Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001162-TA|BGIBMGA001162-PA|IPR002401|E-class P450, group
I, IPR001128|Cytochrome P450
(556 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
BC060857-1|AAH60857.1| 525|Homo sapiens cytochrome P450, family... 226 1e-58
AY422002-1|AAR31180.1| 525|Homo sapiens cytochrome P450 4V2 pro... 226 1e-58
AK126473-1|BAC86562.1| 503|Homo sapiens protein ( Homo sapiens ... 226 1e-58
AK122600-1|BAC85487.1| 525|Homo sapiens protein ( Homo sapiens ... 226 1e-58
D26480-1|BAA05490.1| 520|Homo sapiens leukotriene B4 omega-hydr... 189 2e-47
BC067439-1|AAH67439.1| 520|Homo sapiens cytochrome P450, family... 189 2e-47
BC067437-1|AAH67437.1| 520|Homo sapiens cytochrome P450, family... 189 2e-47
AF467894-1|AAL67578.1| 520|Homo sapiens cytochrome P450, subfam... 189 2e-47
AC005336-1|AAC27730.1| 520|Homo sapiens CYP4F2 protein. 189 2e-47
BC067440-1|AAH67440.1| 520|Homo sapiens cytochrome P450, family... 188 4e-47
AB015306-1|BAA75823.1| 520|Homo sapiens Leukotriene B4 omega-hy... 188 4e-47
BC035350-1|AAH35350.1| 524|Homo sapiens cytochrome P450, family... 188 6e-47
AY358977-1|AAQ89336.1| 524|Homo sapiens CYP4F12 protein. 188 6e-47
AY008841-1|AAG33247.1| 524|Homo sapiens cytochrome P450 isoform... 188 6e-47
AC004523-1|AAC11543.1| 458|Homo sapiens F22329_1 protein. 188 6e-47
AB035131-1|BAB18270.1| 524|Homo sapiens cytochrome P450 protein. 188 6e-47
AB035130-1|BAB18269.1| 524|Homo sapiens cytochrome P450 protein. 188 6e-47
AF133298-1|AAD49566.1| 520|Homo sapiens cytochrome P450 protein. 186 2e-46
U02388-1|AAC50052.2| 520|Homo sapiens cytochrome P450 4F2 protein. 184 6e-46
AY792513-1|AAV40834.1| 520|Homo sapiens cytochrome P450, family... 183 2e-45
AF054821-1|AAC08589.1| 520|Homo sapiens cytochrome P-450 protein. 183 2e-45
X16699-1|CAA34672.1| 511|Homo sapiens protein ( Human mRNA for ... 182 2e-45
J02871-1|AAA35712.1| 511|Homo sapiens protein ( Human lung cyto... 182 2e-45
DQ518907-1|ABF47106.1| 511|Homo sapiens cytochrome P450, family... 182 2e-45
BC017758-1|AAH17758.1| 512|Homo sapiens cytochrome P450, family... 182 2e-45
AY151049-1|AAN72312.1| 497|Homo sapiens pulmonary cytochrome P4... 182 2e-45
AY151048-1|AAN72311.1| 512|Homo sapiens pulmonary cytochrome P4... 182 2e-45
AY064485-1|AAL57720.1| 511|Homo sapiens cytochrome P450 protein. 182 2e-45
AL593856-7|CAI16983.1| 497|Homo sapiens cytochrome P450, family... 182 2e-45
AL593856-6|CAI16982.1| 512|Homo sapiens cytochrome P450, family... 182 2e-45
AL593856-5|CAI16981.1| 511|Homo sapiens cytochrome P450, family... 182 2e-45
AL356793-4|CAI22559.1| 511|Homo sapiens cytochrome P450, family... 182 2e-45
AL356793-3|CAI22557.1| 512|Homo sapiens cytochrome P450, family... 182 2e-45
AL356793-2|CAI22558.1| 497|Homo sapiens cytochrome P450, family... 182 2e-45
D12620-1|BAA02144.1| 520|Homo sapiens cytochrome P-450LTBV prot... 182 3e-45
AY064486-1|AAL57721.1| 511|Homo sapiens cytochrome P450 protein. 182 3e-45
AB002461-1|BAA25991.1| 520|Homo sapiens leukotriene B4 omega-hy... 182 3e-45
AB002454-1|BAA25990.1| 520|Homo sapiens leukotriene B4 omega-hy... 182 3e-45
S67580-1|AAB29502.1| 519|Homo sapiens fatty acid omega-hydroxyl... 181 7e-45
AF491285-1|AAM09532.1| 511|Homo sapiens cytochrome P450 protein. 181 7e-45
AY280371-1|AAQ21367.1| 519|Homo sapiens cytochrome P450 4A22K p... 180 9e-45
L04751-1|AAA58436.1| 519|Homo sapiens cytochrome P450 protein. 180 2e-44
D26481-1|BAA05491.1| 519|Homo sapiens fatty acids omega-hydroxy... 180 2e-44
AY369778-1|AAQ56847.1| 519|Homo sapiens cytochrome P450, family... 180 2e-44
AY280372-1|AAQ21368.1| 519|Homo sapiens cytochrome P450 4A22 pr... 180 2e-44
AL731892-3|CAH72778.1| 519|Homo sapiens cytochrome P450, family... 180 2e-44
AF525488-1|AAO16078.1| 519|Homo sapiens cytochrome P450, subfam... 178 5e-44
BC016853-1|AAH16853.1| 524|Homo sapiens CYP4F11 protein protein. 176 2e-43
AL135960-10|CAI19737.1| 519|Homo sapiens cytochrome P450, famil... 175 3e-43
AF208532-1|AAF76722.1| 519|Homo sapiens fatty acid omega-hydrox... 175 3e-43
S67581-1|AAB29503.1| 591|Homo sapiens fatty acid omega-hydroxyl... 175 3e-43
AF236085-1|AAG15889.1| 524|Homo sapiens CYP4F11 protein. 175 3e-43
D13705-1|BAA02864.1| 521|Homo sapiens fatty acid omega-hydroxyl... 174 6e-43
BC093896-1|AAH93896.1| 531|Homo sapiens cytochrome P450, family... 168 5e-41
BC093894-1|AAH93894.1| 531|Homo sapiens cytochrome P450, family... 168 5e-41
BC069351-1|AAH69351.1| 531|Homo sapiens cytochrome P450, family... 168 5e-41
AK096820-1|BAC04868.1| 531|Homo sapiens protein ( Homo sapiens ... 168 5e-41
BC028102-1|AAH28102.1| 509|Homo sapiens cytochrome P450, family... 166 2e-40
AY358537-1|AAQ88901.1| 509|Homo sapiens EFSW1929 protein. 166 2e-40
AM040940-1|CAJ13826.1| 509|Homo sapiens cytochrome P450 protein. 166 2e-40
AL450996-1|CAH71035.1| 509|Homo sapiens cytochrome P450, family... 166 2e-40
AK131355-1|BAD18508.1| 508|Homo sapiens protein ( Homo sapiens ... 166 2e-40
AK098065-1|BAC05226.1| 509|Homo sapiens protein ( Homo sapiens ... 166 2e-40
AK091806-1|BAC03751.1| 444|Homo sapiens protein ( Homo sapiens ... 166 2e-40
BC041158-1|AAH41158.1| 455|Homo sapiens CYP4A11 protein protein. 151 8e-36
AL731892-4|CAH72779.1| 455|Homo sapiens cytochrome P450, family... 151 8e-36
AY358631-1|AAQ88994.1| 505|Homo sapiens EPSW3060 protein. 150 1e-35
AY262056-1|AAO89257.1| 505|Homo sapiens cytochrome P450 protein. 150 1e-35
AL450996-2|CAH71036.1| 505|Homo sapiens cytochrome P450, family... 150 1e-35
AL135960-6|CAI19734.1| 505|Homo sapiens cytochrome P450, family... 150 1e-35
AL135960-11|CAI19738.1| 455|Homo sapiens cytochrome P450, famil... 147 1e-34
M18907-1|AAA35745.1| 503|Homo sapiens protein ( Human P450 mRNA... 140 1e-32
DQ924960-1|ABI96208.1| 503|Homo sapiens cytochrome P450 family ... 140 1e-32
DQ005611-1|AAY16980.1| 503|Homo sapiens cytochrome P450, family... 140 1e-32
BC101631-1|AAI01632.1| 503|Homo sapiens cytochrome P450, subfam... 140 1e-32
BC069418-1|AAH69418.1| 503|Homo sapiens cytochrome P450, family... 140 1e-32
AJ563377-1|CAD91345.1| 353|Homo sapiens cytochrome P450 protein. 140 1e-32
AJ563376-2|CAD91645.1| 430|Homo sapiens cytochrome P450 protein. 140 1e-32
AJ563375-1|CAD91343.1| 503|Homo sapiens cytochrome P450 protein. 140 1e-32
AF280107-2|AAG32290.1| 503|Homo sapiens cytochrome P450 polypep... 140 1e-32
AF209389-1|AAF21034.1| 503|Homo sapiens cytochrome P450 IIIA4 p... 140 1e-32
M14096-1|AAA35744.1| 503|Homo sapiens protein ( Human cytochrom... 140 2e-32
J04449-1|AAA35747.1| 502|Homo sapiens cytochrome P450 nifedipin... 140 2e-32
X12387-1|CAA30944.1| 503|Homo sapiens protein ( Human mRNA for ... 139 2e-32
M13785-1|AAA35742.1| 504|Homo sapiens protein ( Human liver glu... 138 4e-32
D00003-1|BAA00001.1| 504|Homo sapiens cytochrome P-450 protein. 138 4e-32
AF182273-1|AAF13598.1| 503|Homo sapiens cytochrome P450-3A4 pro... 138 5e-32
D00408-1|BAA00310.1| 503|Homo sapiens cytochrome P-450 HFLa pro... 136 2e-31
BC067436-1|AAH67436.1| 503|Homo sapiens cytochrome P450, family... 136 2e-31
AF315325-1|AAG48618.1| 535|Homo sapiens cytochrome P450 variant... 136 2e-31
AF280107-3|AAG32289.1| 503|Homo sapiens cytochrome P450 polypep... 136 2e-31
J04813-1|AAA02993.1| 502|Homo sapiens cytochrome P450 PCN3 prot... 135 4e-31
BC033862-1|AAH33862.1| 502|Homo sapiens cytochrome P450, family... 135 4e-31
AC005020-1|AAS02016.1| 502|Homo sapiens unknown protein. 135 4e-31
AY390424-1|AAQ92352.1| 503|Homo sapiens cytochrome P450 CYP3A43... 134 6e-31
AK223008-1|BAD96728.1| 502|Homo sapiens cytochrome P450, family... 134 8e-31
BC100981-1|AAI00982.1| 393|Homo sapiens CYP3A43 protein protein. 134 1e-30
AY390425-1|AAQ92353.1| 503|Homo sapiens cytochrome P450 CYP3A43... 134 1e-30
AF337813-1|AAK38841.1| 503|Homo sapiens cytochrome P450 subfami... 134 1e-30
AF319634-1|AAK00325.1| 503|Homo sapiens cytochrome P450 CYP3A43... 134 1e-30
AF280108-1|AAG33009.1| 503|Homo sapiens cytochrome P450 subfami... 134 1e-30
AC011904-4|AAS07395.1| 503|Homo sapiens unknown protein. 134 1e-30
X71480-1|CAA50586.1| 141|Homo sapiens cytochrome P450 protein. 133 1e-30
AF280109-1|AAG33010.1| 504|Homo sapiens cytochrome P450 subfami... 130 2e-29
AC011904-5|AAS07394.1| 504|Homo sapiens unknown protein. 130 2e-29
AL135960-9|CAI19736.1| 421|Homo sapiens cytochrome P450, family... 116 3e-25
BC022539-1|AAH22539.1| 500|Homo sapiens cytochrome P450, family... 109 2e-23
AF094480-1|AAD41244.1| 500|Homo sapiens cholesterol 24-hydroxyl... 109 2e-23
AF233624-1|AAF99278.1| 534|Homo sapiens thromboxane synthase pr... 106 2e-22
M80647-1|AAA60618.1| 534|Homo sapiens thromboxane synthase prot... 106 2e-22
BC041157-1|AAH41157.1| 534|Homo sapiens thromboxane A synthase ... 106 2e-22
BC014117-1|AAH14117.1| 466|Homo sapiens TBXAS1 protein protein. 106 2e-22
AK223466-1|BAD97186.1| 534|Homo sapiens thromboxane A synthase ... 106 2e-22
AF233625-1|AAF99279.1| 534|Homo sapiens thromboxane synthase pr... 106 2e-22
AF233623-1|AAF99277.1| 534|Homo sapiens thromboxane synthase pr... 106 2e-22
AF233620-1|AAF99274.1| 534|Homo sapiens thromboxane synthase pr... 106 2e-22
AF233619-1|AAF99273.1| 534|Homo sapiens thromboxane synthase pr... 106 2e-22
AF233618-1|AAF99272.1| 534|Homo sapiens thromboxane synthase pr... 106 2e-22
AF233617-1|AAF99271.1| 534|Homo sapiens thromboxane synthase pr... 106 2e-22
AF233616-1|AAF99270.1| 534|Homo sapiens thromboxane synthase pr... 106 2e-22
AF233615-1|AAF99269.1| 534|Homo sapiens thromboxane synthase pr... 106 2e-22
AF233621-1|AAF99275.1| 534|Homo sapiens thromboxane synthase pr... 105 3e-22
D34625-1|BAA07011.1| 533|Homo sapiens thromboxane synthase prot... 105 5e-22
AF233622-1|AAF99276.1| 534|Homo sapiens thromboxane synthase pr... 105 5e-22
AL358613-3|CAH72804.1| 428|Homo sapiens cytochrome P450, family... 104 9e-22
AL358613-2|CAH72803.1| 497|Homo sapiens cytochrome P450, family... 104 9e-22
AF005418-1|AAB88881.1| 497|Homo sapiens retinoic acid hydroxyla... 104 9e-22
D12621-1|BAA02145.1| 389|Homo sapiens cytochrome P-450LTBV prot... 101 5e-21
BC032322-1|AAH32322.1| 509|Homo sapiens cytochrome P450, family... 101 9e-21
U51692-1|AAC50951.1| 503|Homo sapiens lanosterol 14-alpha demet... 100 1e-20
U23942-1|AAB39951.1| 509|Homo sapiens lanosterol 14-demethylase... 100 1e-20
D55653-1|BAA09512.1| 509|Homo sapiens lanosterol 14-demethylase... 100 1e-20
AC000120-2|AAB46356.1| 509|Homo sapiens unknown protein. 100 1e-20
Y07508-1|CAA68807.1| 503|Homo sapiens protein ( Human mRNA for ... 97 2e-19
X13589-1|CAA31929.1| 503|Homo sapiens protein ( Human mRNA for ... 97 2e-19
M30804-1|AAA35728.1| 503|Homo sapiens protein ( Human aromatase... 97 2e-19
M28420-1|AAA52141.1| 419|Homo sapiens cytochrome P-450 aromatas... 97 2e-19
M22246-1|AAA35557.1| 503|Homo sapiens protein ( Human aromatase... 97 2e-19
M18856-1|AAA35556.1| 419|Homo sapiens protein ( Human aromatase... 97 2e-19
J04127-1|AAA52132.1| 503|Homo sapiens CYP19 protein. 97 2e-19
DQ118405-1|AAZ23558.1| 503|Homo sapiens cytochrome P450 subfami... 97 2e-19
BC107785-1|AAI07786.1| 503|Homo sapiens cytochrome P450, family... 97 2e-19
BC035959-1|AAH35959.1| 503|Homo sapiens cytochrome P450, family... 97 2e-19
AY957953-1|AAX44046.1| 503|Homo sapiens cytochrome P450, family... 97 2e-19
BC132767-1|AAI32768.1| 544|Homo sapiens cytochrome P450, family... 95 4e-19
AY343323-1|AAQ21380.1| 544|Homo sapiens cytochrome P450 protein. 95 4e-19
AJ563378-3|CAD91347.1| 173|Homo sapiens hypothetical protein pr... 95 6e-19
AJ563378-2|CAD91647.1| 160|Homo sapiens cytochrome P450 protein. 95 6e-19
AF280110-1|AAG33011.1| 420|Homo sapiens cytochrome P450 subfami... 94 1e-18
X59812-1|CAA42481.1| 530|Homo sapiens Vitamin D3 25-hydroxylase... 93 2e-18
M62401-1|AAA52142.1| 531|Homo sapiens sterol 27-hydroxylase pro... 93 2e-18
BC051851-1|AAH51851.1| 531|Homo sapiens cytochrome P450, family... 93 2e-18
BC040430-1|AAH40430.1| 531|Homo sapiens cytochrome P450, family... 93 2e-18
AY178622-1|AAO21126.1| 531|Homo sapiens steroid hydroxylase pro... 93 2e-18
AK097373-1|BAC05026.1| 340|Homo sapiens protein ( Homo sapiens ... 93 3e-18
BC100982-1|AAI00983.1| 280|Homo sapiens CYP3A43 protein protein. 92 5e-18
AY696295-1|AAU10524.1| 292|Homo sapiens cytochrome P450 protein. 92 5e-18
X13930-1|CAA32118.1| 494|Homo sapiens protein ( Human CYP2A4 mR... 91 7e-18
X13929-1|CAA32117.1| 448|Homo sapiens P-450 IIA3 protein (1 is ... 91 7e-18
M33318-1|AAA52067.1| 494|Homo sapiens CYP2A protein. 91 7e-18
L13286-1|AAA62379.1| 513|Homo sapiens 1,25-dihydroxyvitamin D3 ... 91 7e-18
BC096256-1|AAH96256.1| 494|Homo sapiens cytochrome P450, family... 91 7e-18
BC096255-1|AAH96255.1| 494|Homo sapiens cytochrome P450, family... 91 7e-18
BC096254-1|AAH96254.1| 494|Homo sapiens cytochrome P450, family... 91 7e-18
BC096253-1|AAH96253.3| 494|Homo sapiens cytochrome P450, family... 91 7e-18
AF182275-1|AAF13600.1| 494|Homo sapiens cytochrome P450-2A6 pro... 91 7e-18
U37143-1|AAC50370.2| 502|Homo sapiens cytochrome P450 monooxyge... 91 9e-18
BC032594-1|AAH32594.1| 502|Homo sapiens cytochrome P450, family... 91 9e-18
AY426985-1|AAQ93356.1| 502|Homo sapiens cytochrome P450, family... 91 9e-18
AK090886-1|BAC03539.1| 337|Homo sapiens protein ( Homo sapiens ... 91 9e-18
AF272142-1|AAM44456.1| 502|Homo sapiens cytochrome P450 protein. 91 9e-18
AB080265-1|BAB85489.1| 502|Homo sapiens cytochrome P450 2J2 pro... 91 1e-17
M33317-1|AAA52138.1| 494|Homo sapiens CYP2A protein. 90 2e-17
X13897-1|CAA32097.1| 489|Homo sapiens protein ( Human mRNA for ... 90 2e-17
BC117165-1|AAI17166.1| 494|Homo sapiens cytochrome P450, family... 90 2e-17
AK131190-1|BAD18388.1| 372|Homo sapiens .-.-). protein. 90 2e-17
BC039307-1|AAH39307.1| 372|Homo sapiens FLJ16008 protein protein. 89 3e-17
S67623-1|AAB29308.1| 257|Homo sapiens 25-hydroxyvitamin D 24-hy... 89 4e-17
AY858838-1|AAW50795.1| 372|Homo sapiens vitamin D 24-hydroxylas... 89 4e-17
AL138805-3|CAB91829.1| 514|Homo sapiens cytochrome P450, family... 89 4e-17
AL138805-1|CAM27342.1| 372|Homo sapiens cytochrome P450, family... 89 4e-17
AY513608-1|AAR90939.1| 494|Homo sapiens cytochrome P450 2A13 va... 89 5e-17
AY513606-1|AAR90937.1| 494|Homo sapiens cytochrome P450 2A13 va... 89 5e-17
AY513605-1|AAR90936.1| 494|Homo sapiens cytochrome P450 2A13 va... 89 5e-17
AY513604-1|AAR90935.1| 494|Homo sapiens cytochrome P450 2A13 va... 89 5e-17
AF209774-1|AAG35775.1| 494|Homo sapiens cytochrome P450 2A13 pr... 89 5e-17
X55764-1|CAA39290.1| 503|Homo sapiens protein ( Human mRNA for ... 88 7e-17
X54741-1|CAA38539.1| 503|Homo sapiens aldosterone synthase (P-... 88 7e-17
M29874-1|AAA52144.1| 491|Homo sapiens CYP2B protein. 88 7e-17
D13752-1|BAA02899.1| 503|Homo sapiens steroid 18-hydroxylase pr... 88 7e-17
DQ298753-1|ABB84469.1| 491|Homo sapiens cytochrome P450, family... 88 7e-17
BC067431-1|AAH67431.1| 491|Homo sapiens cytochrome P450, family... 88 7e-17
BC067430-1|AAH67430.1| 491|Homo sapiens cytochrome P450, family... 88 7e-17
AY513609-1|AAR90940.1| 494|Homo sapiens cytochrome P450 2A13 va... 88 7e-17
AF182277-1|AAF13602.1| 491|Homo sapiens cytochrome P450-2B6 pro... 88 7e-17
AC023172-1|AAF32444.1| 491|Homo sapiens CYP2B6 protein. 88 7e-17
DQ282151-1|ABB77899.1| 496|Homo sapiens cytochrome P450 2D6 pro... 88 9e-17
M33388-1|AAA53500.1| 497|Homo sapiens cytochrome P450 IID6 prot... 87 2e-16
M33189-1|AAA35737.1| 500|Homo sapiens protein ( Human debrisoqu... 87 2e-16
M24499-1|AAA36403.1| 373|Homo sapiens cytochrome P450db1 protein. 87 2e-16
DQ282154-1|ABB77902.1| 497|Homo sapiens cytochrome P450 2D6 pro... 87 2e-16
DQ282152-1|ABB77900.1| 497|Homo sapiens cytochrome P450 2D6 pro... 87 2e-16
DQ282146-1|ABB77897.1| 497|Homo sapiens cytochrome P450 2D6 pro... 87 2e-16
DQ282145-1|ABB77896.1| 497|Homo sapiens cytochrome P450 2D6 pro... 87 2e-16
DQ282144-1|ABB77895.1| 497|Homo sapiens cytochrome P450 2D6 pro... 87 2e-16
DQ211354-2|ABB01372.1| 497|Homo sapiens cytochrome P450 2D6 pro... 87 2e-16
DQ211353-2|ABB01371.1| 497|Homo sapiens cytochrome P450 2D6 pro... 87 2e-16
DQ211353-1|ABB01370.1| 497|Homo sapiens cytochrome P450 2D6 pro... 87 2e-16
BC075024-1|AAH75024.1| 497|Homo sapiens cytochrome P450, family... 87 2e-16
BC075023-1|AAH75023.1| 497|Homo sapiens cytochrome P450, family... 87 2e-16
AY545216-1|AAS55001.1| 497|Homo sapiens cytochrome P4502D6 prot... 87 2e-16
AF478474-1|AAL84813.1| 503|Homo sapiens mutated cytochrome P-45... 87 2e-16
AB209492-1|BAD92729.1| 566|Homo sapiens Debrisoquine 4-hydroxyl... 87 2e-16
Y00498-1|CAA68550.1| 490|Homo sapiens IIC2 protein. 87 2e-16
X58906-1|CAA41709.1| 495|Homo sapiens steroid 21-monooxygenase ... 87 2e-16
M32879-1|AAA52149.1| 503|Homo sapiens CYP11B1 protein. 87 2e-16
M21942-1|AAA52161.1| 462|Homo sapiens CYP2C protein. 87 2e-16
M17397-1|AAA35739.1| 490|Homo sapiens protein ( Human cytochrom... 87 2e-16
BC096287-1|AAH96287.1| 503|Homo sapiens cytochrome P450, family... 87 2e-16
BC096285-1|AAH96285.1| 574|Homo sapiens CYP11B1 protein protein. 87 2e-16
BC020596-1|AAH20596.1| 490|Homo sapiens cytochrome P450, family... 87 2e-16
AY514490-1|AAR89907.1| 490|Homo sapiens cytochrome P450, family... 87 2e-16
AL359672-5|CAH71307.1| 490|Homo sapiens cytochrome P450, family... 87 2e-16
X51535-1|CAA35915.1| 210|Homo sapiens cytochrome P-450 HPH (120... 86 3e-16
X08006-1|CAA30807.1| 497|Homo sapiens cytochrome P450 db1 protein. 86 3e-16
M20403-1|AAA52153.1| 497|Homo sapiens CYP2D protein. 86 3e-16
M32881-1|AAA35741.1| 503|Homo sapiens protein ( Human steroid 1... 86 4e-16
BC106758-1|AAI06759.1| 497|Homo sapiens cytochrome P450, family... 86 4e-16
AM183949-1|CAJ75803.1| 494|Homo sapiens steroid 21-hydroxylase,... 86 4e-16
S46963-1|AAB23864.2| 477|Homo sapiens cytochrome P-450 protein. 85 5e-16
M28548-1|AAA52065.1| 495|Homo sapiens protein ( Human mutant 21... 85 5e-16
M26856-1|AAA52064.1| 495|Homo sapiens protein ( Human 21-hydrox... 85 5e-16
M21940-1|AAA52159.1| 383|Homo sapiens CYP2C protein. 85 5e-16
M21939-1|AAA52158.1| 485|Homo sapiens CYP2C protein. 85 5e-16
M21550-1|AAA52063.1| 495|Homo sapiens CYP21 protein. 85 5e-16
M15331-1|AAA52157.1| 485|Homo sapiens CYP2C protein. 85 5e-16
M13936-1|AAA59695.1| 494|Homo sapiens CYP21P protein. 85 5e-16
D00173-1|BAA00123.1| 487|Homo sapiens cytochrome P-450 protein. 85 5e-16
BX679671-8|CAM26071.1| 464|Homo sapiens cytochrome P450, family... 85 5e-16
BX679671-7|CAM26070.1| 494|Homo sapiens cytochrome P450, family... 85 5e-16
BC125182-1|AAI25183.1| 494|Homo sapiens cytochrome P450, family... 85 5e-16
BC125181-1|AAI25182.1| 495|Homo sapiens cytochrome P450, family... 85 5e-16
BC125054-1|AAI25055.1| 490|Homo sapiens cytochrome P450, family... 85 5e-16
AY702706-1|AAT94065.1| 490|Homo sapiens cytochrome P450, family... 85 5e-16
AY341248-1|AAP88931.1| 490|Homo sapiens cytochrome P450, family... 85 5e-16
AM183951-1|CAJ75805.1| 494|Homo sapiens steroid 21-hydroxylase,... 85 5e-16
AM183947-1|CAJ75801.1| 494|Homo sapiens steroid 21-hydroxylase,... 85 5e-16
AM183946-1|CAJ75800.1| 494|Homo sapiens steroid 21-hydroxylase,... 85 5e-16
AM183945-1|CAJ75799.1| 494|Homo sapiens steroid 21-hydroxylase,... 85 5e-16
AM086565-1|CAJ31104.1| 494|Homo sapiens steroid 21-hydroxylase,... 85 5e-16
AM086564-1|CAJ31103.1| 494|Homo sapiens steroid 21-hydroxylase,... 85 5e-16
AL929593-2|CAI41778.1| 465|Homo sapiens cytochrome P450, family... 85 5e-16
AL929593-1|CAI41779.1| 495|Homo sapiens cytochrome P450, family... 85 5e-16
AL662849-19|CAI17480.1| 465|Homo sapiens cytochrome P450, famil... 85 5e-16
AL662849-18|CAI17479.1| 495|Homo sapiens cytochrome P450, famil... 85 5e-16
AL645922-24|CAI41754.1| 495|Homo sapiens cytochrome P450, famil... 85 5e-16
AL645922-23|CAI41755.1| 465|Homo sapiens cytochrome P450, famil... 85 5e-16
AL359672-1|CAH71303.1| 490|Homo sapiens cytochrome P450, family... 85 5e-16
AL049547-7|CAB89301.1| 495|Homo sapiens dJ34F7.3 (cytochrome P4... 85 5e-16
AF077974-1|AAD45405.1| 403|Homo sapiens cytochrome P450 21-hydr... 85 5e-16
AF019413-2|AAB67982.1| 495|Homo sapiens cytochrome P450 21-hydr... 85 5e-16
U22028-1|AAB40519.1| 494|Homo sapiens cytochrome P450 protein. 85 6e-16
M21941-1|AAA52160.1| 480|Homo sapiens CYP2C protein. 85 6e-16
DQ282162-1|ABB77909.1| 500|Homo sapiens cytochrome P450 2D6 pro... 85 6e-16
DQ282160-1|ABB77908.1| 497|Homo sapiens cytochrome P450 2D6 pro... 85 6e-16
DQ282159-1|ABB77907.1| 497|Homo sapiens cytochrome P450 2D6 pro... 85 6e-16
DQ282158-1|ABB77906.1| 497|Homo sapiens cytochrome P450 2D6 pro... 85 6e-16
DQ282157-1|ABB77905.1| 497|Homo sapiens cytochrome P450 2D6 pro... 85 6e-16
DQ282156-1|ABB77904.1| 497|Homo sapiens cytochrome P450 2D6 pro... 85 6e-16
DQ282155-1|ABB77903.1| 497|Homo sapiens cytochrome P450 2D6 pro... 85 6e-16
DQ282147-1|ABB77898.1| 497|Homo sapiens cytochrome P450 2D6 pro... 85 6e-16
CR456430-1|CAG30316.1| 446|Homo sapiens CYP2D6 protein. 85 6e-16
BC126858-1|AAI26859.1| 497|Homo sapiens cytochrome P450, family... 85 6e-16
BC109205-1|AAI09206.1| 512|Homo sapiens cytochrome P450, family... 85 6e-16
BC106757-1|AAI06758.1| 446|Homo sapiens cytochrome P450, family... 85 6e-16
BC069443-1|AAH69443.1| 512|Homo sapiens cytochrome P450, family... 85 6e-16
BC067432-1|AAH67432.1| 497|Homo sapiens cytochrome P450, family... 85 6e-16
BC066877-1|AAH66877.1| 446|Homo sapiens CYP2D6 protein protein. 85 6e-16
AF252297-1|AAF76003.1| 512|Homo sapiens cytochrome P450 retinoi... 85 6e-16
AC007002-1|AAY14690.1| 512|Homo sapiens unknown protein. 85 6e-16
BC104909-1|AAI04910.1| 501|Homo sapiens cytochrome P450, family... 85 8e-16
BC104907-1|AAI04908.1| 501|Homo sapiens cytochrome P450, family... 85 8e-16
AY323817-1|AAQ23114.1| 501|Homo sapiens cytochrome P450 2R1 pro... 85 8e-16
AM183950-1|CAJ75804.1| 494|Homo sapiens steroid 21-hydroxylase,... 85 8e-16
AK054616-1|BAB70774.1| 465|Homo sapiens protein ( Homo sapiens ... 85 8e-16
DQ282153-1|ABB77901.1| 497|Homo sapiens cytochrome P450 2D6 pro... 84 1e-15
U22029-1|AAB40520.1| 494|Homo sapiens cytochrome P450 protein. 84 1e-15
M17252-1|AAA59985.1| 230|Homo sapiens CYP21 protein. 84 1e-15
AY064484-1|AAL57719.1| 295|Homo sapiens truncated cytochrome P4... 84 1e-15
AM183948-1|CAJ75802.1| 494|Homo sapiens steroid 21-hydroxylase ... 83 2e-15
M61858-1|AAA52145.1| 370|Homo sapiens CYP2C17 protein. 83 2e-15
BC067433-1|AAH67433.1| 493|Homo sapiens cytochrome P450, family... 83 3e-15
X65962-1|CAA46778.1| 356|Homo sapiens cytochrome P-450 II C pro... 82 4e-15
M61854-1|AAB59426.1| 490|Homo sapiens cytochrome protein. 82 4e-15
L39102-1|AAL31348.1| 217|Homo sapiens S-mephenytoin 4-hydroxyla... 82 4e-15
J02843-1|AAA52155.1| 493|Homo sapiens protein ( Human cytochrom... 82 4e-15
J02625-1|AAA35743.1| 493|Homo sapiens protein ( Human cytochrom... 82 4e-15
DQ515958-1|ABF47105.1| 493|Homo sapiens cytochrome P450, family... 82 4e-15
DQ149222-1|AAZ77710.1| 493|Homo sapiens cytochrome P450 2E1 pro... 82 4e-15
BC025761-1|AAH25761.2| 490|Homo sapiens cytochrome P450, family... 82 4e-15
AL161645-2|CAH70047.1| 493|Homo sapiens cytochrome P450, family... 82 4e-15
AF182276-1|AAF13601.1| 493|Homo sapiens cytochrome P450-2E1 pro... 82 4e-15
AF084225-1|AAD13753.1| 462|Homo sapiens cytochrome P450 2E1 pro... 82 4e-15
M12792-1|AAB59440.1| 494|Homo sapiens steroid 21-hydroxylase pr... 82 6e-15
L07093-1|AAA36660.1| 468|Homo sapiens cytochrome P450 protein. 82 6e-15
AY796203-1|AAV41877.1| 490|Homo sapiens cytochrome P450, family... 82 6e-15
AL583836-2|CAH74068.1| 490|Homo sapiens cytochrome P450, family... 82 6e-15
AL133513-2|CAH73444.1| 490|Homo sapiens cytochrome P450, family... 82 6e-15
U22027-1|AAB40518.1| 494|Homo sapiens cytochrome P450 protein. 81 8e-15
M61856-1|AAB59356.1| 490|Homo sapiens cytochrome protein. 81 8e-15
BX538127-1|CAD98029.1| 310|Homo sapiens hypothetical protein pr... 81 8e-15
BC096260-1|AAH96260.1| 431|Homo sapiens CYP2C18 protein protein. 81 8e-15
BC096258-1|AAH96258.1| 490|Homo sapiens cytochrome P450, family... 81 8e-15
BC096257-1|AAH96257.1| 490|Homo sapiens cytochrome P450, family... 81 8e-15
BC069666-1|AAH69666.1| 490|Homo sapiens cytochrome P450, family... 81 8e-15
AL583836-1|CAH74067.1| 490|Homo sapiens cytochrome P450, family... 81 8e-15
M63871-1|AAA59984.1| 508|Homo sapiens CYP17 protein. 81 1e-14
M31153-1|AAA52140.1| 508|Homo sapiens CYP17 protein. 81 1e-14
M19489-1|AAA36405.1| 508|Homo sapiens CYP17 protein. 81 1e-14
M14564-1|AAA52151.1| 508|Homo sapiens CYP17 protein. 81 1e-14
DQ530598-1|ABF50972.1| 508|Homo sapiens cytochrome P450, family... 81 1e-14
BT020000-1|AAV38803.1| 508|Homo sapiens cytochrome P450, family... 81 1e-14
BC067435-1|AAH67435.1| 493|Homo sapiens cytochrome P450, family... 81 1e-14
BC063388-1|AAH63388.1| 508|Homo sapiens cytochrome P450, family... 81 1e-14
BC062997-1|AAH62997.1| 508|Homo sapiens cytochrome P450, family... 81 1e-14
BC033691-1|AAH33691.1| 504|Homo sapiens cytochrome P450, family... 81 1e-14
AY358603-1|AAQ88966.1| 504|Homo sapiens Cytochrome p450 protein. 81 1e-14
AY288916-1|AAP31972.1| 508|Homo sapiens cytochrome P450, family... 81 1e-14
AL358790-3|CAI52498.1| 508|Homo sapiens cytochrome P450, family... 81 1e-14
AK223510-1|BAD97230.1| 490|Homo sapiens cytochrome P450, family... 81 1e-14
AF335278-1|AAK13498.1| 504|Homo sapiens cytochrome P450 2S1 pro... 81 1e-14
AF256213-1|AAG00416.1| 508|Homo sapiens 25- hydroxyvitamin D-1-... 81 1e-14
AF246895-1|AAF64299.1| 508|Homo sapiens 25-hydroxyvitamin D-1-a... 81 1e-14
AF027152-1|AAC51854.1| 508|Homo sapiens P450 25-hydroxyvitamin ... 81 1e-14
AF020192-1|AAC51853.1| 508|Homo sapiens 25-hydroxyvitamin D-1-a... 81 1e-14
AB006987-1|BAA23418.1| 508|Homo sapiens 25-hydroxyvitamin D3 1-... 81 1e-14
AB005990-1|BAA22657.1| 508|Homo sapiens 25-hydroxyvitamin D3 1a... 81 1e-14
AB005989-1|BAA22656.1| 508|Homo sapiens 25-hydroxyvitamin D3 1a... 81 1e-14
AB005038-1|BAA23416.1| 508|Homo sapiens 25-hydroxyvitamin D3 1-... 81 1e-14
L16876-1|AAA02630.1| 490|Homo sapiens cytochrome P-4502C18 prot... 79 4e-14
AK027605-1|BAB55227.1| 564|Homo sapiens protein ( Homo sapiens ... 79 5e-14
X05367-1|CAA28965.1| 521|Homo sapiens desmolase protein. 78 9e-14
M28253-1|AAA36404.1| 239|Homo sapiens cytochrome P-450-scc prot... 78 9e-14
M24667-1|AAA52148.1| 256|Homo sapiens steroid 11-beta-hydroxyla... 78 9e-14
M14565-1|AAA52162.1| 521|Homo sapiens CYP11A protein. 78 9e-14
BC032329-1|AAH32329.1| 521|Homo sapiens cytochrome P450, family... 78 9e-14
L16883-1|AAD13467.1| 169|Homo sapiens cytochrome P-450 2C protein. 77 2e-13
AF372573-1|AAL69652.1| 495|Homo sapiens cytochrome P450 2F1 pro... 76 3e-13
J02906-1|AAA52156.1| 491|Homo sapiens CYP2F1 protein. 75 5e-13
BC067429-1|AAH67429.1| 516|Homo sapiens cytochrome P450, family... 75 7e-13
K03192-1|AAA52147.1| 331|Homo sapiens CYP1A1 protein. 75 9e-13
AF221943-1|AAF86378.1| 175|Homo sapiens leukotriene B4 omega hy... 75 9e-13
X02612-1|CAA26458.1| 512|Homo sapiens cytochrome P(1)-450 protein. 73 2e-12
AK223108-1|BAD96828.1| 512|Homo sapiens cytochrome P450, family... 73 2e-12
X04300-1|CAA27843.1| 512|Homo sapiens P-450 c protein. 73 3e-12
M12079-1|AAA52152.1| 191|Homo sapiens POR protein. 73 3e-12
K03191-1|AAA52139.1| 512|Homo sapiens CYP1A1 protein. 73 3e-12
EF094025-1|ABK41999.1| 512|Homo sapiens cytochrome P450, family... 73 3e-12
BC023019-1|AAH23019.1| 512|Homo sapiens cytochrome P450, family... 73 3e-12
AY310359-1|AAQ76692.1| 484|Homo sapiens cytochrome P450 1A1 var... 73 3e-12
AM236047-1|CAJ84704.1| 251|Homo sapiens cytochrome P450 1A1 pro... 73 3e-12
AK223113-1|BAD96833.1| 512|Homo sapiens cytochrome P450, family... 73 3e-12
AF253322-1|AAK25727.1| 512|Homo sapiens cytochrome P450 protein. 73 3e-12
BC022851-1|AAH22851.1| 215|Homo sapiens CYP4A11 protein protein. 72 5e-12
Z00036-1|CAA77335.1| 515|Homo sapiens protein ( Human mRNA for ... 72 6e-12
M55053-1|AAA52146.1| 515|Homo sapiens cytochrome P3-450 protein. 72 6e-12
M31667-1|AAA52163.1| 515|Homo sapiens CYP1A2 protein. 72 6e-12
L00389-1|AAA35738.1| 516|Homo sapiens protein ( Human cytochrom... 72 6e-12
DQ022432-1|AAY26399.1| 516|Homo sapiens cytochrome P450, family... 72 6e-12
BC067428-1|AAH67428.1| 516|Homo sapiens cytochrome P450, family... 72 6e-12
BC067427-1|AAH67427.1| 516|Homo sapiens cytochrome P450, family... 72 6e-12
BC067426-1|AAH67426.1| 516|Homo sapiens cytochrome P450, family... 72 6e-12
BC067425-1|AAH67425.1| 516|Homo sapiens cytochrome P450, family... 72 6e-12
BC067424-1|AAH67424.1| 516|Homo sapiens cytochrome P450, family... 72 6e-12
AF253322-2|AAK25728.1| 516|Homo sapiens cytochrome P450 protein. 72 6e-12
AF182274-1|AAF13599.1| 516|Homo sapiens cytochrome P450-1A2 pro... 71 8e-12
AY359068-1|AAQ89427.1| 462|Homo sapiens P450-like protein protein. 71 1e-11
BC093022-1|AAH93022.1| 416|Homo sapiens CYP20A1 protein protein. 70 2e-11
BC033752-1|AAH33752.1| 462|Homo sapiens cytochrome P450, family... 70 2e-11
BC020616-1|AAH20616.1| 462|Homo sapiens cytochrome P450, family... 70 2e-11
M80646-1|AAA60617.1| 460|Homo sapiens thromboxane synthase prot... 70 2e-11
AY220845-1|AAO49806.1| 516|Homo sapiens cytochrome P450 protein. 70 2e-11
BC010358-1|AAH10358.1| 469|Homo sapiens cytochrome P450, family... 69 3e-11
AL591242-1|CAH73899.1| 469|Homo sapiens cytochrome P450, family... 69 3e-11
AL035670-1|CAI20276.1| 469|Homo sapiens cytochrome P450, family... 69 3e-11
AF237982-1|AAF63329.1| 469|Homo sapiens oxysterol 7alpha-hydrox... 69 3e-11
U03688-1|AAA19567.1| 543|Homo sapiens cytochrome P450 protein. 69 6e-11
BT020001-1|AAV38804.1| 543|Homo sapiens cytochrome P450, family... 69 6e-11
BC012049-1|AAH12049.1| 543|Homo sapiens cytochrome P450, family... 69 6e-11
AC009229-2|AAY15039.1| 543|Homo sapiens unknown protein. 69 6e-11
U56438-1|AAC50809.1| 543|Homo sapiens dioxin-inducible cytochro... 68 8e-11
AY393998-1|AAQ87875.1| 543|Homo sapiens cytochrome P450, family... 68 8e-11
AF450132-1|AAM50512.1| 543|Homo sapiens cytochrome P450 CYP1B1 ... 68 8e-11
AF183412-1|AAG09681.1| 435|Homo sapiens cytochrome P450 monooxy... 67 1e-10
M12078-1|AAA52154.1| 192|Homo sapiens POR protein. 67 2e-10
BT019979-1|AAV38782.1| 543|Homo sapiens cytochrome P450, family... 66 3e-10
AK000366-1|BAA91114.1| 408|Homo sapiens protein ( Homo sapiens ... 64 1e-09
AB209700-1|BAD92937.1| 336|Homo sapiens cytochrome P450, family... 64 1e-09
AM233517-1|CAJ80720.1| 175|Homo sapiens cytochrome P450 1A1 pro... 64 2e-09
AL358613-1|CAH72802.2| 522|Homo sapiens cytochrome P450, family... 60 2e-08
DQ016495-1|AAY34975.1| 195|Homo sapiens cytochrome P450 1B1 pro... 60 2e-08
BC128535-1|AAI28536.1| 143|Homo sapiens LOC283480 protein protein. 60 3e-08
AY356349-1|AAQ55485.1| 522|Homo sapiens cytochrome P450 protein. 59 4e-08
BC096259-1|AAH96259.1| 443|Homo sapiens CYP2C18 protein protein. 57 1e-07
AK127151-1|BAC86855.1| 146|Homo sapiens protein ( Homo sapiens ... 57 2e-07
AF040259-1|AAD10199.1| 144|Homo sapiens cytochrome P450 1A1 pro... 55 8e-07
AF297052-1|AAG31785.1| 500|Homo sapiens prostacyclin synthase p... 52 4e-06
D84124-1|BAA28219.1| 509|Homo sapiens prostacyclin synthase pro... 52 7e-06
D83402-1|BAA11910.1| 500|Homo sapiens prostacyclin synthase pro... 52 7e-06
D38145-1|BAA07343.1| 500|Homo sapiens prostacyclin synthase pro... 52 7e-06
BC101811-1|AAI01812.1| 500|Homo sapiens prostaglandin I2 (prost... 52 7e-06
BC101809-1|AAI01810.1| 500|Homo sapiens prostaglandin I2 (prost... 52 7e-06
AL118525-1|CAC14162.1| 500|Homo sapiens prostaglandin I2 (prost... 52 7e-06
AF297051-1|AAG31784.1| 500|Homo sapiens prostacyclin synthase p... 52 7e-06
AF297050-1|AAG31783.1| 500|Homo sapiens prostacyclin synthase p... 52 7e-06
AF297049-1|AAG31782.1| 500|Homo sapiens prostacyclin synthase p... 52 7e-06
AF297048-1|AAG31781.1| 500|Homo sapiens prostacyclin synthase p... 52 7e-06
L36085-1|AAC01761.1| 441|Homo sapiens thromboxane A2 synthase p... 51 1e-05
DQ680079-1|ABG25922.1| 347|Homo sapiens truncated cytochrome P4... 50 2e-05
AM233518-1|CAJ80721.1| 157|Homo sapiens cytochrome P450 1A1 pro... 50 2e-05
BC109084-1|AAI09085.1| 448|Homo sapiens CYP24A1 protein protein. 48 7e-05
BC109083-1|AAI09084.1| 448|Homo sapiens CYP24A1 protein protein. 48 7e-05
AL138805-2|CAM27343.1| 448|Homo sapiens cytochrome P450, family... 48 7e-05
AC005336-2|AAC27731.1| 93|Homo sapiens F20191_1, partial CDS p... 48 7e-05
AC011737-1|AAX88915.1| 382|Homo sapiens unknown protein. 47 2e-04
BC067444-1|AAH67444.1| 501|Homo sapiens cytochrome P450, family... 46 3e-04
BC067442-1|AAH67442.1| 501|Homo sapiens cytochrome P450, family... 46 3e-04
AK127234-1|BAC86895.1| 130|Homo sapiens ). protein. 46 3e-04
AJ563379-2|CAD91649.1| 84|Homo sapiens cytochrome P450 protein. 46 3e-04
AF090320-1|AAD19877.1| 501|Homo sapiens sterol 12-alpha-hydroxy... 46 3e-04
AF090318-1|AAC63037.1| 462|Homo sapiens sterol 12-alpha hydroxy... 46 3e-04
AY871801-1|AAX62803.1| 483|Homo sapiens cytochrome P450 family ... 46 3e-04
AJ877238-1|CAI47002.1| 97|Homo sapiens putative cytochrome P45... 46 5e-04
BC067441-1|AAH67441.1| 501|Homo sapiens cytochrome P450, family... 45 6e-04
BC067434-1|AAH67434.1| 501|Homo sapiens cytochrome P450, family... 45 6e-04
X56088-1|CAA39568.1| 504|Homo sapiens cholesterol 7-alpha-hydr... 44 0.001
M93133-1|AAA58435.1| 504|Homo sapiens cholesterol 7-alpha hydro... 44 0.001
BC112184-1|AAI12185.1| 504|Homo sapiens cytochrome P450, family... 44 0.001
BC101777-1|AAI01778.1| 504|Homo sapiens cytochrome P450, family... 44 0.001
AF176805-1|AAK11850.1| 506|Homo sapiens oxysterol 7alpha-hydrox... 44 0.002
AF127090-1|AAD20021.1| 506|Homo sapiens oxysterol 7alpha-hydrox... 44 0.002
AF029403-1|AAC95426.1| 506|Homo sapiens oxysterol 7alpha-hydrox... 43 0.002
BC029155-1|AAH29155.1| 489|Homo sapiens Unknown (protein for IM... 41 0.010
X58904-1|CAA41707.1| 371|Homo sapiens steroid 21-monooxygenase ... 40 0.023
X58902-1|CAA41706.1| 372|Homo sapiens steroid 21-monooxygenase ... 40 0.023
X58900-1|CAA41704.1| 372|Homo sapiens steroid 21-monooxygenase ... 40 0.023
X58899-1|CAA41703.1| 368|Homo sapiens steroid 21-monooxygenase ... 40 0.023
X58898-1|CAA41702.1| 371|Homo sapiens steroid 21-monooxygenase ... 40 0.023
AF280111-1|AAG33012.1| 250|Homo sapiens cytochrome P450 subfami... 36 0.37
BC109056-1|AAI09057.1| 320|Homo sapiens CYP2F1 protein protein. 36 0.49
AF144566-1|AAD30164.1| 339|Homo sapiens cytochrome P450 epoxyge... 36 0.49
M29873-1|AAA52143.1| 377|Homo sapiens CYP2B protein. 35 0.86
BC041174-1|AAH41174.1| 377|Homo sapiens CYP2B7P1 protein protein. 35 0.86
BC041839-1|AAH41839.1| 51|Homo sapiens CYP4V2 protein protein. 34 1.1
M17398-1|AAA35740.1| 393|Homo sapiens protein ( Human cytochrom... 33 2.0
AB209749-1|BAD92986.1| 210|Homo sapiens cytochrome P450, family... 33 2.6
S77409-1|AAB34643.1| 228|Homo sapiens steroid 18-hydroxylase pr... 32 4.6
S77873-1|AAD14267.1| 68|Homo sapiens CYP2E1 protein. 31 8.0
>BC060857-1|AAH60857.1| 525|Homo sapiens cytochrome P450, family 4,
subfamily V, polypeptide 2 protein.
Length = 525
Score = 226 bits (553), Expect = 1e-58
Identities = 107/230 (46%), Positives = 157/230 (68%), Gaps = 3/230 (1%)
Query: 322 QKKRLAFLDLLLE-SSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+ KR AFLDLLL + G +S E+I+E+VDT MFEGHDTTAA ++ L ++G + ++Q
Sbjct: 293 KNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQ 352
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
KV ELD +FG SDRP T +D +++YLE + ETLRL+P VP+ AR V+++ + G
Sbjct: 353 KKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVA--G 410
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
++ GT VI Y LHR P +PNP +F P+ F PE + RH YA+VPFSAGPR+C+G+
Sbjct: 411 YRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQ 470
Query: 501 KYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQPR 550
K+A+++ K ILS ILR+F + S+ K + L+ +IL+ + G ++L+ R
Sbjct: 471 KFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRR 520
Score = 167 bits (405), Expect = 1e-40
Identities = 79/204 (38%), Positives = 120/204 (58%), Gaps = 2/204 (0%)
Query: 71 DIFRNIVQKSADYDHESVVKIWIGPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKPWL 130
+ F+ I++ + +Y H ++K+W+GP +V LY+ +VEVIL+S IDK+ Y+F +PWL
Sbjct: 72 EFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWL 131
Query: 131 GNGLLISTGQKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASN--FDCHDY 188
G GLL STG KWRS RK++ PTFH +L+ F+D+ N + +V KL+K + F+C Y
Sbjct: 132 GLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEAFNCFFY 191
Query: 189 MSECTVEILLETAMGVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYA 248
++ C ++I+ ETAMG + Q EY AV +M +++ R WL DL +
Sbjct: 192 ITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEG 251
Query: 249 KNQTKLLDIIHGLTKKVIKRKKEE 272
K L I+H T VI + E
Sbjct: 252 WEHKKSLKILHTFTNSVIAERANE 275
>AY422002-1|AAR31180.1| 525|Homo sapiens cytochrome P450 4V2
protein.
Length = 525
Score = 226 bits (553), Expect = 1e-58
Identities = 107/230 (46%), Positives = 157/230 (68%), Gaps = 3/230 (1%)
Query: 322 QKKRLAFLDLLLE-SSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+ KR AFLDLLL + G +S E+I+E+VDT MFEGHDTTAA ++ L ++G + ++Q
Sbjct: 293 KNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQ 352
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
KV ELD +FG SDRP T +D +++YLE + ETLRL+P VP+ AR V+++ + G
Sbjct: 353 KKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVA--G 410
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
++ GT VI Y LHR P +PNP +F P+ F PE + RH YA+VPFSAGPR+C+G+
Sbjct: 411 YRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQ 470
Query: 501 KYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQPR 550
K+A+++ K ILS ILR+F + S+ K + L+ +IL+ + G ++L+ R
Sbjct: 471 KFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRR 520
Score = 167 bits (405), Expect = 1e-40
Identities = 79/204 (38%), Positives = 120/204 (58%), Gaps = 2/204 (0%)
Query: 71 DIFRNIVQKSADYDHESVVKIWIGPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKPWL 130
+ F+ I++ + +Y H ++K+W+GP +V LY+ +VEVIL+S IDK+ Y+F +PWL
Sbjct: 72 EFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWL 131
Query: 131 GNGLLISTGQKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASN--FDCHDY 188
G GLL STG KWRS RK++ PTFH +L+ F+D+ N + +V KL+K + F+C Y
Sbjct: 132 GLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEAFNCFFY 191
Query: 189 MSECTVEILLETAMGVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYA 248
++ C ++I+ ETAMG + Q EY AV +M +++ R WL DL +
Sbjct: 192 ITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEG 251
Query: 249 KNQTKLLDIIHGLTKKVIKRKKEE 272
K L I+H T VI + E
Sbjct: 252 WEHKKSLKILHTFTNSVIAERANE 275
>AK126473-1|BAC86562.1| 503|Homo sapiens protein ( Homo sapiens
cDNA FLJ44509 fis, clone UTERU3001585, weakly similar
to Cytochrome P450 4c3 (EC 1.14.-.-). ).
Length = 503
Score = 226 bits (553), Expect = 1e-58
Identities = 107/230 (46%), Positives = 157/230 (68%), Gaps = 3/230 (1%)
Query: 322 QKKRLAFLDLLLE-SSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+ KR AFLDLLL + G +S E+I+E+VDT MFEGHDTTAA ++ L ++G + ++Q
Sbjct: 271 KNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQ 330
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
KV ELD +FG SDRP T +D +++YLE + ETLRL+P VP+ AR V+++ + G
Sbjct: 331 KKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVA--G 388
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
++ GT VI Y LHR P +PNP +F P+ F PE + RH YA+VPFSAGPR+C+G+
Sbjct: 389 YRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQ 448
Query: 501 KYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQPR 550
K+A+++ K ILS ILR+F + S+ K + L+ +IL+ + G ++L+ R
Sbjct: 449 KFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRR 498
Score = 167 bits (405), Expect = 1e-40
Identities = 79/204 (38%), Positives = 120/204 (58%), Gaps = 2/204 (0%)
Query: 71 DIFRNIVQKSADYDHESVVKIWIGPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKPWL 130
+ F+ I++ + +Y H ++K+W+GP +V LY+ +VEVIL+S IDK+ Y+F +PWL
Sbjct: 50 EFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWL 109
Query: 131 GNGLLISTGQKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASN--FDCHDY 188
G GLL STG KWRS RK++ PTFH +L+ F+D+ N + +V KL+K + F+C Y
Sbjct: 110 GLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEAFNCFFY 169
Query: 189 MSECTVEILLETAMGVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYA 248
++ C ++I+ ETAMG + Q EY AV +M +++ R WL DL +
Sbjct: 170 ITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEG 229
Query: 249 KNQTKLLDIIHGLTKKVIKRKKEE 272
K L I+H T VI + E
Sbjct: 230 WEHKKSLKILHTFTNSVIAERANE 253
>AK122600-1|BAC85487.1| 525|Homo sapiens protein ( Homo sapiens
cDNA FLJ16007 fis, clone KIDNE2006580, weakly similar
to CYTOCHROME P450 4C1 (EC 1.14.14.1). ).
Length = 525
Score = 226 bits (553), Expect = 1e-58
Identities = 107/230 (46%), Positives = 157/230 (68%), Gaps = 3/230 (1%)
Query: 322 QKKRLAFLDLLLE-SSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+ KR AFLDLLL + G +S E+I+E+VDT MFEGHDTTAA ++ L ++G + ++Q
Sbjct: 293 KNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQ 352
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
KV ELD +FG SDRP T +D +++YLE + ETLRL+P VP+ AR V+++ + G
Sbjct: 353 KKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVA--G 410
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
++ GT VI Y LHR P +PNP +F P+ F PE + RH YA+VPFSAGPR+C+G+
Sbjct: 411 YRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQ 470
Query: 501 KYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQPR 550
K+A+++ K ILS ILR+F + S+ K + L+ +IL+ + G ++L+ R
Sbjct: 471 KFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRR 520
Score = 167 bits (405), Expect = 1e-40
Identities = 79/204 (38%), Positives = 120/204 (58%), Gaps = 2/204 (0%)
Query: 71 DIFRNIVQKSADYDHESVVKIWIGPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKPWL 130
+ F+ I++ + +Y H ++K+W+GP +V LY+ +VEVIL+S IDK+ Y+F +PWL
Sbjct: 72 EFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWL 131
Query: 131 GNGLLISTGQKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASN--FDCHDY 188
G GLL STG KWRS RK++ PTFH +L+ F+D+ N + +V KL+K + F+C Y
Sbjct: 132 GLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEAFNCFFY 191
Query: 189 MSECTVEILLETAMGVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYA 248
++ C ++I+ ETAMG + Q EY AV +M +++ R WL DL +
Sbjct: 192 ITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEG 251
Query: 249 KNQTKLLDIIHGLTKKVIKRKKEE 272
K L I+H T VI + E
Sbjct: 252 WEHKKSLKILHTFTNSVIAERANE 275
>D26480-1|BAA05490.1| 520|Homo sapiens leukotriene B4
omega-hydroxylase protein.
Length = 520
Score = 189 bits (461), Expect = 2e-47
Identities = 90/230 (39%), Positives = 146/230 (63%), Gaps = 5/230 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+ K L F+D LLL + G +SDE+I+ + DT MFEGHDTTA+G S+ L + H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351
Query: 381 DKVIEELDQIFGDSD-RPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSN 439
++ +E+ ++ D + + + + D + +L C+ E+LRL+PPVP+I+R V Q+I LP +
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLP-D 410
Query: 440 GKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVG 499
G+ IP G +I+ + H P V+P+P +DP F PE R AF+PFSAGPR+C+G
Sbjct: 411 GRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIG 470
Query: 500 RKYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ +AM ++KV+L+ L FRV+ D E + + +++L+ G +R++P
Sbjct: 471 QTFAMAEMKVVLALTLLRFRVLPDHTEP--RRKPELVLRAEGGLWLRVEP 518
Score = 100 bits (239), Expect = 2e-20
Identities = 54/193 (27%), Positives = 100/193 (51%), Gaps = 8/193 (4%)
Query: 90 KIWIGP-RLLVFLYDPRDVEVILSSHVYIDKAEE--YRFFKPWLGNGLLISTGQKWRSHR 146
K+W+GP L+ L P + ++++ I ++ Y F +PWLG+GLL+S G KW HR
Sbjct: 89 KVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHR 148
Query: 147 KLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASN----FDCHDYMSECTVEILLETAM 202
+++ P FH N+LK ++ +FN + + K + AS D +++S T++ L +
Sbjct: 149 RMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVF 208
Query: 203 GVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLT 262
Q++ EY A++++ ++ RH +I L D L+ T + + ++H T
Sbjct: 209 SFDSHCQEKPS-EYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFT 267
Query: 263 KKVIKRKKEEFAS 275
VI+ ++ S
Sbjct: 268 DAVIQERRRTLPS 280
>BC067439-1|AAH67439.1| 520|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 2 protein.
Length = 520
Score = 189 bits (461), Expect = 2e-47
Identities = 90/230 (39%), Positives = 146/230 (63%), Gaps = 5/230 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+ K L F+D LLL + G +SDE+I+ + DT MFEGHDTTA+G S+ L + H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351
Query: 381 DKVIEELDQIFGDSD-RPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSN 439
++ +E+ ++ D + + + + D + +L C+ E+LRL+PPVP+I+R V Q+I LP +
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLP-D 410
Query: 440 GKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVG 499
G+ IP G +I+ + H P V+P+P +DP F PE R AF+PFSAGPR+C+G
Sbjct: 411 GRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIG 470
Query: 500 RKYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ +AM ++KV+L+ L FRV+ D E + + +++L+ G +R++P
Sbjct: 471 QTFAMAEMKVVLALTLLRFRVLPDHTEP--RRKPELVLRAEGGLWLRVEP 518
Score = 100 bits (239), Expect = 2e-20
Identities = 54/193 (27%), Positives = 100/193 (51%), Gaps = 8/193 (4%)
Query: 90 KIWIGP-RLLVFLYDPRDVEVILSSHVYIDKAEE--YRFFKPWLGNGLLISTGQKWRSHR 146
K+W+GP L+ L P + ++++ I ++ Y F +PWLG+GLL+S G KW HR
Sbjct: 89 KVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHR 148
Query: 147 KLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASN----FDCHDYMSECTVEILLETAM 202
+++ P FH N+LK ++ +FN + + K + AS D +++S T++ L +
Sbjct: 149 RMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVF 208
Query: 203 GVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLT 262
Q++ EY A++++ ++ RH +I L D L+ T + + ++H T
Sbjct: 209 SFDSHCQEKPS-EYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFT 267
Query: 263 KKVIKRKKEEFAS 275
VI+ ++ S
Sbjct: 268 DAVIQERRRTLPS 280
>BC067437-1|AAH67437.1| 520|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 2 protein.
Length = 520
Score = 189 bits (461), Expect = 2e-47
Identities = 90/230 (39%), Positives = 146/230 (63%), Gaps = 5/230 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+ K L F+D LLL + G +SDE+I+ + DT MFEGHDTTA+G S+ L + H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351
Query: 381 DKVIEELDQIFGDSD-RPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSN 439
++ +E+ ++ D + + + + D + +L C+ E+LRL+PPVP+I+R V Q+I LP +
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLP-D 410
Query: 440 GKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVG 499
G+ IP G +I+ + H P V+P+P +DP F PE R AF+PFSAGPR+C+G
Sbjct: 411 GRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIG 470
Query: 500 RKYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ +AM ++KV+L+ L FRV+ D E + + +++L+ G +R++P
Sbjct: 471 QTFAMAEMKVVLALTLLRFRVLPDHTEP--RRKPELVLRAEGGLWLRVEP 518
Score = 100 bits (239), Expect = 2e-20
Identities = 54/193 (27%), Positives = 100/193 (51%), Gaps = 8/193 (4%)
Query: 90 KIWIGP-RLLVFLYDPRDVEVILSSHVYIDKAEE--YRFFKPWLGNGLLISTGQKWRSHR 146
K+W+GP L+ L P + ++++ I ++ Y F +PWLG+GLL+S G KW HR
Sbjct: 89 KVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHR 148
Query: 147 KLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASN----FDCHDYMSECTVEILLETAM 202
+++ P FH N+LK ++ +FN + + K + AS D +++S T++ L +
Sbjct: 149 RMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVF 208
Query: 203 GVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLT 262
Q++ EY A++++ ++ RH +I L D L+ T + + ++H T
Sbjct: 209 SFDSHCQEKPS-EYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFT 267
Query: 263 KKVIKRKKEEFAS 275
VI+ ++ S
Sbjct: 268 DAVIQERRRTLPS 280
>AF467894-1|AAL67578.1| 520|Homo sapiens cytochrome P450, subfamily
IVF, polypeptide 2 protein.
Length = 520
Score = 189 bits (461), Expect = 2e-47
Identities = 90/230 (39%), Positives = 146/230 (63%), Gaps = 5/230 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+ K L F+D LLL + G +SDE+I+ + DT MFEGHDTTA+G S+ L + H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351
Query: 381 DKVIEELDQIFGDSD-RPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSN 439
++ +E+ ++ D + + + + D + +L C+ E+LRL+PPVP+I+R V Q+I LP +
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLP-D 410
Query: 440 GKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVG 499
G+ IP G +I+ + H P V+P+P +DP F PE R AF+PFSAGPR+C+G
Sbjct: 411 GRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIG 470
Query: 500 RKYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ +AM ++KV+L+ L FRV+ D E + + +++L+ G +R++P
Sbjct: 471 QTFAMAEMKVVLALTLLRFRVLPDHTEP--RRKPELVLRAEGGLWLRVEP 518
Score = 100 bits (239), Expect = 2e-20
Identities = 54/193 (27%), Positives = 100/193 (51%), Gaps = 8/193 (4%)
Query: 90 KIWIGP-RLLVFLYDPRDVEVILSSHVYIDKAEE--YRFFKPWLGNGLLISTGQKWRSHR 146
K+W+GP L+ L P + ++++ I ++ Y F +PWLG+GLL+S G KW HR
Sbjct: 89 KVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHR 148
Query: 147 KLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASN----FDCHDYMSECTVEILLETAM 202
+++ P FH N+LK ++ +FN + + K + AS D +++S T++ L +
Sbjct: 149 RMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVF 208
Query: 203 GVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLT 262
Q++ EY A++++ ++ RH +I L D L+ T + + ++H T
Sbjct: 209 SFDSHCQEKPS-EYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFT 267
Query: 263 KKVIKRKKEEFAS 275
VI+ ++ S
Sbjct: 268 DAVIQERRRTLPS 280
>AC005336-1|AAC27730.1| 520|Homo sapiens CYP4F2 protein.
Length = 520
Score = 189 bits (461), Expect = 2e-47
Identities = 90/230 (39%), Positives = 146/230 (63%), Gaps = 5/230 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+ K L F+D LLL + G +SDE+I+ + DT MFEGHDTTA+G S+ L + H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351
Query: 381 DKVIEELDQIFGDSD-RPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSN 439
++ +E+ ++ D + + + + D + +L C+ E+LRL+PPVP+I+R V Q+I LP +
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLP-D 410
Query: 440 GKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVG 499
G+ IP G +I+ + H P V+P+P +DP F PE R AF+PFSAGPR+C+G
Sbjct: 411 GRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIG 470
Query: 500 RKYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ +AM ++KV+L+ L FRV+ D E + + +++L+ G +R++P
Sbjct: 471 QTFAMAEMKVVLALTLLRFRVLPDHTEP--RRKPELVLRAEGGLWLRVEP 518
Score = 100 bits (239), Expect = 2e-20
Identities = 54/193 (27%), Positives = 100/193 (51%), Gaps = 8/193 (4%)
Query: 90 KIWIGP-RLLVFLYDPRDVEVILSSHVYIDKAEE--YRFFKPWLGNGLLISTGQKWRSHR 146
K+W+GP L+ L P + ++++ I ++ Y F +PWLG+GLL+S G KW HR
Sbjct: 89 KVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHR 148
Query: 147 KLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASN----FDCHDYMSECTVEILLETAM 202
+++ P FH N+LK ++ +FN + + K + AS D +++S T++ L +
Sbjct: 149 RMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVF 208
Query: 203 GVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLT 262
Q++ EY A++++ ++ RH +I L D L+ T + + ++H T
Sbjct: 209 SFDSHCQEKPS-EYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFT 267
Query: 263 KKVIKRKKEEFAS 275
VI+ ++ S
Sbjct: 268 DAVIQERRRTLPS 280
>BC067440-1|AAH67440.1| 520|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 2 protein.
Length = 520
Score = 188 bits (458), Expect = 4e-47
Identities = 89/230 (38%), Positives = 146/230 (63%), Gaps = 5/230 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+ K L F+D LLL + G +SDE+I+ + DT MFEGHDTTA+G S+ L + H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351
Query: 381 DKVIEELDQIFGDSD-RPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSN 439
++ +E+ ++ D + + + + D + +L C+ E+LRL+PPVP+I+R V Q+I LP +
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLP-D 410
Query: 440 GKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVG 499
G+ IP G +I+ + H P ++P+P +DP F PE R AF+PFSAGPR+C+G
Sbjct: 411 GRVIPKGIICLISVFGTHHNPAMWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIG 470
Query: 500 RKYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ +AM ++KV+L+ L FRV+ D E + + +++L+ G +R++P
Sbjct: 471 QTFAMAEMKVVLALTLLRFRVLPDHTEP--RRKPELVLRAEGGLWLRVEP 518
Score = 99 bits (238), Expect = 2e-20
Identities = 54/193 (27%), Positives = 100/193 (51%), Gaps = 8/193 (4%)
Query: 90 KIWIGP-RLLVFLYDPRDVEVILSSHVYIDKAEE--YRFFKPWLGNGLLISTGQKWRSHR 146
K+W+GP L+ L P + ++++ I ++ Y F +PWLG+GLL+S G KW HR
Sbjct: 89 KVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHR 148
Query: 147 KLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASN----FDCHDYMSECTVEILLETAM 202
+++ P FH N+LK ++ +FN + + K + AS D +++S T++ L +
Sbjct: 149 RMLTPAFHFNILKPYMKIFNDSVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVF 208
Query: 203 GVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLT 262
Q++ EY A++++ ++ RH +I L D L+ T + + ++H T
Sbjct: 209 SFDSHCQEKPS-EYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFT 267
Query: 263 KKVIKRKKEEFAS 275
VI+ ++ S
Sbjct: 268 DAVIQERRRTLPS 280
>AB015306-1|BAA75823.1| 520|Homo sapiens Leukotriene B4
omega-hydroxylase protein.
Length = 520
Score = 188 bits (458), Expect = 4e-47
Identities = 89/230 (38%), Positives = 146/230 (63%), Gaps = 5/230 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+ K L F+D LLL + G +SDE+I+ + DT MFEGHDTTA+G S+ L + H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351
Query: 381 DKVIEELDQIFGDSD-RPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSN 439
++ +E+ ++ D + + + + D + +L C+ E+LRL+PPVP+I+R V Q+I LP +
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLP-D 410
Query: 440 GKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVG 499
G+ IP G +I+ + H P ++P+P +DP F PE R AF+PFSAGPR+C+G
Sbjct: 411 GRVIPKGIICLISVFGTHHNPAMWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIG 470
Query: 500 RKYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ +AM ++KV+L+ L FRV+ D E + + +++L+ G +R++P
Sbjct: 471 QTFAMAEMKVVLALTLLRFRVLPDHTEP--RRKPELVLRAEGGLWLRVEP 518
Score = 100 bits (239), Expect = 2e-20
Identities = 54/193 (27%), Positives = 100/193 (51%), Gaps = 8/193 (4%)
Query: 90 KIWIGP-RLLVFLYDPRDVEVILSSHVYIDKAEE--YRFFKPWLGNGLLISTGQKWRSHR 146
K+W+GP L+ L P + ++++ I ++ Y F +PWLG+GLL+S G KW HR
Sbjct: 89 KVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHR 148
Query: 147 KLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASN----FDCHDYMSECTVEILLETAM 202
+++ P FH N+LK ++ +FN + + K + AS D +++S T++ L +
Sbjct: 149 RMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVF 208
Query: 203 GVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLT 262
Q++ EY A++++ ++ RH +I L D L+ T + + ++H T
Sbjct: 209 SFDSHCQEKPS-EYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFT 267
Query: 263 KKVIKRKKEEFAS 275
VI+ ++ S
Sbjct: 268 DAVIQERRRTLPS 280
>BC035350-1|AAH35350.1| 524|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 12 protein.
Length = 524
Score = 188 bits (457), Expect = 6e-47
Identities = 92/230 (40%), Positives = 146/230 (63%), Gaps = 5/230 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+ K L F+D LLL + G A+SDE+I+ + DT MF GHDTTA+G S+ L + H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQ 351
Query: 381 DKVIEELDQIFGDSD-RPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSN 439
++ +E+ ++ D D + + + D ++ +L C+ E+LRL+PP P I+R Q+I LP +
Sbjct: 352 ERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLP-D 410
Query: 440 GKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVG 499
G+ IP G T +I +H P V+P+P +DP F PE S R AF+PFSAGPR+C+G
Sbjct: 411 GRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIG 470
Query: 500 RKYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ +AM ++KV+L+ +L +FR + D E KL ++I++ G +R++P
Sbjct: 471 QAFAMAEMKVVLALMLLHFRFLPDHTEPRRKL--ELIMRAEGGLWLRVEP 518
Score = 99.5 bits (237), Expect = 3e-20
Identities = 57/204 (27%), Positives = 102/204 (50%), Gaps = 10/204 (4%)
Query: 74 RNIVQKSADYDHESVVKIWIGPRL-LVFLYDPRDVEVILSSHVYIDKAEEY--RFFKPWL 130
++ Q SA Y V W+GP + + L P + I ++ I + RF KPWL
Sbjct: 75 KDSTQMSATYSQGFTV--WLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWL 132
Query: 131 GNGLLISTGQKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDK---LKKEASN-FDCH 186
G G+L+S G KW HR+++ P FH N+LKS+I +FN ++ ++DK L E S+ D
Sbjct: 133 GEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSCLDMF 192
Query: 187 DYMSECTVEILLETAMGVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTD 246
+++S T++ L + Q++ EY ++++ ++ R I D L+ +
Sbjct: 193 EHISLMTLDSLQKCIFSFDSHCQERPS-EYIATILELSALVEKRSQHILQHMDFLYYLSH 251
Query: 247 YAKNQTKLLDIIHGLTKKVIKRKK 270
+ + ++H T VI+ ++
Sbjct: 252 DGRRFHRACRLVHDFTDAVIRERR 275
>AY358977-1|AAQ89336.1| 524|Homo sapiens CYP4F12 protein.
Length = 524
Score = 188 bits (457), Expect = 6e-47
Identities = 92/230 (40%), Positives = 146/230 (63%), Gaps = 5/230 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+ K L F+D LLL + G A+SDE+I+ + DT MF GHDTTA+G S+ L + H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQ 351
Query: 381 DKVIEELDQIFGDSD-RPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSN 439
++ +E+ ++ D D + + + D ++ +L C+ E+LRL+PP P I+R Q+I LP +
Sbjct: 352 ERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLP-D 410
Query: 440 GKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVG 499
G+ IP G T +I +H P V+P+P +DP F PE S R AF+PFSAGPR+C+G
Sbjct: 411 GRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIG 470
Query: 500 RKYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ +AM ++KV+L+ +L +FR + D E KL ++I++ G +R++P
Sbjct: 471 QAFAMAEMKVVLALMLLHFRFLPDHTEPRRKL--ELIMRAEGGLWLRVEP 518
Score = 99.5 bits (237), Expect = 3e-20
Identities = 57/204 (27%), Positives = 102/204 (50%), Gaps = 10/204 (4%)
Query: 74 RNIVQKSADYDHESVVKIWIGPRL-LVFLYDPRDVEVILSSHVYIDKAEEY--RFFKPWL 130
++ Q SA Y V W+GP + + L P + I ++ I + RF KPWL
Sbjct: 75 KDSTQMSATYSQGFTV--WLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWL 132
Query: 131 GNGLLISTGQKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDK---LKKE-ASNFDCH 186
G G+L+S G KW HR+++ P FH N+LKS+I +FN ++ ++DK L E +S D
Sbjct: 133 GEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMF 192
Query: 187 DYMSECTVEILLETAMGVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTD 246
+++S T++ L + Q++ EY ++++ ++ R I D L+ +
Sbjct: 193 EHISLMTLDSLQKCIFSFDSHCQERPS-EYIATILELSALVEKRSQHILQHMDFLYYLSH 251
Query: 247 YAKNQTKLLDIIHGLTKKVIKRKK 270
+ + ++H T VI+ ++
Sbjct: 252 DGRRFHRACRLVHDFTDAVIRERR 275
>AY008841-1|AAG33247.1| 524|Homo sapiens cytochrome P450 isoform
4F12 protein.
Length = 524
Score = 188 bits (457), Expect = 6e-47
Identities = 92/230 (40%), Positives = 146/230 (63%), Gaps = 5/230 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+ K L F+D LLL + G A+SDE+I+ + DT MF GHDTTA+G S+ L + H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQ 351
Query: 381 DKVIEELDQIFGDSD-RPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSN 439
++ +E+ ++ D D + + + D ++ +L C+ E+LRL+PP P I+R Q+I LP +
Sbjct: 352 ERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLP-D 410
Query: 440 GKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVG 499
G+ IP G T +I +H P V+P+P +DP F PE S R AF+PFSAGPR+C+G
Sbjct: 411 GRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIG 470
Query: 500 RKYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ +AM ++KV+L+ +L +FR + D E KL ++I++ G +R++P
Sbjct: 471 QAFAMAEMKVVLALMLLHFRFLPDHTEPRRKL--ELIMRAEGGLWLRVEP 518
Score = 99.5 bits (237), Expect = 3e-20
Identities = 57/204 (27%), Positives = 102/204 (50%), Gaps = 10/204 (4%)
Query: 74 RNIVQKSADYDHESVVKIWIGPRL-LVFLYDPRDVEVILSSHVYIDKAEEY--RFFKPWL 130
++ Q SA Y V W+GP + + L P + I ++ I + RF KPWL
Sbjct: 75 KDSTQMSATYSQGFTV--WLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWL 132
Query: 131 GNGLLISTGQKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDK---LKKE-ASNFDCH 186
G G+L+S G KW HR+++ P FH N+LKS+I +FN ++ ++DK L E +S D
Sbjct: 133 GEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMF 192
Query: 187 DYMSECTVEILLETAMGVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTD 246
+++S T++ L + Q++ EY ++++ ++ R I D L+ +
Sbjct: 193 EHISLMTLDSLQKCIFSFDSHCQERPS-EYIATILELSALVEKRSQHILQHMDFLYYLSH 251
Query: 247 YAKNQTKLLDIIHGLTKKVIKRKK 270
+ + ++H T VI+ ++
Sbjct: 252 DGRRFHRACRLVHDFTDAVIRERR 275
>AC004523-1|AAC11543.1| 458|Homo sapiens F22329_1 protein.
Length = 458
Score = 188 bits (457), Expect = 6e-47
Identities = 92/230 (40%), Positives = 146/230 (63%), Gaps = 5/230 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+ K L F+D LLL + G A+SDE+I+ + DT MF GHDTTA+G S+ L + H + Q
Sbjct: 226 KSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQ 285
Query: 381 DKVIEELDQIFGDSD-RPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSN 439
++ +E+ ++ D D + + + D ++ +L C+ E+LRL+PP P I+R Q+I LP +
Sbjct: 286 ERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLP-D 344
Query: 440 GKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVG 499
G+ IP G T +I +H P V+P+P +DP F PE S R AF+PFSAGPR+C+G
Sbjct: 345 GRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIG 404
Query: 500 RKYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ +AM ++KV+L+ +L +FR + D E KL ++I++ G +R++P
Sbjct: 405 QAFAMAEMKVVLALMLLHFRFLPDHTEPRRKL--ELIMRAEGGLWLRVEP 452
Score = 101 bits (242), Expect = 7e-21
Identities = 58/204 (28%), Positives = 102/204 (50%), Gaps = 10/204 (4%)
Query: 74 RNIVQKSADYDHESVVKIWIGPRL-LVFLYDPRDVEVILSSHVYIDKAEEY--RFFKPWL 130
+N Q SA Y IW+GP + + L P + I ++ I + RF KPWL
Sbjct: 9 KNSTQMSATYSQGFT--IWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWL 66
Query: 131 GNGLLISTGQKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDK---LKKEASN-FDCH 186
G G+L+S G KW HR+++ P FH N+LKS+I +FN ++ ++DK L E S+ D
Sbjct: 67 GEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSCLDMF 126
Query: 187 DYMSECTVEILLETAMGVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTD 246
+++S T++ L + Q++ EY ++++ ++ R I D L+ +
Sbjct: 127 EHISLMTLDSLQKCIFSFDSHCQERPS-EYIATILELSALVEKRSQHILQHMDFLYYLSH 185
Query: 247 YAKNQTKLLDIIHGLTKKVIKRKK 270
+ + ++H T VI+ ++
Sbjct: 186 DGRRFHRACRLVHDFTDAVIRERR 209
>AB035131-1|BAB18270.1| 524|Homo sapiens cytochrome P450 protein.
Length = 524
Score = 188 bits (457), Expect = 6e-47
Identities = 92/230 (40%), Positives = 146/230 (63%), Gaps = 5/230 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+ K L F+D LLL + G A+SDE+I+ + DT MF GHDTTA+G S+ L + H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQ 351
Query: 381 DKVIEELDQIFGDSD-RPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSN 439
++ +E+ ++ D D + + + D ++ +L C+ E+LRL+PP P I+R Q+I LP +
Sbjct: 352 ERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLP-D 410
Query: 440 GKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVG 499
G+ IP G T +I +H P V+P+P +DP F PE S R AF+PFSAGPR+C+G
Sbjct: 411 GRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIG 470
Query: 500 RKYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ +AM ++KV+L+ +L +FR + D E KL ++I++ G +R++P
Sbjct: 471 QAFAMAEMKVVLALMLLHFRFLPDHTEPRRKL--ELIMRAEGGLWLRVEP 518
Score = 99.5 bits (237), Expect = 3e-20
Identities = 57/204 (27%), Positives = 102/204 (50%), Gaps = 10/204 (4%)
Query: 74 RNIVQKSADYDHESVVKIWIGPRL-LVFLYDPRDVEVILSSHVYIDKAEEY--RFFKPWL 130
++ Q SA Y V W+GP + + L P + I ++ I + RF KPWL
Sbjct: 75 KDSTQMSATYSQGFTV--WLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWL 132
Query: 131 GNGLLISTGQKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDK---LKKE-ASNFDCH 186
G G+L+S G KW HR+++ P FH N+LKS+I +FN ++ ++DK L E +S D
Sbjct: 133 GEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMF 192
Query: 187 DYMSECTVEILLETAMGVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTD 246
+++S T++ L + Q++ EY ++++ ++ R I D L+ +
Sbjct: 193 EHISLMTLDSLQKCIFSFDSHCQERPS-EYIATILELSALVEKRSQHILQHMDFLYYLSH 251
Query: 247 YAKNQTKLLDIIHGLTKKVIKRKK 270
+ + ++H T VI+ ++
Sbjct: 252 DGRRFHRACRLVHDFTDAVIRERR 275
>AB035130-1|BAB18269.1| 524|Homo sapiens cytochrome P450 protein.
Length = 524
Score = 188 bits (457), Expect = 6e-47
Identities = 92/230 (40%), Positives = 146/230 (63%), Gaps = 5/230 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+ K L F+D LLL + G A+SDE+I+ + DT MF GHDTTA+G S+ L + H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQ 351
Query: 381 DKVIEELDQIFGDSD-RPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSN 439
++ +E+ ++ D D + + + D ++ +L C+ E+LRL+PP P I+R Q+I LP +
Sbjct: 352 ERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLP-D 410
Query: 440 GKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVG 499
G+ IP G T +I +H P V+P+P +DP F PE S R AF+PFSAGPR+C+G
Sbjct: 411 GRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIG 470
Query: 500 RKYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ +AM ++KV+L+ +L +FR + D E KL ++I++ G +R++P
Sbjct: 471 QAFAMAEMKVVLALMLLHFRFLPDHTEPRRKL--ELIMRAEGGLWLRVEP 518
Score = 99.5 bits (237), Expect = 3e-20
Identities = 57/204 (27%), Positives = 102/204 (50%), Gaps = 10/204 (4%)
Query: 74 RNIVQKSADYDHESVVKIWIGPRL-LVFLYDPRDVEVILSSHVYIDKAEEY--RFFKPWL 130
++ Q SA Y V W+GP + + L P + I ++ I + RF KPWL
Sbjct: 75 KDSTQMSATYSQGFTV--WLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWL 132
Query: 131 GNGLLISTGQKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDK---LKKE-ASNFDCH 186
G G+L+S G KW HR+++ P FH N+LKS+I +FN ++ ++DK L E +S D
Sbjct: 133 GEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMF 192
Query: 187 DYMSECTVEILLETAMGVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTD 246
+++S T++ L + Q++ EY ++++ ++ R I D L+ +
Sbjct: 193 EHISLMTLDSLQKCIFSFDSHCQERPS-EYIATILELSALVEKRSQHILQHMDFLYYLSH 251
Query: 247 YAKNQTKLLDIIHGLTKKVIKRKK 270
+ + ++H T VI+ ++
Sbjct: 252 DGRRFHRACRLVHDFTDAVIRERR 275
>AF133298-1|AAD49566.1| 520|Homo sapiens cytochrome P450 protein.
Length = 520
Score = 186 bits (453), Expect = 2e-46
Identities = 87/230 (37%), Positives = 145/230 (63%), Gaps = 5/230 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+ K L F+D LLL ++G +SDE+I+ + DT MF GHDTTA+G S+ L + H + Q
Sbjct: 292 KSKTLDFIDVLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQ 351
Query: 381 DKVIEELDQIFGDSD-RPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSN 439
++ +E+ ++ D + + + + D ++ +L CL E+LRL+PP+P AR Q++ LP +
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDS 411
Query: 440 GKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVG 499
+ IP G I + +H P V+P+P +DP F PE + R AF+PFSAGPR+C+G
Sbjct: 412 -RVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIG 470
Query: 500 RKYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+K+AM ++KV+L+ L FR++ D +E + +I+L+ +G +R++P
Sbjct: 471 QKFAMAEMKVVLALTLLRFRILPDHREP--RRTPEIVLRAEDGLWLRVEP 518
Score = 97.5 bits (232), Expect = 1e-19
Identities = 74/260 (28%), Positives = 126/260 (48%), Gaps = 18/260 (6%)
Query: 25 LVPAVILW-YAYWRMSRR-RLYELADKLNXXXXXXXXXNALEFVGGSADIFRNIVQKSAD 82
L+ ++ W YA++ RR R + K N L V + + R + Q A
Sbjct: 30 LLARILAWTYAFYHNGRRLRCFPQPRKQNWFLGH------LGLVTPTEEGLRVLTQLVAT 83
Query: 83 YDHESVVKIWIGPRL-LVFLYDPRDVE-VILSSHVYIDK-AEEYRFFKPWLGNGLLISTG 139
Y + V+ W+GP ++ L P V VI +S DK Y+ KPWLG+GLL+S G
Sbjct: 84 YP-QGFVR-WLGPITPIINLCHPDIVRSVINTSDAITDKDIVFYKTLKPWLGDGLLLSVG 141
Query: 140 QKWRSHRKLIAPTFHLNVLKSFIDLFNANS---RAVVDKLKKEASN-FDCHDYMSECTVE 195
KWR HR+L+ P FH N+LK +I +F+ ++ A +L E S D +++S T++
Sbjct: 142 DKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGSTCLDVFEHISLMTLD 201
Query: 196 ILLETAMGVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLL 255
L + + Q++ EY A+M++ ++ R+ + + D L+ T + +
Sbjct: 202 SLQKCIFSFDSNCQEKPS-EYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHRAC 260
Query: 256 DIIHGLTKKVIKRKKEEFAS 275
++H T VI+ ++ S
Sbjct: 261 RLVHDFTDAVIQERRRTLTS 280
>U02388-1|AAC50052.2| 520|Homo sapiens cytochrome P450 4F2 protein.
Length = 520
Score = 184 bits (449), Expect = 6e-46
Identities = 88/230 (38%), Positives = 145/230 (63%), Gaps = 5/230 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+ K L F+D LLL + G +SDE+I+ + DT MFEGHDTTA+ S+ L + H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASVLSWVLYHLAKHPEYQ 351
Query: 381 DKVIEELDQIFGDSD-RPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSN 439
++ +E+ ++ D + + + + D + +L C+ E+LR++PPVP+I+R V Q+I LP +
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRVHPPVPVISRHVTQDIVLP-D 410
Query: 440 GKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVG 499
G+ IP G +I+ + H P V+P+P +DP F PE R AF+PFSAGPR+C+G
Sbjct: 411 GRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIG 470
Query: 500 RKYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ +AM ++KV+L+ L FRV+ D E + + +++L+ G +R++P
Sbjct: 471 QTFAMAEMKVVLALTLLRFRVLPDHTEP--RRKPELVLRAEGGLWLRVEP 518
Score = 100 bits (239), Expect = 2e-20
Identities = 54/193 (27%), Positives = 100/193 (51%), Gaps = 8/193 (4%)
Query: 90 KIWIGP-RLLVFLYDPRDVEVILSSHVYIDKAEE--YRFFKPWLGNGLLISTGQKWRSHR 146
K+W+GP L+ L P + ++++ I ++ Y F +PWLG+GLL+S G KW HR
Sbjct: 89 KVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHR 148
Query: 147 KLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASN----FDCHDYMSECTVEILLETAM 202
+++ P FH N+LK ++ +FN + + K + AS D +++S T++ L +
Sbjct: 149 RMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVF 208
Query: 203 GVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLT 262
Q++ EY A++++ ++ RH +I L D L+ T + + ++H T
Sbjct: 209 SFDSHCQEKPS-EYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFT 267
Query: 263 KKVIKRKKEEFAS 275
VI+ ++ S
Sbjct: 268 DAVIQERRRTLPS 280
>AY792513-1|AAV40834.1| 520|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 3 protein.
Length = 520
Score = 183 bits (445), Expect = 2e-45
Identities = 87/230 (37%), Positives = 144/230 (62%), Gaps = 5/230 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+ K L F+D LLL + G +SDE+I+ + DT MFEGHDTTA+G S+ L + H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351
Query: 381 DKVIEELDQIFGDSD-RPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSN 439
++ +E+ ++ D + + + + D ++ +L C+ E+LRL+PPVP ++R Q+I LP +
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLP-D 410
Query: 440 GKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVG 499
G+ IP G +I+ + H P V+P+P +DP F P+ R AF+PFSAGPR+C+G
Sbjct: 411 GRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIG 470
Query: 500 RKYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ +AM ++KV+L L FRV+ D E + + +++L+ G +R++P
Sbjct: 471 QAFAMAEMKVVLGLTLLRFRVLPDHTEP--RRKPELVLRAEGGLWLRVEP 518
Score = 101 bits (243), Expect = 5e-21
Identities = 55/191 (28%), Positives = 100/191 (52%), Gaps = 8/191 (4%)
Query: 92 WIGP-RLLVFLYDPRDVEVILSSHVYIDKAEE--YRFFKPWLGNGLLISTGQKWRSHRKL 148
W+GP +V ++ P ++ +L + I ++ Y F KPWLG+GLL+S G+KW HR++
Sbjct: 91 WVGPWHAIVRIFHPTYIKPVLFAPAAIVPKDKVFYSFLKPWLGDGLLLSAGEKWSRHRRM 150
Query: 149 IAPTFHLNVLKSFIDLFNANSRAVVDK---LKKEAS-NFDCHDYMSECTVEILLETAMGV 204
+ P FH N+LK ++ +FN + + K L E S D +++S T++ L +
Sbjct: 151 LTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSARLDMFEHISLMTLDSLQKCVFSF 210
Query: 205 SKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTKK 264
Q++ EY A++++ ++ RH +I L D L+ T + + ++H T
Sbjct: 211 DSHCQEKPS-EYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFRRACRLVHDFTDA 269
Query: 265 VIKRKKEEFAS 275
VI+ ++ S
Sbjct: 270 VIQERRRTLPS 280
>AF054821-1|AAC08589.1| 520|Homo sapiens cytochrome P-450 protein.
Length = 520
Score = 183 bits (445), Expect = 2e-45
Identities = 87/230 (37%), Positives = 144/230 (62%), Gaps = 5/230 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+ K L F+D LLL + G +SDE+I+ + DT MFEGHDTTA+G S+ L + H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351
Query: 381 DKVIEELDQIFGDSD-RPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSN 439
++ +E+ ++ D + + + + D ++ +L C+ E+LRL+PPVP ++R Q+I LP +
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLP-D 410
Query: 440 GKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVG 499
G+ IP G +I+ + H P V+P+P +DP F P+ R AF+PFSAGPR+C+G
Sbjct: 411 GRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIG 470
Query: 500 RKYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ +AM ++KV+L L FRV+ D E + + +++L+ G +R++P
Sbjct: 471 QAFAMAEMKVVLGLTLLRFRVLPDHTEP--RRKPELVLRAEGGIWLRVEP 518
Score = 101 bits (242), Expect = 7e-21
Identities = 54/193 (27%), Positives = 100/193 (51%), Gaps = 8/193 (4%)
Query: 90 KIWIGPRLLVFLY-DPRDVEVILSSHVYIDKAEE--YRFFKPWLGNGLLISTGQKWRSHR 146
K+W+GP V + P + ++++ I ++ Y F KPWLG+GLL+S G+KW HR
Sbjct: 89 KVWMGPIFPVIRFCHPNIIRSVINASAAIVPKDKVFYSFLKPWLGDGLLLSAGEKWSRHR 148
Query: 147 KLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEAS----NFDCHDYMSECTVEILLETAM 202
+++ P FH N+LK ++ +FN + + K + AS D +++S T++ L +
Sbjct: 149 RMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASKGYARLDMFEHISLMTLDSLQKCVF 208
Query: 203 GVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLT 262
Q++ EY A++++ ++ RH +I L D L+ T + + ++H T
Sbjct: 209 SFDSHCQEKPS-EYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFRRACRLVHDFT 267
Query: 263 KKVIKRKKEEFAS 275
VI+ ++ S
Sbjct: 268 DAVIQERRRTLPS 280
>X16699-1|CAA34672.1| 511|Homo sapiens protein ( Human mRNA for
cytochrome P-450HP. ).
Length = 511
Score = 182 bits (444), Expect = 2e-45
Identities = 88/228 (38%), Positives = 143/228 (62%), Gaps = 4/228 (1%)
Query: 323 KKRLAFLDLLLES-SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQD 381
++ L FLD+LL + + + +SD +++ +VDT MFEGHDTT +G S+FL M ++ + Q
Sbjct: 280 RRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQH 339
Query: 382 KVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGK 441
+ EE+ +I GD D + D +M YL C+ E+ RLYPPVP + RQ+++ +T +G+
Sbjct: 340 RCREEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFV-DGR 397
Query: 442 KIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRK 501
+PAG+ + + Y LHR V+P+P FD F E ++ RH +AF+PFSAGPR+C+G++
Sbjct: 398 SLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQ 457
Query: 502 YAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+AM ++KV+ + L F D K+ ++L+ GF + L+P
Sbjct: 458 FAMSEMKVVTAMCLLRFEFSLDPSRLPIKM-PQLVLRSKNGFHLHLKP 504
Score = 83.8 bits (198), Expect = 1e-15
Identities = 48/185 (25%), Positives = 88/185 (47%), Gaps = 7/185 (3%)
Query: 91 IWIGPRL-LVFLYDPRDVEVILSSHVYIDKAEE-YRFFKPWLGNGLLISTGQKWRSHRKL 148
+W G + + +Y+P + + S KA + Y FF W+G GLL+ G KW HRKL
Sbjct: 83 LWFGQFIGFLNIYEPDYAKAVYSRGD--PKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKL 140
Query: 149 IAPTFHLNVLKSFIDLFNANSRAVVDKLK---KEASNFDCHDYMSECTVEILLETAMGVS 205
+ P FH +VLK ++ +F ++R ++DK + +E +FD + + L++ G
Sbjct: 141 LTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRG 200
Query: 206 KSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTKKV 265
+ Y +AV + ++ R D ++ T + + + + H T +V
Sbjct: 201 DTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQV 260
Query: 266 IKRKK 270
I+ +K
Sbjct: 261 IRERK 265
>J02871-1|AAA35712.1| 511|Homo sapiens protein ( Human lung
cytochrome P450 (IV subfamily) BI protein, complete cds.
).
Length = 511
Score = 182 bits (444), Expect = 2e-45
Identities = 88/228 (38%), Positives = 143/228 (62%), Gaps = 4/228 (1%)
Query: 323 KKRLAFLDLLLES-SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQD 381
++ L FLD+LL + + + +SD +++ +VDT MFEGHDTT +G S+FL M ++ + Q
Sbjct: 280 RRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQH 339
Query: 382 KVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGK 441
+ EE+ +I GD D + D +M YL C+ E+ RLYPPVP + RQ+++ +T +G+
Sbjct: 340 RCREEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFV-DGR 397
Query: 442 KIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRK 501
+PAG+ + + Y LHR V+P+P FD F E ++ RH +AF+PFSAGPR+C+G++
Sbjct: 398 SLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQ 457
Query: 502 YAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+AM ++KV+ + L F D K+ ++L+ GF + L+P
Sbjct: 458 FAMSEMKVVTAMCLLRFEFSLDPSRLPIKM-PQLVLRSKNGFHLHLKP 504
Score = 84.2 bits (199), Expect = 1e-15
Identities = 65/264 (24%), Positives = 119/264 (45%), Gaps = 14/264 (5%)
Query: 14 TFSAINLFYVLLVPAV-ILWYAYWRMSRRRLYELADKLNXXXXXXXXXNALEFVG-GSAD 71
+FS++ L+ L+ + L + + RR L + DK +ALE GS D
Sbjct: 9 SFSSLGLWASGLILVLGFLKLIHLLLRRRTLAKAMDKFPGPPTHWLFGHALEIQETGSLD 68
Query: 72 IFRNIVQKSADYDHESVVKIWIGPRL-LVFLYDPRDVEVILSSHVYIDKAEE-YRFFKPW 129
+V + + + +W G + + +Y+P + + S KA + Y FF W
Sbjct: 69 ---KVVSWAHQFPYAH--PLWFGQFIGFLNIYEPDYAKAVYSRGD--PKAPDVYDFFLQW 121
Query: 130 LGNGLLISTGQKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLK---KEASNFDCH 186
+G GLL+ G KW HRKL+ P FH +VLK ++ +F ++R ++DK + +E +FD
Sbjct: 122 IGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIF 181
Query: 187 DYMSECTVEILLETAMGVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTD 246
+ + L++ G + Y +AV + ++ R D ++ T
Sbjct: 182 CDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTP 241
Query: 247 YAKNQTKLLDIIHGLTKKVIKRKK 270
+ + + + H T +VI+ +K
Sbjct: 242 HGRRFLRACQVAHDHTDQVIRERK 265
>DQ518907-1|ABF47106.1| 511|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 511
Score = 182 bits (444), Expect = 2e-45
Identities = 88/228 (38%), Positives = 143/228 (62%), Gaps = 4/228 (1%)
Query: 323 KKRLAFLDLLLES-SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQD 381
++ L FLD+LL + + + +SD +++ +VDT MFEGHDTT +G S+FL M ++ + Q
Sbjct: 280 RRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQH 339
Query: 382 KVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGK 441
+ EE+ +I GD D + D +M YL C+ E+ RLYPPVP + RQ+++ +T +G+
Sbjct: 340 RCREEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFV-DGR 397
Query: 442 KIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRK 501
+PAG+ + + Y LHR V+P+P FD F E ++ RH +AF+PFSAGPR+C+G++
Sbjct: 398 SLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQ 457
Query: 502 YAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+AM ++KV+ + L F D K+ ++L+ GF + L+P
Sbjct: 458 FAMSEMKVVTAMCLLRFEFSLDPSRLPIKM-PQLVLRSKNGFHLHLKP 504
Score = 83.8 bits (198), Expect = 1e-15
Identities = 48/185 (25%), Positives = 88/185 (47%), Gaps = 7/185 (3%)
Query: 91 IWIGPRL-LVFLYDPRDVEVILSSHVYIDKAEE-YRFFKPWLGNGLLISTGQKWRSHRKL 148
+W G + + +Y+P + + S KA + Y FF W+G GLL+ G KW HRKL
Sbjct: 83 LWFGQFIGFLNIYEPDYAKAVYSRGD--PKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKL 140
Query: 149 IAPTFHLNVLKSFIDLFNANSRAVVDKLK---KEASNFDCHDYMSECTVEILLETAMGVS 205
+ P FH +VLK ++ +F ++R ++DK + +E +FD + + L++ G
Sbjct: 141 LTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRG 200
Query: 206 KSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTKKV 265
+ Y +AV + ++ R D ++ T + + + + H T +V
Sbjct: 201 DTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQV 260
Query: 266 IKRKK 270
I+ +K
Sbjct: 261 IRERK 265
>BC017758-1|AAH17758.1| 512|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 512
Score = 182 bits (444), Expect = 2e-45
Identities = 88/228 (38%), Positives = 143/228 (62%), Gaps = 4/228 (1%)
Query: 323 KKRLAFLDLLLES-SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQD 381
++ L FLD+LL + + + +SD +++ +VDT MFEGHDTT +G S+FL M ++ + Q
Sbjct: 281 RRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQH 340
Query: 382 KVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGK 441
+ EE+ +I GD D + D +M YL C+ E+ RLYPPVP + RQ+++ +T +G+
Sbjct: 341 RCREEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFV-DGR 398
Query: 442 KIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRK 501
+PAG+ + + Y LHR V+P+P FD F E ++ RH +AF+PFSAGPR+C+G++
Sbjct: 399 SLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQ 458
Query: 502 YAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+AM ++KV+ + L F D K+ ++L+ GF + L+P
Sbjct: 459 FAMSEMKVVTAMCLLRFEFSLDPSRLPIKM-PQLVLRSKNGFHLHLKP 505
Score = 81.4 bits (192), Expect = 8e-15
Identities = 49/186 (26%), Positives = 89/186 (47%), Gaps = 8/186 (4%)
Query: 91 IWIGPRL-LVFLYDPRDVEVILSSHVYIDKAEE-YRFFKPWLGNGLLISTGQKWRSHRKL 148
+W G + + +Y+P + + S KA + Y FF W+G GLL+ G KW HRKL
Sbjct: 83 LWFGQFIGFLNIYEPDYAKAVYSRGD--PKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKL 140
Query: 149 IAPTFHLNVLKSFIDLFNANSRAVVDKLK---KEASNFDCHDYMSECTVEILLETAMGVS 205
+ P FH +VLK ++ +F ++R ++DK + +E +FD + + L++ G
Sbjct: 141 LTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRG 200
Query: 206 KSTQDQS-GFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTKK 264
+ S Y +AV + ++ R D ++ T + + + + H T +
Sbjct: 201 DTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQ 260
Query: 265 VIKRKK 270
VI+ +K
Sbjct: 261 VIRERK 266
>AY151049-1|AAN72312.1| 497|Homo sapiens pulmonary cytochrome P450
4B1 variant protein.
Length = 497
Score = 182 bits (444), Expect = 2e-45
Identities = 88/228 (38%), Positives = 143/228 (62%), Gaps = 4/228 (1%)
Query: 323 KKRLAFLDLLLES-SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQD 381
++ L FLD+LL + + + +SD +++ +VDT MFEGHDTT +G S+FL M ++ + Q
Sbjct: 266 RRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQH 325
Query: 382 KVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGK 441
+ EE+ +I GD D + D +M YL C+ E+ RLYPPVP + RQ+++ +T +G+
Sbjct: 326 RCREEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFV-DGR 383
Query: 442 KIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRK 501
+PAG+ + + Y LHR V+P+P FD F E ++ RH +AF+PFSAGPR+C+G++
Sbjct: 384 SLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQ 443
Query: 502 YAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+AM ++KV+ + L F D K+ ++L+ GF + L+P
Sbjct: 444 FAMSEMKVVTAMCLLRFEFSLDPSRLPIKM-PQLVLRSKNGFHLHLKP 490
Score = 69.3 bits (162), Expect = 3e-11
Identities = 38/144 (26%), Positives = 69/144 (47%), Gaps = 4/144 (2%)
Query: 131 GNGLLISTGQKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLK---KEASNFDCHD 187
G GLL+ G KW HRKL+ P FH +VLK ++ +F ++R ++DK + +E +FD
Sbjct: 108 GRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFC 167
Query: 188 YMSECTVEILLETAMGVSKSTQDQS-GFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTD 246
+ + L++ G + S Y +AV + ++ R D ++ T
Sbjct: 168 DVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTP 227
Query: 247 YAKNQTKLLDIIHGLTKKVIKRKK 270
+ + + + H T +VI+ +K
Sbjct: 228 HGRRFLRACQVAHDHTDQVIRERK 251
>AY151048-1|AAN72311.1| 512|Homo sapiens pulmonary cytochrome P450
4B1 protein.
Length = 512
Score = 182 bits (444), Expect = 2e-45
Identities = 88/228 (38%), Positives = 143/228 (62%), Gaps = 4/228 (1%)
Query: 323 KKRLAFLDLLLES-SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQD 381
++ L FLD+LL + + + +SD +++ +VDT MFEGHDTT +G S+FL M ++ + Q
Sbjct: 281 RRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQH 340
Query: 382 KVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGK 441
+ EE+ +I GD D + D +M YL C+ E+ RLYPPVP + RQ+++ +T +G+
Sbjct: 341 RCREEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFV-DGR 398
Query: 442 KIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRK 501
+PAG+ + + Y LHR V+P+P FD F E ++ RH +AF+PFSAGPR+C+G++
Sbjct: 399 SLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQ 458
Query: 502 YAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+AM ++KV+ + L F D K+ ++L+ GF + L+P
Sbjct: 459 FAMSEMKVVTAMCLLRFEFSLDPSRLPIKM-PQLVLRSKNGFHLHLKP 505
Score = 81.4 bits (192), Expect = 8e-15
Identities = 49/186 (26%), Positives = 89/186 (47%), Gaps = 8/186 (4%)
Query: 91 IWIGPRL-LVFLYDPRDVEVILSSHVYIDKAEE-YRFFKPWLGNGLLISTGQKWRSHRKL 148
+W G + + +Y+P + + S KA + Y FF W+G GLL+ G KW HRKL
Sbjct: 83 LWFGQFIGFLNIYEPDYAKAVYSRGD--PKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKL 140
Query: 149 IAPTFHLNVLKSFIDLFNANSRAVVDKLK---KEASNFDCHDYMSECTVEILLETAMGVS 205
+ P FH +VLK ++ +F ++R ++DK + +E +FD + + L++ G
Sbjct: 141 LTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRG 200
Query: 206 KSTQDQS-GFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTKK 264
+ S Y +AV + ++ R D ++ T + + + + H T +
Sbjct: 201 DTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQ 260
Query: 265 VIKRKK 270
VI+ +K
Sbjct: 261 VIRERK 266
>AY064485-1|AAL57720.1| 511|Homo sapiens cytochrome P450 protein.
Length = 511
Score = 182 bits (444), Expect = 2e-45
Identities = 88/228 (38%), Positives = 143/228 (62%), Gaps = 4/228 (1%)
Query: 323 KKRLAFLDLLLES-SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQD 381
++ L FLD+LL + + + +SD +++ +VDT MFEGHDTT +G S+FL M ++ + Q
Sbjct: 280 RRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQH 339
Query: 382 KVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGK 441
+ EE+ +I GD D + D +M YL C+ E+ RLYPPVP + RQ+++ +T +G+
Sbjct: 340 RCREEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFV-DGR 397
Query: 442 KIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRK 501
+PAG+ + + Y LHR V+P+P FD F E ++ RH +AF+PFSAGPR+C+G++
Sbjct: 398 SLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQ 457
Query: 502 YAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+AM ++KV+ + L F D K+ ++L+ GF + L+P
Sbjct: 458 FAMSEMKVVTAMCLLRFEFSLDPSRLPIKM-PQLVLRSKNGFHLHLKP 504
Score = 83.4 bits (197), Expect = 2e-15
Identities = 48/185 (25%), Positives = 88/185 (47%), Gaps = 7/185 (3%)
Query: 91 IWIGPRL-LVFLYDPRDVEVILSSHVYIDKAEE-YRFFKPWLGNGLLISTGQKWRSHRKL 148
+W G + + +Y+P + + S KA + Y FF W+G GLL+ G KW HRKL
Sbjct: 83 LWFGQFIGFLNIYEPDYAKAVYSRGD--PKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKL 140
Query: 149 IAPTFHLNVLKSFIDLFNANSRAVVDKLKK---EASNFDCHDYMSECTVEILLETAMGVS 205
+ P FH +VLK ++ +F ++R ++DK ++ E +FD + + L++ G
Sbjct: 141 LTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAWEGKSFDIFCDVGHMALNTLMKCTFGRG 200
Query: 206 KSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTKKV 265
+ Y +AV + ++ R D ++ T + + + + H T +V
Sbjct: 201 DTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQV 260
Query: 266 IKRKK 270
I+ +K
Sbjct: 261 IRERK 265
>AL593856-7|CAI16983.1| 497|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 497
Score = 182 bits (444), Expect = 2e-45
Identities = 88/228 (38%), Positives = 143/228 (62%), Gaps = 4/228 (1%)
Query: 323 KKRLAFLDLLLES-SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQD 381
++ L FLD+LL + + + +SD +++ +VDT MFEGHDTT +G S+FL M ++ + Q
Sbjct: 266 RRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQH 325
Query: 382 KVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGK 441
+ EE+ +I GD D + D +M YL C+ E+ RLYPPVP + RQ+++ +T +G+
Sbjct: 326 RCREEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFV-DGR 383
Query: 442 KIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRK 501
+PAG+ + + Y LHR V+P+P FD F E ++ RH +AF+PFSAGPR+C+G++
Sbjct: 384 SLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQ 443
Query: 502 YAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+AM ++KV+ + L F D K+ ++L+ GF + L+P
Sbjct: 444 FAMSEMKVVTAMCLLRFEFSLDPSRLPIKM-PQLVLRSKNGFHLHLKP 490
Score = 69.3 bits (162), Expect = 3e-11
Identities = 38/144 (26%), Positives = 69/144 (47%), Gaps = 4/144 (2%)
Query: 131 GNGLLISTGQKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLK---KEASNFDCHD 187
G GLL+ G KW HRKL+ P FH +VLK ++ +F ++R ++DK + +E +FD
Sbjct: 108 GRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFC 167
Query: 188 YMSECTVEILLETAMGVSKSTQDQS-GFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTD 246
+ + L++ G + S Y +AV + ++ R D ++ T
Sbjct: 168 DVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTP 227
Query: 247 YAKNQTKLLDIIHGLTKKVIKRKK 270
+ + + + H T +VI+ +K
Sbjct: 228 HGRRFLRACQVAHDHTDQVIRERK 251
>AL593856-6|CAI16982.1| 512|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 512
Score = 182 bits (444), Expect = 2e-45
Identities = 88/228 (38%), Positives = 143/228 (62%), Gaps = 4/228 (1%)
Query: 323 KKRLAFLDLLLES-SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQD 381
++ L FLD+LL + + + +SD +++ +VDT MFEGHDTT +G S+FL M ++ + Q
Sbjct: 281 RRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQH 340
Query: 382 KVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGK 441
+ EE+ +I GD D + D +M YL C+ E+ RLYPPVP + RQ+++ +T +G+
Sbjct: 341 RCREEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFV-DGR 398
Query: 442 KIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRK 501
+PAG+ + + Y LHR V+P+P FD F E ++ RH +AF+PFSAGPR+C+G++
Sbjct: 399 SLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQ 458
Query: 502 YAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+AM ++KV+ + L F D K+ ++L+ GF + L+P
Sbjct: 459 FAMSEMKVVTAMCLLRFEFSLDPSRLPIKM-PQLVLRSKNGFHLHLKP 505
Score = 81.4 bits (192), Expect = 8e-15
Identities = 49/186 (26%), Positives = 89/186 (47%), Gaps = 8/186 (4%)
Query: 91 IWIGPRL-LVFLYDPRDVEVILSSHVYIDKAEE-YRFFKPWLGNGLLISTGQKWRSHRKL 148
+W G + + +Y+P + + S KA + Y FF W+G GLL+ G KW HRKL
Sbjct: 83 LWFGQFIGFLNIYEPDYAKAVYSRGD--PKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKL 140
Query: 149 IAPTFHLNVLKSFIDLFNANSRAVVDKLK---KEASNFDCHDYMSECTVEILLETAMGVS 205
+ P FH +VLK ++ +F ++R ++DK + +E +FD + + L++ G
Sbjct: 141 LTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRG 200
Query: 206 KSTQDQS-GFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTKK 264
+ S Y +AV + ++ R D ++ T + + + + H T +
Sbjct: 201 DTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQ 260
Query: 265 VIKRKK 270
VI+ +K
Sbjct: 261 VIRERK 266
>AL593856-5|CAI16981.1| 511|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 511
Score = 182 bits (444), Expect = 2e-45
Identities = 88/228 (38%), Positives = 143/228 (62%), Gaps = 4/228 (1%)
Query: 323 KKRLAFLDLLLES-SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQD 381
++ L FLD+LL + + + +SD +++ +VDT MFEGHDTT +G S+FL M ++ + Q
Sbjct: 280 RRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQH 339
Query: 382 KVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGK 441
+ EE+ +I GD D + D +M YL C+ E+ RLYPPVP + RQ+++ +T +G+
Sbjct: 340 RCREEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFV-DGR 397
Query: 442 KIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRK 501
+PAG+ + + Y LHR V+P+P FD F E ++ RH +AF+PFSAGPR+C+G++
Sbjct: 398 SLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQ 457
Query: 502 YAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+AM ++KV+ + L F D K+ ++L+ GF + L+P
Sbjct: 458 FAMSEMKVVTAMCLLRFEFSLDPSRLPIKM-PQLVLRSKNGFHLHLKP 504
Score = 83.8 bits (198), Expect = 1e-15
Identities = 48/185 (25%), Positives = 88/185 (47%), Gaps = 7/185 (3%)
Query: 91 IWIGPRL-LVFLYDPRDVEVILSSHVYIDKAEE-YRFFKPWLGNGLLISTGQKWRSHRKL 148
+W G + + +Y+P + + S KA + Y FF W+G GLL+ G KW HRKL
Sbjct: 83 LWFGQFIGFLNIYEPDYAKAVYSRGD--PKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKL 140
Query: 149 IAPTFHLNVLKSFIDLFNANSRAVVDKLK---KEASNFDCHDYMSECTVEILLETAMGVS 205
+ P FH +VLK ++ +F ++R ++DK + +E +FD + + L++ G
Sbjct: 141 LTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRG 200
Query: 206 KSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTKKV 265
+ Y +AV + ++ R D ++ T + + + + H T +V
Sbjct: 201 DTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQV 260
Query: 266 IKRKK 270
I+ +K
Sbjct: 261 IRERK 265
>AL356793-4|CAI22559.1| 511|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 511
Score = 182 bits (444), Expect = 2e-45
Identities = 88/228 (38%), Positives = 143/228 (62%), Gaps = 4/228 (1%)
Query: 323 KKRLAFLDLLLES-SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQD 381
++ L FLD+LL + + + +SD +++ +VDT MFEGHDTT +G S+FL M ++ + Q
Sbjct: 280 RRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQH 339
Query: 382 KVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGK 441
+ EE+ +I GD D + D +M YL C+ E+ RLYPPVP + RQ+++ +T +G+
Sbjct: 340 RCREEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFV-DGR 397
Query: 442 KIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRK 501
+PAG+ + + Y LHR V+P+P FD F E ++ RH +AF+PFSAGPR+C+G++
Sbjct: 398 SLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQ 457
Query: 502 YAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+AM ++KV+ + L F D K+ ++L+ GF + L+P
Sbjct: 458 FAMSEMKVVTAMCLLRFEFSLDPSRLPIKM-PQLVLRSKNGFHLHLKP 504
Score = 83.8 bits (198), Expect = 1e-15
Identities = 48/185 (25%), Positives = 88/185 (47%), Gaps = 7/185 (3%)
Query: 91 IWIGPRL-LVFLYDPRDVEVILSSHVYIDKAEE-YRFFKPWLGNGLLISTGQKWRSHRKL 148
+W G + + +Y+P + + S KA + Y FF W+G GLL+ G KW HRKL
Sbjct: 83 LWFGQFIGFLNIYEPDYAKAVYSRGD--PKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKL 140
Query: 149 IAPTFHLNVLKSFIDLFNANSRAVVDKLK---KEASNFDCHDYMSECTVEILLETAMGVS 205
+ P FH +VLK ++ +F ++R ++DK + +E +FD + + L++ G
Sbjct: 141 LTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRG 200
Query: 206 KSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTKKV 265
+ Y +AV + ++ R D ++ T + + + + H T +V
Sbjct: 201 DTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQV 260
Query: 266 IKRKK 270
I+ +K
Sbjct: 261 IRERK 265
>AL356793-3|CAI22557.1| 512|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 512
Score = 182 bits (444), Expect = 2e-45
Identities = 88/228 (38%), Positives = 143/228 (62%), Gaps = 4/228 (1%)
Query: 323 KKRLAFLDLLLES-SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQD 381
++ L FLD+LL + + + +SD +++ +VDT MFEGHDTT +G S+FL M ++ + Q
Sbjct: 281 RRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQH 340
Query: 382 KVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGK 441
+ EE+ +I GD D + D +M YL C+ E+ RLYPPVP + RQ+++ +T +G+
Sbjct: 341 RCREEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFV-DGR 398
Query: 442 KIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRK 501
+PAG+ + + Y LHR V+P+P FD F E ++ RH +AF+PFSAGPR+C+G++
Sbjct: 399 SLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQ 458
Query: 502 YAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+AM ++KV+ + L F D K+ ++L+ GF + L+P
Sbjct: 459 FAMSEMKVVTAMCLLRFEFSLDPSRLPIKM-PQLVLRSKNGFHLHLKP 505
Score = 81.4 bits (192), Expect = 8e-15
Identities = 49/186 (26%), Positives = 89/186 (47%), Gaps = 8/186 (4%)
Query: 91 IWIGPRL-LVFLYDPRDVEVILSSHVYIDKAEE-YRFFKPWLGNGLLISTGQKWRSHRKL 148
+W G + + +Y+P + + S KA + Y FF W+G GLL+ G KW HRKL
Sbjct: 83 LWFGQFIGFLNIYEPDYAKAVYSRGD--PKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKL 140
Query: 149 IAPTFHLNVLKSFIDLFNANSRAVVDKLK---KEASNFDCHDYMSECTVEILLETAMGVS 205
+ P FH +VLK ++ +F ++R ++DK + +E +FD + + L++ G
Sbjct: 141 LTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRG 200
Query: 206 KSTQDQS-GFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTKK 264
+ S Y +AV + ++ R D ++ T + + + + H T +
Sbjct: 201 DTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQ 260
Query: 265 VIKRKK 270
VI+ +K
Sbjct: 261 VIRERK 266
>AL356793-2|CAI22558.1| 497|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 497
Score = 182 bits (444), Expect = 2e-45
Identities = 88/228 (38%), Positives = 143/228 (62%), Gaps = 4/228 (1%)
Query: 323 KKRLAFLDLLLES-SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQD 381
++ L FLD+LL + + + +SD +++ +VDT MFEGHDTT +G S+FL M ++ + Q
Sbjct: 266 RRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQH 325
Query: 382 KVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGK 441
+ EE+ +I GD D + D +M YL C+ E+ RLYPPVP + RQ+++ +T +G+
Sbjct: 326 RCREEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFV-DGR 383
Query: 442 KIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRK 501
+PAG+ + + Y LHR V+P+P FD F E ++ RH +AF+PFSAGPR+C+G++
Sbjct: 384 SLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQ 443
Query: 502 YAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+AM ++KV+ + L F D K+ ++L+ GF + L+P
Sbjct: 444 FAMSEMKVVTAMCLLRFEFSLDPSRLPIKM-PQLVLRSKNGFHLHLKP 490
Score = 69.3 bits (162), Expect = 3e-11
Identities = 38/144 (26%), Positives = 69/144 (47%), Gaps = 4/144 (2%)
Query: 131 GNGLLISTGQKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLK---KEASNFDCHD 187
G GLL+ G KW HRKL+ P FH +VLK ++ +F ++R ++DK + +E +FD
Sbjct: 108 GRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFC 167
Query: 188 YMSECTVEILLETAMGVSKSTQDQS-GFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTD 246
+ + L++ G + S Y +AV + ++ R D ++ T
Sbjct: 168 DVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTP 227
Query: 247 YAKNQTKLLDIIHGLTKKVIKRKK 270
+ + + + H T +VI+ +K
Sbjct: 228 HGRRFLRACQVAHDHTDQVIRERK 251
>D12620-1|BAA02144.1| 520|Homo sapiens cytochrome P-450LTBV
protein.
Length = 520
Score = 182 bits (443), Expect = 3e-45
Identities = 87/230 (37%), Positives = 144/230 (62%), Gaps = 5/230 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+ K L F+D LLL + G +SDE+I+ + DT MFEGHDTTA+G S+ L + H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351
Query: 381 DKVIEELDQIFGDSD-RPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSN 439
++ +E+ ++ D + + + + D ++ +L C+ E+LRL+PPVP ++R Q+I LP +
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLP-D 410
Query: 440 GKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVG 499
G+ IP G +I+ + H P V+P+P +DP F P+ R AF+PFSAGPR+C+G
Sbjct: 411 GRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIG 470
Query: 500 RKYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ +AM ++KV+L L FRV+ D E + + +++L+ G +R++P
Sbjct: 471 QAFAMAEMKVVLGLTLLAFRVLPDHTEP--RRKPELVLRAEGGLWLRVEP 518
Score = 101 bits (243), Expect = 5e-21
Identities = 55/191 (28%), Positives = 100/191 (52%), Gaps = 8/191 (4%)
Query: 92 WIGP-RLLVFLYDPRDVEVILSSHVYIDKAEE--YRFFKPWLGNGLLISTGQKWRSHRKL 148
W+GP +V ++ P ++ +L + I ++ Y F KPWLG+GLL+S G+KW HR++
Sbjct: 91 WVGPWHAIVRIFHPTYIKPVLFAPAAIVPKDKVFYSFLKPWLGDGLLLSAGEKWSRHRRM 150
Query: 149 IAPTFHLNVLKSFIDLFNANSRAVVDK---LKKEAS-NFDCHDYMSECTVEILLETAMGV 204
+ P FH N+LK ++ +FN + + K L E S D +++S T++ L +
Sbjct: 151 LTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSARLDMFEHISLMTLDSLQKCVFSF 210
Query: 205 SKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTKK 264
Q++ EY A++++ ++ RH +I L D L+ T + + ++H T
Sbjct: 211 DSHCQEKPS-EYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFRRACRLVHDFTDD 269
Query: 265 VIKRKKEEFAS 275
VI+ ++ S
Sbjct: 270 VIQERRRTLPS 280
>AY064486-1|AAL57721.1| 511|Homo sapiens cytochrome P450 protein.
Length = 511
Score = 182 bits (443), Expect = 3e-45
Identities = 88/228 (38%), Positives = 142/228 (62%), Gaps = 4/228 (1%)
Query: 323 KKRLAFLDLLLES-SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQD 381
++ L FLD+LL + + + +SD +++ +VDT MFEGHDTT G S+FL M ++ + Q
Sbjct: 280 RRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTGGISWFLYCMALYPEHQH 339
Query: 382 KVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGK 441
+ EE+ +I GD D + D +M YL C+ E+ RLYPPVP + RQ+++ +T +G+
Sbjct: 340 RCREEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFV-DGR 397
Query: 442 KIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRK 501
+PAG+ + + Y LHR V+P+P FD F E ++ RH +AF+PFSAGPR+C+G++
Sbjct: 398 SLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQ 457
Query: 502 YAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+AM ++KV+ + L F D K+ ++L+ GF + L+P
Sbjct: 458 FAMSEMKVVTAMCLLRFEFSLDPSRLPIKM-PQLVLRSKNGFHLHLKP 504
Score = 83.8 bits (198), Expect = 1e-15
Identities = 48/185 (25%), Positives = 88/185 (47%), Gaps = 7/185 (3%)
Query: 91 IWIGPRL-LVFLYDPRDVEVILSSHVYIDKAEE-YRFFKPWLGNGLLISTGQKWRSHRKL 148
+W G + + +Y+P + + S KA + Y FF W+G GLL+ G KW HRKL
Sbjct: 83 LWFGQFIGFLNIYEPDYAKAVYSRGD--PKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKL 140
Query: 149 IAPTFHLNVLKSFIDLFNANSRAVVDKLK---KEASNFDCHDYMSECTVEILLETAMGVS 205
+ P FH +VLK ++ +F ++R ++DK + +E +FD + + L++ G
Sbjct: 141 LTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRG 200
Query: 206 KSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTKKV 265
+ Y +AV + ++ R D ++ T + + + + H T +V
Sbjct: 201 DTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQV 260
Query: 266 IKRKK 270
I+ +K
Sbjct: 261 IRERK 265
>AB002461-1|BAA25991.1| 520|Homo sapiens leukotriene B4
omega-hydroxylase protein.
Length = 520
Score = 182 bits (443), Expect = 3e-45
Identities = 87/230 (37%), Positives = 144/230 (62%), Gaps = 5/230 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+ K L F+D LLL + G +SDE+I+ + DT MFEGHDTTA+G S+ L + H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351
Query: 381 DKVIEELDQIFGDSD-RPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSN 439
++ +E+ ++ D + + + + D ++ +L C+ E+LRL+PPVP ++R Q+I LP +
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLP-D 410
Query: 440 GKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVG 499
G+ IP G +I+ + H P V+P+P +DP F P+ R AF+PFSAGPR+C+G
Sbjct: 411 GRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIG 470
Query: 500 RKYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ +AM ++KV+L L FRV+ D E + + +++L+ G +R++P
Sbjct: 471 QAFAMAEMKVVLGLTLLAFRVLPDHTEP--RRKPELVLRAEGGLWLRVEP 518
Score = 101 bits (243), Expect = 5e-21
Identities = 55/191 (28%), Positives = 100/191 (52%), Gaps = 8/191 (4%)
Query: 92 WIGP-RLLVFLYDPRDVEVILSSHVYIDKAEE--YRFFKPWLGNGLLISTGQKWRSHRKL 148
W+GP +V ++ P ++ +L + I ++ Y F KPWLG+GLL+S G+KW HR++
Sbjct: 91 WVGPWHAIVRIFHPTYIKPVLFAPAAIVPKDKVFYSFLKPWLGDGLLLSAGEKWSRHRRM 150
Query: 149 IAPTFHLNVLKSFIDLFNANSRAVVDK---LKKEAS-NFDCHDYMSECTVEILLETAMGV 204
+ P FH N+LK ++ +FN + + K L E S D +++S T++ L +
Sbjct: 151 LTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSARLDMFEHISLMTLDSLQKCVFSF 210
Query: 205 SKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTKK 264
Q++ EY A++++ ++ RH +I L D L+ T + + ++H T
Sbjct: 211 DSHCQEKPS-EYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFRRACRLVHDFTDD 269
Query: 265 VIKRKKEEFAS 275
VI+ ++ S
Sbjct: 270 VIQERRRTLPS 280
>AB002454-1|BAA25990.1| 520|Homo sapiens leukotriene B4
omega-hydroxylase protein.
Length = 520
Score = 182 bits (443), Expect = 3e-45
Identities = 87/230 (37%), Positives = 144/230 (62%), Gaps = 5/230 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+ K L F+D LLL + G +SDE+I+ + DT MFEGHDTTA+G S+ L + H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351
Query: 381 DKVIEELDQIFGDSD-RPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSN 439
++ +E+ ++ D + + + + D ++ +L C+ E+LRL+PPVP ++R Q+I LP +
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLP-D 410
Query: 440 GKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVG 499
G+ IP G +I+ + H P V+P+P +DP F P+ R AF+PFSAGPR+C+G
Sbjct: 411 GRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIG 470
Query: 500 RKYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ +AM ++KV+L L FRV+ D E + + +++L+ G +R++P
Sbjct: 471 QAFAMAEMKVVLGLTLLAFRVLPDHTEP--RRKPELVLRAEGGLWLRVEP 518
Score = 101 bits (243), Expect = 5e-21
Identities = 55/191 (28%), Positives = 100/191 (52%), Gaps = 8/191 (4%)
Query: 92 WIGP-RLLVFLYDPRDVEVILSSHVYIDKAEE--YRFFKPWLGNGLLISTGQKWRSHRKL 148
W+GP +V ++ P ++ +L + I ++ Y F KPWLG+GLL+S G+KW HR++
Sbjct: 91 WVGPWHAIVRIFHPTYIKPVLFAPAAIVPKDKVFYSFLKPWLGDGLLLSAGEKWSRHRRM 150
Query: 149 IAPTFHLNVLKSFIDLFNANSRAVVDK---LKKEAS-NFDCHDYMSECTVEILLETAMGV 204
+ P FH N+LK ++ +FN + + K L E S D +++S T++ L +
Sbjct: 151 LTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSARLDMFEHISLMTLDSLQKCVFSF 210
Query: 205 SKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTKK 264
Q++ EY A++++ ++ RH +I L D L+ T + + ++H T
Sbjct: 211 DSHCQEKPS-EYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFRRACRLVHDFTDD 269
Query: 265 VIKRKKEEFAS 275
VI+ ++ S
Sbjct: 270 VIQERRRTLPS 280
>S67580-1|AAB29502.1| 519|Homo sapiens fatty acid omega-hydroxylase
protein.
Length = 519
Score = 181 bits (440), Expect = 7e-45
Identities = 89/228 (39%), Positives = 140/228 (61%), Gaps = 6/228 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+K+ L FLD LLL ++G +SD++++ +VDT MFEGHDTTA+G S+ L + H Q
Sbjct: 285 RKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQ 344
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
++ EE+ + GD +T+ +M Y C+ E LRLYPPVP I R+++ +T P +G
Sbjct: 345 ERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFP-DG 402
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
+ +P G ++++ Y LH P V+PNP FDP F P + +H +AF+PFS G R+C+G+
Sbjct: 403 RSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPSRFAP--GSAQHSHAFLPFSGGSRNCIGK 460
Query: 501 KYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQ 548
++AM +LKV + L F ++ D + A ++LK G +RL+
Sbjct: 461 QFAMNELKVATALTLLRFELLPDPTRIPIPI-ARLVLKSKNGIHLRLR 507
Score = 87.0 bits (206), Expect = 2e-16
Identities = 51/186 (27%), Positives = 95/186 (51%), Gaps = 6/186 (3%)
Query: 92 WI-GPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKPWLGNGLLISTGQKWRSHRKLIA 150
W+ G ++ V LYDP ++VIL YRF PW+G GLL+ GQ W HR+++
Sbjct: 89 WLWGGKVRVQLYDPDYMKVILGRSDPKSHGS-YRFLAPWIGYGLLLLNGQTWFQHRRMLT 147
Query: 151 PTFHLNVLKSFIDLFNANSRAVVDK---LKKEASNFDCHDYMSECTVEILLETAMGVSKS 207
P FH ++LK ++ L + R ++DK L + S + ++S T++ +++ A S
Sbjct: 148 PAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGS 207
Query: 208 TQ-DQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTKKVI 266
Q D++ Y A+ + +++ R + + D ++ T + + + H T +VI
Sbjct: 208 IQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVI 267
Query: 267 KRKKEE 272
+ +K +
Sbjct: 268 QLRKAQ 273
>AF491285-1|AAM09532.1| 511|Homo sapiens cytochrome P450 protein.
Length = 511
Score = 181 bits (440), Expect = 7e-45
Identities = 87/228 (38%), Positives = 143/228 (62%), Gaps = 4/228 (1%)
Query: 323 KKRLAFLDLLLES-SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQD 381
++ L FLD+LL + + + +SD +++ +VDT MFEGHDTT +G S+FL + ++ + Q
Sbjct: 280 RRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCIALYPEHQH 339
Query: 382 KVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGK 441
+ EE+ +I GD D + D +M YL C+ E+ RLYPPVP + RQ+++ +T +G+
Sbjct: 340 RCREEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFV-DGR 397
Query: 442 KIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRK 501
+PAG+ + + Y LHR V+P+P FD F E ++ RH +AF+PFSAGPR+C+G++
Sbjct: 398 SLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQ 457
Query: 502 YAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+AM ++KV+ + L F D K+ ++L+ GF + L+P
Sbjct: 458 FAMSEMKVVTAMCLLRFEFSLDPSRLPIKM-PQLVLRSKNGFHLHLKP 504
Score = 83.8 bits (198), Expect = 1e-15
Identities = 48/185 (25%), Positives = 88/185 (47%), Gaps = 7/185 (3%)
Query: 91 IWIGPRL-LVFLYDPRDVEVILSSHVYIDKAEE-YRFFKPWLGNGLLISTGQKWRSHRKL 148
+W G + + +Y+P + + S KA + Y FF W+G GLL+ G KW HRKL
Sbjct: 83 LWFGQFIGFLNIYEPDYAKAVYSRGD--PKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKL 140
Query: 149 IAPTFHLNVLKSFIDLFNANSRAVVDKLK---KEASNFDCHDYMSECTVEILLETAMGVS 205
+ P FH +VLK ++ +F ++R ++DK + +E +FD + + L++ G
Sbjct: 141 LTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRG 200
Query: 206 KSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTKKV 265
+ Y +AV + ++ R D ++ T + + + + H T +V
Sbjct: 201 DTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQV 260
Query: 266 IKRKK 270
I+ +K
Sbjct: 261 IRERK 265
>AY280371-1|AAQ21367.1| 519|Homo sapiens cytochrome P450 4A22K
protein.
Length = 519
Score = 180 bits (439), Expect = 9e-45
Identities = 89/228 (39%), Positives = 141/228 (61%), Gaps = 6/228 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+K+ L FLD LLL ++G +SD++++ +VDT MFEGHDTTA+G S+ L + H Q
Sbjct: 285 RKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQ 344
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
++ EE+ + GD +T+ +M Y C+ E LRLYPPVP I R+++ +T P +G
Sbjct: 345 ERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFP-DG 402
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
+ +P G ++++ Y LH P V+PNP FDP F P + +H +AF+PFS G R+C+G+
Sbjct: 403 RSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAP--GSAQHSHAFLPFSGGSRNCIGK 460
Query: 501 KYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQ 548
++AM +LKV + L F ++ D + + A ++LK G +RL+
Sbjct: 461 QFAMNQLKVARALTLLRFELLPDPTRTPIPM-ARLVLKSKNGIHLRLR 507
Score = 85.0 bits (201), Expect = 6e-16
Identities = 51/191 (26%), Positives = 96/191 (50%), Gaps = 6/191 (3%)
Query: 87 SVVKIWI-GPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKPWLGNGLLISTGQKWRSH 145
S WI G ++ V LYDP ++VIL Y+F PW+G LL+ GQ W H
Sbjct: 84 SACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGS-YKFLAPWIGYSLLLLNGQTWFQH 142
Query: 146 RKLIAPTFHLNVLKSFIDLFNANSRAVVDK---LKKEASNFDCHDYMSECTVEILLETAM 202
R+++ P FH ++LK ++ L + R ++DK L + S + ++S T++ ++++A
Sbjct: 143 RRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEFFQHVSLMTLDTIMKSAF 202
Query: 203 GVSKSTQ-DQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGL 261
S Q D++ Y A+ + +++ R + + D ++ T + + + H
Sbjct: 203 SHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQH 262
Query: 262 TKKVIKRKKEE 272
T +VI+ +K +
Sbjct: 263 TDQVIQLRKAQ 273
>L04751-1|AAA58436.1| 519|Homo sapiens cytochrome P450 protein.
Length = 519
Score = 180 bits (437), Expect = 2e-44
Identities = 89/228 (39%), Positives = 140/228 (61%), Gaps = 6/228 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+K+ L FLD LLL ++G +SD++++ +VDT MFEGHDTTA+G S+ L + H Q
Sbjct: 285 RKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQ 344
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
++ EE+ + GD +T+ +M Y C+ E LRLYPPVP I R+++ +T P +G
Sbjct: 345 ERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFP-DG 402
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
+ +P G ++++ Y LH P V+PNP FDP F P + +H +AF+PFS G R+C+G+
Sbjct: 403 RSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAP--GSAQHSHAFLPFSGGSRNCIGK 460
Query: 501 KYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQ 548
++AM +LKV + L F ++ D + A ++LK G +RL+
Sbjct: 461 QFAMNELKVATALTLLRFELLPDPTRIPIPI-ARLVLKSKNGIHLRLR 507
Score = 87.0 bits (206), Expect = 2e-16
Identities = 51/186 (27%), Positives = 95/186 (51%), Gaps = 6/186 (3%)
Query: 92 WI-GPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKPWLGNGLLISTGQKWRSHRKLIA 150
W+ G ++ V LYDP ++VIL YRF PW+G GLL+ GQ W HR+++
Sbjct: 89 WLWGGKVRVQLYDPDYMKVILGRSDPKSHGS-YRFLAPWIGYGLLLLNGQTWFQHRRMLT 147
Query: 151 PTFHLNVLKSFIDLFNANSRAVVDK---LKKEASNFDCHDYMSECTVEILLETAMGVSKS 207
P FH ++LK ++ L + R ++DK L + S + ++S T++ +++ A S
Sbjct: 148 PAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGS 207
Query: 208 TQ-DQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTKKVI 266
Q D++ Y A+ + +++ R + + D ++ T + + + H T +VI
Sbjct: 208 IQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVI 267
Query: 267 KRKKEE 272
+ +K +
Sbjct: 268 QLRKAQ 273
>D26481-1|BAA05491.1| 519|Homo sapiens fatty acids
omega-hydroxylase protein.
Length = 519
Score = 180 bits (437), Expect = 2e-44
Identities = 89/228 (39%), Positives = 140/228 (61%), Gaps = 6/228 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+K+ L FLD LLL ++G +SD++++ +VDT MFEGHDTTA+G S+ L + H Q
Sbjct: 285 RKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQ 344
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
++ EE+ + GD +T+ +M Y C+ E LRLYPPVP I R+++ +T P +G
Sbjct: 345 ERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFP-DG 402
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
+ +P G ++++ Y LH P V+PNP FDP F P + +H +AF+PFS G R+C+G+
Sbjct: 403 RSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAP--GSAQHSHAFLPFSGGSRNCIGK 460
Query: 501 KYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQ 548
++AM +LKV + L F ++ D + A ++LK G +RL+
Sbjct: 461 QFAMNELKVATALTLLRFELLPDPTRIPIPI-ARLVLKSKNGIHLRLR 507
Score = 87.0 bits (206), Expect = 2e-16
Identities = 51/186 (27%), Positives = 95/186 (51%), Gaps = 6/186 (3%)
Query: 92 WI-GPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKPWLGNGLLISTGQKWRSHRKLIA 150
W+ G ++ V LYDP ++VIL YRF PW+G GLL+ GQ W HR+++
Sbjct: 89 WLWGGKVRVQLYDPDYMKVILGRSDPKSHGS-YRFLAPWIGYGLLLLNGQTWFQHRRMLT 147
Query: 151 PTFHLNVLKSFIDLFNANSRAVVDK---LKKEASNFDCHDYMSECTVEILLETAMGVSKS 207
P FH ++LK ++ L + R ++DK L + S + ++S T++ +++ A S
Sbjct: 148 PAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGS 207
Query: 208 TQ-DQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTKKVI 266
Q D++ Y A+ + +++ R + + D ++ T + + + H T +VI
Sbjct: 208 IQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVI 267
Query: 267 KRKKEE 272
+ +K +
Sbjct: 268 QLRKAQ 273
>AY369778-1|AAQ56847.1| 519|Homo sapiens cytochrome P450, family 4,
subfamily A, polypeptide 11 protein.
Length = 519
Score = 180 bits (437), Expect = 2e-44
Identities = 89/228 (39%), Positives = 140/228 (61%), Gaps = 6/228 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+K+ L FLD LLL ++G +SD++++ +VDT MFEGHDTTA+G S+ L + H Q
Sbjct: 285 RKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQ 344
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
++ EE+ + GD +T+ +M Y C+ E LRLYPPVP I R+++ +T P +G
Sbjct: 345 ERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFP-DG 402
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
+ +P G ++++ Y LH P V+PNP FDP F P + +H +AF+PFS G R+C+G+
Sbjct: 403 RSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAP--GSAQHSHAFLPFSGGSRNCIGK 460
Query: 501 KYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQ 548
++AM +LKV + L F ++ D + A ++LK G +RL+
Sbjct: 461 QFAMNELKVATALTLLRFELLPDPTRIPIPI-ARLVLKSKNGIHLRLR 507
Score = 87.0 bits (206), Expect = 2e-16
Identities = 51/186 (27%), Positives = 95/186 (51%), Gaps = 6/186 (3%)
Query: 92 WI-GPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKPWLGNGLLISTGQKWRSHRKLIA 150
W+ G ++ V LYDP ++VIL YRF PW+G GLL+ GQ W HR+++
Sbjct: 89 WLWGGKVRVQLYDPDYMKVILGRSDPKSHGS-YRFLAPWIGYGLLLLNGQTWFQHRRMLT 147
Query: 151 PTFHLNVLKSFIDLFNANSRAVVDK---LKKEASNFDCHDYMSECTVEILLETAMGVSKS 207
P FH ++LK ++ L + R ++DK L + S + ++S T++ +++ A S
Sbjct: 148 PAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGS 207
Query: 208 TQ-DQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTKKVI 266
Q D++ Y A+ + +++ R + + D ++ T + + + H T +VI
Sbjct: 208 IQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVI 267
Query: 267 KRKKEE 272
+ +K +
Sbjct: 268 QLRKAQ 273
>AY280372-1|AAQ21368.1| 519|Homo sapiens cytochrome P450 4A22
protein.
Length = 519
Score = 180 bits (437), Expect = 2e-44
Identities = 89/228 (39%), Positives = 140/228 (61%), Gaps = 6/228 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+K+ L FLD LLL ++G +SD++++ +VDT MFEGHDTTA+G S+ L + H Q
Sbjct: 285 RKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQ 344
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
++ EE+ + GD +T+ +M Y C+ E LRLYPPVP I R+++ +T P +G
Sbjct: 345 ERCREEIHGLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFP-DG 402
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
+ +P G ++++ Y LH P V+PNP FDP F P + +H +AF+PFS G R+C+G+
Sbjct: 403 RSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPSRFAP--GSAQHSHAFLPFSGGSRNCIGK 460
Query: 501 KYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQ 548
++AM +LKV + L F ++ D + A ++LK G +RL+
Sbjct: 461 QFAMNQLKVARALTLLRFELLPDPTRIPIPM-ARLVLKSKNGIHLRLR 507
Score = 86.2 bits (204), Expect = 3e-16
Identities = 51/191 (26%), Positives = 94/191 (49%), Gaps = 6/191 (3%)
Query: 87 SVVKIWI-GPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKPWLGNGLLISTGQKWRSH 145
S WI G ++ V LYDP ++VIL Y+F PW+G LL+ GQ W H
Sbjct: 84 SACPYWIWGGKVRVQLYDPDYMKVILGRSDSKSHGS-YKFLAPWIGYSLLLLNGQTWFQH 142
Query: 146 RKLIAPTFHLNVLKSFIDLFNANSRAVVDK---LKKEASNFDCHDYMSECTVEILLETAM 202
R+++ P FH ++LK ++ L + R ++DK L + S + ++S T++ ++++A
Sbjct: 143 RRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEFFQHVSLMTLDTIMKSAF 202
Query: 203 GVSKSTQ-DQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGL 261
S Q D++ Y A+ + ++ R + D ++ T + + + H
Sbjct: 203 SHQGSIQVDRNSQSYIQAISDLSSLVFCRMRNAFHENDAIYSLTSAGRWTHRACQLAHQH 262
Query: 262 TKKVIKRKKEE 272
T +VI+ +K +
Sbjct: 263 TDQVIQLRKAQ 273
>AL731892-3|CAH72778.1| 519|Homo sapiens cytochrome P450, family 4,
subfamily A, polypeptide 11 protein.
Length = 519
Score = 180 bits (437), Expect = 2e-44
Identities = 89/228 (39%), Positives = 140/228 (61%), Gaps = 6/228 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+K+ L FLD LLL ++G +SD++++ +VDT MFEGHDTTA+G S+ L + H Q
Sbjct: 285 RKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQ 344
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
++ EE+ + GD +T+ +M Y C+ E LRLYPPVP I R+++ +T P +G
Sbjct: 345 ERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFP-DG 402
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
+ +P G ++++ Y LH P V+PNP FDP F P + +H +AF+PFS G R+C+G+
Sbjct: 403 RSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAP--GSAQHSHAFLPFSGGSRNCIGK 460
Query: 501 KYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQ 548
++AM +LKV + L F ++ D + A ++LK G +RL+
Sbjct: 461 QFAMNELKVATALTLLRFELLPDPTRIPIPI-ARLVLKSKNGIHLRLR 507
Score = 87.0 bits (206), Expect = 2e-16
Identities = 51/186 (27%), Positives = 95/186 (51%), Gaps = 6/186 (3%)
Query: 92 WI-GPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKPWLGNGLLISTGQKWRSHRKLIA 150
W+ G ++ V LYDP ++VIL YRF PW+G GLL+ GQ W HR+++
Sbjct: 89 WLWGGKVRVQLYDPDYMKVILGRSDPKSHGS-YRFLAPWIGYGLLLLNGQTWFQHRRMLT 147
Query: 151 PTFHLNVLKSFIDLFNANSRAVVDK---LKKEASNFDCHDYMSECTVEILLETAMGVSKS 207
P FH ++LK ++ L + R ++DK L + S + ++S T++ +++ A S
Sbjct: 148 PAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGS 207
Query: 208 TQ-DQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTKKVI 266
Q D++ Y A+ + +++ R + + D ++ T + + + H T +VI
Sbjct: 208 IQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVI 267
Query: 267 KRKKEE 272
+ +K +
Sbjct: 268 QLRKAQ 273
>AF525488-1|AAO16078.1| 519|Homo sapiens cytochrome P450, subfamily
IVA, polypeptide 11 protein.
Length = 519
Score = 178 bits (433), Expect = 5e-44
Identities = 88/228 (38%), Positives = 140/228 (61%), Gaps = 6/228 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+K+ L FLD LLL ++G +SD++++ +VDT MFEGHDTTA+G S+ L + H Q
Sbjct: 285 RKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQ 344
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
++ EE+ + GD +T+ +M Y C+ E LRL+PPVP I R+++ +T P +G
Sbjct: 345 ERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLFPPVPGIGRELSTPVTFP-DG 402
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
+ +P G ++++ Y LH P V+PNP FDP F P + +H +AF+PFS G R+C+G+
Sbjct: 403 RSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAP--GSAQHSHAFLPFSGGSRNCIGK 460
Query: 501 KYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQ 548
++AM +LKV + L F ++ D + A ++LK G +RL+
Sbjct: 461 QFAMNELKVATALTLLRFELLPDPTRIPIPI-ARLVLKSKNGIHLRLR 507
Score = 87.0 bits (206), Expect = 2e-16
Identities = 51/186 (27%), Positives = 95/186 (51%), Gaps = 6/186 (3%)
Query: 92 WI-GPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKPWLGNGLLISTGQKWRSHRKLIA 150
W+ G ++ V LYDP ++VIL YRF PW+G GLL+ GQ W HR+++
Sbjct: 89 WLWGGKVRVQLYDPDYMKVILGRSDPKSHGS-YRFLAPWIGYGLLLLNGQTWFQHRRMLT 147
Query: 151 PTFHLNVLKSFIDLFNANSRAVVDK---LKKEASNFDCHDYMSECTVEILLETAMGVSKS 207
P FH ++LK ++ L + R ++DK L + S + ++S T++ +++ A S
Sbjct: 148 PAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGS 207
Query: 208 TQ-DQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTKKVI 266
Q D++ Y A+ + +++ R + + D ++ T + + + H T +VI
Sbjct: 208 IQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVI 267
Query: 267 KRKKEE 272
+ +K +
Sbjct: 268 QLRKAQ 273
>BC016853-1|AAH16853.1| 524|Homo sapiens CYP4F11 protein protein.
Length = 524
Score = 176 bits (428), Expect = 2e-43
Identities = 86/230 (37%), Positives = 142/230 (61%), Gaps = 5/230 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+ K L F+D LLL + G +SDE+I+ + DT MFEGHDTTA+G S+ L + H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351
Query: 381 DKVIEELDQIFGDSDR-PVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSN 439
++ +E+ ++ D + + + D ++ +L C+ E+LRL+PPVP+I+R Q+ LP +
Sbjct: 352 EQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLP-D 410
Query: 440 GKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVG 499
G+ IP G +I +H P V+P+P +DP F E R AF+PFSAGPR+C+G
Sbjct: 411 GRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFNQENIKERSPLAFIPFSAGPRNCIG 470
Query: 500 RKYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ +AM ++KV+L+ L +FR++ E + + ++IL+ G +R++P
Sbjct: 471 QAFAMAEMKVVLALTLLHFRILPTHTEP--RRKPELILRAEGGLWLRVEP 518
Score = 104 bits (250), Expect = 7e-22
Identities = 55/188 (29%), Positives = 99/188 (52%), Gaps = 8/188 (4%)
Query: 90 KIWIGPRL-LVFLYDPRDVEVILSSHVYIDKAEE--YRFFKPWLGNGLLISTGQKWRSHR 146
K+W+GP L+ L P + I S+ + + Y F KPWLG+GLL+S G KW HR
Sbjct: 89 KLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHR 148
Query: 147 KLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEAS----NFDCHDYMSECTVEILLETAM 202
+++ P FH N+LK ++ +FN + + DK ++ AS D +++S T++ L +
Sbjct: 149 RMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVF 208
Query: 203 GVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLT 262
+ Q++ EY A++++ + R+ +I L D L+ T + + ++H T
Sbjct: 209 SFESNCQEKPS-EYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFT 267
Query: 263 KKVIKRKK 270
VI+ ++
Sbjct: 268 DAVIQERR 275
>AL135960-10|CAI19737.1| 519|Homo sapiens cytochrome P450, family
4, subfamily A, polypeptide 22 protein.
Length = 519
Score = 175 bits (427), Expect = 3e-43
Identities = 88/228 (38%), Positives = 139/228 (60%), Gaps = 6/228 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+K+ L FLD LLL ++G +SD++++ +VDT MFEGHDTTA+G S+ L + H Q
Sbjct: 285 RKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQ 344
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
++ EE+ + GD +T+ +M Y C+ E LRLYPPVP I R+++ +T P +G
Sbjct: 345 ERCREEIHGLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFP-DG 402
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
+ +P G ++++ Y LH P V+PN FDP F P + +H +AF+PFS G R+C+G+
Sbjct: 403 RSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAP--GSAQHSHAFLPFSGGSRNCIGK 460
Query: 501 KYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQ 548
++AM +LKV + L F ++ D + A ++LK G +RL+
Sbjct: 461 QFAMNQLKVARALTLLRFELLPDPTRIPIPM-ARLVLKSKNGIHLRLR 507
Score = 78.2 bits (184), Expect = 7e-14
Identities = 50/191 (26%), Positives = 93/191 (48%), Gaps = 6/191 (3%)
Query: 87 SVVKIWI-GPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKPWLGNGLLISTGQKWRSH 145
S WI G ++ V LYDP ++VIL Y+F P +G GLL+ GQ W H
Sbjct: 84 SACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGS-YKFLAPRIGYGLLLLNGQTWFQH 142
Query: 146 RKLIAPTFHLNVLKSFIDLFNANSRAVVDK---LKKEASNFDCHDYMSECTVEILLETAM 202
R+++ P FH ++LK ++ L + R ++DK L + S + ++S T++ ++++A
Sbjct: 143 RRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAF 202
Query: 203 GVSKSTQ-DQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGL 261
S Q D++ Y A+ + ++ + D ++ T + + + H
Sbjct: 203 SHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQH 262
Query: 262 TKKVIKRKKEE 272
T +VI+ +K +
Sbjct: 263 TDQVIQLRKAQ 273
>AF208532-1|AAF76722.1| 519|Homo sapiens fatty acid
omega-hydroxylase CYP4A11 protein.
Length = 519
Score = 175 bits (427), Expect = 3e-43
Identities = 88/228 (38%), Positives = 139/228 (60%), Gaps = 6/228 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+K+ L FLD LLL ++G +SD++++ +VDT MFEGHDTTA+G S+ L + H Q
Sbjct: 285 RKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQ 344
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
++ EE+ + GD +T+ +M Y C+ E LRLYPPVP I R+++ +T P +G
Sbjct: 345 ERCREEIHGLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFP-DG 402
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
+ +P G ++++ Y LH P V+PN FDP F P + +H +AF+PFS G R+C+G+
Sbjct: 403 RSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAP--GSAQHSHAFLPFSGGSRNCIGK 460
Query: 501 KYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQ 548
++AM +LKV + L F ++ D + A ++LK G +RL+
Sbjct: 461 QFAMNQLKVARALTLLRFELLPDPTRIPIPI-ARLVLKSKNGIHLRLR 507
Score = 79.4 bits (187), Expect = 3e-14
Identities = 51/191 (26%), Positives = 93/191 (48%), Gaps = 6/191 (3%)
Query: 87 SVVKIWI-GPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKPWLGNGLLISTGQKWRSH 145
S WI G ++ V LYDP ++VIL YRF P +G GLL+ GQ W H
Sbjct: 84 SACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGS-YRFLAPRIGYGLLLLNGQTWFQH 142
Query: 146 RKLIAPTFHLNVLKSFIDLFNANSRAVVDK---LKKEASNFDCHDYMSECTVEILLETAM 202
R+++ P FH ++LK ++ L + R ++DK L + S + ++S T++ ++++A
Sbjct: 143 RRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAF 202
Query: 203 GVSKSTQ-DQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGL 261
S Q D++ Y A+ + ++ + D ++ T + + + H
Sbjct: 203 SHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQH 262
Query: 262 TKKVIKRKKEE 272
T +VI+ +K +
Sbjct: 263 TDQVIQLRKAQ 273
>S67581-1|AAB29503.1| 591|Homo sapiens fatty acid omega-hydroxylase
protein.
Length = 591
Score = 175 bits (426), Expect = 3e-43
Identities = 83/203 (40%), Positives = 129/203 (63%), Gaps = 5/203 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+K+ L FLD LLL ++G +SD++++ +VDT MFEGHDTTA+G S+ L + H Q
Sbjct: 285 RKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQ 344
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
++ EE+ + GD +T+ +M Y C+ E LRLYPPVP I R+++ +T P +G
Sbjct: 345 ERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFP-DG 402
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
+ +P G ++++ Y LH P V+PNP FDP F P + +H +AF+PFS G R+C+G+
Sbjct: 403 RSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPSRFAP--GSAQHSHAFLPFSGGSRNCIGK 460
Query: 501 KYAMLKLKVILSTILRNFRVISD 523
++AM +LKV + L F ++ D
Sbjct: 461 QFAMNELKVATALTLLRFELLPD 483
Score = 87.0 bits (206), Expect = 2e-16
Identities = 51/186 (27%), Positives = 95/186 (51%), Gaps = 6/186 (3%)
Query: 92 WI-GPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKPWLGNGLLISTGQKWRSHRKLIA 150
W+ G ++ V LYDP ++VIL YRF PW+G GLL+ GQ W HR+++
Sbjct: 89 WLWGGKVRVQLYDPDYMKVILGRSDPKSHGS-YRFLAPWIGYGLLLLNGQTWFQHRRMLT 147
Query: 151 PTFHLNVLKSFIDLFNANSRAVVDK---LKKEASNFDCHDYMSECTVEILLETAMGVSKS 207
P FH ++LK ++ L + R ++DK L + S + ++S T++ +++ A S
Sbjct: 148 PAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGS 207
Query: 208 TQ-DQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTKKVI 266
Q D++ Y A+ + +++ R + + D ++ T + + + H T +VI
Sbjct: 208 IQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVI 267
Query: 267 KRKKEE 272
+ +K +
Sbjct: 268 QLRKAQ 273
>AF236085-1|AAG15889.1| 524|Homo sapiens CYP4F11 protein.
Length = 524
Score = 175 bits (426), Expect = 3e-43
Identities = 86/230 (37%), Positives = 142/230 (61%), Gaps = 5/230 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+ K L F+D LLL + G +SDE+I+ + DT MFEGHDTTA+G S+ L + H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351
Query: 381 DKVIEELDQIFGDSDR-PVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSN 439
++ +E+ ++ D + + + D ++ +L C+ E+LRL+PPVP+I+R Q+ LP +
Sbjct: 352 EQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLP-D 410
Query: 440 GKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVG 499
G+ IP G +I +H P V+P+P +DP F E R AF+PFSAGPR+C+G
Sbjct: 411 GRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFNQENIKERSPLAFIPFSAGPRNCIG 470
Query: 500 RKYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ +AM ++KV+L+ L +FR++ E + + ++IL+ G +R++P
Sbjct: 471 QAFAMAEMKVVLALTLLHFRILPTHIEP--RRKPELILRAEGGLWLRVEP 518
Score = 104 bits (250), Expect = 7e-22
Identities = 55/188 (29%), Positives = 99/188 (52%), Gaps = 8/188 (4%)
Query: 90 KIWIGPRL-LVFLYDPRDVEVILSSHVYIDKAEE--YRFFKPWLGNGLLISTGQKWRSHR 146
K+W+GP L+ L P + I S+ + + Y F KPWLG+GLL+S G KW HR
Sbjct: 89 KLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHR 148
Query: 147 KLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEAS----NFDCHDYMSECTVEILLETAM 202
+++ P FH N+LK ++ +FN + + DK ++ AS D +++S T++ L +
Sbjct: 149 RMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVF 208
Query: 203 GVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLT 262
+ Q++ EY A++++ + R+ +I L D L+ T + + ++H T
Sbjct: 209 SFESNCQEKPS-EYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFT 267
Query: 263 KKVIKRKK 270
VI+ ++
Sbjct: 268 DAVIQERR 275
>D13705-1|BAA02864.1| 521|Homo sapiens fatty acid omega-hydroxylase
protein.
Length = 521
Score = 174 bits (424), Expect = 6e-43
Identities = 89/229 (38%), Positives = 140/229 (61%), Gaps = 7/229 (3%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+K+ L FLD LLL ++G +SD++++ +VDT MFEGHDTTA+G S+ L + H Q
Sbjct: 286 RKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQ 345
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
++ EE+ + GD +T+ +M Y C+ E LRLYPPVP I R+++ +T P +G
Sbjct: 346 ERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFP-DG 403
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
+ +P G ++++ Y LH P V+PNP FDP F P + +H +AF+PFS G R+C+G+
Sbjct: 404 RSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAP--GSAQHSHAFLPFSGGSRNCIGK 461
Query: 501 KYAMLKLKVILSTI-LRNFRVISDLKESDFKLQADIILKRAEGFQVRLQ 548
++AM +LKV + L F ++ D + A ++LK G +RL+
Sbjct: 462 QFAMNELKVGQQALTLVRFELLPDPTRIPIPI-ARLVLKSKNGIHLRLR 509
Score = 85.0 bits (201), Expect = 6e-16
Identities = 52/187 (27%), Positives = 96/187 (51%), Gaps = 7/187 (3%)
Query: 92 WI-GPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKPWLGNGLLISTGQKWRSHRKLIA 150
W+ G ++ V LYDP ++VIL YRF PW+G GLL+ GQ W HR+++
Sbjct: 89 WLWGGKVRVQLYDPDYMKVILGRSDPKSHGS-YRFLAPWIGYGLLLLNGQTWFQHRRMLT 147
Query: 151 PTFHLNVLKSFIDLFNANSRAVVDK---LKKEASNFDCHDYMSECTVEILLETAMGVSKS 207
P FH ++LK ++ L + R ++DK L + S + ++S T++ +++ A S
Sbjct: 148 PAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGS 207
Query: 208 TQ-DQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTK-KV 265
Q D++ Y A+ + +++ R + + D ++ T + + + H T+ KV
Sbjct: 208 IQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLSHQHTRPKV 267
Query: 266 IKRKKEE 272
I+ +K +
Sbjct: 268 IQLRKAQ 274
>BC093896-1|AAH93896.1| 531|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 2 homolog protein.
Length = 531
Score = 168 bits (408), Expect = 5e-41
Identities = 81/230 (35%), Positives = 140/230 (60%), Gaps = 4/230 (1%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
Q K L F+D LLL + G +SDE+I+ + DT MFEGHDTT++G S+ L + + + Q
Sbjct: 299 QGKTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQ 358
Query: 381 DKVIEELDQIF-GDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSN 439
+K EE+ ++ G + + D ++ + C+ E+LR YPPV +++RQ ++I LP +
Sbjct: 359 EKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLP-D 417
Query: 440 GKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVG 499
G+ IP G +++ Y H P V+P+ ++P F P+ R A+VPFSAGPR+C+G
Sbjct: 418 GRIIPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIG 477
Query: 500 RKYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ +AM +L+V+++ L FR+ D + + + ++IL+ G ++++P
Sbjct: 478 QSFAMAELRVVVALTLLRFRLSVD-RTRKVRRKPELILRTENGLWLKVEP 526
Score = 92.3 bits (219), Expect = 4e-18
Identities = 53/200 (26%), Positives = 107/200 (53%), Gaps = 9/200 (4%)
Query: 78 QKSADYDHESVVKIWIGPRL-LVFLYDPRDVEVILSSHVYIDKAEE--YRFFKPWLGNGL 134
+K D H V+ +W+GP L L+ L P ++ +L + I ++ Y F KPWLG+GL
Sbjct: 86 KKVLDNMHH-VLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGL 144
Query: 135 LISTGQKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKK----EASNFDCHDYMS 190
L+S G KW HR+L+ P FH ++LK ++ +FN ++ + K + A + D +++S
Sbjct: 145 LLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHIS 204
Query: 191 ECTVEILLETAMGVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKN 250
T++ L + + + Q++ +Y A++++ + R ++ D ++ + +
Sbjct: 205 LMTLDSLQKCVFSYNSNCQEKMS-DYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRR 263
Query: 251 QTKLLDIIHGLTKKVIKRKK 270
+ D++H T +VI+ ++
Sbjct: 264 FRQACDMVHHFTTEVIQERR 283
>BC093894-1|AAH93894.1| 531|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 2 homolog protein.
Length = 531
Score = 168 bits (408), Expect = 5e-41
Identities = 81/230 (35%), Positives = 140/230 (60%), Gaps = 4/230 (1%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
Q K L F+D LLL + G +SDE+I+ + DT MFEGHDTT++G S+ L + + + Q
Sbjct: 299 QGKTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQ 358
Query: 381 DKVIEELDQIF-GDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSN 439
+K EE+ ++ G + + D ++ + C+ E+LR YPPV +++RQ ++I LP +
Sbjct: 359 EKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLP-D 417
Query: 440 GKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVG 499
G+ IP G +++ Y H P V+P+ ++P F P+ R A+VPFSAGPR+C+G
Sbjct: 418 GRIIPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIG 477
Query: 500 RKYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ +AM +L+V+++ L FR+ D + + + ++IL+ G ++++P
Sbjct: 478 QSFAMAELRVVVALTLLRFRLSVD-RTRKVRRKPELILRTENGLWLKVEP 526
Score = 92.3 bits (219), Expect = 4e-18
Identities = 53/200 (26%), Positives = 107/200 (53%), Gaps = 9/200 (4%)
Query: 78 QKSADYDHESVVKIWIGPRL-LVFLYDPRDVEVILSSHVYIDKAEE--YRFFKPWLGNGL 134
+K D H V+ +W+GP L L+ L P ++ +L + I ++ Y F KPWLG+GL
Sbjct: 86 KKVLDNMHH-VLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGL 144
Query: 135 LISTGQKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKK----EASNFDCHDYMS 190
L+S G KW HR+L+ P FH ++LK ++ +FN ++ + K + A + D +++S
Sbjct: 145 LLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHIS 204
Query: 191 ECTVEILLETAMGVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKN 250
T++ L + + + Q++ +Y A++++ + R ++ D ++ + +
Sbjct: 205 LMTLDSLQKCVFSYNSNCQEKMS-DYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRR 263
Query: 251 QTKLLDIIHGLTKKVIKRKK 270
+ D++H T +VI+ ++
Sbjct: 264 FRQACDMVHHFTTEVIQERR 283
>BC069351-1|AAH69351.1| 531|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 2 homolog protein.
Length = 531
Score = 168 bits (408), Expect = 5e-41
Identities = 81/230 (35%), Positives = 140/230 (60%), Gaps = 4/230 (1%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
Q K L F+D LLL + G +SDE+I+ + DT MFEGHDTT++G S+ L + + + Q
Sbjct: 299 QGKTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQ 358
Query: 381 DKVIEELDQIF-GDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSN 439
+K EE+ ++ G + + D ++ + C+ E+LR YPPV +++RQ ++I LP +
Sbjct: 359 EKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLP-D 417
Query: 440 GKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVG 499
G+ IP G +++ Y H P V+P+ ++P F P+ R A+VPFSAGPR+C+G
Sbjct: 418 GRIIPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIG 477
Query: 500 RKYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ +AM +L+V+++ L FR+ D + + + ++IL+ G ++++P
Sbjct: 478 QSFAMAELRVVVALTLLRFRLSVD-RTRKVRRKPELILRTENGLWLKVEP 526
Score = 92.3 bits (219), Expect = 4e-18
Identities = 53/200 (26%), Positives = 107/200 (53%), Gaps = 9/200 (4%)
Query: 78 QKSADYDHESVVKIWIGPRL-LVFLYDPRDVEVILSSHVYIDKAEE--YRFFKPWLGNGL 134
+K D H V+ +W+GP L L+ L P ++ +L + I ++ Y F KPWLG+GL
Sbjct: 86 KKVLDNMHH-VLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGL 144
Query: 135 LISTGQKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKK----EASNFDCHDYMS 190
L+S G KW HR+L+ P FH ++LK ++ +FN ++ + K + A + D +++S
Sbjct: 145 LLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHIS 204
Query: 191 ECTVEILLETAMGVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKN 250
T++ L + + + Q++ +Y A++++ + R ++ D ++ + +
Sbjct: 205 LMTLDSLQKCVFSYNSNCQEKMS-DYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRR 263
Query: 251 QTKLLDIIHGLTKKVIKRKK 270
+ D++H T +VI+ ++
Sbjct: 264 FRQACDMVHHFTTEVIQERR 283
>AK096820-1|BAC04868.1| 531|Homo sapiens protein ( Homo sapiens
cDNA FLJ39501 fis, clone PROST2016980, moderately
similar to CYTOCHROME P450 4F2 (EC 1.14.13.30). ).
Length = 531
Score = 168 bits (408), Expect = 5e-41
Identities = 81/230 (35%), Positives = 140/230 (60%), Gaps = 4/230 (1%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
Q K L F+D LLL + G +SDE+I+ + DT MFEGHDTT++G S+ L + + + Q
Sbjct: 299 QGKTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQ 358
Query: 381 DKVIEELDQIF-GDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSN 439
+K EE+ ++ G + + D ++ + C+ E+LR YPPV +++RQ ++I LP +
Sbjct: 359 EKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLP-D 417
Query: 440 GKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVG 499
G+ IP G +++ Y H P V+P+ ++P F P+ R A+VPFSAGPR+C+G
Sbjct: 418 GRIIPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIG 477
Query: 500 RKYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ +AM +L+V+++ L FR+ D + + + ++IL+ G ++++P
Sbjct: 478 QSFAMAELRVVVALTLLRFRLSVD-RTRKVRRKPELILRTENGLWLKVEP 526
Score = 90.2 bits (214), Expect = 2e-17
Identities = 52/200 (26%), Positives = 106/200 (53%), Gaps = 9/200 (4%)
Query: 78 QKSADYDHESVVKIWIGPRL-LVFLYDPRDVEVILSSHVYIDKAEE--YRFFKPWLGNGL 134
+K D H V+ +W+GP L L+ L P ++ +L + ++ Y F KPWLG+GL
Sbjct: 86 KKVLDNMHH-VLLVWMGPVLPLLVLVHPDYIKPLLGASAATAPKDDLFYGFLKPWLGDGL 144
Query: 135 LISTGQKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKK----EASNFDCHDYMS 190
L+S G KW HR+L+ P FH ++LK ++ +FN ++ + K + A + D +++S
Sbjct: 145 LLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHIS 204
Query: 191 ECTVEILLETAMGVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKN 250
T++ L + + + Q++ +Y A++++ + R ++ D ++ + +
Sbjct: 205 LMTLDSLQKCVFSYNSNCQEKMS-DYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRR 263
Query: 251 QTKLLDIIHGLTKKVIKRKK 270
+ D++H T +VI+ ++
Sbjct: 264 FRQACDMVHHFTTEVIQERR 283
>BC028102-1|AAH28102.1| 509|Homo sapiens cytochrome P450, family 4,
subfamily X, polypeptide 1 protein.
Length = 509
Score = 166 bits (403), Expect = 2e-40
Identities = 87/228 (38%), Positives = 135/228 (59%), Gaps = 4/228 (1%)
Query: 322 QKKRLAFLDLLLESS-QSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
++K FLD++L + +SG + SD ++ +V T + GHDT AA S+ L + ++ + Q
Sbjct: 280 KRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQ 339
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
++ EE+ I GD +T+ EM Y C+ ET RL P VP I+R +++ +T P +G
Sbjct: 340 ERCREEVRGILGDGSS-ITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFP-DG 397
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
+PAG T+V++ + LH P V+ NP FDP F E S RH YA++PFSAG R+C+G+
Sbjct: 398 CTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQ 457
Query: 501 KYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQ 548
++AM++LKV ++ IL +FRV D ILK G + L+
Sbjct: 458 EFAMIELKVTIALILLHFRVTPD-PTRPLTFPNHFILKPKNGMYLHLK 504
Score = 95.5 bits (227), Expect = 4e-19
Identities = 56/198 (28%), Positives = 102/198 (51%), Gaps = 11/198 (5%)
Query: 92 WIGPRLLVF-LYDPRDVEVILSSHVYIDKAEEY--RFFKPWLGNGLLISTGQKWRSHRKL 148
WIGP F +YDP + +LS D +Y +F P LG GL G KW HR+L
Sbjct: 83 WIGPFQAFFCIYDPDYAKTLLSR---TDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRL 139
Query: 149 IAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASNFD----CHDYMSECTVEILLETAMGV 204
+ P FH N+LK++I++ + + ++DK +K S D +++++ +++I+++ A
Sbjct: 140 LTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSK 199
Query: 205 SKSTQDQSGFE-YAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTK 263
+ Q S + YA A+ ++ I+ R + D++FK + KL +++ T
Sbjct: 200 ETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTD 259
Query: 264 KVIKRKKEEFASGKKPSN 281
+I+ +K+ +G K N
Sbjct: 260 TIIQERKKSLQAGVKQDN 277
>AY358537-1|AAQ88901.1| 509|Homo sapiens EFSW1929 protein.
Length = 509
Score = 166 bits (403), Expect = 2e-40
Identities = 87/228 (38%), Positives = 135/228 (59%), Gaps = 4/228 (1%)
Query: 322 QKKRLAFLDLLLESS-QSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
++K FLD++L + +SG + SD ++ +V T + GHDT AA S+ L + ++ + Q
Sbjct: 280 KRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQ 339
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
++ EE+ I GD +T+ EM Y C+ ET RL P VP I+R +++ +T P +G
Sbjct: 340 ERCREEVRGILGDGSS-ITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFP-DG 397
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
+PAG T+V++ + LH P V+ NP FDP F E S RH YA++PFSAG R+C+G+
Sbjct: 398 CTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQ 457
Query: 501 KYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQ 548
++AM++LKV ++ IL +FRV D ILK G + L+
Sbjct: 458 EFAMIELKVTIALILLHFRVTPD-PTRPLTFPNHFILKPKNGMYLHLK 504
Score = 95.5 bits (227), Expect = 4e-19
Identities = 56/198 (28%), Positives = 102/198 (51%), Gaps = 11/198 (5%)
Query: 92 WIGPRLLVF-LYDPRDVEVILSSHVYIDKAEEY--RFFKPWLGNGLLISTGQKWRSHRKL 148
WIGP F +YDP + +LS D +Y +F P LG GL G KW HR+L
Sbjct: 83 WIGPFQAFFCIYDPDYAKTLLSR---TDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRL 139
Query: 149 IAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASNFD----CHDYMSECTVEILLETAMGV 204
+ P FH N+LK++I++ + + ++DK +K S D +++++ +++I+++ A
Sbjct: 140 LTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSK 199
Query: 205 SKSTQDQSGFE-YAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTK 263
+ Q S + YA A+ ++ I+ R + D++FK + KL +++ T
Sbjct: 200 ETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTD 259
Query: 264 KVIKRKKEEFASGKKPSN 281
+I+ +K+ +G K N
Sbjct: 260 TIIQERKKSLQAGVKQDN 277
>AM040940-1|CAJ13826.1| 509|Homo sapiens cytochrome P450 protein.
Length = 509
Score = 166 bits (403), Expect = 2e-40
Identities = 87/228 (38%), Positives = 135/228 (59%), Gaps = 4/228 (1%)
Query: 322 QKKRLAFLDLLLESS-QSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
++K FLD++L + +SG + SD ++ +V T + GHDT AA S+ L + ++ + Q
Sbjct: 280 KRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQ 339
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
++ EE+ I GD +T+ EM Y C+ ET RL P VP I+R +++ +T P +G
Sbjct: 340 ERCREEVRGILGDGSS-ITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFP-DG 397
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
+PAG T+V++ + LH P V+ NP FDP F E S RH YA++PFSAG R+C+G+
Sbjct: 398 CTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQ 457
Query: 501 KYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQ 548
++AM++LKV ++ IL +FRV D ILK G + L+
Sbjct: 458 EFAMIELKVTIALILLHFRVTPD-PTRPLTFPNHFILKPKNGMYLHLK 504
Score = 95.5 bits (227), Expect = 4e-19
Identities = 56/198 (28%), Positives = 102/198 (51%), Gaps = 11/198 (5%)
Query: 92 WIGPRLLVF-LYDPRDVEVILSSHVYIDKAEEY--RFFKPWLGNGLLISTGQKWRSHRKL 148
WIGP F +YDP + +LS D +Y +F P LG GL G KW HR+L
Sbjct: 83 WIGPFQAFFCIYDPDYAKTLLSR---TDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRL 139
Query: 149 IAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASNFD----CHDYMSECTVEILLETAMGV 204
+ P FH N+LK++I++ + + ++DK +K S D +++++ +++I+++ A
Sbjct: 140 LTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSK 199
Query: 205 SKSTQDQSGFE-YAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTK 263
+ Q S + YA A+ ++ I+ R + D++FK + KL +++ T
Sbjct: 200 ETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTD 259
Query: 264 KVIKRKKEEFASGKKPSN 281
+I+ +K+ +G K N
Sbjct: 260 TIIQERKKSLQAGVKQDN 277
>AL450996-1|CAH71035.1| 509|Homo sapiens cytochrome P450, family 4,
subfamily X, polypeptide 1 protein.
Length = 509
Score = 166 bits (403), Expect = 2e-40
Identities = 87/228 (38%), Positives = 135/228 (59%), Gaps = 4/228 (1%)
Query: 322 QKKRLAFLDLLLESS-QSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
++K FLD++L + +SG + SD ++ +V T + GHDT AA S+ L + ++ + Q
Sbjct: 280 KRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQ 339
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
++ EE+ I GD +T+ EM Y C+ ET RL P VP I+R +++ +T P +G
Sbjct: 340 ERCREEVRGILGDGSS-ITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFP-DG 397
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
+PAG T+V++ + LH P V+ NP FDP F E S RH YA++PFSAG R+C+G+
Sbjct: 398 CTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQ 457
Query: 501 KYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQ 548
++AM++LKV ++ IL +FRV D ILK G + L+
Sbjct: 458 EFAMIELKVTIALILLHFRVTPD-PTRPLTFPNHFILKPKNGMYLHLK 504
Score = 95.5 bits (227), Expect = 4e-19
Identities = 56/198 (28%), Positives = 102/198 (51%), Gaps = 11/198 (5%)
Query: 92 WIGPRLLVF-LYDPRDVEVILSSHVYIDKAEEY--RFFKPWLGNGLLISTGQKWRSHRKL 148
WIGP F +YDP + +LS D +Y +F P LG GL G KW HR+L
Sbjct: 83 WIGPFQAFFCIYDPDYAKTLLSR---TDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRL 139
Query: 149 IAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASNFD----CHDYMSECTVEILLETAMGV 204
+ P FH N+LK++I++ + + ++DK +K S D +++++ +++I+++ A
Sbjct: 140 LTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSK 199
Query: 205 SKSTQDQSGFE-YAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTK 263
+ Q S + YA A+ ++ I+ R + D++FK + KL +++ T
Sbjct: 200 ETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTD 259
Query: 264 KVIKRKKEEFASGKKPSN 281
+I+ +K+ +G K N
Sbjct: 260 TIIQERKKSLQAGVKQDN 277
>AK131355-1|BAD18508.1| 508|Homo sapiens protein ( Homo sapiens
cDNA FLJ16384 fis, clone TLIVE2007607, weakly similar
to CYTOCHROME P450 4A4 (EC 1.14.14.1). ).
Length = 508
Score = 166 bits (403), Expect = 2e-40
Identities = 87/228 (38%), Positives = 135/228 (59%), Gaps = 4/228 (1%)
Query: 322 QKKRLAFLDLLLESS-QSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
++K FLD++L + +SG + SD ++ +V T + GHDT AA S+ L + ++ + Q
Sbjct: 279 KRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQ 338
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
++ EE+ I GD +T+ EM Y C+ ET RL P VP I+R +++ +T P +G
Sbjct: 339 ERCREEVRGILGDGSS-ITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFP-DG 396
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
+PAG T+V++ + LH P V+ NP FDP F E S RH YA++PFSAG R+C+G+
Sbjct: 397 CTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQ 456
Query: 501 KYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQ 548
++AM++LKV ++ IL +FRV D ILK G + L+
Sbjct: 457 EFAMIELKVTIALILLHFRVTPD-PTRPLTFPNHFILKPKNGMYLHLK 503
Score = 95.1 bits (226), Expect = 6e-19
Identities = 56/198 (28%), Positives = 102/198 (51%), Gaps = 11/198 (5%)
Query: 92 WIGPRLLVF-LYDPRDVEVILSSHVYIDKAEEY--RFFKPWLGNGLLISTGQKWRSHRKL 148
WIGP F +YDP + +LS D +Y +F P LG GL G KW HR+L
Sbjct: 82 WIGPFQAFFCIYDPDYAKTLLSR---TDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRL 138
Query: 149 IAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASNFD----CHDYMSECTVEILLETAMGV 204
+ P FH N+LK++I++ + + ++DK +K S D +++++ +++I+++ A
Sbjct: 139 LTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIVMKCAFSK 198
Query: 205 SKSTQDQSGFE-YAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTK 263
+ Q S + YA A+ ++ I+ R + D++FK + KL +++ T
Sbjct: 199 ETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTD 258
Query: 264 KVIKRKKEEFASGKKPSN 281
+I+ +K+ +G K N
Sbjct: 259 TIIQERKKSLQAGVKQDN 276
>AK098065-1|BAC05226.1| 509|Homo sapiens protein ( Homo sapiens
cDNA FLJ40746 fis, clone TRACH2000359, weakly similar to
CYTOCHROME P450 4A4 (EC 1.14.14.1). ).
Length = 509
Score = 166 bits (403), Expect = 2e-40
Identities = 87/228 (38%), Positives = 135/228 (59%), Gaps = 4/228 (1%)
Query: 322 QKKRLAFLDLLLESS-QSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
++K FLD++L + +SG + SD ++ +V T + GHDT AA S+ L + ++ + Q
Sbjct: 280 KRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQ 339
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
++ EE+ I GD +T+ EM Y C+ ET RL P VP I+R +++ +T P +G
Sbjct: 340 ERCREEVRGILGDGSS-ITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFP-DG 397
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
+PAG T+V++ + LH P V+ NP FDP F E S RH YA++PFSAG R+C+G+
Sbjct: 398 CTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQ 457
Query: 501 KYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQ 548
++AM++LKV ++ IL +FRV D ILK G + L+
Sbjct: 458 EFAMIELKVTIALILLHFRVTPD-PTRPLTFPNHFILKPKNGMYLHLK 504
Score = 95.5 bits (227), Expect = 4e-19
Identities = 56/198 (28%), Positives = 102/198 (51%), Gaps = 11/198 (5%)
Query: 92 WIGPRLLVF-LYDPRDVEVILSSHVYIDKAEEY--RFFKPWLGNGLLISTGQKWRSHRKL 148
WIGP F +YDP + +LS D +Y +F P LG GL G KW HR+L
Sbjct: 83 WIGPFQAFFCIYDPDYAKTLLSR---TDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRL 139
Query: 149 IAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASNFD----CHDYMSECTVEILLETAMGV 204
+ P FH N+LK++I++ + + ++DK +K S D +++++ +++I+++ A
Sbjct: 140 LTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSK 199
Query: 205 SKSTQDQSGFE-YAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTK 263
+ Q S + YA A+ ++ I+ R + D++FK + KL +++ T
Sbjct: 200 ETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTD 259
Query: 264 KVIKRKKEEFASGKKPSN 281
+I+ +K+ +G K N
Sbjct: 260 TIIQERKKSLQAGVKQDN 277
>AK091806-1|BAC03751.1| 444|Homo sapiens protein ( Homo sapiens
cDNA FLJ34487 fis, clone HLUNG2004273, weakly similar to
CYTOCHROME P450 4A4 (EC 1.14.14.1). ).
Length = 444
Score = 166 bits (403), Expect = 2e-40
Identities = 87/228 (38%), Positives = 135/228 (59%), Gaps = 4/228 (1%)
Query: 322 QKKRLAFLDLLLESS-QSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
++K FLD++L + +SG + SD ++ +V T + GHDT AA S+ L + ++ + Q
Sbjct: 215 KRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQ 274
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
++ EE+ I GD +T+ EM Y C+ ET RL P VP I+R +++ +T P +G
Sbjct: 275 ERCREEVRGILGDGSS-ITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFP-DG 332
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
+PAG T+V++ + LH P V+ NP FDP F E S RH YA++PFSAG R+C+G+
Sbjct: 333 CTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQ 392
Query: 501 KYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQ 548
++AM++LKV ++ IL +FRV D ILK G + L+
Sbjct: 393 EFAMIELKVTIALILLHFRVTPD-PTRPLTFPNHFILKPKNGMYLHLK 439
Score = 95.5 bits (227), Expect = 4e-19
Identities = 56/198 (28%), Positives = 102/198 (51%), Gaps = 11/198 (5%)
Query: 92 WIGPRLLVF-LYDPRDVEVILSSHVYIDKAEEY--RFFKPWLGNGLLISTGQKWRSHRKL 148
WIGP F +YDP + +LS D +Y +F P LG GL G KW HR+L
Sbjct: 18 WIGPFQAFFCIYDPDYAKTLLSR---TDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRL 74
Query: 149 IAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASNFD----CHDYMSECTVEILLETAMGV 204
+ P FH N+LK++I++ + + ++DK +K S D +++++ +++I+++ A
Sbjct: 75 LTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSK 134
Query: 205 SKSTQDQSGFE-YAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTK 263
+ Q S + YA A+ ++ I+ R + D++FK + KL +++ T
Sbjct: 135 ETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTD 194
Query: 264 KVIKRKKEEFASGKKPSN 281
+I+ +K+ +G K N
Sbjct: 195 TIIQERKKSLQAGVKQDN 212
>BC041158-1|AAH41158.1| 455|Homo sapiens CYP4A11 protein protein.
Length = 455
Score = 151 bits (365), Expect = 8e-36
Identities = 73/175 (41%), Positives = 110/175 (62%), Gaps = 5/175 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+K+ L FLD LLL ++G +SD++++ +VDT MFEGHDTTA+G S+ L + H Q
Sbjct: 285 RKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQ 344
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
++ EE+ + GD +T+ +M Y C+ E LRLYPPVP I R+++ +T P +G
Sbjct: 345 ERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFP-DG 402
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPR 495
+ +P G ++++ Y LH P V+PNP FDP F P + +H +AF+PFS G R
Sbjct: 403 RSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAP--GSAQHSHAFLPFSGGSR 455
Score = 87.0 bits (206), Expect = 2e-16
Identities = 51/186 (27%), Positives = 95/186 (51%), Gaps = 6/186 (3%)
Query: 92 WI-GPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKPWLGNGLLISTGQKWRSHRKLIA 150
W+ G ++ V LYDP ++VIL YRF PW+G GLL+ GQ W HR+++
Sbjct: 89 WLWGGKVRVQLYDPDYMKVILGRSDPKSHGS-YRFLAPWIGYGLLLLNGQTWFQHRRMLT 147
Query: 151 PTFHLNVLKSFIDLFNANSRAVVDK---LKKEASNFDCHDYMSECTVEILLETAMGVSKS 207
P FH ++LK ++ L + R ++DK L + S + ++S T++ +++ A S
Sbjct: 148 PAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGS 207
Query: 208 TQ-DQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTKKVI 266
Q D++ Y A+ + +++ R + + D ++ T + + + H T +VI
Sbjct: 208 IQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVI 267
Query: 267 KRKKEE 272
+ +K +
Sbjct: 268 QLRKAQ 273
>AL731892-4|CAH72779.1| 455|Homo sapiens cytochrome P450, family 4,
subfamily A, polypeptide 11 protein.
Length = 455
Score = 151 bits (365), Expect = 8e-36
Identities = 73/175 (41%), Positives = 110/175 (62%), Gaps = 5/175 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+K+ L FLD LLL ++G +SD++++ +VDT MFEGHDTTA+G S+ L + H Q
Sbjct: 285 RKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQ 344
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
++ EE+ + GD +T+ +M Y C+ E LRLYPPVP I R+++ +T P +G
Sbjct: 345 ERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFP-DG 402
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPR 495
+ +P G ++++ Y LH P V+PNP FDP F P + +H +AF+PFS G R
Sbjct: 403 RSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAP--GSAQHSHAFLPFSGGSR 455
Score = 87.0 bits (206), Expect = 2e-16
Identities = 51/186 (27%), Positives = 95/186 (51%), Gaps = 6/186 (3%)
Query: 92 WI-GPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKPWLGNGLLISTGQKWRSHRKLIA 150
W+ G ++ V LYDP ++VIL YRF PW+G GLL+ GQ W HR+++
Sbjct: 89 WLWGGKVRVQLYDPDYMKVILGRSDPKSHGS-YRFLAPWIGYGLLLLNGQTWFQHRRMLT 147
Query: 151 PTFHLNVLKSFIDLFNANSRAVVDK---LKKEASNFDCHDYMSECTVEILLETAMGVSKS 207
P FH ++LK ++ L + R ++DK L + S + ++S T++ +++ A S
Sbjct: 148 PAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGS 207
Query: 208 TQ-DQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTKKVI 266
Q D++ Y A+ + +++ R + + D ++ T + + + H T +VI
Sbjct: 208 IQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVI 267
Query: 267 KRKKEE 272
+ +K +
Sbjct: 268 QLRKAQ 273
>AY358631-1|AAQ88994.1| 505|Homo sapiens EPSW3060 protein.
Length = 505
Score = 150 bits (363), Expect = 1e-35
Identities = 78/225 (34%), Positives = 132/225 (58%), Gaps = 4/225 (1%)
Query: 322 QKKRLAFLDLLLES-SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
QK+R FLD+LL + S++ S+ +++ +V T MF GHDTT++ S+ L + + + Q
Sbjct: 278 QKRRWDFLDILLSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQ 337
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
+ +E+ ++ GD +T++ +M Y C+ E LRLY PV I+R +++ IT P +G
Sbjct: 338 QRCRDEIRELLGDGSS-ITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFP-DG 395
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
+ +PAG T+ I + LH P + +P F+P F E S H YAF+PFSAG R+C+G+
Sbjct: 396 RSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQ 455
Query: 501 KYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQV 545
+A+++ KV ++ L F++ D ++ ++LK G V
Sbjct: 456 HFAIIECKVAVALTLLRFKLAPDHSRPPQPVR-QVVLKSKNGIHV 499
Score = 91.5 bits (217), Expect = 7e-18
Identities = 53/188 (28%), Positives = 99/188 (52%), Gaps = 6/188 (3%)
Query: 89 VKIWIGPRLLVF-LYDPRDVEVILSSHVYIDKAEEYRFFKPWLGNGLLISTGQKWRSHRK 147
V +W+GP + F ++DP D IL A ++ + W+G GL+ G KW+ HR+
Sbjct: 80 VPLWVGPFTMFFSVHDP-DYAKILLKRQDPKSAVSHKILESWVGRGLVTLDGSKWKKHRQ 138
Query: 148 LIAPTFHLNVLKSFIDLFNANSRAVVDKLKK---EASNFDCHDYMSECTVEILLETAMGV 204
++ P F++++LK FI + + + R +++K ++ + S + ++S T++ +++ A
Sbjct: 139 IVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSH 198
Query: 205 SKSTQ-DQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTK 263
S Q D + Y AV + I + R DL+FKF+ + +K +H T+
Sbjct: 199 QGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFTE 258
Query: 264 KVIKRKKE 271
KVI+ +KE
Sbjct: 259 KVIQDRKE 266
>AY262056-1|AAO89257.1| 505|Homo sapiens cytochrome P450 protein.
Length = 505
Score = 150 bits (363), Expect = 1e-35
Identities = 78/225 (34%), Positives = 132/225 (58%), Gaps = 4/225 (1%)
Query: 322 QKKRLAFLDLLLES-SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
QK+R FLD+LL + S++ S+ +++ +V T MF GHDTT++ S+ L + + + Q
Sbjct: 278 QKRRWDFLDILLSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQ 337
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
+ +E+ ++ GD +T++ +M Y C+ E LRLY PV I+R +++ IT P +G
Sbjct: 338 QRCRDEIRELLGDGSS-ITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFP-DG 395
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
+ +PAG T+ I + LH P + +P F+P F E S H YAF+PFSAG R+C+G+
Sbjct: 396 RSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQ 455
Query: 501 KYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQV 545
+A+++ KV ++ L F++ D ++ ++LK G V
Sbjct: 456 HFAIIECKVAVALTLLRFKLAPDHSRPPQPVR-QVVLKSKNGIHV 499
Score = 91.5 bits (217), Expect = 7e-18
Identities = 53/188 (28%), Positives = 99/188 (52%), Gaps = 6/188 (3%)
Query: 89 VKIWIGPRLLVF-LYDPRDVEVILSSHVYIDKAEEYRFFKPWLGNGLLISTGQKWRSHRK 147
V +W+GP + F ++DP D IL A ++ + W+G GL+ G KW+ HR+
Sbjct: 80 VPLWVGPFTMFFSVHDP-DYAKILLKRQDPKSAVSHKILESWVGRGLVTLDGSKWKKHRQ 138
Query: 148 LIAPTFHLNVLKSFIDLFNANSRAVVDKLKK---EASNFDCHDYMSECTVEILLETAMGV 204
++ P F++++LK FI + + + R +++K ++ + S + ++S T++ +++ A
Sbjct: 139 IVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSH 198
Query: 205 SKSTQ-DQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTK 263
S Q D + Y AV + I + R DL+FKF+ + +K +H T+
Sbjct: 199 QGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFTE 258
Query: 264 KVIKRKKE 271
KVI+ +KE
Sbjct: 259 KVIQDRKE 266
>AL450996-2|CAH71036.1| 505|Homo sapiens cytochrome P450, family 4,
subfamily Z, polypeptide 1 protein.
Length = 505
Score = 150 bits (363), Expect = 1e-35
Identities = 78/225 (34%), Positives = 132/225 (58%), Gaps = 4/225 (1%)
Query: 322 QKKRLAFLDLLLES-SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
QK+R FLD+LL + S++ S+ +++ +V T MF GHDTT++ S+ L + + + Q
Sbjct: 278 QKRRWDFLDILLSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQ 337
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
+ +E+ ++ GD +T++ +M Y C+ E LRLY PV I+R +++ IT P +G
Sbjct: 338 QRCRDEIRELLGDGSS-ITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFP-DG 395
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
+ +PAG T+ I + LH P + +P F+P F E S H YAF+PFSAG R+C+G+
Sbjct: 396 RSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQ 455
Query: 501 KYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQV 545
+A+++ KV ++ L F++ D ++ ++LK G V
Sbjct: 456 HFAIIECKVAVALTLLRFKLAPDHSRPPQPVR-QVVLKSKNGIHV 499
Score = 91.5 bits (217), Expect = 7e-18
Identities = 53/188 (28%), Positives = 99/188 (52%), Gaps = 6/188 (3%)
Query: 89 VKIWIGPRLLVF-LYDPRDVEVILSSHVYIDKAEEYRFFKPWLGNGLLISTGQKWRSHRK 147
V +W+GP + F ++DP D IL A ++ + W+G GL+ G KW+ HR+
Sbjct: 80 VPLWVGPFTMFFSVHDP-DYAKILLKRQDPKSAVSHKILESWVGRGLVTLDGSKWKKHRQ 138
Query: 148 LIAPTFHLNVLKSFIDLFNANSRAVVDKLKK---EASNFDCHDYMSECTVEILLETAMGV 204
++ P F++++LK FI + + + R +++K ++ + S + ++S T++ +++ A
Sbjct: 139 IVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSH 198
Query: 205 SKSTQ-DQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTK 263
S Q D + Y AV + I + R DL+FKF+ + +K +H T+
Sbjct: 199 QGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFTE 258
Query: 264 KVIKRKKE 271
KVI+ +KE
Sbjct: 259 KVIQDRKE 266
>AL135960-6|CAI19734.1| 505|Homo sapiens cytochrome P450, family 4,
subfamily Z, polypeptide 1 protein.
Length = 505
Score = 150 bits (363), Expect = 1e-35
Identities = 78/225 (34%), Positives = 132/225 (58%), Gaps = 4/225 (1%)
Query: 322 QKKRLAFLDLLLES-SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
QK+R FLD+LL + S++ S+ +++ +V T MF GHDTT++ S+ L + + + Q
Sbjct: 278 QKRRWDFLDILLSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQ 337
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
+ +E+ ++ GD +T++ +M Y C+ E LRLY PV I+R +++ IT P +G
Sbjct: 338 QRCRDEIRELLGDGSS-ITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFP-DG 395
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
+ +PAG T+ I + LH P + +P F+P F E S H YAF+PFSAG R+C+G+
Sbjct: 396 RSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQ 455
Query: 501 KYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQV 545
+A+++ KV ++ L F++ D ++ ++LK G V
Sbjct: 456 HFAIIECKVAVALTLLRFKLAPDHSRPPQPVR-QVVLKSKNGIHV 499
Score = 91.5 bits (217), Expect = 7e-18
Identities = 53/188 (28%), Positives = 99/188 (52%), Gaps = 6/188 (3%)
Query: 89 VKIWIGPRLLVF-LYDPRDVEVILSSHVYIDKAEEYRFFKPWLGNGLLISTGQKWRSHRK 147
V +W+GP + F ++DP D IL A ++ + W+G GL+ G KW+ HR+
Sbjct: 80 VPLWVGPFTMFFSVHDP-DYAKILLKRQDPKSAVSHKILESWVGRGLVTLDGSKWKKHRQ 138
Query: 148 LIAPTFHLNVLKSFIDLFNANSRAVVDKLKK---EASNFDCHDYMSECTVEILLETAMGV 204
++ P F++++LK FI + + + R +++K ++ + S + ++S T++ +++ A
Sbjct: 139 IVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSH 198
Query: 205 SKSTQ-DQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTK 263
S Q D + Y AV + I + R DL+FKF+ + +K +H T+
Sbjct: 199 QGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFTE 258
Query: 264 KVIKRKKE 271
KVI+ +KE
Sbjct: 259 KVIQDRKE 266
>AL135960-11|CAI19738.1| 455|Homo sapiens cytochrome P450, family
4, subfamily A, polypeptide 22 protein.
Length = 455
Score = 147 bits (356), Expect = 1e-34
Identities = 72/175 (41%), Positives = 109/175 (62%), Gaps = 5/175 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+K+ L FLD LLL ++G +SD++++ +VDT MFEGHDTTA+G S+ L + H Q
Sbjct: 285 RKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQ 344
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
++ EE+ + GD +T+ +M Y C+ E LRLYPPVP I R+++ +T P +G
Sbjct: 345 ERCREEIHGLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFP-DG 402
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPR 495
+ +P G ++++ Y LH P V+PN FDP F P + +H +AF+PFS G R
Sbjct: 403 RSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAP--GSAQHSHAFLPFSGGSR 455
Score = 78.2 bits (184), Expect = 7e-14
Identities = 50/191 (26%), Positives = 93/191 (48%), Gaps = 6/191 (3%)
Query: 87 SVVKIWI-GPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKPWLGNGLLISTGQKWRSH 145
S WI G ++ V LYDP ++VIL Y+F P +G GLL+ GQ W H
Sbjct: 84 SACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGS-YKFLAPRIGYGLLLLNGQTWFQH 142
Query: 146 RKLIAPTFHLNVLKSFIDLFNANSRAVVDK---LKKEASNFDCHDYMSECTVEILLETAM 202
R+++ P FH ++LK ++ L + R ++DK L + S + ++S T++ ++++A
Sbjct: 143 RRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAF 202
Query: 203 GVSKSTQ-DQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGL 261
S Q D++ Y A+ + ++ + D ++ T + + + H
Sbjct: 203 SHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQH 262
Query: 262 TKKVIKRKKEE 272
T +VI+ +K +
Sbjct: 263 TDQVIQLRKAQ 273
>M18907-1|AAA35745.1| 503|Homo sapiens protein ( Human P450 mRNA
encoding nifedipine oxidase, complete cds. ).
Length = 503
Score = 140 bits (339), Expect = 1e-32
Identities = 73/219 (33%), Positives = 125/219 (57%), Gaps = 9/219 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK R+ FL L+++S ++S A+SD E+ Q +F G++TT++ SF + + H
Sbjct: 265 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q K+ EE+D + + P T+ L+M+YL+ + ETLRL+P + R +++ +
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRS 496
NG IP G ++I +Y LHR P + P KF P+ F + N Y + PF +GPR+
Sbjct: 384 --NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 497 CVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQADI 535
C+G ++A++ +K+ L +L+NF KE+ L+ +
Sbjct: 442 CIGMRFALMNMKLALIRVLQNFS-FKPCKETQIPLKLSL 479
Score = 39.5 bits (88), Expect = 0.030
Identities = 28/129 (21%), Positives = 59/129 (45%), Gaps = 9/129 (6%)
Query: 85 HESVVKIW---IGPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKP--WLGNGLLISTG 139
H+ K+W G + ++ + DP ++ +L Y R F P ++ + + I+
Sbjct: 65 HKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKSAISIAED 123
Query: 140 QKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASN---FDCHDYMSECTVEI 196
++W+ R L++PTF LK + + +V L++EA D ++++
Sbjct: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 183
Query: 197 LLETAMGVS 205
+ T+ GV+
Sbjct: 184 ITSTSFGVN 192
>DQ924960-1|ABI96208.1| 503|Homo sapiens cytochrome P450 family 3
subfamily A polypeptide 4 protein.
Length = 503
Score = 140 bits (339), Expect = 1e-32
Identities = 73/219 (33%), Positives = 125/219 (57%), Gaps = 9/219 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK R+ FL L+++S ++S A+SD E+ Q +F G++TT++ SF + + H
Sbjct: 265 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q K+ EE+D + + P T+ L+M+YL+ + ETLRL+P + R +++ +
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRS 496
NG IP G ++I +Y LHR P + P KF P+ F + N Y + PF +GPR+
Sbjct: 384 --NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 497 CVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQADI 535
C+G ++A++ +K+ L +L+NF KE+ L+ +
Sbjct: 442 CIGMRFALMNMKLALIRVLQNFS-FKPCKETQIPLKLSL 479
Score = 39.5 bits (88), Expect = 0.030
Identities = 28/129 (21%), Positives = 59/129 (45%), Gaps = 9/129 (6%)
Query: 85 HESVVKIW---IGPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKP--WLGNGLLISTG 139
H+ K+W G + ++ + DP ++ +L Y R F P ++ + + I+
Sbjct: 65 HKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKSAISIAED 123
Query: 140 QKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASN---FDCHDYMSECTVEI 196
++W+ R L++PTF LK + + +V L++EA D ++++
Sbjct: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 183
Query: 197 LLETAMGVS 205
+ T+ GV+
Sbjct: 184 ITSTSFGVN 192
>DQ005611-1|AAY16980.1| 503|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 4 protein.
Length = 503
Score = 140 bits (339), Expect = 1e-32
Identities = 73/219 (33%), Positives = 125/219 (57%), Gaps = 9/219 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK R+ FL L+++S ++S A+SD E+ Q +F G++TT++ SF + + H
Sbjct: 265 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q K+ EE+D + + P T+ L+M+YL+ + ETLRL+P + R +++ +
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRS 496
NG IP G ++I +Y LHR P + P KF P+ F + N Y + PF +GPR+
Sbjct: 384 --NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 497 CVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQADI 535
C+G ++A++ +K+ L +L+NF KE+ L+ +
Sbjct: 442 CIGMRFALMNMKLALIRVLQNFS-FKPCKETQIPLKLSL 479
Score = 39.5 bits (88), Expect = 0.030
Identities = 28/129 (21%), Positives = 59/129 (45%), Gaps = 9/129 (6%)
Query: 85 HESVVKIW---IGPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKP--WLGNGLLISTG 139
H+ K+W G + ++ + DP ++ +L Y R F P ++ + + I+
Sbjct: 65 HKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKSAISIAED 123
Query: 140 QKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASN---FDCHDYMSECTVEI 196
++W+ R L++PTF LK + + +V L++EA D ++++
Sbjct: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 183
Query: 197 LLETAMGVS 205
+ T+ GV+
Sbjct: 184 ITSTSFGVN 192
>BC101631-1|AAI01632.1| 503|Homo sapiens cytochrome P450, subfamily
IIIA, polypeptide 4 protein.
Length = 503
Score = 140 bits (339), Expect = 1e-32
Identities = 73/219 (33%), Positives = 125/219 (57%), Gaps = 9/219 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK R+ FL L+++S ++S A+SD E+ Q +F G++TT++ SF + + H
Sbjct: 265 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q K+ EE+D + + P T+ L+M+YL+ + ETLRL+P + R +++ +
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRS 496
NG IP G ++I +Y LHR P + P KF P+ F + N Y + PF +GPR+
Sbjct: 384 --NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 497 CVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQADI 535
C+G ++A++ +K+ L +L+NF KE+ L+ +
Sbjct: 442 CIGMRFALMNMKLALIRVLQNFS-FKPCKETQIPLKLSL 479
Score = 39.5 bits (88), Expect = 0.030
Identities = 28/129 (21%), Positives = 59/129 (45%), Gaps = 9/129 (6%)
Query: 85 HESVVKIW---IGPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKP--WLGNGLLISTG 139
H+ K+W G + ++ + DP ++ +L Y R F P ++ + + I+
Sbjct: 65 HKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKSAISIAED 123
Query: 140 QKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASN---FDCHDYMSECTVEI 196
++W+ R L++PTF LK + + +V L++EA D ++++
Sbjct: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 183
Query: 197 LLETAMGVS 205
+ T+ GV+
Sbjct: 184 ITSTSFGVN 192
>BC069418-1|AAH69418.1| 503|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 4 protein.
Length = 503
Score = 140 bits (339), Expect = 1e-32
Identities = 73/219 (33%), Positives = 125/219 (57%), Gaps = 9/219 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK R+ FL L+++S ++S A+SD E+ Q +F G++TT++ SF + + H
Sbjct: 265 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q K+ EE+D + + P T+ L+M+YL+ + ETLRL+P + R +++ +
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRS 496
NG IP G ++I +Y LHR P + P KF P+ F + N Y + PF +GPR+
Sbjct: 384 --NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 497 CVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQADI 535
C+G ++A++ +K+ L +L+NF KE+ L+ +
Sbjct: 442 CIGMRFALMNMKLALIRVLQNFS-FKPCKETQIPLKLSL 479
Score = 39.5 bits (88), Expect = 0.030
Identities = 28/129 (21%), Positives = 59/129 (45%), Gaps = 9/129 (6%)
Query: 85 HESVVKIW---IGPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKP--WLGNGLLISTG 139
H+ K+W G + ++ + DP ++ +L Y R F P ++ + + I+
Sbjct: 65 HKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKSAISIAED 123
Query: 140 QKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASN---FDCHDYMSECTVEI 196
++W+ R L++PTF LK + + +V L++EA D ++++
Sbjct: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 183
Query: 197 LLETAMGVS 205
+ T+ GV+
Sbjct: 184 ITSTSFGVN 192
>AJ563377-1|CAD91345.1| 353|Homo sapiens cytochrome P450 protein.
Length = 353
Score = 140 bits (339), Expect = 1e-32
Identities = 73/219 (33%), Positives = 125/219 (57%), Gaps = 9/219 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK R+ FL L+++S ++S A+SD E+ Q +F G++TT++ SF + + H
Sbjct: 115 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 174
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q K+ EE+D + + P T+ L+M+YL+ + ETLRL+P + R +++ +
Sbjct: 175 PDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 233
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRS 496
NG IP G ++I +Y LHR P + P KF P+ F + N Y + PF +GPR+
Sbjct: 234 --NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 291
Query: 497 CVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQADI 535
C+G ++A++ +K+ L +L+NF KE+ L+ +
Sbjct: 292 CIGMRFALMNMKLALIRVLQNFS-FKPCKETQIPLKLSL 329
>AJ563376-2|CAD91645.1| 430|Homo sapiens cytochrome P450 protein.
Length = 430
Score = 140 bits (339), Expect = 1e-32
Identities = 73/219 (33%), Positives = 125/219 (57%), Gaps = 9/219 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK R+ FL L+++S ++S A+SD E+ Q +F G++TT++ SF + + H
Sbjct: 192 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 251
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q K+ EE+D + + P T+ L+M+YL+ + ETLRL+P + R +++ +
Sbjct: 252 PDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 310
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRS 496
NG IP G ++I +Y LHR P + P KF P+ F + N Y + PF +GPR+
Sbjct: 311 --NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 368
Query: 497 CVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQADI 535
C+G ++A++ +K+ L +L+NF KE+ L+ +
Sbjct: 369 CIGMRFALMNMKLALIRVLQNFS-FKPCKETQIPLKLSL 406
Score = 37.1 bits (82), Expect = 0.16
Identities = 25/117 (21%), Positives = 54/117 (46%), Gaps = 6/117 (5%)
Query: 94 GPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKP--WLGNGLLISTGQKWRSHRKLIAP 151
G + ++ + DP ++ +L Y R F P ++ + + I+ ++W+ R L++P
Sbjct: 4 GQQPVLAITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSP 62
Query: 152 TFHLNVLKSFIDLFNANSRAVVDKLKKEASN---FDCHDYMSECTVEILLETAMGVS 205
TF LK + + +V L++EA D +++++ T+ GV+
Sbjct: 63 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVN 119
>AJ563375-1|CAD91343.1| 503|Homo sapiens cytochrome P450 protein.
Length = 503
Score = 140 bits (339), Expect = 1e-32
Identities = 73/219 (33%), Positives = 125/219 (57%), Gaps = 9/219 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK R+ FL L+++S ++S A+SD E+ Q +F G++TT++ SF + + H
Sbjct: 265 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q K+ EE+D + + P T+ L+M+YL+ + ETLRL+P + R +++ +
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRS 496
NG IP G ++I +Y LHR P + P KF P+ F + N Y + PF +GPR+
Sbjct: 384 --NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 497 CVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQADI 535
C+G ++A++ +K+ L +L+NF KE+ L+ +
Sbjct: 442 CIGMRFALMNMKLALIRVLQNFS-FKPCKETQIPLKLSL 479
Score = 39.5 bits (88), Expect = 0.030
Identities = 28/129 (21%), Positives = 59/129 (45%), Gaps = 9/129 (6%)
Query: 85 HESVVKIW---IGPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKP--WLGNGLLISTG 139
H+ K+W G + ++ + DP ++ +L Y R F P ++ + + I+
Sbjct: 65 HKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKSAISIAED 123
Query: 140 QKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASN---FDCHDYMSECTVEI 196
++W+ R L++PTF LK + + +V L++EA D ++++
Sbjct: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 183
Query: 197 LLETAMGVS 205
+ T+ GV+
Sbjct: 184 ITSTSFGVN 192
>AF280107-2|AAG32290.1| 503|Homo sapiens cytochrome P450
polypeptide 4 protein.
Length = 503
Score = 140 bits (339), Expect = 1e-32
Identities = 73/219 (33%), Positives = 125/219 (57%), Gaps = 9/219 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK R+ FL L+++S ++S A+SD E+ Q +F G++TT++ SF + + H
Sbjct: 265 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q K+ EE+D + + P T+ L+M+YL+ + ETLRL+P + R +++ +
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRS 496
NG IP G ++I +Y LHR P + P KF P+ F + N Y + PF +GPR+
Sbjct: 384 --NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 497 CVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQADI 535
C+G ++A++ +K+ L +L+NF KE+ L+ +
Sbjct: 442 CIGMRFALMNMKLALIRVLQNFS-FKPCKETQIPLKLSL 479
Score = 39.5 bits (88), Expect = 0.030
Identities = 28/129 (21%), Positives = 59/129 (45%), Gaps = 9/129 (6%)
Query: 85 HESVVKIW---IGPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKP--WLGNGLLISTG 139
H+ K+W G + ++ + DP ++ +L Y R F P ++ + + I+
Sbjct: 65 HKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKSAISIAED 123
Query: 140 QKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASN---FDCHDYMSECTVEI 196
++W+ R L++PTF LK + + +V L++EA D ++++
Sbjct: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 183
Query: 197 LLETAMGVS 205
+ T+ GV+
Sbjct: 184 ITSTSFGVN 192
>AF209389-1|AAF21034.1| 503|Homo sapiens cytochrome P450 IIIA4
protein.
Length = 503
Score = 140 bits (339), Expect = 1e-32
Identities = 73/219 (33%), Positives = 125/219 (57%), Gaps = 9/219 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK R+ FL L+++S ++S A+SD E+ Q +F G++TT++ SF + + H
Sbjct: 265 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q K+ EE+D + + P T+ L+M+YL+ + ETLRL+P + R +++ +
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRS 496
NG IP G ++I +Y LHR P + P KF P+ F + N Y + PF +GPR+
Sbjct: 384 --NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 497 CVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQADI 535
C+G ++A++ +K+ L +L+NF KE+ L+ +
Sbjct: 442 CIGMRFALMNMKLALIRVLQNFS-FKPCKETQIPLKLSL 479
Score = 39.5 bits (88), Expect = 0.030
Identities = 28/129 (21%), Positives = 59/129 (45%), Gaps = 9/129 (6%)
Query: 85 HESVVKIW---IGPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKP--WLGNGLLISTG 139
H+ K+W G + ++ + DP ++ +L Y R F P ++ + + I+
Sbjct: 65 HKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKSAISIAED 123
Query: 140 QKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASN---FDCHDYMSECTVEI 196
++W+ R L++PTF LK + + +V L++EA D ++++
Sbjct: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 183
Query: 197 LLETAMGVS 205
+ T+ GV+
Sbjct: 184 ITSTSFGVN 192
>M14096-1|AAA35744.1| 503|Homo sapiens protein ( Human cytochrome
P-450 nifedipine oxidase mRNA, complet cds. ).
Length = 503
Score = 140 bits (338), Expect = 2e-32
Identities = 73/219 (33%), Positives = 125/219 (57%), Gaps = 9/219 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK R+ FL L+++S ++S A+SD E+ Q +F G++TT++ SF + + H
Sbjct: 265 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q K+ EE+D + + P T+ L+M+YL+ + ETLRL+P + R +++ +
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRS 496
NG IP G ++I +Y LHR P + P KF P+ F + N Y + PF +GPR+
Sbjct: 384 --NGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYTYTPFGSGPRN 441
Query: 497 CVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQADI 535
C+G ++A++ +K+ L +L+NF KE+ L+ +
Sbjct: 442 CIGMRFALMNMKLALIRVLQNFS-FKPCKETQIPLKLSL 479
Score = 39.5 bits (88), Expect = 0.030
Identities = 28/129 (21%), Positives = 59/129 (45%), Gaps = 9/129 (6%)
Query: 85 HESVVKIW---IGPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKP--WLGNGLLISTG 139
H+ K+W G + ++ + DP ++ +L Y R F P ++ + + I+
Sbjct: 65 HKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKSAISIAED 123
Query: 140 QKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASN---FDCHDYMSECTVEI 196
++W+ R L++PTF LK + + +V L++EA D ++++
Sbjct: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 183
Query: 197 LLETAMGVS 205
+ T+ GV+
Sbjct: 184 ITSTSFGVN 192
>J04449-1|AAA35747.1| 502|Homo sapiens cytochrome P450 nifedipine
oxidase protein.
Length = 502
Score = 140 bits (338), Expect = 2e-32
Identities = 73/219 (33%), Positives = 125/219 (57%), Gaps = 9/219 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK R+ FL L+++S ++S A+SD E+ Q +F G++TT++ SF + + H
Sbjct: 264 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 323
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q K+ EE+D + + P T+ L+M+YL+ + ETLRL+P + R +++ +
Sbjct: 324 PDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 382
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRS 496
NG IP G ++I +Y LHR P + P KF P+ F + N Y + PF +GPR+
Sbjct: 383 --NGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYTYTPFGSGPRN 440
Query: 497 CVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQADI 535
C+G ++A++ +K+ L +L+NF KE+ L+ +
Sbjct: 441 CIGMRFALMNMKLALIRVLQNFS-FKPCKETQIPLKLSL 478
Score = 37.1 bits (82), Expect = 0.16
Identities = 25/117 (21%), Positives = 54/117 (46%), Gaps = 6/117 (5%)
Query: 94 GPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKP--WLGNGLLISTGQKWRSHRKLIAP 151
G + ++ + DP ++ +L Y R F P ++ + + I+ ++W+ R L++P
Sbjct: 77 GQQPVLAITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSP 135
Query: 152 TFHLNVLKSFIDLFNANSRAVVDKLKKEASN---FDCHDYMSECTVEILLETAMGVS 205
TF LK + + +V L++EA D +++++ T+ GV+
Sbjct: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVN 192
>X12387-1|CAA30944.1| 503|Homo sapiens protein ( Human mRNA for
cytochrome P-450 (cyp3 locus). ).
Length = 503
Score = 139 bits (337), Expect = 2e-32
Identities = 73/219 (33%), Positives = 125/219 (57%), Gaps = 9/219 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK R+ FL L+++S ++S A+SD E+ Q +F G++TT++ SF + + H
Sbjct: 265 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q K+ EE+D + + P T+ L+M+YL+ + ETLRL+P + R +++ +
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRS 496
NG IP G ++I +Y LHR P + P KF P+ F + N Y + PF +GPR+
Sbjct: 384 --NGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 497 CVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQADI 535
C+G ++A++ +K+ L +L+NF KE+ L+ +
Sbjct: 442 CIGMRFALMNMKLALIRVLQNFS-FKPCKETQIPLKLSL 479
Score = 39.5 bits (88), Expect = 0.030
Identities = 28/129 (21%), Positives = 59/129 (45%), Gaps = 9/129 (6%)
Query: 85 HESVVKIW---IGPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKP--WLGNGLLISTG 139
H+ K+W G + ++ + DP ++ +L Y R F P ++ + + I+
Sbjct: 65 HKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKSAISIAED 123
Query: 140 QKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASN---FDCHDYMSECTVEI 196
++W+ R L++PTF LK + + +V L++EA D ++++
Sbjct: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 183
Query: 197 LLETAMGVS 205
+ T+ GV+
Sbjct: 184 ITSTSFGVN 192
>M13785-1|AAA35742.1| 504|Homo sapiens protein ( Human liver
glucocorticoid-inducible cytochrome P-450 (HLp) mRNA,
complete cds. ).
Length = 504
Score = 138 bits (335), Expect = 4e-32
Identities = 73/220 (33%), Positives = 125/220 (56%), Gaps = 10/220 (4%)
Query: 322 QKKRLAFLDLLLES------SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGI 375
QK R+ FL L+++S ++S A+SD E+ Q +F G++TT++ SF + +
Sbjct: 265 QKHRVDFLQLMIDSHKNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELAT 324
Query: 376 HQDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEIT 435
H D+Q K+ EE+D + + P T+ L+M+YL+ + ETLRL+P + R +++
Sbjct: 325 HPDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVE 383
Query: 436 LPSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPR 495
+ NG IP G ++I +Y LHR P + P KF P+ F + N Y + PF +GPR
Sbjct: 384 I--NGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPR 441
Query: 496 SCVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQADI 535
+C+G ++A++ +K+ L +L+NF KE+ L+ +
Sbjct: 442 NCIGMRFALMNMKLALIRVLQNFS-FKPCKETQIPLKLSL 480
Score = 34.7 bits (76), Expect = 0.86
Identities = 24/128 (18%), Positives = 57/128 (44%), Gaps = 7/128 (5%)
Query: 85 HESVVKIW---IGPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKP-WLGNGLLISTGQ 140
H+ K+W G + ++ + DP ++++L Y F ++ + + I+ +
Sbjct: 65 HKKYGKVWGFYDGQQPVLAITDPDMIKLVLVKECYSVFTNREPFGPVGFMKSAISIAEDE 124
Query: 141 KWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASN---FDCHDYMSECTVEIL 197
+W+ R L++PTF LK + + +V L++E D +++++
Sbjct: 125 EWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRRERETGKPVTLKDVFGAYSMDVI 184
Query: 198 LETAMGVS 205
++ GV+
Sbjct: 185 TSSSFGVN 192
>D00003-1|BAA00001.1| 504|Homo sapiens cytochrome P-450 protein.
Length = 504
Score = 138 bits (335), Expect = 4e-32
Identities = 73/220 (33%), Positives = 125/220 (56%), Gaps = 10/220 (4%)
Query: 322 QKKRLAFLDLLLES------SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGI 375
QK R+ FL L+++S ++S A+SD E+ Q +F G++TT++ SF + +
Sbjct: 265 QKHRVDFLQLMIDSHKNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELAT 324
Query: 376 HQDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEIT 435
H D+Q K+ EE+D + + P T+ L+M+YL+ + ETLRL+P + R +++
Sbjct: 325 HPDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVE 383
Query: 436 LPSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPR 495
+ NG IP G ++I +Y LHR P + P KF P+ F + N Y + PF +GPR
Sbjct: 384 I--NGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPR 441
Query: 496 SCVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQADI 535
+C+G ++A++ +K+ L +L+NF KE+ L+ +
Sbjct: 442 NCIGMRFALMNMKLALIRVLQNFS-FKPCKETQIPLKLSL 480
Score = 34.7 bits (76), Expect = 0.86
Identities = 24/128 (18%), Positives = 57/128 (44%), Gaps = 7/128 (5%)
Query: 85 HESVVKIW---IGPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKP-WLGNGLLISTGQ 140
H+ K+W G + ++ + DP ++++L Y F ++ + + I+ +
Sbjct: 65 HKKYGKVWGFYDGQQPVLAITDPDMIKLVLVKECYSVFTNREPFGPVGFMKSAISIAEDE 124
Query: 141 KWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASN---FDCHDYMSECTVEIL 197
+W+ R L++PTF LK + + +V L++E D +++++
Sbjct: 125 EWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRRERETGKPVTLKDVFGAYSMDVI 184
Query: 198 LETAMGVS 205
++ GV+
Sbjct: 185 TSSSFGVN 192
>AF182273-1|AAF13598.1| 503|Homo sapiens cytochrome P450-3A4
protein.
Length = 503
Score = 138 bits (334), Expect = 5e-32
Identities = 73/219 (33%), Positives = 124/219 (56%), Gaps = 9/219 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK R+ FL L+++S ++S A+SD E+ Q +F G +TT++ SF + + H
Sbjct: 265 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGCETTSSVLSFIMYELATH 324
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q K+ EE+D + + P T+ L+M+YL+ + ETLRL+P + R +++ +
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRS 496
NG IP G ++I +Y LHR P + P KF P+ F + N Y + PF +GPR+
Sbjct: 384 --NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 497 CVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQADI 535
C+G ++A++ +K+ L +L+NF KE+ L+ +
Sbjct: 442 CIGMRFALMNMKLALIRVLQNFS-FKPCKETQIPLKLSL 479
Score = 39.5 bits (88), Expect = 0.030
Identities = 28/129 (21%), Positives = 59/129 (45%), Gaps = 9/129 (6%)
Query: 85 HESVVKIW---IGPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKP--WLGNGLLISTG 139
H+ K+W G + ++ + DP ++ +L Y R F P ++ + + I+
Sbjct: 65 HKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKSAISIAED 123
Query: 140 QKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASN---FDCHDYMSECTVEI 196
++W+ R L++PTF LK + + +V L++EA D ++++
Sbjct: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 183
Query: 197 LLETAMGVS 205
+ T+ GV+
Sbjct: 184 ITSTSFGVN 192
>D00408-1|BAA00310.1| 503|Homo sapiens cytochrome P-450 HFLa
protein.
Length = 503
Score = 136 bits (329), Expect = 2e-31
Identities = 71/216 (32%), Positives = 123/216 (56%), Gaps = 9/216 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK R+ FL L+++S S++ A+SD E+ Q +F G++TT++ SF + + H
Sbjct: 265 QKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATH 324
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q KV +E+D + + P T+ L+++YL+ + ETLRL+P + R +++ +
Sbjct: 325 PDVQQKVQKEIDTVLPNK-APPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEI 383
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRS 496
NG IP G ++I +Y LH P + P KF P+ F + N Y + PF +GPR+
Sbjct: 384 --NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 497 CVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQ 532
C+G ++A++ +K+ L +L+NF KE+ L+
Sbjct: 442 CIGMRFALVNMKLALVRVLQNFS-FKPCKETQIPLK 476
Score = 36.7 bits (81), Expect = 0.21
Identities = 25/113 (22%), Positives = 51/113 (45%), Gaps = 6/113 (5%)
Query: 98 LVFLYDPRDVEVILSSHVYIDKAEEYRFFKP--WLGNGLLISTGQKWRSHRKLIAPTFHL 155
++ + DP ++ +L Y R F P ++ N + I+ ++W+ R L++PTF
Sbjct: 81 MLAITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTS 139
Query: 156 NVLKSFIDLFNANSRAVVDKLKKEASN---FDCHDYMSECTVEILLETAMGVS 205
LK + + +V L++EA +++++ T+ GVS
Sbjct: 140 GKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVS 192
>BC067436-1|AAH67436.1| 503|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 7 protein.
Length = 503
Score = 136 bits (329), Expect = 2e-31
Identities = 71/216 (32%), Positives = 123/216 (56%), Gaps = 9/216 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK R+ FL L+++S S++ A+SD E+ Q +F G++TT++ SF + + H
Sbjct: 265 QKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATH 324
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q KV +E+D + + P T+ L+++YL+ + ETLRL+P + R +++ +
Sbjct: 325 PDVQQKVQKEIDTVLPNK-APPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEI 383
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRS 496
NG IP G ++I +Y LH P + P KF P+ F + N Y + PF +GPR+
Sbjct: 384 --NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 497 CVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQ 532
C+G ++A++ +K+ L +L+NF KE+ L+
Sbjct: 442 CIGMRFALVNMKLALVRVLQNFS-FKPCKETQIPLK 476
Score = 36.7 bits (81), Expect = 0.21
Identities = 25/113 (22%), Positives = 51/113 (45%), Gaps = 6/113 (5%)
Query: 98 LVFLYDPRDVEVILSSHVYIDKAEEYRFFKP--WLGNGLLISTGQKWRSHRKLIAPTFHL 155
++ + DP ++ +L Y R F P ++ N + I+ ++W+ R L++PTF
Sbjct: 81 MLAITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTS 139
Query: 156 NVLKSFIDLFNANSRAVVDKLKKEASN---FDCHDYMSECTVEILLETAMGVS 205
LK + + +V L++EA +++++ T+ GVS
Sbjct: 140 GKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVS 192
>AF315325-1|AAG48618.1| 535|Homo sapiens cytochrome P450 variant
3A7 protein.
Length = 535
Score = 136 bits (329), Expect = 2e-31
Identities = 71/216 (32%), Positives = 123/216 (56%), Gaps = 9/216 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK R+ FL L+++S S++ A+SD E+ Q +F G++TT++ SF + + H
Sbjct: 265 QKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATH 324
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q KV +E+D + + P T+ L+++YL+ + ETLRL+P + R +++ +
Sbjct: 325 PDVQQKVQKEIDTVLPNK-APPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEI 383
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRS 496
NG IP G ++I +Y LH P + P KF P+ F + N Y + PF +GPR+
Sbjct: 384 --NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 497 CVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQ 532
C+G ++A++ +K+ L +L+NF KE+ L+
Sbjct: 442 CIGMRFALVNMKLALVRVLQNFS-FKPCKETQIPLK 476
Score = 36.7 bits (81), Expect = 0.21
Identities = 25/113 (22%), Positives = 51/113 (45%), Gaps = 6/113 (5%)
Query: 98 LVFLYDPRDVEVILSSHVYIDKAEEYRFFKP--WLGNGLLISTGQKWRSHRKLIAPTFHL 155
++ + DP ++ +L Y R F P ++ N + I+ ++W+ R L++PTF
Sbjct: 81 MLAITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTS 139
Query: 156 NVLKSFIDLFNANSRAVVDKLKKEASN---FDCHDYMSECTVEILLETAMGVS 205
LK + + +V L++EA +++++ T+ GVS
Sbjct: 140 GKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVS 192
>AF280107-3|AAG32289.1| 503|Homo sapiens cytochrome P450
polypeptide 7 protein.
Length = 503
Score = 136 bits (329), Expect = 2e-31
Identities = 71/216 (32%), Positives = 123/216 (56%), Gaps = 9/216 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK R+ FL L+++S S++ A+SD E+ Q +F G++TT++ SF + + H
Sbjct: 265 QKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATH 324
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q KV +E+D + + P T+ L+++YL+ + ETLRL+P + R +++ +
Sbjct: 325 PDVQQKVQKEIDTVLPNK-APPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEI 383
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRS 496
NG IP G ++I +Y LH P + P KF P+ F + N Y + PF +GPR+
Sbjct: 384 --NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 497 CVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQ 532
C+G ++A++ +K+ L +L+NF KE+ L+
Sbjct: 442 CIGMRFALVNMKLALVRVLQNFS-FKPCKETQIPLK 476
Score = 36.7 bits (81), Expect = 0.21
Identities = 25/113 (22%), Positives = 51/113 (45%), Gaps = 6/113 (5%)
Query: 98 LVFLYDPRDVEVILSSHVYIDKAEEYRFFKP--WLGNGLLISTGQKWRSHRKLIAPTFHL 155
++ + DP ++ +L Y R F P ++ N + I+ ++W+ R L++PTF
Sbjct: 81 MLAITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTS 139
Query: 156 NVLKSFIDLFNANSRAVVDKLKKEASN---FDCHDYMSECTVEILLETAMGVS 205
LK + + +V L++EA +++++ T+ GVS
Sbjct: 140 GKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVS 192
>J04813-1|AAA02993.1| 502|Homo sapiens cytochrome P450 PCN3
protein.
Length = 502
Score = 135 bits (326), Expect = 4e-31
Identities = 73/218 (33%), Positives = 125/218 (57%), Gaps = 10/218 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK RL FL L+++S ++S A+SD E+ Q +F G++TT++ SF L + H
Sbjct: 265 QKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATH 324
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q K+ +E+D + + P T+ ++M+YL+ + ETLRL+P + R +++ +
Sbjct: 325 PDVQQKLQKEIDAVLPNK-APPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI 383
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRS 496
NG IP G+ +VI TY LH P + P +F P+ F ++ + Y + PF GPR+
Sbjct: 384 --NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYI-YTPFGTGPRN 440
Query: 497 CVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQAD 534
C+G ++A++ +K+ L +L+NF KE+ L+ D
Sbjct: 441 CIGMRFALMNMKLALIRVLQNFS-FKPCKETQIPLKLD 477
Score = 31.5 bits (68), Expect = 8.0
Identities = 16/80 (20%), Positives = 38/80 (47%), Gaps = 3/80 (3%)
Query: 129 WLGNGLLISTGQKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASN---FDC 185
++ + + ++ ++W+ R L++PTF LK + +V L++EA
Sbjct: 113 FMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTL 172
Query: 186 HDYMSECTVEILLETAMGVS 205
D +++++ T+ GV+
Sbjct: 173 KDIFGAYSMDVITGTSFGVN 192
>BC033862-1|AAH33862.1| 502|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 5 protein.
Length = 502
Score = 135 bits (326), Expect = 4e-31
Identities = 73/218 (33%), Positives = 125/218 (57%), Gaps = 10/218 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK RL FL L+++S ++S A+SD E+ Q +F G++TT++ SF L + H
Sbjct: 265 QKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATH 324
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q K+ +E+D + + P T+ ++M+YL+ + ETLRL+P + R +++ +
Sbjct: 325 PDVQQKLQKEIDAVLPNK-APPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI 383
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRS 496
NG IP G+ +VI TY LH P + P +F P+ F ++ + Y + PF GPR+
Sbjct: 384 --NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYI-YTPFGTGPRN 440
Query: 497 CVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQAD 534
C+G ++A++ +K+ L +L+NF KE+ L+ D
Sbjct: 441 CIGMRFALMNMKLALIRVLQNFS-FKPCKETQIPLKLD 477
Score = 31.5 bits (68), Expect = 8.0
Identities = 16/80 (20%), Positives = 38/80 (47%), Gaps = 3/80 (3%)
Query: 129 WLGNGLLISTGQKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASN---FDC 185
++ + + ++ ++W+ R L++PTF LK + +V L++EA
Sbjct: 113 FMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTL 172
Query: 186 HDYMSECTVEILLETAMGVS 205
D +++++ T+ GV+
Sbjct: 173 KDIFGAYSMDVITGTSFGVN 192
>AC005020-1|AAS02016.1| 502|Homo sapiens unknown protein.
Length = 502
Score = 135 bits (326), Expect = 4e-31
Identities = 73/218 (33%), Positives = 125/218 (57%), Gaps = 10/218 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK RL FL L+++S ++S A+SD E+ Q +F G++TT++ SF L + H
Sbjct: 265 QKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATH 324
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q K+ +E+D + + P T+ ++M+YL+ + ETLRL+P + R +++ +
Sbjct: 325 PDVQQKLQKEIDAVLPNK-APPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI 383
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRS 496
NG IP G+ +VI TY LH P + P +F P+ F ++ + Y + PF GPR+
Sbjct: 384 --NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYI-YTPFGTGPRN 440
Query: 497 CVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQAD 534
C+G ++A++ +K+ L +L+NF KE+ L+ D
Sbjct: 441 CIGMRFALMNMKLALIRVLQNFS-FKPCKETQIPLKLD 477
Score = 31.5 bits (68), Expect = 8.0
Identities = 16/80 (20%), Positives = 38/80 (47%), Gaps = 3/80 (3%)
Query: 129 WLGNGLLISTGQKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASN---FDC 185
++ + + ++ ++W+ R L++PTF LK + +V L++EA
Sbjct: 113 FMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTL 172
Query: 186 HDYMSECTVEILLETAMGVS 205
D +++++ T+ GV+
Sbjct: 173 KDIFGAYSMDVITGTSFGVN 192
>AY390424-1|AAQ92352.1| 503|Homo sapiens cytochrome P450 CYP3A43.3
protein.
Length = 503
Score = 134 bits (325), Expect = 6e-31
Identities = 71/218 (32%), Positives = 120/218 (55%), Gaps = 9/218 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK R+ F +++S ++S A+SD E+ Q I+F +DTT+ F + + H
Sbjct: 265 QKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATH 324
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q K+ EE+D + + PVT+ ++M+YL+ + ETLRL+P V + R ++I +
Sbjct: 325 PDVQQKLQEEIDAVLANK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI 383
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRS 496
NG IP G +++ Y LH P + P KF P+ F + + Y ++PF AGPR+
Sbjct: 384 --NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRN 441
Query: 497 CVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQAD 534
C+G ++A+ +K+ + L+NF KE+ L+ D
Sbjct: 442 CIGMRFALTNIKLAVIRALQNFS-FKPCKETQIPLKLD 478
Score = 35.9 bits (79), Expect = 0.37
Identities = 23/119 (19%), Positives = 54/119 (45%), Gaps = 4/119 (3%)
Query: 91 IWIGPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKP-WLGNGLLISTGQKWRSHRKLI 149
++ G + ++ + DP ++ +L Y + +L + L + ++W+ R L+
Sbjct: 74 LYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLL 133
Query: 150 APTFHLNVLKSFIDLFNANSRAVVDKLKKEASN---FDCHDYMSECTVEILLETAMGVS 205
+P F K + + + +V L++EA N + D+ T++++ T GV+
Sbjct: 134 SPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVN 192
>AK223008-1|BAD96728.1| 502|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 5 variant protein.
Length = 502
Score = 134 bits (324), Expect = 8e-31
Identities = 73/218 (33%), Positives = 125/218 (57%), Gaps = 10/218 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK RL FL L+++S ++S A+SD E+ Q +F G++TT++ SF L + H
Sbjct: 265 QKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATH 324
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q K+ +E+D + + P T+ ++M+YL+ + ETLRL+P + R +++ +
Sbjct: 325 PDVQQKLQKEIDAVLPNK-APPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCMKDVEI 383
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRS 496
NG IP G+ +VI TY LH P + P +F P+ F ++ + Y + PF GPR+
Sbjct: 384 --NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYI-YTPFGTGPRN 440
Query: 497 CVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQAD 534
C+G ++A++ +K+ L +L+NF KE+ L+ D
Sbjct: 441 CIGMRFALMNMKLALIRVLQNFS-FKPCKETQIPLKLD 477
>BC100981-1|AAI00982.1| 393|Homo sapiens CYP3A43 protein protein.
Length = 393
Score = 134 bits (323), Expect = 1e-30
Identities = 71/218 (32%), Positives = 120/218 (55%), Gaps = 9/218 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK R+ F +++S ++S A+SD E+ Q I+F +DTT+ F + + H
Sbjct: 155 QKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATH 214
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q K+ EE+D + + PVT+ ++M+YL+ + ETLRL+P V + R ++I +
Sbjct: 215 PDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI 273
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRS 496
NG IP G +++ Y LH P + P KF P+ F + + Y ++PF AGPR+
Sbjct: 274 --NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRN 331
Query: 497 CVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQAD 534
C+G ++A+ +K+ + L+NF KE+ L+ D
Sbjct: 332 CIGMRFALTNIKLAVIRALQNFS-FKPCKETQIPLKLD 368
>AY390425-1|AAQ92353.1| 503|Homo sapiens cytochrome P450 CYP3A43.1
protein.
Length = 503
Score = 134 bits (323), Expect = 1e-30
Identities = 71/218 (32%), Positives = 120/218 (55%), Gaps = 9/218 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK R+ F +++S ++S A+SD E+ Q I+F +DTT+ F + + H
Sbjct: 265 QKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATH 324
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q K+ EE+D + + PVT+ ++M+YL+ + ETLRL+P V + R ++I +
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI 383
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRS 496
NG IP G +++ Y LH P + P KF P+ F + + Y ++PF AGPR+
Sbjct: 384 --NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRN 441
Query: 497 CVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQAD 534
C+G ++A+ +K+ + L+NF KE+ L+ D
Sbjct: 442 CIGMRFALTNIKLAVIRALQNFS-FKPCKETQIPLKLD 478
Score = 35.9 bits (79), Expect = 0.37
Identities = 23/119 (19%), Positives = 54/119 (45%), Gaps = 4/119 (3%)
Query: 91 IWIGPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKP-WLGNGLLISTGQKWRSHRKLI 149
++ G + ++ + DP ++ +L Y + +L + L + ++W+ R L+
Sbjct: 74 LYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLL 133
Query: 150 APTFHLNVLKSFIDLFNANSRAVVDKLKKEASN---FDCHDYMSECTVEILLETAMGVS 205
+P F K + + + +V L++EA N + D+ T++++ T GV+
Sbjct: 134 SPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVN 192
>AF337813-1|AAK38841.1| 503|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 503
Score = 134 bits (323), Expect = 1e-30
Identities = 71/218 (32%), Positives = 120/218 (55%), Gaps = 9/218 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK R+ F +++S ++S A+SD E+ Q I+F +DTT+ F + + H
Sbjct: 265 QKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATH 324
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q K+ EE+D + + PVT+ ++M+YL+ + ETLRL+P V + R ++I +
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI 383
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRS 496
NG IP G +++ Y LH P + P KF P+ F + + Y ++PF AGPR+
Sbjct: 384 --NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRN 441
Query: 497 CVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQAD 534
C+G ++A+ +K+ + L+NF KE+ L+ D
Sbjct: 442 CIGMRFALTNIKLAVIRALQNFS-FKPCKETQIPLKLD 478
Score = 35.9 bits (79), Expect = 0.37
Identities = 23/119 (19%), Positives = 54/119 (45%), Gaps = 4/119 (3%)
Query: 91 IWIGPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKP-WLGNGLLISTGQKWRSHRKLI 149
++ G + ++ + DP ++ +L Y + +L + L + ++W+ R L+
Sbjct: 74 LYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLL 133
Query: 150 APTFHLNVLKSFIDLFNANSRAVVDKLKKEASN---FDCHDYMSECTVEILLETAMGVS 205
+P F K + + + +V L++EA N + D+ T++++ T GV+
Sbjct: 134 SPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVN 192
>AF319634-1|AAK00325.1| 503|Homo sapiens cytochrome P450 CYP3A43
protein.
Length = 503
Score = 134 bits (323), Expect = 1e-30
Identities = 71/218 (32%), Positives = 120/218 (55%), Gaps = 9/218 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK R+ F +++S ++S A+SD E+ Q I+F +DTT+ F + + H
Sbjct: 265 QKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATH 324
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q K+ EE+D + + PVT+ ++M+YL+ + ETLRL+P V + R ++I +
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI 383
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRS 496
NG IP G +++ Y LH P + P KF P+ F + + Y ++PF AGPR+
Sbjct: 384 --NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRN 441
Query: 497 CVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQAD 534
C+G ++A+ +K+ + L+NF KE+ L+ D
Sbjct: 442 CIGMRFALTNIKLAVIRALQNFS-FKPCKETQIPLKLD 478
Score = 35.9 bits (79), Expect = 0.37
Identities = 23/119 (19%), Positives = 54/119 (45%), Gaps = 4/119 (3%)
Query: 91 IWIGPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKP-WLGNGLLISTGQKWRSHRKLI 149
++ G + ++ + DP ++ +L Y + +L + L + ++W+ R L+
Sbjct: 74 LYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLL 133
Query: 150 APTFHLNVLKSFIDLFNANSRAVVDKLKKEASN---FDCHDYMSECTVEILLETAMGVS 205
+P F K + + + +V L++EA N + D+ T++++ T GV+
Sbjct: 134 SPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVN 192
>AF280108-1|AAG33009.1| 503|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 503
Score = 134 bits (323), Expect = 1e-30
Identities = 71/218 (32%), Positives = 120/218 (55%), Gaps = 9/218 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK R+ F +++S ++S A+SD E+ Q I+F +DTT+ F + + H
Sbjct: 265 QKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATH 324
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q K+ EE+D + + PVT+ ++M+YL+ + ETLRL+P V + R ++I +
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI 383
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRS 496
NG IP G +++ Y LH P + P KF P+ F + + Y ++PF AGPR+
Sbjct: 384 --NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRN 441
Query: 497 CVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQAD 534
C+G ++A+ +K+ + L+NF KE+ L+ D
Sbjct: 442 CIGMRFALTNIKLAVIRALQNFS-FKPCKETQIPLKLD 478
Score = 35.9 bits (79), Expect = 0.37
Identities = 23/119 (19%), Positives = 54/119 (45%), Gaps = 4/119 (3%)
Query: 91 IWIGPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKP-WLGNGLLISTGQKWRSHRKLI 149
++ G + ++ + DP ++ +L Y + +L + L + ++W+ R L+
Sbjct: 74 LYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLL 133
Query: 150 APTFHLNVLKSFIDLFNANSRAVVDKLKKEASN---FDCHDYMSECTVEILLETAMGVS 205
+P F K + + + +V L++EA N + D+ T++++ T GV+
Sbjct: 134 SPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVN 192
>AC011904-4|AAS07395.1| 503|Homo sapiens unknown protein.
Length = 503
Score = 134 bits (323), Expect = 1e-30
Identities = 71/218 (32%), Positives = 120/218 (55%), Gaps = 9/218 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK R+ F +++S ++S A+SD E+ Q I+F +DTT+ F + + H
Sbjct: 265 QKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATH 324
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q K+ EE+D + + PVT+ ++M+YL+ + ETLRL+P V + R ++I +
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI 383
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRS 496
NG IP G +++ Y LH P + P KF P+ F + + Y ++PF AGPR+
Sbjct: 384 --NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRN 441
Query: 497 CVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQAD 534
C+G ++A+ +K+ + L+NF KE+ L+ D
Sbjct: 442 CIGMRFALTNIKLAVIRALQNFS-FKPCKETQIPLKLD 478
Score = 35.9 bits (79), Expect = 0.37
Identities = 23/119 (19%), Positives = 54/119 (45%), Gaps = 4/119 (3%)
Query: 91 IWIGPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKP-WLGNGLLISTGQKWRSHRKLI 149
++ G + ++ + DP ++ +L Y + +L + L + ++W+ R L+
Sbjct: 74 LYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLL 133
Query: 150 APTFHLNVLKSFIDLFNANSRAVVDKLKKEASN---FDCHDYMSECTVEILLETAMGVS 205
+P F K + + + +V L++EA N + D+ T++++ T GV+
Sbjct: 134 SPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVN 192
>X71480-1|CAA50586.1| 141|Homo sapiens cytochrome P450 protein.
Length = 141
Score = 133 bits (322), Expect = 1e-30
Identities = 62/145 (42%), Positives = 91/145 (62%), Gaps = 4/145 (2%)
Query: 353 TIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERC 412
T MFEGHDTTA+G S+ L + H Q++ EE+ + GD +T+ +M Y C
Sbjct: 1 TFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDG-ASITWNHLDQMPYTTMC 59
Query: 413 LMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPD 472
+ E LRLYPPVP I+R+++ +T P +G+ +P G T++++ Y LH P V+PNP FDP
Sbjct: 60 IKEALRLYPPVPGISRELSTPVTFP-DGRSLPKGITVMLSIYGLHHNPKVWPNPEVFDPS 118
Query: 473 NFLPERSANRHYYAFVPFSAGPRSC 497
F P + +H +AF+PFS G R+C
Sbjct: 119 RFAP--GSAQHSHAFLPFSGGSRNC 141
>AF280109-1|AAG33010.1| 504|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 504
Score = 130 bits (313), Expect = 2e-29
Identities = 71/219 (32%), Positives = 121/219 (55%), Gaps = 10/219 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK R+ F +++S ++S A+SD E+ Q I+F +DTT+ F + + H
Sbjct: 265 QKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATH 324
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q K+ EE+D + + PVT+ ++M+YL+ + ETLRL+P V + R ++I +
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI 383
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDN-FLPERSANRHYYAFVPFSAGPR 495
NG IP G +++ Y LH P + P KF P++ F + + Y ++PF AGPR
Sbjct: 384 --NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGPR 441
Query: 496 SCVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQAD 534
+C+G ++A+ +K+ + L+NF KE+ L+ D
Sbjct: 442 NCIGMRFALTNIKLAVIRALQNFS-FKPCKETQIPLKLD 479
Score = 35.9 bits (79), Expect = 0.37
Identities = 23/119 (19%), Positives = 54/119 (45%), Gaps = 4/119 (3%)
Query: 91 IWIGPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKP-WLGNGLLISTGQKWRSHRKLI 149
++ G + ++ + DP ++ +L Y + +L + L + ++W+ R L+
Sbjct: 74 LYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLL 133
Query: 150 APTFHLNVLKSFIDLFNANSRAVVDKLKKEASN---FDCHDYMSECTVEILLETAMGVS 205
+P F K + + + +V L++EA N + D+ T++++ T GV+
Sbjct: 134 SPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVN 192
>AC011904-5|AAS07394.1| 504|Homo sapiens unknown protein.
Length = 504
Score = 130 bits (313), Expect = 2e-29
Identities = 71/219 (32%), Positives = 121/219 (55%), Gaps = 10/219 (4%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK R+ F +++S ++S A+SD E+ Q I+F +DTT+ F + + H
Sbjct: 265 QKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATH 324
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q K+ EE+D + + PVT+ ++M+YL+ + ETLRL+P V + R ++I +
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI 383
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDN-FLPERSANRHYYAFVPFSAGPR 495
NG IP G +++ Y LH P + P KF P++ F + + Y ++PF AGPR
Sbjct: 384 --NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGPR 441
Query: 496 SCVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQAD 534
+C+G ++A+ +K+ + L+NF KE+ L+ D
Sbjct: 442 NCIGMRFALTNIKLAVIRALQNFS-FKPCKETQIPLKLD 479
Score = 35.9 bits (79), Expect = 0.37
Identities = 23/119 (19%), Positives = 54/119 (45%), Gaps = 4/119 (3%)
Query: 91 IWIGPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKP-WLGNGLLISTGQKWRSHRKLI 149
++ G + ++ + DP ++ +L Y + +L + L + ++W+ R L+
Sbjct: 74 LYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLL 133
Query: 150 APTFHLNVLKSFIDLFNANSRAVVDKLKKEASN---FDCHDYMSECTVEILLETAMGVS 205
+P F K + + + +V L++EA N + D+ T++++ T GV+
Sbjct: 134 SPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVN 192
>AL135960-9|CAI19736.1| 421|Homo sapiens cytochrome P450, family 4,
subfamily A, polypeptide 22 protein.
Length = 421
Score = 116 bits (278), Expect = 3e-25
Identities = 55/144 (38%), Positives = 87/144 (60%), Gaps = 4/144 (2%)
Query: 405 EMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVYP 464
+M Y C+ E LRLYPPVP I R+++ +T P +G+ +P G ++++ Y LH P V+P
Sbjct: 270 QMPYTTMCIKEALRLYPPVPGIGRELSTPVTFP-DGRSLPKGIMVLLSIYGLHHNPKVWP 328
Query: 465 NPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVISDL 524
N FDP F P + +H +AF+PFS G R+C+G+++AM +LKV + L F ++ D
Sbjct: 329 NLEVFDPSRFAP--GSAQHSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDP 386
Query: 525 KESDFKLQADIILKRAEGFQVRLQ 548
+ A ++LK G +RL+
Sbjct: 387 TRIPIPM-ARLVLKSKNGIHLRLR 409
Score = 67.7 bits (158), Expect = 1e-10
Identities = 40/127 (31%), Positives = 67/127 (52%), Gaps = 5/127 (3%)
Query: 87 SVVKIWI-GPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKPWLGNGLLISTGQKWRSH 145
S WI G ++ V LYDP ++VIL Y+F P +G GLL+ GQ W H
Sbjct: 84 SACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGS-YKFLAPRIGYGLLLLNGQTWFQH 142
Query: 146 RKLIAPTFHLNVLKSFIDLFNANSRAVVDK---LKKEASNFDCHDYMSECTVEILLETAM 202
R+++ P FH ++LK ++ L + R ++DK L + S + ++S T++ ++++A
Sbjct: 143 RRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAF 202
Query: 203 GVSKSTQ 209
S Q
Sbjct: 203 SHQGSIQ 209
>BC022539-1|AAH22539.1| 500|Homo sapiens cytochrome P450, family
46, subfamily A, polypeptide 1 protein.
Length = 500
Score = 109 bits (263), Expect = 2e-23
Identities = 65/212 (30%), Positives = 116/212 (54%), Gaps = 10/212 (4%)
Query: 341 AISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTF 400
A DE + + T GH+T+A +F + + +I ++ E+D++ G S R + F
Sbjct: 286 AQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIG-SKRYLDF 344
Query: 401 QDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRP 460
+D ++YL + L E+LRLYPP R + +E + +G ++P T L+ +TY + R
Sbjct: 345 EDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLI--DGVRVPGNTPLLFSTYVMGRMD 402
Query: 461 DVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILR--NF 518
+ +P F+PD F P A + + + PFS G RSC+G+++A +++KV+++ +L+ F
Sbjct: 403 TYFEDPLTFNPDRFGP--GAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEF 460
Query: 519 RVISDLKESDFKLQADIILKRAEGFQVRLQPR 550
R++ + F LQ LK + L+PR
Sbjct: 461 RLVPGQR---FGLQEQATLKPLDPVLCTLRPR 489
Score = 39.9 bits (89), Expect = 0.023
Identities = 31/129 (24%), Positives = 59/129 (45%), Gaps = 9/129 (6%)
Query: 88 VVKIWIGPRLLVFLYDPRDVEVILSSHVYIDKAEEYR-----FFKPWLGNGLLISTG-QK 141
VV++ + + V + P V+ L S Y ++ YR F + G GL+ ++
Sbjct: 74 VVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYER 133
Query: 142 WRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASN---FDCHDYMSECTVEILL 198
W R++I F + L S ++ FN + +V+ L+ +A D ++ ++IL
Sbjct: 134 WHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILA 193
Query: 199 ETAMGVSKS 207
+ A G+ S
Sbjct: 194 KAAFGMETS 202
>AF094480-1|AAD41244.1| 500|Homo sapiens cholesterol 24-hydroxylase
protein.
Length = 500
Score = 109 bits (263), Expect = 2e-23
Identities = 65/212 (30%), Positives = 116/212 (54%), Gaps = 10/212 (4%)
Query: 341 AISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTF 400
A DE + + T GH+T+A +F + + +I ++ E+D++ G S R + F
Sbjct: 286 AQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIG-SKRYLDF 344
Query: 401 QDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRP 460
+D ++YL + L E+LRLYPP R + +E + +G ++P T L+ +TY + R
Sbjct: 345 EDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLI--DGVRVPGNTPLLFSTYVMGRMD 402
Query: 461 DVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILR--NF 518
+ +P F+PD F P A + + + PFS G RSC+G+++A +++KV+++ +L+ F
Sbjct: 403 TYFEDPLTFNPDRFGP--GAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEF 460
Query: 519 RVISDLKESDFKLQADIILKRAEGFQVRLQPR 550
R++ + F LQ LK + L+PR
Sbjct: 461 RLVPGQR---FGLQEQATLKPLDPVLCTLRPR 489
Score = 39.9 bits (89), Expect = 0.023
Identities = 31/129 (24%), Positives = 59/129 (45%), Gaps = 9/129 (6%)
Query: 88 VVKIWIGPRLLVFLYDPRDVEVILSSHVYIDKAEEYR-----FFKPWLGNGLLISTG-QK 141
VV++ + + V + P V+ L S Y ++ YR F + G GL+ ++
Sbjct: 74 VVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYER 133
Query: 142 WRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASN---FDCHDYMSECTVEILL 198
W R++I F + L S ++ FN + +V+ L+ +A D ++ ++IL
Sbjct: 134 WHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILA 193
Query: 199 ETAMGVSKS 207
+ A G+ S
Sbjct: 194 KAAFGMETS 202
>AF233624-1|AAF99278.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 106 bits (255), Expect = 2e-22
Identities = 56/176 (31%), Positives = 94/176 (53%), Gaps = 4/176 (2%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
+EI Q + G++ SF ++ + D Q+K++ E+D +F + F
Sbjct: 330 DEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVD-VFKEKHMAPEFCSLE 388
Query: 405 E-MKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVY 463
E + YL+ + ETLR+YPP R+ Q+ + G++IPAG L +A LH P+ +
Sbjct: 389 EGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL--GQRIPAGAVLEMAVGALHHDPEHW 446
Query: 464 PNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFR 519
P+P F+P+ F E + ++PF AGPRSC+G + +L++K+ L +L FR
Sbjct: 447 PSPENFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR 502
>M80647-1|AAA60618.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 106 bits (254), Expect = 2e-22
Identities = 56/176 (31%), Positives = 94/176 (53%), Gaps = 4/176 (2%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
+EI Q + G++ SF ++ + D Q+K++ E+D +F + F
Sbjct: 330 DEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVD-VFKEKHMAPEFCSLE 388
Query: 405 E-MKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVY 463
E + YL+ + ETLR+YPP R+ Q+ + G++IPAG L +A LH P+ +
Sbjct: 389 EGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL--GQRIPAGAVLEMAVGALHHDPEHW 446
Query: 464 PNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFR 519
P+P F+P+ F E + ++PF AGPRSC+G + +L++K+ L +L FR
Sbjct: 447 PSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR 502
>BC041157-1|AAH41157.1| 534|Homo sapiens thromboxane A synthase 1
(platelet, cytochrome P450, family 5, subfamily A)
protein.
Length = 534
Score = 106 bits (254), Expect = 2e-22
Identities = 56/176 (31%), Positives = 94/176 (53%), Gaps = 4/176 (2%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
+EI Q + G++ SF ++ + D Q+K++ E+D +F + F
Sbjct: 330 DEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVD-VFKEKHMAPEFCSLE 388
Query: 405 E-MKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVY 463
E + YL+ + ETLR+YPP R+ Q+ + G++IPAG L +A LH P+ +
Sbjct: 389 EGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL--GQRIPAGAVLEMAVGALHHDPEHW 446
Query: 464 PNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFR 519
P+P F+P+ F E + ++PF AGPRSC+G + +L++K+ L +L FR
Sbjct: 447 PSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR 502
>BC014117-1|AAH14117.1| 466|Homo sapiens TBXAS1 protein protein.
Length = 466
Score = 106 bits (254), Expect = 2e-22
Identities = 56/176 (31%), Positives = 94/176 (53%), Gaps = 4/176 (2%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
+EI Q + G++ SF ++ + D Q+K++ E+D +F + F
Sbjct: 262 DEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVD-VFKEKHMAPEFCSLE 320
Query: 405 E-MKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVY 463
E + YL+ + ETLR+YPP R+ Q+ + G++IPAG L +A LH P+ +
Sbjct: 321 EGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL--GQRIPAGAVLEMAVGALHHDPEHW 378
Query: 464 PNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFR 519
P+P F+P+ F E + ++PF AGPRSC+G + +L++K+ L +L FR
Sbjct: 379 PSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR 434
>AK223466-1|BAD97186.1| 534|Homo sapiens thromboxane A synthase 1
(platelet, cytochrome P450, family 5, subfamily A) iso
protein.
Length = 534
Score = 106 bits (254), Expect = 2e-22
Identities = 56/176 (31%), Positives = 94/176 (53%), Gaps = 4/176 (2%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
+EI Q + G++ SF ++ + D Q+K++ E+D +F + F
Sbjct: 330 DEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVD-VFKEKHMAPEFCSLE 388
Query: 405 E-MKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVY 463
E + YL+ + ETLR+YPP R+ Q+ + G++IPAG L +A LH P+ +
Sbjct: 389 EGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL--GQRIPAGAVLEMAVGALHHDPEHW 446
Query: 464 PNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFR 519
P+P F+P+ F E + ++PF AGPRSC+G + +L++K+ L +L FR
Sbjct: 447 PSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR 502
>AF233625-1|AAF99279.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 106 bits (254), Expect = 2e-22
Identities = 56/176 (31%), Positives = 94/176 (53%), Gaps = 4/176 (2%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
+EI Q + G++ SF ++ + D Q+K++ E+D +F + F
Sbjct: 330 DEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVD-VFKEKHMAPEFCSLE 388
Query: 405 E-MKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVY 463
E + YL+ + ETLR+YPP R+ Q+ + G++IPAG L +A LH P+ +
Sbjct: 389 EGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL--GQRIPAGAVLEMAVGALHHDPEHW 446
Query: 464 PNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFR 519
P+P F+P+ F E + ++PF AGPRSC+G + +L++K+ L +L FR
Sbjct: 447 PSPETFNPERFTAEARQQHQPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR 502
>AF233623-1|AAF99277.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 106 bits (254), Expect = 2e-22
Identities = 56/176 (31%), Positives = 94/176 (53%), Gaps = 4/176 (2%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
+EI Q + G++ SF ++ + D Q+K++ E+D +F + F
Sbjct: 330 DEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVD-VFKEKHMAPEFCSLE 388
Query: 405 E-MKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVY 463
E + YL+ + ETLR+YPP R+ Q+ + G++IPAG L +A LH P+ +
Sbjct: 389 EGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL--GQRIPAGAVLEMAVGALHHDPEHW 446
Query: 464 PNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFR 519
P+P F+P+ F E + ++PF AGPRSC+G + +L++K+ L +L FR
Sbjct: 447 PSPKTFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR 502
>AF233620-1|AAF99274.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 106 bits (254), Expect = 2e-22
Identities = 56/176 (31%), Positives = 94/176 (53%), Gaps = 4/176 (2%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
+EI Q + G++ SF ++ + D Q+K++ E+D +F + F
Sbjct: 330 DEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVD-VFKEKHMAPEFCSLE 388
Query: 405 E-MKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVY 463
E + YL+ + ETLR+YPP R+ Q+ + G++IPAG L +A LH P+ +
Sbjct: 389 EGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL--GQRIPAGAVLEMAVGALHHDPEHW 446
Query: 464 PNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFR 519
P+P F+P+ F E + ++PF AGPRSC+G + +L++K+ L +L FR
Sbjct: 447 PSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR 502
>AF233619-1|AAF99273.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 106 bits (254), Expect = 2e-22
Identities = 56/176 (31%), Positives = 94/176 (53%), Gaps = 4/176 (2%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
+EI Q + G++ SF ++ + D Q+K++ E+D +F + F
Sbjct: 330 DEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVD-VFKEKHMAPEFCSLE 388
Query: 405 E-MKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVY 463
E + YL+ + ETLR+YPP R+ Q+ + G++IPAG L +A LH P+ +
Sbjct: 389 EGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL--GQRIPAGAVLEMAVGALHHDPEHW 446
Query: 464 PNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFR 519
P+P F+P+ F E + ++PF AGPRSC+G + +L++K+ L +L FR
Sbjct: 447 PSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR 502
>AF233618-1|AAF99272.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 106 bits (254), Expect = 2e-22
Identities = 56/176 (31%), Positives = 94/176 (53%), Gaps = 4/176 (2%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
+EI Q + G++ SF ++ + D Q+K++ E+D +F + F
Sbjct: 330 DEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVD-VFKEKHMAPEFCSLE 388
Query: 405 E-MKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVY 463
E + YL+ + ETLR+YPP R+ Q+ + G++IPAG L +A LH P+ +
Sbjct: 389 EGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL--GQRIPAGAVLEMAVGALHHDPEHW 446
Query: 464 PNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFR 519
P+P F+P+ F E + ++PF AGPRSC+G + +L++K+ L +L FR
Sbjct: 447 PSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR 502
>AF233617-1|AAF99271.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 106 bits (254), Expect = 2e-22
Identities = 56/176 (31%), Positives = 94/176 (53%), Gaps = 4/176 (2%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
+EI Q + G++ SF ++ + D Q+K++ E+D +F + F
Sbjct: 330 DEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVD-VFKEKHMAPEFCSLE 388
Query: 405 E-MKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVY 463
E + YL+ + ETLR+YPP R+ Q+ + G++IPAG L +A LH P+ +
Sbjct: 389 EGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL--GQRIPAGAVLEMAVGALHHDPEHW 446
Query: 464 PNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFR 519
P+P F+P+ F E + ++PF AGPRSC+G + +L++K+ L +L FR
Sbjct: 447 PSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR 502
>AF233616-1|AAF99270.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 106 bits (254), Expect = 2e-22
Identities = 56/176 (31%), Positives = 94/176 (53%), Gaps = 4/176 (2%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
+EI Q + G++ SF ++ + D Q+K++ E+D +F + F
Sbjct: 330 DEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVD-VFKEKHMAPEFCSLE 388
Query: 405 E-MKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVY 463
E + YL+ + ETLR+YPP R+ Q+ + G++IPAG L +A LH P+ +
Sbjct: 389 EGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL--GQRIPAGAVLEMAVGALHHDPEHW 446
Query: 464 PNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFR 519
P+P F+P+ F E + ++PF AGPRSC+G + +L++K+ L +L FR
Sbjct: 447 PSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR 502
>AF233615-1|AAF99269.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 106 bits (254), Expect = 2e-22
Identities = 56/176 (31%), Positives = 94/176 (53%), Gaps = 4/176 (2%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
+EI Q + G++ SF ++ + D Q+K++ E+D +F + F
Sbjct: 330 DEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVD-VFKEKHMAPEFCSLE 388
Query: 405 E-MKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVY 463
E + YL+ + ETLR+YPP R+ Q+ + G++IPAG L +A LH P+ +
Sbjct: 389 EGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL--GQRIPAGAVLEMAVGALHHDPEHW 446
Query: 464 PNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFR 519
P+P F+P+ F E + ++PF AGPRSC+G + +L++K+ L +L FR
Sbjct: 447 PSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR 502
>AF233621-1|AAF99275.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 105 bits (253), Expect = 3e-22
Identities = 56/176 (31%), Positives = 94/176 (53%), Gaps = 4/176 (2%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
+EI Q + G++ SF ++ + D Q+K++ E+D +F + F
Sbjct: 330 DEIVGQAFIFLIAGYEIITNTLSFATYVLATNPDCQEKLLREVD-VFKEKHMAPEFCSLE 388
Query: 405 E-MKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVY 463
E + YL+ + ETLR+YPP R+ Q+ + G++IPAG L +A LH P+ +
Sbjct: 389 EGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL--GQRIPAGAVLEMAVGALHHDPEHW 446
Query: 464 PNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFR 519
P+P F+P+ F E + ++PF AGPRSC+G + +L++K+ L +L FR
Sbjct: 447 PSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR 502
>D34625-1|BAA07011.1| 533|Homo sapiens thromboxane synthase
protein.
Length = 533
Score = 105 bits (251), Expect = 5e-22
Identities = 56/176 (31%), Positives = 93/176 (52%), Gaps = 4/176 (2%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
+EI Q + G++ SF ++ + D Q+K++ E+D +F + F
Sbjct: 329 DEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVD-VFKEKHMAPEFCSLE 387
Query: 405 E-MKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVY 463
E + YL+ + ETLR+YPP R+ Q+ + G++IPAG L +A LH P+ +
Sbjct: 388 EGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL--GQRIPAGAVLEMAVGALHHDPEHW 445
Query: 464 PNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFR 519
P+P F+P+ F E + ++PF AGPRSC+G +L++K+ L +L FR
Sbjct: 446 PSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVHLGLLEVKLTLLHVLHKFR 501
>AF233622-1|AAF99276.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 105 bits (251), Expect = 5e-22
Identities = 55/176 (31%), Positives = 94/176 (53%), Gaps = 4/176 (2%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
+EI Q + G++ SF ++ + D Q+K++ E+D +F + F
Sbjct: 330 DEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVD-VFKEKHMAPEFCSLE 388
Query: 405 E-MKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVY 463
E + YL+ + ETLR+YPP R+ ++ + G++IPAG L +A LH P+ +
Sbjct: 389 EGLPYLDMVIAETLRMYPPAFRFTREAAEDCEVL--GQRIPAGAVLEMAVGALHHDPEHW 446
Query: 464 PNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFR 519
P+P F+P+ F E + ++PF AGPRSC+G + +L++K+ L +L FR
Sbjct: 447 PSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR 502
>AL358613-3|CAH72804.1| 428|Homo sapiens cytochrome P450, family
26, subfamily A, polypeptide 1 protein.
Length = 428
Score = 104 bits (249), Expect = 9e-22
Identities = 57/194 (29%), Positives = 104/194 (53%), Gaps = 7/194 (3%)
Query: 329 LDLLLESS-QSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEEL 387
L LL+E S + G + + +K+ ++F GH+TTA+ ++ ++ +G++ + KV EEL
Sbjct: 202 LQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREEL 261
Query: 388 DQ----IFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKI 443
+ D + + ++KY+ + ETLRL PPVP R + L NG +I
Sbjct: 262 KSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFEL--NGYQI 319
Query: 444 PAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYA 503
P G ++ + H +++ N +F+PD F+ + ++F+PF G RSCVG+++A
Sbjct: 320 PKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFA 379
Query: 504 MLKLKVILSTILRN 517
+ LK+ + R+
Sbjct: 380 KILLKIFTVELARH 393
>AL358613-2|CAH72803.1| 497|Homo sapiens cytochrome P450, family
26, subfamily A, polypeptide 1 protein.
Length = 497
Score = 104 bits (249), Expect = 9e-22
Identities = 57/194 (29%), Positives = 104/194 (53%), Gaps = 7/194 (3%)
Query: 329 LDLLLESS-QSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEEL 387
L LL+E S + G + + +K+ ++F GH+TTA+ ++ ++ +G++ + KV EEL
Sbjct: 271 LQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREEL 330
Query: 388 DQ----IFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKI 443
+ D + + ++KY+ + ETLRL PPVP R + L NG +I
Sbjct: 331 KSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFEL--NGYQI 388
Query: 444 PAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYA 503
P G ++ + H +++ N +F+PD F+ + ++F+PF G RSCVG+++A
Sbjct: 389 PKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFA 448
Query: 504 MLKLKVILSTILRN 517
+ LK+ + R+
Sbjct: 449 KILLKIFTVELARH 462
>AF005418-1|AAB88881.1| 497|Homo sapiens retinoic acid hydroxylase
protein.
Length = 497
Score = 104 bits (249), Expect = 9e-22
Identities = 57/194 (29%), Positives = 104/194 (53%), Gaps = 7/194 (3%)
Query: 329 LDLLLESS-QSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEEL 387
L LL+E S + G + + +K+ ++F GH+TTA+ ++ ++ +G++ + KV EEL
Sbjct: 271 LQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREEL 330
Query: 388 DQ----IFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKI 443
+ D + + ++KY+ + ETLRL PPVP R + L NG +I
Sbjct: 331 KSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFEL--NGYQI 388
Query: 444 PAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYA 503
P G ++ + H +++ N +F+PD F+ + ++F+PF G RSCVG+++A
Sbjct: 389 PKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFA 448
Query: 504 MLKLKVILSTILRN 517
+ LK+ + R+
Sbjct: 449 KILLKIFTVELARH 462
>D12621-1|BAA02145.1| 389|Homo sapiens cytochrome P-450LTBV
protein.
Length = 389
Score = 101 bits (243), Expect = 5e-21
Identities = 55/191 (28%), Positives = 100/191 (52%), Gaps = 8/191 (4%)
Query: 92 WIGP-RLLVFLYDPRDVEVILSSHVYIDKAEE--YRFFKPWLGNGLLISTGQKWRSHRKL 148
W+GP +V ++ P ++ +L + I ++ Y F KPWLG+GLL+S G+KW HR++
Sbjct: 91 WVGPWHAIVRIFHPTYIKPVLFAPAAIVPKDKVFYSFLKPWLGDGLLLSAGEKWSRHRRM 150
Query: 149 IAPTFHLNVLKSFIDLFNANSRAVVDK---LKKEAS-NFDCHDYMSECTVEILLETAMGV 204
+ P FH N+LK ++ +FN + + K L E S D +++S T++ L +
Sbjct: 151 LTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSARLDMFEHISLMTLDSLQKCVFSF 210
Query: 205 SKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTKK 264
Q++ EY A++++ ++ RH +I L D L+ T + + ++H T
Sbjct: 211 DSHCQEKPS-EYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFRRACRLVHDFTDA 269
Query: 265 VIKRKKEEFAS 275
VI+ ++ S
Sbjct: 270 VIQERRRTLPS 280
Score = 75.4 bits (177), Expect = 5e-13
Identities = 35/98 (35%), Positives = 61/98 (62%), Gaps = 2/98 (2%)
Query: 322 QKKRLAFLD-LLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
+ K L F+D LLL + G +SDE+I+ + DT MFEGHDTTA+G S+ L + H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351
Query: 381 DKVIEELDQIFGDSD-RPVTFQDTLEMKYLERCLMETL 417
++ +E+ ++ D + + + + D ++ +L C+ E+L
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESL 389
>BC032322-1|AAH32322.1| 509|Homo sapiens cytochrome P450, family
51, subfamily A, polypeptide 1 protein.
Length = 509
Score = 101 bits (241), Expect = 9e-21
Identities = 57/196 (29%), Positives = 103/196 (52%), Gaps = 3/196 (1%)
Query: 322 QKKRLAFLDLLLESS-QSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
Q+K L LL+++ + G ++D+E+ + ++ G T++ S++ + + +Q
Sbjct: 281 QEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQ 340
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
K E + G++ P+T+ ++ L+RC+ ETLRL PPV I+ R T+ G
Sbjct: 341 KKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPVMIMMRMARTPQTVA--G 398
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
IP G + ++ R D + F+PD +L + A+ +A+VPF AG C+G
Sbjct: 399 YTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGE 458
Query: 501 KYAMLKLKVILSTILR 516
+A +++K I ST+LR
Sbjct: 459 NFAYVQIKTIWSTMLR 474
>U51692-1|AAC50951.1| 503|Homo sapiens lanosterol 14-alpha
demethylase protein.
Length = 503
Score = 100 bits (240), Expect = 1e-20
Identities = 56/196 (28%), Positives = 103/196 (52%), Gaps = 3/196 (1%)
Query: 322 QKKRLAFLDLLLESS-QSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
Q+K L LL+++ + G ++D+E+ + ++ G T++ S++ + + +Q
Sbjct: 275 QEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQ 334
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
K E + G++ P+T+ ++ L+RC+ ETLRL PP+ I+ R T+ G
Sbjct: 335 KKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIRETLRLRPPIMIMMRMARTPQTVA--G 392
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
IP G + ++ R D + F+PD +L + A+ +A+VPF AG C+G
Sbjct: 393 YTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGE 452
Query: 501 KYAMLKLKVILSTILR 516
+A +++K I ST+LR
Sbjct: 453 NFAYVQIKTIWSTMLR 468
>U23942-1|AAB39951.1| 509|Homo sapiens lanosterol 14-demethylase
cytochrome P450 protein.
Length = 509
Score = 100 bits (240), Expect = 1e-20
Identities = 56/196 (28%), Positives = 103/196 (52%), Gaps = 3/196 (1%)
Query: 322 QKKRLAFLDLLLESS-QSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
Q+K L LL+++ + G ++D+E+ + ++ G T++ S++ + + +Q
Sbjct: 281 QEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQ 340
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
K E + G++ P+T+ ++ L+RC+ ETLRL PP+ I+ R T+ G
Sbjct: 341 KKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVA--G 398
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
IP G + ++ R D + F+PD +L + A+ +A+VPF AG C+G
Sbjct: 399 YTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGE 458
Query: 501 KYAMLKLKVILSTILR 516
+A +++K I ST+LR
Sbjct: 459 NFAYVQIKTIWSTMLR 474
>D55653-1|BAA09512.1| 509|Homo sapiens lanosterol 14-demethylase
protein.
Length = 509
Score = 100 bits (240), Expect = 1e-20
Identities = 56/196 (28%), Positives = 103/196 (52%), Gaps = 3/196 (1%)
Query: 322 QKKRLAFLDLLLESS-QSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
Q+K L LL+++ + G ++D+E+ + ++ G T++ S++ + + +Q
Sbjct: 281 QEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQ 340
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
K E + G++ P+T+ ++ L+RC+ ETLRL PP+ I+ R T+ G
Sbjct: 341 KKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVA--G 398
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
IP G + ++ R D + F+PD +L + A+ +A+VPF AG C+G
Sbjct: 399 YTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGE 458
Query: 501 KYAMLKLKVILSTILR 516
+A +++K I ST+LR
Sbjct: 459 NFAYVQIKTIWSTMLR 474
>AC000120-2|AAB46356.1| 509|Homo sapiens unknown protein.
Length = 509
Score = 100 bits (240), Expect = 1e-20
Identities = 56/196 (28%), Positives = 103/196 (52%), Gaps = 3/196 (1%)
Query: 322 QKKRLAFLDLLLESS-QSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
Q+K L LL+++ + G ++D+E+ + ++ G T++ S++ + + +Q
Sbjct: 281 QEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQ 340
Query: 381 DKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNG 440
K E + G++ P+T+ ++ L+RC+ ETLRL PP+ I+ R T+ G
Sbjct: 341 KKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVA--G 398
Query: 441 KKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGR 500
IP G + ++ R D + F+PD +L + A+ +A+VPF AG C+G
Sbjct: 399 YTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGE 458
Query: 501 KYAMLKLKVILSTILR 516
+A +++K I ST+LR
Sbjct: 459 NFAYVQIKTIWSTMLR 474
>Y07508-1|CAA68807.1| 503|Homo sapiens protein ( Human mRNA for
aromatase P-450. ).
Length = 503
Score = 96.7 bits (230), Expect = 2e-19
Identities = 49/179 (27%), Positives = 97/179 (54%), Gaps = 9/179 (5%)
Query: 342 ISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQ 401
++ E + + + ++ DT + F L ++ H ++++ +I+E+ + G+ D +
Sbjct: 291 LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD--IKID 348
Query: 402 DTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPD 461
D ++K +E + E++R P V ++ R+ ++ + +G + GT +++ ++HR +
Sbjct: 349 DIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI--DGYPVKKGTNIILNIGRMHRL-E 405
Query: 462 VYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV 520
+P PN+F +NF + N Y F PF GPR C G+ AM+ +K IL T+LR F V
Sbjct: 406 FFPKPNEFTLENF----AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>X13589-1|CAA31929.1| 503|Homo sapiens protein ( Human mRNA for
aromatase (estrogen synthetase). ).
Length = 503
Score = 96.7 bits (230), Expect = 2e-19
Identities = 49/179 (27%), Positives = 97/179 (54%), Gaps = 9/179 (5%)
Query: 342 ISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQ 401
++ E + + + ++ DT + F L ++ H ++++ +I+E+ + G+ D +
Sbjct: 291 LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD--IKID 348
Query: 402 DTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPD 461
D ++K +E + E++R P V ++ R+ ++ + +G + GT +++ ++HR +
Sbjct: 349 DIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI--DGYPVKKGTNIILNIGRMHRL-E 405
Query: 462 VYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV 520
+P PN+F +NF + N Y F PF GPR C G+ AM+ +K IL T+LR F V
Sbjct: 406 FFPKPNEFTLENF----AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>M30804-1|AAA35728.1| 503|Homo sapiens protein ( Human aromatase
cytochrome P-450 gene, exon 10. ).
Length = 503
Score = 96.7 bits (230), Expect = 2e-19
Identities = 49/179 (27%), Positives = 97/179 (54%), Gaps = 9/179 (5%)
Query: 342 ISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQ 401
++ E + + + ++ DT + F L ++ H ++++ +I+E+ + G+ D +
Sbjct: 291 LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD--IKID 348
Query: 402 DTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPD 461
D ++K +E + E++R P V ++ R+ ++ + +G + GT +++ ++HR +
Sbjct: 349 DIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI--DGYPVKKGTNIILNIGRMHRL-E 405
Query: 462 VYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV 520
+P PN+F +NF + N Y F PF GPR C G+ AM+ +K IL T+LR F V
Sbjct: 406 FFPKPNEFTLENF----AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>M28420-1|AAA52141.1| 419|Homo sapiens cytochrome P-450 aromatase
protein.
Length = 419
Score = 96.7 bits (230), Expect = 2e-19
Identities = 49/179 (27%), Positives = 97/179 (54%), Gaps = 9/179 (5%)
Query: 342 ISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQ 401
++ E + + + ++ DT + F L ++ H ++++ +I+E+ + G+ D +
Sbjct: 207 LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD--IKID 264
Query: 402 DTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPD 461
D ++K +E + E++R P V ++ R+ ++ + +G + GT +++ ++HR +
Sbjct: 265 DIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI--DGYPVKKGTNIILNIGRMHRL-E 321
Query: 462 VYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV 520
+P PN+F +NF + N Y F PF GPR C G+ AM+ +K IL T+LR F V
Sbjct: 322 FFPKPNEFTLENF----AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 376
>M22246-1|AAA35557.1| 503|Homo sapiens protein ( Human aromatase
mRNA, complete cds. ).
Length = 503
Score = 96.7 bits (230), Expect = 2e-19
Identities = 49/179 (27%), Positives = 97/179 (54%), Gaps = 9/179 (5%)
Query: 342 ISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQ 401
++ E + + + ++ DT + F L ++ H ++++ +I+E+ + G+ D +
Sbjct: 291 LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD--IKID 348
Query: 402 DTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPD 461
D ++K +E + E++R P V ++ R+ ++ + +G + GT +++ ++HR +
Sbjct: 349 DIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI--DGYPVKKGTNIILNIGRMHRL-E 405
Query: 462 VYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV 520
+P PN+F +NF + N Y F PF GPR C G+ AM+ +K IL T+LR F V
Sbjct: 406 FFPKPNEFTLENF----AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>M18856-1|AAA35556.1| 419|Homo sapiens protein ( Human aromatase
(Aro1) mRNA, complete cds. ).
Length = 419
Score = 96.7 bits (230), Expect = 2e-19
Identities = 49/179 (27%), Positives = 97/179 (54%), Gaps = 9/179 (5%)
Query: 342 ISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQ 401
++ E + + + ++ DT + F L ++ H ++++ +I+E+ + G+ D +
Sbjct: 207 LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD--IKID 264
Query: 402 DTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPD 461
D ++K +E + E++R P V ++ R+ ++ + +G + GT +++ ++HR +
Sbjct: 265 DIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI--DGYPVKKGTNIILNIGRMHRL-E 321
Query: 462 VYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV 520
+P PN+F +NF + N Y F PF GPR C G+ AM+ +K IL T+LR F V
Sbjct: 322 FFPKPNEFTLENF----AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 376
>J04127-1|AAA52132.1| 503|Homo sapiens CYP19 protein.
Length = 503
Score = 96.7 bits (230), Expect = 2e-19
Identities = 49/179 (27%), Positives = 97/179 (54%), Gaps = 9/179 (5%)
Query: 342 ISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQ 401
++ E + + + ++ DT + F L ++ H ++++ +I+E+ + G+ D +
Sbjct: 291 LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD--IKID 348
Query: 402 DTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPD 461
D ++K +E + E++R P V ++ R+ ++ + +G + GT +++ ++HR +
Sbjct: 349 DIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI--DGYPVKKGTNIILNIGRMHRL-E 405
Query: 462 VYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV 520
+P PN+F +NF + N Y F PF GPR C G+ AM+ +K IL T+LR F V
Sbjct: 406 FFPKPNEFTLENF----AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>DQ118405-1|AAZ23558.1| 503|Homo sapiens cytochrome P450 subfamily
19 subfamily A polypeptide 1 protein.
Length = 503
Score = 96.7 bits (230), Expect = 2e-19
Identities = 49/179 (27%), Positives = 97/179 (54%), Gaps = 9/179 (5%)
Query: 342 ISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQ 401
++ E + + + ++ DT + F L ++ H ++++ +I+E+ + G+ D +
Sbjct: 291 LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD--IKID 348
Query: 402 DTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPD 461
D ++K +E + E++R P V ++ R+ ++ + +G + GT +++ ++HR +
Sbjct: 349 DIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI--DGYPVKKGTNIILNIGRMHRL-E 405
Query: 462 VYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV 520
+P PN+F +NF + N Y F PF GPR C G+ AM+ +K IL T+LR F V
Sbjct: 406 FFPKPNEFTLENF----AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>BC107785-1|AAI07786.1| 503|Homo sapiens cytochrome P450, family
19, subfamily A, polypeptide 1 protein.
Length = 503
Score = 96.7 bits (230), Expect = 2e-19
Identities = 49/179 (27%), Positives = 97/179 (54%), Gaps = 9/179 (5%)
Query: 342 ISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQ 401
++ E + + + ++ DT + F L ++ H ++++ +I+E+ + G+ D +
Sbjct: 291 LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD--IKID 348
Query: 402 DTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPD 461
D ++K +E + E++R P V ++ R+ ++ + +G + GT +++ ++HR +
Sbjct: 349 DIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI--DGYPVKKGTNIILNIGRMHRL-E 405
Query: 462 VYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV 520
+P PN+F +NF + N Y F PF GPR C G+ AM+ +K IL T+LR F V
Sbjct: 406 FFPKPNEFTLENF----AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>BC035959-1|AAH35959.1| 503|Homo sapiens cytochrome P450, family
19, subfamily A, polypeptide 1 protein.
Length = 503
Score = 96.7 bits (230), Expect = 2e-19
Identities = 49/179 (27%), Positives = 97/179 (54%), Gaps = 9/179 (5%)
Query: 342 ISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQ 401
++ E + + + ++ DT + F L ++ H ++++ +I+E+ + G+ D +
Sbjct: 291 LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD--IKID 348
Query: 402 DTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPD 461
D ++K +E + E++R P V ++ R+ ++ + +G + GT +++ ++HR +
Sbjct: 349 DIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI--DGYPVKKGTNIILNIGRMHRL-E 405
Query: 462 VYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV 520
+P PN+F +NF + N Y F PF GPR C G+ AM+ +K IL T+LR F V
Sbjct: 406 FFPKPNEFTLENF----AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>AY957953-1|AAX44046.1| 503|Homo sapiens cytochrome P450, family
19, subfamily A, polypeptide 1 protein.
Length = 503
Score = 96.7 bits (230), Expect = 2e-19
Identities = 49/179 (27%), Positives = 97/179 (54%), Gaps = 9/179 (5%)
Query: 342 ISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQ 401
++ E + + + ++ DT + F L ++ H ++++ +I+E+ + G+ D +
Sbjct: 291 LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD--IKID 348
Query: 402 DTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPD 461
D ++K +E + E++R P V ++ R+ ++ + +G + GT +++ ++HR +
Sbjct: 349 DIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI--DGYPVKKGTNIILNIGRMHRL-E 405
Query: 462 VYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV 520
+P PN+F +NF + N Y F PF GPR C G+ AM+ +K IL T+LR F V
Sbjct: 406 FFPKPNEFTLENF----AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>BC132767-1|AAI32768.1| 544|Homo sapiens cytochrome P450, family 2,
subfamily U, polypeptide 1 protein.
Length = 544
Score = 95.5 bits (227), Expect = 4e-19
Identities = 51/183 (27%), Positives = 95/183 (51%), Gaps = 2/183 (1%)
Query: 336 SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSD 395
+ S + +E + + + G DTT + L M ++ D+Q+KV EE++++ G ++
Sbjct: 331 NNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIG-AN 389
Query: 396 RPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYK 455
R + D +M Y E +ME RL VP+ + E T+ G IP GT ++ +
Sbjct: 390 RAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTV-LQGYTIPKGTLILPNLWS 448
Query: 456 LHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTIL 515
+HR P ++ P F P+ FL ++ F+PF G R C+G + A ++L ++ +++
Sbjct: 449 VHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLM 508
Query: 516 RNF 518
++F
Sbjct: 509 QSF 511
>AY343323-1|AAQ21380.1| 544|Homo sapiens cytochrome P450 protein.
Length = 544
Score = 95.5 bits (227), Expect = 4e-19
Identities = 51/183 (27%), Positives = 95/183 (51%), Gaps = 2/183 (1%)
Query: 336 SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSD 395
+ S + +E + + + G DTT + L M ++ D+Q+KV EE++++ G ++
Sbjct: 331 NNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIG-AN 389
Query: 396 RPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYK 455
R + D +M Y E +ME RL VP+ + E T+ G IP GT ++ +
Sbjct: 390 RAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTV-LQGYTIPKGTLILPNLWS 448
Query: 456 LHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTIL 515
+HR P ++ P F P+ FL ++ F+PF G R C+G + A ++L ++ +++
Sbjct: 449 VHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLM 508
Query: 516 RNF 518
++F
Sbjct: 509 QSF 511
>AJ563378-3|CAD91347.1| 173|Homo sapiens hypothetical protein
protein.
Length = 173
Score = 95.1 bits (226), Expect = 6e-19
Identities = 46/138 (33%), Positives = 79/138 (57%), Gaps = 4/138 (2%)
Query: 397 PVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKL 456
P T+ ++M+YL+ + ETLRL+P + R +++ + NG IP G+ +VI TY L
Sbjct: 15 PPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI--NGVFIPKGSMVVIPTYAL 72
Query: 457 HRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILR 516
H P + P +F P+ F ++ + Y + PF GPR+C+G ++A++ +K+ L +L+
Sbjct: 73 HHDPKYWTEPEEFRPERFSKKKDSIDPYI-YTPFGTGPRNCIGMRFALMNMKLALIRVLQ 131
Query: 517 NFRVISDLKESDFKLQAD 534
NF KE+ L+ D
Sbjct: 132 NFS-FKPCKETQIPLKLD 148
>AJ563378-2|CAD91647.1| 160|Homo sapiens cytochrome P450 protein.
Length = 160
Score = 95.1 bits (226), Expect = 6e-19
Identities = 46/138 (33%), Positives = 79/138 (57%), Gaps = 4/138 (2%)
Query: 397 PVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKL 456
P T+ ++M+YL+ + ETLRL+P + R +++ + NG IP G+ +VI TY L
Sbjct: 2 PPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI--NGVFIPKGSMVVIPTYAL 59
Query: 457 HRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILR 516
H P + P +F P+ F ++ + Y + PF GPR+C+G ++A++ +K+ L +L+
Sbjct: 60 HHDPKYWTEPEEFRPERFSKKKDSIDPYI-YTPFGTGPRNCIGMRFALMNMKLALIRVLQ 118
Query: 517 NFRVISDLKESDFKLQAD 534
NF KE+ L+ D
Sbjct: 119 NFS-FKPCKETQIPLKLD 135
>AF280110-1|AAG33011.1| 420|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 420
Score = 93.9 bits (223), Expect = 1e-18
Identities = 52/156 (33%), Positives = 86/156 (55%), Gaps = 8/156 (5%)
Query: 322 QKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIH 376
QK R+ F +++S ++S A+SD E+ Q I+F +DTT+ F + + H
Sbjct: 265 QKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATH 324
Query: 377 QDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITL 436
D+Q K+ EE+D + + PVT+ ++M+YL+ + ETLRL+P V + R ++I +
Sbjct: 325 PDVQQKLQEEIDAVL-PNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI 383
Query: 437 PSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPD 472
NG IP G +++ Y LH P + P KF P+
Sbjct: 384 --NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPE 417
Score = 35.9 bits (79), Expect = 0.37
Identities = 23/119 (19%), Positives = 54/119 (45%), Gaps = 4/119 (3%)
Query: 91 IWIGPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKP-WLGNGLLISTGQKWRSHRKLI 149
++ G + ++ + DP ++ +L Y + +L + L + ++W+ R L+
Sbjct: 74 LYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLL 133
Query: 150 APTFHLNVLKSFIDLFNANSRAVVDKLKKEASN---FDCHDYMSECTVEILLETAMGVS 205
+P F K + + + +V L++EA N + D+ T++++ T GV+
Sbjct: 134 SPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVN 192
>X59812-1|CAA42481.1| 530|Homo sapiens Vitamin D3 25-hydroxylase
protein.
Length = 530
Score = 93.1 bits (221), Expect = 2e-18
Identities = 62/214 (28%), Positives = 106/214 (49%), Gaps = 11/214 (5%)
Query: 328 FLDLLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEEL 387
+L LL S Q +S E + ++ G DTT+ ++ L + +IQ+ + EE+
Sbjct: 309 YLHFLLASGQ----LSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEV 364
Query: 388 DQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGT 447
+ P +D M L+ L ETLRLYP VP +R + +EI + +G P T
Sbjct: 365 VGVVPAGQVP-QHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEV--DGFLFPKNT 421
Query: 448 TLVIATYKLHRRPDVYPNPNKFDPDNFL----PERSANRHYYAFVPFSAGPRSCVGRKYA 503
V Y + R P + P F P +L P +H + VPF G R+C+GR+ A
Sbjct: 422 QFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIA 481
Query: 504 MLKLKVILSTILRNFRVISDLKESDFKLQADIIL 537
L+++++L+ +++ ++V+ + + K A I+L
Sbjct: 482 ELEMQLLLARLIQKYKVVLAPETGELKSVARIVL 515
>M62401-1|AAA52142.1| 531|Homo sapiens sterol 27-hydroxylase
protein.
Length = 531
Score = 93.1 bits (221), Expect = 2e-18
Identities = 62/214 (28%), Positives = 106/214 (49%), Gaps = 11/214 (5%)
Query: 328 FLDLLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEEL 387
+L LL S Q +S E + ++ G DTT+ ++ L + +IQ+ + EE+
Sbjct: 310 YLHFLLASGQ----LSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEV 365
Query: 388 DQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGT 447
+ P +D M L+ L ETLRLYP VP +R + +EI + +G P T
Sbjct: 366 VGVVPAGQVP-QHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEV--DGFLFPKNT 422
Query: 448 TLVIATYKLHRRPDVYPNPNKFDPDNFL----PERSANRHYYAFVPFSAGPRSCVGRKYA 503
V Y + R P + P F P +L P +H + VPF G R+C+GR+ A
Sbjct: 423 QFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIA 482
Query: 504 MLKLKVILSTILRNFRVISDLKESDFKLQADIIL 537
L+++++L+ +++ ++V+ + + K A I+L
Sbjct: 483 ELEMQLLLARLIQKYKVVLAPETGELKSVARIVL 516
>BC051851-1|AAH51851.1| 531|Homo sapiens cytochrome P450, family
27, subfamily A, polypeptide 1 protein.
Length = 531
Score = 93.1 bits (221), Expect = 2e-18
Identities = 62/214 (28%), Positives = 106/214 (49%), Gaps = 11/214 (5%)
Query: 328 FLDLLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEEL 387
+L LL S Q +S E + ++ G DTT+ ++ L + +IQ+ + EE+
Sbjct: 310 YLHFLLASGQ----LSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEV 365
Query: 388 DQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGT 447
+ P +D M L+ L ETLRLYP VP +R + +EI + +G P T
Sbjct: 366 VGVVPAGQVP-QHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEV--DGFLFPKNT 422
Query: 448 TLVIATYKLHRRPDVYPNPNKFDPDNFL----PERSANRHYYAFVPFSAGPRSCVGRKYA 503
V Y + R P + P F P +L P +H + VPF G R+C+GR+ A
Sbjct: 423 QFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIA 482
Query: 504 MLKLKVILSTILRNFRVISDLKESDFKLQADIIL 537
L+++++L+ +++ ++V+ + + K A I+L
Sbjct: 483 ELEMQLLLARLIQKYKVVLAPETGELKSVARIVL 516
>BC040430-1|AAH40430.1| 531|Homo sapiens cytochrome P450, family
27, subfamily A, polypeptide 1 protein.
Length = 531
Score = 93.1 bits (221), Expect = 2e-18
Identities = 62/214 (28%), Positives = 106/214 (49%), Gaps = 11/214 (5%)
Query: 328 FLDLLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEEL 387
+L LL S Q +S E + ++ G DTT+ ++ L + +IQ+ + EE+
Sbjct: 310 YLHFLLASGQ----LSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEV 365
Query: 388 DQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGT 447
+ P +D M L+ L ETLRLYP VP +R + +EI + +G P T
Sbjct: 366 VGVVPAGQVP-QHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEV--DGFLFPKNT 422
Query: 448 TLVIATYKLHRRPDVYPNPNKFDPDNFL----PERSANRHYYAFVPFSAGPRSCVGRKYA 503
V Y + R P + P F P +L P +H + VPF G R+C+GR+ A
Sbjct: 423 QFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIA 482
Query: 504 MLKLKVILSTILRNFRVISDLKESDFKLQADIIL 537
L+++++L+ +++ ++V+ + + K A I+L
Sbjct: 483 ELEMQLLLARLIQKYKVVLAPETGELKSVARIVL 516
>AY178622-1|AAO21126.1| 531|Homo sapiens steroid hydroxylase
protein.
Length = 531
Score = 93.1 bits (221), Expect = 2e-18
Identities = 62/214 (28%), Positives = 106/214 (49%), Gaps = 11/214 (5%)
Query: 328 FLDLLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEEL 387
+L LL S Q +S E + ++ G DTT+ ++ L + +IQ + EE+
Sbjct: 310 YLHFLLASGQ----LSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQKALHEEV 365
Query: 388 DQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGT 447
+ P +D M L+ L ETLRLYP VP +R + +EI + +G P T
Sbjct: 366 VGVVPAGQVP-QHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEV--DGFLFPKNT 422
Query: 448 TLVIATYKLHRRPDVYPNPNKFDPDNFL----PERSANRHYYAFVPFSAGPRSCVGRKYA 503
V Y++ R P + P F P +L P +H + VPF G R+C+GR+ A
Sbjct: 423 QFVFCHYEVSRDPTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIA 482
Query: 504 MLKLKVILSTILRNFRVISDLKESDFKLQADIIL 537
L+++++L+ +++ ++V+ + + K A I+L
Sbjct: 483 ELEMQLLLARLIQKYKVVLAPETGELKSVARIVL 516
>AK097373-1|BAC05026.1| 340|Homo sapiens protein ( Homo sapiens
cDNA FLJ40054 fis, clone TBAES2000315, weakly similar to
CYTOCHROME P450 4A1 (EC 1.14.15.3). ).
Length = 340
Score = 92.7 bits (220), Expect = 3e-18
Identities = 52/188 (27%), Positives = 101/188 (53%), Gaps = 6/188 (3%)
Query: 89 VKIWIGPRLLVF-LYDPRDVEVILSSHVYIDKAEEYRFFKPWLGNGLLISTGQKWRSHRK 147
V +W+GP + F ++DP V+++L A ++ + W+G GL+ G KW+ HR+
Sbjct: 80 VPLWVGPFTMFFNIHDPDYVKILLKRQDP-KSAVSHKILESWVGRGLVTLDGSKWKKHRQ 138
Query: 148 LIAPTFHLNVLKSFIDLFNANSRAVVDKLKK---EASNFDCHDYMSECTVEILLETAMGV 204
++ P F++++LK FI + + + R +++K ++ + S + ++S T++ +++ A
Sbjct: 139 IVKPGFNISILKIFITMMSKSVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSH 198
Query: 205 SKSTQ-DQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTK 263
S Q D + Y AV + I + R DL+FKF+ + +K +H T+
Sbjct: 199 QGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFTE 258
Query: 264 KVIKRKKE 271
KVI+ +KE
Sbjct: 259 KVIQDRKE 266
Score = 42.3 bits (95), Expect = 0.004
Identities = 21/62 (33%), Positives = 36/62 (58%), Gaps = 1/62 (1%)
Query: 322 QKKRLAFLDLLLES-SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQ 380
QK+R FLD+LL + S++ S+ +++ +V T MF GHDTT S+ + + + Q
Sbjct: 278 QKRRQDFLDILLSAKSENTKDFSEADLQAEVKTFMFAGHDTTTTAISWIFYCLAKYPEHQ 337
Query: 381 DK 382
+
Sbjct: 338 QR 339
>BC100982-1|AAI00983.1| 280|Homo sapiens CYP3A43 protein protein.
Length = 280
Score = 91.9 bits (218), Expect = 5e-18
Identities = 51/157 (32%), Positives = 86/157 (54%), Gaps = 8/157 (5%)
Query: 321 GQKKRLAFLDLLLES-----SQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGI 375
G + R+ F +++S ++S A+SD E+ Q I+F +DTT+ F + +
Sbjct: 124 GLQHRVDFFQQIIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELAT 183
Query: 376 HQDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPIIARQVNQEIT 435
H D+Q K+ EE+D + + PVT+ ++M+YL+ + ETLRL+P V + R ++I
Sbjct: 184 HPDVQQKLQEEIDAVL-PNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIE 242
Query: 436 LPSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPD 472
+ NG IP G +++ Y LH P + P KF P+
Sbjct: 243 I--NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPE 277
>AY696295-1|AAU10524.1| 292|Homo sapiens cytochrome P450 protein.
Length = 292
Score = 91.9 bits (218), Expect = 5e-18
Identities = 52/188 (27%), Positives = 99/188 (52%), Gaps = 6/188 (3%)
Query: 89 VKIWIGPRLLVF-LYDPRDVEVILSSHVYIDKAEEYRFFKPWLGNGLLISTGQKWRSHRK 147
V +W+GP + F ++DP V+++L A ++ + W+G GL+ G KW+ HR+
Sbjct: 80 VPLWVGPFTMFFNIHDPDYVKILLKRQ-NPKSAVSHKILESWVGRGLVTLDGSKWKKHRQ 138
Query: 148 LIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEA---SNFDCHDYMSECTVEILLETAMGV 204
++ P F++++LK FI + + + R +++K ++ S + ++S T+ +++ A
Sbjct: 139 IVKPGFNISILKIFITMMSKSVRMMLNKWEEHIAHNSRLELFQHVSLMTLHSIMKCAFSH 198
Query: 205 SKSTQ-DQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTK 263
S Q D + Y AV + I + R DL+FKF+ + +K +H T+
Sbjct: 199 QGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFTE 258
Query: 264 KVIKRKKE 271
KVI+ +KE
Sbjct: 259 KVIQDRKE 266
>X13930-1|CAA32118.1| 494|Homo sapiens protein ( Human CYP2A4 mRNA
for P-450 IIA4 protein. ).
Length = 494
Score = 91.5 bits (217), Expect = 7e-18
Identities = 51/172 (29%), Positives = 91/172 (52%), Gaps = 4/172 (2%)
Query: 358 GHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETL 417
G +T + + ++ H +++ KV EE+D++ G + +P F+D +M Y+E + E
Sbjct: 302 GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRAKMPYMEAVIHEIQ 360
Query: 418 RLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLP 476
R +P+ +AR+V ++ +P GT + + R P + NP F+P +FL
Sbjct: 361 RFGDVIPMSLARRVKKDTKF--RDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLN 418
Query: 477 ERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVISDLKESD 528
E+ + AFVPFS G R+C G A ++L + +T+++NFR+ S D
Sbjct: 419 EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKD 470
>X13929-1|CAA32117.1| 448|Homo sapiens P-450 IIA3 protein (1 is 3rd
base in codon) protein.
Length = 448
Score = 91.5 bits (217), Expect = 7e-18
Identities = 51/172 (29%), Positives = 91/172 (52%), Gaps = 4/172 (2%)
Query: 358 GHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETL 417
G +T + + ++ H +++ KV EE+D++ G + +P F+D +M Y+E + E
Sbjct: 256 GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRAKMPYMEAVIHEIQ 314
Query: 418 RLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLP 476
R +P+ +AR+V ++ +P GT + + R P + NP F+P +FL
Sbjct: 315 RFGDVIPMSLARRVKKDTKF--RDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLN 372
Query: 477 ERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVISDLKESD 528
E+ + AFVPFS G R+C G A ++L + +T+++NFR+ S D
Sbjct: 373 EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKD 424
>M33318-1|AAA52067.1| 494|Homo sapiens CYP2A protein.
Length = 494
Score = 91.5 bits (217), Expect = 7e-18
Identities = 51/172 (29%), Positives = 91/172 (52%), Gaps = 4/172 (2%)
Query: 358 GHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETL 417
G +T + + ++ H +++ KV EE+D++ G + +P F+D +M Y+E + E
Sbjct: 302 GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRAKMPYMEAVIHEIQ 360
Query: 418 RLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLP 476
R +P+ +AR+V ++ +P GT + + R P + NP F+P +FL
Sbjct: 361 RFGDVIPMSLARRVKKDTKF--RDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLN 418
Query: 477 ERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVISDLKESD 528
E+ + AFVPFS G R+C G A ++L + +T+++NFR+ S D
Sbjct: 419 EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKD 470
>L13286-1|AAA62379.1| 513|Homo sapiens 1,25-dihydroxyvitamin D3
24-hydroxylase protein.
Length = 513
Score = 91.5 bits (217), Expect = 7e-18
Identities = 51/179 (28%), Positives = 94/179 (52%), Gaps = 4/179 (2%)
Query: 342 ISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQ 401
+S +E+ V + +TTA + L + + +Q K+++E+ + ++ RP +
Sbjct: 310 LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQRPRE-E 368
Query: 402 DTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPD 461
D M YL+ CL E++RL P VP R +++ L +P GT L++ T L D
Sbjct: 369 DLRNMPYLKACLKESMRLTPGVPFTTRTLDKATVLGEYA--LPKGTVLMLNTQVLGSSED 426
Query: 462 VYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV 520
+ + ++F P+ +L E+ + +A +PF G R C+GR+ A L+L + L I+R + +
Sbjct: 427 NFEDSSQFRPERWLQEKE-KINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDI 484
>BC096256-1|AAH96256.1| 494|Homo sapiens cytochrome P450, family 2,
subfamily A, polypeptide 6 protein.
Length = 494
Score = 91.5 bits (217), Expect = 7e-18
Identities = 51/172 (29%), Positives = 91/172 (52%), Gaps = 4/172 (2%)
Query: 358 GHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETL 417
G +T + + ++ H +++ KV EE+D++ G + +P F+D +M Y+E + E
Sbjct: 302 GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRAKMPYMEAVIHEIQ 360
Query: 418 RLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLP 476
R +P+ +AR+V ++ +P GT + + R P + NP F+P +FL
Sbjct: 361 RFGDVIPMSLARRVKKDTKF--RDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLN 418
Query: 477 ERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVISDLKESD 528
E+ + AFVPFS G R+C G A ++L + +T+++NFR+ S D
Sbjct: 419 EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKD 470
>BC096255-1|AAH96255.1| 494|Homo sapiens cytochrome P450, family 2,
subfamily A, polypeptide 6 protein.
Length = 494
Score = 91.5 bits (217), Expect = 7e-18
Identities = 51/172 (29%), Positives = 91/172 (52%), Gaps = 4/172 (2%)
Query: 358 GHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETL 417
G +T + + ++ H +++ KV EE+D++ G + +P F+D +M Y+E + E
Sbjct: 302 GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRAKMPYMEAVIHEIQ 360
Query: 418 RLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLP 476
R +P+ +AR+V ++ +P GT + + R P + NP F+P +FL
Sbjct: 361 RFGDVIPMSLARRVKKDTKF--RDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLN 418
Query: 477 ERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVISDLKESD 528
E+ + AFVPFS G R+C G A ++L + +T+++NFR+ S D
Sbjct: 419 EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKD 470
>BC096254-1|AAH96254.1| 494|Homo sapiens cytochrome P450, family 2,
subfamily A, polypeptide 6 protein.
Length = 494
Score = 91.5 bits (217), Expect = 7e-18
Identities = 51/172 (29%), Positives = 91/172 (52%), Gaps = 4/172 (2%)
Query: 358 GHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETL 417
G +T + + ++ H +++ KV EE+D++ G + +P F+D +M Y+E + E
Sbjct: 302 GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRAKMPYMEAVIHEIQ 360
Query: 418 RLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLP 476
R +P+ +AR+V ++ +P GT + + R P + NP F+P +FL
Sbjct: 361 RFGDVIPMSLARRVKKDTKF--RDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLN 418
Query: 477 ERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVISDLKESD 528
E+ + AFVPFS G R+C G A ++L + +T+++NFR+ S D
Sbjct: 419 EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKD 470
>BC096253-1|AAH96253.3| 494|Homo sapiens cytochrome P450, family 2,
subfamily A, polypeptide 6 protein.
Length = 494
Score = 91.5 bits (217), Expect = 7e-18
Identities = 51/172 (29%), Positives = 91/172 (52%), Gaps = 4/172 (2%)
Query: 358 GHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETL 417
G +T + + ++ H +++ KV EE+D++ G + +P F+D +M Y+E + E
Sbjct: 302 GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRAKMPYMEAVIHEIQ 360
Query: 418 RLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLP 476
R +P+ +AR+V ++ +P GT + + R P + NP F+P +FL
Sbjct: 361 RFGDVIPMSLARRVKKDTKF--RDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLN 418
Query: 477 ERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVISDLKESD 528
E+ + AFVPFS G R+C G A ++L + +T+++NFR+ S D
Sbjct: 419 EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKD 470
>AF182275-1|AAF13600.1| 494|Homo sapiens cytochrome P450-2A6
protein.
Length = 494
Score = 91.5 bits (217), Expect = 7e-18
Identities = 51/172 (29%), Positives = 91/172 (52%), Gaps = 4/172 (2%)
Query: 358 GHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETL 417
G +T + + ++ H +++ KV EE+D++ G + +P F+D +M Y+E + E
Sbjct: 302 GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRAKMPYMEAVIHEIQ 360
Query: 418 RLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLP 476
R +P+ +AR+V ++ +P GT + + R P + NP F+P +FL
Sbjct: 361 RFGDVIPMSLARRVKKDTKF--RDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLN 418
Query: 477 ERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVISDLKESD 528
E+ + AFVPFS G R+C G A ++L + +T+++NFR+ S D
Sbjct: 419 EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKD 470
>U37143-1|AAC50370.2| 502|Homo sapiens cytochrome P450
monooxygenase CYP2J2 protein.
Length = 502
Score = 91.1 bits (216), Expect = 9e-18
Identities = 51/166 (30%), Positives = 89/166 (53%), Gaps = 5/166 (3%)
Query: 354 IMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCL 413
+ F G +TT+ + L M ++ +IQ+KV E+D++ G +P T M Y +
Sbjct: 308 LFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARE-SMPYTNAVI 366
Query: 414 METLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPD 472
E R+ +P+ + R+V + TL G +P GT ++ LHR P + P+ F+PD
Sbjct: 367 HEVQRMGNIIPLNVPREVTVDTTLA--GYHLPKGTMILTNLTALHRDPTEWATPDTFNPD 424
Query: 473 NFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNF 518
+FL E + AF+PFS G R+C+G + A +L + +++++ F
Sbjct: 425 HFL-ENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKF 469
>BC032594-1|AAH32594.1| 502|Homo sapiens cytochrome P450, family 2,
subfamily J, polypeptide 2 protein.
Length = 502
Score = 91.1 bits (216), Expect = 9e-18
Identities = 51/166 (30%), Positives = 89/166 (53%), Gaps = 5/166 (3%)
Query: 354 IMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCL 413
+ F G +TT+ + L M ++ +IQ+KV E+D++ G +P T M Y +
Sbjct: 308 LFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARE-SMPYTNAVI 366
Query: 414 METLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPD 472
E R+ +P+ + R+V + TL G +P GT ++ LHR P + P+ F+PD
Sbjct: 367 HEVQRMGNIIPLNVPREVTVDTTLA--GYHLPKGTMILTNLTALHRDPTEWATPDTFNPD 424
Query: 473 NFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNF 518
+FL E + AF+PFS G R+C+G + A +L + +++++ F
Sbjct: 425 HFL-ENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKF 469
>AY426985-1|AAQ93356.1| 502|Homo sapiens cytochrome P450, family 2,
subfamily J, polypeptide 2 protein.
Length = 502
Score = 91.1 bits (216), Expect = 9e-18
Identities = 51/166 (30%), Positives = 89/166 (53%), Gaps = 5/166 (3%)
Query: 354 IMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCL 413
+ F G +TT+ + L M ++ +IQ+KV E+D++ G +P T M Y +
Sbjct: 308 LFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARE-SMPYTNAVI 366
Query: 414 METLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPD 472
E R+ +P+ + R+V + TL G +P GT ++ LHR P + P+ F+PD
Sbjct: 367 HEVQRMGNIIPLNVPREVTVDTTLA--GYHLPKGTMILTNLTALHRDPTEWATPDTFNPD 424
Query: 473 NFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNF 518
+FL E + AF+PFS G R+C+G + A +L + +++++ F
Sbjct: 425 HFL-ENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKF 469
>AK090886-1|BAC03539.1| 337|Homo sapiens protein ( Homo sapiens
cDNA FLJ33567 fis, clone BRAMY2010272, highly similar to
Homo sapiens cholesterol 24-hydroxylase mRNA. ).
Length = 337
Score = 91.1 bits (216), Expect = 9e-18
Identities = 61/212 (28%), Positives = 108/212 (50%), Gaps = 20/212 (9%)
Query: 341 AISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTF 400
A DE + + T GH+T+A +F + + +I ++ E+D++ G S R + F
Sbjct: 133 AQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIG-SKRYLDF 191
Query: 401 QDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRP 460
+D ++YL + L E+LRLYPP R + +E + +TY + R
Sbjct: 192 EDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDG------------FSTYVMGRMD 239
Query: 461 DVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILR--NF 518
+ +P F+PD F P A + + + PFS G RSC+G+++A +++KV+++ +L+ F
Sbjct: 240 TYFEDPLTFNPDRFGP--GAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEF 297
Query: 519 RVISDLKESDFKLQADIILKRAEGFQVRLQPR 550
R++ + F LQ LK + L+PR
Sbjct: 298 RLVPGQR---FGLQEQATLKPLDPVLCTLRPR 326
>AF272142-1|AAM44456.1| 502|Homo sapiens cytochrome P450 protein.
Length = 502
Score = 91.1 bits (216), Expect = 9e-18
Identities = 51/166 (30%), Positives = 89/166 (53%), Gaps = 5/166 (3%)
Query: 354 IMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCL 413
+ F G +TT+ + L M ++ +IQ+KV E+D++ G +P T M Y +
Sbjct: 308 LFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARE-SMPYTNAVI 366
Query: 414 METLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPD 472
E R+ +P+ + R+V + TL G +P GT ++ LHR P + P+ F+PD
Sbjct: 367 HEVQRMGNIIPLNVPREVTVDTTLA--GYHLPKGTMILTNLTALHRDPTEWATPDTFNPD 424
Query: 473 NFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNF 518
+FL E + AF+PFS G R+C+G + A +L + +++++ F
Sbjct: 425 HFL-ENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKF 469
>AB080265-1|BAB85489.1| 502|Homo sapiens cytochrome P450 2J2
protein.
Length = 502
Score = 90.6 bits (215), Expect = 1e-17
Identities = 51/166 (30%), Positives = 89/166 (53%), Gaps = 5/166 (3%)
Query: 354 IMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCL 413
+ F G +TT+ + L M ++ +IQ+KV E+D++ G +P T M Y +
Sbjct: 308 LFFAGTETTSTTLRWALLYMALYPEIQEKVQVEIDRVIGQGQQPSTAARE-SMPYTNAVI 366
Query: 414 METLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPD 472
E R+ +P+ + R+V + TL G +P GT ++ LHR P + P+ F+PD
Sbjct: 367 HEVQRMGNIIPLNVPREVTVDTTLA--GYHLPKGTMILTNLTALHRDPTEWATPDTFNPD 424
Query: 473 NFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNF 518
+FL E + AF+PFS G R+C+G + A +L + +++++ F
Sbjct: 425 HFL-ENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKF 469
>M33317-1|AAA52138.1| 494|Homo sapiens CYP2A protein.
Length = 494
Score = 90.2 bits (214), Expect = 2e-17
Identities = 50/181 (27%), Positives = 93/181 (51%), Gaps = 4/181 (2%)
Query: 354 IMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCL 413
+ G +T + + ++ H +++ KV EE+D++ G + +P F+D +M Y+E +
Sbjct: 298 LFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRTKMPYMEAVI 356
Query: 414 METLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPD 472
E R +P+ +AR+V ++ +P GT + + R P + NP F+P
Sbjct: 357 HEIQRFGDVIPMSLARRVKKDTKF--RDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQ 414
Query: 473 NFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVISDLKESDFKLQ 532
+FL ++ + AFVPFS G R C G A ++L + +T+++NFR+ S D +
Sbjct: 415 HFLDDKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVS 474
Query: 533 A 533
+
Sbjct: 475 S 475
>X13897-1|CAA32097.1| 489|Homo sapiens protein ( Human mRNA for
cytochrome P-450IIA. ).
Length = 489
Score = 89.8 bits (213), Expect = 2e-17
Identities = 50/172 (29%), Positives = 91/172 (52%), Gaps = 4/172 (2%)
Query: 358 GHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMETL 417
G +T + + ++ H +++ +V EE+D++ G + +P F+D +M Y+E + E
Sbjct: 297 GTETVSTTLRYGFLLLMKHPEVEAQVHEEIDRVIGKNRQP-KFEDRAKMPYMEAVIHEIQ 355
Query: 418 RLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLP 476
R +P+ +AR+V ++ +P GT + + R P + NP F+P +FL
Sbjct: 356 RFGDVIPMSLARRVKKDTKF--RDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLN 413
Query: 477 ERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVISDLKESD 528
E+ + AFVPFS G R+C G A ++L + +T+++NFR+ S D
Sbjct: 414 EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKD 465
>BC117165-1|AAI17166.1| 494|Homo sapiens cytochrome P450, family 2,
subfamily A, polypeptide 7 protein.
Length = 494
Score = 89.8 bits (213), Expect = 2e-17
Identities = 50/176 (28%), Positives = 91/176 (51%), Gaps = 4/176 (2%)
Query: 354 IMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCL 413
+ G +T + + ++ H +++ KV EE+D++ G + +P F+D +M Y+E +
Sbjct: 298 LFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRAKMPYMEAVI 356
Query: 414 METLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPD 472
E R +P+ +AR+V ++ +P GT + + R P + NP F+P
Sbjct: 357 HEIQRFGDVIPMSLARRVKKDTKF--RDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQ 414
Query: 473 NFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVISDLKESD 528
+FL ++ + AFVPFS G R C G A ++L + +T+++NFR+ S D
Sbjct: 415 HFLDDKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTVMQNFRLKSSQSPKD 470
>AK131190-1|BAD18388.1| 372|Homo sapiens .-.-). protein.
Length = 372
Score = 89.8 bits (213), Expect = 2e-17
Identities = 55/212 (25%), Positives = 106/212 (50%), Gaps = 4/212 (1%)
Query: 341 AISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTF 400
A++ +EI V ++ G DTT+ S+ + ++ H ++Q V E+ + G+ P T
Sbjct: 164 ALTLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVP-TA 222
Query: 401 QDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRP 460
D ++ + L ETLRL+P +P R +++ + G IP GT L + Y +
Sbjct: 223 ADVPKVPLVRALLKETLRLFPVLPGNGRVTQEDLVI--GGYLIPKGTQLALCHYATSYQD 280
Query: 461 DVYPNPNKFDPDNFLPERSANR-HYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFR 519
+ +P +F P+ +L + +R + +PF G RSC+GR+ A L++ +++ +L++F
Sbjct: 281 ENFPRAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFE 340
Query: 520 VISDLKESDFKLQADIILKRAEGFQVRLQPRK 551
+ + + + + +L VR RK
Sbjct: 341 IKTSSQTNAVHAKTHGLLTPGGPIHVRFVNRK 372
>BC039307-1|AAH39307.1| 372|Homo sapiens FLJ16008 protein protein.
Length = 372
Score = 89.4 bits (212), Expect = 3e-17
Identities = 55/212 (25%), Positives = 106/212 (50%), Gaps = 4/212 (1%)
Query: 341 AISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTF 400
A++ +EI V ++ G DTT+ S+ + ++ H ++Q V E+ + G+ P T
Sbjct: 164 ALTLQEIYANVTEMLLAGVDTTSFTLSWTVYILARHPEVQQTVYREIVKNLGERHVP-TA 222
Query: 401 QDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRP 460
D ++ + L ETLRL+P +P R +++ + G IP GT L + Y +
Sbjct: 223 ADVPKVPLVRALLKETLRLFPVLPGNGRVTQEDLVI--GGYLIPKGTQLALCHYATSYQD 280
Query: 461 DVYPNPNKFDPDNFLPERSANR-HYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFR 519
+ +P +F P+ +L + +R + +PF G RSC+GR+ A L++ +++ +L++F
Sbjct: 281 ENFPRAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFE 340
Query: 520 VISDLKESDFKLQADIILKRAEGFQVRLQPRK 551
+ + + + + +L VR RK
Sbjct: 341 IKTSSQTNAVHAKTHGLLTPGGPIHVRFVNRK 372
>S67623-1|AAB29308.1| 257|Homo sapiens 25-hydroxyvitamin D
24-hydroxylase cytochrome P450 subunit protein.
Length = 257
Score = 89.0 bits (211), Expect = 4e-17
Identities = 50/179 (27%), Positives = 93/179 (51%), Gaps = 4/179 (2%)
Query: 342 ISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQ 401
+S +E+ V + +TTA + L + + +Q K+++E+ + ++ P +
Sbjct: 54 LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRA-E 112
Query: 402 DTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPD 461
D M YL+ CL E++RL P VP R +++ L +P GT L++ T L D
Sbjct: 113 DLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYA--LPKGTVLMLNTQVLGSSED 170
Query: 462 VYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV 520
+ + ++F P+ +L E+ + +A +PF G R C+GR+ A L+L + L I+R + +
Sbjct: 171 NFEDSSQFRPERWLQEKE-KINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDI 228
>AY858838-1|AAW50795.1| 372|Homo sapiens vitamin D 24-hydroxylase
splice variant protein.
Length = 372
Score = 89.0 bits (211), Expect = 4e-17
Identities = 50/179 (27%), Positives = 93/179 (51%), Gaps = 4/179 (2%)
Query: 342 ISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQ 401
+S +E+ V + +TTA + L + + +Q K+++E+ + ++ P +
Sbjct: 169 LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRA-E 227
Query: 402 DTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPD 461
D M YL+ CL E++RL P VP R +++ L +P GT L++ T L D
Sbjct: 228 DLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYA--LPKGTVLMLNTQVLGSSED 285
Query: 462 VYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV 520
+ + ++F P+ +L E+ + +A +PF G R C+GR+ A L+L + L I+R + +
Sbjct: 286 NFEDSSQFRPERWLQEKE-KINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDI 343
>AL138805-3|CAB91829.1| 514|Homo sapiens cytochrome P450, family
24, subfamily A, polypeptide 1 protein.
Length = 514
Score = 89.0 bits (211), Expect = 4e-17
Identities = 50/179 (27%), Positives = 93/179 (51%), Gaps = 4/179 (2%)
Query: 342 ISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQ 401
+S +E+ V + +TTA + L + + +Q K+++E+ + ++ P +
Sbjct: 311 LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRA-E 369
Query: 402 DTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPD 461
D M YL+ CL E++RL P VP R +++ L +P GT L++ T L D
Sbjct: 370 DLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYA--LPKGTVLMLNTQVLGSSED 427
Query: 462 VYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV 520
+ + ++F P+ +L E+ + +A +PF G R C+GR+ A L+L + L I+R + +
Sbjct: 428 NFEDSSQFRPERWLQEKE-KINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDI 485
>AL138805-1|CAM27342.1| 372|Homo sapiens cytochrome P450, family
24, subfamily A, polypeptide 1 protein.
Length = 372
Score = 89.0 bits (211), Expect = 4e-17
Identities = 50/179 (27%), Positives = 93/179 (51%), Gaps = 4/179 (2%)
Query: 342 ISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQ 401
+S +E+ V + +TTA + L + + +Q K+++E+ + ++ P +
Sbjct: 169 LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRA-E 227
Query: 402 DTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPD 461
D M YL+ CL E++RL P VP R +++ L +P GT L++ T L D
Sbjct: 228 DLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYA--LPKGTVLMLNTQVLGSSED 285
Query: 462 VYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV 520
+ + ++F P+ +L E+ + +A +PF G R C+GR+ A L+L + L I+R + +
Sbjct: 286 NFEDSSQFRPERWLQEKE-KINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDI 343
>AY513608-1|AAR90939.1| 494|Homo sapiens cytochrome P450 2A13
variant 5 protein.
Length = 494
Score = 88.6 bits (210), Expect = 5e-17
Identities = 52/176 (29%), Positives = 90/176 (51%), Gaps = 4/176 (2%)
Query: 354 IMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCL 413
+ F G +T + + ++ H +++ KV EE+D++ G + +P F+D +M Y E +
Sbjct: 298 LFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRAKMPYTEAVI 356
Query: 414 METLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPD 472
E R +P+ +A +VN++ +P GT + + R P + NP F+P
Sbjct: 357 HEIQRFGDMLPMGLAHRVNKDTKF--RDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQ 414
Query: 473 NFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVISDLKESD 528
+FL ++ + AFVPFS G R C G A ++L + +TI++NFR S D
Sbjct: 415 HFLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKD 470
>AY513606-1|AAR90937.1| 494|Homo sapiens cytochrome P450 2A13
variant 3 protein.
Length = 494
Score = 88.6 bits (210), Expect = 5e-17
Identities = 52/176 (29%), Positives = 90/176 (51%), Gaps = 4/176 (2%)
Query: 354 IMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCL 413
+ F G +T + + ++ H +++ KV EE+D++ G + +P F+D +M Y E +
Sbjct: 298 LFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRAKMPYTEAVI 356
Query: 414 METLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPD 472
E R +P+ +A +VN++ +P GT + + R P + NP F+P
Sbjct: 357 HEIQRFGDMLPMGLAHRVNKDTKF--RDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQ 414
Query: 473 NFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVISDLKESD 528
+FL ++ + AFVPFS G R C G A ++L + +TI++NFR S D
Sbjct: 415 HFLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKD 470
>AY513605-1|AAR90936.1| 494|Homo sapiens cytochrome P450 2A13
variant 2 protein.
Length = 494
Score = 88.6 bits (210), Expect = 5e-17
Identities = 52/176 (29%), Positives = 90/176 (51%), Gaps = 4/176 (2%)
Query: 354 IMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCL 413
+ F G +T + + ++ H +++ KV EE+D++ G + +P F+D +M Y E +
Sbjct: 298 LFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRAKMPYTEAVI 356
Query: 414 METLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPD 472
E R +P+ +A +VN++ +P GT + + R P + NP F+P
Sbjct: 357 HEIQRFGDMLPMGLAHRVNKDTKF--RDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQ 414
Query: 473 NFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVISDLKESD 528
+FL ++ + AFVPFS G R C G A ++L + +TI++NFR S D
Sbjct: 415 HFLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKD 470
>AY513604-1|AAR90935.1| 494|Homo sapiens cytochrome P450 2A13
variant 1 protein.
Length = 494
Score = 88.6 bits (210), Expect = 5e-17
Identities = 52/176 (29%), Positives = 90/176 (51%), Gaps = 4/176 (2%)
Query: 354 IMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCL 413
+ F G +T + + ++ H +++ KV EE+D++ G + +P F+D +M Y E +
Sbjct: 298 LFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRAKMPYTEAVI 356
Query: 414 METLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPD 472
E R +P+ +A +VN++ +P GT + + R P + NP F+P
Sbjct: 357 HEIQRFGDMLPMGLAHRVNKDTKF--RDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQ 414
Query: 473 NFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVISDLKESD 528
+FL ++ + AFVPFS G R C G A ++L + +TI++NFR S D
Sbjct: 415 HFLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKD 470
>AF209774-1|AAG35775.1| 494|Homo sapiens cytochrome P450 2A13
protein.
Length = 494
Score = 88.6 bits (210), Expect = 5e-17
Identities = 52/176 (29%), Positives = 90/176 (51%), Gaps = 4/176 (2%)
Query: 354 IMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCL 413
+ F G +T + + ++ H +++ KV EE+D++ G + +P F+D +M Y E +
Sbjct: 298 LFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRAKMPYTEAVI 356
Query: 414 METLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPD 472
E R +P+ +A +VN++ +P GT + + R P + NP F+P
Sbjct: 357 HEIQRFGDMLPMGLAHRVNKDTKF--RDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQ 414
Query: 473 NFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVISDLKESD 528
+FL ++ + AFVPFS G R C G A ++L + +TI++NFR S D
Sbjct: 415 HFLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKD 470
>X55764-1|CAA39290.1| 503|Homo sapiens protein ( Human mRNA for
cytochrome P-450 (11 Beta). ).
Length = 503
Score = 88.2 bits (209), Expect = 7e-17
Identities = 59/198 (29%), Positives = 100/198 (50%), Gaps = 7/198 (3%)
Query: 342 ISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEE-LDQIFGDSDRPVTF 400
+S + IK + DTT L + + ++Q + +E L S+ P
Sbjct: 299 LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQ-- 356
Query: 401 QDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRP 460
+ T E+ L L ETLRLYP + R V+ ++ L + IPAGT + + Y L R P
Sbjct: 357 KATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNY--HIPAGTLVRVFLYSLGRNP 414
Query: 461 DVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV 520
++P P +++P +L R + R++Y VPF G R C+GR+ A ++ ++L +L++ +V
Sbjct: 415 ALFPRPERYNPQRWLDIRGSGRNFY-HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQV 473
Query: 521 ISDLKESDFKLQADIILK 538
L + D K+ IL+
Sbjct: 474 -ETLTQEDIKMVYSFILR 490
>X54741-1|CAA38539.1| 503|Homo sapiens aldosterone synthase
(P-450aldo) protein.
Length = 503
Score = 88.2 bits (209), Expect = 7e-17
Identities = 60/198 (30%), Positives = 101/198 (51%), Gaps = 7/198 (3%)
Query: 342 ISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEE-LDQIFGDSDRPVTF 400
+S E IK + DTTA L + + D+Q + +E L S+ P
Sbjct: 299 LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQ-- 356
Query: 401 QDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRP 460
+ T E+ L L ETLRLYP + R V+ ++ L + IPAGT + + Y L R
Sbjct: 357 KATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNY--HIPAGTLVQVFLYSLGRNA 414
Query: 461 DVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV 520
++P P +++P +L R + R+++ VPF G R C+GR+ A ++ ++L +L++F +
Sbjct: 415 ALFPRPERYNPQRWLDIRGSGRNFH-HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF-L 472
Query: 521 ISDLKESDFKLQADIILK 538
+ L + D K+ IL+
Sbjct: 473 VETLTQEDIKMVYSFILR 490
>M29874-1|AAA52144.1| 491|Homo sapiens CYP2B protein.
Length = 491
Score = 88.2 bits (209), Expect = 7e-17
Identities = 60/220 (27%), Positives = 100/220 (45%), Gaps = 6/220 (2%)
Query: 334 ESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGD 393
E S + S + + ++ F G +TT+ + +M + + ++V E++Q+ G
Sbjct: 275 EKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGP 334
Query: 394 SDRPVTFQDTLEMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIA 452
RP D +M Y E + E R +P+ + V Q + G IP T + +
Sbjct: 335 H-RPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSF--RGYIIPKDTEVFLI 391
Query: 453 TYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILS 512
P + P+ F+PD+FL A + AF+PFS G R C+G A +L + +
Sbjct: 392 LSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFT 451
Query: 513 TILRNFRVISDLKESDFKL--QADIILKRAEGFQVRLQPR 550
TIL+NF + S + D L Q + K +Q+R PR
Sbjct: 452 TILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491
>D13752-1|BAA02899.1| 503|Homo sapiens steroid 18-hydroxylase
protein.
Length = 503
Score = 88.2 bits (209), Expect = 7e-17
Identities = 60/198 (30%), Positives = 101/198 (51%), Gaps = 7/198 (3%)
Query: 342 ISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEE-LDQIFGDSDRPVTF 400
+S E IK + DTTA L + + D+Q + +E L S+ P
Sbjct: 299 LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQ-- 356
Query: 401 QDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRP 460
+ T E+ L L ETLRLYP + R V+ ++ L + IPAGT + + Y L R
Sbjct: 357 KATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNY--HIPAGTLVQVFLYSLGRNA 414
Query: 461 DVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV 520
++P P +++P +L R + R+++ VPF G R C+GR+ A ++ ++L +L++F +
Sbjct: 415 ALFPRPERYNPQRWLDIRGSGRNFH-HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF-L 472
Query: 521 ISDLKESDFKLQADIILK 538
+ L + D K+ IL+
Sbjct: 473 VETLTQEDIKMVYSFILR 490
>DQ298753-1|ABB84469.1| 491|Homo sapiens cytochrome P450, family 2,
subfamily B, polypeptide 6 protein.
Length = 491
Score = 88.2 bits (209), Expect = 7e-17
Identities = 60/220 (27%), Positives = 100/220 (45%), Gaps = 6/220 (2%)
Query: 334 ESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGD 393
E S + S + + ++ F G +TT+ + +M + + ++V E++Q+ G
Sbjct: 275 EKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGP 334
Query: 394 SDRPVTFQDTLEMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIA 452
RP D +M Y E + E R +P+ + V Q + G IP T + +
Sbjct: 335 H-RPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSF--RGYIIPKDTEVFLI 391
Query: 453 TYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILS 512
P + P+ F+PD+FL A + AF+PFS G R C+G A +L + +
Sbjct: 392 LSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFT 451
Query: 513 TILRNFRVISDLKESDFKL--QADIILKRAEGFQVRLQPR 550
TIL+NF + S + D L Q + K +Q+R PR
Sbjct: 452 TILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491
>BC067431-1|AAH67431.1| 491|Homo sapiens cytochrome P450, family 2,
subfamily B, polypeptide 6 protein.
Length = 491
Score = 88.2 bits (209), Expect = 7e-17
Identities = 60/220 (27%), Positives = 100/220 (45%), Gaps = 6/220 (2%)
Query: 334 ESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGD 393
E S + S + + ++ F G +TT+ + +M + + ++V E++Q+ G
Sbjct: 275 EKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGP 334
Query: 394 SDRPVTFQDTLEMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIA 452
RP D +M Y E + E R +P+ + V Q + G IP T + +
Sbjct: 335 H-RPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSF--RGYIIPKDTEVFLI 391
Query: 453 TYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILS 512
P + P+ F+PD+FL A + AF+PFS G R C+G A +L + +
Sbjct: 392 LSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFT 451
Query: 513 TILRNFRVISDLKESDFKL--QADIILKRAEGFQVRLQPR 550
TIL+NF + S + D L Q + K +Q+R PR
Sbjct: 452 TILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491
>BC067430-1|AAH67430.1| 491|Homo sapiens cytochrome P450, family 2,
subfamily B, polypeptide 6 protein.
Length = 491
Score = 88.2 bits (209), Expect = 7e-17
Identities = 60/220 (27%), Positives = 100/220 (45%), Gaps = 6/220 (2%)
Query: 334 ESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGD 393
E S + S + + ++ F G +TT+ + +M + + ++V E++Q+ G
Sbjct: 275 EKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGP 334
Query: 394 SDRPVTFQDTLEMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIA 452
RP D +M Y E + E R +P+ + V Q + G IP T + +
Sbjct: 335 H-RPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSF--RGYIIPKDTEVFLI 391
Query: 453 TYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILS 512
P + P+ F+PD+FL A + AF+PFS G R C+G A +L + +
Sbjct: 392 LSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFT 451
Query: 513 TILRNFRVISDLKESDFKL--QADIILKRAEGFQVRLQPR 550
TIL+NF + S + D L Q + K +Q+R PR
Sbjct: 452 TILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491
>AY513609-1|AAR90940.1| 494|Homo sapiens cytochrome P450 2A13
variant 6 protein.
Length = 494
Score = 88.2 bits (209), Expect = 7e-17
Identities = 52/176 (29%), Positives = 90/176 (51%), Gaps = 4/176 (2%)
Query: 354 IMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCL 413
+ F G +T + + ++ H +++ KV EE+D++ G + +P F+D +M Y E +
Sbjct: 298 LFFAGTETVSTTLRYGFLLLMKHPELEAKVHEEIDRVIGKNRQP-KFEDRAKMPYTEAVI 356
Query: 414 METLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPD 472
E R +P+ +A +VN++ +P GT + + R P + NP F+P
Sbjct: 357 HEIQRFGDMLPMGLAHRVNKDTKF--RDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQ 414
Query: 473 NFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVISDLKESD 528
+FL ++ + AFVPFS G R C G A ++L + +TI++NFR S D
Sbjct: 415 HFLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKD 470
>AF182277-1|AAF13602.1| 491|Homo sapiens cytochrome P450-2B6
protein.
Length = 491
Score = 88.2 bits (209), Expect = 7e-17
Identities = 60/220 (27%), Positives = 100/220 (45%), Gaps = 6/220 (2%)
Query: 334 ESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGD 393
E S + S + + ++ F G +TT+ + +M + + ++V E++Q+ G
Sbjct: 275 EKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGP 334
Query: 394 SDRPVTFQDTLEMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIA 452
RP D +M Y E + E R +P+ + V Q + G IP T + +
Sbjct: 335 H-RPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSF--RGYIIPKDTEVFLI 391
Query: 453 TYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILS 512
P + P+ F+PD+FL A + AF+PFS G R C+G A +L + +
Sbjct: 392 LSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFT 451
Query: 513 TILRNFRVISDLKESDFKL--QADIILKRAEGFQVRLQPR 550
TIL+NF + S + D L Q + K +Q+R PR
Sbjct: 452 TILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491
>AC023172-1|AAF32444.1| 491|Homo sapiens CYP2B6 protein.
Length = 491
Score = 88.2 bits (209), Expect = 7e-17
Identities = 60/220 (27%), Positives = 100/220 (45%), Gaps = 6/220 (2%)
Query: 334 ESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGD 393
E S + S + + ++ F G +TT+ + +M + + ++V E++Q+ G
Sbjct: 275 EKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGP 334
Query: 394 SDRPVTFQDTLEMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIA 452
RP D +M Y E + E R +P+ + V Q + G IP T + +
Sbjct: 335 H-RPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSF--RGYIIPKDTEVFLI 391
Query: 453 TYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILS 512
P + P+ F+PD+FL A + AF+PFS G R C+G A +L + +
Sbjct: 392 LSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFT 451
Query: 513 TILRNFRVISDLKESDFKL--QADIILKRAEGFQVRLQPR 550
TIL+NF + S + D L Q + K +Q+R PR
Sbjct: 452 TILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491
>DQ282151-1|ABB77899.1| 496|Homo sapiens cytochrome P450 2D6
protein.
Length = 496
Score = 87.8 bits (208), Expect = 9e-17
Identities = 55/193 (28%), Positives = 98/193 (50%), Gaps = 4/193 (2%)
Query: 327 AFLDLLLESSQSGVAISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEE 386
AFL + + +DE ++ V + G TT+ ++ L +M +H D+Q +V +E
Sbjct: 274 AFLAEMEAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQE 333
Query: 387 LDQIFGDSDRPVTFQDTLEMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPA 445
+D + G RP D M Y + E R VP+ + +++I + G +IP
Sbjct: 334 IDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIPK 390
Query: 446 GTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAML 505
GTTL+ + + V+ P +F P++FL + AF+PFSAG R+C+G A +
Sbjct: 391 GTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARM 450
Query: 506 KLKVILSTILRNF 518
+L + +++L++F
Sbjct: 451 ELFLFFTSLLQHF 463
>M33388-1|AAA53500.1| 497|Homo sapiens cytochrome P450 IID6
protein.
Length = 497
Score = 87.0 bits (206), Expect = 2e-16
Identities = 52/179 (29%), Positives = 94/179 (52%), Gaps = 4/179 (2%)
Query: 341 AISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTF 400
+ +DE ++ V + G TT+ ++ L +M +H D+Q +V +E+D + G RP
Sbjct: 289 SFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EM 347
Query: 401 QDTLEMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRR 459
D M Y + E R VP+ + +++I + G +IP GTTL+ + +
Sbjct: 348 GDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIPKGTTLITNLSSVLKD 405
Query: 460 PDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNF 518
V+ P +F P++FL + AF+PFSAG R+C+G A ++L + +++L++F
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>M33189-1|AAA35737.1| 500|Homo sapiens protein ( Human debrisoquine
4-hydroxylase mutant allele (CYP2D6-MA1) gene, complete
cds. ).
Length = 500
Score = 87.0 bits (206), Expect = 2e-16
Identities = 52/179 (29%), Positives = 94/179 (52%), Gaps = 4/179 (2%)
Query: 341 AISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTF 400
+ +DE ++ V + G TT+ ++ L +M +H D+Q +V +E+D + G RP
Sbjct: 292 SFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EM 350
Query: 401 QDTLEMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRR 459
D M Y + E R VP+ + +++I + G +IP GTTL+ + +
Sbjct: 351 GDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIPKGTTLITNLSSVLKD 408
Query: 460 PDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNF 518
V+ P +F P++FL + AF+PFSAG R+C+G A ++L + +++L++F
Sbjct: 409 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 467
>M24499-1|AAA36403.1| 373|Homo sapiens cytochrome P450db1 protein.
Length = 373
Score = 87.0 bits (206), Expect = 2e-16
Identities = 52/179 (29%), Positives = 94/179 (52%), Gaps = 4/179 (2%)
Query: 341 AISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTF 400
+ +DE ++ V + G TT+ ++ L +M +H D+Q +V +E+D + G RP
Sbjct: 165 SFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EM 223
Query: 401 QDTLEMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRR 459
D M Y + E R VP+ + +++I + G +IP GTTL+ + +
Sbjct: 224 GDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIPKGTTLITNLSSVLKD 281
Query: 460 PDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNF 518
V+ P +F P++FL + AF+PFSAG R+C+G A ++L + +++L++F
Sbjct: 282 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 340
>DQ282154-1|ABB77902.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 87.0 bits (206), Expect = 2e-16
Identities = 52/179 (29%), Positives = 94/179 (52%), Gaps = 4/179 (2%)
Query: 341 AISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTF 400
+ +DE ++ V + G TT+ ++ L +M +H D+Q +V +E+D + G RP
Sbjct: 289 SFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EM 347
Query: 401 QDTLEMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRR 459
D M Y + E R VP+ + +++I + G +IP GTTL+ + +
Sbjct: 348 GDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIPKGTTLITNLSSVLKD 405
Query: 460 PDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNF 518
V+ P +F P++FL + AF+PFSAG R+C+G A ++L + +++L++F
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>DQ282152-1|ABB77900.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 87.0 bits (206), Expect = 2e-16
Identities = 52/179 (29%), Positives = 94/179 (52%), Gaps = 4/179 (2%)
Query: 341 AISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTF 400
+ +DE ++ V + G TT+ ++ L +M +H D+Q +V +E+D + G RP
Sbjct: 289 SFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EM 347
Query: 401 QDTLEMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRR 459
D M Y + E R VP+ + +++I + G +IP GTTL+ + +
Sbjct: 348 GDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIPKGTTLITNLSSVLKD 405
Query: 460 PDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNF 518
V+ P +F P++FL + AF+PFSAG R+C+G A ++L + +++L++F
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>DQ282146-1|ABB77897.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 87.0 bits (206), Expect = 2e-16
Identities = 52/179 (29%), Positives = 94/179 (52%), Gaps = 4/179 (2%)
Query: 341 AISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTF 400
+ +DE ++ V + G TT+ ++ L +M +H D+Q +V +E+D + G RP
Sbjct: 289 SFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EM 347
Query: 401 QDTLEMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRR 459
D M Y + E R VP+ + +++I + G +IP GTTL+ + +
Sbjct: 348 GDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIPKGTTLITNLSSVLKD 405
Query: 460 PDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNF 518
V+ P +F P++FL + AF+PFSAG R+C+G A ++L + +++L++F
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>DQ282145-1|ABB77896.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 87.0 bits (206), Expect = 2e-16
Identities = 52/179 (29%), Positives = 94/179 (52%), Gaps = 4/179 (2%)
Query: 341 AISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTF 400
+ +DE ++ V + G TT+ ++ L +M +H D+Q +V +E+D + G RP
Sbjct: 289 SFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EM 347
Query: 401 QDTLEMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRR 459
D M Y + E R VP+ + +++I + G +IP GTTL+ + +
Sbjct: 348 GDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIPKGTTLITNLSSVLKD 405
Query: 460 PDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNF 518
V+ P +F P++FL + AF+PFSAG R+C+G A ++L + +++L++F
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>DQ282144-1|ABB77895.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 87.0 bits (206), Expect = 2e-16
Identities = 52/179 (29%), Positives = 94/179 (52%), Gaps = 4/179 (2%)
Query: 341 AISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTF 400
+ +DE ++ V + G TT+ ++ L +M +H D+Q +V +E+D + G RP
Sbjct: 289 SFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EM 347
Query: 401 QDTLEMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRR 459
D M Y + E R VP+ + +++I + G +IP GTTL+ + +
Sbjct: 348 GDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIPKGTTLITNLSSVLKD 405
Query: 460 PDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNF 518
V+ P +F P++FL + AF+PFSAG R+C+G A ++L + +++L++F
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>DQ211354-2|ABB01372.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 87.0 bits (206), Expect = 2e-16
Identities = 52/179 (29%), Positives = 94/179 (52%), Gaps = 4/179 (2%)
Query: 341 AISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTF 400
+ +DE ++ V + G TT+ ++ L +M +H D+Q +V +E+D + G RP
Sbjct: 289 SFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EM 347
Query: 401 QDTLEMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRR 459
D M Y + E R VP+ + +++I + G +IP GTTL+ + +
Sbjct: 348 GDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIPKGTTLITNLSSVLKD 405
Query: 460 PDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNF 518
V+ P +F P++FL + AF+PFSAG R+C+G A ++L + +++L++F
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>DQ211353-2|ABB01371.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 87.0 bits (206), Expect = 2e-16
Identities = 52/179 (29%), Positives = 94/179 (52%), Gaps = 4/179 (2%)
Query: 341 AISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTF 400
+ +DE ++ V + G TT+ ++ L +M +H D+Q +V +E+D + G RP
Sbjct: 289 SFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EM 347
Query: 401 QDTLEMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRR 459
D M Y + E R VP+ + +++I + G +IP GTTL+ + +
Sbjct: 348 GDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIPKGTTLITNLSSVLKD 405
Query: 460 PDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNF 518
V+ P +F P++FL + AF+PFSAG R+C+G A ++L + +++L++F
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>DQ211353-1|ABB01370.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 87.0 bits (206), Expect = 2e-16
Identities = 52/179 (29%), Positives = 94/179 (52%), Gaps = 4/179 (2%)
Query: 341 AISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTF 400
+ +DE ++ V + G TT+ ++ L +M +H D+Q +V +E+D + G RP
Sbjct: 289 SFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EM 347
Query: 401 QDTLEMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRR 459
D M Y + E R VP+ + +++I + G +IP GTTL+ + +
Sbjct: 348 GDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIPKGTTLITNLSSVLKD 405
Query: 460 PDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNF 518
V+ P +F P++FL + AF+PFSAG R+C+G A ++L + +++L++F
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>BC075024-1|AAH75024.1| 497|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 497
Score = 87.0 bits (206), Expect = 2e-16
Identities = 52/179 (29%), Positives = 94/179 (52%), Gaps = 4/179 (2%)
Query: 341 AISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTF 400
+ +DE ++ V + G TT+ ++ L +M +H D+Q +V +E+D + G RP
Sbjct: 289 SFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EM 347
Query: 401 QDTLEMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRR 459
D M Y + E R VP+ + +++I + G +IP GTTL+ + +
Sbjct: 348 GDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIPKGTTLITNLSSVLKD 405
Query: 460 PDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNF 518
V+ P +F P++FL + AF+PFSAG R+C+G A ++L + +++L++F
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>BC075023-1|AAH75023.1| 497|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 497
Score = 87.0 bits (206), Expect = 2e-16
Identities = 52/179 (29%), Positives = 94/179 (52%), Gaps = 4/179 (2%)
Query: 341 AISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTF 400
+ +DE ++ V + G TT+ ++ L +M +H D+Q +V +E+D + G RP
Sbjct: 289 SFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EM 347
Query: 401 QDTLEMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRR 459
D M Y + E R VP+ + +++I + G +IP GTTL+ + +
Sbjct: 348 GDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIPKGTTLITNLSSVLKD 405
Query: 460 PDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNF 518
V+ P +F P++FL + AF+PFSAG R+C+G A ++L + +++L++F
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>AY545216-1|AAS55001.1| 497|Homo sapiens cytochrome P4502D6
protein.
Length = 497
Score = 87.0 bits (206), Expect = 2e-16
Identities = 52/179 (29%), Positives = 94/179 (52%), Gaps = 4/179 (2%)
Query: 341 AISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTF 400
+ +DE ++ V + G TT+ ++ L +M +H D+Q +V +E+D + G RP
Sbjct: 289 SFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EM 347
Query: 401 QDTLEMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRR 459
D M Y + E R VP+ + +++I + G +IP GTTL+ + +
Sbjct: 348 GDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIPKGTTLITNLSSVLKD 405
Query: 460 PDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNF 518
V+ P +F P++FL + AF+PFSAG R+C+G A ++L + +++L++F
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>AF478474-1|AAL84813.1| 503|Homo sapiens mutated cytochrome
P-450c11 protein protein.
Length = 503
Score = 87.0 bits (206), Expect = 2e-16
Identities = 58/198 (29%), Positives = 99/198 (50%), Gaps = 7/198 (3%)
Query: 342 ISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEE-LDQIFGDSDRPVTF 400
+S + IK + DTT L + + ++Q + +E L S+ P
Sbjct: 299 LSPDAIKANSMELTAGSMDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQ-- 356
Query: 401 QDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRP 460
+ T E+ L L ETLRLYP + R + ++ L + IPAGT + + Y L R P
Sbjct: 357 KATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNY--HIPAGTLVRVFLYSLGRNP 414
Query: 461 DVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV 520
++P P +++P +L R + R++Y VPF G R C+GR+ A ++ ++L +L++ +V
Sbjct: 415 ALFPRPERYNPQRWLDIRGSGRNFY-HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQV 473
Query: 521 ISDLKESDFKLQADIILK 538
L + D K+ IL+
Sbjct: 474 -ETLTQEDIKMVYSFILR 490
>AB209492-1|BAD92729.1| 566|Homo sapiens Debrisoquine 4-hydroxylase
mutant allele variant protein.
Length = 566
Score = 87.0 bits (206), Expect = 2e-16
Identities = 52/179 (29%), Positives = 94/179 (52%), Gaps = 4/179 (2%)
Query: 341 AISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTF 400
+ +DE ++ V + G TT+ ++ L +M +H D+Q +V +E+D + G RP
Sbjct: 358 SFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EM 416
Query: 401 QDTLEMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRR 459
D M Y + E R VP+ + +++I + G +IP GTTL+ + +
Sbjct: 417 GDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIPKGTTLITNLSSVLKD 474
Query: 460 PDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNF 518
V+ P +F P++FL + AF+PFSAG R+C+G A ++L + +++L++F
Sbjct: 475 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 533
>Y00498-1|CAA68550.1| 490|Homo sapiens IIC2 protein.
Length = 490
Score = 86.6 bits (205), Expect = 2e-16
Identities = 64/210 (30%), Positives = 100/210 (47%), Gaps = 10/210 (4%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
E + V + G +TT+ + L ++ H ++ KV EE+D + G P QD
Sbjct: 285 ENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPC-MQDRS 343
Query: 405 EMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKK--IPAGTTLV-IATYKLHRRPD 461
M Y + + E R VP V +T + + IP GTT++ + T LH +
Sbjct: 344 HMPYTDAVVHEIQRYSDLVPT---GVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKE 400
Query: 462 VYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV- 520
+PNPN FDP +FL + + F+PFSAG R C G A ++L + L+TIL+NF +
Sbjct: 401 -FPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLK 459
Query: 521 -ISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ DLK + I+ +Q+ P
Sbjct: 460 SVDDLKNLNTTAVTKGIVSLPPSYQICFIP 489
>X58906-1|CAA41709.1| 495|Homo sapiens steroid 21-monooxygenase
protein.
Length = 495
Score = 86.6 bits (205), Expect = 2e-16
Identities = 67/203 (33%), Positives = 100/203 (49%), Gaps = 13/203 (6%)
Query: 354 IMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGD--SDRPVTFQDTLEMKYLER 411
++ G +TTA S+ + + H +IQ ++ EELD G S V ++D + L
Sbjct: 289 LLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDHARLPLLNA 348
Query: 412 CLMETLRLYPPVPIIARQVNQEITLPSN--GKKIPAGTTLVIATYKLHRRPDVYPNPNKF 469
+ E LRL P VP+ + T PS+ G IP GT ++ H V+ P++F
Sbjct: 349 TIAEVLRLRPVVPLA---LPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEF 405
Query: 470 DPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVIS--DLKES 527
PD FL E N AF G R C+G A L+L V+L+ +L+ F ++S D S
Sbjct: 406 WPDRFL-EPGKNSRALAF---GCGARVCLGEPLARLELFVVLTRLLQAFTLLSSGDALPS 461
Query: 528 DFKLQADIILKRAEGFQVRLQPR 550
L ++ + + FQVRLQPR
Sbjct: 462 LQPLPHCSVILKMQPFQVRLQPR 484
>M32879-1|AAA52149.1| 503|Homo sapiens CYP11B1 protein.
Length = 503
Score = 86.6 bits (205), Expect = 2e-16
Identities = 58/198 (29%), Positives = 99/198 (50%), Gaps = 7/198 (3%)
Query: 342 ISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEE-LDQIFGDSDRPVTF 400
+S + IK + DTT L + + ++Q + +E L S+ P
Sbjct: 299 LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQ-- 356
Query: 401 QDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRP 460
+ T E+ L L ETLRLYP + R + ++ L + IPAGT + + Y L R P
Sbjct: 357 KATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNY--HIPAGTLVRVFLYSLGRNP 414
Query: 461 DVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV 520
++P P +++P +L R + R++Y VPF G R C+GR+ A ++ ++L +L++ +V
Sbjct: 415 ALFPRPERYNPQRWLDIRGSGRNFY-HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQV 473
Query: 521 ISDLKESDFKLQADIILK 538
L + D K+ IL+
Sbjct: 474 -ETLTQEDIKMVYSFILR 490
>M21942-1|AAA52161.1| 462|Homo sapiens CYP2C protein.
Length = 462
Score = 86.6 bits (205), Expect = 2e-16
Identities = 64/210 (30%), Positives = 100/210 (47%), Gaps = 10/210 (4%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
E + V + G +TT+ + L ++ H ++ KV EE+D + G P QD
Sbjct: 257 ENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPC-MQDRS 315
Query: 405 EMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKK--IPAGTTLV-IATYKLHRRPD 461
M Y + + E R VP V +T + + IP GTT++ + T LH +
Sbjct: 316 HMPYTDAVVHEIQRYSDLVPT---GVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKE 372
Query: 462 VYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV- 520
+PNPN FDP +FL + + F+PFSAG R C G A ++L + L+TIL+NF +
Sbjct: 373 -FPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLK 431
Query: 521 -ISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ DLK + I+ +Q+ P
Sbjct: 432 SVDDLKNLNTTAVTKGIVSLPPSYQICFIP 461
>M17397-1|AAA35739.1| 490|Homo sapiens protein ( Human cytochrome
P-450 1 functional form mRNA, complete cds. ).
Length = 490
Score = 86.6 bits (205), Expect = 2e-16
Identities = 64/210 (30%), Positives = 100/210 (47%), Gaps = 10/210 (4%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
E + V + G +TT+ + L ++ H ++ KV EE+D + G P QD
Sbjct: 285 ENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPC-MQDRS 343
Query: 405 EMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKK--IPAGTTLV-IATYKLHRRPD 461
M Y + + E R VP V +T + + IP GTT++ + T LH +
Sbjct: 344 HMPYTDAVVHEIQRYSDLVPT---GVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKE 400
Query: 462 VYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV- 520
+PNPN FDP +FL + + F+PFSAG R C G A ++L + L+TIL+NF +
Sbjct: 401 -FPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLK 459
Query: 521 -ISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ DLK + I+ +Q+ P
Sbjct: 460 SVDDLKNLNTTAVTKGIVSLPPSYQICFIP 489
>BC096287-1|AAH96287.1| 503|Homo sapiens cytochrome P450, family
11, subfamily B, polypeptide 1 protein.
Length = 503
Score = 86.6 bits (205), Expect = 2e-16
Identities = 58/198 (29%), Positives = 99/198 (50%), Gaps = 7/198 (3%)
Query: 342 ISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEE-LDQIFGDSDRPVTF 400
+S + IK + DTT L + + ++Q + +E L S+ P
Sbjct: 299 LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQ-- 356
Query: 401 QDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRP 460
+ T E+ L L ETLRLYP + R + ++ L + IPAGT + + Y L R P
Sbjct: 357 KATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNY--HIPAGTLVRVFLYSLGRNP 414
Query: 461 DVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV 520
++P P +++P +L R + R++Y VPF G R C+GR+ A ++ ++L +L++ +V
Sbjct: 415 ALFPRPERYNPQRWLDIRGSGRNFY-HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQV 473
Query: 521 ISDLKESDFKLQADIILK 538
L + D K+ IL+
Sbjct: 474 -ETLTQEDIKMVYSFILR 490
>BC096285-1|AAH96285.1| 574|Homo sapiens CYP11B1 protein protein.
Length = 574
Score = 86.6 bits (205), Expect = 2e-16
Identities = 58/198 (29%), Positives = 99/198 (50%), Gaps = 7/198 (3%)
Query: 342 ISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEE-LDQIFGDSDRPVTF 400
+S + IK + DTT L + + ++Q + +E L S+ P
Sbjct: 370 LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQ-- 427
Query: 401 QDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRP 460
+ T E+ L L ETLRLYP + R + ++ L + IPAGT + + Y L R P
Sbjct: 428 KATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNY--HIPAGTLVRVFLYSLGRNP 485
Query: 461 DVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV 520
++P P +++P +L R + R++Y VPF G R C+GR+ A ++ ++L +L++ +V
Sbjct: 486 ALFPRPERYNPQRWLDIRGSGRNFY-HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQV 544
Query: 521 ISDLKESDFKLQADIILK 538
L + D K+ IL+
Sbjct: 545 -ETLTQEDIKMVYSFILR 561
>BC020596-1|AAH20596.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 8 protein.
Length = 490
Score = 86.6 bits (205), Expect = 2e-16
Identities = 64/210 (30%), Positives = 100/210 (47%), Gaps = 10/210 (4%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
E + V + G +TT+ + L ++ H ++ KV EE+D + G P QD
Sbjct: 285 ENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPC-MQDRS 343
Query: 405 EMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKK--IPAGTTLV-IATYKLHRRPD 461
M Y + + E R VP V +T + + IP GTT++ + T LH +
Sbjct: 344 HMPYTDAVVHEIQRYSDLVPT---GVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKE 400
Query: 462 VYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV- 520
+PNPN FDP +FL + + F+PFSAG R C G A ++L + L+TIL+NF +
Sbjct: 401 -FPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLK 459
Query: 521 -ISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ DLK + I+ +Q+ P
Sbjct: 460 SVDDLKNLNTTAVTKGIVSLPPSYQICFIP 489
>AY514490-1|AAR89907.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 8 protein.
Length = 490
Score = 86.6 bits (205), Expect = 2e-16
Identities = 64/210 (30%), Positives = 100/210 (47%), Gaps = 10/210 (4%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
E + V + G +TT+ + L ++ H ++ KV EE+D + G P QD
Sbjct: 285 ENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPC-MQDRS 343
Query: 405 EMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKK--IPAGTTLV-IATYKLHRRPD 461
M Y + + E R VP V +T + + IP GTT++ + T LH +
Sbjct: 344 HMPYTDAVVHEIQRYSDLVPT---GVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKE 400
Query: 462 VYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV- 520
+PNPN FDP +FL + + F+PFSAG R C G A ++L + L+TIL+NF +
Sbjct: 401 -FPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLK 459
Query: 521 -ISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ DLK + I+ +Q+ P
Sbjct: 460 SVDDLKNLNTTAVTKGIVSLPPSYQICFIP 489
>AL359672-5|CAH71307.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 8 protein.
Length = 490
Score = 86.6 bits (205), Expect = 2e-16
Identities = 64/210 (30%), Positives = 100/210 (47%), Gaps = 10/210 (4%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
E + V + G +TT+ + L ++ H ++ KV EE+D + G P QD
Sbjct: 285 ENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPC-MQDRS 343
Query: 405 EMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKK--IPAGTTLV-IATYKLHRRPD 461
M Y + + E R VP V +T + + IP GTT++ + T LH +
Sbjct: 344 HMPYTDAVVHEIQRYSDLVPT---GVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKE 400
Query: 462 VYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV- 520
+PNPN FDP +FL + + F+PFSAG R C G A ++L + L+TIL+NF +
Sbjct: 401 -FPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLK 459
Query: 521 -ISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ DLK + I+ +Q+ P
Sbjct: 460 SVDDLKNLNTTAVTKGIVSLPPSYQICFIP 489
>X51535-1|CAA35915.1| 210|Homo sapiens cytochrome P-450 HPH (120
AA) protein.
Length = 210
Score = 86.2 bits (204), Expect = 3e-16
Identities = 64/210 (30%), Positives = 100/210 (47%), Gaps = 10/210 (4%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
E + V + G +TT+ + L ++ H ++ KV EE+D + G P QD
Sbjct: 5 ENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPC-MQDRS 63
Query: 405 EMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKK--IPAGTTLV-IATYKLHRRPD 461
M Y + + E R VP V +T + + IP GTT++ + T LH +
Sbjct: 64 HMPYTDAVVHEIQRYSDLVPT---GVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDRE 120
Query: 462 VYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV- 520
+PNPN FDP +FL + + F+PFSAG R C G A ++L + L+TIL+NF +
Sbjct: 121 -FPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLK 179
Query: 521 -ISDLKESDFKLQADIILKRAEGFQVRLQP 549
+ DLK + I+ +Q+ P
Sbjct: 180 SVDDLKNLNTTAVTKGIVSLPPSYQICFIP 209
>X08006-1|CAA30807.1| 497|Homo sapiens cytochrome P450 db1 protein.
Length = 497
Score = 86.2 bits (204), Expect = 3e-16
Identities = 52/179 (29%), Positives = 94/179 (52%), Gaps = 4/179 (2%)
Query: 341 AISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTF 400
+ +DE ++ V + G TT+ ++ L +M +H D+Q +V +E+D + G RP
Sbjct: 289 SFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EM 347
Query: 401 QDTLEMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRR 459
D M Y + E R VP+ + +++I + G +IP GTTL+ + +
Sbjct: 348 GDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEV--QGFRIPKGTTLITNLSSVLKD 405
Query: 460 PDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNF 518
V+ P +F P++FL + AF+PFSAG R+C+G A ++L + +++L++F
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>M20403-1|AAA52153.1| 497|Homo sapiens CYP2D protein.
Length = 497
Score = 86.2 bits (204), Expect = 3e-16
Identities = 52/179 (29%), Positives = 94/179 (52%), Gaps = 4/179 (2%)
Query: 341 AISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTF 400
+ +DE ++ V + G TT+ ++ L +M +H D+Q +V +E+D + G RP
Sbjct: 289 SFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EM 347
Query: 401 QDTLEMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRR 459
D M Y + E R VP+ + +++I + G +IP GTTL+ + +
Sbjct: 348 GDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEV--QGFRIPKGTTLITNLSSVLKD 405
Query: 460 PDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNF 518
V+ P +F P++FL + AF+PFSAG R+C+G A ++L + +++L++F
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>M32881-1|AAA35741.1| 503|Homo sapiens protein ( Human steroid
11-beta-hydroxylase-like-enzyme (CYP11B2) gene, exon 9.
).
Length = 503
Score = 85.8 bits (203), Expect = 4e-16
Identities = 60/198 (30%), Positives = 99/198 (50%), Gaps = 7/198 (3%)
Query: 342 ISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEE-LDQIFGDSDRPVTF 400
+S E IK + DTTA L + + D+Q + +E L S+ P
Sbjct: 299 LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRKESLAAAASISEHPQ-- 356
Query: 401 QDTLEMKYLERCLMETLRLYPPVPIIARQVNQEITLPSNGKKIPAGTTLVIATYKLHRRP 460
+ T E+ L L ETLRLYP + R V+ ++ L + IPAGT + + Y L R
Sbjct: 357 KATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNY--HIPAGTLVQVFLYSLGRNA 414
Query: 461 DVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRV 520
++P P +++P +L R + R+ + VPF G R C+GR+ A ++ ++L +L+ F +
Sbjct: 415 ALFPRPERYNPQRWLDIRGSGRNLH-HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKRF-L 472
Query: 521 ISDLKESDFKLQADIILK 538
+ L + D K+ IL+
Sbjct: 473 VETLTQEDIKMVYSFILR 490
>BC106758-1|AAI06759.1| 497|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 497
Score = 85.8 bits (203), Expect = 4e-16
Identities = 52/179 (29%), Positives = 94/179 (52%), Gaps = 4/179 (2%)
Query: 341 AISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTF 400
+ +DE + V + G TT+ ++ L +M +H D+Q +V +E+D++ G RP
Sbjct: 289 SFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDEVIGQVRRP-EM 347
Query: 401 QDTLEMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIATYKLHRR 459
D M Y + E R VP+ + +++I + G +IP GTTL+ + +
Sbjct: 348 GDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIPKGTTLITNLSSVLKD 405
Query: 460 PDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNF 518
V+ P +F P++FL + AF+PFSAG R+C+G A ++L + +++L++F
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>AM183949-1|CAJ75803.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 85.8 bits (203), Expect = 4e-16
Identities = 66/203 (32%), Positives = 99/203 (48%), Gaps = 13/203 (6%)
Query: 354 IMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGD--SDRPVTFQDTLEMKYLER 411
++ G +TTA S+ + + H +IQ ++ EELD G S V ++D + L
Sbjct: 288 LLIGGTETTANTLSWAVVFLFHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNA 347
Query: 412 CLMETLRLYPPVPIIARQVNQEITLPSN--GKKIPAGTTLVIATYKLHRRPDVYPNPNKF 469
+ E LRL P VP+ + T PS+ G IP GT ++ H V+ P++F
Sbjct: 348 TIAEVLRLRPVVPLA---LPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEF 404
Query: 470 DPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVI--SDLKES 527
PD FL E N A F G R C+G A L+L V+L+ +L+ F ++ D S
Sbjct: 405 WPDRFL-EPGKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPS 460
Query: 528 DFKLQADIILKRAEGFQVRLQPR 550
L ++ + + FQVRLQPR
Sbjct: 461 LQPLPHCSVILKMQPFQVRLQPR 483
>S46963-1|AAB23864.2| 477|Homo sapiens cytochrome P-450 protein.
Length = 477
Score = 85.4 bits (202), Expect = 5e-16
Identities = 57/180 (31%), Positives = 92/180 (51%), Gaps = 6/180 (3%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
E ++ + G +TT+ + L ++ H ++ KV EE++++ G + P QD
Sbjct: 272 ESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPC-MQDRS 330
Query: 405 EMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIA-TYKLHRRPDV 462
M Y + + E R +P + V +I IP GTT++I+ T LH +
Sbjct: 331 HMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKF--RNYLIPKGTTILISLTSVLHDNKE- 387
Query: 463 YPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVIS 522
+PNP FDP +FL E + F+PFSAG R CVG A ++L + L++IL+NF + S
Sbjct: 388 FPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKS 447
>M28548-1|AAA52065.1| 495|Homo sapiens protein ( Human mutant
21-hydroxylase B gene, complete cds. ).
Length = 495
Score = 85.4 bits (202), Expect = 5e-16
Identities = 66/203 (32%), Positives = 99/203 (48%), Gaps = 13/203 (6%)
Query: 354 IMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGD--SDRPVTFQDTLEMKYLER 411
++ G +TTA S+ + + H +IQ ++ EELD G S V ++D + L
Sbjct: 289 LLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNA 348
Query: 412 CLMETLRLYPPVPIIARQVNQEITLPSN--GKKIPAGTTLVIATYKLHRRPDVYPNPNKF 469
+ E LRL P VP+ + T PS+ G IP GT ++ H V+ P++F
Sbjct: 349 TIAEVLRLRPVVPLA---LPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEF 405
Query: 470 DPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVI--SDLKES 527
PD FL E N A F G R C+G A L+L V+L+ +L+ F ++ D S
Sbjct: 406 WPDRFL-EPGKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPS 461
Query: 528 DFKLQADIILKRAEGFQVRLQPR 550
L ++ + + FQVRLQPR
Sbjct: 462 LQPLPHCSVILKMQPFQVRLQPR 484
>M26856-1|AAA52064.1| 495|Homo sapiens protein ( Human
21-hydroxylase B gene, complete cds. ).
Length = 495
Score = 85.4 bits (202), Expect = 5e-16
Identities = 66/203 (32%), Positives = 99/203 (48%), Gaps = 13/203 (6%)
Query: 354 IMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGD--SDRPVTFQDTLEMKYLER 411
++ G +TTA S+ + + H +IQ ++ EELD G S V ++D + L
Sbjct: 289 LLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNA 348
Query: 412 CLMETLRLYPPVPIIARQVNQEITLPSN--GKKIPAGTTLVIATYKLHRRPDVYPNPNKF 469
+ E LRL P VP+ + T PS+ G IP GT ++ H V+ P++F
Sbjct: 349 TIAEVLRLRPVVPLA---LPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEF 405
Query: 470 DPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVI--SDLKES 527
PD FL E N A F G R C+G A L+L V+L+ +L+ F ++ D S
Sbjct: 406 WPDRFL-EPGKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPS 461
Query: 528 DFKLQADIILKRAEGFQVRLQPR 550
L ++ + + FQVRLQPR
Sbjct: 462 LQPLPHCSVILKMQPFQVRLQPR 484
>M21940-1|AAA52159.1| 383|Homo sapiens CYP2C protein.
Length = 383
Score = 85.4 bits (202), Expect = 5e-16
Identities = 57/180 (31%), Positives = 92/180 (51%), Gaps = 6/180 (3%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
E ++ + G +TT+ + L ++ H ++ KV EE++++ G + P QD
Sbjct: 178 ESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPC-MQDRS 236
Query: 405 EMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIA-TYKLHRRPDV 462
M Y + + E R +P + V +I IP GTT++I+ T LH +
Sbjct: 237 HMPYTDAVVHEVQRCIDLLPTSLPHAVTCDIKF--RNYLIPKGTTILISLTSVLHDNKE- 293
Query: 463 YPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVIS 522
+PNP FDP +FL E + F+PFSAG R CVG A ++L + L++IL+NF + S
Sbjct: 294 FPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKS 353
>M21939-1|AAA52158.1| 485|Homo sapiens CYP2C protein.
Length = 485
Score = 85.4 bits (202), Expect = 5e-16
Identities = 57/180 (31%), Positives = 92/180 (51%), Gaps = 6/180 (3%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
E ++ + G +TT+ + L ++ H ++ KV EE++++ G + P QD
Sbjct: 280 ESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPC-MQDRS 338
Query: 405 EMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIA-TYKLHRRPDV 462
M Y + + E R +P + V +I IP GTT++I+ T LH +
Sbjct: 339 HMPYTDAVVHEVQRCIDLLPTSLPHAVTCDIKF--RNYLIPKGTTILISLTSVLHDNKE- 395
Query: 463 YPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVIS 522
+PNP FDP +FL E + F+PFSAG R CVG A ++L + L++IL+NF + S
Sbjct: 396 FPNPEMFDPHHFLDEGDNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKS 455
>M21550-1|AAA52063.1| 495|Homo sapiens CYP21 protein.
Length = 495
Score = 85.4 bits (202), Expect = 5e-16
Identities = 66/203 (32%), Positives = 99/203 (48%), Gaps = 13/203 (6%)
Query: 354 IMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGD--SDRPVTFQDTLEMKYLER 411
++ G +TTA S+ + + H +IQ ++ EELD G S V ++D + L
Sbjct: 289 LLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNA 348
Query: 412 CLMETLRLYPPVPIIARQVNQEITLPSN--GKKIPAGTTLVIATYKLHRRPDVYPNPNKF 469
+ E LRL P VP+ + T PS+ G IP GT ++ H V+ P++F
Sbjct: 349 TIAEVLRLRPVVPLA---LPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEF 405
Query: 470 DPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVI--SDLKES 527
PD FL E N A F G R C+G A L+L V+L+ +L+ F ++ D S
Sbjct: 406 WPDRFL-EPGKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPS 461
Query: 528 DFKLQADIILKRAEGFQVRLQPR 550
L ++ + + FQVRLQPR
Sbjct: 462 LQPLPHCSVILKMQPFQVRLQPR 484
>M15331-1|AAA52157.1| 485|Homo sapiens CYP2C protein.
Length = 485
Score = 85.4 bits (202), Expect = 5e-16
Identities = 57/180 (31%), Positives = 92/180 (51%), Gaps = 6/180 (3%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
E ++ + G +TT+ + L ++ H ++ KV EE++++ G + P QD
Sbjct: 280 ESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPC-MQDRS 338
Query: 405 EMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIA-TYKLHRRPDV 462
M Y + + E R +P + V +I IP GTT++I+ T LH +
Sbjct: 339 HMPYTDAVVHEVQRCIDLLPTSLPHAVTCDIKF--RNYLIPKGTTILISLTSVLHDNKE- 395
Query: 463 YPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVIS 522
+PNP FDP +FL E + F+PFSAG R CVG A ++L + L++IL+NF + S
Sbjct: 396 FPNPEMFDPHHFLDEGDNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKS 455
>M13936-1|AAA59695.1| 494|Homo sapiens CYP21P protein.
Length = 494
Score = 85.4 bits (202), Expect = 5e-16
Identities = 66/203 (32%), Positives = 99/203 (48%), Gaps = 13/203 (6%)
Query: 354 IMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGD--SDRPVTFQDTLEMKYLER 411
++ G +TTA S+ + + H +IQ ++ EELD G S V ++D + L
Sbjct: 288 LLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNA 347
Query: 412 CLMETLRLYPPVPIIARQVNQEITLPSN--GKKIPAGTTLVIATYKLHRRPDVYPNPNKF 469
+ E LRL P VP+ + T PS+ G IP GT ++ H V+ P++F
Sbjct: 348 TIAEVLRLRPVVPLA---LPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEF 404
Query: 470 DPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVI--SDLKES 527
PD FL E N A F G R C+G A L+L V+L+ +L+ F ++ D S
Sbjct: 405 WPDRFL-EPGKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPS 460
Query: 528 DFKLQADIILKRAEGFQVRLQPR 550
L ++ + + FQVRLQPR
Sbjct: 461 LQPLPHCSVILKMQPFQVRLQPR 483
>D00173-1|BAA00123.1| 487|Homo sapiens cytochrome P-450 protein.
Length = 487
Score = 85.4 bits (202), Expect = 5e-16
Identities = 57/180 (31%), Positives = 92/180 (51%), Gaps = 6/180 (3%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
E ++ + G +TT+ + L ++ H ++ KV EE++++ G + P QD
Sbjct: 282 ESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPC-MQDRS 340
Query: 405 EMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIA-TYKLHRRPDV 462
M Y + + E R +P + V +I IP GTT++I+ T LH +
Sbjct: 341 HMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKF--RNYLIPKGTTILISLTSVLHDNKE- 397
Query: 463 YPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVIS 522
+PNP FDP +FL E + F+PFSAG R CVG A ++L + L++IL+NF + S
Sbjct: 398 FPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKS 457
>BX679671-8|CAM26071.1| 464|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 464
Score = 85.4 bits (202), Expect = 5e-16
Identities = 66/203 (32%), Positives = 99/203 (48%), Gaps = 13/203 (6%)
Query: 354 IMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGD--SDRPVTFQDTLEMKYLER 411
++ G +TTA S+ + + H +IQ ++ EELD G S V ++D + L
Sbjct: 258 LLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNA 317
Query: 412 CLMETLRLYPPVPIIARQVNQEITLPSN--GKKIPAGTTLVIATYKLHRRPDVYPNPNKF 469
+ E LRL P VP+ + T PS+ G IP GT ++ H V+ P++F
Sbjct: 318 TIAEVLRLRPVVPLA---LPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEF 374
Query: 470 DPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVI--SDLKES 527
PD FL E N A F G R C+G A L+L V+L+ +L+ F ++ D S
Sbjct: 375 WPDRFL-EPGKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPS 430
Query: 528 DFKLQADIILKRAEGFQVRLQPR 550
L ++ + + FQVRLQPR
Sbjct: 431 LQPLPHCSVILKMQPFQVRLQPR 453
>BX679671-7|CAM26070.1| 494|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 494
Score = 85.4 bits (202), Expect = 5e-16
Identities = 66/203 (32%), Positives = 99/203 (48%), Gaps = 13/203 (6%)
Query: 354 IMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGD--SDRPVTFQDTLEMKYLER 411
++ G +TTA S+ + + H +IQ ++ EELD G S V ++D + L
Sbjct: 288 LLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNA 347
Query: 412 CLMETLRLYPPVPIIARQVNQEITLPSN--GKKIPAGTTLVIATYKLHRRPDVYPNPNKF 469
+ E LRL P VP+ + T PS+ G IP GT ++ H V+ P++F
Sbjct: 348 TIAEVLRLRPVVPLA---LPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEF 404
Query: 470 DPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVI--SDLKES 527
PD FL E N A F G R C+G A L+L V+L+ +L+ F ++ D S
Sbjct: 405 WPDRFL-EPGKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPS 460
Query: 528 DFKLQADIILKRAEGFQVRLQPR 550
L ++ + + FQVRLQPR
Sbjct: 461 LQPLPHCSVILKMQPFQVRLQPR 483
>BC125182-1|AAI25183.1| 494|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 494
Score = 85.4 bits (202), Expect = 5e-16
Identities = 66/203 (32%), Positives = 99/203 (48%), Gaps = 13/203 (6%)
Query: 354 IMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGD--SDRPVTFQDTLEMKYLER 411
++ G +TTA S+ + + H +IQ ++ EELD G S V ++D + L
Sbjct: 288 LLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNA 347
Query: 412 CLMETLRLYPPVPIIARQVNQEITLPSN--GKKIPAGTTLVIATYKLHRRPDVYPNPNKF 469
+ E LRL P VP+ + T PS+ G IP GT ++ H V+ P++F
Sbjct: 348 TIAEVLRLRPVVPLA---LPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEF 404
Query: 470 DPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVI--SDLKES 527
PD FL E N A F G R C+G A L+L V+L+ +L+ F ++ D S
Sbjct: 405 WPDRFL-EPGKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPS 460
Query: 528 DFKLQADIILKRAEGFQVRLQPR 550
L ++ + + FQVRLQPR
Sbjct: 461 LQPLPHCSVILKMQPFQVRLQPR 483
>BC125181-1|AAI25182.1| 495|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 495
Score = 85.4 bits (202), Expect = 5e-16
Identities = 66/203 (32%), Positives = 99/203 (48%), Gaps = 13/203 (6%)
Query: 354 IMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGD--SDRPVTFQDTLEMKYLER 411
++ G +TTA S+ + + H +IQ ++ EELD G S V ++D + L
Sbjct: 289 LLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNA 348
Query: 412 CLMETLRLYPPVPIIARQVNQEITLPSN--GKKIPAGTTLVIATYKLHRRPDVYPNPNKF 469
+ E LRL P VP+ + T PS+ G IP GT ++ H V+ P++F
Sbjct: 349 TIAEVLRLRPVVPLA---LPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEF 405
Query: 470 DPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVI--SDLKES 527
PD FL E N A F G R C+G A L+L V+L+ +L+ F ++ D S
Sbjct: 406 WPDRFL-EPGKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPS 461
Query: 528 DFKLQADIILKRAEGFQVRLQPR 550
L ++ + + FQVRLQPR
Sbjct: 462 LQPLPHCSVILKMQPFQVRLQPR 484
>BC125054-1|AAI25055.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 85.4 bits (202), Expect = 5e-16
Identities = 57/180 (31%), Positives = 92/180 (51%), Gaps = 6/180 (3%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
E ++ + G +TT+ + L ++ H ++ KV EE++++ G + P QD
Sbjct: 285 ESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPC-MQDRS 343
Query: 405 EMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIA-TYKLHRRPDV 462
M Y + + E R +P + V +I IP GTT++I+ T LH +
Sbjct: 344 HMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKF--RNYLIPKGTTILISLTSVLHDNKE- 400
Query: 463 YPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVIS 522
+PNP FDP +FL E + F+PFSAG R CVG A ++L + L++IL+NF + S
Sbjct: 401 FPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKS 460
>AY702706-1|AAT94065.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 85.4 bits (202), Expect = 5e-16
Identities = 57/180 (31%), Positives = 92/180 (51%), Gaps = 6/180 (3%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
E ++ + G +TT+ + L ++ H ++ KV EE++++ G + P QD
Sbjct: 285 ESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPC-MQDRS 343
Query: 405 EMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIA-TYKLHRRPDV 462
M Y + + E R +P + V +I IP GTT++I+ T LH +
Sbjct: 344 HMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKF--RNYLIPKGTTILISLTSVLHDNKE- 400
Query: 463 YPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVIS 522
+PNP FDP +FL E + F+PFSAG R CVG A ++L + L++IL+NF + S
Sbjct: 401 FPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKS 460
>AY341248-1|AAP88931.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 85.4 bits (202), Expect = 5e-16
Identities = 57/180 (31%), Positives = 92/180 (51%), Gaps = 6/180 (3%)
Query: 345 EEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTL 404
E ++ + G +TT+ + L ++ H ++ KV EE++++ G + P QD
Sbjct: 285 ESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPC-MQDRS 343
Query: 405 EMKYLERCLMETLRLYPPVPI-IARQVNQEITLPSNGKKIPAGTTLVIA-TYKLHRRPDV 462
M Y + + E R +P + V +I IP GTT++I+ T LH +
Sbjct: 344 HMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKF--RNYLIPKGTTILISLTSVLHDNKE- 400
Query: 463 YPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVIS 522
+PNP FDP +FL E + F+PFSAG R CVG A ++L + L++IL+NF + S
Sbjct: 401 FPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKS 460
>AM183951-1|CAJ75805.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 85.4 bits (202), Expect = 5e-16
Identities = 66/203 (32%), Positives = 99/203 (48%), Gaps = 13/203 (6%)
Query: 354 IMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGD--SDRPVTFQDTLEMKYLER 411
++ G +TTA S+ + + H +IQ ++ EELD G S V ++D + L
Sbjct: 288 LLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNA 347
Query: 412 CLMETLRLYPPVPIIARQVNQEITLPSN--GKKIPAGTTLVIATYKLHRRPDVYPNPNKF 469
+ E LRL P VP+ + T PS+ G IP GT ++ H V+ P++F
Sbjct: 348 TIAEVLRLRPVVPLA---LPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEF 404
Query: 470 DPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVI--SDLKES 527
PD FL E N A F G R C+G A L+L V+L+ +L+ F ++ D S
Sbjct: 405 WPDRFL-EPGKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPS 460
Query: 528 DFKLQADIILKRAEGFQVRLQPR 550
L ++ + + FQVRLQPR
Sbjct: 461 LQPLPHCSVILKIQPFQVRLQPR 483
>AM183947-1|CAJ75801.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 85.4 bits (202), Expect = 5e-16
Identities = 66/203 (32%), Positives = 99/203 (48%), Gaps = 13/203 (6%)
Query: 354 IMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGD--SDRPVTFQDTLEMKYLER 411
++ G +TTA S+ + + H +IQ ++ EELD G S V ++D + L
Sbjct: 288 LLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNA 347
Query: 412 CLMETLRLYPPVPIIARQVNQEITLPSN--GKKIPAGTTLVIATYKLHRRPDVYPNPNKF 469
+ E LRL P VP+ + T PS+ G IP GT ++ H V+ P++F
Sbjct: 348 TIAEVLRLRPVVPLA---LPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEF 404
Query: 470 DPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVI--SDLKES 527
PD FL E N A F G R C+G A L+L V+L+ +L+ F ++ D S
Sbjct: 405 WPDRFL-EPGKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPS 460
Query: 528 DFKLQADIILKRAEGFQVRLQPR 550
L ++ + + FQVRLQPR
Sbjct: 461 LQPLPHCSVILKMQPFQVRLQPR 483
>AM183946-1|CAJ75800.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 85.4 bits (202), Expect = 5e-16
Identities = 66/203 (32%), Positives = 99/203 (48%), Gaps = 13/203 (6%)
Query: 354 IMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGD--SDRPVTFQDTLEMKYLER 411
++ G +TTA S+ + + H +IQ ++ EELD G S V ++D + L
Sbjct: 288 LLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNA 347
Query: 412 CLMETLRLYPPVPIIARQVNQEITLPSN--GKKIPAGTTLVIATYKLHRRPDVYPNPNKF 469
+ E LRL P VP+ + T PS+ G IP GT ++ H V+ P++F
Sbjct: 348 TIAEVLRLRPVVPLA---LPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEF 404
Query: 470 DPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVI--SDLKES 527
PD FL E N A F G R C+G A L+L V+L+ +L+ F ++ D S
Sbjct: 405 WPDRFL-EPGKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPS 460
Query: 528 DFKLQADIILKRAEGFQVRLQPR 550
L ++ + + FQVRLQPR
Sbjct: 461 LQPLPHCSVILKMQPFQVRLQPR 483
>AM183945-1|CAJ75799.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 85.4 bits (202), Expect = 5e-16
Identities = 66/203 (32%), Positives = 99/203 (48%), Gaps = 13/203 (6%)
Query: 354 IMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGD--SDRPVTFQDTLEMKYLER 411
++ G +TTA S+ + + H +IQ ++ EELD G S V ++D + L
Sbjct: 288 LLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNA 347
Query: 412 CLMETLRLYPPVPIIARQVNQEITLPSN--GKKIPAGTTLVIATYKLHRRPDVYPNPNKF 469
+ E LRL P VP+ + T PS+ G IP GT ++ H V+ P++F
Sbjct: 348 TIAEVLRLRPVVPLA---LPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEF 404
Query: 470 DPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVI--SDLKES 527
PD FL E N A F G R C+G A L+L V+L+ +L+ F ++ D S
Sbjct: 405 WPDRFL-EPGKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPS 460
Query: 528 DFKLQADIILKRAEGFQVRLQPR 550
L ++ + + FQVRLQPR
Sbjct: 461 LQPLPHCSVILKMQPFQVRLQPR 483
>AM086565-1|CAJ31104.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 85.4 bits (202), Expect = 5e-16
Identities = 66/203 (32%), Positives = 99/203 (48%), Gaps = 13/203 (6%)
Query: 354 IMFEGHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGD--SDRPVTFQDTLEMKYLER 411
++ G +TTA S+ + + H +IQ ++ EELD G S V ++D + L
Sbjct: 288 LLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNA 347
Query: 412 CLMETLRLYPPVPIIARQVNQEITLPSN--GKKIPAGTTLVIATYKLHRRPDVYPNPNKF 469
+ E LRL P VP+ + T PS+ G IP GT ++ H V+ P++F
Sbjct: 348 TIAEVLRLRPVVPLA---LPHRTTRPSSISGYDIPEGTVIIPNLQGTHLDETVWERPHEF 404
Query: 470 DPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKVILSTILRNFRVI--SDLKES 527
PD FL E N A F G R C+G A L+L V+L+ +L+ F ++ D S
Sbjct: 405 WPDRFL-EPGKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPS 460
Query: 528 DFKLQADIILKRAEGFQVRLQPR 550
L ++ + + FQVRLQPR
Sbjct: 461 LQPLPHCSVILKMQPFQVRLQPR 483
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.321 0.136 0.397
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 74,480,566
Number of Sequences: 224733
Number of extensions: 2950773
Number of successful extensions: 6906
Number of sequences better than 10.0: 458
Number of HSP's better than 10.0 without gapping: 384
Number of HSP's successfully gapped in prelim test: 74
Number of HSP's that attempted gapping in prelim test: 5543
Number of HSP's gapped (non-prelim): 662
length of query: 556
length of database: 73,234,838
effective HSP length: 94
effective length of query: 462
effective length of database: 52,109,936
effective search space: 24074790432
effective search space used: 24074790432
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.9 bits)
S2: 68 (31.5 bits)
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