Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001137-TA|BGIBMGA001137-PA|IPR000398|Thymidylate
synthase
(253 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P04818 Cluster: Thymidylate synthase; n=129; root|Rep: ... 397 e-109
UniRef50_Q4U9G5 Cluster: Bifunctional dihydrofolate reductase/th... 351 1e-95
UniRef50_O96650 Cluster: Thymidylate synthase; n=14; root|Rep: T... 350 2e-95
UniRef50_P12461 Cluster: Thymidylate synthase; n=14; Ascomycota|... 348 9e-95
UniRef50_Q9UTI7 Cluster: Thymidylate synthase; n=3; Eukaryota|Re... 346 4e-94
UniRef50_Q4PBV6 Cluster: Thymidylate synthase; n=1; Ustilago may... 346 4e-94
UniRef50_Q4A320 Cluster: Bifunctional dihydrofolate reductase-th... 331 1e-89
UniRef50_P07382 Cluster: Bifunctional dihydrofolate reductase-th... 330 2e-89
UniRef50_Q2TA32 Cluster: Thymidylate synthase; n=4; cellular org... 328 8e-89
UniRef50_Q27828 Cluster: Bifunctional dihydrofolate reductase-th... 327 1e-88
UniRef50_Q07422 Cluster: Bifunctional dihydrofolate reductase-th... 323 2e-87
UniRef50_Q27713 Cluster: Bifunctional dihydrofolate reductase-th... 322 4e-87
UniRef50_Q5CPQ4 Cluster: Dihydrofolate reductase-thymidylate syn... 301 1e-80
UniRef50_Q0INI0 Cluster: Os12g0446900 protein; n=11; cellular or... 274 1e-72
UniRef50_A3QU09 Cluster: Thymidylate synthase; n=1; Oryctes rhin... 270 3e-71
UniRef50_Q8WYK4 Cluster: Thymidylate synthase; n=12; Deuterostom... 263 3e-69
UniRef50_O33380 Cluster: Thymidylate synthase; n=116; cellular o... 243 4e-63
UniRef50_Q8G3T9 Cluster: Thymidylate synthase; n=287; root|Rep: ... 238 1e-61
UniRef50_Q5UQG3 Cluster: Bifunctional dihydrofolate reductase-th... 228 1e-58
UniRef50_Q81R23 Cluster: Thymidylate synthase; n=68; cellular or... 216 5e-55
UniRef50_P78029 Cluster: Thymidylate synthase; n=20; Bacteria|Re... 214 2e-54
UniRef50_Q9Z671 Cluster: Thymidylate synthase; n=9; Alphaproteob... 213 5e-54
UniRef50_Q8WYK3 Cluster: Thymidylate synthase; n=4; Eutheria|Rep... 210 3e-53
UniRef50_Q0FG99 Cluster: Thymidylate synthase; n=3; root|Rep: Th... 203 4e-51
UniRef50_Q67JQ1 Cluster: Thymidylate synthase; n=1; Symbiobacter... 201 1e-50
UniRef50_Q76YC2 Cluster: DTMP synthase; n=1; Aeromonas phage Aeh... 193 4e-48
UniRef50_Q8MVZ9 Cluster: Bifunctional dihydrofolate reductase-th... 188 2e-46
UniRef50_A5KSZ1 Cluster: Thymidylate synthase; n=1; candidate di... 184 2e-45
UniRef50_P00471 Cluster: Thymidylate synthase; n=17; Viruses|Rep... 179 7e-44
UniRef50_Q2S5G7 Cluster: Thymidylate synthase; n=8; Bacteria|Rep... 173 5e-42
UniRef50_P42326 Cluster: Thymidylate synthase A; n=9; root|Rep: ... 171 1e-41
UniRef50_Q6QGJ5 Cluster: Putative thymidylate synthase; n=1; Ent... 170 3e-41
UniRef50_Q97EV3 Cluster: Thymidylate synthase; n=2; Clostridium|... 162 9e-39
UniRef50_Q7Y427 Cluster: DTMP (Thymidylate) synthase; n=1; Enter... 156 6e-37
UniRef50_Q6WIC0 Cluster: DTMP (Thymidylate) synthase; n=1; Vibri... 153 5e-36
UniRef50_Q6KGF1 Cluster: Putative thymidylate synthase; n=1; Ent... 141 2e-32
UniRef50_Q7WP13 Cluster: Thymidylate synthase; n=43; Proteobacte... 136 4e-31
UniRef50_Q8MVZ8 Cluster: Bifunctional dihydrofolate reductase-th... 122 7e-27
UniRef50_Q3F0X9 Cluster: Thymidylate synthase; n=1; Bacillus thu... 120 4e-26
UniRef50_Q87SA0 Cluster: Thymidylate synthase; n=76; Proteobacte... 119 8e-26
UniRef50_Q8MW00 Cluster: Bifunctional dihydrofolate reductase-th... 118 1e-25
UniRef50_Q3IQP2 Cluster: Thymidylate synthase; n=4; Halobacteria... 115 1e-24
UniRef50_Q8MVZ6 Cluster: Bifunctional dihydrofolate reductase-th... 114 2e-24
UniRef50_Q8MVZ5 Cluster: Bifunctional dihydrofolate reductase-th... 111 2e-23
UniRef50_A5Z9U8 Cluster: Thymidylate synthase; n=9; Bacteria|Rep... 106 6e-22
UniRef50_Q8SCS7 Cluster: PHIKZ235; n=1; Pseudomonas phage phiKZ|... 103 3e-21
UniRef50_Q8RGP6 Cluster: Thymidylate synthase; n=3; Fusobacteriu... 98 2e-19
UniRef50_Q934U8 Cluster: Putative thymidylate synthase; n=1; Sal... 91 2e-17
UniRef50_A2SMX7 Cluster: Putative thymidylate synthase; n=1; Met... 88 2e-16
UniRef50_Q8DUI4 Cluster: Thymidylate synthase; n=45; Streptococc... 69 1e-10
UniRef50_A0ITX4 Cluster: Thymidylate synthase; n=1; Serratia pro... 64 2e-09
UniRef50_Q2FCV1 Cluster: Thymidylate synthase; n=1; Acinetobacte... 63 6e-09
UniRef50_A3RUA7 Cluster: Deoxyuridylate hydroxymethyltransferase... 63 7e-09
UniRef50_Q1YFG6 Cluster: Possible thymidylate synthase; n=1; Aur... 57 4e-07
UniRef50_A7TUR1 Cluster: Putative thymidylate synthase; n=1; Str... 56 1e-06
UniRef50_Q8THH4 Cluster: Thymidylate synthase; n=6; Methanosarci... 54 3e-06
UniRef50_Q21ZJ9 Cluster: Thymidylate synthase; n=1; Rhodoferax f... 53 8e-06
UniRef50_P31654 Cluster: Deoxyuridylate hydroxymethyltransferase... 52 1e-05
UniRef50_O28232 Cluster: Thymidylate synthase, putative; n=1; Ar... 49 1e-04
UniRef50_UPI00015972C9 Cluster: hypothetical protein RBAM_005690... 48 2e-04
UniRef50_O26868 Cluster: Thymidylate synthase; n=3; Methanotherm... 46 7e-04
UniRef50_A5FR57 Cluster: Thymidylate synthase-like protein; n=3;... 45 0.002
UniRef50_Q57931 Cluster: Thymidylate synthase; n=6; Methanococca... 44 0.003
UniRef50_A3CSY2 Cluster: Thymidylate synthase; n=3; Methanomicro... 44 0.004
UniRef50_Q5DN81 Cluster: Thymidylate synthase; n=2; unclassified... 43 0.006
UniRef50_Q2T5Q0 Cluster: Deoxyuridylate hydroxymethyltransferase... 43 0.009
UniRef50_A1IF84 Cluster: Thymidylate synthase; n=1; Candidatus D... 42 0.015
UniRef50_A7FS25 Cluster: Thymidylate synthase; n=4; Clostridium ... 41 0.035
UniRef50_A5KRW4 Cluster: Thymidylate synthase-like protein; n=1;... 40 0.060
UniRef50_Q4C4J0 Cluster: Thymidylate synthase; n=1; Crocosphaera... 40 0.080
UniRef50_Q52PP0 Cluster: Putative thymidylate synthase; n=1; Xan... 39 0.11
UniRef50_Q2NEY9 Cluster: ThyA; n=1; Methanosphaera stadtmanae DS... 37 0.56
UniRef50_Q5QC34 Cluster: RB69 orf048c-like; n=3; Viruses|Rep: RB... 34 3.0
UniRef50_Q6IIS4 Cluster: HDC17231; n=1; Drosophila melanogaster|... 34 3.0
UniRef50_Q0KHA0 Cluster: Embryonic ectoderm development protein;... 34 3.0
UniRef50_Q5KLQ8 Cluster: Cell growth and/or maintenance-related ... 34 3.0
UniRef50_Q0UYZ8 Cluster: Predicted protein; n=1; Phaeosphaeria n... 34 4.0
UniRef50_A7TG56 Cluster: Putative uncharacterized protein; n=1; ... 33 5.2
UniRef50_Q8TVL9 Cluster: Thymidylate synthase; n=1; Methanopyrus... 33 5.2
UniRef50_UPI00015B59CF Cluster: PREDICTED: similar to coagulatio... 33 6.9
UniRef50_Q7PUX5 Cluster: ENSANGP00000011675; n=1; Anopheles gamb... 33 6.9
UniRef50_A1ZKR9 Cluster: Putative uncharacterized protein; n=1; ... 33 9.2
UniRef50_Q2FKU7 Cluster: Thymidylate synthase-like; n=1; Methano... 33 9.2
>UniRef50_P04818 Cluster: Thymidylate synthase; n=129; root|Rep:
Thymidylate synthase - Homo sapiens (Human)
Length = 313
Score = 397 bits (977), Expect = e-109
Identities = 178/251 (70%), Positives = 209/251 (83%), Gaps = 1/251 (0%)
Query: 3 RYSLHNNTLPLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLG 62
RYSL + PLLT KRVF +GV+EELLW I GST++K L++KGV IWDANGSR+FLD+LG
Sbjct: 64 RYSLRDE-FPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLG 122
Query: 63 FTDREEGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAW 122
F+ REEGDLGPVYGFQWRH GA+Y D ++DY+GQG+DQLQ VID+IK NP DRR+++CAW
Sbjct: 123 FSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAW 182
Query: 123 NSSDLKKMALPPCHCLAQFYVADGKLSCLLYQRSADMGLGVPFNIASYSLLTHMIAHVTG 182
N DL MALPPCH L QFYV + +LSC LYQRS DMGLGVPFNIASY+LLT+MIAH+TG
Sbjct: 183 NPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITG 242
Query: 183 YQAGEFIHTTGDTHVYLNHIEPLKIQLQREPKQFPTLEFARKIESIDDFKYEDFIIKDYK 242
+ G+FIHT GD H+YLNHIEPLKIQLQREP+ FP L RK+E IDDFK EDF I+ Y
Sbjct: 243 LKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYN 302
Query: 243 PHPKIEMEMAV 253
PHP I+MEMAV
Sbjct: 303 PHPTIKMEMAV 313
>UniRef50_Q4U9G5 Cluster: Bifunctional dihydrofolate
reductase/thymidilate synthase, putative; n=4;
Piroplasmida|Rep: Bifunctional dihydrofolate
reductase/thymidilate synthase, putative - Theileria
annulata
Length = 523
Score = 351 bits (862), Expect = 1e-95
Identities = 155/250 (62%), Positives = 194/250 (77%), Gaps = 1/250 (0%)
Query: 3 RYSLHNNTLPLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLG 62
R+ L + + PLLT K+VF RG+IEEL+W I GST+ L K V IW+ NG+R+FLDNLG
Sbjct: 274 RFDL-SQSFPLLTTKKVFLRGIIEELIWFIRGSTNGNELLKKNVRIWELNGARSFLDNLG 332
Query: 63 FTDREEGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAW 122
F DREE DLGPVYGFQWRH GAKYID DYT QGIDQL VI+ IKNNP +RR+++C+W
Sbjct: 333 FYDREEQDLGPVYGFQWRHFGAKYIDMHADYTDQGIDQLSLVIERIKNNPDNRRLIVCSW 392
Query: 123 NSSDLKKMALPPCHCLAQFYVADGKLSCLLYQRSADMGLGVPFNIASYSLLTHMIAHVTG 182
N +DL KMALPPCH L QF+VADG LSC+++QRS DMGLGVPFNIASYSLLT+MIAH+ G
Sbjct: 393 NVADLSKMALPPCHLLFQFFVADGTLSCMMHQRSCDMGLGVPFNIASYSLLTYMIAHICG 452
Query: 183 YQAGEFIHTTGDTHVYLNHIEPLKIQLQREPKQFPTLEFARKIESIDDFKYEDFIIKDYK 242
+ GEF+H GD H+Y NHI+ +K Q+ R P FPTL+ ++I I+DF +D +++Y+
Sbjct: 453 LKPGEFVHNLGDAHIYNNHIDAIKEQISRVPYPFPTLKLNKEITRIEDFTIDDIKVENYR 512
Query: 243 PHPKIEMEMA 252
HP I+MEMA
Sbjct: 513 CHPLIKMEMA 522
>UniRef50_O96650 Cluster: Thymidylate synthase; n=14; root|Rep:
Thymidylate synthase - Ascaris suum (Pig roundworm)
(Ascaris lumbricoides)
Length = 294
Score = 350 bits (860), Expect = 2e-95
Identities = 159/250 (63%), Positives = 186/250 (74%)
Query: 4 YSLHNNTLPLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGF 63
YSL N +PLLT KRV+ +GV+EELLW I G TD+K L+AKGV IWDANGSR FLD+ GF
Sbjct: 45 YSLRNGVIPLLTTKRVYWKGVVEELLWFIKGDTDAKRLSAKGVKIWDANGSREFLDSQGF 104
Query: 64 TDREEGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWN 123
DR EGDLGP+YGFQWRH GA+Y DY GQG+DQL VI+ IKNNP RR+++ AWN
Sbjct: 105 KDRPEGDLGPIYGFQWRHFGAEYHGTDADYKGQGVDQLADVIEQIKNNPNSRRIILNAWN 164
Query: 124 SSDLKKMALPPCHCLAQFYVADGKLSCLLYQRSADMGLGVPFNIASYSLLTHMIAHVTGY 183
DL +MALPPCH LAQF V +G+LSC LYQRS DMGLGVPFN+ASY LLTHMIAHV
Sbjct: 165 VKDLHQMALPPCHTLAQFAVKNGELSCQLYQRSGDMGLGVPFNLASYGLLTHMIAHVCAL 224
Query: 184 QAGEFIHTTGDTHVYLNHIEPLKIQLQREPKQFPTLEFARKIESIDDFKYEDFIIKDYKP 243
+ G H GD HVYLNHI+ LK QL R+P+ FPT+ F +I+SIDDF E I+ Y P
Sbjct: 225 KTGFLHHVLGDAHVYLNHIDALKEQLSRDPRPFPTVHFEGRIDSIDDFTAESIILNGYNP 284
Query: 244 HPKIEMEMAV 253
I+M MAV
Sbjct: 285 MAPIKMPMAV 294
>UniRef50_P12461 Cluster: Thymidylate synthase; n=14;
Ascomycota|Rep: Thymidylate synthase - Candida albicans
(Yeast)
Length = 315
Score = 348 bits (855), Expect = 9e-95
Identities = 167/272 (61%), Positives = 196/272 (72%), Gaps = 21/272 (7%)
Query: 3 RYSLHNNTLPLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLG 62
R+ L N+T PLLT K+VF++G+I ELLW ++GSTD+K L+ KGV IW+ NGSR FLD LG
Sbjct: 44 RFDLSNDTFPLLTTKKVFSKGIIHELLWFVAGSTDAKILSEKGVKIWEGNGSREFLDKLG 103
Query: 63 FTDREEGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAW 122
T R EGDLGPVYGFQWRH GA+Y DC +DYTGQG DQLQ VI +K NP DRR+++ AW
Sbjct: 104 LTHRREGDLGPVYGFQWRHFGAEYKDCDSDYTGQGFDQLQDVIKKLKTNPYDRRIIMSAW 163
Query: 123 NSSDLKKMALPPCHCLAQFYV-----------------ADGKLSCLLYQRSADMGLGVPF 165
N D KMALPPCH QFYV A KLSCLLYQRS DMGLGVPF
Sbjct: 164 NPPDFAKMALPPCHVFCQFYVNFPTSSPDPNNPKQAKTAKPKLSCLLYQRSCDMGLGVPF 223
Query: 166 NIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVYLNHIEPLKIQLQREPKQFPTL----EF 221
NIASY+LLT MIAHV GEFIHT GD HVYL+HI+ LK Q +R PKQFP L E
Sbjct: 224 NIASYALLTKMIAHVVDMDCGEFIHTLGDAHVYLDHIDALKEQFERIPKQFPKLVIKEER 283
Query: 222 ARKIESIDDFKYEDFIIKDYKPHPKIEMEMAV 253
+I+SIDDFK+EDF I Y+P+P I+M+M+V
Sbjct: 284 KNEIKSIDDFKFEDFEIVGYEPYPPIKMKMSV 315
>UniRef50_Q9UTI7 Cluster: Thymidylate synthase; n=3; Eukaryota|Rep:
Thymidylate synthase - Schizosaccharomyces pombe
(Fission yeast)
Length = 625
Score = 346 bits (850), Expect = 4e-94
Identities = 158/261 (60%), Positives = 198/261 (75%), Gaps = 10/261 (3%)
Query: 3 RYSLHNNTLPLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLG 62
R+SL NNTLPLLT KRVF RGV+EELLW I G T++ L+ KG+HIWD NGSR FLD+ G
Sbjct: 365 RFSLRNNTLPLLTTKRVFLRGVLEELLWFIHGDTNANHLSEKGIHIWDGNGSREFLDSRG 424
Query: 63 FTDREEGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAW 122
TDR+ GDLGP+YGFQWRH GA+Y+DC TDYT +G+DQL VI ++K NP DRR+++ AW
Sbjct: 425 LTDRKVGDLGPIYGFQWRHFGAQYVDCDTDYTNKGVDQLAQVISTLKLNPYDRRIILSAW 484
Query: 123 NSSDLKKMALPPCHCLAQFYVAD-----GK--LSCLLYQRSADMGLGVPFNIASYSLLTH 175
N + +MALPPCH QFYV++ GK LS ++YQRSADMGLGVPFNIASYSLLTH
Sbjct: 485 NPLAIPEMALPPCHIFCQFYVSEPCKPGGKPQLSSMMYQRSADMGLGVPFNIASYSLLTH 544
Query: 176 MIAHVTGYQAGEFIHTTGDTHVYLNHIEPLKIQLQREPKQFPTLEF---ARKIESIDDFK 232
MIAH+ GY+A EF+H GD H+Y +H+E L+ QL+R PK FP L F A+ I SID F
Sbjct: 545 MIAHMCGYEAAEFVHVMGDCHIYNDHLEALQTQLERVPKAFPKLFFKRDAKDIGSIDSFS 604
Query: 233 YEDFIIKDYKPHPKIEMEMAV 253
+DF ++ Y P+ I+M+M+V
Sbjct: 605 VDDFAVEGYNPYGPIKMKMSV 625
>UniRef50_Q4PBV6 Cluster: Thymidylate synthase; n=1; Ustilago
maydis|Rep: Thymidylate synthase - Ustilago maydis (Smut
fungus)
Length = 554
Score = 346 bits (850), Expect = 4e-94
Identities = 159/261 (60%), Positives = 195/261 (74%), Gaps = 10/261 (3%)
Query: 3 RYSLHNNTLPLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLG 62
R+ L N TLPLLT KRVF RGV+EELLW + G TD+K L K VHIWD NGSR FLD+ G
Sbjct: 294 RFDLTNGTLPLLTTKRVFFRGVLEELLWFVGGKTDAKLLTEKSVHIWDGNGSRAFLDSRG 353
Query: 63 FTDREEGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAW 122
+ R EGDLGPVYGFQWRH GA Y DC TDY GQG+DQL SVID I+NNP DRR+L+ AW
Sbjct: 354 LSHRREGDLGPVYGFQWRHFGATYKDCDTDYAGQGVDQLASVIDKIRNNPTDRRILLSAW 413
Query: 123 NSSDLKKMALPPCHCLAQFYVAD--------GK--LSCLLYQRSADMGLGVPFNIASYSL 172
N +DL+ MALPPCH AQF+V++ GK LSC +YQRS D+GLGVPFNIASY+L
Sbjct: 414 NPADLELMALPPCHMFAQFFVSNLDAYSKGQGKKHLSCQMYQRSCDLGLGVPFNIASYAL 473
Query: 173 LTHMIAHVTGYQAGEFIHTTGDTHVYLNHIEPLKIQLQREPKQFPTLEFARKIESIDDFK 232
LT+MIA VT + E I GD HVY +H++PLK QL+R+P FP L+ R ++ IDDF
Sbjct: 474 LTYMIAKVTDCEPKELILAMGDAHVYKDHVQPLKAQLERDPLPFPKLKIERDVKDIDDFT 533
Query: 233 YEDFIIKDYKPHPKIEMEMAV 253
++DF+++ YK H KI+M+M+V
Sbjct: 534 FDDFVVQGYKCHGKIDMKMSV 554
>UniRef50_Q4A320 Cluster: Bifunctional dihydrofolate
reductase-thymidylate synthase; n=1; Emiliania huxleyi
virus 86|Rep: Bifunctional dihydrofolate
reductase-thymidylate synthase - Emiliania huxleyi virus
86
Length = 480
Score = 331 bits (813), Expect = 1e-89
Identities = 150/250 (60%), Positives = 184/250 (73%), Gaps = 1/250 (0%)
Query: 3 RYSLHNNTLPLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLG 62
R++L + PLLT KR + +G++EELLW I GST++ LAAK V IWD NGSR+FLD++G
Sbjct: 231 RFNLSTH-FPLLTTKRTYWKGIVEELLWFIRGSTNANELAAKNVKIWDGNGSRDFLDSVG 289
Query: 63 FTDREEGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAW 122
D EEGDLGPVYGFQWRH GA Y Y QG DQLQ+VID IKNNP RR+++ AW
Sbjct: 290 LVDNEEGDLGPVYGFQWRHFGADYKTMHDSYDSQGTDQLQNVIDQIKNNPTSRRIIMSAW 349
Query: 123 NSSDLKKMALPPCHCLAQFYVADGKLSCLLYQRSADMGLGVPFNIASYSLLTHMIAHVTG 182
N + L+KMALPPCH + QFYV DG LSC +YQRSAD+GLGVPFNIASY+LLT +IAH T
Sbjct: 350 NPNALEKMALPPCHLMCQFYVHDGMLSCQMYQRSADIGLGVPFNIASYALLTCLIAHFTN 409
Query: 183 YQAGEFIHTTGDTHVYLNHIEPLKIQLQREPKQFPTLEFARKIESIDDFKYEDFIIKDYK 242
+ GEFIH GD HVY NHI+ LK QL+R+P FPT+ ++I D +D I+ DYK
Sbjct: 410 LKPGEFIHVIGDAHVYTNHIDALKTQLKRKPYDFPTIHINNMPKTIFDVTSDDIILNDYK 469
Query: 243 PHPKIEMEMA 252
HPKI M+M+
Sbjct: 470 CHPKIHMDMS 479
>UniRef50_P07382 Cluster: Bifunctional dihydrofolate
reductase-thymidylate synthase (DHFR-TS) [Includes:
Dihydrofolate reductase (EC 1.5.1.3); Thymidylate
synthase (EC 2.1.1.45)]; n=28; Trypanosomatidae|Rep:
Bifunctional dihydrofolate reductase-thymidylate
synthase (DHFR-TS) [Includes: Dihydrofolate reductase
(EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)] -
Leishmania major
Length = 520
Score = 330 bits (812), Expect = 2e-89
Identities = 149/253 (58%), Positives = 188/253 (74%), Gaps = 2/253 (0%)
Query: 3 RYSLHNNTLPLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLG 62
R+SL +N LPLLT KRVF RGV EELLW + G T ++ LA K +HIWD NGSR FLD+ G
Sbjct: 268 RFSLRDNRLPLLTTKRVFWRGVCEELLWFLRGETSAQLLADKDIHIWDGNGSREFLDSRG 327
Query: 63 FTDREEGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAW 122
T+ +E DLGPVYGFQWRH GA Y + +Y G+G+DQ++ ++++IK NP DRR+L+ AW
Sbjct: 328 LTENKEMDLGPVYGFQWRHFGADYKGFEANYDGEGVDQIKLIVETIKTNPNDRRLLVTAW 387
Query: 123 NSSDLKKMALPPCHCLAQFYV--ADGKLSCLLYQRSADMGLGVPFNIASYSLLTHMIAHV 180
N L+KMALPPCH LAQFYV +LSC+LYQRS DMGLGVPFNIASY+LLT +IA
Sbjct: 388 NPCALQKMALPPCHLLAQFYVNTDTSELSCMLYQRSCDMGLGVPFNIASYALLTILIAKA 447
Query: 181 TGYQAGEFIHTTGDTHVYLNHIEPLKIQLQREPKQFPTLEFARKIESIDDFKYEDFIIKD 240
TG + GE +HT GD HVY NH++ LK QL+R P FPTL F + + ++D++ D + D
Sbjct: 448 TGLRPGELVHTLGDAHVYRNHVDALKAQLERVPHAFPTLIFKEERQYLEDYELTDMEVID 507
Query: 241 YKPHPKIEMEMAV 253
Y PHP I+MEMAV
Sbjct: 508 YVPHPAIKMEMAV 520
>UniRef50_Q2TA32 Cluster: Thymidylate synthase; n=4; cellular
organisms|Rep: Thymidylate synthase - Bos taurus
(Bovine)
Length = 354
Score = 328 bits (806), Expect = 8e-89
Identities = 145/210 (69%), Positives = 173/210 (82%), Gaps = 1/210 (0%)
Query: 3 RYSLHNNTLPLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLG 62
RY+L + PLLT KRVF +GV+EELLW I GST++K L++KGV IWDANGSR+FLD LG
Sbjct: 67 RYNLRDE-FPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDGLG 125
Query: 63 FTDREEGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAW 122
F+DR EGDLGPVYGFQWRH GA+Y D ++Y+GQG+DQLQ VID+IK NP DRR+++CAW
Sbjct: 126 FSDRAEGDLGPVYGFQWRHFGAEYKDMDSEYSGQGVDQLQKVIDTIKTNPNDRRIILCAW 185
Query: 123 NSSDLKKMALPPCHCLAQFYVADGKLSCLLYQRSADMGLGVPFNIASYSLLTHMIAHVTG 182
N DL MALPPCH L QFYV +G+LSC LYQRS DMGLGVPFNIASY+LLT+MIAH+T
Sbjct: 186 NPKDLPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITD 245
Query: 183 YQAGEFIHTTGDTHVYLNHIEPLKIQLQRE 212
+ G+F+HT GD H+YLNHIEPLK Q E
Sbjct: 246 LKPGDFVHTLGDAHIYLNHIEPLKTQALME 275
Score = 65.3 bits (152), Expect = 1e-09
Identities = 28/46 (60%), Positives = 37/46 (80%)
Query: 208 QLQREPKQFPTLEFARKIESIDDFKYEDFIIKDYKPHPKIEMEMAV 253
+LQREP+ FP L+ RK+E+IDDF+ EDF I+ Y P+P I+MEMAV
Sbjct: 309 ELQREPRPFPKLKILRKVETIDDFQAEDFQIEGYNPNPTIKMEMAV 354
>UniRef50_Q27828 Cluster: Bifunctional dihydrofolate
reductase-thymidylate synthase (DHFR-TS) [Includes:
Dihydrofolate reductase (EC 1.5.1.3); Thymidylate
synthase (EC 2.1.1.45)]; n=15; Paramecium|Rep:
Bifunctional dihydrofolate reductase-thymidylate
synthase (DHFR-TS) [Includes: Dihydrofolate reductase
(EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)] -
Paramecium tetraurelia
Length = 462
Score = 327 bits (804), Expect = 1e-88
Identities = 142/244 (58%), Positives = 185/244 (75%), Gaps = 1/244 (0%)
Query: 10 TLPLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEG 69
+ PLLT K+VF RGV+EELLW + G+T+ K L KGV IW+ NG+R +LD +G R+E
Sbjct: 220 SFPLLTTKKVFFRGVVEELLWFLRGNTNGKLLLDKGVKIWEGNGTREYLDTIGLQHRQEH 279
Query: 70 DLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWNSSDLKK 129
DLGPVYGFQWRH GAKY DCQTDY+ QG+DQ++ +I +KNNP RR+++ AWN DLK+
Sbjct: 280 DLGPVYGFQWRHFGAKYKDCQTDYSNQGVDQVKEIIQLLKNNPDSRRIILSAWNPIDLKQ 339
Query: 130 MALPPCHCLAQFYVADGKLSCLLYQRSADMGLGVPFNIASYSLLTHMIAHVTGYQAGEFI 189
MALPPCH ++QF+VA+GKLSC++YQRS D GLG+PFNIASY+LLT+M+A GEF+
Sbjct: 340 MALPPCHVMSQFFVANGKLSCMMYQRSCDFGLGIPFNIASYALLTYMLAKECNLNLGEFV 399
Query: 190 HTTGDTHVYLNHIEPLKIQLQREPKQFPTLEFARKIESIDDFKYEDFIIKDYKPHPKIEM 249
H GDTH+Y NH+E LK Q++R P FP L+ + +S+ D+ YEDF + Y H KIEM
Sbjct: 400 HVLGDTHIYSNHVEALKKQIERVPYPFPLLKI-KGNKSLFDYTYEDFELVGYNAHDKIEM 458
Query: 250 EMAV 253
+MAV
Sbjct: 459 KMAV 462
>UniRef50_Q07422 Cluster: Bifunctional dihydrofolate
reductase-thymidylate synthase (DHFR-TS) [Includes:
Dihydrofolate reductase (EC 1.5.1.3); Thymidylate
synthase (EC 2.1.1.45)]; n=1; Toxoplasma gondii|Rep:
Bifunctional dihydrofolate reductase-thymidylate
synthase (DHFR-TS) [Includes: Dihydrofolate reductase
(EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)] -
Toxoplasma gondii
Length = 610
Score = 323 bits (794), Expect = 2e-87
Identities = 154/254 (60%), Positives = 185/254 (72%), Gaps = 4/254 (1%)
Query: 3 RYSLHNNTLPLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLG 62
RYSL + PLLT KRVF +GV+EELLW I G T++ L+ KGV IWD N +R FLD+
Sbjct: 358 RYSL-DQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRN 416
Query: 63 FTDREEGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAW 122
RE GD+GP YGFQWRH GA Y D TDYTGQG+DQL++VI ++ NP DRRML+ AW
Sbjct: 417 LPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAW 476
Query: 123 NSSDLKKMALPPCHCLAQFYVADGK-LSCLLYQRSADMGLGVPFNIASYSLLTHMIAHVT 181
N + L +MALPPCH L QFYV D K LSC++YQRS D+GLGVPFNIASYSLLT M+AHV
Sbjct: 477 NPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVC 536
Query: 182 GYQAGEFIHTTGDTHVYLNHIEPLKIQLQREPKQFPTLEFARK--IESIDDFKYEDFIIK 239
+ EFIH G+THVY NH+E LK QL+REP+ FP + K I+ IDDF EDF +
Sbjct: 537 NLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVV 596
Query: 240 DYKPHPKIEMEMAV 253
Y PH +I+MEMAV
Sbjct: 597 GYVPHGRIQMEMAV 610
>UniRef50_Q27713 Cluster: Bifunctional dihydrofolate
reductase-thymidylate synthase (DHFR-TS) [Includes:
Dihydrofolate reductase (EC 1.5.1.3); Thymidylate
synthase (EC 2.1.1.45)]; n=49; Plasmodium|Rep:
Bifunctional dihydrofolate reductase-thymidylate
synthase (DHFR-TS) [Includes: Dihydrofolate reductase
(EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)] -
Plasmodium berghei (strain Anka)
Length = 587
Score = 322 bits (792), Expect = 4e-87
Identities = 145/252 (57%), Positives = 183/252 (72%), Gaps = 1/252 (0%)
Query: 1 MQRYSLHNNTLPLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDN 60
M +++L N PLLT K++F RG+IEELLW I G T+ L K V IW+ANG+R FLDN
Sbjct: 336 MMKFNL-NEYFPLLTTKKLFIRGIIEELLWFIRGETNGNTLLEKNVRIWEANGTREFLDN 394
Query: 61 LGFTDREEGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLIC 120
RE DLGP+YGFQWRH GA+Y D +Y +G+DQL+++I+ IKN+P RR+++C
Sbjct: 395 RKLFHREVNDLGPIYGFQWRHFGAEYTDMHDNYKDKGVDQLKNIINLIKNDPTCRRIILC 454
Query: 121 AWNSSDLKKMALPPCHCLAQFYVADGKLSCLLYQRSADMGLGVPFNIASYSLLTHMIAHV 180
AWN +L +MALPPCH L QFYV DGKLSC++YQRS D+GLGVPFNIASYS+ T+MIA V
Sbjct: 455 AWNVKNLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTYMIAQV 514
Query: 181 TGYQAGEFIHTTGDTHVYLNHIEPLKIQLQREPKQFPTLEFARKIESIDDFKYEDFIIKD 240
QA EFIH G+ HVY NHIE LKIQL R P FPTL+ I++I+DF DF +++
Sbjct: 515 CNLQAAEFIHVLGNAHVYNNHIESLKIQLNRTPYPFPTLKLNPDIKNIEDFTISDFTVQN 574
Query: 241 YKPHPKIEMEMA 252
Y H KI M+MA
Sbjct: 575 YVHHDKINMDMA 586
>UniRef50_Q5CPQ4 Cluster: Dihydrofolate reductase-thymidylate
synthase; n=14; cellular organisms|Rep: Dihydrofolate
reductase-thymidylate synthase - Cryptosporidium parvum
Iowa II
Length = 531
Score = 301 bits (738), Expect = 1e-80
Identities = 136/254 (53%), Positives = 176/254 (69%), Gaps = 2/254 (0%)
Query: 1 MQRYSLHNNTLPLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDN 60
M R+ + + PLLT K+V R + EEL+W I G T+ L K V+IW NGS+ +L+
Sbjct: 279 MMRFDMRES-FPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLER 337
Query: 61 LGFTDREEGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLIC 120
+G REE DLGP+YGFQWRH +Y DYTG G+DQL +I+++KNNP DRR ++
Sbjct: 338 IGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILT 397
Query: 121 AWNSSDLKKMALPPCHCLAQFYVA-DGKLSCLLYQRSADMGLGVPFNIASYSLLTHMIAH 179
AWN S L +MALPPCH L+Q+YV D LSC LYQRS D+GLG PFNIASY++LT M+A
Sbjct: 398 AWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQ 457
Query: 180 VTGYQAGEFIHTTGDTHVYLNHIEPLKIQLQREPKQFPTLEFARKIESIDDFKYEDFIIK 239
V GY+ GE GD H+Y NH+ LK QL R P+ FP L+F RK+E+I+DFK+ED +
Sbjct: 458 VCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELI 517
Query: 240 DYKPHPKIEMEMAV 253
Y P+P I+MEMAV
Sbjct: 518 GYYPYPTIKMEMAV 531
>UniRef50_Q0INI0 Cluster: Os12g0446900 protein; n=11; cellular
organisms|Rep: Os12g0446900 protein - Oryza sativa
subsp. japonica (Rice)
Length = 571
Score = 274 bits (673), Expect = 1e-72
Identities = 137/250 (54%), Positives = 165/250 (66%), Gaps = 26/250 (10%)
Query: 3 RYSLHNNTLPLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLG 62
R++L N PLLT KRVF RGV+EELLW ISGST++K L KG+HIWD N SR +LD
Sbjct: 341 RFNLRRN-FPLLTTKRVFWRGVLEELLWFISGSTNAKVLQEKGIHIWDGNASRQYLD--- 396
Query: 63 FTDREEGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAW 122
+Y D DY G+G DQL VID IKNNP DRR+++ AW
Sbjct: 397 ----------------------RYTDMHADYVGKGFDQLMDVIDKIKNNPDDRRIILSAW 434
Query: 123 NSSDLKKMALPPCHCLAQFYVADGKLSCLLYQRSADMGLGVPFNIASYSLLTHMIAHVTG 182
N +DLKKMALPPCH AQFYV +G+LSC +YQRSADMGLGVPFNIASYSLLT MIA V
Sbjct: 435 NPTDLKKMALPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCD 494
Query: 183 YQAGEFIHTTGDTHVYLNHIEPLKIQLQREPKQFPTLEFARKIESIDDFKYEDFIIKDYK 242
G+F+H GD HVY H+E L+ Q++++PK FP L+ + ID F DF + Y
Sbjct: 495 LSPGDFVHVIGDAHVYRTHVEALEEQMRKQPKPFPILKINPVKKDIDSFVTSDFKLVRYD 554
Query: 243 PHPKIEMEMA 252
PH KIEM+MA
Sbjct: 555 PHHKIEMKMA 564
>UniRef50_A3QU09 Cluster: Thymidylate synthase; n=1; Oryctes
rhinoceros virus|Rep: Thymidylate synthase - Oryctes
rhinoceros virus
Length = 321
Score = 270 bits (661), Expect = 3e-71
Identities = 131/260 (50%), Positives = 173/260 (66%), Gaps = 9/260 (3%)
Query: 3 RYSLHNNTLPLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLG 62
R+ L N LPLLT K + + ++ EL W + G T+ K L + VHIW N SR +LD+ G
Sbjct: 62 RFDLRNGVLPLLTTKPMPFKTILRELFWFLRGETNQKILERQNVHIWKGNSSREYLDSRG 121
Query: 63 FTDREEGD-LGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICA 121
D E + LGP+YGFQWRH GA Y+DC TDYT +G+DQLQ VI +IK +P RR+++ A
Sbjct: 122 LYDYTEYESLGPIYGFQWRHFGASYVDCNTDYTNKGVDQLQQVIRTIKEDPTSRRIIMSA 181
Query: 122 WNSSDLKKMALPPCHCLAQFYV--ADGKLSCLLYQRSADMGLGVPFNIASYSLLTHMIAH 179
WN DL KMALPPCH L QF+V +G+LS LYQRSAD+ LGVPFNIASYS+L H+IA
Sbjct: 182 WNPVDLDKMALPPCHILVQFHVNTVNGELSAQLYQRSADLMLGVPFNIASYSILVHLIAK 241
Query: 180 VTGYQAGEFIHTTGDTHVYLNHIEPLKIQLQREPKQFPTLEF----ARKIESI-DDFKYE 234
+ G + G FIH+ GD H+Y NH+ K QL REP++ P L ++SI + +
Sbjct: 242 ICGLKPGYFIHSLGDVHIYENHVSGAKEQLTREPQRQPYLNIDIDPTLDLDSILEQLSCD 301
Query: 235 DFIIKDYKPHPK-IEMEMAV 253
F + +YK +P I++EMAV
Sbjct: 302 QFKLVNYKYNPNPIKLEMAV 321
>UniRef50_Q8WYK4 Cluster: Thymidylate synthase; n=12;
Deuterostomia|Rep: Thymidylate synthase - Homo sapiens
(Human)
Length = 230
Score = 263 bits (645), Expect = 3e-69
Identities = 116/162 (71%), Positives = 134/162 (82%)
Query: 92 DYTGQGIDQLQSVIDSIKNNPADRRMLICAWNSSDLKKMALPPCHCLAQFYVADGKLSCL 151
DY+GQG+DQLQ VID+IK NP DRR+++CAWN DL MALPPCH L QFYV + +LSC
Sbjct: 69 DYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQ 128
Query: 152 LYQRSADMGLGVPFNIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVYLNHIEPLKIQLQR 211
LYQRS DMGLGVPFNIASY+LLT+MIAH+TG + G+FIHT GD H+YLNHIEPLKIQLQR
Sbjct: 129 LYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQR 188
Query: 212 EPKQFPTLEFARKIESIDDFKYEDFIIKDYKPHPKIEMEMAV 253
EP+ FP L RK+E IDDFK EDF I+ Y PHP I+MEMAV
Sbjct: 189 EPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV 230
>UniRef50_O33380 Cluster: Thymidylate synthase; n=116; cellular
organisms|Rep: Thymidylate synthase - Neisseria
gonorrhoeae
Length = 265
Score = 243 bits (594), Expect = 4e-63
Identities = 119/242 (49%), Positives = 158/242 (65%), Gaps = 19/242 (7%)
Query: 12 PLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDL 71
PLLT K++ R +I ELLW + G T+ K L V IWD + D E GDL
Sbjct: 43 PLLTTKKLHLRSIIHELLWFLKGDTNIKYLKDNNVSIWDDE----------WAD-ENGDL 91
Query: 72 GPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWNSSDLKKMA 131
GPVYG+QWR A G+ IDQ+ +V++ IK NP RR+++ AWN + + +MA
Sbjct: 92 GPVYGYQWRSWPAP--------DGRHIDQIANVVEQIKKNPDSRRLIVSAWNPALVDEMA 143
Query: 132 LPPCHCLAQFYVADGKLSCLLYQRSADMGLGVPFNIASYSLLTHMIAHVTGYQAGEFIHT 191
LPPCH L QFYVADG LSC LYQRSAD+ LGVPFNIASY+LLT M+A V G +AGEF+HT
Sbjct: 144 LPPCHALFQFYVADGNLSCQLYQRSADIFLGVPFNIASYALLTMMMAQVCGLEAGEFVHT 203
Query: 192 TGDTHVYLNHIEPLKIQLQREPKQFPTLEFARKIESIDDFKYEDFIIKDYKPHPKIEMEM 251
GD H+Y NH E +QL+REP+ P ++ +++ + FK+EDF ++ Y PHP I+ +
Sbjct: 204 FGDAHLYRNHFEQAALQLEREPRALPVMKINPEVKDLFAFKFEDFELEGYDPHPHIKAVV 263
Query: 252 AV 253
+V
Sbjct: 264 SV 265
>UniRef50_Q8G3T9 Cluster: Thymidylate synthase; n=287; root|Rep:
Thymidylate synthase - Bifidobacterium longum
Length = 266
Score = 238 bits (582), Expect = 1e-61
Identities = 123/242 (50%), Positives = 158/242 (65%), Gaps = 17/242 (7%)
Query: 12 PLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDL 71
PLLT K VF +G+ ELLW + GS++ L VHIWD + D E GDL
Sbjct: 42 PLLTTKTVFFKGLAYELLWFLKGSSNINWLLEHNVHIWDE-----------WAD-ENGDL 89
Query: 72 GPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWNSSDLKKMA 131
GPVYG QWR A + + IDQ+ +V+D IK++P RRM++ AWN ++++KMA
Sbjct: 90 GPVYGVQWRSWPAP----TPEDPNRTIDQISNVLDLIKHHPDSRRMIVSAWNPAEVEKMA 145
Query: 132 LPPCHCLAQFYVADGKLSCLLYQRSADMGLGVPFNIASYSLLTHMIAHVTGYQAGEFIHT 191
LPPCH L QFYVAD KLSC LYQRS DM LGVPFNIASYSLLT M+A G + GEF+ T
Sbjct: 146 LPPCHALFQFYVADDKLSCQLYQRSCDMFLGVPFNIASYSLLTMMMAQQAGLKPGEFVWT 205
Query: 192 TGDTHVYLNHIEPLKIQLQREPKQFPTLEFARKIESIDDFKYEDFIIKDYKPHPKIEMEM 251
GD HVY NH++ QL R+P +PT+E RK +S+ D++YEDF + Y+ HP I+ +
Sbjct: 206 GGDCHVYDNHVDQFLEQLGRKPYPYPTIEI-RKADSLFDYQYEDFKVVGYQHHPTIKAPV 264
Query: 252 AV 253
AV
Sbjct: 265 AV 266
>UniRef50_Q5UQG3 Cluster: Bifunctional dihydrofolate
reductase-thymidylate synthase (DHFR-TS) [Includes:
Dihydrofolate reductase (EC 1.5.1.3); Thymidylate
synthase (EC 2.1.1.45)]; n=1; Acanthamoeba polyphaga
mimivirus|Rep: Bifunctional dihydrofolate
reductase-thymidylate synthase (DHFR-TS) [Includes:
Dihydrofolate reductase (EC 1.5.1.3); Thymidylate
synthase (EC 2.1.1.45)] - Mimivirus
Length = 563
Score = 228 bits (557), Expect = 1e-58
Identities = 117/252 (46%), Positives = 156/252 (61%), Gaps = 15/252 (5%)
Query: 12 PLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDL 71
P+ T KR + + + EEL+WMI G TD L KGVH+WD N S++FL EEGD+
Sbjct: 313 PIQTIKRSYPKAIFEELMWMIRGQTDVSILQKKGVHVWDKNSSKDFLSKYNLP-YEEGDI 371
Query: 72 GPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWNSSDLKKMA 131
GP YGFQ R+ GA+Y DC+T Y GQGIDQL I+SI+NNP DRR++I WN SDL KMA
Sbjct: 372 GPGYGFQMRYWGAEYTDCKTSYQGQGIDQLNKCIESIQNNPHDRRIMINLWNCSDLDKMA 431
Query: 132 LPPCHCLAQFYV----------ADGKLSCLLYQRSADMGLGVPFNIASYSLLTHMIAHVT 181
L PCH F V G+L+C L QRS D+ LG +N + +LLT++IA+
Sbjct: 432 LAPCHFCYMFGVDLYEVPTTSGKKGRLNCHLVQRSWDVLLG--WNTTTAALLTYLIANHC 489
Query: 182 GYQAGEFIHTTGDTHVYLNHIEPLKIQ--LQREPKQFPTLEFARKIESIDDFKYEDFIIK 239
G +H+ D H+Y +HI+ I LQR+ ++FP L K E IDD++++D II+
Sbjct: 490 DLDPGILVHSISDAHIYQSHIDSGAISQLLQRKCRKFPNLVIRNKKEKIDDYEFDDLIIE 549
Query: 240 DYKPHPKIEMEM 251
+Y P P I EM
Sbjct: 550 NYYPCPSISAEM 561
>UniRef50_Q81R23 Cluster: Thymidylate synthase; n=68; cellular
organisms|Rep: Thymidylate synthase - Bacillus anthracis
Length = 318
Score = 216 bits (527), Expect = 5e-55
Identities = 103/199 (51%), Positives = 133/199 (66%), Gaps = 9/199 (4%)
Query: 55 RNFLDNLGFTDREEGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPAD 114
+N L++ F+++ G LG VYG QWR G+ +DQL+ VI+ IK P
Sbjct: 129 KNVLEDDEFSNKY-GYLGDVYGKQWR--------AWKTTAGETLDQLKDVIEMIKKTPDS 179
Query: 115 RRMLICAWNSSDLKKMALPPCHCLAQFYVADGKLSCLLYQRSADMGLGVPFNIASYSLLT 174
RR+++ AWN D+ MALPPCH L QFYVADGKLSC LYQRS D+ LG+PFNIASYSLLT
Sbjct: 180 RRLIVSAWNPEDVPSMALPPCHTLFQFYVADGKLSCQLYQRSGDIFLGIPFNIASYSLLT 239
Query: 175 HMIAHVTGYQAGEFIHTTGDTHVYLNHIEPLKIQLQREPKQFPTLEFARKIESIDDFKYE 234
H+IAH G + GEF+HT GD H+Y NH E ++ QL REP+ FP L ++S+ DF+ E
Sbjct: 240 HLIAHECGLEVGEFVHTIGDAHIYTNHFEQVEKQLAREPRPFPKLTLNPDVKSVFDFEME 299
Query: 235 DFIIKDYKPHPKIEMEMAV 253
D I+ Y PHP I+ +AV
Sbjct: 300 DLTIEGYDPHPAIKAPVAV 318
Score = 39.9 bits (89), Expect = 0.060
Identities = 21/61 (34%), Positives = 34/61 (55%)
Query: 12 PLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDL 71
PLLT KRV R V ELLW + G T+ + L +IW+ ++++++ +T + D
Sbjct: 47 PLLTTKRVPFRLVASELLWFMKGDTNIRYLLQHNNNIWNEWAFKSWVESDEYTGPDMIDF 106
Query: 72 G 72
G
Sbjct: 107 G 107
>UniRef50_P78029 Cluster: Thymidylate synthase; n=20; Bacteria|Rep:
Thymidylate synthase - Mycoplasma pneumoniae
Length = 287
Score = 214 bits (523), Expect = 2e-54
Identities = 114/270 (42%), Positives = 164/270 (60%), Gaps = 34/270 (12%)
Query: 4 YSLH---NNTLPLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDA--------- 51
Y +H + PLLT K+V + ++ ELLW I G T+ K L V+IW+
Sbjct: 32 YQMHFDISKHFPLLTTKKVHWKSIVHELLWFIKGDTNIKYLVDNKVNIWNEWPYESFKKS 91
Query: 52 ---NG--SRNFLDNL---GFTDREEGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQS 103
NG + F++ + ++ G+LGPVYG QWR D+ G+DQL+
Sbjct: 92 PHFNGESQKEFIERIRQDAKFAQQFGNLGPVYGKQWR-----------DF--NGVDQLKK 138
Query: 104 VIDSIKNNPADRRMLICAWNSSDLKKMALPPCHCLAQFYVADGKLSCLLYQRSADMGLGV 163
VI IK NP RR+++ +WN +++ +M LPPCH L QFYV DG+LSC LYQRS D+ LG+
Sbjct: 139 VIAQIKVNPFSRRLIVSSWNPNEVDQMLLPPCHSLYQFYVQDGQLSCQLYQRSGDIFLGI 198
Query: 164 PFNIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVYLNHIEPLKIQLQREPKQFPTLEFAR 223
PFNIASYSLL +++A T + G F+HT GD H+Y NH+E +K+QL R+PK P + +
Sbjct: 199 PFNIASYSLLVYLVAKETNLKPGSFVHTIGDAHIYENHLEQIKLQLTRQPKPLPKV-VLK 257
Query: 224 KIESIDDFKYEDFIIKDYKPHPKIEMEMAV 253
+SI D++++D + DY HP I+ E+AV
Sbjct: 258 SDKSIFDYQFDDIELVDYDHHPTIKGEVAV 287
>UniRef50_Q9Z671 Cluster: Thymidylate synthase; n=9;
Alphaproteobacteria|Rep: Thymidylate synthase -
Zymomonas mobilis
Length = 296
Score = 213 bits (519), Expect = 5e-54
Identities = 115/270 (42%), Positives = 158/270 (58%), Gaps = 25/270 (9%)
Query: 1 MQRYSLHNNTLPLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIW-DANGSRNFLD 59
M R+ L +P+LT K+V R I E+LW +SG T+ + L +GV IW D +R +
Sbjct: 35 MMRFDLSKGRIPILTTKKVSYRLAIREMLWFLSGDTNIRPLVEQGVSIWSDWPLARYQAE 94
Query: 60 NLGFTDREE---------------GDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSV 104
++E GDLGPVYG QWR GQ DQ+ ++
Sbjct: 95 TGALLSKKEFEAKILADTEFAKKWGDLGPVYGRQWRRWQGS--------DGQVYDQIATL 146
Query: 105 IDSIKNNPADRRMLICAWNSSDLKKMALPPCHCLAQFYV-ADGKLSCLLYQRSADMGLGV 163
I+++K+NP+ RRML WN ++LK MALPPCH + Q++V +DG+L+ LLYQRSAD+ LG+
Sbjct: 147 IETLKSNPSSRRMLFHGWNVAELKDMALPPCHMVYQYHVTSDGRLNSLLYQRSADVFLGL 206
Query: 164 PFNIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVYLNHIEPLKIQLQREPKQFPTLEFAR 223
PFN+ + L M+A G G+ + T GD H+Y NHI+ +K QL REP+ FP LE R
Sbjct: 207 PFNLVGAAALQAMLADQAGLALGDLVWTGGDVHIYRNHIDQMKEQLAREPRAFPRLELTR 266
Query: 224 KIESIDDFKYEDFIIKDYKPHPKIEMEMAV 253
SI D+K EDF I Y PHP I+ +AV
Sbjct: 267 HPNSITDYKIEDFAITGYDPHPPIKGAVAV 296
>UniRef50_Q8WYK3 Cluster: Thymidylate synthase; n=4; Eutheria|Rep:
Thymidylate synthase - Homo sapiens (Human)
Length = 279
Score = 210 bits (513), Expect = 3e-53
Identities = 94/129 (72%), Positives = 106/129 (82%)
Query: 125 SDLKKMALPPCHCLAQFYVADGKLSCLLYQRSADMGLGVPFNIASYSLLTHMIAHVTGYQ 184
SDL MALPPCH L QFYV + +LSC LYQRS DMGLGVPFNIASY+LLT+MIAH+TG +
Sbjct: 151 SDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLK 210
Query: 185 AGEFIHTTGDTHVYLNHIEPLKIQLQREPKQFPTLEFARKIESIDDFKYEDFIIKDYKPH 244
G+FIHT GD H+YLNHIEPLKIQLQREP+ FP L RK+E IDDFK EDF I+ Y PH
Sbjct: 211 PGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPH 270
Query: 245 PKIEMEMAV 253
P I+MEMAV
Sbjct: 271 PTIKMEMAV 279
Score = 140 bits (338), Expect = 4e-32
Identities = 63/90 (70%), Positives = 76/90 (84%), Gaps = 1/90 (1%)
Query: 3 RYSLHNNTLPLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLG 62
RYSL + PLLT KRVF +GV+EELLW I GST++K L++KGV IWDANGSR+FLD+LG
Sbjct: 64 RYSLRDE-FPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLG 122
Query: 63 FTDREEGDLGPVYGFQWRHSGAKYIDCQTD 92
F+ REEGDLGPVYGFQWRH GA+Y D ++D
Sbjct: 123 FSTREEGDLGPVYGFQWRHFGAEYRDMESD 152
>UniRef50_Q0FG99 Cluster: Thymidylate synthase; n=3; root|Rep:
Thymidylate synthase - alpha proteobacterium HTCC2255
Length = 292
Score = 203 bits (495), Expect = 4e-51
Identities = 112/265 (42%), Positives = 154/265 (58%), Gaps = 21/265 (7%)
Query: 3 RYSLHNNTLPLLTPKRVFTRGVIEELLWMISGSTDSKALAAKG--------VH---IWDA 51
R++L P +T K++ R ++ ELLW + GSTD + LA VH IW A
Sbjct: 35 RFNLQEG-FPAVTTKKLAWRSIVGELLWFLEGSTDERRLAELTFNKDRTDLVHKKTIWTA 93
Query: 52 NGSRNFLDNLGFTDREE-GDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKN 110
N + LG+ + + +LGPVYG QWRH D DQ+ +I+ IKN
Sbjct: 94 NADAQGAE-LGYENNDLIKELGPVYGHQWRHFDGTDKDISLS-----TDQIIWLINEIKN 147
Query: 111 NPADRRMLICAWNSSDLKKMALPPCHCLAQFYVADGKLSCLLYQRSADMGLGVPFNIASY 170
NP RRM++ AWN + + +MALPPCH +AQF V +GKLSC LYQRSADM LGVPFNIASY
Sbjct: 148 NPDSRRMILSAWNPNQINEMALPPCHTMAQFRVMNGKLSCQLYQRSADMFLGVPFNIASY 207
Query: 171 SLLTHMIAHVTGYQAGEFIHTTGDTHVYLNHIEPLKIQLQREPKQFPTLEFA--RKIESI 228
SLLTHM+A + + G F+ GD H+Y NH + + QL+R PK P LE ++ +
Sbjct: 208 SLLTHMLAQLCDLKVGSFVWVGGDCHIYKNHKKQVLEQLKRTPKSLPNLEMPSFSNLDEL 267
Query: 229 DDFKYEDFIIKDYKPHPKIEMEMAV 253
+ +++K+Y P I+ MA+
Sbjct: 268 LQTRPIGYVLKNYDPMDSIKAPMAI 292
>UniRef50_Q67JQ1 Cluster: Thymidylate synthase; n=1; Symbiobacterium
thermophilum|Rep: Thymidylate synthase - Symbiobacterium
thermophilum
Length = 283
Score = 201 bits (491), Expect = 1e-50
Identities = 106/244 (43%), Positives = 146/244 (59%), Gaps = 17/244 (6%)
Query: 12 PLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDL 71
P LT K++F V ELLW ++G TD + L +G HIWD + +RN G L
Sbjct: 53 PALTTKKLFFNSVKAELLWFLAGRTDLEFLHERGCHIWDKDAARN-----------GGKL 101
Query: 72 GPVYGFQWRH-SGAKYIDCQT-DYTGQGIDQLQSVI-DSIKNNPADRRMLICAWNSSDLK 128
GP+YG QWR GA D +T D I Q++ + D + +P RR+++ WN +DL+
Sbjct: 102 GPIYGKQWRAWEGA---DGRTYDQIAWVIQQIREIAADPERPHPNSRRLVVSPWNVADLE 158
Query: 129 KMALPPCHCLAQFYVADGKLSCLLYQRSADMGLGVPFNIASYSLLTHMIAHVTGYQAGEF 188
+MALPPCH QF+V DG+L ++QRSAD+ LGVPFNIASYSLL HM+A VTG G +
Sbjct: 159 EMALPPCHGPFQFHVKDGRLHLAVWQRSADLFLGVPFNIASYSLLLHMVAQVTGLAVGTY 218
Query: 189 IHTTGDTHVYLNHIEPLKIQLQREPKQFPTLEFARKIESIDDFKYEDFIIKDYKPHPKIE 248
H D H+Y N ++ +++QL REP P L ++ ID F +D + DYK HP I
Sbjct: 219 THYLNDVHIYRNLLDQVRLQLTREPYPLPRLWLNPEVREIDQFTMDDIQLVDYKHHPPIR 278
Query: 249 MEMA 252
E++
Sbjct: 279 GELS 282
>UniRef50_Q76YC2 Cluster: DTMP synthase; n=1; Aeromonas phage
Aeh1|Rep: DTMP synthase - Aeromonas phage Aeh1
Length = 277
Score = 193 bits (470), Expect = 4e-48
Identities = 110/252 (43%), Positives = 148/252 (58%), Gaps = 27/252 (10%)
Query: 12 PLLTPKRVFTRGVIEELLWMISGSTDSKALAAK--GVH-----IWDANGSRNFLDNLGFT 64
P +T K + + V E LW ++G T+ + L A GV IWD N + + LG+T
Sbjct: 43 PAVTTKTLAWKAVRGECLWFMNGFTNVEVLRAMTYGVGSSSKTIWDDNFNHQGVA-LGYT 101
Query: 65 DREEGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWNS 124
D G+LGPVYG QWR D+ G +DQL I+ IK NP RR ++CAWN
Sbjct: 102 D---GELGPVYGKQWR-----------DFNG--VDQLAKAIERIKTNPECRRNIVCAWNP 145
Query: 125 SDLKKMALPPCHCLAQFYVADGKLSCLLYQRSADMGLGVPFNIASYSLLTHMIAHVTGYQ 184
DL KMALPPCH L +F V G+L+ YQRS D LG+PFNIASY LL ++A +TGY+
Sbjct: 146 VDLDKMALPPCHVLFRFSVKRGRLNLTWYQRSVDTFLGLPFNIASYGLLLEIVAQITGYK 205
Query: 185 AGEFIHTTGDTHVYLNHIEPLKIQLQREPKQFPTLEFARKIESIDD---FKYEDFIIKDY 241
AG DTH+Y NH E ++ QLQREP + PTL+F + ++++ +D ++DY
Sbjct: 206 AGILTGMLDDTHIYHNHFEQVQEQLQREPHKLPTLKFKNRFTTLEEACNLSVDDIELEDY 265
Query: 242 KPHPKIEMEMAV 253
K H I+ MAV
Sbjct: 266 KCHSAIKAPMAV 277
>UniRef50_Q8MVZ9 Cluster: Bifunctional dihydrofolate
reductase-thymidylate synthase; n=1; Cercomonas
longicauda|Rep: Bifunctional dihydrofolate
reductase-thymidylate synthase - Cercomonas longicauda
Length = 314
Score = 188 bits (457), Expect = 2e-46
Identities = 80/137 (58%), Positives = 103/137 (75%), Gaps = 1/137 (0%)
Query: 1 MQRYSLHNNTLPLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDN 60
M ++SL N +PLLT +++F +GV+EELLWM+ G T S+ L KGV+IW ANGSR LD
Sbjct: 178 MMKFSLENGQIPLLTIRKIFWKGVVEELLWMLRGKTHSRDLEEKGVNIWRANGSREALDR 237
Query: 61 LGFTDREEGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNP-ADRRMLI 119
LG DRE GDLGP+YG+QWRHSGA Y TDY+G G+DQ++ VI ++N P +RR+L
Sbjct: 238 LGMVDREVGDLGPIYGWQWRHSGAXYTTAHTDYSGFGVDQIKDVISQLQNQPQKNRRILF 297
Query: 120 CAWNSSDLKKMALPPCH 136
C+WN DLK+MALPPCH
Sbjct: 298 CSWNPKDLKQMALPPCH 314
>UniRef50_A5KSZ1 Cluster: Thymidylate synthase; n=1; candidate
division TM7 genomosp. GTL1|Rep: Thymidylate synthase -
candidate division TM7 genomosp. GTL1
Length = 280
Score = 184 bits (448), Expect = 2e-45
Identities = 101/252 (40%), Positives = 144/252 (57%), Gaps = 29/252 (11%)
Query: 12 PLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDL 71
PLLT K++ + ++ EL W ISGS+ L +H WD GF DL
Sbjct: 47 PLLTTKKMPFKILLHELFWFISGSSSVDYLHEHKIHYWD-----------GFLHEGSDDL 95
Query: 72 GPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWNSSDL--KK 129
G VYG QWRH + D G DQLQ I+ IK NP + +++ AWN+ +L K+
Sbjct: 96 GRVYGVQWRHW------LRPD--GSQFDQLQWAIEQIKTNPNSKAIIVSAWNAGELGDKR 147
Query: 130 --------MALPPCHCLAQFYVADGKLSCLLYQRSADMGLGVPFNIASYSLLTHMIAHVT 181
M LPPCH + QF V GKL LYQRS+D+ LG+PFNIA Y++L HM+A++
Sbjct: 148 WNPNDYGDMRLPPCHTMFQFDVTGGKLRMQLYQRSSDVFLGLPFNIAQYAMLLHMVAYLA 207
Query: 182 GYQAGEFIHTTGDTHVYLNHIEPLKIQLQREPKQFPTLEFARKIESIDDFKYEDFIIKDY 241
+ E I + G H+Y N IEP K Q++R+P +FP L A ++ IDDFK ++F ++ Y
Sbjct: 208 DLEPRELIISIGSAHLYRNQIEPAKEQVRRKPYRFPKLTIAGDVKDIDDFKEKNFSLEGY 267
Query: 242 KPHPKIEMEMAV 253
+ HP I+ ++ +
Sbjct: 268 QSHPHIKTDLVI 279
>UniRef50_P00471 Cluster: Thymidylate synthase; n=17; Viruses|Rep:
Thymidylate synthase - Bacteriophage T4
Length = 286
Score = 179 bits (435), Expect = 7e-44
Identities = 103/261 (39%), Positives = 147/261 (56%), Gaps = 36/261 (13%)
Query: 12 PLLTPKRVFTRGVIEELLWMISGSTDSKALAA-------KGVHIWDANGSRNFLDNLGFT 64
P +T K++ + I EL+W +SGST+ L +G +WD N N +LG+
Sbjct: 43 PAVTTKKLAWKACIAELIWFLSGSTNVNDLRLIQHDSLIQGKTVWDEN-YENQAKDLGY- 100
Query: 65 DREEGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWNS 124
G+LGP+YG QWR G G+DQ+ VID IK P DRR ++ AWN
Sbjct: 101 --HSGELGPIYGKQWRDFG-------------GVDQIIEVIDRIKKLPNDRRQIVSAWNP 145
Query: 125 SDLKKMALPPCHCLAQFYVADGKLSCLLYQRSADMGLGVPFNIASYSLLTHMIAHVTGYQ 184
++LK MALPPCH QF V +G L YQRS D+ LG+PFNIASY+ L H++A +
Sbjct: 146 AELKYMALPPCHMFYQFNVRNGYLDLQWYQRSVDVFLGLPFNIASYATLVHIVAKMCNLI 205
Query: 185 AGEFIHTTGDTHVYLNHIEPLKIQLQREPKQFPTLEFA------RKIESIDDFKY----- 233
G+ I + G+TH+Y+NH+E K L+REPK+ L + R + + + KY
Sbjct: 206 PGDLIFSGGNTHIYMNHVEQCKEILRREPKELCELVISGLPYKFRYLSTKEQLKYVLKLR 265
Query: 234 -EDFIIKDYKPHPKIEMEMAV 253
+DF++ +Y HP I+ +MAV
Sbjct: 266 PKDFVLNNYVSHPPIKGKMAV 286
>UniRef50_Q2S5G7 Cluster: Thymidylate synthase; n=8; Bacteria|Rep:
Thymidylate synthase - Salinibacter ruber (strain DSM
13855)
Length = 355
Score = 173 bits (420), Expect = 5e-42
Identities = 104/264 (39%), Positives = 145/264 (54%), Gaps = 34/264 (12%)
Query: 12 PLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLG-------FT 64
PLLT KRV+ RGV EELLW + G T+ ++L V IW + + D G F
Sbjct: 104 PLLTTKRVWMRGVTEELLWFLRGETNIQSLVQADVSIWTDWPLQRYRDETGDEISQEAFE 163
Query: 65 DR---------EEGDLGPVYGFQWRHSGAKYIDCQTDYTG-QG-IDQLQSVIDSIKNNPA 113
+R GDLGPVYG QWR D+ G +G +DQ++ ++ ++ P
Sbjct: 164 ERIATDDAFAERWGDLGPVYGTQWR-----------DFEGPEGRVDQIERLVRGLRETPH 212
Query: 114 DRRMLICAWNSSDLKKMALPPCHCLAQFYV----ADGKLSCLLYQRSADMGLGVPFNIAS 169
RR ++ AW+ + ++ ALPPCH Q +V DG+LS + QRS D LG+PFNIAS
Sbjct: 213 SRRHVVSAWHPAQIEDAALPPCHYAFQCFVEGEPGDGRLSLMWQQRSVDSFLGLPFNIAS 272
Query: 170 YSLLTHMIAHVTGYQAGEFIHTTGDTHVYLNHIEPLKIQLQREPKQFPTLEFARKIESID 229
Y+LLT M+A G E I GD H+Y NH+E ++ QL R P PTL R+ +SI
Sbjct: 273 YALLTRMLAQQAGLTPHELIFNGGDCHIYQNHVEQVEEQLTRTPYDRPTLRL-RQRDSIF 331
Query: 230 DFKYEDFIIKDYKPHPKIEMEMAV 253
+ +D I+DY+ HP + +AV
Sbjct: 332 EHAADDVTIEDYEHHPALTAPIAV 355
>UniRef50_P42326 Cluster: Thymidylate synthase A; n=9; root|Rep:
Thymidylate synthase A - Bacillus subtilis
Length = 279
Score = 171 bits (417), Expect = 1e-41
Identities = 98/247 (39%), Positives = 136/247 (55%), Gaps = 20/247 (8%)
Query: 8 NNTLPLLTPKRVFTRGVIEELLWMIS-GSTDSKALAAKGVHIWDANGSRNFLDNLGFTDR 66
N+ +P+LT K+V + I+ELLW+ S D L GVHIWD +
Sbjct: 52 NSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQ------------WKQ 99
Query: 67 EEGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWNSSD 126
E+G +G YGFQ G K G+ +DQ+ ++ +KNNP+ RR + WN +
Sbjct: 100 EDGTIGHAYGFQL---GKK----NRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDE 152
Query: 127 LKKMALPPCHCLAQFYVADGKLSCLLYQRSADMGLGVPFNIASYSLLTHMIAHVTGYQAG 186
L MAL PC Q+YV GKL + RS DM LG PFN+ Y++L MIA VTGY+ G
Sbjct: 153 LDAMALTPCVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELG 212
Query: 187 EFIHTTGDTHVYLNHIEPLKIQLQREPKQFPTLEFARKIESIDDFKYEDFIIKDYKPHPK 246
E+I GD HVY HI+ LKIQ++RE + P L +++ DF +DF + +YK K
Sbjct: 213 EYIFNIGDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDK 272
Query: 247 IEMEMAV 253
+ E+AV
Sbjct: 273 LLFEVAV 279
>UniRef50_Q6QGJ5 Cluster: Putative thymidylate synthase; n=1;
Enterobacteria phage T5|Rep: Putative thymidylate
synthase - Bacteriophage T5
Length = 279
Score = 170 bits (414), Expect = 3e-41
Identities = 98/250 (39%), Positives = 144/250 (57%), Gaps = 23/250 (9%)
Query: 12 PLLTPKRVFTRGVIEELLWMISGSTDSKALAA----KGVHIWDANGSRNFLDNLGFTDRE 67
P +T KR+ + V+ ELLW +SGST+ L + W + N+ D +
Sbjct: 43 PAVTTKRLAWKSVVGELLWFLSGSTNLHDLRVFTFGRDEGQWTI-WTPNYEDQAISMGYD 101
Query: 68 EGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWNSSDL 127
+G+LGPVYG QWR+ G G DQ+ +I+ +KNNP RR L+ AWN ++L
Sbjct: 102 KGNLGPVYGKQWRNFG-------------GRDQILELIEGLKNNPHGRRHLVSAWNVAEL 148
Query: 128 KKMALPPCHCLAQFYVA-DGKLSCLLYQRSADMGLGVPFNIASYSLLTHMIAHVTGYQAG 186
KMALPPCH Q YV+ DG L QRS D LG+PFNIASY+LLTH++A +TG +
Sbjct: 149 DKMALPPCHYGFQCYVSNDGYLDLKWTQRSVDCFLGLPFNIASYALLTHILAKLTGLKPR 208
Query: 187 EFIHTTGDTHVYLNHIEPLKIQLQREPKQFPTLEFARKIESIDDFKYE----DFIIKDYK 242
I + GDTH+Y +H+E ++ Q++R+P+ PTL ++ D + F ++ Y
Sbjct: 209 YLIFSGGDTHIYNDHMEQVEEQVKRKPRPLPTLVMPEFVDLYDLLENNTAAWSFHLEGYD 268
Query: 243 PHPKIEMEMA 252
PHP ++ +M+
Sbjct: 269 PHPALKAKMS 278
>UniRef50_Q97EV3 Cluster: Thymidylate synthase; n=2;
Clostridium|Rep: Thymidylate synthase - Clostridium
acetobutylicum
Length = 263
Score = 162 bits (393), Expect = 9e-39
Identities = 98/245 (40%), Positives = 137/245 (55%), Gaps = 31/245 (12%)
Query: 12 PLLTPKRVFTRGVIEELLWMISG-STDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGD 70
P+LT K V + ++ELLW+ S D + L + V IWD E+G
Sbjct: 47 PILTTKFVAFKTSVKELLWIYKDQSNDVRKLQNENVTIWDE------------WMLEDGT 94
Query: 71 LGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWNSSDLKKM 130
+G YG+Q AK+ Q+ ++ID++K +P RRMLI WN +DLK M
Sbjct: 95 IGKAYGYQV----AKF------------KQIDNLIDTLKTDPQSRRMLISLWNIADLKDM 138
Query: 131 ALPPCHCLAQFYVADGKLSCLLYQRSADMGLGVPFNIASYSLLTHMIAHVTGYQAGEFIH 190
+L PC + V +GKL+C+L QRS DM LGVPFN+ Y++L H+IA VTG + G F H
Sbjct: 139 SLTPCCYETLWDVQNGKLNCMLVQRSGDMPLGVPFNMCQYAVLVHLIAQVTGLKPGLFTH 198
Query: 191 TTGDTHVYLNHIEPLKIQLQREPKQF--PTLEFARKIESIDDFKYEDFIIKDYKPHPKIE 248
+ H+Y N IE +KIQL+R K + P L I++ DF +D + DYK H KI+
Sbjct: 199 VINNAHIYKNQIEGMKIQLKRRDKAYEAPKLWINPNIKNFYDFTADDIKLIDYKHHDKIK 258
Query: 249 MEMAV 253
ME+AV
Sbjct: 259 MEVAV 263
>UniRef50_Q7Y427 Cluster: DTMP (Thymidylate) synthase; n=1;
Enterobacteria phage RB49|Rep: DTMP (Thymidylate)
synthase - Enterobacteria phage RB49
Length = 410
Score = 156 bits (378), Expect = 6e-37
Identities = 76/158 (48%), Positives = 103/158 (65%), Gaps = 4/158 (2%)
Query: 99 DQLQSVIDSIKNNPADRRMLICAWNSSDLKKMALPPCHCLAQFYVADGKLSCLLYQRSAD 158
DQLQ+VI+ IKNNP DRR++I +WN L CH QFYV +GKLSC+ +QRS D
Sbjct: 254 DQLQNVIEQIKNNPTDRRIIIDSWNVQGTHNAVLGVCHPFVQFYVNEGKLSCMWFQRSVD 313
Query: 159 MGLGVPFNIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVYLNHIEPLKIQLQREPKQFPT 218
LG+PFN+ASY+LLTH+IA + + GE I + GDTH+Y NH + + QL R P PT
Sbjct: 314 SFLGLPFNVASYALLTHIIAKMCDLEVGELIFSGGDTHIYKNHFDQVMEQLSRVPFDKPT 373
Query: 219 LEFARKIESIDDF---KYEDFIIKDYKPHPKIEMEMAV 253
+E + +S+D+ +DF I +Y+ HP I +MAV
Sbjct: 374 IELP-EFKSLDEVLTKTPKDFKIHNYQSHPAITAQMAV 410
Score = 35.9 bits (79), Expect = 0.98
Identities = 16/30 (53%), Positives = 20/30 (66%)
Query: 12 PLLTPKRVFTRGVIEELLWMISGSTDSKAL 41
PLLT K++ T VI ELLW + GS D + L
Sbjct: 43 PLLTTKKMATASVIGELLWFMEGSLDRRRL 72
>UniRef50_Q6WIC0 Cluster: DTMP (Thymidylate) synthase; n=1; Vibrio
phage KVP40|Rep: DTMP (Thymidylate) synthase -
Bacteriophage KVP40
Length = 300
Score = 153 bits (370), Expect = 5e-36
Identities = 95/258 (36%), Positives = 142/258 (55%), Gaps = 18/258 (6%)
Query: 12 PLLTPKRVFTRGVIEELLWMISGS---TDSKA---LAAKGVHIWDAN-GSRNFLDNLGFT 64
PLLT K++ T+ + ELLW +SGS +D + L+ + IW N N
Sbjct: 44 PLLTTKKMATKAIFGELLWFLSGSGLISDLRKYTELSDEDFCIWQQNLDELNERAKKAGI 103
Query: 65 DREEGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNP---ADRRMLICA 121
R E DLG VYG WR + D + Q I QL I ++K +P A RRM++ A
Sbjct: 104 VRNEDDLGYVYGKVWRKRLSVTADKEVTEFDQ-IHQLLCDIAAVKEDPTQSAQRRMIVEA 162
Query: 122 WN-----SSDLKKMALPPCHCLAQFYVADGKLSCLLYQRSADMGLGVPFNIASYSLLTHM 176
W+ S+ +ALPPCH Q +V +GK+S QRS D LG+PFNIASY+LL H+
Sbjct: 163 WDPYFHTESNSVDVALPPCHYGFQVFVRNGKISLKWNQRSVDTFLGLPFNIASYALLVHI 222
Query: 177 IAHVTGYQAGEFIHTTGDTHVYLNHIEPLKIQLQREPKQFPTLEFAR--KIESIDDFKYE 234
+A +TG + GE I + GD H+Y +HI + QL+R P++ P ++ + + +
Sbjct: 223 LAQLTGLKVGELIFSGGDVHIYEDHIVQVLKQLRRTPRELPQIQLPEFDTLSQLLTKRAS 282
Query: 235 DFIIKDYKPHPKIEMEMA 252
DF++ DY P+P ++ +M+
Sbjct: 283 DFVVYDYDPYPALKGKMS 300
>UniRef50_Q6KGF1 Cluster: Putative thymidylate synthase; n=1;
Enterobacteria phage Felix 01|Rep: Putative thymidylate
synthase - Enterobacteria phage Felix 01
Length = 299
Score = 141 bits (341), Expect = 2e-32
Identities = 91/259 (35%), Positives = 133/259 (51%), Gaps = 25/259 (9%)
Query: 12 PLLTPKRVFTRGVIEELLWMISGSTDSKALAAK--GVH------IWDANGSRNFLDNLGF 63
PLLT K+VFTR VI E LW ++G L + G + IW + R N
Sbjct: 47 PLLTSKQVFTRQVIGEALWFLNGENKLSELRYRTWGENDGERWTIWSDDFKRWLSSNYSS 106
Query: 64 T-DREEGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAW 122
D E G +YG QWR+ + G +DQL++++ +K + DR ML+ AW
Sbjct: 107 EQDWLEDAGGRIYGVQWRNFEG--------HNGCVVDQLETLVTKMKGDITDRYMLVNAW 158
Query: 123 NSSDL--KKMALPPCHCLAQFYVA-DGKLSCLLYQRSADMGLGVPFNIASYSLLTHMIAH 179
N++D+ MAL PCH + Q Y+ +G++ YQRS D LG+PFNIASY + ++
Sbjct: 159 NAADIAANSMALAPCHVMFQIYITNEGEVDLQWYQRSVDTFLGLPFNIASYGFILEVLCK 218
Query: 180 VTGYQAGEFIHTTGDTHVYLNHIEPLKIQLQREPKQFPTLEFARKIESIDDFKY---EDF 236
+TGY I GDT +Y NH++ + + E PT E + ++ D K+ DF
Sbjct: 219 MTGYTPRYLIGVFGDTQIYQNHMKQVYELMNNEEFHAPTFEIGLPLNTLSDLKHLTASDF 278
Query: 237 I--IKDYKPHPKIEMEMAV 253
I I +YK KIE ++V
Sbjct: 279 IGGINNYKHAGKIEAPLSV 297
>UniRef50_Q7WP13 Cluster: Thymidylate synthase; n=43;
Proteobacteria|Rep: Thymidylate synthase - Bordetella
bronchiseptica (Alcaligenes bronchisepticus)
Length = 323
Score = 136 bits (330), Expect = 4e-31
Identities = 96/291 (32%), Positives = 139/291 (47%), Gaps = 42/291 (14%)
Query: 3 RYSLHNNTLPLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLG 62
R+ L P +T K++ + I E++ + + + A G +WD N + N L
Sbjct: 35 RFDLQQG-FPAVTTKKLAFKSAIGEMVGFLRATRSAAQFRALGCKVWDQNANENE-QWLA 92
Query: 63 FTDRE-EGDLGPVYGFQW----------RHSGAKYIDC---------QTDYTG------- 95
RE DLGPVYG QW R +G + D + G
Sbjct: 93 NPYREGPDDLGPVYGVQWRHWPAYKLLPRSAGGQVADALARGYRQVAEVAENGAPHVLLY 152
Query: 96 QGIDQLQSVIDSIKNNPADRRMLICAWNSSDLKKMALPPCHCLAQFYVADG--KLSCLLY 153
+ +DQL+ +D+I +P DRR+L WN + +++MALPPCH L QF G ++S LY
Sbjct: 153 KAVDQLRQCLDTIHQSPGDRRILFHGWNWAQIEEMALPPCHLLYQFLPNAGTREISLCLY 212
Query: 154 QRSADMGLGVPFNIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVYLNHIEPLKIQLQREP 213
RS D+GLG PFN+ + L H++ +TGY+ F + GD HVY NH+ L+ QL REP
Sbjct: 213 IRSNDVGLGTPFNLTEGAALLHLVGRLTGYKPRWFSYFIGDAHVYENHLPMLREQLTREP 272
Query: 214 KQFPTLEFARKIESID-DFKYE----------DFIIKDYKPHPKIEMEMAV 253
P L + +I KYE DF + Y+ H + MAV
Sbjct: 273 YPAPQLVLSDRIPDFAVTGKYEPQWLEQVEPGDFTLSGYQHHAPLTAPMAV 323
>UniRef50_Q8MVZ8 Cluster: Bifunctional dihydrofolate
reductase-thymidylate synthase; n=1; Chlamydaster
sterni|Rep: Bifunctional dihydrofolate
reductase-thymidylate synthase - Chlamydaster sterni
Length = 260
Score = 122 bits (295), Expect = 7e-27
Identities = 53/82 (64%), Positives = 64/82 (78%)
Query: 3 RYSLHNNTLPLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLG 62
R+S ++TLPLLT K+VF RGV EE+LW + G TD++ L+AK +HIWD N SR FLD G
Sbjct: 179 RFSPRDDTLPLLTTKKVFWRGVAEEMLWFMKGCTDARVLSAKKIHIWDDNASRKFLDENG 238
Query: 63 FTDREEGDLGPVYGFQWRHSGA 84
+ REEGDLGPVYGFQWRH GA
Sbjct: 239 LSHREEGDLGPVYGFQWRHFGA 260
>UniRef50_Q3F0X9 Cluster: Thymidylate synthase; n=1; Bacillus
thuringiensis serovar israelensis ATCC 35646|Rep:
Thymidylate synthase - Bacillus thuringiensis serovar
israelensis ATCC 35646
Length = 286
Score = 120 bits (289), Expect = 4e-26
Identities = 79/256 (30%), Positives = 124/256 (48%), Gaps = 15/256 (5%)
Query: 1 MQRYSLHNNTLPLLTPKRVFTRGVIEELLWMI-SGSTDSKALAAKGVHIWDANGSR-NFL 58
+ RY L + P T + + + + +E+ W+ S + + AK + W +R F
Sbjct: 43 VNRYDL-SKEFPAPTTRPLPLKTIFDEVDWIYRKRSNNVNDMRAKIWNQWAFKKTRLRFS 101
Query: 59 DNLGFTDREE-GDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRM 117
F E+ G +G YG+Q Y D Q DY V+ +K +P RR
Sbjct: 102 KTFPFVRLEKKGSIGEAYGYQVAKPIFGY-DNQMDY----------VLGELKRDPFTRRA 150
Query: 118 LICAWNSSDLKKMALPPCHCLAQFYVADGKLSCLLYQRSADMGLGVPFNIASYSLLTHMI 177
+I WN D +M LPPC QF+ K + +L QRS D FN+ Y++L HM+
Sbjct: 151 VIEMWNVDDTGRMNLPPCAHHLQFWSDGKKTNLILKQRSQDFVTANAFNVCEYAILLHMV 210
Query: 178 AHVTGYQAGEFIHTTGDTHVYLNHIEPLKIQLQREPKQFPTLEFARKIESIDDFKYEDFI 237
A G + GE +H GD H+Y H+E + ++REP PTL + F +DF
Sbjct: 211 ARHIGQEVGELLHIIGDCHIYNKHLELAEELVKREPYAAPTLWINPEKTDFYSFTADDFR 270
Query: 238 IKDYKPHPKIEMEMAV 253
+++Y HP++++E+AV
Sbjct: 271 LENYDKHPQMKIEVAV 286
>UniRef50_Q87SA0 Cluster: Thymidylate synthase; n=76;
Proteobacteria|Rep: Thymidylate synthase - Vibrio
parahaemolyticus
Length = 283
Score = 119 bits (286), Expect = 8e-26
Identities = 78/257 (30%), Positives = 129/257 (50%), Gaps = 17/257 (6%)
Query: 4 YSLHNNTLPLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRN--FLDNL 61
Y + NN PL+T ++ F + + ELL I G +++ G WDAN + N +L+N
Sbjct: 37 YDVANNQFPLVTTRKSFWKAAVAELLGYIRGYDNAEDFRKLGTKTWDANANLNDAWLNNP 96
Query: 62 GFTDREEGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICA 121
+ E D+G VYG Q R + AK G IDQL+ ++D + DR ++
Sbjct: 97 --YRKGEDDMGRVYGVQGR-AWAKP-------DGGHIDQLRKIVDDLTRGVDDRGEILNF 146
Query: 122 WNSSDLKKMALPPCHCLAQFYVADGKLSCLLYQRSADMGLGVPFNIASYSLLTHMIAHVT 181
+N + L PC F + D L QRS D+ LG+ FN+ + ++A +T
Sbjct: 147 YNPGEFHMGCLRPCMYSHHFSLLDDTLYLNSTQRSCDVPLGLNFNMVQVYVFLAIMAQIT 206
Query: 182 GYQAGEFIHTTGDTHVYLNHIEPLK-IQLQREPKQFPTLEFARKIESIDDFK----YEDF 236
G + G+ H + H+Y + +E ++ +QL+REP Q PT +I+S++D + +DF
Sbjct: 207 GKKPGQAFHKIVNAHIYEDQLELMRDVQLKREPLQAPTFHINPEIKSLEDLETWVTLDDF 266
Query: 237 IIKDYKPHPKIEMEMAV 253
++ Y+ H I +V
Sbjct: 267 WVEGYEHHDPIRYPFSV 283
>UniRef50_Q8MW00 Cluster: Bifunctional dihydrofolate
reductase-thymidylate synthase; n=1; Amastigomonas
debruynei|Rep: Bifunctional dihydrofolate
reductase-thymidylate synthase - Amastigomonas debruynei
Length = 259
Score = 118 bits (285), Expect = 1e-25
Identities = 51/73 (69%), Positives = 59/73 (80%)
Query: 12 PLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDL 71
PLLT KRVF RGV EELLW +SGST++ LAAKG+ IWD N SR +LD++G T+RE GDL
Sbjct: 187 PLLTTKRVFWRGVAEELLWFVSGSTNANELAAKGIRIWDGNSSREYLDSIGLTEREVGDL 246
Query: 72 GPVYGFQWRHSGA 84
GPVYGFQW H GA
Sbjct: 247 GPVYGFQWSHFGA 259
>UniRef50_Q3IQP2 Cluster: Thymidylate synthase; n=4;
Halobacteriaceae|Rep: Thymidylate synthase -
Natronomonas pharaonis (strain DSM 2160 / ATCC 35678)
Length = 342
Score = 115 bits (277), Expect = 1e-24
Identities = 73/198 (36%), Positives = 101/198 (51%), Gaps = 12/198 (6%)
Query: 12 PLLTPKRVFT---RGVIEELLWMISGSTDSKALAAKGVHIWDA-NGSRNFLDNL--GFTD 65
PLLT KR+ +I ELLW +SG + L + IWDA LD F
Sbjct: 43 PLLTTKRMDGYRWNSLIHELLWYLSGEEHIRTLREE-TKIWDAWADDEGHLDTAYGRFWR 101
Query: 66 REEGDLGPVY--GFQWRHSGAKYIDCQTDYTG---QGIDQLQSVIDSIKNNPADRRMLIC 120
R P G W ++ +T G Q DQL V+D+++ NP RR+++
Sbjct: 102 RFPVPDEPARLPGESWPDDSHRWTTTETTPDGTERQVFDQLAYVLDTLEENPHSRRLVVN 161
Query: 121 AWNSSDLKKMALPPCHCLAQFYVADGKLSCLLYQRSADMGLGVPFNIASYSLLTHMIAHV 180
AW+ ++ LPPCH F V +L+ L QRS D+ LGVPFN+A+YSLL H +A+
Sbjct: 162 AWHPANAAVSTLPPCHYTFVFNVQGDQLNVHLTQRSGDIALGVPFNLAAYSLLAHAVANR 221
Query: 181 TGYQAGEFIHTTGDTHVY 198
T ++ G F HT D H+Y
Sbjct: 222 TAFEVGSFGHTIVDAHIY 239
Score = 41.9 bits (94), Expect = 0.015
Identities = 20/54 (37%), Positives = 30/54 (55%), Gaps = 2/54 (3%)
Query: 199 LNHIEPLKIQLQREPKQFPTLEFARKIESIDDFKYEDFIIKDYKPHPKIEMEMA 252
L+H+ L QL R P+ P +E A + +DD +Y+D + DY P P I +A
Sbjct: 290 LDHVPGLLTQLSRSPRDRPEIEVADR--PLDDLEYDDVQLHDYDPAPGISFSVA 341
>UniRef50_Q8MVZ6 Cluster: Bifunctional dihydrofolate
reductase-thymidylate synthase; n=1; Diplonema
ambulator|Rep: Bifunctional dihydrofolate
reductase-thymidylate synthase - Diplonema ambulator
Length = 255
Score = 114 bits (275), Expect = 2e-24
Identities = 50/82 (60%), Positives = 58/82 (70%)
Query: 3 RYSLHNNTLPLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLG 62
R+SL + +PLLT KRVF +GV EEL W I G T+ K L KGVHIWD NG+R FLD+ G
Sbjct: 174 RFSLRDGVIPLLTTKRVFWKGVAEELFWFIKGCTNGKDLKDKGVHIWDGNGTRAFLDSRG 233
Query: 63 FTDREEGDLGPVYGFQWRHSGA 84
DR E DLGP+YG QW H GA
Sbjct: 234 LPDRAEDDLGPIYGLQWSHFGA 255
>UniRef50_Q8MVZ5 Cluster: Bifunctional dihydrofolate
reductase-thymidylate synthase; n=1; Tetrahymena
sp.|Rep: Bifunctional dihydrofolate
reductase-thymidylate synthase - Tetrahymena sp
Length = 311
Score = 111 bits (267), Expect = 2e-23
Identities = 49/84 (58%), Positives = 55/84 (65%)
Query: 1 MQRYSLHNNTLPLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDN 60
M R+ L + PLLT K+ F RG+ EEL W + G T LAAK VHIWDAN +R FLD
Sbjct: 228 MMRFDLSSGAFPLLTTKKTFLRGIAEELFWFLKGDTSQTRLAAKDVHIWDANATRAFLDA 287
Query: 61 LGFTDREEGDLGPVYGFQWRHSGA 84
G DR EGDLGPVYG QW H GA
Sbjct: 288 RGLPDRPEGDLGPVYGCQWSHFGA 311
>UniRef50_A5Z9U8 Cluster: Thymidylate synthase; n=9; Bacteria|Rep:
Thymidylate synthase - Eubacterium ventriosum ATCC 27560
Length = 282
Score = 106 bits (254), Expect = 6e-22
Identities = 75/254 (29%), Positives = 121/254 (47%), Gaps = 29/254 (11%)
Query: 1 MQRYSLHNNTLPLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDN 60
+ RY L P +T ++ + ++ELLW+ +++ + HIWDA
Sbjct: 46 VNRYDLKKE-FPAITLRKTGFKNCLDELLWIWQKKSNN--VHDLNSHIWDA--------- 93
Query: 61 LGFTDREEGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLIC 120
+ D E G +G YG+Q G K+ Y +DQ+ V+ +K+NP RR++
Sbjct: 94 --WAD-ETGSIGKAYGYQL---GIKH-----HYKEGDMDQVDRVLYDLKHNPYSRRIMTN 142
Query: 121 AWNSSDLKKMALPPCHCLAQFYVADGK------LSCLLYQRSADMGLGVPFNIASYSLLT 174
+N DL +M L PC F V + L+ +L QRS D+ +N+ Y+ L
Sbjct: 143 IYNHEDLHEMNLYPCAYSMTFNVTKNEETGNLVLNGILNQRSQDVLTANNWNVCQYAALI 202
Query: 175 HMIAHVTGYQAGEFIHTTGDTHVYLNHIEPLKIQLQREPKQFPTLEFARKIESIDDFKYE 234
HM A V + GEFIH D H+Y H+ ++ + RE P L +I++ DF +
Sbjct: 203 HMFAQVNDMEVGEFIHVIADAHIYDKHVPLIEELITREQHPAPKLWINPEIKNFYDFTVD 262
Query: 235 DFIIKDYKPHPKIE 248
D ++DY P+I+
Sbjct: 263 DLKLEDYVTGPQIK 276
>UniRef50_Q8SCS7 Cluster: PHIKZ235; n=1; Pseudomonas phage
phiKZ|Rep: PHIKZ235 - Pseudomonas phage phiKZ
Length = 488
Score = 103 bits (248), Expect = 3e-21
Identities = 52/108 (48%), Positives = 69/108 (63%), Gaps = 2/108 (1%)
Query: 148 LSCLLYQRSADMGLGVPFNIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVYLNHIEPLKI 207
+SC LYQRS D LG PFNI YSLLTHM+A+ A EFI T GD H+Y NH E +
Sbjct: 381 ISCQLYQRSCDTFLGKPFNITFYSLLTHMLANQMNMIAEEFIWTGGDVHIYSNHQEQTDL 440
Query: 208 QLQREPKQFPTLEFARKI--ESIDDFKYEDFIIKDYKPHPKIEMEMAV 253
QL REPK PT+ F ++ + I + +DF+I++Y+ H I ++AV
Sbjct: 441 QLTREPKVLPTIRFKQEAIGKDIREIGVDDFVIENYEYHSHIAGKVAV 488
Score = 58.8 bits (136), Expect = 1e-07
Identities = 21/48 (43%), Positives = 32/48 (66%)
Query: 98 IDQLQSVIDSIKNNPADRRMLICAWNSSDLKKMALPPCHCLAQFYVAD 145
IDQ+Q +ID ++ NP RR+++CAW + + ALPPCH QF+ +
Sbjct: 261 IDQIQDIIDQLRTNPDSRRIIVCAWAPHLIDEQALPPCHAFIQFWTRE 308
Score = 58.0 bits (134), Expect = 2e-07
Identities = 25/49 (51%), Positives = 32/49 (65%)
Query: 2 QRYSLHNNTLPLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWD 50
+RYSL NN LP++T K++ VI EL WM+SG T L A GV IW+
Sbjct: 34 ERYSLRNNRLPVVTTKKIHLASVIHELFWMLSGDTKVDYLIANGVRIWN 82
>UniRef50_Q8RGP6 Cluster: Thymidylate synthase; n=3; Fusobacterium
nucleatum|Rep: Thymidylate synthase - Fusobacterium
nucleatum subsp. nucleatum
Length = 275
Score = 98.3 bits (234), Expect = 2e-19
Identities = 75/242 (30%), Positives = 112/242 (46%), Gaps = 25/242 (10%)
Query: 13 LLTPKRVFTRGVIEELLWM-ISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDL 71
L+T + ++ I EL W+ I S + L G WD ++G +
Sbjct: 58 LITSRFAPSKAPIRELYWIWILQSNNVDVLNELGCKFWDE------------WKMQDGTI 105
Query: 72 GPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWNSSDLKKMA 131
G YG+Q + GQ QL VI+ +K NP RR++ W ++L +MA
Sbjct: 106 GKAYGYQ----------IAQETFGQK-SQLHYVINELKKNPNSRRIMTEIWIPNELSEMA 154
Query: 132 LPPCHCLAQFYVADGKLSCLLYQRSADMGLGVPFNIASYSLLTHMIAHVTGYQAGEFIHT 191
L PC L Q+ V KL + QRS D+ LG+ N+ YS+L ++A G + E I
Sbjct: 155 LTPCVHLTQWSVIGNKLYLEVRQRSCDVALGLVANVFQYSVLHKLVALECGLEPAEIIWN 214
Query: 192 TGDTHVYLNHIEPLKIQLQREPKQFPTLEFARKIESIDDFKYEDFIIKDYKPHPKIEMEM 251
+ H+Y H + L Q+ RE + P +SI DFK +D I DYK K+ E+
Sbjct: 215 IHNMHIYDRHYDKLIEQVNRETFE-PAKIKINNFKSIFDFKPDDIEIIDYKYGEKVSYEV 273
Query: 252 AV 253
A+
Sbjct: 274 AI 275
>UniRef50_Q934U8 Cluster: Putative thymidylate synthase; n=1;
Salmonella typhi|Rep: Putative thymidylate synthase -
Salmonella typhi
Length = 371
Score = 91.5 bits (217), Expect = 2e-17
Identities = 45/107 (42%), Positives = 68/107 (63%), Gaps = 3/107 (2%)
Query: 149 SCLLYQRSADMGLGVPFNIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVYLNHIEPLKIQ 208
SCL+ QRS D +G+PFNIA Y +LTH +A +TG+ AG F+H D H+Y NH+ ++
Sbjct: 266 SCLV-QRSVDTFVGMPFNIAGYGILTHFLAKITGHMAGAFVHFGFDVHLYDNHMGGVEEL 324
Query: 209 LQREP--KQFPTLEFARKIESIDDFKYEDFIIKDYKPHPKIEMEMAV 253
++REP + P + F + +DDFK+E + Y P P I++ +AV
Sbjct: 325 MKREPPKESDPVVIFPHEWAELDDFKWEGVQVCGYSPLPWIKVPVAV 371
Score = 80.6 bits (190), Expect = 3e-14
Identities = 57/159 (35%), Positives = 82/159 (51%), Gaps = 38/159 (23%)
Query: 4 YSLHNNTLPLLTPKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGF 63
Y L ++PL++ K V + ++ EL W + G+ + + L GV IWDA +
Sbjct: 55 YMLTGGSVPLISGKAVNLKPLLVELEWYLKGTGNIQFLKDNGVKIWDA-----------W 103
Query: 64 TDREEGDLGPVYGFQWRH-------SGAKY---IDC--QTDYTGQG-------------- 97
D E GDLGPVYG QWR S ++Y ID + Y +G
Sbjct: 104 AD-ENGDLGPVYGKQWRRWEDTRIVSHSEYLSKIDTFRERGYKVEGYLGVSEDRVVLSRE 162
Query: 98 IDQLQSVIDSIKNNPADRRMLICAWNSSDLKKMALPPCH 136
IDQLQ ++ +++ NP DRR+L+ AWN +L+ M LPPCH
Sbjct: 163 IDQLQRIVHTLRTNPTDRRILLNAWNVGELEDMKLPPCH 201
>UniRef50_A2SMX7 Cluster: Putative thymidylate synthase; n=1;
Methylibium petroleiphilum PM1|Rep: Putative thymidylate
synthase - Methylibium petroleiphilum (strain PM1)
Length = 316
Score = 87.8 bits (208), Expect = 2e-16
Identities = 55/167 (32%), Positives = 87/167 (52%), Gaps = 13/167 (7%)
Query: 96 QGIDQLQSVIDSIKNNPADRRMLICAWNSSDLKKMALPPCHC--LAQFYVADGKLSCLLY 153
+ I+QL++ + ++ NP+DR +++ WN +++ + AL CH + Q VA G L L+
Sbjct: 150 RSINQLETSLHAVMTNPSDRGIILSGWNPAEIDQGALRSCHVSYMLQVDVATGTLHLTLW 209
Query: 154 QRSADMGLGVPFNIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVYLNHIEPLKIQLQRE- 212
QRS D L +N+A ++ ++A + G +AG F H D H+Y HI +K L RE
Sbjct: 210 QRSFDAPLA--YNVAIGAMYLEIMARLAGLKAGTFTHFISDAHIYAKHIPGVKEMLAREH 267
Query: 213 -PK------QFPTLEFARKIESI-DDFKYEDFIIKDYKPHPKIEMEM 251
P+ PTL A +I I + +Y+ HPKI EM
Sbjct: 268 FPQPTLDLGNIPTLTSAAEIPGIFATLDPNQVKLVNYQHHPKIAFEM 314
>UniRef50_Q8DUI4 Cluster: Thymidylate synthase; n=45;
Streptococcaceae|Rep: Thymidylate synthase -
Streptococcus mutans
Length = 279
Score = 68.9 bits (161), Expect = 1e-10
Identities = 50/164 (30%), Positives = 78/164 (47%), Gaps = 10/164 (6%)
Query: 99 DQLQSVIDSIKNNPADRRMLICAWNSSDLKKM-ALPPCHCLAQFYVADGK----LSCLLY 153
D + ++ ++ NP +RR +I W+ +K L PC F V K L L
Sbjct: 117 DIMNKILKQLEENPWNRRNVISLWDYEAFEKTEGLLPCAFQIMFDVRRVKGEIYLDATLT 176
Query: 154 QRSADMGLGVPFNIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVYLNHIEPLKIQLQREP 213
QRS DM + N Y L MIA G++ G+F + + H+Y N E + L+REP
Sbjct: 177 QRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFVNNLHIYDNQFEQAEELLRREP 236
Query: 214 ---KQFPTLEFARKIESIDDFKYEDFIIKDYKP-HPKIEMEMAV 253
+ L K + D K EDF + DY+P P+++ ++A+
Sbjct: 237 VVCQPHLVLNVPNK-TNFFDIKPEDFELLDYEPVKPQLKFDLAI 279
>UniRef50_A0ITX4 Cluster: Thymidylate synthase; n=1; Serratia
proteamaculans 568|Rep: Thymidylate synthase - Serratia
proteamaculans 568
Length = 325
Score = 64.5 bits (150), Expect = 2e-09
Identities = 39/140 (27%), Positives = 70/140 (50%), Gaps = 8/140 (5%)
Query: 99 DQLQSVIDSIKNNPADRRMLICAWNSSDL-------KKMALPPCHCLAQFYVADGKLSCL 151
+QL++VI ++ RR LI +++SDL + A PC QF V L
Sbjct: 114 NQLENVISLLQEKRTTRRALIQLFDASDLVTDNPEQTEYADIPCTISLQFIVRQDALHLF 173
Query: 152 LYQRSADMGLGVPFNIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVYLNHIEPLK-IQLQ 210
+ RS D +G+P ++ ++++L ++A +TG + G + H H+Y H E +K +Q +
Sbjct: 174 VCMRSNDAFMGLPHDVFAFTMLQELVARLTGCKLGHYHHFVSSLHIYEEHFEQVKALQQE 233
Query: 211 REPKQFPTLEFARKIESIDD 230
P + +I+S+ D
Sbjct: 234 GFMSTLPVMGDMPEIQSLKD 253
>UniRef50_Q2FCV1 Cluster: Thymidylate synthase; n=1; Acinetobacter
baumannii|Rep: Thymidylate synthase - Acinetobacter
baumannii
Length = 222
Score = 63.3 bits (147), Expect = 6e-09
Identities = 46/170 (27%), Positives = 75/170 (44%), Gaps = 12/170 (7%)
Query: 36 TDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDLGPVYGFQWRHSGAKYIDCQTDYTG 95
T SK ++ G W NGS D+L F + D +Q + G
Sbjct: 55 TRSKLISCIGEFFWYLNGS----DSLEFIEYYISDYRKYIEYQIDENKPALGAYGPRIFG 110
Query: 96 QGIDQLQSVIDSIKNNPADRRMLICAWNSSDLKKMALP--PCHCLAQFYVADGKLSCLLY 153
+Q +I+ +K+ P RR +I ++ DL + PC CL QF++ + +L
Sbjct: 111 AQ-NQFNKIIEVLKDKPTSRRAVISIYSKDDLLREDSRDIPCTCLLQFFIRNERLHLTAT 169
Query: 154 QRSADMGLGVPFNIASYS-----LLTHMIAHVTGYQAGEFIHTTGDTHVY 198
RS D +G+ +I S++ LL +I ++ Q GE+ H G H+Y
Sbjct: 170 MRSNDAAIGLVHDIFSFTLIQELLLAKLIRYIPNLQLGEYTHIVGSLHIY 219
>UniRef50_A3RUA7 Cluster: Deoxyuridylate hydroxymethyltransferase;
n=2; Burkholderiaceae|Rep: Deoxyuridylate
hydroxymethyltransferase - Ralstonia solanacearum UW551
Length = 352
Score = 62.9 bits (146), Expect = 7e-09
Identities = 33/108 (30%), Positives = 59/108 (54%), Gaps = 5/108 (4%)
Query: 96 QGIDQLQSVIDSIKNNPADRRMLICAWNSSDLK-KMALP----PCHCLAQFYVADGKLSC 150
+G++Q+ +VI+ + N RR +I +N+ DL +A+ PC C QF + +L
Sbjct: 108 RGVNQVSNVIEKLSGNNDTRRAVIQLFNAEDLGCDVAVGRKDIPCTCTMQFSLRARQLHM 167
Query: 151 LLYQRSADMGLGVPFNIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVY 198
+ RS D LG+P +I ++++L ++A G + G + H G H+Y
Sbjct: 168 FVTMRSNDAYLGLPHDIFAFTMLQEIVARAVGAELGTYKHAVGSLHLY 215
>UniRef50_Q1YFG6 Cluster: Possible thymidylate synthase; n=1;
Aurantimonas sp. SI85-9A1|Rep: Possible thymidylate
synthase - Aurantimonas sp. SI85-9A1
Length = 338
Score = 57.2 bits (132), Expect = 4e-07
Identities = 40/172 (23%), Positives = 76/172 (44%), Gaps = 8/172 (4%)
Query: 39 KALAAKGVHIWDANGSRNFLDNLGFTDREEGDLGPVYGFQWRHSGAKYIDCQTDYTGQGI 98
K +A G +W +GS + E D V G G +++ + + I
Sbjct: 63 KPFSALGELLWYLSGSNKLTFIKPYVSEYENDA--VDGVLEGAYGPRFLAMRGE-----I 115
Query: 99 DQLQSVIDSIKNNPADRRMLICAWNSSDLKKMALP-PCHCLAQFYVADGKLSCLLYQRSA 157
DQ S+ ++ P RR ++ +N+ D+ PC QF++ +G+L + RS
Sbjct: 116 DQFDSIERLLRRKPGSRRAVVQLFNAEDIATDHKEIPCTTTLQFHLREGRLHLSVTLRSN 175
Query: 158 DMGLGVPFNIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVYLNHIEPLKIQL 209
D G+P ++ ++++ M+A + GE+ G HVY ++ ++ L
Sbjct: 176 DAYWGLPHDVFCFTMIQEMMARRLEAELGEYYQYVGSMHVYDKYLPDMRAYL 227
>UniRef50_A7TUR1 Cluster: Putative thymidylate synthase; n=1;
Streptomyces lividans|Rep: Putative thymidylate synthase
- Streptomyces lividans
Length = 308
Score = 55.6 bits (128), Expect = 1e-06
Identities = 31/110 (28%), Positives = 56/110 (50%), Gaps = 1/110 (0%)
Query: 95 GQGIDQLQSVIDSIKNNPADRRMLICAWN-SSDLKKMALPPCHCLAQFYVADGKLSCLLY 153
G +DQL V++ ++ + RR LI ++ + D PC +F++ G+L
Sbjct: 100 GGKVDQLARVVEILQADSDSRRALIQLYDPAQDAAGHKDVPCTLGFRFHLRAGRLHMATM 159
Query: 154 QRSADMGLGVPFNIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVYLNHIE 203
R D+ +G+P+++ Y++L ++A + GEF G H+Y HIE
Sbjct: 160 MRGQDVWIGMPYDVFFYTVLHELVAGWLDAELGEFHLHIGSLHIYDEHIE 209
>UniRef50_Q8THH4 Cluster: Thymidylate synthase; n=6;
Methanosarcinales|Rep: Thymidylate synthase -
Methanosarcina acetivorans
Length = 217
Score = 54.0 bits (124), Expect = 3e-06
Identities = 30/101 (29%), Positives = 44/101 (43%)
Query: 98 IDQLQSVIDSIKNNPADRRMLICAWNSSDLKKMALPPCHCLAQFYVADGKLSCLLYQRSA 157
+DQ++ VI+ ++ +P RR W K+ PC L F + DGK+ RS
Sbjct: 102 VDQIEYVIEKLQESPTSRRATAVTWIPPVDTKVNEVPCMILDDFKIRDGKVHLTTLFRSH 161
Query: 158 DMGLGVPFNIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVY 198
D G P N+ S L +A G + G + HVY
Sbjct: 162 DFGGAYPANLYGLSKLLEYVAGRVGVEPGMITTVSISAHVY 202
>UniRef50_Q21ZJ9 Cluster: Thymidylate synthase; n=1; Rhodoferax
ferrireducens T118|Rep: Thymidylate synthase -
Rhodoferax ferrireducens (strain DSM 15236 / ATCC
BAA-621 / T118)
Length = 347
Score = 52.8 bits (121), Expect = 8e-06
Identities = 34/109 (31%), Positives = 50/109 (45%), Gaps = 7/109 (6%)
Query: 97 GIDQLQSVIDSIKNNPADRRMLICAWNS------SDLKKMALP-PCHCLAQFYVADGKLS 149
G+DQ++ V + NP R+ ++ W+S SD L PC+ + V KL
Sbjct: 113 GLDQIERVYQILSANPESRQAVLQIWDSREDLPLSDGASRDLDIPCNLVGMLKVRAQKLE 172
Query: 150 CLLYQRSADMGLGVPFNIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVY 198
L RS D+ LG P N+ ++ L +IA G G F T H+Y
Sbjct: 173 WLQIMRSNDVFLGTPHNLVQFTSLQEIIAGWLGIGIGSFSLVTDSLHLY 221
>UniRef50_P31654 Cluster: Deoxyuridylate hydroxymethyltransferase;
n=1; Bacillus phage SPO1|Rep: Deoxyuridylate
hydroxymethyltransferase - Bacteriophage SP01
Length = 383
Score = 52.4 bits (120), Expect = 1e-05
Identities = 33/110 (30%), Positives = 54/110 (49%), Gaps = 10/110 (9%)
Query: 98 IDQLQSVIDSIKNNPADRRMLICAWN------SSDLKKMALPPCHCLAQFYVADGKLSCL 151
+DQL+ V + IK +P R+ + +N ++D K PC+ L F + +GKL
Sbjct: 122 LDQLRDVYEKIKADPDTRQAVAVIYNPLFDNINNDTKDR---PCNLLLSFKLRNGKLDLS 178
Query: 152 LYQRSADMGLGV-PFNIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVYLN 200
+Y RS D+ G N+ +S + +A G + G + T HVYL+
Sbjct: 179 VYNRSNDLHWGTFGANLCQFSTILEAMATWLGVEVGSYYQITDSLHVYLD 228
>UniRef50_O28232 Cluster: Thymidylate synthase, putative; n=1;
Archaeoglobus fulgidus|Rep: Thymidylate synthase,
putative - Archaeoglobus fulgidus
Length = 480
Score = 48.8 bits (111), Expect = 1e-04
Identities = 32/119 (26%), Positives = 54/119 (45%), Gaps = 1/119 (0%)
Query: 98 IDQLQSVIDSIKNNPADRRMLICAWNSSDLKKMALPPCHCLAQFYVADGKLSCLLYQRSA 157
+DQL VI+ +K + R + DL PPC QF +L Y RS
Sbjct: 355 VDQLYKVIEKLKEDSCRRDCYVGISRPWDLLSDE-PPCLRGYQFSKYGDELLGTFYMRSN 413
Query: 158 DMGLGVPFNIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVYLNHIEPLKIQLQREPKQF 216
D + N+ +++LLT +A +TG+++ + H D H+Y + ++ L E +
Sbjct: 414 DAYGAMHANMYAFALLTKYVAELTGFKSYRYNHFALDAHIYAEFFDAVREILYPESPSY 472
>UniRef50_UPI00015972C9 Cluster: hypothetical protein RBAM_005690;
n=1; Bacillus amyloliquefaciens FZB42|Rep: hypothetical
protein RBAM_005690 - Bacillus amyloliquefaciens FZB42
Length = 336
Score = 48.0 bits (109), Expect = 2e-04
Identities = 50/216 (23%), Positives = 95/216 (43%), Gaps = 17/216 (7%)
Query: 48 IWDANGSRNFLDNLGFTDREEGDLGPVYGFQWRH-SGAKYIDCQTDYTGQGIDQLQSVID 106
+W +GS N LD + + +++ P Y + +G Y ++ ++Q + +
Sbjct: 67 LWYLSGS-NDLDFISYYNKKM----PSYSMNKKTLTGTAYGPKIFEFGNAKLNQWNRIKN 121
Query: 107 SIKNNPAD-RRMLICAWNSSDLKKMALPPCHCLA--QFYVADGKLSCLLYQRSADMGLGV 163
+ D +R I +++S+L + C QF+V +G+L R+ D G+
Sbjct: 122 LLTQEDIDSKRAFIQIFDASELFVLENIDVSCTIGLQFFVREGELYMSSVMRANDAFRGM 181
Query: 164 PFNIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVYLNHIEPLKIQLQREPK--QFPTLEF 221
++ S++ + ++A + GE+ H G H+Y + E K L+ P EF
Sbjct: 182 ISDLFSFTFMQELMARELRLEVGEYFHNAGSIHIYDSDHEWAKTVLEEAENHHDIPEFEF 241
Query: 222 ARKIE-----SIDD-FKYEDFIIKDYKPHPKIEMEM 251
+ E SI+ KYE+ + KD K ++EM
Sbjct: 242 PKMPEGNNWPSIETVLKYEELLRKDQISMTKNDIEM 277
>UniRef50_O26868 Cluster: Thymidylate synthase; n=3;
Methanothermobacter|Rep: Thymidylate synthase -
Methanobacterium thermoautotrophicum
Length = 222
Score = 46.4 bits (105), Expect = 7e-04
Identities = 30/103 (29%), Positives = 43/103 (41%), Gaps = 2/103 (1%)
Query: 97 GIDQLQSVIDSIKNNPADRRMLICAWNSSDLKKMALPPCHCLAQFYVADGKLSCLLYQRS 156
G+DQL I +KN RR + W+ + PC L F + DG+L RS
Sbjct: 108 GVDQLDEAIRRLKNCTESRRATMVTWDPPEDTASDEVPCMILVDFKIRDGRLFTTALWRS 167
Query: 157 ADM-GLGVPFNIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVY 198
D+ G P + L H+ A V G + G + H+Y
Sbjct: 168 HDIYGAWFPNAVGLAYLADHVAAEV-GVEVGHITIHSISAHIY 209
>UniRef50_A5FR57 Cluster: Thymidylate synthase-like protein; n=3;
Dehalococcoides|Rep: Thymidylate synthase-like protein -
Dehalococcoides sp. BAV1
Length = 217
Score = 45.2 bits (102), Expect = 0.002
Identities = 31/108 (28%), Positives = 48/108 (44%), Gaps = 2/108 (1%)
Query: 93 YT-GQGID-QLQSVIDSIKNNPADRRMLICAWNSSDLKKMALPPCHCLAQFYVADGKLSC 150
YT GQ ++ Q+ VI + + + + + PPC V GKL
Sbjct: 94 YTYGQYLEAQIAKVIKMYRETGFNTNQAFMTVGNPETLDLEDPPCLRSIDTRVRYGKLHF 153
Query: 151 LLYQRSADMGLGVPFNIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVY 198
++Y RS D+ G P N+A+ LL +A G + GE I + H+Y
Sbjct: 154 IIYFRSWDLWAGFPSNLAAIQLLKEYMAAEIGVEDGEIIAMSKGMHIY 201
>UniRef50_Q57931 Cluster: Thymidylate synthase; n=6;
Methanococcales|Rep: Thymidylate synthase -
Methanococcus jannaschii
Length = 222
Score = 44.4 bits (100), Expect = 0.003
Identities = 30/113 (26%), Positives = 47/113 (41%), Gaps = 5/113 (4%)
Query: 93 YTGQGIDQLQSVIDSIKNNPADRRMLICAWNSS-DLK----KMALPPCHCLAQFYVADGK 147
Y + I+Q+ +I+ + RR + WN D++ + PC L QF + +GK
Sbjct: 92 YADEKINQIDYIIEKLNQQKNSRRAVAITWNPKIDIEVSRDERGSVPCLQLVQFLIRNGK 151
Query: 148 LSCLLYQRSADMGLGVPFNIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVYLN 200
L + RS D L N L IA G G + H H+Y++
Sbjct: 152 LYQTVIFRSNDALLAFVSNAIGLITLGEYIAKKVGVGYGTYTHHAISMHIYVD 204
>UniRef50_A3CSY2 Cluster: Thymidylate synthase; n=3;
Methanomicrobiales|Rep: Thymidylate synthase -
Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498
/ JR1)
Length = 241
Score = 44.0 bits (99), Expect = 0.004
Identities = 31/111 (27%), Positives = 47/111 (42%), Gaps = 4/111 (3%)
Query: 98 IDQLQSVIDSIKNNPADRRMLICAWNSSDLKKMALPPCHCLAQFYVADGKLSCLLYQRSA 157
+DQ+ + ++ RR + WN + + PC L Q + +GKL + RS
Sbjct: 104 VDQIDYIARKLEQAANSRRAVAVTWNPVVDENLDDCPCLQLVQCLLRNGKLQMKVVFRSN 163
Query: 158 DMGLGVPFNIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVY----LNHIEP 204
D+ N+ + L MIA G G + H H+Y LN IEP
Sbjct: 164 DILSAAGSNMYALVRLQKMIADRLGVPCGRYTHIALVPHIYYRRDLNDIEP 214
>UniRef50_Q5DN81 Cluster: Thymidylate synthase; n=2; unclassified
Siphoviridae|Rep: Thymidylate synthase - Phage phiJL001
Length = 350
Score = 43.2 bits (97), Expect = 0.006
Identities = 28/107 (26%), Positives = 49/107 (45%), Gaps = 7/107 (6%)
Query: 99 DQLQSVIDSIKNNPADRRMLICAWNSS-DLKKMAL----PPCHCLAQFYVAD-GKLSCLL 152
DQL + ++ P DRR+++ W + D ++ PC+ F + D G+L +
Sbjct: 114 DQLSWAVHRLRRLPNDRRVVVQMWAAGLDQERADAGGKDVPCNIAIHFRINDRGQLDMTV 173
Query: 153 YQRSADMGLGV-PFNIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVY 198
+ RS D+ G N+ S+L +A G + G + + D H Y
Sbjct: 174 WNRSNDIIWGAYGANVVHMSILQEYVASAVGVEVGRYWQVSDDYHAY 220
>UniRef50_Q2T5Q0 Cluster: Deoxyuridylate hydroxymethyltransferase ,
putative; n=7; pseudomallei group|Rep: Deoxyuridylate
hydroxymethyltransferase , putative - Burkholderia
thailandensis (strain E264 / ATCC 700388 / DSM 13276
/CIP 106301)
Length = 329
Score = 42.7 bits (96), Expect = 0.009
Identities = 23/109 (21%), Positives = 52/109 (47%), Gaps = 3/109 (2%)
Query: 93 YTGQGIDQLQSVIDSIKNNPADRRMLICAWNSSD---LKKMALPPCHCLAQFYVADGKLS 149
Y + +DQ++ +D + + A+ + ++ S+D ++ C Q + +G+L
Sbjct: 109 YGARALDQIERALDILSRDDAESKRVVLQIFSADEDLYRRNIDVSCTLGLQLLLREGRLH 168
Query: 150 CLLYQRSADMGLGVPFNIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVY 198
+ + R+ D +G+ ++ S++ L +A + G + H G HVY
Sbjct: 169 MVAFMRANDAYVGLLNDVFSFTFLQEYVATRLDCEIGAYSHHVGSIHVY 217
>UniRef50_A1IF84 Cluster: Thymidylate synthase; n=1; Candidatus
Desulfococcus oleovorans Hxd3|Rep: Thymidylate synthase
- Candidatus Desulfococcus oleovorans Hxd3
Length = 263
Score = 41.9 bits (94), Expect = 0.015
Identities = 31/102 (30%), Positives = 49/102 (48%), Gaps = 2/102 (1%)
Query: 98 IDQLQSVIDSIKNNPA-DRRMLICAWNSSDLKKMALPPCHCLAQFYVADGKLSCLLYQRS 156
I+Q++ VID+ K A + +M++ SDL + PPC + D +L +Y RS
Sbjct: 149 INQIEWVIDTYKRFGARNNQMVLQVAEPSDLALLD-PPCLRSIDTRIQDDQLIFFVYFRS 207
Query: 157 ADMGLGVPFNIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVY 198
D+ G+P N+A L +A G G I + H+Y
Sbjct: 208 WDLWGGLPANLAGIQNLKEYMAGEIGVADGPMIVESKGLHLY 249
>UniRef50_A7FS25 Cluster: Thymidylate synthase; n=4; Clostridium
botulinum|Rep: Thymidylate synthase - Clostridium
botulinum (strain ATCC 19397 / Type A)
Length = 324
Score = 40.7 bits (91), Expect = 0.035
Identities = 24/104 (23%), Positives = 50/104 (48%), Gaps = 4/104 (3%)
Query: 98 IDQLQSVIDSIKNNPADRRMLICAWNSSD---LKKMALPPCHCLAQFYVADGKLSCLLYQ 154
I+Q +I K +P +R I +++++ LK + + C QF++ + KL +
Sbjct: 113 INQWNRIIKLFKEDPDTKRGFIEIFDANEDLSLKNIDVS-CTIGFQFFIREHKLYMTTFM 171
Query: 155 RSADMGLGVPFNIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVY 198
R+ D G+ ++ S++ + +A G++ H TH+Y
Sbjct: 172 RANDAYRGIISDVFSFTFIQEFLATELNLDIGQYSHQVATTHIY 215
>UniRef50_A5KRW4 Cluster: Thymidylate synthase-like protein; n=1;
candidate division TM7 genomosp. GTL1|Rep: Thymidylate
synthase-like protein - candidate division TM7 genomosp.
GTL1
Length = 208
Score = 39.9 bits (89), Expect = 0.060
Identities = 22/108 (20%), Positives = 46/108 (42%)
Query: 100 QLQSVIDSIKNNPADRRMLICAWNSSDLKKMALPPCHCLAQFYVADGKLSCLLYQRSADM 159
Q++ +I + I W+ + + + PC + + GKL ++ S+D+
Sbjct: 96 QIEFLISKLDPQSPKGEAQISMWDKNIDQDQKVSPCTQIIWARIKHGKLELHVHAHSSDV 155
Query: 160 GLGVPFNIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVYLNHIEPLKI 207
+ NI + L H IA G G++ H H++ I+ +++
Sbjct: 156 YKKLLMNILEFVSLQHYIAERVGVPVGKYYHFLDSGHLHQKDIKAIEV 203
>UniRef50_Q4C4J0 Cluster: Thymidylate synthase; n=1; Crocosphaera
watsonii WH 8501|Rep: Thymidylate synthase -
Crocosphaera watsonii
Length = 502
Score = 39.5 bits (88), Expect = 0.080
Identities = 28/106 (26%), Positives = 45/106 (42%), Gaps = 6/106 (5%)
Query: 99 DQLQSVIDSIKNNPADRRMLICAWNSSDLKKMALPPCHCLAQFYVADGKLSCLLYQRSAD 158
DQ++ ID + ++ R+++ W+ D + PPC + D +LS RS D
Sbjct: 288 DQIKQAIDKLISDKDSSRVVMSLWDVKDYENNDSPPCLNHIWVRIVDDELSLTATFRSND 347
Query: 159 MGLGVPFN-IASYSLLTHMIAHVT-----GYQAGEFIHTTGDTHVY 198
M P N + L H+I V +Q G I + H+Y
Sbjct: 348 MFSAWPANAMGLRELQQHIIEEVNNKYQHNFQLGPLIIISQSAHIY 393
>UniRef50_Q52PP0 Cluster: Putative thymidylate synthase; n=1;
Xanthomonas phage Xp15|Rep: Putative thymidylate
synthase - Xanthomonas phage Xp15
Length = 273
Score = 39.1 bits (87), Expect = 0.11
Identities = 27/113 (23%), Positives = 52/113 (46%), Gaps = 7/113 (6%)
Query: 95 GQGIDQLQSVIDSIKNNPADRRMLICAWNSSDLKKMALPP-CHCLAQFYVADGKLSCLLY 153
GQ + ++ V++ I++ + RR +I L + C F++ L ++
Sbjct: 105 GQQMGVMKVVMELIRDQDS-RRAIIPMLTDDHLSPETVDTVCTEAVSFHIRHNTLYTSVH 163
Query: 154 QRSADMGLGVPFNIASYSLLTHMI-----AHVTGYQAGEFIHTTGDTHVYLNH 201
RS+D G+ +I ++S+LTH++ A+ Q G T +H+Y H
Sbjct: 164 MRSSDQIFGLGTDIPTFSVLTHLVHGLLQANYPSLQVGSMTITAASSHIYERH 216
>UniRef50_Q2NEY9 Cluster: ThyA; n=1; Methanosphaera stadtmanae DSM
3091|Rep: ThyA - Methanosphaera stadtmanae (strain DSM
3091)
Length = 209
Score = 36.7 bits (81), Expect = 0.56
Identities = 26/102 (25%), Positives = 43/102 (42%), Gaps = 2/102 (1%)
Query: 98 IDQLQSVIDSIKNNPADRRMLICAWNSSDLKKMALPPCHCLAQFYVADGKLSCLLYQRSA 157
IDQ+ + I+ + N P RR + + K+ PC F + D +L + RS
Sbjct: 95 IDQIDTCIEKLNNCPQSRRAIAITIDPIQDNKVDEIPCLQEIAFLIRDNQLYMTDFFRSN 154
Query: 158 DMGLGVPF-NIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVY 198
D G G F N+ + + +A T + +H H+Y
Sbjct: 155 DCG-GATFPNLFGIREVGYYVAKNTDTELVNMVHHAMSLHIY 195
>UniRef50_Q5QC34 Cluster: RB69 orf048c-like; n=3; Viruses|Rep: RB69
orf048c-like - Enterobacteria phage JS98
Length = 160
Score = 34.3 bits (75), Expect = 3.0
Identities = 25/113 (22%), Positives = 44/113 (38%), Gaps = 5/113 (4%)
Query: 91 TDYTGQGIDQLQSVIDSIKNNPADRRMLICAWNSSDLKKMALP-----PCHCLAQFYVAD 145
T Y + + QL +++ +K RR++ D + PC +Y+ D
Sbjct: 36 TFYGPRIVAQLPALLKELKEKANSRRVVFQILQEQDQALLDSDESLEYPCTDSVTYYIRD 95
Query: 146 GKLSCLLYQRSADMGLGVPFNIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVY 198
G+L + RS + + + + L IA G G + HT HV+
Sbjct: 96 GRLYAHTHMRSQNCAVVMQLDFYLQGKLMAFIAEQCGVGLGTYSHTMVSAHVF 148
>UniRef50_Q6IIS4 Cluster: HDC17231; n=1; Drosophila
melanogaster|Rep: HDC17231 - Drosophila melanogaster
(Fruit fly)
Length = 93
Score = 34.3 bits (75), Expect = 3.0
Identities = 18/45 (40%), Positives = 26/45 (57%), Gaps = 6/45 (13%)
Query: 44 KGVHIWDANGSRNFLD-NLGFTDREEGDLGPVYGFQWRHSGAKYI 87
KG H+W N +R F+ LGF D+ + P +GF W SG +Y+
Sbjct: 8 KGSHVWKDNATRMFIKFTLGFIDQ----IRPDFGFLWL-SGMRYV 47
>UniRef50_Q0KHA0 Cluster: Embryonic ectoderm development protein;
n=1; Suberites domuncula|Rep: Embryonic ectoderm
development protein - Suberites domuncula (Sponge)
Length = 344
Score = 34.3 bits (75), Expect = 3.0
Identities = 28/101 (27%), Positives = 45/101 (44%), Gaps = 10/101 (9%)
Query: 50 DANGSRNFLDNLGFTDREEGD----LGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVI 105
DA+ NF D E G+ +G + G R G +C+ Y+G G + I
Sbjct: 49 DADSEENFYTCAWSYDTETGEGLLAIGGLKGIV-RVIGTSTANCKASYSGHG-----NAI 102
Query: 106 DSIKNNPADRRMLICAWNSSDLKKMALPPCHCLAQFYVADG 146
+ +K +P+D R+L+ A L+ L C+A A+G
Sbjct: 103 NELKVHPSDPRLLLSASKDHALRLWNLKTSVCIAVLGGAEG 143
>UniRef50_Q5KLQ8 Cluster: Cell growth and/or maintenance-related
protein, putative; n=2; Filobasidiella neoformans|Rep:
Cell growth and/or maintenance-related protein, putative
- Cryptococcus neoformans (Filobasidiella neoformans)
Length = 488
Score = 34.3 bits (75), Expect = 3.0
Identities = 26/105 (24%), Positives = 44/105 (41%), Gaps = 15/105 (14%)
Query: 33 SGSTDSKALAAKGVHIW-DANGSRNFLDNLGFTDREEGDLGP------VYGFQWRHSGAK 85
S ++ + K H+W D NGS D LG + GD G V G +W+ G
Sbjct: 191 SANSSGRPSPTKAQHVWNDLNGS----DGLGCII-DGGDCGVGVESTVVNGLEWKEGGGG 245
Query: 86 YIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICA--WNSSDLK 128
+D G G++Q++ ++D + +L+ W + K
Sbjct: 246 KVDILRP-GGLGVEQIKKIVDEVDGGEGKTEILLLGKPWKGASFK 289
>UniRef50_Q0UYZ8 Cluster: Predicted protein; n=1; Phaeosphaeria
nodorum|Rep: Predicted protein - Phaeosphaeria nodorum
(Septoria nodorum)
Length = 337
Score = 33.9 bits (74), Expect = 4.0
Identities = 22/66 (33%), Positives = 31/66 (46%), Gaps = 3/66 (4%)
Query: 14 LTPKRVFTRGVIE---ELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGD 70
L P+ F GV + L W IS S D KA ++G+ + A+ N L R+EG
Sbjct: 135 LAPEHKFPTGVNDCWDALKWAISHSADLKATPSRGLIVGGASAGGNIAAVLALRARDEGL 194
Query: 71 LGPVYG 76
P+ G
Sbjct: 195 EPPITG 200
>UniRef50_A7TG56 Cluster: Putative uncharacterized protein; n=1;
Vanderwaltozyma polyspora DSM 70294|Rep: Putative
uncharacterized protein - Vanderwaltozyma polyspora DSM
70294
Length = 877
Score = 33.5 bits (73), Expect = 5.2
Identities = 23/59 (38%), Positives = 32/59 (54%), Gaps = 5/59 (8%)
Query: 5 SLHNNTLPLLTPKRVFTRG--VIEELLWMISGSTDSKALAAKGVHIWDANGSRNF-LDN 60
+LH T+P++ K T IEEL M G T+ +A+ A H WD + + NF LDN
Sbjct: 820 TLHTPTVPVIDRKLATTPKSLAIEELCGM--GFTEDEAVKALEKHNWDLDAATNFLLDN 876
>UniRef50_Q8TVL9 Cluster: Thymidylate synthase; n=1; Methanopyrus
kandleri|Rep: Thymidylate synthase - Methanopyrus
kandleri
Length = 209
Score = 33.5 bits (73), Expect = 5.2
Identities = 24/104 (23%), Positives = 43/104 (41%), Gaps = 3/104 (2%)
Query: 97 GIDQLQSVIDSIKNNPADRRMLICAWN-SSDLKKMALPPCHCLAQFYVADGK-LSCLLYQ 154
G+DQ+ +++ + + RR + W+ DL + + PC Q G L +
Sbjct: 99 GLDQVTKIVERLSESNNTRRAIAVTWDPRRDLDEEEV-PCLTALQLQSDGGSGLELHAFY 157
Query: 155 RSADMGLGVPFNIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVY 198
RS D+G + N+ + L +A G + + HVY
Sbjct: 158 RSWDVGKALVANMIALRRLQEHVAERAGLEPTTLTVYAANAHVY 201
>UniRef50_UPI00015B59CF Cluster: PREDICTED: similar to coagulation
factor-like protein 3; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to coagulation factor-like protein 3
- Nasonia vitripennis
Length = 351
Score = 33.1 bits (72), Expect = 6.9
Identities = 21/71 (29%), Positives = 33/71 (46%), Gaps = 1/71 (1%)
Query: 177 IAHVTGYQAGEFIHTTGDTHVYLNHIEPLKIQLQREPKQFPTLEFARKIESIDDFKYE-D 235
IA G +G+FI + G T V H+ L+ E + A +E+ DD + D
Sbjct: 124 IAFRFGNDSGDFIFSCGGTLVSSRHVVTAAHCLEYEEVSYQVRLGAHDLENTDDGSHPID 183
Query: 236 FIIKDYKPHPK 246
I++ Y HP+
Sbjct: 184 VIVESYVVHPE 194
>UniRef50_Q7PUX5 Cluster: ENSANGP00000011675; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000011675 - Anopheles gambiae
str. PEST
Length = 523
Score = 33.1 bits (72), Expect = 6.9
Identities = 28/81 (34%), Positives = 34/81 (41%), Gaps = 5/81 (6%)
Query: 150 CLLYQRSADMGLGV-PFNIASYSLLTHMIAHVTGYQAGEFIHTTGDTHVYLNHIEPLKIQ 208
C LYQ M GV PF AS L+ MI A F HT D L H+E K
Sbjct: 264 CTLYQ----MVCGVSPFRAASEYLIFKMILRCQVSYADSFDHTAKDLVTRLLHLEQAKRL 319
Query: 209 LQREPKQFPTLEFARKIESID 229
R+ ++ T+ E ID
Sbjct: 320 GARDSPRYRTIRQHAFFEGID 340
>UniRef50_A1ZKR9 Cluster: Putative uncharacterized protein; n=1;
Microscilla marina ATCC 23134|Rep: Putative
uncharacterized protein - Microscilla marina ATCC 23134
Length = 689
Score = 32.7 bits (71), Expect = 9.2
Identities = 12/34 (35%), Positives = 22/34 (64%)
Query: 17 KRVFTRGVIEELLWMISGSTDSKALAAKGVHIWD 50
K+ F ++EELL+ S+D++ ++ K H+WD
Sbjct: 141 KKKFEDRILEELLYAFDDSSDAQRISVKLSHVWD 174
>UniRef50_Q2FKU7 Cluster: Thymidylate synthase-like; n=1;
Methanospirillum hungatei JF-1|Rep: Thymidylate
synthase-like - Methanospirillum hungatei (strain JF-1 /
DSM 864)
Length = 285
Score = 32.7 bits (71), Expect = 9.2
Identities = 22/65 (33%), Positives = 31/65 (47%), Gaps = 2/65 (3%)
Query: 97 GIDQLQ-SVIDSIKNNPADRRMLICAWNSSDLKKMALPPCHCLAQFYV-ADGKLSCLLYQ 154
GIDQ+Q S+I+ + NP RR + W PPC L Q + + L+ +
Sbjct: 146 GIDQIQESIINRLIQNPESRRAISITWFPVQDITADEPPCLQLVQCVIDKNNHLNLICVF 205
Query: 155 RSADM 159
RS DM
Sbjct: 206 RSNDM 210
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.321 0.138 0.428
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 308,609,180
Number of Sequences: 1657284
Number of extensions: 13054663
Number of successful extensions: 24946
Number of sequences better than 10.0: 83
Number of HSP's better than 10.0 without gapping: 69
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 24782
Number of HSP's gapped (non-prelim): 103
length of query: 253
length of database: 575,637,011
effective HSP length: 99
effective length of query: 154
effective length of database: 411,565,895
effective search space: 63381147830
effective search space used: 63381147830
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.9 bits)
S2: 71 (32.7 bits)
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