Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001138-TA|BGIBMGA001138-
PA|IPR005135|Endonuclease/exonuclease/phosphatase
(404 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
AL109947-3|CAI23338.1| 423|Homo sapiens sphingomyelin phosphodi... 199 1e-50
BC000038-1|AAH00038.1| 423|Homo sapiens sphingomyelin phosphodi... 199 2e-50
AJ222801-1|CAA10995.1| 423|Homo sapiens neutral sphingomyelinas... 199 2e-50
AL109947-4|CAI23340.1| 77|Homo sapiens sphingomyelin phosphodi... 86 2e-16
AL109947-5|CAI23341.1| 203|Homo sapiens sphingomyelin phosphodi... 47 1e-04
DQ424899-1|ABD83664.1| 638|Homo sapiens sphingomyelin phosphodi... 42 0.004
BC112238-1|AAI12239.1| 655|Homo sapiens sphingomyelin phosphodi... 41 0.007
AJ250460-1|CAB92964.1| 655|Homo sapiens neutral sphingomyelinas... 41 0.007
BC064593-1|AAH64593.1| 385|Homo sapiens DCP2 protein protein. 33 2.4
BC112210-1|AAI12211.1| 474|Homo sapiens PRAME family member 10 ... 31 7.2
BC112208-1|AAI12209.1| 474|Homo sapiens PRAME family member 10 ... 31 7.2
AL049682-1|CAB41254.1| 459|Homo sapiens hypothetical protein pr... 31 7.2
AL022101-3|CAA17876.1| 459|Homo sapiens PRAME family member 10 ... 31 7.2
>AL109947-3|CAI23338.1| 423|Homo sapiens sphingomyelin
phosphodiesterase 2, neutral membrane (neutral
sphingomyelinase) protein.
Length = 423
Score = 199 bits (486), Expect = 1e-50
Identities = 104/270 (38%), Positives = 154/270 (57%), Gaps = 6/270 (2%)
Query: 11 GIPVVSKNKKERYEAISTYLLKSEHNIVCLQEVWSEKDYLYLKENLKNVLPYSYYFYSGV 70
GIP +SK++ +R + +L + ++ L+EVWSE+D+ YL++ L P +++F SG+
Sbjct: 18 GIPYLSKHRADRMRRLGDFLNQESFDLALLEEVWSEQDFQYLRQKLSPTYPAAHHFRSGI 77
Query: 71 LGSGLCVFSKWVIQDVFFHQWPLNGYIHKIHHGDWFGGKGVGLCRIKFGERLINVYCTHL 130
+GSGLCVFSK IQ++ H + LNGY + IHHGDWF GK VGL + ++N Y THL
Sbjct: 78 IGSGLCVFSKHPIQELTQHIYTLNGYPYMIHHGDWFSGKAVGLLVLHLSGMVLNAYVTHL 137
Query: 131 HAEYH-EDDMYLAHRVLQAYSTAEFVKLTSSPADVSILAGDLNTAPGDLSYKIISQLPSL 189
HAEY+ + D+YLAHRV QA+ A+F+ TS ADV +L GDLN P DL ++ + L
Sbjct: 138 HAEYNRQKDIYLAHRVAQAWELAQFIHHTSKKADVVLLCGDLNMHPEDLGCCLLKEWTGL 197
Query: 190 LDPYNMKFEGTNPLIAKASGTSDNLNNSYSDPKQVKAYPEGKRIDHILFHTNHSWEARVV 249
D Y E T G + N Y +++K +P G RID++L+ +
Sbjct: 198 HDAY---LE-TRDFKGSEEGNTMVPKNCYVSQQELKPFPFGVRIDYVLYKAVSGFYISCK 253
Query: 250 NFGNPLPDRVPEQQFSYSDHNAVSLELHLK 279
+F P + SDH A+ L ++
Sbjct: 254 SF-ETTTGFDPHRGTPLSDHEALMATLFVR 282
>BC000038-1|AAH00038.1| 423|Homo sapiens sphingomyelin
phosphodiesterase 2, neutral membrane (neutral
sphingomyelinase) protein.
Length = 423
Score = 199 bits (485), Expect = 2e-50
Identities = 104/270 (38%), Positives = 153/270 (56%), Gaps = 6/270 (2%)
Query: 11 GIPVVSKNKKERYEAISTYLLKSEHNIVCLQEVWSEKDYLYLKENLKNVLPYSYYFYSGV 70
GIP +SK++ +R + +L + ++ L+EVWSE+D+ YL++ L P +++F SG+
Sbjct: 18 GIPYLSKHRADRMRRLGDFLNQESFDLALLEEVWSEQDFQYLRQKLSPTYPAAHHFRSGI 77
Query: 71 LGSGLCVFSKWVIQDVFFHQWPLNGYIHKIHHGDWFGGKGVGLCRIKFGERLINVYCTHL 130
+GSGLCVFSK IQ++ H + LNGY + IHHGDWF GK VGL + ++N Y THL
Sbjct: 78 IGSGLCVFSKHPIQELTQHIYTLNGYPYMIHHGDWFSGKAVGLLVLHLSGMVLNAYVTHL 137
Query: 131 HAEYH-EDDMYLAHRVLQAYSTAEFVKLTSSPADVSILAGDLNTAPGDLSYKIISQLPSL 189
HAEY+ + D+YLAHRV QA+ A+F+ TS ADV +L GDLN P DL ++ + L
Sbjct: 138 HAEYNRQKDIYLAHRVAQAWELAQFIHHTSKKADVVLLCGDLNMHPEDLGCCLLKEWTGL 197
Query: 190 LDPYNMKFEGTNPLIAKASGTSDNLNNSYSDPKQVKAYPEGKRIDHILFHTNHSWEARVV 249
D Y E T G + N Y +++K +P G RID++L+ +
Sbjct: 198 HDAY---LE-TRDFKGSEEGNTMVPKNCYVSQQELKPFPFGVRIDYVLYKAVSGFYISCK 253
Query: 250 NFGNPLPDRVPEQQFSYSDHNAVSLELHLK 279
+F P SDH A+ L ++
Sbjct: 254 SF-ETTTGFDPHSGTPLSDHEALMATLFVR 282
>AJ222801-1|CAA10995.1| 423|Homo sapiens neutral sphingomyelinase
protein.
Length = 423
Score = 199 bits (485), Expect = 2e-50
Identities = 104/270 (38%), Positives = 153/270 (56%), Gaps = 6/270 (2%)
Query: 11 GIPVVSKNKKERYEAISTYLLKSEHNIVCLQEVWSEKDYLYLKENLKNVLPYSYYFYSGV 70
GIP +SK++ +R + +L + ++ L+EVWSE+D+ YL++ L P +++F SG+
Sbjct: 18 GIPYLSKHRADRMRRLGDFLNQESFDLALLEEVWSEQDFQYLRQKLSPTYPAAHHFRSGI 77
Query: 71 LGSGLCVFSKWVIQDVFFHQWPLNGYIHKIHHGDWFGGKGVGLCRIKFGERLINVYCTHL 130
+GSGLCVFSK IQ++ H + LNGY + IHHGDWF GK VGL + ++N Y THL
Sbjct: 78 IGSGLCVFSKHPIQELTQHIYTLNGYPYMIHHGDWFSGKAVGLLVLHLSGMVLNAYVTHL 137
Query: 131 HAEYH-EDDMYLAHRVLQAYSTAEFVKLTSSPADVSILAGDLNTAPGDLSYKIISQLPSL 189
HAEY+ + D+YLAHRV QA+ A+F+ TS ADV +L GDLN P DL ++ + L
Sbjct: 138 HAEYNRQKDIYLAHRVAQAWELAQFIHHTSKKADVVLLCGDLNMHPEDLGCCLLKEWTGL 197
Query: 190 LDPYNMKFEGTNPLIAKASGTSDNLNNSYSDPKQVKAYPEGKRIDHILFHTNHSWEARVV 249
D Y E T G + N Y +++K +P G RID++L+ +
Sbjct: 198 HDAY---LE-TRDFKGSEEGNTMVPKNCYVSQQELKPFPFGVRIDYVLYKAVSGFYISCK 253
Query: 250 NFGNPLPDRVPEQQFSYSDHNAVSLELHLK 279
+F P SDH A+ L ++
Sbjct: 254 SF-ETTTGFDPHSGTPLSDHEALMATLFVR 282
>AL109947-4|CAI23340.1| 77|Homo sapiens sphingomyelin
phosphodiesterase 2, neutral membrane (neutral
sphingomyelinase) protein.
Length = 77
Score = 86.2 bits (204), Expect = 2e-16
Identities = 36/70 (51%), Positives = 49/70 (70%)
Query: 61 PYSYYFYSGVLGSGLCVFSKWVIQDVFFHQWPLNGYIHKIHHGDWFGGKGVGLCRIKFGE 120
P +++F SG++GSGLCVFSK IQ++ H + LNGY + IHHGDWF GK VGL +
Sbjct: 2 PAAHHFRSGIIGSGLCVFSKHPIQELTQHIYTLNGYPYMIHHGDWFSGKAVGLLVLHLSG 61
Query: 121 RLINVYCTHL 130
++N Y TH+
Sbjct: 62 MVLNAYVTHV 71
>AL109947-5|CAI23341.1| 203|Homo sapiens sphingomyelin
phosphodiesterase 2, neutral membrane (neutral
sphingomyelinase) protein.
Length = 203
Score = 46.8 bits (106), Expect = 1e-04
Identities = 35/122 (28%), Positives = 53/122 (43%), Gaps = 5/122 (4%)
Query: 158 TSSPADVSILAGDLNTAPGDLSYKIISQLPSLLDPYNMKFEGTNPLIAKASGTSDNLNNS 217
TS ADV +L GDLN P DL ++ + L D Y E T G + N
Sbjct: 62 TSKKADVVLLCGDLNMHPEDLGCCLLKEWTGLHDAY---LE-TRDFKGSEEGNTMVPKNC 117
Query: 218 YSDPKQVKAYPEGKRIDHILFHTNHSWEARVVNFGNPLPDRVPEQQFSYSDHNAVSLELH 277
Y +++K +P G RID++L+ + +F P + SDH A+ L
Sbjct: 118 YVSQQELKPFPFGVRIDYVLYKAVSGFYISCKSF-ETTTGFDPHRGTPLSDHEALMATLF 176
Query: 278 LK 279
++
Sbjct: 177 VR 178
>DQ424899-1|ABD83664.1| 638|Homo sapiens sphingomyelin
phosphodiesterase 3 protein.
Length = 638
Score = 41.9 bits (94), Expect = 0.004
Identities = 71/260 (27%), Positives = 103/260 (39%), Gaps = 51/260 (19%)
Query: 36 NIVCLQEVWSEKDYLYLKENLKNVLPYSYY---FYS-------GVLGSGLCVFSKWVIQD 85
+ +CLQEV+ ++ LKE L Y Y Y L SGL S++ I D
Sbjct: 358 DFLCLQEVFDKRAATKLKEQLHGYFEYILYDVGVYGCQGCCSFKCLNSGLLFASRYPIMD 417
Query: 86 VFFHQWPLNGYIHKIHHGDWFGGKGVGLCRIKFG-----ERLIN-VYCTHLHAEYHEDDM 139
V +H +P +K + D KG +++ G +R++ + CTHLHA + +
Sbjct: 418 VAYHCYP-----NKC-NDDALASKGALFLKVQVGSTPQDQRIVGYIACTHLHAPQEDSAI 471
Query: 140 YLAHRVLQAYSTAEFVKLTS-----SPADV---SILAGDLNTAPGDLSYKIISQL----- 186
L A+F K TS +P ++ ++ GD N K+ Q
Sbjct: 472 RCGQLDLLQDWLADFRKSTSPSSAANPEELVAFDVVCGDFNFDNCSSDDKLEQQHTLFTH 531
Query: 187 ---PSLLDPYNMK------FEGTNPLIAKASGTSDNLNNSYSDPKQVKAY--PEGKRIDH 235
P L P K TN L + T DNL N S K K G+RID+
Sbjct: 532 YRDPCRLGPGEEKPWAIGTLLDTNGLYDEDVCTPDNLQNKSSGQKGRKELLKGNGRRIDY 591
Query: 236 ILFHTNH----SWEARVVNF 251
+L H W+A V F
Sbjct: 592 ML-HAEEGLCPDWKAEVEEF 610
>BC112238-1|AAI12239.1| 655|Homo sapiens sphingomyelin
phosphodiesterase 3, neutral membrane protein.
Length = 655
Score = 41.1 bits (92), Expect = 0.007
Identities = 41/141 (29%), Positives = 62/141 (43%), Gaps = 22/141 (15%)
Query: 36 NIVCLQEVWSEKDYLYLKENLKNVLPYSYY---FYS-------GVLGSGLCVFSKWVIQD 85
+ +CLQEV+ ++ LKE L Y Y Y L SGL S++ I D
Sbjct: 358 DFLCLQEVFDKRAATKLKEQLHGYFEYILYDVGVYGCQGCCSFKCLNSGLLFASRYPIMD 417
Query: 86 VFFHQWPLNGYIHKIHHGDWFGGKGVGLCRIKFG-----ERLIN-VYCTHLHAEYHEDDM 139
V +H +P +K + D KG +++ G +R++ + CTHLHA + +
Sbjct: 418 VAYHCYP-----NKC-NDDALASKGALFLKVQVGSTPQDQRIVGYIACTHLHAPQEDSAI 471
Query: 140 YLAHRVLQAYSTAEFVKLTSS 160
L A+F K TSS
Sbjct: 472 RCGQLDLLQDWLADFRKSTSS 492
>AJ250460-1|CAB92964.1| 655|Homo sapiens neutral sphingomyelinase
II protein.
Length = 655
Score = 41.1 bits (92), Expect = 0.007
Identities = 41/141 (29%), Positives = 62/141 (43%), Gaps = 22/141 (15%)
Query: 36 NIVCLQEVWSEKDYLYLKENLKNVLPYSYY---FYS-------GVLGSGLCVFSKWVIQD 85
+ +CLQEV+ ++ LKE L Y Y Y L SGL S++ I D
Sbjct: 358 DFLCLQEVFDKRAATKLKEQLHGYFEYILYDVGVYGCQGCCSFKCLNSGLLFASRYPIMD 417
Query: 86 VFFHQWPLNGYIHKIHHGDWFGGKGVGLCRIKFG-----ERLIN-VYCTHLHAEYHEDDM 139
V +H +P +K + D KG +++ G +R++ + CTHLHA + +
Sbjct: 418 VAYHCYP-----NKC-NDDALASKGALFLKVQVGSTPQDQRIVGYIACTHLHAPQEDSAI 471
Query: 140 YLAHRVLQAYSTAEFVKLTSS 160
L A+F K TSS
Sbjct: 472 RCGQLDLLQDWLADFRKSTSS 492
>BC064593-1|AAH64593.1| 385|Homo sapiens DCP2 protein protein.
Length = 385
Score = 32.7 bits (71), Expect = 2.4
Identities = 25/90 (27%), Positives = 45/90 (50%), Gaps = 8/90 (8%)
Query: 204 IAKASGTSDNLNNSYSDPKQVKAYPEGKRIDHILFHTNHSWEARVVNFGNP----LPDRV 259
+++ G S + +N +S A P +++ F HS + + G+P + R
Sbjct: 239 LSRRFGDSSDSDNGFSSTGSTPAKPTVEKLSRTKFR--HSQQ--LFPDGSPGDQWVKHRQ 294
Query: 260 PEQQFSYSDHNAVSLELHLKPCEQKLNQRQ 289
P QQ Y++H+ +S L K CE+KL+ R+
Sbjct: 295 PLQQKPYNNHSEMSDLLKGKKCEKKLHPRK 324
>BC112210-1|AAI12211.1| 474|Homo sapiens PRAME family member 10
protein.
Length = 474
Score = 31.1 bits (67), Expect = 7.2
Identities = 13/41 (31%), Positives = 25/41 (60%)
Query: 345 YDVLKLLITALCFYNLVMGSLWNQIEMNSLKAGLNALENFI 385
++ LKL++ A F +L +GSL + + +L+A L L+ +
Sbjct: 49 FEALKLMVQAWPFLSLPLGSLMKTLHLETLQAVLRGLDTLV 89
>BC112208-1|AAI12209.1| 474|Homo sapiens PRAME family member 10
protein.
Length = 474
Score = 31.1 bits (67), Expect = 7.2
Identities = 13/41 (31%), Positives = 25/41 (60%)
Query: 345 YDVLKLLITALCFYNLVMGSLWNQIEMNSLKAGLNALENFI 385
++ LKL++ A F +L +GSL + + +L+A L L+ +
Sbjct: 49 FEALKLMVQAWPFLSLPLGSLMKTLHLETLQAVLRGLDTLV 89
>AL049682-1|CAB41254.1| 459|Homo sapiens hypothetical protein
protein.
Length = 459
Score = 31.1 bits (67), Expect = 7.2
Identities = 13/41 (31%), Positives = 25/41 (60%)
Query: 345 YDVLKLLITALCFYNLVMGSLWNQIEMNSLKAGLNALENFI 385
++ LKL++ A F +L +GSL + + +L+A L L+ +
Sbjct: 49 FEALKLMVQAWPFLSLPLGSLMKTLHLETLQAVLRGLDTLV 89
>AL022101-3|CAA17876.1| 459|Homo sapiens PRAME family member 10
protein.
Length = 459
Score = 31.1 bits (67), Expect = 7.2
Identities = 13/41 (31%), Positives = 25/41 (60%)
Query: 345 YDVLKLLITALCFYNLVMGSLWNQIEMNSLKAGLNALENFI 385
++ LKL++ A F +L +GSL + + +L+A L L+ +
Sbjct: 49 FEALKLMVQAWPFLSLPLGSLMKTLHLETLQAVLRGLDTLV 89
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.320 0.137 0.421
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 61,207,678
Number of Sequences: 224733
Number of extensions: 2730751
Number of successful extensions: 5568
Number of sequences better than 10.0: 13
Number of HSP's better than 10.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 5548
Number of HSP's gapped (non-prelim): 14
length of query: 404
length of database: 73,234,838
effective HSP length: 92
effective length of query: 312
effective length of database: 52,559,402
effective search space: 16398533424
effective search space used: 16398533424
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.8 bits)
S2: 66 (30.7 bits)
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