+++ EY ++G+++ +++ H
Sbjct: 560 ML-QHQHIVRFFGVCTE---GRPLLMVFEYMRHGDLNRFLRSH 598
>D16105-1|BAA03679.1| 864|Homo sapiens leukocyte tyrosine kinase
protein.
Length = 864
Score = 140 bits (339), Expect = 3e-32
Identities = 67/173 (38%), Positives = 101/173 (58%), Gaps = 3/173 (1%)
Query: 793 QPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLA---DDNVVKICDFGLARS 849
QP PL LL A IA+G YL +H D+AARN LL+ V KI DFG+AR
Sbjct: 611 QPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARD 670
Query: 850 MYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPT 909
+Y Y++ + + LPVKW+ E ++ IF++++D WS+G++LWE+FSL PYP +
Sbjct: 671 IYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQ 730
Query: 910 DLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGNFLED 962
++L ++ G R++ P +Y +M +CW +P RPSF + E L +D
Sbjct: 731 EVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQD 783
>DQ075211-1|AAY57329.1| 450|Homo sapiens c-src tyrosine kinase
protein.
Length = 450
Score = 140 bits (339), Expect = 3e-32
Identities = 73/185 (39%), Positives = 107/185 (57%), Gaps = 9/185 (4%)
Query: 774 YIQQEWQTKYEGDYI-YECHQPRPLTSGH-LLGWAFQIARGMEYLANRKVLHGDLAARNV 831
YI E+ K G + Y + R + G LL ++ + MEYL +H DLAARNV
Sbjct: 263 YIVTEYMAK--GSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNV 320
Query: 832 LLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIV 891
L+++DNV K+ DFGL + + ++ K LPVKW A E + ++ FST+SDVWS+GI+
Sbjct: 321 LVSEDNVAKVSDFGLTKEASSTQDTGK-----LPVKWTAPEALREKKFSTKSDVWSFGIL 375
Query: 892 LWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTE 951
LWE++S + PYP I D++ + G +++ P +Y VM CWH RPSF +
Sbjct: 376 LWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQ 435
Query: 952 LQEIL 956
L+E L
Sbjct: 436 LREQL 440
>CR541960-1|CAG46758.1| 450|Homo sapiens CSK protein.
Length = 450
Score = 140 bits (339), Expect = 3e-32
Identities = 73/185 (39%), Positives = 107/185 (57%), Gaps = 9/185 (4%)
Query: 774 YIQQEWQTKYEGDYI-YECHQPRPLTSGH-LLGWAFQIARGMEYLANRKVLHGDLAARNV 831
YI E+ K G + Y + R + G LL ++ + MEYL +H DLAARNV
Sbjct: 263 YIVTEYMAK--GSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNV 320
Query: 832 LLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIV 891
L+++DNV K+ DFGL + + ++ K LPVKW A E + ++ FST+SDVWS+GI+
Sbjct: 321 LVSEDNVAKVSDFGLTKEASSTQDTGK-----LPVKWTAPEALREKKFSTKSDVWSFGIL 375
Query: 892 LWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTE 951
LWE++S + PYP I D++ + G +++ P +Y VM CWH RPSF +
Sbjct: 376 LWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQ 435
Query: 952 LQEIL 956
L+E L
Sbjct: 436 LREQL 440
>BC106073-1|AAI06074.1| 450|Homo sapiens c-src tyrosine kinase
protein.
Length = 450
Score = 140 bits (339), Expect = 3e-32
Identities = 73/185 (39%), Positives = 107/185 (57%), Gaps = 9/185 (4%)
Query: 774 YIQQEWQTKYEGDYI-YECHQPRPLTSGH-LLGWAFQIARGMEYLANRKVLHGDLAARNV 831
YI E+ K G + Y + R + G LL ++ + MEYL +H DLAARNV
Sbjct: 263 YIVTEYMAK--GSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNV 320
Query: 832 LLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIV 891
L+++DNV K+ DFGL + + ++ K LPVKW A E + ++ FST+SDVWS+GI+
Sbjct: 321 LVSEDNVAKVSDFGLTKEASSTQDTGK-----LPVKWTAPEALREKKFSTKSDVWSFGIL 375
Query: 892 LWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTE 951
LWE++S + PYP I D++ + G +++ P +Y VM CWH RPSF +
Sbjct: 376 LWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQ 435
Query: 952 LQEIL 956
L+E L
Sbjct: 436 LREQL 440
>BC104875-1|AAI04876.1| 450|Homo sapiens c-src tyrosine kinase
protein.
Length = 450
Score = 140 bits (339), Expect = 3e-32
Identities = 73/185 (39%), Positives = 107/185 (57%), Gaps = 9/185 (4%)
Query: 774 YIQQEWQTKYEGDYI-YECHQPRPLTSGH-LLGWAFQIARGMEYLANRKVLHGDLAARNV 831
YI E+ K G + Y + R + G LL ++ + MEYL +H DLAARNV
Sbjct: 263 YIVTEYMAK--GSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNV 320
Query: 832 LLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIV 891
L+++DNV K+ DFGL + + ++ K LPVKW A E + ++ FST+SDVWS+GI+
Sbjct: 321 LVSEDNVAKVSDFGLTKEASSTQDTGK-----LPVKWTAPEALREKKFSTKSDVWSFGIL 375
Query: 892 LWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTE 951
LWE++S + PYP I D++ + G +++ P +Y VM CWH RPSF +
Sbjct: 376 LWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQ 435
Query: 952 LQEIL 956
L+E L
Sbjct: 436 LREQL 440
>BC104847-1|AAI04848.1| 450|Homo sapiens c-src tyrosine kinase
protein.
Length = 450
Score = 140 bits (339), Expect = 3e-32
Identities = 73/185 (39%), Positives = 107/185 (57%), Gaps = 9/185 (4%)
Query: 774 YIQQEWQTKYEGDYI-YECHQPRPLTSGH-LLGWAFQIARGMEYLANRKVLHGDLAARNV 831
YI E+ K G + Y + R + G LL ++ + MEYL +H DLAARNV
Sbjct: 263 YIVTEYMAK--GSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNV 320
Query: 832 LLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIV 891
L+++DNV K+ DFGL + + ++ K LPVKW A E + ++ FST+SDVWS+GI+
Sbjct: 321 LVSEDNVAKVSDFGLTKEASSTQDTGK-----LPVKWTAPEALREKKFSTKSDVWSFGIL 375
Query: 892 LWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTE 951
LWE++S + PYP I D++ + G +++ P +Y VM CWH RPSF +
Sbjct: 376 LWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQ 435
Query: 952 LQEIL 956
L+E L
Sbjct: 436 LREQL 440
>BC062580-1|AAH62580.1| 795|Homo sapiens NTRK1 protein protein.
Length = 795
Score = 140 bits (339), Expect = 3e-32
Identities = 64/159 (40%), Positives = 98/159 (61%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P PL G LL A Q+A GM YLA +H DLA RN L+ VVKI DFG++R +Y+
Sbjct: 618 PGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYST 677
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
+ Y+ + LP++W+ E ++ R F+T+SDVWS+G+VLWE+F+ K P+ +S T+ +
Sbjct: 678 DYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAID 737
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTEL 952
++ G LE+P +Y +M CW ++P R S ++
Sbjct: 738 CITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV 776
Score = 53.2 bits (122), Expect = 5e-06
Identities = 29/103 (28%), Positives = 57/103 (55%), Gaps = 5/103 (4%)
Query: 606 REKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMV 665
R + +LG GAFG V+ AE ++ + VAVK +K +++ + E +++
Sbjct: 506 RRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESAR-QDFQREAELLT 564
Query: 666 HLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKH 708
L +H +IV G CT+ R L+++ EY ++G+++ +++ H
Sbjct: 565 ML-QHQHIVRFFGVCTE---GRPLLMVFEYMRHGDLNRFLRSH 603
>AL158169-4|CAH70010.1| 790|Homo sapiens neurotrophic tyrosine
kinase, receptor, type 1 protein.
Length = 790
Score = 140 bits (339), Expect = 3e-32
Identities = 64/159 (40%), Positives = 98/159 (61%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P PL G LL A Q+A GM YLA +H DLA RN L+ VVKI DFG++R +Y+
Sbjct: 613 PGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYST 672
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
+ Y+ + LP++W+ E ++ R F+T+SDVWS+G+VLWE+F+ K P+ +S T+ +
Sbjct: 673 DYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAID 732
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTEL 952
++ G LE+P +Y +M CW ++P R S ++
Sbjct: 733 CITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV 771
Score = 53.2 bits (122), Expect = 5e-06
Identities = 29/103 (28%), Positives = 57/103 (55%), Gaps = 5/103 (4%)
Query: 606 REKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMV 665
R + +LG GAFG V+ AE ++ + VAVK +K +++ + E +++
Sbjct: 501 RRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESAR-QDFQREAELLT 559
Query: 666 HLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKH 708
L +H +IV G CT+ R L+++ EY ++G+++ +++ H
Sbjct: 560 ML-QHQHIVRFFGVCTE---GRPLLMVFEYMRHGDLNRFLRSH 598
>AB019488-1|BAA34355.1| 796|Homo sapiens TRKA protein.
Length = 796
Score = 140 bits (339), Expect = 3e-32
Identities = 64/159 (40%), Positives = 98/159 (61%)
Query: 794 PRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNN 853
P PL G LL A Q+A GM YLA +H DLA RN L+ VVKI DFG++R +Y+
Sbjct: 619 PGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYST 678
Query: 854 EEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLR 913
+ Y+ + LP++W+ E ++ R F+T+SDVWS+G+VLWE+F+ K P+ +S T+ +
Sbjct: 679 DYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAID 738
Query: 914 WLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTEL 952
++ G LE+P +Y +M CW ++P R S ++
Sbjct: 739 CITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV 777
Score = 53.2 bits (122), Expect = 5e-06
Identities = 29/103 (28%), Positives = 57/103 (55%), Gaps = 5/103 (4%)
Query: 606 REKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMV 665
R + +LG GAFG V+ AE ++ + VAVK +K +++ + E +++
Sbjct: 507 RRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESAR-QDFQREAELLT 565
Query: 666 HLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKH 708
L +H +IV G CT+ R L+++ EY ++G+++ +++ H
Sbjct: 566 ML-QHQHIVRFFGVCTE---GRPLLMVFEYMRHGDLNRFLRSH 604
>U12140-1|AAC51371.1| 822|Homo sapiens tyrosine kinase receptor
p145TRK-B protein.
Length = 822
Score = 140 bits (338), Expect = 3e-32
Identities = 63/169 (37%), Positives = 106/169 (62%)
Query: 790 ECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARS 849
E + P LT +L A QIA GM YLA++ +H DLA RN L+ ++ +VKI DFG++R
Sbjct: 641 EGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRD 700
Query: 850 MYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPT 909
+Y+ + Y+ ++ LP++W+ E ++ R F+T+SDVWS G+VLWE+F+ K P+ +S
Sbjct: 701 VYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNN 760
Query: 910 DLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGN 958
+++ ++ G L++P +Y +ML CW ++P R + + +L N
Sbjct: 761 EVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQN 809
Score = 55.6 bits (128), Expect = 1e-06
Identities = 32/103 (31%), Positives = 56/103 (54%), Gaps = 5/103 (4%)
Query: 606 REKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMV 665
R + ++LG GAFG V+ AE + + VAVK +K +DN K E +++
Sbjct: 535 RHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNAR-KDFHREAELLT 593
Query: 666 HLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKH 708
+L +H +IV G C + LI++ EY K+G+++ +++ H
Sbjct: 594 NL-QHEHIVKFYGVC---VEGDPLIMVFEYMKHGDLNKFLRAH 632
Score = 36.7 bits (81), Expect = 0.48
Identities = 13/58 (22%), Positives = 30/58 (51%)
Query: 459 EGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIYECVALN 516
+G P+P + W+ + +++ + + + NHT + +++N +NG Y +A N
Sbjct: 308 KGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKN 365
Score = 36.3 bits (80), Expect = 0.64
Identities = 26/79 (32%), Positives = 35/79 (44%), Gaps = 5/79 (6%)
Query: 302 ENSEMNFACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYLKISVQASG-VIT 360
E + +C V G P+P++ W N ++ T Q SL IS SG I+
Sbjct: 210 EGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSL----RITNISSDDSGKQIS 265
Query: 361 CNAHNSKGEYFDSSTLLVY 379
C A N GE DS L V+
Sbjct: 266 CVAENLVGEDQDSVNLTVH 284
>U05012-1|AAA75374.1| 825|Homo sapiens TrkC protein.
Length = 825
Score = 140 bits (338), Expect = 3e-32
Identities = 62/155 (40%), Positives = 104/155 (67%)
Query: 802 LLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARSMYNNEEYQKKEN 861
+L A QIA GM YLA++ +H DLA RN L+ + +VKI DFG++R +Y+ + Y+ +
Sbjct: 656 MLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGH 715
Query: 862 SPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPTDLLRWLSDGNRL 921
+ LP++W+ E ++ R F+T+SDVWS+G++LWE+F+ K P+ +S T+++ ++ G L
Sbjct: 716 TMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVL 775
Query: 922 EKPPFADDRLYNVMLRCWHQKPTARPSFTELQEIL 956
E+P +Y+VML CW ++P R + E+ +IL
Sbjct: 776 ERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKIL 810
Score = 45.2 bits (102), Expect = 0.001
Identities = 30/103 (29%), Positives = 52/103 (50%), Gaps = 5/103 (4%)
Query: 606 REKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMV 665
R + ++LG GAFG V+ AE + + VAVK +K K E +++
Sbjct: 535 RRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALK-DPTLAARKDFQREAELLT 593
Query: 666 HLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKH 708
+L +H +IV G C LI++ EY K+G+++ +++ H
Sbjct: 594 NL-QHEHIVKFYGVCGD---GDPLIMVFEYMKHGDLNKFLRAH 632
Score = 33.5 bits (73), Expect = 4.5
Identities = 25/94 (26%), Positives = 40/94 (42%), Gaps = 3/94 (3%)
Query: 288 PEAKLLNNRIIKRLENSEMNFACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYA-KT 346
PE + + + R E C +G PLPDV WI + + T +++A
Sbjct: 210 PEISVSHVNLTVR-EGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINL 268
Query: 347 DYLKISVQASG-VITCNAHNSKGEYFDSSTLLVY 379
+ ++ + +G +TC A N G S L VY
Sbjct: 269 TLVNVTSEDNGFTLTCIAENVVGMSNASVALTVY 302
>S76473-1|AAB33109.1| 822|Homo sapiens trkB protein.
Length = 822
Score = 140 bits (338), Expect = 3e-32
Identities = 63/169 (37%), Positives = 106/169 (62%)
Query: 790 ECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARS 849
E + P LT +L A QIA GM YLA++ +H DLA RN L+ ++ +VKI DFG++R
Sbjct: 641 EGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRD 700
Query: 850 MYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPT 909
+Y+ + Y+ ++ LP++W+ E ++ R F+T+SDVWS G+VLWE+F+ K P+ +S
Sbjct: 701 VYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNN 760
Query: 910 DLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGN 958
+++ ++ G L++P +Y +ML CW ++P R + + +L N
Sbjct: 761 EVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQN 809
Score = 55.6 bits (128), Expect = 1e-06
Identities = 32/103 (31%), Positives = 56/103 (54%), Gaps = 5/103 (4%)
Query: 606 REKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMV 665
R + ++LG GAFG V+ AE + + VAVK +K +DN K E +++
Sbjct: 535 RHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNAR-KDFHREAELLT 593
Query: 666 HLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKH 708
+L +H +IV G C + LI++ EY K+G+++ +++ H
Sbjct: 594 NL-QHEHIVKFYGVC---VEGDPLIMVFEYMKHGDLNKFLRAH 632
Score = 36.7 bits (81), Expect = 0.48
Identities = 13/58 (22%), Positives = 30/58 (51%)
Query: 459 EGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIYECVALN 516
+G P+P + W+ + +++ + + + NHT + +++N +NG Y +A N
Sbjct: 308 KGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKN 365
Score = 36.3 bits (80), Expect = 0.64
Identities = 26/79 (32%), Positives = 35/79 (44%), Gaps = 5/79 (6%)
Query: 302 ENSEMNFACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYLKISVQASG-VIT 360
E + +C V G P+P++ W N ++ T Q SL IS SG I+
Sbjct: 210 EGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSL----RITNISSDDSGKQIS 265
Query: 361 CNAHNSKGEYFDSSTLLVY 379
C A N GE DS L V+
Sbjct: 266 CVAENLVGEDQDSVNLTVH 284
>AL596132-4|CAH72315.1| 822|Homo sapiens neurotrophic tyrosine
kinase, receptor, type 2 protein.
Length = 822
Score = 140 bits (338), Expect = 3e-32
Identities = 63/169 (37%), Positives = 106/169 (62%)
Query: 790 ECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARS 849
E + P LT +L A QIA GM YLA++ +H DLA RN L+ ++ +VKI DFG++R
Sbjct: 641 EGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRD 700
Query: 850 MYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPT 909
+Y+ + Y+ ++ LP++W+ E ++ R F+T+SDVWS G+VLWE+F+ K P+ +S
Sbjct: 701 VYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNN 760
Query: 910 DLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGN 958
+++ ++ G L++P +Y +ML CW ++P R + + +L N
Sbjct: 761 EVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQN 809
Score = 55.6 bits (128), Expect = 1e-06
Identities = 32/103 (31%), Positives = 56/103 (54%), Gaps = 5/103 (4%)
Query: 606 REKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMV 665
R + ++LG GAFG V+ AE + + VAVK +K +DN K E +++
Sbjct: 535 RHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNAR-KDFHREAELLT 593
Query: 666 HLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKH 708
+L +H +IV G C + LI++ EY K+G+++ +++ H
Sbjct: 594 NL-QHEHIVKFYGVC---VEGDPLIMVFEYMKHGDLNKFLRAH 632
Score = 36.7 bits (81), Expect = 0.48
Identities = 13/58 (22%), Positives = 30/58 (51%)
Query: 459 EGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIYECVALN 516
+G P+P + W+ + +++ + + + NHT + +++N +NG Y +A N
Sbjct: 308 KGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKN 365
Score = 36.3 bits (80), Expect = 0.64
Identities = 26/79 (32%), Positives = 35/79 (44%), Gaps = 5/79 (6%)
Query: 302 ENSEMNFACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYLKISVQASG-VIT 360
E + +C V G P+P++ W N ++ T Q SL IS SG I+
Sbjct: 210 EGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSL----RITNISSDDSGKQIS 265
Query: 361 CNAHNSKGEYFDSSTLLVY 379
C A N GE DS L V+
Sbjct: 266 CVAENLVGEDQDSVNLTVH 284
>AL596132-3|CAH72316.1| 838|Homo sapiens neurotrophic tyrosine
kinase, receptor, type 2 protein.
Length = 838
Score = 140 bits (338), Expect = 3e-32
Identities = 63/169 (37%), Positives = 106/169 (62%)
Query: 790 ECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARS 849
E + P LT +L A QIA GM YLA++ +H DLA RN L+ ++ +VKI DFG++R
Sbjct: 657 EGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRD 716
Query: 850 MYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPT 909
+Y+ + Y+ ++ LP++W+ E ++ R F+T+SDVWS G+VLWE+F+ K P+ +S
Sbjct: 717 VYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNN 776
Query: 910 DLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGN 958
+++ ++ G L++P +Y +ML CW ++P R + + +L N
Sbjct: 777 EVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQN 825
Score = 55.6 bits (128), Expect = 1e-06
Identities = 32/103 (31%), Positives = 56/103 (54%), Gaps = 5/103 (4%)
Query: 606 REKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMV 665
R + ++LG GAFG V+ AE + + VAVK +K +DN K E +++
Sbjct: 551 RHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNAR-KDFHREAELLT 609
Query: 666 HLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKH 708
+L +H +IV G C + LI++ EY K+G+++ +++ H
Sbjct: 610 NL-QHEHIVKFYGVC---VEGDPLIMVFEYMKHGDLNKFLRAH 648
Score = 36.7 bits (81), Expect = 0.48
Identities = 13/58 (22%), Positives = 30/58 (51%)
Query: 459 EGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIYECVALN 516
+G P+P + W+ + +++ + + + NHT + +++N +NG Y +A N
Sbjct: 308 KGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKN 365
Score = 36.3 bits (80), Expect = 0.64
Identities = 26/79 (32%), Positives = 35/79 (44%), Gaps = 5/79 (6%)
Query: 302 ENSEMNFACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYLKISVQASG-VIT 360
E + +C V G P+P++ W N ++ T Q SL IS SG I+
Sbjct: 210 EGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSL----RITNISSDDSGKQIS 265
Query: 361 CNAHNSKGEYFDSSTLLVY 379
C A N GE DS L V+
Sbjct: 266 CVAENLVGEDQDSVNLTVH 284
>AL445532-2|CAH71817.1| 822|Homo sapiens neurotrophic tyrosine
kinase, receptor, type 2 protein.
Length = 822
Score = 140 bits (338), Expect = 3e-32
Identities = 63/169 (37%), Positives = 106/169 (62%)
Query: 790 ECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARS 849
E + P LT +L A QIA GM YLA++ +H DLA RN L+ ++ +VKI DFG++R
Sbjct: 641 EGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRD 700
Query: 850 MYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPT 909
+Y+ + Y+ ++ LP++W+ E ++ R F+T+SDVWS G+VLWE+F+ K P+ +S
Sbjct: 701 VYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNN 760
Query: 910 DLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGN 958
+++ ++ G L++P +Y +ML CW ++P R + + +L N
Sbjct: 761 EVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQN 809
Score = 55.6 bits (128), Expect = 1e-06
Identities = 32/103 (31%), Positives = 56/103 (54%), Gaps = 5/103 (4%)
Query: 606 REKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMV 665
R + ++LG GAFG V+ AE + + VAVK +K +DN K E +++
Sbjct: 535 RHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNAR-KDFHREAELLT 593
Query: 666 HLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKH 708
+L +H +IV G C + LI++ EY K+G+++ +++ H
Sbjct: 594 NL-QHEHIVKFYGVC---VEGDPLIMVFEYMKHGDLNKFLRAH 632
Score = 36.7 bits (81), Expect = 0.48
Identities = 13/58 (22%), Positives = 30/58 (51%)
Query: 459 EGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIYECVALN 516
+G P+P + W+ + +++ + + + NHT + +++N +NG Y +A N
Sbjct: 308 KGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKN 365
Score = 36.3 bits (80), Expect = 0.64
Identities = 26/79 (32%), Positives = 35/79 (44%), Gaps = 5/79 (6%)
Query: 302 ENSEMNFACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYLKISVQASG-VIT 360
E + +C V G P+P++ W N ++ T Q SL IS SG I+
Sbjct: 210 EGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSL----RITNISSDDSGKQIS 265
Query: 361 CNAHNSKGEYFDSSTLLVY 379
C A N GE DS L V+
Sbjct: 266 CVAENLVGEDQDSVNLTVH 284
>AL445532-1|CAH71816.1| 838|Homo sapiens neurotrophic tyrosine
kinase, receptor, type 2 protein.
Length = 838
Score = 140 bits (338), Expect = 3e-32
Identities = 63/169 (37%), Positives = 106/169 (62%)
Query: 790 ECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARS 849
E + P LT +L A QIA GM YLA++ +H DLA RN L+ ++ +VKI DFG++R
Sbjct: 657 EGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRD 716
Query: 850 MYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPT 909
+Y+ + Y+ ++ LP++W+ E ++ R F+T+SDVWS G+VLWE+F+ K P+ +S
Sbjct: 717 VYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNN 776
Query: 910 DLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGN 958
+++ ++ G L++P +Y +ML CW ++P R + + +L N
Sbjct: 777 EVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQN 825
Score = 55.6 bits (128), Expect = 1e-06
Identities = 32/103 (31%), Positives = 56/103 (54%), Gaps = 5/103 (4%)
Query: 606 REKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMV 665
R + ++LG GAFG V+ AE + + VAVK +K +DN K E +++
Sbjct: 551 RHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNAR-KDFHREAELLT 609
Query: 666 HLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKH 708
+L +H +IV G C + LI++ EY K+G+++ +++ H
Sbjct: 610 NL-QHEHIVKFYGVC---VEGDPLIMVFEYMKHGDLNKFLRAH 648
Score = 36.7 bits (81), Expect = 0.48
Identities = 13/58 (22%), Positives = 30/58 (51%)
Query: 459 EGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIYECVALN 516
+G P+P + W+ + +++ + + + NHT + +++N +NG Y +A N
Sbjct: 308 KGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKN 365
Score = 36.3 bits (80), Expect = 0.64
Identities = 26/79 (32%), Positives = 35/79 (44%), Gaps = 5/79 (6%)
Query: 302 ENSEMNFACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYLKISVQASG-VIT 360
E + +C V G P+P++ W N ++ T Q SL IS SG I+
Sbjct: 210 EGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSL----RITNISSDDSGKQIS 265
Query: 361 CNAHNSKGEYFDSSTLLVY 379
C A N GE DS L V+
Sbjct: 266 CVAENLVGEDQDSVNLTVH 284
>AL390777-4|CAH72196.1| 822|Homo sapiens neurotrophic tyrosine
kinase, receptor, type 2 protein.
Length = 822
Score = 140 bits (338), Expect = 3e-32
Identities = 63/169 (37%), Positives = 106/169 (62%)
Query: 790 ECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARS 849
E + P LT +L A QIA GM YLA++ +H DLA RN L+ ++ +VKI DFG++R
Sbjct: 641 EGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRD 700
Query: 850 MYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPT 909
+Y+ + Y+ ++ LP++W+ E ++ R F+T+SDVWS G+VLWE+F+ K P+ +S
Sbjct: 701 VYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNN 760
Query: 910 DLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGN 958
+++ ++ G L++P +Y +ML CW ++P R + + +L N
Sbjct: 761 EVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQN 809
Score = 55.6 bits (128), Expect = 1e-06
Identities = 32/103 (31%), Positives = 56/103 (54%), Gaps = 5/103 (4%)
Query: 606 REKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMV 665
R + ++LG GAFG V+ AE + + VAVK +K +DN K E +++
Sbjct: 535 RHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNAR-KDFHREAELLT 593
Query: 666 HLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKH 708
+L +H +IV G C + LI++ EY K+G+++ +++ H
Sbjct: 594 NL-QHEHIVKFYGVC---VEGDPLIMVFEYMKHGDLNKFLRAH 632
Score = 36.7 bits (81), Expect = 0.48
Identities = 13/58 (22%), Positives = 30/58 (51%)
Query: 459 EGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIYECVALN 516
+G P+P + W+ + +++ + + + NHT + +++N +NG Y +A N
Sbjct: 308 KGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKN 365
Score = 36.3 bits (80), Expect = 0.64
Identities = 26/79 (32%), Positives = 35/79 (44%), Gaps = 5/79 (6%)
Query: 302 ENSEMNFACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYLKISVQASG-VIT 360
E + +C V G P+P++ W N ++ T Q SL IS SG I+
Sbjct: 210 EGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSL----RITNISSDDSGKQIS 265
Query: 361 CNAHNSKGEYFDSSTLLVY 379
C A N GE DS L V+
Sbjct: 266 CVAENLVGEDQDSVNLTVH 284
>AL390777-3|CAH72195.1| 838|Homo sapiens neurotrophic tyrosine
kinase, receptor, type 2 protein.
Length = 838
Score = 140 bits (338), Expect = 3e-32
Identities = 63/169 (37%), Positives = 106/169 (62%)
Query: 790 ECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARS 849
E + P LT +L A QIA GM YLA++ +H DLA RN L+ ++ +VKI DFG++R
Sbjct: 657 EGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRD 716
Query: 850 MYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPT 909
+Y+ + Y+ ++ LP++W+ E ++ R F+T+SDVWS G+VLWE+F+ K P+ +S
Sbjct: 717 VYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNN 776
Query: 910 DLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGN 958
+++ ++ G L++P +Y +ML CW ++P R + + +L N
Sbjct: 777 EVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQN 825
Score = 55.6 bits (128), Expect = 1e-06
Identities = 32/103 (31%), Positives = 56/103 (54%), Gaps = 5/103 (4%)
Query: 606 REKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMV 665
R + ++LG GAFG V+ AE + + VAVK +K +DN K E +++
Sbjct: 551 RHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNAR-KDFHREAELLT 609
Query: 666 HLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKH 708
+L +H +IV G C + LI++ EY K+G+++ +++ H
Sbjct: 610 NL-QHEHIVKFYGVC---VEGDPLIMVFEYMKHGDLNKFLRAH 648
Score = 36.7 bits (81), Expect = 0.48
Identities = 13/58 (22%), Positives = 30/58 (51%)
Query: 459 EGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIYECVALN 516
+G P+P + W+ + +++ + + + NHT + +++N +NG Y +A N
Sbjct: 308 KGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKN 365
Score = 36.3 bits (80), Expect = 0.64
Identities = 26/79 (32%), Positives = 35/79 (44%), Gaps = 5/79 (6%)
Query: 302 ENSEMNFACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYLKISVQASG-VIT 360
E + +C V G P+P++ W N ++ T Q SL IS SG I+
Sbjct: 210 EGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSL----RITNISSDDSGKQIS 265
Query: 361 CNAHNSKGEYFDSSTLLVY 379
C A N GE DS L V+
Sbjct: 266 CVAENLVGEDQDSVNLTVH 284
>AK223626-1|BAD97346.1| 449|Homo sapiens c-src tyrosine kinase
variant protein.
Length = 449
Score = 140 bits (338), Expect = 3e-32
Identities = 73/185 (39%), Positives = 106/185 (57%), Gaps = 10/185 (5%)
Query: 774 YIQQEWQTKYEGDYI-YECHQPRPLTSGH-LLGWAFQIARGMEYLANRKVLHGDLAARNV 831
YI E+ K G + Y + R + G LL ++ + MEYL +H DLAARNV
Sbjct: 263 YIVTEYMAK--GSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNV 320
Query: 832 LLADDNVVKICDFGLARSMYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIV 891
L+++DNV K+ DFGL + E ++ LPVKW A E + ++ FST+SDVWS+GI+
Sbjct: 321 LVSEDNVAKVSDFGLTK------EASTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGIL 374
Query: 892 LWEMFSLAKTPYPNISPTDLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTE 951
LWE++S + PYP I D++ + G +++ P +Y VM CWH RPSF +
Sbjct: 375 LWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQ 434
Query: 952 LQEIL 956
L+E L
Sbjct: 435 LREQL 439
>AF410899-1|AAL67965.1| 838|Homo sapiens neurotrophin receptor
tyrosine kinase type 2 protein.
Length = 838
Score = 140 bits (338), Expect = 3e-32
Identities = 63/169 (37%), Positives = 106/169 (62%)
Query: 790 ECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARS 849
E + P LT +L A QIA GM YLA++ +H DLA RN L+ ++ +VKI DFG++R
Sbjct: 657 EGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRD 716
Query: 850 MYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPT 909
+Y+ + Y+ ++ LP++W+ E ++ R F+T+SDVWS G+VLWE+F+ K P+ +S
Sbjct: 717 VYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNN 776
Query: 910 DLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGN 958
+++ ++ G L++P +Y +ML CW ++P R + + +L N
Sbjct: 777 EVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQN 825
Score = 55.6 bits (128), Expect = 1e-06
Identities = 32/103 (31%), Positives = 56/103 (54%), Gaps = 5/103 (4%)
Query: 606 REKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMV 665
R + ++LG GAFG V+ AE + + VAVK +K +DN K E +++
Sbjct: 551 RHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNAR-KDFHREAELLT 609
Query: 666 HLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKH 708
+L +H +IV G C + LI++ EY K+G+++ +++ H
Sbjct: 610 NL-QHEHIVKFYGVC---VEGDPLIMVFEYMKHGDLNKFLRAH 648
Score = 36.7 bits (81), Expect = 0.48
Identities = 13/58 (22%), Positives = 30/58 (51%)
Query: 459 EGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIYECVALN 516
+G P+P + W+ + +++ + + + NHT + +++N +NG Y +A N
Sbjct: 308 KGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKN 365
Score = 36.3 bits (80), Expect = 0.64
Identities = 26/79 (32%), Positives = 35/79 (44%), Gaps = 5/79 (6%)
Query: 302 ENSEMNFACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYLKISVQASG-VIT 360
E + +C V G P+P++ W N ++ T Q SL IS SG I+
Sbjct: 210 EGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSL----RITNISSDDSGKQIS 265
Query: 361 CNAHNSKGEYFDSSTLLVY 379
C A N GE DS L V+
Sbjct: 266 CVAENLVGEDQDSVNLTVH 284
>AF400441-1|AAK92490.1| 822|Homo sapiens neurotrophic tyrosine
kinase receptor type 2 protein.
Length = 822
Score = 140 bits (338), Expect = 3e-32
Identities = 63/169 (37%), Positives = 106/169 (62%)
Query: 790 ECHQPRPLTSGHLLGWAFQIARGMEYLANRKVLHGDLAARNVLLADDNVVKICDFGLARS 849
E + P LT +L A QIA GM YLA++ +H DLA RN L+ ++ +VKI DFG++R
Sbjct: 641 EGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRD 700
Query: 850 MYNNEEYQKKENSPLPVKWLAIECMVDRIFSTQSDVWSYGIVLWEMFSLAKTPYPNISPT 909
+Y+ + Y+ ++ LP++W+ E ++ R F+T+SDVWS G+VLWE+F+ K P+ +S
Sbjct: 701 VYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNN 760
Query: 910 DLLRWLSDGNRLEKPPFADDRLYNVMLRCWHQKPTARPSFTELQEILGN 958
+++ ++ G L++P +Y +ML CW ++P R + + +L N
Sbjct: 761 EVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQN 809
Score = 55.6 bits (128), Expect = 1e-06
Identities = 32/103 (31%), Positives = 56/103 (54%), Gaps = 5/103 (4%)
Query: 606 REKLTFGKQLGAGAFGVVYKAEARGIINAEVTTPVAVKMVKRTADNMYIKALASELKIMV 665
R + ++LG GAFG V+ AE + + VAVK +K +DN K E +++
Sbjct: 535 RHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNAR-KDFHREAELLT 593
Query: 666 HLGKHVNIVNLLGACTKHIAKRELIVIVEYCKYGNIHNYMQKH 708
+L +H +IV G C + LI++ EY K+G+++ +++ H
Sbjct: 594 NL-QHEHIVKFYGVC---VEGDPLIMVFEYMKHGDLNKFLRAH 632
Score = 36.7 bits (81), Expect = 0.48
Identities = 13/58 (22%), Positives = 30/58 (51%)
Query: 459 EGVPRPTIYWYKDDELISNNSGYKLFVDIVNHTIVNSTFEIENMQEKDNGIYECVALN 516
+G P+P + W+ + +++ + + + NHT + +++N +NG Y +A N
Sbjct: 308 KGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKN 365
Score = 36.3 bits (80), Expect = 0.64
Identities = 26/79 (32%), Positives = 35/79 (44%), Gaps = 5/79 (6%)
Query: 302 ENSEMNFACKVTGYPLPDVTWIFSNDEEHELSSTKSEQESLYAKTDYLKISVQASG-VIT 360
E + +C V G P+P++ W N ++ T Q SL IS SG I+
Sbjct: 210 EGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSL----RITNISSDDSGKQIS 265
Query: 361 CNAHNSKGEYFDSSTLLVY 379
C A N GE DS L V+
Sbjct: 266 CVAENLVGEDQDSVNLTVH 284
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.316 0.133 0.396
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 178,488,682
Number of Sequences: 224733
Number of extensions: 8012246
Number of successful extensions: 33290
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 2127
Number of HSP's successfully gapped in prelim test: 1048
Number of HSP's that attempted gapping in prelim test: 19154
Number of HSP's gapped (non-prelim): 10868
length of query: 1158
length of database: 73,234,838
effective HSP length: 98
effective length of query: 1060
effective length of database: 51,211,004
effective search space: 54283664240
effective search space used: 54283664240
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.6 bits)
S2: 71 (32.7 bits)
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