Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001156-TA|BGIBMGA001156-PA|IPR010097|Malate
dehydrogenase, NAD-dependent, eukaryotes and gamma proteobacteria,
IPR001236|Lactate/malate dehydrogenase
(344 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P40926 Cluster: Malate dehydrogenase, mitochondrial pre... 206 9e-52
UniRef50_P08249 Cluster: Malate dehydrogenase, mitochondrial pre... 204 3e-51
UniRef50_Q9VU28 Cluster: Malate dehydrogenase; n=3; Sophophora|R... 199 1e-49
UniRef50_Q42972 Cluster: Malate dehydrogenase, glyoxysomal precu... 199 1e-49
UniRef50_Q9VU29 Cluster: Malate dehydrogenase; n=5; Protostomia|... 198 2e-49
UniRef50_Q9SN86 Cluster: Malate dehydrogenase, chloroplast precu... 187 4e-46
UniRef50_UPI0000D571DB Cluster: PREDICTED: similar to CG7998-PA;... 178 1e-43
UniRef50_Q4Q3J3 Cluster: Malate dehydrogenase, putative; n=3; Le... 178 1e-43
UniRef50_A2QMH9 Cluster: Malate dehydrogenase; n=7; Fungi/Metazo... 167 4e-40
UniRef50_Q9Y7R8 Cluster: Malate dehydrogenase; n=13; Dikarya|Rep... 157 4e-37
UniRef50_Q86DP2 Cluster: Malate dehydrogenase; n=11; Fungi/Metaz... 143 7e-33
UniRef50_Q6BM17 Cluster: Malate dehydrogenase; n=4; Eukaryota|Re... 141 2e-32
UniRef50_Q4QDF0 Cluster: Glycosomal malate dehydrogenase; n=9; T... 138 1e-31
UniRef50_UPI0000DB76D8 Cluster: PREDICTED: similar to CG7998-PA;... 137 3e-31
UniRef50_Q5ENS5 Cluster: Malate dehydrogenase; n=1; Heterocapsa ... 135 2e-30
UniRef50_Q017A6 Cluster: Malate dehydrogenase; n=2; cellular org... 130 4e-29
UniRef50_A7TL95 Cluster: Putative uncharacterized protein; n=1; ... 126 8e-28
UniRef50_A7SQS1 Cluster: Predicted protein; n=1; Nematostella ve... 125 2e-27
UniRef50_P32419 Cluster: Malate dehydrogenase, peroxisomal; n=24... 122 2e-26
UniRef50_Q6CP51 Cluster: Similar to sp|P22133 Saccharomyces cere... 121 2e-26
UniRef50_Q75AT4 Cluster: ADL164Cp; n=2; Saccharomycetales|Rep: A... 121 3e-26
UniRef50_P22133 Cluster: Malate dehydrogenase, cytoplasmic; n=3;... 118 2e-25
UniRef50_Q6FL22 Cluster: Malate dehydrogenase; n=1; Candida glab... 116 7e-25
UniRef50_UPI0000D55CD8 Cluster: PREDICTED: similar to Malate DeH... 115 2e-24
UniRef50_A7TSF5 Cluster: Putative uncharacterized protein; n=1; ... 113 5e-24
UniRef50_Q4Q3J5 Cluster: Malate dehydrogenase, putative; n=5; Tr... 103 9e-21
UniRef50_A3BMG8 Cluster: Putative uncharacterized protein; n=3; ... 92 2e-17
UniRef50_UPI00015B5ACF Cluster: PREDICTED: similar to ENSANGP000... 89 1e-16
UniRef50_A2SSY4 Cluster: L-lactate dehydrogenase; n=3; Methanomi... 85 2e-15
UniRef50_UPI00015B4591 Cluster: PREDICTED: similar to mitochondr... 84 4e-15
UniRef50_A7I5J9 Cluster: L-lactate dehydrogenase precursor; n=1;... 84 4e-15
UniRef50_UPI0000DB6C4F Cluster: PREDICTED: similar to Malate DeH... 84 6e-15
UniRef50_A7I2F1 Cluster: Malate dehydrogenase; n=1; Campylobacte... 82 2e-14
UniRef50_Q7M9A7 Cluster: Malate dehydrogenase; n=4; Epsilonprote... 81 3e-14
UniRef50_Q979N9 Cluster: Malate dehydrogenase; n=4; Thermoplasma... 81 4e-14
UniRef50_Q3J7E7 Cluster: Malate dehydrogenase; n=5; Gammaproteob... 81 4e-14
UniRef50_A7GYI6 Cluster: Lactate/malate dehydrogenase, NAD bindi... 80 7e-14
UniRef50_O26290 Cluster: Malate dehydrogenase; n=2; Methanobacte... 80 7e-14
UniRef50_Q64P62 Cluster: Malate dehydrogenase; n=28; Bacteroidet... 80 7e-14
UniRef50_Q8TWG5 Cluster: Malate dehydrogenase; n=2; Euryarchaeot... 80 1e-13
UniRef50_Q6VVP7 Cluster: Malate dehydrogenase; n=6; Plasmodium|R... 78 3e-13
UniRef50_UPI0000D56DC5 Cluster: PREDICTED: similar to Malate deh... 77 5e-13
UniRef50_P16115 Cluster: L-lactate dehydrogenase; n=4; Thermotog... 77 5e-13
UniRef50_A3EWH3 Cluster: Malate/lactate dehydrogenase; n=1; Lept... 76 2e-12
UniRef50_Q7NHJ3 Cluster: Malate dehydrogenase; n=13; cellular or... 76 2e-12
UniRef50_O67655 Cluster: Malate dehydrogenase 1; n=3; Bacteria|R... 75 3e-12
UniRef50_P22988 Cluster: L-lactate dehydrogenase A; n=19; Magnol... 74 5e-12
UniRef50_UPI00005A0834 Cluster: PREDICTED: similar to Malate deh... 73 1e-11
UniRef50_Q86S07 Cluster: NAD-specific malate dehydrogenase 2; n=... 73 1e-11
UniRef50_A6Q7S2 Cluster: Malate dehydrogenase, NAD-dependent; n=... 73 1e-11
UniRef50_Q7VFV4 Cluster: Malate dehydrogenase; n=1; Helicobacter... 72 2e-11
UniRef50_A4A2L6 Cluster: L-lactate dehydrogenase; n=4; Bacteria|... 71 3e-11
UniRef50_A7U552 Cluster: Mitochondrial malate-dehydrogenase; n=2... 71 3e-11
UniRef50_Q18WQ6 Cluster: Malate dehydrogenase, NAD-dependent; n=... 71 4e-11
UniRef50_A0RXX8 Cluster: Malate/L-lactate dehydrogenase; n=1; Ce... 70 1e-10
UniRef50_A7DRG3 Cluster: Lactate/malate dehydrogenase; n=1; Cand... 69 1e-10
UniRef50_Q8YJE7 Cluster: Malate dehydrogenase; n=98; Bacteria|Re... 69 1e-10
UniRef50_Q5CYZ2 Cluster: Lactate dehydrogenase, adjacent gene en... 69 2e-10
UniRef50_Q6LZI3 Cluster: Malate dehydrogenase; n=5; Methanococcu... 68 4e-10
UniRef50_A1U9V0 Cluster: Lactate/malate dehydrogenase; n=6; Acti... 67 7e-10
UniRef50_Q9PHY2 Cluster: Probable malate dehydrogenase; n=12; Ca... 67 7e-10
UniRef50_Q8ZVB2 Cluster: Malate dehydrogenase; n=14; Thermoprote... 66 1e-09
UniRef50_P59390 Cluster: L-lactate dehydrogenase 2; n=8; Lactoba... 66 1e-09
UniRef50_A4L2P0 Cluster: L-lactate dehydrogenase; n=4; Lactobaci... 65 3e-09
UniRef50_Q5LXE1 Cluster: Malate dehydrogenase; n=115; cellular o... 64 5e-09
UniRef50_Q892U0 Cluster: L-lactate dehydrogenase; n=12; Bacteria... 63 9e-09
UniRef50_Q07841 Cluster: Malate dehydrogenase; n=7; Halobacteria... 62 2e-08
UniRef50_Q1IRL5 Cluster: L-lactate dehydrogenase; n=6; Bacteria|... 62 2e-08
UniRef50_Q3ZZJ7 Cluster: Malate dehydrogenase; n=5; cellular org... 62 2e-08
UniRef50_A5KJY5 Cluster: Putative uncharacterized protein; n=2; ... 62 3e-08
UniRef50_P11386 Cluster: Malate dehydrogenase; n=6; Sulfolobacea... 62 3e-08
UniRef50_Q8XP62 Cluster: L-lactate dehydrogenase; n=11; Clostrid... 62 3e-08
UniRef50_O67581 Cluster: Malate dehydrogenase 2; n=1; Aquifex ae... 60 6e-08
UniRef50_Q9P7P7 Cluster: Probable L-lactate dehydrogenase; n=2; ... 60 6e-08
UniRef50_Q4Q7X6 Cluster: Cytosolic malate dehydrogenase, putativ... 60 1e-07
UniRef50_Q6A9C3 Cluster: L-lactate dehydrogenase; n=2; Propionib... 60 1e-07
UniRef50_A1HSK3 Cluster: Lactate/malate dehydrogenase; n=1; Ther... 59 1e-07
UniRef50_Q7UY63 Cluster: L-lactate/malate dehydrogenase; n=2; Pl... 59 2e-07
UniRef50_P0A3M9 Cluster: L-lactate dehydrogenase; n=140; Bacteri... 59 2e-07
UniRef50_O51114 Cluster: L-lactate dehydrogenase; n=4; Borrelia ... 59 2e-07
UniRef50_Q6KIP9 Cluster: L-lactate dehydrogenase; n=1; Mycoplasm... 58 3e-07
UniRef50_A0C8S6 Cluster: Malate dehydrogenase; n=3; Paramecium t... 58 3e-07
UniRef50_Q81K80 Cluster: L-lactate dehydrogenase 2; n=12; Firmic... 58 4e-07
UniRef50_Q8IE66 Cluster: Oxidoreductase, putative; n=6; Plasmodi... 57 8e-07
UniRef50_P62056 Cluster: L-lactate dehydrogenase; n=2; Bacteria|... 56 1e-06
UniRef50_Q6F0L9 Cluster: L-lactate dehydrogenase; n=6; Mollicute... 56 1e-06
UniRef50_Q98PG4 Cluster: L-lactate dehydrogenase; n=1; Mycoplasm... 56 1e-06
UniRef50_A0LRV1 Cluster: Lactate/malate dehydrogenase; n=3; Acti... 55 2e-06
UniRef50_Q86S08 Cluster: NAD-specific malate dehydrogenase 1; n=... 55 2e-06
UniRef50_Q03BE6 Cluster: L-lactate dehydrogenase; n=1; Lactobaci... 55 3e-06
UniRef50_A2SNY0 Cluster: Malate/lactate dehydrogenases-like prot... 55 3e-06
UniRef50_Q838C9 Cluster: L-lactate dehydrogenase 2; n=9; Bacilli... 54 4e-06
UniRef50_P19869 Cluster: L-lactate dehydrogenase 2; n=17; Bacter... 54 4e-06
UniRef50_Q87JV1 Cluster: Lactate dehydrogenase; n=4; Vibrio|Rep:... 54 5e-06
UniRef50_A6M0Q2 Cluster: L-lactate dehydrogenase; n=1; Clostridi... 54 5e-06
UniRef50_Q4A0K7 Cluster: Lactate dehydrogenase; n=1; Staphylococ... 53 1e-05
UniRef50_P20619 Cluster: L-lactate dehydrogenase X; n=14; Bacill... 52 2e-05
UniRef50_Q4SRH5 Cluster: L-lactate dehydrogenase; n=4; Euteleost... 52 3e-05
UniRef50_Q2S4R2 Cluster: L-lactate dehydrogenase; n=1; Salinibac... 52 3e-05
UniRef50_Q7NG49 Cluster: L-lactate dehydrogenase; n=4; Cyanobact... 52 3e-05
UniRef50_Q1FID3 Cluster: L-lactate dehydrogenase precursor; n=1;... 51 4e-05
UniRef50_A5Z9B1 Cluster: Putative uncharacterized protein; n=1; ... 51 4e-05
UniRef50_P47698 Cluster: L-lactate dehydrogenase; n=2; Mycoplasm... 51 4e-05
UniRef50_P0C0J4 Cluster: L-lactate dehydrogenase; n=5; Mycoplasm... 51 5e-05
UniRef50_UPI0000519EC7 Cluster: PREDICTED: similar to Ecdysone-i... 50 7e-05
UniRef50_Q4UJ29 Cluster: L-lactate dehydrogenase, putative; n=2;... 50 9e-05
UniRef50_UPI000023CE12 Cluster: hypothetical protein FG10444.1; ... 50 1e-04
UniRef50_O08349 Cluster: Malate dehydrogenase; n=1; Archaeoglobu... 50 1e-04
UniRef50_Q9P4B6 Cluster: L-lactate dehydrogenase A; n=48; Rhizop... 49 2e-04
UniRef50_UPI000038D9FF Cluster: COG0039: Malate/lactate dehydrog... 49 2e-04
UniRef50_A3DCA4 Cluster: L-lactate dehydrogenase precursor; n=2;... 49 2e-04
UniRef50_Q4L941 Cluster: L-lactate dehydrogenase; n=1; Staphyloc... 49 2e-04
UniRef50_Q64YY6 Cluster: Malate dehydrogenase; n=5; Bacteroidale... 48 3e-04
UniRef50_Q81XJ7 Cluster: L-lactate dehydrogenase 3; n=13; Firmic... 48 3e-04
UniRef50_Q0PQR8 Cluster: Malate dehydrogenase NAD-dependent; n=1... 48 4e-04
UniRef50_Q4D123 Cluster: Malate dehydrogenase; n=9; Eukaryota|Re... 48 4e-04
UniRef50_Q7MTK2 Cluster: Malate dehydrogenase; n=4; Bacteroidale... 48 5e-04
UniRef50_P62051 Cluster: L-lactate dehydrogenase; n=2; Desulfovi... 48 5e-04
UniRef50_UPI00015BB1FC Cluster: malate dehydrogenase (NAD); n=1;... 47 6e-04
UniRef50_Q6A6E3 Cluster: L-lactate dehydrogenase; n=1; Propionib... 47 6e-04
UniRef50_Q92BI0 Cluster: L-lactate dehydrogenase 2; n=18; Bacter... 47 6e-04
UniRef50_A6NLX8 Cluster: L-lactate dehydrogenase; n=4; Eutheria|... 47 8e-04
UniRef50_A2G340 Cluster: Malate dehydrogenase; n=18; Trichomonad... 46 0.001
UniRef50_P50933 Cluster: L-lactate dehydrogenase; n=7; Bacteria|... 46 0.001
UniRef50_Q97DC6 Cluster: L-lactate dehydrogenase 2; n=1; Clostri... 46 0.001
UniRef50_A2Q223 Cluster: Lactate/malate dehydrogenase, alpha/bet... 46 0.001
UniRef50_A2E124 Cluster: Malate dehydrogenase; n=6; Trichomonadi... 46 0.001
UniRef50_Q92AZ3 Cluster: Lin1775 protein; n=13; Listeria|Rep: Li... 46 0.002
UniRef50_Q27743 Cluster: L-lactate dehydrogenase; n=17; Apicompl... 46 0.002
UniRef50_A0BHM8 Cluster: Malate dehydrogenase; n=3; Paramecium t... 45 0.003
UniRef50_Q185V1 Cluster: L-lactate dehydrogenase; n=3; Clostridi... 45 0.003
UniRef50_Q9GSY3 Cluster: Malate dehydrogenase; n=1; Hypotrichomo... 44 0.004
UniRef50_P61973 Cluster: Malate dehydrogenase; n=43; Bacteria|Re... 44 0.004
UniRef50_A3JXA9 Cluster: L-lactate dehydrogenase; n=1; Sagittula... 44 0.006
UniRef50_Q9EVR0 Cluster: L-lactate dehydrogenase; n=1; Selenomon... 44 0.006
UniRef50_A7DSJ4 Cluster: Lactate/malate dehydrogenase; n=1; Cand... 44 0.008
UniRef50_Q8ELF0 Cluster: L-lactate dehydrogenase; n=5; Bacillace... 44 0.008
UniRef50_P07864 Cluster: L-lactate dehydrogenase C chain; n=371;... 44 0.008
UniRef50_A5IYS9 Cluster: L-lactate dehydrogenase; n=2; Mycoplasm... 43 0.010
UniRef50_Q6JH30 Cluster: Lactate dehydrogenase; n=3; Plasmodium ... 43 0.010
UniRef50_Q6NPB9 Cluster: AT22132p; n=2; Drosophila melanogaster|... 43 0.013
UniRef50_Q23CW4 Cluster: Malate dehydrogenase, cytoplasmic, puta... 43 0.013
UniRef50_Q4JY42 Cluster: L-lactate dehydrogenase; n=1; Corynebac... 43 0.013
UniRef50_Q0UX88 Cluster: L-lactate dehydrogenase; n=2; Phaeospha... 42 0.031
UniRef50_A1W9K7 Cluster: Malate dehydrogenase; n=95; cellular or... 42 0.031
UniRef50_O52354 Cluster: L-lactate dehydrogenase; n=1; Mycoplasm... 42 0.031
UniRef50_A3ZZ88 Cluster: L-lactate/malate dehydrogenase; n=1; Bl... 41 0.054
UniRef50_Q4J9W2 Cluster: Putative uncharacterized protein; n=1; ... 41 0.054
UniRef50_A1C5Q5 Cluster: L-lactate dehydrogenase; n=4; Pezizomyc... 40 0.072
UniRef50_Q82R06 Cluster: Putative lactate dehydrogenase; n=1; St... 40 0.13
UniRef50_Q8I8U4 Cluster: Lactate dehydrogenase; n=3; Eimeriorina... 39 0.17
UniRef50_Q9GPV2 Cluster: Cytosolic malate dehydrogenase; n=4; Tr... 39 0.22
UniRef50_Q8I8I5 Cluster: Malate dehydrogenase; n=2; Eukaryota|Re... 38 0.38
UniRef50_Q9Z6N1 Cluster: Malate dehydrogenase; n=8; Chlamydiacea... 38 0.38
UniRef50_Q9UAV5 Cluster: Malate dehydrogenase; n=15; Eukaryota|R... 38 0.50
UniRef50_Q03ZZ4 Cluster: Enzyme with possible activities of L-2-... 37 0.67
UniRef50_A4BB89 Cluster: Lactate dehydrogenase; n=2; Gammaproteo... 37 0.88
UniRef50_Q22N17 Cluster: Putative uncharacterized protein; n=1; ... 35 2.7
UniRef50_Q0P989 Cluster: L-lactate dehydrogenase; n=10; Campylob... 35 3.6
UniRef50_Q2U1D9 Cluster: Predicted protein; n=1; Aspergillus ory... 34 4.7
UniRef50_A1ZW20 Cluster: Putative uncharacterized protein; n=1; ... 34 6.2
UniRef50_P15719 Cluster: Malate dehydrogenase [NADP], chloroplas... 34 6.2
>UniRef50_P40926 Cluster: Malate dehydrogenase, mitochondrial
precursor; n=119; cellular organisms|Rep: Malate
dehydrogenase, mitochondrial precursor - Homo sapiens
(Human)
Length = 338
Score = 206 bits (502), Expect = 9e-52
Identities = 114/328 (34%), Positives = 185/328 (56%), Gaps = 3/328 (0%)
Query: 14 LKKNTLILQKRNVQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELSNL 73
L+++ + N +V+V+GA+ IG +SL LK + VS+L LYD G +LS++
Sbjct: 13 LRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIA-HTPGVAADLSHI 71
Query: 74 PGGPSVSAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQ 133
+V ++G L + ++VV+ + +PRKPG TR+ + NA ++ L A A
Sbjct: 72 ETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQH 131
Query: 134 NQEAFVAISTNPINYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQE 193
EA + + NP+N IP + V K+G YNP+K+FG+T +D R+ +FVA+ ++
Sbjct: 132 CPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPAR 191
Query: 194 IQVPVIGGHSDKTIIPLFSNLTPRNYRIEPCQADMLTRLVRKAGTEVVMHKHGAESSTLA 253
+ VPVIGGH+ KTIIPL S TP+ Q LT +++AGTEVV K GA S+TL+
Sbjct: 192 VNVPVIGGHAGKTIIPLISQCTPK-VDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLS 250
Query: 254 MAWSINEFIDIILDAILGYRVVVNC-YTANSNFGTKFFAGPTSVGPHGIIQACCHFPMSE 312
MA++ F+ ++DA+ G VV C + + +F+ P +G GI + +S
Sbjct: 251 MAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSS 310
Query: 313 FESYLLNRCIPILSREVLEGEKYVEFME 340
FE +++ IP L + +GE +V+ ++
Sbjct: 311 FEEKMISDAIPELKASIKKGEDFVKTLK 338
>UniRef50_P08249 Cluster: Malate dehydrogenase, mitochondrial
precursor; n=514; cellular organisms|Rep: Malate
dehydrogenase, mitochondrial precursor - Mus musculus
(Mouse)
Length = 338
Score = 204 bits (498), Expect = 3e-51
Identities = 115/328 (35%), Positives = 184/328 (56%), Gaps = 3/328 (0%)
Query: 14 LKKNTLILQKRNVQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELSNL 73
L+++ + N +V+V+GA+ IG +SL LK + VS+L LYD G +LS++
Sbjct: 13 LRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIA-HTPGVAADLSHI 71
Query: 74 PGGPSVSAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQ 133
+V ++G L + ++VV+ + +PRKPG TR+ + NA ++ L A A
Sbjct: 72 ETRANVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQH 131
Query: 134 NQEAFVAISTNPINYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQE 193
EA V I NP+N IP + V K+G YNP+K+FG+T +D R+ +FVA+ ++
Sbjct: 132 CPEAMVCIIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPAR 191
Query: 194 IQVPVIGGHSDKTIIPLFSNLTPRNYRIEPCQADMLTRLVRKAGTEVVMHKHGAESSTLA 253
+ VPVIGGH+ KTIIPL S TP+ Q LT +++AGTEVV K GA S+TL+
Sbjct: 192 VNVPVIGGHAGKTIIPLISQCTPK-VDFPQDQLATLTGRIQEAGTEVVKAKAGAGSATLS 250
Query: 254 MAWSINEFIDIILDAILGYRVVVNC-YTANSNFGTKFFAGPTSVGPHGIIQACCHFPMSE 312
MA++ F+ ++DA+ G VV C + + +F+ P +G G+ + ++
Sbjct: 251 MAYAGARFVFSLVDAMNGKEGVVECSFVQSKETECTYFSTPLLLGKKGLEKNLGIGKITP 310
Query: 313 FESYLLNRCIPILSREVLEGEKYVEFME 340
FE ++ IP L + +GE +V+ M+
Sbjct: 311 FEEKMIAEAIPELKASIKKGEDFVKNMK 338
>UniRef50_Q9VU28 Cluster: Malate dehydrogenase; n=3; Sophophora|Rep:
Malate dehydrogenase - Drosophila melanogaster (Fruit
fly)
Length = 349
Score = 199 bits (485), Expect = 1e-49
Identities = 106/317 (33%), Positives = 183/317 (57%), Gaps = 3/317 (0%)
Query: 24 RNVQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELSNLPGGPSVSAFI 83
R ++V+V+GA IG +SL L+R + +L L+D + +KG +LS++ V F
Sbjct: 21 RTLKVAVVGAGGGIGQPLSLLLRRCPGIDELALHDLSE-MKGIATDLSHISQTGKVIGFT 79
Query: 84 GDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAIST 143
G+ LE A+ +++VV+ + MPR PG R+ ++ AN + ++ AI+ + A +A T
Sbjct: 80 GEKELESAVSGADVVVVAAGMPRLPGMQRDHLMAANGNVAVKVATAISNASPRAHLAFIT 139
Query: 144 NPINYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEIQVPVIGGHS 203
NP+N ++P A+ V+ +G ++ ++FGIT +D RS+ F+ ++ I+ ++ +PVIGGH+
Sbjct: 140 NPVNMIVPAAAEVLMAHGTFDSRRLFGITTLDVVRSKKFIGDSMNISPDDVNIPVIGGHA 199
Query: 204 DKTIIPLFSNLTPRNYRIEPCQADMLTRLVRKAGTEVVMHKHGAESSTLAMAWSINEFID 263
TI+PL S P YR + + LT +++AGTEVV K G S+TL+MA++ F++
Sbjct: 200 GITILPLISQCQP-IYRCDLQEIQNLTHRIQEAGTEVVNAKAGKGSATLSMAYAGATFVN 258
Query: 264 IILDAILGYRVVVNC-YTANSNFGTKFFAGPTSVGPHGIIQACCHFPMSEFESYLLNRCI 322
+L I G ++ C + A+ FFA P +G GI + MS++E L + +
Sbjct: 259 SLLRGIAGQDGLIECAFVASKLTDAPFFASPLELGKDGIKRYIPLPQMSDYEKEALEKLL 318
Query: 323 PILSREVLEGEKYVEFM 339
PIL + EG + + +
Sbjct: 319 PILRQNADEGVNFAKMI 335
>UniRef50_Q42972 Cluster: Malate dehydrogenase, glyoxysomal
precursor; n=11; Eukaryota|Rep: Malate dehydrogenase,
glyoxysomal precursor - Oryza sativa subsp. japonica
(Rice)
Length = 356
Score = 199 bits (485), Expect = 1e-49
Identities = 108/312 (34%), Positives = 180/312 (57%), Gaps = 5/312 (1%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELSNLPGGPSVSAFIGDT 86
+V+++GA+ IG ++L +K N VS LHLYD + G ++S++ G V F+G
Sbjct: 46 KVAILGASGGIGQPLALLMKMNPLVSVLHLYDVVNT-PGVTADISHMNTGAVVRGFLGQP 104
Query: 87 NLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPI 146
LE A+ +LV++ + +PRKPG TR+ + NA +++ LC+ IA A V + +NP+
Sbjct: 105 QLENALTGMDLVIIPAGVPRKPGMTRDDLFNINAGIVRTLCEGIAKCCPNAIVNVISNPV 164
Query: 147 NYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEIQVPVIGGHSDKT 206
N +P A+ V K G Y+P ++ G+T +D R+ +FVA+ L ++ +++ VPVIGGH+ T
Sbjct: 165 NSTVPIAAEVFKKAGTYDPKRLLGVTTLDVVRANTFVAEVLGLDPRDVNVPVIGGHAGVT 224
Query: 207 IIPLFSNLTPR-NYRIEPCQADMLTRLVRKAGTEVVMHKHGAESSTLAMAWSINEFIDII 265
I+PL S + P ++ E + LT ++ GTEVV K GA S+TL+MA++ ++F D
Sbjct: 225 ILPLLSQVNPPCSFTSE--EISYLTTRIQNGGTEVVEAKAGAGSATLSMAYAASKFADAC 282
Query: 266 LDAILGYRVVVNC-YTANSNFGTKFFAGPTSVGPHGIIQACCHFPMSEFESYLLNRCIPI 324
L + G +V C + A+ FFA +G GI + P++EFE L +
Sbjct: 283 LRGLRGDAGIVECSFVASQVTELPFFASKVRLGRCGIEEILSLGPLNEFERAGLEKAKKE 342
Query: 325 LSREVLEGEKYV 336
L+ + +G ++
Sbjct: 343 LAESIQKGVAFI 354
>UniRef50_Q9VU29 Cluster: Malate dehydrogenase; n=5;
Protostomia|Rep: Malate dehydrogenase - Drosophila
melanogaster (Fruit fly)
Length = 347
Score = 198 bits (482), Expect = 2e-49
Identities = 107/319 (33%), Positives = 185/319 (57%), Gaps = 5/319 (1%)
Query: 24 RNVQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELSNLPGGPSVSAFI 83
R ++V+V+G+ IG +SL LK N ++S L LYD + G ++LS++ SV F
Sbjct: 26 RGLKVAVVGSVGGIGQPLSLLLKHNPQISTLSLYDIKNTT-GVGVDLSHINTRASVCPFE 84
Query: 84 GDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAIST 143
G L++A+ +++VV+ + +PRKPG RE ++ NA + + A + A +A T
Sbjct: 85 GKNGLKKAMDKADIVVIPAGLPRKPGMKREDLVDVNASVACEVAFAASEVCPGAMLAFIT 144
Query: 144 NPINYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEIQVPVIGGHS 203
NPIN ++P +T++ G Y+P+++FG+T +D R+++FVA L ++ Q++ +PVIGGH+
Sbjct: 145 NPINVIVPIVATILKAKGTYDPNRLFGVTTLDVVRAQTFVADILNVDPQKVNIPVIGGHT 204
Query: 204 DKTIIPLFSNLTPRNYRIEPCQADMLTRLVRKAGTEVVMHKHGAESSTLAMAWSINEFID 263
+TI+P+ S P ++ + + L + ++ AGTEVV K G S+TL+MA++ +F+
Sbjct: 205 GRTILPILSQCDP-PFKGTDKEREALIQRIQNAGTEVVNAKDGLGSATLSMAFAATQFVS 263
Query: 264 IILDAILGYR--VVVNC-YTANSNFGTKFFAGPTSVGPHGIIQACCHFPMSEFESYLLNR 320
++ I G + +V C Y + +FFA P +GP G+ + + + E LN
Sbjct: 264 SLIKGIKGSKDECIVECAYVESDVTEAQFFATPLILGPQGVKENTGLPDLDDEERKALNG 323
Query: 321 CIPILSREVLEGEKYVEFM 339
+PIL + +G K E M
Sbjct: 324 MLPILKESIAKGIKLGEGM 342
>UniRef50_Q9SN86 Cluster: Malate dehydrogenase, chloroplast
precursor; n=41; cellular organisms|Rep: Malate
dehydrogenase, chloroplast precursor - Arabidopsis
thaliana (Mouse-ear cress)
Length = 403
Score = 187 bits (455), Expect = 4e-46
Identities = 105/277 (37%), Positives = 160/277 (57%), Gaps = 5/277 (1%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELSNLPGGPSVSAFIGDT 86
+V+V+GAA IG +SL +K + VS LHLYD + +KG +LS+ V F G +
Sbjct: 84 KVAVLGAAGGIGQPLSLLIKMSPLVSTLHLYDIAN-VKGVAADLSHCNTPSQVRDFTGPS 142
Query: 87 NLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPI 146
L + N+VV+ + +PRKPG TR+ + NA +++ L +A+A AF+ I +NP+
Sbjct: 143 ELADCLKDVNVVVIPAGVPRKPGMTRDDLFNINANIVKTLVEAVAENCPNAFIHIISNPV 202
Query: 147 NYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEIQVPVIGGHSDKT 206
N +P A+ V+ K G Y+P K+FG+T +D R+ +FV++ + ++ VPVIGGH+ T
Sbjct: 203 NSTVPIAAEVLKKKGVYDPKKLFGVTTLDVVRANTFVSQKKNLKLIDVDVPVIGGHAGIT 262
Query: 207 IIPLFSNLTPR-NYRIEPCQADMLTRLVRKAGTEVVMHKHGAESSTLAMAWSINEFIDII 265
I+PL S P N+ E Q LT ++ AGTEVV K GA S+TL+MA++ F++
Sbjct: 263 ILPLLSKTKPSVNFTDEEIQE--LTVRIQNAGTEVVDAKAGAGSATLSMAYAAARFVESS 320
Query: 266 LDAILGYRVVVNCYTANSNF-GTKFFAGPTSVGPHGI 301
L A+ G V C S FFA +G +G+
Sbjct: 321 LRALDGDGDVYECSFVESTLTDLPFFASRVKIGKNGL 357
>UniRef50_UPI0000D571DB Cluster: PREDICTED: similar to CG7998-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG7998-PA - Tribolium castaneum
Length = 376
Score = 178 bits (434), Expect = 1e-43
Identities = 98/310 (31%), Positives = 177/310 (57%), Gaps = 6/310 (1%)
Query: 26 VQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELSNLPGGPSVSAFIGD 85
++V+++GA + G VSL LK++ + +L LYD ++G +L+ + V++F G+
Sbjct: 29 MKVTILGAGGNTGKSVSLMLKQSPFIDELCLYDTQS-LEGFANDLNYVDTKCRVTSFFGN 87
Query: 86 TNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNP 145
++++A+ SN++V++S + NAP+++ L +IA + ++ VAI P
Sbjct: 88 KDIQKALTKSNIIVVLSCCHAAEPTNYASLFDRNAPIVKDLATSIAKFSPKSTVAIGVEP 147
Query: 146 INYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEIQVPVIGGHSDK 205
IN ++P S +M KYG YNP +FGIT +D R+ FVA+ L + + + VP++GGHS+K
Sbjct: 148 INSVVPMFSEIMKKYGHYNPYSIFGITTVDVVRTNKFVAEILGLEPECVTVPIVGGHSEK 207
Query: 206 TIIPLFSNLTPRNYRIEPCQADMLTRLVRKAGTEVVMHKHGAESSTLAMAWSINEFIDII 265
TI+P+ S P N + + + +T VRKA ++ K ++ + LA A++++ F+ +
Sbjct: 208 TIVPVLSQAKPCN-ELTNEELEDITISVRKANEHLL--KVRSDGAYLASAFAVSRFVISL 264
Query: 266 LDAILGYRVVVNCYTANSNF--GTKFFAGPTSVGPHGIIQACCHFPMSEFESYLLNRCIP 323
+ A G +V C SN K+ P +GP G+ + +S++E+ LL IP
Sbjct: 265 VKAARGQNEIVECSYVKSNVHPQLKYMVTPLLLGPGGVAKNLGLPELSDYETCLLENAIP 324
Query: 324 ILSREVLEGE 333
+L+ E+ +GE
Sbjct: 325 VLAEEIKKGE 334
>UniRef50_Q4Q3J3 Cluster: Malate dehydrogenase, putative; n=3;
Leishmania|Rep: Malate dehydrogenase, putative -
Leishmania major
Length = 331
Score = 178 bits (434), Expect = 1e-43
Identities = 104/313 (33%), Positives = 177/313 (56%), Gaps = 8/313 (2%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELSNLPGGPSVSAFIGDT 86
+V+V+GA+ IG ++L L +N +VS+L LYD +G ++LS+ P V+ +
Sbjct: 10 KVTVLGASGAIGQPLALALVQNKRVSELALYDIVQP-RGVAVDLSHFPRKVKVTGYPTKW 68
Query: 87 NLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPI 146
+ +A+ ++LV+M + MPR+PG T + + NA + L A+A ++ +AI +NP+
Sbjct: 69 -IHKALDGADLVLMSAGMPRRPGMTHDDLFNTNALTVNELSAAVARYAPKSVLAIISNPL 127
Query: 147 NYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEIQVPVIGGHSDKT 206
N ++P A+ + + G Y+P K+FGI ++ R+R + + + + VPVIGGHS +T
Sbjct: 128 NSMVPVAAETLQRAGVYDPRKLFGIISLNMMRARKMLGDFTGQDPEMLDVPVIGGHSGQT 187
Query: 207 IIPLFSNLTPRNYRIEPCQADMLTRLVRKAGTEVVMHKHGAESSTLAMAWSINEFIDIIL 266
I+PLFS+ + Q + LT VR G EVV K G SS+L+MA++ E+ D +L
Sbjct: 188 IVPLFSH---SGVELRQEQVEYLTHRVRVGGDEVVKAKEGRGSSSLSMAFAAAEWADGVL 244
Query: 267 DAILGYRVVVNC-YTANSNFGTK--FFAGPTSVGPHGIIQACCHFPMSEFESYLLNRCIP 323
A+ G + ++ C + + F K FF V GI + P++E+E L+RC+P
Sbjct: 245 RAMDGEKTLLQCSFVESPLFADKCRFFGSTVEVCKEGIERVLPLPPLNEYEEEQLDRCLP 304
Query: 324 ILSREVLEGEKYV 336
L + + +G +V
Sbjct: 305 DLEKNIRKGLAFV 317
>UniRef50_A2QMH9 Cluster: Malate dehydrogenase; n=7; Fungi/Metazoa
group|Rep: Malate dehydrogenase - Aspergillus niger
Length = 340
Score = 167 bits (406), Expect = 4e-40
Identities = 102/316 (32%), Positives = 166/316 (52%), Gaps = 8/316 (2%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELSNLPGGPSVSAFIGD- 85
+V+V+GAA IG +SL +K+N V+ L LYD G ++S++ +V +
Sbjct: 25 KVAVLGAAGGIGQPLSLLMKQNPLVTDLALYDIRGG-PGVAADISHINTNSTVKGYEPTP 83
Query: 86 TNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNP 145
+ L A+ S ++++ + +PRKPG TR+ + NA +++ L KA A EA + + +NP
Sbjct: 84 SGLRDALKGSEIILIPAGVPRKPGMTRDDLFNTNASIVRDLAKAAAEAAPEANILVISNP 143
Query: 146 INYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEIQVPVIGGHSDK 205
+N +P S V G YNP ++FG+T +D R+ F+++ N V VIGGHS
Sbjct: 144 VNSTVPIVSEVYKSKGVYNPKRLFGVTTLDVVRASRFISQVKGTNPANEAVTVIGGHSGV 203
Query: 206 TIIPLFSNLTPRNYRIEPCQADMLTRLVRKAGTEVVMHKHGAESSTLAMAWSINEFIDII 265
TI+PL S + I D L ++ G EVV K GA S+TL+MA + F D +
Sbjct: 204 TIVPLLSQ--SNHPDISGTVRDELVNRIQFGGDEVVKAKDGAGSATLSMAMAGARFADSL 261
Query: 266 LDAILGYRVVVNCYTANS----NFGTKFFAGPTSVGPHGIIQACCHFPMSEFESYLLNRC 321
L A G + +V S + G FFA +GP+G+ + P++E+E L+
Sbjct: 262 LRAANGEKGIVEPTFVESPLFKDQGVNFFASKVELGPNGVEKIHEVGPVNEYEQGLIQTA 321
Query: 322 IPILSREVLEGEKYVE 337
+ L + + +G +V+
Sbjct: 322 LGDLKKNIQKGVDFVK 337
>UniRef50_Q9Y7R8 Cluster: Malate dehydrogenase; n=13; Dikarya|Rep:
Malate dehydrogenase - Schizosaccharomyces pombe
(Fission yeast)
Length = 341
Score = 157 bits (381), Expect = 4e-37
Identities = 95/318 (29%), Positives = 166/318 (52%), Gaps = 9/318 (2%)
Query: 24 RNVQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELSNLPGGPSVSAFI 83
R +V+V+GA IG +S+ LK N KVS+L L+D G ++ ++ +V +
Sbjct: 27 RAFKVAVLGAGGGIGQPLSMLLKLNDKVSELALFDIRGA-PGVAADIGHINTTSNVVGYA 85
Query: 84 -GDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAIS 142
D LE+A++ +++V++ + +PRKPG TR+ + NA +++ L A EA +
Sbjct: 86 PDDKGLEKALNGADVVIIPAGVPRKPGMTRDDLFATNASIVRDLAFAAGETCPEAKYLVV 145
Query: 143 TNPINYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEIQVPVIGGH 202
TNP+N +P + + G + P +FG+T +D+ R+ F ++ A+ + +PV+GGH
Sbjct: 146 TNPVNSTVPIFKKALERVGVHQPKHLFGVTTLDSVRASRFTSQVTNGKAELLHIPVVGGH 205
Query: 203 SDKTIIPLFSNLTPRNYRIEPCQADMLTRLVRKAGTEVVMHKHGAESSTLAMAWSINEFI 262
S TI+PL L+ + + D L ++ G EVV K GA S+TL+MA++
Sbjct: 206 SGATIVPL---LSQGGVELTGEKRDALIHRIQFGGDEVVKAKAGAGSATLSMAYAGARMA 262
Query: 263 DIILDAILGYRVVVNCYTANS----NFGTKFFAGPTSVGPHGIIQACCHFPMSEFESYLL 318
+L A+ G V C S + G FFA ++G G+ ++++E LL
Sbjct: 263 SSVLRALAGESGVEECTFVESPLYKDQGIDFFASRVTLGKDGVDTIHPVGKINDYEESLL 322
Query: 319 NRCIPILSREVLEGEKYV 336
+ L + + +GE++V
Sbjct: 323 KVALGELKKSITKGEQFV 340
>UniRef50_Q86DP2 Cluster: Malate dehydrogenase; n=11; Fungi/Metazoa
group|Rep: Malate dehydrogenase - Plicopurpura patula
Length = 229
Score = 143 bits (346), Expect = 7e-33
Identities = 81/224 (36%), Positives = 129/224 (57%), Gaps = 4/224 (1%)
Query: 115 MLGANAPLIQRLCKAIAAQNQEAFVAISTNPINYLIPFASTVMYKYGCYNPSKMFGITHI 174
+ NA +++ L IA A + I TNP+N +P AS V+ K G Y+P ++FG+T +
Sbjct: 2 LFNTNAGIVRDLTDRIAKVCPTAMLGIITNPVNSTVPIASEVLKKRGVYDPKRVFGVTTL 61
Query: 175 DTSRSRSFVAKALKINAQEIQVPVIGGHSDKTIIPLFSNLTPR-NYRIEPCQADMLTRLV 233
D RS +F+A+A ++ + VPVIGGHS TIIPL S TP ++ E + + L+ +
Sbjct: 62 DVVRSNTFIAEAKGLDVTKTNVPVIGGHSGVTIIPLISQCTPPVSFPTE--EREKLSVRI 119
Query: 234 RKAGTEVVMHKHGAESSTLAMAWSINEFIDIILDAILGYRVVVNC-YTANSNFGTKFFAG 292
+ AGTEVV K GA S+TL+MA++ EF +++A+ G VV C + + +FA
Sbjct: 120 QNAGTEVVEAKAGAGSATLSMAYAAAEFCRSLIEALNGKERVVQCAFVKSDETEAAYFAT 179
Query: 293 PTSVGPHGIIQACCHFPMSEFESYLLNRCIPILSREVLEGEKYV 336
P +G +G+ + + +FE LL +P L + +GE++V
Sbjct: 180 PLLLGKNGVEKNLGLGKLIDFEVNLLKAAMPELIANIKKGEEFV 223
>UniRef50_Q6BM17 Cluster: Malate dehydrogenase; n=4; Eukaryota|Rep:
Malate dehydrogenase - Debaryomyces hansenii (Yeast)
(Torulaspora hansenii)
Length = 346
Score = 141 bits (342), Expect = 2e-32
Identities = 85/256 (33%), Positives = 147/256 (57%), Gaps = 11/256 (4%)
Query: 26 VQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELSNLPGGPSVSAFIGD 85
V+V+V GAA IG +SL LK N +VS+L L+D + G +LS++ V+ +
Sbjct: 2 VKVTVCGAAGGIGQPLSLLLKLNPQVSELSLFDVVNA-NGVAADLSHICSPAKVTGYQPS 60
Query: 86 TN-----LEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVA 140
+ +++A+ +S+LVV+ + +PRKPG TR + NA +I+ + +I A +
Sbjct: 61 SKEDRDTIQKALVNSDLVVIPAGVPRKPGMTRADLFNINASIIRDIVGSIGKACPNAAIL 120
Query: 141 ISTNPINYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEI--QVPV 198
I +NP+N +P A+ V+ K G +NP K+FG+T +D+ R+ +F+ + +K + Q+ V
Sbjct: 121 IISNPVNSTVPIAAEVLKKLGVFNPKKLFGVTTLDSVRAETFLGELIKETPTSLKGQISV 180
Query: 199 IGGHSDKTIIPLF---SNLTPRNYRIEPCQADMLTRLVRKAGTEVVMHKHGAESSTLAMA 255
IGGHS TI+PL + + + + Q + V+ G EVV K+GA S+TL+MA
Sbjct: 181 IGGHSGDTIVPLVHATALVAKKVSGLSKSQYNEFIHRVQFGGDEVVKAKNGAGSATLSMA 240
Query: 256 WSINEFIDIILDAILG 271
++ F + ++ ++ G
Sbjct: 241 YAGYRFAEKVIGSLNG 256
>UniRef50_Q4QDF0 Cluster: Glycosomal malate dehydrogenase; n=9;
Trypanosomatidae|Rep: Glycosomal malate dehydrogenase -
Leishmania major
Length = 322
Score = 138 bits (335), Expect = 1e-31
Identities = 102/320 (31%), Positives = 160/320 (50%), Gaps = 14/320 (4%)
Query: 26 VQVSVIGAASDIGSYVSLFLKRNSKV-SKLHLYDDDDRIKGTELELSNLPGGPSVSAF-- 82
V V V+GAA IG +SL L R S L L+D G +LS++ F
Sbjct: 2 VNVCVVGAAGGIGQSLSLLLVRQLPYGSTLSLFDVVGAA-GVAADLSHVDNAGVQVKFAE 60
Query: 83 --IG---DTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEA 137
IG D L + ++ VMV+ +PRKPG TR+ + NA +I L A+ + +A
Sbjct: 61 GKIGHKRDPALAELAKGVDVFVMVAGVPRKPGMTRDDLFKINAGIILDLVLTCASSSPKA 120
Query: 138 FVAISTNPINYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEIQVP 197
I TNP+N + A+ + G Y+ +++ G++ +D R+ F+ +A K QVP
Sbjct: 121 VFCIVTNPVNSTVAIAAEALKSLGVYDRNRLLGVSLLDGLRATCFINEARKPLVVS-QVP 179
Query: 198 VIGGHSDKTIIPLFSNLTPRNYRIEPCQADMLTRLVRKAGTEVVMHKHGAESSTLAMAWS 257
V+GGHSD TI+PLF L E D + + V+ AGTEVV K G S+TL+MA +
Sbjct: 180 VVGGHSDTTIVPLFYQLP--GPLPEQATLDKIVKRVQVAGTEVVKAKAGRGSATLSMAEA 237
Query: 258 INEFIDIILDAILGY-RVVVNCYT-ANSNFGTKFFAGPTSVGPHGIIQACCHFPMSEFES 315
F +++ + G +V Y + T F A P +G +GI + P+ E
Sbjct: 238 GARFALKVVEGLTGTGNPLVYAYVDTDGQHETTFLAIPVVLGMNGIEKRLPIGPLHSTEE 297
Query: 316 YLLNRCIPILSREVLEGEKY 335
LL +P++ + +++G ++
Sbjct: 298 TLLKAALPVIKKNIVKGSEF 317
>UniRef50_UPI0000DB76D8 Cluster: PREDICTED: similar to CG7998-PA;
n=2; Apis mellifera|Rep: PREDICTED: similar to CG7998-PA
- Apis mellifera
Length = 333
Score = 137 bits (332), Expect = 3e-31
Identities = 86/311 (27%), Positives = 159/311 (51%), Gaps = 7/311 (2%)
Query: 26 VQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELSNLPGGPSVSAFIGD 85
++V+++GA S G+ +SLFLK++ + +L ++D++ G L+L+ + VS
Sbjct: 1 MKVAILGARSKTGNCLSLFLKQSPLIDELAIFDNNSSTYGLALDLNYIDTKCKVSTCNHP 60
Query: 86 TN-LEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTN 144
LE+ + + +V++V+ + N ++L +NA ++ L I + +A +AI N
Sbjct: 61 EKCLEETLQGAKIVMIVTD---RTSNESNEVLKSNAIILSDLLPNIIKFSPQAMLAIVMN 117
Query: 145 PINYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEIQVPVIGGHSD 204
PIN LIP + K G Y +++FG+ + + ++ SF A + I + +PVIGG
Sbjct: 118 PINSLIPLTMEMYKKAGIYEYNRIFGVMNFECLKANSFTADLINIEPECTMIPVIGGGCS 177
Query: 205 KTIIPLFSNLTPRNYRIEPCQADMLTRLVRKAGTEVVMHKHGAESSTLAMAWSINEFIDI 264
+T IPLFS P N +I +A LT +R + + E+++ A++++ F
Sbjct: 178 ETCIPLFSQAKPSN-KISQVEARRLTYAIRMSNNNTLNPSENKETNSFALSYAAARFCMS 236
Query: 265 ILDAILGYRVVVNCYTANSNF--GTKFFAGPTSVGPHGIIQACCHFPMSEFESYLLNRCI 322
+ A+ VV C S +FA P +GP+GI + P++++E LL +
Sbjct: 237 LCKALRHQGNVVECAYVRSCAIPELTYFAAPLELGPNGIQKHLDIPPLNDYECELLKAAV 296
Query: 323 PILSREVLEGE 333
P + + + GE
Sbjct: 297 PRIKKAIKLGE 307
>UniRef50_Q5ENS5 Cluster: Malate dehydrogenase; n=1; Heterocapsa
triquetra|Rep: Malate dehydrogenase - Heterocapsa
triquetra (Dinoflagellate)
Length = 402
Score = 135 bits (326), Expect = 2e-30
Identities = 95/320 (29%), Positives = 158/320 (49%), Gaps = 12/320 (3%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRI---KGTELELSNLPGGPSVSAFI 83
+V V G A IG + L + + V +L ++D + + +G +L +L +V ++
Sbjct: 82 KVCVCGGAGGIGQPLCLLMAMDPNVKELCVFDLNVAMVPAQGVATDLGHLEKKAAVKGYV 141
Query: 84 GDT------NLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEA 137
+ NLE+ + +LV++ + MPRKPG TR+ + NA + + + +A A +A
Sbjct: 142 MEVGQKPVDNLEECLTGCHLVLIPAGMPRKPGQTRDDLFKINADIAKGIVEACAKYCPDA 201
Query: 138 FVAISTNPINYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEIQVP 197
+ + NP+N ++P A +YK +P K+ GIT +D R+ FV + L + VP
Sbjct: 202 MLGMIVNPVNSVVP-AMAELYKKKGLDPMKIVGITTLDVVRANKFVVR-LPAPPDRVNVP 259
Query: 198 VIGGHSDKTIIPLFSNLTPRNYRIEPCQADMLTRLVRKAGTEVVMHKHGAESSTLAMAWS 257
VIGGH+ TI+PLFS I+ + L + V+ AGT+VV K+G S+TL+MA++
Sbjct: 260 VIGGHAGTTILPLFSQ-DKHAKTIDAEKIPDLDKHVQDAGTDVVNAKNGKGSATLSMAYA 318
Query: 258 INEFIDIILDAILGYRVVVNCYTANSNFGTKFFAGPTSVGPHGIIQACCHFPMSEFESYL 317
+L + G R Y + +FA G GI + ++E+E+
Sbjct: 319 GARLGKSVLAGLAGQRRTECAYCKSEITDLPYFAQKVVFGKEGISKVLPLGELNEYETKR 378
Query: 318 LNRCIPILSREVLEGEKYVE 337
L L E+ G KY E
Sbjct: 379 LEEVKVQLKGEIESGLKYAE 398
>UniRef50_Q017A6 Cluster: Malate dehydrogenase; n=2; cellular
organisms|Rep: Malate dehydrogenase - Ostreococcus tauri
Length = 477
Score = 130 bits (315), Expect = 4e-29
Identities = 71/221 (32%), Positives = 118/221 (53%), Gaps = 1/221 (0%)
Query: 111 TREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPINYLIPFASTVMYKYGCYNPSKMFG 170
TR+ + N +++ L +AIA A + + +NP+N +P A+ V+ G Y+P K+FG
Sbjct: 2 TRDDLFAINGGIVKGLVEAIADNCPNAMINMISNPVNSTVPIAAEVLKAKGKYDPKKLFG 61
Query: 171 ITHIDTSRSRSFVAKALKINAQEIQVPVIGGHSDKTIIPLFSNLTPRNYRIEPCQADMLT 230
+T +D R+++F A+ + ++ VPV+GGH+ TI+PLFS TP+ + D LT
Sbjct: 62 VTTLDVVRAKTFYAEKAGLETSKVDVPVVGGHAGITILPLFSQATPQAKNLSADDIDALT 121
Query: 231 RLVRKAGTEVVMHKHGAESSTLAMAWSINEFIDIILDAILGYRVVVNC-YTANSNFGTKF 289
+ + GTEVV K G S+TL+MA++ F D L A G +V C Y + +
Sbjct: 122 KRTQDGGTEVVAAKAGKGSATLSMAYAGALFADACLRAKNGEANIVECTYVESKVTKVPY 181
Query: 290 FAGPTSVGPHGIIQACCHFPMSEFESYLLNRCIPILSREVL 330
F+ ++G G+ +S +E L+ +P L +L
Sbjct: 182 FSSKVTLGRDGVDTVHGLGTLSAYEQSALDAMMPQLEYSLL 222
>UniRef50_A7TL95 Cluster: Putative uncharacterized protein; n=1;
Vanderwaltozyma polyspora DSM 70294|Rep: Putative
uncharacterized protein - Vanderwaltozyma polyspora DSM
70294
Length = 365
Score = 126 bits (304), Expect = 8e-28
Identities = 88/260 (33%), Positives = 135/260 (51%), Gaps = 19/260 (7%)
Query: 26 VQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELSNLPGGPSVSAFIGD 85
V+V V+GA+ IG +SL LK N VS L LYD D G +LS++ + D
Sbjct: 2 VKVCVLGASGGIGQPLSLLLKLNPYVSDLALYDISDITAGVAKDLSHINTNSDSEGYNKD 61
Query: 86 TNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRL-CKAIAAQNQEAFVAISTN 144
+ + + S LV++ + +PRKPG TR+ + NA +IQ L K + I +N
Sbjct: 62 EDFKNLLEGSELVIVTAGIPRKPGMTRDDLFKINAKIIQNLTVKYAKFAPVHCKLLIISN 121
Query: 145 PINYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKAL---KINAQEI------- 194
P+N LIP + G NPS++FGIT +D RS++F+ L K+ + I
Sbjct: 122 PVNSLIPVVIETLKINGRLNPSQVFGITMLDIIRSQTFLNDLLNDKKLRSGSITSKQFDK 181
Query: 195 -----QVPVIGGHSDKTIIPLFSNLTPRNYRIEPCQADMLTRLVRKAGTEVVMHKHGAES 249
+ VIGGHS T++P+ LT +N + + D L + ++ G E+V K+G S
Sbjct: 182 TLNLNNINVIGGHSAPTMVPI---LTNKNLIHQQDEIDALYKKIKFGGDEIVKAKNGKGS 238
Query: 250 STLAMAWSINEFIDIILDAI 269
+TL+MA++ F + IL I
Sbjct: 239 ATLSMAYAGYFFANEILKKI 258
>UniRef50_A7SQS1 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 254
Score = 125 bits (301), Expect = 2e-27
Identities = 81/273 (29%), Positives = 141/273 (51%), Gaps = 28/273 (10%)
Query: 65 GTELELSNLPGGPSVSAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQ 124
G +LS++ V++ G +L+ A+ ++V + + +PRKPG TR+ + NA +++
Sbjct: 7 GVAADLSHISTRAKVTSHQGPDDLKAALEGCSVVAIPAGVPRKPGMTRDDLFNTNASIVK 66
Query: 125 RLCKAIAAQNQEAFVAISTNPINYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVA 184
L +A A +A + I +NP+N +P AS V K G Y+P+++ G+T +D R+ +FVA
Sbjct: 67 NLSEACAKHCPKAIICIISNPVNSTVPIASEVYKKAGVYDPARILGVTTLDIVRAHTFVA 126
Query: 185 KALKINAQEIQVPVIGGHSDKTIIPLFSNLTPRNYRIEPCQADMLTRLVRKAGTEVVMHK 244
+A P + D LT R ++ AGTEVV K
Sbjct: 127 EAK-------TTPCVNFTQDD-----LEKLTDR---------------IQNAGTEVVNAK 159
Query: 245 HGAESSTLAMAWSINEFIDIILDAILGYRVVVNCYTANSNF-GTKFFAGPTSVGPHGIIQ 303
GA S+TL+MA++ EF+ +++A+ G + VV C S+ +FA P +G +G+ +
Sbjct: 160 AGAGSATLSMAYAGKEFVHSVIEALNGKKDVVQCAFIKSHLTEAGYFATPVLLGTNGVEK 219
Query: 304 ACCHFPMSEFESYLLNRCIPILSREVLEGEKYV 336
+S++E + IP L + + +GE +V
Sbjct: 220 NLGMGKLSDYEQKKMGEVIPELLKNIKKGEDFV 252
>UniRef50_P32419 Cluster: Malate dehydrogenase, peroxisomal; n=24;
Eukaryota|Rep: Malate dehydrogenase, peroxisomal -
Saccharomyces cerevisiae (Baker's yeast)
Length = 343
Score = 122 bits (293), Expect = 2e-26
Identities = 76/252 (30%), Positives = 142/252 (56%), Gaps = 15/252 (5%)
Query: 26 VQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELSNLPGGPSVSAFIGD 85
V+V+++GA+ +G +SL LK + VS+L LYD +G +LS++ S + D
Sbjct: 2 VKVAILGASGGVGQPLSLLLKLSPYVSELALYDIR-AAEGIGKDLSHINTNSSCVGYDKD 60
Query: 86 TNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNP 145
+ +E + ++ +V++ + +PRKPG TR+ + NA +++ L A+ A + + +NP
Sbjct: 61 S-IENTLSNAQVVLIPAGVPRKPGLTRDDLFKMNAGIVKSLVTAVGKFAPNARILVISNP 119
Query: 146 INYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEI----------- 194
+N L+P A + K G + P + G+T++D R+ +F+ L + +I
Sbjct: 120 VNSLVPIAVETLKKMGKFKPGNVMGVTNLDLVRAETFLVDYLMLKNPKIGQEQDKTTMHR 179
Query: 195 QVPVIGGHSDKTIIPLFSNLTPRNYRIEPCQADMLTRLVRKAGTEVVMHKHGAESSTLAM 254
+V VIGGHS +TIIP+ ++ + ++++ Q + V+ G E+V K GA S+TL+M
Sbjct: 180 KVTVIGGHSGETIIPIITDKS-LVFQLDK-QYEHFIHRVQFGGDEIVKAKQGAGSATLSM 237
Query: 255 AWSINEFIDIIL 266
A++ +F + +L
Sbjct: 238 AFAGAKFAEEVL 249
>UniRef50_Q6CP51 Cluster: Similar to sp|P22133 Saccharomyces
cerevisiae YOL126c MDH2 malate dehydrogenase; n=1;
Kluyveromyces lactis|Rep: Similar to sp|P22133
Saccharomyces cerevisiae YOL126c MDH2 malate
dehydrogenase - Kluyveromyces lactis (Yeast) (Candida
sphaerica)
Length = 404
Score = 121 bits (292), Expect = 2e-26
Identities = 90/274 (32%), Positives = 151/274 (55%), Gaps = 25/274 (9%)
Query: 22 QKRNVQVSVIGAASDIGSYVSLFLKRN---------SKVSKLHLYD-DDDRIKGTELELS 71
+K +++SV+GAA IG +SL LK N S +L LYD + D I GT +LS
Sbjct: 43 EKEILKISVLGAAGGIGQSLSLLLKSNAGFLLPHETSTHIRLSLYDVNKDAIVGTAADLS 102
Query: 72 NLPGGPSVSA-FIGDTN--LEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCK 128
++ + +A + D+N + Q + ++++V++ + +PRKPG +R+ ++G NA +I+ L +
Sbjct: 103 HIDTPITTTAHYPDDSNGGIGQCLSNASVVIIPAGVPRKPGMSRDDLIGVNAKIIKSLGE 162
Query: 129 AIA--AQNQEAFVAISTNPINYLIPFASTVMYK---YGCYN-PSKMFGITHIDTSRSRSF 182
IA + V + +NPIN L+P + + + G N S+++GIT +D RS +F
Sbjct: 163 DIAKYCDLNKVHVLVISNPINSLVPLLTNTLIRSDANGNSNIESRVYGITQLDLVRSSTF 222
Query: 183 VAK--ALKINAQEIQVPVIGGHSDKTIIPLFSNLTPRNYRIEPCQADMLTRLVRK---AG 237
V + K N + +PVIGGHS TIIP+FS L M ++V + G
Sbjct: 223 VQQLNGFKSNTSPV-IPVIGGHSGDTIIPVFSTLERDPEYANLLDNGMRLKMVHRVQYGG 281
Query: 238 TEVVMHKHGAESSTLAMAWSINEFIDIILDAILG 271
E+V K+G S+TL+MA++ + +D ++G
Sbjct: 282 DEIVKAKNGNGSATLSMAYAGFKIAAKFIDLLVG 315
>UniRef50_Q75AT4 Cluster: ADL164Cp; n=2; Saccharomycetales|Rep:
ADL164Cp - Ashbya gossypii (Yeast) (Eremothecium
gossypii)
Length = 381
Score = 121 bits (291), Expect = 3e-26
Identities = 87/272 (31%), Positives = 147/272 (54%), Gaps = 26/272 (9%)
Query: 24 RNVQVSVIGAASDIGSYVSLFLKR-------NSKVS-KLHLYD-DDDRIKGTELELSNLP 74
+ V+V+V+GAA IG +SL LK ++ S +L LYD D + G +LS++
Sbjct: 22 QRVRVAVLGAAGGIGQPLSLLLKTQLAQVLGDANASLELALYDVAADALAGVAADLSHVN 81
Query: 75 GGPSVSAFIGDTN-----LEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKA 129
VS + + L +A+ +++VV+ + +PRKPG TR+ ++ NA +I+ L K
Sbjct: 82 TPVEVSHHVPSSREDEEALREALTGASVVVIPAGVPRKPGMTRDDLININAGIIKTLAKG 141
Query: 130 IAA--QNQEAFVAISTNPINYLIPFASTVMYKYGCYNPS-------KMFGITHIDTSRSR 180
IA ++ FV + +NP+N L+P + ++ + ++FG+T +D R+
Sbjct: 142 IAGACDLEKVFVLVISNPVNSLVPVMVRQLIRHAEAKQAPHAGVERRVFGVTQLDMVRAS 201
Query: 181 SFVAKALKINAQEIQVPVIGGHSDKTIIPLFSNLTPR-NYRIEPCQADMLTRLVRKAGTE 239
+FV ++ + VPVIGGHS +TI+PLF + R + +E Q LT V+ G E
Sbjct: 202 AFVRSLGELGNEVPSVPVIGGHSGETILPLFGPVQQRLQFSLE--QRKKLTHRVQYGGDE 259
Query: 240 VVMHKHGAESSTLAMAWSINEFIDIILDAILG 271
+V K GA S+TL+MA++ + + +LG
Sbjct: 260 IVAAKKGAGSATLSMAYAAYVVAERFTNLVLG 291
>UniRef50_P22133 Cluster: Malate dehydrogenase, cytoplasmic; n=3;
Saccharomycetaceae|Rep: Malate dehydrogenase,
cytoplasmic - Saccharomyces cerevisiae (Baker's yeast)
Length = 377
Score = 118 bits (284), Expect = 2e-25
Identities = 87/279 (31%), Positives = 152/279 (54%), Gaps = 32/279 (11%)
Query: 21 LQKRNVQVSVIGAASDIGSYVSLFLKR---------NSKVSKLHL--YD-DDDRIKGTEL 68
+++ +++++++GAA IG +SL LK N V+ +HL YD + + I G
Sbjct: 9 IEQDSLKIAILGAAGGIGQSLSLLLKAQLQYQLKESNRSVTHIHLALYDVNQEAINGVTA 68
Query: 69 ELSNLPGGPSVSAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCK 128
+LS++ SVS+ +E +H++++VV+ + +PRKPG TR+ + NA +I +L
Sbjct: 69 DLSHIDTPISVSSHSPAGGIENCLHNASIVVIPAGVPRKPGMTRDDLFNVNAGIISQLGD 128
Query: 129 AIA--AQNQEAFVAISTNPINYLIP-FASTVMYKYGCYNPS----KMFGITHIDTSRSRS 181
+IA + FV + +NP+N L+P S ++ + S ++ G+T +D R+ +
Sbjct: 129 SIAECCDLSKVFVLVISNPVNSLVPVMVSNILKNHPQSRNSGIERRIMGVTKLDIVRAST 188
Query: 182 FVAK-------ALKINAQEIQVPVIGGHSDKTIIPLFSNLTPRNYRIEPCQADMLTRLVR 234
F+ + ++N+ VPVIGGHS +TIIPLFS + R+ Q L V+
Sbjct: 189 FLREINIESGLTPRVNSMP-DVPVIGGHSGETIIPLFSQSNFLS-RLNEDQLKYLIHRVQ 246
Query: 235 KAGTEVVMHKHGAESSTLAMAWS----INEFIDIILDAI 269
G EVV K+G S+TL+MA + + +F+ ++L I
Sbjct: 247 YGGDEVVKAKNGKGSATLSMAHAGYKCVVQFVSLLLGNI 285
>UniRef50_Q6FL22 Cluster: Malate dehydrogenase; n=1; Candida
glabrata|Rep: Malate dehydrogenase - Candida glabrata
(Yeast) (Torulopsis glabrata)
Length = 373
Score = 116 bits (280), Expect = 7e-25
Identities = 82/264 (31%), Positives = 145/264 (54%), Gaps = 23/264 (8%)
Query: 26 VQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELSNLPGGPSVSAFIGD 85
V+V+V+GA+ +G +SL LK N+ +S+L LYD +G +LS++ + D
Sbjct: 2 VKVAVLGASGGVGQPLSLLLKLNTMISELALYDIK-LAEGVATDLSHINTNADCVGYSTD 60
Query: 86 TNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNP 145
++ QA+ + +VV+ + +PR+PG TR+ + NA +++ L +A A + I +NP
Sbjct: 61 -DIGQALKGAAVVVIPAGVPRRPGITRDDLFKLNAGIVKNLVSNVAKHCPNARLLIISNP 119
Query: 146 INYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKIN-AQEI---------- 194
+N LIP A + + G + + G+T +D R+ +F+A+ L + A+EI
Sbjct: 120 VNSLIPVAVETLKRCGVFQAGNVMGVTTLDLVRAETFLAEYLNTHEAKEIGGIAGERTYD 179
Query: 195 ------QVPVIGGHSDKTIIPL-FSNLTPRNYRIEPCQADMLTRLVRKAGTEVV--MHKH 245
V VIGGHS +TI+PL F+++ R + + D V+ G EVV K
Sbjct: 180 KSKMYKYVGVIGGHSGETIVPLVFNHMMTRTLE-KTNKYDEFINRVQYGGDEVVKAKAKD 238
Query: 246 GAESSTLAMAWSINEFIDIILDAI 269
G+ S+TL+MA + ++F++ +L ++
Sbjct: 239 GSGSATLSMALAGSKFVNEVLQSV 262
>UniRef50_UPI0000D55CD8 Cluster: PREDICTED: similar to Malate
DeHydrogenase family member (mdh-1); n=1; Tribolium
castaneum|Rep: PREDICTED: similar to Malate
DeHydrogenase family member (mdh-1) - Tribolium
castaneum
Length = 374
Score = 115 bits (276), Expect = 2e-24
Identities = 79/314 (25%), Positives = 153/314 (48%), Gaps = 12/314 (3%)
Query: 28 VSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELSNLPGGPSVSAFIGDTN 87
V+++ S +GS ++L LK+N + +L L+D+++ +L+ + + +F +
Sbjct: 31 VTLLDTLSSVGSNLALLLKQNLDIYELRLFDEENNTNAFACDLNEIDTRTKLKSF-SCKS 89
Query: 88 LEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPIN 147
L+ AI +++V+ KPG+++ ++ N ++ + +A N EA I+ P+
Sbjct: 90 LKNAIVGAHVVISTGGCQEKPGSSQRELFDKNLDNVRNVAMFLAEFNPEAIYCIAKPPVE 149
Query: 148 YLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEIQVPVIGGHSDKTI 207
L+P S K Y+P K+ G+ + + + +F+A+ N ++ P+IGG S KT
Sbjct: 150 ALVPMVSEEYKKAETYDPRKIIGVATVASMIANTFIAEHTNQNPADVLCPIIGGLSPKTT 209
Query: 208 IPLFSNLTPRNYRIEPCQADMLTRLVRKAGTEVVMHKHGAESSTLAMAWSINEFIDIILD 267
IP+ S P N P L V G E ++ K + A+A I+ FI +++
Sbjct: 210 IPVLSQTKP-NVPFNPDLYKKLQEAVAH-GEETLLCKGAMFCYSKAVA--ISRFIHLVVK 265
Query: 268 AILGYR-VVVNCYTANSNFGTKFFAGPTSV---GPHGIIQACCHFP-MSEFESYLLNRCI 322
A+ G + V + + A + +F TS+ GP G+ A H P +++ E+ L
Sbjct: 266 ALKGEKHCVESAFVAQTGHIGEFLPYMTSIVKLGPQGV--ASTHMPKINDLETTRLRAAE 323
Query: 323 PILSREVLEGEKYV 336
P + +L G+ ++
Sbjct: 324 PHIVENILLGQTFI 337
>UniRef50_A7TSF5 Cluster: Putative uncharacterized protein; n=1;
Vanderwaltozyma polyspora DSM 70294|Rep: Putative
uncharacterized protein - Vanderwaltozyma polyspora DSM
70294
Length = 387
Score = 113 bits (273), Expect = 5e-24
Identities = 82/253 (32%), Positives = 133/253 (52%), Gaps = 23/253 (9%)
Query: 22 QKRNVQVSVIGAASDIGSYVSLFLK---RNSKVSKLHLYDDDDRIK---GTELELSNLPG 75
+ V+++VIGAA IG +SL L+ +N+ ++LHL D +K G +LS++
Sbjct: 37 KSNQVKITVIGAAGGIGQSLSLLLRTSLQNNNDNQLHLALFDVNMKVLNGVHADLSHVNT 96
Query: 76 GPSVSAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQ 135
+S NL ++ SNLV++ + +PRKPG TR+ + NA +I+ + + + +
Sbjct: 97 NMKLSLH---DNLRDSLVDSNLVIIPAGVPRKPGMTRDDLFNINAGIIKGIAQELNTIDS 153
Query: 136 EAFVAISTNPINYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEIQ 195
FV + +NP+N L+P +V+ + FGIT +D R+ +FV + +A
Sbjct: 154 TPFVLLISNPVNSLLPVLQSVLNDVYL---GRCFGITELDLVRASTFVNGFMDNSASSSN 210
Query: 196 ----VPVIGGHSDKTIIPLFSNLTPRN-----YRI--EPCQADMLTRLVRKAGTEVVMHK 244
VPVIGGHS TI+P+ SN + N Y + + L ++ G EVV K
Sbjct: 211 EMPYVPVIGGHSGDTILPVLSNCSFNNSTFSAYDLISDDVAIKKLVHRIQYGGDEVVQAK 270
Query: 245 HGAESSTLAMAWS 257
G S+TL+MA+S
Sbjct: 271 DGMGSATLSMAYS 283
>UniRef50_Q4Q3J5 Cluster: Malate dehydrogenase, putative; n=5;
Trypanosomatidae|Rep: Malate dehydrogenase, putative -
Leishmania major
Length = 342
Score = 103 bits (246), Expect = 9e-21
Identities = 84/320 (26%), Positives = 143/320 (44%), Gaps = 14/320 (4%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKL----HLYDDDDRIKGTELELSNLPGGPSVSAF 82
+V + G ++ +G +SL LK N V +L DDD G +LS++ P V
Sbjct: 16 KVVLFGCSNAVGQPLSLLLKMNPHVEELVCCNTAADDDVPGSGIAADLSHIDTLPKVHYA 75
Query: 83 IGDTNLEQAIHSSNLV-VMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAI 141
+ + + L+ V R+ L A AP ++R+ A+A+ + VA+
Sbjct: 76 TDEGQWPALLRDAQLILVCFGSSFDLLREDRDIALKAAAPTMRRVMAAVASSDTTGNVAV 135
Query: 142 STNPINYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEIQVPVIGG 201
++P+N L PF + ++ G ++P K+FG+T +D R+R VA L +N ++ VPV+GG
Sbjct: 136 VSSPVNALTPFCAELLKASGKFDPRKLFGVTTLDVIRTRKLVAGTLHMNPYDVNVPVVGG 195
Query: 202 HSDKTIIPLFSNLTPR-----NYRI--EPCQADMLTRLVRKAGTEVVMHKHGAESSTLAM 254
T PL + R RI E +L A + + A L +
Sbjct: 196 CGGVTACPLIAQTGLRIPLDDIVRISGEVQSYGVLFEAAVGADSHDALSTEVAPPVALGL 255
Query: 255 AWSINEFIDIILDAILGYRVVVNCYTANSNF--GTKFFAGPTSVGPHGIIQACCHFPMSE 312
A++ +F +L A+ G +V C S T FF+ +G G+ + ++
Sbjct: 256 AYAACDFSTSLLKALRGDVGIVECALVESTMRSETPFFSSRVELGREGVQRVFPMGALTS 315
Query: 313 FESYLLNRCIPILSREVLEG 332
+E L+ +P L R+V G
Sbjct: 316 YEHELIETAVPELMRDVQAG 335
>UniRef50_A3BMG8 Cluster: Putative uncharacterized protein; n=3;
Oryza sativa|Rep: Putative uncharacterized protein -
Oryza sativa subsp. japonica (Rice)
Length = 405
Score = 91.9 bits (218), Expect = 2e-17
Identities = 90/333 (27%), Positives = 146/333 (43%), Gaps = 17/333 (5%)
Query: 17 NTLILQKRNVQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELSNLPGG 76
N ++ Q +V+++GAA IG +SL +K + VS LHLYD + + G +L +
Sbjct: 69 NRVVAQAGGYKVAILGAAGGIGQPLSLLVKMSPLVSALHLYDIAN-VDGVTADLGHCNTP 127
Query: 77 PSVSAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQE 136
V+ F G L + ++VV+ + +PRKPG TR+ + G NA +++ L +A+A
Sbjct: 128 AKVAGFTGKEELAGCLAGVDVVVIPAGVPRKPGMTRDDLFGINAGIVRELVEAVADHAPA 187
Query: 137 AFVAISTNPINYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALK-INAQEIQ 195
A P G P++ H R+R V + + A+ +
Sbjct: 188 GAGARHLQPGELHRADRRRGAEAEGRVRPAEAVR-RHDAGRRARQHVRRGDEGPPARRRR 246
Query: 196 VPVIGGHSDKTIIPLFSNLTPR---NYRIEPCQADMLTRLVRKAGTEVV--MHKHGAESS 250
P G S T P S PR + + LTR ++ AGTEVV K G S+
Sbjct: 247 RP---GGSAATRRPPSSRCCPRRGPKTAFTDEEVEALTRRIQNAGTEVVEAKAKAGGGSA 303
Query: 251 TLAMAWSINEFIDIILDAILGYRVVVNCYTANSNFGTK--FFAGPTSVGPHGIIQACCHF 308
TL+MA++ F++ L + G V C + FFA +G G+ +
Sbjct: 304 TLSMAYAAARFLEASLRGLDGDADVYECSYVQCQAVPELPFFACRVKLGRDGVEEVAAAG 363
Query: 309 P----MSEFESYLLNRCIPILSREVLEGEKYVE 337
++EFE+ L P L + + +G Y +
Sbjct: 364 AELRGLTEFEARALEALKPQLKKSIDKGVAYAQ 396
>UniRef50_UPI00015B5ACF Cluster: PREDICTED: similar to
ENSANGP00000020184; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000020184 - Nasonia
vitripennis
Length = 352
Score = 89.4 bits (212), Expect = 1e-16
Identities = 79/322 (24%), Positives = 149/322 (46%), Gaps = 31/322 (9%)
Query: 24 RNVQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELSNLPG-------- 75
RN++V+++GA G ++L LK+++ + +L +YD +G LELS++
Sbjct: 34 RNLKVAIVGATGQTGRSLALCLKQSALIDELAVYDSHPT-RGLLLELSHMDSRCRTIVED 92
Query: 76 -GPSVSAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQN 134
+ SA G +LE+A+ + +V + + RE+ A ++++ +
Sbjct: 93 EASTTSACNGKRDLERALTGAKIVAITL----DGESIREE-----AEYLEKILSGLLGCC 143
Query: 135 QEAFVAISTNPINYLIPFASTVMYKYGCYNPS-KMFGITHIDTSRSRSFVAKALKINAQE 193
+A VA+ + +N L+P + + G + S ++FG+ + +R+ A+ LKI +
Sbjct: 144 PKALVALVSRRVNSLVPMLYELYKRAGLFEASSRIFGVVSLFATRANGLAAETLKIQPEL 203
Query: 194 IQVPVIGGHSDKTIIPLFSNLTPRNYRIEPCQADMLTRLVRKAGTEVVMHKHGAESSTLA 253
VPVIGG ++ +PLFS + PC AD + + +E + AESS+L
Sbjct: 204 SSVPVIGGGCPRSCVPLFS-------QTRPC-ADFTPEELSRL-SEAMKSAEAAESSSLC 254
Query: 254 MAWSINEFIDIILDAILGYRVVVNCYTANSNF--GTKFFAGPTSVGPHGIIQACCHFPMS 311
+ ++ F + A+ + C S K+ A P +GP G+ + +S
Sbjct: 255 LGFAAARFCISLCKALRAEPGLRECAYVRSCLVPELKYLAAPLELGPTGLQRELGVARIS 314
Query: 312 EFESYLLNRCIPILSREVLEGE 333
E L +P + R++ GE
Sbjct: 315 NAECQQLYLALPKIQRDIRLGE 336
>UniRef50_A2SSY4 Cluster: L-lactate dehydrogenase; n=3;
Methanomicrobiales|Rep: L-lactate dehydrogenase -
Methanocorpusculum labreanum (strain ATCC 43576 / DSM
4855 / Z)
Length = 319
Score = 85.4 bits (202), Expect = 2e-15
Identities = 55/202 (27%), Positives = 106/202 (52%), Gaps = 13/202 (6%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYD---DDDRIKGTELEL--SNLPGGPSVSA 81
+V++IGA +GSYV+ + + V ++ LY ++ + G ++ S G +
Sbjct: 3 KVTIIGATGQVGSYVAHAVSQFPHVQEMCLYGRPGNEQYLDGLAHDMMDSFAARGTNTRV 62
Query: 82 FIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAI 141
G T E + S+++V+ S +PRK TR + NA +++ + + EA + +
Sbjct: 63 TFGTTPKE--LRGSDIIVLTSGVPRKATQTRLDLALENARIVKVFAEQVGRMAPEAILLV 120
Query: 142 STNPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIG 200
TNP++ + +TV KY P ++FG+ TH+D+ R ++ +A+ ++ EI +IG
Sbjct: 121 VTNPVDIM----TTVALKYSGMMPHRVFGLGTHLDSMRLKACLAEFFNVHVSEIHTRIIG 176
Query: 201 GHSDKTIIPLFSNLTPRNYRIE 222
H D T++P++S T +I+
Sbjct: 177 EHGD-TMVPMWSATTVGGIQID 197
>UniRef50_UPI00015B4591 Cluster: PREDICTED: similar to mitochondrial
malate dehydrogenase; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to mitochondrial malate dehydrogenase
- Nasonia vitripennis
Length = 299
Score = 84.2 bits (199), Expect = 4e-15
Identities = 60/298 (20%), Positives = 140/298 (46%), Gaps = 9/298 (3%)
Query: 43 LFLKRNSKVSKLHLYDDDDRIKGTELELSNLPGGPSVSAFIGDTNLEQAIHSSNLVVMVS 102
+ LK+N + ++ L D D+ + ++ ++ ++ F ++ L+ + ++++V ++
Sbjct: 1 MLLKQNPAIKEIRLIDTDNSLMSPVCDMRHIDTSTTIRHFRKNSILD-GLRNTDIVALMD 59
Query: 103 RMPRKPGNTREQMLGANAP-LIQRLCKAIAAQNQEAFVAISTNPINYLIPFASTVMYKY- 160
GN M N+ ++ + + + +A VA+ T+P+ +P S + YKY
Sbjct: 60 ETDFMMGNKGPFMQFVNSSNYVKSVAECMINVCPKALVAVFTHPVTATLPLVSEI-YKYS 118
Query: 161 GCYNPSKMFGITHIDTSRSRSFVAKALKINAQEIQVPVIGGHSDKTIIPLFSNLTPRNYR 220
G ++P+++FG +++ R + A L +N I VP+ GG T++PL S P N
Sbjct: 119 GDWDPNRIFGSAALESMRISAMTATLLDLNPSFISVPIAGGIDSLTVVPLLSRARPFNSF 178
Query: 221 IEPCQADMLTRLVRKAGTEVVMHKHGAESSTLAMAWSINEFIDIILDAILGYRVVVNCYT 280
E + +L +R A ++ + + + TL+ + +FI +++ + + +
Sbjct: 179 TEENEC-LLIHQLRSA--DMKLFETETKGPTLSSGMAAAKFISTLINGMKKQSISITSAY 235
Query: 281 ANSNF--GTKFFAGPTSVGPHGIIQACCHFPMSEFESYLLNRCIPILSREVLEGEKYV 336
S+ ++ GP+G+ Q +S E ++ + P++++ V K++
Sbjct: 236 VRSDVLPSCQYMTSEIQFGPNGVQQNFGLPKVSPTEISMIGQAAPVINKIVKSAIKFL 293
>UniRef50_A7I5J9 Cluster: L-lactate dehydrogenase precursor; n=1;
Candidatus Methanoregula boonei 6A8|Rep: L-lactate
dehydrogenase precursor - Methanoregula boonei (strain
6A8)
Length = 332
Score = 84.2 bits (199), Expect = 4e-15
Identities = 55/228 (24%), Positives = 116/228 (50%), Gaps = 15/228 (6%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDR---IKGTELELSNLPGGPSVSAFI 83
+V++IGA ++G++ + + + V ++ LY + R +KG + ++ + +
Sbjct: 3 KVTIIGATGNVGTFAAYAVSVDPHVHEILLYGREGREAFLKGLAQDFADSFAARGTNIRV 62
Query: 84 GDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAIST 143
T + + S++VV+ + PR PG R + NA +I + + I + + + T
Sbjct: 63 TWTTSLKDVAGSDIVVITAGTPRGPGQNRLDLALGNARIIAPMARTIGTIAPDTKIIMVT 122
Query: 144 NPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGH 202
NP++ + + V KY P+++FG+ TH+D+ R +S +A K++ E+ +IG H
Sbjct: 123 NPVDVM----TCVALKYSGLKPNQVFGLGTHLDSMRLKSLIASYFKVHVSEVHTRIIGEH 178
Query: 203 SDKTIIPLFSNLTPRNYRIE--PCQADM----LTRLVRKAGTEVVMHK 244
D +++PL+S T +I P A + + V+ +G +++ +K
Sbjct: 179 GD-SMVPLWSATTIGGIKISNLPAFAHLPVQDFIQSVKTSGEQIIKNK 225
>UniRef50_UPI0000DB6C4F Cluster: PREDICTED: similar to Malate
DeHydrogenase family member (mdh-1); n=1; Apis
mellifera|Rep: PREDICTED: similar to Malate
DeHydrogenase family member (mdh-1) - Apis mellifera
Length = 221
Score = 83.8 bits (198), Expect = 6e-15
Identities = 58/219 (26%), Positives = 101/219 (46%), Gaps = 5/219 (2%)
Query: 126 LCKAIAAQNQEAFVAISTNPINYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAK 185
+ + +A N E+ VA+ P+ +P S + G ++P ++ G T +D R + A
Sbjct: 1 MAEQMAQFNSESLVAVFVRPVTATLPTVSEIYKLAGWWDPDRIIGSTALDRMRMEALTAN 60
Query: 186 ALKINAQEIQVPVIGGHSDKTIIPLFSNLTPRNYRIEPCQADMLTRLVRKAGTEVVMHKH 245
L +N + VP++GG TI+PL S TP N R Q DML + +R A E M
Sbjct: 61 LLDLNPAFLSVPLVGGADLNTIVPLLSCATPIN-RFTNAQQDMLLQSLRSADKE--MANI 117
Query: 246 GAESSTLAMAWSINEFIDIILDAILGYRVVVNCYTANSNF--GTKFFAGPTSVGPHGIIQ 303
+S TL+ + + I + + G++ + + SN ++F GP GI +
Sbjct: 118 ELKSPTLSDGAAAAKLILALAGGLSGFKNITSSAYVRSNVLPVCRYFTSELQFGPGGIQK 177
Query: 304 ACCHFPMSEFESYLLNRCIPILSREVLEGEKYVEFMENV 342
MS E L+ + IP +++ + K V + ++
Sbjct: 178 NFGLPKMSSTEIMLVEQAIPCINKCIGMATKAVHYNRHI 216
>UniRef50_A7I2F1 Cluster: Malate dehydrogenase; n=1; Campylobacter
hominis ATCC BAA-381|Rep: Malate dehydrogenase -
Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 /
NCTC 13146 /CH001A)
Length = 297
Score = 82.2 bits (194), Expect = 2e-14
Identities = 62/244 (25%), Positives = 122/244 (50%), Gaps = 9/244 (3%)
Query: 26 VQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDD-DDRIKGTELELSNLPGGPSVSAFIG 84
+++S+IGA + + VS L ++ ++S++ L D D K L+LS+L + I
Sbjct: 1 MKISIIGAGNIGSNIVSQLLCKDFEISQIALIDIFGDLAKARALDLSHLASVYNKKTEIS 60
Query: 85 DTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTN 144
++ E + +S++VV+ + R+ G +R +L NA +I K +A EA + + TN
Sbjct: 61 GSSDETLLKNSDIVVITAGKTRQAGQSRADLLNDNAKIISSCAKNVAKYAPEAIIILITN 120
Query: 145 PINYLIPFASTVMYKYGCYNPSKMFGIT-HIDTSRSRSFVAKALKINAQEIQVPVIGGHS 203
P++ L + V YK + K+ + +D++R R +AK+ +N +I+ V+G H+
Sbjct: 121 PVDTL----AFVAYKASGFKKEKIIAMAGELDSARLRYEIAKSENVNVTDIKASVVGAHN 176
Query: 204 DKTIIPLFSNLTPRNYRIEPCQADMLTRLVRKAGTEVVMHKHGAESSTLAMAWSINEFID 263
D+ I L + + +P ++ +G+++ + SS A A + ID
Sbjct: 177 DEMQI-LEDEIYKFGKKFKPQNLSLIKENTINSGSKITALQ--KTSSFFAPAACSVKMID 233
Query: 264 IILD 267
I++
Sbjct: 234 AIIN 237
>UniRef50_Q7M9A7 Cluster: Malate dehydrogenase; n=4;
Epsilonproteobacteria|Rep: Malate dehydrogenase -
Wolinella succinogenes
Length = 314
Score = 81.4 bits (192), Expect = 3e-14
Identities = 63/245 (25%), Positives = 120/245 (48%), Gaps = 13/245 (5%)
Query: 28 VSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDD-DRIKGTELELSNLPGGPSVSAFIGDT 86
+ +IGA +GS V+ L ++ + D + D +G L++ + +
Sbjct: 1 MGIIGAGH-VGSTVAFILATQGICQEIIIKDLNLDTARGIALDMGHAASATKTHTIVRVA 59
Query: 87 NLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPI 146
N + ++VV + PR+PG +R+ +L ANA +I+ + + QE+ + + +NP+
Sbjct: 60 NEPSDLRGCDVVVFCAGSPRQPGMSRDDLLLANAKVIRTVLSEVKPYIQESVLVMVSNPL 119
Query: 147 NYLIPFASTVMYKYGCYNPSKMFGITHI-DTSRSRSFVAKALKINAQEIQVPVIGGHSDK 205
+ ++ A K +P ++ G+ I D++R SF+ + L + +I V+GGH D
Sbjct: 120 DAMVYTA----IKESGLSPLQVLGMAGILDSARMASFIFEKLGYGSDQIVASVMGGHGDD 175
Query: 206 TI-IPLFSNL--TPRNYRIEPCQADMLTRLVRKAGTEVVMH-KHGAESSTLAMAWSINEF 261
+ +P +SN+ P +EP + + + R AG E+V + K G S+ A A S
Sbjct: 176 MVPLPRYSNVAGVPITELLEPQEIEEIIHRTRNAGAEIVGYLKKG--SAYFAPAKSTAIM 233
Query: 262 IDIIL 266
++ IL
Sbjct: 234 VEAIL 238
>UniRef50_Q979N9 Cluster: Malate dehydrogenase; n=4;
Thermoplasmatales|Rep: Malate dehydrogenase -
Thermoplasma volcanium
Length = 325
Score = 81.0 bits (191), Expect = 4e-14
Identities = 70/292 (23%), Positives = 138/292 (47%), Gaps = 27/292 (9%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRI-KGTELELSNLPGGPS------- 78
++SVIGA + +G+ V+ FL ++ ++L+D D I +G L++ G P
Sbjct: 5 KISVIGAGN-VGATVAQFLA-TKELGDVYLFDVVDGIPEGKALDIQE--GAPHWGYDLDV 60
Query: 79 VSAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAF 138
V D++ + + S+++V+ + M RKPG +RE + N +I + K I + ++
Sbjct: 61 VGFSTSDSSNYKNMEGSDVIVVTAGMARKPGMSREDLFDKNVEIIADVSKNIKKYSPDSI 120
Query: 139 VAISTNPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVP 197
+ + +NP + + + + K +P ++ G+ +D+SR R+F+AK L ++ +++
Sbjct: 121 IVVVSNPADIM----AYALQKISGVDPQRIMGLGGSLDSSRFRTFLAKELDVSVEDVNAF 176
Query: 198 VIGGHSDKTIIPLFSNLTPRNYRIEPC----QADMLTRLVRKAGTEVVMHKHGAESSTLA 253
VIGGH D ++P + IE + D + + R G E+V + A S+ A
Sbjct: 177 VIGGHGD-DMVPFIRYSSVAGIPIEKLLPKEKIDAIVKRTRFGGGEIVNYLK-AGSAYYA 234
Query: 254 MAWSINEFIDIILD----AILGYRVVVNCYTANSNFGTKFFAGPTSVGPHGI 301
SI ++ ++ I + + + KF P +G G+
Sbjct: 235 PGISITAMVESVIKDKKRVIPCAAYITGKHAEHYGINNKFIGVPIKIGERGV 286
>UniRef50_Q3J7E7 Cluster: Malate dehydrogenase; n=5;
Gammaproteobacteria|Rep: Malate dehydrogenase -
Nitrosococcus oceani (strain ATCC 19707 / NCIMB 11848)
Length = 311
Score = 81.0 bits (191), Expect = 4e-14
Identities = 65/246 (26%), Positives = 124/246 (50%), Gaps = 15/246 (6%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRI-KGTELELS-NLPGGPSVSAFIG 84
+++++GA +G + FL +N +L L D + + +G L++ + P + G
Sbjct: 5 KITIVGAGR-VGEATAQFLVKNELCRELVLLDAQEGVAQGAALDIQQSAPLFDFDARVTG 63
Query: 85 DTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTN 144
TN E I S+LVV+ + PRKPG +R +L +N P+I + + ++ V I TN
Sbjct: 64 STNYE-LIADSDLVVITAGKPRKPGMSRSDVLDSNLPIITDIMNNVMRFAPQSLVMIVTN 122
Query: 145 PINYLIPFASTVMYKYGCYNPSKMFGITHI-DTSRSRSFVAKALKINAQEIQVPVIGGHS 203
P++ L A +++ ++ +++FG + D++R SF+A ++ ++I V+GGH
Sbjct: 123 PVDVLTYHA----WRHCGWDRARVFGQAGVLDSARMASFIAGETGLSVKDISAMVLGGHG 178
Query: 204 DKTIIPLFSNLT----PRNYRIEPCQADMLTRLVRKAGTEVVMHKHGAESSTLAMAWSIN 259
D T++PL T P + ++ + + R G E++ + S+ A A +I
Sbjct: 179 D-TMLPLIRYTTISGIPLTHFLDQQVIEKIIERTRHGGFEILRLRQ-TSSAYDAPAAAIA 236
Query: 260 EFIDII 265
+D I
Sbjct: 237 GMVDAI 242
>UniRef50_A7GYI6 Cluster: Lactate/malate dehydrogenase, NAD binding
domain protein; n=2; Campylobacter|Rep: Lactate/malate
dehydrogenase, NAD binding domain protein -
Campylobacter curvus 525.92
Length = 297
Score = 80.2 bits (189), Expect = 7e-14
Identities = 60/220 (27%), Positives = 115/220 (52%), Gaps = 15/220 (6%)
Query: 26 VQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYD---DDDRIKGTELELSNLPGGPSVSAF 82
+++SVIGA + +G+ ++ L ++ L D D R K ++ + +S
Sbjct: 1 MKISVIGAGN-VGASIAYALAMRGVCDEIALVDIFGDVARAKAIDIAQAGCVFCGCLSTA 59
Query: 83 IGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAIS 142
GD I +S++VV+ + PRK G TRE +L NA ++++ + IA A V I
Sbjct: 60 GGDDFA--LIEASDIVVVTAGSPRKEGQTREDLLLKNAQVVKQTAQNIAKFAPNAIVIIV 117
Query: 143 TNPINYLIPFASTVMYKYGCYNPSKMFGIT-HIDTSRSRSFVAKALKINAQEIQVPVIGG 201
TNP++ ++ TV+ +Y ++ S++ G+ +D++R R +A I+A+++ V+G
Sbjct: 118 TNPLDVMV---WTVL-RYSGFDRSRVIGMAGELDSARCRYEIASLKDISAKDVSAKVLGA 173
Query: 202 HSDKTIIPLFSNLTPRNYRIEPCQADMLTRLVRKAGTEVV 241
H+DK I+ NL N + P + + + + + G ++V
Sbjct: 174 HNDKMIVSA-KNL---NQNLSPLELEKIKQETKTGGAKIV 209
>UniRef50_O26290 Cluster: Malate dehydrogenase; n=2;
Methanobacteriaceae|Rep: Malate dehydrogenase -
Methanobacterium thermoautotrophicum
Length = 325
Score = 80.2 bits (189), Expect = 7e-14
Identities = 48/201 (23%), Positives = 103/201 (51%), Gaps = 9/201 (4%)
Query: 26 VQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIK---GTELELSNLPGGPSVSAF 82
++VS+IG+ +G +L L V LHL + ++ G L++S+ VS
Sbjct: 1 MKVSIIGSTGRVGRATALCLAEEEAVKTLHLISRKESLEQNLGEVLDMSDALAAKGVSVK 60
Query: 83 IGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAIS 142
+ ++ + ++ S +VV+ + +PR R+ + N ++ + IA ++ + +
Sbjct: 61 LENSADIENVYGSRIVVITAGVPRTADMDRDDLAFKNGRIVADYARQIARFAPDSIILVV 120
Query: 143 TNPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGG 201
TNP++ + + V +Y ++PS++FG+ H+D+ R ++++A+ ++ E+ VIG
Sbjct: 121 TNPVDVM----TYVALRYSGFHPSRVFGLGNHLDSLRLKNYMARHFNVHVSEVHTRVIGQ 176
Query: 202 HSDKTIIPLFSNLTPRNYRIE 222
H ++PL S+ + IE
Sbjct: 177 HG-PYMVPLISSTSIGGIPIE 196
>UniRef50_Q64P62 Cluster: Malate dehydrogenase; n=28;
Bacteroidetes|Rep: Malate dehydrogenase - Bacteroides
fragilis
Length = 313
Score = 80.2 bits (189), Expect = 7e-14
Identities = 52/187 (27%), Positives = 105/187 (56%), Gaps = 8/187 (4%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRI-KGTELELSNLPGGPSV-SAFIG 84
+V+V+GA + +G+ + L N ++ + D + + +G +++ + +G
Sbjct: 3 KVTVVGAGN-VGATCANVLAFNEVADEVVMLDVKEGVSEGKAMDMMQTAQLLGFDTTIVG 61
Query: 85 DTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTN 144
TN +S++VV+ S +PRKPG TRE+++G NA +++ + + + + A + + +N
Sbjct: 62 CTNDYAQTANSDVVVITSGIPRKPGMTREELIGVNAGIVKSVAENLLKYSPNAIIVVISN 121
Query: 145 PINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHS 203
P++ + A + G +++ G+ +D+SR + F+++AL NA E++ VIGGH
Sbjct: 122 PMDTMTYLA---LKSLG-LPKNRVIGMGGALDSSRFKYFLSQALGCNANEVEGMVIGGHG 177
Query: 204 DKTIIPL 210
D T+IPL
Sbjct: 178 DTTMIPL 184
>UniRef50_Q8TWG5 Cluster: Malate dehydrogenase; n=2;
Euryarchaeota|Rep: Malate dehydrogenase - Methanopyrus
kandleri
Length = 317
Score = 79.8 bits (188), Expect = 1e-13
Identities = 52/191 (27%), Positives = 98/191 (51%), Gaps = 9/191 (4%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLY---DDDDRIKGTELELSNLPGGPSVSAFI 83
+V+VIGA +GS + L V+++ L D+++G ++ + A I
Sbjct: 3 KVAVIGATGRVGSTAAARLALLDCVNEVTLIARPKSVDKLRGLRRDILDSLAAAQKDAEI 62
Query: 84 GDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAIST 143
++++VM + +PRKPG TR + NA +I++ + +A +N EA V + T
Sbjct: 63 TIGCERDDYVDADVIVMTAGIPRKPGQTRLDLTKDNAAIIKKYLEGVAEENPEAIVLVVT 122
Query: 144 NPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGH 202
NP++ L + V K +++ G+ TH+D+ R + +AK ++ E+ +IG H
Sbjct: 123 NPVDVL----TYVALKVSGLPKNRVIGLGTHLDSMRFKVLIAKHFNVHMSEVHTRIIGEH 178
Query: 203 SDKTIIPLFSN 213
D T++P+ S+
Sbjct: 179 GD-TMVPVISS 188
>UniRef50_Q6VVP7 Cluster: Malate dehydrogenase; n=6; Plasmodium|Rep:
Malate dehydrogenase - Plasmodium falciparum
Length = 313
Score = 78.2 bits (184), Expect = 3e-13
Identities = 55/187 (29%), Positives = 103/187 (55%), Gaps = 11/187 (5%)
Query: 27 QVSVIGAASDIGSYVS-LFLKRNSKVSKLHLYDDDDRI-KGTELELSNLPGGPSVSAFIG 84
++++IG+ IG+ V L L N + L LYD I +G L+L + V+ I
Sbjct: 3 KIALIGSGQ-IGAIVGELCLLEN--LGDLILYDVVPGIPQGKALDLKHFSTILGVNRNIL 59
Query: 85 DTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTN 144
TN + I ++++V+ + + RK G TRE ++G N +++ + +++ +AFV +N
Sbjct: 60 GTNQIEDIKDADIIVITAGVQRKEGMTREDLIGVNGKIMKSVAESVKLHCSKAFVICVSN 119
Query: 145 PINYLIPFASTVMYKYGCYNPSKMFGITHI-DTSRSRSFVAKALKINAQEIQVPVIGGHS 203
P++ ++ V +K+ K+ G+ I DTSR S +A LK++A+++ ++GGH
Sbjct: 120 PLDIMV----NVFHKFSNLPHEKICGMAGILDTSRYCSLIADKLKVSAEDVNAVILGGHG 175
Query: 204 DKTIIPL 210
D ++PL
Sbjct: 176 D-LMVPL 181
>UniRef50_UPI0000D56DC5 Cluster: PREDICTED: similar to Malate
dehydrogenase, mitochondrial precursor; n=1; Tribolium
castaneum|Rep: PREDICTED: similar to Malate
dehydrogenase, mitochondrial precursor - Tribolium
castaneum
Length = 349
Score = 77.4 bits (182), Expect = 5e-13
Identities = 53/268 (19%), Positives = 119/268 (44%), Gaps = 4/268 (1%)
Query: 12 TQLKKNTLILQKRNVQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELS 71
T+ ++ +++VQV ++GA + +G ++ +K+N +S LHL +++ L+ +
Sbjct: 8 TKFSRHFCSKPQKHVQVCILGADTLLGQSLAFLIKQNPAISGLHL-QGTSKVESMALDFN 66
Query: 72 NLPGGPSVSAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIA 131
+ V ++ ++ +++ +++VVM+ + +++ A + +L + A
Sbjct: 67 HFDTRCRVHSYYDMDSVSKSVKCADIVVMLGLNTSTSKMSIPKLVMAEGVRVAKLAETCA 126
Query: 132 AQNQEAFVAISTNPINYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINA 191
+A + ++ PI+ +P + V + Y+P ++ G + ++ + ++
Sbjct: 127 KYAPKAVIVVAVTPISVTLPIVAEVYKQSDWYHPGRLLGSAALAEVKANAIAGHYQTLDP 186
Query: 192 QEIQVPVIGGHSDKTIIPLFSNLTPRNYRIEPCQADMLTRLVRKAGTEVVM-HKHGAESS 250
Q + VP++GG IPLFS P I D L RK + M H G
Sbjct: 187 QMVHVPIVGGPDLDCAIPLFSQTQP--VGIAQKDTDKLVEEFRKEIPQPAMSHAVGLNRM 244
Query: 251 TLAMAWSINEFIDIILDAILGYRVVVNC 278
+A IN + + A + ++ C
Sbjct: 245 ITGIATGINGDYNANVLAFVRTNIIKTC 272
>UniRef50_P16115 Cluster: L-lactate dehydrogenase; n=4;
Thermotogaceae|Rep: L-lactate dehydrogenase - Thermotoga
maritima
Length = 319
Score = 77.4 bits (182), Expect = 5e-13
Identities = 77/320 (24%), Positives = 146/320 (45%), Gaps = 28/320 (8%)
Query: 26 VQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYD-DDDRIKGTELELSN-LPGGPSVSAFI 83
+++ ++G +GS + L ++ L D D R +G L+L + P + +
Sbjct: 1 MKIGIVGLGR-VGSSTAFALLMKGFAREMVLIDVDKKRAEGDALDLIHGTPFTRRANIYA 59
Query: 84 GDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAIST 143
GD + S++V++ + +P+KPG TR Q+LG NA +++ + + ++ ++ V + T
Sbjct: 60 GDY---ADLKGSDVVIVAAGVPQKPGETRLQLLGRNARVMKEIARNVSKYAPDSIVIVVT 116
Query: 144 NPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGH 202
NP++ L F K +P K+FG T +DT+R R+ +A+ + + + V VIG H
Sbjct: 117 NPVDVLTYF----FLKESGMDPRKVFGSGTVLDTARLRTLIAQHCGFSPRSVHVYVIGEH 172
Query: 203 SDKTIIPLFSNL----TPRNYRIEPCQ------ADMLTRLVRKAGTEVVMHKHGAESSTL 252
D +P++S P + CQ + ++A E++ K GA +
Sbjct: 173 GDSE-VPVWSGAMIGGIPLQNMCQICQKCDSKILENFAEKTKRAAYEIIERK-GATHYAI 230
Query: 253 AMAWS-INEFIDIILDAILGYRVVVNCYTANSNFGTKFFAGPTSVGPHGIIQACCHFPMS 311
A+A + I E I +L V + Y + + P ++G HG ++ ++
Sbjct: 231 ALAVADIVESIFFDEKRVLTLSVYLEDYLGVKDL---CISVPVTLGKHG-VERILELNLN 286
Query: 312 EFESYLLNRCIPILSREVLE 331
E E + IL + E
Sbjct: 287 EEELEAFRKSASILKNAINE 306
>UniRef50_A3EWH3 Cluster: Malate/lactate dehydrogenase; n=1;
Leptospirillum sp. Group II UBA|Rep: Malate/lactate
dehydrogenase - Leptospirillum sp. Group II UBA
Length = 320
Score = 75.8 bits (178), Expect = 2e-12
Identities = 77/308 (25%), Positives = 146/308 (47%), Gaps = 23/308 (7%)
Query: 23 KRNVQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELSNLPGGPSV--- 79
++ +VS++GA + +G+ + + N + L + +G L++ L GP +
Sbjct: 4 RKRRKVSIVGAGN-VGATTAQKIVENGLADVVILDVREGMAQGKALDI--LESGPLLGFD 60
Query: 80 SAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFV 139
+ +G N E I S++VV+ + RKPG +RE +L N ++ + + I ++ V
Sbjct: 61 TRIVGSGNYE-TIEGSSVVVVTAGFSRKPGMSREDLLHKNGDIMIEVAEKIRKHAPDSVV 119
Query: 140 AISTNPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPV 198
+ TNP++ + + +++K + ++ G+ +D+SR FV++ + IQ V
Sbjct: 120 IMVTNPMDLM----AYILWKVTGFPRERVIGMGGALDSSRFAYFVSEVTNTSVSNIQTMV 175
Query: 199 IGGHSDKTIIPLFSNLTPRNYRIEPC-QADMLTRLV---RKAGTEVVMHKHGAESSTLAM 254
+GGH D ++PL T ++ D+L +LV R G E+V + S+ A
Sbjct: 176 MGGHGD-DMVPLLEFSTIAGVSLKKALDPDVLQKLVARTRDGGGEIVRLMKDS-SAYFAP 233
Query: 255 AWSINEFIDIILDAILGYRVVVNCYTANSNFGTK-FFAG-PTSVGPHGIIQACCHFPMSE 312
A +I I+ IL +RV+ + +G K F+G P +G G ++ P+S
Sbjct: 234 AAAIYSMIESILHD--RHRVIPSSVYLEGEYGVKGVFSGVPVQIGNIG-LEKIVLLPLSA 290
Query: 313 FESYLLNR 320
E +R
Sbjct: 291 EEEEAFHR 298
>UniRef50_Q7NHJ3 Cluster: Malate dehydrogenase; n=13; cellular
organisms|Rep: Malate dehydrogenase - Gloeobacter
violaceus
Length = 325
Score = 75.8 bits (178), Expect = 2e-12
Identities = 55/222 (24%), Positives = 110/222 (49%), Gaps = 9/222 (4%)
Query: 24 RNVQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELSNLPGGPSVSAFI 83
R +VS++GA + +GS ++ L + + + L + R +G L+L G + I
Sbjct: 7 RESKVSILGAGN-VGSALAQRLIQGNVADVVLLDIVEGRPQGITLDLLEACGVEGHTCRI 65
Query: 84 GDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAIST 143
TN S+++V+ + R+PG +R+ +L N ++ + + A + EA V + T
Sbjct: 66 TGTNDYAQTAGSDVLVVAAGFARQPGMSRDDLLLTNTRIVFEVTQKAVAHSPEATVVVVT 125
Query: 144 NPINYLIPFASTVMYKYGCYNPSKMFGITHI-DTSRSRSFVAKALKINAQEIQVPVIGGH 202
NP++ + S V ++ P ++ G+ + D +R +F+A L + ++I+ V+GGH
Sbjct: 126 NPLDAM----SHVAWRASGLVPERVMGMAGVLDAARFETFIAWELGFSVRDIRAMVLGGH 181
Query: 203 SDKTI-IPLFSNLT--PRNYRIEPCQADMLTRLVRKAGTEVV 241
D + +P ++ ++ P + + D L R G E+V
Sbjct: 182 GDLMVPLPRYTTISGVPLTQLLSSARIDALIERTRTGGAEIV 223
>UniRef50_O67655 Cluster: Malate dehydrogenase 1; n=3; Bacteria|Rep:
Malate dehydrogenase 1 - Aquifex aeolicus
Length = 335
Score = 74.9 bits (176), Expect = 3e-12
Identities = 83/330 (25%), Positives = 160/330 (48%), Gaps = 35/330 (10%)
Query: 28 VSVIGAASDIGSYVS--LFLKRNSKVSKLHLYDDDDR-----IKGTELELSNLPGGPSVS 80
V+VIGA + +G +V+ + LK + V L + +KG L++ + +
Sbjct: 7 VAVIGAGN-VGEHVASLILLKNLANVKMFDLPRKTEEKVFEPVKGKALDMKQMLAAMDID 65
Query: 81 AFIGDTNLE------QAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQN 134
A + + + + S++VV+ + PR+PG +RE +L AN +I + I
Sbjct: 66 ARVEGYTVTPEGEGYEPLEGSDIVVITAGFPRRPGMSREDLLEANIRIISVIADRIKRYA 125
Query: 135 QEAFVAISTNPINYLIPFASTVMYKYGCYNPSKMFGITHI-DTSRSRSFVAKALKINAQE 193
+A V + TNP++ + + V YK + +++ G+ + D++R ++F+++ L ++ ++
Sbjct: 126 PDAIVIVVTNPVDVM----TYVAYKLLNFPKNRVMGMAGVLDSARFKTFISEELMVSPKD 181
Query: 194 IQVPVIGGHSDKTIIPL--FSNL--TPRNYRIEPCQADMLTRLVRKAGTEVVMHKHGAES 249
I VIGGH D+ ++PL SN+ P + + + + R G E+V + G S
Sbjct: 182 IHAYVIGGHGDE-MVPLISISNVGGIPLKDLLPKEKLEKIIERTRFGGGEIV-NLMGT-S 238
Query: 250 STLAMAWSINEFIDIILD---AILGYRVVVNCYTANSNFGTK-FFAG-PTSVGPHGIIQA 304
+ A A +I + I+ ++ IL V ++ A +G + F G P +G +G ++
Sbjct: 239 AYYAPAAAIVDMIEALVQNSKRILPCSVYLD-GEAGEYYGVQGFCVGVPVKLGSNG-VEE 296
Query: 305 CCHFPMSEFESYLLNRCIPILSR--EVLEG 332
PM E E + R + + + EV EG
Sbjct: 297 IIKVPMIEEEREMWRRSVESVKKTVEVAEG 326
>UniRef50_P22988 Cluster: L-lactate dehydrogenase A; n=19;
Magnoliophyta|Rep: L-lactate dehydrogenase A - Hordeum
vulgare (Barley)
Length = 356
Score = 74.1 bits (174), Expect = 5e-12
Identities = 49/194 (25%), Positives = 105/194 (54%), Gaps = 11/194 (5%)
Query: 17 NTLILQKRNVQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDD-DDRIKGTELELSNLPG 75
++ + +R ++SVIGA + +G ++ + + ++ L D D+++G L+L +
Sbjct: 35 SSAVPHRRLTKISVIGAGN-VGMAIAQTILTQNLADEIALVDALPDKLRGEALDLQHAAA 93
Query: 76 G-PSVSAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQN 134
P V D + + +S+LV++ + + PG TR +L N L +++ +A +
Sbjct: 94 FLPRVRISGTDAAVTK---NSDLVIVTAGARQIPGETRLNLLQRNVALYRKIVPPVAEHS 150
Query: 135 QEAFVAISTNPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQE 193
+A + + +NP++ L + V +K + S++ G T++D+SR R +A+ L +NAQ+
Sbjct: 151 PDALLLVVSNPVDVL----TYVAWKLSGFPASRVIGSGTNLDSSRFRFLIAEHLDVNAQD 206
Query: 194 IQVPVIGGHSDKTI 207
+Q ++G H D ++
Sbjct: 207 VQAYMVGEHGDSSV 220
>UniRef50_UPI00005A0834 Cluster: PREDICTED: similar to Malate
dehydrogenase, mitochondrial precursor; n=1; Canis lupus
familiaris|Rep: PREDICTED: similar to Malate
dehydrogenase, mitochondrial precursor - Canis
familiaris
Length = 245
Score = 72.9 bits (171), Expect = 1e-11
Identities = 31/81 (38%), Positives = 50/81 (61%)
Query: 105 PRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPINYLIPFASTVMYKYGCYN 164
PRKPG TR+ + NA ++ A A EA + + +NP+N IP A+ V K+G Y+
Sbjct: 61 PRKPGMTRDDLFNTNASVVATPTAACAQHCPEAMICVISNPVNSTIPIATEVFKKHGAYD 120
Query: 165 PSKMFGITHIDTSRSRSFVAK 185
P+K+F +T +D R+ +F+A+
Sbjct: 121 PNKIFRVTTLDIVRANTFIAE 141
>UniRef50_Q86S07 Cluster: NAD-specific malate dehydrogenase 2; n=1;
Entamoeba histolytica|Rep: NAD-specific malate
dehydrogenase 2 - Entamoeba histolytica
Length = 329
Score = 72.9 bits (171), Expect = 1e-11
Identities = 63/242 (26%), Positives = 113/242 (46%), Gaps = 18/242 (7%)
Query: 26 VQVSVIGAASDIGSYVSLFLKRNSKVSK---LHLYD-DDDRIKGTELELSNLPGGPSVSA 81
+ V + GAA IG + + R LHLYD +D +KG +EL++ P +
Sbjct: 16 LHVLITGAAGQIGYNLCFLIGRGFLFDCDVILHLYDLNDMALKGLSMELTDCCL-PKLKG 74
Query: 82 FIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAA-QNQEAFVA 140
I T + A + ++ ++V+ +PRKPG R ++ N +++ KA+ N++ V
Sbjct: 75 IISTTEIALAFSNVDVAIIVAGVPRKPGMQRSDLINVNKKVMEMNGKALGTYSNKDVRVV 134
Query: 141 ISTNPINYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEIQVPVIG 200
+ NP N + V+ K P + +T +D +R+ +FVA + + + ++
Sbjct: 135 VVANPAN----TNAYVICKTSGIPPEHITALTRLDQNRATAFVANEVGCQPEFVHNIIVW 190
Query: 201 GHSDKTIIP--LFSNLTPRNYRIEP---C--QADMLTRLVRKAGTEVVMHKHGAESSTLA 253
G+ T+ P +S L +N I+P C D T VR G EV+ + + + + A
Sbjct: 191 GNHSNTMQPDLSYSYLADQN-GIKPLANCIEDFDAFTEKVRCRGEEVISTRKASSAGSAA 249
Query: 254 MA 255
A
Sbjct: 250 HA 251
>UniRef50_A6Q7S2 Cluster: Malate dehydrogenase, NAD-dependent; n=1;
Sulfurovum sp. NBC37-1|Rep: Malate dehydrogenase,
NAD-dependent - Sulfurovum sp. (strain NBC37-1)
Length = 320
Score = 72.5 bits (170), Expect = 1e-11
Identities = 62/245 (25%), Positives = 115/245 (46%), Gaps = 11/245 (4%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDD-DRIKGTELELSNLPGGPSVSAFIGD 85
+V+VIG + GS V+ L N + L + D KG L++S +
Sbjct: 6 KVTVIGTGN-FGSTVAFILAMNGSCHHVMLRGRNYDVAKGKALDMSQAANAARQHTIVKA 64
Query: 86 TNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNP 145
+ + S++V++ + PR PG +R+ +L NA +++ + I +A V + +NP
Sbjct: 65 AKGPEDMEGSDVVIITAGAPRTPGMSRDDLLFKNADIVKCYSREIKEYAPDAIVIVVSNP 124
Query: 146 INYLIPFASTVMYKYGCYNPSKMFGITHI-DTSRSRSFVAKALKINAQEIQVPVIGGHSD 204
++ + + V K + ++ G+ I D +R F+ + L+ A +I+ V+GGH D
Sbjct: 125 LDVM----TYVALKETGFPRQRVLGMAGILDAARMAHFIYEKLEYGAGQIRATVMGGHGD 180
Query: 205 KTIIPLFSNLTPRNYRIEP-CQADMLTRLVRKA--GTEVVMHKHGAESSTLAMAWSINEF 261
T++PL T IE ++ + +VRK G +++ G S+ A A S
Sbjct: 181 -TMVPLPKFTTVAGVPIEDLLDSEEIGEIVRKTRNGGAEIVNLLGDGSAYYAPAKSTTVM 239
Query: 262 IDIIL 266
++ IL
Sbjct: 240 VEAIL 244
>UniRef50_Q7VFV4 Cluster: Malate dehydrogenase; n=1; Helicobacter
hepaticus|Rep: Malate dehydrogenase - Helicobacter
hepaticus
Length = 315
Score = 72.1 bits (169), Expect = 2e-11
Identities = 63/299 (21%), Positives = 134/299 (44%), Gaps = 13/299 (4%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDD-DRIKGTELELSNLPGGPSVSAFIGD 85
++++IG + ++GS+++ ++ L+ +D R KG L++S + I
Sbjct: 4 KIAIIGGSGNVGSHIAFLGAMRHIAKEILLFSNDIPRCKGVGLDISQAAAIFDIPILIKG 63
Query: 86 TNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNP 145
N + I S +V++ + PR P TR +L NA +IQ + +A ++ + + +NP
Sbjct: 64 CNSYEEIAESEVVIITAGFPRTPNMTRNDLLLKNASIIQEISSNVARIAPQSLLIVVSNP 123
Query: 146 INYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKIN-AQEIQVPVIGGHSD 204
++ + V ++ + ++ G+ I S ++ +K + + + IQ VIG HSD
Sbjct: 124 LDAM----CLVAKQWSKFEKERVIGMAGILDSARLTYESKVMLGDFNKHIQSYVIGSHSD 179
Query: 205 KTIIPLFSNLTPRNYRIEPCQADMLTRLVR--KAGTEVVMHKHGAESSTLAMAWSINEFI 262
+ L L + M L++ K G +++ + S+ A A + + +
Sbjct: 180 DMLPLLRHCLCEGKVFTDIFTPKMQEELIKETKGGGAKIVNYYQKGSAYFAPASGVIKIL 239
Query: 263 DIILDAILGYRVVVNCYTANSNFGTK--FFAGPTSVGPHGIIQACCHFPMSEFESYLLN 319
+ I + L ++V +G K + P +G G ++ P+++ E +LN
Sbjct: 240 EAI--STLNEEILVCSVFTEGEYGIKDIYLGLPIKLGKKG-VEHIVELPLNQQEQEMLN 295
>UniRef50_A4A2L6 Cluster: L-lactate dehydrogenase; n=4;
Bacteria|Rep: L-lactate dehydrogenase - Blastopirellula
marina DSM 3645
Length = 313
Score = 71.3 bits (167), Expect = 3e-11
Identities = 71/288 (24%), Positives = 139/288 (48%), Gaps = 24/288 (8%)
Query: 26 VQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYD-DDDRIKGTELELSNLPGGPSVSAFIG 84
++VS+IG +GS + L+ ++ L D + D G L+L L G PSV+ +
Sbjct: 1 MKVSIIGGGGLVGSCAAFALQCGGIAREIALLDLNADLAGGHALDL--LHGAPSVADQVI 58
Query: 85 DTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAI--AAQNQEAFVAIS 142
+ + I S+++ + + + RKP +R ++ N L + ++ A ++A +
Sbjct: 59 TSGGYEHIPDSDVICITAGLRRKPDESRLDLINRNVDLFLSILDSVKSAGVKKDAICFVV 118
Query: 143 TNPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGG 201
+NP++ L A+ + S++ G+ T +DT R R+ +A+ +K+ +++ ++G
Sbjct: 119 SNPVDILTYLAAQRLN----LPTSRVIGLGTQLDTIRFRALIAQEMKLPPTQVKALILGE 174
Query: 202 HSDKTIIPLFSNLTPRNYRIE------PCQADMLTRLVRKAGTEVVMHKHGAESSTLAMA 255
H D +++P++S T ++ P +A L R +G EV+ K GA A+
Sbjct: 175 HGD-SMLPVWSAATVNGLPLDKFPGWTPNKATELFTRTRGSGAEVIKKKGGA---GFAVG 230
Query: 256 WSINEFIDIILDAILGYRVVVNCYTANSNFGTKFFA--GPTSVGPHGI 301
+I + I+ I A+ +V+ N +G + A PT VG G+
Sbjct: 231 IAIRDVIEAI--ALDKNQVLPVSSVQNGCYGIRNVALSVPTLVGRDGV 276
>UniRef50_A7U552 Cluster: Mitochondrial malate-dehydrogenase; n=2;
Toxoplasma gondii|Rep: Mitochondrial
malate-dehydrogenase - Toxoplasma gondii
Length = 470
Score = 71.3 bits (167), Expect = 3e-11
Identities = 50/186 (26%), Positives = 102/186 (54%), Gaps = 9/186 (4%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDD-DDRIKGTELELSNLPGGPSVSAFIGD 85
++ +IG + IG+ ++L L ++ + ++D D +G L+L L V
Sbjct: 159 KIGLIGGGN-IGATLAL-LSAVKELGDVVMFDVVQDLPQGKCLDLYQLTPISGVDVRFEG 216
Query: 86 TNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNP 145
+N + ++++++ + +PRKPG +R+ +L NA ++ ++ +AI AFV TNP
Sbjct: 217 SNDYSVLKDADVIIVTAGVPRKPGMSRDDLLAINAKIMGQVGEAIKQYCPNAFVICITNP 276
Query: 146 INYLIPFASTVMYKYGCYNPSKMFGITHI-DTSRSRSFVAKALKINAQEIQVPVIGGHSD 204
++ ++ + K G P K+ G+ + D++R R+F+++ L ++ +I V+GGH D
Sbjct: 277 LDVMV---YILREKCG-LPPHKVCGMAGVLDSARLRTFLSERLNVSVDDIHALVMGGHGD 332
Query: 205 KTIIPL 210
T++PL
Sbjct: 333 -TMVPL 337
>UniRef50_Q18WQ6 Cluster: Malate dehydrogenase, NAD-dependent; n=2;
Desulfitobacterium hafniense|Rep: Malate dehydrogenase,
NAD-dependent - Desulfitobacterium hafniense (strain
DCB-2)
Length = 320
Score = 70.9 bits (166), Expect = 4e-11
Identities = 58/246 (23%), Positives = 123/246 (50%), Gaps = 12/246 (4%)
Query: 27 QVSVIGAA-SDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELSNLPGGPSVSAFIGD 85
++SVIG+ + + L +K + L +++ KG L++ S +
Sbjct: 3 KISVIGSGFTGTTTAFMLAMKGLGDIVLLDTQANENPTKGKALDIMEAGPLTRSSVRVTG 62
Query: 86 TNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNP 145
T+ Q S++VV+ + + RKPG +R ++ NA ++ + + + + + + I +NP
Sbjct: 63 TSDYQDTLDSDVVVITAGIARKPGMSRNELCDINAGIVTHVVRQVVQHSPNSTLIILSNP 122
Query: 146 INYLIPFASTVMYKYGCYNPSKMFGITHI-DTSRSRSFVAKALKINAQEIQVPVIGGHSD 204
++ + + V +K + +++ G + + D++R R FVA LK++A+++ V+G H D
Sbjct: 123 VDIM----TYVAFKESGFKRNRIIGQSGVLDSARFRYFVASELKVSAEDVTGFVLGVHGD 178
Query: 205 KTIIPLFSNLT----PRNYRIEPCQADMLTRLVRKAGTEVVMHKHGAESSTLAMAWSINE 260
++PL + P + + + + R+AG+E+V + G S+ A A ++ E
Sbjct: 179 -DMVPLVRYCSVHGIPIQQLLPEAEIEKIMERTRQAGSEIV-NLLGNGSAYYAPAAALTE 236
Query: 261 FIDIIL 266
I+ IL
Sbjct: 237 MIESIL 242
>UniRef50_A0RXX8 Cluster: Malate/L-lactate dehydrogenase; n=1;
Cenarchaeum symbiosum|Rep: Malate/L-lactate
dehydrogenase - Cenarchaeum symbiosum
Length = 302
Score = 69.7 bits (163), Expect = 1e-10
Identities = 57/240 (23%), Positives = 119/240 (49%), Gaps = 14/240 (5%)
Query: 28 VSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRI-KGTELELSNLPGGPSVSAFIGDT 86
+++IGA +G ++F S++ L D + + +G ++++++ + + +
Sbjct: 2 ITIIGAGK-VGGDAAMFCALRRLDSEILLLDIVEGLPQGEAMDINHMLAEQGIDTEVRGS 60
Query: 87 NLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPI 146
N + S++VV+V+ RKPG TR +L NA +++ + + + +++ + TNP+
Sbjct: 61 NDYSDMEGSDIVVVVAGAGRKPGMTRMDLLKINAGIVKGVVEKVKEHAKDSMIIPVTNPL 120
Query: 147 NYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHSDK 205
+ + + + YK + +++FG+ +D SR R F+ +A + I+ V+G H +
Sbjct: 121 DPI----TYIAYKTSGFEKNRVFGMGGMLDLSRFRQFIHEATGYSRDSIRALVMGEHGEN 176
Query: 206 TI-IPLFSNLT--PRNYRIEPCQADMLTRLVRKAGTEVVMHK----HGAESSTLAMAWSI 258
+ +P FS ++ P I +A L R +K +V+ K H +S AM SI
Sbjct: 177 MLPLPRFSTVSGIPLLSLISAEKAAELVRDTKKVAAKVIELKGATVHAPGNSISAMVESI 236
>UniRef50_A7DRG3 Cluster: Lactate/malate dehydrogenase; n=1;
Candidatus Nitrosopumilus maritimus SCM1|Rep:
Lactate/malate dehydrogenase - Candidatus Nitrosopumilus
maritimus SCM1
Length = 304
Score = 69.3 bits (162), Expect = 1e-10
Identities = 47/191 (24%), Positives = 101/191 (52%), Gaps = 8/191 (4%)
Query: 28 VSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRI-KGTELELSNLPGGPSVSAFIGDT 86
+++IG+ +G +LF ++ L D + + +G ++++++ + + +
Sbjct: 2 ITIIGSGK-VGGDAALFSALKRLDDQILLLDVAEGLPQGEAMDINHMLSEQGIDVEVKGS 60
Query: 87 NLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPI 146
N + + SN+VV+V+ RKPG TR +L NA +++ + + + ++ + TNP+
Sbjct: 61 NNFEDMKGSNIVVVVAGSGRKPGMTRMDLLKINASIVKSVVENVKKYADDSMIIPVTNPL 120
Query: 147 NYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHSDK 205
+ P A + YK ++ S++FG+ +D SR R F+ +A + I+ VIG H +
Sbjct: 121 D---PMA-YITYKVSGFDRSRVFGMGGMLDLSRFRQFIHEATGHSRDSIRALVIGEHGEN 176
Query: 206 TI-IPLFSNLT 215
+ +P FS+++
Sbjct: 177 MLPLPRFSSVS 187
>UniRef50_Q8YJE7 Cluster: Malate dehydrogenase; n=98; Bacteria|Rep:
Malate dehydrogenase - Brucella melitensis
Length = 320
Score = 69.3 bits (162), Expect = 1e-10
Identities = 48/186 (25%), Positives = 98/186 (52%), Gaps = 9/186 (4%)
Query: 27 QVSVIGAASDIGSYVSLF-LKRNSKVSKLHLYDDDDRIKGTELELSNLPGGPSVSAFIGD 85
++++IG+ G+ L LK V + + + KG ++ S+ G F G
Sbjct: 5 KIALIGSGMIGGTLAHLAGLKELGDVVLFDIAEGTPQGKGLDIAESSPVDGFDAK-FTG- 62
Query: 86 TNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNP 145
N AI +++V++ + +PRKPG +R+ +LG N +++++ I EAFV TNP
Sbjct: 63 ANDYAAIEGADVVIVTAGVPRKPGMSRDDLLGINLKVMEQVGAGIKKYAPEAFVICITNP 122
Query: 146 INYLIPFASTVMYKYGCYNPSKMFGITHI-DTSRSRSFVAKALKINAQEIQVPVIGGHSD 204
++ ++ + K+ K+ G+ + D++R R F+++ ++ +++ V+GGH D
Sbjct: 123 LDAMV----WALQKFSGLPAHKVVGMAGVLDSARFRYFLSEEFNVSVEDVTAFVLGGHGD 178
Query: 205 KTIIPL 210
+++PL
Sbjct: 179 -SMVPL 183
>UniRef50_Q5CYZ2 Cluster: Lactate dehydrogenase, adjacent gene
encodes predicted malate dehydrogenase; n=8;
Cryptosporidium|Rep: Lactate dehydrogenase, adjacent
gene encodes predicted malate dehydrogenase -
Cryptosporidium parvum Iowa II
Length = 337
Score = 68.9 bits (161), Expect = 2e-10
Identities = 50/192 (26%), Positives = 108/192 (56%), Gaps = 11/192 (5%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRI-KGTELELSN-LPGGPSVSAFIG 84
+++VIG+ IG ++ + +++ ++ + L+D + I +G L++++ + S S IG
Sbjct: 22 KIAVIGSGQ-IGGNIAYIVGKDN-LADVVLFDIAEGIPQGKALDITHSMVMFGSTSKVIG 79
Query: 85 DTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTN 144
TN I S++V++ + +P +P + R ++L NA ++ + + + AFV TN
Sbjct: 80 -TNDYADISGSDVVIITASIPGRPKDDRSELLFGNARILDSVAEGVKKYCPNAFVICITN 138
Query: 145 PINYLIPFASTVMYKYGCYNPSKMFGITHI-DTSRSRSFVAKALKINAQEIQVPVIGGHS 203
P++ ++ + K +K+ G+ + D+SR R+F+A+ +NA ++ VIGGH
Sbjct: 139 PLDVMV----SHFQKVSGLPHNKVCGMAGVLDSSRFRTFIAQHFGVNASDVSANVIGGHG 194
Query: 204 DKTIIPLFSNLT 215
D ++P+ S+++
Sbjct: 195 D-GMVPVTSSVS 205
>UniRef50_Q6LZI3 Cluster: Malate dehydrogenase; n=5;
Methanococcus|Rep: Malate dehydrogenase - Methanococcus
maripaludis
Length = 314
Score = 67.7 bits (158), Expect = 4e-10
Identities = 56/236 (23%), Positives = 119/236 (50%), Gaps = 20/236 (8%)
Query: 26 VQVSVIGAASDIGSYVSLFLKRNSKVSKLHLY---DDDDRIKGTELELSNLPGGPSVSAF 82
+ VS+IGA+ IGS +SL L + S + ++L +++KG +++L +
Sbjct: 1 MDVSIIGASGKIGSVLSLLLAKESHIKNINLIARSSSINKLKGLKMDLYDAMAAAGQDTD 60
Query: 83 IG---DTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFV 139
I D +L +S++ ++ + M R +R ++ NA +++ K IA
Sbjct: 61 IDICCDDDLS-CTANSDITIITAGMARTGEMSRIDLMKGNAKIVKNYVKNIANFGDTKIF 119
Query: 140 AISTNPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPV 198
IS NP++ L+ + + + + G Y +++FG+ TH+D+ R + VAK +++ +++ +
Sbjct: 120 MIS-NPVD-LMTYKALI--ESG-YEKNQVFGLGTHLDSMRFKVAVAKHFEVHLDDVRTRI 174
Query: 199 IGGHSDKTIIPLFSNLT------PRNYRIEPCQADMLTRLVRKAGTEVVMHKHGAE 248
+G H D +++P+ S R + E + + ++ G E++ K+G+E
Sbjct: 175 VGEHGD-SMVPVISATAVGGIPIKRLPKYEDFPYEKILERIKGYGQEIINLKNGSE 229
>UniRef50_A1U9V0 Cluster: Lactate/malate dehydrogenase; n=6;
Actinomycetales|Rep: Lactate/malate dehydrogenase -
Mycobacterium sp. (strain KMS)
Length = 329
Score = 66.9 bits (156), Expect = 7e-10
Identities = 55/192 (28%), Positives = 94/192 (48%), Gaps = 11/192 (5%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDD-RIKGTELELSNLPGGPSV-SAFIG 84
+VS+IGA S +G+ ++ L LYD + +++ L+L++ G V +G
Sbjct: 20 KVSIIGAGS-VGTAIAYACLIRGSAGTLALYDTNSAKVRAEVLDLNH--GSQFVPECRVG 76
Query: 85 DTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTN 144
++ S +VV+ + + PG +R + AN + Q L + + +A V TN
Sbjct: 77 GSDDIAVTAGSAIVVVTAGAKQHPGQSRLDLAAANVAMAQTLTPQLLEHSPDAVVIFVTN 136
Query: 145 PINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHS 203
P++ + AS+V+ P ++FG T +D+SR R VA+ I + VIG H
Sbjct: 137 PVDVVTYAASSVVDA----QPGQIFGTGTVLDSSRFRYLVAQRAAIAVGNVHALVIGEHG 192
Query: 204 DKTIIPLFSNLT 215
D IPL+S L+
Sbjct: 193 DSE-IPLWSTLS 203
>UniRef50_Q9PHY2 Cluster: Probable malate dehydrogenase; n=12;
Campylobacter|Rep: Probable malate dehydrogenase -
Campylobacter jejuni
Length = 300
Score = 66.9 bits (156), Expect = 7e-10
Identities = 50/223 (22%), Positives = 111/223 (49%), Gaps = 10/223 (4%)
Query: 26 VQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYD-DDDRIKGTELELSNLPGGPSVSAFIG 84
++++VIGA + +GS V+ L +++ L D ++D + ELEL+ +++ +
Sbjct: 1 MKITVIGAGN-VGSSVAYALILREIANEIVLVDINEDLLYAKELELTQSIAALNLNIDLL 59
Query: 85 DTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTN 144
T +S++V+ + RK G +RE++L N ++ K I ++ I TN
Sbjct: 60 CTKDYTHTKNSDIVLFSAGFARKDGQSREELLQLNTSIMLDCAKKIKDFTEDPLFIILTN 119
Query: 145 PINYLIPFASTVMYKYGCYNPSKMFGITHI-DTSRSRSFVAKALKINAQEIQVPVIGGHS 203
P+++L+ +Y+ G ++ K+ + + D +R + +AK L + + +IG H+
Sbjct: 120 PVDFLL----NTLYESGIFSSKKIIAMAGVLDNARFKYELAKKLNVKMSRVDTRLIGFHN 175
Query: 204 -DKTIIPLFSNLTPRNYR--IEPCQADMLTRLVRKAGTEVVMH 243
D ++ ++++ +N + + + L V+ G +V+ H
Sbjct: 176 DDMVLVKSYASVKNKNISEFLNEEEFEDLENEVKTGGAKVIKH 218
>UniRef50_Q8ZVB2 Cluster: Malate dehydrogenase; n=14;
Thermoprotei|Rep: Malate dehydrogenase - Pyrobaculum
aerophilum
Length = 309
Score = 66.1 bits (154), Expect = 1e-09
Identities = 44/185 (23%), Positives = 99/185 (53%), Gaps = 8/185 (4%)
Query: 28 VSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRI-KGTELELSNLPGGPSVSAFIGDT 86
+++IG+ +G+ ++ + +K+ L D + +G L+++++ + +
Sbjct: 2 ITIIGSGR-VGTAAAVIMGLMKLDNKILLIDIVKGLPQGEALDMNHMSSILGLDVEYVGS 60
Query: 87 NLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPI 146
N + I S+L+++ + +PRKPG TREQ+L ANA ++ + + I ++ V ++TNP+
Sbjct: 61 NEYKDIEGSDLIIVTAGLPRKPGMTREQLLEANAKIVAEIGREIKKYAPDSIVILTTNPL 120
Query: 147 NYLIPFASTVMYKYGCYNPSKMFGITHI-DTSRSRSFVAKALKINAQEIQVPVIGGHSDK 205
+ + + VM+K + ++ G + + D R + AK L I+ I +P++ G +
Sbjct: 121 DAM----TYVMWKATGFPRERVIGFSGVLDAGRLAFYAAKKLGISPASI-LPIVLGQHGE 175
Query: 206 TIIPL 210
++ P+
Sbjct: 176 SMFPV 180
>UniRef50_P59390 Cluster: L-lactate dehydrogenase 2; n=8;
Lactobacillus|Rep: L-lactate dehydrogenase 2 -
Lactobacillus plantarum
Length = 309
Score = 66.1 bits (154), Expect = 1e-09
Identities = 46/193 (23%), Positives = 97/193 (50%), Gaps = 15/193 (7%)
Query: 21 LQKRNVQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELSNLPGGPSVS 80
+ K+ +V ++G S +GS + L +N + +L + D + T E ++ V+
Sbjct: 1 MDKKQRKVVIVGDGS-VGSSFAFSLVQNCALDELVIVD----LVKTHAE-GDVKDLEDVA 54
Query: 81 AFIGDTNLEQAIHS----SNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQE 136
AF TN+ ++ +++VV+ + +PRKPG +R ++ N +++ + K + A
Sbjct: 55 AFTNATNIHTGEYADARDADIVVITAGVPRKPGESRLDLINRNTKILESIVKPVVASGFN 114
Query: 137 AFVAISTNPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQ 195
IS+NP++ L +++ + + ++ G T +DT+R R +A+ L + +
Sbjct: 115 GCFVISSNPVDIL----TSMTQRLSGFPRHRVIGTGTSLDTARLRVALAQKLNVATTAVD 170
Query: 196 VPVIGGHSDKTII 208
V+G H D +I+
Sbjct: 171 AAVLGEHGDSSIV 183
>UniRef50_A4L2P0 Cluster: L-lactate dehydrogenase; n=4;
Lactobacillus|Rep: L-lactate dehydrogenase -
Lactobacillus reuteri
Length = 312
Score = 64.9 bits (151), Expect = 3e-09
Identities = 55/229 (24%), Positives = 109/229 (47%), Gaps = 17/229 (7%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYD-DDDRIKGTELELSNL-PGGPSVSAFIG 84
+V +IG + S+ FL+ ++V +L L D + G +L+++ P V + G
Sbjct: 8 KVVLIGDGAVGSSFAFSFLQSTNEVDELVLVDRTKSKAVGDAADLADITPLTNPVKIYAG 67
Query: 85 DTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTN 144
E A +++VV+ + +PRKPG TR ++ N +++ + K I IS+N
Sbjct: 68 --TYEDAA-DADVVVITAGIPRKPGETRLDLVNKNTTILKSIIKPIVKSGFTGVFVISSN 124
Query: 145 PINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHS 203
P++ L +T+ + + ++ G T +D+ R R ++K L ++ I ++G H
Sbjct: 125 PVDIL----TTIAQRISGFPKERVIGTGTSLDSMRLRVLLSKKLHLSVNVIDALMLGEHG 180
Query: 204 DKTIIPLFSNLTPRNYRIEPCQA------DMLTRLVRKAGTEVVMHKHG 246
D T F+ +T + A + + V +AG++++ +K G
Sbjct: 181 D-TSFAAFNEITIGGKALNIITALSNTDKSEIEKAVHEAGSQIIANKGG 228
>UniRef50_Q5LXE1 Cluster: Malate dehydrogenase; n=115; cellular
organisms|Rep: Malate dehydrogenase - Silicibacter
pomeroyi
Length = 320
Score = 64.1 bits (149), Expect = 5e-09
Identities = 42/185 (22%), Positives = 97/185 (52%), Gaps = 9/185 (4%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYD-DDDRIKGTELELSNLPGGPSVSAFIGD 85
++++IGA G+ L + ++ + L+D + +G L+++ A +
Sbjct: 5 KIALIGAGQIGGTLAHLVALK--ELGDVVLFDIAEGTPEGKALDIAESGPSEGFDAKLKG 62
Query: 86 TNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNP 145
T I +++ ++ + +PRKPG +R+ +LG N +++ + + I +AFV TNP
Sbjct: 63 TQSYADIAGADVCIVTAGVPRKPGMSRDDLLGINLKVMKSVGEGIRDNAPDAFVICITNP 122
Query: 146 INYLIPFASTVMYKYGCYNPSKMFGITHI-DTSRSRSFVAKALKINAQEIQVPVIGGHSD 204
++ ++ + ++ +K+ G+ + D++R R F+A+ ++ +++ V+GGH D
Sbjct: 123 LDAMV----WALQQFSGLPANKVCGMAGVLDSARFRHFLAEEFNVSMKDVTAFVLGGHGD 178
Query: 205 KTIIP 209
T++P
Sbjct: 179 -TMVP 182
>UniRef50_Q892U0 Cluster: L-lactate dehydrogenase; n=12;
Bacteria|Rep: L-lactate dehydrogenase - Clostridium
tetani
Length = 316
Score = 63.3 bits (147), Expect = 9e-09
Identities = 43/190 (22%), Positives = 94/190 (49%), Gaps = 11/190 (5%)
Query: 21 LQKRNVQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYD-DDDRIKGTELELSN-LPGGPS 78
+ K+ +++S+IG+ +GS + L S++ + D + ++ KG ++LS+ +
Sbjct: 1 MNKKGIKISIIGSGF-VGSTTAYALMMEGLASEIVIVDINKEKAKGEAMDLSHGVSFVKP 59
Query: 79 VSAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAF 138
V GD + S++V++ + KPG TR ++ N + + + + + ++
Sbjct: 60 VDIIAGDY---EDTKDSDIVIITAGAGPKPGETRLDLINKNYEIFKGIVPEVVKYSPKSI 116
Query: 139 VAISTNPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVP 197
+ + +NP++ L + V YK + ++ G T +DTSR R + + KI+ + +
Sbjct: 117 LLVVSNPVDIL----TYVTYKLSGFPQERVIGSGTVLDTSRFRYLLGEHFKIDVRNVHTY 172
Query: 198 VIGGHSDKTI 207
++G H D I
Sbjct: 173 ILGEHGDSEI 182
>UniRef50_Q07841 Cluster: Malate dehydrogenase; n=7;
Halobacteriaceae|Rep: Malate dehydrogenase - Haloarcula
marismortui (Halobacterium marismortui)
Length = 304
Score = 62.5 bits (145), Expect = 2e-08
Identities = 44/193 (22%), Positives = 96/193 (49%), Gaps = 13/193 (6%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELSNLPGGPSVSAFIGDT 86
+VSV+GAA +G+ + ++ D D+ T + ++ G A+ +T
Sbjct: 3 KVSVVGAAGTVGAAAGYNIALRDIADEVVFVDIPDKEDDTVGQAADTNHG---IAYDSNT 59
Query: 87 NLEQAIHS----SNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAIS 142
+ Q + S++VV+ + +PR+PG TR + G NAP+++ + ++ N + +
Sbjct: 60 RVRQGGYEDTAGSDVVVITAGIPRQPGQTRIDLAGDNAPIMEDIQSSLDEHNDDYISLTT 119
Query: 143 TNPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGG 201
+NP++ L + +Y+ G + ++ G +D++R R +++ Q ++ ++G
Sbjct: 120 SNPVDLL----NRHLYEAGDRSREQVIGFGGRLDSARFRYVLSEEFDAPVQNVEGTILGE 175
Query: 202 HSDKTIIPLFSNL 214
H D +P+FS +
Sbjct: 176 HGDAQ-VPVFSKV 187
>UniRef50_Q1IRL5 Cluster: L-lactate dehydrogenase; n=6;
Bacteria|Rep: L-lactate dehydrogenase - Acidobacteria
bacterium (strain Ellin345)
Length = 321
Score = 62.1 bits (144), Expect = 2e-08
Identities = 42/189 (22%), Positives = 96/189 (50%), Gaps = 10/189 (5%)
Query: 26 VQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELSN-LPGGPSVSAFIG 84
++++V+G + S+ L+R + + + + +G ++L++ +P G + + G
Sbjct: 11 LRIAVVGLGNVGASFAFALLQRRLAAEIVLIDANHKKAEGEAMDLNHAVPFGAATRIWAG 70
Query: 85 DTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTN 144
+ + + V+ + ++PG TR Q+L N + Q++ + N + + I+TN
Sbjct: 71 EY---ADCRGAAVTVITAGAAQRPGETRLQLLDRNLAIFQQIVPEVVKHNPDGLLLIATN 127
Query: 145 PINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHS 203
P++ +I +AS YK ++ G T +DT+R R + + ++A+ + ++G H
Sbjct: 128 PVD-IISYAS---YKISGLPAHRVLGSGTILDTARFRYLLGQHFSVDARSVHGLILGEHG 183
Query: 204 DKTIIPLFS 212
D T +P++S
Sbjct: 184 D-TEVPIWS 191
>UniRef50_Q3ZZJ7 Cluster: Malate dehydrogenase; n=5; cellular
organisms|Rep: Malate dehydrogenase - Dehalococcoides
sp. (strain CBDB1)
Length = 307
Score = 62.1 bits (144), Expect = 2e-08
Identities = 67/283 (23%), Positives = 124/283 (43%), Gaps = 18/283 (6%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELSNLPGGPSVSAFIGDT 86
++SVIGA + +G+ ++ L + L + +G L++S I +
Sbjct: 3 KISVIGAGN-VGATLAQRLIEKDFADVVMLDVVEGIPQGKALDISQSASVLGFRHTITGS 61
Query: 87 NLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPI 146
N S +VV+ + + RKPG TRE++L N ++ + + EA + + +NP+
Sbjct: 62 NDYAQTAGSEIVVITAGIARKPGMTREELLAINQKIMTDVVSNCLKYSPEATLVVVSNPV 121
Query: 147 NYLIPFASTVMYKYGCYNPSKMFGITHI-DTSRSRSFVAKALKINAQEIQVPVIGGHSDK 205
+ + A +K ++ G++ + D R +FVA+ L +N + V+G H
Sbjct: 122 DTMTYLA----WKLSGLPRKRVVGLSGVLDGGRLATFVARELGVNPSAVSPCVMGEHGGS 177
Query: 206 TIIP---LFSNLTPRNYRIEPCQADMLTRLVRKAGTEVVMH-KHGAESSTLAMAWSINEF 261
++ N P + + P +AD L + G E+V K G S+ A + S+
Sbjct: 178 MVVMSRFTLVNGKPLSELVSPEKADELAKRAVNGGAEIVAFLKTG--SAFYAPSASVAAM 235
Query: 262 IDIILDAILGYRVVVNCYTA-NSNFGTK--FFAGPTSVGPHGI 301
++ I LG V+NC + +G + P +G GI
Sbjct: 236 VEAI---FLGSGKVMNCAAVLDGEYGLRNIVLGVPVKLGKGGI 275
>UniRef50_A5KJY5 Cluster: Putative uncharacterized protein; n=2;
Ruminococcus|Rep: Putative uncharacterized protein -
Ruminococcus torques ATCC 27756
Length = 316
Score = 61.7 bits (143), Expect = 3e-08
Identities = 40/186 (21%), Positives = 97/186 (52%), Gaps = 10/186 (5%)
Query: 25 NVQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDD-RIKGTELELSN-LPGGPSVSAF 82
N+Q + + +GS ++ L + S++ L D + + +G +++S+ LP ++ +
Sbjct: 3 NIQKAAVIGCGFVGSTIAYTLMQKGLFSEMVLLDANKAKAEGEAMDISHGLPFTHAMDIY 62
Query: 83 IGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAIS 142
G+ + I +++V++ + +KPG TR ++ NA +++ + K I N E + I
Sbjct: 63 AGEY---EDIADASVVIITAGANQKPGETRLDLVQKNAAIMRSIIKEIKRVNCEGILLIV 119
Query: 143 TNPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGG 201
+NP++ L + V + + ++ G T +DT+R + +++ L ++++ + ++G
Sbjct: 120 SNPVDIL----TEVALRESGFPKERVIGSGTVLDTARLKYIISEKLDVDSRNVHAFIVGE 175
Query: 202 HSDKTI 207
H D +
Sbjct: 176 HGDSEL 181
>UniRef50_P11386 Cluster: Malate dehydrogenase; n=6;
Sulfolobaceae|Rep: Malate dehydrogenase - Sulfolobus
acidocaldarius
Length = 306
Score = 61.7 bits (143), Expect = 3e-08
Identities = 51/191 (26%), Positives = 91/191 (47%), Gaps = 9/191 (4%)
Query: 26 VQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRI-KGTELELSNLPGGPSVSAFIG 84
V+V+ IG +G ++ N ++ LYD + + E E+ + V +
Sbjct: 2 VKVAFIGVGR-VGQTIAYNTIVNGYADEVMLYDVVPELPEKFEHEIRHALAALRVKTELL 60
Query: 85 DTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTN 144
TN I +++VV+ + PRKPG +R + NA ++ L K + +N+ A + N
Sbjct: 61 STNNIDDISGADIVVITAGKPRKPGMSRRDLFIDNAKIMIDLAKKLPKKNKGAMYIMVAN 120
Query: 145 PINYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEIQVPVIGGHSD 204
P++ + ++V KY N ++T R RS++AK L I A E+ V G H +
Sbjct: 121 PVDMM----ASVFMKYSGENTISTG--NQVETMRMRSYIAKKLNIPAYEVGGYVGGEHGE 174
Query: 205 KTIIPLFSNLT 215
++ L+S +T
Sbjct: 175 AAMV-LWSTVT 184
>UniRef50_Q8XP62 Cluster: L-lactate dehydrogenase; n=11;
Clostridium|Rep: L-lactate dehydrogenase - Clostridium
perfringens
Length = 317
Score = 61.7 bits (143), Expect = 3e-08
Identities = 66/324 (20%), Positives = 132/324 (40%), Gaps = 18/324 (5%)
Query: 19 LILQKRNVQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYD-DDDRIKGTELELSNLPGGP 77
+I +K N ++S+IGA +GS + L ++ S++ + D + D+ ++L+ G
Sbjct: 1 MIREKTN-KISIIGAGF-VGSTTAFALMQDGLASEIVIVDINKDKAHAEAMDLAQ--GAA 56
Query: 78 SVSAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEA 137
V + + S++V++ + + KPG TR ++ N + Q + + + +
Sbjct: 57 FVKSVDIKSGDYADTKDSDIVIITAGVGPKPGETRLDIINKNLKIFQSIVPEVVKYSPNS 116
Query: 138 FVAISTNPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQV 196
+ + +NP++ L + + YK + ++ G T +DTSR + +++ I+A+ +
Sbjct: 117 ILLVVSNPVDIL----TYITYKLSGFPKERVIGSGTVLDTSRLKYMLSEHFDIDARNVHT 172
Query: 197 PVIGGHSDKTIIP-LFSNLTPRNYR------IEPCQADMLTRLVRKAGTEVVMHKHGAES 249
+IG H D I +N+ N C L K +
Sbjct: 173 YIIGEHGDSEITAWSLTNIAGANVEEYCKTVCANCDGSFKKELPEKVKNAAYEIINSKGY 232
Query: 250 STLAMAWSINEFIDIILDAILGYRVVVNCYTANSNFGTKFFAGPTSVGPHGIIQACCHFP 309
+ A+A ++ ++ IL V + + + A PT V G Q P
Sbjct: 233 TNYAVALAVTRIVEAILRDENAILTVSSLFEGQYGIDNVYLAMPTIVDRSGARQ-ILDVP 291
Query: 310 MSEFESYLLNRCIPILSREVLEGE 333
+S E L + IL + E
Sbjct: 292 ISNEEKENLIKSAEILKGHIANSE 315
>UniRef50_O67581 Cluster: Malate dehydrogenase 2; n=1; Aquifex
aeolicus|Rep: Malate dehydrogenase 2 - Aquifex aeolicus
Length = 334
Score = 60.5 bits (140), Expect = 6e-08
Identities = 38/157 (24%), Positives = 84/157 (53%), Gaps = 10/157 (6%)
Query: 90 QAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPINYL 149
+ + S++VV+ + +PR+ G +RE +L N ++++ AI +++ + + +NP++ L
Sbjct: 84 EELKGSDIVVITAGIPRREGMSREDLLYENLKILKKFTDAIKEYAKDSIIIVVSNPVDTL 143
Query: 150 IPFASTVMYKYGCYNPSKMFGITHI-DTSRSRSFVAKALKINAQEIQVPVIGGHSDKTII 208
+ K + P ++ G+ + D++R ++FV + + I+ +I+ V+G H D ++
Sbjct: 144 ----TYATIKLTGFEPRRVIGMAGVLDSARFKNFVKEKIGISNADIRTLVLGTHGD-LMV 198
Query: 209 PLFSNLTPRNYRIE----PCQADMLTRLVRKAGTEVV 241
P+ S+ + IE + D L RK G ++V
Sbjct: 199 PVTSHSFIGDKPIEEVFSASEIDELIEKTRKGGAQIV 235
>UniRef50_Q9P7P7 Cluster: Probable L-lactate dehydrogenase; n=2;
Ascomycota|Rep: Probable L-lactate dehydrogenase -
Schizosaccharomyces pombe (Fission yeast)
Length = 330
Score = 60.5 bits (140), Expect = 6e-08
Identities = 39/187 (20%), Positives = 93/187 (49%), Gaps = 11/187 (5%)
Query: 24 RNVQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYD-DDDRIKGTELELSNL-PGGPSVSA 81
+++++ ++GA + +GS + L + +++ + D + + +G ++L++ P
Sbjct: 19 KSIKIVIVGAGN-VGSTTAFTLLLSGLAAEIVIIDLNKKKAEGEAMDLNHAAPLSHETRV 77
Query: 82 FIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAI 141
++GD + + VV+ + +KPG TR +L AN + + + + + ++A + +
Sbjct: 78 YLGDY---KDCKDATAVVITAGKNQKPGETRMDLLKANISIFKEILREVTKYTKDAILLV 134
Query: 142 STNPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIG 200
+TNP++ L + K + ++ G T IDT+R + + K ++ Q + +IG
Sbjct: 135 ATNPVDVL----TYATLKLTGFPAERVIGSGTIIDTARFQYLIGKLYGLDPQSVNADIIG 190
Query: 201 GHSDKTI 207
H D +
Sbjct: 191 EHGDSEL 197
>UniRef50_Q4Q7X6 Cluster: Cytosolic malate dehydrogenase, putative;
n=7; Eukaryota|Rep: Cytosolic malate dehydrogenase,
putative - Leishmania major
Length = 324
Score = 59.7 bits (138), Expect = 1e-07
Identities = 68/277 (24%), Positives = 118/277 (42%), Gaps = 22/277 (7%)
Query: 26 VQVSVIGAASDIGSYVSLFLKRNSKVS-----KLHLYDDDDRIK---GTELELSNLPGGP 77
V+V+V GAA IG + + R + + +L L D + +K G E EL + P
Sbjct: 4 VKVAVTGAAGQIGYALVPLIARGALLGPTTPVELRLLDIEPALKALAGVEAELEDC-AFP 62
Query: 78 SVSAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAA-QNQE 136
+ + + A + +M PRK G R+ +L NA + + +AIAA +
Sbjct: 63 LLDKVVVTADPRVAFDGVAIAIMCGAFPRKAGMERKDLLEMNARIFKEQGEAIAAVAASD 122
Query: 137 AFVAISTNP--INYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEI 194
V + NP N LI S G NP + +T +D +R+ S +A+ + ++
Sbjct: 123 CRVVVVGNPANTNALILLKSA----QGKLNPRHVTAMTRLDHNRALSLLARKAGVPVSQV 178
Query: 195 QVPVIGGHSDKTIIP----LFSNLTPRNYRI-EPCQADMLTRLVRKAGTEVVMHKHGAES 249
+ +I G+ T +P TP I + D ++VR G E++ + G S
Sbjct: 179 RNVIIWGNHSSTQVPDTDSAVIGTTPAREAIKDDALDDDFVQVVRGRGAEIIQLR-GLSS 237
Query: 250 STLAMAWSINEFIDIILDAILGYRVVVNCYTANSNFG 286
+ A +++ D I G V + Y+ + +G
Sbjct: 238 AMSAAKAAVDHVHDWIHGTPEGVYVSMGVYSDENPYG 274
>UniRef50_Q6A9C3 Cluster: L-lactate dehydrogenase; n=2;
Propionibacterium acnes|Rep: L-lactate dehydrogenase -
Propionibacterium acnes
Length = 319
Score = 59.7 bits (138), Expect = 1e-07
Identities = 51/201 (25%), Positives = 97/201 (48%), Gaps = 16/201 (7%)
Query: 17 NTLILQKRNVQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYD-DDDRIKGTELELSNLPG 75
+T +R ++SV+GA S +GS ++ + LYD D++ E E+++L
Sbjct: 2 STFDATRRASKISVVGAGS-VGSSLAYACLIRGSAGLVSLYDIAKDKV---EAEVADLAH 57
Query: 76 GPSVS--AFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQ 133
G + + +G ++ S++V + + +KPG TR + G NA +++ L + Q
Sbjct: 58 GTQFTPASVMGGADVHDTA-DSDVVFITAGARQKPGQTRLDLAGVNANILRSLMPQLVEQ 116
Query: 134 NQEAFVAISTNPINYLIPFASTVMYKYGCYNP-SKMFGI-THIDTSRSRSFVAKALKINA 191
+ A + TNP + L TV+ + P +++F T +DTSR R + + +
Sbjct: 117 SPNALFVLVTNPCDVL-----TVVAQEATGLPANRVFSTGTMLDTSRLRWLIRQWANVEQ 171
Query: 192 QEIQVPVIGGHSDKTIIPLFS 212
+ + ++G H D PL+S
Sbjct: 172 RHVHATIVGEHGDSE-FPLWS 191
>UniRef50_A1HSK3 Cluster: Lactate/malate dehydrogenase; n=1;
Thermosinus carboxydivorans Nor1|Rep: Lactate/malate
dehydrogenase - Thermosinus carboxydivorans Nor1
Length = 303
Score = 59.3 bits (137), Expect = 1e-07
Identities = 57/213 (26%), Positives = 103/213 (48%), Gaps = 19/213 (8%)
Query: 95 SNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPINYLIPFAS 154
+++VV+ + +PRK R +L NA LI L + + + + TNP++ + A
Sbjct: 68 ADIVVITAGIPRKADEPRVLLLSRNAALIADLVRQAVHYSPNCIIFMVTNPLDVMTQLA- 126
Query: 155 TVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHSDKTIIPLFSN 213
Y+ +++ G+ T +DT+R RS++A A +A++I V+G H + T++ L S
Sbjct: 127 ---YQVSGLPANRVIGMGTVLDTARYRSYLAVAFDADARDIDAYVVGEHGE-TMVCLTSQ 182
Query: 214 LTPRNYRIEPC----QADM--LTRLVRKAGTEVVMHKHGAESSTLAMAWSINEFIDIILD 267
+T R + QA + + V +A ++V+ K G + A ++ E I+ D
Sbjct: 183 ITVRGVPLTALPGYDQAKLAPIIENVVQASSQVIALKGGTVFAPATAACAVLE--AIVRD 240
Query: 268 AILGYRVVVNCYTANSNFGTKFFAGPTSVGPHG 300
+ R V+ T N +G + PT VG G
Sbjct: 241 S----RAVLPVCTYNPQYGVA-LSLPTIVGRGG 268
>UniRef50_Q7UY63 Cluster: L-lactate/malate dehydrogenase; n=2;
Planctomycetaceae|Rep: L-lactate/malate dehydrogenase -
Rhodopirellula baltica
Length = 304
Score = 58.8 bits (136), Expect = 2e-07
Identities = 71/312 (22%), Positives = 138/312 (44%), Gaps = 15/312 (4%)
Query: 26 VQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDD-DRIKGTELELSNLPGGPSVSAFIG 84
++++++G +GS ++ L N S+L L + ++ +G L+L++ + I
Sbjct: 1 MKITLVGTGR-VGSAIAFALTINPLASELLLLNRSREKAEGDALDLTHAAALVDSNIKIS 59
Query: 85 DTNLEQAIHSSNLVVMVSRMP-RKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAIST 143
+ + S++++ + +P R P TR +M N P+++ +A + A V + +
Sbjct: 60 SGEIADS-KDSDVIIFTASVPFRYPNQTRLEMGIDNMPILRDWMPGLAKASPNAIVVMVS 118
Query: 144 NPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGH 202
NP++ L A + G ++P ++ G T +D+ R R+ ++ LKI+AQ+I+ ++G H
Sbjct: 119 NPVDAL---AYETIRLTG-FDPKRVIGTGTLVDSIRYRALLSTELKIHAQDIRAYILGEH 174
Query: 203 SDKTIIPLFSNLTPRNYRIEPCQADMLTRLVRKAGTEVVMHKHGAESSTLAMAW-SINEF 261
D T S R P KA V G S +AMA +I +
Sbjct: 175 GD-TQFAASSIAMTGGERFYPSDTSRRMFEETKAMGYEVFRLKGHTSYGIAMATITILDS 233
Query: 262 IDIILDAILGYRVVVNCYTANSNFGTKFFAGPTSVGPHGIIQACCHFPMSEFESYLLNRC 321
I L + V+V+ Y + P +G G+ + H +SE E
Sbjct: 234 IAYDLRHTMPVSVLVDGYLGVEDVCLSL---PAVIGREGVTR-ILHPTLSEDEEAAFRNS 289
Query: 322 IPILSREVLEGE 333
++ + ++E E
Sbjct: 290 AEVVKQTLVEME 301
>UniRef50_P0A3M9 Cluster: L-lactate dehydrogenase; n=140;
Bacteria|Rep: L-lactate dehydrogenase - Streptococcus
pneumoniae
Length = 328
Score = 58.8 bits (136), Expect = 2e-07
Identities = 61/260 (23%), Positives = 117/260 (45%), Gaps = 20/260 (7%)
Query: 95 SNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPINYLIPFAS 154
++LVV+ + P+KPG TR ++G N + + + + + ++ NP++ L S
Sbjct: 77 ADLVVITAGAPQKPGETRLDLVGKNLAINKSIVTQVVESGFKGIFLVAANPVDVLT--YS 134
Query: 155 TVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHSDKTI-IPLFS 212
T +K+ + ++ G T +D++R R +A+ L ++A+ + ++G H D + +
Sbjct: 135 T--WKFSGFPKERVIGSGTSLDSARFRQALAEKLDVDARSVHAYIMGEHGDSEFAVWSHA 192
Query: 213 NLTPRN--------YRIEPCQADMLTRLVRKAGTEVVMHKHGAESSTLAMAWS-INEFID 263
N+ N ++ + L VR A ++ +K GA +A+A + I + I
Sbjct: 193 NIAGVNLEEFLKDTQNVQEAELIELFEGVRDAAYTII-NKKGATYYGIAVALARITKAIL 251
Query: 264 IILDAILGYRVVVNCYTANSNFGTKFFAGPTSVGPHGIIQACCHFPMSEFESYLLNRCIP 323
+A+L V N F P VG HGI++ + P+++ E+ +
Sbjct: 252 DDENAVLPLSVFQEGQYGVENV---FIGQPAVVGAHGIVRP-VNIPLNDAETQKMQASAK 307
Query: 324 ILSREVLEGEKYVEFMENVK 343
L + E K EF E K
Sbjct: 308 ELQAIIDEAWKNPEFQEASK 327
>UniRef50_O51114 Cluster: L-lactate dehydrogenase; n=4; Borrelia
burgdorferi group|Rep: L-lactate dehydrogenase -
Borrelia burgdorferi (Lyme disease spirochete)
Length = 316
Score = 58.8 bits (136), Expect = 2e-07
Identities = 44/184 (23%), Positives = 95/184 (51%), Gaps = 11/184 (5%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYD-DDDRIKGTELELSN--LPGGPSVSAFI 83
+V +IGA S+ NS V +L + D ++++ KG ++L++ + +++
Sbjct: 6 KVVLIGAGGVGSSFAYALTIDNSLVHELVIIDVNENKAKGEVMDLNHGQMFLKKNINVLF 65
Query: 84 GDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAIST 143
G T + A ++++VV+ + + +KPG TR ++ N+ + + + + + + +++
Sbjct: 66 G-TYKDCA--NADIVVITAGLNQKPGETRLDLVDKNSKIFKDIITNVVSSGFDGIFVVAS 122
Query: 144 NPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGH 202
NP++ + + V KY + K+ G T +DTSR R F++ +N Q I ++G H
Sbjct: 123 NPVDIM----TYVTMKYSKFPIHKVIGTGTILDTSRLRYFLSDHFNVNTQNIHSYIMGEH 178
Query: 203 SDKT 206
D +
Sbjct: 179 GDSS 182
>UniRef50_Q6KIP9 Cluster: L-lactate dehydrogenase; n=1; Mycoplasma
mobile|Rep: L-lactate dehydrogenase - Mycoplasma mobile
Length = 318
Score = 58.4 bits (135), Expect = 3e-07
Identities = 40/190 (21%), Positives = 93/190 (48%), Gaps = 10/190 (5%)
Query: 21 LQKRNVQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIK-GTELELSNLPGGPSV 79
+ K+ +V+++GA +G V + + D +D++ G L+ + +
Sbjct: 1 MDKKIKRVAMVGAGL-VGVSVLYSCMNRGLAEQYGIIDINDKLSVGHSLDFEDASAANNH 59
Query: 80 SAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFV 139
+ +G + ++VV+ + P+KPG TR +M+ NA ++ + K I +
Sbjct: 60 NFSVGKIEYSD-LKDYDVVVITAGRPQKPGETRLEMVADNAKIMSNIAKNIKKSGFKGVS 118
Query: 140 AISTNPINYLIPFASTVMYKYGC-YNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVP 197
+ NP++ + T +Y++ ++ +++ T +D++R R ++K LK++ + +Q
Sbjct: 119 IVVANPVDVM-----TFIYQHETGFDKNRVISSGTSLDSARLRFEISKKLKVHPKSVQAF 173
Query: 198 VIGGHSDKTI 207
V+G H D ++
Sbjct: 174 VLGEHGDSSV 183
>UniRef50_A0C8S6 Cluster: Malate dehydrogenase; n=3; Paramecium
tetraurelia|Rep: Malate dehydrogenase - Paramecium
tetraurelia
Length = 356
Score = 58.0 bits (134), Expect = 3e-07
Identities = 57/234 (24%), Positives = 108/234 (46%), Gaps = 17/234 (7%)
Query: 26 VQVSVIGAASDIG-SYVSLF-----LKRNSKV--SKLHLYDDDDRIKGTELELSNLPGGP 77
V+V+V GAA +IG + V + L N ++ + L L D+++GT +EL + P
Sbjct: 27 VRVTVTGAAGNIGYALVHMIGQGRLLGPNQQIILTLLELPMAKDQLEGTMMELRDC-AFP 85
Query: 78 SVSAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAA-QNQE 136
+ G T +Q + ++V PR PG R+ +L ANA + + +A+ ++
Sbjct: 86 ILKEIRGTTQYDQGFMGCEIAILVGAKPRGPGMERKDLLAANARIFKEQGEALEKYASKN 145
Query: 137 AFVAISTNPINYLIPFASTVMYKYGCYNPSKMF-GITHIDTSRSRSFVAKALKINAQEIQ 195
V + NP N + + ++ P F +T +D +R++S +A+ + N ++++
Sbjct: 146 VKVLVVGNPAN----TNALITAQFAPSIPKSNFTALTRLDQNRAQSIIAQRVSANVEDVR 201
Query: 196 VPVIGGHSDKTIIPLFSNLTPRNYRIEPCQADMLT--RLVRKAGTEVVMHKHGA 247
+I G+ T S T + I ++ ++KA E V + GA
Sbjct: 202 NIIIWGNHSTTQFADVSQATVQQNGISQTVRGLVADDAWLQKAFVEQVAKRGGA 255
>UniRef50_Q81K80 Cluster: L-lactate dehydrogenase 2; n=12;
Firmicutes|Rep: L-lactate dehydrogenase 2 - Bacillus
anthracis
Length = 314
Score = 57.6 bits (133), Expect = 4e-07
Identities = 44/208 (21%), Positives = 100/208 (48%), Gaps = 10/208 (4%)
Query: 23 KRNVQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYD-DDDRIKGTELELSN-LPGGPSVS 80
K+ + V+ +G + + + L D ++ + +G ++LS+ +P PS +
Sbjct: 2 KKGINRVVLVGTGAVGCSYAYSMINQGVAEEFVLVDVNEAKAEGEAMDLSHAVPFSPSPT 61
Query: 81 AFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVA 140
+ + ++LVV+ + +P+KPG TR ++ N + +++ + I +
Sbjct: 62 KVWSGSYAD--CKDADLVVITAGLPQKPGETRLDLVEKNTKIFKQIVRGIMDSGFDGIFL 119
Query: 141 ISTNPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVI 199
I+TNP++ L + V +K ++ G T +D++R R + L ++ + + ++
Sbjct: 120 IATNPVDIL----TYVTWKESGLPKERVIGSGTTLDSARFRYMLGDYLDVDPRNVHAYIV 175
Query: 200 GGHSDKTIIPLFSNLTPRNYRIEPCQAD 227
G H D T +P++S+ T ++E A+
Sbjct: 176 GEHGD-TELPVWSHATIGVQKLETILAN 202
>UniRef50_Q8IE66 Cluster: Oxidoreductase, putative; n=6;
Plasmodium|Rep: Oxidoreductase, putative - Plasmodium
falciparum (isolate 3D7)
Length = 334
Score = 56.8 bits (131), Expect = 8e-07
Identities = 75/298 (25%), Positives = 139/298 (46%), Gaps = 31/298 (10%)
Query: 24 RNVQVSVIGAASDIGSYVS-LFLKRNSKVSKLHLYDDDDRIKGTELE-LSNLPGGPSVSA 81
++ ++SV+GA DIG ++ + ++N LH + D KG L+ L P S
Sbjct: 5 KHPKISVLGAG-DIGCALAHMICEKNLGDVVLHDFRKD-LPKGRALDILHTRPLNRSRIN 62
Query: 82 FIGDTNLEQAIHSSNLVVMVSRMPRK-----PGNTREQMLGANAPLIQRLCKAIAAQNQE 136
+G + S +VV + R+ + +Q+ +N L++ + K++ +
Sbjct: 63 ILGTNEITDIKDSLVVVVTIEVSEREFAEFDEEDLEKQVYTSNVKLLKEVAKSLKKHCPQ 122
Query: 137 AFVAISTNPINYLIPFASTVMYKYGCYNPSKMFGITHI-DTSRSRSFVAKALKINAQEIQ 195
AFV ++T+P++ + + V+ ++ P K+ G+ + ++R R +A+ L++N ++Q
Sbjct: 123 AFVVVTTSPVDCM----AKVLQEHANIPPHKICGMAGVLHSARLRHNLAEKLRVNPGDVQ 178
Query: 196 VPVIGGHSDKTI----------IPLFSNLTPRNYRIEPCQADMLTRLVRKAGTEVVMHKH 245
VIG H DK + IPL S+ T + I + + + R G E ++
Sbjct: 179 GFVIGAHGDKMVPLPRYCCVNGIPL-SDFTKKG-AITEKEINQIVEKTRNTGFE-LLELL 235
Query: 246 GAESSTLAMAWSINEFIDIILDAILGYRVVVNCYTANSNFGTK-FFAG-PTSVGPHGI 301
S A + +I E I+ L + RV+V N ++G K FAG P +G GI
Sbjct: 236 PEGSVCFAPSLAIVEIIEAYLKDL--KRVLVCSVLLNGHYGHKGVFAGIPVVIGGKGI 291
>UniRef50_P62056 Cluster: L-lactate dehydrogenase; n=2;
Bacteria|Rep: L-lactate dehydrogenase - Treponema
denticola
Length = 315
Score = 56.4 bits (130), Expect = 1e-06
Identities = 48/187 (25%), Positives = 92/187 (49%), Gaps = 11/187 (5%)
Query: 21 LQKRNVQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRI-KGTELEL-SNLPGGPS 78
+ ++ +V+V+GA + +GS + L ++ ++ + D + +G L+L LP P
Sbjct: 1 MDEKKRKVTVVGAGA-VGSTFAYALAQSGYADEIAITDMNKNFAEGQALDLVQGLPFLPQ 59
Query: 79 VSAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAF 138
V GD + A S++VV+ + ++ G TR +L NA +I + K IA
Sbjct: 60 VDIHAGDKT-DYA--DSDIVVVTAGAKQQSGETRIDLLKRNASIITGIAKDIAESGCSGV 116
Query: 139 VAISTNPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVP 197
+ I +NP++ L + K + ++ G T +DT+R R ++K ++A+ I
Sbjct: 117 MLIVSNPVDIL----TRAALKASGWERGRVIGSGTVLDTARFRYTLSKECGVDARNIHGY 172
Query: 198 VIGGHSD 204
++G H D
Sbjct: 173 ILGEHGD 179
>UniRef50_Q6F0L9 Cluster: L-lactate dehydrogenase; n=6;
Mollicutes|Rep: L-lactate dehydrogenase - Mesoplasma
florum (Acholeplasma florum)
Length = 317
Score = 56.4 bits (130), Expect = 1e-06
Identities = 29/114 (25%), Positives = 63/114 (55%), Gaps = 5/114 (4%)
Query: 95 SNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPINYLIPFAS 154
++L+V+ + P++PG TR +++ N+ +++ + +AI A I++NP + L +
Sbjct: 74 ADLIVITAGRPQRPGETRLELIADNSRIMKGIAEAIKASGFNGVTVIASNPCDVL----T 129
Query: 155 TVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHSDKTI 207
TV + Y+ + G T +D++R R VA+ L + + + ++G H D ++
Sbjct: 130 TVYQQVTGYDEHSVVGAGTTLDSARLRRLVAEKLNVAPKSVNAYIMGEHGDSSV 183
>UniRef50_Q98PG4 Cluster: L-lactate dehydrogenase; n=1; Mycoplasma
pulmonis|Rep: L-lactate dehydrogenase - Mycoplasma
pulmonis
Length = 315
Score = 56.0 bits (129), Expect = 1e-06
Identities = 33/121 (27%), Positives = 64/121 (52%), Gaps = 6/121 (4%)
Query: 95 SNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPINYLIPFAS 154
++L+++ + P+K G TR +M+ N+ +++ + I F + +NP++ L +
Sbjct: 71 ADLLIVAAGRPQKQGETRLEMIADNSKIMKDIALEIKKSGFNGFTIVISNPVDIL----A 126
Query: 155 TVMYKYGCYNPSK-MFGITHIDTSRSRSFVAKALKINAQEIQVPVIGGHSDKTIIPLFSN 213
TV K + K M T +DTSR R F+++ + + VIG H DK+++ +FS
Sbjct: 127 TVFQKVTNFPKEKVMSSGTFLDTSRFRKFLSEKTGVPTNSVHGFVIGEHGDKSVV-VFSR 185
Query: 214 L 214
+
Sbjct: 186 M 186
>UniRef50_A0LRV1 Cluster: Lactate/malate dehydrogenase; n=3;
Actinomycetales|Rep: Lactate/malate dehydrogenase -
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Length = 330
Score = 55.2 bits (127), Expect = 2e-06
Identities = 32/121 (26%), Positives = 63/121 (52%), Gaps = 4/121 (3%)
Query: 90 QAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPINYL 149
+ I +++V++ + +PRKPG +R +L NA +++ + + IA A V + +NP++ +
Sbjct: 83 EVIADASIVIITAGVPRKPGMSRMDLLETNARIVRGVAENIAKYAPSAVVIVVSNPLDEM 142
Query: 150 IPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEIQVPVIGGHSDKTIIP 209
V G M +DT+R FVA+ L + + ++ +G H D T++P
Sbjct: 143 TALTQLVT---GFPKNRVMGQAGMLDTARFSHFVAEELGVPIRAVRTLTLGSHGD-TMVP 198
Query: 210 L 210
+
Sbjct: 199 V 199
>UniRef50_Q86S08 Cluster: NAD-specific malate dehydrogenase 1; n=2;
Entamoeba histolytica|Rep: NAD-specific malate
dehydrogenase 1 - Entamoeba histolytica
Length = 355
Score = 55.2 bits (127), Expect = 2e-06
Identities = 58/252 (23%), Positives = 115/252 (45%), Gaps = 24/252 (9%)
Query: 21 LQKRNVQVSVIGAASDIGSYVSLFLKRN------SKVSKLHLYDDD-DRIKGTELELSNL 73
++ + + V V GAA IG Y LFL + ++ LHLYD + ++G ++EL++
Sbjct: 20 VESKPLHVLVTGAAGQIG-YNLLFLIAHGLMFGPNQTVYLHLYDIMVEAMEGVKMELADC 78
Query: 74 PGGPSVSAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIA-A 132
P V + E A ++V+ MPRK G R++++G N +++ A+
Sbjct: 79 CF-PLVKGVVASNKTEVAFKDVECAILVAGMPRKVGMERKELIGINTRIMKEQALALKNF 137
Query: 133 QNQEAFVAISTNPINYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQ 192
N V + NP N + V+ + ++ +T +D +R+ + +A L +
Sbjct: 138 ANPHVRVLVVANPAN----TNALVVANNAGIDVKQITCLTRLDQNRAIAQIASKLNCKVE 193
Query: 193 EIQVPVI-GGHSDKTIIPLFSNL---TPRNYR-----IEPCQADMLTRLVRKAGTEVVMH 243
++ + G HS+K P S+ TP + +E + + V++ G +V+
Sbjct: 194 DVSDAFVWGNHSEKQ-CPDISHAVVQTPNGPKRVADLVEESWLESFNKTVQERGAKVIEM 252
Query: 244 KHGAESSTLAMA 255
+ + +++ A A
Sbjct: 253 RKASSAASAAKA 264
>UniRef50_Q03BE6 Cluster: L-lactate dehydrogenase; n=1;
Lactobacillus casei ATCC 334|Rep: L-lactate
dehydrogenase - Lactobacillus casei (strain ATCC 334)
Length = 312
Score = 54.8 bits (126), Expect = 3e-06
Identities = 28/110 (25%), Positives = 60/110 (54%), Gaps = 3/110 (2%)
Query: 95 SNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPINYLIPFAS 154
++++V+ + + +KPG TR Q+L NA +++ + I A F+ +++NP++ L A
Sbjct: 72 ADIIVITAGIAQKPGQTRLQLLAINAKIMKEITHNIMASGFNGFILVASNPVDVL---AE 128
Query: 155 TVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEIQVPVIGGHSD 204
V+ + G + T +D++R RS + ++A+ + ++G H D
Sbjct: 129 LVLQESGLPRNQVLGSGTALDSARLRSEIGLRYNVDARIVHGYIMGEHGD 178
>UniRef50_A2SNY0 Cluster: Malate/lactate dehydrogenases-like
protein; n=1; Methylibium petroleiphilum PM1|Rep:
Malate/lactate dehydrogenases-like protein - Methylibium
petroleiphilum (strain PM1)
Length = 432
Score = 54.8 bits (126), Expect = 3e-06
Identities = 48/220 (21%), Positives = 98/220 (44%), Gaps = 10/220 (4%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIK-GTELELSNLPGGPSVSAFIGD 85
+ V+GA +G+ +L L + S++ L D + G L++ + G S +
Sbjct: 125 KAGVVGAGH-VGAMTALRLAESDLFSEVALVDVVPGLAAGLALDMWHGAGLYGFSTRLSG 183
Query: 86 TNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNP 145
++ A+ + +V+ + PR+PG +R + NA ++ +C+ I + + I +NP
Sbjct: 184 SDDLVALAGAEYIVITAGKPRQPGMSRTDLTVVNAEIMTSVCRGIRTHAPNSTLVIVSNP 243
Query: 146 INYLIPFASTVMYKYGCYNPSKMFGITHI-DTSRSRSFVAKALKINAQEIQVPVIGGHSD 204
+ + A+ + + ++ G+ + D++R + V K QE++ +G H
Sbjct: 244 LEEMTHLAA----QQTGFPEERVLGMAGVLDSARFCALVGLTGKARPQEVRAVALGSHGP 299
Query: 205 KTIIPL---FSNLTPRNYRIEPCQADMLTRLVRKAGTEVV 241
+ +IPL F P + L R++G EVV
Sbjct: 300 EMVIPLSQAFVGDRPIESMFDAETLKALVERARESGGEVV 339
>UniRef50_Q838C9 Cluster: L-lactate dehydrogenase 2; n=9;
Bacilli|Rep: L-lactate dehydrogenase 2 - Enterococcus
faecalis (Streptococcus faecalis)
Length = 317
Score = 54.4 bits (125), Expect = 4e-06
Identities = 43/187 (22%), Positives = 95/187 (50%), Gaps = 12/187 (6%)
Query: 25 NVQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYD-DDDRIKGTELELSNLP--GGPSVSA 81
N +V++IG +G+ ++ + ++L L D D + +G ++L + G +V+
Sbjct: 5 NKKVAIIGTGF-VGTSIAYSMINQGIANELILVDIDKAKSEGEAIDLLDGVSWGQENVNV 63
Query: 82 FIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAI 141
+ GD Q +++VV+ + +KPG +R ++ NA +++ + I + + I
Sbjct: 64 WAGDY---QDCQDADIVVITAGANQKPGQSRLDLVSINAEIMKTIVNNIMKSGFDGILVI 120
Query: 142 STNPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIG 200
++NP++ L + V ++ S++ G T +DT+R R +++ L I+ + + +IG
Sbjct: 121 ASNPVDVL----TYVAWQASGLPVSRVIGTGTTLDTTRFRKELSQRLAIDPRNVHGYIIG 176
Query: 201 GHSDKTI 207
H D +
Sbjct: 177 EHGDSEV 183
>UniRef50_P19869 Cluster: L-lactate dehydrogenase 2; n=17;
Bacteria|Rep: L-lactate dehydrogenase 2 -
Bifidobacterium longum
Length = 320
Score = 54.4 bits (125), Expect = 4e-06
Identities = 43/192 (22%), Positives = 98/192 (51%), Gaps = 11/192 (5%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYD-DDDRIKGTELELSNLPGG-PSVSAFIG 84
+++VIGA + +GS ++ + ++ L D +R++ L++ + P+VS I
Sbjct: 10 KLAVIGAGA-VGSTLAFAAAQRGIAREIVLEDIAKERVEAEVLDMQHGSSFYPTVS--ID 66
Query: 85 DTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTN 144
++ + +++VV+ + +KPG +R +++GA +++ + + A + TN
Sbjct: 67 GSDDPEICRDADMVVITAGPRQKPGQSRLELVGATVNILKAIMPNLVKVAPNAIYMLITN 126
Query: 145 PINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHS 203
P++ A+ V K +++FG T++D++R R +A+ +N + + + G H
Sbjct: 127 PVD----IATHVAQKLTGLPENQIFGSGTNLDSARLRFLIAQQTGVNVKNVHAYIAGEHG 182
Query: 204 DKTIIPLFSNLT 215
D +PL+ + T
Sbjct: 183 DSE-VPLWESAT 193
>UniRef50_Q87JV1 Cluster: Lactate dehydrogenase; n=4; Vibrio|Rep:
Lactate dehydrogenase - Vibrio parahaemolyticus
Length = 317
Score = 54.0 bits (124), Expect = 5e-06
Identities = 79/319 (24%), Positives = 137/319 (42%), Gaps = 25/319 (7%)
Query: 26 VQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDD-DRIKGTELELSN---LPGGPSVSA 81
+++ VIGA + +G V +L VS+L L D + +R +G + + L +
Sbjct: 1 MKIGVIGAGA-VGVGVCNYLLTLGSVSELVLLDQNLERAEGEVFDFRHTAALTFSKNTRI 59
Query: 82 FIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAI 141
D L+ + +++VV+ + + G TR + NA + + + I +A + +
Sbjct: 60 IPSDDYLD--LLGADIVVITAGAQIQQGQTRLDIAEINAKIGVEIARKIERVAPKAVLIV 117
Query: 142 STNPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIG 200
+NP + + F +T G + P+K+ IDT+R S VA + ++ + I V+G
Sbjct: 118 VSNPCDIVAHFITT---NTG-FEPNKVISSGCVIDTARLMSIVANRVDLDPKNIFGYVLG 173
Query: 201 GHSDKTIIP--LFSNL-TPRNY-----RIEPCQADMLTRLVRKAGTEVVMHKHGAESSTL 252
H P L S P +Y IE AD L V++AG E+ KH
Sbjct: 174 EHGSHCFTPKSLISIAGQPADYYCDTHNIERIDADELLEAVKQAGYEIFRRKHNTVHGIA 233
Query: 253 AMAWSINEFIDIILDAILGYRVVVNCYTANSNFGTKFFAGPTSVGPHGIIQACCHFPMSE 312
A + I + I I ++L +++ S + PT VG G H P +E
Sbjct: 234 ASVFRIIQAIKINERSVLPVGTMMSGQYGVSGV---VLSLPTVVGKKGAESVLTH-PFTE 289
Query: 313 FESYLLNRCIPILSREVLE 331
E L+ I + R ++E
Sbjct: 290 EELETLH-SISMNLRSIVE 307
>UniRef50_A6M0Q2 Cluster: L-lactate dehydrogenase; n=1; Clostridium
beijerinckii NCIMB 8052|Rep: L-lactate dehydrogenase -
Clostridium beijerinckii NCIMB 8052
Length = 316
Score = 54.0 bits (124), Expect = 5e-06
Identities = 45/191 (23%), Positives = 87/191 (45%), Gaps = 9/191 (4%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTEL-ELSNLPGGPSVSAFIGD 85
+V ++G S +G+ V+ + N L L D + E +L + G + D
Sbjct: 7 KVVIVGTGS-VGAAVAFDMVMNHVCDDLILIDINKEKSWAEATDLQHSLGYSGSKMRVKD 65
Query: 86 TNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNP 145
E+ + +++VV+ + +P G TR ML A ++ + I + + TNP
Sbjct: 66 GEYEEC-NDADIVVIAAALPYITGQTRLDMLEKAAGIMNNIVPNIMKSGFSGIIVVITNP 124
Query: 146 INYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHSD 204
++ + S ++K SK+ G T +D++R + +A + ++ Q + +G H D
Sbjct: 125 VDVM----SYYVHKLSGLPASKVIGTGTALDSARLKYHLADVMSVDPQSVHALCMGEHGD 180
Query: 205 KTIIPLFSNLT 215
IIP +S +T
Sbjct: 181 SQIIP-WSQIT 190
>UniRef50_Q4A0K7 Cluster: Lactate dehydrogenase; n=1; Staphylococcus
saprophyticus subsp. saprophyticus ATCC 15305|Rep:
Lactate dehydrogenase - Staphylococcus saprophyticus
subsp. saprophyticus (strain ATCC 15305 /DSM 20229)
Length = 310
Score = 52.8 bits (121), Expect = 1e-05
Identities = 64/287 (22%), Positives = 126/287 (43%), Gaps = 19/287 (6%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDD-DRIKGTELELSNLPGGPSVSAFIGD 85
++ +IG +G+ V +++ + S++ L DD D G L+ + G + +
Sbjct: 3 KLGIIGLGK-VGTQVLTDVQQLNLFSEIILIDDRADVASGEALDHIHSQGLINTAHIKIR 61
Query: 86 TNLEQAIHSSNLVVMV-SRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTN 144
+ + Q + ++ +V+ S K R + N +I+ + IA QEA V + +N
Sbjct: 62 SGVYQDLTDADFIVIAASEATDKNNGDRTLLAQGNHDIIKGIMSQIAEVTQEAVVILISN 121
Query: 145 PINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHS 203
P++ ++ FA+ + Y K+ G T ++TSR ++ +A +I+ ++ VIG H
Sbjct: 122 PVDSMVYFANQIDYP-----AHKIIGTGTALETSRFKTIIADHYQIDPNNVEAFVIGEHG 176
Query: 204 DKTIIPLFSNLTPRNYRIEPCQADMLTRLVRKAG-----TEVVMHKHGAESSTLAMAWSI 258
IP++S + + +A + K+ EV M + T A +
Sbjct: 177 QHA-IPVWSKVHIHGMELSEFEALSDRPAIDKSHISSIINEVSMDVFYQKGWTNAAISKV 235
Query: 259 NEFIDIILDAILGYRVVVNCYTANSNFGTK--FFAGPTSVGPHGIIQ 303
F +I L R + + +S +G + F+ PT + GI+Q
Sbjct: 236 TSF--LIQSIALDQRTITPLTSLSSEYGLEDGAFSLPTLIDKKGIVQ 280
>UniRef50_P20619 Cluster: L-lactate dehydrogenase X; n=14;
Bacillales|Rep: L-lactate dehydrogenase X - Bacillus
psychrosaccharolyticus
Length = 319
Score = 52.4 bits (120), Expect = 2e-05
Identities = 46/197 (23%), Positives = 100/197 (50%), Gaps = 16/197 (8%)
Query: 23 KRNV-QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYD-DDDRIKGTELELSN---LPGGP 77
+RN+ +V++IGA S +GS + L S +L + D ++D+ G ++L++ P
Sbjct: 3 QRNINRVALIGAGS-VGSSYAFALLNQSITEELVIIDVNEDKAMGDAMDLNHGKIFAPNP 61
Query: 78 SVSAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEA 137
+ + + + ++A ++V + + +KPG TR ++ N + + L + A +
Sbjct: 62 TKTWYGNYDDCKEA----DIVCICAGANQKPGETRLDLVEKNLKIFKSLVDQVMASGFDG 117
Query: 138 FVAISTNPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQV 196
I+TNP++ ++ +A+ +K+ ++ G T +D+ R R + + I +
Sbjct: 118 IFLIATNPVD-ILTYAT---WKFSGLPKERVIGSGTILDSGRFRFLLGEYFDIAPANVHA 173
Query: 197 PVIGGHSDKTIIPLFSN 213
+IG H D T +P++S+
Sbjct: 174 HIIGEHGD-TELPVWSH 189
>UniRef50_Q4SRH5 Cluster: L-lactate dehydrogenase; n=4;
Euteleostomi|Rep: L-lactate dehydrogenase - Tetraodon
nigroviridis (Green puffer)
Length = 360
Score = 51.6 bits (118), Expect = 3e-05
Identities = 45/206 (21%), Positives = 96/206 (46%), Gaps = 9/206 (4%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDD-DDRIKGTELELSNLPGGPSVSAFIGD 85
+V+V+G +G ++ + +L L D +DR+KG ++L + S + D
Sbjct: 23 KVTVVGVGQ-VGMACAISILLRDLADELALVDVMEDRLKGELMDLQHGSLFLKTSKIVAD 81
Query: 86 TNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNP 145
+ +S LVV+ + + ++ G +R ++ N + + + I + + + +NP
Sbjct: 82 KDYSVTANS-RLVVVTAGVRQQEGESRLNLVQRNVNVFKSIIPQIIKYSPNCTLIVVSNP 140
Query: 146 INYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHSD 204
++ L + V +K ++ G T++D++R R +A+ L I+A V+G H D
Sbjct: 141 VDVL----TYVTWKLSGLPKHRVIGSGTNLDSARFRYLMAERLGIHASSFNGWVLGEHGD 196
Query: 205 KTIIPLFSNLTPRNYRIEPCQADMLT 230
T +P++S ++ D+ T
Sbjct: 197 -TSVPVWSGANVAGVNLQKLNPDIGT 221
>UniRef50_Q2S4R2 Cluster: L-lactate dehydrogenase; n=1; Salinibacter
ruber DSM 13855|Rep: L-lactate dehydrogenase -
Salinibacter ruber (strain DSM 13855)
Length = 316
Score = 51.6 bits (118), Expect = 3e-05
Identities = 44/199 (22%), Positives = 94/199 (47%), Gaps = 13/199 (6%)
Query: 20 ILQKRNVQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELSNLPGGPSV 79
++Q+R V ++G + +G+ + + S S++ L D D R E E +L G +
Sbjct: 1 MIQRRTV--GIVGTGN-VGTAAAYAMFNQSLASEILLLDQDTR--RAEGEAMDLMHGQQL 55
Query: 80 SAFIGDTNLEQAIHSSNLVVMVSR--MPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEA 137
I +E A S+ ++++S + P TR +L NA + + + + A
Sbjct: 56 VGGITCRAVEYAALSNAQIIVLSAGASQQSPDETRLGLLQRNAEIFREIIIQLDKHAPNA 115
Query: 138 FVAISTNPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQV 196
+ ++TNP++ L + + + ++ G T +DT+R R+ + + ++ + +
Sbjct: 116 ILVVATNPVDVL----TYICQELSSRPNRRILGTGTLLDTARFRALLGRHYGVDPRSVHA 171
Query: 197 PVIGGHSDKTIIPLFSNLT 215
++G H D +P++SN T
Sbjct: 172 YILGEHGDSE-VPIWSNAT 189
>UniRef50_Q7NG49 Cluster: L-lactate dehydrogenase; n=4;
Cyanobacteria|Rep: L-lactate dehydrogenase - Gloeobacter
violaceus
Length = 330
Score = 51.6 bits (118), Expect = 3e-05
Identities = 42/189 (22%), Positives = 92/189 (48%), Gaps = 10/189 (5%)
Query: 26 VQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDR-IKGTELELSNLPGGPSVSAFIG 84
++ +++GA + +G ++ + + +L L D D R ++G ++L + G P V +
Sbjct: 21 IKGAIVGAGA-VGMAIAYSMLIQNTFDELVLVDIDRRKVEGEVMDLVH--GIPFVEPSVV 77
Query: 85 DTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTN 144
++VV+ + ++ G TR ++ N + + L I A + + +N
Sbjct: 78 RAGTLADCRGVDVVVITAGARQREGETRLSLVQRNVEIFRGLIGEIMEHCPNAILLVVSN 137
Query: 145 PINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHS 203
P++ + + V K PS++ G T +DT+R R +A+ L+++ + + +IG H
Sbjct: 138 PVDVM----TYVAMKLAGLPPSRVIGSGTVLDTARFRYLLAERLRVDPRSLHAYIIGEHG 193
Query: 204 DKTIIPLFS 212
D +P++S
Sbjct: 194 DSE-VPVWS 201
>UniRef50_Q1FID3 Cluster: L-lactate dehydrogenase precursor; n=1;
Clostridium phytofermentans ISDg|Rep: L-lactate
dehydrogenase precursor - Clostridium phytofermentans
ISDg
Length = 325
Score = 51.2 bits (117), Expect = 4e-05
Identities = 27/116 (23%), Positives = 57/116 (49%), Gaps = 5/116 (4%)
Query: 95 SNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPINYLIPFAS 154
+++VV+ + P KPG +R LG +A ++ + + + + TNP++ + +
Sbjct: 76 ADIVVITAGPPPKPGQSRLDTLGLSADIVSTIVEPVMKSGFNGIFLVVTNPVDSIAQY-- 133
Query: 155 TVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHSDKTIIP 209
+Y+ ++ G T ID++R + F+ L ++ + IQ +G H D + P
Sbjct: 134 --VYQLSGLPKQQVLGTGTAIDSARLKHFIGDILHVDPRSIQAYTMGEHGDSQMCP 187
>UniRef50_A5Z9B1 Cluster: Putative uncharacterized protein; n=1;
Eubacterium ventriosum ATCC 27560|Rep: Putative
uncharacterized protein - Eubacterium ventriosum ATCC
27560
Length = 312
Score = 51.2 bits (117), Expect = 4e-05
Identities = 46/200 (23%), Positives = 93/200 (46%), Gaps = 11/200 (5%)
Query: 25 NVQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDD-DRIKGTELELSNLPGGPSVSAFI 83
N ++ +IGA +GS+ + L ++ L D D + K +++++ + S +
Sbjct: 4 NRKIVIIGAGH-VGSHCAYALAIQGICDEIVLVDKDRTKAKSHSMDIADSVSFFNSSVIV 62
Query: 84 GDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAIST 143
+ ++++V+ + +PR PG TR +L + ++ + + + + T
Sbjct: 63 RCGDYSDC-KDADIIVISAGVPRLPGQTRLDVLDGSVECVRDIVSNLNKIEIKGIIITIT 121
Query: 144 NPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGH 202
NP + + F + K +++F T +DT+R R VA I Q + +G H
Sbjct: 122 NPADIIADF----VRKATGLPKNRVFSTGTSLDTARMRRTVADLCNIAPQSVIGFAMGEH 177
Query: 203 SDKTIIPLFSNLT--PRNYR 220
D +++P FSNLT +NY+
Sbjct: 178 GDSSMVP-FSNLTIFGKNYK 196
>UniRef50_P47698 Cluster: L-lactate dehydrogenase; n=2;
Mycoplasma|Rep: L-lactate dehydrogenase - Mycoplasma
genitalium
Length = 312
Score = 51.2 bits (117), Expect = 4e-05
Identities = 28/112 (25%), Positives = 58/112 (51%), Gaps = 5/112 (4%)
Query: 97 LVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPINYLIPFASTV 156
+ + R ++ G TR Q+L N +++ + K I I++NP++ + S
Sbjct: 75 IFISAGRPQKQGGETRLQLLEGNVEIMKSIAKEIKKSGFNGVTLIASNPVDIM----SYT 130
Query: 157 MYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHSDKTI 207
K + P+K+ G T +D++R R +A +++++++Q VIG H D ++
Sbjct: 131 YLKVTGFEPNKVIGSGTLLDSARLRYAIATKYQMSSKDVQAYVIGEHGDSSV 182
>UniRef50_P0C0J4 Cluster: L-lactate dehydrogenase; n=5; Mycoplasma
hyopneumoniae|Rep: L-lactate dehydrogenase - Mycoplasma
hyopneumoniae
Length = 315
Score = 50.8 bits (116), Expect = 5e-05
Identities = 30/125 (24%), Positives = 63/125 (50%), Gaps = 8/125 (6%)
Query: 92 IHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPINYLIP 151
+ ++ +V+ + P+KPG TR +++ N +I+ + + I NP++ +
Sbjct: 69 LKDADFIVITAGRPQKPGETRLELVADNIRIIREIALKVKESGFSGISIIVANPVDII-- 126
Query: 152 FASTVMYKYGC-YNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHSDKTIIP 209
T Y+ ++ K+ G T +DT+R + +AK K++ +Q V+G H D + +
Sbjct: 127 ---TRAYRDASGFSDQKVIGSGTVLDTARLQFAIAKRAKVSPNSVQAYVMGEHGDSSFV- 182
Query: 210 LFSNL 214
+SN+
Sbjct: 183 AYSNI 187
>UniRef50_UPI0000519EC7 Cluster: PREDICTED: similar to
Ecdysone-inducible gene L3 CG10160-PA; n=2;
Apocrita|Rep: PREDICTED: similar to Ecdysone-inducible
gene L3 CG10160-PA - Apis mellifera
Length = 409
Score = 50.4 bits (115), Expect = 7e-05
Identities = 28/122 (22%), Positives = 62/122 (50%), Gaps = 6/122 (4%)
Query: 94 SSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPINYLIPFA 153
+S ++V+ + + G +R ++ N+ +++ + + + A + + +NP++ L
Sbjct: 164 NSKVIVLAAGARQMKGESRLDLVQRNSEILKSIIPTLVGYSPNAVILVVSNPVDIL---- 219
Query: 154 STVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHSDKTIIPLFS 212
S + +K S++ G TH+D++R R +A L I + +IG H D +PL+S
Sbjct: 220 SWLTWKISGLPASRVIGTGTHVDSARFRFLIADRLGIAPSSVHATIIGEHGDSQ-VPLWS 278
Query: 213 NL 214
+
Sbjct: 279 GV 280
>UniRef50_Q4UJ29 Cluster: L-lactate dehydrogenase, putative; n=2;
Theileria|Rep: L-lactate dehydrogenase, putative -
Theileria annulata
Length = 367
Score = 50.0 bits (114), Expect = 9e-05
Identities = 31/105 (29%), Positives = 59/105 (56%), Gaps = 6/105 (5%)
Query: 112 REQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPINYLIPFASTVMYKYGCYNPSKMFGI 171
R+ ++G N+ +I+ + + I EAFV + TNP++ ++ +M K + + + G+
Sbjct: 143 RDDLVGYNSKIIRDVGENIKKYAPEAFVIVITNPMDVMVH----LMLKVTGFPKNMVVGM 198
Query: 172 THI-DTSRSRSFVAKALKINAQEIQVPVIGGHSDKTIIPLFSNLT 215
+ D+SR ++A+ L +N + + VIG H D ++IPL S T
Sbjct: 199 GGLLDSSRMNCYIAEKLGVNPKYVHGSVIGAHGD-SMIPLVSRST 242
>UniRef50_UPI000023CE12 Cluster: hypothetical protein FG10444.1;
n=1; Gibberella zeae PH-1|Rep: hypothetical protein
FG10444.1 - Gibberella zeae PH-1
Length = 309
Score = 49.6 bits (113), Expect = 1e-04
Identities = 40/184 (21%), Positives = 83/184 (45%), Gaps = 8/184 (4%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELE-LSNLPGGPSVSAFIGD 85
+V+++G ++G V+ L NS S+L L D D + ++E LS++ + S +
Sbjct: 6 RVAIVGVG-EVGGAVAYNLTLNSMASELLLVDLDPSARNAQIEDLSDVTYSTNSSTRVRS 64
Query: 86 TNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNP 145
+A +LVV+ + G T N +++ + +A+ + + I +P
Sbjct: 65 ATYHEAAQC-DLVVITAASKHMLGQTTIDYTSRNTSMLRGVMEAMKPFRADTVLLIVADP 123
Query: 146 INYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHSD 204
++ L A + S++FG T +DT R R +A ++ + V+G H +
Sbjct: 124 VDLLTSLAKQM----SGLPESQVFGTGTALDTYRLRGMIASRALVSPYTVDAFVVGRHGE 179
Query: 205 KTII 208
+ ++
Sbjct: 180 EQVV 183
>UniRef50_O08349 Cluster: Malate dehydrogenase; n=1; Archaeoglobus
fulgidus|Rep: Malate dehydrogenase - Archaeoglobus
fulgidus
Length = 294
Score = 49.6 bits (113), Expect = 1e-04
Identities = 42/186 (22%), Positives = 88/186 (47%), Gaps = 11/186 (5%)
Query: 26 VQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYD-DDDRIKGTELELSNLPGG-PSVSAFI 83
+++ +GA +GS + N V ++ L D +D G ++L++ G +
Sbjct: 1 MKLGFVGAGR-VGSTSAFTCLLNLDVDEIALVDIAEDLAVGEAMDLAHAAAGIDKYPKIV 59
Query: 84 GDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAIST 143
G + + S ++V+ + + RKPG TR + NA +I+ + K I E+ + + T
Sbjct: 60 GGADYS-LLKGSEIIVVTAGLARKPGMTRLDLAHKNAGIIKDIAKKIVENAPESKILVVT 118
Query: 144 NPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGH 202
NP++ + + +M+K +++FG+ +D+ R + + A N + + +IG H
Sbjct: 119 NPMDVM----TYIMWKESGKPRNEVFGMGNQLDSQRLKERLYNAGARNIR--RAWIIGEH 172
Query: 203 SDKTII 208
D +
Sbjct: 173 GDSMFV 178
>UniRef50_Q9P4B6 Cluster: L-lactate dehydrogenase A; n=48; Rhizopus
oryzae|Rep: L-lactate dehydrogenase A - Rhizopus oryzae
(Rhizopus delemar)
Length = 320
Score = 49.2 bits (112), Expect = 2e-04
Identities = 36/183 (19%), Positives = 87/183 (47%), Gaps = 8/183 (4%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELSNLPGGPSVSAFIGDT 86
+V+++GA + +G+ + L + +++ + D + I + ++ +L S+S
Sbjct: 6 KVAIVGAGA-VGASTAYALMFKNICTEIIIVDVNPDI--VQAQVLDLADAASISHTPIRA 62
Query: 87 NLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPI 146
+ +++VV+ + ++ G R +++ N ++Q + + +A + + NP+
Sbjct: 63 GSAEEAGQADIVVITAGAKQREGEPRTKLIERNFRVLQSIIGGMQPIRPDAVILVVANPV 122
Query: 147 NYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHSDK 205
+ L A T+ P+++ G T++DT+R R + +N Q + V+G H D
Sbjct: 123 DILTHIAKTL----SGLPPNQVIGSGTYLDTTRLRVHLGDVFDVNPQSVHAFVLGEHGDS 178
Query: 206 TII 208
+I
Sbjct: 179 QMI 181
>UniRef50_UPI000038D9FF Cluster: COG0039: Malate/lactate
dehydrogenases; n=2; Nostoc punctiforme PCC 73102|Rep:
COG0039: Malate/lactate dehydrogenases - Nostoc
punctiforme PCC 73102
Length = 317
Score = 48.8 bits (111), Expect = 2e-04
Identities = 44/184 (23%), Positives = 81/184 (44%), Gaps = 7/184 (3%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDD-DRIKGTELELSNLPGGPSVSAFIGD 85
+V +IGA + +G+ V+ L + ++ L+D + +G ++ + I
Sbjct: 7 KVGIIGAGN-VGADVANALVLLGRCVRVVLFDRTLSKAEGQVWDIEDSIPLLKEMEIIPS 65
Query: 86 TNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNP 145
E S ++++ + + K G TR L NA +I+ K + + V I +NP
Sbjct: 66 NQYEDLADSDIIIIVTAGVQPKLGQTRLDTLSDNAEIIRSTIKELDRVAPNSIVIIISNP 125
Query: 146 INYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHSD 204
++ L A + + +FG T +DT+R R + K L + Q+I VIG H D
Sbjct: 126 VDVLTRIAQATSTR----AENLIFGSGTVLDTARLRYQLGKQLNVAKQDIHAYVIGEHGD 181
Query: 205 KTII 208
+
Sbjct: 182 SQFV 185
>UniRef50_A3DCA4 Cluster: L-lactate dehydrogenase precursor; n=2;
Clostridium|Rep: L-lactate dehydrogenase precursor -
Clostridium thermocellum (strain ATCC 27405 / DSM 1237)
Length = 318
Score = 48.8 bits (111), Expect = 2e-04
Identities = 41/193 (21%), Positives = 94/193 (48%), Gaps = 12/193 (6%)
Query: 23 KRNVQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDD-DDRIKGTELELSN-LPGGPSVS 80
K +V++IGA +G+ + + ++L L D ++ G +++++ LP +S
Sbjct: 5 KSRSKVAIIGAGF-VGASAAFTMALRQTANELVLIDVFKEKAIGEAMDINHGLPFMGQMS 63
Query: 81 AFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVA 140
+ GD + + +++V+ + RKPG TR + N + + + + I +
Sbjct: 64 LYAGDYS---DVKDCDVIVVTAGANRKPGETRLDLAKKNVMIAKEVTQNIMKYYNHGVIL 120
Query: 141 ISTNPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVI 199
+ +NP++ + + ++ K+ K+ G T +D+ R R +++ L ++ + + +I
Sbjct: 121 VVSNPVDII----TYMIQKWSGLPVGKVIGSGTVLDSIRFRYLLSEKLGVDVKNVHGYII 176
Query: 200 GGHSDKTIIPLFS 212
G H D +PL+S
Sbjct: 177 GEHGDSQ-LPLWS 188
>UniRef50_Q4L941 Cluster: L-lactate dehydrogenase; n=1;
Staphylococcus haemolyticus JCSC1435|Rep: L-lactate
dehydrogenase - Staphylococcus haemolyticus (strain
JCSC1435)
Length = 318
Score = 48.8 bits (111), Expect = 2e-04
Identities = 38/185 (20%), Positives = 90/185 (48%), Gaps = 12/185 (6%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYD-DDDRIKGTELELSNL-PGGPS-VSAFI 83
++ +IG+ +GS + + V ++ + D D+D+ K +L++ P G + V+ +
Sbjct: 5 KIVLIGSGY-VGSAFAHAIVAKGLVDEMAIIDIDEDKAKADVWDLNHATPFGDNFVNVHV 63
Query: 84 GDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAIST 143
G + +++VV+ + G TR ++L N + + + I + + + +
Sbjct: 64 GQY---EDFKDADIVVICASAKLAKGETRLKLLEDNVDIFVPMIQRIVDSGFDGYFVLPS 120
Query: 144 NPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGH 202
NP++ + S V+ + + +K+ G T +DT+R + F+++ + ++ P+IG H
Sbjct: 121 NPVDIM----SYVVKRVSNFPKNKIIGSGTSLDTARFQFFLSREFDVAPNQVYAPIIGEH 176
Query: 203 SDKTI 207
D +
Sbjct: 177 GDSQV 181
>UniRef50_Q64YY6 Cluster: Malate dehydrogenase; n=5;
Bacteroidales|Rep: Malate dehydrogenase - Bacteroides
fragilis
Length = 333
Score = 48.4 bits (110), Expect = 3e-04
Identities = 44/187 (23%), Positives = 82/187 (43%), Gaps = 9/187 (4%)
Query: 25 NVQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDD-DDRIKGTELELSNLPGGPSVSAFI 83
N +++++GAA IGS ++ + LYD ++G EL + +
Sbjct: 6 NEKLTIVGAAGMIGSNMAQTALMMKLTPNICLYDPYAPALEGVAEELYHCAFEGVNLTYT 65
Query: 84 GDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEA-FVAIS 142
D +++A+ + +V RK G TRE +L NA + + K I + V +
Sbjct: 66 SD--IKEALSGAKYIVSSGGAARKAGMTREDLLKGNAEIAAQFGKDIRQYCPDVKHVVVV 123
Query: 143 TNPINYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEI-QVPVIGG 201
NP + ++ Y PS++ + +D++R ++ + K L I A EI GG
Sbjct: 124 FNPAD----ITGLIVLLYAGLKPSQVSTLAALDSTRLQNELVKYLHIPASEIVNCRTYGG 179
Query: 202 HSDKTII 208
H ++ +
Sbjct: 180 HGEQMAV 186
>UniRef50_Q81XJ7 Cluster: L-lactate dehydrogenase 3; n=13;
Firmicutes|Rep: L-lactate dehydrogenase 3 - Bacillus
anthracis
Length = 316
Score = 48.4 bits (110), Expect = 3e-04
Identities = 44/236 (18%), Positives = 104/236 (44%), Gaps = 18/236 (7%)
Query: 21 LQKRNVQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYD-DDDRIKGTELELSNLPGGPSV 79
+++ ++++IG +GS + + +L L D + +R G ++LS+ +
Sbjct: 1 MKRHTRKIAIIGTGL-VGSSCAYSIVNQGICEELLLIDINHERAVGEAMDLSHCINFTNT 59
Query: 80 SAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFV 139
+ + E ++V++ + KPG +R LGA+A +++ + + +
Sbjct: 60 RTKVYAGSYEDC-KDMDIVIITAGPAPKPGQSRLDTLGASAKIMESVVGGVMESGFDGIF 118
Query: 140 AISTNPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPV 198
+++NP++ + + ++K +++ G T +D+SR R+ +++ L ++ + I
Sbjct: 119 LLASNPVDII----TYQVWKLSGLPRNRVIGTGTSLDSSRLRTILSEMLHVDPRSIHGYS 174
Query: 199 IGGHSDKTII----------PLFSNLTPRNYRIEPCQADMLTRLVRKAGTEVVMHK 244
+G H D ++ P+ L + R D + KAG E+ K
Sbjct: 175 LGEHGDSQMVAWSHVTVGGKPILQILEEQKERFGEIDLDEIVEKTAKAGWEIYKRK 230
>UniRef50_Q0PQR8 Cluster: Malate dehydrogenase NAD-dependent; n=1;
Endoriftia persephone 'Hot96_1+Hot96_2'|Rep: Malate
dehydrogenase NAD-dependent - Endoriftia persephone
'Hot96_1+Hot96_2'
Length = 170
Score = 48.0 bits (109), Expect = 4e-04
Identities = 32/134 (23%), Positives = 69/134 (51%), Gaps = 10/134 (7%)
Query: 113 EQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPINYLIPFASTVMYKYGCYNPSKMFGIT 172
+ +L N + +++ A+ +AFV ++TNP++ ++ +K ++ G+
Sbjct: 16 DDLLDINLSVTKKVATAVKQHAPDAFVILTTNPLDSIV----YAFHKLSGLPAERIIGMA 71
Query: 173 H-IDTSRSRSFVAKALKINAQEIQVPVIGGHSDKTIIPLFSNLTPRNYRI-EPCQADMLT 230
+DT+R R+++A ++ +++ V+GGH T+IP+ + + E + +
Sbjct: 72 GALDTARFRTYIAMETGLSVKDVSCLVMGGHG-PTMIPVTRTASVGGIPLTELLDQETIQ 130
Query: 231 RLV---RKAGTEVV 241
R+V R AGTE+V
Sbjct: 131 RIVERTRNAGTEIV 144
>UniRef50_Q4D123 Cluster: Malate dehydrogenase; n=9; Eukaryota|Rep:
Malate dehydrogenase - Trypanosoma cruzi
Length = 332
Score = 48.0 bits (109), Expect = 4e-04
Identities = 39/203 (19%), Positives = 87/203 (42%), Gaps = 10/203 (4%)
Query: 91 AIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIA-AQNQEAFVAISTNPINYL 149
A + ++ ++ P KPG R +L NA + + + +++ V + NP+N
Sbjct: 80 AFENVDIAILCGSFPAKPGTLRRDLLQKNAAIFSEHGRLLGELASKDCHVCVVGNPVN-- 137
Query: 150 IPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEIQVPVIGGHSDKTIIP 209
+ G P + +T +D +RS + VA+ + ++++ +I G+ T +P
Sbjct: 138 TNALVLLNASNGKIKPKNVSALTRLDHNRSLALVAERANAHVRDVKNCIIWGNHSGTQVP 197
Query: 210 LFSNLTPRNYRIEPCQAD------MLTRLVRKAGTEVVMHKHGAESSTLAMAWSINEFID 263
++ T + + D V++ G E++ + G S+ A ++++ D
Sbjct: 198 DVNSATVKGVPVREAIKDDAYLDGEFMTTVQQRGYEIIRWR-GNSSALSAANAAVDQVHD 256
Query: 264 IILDAILGYRVVVNCYTANSNFG 286
+L G V + Y+ + +G
Sbjct: 257 WVLGTPTGTHVSMAVYSDGNPYG 279
>UniRef50_Q7MTK2 Cluster: Malate dehydrogenase; n=4;
Bacteroidales|Rep: Malate dehydrogenase - Porphyromonas
gingivalis (Bacteroides gingivalis)
Length = 334
Score = 47.6 bits (108), Expect = 5e-04
Identities = 46/185 (24%), Positives = 81/185 (43%), Gaps = 9/185 (4%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDD-RIKGTELELSNLPGGPSVSAFIGD 85
+++++GAA IGS ++ L LYD ++G E+ + F D
Sbjct: 8 KLTIVGAAGMIGSNMAQTAAMMRLTPNLCLYDPFAVGLEGVAEEIRHCGFEGLNLTFTSD 67
Query: 86 TNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEA-FVAISTN 144
+++A+ + +V PRK G TRE +L NA + +L K I + + V I N
Sbjct: 68 --IKEALTDAKYIVSSGGAPRKEGMTREDLLKGNAEIAAQLGKDIKSYCPDCKHVIIIFN 125
Query: 145 PINYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEI-QVPVIGGHS 203
P + V Y PS++ + +D++R +S +AK I + GGH
Sbjct: 126 PAD----ITGLVTLIYSGLKPSQVTTLAGLDSTRLQSELAKHFGIKQSLVTNTRTYGGHG 181
Query: 204 DKTII 208
++ +
Sbjct: 182 EQMAV 186
>UniRef50_P62051 Cluster: L-lactate dehydrogenase; n=2;
Desulfovibrio vulgaris subsp. vulgaris|Rep: L-lactate
dehydrogenase - Desulfovibrio vulgaris (strain
Hildenborough / ATCC 29579 / NCIMB8303)
Length = 309
Score = 47.6 bits (108), Expect = 5e-04
Identities = 27/114 (23%), Positives = 57/114 (50%), Gaps = 5/114 (4%)
Query: 95 SNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPINYLIPFAS 154
+ +VV+ + + PG +R ++ NA + + + A+ + ++TNP++ L A
Sbjct: 69 ARIVVVTAGAKQMPGQSRLDLVRVNAGITRDILTAVMQYADDPLYIMATNPVDVLTHVAR 128
Query: 155 TVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHSDKTI 207
TV P ++ G T +D++R R VA+ L ++ + + ++G H D +
Sbjct: 129 TVT----GVAPGRVIGSGTVLDSARFRGHVAEILGVDVRGVHAHIVGEHGDSEV 178
>UniRef50_UPI00015BB1FC Cluster: malate dehydrogenase (NAD); n=1;
Ignicoccus hospitalis KIN4/I|Rep: malate dehydrogenase
(NAD) - Ignicoccus hospitalis KIN4/I
Length = 311
Score = 47.2 bits (107), Expect = 6e-04
Identities = 33/132 (25%), Positives = 64/132 (48%), Gaps = 7/132 (5%)
Query: 92 IHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPINYLIP 151
+ +++ +V+ + PRK +R + NA +I+ + + +N AF + TNP++ +
Sbjct: 72 VENADAIVITAGKPRKADMSRRDLAKVNAQIIRDIGDKLRDRNPGAFYMVITNPVDVMTM 131
Query: 152 FASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHSDKTIIPL 210
S V+ N + G T +DT R RS V++ L I V+G H ++ +
Sbjct: 132 ILSDVI-----GNKGTVIGTGTSLDTYRFRSAVSELLNEPIAAIDGYVVGEHGEEAFV-A 185
Query: 211 FSNLTPRNYRIE 222
+S +T + I+
Sbjct: 186 WSTVTVKGVPID 197
>UniRef50_Q6A6E3 Cluster: L-lactate dehydrogenase; n=1;
Propionibacterium acnes|Rep: L-lactate dehydrogenase -
Propionibacterium acnes
Length = 321
Score = 47.2 bits (107), Expect = 6e-04
Identities = 59/271 (21%), Positives = 112/271 (41%), Gaps = 23/271 (8%)
Query: 73 LPGGPSVSAFIGD----TNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCK 128
LP +V+ + GD +N + I ++ + S P G R ++ N +I+
Sbjct: 56 LPNVTNVAVYAGDYDDLSNADVIIMTAGPSIDASNGPAT-GAARRELAATNGKIIRSTMT 114
Query: 129 AIAAQNQEAFVAISTNPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKAL 187
I ++N +A + I +NP++ L+ AST + + G T +D++R VA L
Sbjct: 115 QITSRNHDAAIIICSNPLDALVHIASTEF----DHPQGLVLGTGTILDSARMCRVVADHL 170
Query: 188 KINAQEIQVPVIGGHSDKTIIPLFSNLT---------PRNYRIEPCQADMLTRLVRKAGT 238
++ ++ +IG H P+F+ + + + +P D LT + AGT
Sbjct: 171 GVDPDYVRGYMIGEHGPSG-FPMFTGVNVGGVGFDGLAKLFDADPMDRDELTTRINDAGT 229
Query: 239 EVVMHKHGAESSTLAMAWSINEFIDIILDAILGYRVVVNCYTANSNFGTKFFAGPTSVGP 298
V + G S+ + + +I I+L+ Y V + + G P +G
Sbjct: 230 -AVFNLKGWTSAGIGQS-AITIARSILLNEHAVYPVCTTLHGQYGHDGDVSMGVPCVIGA 287
Query: 299 HGIIQACCHFPMSEFESYLLNRCIPILSREV 329
G ++ P+ ++E L I + V
Sbjct: 288 TG-VERILEVPLDDWEQEHLASTIKAIQETV 317
>UniRef50_Q92BI0 Cluster: L-lactate dehydrogenase 2; n=18;
Bacteria|Rep: L-lactate dehydrogenase 2 - Listeria
innocua
Length = 311
Score = 47.2 bits (107), Expect = 6e-04
Identities = 44/189 (23%), Positives = 83/189 (43%), Gaps = 8/189 (4%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYD-DDDRIKGTELELSNLPGGPSVSAFIGD 85
+V +IGA + +GS + V +L L D + +R++G +L++ S I
Sbjct: 5 KVMIIGAGN-VGSAAAHAFVNQKFVEELILVDLNKERVEGNRKDLADAAAFMSGKMDISV 63
Query: 86 TNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNP 145
V+ V+ P K G TR L + + ++ + + + I+TNP
Sbjct: 64 REASDCADVDIAVITVTAGPLKEGQTRLDELRSTSRIVASIVPEMMKGGFKGIFLIATNP 123
Query: 146 INYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHSD 204
+ + + ++K ++ G +DT+R R +A+ L I AQ I ++G H D
Sbjct: 124 CDII----TYQVWKLSGLPREQVLGTGVWLDTTRLRRLLAEKLDIAAQSIDAFILGEHGD 179
Query: 205 KTIIPLFSN 213
P++S+
Sbjct: 180 SQ-FPVWSH 187
>UniRef50_A6NLX8 Cluster: L-lactate dehydrogenase; n=4;
Eutheria|Rep: L-lactate dehydrogenase - Homo sapiens
(Human)
Length = 253
Score = 46.8 bits (106), Expect = 8e-04
Identities = 41/191 (21%), Positives = 94/191 (49%), Gaps = 11/191 (5%)
Query: 27 QVSVIGAAS-DIGSYVSLFLKRNSKVSKLHLYD-DDDRIKGTELELSNLPGGPSVSAFIG 84
+VS+ G S + S+ LK S +L D D+ ++KG ++L + +S +
Sbjct: 71 KVSITGTGSVGMACATSILLKGLS--DELAFVDLDEGKLKGETMDLQHDSPFMKMSNIVC 128
Query: 85 DTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTN 144
+ + +LV++ + R+ G R ++ N + + + +I Q+ + I +N
Sbjct: 129 SKDY-LVTANPHLVIITAGARREKGEMRFNLVRQNVAIFKLMISSIVQQSPLCKLIIVSN 187
Query: 145 PINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHS 203
P++ L + V +K + +++ G ++DT R + F+ + L I+++ + ++G H
Sbjct: 188 PVDIL----TYVAWKLSAFPKNRVIGSGCNLDTVRFQFFIGQKLGIHSESCRGWILGEHG 243
Query: 204 DKTIIPLFSNL 214
D + +P++S +
Sbjct: 244 DSS-VPVWSGM 253
>UniRef50_A2G340 Cluster: Malate dehydrogenase; n=18;
Trichomonadinae|Rep: Malate dehydrogenase - Trichomonas
vaginalis G3
Length = 339
Score = 46.4 bits (105), Expect = 0.001
Identities = 40/193 (20%), Positives = 84/193 (43%), Gaps = 13/193 (6%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSK----LHLYD---DDDRIKGTELELSNLPGGPSV 79
+V + GAA IG +S ++ + LHL+D +R+ +EL + P +
Sbjct: 6 RVLITGAAGQIGYVLSHWIASGELYGERPVILHLFDIPVAQNRLTALTMELQDC-AFPHL 64
Query: 80 SAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAF- 138
+ ++ T EQA + +V+ +P K G R ++G+N+ + + + ++ +
Sbjct: 65 AGYVATTEPEQAFKDIDCAFLVASVPMKSGQIRSDLIGSNSIIFKNTGEWLSQYAKPTVK 124
Query: 139 VAISTNPINYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEI-QVP 197
V + NP N A + P ++ +D +R+ +A+ L + ++ +
Sbjct: 125 VLVIGNPDN---TNAEIALLHAKNLKPENFSSLSLLDQNRAYHAIAEKLGVKVTDLHDIV 181
Query: 198 VIGGHSDKTIIPL 210
V G H + + L
Sbjct: 182 VWGNHGESMVADL 194
>UniRef50_P50933 Cluster: L-lactate dehydrogenase; n=7;
Bacteria|Rep: L-lactate dehydrogenase - Deinococcus
radiodurans
Length = 304
Score = 46.4 bits (105), Expect = 0.001
Identities = 39/185 (21%), Positives = 82/185 (44%), Gaps = 11/185 (5%)
Query: 26 VQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYD-DDDRIKGTELELSNL-PGGPSVSAFI 83
++V V+G +GS + L S+L L D D+DR + ++++ P +
Sbjct: 1 MKVGVVGTGF-VGSTAAFALVLRGSCSELVLVDRDEDRAQAEAEDIAHAAPVSHGTRVWH 59
Query: 84 GDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAIST 143
G + + +V++ + +KPG +R +L NA + + L I +A + +++
Sbjct: 60 GG---HSELADAQVVILTAGANQKPGESRLDLLEKNADIFRELVPQITRAAPDAVLLVTS 116
Query: 144 NPINYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEIQVPVIGGHS 203
NP++ L A+ + T +D++R R +A+ ++ V+G H
Sbjct: 117 NPVDLLTDLATQLAPGQPVIGSG-----TVLDSARFRHLMAQHAGVDGTHAHGYVLGEHG 171
Query: 204 DKTII 208
D ++
Sbjct: 172 DSEVL 176
>UniRef50_Q97DC6 Cluster: L-lactate dehydrogenase 2; n=1;
Clostridium acetobutylicum|Rep: L-lactate dehydrogenase
2 - Clostridium acetobutylicum
Length = 320
Score = 46.4 bits (105), Expect = 0.001
Identities = 60/247 (24%), Positives = 118/247 (47%), Gaps = 31/247 (12%)
Query: 30 VIGAASDIGSYVSLFLKRNSKVSKLHLYD-DDDRIKGTELELSNLPG---GPSVSAFIGD 85
V+GA +GS V + + +S++ + D +D++ KG L+ S+ P+V G
Sbjct: 10 VVGAGM-VGSAVLNSVLSLNLLSEVVIIDINDNKAKGEALDASHTTSFAYSPNVKVRAG- 67
Query: 86 TNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGA--NAPLIQRLCKAIAAQNQEAFVAIST 143
N E + ++V+ + KP + ++++ A N + + K I ++A + + T
Sbjct: 68 -NYEDCA-DAQIIVITAGPSLKPDDKLDRLVLADTNVKVTDSIMKNICKYTKDAIIIVVT 125
Query: 144 NPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGH 202
NP++ A+ Y +K+ G T +DT+R R + K ++++ + V+G H
Sbjct: 126 NPVD----IATYYCQNNFDYPKNKIIGTGTLLDTARMRKIIGKKYNVDSKNVHGYVLGEH 181
Query: 203 --------SDKTI--IPL--FSNLTPRNYRIEPCQADMLTRLVRKAGTEVVMHKHGAESS 250
SD I IP +++ +Y+++ + D + VR +G EV+ K G S+
Sbjct: 182 GGSSFTSWSDVNIAGIPFNQLNDIFKDHYKVDKDEVD---KEVRDSGIEVLKLK-GYTSA 237
Query: 251 TLAMAWS 257
+AM+ S
Sbjct: 238 GIAMSVS 244
>UniRef50_A2Q223 Cluster: Lactate/malate dehydrogenase, alpha/beta
C-terminal domain containing protein; n=1; Medicago
truncatula|Rep: Lactate/malate dehydrogenase, alpha/beta
C-terminal domain containing protein - Medicago
truncatula (Barrel medic)
Length = 205
Score = 46.0 bits (104), Expect = 0.001
Identities = 22/58 (37%), Positives = 37/58 (63%), Gaps = 3/58 (5%)
Query: 185 KALKINAQEIQVPVIGGHSDKTIIPLFSNL-TPRNYRIEPCQADMLTRLVRKAGTEVV 241
+ L ++ +E+ VPV+GGH+ TI+PL S +P ++ E + + LT ++ GTEVV
Sbjct: 27 EVLGVDPREVDVPVVGGHAGVTILPLLSQAKSPSSFTAE--ETEYLTNRIQNGGTEVV 82
>UniRef50_A2E124 Cluster: Malate dehydrogenase; n=6;
Trichomonadidae|Rep: Malate dehydrogenase - Trichomonas
vaginalis G3
Length = 332
Score = 46.0 bits (104), Expect = 0.001
Identities = 72/308 (23%), Positives = 123/308 (39%), Gaps = 26/308 (8%)
Query: 26 VQVSVIGAASDIGSYVSLFLKRNSKVSK-----LHLYDDDDRIKGTELELSNLPGG--PS 78
+ V V GAA IG YV F N + LHL + +K E + L P
Sbjct: 5 LHVLVTGAAGQIG-YVLAFRIANGDLFGERDVVLHLLEISPAMKALEAVVMELHDCTFPH 63
Query: 79 VSAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIA-AQNQEA 137
+ IG ++LE+A ++ +V P+KP NA + +A++
Sbjct: 64 LLHVIGTSDLEEAFRDVDVAFLVGSFPKKPSTKLVDYFQRNASIYSEHGRALSDFAKPTV 123
Query: 138 FVAISTNPINYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEIQVP 197
V + P N A T +P +T +D +R+ +A+ L ++ ++
Sbjct: 124 KVLVIGMPTNTNALVAMTAAVN---LSPKNFCAMTRLDHNRAVYSIAQKLGVHHSKVYKV 180
Query: 198 VIGGHSDKTIIPLFSNL-----TPRNYRIEPCQADML----TRLVRKAGTEVVMHKHGAE 248
VI G+ + IP SN T R++ +E + + + + + G +V M + GA
Sbjct: 181 VIWGNRSSSQIPDVSNAEYQDETGRHHILEKVSEEYVNTEFSSDLAQRGNKVTMMR-GAS 239
Query: 249 SSTLAMAWSINEFIDIILDAILGYRVVVNCYTANSN-FGTK---FFAGPTSVGPHGIIQA 304
S+ A +I D + V ++ S+ +G K FF+ P +V G I
Sbjct: 240 SAASAATAAIQCMRDWLYGTPADNFVSMSVPVPESSPYGVKPGIFFSFPCTVDKEGNIHV 299
Query: 305 CCHFPMSE 312
P+ E
Sbjct: 300 VEGLPVDE 307
>UniRef50_Q92AZ3 Cluster: Lin1775 protein; n=13; Listeria|Rep:
Lin1775 protein - Listeria innocua
Length = 302
Score = 45.6 bits (103), Expect = 0.002
Identities = 45/185 (24%), Positives = 90/185 (48%), Gaps = 10/185 (5%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDD-DDRIKGTELELSNLPGGPSVSAFIGD 85
+V +IGA +GS V+ L ++ + D + + + LEL ++ I
Sbjct: 4 KVGIIGAGH-VGSDVAFSLVTQGICDEIVIIDKIEAKAESEALELRDMASMTRSYTTI-T 61
Query: 86 TNLEQAIHSSNLVVM-VSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTN 144
N +A+ ++++VM V + E+++ + + + + K +A + FV I TN
Sbjct: 62 ANSWEALSDADIIVMAVGPETLLREDRMEELVETSRSVTEIVPKILATGFKGIFVNI-TN 120
Query: 145 PINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHS 203
P + + + ++ K ++ S++FG T +DT+R R V +AL IN + I+ V+G H
Sbjct: 121 PCDVI----TMLIQKISGFDHSRVFGTGTSLDTARMRRVVGEALHINPKSIEGYVLGEHG 176
Query: 204 DKTII 208
+ +
Sbjct: 177 ESQFV 181
>UniRef50_Q27743 Cluster: L-lactate dehydrogenase; n=17;
Apicomplexa|Rep: L-lactate dehydrogenase - Plasmodium
falciparum (isolate CDC / Honduras)
Length = 316
Score = 45.6 bits (103), Expect = 0.002
Identities = 32/189 (16%), Positives = 93/189 (49%), Gaps = 13/189 (6%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIK-GTELELSNLPGGPSVSAFIGD 85
++ ++G+ G +L +++N + + L+D + G L+ S+ + +
Sbjct: 6 KIVLVGSGMIGGVMATLIVQKN--LGDVVLFDIVKNMPHGKALDTSHTNVMAYSNCKVSG 63
Query: 86 TNLEQAIHSSNLVVMVSRMPRKPGNT-----REQMLGANAPLIQRLCKAIAAQNQEAFVA 140
+N + +++V++ + + PG + R+ +L N ++ + I AF+
Sbjct: 64 SNTYDDLAGADVVIVTAGFTKAPGKSDKEWNRDDLLPLNNKIMIEIGGHIKKNCPNAFII 123
Query: 141 ISTNPINYLIPFASTVMYKYGCYNPSKMFGITHI-DTSRSRSFVAKALKINAQEIQVPVI 199
+ TNP++ ++ +++++ +K+ G+ + DTSR + ++++ L + +++ ++
Sbjct: 124 VVTNPVDVMVQ----LLHQHSGVPKNKIIGLGGVLDTSRLKYYISQKLNVCPRDVNAHIV 179
Query: 200 GGHSDKTII 208
G H +K ++
Sbjct: 180 GAHGNKMVL 188
>UniRef50_A0BHM8 Cluster: Malate dehydrogenase; n=3; Paramecium
tetraurelia|Rep: Malate dehydrogenase - Paramecium
tetraurelia
Length = 360
Score = 45.2 bits (102), Expect = 0.003
Identities = 57/276 (20%), Positives = 113/276 (40%), Gaps = 20/276 (7%)
Query: 63 IKGTELELSNLPGGPSVSAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPL 122
+ G +E+ + P V + N N +MV PR PG R +L N +
Sbjct: 86 LNGVVMEIQDC-AFPLVQGIVATDNQSVGFKDVNYALMVGAKPRGPGMERGDLLKDNGKI 144
Query: 123 IQRLCKAIAAQ-NQEAFVAISTNPINYLIPFASTVMYKYGCYNPSKMF-GITHIDTSRSR 180
K I +++ V + NP N + + P + F +T +D +R++
Sbjct: 145 FTETGKYINDHASRDIKVVVVGNPCNTNCLILANQIKDI----PKENFTAMTRLDHNRAQ 200
Query: 181 SFVAKALKINAQEIQVPVIGGHSDKTIIPLFSNLTPRNYRIEPCQ---ADMLTRLVRKAG 237
+A L ++ +I+ I G+ T++P +T +N++ Q V++ G
Sbjct: 201 HQLADKLGVHTSDIRKIAIFGNHSPTMVPYIDQMTAKNHKATVDQQWVTQTFIPTVQQRG 260
Query: 238 TEVVMHKHGAESSTLAMAWSINEFIDIILDAILGYRVVVNCYTANSNFGTK---FFAGPT 294
E++ + + +++ A ++N + G + ++ ++G F+ P
Sbjct: 261 AEIIKARKLSSAASAGNA-AMNHITTWVNGTAEGDYTSM-AIPSDGSYGVPKGLIFSFPV 318
Query: 295 SV--GPHGIIQACCHFPMSEFESYLLNRCIPILSRE 328
+V G + I+Q P+S F LL++ I L E
Sbjct: 319 TVKNGKYSIVQG---LPISPFYQGLLDKTIKELVDE 351
>UniRef50_Q185V1 Cluster: L-lactate dehydrogenase; n=3;
Clostridium|Rep: L-lactate dehydrogenase - Clostridium
difficile (strain 630)
Length = 322
Score = 44.8 bits (101), Expect = 0.003
Identities = 42/189 (22%), Positives = 83/189 (43%), Gaps = 11/189 (5%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYD-DDDRIKGTELELSNLPGGPSVSAFIGD 85
++S++G+ +GS+ L +L + D D+ + K L+L++ I
Sbjct: 7 KISIVGSGH-VGSHCGFSLITQGVCDELFMIDIDESKSKAQALDLADAVSYLPHKVHIEK 65
Query: 86 TNLEQAIHSSNLVVMV---SRMP-RKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAI 141
S +V+ V S P R+ TR +L +I+ + K I + +
Sbjct: 66 GTFSDCKDSDIVVISVADSSEGPLRRQNTTRLDLLRPTIGMIKSIVKPIVDSGFDGIFVV 125
Query: 142 STNPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIG 200
+NP++ + + + K G + +K+ G T +D++R R +++ I Q IQ +G
Sbjct: 126 ISNPVDVVTNY---IWEKSG-FPKNKVIGTGTALDSTRLRRILSEETGIAQQSIQAYSMG 181
Query: 201 GHSDKTIIP 209
H D ++P
Sbjct: 182 EHGDSQMVP 190
>UniRef50_Q9GSY3 Cluster: Malate dehydrogenase; n=1; Hypotrichomonas
acosta|Rep: Malate dehydrogenase - Hypotrichomonas
acosta
Length = 318
Score = 44.4 bits (100), Expect = 0.004
Identities = 37/147 (25%), Positives = 65/147 (44%), Gaps = 5/147 (3%)
Query: 64 KGTELELSNLPGGPSVSAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLI 123
+G LEL + + D LE+A ++ +V+ +P KPG R +L N P+
Sbjct: 31 EGLALELEDCAFQNLEKTIVTD-KLEEACKDIDIAFLVASVPLKPGEHRVNLLTKNTPIF 89
Query: 124 QRLCKAIAAQNQEAFVAIST-NPINYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSF 182
+ + +A++ + A+ NP+N A K N S M + H +RS S
Sbjct: 90 KAIGEALSEYAKPTVRALVVGNPVNSNCLVAMLNAPKLSAENFSCMCTLDH---NRSVSR 146
Query: 183 VAKALKINAQEIQVPVIGGHSDKTIIP 209
+A LK+ + + G+ +T +P
Sbjct: 147 IASHLKVPIDHVYHVAVWGNHAETQVP 173
>UniRef50_P61973 Cluster: Malate dehydrogenase; n=43; Bacteria|Rep:
Malate dehydrogenase - Bdellovibrio bacteriovorus
Length = 335
Score = 44.4 bits (100), Expect = 0.004
Identities = 54/194 (27%), Positives = 82/194 (42%), Gaps = 15/194 (7%)
Query: 23 KRNVQVSVIGAASDIGSYVSLF-------LKRNSKVSKLHLYDDDDR----IKGTELELS 71
K V+V+V GAA IG Y LF L + V L D++ +KG +EL
Sbjct: 2 KAPVRVAVTGAAGQIG-YALLFRIASGAMLGADQPVILQLLEIPDEKAQKALKGVMMELE 60
Query: 72 NLPGGPSVSAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIA 131
+ P + + I + A +++ ++V PR PG R+ +L AN + +AI
Sbjct: 61 DC-AFPLLHSMIATGDPAVAFKDADVALLVGARPRGPGMERKDLLTANGQIFTVQGEAIG 119
Query: 132 A-QNQEAFVAISTNPINYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVA-KALKI 189
N V + NP N A K+G + +D +R+ S +A K K
Sbjct: 120 KYANPNVKVLVVGNPANTNAYIAMKSAMKHGRVKAKNFTAMLRLDHNRALSQLATKTGKP 179
Query: 190 NAQEIQVPVIGGHS 203
A +V V G HS
Sbjct: 180 VASFKKVAVWGNHS 193
>UniRef50_A3JXA9 Cluster: L-lactate dehydrogenase; n=1; Sagittula
stellata E-37|Rep: L-lactate dehydrogenase - Sagittula
stellata E-37
Length = 300
Score = 44.0 bits (99), Expect = 0.006
Identities = 25/118 (21%), Positives = 59/118 (50%), Gaps = 5/118 (4%)
Query: 92 IHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPINYLIP 151
+ +++V++ + +KPG +R ++L NA + + + + +A + I++NP++ +
Sbjct: 56 LSGADVVILACGVSQKPGESRLELLSRNAEVFRAVVGDVTRAAPDAILLIASNPVDIM-- 113
Query: 152 FASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHSDKTII 208
+ V ++ G T +DT+R R + + L I + + V+G H D ++
Sbjct: 114 --THVTQALSGLPAGRVIGSGTILDTARFRWLLGRHLNIAPRSVHAYVLGEHGDTEVL 169
>UniRef50_Q9EVR0 Cluster: L-lactate dehydrogenase; n=1; Selenomonas
ruminantium|Rep: L-lactate dehydrogenase - Selenomonas
ruminantium
Length = 318
Score = 44.0 bits (99), Expect = 0.006
Identities = 43/189 (22%), Positives = 92/189 (48%), Gaps = 15/189 (7%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYD-DDDRIKGTELELSNLPG---GPSVSAF 82
++ VIGA S++GS V+ + +++ L D ++D+ G + S+ ++
Sbjct: 6 KIVVIGA-SNVGSAVANKIADFQLATEVVLIDLNEDKAWGEAKDSSHATSCIYSTNIKFH 64
Query: 83 IGDTNLEQAIHSSNLVVMVSRMPRKPGNT--REQMLGANAPLIQRLCKAIAAQNQEAFVA 140
+GD + +N++V+ + +PG T R ++ G NA ++ + I + +EA +
Sbjct: 65 LGDY---EDCKDANIIVITAGPSIRPGETPDRLKLAGTNAKIMSSVMGEIVKRTKEAMII 121
Query: 141 ISTNPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVI 199
+ TNP++ A+ V+ Y + + G T ++T R R +A +++ + I V+
Sbjct: 122 MITNPLD----VATYVVSTQFDYPRNLILGTGTMLETYRFRRILADKYQVDPKNINGYVL 177
Query: 200 GGHSDKTII 208
G H + +
Sbjct: 178 GEHGNAAFV 186
>UniRef50_A7DSJ4 Cluster: Lactate/malate dehydrogenase; n=1;
Candidatus Nitrosopumilus maritimus SCM1|Rep:
Lactate/malate dehydrogenase - Candidatus Nitrosopumilus
maritimus SCM1
Length = 303
Score = 43.6 bits (98), Expect = 0.008
Identities = 36/189 (19%), Positives = 85/189 (44%), Gaps = 8/189 (4%)
Query: 28 VSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELSNLPGGPSVSAFIGDTN 87
+S++G +G+ ++ N L + ++ G L++++ S + G +
Sbjct: 5 ISIVGTGR-VGASIAFLCVSNGLDDVLLVNTTKEKAIGESLDVASAIPANSKFSIRGTDD 63
Query: 88 LEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPIN 147
+ I S +V+++ R + + +I+ + K I A V + +NP++
Sbjct: 64 YSELIGSD--IVIIAASVGIYTKHRAENIDHQVAMIKNIAKKIKKYCPSAIVLLVSNPLD 121
Query: 148 YLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHSDKT 206
L F K ++ K+ GI + +DTSR R ++++ L + + ++ G +
Sbjct: 122 VLTYF----FQKTTGFSRFKVIGIASSLDTSRFRYYISETLSVPQSSVSNALVLGEHGDS 177
Query: 207 IIPLFSNLT 215
++P+FS ++
Sbjct: 178 MVPIFSGVS 186
>UniRef50_Q8ELF0 Cluster: L-lactate dehydrogenase; n=5;
Bacillaceae|Rep: L-lactate dehydrogenase -
Oceanobacillus iheyensis
Length = 321
Score = 43.6 bits (98), Expect = 0.008
Identities = 42/193 (21%), Positives = 89/193 (46%), Gaps = 13/193 (6%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYD-DDDRIKGTELELSNLPG-GPSVS-AFI 83
+V +IG S +G + L +L + D D D+ G ++L++ PS++ ++
Sbjct: 10 RVVLIGGGS-VGVSYAFALMNQGVTEELAIIDLDADKALGDVMDLNHGKAFAPSLTNVWL 68
Query: 84 GDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAIST 143
G+ +++V + + ++ G TR ++ N + + + + I+T
Sbjct: 69 GEYG---DCKDADIVCICAGANQQSGETRLDLVEKNMKIFKEIVTDVMNSGFNGIFLIAT 125
Query: 144 NPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGH 202
NP++ L + + + P ++ G T +DT+R R + + ++ + I +IG H
Sbjct: 126 NPVDIL----TQAVISFSGLPPHRVIGSGTTLDTARLRYELGEYFHLSPKNIHAYIIGEH 181
Query: 203 SDKTIIPLFSNLT 215
D T +PL+S T
Sbjct: 182 GD-TELPLWSTAT 193
>UniRef50_P07864 Cluster: L-lactate dehydrogenase C chain; n=371;
Eukaryota|Rep: L-lactate dehydrogenase C chain - Homo
sapiens (Human)
Length = 332
Score = 43.6 bits (98), Expect = 0.008
Identities = 35/190 (18%), Positives = 93/190 (48%), Gaps = 9/190 (4%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDD-DRIKGTELELSNLPGGPSVSAFIGD 85
+++++G + +G ++ + +L L D D++KG ++L + S S
Sbjct: 22 KITIVGTGA-VGMACAISILLKDLADELALVDVALDKLKGEMMDLQHGSLFFSTSKITSG 80
Query: 86 TNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNP 145
+ + +S +V++ + ++ G TR ++ N +++ + AI + + + + +NP
Sbjct: 81 KDYSVSANS-RIVIVTAGARQQEGETRLALVQRNVAIMKSIIPAIVHYSPDCKILVVSNP 139
Query: 146 INYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHSD 204
++ L + +++K +++ G ++D++R R + + L ++ +IG H D
Sbjct: 140 VDIL----TYIVWKISGLPVTRVIGSGCNLDSARFRYLIGEKLGVHPTSCHGWIIGEHGD 195
Query: 205 KTIIPLFSNL 214
+ +PL+S +
Sbjct: 196 SS-VPLWSGV 204
>UniRef50_A5IYS9 Cluster: L-lactate dehydrogenase; n=2;
Mycoplasma|Rep: L-lactate dehydrogenase - Mycoplasma
agalactiae
Length = 323
Score = 43.2 bits (97), Expect = 0.010
Identities = 38/166 (22%), Positives = 73/166 (43%), Gaps = 12/166 (7%)
Query: 43 LFLKRNSKVSKLHLYDDDDRIKGTELELSNLPGGPSVSAFIGDTNLEQAIHSSNLVVMVS 102
+ + +N ++++ H +D +D + S +P S F T LE + + +V+ S
Sbjct: 30 VLVDKNVQIAEAHAHDFEDMV-------SLMPRNGST--FRPGTLLEDSKDADVVVITAS 80
Query: 103 RMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPINYLIPFASTVMYKYGC 162
K + R + GANA L+Q K + A + V ++ NP + + A+ V Y
Sbjct: 81 IPADKTFSDRMALAGANAKLMQSFAKDLDAAGFKGIVVVAANPCDVM---AAAVHYGSKI 137
Query: 163 YNPSKMFGITHIDTSRSRSFVAKALKINAQEIQVPVIGGHSDKTII 208
+ T+++T R + +A + I+ V+G H +I
Sbjct: 138 PANRVISAGTNLETGRLKKMLAAKFNTSPDAIRASVLGEHGATAMI 183
>UniRef50_Q6JH30 Cluster: Lactate dehydrogenase; n=3; Plasmodium
(Plasmodium)|Rep: Lactate dehydrogenase - Plasmodium
vivax
Length = 299
Score = 43.2 bits (97), Expect = 0.010
Identities = 23/129 (17%), Positives = 67/129 (51%), Gaps = 10/129 (7%)
Query: 86 TNLEQAIHSSNLVVMVSRMPRKPGNT-----REQMLGANAPLIQRLCKAIAAQNQEAFVA 140
+N + +++V++ + + PG + R+ +L N ++ + I AF+
Sbjct: 57 SNSYDDLKGADVVIVTAGFTKAPGKSDKEWNRDDLLPLNNKIMIEIGGHIKNLCPNAFII 116
Query: 141 ISTNPINYLIPFASTVMYKYGCYNPSKMFGITHI-DTSRSRSFVAKALKINAQEIQVPVI 199
+ TNP++ ++ +++++ +K+ G+ + DTSR + ++++ L + +++ ++
Sbjct: 117 VVTNPVDVMVQ----LLFEHSGVPKNKIIGLGGVLDTSRLKYYISQKLNVCPRDVNALIV 172
Query: 200 GGHSDKTII 208
G H +K ++
Sbjct: 173 GAHGNKMVL 181
>UniRef50_Q6NPB9 Cluster: AT22132p; n=2; Drosophila
melanogaster|Rep: AT22132p - Drosophila melanogaster
(Fruit fly)
Length = 361
Score = 42.7 bits (96), Expect = 0.013
Identities = 47/230 (20%), Positives = 100/230 (43%), Gaps = 22/230 (9%)
Query: 1 MAQKIFCCLFATQLKKNTLILQKRNVQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDD 60
M+ K FA ++ + R ++SV+GA +G+ +S L + L + D +
Sbjct: 24 MSTKSVKSCFAKSMRPMKEFKRPRISKISVVGAGQ-VGTAISAMLLLRNLTKNLVILDIN 82
Query: 61 DRI-KGTELELSNLPGGPSVSAFIGDTNLEQAIHSSNL----VVMVSRMPRKPGNTREQM 115
+ K L+ + SAF+ D + S+N VV+++ R G R ++
Sbjct: 83 YELAKAEALDFQH------ASAFLSDARVVPCGDSTNSKDSDVVIITAGARPSGKDRSRL 136
Query: 116 --LGANAPLIQRLCKAIAAQNQEAFVAISTNPINYLIPFASTV--MYKYGCYNPSKMFGI 171
+ ++++ + + A I +NP + + + + K+ C+
Sbjct: 137 AAMQKTVEILKKAVPKLVELSPNATFIIISNPADVMTYAVQRITNLPKHRCFTTG----- 191
Query: 172 THIDTSRSRSFVAKALKINAQEIQVPVIGGHSDKTIIPLFSNLTPRNYRI 221
H+DT R R+ +A L++ ++ VIG H + +P++S+++ R+
Sbjct: 192 CHLDTVRFRNLIANRLRLPPSQVHGYVIGEHG-ASAVPVWSSVSIAGIRL 240
>UniRef50_Q23CW4 Cluster: Malate dehydrogenase, cytoplasmic,
putative; n=3; Oligohymenophorea|Rep: Malate
dehydrogenase, cytoplasmic, putative - Tetrahymena
thermophila SB210
Length = 365
Score = 42.7 bits (96), Expect = 0.013
Identities = 51/218 (23%), Positives = 92/218 (42%), Gaps = 16/218 (7%)
Query: 15 KKNTLILQKRN--VQVSVIGAASDIG-SYVSLFLKRN---SKVSKLHLYD---DDDRIKG 65
K T + K N + V V GAA IG +++ L L K L L D + ++G
Sbjct: 33 KSKTTVYSKENDEINVCVTGAAGQIGYAFLPLLLTGQCFGDKKINLRLLDVPQAESILQG 92
Query: 66 TELELSNLPGGPSVSAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQR 125
ELEL + P + + +N ++ V + PRKPG R+ +L N + ++
Sbjct: 93 VELELQD-GAYPLLKSIKTGSNESILFQDVDVAVFIGGFPRKPGMERKDLLTINGNIFKK 151
Query: 126 LCKAI-AAQNQEAFVAISTNPINYLIPFASTVMYKYGCYNPSKMF-GITHIDTSRSRSFV 183
+A+ + + NP N ++ + P + F +T +D +R+ S +
Sbjct: 152 QGQALDTVAKKTCKSLVVANPAN----TNCLILAETAKSIPKQNFSALTRLDHNRAISQI 207
Query: 184 AKALKINAQEIQVPVIGGHSDKTIIPLFSNLTPRNYRI 221
A + +++ +I G+ T P ++ T RI
Sbjct: 208 ALKAGCSITDVKNVIIWGNHSTTQYPDVNHGTVLGKRI 245
>UniRef50_Q4JY42 Cluster: L-lactate dehydrogenase; n=1;
Corynebacterium jeikeium K411|Rep: L-lactate
dehydrogenase - Corynebacterium jeikeium (strain K411)
Length = 326
Score = 42.7 bits (96), Expect = 0.013
Identities = 27/117 (23%), Positives = 56/117 (47%), Gaps = 6/117 (5%)
Query: 97 LVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPINYLIPFASTV 156
+V + + +KPG TR ++ N + + + + + +++NP++ L S
Sbjct: 86 MVCICAGAAQKPGETRLDLVAKNTAIFKTIVGDVMSHGFNGIFLVASNPVDIL----SYA 141
Query: 157 MYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHSDKTIIPLFS 212
+K+ + S++ G T +DT+R R + + + + VIG H D T +P+ S
Sbjct: 142 TWKFSGMDSSRVIGSGTILDTARFRYALGRYFDLAPTSVHAYVIGEHGD-TELPVLS 197
>UniRef50_Q0UX88 Cluster: L-lactate dehydrogenase; n=2;
Phaeosphaeria nodorum|Rep: L-lactate dehydrogenase -
Phaeosphaeria nodorum (Septoria nodorum)
Length = 326
Score = 41.5 bits (93), Expect = 0.031
Identities = 46/226 (20%), Positives = 100/226 (44%), Gaps = 11/226 (4%)
Query: 28 VSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELELSNLPGGPSVSAFIGDTN 87
++VIG D+G+ ++ L S +++ L D + + ++ +L S S +
Sbjct: 10 IAVIGCG-DVGATLAYTLILQSICTEVLLVDPKTSL--LDGQVRDLSDATSRSTKVRSGT 66
Query: 88 LEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPIN 147
++A +++VV+ + +K G +R +L N ++ + ++ + + + NP++
Sbjct: 67 HQEA-GQADIVVITAGAKQKTGESRLSLLTRNLNILSSIFDSMKPISAHTVLLLVANPVD 125
Query: 148 YLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEIQVPVIGGHSDKTI 207
L+ FA + G + T +D++R R +A ++ I V+G H D
Sbjct: 126 ILVYFARMMS---GLPENQVLGTGTSLDSARLRGVLAGKAGVSPSSIDAYVLGEHGDSQF 182
Query: 208 IPLFSNLTPRNYRIEPCQADMLTRLVRKAGTEVVMHKHGAESSTLA 253
+ +S+ + + D LT ++ EV M GA + +A
Sbjct: 183 V-AWSSASIGTTPLRLALGDELTDEFKE---EVAMKTRGAAGAIIA 224
>UniRef50_A1W9K7 Cluster: Malate dehydrogenase; n=95; cellular
organisms|Rep: Malate dehydrogenase - Acidovorax sp.
(strain JS42)
Length = 328
Score = 41.5 bits (93), Expect = 0.031
Identities = 52/197 (26%), Positives = 89/197 (45%), Gaps = 20/197 (10%)
Query: 21 LQKRNVQVSVIGAASDIGSYVSLF-------LKRNSKV--SKLHLYDD--DDRIKGTELE 69
+ K+ V+V+V GAA IG Y LF L ++ V L + D+ + +KG +E
Sbjct: 1 MSKKPVRVAVTGAAGQIG-YALLFRIASGEMLGKDQPVILQLLEIPDEKAQNALKGVIME 59
Query: 70 LSNLPGGPSVSAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKA 129
L + P ++ ++ A ++ ++V PR PG R +L ANA + KA
Sbjct: 60 LEDC-AFPLLAGIEAHSDPMTAFKDTDYALLVGARPRGPGMERADLLAANAQIFTAQGKA 118
Query: 130 I-AAQNQEAFVAISTNPINYLIPFASTVMYKYGCYNPSKMF-GITHIDTSRSRSFVAKAL 187
+ A ++ V + NP N + + K P+K F + +D +R+ S +A
Sbjct: 119 LNAVASRNVKVLVVGNPAN----TNAYIAMKSAPDLPAKNFTAMLRLDHNRAASQLAAKG 174
Query: 188 KINAQEI-QVPVIGGHS 203
+I ++ V G HS
Sbjct: 175 GFKVGDIKKLTVWGNHS 191
>UniRef50_O52354 Cluster: L-lactate dehydrogenase; n=1; Mycoplasma
gallisepticum|Rep: L-lactate dehydrogenase - Mycoplasma
gallisepticum
Length = 323
Score = 41.5 bits (93), Expect = 0.031
Identities = 43/199 (21%), Positives = 80/199 (40%), Gaps = 18/199 (9%)
Query: 112 REQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPINYLIPFASTVMYKYGCYNPSKMFGI 171
R Q++ AN ++ + + + I TNP + + + V K ++P K+
Sbjct: 94 RLQLMTANVKILNEIALELKRVGFKGLSIIPTNPCDVM----AGVYQKVTGFDPHKIIST 149
Query: 172 -THIDTSRSRSFVAKALKINAQEIQVPVIGGHSDKTIIPL---------FSNLTPRNYRI 221
++T R+R +++AL +N+ ++ V+G H I+P L
Sbjct: 150 GCQLETMRTRKMISEALGVNSDSVEGFVVGEHGSGAIVPWSVFRVGNVPMKQLIAEGKIK 209
Query: 222 EPCQADMLTRLVRKAGTEVVMHKHGAESSTLAMAWSINEFIDIILDAILGYRVVVNCYTA 281
E D+ +R+V++A E++ K I L+ +LG V ++
Sbjct: 210 EEYVKDIFSRVVKEA-FEIIKFKKATYFGIAESMSLITRAYIYNLNTVLGVGVQLDDKYV 268
Query: 282 NSNFGTKFFAGPTSVGPHG 300
S +F P VG HG
Sbjct: 269 ASGI---YFTVPAVVGKHG 284
>UniRef50_A3ZZ88 Cluster: L-lactate/malate dehydrogenase; n=1;
Blastopirellula marina DSM 3645|Rep: L-lactate/malate
dehydrogenase - Blastopirellula marina DSM 3645
Length = 308
Score = 40.7 bits (91), Expect = 0.054
Identities = 28/108 (25%), Positives = 58/108 (53%), Gaps = 8/108 (7%)
Query: 130 IAAQNQEAFVAISTNPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALK 188
+AA + +A + TNP++ + FA + + ++FG+ T +DT+R R +++
Sbjct: 105 LAAASPQAICVMVTNPVDVMTWFA----LQLSGFPQERVFGVGTLLDTARLRRLLSERWS 160
Query: 189 INAQEIQVPVIGGHSDKTIIPLFSNLTPRNYRIEPCQADMLTRLVRKA 236
++A +++ VIG H + + FS+ + ++P +D L L R+A
Sbjct: 161 VHASDVRAYVIGEHGEDQVAS-FSSASLGGEAMKP--SDDLASLARQA 205
>UniRef50_Q4J9W2 Cluster: Putative uncharacterized protein; n=1;
Sulfolobus acidocaldarius|Rep: Putative uncharacterized
protein - Sulfolobus acidocaldarius
Length = 193
Score = 40.7 bits (91), Expect = 0.054
Identities = 25/80 (31%), Positives = 40/80 (50%), Gaps = 3/80 (3%)
Query: 3 QKIFCCLFATQLKKNTLILQKRNVQVSVIGAASDIGS---YVSLFLKRNSKVSKLHLYDD 59
+ ++ L + K N+L L RN+++ I DIG YV +F+ K + +H+ +
Sbjct: 88 EPVYANLLFRKSKVNSLTLVLRNMKILKISYPHDIGDSLFYVKVFIDYADKFNTVHINSE 147
Query: 60 DDRIKGTELELSNLPGGPSV 79
+D I L NLPG SV
Sbjct: 148 NDAIIFLNLARDNLPGKVSV 167
>UniRef50_A1C5Q5 Cluster: L-lactate dehydrogenase; n=4;
Pezizomycotina|Rep: L-lactate dehydrogenase -
Aspergillus clavatus
Length = 312
Score = 40.3 bits (90), Expect = 0.072
Identities = 38/181 (20%), Positives = 82/181 (45%), Gaps = 13/181 (7%)
Query: 27 QVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIKGTELE----LSNLPGGPSVSAF 82
+++++G +G + L S +L L D ++ +++ +SN+ GG
Sbjct: 9 RIAIVGVGQ-VGGAAANALILGSVARELLLVDVKIPLRNAQVQELSDVSNMSGGAETRIR 67
Query: 83 IGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAIS 142
G E+A ++VV+ + G T Q + N ++Q++ A+ + + +
Sbjct: 68 AG--TYEEA-GQCDIVVITAGSKYSVGETSVQHMYRNMGIVQKIIPAMRPFRPDTILLVV 124
Query: 143 TNPINYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGG 201
+NP++ L +TV + P+++ G T +++ R R VAK + + + V+G
Sbjct: 125 SNPVDLL----TTVAQQLSGLPPTQVLGSGTLLESVRLRGLVAKTTGVAPDSVDLYVLGV 180
Query: 202 H 202
H
Sbjct: 181 H 181
>UniRef50_Q82R06 Cluster: Putative lactate dehydrogenase; n=1;
Streptomyces avermitilis|Rep: Putative lactate
dehydrogenase - Streptomyces avermitilis
Length = 303
Score = 39.5 bits (88), Expect = 0.13
Identities = 35/118 (29%), Positives = 60/118 (50%), Gaps = 14/118 (11%)
Query: 119 NAPLIQRLCKAIAAQNQEAFVAISTNPINYLIP-FASTVMYKYGCYNPSKMFGI-THIDT 176
NAP+I+ L A + + V + TNP++ + FA T GC +++GI +++D+
Sbjct: 97 NAPVIRAL--ATTLRGYQGTVLVVTNPVDLMTRLFAETS----GC---PRVYGIGSNLDS 147
Query: 177 SRSRSFVAKALKINAQEIQVPVIGGHSDKTIIPLFS---NLTPRNYRIEPCQADMLTR 231
+R R +A L + A + VIG H D ++ S N TP + +A++ TR
Sbjct: 148 ARYRLTLAHLLDVPATTVHGHVIGEHGDGAVVCASSTTVNGTPAAVPLAEVRAELRTR 205
>UniRef50_Q8I8U4 Cluster: Lactate dehydrogenase; n=3;
Eimeriorina|Rep: Lactate dehydrogenase - Eimeria tenella
Length = 331
Score = 39.1 bits (87), Expect = 0.17
Identities = 38/194 (19%), Positives = 92/194 (47%), Gaps = 14/194 (7%)
Query: 24 RNVQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDDDRIK-GTELELSNLPGGPSVSAF 82
R +++++G+ IG + FL ++ + L+D + G L+L +
Sbjct: 8 RRPKIALVGSGM-IGGTMG-FLCSLRELGDVVLFDVVPNMPAGKALDLCHTAAVADNGVR 65
Query: 83 IGDTNLEQAIHSSNLVVMVSRMPRKPGNT-----REQMLGANAPLIQRLCKAIAAQNQEA 137
+ N ++ +++V++ + + + G + R+ +L N +++ + AI A
Sbjct: 66 VQGANSYASLEGADVVIITAGITKAAGKSDQEWSRKDLLPVNVKILREVGAAIKQFCPHA 125
Query: 138 FVAISTNPINYLIPFASTVMYKYGCYNPSKMFGITHI-DTSRSRSFVAKALKINAQEIQV 196
FV TNP++ ++ + + +++ G+ + D++R R +A L ++ +++Q
Sbjct: 126 FVINITNPLDVMV----AALREAAGLPAARVCGMAGVLDSARFRRLLADRLGVSPRDVQA 181
Query: 197 PVIGGHSDKTIIPL 210
V+G H D ++PL
Sbjct: 182 MVLGVHGD-NMVPL 194
>UniRef50_Q9GPV2 Cluster: Cytosolic malate dehydrogenase; n=4;
Trichomonadida|Rep: Cytosolic malate dehydrogenase -
Tetratrichomonas gallinarum
Length = 314
Score = 38.7 bits (86), Expect = 0.22
Identities = 31/150 (20%), Positives = 66/150 (44%), Gaps = 9/150 (6%)
Query: 63 IKGTELELSNLPGGPSVSAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPL 122
++G +EL + P+V+ + +E+A ++ +V PRK G R +L N +
Sbjct: 31 LEGCVMELQDC-AFPNVAGIVWTDKIEEAFKDVDVAFLVGSFPRKDGMDRSDLLAKNGGI 89
Query: 123 IQRLCKAIA-AQNQEAFVAISTNPINYLIPFASTVMYKYGCYNPSK--MFGITHIDTSRS 179
KA++ ++ V + NP N + ++ + N SK +T +D +R
Sbjct: 90 FTVQGKALSDFAKKDVKVLVVGNPAN-----TNCLIAQASAPNLSKKNWCAMTRLDHNRM 144
Query: 180 RSFVAKALKINAQEIQVPVIGGHSDKTIIP 209
+A + +++ ++ G+ T +P
Sbjct: 145 VGALAAKFGVTPEKVHNVIVWGNHSNTQVP 174
>UniRef50_Q8I8I5 Cluster: Malate dehydrogenase; n=2; Eukaryota|Rep:
Malate dehydrogenase - Mastigamoeba balamuthi
(Phreatamoeba balamuthi)
Length = 382
Score = 37.9 bits (84), Expect = 0.38
Identities = 28/121 (23%), Positives = 55/121 (45%), Gaps = 4/121 (3%)
Query: 90 QAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIA-AQNQEAFVAISTNPINY 148
+A +++VV+V PR G R +L NA + + KA++ + + V + NP N
Sbjct: 120 EAFAGAHVVVLVGSSPRAAGQLRRDLLAQNAAIFKAQGKAVSDYADPDVRVLVVANPANT 179
Query: 149 LIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEIQVPVIGGHSDKTII 208
S + S M T +D +RS++ +A+ + + + + ++ G+ T
Sbjct: 180 NCLVFSRCAPNIPRTHVSCM---TRLDHNRSKAQIAERVGVETRNVHNAIVWGNHSGTQY 236
Query: 209 P 209
P
Sbjct: 237 P 237
>UniRef50_Q9Z6N1 Cluster: Malate dehydrogenase; n=8;
Chlamydiaceae|Rep: Malate dehydrogenase - Chlamydia
pneumoniae (Chlamydophila pneumoniae)
Length = 328
Score = 37.9 bits (84), Expect = 0.38
Identities = 45/196 (22%), Positives = 80/196 (40%), Gaps = 16/196 (8%)
Query: 23 KRNVQVSVIGAASDIGSYVSLFLKRNSKVS------KLHLYD---DDDRIKGTELELSNL 73
K V+V+V G I +Y LF + V L +YD + + G +EL +
Sbjct: 4 KEVVRVAVTGGKGQI-AYNFLFALAHGDVFGVDRGVDLRIYDVPGTERALSGVRMELDD- 61
Query: 74 PGGPSVSAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAI-AA 132
P + T+L A + ++ +PR PG R +L N + A+ A
Sbjct: 62 GAYPLLHRLRVTTSLNDAFDGIDAAFLIGAVPRGPGMERGDLLKQNGQIFSLQGAALNTA 121
Query: 133 QNQEAFVAISTNPINYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQ 192
++A + + NP+N A M + + +D +R S +A ++ +
Sbjct: 122 AKRDAKIFVVGNPVNTNCWIA---MKHAPRLHRKNFHAMLRLDQNRMHSMLAHRAEVPLE 178
Query: 193 EI-QVPVIGGHSDKTI 207
E+ +V + G HS K +
Sbjct: 179 EVSRVVIWGNHSAKQV 194
>UniRef50_Q9UAV5 Cluster: Malate dehydrogenase; n=15; Eukaryota|Rep:
Malate dehydrogenase - Caenorhabditis elegans
Length = 336
Score = 37.5 bits (83), Expect = 0.50
Identities = 34/154 (22%), Positives = 66/154 (42%), Gaps = 4/154 (2%)
Query: 63 IKGTELELSNLPGGPSVSAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPL 122
++G EL + P++ + + T+ + A + +V MPR+ G R+ +L AN +
Sbjct: 50 LEGVVFELQDC-ALPTLFSVVAVTDEKSAFTGIDYAFLVGAMPRREGMERKDLLAANVKI 108
Query: 123 IQRLCKAIAAQNQEAF-VAISTNPINYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRS 181
+ KA+A + V + NP N A+ Y G +T +D +R+ +
Sbjct: 109 FKSQGKALAEYAKPTTKVIVVGNPANTNAFIAA--KYAAGKIPAKNFSAMTRLDHNRALA 166
Query: 182 FVAKALKINAQEIQVPVIGGHSDKTIIPLFSNLT 215
+A ++ +I G+ T P ++ T
Sbjct: 167 QLALKTGTTIGNVKNVIIWGNHSGTQFPDVTHAT 200
>UniRef50_Q03ZZ4 Cluster: Enzyme with possible activities of L-2-
hydroxyisocaproate/malate/lactate dehydrogenase; n=3;
Lactobacillales|Rep: Enzyme with possible activities of
L-2- hydroxyisocaproate/malate/lactate dehydrogenase -
Leuconostoc mesenteroides subsp. mesenteroides (strain
ATCC 8293 /NCDO 523)
Length = 304
Score = 37.1 bits (82), Expect = 0.67
Identities = 26/100 (26%), Positives = 50/100 (50%), Gaps = 7/100 (7%)
Query: 107 KPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPINYLIPFASTVMYKYGCYNP- 165
KPG R L AN P +Q++ + + + +NP++ + T +Y+ P
Sbjct: 84 KPGGDRFTELKANTPEVQQVGSDLKQAGFNGVLIVISNPVDVI-----TGIYQKATGLPA 138
Query: 166 SKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHSD 204
+++FG T++DT+R + + L I+ + I ++G H D
Sbjct: 139 NQVFGTGTYLDTARLKRALGDTLAIDPRGISGYMLGEHGD 178
>UniRef50_A4BB89 Cluster: Lactate dehydrogenase; n=2;
Gammaproteobacteria|Rep: Lactate dehydrogenase -
Reinekea sp. MED297
Length = 319
Score = 36.7 bits (81), Expect = 0.88
Identities = 63/318 (19%), Positives = 127/318 (39%), Gaps = 22/318 (6%)
Query: 26 VQVSVIGAASDIGSYVSLFLKRNSKVSKLHLYDDD-DRIKGTELEL---SNLPGGPSVSA 81
+++ VIGA + +G V + S+L L D + +G ++ ++L ++
Sbjct: 1 MKIGVIGAGA-VGVGVCHYTLAFGSCSELVLIDQQIGKAEGEMMDFGHANSLTFSKNIRL 59
Query: 82 FIGDTNLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAI 141
GD + +++VV+ + K G TR+ + N+ + + + I A + +
Sbjct: 60 RAGDDY--SLLTDADIVVITAGAQIKEGQTRDDLAEINSRITVDIAQKIETVAPNAILLV 117
Query: 142 STNPINYLIPFASTVMYKYGCYNPSKMFGITHIDTSRSRSFVAKALKINAQEIQVPVIGG 201
TNP + F + G + IDT+R V++ + ++ + + ++G
Sbjct: 118 VTNPCDIATYF---ITQNTGFPADRVISAGCIIDTARLMKLVSEKVDVDPKNVSGYILGE 174
Query: 202 HSDKTIIP---LFSNLTPRNY-----RIEPCQADMLTRLVRKAGTEVVMHKHGAESSTLA 253
H +P + P +Y + L V++AG E+ KH A
Sbjct: 175 HGSHCFMPWGLVGVAGQPIDYYCQHNGFDAIDPQTLLEEVKQAGFEIFKRKHNTTHGIAA 234
Query: 254 MAWSINEFIDIILDAILGYRVVVNCYTANSNFGTKFFAGPTSVGPHGIIQACCHFPMSEF 313
+ + + I I +IL +++ + S+ + PT V G + H P SE
Sbjct: 235 SVFRMIQAITIDEYSILPVGTLLSGHYGLSDV---VLSLPTIVNARGAHKVLEH-PFSET 290
Query: 314 ESYLLNRCIPILSREVLE 331
E+ L+ L + + E
Sbjct: 291 ETRELHDIAAALQKLIRE 308
>UniRef50_Q22N17 Cluster: Putative uncharacterized protein; n=1;
Tetrahymena thermophila SB210|Rep: Putative
uncharacterized protein - Tetrahymena thermophila SB210
Length = 3435
Score = 35.1 bits (77), Expect = 2.7
Identities = 15/53 (28%), Positives = 31/53 (58%), Gaps = 1/53 (1%)
Query: 59 DDDRIKGTELELSNLPGGPSVSAFIGDTNLEQAIHSSNLVVMVSRMPRKPGNT 111
+ + I+G +E +L G P + F+G N+ + S N ++++S+ P+K N+
Sbjct: 1400 NQEAIQGASIEAKSLKGSPLCTRFVG-KNILATVDSQNNLILMSQQPQKNQNS 1451
>UniRef50_Q0P989 Cluster: L-lactate dehydrogenase; n=10;
Campylobacter|Rep: L-lactate dehydrogenase -
Campylobacter jejuni
Length = 308
Score = 34.7 bits (76), Expect = 3.6
Identities = 31/125 (24%), Positives = 58/125 (46%), Gaps = 5/125 (4%)
Query: 87 NLEQAIHSSNLVVMVSRMPRKPGNTREQMLGANAPLIQRLCKAIAAQNQEAFVAISTNPI 146
NLE +++ + K +R L N ++ + + N + ++TNP
Sbjct: 64 NLENLASCDIIILAFRKESLKELPSRLVELKNNILELKDIVLTLKNANFKGKYIVATNP- 122
Query: 147 NYLIPFASTVMYKYGCYNPSKMFGI-THIDTSRSRSFVAKALKINAQEIQVPVIGGHSDK 205
N I + + V+ + + +FG T++D+SR + +AK L IN+++I +IG H D
Sbjct: 123 NDTITYYTQVLSQLP---KNHVFGSGTNLDSSRLKKLLAKDLNINSKDIFACMIGEHGDS 179
Query: 206 TIIPL 210
L
Sbjct: 180 QFAAL 184
>UniRef50_Q2U1D9 Cluster: Predicted protein; n=1; Aspergillus
oryzae|Rep: Predicted protein - Aspergillus oryzae
Length = 344
Score = 34.3 bits (75), Expect = 4.7
Identities = 15/30 (50%), Positives = 20/30 (66%)
Query: 243 HKHGAESSTLAMAWSINEFIDIILDAILGY 272
H H +ST++MAW+ FI IIL I+GY
Sbjct: 176 HYHVYPNSTVSMAWNHYRFIRIILQGIIGY 205
>UniRef50_A1ZW20 Cluster: Putative uncharacterized protein; n=1;
Microscilla marina ATCC 23134|Rep: Putative
uncharacterized protein - Microscilla marina ATCC 23134
Length = 291
Score = 33.9 bits (74), Expect = 6.2
Identities = 22/68 (32%), Positives = 36/68 (52%), Gaps = 2/68 (2%)
Query: 41 VSLFLKRNSKVSKLHLYDDDDRIKGTELELSNLPGGPSVSAFIGDTNLEQAIHSSNLVVM 100
+S + K V+K +++ +D R G +L+ NLPG AF N E + +LV +
Sbjct: 185 ISPYSKIKMSVTKQYIHWNDARSTG-QLKKMNLPGTVVGGAFFS-ANYELGTVAYHLVAL 242
Query: 101 VSRMPRKP 108
+R P+KP
Sbjct: 243 YTRQPQKP 250
>UniRef50_P15719 Cluster: Malate dehydrogenase [NADP], chloroplast
precursor; n=62; cellular organisms|Rep: Malate
dehydrogenase [NADP], chloroplast precursor - Zea mays
(Maize)
Length = 432
Score = 33.9 bits (74), Expect = 6.2
Identities = 29/119 (24%), Positives = 53/119 (44%), Gaps = 10/119 (8%)
Query: 99 VMVSRMPRKPGNTREQMLGANAPLIQ---RLCKAIAAQNQEAFVAISTNPINYLIPFAST 155
+++ PR PG R +L N + + A+A++N E V + NP N +
Sbjct: 170 LLIGAKPRGPGMERAALLDINGQIFADQGKALNAVASRNDE--VLVVGNPCN----TNAL 223
Query: 156 VMYKYGCYNPSKMF-GITHIDTSRSRSFVAKALKINAQEIQVPVIGGHSDKTIIPLFSN 213
+ K P+K F +T +D +R++ +A + ++ I G+ T +P F N
Sbjct: 224 ICLKNAPNIPAKNFHALTRLDENRAKCQLALKAGVFYDKVSNVTIWGNHSTTQVPDFLN 282
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.321 0.135 0.397
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 359,105,752
Number of Sequences: 1657284
Number of extensions: 14104376
Number of successful extensions: 31197
Number of sequences better than 10.0: 162
Number of HSP's better than 10.0 without gapping: 90
Number of HSP's successfully gapped in prelim test: 72
Number of HSP's that attempted gapping in prelim test: 30945
Number of HSP's gapped (non-prelim): 171
length of query: 344
length of database: 575,637,011
effective HSP length: 101
effective length of query: 243
effective length of database: 408,251,327
effective search space: 99205072461
effective search space used: 99205072461
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.9 bits)
S2: 73 (33.5 bits)
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