Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001129-TA|BGIBMGA001129-PA|IPR009057|Homeodomain-like,
IPR000818|TEA/ATTS, IPR001139|Glycoside hydrolase, family 30
(671 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
X94438-1|CAA64212.2| 427|Homo sapiens transcription factor prot... 227 7e-59
BC015497-1|AAH15497.2| 434|Homo sapiens TEA domain family membe... 227 7e-59
AK222947-1|BAD96667.1| 434|Homo sapiens TEA domain family membe... 227 7e-59
BC115398-1|AAI15399.1| 357|Homo sapiens TEAD1 protein protein. 226 2e-58
M63896-1|AAB00791.1| 411|Homo sapiens transcription enhancer fa... 223 1e-57
U63824-1|AAC50763.1| 434|Homo sapiens transcription factor RTEF... 218 5e-56
AL022721-4|CAD92502.1| 447|Homo sapiens TEA domain family membe... 215 3e-55
AL022721-2|CAD92501.1| 451|Homo sapiens TEA domain family membe... 215 6e-55
X94439-1|CAA64213.2| 435|Homo sapiens transcription factor prot... 209 2e-53
BC091488-1|AAH91488.2| 435|Homo sapiens TEA domain family membe... 209 2e-53
BC010053-1|AAH10053.2| 427|Homo sapiens TEAD3 protein protein. 209 2e-53
AL022721-3|CAD92500.1| 451|Homo sapiens TEA domain family membe... 209 2e-53
AF142482-1|AAD29052.1| 435|Homo sapiens transcription enhancer ... 209 2e-53
X94440-1|CAA64214.1| 336|Homo sapiens transcription factor prot... 204 8e-52
BC007556-1|AAH07556.1| 447|Homo sapiens TEA domain family membe... 203 1e-51
BC051301-1|AAH51301.1| 450|Homo sapiens TEAD2 protein protein. 201 7e-51
AK093236-1|BAC04104.1| 450|Homo sapiens NA. protein. 201 7e-51
M19285-1|AAA35880.1| 536|Homo sapiens protein ( Human glucocere... 195 4e-49
M16328-1|AAA35873.1| 516|Homo sapiens protein ( Human glucocere... 195 4e-49
J03059-1|AAC63056.1| 536|Homo sapiens glucocerebrosidase protein. 195 4e-49
D13286-1|BAA02545.1| 536|Homo sapiens glucocerebrosidase protein. 195 4e-49
BC003356-1|AAH03356.1| 536|Homo sapiens glucosidase, beta; acid... 195 4e-49
AL713999-21|CAI95090.1| 536|Homo sapiens glucosidase, beta; aci... 195 4e-49
AL022721-1|CAD92503.1| 472|Homo sapiens TEA domain family membe... 195 4e-49
AF023268-4|AAC51820.1| 536|Homo sapiens glucocerebrosidase prot... 195 4e-49
K02920-1|AAA35877.1| 516|Homo sapiens lysosomal glucocerebrosid... 195 5e-49
AY101179-1|AAM89497.1| 384|Homo sapiens related transcription e... 184 9e-46
BC027877-1|AAH27877.1| 324|Homo sapiens TEAD3 protein protein. 113 1e-24
AB209858-1|BAD93095.1| 371|Homo sapiens TEA domain family membe... 112 4e-24
D13287-1|BAA02546.1| 263|Homo sapiens glucocerebrosidase protein. 101 6e-21
M20282-1|AAA35876.1| 54|Homo sapiens D-glucosyl-N-acylsphingos... 85 1e-15
BC092482-1|AAH92482.1| 398|Homo sapiens GBA protein protein. 61 1e-08
BC030240-1|AAH30240.1| 320|Homo sapiens GBA protein protein. 61 1e-08
BC000349-1|AAH00349.2| 359|Homo sapiens GBA protein protein. 61 1e-08
AL713999-19|CAI95088.1| 359|Homo sapiens glucosidase, beta; aci... 61 1e-08
AL157699-3|CAI41605.1| 455|Homo sapiens praja 1 protein. 33 4.3
AF264620-1|AAM53040.1| 455|Homo sapiens PRAJA1BETA protein. 33 4.3
>X94438-1|CAA64212.2| 427|Homo sapiens transcription factor
protein.
Length = 427
Score = 227 bits (556), Expect = 7e-59
Identities = 129/208 (62%), Positives = 145/208 (69%), Gaps = 24/208 (11%)
Query: 5 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 64
DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ
Sbjct: 31 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 90
Query: 65 VSSHIQVLARRKLREIQAKLKVDGGVMKEKAMQSMSTLSSAQIVA------------GLP 112
VSSHIQVLARRK REIQAKLK K+KA+QSM+ +SSAQI++ G
Sbjct: 91 VSSHIQVLARRKAREIQAKLKDQAA--KDKALQSMAAMSSAQIISATAFHSSMALARGPG 148
Query: 113 HPAYHHTQFWQPGL--QAGTSQDVKPFXXXXXXX-----XXXXXXXXXXXXTDVAPP-PP 164
PA + FWQ L QAGTS DVKPF + APP PP
Sbjct: 149 RPAV--SGFWQGALPGQAGTSHDVKPFSQQTYAVQPPLPLPGFESPAGPAPSPSAPPAPP 206
Query: 165 WEGRAIATHKLRLVEFSAFVEHPRDPDT 192
W+GR++A+ KL ++EFSAF+E +DPDT
Sbjct: 207 WQGRSVASSKLWMLEFSAFLEQQQDPDT 234
Score = 109 bits (263), Expect = 2e-23
Identities = 47/59 (79%), Positives = 53/59 (89%)
Query: 191 DTVETEYARFEGGRFVYRIHRSPMCEYMVNFIHKLKHLPEKYMMNSVLENFTILQDLNN 249
+ VETEYAR+E G + YRIHRSP+CEYM+NFIHKLKHLPEKYMMNSVLENFTILQ + N
Sbjct: 336 EKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTN 394
>BC015497-1|AAH15497.2| 434|Homo sapiens TEA domain family member 4
protein.
Length = 434
Score = 227 bits (556), Expect = 7e-59
Identities = 129/208 (62%), Positives = 145/208 (69%), Gaps = 24/208 (11%)
Query: 5 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 64
DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ
Sbjct: 38 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 97
Query: 65 VSSHIQVLARRKLREIQAKLKVDGGVMKEKAMQSMSTLSSAQIVA------------GLP 112
VSSHIQVLARRK REIQAKLK K+KA+QSM+ +SSAQI++ G
Sbjct: 98 VSSHIQVLARRKAREIQAKLKDQAA--KDKALQSMAAMSSAQIISATAFHSSMALARGPG 155
Query: 113 HPAYHHTQFWQPGL--QAGTSQDVKPFXXXXXXX-----XXXXXXXXXXXXTDVAPP-PP 164
PA + FWQ L QAGTS DVKPF + APP PP
Sbjct: 156 RPAV--SGFWQGALPGQAGTSHDVKPFSQQTYAVQPPLPLPGFESPAGPAPSPSAPPAPP 213
Query: 165 WEGRAIATHKLRLVEFSAFVEHPRDPDT 192
W+GR++A+ KL ++EFSAF+E +DPDT
Sbjct: 214 WQGRSVASSKLWMLEFSAFLEQQQDPDT 241
Score = 109 bits (263), Expect = 2e-23
Identities = 47/59 (79%), Positives = 53/59 (89%)
Query: 191 DTVETEYARFEGGRFVYRIHRSPMCEYMVNFIHKLKHLPEKYMMNSVLENFTILQDLNN 249
+ VETEYAR+E G + YRIHRSP+CEYM+NFIHKLKHLPEKYMMNSVLENFTILQ + N
Sbjct: 343 EKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTN 401
>AK222947-1|BAD96667.1| 434|Homo sapiens TEA domain family member 4
isoform 1 variant protein.
Length = 434
Score = 227 bits (556), Expect = 7e-59
Identities = 129/208 (62%), Positives = 145/208 (69%), Gaps = 24/208 (11%)
Query: 5 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 64
DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ
Sbjct: 38 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 97
Query: 65 VSSHIQVLARRKLREIQAKLKVDGGVMKEKAMQSMSTLSSAQIVA------------GLP 112
VSSHIQVLARRK REIQAKLK K+KA+QSM+ +SSAQI++ G
Sbjct: 98 VSSHIQVLARRKAREIQAKLKDQAA--KDKALQSMAAMSSAQIISATAFHSSMALARGPG 155
Query: 113 HPAYHHTQFWQPGL--QAGTSQDVKPFXXXXXXX-----XXXXXXXXXXXXTDVAPP-PP 164
PA + FWQ L QAGTS DVKPF + APP PP
Sbjct: 156 RPAV--SGFWQGALPGQAGTSHDVKPFSQQTYAVQPPLPLPGFESPAGPAPSPSAPPAPP 213
Query: 165 WEGRAIATHKLRLVEFSAFVEHPRDPDT 192
W+GR++A+ KL ++EFSAF+E +DPDT
Sbjct: 214 WQGRSVASSKLWMLEFSAFLEQQQDPDT 241
Score = 109 bits (263), Expect = 2e-23
Identities = 47/59 (79%), Positives = 53/59 (89%)
Query: 191 DTVETEYARFEGGRFVYRIHRSPMCEYMVNFIHKLKHLPEKYMMNSVLENFTILQDLNN 249
+ VETEYAR+E G + YRIHRSP+CEYM+NFIHKLKHLPEKYMMNSVLENFTILQ + N
Sbjct: 343 EKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTN 401
>BC115398-1|AAI15399.1| 357|Homo sapiens TEAD1 protein protein.
Length = 357
Score = 226 bits (552), Expect = 2e-58
Identities = 125/210 (59%), Positives = 142/210 (67%), Gaps = 20/210 (9%)
Query: 5 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 64
DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ
Sbjct: 15 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 74
Query: 65 VSSHIQVLARRKLREIQAKLKVDG--GVMKEKAMQSMSTLSSAQIVA-----------GL 111
VSSHIQVLARRK R+ +KLKV K+KA+Q M+ +SSAQIV+ G+
Sbjct: 75 VSSHIQVLARRKSRDFHSKLKVTSMDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGI 134
Query: 112 PHPAYHHTQFWQPGL----QAGTSQDVKPFXXXXXXXXXXXXXXXXXXXTDVAPP---PP 164
P P + + PG+ Q G+SQDVKPF AP P
Sbjct: 135 PRPTFPGAPGFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPASAPAPSVPA 194
Query: 165 WEGRAIATHKLRLVEFSAFVEHPRDPDTVE 194
W+GR+I T KLRLVEFSAF+E RDPD+ +
Sbjct: 195 WQGRSIGTTKLRLVEFSAFLEQQRDPDSAD 224
Score = 112 bits (269), Expect = 4e-24
Identities = 50/59 (84%), Positives = 54/59 (91%)
Query: 191 DTVETEYARFEGGRFVYRIHRSPMCEYMVNFIHKLKHLPEKYMMNSVLENFTILQDLNN 249
+ VETEYARFE GRFVYRI+RSPMCEYM+NFIHKLKHLPEKYMMNSVLENFTIL + N
Sbjct: 266 EKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTN 324
>M63896-1|AAB00791.1| 411|Homo sapiens transcription enhancer
factor protein.
Length = 411
Score = 223 bits (546), Expect = 1e-57
Identities = 124/206 (60%), Positives = 140/206 (67%), Gaps = 20/206 (9%)
Query: 5 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 64
DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ
Sbjct: 15 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 74
Query: 65 VSSHIQVLARRKLREIQAKLKVDGGVMKEKAMQSMSTLSSAQIVA-----------GLPH 113
VSSHIQVLARRK R+ +KLK K+KA+Q M+ +SSAQIV+ G+P
Sbjct: 75 VSSHIQVLARRKSRDFHSKLK--DQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPR 132
Query: 114 PAYHHTQFWQPGL----QAGTSQDVKPFXXXXXXXXXXXXXXXXXXXTDVAPP---PPWE 166
P + + PG+ Q G+SQDVKPF AP P W+
Sbjct: 133 PTFPGAPGFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPASAPAPSVPAWQ 192
Query: 167 GRAIATHKLRLVEFSAFVEHPRDPDT 192
GR+I T KLRLVEFSAF+E RDPD+
Sbjct: 193 GRSIGTTKLRLVEFSAFLEQQRDPDS 218
Score = 112 bits (269), Expect = 4e-24
Identities = 50/59 (84%), Positives = 54/59 (91%)
Query: 191 DTVETEYARFEGGRFVYRIHRSPMCEYMVNFIHKLKHLPEKYMMNSVLENFTILQDLNN 249
+ VETEYARFE GRFVYRI+RSPMCEYM+NFIHKLKHLPEKYMMNSVLENFTIL + N
Sbjct: 320 EKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTN 378
>U63824-1|AAC50763.1| 434|Homo sapiens transcription factor RTEF-1
protein.
Length = 434
Score = 218 bits (533), Expect = 5e-56
Identities = 124/206 (60%), Positives = 139/206 (67%), Gaps = 20/206 (9%)
Query: 5 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 64
D EGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ
Sbjct: 38 DGEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 97
Query: 65 VSSHIQVLARRKLREIQAKLKVDGGVMKEKAMQSMSTLSSAQIVAGLP-HPAYHHTQ--- 120
VSSHIQVLARRK REIQAKLK K+KA+QSM+ +SSAQI++ H + +
Sbjct: 98 VSSHIQVLARRKAREIQAKLKDQAA--KDKALQSMAAMSSAQIISATAFHSSMRLARGPG 155
Query: 121 ------FWQPGL--QAGTSQDVKPFXXXXXXX-----XXXXXXXXXXXXTDVAPP-PPWE 166
FWQ L QA TS DVKPF + APP PPW+
Sbjct: 156 RPAVSGFWQGALPGQAETSHDVKPFSQQTYAVQPPLPLPGFESPAGPAPSPSAPPAPPWQ 215
Query: 167 GRAIATHKLRLVEFSAFVEHPRDPDT 192
GR + KL ++EFSAF+E +DPDT
Sbjct: 216 GRRRGSSKLWMLEFSAFLEQQQDPDT 241
Score = 109 bits (263), Expect = 2e-23
Identities = 47/59 (79%), Positives = 53/59 (89%)
Query: 191 DTVETEYARFEGGRFVYRIHRSPMCEYMVNFIHKLKHLPEKYMMNSVLENFTILQDLNN 249
+ VETEYAR+E G + YRIHRSP+CEYM+NFIHKLKHLPEKYMMNSVLENFTILQ + N
Sbjct: 343 EKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTN 401
>AL022721-4|CAD92502.1| 447|Homo sapiens TEA domain family member 3
protein.
Length = 447
Score = 215 bits (526), Expect = 3e-55
Identities = 123/211 (58%), Positives = 142/211 (67%), Gaps = 25/211 (11%)
Query: 5 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 64
DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ
Sbjct: 46 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 105
Query: 65 VSSHIQVLARRKLREIQAKLKVDGGVMKEKAMQSMSTLSSAQIVAG------------LP 112
VSSH+QVLARRK REIQ+KLK V K+KA+QSM+++SSAQIV+ LP
Sbjct: 106 VSSHLQVLARRKSREIQSKLK--DQVSKDKALQSMASMSSAQIVSASVLQNKFSPPSPLP 163
Query: 113 HPAYH-HTQFWQP----GLQAGTSQDVKPFXXXXXXX------XXXXXXXXXXXXTDVAP 161
+ ++FW G Q G SQD+KPF + A
Sbjct: 164 QAVFSTSSRFWSSPPLLGQQPGPSQDIKPFAQPAYPIQPPLPPTLSSYEPLAPLPSAAAS 223
Query: 162 PPPWEGRAIATHKLRLVEFSAFVEHPRDPDT 192
P W+ R IA+ +LRL+E+SAF+E RDPDT
Sbjct: 224 VPVWQDRTIASSRLRLLEYSAFMEVQRDPDT 254
Score = 113 bits (273), Expect = 1e-24
Identities = 50/55 (90%), Positives = 52/55 (94%)
Query: 191 DTVETEYARFEGGRFVYRIHRSPMCEYMVNFIHKLKHLPEKYMMNSVLENFTILQ 245
+ VETEYAR E GRFVYRIHRSPMCEYM+NFIHKLKHLPEKYMMNSVLENFTILQ
Sbjct: 356 EKVETEYARLENGRFVYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQ 410
>AL022721-2|CAD92501.1| 451|Homo sapiens TEA domain family member 3
protein.
Length = 451
Score = 215 bits (524), Expect = 6e-55
Identities = 123/213 (57%), Positives = 142/213 (66%), Gaps = 25/213 (11%)
Query: 5 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 64
DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ
Sbjct: 46 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 105
Query: 65 VSSHIQVLARRKLREIQAKLKVDG--GVMKEKAMQSMSTLSSAQIVAG------------ 110
VSSH+QVLARRK REIQ+KLK V K+KA+QSM+++SSAQIV+
Sbjct: 106 VSSHLQVLARRKSREIQSKLKAMNLDQVSKDKALQSMASMSSAQIVSASVLQNKFSPPSP 165
Query: 111 LPHPAYH-HTQFWQP----GLQAGTSQDVKPFXXXXXXX------XXXXXXXXXXXXTDV 159
LP + ++FW G Q G SQD+KPF +
Sbjct: 166 LPQAVFSTSSRFWSSPPLLGQQPGPSQDIKPFAQPAYPIQPPLPPTLSSYEPLAPLPSAA 225
Query: 160 APPPPWEGRAIATHKLRLVEFSAFVEHPRDPDT 192
A P W+ R IA+ +LRL+E+SAF+E RDPDT
Sbjct: 226 ASVPVWQDRTIASSRLRLLEYSAFMEVQRDPDT 258
Score = 113 bits (273), Expect = 1e-24
Identities = 50/55 (90%), Positives = 52/55 (94%)
Query: 191 DTVETEYARFEGGRFVYRIHRSPMCEYMVNFIHKLKHLPEKYMMNSVLENFTILQ 245
+ VETEYAR E GRFVYRIHRSPMCEYM+NFIHKLKHLPEKYMMNSVLENFTILQ
Sbjct: 360 EKVETEYARLENGRFVYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQ 414
>X94439-1|CAA64213.2| 435|Homo sapiens transcription factor
protein.
Length = 435
Score = 209 bits (511), Expect = 2e-53
Identities = 120/213 (56%), Positives = 140/213 (65%), Gaps = 25/213 (11%)
Query: 5 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 64
DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ
Sbjct: 30 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 89
Query: 65 VSSHIQVLARRKLREIQAKLKVDG--GVMKEKAMQSMSTLSSAQIVAG------------ 110
VSSHIQVLAR+K+RE Q +K V K+KA+QSM+++SSAQIV+
Sbjct: 90 VSSHIQVLARKKVREYQVGIKAMNLDQVSKDKALQSMASMSSAQIVSASVLQNKFSPPSP 149
Query: 111 LPHPAYH-HTQFWQP----GLQAGTSQDVKPFXXXXXXX------XXXXXXXXXXXXTDV 159
LP + ++FW G Q G SQD+KPF +
Sbjct: 150 LPQAVFSTSSRFWSSPPLLGQQPGPSQDIKPFAQPAYPIQPPLPPTLSSYEPLAPLPSAA 209
Query: 160 APPPPWEGRAIATHKLRLVEFSAFVEHPRDPDT 192
A P W+ R IA+ +LRL+E+SAF+E RDPDT
Sbjct: 210 ASVPVWQDRTIASSRLRLLEYSAFMEVQRDPDT 242
Score = 113 bits (273), Expect = 1e-24
Identities = 50/55 (90%), Positives = 52/55 (94%)
Query: 191 DTVETEYARFEGGRFVYRIHRSPMCEYMVNFIHKLKHLPEKYMMNSVLENFTILQ 245
+ VETEYAR E GRFVYRIHRSPMCEYM+NFIHKLKHLPEKYMMNSVLENFTILQ
Sbjct: 344 EKVETEYARLENGRFVYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQ 398
>BC091488-1|AAH91488.2| 435|Homo sapiens TEA domain family member 3
protein.
Length = 435
Score = 209 bits (511), Expect = 2e-53
Identities = 120/213 (56%), Positives = 140/213 (65%), Gaps = 25/213 (11%)
Query: 5 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 64
DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ
Sbjct: 30 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 89
Query: 65 VSSHIQVLARRKLREIQAKLKVDG--GVMKEKAMQSMSTLSSAQIVAG------------ 110
VSSHIQVLAR+K+RE Q +K V K+KA+QSM+++SSAQIV+
Sbjct: 90 VSSHIQVLARKKVREYQVGIKAMNLDQVSKDKALQSMASMSSAQIVSASVLQNKFSPPSP 149
Query: 111 LPHPAYH-HTQFWQP----GLQAGTSQDVKPFXXXXXXX------XXXXXXXXXXXXTDV 159
LP + ++FW G Q G SQD+KPF +
Sbjct: 150 LPQAVFSTSSRFWSSPPLLGQQPGPSQDIKPFAQPAYPIQPPLPPTLSSYEPLAPLPSAA 209
Query: 160 APPPPWEGRAIATHKLRLVEFSAFVEHPRDPDT 192
A P W+ R IA+ +LRL+E+SAF+E RDPDT
Sbjct: 210 ASVPVWQDRTIASSRLRLLEYSAFMEVQRDPDT 242
Score = 113 bits (273), Expect = 1e-24
Identities = 50/55 (90%), Positives = 52/55 (94%)
Query: 191 DTVETEYARFEGGRFVYRIHRSPMCEYMVNFIHKLKHLPEKYMMNSVLENFTILQ 245
+ VETEYAR E GRFVYRIHRSPMCEYM+NFIHKLKHLPEKYMMNSVLENFTILQ
Sbjct: 344 EKVETEYARLENGRFVYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQ 398
>BC010053-1|AAH10053.2| 427|Homo sapiens TEAD3 protein protein.
Length = 427
Score = 209 bits (511), Expect = 2e-53
Identities = 120/213 (56%), Positives = 140/213 (65%), Gaps = 25/213 (11%)
Query: 5 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 64
DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ
Sbjct: 60 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 119
Query: 65 VSSHIQVLARRKLREIQAKLKVDG--GVMKEKAMQSMSTLSSAQIVAG------------ 110
VSSHIQVLAR+K+RE Q +K V K+KA+QSM+++SSAQIV+
Sbjct: 120 VSSHIQVLARKKVREYQVGIKAMNLDQVSKDKALQSMASMSSAQIVSASVLQNKFSPPSP 179
Query: 111 LPHPAYH-HTQFWQP----GLQAGTSQDVKPFXXXXXXX------XXXXXXXXXXXXTDV 159
LP + ++FW G Q G SQD+KPF +
Sbjct: 180 LPQAVFSTSSRFWSSPPLLGQQPGPSQDIKPFAQPAYPIQPPLPPTLSSYEPLAPLPSAA 239
Query: 160 APPPPWEGRAIATHKLRLVEFSAFVEHPRDPDT 192
A P W+ R IA+ +LRL+E+SAF+E RDPDT
Sbjct: 240 ASVPVWQDRTIASSRLRLLEYSAFMEVQRDPDT 272
Score = 79.0 bits (186), Expect = 5e-14
Identities = 33/38 (86%), Positives = 35/38 (92%)
Query: 191 DTVETEYARFEGGRFVYRIHRSPMCEYMVNFIHKLKHL 228
+ VETEYAR E GRFVYRIHRSPMCEYM+NFIHKLKHL
Sbjct: 374 EKVETEYARLENGRFVYRIHRSPMCEYMINFIHKLKHL 411
>AL022721-3|CAD92500.1| 451|Homo sapiens TEA domain family member 3
protein.
Length = 451
Score = 209 bits (511), Expect = 2e-53
Identities = 120/213 (56%), Positives = 140/213 (65%), Gaps = 25/213 (11%)
Query: 5 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 64
DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ
Sbjct: 46 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 105
Query: 65 VSSHIQVLARRKLREIQAKLKVDG--GVMKEKAMQSMSTLSSAQIVAG------------ 110
VSSHIQVLAR+K+RE Q +K V K+KA+QSM+++SSAQIV+
Sbjct: 106 VSSHIQVLARKKVREYQVGIKAMNLDQVSKDKALQSMASMSSAQIVSASVLQNKFSPPSP 165
Query: 111 LPHPAYH-HTQFWQP----GLQAGTSQDVKPFXXXXXXX------XXXXXXXXXXXXTDV 159
LP + ++FW G Q G SQD+KPF +
Sbjct: 166 LPQAVFSTSSRFWSSPPLLGQQPGPSQDIKPFAQPAYPIQPPLPPTLSSYEPLAPLPSAA 225
Query: 160 APPPPWEGRAIATHKLRLVEFSAFVEHPRDPDT 192
A P W+ R IA+ +LRL+E+SAF+E RDPDT
Sbjct: 226 ASVPVWQDRTIASSRLRLLEYSAFMEVQRDPDT 258
Score = 113 bits (273), Expect = 1e-24
Identities = 50/55 (90%), Positives = 52/55 (94%)
Query: 191 DTVETEYARFEGGRFVYRIHRSPMCEYMVNFIHKLKHLPEKYMMNSVLENFTILQ 245
+ VETEYAR E GRFVYRIHRSPMCEYM+NFIHKLKHLPEKYMMNSVLENFTILQ
Sbjct: 360 EKVETEYARLENGRFVYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQ 414
>AF142482-1|AAD29052.1| 435|Homo sapiens transcription enhancer
factor-5 protein.
Length = 435
Score = 209 bits (511), Expect = 2e-53
Identities = 120/213 (56%), Positives = 140/213 (65%), Gaps = 25/213 (11%)
Query: 5 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 64
DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ
Sbjct: 30 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 89
Query: 65 VSSHIQVLARRKLREIQAKLKVDG--GVMKEKAMQSMSTLSSAQIVAG------------ 110
VSSHIQVLAR+K+RE Q +K V K+KA+QSM+++SSAQIV+
Sbjct: 90 VSSHIQVLARKKVREYQVGIKAMNLDQVSKDKALQSMASMSSAQIVSASVLQNKFSPPSP 149
Query: 111 LPHPAYH-HTQFWQP----GLQAGTSQDVKPFXXXXXXX------XXXXXXXXXXXXTDV 159
LP + ++FW G Q G SQD+KPF +
Sbjct: 150 LPQAVFSTSSRFWSSPPLLGQQPGPSQDIKPFAQPAYPIQPPLPPTLSSYEPLAPLPSAA 209
Query: 160 APPPPWEGRAIATHKLRLVEFSAFVEHPRDPDT 192
A P W+ R IA+ +LRL+E+SAF+E RDPDT
Sbjct: 210 ASVPVWQDRTIASSRLRLLEYSAFMEVQRDPDT 242
Score = 115 bits (277), Expect = 5e-25
Identities = 51/59 (86%), Positives = 54/59 (91%)
Query: 191 DTVETEYARFEGGRFVYRIHRSPMCEYMVNFIHKLKHLPEKYMMNSVLENFTILQDLNN 249
+ VETEYAR E GRFVYRIHRSPMCEYM+NFIHKLKHLPEKYMMNSVLENFTILQ + N
Sbjct: 344 EKVETEYARLENGRFVYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTN 402
>X94440-1|CAA64214.1| 336|Homo sapiens transcription factor
protein.
Length = 336
Score = 204 bits (498), Expect = 8e-52
Identities = 119/210 (56%), Positives = 135/210 (64%), Gaps = 22/210 (10%)
Query: 5 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 64
DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ
Sbjct: 9 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 68
Query: 65 VSSHIQVLARRKLREIQAKLKVDGGVMKEKAMQSMSTLSSAQIVAGLP---------HPA 115
VSSHIQVLARRK REIQ+KLK V K+KA Q+M+T+SSAQ+++ L A
Sbjct: 69 VSSHIQVLARRKSREIQSKLK--DQVSKDKAFQTMATMSSAQLISALSLQAKLGPTGPQA 126
Query: 116 YHHTQFWQPGL-QAGTSQDVKPFXXXXXXXXXXXXXXXX------XXXTDVAP----PPP 164
QFW G DVKPF + + P PP
Sbjct: 127 SELFQFWSGGSGPPWNVPDVKPFSQTPFTLSLTPPSTDLPGYEPPQALSPLPPPTPSPPA 186
Query: 165 WEGRAIATHKLRLVEFSAFVEHPRDPDTVE 194
W+ R + T +L+LVEFSAFVE P D+ +
Sbjct: 187 WQARGLGTARLQLVEFSAFVEPPDAVDSYQ 216
>BC007556-1|AAH07556.1| 447|Homo sapiens TEA domain family member 2
protein.
Length = 447
Score = 203 bits (496), Expect = 1e-51
Identities = 120/210 (57%), Positives = 136/210 (64%), Gaps = 22/210 (10%)
Query: 5 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 64
DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ
Sbjct: 40 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 99
Query: 65 VSSHIQVLARRKLREIQAKLKVDGGVMKEKAMQSMSTLSSAQIVA--------GLPHP-A 115
VSSHIQVLARRK REIQ+KLK V K+KA Q+M+T+SSAQ+++ G P A
Sbjct: 100 VSSHIQVLARRKSREIQSKLK--DQVSKDKAFQTMATMSSAQLISAPSLQAKLGPTGPQA 157
Query: 116 YHHTQFWQPGL-QAGTSQDVKPFXXXXXXXXXXXXXXXX------XXXTDVAP----PPP 164
QFW G DVKPF + + P PP
Sbjct: 158 SELFQFWSGGSGPPWNVPDVKPFSQTPFTLSLTPPSTDLPGYEPPQALSPLPPPTPSPPA 217
Query: 165 WEGRAIATHKLRLVEFSAFVEHPRDPDTVE 194
W+ R + T +L+LVEFSAFVE P D+ +
Sbjct: 218 WQARGLGTARLQLVEFSAFVEPPDAVDSYQ 247
Score = 97.5 bits (232), Expect = 1e-19
Identities = 43/59 (72%), Positives = 51/59 (86%)
Query: 191 DTVETEYARFEGGRFVYRIHRSPMCEYMVNFIHKLKHLPEKYMMNSVLENFTILQDLNN 249
+ VETE A+ E GRFVYR+ RSPMCEY+VNF+HKL+ LPE+YMMNSVLENFTILQ + N
Sbjct: 356 EKVETERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTN 414
>BC051301-1|AAH51301.1| 450|Homo sapiens TEAD2 protein protein.
Length = 450
Score = 201 bits (490), Expect = 7e-51
Identities = 120/213 (56%), Positives = 136/213 (63%), Gaps = 25/213 (11%)
Query: 5 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 64
DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ
Sbjct: 40 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 99
Query: 65 VSSHIQVLARRKLREIQAKLKVDGGVMKEKAMQSMSTLSSAQIVA--------GLPHP-- 114
VSSHIQVLARRK REIQ+KLK V K+KA Q+M+T+SSAQ+++ G P
Sbjct: 100 VSSHIQVLARRKSREIQSKLK--DQVSKDKAFQTMATMSSAQLISAPSLQAKLGPTGPQV 157
Query: 115 --AYHHTQFWQPGL-QAGTSQDVKPFXXXXXXXXXXXXXXXX------XXXTDVAP---- 161
A QFW G DVKPF + + P
Sbjct: 158 VQASELFQFWSGGSGPPWNVPDVKPFSQTPFTLSLTPPSTDLPGYEPPQALSPLPPPTPS 217
Query: 162 PPPWEGRAIATHKLRLVEFSAFVEHPRDPDTVE 194
PP W+ R + T +L+LVEFSAFVE P D+ +
Sbjct: 218 PPAWQARGLGTARLQLVEFSAFVEPPDAVDSYQ 250
Score = 97.5 bits (232), Expect = 1e-19
Identities = 43/59 (72%), Positives = 51/59 (86%)
Query: 191 DTVETEYARFEGGRFVYRIHRSPMCEYMVNFIHKLKHLPEKYMMNSVLENFTILQDLNN 249
+ VETE A+ E GRFVYR+ RSPMCEY+VNF+HKL+ LPE+YMMNSVLENFTILQ + N
Sbjct: 359 EKVETERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTN 417
>AK093236-1|BAC04104.1| 450|Homo sapiens NA. protein.
Length = 450
Score = 201 bits (490), Expect = 7e-51
Identities = 120/213 (56%), Positives = 136/213 (63%), Gaps = 25/213 (11%)
Query: 5 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 64
DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ
Sbjct: 40 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 99
Query: 65 VSSHIQVLARRKLREIQAKLKVDGGVMKEKAMQSMSTLSSAQIVA--------GLPHP-- 114
VSSHIQVLARRK REIQ+KLK V K+KA Q+M+T+SSAQ+++ G P
Sbjct: 100 VSSHIQVLARRKSREIQSKLK--DQVSKDKAFQTMATMSSAQLISAPSLQAKLGPTGPQV 157
Query: 115 --AYHHTQFWQPGL-QAGTSQDVKPFXXXXXXXXXXXXXXXX------XXXTDVAP---- 161
A QFW G DVKPF + + P
Sbjct: 158 VQASELFQFWSGGSGPPWNVPDVKPFSQTPFTLSLTPPSTDLPGYEPPQALSPLPPPTPS 217
Query: 162 PPPWEGRAIATHKLRLVEFSAFVEHPRDPDTVE 194
PP W+ R + T +L+LVEFSAFVE P D+ +
Sbjct: 218 PPAWQARGLGTARLQLVEFSAFVEPPDAVDSYQ 250
Score = 97.5 bits (232), Expect = 1e-19
Identities = 43/59 (72%), Positives = 51/59 (86%)
Query: 191 DTVETEYARFEGGRFVYRIHRSPMCEYMVNFIHKLKHLPEKYMMNSVLENFTILQDLNN 249
+ VETE A+ E GRFVYR+ RSPMCEY+VNF+HKL+ LPE+YMMNSVLENFTILQ + N
Sbjct: 359 EKVETERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTN 417
>M19285-1|AAA35880.1| 536|Homo sapiens protein ( Human
glucocerebrosidase mRNA, complete cds. ).
Length = 536
Score = 195 bits (476), Expect = 4e-49
Identities = 96/206 (46%), Positives = 130/206 (63%), Gaps = 4/206 (1%)
Query: 433 WIENNLGPTIRKSVFNRTLILGVDDQRLMLSAYMLGMEKAAPNSINYLDGIAVHYYEDFV 492
+I +LGPT+ S + +L +DDQRL+L + + P + Y+ GIAVH+Y DF+
Sbjct: 298 FIARDLGPTLANSTHHNVRLLMLDDQRLLLP-HWAKVVLTDPEAAKYVHGIAVHWYLDFL 356
Query: 493 SPEILT--NLHKRYPTKIIVATEACEGAYPWETSKVKIGSWDRAQNYVKDIIEDLNNYVV 550
+P T H+ +P ++ A+EAC G+ WE S V++GSWDR Y II +L +VV
Sbjct: 357 APAKATLGETHRLFPNTMLFASEACVGSKFWEQS-VRLGSWDRGMQYSHSIITNLLYHVV 415
Query: 551 GWIDWNLCLDPNGGPNWASNFVDSPIIVYEDKGEFVKQPMYYALGHFSKFIPRGSARLQV 610
GW DWNL L+P GGPNW NFVDSPIIV K F KQPM+Y LGHFSKFIP GS R+ +
Sbjct: 416 GWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGL 475
Query: 611 TTLSTEGIENVAVITPKGNVVVVMQN 636
++ VA++ P G+ VVV+ N
Sbjct: 476 VASQKNDLDAVALMHPDGSAVVVVLN 501
Score = 106 bits (255), Expect = 2e-22
Identities = 56/126 (44%), Positives = 77/126 (61%), Gaps = 4/126 (3%)
Query: 242 TILQDLNNFVVRWIDWNLCLDPEGGPNWADNFVDSPILVYGDKDQFIKQPMFYAMGHFSK 301
+I+ +L VV W DWNL L+PEGGPNW NFVDSPI+V KD F KQPMFY +GHFSK
Sbjct: 405 SIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSK 464
Query: 302 FIYRGSRRIQVSRRSLAPIENVGLLTPNEENLLLVLQNR---VDSTIKFQTIEGFGGAVT 358
FI GS+R+ + ++ V L+ P+ +++VL V TIK + GF ++
Sbjct: 465 FIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAV-GFLETIS 523
Query: 359 DAASLN 364
S++
Sbjct: 524 PGYSIH 529
Score = 99.5 bits (237), Expect = 3e-20
Identities = 60/141 (42%), Positives = 83/141 (58%), Gaps = 13/141 (9%)
Query: 291 PMFYAMGHFSKF-IYRGSRRIQVSRRSLAPIENVGLLTPNEENLLLVLQNRVDSTIKFQT 349
P F A+G FS++ R RR+++S + PI+ LLL LQ KFQ
Sbjct: 68 PTFPALGTFSRYESTRSGRRMELS---MGPIQ----ANHTGTGLLLTLQPEQ----KFQK 116
Query: 350 IEGFGGAVTDAASLNWRKLPPAAQDKLIETYFGPNGLEYNMMRVPIGGSDFSTHPYTYNE 409
++GFGGA+TDAA+LN L P AQ+ L+++YF G+ YN++RVP+ DFS YTY +
Sbjct: 117 VKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYAD 176
Query: 410 QPWNDTELSNFSLTNEDISFK 430
P +D +L NFSL ED K
Sbjct: 177 TP-DDFQLHNFSLPEEDTKLK 196
>M16328-1|AAA35873.1| 516|Homo sapiens protein ( Human
glucocerebrosidase mRNA, complete cds. ).
Length = 516
Score = 195 bits (476), Expect = 4e-49
Identities = 96/206 (46%), Positives = 130/206 (63%), Gaps = 4/206 (1%)
Query: 433 WIENNLGPTIRKSVFNRTLILGVDDQRLMLSAYMLGMEKAAPNSINYLDGIAVHYYEDFV 492
+I +LGPT+ S + +L +DDQRL+L + + P + Y+ GIAVH+Y DF+
Sbjct: 278 FIARDLGPTLANSTHHNVRLLMLDDQRLLLP-HWAKVVLTDPEAAKYVHGIAVHWYLDFL 336
Query: 493 SPEILT--NLHKRYPTKIIVATEACEGAYPWETSKVKIGSWDRAQNYVKDIIEDLNNYVV 550
+P T H+ +P ++ A+EAC G+ WE S V++GSWDR Y II +L +VV
Sbjct: 337 APAKATLGETHRLFPNTMLFASEACVGSKFWEQS-VRLGSWDRGMQYSHSIITNLLYHVV 395
Query: 551 GWIDWNLCLDPNGGPNWASNFVDSPIIVYEDKGEFVKQPMYYALGHFSKFIPRGSARLQV 610
GW DWNL L+P GGPNW NFVDSPIIV K F KQPM+Y LGHFSKFIP GS R+ +
Sbjct: 396 GWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGL 455
Query: 611 TTLSTEGIENVAVITPKGNVVVVMQN 636
++ VA++ P G+ VVV+ N
Sbjct: 456 VASQKNDLDAVALMHPDGSAVVVVLN 481
Score = 106 bits (255), Expect = 2e-22
Identities = 56/126 (44%), Positives = 77/126 (61%), Gaps = 4/126 (3%)
Query: 242 TILQDLNNFVVRWIDWNLCLDPEGGPNWADNFVDSPILVYGDKDQFIKQPMFYAMGHFSK 301
+I+ +L VV W DWNL L+PEGGPNW NFVDSPI+V KD F KQPMFY +GHFSK
Sbjct: 385 SIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSK 444
Query: 302 FIYRGSRRIQVSRRSLAPIENVGLLTPNEENLLLVLQNR---VDSTIKFQTIEGFGGAVT 358
FI GS+R+ + ++ V L+ P+ +++VL V TIK + GF ++
Sbjct: 445 FIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAV-GFLETIS 503
Query: 359 DAASLN 364
S++
Sbjct: 504 PGYSIH 509
Score = 99.5 bits (237), Expect = 3e-20
Identities = 60/141 (42%), Positives = 83/141 (58%), Gaps = 13/141 (9%)
Query: 291 PMFYAMGHFSKF-IYRGSRRIQVSRRSLAPIENVGLLTPNEENLLLVLQNRVDSTIKFQT 349
P F A+G FS++ R RR+++S + PI+ LLL LQ KFQ
Sbjct: 48 PTFPALGTFSRYESTRSGRRMELS---MGPIQ----ANHTGTGLLLTLQPEQ----KFQK 96
Query: 350 IEGFGGAVTDAASLNWRKLPPAAQDKLIETYFGPNGLEYNMMRVPIGGSDFSTHPYTYNE 409
++GFGGA+TDAA+LN L P AQ+ L+++YF G+ YN++RVP+ DFS YTY +
Sbjct: 97 VKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYAD 156
Query: 410 QPWNDTELSNFSLTNEDISFK 430
P +D +L NFSL ED K
Sbjct: 157 TP-DDFQLHNFSLPEEDTKLK 176
>J03059-1|AAC63056.1| 536|Homo sapiens glucocerebrosidase protein.
Length = 536
Score = 195 bits (476), Expect = 4e-49
Identities = 96/206 (46%), Positives = 130/206 (63%), Gaps = 4/206 (1%)
Query: 433 WIENNLGPTIRKSVFNRTLILGVDDQRLMLSAYMLGMEKAAPNSINYLDGIAVHYYEDFV 492
+I +LGPT+ S + +L +DDQRL+L + + P + Y+ GIAVH+Y DF+
Sbjct: 298 FIARDLGPTLANSTHHNVRLLMLDDQRLLLP-HWAKVVLTDPEAAKYVHGIAVHWYLDFL 356
Query: 493 SPEILT--NLHKRYPTKIIVATEACEGAYPWETSKVKIGSWDRAQNYVKDIIEDLNNYVV 550
+P T H+ +P ++ A+EAC G+ WE S V++GSWDR Y II +L +VV
Sbjct: 357 APAKATLGETHRLFPNTMLFASEACVGSKFWEQS-VRLGSWDRGMQYSHSIITNLLYHVV 415
Query: 551 GWIDWNLCLDPNGGPNWASNFVDSPIIVYEDKGEFVKQPMYYALGHFSKFIPRGSARLQV 610
GW DWNL L+P GGPNW NFVDSPIIV K F KQPM+Y LGHFSKFIP GS R+ +
Sbjct: 416 GWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGL 475
Query: 611 TTLSTEGIENVAVITPKGNVVVVMQN 636
++ VA++ P G+ VVV+ N
Sbjct: 476 VASQKNDLDAVALMHPDGSAVVVVLN 501
Score = 107 bits (258), Expect = 9e-23
Identities = 58/132 (43%), Positives = 80/132 (60%), Gaps = 7/132 (5%)
Query: 242 TILQDLNNFVVRWIDWNLCLDPEGGPNWADNFVDSPILVYGDKDQFIKQPMFYAMGHFSK 301
+I+ +L VV W DWNL L+PEGGPNW NFVDSPI+V KD F KQPMFY +GHFSK
Sbjct: 405 SIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSK 464
Query: 302 FIYRGSRRIQVSRRSLAPIENVGLLTPNEENLLLVLQNR---VDSTIKFQTIEGFGGAVT 358
FI GS+R+ + ++ V L+ P+ +++VL V TIK + GF ++
Sbjct: 465 FIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAV-GFLETIS 523
Query: 359 DAASLN---WRK 367
S++ WR+
Sbjct: 524 PGYSIHTYLWRR 535
Score = 99.5 bits (237), Expect = 3e-20
Identities = 60/141 (42%), Positives = 83/141 (58%), Gaps = 13/141 (9%)
Query: 291 PMFYAMGHFSKF-IYRGSRRIQVSRRSLAPIENVGLLTPNEENLLLVLQNRVDSTIKFQT 349
P F A+G FS++ R RR+++S + PI+ LLL LQ KFQ
Sbjct: 68 PTFPALGTFSRYESTRSGRRMELS---MGPIQ----ANHTGTGLLLTLQPEQ----KFQK 116
Query: 350 IEGFGGAVTDAASLNWRKLPPAAQDKLIETYFGPNGLEYNMMRVPIGGSDFSTHPYTYNE 409
++GFGGA+TDAA+LN L P AQ+ L+++YF G+ YN++RVP+ DFS YTY +
Sbjct: 117 VKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYAD 176
Query: 410 QPWNDTELSNFSLTNEDISFK 430
P +D +L NFSL ED K
Sbjct: 177 TP-DDFQLHNFSLPEEDTKLK 196
>D13286-1|BAA02545.1| 536|Homo sapiens glucocerebrosidase protein.
Length = 536
Score = 195 bits (476), Expect = 4e-49
Identities = 96/206 (46%), Positives = 130/206 (63%), Gaps = 4/206 (1%)
Query: 433 WIENNLGPTIRKSVFNRTLILGVDDQRLMLSAYMLGMEKAAPNSINYLDGIAVHYYEDFV 492
+I +LGPT+ S + +L +DDQRL+L + + P + Y+ GIAVH+Y DF+
Sbjct: 298 FIARDLGPTLANSTHHNVRLLMLDDQRLLLP-HWAKVVLTDPEAAKYVHGIAVHWYLDFL 356
Query: 493 SPEILT--NLHKRYPTKIIVATEACEGAYPWETSKVKIGSWDRAQNYVKDIIEDLNNYVV 550
+P T H+ +P ++ A+EAC G+ WE S V++GSWDR Y II +L +VV
Sbjct: 357 APAKATLGETHRLFPNTMLFASEACVGSKFWEQS-VRLGSWDRGMQYSHSIITNLLYHVV 415
Query: 551 GWIDWNLCLDPNGGPNWASNFVDSPIIVYEDKGEFVKQPMYYALGHFSKFIPRGSARLQV 610
GW DWNL L+P GGPNW NFVDSPIIV K F KQPM+Y LGHFSKFIP GS R+ +
Sbjct: 416 GWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGL 475
Query: 611 TTLSTEGIENVAVITPKGNVVVVMQN 636
++ VA++ P G+ VVV+ N
Sbjct: 476 VASQKNDLDAVALMHPDGSAVVVVLN 501
Score = 107 bits (258), Expect = 9e-23
Identities = 58/132 (43%), Positives = 80/132 (60%), Gaps = 7/132 (5%)
Query: 242 TILQDLNNFVVRWIDWNLCLDPEGGPNWADNFVDSPILVYGDKDQFIKQPMFYAMGHFSK 301
+I+ +L VV W DWNL L+PEGGPNW NFVDSPI+V KD F KQPMFY +GHFSK
Sbjct: 405 SIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSK 464
Query: 302 FIYRGSRRIQVSRRSLAPIENVGLLTPNEENLLLVLQNR---VDSTIKFQTIEGFGGAVT 358
FI GS+R+ + ++ V L+ P+ +++VL V TIK + GF ++
Sbjct: 465 FIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAV-GFLETIS 523
Query: 359 DAASLN---WRK 367
S++ WR+
Sbjct: 524 PGYSIHTYLWRR 535
Score = 99.5 bits (237), Expect = 3e-20
Identities = 60/141 (42%), Positives = 83/141 (58%), Gaps = 13/141 (9%)
Query: 291 PMFYAMGHFSKF-IYRGSRRIQVSRRSLAPIENVGLLTPNEENLLLVLQNRVDSTIKFQT 349
P F A+G FS++ R RR+++S + PI+ LLL LQ KFQ
Sbjct: 68 PTFPALGTFSRYESTRSGRRMELS---MGPIQ----ANHTGTGLLLTLQPEQ----KFQK 116
Query: 350 IEGFGGAVTDAASLNWRKLPPAAQDKLIETYFGPNGLEYNMMRVPIGGSDFSTHPYTYNE 409
++GFGGA+TDAA+LN L P AQ+ L+++YF G+ YN++RVP+ DFS YTY +
Sbjct: 117 VKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYAD 176
Query: 410 QPWNDTELSNFSLTNEDISFK 430
P +D +L NFSL ED K
Sbjct: 177 TP-DDFQLHNFSLPEEDTKLK 196
>BC003356-1|AAH03356.1| 536|Homo sapiens glucosidase, beta; acid
(includes glucosylceramidase) protein.
Length = 536
Score = 195 bits (476), Expect = 4e-49
Identities = 96/206 (46%), Positives = 130/206 (63%), Gaps = 4/206 (1%)
Query: 433 WIENNLGPTIRKSVFNRTLILGVDDQRLMLSAYMLGMEKAAPNSINYLDGIAVHYYEDFV 492
+I +LGPT+ S + +L +DDQRL+L + + P + Y+ GIAVH+Y DF+
Sbjct: 298 FIARDLGPTLANSTHHNVRLLMLDDQRLLLP-HWAKVVLTDPEAAKYVHGIAVHWYLDFL 356
Query: 493 SPEILT--NLHKRYPTKIIVATEACEGAYPWETSKVKIGSWDRAQNYVKDIIEDLNNYVV 550
+P T H+ +P ++ A+EAC G+ WE S V++GSWDR Y II +L +VV
Sbjct: 357 APAKATLGETHRLFPNTMLFASEACVGSKFWEQS-VRLGSWDRGMQYSHSIITNLLYHVV 415
Query: 551 GWIDWNLCLDPNGGPNWASNFVDSPIIVYEDKGEFVKQPMYYALGHFSKFIPRGSARLQV 610
GW DWNL L+P GGPNW NFVDSPIIV K F KQPM+Y LGHFSKFIP GS R+ +
Sbjct: 416 GWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGL 475
Query: 611 TTLSTEGIENVAVITPKGNVVVVMQN 636
++ VA++ P G+ VVV+ N
Sbjct: 476 VASQKNDLDAVALMHPDGSAVVVVLN 501
Score = 107 bits (258), Expect = 9e-23
Identities = 58/132 (43%), Positives = 80/132 (60%), Gaps = 7/132 (5%)
Query: 242 TILQDLNNFVVRWIDWNLCLDPEGGPNWADNFVDSPILVYGDKDQFIKQPMFYAMGHFSK 301
+I+ +L VV W DWNL L+PEGGPNW NFVDSPI+V KD F KQPMFY +GHFSK
Sbjct: 405 SIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSK 464
Query: 302 FIYRGSRRIQVSRRSLAPIENVGLLTPNEENLLLVLQNR---VDSTIKFQTIEGFGGAVT 358
FI GS+R+ + ++ V L+ P+ +++VL V TIK + GF ++
Sbjct: 465 FIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAV-GFLETIS 523
Query: 359 DAASLN---WRK 367
S++ WR+
Sbjct: 524 PGYSIHTYLWRR 535
Score = 99.5 bits (237), Expect = 3e-20
Identities = 60/141 (42%), Positives = 83/141 (58%), Gaps = 13/141 (9%)
Query: 291 PMFYAMGHFSKF-IYRGSRRIQVSRRSLAPIENVGLLTPNEENLLLVLQNRVDSTIKFQT 349
P F A+G FS++ R RR+++S + PI+ LLL LQ KFQ
Sbjct: 68 PTFPALGTFSRYESTRSGRRMELS---MGPIQ----ANHTGTGLLLTLQPEQ----KFQK 116
Query: 350 IEGFGGAVTDAASLNWRKLPPAAQDKLIETYFGPNGLEYNMMRVPIGGSDFSTHPYTYNE 409
++GFGGA+TDAA+LN L P AQ+ L+++YF G+ YN++RVP+ DFS YTY +
Sbjct: 117 VKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYAD 176
Query: 410 QPWNDTELSNFSLTNEDISFK 430
P +D +L NFSL ED K
Sbjct: 177 TP-DDFQLHNFSLPEEDTKLK 196
>AL713999-21|CAI95090.1| 536|Homo sapiens glucosidase, beta; acid
(includes glucosylceramidase) protein.
Length = 536
Score = 195 bits (476), Expect = 4e-49
Identities = 96/206 (46%), Positives = 130/206 (63%), Gaps = 4/206 (1%)
Query: 433 WIENNLGPTIRKSVFNRTLILGVDDQRLMLSAYMLGMEKAAPNSINYLDGIAVHYYEDFV 492
+I +LGPT+ S + +L +DDQRL+L + + P + Y+ GIAVH+Y DF+
Sbjct: 298 FIARDLGPTLANSTHHNVRLLMLDDQRLLLP-HWAKVVLTDPEAAKYVHGIAVHWYLDFL 356
Query: 493 SPEILT--NLHKRYPTKIIVATEACEGAYPWETSKVKIGSWDRAQNYVKDIIEDLNNYVV 550
+P T H+ +P ++ A+EAC G+ WE S V++GSWDR Y II +L +VV
Sbjct: 357 APAKATLGETHRLFPNTMLFASEACVGSKFWEQS-VRLGSWDRGMQYSHSIITNLLYHVV 415
Query: 551 GWIDWNLCLDPNGGPNWASNFVDSPIIVYEDKGEFVKQPMYYALGHFSKFIPRGSARLQV 610
GW DWNL L+P GGPNW NFVDSPIIV K F KQPM+Y LGHFSKFIP GS R+ +
Sbjct: 416 GWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGL 475
Query: 611 TTLSTEGIENVAVITPKGNVVVVMQN 636
++ VA++ P G+ VVV+ N
Sbjct: 476 VASQKNDLDAVALMHPDGSAVVVVLN 501
Score = 107 bits (258), Expect = 9e-23
Identities = 58/132 (43%), Positives = 80/132 (60%), Gaps = 7/132 (5%)
Query: 242 TILQDLNNFVVRWIDWNLCLDPEGGPNWADNFVDSPILVYGDKDQFIKQPMFYAMGHFSK 301
+I+ +L VV W DWNL L+PEGGPNW NFVDSPI+V KD F KQPMFY +GHFSK
Sbjct: 405 SIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSK 464
Query: 302 FIYRGSRRIQVSRRSLAPIENVGLLTPNEENLLLVLQNR---VDSTIKFQTIEGFGGAVT 358
FI GS+R+ + ++ V L+ P+ +++VL V TIK + GF ++
Sbjct: 465 FIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAV-GFLETIS 523
Query: 359 DAASLN---WRK 367
S++ WR+
Sbjct: 524 PGYSIHTYLWRR 535
Score = 99.5 bits (237), Expect = 3e-20
Identities = 60/141 (42%), Positives = 83/141 (58%), Gaps = 13/141 (9%)
Query: 291 PMFYAMGHFSKF-IYRGSRRIQVSRRSLAPIENVGLLTPNEENLLLVLQNRVDSTIKFQT 349
P F A+G FS++ R RR+++S + PI+ LLL LQ KFQ
Sbjct: 68 PTFPALGTFSRYESTRSGRRMELS---MGPIQ----ANHTGTGLLLTLQPEQ----KFQK 116
Query: 350 IEGFGGAVTDAASLNWRKLPPAAQDKLIETYFGPNGLEYNMMRVPIGGSDFSTHPYTYNE 409
++GFGGA+TDAA+LN L P AQ+ L+++YF G+ YN++RVP+ DFS YTY +
Sbjct: 117 VKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYAD 176
Query: 410 QPWNDTELSNFSLTNEDISFK 430
P +D +L NFSL ED K
Sbjct: 177 TP-DDFQLHNFSLPEEDTKLK 196
>AL022721-1|CAD92503.1| 472|Homo sapiens TEA domain family member 3
protein.
Length = 472
Score = 195 bits (476), Expect = 4e-49
Identities = 121/234 (51%), Positives = 141/234 (60%), Gaps = 46/234 (19%)
Query: 5 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 64
DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ
Sbjct: 46 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 105
Query: 65 VSSHIQVLARRKLREIQAKLKVDG-----------------------GVMKEKAMQSMST 101
VSSHIQVLAR+K+RE Q +KV V K+KA+QSM++
Sbjct: 106 VSSHIQVLARKKVREYQVGIKVSSHLQVLARRKSREIQSKLKAMNLDQVSKDKALQSMAS 165
Query: 102 LSSAQIVAG------------LPHPAYH-HTQFWQP----GLQAGTSQDVKPFXXXXXXX 144
+SSAQIV+ LP + ++FW G Q G SQD+KPF
Sbjct: 166 MSSAQIVSASVLQNKFSPPSPLPQAVFSTSSRFWSSPPLLGQQPGPSQDIKPFAQPAYPI 225
Query: 145 ------XXXXXXXXXXXXTDVAPPPPWEGRAIATHKLRLVEFSAFVEHPRDPDT 192
+ A P W+ R IA+ +LRL+E+SAF+E RDPDT
Sbjct: 226 QPPLPPTLSSYEPLAPLPSAAASVPVWQDRTIASSRLRLLEYSAFMEVQRDPDT 279
Score = 113 bits (273), Expect = 1e-24
Identities = 50/55 (90%), Positives = 52/55 (94%)
Query: 191 DTVETEYARFEGGRFVYRIHRSPMCEYMVNFIHKLKHLPEKYMMNSVLENFTILQ 245
+ VETEYAR E GRFVYRIHRSPMCEYM+NFIHKLKHLPEKYMMNSVLENFTILQ
Sbjct: 381 EKVETEYARLENGRFVYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQ 435
>AF023268-4|AAC51820.1| 536|Homo sapiens glucocerebrosidase
protein.
Length = 536
Score = 195 bits (476), Expect = 4e-49
Identities = 96/206 (46%), Positives = 130/206 (63%), Gaps = 4/206 (1%)
Query: 433 WIENNLGPTIRKSVFNRTLILGVDDQRLMLSAYMLGMEKAAPNSINYLDGIAVHYYEDFV 492
+I +LGPT+ S + +L +DDQRL+L + + P + Y+ GIAVH+Y DF+
Sbjct: 298 FIARDLGPTLANSTHHNVRLLMLDDQRLLLP-HWAKVVLTDPEAAKYVHGIAVHWYLDFL 356
Query: 493 SPEILT--NLHKRYPTKIIVATEACEGAYPWETSKVKIGSWDRAQNYVKDIIEDLNNYVV 550
+P T H+ +P ++ A+EAC G+ WE S V++GSWDR Y II +L +VV
Sbjct: 357 APAKATLGETHRLFPNTMLFASEACVGSKFWEQS-VRLGSWDRGMQYSHSIITNLLYHVV 415
Query: 551 GWIDWNLCLDPNGGPNWASNFVDSPIIVYEDKGEFVKQPMYYALGHFSKFIPRGSARLQV 610
GW DWNL L+P GGPNW NFVDSPIIV K F KQPM+Y LGHFSKFIP GS R+ +
Sbjct: 416 GWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGL 475
Query: 611 TTLSTEGIENVAVITPKGNVVVVMQN 636
++ VA++ P G+ VVV+ N
Sbjct: 476 VASQKNDLDAVALMHPDGSAVVVVLN 501
Score = 107 bits (258), Expect = 9e-23
Identities = 58/132 (43%), Positives = 80/132 (60%), Gaps = 7/132 (5%)
Query: 242 TILQDLNNFVVRWIDWNLCLDPEGGPNWADNFVDSPILVYGDKDQFIKQPMFYAMGHFSK 301
+I+ +L VV W DWNL L+PEGGPNW NFVDSPI+V KD F KQPMFY +GHFSK
Sbjct: 405 SIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSK 464
Query: 302 FIYRGSRRIQVSRRSLAPIENVGLLTPNEENLLLVLQNR---VDSTIKFQTIEGFGGAVT 358
FI GS+R+ + ++ V L+ P+ +++VL V TIK + GF ++
Sbjct: 465 FIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAV-GFLETIS 523
Query: 359 DAASLN---WRK 367
S++ WR+
Sbjct: 524 PGYSIHTYLWRR 535
Score = 99.5 bits (237), Expect = 3e-20
Identities = 60/141 (42%), Positives = 83/141 (58%), Gaps = 13/141 (9%)
Query: 291 PMFYAMGHFSKF-IYRGSRRIQVSRRSLAPIENVGLLTPNEENLLLVLQNRVDSTIKFQT 349
P F A+G FS++ R RR+++S + PI+ LLL LQ KFQ
Sbjct: 68 PTFPALGTFSRYESTRSGRRMELS---MGPIQ----ANHTGTGLLLTLQPEQ----KFQK 116
Query: 350 IEGFGGAVTDAASLNWRKLPPAAQDKLIETYFGPNGLEYNMMRVPIGGSDFSTHPYTYNE 409
++GFGGA+TDAA+LN L P AQ+ L+++YF G+ YN++RVP+ DFS YTY +
Sbjct: 117 VKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYAD 176
Query: 410 QPWNDTELSNFSLTNEDISFK 430
P +D +L NFSL ED K
Sbjct: 177 TP-DDFQLHNFSLPEEDTKLK 196
>K02920-1|AAA35877.1| 516|Homo sapiens lysosomal glucocerebrosidase
precursor protein.
Length = 516
Score = 195 bits (475), Expect = 5e-49
Identities = 96/205 (46%), Positives = 129/205 (62%), Gaps = 4/205 (1%)
Query: 434 IENNLGPTIRKSVFNRTLILGVDDQRLMLSAYMLGMEKAAPNSINYLDGIAVHYYEDFVS 493
I +LGPT+ S + +L +DDQRL+L + + P + Y+ GIAVH+Y DF++
Sbjct: 279 IARDLGPTLANSTHHNVRLLMLDDQRLLLP-HWAKVVLTDPEAAKYVHGIAVHWYLDFLA 337
Query: 494 PEILT--NLHKRYPTKIIVATEACEGAYPWETSKVKIGSWDRAQNYVKDIIEDLNNYVVG 551
P T H+ +P ++ A+EAC G+ WE S V++GSWDR Y II +L +VVG
Sbjct: 338 PAKATLGETHRLFPNTMLFASEACVGSKFWEQS-VRLGSWDRGMQYSHSIITNLLYHVVG 396
Query: 552 WIDWNLCLDPNGGPNWASNFVDSPIIVYEDKGEFVKQPMYYALGHFSKFIPRGSARLQVT 611
W DWNL L+P GGPNW NFVDSPIIV K F KQPM+Y LGHFSKFIP GS R+ +
Sbjct: 397 WTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLV 456
Query: 612 TLSTEGIENVAVITPKGNVVVVMQN 636
++ VA++ P G+ VVV+ N
Sbjct: 457 ASQKNDLDAVALMHPDGSAVVVVLN 481
Score = 107 bits (258), Expect = 9e-23
Identities = 58/132 (43%), Positives = 80/132 (60%), Gaps = 7/132 (5%)
Query: 242 TILQDLNNFVVRWIDWNLCLDPEGGPNWADNFVDSPILVYGDKDQFIKQPMFYAMGHFSK 301
+I+ +L VV W DWNL L+PEGGPNW NFVDSPI+V KD F KQPMFY +GHFSK
Sbjct: 385 SIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSK 444
Query: 302 FIYRGSRRIQVSRRSLAPIENVGLLTPNEENLLLVLQNR---VDSTIKFQTIEGFGGAVT 358
FI GS+R+ + ++ V L+ P+ +++VL V TIK + GF ++
Sbjct: 445 FIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAV-GFLETIS 503
Query: 359 DAASLN---WRK 367
S++ WR+
Sbjct: 504 PGYSIHTYLWRR 515
Score = 99.5 bits (237), Expect = 3e-20
Identities = 60/141 (42%), Positives = 83/141 (58%), Gaps = 13/141 (9%)
Query: 291 PMFYAMGHFSKF-IYRGSRRIQVSRRSLAPIENVGLLTPNEENLLLVLQNRVDSTIKFQT 349
P F A+G FS++ R RR+++S + PI+ LLL LQ KFQ
Sbjct: 48 PTFPALGTFSRYESTRSGRRMELS---MGPIQ----ANHTGTGLLLTLQPEQ----KFQK 96
Query: 350 IEGFGGAVTDAASLNWRKLPPAAQDKLIETYFGPNGLEYNMMRVPIGGSDFSTHPYTYNE 409
++GFGGA+TDAA+LN L P AQ+ L+++YF G+ YN++RVP+ DFS YTY +
Sbjct: 97 VKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYAD 156
Query: 410 QPWNDTELSNFSLTNEDISFK 430
P +D +L NFSL ED K
Sbjct: 157 TP-DDFQLHNFSLPEEDTKLK 176
>AY101179-1|AAM89497.1| 384|Homo sapiens related transcription
enhancer factor 1B protein.
Length = 384
Score = 184 bits (448), Expect = 9e-46
Identities = 107/188 (56%), Positives = 121/188 (64%), Gaps = 27/188 (14%)
Query: 5 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 64
DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ
Sbjct: 31 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQ 90
Query: 65 VSSHIQVLARRKLREIQAKLKVDGGVMKEKAMQSMSTLSSAQIVAGLPHPAYHHTQFWQP 124
VSSHIQVLARRK REIQAKLK G + +A S +Q + P P
Sbjct: 91 VSSHIQVLARRKAREIQAKLKFWQGALPGQAGTSHDVKPFSQQTYAVQPP------LPLP 144
Query: 125 GLQAGTSQDVKPFXXXXXXXXXXXXXXXXXXXTDVAPPPPWEGRAIATHKLRLVEFSAFV 184
G ++ P APP W+GR++A+ KL ++EFSAF+
Sbjct: 145 GFESPAGPAPSP-------------------SAPPAPP--WQGRSVASSKLWMLEFSAFL 183
Query: 185 EHPRDPDT 192
E +DPDT
Sbjct: 184 EQQQDPDT 191
Score = 109 bits (263), Expect = 2e-23
Identities = 47/59 (79%), Positives = 53/59 (89%)
Query: 191 DTVETEYARFEGGRFVYRIHRSPMCEYMVNFIHKLKHLPEKYMMNSVLENFTILQDLNN 249
+ VETEYAR+E G + YRIHRSP+CEYM+NFIHKLKHLPEKYMMNSVLENFTILQ + N
Sbjct: 293 EKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTN 351
>BC027877-1|AAH27877.1| 324|Homo sapiens TEAD3 protein protein.
Length = 324
Score = 113 bits (273), Expect = 1e-24
Identities = 50/55 (90%), Positives = 52/55 (94%)
Query: 191 DTVETEYARFEGGRFVYRIHRSPMCEYMVNFIHKLKHLPEKYMMNSVLENFTILQ 245
+ VETEYAR E GRFVYRIHRSPMCEYM+NFIHKLKHLPEKYMMNSVLENFTILQ
Sbjct: 233 EKVETEYARLENGRFVYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQ 287
Score = 61.3 bits (142), Expect = 1e-08
Identities = 45/126 (35%), Positives = 62/126 (49%), Gaps = 23/126 (18%)
Query: 90 VMKEKAMQSMSTLSSAQIVAG------------LPHPAYH-HTQFWQP----GLQAGTSQ 132
V K+KA+QSM+++SSAQIV+ LP + ++FW G Q G SQ
Sbjct: 6 VSKDKALQSMASMSSAQIVSASVLQNKFSPPSPLPQAVFSTSSRFWSSPPLLGQQPGPSQ 65
Query: 133 DVKPFXXXXXXX------XXXXXXXXXXXXTDVAPPPPWEGRAIATHKLRLVEFSAFVEH 186
D+KPF + A P W+ R IA+ +LRL+E+SAF+E
Sbjct: 66 DIKPFAQPAYPIQPPLPPTLSSYEPLAPLPSAAASVPVWQDRTIASSRLRLLEYSAFMEV 125
Query: 187 PRDPDT 192
RDPDT
Sbjct: 126 QRDPDT 131
>AB209858-1|BAD93095.1| 371|Homo sapiens TEA domain family member 1
variant protein.
Length = 371
Score = 112 bits (269), Expect = 4e-24
Identities = 50/59 (84%), Positives = 54/59 (91%)
Query: 191 DTVETEYARFEGGRFVYRIHRSPMCEYMVNFIHKLKHLPEKYMMNSVLENFTILQDLNN 249
+ VETEYARFE GRFVYRI+RSPMCEYM+NFIHKLKHLPEKYMMNSVLENFTIL + N
Sbjct: 280 EKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTN 338
Score = 73.7 bits (173), Expect = 2e-12
Identities = 48/119 (40%), Positives = 62/119 (52%), Gaps = 18/119 (15%)
Query: 92 KEKAMQSMSTLSSAQIVA-----------GLPHPAYHHTQFWQPGL----QAGTSQDVKP 136
K+KA+Q M+ +SSAQIV+ G+P P + + PG+ Q G+SQDVKP
Sbjct: 60 KDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGAPGFWPGMIQTGQPGSSQDVKP 119
Query: 137 FXXXXXXXXXXXXXXXXXXXTDVAPPPP---WEGRAIATHKLRLVEFSAFVEHPRDPDT 192
F AP P W+GR+I T KLRLVEFSAF+E RDPD+
Sbjct: 120 FVQQAYPIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDS 178
>D13287-1|BAA02546.1| 263|Homo sapiens glucocerebrosidase protein.
Length = 263
Score = 101 bits (243), Expect = 6e-21
Identities = 51/126 (40%), Positives = 74/126 (58%), Gaps = 4/126 (3%)
Query: 433 WIENNLGPTIRKSVFNRTLILGVDDQRLMLSAYMLGMEKAAPNSINYLDGIAVHYYEDFV 492
+I +LGPT+ + +L +DDQRL+L + + P + Y+ GIAVH+Y DF+
Sbjct: 137 FIARDLGPTLANGTHHNVRLLMLDDQRLLLP-HWAKVVLTDPEAAKYVHGIAVHWYLDFL 195
Query: 493 SPE--ILTNLHKRYPTKIIVATEACEGAYPWETSKVKIGSWDRAQNYVKDIIEDLNNYVV 550
+P L H +P ++ A+EAC G+ WE S V++GSWDR Y II +L +VV
Sbjct: 196 APAKATLRETHHLFPNTMLFASEACVGSKFWEQS-VRLGSWDRGMQYSHSIITNLLYHVV 254
Query: 551 GWIDWN 556
GW DWN
Sbjct: 255 GWTDWN 260
Score = 33.1 bits (72), Expect = 3.3
Identities = 16/32 (50%), Positives = 19/32 (59%), Gaps = 1/32 (3%)
Query: 399 DFSTHPYTYNEQPWNDTELSNFSLTNEDISFK 430
DFS YTY + P +D +L NFSL ED K
Sbjct: 5 DFSIRTYTYADTP-DDFQLHNFSLPEEDTKLK 35
>M20282-1|AAA35876.1| 54|Homo sapiens D-glucosyl-N-acylsphingosine
glucohydrolase protein.
Length = 54
Score = 84.6 bits (200), Expect = 1e-15
Identities = 35/50 (70%), Positives = 38/50 (76%)
Query: 548 YVVGWIDWNLCLDPNGGPNWASNFVDSPIIVYEDKGEFVKQPMYYALGHF 597
+VVGW DWNL L+P GGPNW NFVDSPIIV K F KQPM+Y LGHF
Sbjct: 5 HVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHF 54
Score = 84.2 bits (199), Expect = 1e-15
Identities = 35/49 (71%), Positives = 38/49 (77%)
Query: 251 VVRWIDWNLCLDPEGGPNWADNFVDSPILVYGDKDQFIKQPMFYAMGHF 299
VV W DWNL L+PEGGPNW NFVDSPI+V KD F KQPMFY +GHF
Sbjct: 6 VVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHF 54
>BC092482-1|AAH92482.1| 398|Homo sapiens GBA protein protein.
Length = 398
Score = 61.3 bits (142), Expect = 1e-08
Identities = 31/62 (50%), Positives = 39/62 (62%)
Query: 575 PIIVYEDKGEFVKQPMYYALGHFSKFIPRGSARLQVTTLSTEGIENVAVITPKGNVVVVM 634
PIIV K F KQPM+Y LGHFSKFIP GS R+ + + VA++ P G+ VVV+
Sbjct: 302 PIIVDITKHTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDPDAVALMHPDGSPVVVV 361
Query: 635 QN 636
N
Sbjct: 362 LN 363
Score = 52.8 bits (121), Expect = 4e-06
Identities = 35/97 (36%), Positives = 52/97 (53%), Gaps = 7/97 (7%)
Query: 277 PILVYGDKDQFIKQPMFYAMGHFSKFIYRGSRRIQVSRRSLAPIENVGLLTPNEENLLLV 336
PI+V K F KQPMFY +GHFSKFI GS+R+ + + V L+ P+ +++V
Sbjct: 302 PIIVDITKHTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDPDAVALMHPDGSPVVVV 361
Query: 337 LQNR---VDSTIKFQTIEGFGGAVTDAASLN---WRK 367
L V TIK + GF ++ S++ WR+
Sbjct: 362 LNRSSKDVPLTIKDPAV-GFLETISPGYSIHTYLWRR 397
Score = 45.6 bits (103), Expect = 6e-04
Identities = 23/59 (38%), Positives = 33/59 (55%), Gaps = 1/59 (1%)
Query: 372 AQDKLIETYFGPNGLEYNMMRVPIGGSDFSTHPYTYNEQPWNDTELSNFSLTNEDISFK 430
A+ + I+ G+ YN++ VP+ DFS YTY + P +D +L NFSL ED K
Sbjct: 56 AEYRTIQANCTGTGIGYNIIWVPMASCDFSIRTYTYADTP-DDFQLHNFSLPEEDTKLK 113
>BC030240-1|AAH30240.1| 320|Homo sapiens GBA protein protein.
Length = 320
Score = 61.3 bits (142), Expect = 1e-08
Identities = 31/62 (50%), Positives = 39/62 (62%)
Query: 575 PIIVYEDKGEFVKQPMYYALGHFSKFIPRGSARLQVTTLSTEGIENVAVITPKGNVVVVM 634
PIIV K F KQPM+Y LGHFSKFIP GS R+ + + VA++ P G+ VVV+
Sbjct: 224 PIIVDITKHTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDPDAVALMHPDGSPVVVV 283
Query: 635 QN 636
N
Sbjct: 284 LN 285
Score = 52.8 bits (121), Expect = 4e-06
Identities = 35/97 (36%), Positives = 52/97 (53%), Gaps = 7/97 (7%)
Query: 277 PILVYGDKDQFIKQPMFYAMGHFSKFIYRGSRRIQVSRRSLAPIENVGLLTPNEENLLLV 336
PI+V K F KQPMFY +GHFSKFI GS+R+ + + V L+ P+ +++V
Sbjct: 224 PIIVDITKHTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDPDAVALMHPDGSPVVVV 283
Query: 337 LQNR---VDSTIKFQTIEGFGGAVTDAASLN---WRK 367
L V TIK + GF ++ S++ WR+
Sbjct: 284 LNRSSKDVPLTIKDPAV-GFLETISPGYSIHTYLWRR 319
Score = 33.1 bits (72), Expect = 3.3
Identities = 16/32 (50%), Positives = 19/32 (59%), Gaps = 1/32 (3%)
Query: 399 DFSTHPYTYNEQPWNDTELSNFSLTNEDISFK 430
DFS YTY + P +D +L NFSL ED K
Sbjct: 5 DFSIRTYTYADTP-DDFQLHNFSLPEEDTKLK 35
>BC000349-1|AAH00349.2| 359|Homo sapiens GBA protein protein.
Length = 359
Score = 61.3 bits (142), Expect = 1e-08
Identities = 31/62 (50%), Positives = 39/62 (62%)
Query: 575 PIIVYEDKGEFVKQPMYYALGHFSKFIPRGSARLQVTTLSTEGIENVAVITPKGNVVVVM 634
PIIV K F KQPM+Y LGHFSKFIP GS R+ + + VA++ P G+ VVV+
Sbjct: 263 PIIVDITKHTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDPDAVALMHPDGSPVVVV 322
Query: 635 QN 636
N
Sbjct: 323 LN 324
Score = 52.8 bits (121), Expect = 4e-06
Identities = 35/97 (36%), Positives = 52/97 (53%), Gaps = 7/97 (7%)
Query: 277 PILVYGDKDQFIKQPMFYAMGHFSKFIYRGSRRIQVSRRSLAPIENVGLLTPNEENLLLV 336
PI+V K F KQPMFY +GHFSKFI GS+R+ + + V L+ P+ +++V
Sbjct: 263 PIIVDITKHTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDPDAVALMHPDGSPVVVV 322
Query: 337 LQNR---VDSTIKFQTIEGFGGAVTDAASLN---WRK 367
L V TIK + GF ++ S++ WR+
Sbjct: 323 LNRSSKDVPLTIKDPAV-GFLETISPGYSIHTYLWRR 358
Score = 45.6 bits (103), Expect = 6e-04
Identities = 23/59 (38%), Positives = 33/59 (55%), Gaps = 1/59 (1%)
Query: 372 AQDKLIETYFGPNGLEYNMMRVPIGGSDFSTHPYTYNEQPWNDTELSNFSLTNEDISFK 430
A+ + I+ G+ YN++ VP+ DFS YTY + P +D +L NFSL ED K
Sbjct: 17 AEYRTIQANCTGTGIGYNIIWVPMASCDFSIRTYTYADTP-DDFQLHNFSLPEEDTKLK 74
>AL713999-19|CAI95088.1| 359|Homo sapiens glucosidase, beta; acid,
pseudogene protein.
Length = 359
Score = 61.3 bits (142), Expect = 1e-08
Identities = 31/62 (50%), Positives = 39/62 (62%)
Query: 575 PIIVYEDKGEFVKQPMYYALGHFSKFIPRGSARLQVTTLSTEGIENVAVITPKGNVVVVM 634
PIIV K F KQPM+Y LGHFSKFIP GS R+ + + VA++ P G+ VVV+
Sbjct: 263 PIIVDITKHTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDPDAVALMHPDGSPVVVV 322
Query: 635 QN 636
N
Sbjct: 323 LN 324
Score = 52.8 bits (121), Expect = 4e-06
Identities = 35/97 (36%), Positives = 52/97 (53%), Gaps = 7/97 (7%)
Query: 277 PILVYGDKDQFIKQPMFYAMGHFSKFIYRGSRRIQVSRRSLAPIENVGLLTPNEENLLLV 336
PI+V K F KQPMFY +GHFSKFI GS+R+ + + V L+ P+ +++V
Sbjct: 263 PIIVDITKHTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDPDAVALMHPDGSPVVVV 322
Query: 337 LQNR---VDSTIKFQTIEGFGGAVTDAASLN---WRK 367
L V TIK + GF ++ S++ WR+
Sbjct: 323 LNRSSKDVPLTIKDPAV-GFLETISPGYSIHTYLWRR 358
Score = 45.6 bits (103), Expect = 6e-04
Identities = 23/59 (38%), Positives = 33/59 (55%), Gaps = 1/59 (1%)
Query: 372 AQDKLIETYFGPNGLEYNMMRVPIGGSDFSTHPYTYNEQPWNDTELSNFSLTNEDISFK 430
A+ + I+ G+ YN++ VP+ DFS YTY + P +D +L NFSL ED K
Sbjct: 17 AEYRTIQANCTGTGIGYNIIWVPMASCDFSIRTYTYADTP-DDFQLHNFSLPEEDTKLK 74
>AL157699-3|CAI41605.1| 455|Homo sapiens praja 1 protein.
Length = 455
Score = 32.7 bits (71), Expect = 4.3
Identities = 22/68 (32%), Positives = 33/68 (48%), Gaps = 4/68 (5%)
Query: 369 PPAAQDKLIETYFGPNGLEYNMMR-VPIGGSDFSTHPYTYNEQPWNDTELS--NFSLTNE 425
PP +Q + I + N E M R P + S P++ + W+D+E S N ++ NE
Sbjct: 36 PPTSQRERIASQRKTNS-EVPMHRSAPSQTTKRSRSPFSTTRRSWDDSESSGTNLNIDNE 94
Query: 426 DISFKGRW 433
D S RW
Sbjct: 95 DYSSTSRW 102
>AF264620-1|AAM53040.1| 455|Homo sapiens PRAJA1BETA protein.
Length = 455
Score = 32.7 bits (71), Expect = 4.3
Identities = 22/68 (32%), Positives = 33/68 (48%), Gaps = 4/68 (5%)
Query: 369 PPAAQDKLIETYFGPNGLEYNMMR-VPIGGSDFSTHPYTYNEQPWNDTELS--NFSLTNE 425
PP +Q + I + N E M R P + S P++ + W+D+E S N ++ NE
Sbjct: 36 PPTSQRERIASQRKTNS-EVPMHRSAPSQTTKRSRSPFSTTRRSWDDSESSGTNLNIDNE 94
Query: 426 DISFKGRW 433
D S RW
Sbjct: 95 DYSSTSRW 102
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.320 0.136 0.423
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 102,269,782
Number of Sequences: 224733
Number of extensions: 4391763
Number of successful extensions: 10443
Number of sequences better than 10.0: 37
Number of HSP's better than 10.0 without gapping: 35
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 10262
Number of HSP's gapped (non-prelim): 102
length of query: 671
length of database: 73,234,838
effective HSP length: 95
effective length of query: 576
effective length of database: 51,885,203
effective search space: 29885876928
effective search space used: 29885876928
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.8 bits)
S2: 68 (31.5 bits)
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