Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001048-TA|BGIBMGA001048-PA|IPR000033|Low-density
lipoprotein receptor, YWTD repeat, IPR006209|EGF-like, IPR002172|Low
density lipoprotein-receptor, class A, IPR000152|Aspartic acid and
asparagine hydroxylation site, IPR006210|EGF
(1195 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
AF074264-1|AAC33006.1| 1613|Homo sapiens LDL receptor-related pr... 1013 0.0
BC126405-1|AAI26406.1| 1613|Homo sapiens low density lipoprotein... 1013 0.0
BC117136-1|AAI17137.1| 1613|Homo sapiens low density lipoprotein... 1013 0.0
AF283321-1|AAK52433.1| 1611|Homo sapiens low density lipoprotein... 981 0.0
AF077820-1|AAC72791.1| 1615|Homo sapiens LDL receptor member LR3... 981 0.0
AF064548-1|AAC36467.1| 1615|Homo sapiens low-density lipoprotein... 981 0.0
AB017498-1|BAA33051.1| 1615|Homo sapiens Lipoprotein Receptor Re... 981 0.0
AB209683-1|BAD92920.1| 1477|Homo sapiens low density lipoprotein... 927 0.0
AB084910-1|BAD83615.1| 1905|Homo sapiens low density lipoprotein... 788 0.0
AB011540-1|BAA32468.1| 1576|Homo sapiens MEGF7 protein. 788 0.0
AB231861-1|BAE19679.1| 1950|Homo sapiens low-density lipoprotein... 779 0.0
AF176832-1|AAF70379.1| 4599|Homo sapiens low density lipoprotein... 493 e-138
AF283374-1|AAL38108.1| 1731|Homo sapiens candidate tumor suppres... 491 e-138
X13916-1|CAA32112.1| 4544|Homo sapiens LDL-receptor related prec... 484 e-136
DQ314873-1|ABC40732.1| 4544|Homo sapiens low density lipoprotein... 484 e-136
AF058427-1|AAC64265.1| 4544|Homo sapiens lipoprotein receptor-re... 484 e-136
U33837-1|AAB41649.1| 4655|Homo sapiens gp330 precursor protein. 439 e-122
AY265358-1|AAP88586.1| 4655|Homo sapiens glycoprotein receptor g... 439 e-122
AY265357-1|AAP88585.1| 4655|Homo sapiens glycoprotein receptor g... 439 e-122
AC007556-2|AAX88965.1| 3881|Homo sapiens unknown protein. 439 e-122
AC010740-1|AAY14689.1| 862|Homo sapiens unknown protein. 285 5e-76
AF283342-1|AAL38107.1| 881|Homo sapiens candidate tumor suppres... 266 2e-70
AC073319-1|AAX93075.1| 585|Homo sapiens unknown protein. 235 9e-61
AB209498-1|BAD92735.1| 2359|Homo sapiens low density lipoprotein... 219 6e-56
AK054663-1|BAB70786.1| 820|Homo sapiens umor (LRPDIT) mRNA. pr... 214 1e-54
AF283408-1|AAL38109.1| 1537|Homo sapiens candidate tumor suppres... 211 1e-53
AB209707-1|BAD92944.1| 1720|Homo sapiens low density lipoprotein... 211 1e-53
X04571-1|CAA28240.1| 1207|Homo sapiens protein ( Human mRNA for ... 203 3e-51
BC113461-1|AAI13462.1| 1207|Homo sapiens epidermal growth factor... 203 3e-51
BC093731-1|AAH93731.1| 1207|Homo sapiens epidermal growth factor... 203 3e-51
AY506357-1|AAR84237.1| 1152|Homo sapiens truncated epidermal gro... 203 3e-51
U04441-1|AAB02882.1| 1751|Homo sapiens glycoprotein 330 protein. 199 6e-50
D86407-2|BAA21825.1| 793|Homo sapiens ApoER2delta4-7 protein. 185 7e-46
D86407-1|BAA21824.1| 963|Homo sapiens ApoER2 protein. 185 7e-46
D50678-1|BAA09328.1| 963|Homo sapiens apolipoprotein E receptor... 185 7e-46
BC051836-1|AAH51836.2| 904|Homo sapiens low density lipoprotein... 185 7e-46
AL606760-4|CAI18908.1| 963|Homo sapiens low density lipoprotein... 185 7e-46
AL606760-2|CAI18910.1| 904|Homo sapiens low density lipoprotein... 185 7e-46
AL355483-2|CAI22780.1| 904|Homo sapiens low density lipoprotein... 185 7e-46
AL355483-1|CAI22781.1| 963|Homo sapiens low density lipoprotein... 185 7e-46
Z75190-1|CAA99509.1| 699|Homo sapiens apolipoprotein E receptor... 179 6e-44
S73849-1|AAB31735.1| 873|Homo sapiens very low density lipoprot... 178 8e-44
L22431-1|AAA61344.1| 873|Homo sapiens very low density lipoprot... 178 8e-44
D16532-1|BAA03969.1| 873|Homo sapiens very low density lipoprot... 178 8e-44
D16494-1|BAA03946.1| 845|Homo sapiens very low density lipoprot... 178 8e-44
D16493-1|BAA03945.1| 873|Homo sapiens very low density lipoprot... 178 8e-44
DQ067198-1|AAY46157.1| 873|Homo sapiens very low density lipopr... 178 8e-44
AL606760-3|CAI18909.1| 700|Homo sapiens low density lipoprotein... 178 8e-44
AL450467-4|CAH72455.1| 845|Homo sapiens very low density lipopr... 178 8e-44
AL450467-3|CAH72454.1| 873|Homo sapiens very low density lipopr... 178 8e-44
AL450467-2|CAH72453.1| 752|Homo sapiens very low density lipopr... 178 8e-44
AL355483-3|CAI22782.1| 700|Homo sapiens low density lipoprotein... 178 8e-44
AK092381-1|BAC03874.1| 752|Homo sapiens protein ( Homo sapiens ... 178 8e-44
S73145-1|AAB30825.1| 268|Homo sapiens calcium sensor protein pr... 177 3e-43
L20470-1|AAA53684.1| 873|Homo sapiens very low density lipoprot... 176 3e-43
L00352-1|AAA56833.1| 860|Homo sapiens low density lipoprotein r... 173 4e-42
BT007361-1|AAP36025.1| 860|Homo sapiens low density lipoprotein... 173 4e-42
BC014514-1|AAH14514.1| 860|Homo sapiens low density lipoprotein... 173 4e-42
AY324609-1|AAP72971.1| 860|Homo sapiens low density lipoprotein... 173 4e-42
AY114155-1|AAM56036.1| 860|Homo sapiens low density lipoprotein... 173 4e-42
AC117947-1|AAX88968.1| 346|Homo sapiens unknown protein. 173 4e-42
AB209409-1|BAD92646.1| 870|Homo sapiens low density lipoprotein... 173 4e-42
AF217403-1|AAF24515.1| 837|Homo sapiens low density lipoprotein... 172 6e-42
AC008178-1|AAY24266.1| 773|Homo sapiens unknown protein. 167 2e-40
Y08110-1|CAA69325.1| 2214|Homo sapiens mosaic protein LR11 protein. 158 1e-37
U60975-1|AAC50891.2| 2214|Homo sapiens gp250 precursor protein. 158 1e-37
M27445-1|AAA57261.1| 581|Homo sapiens nidogen protein. 156 5e-37
BC045606-1|AAH45606.1| 1114|Homo sapiens NID1 protein protein. 156 5e-37
AL139161-2|CAI23422.1| 1247|Homo sapiens nidogen 1 protein. 156 5e-37
AL139161-1|CAI23421.1| 1114|Homo sapiens nidogen 1 protein. 156 5e-37
AL122018-2|CAI22681.1| 1247|Homo sapiens nidogen 1 protein. 156 5e-37
AL122018-1|CAI22680.1| 1114|Homo sapiens nidogen 1 protein. 156 5e-37
X82245-1|CAA57709.1| 1246|Homo sapiens nidogen protein. 155 9e-37
M30269-1|AAA59932.1| 1247|Homo sapiens nidogen protein. 155 9e-37
BC139736-1|AAI39737.1| 224|Homo sapiens LRP5L protein protein. 155 9e-37
D86425-1|BAA13087.1| 1376|Homo sapiens osteonidogen protein. 153 5e-36
BC035608-1|AAH35608.1| 969|Homo sapiens NID2 protein protein. 153 5e-36
AJ223500-1|CAA11418.1| 1375|Homo sapiens nidogen-2 protein. 153 5e-36
AB009799-1|BAA24112.1| 1376|Homo sapiens osteonidogen protein. 153 5e-36
AB209448-1|BAD92685.1| 1241|Homo sapiens nidogen (enactin) varia... 151 2e-35
AC068195-1|AAX93243.1| 1126|Homo sapiens unknown protein. 129 7e-29
BC021204-1|AAH21204.1| 439|Homo sapiens LRP1 protein protein. 103 4e-21
AC108036-1|AAX93208.1| 449|Homo sapiens unknown protein. 100 3e-20
AC093039-1|AAX88911.1| 425|Homo sapiens unknown protein. 90 4e-17
AC110087-1|AAY24167.1| 132|Homo sapiens unknown protein. 89 9e-17
BC113716-1|AAI13717.1| 713|Homo sapiens low density lipoprotein... 57 3e-07
BC113714-1|AAI13715.1| 713|Homo sapiens low density lipoprotein... 57 3e-07
BC064901-1|AAH64901.1| 457|Homo sapiens LRP10 protein protein. 57 3e-07
AY358399-1|AAQ88765.1| 713|Homo sapiens LRP10 protein. 57 3e-07
X55077-1|CAA38905.1| 591|Homo sapiens alpha-2 macroglobulin rec... 56 8e-07
BC088378-1|AAH88378.1| 377|Homo sapiens LRP10 protein protein. 54 2e-06
AB208822-1|BAD92059.1| 555|Homo sapiens Very low-density lipopr... 53 5e-06
AL450467-1|CAH72452.1| 173|Homo sapiens very low density lipopr... 52 9e-06
AC068287-1|AAY24318.1| 223|Homo sapiens unknown protein. 52 1e-05
L13720-1|AAA58494.1| 678|Homo sapiens growth-arrest-specific pr... 51 2e-05
BX072579-3|CAH71174.1| 678|Homo sapiens growth arrest-specific ... 51 2e-05
BC038984-1|AAH38984.1| 678|Homo sapiens growth arrest-specific ... 51 2e-05
AY256843-1|AAO84057.1| 678|Homo sapiens growth arrested-specifi... 51 2e-05
AK126533-1|BAC86580.1| 624|Homo sapiens protein ( Homo sapiens ... 51 2e-05
AB111888-1|BAC98376.1| 1322|Homo sapiens KIAA2036 protein protein. 51 2e-05
AF117899-1|AAF27280.1| 363|Homo sapiens LDLR-FUT fusion protein... 51 3e-05
BC110451-1|AAI10452.1| 1042|Homo sapiens corin, serine peptidase... 50 7e-05
AF133845-1|AAD31850.1| 1042|Homo sapiens corin protein. 50 7e-05
AL513320-1|CAI14334.1| 1229|Homo sapiens multiple EGF-like-domai... 49 1e-04
AL512413-3|CAH70834.1| 1229|Homo sapiens multiple EGF-like-domai... 49 1e-04
AB231860-1|BAE19678.1| 1640|Homo sapiens hypothetical protein pr... 49 1e-04
AB011539-1|BAA32467.2| 1246|Homo sapiens MEGF6 protein. 49 1e-04
BC126440-1|AAI26441.1| 321|Homo sapiens OIT3 protein protein. 48 2e-04
AY358339-1|AAQ88705.1| 545|Homo sapiens PPFL826 protein. 48 2e-04
AY013707-1|AAG40096.2| 545|Homo sapiens LZP protein. 48 2e-04
AK096435-1|BAC04788.1| 545|Homo sapiens protein ( Homo sapiens ... 48 2e-04
U69263-1|AAC51260.2| 956|Homo sapiens matrilin-2 precursor prot... 48 2e-04
BC016394-1|AAH16394.1| 715|Homo sapiens MATN2 protein protein. 48 2e-04
BC010444-1|AAH10444.1| 937|Homo sapiens matrilin 2 protein. 48 2e-04
AL833931-1|CAD38787.1| 1016|Homo sapiens hypothetical protein pr... 48 2e-04
AK075489-1|BAC11648.1| 451|Homo sapiens rase 7. protein. 48 2e-04
Z99756-1|CAI18854.1| 988|Homo sapiens protein ( Human DNA seque... 47 5e-04
Z82214-3|CAI21674.1| 988|Homo sapiens protein ( Human DNA seque... 47 5e-04
BC127263-1|AAI27264.1| 363|Homo sapiens SCUBE1 protein protein. 47 5e-04
AF525689-1|AAN77133.1| 988|Homo sapiens signal peptide-CUB-EGF-... 47 5e-04
BC007408-1|AAH07408.1| 770|Homo sapiens low density lipoprotein... 46 6e-04
AB009462-1|BAA32330.1| 770|Homo sapiens LDL receptor related pr... 46 6e-04
AY358895-1|AAQ89254.1| 915|Homo sapiens MATN2 protein. 46 8e-04
AK126750-1|BAC86671.1| 644|Homo sapiens protein ( Homo sapiens ... 46 8e-04
BC113577-1|AAI13578.1| 1015|Homo sapiens tolloid-like 2 protein. 46 0.001
BC112366-1|AAI12367.1| 1015|Homo sapiens tolloid-like 2 protein. 46 0.001
BC112341-1|AAI12342.1| 1015|Homo sapiens tolloid-like 2 protein. 46 0.001
AL391136-1|CAH72234.1| 1015|Homo sapiens tolloid-like 2 protein. 46 0.001
AL138765-2|CAI13580.1| 1015|Homo sapiens tolloid-like 2 protein. 46 0.001
AL136181-1|CAH72983.1| 1015|Homo sapiens tolloid-like 2 protein. 46 0.001
AF059516-1|AAD42979.1| 1015|Homo sapiens tolloid-like 2 protein ... 46 0.001
AB023149-1|BAA76776.2| 1078|Homo sapiens KIAA0932 protein protein. 46 0.001
U91963-1|AAB93878.1| 1013|Homo sapiens tolloid-like protein prot... 45 0.001
AK123039-1|BAC85521.1| 971|Homo sapiens protein ( Homo sapiens ... 45 0.001
AJ400877-1|CAB92285.1| 999|Homo sapiens CEGP1 protein protein. 45 0.001
AF282732-1|AAF86287.1| 1013|Homo sapiens tolloid-like protein pr... 45 0.001
Z98880-3|CAI42375.1| 2341|Homo sapiens v-ros UR2 sarcoma virus o... 45 0.002
Z98880-2|CAI42374.1| 2347|Homo sapiens v-ros UR2 sarcoma virus o... 45 0.002
M34353-1|AAA60278.1| 2347|Homo sapiens ROS1 protein. 45 0.002
BC105633-1|AAI05634.1| 757|Homo sapiens tumor endothelial marke... 45 0.002
BC104484-1|AAI04485.1| 757|Homo sapiens tumor endothelial marke... 45 0.002
BC051340-1|AAH51340.1| 757|Homo sapiens CD248 molecule, endosia... 45 0.002
AL132671-5|CAI23378.1| 2347|Homo sapiens v-ros UR2 sarcoma virus... 45 0.002
AL132671-4|CAI23379.1| 2341|Homo sapiens v-ros UR2 sarcoma virus... 45 0.002
AJ295846-1|CAC34381.1| 757|Homo sapiens endosialin protein prot... 45 0.002
AF279142-1|AAG00867.1| 757|Homo sapiens tumor endothelial marke... 45 0.002
BC030532-1|AAH30532.1| 855|Homo sapiens suppression of tumorige... 44 0.002
BC018146-1|AAH18146.1| 422|Homo sapiens ST14 protein protein. 44 0.002
BC005826-1|AAH05826.2| 526|Homo sapiens ST14 protein protein. 44 0.002
AF283256-1|AAG13949.1| 325|Homo sapiens serine protease SNC19 p... 44 0.002
AF133086-1|AAF00109.1| 855|Homo sapiens membrane-type serine pr... 44 0.002
AF118224-1|AAD42765.2| 855|Homo sapiens matriptase protein. 44 0.002
AF057145-1|AAG15395.1| 855|Homo sapiens serine protease TADG15 ... 44 0.002
AB030036-1|BAB20376.1| 855|Homo sapiens prostamin protein. 44 0.002
X05495-1|CAA29045.1| 575|Homo sapiens thrombomodulin protein. 44 0.003
M16552-1|AAB59508.1| 575|Homo sapiens THBD protein. 44 0.003
J02973-1|AAA61175.1| 575|Homo sapiens THBD protein. 44 0.003
D00210-1|BAA00149.1| 575|Homo sapiens thrombomodulin precursor ... 44 0.003
BC131763-1|AAI31764.1| 581|Homo sapiens matrilin 4 protein. 44 0.003
BC111690-1|AAI11691.1| 807|Homo sapiens SCUBE2 protein protein. 44 0.003
BC053357-1|AAH53357.1| 575|Homo sapiens thrombomodulin protein. 44 0.003
BC035602-1|AAH35602.2| 575|Homo sapiens thrombomodulin protein. 44 0.003
AL049651-2|CAB51954.1| 575|Homo sapiens thrombomodulin protein. 44 0.003
AL021578-3|CAB39280.1| 581|Homo sapiens matrilin 4 protein. 44 0.003
AL021578-2|CAI21077.1| 432|Homo sapiens matrilin 4 protein. 44 0.003
AL021578-1|CAB46380.1| 622|Homo sapiens matrilin 4 protein. 44 0.003
AK131552-1|BAD18686.1| 682|Homo sapiens protein ( Homo sapiens ... 44 0.003
AJ007581-1|CAA07569.1| 581|Homo sapiens matrilin-4 protein. 44 0.003
AF495471-1|AAM03232.1| 575|Homo sapiens thrombomodulin protein. 44 0.003
X12892-1|CAA31383.1| 650|Homo sapiens protein ( H.sapiens mRNA ... 44 0.004
M14338-1|AAA60181.1| 650|Homo sapiens protein S precursor protein. 44 0.004
CR456446-1|CAG30332.1| 824|Homo sapiens dJ1170K4.2 protein. 44 0.004
AY358398-1|AAQ88764.1| 802|Homo sapiens PVAE354 protein. 44 0.004
AY055384-1|AAL16414.1| 811|Homo sapiens type II transmembrane s... 44 0.004
AY055383-1|AAL16413.1| 811|Homo sapiens type II transmembrane s... 44 0.004
AL022314-2|CAI19335.1| 788|Homo sapiens protein ( Human DNA seq... 44 0.004
AK055132-1|BAB70859.1| 579|Homo sapiens protein ( Homo sapiens ... 44 0.004
AJ862823-1|CAH93521.1| 578|Homo sapiens membrane frizzled relat... 44 0.004
AJ319876-1|CAC85953.1| 802|Homo sapiens matriptase-2 protein. 44 0.004
AB055505-1|BAB39771.1| 579|Homo sapiens membrane-type frizzled-... 44 0.004
BC042754-1|AAH42754.2| 345|Homo sapiens low density lipoprotein... 43 0.006
AK075546-1|BAC11689.1| 345|Homo sapiens protein ( Homo sapiens ... 43 0.006
Y00692-1|CAA68687.1| 676|Homo sapiens preproprotein S protein. 43 0.008
X62515-1|CAA44373.1| 4393|Homo sapiens Human basement membrane h... 43 0.008
M85289-1|AAA52700.1| 4391|Homo sapiens heparan sulfate proteogly... 43 0.008
M57853-1|AAA60357.1| 676|Homo sapiens S protein protein. 43 0.008
M36564-1|AAA60180.1| 650|Homo sapiens PROS1 protein. 43 0.008
M15036-1|AAA36479.1| 676|Homo sapiens protein ( Human vitamin K... 43 0.008
BC015801-1|AAH15801.1| 676|Homo sapiens PROS1 protein protein. 43 0.008
AY308744-1|AAP45054.1| 497|Homo sapiens protein S (alpha) protein. 43 0.008
AL590556-2|CAH71870.1| 4391|Homo sapiens heparan sulfate proteog... 43 0.008
AL590103-2|CAI12125.1| 4391|Homo sapiens heparan sulfate proteog... 43 0.008
AL445795-1|CAC18534.1| 4370|Homo sapiens heparan sulfate proteog... 43 0.008
Y13341-1|CAA73785.1| 310|Homo sapiens matrilin-3 precursor prot... 42 0.010
U89336-6|AAB47494.1| 293|Homo sapiens NG3 protein. 42 0.010
BX928748-1|CAH74051.1| 5635|Homo sapiens protein ( Human DNA seq... 42 0.010
BX284686-12|CAM26220.1| 293|Homo sapiens EGF-like-domain, multi... 42 0.010
BC139907-1|AAI39908.1| 486|Homo sapiens matrilin 3 protein. 42 0.010
BC052591-1|AAH52591.1| 293|Homo sapiens EGF-like-domain, multip... 42 0.010
BC035574-1|AAH35574.1| 293|Homo sapiens EGF-like-domain, multip... 42 0.010
AY358139-1|AAQ88506.1| 293|Homo sapiens NG3 protein. 42 0.010
AY165865-1|AAO18147.1| 2809|Homo sapiens fibrillin-3 short form ... 42 0.010
AY165864-1|AAO18146.1| 2809|Homo sapiens fibrillin-3 short form ... 42 0.010
AY165863-1|AAO18145.1| 2809|Homo sapiens fibrillin-3 short form ... 42 0.010
AL845464-11|CAI41800.2| 293|Homo sapiens EGF-like-domain, multi... 42 0.010
AL662884-17|CAI18345.2| 293|Homo sapiens EGF-like-domain, multi... 42 0.010
AL662828-17|CAI17428.1| 293|Homo sapiens EGF-like-domain, multi... 42 0.010
AL391824-1|CAI17865.1| 5635|Homo sapiens protein ( Human DNA seq... 42 0.010
AL135797-1|CAI17871.1| 5635|Homo sapiens protein ( Human DNA seq... 42 0.010
AL135796-1|CAI17854.1| 5635|Homo sapiens protein ( Human DNA seq... 42 0.010
AL133553-2|CAI17858.1| 5635|Homo sapiens protein ( Human DNA seq... 42 0.010
AL133515-1|CAI17853.1| 5635|Homo sapiens protein ( Human DNA seq... 42 0.010
AL121996-1|CAI17844.1| 5635|Homo sapiens protein ( Human DNA seq... 42 0.010
AL118512-1|CAI17864.1| 5635|Homo sapiens protein ( Human DNA seq... 42 0.010
AK027344-1|BAB55049.1| 741|Homo sapiens protein ( Homo sapiens ... 42 0.010
AJ306906-1|CAC37630.1| 2673|Homo sapiens fibulin-6 protein. 42 0.010
AJ224741-1|CAA12110.1| 486|Homo sapiens matrilin-3 protein. 42 0.010
AJ001047-1|CAA04501.1| 303|Homo sapiens Matrilin-3 protein. 42 0.010
AF156100-1|AAK68690.1| 5636|Homo sapiens hemicentin protein. 42 0.010
AC079145-2|AAX88937.1| 486|Homo sapiens unknown protein. 42 0.010
AB190520-1|BAD51398.1| 293|Homo sapiens VE-statin2 protein. 42 0.010
AB177800-1|BAD16736.1| 2809|Homo sapiens fibrillin 3 protein. 42 0.010
AB177799-1|BAD16735.1| 2809|Homo sapiens fibrillin 3 protein. 42 0.010
AB177798-1|BAD16734.1| 2809|Homo sapiens fibrillin 3 protein. 42 0.010
AB177797-1|BAD16733.1| 2809|Homo sapiens fibrillin 3 protein. 42 0.010
AB053450-1|BAB47408.2| 2816|Homo sapiens fibrillin3 protein. 42 0.010
Z97832-1|CAI20187.1| 993|Homo sapiens protein ( Human DNA seque... 42 0.013
Y19124-1|CAB65555.1| 1019|Homo sapiens enteropeptidase protein. 42 0.013
U09860-1|AAC50138.1| 1019|Homo sapiens enterokinase protein. 42 0.013
BT007425-1|AAP36093.1| 513|Homo sapiens serine protease inhibit... 42 0.013
BC111749-1|AAI11750.1| 1019|Homo sapiens protease, serine, 7 (en... 42 0.013
BC047916-1|AAH47916.1| 347|Homo sapiens SCUBE1 protein protein. 42 0.013
BC018702-1|AAH18702.1| 513|Homo sapiens serine peptidase inhibi... 42 0.013
BC004140-1|AAH04140.1| 513|Homo sapiens serine peptidase inhibi... 42 0.013
AY639608-1|AAU08347.1| 993|Homo sapiens signal peptide, CUB and... 42 0.013
AY358969-1|AAQ89328.1| 529|Homo sapiens HAI-1 protein. 42 0.013
AY296715-1|AAP44001.1| 529|Homo sapiens hepatocyte growth facto... 42 0.013
AL163217-2|CAB90389.1| 904|Homo sapiens human enterokinase; EC ... 42 0.013
AF452494-1|AAN76808.1| 993|Homo sapiens CUB and EGF containing ... 42 0.013
AB000095-1|BAA25014.1| 513|Homo sapiens hepatocyte growth facto... 42 0.013
AK092062-1|BAC03798.1| 880|Homo sapiens protein ( Homo sapiens ... 42 0.018
BC126986-1|AAI26987.1| 393|Homo sapiens FLJ37440 protein protein. 41 0.031
BC052263-1|AAH52263.2| 992|Homo sapiens signal peptide, CUB dom... 41 0.031
BC043141-1|AAH43141.1| 500|Homo sapiens low density lipoprotein... 41 0.031
BC038242-1|AAH38242.1| 261|Homo sapiens Similar to RIKEN cDNA 1... 41 0.031
BC035784-1|AAH35784.1| 439|Homo sapiens hypothetical protein FL... 41 0.031
AL355312-5|CAH72865.1| 500|Homo sapiens low density lipoprotein... 41 0.031
AK094759-1|BAC04416.1| 439|Homo sapiens protein ( Homo sapiens ... 41 0.031
AK027641-1|BAB55257.1| 500|Homo sapiens protein ( Homo sapiens ... 41 0.031
AC092645-2|AAY14854.1| 439|Homo sapiens unknown protein. 41 0.031
X72177-1|CAA50994.1| 934|Homo sapiens complement component C6 p... 40 0.041
X02750-1|CAA26528.1| 461|Homo sapiens protein ( Human liver mRN... 40 0.041
M12712-1|AAA60165.1| 462|Homo sapiens PROC protein. 40 0.041
M11228-1|AAA60166.1| 461|Homo sapiens protein ( Human protein C... 40 0.041
K02059-1|AAA60164.1| 356|Homo sapiens protein C protein. 40 0.041
J05064-1|AAA51860.1| 934|Homo sapiens C6 protein. 40 0.041
J05024-1|AAA59668.1| 934|Homo sapiens completement component C6... 40 0.041
J04506-1|AAB59433.1| 491|Homo sapiens complement component C6 p... 40 0.041
BC035723-1|AAH35723.1| 934|Homo sapiens C6 protein protein. 40 0.041
BC034377-1|AAH34377.1| 461|Homo sapiens protein C (inactivator ... 40 0.041
AF378903-1|AAK56377.1| 461|Homo sapiens protein C protein. 40 0.041
AC068282-2|AAY15044.1| 461|Homo sapiens unknown protein. 40 0.041
AB126592-1|BAD02321.1| 934|Homo sapiens complement component 6 ... 40 0.041
AK027775-1|BAB55358.1| 537|Homo sapiens protein ( Homo sapiens ... 40 0.054
BC072015-1|AAH72015.1| 296|Homo sapiens LRP1 protein protein. 39 0.094
BC052593-1|AAH52593.1| 296|Homo sapiens LRP1 protein protein. 39 0.094
BC045107-1|AAH45107.1| 292|Homo sapiens LRP1 protein protein. 39 0.094
M55683-1|AAA63904.1| 340|Homo sapiens cartilage matrix protein ... 39 0.12
M55682-1|AAB38702.1| 496|Homo sapiens cartilage matrix protein ... 39 0.12
BC131710-1|AAI31711.1| 480|Homo sapiens MATN1 protein protein. 39 0.12
AL590103-10|CAI12134.1| 179|Homo sapiens heparan sulfate proteo... 39 0.12
AL137857-2|CAI19322.1| 496|Homo sapiens matrilin 1, cartilage m... 39 0.12
AK131282-1|BAD18457.1| 872|Homo sapiens protein ( Homo sapiens ... 39 0.12
X63556-1|CAA45118.1| 3002|Homo sapiens fibrillin protein. 38 0.16
X62008-1|CAB56534.1| 517|Homo sapiens fibrillin 15 protein. 38 0.16
L13923-1|AAB02036.1| 2871|Homo sapiens fibrillin protein. 38 0.16
AB177803-1|BAD16739.1| 2871|Homo sapiens fibrillin 1 protein. 38 0.16
AB177802-1|BAD16738.1| 1365|Homo sapiens fibrillin 1 protein. 38 0.16
U50330-1|AAA93462.1| 986|Homo sapiens procollagen C-proteinase ... 38 0.22
CR457140-1|CAG33421.1| 448|Homo sapiens FBLN5 protein. 38 0.22
BC032109-1|AAH32109.1| 859|Homo sapiens low density lipoprotein... 38 0.22
BC022280-1|AAH22280.1| 448|Homo sapiens fibulin 5 protein. 38 0.22
AY358898-1|AAQ89257.1| 448|Homo sapiens FBLN5 protein. 38 0.22
AK129963-1|BAC85262.1| 284|Homo sapiens protein ( Homo sapiens ... 38 0.22
AJ133490-1|CAB38568.1| 448|Homo sapiens fibulin-5 protein. 38 0.22
AF166350-1|AAD44360.1| 859|Homo sapiens ST7 protein protein. 38 0.22
AF112152-1|AAD41768.1| 448|Homo sapiens developmental arteries ... 38 0.22
AF093118-1|AAC62107.1| 448|Homo sapiens UP50 protein. 38 0.22
AB208957-1|BAD92194.1| 793|Homo sapiens suppression of tumorige... 38 0.22
Y08725-1|CAA69975.1| 717|Homo sapiens BMP1-6 protein. 38 0.29
Y08724-1|CAA69974.1| 622|Homo sapiens BMP1-5 protein. 38 0.29
M22488-1|AAA51833.1| 730|Homo sapiens BMP1 protein. 38 0.29
AL590103-5|CAI12128.1| 272|Homo sapiens low density lipoprotein... 38 0.29
AK127275-1|BAC86913.1| 272|Homo sapiens protein ( Homo sapiens ... 38 0.29
AB209590-1|BAD92827.1| 803|Homo sapiens bone morphogenetic prot... 38 0.29
AB083699-1|BAC21171.1| 43|Homo sapiens Protein C protein. 38 0.29
U03272-1|AAA18950.1| 2911|Homo sapiens fibrillin-2 protein. 37 0.38
L35279-1|AAC41710.1| 284|Homo sapiens bone morphogenetic protei... 37 0.38
D61695-1|BAA34864.1| 699|Homo sapiens mannose-binding protein a... 37 0.38
D28593-1|BAA05928.1| 699|Homo sapiens MASP protein. 37 0.38
D17525-1|BAA04477.1| 699|Homo sapiens precursor of P100 serine ... 37 0.38
BC117322-1|AAI17323.1| 572|Homo sapiens TMPRSS7 protein protein. 37 0.38
BC106946-1|AAI06947.1| 728|Homo sapiens mannan-binding lectin s... 37 0.38
BC106945-1|AAI06946.1| 728|Homo sapiens mannan-binding lectin s... 37 0.38
BC039724-1|AAH39724.1| 488|Homo sapiens MASP1 protein protein. 37 0.38
AK131211-1|BAD18401.1| 572|Homo sapiens protein ( Homo sapiens ... 37 0.38
AF284421-1|AAK84071.1| 728|Homo sapiens complement factor MASP-... 37 0.38
AF055136-1|AAC26019.1| 2155|Homo sapiens alpha-tectorin protein. 37 0.38
AB209735-1|BAD92972.1| 1976|Homo sapiens fibrillin 2 (congenital... 37 0.38
AB007617-1|BAA89206.1| 699|Homo sapiens MASP/P100 protein. 37 0.38
U95299-1|AAC32288.1| 2003|Homo sapiens Notch4 protein. 37 0.50
U89335-1|AAC63097.1| 1999|Homo sapiens notch4 protein. 37 0.50
D86566-1|BAA13116.1| 955|Homo sapiens notch related protein pro... 37 0.50
BX284927-1|CAM25850.1| 2003|Homo sapiens Notch homolog 4 (Drosop... 37 0.50
BX284686-1|CAM26209.1| 2003|Homo sapiens Notch homolog 4 (Drosop... 37 0.50
AL845509-1|CAI18564.1| 2003|Homo sapiens Notch homolog 4 (Drosop... 37 0.50
AL845464-12|CAI41803.1| 2003|Homo sapiens Notch homolog 4 (Droso... 37 0.50
AL662884-27|CAI18362.1| 2003|Homo sapiens Notch homolog 4 (Droso... 37 0.50
AL662830-9|CAI17543.1| 2005|Homo sapiens Notch homolog 4 (Drosop... 37 0.50
U94333-1|AAB53110.1| 652|Homo sapiens C1qR(p) protein. 36 0.66
U59436-1|AAB02658.1| 46|Homo sapiens low-density lipoprotein r... 36 0.66
M59303-1|AAA36499.1| 320|Homo sapiens protein Z protein. 36 0.66
M55671-1|AAA36501.1| 422|Homo sapiens protein Z protein. 36 0.66
M55670-1|AAA36500.1| 400|Homo sapiens protein Z protein. 36 0.66
BC074907-1|AAH74907.1| 400|Homo sapiens protein Z, vitamin K-de... 36 0.66
BC074906-1|AAH74906.1| 400|Homo sapiens protein Z, vitamin K-de... 36 0.66
BC028075-1|AAH28075.1| 652|Homo sapiens CD93 molecule protein. 36 0.66
AY358419-1|AAQ88785.1| 1137|Homo sapiens PLSS3001 protein. 36 0.66
AL355987-16|CAI12694.1| 1108|Homo sapiens MAM domain containing ... 36 0.66
AL355987-15|CAM14253.1| 1153|Homo sapiens MAM domain containing ... 36 0.66
AL137002-16|CAI41389.1| 422|Homo sapiens protein Z, vitamin K-d... 36 0.66
AL137002-15|CAI41388.1| 400|Homo sapiens protein Z, vitamin K-d... 36 0.66
AL118508-1|CAC00597.1| 652|Homo sapiens complement component 1,... 36 0.66
AJ295142-1|CAC82720.1| 652|Homo sapiens C1q receptor protein pr... 36 0.66
AF440358-1|AAL27631.1| 400|Homo sapiens protein Z, vitamin K-de... 36 0.66
AB209895-1|BAD93132.1| 671|Homo sapiens complement component 1,... 36 0.66
AB033749-2|BAA85764.1| 422|Homo sapiens protein Z spliced varia... 36 0.66
AB033749-1|BAA85763.1| 400|Homo sapiens protein Z protein. 36 0.66
X04701-1|CAA28407.1| 705|Homo sapiens protein ( Human mRNA for ... 36 0.87
N00045-1|AAA52764.1| 488|Homo sapiens factor X precursor protein. 36 0.87
M57285-1|AAA52421.1| 488|Homo sapiens coagulation factor X prot... 36 0.87
M22613-1|AAA51984.1| 467|Homo sapiens F10 protein. 36 0.87
M14058-1|AAA51851.1| 705|Homo sapiens C1R protein. 36 0.87
K03194-1|AAA52490.1| 476|Homo sapiens F10 protein. 36 0.87
K01886-1|AAA52486.1| 371|Homo sapiens F10 protein. 36 0.87
BC046125-1|AAH46125.1| 488|Homo sapiens coagulation factor X pr... 36 0.87
BC035220-1|AAH35220.1| 705|Homo sapiens complement component 1,... 36 0.87
AY358347-1|AAQ88713.1| 406|Homo sapiens VPPP1921 protein. 36 0.87
AY044164-1|AAK94675.1| 1244|Homo sapiens lymphocyte alpha-kinase... 36 0.87
AL137002-13|CAI41386.1| 488|Homo sapiens coagulation factor X p... 36 0.87
AL137002-12|CAI41385.1| 332|Homo sapiens coagulation factor X p... 36 0.87
AK222491-1|BAD96211.1| 705|Homo sapiens complement component 1,... 36 0.87
AK222481-1|BAD96201.1| 705|Homo sapiens complement component 1,... 36 0.87
AK131090-1|BAC85140.1| 853|Homo sapiens FLJ00302 protein protein. 36 0.87
AJ488947-1|CAD35759.1| 855|Homo sapiens polyserase-IB protein p... 36 0.87
AJ488946-1|CAD35758.1| 1059|Homo sapiens polyserase-IA protein p... 36 0.87
AF503510-1|AAM19347.1| 488|Homo sapiens coagulation factor X pr... 36 0.87
AB109390-1|BAF02295.1| 531|Homo sapiens Serase-1B protein. 36 0.87
AB083037-1|BAC19850.2| 705|Homo sapiens r subcomponent of compl... 36 0.87
AB075863-1|BAB85569.1| 418|Homo sapiens KIAA1983 protein protein. 36 0.87
AB040960-1|BAA96051.1| 801|Homo sapiens KIAA1527 protein protein. 36 0.87
BC060780-1|AAH60780.1| 1085|Homo sapiens ALPK1 protein protein. 36 1.2
X62009-1|CAB56757.1| 754|Homo sapiens fibrillin 5 protein. 35 1.5
AL133553-4|CAI17860.1| 240|Homo sapiens protein ( Human DNA seq... 35 1.5
AB208840-1|BAD92077.1| 830|Homo sapiens fibrillin 1 variant pro... 35 1.5
Z98047-1|CAI19628.1| 703|Homo sapiens fibulin 1 protein. 35 2.0
Z95331-3|CAI41717.1| 703|Homo sapiens fibulin 1 protein. 35 2.0
Y00318-2|CAA68417.1| 321|Homo sapiens protein ( Human mRNA for ... 35 2.0
Y00318-1|CAA68416.1| 565|Homo sapiens protein ( Human mRNA for ... 35 2.0
X53743-1|CAA37772.1| 683|Homo sapiens fibulin-1 C protein. 35 2.0
X53742-1|CAA37771.1| 601|Homo sapiens fibulin-1 B protein. 35 2.0
X53741-1|CAA37770.1| 566|Homo sapiens fibulin-1 A protein. 35 2.0
U01244-1|AAB17099.1| 703|Homo sapiens fibulin-1D protein. 35 2.0
J02770-1|AAA52455.1| 583|Homo sapiens IF protein. 35 2.0
BC088371-1|AAH88371.1| 273|Homo sapiens EGF-like-domain, multip... 35 2.0
BC022497-1|AAH22497.1| 683|Homo sapiens fibulin 1 protein. 35 2.0
BC020718-1|AAH20718.1| 377|Homo sapiens CFI protein protein. 35 2.0
BC012377-1|AAH12377.1| 273|Homo sapiens EGF-like-domain, multip... 35 2.0
AY358902-1|AAQ89261.1| 273|Homo sapiens VEMF protein. 35 2.0
AY358901-1|AAQ89260.1| 273|Homo sapiens VEMF protein. 35 2.0
AL021391-3|CAI18930.1| 703|Homo sapiens fibulin 1 protein. 35 2.0
AK075566-1|BAC11705.1| 638|Homo sapiens protein ( Homo sapiens ... 35 2.0
AF217999-1|AAG17241.1| 495|Homo sapiens unknown protein. 35 2.0
AF126110-1|AAK37822.1| 703|Homo sapiens fibulin-1 isoform D pre... 35 2.0
AB125649-1|BAD01469.1| 273|Homo sapiens VE-statin protein. 35 2.0
X82494-1|CAA57876.1| 1184|Homo sapiens fibulin-2 protein. 34 2.7
U03877-1|AAA65590.1| 387|Homo sapiens extracellular protein pro... 34 2.7
DQ470680-1|ABF06672.1| 373|Homo sapiens CRELD2-zeta protein. 34 2.7
DQ470679-1|ABF06671.1| 402|Homo sapiens CRELD2-epsilon protein. 34 2.7
DQ470678-1|ABF06670.1| 353|Homo sapiens CRELD2-delta protein. 34 2.7
DQ470677-1|ABF06669.1| 325|Homo sapiens CRELD2-gamma protein. 34 2.7
DQ470676-1|ABF06668.1| 321|Homo sapiens CRELD2-alpha protein. 34 2.7
BC141811-1|AAI41812.1| 540|Homo sapiens matrilin 4 protein. 34 2.7
BC098561-1|AAH98561.1| 493|Homo sapiens EGF-containing fibulin-... 34 2.7
BC051690-1|AAH51690.1| 1184|Homo sapiens fibulin 2 protein. 34 2.7
BC014410-1|AAH14410.1| 493|Homo sapiens EGF-containing fibulin-... 34 2.7
BC002894-1|AAH02894.1| 321|Homo sapiens CRELD2 protein protein. 34 2.7
AY358903-1|AAQ89262.1| 273|Homo sapiens VEMF protein. 34 2.7
AY358355-1|AAQ88721.1| 353|Homo sapiens RLPR185 protein. 34 2.7
AY130459-1|AAN05436.1| 1231|Homo sapiens fibulin 2 protein. 34 2.7
AY130458-1|AAN05435.1| 1231|Homo sapiens fibulin 2 protein. 34 2.7
AY004330-1|AAK11491.1| 493|Homo sapiens EGF-containing fibulin-... 34 2.7
AL590226-1|CAH71721.1| 273|Homo sapiens EGF-like-domain, multip... 34 2.7
AK074597-1|BAC11083.1| 540|Homo sapiens protein ( Homo sapiens ... 34 2.7
AK074595-1|BAC11081.1| 488|Homo sapiens protein ( Homo sapiens ... 34 2.7
AF186111-1|AAF01429.1| 273|Homo sapiens NOTCH4-like protein pro... 34 2.7
AC010895-1|AAY14669.1| 320|Homo sapiens unknown protein. 34 2.7
AB209212-1|BAD92449.1| 418|Homo sapiens EGF-containing fibulin-... 34 2.7
X84076-1|CAA58883.1| 550|Homo sapiens DGCR2 gene protein. 34 3.5
X83545-1|CAA58536.1| 550|Homo sapiens cell surface protein prot... 34 3.5
U08006-1|AAA82124.1| 584|Homo sapiens complement 8 alpha subuni... 34 3.5
M16974-1|AAA52200.1| 584|Homo sapiens C8A protein. 34 3.5
D79985-1|BAA11480.1| 550|Homo sapiens KIAA0163 protein. 34 3.5
CR456433-1|CAG30319.1| 550|Homo sapiens DGCR2 protein. 34 3.5
BC132913-1|AAI32914.1| 584|Homo sapiens complement component 8,... 34 3.5
BC132911-1|AAI32912.1| 584|Homo sapiens complement component 8,... 34 3.5
BC050675-1|AAH50675.1| 353|Homo sapiens cysteine-rich with EGF-... 34 3.5
BC040500-1|AAH40500.1| 550|Homo sapiens DiGeorge syndrome criti... 34 3.5
BC032430-1|AAH32430.1| 550|Homo sapiens DiGeorge syndrome criti... 34 3.5
BC020702-1|AAH20702.1| 394|Homo sapiens Unknown (protein for IM... 34 3.5
AY358884-1|AAQ89243.1| 1523|Homo sapiens SLIT3 protein. 34 3.5
AL121998-2|CAI19172.1| 584|Homo sapiens complement component 8,... 34 3.5
AF075240-1|AAD19336.1| 850|Homo sapiens SLIT1 protein protein. 34 3.5
AB017169-1|BAA35186.1| 1523|Homo sapiens Slit-3 protein protein. 34 3.5
AB011538-1|BAA32466.2| 1559|Homo sapiens MEGF5 protein. 34 3.5
D63395-1|BAA09708.1| 1095|Homo sapiens notch related protein pro... 33 4.7
CR541934-1|CAG46732.1| 443|Homo sapiens EFEMP2 protein. 33 4.7
BC074847-1|AAH74847.1| 454|Homo sapiens transmembrane protease,... 33 4.7
BC074846-1|AAH74846.1| 453|Homo sapiens transmembrane protease,... 33 4.7
BC010456-1|AAH10456.1| 443|Homo sapiens EGF-containing fibulin-... 33 4.7
AY633572-1|AAT66641.1| 538|Homo sapiens transmembrane protease ... 33 4.7
AY358899-1|AAQ89258.1| 443|Homo sapiens EFEMP2 protein. 33 4.7
AY358458-1|AAQ88823.1| 453|Homo sapiens ECHOS1 protein. 33 4.7
AK172842-1|BAD18806.1| 453|Homo sapiens protein ( Homo sapiens ... 33 4.7
AK074396-1|BAB85069.1| 220|Homo sapiens protein ( Homo sapiens ... 33 4.7
AJ132819-1|CAA10791.2| 443|Homo sapiens fibulin-4 protein. 33 4.7
AF267741-1|AAL56664.1| 344|Homo sapiens potential serine protea... 33 4.7
AF246125-1|AAF97778.1| 31|Homo sapiens enteropeptidase protein. 33 4.7
AF201380-1|AAG37012.1| 455|Homo sapiens serine protease TADG12 ... 33 4.7
AF124486-1|AAG45245.1| 443|Homo sapiens fibulin-like extracellu... 33 4.7
AF109121-1|AAF65188.1| 443|Homo sapiens EGF-containing fibulin-... 33 4.7
AF093119-1|AAC62108.1| 439|Homo sapiens UPH1 protein. 33 4.7
AB209121-1|BAD92358.1| 620|Homo sapiens Mutant p53 binding prot... 33 4.7
AB038160-1|BAB20080.1| 344|Homo sapiens serine protease protein. 33 4.7
AB038157-1|BAB20077.1| 454|Homo sapiens serine protease protein. 33 4.7
AB030655-1|BAA92880.1| 443|Homo sapiens mutant p53 binding prot... 33 4.7
M34057-1|AAA61160.1| 1394|Homo sapiens TGFB1 protein. 33 6.2
BC130289-1|AAI30290.1| 1395|Homo sapiens latent transforming gro... 33 6.2
AF489528-1|AAM03124.1| 1394|Homo sapiens transforming growth fac... 33 6.2
AC019127-1|AAY24260.1| 697|Homo sapiens unknown protein. 33 6.2
AC012353-1|AAX88846.1| 40|Homo sapiens unknown protein. 33 6.2
AB208801-1|BAD92038.1| 1348|Homo sapiens latent transforming gro... 33 6.2
Y08545-1|CAA69849.1| 533|Homo sapiens complement 9 protein. 33 8.1
X02176-1|CAA26117.1| 559|Homo sapiens protein ( Human mRNA frag... 33 8.1
K02766-1|AAA51889.1| 557|Homo sapiens C9 protein. 33 8.1
J02833-1|AAA51890.1| 98|Homo sapiens complement component C9 p... 33 8.1
BC020721-1|AAH20721.1| 559|Homo sapiens complement component 9 ... 33 8.1
AK056571-1|BAB71219.1| 955|Homo sapiens protein ( Homo sapiens ... 33 8.1
>AF074264-1|AAC33006.1| 1613|Homo sapiens LDL receptor-related protein
6 protein.
Length = 1613
Score = 1013 bits (2508), Expect = 0.0
Identities = 481/1092 (44%), Positives = 685/1092 (62%), Gaps = 22/1092 (2%)
Query: 11 TTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIA 70
T + LE AVDF + LI WSD E I+ +N+T + + +V GL++P G+A
Sbjct: 44 TIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQN--VVVSGLLSPDGLA 101
Query: 71 IDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIP 130
DW +KLYWTD ETN+IEV ++ RKVLFW E+D RAIA+ P G M+WTDWGE+P
Sbjct: 102 CDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVP 161
Query: 131 KIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRV 190
KIERAGM+G ++R +I+ I+WPNG+T+DY +YW DAKL F+ + +G R+ V
Sbjct: 162 KIERAGMDG--SSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAV 219
Query: 191 VKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESR 250
VKG L +PFALT D LYWTDW SI + G ++E+ P DI + + R
Sbjct: 220 VKGSLPHPFALTLFEDILYWTDWSTHSILACN-KYTGEGLREIHSDIFSPMDIHAFSQQR 278
Query: 251 QIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQ 310
Q + PC +N GCSHLCL+SP P Y CACPTGVKL EN T C D LL++A+
Sbjct: 279 QPNATN--PCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKT-CKDGATELLLLAR 335
Query: 311 RSTISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGS-DQ 369
R+ + +ISLD+PDFT L L+D++ + +D+DP YIYW D + I ++ +DGS Q
Sbjct: 336 RTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQ 395
Query: 370 SVVVRSSGVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHL 429
VV PD IA+D ++R +YWTD D I V RL+G+ K++I +L +PRAI L
Sbjct: 396 FVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDP 455
Query: 430 TAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKI 489
G+M+W+DW E PKIERA LDGS RV+L++ L WPN +ALD K+YWGDA+T KI
Sbjct: 456 MVGYMYWTDWGEI-PKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKI 514
Query: 490 EVCNMDGTERKELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMA 549
EV N DGT R+ L + I HIFG Q+R+++R++K + +R+ +++Q+
Sbjct: 515 EVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSA-EREVIIDQLP 573
Query: 550 NMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAF 609
++MG+KA + +G NPCA++NGGCSHLC RP C CP+G EL +D KTC+ PEAF
Sbjct: 574 DLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTCIVPEAF 633
Query: 610 LVYSRKNIIGRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNG 669
L++SR+ I R+S++ N+ IP+ +KE SAL V+ +++YW+D KTI+R +NG
Sbjct: 634 LLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNG 693
Query: 670 SAVEKIVEW-LGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSI 728
SA+E +VE+ L EG+A+DW G+N+YW DT T RIEVS+LDG R+ ++W+ L P+++
Sbjct: 694 SALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRAL 753
Query: 729 VLDPKKGYMYWSELGSK-SIKRAAMDGSSVSVFMEQVGRVHALAIDYERRAIYWAALDPP 787
LDP +G+MYW+E G K I RAAMDGS + + VGR + L IDY +R +YW LD
Sbjct: 754 ALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTN 813
Query: 788 VVEFAFLNGTGRQTLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDL 847
++E + + G R+ +AD++P P+ L + D +YW DW+ I++A KT G NR I+ L
Sbjct: 814 LIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHL 873
Query: 848 DYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS 907
DY+ D+ ++H ++ G N+C NG CSHLCL P + C CPAHY LN DN TCS
Sbjct: 874 DYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVG---GFVCGCPAHYSLNADNRTCS 930
Query: 908 EPEEFLLFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIR 967
P FLLF+QK+A+ R+++ + D +P+ L+NVRAI+YDP++KQLYW+D + IR
Sbjct: 931 APTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIR 990
Query: 968 RVPISYXXXXXXXXXXXXXXGLS-RPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTG 1026
+ L +PY + +D+ R +YWTC + IN T +D S G
Sbjct: 991 KAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGR-SVG 1049
Query: 1027 VIVRGDRMLPRHLAFHQTKRYLIWNDVGRGA--IMRANVDGTGRVEL--ARADNATALAL 1082
V+++G++ PR + + K Y+ + ++ + I RA +DGT R L + ALAL
Sbjct: 1050 VVLKGEQDRPRAIVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALAL 1109
Query: 1083 DQSAGTVYWAVS 1094
D G ++WA S
Sbjct: 1110 DSRLGKLFWADS 1121
Score = 555 bits (1371), Expect = e-157
Identities = 322/924 (34%), Positives = 494/924 (53%), Gaps = 37/924 (4%)
Query: 2 VNTSRLTRITTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSE 61
++T T I +D+ A+D+ + I W+D + I+ + + G +F +V+
Sbjct: 344 LDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGS--GSQF-VVTA 400
Query: 62 GLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLM 121
+ P GIA+DW LYWTD T++IEV + RK+L +++ RAI + P G M
Sbjct: 401 QIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYM 460
Query: 122 FWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVID 181
+WTDWGEIPKIERA ++G + R V+V ++ WPNG+ +DY+ IYW DAK ++V++
Sbjct: 461 YWTDWGEIPKIERAALDG--SDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMN 518
Query: 182 FNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPA 241
+G R+ +V+ + + F T D +YWTDWQ SI + + + +I P
Sbjct: 519 TDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIER--VHKRSAEREVIIDQLPDLM 576
Query: 242 DIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDS 301
+K + R I S PC + N GCSHLCL P G CACP G +L + T
Sbjct: 577 GLKATNVHRVIGSN---PCAEENGGCSHLCLYRPQ--GLRCACPIGFELISDMKTCIV-- 629
Query: 302 PQMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISK 361
P+ L+ ++R+ I +ISL++ + +PL +K +DFD IYW D KTIS+
Sbjct: 630 PEAFLLFSRRADIRRISLETNN-NNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISR 688
Query: 362 ARLDGSD-QSVVVRSSGVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELY 420
A ++GS + VV P+ +A+D L + +YW D + I V++LDG + +V++ +L
Sbjct: 689 AFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLD 748
Query: 421 DPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLY 480
PRA+AL G+M+W++W K PKI+RA +DGS R L+ + N + +D +LY
Sbjct: 749 SPRALALDPAEGFMYWTEWGGK-PKIDRAAMDGSERTTLVPN-VGRANGLTIDYAKRRLY 806
Query: 481 WGDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLD 540
W D T+ IE NM G R E+ ++D+ H FG +R+++R NK +G +
Sbjct: 807 WTDLDTNLIESSNMLGLNR-EVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQN 865
Query: 541 RQPVVEQMANMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRP-DDYICGCPLGLELTAD 599
R + + +M + F GWN CA NG CSHLC P ++CGCP L AD
Sbjct: 866 RTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNAD 925
Query: 600 KKTCVEPEAFLVYSRKNIIGRLSIKNEYN-DAVIPIKDLKEVSALALYVSGSKLYWSDSK 658
+TC P FL++S+K+ I R+ I + + D ++PI L+ V A+ +LYW DS+
Sbjct: 926 NRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSR 985
Query: 659 TKTINRCSVNGSAVEKIV------EWLGLVE-GLAIDWSGQNIYWTDTTTQRIEVSRLDG 711
I + +GS +V + L + L+ID + IYWT T I V+RLDG
Sbjct: 986 QNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDG 1045
Query: 712 SSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS--IKRAAMDGSSVSV-FMEQVGRVH 768
S ++ +P++IV++P+KGYMY++ L +S I+RAA+DG+ V F + +
Sbjct: 1046 RSVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPI 1105
Query: 769 ALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLAD-NIPMPYALALFNDSVYWGDWNTG 827
ALA+D ++WA D +E + L+G R L D NI P L +F + +YW D
Sbjct: 1106 ALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQ 1165
Query: 828 QIQQARKTDGSNRKSIRKDLDYISDLKLYHRAKSMGSNQ--CGVDNGGCSHLCLPTPGDV 885
I++ T R ++ + +SD+ Q C DNGGCSH+CL GD
Sbjct: 1166 MIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICL-VKGDG 1224
Query: 886 RTDYRCACPAHYRLNKDNITCSEP 909
T RC+CP H L +D ++C EP
Sbjct: 1225 TT--RCSCPMHLVLLQDELSCGEP 1246
Score = 304 bits (746), Expect = 1e-81
Identities = 168/492 (34%), Positives = 258/492 (52%), Gaps = 18/492 (3%)
Query: 610 LVYSRKNIIGRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNG 669
L+Y+ + + + N +A I + L++ +A+ S +YWSD + I R N
Sbjct: 23 LLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNK 82
Query: 670 SAVEKIVEWLGLV--EGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKS 727
+ + V GL+ +GLA DW G+ +YWTD+ T RIEVS LDGS R+ + WQ L +P++
Sbjct: 83 TESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRA 142
Query: 728 IVLDPKKGYMYWSELGS-KSIKRAAMDGSSVSVFM-EQVGRVHALAIDYERRAIYWAALD 785
I LDP G+MYW++ G I+RA MDGSS + + ++ + L +DYE + +YWA
Sbjct: 143 IALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADAK 202
Query: 786 PPVVEFAFLNGTGRQTLA-DNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIR 844
+ + L+GT RQ + ++P P+AL LF D +YW DW+T I K G + I
Sbjct: 203 LNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIH 262
Query: 845 KDLDYISDLKLYHRAKS-MGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDN 903
D+ D+ + + + +N CG+DNGGCSHLCL +P V+ Y+CACP +L ++
Sbjct: 263 SDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSP--VKPFYQCACPTGVKLLENG 320
Query: 904 ITCSE-PEEFLLFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDD 962
TC + E LL A++ + RI + + D + L +++ AI+YDPVE +YW DD+
Sbjct: 321 KTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDE 380
Query: 963 SHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNN 1022
+IRR I ++ P + +D + R +YWT D I T + N
Sbjct: 381 VRAIRRSFID-----GSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRL-NG 434
Query: 1023 SSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGR-GAIMRANVDGTGRVELARADNA--TA 1079
+ +++ D PR + Y+ W D G I RA +DG+ RV L
Sbjct: 435 TMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNG 494
Query: 1080 LALDQSAGTVYW 1091
LALD G +YW
Sbjct: 495 LALDYDEGKIYW 506
Score = 44.0 bits (99), Expect = 0.003
Identities = 28/92 (30%), Positives = 33/92 (35%), Gaps = 10/92 (10%)
Query: 1093 VSRQCDGQQDCEDGRDEAECGACG-GDVRCADGTXXXXXXXXXXXXXXXXXXXX------ 1145
V+ +CDG +CED DE C C +CA G
Sbjct: 1266 VAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVL 1325
Query: 1146 ---DAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
D FRC G CI CD C+D SDE
Sbjct: 1326 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDE 1357
>BC126405-1|AAI26406.1| 1613|Homo sapiens low density lipoprotein
receptor-related protein 6 protein.
Length = 1613
Score = 1013 bits (2507), Expect = 0.0
Identities = 481/1092 (44%), Positives = 685/1092 (62%), Gaps = 22/1092 (2%)
Query: 11 TTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIA 70
T + LE AVDF + LI WSD E I+ +N+T + + +V GL++P G+A
Sbjct: 44 TIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQN--VVVSGLLSPDGLA 101
Query: 71 IDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIP 130
DW +KLYWTD ETN+IEV ++ RKVLFW E+D RAIA+ P G M+WTDWGE+P
Sbjct: 102 CDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVP 161
Query: 131 KIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRV 190
KIERAGM+G ++R +I+ I+WPNG+T+DY +YW DAKL F+ + +G R+ V
Sbjct: 162 KIERAGMDG--SSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAV 219
Query: 191 VKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESR 250
VKG L +PFALT D LYWTDW SI + G ++E+ P DI + + R
Sbjct: 220 VKGSLPHPFALTLFEDILYWTDWSTHSILACN-KYTGEGLREIHSDIFSPMDIHAFSQQR 278
Query: 251 QIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQ 310
Q + PC +N GCSHLCL+SP P Y CACPTGVKL EN T C D LL++A+
Sbjct: 279 QPNATN--PCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKT-CKDGATELLLLAR 335
Query: 311 RSTISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGS-DQ 369
R+ + +ISLD+PDFT L L+D++ + +D+DP YIYW D + I ++ +DGS Q
Sbjct: 336 RTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQ 395
Query: 370 SVVVRSSGVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHL 429
VV PD IA+D ++R +YWTD D I V RL+G+ K++I +L +PRAI L
Sbjct: 396 FVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDP 455
Query: 430 TAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKI 489
G+M+W+DW E PKIERA LDGS RV+L++ L WPN +ALD K+YWGDA+T KI
Sbjct: 456 MVGYMYWTDWGEI-PKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKI 514
Query: 490 EVCNMDGTERKELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMA 549
EV N DGT R+ L + I HIFG Q+R+++R++K + +R+ +++Q+
Sbjct: 515 EVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSA-EREVIIDQLP 573
Query: 550 NMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAF 609
++MG+KA + +G NPCA++NGGCSHLC RP C CP+G EL +D KTC+ PEAF
Sbjct: 574 DLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTCIVPEAF 633
Query: 610 LVYSRKNIIGRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNG 669
L++SR+ I R+S++ N+ IP+ +KE SAL V+ +++YW+D KTI+R +NG
Sbjct: 634 LLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNG 693
Query: 670 SAVEKIVEW-LGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSI 728
SA+E +VE+ L EG+A+DW G+N+YW DT T RIEVS+LDG R+ ++W+ L P+++
Sbjct: 694 SALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRAL 753
Query: 729 VLDPKKGYMYWSELGSK-SIKRAAMDGSSVSVFMEQVGRVHALAIDYERRAIYWAALDPP 787
LDP +G+MYW+E G K I RAAMDGS + + VGR + L IDY +R +YW LD
Sbjct: 754 ALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTN 813
Query: 788 VVEFAFLNGTGRQTLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDL 847
++E + + G R+ +AD++P P+ L + D +YW DW+ I++A KT G NR I+ L
Sbjct: 814 LIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHL 873
Query: 848 DYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS 907
DY+ D+ ++H ++ G N+C NG CSHLCL P + C CPAHY LN DN TCS
Sbjct: 874 DYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVG---GFVCGCPAHYSLNADNRTCS 930
Query: 908 EPEEFLLFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIR 967
P FLLF+QK+A+ R+++ + D +P+ L+NVRAI+YDP++KQLYW+D + IR
Sbjct: 931 APTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIR 990
Query: 968 RVPISYXXXXXXXXXXXXXXGLS-RPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTG 1026
+ L +PY + +D+ R +YWTC + IN T +D S G
Sbjct: 991 KAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGR-SVG 1049
Query: 1027 VIVRGDRMLPRHLAFHQTKRYLIWNDVGRGA--IMRANVDGTGRVEL--ARADNATALAL 1082
V+++G++ PR + + K Y+ + ++ + I RA +DGT R L + ALAL
Sbjct: 1050 VVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALAL 1109
Query: 1083 DQSAGTVYWAVS 1094
D G ++WA S
Sbjct: 1110 DSRLGKLFWADS 1121
Score = 555 bits (1370), Expect = e-157
Identities = 321/924 (34%), Positives = 494/924 (53%), Gaps = 37/924 (4%)
Query: 2 VNTSRLTRITTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSE 61
++T T I +D+ A+D+ + I W+D + I+ + + G +F +V+
Sbjct: 344 LDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGS--GSQF-VVTA 400
Query: 62 GLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLM 121
+ P GIA+DW LYWTD T++IEV + RK+L +++ RAI + P G M
Sbjct: 401 QIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYM 460
Query: 122 FWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVID 181
+WTDWGEIPKIERA ++G + R V+V ++ WPNG+ +DY+ IYW DAK ++V++
Sbjct: 461 YWTDWGEIPKIERAALDG--SDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMN 518
Query: 182 FNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPA 241
+G R+ +V+ + + F T D +YWTDWQ SI + + + +I P
Sbjct: 519 TDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIER--VHKRSAEREVIIDQLPDLM 576
Query: 242 DIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDS 301
+K + R I S PC + N GCSHLCL P G CACP G +L + T
Sbjct: 577 GLKATNVHRVIGSN---PCAEENGGCSHLCLYRPQ--GLRCACPIGFELISDMKTCIV-- 629
Query: 302 PQMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISK 361
P+ L+ ++R+ I +ISL++ + +PL +K +DFD IYW D KTIS+
Sbjct: 630 PEAFLLFSRRADIRRISLETNN-NNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISR 688
Query: 362 ARLDGSD-QSVVVRSSGVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELY 420
A ++GS + VV P+ +A+D L + +YW D + I V++LDG + +V++ +L
Sbjct: 689 AFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLD 748
Query: 421 DPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLY 480
PRA+AL G+M+W++W K PKI+RA +DGS R L+ + N + +D +LY
Sbjct: 749 SPRALALDPAEGFMYWTEWGGK-PKIDRAAMDGSERTTLVPN-VGRANGLTIDYAKRRLY 806
Query: 481 WGDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLD 540
W D T+ IE NM G R E+ ++D+ H FG +R+++R NK +G +
Sbjct: 807 WTDLDTNLIESSNMLGLNR-EVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQN 865
Query: 541 RQPVVEQMANMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRP-DDYICGCPLGLELTAD 599
R + + +M + F GWN CA NG CSHLC P ++CGCP L AD
Sbjct: 866 RTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNAD 925
Query: 600 KKTCVEPEAFLVYSRKNIIGRLSIKNEYN-DAVIPIKDLKEVSALALYVSGSKLYWSDSK 658
+TC P FL++S+K+ I R+ I + + D ++PI L+ V A+ +LYW DS+
Sbjct: 926 NRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSR 985
Query: 659 TKTINRCSVNGSAVEKIV------EWLGLVE-GLAIDWSGQNIYWTDTTTQRIEVSRLDG 711
I + +GS +V + L + L+ID + IYWT T I V+RLDG
Sbjct: 986 QNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDG 1045
Query: 712 SSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS--IKRAAMDGSSVSV-FMEQVGRVH 768
S ++ +P+++V++P+KGYMY++ L +S I+RAA+DG+ V F + +
Sbjct: 1046 RSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPI 1105
Query: 769 ALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLAD-NIPMPYALALFNDSVYWGDWNTG 827
ALA+D ++WA D +E + L+G R L D NI P L +F + +YW D
Sbjct: 1106 ALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQ 1165
Query: 828 QIQQARKTDGSNRKSIRKDLDYISDLKLYHRAKSMGSNQ--CGVDNGGCSHLCLPTPGDV 885
I++ T R ++ + +SD+ Q C DNGGCSH+CL GD
Sbjct: 1166 MIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICL-VKGDG 1224
Query: 886 RTDYRCACPAHYRLNKDNITCSEP 909
T RC+CP H L +D ++C EP
Sbjct: 1225 TT--RCSCPMHLVLLQDELSCGEP 1246
Score = 304 bits (746), Expect = 1e-81
Identities = 168/492 (34%), Positives = 258/492 (52%), Gaps = 18/492 (3%)
Query: 610 LVYSRKNIIGRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNG 669
L+Y+ + + + N +A I + L++ +A+ S +YWSD + I R N
Sbjct: 23 LLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNK 82
Query: 670 SAVEKIVEWLGLV--EGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKS 727
+ + V GL+ +GLA DW G+ +YWTD+ T RIEVS LDGS R+ + WQ L +P++
Sbjct: 83 TESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRA 142
Query: 728 IVLDPKKGYMYWSELGS-KSIKRAAMDGSSVSVFM-EQVGRVHALAIDYERRAIYWAALD 785
I LDP G+MYW++ G I+RA MDGSS + + ++ + L +DYE + +YWA
Sbjct: 143 IALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADAK 202
Query: 786 PPVVEFAFLNGTGRQTLA-DNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIR 844
+ + L+GT RQ + ++P P+AL LF D +YW DW+T I K G + I
Sbjct: 203 LNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIH 262
Query: 845 KDLDYISDLKLYHRAKS-MGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDN 903
D+ D+ + + + +N CG+DNGGCSHLCL +P V+ Y+CACP +L ++
Sbjct: 263 SDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSP--VKPFYQCACPTGVKLLENG 320
Query: 904 ITCSE-PEEFLLFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDD 962
TC + E LL A++ + RI + + D + L +++ AI+YDPVE +YW DD+
Sbjct: 321 KTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDE 380
Query: 963 SHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNN 1022
+IRR I ++ P + +D + R +YWT D I T + N
Sbjct: 381 VRAIRRSFID-----GSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRL-NG 434
Query: 1023 SSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGR-GAIMRANVDGTGRVELARADNA--TA 1079
+ +++ D PR + Y+ W D G I RA +DG+ RV L
Sbjct: 435 TMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNG 494
Query: 1080 LALDQSAGTVYW 1091
LALD G +YW
Sbjct: 495 LALDYDEGKIYW 506
Score = 44.0 bits (99), Expect = 0.003
Identities = 28/92 (30%), Positives = 33/92 (35%), Gaps = 10/92 (10%)
Query: 1093 VSRQCDGQQDCEDGRDEAECGACG-GDVRCADGTXXXXXXXXXXXXXXXXXXXX------ 1145
V+ +CDG +CED DE C C +CA G
Sbjct: 1266 VAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVL 1325
Query: 1146 ---DAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
D FRC G CI CD C+D SDE
Sbjct: 1326 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDE 1357
>BC117136-1|AAI17137.1| 1613|Homo sapiens low density lipoprotein
receptor-related protein 6 protein.
Length = 1613
Score = 1013 bits (2507), Expect = 0.0
Identities = 481/1092 (44%), Positives = 685/1092 (62%), Gaps = 22/1092 (2%)
Query: 11 TTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIA 70
T + LE AVDF + LI WSD E I+ +N+T + + +V GL++P G+A
Sbjct: 44 TIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQN--VVVSGLLSPDGLA 101
Query: 71 IDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIP 130
DW +KLYWTD ETN+IEV ++ RKVLFW E+D RAIA+ P G M+WTDWGE+P
Sbjct: 102 CDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVP 161
Query: 131 KIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRV 190
KIERAGM+G ++R +I+ I+WPNG+T+DY +YW DAKL F+ + +G R+ V
Sbjct: 162 KIERAGMDG--SSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAV 219
Query: 191 VKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESR 250
VKG L +PFALT D LYWTDW SI + G ++E+ P DI + + R
Sbjct: 220 VKGSLPHPFALTLFEDILYWTDWSTHSILACN-KYTGEGLREIHSDIFSPMDIHAFSQQR 278
Query: 251 QIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQ 310
Q + PC +N GCSHLCL+SP P Y CACPTGVKL EN T C D LL++A+
Sbjct: 279 QPNATN--PCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKT-CKDGATELLLLAR 335
Query: 311 RSTISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGS-DQ 369
R+ + +ISLD+PDFT L L+D++ + +D+DP YIYW D + I ++ +DGS Q
Sbjct: 336 RTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQ 395
Query: 370 SVVVRSSGVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHL 429
VV PD IA+D ++R +YWTD D I V RL+G+ K++I +L +PRAI L
Sbjct: 396 FVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDP 455
Query: 430 TAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKI 489
G+M+W+DW E PKIERA LDGS RV+L++ L WPN +ALD K+YWGDA+T KI
Sbjct: 456 MVGYMYWTDWGEI-PKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKI 514
Query: 490 EVCNMDGTERKELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMA 549
EV N DGT R+ L + I HIFG Q+R+++R++K + +R+ +++Q+
Sbjct: 515 EVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSA-EREVIIDQLP 573
Query: 550 NMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAF 609
++MG+KA + +G NPCA++NGGCSHLC RP C CP+G EL +D KTC+ PEAF
Sbjct: 574 DLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTCIVPEAF 633
Query: 610 LVYSRKNIIGRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNG 669
L++SR+ I R+S++ N+ IP+ +KE SAL V+ +++YW+D KTI+R +NG
Sbjct: 634 LLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNG 693
Query: 670 SAVEKIVEW-LGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSI 728
SA+E +VE+ L EG+A+DW G+N+YW DT T RIEVS+LDG R+ ++W+ L P+++
Sbjct: 694 SALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRAL 753
Query: 729 VLDPKKGYMYWSELGSK-SIKRAAMDGSSVSVFMEQVGRVHALAIDYERRAIYWAALDPP 787
LDP +G+MYW+E G K I RAAMDGS + + VGR + L IDY +R +YW LD
Sbjct: 754 ALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTN 813
Query: 788 VVEFAFLNGTGRQTLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDL 847
++E + + G R+ +AD++P P+ L + D +YW DW+ I++A KT G NR I+ L
Sbjct: 814 LIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHL 873
Query: 848 DYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS 907
DY+ D+ ++H ++ G N+C NG CSHLCL P + C CPAHY LN DN TCS
Sbjct: 874 DYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVG---GFVCGCPAHYSLNADNRTCS 930
Query: 908 EPEEFLLFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIR 967
P FLLF+QK+A+ R+++ + D +P+ L+NVRAI+YDP++KQLYW+D + IR
Sbjct: 931 APTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIR 990
Query: 968 RVPISYXXXXXXXXXXXXXXGLS-RPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTG 1026
+ L +PY + +D+ R +YWTC + IN T +D S G
Sbjct: 991 KAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGR-SVG 1049
Query: 1027 VIVRGDRMLPRHLAFHQTKRYLIWNDVGRGA--IMRANVDGTGRVEL--ARADNATALAL 1082
V+++G++ PR + + K Y+ + ++ + I RA +DGT R L + ALAL
Sbjct: 1050 VVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALAL 1109
Query: 1083 DQSAGTVYWAVS 1094
D G ++WA S
Sbjct: 1110 DSRLGKLFWADS 1121
Score = 555 bits (1370), Expect = e-157
Identities = 321/924 (34%), Positives = 494/924 (53%), Gaps = 37/924 (4%)
Query: 2 VNTSRLTRITTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSE 61
++T T I +D+ A+D+ + I W+D + I+ + + G +F +V+
Sbjct: 344 LDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGS--GSQF-VVTA 400
Query: 62 GLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLM 121
+ P GIA+DW LYWTD T++IEV + RK+L +++ RAI + P G M
Sbjct: 401 QIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYM 460
Query: 122 FWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVID 181
+WTDWGEIPKIERA ++G + R V+V ++ WPNG+ +DY+ IYW DAK ++V++
Sbjct: 461 YWTDWGEIPKIERAALDG--SDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMN 518
Query: 182 FNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPA 241
+G R+ +V+ + + F T D +YWTDWQ SI + + + +I P
Sbjct: 519 TDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIER--VHKRSAEREVIIDQLPDLM 576
Query: 242 DIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDS 301
+K + R I S PC + N GCSHLCL P G CACP G +L + T
Sbjct: 577 GLKATNVHRVIGSN---PCAEENGGCSHLCLYRPQ--GLRCACPIGFELISDMKTCIV-- 629
Query: 302 PQMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISK 361
P+ L+ ++R+ I +ISL++ + +PL +K +DFD IYW D KTIS+
Sbjct: 630 PEAFLLFSRRADIRRISLETNN-NNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISR 688
Query: 362 ARLDGSD-QSVVVRSSGVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELY 420
A ++GS + VV P+ +A+D L + +YW D + I V++LDG + +V++ +L
Sbjct: 689 AFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLD 748
Query: 421 DPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLY 480
PRA+AL G+M+W++W K PKI+RA +DGS R L+ + N + +D +LY
Sbjct: 749 SPRALALDPAEGFMYWTEWGGK-PKIDRAAMDGSERTTLVPN-VGRANGLTIDYAKRRLY 806
Query: 481 WGDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLD 540
W D T+ IE NM G R E+ ++D+ H FG +R+++R NK +G +
Sbjct: 807 WTDLDTNLIESSNMLGLNR-EVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQN 865
Query: 541 RQPVVEQMANMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRP-DDYICGCPLGLELTAD 599
R + + +M + F GWN CA NG CSHLC P ++CGCP L AD
Sbjct: 866 RTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNAD 925
Query: 600 KKTCVEPEAFLVYSRKNIIGRLSIKNEYN-DAVIPIKDLKEVSALALYVSGSKLYWSDSK 658
+TC P FL++S+K+ I R+ I + + D ++PI L+ V A+ +LYW DS+
Sbjct: 926 NRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSR 985
Query: 659 TKTINRCSVNGSAVEKIV------EWLGLVE-GLAIDWSGQNIYWTDTTTQRIEVSRLDG 711
I + +GS +V + L + L+ID + IYWT T I V+RLDG
Sbjct: 986 QNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDG 1045
Query: 712 SSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS--IKRAAMDGSSVSV-FMEQVGRVH 768
S ++ +P+++V++P+KGYMY++ L +S I+RAA+DG+ V F + +
Sbjct: 1046 RSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPI 1105
Query: 769 ALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLAD-NIPMPYALALFNDSVYWGDWNTG 827
ALA+D ++WA D +E + L+G R L D NI P L +F + +YW D
Sbjct: 1106 ALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQ 1165
Query: 828 QIQQARKTDGSNRKSIRKDLDYISDLKLYHRAKSMGSNQ--CGVDNGGCSHLCLPTPGDV 885
I++ T R ++ + +SD+ Q C DNGGCSH+CL GD
Sbjct: 1166 MIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICL-VKGDG 1224
Query: 886 RTDYRCACPAHYRLNKDNITCSEP 909
T RC+CP H L +D ++C EP
Sbjct: 1225 TT--RCSCPMHLVLLQDELSCGEP 1246
Score = 304 bits (746), Expect = 1e-81
Identities = 168/492 (34%), Positives = 258/492 (52%), Gaps = 18/492 (3%)
Query: 610 LVYSRKNIIGRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNG 669
L+Y+ + + + N +A I + L++ +A+ S +YWSD + I R N
Sbjct: 23 LLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNK 82
Query: 670 SAVEKIVEWLGLV--EGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKS 727
+ + V GL+ +GLA DW G+ +YWTD+ T RIEVS LDGS R+ + WQ L +P++
Sbjct: 83 TESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRA 142
Query: 728 IVLDPKKGYMYWSELGS-KSIKRAAMDGSSVSVFM-EQVGRVHALAIDYERRAIYWAALD 785
I LDP G+MYW++ G I+RA MDGSS + + ++ + L +DYE + +YWA
Sbjct: 143 IALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADAK 202
Query: 786 PPVVEFAFLNGTGRQTLA-DNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIR 844
+ + L+GT RQ + ++P P+AL LF D +YW DW+T I K G + I
Sbjct: 203 LNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIH 262
Query: 845 KDLDYISDLKLYHRAKS-MGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDN 903
D+ D+ + + + +N CG+DNGGCSHLCL +P V+ Y+CACP +L ++
Sbjct: 263 SDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSP--VKPFYQCACPTGVKLLENG 320
Query: 904 ITCSE-PEEFLLFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDD 962
TC + E LL A++ + RI + + D + L +++ AI+YDPVE +YW DD+
Sbjct: 321 KTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDE 380
Query: 963 SHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNN 1022
+IRR I ++ P + +D + R +YWT D I T + N
Sbjct: 381 VRAIRRSFID-----GSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRL-NG 434
Query: 1023 SSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGR-GAIMRANVDGTGRVELARADNA--TA 1079
+ +++ D PR + Y+ W D G I RA +DG+ RV L
Sbjct: 435 TMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNG 494
Query: 1080 LALDQSAGTVYW 1091
LALD G +YW
Sbjct: 495 LALDYDEGKIYW 506
Score = 44.0 bits (99), Expect = 0.003
Identities = 28/92 (30%), Positives = 33/92 (35%), Gaps = 10/92 (10%)
Query: 1093 VSRQCDGQQDCEDGRDEAECGACG-GDVRCADGTXXXXXXXXXXXXXXXXXXXX------ 1145
V+ +CDG +CED DE C C +CA G
Sbjct: 1266 VAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVL 1325
Query: 1146 ---DAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
D FRC G CI CD C+D SDE
Sbjct: 1326 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDE 1357
>AF283321-1|AAK52433.1| 1611|Homo sapiens low density lipoprotein
receptor-related protein 5 protein.
Length = 1611
Score = 981 bits (2429), Expect = 0.0
Identities = 469/1088 (43%), Positives = 681/1088 (62%), Gaps = 22/1088 (2%)
Query: 11 TTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIA 70
T + LE AVDF + K + W+D E I+ N+T + ++S GLV+P G+A
Sbjct: 56 TIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVIS-GLVSPDGLA 114
Query: 71 IDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIP 130
DW KLYWTD ETN+IEV ++ RKVLFW ++D RAIA+ P G M+WTDWGE P
Sbjct: 115 CDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETP 174
Query: 131 KIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRV 190
+IERAGM+G +TRK+IV +I+WPNG+T+D +YW DAKL F+ + +G R++V
Sbjct: 175 RIERAGMDG--STRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKV 232
Query: 191 VKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESR 250
V+G L +PFALT S D LYWTDWQ SI+ + G K KE++ + P DI+V + R
Sbjct: 233 VEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGG-KRKEILSALYSPMDIQVLSQER 291
Query: 251 QIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQ 310
Q C+++N GCSHLCLLSP P Y CACPTGV+L++N T C + +L++A+
Sbjct: 292 QPFFHTR--CEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRT-CKAGAEEVLLLAR 348
Query: 311 RSTISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQS 370
R+ + +ISLD+PDFT L + D++ + +D+DP Y+YW D + I +A LDGS
Sbjct: 349 RTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQ 408
Query: 371 VVVRSS-GVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHL 429
+V + PD IA+D ++R +YWTD D I V RL+G+ K+++ +L +PRAIALH
Sbjct: 409 TLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHP 468
Query: 430 TAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKI 489
G M+W+DW E PKIE ANLDG R +L++ L WPN +ALD KLYWGDA+T KI
Sbjct: 469 VMGLMYWTDWGEN-PKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKI 527
Query: 490 EVCNMDGTERKELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMA 549
EV N+DGT+R+ L + + HIFG Q+R+++R++K R +++Q+
Sbjct: 528 EVINVDGTKRRTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHK-VKASRDVIIDQLP 586
Query: 550 NMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAF 609
++MG+KA + +G NPCAD NGGCSHLCF P CGCP+GLEL +D KTC+ PEAF
Sbjct: 587 DLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTCIVPEAF 646
Query: 610 LVYSRKNIIGRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNG 669
LV++ + I R+S++ ND IP+ +KE SAL VS + +YW+D KTI+R +NG
Sbjct: 647 LVFTSRAAIHRISLETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNG 706
Query: 670 SAVEKIVEW-LGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSI 728
S+VE +VE+ L EG+A+DW G+N+YW DT T RIEV+RLDG R+ ++W+ L P+S+
Sbjct: 707 SSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSL 766
Query: 729 VLDPKKGYMYWSELGSK-SIKRAAMDGSSVSVFMEQVGRVHALAIDYERRAIYWAALDPP 787
LDP KGY+YW+E G K I RA MDG++ +++VGR + L IDY + +YW LD
Sbjct: 767 ALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTN 826
Query: 788 VVEFAFLNGTGRQTLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDL 847
++E + + G R +AD++P P+ L ++D +YW DWN I++A KT G NR I+ L
Sbjct: 827 MIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHL 886
Query: 848 DYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS 907
D++ D+ ++H ++ G N C +NG C LCL PG +RC C +HY L+ + CS
Sbjct: 887 DFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPG----GHRCGCASHYTLDPSSRNCS 942
Query: 908 EPEEFLLFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIR 967
P FLLF+QK+A+ R++ + D +PL GL+NV+AI+YDP++K +YW+ D +I+
Sbjct: 943 PPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWV-DGRQNIK 1001
Query: 968 RVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGV 1027
R +P+ + +D+ RT++WTC ++IN + + + GV
Sbjct: 1002 RAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRL-SGEAMGV 1060
Query: 1028 IVRGDRMLPRHLAFHQTKRYLIWNDV-GRGA-IMRANVDGTGRVELARAD--NATALALD 1083
++RGDR PR + + + YL + ++ R A I RA +DGT R L AL +D
Sbjct: 1061 VLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVD 1120
Query: 1084 QSAGTVYW 1091
+ G ++W
Sbjct: 1121 NTLGKLFW 1128
Score = 495 bits (1222), Expect = e-139
Identities = 287/922 (31%), Positives = 475/922 (51%), Gaps = 36/922 (3%)
Query: 2 VNTSRLTRITTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSE 61
++T T I D+ A+D+ + + W+D + I+ + + G + +V+
Sbjct: 357 LDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGS--GAQ-TLVNT 413
Query: 62 GLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLM 121
+ P GIA+DW LYWTD T++IEV + RK+L ++D RAIA+ P GLM
Sbjct: 414 EINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLM 473
Query: 122 FWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVID 181
+WTDWGE PKIE A ++G R+V+V ++ WPNG+ +D +YW DAK ++VI+
Sbjct: 474 YWTDWGENPKIECANLDGQE--RRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVIN 531
Query: 182 FNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPA 241
+G KR+ +++ L + F T D +YWTDWQ SI + +I P
Sbjct: 532 VDGTKRRTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDV--IIDQLPDLM 589
Query: 242 DIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDS 301
+K + ++ ++ PC N GCSHLC +P C CP G++L + T
Sbjct: 590 GLKAVNVAK-VVGTN--PCADRNGGCSHLCFFTPHAT--RCGCPIGLELLSDMKTCIV-- 642
Query: 302 PQMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISK 361
P+ LV R+ I +ISL++ + +PL +K +DFD +IYW D KTIS+
Sbjct: 643 PEAFLVFTSRAAIHRISLETNN-NDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISR 701
Query: 362 ARLDGSD-QSVVVRSSGVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELY 420
A ++GS + VV P+ +A+D + + +YW D + I VARLDG + +V++ +L
Sbjct: 702 AFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLD 761
Query: 421 DPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLY 480
+PR++AL T G+++W++W K P+I RA +DG+ + L+ +K+ N + +D + +LY
Sbjct: 762 NPRSLALDPTKGYIYWTEWGGK-PRIVRAFMDGTNCMTLV-DKVGRANDLTIDYADQRLY 819
Query: 481 WGDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLD 540
W D T+ IE NM G ER + ++D+ H FG +++R +K +G +
Sbjct: 820 WTDLDTNMIESSNMLGQERVVI-ADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRN 878
Query: 541 RQPVVEQMANMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADK 600
R + + +M + F G N C +NG C LC P + CGC L
Sbjct: 879 RTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSS 938
Query: 601 KTCVEPEAFLVYSRKNIIGRLSIKNEYN-DAVIPIKDLKEVSALALYVSGSKLYWSDSKT 659
+ C P FL++S+K+ I R+ ++++ D ++P+ L+ V A+ +YW D +
Sbjct: 939 RNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGR- 997
Query: 660 KTINRCSVNGS---AVEKIVEWLG---LVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSS 713
+ I R +G+ + + + L+ID + ++WT T I V RL G +
Sbjct: 998 QNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEA 1057
Query: 714 RRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS--IKRAAMDGSSVSV-FMEQVGRVHAL 770
++ KP++IV++ ++GY+Y++ + ++ I+RAA+DG+ V F + R AL
Sbjct: 1058 MGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVAL 1117
Query: 771 AIDYERRAIYWAALDPPVVEFAFLNGTGRQTLAD-NIPMPYALALFNDSVYWGDWNTGQI 829
+D ++W D +E L+G R TL D NI P L + +YW D I
Sbjct: 1118 VVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMI 1177
Query: 830 QQARKTDGSNRKSIRKDLDYISDLKLYHRA--KSMGSNQCGVDNGGCSHLCLPTPGDVRT 887
++ KT G R I+ + +++ + + ++ C DNGGCSH+C+ GD
Sbjct: 1178 ERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICI-AKGDGTP 1236
Query: 888 DYRCACPAHYRLNKDNITCSEP 909
RC+CP H L ++ +TC EP
Sbjct: 1237 --RCSCPVHLVLLQNLLTCGEP 1256
Score = 70.5 bits (165), Expect = 3e-11
Identities = 49/183 (26%), Positives = 86/183 (46%), Gaps = 8/183 (4%)
Query: 913 LLFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPIS 972
LLFA + V R++ A G ++ I ++GL++ A+++ + +YW D +I++ +
Sbjct: 35 LLFANRRDV-RLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQ---T 90
Query: 973 YXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGD 1032
Y GL P + D +G+ +YWT ++ + I ++ N +S V+ D
Sbjct: 91 YLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANL-NGTSRKVLFWQD 149
Query: 1033 RMLPRHLAFHQTKRYLIWNDVGR-GAIMRANVDGTGRVELARADN--ATALALDQSAGTV 1089
PR +A Y+ W D G I RA +DG+ R + +D L +D +
Sbjct: 150 LDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKL 209
Query: 1090 YWA 1092
YWA
Sbjct: 210 YWA 212
Score = 66.5 bits (155), Expect = 5e-10
Identities = 33/97 (34%), Positives = 53/97 (54%)
Query: 411 EKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSI 470
E I+ + L D A+ + G ++W+D +E+ K N G+ ++ L P+ +
Sbjct: 54 ESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGL 113
Query: 471 ALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDI 507
A D V KLYW D+ T++IEV N++GT RK L D+
Sbjct: 114 ACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDL 150
Score = 43.2 bits (97), Expect = 0.006
Identities = 28/89 (31%), Positives = 33/89 (37%), Gaps = 10/89 (11%)
Query: 1096 QCDGQQDCEDGRDEAECGACGG-DVRCADGTXXXXXXXXXXXXX---XXXXXXXDA---- 1147
+CDG +C+D DE C C CA G DA
Sbjct: 1279 RCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLP 1338
Query: 1148 --FRCDEGLCIAARFVCDGRPQCADGSDE 1174
FRC G C+ + CD P C DGSDE
Sbjct: 1339 NQFRCASGQCVLIKQQCDSFPDCIDGSDE 1367
Score = 35.1 bits (77), Expect = 1.5
Identities = 14/28 (50%), Positives = 15/28 (53%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEA 1175
F C G C+ R CDG C D SDEA
Sbjct: 1303 FPCARGQCVDLRLRCDGEADCQDRSDEA 1330
>AF077820-1|AAC72791.1| 1615|Homo sapiens LDL receptor member LR3
protein.
Length = 1615
Score = 981 bits (2429), Expect = 0.0
Identities = 469/1088 (43%), Positives = 681/1088 (62%), Gaps = 22/1088 (2%)
Query: 11 TTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIA 70
T + LE AVDF + K + W+D E I+ N+T + ++S GLV+P G+A
Sbjct: 56 TIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVIS-GLVSPDGLA 114
Query: 71 IDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIP 130
DW KLYWTD ETN+IEV ++ RKVLFW ++D RAIA+ P G M+WTDWGE P
Sbjct: 115 CDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETP 174
Query: 131 KIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRV 190
+IERAGM+G +TRK+IV +I+WPNG+T+D +YW DAKL F+ + +G R++V
Sbjct: 175 RIERAGMDG--STRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKV 232
Query: 191 VKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESR 250
V+G L +PFALT S D LYWTDWQ SI+ + G K KE++ + P DI+V + R
Sbjct: 233 VEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGG-KRKEILSALYSPMDIQVLSQER 291
Query: 251 QIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQ 310
Q C+++N GCSHLCLLSP P Y CACPTGV+L++N T C + +L++A+
Sbjct: 292 QPFFHTR--CEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRT-CKAGAEEVLLLAR 348
Query: 311 RSTISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQS 370
R+ + +ISLD+PDFT L + D++ + +D+DP Y+YW D + I +A LDGS
Sbjct: 349 RTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQ 408
Query: 371 VVVRSS-GVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHL 429
+V + PD IA+D ++R +YWTD D I V RL+G+ K+++ +L +PRAIALH
Sbjct: 409 TLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHP 468
Query: 430 TAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKI 489
G M+W+DW E PKIE ANLDG R +L++ L WPN +ALD KLYWGDA+T KI
Sbjct: 469 VMGLMYWTDWGEN-PKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKI 527
Query: 490 EVCNMDGTERKELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMA 549
EV N+DGT+R+ L + + HIFG Q+R+++R++K R +++Q+
Sbjct: 528 EVINVDGTKRRTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHK-VKASRDVIIDQLP 586
Query: 550 NMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAF 609
++MG+KA + +G NPCAD NGGCSHLCF P CGCP+GLEL +D KTC+ PEAF
Sbjct: 587 DLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTCIVPEAF 646
Query: 610 LVYSRKNIIGRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNG 669
LV++ + I R+S++ ND IP+ +KE SAL VS + +YW+D KTI+R +NG
Sbjct: 647 LVFTSRAAIHRISLETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNG 706
Query: 670 SAVEKIVEW-LGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSI 728
S+VE +VE+ L EG+A+DW G+N+YW DT T RIEV+RLDG R+ ++W+ L P+S+
Sbjct: 707 SSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSL 766
Query: 729 VLDPKKGYMYWSELGSK-SIKRAAMDGSSVSVFMEQVGRVHALAIDYERRAIYWAALDPP 787
LDP KGY+YW+E G K I RA MDG++ +++VGR + L IDY + +YW LD
Sbjct: 767 ALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTN 826
Query: 788 VVEFAFLNGTGRQTLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDL 847
++E + + G R +AD++P P+ L ++D +YW DWN I++A KT G NR I+ L
Sbjct: 827 MIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHL 886
Query: 848 DYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS 907
D++ D+ ++H ++ G N C +NG C LCL PG +RC C +HY L+ + CS
Sbjct: 887 DFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPG----GHRCGCASHYTLDPSSRNCS 942
Query: 908 EPEEFLLFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIR 967
P FLLF+QK+A+ R++ + D +PL GL+NV+AI+YDP++K +YW+ D +I+
Sbjct: 943 PPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWV-DGRQNIK 1001
Query: 968 RVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGV 1027
R +P+ + +D+ RT++WTC ++IN + + + GV
Sbjct: 1002 RAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRL-SGEAMGV 1060
Query: 1028 IVRGDRMLPRHLAFHQTKRYLIWNDV-GRGA-IMRANVDGTGRVELARAD--NATALALD 1083
++RGDR PR + + + YL + ++ R A I RA +DGT R L AL +D
Sbjct: 1061 VLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVD 1120
Query: 1084 QSAGTVYW 1091
+ G ++W
Sbjct: 1121 NTLGKLFW 1128
Score = 495 bits (1222), Expect = e-139
Identities = 287/922 (31%), Positives = 475/922 (51%), Gaps = 36/922 (3%)
Query: 2 VNTSRLTRITTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSE 61
++T T I D+ A+D+ + + W+D + I+ + + G + +V+
Sbjct: 357 LDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGS--GAQ-TLVNT 413
Query: 62 GLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLM 121
+ P GIA+DW LYWTD T++IEV + RK+L ++D RAIA+ P GLM
Sbjct: 414 EINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLM 473
Query: 122 FWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVID 181
+WTDWGE PKIE A ++G R+V+V ++ WPNG+ +D +YW DAK ++VI+
Sbjct: 474 YWTDWGENPKIECANLDGQE--RRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVIN 531
Query: 182 FNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPA 241
+G KR+ +++ L + F T D +YWTDWQ SI + +I P
Sbjct: 532 VDGTKRRTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDV--IIDQLPDLM 589
Query: 242 DIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDS 301
+K + ++ ++ PC N GCSHLC +P C CP G++L + T
Sbjct: 590 GLKAVNVAK-VVGTN--PCADRNGGCSHLCFFTPHAT--RCGCPIGLELLSDMKTCIV-- 642
Query: 302 PQMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISK 361
P+ LV R+ I +ISL++ + +PL +K +DFD +IYW D KTIS+
Sbjct: 643 PEAFLVFTSRAAIHRISLETNN-NDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISR 701
Query: 362 ARLDGSD-QSVVVRSSGVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELY 420
A ++GS + VV P+ +A+D + + +YW D + I VARLDG + +V++ +L
Sbjct: 702 AFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLD 761
Query: 421 DPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLY 480
+PR++AL T G+++W++W K P+I RA +DG+ + L+ +K+ N + +D + +LY
Sbjct: 762 NPRSLALDPTKGYIYWTEWGGK-PRIVRAFMDGTNCMTLV-DKVGRANDLTIDYADQRLY 819
Query: 481 WGDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLD 540
W D T+ IE NM G ER + ++D+ H FG +++R +K +G +
Sbjct: 820 WTDLDTNMIESSNMLGQERVVI-ADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRN 878
Query: 541 RQPVVEQMANMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADK 600
R + + +M + F G N C +NG C LC P + CGC L
Sbjct: 879 RTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSS 938
Query: 601 KTCVEPEAFLVYSRKNIIGRLSIKNEYN-DAVIPIKDLKEVSALALYVSGSKLYWSDSKT 659
+ C P FL++S+K+ I R+ ++++ D ++P+ L+ V A+ +YW D +
Sbjct: 939 RNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGR- 997
Query: 660 KTINRCSVNGS---AVEKIVEWLG---LVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSS 713
+ I R +G+ + + + L+ID + ++WT T I V RL G +
Sbjct: 998 QNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEA 1057
Query: 714 RRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS--IKRAAMDGSSVSV-FMEQVGRVHAL 770
++ KP++IV++ ++GY+Y++ + ++ I+RAA+DG+ V F + R AL
Sbjct: 1058 MGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVAL 1117
Query: 771 AIDYERRAIYWAALDPPVVEFAFLNGTGRQTLAD-NIPMPYALALFNDSVYWGDWNTGQI 829
+D ++W D +E L+G R TL D NI P L + +YW D I
Sbjct: 1118 VVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMI 1177
Query: 830 QQARKTDGSNRKSIRKDLDYISDLKLYHRA--KSMGSNQCGVDNGGCSHLCLPTPGDVRT 887
++ KT G R I+ + +++ + + ++ C DNGGCSH+C+ GD
Sbjct: 1178 ERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICI-AKGDGTP 1236
Query: 888 DYRCACPAHYRLNKDNITCSEP 909
RC+CP H L ++ +TC EP
Sbjct: 1237 --RCSCPVHLVLLQNLLTCGEP 1256
Score = 70.5 bits (165), Expect = 3e-11
Identities = 49/183 (26%), Positives = 86/183 (46%), Gaps = 8/183 (4%)
Query: 913 LLFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPIS 972
LLFA + V R++ A G ++ I ++GL++ A+++ + +YW D +I++ +
Sbjct: 35 LLFANRRDV-RLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQ---T 90
Query: 973 YXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGD 1032
Y GL P + D +G+ +YWT ++ + I ++ N +S V+ D
Sbjct: 91 YLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANL-NGTSRKVLFWQD 149
Query: 1033 RMLPRHLAFHQTKRYLIWNDVGR-GAIMRANVDGTGRVELARADN--ATALALDQSAGTV 1089
PR +A Y+ W D G I RA +DG+ R + +D L +D +
Sbjct: 150 LDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKL 209
Query: 1090 YWA 1092
YWA
Sbjct: 210 YWA 212
Score = 66.5 bits (155), Expect = 5e-10
Identities = 33/97 (34%), Positives = 53/97 (54%)
Query: 411 EKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSI 470
E I+ + L D A+ + G ++W+D +E+ K N G+ ++ L P+ +
Sbjct: 54 ESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGL 113
Query: 471 ALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDI 507
A D V KLYW D+ T++IEV N++GT RK L D+
Sbjct: 114 ACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDL 150
Score = 43.2 bits (97), Expect = 0.006
Identities = 28/89 (31%), Positives = 33/89 (37%), Gaps = 10/89 (11%)
Query: 1096 QCDGQQDCEDGRDEAECGACGG-DVRCADGTXXXXXXXXXXXXX---XXXXXXXDA---- 1147
+CDG +C+D DE C C CA G DA
Sbjct: 1279 RCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLP 1338
Query: 1148 --FRCDEGLCIAARFVCDGRPQCADGSDE 1174
FRC G C+ + CD P C DGSDE
Sbjct: 1339 NQFRCASGQCVLIKQQCDSFPDCIDGSDE 1367
Score = 35.1 bits (77), Expect = 1.5
Identities = 14/28 (50%), Positives = 15/28 (53%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEA 1175
F C G C+ R CDG C D SDEA
Sbjct: 1303 FPCARGQCVDLRLRCDGEADCQDRSDEA 1330
>AF064548-1|AAC36467.1| 1615|Homo sapiens low-density lipoprotein
receptor-related protein 5 protein.
Length = 1615
Score = 981 bits (2429), Expect = 0.0
Identities = 469/1088 (43%), Positives = 681/1088 (62%), Gaps = 22/1088 (2%)
Query: 11 TTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIA 70
T + LE AVDF + K + W+D E I+ N+T + ++S GLV+P G+A
Sbjct: 56 TIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVIS-GLVSPDGLA 114
Query: 71 IDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIP 130
DW KLYWTD ETN+IEV ++ RKVLFW ++D RAIA+ P G M+WTDWGE P
Sbjct: 115 CDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETP 174
Query: 131 KIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRV 190
+IERAGM+G +TRK+IV +I+WPNG+T+D +YW DAKL F+ + +G R++V
Sbjct: 175 RIERAGMDG--STRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKV 232
Query: 191 VKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESR 250
V+G L +PFALT S D LYWTDWQ SI+ + G K KE++ + P DI+V + R
Sbjct: 233 VEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGG-KRKEILSALYSPMDIQVLSQER 291
Query: 251 QIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQ 310
Q C+++N GCSHLCLLSP P Y CACPTGV+L++N T C + +L++A+
Sbjct: 292 QPFFHTR--CEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRT-CKAGAEEVLLLAR 348
Query: 311 RSTISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQS 370
R+ + +ISLD+PDFT L + D++ + +D+DP Y+YW D + I +A LDGS
Sbjct: 349 RTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQ 408
Query: 371 VVVRSS-GVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHL 429
+V + PD IA+D ++R +YWTD D I V RL+G+ K+++ +L +PRAIALH
Sbjct: 409 TLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHP 468
Query: 430 TAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKI 489
G M+W+DW E PKIE ANLDG R +L++ L WPN +ALD KLYWGDA+T KI
Sbjct: 469 VMGLMYWTDWGEN-PKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKI 527
Query: 490 EVCNMDGTERKELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMA 549
EV N+DGT+R+ L + + HIFG Q+R+++R++K R +++Q+
Sbjct: 528 EVINVDGTKRRTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHK-VKASRDVIIDQLP 586
Query: 550 NMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAF 609
++MG+KA + +G NPCAD NGGCSHLCF P CGCP+GLEL +D KTC+ PEAF
Sbjct: 587 DLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTCIVPEAF 646
Query: 610 LVYSRKNIIGRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNG 669
LV++ + I R+S++ ND IP+ +KE SAL VS + +YW+D KTI+R +NG
Sbjct: 647 LVFTSRAAIHRISLETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNG 706
Query: 670 SAVEKIVEW-LGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSI 728
S+VE +VE+ L EG+A+DW G+N+YW DT T RIEV+RLDG R+ ++W+ L P+S+
Sbjct: 707 SSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSL 766
Query: 729 VLDPKKGYMYWSELGSK-SIKRAAMDGSSVSVFMEQVGRVHALAIDYERRAIYWAALDPP 787
LDP KGY+YW+E G K I RA MDG++ +++VGR + L IDY + +YW LD
Sbjct: 767 ALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTN 826
Query: 788 VVEFAFLNGTGRQTLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDL 847
++E + + G R +AD++P P+ L ++D +YW DWN I++A KT G NR I+ L
Sbjct: 827 MIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHL 886
Query: 848 DYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS 907
D++ D+ ++H ++ G N C +NG C LCL PG +RC C +HY L+ + CS
Sbjct: 887 DFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPG----GHRCGCASHYTLDPSSRNCS 942
Query: 908 EPEEFLLFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIR 967
P FLLF+QK+A+ R++ + D +PL GL+NV+AI+YDP++K +YW+ D +I+
Sbjct: 943 PPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWV-DGRQNIK 1001
Query: 968 RVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGV 1027
R +P+ + +D+ RT++WTC ++IN + + + GV
Sbjct: 1002 RAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRL-SGEAMGV 1060
Query: 1028 IVRGDRMLPRHLAFHQTKRYLIWNDV-GRGA-IMRANVDGTGRVELARAD--NATALALD 1083
++RGDR PR + + + YL + ++ R A I RA +DGT R L AL +D
Sbjct: 1061 VLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVD 1120
Query: 1084 QSAGTVYW 1091
+ G ++W
Sbjct: 1121 NTLGKLFW 1128
Score = 495 bits (1222), Expect = e-139
Identities = 287/922 (31%), Positives = 475/922 (51%), Gaps = 36/922 (3%)
Query: 2 VNTSRLTRITTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSE 61
++T T I D+ A+D+ + + W+D + I+ + + G + +V+
Sbjct: 357 LDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGS--GAQ-TLVNT 413
Query: 62 GLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLM 121
+ P GIA+DW LYWTD T++IEV + RK+L ++D RAIA+ P GLM
Sbjct: 414 EINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLM 473
Query: 122 FWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVID 181
+WTDWGE PKIE A ++G R+V+V ++ WPNG+ +D +YW DAK ++VI+
Sbjct: 474 YWTDWGENPKIECANLDGQE--RRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVIN 531
Query: 182 FNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPA 241
+G KR+ +++ L + F T D +YWTDWQ SI + +I P
Sbjct: 532 VDGTKRRTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDV--IIDQLPDLM 589
Query: 242 DIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDS 301
+K + ++ ++ PC N GCSHLC +P C CP G++L + T
Sbjct: 590 GLKAVNVAK-VVGTN--PCADRNGGCSHLCFFTPHAT--RCGCPIGLELLSDMKTCIV-- 642
Query: 302 PQMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISK 361
P+ LV R+ I +ISL++ + +PL +K +DFD +IYW D KTIS+
Sbjct: 643 PEAFLVFTSRAAIHRISLETNN-NDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISR 701
Query: 362 ARLDGSD-QSVVVRSSGVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELY 420
A ++GS + VV P+ +A+D + + +YW D + I VARLDG + +V++ +L
Sbjct: 702 AFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLD 761
Query: 421 DPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLY 480
+PR++AL T G+++W++W K P+I RA +DG+ + L+ +K+ N + +D + +LY
Sbjct: 762 NPRSLALDPTKGYIYWTEWGGK-PRIVRAFMDGTNCMTLV-DKVGRANDLTIDYADQRLY 819
Query: 481 WGDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLD 540
W D T+ IE NM G ER + ++D+ H FG +++R +K +G +
Sbjct: 820 WTDLDTNMIESSNMLGQERVVI-ADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRN 878
Query: 541 RQPVVEQMANMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADK 600
R + + +M + F G N C +NG C LC P + CGC L
Sbjct: 879 RTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSS 938
Query: 601 KTCVEPEAFLVYSRKNIIGRLSIKNEYN-DAVIPIKDLKEVSALALYVSGSKLYWSDSKT 659
+ C P FL++S+K+ I R+ ++++ D ++P+ L+ V A+ +YW D +
Sbjct: 939 RNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGR- 997
Query: 660 KTINRCSVNGS---AVEKIVEWLG---LVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSS 713
+ I R +G+ + + + L+ID + ++WT T I V RL G +
Sbjct: 998 QNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEA 1057
Query: 714 RRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS--IKRAAMDGSSVSV-FMEQVGRVHAL 770
++ KP++IV++ ++GY+Y++ + ++ I+RAA+DG+ V F + R AL
Sbjct: 1058 MGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVAL 1117
Query: 771 AIDYERRAIYWAALDPPVVEFAFLNGTGRQTLAD-NIPMPYALALFNDSVYWGDWNTGQI 829
+D ++W D +E L+G R TL D NI P L + +YW D I
Sbjct: 1118 VVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMI 1177
Query: 830 QQARKTDGSNRKSIRKDLDYISDLKLYHRA--KSMGSNQCGVDNGGCSHLCLPTPGDVRT 887
++ KT G R I+ + +++ + + ++ C DNGGCSH+C+ GD
Sbjct: 1178 ERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICI-AKGDGTP 1236
Query: 888 DYRCACPAHYRLNKDNITCSEP 909
RC+CP H L ++ +TC EP
Sbjct: 1237 --RCSCPVHLVLLQNLLTCGEP 1256
Score = 70.5 bits (165), Expect = 3e-11
Identities = 49/183 (26%), Positives = 86/183 (46%), Gaps = 8/183 (4%)
Query: 913 LLFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPIS 972
LLFA + V R++ A G ++ I ++GL++ A+++ + +YW D +I++ +
Sbjct: 35 LLFANRRDV-RLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQ---T 90
Query: 973 YXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGD 1032
Y GL P + D +G+ +YWT ++ + I ++ N +S V+ D
Sbjct: 91 YLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANL-NGTSRKVLFWQD 149
Query: 1033 RMLPRHLAFHQTKRYLIWNDVGR-GAIMRANVDGTGRVELARADN--ATALALDQSAGTV 1089
PR +A Y+ W D G I RA +DG+ R + +D L +D +
Sbjct: 150 LDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKL 209
Query: 1090 YWA 1092
YWA
Sbjct: 210 YWA 212
Score = 66.5 bits (155), Expect = 5e-10
Identities = 33/97 (34%), Positives = 53/97 (54%)
Query: 411 EKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSI 470
E I+ + L D A+ + G ++W+D +E+ K N G+ ++ L P+ +
Sbjct: 54 ESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGL 113
Query: 471 ALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDI 507
A D V KLYW D+ T++IEV N++GT RK L D+
Sbjct: 114 ACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDL 150
Score = 43.2 bits (97), Expect = 0.006
Identities = 28/89 (31%), Positives = 33/89 (37%), Gaps = 10/89 (11%)
Query: 1096 QCDGQQDCEDGRDEAECGACGG-DVRCADGTXXXXXXXXXXXXX---XXXXXXXDA---- 1147
+CDG +C+D DE C C CA G DA
Sbjct: 1279 RCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLP 1338
Query: 1148 --FRCDEGLCIAARFVCDGRPQCADGSDE 1174
FRC G C+ + CD P C DGSDE
Sbjct: 1339 NQFRCASGQCVLIKQQCDSFPDCIDGSDE 1367
Score = 35.1 bits (77), Expect = 1.5
Identities = 14/28 (50%), Positives = 15/28 (53%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEA 1175
F C G C+ R CDG C D SDEA
Sbjct: 1303 FPCARGQCVDLRLRCDGEADCQDRSDEA 1330
>AB017498-1|BAA33051.1| 1615|Homo sapiens Lipoprotein Receptor Related
Protein 5 protein.
Length = 1615
Score = 981 bits (2429), Expect = 0.0
Identities = 469/1088 (43%), Positives = 681/1088 (62%), Gaps = 22/1088 (2%)
Query: 11 TTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIA 70
T + LE AVDF + K + W+D E I+ N+T + ++S GLV+P G+A
Sbjct: 56 TIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVIS-GLVSPDGLA 114
Query: 71 IDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIP 130
DW KLYWTD ETN+IEV ++ RKVLFW ++D RAIA+ P G M+WTDWGE P
Sbjct: 115 CDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETP 174
Query: 131 KIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRV 190
+IERAGM+G +TRK+IV +I+WPNG+T+D +YW DAKL F+ + +G R++V
Sbjct: 175 RIERAGMDG--STRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKV 232
Query: 191 VKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESR 250
V+G L +PFALT S D LYWTDWQ SI+ + G K KE++ + P DI+V + R
Sbjct: 233 VEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGG-KRKEILSALYSPMDIQVLSQER 291
Query: 251 QIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQ 310
Q C+++N GCSHLCLLSP P Y CACPTGV+L++N T C + +L++A+
Sbjct: 292 QPFFHTR--CEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRT-CKAGAEEVLLLAR 348
Query: 311 RSTISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQS 370
R+ + +ISLD+PDFT L + D++ + +D+DP Y+YW D + I +A LDGS
Sbjct: 349 RTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQ 408
Query: 371 VVVRSS-GVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHL 429
+V + PD IA+D ++R +YWTD D I V RL+G+ K+++ +L +PRAIALH
Sbjct: 409 TLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHP 468
Query: 430 TAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKI 489
G M+W+DW E PKIE ANLDG R +L++ L WPN +ALD KLYWGDA+T KI
Sbjct: 469 VMGLMYWTDWGEN-PKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKI 527
Query: 490 EVCNMDGTERKELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMA 549
EV N+DGT+R+ L + + HIFG Q+R+++R++K R +++Q+
Sbjct: 528 EVINVDGTKRRTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHK-VKASRDVIIDQLP 586
Query: 550 NMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAF 609
++MG+KA + +G NPCAD NGGCSHLCF P CGCP+GLEL +D KTC+ PEAF
Sbjct: 587 DLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTCIVPEAF 646
Query: 610 LVYSRKNIIGRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNG 669
LV++ + I R+S++ ND IP+ +KE SAL VS + +YW+D KTI+R +NG
Sbjct: 647 LVFTSRAAIHRISLETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNG 706
Query: 670 SAVEKIVEW-LGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSI 728
S+VE +VE+ L EG+A+DW G+N+YW DT T RIEV+RLDG R+ ++W+ L P+S+
Sbjct: 707 SSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSL 766
Query: 729 VLDPKKGYMYWSELGSK-SIKRAAMDGSSVSVFMEQVGRVHALAIDYERRAIYWAALDPP 787
LDP KGY+YW+E G K I RA MDG++ +++VGR + L IDY + +YW LD
Sbjct: 767 ALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTN 826
Query: 788 VVEFAFLNGTGRQTLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDL 847
++E + + G R +AD++P P+ L ++D +YW DWN I++A KT G NR I+ L
Sbjct: 827 MIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHL 886
Query: 848 DYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS 907
D++ D+ ++H ++ G N C +NG C LCL PG +RC C +HY L+ + CS
Sbjct: 887 DFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPG----GHRCGCASHYTLDPSSRNCS 942
Query: 908 EPEEFLLFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIR 967
P FLLF+QK+A+ R++ + D +PL GL+NV+AI+YDP++K +YW+ D +I+
Sbjct: 943 PPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWV-DGRQNIK 1001
Query: 968 RVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGV 1027
R +P+ + +D+ RT++WTC ++IN + + + GV
Sbjct: 1002 RAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRL-SGEAMGV 1060
Query: 1028 IVRGDRMLPRHLAFHQTKRYLIWNDV-GRGA-IMRANVDGTGRVELARAD--NATALALD 1083
++RGDR PR + + + YL + ++ R A I RA +DGT R L AL +D
Sbjct: 1061 VLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVD 1120
Query: 1084 QSAGTVYW 1091
+ G ++W
Sbjct: 1121 NTLGKLFW 1128
Score = 495 bits (1222), Expect = e-139
Identities = 287/922 (31%), Positives = 475/922 (51%), Gaps = 36/922 (3%)
Query: 2 VNTSRLTRITTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSE 61
++T T I D+ A+D+ + + W+D + I+ + + G + +V+
Sbjct: 357 LDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGS--GAQ-TLVNT 413
Query: 62 GLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLM 121
+ P GIA+DW LYWTD T++IEV + RK+L ++D RAIA+ P GLM
Sbjct: 414 EINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLM 473
Query: 122 FWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVID 181
+WTDWGE PKIE A ++G R+V+V ++ WPNG+ +D +YW DAK ++VI+
Sbjct: 474 YWTDWGENPKIECANLDGQE--RRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVIN 531
Query: 182 FNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPA 241
+G KR+ +++ L + F T D +YWTDWQ SI + +I P
Sbjct: 532 VDGTKRRTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDV--IIDQLPDLM 589
Query: 242 DIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDS 301
+K + ++ ++ PC N GCSHLC +P C CP G++L + T
Sbjct: 590 GLKAVNVAK-VVGTN--PCADRNGGCSHLCFFTPHAT--RCGCPIGLELLSDMKTCIV-- 642
Query: 302 PQMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISK 361
P+ LV R+ I +ISL++ + +PL +K +DFD +IYW D KTIS+
Sbjct: 643 PEAFLVFTSRAAIHRISLETNN-NDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISR 701
Query: 362 ARLDGSD-QSVVVRSSGVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELY 420
A ++GS + VV P+ +A+D + + +YW D + I VARLDG + +V++ +L
Sbjct: 702 AFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLD 761
Query: 421 DPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLY 480
+PR++AL T G+++W++W K P+I RA +DG+ + L+ +K+ N + +D + +LY
Sbjct: 762 NPRSLALDPTKGYIYWTEWGGK-PRIVRAFMDGTNCMTLV-DKVGRANDLTIDYADQRLY 819
Query: 481 WGDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLD 540
W D T+ IE NM G ER + ++D+ H FG +++R +K +G +
Sbjct: 820 WTDLDTNMIESSNMLGQERVVI-ADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRN 878
Query: 541 RQPVVEQMANMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADK 600
R + + +M + F G N C +NG C LC P + CGC L
Sbjct: 879 RTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSS 938
Query: 601 KTCVEPEAFLVYSRKNIIGRLSIKNEYN-DAVIPIKDLKEVSALALYVSGSKLYWSDSKT 659
+ C P FL++S+K+ I R+ ++++ D ++P+ L+ V A+ +YW D +
Sbjct: 939 RNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGR- 997
Query: 660 KTINRCSVNGS---AVEKIVEWLG---LVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSS 713
+ I R +G+ + + + L+ID + ++WT T I V RL G +
Sbjct: 998 QNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEA 1057
Query: 714 RRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS--IKRAAMDGSSVSV-FMEQVGRVHAL 770
++ KP++IV++ ++GY+Y++ + ++ I+RAA+DG+ V F + R AL
Sbjct: 1058 MGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVAL 1117
Query: 771 AIDYERRAIYWAALDPPVVEFAFLNGTGRQTLAD-NIPMPYALALFNDSVYWGDWNTGQI 829
+D ++W D +E L+G R TL D NI P L + +YW D I
Sbjct: 1118 VVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMI 1177
Query: 830 QQARKTDGSNRKSIRKDLDYISDLKLYHRA--KSMGSNQCGVDNGGCSHLCLPTPGDVRT 887
++ KT G R I+ + +++ + + ++ C DNGGCSH+C+ GD
Sbjct: 1178 ERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICI-AKGDGTP 1236
Query: 888 DYRCACPAHYRLNKDNITCSEP 909
RC+CP H L ++ +TC EP
Sbjct: 1237 --RCSCPVHLVLLQNLLTCGEP 1256
Score = 70.5 bits (165), Expect = 3e-11
Identities = 49/183 (26%), Positives = 86/183 (46%), Gaps = 8/183 (4%)
Query: 913 LLFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPIS 972
LLFA + V R++ A G ++ I ++GL++ A+++ + +YW D +I++ +
Sbjct: 35 LLFANRRDV-RLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQ---T 90
Query: 973 YXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGD 1032
Y GL P + D +G+ +YWT ++ + I ++ N +S V+ D
Sbjct: 91 YLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANL-NGTSRKVLFWQD 149
Query: 1033 RMLPRHLAFHQTKRYLIWNDVGR-GAIMRANVDGTGRVELARADN--ATALALDQSAGTV 1089
PR +A Y+ W D G I RA +DG+ R + +D L +D +
Sbjct: 150 LDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKL 209
Query: 1090 YWA 1092
YWA
Sbjct: 210 YWA 212
Score = 66.5 bits (155), Expect = 5e-10
Identities = 33/97 (34%), Positives = 53/97 (54%)
Query: 411 EKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSI 470
E I+ + L D A+ + G ++W+D +E+ K N G+ ++ L P+ +
Sbjct: 54 ESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGL 113
Query: 471 ALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDI 507
A D V KLYW D+ T++IEV N++GT RK L D+
Sbjct: 114 ACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDL 150
Score = 42.7 bits (96), Expect = 0.008
Identities = 28/89 (31%), Positives = 33/89 (37%), Gaps = 10/89 (11%)
Query: 1096 QCDGQQDCEDGRDEAECGACGG-DVRCADGTXXXXXXXXXXXXXXXXXXXX---DA---- 1147
+CDG +C+D DE C C CA G DA
Sbjct: 1279 RCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEVDCDAICLP 1338
Query: 1148 --FRCDEGLCIAARFVCDGRPQCADGSDE 1174
FRC G C+ + CD P C DGSDE
Sbjct: 1339 NQFRCASGQCVLIKQQCDSFPDCIDGSDE 1367
>AB209683-1|BAD92920.1| 1477|Homo sapiens low density lipoprotein
receptor-related protein 6 variant protein.
Length = 1477
Score = 927 bits (2294), Expect = 0.0
Identities = 438/997 (43%), Positives = 627/997 (62%), Gaps = 20/997 (2%)
Query: 106 VDLARAIAVVPEDGLMFWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNS 165
+D RAIA+ P G M+WTDWGE+PKIERAGM+G ++R +I+ I+WPNG+T+DY
Sbjct: 1 LDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDG--SSRFIIINSEIYWPNGLTLDYEEQ 58
Query: 166 LIYWVDAKLQFVDVIDFNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAA 225
+YW DAKL F+ + +G R+ VVKG L +PFALT D LYWTDW SI +
Sbjct: 59 KLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACN-KY 117
Query: 226 NGPKIKELIKSHPVPADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACP 285
G ++E+ P DI + + RQ + PC +N GCSHLCL+SP P Y CACP
Sbjct: 118 TGEGLREIHSDIFSPMDIHAFSQQRQPNATN--PCGIDNGGCSHLCLMSPVKPFYQCACP 175
Query: 286 TGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRTLTVDFDPK 345
TGVKL EN T C D LL++A+R+ + +ISLD+PDFT L L+D++ + +D+DP
Sbjct: 176 TGVKLLENGKT-CKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPV 234
Query: 346 TEYIYWADGLAKTISKARLDGS-DQSVVVRSSGVPDSIAIDPLSRKIYWTDPVMDTINVA 404
YIYW D + I ++ +DGS Q VV PD IA+D ++R +YWTD D I V
Sbjct: 235 EGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVT 294
Query: 405 RLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKL 464
RL+G+ K++I +L +PRAI L G+M+W+DW E PKIERA LDGS RV+L++ L
Sbjct: 295 RLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEI-PKIERAALDGSDRVVLVNTSL 353
Query: 465 TWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXXXXXXXXXX 524
WPN +ALD K+YWGDA+T KIEV N DGT R+ L + I HIFG
Sbjct: 354 GWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTD 413
Query: 525 MQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRPD 584
Q+R+++R++K + +R+ +++Q+ ++MG+KA + +G NPCA++NGGCSHLC RP
Sbjct: 414 WQRRSIERVHKRSA-EREVIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQ 472
Query: 585 DYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGRLSIKNEYNDAVIPIKDLKEVSALA 644
C CP+G EL +D KTC+ PEAFL++SR+ I R+S++ N+ IP+ +KE SAL
Sbjct: 473 GLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASALD 532
Query: 645 LYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEW-LGLVEGLAIDWSGQNIYWTDTTTQR 703
V+ +++YW+D KTI+R +NGSA+E +VE+ L EG+A+DW G+N+YW DT T R
Sbjct: 533 FDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNR 592
Query: 704 IEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSK-SIKRAAMDGSSVSVFME 762
IEVS+LDG R+ ++W+ L P+++ LDP +G+MYW+E G K I RAAMDGS + +
Sbjct: 593 IEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVP 652
Query: 763 QVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPMPYALALFNDSVYWG 822
VGR + L IDY +R +YW LD ++E + + G R+ +AD++P P+ L + D +YW
Sbjct: 653 NVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWT 712
Query: 823 DWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTP 882
DW+ I++A KT G NR I+ LDY+ D+ ++H ++ G N+C NG CSHLCL P
Sbjct: 713 DWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVP 772
Query: 883 GDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVANGECNDAYIPLTGLK 942
+ C CPAHY LN DN TCS P FLLF+QK+A+ R+++ + D +P+ L+
Sbjct: 773 VG---GFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLR 829
Query: 943 NVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLS-RPYHMVLDVLG 1001
NVRAI+YDP++KQLYW+D + IR+ L +PY + +D+
Sbjct: 830 NVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYS 889
Query: 1002 RTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGA--IM 1059
R +YWTC + IN T +D S GV+++G++ PR + + K Y+ + ++ + I
Sbjct: 890 RYIYWTCEATNVINVTRLDGR-SVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERSPKIE 948
Query: 1060 RANVDGTGRVEL--ARADNATALALDQSAGTVYWAVS 1094
RA +DGT R L + ALALD G ++WA S
Sbjct: 949 RAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADS 985
Score = 555 bits (1371), Expect = e-157
Identities = 324/924 (35%), Positives = 493/924 (53%), Gaps = 37/924 (4%)
Query: 2 VNTSRLTRITTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSE 61
++T T I +D+ A+D+ + I W+D + I+ + + G +F +V+
Sbjct: 208 LDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGS--GSQF-VVTA 264
Query: 62 GLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLM 121
+ P GIA+DW LYWTD T++IEV + RK+L +++ RAI + P G M
Sbjct: 265 QIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYM 324
Query: 122 FWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVID 181
+WTDWGEIPKIERA ++G + R V+V ++ WPNG+ +DY+ IYW DAK ++V++
Sbjct: 325 YWTDWGEIPKIERAALDG--SDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMN 382
Query: 182 FNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPA 241
+G R+ +V+ + + F T D +YWTDWQ SI + + + +I P
Sbjct: 383 TDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIER--VHKRSAEREVIIDQLPDLM 440
Query: 242 DIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDS 301
+K + R I S PC + N GCSHLCL P G CACP G +L + TC
Sbjct: 441 GLKATNVHRVIGS---NPCAEENGGCSHLCLYRPQ--GLRCACPIGFELISDMK-TCI-V 493
Query: 302 PQMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISK 361
P+ L+ ++R+ I +ISL++ + +PL +K +DFD IYW D KTIS+
Sbjct: 494 PEAFLLFSRRADIRRISLETNN-NNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISR 552
Query: 362 ARLDGSD-QSVVVRSSGVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELY 420
A ++GS + VV P+ +A+D L + +YW D + I V++LDG + +V++ +L
Sbjct: 553 AFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLD 612
Query: 421 DPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLY 480
PRA+AL G+M+W++W KPKI+RA +DGS R L+ + N + +D +LY
Sbjct: 613 SPRALALDPAEGFMYWTEWG-GKPKIDRAAMDGSERTTLV-PNVGRANGLTIDYAKRRLY 670
Query: 481 WGDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLD 540
W D T+ IE NM G R E+ ++D+ H FG +R+++R NK +G +
Sbjct: 671 WTDLDTNLIESSNMLGLNR-EVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQN 729
Query: 541 RQPVVEQMANMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRP-DDYICGCPLGLELTAD 599
R + + +M + F GWN CA NG CSHLC P ++CGCP L AD
Sbjct: 730 RTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNAD 789
Query: 600 KKTCVEPEAFLVYSRKNIIGRLSIKNEYN-DAVIPIKDLKEVSALALYVSGSKLYWSDSK 658
+TC P FL++S+K+ I R+ I + + D ++PI L+ V A+ +LYW DS+
Sbjct: 790 NRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSR 849
Query: 659 TKTINRCSVNGS----AVEKIVEWLGL---VEGLAIDWSGQNIYWTDTTTQRIEVSRLDG 711
I + +GS V V L L+ID + IYWT T I V+RLDG
Sbjct: 850 QNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDG 909
Query: 712 SSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS--IKRAAMDGSSVSV-FMEQVGRVH 768
S ++ +P++IV++P+KGYMY++ L +S I+RAA+DG+ V F + +
Sbjct: 910 RSVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPI 969
Query: 769 ALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLAD-NIPMPYALALFNDSVYWGDWNTG 827
ALA+D ++WA D +E + L+G R L D NI P L +F + +YW D
Sbjct: 970 ALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQ 1029
Query: 828 QIQQARKTDGSNRKSIRKDLDYISDLKLYHRAKSMGSNQ--CGVDNGGCSHLCLPTPGDV 885
I++ T R ++ + +SD+ Q C DNGGCSH+CL GD
Sbjct: 1030 MIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICL-VKGDG 1088
Query: 886 RTDYRCACPAHYRLNKDNITCSEP 909
T RC+CP H L +D ++C EP
Sbjct: 1089 TT--RCSCPMHLVLLQDELSCGEP 1110
Score = 45.2 bits (102), Expect = 0.001
Identities = 28/107 (26%), Positives = 55/107 (51%), Gaps = 6/107 (5%)
Query: 66 PTGIAIDWYTDKLYWTD-GETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWT 124
P IA+D + +YWTD GE KIE + R ++ SE+ + + E+ ++W
Sbjct: 4 PRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWA 63
Query: 125 DWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVD 171
D ++ I ++ ++G R+ +V+ ++ P +T+ ++YW D
Sbjct: 64 D-AKLNFIHKSNLDG--TNRQAVVKGSLPHPFALTL--FEDILYWTD 105
Score = 44.0 bits (99), Expect = 0.003
Identities = 28/92 (30%), Positives = 33/92 (35%), Gaps = 10/92 (10%)
Query: 1093 VSRQCDGQQDCEDGRDEAECGACG-GDVRCADGTXXXXXXXXXXXXXXXXXXXX------ 1145
V+ +CDG +CED DE C C +CA G
Sbjct: 1130 VAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVL 1189
Query: 1146 ---DAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
D FRC G CI CD C+D SDE
Sbjct: 1190 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDE 1221
Score = 42.7 bits (96), Expect = 0.008
Identities = 19/72 (26%), Positives = 37/72 (51%), Gaps = 2/72 (2%)
Query: 55 KFKIVSEGLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAV 114
+F I++ + P G+ +D+ KLYW D + N I ++ R+ + + L A+
Sbjct: 37 RFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVV--KGSLPHPFAL 94
Query: 115 VPEDGLMFWTDW 126
+ +++WTDW
Sbjct: 95 TLFEDILYWTDW 106
>AB084910-1|BAD83615.1| 1905|Homo sapiens low density lipoprotein
receptor-related protein 10 protein.
Length = 1905
Score = 788 bits (1948), Expect = 0.0
Identities = 419/1095 (38%), Positives = 611/1095 (55%), Gaps = 38/1095 (3%)
Query: 11 TTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIA 70
T + +LE A+DFH+R+ L+ WSD + I N N + E +VS GL +P G+A
Sbjct: 461 TLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEE---VVSTGLESPGGLA 517
Query: 71 IDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIP 130
+DW DKLYWTD T++IEV ++ +RKVL W ++ RAIA+ P +G ++WTDWG P
Sbjct: 518 VDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTP 577
Query: 131 KIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRV 190
+IE + M+G + R++I ++FWPNG+T+DY +YWVDAK ++ + +G RK V
Sbjct: 578 RIEASSMDG--SGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAV 635
Query: 191 VKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSH-PVPADIKVYDES 249
+ GL +PFA+T D LYWTDW SI + + K +E+I++ P DI
Sbjct: 636 ISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTG--KNQEIIRNKLHFPMDIHTLHPQ 693
Query: 250 RQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVA 309
RQ A C NN GC+HLCL P Y CACPTG R+ SS C S L+ A
Sbjct: 694 RQ--PAGKNRCGDNNGGCTHLCL--PSGQNYTCACPTG--FRKISSHACAQSLDKFLLFA 747
Query: 310 QRSTISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQ 369
+R I +IS D+ D + +PL D++ + +D+D + +++YW D TIS+A+ DG+ Q
Sbjct: 748 RRMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQ 807
Query: 370 SVVVRSS-GVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALH 428
VVV +S P +AID ++ K+YWTD D I VA DGS V+I L PR I +
Sbjct: 808 EVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVE 867
Query: 429 LTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHK 488
G+M+W+DW PKIERA +D SGR ++IS LTWPN +A+D + +LYW DA
Sbjct: 868 PMGGYMYWTDWGAS-PKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKT 926
Query: 489 IEVCNMDGTERKELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQM 548
IE +DG++RK L + + H FG Q +++ ++ TGLDR+ + E +
Sbjct: 927 IEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENL 986
Query: 549 ANMMGVKAFRLGAPLGWNPCADDNGGCSHLCFN--RPDDYICGCPLGLELTADKKTCVE- 605
N+M + F P PCA +NGGCSHLC P + C CP G+ L +D KTC
Sbjct: 987 ENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSPG 1046
Query: 606 PEAFLVYSRKNIIGRLSIKNEY-NDAVIPIK-DLKEVSALALYVSGSKLYWSDSKTKTIN 663
+FL+++R+ I +S+ Y D V+PI +K A+ + K+YWSDS I+
Sbjct: 1047 MNSFLIFARRIDIRMVSLDIPYFADVVVPINITMKNTIAVGVDPQEGKVYWSDSTLHRIS 1106
Query: 664 RCSVNGSAVEKIV-EWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGL 722
R +++GS E I+ L +GLA+D G+ +YWTDT T RIEV LDGS R+ ++WQ L
Sbjct: 1107 RANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNL 1166
Query: 723 KKPKSIVLDPKKGYMYWSELGSKS-IKRAAMDGSSVSVFM-EQVGRVHALAIDYERRAIY 780
P++IVL + G+MYW++ G + ++R+ MDGS +V + +G + L +D +
Sbjct: 1167 DSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLL 1226
Query: 781 WAALDPPVVEFAFLNGTGRQTLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNR 840
WA +E A LNG R TL + PY L L + +YW DW T I +A K GSN
Sbjct: 1227 WADAHTERIEAADLNGANRHTLVSPVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNV 1286
Query: 841 KSIRKDLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLN 900
+R +L + D++ RA+ +G N+CG NGGCSHLCLP P + + CACP +L
Sbjct: 1287 ILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGCSHLCLPRP----SGFSCACPTGIQLK 1342
Query: 901 KDNITCS-EPEEFLLFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWM 959
D TC PE +LLF+ + ++ RI + + D ++P+ L NV +++YD V+ ++Y+
Sbjct: 1343 GDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGKVYYT 1402
Query: 960 DDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSI 1019
D IRR ++ GL + +D + R +YWT R++I A+ +
Sbjct: 1403 DVFLDVIRRADLN-----GSNMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRL 1457
Query: 1020 DNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGA-IMRANVDGTGRVELARADNA- 1077
D S V++ PR +A K YL W D G A I RAN+DG+ R L D
Sbjct: 1458 D-GSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGW 1516
Query: 1078 -TALALDQSAGTVYW 1091
L LD +YW
Sbjct: 1517 PNGLTLDYDTRRIYW 1531
Score = 673 bits (1664), Expect = 0.0
Identities = 334/886 (37%), Positives = 502/886 (56%), Gaps = 23/886 (2%)
Query: 16 DLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAIDWYT 75
D+ A+D+ R + + W+D + I ++ T G++ +V L +P G+AIDW T
Sbjct: 771 DVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGT--GQEV-VVDTSLESPAGLAIDWVT 827
Query: 76 DKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERA 135
+KLYWTD T++IEV + R VL W +D R I V P G M+WTDWG PKIERA
Sbjct: 828 NKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERA 887
Query: 136 GMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVKGGL 195
GM D + R+VI+ N+ WPNG+ +DY + +YW DA ++ ++ +G KRK ++ L
Sbjct: 888 GM--DASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQL 945
Query: 196 VYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESRQIISA 255
+PF LT +++YWTDWQ SI + D G + L ++ DI V+ R +S
Sbjct: 946 PHPFGLTLYGERIYWTDWQTKSIQSAD-RLTGLDRETLQENLENLMDIHVFHRRRPPVST 1004
Query: 256 EDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTIS 315
PC N GCSHLCL SP+P G++C CPTG+ L + T C L+ A+R I
Sbjct: 1005 ---PCAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKT-CSPGMNSFLIFARRIDIR 1060
Query: 316 KISLDSPDFTPYTLPLK-DLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSD-QSVVV 373
+SLD P F +P+ +K T+ V DP+ +YW+D IS+A LDGS + ++
Sbjct: 1061 MVSLDIPYFADVVVPINITMKNTIAVGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIIT 1120
Query: 374 RSSGVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGW 433
D +A+D + RK+YWTD + I V LDGS KV++ L PRAI L+ G+
Sbjct: 1121 TGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGF 1180
Query: 434 MFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCN 493
M+W+DW E K+ER+ +DGS R +LI+ L WPN + +D +++L W DA T +IE +
Sbjct: 1181 MYWTDWGENA-KLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAAD 1239
Query: 494 MDGTERKELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMG 553
++G R L S + H +G Q R++ R +K TG + V + +M
Sbjct: 1240 LNGANRHTLVS-PVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMD 1298
Query: 554 VKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC-VEPEAFLVY 612
++A PLG+N C NGGCSHLC RP + C CP G++L D KTC PE +L++
Sbjct: 1299 MQAVDRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLF 1358
Query: 613 SRKNIIGRLSIK-NEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSA 671
S + I R+S+ +++ D +P+ +L V +L K+Y++D I R +NGS
Sbjct: 1359 SSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSN 1418
Query: 672 VEKIV-EWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVL 730
+E ++ L +GLA+DW +N+YWTDT IE SRLDGS R+ +I L +P++I +
Sbjct: 1419 METVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAV 1478
Query: 731 DPKKGYMYWSELGS-KSIKRAAMDGSSVSVFME-QVGRVHALAIDYERRAIYWAALDPPV 788
P+KGY++W++ G I+RA +DGS V + +G + L +DY+ R IYW
Sbjct: 1479 FPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDR 1538
Query: 789 VEFAFLNGTGRQTLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLD 848
+E A LNG RQ L ++ P+AL + +YW DW T IQ+ K G N++++ +++
Sbjct: 1539 IESADLNGKLRQVLVGHVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVE 1598
Query: 849 YISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACP 894
+ D+ + + G+N CGV+NGGC+HLC +D+ CACP
Sbjct: 1599 GLMDIIVVSPQRQTGTNACGVNNGGCTHLCFAR----ASDFVCACP 1640
Score = 502 bits (1239), Expect = e-141
Identities = 277/839 (33%), Positives = 438/839 (52%), Gaps = 28/839 (3%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDSPDFTP 326
CS C S + C C TG +LR + + P+ +L+ A R I ++ P +
Sbjct: 405 CSQGCTNSEG--AFQCWCETGYELRPDRRSCKALGPEPVLLFANRIDIRQVL---PHRSE 459
Query: 327 YTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGV--PDSIAI 384
YTL L +L+ + +DF + E ++W+D I +A L+GS+ VV S+G+ P +A+
Sbjct: 460 YTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVV-STGLESPGGLAV 518
Query: 385 DPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKP 444
D + K+YWTD I VA LDG++ KV++ L PRAIALH G ++W+DW P
Sbjct: 519 DWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWG-NTP 577
Query: 445 KIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHS 504
+IE +++DGSGR ++ L WPN + +D ++YW DA+ H IE N+DG+ RK + S
Sbjct: 578 RIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVIS 637
Query: 505 NDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFR-LGAPL 563
+ H F ++++ NK TG +++ + ++ M + P
Sbjct: 638 QGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPA 697
Query: 564 GWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGRLSI 623
G N C D+NGGC+HLC +Y C CP G + + FL+++R+ I R+S
Sbjct: 698 GKNRCGDNNGGCTHLCLPSGQNYTCACPTGFRKISSHACAQSLDKFLLFARRMDIRRISF 757
Query: 624 KNE-YNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEW-LGL 681
E +D VIP+ D++ AL +YW+D T TI+R +G+ E +V+ L
Sbjct: 758 DTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLES 817
Query: 682 VEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSE 741
GLAIDW +YWTD T RIEV+ DGS R +IW+ L +P+ IV++P GYMYW++
Sbjct: 818 PAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTD 877
Query: 742 LG-SKSIKRAAMDGSSVSVFM-EQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGR 799
G S I+RA MD S V + + + LAIDY + +YWA +EFA L+G+ R
Sbjct: 878 WGASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKR 937
Query: 800 QTL-ADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHR 858
+ L +P P+ L L+ + +YW DW T IQ A + G +R++++++L+ + D+ ++HR
Sbjct: 938 KVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHR 997
Query: 859 AKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSE-PEEFLLFAQ 917
+ S C ++NGGCSHLCL +P + + C CP L D TCS FL+FA+
Sbjct: 998 RRPPVSTPCAMENGGCSHLCLRSPNP--SGFSCTCPTGINLLSDGKTCSPGMNSFLIFAR 1055
Query: 918 KNAVGRIMVANGECNDAYIPLT-GLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXX 976
+ + + + D +P+ +KN A+ DP E ++YW D H I R +
Sbjct: 1056 RIDIRMVSLDIPYFADVVVPINITMKNTIAVGVDPQEGKVYWSDSTLHRISRANLD---- 1111
Query: 977 XXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLP 1036
GL + +D +GR +YWT + I ++D S V+V + P
Sbjct: 1112 -GSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLD-GSMRKVLVWQNLDSP 1169
Query: 1037 RHLAFHQTKRYLIWNDVGRGA-IMRANVDGTGRVELARADNA--TALALDQSAGTVYWA 1092
R + + ++ W D G A + R+ +DG+ R L + L +D+++ + WA
Sbjct: 1170 RAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWA 1228
Score = 302 bits (741), Expect = 5e-81
Identities = 176/539 (32%), Positives = 285/539 (52%), Gaps = 27/539 (5%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC--VEPEAFLVY-SRKNIIGRLS 622
N CA++ G CS C N + C C G EL D+++C + PE L++ +R +I L
Sbjct: 397 NECAEE-GYCSQGCTNSEGAFQCWCETGYELRPDRRSCKALGPEPVLLFANRIDIRQVLP 455
Query: 623 IKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVE-WLGL 681
++EY + + +L+ AL + ++WSD I R ++NGS VE++V L
Sbjct: 456 HRSEY---TLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLES 512
Query: 682 VEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSE 741
GLA+DW +YWTD+ T RIEV+ LDG+ R+ ++WQ L+KP++I L P +G +YW++
Sbjct: 513 PGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTD 572
Query: 742 LG-SKSIKRAAMDGSSVSVFME-QVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGR 799
G + I+ ++MDGS + + + + L IDY R +YW V+E A L+G+ R
Sbjct: 573 WGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHR 632
Query: 800 Q-TLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYH- 857
+ ++ +P P+A+ +F DS+YW DW+T I A K G N++ IR L + D+ H
Sbjct: 633 KAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHP 692
Query: 858 RAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQ 917
+ + G N+CG +NGGC+HLCLP+ +Y CACP +R + ++FLLFA+
Sbjct: 693 QRQPAGKNRCGDNNGGCTHLCLPS----GQNYTCACPTGFRKISSHACAQSLDKFLLFAR 748
Query: 918 KNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXX 977
+ + RI + +D IPL +++ A+++D + +YW D + +I R
Sbjct: 749 RMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISR-----AKWD 803
Query: 978 XXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPR 1037
L P + +D + +YWT A D I + D + T V++ + PR
Sbjct: 804 GTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRT-VLIWENLDRPR 862
Query: 1038 HLAFHQTKRYLIWNDVGRG-AIMRANVDGTGRVELARADNAT---ALALDQSAGTVYWA 1092
+ Y+ W D G I RA +D +GR ++ + N T LA+D + +YWA
Sbjct: 863 DIVVEPMGGYMYWTDWGASPKIERAGMDASGR-QVIISSNLTWPNGLAIDYGSQRLYWA 920
Score = 52.8 bits (121), Expect = 7e-06
Identities = 57/233 (24%), Positives = 83/233 (35%), Gaps = 20/233 (8%)
Query: 863 GSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL--FAQKNA 920
G C V+NGGC+ C G V +C C YRL +D TC + E + +
Sbjct: 354 GEENCNVNNGGCAQKCQMVRGAV----QCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGC 409
Query: 921 VGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXX 980
C Y ++ +A+ +PV +D IR+V
Sbjct: 410 TNSEGAFQCWCETGYELRPDRRSCKALGPEPVLLFANRID-----IRQVLPHRSEYTLLL 464
Query: 981 XXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLA 1040
L + L ++W+ D I ++ N S+ +V P LA
Sbjct: 465 NNLENAIALDFHHRREL------VFWSDVTLDRILRANL-NGSNVEEVVSTGLESPGGLA 517
Query: 1041 FHQTKRYLIWNDVGRGAIMRANVDGTGRVEL--ARADNATALALDQSAGTVYW 1091
L W D G I AN+DG R L + A+AL GT+YW
Sbjct: 518 VDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYW 570
Score = 46.4 bits (105), Expect = 6e-04
Identities = 31/96 (32%), Positives = 34/96 (35%), Gaps = 18/96 (18%)
Query: 1097 CDGQQDCEDGRDEAEC------------------GACGGDVRCADGTXXXXXXXXXXXXX 1138
CDG DC+DG DE C G C D+ DG
Sbjct: 167 CDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCS 226
Query: 1139 XXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
F CD GLCI A + CDG C D SDE
Sbjct: 227 SHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDE 262
Score = 46.0 bits (104), Expect = 8e-04
Identities = 25/85 (29%), Positives = 30/85 (35%), Gaps = 3/85 (3%)
Query: 1091 WAVSRQCDGQQDCEDGRDEAECGAC-GGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFR 1149
W+ C Q C G + G C RC DG + FR
Sbjct: 219 WSDESDCSSHQPCRSGEFMCDSGLCINAGWRC-DGDADCDDQSDERNCTTSMCTA-EQFR 276
Query: 1150 CDEGLCIAARFVCDGRPQCADGSDE 1174
C G C+ + CDG CAD SDE
Sbjct: 277 CHSGRCVRLSWRCDGEDDCADNSDE 301
Score = 42.7 bits (96), Expect = 0.008
Identities = 30/96 (31%), Positives = 38/96 (39%), Gaps = 23/96 (23%)
Query: 1093 VSRQCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDE 1152
+S +CDG+ DC D DE C G +CA D F C
Sbjct: 285 LSWRCDGEDDCADNSDEENCENTGSP-QCA----------------------LDQFLCWN 321
Query: 1153 GLCIAARFVCDGRPQCADGSDEAPAACAYGHTDQVN 1188
G CI R +C+G C D SDE+P T + N
Sbjct: 322 GRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEEN 357
Score = 42.3 bits (95), Expect = 0.010
Identities = 27/82 (32%), Positives = 34/82 (41%), Gaps = 5/82 (6%)
Query: 1095 RQC-DGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEG 1153
R+C D + C DG AE C GD C DG+ + F+C G
Sbjct: 146 RKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNL----EEFQCAYG 201
Query: 1154 LCIAARFVCDGRPQCADGSDEA 1175
CI + CDG C D SDE+
Sbjct: 202 RCILDIYHCDGDDDCGDWSDES 223
Score = 38.3 bits (85), Expect = 0.16
Identities = 28/92 (30%), Positives = 31/92 (33%), Gaps = 13/92 (14%)
Query: 1096 QCDGQQDCEDGRDEAEC--GACGG-DVRCADGTXXXXXXXXXXXXXXXXXXXX------- 1145
QCDG DC D DE C C D C +G
Sbjct: 50 QCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRE 109
Query: 1146 ---DAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
D F C G CI + + CDG C D SDE
Sbjct: 110 CEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDE 141
>AB011540-1|BAA32468.1| 1576|Homo sapiens MEGF7 protein.
Length = 1576
Score = 788 bits (1948), Expect = 0.0
Identities = 419/1095 (38%), Positives = 611/1095 (55%), Gaps = 38/1095 (3%)
Query: 11 TTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIA 70
T + +LE A+DFH+R+ L+ WSD + I N N + E +VS GL +P G+A
Sbjct: 132 TLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEE---VVSTGLESPGGLA 188
Query: 71 IDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIP 130
+DW DKLYWTD T++IEV ++ +RKVL W ++ RAIA+ P +G ++WTDWG P
Sbjct: 189 VDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTP 248
Query: 131 KIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRV 190
+IE + M+G + R++I ++FWPNG+T+DY +YWVDAK ++ + +G RK V
Sbjct: 249 RIEASSMDG--SGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAV 306
Query: 191 VKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSH-PVPADIKVYDES 249
+ GL +PFA+T D LYWTDW SI + + K +E+I++ P DI
Sbjct: 307 ISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTG--KNQEIIRNKLHFPMDIHTLHPQ 364
Query: 250 RQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVA 309
RQ A C NN GC+HLCL P Y CACPTG R+ SS C S L+ A
Sbjct: 365 RQ--PAGKNRCGDNNGGCTHLCL--PSGQNYTCACPTG--FRKISSHACAQSLDKFLLFA 418
Query: 310 QRSTISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQ 369
+R I +IS D+ D + +PL D++ + +D+D + +++YW D TIS+A+ DG+ Q
Sbjct: 419 RRMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQ 478
Query: 370 SVVVRSS-GVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALH 428
VVV +S P +AID ++ K+YWTD D I VA DGS V+I L PR I +
Sbjct: 479 EVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVE 538
Query: 429 LTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHK 488
G+M+W+DW PKIERA +D SGR ++IS LTWPN +A+D + +LYW DA
Sbjct: 539 PMGGYMYWTDWGAS-PKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKT 597
Query: 489 IEVCNMDGTERKELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQM 548
IE +DG++RK L + + H FG Q +++ ++ TGLDR+ + E +
Sbjct: 598 IEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENL 657
Query: 549 ANMMGVKAFRLGAPLGWNPCADDNGGCSHLCFN--RPDDYICGCPLGLELTADKKTCVE- 605
N+M + F P PCA +NGGCSHLC P + C CP G+ L +D KTC
Sbjct: 658 ENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSPG 717
Query: 606 PEAFLVYSRKNIIGRLSIKNEY-NDAVIPIK-DLKEVSALALYVSGSKLYWSDSKTKTIN 663
+FL+++R+ I +S+ Y D V+PI +K A+ + K+YWSDS I+
Sbjct: 718 MNSFLIFARRIDIRMVSLDIPYFADVVVPINITMKNTIAVGVDPQEGKVYWSDSTLHRIS 777
Query: 664 RCSVNGSAVEKIV-EWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGL 722
R +++GS E I+ L +GLA+D G+ +YWTDT T RIEV LDGS R+ ++WQ L
Sbjct: 778 RANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNL 837
Query: 723 KKPKSIVLDPKKGYMYWSELGSKS-IKRAAMDGSSVSVFM-EQVGRVHALAIDYERRAIY 780
P++IVL + G+MYW++ G + ++R+ MDGS +V + +G + L +D +
Sbjct: 838 DSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLL 897
Query: 781 WAALDPPVVEFAFLNGTGRQTLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNR 840
WA +E A LNG R TL + PY L L + +YW DW T I +A K GSN
Sbjct: 898 WADAHTERIEAADLNGANRHTLVSPVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNV 957
Query: 841 KSIRKDLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLN 900
+R +L + D++ RA+ +G N+CG NGGCSHLCLP P + + CACP +L
Sbjct: 958 ILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGCSHLCLPRP----SGFSCACPTGIQLK 1013
Query: 901 KDNITCS-EPEEFLLFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWM 959
D TC PE +LLF+ + ++ RI + + D ++P+ L NV +++YD V+ ++Y+
Sbjct: 1014 GDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGKVYYT 1073
Query: 960 DDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSI 1019
D IRR ++ GL + +D + R +YWT R++I A+ +
Sbjct: 1074 DVFLDVIRRADLN-----GSNMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRL 1128
Query: 1020 DNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGA-IMRANVDGTGRVELARADNA- 1077
D S V++ PR +A K YL W D G A I RAN+DG+ R L D
Sbjct: 1129 D-GSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGW 1187
Query: 1078 -TALALDQSAGTVYW 1091
L LD +YW
Sbjct: 1188 PNGLTLDYDTRRIYW 1202
Score = 673 bits (1664), Expect = 0.0
Identities = 334/886 (37%), Positives = 502/886 (56%), Gaps = 23/886 (2%)
Query: 16 DLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAIDWYT 75
D+ A+D+ R + + W+D + I ++ T G++ +V L +P G+AIDW T
Sbjct: 442 DVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGT--GQEV-VVDTSLESPAGLAIDWVT 498
Query: 76 DKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERA 135
+KLYWTD T++IEV + R VL W +D R I V P G M+WTDWG PKIERA
Sbjct: 499 NKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERA 558
Query: 136 GMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVKGGL 195
GM D + R+VI+ N+ WPNG+ +DY + +YW DA ++ ++ +G KRK ++ L
Sbjct: 559 GM--DASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQL 616
Query: 196 VYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESRQIISA 255
+PF LT +++YWTDWQ SI + D G + L ++ DI V+ R +S
Sbjct: 617 PHPFGLTLYGERIYWTDWQTKSIQSAD-RLTGLDRETLQENLENLMDIHVFHRRRPPVST 675
Query: 256 EDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTIS 315
PC N GCSHLCL SP+P G++C CPTG+ L + T C L+ A+R I
Sbjct: 676 ---PCAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKT-CSPGMNSFLIFARRIDIR 731
Query: 316 KISLDSPDFTPYTLPLK-DLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSD-QSVVV 373
+SLD P F +P+ +K T+ V DP+ +YW+D IS+A LDGS + ++
Sbjct: 732 MVSLDIPYFADVVVPINITMKNTIAVGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIIT 791
Query: 374 RSSGVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGW 433
D +A+D + RK+YWTD + I V LDGS KV++ L PRAI L+ G+
Sbjct: 792 TGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGF 851
Query: 434 MFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCN 493
M+W+DW E K+ER+ +DGS R +LI+ L WPN + +D +++L W DA T +IE +
Sbjct: 852 MYWTDWGENA-KLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAAD 910
Query: 494 MDGTERKELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMG 553
++G R L S + H +G Q R++ R +K TG + V + +M
Sbjct: 911 LNGANRHTLVS-PVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMD 969
Query: 554 VKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC-VEPEAFLVY 612
++A PLG+N C NGGCSHLC RP + C CP G++L D KTC PE +L++
Sbjct: 970 MQAVDRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLF 1029
Query: 613 SRKNIIGRLSIK-NEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSA 671
S + I R+S+ +++ D +P+ +L V +L K+Y++D I R +NGS
Sbjct: 1030 SSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSN 1089
Query: 672 VEKIV-EWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVL 730
+E ++ L +GLA+DW +N+YWTDT IE SRLDGS R+ +I L +P++I +
Sbjct: 1090 METVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAV 1149
Query: 731 DPKKGYMYWSELGS-KSIKRAAMDGSSVSVFME-QVGRVHALAIDYERRAIYWAALDPPV 788
P+KGY++W++ G I+RA +DGS V + +G + L +DY+ R IYW
Sbjct: 1150 FPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDR 1209
Query: 789 VEFAFLNGTGRQTLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLD 848
+E A LNG RQ L ++ P+AL + +YW DW T IQ+ K G N++++ +++
Sbjct: 1210 IESADLNGKLRQVLVGHVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVE 1269
Query: 849 YISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACP 894
+ D+ + + G+N CGV+NGGC+HLC +D+ CACP
Sbjct: 1270 GLMDIIVVSPQRQTGTNACGVNNGGCTHLCFAR----ASDFVCACP 1311
Score = 502 bits (1239), Expect = e-141
Identities = 277/839 (33%), Positives = 438/839 (52%), Gaps = 28/839 (3%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDSPDFTP 326
CS C S + C C TG +LR + + P+ +L+ A R I ++ P +
Sbjct: 76 CSQGCTNSEG--AFQCWCETGYELRPDRRSCKALGPEPVLLFANRIDIRQVL---PHRSE 130
Query: 327 YTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGV--PDSIAI 384
YTL L +L+ + +DF + E ++W+D I +A L+GS+ VV S+G+ P +A+
Sbjct: 131 YTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVV-STGLESPGGLAV 189
Query: 385 DPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKP 444
D + K+YWTD I VA LDG++ KV++ L PRAIALH G ++W+DW P
Sbjct: 190 DWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWG-NTP 248
Query: 445 KIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHS 504
+IE +++DGSGR ++ L WPN + +D ++YW DA+ H IE N+DG+ RK + S
Sbjct: 249 RIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVIS 308
Query: 505 NDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFR-LGAPL 563
+ H F ++++ NK TG +++ + ++ M + P
Sbjct: 309 QGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPA 368
Query: 564 GWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGRLSI 623
G N C D+NGGC+HLC +Y C CP G + + FL+++R+ I R+S
Sbjct: 369 GKNRCGDNNGGCTHLCLPSGQNYTCACPTGFRKISSHACAQSLDKFLLFARRMDIRRISF 428
Query: 624 KNE-YNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEW-LGL 681
E +D VIP+ D++ AL +YW+D T TI+R +G+ E +V+ L
Sbjct: 429 DTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLES 488
Query: 682 VEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSE 741
GLAIDW +YWTD T RIEV+ DGS R +IW+ L +P+ IV++P GYMYW++
Sbjct: 489 PAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTD 548
Query: 742 LG-SKSIKRAAMDGSSVSVFM-EQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGR 799
G S I+RA MD S V + + + LAIDY + +YWA +EFA L+G+ R
Sbjct: 549 WGASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKR 608
Query: 800 QTL-ADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHR 858
+ L +P P+ L L+ + +YW DW T IQ A + G +R++++++L+ + D+ ++HR
Sbjct: 609 KVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHR 668
Query: 859 AKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSE-PEEFLLFAQ 917
+ S C ++NGGCSHLCL +P + + C CP L D TCS FL+FA+
Sbjct: 669 RRPPVSTPCAMENGGCSHLCLRSPNP--SGFSCTCPTGINLLSDGKTCSPGMNSFLIFAR 726
Query: 918 KNAVGRIMVANGECNDAYIPLT-GLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXX 976
+ + + + D +P+ +KN A+ DP E ++YW D H I R +
Sbjct: 727 RIDIRMVSLDIPYFADVVVPINITMKNTIAVGVDPQEGKVYWSDSTLHRISRANLD---- 782
Query: 977 XXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLP 1036
GL + +D +GR +YWT + I ++D S V+V + P
Sbjct: 783 -GSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLD-GSMRKVLVWQNLDSP 840
Query: 1037 RHLAFHQTKRYLIWNDVGRGA-IMRANVDGTGRVELARADNA--TALALDQSAGTVYWA 1092
R + + ++ W D G A + R+ +DG+ R L + L +D+++ + WA
Sbjct: 841 RAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWA 899
Score = 302 bits (741), Expect = 5e-81
Identities = 176/539 (32%), Positives = 285/539 (52%), Gaps = 27/539 (5%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC--VEPEAFLVY-SRKNIIGRLS 622
N CA++ G CS C N + C C G EL D+++C + PE L++ +R +I L
Sbjct: 68 NECAEE-GYCSQGCTNSEGAFQCWCETGYELRPDRRSCKALGPEPVLLFANRIDIRQVLP 126
Query: 623 IKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVE-WLGL 681
++EY + + +L+ AL + ++WSD I R ++NGS VE++V L
Sbjct: 127 HRSEY---TLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLES 183
Query: 682 VEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSE 741
GLA+DW +YWTD+ T RIEV+ LDG+ R+ ++WQ L+KP++I L P +G +YW++
Sbjct: 184 PGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTD 243
Query: 742 LG-SKSIKRAAMDGSSVSVFME-QVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGR 799
G + I+ ++MDGS + + + + L IDY R +YW V+E A L+G+ R
Sbjct: 244 WGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHR 303
Query: 800 Q-TLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYH- 857
+ ++ +P P+A+ +F DS+YW DW+T I A K G N++ IR L + D+ H
Sbjct: 304 KAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHP 363
Query: 858 RAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQ 917
+ + G N+CG +NGGC+HLCLP+ +Y CACP +R + ++FLLFA+
Sbjct: 364 QRQPAGKNRCGDNNGGCTHLCLPS----GQNYTCACPTGFRKISSHACAQSLDKFLLFAR 419
Query: 918 KNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXX 977
+ + RI + +D IPL +++ A+++D + +YW D + +I R
Sbjct: 420 RMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISR-----AKWD 474
Query: 978 XXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPR 1037
L P + +D + +YWT A D I + D + T V++ + PR
Sbjct: 475 GTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRT-VLIWENLDRPR 533
Query: 1038 HLAFHQTKRYLIWNDVGRG-AIMRANVDGTGRVELARADNAT---ALALDQSAGTVYWA 1092
+ Y+ W D G I RA +D +GR ++ + N T LA+D + +YWA
Sbjct: 534 DIVVEPMGGYMYWTDWGASPKIERAGMDASGR-QVIISSNLTWPNGLAIDYGSQRLYWA 591
Score = 52.8 bits (121), Expect = 7e-06
Identities = 57/233 (24%), Positives = 83/233 (35%), Gaps = 20/233 (8%)
Query: 863 GSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL--FAQKNA 920
G C V+NGGC+ C G V +C C YRL +D TC + E + +
Sbjct: 25 GEENCNVNNGGCAQKCQMVRGAV----QCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGC 80
Query: 921 VGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXX 980
C Y ++ +A+ +PV +D IR+V
Sbjct: 81 TNSEGAFQCWCETGYELRPDRRSCKALGPEPVLLFANRID-----IRQVLPHRSEYTLLL 135
Query: 981 XXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLA 1040
L + L ++W+ D I ++ N S+ +V P LA
Sbjct: 136 NNLENAIALDFHHRREL------VFWSDVTLDRILRANL-NGSNVEEVVSTGLESPGGLA 188
Query: 1041 FHQTKRYLIWNDVGRGAIMRANVDGTGRVEL--ARADNATALALDQSAGTVYW 1091
L W D G I AN+DG R L + A+AL GT+YW
Sbjct: 189 VDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYW 241
>AB231861-1|BAE19679.1| 1950|Homo sapiens low-density lipoprotein
receptor-related protein 4 protein.
Length = 1950
Score = 779 bits (1926), Expect = 0.0
Identities = 418/1095 (38%), Positives = 611/1095 (55%), Gaps = 41/1095 (3%)
Query: 11 TTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIA 70
T + +LE A+DFH+R+ L+ WSD + I N N + E +VS GL +P G+A
Sbjct: 509 TLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEE---VVSTGLESPGGLA 565
Query: 71 IDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIP 130
+DW DKLYWTD T++IEV ++ +RKVL W ++ RAIA+ P +G ++WTDWG P
Sbjct: 566 VDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTP 625
Query: 131 KIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRV 190
+IE + M+G + R++I ++FWPNG+T+DY +YWVDAK ++ + +G RK V
Sbjct: 626 RIEASSMDG--SGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAV 683
Query: 191 VKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSH-PVPADIKVYDES 249
+ GL +PFA+T D LYWTDW SI + + K +E+I++ P DI
Sbjct: 684 ISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTG--KNQEIIRNKLHFPMDIHTLHPQ 741
Query: 250 RQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVA 309
RQ A C NN GC+HLCL P Y CACPTG R+ SS C S L+ A
Sbjct: 742 RQ--PAGKNRCGDNNGGCTHLCL--PSGQNYTCACPTG--FRKISSHACAQSLDKFLLFA 795
Query: 310 QRSTISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQ 369
+R I +IS D+ D + +PL D++ + +D+D + +++YW D TIS+A+ DG+ Q
Sbjct: 796 RRMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQ 855
Query: 370 SVVVRSS-GVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALH 428
VVV +S P +AID ++ K+YWTD D I VA DGS V+I L PR I +
Sbjct: 856 EVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVE 915
Query: 429 LTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHK 488
G+M+W+DW PKIERA +D SGR ++IS LTWPN +A+D + +LYW DA
Sbjct: 916 PMGGYMYWTDWGAS-PKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKT 974
Query: 489 IEVCNMDGTERKELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQM 548
IE +DG++RK L + + H FG Q +++ ++ TGLDR+ + E +
Sbjct: 975 IEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENL 1034
Query: 549 ANMMGVKAFRLGAPLGWNPCADDNGGCSHLCFN--RPDDYICGCPLGLELTADKKTCVE- 605
N+M + F P PCA +NGGCSHLC P + C CP G+ L +D KTC
Sbjct: 1035 ENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSPG 1094
Query: 606 PEAFLVYSRKNIIGRLSIKNEY-NDAVIPIK-DLKEVSALALYVSGSKLYWSDSKTKTIN 663
+FL+++R+ I +S+ Y D V+PI +K A+ + K+YWSDS I+
Sbjct: 1095 MNSFLIFARRIDIRMVSLDIPYFADVVVPINITMKNTIAVGVDPQEGKVYWSDSTLHRIS 1154
Query: 664 RCSVNGSAVEKIV-EWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGL 722
R +++GS E I+ L +GLA+D G+ +YWTDT T RIEV LDGS R+ ++WQ L
Sbjct: 1155 RANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNL 1214
Query: 723 KKPKSIVLDPKKGYMYWSELGSKS-IKRAAMDGSSVSVFM-EQVGRVHALAIDYERRAIY 780
P++IVL + G+MYW++ G + ++R+ MDGS +V + +G + L +D +
Sbjct: 1215 DSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLL 1274
Query: 781 WAALDPPVVEFAFLNGTGRQTLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNR 840
WA +E A LNG R TL + PY L L + +YW DW T I +A K GSN
Sbjct: 1275 WADAHTERIEAADLNGANRHTLVSPVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNV 1334
Query: 841 KSIRKDLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLN 900
+R +L + D++ RA+ +G N+CG NGGCSHLCLP P + + CACP +L
Sbjct: 1335 ILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGCSHLCLPRP----SGFSCACPTGIQLK 1390
Query: 901 KDNITCS-EPEEFLLFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWM 959
D TC PE +LLF+ + ++ RI + + D ++P+ L NV +++YD V+ ++Y+
Sbjct: 1391 GDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGKVYYT 1450
Query: 960 DDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSI 1019
D IRR ++ GL + +D + R +YWT R++I A+ +
Sbjct: 1451 DVFLDVIRRADLN-----GSNMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRL 1505
Query: 1020 DNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGA-IMRANVDGTGRVELARADNA- 1077
D + +I + L AF + K YL W D G A I RAN+DG+ R L D
Sbjct: 1506 DGSCRKVLI---NNSLDDIAAFPR-KGYLFWTDWGHIAKIERANLDGSERKVLINTDLGW 1561
Query: 1078 -TALALDQSAGTVYW 1091
L LD +YW
Sbjct: 1562 PNGLTLDYDTRRIYW 1576
Score = 662 bits (1636), Expect = 0.0
Identities = 333/886 (37%), Positives = 497/886 (56%), Gaps = 26/886 (2%)
Query: 16 DLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAIDWYT 75
D+ A+D+ R + + W+D + I ++ T G++ +V L +P G+AIDW T
Sbjct: 819 DVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGT--GQEV-VVDTSLESPAGLAIDWVT 875
Query: 76 DKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERA 135
+KLYWTD T++IEV + R VL W +D R I V P G M+WTDWG PKIERA
Sbjct: 876 NKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERA 935
Query: 136 GMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVKGGL 195
GM D + R+VI+ N+ WPNG+ +DY + +YW DA ++ ++ +G KRK ++ L
Sbjct: 936 GM--DASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQL 993
Query: 196 VYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESRQIISA 255
+PF LT +++YWTDWQ SI + D G + L ++ DI V+ R +S
Sbjct: 994 PHPFGLTLYGERIYWTDWQTKSIQSAD-RLTGLDRETLQENLENLMDIHVFHRRRPPVST 1052
Query: 256 EDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTIS 315
PC N GCSHLCL SP+P G++C CPTG+ L + T C L+ A+R I
Sbjct: 1053 ---PCAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKT-CSPGMNSFLIFARRIDIR 1108
Query: 316 KISLDSPDFTPYTLPLK-DLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSD-QSVVV 373
+SLD P F +P+ +K T+ V DP+ +YW+D IS+A LDGS + ++
Sbjct: 1109 MVSLDIPYFADVVVPINITMKNTIAVGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIIT 1168
Query: 374 RSSGVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGW 433
D +A+D + RK+YWTD + I V LDGS KV++ L PRAI L+ G+
Sbjct: 1169 TGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGF 1228
Query: 434 MFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCN 493
M+W+DW E K+ER+ +DGS R +LI+ L WPN + +D +++L W DA T +IE +
Sbjct: 1229 MYWTDWGENA-KLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAAD 1287
Query: 494 MDGTERKELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMG 553
++G R L S + H +G Q R++ R +K TG + V + +M
Sbjct: 1288 LNGANRHTLVS-PVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMD 1346
Query: 554 VKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC-VEPEAFLVY 612
++A PLG+N C NGGCSHLC RP + C CP G++L D KTC PE +L++
Sbjct: 1347 MQAVDRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLF 1406
Query: 613 SRKNIIGRLSIK-NEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSA 671
S + I R+S+ +++ D +P+ +L V +L K+Y++D I R +NGS
Sbjct: 1407 SSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSN 1466
Query: 672 VEKIV-EWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVL 730
+E ++ L +GLA+DW +N+YWTDT IE SRLDGS R+ +I L I
Sbjct: 1467 METVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLD---DIAA 1523
Query: 731 DPKKGYMYWSELGS-KSIKRAAMDGSSVSVFME-QVGRVHALAIDYERRAIYWAALDPPV 788
P+KGY++W++ G I+RA +DGS V + +G + L +DY+ R IYW
Sbjct: 1524 FPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDR 1583
Query: 789 VEFAFLNGTGRQTLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLD 848
+E A LNG RQ L ++ P+AL + +YW DW T IQ+ K G N++++ +++
Sbjct: 1584 IESADLNGKLRQVLVGHVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVE 1643
Query: 849 YISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACP 894
+ D+ + + G+N CGV+NGGC+HLC +D+ CACP
Sbjct: 1644 GLMDIIVVSPQRQTGTNACGVNNGGCTHLCFAR----ASDFVCACP 1685
Score = 502 bits (1239), Expect = e-141
Identities = 277/839 (33%), Positives = 438/839 (52%), Gaps = 28/839 (3%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDSPDFTP 326
CS C S + C C TG +LR + + P+ +L+ A R I ++ P +
Sbjct: 453 CSQGCTNSEG--AFQCWCETGYELRPDRRSCKALGPEPVLLFANRIDIRQVL---PHRSE 507
Query: 327 YTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGV--PDSIAI 384
YTL L +L+ + +DF + E ++W+D I +A L+GS+ VV S+G+ P +A+
Sbjct: 508 YTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVV-STGLESPGGLAV 566
Query: 385 DPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKP 444
D + K+YWTD I VA LDG++ KV++ L PRAIALH G ++W+DW P
Sbjct: 567 DWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWG-NTP 625
Query: 445 KIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHS 504
+IE +++DGSGR ++ L WPN + +D ++YW DA+ H IE N+DG+ RK + S
Sbjct: 626 RIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVIS 685
Query: 505 NDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFR-LGAPL 563
+ H F ++++ NK TG +++ + ++ M + P
Sbjct: 686 QGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPA 745
Query: 564 GWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGRLSI 623
G N C D+NGGC+HLC +Y C CP G + + FL+++R+ I R+S
Sbjct: 746 GKNRCGDNNGGCTHLCLPSGQNYTCACPTGFRKISSHACAQSLDKFLLFARRMDIRRISF 805
Query: 624 KNE-YNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEW-LGL 681
E +D VIP+ D++ AL +YW+D T TI+R +G+ E +V+ L
Sbjct: 806 DTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLES 865
Query: 682 VEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSE 741
GLAIDW +YWTD T RIEV+ DGS R +IW+ L +P+ IV++P GYMYW++
Sbjct: 866 PAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTD 925
Query: 742 LG-SKSIKRAAMDGSSVSVFM-EQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGR 799
G S I+RA MD S V + + + LAIDY + +YWA +EFA L+G+ R
Sbjct: 926 WGASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKR 985
Query: 800 QTL-ADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHR 858
+ L +P P+ L L+ + +YW DW T IQ A + G +R++++++L+ + D+ ++HR
Sbjct: 986 KVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHR 1045
Query: 859 AKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSE-PEEFLLFAQ 917
+ S C ++NGGCSHLCL +P + + C CP L D TCS FL+FA+
Sbjct: 1046 RRPPVSTPCAMENGGCSHLCLRSPNP--SGFSCTCPTGINLLSDGKTCSPGMNSFLIFAR 1103
Query: 918 KNAVGRIMVANGECNDAYIPLT-GLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXX 976
+ + + + D +P+ +KN A+ DP E ++YW D H I R +
Sbjct: 1104 RIDIRMVSLDIPYFADVVVPINITMKNTIAVGVDPQEGKVYWSDSTLHRISRANLD---- 1159
Query: 977 XXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLP 1036
GL + +D +GR +YWT + I ++D S V+V + P
Sbjct: 1160 -GSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLD-GSMRKVLVWQNLDSP 1217
Query: 1037 RHLAFHQTKRYLIWNDVGRGA-IMRANVDGTGRVELARADNA--TALALDQSAGTVYWA 1092
R + + ++ W D G A + R+ +DG+ R L + L +D+++ + WA
Sbjct: 1218 RAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWA 1276
Score = 302 bits (741), Expect = 5e-81
Identities = 176/539 (32%), Positives = 285/539 (52%), Gaps = 27/539 (5%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC--VEPEAFLVY-SRKNIIGRLS 622
N CA++ G CS C N + C C G EL D+++C + PE L++ +R +I L
Sbjct: 445 NECAEE-GYCSQGCTNSEGAFQCWCETGYELRPDRRSCKALGPEPVLLFANRIDIRQVLP 503
Query: 623 IKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVE-WLGL 681
++EY + + +L+ AL + ++WSD I R ++NGS VE++V L
Sbjct: 504 HRSEY---TLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLES 560
Query: 682 VEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSE 741
GLA+DW +YWTD+ T RIEV+ LDG+ R+ ++WQ L+KP++I L P +G +YW++
Sbjct: 561 PGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTD 620
Query: 742 LG-SKSIKRAAMDGSSVSVFME-QVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGR 799
G + I+ ++MDGS + + + + L IDY R +YW V+E A L+G+ R
Sbjct: 621 WGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHR 680
Query: 800 Q-TLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYH- 857
+ ++ +P P+A+ +F DS+YW DW+T I A K G N++ IR L + D+ H
Sbjct: 681 KAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHP 740
Query: 858 RAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQ 917
+ + G N+CG +NGGC+HLCLP+ +Y CACP +R + ++FLLFA+
Sbjct: 741 QRQPAGKNRCGDNNGGCTHLCLPS----GQNYTCACPTGFRKISSHACAQSLDKFLLFAR 796
Query: 918 KNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXX 977
+ + RI + +D IPL +++ A+++D + +YW D + +I R
Sbjct: 797 RMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISR-----AKWD 851
Query: 978 XXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPR 1037
L P + +D + +YWT A D I + D + T V++ + PR
Sbjct: 852 GTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRT-VLIWENLDRPR 910
Query: 1038 HLAFHQTKRYLIWNDVGRG-AIMRANVDGTGRVELARADNAT---ALALDQSAGTVYWA 1092
+ Y+ W D G I RA +D +GR ++ + N T LA+D + +YWA
Sbjct: 911 DIVVEPMGGYMYWTDWGASPKIERAGMDASGR-QVIISSNLTWPNGLAIDYGSQRLYWA 968
Score = 52.8 bits (121), Expect = 7e-06
Identities = 57/233 (24%), Positives = 83/233 (35%), Gaps = 20/233 (8%)
Query: 863 GSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL--FAQKNA 920
G C V+NGGC+ C G V +C C YRL +D TC + E + +
Sbjct: 402 GEENCNVNNGGCAQKCQMVRGAV----QCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGC 457
Query: 921 VGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXX 980
C Y ++ +A+ +PV +D IR+V
Sbjct: 458 TNSEGAFQCWCETGYELRPDRRSCKALGPEPVLLFANRID-----IRQVLPHRSEYTLLL 512
Query: 981 XXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLA 1040
L + L ++W+ D I ++ N S+ +V P LA
Sbjct: 513 NNLENAIALDFHHRREL------VFWSDVTLDRILRANL-NGSNVEEVVSTGLESPGGLA 565
Query: 1041 FHQTKRYLIWNDVGRGAIMRANVDGTGRVEL--ARADNATALALDQSAGTVYW 1091
L W D G I AN+DG R L + A+AL GT+YW
Sbjct: 566 VDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYW 618
Score = 46.4 bits (105), Expect = 6e-04
Identities = 31/96 (32%), Positives = 34/96 (35%), Gaps = 18/96 (18%)
Query: 1097 CDGQQDCEDGRDEAEC------------------GACGGDVRCADGTXXXXXXXXXXXXX 1138
CDG DC+DG DE C G C D+ DG
Sbjct: 215 CDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCS 274
Query: 1139 XXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
F CD GLCI A + CDG C D SDE
Sbjct: 275 SHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDE 310
Score = 46.0 bits (104), Expect = 8e-04
Identities = 25/85 (29%), Positives = 30/85 (35%), Gaps = 3/85 (3%)
Query: 1091 WAVSRQCDGQQDCEDGRDEAECGAC-GGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFR 1149
W+ C Q C G + G C RC DG + FR
Sbjct: 267 WSDESDCSSHQPCRSGEFMCDSGLCINAGWRC-DGDADCDDQSDERNCTTSMCTA-EQFR 324
Query: 1150 CDEGLCIAARFVCDGRPQCADGSDE 1174
C G C+ + CDG CAD SDE
Sbjct: 325 CHSGRCVRLSWRCDGEDDCADNSDE 349
Score = 42.7 bits (96), Expect = 0.008
Identities = 30/96 (31%), Positives = 38/96 (39%), Gaps = 23/96 (23%)
Query: 1093 VSRQCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDE 1152
+S +CDG+ DC D DE C G +CA D F C
Sbjct: 333 LSWRCDGEDDCADNSDEENCENTGSP-QCA----------------------LDQFLCWN 369
Query: 1153 GLCIAARFVCDGRPQCADGSDEAPAACAYGHTDQVN 1188
G CI R +C+G C D SDE+P T + N
Sbjct: 370 GRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEEN 405
Score = 42.3 bits (95), Expect = 0.010
Identities = 27/82 (32%), Positives = 34/82 (41%), Gaps = 5/82 (6%)
Query: 1095 RQC-DGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEG 1153
R+C D + C DG AE C GD C DG+ + F+C G
Sbjct: 194 RKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNL----EEFQCAYG 249
Query: 1154 LCIAARFVCDGRPQCADGSDEA 1175
CI + CDG C D SDE+
Sbjct: 250 RCILDIYHCDGDDDCGDWSDES 271
Score = 38.3 bits (85), Expect = 0.16
Identities = 28/92 (30%), Positives = 31/92 (33%), Gaps = 13/92 (14%)
Query: 1096 QCDGQQDCEDGRDEAEC--GACGG-DVRCADGTXXXXXXXXXXXXXXXXXXXX------- 1145
QCDG DC D DE C C D C +G
Sbjct: 98 QCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRE 157
Query: 1146 ---DAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
D F C G CI + + CDG C D SDE
Sbjct: 158 CEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDE 189
>AF176832-1|AAF70379.1| 4599|Homo sapiens low density lipoprotein
receptor related protein-deleted in tumor protein.
Length = 4599
Score = 493 bits (1216), Expect = e-138
Identities = 331/1119 (29%), Positives = 544/1119 (48%), Gaps = 68/1119 (6%)
Query: 17 LEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSE-GLVTPTGIAIDWYT 75
L A+DFH+ ++L+ W+D + I +E+ ++V E GL TP G+ +DW
Sbjct: 1287 LRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIA 1346
Query: 76 DKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDW-GEIPKIER 134
+YW D ++IEV + R L ++ RAIA+ P G++FWTDW P+IE
Sbjct: 1347 GNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIES 1406
Query: 135 AGMNGDPATRKVIVRD--NIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVK 192
A M+G A RK I +D WPNG+TVD+ I W DA+ + ++G +++
Sbjct: 1407 ASMSG--AGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIR 1464
Query: 193 GG--LVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESR 250
G L +PFA++ ++YWTDW+ ++ + G + + K+ P D+++Y SR
Sbjct: 1465 GHEYLSHPFAVSLYGSEVYWTDWRTNTLSKAN-KWTGQNVSVIQKTSAQPFDLQIYHPSR 1523
Query: 251 QIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQ 310
Q + CSH+CL++ + CACP +KL + T CY+ + LL A+
Sbjct: 1524 QPQAPNPCAANDGKGPCSHMCLINHNRSAA-CACPHLMKLSSDKKT-CYEMKKFLLY-AR 1580
Query: 311 RSTISKISLDSPDF---TPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGS 367
RS I + +D+P F T +T+P D+ +DFD E +YW D +TI +A ++G+
Sbjct: 1581 RSEIRGVDIDNPYFNFITAFTVP--DIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGT 1638
Query: 368 D-QSVVVRSSGVPDSIAIDPLSRKIYWTDPVMDT--INVARLDGSYEKVIIHTELYDPRA 424
++V+ R +A+D +SR +YW D INVARLDGS + IIH + P+
Sbjct: 1639 GLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSIIHG-IDKPQC 1697
Query: 425 IALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDA 484
+A H G ++W+D N I AN+DGS +L + P +++D V NKLYW +
Sbjct: 1698 LAAHPVRGKLYWTDGNT----INMANMDGSNSKILFQNQKE-PVGLSIDYVENKLYWISS 1752
Query: 485 RTHKIEVCNMDGTERKELHS--NDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQ 542
I CN+DG + + S ++ L +K G +
Sbjct: 1753 GNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPT 1812
Query: 543 PVVEQMANMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDY-ICGCPLGLELTADKK 601
+ + + ++ +K + A G N C +NGGCS LC + C C +G L ++
Sbjct: 1813 ILRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRM 1872
Query: 602 TCVEPEAFLVYSRKNIIGRLSIK-NEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTK 660
+C E+FL+YS I + ++ ++ DA++PI + + +YW+D
Sbjct: 1873 SCQGIESFLMYSVHEGIRGIPLEPSDKMDALMPISGTSFAVGIDFHAENDTIYWTDMGFN 1932
Query: 661 TINRCSVNGSAVEKIV-EWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIW 719
I+R + + E I+ LG VEG+A+DW NIYWTD IEV+RL+GS R II
Sbjct: 1933 KISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIIS 1992
Query: 720 QGLKKPKSIVLDPKKGYMYWSELGS-KSIKRAAMDGSSVSVFMEQ-VGRVHALAIDYERR 777
QGL +P+SI + P+KG ++W+E G I +A +DGS V + + + ++IDYE
Sbjct: 1993 QGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEEN 2052
Query: 778 AIYWAALDPPVVEFAFLNGTGRQTL---ADNIPMPYALALFNDSVYWGD--WNTGQIQQA 832
+YW +E L G + + N+ M +++A+F +YW D G +++
Sbjct: 2053 KLYWCDARTDKIERIDLETGGNREMVLSGSNVDM-FSVAVFGAYIYWSDRAHANGSVRRG 2111
Query: 833 RKTDGSNRKSIRKDLDY-ISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRC 891
K D + ++R L + ++K+++R + G+N C DNGGC LCL RT C
Sbjct: 2112 HKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLYRGNSRRT---C 2168
Query: 892 ACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVAN-GECNDAYIPLTG---LKNVRAI 947
AC AH L +D +TC E +LL++ + + I +++ N P KNV A+
Sbjct: 2169 AC-AHGYLAEDGVTCLRHEGYLLYSGRTILKSIHLSDETNLNSPIRPYENPRYFKNVIAL 2227
Query: 948 EYDPVEK-----QLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGR 1002
+D ++ ++++ D +I+ + ++ GL+ YH D
Sbjct: 2228 AFDYNQRRKGTNRIFYSDAHFGNIQLIKDNWEDRQVIVENVGSVEGLA--YHRAWD---- 2281
Query: 1003 TMYWTCADRDSINATSIDNN-----SSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVG--R 1055
T+YWT + SI ++D VI + P LA + + + W +
Sbjct: 2282 TLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQH 2341
Query: 1056 GAIMRANVDGTGRVELARADNAT--ALALDQSAGTVYWA 1092
+IMR+ + G + D T L +D A +Y++
Sbjct: 2342 PSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFS 2380
Score = 405 bits (996), Expect = e-112
Identities = 250/858 (29%), Positives = 407/858 (47%), Gaps = 42/858 (4%)
Query: 263 NNAGCSHLCLLSPDPPGYNCACPTGVKLR-ENSSTTCYDSPQMLLVVAQRSTISKISLDS 321
N+ CS +C C+C G KL + S T D + ++ + R I +I L
Sbjct: 1220 NHLKCSQVC--EQHKHTVKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHK 1277
Query: 322 PDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSD-----QSVVVRSS 376
D Y+L + L+ T+ +DF +YW D + I + +L S + VV
Sbjct: 1278 RD---YSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGL 1334
Query: 377 GVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFW 436
P+ + +D ++ IYW D +D I VA+LDGS +I + PRAIAL G +FW
Sbjct: 1335 ATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFW 1394
Query: 437 SDWNEKKPKIERANLDGSGRVLLISEKLT--WPNSIALDTVNNKLYWGDARTHKIEVCNM 494
+DW+ P+IE A++ G+GR + + T WPN + +D ++ W DAR+ I
Sbjct: 1395 TDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALY 1454
Query: 495 DGTERKELHSND--IIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMM 552
DGT E+ + H F + TL + NK TG + + + A
Sbjct: 1455 DGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPF 1514
Query: 553 GVKAFRLG-APLGWNPCA--DDNGGCSHLC-FNRPDDYICGCPLGLELTADKKTCVEPEA 608
++ + P NPCA D G CSH+C N C CP ++L++DKKTC E +
Sbjct: 1515 DLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACPHLMKLSSDKKTCYEMKK 1574
Query: 609 FLVYSRKNIIGRLSIKNEYNDAV--IPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCS 666
FL+Y+R++ I + I N Y + + + D+ +V+ + S +LYW+D KT+TI R
Sbjct: 1575 FLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAF 1634
Query: 667 VNGSAVEKIVEW-LGLVEGLAIDWSGQNIYW--TDTTTQRIEVSRLDGSSRRAIIWQGLK 723
+NG+ +E ++ + + GLA+DW +N+YW ++ +I V+RLDGS + +II G+
Sbjct: 1635 INGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSII-HGID 1693
Query: 724 KPKSIVLDPKKGYMYWSELGSKSIKRAAMDGSSVSVFMEQVGRVHALAIDYERRAIYWAA 783
KP+ + P +G +YW++ +I A MDGS+ + + L+IDY +YW +
Sbjct: 1694 KPQCLAAHPVRGKLYWTD--GNTINMANMDGSNSKILFQNQKEPVGLSIDYVENKLYWIS 1751
Query: 784 LDPPVVEFAFLNGTGR---QTLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNR 840
+ L+G +++ + + AL + + ++W D N Q+ K DG N
Sbjct: 1752 SGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNP 1811
Query: 841 KSIRKDLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLN 900
+R + +K+Y + GSN C ++NGGCS LCLPT RT C C Y L
Sbjct: 1812 TILRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLCLPTSETTRT---CMCTVGYYLQ 1868
Query: 901 KDNITCSEPEEFLLFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMD 960
K+ ++C E FL+++ + I + + DA +P++G I++ +YW D
Sbjct: 1869 KNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMDALMPISGTSFAVGIDFHAENDTIYWTD 1928
Query: 961 DDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSID 1020
+ I R GL R + +D + +YWT + I +
Sbjct: 1929 MGFNKISR-----AKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARL- 1982
Query: 1021 NNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGR-GAIMRANVDGTGRVELARADNA-- 1077
N S VI+ PR +A H K L W + G+ I +A +DG+ +V L A
Sbjct: 1983 NGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWP 2042
Query: 1078 TALALDQSAGTVYWAVSR 1095
+++D +YW +R
Sbjct: 2043 NGISIDYEENKLYWCDAR 2060
Score = 355 bits (874), Expect = 4e-97
Identities = 267/961 (27%), Positives = 449/961 (46%), Gaps = 58/961 (6%)
Query: 16 DLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAIDWYT 75
D++ T +DF + + W+D K + I+ N T G + ++S + + G+A+DW +
Sbjct: 1604 DIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGT--GLE-TVISRDIQSIRGLAVDWVS 1660
Query: 76 DKLYWTDGETNKIEV-ISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIER 134
LYW E ++ ++ ++ + K +D + +A P G ++WTD I
Sbjct: 1661 RNLYWISSEFDETQINVARLDGSLKTSIIHGIDKPQCLAAHPVRGKLYWTDGNTI---NM 1717
Query: 135 AGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRV--VK 192
A M+G + I+ N P G+++DY + +YW+ + ++ + +G + + +K
Sbjct: 1718 ANMDG---SNSKILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMK 1774
Query: 193 GGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESRQI 252
L ALT + KL+W D QN + +G L +KVYD+ Q
Sbjct: 1775 EELTKATALTIMDKKLWWAD-QNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQ 1833
Query: 253 ISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRS 312
S C+ NN GCS LCL + + C C G L++N + C + L+ +
Sbjct: 1834 GSNS---CQLNNGGCSQLCLPTSETTR-TCMCTVGYYLQKNRMS-C-QGIESFLMYSVHE 1887
Query: 313 TISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGS-DQSV 371
I I L+ D +P+ + +DF + + IYW D IS+A+ D + + +
Sbjct: 1888 GIRGIPLEPSDKMDALMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDI 1947
Query: 372 VVRSSGVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTA 431
+ G + IA+D ++ IYWTD + I VARL+GS+ VII L PR+IA+H
Sbjct: 1948 ITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEK 2007
Query: 432 GWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEV 491
G +FW++W + P I +A LDGS +V+L+S + WPN I++D NKLYW DART KIE
Sbjct: 2008 GLLFWTEWGQM-PCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIER 2066
Query: 492 CNMD-GTERKELHSNDIIHIFGXXXXXXXX--XXXXMQKRTLDRINKNTGLDRQPVVEQM 548
+++ G R+ + S + +F ++ R +KN + + +
Sbjct: 2067 IDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETITMRTGL 2126
Query: 549 A-NMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDY-ICGCPLGLELTADKKTCVEP 606
N+ VK F G N CA DNGGC LC R + C C G L D TC+
Sbjct: 2127 GVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLYRGNSRRTCACAHGY-LAEDGVTCLRH 2185
Query: 607 EAFLVYSRKNIIGRLSIKNE--YNDAVIPIKD---LKEVSALALYVSG-----SKLYWSD 656
E +L+YS + I+ + + +E N + P ++ K V ALA + +++++SD
Sbjct: 2186 EGYLLYSGRTILKSIHLSDETNLNSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSD 2245
Query: 657 SKTKTINRCSVNGSAVEKIVEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGS---- 712
+ I N + IVE +G VEGLA + +YWT +TT I +D +
Sbjct: 2246 AHFGNIQLIKDNWEDRQVIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGA 2305
Query: 713 -SRRAIIWQGLKK-PKSIVLDPKKGYMYWSELGSK--SIKRAAMDGSSVSVFME-QVGRV 767
R A+I P + LD + M+W+ + SI R+ + G + V + +
Sbjct: 2306 FDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTP 2365
Query: 768 HALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPMPY-ALALFNDSVYWGDWNT 826
+ L IDY +Y++ +E +G+ R + + P + +LA++++ ++W DW
Sbjct: 2366 NGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGR 2425
Query: 827 GQIQQARKTDGSNRKSIRKDLDY--ISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGD 884
I ++ K G + K +R D+ + + + + + S + C + NGGC LCL TP
Sbjct: 2426 RAILRSNKYTGGDTKILRSDIPHQPMGIIAVANDTNSCELSPCALLNGGCHDLCLLTPNG 2485
Query: 885 VRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVANGECNDAYIPLTGLKNV 944
C+C L +DN ++ + NA NGEC D + G+ +
Sbjct: 2486 ---RVNCSCRGDRILLEDNRCVTKN------SSCNAYSEFECGNGECIDYQLTCDGIPHC 2536
Query: 945 R 945
+
Sbjct: 2537 K 2537
Score = 267 bits (654), Expect = 2e-70
Identities = 175/602 (29%), Positives = 293/602 (48%), Gaps = 27/602 (4%)
Query: 23 VDFHYRKNLICW--SDQKPELIQCMNYNET--YTGEKFKIVSEGLVTPTGIAIDWYTDKL 78
+DF Y +++ICW S + ++C+ + T E + + +AIDW T L
Sbjct: 238 LDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNL 297
Query: 79 YWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERAGMN 138
Y+ D ++I V + L E+ +AIAV P G +F+TD+G + K+ER M+
Sbjct: 298 YFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMD 357
Query: 139 GDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVKGGLV-Y 197
G TR I+ P + +D N L+YWVD L +V V+D+ G+ R V++G V +
Sbjct: 358 GMNRTR--IIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGKNRHTVIQGRQVRH 415
Query: 198 PFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESRQIISAED 257
+ +T D LY T+ N++I + NG I LIK I++Y + Q +
Sbjct: 416 LYGITVFEDYLYATNSDNYNIVRIN-RFNGTDIHSLIKIENAWG-IRIYQKRTQP-TVRS 472
Query: 258 YPCKKNN----AGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQR-- 311
+ C+ + GCSH+CLLS C C TG L + + ++ L +
Sbjct: 473 HACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRPKNELFLFYGKGRP 532
Query: 312 STISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSV 371
+ + L++ Y +P+++L +DF +T YIY+AD + I + ++DG+++
Sbjct: 533 GIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGTERET 592
Query: 372 VVRSS-GVPDSIAIDPLSRKIYWT-DPVMDTINVARLDGSYE--KVIIHTELYDPRAIAL 427
+++ + IA+D + +YWT D TINVARL+ + + K ++ E+ PR I +
Sbjct: 593 ILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVV 652
Query: 428 HLTAGWMFWSDWNEKK-----PKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWG 482
GWM+W+DW E + +IE+A +DG R + ++ K+ WPN + LD N LYW
Sbjct: 653 DPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWC 712
Query: 483 DARTHKIEVCNMDGTERKELHS-NDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDR 541
DA IE ++GT RK ++S ++ H FG ++ +++ T +
Sbjct: 713 DAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDLITS-EV 771
Query: 542 QPVVEQMANMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKK 601
+ + + G++ + G N C +NGGCS LC P +C C L +
Sbjct: 772 TLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGT 831
Query: 602 TC 603
TC
Sbjct: 832 TC 833
Score = 256 bits (626), Expect = 5e-67
Identities = 214/776 (27%), Positives = 353/776 (45%), Gaps = 59/776 (7%)
Query: 205 NDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESRQIISAEDYPCKKNN 264
N L D + ++ ++ +N ++ K V + Y E I+ + CK +
Sbjct: 98 NGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQD 157
Query: 265 -----AGCSHLCLLSPDPPGYNCACPTGVKLR-ENSSTTCYDSPQ---MLLVVAQRSTIS 315
CS C + Y C+C G ++ +N S P +L++A TI
Sbjct: 158 ECAVYGTCSQTCRNTHG--SYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIE 215
Query: 316 KISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLA-----KTISKARLDG-SDQ 369
L+ TL + T+DF + I W + K I + G +D+
Sbjct: 216 VFYLNGSKMA--TLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDE 273
Query: 370 SVV--VRSSGVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIAL 427
+ ++S +AID L+R +Y+ D V D I V +GS +I EL++P+AIA+
Sbjct: 274 WTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAV 333
Query: 428 HLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTH 487
AG +F++D+ K+ER ++DG R +I K P ++ALD VN +YW D
Sbjct: 334 DPIAGKLFFTDYGNVA-KVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLD 392
Query: 488 KIEVCNMDGTERKE-LHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVE 546
+ V + G R + + H++G + RIN+ G D +++
Sbjct: 393 YVGVVDYQGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIK 452
Query: 547 QMANMMGVKAF--RLGAPLGWNPCADDN----GGCSHLCF--NRPDDYICGCPLGLELTA 598
+ N G++ + R + + C D GGCSH+C + C C G L +
Sbjct: 453 -IENAWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGS 511
Query: 599 DKKTCVEP--EAFLVYS--RKNIIGRLSIKNEYNDA-VIPIKDLKEVSALALYVSGSKLY 653
D ++C P E FL Y R I+ + + + D +IPI++L AL + + +Y
Sbjct: 512 DGRSCKRPKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIY 571
Query: 654 WSDSKTKTINRCSVNGSAVEKIV-EWLGLVEGLAIDWSGQNIYWT-DTTTQRIEVSRLD- 710
++D+ + I R ++G+ E I+ + L VEG+A+DW G N+YWT D + I V+RL+
Sbjct: 572 FADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEK 631
Query: 711 -GSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKSI-------KRAAMDGSSVSVFM- 761
SR+ ++ + P+ IV+DP G+MYW++ I ++A MDG + +F+
Sbjct: 632 ASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVT 691
Query: 762 EQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPM--PYALALFNDSV 819
++ + L +D+ +YW +E FLNGT R+ + + P+ L+ + V
Sbjct: 692 SKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYV 751
Query: 820 YWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCL 879
+W D+ G I Q S +R + + L++Y K G N C V+NGGCS LCL
Sbjct: 752 FWTDYMNGSIFQLDLIT-SEVTLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCL 810
Query: 880 PTPGDVRTDYRCACPAHYRLNKDNITCS-EPEEFLLFAQKNAVGRIMVANGECNDA 934
PG R CAC + L+++ TC+ P E L K G N C A
Sbjct: 811 AIPGG-RV---CACADNQLLDENGTTCTFNPGEALPHICK--AGEFRCKNRHCIQA 860
Score = 211 bits (516), Expect = 1e-53
Identities = 124/344 (36%), Positives = 188/344 (54%), Gaps = 20/344 (5%)
Query: 575 CSHLCFNRPDDYICGCPLGLELTADK----KTCVEPEAFLVYSRKNIIGRLSIKNEYNDA 630
CS C N Y C C G E+ D K+ + E FL+ + + I ++S + ++
Sbjct: 2978 CSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKIS--TDGSNY 3035
Query: 631 VIPIKDLKEVSALALYVSGSKLYWSDSKTKT---INRCSVNGSAVEKIVEWLGLVEGLAI 687
+ + L V A+ +YW DS INR +NGS + K+V + LA+
Sbjct: 3036 TLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDI-KVVHNTAVPNALAV 3094
Query: 688 DWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGS-KS 746
DW G+N+YW+DT + IEVS+L+G ++ + LK P+ + LDP+ GY+YW +
Sbjct: 3095 DWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPH 3154
Query: 747 IKRAAMDGSSVSVFME-QVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLAD- 804
I R MDG++ SV +E ++ R AL IDY R +YWA D +EF+ ++G+ R + +
Sbjct: 3155 IGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWA--DENHIEFSNMDGSHRHKVPNQ 3212
Query: 805 NIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYH--RAKSM 862
+IP AL LF D +YW D T + +A KT G++R S+ I+D+++YH R +
Sbjct: 3213 DIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDV 3272
Query: 863 GSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
+ C ++NGGCSHLCL PG T CACP ++ L DN TC
Sbjct: 3273 SKHLCMINNGGCSHLCLLAPGKTHT---CACPTNFYLAADNRTC 3313
Score = 182 bits (443), Expect = 7e-45
Identities = 103/346 (29%), Positives = 177/346 (51%), Gaps = 17/346 (4%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLRENSSTTC--YDSPQMLLVVAQRSTISKISLDSPDF 324
CS C+ + Y C C G +++ ++ C + L++A I KIS D +
Sbjct: 2978 CSQQCINTYGT--YKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSN- 3034
Query: 325 TPYTLPLKDLKRTLTVDFDPKTEYIYWADGL---AKTISKARLDGSDQSVVVRSSGVPDS 381
YTL + L + +DFD + E+IYW D I++ L+GSD VV ++ VP++
Sbjct: 3035 --YTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVV-HNTAVPNA 3091
Query: 382 IAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNE 441
+A+D + + +YW+D I V++L+G Y +++ L PR ++L AG+++W D E
Sbjct: 3092 LAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCE 3151
Query: 442 KKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKE 501
P I R +DG+ + ++I K++ P ++ +D VN +LYW D + IE NMDG+ R +
Sbjct: 3152 -YPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWAD--ENHIEFSNMDGSHRHK 3208
Query: 502 LHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFR--L 559
+ + DI + + ++L R +K +G DR ++ + ++ +
Sbjct: 3209 VPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYR 3268
Query: 560 GAPLGWNPCADDNGGCSHLCFNRP-DDYICGCPLGLELTADKKTCV 604
+ + C +NGGCSHLC P + C CP L AD +TC+
Sbjct: 3269 QPDVSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTCL 3314
Score = 151 bits (367), Expect = 1e-35
Identities = 89/286 (31%), Positives = 134/286 (46%), Gaps = 9/286 (3%)
Query: 11 TTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIA 70
T + + L A+DF YR+ I W D +N G K+V V P +A
Sbjct: 3036 TLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRIN-RMCLNGSDIKVVHNTAV-PNALA 3093
Query: 71 IDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIP 130
+DW LYW+D E IEV + Y +L + R +++ P+ G ++W D E P
Sbjct: 3094 VDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYP 3153
Query: 131 KIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRV 190
I R GM+G + V++ I P +T+DY N +YW D ++ + +G R +V
Sbjct: 3154 HIGRVGMDG--TNQSVVIETKISRPMALTIDYVNRRLYWADE--NHIEFSNMDGSHRHKV 3209
Query: 191 VKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESR 250
+ ALT D +YWTD + S+ + ++ + H + DI+VY R
Sbjct: 3210 PNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAI-TDIQVYHSYR 3268
Query: 251 QIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSST 296
Q + C NN GCSHLCLL+P + CACPT L ++ T
Sbjct: 3269 Q-PDVSKHLCMINNGGCSHLCLLAPGKT-HTCACPTNFYLAADNRT 3312
Score = 141 bits (342), Expect = 1e-32
Identities = 141/559 (25%), Positives = 232/559 (41%), Gaps = 50/559 (8%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTC---VEPE---AFLVYSRKNIIGRLSIKNE 626
G CS C N Y C C G + D ++C +EP L+ + I + N
Sbjct: 163 GTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETI-EVFYLNG 221
Query: 627 YNDAVIPIKDLKEVSALALYVSGSKLYWSDSKT-----KTINRCSVNGSAVE---KIVEW 678
A + + E+ L + + W +S+ K I G E I++
Sbjct: 222 SKMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQS 281
Query: 679 LGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMY 738
V+ +AIDW +N+Y+ D RI V +GS +I L PK+I +DP G ++
Sbjct: 282 FHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLF 341
Query: 739 WSELGS-KSIKRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNG 796
+++ G+ ++R MDG + + + + ALA+D + +YW L V G
Sbjct: 342 FTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQG 401
Query: 797 TGRQTLAD--NIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLK 854
R T+ + Y + +F D +Y + + I + + +G++ S+ K ++ ++
Sbjct: 402 KNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIK-IENAWGIR 460
Query: 855 LYHR--AKSMGSNQCGVD----NGGCSHLCLPTPG-DVRTDYRCACPAHYRLNKDNITCS 907
+Y + ++ S+ C VD GGCSH+CL + RT C C + L D +C
Sbjct: 461 IYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRT---CRCRTGFNLGSDGRSCK 517
Query: 908 EPE-EFLLFAQKNAVG--RIMVANGECNDAY-IPLTGLKNVRAIEYDPVEKQLYWMDDDS 963
P+ E LF K G R M N + D Y IP+ L N RA+++ +Y+ D S
Sbjct: 518 RPKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTS 577
Query: 964 HSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWT-CADRDSINATSIDNN 1022
I R I L + +D +G +YWT R +IN ++
Sbjct: 578 FLIGRQKID-----GTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKA 632
Query: 1023 S-STGVIVRGDRMLPRHLAFHQTKRYLIWNDVGR-------GAIMRANVDGTGRVELARA 1074
S S ++ G+ PR + ++ W D G I +A +DG R +
Sbjct: 633 SQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTS 692
Query: 1075 DN--ATALALDQSAGTVYW 1091
L LD T+YW
Sbjct: 693 KMLWPNGLTLDFHTNTLYW 711
Score = 89.4 bits (212), Expect = 7e-17
Identities = 86/362 (23%), Positives = 151/362 (41%), Gaps = 43/362 (11%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTCV----EPEAFLVYSRKNIIGRLSIKNEYN 628
G CSH C N Y C C + TC+ E + + + +I+G + N
Sbjct: 3852 GTCSHQCINVEGSYKCVCDQNFQ--ERNNTCIAEGSEDQVLYIANDTDILGFIYPFNYSG 3909
Query: 629 D--AVIPIKDLKEVSALALYVSGSKLYWSDS-KTKTINRCSVNGSAVEKIVEWLGLVE-- 683
D + I+ ++ + +Y + WS I ++G + L E
Sbjct: 3910 DHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFK 3969
Query: 684 ---GLAIDWSGQNIYWTDTTTQR---------------IEVSRLDGSSRRAIIWQGLKKP 725
+A+DW NIYWTD + I V +L+G + ++ +P
Sbjct: 3970 RPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEP 4029
Query: 726 KSIVLDPKKGYMYWSELGSKS-IKRAAMDGSSVSVFMEQ-VGRVHALAIDYERRAIYWAA 783
+I ++PK+G MYW+ +G S I+ AAMDG+ + +++ + R LA+DY IYWA
Sbjct: 4030 YAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWAD 4089
Query: 784 LDPPVVEFAFLNGTGRQTLADN---IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNR 840
+ ++ +G+ + + P+ + +F D +Y G + + +K +
Sbjct: 4090 FELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKNG-VFRVQKFGHGSV 4148
Query: 841 KSIRKDLDYISDLKLYHRAKSMG-SNQCGVDNGGCSHLCLPTPGDVRTDYRCACP-AHYR 898
+ + ++D + + HR K + N C +D C LCL P C CP Y
Sbjct: 4149 EYLALNIDKTKGVLISHRYKQLDLPNPC-LDL-ACEFLCLLNPSGA----TCVCPEGKYL 4202
Query: 899 LN 900
+N
Sbjct: 4203 IN 4204
Score = 89.4 bits (212), Expect = 7e-17
Identities = 79/290 (27%), Positives = 127/290 (43%), Gaps = 37/290 (12%)
Query: 21 TAVDFHYRKNLICWSDQ-KPELIQCMNYNETYTGEKFKIVSEGLVTPT-----GIAIDWY 74
T +D +Y++++I WS Q P I Y + EK + + GL+ P IA+DW
Sbjct: 3924 TGMDVYYQRDMIIWSTQFNPGGIF---YKRIHGREK-RQANSGLICPEFKRPRDIAVDWV 3979
Query: 75 TDKLYWTDGETN---------------KIEVISIVQKYRKVLFWSEVDLARAIAVVPEDG 119
+YWTD I V + L + AIAV P+ G
Sbjct: 3980 AGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRG 4039
Query: 120 LMFWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDV 179
+M+WT G+ IE A M+G R+++V+ N+ P G+ VDY + IYW D +L +
Sbjct: 4040 MMYWTVVGDHSHIEEAAMDG--TLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGS 4097
Query: 180 IDFNGEKRKRVV--KGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSH 237
+ ++G V K GL++P + D +Y +N ++ +G ++ L +
Sbjct: 4098 VLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKN-GVFRVQKFGHG-SVEYLALNI 4155
Query: 238 PVPADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTG 287
+ + +Q+ D P + C LCLL+P G C CP G
Sbjct: 4156 DKTKGVLISHRYKQL----DLPNPCLDLACEFLCLLNPS--GATCVCPEG 4199
Score = 84.6 bits (200), Expect = 2e-15
Identities = 75/255 (29%), Positives = 120/255 (47%), Gaps = 19/255 (7%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKL-RENSSTTCYDSPQMLLVVAQRSTISKIS 318
C NN GCS+ C + P G C+CP G++L ++N + D L +Q K +
Sbjct: 1176 CSLNNGGCSNHCSVVPG-RGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHT 1234
Query: 319 LDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGV 378
+ + + L D+ DP +I ++ + I + L D S++V G+
Sbjct: 1235 VKCSCYEGWKL---DVDGESCTSVDPFEAFIIFS--IRHEIRRIDLHKRDYSLLV--PGL 1287
Query: 379 PDSIAIDPLSRK--IYWTDPVMDTINVARLDG----SYEKVIIHTELYDPRAIALHLTAG 432
++IA+D + +YWTD V D I +L S +V++ L P + + AG
Sbjct: 1288 RNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAG 1347
Query: 433 WMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYW--GDARTHKIE 490
++W D N +IE A LDGS R LI+ + P +IALD L+W DA +IE
Sbjct: 1348 NIYWIDSN--LDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIE 1405
Query: 491 VCNMDGTERKELHSN 505
+M G RK ++ +
Sbjct: 1406 SASMSGAGRKTIYKD 1420
Score = 75.8 bits (178), Expect = 9e-13
Identities = 73/297 (24%), Positives = 126/297 (42%), Gaps = 15/297 (5%)
Query: 568 CADDNGGCSHLCFNRPD-DYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGRLSIKNE 626
C+ +NGGCS+ C P +C CP GL+L D KTC + + + + + K+
Sbjct: 1176 CSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCE-QHKHT 1234
Query: 627 YNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVEGLA 686
+ L V + + S I R ++ +V L L
Sbjct: 1235 VKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALD 1294
Query: 687 IDWSGQNIYWTDTTTQRI---EVSRLDG-SSRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
++ +YWTD RI ++S G S+ ++ GL P+ + +D G +YW +
Sbjct: 1295 FHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDS 1354
Query: 743 GSKSIKRAAMDGS-SVSVFMEQVGRVHALAIDYERRAIYWAALDP--PVVEFAFLNGTGR 799
I+ A +DGS ++ + A+A+D ++W D P +E A ++G GR
Sbjct: 1355 NLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGR 1414
Query: 800 QTLADNI---PMPYALAL--FNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYIS 851
+T+ ++ P L + F + W D + I A DG+N I + +Y+S
Sbjct: 1415 KTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSA-LYDGTNMIEIIRGHEYLS 1470
Score = 66.5 bits (155), Expect = 5e-10
Identities = 57/226 (25%), Positives = 96/226 (42%), Gaps = 19/226 (8%)
Query: 874 CSHLCLPTPGDVRTDYRCACPAHYRLNKDNIT-C---SEPEEFLLFAQKNAVGRIMVANG 929
CS C+ T G Y+C C Y + DN C S+ E FL+ A + + +I
Sbjct: 2978 CSQQCINTYGT----YKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKIST--- 3030
Query: 930 ECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGL 989
+ ++ + GL NV AI++D E+ +YW+D + R+
Sbjct: 3031 DGSNYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRI----NRMCLNGSDIKVVHNT 3086
Query: 990 SRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLI 1049
+ P + +D +G+ +YW+ ++ I + ++ T ++V PR L+ YL
Sbjct: 3087 AVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPT-ILVSKRLKFPRDLSLDPQAGYLY 3145
Query: 1050 WNDVGR-GAIMRANVDGTGR--VELARADNATALALDQSAGTVYWA 1092
W D I R +DGT + V + AL +D +YWA
Sbjct: 3146 WIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWA 3191
Score = 62.5 bits (145), Expect = 9e-09
Identities = 43/146 (29%), Positives = 68/146 (46%), Gaps = 8/146 (5%)
Query: 9 RITTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTG 68
R I++ L+Q ++ H K L+ W++ + C+ EK +VS G+ P G
Sbjct: 1987 RYVIISQGLDQPRSIAVHPEKGLLFWTEWGQ--MPCIGKARLDGSEKVVLVSMGIAWPNG 2044
Query: 69 IAIDWYTDKLYWTDGETNKIEVISIVQ--KYRKVLFWSEVDLARAIAVVPEDGLMFWTDW 126
I+ID+ +KLYW D T+KIE I + VL S VD+ +V ++W+D
Sbjct: 2045 ISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDM---FSVAVFGAYIYWSDR 2101
Query: 127 GEIPKIERAGMNGDPATRKVIVRDNI 152
R G D AT + +R +
Sbjct: 2102 AHANGSVRRGHKND-ATETITMRTGL 2126
Score = 58.8 bits (136), Expect = 1e-07
Identities = 72/304 (23%), Positives = 129/304 (42%), Gaps = 21/304 (6%)
Query: 566 NPCADDN-GGCSHLCFNRPDDYICGCPLGLELTADKKTCV---EPEAFLVYSRKNIIGRL 621
N C GCS C + P Y C C G +L D KTCV E + S++ I
Sbjct: 2928 NECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYG 2987
Query: 622 SIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGL 681
+ K D I+ +L L +D I + S +GS + + L
Sbjct: 2988 TYKCLCTDG-YEIQPDNPNGCKSLSDEEPFLILADH--HEIRKISTDGSNYTLLKQGLNN 3044
Query: 682 VEGLAIDWSGQNIYWTDTTT---QRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMY 738
V + D+ + IYW D++ RI L+GS + + P ++ +D +Y
Sbjct: 3045 VIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVV--HNTAVPNALAVDWIGKNLY 3102
Query: 739 WSELGSKSIKRAAMDGSSVSVFM-EQVGRVHALAIDYERRAIYWA-ALDPPVVEFAFLNG 796
WS+ + I+ + ++G ++ + +++ L++D + +YW + P + ++G
Sbjct: 3103 WSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDG 3162
Query: 797 TGRQTLAD-NIPMPYALAL--FNDSVYWGDWNTGQIQQARKTDGSNRKSI-RKDLDYISD 852
T + + + I P AL + N +YW D N + DGS+R + +D+ +
Sbjct: 3163 TNQSVVIETKISRPMALTIDYVNRRLYWADENHIEFS---NMDGSHRHKVPNQDIPGVIA 3219
Query: 853 LKLY 856
L L+
Sbjct: 3220 LTLF 3223
Score = 58.4 bits (135), Expect = 1e-07
Identities = 64/253 (25%), Positives = 89/253 (35%), Gaps = 20/253 (7%)
Query: 941 LKNVRAIEYDPVEKQLYWMD----DDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMV 996
+ + R I DPV +YW D + S+ R+ ++ + P +
Sbjct: 644 MSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSK--MLWPNGLT 701
Query: 997 LDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRG 1056
LD T+YW A D I + N + IV R L Y+ W D G
Sbjct: 702 LDFHTNTLYWCDAYYDHIEKVFL--NGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMNG 759
Query: 1057 AIMRANVDGTGRVELARADNATALALDQSAGTVYWAVSRQCDGQQDCEDGRDEAECGAC- 1115
+I + ++ T V L R + L +Y +Q D +G C A
Sbjct: 760 SIFQLDLI-TSEVTLLRHERPPLFGLQ-----IYDPRKQQGDNMCRVNNGGCSTLCLAIP 813
Query: 1116 GGDV-RCADGTXXXXXXXXXXXXXXXXXXX---XDAFRCDEGLCIAARFVCDGRPQCADG 1171
GG V CAD FRC CI AR+ CDG C DG
Sbjct: 814 GGRVCACADNQLLDENGTTCTFNPGEALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDG 873
Query: 1172 SDEAPAACAYGHT 1184
SDE C + H+
Sbjct: 874 SDEDSVNC-FNHS 885
Score = 55.6 bits (128), Expect = 1e-06
Identities = 77/352 (21%), Positives = 129/352 (36%), Gaps = 31/352 (8%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKI-SLDSPDFT 325
CSH C+ Y C C + R N+ Q+L + + I +
Sbjct: 3854 CSHQCINVEG--SYKCVCDQNFQERNNTCIAEGSEDQVLYIANDTDILGFIYPFNYSGDH 3911
Query: 326 PYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKT-ISKARLDGSDQ-----SVVVRSSGVP 379
++ R +D + + I W+ I R+ G ++ ++ P
Sbjct: 3912 QQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFKRP 3971
Query: 380 DSIAIDPLSRKIYWTD---------------PVMDTINVARLDGSYEKVIIHTELYDPRA 424
IA+D ++ IYWTD + +INV +L+G ++ +P A
Sbjct: 3972 RDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYA 4031
Query: 425 IALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDA 484
IA++ G M+W+ + IE A +DG+ R +L+ + L P +A+D + ++YW D
Sbjct: 4032 IAVNPKRGMMYWTVVGDHS-HIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADF 4090
Query: 485 RTHKIEVCNMDGTERKELHSN--DIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQ 542
I DG+ S+ ++H K + R+ K +
Sbjct: 4091 ELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAG-PKNGVFRVQKFGHGSVE 4149
Query: 543 PVVEQMANMMGVKAFRLGAPLGW-NPCADDNGGCSHLCFNRPDDYICGCPLG 593
+ + GV L NPC D C LC P C CP G
Sbjct: 4150 YLALNIDKTKGVLISHRYKQLDLPNPCLD--LACEFLCLLNPSGATCVCPEG 4199
Score = 52.8 bits (121), Expect = 7e-06
Identities = 54/232 (23%), Positives = 86/232 (37%), Gaps = 16/232 (6%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRI 924
++C ++NGGCS+ C PG C+CP +LNKDN TC + + + V
Sbjct: 1174 DECSLNNGGCSNHCSVVPG---RGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQ 1230
Query: 925 MVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXX 984
+C+ + DP E + + H IRR+ +
Sbjct: 1231 HKHTVKCSCYEGWKLDVDGESCTSVDPFEAFIIF--SIRHEIRRIDLHKRDYSLLVPGLR 1288
Query: 985 XXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNN---SSTGVIVRGDRMLPRHLAF 1041
L ++ L +YWT D I + + S+ V+V P L
Sbjct: 1289 NTIALDFHFNQSL------LYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTV 1342
Query: 1042 HQTKRYLIWNDVGRGAIMRANVDGTGRVEL--ARADNATALALDQSAGTVYW 1091
+ W D I A +DG+ R L ++ A+ALD G ++W
Sbjct: 1343 DWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFW 1394
Score = 52.8 bits (121), Expect = 7e-06
Identities = 44/187 (23%), Positives = 90/187 (48%), Gaps = 14/187 (7%)
Query: 35 SDQKPELIQCMNYNE---TYTGEKFKIVSEGLVTPTGIAIDWYTDKLYWTDGET---NKI 88
SD++P LI ++ + G + ++ +GL I D+ + +YW D ++I
Sbjct: 3011 SDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRI 3070
Query: 89 EVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERAGMNGDPATRKVIV 148
+ + KV+ + V A A+ + ++ ++W+D E IE + +NG T ++V
Sbjct: 3071 NRMCLNGSDIKVVHNTAVPNALAVDWIGKN--LYWSD-TEKRIIEVSKLNGLYPT--ILV 3125
Query: 149 RDNIFWPNGITVDYNNSLIYWVD-AKLQFVDVIDFNGEKRKRVVKGGLVYPFALT--FSN 205
+ +P +++D +YW+D + + + +G + V++ + P ALT + N
Sbjct: 3126 SKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVN 3185
Query: 206 DKLYWTD 212
+LYW D
Sbjct: 3186 RRLYWAD 3192
Score = 50.4 bits (115), Expect = 4e-05
Identities = 29/85 (34%), Positives = 37/85 (43%), Gaps = 23/85 (27%)
Query: 1097 CDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCI 1156
CDG++DC DG DE C + C + +AF C +CI
Sbjct: 2781 CDGERDCPDGSDELSTAGCAPNNTCDE----------------------NAFMCHNKVCI 2818
Query: 1157 AARFVCDGRPQCADGSDEAPAACAY 1181
+FVCD C DGSDE+P C Y
Sbjct: 2819 PKQFVCDHDDDCGDGSDESP-QCGY 2842
Score = 50.0 bits (114), Expect = 5e-05
Identities = 36/114 (31%), Positives = 44/114 (38%), Gaps = 28/114 (24%)
Query: 1097 CDGQQDCEDGRDEAECGA--------------------CGGDVRCADGTXXXXXXXXXXX 1136
CDGQ+DCEDGRDE C + C G+ C DG
Sbjct: 2701 CDGQKDCEDGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAIT 2760
Query: 1137 XXXXXXXXXDAFRCDEG-LCIAARFVCDGRPQCADGSDE-APAACAYGHTDQVN 1188
D F C C+ ++CDG C DGSDE + A CA +T N
Sbjct: 2761 CAA------DMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDEN 2808
Score = 47.6 bits (108), Expect = 3e-04
Identities = 31/103 (30%), Positives = 38/103 (36%), Gaps = 15/103 (14%)
Query: 1092 AVSRQCDGQQDCEDGRDEAECGA--------CGGDVRC------ADGTXXXXXXXXXXXX 1137
+ S +C+G+ DC DG DE +C C C DG
Sbjct: 3608 SASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENC 3667
Query: 1138 XXXXXX-XXDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
D F C+ LC +VCDG C D SDEAP C
Sbjct: 3668 ERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMC 3710
Score = 46.8 bits (106), Expect = 5e-04
Identities = 29/91 (31%), Positives = 33/91 (36%), Gaps = 12/91 (13%)
Query: 1096 QCDGQQDCEDGRDEAECG--ACG-GDVRCADGTXXXXX---------XXXXXXXXXXXXX 1143
+CD Q DC D DE C C D CA+G
Sbjct: 3494 RCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNCETSC 3553
Query: 1144 XXDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
D FRC G CI A++ CDG C G DE
Sbjct: 3554 SKDQFRCSNGQCIPAKWKCDGHEDCKYGEDE 3584
Score = 44.8 bits (101), Expect = 0.002
Identities = 36/174 (20%), Positives = 65/174 (37%), Gaps = 4/174 (2%)
Query: 922 GRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXX 981
G I + D + + + +V + Y LYW + SI R +
Sbjct: 2249 GNIQLIKDNWEDRQVIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDR 2308
Query: 982 XXXXXXGLS-RPYHMVLDVLGRTMYWTCADRD--SINATSIDNNSSTGVIVRGDRMLPRH 1038
P+ + LD M+WT + SI +++ ++ V+V D + P
Sbjct: 2309 EAVITMSEDDHPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQ-VVVSTDILTPNG 2367
Query: 1039 LAFHQTKRYLIWNDVGRGAIMRANVDGTGRVELARADNATALALDQSAGTVYWA 1092
L L ++D G I R DG+ R + ++ T L+L ++W+
Sbjct: 2368 LTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWS 2421
Score = 44.8 bits (101), Expect = 0.002
Identities = 47/191 (24%), Positives = 65/191 (34%), Gaps = 11/191 (5%)
Query: 992 PYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWN 1051
P + +D +Y++ I D S VIV+ LA + Y+ W+
Sbjct: 2365 PNGLTIDYRAEKLYFSDGSLGKIERCEYDG-SQRHVIVKSGPGTFLSLAVYDN--YIFWS 2421
Query: 1052 DVGRGAIMRANVDGTGRVELARADNATALALDQSAGTVYWAVSRQCDGQQDCE--DGRDE 1109
D GR AI+R+N G ++ R+D Q G + A C +G
Sbjct: 2422 DWGRRAILRSNKYTGGDTKILRSDIP-----HQPMGIIAVANDTNSCELSPCALLNGGCH 2476
Query: 1110 AECGAC-GGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQC 1168
C G V C+ F C G CI + CDG P C
Sbjct: 2477 DLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAYSEFECGNGECIDYQLTCDGIPHC 2536
Query: 1169 ADGSDEAPAAC 1179
D SDE C
Sbjct: 2537 KDKSDEKLLYC 2547
Score = 41.9 bits (94), Expect = 0.013
Identities = 24/78 (30%), Positives = 30/78 (38%), Gaps = 1/78 (1%)
Query: 1098 DGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCD-EGLCI 1156
D Q C GR AC GD C D + + F+C +G C+
Sbjct: 1008 DNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCV 1067
Query: 1157 AARFVCDGRPQCADGSDE 1174
+ CDG C DGSDE
Sbjct: 1068 PDLWRCDGEKDCEDGSDE 1085
Score = 40.7 bits (91), Expect = 0.031
Identities = 24/77 (31%), Positives = 29/77 (37%), Gaps = 9/77 (11%)
Query: 1103 CEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVC 1162
C+ GR + C D C DG+ + FRC G CI + C
Sbjct: 975 CKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFD---------NQFRCSSGRCIPGHWAC 1025
Query: 1163 DGRPQCADGSDEAPAAC 1179
DG C D SDEA C
Sbjct: 1026 DGDNDCGDFSDEAQINC 1042
Score = 40.3 bits (90), Expect = 0.041
Identities = 36/154 (23%), Positives = 59/154 (38%), Gaps = 11/154 (7%)
Query: 939 TGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLD 998
T + N A+++ + K LYW D + +R+ I L P + LD
Sbjct: 3086 TAVPNALAVDW--IGKNLYWSDTE----KRI-IEVSKLNGLYPTILVSKRLKFPRDLSLD 3138
Query: 999 VLGRTMYWT-CADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGA 1057
+YW C + I +D + + V++ P L R L W D
Sbjct: 3139 PQAGYLYWIDCCEYPHIGRVGMDGTNQS-VVIETKISRPMALTIDYVNRRLYWADENH-- 3195
Query: 1058 IMRANVDGTGRVELARADNATALALDQSAGTVYW 1091
I +N+DG+ R ++ D +AL +YW
Sbjct: 3196 IEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYW 3229
Score = 39.9 bits (89), Expect = 0.054
Identities = 25/82 (30%), Positives = 31/82 (37%), Gaps = 4/82 (4%)
Query: 1095 RQCDGQQ-DCEDGRDEAECG-ACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDE 1152
RQC ++ C DGR C GD C D + F C
Sbjct: 2843 RQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSF--FMCKN 2900
Query: 1153 GLCIAARFVCDGRPQCADGSDE 1174
G CI + +CD + C DGSDE
Sbjct: 2901 GRCIPSGGLCDNKDDCGDGSDE 2922
Score = 39.5 bits (88), Expect = 0.071
Identities = 28/80 (35%), Positives = 33/80 (41%), Gaps = 24/80 (30%)
Query: 1096 QCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRC-DEGL 1154
+CDG++DCEDG DE C G +R D F C G
Sbjct: 1072 RCDGEKDCEDGSDEK---GCNGTIRLCD--------------------HKTKFSCWSTGR 1108
Query: 1155 CIAARFVCDGRPQCADGSDE 1174
CI +VCDG C D SDE
Sbjct: 1109 CINKAWVCDGDIDCEDQSDE 1128
Score = 39.1 bits (87), Expect = 0.094
Identities = 14/27 (51%), Positives = 16/27 (59%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDE 1174
F+C GLC F+CDG C D SDE
Sbjct: 3362 FQCGTGLCALPAFICDGENDCGDNSDE 3388
Score = 37.9 bits (84), Expect = 0.22
Identities = 16/43 (37%), Positives = 21/43 (48%), Gaps = 1/43 (2%)
Query: 1146 DAFRCDEGLCIAARFVCDGRPQCADGSDEAPAACAYGHTDQVN 1188
D F+C CI R++CDG C DE+ C T QV+
Sbjct: 889 DQFKCQNNRCIPKRWLCDGANDCGSNEDESNQTCT-ARTCQVD 930
Score = 36.7 bits (81), Expect = 0.50
Identities = 16/32 (50%), Positives = 19/32 (59%), Gaps = 3/32 (9%)
Query: 1097 CDGQQDCEDGRDEAEC--GACGG-DVRCADGT 1125
CDG+ DC D DE +C C + RCADGT
Sbjct: 2571 CDGENDCGDNSDELDCKVSTCATVEFRCADGT 2602
Score = 36.7 bits (81), Expect = 0.50
Identities = 22/88 (25%), Positives = 30/88 (34%), Gaps = 2/88 (2%)
Query: 1103 CEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAF-RCDE-GLCIAARF 1160
C DG C ++ CAD + F RC+ LC+ +
Sbjct: 2598 CADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTW 2657
Query: 1161 VCDGRPQCADGSDEAPAACAYGHTDQVN 1188
+CDG C D SDE H + N
Sbjct: 2658 ICDGSNDCGDYSDELKCPVQNKHKCEEN 2685
Score = 36.7 bits (81), Expect = 0.50
Identities = 13/27 (48%), Positives = 16/27 (59%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDE 1174
F C G CI ++CDG+ C DG DE
Sbjct: 2687 FSCPSGRCILNTWICDGQKDCEDGRDE 2713
Score = 36.3 bits (80), Expect = 0.66
Identities = 30/103 (29%), Positives = 37/103 (35%), Gaps = 18/103 (17%)
Query: 1096 QCDGQQDCEDGRDE--AEC--GACGGDV------RC------ADGTXXXXXXXXXXXXXX 1139
+CDG DC DG DE C +C D RC DG
Sbjct: 863 KCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESNQTC 922
Query: 1140 XXXX-XXDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAACAY 1181
D F C G CI ++CD C D +DE A+C +
Sbjct: 923 TARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEM-ASCEF 964
Score = 35.9 bits (79), Expect = 0.87
Identities = 28/94 (29%), Positives = 33/94 (35%), Gaps = 15/94 (15%)
Query: 1097 CDGQQDCEDGRDEAECGA--C-GGDVRCADGTXXXXXXXXXXXXXX-----------XXX 1142
CDG+ DC D DE C C G +C
Sbjct: 3376 CDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENS 3435
Query: 1143 XXXDAFRCDEGL-CIAARFVCDGRPQCADGSDEA 1175
D F+C CI+ +VCD P CAD SDEA
Sbjct: 3436 CSPDYFQCKTTKHCISKLWVCDEDPDCADASDEA 3469
Score = 35.5 bits (78), Expect = 1.2
Identities = 13/27 (48%), Positives = 17/27 (62%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDE 1174
F C G CI++++ CD C DGSDE
Sbjct: 973 FVCKSGRCISSKWHCDSDDDCGDGSDE 999
Score = 34.7 bits (76), Expect = 2.0
Identities = 14/33 (42%), Positives = 19/33 (57%), Gaps = 1/33 (3%)
Query: 1148 FRC-DEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F C D C++ ++CDG P C D SDE+ C
Sbjct: 37 FLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTC 69
Score = 34.7 bits (76), Expect = 2.0
Identities = 25/96 (26%), Positives = 36/96 (37%), Gaps = 14/96 (14%)
Query: 1093 VSRQCDGQQDCEDGRDEAEC--GACGGD-VRCADGTXXXXXXXXXXXXXXXXXXXXDA-- 1147
V+ +C+GQ DC D DE +C +C D +C +A
Sbjct: 3412 VNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANC 3471
Query: 1148 ---------FRCDEGLCIAARFVCDGRPQCADGSDE 1174
F+C CI + CD + C+D SDE
Sbjct: 3472 DKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDE 3507
Score = 32.7 bits (71), Expect = 8.1
Identities = 14/32 (43%), Positives = 19/32 (59%), Gaps = 1/32 (3%)
Query: 1146 DAFRCDEGLCIA-ARFVCDGRPQCADGSDEAP 1176
+ F C +G C+ ++ CDG C D SDEAP
Sbjct: 2848 EEFSCADGRCLLNTQWQCDGDFDCPDHSDEAP 2879
>AF283374-1|AAL38108.1| 1731|Homo sapiens candidate tumor suppressor
protein protein.
Length = 1731
Score = 491 bits (1211), Expect = e-138
Identities = 331/1119 (29%), Positives = 542/1119 (48%), Gaps = 68/1119 (6%)
Query: 17 LEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSE-GLVTPTGIAIDWYT 75
L A+DFH+ ++L+ W+D + I +E+ ++V E GL TP G+ +DW
Sbjct: 363 LRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIA 422
Query: 76 DKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDW-GEIPKIER 134
+YW D ++IEV + R L ++ RAIA+ P G++FWTDW P+IE
Sbjct: 423 GNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIES 482
Query: 135 AGMNGDPATRKVIVRD--NIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVK 192
A M+G A RK I +D WPNG+TVD+ I W DA+ + ++G +++
Sbjct: 483 ASMSG--AGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIR 540
Query: 193 GG--LVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESR 250
G L +PFA++ ++YWTDW+ ++ + G + + K+ P D+++Y SR
Sbjct: 541 GHEYLSHPFAVSLYGSEVYWTDWRTNTLSKAN-KWTGQNVSVIQKTSAQPFDLQIYHPSR 599
Query: 251 QIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQ 310
Q + CSH+CL++ + CACP +KL + T CY + LL A+
Sbjct: 600 QPQAPNPCAANDGKGPCSHMCLINHNRSAA-CACPHLMKLSSDKKT-CYGMKKFLLY-AR 656
Query: 311 RSTISKISLDSPDF---TPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGS 367
RS I + +D+P F T +T+P D+ +DFD E +YW D +TI +A ++G+
Sbjct: 657 RSEIRGVDIDNPYFNFITAFTVP--DIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGT 714
Query: 368 D-QSVVVRSSGVPDSIAIDPLSRKIYWTDPVMDT--INVARLDGSYEKVIIHTELYDPRA 424
++V+ R +A+D +SR +YW D INVARLDGS + IIH + P+
Sbjct: 715 GLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSIIHG-IDKPQC 773
Query: 425 IALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDA 484
+A H G ++W+D N I AN+DGS +L + P +++D V NKLYW +
Sbjct: 774 LAAHPVRGKLYWTDGNT----INMANMDGSNSKILFQNQKE-PVGLSIDYVENKLYWISS 828
Query: 485 RTHKIEVCNMDGTERKELHS--NDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQ 542
I CN+DG + + S ++ L +K G +
Sbjct: 829 GNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPT 888
Query: 543 PVVEQMANMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDY-ICGCPLGLELTADKK 601
+ + + ++ +K + A G N C +NGGCS LC + C C +G L ++
Sbjct: 889 ILRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRM 948
Query: 602 TCVEPEAFLVYSRKNIIGRLSIK-NEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTK 660
+C E+FL+YS I + ++ ++ DA++PI + + +YW+D
Sbjct: 949 SCQGIESFLMYSVHEGIRGIPLEPSDKMDALMPISGTSFAVGIDFHAENDTIYWTDMGFN 1008
Query: 661 TINRCSVNGSAVEKIV-EWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIW 719
I+R + + E I+ LG VEG+A+DW NIYWTD IEV+RL+GS R II
Sbjct: 1009 KISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIIS 1068
Query: 720 QGLKKPKSIVLDPKKGYMYWSELGS-KSIKRAAMDGSSVSVFMEQ-VGRVHALAIDYERR 777
QGL +P+SI + P+KG ++W+E G I +A +DGS V + + + ++IDYE
Sbjct: 1069 QGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEEN 1128
Query: 778 AIYWAALDPPVVEFAFLNGTGRQTL---ADNIPMPYALALFNDSVYWGD--WNTGQIQQA 832
+YW +E L G + + N+ M +++A F +YW D G +++
Sbjct: 1129 KLYWCDARTDKIERIDLETGGNREMVLSGSNVDM-FSVAXFGAYIYWSDRAHANGSVRRG 1187
Query: 833 RKTDGSNRKSIRKDLDY-ISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRC 891
K D + ++R L + ++K+++R + G+N C DNGGC LCL RT C
Sbjct: 1188 HKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLYRGNSRRT---C 1244
Query: 892 ACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVAN-GECNDAYIPLTG---LKNVRAI 947
AC AH L +D +TC E +LL++ + + I +++ N P KNV A+
Sbjct: 1245 AC-AHGYLAEDGVTCLRHEGYLLYSGRTILKSIHLSDETNLNSPIRPYENPRYFKNVIAL 1303
Query: 948 EYDPVEK-----QLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGR 1002
+D ++ ++++ D +I+ + ++ GL+ YH D
Sbjct: 1304 AFDYNQRRKGTNRIFYSDAHFGNIQLIKDNWEDRQVIVENVGSVEGLA--YHRAWD---- 1357
Query: 1003 TMYWTCADRDSINATSIDNN-----SSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVG--R 1055
T+YWT + SI ++D VI + P LA + + + W +
Sbjct: 1358 TLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQH 1417
Query: 1056 GAIMRANVDGTGRVELARADNAT--ALALDQSAGTVYWA 1092
+IMR+ + G + D T L +D A +Y++
Sbjct: 1418 PSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFS 1456
Score = 404 bits (994), Expect = e-111
Identities = 250/858 (29%), Positives = 407/858 (47%), Gaps = 42/858 (4%)
Query: 263 NNAGCSHLCLLSPDPPGYNCACPTGVKLR-ENSSTTCYDSPQMLLVVAQRSTISKISLDS 321
N+ CS +C C+C G KL + S T DS + ++ + R I +I L
Sbjct: 296 NHLKCSQVC--EQHKHTVKCSCYEGWKLDVDGESCTSVDSFEAFIIFSIRHEIRRIDLHK 353
Query: 322 PDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSD-----QSVVVRSS 376
D Y+L + L+ T+ +DF +YW D + I + +L S + VV
Sbjct: 354 RD---YSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGL 410
Query: 377 GVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFW 436
P+ + +D ++ IYW D +D I VA+LDGS +I + PRAIAL G +FW
Sbjct: 411 ATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFW 470
Query: 437 SDWNEKKPKIERANLDGSGRVLLISEKLT--WPNSIALDTVNNKLYWGDARTHKIEVCNM 494
+DW+ P+IE A++ G+GR + + T WPN + +D ++ W DAR+ I
Sbjct: 471 TDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALY 530
Query: 495 DGTERKELHSND--IIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMM 552
DGT E+ + H F + TL + NK TG + + + A
Sbjct: 531 DGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPF 590
Query: 553 GVKAFRLG-APLGWNPCA--DDNGGCSHLC-FNRPDDYICGCPLGLELTADKKTCVEPEA 608
++ + P NPCA D G CSH+C N C CP ++L++DKKTC +
Sbjct: 591 DLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACPHLMKLSSDKKTCYGMKK 650
Query: 609 FLVYSRKNIIGRLSIKNEYNDAV--IPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCS 666
FL+Y+R++ I + I N Y + + + D+ +V+ + S +LYW+D KT+TI R
Sbjct: 651 FLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAF 710
Query: 667 VNGSAVEKIVEW-LGLVEGLAIDWSGQNIYW--TDTTTQRIEVSRLDGSSRRAIIWQGLK 723
+NG+ +E ++ + + GLA+DW +N+YW ++ +I V+RLDGS + +II G+
Sbjct: 711 INGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSII-HGID 769
Query: 724 KPKSIVLDPKKGYMYWSELGSKSIKRAAMDGSSVSVFMEQVGRVHALAIDYERRAIYWAA 783
KP+ + P +G +YW++ +I A MDGS+ + + L+IDY +YW +
Sbjct: 770 KPQCLAAHPVRGKLYWTD--GNTINMANMDGSNSKILFQNQKEPVGLSIDYVENKLYWIS 827
Query: 784 LDPPVVEFAFLNGTGR---QTLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNR 840
+ L+G +++ + + AL + + ++W D N Q+ K DG N
Sbjct: 828 SGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNP 887
Query: 841 KSIRKDLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLN 900
+R + +K+Y + GSN C ++NGGCS LCLPT RT C C Y L
Sbjct: 888 TILRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLCLPTSETTRT---CMCTVGYYLQ 944
Query: 901 KDNITCSEPEEFLLFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMD 960
K+ ++C E FL+++ + I + + DA +P++G I++ +YW D
Sbjct: 945 KNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMDALMPISGTSFAVGIDFHAENDTIYWTD 1004
Query: 961 DDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSID 1020
+ I R GL R + +D + +YWT + I +
Sbjct: 1005 MGFNKISR-----AKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARL- 1058
Query: 1021 NNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGR-GAIMRANVDGTGRVELARADNA-- 1077
N S VI+ PR +A H K L W + G+ I +A +DG+ +V L A
Sbjct: 1059 NGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWP 1118
Query: 1078 TALALDQSAGTVYWAVSR 1095
+++D +YW +R
Sbjct: 1119 NGISIDYEENKLYWCDAR 1136
Score = 355 bits (874), Expect = 4e-97
Identities = 268/961 (27%), Positives = 450/961 (46%), Gaps = 58/961 (6%)
Query: 16 DLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAIDWYT 75
D++ T +DF + + W+D K + I+ N T G + ++S + + G+A+DW +
Sbjct: 680 DIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGT--GLE-TVISRDIQSIRGLAVDWVS 736
Query: 76 DKLYWTDGETNKIEV-ISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIER 134
LYW E ++ ++ ++ + K +D + +A P G ++WTD I
Sbjct: 737 RNLYWISSEFDETQINVARLDGSLKTSIIHGIDKPQCLAAHPVRGKLYWTDGNTI---NM 793
Query: 135 AGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRV--VK 192
A M+G + I+ N P G+++DY + +YW+ + ++ + +G + + +K
Sbjct: 794 ANMDG---SNSKILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMK 850
Query: 193 GGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESRQI 252
L ALT + KL+W D QN + +G L +KVYD+ Q
Sbjct: 851 EELTKATALTIMDKKLWWAD-QNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQ 909
Query: 253 ISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRS 312
S C+ NN GCS LCL + + C C G L++N + C + L+ +
Sbjct: 910 GSNS---CQLNNGGCSQLCLPTSETTR-TCMCTVGYYLQKNRMS-C-QGIESFLMYSVHE 963
Query: 313 TISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGS-DQSV 371
I I L+ D +P+ + +DF + + IYW D IS+A+ D + + +
Sbjct: 964 GIRGIPLEPSDKMDALMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDI 1023
Query: 372 VVRSSGVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTA 431
+ G + IA+D ++ IYWTD + I VARL+GS+ VII L PR+IA+H
Sbjct: 1024 ITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEK 1083
Query: 432 GWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEV 491
G +FW++W + P I +A LDGS +V+L+S + WPN I++D NKLYW DART KIE
Sbjct: 1084 GLLFWTEWGQM-PCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIER 1142
Query: 492 CNMD-GTERKELHSNDIIHIFGXXXXXXXX--XXXXMQKRTLDRINKNTGLDRQPVVEQM 548
+++ G R+ + S + +F ++ R +KN + + +
Sbjct: 1143 IDLETGGNREMVLSGSNVDMFSVAXFGAYIYWSDRAHANGSVRRGHKNDATETITMRTGL 1202
Query: 549 A-NMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDY-ICGCPLGLELTADKKTCVEP 606
N+ VK F G N CA DNGGC LC R + C C G L D TC+
Sbjct: 1203 GVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLYRGNSRRTCACAHGY-LAEDGVTCLRH 1261
Query: 607 EAFLVYSRKNIIGRLSIKNE--YNDAVIPIKD---LKEVSALALYVSG-----SKLYWSD 656
E +L+YS + I+ + + +E N + P ++ K V ALA + +++++SD
Sbjct: 1262 EGYLLYSGRTILKSIHLSDETNLNSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSD 1321
Query: 657 SKTKTINRCSVNGSAVEKIVEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGS---- 712
+ I N + IVE +G VEGLA + +YWT +TT I +D +
Sbjct: 1322 AHFGNIQLIKDNWEDRQVIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGA 1381
Query: 713 -SRRAIIWQGLKK-PKSIVLDPKKGYMYWSELGSK--SIKRAAMDGSSVSVFME-QVGRV 767
R A+I P + LD + M+W+ + SI R+ + G + V + +
Sbjct: 1382 FDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTP 1441
Query: 768 HALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPMPY-ALALFNDSVYWGDWNT 826
+ L IDY +Y++ +E +G+ R + + P + +LA++++ ++W DW
Sbjct: 1442 NGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGR 1501
Query: 827 GQIQQARKTDGSNRKSIRKDLDY--ISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGD 884
I ++ K G + K +R D+ + + + + + S + C + NGGC LCL TP
Sbjct: 1502 RAILRSNKYTGGDTKILRSDIPHQPMGIIAVANDTNSCELSPCALLNGGCHDLCLLTPNG 1561
Query: 885 VRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVANGECNDAYIPLTGLKNV 944
C+C L +DN ++ + NA NGEC D + G+ +
Sbjct: 1562 ---RVNCSCRGDRILLEDNRCVTKN------SSCNAYSEFECGNGECIDYQLTCDGIPHC 1612
Query: 945 R 945
+
Sbjct: 1613 K 1613
Score = 81.4 bits (192), Expect = 2e-14
Identities = 74/255 (29%), Positives = 119/255 (46%), Gaps = 19/255 (7%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKL-RENSSTTCYDSPQMLLVVAQRSTISKIS 318
C NN GCS+ C + P G C+CP G++L ++N + D L +Q K +
Sbjct: 252 CSLNNGGCSNHCSVVPG-RGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHT 310
Query: 319 LDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGV 378
+ + + L D+ D +I ++ + I + L D S++V G+
Sbjct: 311 VKCSCYEGWKL---DVDGESCTSVDSFEAFIIFS--IRHEIRRIDLHKRDYSLLV--PGL 363
Query: 379 PDSIAIDPLSRK--IYWTDPVMDTINVARLDG----SYEKVIIHTELYDPRAIALHLTAG 432
++IA+D + +YWTD V D I +L S +V++ L P + + AG
Sbjct: 364 RNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAG 423
Query: 433 WMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYW--GDARTHKIE 490
++W D N +IE A LDGS R LI+ + P +IALD L+W DA +IE
Sbjct: 424 NIYWIDSN--LDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIE 481
Query: 491 VCNMDGTERKELHSN 505
+M G RK ++ +
Sbjct: 482 SASMSGAGRKTIYKD 496
Score = 76.6 bits (180), Expect = 5e-13
Identities = 73/297 (24%), Positives = 126/297 (42%), Gaps = 15/297 (5%)
Query: 568 CADDNGGCSHLCFNRPD-DYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGRLSIKNE 626
C+ +NGGCS+ C P +C CP GL+L D KTC + + + + + K+
Sbjct: 252 CSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCE-QHKHT 310
Query: 627 YNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVEGLA 686
+ L V + + S I R ++ +V L L
Sbjct: 311 VKCSCYEGWKLDVDGESCTSVDSFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALD 370
Query: 687 IDWSGQNIYWTDTTTQRI---EVSRLDG-SSRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
++ +YWTD RI ++S G S+ ++ GL P+ + +D G +YW +
Sbjct: 371 FHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDS 430
Query: 743 GSKSIKRAAMDGS-SVSVFMEQVGRVHALAIDYERRAIYWAALDP--PVVEFAFLNGTGR 799
I+ A +DGS ++ + A+A+D ++W D P +E A ++G GR
Sbjct: 431 NLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGR 490
Query: 800 QTLADNI---PMPYALAL--FNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYIS 851
+T+ ++ P L + F + W D + I A DG+N I + +Y+S
Sbjct: 491 KTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSA-LYDGTNMIEIIRGHEYLS 546
Score = 62.5 bits (145), Expect = 9e-09
Identities = 43/146 (29%), Positives = 68/146 (46%), Gaps = 8/146 (5%)
Query: 9 RITTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTG 68
R I++ L+Q ++ H K L+ W++ + C+ EK +VS G+ P G
Sbjct: 1063 RYVIISQGLDQPRSIAVHPEKGLLFWTEWGQ--MPCIGKARLDGSEKVVLVSMGIAWPNG 1120
Query: 69 IAIDWYTDKLYWTDGETNKIEVISIVQ--KYRKVLFWSEVDLARAIAVVPEDGLMFWTDW 126
I+ID+ +KLYW D T+KIE I + VL S VD+ +V ++W+D
Sbjct: 1121 ISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDM---FSVAXFGAYIYWSDR 1177
Query: 127 GEIPKIERAGMNGDPATRKVIVRDNI 152
R G D AT + +R +
Sbjct: 1178 AHANGSVRRGHKND-ATETITMRTGL 1202
Score = 49.6 bits (113), Expect = 7e-05
Identities = 53/232 (22%), Positives = 85/232 (36%), Gaps = 16/232 (6%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRI 924
++C ++NGGCS+ C PG C+CP +LNKDN TC + + + V
Sbjct: 250 DECSLNNGGCSNHCSVVPG---RGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQ 306
Query: 925 MVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXX 984
+C+ + D E + + H IRR+ +
Sbjct: 307 HKHTVKCSCYEGWKLDVDGESCTSVDSFEAFIIF--SIRHEIRRIDLHKRDYSLLVPGLR 364
Query: 985 XXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNN---SSTGVIVRGDRMLPRHLAF 1041
L ++ L +YWT D I + + S+ V+V P L
Sbjct: 365 NTIALDFHFNQSL------LYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTV 418
Query: 1042 HQTKRYLIWNDVGRGAIMRANVDGTGRVEL--ARADNATALALDQSAGTVYW 1091
+ W D I A +DG+ R L ++ A+ALD G ++W
Sbjct: 419 DWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFW 470
Score = 44.8 bits (101), Expect = 0.002
Identities = 36/174 (20%), Positives = 65/174 (37%), Gaps = 4/174 (2%)
Query: 922 GRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXX 981
G I + D + + + +V + Y LYW + SI R +
Sbjct: 1325 GNIQLIKDNWEDRQVIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDR 1384
Query: 982 XXXXXXGLS-RPYHMVLDVLGRTMYWTCADRD--SINATSIDNNSSTGVIVRGDRMLPRH 1038
P+ + LD M+WT + SI +++ ++ V+V D + P
Sbjct: 1385 EAVITMSEDDHPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQ-VVVSTDILTPNG 1443
Query: 1039 LAFHQTKRYLIWNDVGRGAIMRANVDGTGRVELARADNATALALDQSAGTVYWA 1092
L L ++D G I R DG+ R + ++ T L+L ++W+
Sbjct: 1444 LTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWS 1497
Score = 44.8 bits (101), Expect = 0.002
Identities = 47/191 (24%), Positives = 65/191 (34%), Gaps = 11/191 (5%)
Query: 992 PYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWN 1051
P + +D +Y++ I D S VIV+ LA + Y+ W+
Sbjct: 1441 PNGLTIDYRAEKLYFSDGSLGKIERCEYDG-SQRHVIVKSGPGTFLSLAVYDN--YIFWS 1497
Query: 1052 DVGRGAIMRANVDGTGRVELARADNATALALDQSAGTVYWAVSRQCDGQQDCE--DGRDE 1109
D GR AI+R+N G ++ R+D Q G + A C +G
Sbjct: 1498 DWGRRAILRSNKYTGGDTKILRSDIP-----HQPMGIIAVANDTNSCELSPCALLNGGCH 1552
Query: 1110 AECGAC-GGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQC 1168
C G V C+ F C G CI + CDG P C
Sbjct: 1553 DLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAYSEFECGNGECIDYQLTCDGIPHC 1612
Query: 1169 ADGSDEAPAAC 1179
D SDE C
Sbjct: 1613 KDKSDEKLLYC 1623
Score = 41.9 bits (94), Expect = 0.013
Identities = 24/78 (30%), Positives = 30/78 (38%), Gaps = 1/78 (1%)
Query: 1098 DGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCD-EGLCI 1156
D Q C GR AC GD C D + + F+C +G C+
Sbjct: 84 DNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCV 143
Query: 1157 AARFVCDGRPQCADGSDE 1174
+ CDG C DGSDE
Sbjct: 144 PDLWRCDGEKDCEDGSDE 161
Score = 40.7 bits (91), Expect = 0.031
Identities = 24/77 (31%), Positives = 29/77 (37%), Gaps = 9/77 (11%)
Query: 1103 CEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVC 1162
C+ GR + C D C DG+ + FRC G CI + C
Sbjct: 51 CKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFD---------NQFRCSSGRCIPGHWAC 101
Query: 1163 DGRPQCADGSDEAPAAC 1179
DG C D SDEA C
Sbjct: 102 DGDNDCGDFSDEAQINC 118
Score = 39.5 bits (88), Expect = 0.071
Identities = 28/80 (35%), Positives = 33/80 (41%), Gaps = 24/80 (30%)
Query: 1096 QCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRC-DEGL 1154
+CDG++DCEDG DE C G +R D F C G
Sbjct: 148 RCDGEKDCEDGSDEK---GCNGTIRLCD--------------------HKTKFSCWSTGR 184
Query: 1155 CIAARFVCDGRPQCADGSDE 1174
CI +VCDG C D SDE
Sbjct: 185 CINKAWVCDGDIDCEDQSDE 204
Score = 36.7 bits (81), Expect = 0.50
Identities = 16/32 (50%), Positives = 19/32 (59%), Gaps = 3/32 (9%)
Query: 1097 CDGQQDCEDGRDEAEC--GACGG-DVRCADGT 1125
CDG+ DC D DE +C C + RCADGT
Sbjct: 1647 CDGENDCGDNSDELDCKVSTCATVEFRCADGT 1678
Score = 35.5 bits (78), Expect = 1.2
Identities = 13/27 (48%), Positives = 17/27 (62%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDE 1174
F C G CI++++ CD C DGSDE
Sbjct: 49 FVCKSGRCISSKWHCDSDDDCGDGSDE 75
Score = 34.3 bits (75), Expect = 2.7
Identities = 14/36 (38%), Positives = 19/36 (52%), Gaps = 1/36 (2%)
Query: 1146 DAFRCDEGLCIAARFVCDGRPQCADGSDEAPAACAY 1181
D F C G CI ++CD C D +DE A+C +
Sbjct: 6 DQFSCGNGRCIPRAWLCDREDDCGDQTDEM-ASCEF 40
>X13916-1|CAA32112.1| 4544|Homo sapiens LDL-receptor related precursor
(AA -19 to 4525) protein.
Length = 4544
Score = 484 bits (1193), Expect = e-136
Identities = 334/1148 (29%), Positives = 569/1148 (49%), Gaps = 81/1148 (7%)
Query: 11 TTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSE-GLVTPTGI 69
+ + L A+DFH ++ + W+D + I + F++V + GL TP G+
Sbjct: 1290 SVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGL 1349
Query: 70 AIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDW-GE 128
A+DW +YW + ++IEV + R L +++ RAIA+ P DG++FWTDW
Sbjct: 1350 AVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDAS 1409
Query: 129 IPKIERAGMNGDPATRKVIVRD--NIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEK 186
+P+IE A M+G A R+ + R+ + WPNG+TVDY I W+DA+ + ++G
Sbjct: 1410 LPRIEAASMSG--AGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSG 1467
Query: 187 RKRVVKGG--LVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIK 244
V++G L +PFA+T ++YWTDW+ ++ + G + + +++ P D++
Sbjct: 1468 HMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKAN-KWTGHNVTVVQRTNTQPFDLQ 1526
Query: 245 VYDESRQIISAEDYPCKKN--NAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSP 302
VY SRQ ++ PC+ N CSHLCL++ + +CACP +KL ++ +TTCY+
Sbjct: 1527 VYHPSRQPMAPN--PCEANGGQGPCSHLCLINYNRT-VSCACPHLMKLHKD-NTTCYEFK 1582
Query: 303 QMLLVVAQRSTISKISLDSPDFT---PYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTI 359
+ LL A++ I + LD+P + +T+P D+ +D+D + + +YW+D + I
Sbjct: 1583 KFLL-YARQMEIRGVDLDAPYYNYIISFTVP--DIDNVTVLDYDAREQRVYWSDVRTQAI 1639
Query: 360 SKARLDGSDQSVVVRSSGVPDS--IAIDPLSRKIYWT--DPVMDTINVARLDGSYEKVII 415
+A ++G+ VV S+ +P++ +A+D +SR ++WT D INVARLDGS++ ++
Sbjct: 1640 KRAFINGTGVETVV-SADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV 1698
Query: 416 HTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTV 475
L P + +H G ++W+D + I AN+DGS R LL S + P +A+D
Sbjct: 1699 Q-GLEQPHGLVVHPLRGKLYWTDGD----NISMANMDGSNRTLLFSGQ-KGPVGLAIDFP 1752
Query: 476 NNKLYWGDARTHKIEVCNMDGT--ERKELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRI 533
+KLYW + H I CN+DG+ E + + + +
Sbjct: 1753 ESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTC 1812
Query: 534 NKNTGLDRQPVVEQMANMMGVKAFRLGAPL---GWNPCADDNGGCSHLCFNRPD-DYICG 589
+K G + +M +K + L G NPC+ +NG CS LC + C
Sbjct: 1813 SKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSCM 1872
Query: 590 CPLGLELTADKKTCVEPEAFLVYS-RKNIIGRLSIKNEYNDAVIPIKDLKEVSALALYVS 648
C G L + ++ C +FL+YS + I G N+ +DA++P+ + +
Sbjct: 1873 CTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAE 1932
Query: 649 GSKLYWSDSKTKTINRCSVNGSAVEKIV-EWLGLVEGLAIDWSGQNIYWTDTTTQRIEVS 707
+YW D TI+R + + E +V +G VEG+A+DW NIYWTD IEV+
Sbjct: 1933 NDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVA 1992
Query: 708 RLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGS-KSIKRAAMDGSSVSVFME-QVG 765
RL+GS R +I QGL KP++I + P+KGY++W+E G I+R+ +DG+ V + +
Sbjct: 1993 RLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSIS 2052
Query: 766 RVHALAIDYERRAIYWAALDPPVVEFAFL-NGTGRQ-TLADNIPMPYALALFNDSVYWGD 823
+ +++DY+ +YW +E L G R+ L+ N +++++F D +YW D
Sbjct: 2053 WPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSD 2112
Query: 824 WN--TGQIQQARKTDGSNRKSIRKDLD-YISDLKLYHRAKSMGSNQCGVDNGGCSHLCLP 880
G I++ K + ++ +R + + D+K+++R + G+N C V NGGC LCL
Sbjct: 2113 RTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLY 2172
Query: 881 TPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVANGECNDAYI-PLT 939
R CAC AH L +D +C E +LL++++ + I +++ +A + P
Sbjct: 2173 RG---RGQRACAC-AHGMLAEDGASCREYAGYLLYSERTILKSIHLSDERNLNAPVQPFE 2228
Query: 940 G---LKNVRAIEYD-------PVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGL 989
+KNV A+ +D ++++ D +I+++ GL
Sbjct: 2229 DPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIVENVGSVEGL 2288
Query: 990 SRPYHMVLDVLGRTMYWTCADRDSINATSIDN------NSSTGVIVRGDRMLPRHLAFHQ 1043
+ YH D T+YWT +I ++D T + + GD PR +
Sbjct: 2289 A--YHRGWD----TLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDH-PRAFVLDE 2341
Query: 1044 TKRYLIWNDVG--RGAIMRANVDGTGRVELARADNAT--ALALDQSAGTVYWAVSRQCDG 1099
+ + W + +IMRA + G + L D T LA+D A +Y++ D
Sbjct: 2342 CQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFS-DATLDK 2400
Query: 1100 QQDCE-DG 1106
+ CE DG
Sbjct: 2401 IERCEYDG 2408
Score = 397 bits (977), Expect = e-109
Identities = 288/970 (29%), Positives = 470/970 (48%), Gaps = 59/970 (6%)
Query: 10 ITTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGI 69
I+ D++ T +D+ R+ + WSD + + I+ N T G + +VS L G+
Sbjct: 1607 ISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGT--GVE-TVVSADLPNAHGL 1663
Query: 70 AIDWYTDKLYWTDGETNK--IEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWG 127
A+DW + L+WT +TNK I V + ++ + ++ + V P G ++WTD G
Sbjct: 1664 AVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVVQG-LEQPHGLVVHPLRGKLYWTD-G 1721
Query: 128 EIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKR 187
+ I A M+G + + ++ P G+ +D+ S +YW+ + ++ + +G
Sbjct: 1722 D--NISMANMDG---SNRTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGL 1776
Query: 188 KRV--VKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKV 245
+ + ++ L AL DKL+W D + + T A+G L S + +KV
Sbjct: 1777 EVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCS-KADGSGSVVLRNSTTLVMHMKV 1835
Query: 246 YDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQML 305
YDES Q+ PC NN CS LCL + + +C C G LR C L
Sbjct: 1836 YDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTR-SCMCTAGYSLRSGQQA-CEGVGSFL 1893
Query: 306 LVVAQRSTISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLD 365
L I I LD D + +P+ + +DF + + IYW D TIS+A+ D
Sbjct: 1894 LYSVHEG-IRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRD 1952
Query: 366 GS-DQSVVVRSSGVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRA 424
+ + VV G + IA+D ++ IYWTD D I VARL+GS+ V+I L PRA
Sbjct: 1953 QTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRA 2012
Query: 425 IALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDA 484
I +H G++FW++W + P+IER+ LDG+ RV+L++ ++WPN I++D + KLYW DA
Sbjct: 2013 ITVHPEKGYLFWTEWGQY-PRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDA 2071
Query: 485 RTHKIEVCNMDGTERKE--LHSNDI-IHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDR 541
RT KIE +++ E +E L SN++ + ++ R +K+ D
Sbjct: 2072 RTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDS 2131
Query: 542 QPVVEQMA-NMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRP-DDYICGCPLGLELTAD 599
P+ + + +K F G N CA NGGC LC R C C G+ L D
Sbjct: 2132 VPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGRGQRACACAHGM-LAED 2190
Query: 600 KKTCVEPEAFLVYSRKNIIGRLSIKNE--YNDAVIPIKD---LKEVSALAL-YVSGS--- 650
+C E +L+YS + I+ + + +E N V P +D +K V ALA Y +G+
Sbjct: 2191 GASCREYAGYLLYSERTILKSIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPG 2250
Query: 651 ---KLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVS 707
++++SD I + + +GS IVE +G VEGLA +YWT TT I
Sbjct: 2251 TPNRIFFSDIHFGNIQQINDDGSRRITIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRH 2310
Query: 708 RLD----GSSRR--AIIWQGLKKPKSIVLDPKKGYMYWSELGSK--SIKRAAMDGSSVSV 759
+D G+ R I G P++ VLD + M+W+ + SI RAA+ G++V
Sbjct: 2311 TVDQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLT 2370
Query: 760 FMEQVGRV-HALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPM-PYALALFND 817
+E+ R + LAID+ +Y++ +E +G+ R + + P+ P+ LA++ +
Sbjct: 2371 LIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGE 2430
Query: 818 SVYWGDWNTGQIQQARKTDGSNRKSIRKDLDY--ISDLKLYHRAKSMGSNQCGVDNGGCS 875
++W DW +Q+A K GSN K +R D+ + + + + S + C ++NGGC
Sbjct: 2431 HIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQ 2490
Query: 876 HLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVANGECNDAY 935
LCL T + C+C R+ +D++TC + + A ANGEC +
Sbjct: 2491 DLCLLTH---QGHVNCSCRGG-RILQDDLTCR-----AVNSSCRAQDEFECANGECINFS 2541
Query: 936 IPLTGLKNVR 945
+ G+ + +
Sbjct: 2542 LTCDGVPHCK 2551
Score = 377 bits (927), Expect = e-103
Identities = 252/876 (28%), Positives = 418/876 (47%), Gaps = 50/876 (5%)
Query: 253 ISAEDYPCKKNNAGCSHL-CLLSPDPPGYN--CACPTGVKLR-ENSSTTCYDSPQMLLVV 308
+ +++ C+ + HL C D ++ C+C G L + S D + ++
Sbjct: 1214 LGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFIIF 1273
Query: 309 AQRSTISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARL--DG 366
+ R I +I L D Y++ + L+ T+ +DF +YW D + I + +L +G
Sbjct: 1274 SNRHEIRRIDLHKGD---YSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNG 1330
Query: 367 ---SDQSVVVRSSGVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPR 423
S + V+ P+ +A+D ++ IYW + +D I VA+LDG+ ++ ++ PR
Sbjct: 1331 ALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPR 1390
Query: 424 AIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLT--WPNSIALDTVNNKLYW 481
AIAL G +FW+DW+ P+IE A++ G+GR + E + WPN + +D + ++ W
Sbjct: 1391 AIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEKRILW 1450
Query: 482 GDARTHKIEVCNMDGTERKE-LHSNDII-HIFGXXXXXXXXXXXXMQKRTLDRINKNTGL 539
DAR+ I DG+ E L ++ + H F + TL + NK TG
Sbjct: 1451 IDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGH 1510
Query: 540 DRQPVVEQMANMMGVKAFRLG-APLGWNPCADDNGG---CSHLC-FNRPDDYICGCPLGL 594
+ V ++ + P+ NPC + NGG CSHLC N C CP +
Sbjct: 1511 NVTVVQRTNTQPFDLQVYHPSRQPMAPNPC-EANGGQGPCSHLCLINYNRTVSCACPHLM 1569
Query: 595 ELTADKKTCVEPEAFLVYSRKNIIGRLSIKNEYNDAVI--PIKDLKEVSALALYVSGSKL 652
+L D TC E + FL+Y+R+ I + + Y + +I + D+ V+ L ++
Sbjct: 1570 KLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVLDYDAREQRV 1629
Query: 653 YWSDSKTKTINRCSVNGSAVEKIVEW-LGLVEGLAIDWSGQNIYWT--DTTTQRIEVSRL 709
YWSD +T+ I R +NG+ VE +V L GLA+DW +N++WT DT ++I V+RL
Sbjct: 1630 YWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARL 1689
Query: 710 DGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKSIKRAAMDGSS-VSVFMEQVGRVH 768
DGS + A++ QGL++P +V+ P +G +YW++ +I A MDGS+ +F Q G V
Sbjct: 1690 DGSFKNAVV-QGLEQPHGLVVHPLRGKLYWTD--GDNISMANMDGSNRTLLFSGQKGPV- 1745
Query: 769 ALAIDYERRAIYWAALDPPVVEFAFLNGTGRQ---TLADNIPMPYALALFNDSVYWGDWN 825
LAID+ +YW + + L+G+G + + + ALA+ D ++W D
Sbjct: 1746 GLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKLWWADQV 1805
Query: 826 TGQIQQARKTDGSNRKSIRKDLDYISDLKLYHRAKSM---GSNQCGVDNGGCSHLCLPTP 882
+ ++ K DGS +R + +K+Y + + G+N C V+NG CS LCLPT
Sbjct: 1806 SEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQLCLPTS 1865
Query: 883 GDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVANGECNDAYIPLTGLK 942
R+ C C A Y L C FLL++ + I + + +DA +P++G
Sbjct: 1866 ETTRS---CMCTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSGTS 1922
Query: 943 NVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGR 1002
I++ +YW+D +I R G+ R + +D +
Sbjct: 1923 LAVGIDFHAENDTIYWVDMGLSTISR-----AKRDQTWREDVVTNGIGRVEGIAVDWIAG 1977
Query: 1003 TMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGR-GAIMRA 1061
+YWT D I + N S V++ PR + H K YL W + G+ I R+
Sbjct: 1978 NIYWTDQGFDVIEVARL-NGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERS 2036
Query: 1062 NVDGTGRVELARADNA--TALALDQSAGTVYWAVSR 1095
+DGT RV L + +++D G +YW +R
Sbjct: 2037 RLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDAR 2072
Score = 260 bits (637), Expect = 2e-68
Identities = 201/717 (28%), Positives = 342/717 (47%), Gaps = 62/717 (8%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLR-ENSSTTCYDSP---QMLLVVAQRSTISKISLDSP 322
CS LC + + C C G L+ +N S + P +L++A I L
Sbjct: 160 CSQLCTNTDG--SFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGA 217
Query: 323 DFTPYTLPLKDLKRTLTVDFDPKTEYIYWA---DGLAKTISK-ARLDGS----DQSVVVR 374
+ T+ ++T +DF E + W D A+T K AR+ G D+ +
Sbjct: 218 QVS--TITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINI 275
Query: 375 SSGVP--DSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAG 432
S + + +AID L+ Y+ D + D I V +G ++ ELY+P+ IAL G
Sbjct: 276 SLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMG 335
Query: 433 WMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVC 492
+F++D+ + PK+ER ++DG R L+ K+ +P+ I LD V+ +YW DA IEV
Sbjct: 336 KVFFTDYGQI-PKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVV 394
Query: 493 NMDGTERKELHSNDII-HIFGXX------XXXXXXXXXXMQKRTLDRINKNTGLDRQPVV 545
+ +G R+ + +I H++G QK ++ R+N+ + Q V
Sbjct: 395 DYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVT 454
Query: 546 E-QMANMMGVKAFRLGAPLGWNPCADDN----GGCSHLCF--NRPDDYICGCPLGLELTA 598
+ + R + + C +D GGCS +C N C C G L +
Sbjct: 455 RVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGS 514
Query: 599 DKKTCVEP--EAFLVY--SRKNIIGRLSIKNEYNDA-VIPIKDLKEVSALALYVSGSKLY 653
D K+C +P E FLVY R II + + + D +IPI++L AL + +Y
Sbjct: 515 DGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIY 574
Query: 654 WSDSKTKTINRCSVNGSAVEKIV-EWLGLVEGLAIDWSGQNIYWTDTTTQR-IEVSRLD- 710
++D+ + I R ++G+ E I+ + + VEG+A+DW G N+YWTD ++ I V+RL+
Sbjct: 575 FADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEK 634
Query: 711 -GSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSK-------SIKRAAMDGSSVSVFM- 761
+R+ +I + P++IV+DP G+MYW++ ++RA MDGS +F+
Sbjct: 635 AAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVT 694
Query: 762 -EQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPMPYALAL--FNDS 818
+ V + L++D +YW +E LNGT R+ + + + +A L +
Sbjct: 695 SKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGNY 754
Query: 819 VYWGDWNTGQIQQARKTDGSNRKSI---RKDLDYISDLKLYH-RAKSMGSNQCGVDNGGC 874
++W ++ +G + + + G ++ R + I ++++Y + + +G+N+C V+NGGC
Sbjct: 755 LFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGGC 814
Query: 875 SHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVANGEC 931
S LCL TPG +CAC L+ D +TC ++ Q G AN C
Sbjct: 815 SSLCLATPG----SRQCACAEDQVLDADGVTCLANPSYVPPPQCQP-GEFACANSRC 866
Score = 255 bits (625), Expect = 6e-67
Identities = 176/636 (27%), Positives = 312/636 (49%), Gaps = 38/636 (5%)
Query: 9 RITTIAK-DLEQGTAVDFHYRKNLICW---SDQKPEL-IQC--MNYNETYTGEKFKIVSE 61
+++TI Q TA+DF Y +CW D + ++C M + + E +S
Sbjct: 218 QVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISL 277
Query: 62 GLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLM 121
L +AIDW T Y+ D ++I V + L E+ + IA+ P G +
Sbjct: 278 SLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKV 337
Query: 122 FWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVID 181
F+TD+G+IPK+ER M+G T+ +V I +P+GIT+D + L+YW DA L +++V+D
Sbjct: 338 FFTDYGQIPKVERCDMDGQNRTK--LVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVD 395
Query: 182 FNGEKRKRVVKGGLV-YPFALTFSNDKLYWTDWQNWSIY--TWDIAANGPKIKE--LIKS 236
+ G+ R+ +++G L+ + + LT + LY T+ N + T I N E ++
Sbjct: 396 YEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVTR 455
Query: 237 HPVPADIKVYDESRQIISAEDYPCKKNN----AGCSHLCLLSPDPPGYNCACPTGVKLRE 292
+ +Y + RQ + C+ + GCS +CLL+ C C +G L
Sbjct: 456 VDKGGALHIYHQRRQ-PRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGS 514
Query: 293 NSSTTCYDSPQMLLVV--AQRSTISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIY 350
+ + ++ LV + I + + + + +P+++L +DF +T +IY
Sbjct: 515 DGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIY 574
Query: 351 WADGLAKTISKARLDGSDQSVVVRSSGV--PDSIAIDPLSRKIYWTDP-VMDTINVARLD 407
+AD + I + ++DG+++ +++ G+ + +A+D + +YWTD TI+VARL+
Sbjct: 575 FADTTSYLIGRQKIDGTERETILK-DGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLE 633
Query: 408 GSYE--KVIIHTELYDPRAIALHLTAGWMFWSDWNE-----KKPKIERANLDGSGRVLLI 460
+ + K +I ++ PRAI + GWM+W+DW E ++ ++ERA +DGS R + +
Sbjct: 634 KAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFV 693
Query: 461 SEK-LTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSN-DIIHIFGXXXXXX 518
+ K + WPN ++LD +LYW DA +IE ++GT+RK ++ ++ H FG
Sbjct: 694 TSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGN 753
Query: 519 XXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFRL----GAPLGWNPCADDNGG 574
+ ++ R+ + G V + + R+ +G N C +NGG
Sbjct: 754 YLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGG 813
Query: 575 CSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFL 610
CS LC P C C L AD TC+ +++
Sbjct: 814 CSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYV 849
Score = 219 bits (534), Expect = 6e-56
Identities = 125/345 (36%), Positives = 191/345 (55%), Gaps = 19/345 (5%)
Query: 575 CSHLCFNRPDDYICGCPLGLELTA-DKKTC---VEPEAFLVYSRKNIIGRLSIKNEYNDA 630
CS C N Y C C G D +C + E FL+++ + + +L++ N
Sbjct: 2992 CSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGS-NYT 3050
Query: 631 VIPIKDLKEVSALALYVSGSKLYWSDSKTK--TINRCSVNGSAVEKIVEWLGLV--EGLA 686
++ + L AL +YW+D T+ I R +NGS V+ ++ GL +GLA
Sbjct: 3051 LLK-QGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQ-VLHRTGLSNPDGLA 3108
Query: 687 IDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS 746
+DW G N+YW D IEVS+L+G+ R ++ GL++P+++V+D + GY+YW++ G S
Sbjct: 3109 VDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHS 3168
Query: 747 -IKRAAMDGSSVSVFME-QVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQ-TLA 803
I R MDGSS SV ++ ++ + L +DY IYWA +EFA L+G+ R L+
Sbjct: 3169 LIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLS 3228
Query: 804 DNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYH--RAKS 861
+IP +AL LF D VYW DW T I +A KT G+N+ + L DL ++H R
Sbjct: 3229 QDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPD 3288
Query: 862 MGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
+ ++ C V+NGGCS+LCL +PG ++CACP ++ L D TC
Sbjct: 3289 VPNHPCKVNNGGCSNLCLLSPGG---GHKCACPTNFYLGSDGRTC 3330
Score = 206 bits (503), Expect = 4e-52
Identities = 111/346 (32%), Positives = 182/346 (52%), Gaps = 14/346 (4%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLRENSSTTC--YDSPQMLLVVAQRSTISKISLDSPDF 324
CS C+ + Y C C G R +C + L+ A R + K++LD +
Sbjct: 2992 CSQRCINTHG--SYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSN- 3048
Query: 325 TPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAK--TISKARLDGSDQSVVVRSS-GVPDS 381
YTL + L + +DFD + + IYW D + I + L+GS+ V+ R+ PD
Sbjct: 3049 --YTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDG 3106
Query: 382 IAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNE 441
+A+D + +YW D DTI V++L+G+Y V++ + L +PRA+ + + G+++W+DW +
Sbjct: 3107 LAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGD 3166
Query: 442 KKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKE 501
I R +DGS R +++ K+TWPN + LD V ++YW DAR IE ++DG+ R
Sbjct: 3167 HS-LIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHV 3225
Query: 502 LHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFR-LG 560
+ S DI HIF + ++++R +K TG ++ ++ + M + F L
Sbjct: 3226 VLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALR 3285
Query: 561 AP-LGWNPCADDNGGCSHLCFNRP-DDYICGCPLGLELTADKKTCV 604
P + +PC +NGGCS+LC P + C CP L +D +TCV
Sbjct: 3286 QPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCV 3331
Score = 197 bits (481), Expect = 2e-49
Identities = 109/289 (37%), Positives = 156/289 (53%), Gaps = 12/289 (4%)
Query: 11 TTIAKDLEQGTAVDFHYRKNLICWSDQKPE--LIQCMNYNETYTGEKFKIVSE-GLVTPT 67
T + + L A+DF YR+ +I W+D + +I+ M+ N G +++ GL P
Sbjct: 3050 TLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLN----GSNVQVLHRTGLSNPD 3105
Query: 68 GIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWG 127
G+A+DW LYW D + IEV + YR VL S + RA+ V ++G ++WTDWG
Sbjct: 3106 GLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWG 3165
Query: 128 EIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKR 187
+ I R GM+G ++R VIV I WPNG+T+DY IYW DA+ +++ +G R
Sbjct: 3166 DHSLIGRIGMDG--SSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNR 3223
Query: 188 KRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYD 247
V+ + + FALT D +YWTDW+ SI G LI + P D+ V+
Sbjct: 3224 HVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAH-KTTGTNKTLLISTLHRPMDLHVFH 3282
Query: 248 ESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSST 296
RQ ++PCK NN GCS+LCLLSP G+ CACPT L + T
Sbjct: 3283 ALRQ-PDVPNHPCKVNNGGCSNLCLLSPG-GGHKCACPTNFYLGSDGRT 3329
Score = 153 bits (370), Expect = 5e-36
Identities = 89/243 (36%), Positives = 122/243 (50%), Gaps = 12/243 (4%)
Query: 62 GLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLM 121
GL P GIAIDW +YWTD + IEV + + RK L +D AI V P G M
Sbjct: 3956 GLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTM 4015
Query: 122 FWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVID 181
+W+DWG PKIE A M+G R+ +V+DNI WP G+ VDY+N +YW DAKL + I
Sbjct: 4016 YWSDWGNHPKIETAAMDG--TLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIR 4073
Query: 182 FNGEKRKRVV--KGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPV 239
NG K GL +PF++ D +Y + N ++ + P + L
Sbjct: 4074 LNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLV-NLTGGLSH 4132
Query: 240 PADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCY 299
+D+ +Y + +Q PC + C LCLLSP P C CP G +L +N +
Sbjct: 4133 ASDVVLYHQHKQ--PEVTNPCDRKK--CEWLCLLSPSGP--VCTCPNGKRL-DNGTCVPV 4185
Query: 300 DSP 302
SP
Sbjct: 4186 PSP 4188
Score = 148 bits (358), Expect = 1e-34
Identities = 142/568 (25%), Positives = 238/568 (41%), Gaps = 59/568 (10%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTCV-------EPEAFLVYSRKNIIGRLSIKN 625
G CS LC N +ICGC G L D ++C P L+ + +NI+ +
Sbjct: 158 GTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATY-LSG 216
Query: 626 EYNDAVIPIKDLKEVSALALYVSGSKLYW---SDSKTKTINRCS----VNGSAVEKIVE- 677
+ P ++ +A+ + + W DS +T +C+ + G E +
Sbjct: 217 AQVSTITP-TSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINI 275
Query: 678 --WLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKG 735
L VE +AIDW N Y+ D RI V +G + ++ L PK I LDP G
Sbjct: 276 SLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMG 335
Query: 736 YMYWSELGS-KSIKRAAMDGSSVSVFME-QVGRVHALAIDYERRAIYWAALDPPVVEFAF 793
+++++ G ++R MDG + + ++ ++ H + +D R +YWA +E
Sbjct: 336 KVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVD 395
Query: 794 LNGTGRQTLADNIPMP--YALALFNDSVYWGDWNTGQIQQARKTDGSNR-----KSIRKD 846
G GRQT+ I + Y L +F + +Y + + QQ NR +
Sbjct: 396 YEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVTR 455
Query: 847 LDYISDLKLYH--RAKSMGSNQCGVDN----GGCSHLC-LPTPGDVRTDYRCACPAHYRL 899
+D L +YH R + S+ C D GGCS +C L RT C C + + L
Sbjct: 456 VDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKART---CRCRSGFSL 512
Query: 900 NKDNITCSEPEE--FLLFAQ-KNAVGRIMVANGECNDAY-IPLTGLKNVRAIEYDPVEKQ 955
D +C +PE FL++ + + + R M + D + IP+ L N RA+++
Sbjct: 513 GSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGF 572
Query: 956 LYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWT-CADRDSI 1014
+Y+ D S+ I R I G+ + +D +G +YWT + +I
Sbjct: 573 IYFADTTSYLIGRQKID-----GTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTI 627
Query: 1015 NATSIDNNSST-GVIVRGDRMLPRHLAFHQTKRYLIW-------NDVGRGAIMRANVDGT 1066
+ ++ + T ++ G PR + ++ W D RG + RA +DG+
Sbjct: 628 SVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGS 687
Query: 1067 GRVELARADNA---TALALDQSAGTVYW 1091
R + L+LD AG +YW
Sbjct: 688 HRDIFVTSKTVLWPNGLSLDIPAGRLYW 715
Score = 135 bits (326), Expect = 1e-30
Identities = 102/360 (28%), Positives = 169/360 (46%), Gaps = 35/360 (9%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVY-SRKNIIGRLSIKNEYN--D 629
G CS LC N ++C C T + E ++Y + N I L + ++ +
Sbjct: 3832 GTCSQLCNNTKGGHLCSCARNFMKTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYE 3891
Query: 630 AVIPIKDLKEVSALALYVSGSKLYWSDSKTKTIN----------------RCSVNGSAVE 673
+ + A+ ++V ++YW++ T TI+ R ++
Sbjct: 3892 QAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTH 3951
Query: 674 KIVEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPK 733
+ L + G+AIDW N+YWTD+ IEV+++ G +R+ +I + +P +IV+DP
Sbjct: 3952 LNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPL 4011
Query: 734 KGYMYWSELGS-KSIKRAAMDGS-SVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEF 791
+G MYWS+ G+ I+ AAMDG+ ++ + + LA+DY +YWA V+
Sbjct: 4012 RGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGS 4071
Query: 792 AFLNGTGRQTLADN---IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLD 848
LNGT AD+ + P+++ +F D +Y + ++ + K S ++ L
Sbjct: 4072 IRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLS 4131
Query: 849 YISDLKLYHRAKSMG-SNQCGVDNGGCSHLCLPTP-GDVRTDYRCACPAHYRLNKDNITC 906
+ SD+ LYH+ K +N C D C LCL +P G V C CP RL DN TC
Sbjct: 4132 HASDVVLYHQHKQPEVTNPC--DRKKCEWLCLLSPSGPV-----CTCPNGKRL--DNGTC 4182
Score = 111 bits (268), Expect = 1e-23
Identities = 96/359 (26%), Positives = 151/359 (42%), Gaps = 30/359 (8%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDSPDFTP 326
CS LC + G+ C+C ++ +++ S +L +A + I + P +
Sbjct: 3834 CSQLC--NNTKGGHLCSCARNF-MKTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPH-SA 3889
Query: 327 YTLPLK--DLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGS-------------DQSV 371
Y + + R +D K +YW + TIS L + D+ V
Sbjct: 3890 YEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGV 3949
Query: 372 V-VRSSGV--PDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALH 428
+ SG+ P IAID ++ +YWTD D I VA++ G K +I + +P AI +
Sbjct: 3950 THLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVD 4009
Query: 429 LTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHK 488
G M+WSDW PKIE A +DG+ R L+ + + WP +A+D N +LYW DA+
Sbjct: 4010 PLRGTMYWSDWG-NHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSV 4068
Query: 489 IEVCNMDGTER--KELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVE 546
I ++GT+ + H F + +I+K +
Sbjct: 4069 IGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTG 4128
Query: 547 QMANMMGVKAF-RLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
+++ V + + P NPC D C LC P +C CP G L D TCV
Sbjct: 4129 GLSHASDVVLYHQHKQPEVTNPC--DRKKCEWLCLLSPSGPVCTCPNGKRL--DNGTCV 4183
Score = 93.9 bits (223), Expect = 3e-18
Identities = 81/254 (31%), Positives = 130/254 (51%), Gaps = 21/254 (8%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDS-PQMLLVVAQRSTISKIS 318
C NN GCSH C ++P G C+CP G++L ++ T S L +Q+ +K S
Sbjct: 1185 CSLNNGGCSHNCSVAPG-EGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFS 1243
Query: 319 LDSPDFTPYTL-PLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSG 377
+ + + L P + R+L DP +I +++ I + L D SV+V G
Sbjct: 1244 VKCSCYEGWVLEPDGESCRSL----DPFKPFIIFSN--RHEIRRIDLHKGDYSVLV--PG 1295
Query: 378 VPDSIAID-PLSRK-IYWTDPVMDTINVARL--DGSYE--KVIIHTELYDPRAIALHLTA 431
+ ++IA+D LS+ +YWTD V D I +L +G+ +V+I L P +A+ A
Sbjct: 1296 LRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIA 1355
Query: 432 GWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYW--GDARTHKI 489
G ++W + N +IE A LDG+ R L++ + P +IALD + L+W DA +I
Sbjct: 1356 GNIYWVESN--LDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRI 1413
Query: 490 EVCNMDGTERKELH 503
E +M G R+ +H
Sbjct: 1414 EAASMSGAGRRTVH 1427
Score = 87.0 bits (206), Expect = 4e-16
Identities = 79/302 (26%), Positives = 135/302 (44%), Gaps = 25/302 (8%)
Query: 568 CADDNGGCSHLCFNRPDD-YICGCPLGLELTADKKTC-VEP--EAFLVYSRKNIIGRLSI 623
C+ +NGGCSH C P + +C CPLG+EL D TC ++ L S+K + S+
Sbjct: 1185 CSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSV 1244
Query: 624 KNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVE 683
K + + D + +L + K + S I R ++ +V GL
Sbjct: 1245 KCSCYEGWVLEPDGESCRSLDPF----KPFIIFSNRHEIRRIDLHKGDYSVLVP--GLRN 1298
Query: 684 GLAIDW--SGQNIYWTDTTTQRIEVSRL--DG--SSRRAIIWQGLKKPKSIVLDPKKGYM 737
+A+D+ S +YWTD +I +L +G +S +I GL P+ + +D G +
Sbjct: 1299 TIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNI 1358
Query: 738 YWSELGSKSIKRAAMDGS-SVSVFMEQVGRVHALAIDYERRAIYWAALDP--PVVEFAFL 794
YW E I+ A +DG+ ++ + A+A+D ++W D P +E A +
Sbjct: 1359 YWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASM 1418
Query: 795 NGTGRQTL-----ADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDY 849
+G GR+T+ + P + + W D + I AR DGS + + ++
Sbjct: 1419 SGAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSAR-YDGSGHMEVLRGHEF 1477
Query: 850 IS 851
+S
Sbjct: 1478 LS 1479
Score = 75.4 bits (177), Expect = 1e-12
Identities = 63/232 (27%), Positives = 102/232 (43%), Gaps = 22/232 (9%)
Query: 874 CSHLCLPTPGDVRTDYRCACPAHYR-LNKDNITC---SEPEEFLLFAQKNAVGRIMVANG 929
CS C+ T G Y+C C Y D +C ++ E FL+FA + + ++ N
Sbjct: 2992 CSQRCINTHGS----YKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKL---NL 3044
Query: 930 ECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHS--IRRVPISYXXXXXXXXXXXXXX 987
+ ++ + GL N A+++D E+ +YW D + IRR+ ++
Sbjct: 3045 DGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLN-----GSNVQVLHRT 3099
Query: 988 GLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRY 1047
GLS P + +D +G +YW RD+I + + N + V+V PR L Y
Sbjct: 3100 GLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKL-NGAYRTVLVSSGLREPRALVVDVQNGY 3158
Query: 1048 LIWNDVG-RGAIMRANVDGTGRVEL--ARADNATALALDQSAGTVYWAVSRQ 1096
L W D G I R +DG+ R + + L LD +YWA +R+
Sbjct: 3159 LYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADARE 3210
Score = 65.3 bits (152), Expect = 1e-09
Identities = 62/235 (26%), Positives = 97/235 (41%), Gaps = 22/235 (9%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC---SEPEEFLLFAQKNAV 921
+QC ++NGGCSH C PG+ C+CP L DN TC S + L +QK
Sbjct: 1183 DQCSLNNGGCSHNCSVAPGE---GIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQ 1239
Query: 922 GRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXX 981
+ V C + ++ ++ R++ DP + + + + H IRR+ +
Sbjct: 1240 NKFSV-KCSCYEGWVLEPDGESCRSL--DPFKPFIIF--SNRHEIRRIDLHKGDYSVLVP 1294
Query: 982 XXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSI-NATSIDNNSSTG--VIVRGDRMLPRH 1038
L +H+ L YWT D I +DN + T V+++ P
Sbjct: 1295 GLRNTIALD--FHLSQSAL----YWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEG 1348
Query: 1039 LAFHQTKRYLIWNDVGRGAIMRANVDGTGRVELARAD--NATALALDQSAGTVYW 1091
LA + W + I A +DGT R L D + A+ALD G ++W
Sbjct: 1349 LAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFW 1403
Score = 64.9 bits (151), Expect = 2e-09
Identities = 48/186 (25%), Positives = 82/186 (44%), Gaps = 11/186 (5%)
Query: 35 SDQKPELIQCMNY---NETYTGEKFKIVSEGLVTPTGIAIDWYTDKLYWTDGET--NKIE 89
+D++P LI Y G + ++ +GL + D+ +YWTD T + I
Sbjct: 3025 TDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIR 3084
Query: 90 VISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERAGMNGDPATRKVIVR 149
+ + +VL + + +AV G ++W D G IE + +NG A R V+V
Sbjct: 3085 RMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGR-DTIEVSKLNG--AYRTVLVS 3141
Query: 150 DNIFWPNGITVDYNNSLIYWVD-AKLQFVDVIDFNGEKRKRVVKGGLVYPFALT--FSND 206
+ P + VD N +YW D + I +G R +V + +P LT + +
Sbjct: 3142 SGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTE 3201
Query: 207 KLYWTD 212
++YW D
Sbjct: 3202 RIYWAD 3207
Score = 56.4 bits (130), Expect = 6e-07
Identities = 60/252 (23%), Positives = 92/252 (36%), Gaps = 18/252 (7%)
Query: 933 DAYIPLTGLKNVRAIEYDPVEKQLYWMD-DDSH-SIRRVPISYXXXXXXXXXXXXXXGLS 990
+ I ++G + RA D + ++W + ++ H SI R +S +
Sbjct: 2323 ETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALS-----GANVLTLIEKDIR 2377
Query: 991 RPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIW 1050
P + +D +Y++ A D I D S VI++ + + P LA + ++ W
Sbjct: 2378 TPNGLAIDHRAEKLYFSDATLDKIERCEYDG-SHRYVILKSEPVHPFGLAVYG--EHIFW 2434
Query: 1051 NDVGRGAIMRANVDGTGRVELARADNATALALDQSAGTVYWAVSRQCDGQQDCE--DGRD 1108
D R A+ RAN ++L R D Q G + A C +G
Sbjct: 2435 TDWVRRAVQRANKHVGSNMKLLRVDIP-----QQPMGIIAVANDTNSCELSPCRINNGGC 2489
Query: 1109 EAECGACG-GDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQ 1167
+ C G V C+ D F C G CI CDG P
Sbjct: 2490 QDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFECANGECINFSLTCDGVPH 2549
Query: 1168 CADGSDEAPAAC 1179
C D SDE P+ C
Sbjct: 2550 CKDKSDEKPSYC 2561
Score = 52.0 bits (119), Expect = 1e-05
Identities = 49/170 (28%), Positives = 60/170 (35%), Gaps = 8/170 (4%)
Query: 923 RIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXX 982
R M NG N + TGL N + D V LYW D R I
Sbjct: 3084 RRMHLNGS-NVQVLHRTGLSNPDGLAVDWVGGNLYWCDKG-----RDTIEVSKLNGAYRT 3137
Query: 983 XXXXXGLSRPYHMVLDVLGRTMYWT-CADRDSINATSIDNNSSTGVIVRGDRMLPRHLAF 1041
GL P +V+DV +YWT D I +D SS VIV P L
Sbjct: 3138 VLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDG-SSRSVIVDTKITWPNGLTL 3196
Query: 1042 HQTKRYLIWNDVGRGAIMRANVDGTGRVELARADNATALALDQSAGTVYW 1091
+ W D I A++DG+ R + D AL VYW
Sbjct: 3197 DYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYW 3246
Score = 51.6 bits (118), Expect = 2e-05
Identities = 63/253 (24%), Positives = 89/253 (35%), Gaps = 22/253 (8%)
Query: 945 RAIEYDPVEKQLYWMD--DDSHSIRRVPISYX-XXXXXXXXXXXXXGLSRPYHMVLDVLG 1001
RAI DP+ +YW D +D RR + + P + LD+
Sbjct: 651 RAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPA 710
Query: 1002 RTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGAIMRA 1061
+YW A D I T + N + ++ G + H YL W + G++ R
Sbjct: 711 GRLYWVDAFYDRIE-TILLNGTDRKIVYEGPELNHAFGLCHHGN-YLFWTEYRSGSVYRL 768
Query: 1062 N--VDGTG-RVELARADNATALALDQSAGTVYWAVSRQCDGQQDCE--DGRDEAECGACG 1116
V G V L R++ + +Y A +Q G C +G + C A
Sbjct: 769 ERGVGGAPPTVTLLRSERPPIFEI-----RMYDAQQQQV-GTNKCRVNNGGCSSLCLATP 822
Query: 1117 GDVRCADGTXXXXXXXXXXXXXXXXXX-----XXDAFRCDEGLCIAARFVCDGRPQCADG 1171
G +CA F C CI R+ CDG C D
Sbjct: 823 GSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDN 882
Query: 1172 SDEAPAACAYGHT 1184
SDEAPA C + HT
Sbjct: 883 SDEAPALC-HQHT 894
Score = 50.8 bits (116), Expect = 3e-05
Identities = 33/100 (33%), Positives = 38/100 (38%), Gaps = 16/100 (16%)
Query: 1096 QCDGQQDCEDGRDEAECGA---------CGGDVRC------ADGTXXXXXXXXXXXXXXX 1140
+C+GQ +C DG DE +C C RC D
Sbjct: 3432 RCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQ 3491
Query: 1141 XXXXXDAFRC-DEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
D FRC D G CI AR+ CDG C DGSDE C
Sbjct: 3492 MTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEEC 3531
Score = 48.4 bits (110), Expect = 2e-04
Identities = 39/114 (34%), Positives = 42/114 (36%), Gaps = 30/114 (26%)
Query: 1093 VSRQ--CDGQQDCEDGRDEAE------CGA-----------------CGGDVRCADGTXX 1127
+S+Q CDG DC DG DEA CG C GD CADG
Sbjct: 2747 ISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADE 2806
Query: 1128 XXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAACAY 1181
F C CI FVCD CADGSDE+P C Y
Sbjct: 2807 SIAAGCLYNSTCDDRE----FMCQNRQCIPKHFVCDHDRDCADGSDESP-ECEY 2855
Score = 48.0 bits (109), Expect = 2e-04
Identities = 28/83 (33%), Positives = 32/83 (38%), Gaps = 2/83 (2%)
Query: 1094 SRQCDGQQ-DCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCD- 1151
S C Q C GR E C GD C D + D F+C
Sbjct: 1012 SHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRL 1071
Query: 1152 EGLCIAARFVCDGRPQCADGSDE 1174
+GLCI R+ CDG C D SDE
Sbjct: 1072 DGLCIPLRWRCDGDTDCMDSSDE 1094
Score = 48.0 bits (109), Expect = 2e-04
Identities = 30/99 (30%), Positives = 35/99 (35%), Gaps = 14/99 (14%)
Query: 1096 QCDGQQDCEDGRDEAECGA-CGGDV-------------RCADGTXXXXXXXXXXXXXXXX 1141
+CDG DC DG DE +C C D RC
Sbjct: 3593 KCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVR 3652
Query: 1142 XXXXDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAACA 1180
D F+C+ LC + CDG C D SDE P CA
Sbjct: 3653 TCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECA 3691
Score = 47.2 bits (107), Expect = 4e-04
Identities = 32/107 (29%), Positives = 43/107 (40%), Gaps = 15/107 (14%)
Query: 1093 VSRQCDGQQDCEDGRDEAECGACGGDV-------RC------ADGTXXXXXXXXXXXXXX 1139
+S CD + DCE G DE C + RC DG+
Sbjct: 2711 MSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCE 2770
Query: 1140 XXXXXXDAFRCD-EGLCIAARFVCDGRPQCADGSDEAPAA-CAYGHT 1184
+F C +C+ R++CDG CADG+DE+ AA C Y T
Sbjct: 2771 GKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNST 2817
Score = 43.6 bits (98), Expect = 0.004
Identities = 32/95 (33%), Positives = 36/95 (37%), Gaps = 17/95 (17%)
Query: 1096 QCDGQQDCEDGRDEA--ECGA---------CGGDVRCADGTXXXXXXXXXXXXXXXXXXX 1144
+CDG+ DC DG DE EC C + RC G
Sbjct: 3513 KCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNN-RCVPGRWQCDYDNDCGDNSDEESCT 3571
Query: 1145 -----XDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
F C G CIA R+ CDG CADGSDE
Sbjct: 3572 PRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDE 3606
Score = 43.2 bits (97), Expect = 0.006
Identities = 25/86 (29%), Positives = 35/86 (40%), Gaps = 7/86 (8%)
Query: 1096 QCD-GQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGL 1154
QC G+ C + R E C GD C D + D F+C+
Sbjct: 853 QCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPS------DRFKCENNR 906
Query: 1155 CIAARFVCDGRPQCADGSDEAPAACA 1180
CI R++CDG C + DE+ A C+
Sbjct: 907 CIPNRWLCDGDNDCGNSEDESNATCS 932
Score = 41.9 bits (94), Expect = 0.013
Identities = 18/44 (40%), Positives = 21/44 (47%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAACAYGHTDQVNGIH 1191
F+C+ G CI + CDG C D SDE A C T G H
Sbjct: 1020 FKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCH 1063
Score = 40.7 bits (91), Expect = 0.031
Identities = 33/101 (32%), Positives = 37/101 (36%), Gaps = 23/101 (22%)
Query: 1097 CDGQQDCEDGRDEAECG--ACG-GDVRCADGTXXXXXX---------XXXXXXXXXXXXX 1144
C+G DC DG DE C ACG G+ RC DGT
Sbjct: 2585 CNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDC 2644
Query: 1145 XDAFR----------CDE-GLCIAARFVCDGRPQCADGSDE 1174
FR C+ LC A +VCDG C D SDE
Sbjct: 2645 SSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDE 2685
Score = 39.5 bits (88), Expect = 0.071
Identities = 26/119 (21%), Positives = 47/119 (39%), Gaps = 1/119 (0%)
Query: 9 RITTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGL-VTPT 67
R T +A D+E A+ R ++ W+D L + + + G + G P
Sbjct: 1378 RTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPN 1437
Query: 68 GIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDW 126
G+ +D+ ++ W D ++ I + L+ AV G ++WTDW
Sbjct: 1438 GLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDW 1496
Score = 39.1 bits (87), Expect = 0.094
Identities = 17/33 (51%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 1148 FRC-DEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F C D+ CI+ + CDG C DGSDEAP C
Sbjct: 32 FACRDQITCISKGWRCDGERDCPDGSDEAPEIC 64
Score = 38.7 bits (86), Expect = 0.12
Identities = 29/100 (29%), Positives = 38/100 (38%), Gaps = 22/100 (22%)
Query: 1097 CDGQQDCEDGRDEA-ECG--ACG-GDVRCADGTXXXXXXXXXXXXXXXXXXXXDA----- 1147
CD +DC DG DE+ EC CG + RCA+G +A
Sbjct: 2837 CDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPH 2896
Query: 1148 -------------FRCDEGLCIAARFVCDGRPQCADGSDE 1174
F C G C+A +C+G+ C D SDE
Sbjct: 2897 CTSPEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDE 2936
Score = 38.7 bits (86), Expect = 0.12
Identities = 14/28 (50%), Positives = 17/28 (60%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEA 1175
F+C G+C F+CDG C D SDEA
Sbjct: 3379 FQCSTGICTNPAFICDGDNDCQDNSDEA 3406
Score = 38.3 bits (85), Expect = 0.16
Identities = 33/139 (23%), Positives = 53/139 (38%), Gaps = 7/139 (5%)
Query: 935 YIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYH 994
++ ++GLK R I D V +YW D R I + P+
Sbjct: 3951 HLNISGLKMPRGIAIDWVAGNVYWTDSG-----RDVIEVAQMKGENRKTLISGMIDEPHA 4005
Query: 995 MVLDVLGRTMYWT-CADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDV 1053
+V+D L TMYW+ + I ++D + +V+ + P LA L W D
Sbjct: 4006 IVVDPLRGTMYWSDWGNHPKIETAAMD-GTLRETLVQDNIQWPTGLAVDYHNERLYWADA 4064
Query: 1054 GRGAIMRANVDGTGRVELA 1072
I ++GT + A
Sbjct: 4065 KLSVIGSIRLNGTDPIVAA 4083
Score = 37.9 bits (84), Expect = 0.22
Identities = 16/30 (53%), Positives = 20/30 (66%), Gaps = 1/30 (3%)
Query: 1148 FRCDEGLCIAAR-FVCDGRPQCADGSDEAP 1176
FRC G C+++R + CDG C D SDEAP
Sbjct: 2863 FRCANGRCLSSRQWECDGENDCHDQSDEAP 2892
Score = 36.7 bits (81), Expect = 0.50
Identities = 25/82 (30%), Positives = 29/82 (35%), Gaps = 6/82 (7%)
Query: 1107 RDEAEC--GACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFR-CDEGLCIAARFVCD 1163
+DE EC G C DG FR C G C++ C+
Sbjct: 2527 QDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCN 2586
Query: 1164 GRPQCADGSDEAP---AACAYG 1182
G C DGSDE P AC G
Sbjct: 2587 GADDCGDGSDEIPCNKTACGVG 2608
Score = 35.9 bits (79), Expect = 0.87
Identities = 12/36 (33%), Positives = 24/36 (66%)
Query: 58 IVSEGLVTPTGIAIDWYTDKLYWTDGETNKIEVISI 93
+V + + PTG+A+D++ ++LYW D + + I I +
Sbjct: 4039 LVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRL 4074
Score = 35.5 bits (78), Expect = 1.2
Identities = 16/34 (47%), Positives = 19/34 (55%), Gaps = 1/34 (2%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAACAY 1181
F C G CI + CD C D SDE+ A+CAY
Sbjct: 941 FSCASGRCIPISWTCDLDDDCGDRSDES-ASCAY 973
Score = 35.1 bits (77), Expect = 1.5
Identities = 19/60 (31%), Positives = 27/60 (45%), Gaps = 2/60 (3%)
Query: 1035 LPRHLAFHQTKRYLIWNDVGRGAIMRANVDGTGRVELARA--DNATALALDQSAGTVYWA 1092
+PR +A + W D GR I A + G R L D A+ +D GT+YW+
Sbjct: 3959 MPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWS 4018
Score = 34.7 bits (76), Expect = 2.0
Identities = 32/113 (28%), Positives = 36/113 (31%), Gaps = 20/113 (17%)
Query: 1097 CDGQQDCEDGRDE-AECG--ACGGD-VRCADGTXXXXXXXXXXXXXXXXXXXXDA----- 1147
CD DC DG DE A C CG D RC D +
Sbjct: 3473 CDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECD 3532
Query: 1148 --------FRCDEGLCIAARFVCDGRPQCADGSDE---APAACAYGHTDQVNG 1189
FRC C+ R+ CD C D SDE P C+ NG
Sbjct: 3533 ERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANG 3585
Score = 33.5 bits (73), Expect = 4.7
Identities = 11/20 (55%), Positives = 14/20 (70%)
Query: 1093 VSRQCDGQQDCEDGRDEAEC 1112
+ RQCDG +C DG DE +C
Sbjct: 3712 IGRQCDGTDNCGDGTDEEDC 3731
Score = 33.1 bits (72), Expect = 6.2
Identities = 13/28 (46%), Positives = 15/28 (53%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEA 1175
F C+ G CI + CD C D SDEA
Sbjct: 982 FTCNNGRCININWRCDNDNDCGDNSDEA 1009
Score = 33.1 bits (72), Expect = 6.2
Identities = 33/173 (19%), Positives = 60/173 (34%), Gaps = 4/173 (2%)
Query: 922 GRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXX-XXXXX 980
G I N + + + + +V + Y LYW + +I R +
Sbjct: 2263 GNIQQINDDGSRRITIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFER 2322
Query: 981 XXXXXXXGLSRPYHMVLDVLGRTMYWTCADRD--SINATSIDNNSSTGVIVRGDRMLPRH 1038
G P VLD M+WT + SI ++ + ++ ++ D P
Sbjct: 2323 ETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAAL-SGANVLTLIEKDIRTPNG 2381
Query: 1039 LAFHQTKRYLIWNDVGRGAIMRANVDGTGRVELARADNATALALDQSAGTVYW 1091
LA L ++D I R DG+ R + +++ L ++W
Sbjct: 2382 LAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFW 2434
>DQ314873-1|ABC40732.1| 4544|Homo sapiens low density
lipoprotein-related protein 1 (alpha-2-macroglobulin
receptor) protein.
Length = 4544
Score = 484 bits (1193), Expect = e-136
Identities = 334/1148 (29%), Positives = 569/1148 (49%), Gaps = 81/1148 (7%)
Query: 11 TTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSE-GLVTPTGI 69
+ + L A+DFH ++ + W+D + I + F++V + GL TP G+
Sbjct: 1290 SVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGL 1349
Query: 70 AIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDW-GE 128
A+DW +YW + ++IEV + R L +++ RAIA+ P DG++FWTDW
Sbjct: 1350 AVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDAS 1409
Query: 129 IPKIERAGMNGDPATRKVIVRD--NIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEK 186
+P+IE A M+G A R+ + R+ + WPNG+TVDY I W+DA+ + ++G
Sbjct: 1410 LPRIEAASMSG--AGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSG 1467
Query: 187 RKRVVKGG--LVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIK 244
V++G L +PFA+T ++YWTDW+ ++ + G + + +++ P D++
Sbjct: 1468 HMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKAN-KWTGHNVTVVQRTNTQPFDLQ 1526
Query: 245 VYDESRQIISAEDYPCKKN--NAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSP 302
VY SRQ ++ PC+ N CSHLCL++ + +CACP +KL ++ +TTCY+
Sbjct: 1527 VYHPSRQPMAPN--PCEANGGQGPCSHLCLINYNRT-VSCACPHLMKLHKD-NTTCYEFK 1582
Query: 303 QMLLVVAQRSTISKISLDSPDFT---PYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTI 359
+ LL A++ I + LD+P + +T+P D+ +D+D + + +YW+D + I
Sbjct: 1583 KFLL-YARQMEIRGVDLDAPYYNYIISFTVP--DIDNVTVLDYDAREQRVYWSDVRTQAI 1639
Query: 360 SKARLDGSDQSVVVRSSGVPDS--IAIDPLSRKIYWT--DPVMDTINVARLDGSYEKVII 415
+A ++G+ VV S+ +P++ +A+D +SR ++WT D INVARLDGS++ ++
Sbjct: 1640 KRAFINGTGVETVV-SADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV 1698
Query: 416 HTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTV 475
L P + +H G ++W+D + I AN+DGS R LL S + P +A+D
Sbjct: 1699 Q-GLEQPHGLVVHPLRGKLYWTDGD----NISMANMDGSNRTLLFSGQ-KGPVGLAIDFP 1752
Query: 476 NNKLYWGDARTHKIEVCNMDGT--ERKELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRI 533
+KLYW + H I CN+DG+ E + + + +
Sbjct: 1753 ESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTC 1812
Query: 534 NKNTGLDRQPVVEQMANMMGVKAFRLGAPL---GWNPCADDNGGCSHLCFNRPD-DYICG 589
+K G + +M +K + L G NPC+ +NG CS LC + C
Sbjct: 1813 SKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSCM 1872
Query: 590 CPLGLELTADKKTCVEPEAFLVYS-RKNIIGRLSIKNEYNDAVIPIKDLKEVSALALYVS 648
C G L + ++ C +FL+YS + I G N+ +DA++P+ + +
Sbjct: 1873 CTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAE 1932
Query: 649 GSKLYWSDSKTKTINRCSVNGSAVEKIV-EWLGLVEGLAIDWSGQNIYWTDTTTQRIEVS 707
+YW D TI+R + + E +V +G VEG+A+DW NIYWTD IEV+
Sbjct: 1933 NDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVA 1992
Query: 708 RLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGS-KSIKRAAMDGSSVSVFME-QVG 765
RL+GS R +I QGL KP++I + P+KGY++W+E G I+R+ +DG+ V + +
Sbjct: 1993 RLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSIS 2052
Query: 766 RVHALAIDYERRAIYWAALDPPVVEFAFL-NGTGRQ-TLADNIPMPYALALFNDSVYWGD 823
+ +++DY+ +YW +E L G R+ L+ N +++++F D +YW D
Sbjct: 2053 WPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSD 2112
Query: 824 WN--TGQIQQARKTDGSNRKSIRKDLD-YISDLKLYHRAKSMGSNQCGVDNGGCSHLCLP 880
G I++ K + ++ +R + + D+K+++R + G+N C V NGGC LCL
Sbjct: 2113 RTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLY 2172
Query: 881 TPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVANGECNDAYI-PLT 939
R CAC AH L +D +C E +LL++++ + I +++ +A + P
Sbjct: 2173 RG---RGQRACAC-AHGMLAEDGASCREYAGYLLYSERTILKSIHLSDERNLNAPVQPFE 2228
Query: 940 G---LKNVRAIEYD-------PVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGL 989
+KNV A+ +D ++++ D +I+++ GL
Sbjct: 2229 DPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIVENVGSVEGL 2288
Query: 990 SRPYHMVLDVLGRTMYWTCADRDSINATSIDN------NSSTGVIVRGDRMLPRHLAFHQ 1043
+ YH D T+YWT +I ++D T + + GD PR +
Sbjct: 2289 A--YHRGWD----TLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDH-PRAFVLDE 2341
Query: 1044 TKRYLIWNDVG--RGAIMRANVDGTGRVELARADNAT--ALALDQSAGTVYWAVSRQCDG 1099
+ + W + +IMRA + G + L D T LA+D A +Y++ D
Sbjct: 2342 CQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFS-DATLDK 2400
Query: 1100 QQDCE-DG 1106
+ CE DG
Sbjct: 2401 IERCEYDG 2408
Score = 397 bits (977), Expect = e-109
Identities = 288/970 (29%), Positives = 470/970 (48%), Gaps = 59/970 (6%)
Query: 10 ITTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGI 69
I+ D++ T +D+ R+ + WSD + + I+ N T G + +VS L G+
Sbjct: 1607 ISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGT--GVE-TVVSADLPNAHGL 1663
Query: 70 AIDWYTDKLYWTDGETNK--IEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWG 127
A+DW + L+WT +TNK I V + ++ + ++ + V P G ++WTD G
Sbjct: 1664 AVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVVQG-LEQPHGLVVHPLRGKLYWTD-G 1721
Query: 128 EIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKR 187
+ I A M+G + + ++ P G+ +D+ S +YW+ + ++ + +G
Sbjct: 1722 D--NISMANMDG---SNRTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGL 1776
Query: 188 KRV--VKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKV 245
+ + ++ L AL DKL+W D + + T A+G L S + +KV
Sbjct: 1777 EVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCS-KADGSGSVVLRNSTTLVMHMKV 1835
Query: 246 YDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQML 305
YDES Q+ PC NN CS LCL + + +C C G LR C L
Sbjct: 1836 YDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTR-SCMCTAGYSLRSGQQA-CEGVGSFL 1893
Query: 306 LVVAQRSTISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLD 365
L I I LD D + +P+ + +DF + + IYW D TIS+A+ D
Sbjct: 1894 LYSVHEG-IRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRD 1952
Query: 366 GS-DQSVVVRSSGVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRA 424
+ + VV G + IA+D ++ IYWTD D I VARL+GS+ V+I L PRA
Sbjct: 1953 QTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRA 2012
Query: 425 IALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDA 484
I +H G++FW++W + P+IER+ LDG+ RV+L++ ++WPN I++D + KLYW DA
Sbjct: 2013 ITVHPEKGYLFWTEWGQY-PRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDA 2071
Query: 485 RTHKIEVCNMDGTERKE--LHSNDI-IHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDR 541
RT KIE +++ E +E L SN++ + ++ R +K+ D
Sbjct: 2072 RTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDS 2131
Query: 542 QPVVEQMA-NMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRP-DDYICGCPLGLELTAD 599
P+ + + +K F G N CA NGGC LC R C C G+ L D
Sbjct: 2132 VPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGRGQRACACAHGM-LAED 2190
Query: 600 KKTCVEPEAFLVYSRKNIIGRLSIKNE--YNDAVIPIKD---LKEVSALAL-YVSGS--- 650
+C E +L+YS + I+ + + +E N V P +D +K V ALA Y +G+
Sbjct: 2191 GASCREYAGYLLYSERTILKSIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPG 2250
Query: 651 ---KLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVS 707
++++SD I + + +GS IVE +G VEGLA +YWT TT I
Sbjct: 2251 TPNRIFFSDIHFGNIQQINDDGSRRITIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRH 2310
Query: 708 RLD----GSSRR--AIIWQGLKKPKSIVLDPKKGYMYWSELGSK--SIKRAAMDGSSVSV 759
+D G+ R I G P++ VLD + M+W+ + SI RAA+ G++V
Sbjct: 2311 TVDQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLT 2370
Query: 760 FMEQVGRV-HALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPM-PYALALFND 817
+E+ R + LAID+ +Y++ +E +G+ R + + P+ P+ LA++ +
Sbjct: 2371 LIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGE 2430
Query: 818 SVYWGDWNTGQIQQARKTDGSNRKSIRKDLDY--ISDLKLYHRAKSMGSNQCGVDNGGCS 875
++W DW +Q+A K GSN K +R D+ + + + + S + C ++NGGC
Sbjct: 2431 HIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQ 2490
Query: 876 HLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVANGECNDAY 935
LCL T + C+C R+ +D++TC + + A ANGEC +
Sbjct: 2491 DLCLLTH---QGHVNCSCRGG-RILQDDLTCR-----AVNSSCRAQDEFECANGECINFS 2541
Query: 936 IPLTGLKNVR 945
+ G+ + +
Sbjct: 2542 LTCDGVPHCK 2551
Score = 377 bits (927), Expect = e-103
Identities = 252/876 (28%), Positives = 418/876 (47%), Gaps = 50/876 (5%)
Query: 253 ISAEDYPCKKNNAGCSHL-CLLSPDPPGYN--CACPTGVKLR-ENSSTTCYDSPQMLLVV 308
+ +++ C+ + HL C D ++ C+C G L + S D + ++
Sbjct: 1214 LGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFIIF 1273
Query: 309 AQRSTISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARL--DG 366
+ R I +I L D Y++ + L+ T+ +DF +YW D + I + +L +G
Sbjct: 1274 SNRHEIRRIDLHKGD---YSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNG 1330
Query: 367 ---SDQSVVVRSSGVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPR 423
S + V+ P+ +A+D ++ IYW + +D I VA+LDG+ ++ ++ PR
Sbjct: 1331 ALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPR 1390
Query: 424 AIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLT--WPNSIALDTVNNKLYW 481
AIAL G +FW+DW+ P+IE A++ G+GR + E + WPN + +D + ++ W
Sbjct: 1391 AIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEKRILW 1450
Query: 482 GDARTHKIEVCNMDGTERKE-LHSNDII-HIFGXXXXXXXXXXXXMQKRTLDRINKNTGL 539
DAR+ I DG+ E L ++ + H F + TL + NK TG
Sbjct: 1451 IDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGH 1510
Query: 540 DRQPVVEQMANMMGVKAFRLG-APLGWNPCADDNGG---CSHLC-FNRPDDYICGCPLGL 594
+ V ++ + P+ NPC + NGG CSHLC N C CP +
Sbjct: 1511 NVTVVQRTNTQPFDLQVYHPSRQPMAPNPC-EANGGQGPCSHLCLINYNRTVSCACPHLM 1569
Query: 595 ELTADKKTCVEPEAFLVYSRKNIIGRLSIKNEYNDAVI--PIKDLKEVSALALYVSGSKL 652
+L D TC E + FL+Y+R+ I + + Y + +I + D+ V+ L ++
Sbjct: 1570 KLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVLDYDAREQRV 1629
Query: 653 YWSDSKTKTINRCSVNGSAVEKIVEW-LGLVEGLAIDWSGQNIYWT--DTTTQRIEVSRL 709
YWSD +T+ I R +NG+ VE +V L GLA+DW +N++WT DT ++I V+RL
Sbjct: 1630 YWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARL 1689
Query: 710 DGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKSIKRAAMDGSS-VSVFMEQVGRVH 768
DGS + A++ QGL++P +V+ P +G +YW++ +I A MDGS+ +F Q G V
Sbjct: 1690 DGSFKNAVV-QGLEQPHGLVVHPLRGKLYWTD--GDNISMANMDGSNRTLLFSGQKGPV- 1745
Query: 769 ALAIDYERRAIYWAALDPPVVEFAFLNGTGRQ---TLADNIPMPYALALFNDSVYWGDWN 825
LAID+ +YW + + L+G+G + + + ALA+ D ++W D
Sbjct: 1746 GLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKLWWADQV 1805
Query: 826 TGQIQQARKTDGSNRKSIRKDLDYISDLKLYHRAKSM---GSNQCGVDNGGCSHLCLPTP 882
+ ++ K DGS +R + +K+Y + + G+N C V+NG CS LCLPT
Sbjct: 1806 SEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQLCLPTS 1865
Query: 883 GDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVANGECNDAYIPLTGLK 942
R+ C C A Y L C FLL++ + I + + +DA +P++G
Sbjct: 1866 ETTRS---CMCTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSGTS 1922
Query: 943 NVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGR 1002
I++ +YW+D +I R G+ R + +D +
Sbjct: 1923 LAVGIDFHAENDTIYWVDMGLSTISR-----AKRDQTWREDVVTNGIGRVEGIAVDWIAG 1977
Query: 1003 TMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGR-GAIMRA 1061
+YWT D I + N S V++ PR + H K YL W + G+ I R+
Sbjct: 1978 NIYWTDQGFDVIEVARL-NGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERS 2036
Query: 1062 NVDGTGRVELARADNA--TALALDQSAGTVYWAVSR 1095
+DGT RV L + +++D G +YW +R
Sbjct: 2037 RLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDAR 2072
Score = 260 bits (637), Expect = 2e-68
Identities = 201/717 (28%), Positives = 342/717 (47%), Gaps = 62/717 (8%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLR-ENSSTTCYDSP---QMLLVVAQRSTISKISLDSP 322
CS LC + + C C G L+ +N S + P +L++A I L
Sbjct: 160 CSQLCTNTDG--SFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGA 217
Query: 323 DFTPYTLPLKDLKRTLTVDFDPKTEYIYWA---DGLAKTISK-ARLDGS----DQSVVVR 374
+ T+ ++T +DF E + W D A+T K AR+ G D+ +
Sbjct: 218 QVS--TITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINI 275
Query: 375 SSGVP--DSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAG 432
S + + +AID L+ Y+ D + D I V +G ++ ELY+P+ IAL G
Sbjct: 276 SLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMG 335
Query: 433 WMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVC 492
+F++D+ + PK+ER ++DG R L+ K+ +P+ I LD V+ +YW DA IEV
Sbjct: 336 KVFFTDYGQI-PKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVV 394
Query: 493 NMDGTERKELHSNDII-HIFGXX------XXXXXXXXXXMQKRTLDRINKNTGLDRQPVV 545
+ +G R+ + +I H++G QK ++ R+N+ + Q V
Sbjct: 395 DYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVT 454
Query: 546 E-QMANMMGVKAFRLGAPLGWNPCADDN----GGCSHLCF--NRPDDYICGCPLGLELTA 598
+ + R + + C +D GGCS +C N C C G L +
Sbjct: 455 RVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGS 514
Query: 599 DKKTCVEP--EAFLVY--SRKNIIGRLSIKNEYNDA-VIPIKDLKEVSALALYVSGSKLY 653
D K+C +P E FLVY R II + + + D +IPI++L AL + +Y
Sbjct: 515 DGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIY 574
Query: 654 WSDSKTKTINRCSVNGSAVEKIV-EWLGLVEGLAIDWSGQNIYWTDTTTQR-IEVSRLD- 710
++D+ + I R ++G+ E I+ + + VEG+A+DW G N+YWTD ++ I V+RL+
Sbjct: 575 FADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEK 634
Query: 711 -GSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSK-------SIKRAAMDGSSVSVFM- 761
+R+ +I + P++IV+DP G+MYW++ ++RA MDGS +F+
Sbjct: 635 AAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVT 694
Query: 762 -EQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPMPYALAL--FNDS 818
+ V + L++D +YW +E LNGT R+ + + + +A L +
Sbjct: 695 SKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGNY 754
Query: 819 VYWGDWNTGQIQQARKTDGSNRKSI---RKDLDYISDLKLYH-RAKSMGSNQCGVDNGGC 874
++W ++ +G + + + G ++ R + I ++++Y + + +G+N+C V+NGGC
Sbjct: 755 LFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGGC 814
Query: 875 SHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVANGEC 931
S LCL TPG +CAC L+ D +TC ++ Q G AN C
Sbjct: 815 SSLCLATPG----SRQCACAEDQVLDADGVTCLANPSYVPPPQCQP-GEFACANSRC 866
Score = 255 bits (625), Expect = 6e-67
Identities = 176/636 (27%), Positives = 312/636 (49%), Gaps = 38/636 (5%)
Query: 9 RITTIAK-DLEQGTAVDFHYRKNLICW---SDQKPEL-IQC--MNYNETYTGEKFKIVSE 61
+++TI Q TA+DF Y +CW D + ++C M + + E +S
Sbjct: 218 QVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISL 277
Query: 62 GLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLM 121
L +AIDW T Y+ D ++I V + L E+ + IA+ P G +
Sbjct: 278 SLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKV 337
Query: 122 FWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVID 181
F+TD+G+IPK+ER M+G T+ +V I +P+GIT+D + L+YW DA L +++V+D
Sbjct: 338 FFTDYGQIPKVERCDMDGQNRTK--LVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVD 395
Query: 182 FNGEKRKRVVKGGLV-YPFALTFSNDKLYWTDWQNWSIY--TWDIAANGPKIKE--LIKS 236
+ G+ R+ +++G L+ + + LT + LY T+ N + T I N E ++
Sbjct: 396 YEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVTR 455
Query: 237 HPVPADIKVYDESRQIISAEDYPCKKNN----AGCSHLCLLSPDPPGYNCACPTGVKLRE 292
+ +Y + RQ + C+ + GCS +CLL+ C C +G L
Sbjct: 456 VDKGGALHIYHQRRQ-PRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGS 514
Query: 293 NSSTTCYDSPQMLLVV--AQRSTISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIY 350
+ + ++ LV + I + + + + +P+++L +DF +T +IY
Sbjct: 515 DGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIY 574
Query: 351 WADGLAKTISKARLDGSDQSVVVRSSGV--PDSIAIDPLSRKIYWTDP-VMDTINVARLD 407
+AD + I + ++DG+++ +++ G+ + +A+D + +YWTD TI+VARL+
Sbjct: 575 FADTTSYLIGRQKIDGTERETILK-DGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLE 633
Query: 408 GSYE--KVIIHTELYDPRAIALHLTAGWMFWSDWNE-----KKPKIERANLDGSGRVLLI 460
+ + K +I ++ PRAI + GWM+W+DW E ++ ++ERA +DGS R + +
Sbjct: 634 KAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFV 693
Query: 461 SEK-LTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSN-DIIHIFGXXXXXX 518
+ K + WPN ++LD +LYW DA +IE ++GT+RK ++ ++ H FG
Sbjct: 694 TSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGN 753
Query: 519 XXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFRL----GAPLGWNPCADDNGG 574
+ ++ R+ + G V + + R+ +G N C +NGG
Sbjct: 754 YLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGG 813
Query: 575 CSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFL 610
CS LC P C C L AD TC+ +++
Sbjct: 814 CSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYV 849
Score = 219 bits (534), Expect = 6e-56
Identities = 125/345 (36%), Positives = 191/345 (55%), Gaps = 19/345 (5%)
Query: 575 CSHLCFNRPDDYICGCPLGLELTA-DKKTC---VEPEAFLVYSRKNIIGRLSIKNEYNDA 630
CS C N Y C C G D +C + E FL+++ + + +L++ N
Sbjct: 2992 CSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGS-NYT 3050
Query: 631 VIPIKDLKEVSALALYVSGSKLYWSDSKTK--TINRCSVNGSAVEKIVEWLGLV--EGLA 686
++ + L AL +YW+D T+ I R +NGS V+ ++ GL +GLA
Sbjct: 3051 LLK-QGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQ-VLHRTGLSNPDGLA 3108
Query: 687 IDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS 746
+DW G N+YW D IEVS+L+G+ R ++ GL++P+++V+D + GY+YW++ G S
Sbjct: 3109 VDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHS 3168
Query: 747 -IKRAAMDGSSVSVFME-QVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQ-TLA 803
I R MDGSS SV ++ ++ + L +DY IYWA +EFA L+G+ R L+
Sbjct: 3169 LIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLS 3228
Query: 804 DNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYH--RAKS 861
+IP +AL LF D VYW DW T I +A KT G+N+ + L DL ++H R
Sbjct: 3229 QDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPD 3288
Query: 862 MGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
+ ++ C V+NGGCS+LCL +PG ++CACP ++ L D TC
Sbjct: 3289 VPNHPCKVNNGGCSNLCLLSPGG---GHKCACPTNFYLGSDGRTC 3330
Score = 206 bits (503), Expect = 4e-52
Identities = 111/346 (32%), Positives = 182/346 (52%), Gaps = 14/346 (4%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLRENSSTTC--YDSPQMLLVVAQRSTISKISLDSPDF 324
CS C+ + Y C C G R +C + L+ A R + K++LD +
Sbjct: 2992 CSQRCINTHG--SYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSN- 3048
Query: 325 TPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAK--TISKARLDGSDQSVVVRSS-GVPDS 381
YTL + L + +DFD + + IYW D + I + L+GS+ V+ R+ PD
Sbjct: 3049 --YTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDG 3106
Query: 382 IAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNE 441
+A+D + +YW D DTI V++L+G+Y V++ + L +PRA+ + + G+++W+DW +
Sbjct: 3107 LAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGD 3166
Query: 442 KKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKE 501
I R +DGS R +++ K+TWPN + LD V ++YW DAR IE ++DG+ R
Sbjct: 3167 HS-LIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHV 3225
Query: 502 LHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFR-LG 560
+ S DI HIF + ++++R +K TG ++ ++ + M + F L
Sbjct: 3226 VLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALR 3285
Query: 561 AP-LGWNPCADDNGGCSHLCFNRP-DDYICGCPLGLELTADKKTCV 604
P + +PC +NGGCS+LC P + C CP L +D +TCV
Sbjct: 3286 QPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCV 3331
Score = 197 bits (481), Expect = 2e-49
Identities = 109/289 (37%), Positives = 156/289 (53%), Gaps = 12/289 (4%)
Query: 11 TTIAKDLEQGTAVDFHYRKNLICWSDQKPE--LIQCMNYNETYTGEKFKIVSE-GLVTPT 67
T + + L A+DF YR+ +I W+D + +I+ M+ N G +++ GL P
Sbjct: 3050 TLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLN----GSNVQVLHRTGLSNPD 3105
Query: 68 GIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWG 127
G+A+DW LYW D + IEV + YR VL S + RA+ V ++G ++WTDWG
Sbjct: 3106 GLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWG 3165
Query: 128 EIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKR 187
+ I R GM+G ++R VIV I WPNG+T+DY IYW DA+ +++ +G R
Sbjct: 3166 DHSLIGRIGMDG--SSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNR 3223
Query: 188 KRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYD 247
V+ + + FALT D +YWTDW+ SI G LI + P D+ V+
Sbjct: 3224 HVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAH-KTTGTNKTLLISTLHRPMDLHVFH 3282
Query: 248 ESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSST 296
RQ ++PCK NN GCS+LCLLSP G+ CACPT L + T
Sbjct: 3283 ALRQ-PDVPNHPCKVNNGGCSNLCLLSPG-GGHKCACPTNFYLGSDGRT 3329
Score = 153 bits (370), Expect = 5e-36
Identities = 89/243 (36%), Positives = 122/243 (50%), Gaps = 12/243 (4%)
Query: 62 GLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLM 121
GL P GIAIDW +YWTD + IEV + + RK L +D AI V P G M
Sbjct: 3956 GLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTM 4015
Query: 122 FWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVID 181
+W+DWG PKIE A M+G R+ +V+DNI WP G+ VDY+N +YW DAKL + I
Sbjct: 4016 YWSDWGNHPKIETAAMDG--TLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIR 4073
Query: 182 FNGEKRKRVV--KGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPV 239
NG K GL +PF++ D +Y + N ++ + P + L
Sbjct: 4074 LNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLV-NLTGGLSH 4132
Query: 240 PADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCY 299
+D+ +Y + +Q PC + C LCLLSP P C CP G +L +N +
Sbjct: 4133 ASDVVLYHQHKQ--PEVTNPCDRKK--CEWLCLLSPSGP--VCTCPNGKRL-DNGTCVPV 4185
Query: 300 DSP 302
SP
Sbjct: 4186 PSP 4188
Score = 148 bits (358), Expect = 1e-34
Identities = 142/568 (25%), Positives = 238/568 (41%), Gaps = 59/568 (10%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTCV-------EPEAFLVYSRKNIIGRLSIKN 625
G CS LC N +ICGC G L D ++C P L+ + +NI+ +
Sbjct: 158 GTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATY-LSG 216
Query: 626 EYNDAVIPIKDLKEVSALALYVSGSKLYW---SDSKTKTINRCS----VNGSAVEKIVE- 677
+ P ++ +A+ + + W DS +T +C+ + G E +
Sbjct: 217 AQVSTITP-TSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINI 275
Query: 678 --WLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKG 735
L VE +AIDW N Y+ D RI V +G + ++ L PK I LDP G
Sbjct: 276 SLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMG 335
Query: 736 YMYWSELGS-KSIKRAAMDGSSVSVFME-QVGRVHALAIDYERRAIYWAALDPPVVEFAF 793
+++++ G ++R MDG + + ++ ++ H + +D R +YWA +E
Sbjct: 336 KVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVD 395
Query: 794 LNGTGRQTLADNIPMP--YALALFNDSVYWGDWNTGQIQQARKTDGSNR-----KSIRKD 846
G GRQT+ I + Y L +F + +Y + + QQ NR +
Sbjct: 396 YEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVTR 455
Query: 847 LDYISDLKLYH--RAKSMGSNQCGVDN----GGCSHLC-LPTPGDVRTDYRCACPAHYRL 899
+D L +YH R + S+ C D GGCS +C L RT C C + + L
Sbjct: 456 VDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKART---CRCRSGFSL 512
Query: 900 NKDNITCSEPEE--FLLFAQ-KNAVGRIMVANGECNDAY-IPLTGLKNVRAIEYDPVEKQ 955
D +C +PE FL++ + + + R M + D + IP+ L N RA+++
Sbjct: 513 GSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGF 572
Query: 956 LYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWT-CADRDSI 1014
+Y+ D S+ I R I G+ + +D +G +YWT + +I
Sbjct: 573 IYFADTTSYLIGRQKID-----GTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTI 627
Query: 1015 NATSIDNNSST-GVIVRGDRMLPRHLAFHQTKRYLIW-------NDVGRGAIMRANVDGT 1066
+ ++ + T ++ G PR + ++ W D RG + RA +DG+
Sbjct: 628 SVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGS 687
Query: 1067 GRVELARADNA---TALALDQSAGTVYW 1091
R + L+LD AG +YW
Sbjct: 688 HRDIFVTSKTVLWPNGLSLDIPAGRLYW 715
Score = 135 bits (326), Expect = 1e-30
Identities = 102/360 (28%), Positives = 169/360 (46%), Gaps = 35/360 (9%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVY-SRKNIIGRLSIKNEYN--D 629
G CS LC N ++C C T + E ++Y + N I L + ++ +
Sbjct: 3832 GTCSQLCNNTKGGHLCSCARNFMKTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYE 3891
Query: 630 AVIPIKDLKEVSALALYVSGSKLYWSDSKTKTIN----------------RCSVNGSAVE 673
+ + A+ ++V ++YW++ T TI+ R ++
Sbjct: 3892 QAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTH 3951
Query: 674 KIVEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPK 733
+ L + G+AIDW N+YWTD+ IEV+++ G +R+ +I + +P +IV+DP
Sbjct: 3952 LNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPL 4011
Query: 734 KGYMYWSELGS-KSIKRAAMDGS-SVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEF 791
+G MYWS+ G+ I+ AAMDG+ ++ + + LA+DY +YWA V+
Sbjct: 4012 RGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGS 4071
Query: 792 AFLNGTGRQTLADN---IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLD 848
LNGT AD+ + P+++ +F D +Y + ++ + K S ++ L
Sbjct: 4072 IRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLS 4131
Query: 849 YISDLKLYHRAKSMG-SNQCGVDNGGCSHLCLPTP-GDVRTDYRCACPAHYRLNKDNITC 906
+ SD+ LYH+ K +N C D C LCL +P G V C CP RL DN TC
Sbjct: 4132 HASDVVLYHQHKQPEVTNPC--DRKKCEWLCLLSPSGPV-----CTCPNGKRL--DNGTC 4182
Score = 111 bits (268), Expect = 1e-23
Identities = 96/359 (26%), Positives = 151/359 (42%), Gaps = 30/359 (8%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDSPDFTP 326
CS LC + G+ C+C ++ +++ S +L +A + I + P +
Sbjct: 3834 CSQLC--NNTKGGHLCSCARNF-MKTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPH-SA 3889
Query: 327 YTLPLK--DLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGS-------------DQSV 371
Y + + R +D K +YW + TIS L + D+ V
Sbjct: 3890 YEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGV 3949
Query: 372 V-VRSSGV--PDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALH 428
+ SG+ P IAID ++ +YWTD D I VA++ G K +I + +P AI +
Sbjct: 3950 THLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVD 4009
Query: 429 LTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHK 488
G M+WSDW PKIE A +DG+ R L+ + + WP +A+D N +LYW DA+
Sbjct: 4010 PLRGTMYWSDWG-NHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSV 4068
Query: 489 IEVCNMDGTER--KELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVE 546
I ++GT+ + H F + +I+K +
Sbjct: 4069 IGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTG 4128
Query: 547 QMANMMGVKAF-RLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
+++ V + + P NPC D C LC P +C CP G L D TCV
Sbjct: 4129 GLSHASDVVLYHQHKQPEVTNPC--DRKKCEWLCLLSPSGPVCTCPNGKRL--DNGTCV 4183
Score = 93.9 bits (223), Expect = 3e-18
Identities = 81/254 (31%), Positives = 130/254 (51%), Gaps = 21/254 (8%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDS-PQMLLVVAQRSTISKIS 318
C NN GCSH C ++P G C+CP G++L ++ T S L +Q+ +K S
Sbjct: 1185 CSLNNGGCSHNCSVAPG-EGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFS 1243
Query: 319 LDSPDFTPYTL-PLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSG 377
+ + + L P + R+L DP +I +++ I + L D SV+V G
Sbjct: 1244 VKCSCYEGWVLEPDGESCRSL----DPFKPFIIFSN--RHEIRRIDLHKGDYSVLV--PG 1295
Query: 378 VPDSIAID-PLSRK-IYWTDPVMDTINVARL--DGSYE--KVIIHTELYDPRAIALHLTA 431
+ ++IA+D LS+ +YWTD V D I +L +G+ +V+I L P +A+ A
Sbjct: 1296 LRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIA 1355
Query: 432 GWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYW--GDARTHKI 489
G ++W + N +IE A LDG+ R L++ + P +IALD + L+W DA +I
Sbjct: 1356 GNIYWVESN--LDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRI 1413
Query: 490 EVCNMDGTERKELH 503
E +M G R+ +H
Sbjct: 1414 EAASMSGAGRRTVH 1427
Score = 87.0 bits (206), Expect = 4e-16
Identities = 79/302 (26%), Positives = 135/302 (44%), Gaps = 25/302 (8%)
Query: 568 CADDNGGCSHLCFNRPDD-YICGCPLGLELTADKKTC-VEP--EAFLVYSRKNIIGRLSI 623
C+ +NGGCSH C P + +C CPLG+EL D TC ++ L S+K + S+
Sbjct: 1185 CSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSV 1244
Query: 624 KNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVE 683
K + + D + +L + K + S I R ++ +V GL
Sbjct: 1245 KCSCYEGWVLEPDGESCRSLDPF----KPFIIFSNRHEIRRIDLHKGDYSVLVP--GLRN 1298
Query: 684 GLAIDW--SGQNIYWTDTTTQRIEVSRL--DG--SSRRAIIWQGLKKPKSIVLDPKKGYM 737
+A+D+ S +YWTD +I +L +G +S +I GL P+ + +D G +
Sbjct: 1299 TIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNI 1358
Query: 738 YWSELGSKSIKRAAMDGS-SVSVFMEQVGRVHALAIDYERRAIYWAALDP--PVVEFAFL 794
YW E I+ A +DG+ ++ + A+A+D ++W D P +E A +
Sbjct: 1359 YWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASM 1418
Query: 795 NGTGRQTL-----ADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDY 849
+G GR+T+ + P + + W D + I AR DGS + + ++
Sbjct: 1419 SGAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSAR-YDGSGHMEVLRGHEF 1477
Query: 850 IS 851
+S
Sbjct: 1478 LS 1479
Score = 75.4 bits (177), Expect = 1e-12
Identities = 63/232 (27%), Positives = 102/232 (43%), Gaps = 22/232 (9%)
Query: 874 CSHLCLPTPGDVRTDYRCACPAHYR-LNKDNITC---SEPEEFLLFAQKNAVGRIMVANG 929
CS C+ T G Y+C C Y D +C ++ E FL+FA + + ++ N
Sbjct: 2992 CSQRCINTHGS----YKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKL---NL 3044
Query: 930 ECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHS--IRRVPISYXXXXXXXXXXXXXX 987
+ ++ + GL N A+++D E+ +YW D + IRR+ ++
Sbjct: 3045 DGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLN-----GSNVQVLHRT 3099
Query: 988 GLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRY 1047
GLS P + +D +G +YW RD+I + + N + V+V PR L Y
Sbjct: 3100 GLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKL-NGAYRTVLVSSGLREPRALVVDVQNGY 3158
Query: 1048 LIWNDVG-RGAIMRANVDGTGRVEL--ARADNATALALDQSAGTVYWAVSRQ 1096
L W D G I R +DG+ R + + L LD +YWA +R+
Sbjct: 3159 LYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADARE 3210
Score = 65.3 bits (152), Expect = 1e-09
Identities = 62/235 (26%), Positives = 97/235 (41%), Gaps = 22/235 (9%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC---SEPEEFLLFAQKNAV 921
+QC ++NGGCSH C PG+ C+CP L DN TC S + L +QK
Sbjct: 1183 DQCSLNNGGCSHNCSVAPGE---GIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQ 1239
Query: 922 GRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXX 981
+ V C + ++ ++ R++ DP + + + + H IRR+ +
Sbjct: 1240 NKFSV-KCSCYEGWVLEPDGESCRSL--DPFKPFIIF--SNRHEIRRIDLHKGDYSVLVP 1294
Query: 982 XXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSI-NATSIDNNSSTG--VIVRGDRMLPRH 1038
L +H+ L YWT D I +DN + T V+++ P
Sbjct: 1295 GLRNTIALD--FHLSQSAL----YWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEG 1348
Query: 1039 LAFHQTKRYLIWNDVGRGAIMRANVDGTGRVELARAD--NATALALDQSAGTVYW 1091
LA + W + I A +DGT R L D + A+ALD G ++W
Sbjct: 1349 LAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFW 1403
Score = 64.9 bits (151), Expect = 2e-09
Identities = 48/186 (25%), Positives = 82/186 (44%), Gaps = 11/186 (5%)
Query: 35 SDQKPELIQCMNY---NETYTGEKFKIVSEGLVTPTGIAIDWYTDKLYWTDGET--NKIE 89
+D++P LI Y G + ++ +GL + D+ +YWTD T + I
Sbjct: 3025 TDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIR 3084
Query: 90 VISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERAGMNGDPATRKVIVR 149
+ + +VL + + +AV G ++W D G IE + +NG A R V+V
Sbjct: 3085 RMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGR-DTIEVSKLNG--AYRTVLVS 3141
Query: 150 DNIFWPNGITVDYNNSLIYWVD-AKLQFVDVIDFNGEKRKRVVKGGLVYPFALT--FSND 206
+ P + VD N +YW D + I +G R +V + +P LT + +
Sbjct: 3142 SGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTE 3201
Query: 207 KLYWTD 212
++YW D
Sbjct: 3202 RIYWAD 3207
Score = 56.4 bits (130), Expect = 6e-07
Identities = 60/252 (23%), Positives = 92/252 (36%), Gaps = 18/252 (7%)
Query: 933 DAYIPLTGLKNVRAIEYDPVEKQLYWMD-DDSH-SIRRVPISYXXXXXXXXXXXXXXGLS 990
+ I ++G + RA D + ++W + ++ H SI R +S +
Sbjct: 2323 ETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALS-----GANVLTLIEKDIR 2377
Query: 991 RPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIW 1050
P + +D +Y++ A D I D S VI++ + + P LA + ++ W
Sbjct: 2378 TPNGLAIDHRAEKLYFSDATLDKIERCEYDG-SHRYVILKSEPVHPFGLAVYG--EHIFW 2434
Query: 1051 NDVGRGAIMRANVDGTGRVELARADNATALALDQSAGTVYWAVSRQCDGQQDCE--DGRD 1108
D R A+ RAN ++L R D Q G + A C +G
Sbjct: 2435 TDWVRRAVQRANKHVGSNMKLLRVDIP-----QQPMGIIAVANDTNSCELSPCRINNGGC 2489
Query: 1109 EAECGACG-GDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQ 1167
+ C G V C+ D F C G CI CDG P
Sbjct: 2490 QDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFECANGECINFSLTCDGVPH 2549
Query: 1168 CADGSDEAPAAC 1179
C D SDE P+ C
Sbjct: 2550 CKDKSDEKPSYC 2561
Score = 52.0 bits (119), Expect = 1e-05
Identities = 49/170 (28%), Positives = 60/170 (35%), Gaps = 8/170 (4%)
Query: 923 RIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXX 982
R M NG N + TGL N + D V LYW D R I
Sbjct: 3084 RRMHLNGS-NVQVLHRTGLSNPDGLAVDWVGGNLYWCDKG-----RDTIEVSKLNGAYRT 3137
Query: 983 XXXXXGLSRPYHMVLDVLGRTMYWT-CADRDSINATSIDNNSSTGVIVRGDRMLPRHLAF 1041
GL P +V+DV +YWT D I +D SS VIV P L
Sbjct: 3138 VLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDG-SSRSVIVDTKITWPNGLTL 3196
Query: 1042 HQTKRYLIWNDVGRGAIMRANVDGTGRVELARADNATALALDQSAGTVYW 1091
+ W D I A++DG+ R + D AL VYW
Sbjct: 3197 DYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYW 3246
Score = 51.6 bits (118), Expect = 2e-05
Identities = 63/253 (24%), Positives = 89/253 (35%), Gaps = 22/253 (8%)
Query: 945 RAIEYDPVEKQLYWMD--DDSHSIRRVPISYX-XXXXXXXXXXXXXGLSRPYHMVLDVLG 1001
RAI DP+ +YW D +D RR + + P + LD+
Sbjct: 651 RAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPA 710
Query: 1002 RTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGAIMRA 1061
+YW A D I T + N + ++ G + H YL W + G++ R
Sbjct: 711 GRLYWVDAFYDRIE-TILLNGTDRKIVYEGPELNHAFGLCHHGN-YLFWTEYRSGSVYRL 768
Query: 1062 N--VDGTG-RVELARADNATALALDQSAGTVYWAVSRQCDGQQDCE--DGRDEAECGACG 1116
V G V L R++ + +Y A +Q G C +G + C A
Sbjct: 769 ERGVGGAPPTVTLLRSERPPIFEI-----RMYDAQQQQV-GTNKCRVNNGGCSSLCLATP 822
Query: 1117 GDVRCADGTXXXXXXXXXXXXXXXXXX-----XXDAFRCDEGLCIAARFVCDGRPQCADG 1171
G +CA F C CI R+ CDG C D
Sbjct: 823 GSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDN 882
Query: 1172 SDEAPAACAYGHT 1184
SDEAPA C + HT
Sbjct: 883 SDEAPALC-HQHT 894
Score = 50.8 bits (116), Expect = 3e-05
Identities = 33/100 (33%), Positives = 38/100 (38%), Gaps = 16/100 (16%)
Query: 1096 QCDGQQDCEDGRDEAECGA---------CGGDVRC------ADGTXXXXXXXXXXXXXXX 1140
+C+GQ +C DG DE +C C RC D
Sbjct: 3432 RCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQ 3491
Query: 1141 XXXXXDAFRC-DEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
D FRC D G CI AR+ CDG C DGSDE C
Sbjct: 3492 MTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEEC 3531
Score = 48.4 bits (110), Expect = 2e-04
Identities = 39/114 (34%), Positives = 42/114 (36%), Gaps = 30/114 (26%)
Query: 1093 VSRQ--CDGQQDCEDGRDEAE------CGA-----------------CGGDVRCADGTXX 1127
+S+Q CDG DC DG DEA CG C GD CADG
Sbjct: 2747 ISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADE 2806
Query: 1128 XXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAACAY 1181
F C CI FVCD CADGSDE+P C Y
Sbjct: 2807 SIAAGCLYNSTCDDRE----FMCQNRQCIPKHFVCDHDRDCADGSDESP-ECEY 2855
Score = 48.0 bits (109), Expect = 2e-04
Identities = 28/83 (33%), Positives = 32/83 (38%), Gaps = 2/83 (2%)
Query: 1094 SRQCDGQQ-DCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCD- 1151
S C Q C GR E C GD C D + D F+C
Sbjct: 1012 SHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRL 1071
Query: 1152 EGLCIAARFVCDGRPQCADGSDE 1174
+GLCI R+ CDG C D SDE
Sbjct: 1072 DGLCIPLRWRCDGDTDCMDSSDE 1094
Score = 48.0 bits (109), Expect = 2e-04
Identities = 30/99 (30%), Positives = 35/99 (35%), Gaps = 14/99 (14%)
Query: 1096 QCDGQQDCEDGRDEAECGA-CGGDV-------------RCADGTXXXXXXXXXXXXXXXX 1141
+CDG DC DG DE +C C D RC
Sbjct: 3593 KCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVR 3652
Query: 1142 XXXXDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAACA 1180
D F+C+ LC + CDG C D SDE P CA
Sbjct: 3653 TCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECA 3691
Score = 47.2 bits (107), Expect = 4e-04
Identities = 32/107 (29%), Positives = 43/107 (40%), Gaps = 15/107 (14%)
Query: 1093 VSRQCDGQQDCEDGRDEAECGACGGDV-------RC------ADGTXXXXXXXXXXXXXX 1139
+S CD + DCE G DE C + RC DG+
Sbjct: 2711 MSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCE 2770
Query: 1140 XXXXXXDAFRCD-EGLCIAARFVCDGRPQCADGSDEAPAA-CAYGHT 1184
+F C +C+ R++CDG CADG+DE+ AA C Y T
Sbjct: 2771 GKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNST 2817
Score = 43.6 bits (98), Expect = 0.004
Identities = 32/95 (33%), Positives = 36/95 (37%), Gaps = 17/95 (17%)
Query: 1096 QCDGQQDCEDGRDEA--ECGA---------CGGDVRCADGTXXXXXXXXXXXXXXXXXXX 1144
+CDG+ DC DG DE EC C + RC G
Sbjct: 3513 KCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNN-RCVPGRWQCDYDNDCGDNSDEESCT 3571
Query: 1145 -----XDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
F C G CIA R+ CDG CADGSDE
Sbjct: 3572 PRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDE 3606
Score = 43.2 bits (97), Expect = 0.006
Identities = 25/86 (29%), Positives = 35/86 (40%), Gaps = 7/86 (8%)
Query: 1096 QCD-GQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGL 1154
QC G+ C + R E C GD C D + D F+C+
Sbjct: 853 QCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPS------DRFKCENNR 906
Query: 1155 CIAARFVCDGRPQCADGSDEAPAACA 1180
CI R++CDG C + DE+ A C+
Sbjct: 907 CIPNRWLCDGDNDCGNSEDESNATCS 932
Score = 41.9 bits (94), Expect = 0.013
Identities = 18/44 (40%), Positives = 21/44 (47%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAACAYGHTDQVNGIH 1191
F+C+ G CI + CDG C D SDE A C T G H
Sbjct: 1020 FKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCH 1063
Score = 40.7 bits (91), Expect = 0.031
Identities = 33/101 (32%), Positives = 37/101 (36%), Gaps = 23/101 (22%)
Query: 1097 CDGQQDCEDGRDEAECG--ACG-GDVRCADGTXXXXXX---------XXXXXXXXXXXXX 1144
C+G DC DG DE C ACG G+ RC DGT
Sbjct: 2585 CNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDC 2644
Query: 1145 XDAFR----------CDE-GLCIAARFVCDGRPQCADGSDE 1174
FR C+ LC A +VCDG C D SDE
Sbjct: 2645 SSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDE 2685
Score = 39.5 bits (88), Expect = 0.071
Identities = 26/119 (21%), Positives = 47/119 (39%), Gaps = 1/119 (0%)
Query: 9 RITTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGL-VTPT 67
R T +A D+E A+ R ++ W+D L + + + G + G P
Sbjct: 1378 RTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPN 1437
Query: 68 GIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDW 126
G+ +D+ ++ W D ++ I + L+ AV G ++WTDW
Sbjct: 1438 GLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDW 1496
Score = 39.1 bits (87), Expect = 0.094
Identities = 17/33 (51%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 1148 FRC-DEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F C D+ CI+ + CDG C DGSDEAP C
Sbjct: 32 FACRDQITCISKGWRCDGERDCPDGSDEAPEIC 64
Score = 38.7 bits (86), Expect = 0.12
Identities = 29/100 (29%), Positives = 38/100 (38%), Gaps = 22/100 (22%)
Query: 1097 CDGQQDCEDGRDEA-ECG--ACG-GDVRCADGTXXXXXXXXXXXXXXXXXXXXDA----- 1147
CD +DC DG DE+ EC CG + RCA+G +A
Sbjct: 2837 CDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPH 2896
Query: 1148 -------------FRCDEGLCIAARFVCDGRPQCADGSDE 1174
F C G C+A +C+G+ C D SDE
Sbjct: 2897 CTSPEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDE 2936
Score = 38.7 bits (86), Expect = 0.12
Identities = 14/28 (50%), Positives = 17/28 (60%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEA 1175
F+C G+C F+CDG C D SDEA
Sbjct: 3379 FQCSTGICTNPAFICDGDNDCQDNSDEA 3406
Score = 38.3 bits (85), Expect = 0.16
Identities = 33/139 (23%), Positives = 53/139 (38%), Gaps = 7/139 (5%)
Query: 935 YIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYH 994
++ ++GLK R I D V +YW D R I + P+
Sbjct: 3951 HLNISGLKMPRGIAIDWVAGNVYWTDSG-----RDVIEVAQMKGENRKTLISGMIDEPHA 4005
Query: 995 MVLDVLGRTMYWT-CADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDV 1053
+V+D L TMYW+ + I ++D + +V+ + P LA L W D
Sbjct: 4006 IVVDPLRGTMYWSDWGNHPKIETAAMD-GTLRETLVQDNIQWPTGLAVDYHNERLYWADA 4064
Query: 1054 GRGAIMRANVDGTGRVELA 1072
I ++GT + A
Sbjct: 4065 KLSVIGSIRLNGTDPIVAA 4083
Score = 37.9 bits (84), Expect = 0.22
Identities = 16/30 (53%), Positives = 20/30 (66%), Gaps = 1/30 (3%)
Query: 1148 FRCDEGLCIAAR-FVCDGRPQCADGSDEAP 1176
FRC G C+++R + CDG C D SDEAP
Sbjct: 2863 FRCANGRCLSSRQWECDGENDCHDQSDEAP 2892
Score = 36.7 bits (81), Expect = 0.50
Identities = 25/82 (30%), Positives = 29/82 (35%), Gaps = 6/82 (7%)
Query: 1107 RDEAEC--GACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFR-CDEGLCIAARFVCD 1163
+DE EC G C DG FR C G C++ C+
Sbjct: 2527 QDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCN 2586
Query: 1164 GRPQCADGSDEAP---AACAYG 1182
G C DGSDE P AC G
Sbjct: 2587 GADDCGDGSDEIPCNKTACGVG 2608
Score = 35.9 bits (79), Expect = 0.87
Identities = 12/36 (33%), Positives = 24/36 (66%)
Query: 58 IVSEGLVTPTGIAIDWYTDKLYWTDGETNKIEVISI 93
+V + + PTG+A+D++ ++LYW D + + I I +
Sbjct: 4039 LVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRL 4074
Score = 35.5 bits (78), Expect = 1.2
Identities = 16/34 (47%), Positives = 19/34 (55%), Gaps = 1/34 (2%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAACAY 1181
F C G CI + CD C D SDE+ A+CAY
Sbjct: 941 FSCASGRCIPISWTCDLDDDCGDRSDES-ASCAY 973
Score = 35.1 bits (77), Expect = 1.5
Identities = 19/60 (31%), Positives = 27/60 (45%), Gaps = 2/60 (3%)
Query: 1035 LPRHLAFHQTKRYLIWNDVGRGAIMRANVDGTGRVELARA--DNATALALDQSAGTVYWA 1092
+PR +A + W D GR I A + G R L D A+ +D GT+YW+
Sbjct: 3959 MPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWS 4018
Score = 34.7 bits (76), Expect = 2.0
Identities = 32/113 (28%), Positives = 36/113 (31%), Gaps = 20/113 (17%)
Query: 1097 CDGQQDCEDGRDE-AECG--ACGGD-VRCADGTXXXXXXXXXXXXXXXXXXXXDA----- 1147
CD DC DG DE A C CG D RC D +
Sbjct: 3473 CDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECD 3532
Query: 1148 --------FRCDEGLCIAARFVCDGRPQCADGSDE---APAACAYGHTDQVNG 1189
FRC C+ R+ CD C D SDE P C+ NG
Sbjct: 3533 ERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANG 3585
Score = 33.5 bits (73), Expect = 4.7
Identities = 11/20 (55%), Positives = 14/20 (70%)
Query: 1093 VSRQCDGQQDCEDGRDEAEC 1112
+ RQCDG +C DG DE +C
Sbjct: 3712 IGRQCDGTDNCGDGTDEEDC 3731
Score = 33.1 bits (72), Expect = 6.2
Identities = 13/28 (46%), Positives = 15/28 (53%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEA 1175
F C+ G CI + CD C D SDEA
Sbjct: 982 FTCNNGRCININWRCDNDNDCGDNSDEA 1009
Score = 33.1 bits (72), Expect = 6.2
Identities = 33/173 (19%), Positives = 60/173 (34%), Gaps = 4/173 (2%)
Query: 922 GRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXX-XXXXX 980
G I N + + + + +V + Y LYW + +I R +
Sbjct: 2263 GNIQQINDDGSRRITIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFER 2322
Query: 981 XXXXXXXGLSRPYHMVLDVLGRTMYWTCADRD--SINATSIDNNSSTGVIVRGDRMLPRH 1038
G P VLD M+WT + SI ++ + ++ ++ D P
Sbjct: 2323 ETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAAL-SGANVLTLIEKDIRTPNG 2381
Query: 1039 LAFHQTKRYLIWNDVGRGAIMRANVDGTGRVELARADNATALALDQSAGTVYW 1091
LA L ++D I R DG+ R + +++ L ++W
Sbjct: 2382 LAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFW 2434
>AF058427-1|AAC64265.1| 4544|Homo sapiens lipoprotein receptor-related
protein protein.
Length = 4544
Score = 484 bits (1193), Expect = e-136
Identities = 334/1148 (29%), Positives = 569/1148 (49%), Gaps = 81/1148 (7%)
Query: 11 TTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSE-GLVTPTGI 69
+ + L A+DFH ++ + W+D + I + F++V + GL TP G+
Sbjct: 1290 SVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGL 1349
Query: 70 AIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDW-GE 128
A+DW +YW + ++IEV + R L +++ RAIA+ P DG++FWTDW
Sbjct: 1350 AVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDAS 1409
Query: 129 IPKIERAGMNGDPATRKVIVRD--NIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEK 186
+P+IE A M+G A R+ + R+ + WPNG+TVDY I W+DA+ + ++G
Sbjct: 1410 LPRIEAASMSG--AGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSG 1467
Query: 187 RKRVVKGG--LVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIK 244
V++G L +PFA+T ++YWTDW+ ++ + G + + +++ P D++
Sbjct: 1468 HMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKAN-KWTGHNVTVVQRTNTQPFDLQ 1526
Query: 245 VYDESRQIISAEDYPCKKN--NAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSP 302
VY SRQ ++ PC+ N CSHLCL++ + +CACP +KL ++ +TTCY+
Sbjct: 1527 VYHPSRQPMAPN--PCEANGGQGPCSHLCLINYNRT-VSCACPHLMKLHKD-NTTCYEFK 1582
Query: 303 QMLLVVAQRSTISKISLDSPDFT---PYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTI 359
+ LL A++ I + LD+P + +T+P D+ +D+D + + +YW+D + I
Sbjct: 1583 KFLL-YARQMEIRGVDLDAPYYNYIISFTVP--DIDNVTVLDYDAREQRVYWSDVRTQAI 1639
Query: 360 SKARLDGSDQSVVVRSSGVPDS--IAIDPLSRKIYWT--DPVMDTINVARLDGSYEKVII 415
+A ++G+ VV S+ +P++ +A+D +SR ++WT D INVARLDGS++ ++
Sbjct: 1640 KRAFINGTGVETVV-SADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV 1698
Query: 416 HTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTV 475
L P + +H G ++W+D + I AN+DGS R LL S + P +A+D
Sbjct: 1699 Q-GLEQPHGLVVHPLRGKLYWTDGD----NISMANMDGSNRTLLFSGQ-KGPVGLAIDFP 1752
Query: 476 NNKLYWGDARTHKIEVCNMDGT--ERKELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRI 533
+KLYW + H I CN+DG+ E + + + +
Sbjct: 1753 ESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTC 1812
Query: 534 NKNTGLDRQPVVEQMANMMGVKAFRLGAPL---GWNPCADDNGGCSHLCFNRPD-DYICG 589
+K G + +M +K + L G NPC+ +NG CS LC + C
Sbjct: 1813 SKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSCM 1872
Query: 590 CPLGLELTADKKTCVEPEAFLVYS-RKNIIGRLSIKNEYNDAVIPIKDLKEVSALALYVS 648
C G L + ++ C +FL+YS + I G N+ +DA++P+ + +
Sbjct: 1873 CTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAE 1932
Query: 649 GSKLYWSDSKTKTINRCSVNGSAVEKIV-EWLGLVEGLAIDWSGQNIYWTDTTTQRIEVS 707
+YW D TI+R + + E +V +G VEG+A+DW NIYWTD IEV+
Sbjct: 1933 NDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVA 1992
Query: 708 RLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGS-KSIKRAAMDGSSVSVFME-QVG 765
RL+GS R +I QGL KP++I + P+KGY++W+E G I+R+ +DG+ V + +
Sbjct: 1993 RLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSIS 2052
Query: 766 RVHALAIDYERRAIYWAALDPPVVEFAFL-NGTGRQ-TLADNIPMPYALALFNDSVYWGD 823
+ +++DY+ +YW +E L G R+ L+ N +++++F D +YW D
Sbjct: 2053 WPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSD 2112
Query: 824 WN--TGQIQQARKTDGSNRKSIRKDLD-YISDLKLYHRAKSMGSNQCGVDNGGCSHLCLP 880
G I++ K + ++ +R + + D+K+++R + G+N C V NGGC LCL
Sbjct: 2113 RTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLY 2172
Query: 881 TPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVANGECNDAYI-PLT 939
R CAC AH L +D +C E +LL++++ + I +++ +A + P
Sbjct: 2173 RG---RGQRACAC-AHGMLAEDGASCREYAGYLLYSERTILKSIHLSDERNLNAPVQPFE 2228
Query: 940 G---LKNVRAIEYD-------PVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGL 989
+KNV A+ +D ++++ D +I+++ GL
Sbjct: 2229 DPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIVENVGSVEGL 2288
Query: 990 SRPYHMVLDVLGRTMYWTCADRDSINATSIDN------NSSTGVIVRGDRMLPRHLAFHQ 1043
+ YH D T+YWT +I ++D T + + GD PR +
Sbjct: 2289 A--YHRGWD----TLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDH-PRAFVLDE 2341
Query: 1044 TKRYLIWNDVG--RGAIMRANVDGTGRVELARADNAT--ALALDQSAGTVYWAVSRQCDG 1099
+ + W + +IMRA + G + L D T LA+D A +Y++ D
Sbjct: 2342 CQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFS-DATLDK 2400
Query: 1100 QQDCE-DG 1106
+ CE DG
Sbjct: 2401 IERCEYDG 2408
Score = 397 bits (977), Expect = e-109
Identities = 288/970 (29%), Positives = 470/970 (48%), Gaps = 59/970 (6%)
Query: 10 ITTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGI 69
I+ D++ T +D+ R+ + WSD + + I+ N T G + +VS L G+
Sbjct: 1607 ISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGT--GVE-TVVSADLPNAHGL 1663
Query: 70 AIDWYTDKLYWTDGETNK--IEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWG 127
A+DW + L+WT +TNK I V + ++ + ++ + V P G ++WTD G
Sbjct: 1664 AVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVVQG-LEQPHGLVVHPLRGKLYWTD-G 1721
Query: 128 EIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKR 187
+ I A M+G + + ++ P G+ +D+ S +YW+ + ++ + +G
Sbjct: 1722 D--NISMANMDG---SNRTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGL 1776
Query: 188 KRV--VKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKV 245
+ + ++ L AL DKL+W D + + T A+G L S + +KV
Sbjct: 1777 EVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCS-KADGSGSVVLRNSTTLVMHMKV 1835
Query: 246 YDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQML 305
YDES Q+ PC NN CS LCL + + +C C G LR C L
Sbjct: 1836 YDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTR-SCMCTAGYSLRSGQQA-CEGVGSFL 1893
Query: 306 LVVAQRSTISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLD 365
L I I LD D + +P+ + +DF + + IYW D TIS+A+ D
Sbjct: 1894 LYSVHEG-IRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRD 1952
Query: 366 GS-DQSVVVRSSGVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRA 424
+ + VV G + IA+D ++ IYWTD D I VARL+GS+ V+I L PRA
Sbjct: 1953 QTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRA 2012
Query: 425 IALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDA 484
I +H G++FW++W + P+IER+ LDG+ RV+L++ ++WPN I++D + KLYW DA
Sbjct: 2013 ITVHPEKGYLFWTEWGQY-PRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDA 2071
Query: 485 RTHKIEVCNMDGTERKE--LHSNDI-IHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDR 541
RT KIE +++ E +E L SN++ + ++ R +K+ D
Sbjct: 2072 RTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDS 2131
Query: 542 QPVVEQMA-NMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRP-DDYICGCPLGLELTAD 599
P+ + + +K F G N CA NGGC LC R C C G+ L D
Sbjct: 2132 VPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGRGQRACACAHGM-LAED 2190
Query: 600 KKTCVEPEAFLVYSRKNIIGRLSIKNE--YNDAVIPIKD---LKEVSALAL-YVSGS--- 650
+C E +L+YS + I+ + + +E N V P +D +K V ALA Y +G+
Sbjct: 2191 GASCREYAGYLLYSERTILKSIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPG 2250
Query: 651 ---KLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVS 707
++++SD I + + +GS IVE +G VEGLA +YWT TT I
Sbjct: 2251 TPNRIFFSDIHFGNIQQINDDGSRRITIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRH 2310
Query: 708 RLD----GSSRR--AIIWQGLKKPKSIVLDPKKGYMYWSELGSK--SIKRAAMDGSSVSV 759
+D G+ R I G P++ VLD + M+W+ + SI RAA+ G++V
Sbjct: 2311 TVDQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLT 2370
Query: 760 FMEQVGRV-HALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPM-PYALALFND 817
+E+ R + LAID+ +Y++ +E +G+ R + + P+ P+ LA++ +
Sbjct: 2371 LIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGE 2430
Query: 818 SVYWGDWNTGQIQQARKTDGSNRKSIRKDLDY--ISDLKLYHRAKSMGSNQCGVDNGGCS 875
++W DW +Q+A K GSN K +R D+ + + + + S + C ++NGGC
Sbjct: 2431 HIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQ 2490
Query: 876 HLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVANGECNDAY 935
LCL T + C+C R+ +D++TC + + A ANGEC +
Sbjct: 2491 DLCLLTH---QGHVNCSCRGG-RILQDDLTCR-----AVNSSCRAQDEFECANGECINFS 2541
Query: 936 IPLTGLKNVR 945
+ G+ + +
Sbjct: 2542 LTCDGVPHCK 2551
Score = 377 bits (927), Expect = e-103
Identities = 252/876 (28%), Positives = 418/876 (47%), Gaps = 50/876 (5%)
Query: 253 ISAEDYPCKKNNAGCSHL-CLLSPDPPGYN--CACPTGVKLR-ENSSTTCYDSPQMLLVV 308
+ +++ C+ + HL C D ++ C+C G L + S D + ++
Sbjct: 1214 LGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFIIF 1273
Query: 309 AQRSTISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARL--DG 366
+ R I +I L D Y++ + L+ T+ +DF +YW D + I + +L +G
Sbjct: 1274 SNRHEIRRIDLHKGD---YSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNG 1330
Query: 367 ---SDQSVVVRSSGVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPR 423
S + V+ P+ +A+D ++ IYW + +D I VA+LDG+ ++ ++ PR
Sbjct: 1331 ALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPR 1390
Query: 424 AIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLT--WPNSIALDTVNNKLYW 481
AIAL G +FW+DW+ P+IE A++ G+GR + E + WPN + +D + ++ W
Sbjct: 1391 AIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEKRILW 1450
Query: 482 GDARTHKIEVCNMDGTERKE-LHSNDII-HIFGXXXXXXXXXXXXMQKRTLDRINKNTGL 539
DAR+ I DG+ E L ++ + H F + TL + NK TG
Sbjct: 1451 IDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGH 1510
Query: 540 DRQPVVEQMANMMGVKAFRLG-APLGWNPCADDNGG---CSHLC-FNRPDDYICGCPLGL 594
+ V ++ + P+ NPC + NGG CSHLC N C CP +
Sbjct: 1511 NVTVVQRTNTQPFDLQVYHPSRQPMAPNPC-EANGGQGPCSHLCLINYNRTVSCACPHLM 1569
Query: 595 ELTADKKTCVEPEAFLVYSRKNIIGRLSIKNEYNDAVI--PIKDLKEVSALALYVSGSKL 652
+L D TC E + FL+Y+R+ I + + Y + +I + D+ V+ L ++
Sbjct: 1570 KLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVLDYDAREQRV 1629
Query: 653 YWSDSKTKTINRCSVNGSAVEKIVEW-LGLVEGLAIDWSGQNIYWT--DTTTQRIEVSRL 709
YWSD +T+ I R +NG+ VE +V L GLA+DW +N++WT DT ++I V+RL
Sbjct: 1630 YWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARL 1689
Query: 710 DGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKSIKRAAMDGSS-VSVFMEQVGRVH 768
DGS + A++ QGL++P +V+ P +G +YW++ +I A MDGS+ +F Q G V
Sbjct: 1690 DGSFKNAVV-QGLEQPHGLVVHPLRGKLYWTD--GDNISMANMDGSNRTLLFSGQKGPV- 1745
Query: 769 ALAIDYERRAIYWAALDPPVVEFAFLNGTGRQ---TLADNIPMPYALALFNDSVYWGDWN 825
LAID+ +YW + + L+G+G + + + ALA+ D ++W D
Sbjct: 1746 GLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKLWWADQV 1805
Query: 826 TGQIQQARKTDGSNRKSIRKDLDYISDLKLYHRAKSM---GSNQCGVDNGGCSHLCLPTP 882
+ ++ K DGS +R + +K+Y + + G+N C V+NG CS LCLPT
Sbjct: 1806 SEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQLCLPTS 1865
Query: 883 GDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVANGECNDAYIPLTGLK 942
R+ C C A Y L C FLL++ + I + + +DA +P++G
Sbjct: 1866 ETTRS---CMCTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSGTS 1922
Query: 943 NVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGR 1002
I++ +YW+D +I R G+ R + +D +
Sbjct: 1923 LAVGIDFHAENDTIYWVDMGLSTISR-----AKRDQTWREDVVTNGIGRVEGIAVDWIAG 1977
Query: 1003 TMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGR-GAIMRA 1061
+YWT D I + N S V++ PR + H K YL W + G+ I R+
Sbjct: 1978 NIYWTDQGFDVIEVARL-NGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERS 2036
Query: 1062 NVDGTGRVELARADNA--TALALDQSAGTVYWAVSR 1095
+DGT RV L + +++D G +YW +R
Sbjct: 2037 RLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDAR 2072
Score = 260 bits (637), Expect = 2e-68
Identities = 201/717 (28%), Positives = 342/717 (47%), Gaps = 62/717 (8%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLR-ENSSTTCYDSP---QMLLVVAQRSTISKISLDSP 322
CS LC + + C C G L+ +N S + P +L++A I L
Sbjct: 160 CSQLCTNTDG--SFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGA 217
Query: 323 DFTPYTLPLKDLKRTLTVDFDPKTEYIYWA---DGLAKTISK-ARLDGS----DQSVVVR 374
+ T+ ++T +DF E + W D A+T K AR+ G D+ +
Sbjct: 218 QVS--TITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINI 275
Query: 375 SSGVP--DSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAG 432
S + + +AID L+ Y+ D + D I V +G ++ ELY+P+ IAL G
Sbjct: 276 SLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMG 335
Query: 433 WMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVC 492
+F++D+ + PK+ER ++DG R L+ K+ +P+ I LD V+ +YW DA IEV
Sbjct: 336 KVFFTDYGQI-PKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVV 394
Query: 493 NMDGTERKELHSNDII-HIFGXX------XXXXXXXXXXMQKRTLDRINKNTGLDRQPVV 545
+ +G R+ + +I H++G QK ++ R+N+ + Q V
Sbjct: 395 DYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVT 454
Query: 546 E-QMANMMGVKAFRLGAPLGWNPCADDN----GGCSHLCF--NRPDDYICGCPLGLELTA 598
+ + R + + C +D GGCS +C N C C G L +
Sbjct: 455 RVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGS 514
Query: 599 DKKTCVEP--EAFLVY--SRKNIIGRLSIKNEYNDA-VIPIKDLKEVSALALYVSGSKLY 653
D K+C +P E FLVY R II + + + D +IPI++L AL + +Y
Sbjct: 515 DGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIY 574
Query: 654 WSDSKTKTINRCSVNGSAVEKIV-EWLGLVEGLAIDWSGQNIYWTDTTTQR-IEVSRLD- 710
++D+ + I R ++G+ E I+ + + VEG+A+DW G N+YWTD ++ I V+RL+
Sbjct: 575 FADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEK 634
Query: 711 -GSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSK-------SIKRAAMDGSSVSVFM- 761
+R+ +I + P++IV+DP G+MYW++ ++RA MDGS +F+
Sbjct: 635 AAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVT 694
Query: 762 -EQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPMPYALAL--FNDS 818
+ V + L++D +YW +E LNGT R+ + + + +A L +
Sbjct: 695 SKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGNY 754
Query: 819 VYWGDWNTGQIQQARKTDGSNRKSI---RKDLDYISDLKLYH-RAKSMGSNQCGVDNGGC 874
++W ++ +G + + + G ++ R + I ++++Y + + +G+N+C V+NGGC
Sbjct: 755 LFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGGC 814
Query: 875 SHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVANGEC 931
S LCL TPG +CAC L+ D +TC ++ Q G AN C
Sbjct: 815 SSLCLATPG----SRQCACAEDQVLDADGVTCLANPSYVPPPQCQP-GEFACANSRC 866
Score = 255 bits (625), Expect = 6e-67
Identities = 176/636 (27%), Positives = 312/636 (49%), Gaps = 38/636 (5%)
Query: 9 RITTIAK-DLEQGTAVDFHYRKNLICW---SDQKPEL-IQC--MNYNETYTGEKFKIVSE 61
+++TI Q TA+DF Y +CW D + ++C M + + E +S
Sbjct: 218 QVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISL 277
Query: 62 GLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLM 121
L +AIDW T Y+ D ++I V + L E+ + IA+ P G +
Sbjct: 278 SLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKV 337
Query: 122 FWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVID 181
F+TD+G+IPK+ER M+G T+ +V I +P+GIT+D + L+YW DA L +++V+D
Sbjct: 338 FFTDYGQIPKVERCDMDGQNRTK--LVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVD 395
Query: 182 FNGEKRKRVVKGGLV-YPFALTFSNDKLYWTDWQNWSIY--TWDIAANGPKIKE--LIKS 236
+ G+ R+ +++G L+ + + LT + LY T+ N + T I N E ++
Sbjct: 396 YEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVTR 455
Query: 237 HPVPADIKVYDESRQIISAEDYPCKKNN----AGCSHLCLLSPDPPGYNCACPTGVKLRE 292
+ +Y + RQ + C+ + GCS +CLL+ C C +G L
Sbjct: 456 VDKGGALHIYHQRRQ-PRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGS 514
Query: 293 NSSTTCYDSPQMLLVV--AQRSTISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIY 350
+ + ++ LV + I + + + + +P+++L +DF +T +IY
Sbjct: 515 DGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIY 574
Query: 351 WADGLAKTISKARLDGSDQSVVVRSSGV--PDSIAIDPLSRKIYWTDP-VMDTINVARLD 407
+AD + I + ++DG+++ +++ G+ + +A+D + +YWTD TI+VARL+
Sbjct: 575 FADTTSYLIGRQKIDGTERETILK-DGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLE 633
Query: 408 GSYE--KVIIHTELYDPRAIALHLTAGWMFWSDWNE-----KKPKIERANLDGSGRVLLI 460
+ + K +I ++ PRAI + GWM+W+DW E ++ ++ERA +DGS R + +
Sbjct: 634 KAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFV 693
Query: 461 SEK-LTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSN-DIIHIFGXXXXXX 518
+ K + WPN ++LD +LYW DA +IE ++GT+RK ++ ++ H FG
Sbjct: 694 TSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGN 753
Query: 519 XXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFRL----GAPLGWNPCADDNGG 574
+ ++ R+ + G V + + R+ +G N C +NGG
Sbjct: 754 YLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGG 813
Query: 575 CSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFL 610
CS LC P C C L AD TC+ +++
Sbjct: 814 CSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYV 849
Score = 219 bits (534), Expect = 6e-56
Identities = 125/345 (36%), Positives = 191/345 (55%), Gaps = 19/345 (5%)
Query: 575 CSHLCFNRPDDYICGCPLGLELTA-DKKTC---VEPEAFLVYSRKNIIGRLSIKNEYNDA 630
CS C N Y C C G D +C + E FL+++ + + +L++ N
Sbjct: 2992 CSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGS-NYT 3050
Query: 631 VIPIKDLKEVSALALYVSGSKLYWSDSKTK--TINRCSVNGSAVEKIVEWLGLV--EGLA 686
++ + L AL +YW+D T+ I R +NGS V+ ++ GL +GLA
Sbjct: 3051 LLK-QGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQ-VLHRTGLSNPDGLA 3108
Query: 687 IDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS 746
+DW G N+YW D IEVS+L+G+ R ++ GL++P+++V+D + GY+YW++ G S
Sbjct: 3109 VDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHS 3168
Query: 747 -IKRAAMDGSSVSVFME-QVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQ-TLA 803
I R MDGSS SV ++ ++ + L +DY IYWA +EFA L+G+ R L+
Sbjct: 3169 LIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLS 3228
Query: 804 DNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYH--RAKS 861
+IP +AL LF D VYW DW T I +A KT G+N+ + L DL ++H R
Sbjct: 3229 QDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPD 3288
Query: 862 MGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
+ ++ C V+NGGCS+LCL +PG ++CACP ++ L D TC
Sbjct: 3289 VPNHPCKVNNGGCSNLCLLSPGG---GHKCACPTNFYLGSDGRTC 3330
Score = 206 bits (503), Expect = 4e-52
Identities = 111/346 (32%), Positives = 182/346 (52%), Gaps = 14/346 (4%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLRENSSTTC--YDSPQMLLVVAQRSTISKISLDSPDF 324
CS C+ + Y C C G R +C + L+ A R + K++LD +
Sbjct: 2992 CSQRCINTHG--SYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSN- 3048
Query: 325 TPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAK--TISKARLDGSDQSVVVRSS-GVPDS 381
YTL + L + +DFD + + IYW D + I + L+GS+ V+ R+ PD
Sbjct: 3049 --YTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDG 3106
Query: 382 IAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNE 441
+A+D + +YW D DTI V++L+G+Y V++ + L +PRA+ + + G+++W+DW +
Sbjct: 3107 LAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGD 3166
Query: 442 KKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKE 501
I R +DGS R +++ K+TWPN + LD V ++YW DAR IE ++DG+ R
Sbjct: 3167 HS-LIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHV 3225
Query: 502 LHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFR-LG 560
+ S DI HIF + ++++R +K TG ++ ++ + M + F L
Sbjct: 3226 VLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALR 3285
Query: 561 AP-LGWNPCADDNGGCSHLCFNRP-DDYICGCPLGLELTADKKTCV 604
P + +PC +NGGCS+LC P + C CP L +D +TCV
Sbjct: 3286 QPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCV 3331
Score = 197 bits (481), Expect = 2e-49
Identities = 109/289 (37%), Positives = 156/289 (53%), Gaps = 12/289 (4%)
Query: 11 TTIAKDLEQGTAVDFHYRKNLICWSDQKPE--LIQCMNYNETYTGEKFKIVSE-GLVTPT 67
T + + L A+DF YR+ +I W+D + +I+ M+ N G +++ GL P
Sbjct: 3050 TLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLN----GSNVQVLHRTGLSNPD 3105
Query: 68 GIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWG 127
G+A+DW LYW D + IEV + YR VL S + RA+ V ++G ++WTDWG
Sbjct: 3106 GLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWG 3165
Query: 128 EIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKR 187
+ I R GM+G ++R VIV I WPNG+T+DY IYW DA+ +++ +G R
Sbjct: 3166 DHSLIGRIGMDG--SSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNR 3223
Query: 188 KRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYD 247
V+ + + FALT D +YWTDW+ SI G LI + P D+ V+
Sbjct: 3224 HVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAH-KTTGTNKTLLISTLHRPMDLHVFH 3282
Query: 248 ESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSST 296
RQ ++PCK NN GCS+LCLLSP G+ CACPT L + T
Sbjct: 3283 ALRQ-PDVPNHPCKVNNGGCSNLCLLSPG-GGHKCACPTNFYLGSDGRT 3329
Score = 153 bits (370), Expect = 5e-36
Identities = 89/243 (36%), Positives = 122/243 (50%), Gaps = 12/243 (4%)
Query: 62 GLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLM 121
GL P GIAIDW +YWTD + IEV + + RK L +D AI V P G M
Sbjct: 3956 GLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTM 4015
Query: 122 FWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVID 181
+W+DWG PKIE A M+G R+ +V+DNI WP G+ VDY+N +YW DAKL + I
Sbjct: 4016 YWSDWGNHPKIETAAMDG--TLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIR 4073
Query: 182 FNGEKRKRVV--KGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPV 239
NG K GL +PF++ D +Y + N ++ + P + L
Sbjct: 4074 LNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLV-NLTGGLSH 4132
Query: 240 PADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCY 299
+D+ +Y + +Q PC + C LCLLSP P C CP G +L +N +
Sbjct: 4133 ASDVVLYHQHKQ--PEVTNPCDRKK--CEWLCLLSPSGP--VCTCPNGKRL-DNGTCVPV 4185
Query: 300 DSP 302
SP
Sbjct: 4186 PSP 4188
Score = 148 bits (358), Expect = 1e-34
Identities = 142/568 (25%), Positives = 238/568 (41%), Gaps = 59/568 (10%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTCV-------EPEAFLVYSRKNIIGRLSIKN 625
G CS LC N +ICGC G L D ++C P L+ + +NI+ +
Sbjct: 158 GTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATY-LSG 216
Query: 626 EYNDAVIPIKDLKEVSALALYVSGSKLYW---SDSKTKTINRCS----VNGSAVEKIVE- 677
+ P ++ +A+ + + W DS +T +C+ + G E +
Sbjct: 217 AQVSTITP-TSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINI 275
Query: 678 --WLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKG 735
L VE +AIDW N Y+ D RI V +G + ++ L PK I LDP G
Sbjct: 276 SLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMG 335
Query: 736 YMYWSELGS-KSIKRAAMDGSSVSVFME-QVGRVHALAIDYERRAIYWAALDPPVVEFAF 793
+++++ G ++R MDG + + ++ ++ H + +D R +YWA +E
Sbjct: 336 KVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVD 395
Query: 794 LNGTGRQTLADNIPMP--YALALFNDSVYWGDWNTGQIQQARKTDGSNR-----KSIRKD 846
G GRQT+ I + Y L +F + +Y + + QQ NR +
Sbjct: 396 YEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVTR 455
Query: 847 LDYISDLKLYH--RAKSMGSNQCGVDN----GGCSHLC-LPTPGDVRTDYRCACPAHYRL 899
+D L +YH R + S+ C D GGCS +C L RT C C + + L
Sbjct: 456 VDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKART---CRCRSGFSL 512
Query: 900 NKDNITCSEPEE--FLLFAQ-KNAVGRIMVANGECNDAY-IPLTGLKNVRAIEYDPVEKQ 955
D +C +PE FL++ + + + R M + D + IP+ L N RA+++
Sbjct: 513 GSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGF 572
Query: 956 LYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWT-CADRDSI 1014
+Y+ D S+ I R I G+ + +D +G +YWT + +I
Sbjct: 573 IYFADTTSYLIGRQKID-----GTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTI 627
Query: 1015 NATSIDNNSST-GVIVRGDRMLPRHLAFHQTKRYLIW-------NDVGRGAIMRANVDGT 1066
+ ++ + T ++ G PR + ++ W D RG + RA +DG+
Sbjct: 628 SVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGS 687
Query: 1067 GRVELARADNA---TALALDQSAGTVYW 1091
R + L+LD AG +YW
Sbjct: 688 HRDIFVTSKTVLWPNGLSLDIPAGRLYW 715
Score = 135 bits (326), Expect = 1e-30
Identities = 102/360 (28%), Positives = 169/360 (46%), Gaps = 35/360 (9%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVY-SRKNIIGRLSIKNEYN--D 629
G CS LC N ++C C T + E ++Y + N I L + ++ +
Sbjct: 3832 GTCSQLCNNTKGGHLCSCARNFMKTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYE 3891
Query: 630 AVIPIKDLKEVSALALYVSGSKLYWSDSKTKTIN----------------RCSVNGSAVE 673
+ + A+ ++V ++YW++ T TI+ R ++
Sbjct: 3892 QAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTH 3951
Query: 674 KIVEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPK 733
+ L + G+AIDW N+YWTD+ IEV+++ G +R+ +I + +P +IV+DP
Sbjct: 3952 LNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPL 4011
Query: 734 KGYMYWSELGS-KSIKRAAMDGS-SVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEF 791
+G MYWS+ G+ I+ AAMDG+ ++ + + LA+DY +YWA V+
Sbjct: 4012 RGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGS 4071
Query: 792 AFLNGTGRQTLADN---IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLD 848
LNGT AD+ + P+++ +F D +Y + ++ + K S ++ L
Sbjct: 4072 IRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLS 4131
Query: 849 YISDLKLYHRAKSMG-SNQCGVDNGGCSHLCLPTP-GDVRTDYRCACPAHYRLNKDNITC 906
+ SD+ LYH+ K +N C D C LCL +P G V C CP RL DN TC
Sbjct: 4132 HASDVVLYHQHKQPEVTNPC--DRKKCEWLCLLSPSGPV-----CTCPNGKRL--DNGTC 4182
Score = 111 bits (268), Expect = 1e-23
Identities = 96/359 (26%), Positives = 151/359 (42%), Gaps = 30/359 (8%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDSPDFTP 326
CS LC + G+ C+C ++ +++ S +L +A + I + P +
Sbjct: 3834 CSQLC--NNTKGGHLCSCARNF-MKTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPH-SA 3889
Query: 327 YTLPLK--DLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGS-------------DQSV 371
Y + + R +D K +YW + TIS L + D+ V
Sbjct: 3890 YEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGV 3949
Query: 372 V-VRSSGV--PDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALH 428
+ SG+ P IAID ++ +YWTD D I VA++ G K +I + +P AI +
Sbjct: 3950 THLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVD 4009
Query: 429 LTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHK 488
G M+WSDW PKIE A +DG+ R L+ + + WP +A+D N +LYW DA+
Sbjct: 4010 PLRGTMYWSDWG-NHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSV 4068
Query: 489 IEVCNMDGTER--KELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVE 546
I ++GT+ + H F + +I+K +
Sbjct: 4069 IGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTG 4128
Query: 547 QMANMMGVKAF-RLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
+++ V + + P NPC D C LC P +C CP G L D TCV
Sbjct: 4129 GLSHASDVVLYHQHKQPEVTNPC--DRKKCEWLCLLSPSGPVCTCPNGKRL--DNGTCV 4183
Score = 93.9 bits (223), Expect = 3e-18
Identities = 81/254 (31%), Positives = 130/254 (51%), Gaps = 21/254 (8%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDS-PQMLLVVAQRSTISKIS 318
C NN GCSH C ++P G C+CP G++L ++ T S L +Q+ +K S
Sbjct: 1185 CSLNNGGCSHNCSVAPG-EGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFS 1243
Query: 319 LDSPDFTPYTL-PLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSG 377
+ + + L P + R+L DP +I +++ I + L D SV+V G
Sbjct: 1244 VKCSCYEGWVLEPDGESCRSL----DPFKPFIIFSN--RHEIRRIDLHKGDYSVLV--PG 1295
Query: 378 VPDSIAID-PLSRK-IYWTDPVMDTINVARL--DGSYE--KVIIHTELYDPRAIALHLTA 431
+ ++IA+D LS+ +YWTD V D I +L +G+ +V+I L P +A+ A
Sbjct: 1296 LRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIA 1355
Query: 432 GWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYW--GDARTHKI 489
G ++W + N +IE A LDG+ R L++ + P +IALD + L+W DA +I
Sbjct: 1356 GNIYWVESN--LDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRI 1413
Query: 490 EVCNMDGTERKELH 503
E +M G R+ +H
Sbjct: 1414 EAASMSGAGRRTVH 1427
Score = 87.0 bits (206), Expect = 4e-16
Identities = 79/302 (26%), Positives = 135/302 (44%), Gaps = 25/302 (8%)
Query: 568 CADDNGGCSHLCFNRPDD-YICGCPLGLELTADKKTC-VEP--EAFLVYSRKNIIGRLSI 623
C+ +NGGCSH C P + +C CPLG+EL D TC ++ L S+K + S+
Sbjct: 1185 CSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSV 1244
Query: 624 KNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVE 683
K + + D + +L + K + S I R ++ +V GL
Sbjct: 1245 KCSCYEGWVLEPDGESCRSLDPF----KPFIIFSNRHEIRRIDLHKGDYSVLVP--GLRN 1298
Query: 684 GLAIDW--SGQNIYWTDTTTQRIEVSRL--DG--SSRRAIIWQGLKKPKSIVLDPKKGYM 737
+A+D+ S +YWTD +I +L +G +S +I GL P+ + +D G +
Sbjct: 1299 TIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNI 1358
Query: 738 YWSELGSKSIKRAAMDGS-SVSVFMEQVGRVHALAIDYERRAIYWAALDP--PVVEFAFL 794
YW E I+ A +DG+ ++ + A+A+D ++W D P +E A +
Sbjct: 1359 YWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASM 1418
Query: 795 NGTGRQTL-----ADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDY 849
+G GR+T+ + P + + W D + I AR DGS + + ++
Sbjct: 1419 SGAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSAR-YDGSGHMEVLRGHEF 1477
Query: 850 IS 851
+S
Sbjct: 1478 LS 1479
Score = 75.4 bits (177), Expect = 1e-12
Identities = 63/232 (27%), Positives = 102/232 (43%), Gaps = 22/232 (9%)
Query: 874 CSHLCLPTPGDVRTDYRCACPAHYR-LNKDNITC---SEPEEFLLFAQKNAVGRIMVANG 929
CS C+ T G Y+C C Y D +C ++ E FL+FA + + ++ N
Sbjct: 2992 CSQRCINTHGS----YKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKL---NL 3044
Query: 930 ECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHS--IRRVPISYXXXXXXXXXXXXXX 987
+ ++ + GL N A+++D E+ +YW D + IRR+ ++
Sbjct: 3045 DGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLN-----GSNVQVLHRT 3099
Query: 988 GLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRY 1047
GLS P + +D +G +YW RD+I + + N + V+V PR L Y
Sbjct: 3100 GLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKL-NGAYRTVLVSSGLREPRALVVDVQNGY 3158
Query: 1048 LIWNDVG-RGAIMRANVDGTGRVEL--ARADNATALALDQSAGTVYWAVSRQ 1096
L W D G I R +DG+ R + + L LD +YWA +R+
Sbjct: 3159 LYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADARE 3210
Score = 65.3 bits (152), Expect = 1e-09
Identities = 62/235 (26%), Positives = 97/235 (41%), Gaps = 22/235 (9%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC---SEPEEFLLFAQKNAV 921
+QC ++NGGCSH C PG+ C+CP L DN TC S + L +QK
Sbjct: 1183 DQCSLNNGGCSHNCSVAPGE---GIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQ 1239
Query: 922 GRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXX 981
+ V C + ++ ++ R++ DP + + + + H IRR+ +
Sbjct: 1240 NKFSV-KCSCYEGWVLEPDGESCRSL--DPFKPFIIF--SNRHEIRRIDLHKGDYSVLVP 1294
Query: 982 XXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSI-NATSIDNNSSTG--VIVRGDRMLPRH 1038
L +H+ L YWT D I +DN + T V+++ P
Sbjct: 1295 GLRNTIALD--FHLSQSAL----YWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEG 1348
Query: 1039 LAFHQTKRYLIWNDVGRGAIMRANVDGTGRVELARAD--NATALALDQSAGTVYW 1091
LA + W + I A +DGT R L D + A+ALD G ++W
Sbjct: 1349 LAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFW 1403
Score = 64.9 bits (151), Expect = 2e-09
Identities = 48/186 (25%), Positives = 82/186 (44%), Gaps = 11/186 (5%)
Query: 35 SDQKPELIQCMNY---NETYTGEKFKIVSEGLVTPTGIAIDWYTDKLYWTDGET--NKIE 89
+D++P LI Y G + ++ +GL + D+ +YWTD T + I
Sbjct: 3025 TDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIR 3084
Query: 90 VISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERAGMNGDPATRKVIVR 149
+ + +VL + + +AV G ++W D G IE + +NG A R V+V
Sbjct: 3085 RMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGR-DTIEVSKLNG--AYRTVLVS 3141
Query: 150 DNIFWPNGITVDYNNSLIYWVD-AKLQFVDVIDFNGEKRKRVVKGGLVYPFALT--FSND 206
+ P + VD N +YW D + I +G R +V + +P LT + +
Sbjct: 3142 SGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTE 3201
Query: 207 KLYWTD 212
++YW D
Sbjct: 3202 RIYWAD 3207
Score = 56.4 bits (130), Expect = 6e-07
Identities = 60/252 (23%), Positives = 92/252 (36%), Gaps = 18/252 (7%)
Query: 933 DAYIPLTGLKNVRAIEYDPVEKQLYWMD-DDSH-SIRRVPISYXXXXXXXXXXXXXXGLS 990
+ I ++G + RA D + ++W + ++ H SI R +S +
Sbjct: 2323 ETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALS-----GANVLTLIEKDIR 2377
Query: 991 RPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIW 1050
P + +D +Y++ A D I D S VI++ + + P LA + ++ W
Sbjct: 2378 TPNGLAIDHRAEKLYFSDATLDKIERCEYDG-SHRYVILKSEPVHPFGLAVYG--EHIFW 2434
Query: 1051 NDVGRGAIMRANVDGTGRVELARADNATALALDQSAGTVYWAVSRQCDGQQDCE--DGRD 1108
D R A+ RAN ++L R D Q G + A C +G
Sbjct: 2435 TDWVRRAVQRANKHVGSNMKLLRVDIP-----QQPMGIIAVANDTNSCELSPCRINNGGC 2489
Query: 1109 EAECGACG-GDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQ 1167
+ C G V C+ D F C G CI CDG P
Sbjct: 2490 QDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFECANGECINFSLTCDGVPH 2549
Query: 1168 CADGSDEAPAAC 1179
C D SDE P+ C
Sbjct: 2550 CKDKSDEKPSYC 2561
Score = 52.0 bits (119), Expect = 1e-05
Identities = 49/170 (28%), Positives = 60/170 (35%), Gaps = 8/170 (4%)
Query: 923 RIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXX 982
R M NG N + TGL N + D V LYW D R I
Sbjct: 3084 RRMHLNGS-NVQVLHRTGLSNPDGLAVDWVGGNLYWCDKG-----RDTIEVSKLNGAYRT 3137
Query: 983 XXXXXGLSRPYHMVLDVLGRTMYWT-CADRDSINATSIDNNSSTGVIVRGDRMLPRHLAF 1041
GL P +V+DV +YWT D I +D SS VIV P L
Sbjct: 3138 VLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDG-SSRSVIVDTKITWPNGLTL 3196
Query: 1042 HQTKRYLIWNDVGRGAIMRANVDGTGRVELARADNATALALDQSAGTVYW 1091
+ W D I A++DG+ R + D AL VYW
Sbjct: 3197 DYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYW 3246
Score = 51.6 bits (118), Expect = 2e-05
Identities = 63/253 (24%), Positives = 89/253 (35%), Gaps = 22/253 (8%)
Query: 945 RAIEYDPVEKQLYWMD--DDSHSIRRVPISYX-XXXXXXXXXXXXXGLSRPYHMVLDVLG 1001
RAI DP+ +YW D +D RR + + P + LD+
Sbjct: 651 RAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPA 710
Query: 1002 RTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGAIMRA 1061
+YW A D I T + N + ++ G + H YL W + G++ R
Sbjct: 711 GRLYWVDAFYDRIE-TILLNGTDRKIVYEGPELNHAFGLCHHGN-YLFWTEYRSGSVYRL 768
Query: 1062 N--VDGTG-RVELARADNATALALDQSAGTVYWAVSRQCDGQQDCE--DGRDEAECGACG 1116
V G V L R++ + +Y A +Q G C +G + C A
Sbjct: 769 ERGVGGAPPTVTLLRSERPPIFEI-----RMYDAQQQQV-GTNKCRVNNGGCSSLCLATP 822
Query: 1117 GDVRCADGTXXXXXXXXXXXXXXXXXX-----XXDAFRCDEGLCIAARFVCDGRPQCADG 1171
G +CA F C CI R+ CDG C D
Sbjct: 823 GSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDN 882
Query: 1172 SDEAPAACAYGHT 1184
SDEAPA C + HT
Sbjct: 883 SDEAPALC-HQHT 894
Score = 50.8 bits (116), Expect = 3e-05
Identities = 33/100 (33%), Positives = 38/100 (38%), Gaps = 16/100 (16%)
Query: 1096 QCDGQQDCEDGRDEAECGA---------CGGDVRC------ADGTXXXXXXXXXXXXXXX 1140
+C+GQ +C DG DE +C C RC D
Sbjct: 3432 RCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQ 3491
Query: 1141 XXXXXDAFRC-DEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
D FRC D G CI AR+ CDG C DGSDE C
Sbjct: 3492 MTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEEC 3531
Score = 48.4 bits (110), Expect = 2e-04
Identities = 39/114 (34%), Positives = 42/114 (36%), Gaps = 30/114 (26%)
Query: 1093 VSRQ--CDGQQDCEDGRDEAE------CGA-----------------CGGDVRCADGTXX 1127
+S+Q CDG DC DG DEA CG C GD CADG
Sbjct: 2747 ISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADE 2806
Query: 1128 XXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAACAY 1181
F C CI FVCD CADGSDE+P C Y
Sbjct: 2807 SIAAGCLYNSTCDDRE----FMCQNRQCIPKHFVCDHDRDCADGSDESP-ECEY 2855
Score = 48.0 bits (109), Expect = 2e-04
Identities = 28/83 (33%), Positives = 32/83 (38%), Gaps = 2/83 (2%)
Query: 1094 SRQCDGQQ-DCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCD- 1151
S C Q C GR E C GD C D + D F+C
Sbjct: 1012 SHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRL 1071
Query: 1152 EGLCIAARFVCDGRPQCADGSDE 1174
+GLCI R+ CDG C D SDE
Sbjct: 1072 DGLCIPLRWRCDGDTDCMDSSDE 1094
Score = 48.0 bits (109), Expect = 2e-04
Identities = 30/99 (30%), Positives = 35/99 (35%), Gaps = 14/99 (14%)
Query: 1096 QCDGQQDCEDGRDEAECGA-CGGDV-------------RCADGTXXXXXXXXXXXXXXXX 1141
+CDG DC DG DE +C C D RC
Sbjct: 3593 KCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVR 3652
Query: 1142 XXXXDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAACA 1180
D F+C+ LC + CDG C D SDE P CA
Sbjct: 3653 TCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECA 3691
Score = 47.2 bits (107), Expect = 4e-04
Identities = 32/107 (29%), Positives = 43/107 (40%), Gaps = 15/107 (14%)
Query: 1093 VSRQCDGQQDCEDGRDEAECGACGGDV-------RC------ADGTXXXXXXXXXXXXXX 1139
+S CD + DCE G DE C + RC DG+
Sbjct: 2711 MSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCE 2770
Query: 1140 XXXXXXDAFRCD-EGLCIAARFVCDGRPQCADGSDEAPAA-CAYGHT 1184
+F C +C+ R++CDG CADG+DE+ AA C Y T
Sbjct: 2771 GKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNST 2817
Score = 43.6 bits (98), Expect = 0.004
Identities = 32/95 (33%), Positives = 36/95 (37%), Gaps = 17/95 (17%)
Query: 1096 QCDGQQDCEDGRDEA--ECGA---------CGGDVRCADGTXXXXXXXXXXXXXXXXXXX 1144
+CDG+ DC DG DE EC C + RC G
Sbjct: 3513 KCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNN-RCVPGRWQCDYDNDCGDNSDEESCT 3571
Query: 1145 -----XDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
F C G CIA R+ CDG CADGSDE
Sbjct: 3572 PRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDE 3606
Score = 43.2 bits (97), Expect = 0.006
Identities = 25/86 (29%), Positives = 35/86 (40%), Gaps = 7/86 (8%)
Query: 1096 QCD-GQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGL 1154
QC G+ C + R E C GD C D + D F+C+
Sbjct: 853 QCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPS------DRFKCENNR 906
Query: 1155 CIAARFVCDGRPQCADGSDEAPAACA 1180
CI R++CDG C + DE+ A C+
Sbjct: 907 CIPNRWLCDGDNDCGNSEDESNATCS 932
Score = 41.9 bits (94), Expect = 0.013
Identities = 18/44 (40%), Positives = 21/44 (47%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAACAYGHTDQVNGIH 1191
F+C+ G CI + CDG C D SDE A C T G H
Sbjct: 1020 FKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCH 1063
Score = 40.7 bits (91), Expect = 0.031
Identities = 33/101 (32%), Positives = 37/101 (36%), Gaps = 23/101 (22%)
Query: 1097 CDGQQDCEDGRDEAECG--ACG-GDVRCADGTXXXXXX---------XXXXXXXXXXXXX 1144
C+G DC DG DE C ACG G+ RC DGT
Sbjct: 2585 CNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDC 2644
Query: 1145 XDAFR----------CDE-GLCIAARFVCDGRPQCADGSDE 1174
FR C+ LC A +VCDG C D SDE
Sbjct: 2645 SSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDE 2685
Score = 39.5 bits (88), Expect = 0.071
Identities = 26/119 (21%), Positives = 47/119 (39%), Gaps = 1/119 (0%)
Query: 9 RITTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGL-VTPT 67
R T +A D+E A+ R ++ W+D L + + + G + G P
Sbjct: 1378 RTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPN 1437
Query: 68 GIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDW 126
G+ +D+ ++ W D ++ I + L+ AV G ++WTDW
Sbjct: 1438 GLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDW 1496
Score = 39.1 bits (87), Expect = 0.094
Identities = 17/33 (51%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 1148 FRC-DEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F C D+ CI+ + CDG C DGSDEAP C
Sbjct: 32 FACRDQITCISKGWRCDGERDCPDGSDEAPEIC 64
Score = 38.7 bits (86), Expect = 0.12
Identities = 29/100 (29%), Positives = 38/100 (38%), Gaps = 22/100 (22%)
Query: 1097 CDGQQDCEDGRDEA-ECG--ACG-GDVRCADGTXXXXXXXXXXXXXXXXXXXXDA----- 1147
CD +DC DG DE+ EC CG + RCA+G +A
Sbjct: 2837 CDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPH 2896
Query: 1148 -------------FRCDEGLCIAARFVCDGRPQCADGSDE 1174
F C G C+A +C+G+ C D SDE
Sbjct: 2897 CTSPEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDE 2936
Score = 38.7 bits (86), Expect = 0.12
Identities = 14/28 (50%), Positives = 17/28 (60%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEA 1175
F+C G+C F+CDG C D SDEA
Sbjct: 3379 FQCSTGICTNPAFICDGDNDCQDNSDEA 3406
Score = 38.3 bits (85), Expect = 0.16
Identities = 33/139 (23%), Positives = 53/139 (38%), Gaps = 7/139 (5%)
Query: 935 YIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYH 994
++ ++GLK R I D V +YW D R I + P+
Sbjct: 3951 HLNISGLKMPRGIAIDWVAGNVYWTDSG-----RDVIEVAQMKGENRKTLISGMIDEPHA 4005
Query: 995 MVLDVLGRTMYWT-CADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDV 1053
+V+D L TMYW+ + I ++D + +V+ + P LA L W D
Sbjct: 4006 IVVDPLRGTMYWSDWGNHPKIETAAMD-GTLRETLVQDNIQWPTGLAVDYHNERLYWADA 4064
Query: 1054 GRGAIMRANVDGTGRVELA 1072
I ++GT + A
Sbjct: 4065 KLSVIGSIRLNGTDPIVAA 4083
Score = 37.9 bits (84), Expect = 0.22
Identities = 16/30 (53%), Positives = 20/30 (66%), Gaps = 1/30 (3%)
Query: 1148 FRCDEGLCIAAR-FVCDGRPQCADGSDEAP 1176
FRC G C+++R + CDG C D SDEAP
Sbjct: 2863 FRCANGRCLSSRQWECDGENDCHDQSDEAP 2892
Score = 36.7 bits (81), Expect = 0.50
Identities = 25/82 (30%), Positives = 29/82 (35%), Gaps = 6/82 (7%)
Query: 1107 RDEAEC--GACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFR-CDEGLCIAARFVCD 1163
+DE EC G C DG FR C G C++ C+
Sbjct: 2527 QDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCN 2586
Query: 1164 GRPQCADGSDEAP---AACAYG 1182
G C DGSDE P AC G
Sbjct: 2587 GADDCGDGSDEIPCNKTACGVG 2608
Score = 35.9 bits (79), Expect = 0.87
Identities = 12/36 (33%), Positives = 24/36 (66%)
Query: 58 IVSEGLVTPTGIAIDWYTDKLYWTDGETNKIEVISI 93
+V + + PTG+A+D++ ++LYW D + + I I +
Sbjct: 4039 LVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRL 4074
Score = 35.5 bits (78), Expect = 1.2
Identities = 16/34 (47%), Positives = 19/34 (55%), Gaps = 1/34 (2%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAACAY 1181
F C G CI + CD C D SDE+ A+CAY
Sbjct: 941 FSCASGRCIPISWTCDLDDDCGDRSDES-ASCAY 973
Score = 35.1 bits (77), Expect = 1.5
Identities = 19/60 (31%), Positives = 27/60 (45%), Gaps = 2/60 (3%)
Query: 1035 LPRHLAFHQTKRYLIWNDVGRGAIMRANVDGTGRVELARA--DNATALALDQSAGTVYWA 1092
+PR +A + W D GR I A + G R L D A+ +D GT+YW+
Sbjct: 3959 MPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWS 4018
Score = 34.7 bits (76), Expect = 2.0
Identities = 32/113 (28%), Positives = 36/113 (31%), Gaps = 20/113 (17%)
Query: 1097 CDGQQDCEDGRDE-AECG--ACGGD-VRCADGTXXXXXXXXXXXXXXXXXXXXDA----- 1147
CD DC DG DE A C CG D RC D +
Sbjct: 3473 CDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECD 3532
Query: 1148 --------FRCDEGLCIAARFVCDGRPQCADGSDE---APAACAYGHTDQVNG 1189
FRC C+ R+ CD C D SDE P C+ NG
Sbjct: 3533 ERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANG 3585
Score = 33.5 bits (73), Expect = 4.7
Identities = 11/20 (55%), Positives = 14/20 (70%)
Query: 1093 VSRQCDGQQDCEDGRDEAEC 1112
+ RQCDG +C DG DE +C
Sbjct: 3712 IGRQCDGTDNCGDGTDEEDC 3731
Score = 33.1 bits (72), Expect = 6.2
Identities = 13/28 (46%), Positives = 15/28 (53%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEA 1175
F C+ G CI + CD C D SDEA
Sbjct: 982 FTCNNGRCININWRCDNDNDCGDNSDEA 1009
Score = 33.1 bits (72), Expect = 6.2
Identities = 33/173 (19%), Positives = 60/173 (34%), Gaps = 4/173 (2%)
Query: 922 GRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXX-XXXXX 980
G I N + + + + +V + Y LYW + +I R +
Sbjct: 2263 GNIQQINDDGSRRITIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFER 2322
Query: 981 XXXXXXXGLSRPYHMVLDVLGRTMYWTCADRD--SINATSIDNNSSTGVIVRGDRMLPRH 1038
G P VLD M+WT + SI ++ + ++ ++ D P
Sbjct: 2323 ETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAAL-SGANVLTLIEKDIRTPNG 2381
Query: 1039 LAFHQTKRYLIWNDVGRGAIMRANVDGTGRVELARADNATALALDQSAGTVYW 1091
LA L ++D I R DG+ R + +++ L ++W
Sbjct: 2382 LAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFW 2434
>U33837-1|AAB41649.1| 4655|Homo sapiens gp330 precursor protein.
Length = 4655
Score = 439 bits (1081), Expect = e-122
Identities = 322/1138 (28%), Positives = 545/1138 (47%), Gaps = 72/1138 (6%)
Query: 4 TSRLTRITTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGL 63
TS++ I ++ ++ AVDF I WSD Q ++ G ++V +
Sbjct: 1452 TSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDAT----QGKTWSAFQNGTDRRVVFDSS 1507
Query: 64 VTPTG-IAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPE--DGL 120
+ T IAIDW LYWTD IEV I +R VL + R +A+ P + L
Sbjct: 1508 IILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHL 1567
Query: 121 MFWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVI 180
+FW+DWG P+IERA M+G + R VIV+D IFWP G+T+DY N L+Y++D+ L ++D
Sbjct: 1568 LFWSDWGHHPRIERASMDG--SMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFC 1625
Query: 181 DFNGEKRKRVVKGGLV--YPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHP 238
D+NG R++V+ L+ +P+ALT D +YWTD + + +G ++ +
Sbjct: 1626 DYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRAN-KWHGGNQSVVMYNIQ 1684
Query: 239 VPADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPG-YNCACPTGVKLRENSSTT 297
P I S+Q S PC + CSHLCLLS P Y+C CP+G L +
Sbjct: 1685 WPLGIVAVHPSKQPNSVN--PCAFSR--CSHLCLLSSQGPHFYSCVCPSGWSLSPD-LLN 1739
Query: 298 CYDSPQMLLVVAQRSTISKISLD-SPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLA 356
C Q L+ ++ I ISL+ +P+ ++ L V+FD +YIYW +
Sbjct: 1740 CLRDDQPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPG 1799
Query: 357 KTISKARLDGSDQSVVVRSSGVPDS--IAIDPLSRKIYWTDPVMDTINVARLDGS--YEK 412
+ I + + DG++++V S V S +A+D +SR +Y T+P +I V L G Y K
Sbjct: 1800 E-IHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRK 1858
Query: 413 VIIHTE-----LYDPRAIALHLTAGWMFWSDWNEKK---PKIERANLDGSGRVLLISEKL 464
+I + + P I + G ++WSD KI AN+DG+ L + L
Sbjct: 1859 TLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNL 1918
Query: 465 TWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXXXXXXXXXX 524
+ LD KLYW IE N+DGT+R L + + H +G
Sbjct: 1919 EHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMIL-VHQLSHPWGIAVHDSFLYYTD 1977
Query: 525 MQKRTLDRINKNTGLDRQPVVEQMANMMGVKAF-RLGAPLGWNPCADDNGGCSHLCFNRP 583
Q ++R++K TG ++ + + + N+ G++ + R A N C+++ C +C P
Sbjct: 1978 EQYEVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNNMNACQQICLPVP 2037
Query: 584 DD-YICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGRLSIK-NEYNDAVIPIKDL-KEV 640
+ C C G +L D ++C +F+V S + I S++ +++++ ++P+ +
Sbjct: 2038 GGLFSCACATGFKLNPDNRSCSPYNSFIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNA 2097
Query: 641 SALALYVSGSKLYWSD-----SKTKTINRCSVNGSAVEKIV-EWLGL--VEGLAIDWSGQ 692
+ + VS +YW D + I R +GS++ IV +G V G+A+DW
Sbjct: 2098 LHVDVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAG 2157
Query: 693 NIYWTDTTTQR--IEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSK-SIKR 749
N+Y+T+ IEV R++ + RR ++ + P+ IV+DPK Y++W++ G + I+R
Sbjct: 2158 NLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQRPKIER 2217
Query: 750 AAMDGSSVSVFM-EQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTL--ADNI 806
+ +D ++ +V + E + LA+D +YW ++ +NG + +
Sbjct: 2218 SFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRY 2277
Query: 807 PMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKS--IRKDLDYISDLKLYHR------ 858
P PY + +F +S+ W D N +I QA K + IR +++++ D+ ++ +
Sbjct: 2278 PTPYGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRS 2337
Query: 859 AKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS-EPEEFLLFAQ 917
+ +N C +NGGCSHLC PG + T +C C A L D C+ E FL+FA
Sbjct: 2338 PAEVNNNPCLENNGGCSHLCFALPG-LHTP-KCDC-AFGTLQSDGKNCAISTENFLIFAL 2394
Query: 918 KNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXX 977
N++ + + + + + + V +++YD V ++Y+ + + + + ISY
Sbjct: 2395 SNSLRSLHLDPENHSPPFQTINVERTVMSLDYDSVSDRIYFTQNLASGVGQ--ISYATLS 2452
Query: 978 XXXXX-XXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLP 1036
G+ + D + R +Y++ IN+ + D ++ T VI R + P
Sbjct: 2453 SGIHTPTVIASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNRT-VIARVPK--P 2509
Query: 1037 RHLAFHQTKRYLIWNDVGRGA-IMRANVDGTGRVELARAD--NATALALDQSAGTVYW 1091
R + + YL W D A I RA + G RV + + + L LD +YW
Sbjct: 2510 RAIVLDPCQGYLYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYW 2567
Score = 362 bits (890), Expect = 5e-99
Identities = 252/853 (29%), Positives = 424/853 (49%), Gaps = 54/853 (6%)
Query: 280 YNCACPTGVKLRENSSTTC--YDSPQMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRT 337
+ C+C TG L E+ TC S +LL+VA ++ I S+ S Y+L +++
Sbjct: 1411 FRCSCDTGYML-ESDGRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSL-VENGSYI 1468
Query: 338 LTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGV-PDSIAIDPLSRKIYWTDP 396
+ VDFD + I+W+D A +G+D+ VV SS + ++IAID + R +YWTD
Sbjct: 1469 VAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDY 1528
Query: 397 VMDTINVARLDGSYEKVIIHTELYDPRAIAL--HLTAGWMFWSDWNEKKPKIERANLDGS 454
++TI V+++DGS+ V+I L +PR +AL + +FWSDW P+IERA++DGS
Sbjct: 1529 ALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGH-HPRIERASMDGS 1587
Query: 455 GRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDII--HIFG 512
R +++ +K+ WP + +D N LY+ D+ ++ C+ +G R+++ ++D+I H +
Sbjct: 1588 MRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYA 1647
Query: 513 XXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFRLG-APLGWNPCADD 571
R + R NK G ++ V+ + +G+ A P NPCA
Sbjct: 1648 LTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFS 1707
Query: 572 NGGCSHLCF---NRPDDYICGCPLGLELTADKKTCV-EPEAFLVYSRKNIIGRLSIKNEY 627
CSHLC P Y C CP G L+ D C+ + + FL+ R++II +S+ E
Sbjct: 1708 R--CSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNCLRDDQPFLITVRQHIIFGISLNPEV 1765
Query: 628 --NDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGS--AVEKIVEWLGLVE 683
NDA++PI ++ + + +YW ++ + I+R +G+ V + +G
Sbjct: 1766 KSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPGE-IHRVKTDGTNRTVFASISMVGPSM 1824
Query: 684 GLAIDWSGQNIYWTDTTTQRIEVSRLDGS--SRRAIIWQ-----GLKKPKSIVLDPKKGY 736
LA+DW +N+Y T+ TQ IEV L G R+ +I G+ P I +DP +G
Sbjct: 1825 NLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGK 1884
Query: 737 MYWSELGSKS-----IKRAAMDGSSV-SVFMEQVGRVHALAIDYERRAIYWAALDPPVVE 790
+YWS+ G+ S I A MDG+SV ++F + + + +D E + +YWA V+E
Sbjct: 1885 LYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIE 1944
Query: 791 FAFLNGTGRQTLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYI 850
++GT R L + P+ +A+ + +Y+ D I++ K G+N+ +R ++ +
Sbjct: 1945 RGNVDGTDRMILVHQLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNL 2004
Query: 851 SDLKLYHRAKSM-GSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEP 909
L++YHR + SN C + C +CLP PG + + CAC ++LN DN +CS
Sbjct: 2005 RGLQVYHRRNAAESSNGCSNNMNACQQICLPVPGGL---FSCACATGFKLNPDNRSCSPY 2061
Query: 910 EEFLLFAQKNAVGRIMVANGECNDAYIPLTGL-KNVRAIEYDPVEKQLYWMDDDS----- 963
F++ + +A+ + + ++ +P+ G +N ++ D +YW D S
Sbjct: 2062 NSFIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASD 2121
Query: 964 HSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCA--DRDSINATSIDN 1021
++IRR+ G+ + +D + +Y+T A I I N
Sbjct: 2122 NAIRRIKPDGSSLMNIVTHGIGENGVR---GIAVDWVAGNLYFTNAFVSETLIEVLRI-N 2177
Query: 1022 NSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVG-RGAIMRANVDGTGRVELARADNAT-- 1078
+ V+++ +PRH+ RYL W D G R I R+ +D T R L T
Sbjct: 2178 TTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPR 2237
Query: 1079 ALALDQSAGTVYW 1091
LA+D+S G VYW
Sbjct: 2238 GLAVDRSDGYVYW 2250
Score = 301 bits (739), Expect = 9e-81
Identities = 183/589 (31%), Positives = 292/589 (49%), Gaps = 26/589 (4%)
Query: 340 VDFDPKTEYIYWADGLAKTISKARLDGSD-QSVVVRSSGVPDSIAIDPLSRKIYWTDPVM 398
V F + ++W D + + ++G + Q V+ S P+++A+D ++ KIY + +
Sbjct: 429 VAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKV 488
Query: 399 DTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEK--KPKIERANLDGSGR 456
+ I++ LDGSY +I L PR IA+ T G++F+SDW +PK+ERA +DGS R
Sbjct: 489 NRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNR 548
Query: 457 VLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKE-LHSNDII-HIFGXX 514
L+ KL WP + LD ++ ++YW D+R IE DG +RK +H +I H FG
Sbjct: 549 KDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVS 608
Query: 515 XXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFR-LGAPLGWNPCADDNG 573
K + + NK T + Q + GV + L P NPC D+NG
Sbjct: 609 LFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDNNG 668
Query: 574 GCSHLCF--NRPDD----YICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGRLSIK-NE 626
GC +C +R D+ + C C G +L D++ C+ + FL++S + I + +
Sbjct: 669 GCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQNFLIFSSQVAIRGIPFTLST 728
Query: 627 YNDAVIPIK-DLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKI-VEWLGLVEG 684
D ++P+ + + S +++SD I + ++G+ E + + VE
Sbjct: 729 QEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAANRVENVES 788
Query: 685 LAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSE-LG 743
LA DW +N+YWTD+ + I V RL +RR ++ Q L P+S+V+ P GY+++++
Sbjct: 789 LAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV-QYLNNPRSVVVHPFAGYLFFTDWFR 847
Query: 744 SKSIKRAAMDGSS-VSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTL 802
I RA DGS + V +G + LAID+ +YW +E + +G R+ L
Sbjct: 848 PAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRL 907
Query: 803 A--DNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHRAK 860
+ + P+ LA+F + +++ DW G I + RK DG IR + YI LK Y
Sbjct: 908 GHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNI 967
Query: 861 SMGSNQCGV---DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
GSN C NG CSH C P P R C CP RL +++TC
Sbjct: 968 QTGSNACNQPTHPNGDCSHFCFPVPNFQRV---CGCPYGMRLASNHLTC 1013
Score = 299 bits (735), Expect = 3e-80
Identities = 254/928 (27%), Positives = 430/928 (46%), Gaps = 76/928 (8%)
Query: 17 LEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPT-GIAIDWYT 75
++ G V+F + I W + E+ + +T + S +V P+ +A+DW +
Sbjct: 1777 IQNGLDVEFDDAEQYIYWVENPGEIHRV----KTDGTNRTVFASISMVGPSMNLALDWIS 1832
Query: 76 DKLYWTDGETNKIEVISIVQ--KYRKVLFWSE-----VDLARAIAVVPEDGLMFWTDWGE 128
LY T+ T IEV+++ +YRK L ++ V I V P G ++W+D G
Sbjct: 1833 RNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGT 1892
Query: 129 ---IP-KIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNG 184
+P KI A M+G K + N+ +T+D +YW ++ + +G
Sbjct: 1893 DSGVPAKIASANMDGTSV--KTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDG 1950
Query: 185 EKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIK 244
R +V L +P+ + + LY+TD Q I D A KI L + P ++
Sbjct: 1951 TDRMILVHQ-LSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIV-LRDNVPNLRGLQ 2008
Query: 245 VYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPG-YNCACPTGVKLR-ENSSTTCYDSP 302
VY S+ C N C +CL P P G ++CAC TG KL +N S + Y+S
Sbjct: 2009 VYHRRNAAESSNG--CSNNMNACQQICL--PVPGGLFSCACATGFKLNPDNRSCSPYNS- 2063
Query: 303 QMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRT-LTVDFDPKTEYIYWADGLAKTIS- 360
+VV+ S I SL+ D + +P+ R L VD D + +IYW D + S
Sbjct: 2064 --FIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASD 2121
Query: 361 ----KARLDGSDQSVVVRSSGVPDS----IAIDPLSRKIYWTDP-VMDT-INVARLDGSY 410
+ + DGS +V + G+ ++ IA+D ++ +Y+T+ V +T I V R++ +Y
Sbjct: 2122 NAIRRIKPDGSSLMNIV-THGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTY 2180
Query: 411 EKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSI 470
+V++ + PR I + ++FW+D+ ++ PKIER+ LD + R +L+SE + P +
Sbjct: 2181 RRVLLKVTVDMPRHIVVDPKNRYLFWADYGQR-PKIERSFLDCTNRTVLVSEGIVTPRGL 2239
Query: 471 ALDTVNNKLYWGDARTHKIEVCNMDGTERKEL-HSNDIIHIFGXXXXXXXXXXXXMQKRT 529
A+D + +YW D I ++G + + + + +G +
Sbjct: 2240 AVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKK 2299
Query: 530 LDRINKNTGLDRQPVV--EQMANMMGVKAF------RLGAPLGWNPCADDNGGCSHLCFN 581
+ + +K P V + + + V F R A + NPC ++NGGCSHLCF
Sbjct: 2300 IFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFA 2359
Query: 582 RPDDYI--CGCPLGLELTADKKTC-VEPEAFLVYSRKNIIGRLSIKNEYNDAVIPIKDLK 638
P + C C G L +D K C + E FL+++ N + L + E + +++
Sbjct: 2360 LPGLHTPKCDCAFGT-LQSDGKNCAISTENFLIFALSNSLRSLHLDPENHSPPFQTINVE 2418
Query: 639 EVSALALYVSGS-KLYWSDSKTKTINRCSVN--GSAVEK---IVEWLGLVEGLAIDWSGQ 692
Y S S ++Y++ + + + S S + I +G +G+A DW +
Sbjct: 2419 RTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITR 2478
Query: 693 NIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS-IKRAA 751
IY++D Q I DGS+R I + KP++IVLDP +GY+YW++ + + I+RA
Sbjct: 2479 RIYYSDYLNQMINSMAEDGSNRTVIA--RVPKPRAIVLDPCQGYLYWADWDTHAKIERAT 2536
Query: 752 MDGS-SVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPMPY 810
+ G+ V + + L +DYE +YW +E + L G R+ + + +
Sbjct: 2537 LGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAVHAF 2596
Query: 811 ALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLK----LYHRAKSMGSNQ 866
L L+ +YW D T +I +A K DGS + ++ +L +S + + K +N
Sbjct: 2597 GLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNL--LSQPRGINTVVKNQKQQCNNP 2654
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACP 894
C NGGCSH+C P P C CP
Sbjct: 2655 CEQFNGGCSHICAPGPNGA----ECQCP 2678
Score = 294 bits (722), Expect = 1e-78
Identities = 178/616 (28%), Positives = 310/616 (50%), Gaps = 32/616 (5%)
Query: 6 RLTRITTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVT 65
R RI +++ V FHY + W+D + ++ N E + E T
Sbjct: 412 RSFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVE---T 468
Query: 66 PTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTD 125
P +A+DW +K+Y + + N+I+++++ YR L + R IAV P G +F++D
Sbjct: 469 PENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSD 528
Query: 126 WGEI---PKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDF 182
W + PK+ERA M+G + RK +V+ + WP G+T+D + +YWVD++ +++ + +
Sbjct: 529 WESLSGEPKLERAFMDG--SNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTY 586
Query: 183 NGEKRKRVVKGG--LVYPFALTFSNDKLYWTDWQNWSIYTWD-IAANGPKIKELIKSHPV 239
+G +RK VV GG + +PF ++ ++++TDW ++ + P++ ++
Sbjct: 587 DGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQV--YYQASLR 644
Query: 240 PADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLS----PDPPGYNCACPTGVKLRENSS 295
P + VY RQ + PCK NN GC +C+LS D G+ C C G +L +
Sbjct: 645 PYGVTVYHSLRQPYATN--PCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQL-DTDE 701
Query: 296 TTCYDSPQMLLVVAQRSTISKISLDSPDFTPYTLPLK-DLKRTLTVDFDPKTEYIYWADG 354
C + Q L+ + + I I +P+ + + +DFD + I+++D
Sbjct: 702 RHCI-AVQNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDM 760
Query: 355 LAKTISKARLDGSDQSVVV--RSSGVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEK 412
I K ++DG+ + ++ R V +S+A D +S+ +YWTD +I+V RL +
Sbjct: 761 SKHMIFKQKIDGTGREILAANRVENV-ESLAFDWISKNLYWTDSHYKSISVMRLADKTRR 819
Query: 413 VIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIAL 472
++ L +PR++ +H AG++F++DW + KI RA DGS + +I+ L WPN +A+
Sbjct: 820 TVVQ-YLNNPRSVVVHPFAGYLFFTDW-FRPAKIMRAWSDGSHLLPVINTTLGWPNGLAI 877
Query: 473 DTVNNKLYWGDARTHKIEVCNMDGTERKEL-HSNDIIHIFGXXXXXXXXXXXXMQKRTLD 531
D ++LYW DA KIE DG +R+ L H + H FG + +
Sbjct: 878 DWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAII 937
Query: 532 RINKNTGLDRQPVVEQMANMMGVKAFRLGAPLGWNPC---ADDNGGCSHLCFNRPD-DYI 587
R+ K G + + +A ++ +K++ + G N C NG CSH CF P+ +
Sbjct: 938 RVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRV 997
Query: 588 CGCPLGLELTADKKTC 603
CGCP G+ L ++ TC
Sbjct: 998 CGCPYGMRLASNHLTC 1013
Score = 212 bits (517), Expect = 7e-54
Identities = 159/564 (28%), Positives = 267/564 (47%), Gaps = 37/564 (6%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTC----VEPEAFLVYSRKNIIGRLSIKNEYN 628
G CS C+N + C C G L +D +TC E LV S+ II S+ ++ +
Sbjct: 1398 GSCSQHCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKIIAD-SVTSQVH 1456
Query: 629 DAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVE-WLGLVEGLAI 687
+ +++ + A+ +++WSD+ NG+ + + + L E +AI
Sbjct: 1457 NIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAI 1516
Query: 688 DWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPK--KGYMYWSELG-S 744
DW G+N+YWTD + IEVS++DGS R +I + L P+ + LDP+ + ++WS+ G
Sbjct: 1517 DWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHH 1576
Query: 745 KSIKRAAMDGSSVSVFM-EQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNG-TGRQTL 802
I+RA+MDGS +V + +++ L IDY R +Y+ ++F NG RQ +
Sbjct: 1577 PRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVI 1636
Query: 803 ADN--IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHRAK 860
A + I PYAL LF DSVYW D T ++ +A K G N+ + ++ + + H +K
Sbjct: 1637 ASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSK 1696
Query: 861 SMGS-NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC-SEPEEFLLFAQK 918
S N C CSHLCL + Y C CP+ + L+ D + C + + FL+ ++
Sbjct: 1697 QPNSVNPCAFSR--CSHLCLLSSQGPHF-YSCVCPSGWSLSPDLLNCLRDDQPFLITVRQ 1753
Query: 919 NAV-GRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXX 977
+ + G + + NDA +P+ G++N +E+D E+ +YW+++ I RV
Sbjct: 1754 HIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPG-EIHRVKTD--GTN 1810
Query: 978 XXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNN---SSTGVIVRGDRM 1034
G S ++ LD + R +Y T SI ++ + T + G +
Sbjct: 1811 RTVFASISMVGPS--MNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTAL 1868
Query: 1035 ---LPRHLAFHQTKRYLIWNDVGRGA-----IMRANVDGTGRVEL--ARADNATALALDQ 1084
P + + L W+D G + I AN+DGT L ++ + LD
Sbjct: 1869 GVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDI 1928
Query: 1085 SAGTVYWAVSRQCDGQQDCEDGRD 1108
+YWAV+ + ++ DG D
Sbjct: 1929 EEQKLYWAVTGRGVIERGNVDGTD 1952
Score = 199 bits (485), Expect = 6e-50
Identities = 112/340 (32%), Positives = 176/340 (51%), Gaps = 20/340 (5%)
Query: 575 CSHLCFNRPDDYICGCPLGLELTADKKTCVEP---EAFLVYSRKNIIGRLSIKNEYNDAV 631
CS C N YIC C G D KTC + E +L++S + + L+I + +
Sbjct: 3163 CSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLI 3222
Query: 632 IPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEW-LGLVEGLAIDWS 690
+ + L V AL +LYW D++ + I R +N + E I+ L E LA+DW
Sbjct: 3223 L--EGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWV 3280
Query: 691 GQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLK--------KPKSIVLDPKKGYMYWSEL 742
+ +YW D + VS L+G RR + + P+ + L P+ GY+YW++
Sbjct: 3281 SRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADW 3340
Query: 743 GSKS-IKRAAMDGSSVSVFME-QVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQ 800
G ++ I R MDG++ SV + ++ + + IDY +YWA +E++ L G R
Sbjct: 3341 GHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRH 3400
Query: 801 TLADN-IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHRA 859
T+ D +P P+A+ +F D++YW DWNT +++ K DGSNR+++ D+ +YH
Sbjct: 3401 TVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPY 3460
Query: 860 KS-MGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYR 898
+ + SN CG +NGGCSHLCL PG + C CP +R
Sbjct: 3461 RQPIVSNPCGTNNGGCSHLCLIKPGG--KGFTCECPDDFR 3498
Score = 192 bits (468), Expect = 6e-48
Identities = 103/295 (34%), Positives = 154/295 (52%), Gaps = 17/295 (5%)
Query: 13 IAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAID 72
I + L+ A+DF + + W D + ++I+ M N+T K I++ L +A+D
Sbjct: 3222 ILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKT---NKETIINHRLPAAESLAVD 3278
Query: 73 WYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDL--------ARAIAVVPEDGLMFWT 124
W + KLYW D + + V + +R++L VD R +A+ P+ G ++W
Sbjct: 3279 WVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWA 3338
Query: 125 DWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNG 184
DWG I R GM+G + VI+ + WPNGIT+DY N L+YW DA L +++ D G
Sbjct: 3339 DWGHRAYIGRVGMDG--TNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEG 3396
Query: 185 EKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIK 244
R V G L +PFA+T D +YWTDW ++ + +G + L+ + P DI
Sbjct: 3397 HHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGN-KYDGSNRQTLVNTTHRPFDIH 3455
Query: 245 VYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVK-LRENSSTTC 298
VY RQ I + PC NN GCSHLCL+ P G+ C CP + L+ + ST C
Sbjct: 3456 VYHPYRQPIVSN--PCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYC 3508
Score = 177 bits (430), Expect = 3e-43
Identities = 92/237 (38%), Positives = 139/237 (58%), Gaps = 11/237 (4%)
Query: 63 LVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMF 122
++ P GIA+DW +YW+D + +IEV + +YRK L +++D AIAV P+ GLMF
Sbjct: 4141 VMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMF 4200
Query: 123 WTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDY-NNSLIYWVDAKLQFVDVID 181
WTDWG+ PKIE A MNG+ R ++V +++ WP G+++DY NN IYW D K ++ I
Sbjct: 4201 WTDWGKEPKIESAWMNGE--DRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIK 4258
Query: 182 FNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPA 241
++G R RV+ + P++L D+LYW + ++ + G K K L+ +P
Sbjct: 4259 YDGTDR-RVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLV-VNPWLT 4316
Query: 242 DIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTC 298
++++ + R S + CK+ CSHLCLL P GY+CACP G E S+T C
Sbjct: 4317 QVRIFHQLRYNKSVPNL-CKQI---CSHLCLLRPG--GYSCACPQGSSFIEGSTTEC 4367
Score = 172 bits (418), Expect = 7e-42
Identities = 97/326 (29%), Positives = 164/326 (50%), Gaps = 19/326 (5%)
Query: 280 YNCACPTGVKLRENSSTTCYDSPQM--LLVVAQRSTISKISLDSPDFTPYTLPLKDLKRT 337
Y C C G LRE TC + + L+ + R + +++D Y+L L+ L
Sbjct: 3174 YICKCAPGY-LREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYF---YSLILEGLDNV 3229
Query: 338 LTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSS-GVPDSIAIDPLSRKIYWTDP 396
+ +DFD + +YW D + I + L+ +++ ++ +S+A+D +SRK+YW D
Sbjct: 3230 VALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDA 3289
Query: 397 VMDTINVARLDGSYEKVII-------HTELYD-PRAIALHLTAGWMFWSDWNEKKPKIER 448
+D + V+ L+G + +++ +T +D PR +ALH G+++W+DW + I R
Sbjct: 3290 RLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRA-YIGR 3348
Query: 449 ANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDII 508
+DG+ + ++IS KL WPN I +D N+ LYW DA IE +++G R ++ +
Sbjct: 3349 VGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALP 3408
Query: 509 HIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFR-LGAPLGWNP 567
H F RT+++ NK G +RQ +V + + P+ NP
Sbjct: 3409 HPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNP 3468
Query: 568 CADDNGGCSHLCFNRP--DDYICGCP 591
C +NGGCSHLC +P + C CP
Sbjct: 3469 CGTNNGGCSHLCLIKPGGKGFTCECP 3494
Score = 167 bits (406), Expect = 2e-40
Identities = 135/565 (23%), Positives = 247/565 (43%), Gaps = 36/565 (6%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTCVEP---EAFLVYS--RKNIIGRLSIKNEY 627
G C C +RP ++C C G L + EA +++S R +IG I
Sbjct: 356 GICDQKCESRPGRHLCHCEEGYILERGQYCKANDSFGEASIIFSNGRDLLIG--DIHGRS 413
Query: 628 NDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEW-LGLVEGLA 686
++ ++ +A + +++W+D+ + +NG +++++ + E LA
Sbjct: 414 FRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLA 473
Query: 687 IDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMY---WSEL- 742
+DW IY +T RI++ LDGS R +I + L P+ I +DP GY++ W L
Sbjct: 474 VDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLS 533
Query: 743 GSKSIKRAAMDGSSVSVFME-QVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQT 801
G ++RA MDGS+ ++ ++G + +D + +YW +E +G R+T
Sbjct: 534 GEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKT 593
Query: 802 LADN---IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHR 858
+ IP P+ ++LF V++ DW + +A K +N + + + +YH
Sbjct: 594 VVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHS 653
Query: 859 AKS-MGSNQCGVDNGGCSHLCLPTPGDVRTD-----YRCACPAHYRLNKDNITCSEPEEF 912
+ +N C +NGGC +C+ + RTD +RC C ++L+ D C + F
Sbjct: 654 LRQPYATNPCKDNNGGCEQVCVLSH---RTDNDGLGFRCKCTFGFQLDTDERHCIAVQNF 710
Query: 913 LLFAQKNAVGRIMVANGECNDAYIPLTGLKN-VRAIEYDPVEKQLYWMDDDSHSIRRVPI 971
L+F+ + A+ I D +P++G + I++D + +++ D H I + I
Sbjct: 711 LIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKI 770
Query: 972 SYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRG 1031
+ + D + + +YWT + SI+ + + + V+
Sbjct: 771 D-----GTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVVQYL 825
Query: 1032 DRMLPRHLAFHQTKRYLIWNDVGRGA-IMRANVDGTGRVELARADNA--TALALDQSAGT 1088
+ PR + H YL + D R A IMRA DG+ + + LA+D +A
Sbjct: 826 NN--PRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASR 883
Query: 1089 VYWAVSRQCDGQQDCEDGRDEAECG 1113
+YW + + DG D G
Sbjct: 884 LYWVDAYFDKIEHSTFDGLDRRRLG 908
Score = 136 bits (329), Expect = 4e-31
Identities = 103/354 (29%), Positives = 173/354 (48%), Gaps = 33/354 (9%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADK--KTCV-EPEAFLVYSRKNI-IGRL 621
N C + G C C N Y C C G +D+ K C E + L+ N+ I +
Sbjct: 4009 NEC-EQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKY 4067
Query: 622 SIKNE----------YNDAVIPIKDLKEVSALALY--VSGSKLYWSDSKTKTI-NRCSVN 668
++ +E Y AV D K++ +Y V G + K I N S
Sbjct: 4068 NLSSERFSEYLQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGR 4127
Query: 669 GSAVEKI---VEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKP 725
+ V+++ ++++ +G+A+DW G++IYW+D +RIEV++LDG R+ +I L +P
Sbjct: 4128 NNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQP 4187
Query: 726 KSIVLDPKKGYMYWSELGSK-SIKRAAMDGSSVSVFM-EQVGRVHALAIDY-ERRAIYWA 782
+I ++PK G M+W++ G + I+ A M+G ++ + E +G L+IDY IYW+
Sbjct: 4188 AAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWS 4247
Query: 783 ALDPPVVEFAFLNGTGRQTLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKS 842
V+E +GT R+ +A PY+L +F D +YW G++ + K ++
Sbjct: 4248 DFKEDVIETIKYDGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEK 4307
Query: 843 IRKDLDYISDLKLYHRAKSMGS--NQCGVDNGGCSHLCLPTPGDVRTDYRCACP 894
+++ ++++H+ + S N C CSHLCL PG Y CACP
Sbjct: 4308 TLVVNPWLTQVRIFHQLRYNKSVPNLC---KQICSHLCLLRPG----GYSCACP 4354
Score = 135 bits (326), Expect = 1e-30
Identities = 100/335 (29%), Positives = 159/335 (47%), Gaps = 27/335 (8%)
Query: 280 YNCACPTG-VKLRENSSTTCY-DSPQMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRT 337
Y C C G + + C + LL++ I K +L S F+ Y L ++ +
Sbjct: 4028 YECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEY-LQDEEYIQA 4086
Query: 338 LTVDFDPKT---EYIYWA---DGLA-KTISKARLDGSD-------QSVVVRSSGV--PDS 381
+ D+DPK +Y+ +G I +A + + Q V ++ V PD
Sbjct: 4087 VDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDG 4146
Query: 382 IAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNE 441
IA+D + R IYW+D I VA+LDG Y K +I T+L P AIA++ G MFW+DW
Sbjct: 4147 IAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWG- 4205
Query: 442 KKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNN-KLYWGDARTHKIEVCNMDGTERK 500
K+PKIE A ++G R +L+ E L WP +++D +NN ++YW D + IE DGT+R+
Sbjct: 4206 KEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRR 4265
Query: 501 ELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFRLG 560
+ + + ++ + +K + + NK ++ + + V+ F
Sbjct: 4266 VI-AKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFH-- 4322
Query: 561 APLGWNPCADD--NGGCSHLCFNRPDDYICGCPLG 593
L +N + CSHLC RP Y C CP G
Sbjct: 4323 -QLRYNKSVPNLCKQICSHLCLLRPGGYSCACPQG 4356
Score = 77.0 bits (181), Expect = 4e-13
Identities = 69/245 (28%), Positives = 109/245 (44%), Gaps = 13/245 (5%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQ--MLLVVAQRSTISKI 317
C N GC+H C+ +P G C CP G L N S TC D + +L +Q +
Sbjct: 1353 CSDFNGGCTHECV--QEPFGAKCLCPLGF-LLANDSKTCEDIDECDILGSCSQHCYNMRG 1409
Query: 318 SLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSG 377
S T Y L+ RT V + + S + S+V S
Sbjct: 1410 SFRCSCDTGYM--LESDGRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSLVENGSY 1467
Query: 378 VPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWS 437
+ ++ D +S +I+W+D A +G+ +V+ + + IA+ ++W+
Sbjct: 1468 IV-AVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWT 1526
Query: 438 DWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNK--LYWGDARTH-KIEVCNM 494
D+ IE + +DGS R +LIS+ LT P +ALD N+ L+W D H +IE +M
Sbjct: 1527 DY--ALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASM 1584
Query: 495 DGTER 499
DG+ R
Sbjct: 1585 DGSMR 1589
Score = 70.5 bits (165), Expect = 3e-11
Identities = 68/263 (25%), Positives = 116/263 (44%), Gaps = 22/263 (8%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE-PEAFLVYSRK----NIIG- 619
N C+D NGGC+H C P C CPLG L D KTC + E ++ S N+ G
Sbjct: 1351 NSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRGS 1410
Query: 620 -RLSIKNEY--NDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIV 676
R S Y K S L L S +K+ +DS T ++ + +V
Sbjct: 1411 FRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKII-ADSVTSQVHN-------IYSLV 1462
Query: 677 EWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGY 736
E + + D I+W+D T + + +G+ RR + + ++I +D
Sbjct: 1463 ENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRN 1522
Query: 737 MYWSELGSKSIKRAAMDGSSVSVFM-EQVGRVHALAID--YERRAIYWAAL-DPPVVEFA 792
+YW++ ++I+ + +DGS +V + + + LA+D ++W+ P +E A
Sbjct: 1523 LYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERA 1582
Query: 793 FLNGTGRQTLA-DNIPMPYALAL 814
++G+ R + D I P L +
Sbjct: 1583 SMDGSMRTVIVQDKIFWPCGLTI 1605
Score = 67.3 bits (157), Expect = 3e-10
Identities = 71/301 (23%), Positives = 127/301 (42%), Gaps = 29/301 (9%)
Query: 564 GWNPCADDN-GGCSHLCFNRPDDYICGCPLGLELTADKKTCVE----PEAFLVYSRK--N 616
G N C D + GC H C + + C C G +L +DK+TCV+ E V S+K N
Sbjct: 3110 GINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCEN 3169
Query: 617 IIGRLSIKNEYNDAVIPI-KDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKI 675
+IG K P K ++ S + Y+ S Y+ + +++G I
Sbjct: 3170 VIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYY-------LRNLTIDGYFYSLI 3222
Query: 676 VEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKG 735
+E L V L D + +YW DT Q IE L+ +++ II L +S+ +D
Sbjct: 3223 LEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSR 3282
Query: 736 YMYWSELGSKSIKRAAMDGSSVSVFMEQ---------VGRVHALAIDYERRAIYWAAL-D 785
+YW + + + ++G + + LA+ + +YWA
Sbjct: 3283 KLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGH 3342
Query: 786 PPVVEFAFLNGTGRQT-LADNIPMPYALAL--FNDSVYWGDWNTGQIQQARKTDGSNRKS 842
+ ++GT + ++ + P + + ND +YW D + G I+ + +G +R +
Sbjct: 3343 RAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYS-DLEGHHRHT 3401
Query: 843 I 843
+
Sbjct: 3402 V 3402
Score = 66.9 bits (156), Expect = 4e-10
Identities = 64/249 (25%), Positives = 103/249 (41%), Gaps = 24/249 (9%)
Query: 860 KSMGSNQCGVDNGGCSHL---CLPTPGDVRTDYRCACPAHYRLNKDNITC---SEPEEFL 913
K M + VD C+ + C +V Y C C Y D TC S E +L
Sbjct: 3142 KLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYL 3201
Query: 914 LFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISY 973
+F+ + + R + +G + L GL NV A+++D VEK+LYW+D I R+ ++
Sbjct: 3202 IFSNRYYL-RNLTIDGYFYS--LILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLN- 3257
Query: 974 XXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGV---IVR 1030
L + +D + R +YW A D + + ++ + V
Sbjct: 3258 ----KTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVD 3313
Query: 1031 GDRML----PRHLAFHQTKRYLIWNDVG-RGAIMRANVDGTGR--VELARADNATALALD 1083
+ PR LA H YL W D G R I R +DGT + + + + + +D
Sbjct: 3314 ANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITID 3373
Query: 1084 QSAGTVYWA 1092
+ +YWA
Sbjct: 3374 YTNDLLYWA 3382
Score = 66.5 bits (155), Expect = 5e-10
Identities = 65/249 (26%), Positives = 95/249 (38%), Gaps = 27/249 (10%)
Query: 945 RAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTM 1004
RAI DP + LYW D D+H+ I L P + LD +
Sbjct: 2510 RAIVLDPCQGYLYWADWDTHA----KIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLL 2565
Query: 1005 YWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTK-----RYLIWNDVGRGAIM 1059
YW A I +++ TGV DR + + A H +Y+ W D+ I
Sbjct: 2566 YWVDASLQRIERSTL-----TGV----DREVIVNAAVHAFGLTLYGQYIYWTDLYTQRIY 2616
Query: 1060 RAN-VDGTGRVELARADNATALALDQSAGTVYWAVSRQCDGQQDCEDGRDEAEC--GACG 1116
RAN DG+G++ + L+ + TV +QC+ + +G C G G
Sbjct: 2617 RANKYDGSGQIAMT----TNLLSQPRGINTVVKNQKQQCNNPCEQFNGGCSHICAPGPNG 2672
Query: 1117 GDVRCA-DGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDEA 1175
+ +C +G +F C G CI+ + CD C DGSDE
Sbjct: 2673 AECQCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGRCISEEWKCDNDNDCGDGSDEM 2732
Query: 1176 PAACAYGHT 1184
+ CA HT
Sbjct: 2733 ESVCAL-HT 2740
Score = 53.2 bits (122), Expect = 5e-06
Identities = 42/190 (22%), Positives = 82/190 (43%), Gaps = 13/190 (6%)
Query: 35 SDQKPELIQCMNY---NETYTGEKFKIVSEGLVTPTGIAIDWYTDKLYWTDGETNKIEVI 91
S+ +P LI Y N T G + ++ EGL + D +LYW D + IE +
Sbjct: 3195 SNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERM 3254
Query: 92 SIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERAGMNGD---PATRKVIV 148
+ + ++ + + A ++AV ++W D + + + +NG + +
Sbjct: 3255 FLNKTNKETIINHRLPAAESLAVDWVSRKLYWLD-ARLDGLFVSDLNGGHRRMLAQHCVD 3313
Query: 149 RDNIFW---PNGITVDYNNSLIYWVD-AKLQFVDVIDFNGEKRKRVVKGGLVYPFALT-- 202
+N F P G+ + +YW D ++ + +G + ++ L +P +T
Sbjct: 3314 ANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITID 3373
Query: 203 FSNDKLYWTD 212
++ND LYW D
Sbjct: 3374 YTNDLLYWAD 3383
Score = 48.8 bits (111), Expect = 1e-04
Identities = 37/118 (31%), Positives = 44/118 (37%), Gaps = 23/118 (19%)
Query: 1097 CDGQQDCEDGRDEAEC--GACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDA------- 1147
CDG +DC DG DE C +CA G +A
Sbjct: 1168 CDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPP 1227
Query: 1148 -------FRCDE-GLCIAARFVCDGRPQCADGSDE----APAAC--AYGHTDQVNGIH 1191
F+C E G+CI + CDG P C GSDE P C +Y H D N IH
Sbjct: 1228 GMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIH 1285
Score = 43.2 bits (97), Expect = 0.006
Identities = 62/276 (22%), Positives = 101/276 (36%), Gaps = 35/276 (12%)
Query: 834 KTDGSNRKSIRKDLDYISDLKLYHRAKSMGSNQCGVDN-GGCSHLCLPTPGDVRTDYRCA 892
K D + K +++ D K G N+C + GC H C D T + C+
Sbjct: 3081 KCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISGCDHNCT----DTLTSFYCS 3136
Query: 893 CPAHYRLNKDNITCSEPEEF----LLFAQK--NAVGRIMVANGECNDAYIPLTGLKNVRA 946
C Y+L D TC + +E + +QK N +G + +C Y+ K R
Sbjct: 3137 CRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYIC---KCAPGYLREPDGKTCR- 3192
Query: 947 IEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYW 1006
+ +E Y + + + +R + I GL + D + + +YW
Sbjct: 3193 -QNSNIEP--YLIFSNRYYLRNLTID------GYFYSLILEGLDNVVALDFDRVEKRLYW 3243
Query: 1007 TCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGAIMRANVDGT 1066
R I + N ++ I+ LA R L W D + ++++G
Sbjct: 3244 IDTQRQVIERMFL-NKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGG 3302
Query: 1067 GRVELAR----------ADNATALALDQSAGTVYWA 1092
R LA+ DN LAL G +YWA
Sbjct: 3303 HRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWA 3338
Score = 42.3 bits (95), Expect = 0.010
Identities = 38/130 (29%), Positives = 46/130 (35%), Gaps = 20/130 (15%)
Query: 1063 VDGTGRVELARADNATALALDQSAGTVYWAVSRQCDGQQDCEDGRDEAEC-----GACGG 1117
VDG+ V N TA ++G V+ +CDG DC D DEA C G C
Sbjct: 1175 VDGSDEVGCVL--NCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHS 1232
Query: 1118 D-VRC------------ADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDG 1164
D +C DG F CD G CI ++CD
Sbjct: 1233 DEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLCDR 1292
Query: 1165 RPQCADGSDE 1174
C D SDE
Sbjct: 1293 DNDCGDMSDE 1302
Score = 42.3 bits (95), Expect = 0.010
Identities = 40/153 (26%), Positives = 75/153 (49%), Gaps = 13/153 (8%)
Query: 20 GTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAIDWYTDKLY 79
G AVD+ R I WSD K + I+ + Y K+ ++S L P IA++ ++
Sbjct: 4146 GIAVDWVGRH--IYWSDVKNKRIEVAKLDGRY--RKW-LISTDLDQPAAIAVNPKLGLMF 4200
Query: 80 WTD-GETNKIEVISIVQKYRKVLFWSEVDLARAIAV-VPEDGLMFWTDWGEIPKIERAGM 137
WTD G+ KIE + + R +L + ++ +++ + ++W+D+ E IE
Sbjct: 4201 WTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKE-DVIETIKY 4259
Query: 138 NGDPATRKVIVRDNIFWPNGITVDYNNSLIYWV 170
+G R+VI ++ + N ++D +YW+
Sbjct: 4260 DG--TDRRVIAKEAM---NPYSLDIFEDQLYWI 4287
Score = 41.9 bits (94), Expect = 0.013
Identities = 27/92 (29%), Positives = 51/92 (55%), Gaps = 7/92 (7%)
Query: 13 IAKDLEQGTAVDFHYRKNLICWSD--QKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIA 70
I+ DL+Q A+ + + L+ W+D ++P++ E ++ +V E L PTG++
Sbjct: 4180 ISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGE----DRNILVFEDLGWPTGLS 4235
Query: 71 IDWY-TDKLYWTDGETNKIEVISIVQKYRKVL 101
ID+ D++YW+D + + IE I R+V+
Sbjct: 4236 IDYLNNDRIYWSDFKEDVIETIKYDGTDRRVI 4267
Score = 41.5 bits (93), Expect = 0.018
Identities = 31/89 (34%), Positives = 34/89 (38%), Gaps = 30/89 (33%)
Query: 1097 CDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCI 1156
CDG DC D DE CG C+ AF C G CI
Sbjct: 1045 CDGVDDCHDNSDEQLCGTLNNT--CSSS----------------------AFTCGHGECI 1080
Query: 1157 AARFVCDGRPQCADGSDE------APAAC 1179
A + CD R C DGSDE APA+C
Sbjct: 1081 PAHWRCDKRNDCVDGSDEHNCPTHAPASC 1109
Score = 41.5 bits (93), Expect = 0.018
Identities = 29/108 (26%), Positives = 39/108 (36%), Gaps = 9/108 (8%)
Query: 1068 RVELARADNATALALDQSAGTVYWAVSRQCDGQQ-DCEDGRDEAECGACGGDVRCADGTX 1126
RV L DN D S + + C + C GR + C + C D +
Sbjct: 2838 RVYLCDGDNDCG---DNSDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASD 2894
Query: 1127 XXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
D F+CD G CI + ++CDG C D SDE
Sbjct: 2895 EPASCGHSERTCLA-----DEFKCDGGRCIPSEWICDGDNDCGDMSDE 2937
Score = 41.1 bits (92), Expect = 0.023
Identities = 31/90 (34%), Positives = 36/90 (40%), Gaps = 27/90 (30%)
Query: 1090 YWAVSRQCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFR 1149
YW +CDG DC DG DE E C DV C + FR
Sbjct: 3858 YW----KCDGDDDCGDGSDE-ELHLCL-DVPC---------------------NSPNRFR 3890
Query: 1150 CDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
CD CI + VC+G C DG+DE C
Sbjct: 3891 CDNNRCIYSHEVCNGVDDCGDGTDETEEHC 3920
Score = 40.7 bits (91), Expect = 0.031
Identities = 27/93 (29%), Positives = 33/93 (35%), Gaps = 13/93 (13%)
Query: 1096 QCDGQQDCEDGRDEAECGA--CG-GDVRCADGTXXXXX----------XXXXXXXXXXXX 1142
QCDGQ DC D DE C C + RC +
Sbjct: 3738 QCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRT 3797
Query: 1143 XXXDAFRCDEGLCIAARFVCDGRPQCADGSDEA 1175
+ F+C G C+ + CDG C D SDEA
Sbjct: 3798 CHPEYFQCTSGHCVHSELKCDGSADCLDASDEA 3830
Score = 39.9 bits (89), Expect = 0.054
Identities = 27/84 (32%), Positives = 31/84 (36%), Gaps = 21/84 (25%)
Query: 1096 QCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLC 1155
+CDG DC D DEA+C R DG F C +C
Sbjct: 3816 KCDGSADCLDASDEADC-----PTRFPDGAYCQATM----------------FECKNHVC 3854
Query: 1156 IAARFVCDGRPQCADGSDEAPAAC 1179
I + CDG C DGSDE C
Sbjct: 3855 IPPYWKCDGDDDCGDGSDEELHLC 3878
Score = 39.5 bits (88), Expect = 0.071
Identities = 29/97 (29%), Positives = 36/97 (37%), Gaps = 14/97 (14%)
Query: 1096 QCDGQQDCEDGRDEAECG--ACGGDVRCADGTXXXXXXX---------XXXXXXXXXXXX 1144
+CD +DC DG DE +C C + C +G
Sbjct: 126 RCDHVRDCPDGADENDCQYPTCE-QLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEICL 184
Query: 1145 XDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAACAY 1181
+ F C G CI +VCD C DGSDE AC Y
Sbjct: 185 HNEFSCGNGECIPRAYVCDHDNDCQDGSDE--HACNY 219
Score = 39.5 bits (88), Expect = 0.071
Identities = 16/32 (50%), Positives = 17/32 (53%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F C G CI+ FVCD C DGSDE C
Sbjct: 3037 FTCQNGRCISKTFVCDEDNDCGDGSDELMHLC 3068
Score = 39.1 bits (87), Expect = 0.094
Identities = 23/73 (31%), Positives = 28/73 (38%), Gaps = 6/73 (8%)
Query: 1103 CEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVC 1162
C +GR +E C D C DG+ AF C G C+ + C
Sbjct: 2707 CSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPT------AFTCANGRCVQYSYRC 2760
Query: 1163 DGRPQCADGSDEA 1175
D C DGSDEA
Sbjct: 2761 DYYNDCGDGSDEA 2773
Score = 38.7 bits (86), Expect = 0.12
Identities = 17/47 (36%), Positives = 24/47 (51%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
N C NGGC+H C+ P +C CP + L D+ TC + +E
Sbjct: 1351 NSCSDFNGGCTHECVQEPFGA----KCLCPLGFLLANDSKTCEDIDE 1393
Score = 37.9 bits (84), Expect = 0.22
Identities = 23/77 (29%), Positives = 29/77 (37%), Gaps = 7/77 (9%)
Query: 1098 DGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIA 1157
D Q C++ + ++ C D C DG+ F C CI
Sbjct: 1111 DTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQ-------FNCPNHRCID 1163
Query: 1158 ARFVCDGRPQCADGSDE 1174
FVCDG C DGSDE
Sbjct: 1164 LSFVCDGDKDCVDGSDE 1180
Score = 37.9 bits (84), Expect = 0.22
Identities = 30/101 (29%), Positives = 38/101 (37%), Gaps = 16/101 (15%)
Query: 1096 QCDGQQDCEDGRDE-AECGA--CG-GDVRCADGTXXXXXXXXXXXXXXXXXXXXD----- 1146
+CDGQ+DC DG DE A C C G +C+DG D
Sbjct: 3531 KCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCE 3590
Query: 1147 -------AFRCDEGLCIAARFVCDGRPQCADGSDEAPAACA 1180
++C CI + CD C D SDE + CA
Sbjct: 3591 NHHCDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSSHCA 3631
Score = 37.9 bits (84), Expect = 0.22
Identities = 14/38 (36%), Positives = 20/38 (52%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAACAYGHTD 1185
F+C +G C + + +C+ C DGSDE C H D
Sbjct: 3558 FQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCD 3595
Score = 37.5 bits (83), Expect = 0.29
Identities = 26/93 (27%), Positives = 32/93 (34%), Gaps = 12/93 (12%)
Query: 1094 SRQCDGQQDCEDGRDEAECGA-C-GGDVRCADGTXXXXXXXXXXXXXXXXXXXXDA---- 1147
S++CD + DC D DE C C + C +G A
Sbjct: 161 SQKCDWKVDCRDSSDEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYP 220
Query: 1148 ------FRCDEGLCIAARFVCDGRPQCADGSDE 1174
F C G CI +VCDG C D DE
Sbjct: 221 TCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDE 253
Score = 37.5 bits (83), Expect = 0.29
Identities = 19/44 (43%), Positives = 21/44 (47%), Gaps = 3/44 (6%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDE---APAACAYGHTDQVN 1188
FRC CI R+ CDG+ C D SDE AP C VN
Sbjct: 3725 FRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVN 3768
Score = 37.1 bits (82), Expect = 0.38
Identities = 17/39 (43%), Positives = 21/39 (53%), Gaps = 3/39 (7%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDE---APAACAYGH 1183
FRC G CI A + CDG C+D +DE A C G+
Sbjct: 33 FRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGY 71
Score = 36.3 bits (80), Expect = 0.66
Identities = 23/90 (25%), Positives = 33/90 (36%), Gaps = 4/90 (4%)
Query: 1100 QQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAAR 1159
Q C++GR ++ C D C DG+ F+CD G CI
Sbjct: 3036 QFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHE----FKCDNGRCIEMM 3091
Query: 1160 FVCDGRPQCADGSDEAPAACAYGHTDQVNG 1189
+C+ C D SDE H ++G
Sbjct: 3092 KLCNHLDDCLDNSDEKGCGINECHDPSISG 3121
Score = 35.9 bits (79), Expect = 0.87
Identities = 25/76 (32%), Positives = 30/76 (39%), Gaps = 4/76 (5%)
Query: 1101 QDCEDGRDEAECGAC-GGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCD-EGLCIAA 1158
Q+C+ G C D RC DGT F+C EG CI +
Sbjct: 26 QECDSAHFRCGSGHCIPADWRC-DGTKDCSDDADEIGCAVVTCQQG-YFKCQSEGQCIPS 83
Query: 1159 RFVCDGRPQCADGSDE 1174
+VCD C DGSDE
Sbjct: 84 SWVCDQDQDCDDGSDE 99
Score = 35.9 bits (79), Expect = 0.87
Identities = 25/77 (32%), Positives = 27/77 (35%), Gaps = 9/77 (11%)
Query: 1105 DGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDG 1164
D R + C GDV C DG + F C GLCI F CD
Sbjct: 2962 DRRCIPQSWVCDGDVDCTDG-------YDENQNCTRRTCSENEFTCGYGLCIPKIFRCDR 3014
Query: 1165 RPQCADGSDEAPAACAY 1181
C D SDE C Y
Sbjct: 3015 HNDCGDYSDE--RGCLY 3029
Score = 33.9 bits (74), Expect = 3.5
Identities = 12/29 (41%), Positives = 16/29 (55%)
Query: 1151 DEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
+ +CI ++CDG C D SDE P C
Sbjct: 2831 NSNICIPRVYLCDGDNDCGDNSDENPTYC 2859
Score = 33.5 bits (73), Expect = 4.7
Identities = 12/28 (42%), Positives = 16/28 (57%)
Query: 1147 AFRCDEGLCIAARFVCDGRPQCADGSDE 1174
+F C G C+ ++CDG C D SDE
Sbjct: 1030 SFPCKNGRCVPNYYLCDGVDDCHDNSDE 1057
Score = 33.1 bits (72), Expect = 6.2
Identities = 17/54 (31%), Positives = 25/54 (46%)
Query: 1039 LAFHQTKRYLIWNDVGRGAIMRANVDGTGRVELARADNATALALDQSAGTVYWA 1092
+AF R + ++D I DG+ R +AR A+ LD G +YWA
Sbjct: 2471 IAFDWITRRIYYSDYLNQMINSMAEDGSNRTVIARVPKPRAIVLDPCQGYLYWA 2524
>AY265358-1|AAP88586.1| 4655|Homo sapiens glycoprotein receptor
gp330/megalin precursor protein.
Length = 4655
Score = 439 bits (1081), Expect = e-122
Identities = 322/1138 (28%), Positives = 545/1138 (47%), Gaps = 72/1138 (6%)
Query: 4 TSRLTRITTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGL 63
TS++ I ++ ++ AVDF I WSD Q ++ G ++V +
Sbjct: 1452 TSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDAT----QGKTWSAFQNGTDRRVVFDSS 1507
Query: 64 VTPTG-IAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPE--DGL 120
+ T IAIDW LYWTD IEV I +R VL + R +A+ P + L
Sbjct: 1508 IILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHL 1567
Query: 121 MFWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVI 180
+FW+DWG P+IERA M+G + R VIV+D IFWP G+T+DY N L+Y++D+ L ++D
Sbjct: 1568 LFWSDWGHHPRIERASMDG--SMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFC 1625
Query: 181 DFNGEKRKRVVKGGLV--YPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHP 238
D+NG R++V+ L+ +P+ALT D +YWTD + + +G ++ +
Sbjct: 1626 DYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRAN-KWHGGNQSVVMYNIQ 1684
Query: 239 VPADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPG-YNCACPTGVKLRENSSTT 297
P I S+Q S PC + CSHLCLLS P Y+C CP+G L +
Sbjct: 1685 WPLGIVAVHPSKQPNSVN--PCAFSR--CSHLCLLSSQGPHFYSCVCPSGWSLSPD-LLN 1739
Query: 298 CYDSPQMLLVVAQRSTISKISLD-SPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLA 356
C Q L+ ++ I ISL+ +P+ ++ L V+FD +YIYW +
Sbjct: 1740 CLRDDQPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPG 1799
Query: 357 KTISKARLDGSDQSVVVRSSGVPDS--IAIDPLSRKIYWTDPVMDTINVARLDGS--YEK 412
+ I + + DG++++V S V S +A+D +SR +Y T+P +I V L G Y K
Sbjct: 1800 E-IHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRK 1858
Query: 413 VIIHTE-----LYDPRAIALHLTAGWMFWSDWNEKK---PKIERANLDGSGRVLLISEKL 464
+I + + P I + G ++WSD KI AN+DG+ L + L
Sbjct: 1859 TLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNL 1918
Query: 465 TWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXXXXXXXXXX 524
+ LD KLYW IE N+DGT+R L + + H +G
Sbjct: 1919 EHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMIL-VHQLSHPWGIAVHDSFLYYTD 1977
Query: 525 MQKRTLDRINKNTGLDRQPVVEQMANMMGVKAF-RLGAPLGWNPCADDNGGCSHLCFNRP 583
Q ++R++K TG ++ + + + N+ G++ + R A N C+++ C +C P
Sbjct: 1978 EQYEVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNNMNACQQICLPVP 2037
Query: 584 DD-YICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGRLSIK-NEYNDAVIPIKDL-KEV 640
+ C C G +L D ++C +F+V S + I S++ +++++ ++P+ +
Sbjct: 2038 GGLFSCACATGFKLNPDNRSCSPYNSFIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNA 2097
Query: 641 SALALYVSGSKLYWSD-----SKTKTINRCSVNGSAVEKIV-EWLGL--VEGLAIDWSGQ 692
+ + VS +YW D + I R +GS++ IV +G V G+A+DW
Sbjct: 2098 LHVDVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAG 2157
Query: 693 NIYWTDTTTQR--IEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSK-SIKR 749
N+Y+T+ IEV R++ + RR ++ + P+ IV+DPK Y++W++ G + I+R
Sbjct: 2158 NLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQRPKIER 2217
Query: 750 AAMDGSSVSVFM-EQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTL--ADNI 806
+ +D ++ +V + E + LA+D +YW ++ +NG + +
Sbjct: 2218 SFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRY 2277
Query: 807 PMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKS--IRKDLDYISDLKLYHR------ 858
P PY + +F +S+ W D N +I QA K + IR +++++ D+ ++ +
Sbjct: 2278 PTPYGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRS 2337
Query: 859 AKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS-EPEEFLLFAQ 917
+ +N C +NGGCSHLC PG + T +C C A L D C+ E FL+FA
Sbjct: 2338 PAEVNNNPCLENNGGCSHLCFALPG-LHTP-KCDC-AFGTLQSDGKNCAISTENFLIFAL 2394
Query: 918 KNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXX 977
N++ + + + + + + V +++YD V ++Y+ + + + + ISY
Sbjct: 2395 SNSLRSLHLDPENHSPPFQTINVERTVMSLDYDSVSDRIYFTQNLASGVGQ--ISYATLS 2452
Query: 978 XXXXX-XXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLP 1036
G+ + D + R +Y++ IN+ + D ++ T VI R + P
Sbjct: 2453 SGIHTPTVIASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNRT-VIARVPK--P 2509
Query: 1037 RHLAFHQTKRYLIWNDVGRGA-IMRANVDGTGRVELARAD--NATALALDQSAGTVYW 1091
R + + YL W D A I RA + G RV + + + L LD +YW
Sbjct: 2510 RAIVLDPCQGYLYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYW 2567
Score = 362 bits (890), Expect = 5e-99
Identities = 252/853 (29%), Positives = 424/853 (49%), Gaps = 54/853 (6%)
Query: 280 YNCACPTGVKLRENSSTTC--YDSPQMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRT 337
+ C+C TG L E+ TC S +LL+VA ++ I S+ S Y+L +++
Sbjct: 1411 FRCSCDTGYML-ESDGRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSL-VENGSYI 1468
Query: 338 LTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGV-PDSIAIDPLSRKIYWTDP 396
+ VDFD + I+W+D A +G+D+ VV SS + ++IAID + R +YWTD
Sbjct: 1469 VAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDY 1528
Query: 397 VMDTINVARLDGSYEKVIIHTELYDPRAIAL--HLTAGWMFWSDWNEKKPKIERANLDGS 454
++TI V+++DGS+ V+I L +PR +AL + +FWSDW P+IERA++DGS
Sbjct: 1529 ALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGH-HPRIERASMDGS 1587
Query: 455 GRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDII--HIFG 512
R +++ +K+ WP + +D N LY+ D+ ++ C+ +G R+++ ++D+I H +
Sbjct: 1588 MRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYA 1647
Query: 513 XXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFRLG-APLGWNPCADD 571
R + R NK G ++ V+ + +G+ A P NPCA
Sbjct: 1648 LTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFS 1707
Query: 572 NGGCSHLCF---NRPDDYICGCPLGLELTADKKTCV-EPEAFLVYSRKNIIGRLSIKNEY 627
CSHLC P Y C CP G L+ D C+ + + FL+ R++II +S+ E
Sbjct: 1708 R--CSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNCLRDDQPFLITVRQHIIFGISLNPEV 1765
Query: 628 --NDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGS--AVEKIVEWLGLVE 683
NDA++PI ++ + + +YW ++ + I+R +G+ V + +G
Sbjct: 1766 KSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPGE-IHRVKTDGTNRTVFASISMVGPSM 1824
Query: 684 GLAIDWSGQNIYWTDTTTQRIEVSRLDGS--SRRAIIWQ-----GLKKPKSIVLDPKKGY 736
LA+DW +N+Y T+ TQ IEV L G R+ +I G+ P I +DP +G
Sbjct: 1825 NLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGK 1884
Query: 737 MYWSELGSKS-----IKRAAMDGSSV-SVFMEQVGRVHALAIDYERRAIYWAALDPPVVE 790
+YWS+ G+ S I A MDG+SV ++F + + + +D E + +YWA V+E
Sbjct: 1885 LYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIE 1944
Query: 791 FAFLNGTGRQTLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYI 850
++GT R L + P+ +A+ + +Y+ D I++ K G+N+ +R ++ +
Sbjct: 1945 RGNVDGTDRMILVHQLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNL 2004
Query: 851 SDLKLYHRAKSM-GSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEP 909
L++YHR + SN C + C +CLP PG + + CAC ++LN DN +CS
Sbjct: 2005 RGLQVYHRRNAAESSNGCSNNMNACQQICLPVPGGL---FSCACATGFKLNPDNRSCSPY 2061
Query: 910 EEFLLFAQKNAVGRIMVANGECNDAYIPLTGL-KNVRAIEYDPVEKQLYWMDDDS----- 963
F++ + +A+ + + ++ +P+ G +N ++ D +YW D S
Sbjct: 2062 NSFIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASD 2121
Query: 964 HSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCA--DRDSINATSIDN 1021
++IRR+ G+ + +D + +Y+T A I I N
Sbjct: 2122 NAIRRIKPDGSSLMNIVTHGIGENGVR---GIAVDWVAGNLYFTNAFVSETLIEVLRI-N 2177
Query: 1022 NSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVG-RGAIMRANVDGTGRVELARADNAT-- 1078
+ V+++ +PRH+ RYL W D G R I R+ +D T R L T
Sbjct: 2178 TTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPR 2237
Query: 1079 ALALDQSAGTVYW 1091
LA+D+S G VYW
Sbjct: 2238 GLAVDRSDGYVYW 2250
Score = 301 bits (739), Expect = 9e-81
Identities = 183/589 (31%), Positives = 292/589 (49%), Gaps = 26/589 (4%)
Query: 340 VDFDPKTEYIYWADGLAKTISKARLDGSD-QSVVVRSSGVPDSIAIDPLSRKIYWTDPVM 398
V F + ++W D + + ++G + Q V+ S P+++A+D ++ KIY + +
Sbjct: 429 VAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKV 488
Query: 399 DTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEK--KPKIERANLDGSGR 456
+ I++ LDGSY +I L PR IA+ T G++F+SDW +PK+ERA +DGS R
Sbjct: 489 NRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNR 548
Query: 457 VLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKE-LHSNDII-HIFGXX 514
L+ KL WP + LD ++ ++YW D+R IE DG +RK +H +I H FG
Sbjct: 549 KDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVS 608
Query: 515 XXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFR-LGAPLGWNPCADDNG 573
K + + NK T + Q + GV + L P NPC D+NG
Sbjct: 609 LFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDNNG 668
Query: 574 GCSHLCF--NRPDD----YICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGRLSIK-NE 626
GC +C +R D+ + C C G +L D++ C+ + FL++S + I + +
Sbjct: 669 GCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQNFLIFSSQVAIRGIPFTLST 728
Query: 627 YNDAVIPIK-DLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKI-VEWLGLVEG 684
D ++P+ + + S +++SD I + ++G+ E + + VE
Sbjct: 729 QEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAANRVENVES 788
Query: 685 LAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSE-LG 743
LA DW +N+YWTD+ + I V RL +RR ++ Q L P+S+V+ P GY+++++
Sbjct: 789 LAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV-QYLNNPRSVVVHPFAGYLFFTDWFR 847
Query: 744 SKSIKRAAMDGSS-VSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTL 802
I RA DGS + V +G + LAID+ +YW +E + +G R+ L
Sbjct: 848 PAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRL 907
Query: 803 A--DNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHRAK 860
+ + P+ LA+F + +++ DW G I + RK DG IR + YI LK Y
Sbjct: 908 GHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNI 967
Query: 861 SMGSNQCGV---DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
GSN C NG CSH C P P R C CP RL +++TC
Sbjct: 968 QTGSNACNQPTHPNGDCSHFCFPVPNFQRV---CGCPYGMRLASNHLTC 1013
Score = 299 bits (735), Expect = 3e-80
Identities = 254/928 (27%), Positives = 430/928 (46%), Gaps = 76/928 (8%)
Query: 17 LEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPT-GIAIDWYT 75
++ G V+F + I W + E+ + +T + S +V P+ +A+DW +
Sbjct: 1777 IQNGLDVEFDDAEQYIYWVENPGEIHRV----KTDGTNRTVFASISMVGPSMNLALDWIS 1832
Query: 76 DKLYWTDGETNKIEVISIVQ--KYRKVLFWSE-----VDLARAIAVVPEDGLMFWTDWGE 128
LY T+ T IEV+++ +YRK L ++ V I V P G ++W+D G
Sbjct: 1833 RNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGT 1892
Query: 129 ---IP-KIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNG 184
+P KI A M+G K + N+ +T+D +YW ++ + +G
Sbjct: 1893 DSGVPAKIASANMDGTSV--KTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDG 1950
Query: 185 EKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIK 244
R +V L +P+ + + LY+TD Q I D A KI L + P ++
Sbjct: 1951 TDRMILVHQ-LSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIV-LRDNVPNLRGLQ 2008
Query: 245 VYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPG-YNCACPTGVKLR-ENSSTTCYDSP 302
VY S+ C N C +CL P P G ++CAC TG KL +N S + Y+S
Sbjct: 2009 VYHRRNAAESSNG--CSNNMNACQQICL--PVPGGLFSCACATGFKLNPDNRSCSPYNS- 2063
Query: 303 QMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRT-LTVDFDPKTEYIYWADGLAKTIS- 360
+VV+ S I SL+ D + +P+ R L VD D + +IYW D + S
Sbjct: 2064 --FIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASD 2121
Query: 361 ----KARLDGSDQSVVVRSSGVPDS----IAIDPLSRKIYWTDP-VMDT-INVARLDGSY 410
+ + DGS +V + G+ ++ IA+D ++ +Y+T+ V +T I V R++ +Y
Sbjct: 2122 NAIRRIKPDGSSLMNIV-THGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTY 2180
Query: 411 EKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSI 470
+V++ + PR I + ++FW+D+ ++ PKIER+ LD + R +L+SE + P +
Sbjct: 2181 RRVLLKVTVDMPRHIVVDPKNRYLFWADYGQR-PKIERSFLDCTNRTVLVSEGIVTPRGL 2239
Query: 471 ALDTVNNKLYWGDARTHKIEVCNMDGTERKEL-HSNDIIHIFGXXXXXXXXXXXXMQKRT 529
A+D + +YW D I ++G + + + + +G +
Sbjct: 2240 AVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKK 2299
Query: 530 LDRINKNTGLDRQPVV--EQMANMMGVKAF------RLGAPLGWNPCADDNGGCSHLCFN 581
+ + +K P V + + + V F R A + NPC ++NGGCSHLCF
Sbjct: 2300 IFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFA 2359
Query: 582 RPDDYI--CGCPLGLELTADKKTC-VEPEAFLVYSRKNIIGRLSIKNEYNDAVIPIKDLK 638
P + C C G L +D K C + E FL+++ N + L + E + +++
Sbjct: 2360 LPGLHTPKCDCAFGT-LQSDGKNCAISTENFLIFALSNSLRSLHLDPENHSPPFQTINVE 2418
Query: 639 EVSALALYVSGS-KLYWSDSKTKTINRCSVN--GSAVEK---IVEWLGLVEGLAIDWSGQ 692
Y S S ++Y++ + + + S S + I +G +G+A DW +
Sbjct: 2419 RTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITR 2478
Query: 693 NIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS-IKRAA 751
IY++D Q I DGS+R I + KP++IVLDP +GY+YW++ + + I+RA
Sbjct: 2479 RIYYSDYLNQMINSMAEDGSNRTVIA--RVPKPRAIVLDPCQGYLYWADWDTHAKIERAT 2536
Query: 752 MDGS-SVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPMPY 810
+ G+ V + + L +DYE +YW +E + L G R+ + + +
Sbjct: 2537 LGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAVHAF 2596
Query: 811 ALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLK----LYHRAKSMGSNQ 866
L L+ +YW D T +I +A K DGS + ++ +L +S + + K +N
Sbjct: 2597 GLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNL--LSQPRGINTVVKNQKQQCNNP 2654
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACP 894
C NGGCSH+C P P C CP
Sbjct: 2655 CEQFNGGCSHICAPGPNGA----ECQCP 2678
Score = 294 bits (722), Expect = 1e-78
Identities = 178/616 (28%), Positives = 310/616 (50%), Gaps = 32/616 (5%)
Query: 6 RLTRITTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVT 65
R RI +++ V FHY + W+D + ++ N E + E T
Sbjct: 412 RSFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVE---T 468
Query: 66 PTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTD 125
P +A+DW +K+Y + + N+I+++++ YR L + R IAV P G +F++D
Sbjct: 469 PENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSD 528
Query: 126 WGEI---PKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDF 182
W + PK+ERA M+G + RK +V+ + WP G+T+D + +YWVD++ +++ + +
Sbjct: 529 WESLSGEPKLERAFMDG--SNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTY 586
Query: 183 NGEKRKRVVKGG--LVYPFALTFSNDKLYWTDWQNWSIYTWD-IAANGPKIKELIKSHPV 239
+G +RK VV GG + +PF ++ ++++TDW ++ + P++ ++
Sbjct: 587 DGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQV--YYQASLR 644
Query: 240 PADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLS----PDPPGYNCACPTGVKLRENSS 295
P + VY RQ + PCK NN GC +C+LS D G+ C C G +L +
Sbjct: 645 PYGVTVYHSLRQPYATN--PCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQL-DTDE 701
Query: 296 TTCYDSPQMLLVVAQRSTISKISLDSPDFTPYTLPLK-DLKRTLTVDFDPKTEYIYWADG 354
C + Q L+ + + I I +P+ + + +DFD + I+++D
Sbjct: 702 RHCI-AVQNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDM 760
Query: 355 LAKTISKARLDGSDQSVVV--RSSGVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEK 412
I K ++DG+ + ++ R V +S+A D +S+ +YWTD +I+V RL +
Sbjct: 761 SKHMIFKQKIDGTGREILAANRVENV-ESLAFDWISKNLYWTDSHYKSISVMRLADKTRR 819
Query: 413 VIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIAL 472
++ L +PR++ +H AG++F++DW + KI RA DGS + +I+ L WPN +A+
Sbjct: 820 TVVQ-YLNNPRSVVVHPFAGYLFFTDW-FRPAKIMRAWSDGSHLLPVINTTLGWPNGLAI 877
Query: 473 DTVNNKLYWGDARTHKIEVCNMDGTERKEL-HSNDIIHIFGXXXXXXXXXXXXMQKRTLD 531
D ++LYW DA KIE DG +R+ L H + H FG + +
Sbjct: 878 DWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAII 937
Query: 532 RINKNTGLDRQPVVEQMANMMGVKAFRLGAPLGWNPC---ADDNGGCSHLCFNRPD-DYI 587
R+ K G + + +A ++ +K++ + G N C NG CSH CF P+ +
Sbjct: 938 RVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRV 997
Query: 588 CGCPLGLELTADKKTC 603
CGCP G+ L ++ TC
Sbjct: 998 CGCPYGMRLASNHLTC 1013
Score = 212 bits (517), Expect = 7e-54
Identities = 159/564 (28%), Positives = 267/564 (47%), Gaps = 37/564 (6%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTC----VEPEAFLVYSRKNIIGRLSIKNEYN 628
G CS C+N + C C G L +D +TC E LV S+ II S+ ++ +
Sbjct: 1398 GSCSQHCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKIIAD-SVTSQVH 1456
Query: 629 DAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVE-WLGLVEGLAI 687
+ +++ + A+ +++WSD+ NG+ + + + L E +AI
Sbjct: 1457 NIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAI 1516
Query: 688 DWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPK--KGYMYWSELG-S 744
DW G+N+YWTD + IEVS++DGS R +I + L P+ + LDP+ + ++WS+ G
Sbjct: 1517 DWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHH 1576
Query: 745 KSIKRAAMDGSSVSVFM-EQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNG-TGRQTL 802
I+RA+MDGS +V + +++ L IDY R +Y+ ++F NG RQ +
Sbjct: 1577 PRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVI 1636
Query: 803 ADN--IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHRAK 860
A + I PYAL LF DSVYW D T ++ +A K G N+ + ++ + + H +K
Sbjct: 1637 ASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSK 1696
Query: 861 SMGS-NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC-SEPEEFLLFAQK 918
S N C CSHLCL + Y C CP+ + L+ D + C + + FL+ ++
Sbjct: 1697 QPNSVNPCAFSR--CSHLCLLSSQGPHF-YSCVCPSGWSLSPDLLNCLRDDQPFLITVRQ 1753
Query: 919 NAV-GRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXX 977
+ + G + + NDA +P+ G++N +E+D E+ +YW+++ I RV
Sbjct: 1754 HIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPG-EIHRVKTD--GTN 1810
Query: 978 XXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNN---SSTGVIVRGDRM 1034
G S ++ LD + R +Y T SI ++ + T + G +
Sbjct: 1811 RTVFASISMVGPS--MNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTAL 1868
Query: 1035 ---LPRHLAFHQTKRYLIWNDVGRGA-----IMRANVDGTGRVEL--ARADNATALALDQ 1084
P + + L W+D G + I AN+DGT L ++ + LD
Sbjct: 1869 GVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDI 1928
Query: 1085 SAGTVYWAVSRQCDGQQDCEDGRD 1108
+YWAV+ + ++ DG D
Sbjct: 1929 EEQKLYWAVTGRGVIERGNVDGTD 1952
Score = 199 bits (485), Expect = 6e-50
Identities = 112/340 (32%), Positives = 176/340 (51%), Gaps = 20/340 (5%)
Query: 575 CSHLCFNRPDDYICGCPLGLELTADKKTCVEP---EAFLVYSRKNIIGRLSIKNEYNDAV 631
CS C N YIC C G D KTC + E +L++S + + L+I + +
Sbjct: 3163 CSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLI 3222
Query: 632 IPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEW-LGLVEGLAIDWS 690
+ + L V AL +LYW D++ + I R +N + E I+ L E LA+DW
Sbjct: 3223 L--EGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWV 3280
Query: 691 GQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLK--------KPKSIVLDPKKGYMYWSEL 742
+ +YW D + VS L+G RR + + P+ + L P+ GY+YW++
Sbjct: 3281 SRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADW 3340
Query: 743 GSKS-IKRAAMDGSSVSVFME-QVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQ 800
G ++ I R MDG++ SV + ++ + + IDY +YWA +E++ L G R
Sbjct: 3341 GHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRH 3400
Query: 801 TLADN-IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHRA 859
T+ D +P P+A+ +F D++YW DWNT +++ K DGSNR+++ D+ +YH
Sbjct: 3401 TVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPY 3460
Query: 860 KS-MGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYR 898
+ + SN CG +NGGCSHLCL PG + C CP +R
Sbjct: 3461 RQPIVSNPCGTNNGGCSHLCLIKPGG--KGFTCECPDDFR 3498
Score = 192 bits (468), Expect = 6e-48
Identities = 103/295 (34%), Positives = 154/295 (52%), Gaps = 17/295 (5%)
Query: 13 IAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAID 72
I + L+ A+DF + + W D + ++I+ M N+T K I++ L +A+D
Sbjct: 3222 ILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKT---NKETIINHRLPAAESLAVD 3278
Query: 73 WYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDL--------ARAIAVVPEDGLMFWT 124
W + KLYW D + + V + +R++L VD R +A+ P+ G ++W
Sbjct: 3279 WVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWA 3338
Query: 125 DWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNG 184
DWG I R GM+G + VI+ + WPNGIT+DY N L+YW DA L +++ D G
Sbjct: 3339 DWGHRAYIGRVGMDG--TNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEG 3396
Query: 185 EKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIK 244
R V G L +PFA+T D +YWTDW ++ + +G + L+ + P DI
Sbjct: 3397 HHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGN-KYDGSNRQTLVNTTHRPFDIH 3455
Query: 245 VYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVK-LRENSSTTC 298
VY RQ I + PC NN GCSHLCL+ P G+ C CP + L+ + ST C
Sbjct: 3456 VYHPYRQPIVSN--PCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYC 3508
Score = 176 bits (428), Expect = 4e-43
Identities = 91/237 (38%), Positives = 139/237 (58%), Gaps = 11/237 (4%)
Query: 63 LVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMF 122
++ P GIA+DW +YW+D + +IEV + +YRK L +++D AIAV P+ GLMF
Sbjct: 4141 VMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMF 4200
Query: 123 WTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDY-NNSLIYWVDAKLQFVDVID 181
WTDWG+ PK+E A MNG+ R ++V +++ WP G+++DY NN IYW D K ++ I
Sbjct: 4201 WTDWGKEPKLESAWMNGE--DRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIK 4258
Query: 182 FNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPA 241
++G R RV+ + P++L D+LYW + ++ + G K K L+ +P
Sbjct: 4259 YDGTDR-RVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLV-VNPWLT 4316
Query: 242 DIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTC 298
++++ + R S + CK+ CSHLCLL P GY+CACP G E S+T C
Sbjct: 4317 QVRIFHQLRYNKSVPNL-CKQI---CSHLCLLRPG--GYSCACPQGSSFIEGSTTEC 4367
Score = 172 bits (418), Expect = 7e-42
Identities = 97/326 (29%), Positives = 164/326 (50%), Gaps = 19/326 (5%)
Query: 280 YNCACPTGVKLRENSSTTCYDSPQM--LLVVAQRSTISKISLDSPDFTPYTLPLKDLKRT 337
Y C C G LRE TC + + L+ + R + +++D Y+L L+ L
Sbjct: 3174 YICKCAPGY-LREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYF---YSLILEGLDNV 3229
Query: 338 LTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSS-GVPDSIAIDPLSRKIYWTDP 396
+ +DFD + +YW D + I + L+ +++ ++ +S+A+D +SRK+YW D
Sbjct: 3230 VALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDA 3289
Query: 397 VMDTINVARLDGSYEKVII-------HTELYD-PRAIALHLTAGWMFWSDWNEKKPKIER 448
+D + V+ L+G + +++ +T +D PR +ALH G+++W+DW + I R
Sbjct: 3290 RLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRA-YIGR 3348
Query: 449 ANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDII 508
+DG+ + ++IS KL WPN I +D N+ LYW DA IE +++G R ++ +
Sbjct: 3349 VGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALP 3408
Query: 509 HIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFR-LGAPLGWNP 567
H F RT+++ NK G +RQ +V + + P+ NP
Sbjct: 3409 HPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNP 3468
Query: 568 CADDNGGCSHLCFNRP--DDYICGCP 591
C +NGGCSHLC +P + C CP
Sbjct: 3469 CGTNNGGCSHLCLIKPGGKGFTCECP 3494
Score = 167 bits (406), Expect = 2e-40
Identities = 135/565 (23%), Positives = 247/565 (43%), Gaps = 36/565 (6%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTCVEP---EAFLVYS--RKNIIGRLSIKNEY 627
G C C +RP ++C C G L + EA +++S R +IG I
Sbjct: 356 GICDQKCESRPGRHLCHCEEGYILERGQYCKANDSFGEASIIFSNGRDLLIG--DIHGRS 413
Query: 628 NDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEW-LGLVEGLA 686
++ ++ +A + +++W+D+ + +NG +++++ + E LA
Sbjct: 414 FRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLA 473
Query: 687 IDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMY---WSEL- 742
+DW IY +T RI++ LDGS R +I + L P+ I +DP GY++ W L
Sbjct: 474 VDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLS 533
Query: 743 GSKSIKRAAMDGSSVSVFME-QVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQT 801
G ++RA MDGS+ ++ ++G + +D + +YW +E +G R+T
Sbjct: 534 GEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKT 593
Query: 802 LADN---IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHR 858
+ IP P+ ++LF V++ DW + +A K +N + + + +YH
Sbjct: 594 VVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHS 653
Query: 859 AKS-MGSNQCGVDNGGCSHLCLPTPGDVRTD-----YRCACPAHYRLNKDNITCSEPEEF 912
+ +N C +NGGC +C+ + RTD +RC C ++L+ D C + F
Sbjct: 654 LRQPYATNPCKDNNGGCEQVCVLSH---RTDNDGLGFRCKCTFGFQLDTDERHCIAVQNF 710
Query: 913 LLFAQKNAVGRIMVANGECNDAYIPLTGLKN-VRAIEYDPVEKQLYWMDDDSHSIRRVPI 971
L+F+ + A+ I D +P++G + I++D + +++ D H I + I
Sbjct: 711 LIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKI 770
Query: 972 SYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRG 1031
+ + D + + +YWT + SI+ + + + V+
Sbjct: 771 D-----GTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVVQYL 825
Query: 1032 DRMLPRHLAFHQTKRYLIWNDVGRGA-IMRANVDGTGRVELARADNA--TALALDQSAGT 1088
+ PR + H YL + D R A IMRA DG+ + + LA+D +A
Sbjct: 826 NN--PRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASR 883
Query: 1089 VYWAVSRQCDGQQDCEDGRDEAECG 1113
+YW + + DG D G
Sbjct: 884 LYWVDAYFDKIEHSTFDGLDRRRLG 908
Score = 134 bits (323), Expect = 2e-30
Identities = 101/354 (28%), Positives = 173/354 (48%), Gaps = 33/354 (9%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADK--KTCV-EPEAFLVYSRKNI-IGRL 621
N C + G C C N Y C C G +D+ K C E + L+ N+ I +
Sbjct: 4009 NEC-EQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKY 4067
Query: 622 SIKNE----------YNDAVIPIKDLKEVSALALY--VSGSKLYWSDSKTKTI-NRCSVN 668
++ +E Y AV D +++ +Y V G + K I N S
Sbjct: 4068 NLSSERFSEYLQDEEYIQAVDYDWDPEDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGR 4127
Query: 669 GSAVEKI---VEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKP 725
+ V+++ ++++ +G+A+DW G++IYW+D +RIEV++LDG R+ +I L +P
Sbjct: 4128 NNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQP 4187
Query: 726 KSIVLDPKKGYMYWSELGSK-SIKRAAMDGSSVSVFM-EQVGRVHALAIDY-ERRAIYWA 782
+I ++PK G M+W++ G + ++ A M+G ++ + E +G L+IDY IYW+
Sbjct: 4188 AAIAVNPKLGLMFWTDWGKEPKLESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWS 4247
Query: 783 ALDPPVVEFAFLNGTGRQTLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKS 842
V+E +GT R+ +A PY+L +F D +YW G++ + K ++
Sbjct: 4248 DFKEDVIETIKYDGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEK 4307
Query: 843 IRKDLDYISDLKLYHRAKSMGS--NQCGVDNGGCSHLCLPTPGDVRTDYRCACP 894
+++ ++++H+ + S N C CSHLCL PG Y CACP
Sbjct: 4308 TLVVNPWLTQVRIFHQLRYNKSVPNLC---KQICSHLCLLRPG----GYSCACP 4354
Score = 132 bits (320), Expect = 5e-30
Identities = 98/335 (29%), Positives = 159/335 (47%), Gaps = 27/335 (8%)
Query: 280 YNCACPTG-VKLRENSSTTCY-DSPQMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRT 337
Y C C G + + C + LL++ I K +L S F+ Y L ++ +
Sbjct: 4028 YECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEY-LQDEEYIQA 4086
Query: 338 LTVDFDPKT---EYIYWA---DGLA-KTISKARLDGSD-------QSVVVRSSGV--PDS 381
+ D+DP+ +Y+ +G I +A + + Q V ++ V PD
Sbjct: 4087 VDYDWDPEDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDG 4146
Query: 382 IAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNE 441
IA+D + R IYW+D I VA+LDG Y K +I T+L P AIA++ G MFW+DW
Sbjct: 4147 IAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWG- 4205
Query: 442 KKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNN-KLYWGDARTHKIEVCNMDGTERK 500
K+PK+E A ++G R +L+ E L WP +++D +NN ++YW D + IE DGT+R+
Sbjct: 4206 KEPKLESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRR 4265
Query: 501 ELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFRLG 560
+ + + ++ + +K + + NK ++ + + V+ F
Sbjct: 4266 VI-AKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFH-- 4322
Query: 561 APLGWNPCADD--NGGCSHLCFNRPDDYICGCPLG 593
L +N + CSHLC RP Y C CP G
Sbjct: 4323 -QLRYNKSVPNLCKQICSHLCLLRPGGYSCACPQG 4356
Score = 77.0 bits (181), Expect = 4e-13
Identities = 69/245 (28%), Positives = 109/245 (44%), Gaps = 13/245 (5%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQ--MLLVVAQRSTISKI 317
C N GC+H C+ +P G C CP G L N S TC D + +L +Q +
Sbjct: 1353 CSDFNGGCTHECV--QEPFGAKCLCPLGF-LLANDSKTCEDIDECDILGSCSQHCYNMRG 1409
Query: 318 SLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSG 377
S T Y L+ RT V + + S + S+V S
Sbjct: 1410 SFRCSCDTGYM--LESDGRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSLVENGSY 1467
Query: 378 VPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWS 437
+ ++ D +S +I+W+D A +G+ +V+ + + IA+ ++W+
Sbjct: 1468 IV-AVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWT 1526
Query: 438 DWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNK--LYWGDARTH-KIEVCNM 494
D+ IE + +DGS R +LIS+ LT P +ALD N+ L+W D H +IE +M
Sbjct: 1527 DY--ALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASM 1584
Query: 495 DGTER 499
DG+ R
Sbjct: 1585 DGSMR 1589
Score = 70.5 bits (165), Expect = 3e-11
Identities = 68/263 (25%), Positives = 116/263 (44%), Gaps = 22/263 (8%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE-PEAFLVYSRK----NIIG- 619
N C+D NGGC+H C P C CPLG L D KTC + E ++ S N+ G
Sbjct: 1351 NSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRGS 1410
Query: 620 -RLSIKNEY--NDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIV 676
R S Y K S L L S +K+ +DS T ++ + +V
Sbjct: 1411 FRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKII-ADSVTSQVHN-------IYSLV 1462
Query: 677 EWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGY 736
E + + D I+W+D T + + +G+ RR + + ++I +D
Sbjct: 1463 ENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRN 1522
Query: 737 MYWSELGSKSIKRAAMDGSSVSVFM-EQVGRVHALAID--YERRAIYWAAL-DPPVVEFA 792
+YW++ ++I+ + +DGS +V + + + LA+D ++W+ P +E A
Sbjct: 1523 LYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERA 1582
Query: 793 FLNGTGRQTLA-DNIPMPYALAL 814
++G+ R + D I P L +
Sbjct: 1583 SMDGSMRTVIVQDKIFWPCGLTI 1605
Score = 67.3 bits (157), Expect = 3e-10
Identities = 71/301 (23%), Positives = 127/301 (42%), Gaps = 29/301 (9%)
Query: 564 GWNPCADDN-GGCSHLCFNRPDDYICGCPLGLELTADKKTCVE----PEAFLVYSRK--N 616
G N C D + GC H C + + C C G +L +DK+TCV+ E V S+K N
Sbjct: 3110 GINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCEN 3169
Query: 617 IIGRLSIKNEYNDAVIPI-KDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKI 675
+IG K P K ++ S + Y+ S Y+ + +++G I
Sbjct: 3170 VIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYY-------LRNLTIDGYFYSLI 3222
Query: 676 VEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKG 735
+E L V L D + +YW DT Q IE L+ +++ II L +S+ +D
Sbjct: 3223 LEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSR 3282
Query: 736 YMYWSELGSKSIKRAAMDGSSVSVFMEQ---------VGRVHALAIDYERRAIYWAAL-D 785
+YW + + + ++G + + LA+ + +YWA
Sbjct: 3283 KLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGH 3342
Query: 786 PPVVEFAFLNGTGRQT-LADNIPMPYALAL--FNDSVYWGDWNTGQIQQARKTDGSNRKS 842
+ ++GT + ++ + P + + ND +YW D + G I+ + +G +R +
Sbjct: 3343 RAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYS-DLEGHHRHT 3401
Query: 843 I 843
+
Sbjct: 3402 V 3402
Score = 66.9 bits (156), Expect = 4e-10
Identities = 64/249 (25%), Positives = 103/249 (41%), Gaps = 24/249 (9%)
Query: 860 KSMGSNQCGVDNGGCSHL---CLPTPGDVRTDYRCACPAHYRLNKDNITC---SEPEEFL 913
K M + VD C+ + C +V Y C C Y D TC S E +L
Sbjct: 3142 KLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYL 3201
Query: 914 LFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISY 973
+F+ + + R + +G + L GL NV A+++D VEK+LYW+D I R+ ++
Sbjct: 3202 IFSNRYYL-RNLTIDGYFYS--LILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLN- 3257
Query: 974 XXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGV---IVR 1030
L + +D + R +YW A D + + ++ + V
Sbjct: 3258 ----KTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVD 3313
Query: 1031 GDRML----PRHLAFHQTKRYLIWNDVG-RGAIMRANVDGTGR--VELARADNATALALD 1083
+ PR LA H YL W D G R I R +DGT + + + + + +D
Sbjct: 3314 ANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITID 3373
Query: 1084 QSAGTVYWA 1092
+ +YWA
Sbjct: 3374 YTNDLLYWA 3382
Score = 66.5 bits (155), Expect = 5e-10
Identities = 65/249 (26%), Positives = 95/249 (38%), Gaps = 27/249 (10%)
Query: 945 RAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTM 1004
RAI DP + LYW D D+H+ I L P + LD +
Sbjct: 2510 RAIVLDPCQGYLYWADWDTHA----KIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLL 2565
Query: 1005 YWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTK-----RYLIWNDVGRGAIM 1059
YW A I +++ TGV DR + + A H +Y+ W D+ I
Sbjct: 2566 YWVDASLQRIERSTL-----TGV----DREVIVNAAVHAFGLTLYGQYIYWTDLYTQRIY 2616
Query: 1060 RAN-VDGTGRVELARADNATALALDQSAGTVYWAVSRQCDGQQDCEDGRDEAEC--GACG 1116
RAN DG+G++ + L+ + TV +QC+ + +G C G G
Sbjct: 2617 RANKYDGSGQIAMT----TNLLSQPRGINTVVKNQKQQCNNPCEQFNGGCSHICAPGPNG 2672
Query: 1117 GDVRCA-DGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDEA 1175
+ +C +G +F C G CI+ + CD C DGSDE
Sbjct: 2673 AECQCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGRCISEEWKCDNDNDCGDGSDEM 2732
Query: 1176 PAACAYGHT 1184
+ CA HT
Sbjct: 2733 ESVCAL-HT 2740
Score = 53.2 bits (122), Expect = 5e-06
Identities = 42/190 (22%), Positives = 82/190 (43%), Gaps = 13/190 (6%)
Query: 35 SDQKPELIQCMNY---NETYTGEKFKIVSEGLVTPTGIAIDWYTDKLYWTDGETNKIEVI 91
S+ +P LI Y N T G + ++ EGL + D +LYW D + IE +
Sbjct: 3195 SNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERM 3254
Query: 92 SIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERAGMNGD---PATRKVIV 148
+ + ++ + + A ++AV ++W D + + + +NG + +
Sbjct: 3255 FLNKTNKETIINHRLPAAESLAVDWVSRKLYWLD-ARLDGLFVSDLNGGHRRMLAQHCVD 3313
Query: 149 RDNIFW---PNGITVDYNNSLIYWVD-AKLQFVDVIDFNGEKRKRVVKGGLVYPFALT-- 202
+N F P G+ + +YW D ++ + +G + ++ L +P +T
Sbjct: 3314 ANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITID 3373
Query: 203 FSNDKLYWTD 212
++ND LYW D
Sbjct: 3374 YTNDLLYWAD 3383
Score = 48.8 bits (111), Expect = 1e-04
Identities = 37/118 (31%), Positives = 44/118 (37%), Gaps = 23/118 (19%)
Query: 1097 CDGQQDCEDGRDEAEC--GACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDA------- 1147
CDG +DC DG DE C +CA G +A
Sbjct: 1168 CDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPP 1227
Query: 1148 -------FRCDE-GLCIAARFVCDGRPQCADGSDE----APAAC--AYGHTDQVNGIH 1191
F+C E G+CI + CDG P C GSDE P C +Y H D N IH
Sbjct: 1228 GMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIH 1285
Score = 43.2 bits (97), Expect = 0.006
Identities = 62/276 (22%), Positives = 101/276 (36%), Gaps = 35/276 (12%)
Query: 834 KTDGSNRKSIRKDLDYISDLKLYHRAKSMGSNQCGVDN-GGCSHLCLPTPGDVRTDYRCA 892
K D + K +++ D K G N+C + GC H C D T + C+
Sbjct: 3081 KCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISGCDHNCT----DTLTSFYCS 3136
Query: 893 CPAHYRLNKDNITCSEPEEF----LLFAQK--NAVGRIMVANGECNDAYIPLTGLKNVRA 946
C Y+L D TC + +E + +QK N +G + +C Y+ K R
Sbjct: 3137 CRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYIC---KCAPGYLREPDGKTCR- 3192
Query: 947 IEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYW 1006
+ +E Y + + + +R + I GL + D + + +YW
Sbjct: 3193 -QNSNIEP--YLIFSNRYYLRNLTID------GYFYSLILEGLDNVVALDFDRVEKRLYW 3243
Query: 1007 TCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGAIMRANVDGT 1066
R I + N ++ I+ LA R L W D + ++++G
Sbjct: 3244 IDTQRQVIERMFL-NKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGG 3302
Query: 1067 GRVELAR----------ADNATALALDQSAGTVYWA 1092
R LA+ DN LAL G +YWA
Sbjct: 3303 HRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWA 3338
Score = 42.7 bits (96), Expect = 0.008
Identities = 28/92 (30%), Positives = 51/92 (55%), Gaps = 7/92 (7%)
Query: 13 IAKDLEQGTAVDFHYRKNLICWSD--QKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIA 70
I+ DL+Q A+ + + L+ W+D ++P+L E ++ +V E L PTG++
Sbjct: 4180 ISTDLDQPAAIAVNPKLGLMFWTDWGKEPKLESAWMNGE----DRNILVFEDLGWPTGLS 4235
Query: 71 IDWY-TDKLYWTDGETNKIEVISIVQKYRKVL 101
ID+ D++YW+D + + IE I R+V+
Sbjct: 4236 IDYLNNDRIYWSDFKEDVIETIKYDGTDRRVI 4267
Score = 42.3 bits (95), Expect = 0.010
Identities = 38/130 (29%), Positives = 46/130 (35%), Gaps = 20/130 (15%)
Query: 1063 VDGTGRVELARADNATALALDQSAGTVYWAVSRQCDGQQDCEDGRDEAEC-----GACGG 1117
VDG+ V N TA ++G V+ +CDG DC D DEA C G C
Sbjct: 1175 VDGSDEVGCVL--NCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHS 1232
Query: 1118 D-VRC------------ADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDG 1164
D +C DG F CD G CI ++CD
Sbjct: 1233 DEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLCDR 1292
Query: 1165 RPQCADGSDE 1174
C D SDE
Sbjct: 1293 DNDCGDMSDE 1302
Score = 41.5 bits (93), Expect = 0.018
Identities = 31/89 (34%), Positives = 34/89 (38%), Gaps = 30/89 (33%)
Query: 1097 CDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCI 1156
CDG DC D DE CG C+ AF C G CI
Sbjct: 1045 CDGVDDCHDNSDEQLCGTLNNT--CSSS----------------------AFTCGHGECI 1080
Query: 1157 AARFVCDGRPQCADGSDE------APAAC 1179
A + CD R C DGSDE APA+C
Sbjct: 1081 PAHWRCDKRNDCVDGSDEHNCPTHAPASC 1109
Score = 41.5 bits (93), Expect = 0.018
Identities = 29/108 (26%), Positives = 39/108 (36%), Gaps = 9/108 (8%)
Query: 1068 RVELARADNATALALDQSAGTVYWAVSRQCDGQQ-DCEDGRDEAECGACGGDVRCADGTX 1126
RV L DN D S + + C + C GR + C + C D +
Sbjct: 2838 RVYLCDGDNDCG---DNSDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASD 2894
Query: 1127 XXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
D F+CD G CI + ++CDG C D SDE
Sbjct: 2895 EPASCGHSERTCLA-----DEFKCDGGRCIPSEWICDGDNDCGDMSDE 2937
Score = 41.5 bits (93), Expect = 0.018
Identities = 39/153 (25%), Positives = 75/153 (49%), Gaps = 13/153 (8%)
Query: 20 GTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAIDWYTDKLY 79
G AVD+ R I WSD K + I+ + Y K+ ++S L P IA++ ++
Sbjct: 4146 GIAVDWVGRH--IYWSDVKNKRIEVAKLDGRY--RKW-LISTDLDQPAAIAVNPKLGLMF 4200
Query: 80 WTD-GETNKIEVISIVQKYRKVLFWSEVDLARAIAV-VPEDGLMFWTDWGEIPKIERAGM 137
WTD G+ K+E + + R +L + ++ +++ + ++W+D+ E IE
Sbjct: 4201 WTDWGKEPKLESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKE-DVIETIKY 4259
Query: 138 NGDPATRKVIVRDNIFWPNGITVDYNNSLIYWV 170
+G R+VI ++ + N ++D +YW+
Sbjct: 4260 DG--TDRRVIAKEAM---NPYSLDIFEDQLYWI 4287
Score = 41.1 bits (92), Expect = 0.023
Identities = 31/90 (34%), Positives = 36/90 (40%), Gaps = 27/90 (30%)
Query: 1090 YWAVSRQCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFR 1149
YW +CDG DC DG DE E C DV C + FR
Sbjct: 3858 YW----KCDGDDDCGDGSDE-ELHLCL-DVPC---------------------NSPNRFR 3890
Query: 1150 CDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
CD CI + VC+G C DG+DE C
Sbjct: 3891 CDNNRCIYSHEVCNGVDDCGDGTDETEEHC 3920
Score = 40.7 bits (91), Expect = 0.031
Identities = 27/93 (29%), Positives = 33/93 (35%), Gaps = 13/93 (13%)
Query: 1096 QCDGQQDCEDGRDEAECGA--CG-GDVRCADGTXXXXX----------XXXXXXXXXXXX 1142
QCDGQ DC D DE C C + RC +
Sbjct: 3738 QCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRT 3797
Query: 1143 XXXDAFRCDEGLCIAARFVCDGRPQCADGSDEA 1175
+ F+C G C+ + CDG C D SDEA
Sbjct: 3798 CHPEYFQCTSGHCVHSELKCDGSADCLDASDEA 3830
Score = 39.9 bits (89), Expect = 0.054
Identities = 27/84 (32%), Positives = 31/84 (36%), Gaps = 21/84 (25%)
Query: 1096 QCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLC 1155
+CDG DC D DEA+C R DG F C +C
Sbjct: 3816 KCDGSADCLDASDEADC-----PTRFPDGAYCQATM----------------FECKNHVC 3854
Query: 1156 IAARFVCDGRPQCADGSDEAPAAC 1179
I + CDG C DGSDE C
Sbjct: 3855 IPPYWKCDGDDDCGDGSDEELHLC 3878
Score = 39.5 bits (88), Expect = 0.071
Identities = 29/97 (29%), Positives = 36/97 (37%), Gaps = 14/97 (14%)
Query: 1096 QCDGQQDCEDGRDEAECG--ACGGDVRCADGTXXXXXXX---------XXXXXXXXXXXX 1144
+CD +DC DG DE +C C + C +G
Sbjct: 126 RCDHVRDCPDGADENDCQYPTCE-QLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEICL 184
Query: 1145 XDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAACAY 1181
+ F C G CI +VCD C DGSDE AC Y
Sbjct: 185 HNEFSCGNGECIPRAYVCDHDNDCQDGSDE--HACNY 219
Score = 39.5 bits (88), Expect = 0.071
Identities = 16/32 (50%), Positives = 17/32 (53%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F C G CI+ FVCD C DGSDE C
Sbjct: 3037 FTCQNGRCISKTFVCDEDNDCGDGSDELMHLC 3068
Score = 39.1 bits (87), Expect = 0.094
Identities = 23/73 (31%), Positives = 28/73 (38%), Gaps = 6/73 (8%)
Query: 1103 CEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVC 1162
C +GR +E C D C DG+ AF C G C+ + C
Sbjct: 2707 CSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPT------AFTCANGRCVQYSYRC 2760
Query: 1163 DGRPQCADGSDEA 1175
D C DGSDEA
Sbjct: 2761 DYYNDCGDGSDEA 2773
Score = 38.7 bits (86), Expect = 0.12
Identities = 17/47 (36%), Positives = 24/47 (51%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
N C NGGC+H C+ P +C CP + L D+ TC + +E
Sbjct: 1351 NSCSDFNGGCTHECVQEPFGA----KCLCPLGFLLANDSKTCEDIDE 1393
Score = 37.9 bits (84), Expect = 0.22
Identities = 23/77 (29%), Positives = 29/77 (37%), Gaps = 7/77 (9%)
Query: 1098 DGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIA 1157
D Q C++ + ++ C D C DG+ F C CI
Sbjct: 1111 DTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQ-------FNCPNHRCID 1163
Query: 1158 ARFVCDGRPQCADGSDE 1174
FVCDG C DGSDE
Sbjct: 1164 LSFVCDGDKDCVDGSDE 1180
Score = 37.9 bits (84), Expect = 0.22
Identities = 30/101 (29%), Positives = 38/101 (37%), Gaps = 16/101 (15%)
Query: 1096 QCDGQQDCEDGRDE-AECGA--CG-GDVRCADGTXXXXXXXXXXXXXXXXXXXXD----- 1146
+CDGQ+DC DG DE A C C G +C+DG D
Sbjct: 3531 KCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCE 3590
Query: 1147 -------AFRCDEGLCIAARFVCDGRPQCADGSDEAPAACA 1180
++C CI + CD C D SDE + CA
Sbjct: 3591 NHHCDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSSHCA 3631
Score = 37.9 bits (84), Expect = 0.22
Identities = 14/38 (36%), Positives = 20/38 (52%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAACAYGHTD 1185
F+C +G C + + +C+ C DGSDE C H D
Sbjct: 3558 FQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCD 3595
Score = 37.5 bits (83), Expect = 0.29
Identities = 26/93 (27%), Positives = 32/93 (34%), Gaps = 12/93 (12%)
Query: 1094 SRQCDGQQDCEDGRDEAECGA-C-GGDVRCADGTXXXXXXXXXXXXXXXXXXXXDA---- 1147
S++CD + DC D DE C C + C +G A
Sbjct: 161 SQKCDWKVDCRDSSDEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYP 220
Query: 1148 ------FRCDEGLCIAARFVCDGRPQCADGSDE 1174
F C G CI +VCDG C D DE
Sbjct: 221 TCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDE 253
Score = 37.5 bits (83), Expect = 0.29
Identities = 19/44 (43%), Positives = 21/44 (47%), Gaps = 3/44 (6%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDE---APAACAYGHTDQVN 1188
FRC CI R+ CDG+ C D SDE AP C VN
Sbjct: 3725 FRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVN 3768
Score = 37.1 bits (82), Expect = 0.38
Identities = 17/39 (43%), Positives = 21/39 (53%), Gaps = 3/39 (7%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDE---APAACAYGH 1183
FRC G CI A + CDG C+D +DE A C G+
Sbjct: 33 FRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGY 71
Score = 36.3 bits (80), Expect = 0.66
Identities = 23/90 (25%), Positives = 33/90 (36%), Gaps = 4/90 (4%)
Query: 1100 QQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAAR 1159
Q C++GR ++ C D C DG+ F+CD G CI
Sbjct: 3036 QFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHE----FKCDNGRCIEMM 3091
Query: 1160 FVCDGRPQCADGSDEAPAACAYGHTDQVNG 1189
+C+ C D SDE H ++G
Sbjct: 3092 KLCNHLDDCLDNSDEKGCGINECHDPSISG 3121
Score = 35.9 bits (79), Expect = 0.87
Identities = 25/76 (32%), Positives = 30/76 (39%), Gaps = 4/76 (5%)
Query: 1101 QDCEDGRDEAECGAC-GGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCD-EGLCIAA 1158
Q+C+ G C D RC DGT F+C EG CI +
Sbjct: 26 QECDSAHFRCGSGHCIPADWRC-DGTKDCSDDADEIGCAVVTCQQG-YFKCQSEGQCIPS 83
Query: 1159 RFVCDGRPQCADGSDE 1174
+VCD C DGSDE
Sbjct: 84 SWVCDQDQDCDDGSDE 99
Score = 35.9 bits (79), Expect = 0.87
Identities = 25/77 (32%), Positives = 27/77 (35%), Gaps = 9/77 (11%)
Query: 1105 DGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDG 1164
D R + C GDV C DG + F C GLCI F CD
Sbjct: 2962 DRRCIPQSWVCDGDVDCTDG-------YDENQNCTRRTCSENEFTCGYGLCIPKIFRCDR 3014
Query: 1165 RPQCADGSDEAPAACAY 1181
C D SDE C Y
Sbjct: 3015 HNDCGDYSDE--RGCLY 3029
Score = 33.9 bits (74), Expect = 3.5
Identities = 12/29 (41%), Positives = 16/29 (55%)
Query: 1151 DEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
+ +CI ++CDG C D SDE P C
Sbjct: 2831 NSNICIPRVYLCDGDNDCGDNSDENPTYC 2859
Score = 33.5 bits (73), Expect = 4.7
Identities = 12/28 (42%), Positives = 16/28 (57%)
Query: 1147 AFRCDEGLCIAARFVCDGRPQCADGSDE 1174
+F C G C+ ++CDG C D SDE
Sbjct: 1030 SFPCKNGRCVPNYYLCDGVDDCHDNSDE 1057
Score = 33.1 bits (72), Expect = 6.2
Identities = 17/54 (31%), Positives = 25/54 (46%)
Query: 1039 LAFHQTKRYLIWNDVGRGAIMRANVDGTGRVELARADNATALALDQSAGTVYWA 1092
+AF R + ++D I DG+ R +AR A+ LD G +YWA
Sbjct: 2471 IAFDWITRRIYYSDYLNQMINSMAEDGSNRTVIARVPKPRAIVLDPCQGYLYWA 2524
>AY265357-1|AAP88585.1| 4655|Homo sapiens glycoprotein receptor
gp330/megalin precursor protein.
Length = 4655
Score = 439 bits (1081), Expect = e-122
Identities = 322/1138 (28%), Positives = 545/1138 (47%), Gaps = 72/1138 (6%)
Query: 4 TSRLTRITTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGL 63
TS++ I ++ ++ AVDF I WSD Q ++ G ++V +
Sbjct: 1452 TSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDAT----QGKTWSAFQNGTDRRVVFDSS 1507
Query: 64 VTPTG-IAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPE--DGL 120
+ T IAIDW LYWTD IEV I +R VL + R +A+ P + L
Sbjct: 1508 IILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHL 1567
Query: 121 MFWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVI 180
+FW+DWG P+IERA M+G + R VIV+D IFWP G+T+DY N L+Y++D+ L ++D
Sbjct: 1568 LFWSDWGHHPRIERASMDG--SMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFC 1625
Query: 181 DFNGEKRKRVVKGGLV--YPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHP 238
D+NG R++V+ L+ +P+ALT D +YWTD + + +G ++ +
Sbjct: 1626 DYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRAN-KWHGGNQSVVMYNIQ 1684
Query: 239 VPADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPG-YNCACPTGVKLRENSSTT 297
P I S+Q S PC + CSHLCLLS P Y+C CP+G L +
Sbjct: 1685 WPLGIVAVHPSKQPNSVN--PCAFSR--CSHLCLLSSQGPHFYSCVCPSGWSLSPD-LLN 1739
Query: 298 CYDSPQMLLVVAQRSTISKISLD-SPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLA 356
C Q L+ ++ I ISL+ +P+ ++ L V+FD +YIYW +
Sbjct: 1740 CLRDDQPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPG 1799
Query: 357 KTISKARLDGSDQSVVVRSSGVPDS--IAIDPLSRKIYWTDPVMDTINVARLDGS--YEK 412
+ I + + DG++++V S V S +A+D +SR +Y T+P +I V L G Y K
Sbjct: 1800 E-IHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRK 1858
Query: 413 VIIHTE-----LYDPRAIALHLTAGWMFWSDWNEKK---PKIERANLDGSGRVLLISEKL 464
+I + + P I + G ++WSD KI AN+DG+ L + L
Sbjct: 1859 TLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNL 1918
Query: 465 TWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXXXXXXXXXX 524
+ LD KLYW IE N+DGT+R L + + H +G
Sbjct: 1919 EHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMIL-VHQLSHPWGIAVHDSFLYYTD 1977
Query: 525 MQKRTLDRINKNTGLDRQPVVEQMANMMGVKAF-RLGAPLGWNPCADDNGGCSHLCFNRP 583
Q ++R++K TG ++ + + + N+ G++ + R A N C+++ C +C P
Sbjct: 1978 EQYEVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNNMNACQQICLPVP 2037
Query: 584 DD-YICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGRLSIK-NEYNDAVIPIKDL-KEV 640
+ C C G +L D ++C +F+V S + I S++ +++++ ++P+ +
Sbjct: 2038 GGLFSCACATGFKLNPDNRSCSPYNSFIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNA 2097
Query: 641 SALALYVSGSKLYWSD-----SKTKTINRCSVNGSAVEKIV-EWLGL--VEGLAIDWSGQ 692
+ + VS +YW D + I R +GS++ IV +G V G+A+DW
Sbjct: 2098 LHVDVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAG 2157
Query: 693 NIYWTDTTTQR--IEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSK-SIKR 749
N+Y+T+ IEV R++ + RR ++ + P+ IV+DPK Y++W++ G + I+R
Sbjct: 2158 NLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQRPKIER 2217
Query: 750 AAMDGSSVSVFM-EQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTL--ADNI 806
+ +D ++ +V + E + LA+D +YW ++ +NG + +
Sbjct: 2218 SFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRY 2277
Query: 807 PMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKS--IRKDLDYISDLKLYHR------ 858
P PY + +F +S+ W D N +I QA K + IR +++++ D+ ++ +
Sbjct: 2278 PTPYGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRS 2337
Query: 859 AKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS-EPEEFLLFAQ 917
+ +N C +NGGCSHLC PG + T +C C A L D C+ E FL+FA
Sbjct: 2338 PAEVNNNPCLENNGGCSHLCFALPG-LHTP-KCDC-AFGTLQSDGKNCAISTENFLIFAL 2394
Query: 918 KNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXX 977
N++ + + + + + + V +++YD V ++Y+ + + + + ISY
Sbjct: 2395 SNSLRSLHLDPENHSPPFQTINVERTVMSLDYDSVSDRIYFTQNLASGVGQ--ISYATLS 2452
Query: 978 XXXXX-XXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLP 1036
G+ + D + R +Y++ IN+ + D ++ T VI R + P
Sbjct: 2453 SGIHTPTVIASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNRT-VIARVPK--P 2509
Query: 1037 RHLAFHQTKRYLIWNDVGRGA-IMRANVDGTGRVELARAD--NATALALDQSAGTVYW 1091
R + + YL W D A I RA + G RV + + + L LD +YW
Sbjct: 2510 RAIVLDPCQGYLYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYW 2567
Score = 362 bits (890), Expect = 5e-99
Identities = 252/853 (29%), Positives = 424/853 (49%), Gaps = 54/853 (6%)
Query: 280 YNCACPTGVKLRENSSTTC--YDSPQMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRT 337
+ C+C TG L E+ TC S +LL+VA ++ I S+ S Y+L +++
Sbjct: 1411 FRCSCDTGYML-ESDGRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSL-VENGSYI 1468
Query: 338 LTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGV-PDSIAIDPLSRKIYWTDP 396
+ VDFD + I+W+D A +G+D+ VV SS + ++IAID + R +YWTD
Sbjct: 1469 VAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDY 1528
Query: 397 VMDTINVARLDGSYEKVIIHTELYDPRAIAL--HLTAGWMFWSDWNEKKPKIERANLDGS 454
++TI V+++DGS+ V+I L +PR +AL + +FWSDW P+IERA++DGS
Sbjct: 1529 ALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGH-HPRIERASMDGS 1587
Query: 455 GRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDII--HIFG 512
R +++ +K+ WP + +D N LY+ D+ ++ C+ +G R+++ ++D+I H +
Sbjct: 1588 MRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYA 1647
Query: 513 XXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFRLG-APLGWNPCADD 571
R + R NK G ++ V+ + +G+ A P NPCA
Sbjct: 1648 LTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFS 1707
Query: 572 NGGCSHLCF---NRPDDYICGCPLGLELTADKKTCV-EPEAFLVYSRKNIIGRLSIKNEY 627
CSHLC P Y C CP G L+ D C+ + + FL+ R++II +S+ E
Sbjct: 1708 R--CSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNCLRDDQPFLITVRQHIIFGISLNPEV 1765
Query: 628 --NDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGS--AVEKIVEWLGLVE 683
NDA++PI ++ + + +YW ++ + I+R +G+ V + +G
Sbjct: 1766 KSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPGE-IHRVKTDGTNRTVFASISMVGPSM 1824
Query: 684 GLAIDWSGQNIYWTDTTTQRIEVSRLDGS--SRRAIIWQ-----GLKKPKSIVLDPKKGY 736
LA+DW +N+Y T+ TQ IEV L G R+ +I G+ P I +DP +G
Sbjct: 1825 NLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGK 1884
Query: 737 MYWSELGSKS-----IKRAAMDGSSV-SVFMEQVGRVHALAIDYERRAIYWAALDPPVVE 790
+YWS+ G+ S I A MDG+SV ++F + + + +D E + +YWA V+E
Sbjct: 1885 LYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIE 1944
Query: 791 FAFLNGTGRQTLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYI 850
++GT R L + P+ +A+ + +Y+ D I++ K G+N+ +R ++ +
Sbjct: 1945 RGNVDGTDRMILVHQLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNL 2004
Query: 851 SDLKLYHRAKSM-GSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEP 909
L++YHR + SN C + C +CLP PG + + CAC ++LN DN +CS
Sbjct: 2005 RGLQVYHRRNAAESSNGCSNNMNACQQICLPVPGGL---FSCACATGFKLNPDNRSCSPY 2061
Query: 910 EEFLLFAQKNAVGRIMVANGECNDAYIPLTGL-KNVRAIEYDPVEKQLYWMDDDS----- 963
F++ + +A+ + + ++ +P+ G +N ++ D +YW D S
Sbjct: 2062 NSFIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASD 2121
Query: 964 HSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCA--DRDSINATSIDN 1021
++IRR+ G+ + +D + +Y+T A I I N
Sbjct: 2122 NAIRRIKPDGSSLMNIVTHGIGENGVR---GIAVDWVAGNLYFTNAFVSETLIEVLRI-N 2177
Query: 1022 NSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVG-RGAIMRANVDGTGRVELARADNAT-- 1078
+ V+++ +PRH+ RYL W D G R I R+ +D T R L T
Sbjct: 2178 TTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPR 2237
Query: 1079 ALALDQSAGTVYW 1091
LA+D+S G VYW
Sbjct: 2238 GLAVDRSDGYVYW 2250
Score = 301 bits (739), Expect = 9e-81
Identities = 183/589 (31%), Positives = 292/589 (49%), Gaps = 26/589 (4%)
Query: 340 VDFDPKTEYIYWADGLAKTISKARLDGSD-QSVVVRSSGVPDSIAIDPLSRKIYWTDPVM 398
V F + ++W D + + ++G + Q V+ S P+++A+D ++ KIY + +
Sbjct: 429 VAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKV 488
Query: 399 DTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEK--KPKIERANLDGSGR 456
+ I++ LDGSY +I L PR IA+ T G++F+SDW +PK+ERA +DGS R
Sbjct: 489 NRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNR 548
Query: 457 VLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKE-LHSNDII-HIFGXX 514
L+ KL WP + LD ++ ++YW D+R IE DG +RK +H +I H FG
Sbjct: 549 KDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVS 608
Query: 515 XXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFR-LGAPLGWNPCADDNG 573
K + + NK T + Q + GV + L P NPC D+NG
Sbjct: 609 LFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDNNG 668
Query: 574 GCSHLCF--NRPDD----YICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGRLSIK-NE 626
GC +C +R D+ + C C G +L D++ C+ + FL++S + I + +
Sbjct: 669 GCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQNFLIFSSQVAIRGIPFTLST 728
Query: 627 YNDAVIPIK-DLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKI-VEWLGLVEG 684
D ++P+ + + S +++SD I + ++G+ E + + VE
Sbjct: 729 QEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAANRVENVES 788
Query: 685 LAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSE-LG 743
LA DW +N+YWTD+ + I V RL +RR ++ Q L P+S+V+ P GY+++++
Sbjct: 789 LAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV-QYLNNPRSVVVHPFAGYLFFTDWFR 847
Query: 744 SKSIKRAAMDGSS-VSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTL 802
I RA DGS + V +G + LAID+ +YW +E + +G R+ L
Sbjct: 848 PAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRL 907
Query: 803 A--DNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHRAK 860
+ + P+ LA+F + +++ DW G I + RK DG IR + YI LK Y
Sbjct: 908 GHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNI 967
Query: 861 SMGSNQCGV---DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
GSN C NG CSH C P P R C CP RL +++TC
Sbjct: 968 QTGSNACNQPTHPNGDCSHFCFPVPNFQRV---CGCPYGMRLASNHLTC 1013
Score = 299 bits (735), Expect = 3e-80
Identities = 254/928 (27%), Positives = 430/928 (46%), Gaps = 76/928 (8%)
Query: 17 LEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPT-GIAIDWYT 75
++ G V+F + I W + E+ + +T + S +V P+ +A+DW +
Sbjct: 1777 IQNGLDVEFDDAEQYIYWVENPGEIHRV----KTDGTNRTVFASISMVGPSMNLALDWIS 1832
Query: 76 DKLYWTDGETNKIEVISIVQ--KYRKVLFWSE-----VDLARAIAVVPEDGLMFWTDWGE 128
LY T+ T IEV+++ +YRK L ++ V I V P G ++W+D G
Sbjct: 1833 RNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGT 1892
Query: 129 ---IP-KIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNG 184
+P KI A M+G K + N+ +T+D +YW ++ + +G
Sbjct: 1893 DSGVPAKIASANMDGTSV--KTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDG 1950
Query: 185 EKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIK 244
R +V L +P+ + + LY+TD Q I D A KI L + P ++
Sbjct: 1951 TDRMILVHQ-LSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIV-LRDNVPNLRGLQ 2008
Query: 245 VYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPG-YNCACPTGVKLR-ENSSTTCYDSP 302
VY S+ C N C +CL P P G ++CAC TG KL +N S + Y+S
Sbjct: 2009 VYHRRNAAESSNG--CSNNMNACQQICL--PVPGGLFSCACATGFKLNPDNRSCSPYNS- 2063
Query: 303 QMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRT-LTVDFDPKTEYIYWADGLAKTIS- 360
+VV+ S I SL+ D + +P+ R L VD D + +IYW D + S
Sbjct: 2064 --FIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASD 2121
Query: 361 ----KARLDGSDQSVVVRSSGVPDS----IAIDPLSRKIYWTDP-VMDT-INVARLDGSY 410
+ + DGS +V + G+ ++ IA+D ++ +Y+T+ V +T I V R++ +Y
Sbjct: 2122 NAIRRIKPDGSSLMNIV-THGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTY 2180
Query: 411 EKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSI 470
+V++ + PR I + ++FW+D+ ++ PKIER+ LD + R +L+SE + P +
Sbjct: 2181 RRVLLKVTVDMPRHIVVDPKNRYLFWADYGQR-PKIERSFLDCTNRTVLVSEGIVTPRGL 2239
Query: 471 ALDTVNNKLYWGDARTHKIEVCNMDGTERKEL-HSNDIIHIFGXXXXXXXXXXXXMQKRT 529
A+D + +YW D I ++G + + + + +G +
Sbjct: 2240 AVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKK 2299
Query: 530 LDRINKNTGLDRQPVV--EQMANMMGVKAF------RLGAPLGWNPCADDNGGCSHLCFN 581
+ + +K P V + + + V F R A + NPC ++NGGCSHLCF
Sbjct: 2300 IFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFA 2359
Query: 582 RPDDYI--CGCPLGLELTADKKTC-VEPEAFLVYSRKNIIGRLSIKNEYNDAVIPIKDLK 638
P + C C G L +D K C + E FL+++ N + L + E + +++
Sbjct: 2360 LPGLHTPKCDCAFGT-LQSDGKNCAISTENFLIFALSNSLRSLHLDPENHSPPFQTINVE 2418
Query: 639 EVSALALYVSGS-KLYWSDSKTKTINRCSVN--GSAVEK---IVEWLGLVEGLAIDWSGQ 692
Y S S ++Y++ + + + S S + I +G +G+A DW +
Sbjct: 2419 RTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITR 2478
Query: 693 NIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS-IKRAA 751
IY++D Q I DGS+R I + KP++IVLDP +GY+YW++ + + I+RA
Sbjct: 2479 RIYYSDYLNQMINSMAEDGSNRTVIA--RVPKPRAIVLDPCQGYLYWADWDTHAKIERAT 2536
Query: 752 MDGS-SVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPMPY 810
+ G+ V + + L +DYE +YW +E + L G R+ + + +
Sbjct: 2537 LGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAVHAF 2596
Query: 811 ALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLK----LYHRAKSMGSNQ 866
L L+ +YW D T +I +A K DGS + ++ +L +S + + K +N
Sbjct: 2597 GLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNL--LSQPRGINTVVKNQKQQCNNP 2654
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACP 894
C NGGCSH+C P P C CP
Sbjct: 2655 CEQFNGGCSHICAPGPNGA----ECQCP 2678
Score = 294 bits (722), Expect = 1e-78
Identities = 178/616 (28%), Positives = 310/616 (50%), Gaps = 32/616 (5%)
Query: 6 RLTRITTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVT 65
R RI +++ V FHY + W+D + ++ N E + E T
Sbjct: 412 RSFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVE---T 468
Query: 66 PTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTD 125
P +A+DW +K+Y + + N+I+++++ YR L + R IAV P G +F++D
Sbjct: 469 PENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSD 528
Query: 126 WGEI---PKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDF 182
W + PK+ERA M+G + RK +V+ + WP G+T+D + +YWVD++ +++ + +
Sbjct: 529 WESLSGEPKLERAFMDG--SNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTY 586
Query: 183 NGEKRKRVVKGG--LVYPFALTFSNDKLYWTDWQNWSIYTWD-IAANGPKIKELIKSHPV 239
+G +RK VV GG + +PF ++ ++++TDW ++ + P++ ++
Sbjct: 587 DGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQV--YYQASLR 644
Query: 240 PADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLS----PDPPGYNCACPTGVKLRENSS 295
P + VY RQ + PCK NN GC +C+LS D G+ C C G +L +
Sbjct: 645 PYGVTVYHSLRQPYATN--PCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQL-DTDE 701
Query: 296 TTCYDSPQMLLVVAQRSTISKISLDSPDFTPYTLPLK-DLKRTLTVDFDPKTEYIYWADG 354
C + Q L+ + + I I +P+ + + +DFD + I+++D
Sbjct: 702 RHCI-AVQNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDM 760
Query: 355 LAKTISKARLDGSDQSVVV--RSSGVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEK 412
I K ++DG+ + ++ R V +S+A D +S+ +YWTD +I+V RL +
Sbjct: 761 SKHMIFKQKIDGTGREILAANRVENV-ESLAFDWISKNLYWTDSHYKSISVMRLADKTRR 819
Query: 413 VIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIAL 472
++ L +PR++ +H AG++F++DW + KI RA DGS + +I+ L WPN +A+
Sbjct: 820 TVVQ-YLNNPRSVVVHPFAGYLFFTDW-FRPAKIMRAWSDGSHLLPVINTTLGWPNGLAI 877
Query: 473 DTVNNKLYWGDARTHKIEVCNMDGTERKEL-HSNDIIHIFGXXXXXXXXXXXXMQKRTLD 531
D ++LYW DA KIE DG +R+ L H + H FG + +
Sbjct: 878 DWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAII 937
Query: 532 RINKNTGLDRQPVVEQMANMMGVKAFRLGAPLGWNPC---ADDNGGCSHLCFNRPD-DYI 587
R+ K G + + +A ++ +K++ + G N C NG CSH CF P+ +
Sbjct: 938 RVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRV 997
Query: 588 CGCPLGLELTADKKTC 603
CGCP G+ L ++ TC
Sbjct: 998 CGCPYGMRLASNHLTC 1013
Score = 212 bits (517), Expect = 7e-54
Identities = 159/564 (28%), Positives = 267/564 (47%), Gaps = 37/564 (6%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTC----VEPEAFLVYSRKNIIGRLSIKNEYN 628
G CS C+N + C C G L +D +TC E LV S+ II S+ ++ +
Sbjct: 1398 GSCSQHCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKIIAD-SVTSQVH 1456
Query: 629 DAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVE-WLGLVEGLAI 687
+ +++ + A+ +++WSD+ NG+ + + + L E +AI
Sbjct: 1457 NIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAI 1516
Query: 688 DWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPK--KGYMYWSELG-S 744
DW G+N+YWTD + IEVS++DGS R +I + L P+ + LDP+ + ++WS+ G
Sbjct: 1517 DWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHH 1576
Query: 745 KSIKRAAMDGSSVSVFM-EQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNG-TGRQTL 802
I+RA+MDGS +V + +++ L IDY R +Y+ ++F NG RQ +
Sbjct: 1577 PRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVI 1636
Query: 803 ADN--IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHRAK 860
A + I PYAL LF DSVYW D T ++ +A K G N+ + ++ + + H +K
Sbjct: 1637 ASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSK 1696
Query: 861 SMGS-NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC-SEPEEFLLFAQK 918
S N C CSHLCL + Y C CP+ + L+ D + C + + FL+ ++
Sbjct: 1697 QPNSVNPCAFSR--CSHLCLLSSQGPHF-YSCVCPSGWSLSPDLLNCLRDDQPFLITVRQ 1753
Query: 919 NAV-GRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXX 977
+ + G + + NDA +P+ G++N +E+D E+ +YW+++ I RV
Sbjct: 1754 HIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPG-EIHRVKTD--GTN 1810
Query: 978 XXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNN---SSTGVIVRGDRM 1034
G S ++ LD + R +Y T SI ++ + T + G +
Sbjct: 1811 RTVFASISMVGPS--MNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTAL 1868
Query: 1035 ---LPRHLAFHQTKRYLIWNDVGRGA-----IMRANVDGTGRVEL--ARADNATALALDQ 1084
P + + L W+D G + I AN+DGT L ++ + LD
Sbjct: 1869 GVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDI 1928
Query: 1085 SAGTVYWAVSRQCDGQQDCEDGRD 1108
+YWAV+ + ++ DG D
Sbjct: 1929 EEQKLYWAVTGRGVIERGNVDGTD 1952
Score = 199 bits (485), Expect = 6e-50
Identities = 112/340 (32%), Positives = 176/340 (51%), Gaps = 20/340 (5%)
Query: 575 CSHLCFNRPDDYICGCPLGLELTADKKTCVEP---EAFLVYSRKNIIGRLSIKNEYNDAV 631
CS C N YIC C G D KTC + E +L++S + + L+I + +
Sbjct: 3163 CSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLI 3222
Query: 632 IPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEW-LGLVEGLAIDWS 690
+ + L V AL +LYW D++ + I R +N + E I+ L E LA+DW
Sbjct: 3223 L--EGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWV 3280
Query: 691 GQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLK--------KPKSIVLDPKKGYMYWSEL 742
+ +YW D + VS L+G RR + + P+ + L P+ GY+YW++
Sbjct: 3281 SRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADW 3340
Query: 743 GSKS-IKRAAMDGSSVSVFME-QVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQ 800
G ++ I R MDG++ SV + ++ + + IDY +YWA +E++ L G R
Sbjct: 3341 GHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRH 3400
Query: 801 TLADN-IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHRA 859
T+ D +P P+A+ +F D++YW DWNT +++ K DGSNR+++ D+ +YH
Sbjct: 3401 TVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPY 3460
Query: 860 KS-MGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYR 898
+ + SN CG +NGGCSHLCL PG + C CP +R
Sbjct: 3461 RQPIVSNPCGTNNGGCSHLCLIKPGG--KGFTCECPDDFR 3498
Score = 192 bits (468), Expect = 6e-48
Identities = 103/295 (34%), Positives = 154/295 (52%), Gaps = 17/295 (5%)
Query: 13 IAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAID 72
I + L+ A+DF + + W D + ++I+ M N+T K I++ L +A+D
Sbjct: 3222 ILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKT---NKETIINHRLPAAESLAVD 3278
Query: 73 WYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDL--------ARAIAVVPEDGLMFWT 124
W + KLYW D + + V + +R++L VD R +A+ P+ G ++W
Sbjct: 3279 WVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWA 3338
Query: 125 DWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNG 184
DWG I R GM+G + VI+ + WPNGIT+DY N L+YW DA L +++ D G
Sbjct: 3339 DWGHRAYIGRVGMDG--TNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEG 3396
Query: 185 EKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIK 244
R V G L +PFA+T D +YWTDW ++ + +G + L+ + P DI
Sbjct: 3397 HHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGN-KYDGSNRQTLVNTTHRPFDIH 3455
Query: 245 VYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVK-LRENSSTTC 298
VY RQ I + PC NN GCSHLCL+ P G+ C CP + L+ + ST C
Sbjct: 3456 VYHPYRQPIVSN--PCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYC 3508
Score = 175 bits (425), Expect = 1e-42
Identities = 91/237 (38%), Positives = 138/237 (58%), Gaps = 11/237 (4%)
Query: 63 LVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMF 122
++ P GIA+DW +YW+D + +IEV + +YRK L +++D AIAV P+ GLMF
Sbjct: 4141 VMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMF 4200
Query: 123 WTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDY-NNSLIYWVDAKLQFVDVID 181
WTDWG+ PK E A MNG+ R ++V +++ WP G+++DY NN IYW D K ++ I
Sbjct: 4201 WTDWGKEPKXESAWMNGE--DRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIK 4258
Query: 182 FNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPA 241
++G R RV+ + P++L D+LYW + ++ + G K K L+ +P
Sbjct: 4259 YDGTDR-RVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLV-VNPWLT 4316
Query: 242 DIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTC 298
++++ + R S + CK+ CSHLCLL P GY+CACP G E S+T C
Sbjct: 4317 QVRIFHQLRYNKSVPNL-CKQI---CSHLCLLRPG--GYSCACPQGSSFIEGSTTEC 4367
Score = 172 bits (418), Expect = 7e-42
Identities = 97/326 (29%), Positives = 164/326 (50%), Gaps = 19/326 (5%)
Query: 280 YNCACPTGVKLRENSSTTCYDSPQM--LLVVAQRSTISKISLDSPDFTPYTLPLKDLKRT 337
Y C C G LRE TC + + L+ + R + +++D Y+L L+ L
Sbjct: 3174 YICKCAPGY-LREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYF---YSLILEGLDNV 3229
Query: 338 LTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSS-GVPDSIAIDPLSRKIYWTDP 396
+ +DFD + +YW D + I + L+ +++ ++ +S+A+D +SRK+YW D
Sbjct: 3230 VALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDA 3289
Query: 397 VMDTINVARLDGSYEKVII-------HTELYD-PRAIALHLTAGWMFWSDWNEKKPKIER 448
+D + V+ L+G + +++ +T +D PR +ALH G+++W+DW + I R
Sbjct: 3290 RLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRA-YIGR 3348
Query: 449 ANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDII 508
+DG+ + ++IS KL WPN I +D N+ LYW DA IE +++G R ++ +
Sbjct: 3349 VGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALP 3408
Query: 509 HIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFR-LGAPLGWNP 567
H F RT+++ NK G +RQ +V + + P+ NP
Sbjct: 3409 HPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNP 3468
Query: 568 CADDNGGCSHLCFNRP--DDYICGCP 591
C +NGGCSHLC +P + C CP
Sbjct: 3469 CGTNNGGCSHLCLIKPGGKGFTCECP 3494
Score = 167 bits (406), Expect = 2e-40
Identities = 135/565 (23%), Positives = 247/565 (43%), Gaps = 36/565 (6%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTCVEP---EAFLVYS--RKNIIGRLSIKNEY 627
G C C +RP ++C C G L + EA +++S R +IG I
Sbjct: 356 GICDQKCESRPGRHLCHCEEGYILERGQYCKANDSFGEASIIFSNGRDLLIG--DIHGRS 413
Query: 628 NDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEW-LGLVEGLA 686
++ ++ +A + +++W+D+ + +NG +++++ + E LA
Sbjct: 414 FRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLA 473
Query: 687 IDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMY---WSEL- 742
+DW IY +T RI++ LDGS R +I + L P+ I +DP GY++ W L
Sbjct: 474 VDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLS 533
Query: 743 GSKSIKRAAMDGSSVSVFME-QVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQT 801
G ++RA MDGS+ ++ ++G + +D + +YW +E +G R+T
Sbjct: 534 GEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKT 593
Query: 802 LADN---IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHR 858
+ IP P+ ++LF V++ DW + +A K +N + + + +YH
Sbjct: 594 VVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHS 653
Query: 859 AKS-MGSNQCGVDNGGCSHLCLPTPGDVRTD-----YRCACPAHYRLNKDNITCSEPEEF 912
+ +N C +NGGC +C+ + RTD +RC C ++L+ D C + F
Sbjct: 654 LRQPYATNPCKDNNGGCEQVCVLSH---RTDNDGLGFRCKCTFGFQLDTDERHCIAVQNF 710
Query: 913 LLFAQKNAVGRIMVANGECNDAYIPLTGLKN-VRAIEYDPVEKQLYWMDDDSHSIRRVPI 971
L+F+ + A+ I D +P++G + I++D + +++ D H I + I
Sbjct: 711 LIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKI 770
Query: 972 SYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRG 1031
+ + D + + +YWT + SI+ + + + V+
Sbjct: 771 D-----GTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVVQYL 825
Query: 1032 DRMLPRHLAFHQTKRYLIWNDVGRGA-IMRANVDGTGRVELARADNA--TALALDQSAGT 1088
+ PR + H YL + D R A IMRA DG+ + + LA+D +A
Sbjct: 826 NN--PRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASR 883
Query: 1089 VYWAVSRQCDGQQDCEDGRDEAECG 1113
+YW + + DG D G
Sbjct: 884 LYWVDAYFDKIEHSTFDGLDRRRLG 908
Score = 132 bits (318), Expect = 1e-29
Identities = 71/217 (32%), Positives = 119/217 (54%), Gaps = 12/217 (5%)
Query: 683 EGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
+G+A+DW G++IYW+D +RIEV++LDG R+ +I L +P +I ++PK G M+W++
Sbjct: 4145 DGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDW 4204
Query: 743 GSK-SIKRAAMDGSSVSVFM-EQVGRVHALAIDY-ERRAIYWAALDPPVVEFAFLNGTGR 799
G + + A M+G ++ + E +G L+IDY IYW+ V+E +GT R
Sbjct: 4205 GKEPKXESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDR 4264
Query: 800 QTLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHRA 859
+ +A PY+L +F D +YW G++ + K ++ +++ ++++H+
Sbjct: 4265 RVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFHQL 4324
Query: 860 KSMGS--NQCGVDNGGCSHLCLPTPGDVRTDYRCACP 894
+ S N C CSHLCL PG Y CACP
Sbjct: 4325 RYNKSVPNLC---KQICSHLCLLRPG----GYSCACP 4354
Score = 130 bits (315), Expect = 2e-29
Identities = 98/335 (29%), Positives = 157/335 (46%), Gaps = 27/335 (8%)
Query: 280 YNCACPTG-VKLRENSSTTCY-DSPQMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRT 337
Y C C G + + C + LL++ I K +L S F+ Y L ++ +
Sbjct: 4028 YECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEY-LQDEEYIQA 4086
Query: 338 LTVDFDPKT---EYIYWA---DGLA-KTISKARLDGSD-------QSVVVRSSGV--PDS 381
+ D+DP +Y+ +G I +A + + Q V ++ V PD
Sbjct: 4087 VDYDWDPXDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDG 4146
Query: 382 IAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNE 441
IA+D + R IYW+D I VA+LDG Y K +I T+L P AIA++ G MFW+DW
Sbjct: 4147 IAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWG- 4205
Query: 442 KKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNN-KLYWGDARTHKIEVCNMDGTERK 500
K+PK E A ++G R +L+ E L WP +++D +NN ++YW D + IE DGT+R+
Sbjct: 4206 KEPKXESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRR 4265
Query: 501 ELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFRLG 560
+ + + ++ + +K + + NK ++ + + V+ F
Sbjct: 4266 VI-AKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFH-- 4322
Query: 561 APLGWNPCADD--NGGCSHLCFNRPDDYICGCPLG 593
L +N + CSHLC RP Y C CP G
Sbjct: 4323 -QLRYNKSVPNLCKQICSHLCLLRPGGYSCACPQG 4356
Score = 77.0 bits (181), Expect = 4e-13
Identities = 69/245 (28%), Positives = 109/245 (44%), Gaps = 13/245 (5%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQ--MLLVVAQRSTISKI 317
C N GC+H C+ +P G C CP G L N S TC D + +L +Q +
Sbjct: 1353 CSDFNGGCTHECV--QEPFGAKCLCPLGF-LLANDSKTCEDIDECDILGSCSQHCYNMRG 1409
Query: 318 SLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSG 377
S T Y L+ RT V + + S + S+V S
Sbjct: 1410 SFRCSCDTGYM--LESDGRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSLVENGSY 1467
Query: 378 VPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWS 437
+ ++ D +S +I+W+D A +G+ +V+ + + IA+ ++W+
Sbjct: 1468 IV-AVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWT 1526
Query: 438 DWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNK--LYWGDARTH-KIEVCNM 494
D+ IE + +DGS R +LIS+ LT P +ALD N+ L+W D H +IE +M
Sbjct: 1527 DY--ALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASM 1584
Query: 495 DGTER 499
DG+ R
Sbjct: 1585 DGSMR 1589
Score = 70.5 bits (165), Expect = 3e-11
Identities = 68/263 (25%), Positives = 116/263 (44%), Gaps = 22/263 (8%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE-PEAFLVYSRK----NIIG- 619
N C+D NGGC+H C P C CPLG L D KTC + E ++ S N+ G
Sbjct: 1351 NSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRGS 1410
Query: 620 -RLSIKNEY--NDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIV 676
R S Y K S L L S +K+ +DS T ++ + +V
Sbjct: 1411 FRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKII-ADSVTSQVHN-------IYSLV 1462
Query: 677 EWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGY 736
E + + D I+W+D T + + +G+ RR + + ++I +D
Sbjct: 1463 ENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRN 1522
Query: 737 MYWSELGSKSIKRAAMDGSSVSVFM-EQVGRVHALAID--YERRAIYWAAL-DPPVVEFA 792
+YW++ ++I+ + +DGS +V + + + LA+D ++W+ P +E A
Sbjct: 1523 LYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERA 1582
Query: 793 FLNGTGRQTLA-DNIPMPYALAL 814
++G+ R + D I P L +
Sbjct: 1583 SMDGSMRTVIVQDKIFWPCGLTI 1605
Score = 67.3 bits (157), Expect = 3e-10
Identities = 71/301 (23%), Positives = 127/301 (42%), Gaps = 29/301 (9%)
Query: 564 GWNPCADDN-GGCSHLCFNRPDDYICGCPLGLELTADKKTCVE----PEAFLVYSRK--N 616
G N C D + GC H C + + C C G +L +DK+TCV+ E V S+K N
Sbjct: 3110 GINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCEN 3169
Query: 617 IIGRLSIKNEYNDAVIPI-KDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKI 675
+IG K P K ++ S + Y+ S Y+ + +++G I
Sbjct: 3170 VIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYY-------LRNLTIDGYFYSLI 3222
Query: 676 VEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKG 735
+E L V L D + +YW DT Q IE L+ +++ II L +S+ +D
Sbjct: 3223 LEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSR 3282
Query: 736 YMYWSELGSKSIKRAAMDGSSVSVFMEQ---------VGRVHALAIDYERRAIYWAAL-D 785
+YW + + + ++G + + LA+ + +YWA
Sbjct: 3283 KLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGH 3342
Query: 786 PPVVEFAFLNGTGRQT-LADNIPMPYALAL--FNDSVYWGDWNTGQIQQARKTDGSNRKS 842
+ ++GT + ++ + P + + ND +YW D + G I+ + +G +R +
Sbjct: 3343 RAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYS-DLEGHHRHT 3401
Query: 843 I 843
+
Sbjct: 3402 V 3402
Score = 66.9 bits (156), Expect = 4e-10
Identities = 64/249 (25%), Positives = 103/249 (41%), Gaps = 24/249 (9%)
Query: 860 KSMGSNQCGVDNGGCSHL---CLPTPGDVRTDYRCACPAHYRLNKDNITC---SEPEEFL 913
K M + VD C+ + C +V Y C C Y D TC S E +L
Sbjct: 3142 KLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYL 3201
Query: 914 LFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISY 973
+F+ + + R + +G + L GL NV A+++D VEK+LYW+D I R+ ++
Sbjct: 3202 IFSNRYYL-RNLTIDGYFYS--LILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLN- 3257
Query: 974 XXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGV---IVR 1030
L + +D + R +YW A D + + ++ + V
Sbjct: 3258 ----KTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVD 3313
Query: 1031 GDRML----PRHLAFHQTKRYLIWNDVG-RGAIMRANVDGTGR--VELARADNATALALD 1083
+ PR LA H YL W D G R I R +DGT + + + + + +D
Sbjct: 3314 ANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITID 3373
Query: 1084 QSAGTVYWA 1092
+ +YWA
Sbjct: 3374 YTNDLLYWA 3382
Score = 66.5 bits (155), Expect = 5e-10
Identities = 65/249 (26%), Positives = 95/249 (38%), Gaps = 27/249 (10%)
Query: 945 RAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTM 1004
RAI DP + LYW D D+H+ I L P + LD +
Sbjct: 2510 RAIVLDPCQGYLYWADWDTHA----KIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLL 2565
Query: 1005 YWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTK-----RYLIWNDVGRGAIM 1059
YW A I +++ TGV DR + + A H +Y+ W D+ I
Sbjct: 2566 YWVDASLQRIERSTL-----TGV----DREVIVNAAVHAFGLTLYGQYIYWTDLYTQRIY 2616
Query: 1060 RAN-VDGTGRVELARADNATALALDQSAGTVYWAVSRQCDGQQDCEDGRDEAEC--GACG 1116
RAN DG+G++ + L+ + TV +QC+ + +G C G G
Sbjct: 2617 RANKYDGSGQIAMT----TNLLSQPRGINTVVKNQKQQCNNPCEQFNGGCSHICAPGPNG 2672
Query: 1117 GDVRCA-DGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDEA 1175
+ +C +G +F C G CI+ + CD C DGSDE
Sbjct: 2673 AECQCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGRCISEEWKCDNDNDCGDGSDEM 2732
Query: 1176 PAACAYGHT 1184
+ CA HT
Sbjct: 2733 ESVCAL-HT 2740
Score = 53.2 bits (122), Expect = 5e-06
Identities = 42/190 (22%), Positives = 82/190 (43%), Gaps = 13/190 (6%)
Query: 35 SDQKPELIQCMNY---NETYTGEKFKIVSEGLVTPTGIAIDWYTDKLYWTDGETNKIEVI 91
S+ +P LI Y N T G + ++ EGL + D +LYW D + IE +
Sbjct: 3195 SNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERM 3254
Query: 92 SIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERAGMNGD---PATRKVIV 148
+ + ++ + + A ++AV ++W D + + + +NG + +
Sbjct: 3255 FLNKTNKETIINHRLPAAESLAVDWVSRKLYWLD-ARLDGLFVSDLNGGHRRMLAQHCVD 3313
Query: 149 RDNIFW---PNGITVDYNNSLIYWVD-AKLQFVDVIDFNGEKRKRVVKGGLVYPFALT-- 202
+N F P G+ + +YW D ++ + +G + ++ L +P +T
Sbjct: 3314 ANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITID 3373
Query: 203 FSNDKLYWTD 212
++ND LYW D
Sbjct: 3374 YTNDLLYWAD 3383
Score = 53.2 bits (122), Expect = 5e-06
Identities = 43/152 (28%), Positives = 76/152 (50%), Gaps = 14/152 (9%)
Query: 724 KPKSIVLDPKKGYMYWSELGSKSIKRAAMDGSSVS-VFMEQVGRVHALAIDYERRAIYWA 782
+P I +D ++YWS++ +K I+ A +DG + + + A+A++ + ++W
Sbjct: 4143 QPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWT 4202
Query: 783 AL-DPPVVEFAFLNGTGRQTLA-DNIPMPYALA---LFNDSVYWGDWNTGQIQQARKTDG 837
P E A++NG R L +++ P L+ L ND +YW D+ I+ K DG
Sbjct: 4203 DWGKEPKXESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETI-KYDG 4261
Query: 838 SNRKSIRKD------LDYISDLKLYHRAKSMG 863
++R+ I K+ LD D +LY +K G
Sbjct: 4262 TDRRVIAKEAMNPYSLDIFED-QLYWISKEKG 4292
Score = 48.8 bits (111), Expect = 1e-04
Identities = 37/118 (31%), Positives = 44/118 (37%), Gaps = 23/118 (19%)
Query: 1097 CDGQQDCEDGRDEAEC--GACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDA------- 1147
CDG +DC DG DE C +CA G +A
Sbjct: 1168 CDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPP 1227
Query: 1148 -------FRCDE-GLCIAARFVCDGRPQCADGSDE----APAAC--AYGHTDQVNGIH 1191
F+C E G+CI + CDG P C GSDE P C +Y H D N IH
Sbjct: 1228 GMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIH 1285
Score = 43.2 bits (97), Expect = 0.006
Identities = 62/276 (22%), Positives = 101/276 (36%), Gaps = 35/276 (12%)
Query: 834 KTDGSNRKSIRKDLDYISDLKLYHRAKSMGSNQCGVDN-GGCSHLCLPTPGDVRTDYRCA 892
K D + K +++ D K G N+C + GC H C D T + C+
Sbjct: 3081 KCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISGCDHNCT----DTLTSFYCS 3136
Query: 893 CPAHYRLNKDNITCSEPEEF----LLFAQK--NAVGRIMVANGECNDAYIPLTGLKNVRA 946
C Y+L D TC + +E + +QK N +G + +C Y+ K R
Sbjct: 3137 CRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYIC---KCAPGYLREPDGKTCR- 3192
Query: 947 IEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYW 1006
+ +E Y + + + +R + I GL + D + + +YW
Sbjct: 3193 -QNSNIEP--YLIFSNRYYLRNLTID------GYFYSLILEGLDNVVALDFDRVEKRLYW 3243
Query: 1007 TCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGAIMRANVDGT 1066
R I + N ++ I+ LA R L W D + ++++G
Sbjct: 3244 IDTQRQVIERMFL-NKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGG 3302
Query: 1067 GRVELAR----------ADNATALALDQSAGTVYWA 1092
R LA+ DN LAL G +YWA
Sbjct: 3303 HRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWA 3338
Score = 42.3 bits (95), Expect = 0.010
Identities = 38/130 (29%), Positives = 46/130 (35%), Gaps = 20/130 (15%)
Query: 1063 VDGTGRVELARADNATALALDQSAGTVYWAVSRQCDGQQDCEDGRDEAEC-----GACGG 1117
VDG+ V N TA ++G V+ +CDG DC D DEA C G C
Sbjct: 1175 VDGSDEVGCVL--NCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHS 1232
Query: 1118 D-VRC------------ADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDG 1164
D +C DG F CD G CI ++CD
Sbjct: 1233 DEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRXWLCDR 1292
Query: 1165 RPQCADGSDE 1174
C D SDE
Sbjct: 1293 DNDCGDMSDE 1302
Score = 41.5 bits (93), Expect = 0.018
Identities = 31/89 (34%), Positives = 34/89 (38%), Gaps = 30/89 (33%)
Query: 1097 CDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCI 1156
CDG DC D DE CG C+ AF C G CI
Sbjct: 1045 CDGVDDCHDNSDEQLCGTLNNT--CSSS----------------------AFTCGHGECI 1080
Query: 1157 AARFVCDGRPQCADGSDE------APAAC 1179
A + CD R C DGSDE APA+C
Sbjct: 1081 PAHWRCDKRNDCVDGSDEHNCPTHAPASC 1109
Score = 41.5 bits (93), Expect = 0.018
Identities = 29/108 (26%), Positives = 39/108 (36%), Gaps = 9/108 (8%)
Query: 1068 RVELARADNATALALDQSAGTVYWAVSRQCDGQQ-DCEDGRDEAECGACGGDVRCADGTX 1126
RV L DN D S + + C + C GR + C + C D +
Sbjct: 2838 RVYLCDGDNDCG---DNSDENPTYCTTHTCSSSEFQCTSGRCIPQHWYCDQETDCFDASD 2894
Query: 1127 XXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
D F+CD G CI + ++CDG C D SDE
Sbjct: 2895 EPASCGHSERTCLA-----DEFKCDGGRCIPSEWICDGDNDCGDMSDE 2937
Score = 41.1 bits (92), Expect = 0.023
Identities = 31/90 (34%), Positives = 36/90 (40%), Gaps = 27/90 (30%)
Query: 1090 YWAVSRQCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFR 1149
YW +CDG DC DG DE E C DV C + FR
Sbjct: 3858 YW----KCDGDDDCGDGSDE-ELHLCL-DVPC---------------------NSPNRFR 3890
Query: 1150 CDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
CD CI + VC+G C DG+DE C
Sbjct: 3891 CDNNRCIYSHEVCNGVDDCGDGTDETEEHC 3920
Score = 40.7 bits (91), Expect = 0.031
Identities = 27/93 (29%), Positives = 33/93 (35%), Gaps = 13/93 (13%)
Query: 1096 QCDGQQDCEDGRDEAECGA--CG-GDVRCADGTXXXXX----------XXXXXXXXXXXX 1142
QCDGQ DC D DE C C + RC +
Sbjct: 3738 QCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRT 3797
Query: 1143 XXXDAFRCDEGLCIAARFVCDGRPQCADGSDEA 1175
+ F+C G C+ + CDG C D SDEA
Sbjct: 3798 CHPEYFQCTSGHCVHSELKCDGSADCLDASDEA 3830
Score = 40.7 bits (91), Expect = 0.031
Identities = 27/92 (29%), Positives = 50/92 (54%), Gaps = 7/92 (7%)
Query: 13 IAKDLEQGTAVDFHYRKNLICWSD--QKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIA 70
I+ DL+Q A+ + + L+ W+D ++P+ E ++ +V E L PTG++
Sbjct: 4180 ISTDLDQPAAIAVNPKLGLMFWTDWGKEPKXESAWMNGE----DRNILVFEDLGWPTGLS 4235
Query: 71 IDWY-TDKLYWTDGETNKIEVISIVQKYRKVL 101
ID+ D++YW+D + + IE I R+V+
Sbjct: 4236 IDYLNNDRIYWSDFKEDVIETIKYDGTDRRVI 4267
Score = 40.3 bits (90), Expect = 0.041
Identities = 39/153 (25%), Positives = 74/153 (48%), Gaps = 13/153 (8%)
Query: 20 GTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAIDWYTDKLY 79
G AVD+ R I WSD K + I+ + Y K+ ++S L P IA++ ++
Sbjct: 4146 GIAVDWVGRH--IYWSDVKNKRIEVAKLDGRY--RKW-LISTDLDQPAAIAVNPKLGLMF 4200
Query: 80 WTD-GETNKIEVISIVQKYRKVLFWSEVDLARAIAV-VPEDGLMFWTDWGEIPKIERAGM 137
WTD G+ K E + + R +L + ++ +++ + ++W+D+ E IE
Sbjct: 4201 WTDWGKEPKXESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKE-DVIETIKY 4259
Query: 138 NGDPATRKVIVRDNIFWPNGITVDYNNSLIYWV 170
+G R+VI ++ + N ++D +YW+
Sbjct: 4260 DG--TDRRVIAKEAM---NPYSLDIFEDQLYWI 4287
Score = 39.9 bits (89), Expect = 0.054
Identities = 27/84 (32%), Positives = 31/84 (36%), Gaps = 21/84 (25%)
Query: 1096 QCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLC 1155
+CDG DC D DEA+C R DG F C +C
Sbjct: 3816 KCDGSADCLDASDEADC-----PTRFPDGAYCQATM----------------FECKNHVC 3854
Query: 1156 IAARFVCDGRPQCADGSDEAPAAC 1179
I + CDG C DGSDE C
Sbjct: 3855 IPPYWKCDGDDDCGDGSDEELHLC 3878
Score = 39.5 bits (88), Expect = 0.071
Identities = 29/97 (29%), Positives = 36/97 (37%), Gaps = 14/97 (14%)
Query: 1096 QCDGQQDCEDGRDEAECG--ACGGDVRCADGTXXXXXXX---------XXXXXXXXXXXX 1144
+CD +DC DG DE +C C + C +G
Sbjct: 126 RCDHVRDCPDGADENDCQYPTCE-QLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEICL 184
Query: 1145 XDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAACAY 1181
+ F C G CI +VCD C DGSDE AC Y
Sbjct: 185 HNEFSCGNGECIPRAYVCDHDNDCQDGSDE--HACNY 219
Score = 39.5 bits (88), Expect = 0.071
Identities = 16/32 (50%), Positives = 17/32 (53%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F C G CI+ FVCD C DGSDE C
Sbjct: 3037 FTCQNGRCISKTFVCDEDNDCGDGSDELMHLC 3068
Score = 39.1 bits (87), Expect = 0.094
Identities = 23/73 (31%), Positives = 28/73 (38%), Gaps = 6/73 (8%)
Query: 1103 CEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVC 1162
C +GR +E C D C DG+ AF C G C+ + C
Sbjct: 2707 CSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPT------AFTCANGRCVQYSYRC 2760
Query: 1163 DGRPQCADGSDEA 1175
D C DGSDEA
Sbjct: 2761 DYYNDCGDGSDEA 2773
Score = 38.7 bits (86), Expect = 0.12
Identities = 17/47 (36%), Positives = 24/47 (51%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
N C NGGC+H C+ P +C CP + L D+ TC + +E
Sbjct: 1351 NSCSDFNGGCTHECVQEPFGA----KCLCPLGFLLANDSKTCEDIDE 1393
Score = 37.9 bits (84), Expect = 0.22
Identities = 23/77 (29%), Positives = 29/77 (37%), Gaps = 7/77 (9%)
Query: 1098 DGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIA 1157
D Q C++ + ++ C D C DG+ F C CI
Sbjct: 1111 DTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQ-------FNCPNHRCID 1163
Query: 1158 ARFVCDGRPQCADGSDE 1174
FVCDG C DGSDE
Sbjct: 1164 LSFVCDGDKDCVDGSDE 1180
Score = 37.9 bits (84), Expect = 0.22
Identities = 30/101 (29%), Positives = 38/101 (37%), Gaps = 16/101 (15%)
Query: 1096 QCDGQQDCEDGRDE-AECGA--CG-GDVRCADGTXXXXXXXXXXXXXXXXXXXXD----- 1146
+CDGQ+DC DG DE A C C G +C+DG D
Sbjct: 3531 KCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCE 3590
Query: 1147 -------AFRCDEGLCIAARFVCDGRPQCADGSDEAPAACA 1180
++C CI + CD C D SDE + CA
Sbjct: 3591 NHHCDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSSHCA 3631
Score = 37.9 bits (84), Expect = 0.22
Identities = 14/38 (36%), Positives = 20/38 (52%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAACAYGHTD 1185
F+C +G C + + +C+ C DGSDE C H D
Sbjct: 3558 FQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCD 3595
Score = 37.5 bits (83), Expect = 0.29
Identities = 26/93 (27%), Positives = 32/93 (34%), Gaps = 12/93 (12%)
Query: 1094 SRQCDGQQDCEDGRDEAECGA-C-GGDVRCADGTXXXXXXXXXXXXXXXXXXXXDA---- 1147
S++CD + DC D DE C C + C +G A
Sbjct: 161 SQKCDWKVDCRDSSDEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYP 220
Query: 1148 ------FRCDEGLCIAARFVCDGRPQCADGSDE 1174
F C G CI +VCDG C D DE
Sbjct: 221 TCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDE 253
Score = 37.5 bits (83), Expect = 0.29
Identities = 19/44 (43%), Positives = 21/44 (47%), Gaps = 3/44 (6%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDE---APAACAYGHTDQVN 1188
FRC CI R+ CDG+ C D SDE AP C VN
Sbjct: 3725 FRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVN 3768
Score = 37.1 bits (82), Expect = 0.38
Identities = 17/39 (43%), Positives = 21/39 (53%), Gaps = 3/39 (7%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDE---APAACAYGH 1183
FRC G CI A + CDG C+D +DE A C G+
Sbjct: 33 FRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGY 71
Score = 36.3 bits (80), Expect = 0.66
Identities = 23/90 (25%), Positives = 33/90 (36%), Gaps = 4/90 (4%)
Query: 1100 QQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAAR 1159
Q C++GR ++ C D C DG+ F+CD G CI
Sbjct: 3036 QFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHE----FKCDNGRCIEMM 3091
Query: 1160 FVCDGRPQCADGSDEAPAACAYGHTDQVNG 1189
+C+ C D SDE H ++G
Sbjct: 3092 KLCNHLDDCLDNSDEKGCGINECHDPSISG 3121
Score = 35.9 bits (79), Expect = 0.87
Identities = 25/76 (32%), Positives = 30/76 (39%), Gaps = 4/76 (5%)
Query: 1101 QDCEDGRDEAECGAC-GGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCD-EGLCIAA 1158
Q+C+ G C D RC DGT F+C EG CI +
Sbjct: 26 QECDSAHFRCGSGHCIPADWRC-DGTKDCSDDADEIGCAVVTCQQG-YFKCQSEGQCIPS 83
Query: 1159 RFVCDGRPQCADGSDE 1174
+VCD C DGSDE
Sbjct: 84 SWVCDQDQDCDDGSDE 99
Score = 35.9 bits (79), Expect = 0.87
Identities = 25/77 (32%), Positives = 27/77 (35%), Gaps = 9/77 (11%)
Query: 1105 DGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDG 1164
D R + C GDV C DG + F C GLCI F CD
Sbjct: 2962 DRRCIPQSWVCDGDVDCTDG-------YDENQNCTRRTCSENEFTCGYGLCIPKIFRCDR 3014
Query: 1165 RPQCADGSDEAPAACAY 1181
C D SDE C Y
Sbjct: 3015 HNDCGDYSDE--RGCLY 3029
Score = 35.5 bits (78), Expect = 1.2
Identities = 25/103 (24%), Positives = 53/103 (51%), Gaps = 4/103 (3%)
Query: 757 VSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTL-ADNIPMPYALALF 815
V + ++ V + +A+D+ R IYW+ + +E A L+G R+ L + ++ P A+A+
Sbjct: 4134 VDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVN 4193
Query: 816 N--DSVYWGDWNTGQIQQARKTDGSNRK-SIRKDLDYISDLKL 855
++W DW ++ +G +R + +DL + + L +
Sbjct: 4194 PKLGLMFWTDWGKEPKXESAWMNGEDRNILVFEDLGWPTGLSI 4236
Score = 33.9 bits (74), Expect = 3.5
Identities = 12/29 (41%), Positives = 16/29 (55%)
Query: 1151 DEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
+ +CI ++CDG C D SDE P C
Sbjct: 2831 NSNICIPRVYLCDGDNDCGDNSDENPTYC 2859
Score = 33.5 bits (73), Expect = 4.7
Identities = 12/28 (42%), Positives = 16/28 (57%)
Query: 1147 AFRCDEGLCIAARFVCDGRPQCADGSDE 1174
+F C G C+ ++CDG C D SDE
Sbjct: 1030 SFPCKNGRCVPNYYLCDGVDDCHDNSDE 1057
Score = 33.1 bits (72), Expect = 6.2
Identities = 17/54 (31%), Positives = 25/54 (46%)
Query: 1039 LAFHQTKRYLIWNDVGRGAIMRANVDGTGRVELARADNATALALDQSAGTVYWA 1092
+AF R + ++D I DG+ R +AR A+ LD G +YWA
Sbjct: 2471 IAFDWITRRIYYSDYLNQMINSMAEDGSNRTVIARVPKPRAIVLDPCQGYLYWA 2524
>AC007556-2|AAX88965.1| 3881|Homo sapiens unknown protein.
Length = 3881
Score = 439 bits (1081), Expect = e-122
Identities = 322/1138 (28%), Positives = 545/1138 (47%), Gaps = 72/1138 (6%)
Query: 4 TSRLTRITTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGL 63
TS++ I ++ ++ AVDF I WSD Q ++ G ++V +
Sbjct: 678 TSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDAT----QGKTWSAFQNGTDRRVVFDSS 733
Query: 64 VTPTG-IAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPE--DGL 120
+ T IAIDW LYWTD IEV I +R VL + R +A+ P + L
Sbjct: 734 IILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHL 793
Query: 121 MFWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVI 180
+FW+DWG P+IERA M+G + R VIV+D IFWP G+T+DY N L+Y++D+ L ++D
Sbjct: 794 LFWSDWGHHPRIERASMDG--SMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFC 851
Query: 181 DFNGEKRKRVVKGGLV--YPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHP 238
D+NG R++V+ L+ +P+ALT D +YWTD + + +G ++ +
Sbjct: 852 DYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRAN-KWHGGNQSVVMYNIQ 910
Query: 239 VPADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPG-YNCACPTGVKLRENSSTT 297
P I S+Q S PC + CSHLCLLS P Y+C CP+G L +
Sbjct: 911 WPLGIVAVHPSKQPNSVN--PCAFSR--CSHLCLLSSQGPHFYSCVCPSGWSLSPD-LLN 965
Query: 298 CYDSPQMLLVVAQRSTISKISLD-SPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLA 356
C Q L+ ++ I ISL+ +P+ ++ L V+FD +YIYW +
Sbjct: 966 CLRDDQPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPG 1025
Query: 357 KTISKARLDGSDQSVVVRSSGVPDS--IAIDPLSRKIYWTDPVMDTINVARLDGS--YEK 412
+ I + + DG++++V S V S +A+D +SR +Y T+P +I V L G Y K
Sbjct: 1026 E-IHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRK 1084
Query: 413 VIIHTE-----LYDPRAIALHLTAGWMFWSDWNEKK---PKIERANLDGSGRVLLISEKL 464
+I + + P I + G ++WSD KI AN+DG+ L + L
Sbjct: 1085 TLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNL 1144
Query: 465 TWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXXXXXXXXXX 524
+ LD KLYW IE N+DGT+R L + + H +G
Sbjct: 1145 EHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMIL-VHQLSHPWGIAVHDSFLYYTD 1203
Query: 525 MQKRTLDRINKNTGLDRQPVVEQMANMMGVKAF-RLGAPLGWNPCADDNGGCSHLCFNRP 583
Q ++R++K TG ++ + + + N+ G++ + R A N C+++ C +C P
Sbjct: 1204 EQYEVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNNMNACQQICLPVP 1263
Query: 584 DD-YICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGRLSIK-NEYNDAVIPIKDL-KEV 640
+ C C G +L D ++C +F+V S + I S++ +++++ ++P+ +
Sbjct: 1264 GGLFSCACATGFKLNPDNRSCSPYNSFIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNA 1323
Query: 641 SALALYVSGSKLYWSD-----SKTKTINRCSVNGSAVEKIV-EWLGL--VEGLAIDWSGQ 692
+ + VS +YW D + I R +GS++ IV +G V G+A+DW
Sbjct: 1324 LHVDVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAG 1383
Query: 693 NIYWTDTTTQR--IEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSK-SIKR 749
N+Y+T+ IEV R++ + RR ++ + P+ IV+DPK Y++W++ G + I+R
Sbjct: 1384 NLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQRPKIER 1443
Query: 750 AAMDGSSVSVFM-EQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTL--ADNI 806
+ +D ++ +V + E + LA+D +YW ++ +NG + +
Sbjct: 1444 SFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRY 1503
Query: 807 PMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKS--IRKDLDYISDLKLYHR------ 858
P PY + +F +S+ W D N +I QA K + IR +++++ D+ ++ +
Sbjct: 1504 PTPYGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRS 1563
Query: 859 AKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS-EPEEFLLFAQ 917
+ +N C +NGGCSHLC PG + T +C C A L D C+ E FL+FA
Sbjct: 1564 PAEVNNNPCLENNGGCSHLCFALPG-LHTP-KCDC-AFGTLQSDGKNCAISTENFLIFAL 1620
Query: 918 KNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXX 977
N++ + + + + + + V +++YD V ++Y+ + + + + ISY
Sbjct: 1621 SNSLRSLHLDPENHSPPFQTINVERTVMSLDYDSVSDRIYFTQNLASGVGQ--ISYATLS 1678
Query: 978 XXXXX-XXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLP 1036
G+ + D + R +Y++ IN+ + D ++ T VI R + P
Sbjct: 1679 SGIHTPTVIASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNRT-VIARVPK--P 1735
Query: 1037 RHLAFHQTKRYLIWNDVGRGA-IMRANVDGTGRVELARAD--NATALALDQSAGTVYW 1091
R + + YL W D A I RA + G RV + + + L LD +YW
Sbjct: 1736 RAIVLDPCQGYLYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYW 1793
Score = 362 bits (890), Expect = 5e-99
Identities = 252/853 (29%), Positives = 424/853 (49%), Gaps = 54/853 (6%)
Query: 280 YNCACPTGVKLRENSSTTC--YDSPQMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRT 337
+ C+C TG L E+ TC S +LL+VA ++ I S+ S Y+L +++
Sbjct: 637 FRCSCDTGYML-ESDGRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSL-VENGSYI 694
Query: 338 LTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGV-PDSIAIDPLSRKIYWTDP 396
+ VDFD + I+W+D A +G+D+ VV SS + ++IAID + R +YWTD
Sbjct: 695 VAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDY 754
Query: 397 VMDTINVARLDGSYEKVIIHTELYDPRAIAL--HLTAGWMFWSDWNEKKPKIERANLDGS 454
++TI V+++DGS+ V+I L +PR +AL + +FWSDW P+IERA++DGS
Sbjct: 755 ALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGH-HPRIERASMDGS 813
Query: 455 GRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDII--HIFG 512
R +++ +K+ WP + +D N LY+ D+ ++ C+ +G R+++ ++D+I H +
Sbjct: 814 MRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYA 873
Query: 513 XXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFRLG-APLGWNPCADD 571
R + R NK G ++ V+ + +G+ A P NPCA
Sbjct: 874 LTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFS 933
Query: 572 NGGCSHLCF---NRPDDYICGCPLGLELTADKKTCV-EPEAFLVYSRKNIIGRLSIKNEY 627
CSHLC P Y C CP G L+ D C+ + + FL+ R++II +S+ E
Sbjct: 934 R--CSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNCLRDDQPFLITVRQHIIFGISLNPEV 991
Query: 628 --NDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGS--AVEKIVEWLGLVE 683
NDA++PI ++ + + +YW ++ + I+R +G+ V + +G
Sbjct: 992 KSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPGE-IHRVKTDGTNRTVFASISMVGPSM 1050
Query: 684 GLAIDWSGQNIYWTDTTTQRIEVSRLDGS--SRRAIIWQ-----GLKKPKSIVLDPKKGY 736
LA+DW +N+Y T+ TQ IEV L G R+ +I G+ P I +DP +G
Sbjct: 1051 NLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGK 1110
Query: 737 MYWSELGSKS-----IKRAAMDGSSV-SVFMEQVGRVHALAIDYERRAIYWAALDPPVVE 790
+YWS+ G+ S I A MDG+SV ++F + + + +D E + +YWA V+E
Sbjct: 1111 LYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIE 1170
Query: 791 FAFLNGTGRQTLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYI 850
++GT R L + P+ +A+ + +Y+ D I++ K G+N+ +R ++ +
Sbjct: 1171 RGNVDGTDRMILVHQLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNL 1230
Query: 851 SDLKLYHRAKSM-GSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEP 909
L++YHR + SN C + C +CLP PG + + CAC ++LN DN +CS
Sbjct: 1231 RGLQVYHRRNAAESSNGCSNNMNACQQICLPVPGGL---FSCACATGFKLNPDNRSCSPY 1287
Query: 910 EEFLLFAQKNAVGRIMVANGECNDAYIPLTGL-KNVRAIEYDPVEKQLYWMDDDS----- 963
F++ + +A+ + + ++ +P+ G +N ++ D +YW D S
Sbjct: 1288 NSFIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASD 1347
Query: 964 HSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCA--DRDSINATSIDN 1021
++IRR+ G+ + +D + +Y+T A I I N
Sbjct: 1348 NAIRRIKPDGSSLMNIVTHGIGENGVR---GIAVDWVAGNLYFTNAFVSETLIEVLRI-N 1403
Query: 1022 NSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVG-RGAIMRANVDGTGRVELARADNAT-- 1078
+ V+++ +PRH+ RYL W D G R I R+ +D T R L T
Sbjct: 1404 TTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPR 1463
Query: 1079 ALALDQSAGTVYW 1091
LA+D+S G VYW
Sbjct: 1464 GLAVDRSDGYVYW 1476
Score = 299 bits (735), Expect = 3e-80
Identities = 254/928 (27%), Positives = 430/928 (46%), Gaps = 76/928 (8%)
Query: 17 LEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPT-GIAIDWYT 75
++ G V+F + I W + E+ + +T + S +V P+ +A+DW +
Sbjct: 1003 IQNGLDVEFDDAEQYIYWVENPGEIHRV----KTDGTNRTVFASISMVGPSMNLALDWIS 1058
Query: 76 DKLYWTDGETNKIEVISIVQ--KYRKVLFWSE-----VDLARAIAVVPEDGLMFWTDWGE 128
LY T+ T IEV+++ +YRK L ++ V I V P G ++W+D G
Sbjct: 1059 RNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGT 1118
Query: 129 ---IP-KIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNG 184
+P KI A M+G K + N+ +T+D +YW ++ + +G
Sbjct: 1119 DSGVPAKIASANMDGTSV--KTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDG 1176
Query: 185 EKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIK 244
R +V L +P+ + + LY+TD Q I D A KI L + P ++
Sbjct: 1177 TDRMILVHQ-LSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIV-LRDNVPNLRGLQ 1234
Query: 245 VYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPG-YNCACPTGVKLR-ENSSTTCYDSP 302
VY S+ C N C +CL P P G ++CAC TG KL +N S + Y+S
Sbjct: 1235 VYHRRNAAESSNG--CSNNMNACQQICL--PVPGGLFSCACATGFKLNPDNRSCSPYNS- 1289
Query: 303 QMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRT-LTVDFDPKTEYIYWADGLAKTIS- 360
+VV+ S I SL+ D + +P+ R L VD D + +IYW D + S
Sbjct: 1290 --FIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASD 1347
Query: 361 ----KARLDGSDQSVVVRSSGVPDS----IAIDPLSRKIYWTDP-VMDT-INVARLDGSY 410
+ + DGS +V + G+ ++ IA+D ++ +Y+T+ V +T I V R++ +Y
Sbjct: 1348 NAIRRIKPDGSSLMNIV-THGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTY 1406
Query: 411 EKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSI 470
+V++ + PR I + ++FW+D+ ++ PKIER+ LD + R +L+SE + P +
Sbjct: 1407 RRVLLKVTVDMPRHIVVDPKNRYLFWADYGQR-PKIERSFLDCTNRTVLVSEGIVTPRGL 1465
Query: 471 ALDTVNNKLYWGDARTHKIEVCNMDGTERKEL-HSNDIIHIFGXXXXXXXXXXXXMQKRT 529
A+D + +YW D I ++G + + + + +G +
Sbjct: 1466 AVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKK 1525
Query: 530 LDRINKNTGLDRQPVV--EQMANMMGVKAF------RLGAPLGWNPCADDNGGCSHLCFN 581
+ + +K P V + + + V F R A + NPC ++NGGCSHLCF
Sbjct: 1526 IFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFA 1585
Query: 582 RPDDYI--CGCPLGLELTADKKTC-VEPEAFLVYSRKNIIGRLSIKNEYNDAVIPIKDLK 638
P + C C G L +D K C + E FL+++ N + L + E + +++
Sbjct: 1586 LPGLHTPKCDCAFGT-LQSDGKNCAISTENFLIFALSNSLRSLHLDPENHSPPFQTINVE 1644
Query: 639 EVSALALYVSGS-KLYWSDSKTKTINRCSVN--GSAVEK---IVEWLGLVEGLAIDWSGQ 692
Y S S ++Y++ + + + S S + I +G +G+A DW +
Sbjct: 1645 RTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITR 1704
Query: 693 NIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS-IKRAA 751
IY++D Q I DGS+R I + KP++IVLDP +GY+YW++ + + I+RA
Sbjct: 1705 RIYYSDYLNQMINSMAEDGSNRTVIA--RVPKPRAIVLDPCQGYLYWADWDTHAKIERAT 1762
Query: 752 MDGS-SVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPMPY 810
+ G+ V + + L +DYE +YW +E + L G R+ + + +
Sbjct: 1763 LGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAVHAF 1822
Query: 811 ALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLK----LYHRAKSMGSNQ 866
L L+ +YW D T +I +A K DGS + ++ +L +S + + K +N
Sbjct: 1823 GLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNL--LSQPRGINTVVKNQKQQCNNP 1880
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACP 894
C NGGCSH+C P P C CP
Sbjct: 1881 CEQFNGGCSHICAPGPNGA----ECQCP 1904
Score = 212 bits (517), Expect = 7e-54
Identities = 159/564 (28%), Positives = 267/564 (47%), Gaps = 37/564 (6%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTC----VEPEAFLVYSRKNIIGRLSIKNEYN 628
G CS C+N + C C G L +D +TC E LV S+ II S+ ++ +
Sbjct: 624 GSCSQHCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKIIAD-SVTSQVH 682
Query: 629 DAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVE-WLGLVEGLAI 687
+ +++ + A+ +++WSD+ NG+ + + + L E +AI
Sbjct: 683 NIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAI 742
Query: 688 DWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPK--KGYMYWSELG-S 744
DW G+N+YWTD + IEVS++DGS R +I + L P+ + LDP+ + ++WS+ G
Sbjct: 743 DWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHH 802
Query: 745 KSIKRAAMDGSSVSVFM-EQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNG-TGRQTL 802
I+RA+MDGS +V + +++ L IDY R +Y+ ++F NG RQ +
Sbjct: 803 PRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVI 862
Query: 803 ADN--IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHRAK 860
A + I PYAL LF DSVYW D T ++ +A K G N+ + ++ + + H +K
Sbjct: 863 ASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSK 922
Query: 861 SMGS-NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC-SEPEEFLLFAQK 918
S N C CSHLCL + Y C CP+ + L+ D + C + + FL+ ++
Sbjct: 923 QPNSVNPCAFSR--CSHLCLLSSQGPHF-YSCVCPSGWSLSPDLLNCLRDDQPFLITVRQ 979
Query: 919 NAV-GRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXX 977
+ + G + + NDA +P+ G++N +E+D E+ +YW+++ I RV
Sbjct: 980 HIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPG-EIHRVKTD--GTN 1036
Query: 978 XXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNN---SSTGVIVRGDRM 1034
G S ++ LD + R +Y T SI ++ + T + G +
Sbjct: 1037 RTVFASISMVGPS--MNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTAL 1094
Query: 1035 ---LPRHLAFHQTKRYLIWNDVGRGA-----IMRANVDGTGRVEL--ARADNATALALDQ 1084
P + + L W+D G + I AN+DGT L ++ + LD
Sbjct: 1095 GVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDI 1154
Query: 1085 SAGTVYWAVSRQCDGQQDCEDGRD 1108
+YWAV+ + ++ DG D
Sbjct: 1155 EEQKLYWAVTGRGVIERGNVDGTD 1178
Score = 199 bits (485), Expect = 6e-50
Identities = 112/340 (32%), Positives = 176/340 (51%), Gaps = 20/340 (5%)
Query: 575 CSHLCFNRPDDYICGCPLGLELTADKKTCVEP---EAFLVYSRKNIIGRLSIKNEYNDAV 631
CS C N YIC C G D KTC + E +L++S + + L+I + +
Sbjct: 2389 CSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLI 2448
Query: 632 IPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEW-LGLVEGLAIDWS 690
+ + L V AL +LYW D++ + I R +N + E I+ L E LA+DW
Sbjct: 2449 L--EGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWV 2506
Query: 691 GQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLK--------KPKSIVLDPKKGYMYWSEL 742
+ +YW D + VS L+G RR + + P+ + L P+ GY+YW++
Sbjct: 2507 SRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADW 2566
Query: 743 GSKS-IKRAAMDGSSVSVFME-QVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQ 800
G ++ I R MDG++ SV + ++ + + IDY +YWA +E++ L G R
Sbjct: 2567 GHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRH 2626
Query: 801 TLADN-IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHRA 859
T+ D +P P+A+ +F D++YW DWNT +++ K DGSNR+++ D+ +YH
Sbjct: 2627 TVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPY 2686
Query: 860 KS-MGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYR 898
+ + SN CG +NGGCSHLCL PG + C CP +R
Sbjct: 2687 RQPIVSNPCGTNNGGCSHLCLIKPGG--KGFTCECPDDFR 2724
Score = 192 bits (468), Expect = 6e-48
Identities = 103/295 (34%), Positives = 154/295 (52%), Gaps = 17/295 (5%)
Query: 13 IAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAID 72
I + L+ A+DF + + W D + ++I+ M N+T K I++ L +A+D
Sbjct: 2448 ILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKT---NKETIINHRLPAAESLAVD 2504
Query: 73 WYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDL--------ARAIAVVPEDGLMFWT 124
W + KLYW D + + V + +R++L VD R +A+ P+ G ++W
Sbjct: 2505 WVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWA 2564
Query: 125 DWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNG 184
DWG I R GM+G + VI+ + WPNGIT+DY N L+YW DA L +++ D G
Sbjct: 2565 DWGHRAYIGRVGMDG--TNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEG 2622
Query: 185 EKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIK 244
R V G L +PFA+T D +YWTDW ++ + +G + L+ + P DI
Sbjct: 2623 HHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGN-KYDGSNRQTLVNTTHRPFDIH 2681
Query: 245 VYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVK-LRENSSTTC 298
VY RQ I + PC NN GCSHLCL+ P G+ C CP + L+ + ST C
Sbjct: 2682 VYHPYRQPIVSN--PCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYC 2734
Score = 177 bits (430), Expect = 3e-43
Identities = 92/237 (38%), Positives = 139/237 (58%), Gaps = 11/237 (4%)
Query: 63 LVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMF 122
++ P GIA+DW +YW+D + +IEV + +YRK L +++D AIAV P+ GLMF
Sbjct: 3367 VMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMF 3426
Query: 123 WTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDY-NNSLIYWVDAKLQFVDVID 181
WTDWG+ PKIE A MNG+ R ++V +++ WP G+++DY NN IYW D K ++ I
Sbjct: 3427 WTDWGKEPKIESAWMNGE--DRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIK 3484
Query: 182 FNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPA 241
++G R RV+ + P++L D+LYW + ++ + G K K L+ +P
Sbjct: 3485 YDGTDR-RVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLV-VNPWLT 3542
Query: 242 DIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTC 298
++++ + R S + CK+ CSHLCLL P GY+CACP G E S+T C
Sbjct: 3543 QVRIFHQLRYNKSVPNL-CKQI---CSHLCLLRPG--GYSCACPQGSSFIEGSTTEC 3593
Score = 172 bits (418), Expect = 7e-42
Identities = 97/326 (29%), Positives = 164/326 (50%), Gaps = 19/326 (5%)
Query: 280 YNCACPTGVKLRENSSTTCYDSPQM--LLVVAQRSTISKISLDSPDFTPYTLPLKDLKRT 337
Y C C G LRE TC + + L+ + R + +++D Y+L L+ L
Sbjct: 2400 YICKCAPGY-LREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYF---YSLILEGLDNV 2455
Query: 338 LTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSS-GVPDSIAIDPLSRKIYWTDP 396
+ +DFD + +YW D + I + L+ +++ ++ +S+A+D +SRK+YW D
Sbjct: 2456 VALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDA 2515
Query: 397 VMDTINVARLDGSYEKVII-------HTELYD-PRAIALHLTAGWMFWSDWNEKKPKIER 448
+D + V+ L+G + +++ +T +D PR +ALH G+++W+DW + I R
Sbjct: 2516 RLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRA-YIGR 2574
Query: 449 ANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDII 508
+DG+ + ++IS KL WPN I +D N+ LYW DA IE +++G R ++ +
Sbjct: 2575 VGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALP 2634
Query: 509 HIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFR-LGAPLGWNP 567
H F RT+++ NK G +RQ +V + + P+ NP
Sbjct: 2635 HPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNP 2694
Query: 568 CADDNGGCSHLCFNRP--DDYICGCP 591
C +NGGCSHLC +P + C CP
Sbjct: 2695 CGTNNGGCSHLCLIKPGGKGFTCECP 2720
Score = 144 bits (349), Expect = 2e-33
Identities = 82/232 (35%), Positives = 119/232 (51%), Gaps = 11/232 (4%)
Query: 682 VEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSE 741
VE LA DW +N+YWTD+ + I V RL +RR ++ Q L P+S+V+ P GY+++++
Sbjct: 12 VESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV-QYLNNPRSVVVHPFAGYLFFTD 70
Query: 742 -LGSKSIKRAAMDGSSV-SVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGR 799
I RA DGS + V +G + LAID+ +YW +E + +G R
Sbjct: 71 WFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDR 130
Query: 800 QTLA--DNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYH 857
+ L + + P+ LA+F + +++ DW G I + RK DG IR + YI LK Y
Sbjct: 131 RRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYD 190
Query: 858 RAKSMGSNQCGV---DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
GSN C NG CSH C P P R C CP RL +++TC
Sbjct: 191 VNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRV---CGCPYGMRLASNHLTC 239
Score = 138 bits (334), Expect = 1e-31
Identities = 75/229 (32%), Positives = 121/229 (52%), Gaps = 7/229 (3%)
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDW 439
+S+A D +S+ +YWTD +I+V RL + ++ L +PR++ +H AG++F++DW
Sbjct: 13 ESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVVQY-LNNPRSVVVHPFAGYLFFTDW 71
Query: 440 NEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTER 499
+ KI RA DGS + +I+ L WPN +A+D ++LYW DA KIE DG +R
Sbjct: 72 F-RPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDR 130
Query: 500 KEL-HSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFR 558
+ L H + H FG + + R+ K G + + +A ++ +K++
Sbjct: 131 RRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYD 190
Query: 559 LGAPLGWNPC---ADDNGGCSHLCFNRPD-DYICGCPLGLELTADKKTC 603
+ G N C NG CSH CF P+ +CGCP G+ L ++ TC
Sbjct: 191 VNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTC 239
Score = 136 bits (329), Expect = 4e-31
Identities = 103/354 (29%), Positives = 173/354 (48%), Gaps = 33/354 (9%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADK--KTCV-EPEAFLVYSRKNI-IGRL 621
N C + G C C N Y C C G +D+ K C E + L+ N+ I +
Sbjct: 3235 NEC-EQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKY 3293
Query: 622 SIKNE----------YNDAVIPIKDLKEVSALALY--VSGSKLYWSDSKTKTI-NRCSVN 668
++ +E Y AV D K++ +Y V G + K I N S
Sbjct: 3294 NLSSERFSEYLQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGR 3353
Query: 669 GSAVEKI---VEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKP 725
+ V+++ ++++ +G+A+DW G++IYW+D +RIEV++LDG R+ +I L +P
Sbjct: 3354 NNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQP 3413
Query: 726 KSIVLDPKKGYMYWSELGSK-SIKRAAMDGSSVSVFM-EQVGRVHALAIDY-ERRAIYWA 782
+I ++PK G M+W++ G + I+ A M+G ++ + E +G L+IDY IYW+
Sbjct: 3414 AAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWS 3473
Query: 783 ALDPPVVEFAFLNGTGRQTLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKS 842
V+E +GT R+ +A PY+L +F D +YW G++ + K ++
Sbjct: 3474 DFKEDVIETIKYDGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEK 3533
Query: 843 IRKDLDYISDLKLYHRAKSMGS--NQCGVDNGGCSHLCLPTPGDVRTDYRCACP 894
+++ ++++H+ + S N C CSHLCL PG Y CACP
Sbjct: 3534 TLVVNPWLTQVRIFHQLRYNKSVPNLC---KQICSHLCLLRPG----GYSCACP 3580
Score = 135 bits (326), Expect = 1e-30
Identities = 100/335 (29%), Positives = 159/335 (47%), Gaps = 27/335 (8%)
Query: 280 YNCACPTG-VKLRENSSTTCY-DSPQMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRT 337
Y C C G + + C + LL++ I K +L S F+ Y L ++ +
Sbjct: 3254 YECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEY-LQDEEYIQA 3312
Query: 338 LTVDFDPKT---EYIYWA---DGLA-KTISKARLDGSD-------QSVVVRSSGV--PDS 381
+ D+DPK +Y+ +G I +A + + Q V ++ V PD
Sbjct: 3313 VDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDG 3372
Query: 382 IAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNE 441
IA+D + R IYW+D I VA+LDG Y K +I T+L P AIA++ G MFW+DW
Sbjct: 3373 IAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWG- 3431
Query: 442 KKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNN-KLYWGDARTHKIEVCNMDGTERK 500
K+PKIE A ++G R +L+ E L WP +++D +NN ++YW D + IE DGT+R+
Sbjct: 3432 KEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRR 3491
Query: 501 ELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFRLG 560
+ + + ++ + +K + + NK ++ + + V+ F
Sbjct: 3492 VI-AKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFH-- 3548
Query: 561 APLGWNPCADD--NGGCSHLCFNRPDDYICGCPLG 593
L +N + CSHLC RP Y C CP G
Sbjct: 3549 -QLRYNKSVPNLCKQICSHLCLLRPGGYSCACPQG 3582
Score = 113 bits (272), Expect = 4e-24
Identities = 70/235 (29%), Positives = 111/235 (47%), Gaps = 7/235 (2%)
Query: 69 IAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGE 128
+A DW + LYWTD I V+ + K R+ + ++ R++ V P G +F+TDW
Sbjct: 15 LAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV-QYLNNPRSVVVHPFAGYLFFTDWFR 73
Query: 129 IPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRK 188
KI RA +G ++ + WPNG+ +D+ S +YWVDA ++ F+G R+
Sbjct: 74 PAKIMRAWSDGSHLLP--VINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRR 131
Query: 189 RVVK-GGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYD 247
R+ + +PF L + L++TDW+ +I A+G ++ + +K YD
Sbjct: 132 RLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVR-KADGGEMTVIRSGIAYILHLKSYD 190
Query: 248 ESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSP 302
+ Q S N CSH C P+ C CP G++L N TC P
Sbjct: 191 VNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRV-CGCPYGMRLASN-HLTCEGDP 243
Score = 77.0 bits (181), Expect = 4e-13
Identities = 69/245 (28%), Positives = 109/245 (44%), Gaps = 13/245 (5%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQ--MLLVVAQRSTISKI 317
C N GC+H C+ +P G C CP G L N S TC D + +L +Q +
Sbjct: 579 CSDFNGGCTHECV--QEPFGAKCLCPLGF-LLANDSKTCEDIDECDILGSCSQHCYNMRG 635
Query: 318 SLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSG 377
S T Y L+ RT V + + S + S+V S
Sbjct: 636 SFRCSCDTGYM--LESDGRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSLVENGSY 693
Query: 378 VPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWS 437
+ ++ D +S +I+W+D A +G+ +V+ + + IA+ ++W+
Sbjct: 694 IV-AVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWT 752
Query: 438 DWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNK--LYWGDARTH-KIEVCNM 494
D+ IE + +DGS R +LIS+ LT P +ALD N+ L+W D H +IE +M
Sbjct: 753 DY--ALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASM 810
Query: 495 DGTER 499
DG+ R
Sbjct: 811 DGSMR 815
Score = 70.5 bits (165), Expect = 3e-11
Identities = 68/263 (25%), Positives = 116/263 (44%), Gaps = 22/263 (8%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE-PEAFLVYSRK----NIIG- 619
N C+D NGGC+H C P C CPLG L D KTC + E ++ S N+ G
Sbjct: 577 NSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRGS 636
Query: 620 -RLSIKNEY--NDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIV 676
R S Y K S L L S +K+ +DS T ++ + +V
Sbjct: 637 FRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKII-ADSVTSQVHN-------IYSLV 688
Query: 677 EWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGY 736
E + + D I+W+D T + + +G+ RR + + ++I +D
Sbjct: 689 ENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRN 748
Query: 737 MYWSELGSKSIKRAAMDGSSVSVFM-EQVGRVHALAID--YERRAIYWAAL-DPPVVEFA 792
+YW++ ++I+ + +DGS +V + + + LA+D ++W+ P +E A
Sbjct: 749 LYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERA 808
Query: 793 FLNGTGRQTLA-DNIPMPYALAL 814
++G+ R + D I P L +
Sbjct: 809 SMDGSMRTVIVQDKIFWPCGLTI 831
Score = 67.3 bits (157), Expect = 3e-10
Identities = 71/301 (23%), Positives = 127/301 (42%), Gaps = 29/301 (9%)
Query: 564 GWNPCADDN-GGCSHLCFNRPDDYICGCPLGLELTADKKTCVE----PEAFLVYSRK--N 616
G N C D + GC H C + + C C G +L +DK+TCV+ E V S+K N
Sbjct: 2336 GINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCEN 2395
Query: 617 IIGRLSIKNEYNDAVIPI-KDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKI 675
+IG K P K ++ S + Y+ S Y+ + +++G I
Sbjct: 2396 VIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYY-------LRNLTIDGYFYSLI 2448
Query: 676 VEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKG 735
+E L V L D + +YW DT Q IE L+ +++ II L +S+ +D
Sbjct: 2449 LEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSR 2508
Query: 736 YMYWSELGSKSIKRAAMDGSSVSVFMEQ---------VGRVHALAIDYERRAIYWAAL-D 785
+YW + + + ++G + + LA+ + +YWA
Sbjct: 2509 KLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGH 2568
Query: 786 PPVVEFAFLNGTGRQT-LADNIPMPYALAL--FNDSVYWGDWNTGQIQQARKTDGSNRKS 842
+ ++GT + ++ + P + + ND +YW D + G I+ + +G +R +
Sbjct: 2569 RAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYS-DLEGHHRHT 2627
Query: 843 I 843
+
Sbjct: 2628 V 2628
Score = 66.9 bits (156), Expect = 4e-10
Identities = 64/249 (25%), Positives = 103/249 (41%), Gaps = 24/249 (9%)
Query: 860 KSMGSNQCGVDNGGCSHL---CLPTPGDVRTDYRCACPAHYRLNKDNITC---SEPEEFL 913
K M + VD C+ + C +V Y C C Y D TC S E +L
Sbjct: 2368 KLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYL 2427
Query: 914 LFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISY 973
+F+ + + R + +G + L GL NV A+++D VEK+LYW+D I R+ ++
Sbjct: 2428 IFSNRYYL-RNLTIDGYFYS--LILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLN- 2483
Query: 974 XXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGV---IVR 1030
L + +D + R +YW A D + + ++ + V
Sbjct: 2484 ----KTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVD 2539
Query: 1031 GDRML----PRHLAFHQTKRYLIWNDVG-RGAIMRANVDGTGR--VELARADNATALALD 1083
+ PR LA H YL W D G R I R +DGT + + + + + +D
Sbjct: 2540 ANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITID 2599
Query: 1084 QSAGTVYWA 1092
+ +YWA
Sbjct: 2600 YTNDLLYWA 2608
Score = 66.5 bits (155), Expect = 5e-10
Identities = 65/249 (26%), Positives = 95/249 (38%), Gaps = 27/249 (10%)
Query: 945 RAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTM 1004
RAI DP + LYW D D+H+ I L P + LD +
Sbjct: 1736 RAIVLDPCQGYLYWADWDTHA----KIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLL 1791
Query: 1005 YWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTK-----RYLIWNDVGRGAIM 1059
YW A I +++ TGV DR + + A H +Y+ W D+ I
Sbjct: 1792 YWVDASLQRIERSTL-----TGV----DREVIVNAAVHAFGLTLYGQYIYWTDLYTQRIY 1842
Query: 1060 RAN-VDGTGRVELARADNATALALDQSAGTVYWAVSRQCDGQQDCEDGRDEAEC--GACG 1116
RAN DG+G++ + L+ + TV +QC+ + +G C G G
Sbjct: 1843 RANKYDGSGQIAMT----TNLLSQPRGINTVVKNQKQQCNNPCEQFNGGCSHICAPGPNG 1898
Query: 1117 GDVRCA-DGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDEA 1175
+ +C +G +F C G CI+ + CD C DGSDE
Sbjct: 1899 AECQCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGRCISEEWKCDNDNDCGDGSDEM 1958
Query: 1176 PAACAYGHT 1184
+ CA HT
Sbjct: 1959 ESVCAL-HT 1966
Score = 53.2 bits (122), Expect = 5e-06
Identities = 42/190 (22%), Positives = 82/190 (43%), Gaps = 13/190 (6%)
Query: 35 SDQKPELIQCMNY---NETYTGEKFKIVSEGLVTPTGIAIDWYTDKLYWTDGETNKIEVI 91
S+ +P LI Y N T G + ++ EGL + D +LYW D + IE +
Sbjct: 2421 SNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERM 2480
Query: 92 SIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERAGMNGD---PATRKVIV 148
+ + ++ + + A ++AV ++W D + + + +NG + +
Sbjct: 2481 FLNKTNKETIINHRLPAAESLAVDWVSRKLYWLD-ARLDGLFVSDLNGGHRRMLAQHCVD 2539
Query: 149 RDNIFW---PNGITVDYNNSLIYWVD-AKLQFVDVIDFNGEKRKRVVKGGLVYPFALT-- 202
+N F P G+ + +YW D ++ + +G + ++ L +P +T
Sbjct: 2540 ANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITID 2599
Query: 203 FSNDKLYWTD 212
++ND LYW D
Sbjct: 2600 YTNDLLYWAD 2609
Score = 48.8 bits (111), Expect = 1e-04
Identities = 37/118 (31%), Positives = 44/118 (37%), Gaps = 23/118 (19%)
Query: 1097 CDGQQDCEDGRDEAEC--GACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDA------- 1147
CDG +DC DG DE C +CA G +A
Sbjct: 394 CDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPP 453
Query: 1148 -------FRCDE-GLCIAARFVCDGRPQCADGSDE----APAAC--AYGHTDQVNGIH 1191
F+C E G+CI + CDG P C GSDE P C +Y H D N IH
Sbjct: 454 GMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIH 511
Score = 44.0 bits (99), Expect = 0.003
Identities = 25/86 (29%), Positives = 43/86 (50%), Gaps = 2/86 (2%)
Query: 634 IKDLKEVSALALYVSGSKLYWSD-SKTKTINRCSVNGSAVEKIVEW-LGLVEGLAIDWSG 691
++ L ++ ++ L+++D + I R +GS + ++ LG GLAIDW+
Sbjct: 48 VQYLNNPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAA 107
Query: 692 QNIYWTDTTTQRIEVSRLDGSSRRAI 717
+YW D +IE S DG RR +
Sbjct: 108 SRLYWVDAYFDKIEHSTFDGLDRRRL 133
Score = 43.2 bits (97), Expect = 0.006
Identities = 29/108 (26%), Positives = 49/108 (45%), Gaps = 3/108 (2%)
Query: 334 LKRTLTVDFDPKTEYIYWADGLAKT-ISKARLDGSDQSVVVRSS-GVPDSIAIDPLSRKI 391
L +V P Y+++ D I +A DGS V+ ++ G P+ +AID + ++
Sbjct: 51 LNNPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRL 110
Query: 392 YWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDW 439
YW D D I + DG + + H E L + +F++DW
Sbjct: 111 YWVDAYFDKIEHSTFDGLDRRRLGHIEQM-THPFGLAIFGEHLFFTDW 157
Score = 43.2 bits (97), Expect = 0.006
Identities = 62/276 (22%), Positives = 101/276 (36%), Gaps = 35/276 (12%)
Query: 834 KTDGSNRKSIRKDLDYISDLKLYHRAKSMGSNQCGVDN-GGCSHLCLPTPGDVRTDYRCA 892
K D + K +++ D K G N+C + GC H C D T + C+
Sbjct: 2307 KCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISGCDHNCT----DTLTSFYCS 2362
Query: 893 CPAHYRLNKDNITCSEPEEF----LLFAQK--NAVGRIMVANGECNDAYIPLTGLKNVRA 946
C Y+L D TC + +E + +QK N +G + +C Y+ K R
Sbjct: 2363 CRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYIC---KCAPGYLREPDGKTCR- 2418
Query: 947 IEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYW 1006
+ +E Y + + + +R + I GL + D + + +YW
Sbjct: 2419 -QNSNIEP--YLIFSNRYYLRNLTID------GYFYSLILEGLDNVVALDFDRVEKRLYW 2469
Query: 1007 TCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGAIMRANVDGT 1066
R I + N ++ I+ LA R L W D + ++++G
Sbjct: 2470 IDTQRQVIERMFL-NKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGG 2528
Query: 1067 GRVELAR----------ADNATALALDQSAGTVYWA 1092
R LA+ DN LAL G +YWA
Sbjct: 2529 HRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWA 2564
Score = 42.3 bits (95), Expect = 0.010
Identities = 38/130 (29%), Positives = 46/130 (35%), Gaps = 20/130 (15%)
Query: 1063 VDGTGRVELARADNATALALDQSAGTVYWAVSRQCDGQQDCEDGRDEAEC-----GACGG 1117
VDG+ V N TA ++G V+ +CDG DC D DEA C G C
Sbjct: 401 VDGSDEVGCVL--NCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHS 458
Query: 1118 D-VRC------------ADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDG 1164
D +C DG F CD G CI ++CD
Sbjct: 459 DEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLCDR 518
Query: 1165 RPQCADGSDE 1174
C D SDE
Sbjct: 519 DNDCGDMSDE 528
Score = 42.3 bits (95), Expect = 0.010
Identities = 40/153 (26%), Positives = 75/153 (49%), Gaps = 13/153 (8%)
Query: 20 GTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAIDWYTDKLY 79
G AVD+ R I WSD K + I+ + Y K+ ++S L P IA++ ++
Sbjct: 3372 GIAVDWVGRH--IYWSDVKNKRIEVAKLDGRY--RKW-LISTDLDQPAAIAVNPKLGLMF 3426
Query: 80 WTD-GETNKIEVISIVQKYRKVLFWSEVDLARAIAV-VPEDGLMFWTDWGEIPKIERAGM 137
WTD G+ KIE + + R +L + ++ +++ + ++W+D+ E IE
Sbjct: 3427 WTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKE-DVIETIKY 3485
Query: 138 NGDPATRKVIVRDNIFWPNGITVDYNNSLIYWV 170
+G R+VI ++ + N ++D +YW+
Sbjct: 3486 DG--TDRRVIAKEAM---NPYSLDIFEDQLYWI 3513
Score = 41.9 bits (94), Expect = 0.013
Identities = 27/92 (29%), Positives = 51/92 (55%), Gaps = 7/92 (7%)
Query: 13 IAKDLEQGTAVDFHYRKNLICWSD--QKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIA 70
I+ DL+Q A+ + + L+ W+D ++P++ E ++ +V E L PTG++
Sbjct: 3406 ISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGE----DRNILVFEDLGWPTGLS 3461
Query: 71 IDWY-TDKLYWTDGETNKIEVISIVQKYRKVL 101
ID+ D++YW+D + + IE I R+V+
Sbjct: 3462 IDYLNNDRIYWSDFKEDVIETIKYDGTDRRVI 3493
Score = 41.5 bits (93), Expect = 0.018
Identities = 31/89 (34%), Positives = 34/89 (38%), Gaps = 30/89 (33%)
Query: 1097 CDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCI 1156
CDG DC D DE CG C+ AF C G CI
Sbjct: 271 CDGVDDCHDNSDEQLCGTLNNT--CSSS----------------------AFTCGHGECI 306
Query: 1157 AARFVCDGRPQCADGSDE------APAAC 1179
A + CD R C DGSDE APA+C
Sbjct: 307 PAHWRCDKRNDCVDGSDEHNCPTHAPASC 335
Score = 41.5 bits (93), Expect = 0.018
Identities = 29/108 (26%), Positives = 39/108 (36%), Gaps = 9/108 (8%)
Query: 1068 RVELARADNATALALDQSAGTVYWAVSRQCDGQQ-DCEDGRDEAECGACGGDVRCADGTX 1126
RV L DN D S + + C + C GR + C + C D +
Sbjct: 2064 RVYLCDGDNDCG---DNSDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASD 2120
Query: 1127 XXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
D F+CD G CI + ++CDG C D SDE
Sbjct: 2121 EPASCGHSERTCLA-----DEFKCDGGRCIPSEWICDGDNDCGDMSDE 2163
Score = 41.1 bits (92), Expect = 0.023
Identities = 31/90 (34%), Positives = 36/90 (40%), Gaps = 27/90 (30%)
Query: 1090 YWAVSRQCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFR 1149
YW +CDG DC DG DE E C DV C + FR
Sbjct: 3084 YW----KCDGDDDCGDGSDE-ELHLCL-DVPC---------------------NSPNRFR 3116
Query: 1150 CDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
CD CI + VC+G C DG+DE C
Sbjct: 3117 CDNNRCIYSHEVCNGVDDCGDGTDETEEHC 3146
Score = 40.7 bits (91), Expect = 0.031
Identities = 27/93 (29%), Positives = 33/93 (35%), Gaps = 13/93 (13%)
Query: 1096 QCDGQQDCEDGRDEAECGA--CG-GDVRCADGTXXXXX----------XXXXXXXXXXXX 1142
QCDGQ DC D DE C C + RC +
Sbjct: 2964 QCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRT 3023
Query: 1143 XXXDAFRCDEGLCIAARFVCDGRPQCADGSDEA 1175
+ F+C G C+ + CDG C D SDEA
Sbjct: 3024 CHPEYFQCTSGHCVHSELKCDGSADCLDASDEA 3056
Score = 39.9 bits (89), Expect = 0.054
Identities = 27/84 (32%), Positives = 31/84 (36%), Gaps = 21/84 (25%)
Query: 1096 QCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLC 1155
+CDG DC D DEA+C R DG F C +C
Sbjct: 3042 KCDGSADCLDASDEADC-----PTRFPDGAYCQATM----------------FECKNHVC 3080
Query: 1156 IAARFVCDGRPQCADGSDEAPAAC 1179
I + CDG C DGSDE C
Sbjct: 3081 IPPYWKCDGDDDCGDGSDEELHLC 3104
Score = 39.5 bits (88), Expect = 0.071
Identities = 27/125 (21%), Positives = 53/125 (42%), Gaps = 1/125 (0%)
Query: 631 VIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVEGLAIDWS 690
++ ++ V +LA LYW+DS K+I+ + +V++L + +
Sbjct: 3 ILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVVQYLNNPRSVVVHPF 62
Query: 691 GQNIYWTD-TTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKSIKR 749
+++TD +I + DGS +I L P + +D +YW + I+
Sbjct: 63 AGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEH 122
Query: 750 AAMDG 754
+ DG
Sbjct: 123 STFDG 127
Score = 39.5 bits (88), Expect = 0.071
Identities = 24/80 (30%), Positives = 39/80 (48%), Gaps = 3/80 (3%)
Query: 58 IVSEGLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPE 117
+++ L P G+AIDW +LYW D +KIE + R+ L E + +
Sbjct: 90 VINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIE-QMTHPFGLAIF 148
Query: 118 DGLMFWTDW--GEIPKIERA 135
+F+TDW G I ++ +A
Sbjct: 149 GEHLFFTDWRLGAIIRVRKA 168
Score = 39.5 bits (88), Expect = 0.071
Identities = 16/32 (50%), Positives = 17/32 (53%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F C G CI+ FVCD C DGSDE C
Sbjct: 2263 FTCQNGRCISKTFVCDEDNDCGDGSDELMHLC 2294
Score = 39.1 bits (87), Expect = 0.094
Identities = 23/73 (31%), Positives = 28/73 (38%), Gaps = 6/73 (8%)
Query: 1103 CEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVC 1162
C +GR +E C D C DG+ AF C G C+ + C
Sbjct: 1933 CSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPT------AFTCANGRCVQYSYRC 1986
Query: 1163 DGRPQCADGSDEA 1175
D C DGSDEA
Sbjct: 1987 DYYNDCGDGSDEA 1999
Score = 38.7 bits (86), Expect = 0.12
Identities = 17/47 (36%), Positives = 24/47 (51%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
N C NGGC+H C+ P +C CP + L D+ TC + +E
Sbjct: 577 NSCSDFNGGCTHECVQEPFGA----KCLCPLGFLLANDSKTCEDIDE 619
Score = 37.9 bits (84), Expect = 0.22
Identities = 23/77 (29%), Positives = 29/77 (37%), Gaps = 7/77 (9%)
Query: 1098 DGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIA 1157
D Q C++ + ++ C D C DG+ F C CI
Sbjct: 337 DTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQ-------FNCPNHRCID 389
Query: 1158 ARFVCDGRPQCADGSDE 1174
FVCDG C DGSDE
Sbjct: 390 LSFVCDGDKDCVDGSDE 406
Score = 37.9 bits (84), Expect = 0.22
Identities = 30/101 (29%), Positives = 38/101 (37%), Gaps = 16/101 (15%)
Query: 1096 QCDGQQDCEDGRDE-AECGA--CG-GDVRCADGTXXXXXXXXXXXXXXXXXXXXD----- 1146
+CDGQ+DC DG DE A C C G +C+DG D
Sbjct: 2757 KCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCE 2816
Query: 1147 -------AFRCDEGLCIAARFVCDGRPQCADGSDEAPAACA 1180
++C CI + CD C D SDE + CA
Sbjct: 2817 NHHCDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSSHCA 2857
Score = 37.9 bits (84), Expect = 0.22
Identities = 14/38 (36%), Positives = 20/38 (52%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAACAYGHTD 1185
F+C +G C + + +C+ C DGSDE C H D
Sbjct: 2784 FQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCD 2821
Score = 37.5 bits (83), Expect = 0.29
Identities = 19/44 (43%), Positives = 21/44 (47%), Gaps = 3/44 (6%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDE---APAACAYGHTDQVN 1188
FRC CI R+ CDG+ C D SDE AP C VN
Sbjct: 2951 FRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVN 2994
Score = 36.3 bits (80), Expect = 0.66
Identities = 23/90 (25%), Positives = 33/90 (36%), Gaps = 4/90 (4%)
Query: 1100 QQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAAR 1159
Q C++GR ++ C D C DG+ F+CD G CI
Sbjct: 2262 QFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHE----FKCDNGRCIEMM 2317
Query: 1160 FVCDGRPQCADGSDEAPAACAYGHTDQVNG 1189
+C+ C D SDE H ++G
Sbjct: 2318 KLCNHLDDCLDNSDEKGCGINECHDPSISG 2347
Score = 35.9 bits (79), Expect = 0.87
Identities = 25/77 (32%), Positives = 27/77 (35%), Gaps = 9/77 (11%)
Query: 1105 DGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDG 1164
D R + C GDV C DG + F C GLCI F CD
Sbjct: 2188 DRRCIPQSWVCDGDVDCTDG-------YDENQNCTRRTCSENEFTCGYGLCIPKIFRCDR 2240
Query: 1165 RPQCADGSDEAPAACAY 1181
C D SDE C Y
Sbjct: 2241 HNDCGDYSDE--RGCLY 2255
Score = 33.9 bits (74), Expect = 3.5
Identities = 12/29 (41%), Positives = 16/29 (55%)
Query: 1151 DEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
+ +CI ++CDG C D SDE P C
Sbjct: 2057 NSNICIPRVYLCDGDNDCGDNSDENPTYC 2085
Score = 33.5 bits (73), Expect = 4.7
Identities = 12/28 (42%), Positives = 16/28 (57%)
Query: 1147 AFRCDEGLCIAARFVCDGRPQCADGSDE 1174
+F C G C+ ++CDG C D SDE
Sbjct: 256 SFPCKNGRCVPNYYLCDGVDDCHDNSDE 283
Score = 33.1 bits (72), Expect = 6.2
Identities = 17/54 (31%), Positives = 25/54 (46%)
Query: 1039 LAFHQTKRYLIWNDVGRGAIMRANVDGTGRVELARADNATALALDQSAGTVYWA 1092
+AF R + ++D I DG+ R +AR A+ LD G +YWA
Sbjct: 1697 IAFDWITRRIYYSDYLNQMINSMAEDGSNRTVIARVPKPRAIVLDPCQGYLYWA 1750
>AC010740-1|AAY14689.1| 862|Homo sapiens unknown protein.
Length = 862
Score = 285 bits (700), Expect = 5e-76
Identities = 170/553 (30%), Positives = 275/553 (49%), Gaps = 27/553 (4%)
Query: 263 NNAGCSHLCLLSPDPPGYNCACPTGVKLR-ENSSTTCYDSPQMLLVVAQRSTISKISLDS 321
N+ CS +C C+C G KL + S T D + ++ + R I +I L
Sbjct: 296 NHLKCSQVC--EQHKHTVKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHK 353
Query: 322 PDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSD-----QSVVVRSS 376
D Y+L + L+ T+ +DF +YW D + I + +L S + VV
Sbjct: 354 RD---YSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGL 410
Query: 377 GVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFW 436
P+ + +D ++ IYW D +D I VA+LDGS +I + PRAIAL G +FW
Sbjct: 411 ATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFW 470
Query: 437 SDWNEKKPKIERANLDGSGRVLLISEKLT--WPNSIALDTVNNKLYWGDARTHKIEVCNM 494
+DW+ P+IE A++ G+GR + + T WPN + +D ++ W DAR+ I
Sbjct: 471 TDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALY 530
Query: 495 DGTERKELHSND--IIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMM 552
DGT E+ + H F + TL + NK TG + + + A
Sbjct: 531 DGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPF 590
Query: 553 GVKAFRLG-APLGWNPCA--DDNGGCSHLC-FNRPDDYICGCPLGLELTADKKTCVEPEA 608
++ + P NPCA D G CSH+C N C CP ++L++DKKTC E +
Sbjct: 591 DLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACPHLMKLSSDKKTCYEMKK 650
Query: 609 FLVYSRKNIIGRLSIKNEYNDAV--IPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCS 666
FL+Y+R++ I + I N Y + + + D+ +V+ + S +LYW+D KT+TI R
Sbjct: 651 FLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAF 710
Query: 667 VNGSAVEKIVEW-LGLVEGLAIDWSGQNIYW--TDTTTQRIEVSRLDGSSRRAIIWQGLK 723
+NG+ +E ++ + + GLA+DW +N+YW ++ +I V+RLDGS + +II G+
Sbjct: 711 INGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSII-HGID 769
Query: 724 KPKSIVLDPKKGYMYWSELGSKSIKRAAMDGSSVSVFMEQVGRVHALAIDYERRAIYWAA 783
KP+ + P +G +YW++ +I A MDGS+ + + L+IDY +YW +
Sbjct: 770 KPQCLAAHPVRGKLYWTD--GNTINMANMDGSNSKILFQNQKEPVGLSIDYVENKLYWIS 827
Query: 784 LDPPVVEFAFLNG 796
+ L+G
Sbjct: 828 SGNGTINRCNLDG 840
Score = 279 bits (685), Expect = 3e-74
Identities = 166/500 (33%), Positives = 262/500 (52%), Gaps = 26/500 (5%)
Query: 17 LEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSE-GLVTPTGIAIDWYT 75
L A+DFH+ ++L+ W+D + I +E+ ++V E GL TP G+ +DW
Sbjct: 363 LRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIA 422
Query: 76 DKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDW-GEIPKIER 134
+YW D ++IEV + R L ++ RAIA+ P G++FWTDW P+IE
Sbjct: 423 GNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIES 482
Query: 135 AGMNGDPATRKVIVRD--NIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVK 192
A M+G A RK I +D WPNG+TVD+ I W DA+ + ++G +++
Sbjct: 483 ASMSG--AGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIR 540
Query: 193 GG--LVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESR 250
G L +PFA++ ++YWTDW+ ++ + G + + K+ P D+++Y SR
Sbjct: 541 GHEYLSHPFAVSLYGSEVYWTDWRTNTLSKAN-KWTGQNVSVIQKTSAQPFDLQIYHPSR 599
Query: 251 QIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQ 310
Q + CSH+CL++ + CACP +KL + TCY+ + LL A+
Sbjct: 600 QPQAPNPCAANDGKGPCSHMCLINHNRSA-ACACPHLMKL-SSDKKTCYEMKKFLL-YAR 656
Query: 311 RSTISKISLDSPDF---TPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGS 367
RS I + +D+P F T +T+P D+ +DFD E +YW D +TI +A ++G+
Sbjct: 657 RSEIRGVDIDNPYFNFITAFTVP--DIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGT 714
Query: 368 D-QSVVVRSSGVPDSIAIDPLSRKIYWTDPVMD--TINVARLDGSYEKVIIHTELYDPRA 424
++V+ R +A+D +SR +YW D INVARLDGS + IIH + P+
Sbjct: 715 GLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSIIH-GIDKPQC 773
Query: 425 IALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDA 484
+A H G ++W+D N I AN+DGS +L + P +++D V NKLYW +
Sbjct: 774 LAAHPVRGKLYWTDGN----TINMANMDGSNSKILFQNQKE-PVGLSIDYVENKLYWISS 828
Query: 485 RTHKIEVCNMDGTERKELHS 504
I CN+DG + + S
Sbjct: 829 GNGTINRCNLDGGNLEVIES 848
Score = 230 bits (562), Expect = 3e-59
Identities = 155/543 (28%), Positives = 261/543 (48%), Gaps = 37/543 (6%)
Query: 575 CSHLCFNRPDDYICGCPLGLELTADKKTC--VEP-EAFLVYSRKNIIGRLSIKNEYNDAV 631
CS +C C C G +L D ++C V+P EAF+++S ++ I R+ + +
Sbjct: 300 CSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKRDYSLL 359
Query: 632 IPIKDLKEVSALALYVSGSKLYWSDSKTKTINR--CSVNG--SAVEKIVEW-LGLVEGLA 686
+P L+ AL + + S LYW+D I R S +G SA+E +VE L EGL
Sbjct: 360 VP--GLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLT 417
Query: 687 IDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSK- 745
+DW NIYW D+ +IEV++LDGS R +I ++ P++I LDP+ G ++W++ +
Sbjct: 418 VDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANF 477
Query: 746 -SIKRAAMDGSSVSVF---MEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQT 801
I+ A+M G+ M+ + L +D+ + I W + A +GT
Sbjct: 478 PRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIE 537
Query: 802 LA---DNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHR 858
+ + + P+A++L+ VYW DW T + +A K G N I+K DL++YH
Sbjct: 538 IIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHP 597
Query: 859 AKS-MGSNQCGVDN--GGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLF 915
++ N C ++ G CSH+CL + CACP +L+ D TC E ++FLL+
Sbjct: 598 SRQPQAPNPCAANDGKGPCSHMCLI---NHNRSAACACPHLMKLSSDKKTCYEMKKFLLY 654
Query: 916 AQKNAVGRIMVANGECN-DAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYX 974
A+++ + + + N N + + +V I++D E++LYW D + +I+R I+
Sbjct: 655 ARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFIN-- 712
Query: 975 XXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCA--DRDSINATSIDNNSSTGVIVRGD 1032
+ + +D + R +YW + D IN +D + T +I D
Sbjct: 713 ---GTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSIIHGID 769
Query: 1033 RMLPRHLAFHQTKRYLIWNDVGRGAIMRANVDGT-GRVELARADNATALALDQSAGTVYW 1091
+ P+ LA H + L W D I AN+DG+ ++ L++D +YW
Sbjct: 770 K--PQCLAAHPVRGKLYWTD--GNTINMANMDGSNSKILFQNQKEPVGLSIDYVENKLYW 825
Query: 1092 AVS 1094
S
Sbjct: 826 ISS 828
Score = 84.6 bits (200), Expect = 2e-15
Identities = 75/255 (29%), Positives = 120/255 (47%), Gaps = 19/255 (7%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKL-RENSSTTCYDSPQMLLVVAQRSTISKIS 318
C NN GCS+ C + P G C+CP G++L ++N + D L +Q K +
Sbjct: 252 CSLNNGGCSNHCSVVPG-RGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHT 310
Query: 319 LDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGV 378
+ + + L D+ DP +I ++ + I + L D S++V G+
Sbjct: 311 VKCSCYEGWKL---DVDGESCTSVDPFEAFIIFS--IRHEIRRIDLHKRDYSLLV--PGL 363
Query: 379 PDSIAIDPLSRK--IYWTDPVMDTINVARLDG----SYEKVIIHTELYDPRAIALHLTAG 432
++IA+D + +YWTD V D I +L S +V++ L P + + AG
Sbjct: 364 RNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAG 423
Query: 433 WMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYW--GDARTHKIE 490
++W D N +IE A LDGS R LI+ + P +IALD L+W DA +IE
Sbjct: 424 NIYWIDSN--LDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIE 481
Query: 491 VCNMDGTERKELHSN 505
+M G RK ++ +
Sbjct: 482 SASMSGAGRKTIYKD 496
Score = 75.8 bits (178), Expect = 9e-13
Identities = 73/297 (24%), Positives = 126/297 (42%), Gaps = 15/297 (5%)
Query: 568 CADDNGGCSHLCFNRPD-DYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGRLSIKNE 626
C+ +NGGCS+ C P +C CP GL+L D KTC + + + + + K+
Sbjct: 252 CSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCE-QHKHT 310
Query: 627 YNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVEGLA 686
+ L V + + S I R ++ +V L L
Sbjct: 311 VKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALD 370
Query: 687 IDWSGQNIYWTDTTTQRI---EVSRLDG-SSRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
++ +YWTD RI ++S G S+ ++ GL P+ + +D G +YW +
Sbjct: 371 FHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDS 430
Query: 743 GSKSIKRAAMDGS-SVSVFMEQVGRVHALAIDYERRAIYWAALDP--PVVEFAFLNGTGR 799
I+ A +DGS ++ + A+A+D ++W D P +E A ++G GR
Sbjct: 431 NLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGR 490
Query: 800 QTLADNI---PMPYALAL--FNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYIS 851
+T+ ++ P L + F + W D + I A DG+N I + +Y+S
Sbjct: 491 KTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSA-LYDGTNMIEIIRGHEYLS 546
Score = 65.3 bits (152), Expect = 1e-09
Identities = 40/158 (25%), Positives = 78/158 (49%), Gaps = 10/158 (6%)
Query: 16 DLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAIDWYT 75
D++ T +DF + + W+D K + I+ N TG + ++S + + G+A+DW +
Sbjct: 680 DIDDVTVIDFDASEERLYWTDIKTQTIKRAFING--TGLE-TVISRDIQSIRGLAVDWVS 736
Query: 76 DKLYWTDGETNKIEV-ISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIER 134
LYW E ++ ++ ++ + K +D + +A P G ++WTD I
Sbjct: 737 RNLYWISSEFDETQINVARLDGSLKTSIIHGIDKPQCLAAHPVRGKLYWTDGN---TINM 793
Query: 135 AGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDA 172
A M+G + I+ N P G+++DY + +YW+ +
Sbjct: 794 ANMDG---SNSKILFQNQKEPVGLSIDYVENKLYWISS 828
Score = 61.7 bits (143), Expect = 2e-08
Identities = 40/143 (27%), Positives = 72/143 (50%), Gaps = 8/143 (5%)
Query: 635 KDLKEVSALALYVSGSKLYWSDSK--TKTINRCSVNGSAVEKIVEWLGLVEGLAIDWSGQ 692
+D++ + LA+ LYW S+ IN ++GS I+ + + LA
Sbjct: 722 RDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSIIHGIDKPQCLAAHPVRG 781
Query: 693 NIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKSIKRAAM 752
+YWTD T I ++ +DGS+ + I++Q K+P + +D + +YW G+ +I R +
Sbjct: 782 KLYWTDGNT--INMANMDGSNSK-ILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCNL 838
Query: 753 DGSSVSV---FMEQVGRVHALAI 772
DG ++ V E++ + AL I
Sbjct: 839 DGGNLEVIESMKEELTKATALTI 861
Score = 52.8 bits (121), Expect = 7e-06
Identities = 54/232 (23%), Positives = 86/232 (37%), Gaps = 16/232 (6%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRI 924
++C ++NGGCS+ C PG C+CP +LNKDN TC + + + V
Sbjct: 250 DECSLNNGGCSNHCSVVPG---RGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQ 306
Query: 925 MVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXX 984
+C+ + DP E + + H IRR+ +
Sbjct: 307 HKHTVKCSCYEGWKLDVDGESCTSVDPFEAFIIF--SIRHEIRRIDLHKRDYSLLVPGLR 364
Query: 985 XXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNN---SSTGVIVRGDRMLPRHLAF 1041
L ++ L +YWT D I + + S+ V+V P L
Sbjct: 365 NTIALDFHFNQSL------LYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTV 418
Query: 1042 HQTKRYLIWNDVGRGAIMRANVDGTGRVEL--ARADNATALALDQSAGTVYW 1091
+ W D I A +DG+ R L ++ A+ALD G ++W
Sbjct: 419 DWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFW 470
Score = 43.2 bits (97), Expect = 0.006
Identities = 30/131 (22%), Positives = 61/131 (46%), Gaps = 9/131 (6%)
Query: 941 LKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVL 1000
++++R + D V + LYW+ + + + ++ G+ +P + +
Sbjct: 724 IQSIRGLAVDWVSRNLYWISSEFDETQ-INVA---RLDGSLKTSIIHGIDKPQCLAAHPV 779
Query: 1001 GRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGAIMR 1060
+YWT D ++IN ++D ++S I+ ++ P L+ + L W G G I R
Sbjct: 780 RGKLYWT--DGNTINMANMDGSNSK--ILFQNQKEPVGLSIDYVENKLYWISSGNGTINR 835
Query: 1061 ANVDGTGRVEL 1071
N+DG G +E+
Sbjct: 836 CNLDG-GNLEV 845
Score = 41.9 bits (94), Expect = 0.013
Identities = 24/78 (30%), Positives = 30/78 (38%), Gaps = 1/78 (1%)
Query: 1098 DGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCD-EGLCI 1156
D Q C GR AC GD C D + + F+C +G C+
Sbjct: 84 DNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCV 143
Query: 1157 AARFVCDGRPQCADGSDE 1174
+ CDG C DGSDE
Sbjct: 144 PDLWRCDGEKDCEDGSDE 161
Score = 40.7 bits (91), Expect = 0.031
Identities = 24/77 (31%), Positives = 29/77 (37%), Gaps = 9/77 (11%)
Query: 1103 CEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVC 1162
C+ GR + C D C DG+ + FRC G CI + C
Sbjct: 51 CKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFD---------NQFRCSSGRCIPGHWAC 101
Query: 1163 DGRPQCADGSDEAPAAC 1179
DG C D SDEA C
Sbjct: 102 DGDNDCGDFSDEAQINC 118
Score = 39.5 bits (88), Expect = 0.071
Identities = 28/80 (35%), Positives = 33/80 (41%), Gaps = 24/80 (30%)
Query: 1096 QCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRC-DEGL 1154
+CDG++DCEDG DE C G +R D F C G
Sbjct: 148 RCDGEKDCEDGSDEK---GCNGTIRLCD--------------------HKTKFSCWSTGR 184
Query: 1155 CIAARFVCDGRPQCADGSDE 1174
CI +VCDG C D SDE
Sbjct: 185 CINKAWVCDGDIDCEDQSDE 204
Score = 35.5 bits (78), Expect = 1.2
Identities = 13/27 (48%), Positives = 17/27 (62%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDE 1174
F C G CI++++ CD C DGSDE
Sbjct: 49 FVCKSGRCISSKWHCDSDDDCGDGSDE 75
Score = 35.1 bits (77), Expect = 1.5
Identities = 17/48 (35%), Positives = 29/48 (60%)
Query: 628 NDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKI 675
+++ I ++ KE L++ +KLYW S TINRC+++G +E I
Sbjct: 799 SNSKILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVI 846
Score = 34.3 bits (75), Expect = 2.7
Identities = 14/36 (38%), Positives = 19/36 (52%), Gaps = 1/36 (2%)
Query: 1146 DAFRCDEGLCIAARFVCDGRPQCADGSDEAPAACAY 1181
D F C G CI ++CD C D +DE A+C +
Sbjct: 6 DQFSCGNGRCIPRAWLCDREDDCGDQTDEM-ASCEF 40
>AF283342-1|AAL38107.1| 881|Homo sapiens candidate tumor suppressor
protein protein.
Length = 881
Score = 266 bits (653), Expect = 2e-70
Identities = 175/602 (29%), Positives = 293/602 (48%), Gaps = 27/602 (4%)
Query: 23 VDFHYRKNLICW--SDQKPELIQCMNYNET--YTGEKFKIVSEGLVTPTGIAIDWYTDKL 78
+DF Y +++ICW S + ++C+ + T E + + +AIDW T L
Sbjct: 238 LDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNL 297
Query: 79 YWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERAGMN 138
Y+ D ++I V + L E+ +AIAV P G +F+TD+G + K+ER M+
Sbjct: 298 YFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMD 357
Query: 139 GDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVKGGLV-Y 197
G TR I+ P + +D N L+YWVD L +V V+D+ G+ R V++G V +
Sbjct: 358 GMNRTR--IIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGKNRHTVIQGRQVRH 415
Query: 198 PFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESRQIISAED 257
+ +T D LY T+ N++I + NG I LIK I++Y + Q +
Sbjct: 416 LYGITVFEDYLYATNSDNYNIVRIN-RFNGTDIHSLIKIENAWG-IRIYQKRTQP-TVRS 472
Query: 258 YPCKKNN----AGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQR-- 311
+ C+ + GCSH+CLLS C C TG L + + ++ L +
Sbjct: 473 HACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSYKRPKNELFLFYGKGRP 532
Query: 312 STISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSV 371
+ + L++ Y +P+++L +DF +T YIY+AD + I + ++DG+++
Sbjct: 533 GIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGTERET 592
Query: 372 VVRSS-GVPDSIAIDPLSRKIYWT-DPVMDTINVARLDGSYE--KVIIHTELYDPRAIAL 427
+++ + IA+D + +YWT D TINVARL+ + + K ++ E+ PR I +
Sbjct: 593 ILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVV 652
Query: 428 HLTAGWMFWSDWNEKK-----PKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWG 482
GWM+W+DW E + +IE+A +DG R + ++ K+ WPN + LD N LYW
Sbjct: 653 DPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWC 712
Query: 483 DARTHKIEVCNMDGTERKELHS-NDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDR 541
DA IE ++GT RK ++S ++ H FG ++ +++ T +
Sbjct: 713 DAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDLITS-EV 771
Query: 542 QPVVEQMANMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKK 601
+ + + G++ + G N C +NGGCS LC P +C C L +
Sbjct: 772 TLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGT 831
Query: 602 TC 603
TC
Sbjct: 832 TC 833
Score = 251 bits (615), Expect = 1e-65
Identities = 213/776 (27%), Positives = 352/776 (45%), Gaps = 59/776 (7%)
Query: 205 NDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESRQIISAEDYPCKKNN 264
N L D + ++ ++ +N ++ K V + Y E I+ + CK +
Sbjct: 98 NGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQD 157
Query: 265 -----AGCSHLCLLSPDPPGYNCACPTGVKLR-ENSSTTCYDSPQ---MLLVVAQRSTIS 315
CS C + Y C+C G ++ +N S P +L++A TI
Sbjct: 158 ECAVYGTCSQTCRNTHG--SYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIE 215
Query: 316 KISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLA-----KTISKARLDG-SDQ 369
L+ TL + T+DF + I W + K I + G +D+
Sbjct: 216 VFYLNGSKMA--TLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDE 273
Query: 370 SVV--VRSSGVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIAL 427
+ ++S +AID L+R +Y+ D V D I V +GS +I EL++P+AIA+
Sbjct: 274 WTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAV 333
Query: 428 HLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTH 487
AG +F++D+ K+ER ++DG R +I K P ++ALD VN +YW D
Sbjct: 334 DPIAGKLFFTDYGNVA-KVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLD 392
Query: 488 KIEVCNMDGTERKE-LHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVE 546
+ V + G R + + H++G + RIN+ G D +++
Sbjct: 393 YVGVVDYQGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIK 452
Query: 547 QMANMMGVKAF--RLGAPLGWNPCADDN----GGCSHLCF--NRPDDYICGCPLGLELTA 598
+ N G++ + R + + C D GGCSH+C + C C G L +
Sbjct: 453 -IENAWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGS 511
Query: 599 DKKTCVEP--EAFLVYS--RKNIIGRLSIKNEYNDA-VIPIKDLKEVSALALYVSGSKLY 653
D ++ P E FL Y R I+ + + + D +IPI++L AL + + +Y
Sbjct: 512 DGRSYKRPKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIY 571
Query: 654 WSDSKTKTINRCSVNGSAVEKIV-EWLGLVEGLAIDWSGQNIYWT-DTTTQRIEVSRLD- 710
++D+ + I R ++G+ E I+ + L VEG+A+DW G N+YWT D + I V+RL+
Sbjct: 572 FADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEK 631
Query: 711 -GSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKSI-------KRAAMDGSSVSVFM- 761
SR+ ++ + P+ IV+DP G+MYW++ I ++A MDG + +F+
Sbjct: 632 ASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVT 691
Query: 762 EQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPM--PYALALFNDSV 819
++ + L +D+ +YW +E FLNGT R+ + + P+ L+ + V
Sbjct: 692 SKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYV 751
Query: 820 YWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCL 879
+W D+ G I Q S +R + + L++Y K G N C V+NGGCS LCL
Sbjct: 752 FWTDYMNGSIFQLDLIT-SEVTLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCL 810
Query: 880 PTPGDVRTDYRCACPAHYRLNKDNITCS-EPEEFLLFAQKNAVGRIMVANGECNDA 934
PG R CAC + L+++ TC+ P E L K G N C A
Sbjct: 811 AIPGG-RV---CACADNQLLDENGTTCTFNPGEALPHICK--AGEFRCKNRHCIQA 860
Score = 137 bits (331), Expect = 3e-31
Identities = 140/559 (25%), Positives = 231/559 (41%), Gaps = 50/559 (8%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTC---VEPE---AFLVYSRKNIIGRLSIKNE 626
G CS C N Y C C G + D ++C +EP L+ + I + N
Sbjct: 163 GTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETI-EVFYLNG 221
Query: 627 YNDAVIPIKDLKEVSALALYVSGSKLYWSDSKT-----KTINRCSVNGSAVE---KIVEW 678
A + + E+ L + + W +S+ K I G E I++
Sbjct: 222 SKMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQS 281
Query: 679 LGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMY 738
V+ +AIDW +N+Y+ D RI V +GS +I L PK+I +DP G ++
Sbjct: 282 FHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLF 341
Query: 739 WSELGS-KSIKRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNG 796
+++ G+ ++R MDG + + + + ALA+D + +YW L V G
Sbjct: 342 FTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQG 401
Query: 797 TGRQTLAD--NIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLK 854
R T+ + Y + +F D +Y + + I + + +G++ S+ K ++ ++
Sbjct: 402 KNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIK-IENAWGIR 460
Query: 855 LYHR--AKSMGSNQCGVD----NGGCSHLCLPTPG-DVRTDYRCACPAHYRLNKDNITCS 907
+Y + ++ S+ C VD GGCSH+CL + RT C C + L D +
Sbjct: 461 IYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRT---CRCRTGFNLGSDGRSYK 517
Query: 908 EPE-EFLLFAQKNAVG--RIMVANGECNDAY-IPLTGLKNVRAIEYDPVEKQLYWMDDDS 963
P+ E LF K G R M N + D Y IP+ L N RA+++ +Y+ D S
Sbjct: 518 RPKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTS 577
Query: 964 HSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWT-CADRDSINATSIDNN 1022
I R I L + +D +G +YWT R +IN ++
Sbjct: 578 FLIGRQKID-----GTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKA 632
Query: 1023 S-STGVIVRGDRMLPRHLAFHQTKRYLIWNDVGR-------GAIMRANVDGTGRVELARA 1074
S S ++ G+ PR + ++ W D G I +A +DG R +
Sbjct: 633 SQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTS 692
Query: 1075 DN--ATALALDQSAGTVYW 1091
L LD T+YW
Sbjct: 693 KMLWPNGLTLDFHTNTLYW 711
Score = 58.0 bits (134), Expect = 2e-07
Identities = 63/248 (25%), Positives = 86/248 (34%), Gaps = 19/248 (7%)
Query: 941 LKNVRAIEYDPVEKQLYWMD----DDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMV 996
+ + R I DPV +YW D + S+ R+ ++ + P +
Sbjct: 644 MSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSK--MLWPNGLT 701
Query: 997 LDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRG 1056
LD T+YW A D I + N + IV R L Y+ W D G
Sbjct: 702 LDFHTNTLYWCDAYYDHIEKVFL--NGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMNG 759
Query: 1057 AIMRANVDGTGRVELARADNATALALDQSAGTVYWAVSRQCDGQQDCEDGRDEAECGAC- 1115
+I + ++ T V L R + L +Y +Q D +G C A
Sbjct: 760 SIFQLDLI-TSEVTLLRHERPPLFGLQ-----IYDPRKQQGDNMCRVNNGGCSTLCLAIP 813
Query: 1116 GGDV-RCADGTXXXXXXXXXXXXXXXXXXX---XDAFRCDEGLCIAARFVCDGRPQCADG 1171
GG V CAD FRC CI AR+ CDG C DG
Sbjct: 814 GGRVCACADNQLLDENGTTCTFNPGEALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDG 873
Query: 1172 SDEAPAAC 1179
SDE C
Sbjct: 874 SDEDSVNC 881
Score = 34.7 bits (76), Expect = 2.0
Identities = 14/33 (42%), Positives = 19/33 (57%), Gaps = 1/33 (3%)
Query: 1148 FRC-DEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F C D C++ ++CDG P C D SDE+ C
Sbjct: 37 FLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTC 69
>AC073319-1|AAX93075.1| 585|Homo sapiens unknown protein.
Length = 585
Score = 235 bits (574), Expect = 9e-61
Identities = 147/500 (29%), Positives = 247/500 (49%), Gaps = 23/500 (4%)
Query: 121 MFWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVI 180
+F+TD+G + K+ER M+G TR I+ P + +D N L+YWVD L +V V+
Sbjct: 2 LFFTDYGNVAKVERCDMDGMNRTR--IIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVV 59
Query: 181 DFNGEKRKRVVKGGLV-YPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPV 239
D+ G+ R V++G V + + +T D LY T+ N++I + NG I LIK
Sbjct: 60 DYQGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRIN-RFNGTDIHSLIKIENA 118
Query: 240 PADIKVYDESRQIISAEDYPCKKNN----AGCSHLCLLSPDPPGYNCACPTGVKLRENSS 295
I++Y + Q + + C+ + GCSH+CLLS C C TG L +
Sbjct: 119 WG-IRIYQKRTQP-TVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGR 176
Query: 296 TTCYDSPQMLLVVAQR--STISKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWAD 353
+ ++ L + + + L++ Y +P+++L +DF +T YIY+AD
Sbjct: 177 SCKRPKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFAD 236
Query: 354 GLAKTISKARLDGSDQSVVVRSS-GVPDSIAIDPLSRKIYWT-DPVMDTINVARLDGSYE 411
+ I + ++DG+++ +++ + IA+D + +YWT D TINVARL+ + +
Sbjct: 237 TTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQ 296
Query: 412 --KVIIHTELYDPRAIALHLTAGWMFWSDWNEKK-----PKIERANLDGSGRVLLISEKL 464
K ++ E+ PR I + GWM+W+DW E + +IE+A +DG R + ++ K+
Sbjct: 297 SRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKM 356
Query: 465 TWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHS-NDIIHIFGXXXXXXXXXXX 523
WPN + LD N LYW DA IE ++GT RK ++S ++ H FG
Sbjct: 357 LWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWT 416
Query: 524 XMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRP 583
++ +++ T + + + + G++ + G N C +NGGCS LC P
Sbjct: 417 DYMNGSIFQLDLITS-EVTLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIP 475
Query: 584 DDYICGCPLGLELTADKKTC 603
+C C L + TC
Sbjct: 476 GGRVCACADNQLLDENGTTC 495
Score = 215 bits (524), Expect = 1e-54
Identities = 154/530 (29%), Positives = 252/530 (47%), Gaps = 38/530 (7%)
Query: 434 MFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCN 493
+F++D+ K+ER ++DG R +I K P ++ALD VN +YW D + V +
Sbjct: 2 LFFTDYGNVA-KVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVD 60
Query: 494 MDGTERKE-LHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMM 552
G R + + H++G + RIN+ G D +++ + N
Sbjct: 61 YQGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIK-IENAW 119
Query: 553 GVKAF--RLGAPLGWNPCADDN----GGCSHLCF--NRPDDYICGCPLGLELTADKKTCV 604
G++ + R + + C D GGCSH+C + C C G L +D ++C
Sbjct: 120 GIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCK 179
Query: 605 EP--EAFLVYS--RKNIIGRLSIKNEYNDA-VIPIKDLKEVSALALYVSGSKLYWSDSKT 659
P E FL Y R I+ + + + D +IPI++L AL + + +Y++D+ +
Sbjct: 180 RPKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTS 239
Query: 660 KTINRCSVNGSAVEKIV-EWLGLVEGLAIDWSGQNIYWT-DTTTQRIEVSRLD--GSSRR 715
I R ++G+ E I+ + L VEG+A+DW G N+YWT D + I V+RL+ SR+
Sbjct: 240 FLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRK 299
Query: 716 AIIWQGLKKPKSIVLDPKKGYMYWSELGSKSI-------KRAAMDGSSVSVFM-EQVGRV 767
++ + P+ IV+DP G+MYW++ I ++A MDG + +F+ ++
Sbjct: 300 TLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWP 359
Query: 768 HALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPM--PYALALFNDSVYWGDWN 825
+ L +D+ +YW +E FLNGT R+ + + P+ L+ + V+W D+
Sbjct: 360 NGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYM 419
Query: 826 TGQIQQARKTDGSNRKSIRKDLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDV 885
G I Q S +R + + L++Y K G N C V+NGGCS LCL PG
Sbjct: 420 NGSIFQLDLIT-SEVTLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGG- 477
Query: 886 RTDYRCACPAHYRLNKDNITCS-EPEEFLLFAQKNAVGRIMVANGECNDA 934
R CAC + L+++ TC+ P E L K G N C A
Sbjct: 478 RV---CACADNQLLDENGTTCTFNPGEALPHICK--AGEFRCKNRHCIQA 522
Score = 164 bits (399), Expect = 1e-39
Identities = 103/298 (34%), Positives = 152/298 (51%), Gaps = 23/298 (7%)
Query: 15 KDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAIDWY 74
++L A+DFH N I ++D LI + T E+ I+ + L GIA+DW
Sbjct: 215 ENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGT---ERETILKDDLDNVEGIAVDWI 271
Query: 75 TDKLYWT-DGETNKIEVISI--VQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGE--- 128
+ LYWT DG I V + + RK L E+ R I V P +G M+WTDW E
Sbjct: 272 GNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEI 331
Query: 129 ---IPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGE 185
+ +IE+A M+G R++ V + WPNG+T+D++ + +YW DA ++ + NG
Sbjct: 332 DDSVGRIEKAWMDG--FNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGT 389
Query: 186 KRKRVVKGG-LVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIK 244
RK V G L +PF L+ + ++WTD+ N SI+ D+ + ++ L P ++
Sbjct: 390 HRKIVYSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDLITS--EVTLLRHERPPLFGLQ 447
Query: 245 VYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSP 302
+YD +Q D C+ NN GCS LCL P G CAC L EN TTC +P
Sbjct: 448 IYDPRKQ---QGDNMCRVNNGGCSTLCLAIPG--GRVCACADNQLLDEN-GTTCTFNP 499
Score = 94.7 bits (225), Expect = 2e-18
Identities = 94/381 (24%), Positives = 161/381 (42%), Gaps = 35/381 (9%)
Query: 737 MYWSELGSKS-IKRAAMDGSS-VSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFL 794
+++++ G+ + ++R MDG + + + + ALA+D + +YW L V
Sbjct: 2 LFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDY 61
Query: 795 NGTGRQTLADN--IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISD 852
G R T+ + Y + +F D +Y + + I + + +G++ S+ K ++
Sbjct: 62 QGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIK-IENAWG 120
Query: 853 LKLYHRAK--SMGSNQCGVDN----GGCSHLCLPTPG-DVRTDYRCACPAHYRLNKDNIT 905
+++Y + ++ S+ C VD GGCSH+CL + RT C C + L D +
Sbjct: 121 IRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRT---CRCRTGFNLGSDGRS 177
Query: 906 CSEPE-EFLLFAQKNAVG--RIMVANGECNDAY-IPLTGLKNVRAIEYDPVEKQLYWMDD 961
C P+ E LF K G R M N + D Y IP+ L N RA+++ +Y+ D
Sbjct: 178 CKRPKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADT 237
Query: 962 DSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWT-CADRDSINATSID 1020
S I R I L + +D +G +YWT R +IN ++
Sbjct: 238 TSFLIGRQKID-----GTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLE 292
Query: 1021 NNS-STGVIVRGDRMLPRHLAFHQTKRYLIWNDVGR-------GAIMRANVDGTGRVELA 1072
S S ++ G+ PR + ++ W D G I +A +DG R
Sbjct: 293 KASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFV 352
Query: 1073 RADN--ATALALDQSAGTVYW 1091
+ L LD T+YW
Sbjct: 353 TSKMLWPNGLTLDFHTNTLYW 373
Score = 59.7 bits (138), Expect = 6e-08
Identities = 46/184 (25%), Positives = 82/184 (44%), Gaps = 10/184 (5%)
Query: 38 KPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKY 97
+P +++ M+ N T +++ I E LV P + T+ +Y+ D + I I
Sbjct: 193 RPGIVRGMDLN-TKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGTE 251
Query: 98 RKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNG 157
R+ + ++D IAV ++WT+ G I A + +RK ++ + P G
Sbjct: 252 RETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRG 311
Query: 158 ITVDYNNSLIYW-------VDAKLQFVDVIDFNGEKRKRVVKGGLVYPFALT--FSNDKL 208
I VD N +YW +D + ++ +G R+ V +++P LT F + L
Sbjct: 312 IVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTL 371
Query: 209 YWTD 212
YW D
Sbjct: 372 YWCD 375
Score = 58.4 bits (135), Expect = 1e-07
Identities = 64/253 (25%), Positives = 89/253 (35%), Gaps = 20/253 (7%)
Query: 941 LKNVRAIEYDPVEKQLYWMD----DDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMV 996
+ + R I DPV +YW D + S+ R+ ++ + P +
Sbjct: 306 MSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSK--MLWPNGLT 363
Query: 997 LDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRG 1056
LD T+YW A D I + N + IV R L Y+ W D G
Sbjct: 364 LDFHTNTLYWCDAYYDHIEKVFL--NGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMNG 421
Query: 1057 AIMRANVDGTGRVELARADNATALALDQSAGTVYWAVSRQCDGQQDCEDGRDEAECGAC- 1115
+I + ++ T V L R + L +Y +Q D +G C A
Sbjct: 422 SIFQLDLI-TSEVTLLRHERPPLFGLQ-----IYDPRKQQGDNMCRVNNGGCSTLCLAIP 475
Query: 1116 GGDV-RCADGTXXXXXXXXXXXXXXXXXXX---XDAFRCDEGLCIAARFVCDGRPQCADG 1171
GG V CAD FRC CI AR+ CDG C DG
Sbjct: 476 GGRVCACADNQLLDENGTTCTFNPGEALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDG 535
Query: 1172 SDEAPAACAYGHT 1184
SDE C + H+
Sbjct: 536 SDEDSVNC-FNHS 547
Score = 37.5 bits (83), Expect = 0.29
Identities = 13/34 (38%), Positives = 17/34 (50%)
Query: 1146 DAFRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
D F+C CI R++CDG C DE+ C
Sbjct: 551 DQFKCQNNRCIPKRWLCDGANDCGSNEDESNQTC 584
>AB209498-1|BAD92735.1| 2359|Homo sapiens low density
lipoprotein-related protein 1 variant protein.
Length = 2359
Score = 219 bits (534), Expect = 6e-56
Identities = 125/345 (36%), Positives = 191/345 (55%), Gaps = 19/345 (5%)
Query: 575 CSHLCFNRPDDYICGCPLGLELTA-DKKTC---VEPEAFLVYSRKNIIGRLSIKNEYNDA 630
CS C N Y C C G D +C + E FL+++ + + +L++ N
Sbjct: 808 CSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGS-NYT 866
Query: 631 VIPIKDLKEVSALALYVSGSKLYWSDSKTK--TINRCSVNGSAVEKIVEWLGLV--EGLA 686
++ + L AL +YW+D T+ I R +NGS V+ ++ GL +GLA
Sbjct: 867 LLK-QGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQ-VLHRTGLSNPDGLA 924
Query: 687 IDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS 746
+DW G N+YW D IEVS+L+G+ R ++ GL++P+++V+D + GY+YW++ G S
Sbjct: 925 VDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHS 984
Query: 747 -IKRAAMDGSSVSVFME-QVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQ-TLA 803
I R MDGSS SV ++ ++ + L +DY IYWA +EFA L+G+ R L+
Sbjct: 985 LIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLS 1044
Query: 804 DNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYH--RAKS 861
+IP +AL LF D VYW DW T I +A KT G+N+ + L DL ++H R
Sbjct: 1045 QDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPD 1104
Query: 862 MGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
+ ++ C V+NGGCS+LCL +PG ++CACP ++ L D TC
Sbjct: 1105 VPNHPCKVNNGGCSNLCLLSPGG---GHKCACPTNFYLGSDGRTC 1146
Score = 206 bits (503), Expect = 4e-52
Identities = 111/346 (32%), Positives = 182/346 (52%), Gaps = 14/346 (4%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLRENSSTTC--YDSPQMLLVVAQRSTISKISLDSPDF 324
CS C+ + Y C C G R +C + L+ A R + K++LD +
Sbjct: 808 CSQRCINTHG--SYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSN- 864
Query: 325 TPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAK--TISKARLDGSDQSVVVRSS-GVPDS 381
YTL + L + +DFD + + IYW D + I + L+GS+ V+ R+ PD
Sbjct: 865 --YTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDG 922
Query: 382 IAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNE 441
+A+D + +YW D DTI V++L+G+Y V++ + L +PRA+ + + G+++W+DW +
Sbjct: 923 LAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGD 982
Query: 442 KKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKE 501
I R +DGS R +++ K+TWPN + LD V ++YW DAR IE ++DG+ R
Sbjct: 983 HS-LIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHV 1041
Query: 502 LHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFR-LG 560
+ S DI HIF + ++++R +K TG ++ ++ + M + F L
Sbjct: 1042 VLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALR 1101
Query: 561 AP-LGWNPCADDNGGCSHLCFNRP-DDYICGCPLGLELTADKKTCV 604
P + +PC +NGGCS+LC P + C CP L +D +TCV
Sbjct: 1102 QPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCV 1147
Score = 197 bits (481), Expect = 2e-49
Identities = 109/289 (37%), Positives = 156/289 (53%), Gaps = 12/289 (4%)
Query: 11 TTIAKDLEQGTAVDFHYRKNLICWSDQKPE--LIQCMNYNETYTGEKFKIVSE-GLVTPT 67
T + + L A+DF YR+ +I W+D + +I+ M+ N G +++ GL P
Sbjct: 866 TLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLN----GSNVQVLHRTGLSNPD 921
Query: 68 GIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWG 127
G+A+DW LYW D + IEV + YR VL S + RA+ V ++G ++WTDWG
Sbjct: 922 GLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWG 981
Query: 128 EIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKR 187
+ I R GM+G ++R VIV I WPNG+T+DY IYW DA+ +++ +G R
Sbjct: 982 DHSLIGRIGMDG--SSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNR 1039
Query: 188 KRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYD 247
V+ + + FALT D +YWTDW+ SI G LI + P D+ V+
Sbjct: 1040 HVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAH-KTTGTNKTLLISTLHRPMDLHVFH 1098
Query: 248 ESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSST 296
RQ ++PCK NN GCS+LCLLSP G+ CACPT L + T
Sbjct: 1099 ALRQ-PDVPNHPCKVNNGGCSNLCLLSPG-GGHKCACPTNFYLGSDGRT 1145
Score = 153 bits (370), Expect = 5e-36
Identities = 89/243 (36%), Positives = 122/243 (50%), Gaps = 12/243 (4%)
Query: 62 GLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLM 121
GL P GIAIDW +YWTD + IEV + + RK L +D AI V P G M
Sbjct: 1771 GLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTM 1830
Query: 122 FWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVID 181
+W+DWG PKIE A M+G R+ +V+DNI WP G+ VDY+N +YW DAKL + I
Sbjct: 1831 YWSDWGNHPKIETAAMDG--TLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIR 1888
Query: 182 FNGEKRKRVV--KGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPV 239
NG K GL +PF++ D +Y + N ++ + P + L
Sbjct: 1889 LNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLV-NLTGGLSH 1947
Query: 240 PADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCY 299
+D+ +Y + +Q PC + C LCLLSP P C CP G +L +N +
Sbjct: 1948 ASDVVLYHQHKQ--PEVTNPCDRKK--CEWLCLLSPSGP--VCTCPNGKRL-DNGTCVPV 2000
Query: 300 DSP 302
SP
Sbjct: 2001 PSP 2003
Score = 135 bits (326), Expect = 1e-30
Identities = 102/360 (28%), Positives = 169/360 (46%), Gaps = 35/360 (9%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVY-SRKNIIGRLSIKNEYN--D 629
G CS LC N ++C C T + E ++Y + N I L + ++ +
Sbjct: 1647 GTCSQLCNNTKGGHLCSCARNFMKTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYE 1706
Query: 630 AVIPIKDLKEVSALALYVSGSKLYWSDSKTKTIN----------------RCSVNGSAVE 673
+ + A+ ++V ++YW++ T TI+ R ++
Sbjct: 1707 QAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTH 1766
Query: 674 KIVEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPK 733
+ L + G+AIDW N+YWTD+ IEV+++ G +R+ +I + +P +IV+DP
Sbjct: 1767 LNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPL 1826
Query: 734 KGYMYWSELGS-KSIKRAAMDGS-SVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEF 791
+G MYWS+ G+ I+ AAMDG+ ++ + + LA+DY +YWA V+
Sbjct: 1827 RGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGS 1886
Query: 792 AFLNGTGRQTLADN---IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLD 848
LNGT AD+ + P+++ +F D +Y + ++ + K S ++ L
Sbjct: 1887 IRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLS 1946
Query: 849 YISDLKLYHRAKSMG-SNQCGVDNGGCSHLCLPTP-GDVRTDYRCACPAHYRLNKDNITC 906
+ SD+ LYH+ K +N C D C LCL +P G V C CP RL DN TC
Sbjct: 1947 HASDVVLYHQHKQPEVTNPC--DRKKCEWLCLLSPSGPV-----CTCPNGKRL--DNGTC 1997
Score = 129 bits (311), Expect = 7e-29
Identities = 103/361 (28%), Positives = 177/361 (49%), Gaps = 33/361 (9%)
Query: 609 FLVYSRKNIIGRLSIKNE--YNDAVIPIKD---LKEVSALAL-YVSGS------KLYWSD 656
+L+YS + I+ + + +E N V P +D +K V ALA Y +G+ ++++SD
Sbjct: 16 YLLYSERTILKSIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSD 75
Query: 657 SKTKTINRCSVNGSAVEKIVEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLD----GS 712
I + + +GS IVE +G VEGLA +YWT TT I +D G+
Sbjct: 76 IHFGNIQQINDDGSRRITIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGA 135
Query: 713 SRR--AIIWQGLKKPKSIVLDPKKGYMYWSELGSK--SIKRAAMDGSSVSVFMEQVGRV- 767
R I G P++ VLD + M+W+ + SI RAA+ G++V +E+ R
Sbjct: 136 FERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTP 195
Query: 768 HALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPM-PYALALFNDSVYWGDWNT 826
+ LAID+ +Y++ +E +G+ R + + P+ P+ LA++ + ++W DW
Sbjct: 196 NGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVR 255
Query: 827 GQIQQARKTDGSNRKSIRKDLDY--ISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGD 884
+Q+A K GSN K +R D+ + + + + S + C ++NGGC LCL T
Sbjct: 256 RAVQRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLTH-- 313
Query: 885 VRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVANGECNDAYIPLTGLKNV 944
+ C+C R+ +D++TC + + A ANGEC + + G+ +
Sbjct: 314 -QGHVNCSCRGG-RILQDDLTCR-----AVNSSCRAQDEFECANGECINFSLTCDGVPHC 366
Query: 945 R 945
+
Sbjct: 367 K 367
Score = 118 bits (283), Expect = 2e-25
Identities = 91/318 (28%), Positives = 144/318 (45%), Gaps = 21/318 (6%)
Query: 306 LVVAQRSTISKISL-DSPDFTPYTLPLKD---LKRTLTVDFD------PKT-EYIYWADG 354
L+ ++R+ + I L D + P +D +K + + FD P T I+++D
Sbjct: 17 LLYSERTILKSIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDI 76
Query: 355 LAKTISKARLDGSDQSVVVRSSGVPDSIAIDPLSRKIYWTDPVMDTINVARLD----GSY 410
I + DGS + +V + G + +A +YWT TI +D G++
Sbjct: 77 HFGNIQQINDDGSRRITIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAF 136
Query: 411 EKVIIHTELYD--PRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPN 468
E+ + T D PRA L MFW++WNE+ P I RA L G+ + LI + + PN
Sbjct: 137 ERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPN 196
Query: 469 SIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXXXXXXXXXXMQKR 528
+A+D KLY+ DA KIE C DG+ R + ++ +H FG +R
Sbjct: 197 GLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRR 256
Query: 529 TLDRINKNTGLDRQPV-VEQMANMMGVKAFRLGA-PLGWNPCADDNGGCSHLCFNRPDDY 586
+ R NK+ G + + + V+ MG+ A +PC +NGGC LC +
Sbjct: 257 AVQRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLTHQGH 316
Query: 587 I-CGCPLGLELTADKKTC 603
+ C C G + D TC
Sbjct: 317 VNCSC-RGGRILQDDLTC 333
Score = 111 bits (268), Expect = 1e-23
Identities = 96/359 (26%), Positives = 151/359 (42%), Gaps = 30/359 (8%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDSPDFTP 326
CS LC + G+ C+C ++ +++ S +L +A + I + P +
Sbjct: 1649 CSQLC--NNTKGGHLCSCARNF-MKTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPH-SA 1704
Query: 327 YTLPLK--DLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGS-------------DQSV 371
Y + + R +D K +YW + TIS L + D+ V
Sbjct: 1705 YEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGV 1764
Query: 372 V-VRSSGV--PDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALH 428
+ SG+ P IAID ++ +YWTD D I VA++ G K +I + +P AI +
Sbjct: 1765 THLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVD 1824
Query: 429 LTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHK 488
G M+WSDW PKIE A +DG+ R L+ + + WP +A+D N +LYW DA+
Sbjct: 1825 PLRGTMYWSDWG-NHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSV 1883
Query: 489 IEVCNMDGTER--KELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVE 546
I ++GT+ + H F + +I+K +
Sbjct: 1884 IGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTG 1943
Query: 547 QMANMMGVKAF-RLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
+++ V + + P NPC D C LC P +C CP G L D TCV
Sbjct: 1944 GLSHASDVVLYHQHKQPEVTNPC--DRKKCEWLCLLSPSGPVCTCPNGKRL--DNGTCV 1998
Score = 104 bits (249), Expect = 2e-21
Identities = 73/258 (28%), Positives = 125/258 (48%), Gaps = 16/258 (6%)
Query: 53 GEKFKIVSEGLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQ------KYRKVLFWSEV 106
G + + E + + G+A D LYWT T+ I ++ Q + V+ S
Sbjct: 88 GSRRITIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGD 147
Query: 107 DLARAIAVVPEDGLMFWTDWGEI-PKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNS 165
D RA + LMFWT+W E P I RA ++G A ++ +I PNG+ +D+
Sbjct: 148 DHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSG--ANVLTLIEKDIRTPNGLAIDHRAE 205
Query: 166 LIYWVDAKLQFVDVIDFNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWD--I 223
+Y+ DA L ++ +++G R ++K V+PF L + ++WTDW ++ + +
Sbjct: 206 KLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHV 265
Query: 224 AANGPKIKELIKSHPVPADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCA 283
+N ++ I P+ I V +++ S E PC+ NN GC LCLL+ NC+
Sbjct: 266 GSNMKLLRVDIPQQPM-GIIAVANDTN---SCELSPCRINNGGCQDLCLLT-HQGHVNCS 320
Query: 284 CPTGVKLRENSSTTCYDS 301
C G L+++ + +S
Sbjct: 321 CRGGRILQDDLTCRAVNS 338
Score = 75.4 bits (177), Expect = 1e-12
Identities = 63/232 (27%), Positives = 102/232 (43%), Gaps = 22/232 (9%)
Query: 874 CSHLCLPTPGDVRTDYRCACPAHYR-LNKDNITC---SEPEEFLLFAQKNAVGRIMVANG 929
CS C+ T G Y+C C Y D +C ++ E FL+FA + + ++ N
Sbjct: 808 CSQRCINTHGS----YKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKL---NL 860
Query: 930 ECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHS--IRRVPISYXXXXXXXXXXXXXX 987
+ ++ + GL N A+++D E+ +YW D + IRR+ ++
Sbjct: 861 DGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLN-----GSNVQVLHRT 915
Query: 988 GLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRY 1047
GLS P + +D +G +YW RD+I + + N + V+V PR L Y
Sbjct: 916 GLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKL-NGAYRTVLVSSGLREPRALVVDVQNGY 974
Query: 1048 LIWNDVG-RGAIMRANVDGTGRVEL--ARADNATALALDQSAGTVYWAVSRQ 1096
L W D G I R +DG+ R + + L LD +YWA +R+
Sbjct: 975 LYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADARE 1026
Score = 64.9 bits (151), Expect = 2e-09
Identities = 48/186 (25%), Positives = 82/186 (44%), Gaps = 11/186 (5%)
Query: 35 SDQKPELIQCMNY---NETYTGEKFKIVSEGLVTPTGIAIDWYTDKLYWTDGET--NKIE 89
+D++P LI Y G + ++ +GL + D+ +YWTD T + I
Sbjct: 841 TDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIR 900
Query: 90 VISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERAGMNGDPATRKVIVR 149
+ + +VL + + +AV G ++W D G IE + +NG A R V+V
Sbjct: 901 RMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGR-DTIEVSKLNG--AYRTVLVS 957
Query: 150 DNIFWPNGITVDYNNSLIYWVD-AKLQFVDVIDFNGEKRKRVVKGGLVYPFALT--FSND 206
+ P + VD N +YW D + I +G R +V + +P LT + +
Sbjct: 958 SGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTE 1017
Query: 207 KLYWTD 212
++YW D
Sbjct: 1018 RIYWAD 1023
Score = 56.4 bits (130), Expect = 6e-07
Identities = 60/252 (23%), Positives = 92/252 (36%), Gaps = 18/252 (7%)
Query: 933 DAYIPLTGLKNVRAIEYDPVEKQLYWMD-DDSH-SIRRVPISYXXXXXXXXXXXXXXGLS 990
+ I ++G + RA D + ++W + ++ H SI R +S +
Sbjct: 139 ETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALS-----GANVLTLIEKDIR 193
Query: 991 RPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIW 1050
P + +D +Y++ A D I D S VI++ + + P LA + ++ W
Sbjct: 194 TPNGLAIDHRAEKLYFSDATLDKIERCEYDG-SHRYVILKSEPVHPFGLAVYG--EHIFW 250
Query: 1051 NDVGRGAIMRANVDGTGRVELARADNATALALDQSAGTVYWAVSRQCDGQQDCE--DGRD 1108
D R A+ RAN ++L R D Q G + A C +G
Sbjct: 251 TDWVRRAVQRANKHVGSNMKLLRVDIP-----QQPMGIIAVANDTNSCELSPCRINNGGC 305
Query: 1109 EAECGACG-GDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQ 1167
+ C G V C+ D F C G CI CDG P
Sbjct: 306 QDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFECANGECINFSLTCDGVPH 365
Query: 1168 CADGSDEAPAAC 1179
C D SDE P+ C
Sbjct: 366 CKDKSDEKPSYC 377
Score = 52.0 bits (119), Expect = 1e-05
Identities = 49/170 (28%), Positives = 60/170 (35%), Gaps = 8/170 (4%)
Query: 923 RIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXX 982
R M NG N + TGL N + D V LYW D R I
Sbjct: 900 RRMHLNGS-NVQVLHRTGLSNPDGLAVDWVGGNLYWCDKG-----RDTIEVSKLNGAYRT 953
Query: 983 XXXXXGLSRPYHMVLDVLGRTMYWT-CADRDSINATSIDNNSSTGVIVRGDRMLPRHLAF 1041
GL P +V+DV +YWT D I +D SS VIV P L
Sbjct: 954 VLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDG-SSRSVIVDTKITWPNGLTL 1012
Query: 1042 HQTKRYLIWNDVGRGAIMRANVDGTGRVELARADNATALALDQSAGTVYW 1091
+ W D I A++DG+ R + D AL VYW
Sbjct: 1013 DYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYW 1062
Score = 50.8 bits (116), Expect = 3e-05
Identities = 33/100 (33%), Positives = 38/100 (38%), Gaps = 16/100 (16%)
Query: 1096 QCDGQQDCEDGRDEAECGA---------CGGDVRC------ADGTXXXXXXXXXXXXXXX 1140
+C+GQ +C DG DE +C C RC D
Sbjct: 1248 RCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQ 1307
Query: 1141 XXXXXDAFRC-DEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
D FRC D G CI AR+ CDG C DGSDE C
Sbjct: 1308 MTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEEC 1347
Score = 48.4 bits (110), Expect = 2e-04
Identities = 39/114 (34%), Positives = 42/114 (36%), Gaps = 30/114 (26%)
Query: 1093 VSRQ--CDGQQDCEDGRDEAE------CGA-----------------CGGDVRCADGTXX 1127
+S+Q CDG DC DG DEA CG C GD CADG
Sbjct: 563 ISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADE 622
Query: 1128 XXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAACAY 1181
F C CI FVCD CADGSDE+P C Y
Sbjct: 623 SIAAGCLYNSTCDDRE----FMCQNRQCIPKHFVCDHDRDCADGSDESP-ECEY 671
Score = 48.0 bits (109), Expect = 2e-04
Identities = 30/99 (30%), Positives = 35/99 (35%), Gaps = 14/99 (14%)
Query: 1096 QCDGQQDCEDGRDEAECGA-CGGDV-------------RCADGTXXXXXXXXXXXXXXXX 1141
+CDG DC DG DE +C C D RC
Sbjct: 1409 KCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVR 1468
Query: 1142 XXXXDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAACA 1180
D F+C+ LC + CDG C D SDE P CA
Sbjct: 1469 TCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECA 1507
Score = 47.2 bits (107), Expect = 4e-04
Identities = 32/107 (29%), Positives = 43/107 (40%), Gaps = 15/107 (14%)
Query: 1093 VSRQCDGQQDCEDGRDEAECGACGGDV-------RC------ADGTXXXXXXXXXXXXXX 1139
+S CD + DCE G DE C + RC DG+
Sbjct: 527 MSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCE 586
Query: 1140 XXXXXXDAFRCD-EGLCIAARFVCDGRPQCADGSDEAPAA-CAYGHT 1184
+F C +C+ R++CDG CADG+DE+ AA C Y T
Sbjct: 587 GKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNST 633
Score = 43.6 bits (98), Expect = 0.004
Identities = 32/95 (33%), Positives = 36/95 (37%), Gaps = 17/95 (17%)
Query: 1096 QCDGQQDCEDGRDEA--ECGA---------CGGDVRCADGTXXXXXXXXXXXXXXXXXXX 1144
+CDG+ DC DG DE EC C + RC G
Sbjct: 1329 KCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNN-RCVPGRWQCDYDNDCGDNSDEESCT 1387
Query: 1145 -----XDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
F C G CIA R+ CDG CADGSDE
Sbjct: 1388 PRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDE 1422
Score = 40.7 bits (91), Expect = 0.031
Identities = 33/101 (32%), Positives = 37/101 (36%), Gaps = 23/101 (22%)
Query: 1097 CDGQQDCEDGRDEAECG--ACG-GDVRCADGTXXXXXX---------XXXXXXXXXXXXX 1144
C+G DC DG DE C ACG G+ RC DGT
Sbjct: 401 CNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDC 460
Query: 1145 XDAFR----------CDE-GLCIAARFVCDGRPQCADGSDE 1174
FR C+ LC A +VCDG C D SDE
Sbjct: 461 SSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDE 501
Score = 38.7 bits (86), Expect = 0.12
Identities = 29/100 (29%), Positives = 38/100 (38%), Gaps = 22/100 (22%)
Query: 1097 CDGQQDCEDGRDEA-ECG--ACG-GDVRCADGTXXXXXXXXXXXXXXXXXXXXDA----- 1147
CD +DC DG DE+ EC CG + RCA+G +A
Sbjct: 653 CDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPH 712
Query: 1148 -------------FRCDEGLCIAARFVCDGRPQCADGSDE 1174
F C G C+A +C+G+ C D SDE
Sbjct: 713 CTSPEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDE 752
Score = 38.7 bits (86), Expect = 0.12
Identities = 14/28 (50%), Positives = 17/28 (60%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEA 1175
F+C G+C F+CDG C D SDEA
Sbjct: 1195 FQCSTGICTNPAFICDGDNDCQDNSDEA 1222
Score = 38.3 bits (85), Expect = 0.16
Identities = 33/139 (23%), Positives = 53/139 (38%), Gaps = 7/139 (5%)
Query: 935 YIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYH 994
++ ++GLK R I D V +YW D R I + P+
Sbjct: 1766 HLNISGLKMPRGIAIDWVAGNVYWTDSG-----RDVIEVAQMKGENRKTLISGMIDEPHA 1820
Query: 995 MVLDVLGRTMYWT-CADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDV 1053
+V+D L TMYW+ + I ++D + +V+ + P LA L W D
Sbjct: 1821 IVVDPLRGTMYWSDWGNHPKIETAAMD-GTLRETLVQDNIQWPTGLAVDYHNERLYWADA 1879
Query: 1054 GRGAIMRANVDGTGRVELA 1072
I ++GT + A
Sbjct: 1880 KLSVIGSIRLNGTDPIVAA 1898
Score = 37.9 bits (84), Expect = 0.22
Identities = 16/30 (53%), Positives = 20/30 (66%), Gaps = 1/30 (3%)
Query: 1148 FRCDEGLCIAAR-FVCDGRPQCADGSDEAP 1176
FRC G C+++R + CDG C D SDEAP
Sbjct: 679 FRCANGRCLSSRQWECDGENDCHDQSDEAP 708
Score = 36.7 bits (81), Expect = 0.50
Identities = 25/82 (30%), Positives = 29/82 (35%), Gaps = 6/82 (7%)
Query: 1107 RDEAEC--GACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFR-CDEGLCIAARFVCD 1163
+DE EC G C DG FR C G C++ C+
Sbjct: 343 QDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCN 402
Query: 1164 GRPQCADGSDEAP---AACAYG 1182
G C DGSDE P AC G
Sbjct: 403 GADDCGDGSDEIPCNKTACGVG 424
Score = 35.9 bits (79), Expect = 0.87
Identities = 12/36 (33%), Positives = 24/36 (66%)
Query: 58 IVSEGLVTPTGIAIDWYTDKLYWTDGETNKIEVISI 93
+V + + PTG+A+D++ ++LYW D + + I I +
Sbjct: 1854 LVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRL 1889
Score = 35.1 bits (77), Expect = 1.5
Identities = 19/60 (31%), Positives = 27/60 (45%), Gaps = 2/60 (3%)
Query: 1035 LPRHLAFHQTKRYLIWNDVGRGAIMRANVDGTGRVELARA--DNATALALDQSAGTVYWA 1092
+PR +A + W D GR I A + G R L D A+ +D GT+YW+
Sbjct: 1774 MPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWS 1833
Score = 34.7 bits (76), Expect = 2.0
Identities = 32/113 (28%), Positives = 36/113 (31%), Gaps = 20/113 (17%)
Query: 1097 CDGQQDCEDGRDE-AECG--ACGGD-VRCADGTXXXXXXXXXXXXXXXXXXXXDA----- 1147
CD DC DG DE A C CG D RC D +
Sbjct: 1289 CDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECD 1348
Query: 1148 --------FRCDEGLCIAARFVCDGRPQCADGSDE---APAACAYGHTDQVNG 1189
FRC C+ R+ CD C D SDE P C+ NG
Sbjct: 1349 ERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANG 1401
Score = 33.5 bits (73), Expect = 4.7
Identities = 11/20 (55%), Positives = 14/20 (70%)
Query: 1093 VSRQCDGQQDCEDGRDEAEC 1112
+ RQCDG +C DG DE +C
Sbjct: 1528 IGRQCDGTDNCGDGTDEEDC 1547
Score = 33.1 bits (72), Expect = 6.2
Identities = 33/173 (19%), Positives = 60/173 (34%), Gaps = 4/173 (2%)
Query: 922 GRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXX-XXXXX 980
G I N + + + + +V + Y LYW + +I R +
Sbjct: 79 GNIQQINDDGSRRITIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFER 138
Query: 981 XXXXXXXGLSRPYHMVLDVLGRTMYWTCADRD--SINATSIDNNSSTGVIVRGDRMLPRH 1038
G P VLD M+WT + SI ++ + ++ ++ D P
Sbjct: 139 ETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAAL-SGANVLTLIEKDIRTPNG 197
Query: 1039 LAFHQTKRYLIWNDVGRGAIMRANVDGTGRVELARADNATALALDQSAGTVYW 1091
LA L ++D I R DG+ R + +++ L ++W
Sbjct: 198 LAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFW 250
>AK054663-1|BAB70786.1| 820|Homo sapiens umor (LRPDIT) mRNA.
protein.
Length = 820
Score = 214 bits (523), Expect = 1e-54
Identities = 131/423 (30%), Positives = 205/423 (48%), Gaps = 21/423 (4%)
Query: 263 NNAGCSHLCLLSPDPPGYNCACPTGVKLR-ENSSTTCYDSPQMLLVVAQRSTISKISLDS 321
N+ CS +C C+C G KL + S T D + ++ + R I +I L
Sbjct: 403 NHLKCSQVC--EQHKHTVKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHK 460
Query: 322 PDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSD-----QSVVVRSS 376
D Y+L + L+ T+ +DF +YW D + I + +L S + VV
Sbjct: 461 RD---YSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGL 517
Query: 377 GVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFW 436
P+ + +D ++ IYW D +D I VA+LDGS +I + PRAIAL G +FW
Sbjct: 518 ATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFW 577
Query: 437 SDWNEKKPKIERANLDGSGRVLLISEKLT--WPNSIALDTVNNKLYWGDARTHKIEVCNM 494
+DW+ P+IE A++ G+GR + + T WPN + +D ++ W DAR+ I
Sbjct: 578 TDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALY 637
Query: 495 DGTERKELHSND--IIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMM 552
DGT E+ + H F + TL + NK TG + + + A
Sbjct: 638 DGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPF 697
Query: 553 GVKAFRLG-APLGWNPCA--DDNGGCSHLC-FNRPDDYICGCPLGLELTADKKTCVEPEA 608
++ + P NPCA D G CSH+C N C CP ++L++DKKTC E +
Sbjct: 698 DLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACPHLMKLSSDKKTCYEMKK 757
Query: 609 FLVYSRKNIIGRLSIKNEYNDAV--IPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCS 666
FL+Y+R++ I + I N Y + + + D+ +V+ + S +LYW+D KT+TI R
Sbjct: 758 FLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAF 817
Query: 667 VNG 669
+NG
Sbjct: 818 ING 820
Score = 205 bits (501), Expect = 6e-52
Identities = 117/359 (32%), Positives = 188/359 (52%), Gaps = 17/359 (4%)
Query: 17 LEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSE-GLVTPTGIAIDWYT 75
L A+DFH+ ++L+ W+D + I +E+ ++V E GL TP G+ +DW
Sbjct: 470 LRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIA 529
Query: 76 DKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDW-GEIPKIER 134
+YW D ++IEV + R L ++ RAIA+ P G++FWTDW P+IE
Sbjct: 530 GNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIES 589
Query: 135 AGMNGDPATRKVIVRD--NIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVK 192
A M+G A RK I +D WPNG+TVD+ I W DA+ + ++G +++
Sbjct: 590 ASMSG--AGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIR 647
Query: 193 GG--LVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESR 250
G L +PFA++ ++YWTDW+ ++ + G + + K+ P D+++Y SR
Sbjct: 648 GHEYLSHPFAVSLYGSEVYWTDWRTNTLSKAN-KWTGQNVSVIQKTSAQPFDLQIYHPSR 706
Query: 251 QIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQ 310
Q + CSH+CL++ + CACP +KL + TCY+ + LL A+
Sbjct: 707 QPQAPNPCAANDGKGPCSHMCLINHNRSA-ACACPHLMKL-SSDKKTCYEMKKFLL-YAR 763
Query: 311 RSTISKISLDSPDF---TPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDG 366
RS I + +D+P F T +T+P D+ +DFD E +YW D +TI +A ++G
Sbjct: 764 RSEIRGVDIDNPYFNFITAFTVP--DIDDVTVIDFDASEERLYWTDIKTQTIKRAFING 820
Score = 204 bits (497), Expect = 2e-51
Identities = 127/418 (30%), Positives = 216/418 (51%), Gaps = 25/418 (5%)
Query: 575 CSHLCFNRPDDYICGCPLGLELTADKKTC--VEP-EAFLVYSRKNIIGRLSIKNEYNDAV 631
CS +C C C G +L D ++C V+P EAF+++S ++ I R+ + +
Sbjct: 407 CSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKRDYSLL 466
Query: 632 IPIKDLKEVSALALYVSGSKLYWSDSKTKTINR--CSVNG--SAVEKIVEW-LGLVEGLA 686
+P L+ AL + + S LYW+D I R S +G SA+E +VE L EGL
Sbjct: 467 VP--GLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLT 524
Query: 687 IDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSK- 745
+DW NIYW D+ +IEV++LDGS R +I ++ P++I LDP+ G ++W++ +
Sbjct: 525 VDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANF 584
Query: 746 -SIKRAAMDGS---SVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQT 801
I+ A+M G+ ++ M+ + L +D+ + I W + A +GT
Sbjct: 585 PRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIE 644
Query: 802 LA---DNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHR 858
+ + + P+A++L+ VYW DW T + +A K G N I+K DL++YH
Sbjct: 645 IIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHP 704
Query: 859 AKS-MGSNQCGVDN--GGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLF 915
++ N C ++ G CSH+CL + CACP +L+ D TC E ++FLL+
Sbjct: 705 SRQPQAPNPCAANDGKGPCSHMCLI---NHNRSAACACPHLMKLSSDKKTCYEMKKFLLY 761
Query: 916 AQKNAVGRIMVANGECN-DAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPIS 972
A+++ + + + N N + + +V I++D E++LYW D + +I+R I+
Sbjct: 762 ARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFIN 819
Score = 84.6 bits (200), Expect = 2e-15
Identities = 75/255 (29%), Positives = 120/255 (47%), Gaps = 19/255 (7%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKL-RENSSTTCYDSPQMLLVVAQRSTISKIS 318
C NN GCS+ C + P G C+CP G++L ++N + D L +Q K +
Sbjct: 359 CSLNNGGCSNHCSVVPG-RGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHT 417
Query: 319 LDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGV 378
+ + + L D+ DP +I ++ + I + L D S++V G+
Sbjct: 418 VKCSCYEGWKL---DVDGESCTSVDPFEAFIIFS--IRHEIRRIDLHKRDYSLLV--PGL 470
Query: 379 PDSIAIDPLSRK--IYWTDPVMDTINVARLDG----SYEKVIIHTELYDPRAIALHLTAG 432
++IA+D + +YWTD V D I +L S +V++ L P + + AG
Sbjct: 471 RNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAG 530
Query: 433 WMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYW--GDARTHKIE 490
++W D N +IE A LDGS R LI+ + P +IALD L+W DA +IE
Sbjct: 531 NIYWIDSN--LDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIE 588
Query: 491 VCNMDGTERKELHSN 505
+M G RK ++ +
Sbjct: 589 SASMSGAGRKTIYKD 603
Score = 75.8 bits (178), Expect = 9e-13
Identities = 73/297 (24%), Positives = 126/297 (42%), Gaps = 15/297 (5%)
Query: 568 CADDNGGCSHLCFNRPD-DYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGRLSIKNE 626
C+ +NGGCS+ C P +C CP GL+L D KTC + + + + + K+
Sbjct: 359 CSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCE-QHKHT 417
Query: 627 YNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVEGLA 686
+ L V + + S I R ++ +V L L
Sbjct: 418 VKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALD 477
Query: 687 IDWSGQNIYWTDTTTQRI---EVSRLDG-SSRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
++ +YWTD RI ++S G S+ ++ GL P+ + +D G +YW +
Sbjct: 478 FHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDS 537
Query: 743 GSKSIKRAAMDGS-SVSVFMEQVGRVHALAIDYERRAIYWAALDP--PVVEFAFLNGTGR 799
I+ A +DGS ++ + A+A+D ++W D P +E A ++G GR
Sbjct: 538 NLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGR 597
Query: 800 QTLADNI---PMPYALAL--FNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYIS 851
+T+ ++ P L + F + W D + I A DG+N I + +Y+S
Sbjct: 598 KTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSA-LYDGTNMIEIIRGHEYLS 653
Score = 52.8 bits (121), Expect = 7e-06
Identities = 54/232 (23%), Positives = 86/232 (37%), Gaps = 16/232 (6%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRI 924
++C ++NGGCS+ C PG C+CP +LNKDN TC + + + V
Sbjct: 357 DECSLNNGGCSNHCSVVPG---RGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQ 413
Query: 925 MVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXX 984
+C+ + DP E + + H IRR+ +
Sbjct: 414 HKHTVKCSCYEGWKLDVDGESCTSVDPFEAFIIF--SIRHEIRRIDLHKRDYSLLVPGLR 471
Query: 985 XXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNN---SSTGVIVRGDRMLPRHLAF 1041
L ++ L +YWT D I + + S+ V+V P L
Sbjct: 472 NTIALDFHFNQSL------LYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTV 525
Query: 1042 HQTKRYLIWNDVGRGAIMRANVDGTGRVEL--ARADNATALALDQSAGTVYW 1091
+ W D I A +DG+ R L ++ A+ALD G ++W
Sbjct: 526 DWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFW 577
Score = 41.9 bits (94), Expect = 0.013
Identities = 24/78 (30%), Positives = 30/78 (38%), Gaps = 1/78 (1%)
Query: 1098 DGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCD-EGLCI 1156
D Q C GR AC GD C D + + F+C +G C+
Sbjct: 191 DNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCV 250
Query: 1157 AARFVCDGRPQCADGSDE 1174
+ CDG C DGSDE
Sbjct: 251 PDLWRCDGEKDCEDGSDE 268
Score = 40.7 bits (91), Expect = 0.031
Identities = 24/77 (31%), Positives = 29/77 (37%), Gaps = 9/77 (11%)
Query: 1103 CEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVC 1162
C+ GR + C D C DG+ + FRC G CI + C
Sbjct: 158 CKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFD---------NQFRCSSGRCIPGHWAC 208
Query: 1163 DGRPQCADGSDEAPAAC 1179
DG C D SDEA C
Sbjct: 209 DGDNDCGDFSDEAQINC 225
Score = 39.5 bits (88), Expect = 0.071
Identities = 28/80 (35%), Positives = 33/80 (41%), Gaps = 24/80 (30%)
Query: 1096 QCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRC-DEGL 1154
+CDG++DCEDG DE C G +R D F C G
Sbjct: 255 RCDGEKDCEDGSDEK---GCNGTIRSCD--------------------HKTKFSCWSTGR 291
Query: 1155 CIAARFVCDGRPQCADGSDE 1174
CI +VCDG C D SDE
Sbjct: 292 CINKAWVCDGDIDCEDQSDE 311
Score = 36.3 bits (80), Expect = 0.66
Identities = 31/157 (19%), Positives = 53/157 (33%), Gaps = 10/157 (6%)
Query: 940 GLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDV 999
GL + D + +YW+D + I + + P + LD
Sbjct: 516 GLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLD-----GSLRTTLIAGAMEHPRAIALDP 570
Query: 1000 LGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRML---PRHLAFHQTKRYLIWNDVGRG 1056
++WT D + S + + + D P L ++ ++W D
Sbjct: 571 RYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSD 630
Query: 1057 AIMRANVDGTGRVELARADN--ATALALDQSAGTVYW 1091
AI A DGT +E+ R + A+ VYW
Sbjct: 631 AIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYW 667
Score = 35.9 bits (79), Expect = 0.87
Identities = 24/82 (29%), Positives = 30/82 (36%), Gaps = 7/82 (8%)
Query: 1094 SRQCDGQQ-DCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDE 1152
SR C Q C +GR C + C D T F C
Sbjct: 107 SRTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQ------FVCKS 160
Query: 1153 GLCIAARFVCDGRPQCADGSDE 1174
G CI++++ CD C DGSDE
Sbjct: 161 GRCISSKWHCDSDDDCGDGSDE 182
Score = 33.1 bits (72), Expect = 6.2
Identities = 13/29 (44%), Positives = 18/29 (62%), Gaps = 1/29 (3%)
Query: 1148 FRC-DEGLCIAARFVCDGRPQCADGSDEA 1175
F C D C++ ++CDG P C D SDE+
Sbjct: 75 FLCHDHVTCVSQSWLCDGDPDCPDDSDES 103
>AF283408-1|AAL38109.1| 1537|Homo sapiens candidate tumor suppressor
protein protein.
Length = 1537
Score = 211 bits (516), Expect = 1e-53
Identities = 124/344 (36%), Positives = 188/344 (54%), Gaps = 20/344 (5%)
Query: 575 CSHLCFNRPDDYICGCPLGLELTADK----KTCVEPEAFLVYSRKNIIGRLSIKNEYNDA 630
CS C N Y C C G E+ D K+ + E FL+ + + I ++S + ++
Sbjct: 302 CSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKIS--TDGSNY 359
Query: 631 VIPIKDLKEVSALALYVSGSKLYWSDSKTKT---INRCSVNGSAVEKIVEWLGLVEGLAI 687
+ + L V A+ +YW DS INR +NGS + K+V + LA+
Sbjct: 360 TLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDI-KVVHNTAVPNALAV 418
Query: 688 DWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGS-KS 746
DW G+N+YW+DT + IEVS+L+G ++ + LK P+ + LDP+ GY+YW +
Sbjct: 419 DWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPH 478
Query: 747 IKRAAMDGSSVSVFME-QVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLAD- 804
I R MDG++ SV +E ++ R AL IDY R +YWA D +EF+ ++G+ R + +
Sbjct: 479 IGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWA--DENHIEFSNMDGSHRHKVPNQ 536
Query: 805 NIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYH--RAKSM 862
+IP AL LF D +YW D T + +A KT G++R S+ I+D+++YH R +
Sbjct: 537 DIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDV 596
Query: 863 GSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
+ C ++NGGCSHLCL PG T CACP ++ L DN TC
Sbjct: 597 SKHLCMINNGGCSHLCLLAPGKTHT---CACPTNFYLAADNRTC 637
Score = 182 bits (443), Expect = 7e-45
Identities = 103/346 (29%), Positives = 177/346 (51%), Gaps = 17/346 (4%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLRENSSTTC--YDSPQMLLVVAQRSTISKISLDSPDF 324
CS C+ + Y C C G +++ ++ C + L++A I KIS D +
Sbjct: 302 CSQQCINTYGT--YKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSN- 358
Query: 325 TPYTLPLKDLKRTLTVDFDPKTEYIYWADGL---AKTISKARLDGSDQSVVVRSSGVPDS 381
YTL + L + +DFD + E+IYW D I++ L+GSD VV ++ VP++
Sbjct: 359 --YTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVV-HNTAVPNA 415
Query: 382 IAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNE 441
+A+D + + +YW+D I V++L+G Y +++ L PR ++L AG+++W D E
Sbjct: 416 LAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCE 475
Query: 442 KKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKE 501
P I R +DG+ + ++I K++ P ++ +D VN +LYW D + IE NMDG+ R +
Sbjct: 476 -YPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWAD--ENHIEFSNMDGSHRHK 532
Query: 502 LHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFR--L 559
+ + DI + + ++L R +K +G DR ++ + ++ +
Sbjct: 533 VPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYR 592
Query: 560 GAPLGWNPCADDNGGCSHLCFNRP-DDYICGCPLGLELTADKKTCV 604
+ + C +NGGCSHLC P + C CP L AD +TC+
Sbjct: 593 QPDVSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTCL 638
Score = 151 bits (367), Expect = 1e-35
Identities = 89/286 (31%), Positives = 134/286 (46%), Gaps = 9/286 (3%)
Query: 11 TTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIA 70
T + + L A+DF YR+ I W D +N G K+V V P +A
Sbjct: 360 TLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRIN-RMCLNGSDIKVVHNTAV-PNALA 417
Query: 71 IDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIP 130
+DW LYW+D E IEV + Y +L + R +++ P+ G ++W D E P
Sbjct: 418 VDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYP 477
Query: 131 KIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRV 190
I R GM+G + V++ I P +T+DY N +YW D ++ + +G R +V
Sbjct: 478 HIGRVGMDG--TNQSVVIETKISRPMALTIDYVNRRLYWADE--NHIEFSNMDGSHRHKV 533
Query: 191 VKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESR 250
+ ALT D +YWTD + S+ + ++ + H + DI+VY R
Sbjct: 534 PNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAI-TDIQVYHSYR 592
Query: 251 QIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSST 296
Q + C NN GCSHLCLL+P + CACPT L ++ T
Sbjct: 593 Q-PDVSKHLCMINNGGCSHLCLLAPGKT-HTCACPTNFYLAADNRT 636
Score = 89.4 bits (212), Expect = 7e-17
Identities = 86/362 (23%), Positives = 151/362 (41%), Gaps = 43/362 (11%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTCV----EPEAFLVYSRKNIIGRLSIKNEYN 628
G CSH C N Y C C + TC+ E + + + +I+G + N
Sbjct: 1176 GTCSHQCINVEGSYKCVCDQNFQ--ERNNTCIAEGSEDQVLYIANDTDILGFIYPFNYSG 1233
Query: 629 D--AVIPIKDLKEVSALALYVSGSKLYWSDS-KTKTINRCSVNGSAVEKIVEWLGLVE-- 683
D + I+ ++ + +Y + WS I ++G + L E
Sbjct: 1234 DHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFK 1293
Query: 684 ---GLAIDWSGQNIYWTDTTTQR---------------IEVSRLDGSSRRAIIWQGLKKP 725
+A+DW NIYWTD + I V +L+G + ++ +P
Sbjct: 1294 RPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEP 1353
Query: 726 KSIVLDPKKGYMYWSELGSKS-IKRAAMDGSSVSVFMEQ-VGRVHALAIDYERRAIYWAA 783
+I ++PK+G MYW+ +G S I+ AAMDG+ + +++ + R LA+DY IYWA
Sbjct: 1354 YAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWAD 1413
Query: 784 LDPPVVEFAFLNGTGRQTLADN---IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNR 840
+ ++ +G+ + + P+ + +F D +Y G + + +K +
Sbjct: 1414 FELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKNG-VFRVQKFGHGSV 1472
Query: 841 KSIRKDLDYISDLKLYHRAKSMG-SNQCGVDNGGCSHLCLPTPGDVRTDYRCACP-AHYR 898
+ + ++D + + HR K + N C +D C LCL P C CP Y
Sbjct: 1473 EYLALNIDKTKGVLISHRYKQLDLPNPC-LDL-ACEFLCLLNPSGA----TCVCPEGKYL 1526
Query: 899 LN 900
+N
Sbjct: 1527 IN 1528
Score = 89.4 bits (212), Expect = 7e-17
Identities = 79/290 (27%), Positives = 127/290 (43%), Gaps = 37/290 (12%)
Query: 21 TAVDFHYRKNLICWSDQ-KPELIQCMNYNETYTGEKFKIVSEGLVTPT-----GIAIDWY 74
T +D +Y++++I WS Q P I Y + EK + + GL+ P IA+DW
Sbjct: 1248 TGMDVYYQRDMIIWSTQFNPGGIF---YKRIHGREK-RQANSGLICPEFKRPRDIAVDWV 1303
Query: 75 TDKLYWTDGETN---------------KIEVISIVQKYRKVLFWSEVDLARAIAVVPEDG 119
+YWTD I V + L + AIAV P+ G
Sbjct: 1304 AGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRG 1363
Query: 120 LMFWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDV 179
+M+WT G+ IE A M+G R+++V+ N+ P G+ VDY + IYW D +L +
Sbjct: 1364 MMYWTVVGDHSHIEEAAMDG--TLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGS 1421
Query: 180 IDFNGEKRKRVV--KGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSH 237
+ ++G V K GL++P + D +Y +N ++ +G ++ L +
Sbjct: 1422 VLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKN-GVFRVQKFGHG-SVEYLALNI 1479
Query: 238 PVPADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTG 287
+ + +Q+ D P + C LCLL+P G C CP G
Sbjct: 1480 DKTKGVLISHRYKQL----DLPNPCLDLACEFLCLLNPS--GATCVCPEG 1523
Score = 66.5 bits (155), Expect = 5e-10
Identities = 57/226 (25%), Positives = 96/226 (42%), Gaps = 19/226 (8%)
Query: 874 CSHLCLPTPGDVRTDYRCACPAHYRLNKDNIT-C---SEPEEFLLFAQKNAVGRIMVANG 929
CS C+ T G Y+C C Y + DN C S+ E FL+ A + + +I
Sbjct: 302 CSQQCINTYGT----YKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKIST--- 354
Query: 930 ECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGL 989
+ ++ + GL NV AI++D E+ +YW+D + R+
Sbjct: 355 DGSNYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRI----NRMCLNGSDIKVVHNT 410
Query: 990 SRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLI 1049
+ P + +D +G+ +YW+ ++ I + ++ T ++V PR L+ YL
Sbjct: 411 AVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPT-ILVSKRLKFPRDLSLDPQAGYLY 469
Query: 1050 WNDVGR-GAIMRANVDGTGR--VELARADNATALALDQSAGTVYWA 1092
W D I R +DGT + V + AL +D +YWA
Sbjct: 470 WIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWA 515
Score = 58.8 bits (136), Expect = 1e-07
Identities = 72/304 (23%), Positives = 129/304 (42%), Gaps = 21/304 (6%)
Query: 566 NPCADDN-GGCSHLCFNRPDDYICGCPLGLELTADKKTCV---EPEAFLVYSRKNIIGRL 621
N C GCS C + P Y C C G +L D KTCV E + S++ I
Sbjct: 252 NECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYG 311
Query: 622 SIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGL 681
+ K D I+ +L L +D I + S +GS + + L
Sbjct: 312 TYKCLCTDG-YEIQPDNPNGCKSLSDEEPFLILADH--HEIRKISTDGSNYTLLKQGLNN 368
Query: 682 VEGLAIDWSGQNIYWTDTTT---QRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMY 738
V + D+ + IYW D++ RI L+GS + + P ++ +D +Y
Sbjct: 369 VIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVV--HNTAVPNALAVDWIGKNLY 426
Query: 739 WSELGSKSIKRAAMDGSSVSVFM-EQVGRVHALAIDYERRAIYWA-ALDPPVVEFAFLNG 796
WS+ + I+ + ++G ++ + +++ L++D + +YW + P + ++G
Sbjct: 427 WSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDG 486
Query: 797 TGRQTLAD-NIPMPYALAL--FNDSVYWGDWNTGQIQQARKTDGSNRKSI-RKDLDYISD 852
T + + + I P AL + N +YW D N + DGS+R + +D+ +
Sbjct: 487 TNQSVVIETKISRPMALTIDYVNRRLYWADENHIEFS---NMDGSHRHKVPNQDIPGVIA 543
Query: 853 LKLY 856
L L+
Sbjct: 544 LTLF 547
Score = 55.6 bits (128), Expect = 1e-06
Identities = 77/352 (21%), Positives = 129/352 (36%), Gaps = 31/352 (8%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKI-SLDSPDFT 325
CSH C+ Y C C + R N+ Q+L + + I +
Sbjct: 1178 CSHQCINVEG--SYKCVCDQNFQERNNTCIAEGSEDQVLYIANDTDILGFIYPFNYSGDH 1235
Query: 326 PYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKT-ISKARLDGSDQ-----SVVVRSSGVP 379
++ R +D + + I W+ I R+ G ++ ++ P
Sbjct: 1236 QQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFKRP 1295
Query: 380 DSIAIDPLSRKIYWTD---------------PVMDTINVARLDGSYEKVIIHTELYDPRA 424
IA+D ++ IYWTD + +INV +L+G ++ +P A
Sbjct: 1296 RDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYA 1355
Query: 425 IALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDA 484
IA++ G M+W+ + IE A +DG+ R +L+ + L P +A+D + ++YW D
Sbjct: 1356 IAVNPKRGMMYWTVVGDHS-HIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADF 1414
Query: 485 RTHKIEVCNMDGTERKELHSN--DIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQ 542
I DG+ S+ ++H K + R+ K +
Sbjct: 1415 ELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAG-PKNGVFRVQKFGHGSVE 1473
Query: 543 PVVEQMANMMGVKAFRLGAPLGW-NPCADDNGGCSHLCFNRPDDYICGCPLG 593
+ + GV L NPC D C LC P C CP G
Sbjct: 1474 YLALNIDKTKGVLISHRYKQLDLPNPCLD--LACEFLCLLNPSGATCVCPEG 1523
Score = 52.8 bits (121), Expect = 7e-06
Identities = 44/187 (23%), Positives = 90/187 (48%), Gaps = 14/187 (7%)
Query: 35 SDQKPELIQCMNYNE---TYTGEKFKIVSEGLVTPTGIAIDWYTDKLYWTDGET---NKI 88
SD++P LI ++ + G + ++ +GL I D+ + +YW D ++I
Sbjct: 335 SDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRI 394
Query: 89 EVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERAGMNGDPATRKVIV 148
+ + KV+ + V A A+ + ++ ++W+D E IE + +NG T ++V
Sbjct: 395 NRMCLNGSDIKVVHNTAVPNALAVDWIGKN--LYWSD-TEKRIIEVSKLNGLYPT--ILV 449
Query: 149 RDNIFWPNGITVDYNNSLIYWVD-AKLQFVDVIDFNGEKRKRVVKGGLVYPFALT--FSN 205
+ +P +++D +YW+D + + + +G + V++ + P ALT + N
Sbjct: 450 SKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVN 509
Query: 206 DKLYWTD 212
+LYW D
Sbjct: 510 RRLYWAD 516
Score = 50.4 bits (115), Expect = 4e-05
Identities = 29/85 (34%), Positives = 37/85 (43%), Gaps = 23/85 (27%)
Query: 1097 CDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCI 1156
CDG++DC DG DE C + C + +AF C +CI
Sbjct: 105 CDGERDCPDGSDELSTAGCAPNNTCDE----------------------NAFMCHNKVCI 142
Query: 1157 AARFVCDGRPQCADGSDEAPAACAY 1181
+FVCD C DGSDE+P C Y
Sbjct: 143 PKQFVCDHDDDCGDGSDESP-QCGY 166
Score = 50.0 bits (114), Expect = 5e-05
Identities = 36/114 (31%), Positives = 44/114 (38%), Gaps = 28/114 (24%)
Query: 1097 CDGQQDCEDGRDEAECGA--------------------CGGDVRCADGTXXXXXXXXXXX 1136
CDGQ+DCEDGRDE C + C G+ C DG
Sbjct: 25 CDGQKDCEDGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAIT 84
Query: 1137 XXXXXXXXXDAFRCDEG-LCIAARFVCDGRPQCADGSDE-APAACAYGHTDQVN 1188
D F C C+ ++CDG C DGSDE + A CA +T N
Sbjct: 85 CAA------DMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDEN 132
Score = 47.6 bits (108), Expect = 3e-04
Identities = 31/103 (30%), Positives = 38/103 (36%), Gaps = 15/103 (14%)
Query: 1092 AVSRQCDGQQDCEDGRDEAECGA--------CGGDVRC------ADGTXXXXXXXXXXXX 1137
+ S +C+G+ DC DG DE +C C C DG
Sbjct: 932 SASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENC 991
Query: 1138 XXXXXX-XXDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
D F C+ LC +VCDG C D SDEAP C
Sbjct: 992 ERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMC 1034
Score = 46.8 bits (106), Expect = 5e-04
Identities = 29/91 (31%), Positives = 33/91 (36%), Gaps = 12/91 (13%)
Query: 1096 QCDGQQDCEDGRDEAECG--ACG-GDVRCADGTXXXXX---------XXXXXXXXXXXXX 1143
+CD Q DC D DE C C D CA+G
Sbjct: 818 RCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNCETSC 877
Query: 1144 XXDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
D FRC G CI A++ CDG C G DE
Sbjct: 878 SKDQFRCSNGQCIPAKWKCDGHEDCKYGEDE 908
Score = 40.3 bits (90), Expect = 0.041
Identities = 36/154 (23%), Positives = 59/154 (38%), Gaps = 11/154 (7%)
Query: 939 TGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLD 998
T + N A+++ + K LYW D + +R+ I L P + LD
Sbjct: 410 TAVPNALAVDW--IGKNLYWSDTE----KRI-IEVSKLNGLYPTILVSKRLKFPRDLSLD 462
Query: 999 VLGRTMYWT-CADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGA 1057
+YW C + I +D + + V++ P L R L W D
Sbjct: 463 PQAGYLYWIDCCEYPHIGRVGMDGTNQS-VVIETKISRPMALTIDYVNRRLYWADENH-- 519
Query: 1058 IMRANVDGTGRVELARADNATALALDQSAGTVYW 1091
I +N+DG+ R ++ D +AL +YW
Sbjct: 520 IEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYW 553
Score = 39.9 bits (89), Expect = 0.054
Identities = 26/82 (31%), Positives = 32/82 (39%), Gaps = 4/82 (4%)
Query: 1095 RQCDGQQ-DCEDGRDEAECG-ACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDE 1152
RQC ++ C DGR C GD C D + F C
Sbjct: 167 RQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAXQSCNSSF--FMCKN 224
Query: 1153 GLCIAARFVCDGRPQCADGSDE 1174
G CI + +CD + C DGSDE
Sbjct: 225 GRCIPSGGLCDNKDDCGDGSDE 246
Score = 39.1 bits (87), Expect = 0.094
Identities = 14/27 (51%), Positives = 16/27 (59%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDE 1174
F+C GLC F+CDG C D SDE
Sbjct: 686 FQCGTGLCALPAFICDGENDCGDNSDE 712
Score = 36.7 bits (81), Expect = 0.50
Identities = 13/27 (48%), Positives = 16/27 (59%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDE 1174
F C G CI ++CDG+ C DG DE
Sbjct: 11 FSCPSGRCILNTWICDGQKDCEDGRDE 37
Score = 35.9 bits (79), Expect = 0.87
Identities = 28/94 (29%), Positives = 33/94 (35%), Gaps = 15/94 (15%)
Query: 1097 CDGQQDCEDGRDEAECGA--C-GGDVRCADGTXXXXXXXXXXXXXX-----------XXX 1142
CDG+ DC D DE C C G +C
Sbjct: 700 CDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENS 759
Query: 1143 XXXDAFRCDEGL-CIAARFVCDGRPQCADGSDEA 1175
D F+C CI+ +VCD P CAD SDEA
Sbjct: 760 CSPDYFQCKTTKHCISKLWVCDEDPDCADASDEA 793
Score = 34.7 bits (76), Expect = 2.0
Identities = 25/96 (26%), Positives = 36/96 (37%), Gaps = 14/96 (14%)
Query: 1093 VSRQCDGQQDCEDGRDEAEC--GACGGD-VRCADGTXXXXXXXXXXXXXXXXXXXXDA-- 1147
V+ +C+GQ DC D DE +C +C D +C +A
Sbjct: 736 VNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANC 795
Query: 1148 ---------FRCDEGLCIAARFVCDGRPQCADGSDE 1174
F+C CI + CD + C+D SDE
Sbjct: 796 DKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDE 831
Score = 32.7 bits (71), Expect = 8.1
Identities = 14/32 (43%), Positives = 19/32 (59%), Gaps = 1/32 (3%)
Query: 1146 DAFRCDEGLCIA-ARFVCDGRPQCADGSDEAP 1176
+ F C +G C+ ++ CDG C D SDEAP
Sbjct: 172 EEFSCADGRCLLNTQWQCDGDFDCPDHSDEAP 203
>AB209707-1|BAD92944.1| 1720|Homo sapiens low density
lipoprotein-related protein 1B variant protein.
Length = 1720
Score = 211 bits (516), Expect = 1e-53
Identities = 124/344 (36%), Positives = 188/344 (54%), Gaps = 20/344 (5%)
Query: 575 CSHLCFNRPDDYICGCPLGLELTADK----KTCVEPEAFLVYSRKNIIGRLSIKNEYNDA 630
CS C N Y C C G E+ D K+ + E FL+ + + I ++S + ++
Sbjct: 99 CSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKIS--TDGSNY 156
Query: 631 VIPIKDLKEVSALALYVSGSKLYWSDSKTKT---INRCSVNGSAVEKIVEWLGLVEGLAI 687
+ + L V A+ +YW DS INR +NGS + K+V + LA+
Sbjct: 157 TLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDI-KVVHNTAVPNALAV 215
Query: 688 DWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGS-KS 746
DW G+N+YW+DT + IEVS+L+G ++ + LK P+ + LDP+ GY+YW +
Sbjct: 216 DWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPH 275
Query: 747 IKRAAMDGSSVSVFME-QVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLAD- 804
I R MDG++ SV +E ++ R AL IDY R +YWA D +EF+ ++G+ R + +
Sbjct: 276 IGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWA--DENHIEFSNMDGSHRHKVPNQ 333
Query: 805 NIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYH--RAKSM 862
+IP AL LF D +YW D T + +A KT G++R S+ I+D+++YH R +
Sbjct: 334 DIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDV 393
Query: 863 GSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
+ C ++NGGCSHLCL PG T CACP ++ L DN TC
Sbjct: 394 SKHLCMINNGGCSHLCLLAPGKTHT---CACPTNFYLAADNRTC 434
Score = 182 bits (443), Expect = 7e-45
Identities = 103/346 (29%), Positives = 177/346 (51%), Gaps = 17/346 (4%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLRENSSTTC--YDSPQMLLVVAQRSTISKISLDSPDF 324
CS C+ + Y C C G +++ ++ C + L++A I KIS D +
Sbjct: 99 CSQQCINTYGT--YKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSN- 155
Query: 325 TPYTLPLKDLKRTLTVDFDPKTEYIYWADGL---AKTISKARLDGSDQSVVVRSSGVPDS 381
YTL + L + +DFD + E+IYW D I++ L+GSD VV ++ VP++
Sbjct: 156 --YTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVV-HNTAVPNA 212
Query: 382 IAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNE 441
+A+D + + +YW+D I V++L+G Y +++ L PR ++L AG+++W D E
Sbjct: 213 LAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCE 272
Query: 442 KKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKE 501
P I R +DG+ + ++I K++ P ++ +D VN +LYW D + IE NMDG+ R +
Sbjct: 273 -YPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWAD--ENHIEFSNMDGSHRHK 329
Query: 502 LHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFR--L 559
+ + DI + + ++L R +K +G DR ++ + ++ +
Sbjct: 330 VPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYR 389
Query: 560 GAPLGWNPCADDNGGCSHLCFNRP-DDYICGCPLGLELTADKKTCV 604
+ + C +NGGCSHLC P + C CP L AD +TC+
Sbjct: 390 QPDVSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTCL 435
Score = 151 bits (367), Expect = 1e-35
Identities = 89/286 (31%), Positives = 134/286 (46%), Gaps = 9/286 (3%)
Query: 11 TTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIA 70
T + + L A+DF YR+ I W D +N G K+V V P +A
Sbjct: 157 TLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRIN-RMCLNGSDIKVVHNTAV-PNALA 214
Query: 71 IDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIP 130
+DW LYW+D E IEV + Y +L + R +++ P+ G ++W D E P
Sbjct: 215 VDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYP 274
Query: 131 KIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRV 190
I R GM+G + V++ I P +T+DY N +YW D ++ + +G R +V
Sbjct: 275 HIGRVGMDG--TNQSVVIETKISRPMALTIDYVNRRLYWADE--NHIEFSNMDGSHRHKV 330
Query: 191 VKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESR 250
+ ALT D +YWTD + S+ + ++ + H + DI+VY R
Sbjct: 331 PNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAI-TDIQVYHSYR 389
Query: 251 QIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSST 296
Q + C NN GCSHLCLL+P + CACPT L ++ T
Sbjct: 390 Q-PDVSKHLCMINNGGCSHLCLLAPGKT-HTCACPTNFYLAADNRT 433
Score = 89.4 bits (212), Expect = 7e-17
Identities = 86/362 (23%), Positives = 151/362 (41%), Gaps = 43/362 (11%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTCV----EPEAFLVYSRKNIIGRLSIKNEYN 628
G CSH C N Y C C + TC+ E + + + +I+G + N
Sbjct: 973 GTCSHQCINVEGSYKCVCDQNFQ--ERNNTCIAEGSEDQVLYIANDTDILGFIYPFNYSG 1030
Query: 629 D--AVIPIKDLKEVSALALYVSGSKLYWSDS-KTKTINRCSVNGSAVEKIVEWLGLVE-- 683
D + I+ ++ + +Y + WS I ++G + L E
Sbjct: 1031 DHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFK 1090
Query: 684 ---GLAIDWSGQNIYWTDTTTQR---------------IEVSRLDGSSRRAIIWQGLKKP 725
+A+DW NIYWTD + I V +L+G + ++ +P
Sbjct: 1091 RPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEP 1150
Query: 726 KSIVLDPKKGYMYWSELGSKS-IKRAAMDGSSVSVFMEQ-VGRVHALAIDYERRAIYWAA 783
+I ++PK+G MYW+ +G S I+ AAMDG+ + +++ + R LA+DY IYWA
Sbjct: 1151 YAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWAD 1210
Query: 784 LDPPVVEFAFLNGTGRQTLADN---IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNR 840
+ ++ +G+ + + P+ + +F D +Y G + + +K +
Sbjct: 1211 FELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKNG-VFRVQKFGHGSV 1269
Query: 841 KSIRKDLDYISDLKLYHRAKSMG-SNQCGVDNGGCSHLCLPTPGDVRTDYRCACP-AHYR 898
+ + ++D + + HR K + N C +D C LCL P C CP Y
Sbjct: 1270 EYLALNIDKTKGVLISHRYKQLDLPNPC-LDL-ACEFLCLLNPSGA----TCVCPEGKYL 1323
Query: 899 LN 900
+N
Sbjct: 1324 IN 1325
Score = 89.4 bits (212), Expect = 7e-17
Identities = 79/290 (27%), Positives = 127/290 (43%), Gaps = 37/290 (12%)
Query: 21 TAVDFHYRKNLICWSDQ-KPELIQCMNYNETYTGEKFKIVSEGLVTPT-----GIAIDWY 74
T +D +Y++++I WS Q P I Y + EK + + GL+ P IA+DW
Sbjct: 1045 TGMDVYYQRDMIIWSTQFNPGGIF---YKRIHGREK-RQANSGLICPEFKRPRDIAVDWV 1100
Query: 75 TDKLYWTDGETN---------------KIEVISIVQKYRKVLFWSEVDLARAIAVVPEDG 119
+YWTD I V + L + AIAV P+ G
Sbjct: 1101 AGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRG 1160
Query: 120 LMFWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDV 179
+M+WT G+ IE A M+G R+++V+ N+ P G+ VDY + IYW D +L +
Sbjct: 1161 MMYWTVVGDHSHIEEAAMDG--TLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGS 1218
Query: 180 IDFNGEKRKRVV--KGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSH 237
+ ++G V K GL++P + D +Y +N ++ +G ++ L +
Sbjct: 1219 VLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKN-GVFRVQKFGHG-SVEYLALNI 1276
Query: 238 PVPADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTG 287
+ + +Q+ D P + C LCLL+P G C CP G
Sbjct: 1277 DKTKGVLISHRYKQL----DLPNPCLDLACEFLCLLNPS--GATCVCPEG 1320
Score = 66.5 bits (155), Expect = 5e-10
Identities = 57/226 (25%), Positives = 96/226 (42%), Gaps = 19/226 (8%)
Query: 874 CSHLCLPTPGDVRTDYRCACPAHYRLNKDNIT-C---SEPEEFLLFAQKNAVGRIMVANG 929
CS C+ T G Y+C C Y + DN C S+ E FL+ A + + +I
Sbjct: 99 CSQQCINTYGT----YKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKIST--- 151
Query: 930 ECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGL 989
+ ++ + GL NV AI++D E+ +YW+D + R+
Sbjct: 152 DGSNYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRI----NRMCLNGSDIKVVHNT 207
Query: 990 SRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLI 1049
+ P + +D +G+ +YW+ ++ I + ++ T ++V PR L+ YL
Sbjct: 208 AVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPT-ILVSKRLKFPRDLSLDPQAGYLY 266
Query: 1050 WNDVGR-GAIMRANVDGTGR--VELARADNATALALDQSAGTVYWA 1092
W D I R +DGT + V + AL +D +YWA
Sbjct: 267 WIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWA 312
Score = 58.8 bits (136), Expect = 1e-07
Identities = 72/304 (23%), Positives = 129/304 (42%), Gaps = 21/304 (6%)
Query: 566 NPCADDN-GGCSHLCFNRPDDYICGCPLGLELTADKKTCV---EPEAFLVYSRKNIIGRL 621
N C GCS C + P Y C C G +L D KTCV E + S++ I
Sbjct: 49 NECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYG 108
Query: 622 SIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGL 681
+ K D I+ +L L +D I + S +GS + + L
Sbjct: 109 TYKCLCTDG-YEIQPDNPNGCKSLSDEEPFLILADH--HEIRKISTDGSNYTLLKQGLNN 165
Query: 682 VEGLAIDWSGQNIYWTDTTT---QRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMY 738
V + D+ + IYW D++ RI L+GS + + P ++ +D +Y
Sbjct: 166 VIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVV--HNTAVPNALAVDWIGKNLY 223
Query: 739 WSELGSKSIKRAAMDGSSVSVFM-EQVGRVHALAIDYERRAIYWA-ALDPPVVEFAFLNG 796
WS+ + I+ + ++G ++ + +++ L++D + +YW + P + ++G
Sbjct: 224 WSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDG 283
Query: 797 TGRQTLAD-NIPMPYALAL--FNDSVYWGDWNTGQIQQARKTDGSNRKSI-RKDLDYISD 852
T + + + I P AL + N +YW D N + DGS+R + +D+ +
Sbjct: 284 TNQSVVIETKISRPMALTIDYVNRRLYWADENHIEFS---NMDGSHRHKVPNQDIPGVIA 340
Query: 853 LKLY 856
L L+
Sbjct: 341 LTLF 344
Score = 55.6 bits (128), Expect = 1e-06
Identities = 77/352 (21%), Positives = 129/352 (36%), Gaps = 31/352 (8%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKI-SLDSPDFT 325
CSH C+ Y C C + R N+ Q+L + + I +
Sbjct: 975 CSHQCINVEG--SYKCVCDQNFQERNNTCIAEGSEDQVLYIANDTDILGFIYPFNYSGDH 1032
Query: 326 PYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKT-ISKARLDGSDQ-----SVVVRSSGVP 379
++ R +D + + I W+ I R+ G ++ ++ P
Sbjct: 1033 QQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFKRP 1092
Query: 380 DSIAIDPLSRKIYWTD---------------PVMDTINVARLDGSYEKVIIHTELYDPRA 424
IA+D ++ IYWTD + +INV +L+G ++ +P A
Sbjct: 1093 RDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYA 1152
Query: 425 IALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDA 484
IA++ G M+W+ + IE A +DG+ R +L+ + L P +A+D + ++YW D
Sbjct: 1153 IAVNPKRGMMYWTVVGDHS-HIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADF 1211
Query: 485 RTHKIEVCNMDGTERKELHSN--DIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQ 542
I DG+ S+ ++H K + R+ K +
Sbjct: 1212 ELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAG-PKNGVFRVQKFGHGSVE 1270
Query: 543 PVVEQMANMMGVKAFRLGAPLGW-NPCADDNGGCSHLCFNRPDDYICGCPLG 593
+ + GV L NPC D C LC P C CP G
Sbjct: 1271 YLALNIDKTKGVLISHRYKQLDLPNPCLD--LACEFLCLLNPSGATCVCPEG 1320
Score = 52.8 bits (121), Expect = 7e-06
Identities = 44/187 (23%), Positives = 90/187 (48%), Gaps = 14/187 (7%)
Query: 35 SDQKPELIQCMNYNE---TYTGEKFKIVSEGLVTPTGIAIDWYTDKLYWTDGET---NKI 88
SD++P LI ++ + G + ++ +GL I D+ + +YW D ++I
Sbjct: 132 SDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRI 191
Query: 89 EVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERAGMNGDPATRKVIV 148
+ + KV+ + V A A+ + ++ ++W+D E IE + +NG T ++V
Sbjct: 192 NRMCLNGSDIKVVHNTAVPNALAVDWIGKN--LYWSD-TEKRIIEVSKLNGLYPT--ILV 246
Query: 149 RDNIFWPNGITVDYNNSLIYWVD-AKLQFVDVIDFNGEKRKRVVKGGLVYPFALT--FSN 205
+ +P +++D +YW+D + + + +G + V++ + P ALT + N
Sbjct: 247 SKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVN 306
Query: 206 DKLYWTD 212
+LYW D
Sbjct: 307 RRLYWAD 313
Score = 47.6 bits (108), Expect = 3e-04
Identities = 31/103 (30%), Positives = 38/103 (36%), Gaps = 15/103 (14%)
Query: 1092 AVSRQCDGQQDCEDGRDEAECGA--------CGGDVRC------ADGTXXXXXXXXXXXX 1137
+ S +C+G+ DC DG DE +C C C DG
Sbjct: 729 SASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENC 788
Query: 1138 XXXXXX-XXDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
D F C+ LC +VCDG C D SDEAP C
Sbjct: 789 ERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMC 831
Score = 46.8 bits (106), Expect = 5e-04
Identities = 29/91 (31%), Positives = 33/91 (36%), Gaps = 12/91 (13%)
Query: 1096 QCDGQQDCEDGRDEAECG--ACG-GDVRCADGTXXXXX---------XXXXXXXXXXXXX 1143
+CD Q DC D DE C C D CA+G
Sbjct: 615 RCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNCETSC 674
Query: 1144 XXDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
D FRC G CI A++ CDG C G DE
Sbjct: 675 SKDQFRCSNGQCIPAKWKCDGHEDCKYGEDE 705
Score = 40.3 bits (90), Expect = 0.041
Identities = 36/154 (23%), Positives = 59/154 (38%), Gaps = 11/154 (7%)
Query: 939 TGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLD 998
T + N A+++ + K LYW D + +R+ I L P + LD
Sbjct: 207 TAVPNALAVDW--IGKNLYWSDTE----KRI-IEVSKLNGLYPTILVSKRLKFPRDLSLD 259
Query: 999 VLGRTMYWT-CADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGA 1057
+YW C + I +D + + V++ P L R L W D
Sbjct: 260 PQAGYLYWIDCCEYPHIGRVGMDGTNQS-VVIETKISRPMALTIDYVNRRLYWADENH-- 316
Query: 1058 IMRANVDGTGRVELARADNATALALDQSAGTVYW 1091
I +N+DG+ R ++ D +AL +YW
Sbjct: 317 IEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYW 350
Score = 39.1 bits (87), Expect = 0.094
Identities = 14/27 (51%), Positives = 16/27 (59%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDE 1174
F+C GLC F+CDG C D SDE
Sbjct: 483 FQCGTGLCALPAFICDGENDCGDNSDE 509
Score = 35.9 bits (79), Expect = 0.87
Identities = 28/94 (29%), Positives = 33/94 (35%), Gaps = 15/94 (15%)
Query: 1097 CDGQQDCEDGRDEAECGA--C-GGDVRCADGTXXXXXXXXXXXXXX-----------XXX 1142
CDG+ DC D DE C C G +C
Sbjct: 497 CDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENS 556
Query: 1143 XXXDAFRCDEGL-CIAARFVCDGRPQCADGSDEA 1175
D F+C CI+ +VCD P CAD SDEA
Sbjct: 557 CSPDYFQCKTTKHCISKLWVCDEDPDCADASDEA 590
Score = 35.5 bits (78), Expect = 1.2
Identities = 13/27 (48%), Positives = 16/27 (59%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDE 1174
F C G CI + +CD + C DGSDE
Sbjct: 17 FMCKNGRCIPSGGLCDNKDDCGDGSDE 43
Score = 34.7 bits (76), Expect = 2.0
Identities = 25/96 (26%), Positives = 36/96 (37%), Gaps = 14/96 (14%)
Query: 1093 VSRQCDGQQDCEDGRDEAEC--GACGGD-VRCADGTXXXXXXXXXXXXXXXXXXXXDA-- 1147
V+ +C+GQ DC D DE +C +C D +C +A
Sbjct: 533 VNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANC 592
Query: 1148 ---------FRCDEGLCIAARFVCDGRPQCADGSDE 1174
F+C CI + CD + C+D SDE
Sbjct: 593 DKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDE 628
>X04571-1|CAA28240.1| 1207|Homo sapiens protein ( Human mRNA for
kidney epidermal growth factor (EGF) precursor. ).
Length = 1207
Score = 203 bits (495), Expect = 3e-51
Identities = 111/343 (32%), Positives = 167/343 (48%), Gaps = 5/343 (1%)
Query: 263 NNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDSP 322
+N GCS LC+ P + C C G L+ + + PQ L+ A I + D
Sbjct: 443 DNGGCSQLCV-PLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGT 501
Query: 323 DFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSS-GVPDS 381
D+ TL + + +D DP IY+A K I +A +DGS + ++ VP+
Sbjct: 502 DYG--TLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEG 559
Query: 382 IAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNE 441
+A+D + R+ YWTD I + L+G K+I + PR IA+H A +FW+D
Sbjct: 560 LAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGI 619
Query: 442 KKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKE 501
P+IE ++L G GR+++ S L WP+ I +D + +KLYW DA+ IE+ N+DG++R+
Sbjct: 620 N-PRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRR 678
Query: 502 LHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFRLGA 561
L ND+ H F ++ R+NK TG DR + M + A
Sbjct: 679 LTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVRLQGSMLKPSSLVVVHPLA 738
Query: 562 PLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
G +PC NGGC H+C R C C G +D KTC+
Sbjct: 739 KPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCL 781
Score = 157 bits (382), Expect = 2e-37
Identities = 95/343 (27%), Positives = 167/343 (48%), Gaps = 12/343 (3%)
Query: 571 DNGGCSHLCFN-RPDDYICGCPLGLELTADKKTCVE--PEAFLVYSRKNIIGRLSIKNEY 627
DNGGCS LC P + C C G +L D+K+C P+ FL+++ I +
Sbjct: 443 DNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTD 502
Query: 628 NDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVE-WLGLVEGLA 686
++ + + V AL +K+Y++ + K I R +++GS E+++E + + EGLA
Sbjct: 503 YGTLLS-QQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLA 561
Query: 687 IDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELG-SK 745
+DW G+ YWTD I S L+G + I + + +P+ I + P ++W++ G +
Sbjct: 562 VDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINP 621
Query: 746 SIKRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLAD 804
I+ +++ G + + + + ID+ +YW V+E A L+G+ R+ L
Sbjct: 622 RIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQ 681
Query: 805 N-IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHRAKSMG 863
N + P+A+A+F D V++ DW + + K G +R ++ + S L + H G
Sbjct: 682 NDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKPG 741
Query: 864 SNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
++ C NGGC H+C G C+C + D TC
Sbjct: 742 ADPCLYQNGGCEHICKKRLGTA----WCSCREGFMKASDGKTC 780
Score = 128 bits (309), Expect = 1e-28
Identities = 71/253 (28%), Positives = 124/253 (49%), Gaps = 9/253 (3%)
Query: 54 EKFKIVSEGLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIA 113
++ +++ EG+ P G+A+DW + YWTD + I + K K++ + R IA
Sbjct: 545 QRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIA 604
Query: 114 VVPEDGLMFWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAK 173
V P +FWTD G P+IE + + G R VI ++ WP+GIT+D+ +YW DAK
Sbjct: 605 VHPMAKRLFWTDTGINPRIESSSLQG--LGRLVIASSDLIWPSGITIDFLTDKLYWCDAK 662
Query: 174 LQFVDVIDFNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKEL 233
+++ + +G KR+R+ + + +PFA+ D ++++DW S+ + +++ L
Sbjct: 663 QSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVR-L 721
Query: 234 IKSHPVPADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTG-VKLRE 292
S P+ + V + PC N GC H+C C+C G +K +
Sbjct: 722 QGSMLKPSSLVVV---HPLAKPGADPCLYQNGGCEHICKKRLGTAW--CSCREGFMKASD 776
Query: 293 NSSTTCYDSPQML 305
+ D Q+L
Sbjct: 777 GKTCLALDGHQLL 789
Score = 108 bits (260), Expect = 1e-22
Identities = 78/340 (22%), Positives = 148/340 (43%), Gaps = 26/340 (7%)
Query: 590 CPLGLELTADKKTCVEPEAFLVYSRKNIIGRLSIKN-EYNDAVIPIKDLKEVSALALYVS 648
CP G TCV P FL++S N I R+ + Y V+ D + + +
Sbjct: 28 CPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQLVV---DAGVSVIMDFHYN 84
Query: 649 GSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSR 708
++YW D + + + R +NGS E++ V G+AI+W + + W++ I V+
Sbjct: 85 EKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSGMAINWINEEVIWSNQQEGIITVTD 144
Query: 709 LDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKSIKRAAMDGSSVSVFMEQVGRVH 768
+ G++ I+ LK P ++ +DP + +++WS + S+ RA +DG V +E ++
Sbjct: 145 MKGNNSH-ILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALLETSEKIT 203
Query: 769 ALAIDYERRAIYWAALDPP-----VVEFAFLNGTGRQTLADNIPMPYALALFNDSVYWGD 823
A+++D + ++W + + + G+ + +A++LF D +++
Sbjct: 204 AVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYST 263
Query: 824 WNTGQIQQARKTDGSN--RKSIRKDLDYISDLKLYHRAKSMGSNQ---------CGVDNG 872
W I A K G + R ++ + +LK+ H + C + G
Sbjct: 264 WKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKG 323
Query: 873 GCSH-LCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
CS +C G + C C Y L++D C + E
Sbjct: 324 NCSSTVC----GQDLQSHLCMCAEGYALSRDRKYCEDVNE 359
Score = 82.2 bits (194), Expect = 1e-14
Identities = 80/340 (23%), Positives = 147/340 (43%), Gaps = 31/340 (9%)
Query: 283 ACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRTLTVDF 342
+CP G L N ++TC P L+ + ++I +I + T Y + D ++ +DF
Sbjct: 27 SCPEGT-LAGNGNSTCV-GPAPFLIFSHGNSIFRIDTEG---TNYEQLVVDAGVSVIMDF 81
Query: 343 DPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGVPDSIAIDPLSRKIYWTDPVMDTIN 402
+ IYW D + + + L+GS Q V +AI+ ++ ++ W++ I
Sbjct: 82 HYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSGMAINWINEEVIWSNQQEGIIT 141
Query: 403 VARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSG--RVLLI 460
V + G+ +++ Y P +A+ ++FWS +E + RA+LDG G +L
Sbjct: 142 VTDMKGNNSHILLSALKY-PANVAVDPVERFIFWS--SEVAGSLYRADLDGVGVKALLET 198
Query: 461 SEKLTWPNSIALDTVNNKLYW----GDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXX 516
SEK+T +++LD ++ +L+W + I C+ DG ++F
Sbjct: 199 SEKIT---AVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLF 255
Query: 517 XXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFRLGAPLG--------WNP- 567
+ +T+ NK+TG D + ++ + + ++ PL W P
Sbjct: 256 GDRIFYSTWKMKTIWIANKHTGKD-MVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPE 314
Query: 568 ---CADDNGGCSH-LCFNRPDDYICGCPLGLELTADKKTC 603
C G CS +C ++C C G L+ D+K C
Sbjct: 315 QKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYC 354
Score = 81.4 bits (192), Expect = 2e-14
Identities = 65/252 (25%), Positives = 118/252 (46%), Gaps = 13/252 (5%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKL-RENSSTTCYDSPQMLLVVAQRSTISKIS 318
C +N + CSH C+L+ + P C CP G L R+ + + SP +S +S
Sbjct: 401 CPRNVSECSHDCVLTSEGP--LCFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVS 458
Query: 319 LDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVV-RSSG 377
+ F Y L L D K P ++ +A+ ++ I DG+D ++ + G
Sbjct: 459 WECDCFPGYDLQL-DEKSCAASGPQP---FLLFAN--SQDIRHMHFDGTDYGTLLSQQMG 512
Query: 378 VPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWS 437
+ ++ DP+ KIY+ + I A +DGS + +I + P +A+ +W+
Sbjct: 513 MVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWT 572
Query: 438 DWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTH-KIEVCNMDG 496
D K I R++L+G ++ E ++ P IA+ + +L+W D + +IE ++ G
Sbjct: 573 D--RGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQG 630
Query: 497 TERKELHSNDII 508
R + S+D+I
Sbjct: 631 LGRLVIASSDLI 642
Score = 72.1 bits (169), Expect = 1e-11
Identities = 61/271 (22%), Positives = 115/271 (42%), Gaps = 17/271 (6%)
Query: 347 EYIYWADGLAKTISKARLDGSDQSVVVRSSGVPDSIAIDPLSRKIYWTDPVMDTINVARL 406
E + W++ I+ + G++ +++ + P ++A+DP+ R I+W+ V ++ A L
Sbjct: 128 EEVIWSNQQEGIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADL 187
Query: 407 DGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTW 466
DG K ++ T A++L + +FW +N + + D G + IS+ T
Sbjct: 188 DGVGVKALLETS-EKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQ 246
Query: 467 PNSIALDTVNNKLYWGDARTHKIEVCNMD-GTE--RKELHSN-------DIIHIFGXXXX 516
N A+ +++++ + I + N G + R LHS+ ++H
Sbjct: 247 HNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKA 306
Query: 517 XXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFRLGAPLGW----NPCADDN 572
+ L + N ++ + Q + + M + + L + N CA N
Sbjct: 307 EDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLC--MCAEGYALSRDRKYCEDVNECAFWN 364
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
GC+ C N P Y C CP+G L D K C
Sbjct: 365 HGCTLGCKNTPGSYYCTCPVGFVLLPDGKRC 395
Score = 64.5 bits (150), Expect = 2e-09
Identities = 46/201 (22%), Positives = 89/201 (44%), Gaps = 12/201 (5%)
Query: 892 ACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDP 951
+CP N TC P FL+F+ N++ RI G + + G+ + Y+
Sbjct: 27 SCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDT-EGTNYEQLVVDAGVSVIMDFHYN- 84
Query: 952 VEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADR 1011
EK++YW+D + ++RV ++ G M ++ + + W+
Sbjct: 85 -EKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSG------MAINWINEEVIWSNQQE 137
Query: 1012 DSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGAIMRANVDGTG-RVE 1070
I T + N+S I+ P ++A +R++ W+ G++ RA++DG G +
Sbjct: 138 GIITVTDMKGNNSH--ILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKAL 195
Query: 1071 LARADNATALALDQSAGTVYW 1091
L ++ TA++LD ++W
Sbjct: 196 LETSEKITAVSLDVLDKRLFW 216
Score = 57.2 bits (132), Expect = 3e-07
Identities = 40/140 (28%), Positives = 65/140 (46%), Gaps = 6/140 (4%)
Query: 76 DKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERA 135
+K+Y+ IE ++ R+ L VD+ +AV +WTD G+ I R+
Sbjct: 524 NKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGK-SLIGRS 582
Query: 136 GMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQ-FVDVIDFNGEKRKRVVKGG 194
+NG + K+I ++NI P GI V ++W D + ++ G R +
Sbjct: 583 DLNGKRS--KIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSD 640
Query: 195 LVYPFALT--FSNDKLYWTD 212
L++P +T F DKLYW D
Sbjct: 641 LIWPSGITIDFLTDKLYWCD 660
Score = 52.8 bits (121), Expect = 7e-06
Identities = 61/298 (20%), Positives = 124/298 (41%), Gaps = 29/298 (9%)
Query: 8 TRITTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPT 67
T + D +DFHY + I W D + +L+Q + N G + + V +
Sbjct: 64 TNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLN----GSRQERVCNIEKNVS 119
Query: 68 GIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWG 127
G+AI+W +++ W++ + I V + +L S + +AV P + +FW+
Sbjct: 120 GMAINWINEEVIWSNQQEGIITVTDMKGNNSHILL-SALKYPANVAVDPVERFIFWS--S 176
Query: 128 EIP-KIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWV----DAKLQFVDVIDF 182
E+ + RA ++G + + I +++D + ++W+ + + D+
Sbjct: 177 EVAGSLYRADLDGVGVKALLETSEKI---TAVSLDVLDKRLFWIQYNREGSNSLICSCDY 233
Query: 183 NGEK---RKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPV 239
+G K + L FA++ D+++++ W+ +I+ + ++ + S V
Sbjct: 234 DGGSVHISKHPTQHNL---FAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFV 290
Query: 240 P-ADIKVYDESRQIISAED--YP----CKKNNAGCSHLCLLSPDPPGYNCACPTGVKL 290
P ++KV Q + +D P CK CS + D + C C G L
Sbjct: 291 PLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSS-TVCGQDLQSHLCMCAEGYAL 347
Score = 40.7 bits (91), Expect = 0.031
Identities = 63/323 (19%), Positives = 130/323 (40%), Gaps = 29/323 (8%)
Query: 605 EPEAFLVYSRKNIIGRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINR 664
E + V + ++ R+ + + V I+ K VS +A+ ++ WS+ + I
Sbjct: 85 EKRIYWVDLERQLLQRVFLNGSRQERVCNIE--KNVSGMAINWINEEVIWSNQQEGIITV 142
Query: 665 CSVNGSAVEKIVEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKK 724
+ G+ ++ L +A+D + I+W+ + + LDG +A++ + +K
Sbjct: 143 TDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALL-ETSEK 201
Query: 725 PKSIVLDPKKGYMYWSEL---GSKS-IKRAAMDGSSVSVFMEQVGR-VHALAIDYERRAI 779
++ LD ++W + GS S I DG SV + + A+++ +R I
Sbjct: 202 ITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDR--I 259
Query: 780 YWAALDPPVVEFAFLNGTGRQTLADN-----IPM-------PYALALFNDSVYWGDWNTG 827
+++ + A + TG+ + N +P+ P A D + +
Sbjct: 260 FYSTWKMKTIWIANKH-TGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLC 318
Query: 828 QIQQARKTDGSNRKSIRKDLDYISDLKLYHRAKSMGS--NQCGVDNGGCSHLCLPTPGDV 885
++++ + + ++ L ++ R + N+C N GC+ C TPG
Sbjct: 319 KLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPG-- 376
Query: 886 RTDYRCACPAHYRLNKDNITCSE 908
Y C CP + L D C +
Sbjct: 377 --SYYCTCPVGFVLLPDGKRCHQ 397
Score = 36.7 bits (81), Expect = 0.50
Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 6/95 (6%)
Query: 922 GRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXX 981
G I V + + N+++I L+ LK + DPVE+ ++W + + S+ R +
Sbjct: 138 GIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALLE 197
Query: 982 XXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINA 1016
+S LDVL + ++W +R+ N+
Sbjct: 198 TSEKITAVS------LDVLDKRLFWIQYNREGSNS 226
Score = 33.9 bits (74), Expect = 3.5
Identities = 22/89 (24%), Positives = 47/89 (52%), Gaps = 5/89 (5%)
Query: 167 IYWVDAKLQFVDVIDFNGEKRKRVVKGGLVYP--FALTFSNDKLYWTDWQNWSIYTWDIA 224
IY+ L++++ + +G +R+R+++ G+ P A+ + + YWTD I D+
Sbjct: 526 IYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDL- 584
Query: 225 ANGPKIKELIKSH-PVPADIKVYDESRQI 252
NG + K + K + P I V+ ++++
Sbjct: 585 -NGKRSKIITKENISQPRGIAVHPMAKRL 612
Score = 33.1 bits (72), Expect = 6.2
Identities = 28/137 (20%), Positives = 52/137 (37%), Gaps = 7/137 (5%)
Query: 940 GLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDV 999
G+ + D + ++ YW D I R ++ +S+P + +
Sbjct: 553 GVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLN-----GKRSKIITKENISQPRGIAVHP 607
Query: 1000 LGRTMYWTCAD-RDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGAI 1058
+ + ++WT I ++S+ VI D + P + L W D + I
Sbjct: 608 MAKRLFWTDTGINPRIESSSLQGLGRL-VIASSDLIWPSGITIDFLTDKLYWCDAKQSVI 666
Query: 1059 MRANVDGTGRVELARAD 1075
AN+DG+ R L + D
Sbjct: 667 EMANLDGSKRRRLTQND 683
>BC113461-1|AAI13462.1| 1207|Homo sapiens epidermal growth factor
(beta-urogastrone) protein.
Length = 1207
Score = 203 bits (495), Expect = 3e-51
Identities = 111/343 (32%), Positives = 167/343 (48%), Gaps = 5/343 (1%)
Query: 263 NNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDSP 322
+N GCS LC+ P + C C G L+ + + PQ L+ A I + D
Sbjct: 443 DNGGCSQLCV-PLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGT 501
Query: 323 DFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSS-GVPDS 381
D+ TL + + +D DP IY+A K I +A +DGS + ++ VP+
Sbjct: 502 DYG--TLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEG 559
Query: 382 IAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNE 441
+A+D + R+ YWTD I + L+G K+I + PR IA+H A +FW+D
Sbjct: 560 LAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGI 619
Query: 442 KKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKE 501
P+IE ++L G GR+++ S L WP+ I +D + +KLYW DA+ IE+ N+DG++R+
Sbjct: 620 N-PRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRR 678
Query: 502 LHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFRLGA 561
L ND+ H F ++ R+NK TG DR + M + A
Sbjct: 679 LTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVRLQGSMLKPSSLVVVHPLA 738
Query: 562 PLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
G +PC NGGC H+C R C C G +D KTC+
Sbjct: 739 KPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCL 781
Score = 157 bits (382), Expect = 2e-37
Identities = 95/343 (27%), Positives = 167/343 (48%), Gaps = 12/343 (3%)
Query: 571 DNGGCSHLCFN-RPDDYICGCPLGLELTADKKTCVE--PEAFLVYSRKNIIGRLSIKNEY 627
DNGGCS LC P + C C G +L D+K+C P+ FL+++ I +
Sbjct: 443 DNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTD 502
Query: 628 NDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVE-WLGLVEGLA 686
++ + + V AL +K+Y++ + K I R +++GS E+++E + + EGLA
Sbjct: 503 YGTLLS-QQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLA 561
Query: 687 IDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELG-SK 745
+DW G+ YWTD I S L+G + I + + +P+ I + P ++W++ G +
Sbjct: 562 VDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINP 621
Query: 746 SIKRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLAD 804
I+ +++ G + + + + ID+ +YW V+E A L+G+ R+ L
Sbjct: 622 RIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQ 681
Query: 805 N-IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHRAKSMG 863
N + P+A+A+F D V++ DW + + K G +R ++ + S L + H G
Sbjct: 682 NDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKPG 741
Query: 864 SNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
++ C NGGC H+C G C+C + D TC
Sbjct: 742 ADPCLYQNGGCEHICKKRLGTA----WCSCREGFMKASDGKTC 780
Score = 128 bits (309), Expect = 1e-28
Identities = 71/253 (28%), Positives = 124/253 (49%), Gaps = 9/253 (3%)
Query: 54 EKFKIVSEGLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIA 113
++ +++ EG+ P G+A+DW + YWTD + I + K K++ + R IA
Sbjct: 545 QRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIA 604
Query: 114 VVPEDGLMFWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAK 173
V P +FWTD G P+IE + + G R VI ++ WP+GIT+D+ +YW DAK
Sbjct: 605 VHPMAKRLFWTDTGINPRIESSSLQG--LGRLVIASSDLIWPSGITIDFLTDKLYWCDAK 662
Query: 174 LQFVDVIDFNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKEL 233
+++ + +G KR+R+ + + +PFA+ D ++++DW S+ + +++ L
Sbjct: 663 QSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVR-L 721
Query: 234 IKSHPVPADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTG-VKLRE 292
S P+ + V + PC N GC H+C C+C G +K +
Sbjct: 722 QGSMLKPSSLVVV---HPLAKPGADPCLYQNGGCEHICKKRLGTAW--CSCREGFMKASD 776
Query: 293 NSSTTCYDSPQML 305
+ D Q+L
Sbjct: 777 GKTCLALDGHQLL 789
Score = 108 bits (260), Expect = 1e-22
Identities = 78/340 (22%), Positives = 148/340 (43%), Gaps = 26/340 (7%)
Query: 590 CPLGLELTADKKTCVEPEAFLVYSRKNIIGRLSIKN-EYNDAVIPIKDLKEVSALALYVS 648
CP G TCV P FL++S N I R+ + Y V+ D + + +
Sbjct: 28 CPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQLVV---DAGVSVIMDFHYN 84
Query: 649 GSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSR 708
++YW D + + + R +NGS E++ V G+AI+W + + W++ I V+
Sbjct: 85 EKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSGMAINWINEEVIWSNQQEGIITVTD 144
Query: 709 LDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKSIKRAAMDGSSVSVFMEQVGRVH 768
+ G++ I+ LK P ++ +DP + +++WS + S+ RA +DG V +E ++
Sbjct: 145 MKGNNSH-ILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALLETSEKIT 203
Query: 769 ALAIDYERRAIYWAALDPP-----VVEFAFLNGTGRQTLADNIPMPYALALFNDSVYWGD 823
A+++D + ++W + + + G+ + +A++LF D +++
Sbjct: 204 AVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYST 263
Query: 824 WNTGQIQQARKTDGSN--RKSIRKDLDYISDLKLYHRAKSMGSNQ---------CGVDNG 872
W I A K G + R ++ + +LK+ H + C + G
Sbjct: 264 WKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKG 323
Query: 873 GCSH-LCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
CS +C G + C C Y L++D C + E
Sbjct: 324 NCSSTVC----GQDLQSHLCMCAEGYALSRDRKYCEDVNE 359
Score = 82.2 bits (194), Expect = 1e-14
Identities = 80/340 (23%), Positives = 147/340 (43%), Gaps = 31/340 (9%)
Query: 283 ACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRTLTVDF 342
+CP G L N ++TC P L+ + ++I +I + T Y + D ++ +DF
Sbjct: 27 SCPEGT-LAGNGNSTCV-GPAPFLIFSHGNSIFRIDTEG---TNYEQLVVDAGVSVIMDF 81
Query: 343 DPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGVPDSIAIDPLSRKIYWTDPVMDTIN 402
+ IYW D + + + L+GS Q V +AI+ ++ ++ W++ I
Sbjct: 82 HYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSGMAINWINEEVIWSNQQEGIIT 141
Query: 403 VARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSG--RVLLI 460
V + G+ +++ Y P +A+ ++FWS +E + RA+LDG G +L
Sbjct: 142 VTDMKGNNSHILLSALKY-PANVAVDPVERFIFWS--SEVAGSLYRADLDGVGVKALLET 198
Query: 461 SEKLTWPNSIALDTVNNKLYW----GDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXX 516
SEK+T +++LD ++ +L+W + I C+ DG ++F
Sbjct: 199 SEKIT---AVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLF 255
Query: 517 XXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFRLGAPLG--------WNP- 567
+ +T+ NK+TG D + ++ + + ++ PL W P
Sbjct: 256 GDRIFYSTWKMKTIWIANKHTGKD-MVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPE 314
Query: 568 ---CADDNGGCSH-LCFNRPDDYICGCPLGLELTADKKTC 603
C G CS +C ++C C G L+ D+K C
Sbjct: 315 QKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYC 354
Score = 81.4 bits (192), Expect = 2e-14
Identities = 65/252 (25%), Positives = 118/252 (46%), Gaps = 13/252 (5%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKL-RENSSTTCYDSPQMLLVVAQRSTISKIS 318
C +N + CSH C+L+ + P C CP G L R+ + + SP +S +S
Sbjct: 401 CPRNVSECSHDCVLTSEGP--LCFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVS 458
Query: 319 LDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVV-RSSG 377
+ F Y L L D K P ++ +A+ ++ I DG+D ++ + G
Sbjct: 459 WECDCFPGYDLQL-DEKSCAASGPQP---FLLFAN--SQDIRHMHFDGTDYGTLLSQQMG 512
Query: 378 VPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWS 437
+ ++ DP+ KIY+ + I A +DGS + +I + P +A+ +W+
Sbjct: 513 MVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWT 572
Query: 438 DWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTH-KIEVCNMDG 496
D K I R++L+G ++ E ++ P IA+ + +L+W D + +IE ++ G
Sbjct: 573 D--RGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQG 630
Query: 497 TERKELHSNDII 508
R + S+D+I
Sbjct: 631 LGRLVIASSDLI 642
Score = 72.1 bits (169), Expect = 1e-11
Identities = 61/271 (22%), Positives = 115/271 (42%), Gaps = 17/271 (6%)
Query: 347 EYIYWADGLAKTISKARLDGSDQSVVVRSSGVPDSIAIDPLSRKIYWTDPVMDTINVARL 406
E + W++ I+ + G++ +++ + P ++A+DP+ R I+W+ V ++ A L
Sbjct: 128 EEVIWSNQQEGIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADL 187
Query: 407 DGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTW 466
DG K ++ T A++L + +FW +N + + D G + IS+ T
Sbjct: 188 DGVGVKALLETS-EKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQ 246
Query: 467 PNSIALDTVNNKLYWGDARTHKIEVCNMD-GTE--RKELHSN-------DIIHIFGXXXX 516
N A+ +++++ + I + N G + R LHS+ ++H
Sbjct: 247 HNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKA 306
Query: 517 XXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFRLGAPLGW----NPCADDN 572
+ L + N ++ + Q + + M + + L + N CA N
Sbjct: 307 EDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLC--MCAEGYALSRDRKYCEDVNECAFWN 364
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
GC+ C N P Y C CP+G L D K C
Sbjct: 365 HGCTLGCKNTPGSYYCTCPVGFVLLPDGKRC 395
Score = 64.5 bits (150), Expect = 2e-09
Identities = 46/201 (22%), Positives = 89/201 (44%), Gaps = 12/201 (5%)
Query: 892 ACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDP 951
+CP N TC P FL+F+ N++ RI G + + G+ + Y+
Sbjct: 27 SCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDT-EGTNYEQLVVDAGVSVIMDFHYN- 84
Query: 952 VEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADR 1011
EK++YW+D + ++RV ++ G M ++ + + W+
Sbjct: 85 -EKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSG------MAINWINEEVIWSNQQE 137
Query: 1012 DSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGAIMRANVDGTG-RVE 1070
I T + N+S I+ P ++A +R++ W+ G++ RA++DG G +
Sbjct: 138 GIITVTDMKGNNSH--ILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKAL 195
Query: 1071 LARADNATALALDQSAGTVYW 1091
L ++ TA++LD ++W
Sbjct: 196 LETSEKITAVSLDVLDKRLFW 216
Score = 57.2 bits (132), Expect = 3e-07
Identities = 40/140 (28%), Positives = 65/140 (46%), Gaps = 6/140 (4%)
Query: 76 DKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERA 135
+K+Y+ IE ++ R+ L VD+ +AV +WTD G+ I R+
Sbjct: 524 NKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGK-SLIGRS 582
Query: 136 GMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQ-FVDVIDFNGEKRKRVVKGG 194
+NG + K+I ++NI P GI V ++W D + ++ G R +
Sbjct: 583 DLNGKRS--KIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSD 640
Query: 195 LVYPFALT--FSNDKLYWTD 212
L++P +T F DKLYW D
Sbjct: 641 LIWPSGITIDFLTDKLYWCD 660
Score = 52.8 bits (121), Expect = 7e-06
Identities = 61/298 (20%), Positives = 124/298 (41%), Gaps = 29/298 (9%)
Query: 8 TRITTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPT 67
T + D +DFHY + I W D + +L+Q + N G + + V +
Sbjct: 64 TNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLN----GSRQERVCNIEKNVS 119
Query: 68 GIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWG 127
G+AI+W +++ W++ + I V + +L S + +AV P + +FW+
Sbjct: 120 GMAINWINEEVIWSNQQEGIITVTDMKGNNSHILL-SALKYPANVAVDPVERFIFWS--S 176
Query: 128 EIP-KIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWV----DAKLQFVDVIDF 182
E+ + RA ++G + + I +++D + ++W+ + + D+
Sbjct: 177 EVAGSLYRADLDGVGVKALLETSEKI---TAVSLDVLDKRLFWIQYNREGSNSLICSCDY 233
Query: 183 NGEK---RKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPV 239
+G K + L FA++ D+++++ W+ +I+ + ++ + S V
Sbjct: 234 DGGSVHISKHPTQHNL---FAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFV 290
Query: 240 P-ADIKVYDESRQIISAED--YP----CKKNNAGCSHLCLLSPDPPGYNCACPTGVKL 290
P ++KV Q + +D P CK CS + D + C C G L
Sbjct: 291 PLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSS-TVCGQDLQSHLCMCAEGYAL 347
Score = 40.7 bits (91), Expect = 0.031
Identities = 63/323 (19%), Positives = 130/323 (40%), Gaps = 29/323 (8%)
Query: 605 EPEAFLVYSRKNIIGRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINR 664
E + V + ++ R+ + + V I+ K VS +A+ ++ WS+ + I
Sbjct: 85 EKRIYWVDLERQLLQRVFLNGSRQERVCNIE--KNVSGMAINWINEEVIWSNQQEGIITV 142
Query: 665 CSVNGSAVEKIVEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKK 724
+ G+ ++ L +A+D + I+W+ + + LDG +A++ + +K
Sbjct: 143 TDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALL-ETSEK 201
Query: 725 PKSIVLDPKKGYMYWSEL---GSKS-IKRAAMDGSSVSVFMEQVGR-VHALAIDYERRAI 779
++ LD ++W + GS S I DG SV + + A+++ +R I
Sbjct: 202 ITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDR--I 259
Query: 780 YWAALDPPVVEFAFLNGTGRQTLADN-----IPM-------PYALALFNDSVYWGDWNTG 827
+++ + A + TG+ + N +P+ P A D + +
Sbjct: 260 FYSTWKMKTIWIANKH-TGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLC 318
Query: 828 QIQQARKTDGSNRKSIRKDLDYISDLKLYHRAKSMGS--NQCGVDNGGCSHLCLPTPGDV 885
++++ + + ++ L ++ R + N+C N GC+ C TPG
Sbjct: 319 KLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPG-- 376
Query: 886 RTDYRCACPAHYRLNKDNITCSE 908
Y C CP + L D C +
Sbjct: 377 --SYYCTCPVGFVLLPDGKRCHQ 397
Score = 36.7 bits (81), Expect = 0.50
Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 6/95 (6%)
Query: 922 GRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXX 981
G I V + + N+++I L+ LK + DPVE+ ++W + + S+ R +
Sbjct: 138 GIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALLE 197
Query: 982 XXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINA 1016
+S LDVL + ++W +R+ N+
Sbjct: 198 TSEKITAVS------LDVLDKRLFWIQYNREGSNS 226
Score = 33.9 bits (74), Expect = 3.5
Identities = 22/89 (24%), Positives = 47/89 (52%), Gaps = 5/89 (5%)
Query: 167 IYWVDAKLQFVDVIDFNGEKRKRVVKGGLVYP--FALTFSNDKLYWTDWQNWSIYTWDIA 224
IY+ L++++ + +G +R+R+++ G+ P A+ + + YWTD I D+
Sbjct: 526 IYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDL- 584
Query: 225 ANGPKIKELIKSH-PVPADIKVYDESRQI 252
NG + K + K + P I V+ ++++
Sbjct: 585 -NGKRSKIITKENISQPRGIAVHPMAKRL 612
Score = 33.1 bits (72), Expect = 6.2
Identities = 28/137 (20%), Positives = 52/137 (37%), Gaps = 7/137 (5%)
Query: 940 GLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDV 999
G+ + D + ++ YW D I R ++ +S+P + +
Sbjct: 553 GVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLN-----GKRSKIITKENISQPRGIAVHP 607
Query: 1000 LGRTMYWTCAD-RDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGAI 1058
+ + ++WT I ++S+ VI D + P + L W D + I
Sbjct: 608 MAKRLFWTDTGINPRIESSSLQGLGRL-VIASSDLIWPSGITIDFLTDKLYWCDAKQSVI 666
Query: 1059 MRANVDGTGRVELARAD 1075
AN+DG+ R L + D
Sbjct: 667 EMANLDGSKRRRLTQND 683
>BC093731-1|AAH93731.1| 1207|Homo sapiens epidermal growth factor
(beta-urogastrone) protein.
Length = 1207
Score = 203 bits (495), Expect = 3e-51
Identities = 111/343 (32%), Positives = 167/343 (48%), Gaps = 5/343 (1%)
Query: 263 NNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDSP 322
+N GCS LC+ P + C C G L+ + + PQ L+ A I + D
Sbjct: 443 DNGGCSQLCV-PLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGT 501
Query: 323 DFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSS-GVPDS 381
D+ TL + + +D DP IY+A K I +A +DGS + ++ VP+
Sbjct: 502 DYG--TLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEG 559
Query: 382 IAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNE 441
+A+D + R+ YWTD I + L+G K+I + PR IA+H A +FW+D
Sbjct: 560 LAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGI 619
Query: 442 KKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKE 501
P+IE ++L G GR+++ S L WP+ I +D + +KLYW DA+ IE+ N+DG++R+
Sbjct: 620 N-PRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRR 678
Query: 502 LHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFRLGA 561
L ND+ H F ++ R+NK TG DR + M + A
Sbjct: 679 LTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVRLQGSMLKPSSLVVVHPLA 738
Query: 562 PLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
G +PC NGGC H+C R C C G +D KTC+
Sbjct: 739 KPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCL 781
Score = 157 bits (382), Expect = 2e-37
Identities = 95/343 (27%), Positives = 167/343 (48%), Gaps = 12/343 (3%)
Query: 571 DNGGCSHLCFN-RPDDYICGCPLGLELTADKKTCVE--PEAFLVYSRKNIIGRLSIKNEY 627
DNGGCS LC P + C C G +L D+K+C P+ FL+++ I +
Sbjct: 443 DNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTD 502
Query: 628 NDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVE-WLGLVEGLA 686
++ + + V AL +K+Y++ + K I R +++GS E+++E + + EGLA
Sbjct: 503 YGTLLS-QQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLA 561
Query: 687 IDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELG-SK 745
+DW G+ YWTD I S L+G + I + + +P+ I + P ++W++ G +
Sbjct: 562 VDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINP 621
Query: 746 SIKRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLAD 804
I+ +++ G + + + + ID+ +YW V+E A L+G+ R+ L
Sbjct: 622 RIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQ 681
Query: 805 N-IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHRAKSMG 863
N + P+A+A+F D V++ DW + + K G +R ++ + S L + H G
Sbjct: 682 NDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKPG 741
Query: 864 SNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
++ C NGGC H+C G C+C + D TC
Sbjct: 742 ADPCLYQNGGCEHICKKRLGTA----WCSCREGFMKASDGKTC 780
Score = 128 bits (309), Expect = 1e-28
Identities = 71/253 (28%), Positives = 124/253 (49%), Gaps = 9/253 (3%)
Query: 54 EKFKIVSEGLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIA 113
++ +++ EG+ P G+A+DW + YWTD + I + K K++ + R IA
Sbjct: 545 QRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIA 604
Query: 114 VVPEDGLMFWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAK 173
V P +FWTD G P+IE + + G R VI ++ WP+GIT+D+ +YW DAK
Sbjct: 605 VHPMAKRLFWTDTGINPRIESSSLQG--LGRLVIASSDLIWPSGITIDFLTDKLYWCDAK 662
Query: 174 LQFVDVIDFNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKEL 233
+++ + +G KR+R+ + + +PFA+ D ++++DW S+ + +++ L
Sbjct: 663 QSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVR-L 721
Query: 234 IKSHPVPADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTG-VKLRE 292
S P+ + V + PC N GC H+C C+C G +K +
Sbjct: 722 QGSMLKPSSLVVV---HPLAKPGADPCLYQNGGCEHICKKRLGTAW--CSCREGFMKASD 776
Query: 293 NSSTTCYDSPQML 305
+ D Q+L
Sbjct: 777 GKTCLALDGHQLL 789
Score = 108 bits (260), Expect = 1e-22
Identities = 78/340 (22%), Positives = 148/340 (43%), Gaps = 26/340 (7%)
Query: 590 CPLGLELTADKKTCVEPEAFLVYSRKNIIGRLSIKN-EYNDAVIPIKDLKEVSALALYVS 648
CP G TCV P FL++S N I R+ + Y V+ D + + +
Sbjct: 28 CPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQLVV---DAGVSVIMDFHYN 84
Query: 649 GSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSR 708
++YW D + + + R +NGS E++ V G+AI+W + + W++ I V+
Sbjct: 85 EKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSGMAINWINEEVIWSNQQEGIITVTD 144
Query: 709 LDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKSIKRAAMDGSSVSVFMEQVGRVH 768
+ G++ I+ LK P ++ +DP + +++WS + S+ RA +DG V +E ++
Sbjct: 145 MKGNNSH-ILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALLETSEKIT 203
Query: 769 ALAIDYERRAIYWAALDPP-----VVEFAFLNGTGRQTLADNIPMPYALALFNDSVYWGD 823
A+++D + ++W + + + G+ + +A++LF D +++
Sbjct: 204 AVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYST 263
Query: 824 WNTGQIQQARKTDGSN--RKSIRKDLDYISDLKLYHRAKSMGSNQ---------CGVDNG 872
W I A K G + R ++ + +LK+ H + C + G
Sbjct: 264 WKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKG 323
Query: 873 GCSH-LCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
CS +C G + C C Y L++D C + E
Sbjct: 324 NCSSTVC----GQDLQSHLCMCAEGYALSRDRKYCEDVNE 359
Score = 82.2 bits (194), Expect = 1e-14
Identities = 80/340 (23%), Positives = 147/340 (43%), Gaps = 31/340 (9%)
Query: 283 ACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRTLTVDF 342
+CP G L N ++TC P L+ + ++I +I + T Y + D ++ +DF
Sbjct: 27 SCPEGT-LAGNGNSTCV-GPAPFLIFSHGNSIFRIDTEG---TNYEQLVVDAGVSVIMDF 81
Query: 343 DPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGVPDSIAIDPLSRKIYWTDPVMDTIN 402
+ IYW D + + + L+GS Q V +AI+ ++ ++ W++ I
Sbjct: 82 HYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSGMAINWINEEVIWSNQQEGIIT 141
Query: 403 VARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSG--RVLLI 460
V + G+ +++ Y P +A+ ++FWS +E + RA+LDG G +L
Sbjct: 142 VTDMKGNNSHILLSALKY-PANVAVDPVERFIFWS--SEVAGSLYRADLDGVGVKALLET 198
Query: 461 SEKLTWPNSIALDTVNNKLYW----GDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXX 516
SEK+T +++LD ++ +L+W + I C+ DG ++F
Sbjct: 199 SEKIT---AVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLF 255
Query: 517 XXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFRLGAPLG--------WNP- 567
+ +T+ NK+TG D + ++ + + ++ PL W P
Sbjct: 256 GDRIFYSTWKMKTIWIANKHTGKD-MVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPE 314
Query: 568 ---CADDNGGCSH-LCFNRPDDYICGCPLGLELTADKKTC 603
C G CS +C ++C C G L+ D+K C
Sbjct: 315 QKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYC 354
Score = 81.4 bits (192), Expect = 2e-14
Identities = 65/252 (25%), Positives = 118/252 (46%), Gaps = 13/252 (5%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKL-RENSSTTCYDSPQMLLVVAQRSTISKIS 318
C +N + CSH C+L+ + P C CP G L R+ + + SP +S +S
Sbjct: 401 CPRNVSECSHDCVLTSEGP--LCFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVS 458
Query: 319 LDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVV-RSSG 377
+ F Y L L D K P ++ +A+ ++ I DG+D ++ + G
Sbjct: 459 WECDCFPGYDLQL-DEKSCAASGPQP---FLLFAN--SQDIRHMHFDGTDYGTLLSQQMG 512
Query: 378 VPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWS 437
+ ++ DP+ KIY+ + I A +DGS + +I + P +A+ +W+
Sbjct: 513 MVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWT 572
Query: 438 DWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTH-KIEVCNMDG 496
D K I R++L+G ++ E ++ P IA+ + +L+W D + +IE ++ G
Sbjct: 573 D--RGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQG 630
Query: 497 TERKELHSNDII 508
R + S+D+I
Sbjct: 631 LGRLVIASSDLI 642
Score = 72.1 bits (169), Expect = 1e-11
Identities = 61/271 (22%), Positives = 115/271 (42%), Gaps = 17/271 (6%)
Query: 347 EYIYWADGLAKTISKARLDGSDQSVVVRSSGVPDSIAIDPLSRKIYWTDPVMDTINVARL 406
E + W++ I+ + G++ +++ + P ++A+DP+ R I+W+ V ++ A L
Sbjct: 128 EEVIWSNQQEGIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADL 187
Query: 407 DGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTW 466
DG K ++ T A++L + +FW +N + + D G + IS+ T
Sbjct: 188 DGVGVKALLETS-EKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQ 246
Query: 467 PNSIALDTVNNKLYWGDARTHKIEVCNMD-GTE--RKELHSN-------DIIHIFGXXXX 516
N A+ +++++ + I + N G + R LHS+ ++H
Sbjct: 247 HNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKA 306
Query: 517 XXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFRLGAPLGW----NPCADDN 572
+ L + N ++ + Q + + M + + L + N CA N
Sbjct: 307 EDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLC--MCAEGYALSRDRKYCEDVNECAFWN 364
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
GC+ C N P Y C CP+G L D K C
Sbjct: 365 HGCTLGCKNTPGSYYCTCPVGFVLLPDGKRC 395
Score = 64.5 bits (150), Expect = 2e-09
Identities = 46/201 (22%), Positives = 89/201 (44%), Gaps = 12/201 (5%)
Query: 892 ACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDP 951
+CP N TC P FL+F+ N++ RI G + + G+ + Y+
Sbjct: 27 SCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDT-EGTNYEQLVVDAGVSVIMDFHYN- 84
Query: 952 VEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADR 1011
EK++YW+D + ++RV ++ G M ++ + + W+
Sbjct: 85 -EKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSG------MAINWINEEVIWSNQQE 137
Query: 1012 DSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGAIMRANVDGTG-RVE 1070
I T + N+S I+ P ++A +R++ W+ G++ RA++DG G +
Sbjct: 138 GIITVTDMKGNNSH--ILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKAL 195
Query: 1071 LARADNATALALDQSAGTVYW 1091
L ++ TA++LD ++W
Sbjct: 196 LETSEKITAVSLDVLDKRLFW 216
Score = 57.2 bits (132), Expect = 3e-07
Identities = 40/140 (28%), Positives = 65/140 (46%), Gaps = 6/140 (4%)
Query: 76 DKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERA 135
+K+Y+ IE ++ R+ L VD+ +AV +WTD G+ I R+
Sbjct: 524 NKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGK-SLIGRS 582
Query: 136 GMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQ-FVDVIDFNGEKRKRVVKGG 194
+NG + K+I ++NI P GI V ++W D + ++ G R +
Sbjct: 583 DLNGKRS--KIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSD 640
Query: 195 LVYPFALT--FSNDKLYWTD 212
L++P +T F DKLYW D
Sbjct: 641 LIWPSGITIDFLTDKLYWCD 660
Score = 52.8 bits (121), Expect = 7e-06
Identities = 61/298 (20%), Positives = 124/298 (41%), Gaps = 29/298 (9%)
Query: 8 TRITTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPT 67
T + D +DFHY + I W D + +L+Q + N G + + V +
Sbjct: 64 TNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLN----GSRQERVCNIEKNVS 119
Query: 68 GIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWG 127
G+AI+W +++ W++ + I V + +L S + +AV P + +FW+
Sbjct: 120 GMAINWINEEVIWSNQQEGIITVTDMKGNNSHILL-SALKYPANVAVDPVERFIFWS--S 176
Query: 128 EIP-KIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWV----DAKLQFVDVIDF 182
E+ + RA ++G + + I +++D + ++W+ + + D+
Sbjct: 177 EVAGSLYRADLDGVGVKALLETSEKI---TAVSLDVLDKRLFWIQYNREGSNSLICSCDY 233
Query: 183 NGEK---RKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPV 239
+G K + L FA++ D+++++ W+ +I+ + ++ + S V
Sbjct: 234 DGGSVHISKHPTQHNL---FAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFV 290
Query: 240 P-ADIKVYDESRQIISAED--YP----CKKNNAGCSHLCLLSPDPPGYNCACPTGVKL 290
P ++KV Q + +D P CK CS + D + C C G L
Sbjct: 291 PLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSS-TVCGQDLQSHLCMCAEGYAL 347
Score = 40.7 bits (91), Expect = 0.031
Identities = 63/323 (19%), Positives = 130/323 (40%), Gaps = 29/323 (8%)
Query: 605 EPEAFLVYSRKNIIGRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINR 664
E + V + ++ R+ + + V I+ K VS +A+ ++ WS+ + I
Sbjct: 85 EKRIYWVDLERQLLQRVFLNGSRQERVCNIE--KNVSGMAINWINEEVIWSNQQEGIITV 142
Query: 665 CSVNGSAVEKIVEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKK 724
+ G+ ++ L +A+D + I+W+ + + LDG +A++ + +K
Sbjct: 143 TDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALL-ETSEK 201
Query: 725 PKSIVLDPKKGYMYWSEL---GSKS-IKRAAMDGSSVSVFMEQVGR-VHALAIDYERRAI 779
++ LD ++W + GS S I DG SV + + A+++ +R I
Sbjct: 202 ITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDR--I 259
Query: 780 YWAALDPPVVEFAFLNGTGRQTLADN-----IPM-------PYALALFNDSVYWGDWNTG 827
+++ + A + TG+ + N +P+ P A D + +
Sbjct: 260 FYSTWKMKTIWIANKH-TGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLC 318
Query: 828 QIQQARKTDGSNRKSIRKDLDYISDLKLYHRAKSMGS--NQCGVDNGGCSHLCLPTPGDV 885
++++ + + ++ L ++ R + N+C N GC+ C TPG
Sbjct: 319 KLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPG-- 376
Query: 886 RTDYRCACPAHYRLNKDNITCSE 908
Y C CP + L D C +
Sbjct: 377 --SYYCTCPVGFVLLPDGKRCHQ 397
Score = 36.7 bits (81), Expect = 0.50
Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 6/95 (6%)
Query: 922 GRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXX 981
G I V + + N+++I L+ LK + DPVE+ ++W + + S+ R +
Sbjct: 138 GIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALLE 197
Query: 982 XXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINA 1016
+S LDVL + ++W +R+ N+
Sbjct: 198 TSEKITAVS------LDVLDKRLFWIQYNREGSNS 226
Score = 33.9 bits (74), Expect = 3.5
Identities = 22/89 (24%), Positives = 47/89 (52%), Gaps = 5/89 (5%)
Query: 167 IYWVDAKLQFVDVIDFNGEKRKRVVKGGLVYP--FALTFSNDKLYWTDWQNWSIYTWDIA 224
IY+ L++++ + +G +R+R+++ G+ P A+ + + YWTD I D+
Sbjct: 526 IYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDL- 584
Query: 225 ANGPKIKELIKSH-PVPADIKVYDESRQI 252
NG + K + K + P I V+ ++++
Sbjct: 585 -NGKRSKIITKENISQPRGIAVHPMAKRL 612
Score = 33.1 bits (72), Expect = 6.2
Identities = 28/137 (20%), Positives = 52/137 (37%), Gaps = 7/137 (5%)
Query: 940 GLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDV 999
G+ + D + ++ YW D I R ++ +S+P + +
Sbjct: 553 GVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLN-----GKRSKIITKENISQPRGIAVHP 607
Query: 1000 LGRTMYWTCAD-RDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGAI 1058
+ + ++WT I ++S+ VI D + P + L W D + I
Sbjct: 608 MAKRLFWTDTGINPRIESSSLQGLGRL-VIASSDLIWPSGITIDFLTDKLYWCDAKQSVI 666
Query: 1059 MRANVDGTGRVELARAD 1075
AN+DG+ R L + D
Sbjct: 667 EMANLDGSKRRRLTQND 683
>AY506357-1|AAR84237.1| 1152|Homo sapiens truncated epidermal growth
factor (beta-urogastrone) protein.
Length = 1152
Score = 203 bits (495), Expect = 3e-51
Identities = 111/343 (32%), Positives = 167/343 (48%), Gaps = 5/343 (1%)
Query: 263 NNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDSP 322
+N GCS LC+ P + C C G L+ + + PQ L+ A I + D
Sbjct: 443 DNGGCSQLCV-PLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGT 501
Query: 323 DFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSS-GVPDS 381
D+ TL + + +D DP IY+A K I +A +DGS + ++ VP+
Sbjct: 502 DYG--TLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEG 559
Query: 382 IAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNE 441
+A+D + R+ YWTD I + L+G K+I + PR IA+H A +FW+D
Sbjct: 560 LAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGI 619
Query: 442 KKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKE 501
P+IE ++L G GR+++ S L WP+ I +D + +KLYW DA+ IE+ N+DG++R+
Sbjct: 620 N-PRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRR 678
Query: 502 LHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFRLGA 561
L ND+ H F ++ R+NK TG DR + M + A
Sbjct: 679 LTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVRLQGSMLKPSSLVVVHPLA 738
Query: 562 PLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
G +PC NGGC H+C R C C G +D KTC+
Sbjct: 739 KPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCL 781
Score = 157 bits (382), Expect = 2e-37
Identities = 95/343 (27%), Positives = 167/343 (48%), Gaps = 12/343 (3%)
Query: 571 DNGGCSHLCFN-RPDDYICGCPLGLELTADKKTCVE--PEAFLVYSRKNIIGRLSIKNEY 627
DNGGCS LC P + C C G +L D+K+C P+ FL+++ I +
Sbjct: 443 DNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTD 502
Query: 628 NDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVE-WLGLVEGLA 686
++ + + V AL +K+Y++ + K I R +++GS E+++E + + EGLA
Sbjct: 503 YGTLLS-QQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLA 561
Query: 687 IDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELG-SK 745
+DW G+ YWTD I S L+G + I + + +P+ I + P ++W++ G +
Sbjct: 562 VDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINP 621
Query: 746 SIKRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLAD 804
I+ +++ G + + + + ID+ +YW V+E A L+G+ R+ L
Sbjct: 622 RIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQ 681
Query: 805 N-IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHRAKSMG 863
N + P+A+A+F D V++ DW + + K G +R ++ + S L + H G
Sbjct: 682 NDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKPG 741
Query: 864 SNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
++ C NGGC H+C G C+C + D TC
Sbjct: 742 ADPCLYQNGGCEHICKKRLGTA----WCSCREGFMKASDGKTC 780
Score = 128 bits (309), Expect = 1e-28
Identities = 71/253 (28%), Positives = 124/253 (49%), Gaps = 9/253 (3%)
Query: 54 EKFKIVSEGLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIA 113
++ +++ EG+ P G+A+DW + YWTD + I + K K++ + R IA
Sbjct: 545 QRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIA 604
Query: 114 VVPEDGLMFWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAK 173
V P +FWTD G P+IE + + G R VI ++ WP+GIT+D+ +YW DAK
Sbjct: 605 VHPMAKRLFWTDTGINPRIESSSLQG--LGRLVIASSDLIWPSGITIDFLTDKLYWCDAK 662
Query: 174 LQFVDVIDFNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKEL 233
+++ + +G KR+R+ + + +PFA+ D ++++DW S+ + +++ L
Sbjct: 663 QSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVR-L 721
Query: 234 IKSHPVPADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTG-VKLRE 292
S P+ + V + PC N GC H+C C+C G +K +
Sbjct: 722 QGSMLKPSSLVVV---HPLAKPGADPCLYQNGGCEHICKKRLGTAW--CSCREGFMKASD 776
Query: 293 NSSTTCYDSPQML 305
+ D Q+L
Sbjct: 777 GKTCLALDGHQLL 789
Score = 108 bits (260), Expect = 1e-22
Identities = 78/340 (22%), Positives = 148/340 (43%), Gaps = 26/340 (7%)
Query: 590 CPLGLELTADKKTCVEPEAFLVYSRKNIIGRLSIKN-EYNDAVIPIKDLKEVSALALYVS 648
CP G TCV P FL++S N I R+ + Y V+ D + + +
Sbjct: 28 CPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQLVV---DAGVSVIMDFHYN 84
Query: 649 GSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSR 708
++YW D + + + R +NGS E++ V G+AI+W + + W++ I V+
Sbjct: 85 EKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSGMAINWINEEVIWSNQQEGIITVTD 144
Query: 709 LDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKSIKRAAMDGSSVSVFMEQVGRVH 768
+ G++ I+ LK P ++ +DP + +++WS + S+ RA +DG V +E ++
Sbjct: 145 MKGNNSH-ILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALLETSEKIT 203
Query: 769 ALAIDYERRAIYWAALDPP-----VVEFAFLNGTGRQTLADNIPMPYALALFNDSVYWGD 823
A+++D + ++W + + + G+ + +A++LF D +++
Sbjct: 204 AVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYST 263
Query: 824 WNTGQIQQARKTDGSN--RKSIRKDLDYISDLKLYHRAKSMGSNQ---------CGVDNG 872
W I A K G + R ++ + +LK+ H + C + G
Sbjct: 264 WKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKG 323
Query: 873 GCSH-LCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
CS +C G + C C Y L++D C + E
Sbjct: 324 NCSSTVC----GQDLQSHLCMCAEGYALSRDRKYCEDVNE 359
Score = 82.2 bits (194), Expect = 1e-14
Identities = 80/340 (23%), Positives = 147/340 (43%), Gaps = 31/340 (9%)
Query: 283 ACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRTLTVDF 342
+CP G L N ++TC P L+ + ++I +I + T Y + D ++ +DF
Sbjct: 27 SCPEGT-LAGNGNSTCV-GPAPFLIFSHGNSIFRIDTEG---TNYEQLVVDAGVSVIMDF 81
Query: 343 DPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGVPDSIAIDPLSRKIYWTDPVMDTIN 402
+ IYW D + + + L+GS Q V +AI+ ++ ++ W++ I
Sbjct: 82 HYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSGMAINWINEEVIWSNQQEGIIT 141
Query: 403 VARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSG--RVLLI 460
V + G+ +++ Y P +A+ ++FWS +E + RA+LDG G +L
Sbjct: 142 VTDMKGNNSHILLSALKY-PANVAVDPVERFIFWS--SEVAGSLYRADLDGVGVKALLET 198
Query: 461 SEKLTWPNSIALDTVNNKLYW----GDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXX 516
SEK+T +++LD ++ +L+W + I C+ DG ++F
Sbjct: 199 SEKIT---AVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLF 255
Query: 517 XXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFRLGAPLG--------WNP- 567
+ +T+ NK+TG D + ++ + + ++ PL W P
Sbjct: 256 GDRIFYSTWKMKTIWIANKHTGKD-MVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPE 314
Query: 568 ---CADDNGGCSH-LCFNRPDDYICGCPLGLELTADKKTC 603
C G CS +C ++C C G L+ D+K C
Sbjct: 315 QKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYC 354
Score = 81.4 bits (192), Expect = 2e-14
Identities = 65/252 (25%), Positives = 118/252 (46%), Gaps = 13/252 (5%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKL-RENSSTTCYDSPQMLLVVAQRSTISKIS 318
C +N + CSH C+L+ + P C CP G L R+ + + SP +S +S
Sbjct: 401 CPRNVSECSHDCVLTSEGP--LCFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVS 458
Query: 319 LDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVV-RSSG 377
+ F Y L L D K P ++ +A+ ++ I DG+D ++ + G
Sbjct: 459 WECDCFPGYDLQL-DEKSCAASGPQP---FLLFAN--SQDIRHMHFDGTDYGTLLSQQMG 512
Query: 378 VPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWS 437
+ ++ DP+ KIY+ + I A +DGS + +I + P +A+ +W+
Sbjct: 513 MVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWT 572
Query: 438 DWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTH-KIEVCNMDG 496
D K I R++L+G ++ E ++ P IA+ + +L+W D + +IE ++ G
Sbjct: 573 D--RGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQG 630
Query: 497 TERKELHSNDII 508
R + S+D+I
Sbjct: 631 LGRLVIASSDLI 642
Score = 72.1 bits (169), Expect = 1e-11
Identities = 61/271 (22%), Positives = 115/271 (42%), Gaps = 17/271 (6%)
Query: 347 EYIYWADGLAKTISKARLDGSDQSVVVRSSGVPDSIAIDPLSRKIYWTDPVMDTINVARL 406
E + W++ I+ + G++ +++ + P ++A+DP+ R I+W+ V ++ A L
Sbjct: 128 EEVIWSNQQEGIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADL 187
Query: 407 DGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTW 466
DG K ++ T A++L + +FW +N + + D G + IS+ T
Sbjct: 188 DGVGVKALLETS-EKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQ 246
Query: 467 PNSIALDTVNNKLYWGDARTHKIEVCNMD-GTE--RKELHSN-------DIIHIFGXXXX 516
N A+ +++++ + I + N G + R LHS+ ++H
Sbjct: 247 HNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKA 306
Query: 517 XXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFRLGAPLGW----NPCADDN 572
+ L + N ++ + Q + + M + + L + N CA N
Sbjct: 307 EDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLC--MCAEGYALSRDRKYCEDVNECAFWN 364
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
GC+ C N P Y C CP+G L D K C
Sbjct: 365 HGCTLGCKNTPGSYYCTCPVGFVLLPDGKRC 395
Score = 64.5 bits (150), Expect = 2e-09
Identities = 46/201 (22%), Positives = 89/201 (44%), Gaps = 12/201 (5%)
Query: 892 ACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDP 951
+CP N TC P FL+F+ N++ RI G + + G+ + Y+
Sbjct: 27 SCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDT-EGTNYEQLVVDAGVSVIMDFHYN- 84
Query: 952 VEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADR 1011
EK++YW+D + ++RV ++ G M ++ + + W+
Sbjct: 85 -EKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSG------MAINWINEEVIWSNQQE 137
Query: 1012 DSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGAIMRANVDGTG-RVE 1070
I T + N+S I+ P ++A +R++ W+ G++ RA++DG G +
Sbjct: 138 GIITVTDMKGNNSH--ILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKAL 195
Query: 1071 LARADNATALALDQSAGTVYW 1091
L ++ TA++LD ++W
Sbjct: 196 LETSEKITAVSLDVLDKRLFW 216
Score = 57.2 bits (132), Expect = 3e-07
Identities = 40/140 (28%), Positives = 65/140 (46%), Gaps = 6/140 (4%)
Query: 76 DKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERA 135
+K+Y+ IE ++ R+ L VD+ +AV +WTD G+ I R+
Sbjct: 524 NKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGK-SLIGRS 582
Query: 136 GMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQ-FVDVIDFNGEKRKRVVKGG 194
+NG + K+I ++NI P GI V ++W D + ++ G R +
Sbjct: 583 DLNGKRS--KIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSD 640
Query: 195 LVYPFALT--FSNDKLYWTD 212
L++P +T F DKLYW D
Sbjct: 641 LIWPSGITIDFLTDKLYWCD 660
Score = 52.8 bits (121), Expect = 7e-06
Identities = 61/298 (20%), Positives = 124/298 (41%), Gaps = 29/298 (9%)
Query: 8 TRITTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPT 67
T + D +DFHY + I W D + +L+Q + N G + + V +
Sbjct: 64 TNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLN----GSRQERVCNIEKNVS 119
Query: 68 GIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWG 127
G+AI+W +++ W++ + I V + +L S + +AV P + +FW+
Sbjct: 120 GMAINWINEEVIWSNQQEGIITVTDMKGNNSHILL-SALKYPANVAVDPVERFIFWS--S 176
Query: 128 EIP-KIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWV----DAKLQFVDVIDF 182
E+ + RA ++G + + I +++D + ++W+ + + D+
Sbjct: 177 EVAGSLYRADLDGVGVKALLETSEKI---TAVSLDVLDKRLFWIQYNREGSNSLICSCDY 233
Query: 183 NGEK---RKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPV 239
+G K + L FA++ D+++++ W+ +I+ + ++ + S V
Sbjct: 234 DGGSVHISKHPTQHNL---FAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFV 290
Query: 240 P-ADIKVYDESRQIISAED--YP----CKKNNAGCSHLCLLSPDPPGYNCACPTGVKL 290
P ++KV Q + +D P CK CS + D + C C G L
Sbjct: 291 PLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSS-TVCGQDLQSHLCMCAEGYAL 347
Score = 40.7 bits (91), Expect = 0.031
Identities = 63/323 (19%), Positives = 130/323 (40%), Gaps = 29/323 (8%)
Query: 605 EPEAFLVYSRKNIIGRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINR 664
E + V + ++ R+ + + V I+ K VS +A+ ++ WS+ + I
Sbjct: 85 EKRIYWVDLERQLLQRVFLNGSRQERVCNIE--KNVSGMAINWINEEVIWSNQQEGIITV 142
Query: 665 CSVNGSAVEKIVEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKK 724
+ G+ ++ L +A+D + I+W+ + + LDG +A++ + +K
Sbjct: 143 TDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALL-ETSEK 201
Query: 725 PKSIVLDPKKGYMYWSEL---GSKS-IKRAAMDGSSVSVFMEQVGR-VHALAIDYERRAI 779
++ LD ++W + GS S I DG SV + + A+++ +R I
Sbjct: 202 ITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDR--I 259
Query: 780 YWAALDPPVVEFAFLNGTGRQTLADN-----IPM-------PYALALFNDSVYWGDWNTG 827
+++ + A + TG+ + N +P+ P A D + +
Sbjct: 260 FYSTWKMKTIWIANKH-TGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLC 318
Query: 828 QIQQARKTDGSNRKSIRKDLDYISDLKLYHRAKSMGS--NQCGVDNGGCSHLCLPTPGDV 885
++++ + + ++ L ++ R + N+C N GC+ C TPG
Sbjct: 319 KLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPG-- 376
Query: 886 RTDYRCACPAHYRLNKDNITCSE 908
Y C CP + L D C +
Sbjct: 377 --SYYCTCPVGFVLLPDGKRCHQ 397
Score = 36.7 bits (81), Expect = 0.50
Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 6/95 (6%)
Query: 922 GRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXX 981
G I V + + N+++I L+ LK + DPVE+ ++W + + S+ R +
Sbjct: 138 GIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALLE 197
Query: 982 XXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINA 1016
+S LDVL + ++W +R+ N+
Sbjct: 198 TSEKITAVS------LDVLDKRLFWIQYNREGSNS 226
Score = 33.9 bits (74), Expect = 3.5
Identities = 22/89 (24%), Positives = 47/89 (52%), Gaps = 5/89 (5%)
Query: 167 IYWVDAKLQFVDVIDFNGEKRKRVVKGGLVYP--FALTFSNDKLYWTDWQNWSIYTWDIA 224
IY+ L++++ + +G +R+R+++ G+ P A+ + + YWTD I D+
Sbjct: 526 IYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDL- 584
Query: 225 ANGPKIKELIKSH-PVPADIKVYDESRQI 252
NG + K + K + P I V+ ++++
Sbjct: 585 -NGKRSKIITKENISQPRGIAVHPMAKRL 612
Score = 33.1 bits (72), Expect = 6.2
Identities = 28/137 (20%), Positives = 52/137 (37%), Gaps = 7/137 (5%)
Query: 940 GLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDV 999
G+ + D + ++ YW D I R ++ +S+P + +
Sbjct: 553 GVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLN-----GKRSKIITKENISQPRGIAVHP 607
Query: 1000 LGRTMYWTCAD-RDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGAI 1058
+ + ++WT I ++S+ VI D + P + L W D + I
Sbjct: 608 MAKRLFWTDTGINPRIESSSLQGLGRL-VIASSDLIWPSGITIDFLTDKLYWCDAKQSVI 666
Query: 1059 MRANVDGTGRVELARAD 1075
AN+DG+ R L + D
Sbjct: 667 EMANLDGSKRRRLTQND 683
>U04441-1|AAB02882.1| 1751|Homo sapiens glycoprotein 330 protein.
Length = 1751
Score = 199 bits (485), Expect = 6e-50
Identities = 112/340 (32%), Positives = 176/340 (51%), Gaps = 20/340 (5%)
Query: 575 CSHLCFNRPDDYICGCPLGLELTADKKTCVEP---EAFLVYSRKNIIGRLSIKNEYNDAV 631
CS C N YIC C G D KTC + E +L++S + + L+I + +
Sbjct: 460 CSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLI 519
Query: 632 IPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEW-LGLVEGLAIDWS 690
+ + L V AL +LYW D++ + I R +N + E I+ L E LA+DW
Sbjct: 520 L--EGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWV 577
Query: 691 GQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLK--------KPKSIVLDPKKGYMYWSEL 742
+ +YW D + VS L+G RR + + P+ + L P+ GY+YW++
Sbjct: 578 SRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADW 637
Query: 743 GSKS-IKRAAMDGSSVSVFME-QVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQ 800
G ++ I R MDG++ SV + ++ + + IDY +YWA +E++ L G R
Sbjct: 638 GHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRH 697
Query: 801 TLADN-IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHRA 859
T+ D +P P+A+ +F D++YW DWNT +++ K DGSNR+++ D+ +YH
Sbjct: 698 TVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPY 757
Query: 860 KS-MGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYR 898
+ + SN CG +NGGCSHLCL PG + C CP +R
Sbjct: 758 RQPIVSNPCGTNNGGCSHLCLIKPGG--KGFTCECPDDFR 795
Score = 192 bits (468), Expect = 6e-48
Identities = 103/295 (34%), Positives = 154/295 (52%), Gaps = 17/295 (5%)
Query: 13 IAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAID 72
I + L+ A+DF + + W D + ++I+ M N+T K I++ L +A+D
Sbjct: 519 ILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKT---NKETIINHRLPAAESLAVD 575
Query: 73 WYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDL--------ARAIAVVPEDGLMFWT 124
W + KLYW D + + V + +R++L VD R +A+ P+ G ++W
Sbjct: 576 WVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWA 635
Query: 125 DWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNG 184
DWG I R GM+G + VI+ + WPNGIT+DY N L+YW DA L +++ D G
Sbjct: 636 DWGHRAYIGRVGMDG--TNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEG 693
Query: 185 EKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIK 244
R V G L +PFA+T D +YWTDW ++ + +G + L+ + P DI
Sbjct: 694 HHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGN-KYDGSNRQTLVNTTHRPFDIH 752
Query: 245 VYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVK-LRENSSTTC 298
VY RQ I + PC NN GCSHLCL+ P G+ C CP + L+ + ST C
Sbjct: 753 VYHPYRQPIVSN--PCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYC 805
Score = 173 bits (422), Expect = 2e-42
Identities = 92/238 (38%), Positives = 139/238 (58%), Gaps = 13/238 (5%)
Query: 63 LVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMF 122
++ P GIA+DW +YW+D + +IEV + +YRK L +++D AIAV P+ GLMF
Sbjct: 1439 VMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMF 1498
Query: 123 WTDWGEIPKIERAGMNG-DPATRKVIVRDNIFWPNGITVDY-NNSLIYWVDAKLQFVDVI 180
WTDWG+ PK+E A MNG DP ++V +++ WP G+++DY NN IYW D K ++ I
Sbjct: 1499 WTDWGKEPKLESAWMNGEDP---NILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETI 1555
Query: 181 DFNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVP 240
++G R RV+ + P++L D+LYW + ++ + G K K L+ +P
Sbjct: 1556 KYDGTDR-RVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLV-VNPWL 1613
Query: 241 ADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTC 298
++++ + R S + CK+ CSHLCLL P GY+CACP G E S+T C
Sbjct: 1614 TQVRIFHQLRYNKSVPNL-CKQI---CSHLCLLRPG--GYSCACPQGSSFIEGSTTEC 1665
Score = 172 bits (418), Expect = 7e-42
Identities = 97/326 (29%), Positives = 164/326 (50%), Gaps = 19/326 (5%)
Query: 280 YNCACPTGVKLRENSSTTCYDSPQM--LLVVAQRSTISKISLDSPDFTPYTLPLKDLKRT 337
Y C C G LRE TC + + L+ + R + +++D Y+L L+ L
Sbjct: 471 YICKCAPGY-LREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYF---YSLILEGLDNV 526
Query: 338 LTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSS-GVPDSIAIDPLSRKIYWTDP 396
+ +DFD + +YW D + I + L+ +++ ++ +S+A+D +SRK+YW D
Sbjct: 527 VALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDA 586
Query: 397 VMDTINVARLDGSYEKVII-------HTELYD-PRAIALHLTAGWMFWSDWNEKKPKIER 448
+D + V+ L+G + +++ +T +D PR +ALH G+++W+DW + I R
Sbjct: 587 RLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRA-YIGR 645
Query: 449 ANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDII 508
+DG+ + ++IS KL WPN I +D N+ LYW DA IE +++G R ++ +
Sbjct: 646 VGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALP 705
Query: 509 HIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFR-LGAPLGWNP 567
H F RT+++ NK G +RQ +V + + P+ NP
Sbjct: 706 HPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNP 765
Query: 568 CADDNGGCSHLCFNRP--DDYICGCP 591
C +NGGCSHLC +P + C CP
Sbjct: 766 CGTNNGGCSHLCLIKPGGKGFTCECP 791
Score = 134 bits (324), Expect = 2e-30
Identities = 101/354 (28%), Positives = 173/354 (48%), Gaps = 33/354 (9%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADK--KTCV-EPEAFLVYSRKNI-IGRL 621
N C + G C C N Y C C G +D+ K C E + L+ N+ I +
Sbjct: 1307 NEC-EQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKY 1365
Query: 622 SIKNE----------YNDAVIPIKDLKEVSALALY--VSGSKLYWSDSKTKTI-NRCSVN 668
++ +E Y AV D +++ +Y V G + K I N S
Sbjct: 1366 NLSSERFSEYLQDEEYIQAVDYDWDPEDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGR 1425
Query: 669 GSAVEKI---VEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKP 725
+ V+++ ++++ +G+A+DW G++IYW+D +RIEV++LDG R+ +I L +P
Sbjct: 1426 NNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQP 1485
Query: 726 KSIVLDPKKGYMYWSELGSK-SIKRAAMDGSSVSVFM-EQVGRVHALAIDY-ERRAIYWA 782
+I ++PK G M+W++ G + ++ A M+G ++ + E +G L+IDY IYW+
Sbjct: 1486 AAIAVNPKLGLMFWTDWGKEPKLESAWMNGEDPNILVFEDLGWPTGLSIDYLNNDRIYWS 1545
Query: 783 ALDPPVVEFAFLNGTGRQTLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKS 842
V+E +GT R+ +A PY+L +F D +YW G++ + K ++
Sbjct: 1546 DFKEDVIETIKYDGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEK 1605
Query: 843 IRKDLDYISDLKLYHRAKSMGS--NQCGVDNGGCSHLCLPTPGDVRTDYRCACP 894
+++ ++++H+ + S N C CSHLCL PG Y CACP
Sbjct: 1606 TLVVNPWLTQVRIFHQLRYNKSVPNLC---KQICSHLCLLRPG----GYSCACP 1652
Score = 130 bits (313), Expect = 4e-29
Identities = 97/335 (28%), Positives = 158/335 (47%), Gaps = 27/335 (8%)
Query: 280 YNCACPTG-VKLRENSSTTCY-DSPQMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRT 337
Y C C G + + C + LL++ I K +L S F+ Y L ++ +
Sbjct: 1326 YECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEY-LQDEEYIQA 1384
Query: 338 LTVDFDPKT---EYIYWA---DGLA-KTISKARLDGSD-------QSVVVRSSGV--PDS 381
+ D+DP+ +Y+ +G I +A + + Q V ++ V PD
Sbjct: 1385 VDYDWDPEDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDG 1444
Query: 382 IAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNE 441
IA+D + R IYW+D I VA+LDG Y K +I T+L P AIA++ G MFW+DW
Sbjct: 1445 IAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWG- 1503
Query: 442 KKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNN-KLYWGDARTHKIEVCNMDGTERK 500
K+PK+E A ++G +L+ E L WP +++D +NN ++YW D + IE DGT+R+
Sbjct: 1504 KEPKLESAWMNGEDPNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRR 1563
Query: 501 ELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFRLG 560
+ + + ++ + +K + + NK ++ + + V+ F
Sbjct: 1564 VI-AKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFH-- 1620
Query: 561 APLGWNPCADD--NGGCSHLCFNRPDDYICGCPLG 593
L +N + CSHLC RP Y C CP G
Sbjct: 1621 -QLRYNKSVPNLCKQICSHLCLLRPGGYSCACPQG 1654
Score = 67.3 bits (157), Expect = 3e-10
Identities = 71/301 (23%), Positives = 127/301 (42%), Gaps = 29/301 (9%)
Query: 564 GWNPCADDN-GGCSHLCFNRPDDYICGCPLGLELTADKKTCVE----PEAFLVYSRK--N 616
G N C D + GC H C + + C C G +L +DK+TCV+ E V S+K N
Sbjct: 407 GINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCEN 466
Query: 617 IIGRLSIKNEYNDAVIPI-KDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKI 675
+IG K P K ++ S + Y+ S Y+ + +++G I
Sbjct: 467 VIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYY-------LRNLTIDGYFYSLI 519
Query: 676 VEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKG 735
+E L V L D + +YW DT Q IE L+ +++ II L +S+ +D
Sbjct: 520 LEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSR 579
Query: 736 YMYWSELGSKSIKRAAMDGSSVSVFMEQ---------VGRVHALAIDYERRAIYWAAL-D 785
+YW + + + ++G + + LA+ + +YWA
Sbjct: 580 KLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGH 639
Query: 786 PPVVEFAFLNGTGRQT-LADNIPMPYALAL--FNDSVYWGDWNTGQIQQARKTDGSNRKS 842
+ ++GT + ++ + P + + ND +YW D + G I+ + +G +R +
Sbjct: 640 RAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYS-DLEGHHRHT 698
Query: 843 I 843
+
Sbjct: 699 V 699
Score = 66.9 bits (156), Expect = 4e-10
Identities = 64/249 (25%), Positives = 103/249 (41%), Gaps = 24/249 (9%)
Query: 860 KSMGSNQCGVDNGGCSHL---CLPTPGDVRTDYRCACPAHYRLNKDNITC---SEPEEFL 913
K M + VD C+ + C +V Y C C Y D TC S E +L
Sbjct: 439 KLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYL 498
Query: 914 LFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISY 973
+F+ + + R + +G + L GL NV A+++D VEK+LYW+D I R+ ++
Sbjct: 499 IFSNRYYL-RNLTIDGYFYS--LILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLN- 554
Query: 974 XXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGV---IVR 1030
L + +D + R +YW A D + + ++ + V
Sbjct: 555 ----KTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVD 610
Query: 1031 GDRML----PRHLAFHQTKRYLIWNDVG-RGAIMRANVDGTGR--VELARADNATALALD 1083
+ PR LA H YL W D G R I R +DGT + + + + + +D
Sbjct: 611 ANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITID 670
Query: 1084 QSAGTVYWA 1092
+ +YWA
Sbjct: 671 YTNDLLYWA 679
Score = 53.2 bits (122), Expect = 5e-06
Identities = 42/190 (22%), Positives = 82/190 (43%), Gaps = 13/190 (6%)
Query: 35 SDQKPELIQCMNY---NETYTGEKFKIVSEGLVTPTGIAIDWYTDKLYWTDGETNKIEVI 91
S+ +P LI Y N T G + ++ EGL + D +LYW D + IE +
Sbjct: 492 SNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERM 551
Query: 92 SIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERAGMNGD---PATRKVIV 148
+ + ++ + + A ++AV ++W D + + + +NG + +
Sbjct: 552 FLNKTNKETIINHRLPAAESLAVDWVSRKLYWLD-ARLDGLFVSDLNGGHRRMLAQHCVD 610
Query: 149 RDNIFW---PNGITVDYNNSLIYWVD-AKLQFVDVIDFNGEKRKRVVKGGLVYPFALT-- 202
+N F P G+ + +YW D ++ + +G + ++ L +P +T
Sbjct: 611 ANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITID 670
Query: 203 FSNDKLYWTD 212
++ND LYW D
Sbjct: 671 YTNDLLYWAD 680
Score = 43.2 bits (97), Expect = 0.006
Identities = 62/276 (22%), Positives = 101/276 (36%), Gaps = 35/276 (12%)
Query: 834 KTDGSNRKSIRKDLDYISDLKLYHRAKSMGSNQCGVDN-GGCSHLCLPTPGDVRTDYRCA 892
K D + K +++ D K G N+C + GC H C D T + C+
Sbjct: 378 KCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISGCDHNCT----DTLTSFYCS 433
Query: 893 CPAHYRLNKDNITCSEPEEF----LLFAQK--NAVGRIMVANGECNDAYIPLTGLKNVRA 946
C Y+L D TC + +E + +QK N +G + +C Y+ K R
Sbjct: 434 CRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYIC---KCAPGYLREPDGKTCR- 489
Query: 947 IEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYW 1006
+ +E Y + + + +R + I GL + D + + +YW
Sbjct: 490 -QNSNIEP--YLIFSNRYYLRNLTID------GYFYSLILEGLDNVVALDFDRVEKRLYW 540
Query: 1007 TCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGAIMRANVDGT 1066
R I + N ++ I+ LA R L W D + ++++G
Sbjct: 541 IDTQRQVIERMFL-NKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGG 599
Query: 1067 GRVELAR----------ADNATALALDQSAGTVYWA 1092
R LA+ DN LAL G +YWA
Sbjct: 600 HRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWA 635
Score = 41.5 bits (93), Expect = 0.018
Identities = 28/92 (30%), Positives = 50/92 (54%), Gaps = 7/92 (7%)
Query: 13 IAKDLEQGTAVDFHYRKNLICWSD--QKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIA 70
I+ DL+Q A+ + + L+ W+D ++P+L E + +V E L PTG++
Sbjct: 1478 ISTDLDQPAAIAVNPKLGLMFWTDWGKEPKLESAWMNGE----DPNILVFEDLGWPTGLS 1533
Query: 71 IDWY-TDKLYWTDGETNKIEVISIVQKYRKVL 101
ID+ D++YW+D + + IE I R+V+
Sbjct: 1534 IDYLNNDRIYWSDFKEDVIETIKYDGTDRRVI 1565
Score = 41.1 bits (92), Expect = 0.023
Identities = 31/90 (34%), Positives = 36/90 (40%), Gaps = 27/90 (30%)
Query: 1090 YWAVSRQCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFR 1149
YW +CDG DC DG DE E C DV C + FR
Sbjct: 1156 YW----KCDGDDDCGDGSDE-ELHLCL-DVPC---------------------NSPNRFR 1188
Query: 1150 CDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
CD CI + VC+G C DG+DE C
Sbjct: 1189 CDNNRCIYSHEVCNGVDDCGDGTDETEEHC 1218
Score = 40.3 bits (90), Expect = 0.041
Identities = 30/109 (27%), Positives = 39/109 (35%), Gaps = 10/109 (9%)
Query: 1068 RVELARADNATALALDQSAGTVYWAVSRQCDGQQ-DCEDGRDEAEC-GACGGDVRCADGT 1125
RV L DN D S + + C + C GR + G C + C D +
Sbjct: 134 RVYLCDGDNDCG---DNSDENPTYCTTHTCSSSEFQCASGRCIPQTFGICDQETDCFDAS 190
Query: 1126 XXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
D F+CD G CI ++CDG C D SDE
Sbjct: 191 DEPSSCGHSERTCLS-----DEFKCDGGRCIPNEWICDGDNDCGDMSDE 234
Score = 39.9 bits (89), Expect = 0.054
Identities = 27/84 (32%), Positives = 31/84 (36%), Gaps = 21/84 (25%)
Query: 1096 QCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLC 1155
+CDG DC D DEA+C R DG F C +C
Sbjct: 1114 KCDGSADCLDASDEADC-----PTRFPDGAYCQATM----------------FECKNHVC 1152
Query: 1156 IAARFVCDGRPQCADGSDEAPAAC 1179
I + CDG C DGSDE C
Sbjct: 1153 IPPYWKCDGDDDCGDGSDEELHLC 1176
Score = 39.5 bits (88), Expect = 0.071
Identities = 17/37 (45%), Positives = 20/37 (54%), Gaps = 1/37 (2%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAACAYGHT 1184
F C G CI+ + CD C DGSDE + CA HT
Sbjct: 1 FTCSNGRCISEEWKCDNDNGCGDGSDEMESVCAL-HT 36
Score = 39.5 bits (88), Expect = 0.071
Identities = 16/32 (50%), Positives = 17/32 (53%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F C G CI+ FVCD C DGSDE C
Sbjct: 334 FTCQNGRCISKTFVCDEDNDCGDGSDELMHLC 365
Score = 38.7 bits (86), Expect = 0.12
Identities = 30/101 (29%), Positives = 38/101 (37%), Gaps = 16/101 (15%)
Query: 1096 QCDGQQDCEDGRDE-AECGA--CG-GDVRCADGTXXXXXXXXXXXXXXXXXXXXD----- 1146
+CDGQ+DC DG DE A C C G +C+DG D
Sbjct: 828 KCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCE 887
Query: 1147 -------AFRCDEGLCIAARFVCDGRPQCADGSDEAPAACA 1180
++C CI + CD C D SDE + CA
Sbjct: 888 NHHCDSNEWQCANKRCIPESWQCDSFNDCEDNSDEDSSHCA 928
Score = 38.7 bits (86), Expect = 0.12
Identities = 38/153 (24%), Positives = 74/153 (48%), Gaps = 13/153 (8%)
Query: 20 GTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAIDWYTDKLY 79
G AVD+ R I WSD K + I+ + Y K+ ++S L P IA++ ++
Sbjct: 1444 GIAVDWVGRH--IYWSDVKNKRIEVAKLDGRY--RKW-LISTDLDQPAAIAVNPKLGLMF 1498
Query: 80 WTD-GETNKIEVISIVQKYRKVLFWSEVDLARAIAV-VPEDGLMFWTDWGEIPKIERAGM 137
WTD G+ K+E + + +L + ++ +++ + ++W+D+ E IE
Sbjct: 1499 WTDWGKEPKLESAWMNGEDPNILVFEDLGWPTGLSIDYLNNDRIYWSDFKE-DVIETIKY 1557
Query: 138 NGDPATRKVIVRDNIFWPNGITVDYNNSLIYWV 170
+G R+VI ++ + N ++D +YW+
Sbjct: 1558 DG--TDRRVIAKEAM---NPYSLDIFEDQLYWI 1585
Score = 37.9 bits (84), Expect = 0.22
Identities = 14/38 (36%), Positives = 20/38 (52%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAACAYGHTD 1185
F+C +G C + + +C+ C DGSDE C H D
Sbjct: 855 FQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCD 892
Score = 37.5 bits (83), Expect = 0.29
Identities = 22/72 (30%), Positives = 27/72 (37%), Gaps = 6/72 (8%)
Query: 1103 CEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVC 1162
C +GR +E C D C DG+ AF C G C+ + C
Sbjct: 3 CSNGRCISEEWKCDNDNGCGDGSDEMESVCALHTCSPT------AFTCANGRCVQYSYRC 56
Query: 1163 DGRPQCADGSDE 1174
D C DGSDE
Sbjct: 57 DYYNDCGDGSDE 68
Score = 37.5 bits (83), Expect = 0.29
Identities = 19/44 (43%), Positives = 21/44 (47%), Gaps = 3/44 (6%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDE---APAACAYGHTDQVN 1188
FRC CI R+ CDG+ C D SDE AP C VN
Sbjct: 1022 FRCKNHHCIPLRWKCDGQNDCGDNSDEENCAPRECTESEFRCVN 1065
Score = 36.3 bits (80), Expect = 0.66
Identities = 23/90 (25%), Positives = 33/90 (36%), Gaps = 4/90 (4%)
Query: 1100 QQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAAR 1159
Q C++GR ++ C D C DG+ F+CD G CI
Sbjct: 333 QFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHE----FKCDNGRCIEMM 388
Query: 1160 FVCDGRPQCADGSDEAPAACAYGHTDQVNG 1189
+C+ C D SDE H ++G
Sbjct: 389 KLCNHLDDCLDNSDEKGCGINECHDPSISG 418
Score = 33.9 bits (74), Expect = 3.5
Identities = 12/29 (41%), Positives = 16/29 (55%)
Query: 1151 DEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
+ +CI ++CDG C D SDE P C
Sbjct: 127 NSNICIPRVYLCDGDNDCGDNSDENPTYC 155
Score = 32.7 bits (71), Expect = 8.1
Identities = 16/34 (47%), Positives = 16/34 (47%), Gaps = 2/34 (5%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAACAY 1181
F C GLCI F CD C D SDE C Y
Sbjct: 295 FTCGYGLCIPKIFRCDRHNDCGDYSDE--RGCLY 326
>D86407-2|BAA21825.1| 793|Homo sapiens ApoER2delta4-7 protein.
Length = 793
Score = 185 bits (451), Expect = 7e-46
Identities = 105/308 (34%), Positives = 164/308 (53%), Gaps = 12/308 (3%)
Query: 17 LEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKI-VSEGLVTPTGIAIDWYT 75
L+ A+D N I W D I ++ ++ ++ + E L +P G+A+DW
Sbjct: 279 LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVH 338
Query: 76 DKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERA 135
+YWTD I V ++ R+ LF + RAIAV P G M+W+DWG+ KIE++
Sbjct: 339 KHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKS 398
Query: 136 GMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVKGG- 194
G+NG R+ +V DNI WPNGIT+D + +YWVD+KL + IDF+G RK ++
Sbjct: 399 GLNG--VDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTD 456
Query: 195 -LVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESRQII 253
L +PF + DK++WTD +N +I++ + NG +I L ++ P DI ++ E +Q
Sbjct: 457 FLSHPFGIAVFEDKVFWTDLENEAIFSAN-RLNGLEISILAENLNNPHDIVIFHELKQPR 515
Query: 254 SAEDYPCK-KNNAGCSHLCLLSPD----PPGYNCACPTGVKLRENSSTTCYDSPQMLLVV 308
+ + + N GC +LCL +P P Y CACP + L + CY +PQ
Sbjct: 516 APDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMK-RCYRAPQSTSTT 574
Query: 309 AQRSTISK 316
ST+++
Sbjct: 575 TLASTMTR 582
Score = 163 bits (397), Expect = 3e-39
Identities = 111/365 (30%), Positives = 175/365 (47%), Gaps = 31/365 (8%)
Query: 260 CKKNNAGCSHLCLLSPDPPGY-NCACPTGVK---LRENSSTTCYDSPQMLLVVAQRSTIS 315
CK +A CS +C+ + GY C C G + L +N SP L+ R +
Sbjct: 210 CKDPDA-CSQICV---NYKGYFKCECYPGYEMDLLTKNCKAAGGKSPS--LIFTNRYEVR 263
Query: 316 KISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGS----DQSV 371
+I L +++ +P+ LK + +D + T IYW D + I A +D + +Q V
Sbjct: 264 RIDLVKRNYSRL-IPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEV 320
Query: 372 VVRSS-GVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLT 430
++ P+ +A+D + + IYWTD TI+VA +DG + + L +PRAIA+
Sbjct: 321 LIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPL 380
Query: 431 AGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIE 490
G+M+WSDW + + KIE++ L+G R L+S+ + WPN I LD ++ +LYW D++ H++
Sbjct: 381 RGFMYWSDWGD-QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS 439
Query: 491 VCNMDGTERKEL-HSNDII-HIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQM 548
+ G RK L S D + H FG ++ + N+ GL+ + E +
Sbjct: 440 SIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL 499
Query: 549 ANMMGVKAF-RLGAPLGWNPC---ADDNGGCSHLCFNRPD------DYICGCPLGLELTA 598
N + F L P + C NGGC +LC P Y C CP + L
Sbjct: 500 NNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGP 559
Query: 599 DKKTC 603
D K C
Sbjct: 560 DMKRC 564
Score = 161 bits (391), Expect = 1e-38
Identities = 99/355 (27%), Positives = 173/355 (48%), Gaps = 21/355 (5%)
Query: 571 DNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEP---EAFLVYSRKNIIGRLSIKNEY 627
D CS +C N + C C G E+ K C L+++ + + R+ +
Sbjct: 212 DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAGGKSPSLIFTNRYEVRRIDLVKRN 271
Query: 628 NDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEK-----IVEWLGLV 682
+IP+ LK V AL + V+ +++YW D + I ++ ++ K I E L
Sbjct: 272 YSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSP 329
Query: 683 EGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
EGLA+DW ++IYWTD+ + I V+ +DG RR + + L +P++I +DP +G+MYWS+
Sbjct: 330 EGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW 389
Query: 743 GSKS-IKRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQ 800
G ++ I+++ ++G ++ + + + + +D + +YW + +G R+
Sbjct: 390 GDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRK 449
Query: 801 TL---ADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYH 857
TL D + P+ +A+F D V+W D I A + +G + ++L+ D+ ++H
Sbjct: 450 TLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFH 509
Query: 858 RAKS-MGSNQCGVD---NGGCSHLCLPTP--GDVRTDYRCACPAHYRLNKDNITC 906
K + C + NGGC +LCLP P Y CACP L D C
Sbjct: 510 ELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 564
Score = 105 bits (253), Expect = 7e-22
Identities = 77/295 (26%), Positives = 138/295 (46%), Gaps = 12/295 (4%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGRLSIKN 625
N C +NGGCSH+C + + C CP G +L D+KTC + + + I ++ K
Sbjct: 168 NECLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGDIDECKDPDACSQI-CVNYKG 225
Query: 626 EYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVEGL 685
+ P ++ ++ G + + R + +++ L V L
Sbjct: 226 YFKCECYPGYEMDLLTKNCKAAGGKSPSLIFTNRYEVRRIDLVKRNYSRLIPMLKNVVAL 285
Query: 686 AIDWSGQNIYWTDTTTQRIEVSRLDGSS----RRAIIWQGLKKPKSIVLDPKKGYMYWSE 741
++ + IYW D + ++I + +D +S + +I + L P+ + +D ++YW++
Sbjct: 286 DVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTD 345
Query: 742 LGSKSIKRAAMDGS-SVSVFMEQVGRVHALAIDYERRAIYWAAL-DPPVVEFAFLNGTGR 799
G+K+I A +DG ++F + A+A+D R +YW+ D +E + LNG R
Sbjct: 346 SGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDR 405
Query: 800 QTL-ADNIPMP--YALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYIS 851
QTL +DNI P L L + +YW D Q+ G NRK++ D++S
Sbjct: 406 QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSI-DFSGGNRKTLISSTDFLS 459
Score = 72.5 bits (170), Expect = 8e-12
Identities = 62/253 (24%), Positives = 109/253 (43%), Gaps = 14/253 (5%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISL 319
C NN GCSH+C + G+ C CP G +L + + D + +Q K
Sbjct: 170 CLHNNGGCSHIC--TDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 227
Query: 320 DSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGVP 379
+ Y + L L + I+ + I + + S ++++
Sbjct: 228 KCECYPGYEMDL--LTKNCKAAGGKSPSLIFTNRYEVRRIDLVKRNYSRLIPMLKNVVAL 285
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLDGS----YEKVIIHTELYDPRAIALHLTAGWMF 435
D ++ + +IYW D I A +D + ++V+I +L+ P +A+ ++
Sbjct: 286 D---VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 342
Query: 436 WSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGD-ARTHKIEVCNM 494
W+D K I A +DG R L S L+ P +IA+D + +YW D KIE +
Sbjct: 343 WTDSGNK--TISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGL 400
Query: 495 DGTERKELHSNDI 507
+G +R+ L S++I
Sbjct: 401 NGVDRQTLVSDNI 413
Score = 54.4 bits (125), Expect = 2e-06
Identities = 53/235 (22%), Positives = 99/235 (42%), Gaps = 21/235 (8%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEP---EEFLLFAQKNAVGRIMV 926
D CS +C+ G ++C C Y ++ C L+F + V RI +
Sbjct: 212 DPDACSQICVNYKGY----FKCECYPGYEMDLLTKNCKAAGGKSPSLIFTNRYEVRRIDL 267
Query: 927 ANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXX--XXXXXX 984
+ IP+ LKNV A++ + ++YW D S R++ +Y
Sbjct: 268 VKRNYS-RLIPM--LKNVVALDVEVATNRIYWCD---LSYRKIYSAYMDKASDPKEQEVL 321
Query: 985 XXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQT 1044
L P + +D + + +YWT + +I+ ++D + R + PR +A
Sbjct: 322 IDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSR-NLSEPRAIAVDPL 380
Query: 1045 KRYLIWNDVG-RGAIMRANVDGTGRVELARADN---ATALALDQSAGTVYWAVSR 1095
+ ++ W+D G + I ++ ++G R L +DN + LD + +YW S+
Sbjct: 381 RGFMYWSDWGDQAKIEKSGLNGVDRQTLV-SDNIEWPNGITLDLLSQRLYWVDSK 434
Score = 52.4 bits (120), Expect = 9e-06
Identities = 58/238 (24%), Positives = 91/238 (38%), Gaps = 28/238 (11%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRI 924
N+C +NGGCSH+C D++ + C CPA ++L D TC + +E +A +I
Sbjct: 168 NECLHNNGGCSHICT----DLKIGFECTCPAGFQL-LDQKTCGDIDE---CKDPDACSQI 219
Query: 925 MV-----ANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXX 979
V EC Y KN +A K + + + +RR+ +
Sbjct: 220 CVNYKGYFKCECYPGYEMDLLTKNCKAAG----GKSPSLIFTNRYEVRRIDLVKRNYSRL 275
Query: 980 XXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNS---STGVIVRGDRMLP 1036
L ++V +YW I + +D S V++ P
Sbjct: 276 IPMLKNVVALD------VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSP 329
Query: 1037 RHLAFHQTKRYLIWNDVGRGAIMRANVDGTGRVEL--ARADNATALALDQSAGTVYWA 1092
LA +++ W D G I A VDG R L A+A+D G +YW+
Sbjct: 330 EGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWS 387
Score = 47.2 bits (107), Expect = 4e-04
Identities = 18/32 (56%), Positives = 21/32 (65%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F CD G CI R+ CDG +C DGSDE+ A C
Sbjct: 91 FTCDNGHCIHERWKCDGEEECPDGSDESEATC 122
Score = 33.1 bits (72), Expect = 6.2
Identities = 12/19 (63%), Positives = 15/19 (78%)
Query: 1094 SRQCDGQQDCEDGRDEAEC 1112
S +CDG++DCE G DEA C
Sbjct: 145 SWRCDGEKDCEGGADEAGC 163
>D86407-1|BAA21824.1| 963|Homo sapiens ApoER2 protein.
Length = 963
Score = 185 bits (451), Expect = 7e-46
Identities = 105/308 (34%), Positives = 164/308 (53%), Gaps = 12/308 (3%)
Query: 17 LEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKI-VSEGLVTPTGIAIDWYT 75
L+ A+D N I W D I ++ ++ ++ + E L +P G+A+DW
Sbjct: 449 LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVH 508
Query: 76 DKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERA 135
+YWTD I V ++ R+ LF + RAIAV P G M+W+DWG+ KIE++
Sbjct: 509 KHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKS 568
Query: 136 GMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVKGG- 194
G+NG R+ +V DNI WPNGIT+D + +YWVD+KL + IDF+G RK ++
Sbjct: 569 GLNG--VDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTD 626
Query: 195 -LVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESRQII 253
L +PF + DK++WTD +N +I++ + NG +I L ++ P DI ++ E +Q
Sbjct: 627 FLSHPFGIAVFEDKVFWTDLENEAIFSAN-RLNGLEISILAENLNNPHDIVIFHELKQPR 685
Query: 254 SAEDYPCK-KNNAGCSHLCLLSPD----PPGYNCACPTGVKLRENSSTTCYDSPQMLLVV 308
+ + + N GC +LCL +P P Y CACP + L + CY +PQ
Sbjct: 686 APDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMK-RCYRAPQSTSTT 744
Query: 309 AQRSTISK 316
ST+++
Sbjct: 745 TLASTMTR 752
Score = 163 bits (397), Expect = 3e-39
Identities = 111/365 (30%), Positives = 175/365 (47%), Gaps = 31/365 (8%)
Query: 260 CKKNNAGCSHLCLLSPDPPGY-NCACPTGVK---LRENSSTTCYDSPQMLLVVAQRSTIS 315
CK +A CS +C+ + GY C C G + L +N SP L+ R +
Sbjct: 380 CKDPDA-CSQICV---NYKGYFKCECYPGYEMDLLTKNCKAAGGKSPS--LIFTNRYEVR 433
Query: 316 KISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGS----DQSV 371
+I L +++ +P+ LK + +D + T IYW D + I A +D + +Q V
Sbjct: 434 RIDLVKRNYSRL-IPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEV 490
Query: 372 VVRSS-GVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLT 430
++ P+ +A+D + + IYWTD TI+VA +DG + + L +PRAIA+
Sbjct: 491 LIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPL 550
Query: 431 AGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIE 490
G+M+WSDW + + KIE++ L+G R L+S+ + WPN I LD ++ +LYW D++ H++
Sbjct: 551 RGFMYWSDWGD-QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS 609
Query: 491 VCNMDGTERKEL-HSNDII-HIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQM 548
+ G RK L S D + H FG ++ + N+ GL+ + E +
Sbjct: 610 SIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL 669
Query: 549 ANMMGVKAF-RLGAPLGWNPC---ADDNGGCSHLCFNRPD------DYICGCPLGLELTA 598
N + F L P + C NGGC +LC P Y C CP + L
Sbjct: 670 NNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGP 729
Query: 599 DKKTC 603
D K C
Sbjct: 730 DMKRC 734
Score = 161 bits (391), Expect = 1e-38
Identities = 99/355 (27%), Positives = 173/355 (48%), Gaps = 21/355 (5%)
Query: 571 DNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEP---EAFLVYSRKNIIGRLSIKNEY 627
D CS +C N + C C G E+ K C L+++ + + R+ +
Sbjct: 382 DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAGGKSPSLIFTNRYEVRRIDLVKRN 441
Query: 628 NDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEK-----IVEWLGLV 682
+IP+ LK V AL + V+ +++YW D + I ++ ++ K I E L
Sbjct: 442 YSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSP 499
Query: 683 EGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
EGLA+DW ++IYWTD+ + I V+ +DG RR + + L +P++I +DP +G+MYWS+
Sbjct: 500 EGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW 559
Query: 743 GSKS-IKRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQ 800
G ++ I+++ ++G ++ + + + + +D + +YW + +G R+
Sbjct: 560 GDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRK 619
Query: 801 TL---ADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYH 857
TL D + P+ +A+F D V+W D I A + +G + ++L+ D+ ++H
Sbjct: 620 TLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFH 679
Query: 858 RAKS-MGSNQCGVD---NGGCSHLCLPTP--GDVRTDYRCACPAHYRLNKDNITC 906
K + C + NGGC +LCLP P Y CACP L D C
Sbjct: 680 ELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
Score = 107 bits (258), Expect = 2e-22
Identities = 79/301 (26%), Positives = 140/301 (46%), Gaps = 12/301 (3%)
Query: 560 GAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIG 619
G G N C +NGGCSH+C + + C CP G +L D+KTC + + + I
Sbjct: 332 GCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGDIDECKDPDACSQI- 389
Query: 620 RLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWL 679
++ K + P ++ ++ G + + R + +++ L
Sbjct: 390 CVNYKGYFKCECYPGYEMDLLTKNCKAAGGKSPSLIFTNRYEVRRIDLVKRNYSRLIPML 449
Query: 680 GLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSS----RRAIIWQGLKKPKSIVLDPKKG 735
V L ++ + IYW D + ++I + +D +S + +I + L P+ + +D
Sbjct: 450 KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHK 509
Query: 736 YMYWSELGSKSIKRAAMDGS-SVSVFMEQVGRVHALAIDYERRAIYWAAL-DPPVVEFAF 793
++YW++ G+K+I A +DG ++F + A+A+D R +YW+ D +E +
Sbjct: 510 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSG 569
Query: 794 LNGTGRQTL-ADNIPMP--YALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYI 850
LNG RQTL +DNI P L L + +YW D Q+ G NRK++ D++
Sbjct: 570 LNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSI-DFSGGNRKTLISSTDFL 628
Query: 851 S 851
S
Sbjct: 629 S 629
Score = 72.5 bits (170), Expect = 8e-12
Identities = 62/253 (24%), Positives = 109/253 (43%), Gaps = 14/253 (5%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISL 319
C NN GCSH+C + G+ C CP G +L + + D + +Q K
Sbjct: 340 CLHNNGGCSHIC--TDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 397
Query: 320 DSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGVP 379
+ Y + L L + I+ + I + + S ++++
Sbjct: 398 KCECYPGYEMDL--LTKNCKAAGGKSPSLIFTNRYEVRRIDLVKRNYSRLIPMLKNVVAL 455
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLDGS----YEKVIIHTELYDPRAIALHLTAGWMF 435
D ++ + +IYW D I A +D + ++V+I +L+ P +A+ ++
Sbjct: 456 D---VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
Query: 436 WSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGD-ARTHKIEVCNM 494
W+D K I A +DG R L S L+ P +IA+D + +YW D KIE +
Sbjct: 513 WTDSGNK--TISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGL 570
Query: 495 DGTERKELHSNDI 507
+G +R+ L S++I
Sbjct: 571 NGVDRQTLVSDNI 583
Score = 54.4 bits (125), Expect = 2e-06
Identities = 53/235 (22%), Positives = 99/235 (42%), Gaps = 21/235 (8%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEP---EEFLLFAQKNAVGRIMV 926
D CS +C+ G ++C C Y ++ C L+F + V RI +
Sbjct: 382 DPDACSQICVNYKGY----FKCECYPGYEMDLLTKNCKAAGGKSPSLIFTNRYEVRRIDL 437
Query: 927 ANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXX--XXXXXX 984
+ IP+ LKNV A++ + ++YW D S R++ +Y
Sbjct: 438 VKRNYS-RLIPM--LKNVVALDVEVATNRIYWCD---LSYRKIYSAYMDKASDPKEQEVL 491
Query: 985 XXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQT 1044
L P + +D + + +YWT + +I+ ++D + R + PR +A
Sbjct: 492 IDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSR-NLSEPRAIAVDPL 550
Query: 1045 KRYLIWNDVG-RGAIMRANVDGTGRVELARADN---ATALALDQSAGTVYWAVSR 1095
+ ++ W+D G + I ++ ++G R L +DN + LD + +YW S+
Sbjct: 551 RGFMYWSDWGDQAKIEKSGLNGVDRQTLV-SDNIEWPNGITLDLLSQRLYWVDSK 604
Score = 54.0 bits (124), Expect = 3e-06
Identities = 59/240 (24%), Positives = 92/240 (38%), Gaps = 28/240 (11%)
Query: 863 GSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVG 922
G N+C +NGGCSH+C D++ + C CPA ++L D TC + +E +A
Sbjct: 336 GLNECLHNNGGCSHICT----DLKIGFECTCPAGFQL-LDQKTCGDIDE---CKDPDACS 387
Query: 923 RIMV-----ANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXX 977
+I V EC Y KN +A K + + + +RR+ +
Sbjct: 388 QICVNYKGYFKCECYPGYEMDLLTKNCKAAG----GKSPSLIFTNRYEVRRIDLVKRNYS 443
Query: 978 XXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNS---STGVIVRGDRM 1034
L ++V +YW I + +D S V++
Sbjct: 444 RLIPMLKNVVALD------VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH 497
Query: 1035 LPRHLAFHQTKRYLIWNDVGRGAIMRANVDGTGRVEL--ARADNATALALDQSAGTVYWA 1092
P LA +++ W D G I A VDG R L A+A+D G +YW+
Sbjct: 498 SPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWS 557
Score = 47.2 bits (107), Expect = 4e-04
Identities = 18/32 (56%), Positives = 21/32 (65%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F CD G CI R+ CDG +C DGSDE+ A C
Sbjct: 91 FTCDNGHCIHERWKCDGEEECPDGSDESEATC 122
Score = 44.0 bits (99), Expect = 0.003
Identities = 31/99 (31%), Positives = 40/99 (40%), Gaps = 16/99 (16%)
Query: 1096 QCDGQQDCEDGRDEAE-------CGA----CGGDV-RCADGT----XXXXXXXXXXXXXX 1139
+CDG+++C DG DE+E C A CG +C +
Sbjct: 104 KCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
Query: 1140 XXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAA 1178
F+C C+AA FVCDG C DGSDE A
Sbjct: 164 ATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCA 202
Score = 43.2 bits (97), Expect = 0.006
Identities = 34/102 (33%), Positives = 42/102 (41%), Gaps = 17/102 (16%)
Query: 1094 SRQCDGQQDCEDGRDEA-----------ECG--ACGGDVRCADGTXXXXXXXXXXXXXXX 1140
S +CDG++DCE G DEA +CG +C V DG
Sbjct: 145 SWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADP 204
Query: 1141 XXXXXDAFRCDE---GLCIAARFVCDGRPQCADGSDEAPAAC 1179
+ FRC G CI R+VCD + C D SDEA C
Sbjct: 205 ACGPRE-FRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELC 245
Score = 42.3 bits (95), Expect = 0.010
Identities = 18/33 (54%), Positives = 23/33 (69%), Gaps = 3/33 (9%)
Query: 1096 QCDGQQDCEDGRDEAEC--GACGGD-VRCADGT 1125
+CDG +DC+D DEA+C G C GD +C DGT
Sbjct: 278 RCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGT 310
Score = 35.9 bits (79), Expect = 0.87
Identities = 14/30 (46%), Positives = 18/30 (60%)
Query: 1146 DAFRCDEGLCIAARFVCDGRPQCADGSDEA 1175
D F+C +G C+ A C+ C DGSDEA
Sbjct: 302 DEFQCGDGTCVLAIKHCNQEQDCPDGSDEA 331
>D50678-1|BAA09328.1| 963|Homo sapiens apolipoprotein E receptor 2
precursor protein.
Length = 963
Score = 185 bits (451), Expect = 7e-46
Identities = 105/308 (34%), Positives = 164/308 (53%), Gaps = 12/308 (3%)
Query: 17 LEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKI-VSEGLVTPTGIAIDWYT 75
L+ A+D N I W D I ++ ++ ++ + E L +P G+A+DW
Sbjct: 449 LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVH 508
Query: 76 DKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERA 135
+YWTD I V ++ R+ LF + RAIAV P G M+W+DWG+ KIE++
Sbjct: 509 KHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKS 568
Query: 136 GMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVKGG- 194
G+NG R+ +V DNI WPNGIT+D + +YWVD+KL + IDF+G RK ++
Sbjct: 569 GLNG--VDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTD 626
Query: 195 -LVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESRQII 253
L +PF + DK++WTD +N +I++ + NG +I L ++ P DI ++ E +Q
Sbjct: 627 FLSHPFGIAVFEDKVFWTDLENEAIFSAN-RLNGLEISILAENLNNPHDIVIFHELKQPR 685
Query: 254 SAEDYPCK-KNNAGCSHLCLLSPD----PPGYNCACPTGVKLRENSSTTCYDSPQMLLVV 308
+ + + N GC +LCL +P P Y CACP + L + CY +PQ
Sbjct: 686 APDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMK-RCYRAPQSTSTT 744
Query: 309 AQRSTISK 316
ST+++
Sbjct: 745 TLASTMTR 752
Score = 163 bits (397), Expect = 3e-39
Identities = 111/365 (30%), Positives = 175/365 (47%), Gaps = 31/365 (8%)
Query: 260 CKKNNAGCSHLCLLSPDPPGY-NCACPTGVK---LRENSSTTCYDSPQMLLVVAQRSTIS 315
CK +A CS +C+ + GY C C G + L +N SP L+ R +
Sbjct: 380 CKDPDA-CSQICV---NYKGYFKCECYPGYEMDLLTKNCKAAGGKSPS--LIFTNRYEVR 433
Query: 316 KISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGS----DQSV 371
+I L +++ +P+ LK + +D + T IYW D + I A +D + +Q V
Sbjct: 434 RIDLVKRNYSRL-IPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEV 490
Query: 372 VVRSS-GVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLT 430
++ P+ +A+D + + IYWTD TI+VA +DG + + L +PRAIA+
Sbjct: 491 LIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPL 550
Query: 431 AGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIE 490
G+M+WSDW + + KIE++ L+G R L+S+ + WPN I LD ++ +LYW D++ H++
Sbjct: 551 RGFMYWSDWGD-QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS 609
Query: 491 VCNMDGTERKEL-HSNDII-HIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQM 548
+ G RK L S D + H FG ++ + N+ GL+ + E +
Sbjct: 610 SIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL 669
Query: 549 ANMMGVKAF-RLGAPLGWNPC---ADDNGGCSHLCFNRPD------DYICGCPLGLELTA 598
N + F L P + C NGGC +LC P Y C CP + L
Sbjct: 670 NNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGP 729
Query: 599 DKKTC 603
D K C
Sbjct: 730 DMKRC 734
Score = 161 bits (391), Expect = 1e-38
Identities = 99/355 (27%), Positives = 173/355 (48%), Gaps = 21/355 (5%)
Query: 571 DNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEP---EAFLVYSRKNIIGRLSIKNEY 627
D CS +C N + C C G E+ K C L+++ + + R+ +
Sbjct: 382 DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAGGKSPSLIFTNRYEVRRIDLVKRN 441
Query: 628 NDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEK-----IVEWLGLV 682
+IP+ LK V AL + V+ +++YW D + I ++ ++ K I E L
Sbjct: 442 YSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSP 499
Query: 683 EGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
EGLA+DW ++IYWTD+ + I V+ +DG RR + + L +P++I +DP +G+MYWS+
Sbjct: 500 EGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW 559
Query: 743 GSKS-IKRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQ 800
G ++ I+++ ++G ++ + + + + +D + +YW + +G R+
Sbjct: 560 GDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRK 619
Query: 801 TL---ADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYH 857
TL D + P+ +A+F D V+W D I A + +G + ++L+ D+ ++H
Sbjct: 620 TLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFH 679
Query: 858 RAKS-MGSNQCGVD---NGGCSHLCLPTP--GDVRTDYRCACPAHYRLNKDNITC 906
K + C + NGGC +LCLP P Y CACP L D C
Sbjct: 680 ELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
Score = 107 bits (258), Expect = 2e-22
Identities = 79/301 (26%), Positives = 140/301 (46%), Gaps = 12/301 (3%)
Query: 560 GAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIG 619
G G N C +NGGCSH+C + + C CP G +L D+KTC + + + I
Sbjct: 332 GCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGDIDECKDPDACSQI- 389
Query: 620 RLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWL 679
++ K + P ++ ++ G + + R + +++ L
Sbjct: 390 CVNYKGYFKCECYPGYEMDLLTKNCKAAGGKSPSLIFTNRYEVRRIDLVKRNYSRLIPML 449
Query: 680 GLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSS----RRAIIWQGLKKPKSIVLDPKKG 735
V L ++ + IYW D + ++I + +D +S + +I + L P+ + +D
Sbjct: 450 KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHK 509
Query: 736 YMYWSELGSKSIKRAAMDGS-SVSVFMEQVGRVHALAIDYERRAIYWAAL-DPPVVEFAF 793
++YW++ G+K+I A +DG ++F + A+A+D R +YW+ D +E +
Sbjct: 510 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSG 569
Query: 794 LNGTGRQTL-ADNIPMP--YALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYI 850
LNG RQTL +DNI P L L + +YW D Q+ G NRK++ D++
Sbjct: 570 LNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSI-DFSGGNRKTLISSTDFL 628
Query: 851 S 851
S
Sbjct: 629 S 629
Score = 72.5 bits (170), Expect = 8e-12
Identities = 62/253 (24%), Positives = 109/253 (43%), Gaps = 14/253 (5%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISL 319
C NN GCSH+C + G+ C CP G +L + + D + +Q K
Sbjct: 340 CLHNNGGCSHIC--TDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 397
Query: 320 DSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGVP 379
+ Y + L L + I+ + I + + S ++++
Sbjct: 398 KCECYPGYEMDL--LTKNCKAAGGKSPSLIFTNRYEVRRIDLVKRNYSRLIPMLKNVVAL 455
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLDGS----YEKVIIHTELYDPRAIALHLTAGWMF 435
D ++ + +IYW D I A +D + ++V+I +L+ P +A+ ++
Sbjct: 456 D---VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
Query: 436 WSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGD-ARTHKIEVCNM 494
W+D K I A +DG R L S L+ P +IA+D + +YW D KIE +
Sbjct: 513 WTDSGNK--TISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGL 570
Query: 495 DGTERKELHSNDI 507
+G +R+ L S++I
Sbjct: 571 NGVDRQTLVSDNI 583
Score = 54.4 bits (125), Expect = 2e-06
Identities = 53/235 (22%), Positives = 99/235 (42%), Gaps = 21/235 (8%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEP---EEFLLFAQKNAVGRIMV 926
D CS +C+ G ++C C Y ++ C L+F + V RI +
Sbjct: 382 DPDACSQICVNYKGY----FKCECYPGYEMDLLTKNCKAAGGKSPSLIFTNRYEVRRIDL 437
Query: 927 ANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXX--XXXXXX 984
+ IP+ LKNV A++ + ++YW D S R++ +Y
Sbjct: 438 VKRNYS-RLIPM--LKNVVALDVEVATNRIYWCD---LSYRKIYSAYMDKASDPKEQEVL 491
Query: 985 XXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQT 1044
L P + +D + + +YWT + +I+ ++D + R + PR +A
Sbjct: 492 IDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSR-NLSEPRAIAVDPL 550
Query: 1045 KRYLIWNDVG-RGAIMRANVDGTGRVELARADN---ATALALDQSAGTVYWAVSR 1095
+ ++ W+D G + I ++ ++G R L +DN + LD + +YW S+
Sbjct: 551 RGFMYWSDWGDQAKIEKSGLNGVDRQTLV-SDNIEWPNGITLDLLSQRLYWVDSK 604
Score = 54.0 bits (124), Expect = 3e-06
Identities = 59/240 (24%), Positives = 92/240 (38%), Gaps = 28/240 (11%)
Query: 863 GSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVG 922
G N+C +NGGCSH+C D++ + C CPA ++L D TC + +E +A
Sbjct: 336 GLNECLHNNGGCSHICT----DLKIGFECTCPAGFQL-LDQKTCGDIDE---CKDPDACS 387
Query: 923 RIMV-----ANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXX 977
+I V EC Y KN +A K + + + +RR+ +
Sbjct: 388 QICVNYKGYFKCECYPGYEMDLLTKNCKAAG----GKSPSLIFTNRYEVRRIDLVKRNYS 443
Query: 978 XXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNS---STGVIVRGDRM 1034
L ++V +YW I + +D S V++
Sbjct: 444 RLIPMLKNVVALD------VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH 497
Query: 1035 LPRHLAFHQTKRYLIWNDVGRGAIMRANVDGTGRVEL--ARADNATALALDQSAGTVYWA 1092
P LA +++ W D G I A VDG R L A+A+D G +YW+
Sbjct: 498 SPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWS 557
Score = 47.2 bits (107), Expect = 4e-04
Identities = 18/32 (56%), Positives = 21/32 (65%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F CD G CI R+ CDG +C DGSDE+ A C
Sbjct: 91 FTCDNGHCIHERWKCDGEEECPDGSDESEATC 122
Score = 44.0 bits (99), Expect = 0.003
Identities = 31/99 (31%), Positives = 40/99 (40%), Gaps = 16/99 (16%)
Query: 1096 QCDGQQDCEDGRDEAE-------CGA----CGGDV-RCADGT----XXXXXXXXXXXXXX 1139
+CDG+++C DG DE+E C A CG +C +
Sbjct: 104 KCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
Query: 1140 XXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAA 1178
F+C C+AA FVCDG C DGSDE A
Sbjct: 164 ATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCA 202
Score = 43.2 bits (97), Expect = 0.006
Identities = 34/102 (33%), Positives = 42/102 (41%), Gaps = 17/102 (16%)
Query: 1094 SRQCDGQQDCEDGRDEA-----------ECG--ACGGDVRCADGTXXXXXXXXXXXXXXX 1140
S +CDG++DCE G DEA +CG +C V DG
Sbjct: 145 SWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADP 204
Query: 1141 XXXXXDAFRCDE---GLCIAARFVCDGRPQCADGSDEAPAAC 1179
+ FRC G CI R+VCD + C D SDEA C
Sbjct: 205 ACGPRE-FRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELC 245
Score = 42.3 bits (95), Expect = 0.010
Identities = 18/33 (54%), Positives = 23/33 (69%), Gaps = 3/33 (9%)
Query: 1096 QCDGQQDCEDGRDEAEC--GACGGD-VRCADGT 1125
+CDG +DC+D DEA+C G C GD +C DGT
Sbjct: 278 RCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGT 310
Score = 35.9 bits (79), Expect = 0.87
Identities = 14/30 (46%), Positives = 18/30 (60%)
Query: 1146 DAFRCDEGLCIAARFVCDGRPQCADGSDEA 1175
D F+C +G C+ A C+ C DGSDEA
Sbjct: 302 DEFQCGDGTCVLAIKHCNQEQDCPDGSDEA 331
>BC051836-1|AAH51836.2| 904|Homo sapiens low density lipoprotein
receptor-related protein 8, apolipoprotein e receptor
protein.
Length = 904
Score = 185 bits (451), Expect = 7e-46
Identities = 105/308 (34%), Positives = 164/308 (53%), Gaps = 12/308 (3%)
Query: 17 LEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKI-VSEGLVTPTGIAIDWYT 75
L+ A+D N I W D I ++ ++ ++ + E L +P G+A+DW
Sbjct: 449 LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVH 508
Query: 76 DKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERA 135
+YWTD I V ++ R+ LF + RAIAV P G M+W+DWG+ KIE++
Sbjct: 509 KHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKS 568
Query: 136 GMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVKGG- 194
G+NG R+ +V DNI WPNGIT+D + +YWVD+KL + IDF+G RK ++
Sbjct: 569 GLNG--VDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTD 626
Query: 195 -LVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESRQII 253
L +PF + DK++WTD +N +I++ + NG +I L ++ P DI ++ E +Q
Sbjct: 627 FLSHPFGIAVFEDKVFWTDLENEAIFSAN-RLNGLEISILAENLNNPHDIVIFHELKQPR 685
Query: 254 SAEDYPCK-KNNAGCSHLCLLSPD----PPGYNCACPTGVKLRENSSTTCYDSPQMLLVV 308
+ + + N GC +LCL +P P Y CACP + L + CY +PQ
Sbjct: 686 APDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMK-RCYRAPQSTSTT 744
Query: 309 AQRSTISK 316
ST+++
Sbjct: 745 TLASTMTR 752
Score = 165 bits (401), Expect = 8e-40
Identities = 111/365 (30%), Positives = 175/365 (47%), Gaps = 31/365 (8%)
Query: 260 CKKNNAGCSHLCLLSPDPPGY-NCACPTGVK---LRENSSTTCYDSPQMLLVVAQRSTIS 315
CK +A CS +C+ + GY C C G + L +N SP L+ R +
Sbjct: 380 CKDPDA-CSQICV---NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPS--LIFTNRHEVR 433
Query: 316 KISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGS----DQSV 371
+I L +++ +P+ LK + +D + T IYW D + I A +D + +Q V
Sbjct: 434 RIDLVKRNYSRL-IPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEV 490
Query: 372 VVRSS-GVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLT 430
++ P+ +A+D + + IYWTD TI+VA +DG + + L +PRAIA+
Sbjct: 491 LIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPL 550
Query: 431 AGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIE 490
G+M+WSDW + + KIE++ L+G R L+S+ + WPN I LD ++ +LYW D++ H++
Sbjct: 551 RGFMYWSDWGD-QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS 609
Query: 491 VCNMDGTERKEL-HSNDII-HIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQM 548
+ G RK L S D + H FG ++ + N+ GL+ + E +
Sbjct: 610 SIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL 669
Query: 549 ANMMGVKAF-RLGAPLGWNPC---ADDNGGCSHLCFNRPD------DYICGCPLGLELTA 598
N + F L P + C NGGC +LC P Y C CP + L
Sbjct: 670 NNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGP 729
Query: 599 DKKTC 603
D K C
Sbjct: 730 DMKRC 734
Score = 163 bits (397), Expect = 3e-39
Identities = 100/355 (28%), Positives = 175/355 (49%), Gaps = 21/355 (5%)
Query: 571 DNGGCSHLCFNRPDDYICGCPLGLE---LTADKKTCVEPEAFLVYSRKNIIGRLSIKNEY 627
D CS +C N + C C G E LT + K L+++ ++ + R+ +
Sbjct: 382 DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRN 441
Query: 628 NDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEK-----IVEWLGLV 682
+IP+ LK V AL + V+ +++YW D + I ++ ++ K I E L
Sbjct: 442 YSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSP 499
Query: 683 EGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
EGLA+DW ++IYWTD+ + I V+ +DG RR + + L +P++I +DP +G+MYWS+
Sbjct: 500 EGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW 559
Query: 743 GSKS-IKRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQ 800
G ++ I+++ ++G ++ + + + + +D + +YW + +G R+
Sbjct: 560 GDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRK 619
Query: 801 TL---ADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYH 857
TL D + P+ +A+F D V+W D I A + +G + ++L+ D+ ++H
Sbjct: 620 TLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFH 679
Query: 858 RAKS-MGSNQCGVD---NGGCSHLCLPTP--GDVRTDYRCACPAHYRLNKDNITC 906
K + C + NGGC +LCLP P Y CACP L D C
Sbjct: 680 ELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
Score = 108 bits (260), Expect = 1e-22
Identities = 79/301 (26%), Positives = 141/301 (46%), Gaps = 12/301 (3%)
Query: 560 GAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIG 619
G G N C +NGGCSH+C + + C CP G +L D+KTC + + + I
Sbjct: 332 GCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGDIDECKDPDACSQI- 389
Query: 620 RLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWL 679
++ K + P ++ ++ +G + + R + +++ L
Sbjct: 390 CVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPML 449
Query: 680 GLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSS----RRAIIWQGLKKPKSIVLDPKKG 735
V L ++ + IYW D + ++I + +D +S + +I + L P+ + +D
Sbjct: 450 KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHK 509
Query: 736 YMYWSELGSKSIKRAAMDGS-SVSVFMEQVGRVHALAIDYERRAIYWAAL-DPPVVEFAF 793
++YW++ G+K+I A +DG ++F + A+A+D R +YW+ D +E +
Sbjct: 510 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSG 569
Query: 794 LNGTGRQTL-ADNIPMP--YALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYI 850
LNG RQTL +DNI P L L + +YW D Q+ G NRK++ D++
Sbjct: 570 LNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSI-DFSGGNRKTLISSTDFL 628
Query: 851 S 851
S
Sbjct: 629 S 629
Score = 73.3 bits (172), Expect = 5e-12
Identities = 62/253 (24%), Positives = 109/253 (43%), Gaps = 14/253 (5%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISL 319
C NN GCSH+C + G+ C CP G +L + + D + +Q K
Sbjct: 340 CLHNNGGCSHIC--TDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 397
Query: 320 DSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGVP 379
+ Y + L L + I+ + I + + S ++++
Sbjct: 398 KCECYPGYEMDL--LTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVAL 455
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLDGS----YEKVIIHTELYDPRAIALHLTAGWMF 435
D ++ + +IYW D I A +D + ++V+I +L+ P +A+ ++
Sbjct: 456 D---VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
Query: 436 WSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGD-ARTHKIEVCNM 494
W+D K I A +DG R L S L+ P +IA+D + +YW D KIE +
Sbjct: 513 WTDSGNK--TISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGL 570
Query: 495 DGTERKELHSNDI 507
+G +R+ L S++I
Sbjct: 571 NGVDRQTLVSDNI 583
Score = 57.2 bits (132), Expect = 3e-07
Identities = 60/240 (25%), Positives = 92/240 (38%), Gaps = 28/240 (11%)
Query: 863 GSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVG 922
G N+C +NGGCSH+C D++ + C CPA ++L D TC + +E +A
Sbjct: 336 GLNECLHNNGGCSHICT----DLKIGFECTCPAGFQL-LDQKTCGDIDE---CKDPDACS 387
Query: 923 RIMV-----ANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXX 977
+I V EC Y KN +A K + + H +RR+ +
Sbjct: 388 QICVNYKGYFKCECYPGYEMDLLTKNCKA----AAGKSPSLIFTNRHEVRRIDLVKRNYS 443
Query: 978 XXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNS---STGVIVRGDRM 1034
L ++V +YW I + +D S V++
Sbjct: 444 RLIPMLKNVVALD------VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH 497
Query: 1035 LPRHLAFHQTKRYLIWNDVGRGAIMRANVDGTGRVEL--ARADNATALALDQSAGTVYWA 1092
P LA +++ W D G I A VDG R L A+A+D G +YW+
Sbjct: 498 SPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWS 557
Score = 56.0 bits (129), Expect = 8e-07
Identities = 54/235 (22%), Positives = 101/235 (42%), Gaps = 21/235 (8%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYR---LNKDNITCSEPEEFLLFAQKNAVGRIMV 926
D CS +C+ G ++C C Y L K+ + L+F ++ V RI +
Sbjct: 382 DPDACSQICVNYKGY----FKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDL 437
Query: 927 ANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXX--XXXXXX 984
+ IP+ LKNV A++ + ++YW D S R++ +Y
Sbjct: 438 VKRNYS-RLIPM--LKNVVALDVEVATNRIYWCD---LSYRKIYSAYMDKASDPKEQEVL 491
Query: 985 XXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQT 1044
L P + +D + + +YWT + +I+ ++D + R + PR +A
Sbjct: 492 IDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSR-NLSEPRAIAVDPL 550
Query: 1045 KRYLIWNDVG-RGAIMRANVDGTGRVELARADN---ATALALDQSAGTVYWAVSR 1095
+ ++ W+D G + I ++ ++G R L +DN + LD + +YW S+
Sbjct: 551 RGFMYWSDWGDQAKIEKSGLNGVDRQTLV-SDNIEWPNGITLDLLSQRLYWVDSK 604
Score = 47.2 bits (107), Expect = 4e-04
Identities = 18/32 (56%), Positives = 21/32 (65%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F CD G CI R+ CDG +C DGSDE+ A C
Sbjct: 91 FTCDNGHCIHERWKCDGEEECPDGSDESEATC 122
Score = 44.0 bits (99), Expect = 0.003
Identities = 31/99 (31%), Positives = 40/99 (40%), Gaps = 16/99 (16%)
Query: 1096 QCDGQQDCEDGRDEAE-------CGA----CGGDV-RCADGT----XXXXXXXXXXXXXX 1139
+CDG+++C DG DE+E C A CG +C +
Sbjct: 104 KCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
Query: 1140 XXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAA 1178
F+C C+AA FVCDG C DGSDE A
Sbjct: 164 ATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCA 202
Score = 43.2 bits (97), Expect = 0.006
Identities = 34/102 (33%), Positives = 42/102 (41%), Gaps = 17/102 (16%)
Query: 1094 SRQCDGQQDCEDGRDEA-----------ECG--ACGGDVRCADGTXXXXXXXXXXXXXXX 1140
S +CDG++DCE G DEA +CG +C V DG
Sbjct: 145 SWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADP 204
Query: 1141 XXXXXDAFRCDE---GLCIAARFVCDGRPQCADGSDEAPAAC 1179
+ FRC G CI R+VCD + C D SDEA C
Sbjct: 205 ACGPRE-FRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELC 245
Score = 42.3 bits (95), Expect = 0.010
Identities = 18/33 (54%), Positives = 23/33 (69%), Gaps = 3/33 (9%)
Query: 1096 QCDGQQDCEDGRDEAEC--GACGGD-VRCADGT 1125
+CDG +DC+D DEA+C G C GD +C DGT
Sbjct: 278 RCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGT 310
Score = 35.9 bits (79), Expect = 0.87
Identities = 14/30 (46%), Positives = 18/30 (60%)
Query: 1146 DAFRCDEGLCIAARFVCDGRPQCADGSDEA 1175
D F+C +G C+ A C+ C DGSDEA
Sbjct: 302 DEFQCGDGTCVLAIKHCNQEQDCPDGSDEA 331
>AL606760-4|CAI18908.1| 963|Homo sapiens low density lipoprotein
receptor-related protein 8, apolipoprotein e receptor
protein.
Length = 963
Score = 185 bits (451), Expect = 7e-46
Identities = 105/308 (34%), Positives = 164/308 (53%), Gaps = 12/308 (3%)
Query: 17 LEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKI-VSEGLVTPTGIAIDWYT 75
L+ A+D N I W D I ++ ++ ++ + E L +P G+A+DW
Sbjct: 449 LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVH 508
Query: 76 DKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERA 135
+YWTD I V ++ R+ LF + RAIAV P G M+W+DWG+ KIE++
Sbjct: 509 KHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKS 568
Query: 136 GMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVKGG- 194
G+NG R+ +V DNI WPNGIT+D + +YWVD+KL + IDF+G RK ++
Sbjct: 569 GLNG--VDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTD 626
Query: 195 -LVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESRQII 253
L +PF + DK++WTD +N +I++ + NG +I L ++ P DI ++ E +Q
Sbjct: 627 FLSHPFGIAVFEDKVFWTDLENEAIFSAN-RLNGLEISILAENLNNPHDIVIFHELKQPR 685
Query: 254 SAEDYPCK-KNNAGCSHLCLLSPD----PPGYNCACPTGVKLRENSSTTCYDSPQMLLVV 308
+ + + N GC +LCL +P P Y CACP + L + CY +PQ
Sbjct: 686 APDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMK-RCYRAPQSTSTT 744
Query: 309 AQRSTISK 316
ST+++
Sbjct: 745 TLASTMTR 752
Score = 165 bits (401), Expect = 8e-40
Identities = 111/365 (30%), Positives = 175/365 (47%), Gaps = 31/365 (8%)
Query: 260 CKKNNAGCSHLCLLSPDPPGY-NCACPTGVK---LRENSSTTCYDSPQMLLVVAQRSTIS 315
CK +A CS +C+ + GY C C G + L +N SP L+ R +
Sbjct: 380 CKDPDA-CSQICV---NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPS--LIFTNRHEVR 433
Query: 316 KISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGS----DQSV 371
+I L +++ +P+ LK + +D + T IYW D + I A +D + +Q V
Sbjct: 434 RIDLVKRNYSRL-IPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEV 490
Query: 372 VVRSS-GVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLT 430
++ P+ +A+D + + IYWTD TI+VA +DG + + L +PRAIA+
Sbjct: 491 LIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPL 550
Query: 431 AGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIE 490
G+M+WSDW + + KIE++ L+G R L+S+ + WPN I LD ++ +LYW D++ H++
Sbjct: 551 RGFMYWSDWGD-QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS 609
Query: 491 VCNMDGTERKEL-HSNDII-HIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQM 548
+ G RK L S D + H FG ++ + N+ GL+ + E +
Sbjct: 610 SIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL 669
Query: 549 ANMMGVKAF-RLGAPLGWNPC---ADDNGGCSHLCFNRPD------DYICGCPLGLELTA 598
N + F L P + C NGGC +LC P Y C CP + L
Sbjct: 670 NNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGP 729
Query: 599 DKKTC 603
D K C
Sbjct: 730 DMKRC 734
Score = 163 bits (397), Expect = 3e-39
Identities = 100/355 (28%), Positives = 175/355 (49%), Gaps = 21/355 (5%)
Query: 571 DNGGCSHLCFNRPDDYICGCPLGLE---LTADKKTCVEPEAFLVYSRKNIIGRLSIKNEY 627
D CS +C N + C C G E LT + K L+++ ++ + R+ +
Sbjct: 382 DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRN 441
Query: 628 NDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEK-----IVEWLGLV 682
+IP+ LK V AL + V+ +++YW D + I ++ ++ K I E L
Sbjct: 442 YSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSP 499
Query: 683 EGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
EGLA+DW ++IYWTD+ + I V+ +DG RR + + L +P++I +DP +G+MYWS+
Sbjct: 500 EGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW 559
Query: 743 GSKS-IKRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQ 800
G ++ I+++ ++G ++ + + + + +D + +YW + +G R+
Sbjct: 560 GDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRK 619
Query: 801 TL---ADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYH 857
TL D + P+ +A+F D V+W D I A + +G + ++L+ D+ ++H
Sbjct: 620 TLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFH 679
Query: 858 RAKS-MGSNQCGVD---NGGCSHLCLPTP--GDVRTDYRCACPAHYRLNKDNITC 906
K + C + NGGC +LCLP P Y CACP L D C
Sbjct: 680 ELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
Score = 108 bits (260), Expect = 1e-22
Identities = 79/301 (26%), Positives = 141/301 (46%), Gaps = 12/301 (3%)
Query: 560 GAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIG 619
G G N C +NGGCSH+C + + C CP G +L D+KTC + + + I
Sbjct: 332 GCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGDIDECKDPDACSQI- 389
Query: 620 RLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWL 679
++ K + P ++ ++ +G + + R + +++ L
Sbjct: 390 CVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPML 449
Query: 680 GLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSS----RRAIIWQGLKKPKSIVLDPKKG 735
V L ++ + IYW D + ++I + +D +S + +I + L P+ + +D
Sbjct: 450 KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHK 509
Query: 736 YMYWSELGSKSIKRAAMDGS-SVSVFMEQVGRVHALAIDYERRAIYWAAL-DPPVVEFAF 793
++YW++ G+K+I A +DG ++F + A+A+D R +YW+ D +E +
Sbjct: 510 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSG 569
Query: 794 LNGTGRQTL-ADNIPMP--YALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYI 850
LNG RQTL +DNI P L L + +YW D Q+ G NRK++ D++
Sbjct: 570 LNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSI-DFSGGNRKTLISSTDFL 628
Query: 851 S 851
S
Sbjct: 629 S 629
Score = 73.3 bits (172), Expect = 5e-12
Identities = 62/253 (24%), Positives = 109/253 (43%), Gaps = 14/253 (5%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISL 319
C NN GCSH+C + G+ C CP G +L + + D + +Q K
Sbjct: 340 CLHNNGGCSHIC--TDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 397
Query: 320 DSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGVP 379
+ Y + L L + I+ + I + + S ++++
Sbjct: 398 KCECYPGYEMDL--LTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVAL 455
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLDGS----YEKVIIHTELYDPRAIALHLTAGWMF 435
D ++ + +IYW D I A +D + ++V+I +L+ P +A+ ++
Sbjct: 456 D---VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
Query: 436 WSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGD-ARTHKIEVCNM 494
W+D K I A +DG R L S L+ P +IA+D + +YW D KIE +
Sbjct: 513 WTDSGNK--TISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGL 570
Query: 495 DGTERKELHSNDI 507
+G +R+ L S++I
Sbjct: 571 NGVDRQTLVSDNI 583
Score = 57.2 bits (132), Expect = 3e-07
Identities = 60/240 (25%), Positives = 92/240 (38%), Gaps = 28/240 (11%)
Query: 863 GSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVG 922
G N+C +NGGCSH+C D++ + C CPA ++L D TC + +E +A
Sbjct: 336 GLNECLHNNGGCSHICT----DLKIGFECTCPAGFQL-LDQKTCGDIDE---CKDPDACS 387
Query: 923 RIMV-----ANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXX 977
+I V EC Y KN +A K + + H +RR+ +
Sbjct: 388 QICVNYKGYFKCECYPGYEMDLLTKNCKA----AAGKSPSLIFTNRHEVRRIDLVKRNYS 443
Query: 978 XXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNS---STGVIVRGDRM 1034
L ++V +YW I + +D S V++
Sbjct: 444 RLIPMLKNVVALD------VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH 497
Query: 1035 LPRHLAFHQTKRYLIWNDVGRGAIMRANVDGTGRVEL--ARADNATALALDQSAGTVYWA 1092
P LA +++ W D G I A VDG R L A+A+D G +YW+
Sbjct: 498 SPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWS 557
Score = 56.0 bits (129), Expect = 8e-07
Identities = 54/235 (22%), Positives = 101/235 (42%), Gaps = 21/235 (8%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYR---LNKDNITCSEPEEFLLFAQKNAVGRIMV 926
D CS +C+ G ++C C Y L K+ + L+F ++ V RI +
Sbjct: 382 DPDACSQICVNYKGY----FKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDL 437
Query: 927 ANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXX--XXXXXX 984
+ IP+ LKNV A++ + ++YW D S R++ +Y
Sbjct: 438 VKRNYS-RLIPM--LKNVVALDVEVATNRIYWCD---LSYRKIYSAYMDKASDPKEQEVL 491
Query: 985 XXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQT 1044
L P + +D + + +YWT + +I+ ++D + R + PR +A
Sbjct: 492 IDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSR-NLSEPRAIAVDPL 550
Query: 1045 KRYLIWNDVG-RGAIMRANVDGTGRVELARADN---ATALALDQSAGTVYWAVSR 1095
+ ++ W+D G + I ++ ++G R L +DN + LD + +YW S+
Sbjct: 551 RGFMYWSDWGDQAKIEKSGLNGVDRQTLV-SDNIEWPNGITLDLLSQRLYWVDSK 604
Score = 47.2 bits (107), Expect = 4e-04
Identities = 18/32 (56%), Positives = 21/32 (65%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F CD G CI R+ CDG +C DGSDE+ A C
Sbjct: 91 FTCDNGHCIHERWKCDGEEECPDGSDESEATC 122
Score = 44.0 bits (99), Expect = 0.003
Identities = 31/99 (31%), Positives = 40/99 (40%), Gaps = 16/99 (16%)
Query: 1096 QCDGQQDCEDGRDEAE-------CGA----CGGDV-RCADGT----XXXXXXXXXXXXXX 1139
+CDG+++C DG DE+E C A CG +C +
Sbjct: 104 KCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
Query: 1140 XXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAA 1178
F+C C+AA FVCDG C DGSDE A
Sbjct: 164 ATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCA 202
Score = 43.2 bits (97), Expect = 0.006
Identities = 34/102 (33%), Positives = 42/102 (41%), Gaps = 17/102 (16%)
Query: 1094 SRQCDGQQDCEDGRDEA-----------ECG--ACGGDVRCADGTXXXXXXXXXXXXXXX 1140
S +CDG++DCE G DEA +CG +C V DG
Sbjct: 145 SWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADP 204
Query: 1141 XXXXXDAFRCDE---GLCIAARFVCDGRPQCADGSDEAPAAC 1179
+ FRC G CI R+VCD + C D SDEA C
Sbjct: 205 ACGPRE-FRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELC 245
Score = 42.3 bits (95), Expect = 0.010
Identities = 18/33 (54%), Positives = 23/33 (69%), Gaps = 3/33 (9%)
Query: 1096 QCDGQQDCEDGRDEAEC--GACGGD-VRCADGT 1125
+CDG +DC+D DEA+C G C GD +C DGT
Sbjct: 278 RCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGT 310
Score = 35.9 bits (79), Expect = 0.87
Identities = 14/30 (46%), Positives = 18/30 (60%)
Query: 1146 DAFRCDEGLCIAARFVCDGRPQCADGSDEA 1175
D F+C +G C+ A C+ C DGSDEA
Sbjct: 302 DEFQCGDGTCVLAIKHCNQEQDCPDGSDEA 331
>AL606760-2|CAI18910.1| 904|Homo sapiens low density lipoprotein
receptor-related protein 8, apolipoprotein e receptor
protein.
Length = 904
Score = 185 bits (451), Expect = 7e-46
Identities = 105/308 (34%), Positives = 164/308 (53%), Gaps = 12/308 (3%)
Query: 17 LEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKI-VSEGLVTPTGIAIDWYT 75
L+ A+D N I W D I ++ ++ ++ + E L +P G+A+DW
Sbjct: 449 LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVH 508
Query: 76 DKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERA 135
+YWTD I V ++ R+ LF + RAIAV P G M+W+DWG+ KIE++
Sbjct: 509 KHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKS 568
Query: 136 GMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVKGG- 194
G+NG R+ +V DNI WPNGIT+D + +YWVD+KL + IDF+G RK ++
Sbjct: 569 GLNG--VDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTD 626
Query: 195 -LVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESRQII 253
L +PF + DK++WTD +N +I++ + NG +I L ++ P DI ++ E +Q
Sbjct: 627 FLSHPFGIAVFEDKVFWTDLENEAIFSAN-RLNGLEISILAENLNNPHDIVIFHELKQPR 685
Query: 254 SAEDYPCK-KNNAGCSHLCLLSPD----PPGYNCACPTGVKLRENSSTTCYDSPQMLLVV 308
+ + + N GC +LCL +P P Y CACP + L + CY +PQ
Sbjct: 686 APDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMK-RCYRAPQSTSTT 744
Query: 309 AQRSTISK 316
ST+++
Sbjct: 745 TLASTMTR 752
Score = 165 bits (401), Expect = 8e-40
Identities = 111/365 (30%), Positives = 175/365 (47%), Gaps = 31/365 (8%)
Query: 260 CKKNNAGCSHLCLLSPDPPGY-NCACPTGVK---LRENSSTTCYDSPQMLLVVAQRSTIS 315
CK +A CS +C+ + GY C C G + L +N SP L+ R +
Sbjct: 380 CKDPDA-CSQICV---NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPS--LIFTNRHEVR 433
Query: 316 KISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGS----DQSV 371
+I L +++ +P+ LK + +D + T IYW D + I A +D + +Q V
Sbjct: 434 RIDLVKRNYSRL-IPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEV 490
Query: 372 VVRSS-GVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLT 430
++ P+ +A+D + + IYWTD TI+VA +DG + + L +PRAIA+
Sbjct: 491 LIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPL 550
Query: 431 AGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIE 490
G+M+WSDW + + KIE++ L+G R L+S+ + WPN I LD ++ +LYW D++ H++
Sbjct: 551 RGFMYWSDWGD-QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS 609
Query: 491 VCNMDGTERKEL-HSNDII-HIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQM 548
+ G RK L S D + H FG ++ + N+ GL+ + E +
Sbjct: 610 SIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL 669
Query: 549 ANMMGVKAF-RLGAPLGWNPC---ADDNGGCSHLCFNRPD------DYICGCPLGLELTA 598
N + F L P + C NGGC +LC P Y C CP + L
Sbjct: 670 NNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGP 729
Query: 599 DKKTC 603
D K C
Sbjct: 730 DMKRC 734
Score = 163 bits (397), Expect = 3e-39
Identities = 100/355 (28%), Positives = 175/355 (49%), Gaps = 21/355 (5%)
Query: 571 DNGGCSHLCFNRPDDYICGCPLGLE---LTADKKTCVEPEAFLVYSRKNIIGRLSIKNEY 627
D CS +C N + C C G E LT + K L+++ ++ + R+ +
Sbjct: 382 DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRN 441
Query: 628 NDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEK-----IVEWLGLV 682
+IP+ LK V AL + V+ +++YW D + I ++ ++ K I E L
Sbjct: 442 YSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSP 499
Query: 683 EGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
EGLA+DW ++IYWTD+ + I V+ +DG RR + + L +P++I +DP +G+MYWS+
Sbjct: 500 EGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW 559
Query: 743 GSKS-IKRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQ 800
G ++ I+++ ++G ++ + + + + +D + +YW + +G R+
Sbjct: 560 GDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRK 619
Query: 801 TL---ADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYH 857
TL D + P+ +A+F D V+W D I A + +G + ++L+ D+ ++H
Sbjct: 620 TLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFH 679
Query: 858 RAKS-MGSNQCGVD---NGGCSHLCLPTP--GDVRTDYRCACPAHYRLNKDNITC 906
K + C + NGGC +LCLP P Y CACP L D C
Sbjct: 680 ELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
Score = 108 bits (260), Expect = 1e-22
Identities = 79/301 (26%), Positives = 141/301 (46%), Gaps = 12/301 (3%)
Query: 560 GAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIG 619
G G N C +NGGCSH+C + + C CP G +L D+KTC + + + I
Sbjct: 332 GCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGDIDECKDPDACSQI- 389
Query: 620 RLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWL 679
++ K + P ++ ++ +G + + R + +++ L
Sbjct: 390 CVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPML 449
Query: 680 GLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSS----RRAIIWQGLKKPKSIVLDPKKG 735
V L ++ + IYW D + ++I + +D +S + +I + L P+ + +D
Sbjct: 450 KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHK 509
Query: 736 YMYWSELGSKSIKRAAMDGS-SVSVFMEQVGRVHALAIDYERRAIYWAAL-DPPVVEFAF 793
++YW++ G+K+I A +DG ++F + A+A+D R +YW+ D +E +
Sbjct: 510 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSG 569
Query: 794 LNGTGRQTL-ADNIPMP--YALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYI 850
LNG RQTL +DNI P L L + +YW D Q+ G NRK++ D++
Sbjct: 570 LNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSI-DFSGGNRKTLISSTDFL 628
Query: 851 S 851
S
Sbjct: 629 S 629
Score = 73.3 bits (172), Expect = 5e-12
Identities = 62/253 (24%), Positives = 109/253 (43%), Gaps = 14/253 (5%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISL 319
C NN GCSH+C + G+ C CP G +L + + D + +Q K
Sbjct: 340 CLHNNGGCSHIC--TDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 397
Query: 320 DSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGVP 379
+ Y + L L + I+ + I + + S ++++
Sbjct: 398 KCECYPGYEMDL--LTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVAL 455
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLDGS----YEKVIIHTELYDPRAIALHLTAGWMF 435
D ++ + +IYW D I A +D + ++V+I +L+ P +A+ ++
Sbjct: 456 D---VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
Query: 436 WSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGD-ARTHKIEVCNM 494
W+D K I A +DG R L S L+ P +IA+D + +YW D KIE +
Sbjct: 513 WTDSGNK--TISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGL 570
Query: 495 DGTERKELHSNDI 507
+G +R+ L S++I
Sbjct: 571 NGVDRQTLVSDNI 583
Score = 57.2 bits (132), Expect = 3e-07
Identities = 60/240 (25%), Positives = 92/240 (38%), Gaps = 28/240 (11%)
Query: 863 GSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVG 922
G N+C +NGGCSH+C D++ + C CPA ++L D TC + +E +A
Sbjct: 336 GLNECLHNNGGCSHICT----DLKIGFECTCPAGFQL-LDQKTCGDIDE---CKDPDACS 387
Query: 923 RIMV-----ANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXX 977
+I V EC Y KN +A K + + H +RR+ +
Sbjct: 388 QICVNYKGYFKCECYPGYEMDLLTKNCKA----AAGKSPSLIFTNRHEVRRIDLVKRNYS 443
Query: 978 XXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNS---STGVIVRGDRM 1034
L ++V +YW I + +D S V++
Sbjct: 444 RLIPMLKNVVALD------VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH 497
Query: 1035 LPRHLAFHQTKRYLIWNDVGRGAIMRANVDGTGRVEL--ARADNATALALDQSAGTVYWA 1092
P LA +++ W D G I A VDG R L A+A+D G +YW+
Sbjct: 498 SPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWS 557
Score = 56.0 bits (129), Expect = 8e-07
Identities = 54/235 (22%), Positives = 101/235 (42%), Gaps = 21/235 (8%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYR---LNKDNITCSEPEEFLLFAQKNAVGRIMV 926
D CS +C+ G ++C C Y L K+ + L+F ++ V RI +
Sbjct: 382 DPDACSQICVNYKGY----FKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDL 437
Query: 927 ANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXX--XXXXXX 984
+ IP+ LKNV A++ + ++YW D S R++ +Y
Sbjct: 438 VKRNYS-RLIPM--LKNVVALDVEVATNRIYWCD---LSYRKIYSAYMDKASDPKEQEVL 491
Query: 985 XXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQT 1044
L P + +D + + +YWT + +I+ ++D + R + PR +A
Sbjct: 492 IDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSR-NLSEPRAIAVDPL 550
Query: 1045 KRYLIWNDVG-RGAIMRANVDGTGRVELARADN---ATALALDQSAGTVYWAVSR 1095
+ ++ W+D G + I ++ ++G R L +DN + LD + +YW S+
Sbjct: 551 RGFMYWSDWGDQAKIEKSGLNGVDRQTLV-SDNIEWPNGITLDLLSQRLYWVDSK 604
Score = 47.2 bits (107), Expect = 4e-04
Identities = 18/32 (56%), Positives = 21/32 (65%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F CD G CI R+ CDG +C DGSDE+ A C
Sbjct: 91 FTCDNGHCIHERWKCDGEEECPDGSDESEATC 122
Score = 44.0 bits (99), Expect = 0.003
Identities = 31/99 (31%), Positives = 40/99 (40%), Gaps = 16/99 (16%)
Query: 1096 QCDGQQDCEDGRDEAE-------CGA----CGGDV-RCADGT----XXXXXXXXXXXXXX 1139
+CDG+++C DG DE+E C A CG +C +
Sbjct: 104 KCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
Query: 1140 XXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAA 1178
F+C C+AA FVCDG C DGSDE A
Sbjct: 164 ATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCA 202
Score = 43.2 bits (97), Expect = 0.006
Identities = 34/102 (33%), Positives = 42/102 (41%), Gaps = 17/102 (16%)
Query: 1094 SRQCDGQQDCEDGRDEA-----------ECG--ACGGDVRCADGTXXXXXXXXXXXXXXX 1140
S +CDG++DCE G DEA +CG +C V DG
Sbjct: 145 SWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADP 204
Query: 1141 XXXXXDAFRCDE---GLCIAARFVCDGRPQCADGSDEAPAAC 1179
+ FRC G CI R+VCD + C D SDEA C
Sbjct: 205 ACGPRE-FRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELC 245
Score = 42.3 bits (95), Expect = 0.010
Identities = 18/33 (54%), Positives = 23/33 (69%), Gaps = 3/33 (9%)
Query: 1096 QCDGQQDCEDGRDEAEC--GACGGD-VRCADGT 1125
+CDG +DC+D DEA+C G C GD +C DGT
Sbjct: 278 RCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGT 310
Score = 35.9 bits (79), Expect = 0.87
Identities = 14/30 (46%), Positives = 18/30 (60%)
Query: 1146 DAFRCDEGLCIAARFVCDGRPQCADGSDEA 1175
D F+C +G C+ A C+ C DGSDEA
Sbjct: 302 DEFQCGDGTCVLAIKHCNQEQDCPDGSDEA 331
>AL355483-2|CAI22780.1| 904|Homo sapiens low density lipoprotein
receptor-related protein 8, apolipoprotein e receptor
protein.
Length = 904
Score = 185 bits (451), Expect = 7e-46
Identities = 105/308 (34%), Positives = 164/308 (53%), Gaps = 12/308 (3%)
Query: 17 LEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKI-VSEGLVTPTGIAIDWYT 75
L+ A+D N I W D I ++ ++ ++ + E L +P G+A+DW
Sbjct: 449 LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVH 508
Query: 76 DKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERA 135
+YWTD I V ++ R+ LF + RAIAV P G M+W+DWG+ KIE++
Sbjct: 509 KHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKS 568
Query: 136 GMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVKGG- 194
G+NG R+ +V DNI WPNGIT+D + +YWVD+KL + IDF+G RK ++
Sbjct: 569 GLNG--VDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTD 626
Query: 195 -LVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESRQII 253
L +PF + DK++WTD +N +I++ + NG +I L ++ P DI ++ E +Q
Sbjct: 627 FLSHPFGIAVFEDKVFWTDLENEAIFSAN-RLNGLEISILAENLNNPHDIVIFHELKQPR 685
Query: 254 SAEDYPCK-KNNAGCSHLCLLSPD----PPGYNCACPTGVKLRENSSTTCYDSPQMLLVV 308
+ + + N GC +LCL +P P Y CACP + L + CY +PQ
Sbjct: 686 APDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMK-RCYRAPQSTSTT 744
Query: 309 AQRSTISK 316
ST+++
Sbjct: 745 TLASTMTR 752
Score = 165 bits (401), Expect = 8e-40
Identities = 111/365 (30%), Positives = 175/365 (47%), Gaps = 31/365 (8%)
Query: 260 CKKNNAGCSHLCLLSPDPPGY-NCACPTGVK---LRENSSTTCYDSPQMLLVVAQRSTIS 315
CK +A CS +C+ + GY C C G + L +N SP L+ R +
Sbjct: 380 CKDPDA-CSQICV---NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPS--LIFTNRHEVR 433
Query: 316 KISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGS----DQSV 371
+I L +++ +P+ LK + +D + T IYW D + I A +D + +Q V
Sbjct: 434 RIDLVKRNYSRL-IPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEV 490
Query: 372 VVRSS-GVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLT 430
++ P+ +A+D + + IYWTD TI+VA +DG + + L +PRAIA+
Sbjct: 491 LIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPL 550
Query: 431 AGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIE 490
G+M+WSDW + + KIE++ L+G R L+S+ + WPN I LD ++ +LYW D++ H++
Sbjct: 551 RGFMYWSDWGD-QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS 609
Query: 491 VCNMDGTERKEL-HSNDII-HIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQM 548
+ G RK L S D + H FG ++ + N+ GL+ + E +
Sbjct: 610 SIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL 669
Query: 549 ANMMGVKAF-RLGAPLGWNPC---ADDNGGCSHLCFNRPD------DYICGCPLGLELTA 598
N + F L P + C NGGC +LC P Y C CP + L
Sbjct: 670 NNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGP 729
Query: 599 DKKTC 603
D K C
Sbjct: 730 DMKRC 734
Score = 163 bits (397), Expect = 3e-39
Identities = 100/355 (28%), Positives = 175/355 (49%), Gaps = 21/355 (5%)
Query: 571 DNGGCSHLCFNRPDDYICGCPLGLE---LTADKKTCVEPEAFLVYSRKNIIGRLSIKNEY 627
D CS +C N + C C G E LT + K L+++ ++ + R+ +
Sbjct: 382 DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRN 441
Query: 628 NDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEK-----IVEWLGLV 682
+IP+ LK V AL + V+ +++YW D + I ++ ++ K I E L
Sbjct: 442 YSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSP 499
Query: 683 EGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
EGLA+DW ++IYWTD+ + I V+ +DG RR + + L +P++I +DP +G+MYWS+
Sbjct: 500 EGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW 559
Query: 743 GSKS-IKRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQ 800
G ++ I+++ ++G ++ + + + + +D + +YW + +G R+
Sbjct: 560 GDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRK 619
Query: 801 TL---ADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYH 857
TL D + P+ +A+F D V+W D I A + +G + ++L+ D+ ++H
Sbjct: 620 TLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFH 679
Query: 858 RAKS-MGSNQCGVD---NGGCSHLCLPTP--GDVRTDYRCACPAHYRLNKDNITC 906
K + C + NGGC +LCLP P Y CACP L D C
Sbjct: 680 ELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
Score = 108 bits (260), Expect = 1e-22
Identities = 79/301 (26%), Positives = 141/301 (46%), Gaps = 12/301 (3%)
Query: 560 GAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIG 619
G G N C +NGGCSH+C + + C CP G +L D+KTC + + + I
Sbjct: 332 GCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGDIDECKDPDACSQI- 389
Query: 620 RLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWL 679
++ K + P ++ ++ +G + + R + +++ L
Sbjct: 390 CVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPML 449
Query: 680 GLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSS----RRAIIWQGLKKPKSIVLDPKKG 735
V L ++ + IYW D + ++I + +D +S + +I + L P+ + +D
Sbjct: 450 KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHK 509
Query: 736 YMYWSELGSKSIKRAAMDGS-SVSVFMEQVGRVHALAIDYERRAIYWAAL-DPPVVEFAF 793
++YW++ G+K+I A +DG ++F + A+A+D R +YW+ D +E +
Sbjct: 510 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSG 569
Query: 794 LNGTGRQTL-ADNIPMP--YALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYI 850
LNG RQTL +DNI P L L + +YW D Q+ G NRK++ D++
Sbjct: 570 LNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSI-DFSGGNRKTLISSTDFL 628
Query: 851 S 851
S
Sbjct: 629 S 629
Score = 73.3 bits (172), Expect = 5e-12
Identities = 62/253 (24%), Positives = 109/253 (43%), Gaps = 14/253 (5%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISL 319
C NN GCSH+C + G+ C CP G +L + + D + +Q K
Sbjct: 340 CLHNNGGCSHIC--TDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 397
Query: 320 DSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGVP 379
+ Y + L L + I+ + I + + S ++++
Sbjct: 398 KCECYPGYEMDL--LTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVAL 455
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLDGS----YEKVIIHTELYDPRAIALHLTAGWMF 435
D ++ + +IYW D I A +D + ++V+I +L+ P +A+ ++
Sbjct: 456 D---VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
Query: 436 WSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGD-ARTHKIEVCNM 494
W+D K I A +DG R L S L+ P +IA+D + +YW D KIE +
Sbjct: 513 WTDSGNK--TISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGL 570
Query: 495 DGTERKELHSNDI 507
+G +R+ L S++I
Sbjct: 571 NGVDRQTLVSDNI 583
Score = 57.2 bits (132), Expect = 3e-07
Identities = 60/240 (25%), Positives = 92/240 (38%), Gaps = 28/240 (11%)
Query: 863 GSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVG 922
G N+C +NGGCSH+C D++ + C CPA ++L D TC + +E +A
Sbjct: 336 GLNECLHNNGGCSHICT----DLKIGFECTCPAGFQL-LDQKTCGDIDE---CKDPDACS 387
Query: 923 RIMV-----ANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXX 977
+I V EC Y KN +A K + + H +RR+ +
Sbjct: 388 QICVNYKGYFKCECYPGYEMDLLTKNCKA----AAGKSPSLIFTNRHEVRRIDLVKRNYS 443
Query: 978 XXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNS---STGVIVRGDRM 1034
L ++V +YW I + +D S V++
Sbjct: 444 RLIPMLKNVVALD------VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH 497
Query: 1035 LPRHLAFHQTKRYLIWNDVGRGAIMRANVDGTGRVEL--ARADNATALALDQSAGTVYWA 1092
P LA +++ W D G I A VDG R L A+A+D G +YW+
Sbjct: 498 SPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWS 557
Score = 56.0 bits (129), Expect = 8e-07
Identities = 54/235 (22%), Positives = 101/235 (42%), Gaps = 21/235 (8%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYR---LNKDNITCSEPEEFLLFAQKNAVGRIMV 926
D CS +C+ G ++C C Y L K+ + L+F ++ V RI +
Sbjct: 382 DPDACSQICVNYKGY----FKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDL 437
Query: 927 ANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXX--XXXXXX 984
+ IP+ LKNV A++ + ++YW D S R++ +Y
Sbjct: 438 VKRNYS-RLIPM--LKNVVALDVEVATNRIYWCD---LSYRKIYSAYMDKASDPKEQEVL 491
Query: 985 XXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQT 1044
L P + +D + + +YWT + +I+ ++D + R + PR +A
Sbjct: 492 IDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSR-NLSEPRAIAVDPL 550
Query: 1045 KRYLIWNDVG-RGAIMRANVDGTGRVELARADN---ATALALDQSAGTVYWAVSR 1095
+ ++ W+D G + I ++ ++G R L +DN + LD + +YW S+
Sbjct: 551 RGFMYWSDWGDQAKIEKSGLNGVDRQTLV-SDNIEWPNGITLDLLSQRLYWVDSK 604
Score = 47.2 bits (107), Expect = 4e-04
Identities = 18/32 (56%), Positives = 21/32 (65%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F CD G CI R+ CDG +C DGSDE+ A C
Sbjct: 91 FTCDNGHCIHERWKCDGEEECPDGSDESEATC 122
Score = 44.0 bits (99), Expect = 0.003
Identities = 31/99 (31%), Positives = 40/99 (40%), Gaps = 16/99 (16%)
Query: 1096 QCDGQQDCEDGRDEAE-------CGA----CGGDV-RCADGT----XXXXXXXXXXXXXX 1139
+CDG+++C DG DE+E C A CG +C +
Sbjct: 104 KCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
Query: 1140 XXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAA 1178
F+C C+AA FVCDG C DGSDE A
Sbjct: 164 ATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCA 202
Score = 43.2 bits (97), Expect = 0.006
Identities = 34/102 (33%), Positives = 42/102 (41%), Gaps = 17/102 (16%)
Query: 1094 SRQCDGQQDCEDGRDEA-----------ECG--ACGGDVRCADGTXXXXXXXXXXXXXXX 1140
S +CDG++DCE G DEA +CG +C V DG
Sbjct: 145 SWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADP 204
Query: 1141 XXXXXDAFRCDE---GLCIAARFVCDGRPQCADGSDEAPAAC 1179
+ FRC G CI R+VCD + C D SDEA C
Sbjct: 205 ACGPRE-FRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELC 245
Score = 42.3 bits (95), Expect = 0.010
Identities = 18/33 (54%), Positives = 23/33 (69%), Gaps = 3/33 (9%)
Query: 1096 QCDGQQDCEDGRDEAEC--GACGGD-VRCADGT 1125
+CDG +DC+D DEA+C G C GD +C DGT
Sbjct: 278 RCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGT 310
Score = 35.9 bits (79), Expect = 0.87
Identities = 14/30 (46%), Positives = 18/30 (60%)
Query: 1146 DAFRCDEGLCIAARFVCDGRPQCADGSDEA 1175
D F+C +G C+ A C+ C DGSDEA
Sbjct: 302 DEFQCGDGTCVLAIKHCNQEQDCPDGSDEA 331
>AL355483-1|CAI22781.1| 963|Homo sapiens low density lipoprotein
receptor-related protein 8, apolipoprotein e receptor
protein.
Length = 963
Score = 185 bits (451), Expect = 7e-46
Identities = 105/308 (34%), Positives = 164/308 (53%), Gaps = 12/308 (3%)
Query: 17 LEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKI-VSEGLVTPTGIAIDWYT 75
L+ A+D N I W D I ++ ++ ++ + E L +P G+A+DW
Sbjct: 449 LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVH 508
Query: 76 DKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERA 135
+YWTD I V ++ R+ LF + RAIAV P G M+W+DWG+ KIE++
Sbjct: 509 KHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKS 568
Query: 136 GMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVKGG- 194
G+NG R+ +V DNI WPNGIT+D + +YWVD+KL + IDF+G RK ++
Sbjct: 569 GLNG--VDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTD 626
Query: 195 -LVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESRQII 253
L +PF + DK++WTD +N +I++ + NG +I L ++ P DI ++ E +Q
Sbjct: 627 FLSHPFGIAVFEDKVFWTDLENEAIFSAN-RLNGLEISILAENLNNPHDIVIFHELKQPR 685
Query: 254 SAEDYPCK-KNNAGCSHLCLLSPD----PPGYNCACPTGVKLRENSSTTCYDSPQMLLVV 308
+ + + N GC +LCL +P P Y CACP + L + CY +PQ
Sbjct: 686 APDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMK-RCYRAPQSTSTT 744
Query: 309 AQRSTISK 316
ST+++
Sbjct: 745 TLASTMTR 752
Score = 165 bits (401), Expect = 8e-40
Identities = 111/365 (30%), Positives = 175/365 (47%), Gaps = 31/365 (8%)
Query: 260 CKKNNAGCSHLCLLSPDPPGY-NCACPTGVK---LRENSSTTCYDSPQMLLVVAQRSTIS 315
CK +A CS +C+ + GY C C G + L +N SP L+ R +
Sbjct: 380 CKDPDA-CSQICV---NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPS--LIFTNRHEVR 433
Query: 316 KISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGS----DQSV 371
+I L +++ +P+ LK + +D + T IYW D + I A +D + +Q V
Sbjct: 434 RIDLVKRNYSRL-IPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEV 490
Query: 372 VVRSS-GVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLT 430
++ P+ +A+D + + IYWTD TI+VA +DG + + L +PRAIA+
Sbjct: 491 LIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPL 550
Query: 431 AGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIE 490
G+M+WSDW + + KIE++ L+G R L+S+ + WPN I LD ++ +LYW D++ H++
Sbjct: 551 RGFMYWSDWGD-QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS 609
Query: 491 VCNMDGTERKEL-HSNDII-HIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQM 548
+ G RK L S D + H FG ++ + N+ GL+ + E +
Sbjct: 610 SIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL 669
Query: 549 ANMMGVKAF-RLGAPLGWNPC---ADDNGGCSHLCFNRPD------DYICGCPLGLELTA 598
N + F L P + C NGGC +LC P Y C CP + L
Sbjct: 670 NNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGP 729
Query: 599 DKKTC 603
D K C
Sbjct: 730 DMKRC 734
Score = 163 bits (397), Expect = 3e-39
Identities = 100/355 (28%), Positives = 175/355 (49%), Gaps = 21/355 (5%)
Query: 571 DNGGCSHLCFNRPDDYICGCPLGLE---LTADKKTCVEPEAFLVYSRKNIIGRLSIKNEY 627
D CS +C N + C C G E LT + K L+++ ++ + R+ +
Sbjct: 382 DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRN 441
Query: 628 NDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEK-----IVEWLGLV 682
+IP+ LK V AL + V+ +++YW D + I ++ ++ K I E L
Sbjct: 442 YSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSP 499
Query: 683 EGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
EGLA+DW ++IYWTD+ + I V+ +DG RR + + L +P++I +DP +G+MYWS+
Sbjct: 500 EGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW 559
Query: 743 GSKS-IKRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQ 800
G ++ I+++ ++G ++ + + + + +D + +YW + +G R+
Sbjct: 560 GDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRK 619
Query: 801 TL---ADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYH 857
TL D + P+ +A+F D V+W D I A + +G + ++L+ D+ ++H
Sbjct: 620 TLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFH 679
Query: 858 RAKS-MGSNQCGVD---NGGCSHLCLPTP--GDVRTDYRCACPAHYRLNKDNITC 906
K + C + NGGC +LCLP P Y CACP L D C
Sbjct: 680 ELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
Score = 108 bits (260), Expect = 1e-22
Identities = 79/301 (26%), Positives = 141/301 (46%), Gaps = 12/301 (3%)
Query: 560 GAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIG 619
G G N C +NGGCSH+C + + C CP G +L D+KTC + + + I
Sbjct: 332 GCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGDIDECKDPDACSQI- 389
Query: 620 RLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWL 679
++ K + P ++ ++ +G + + R + +++ L
Sbjct: 390 CVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPML 449
Query: 680 GLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSS----RRAIIWQGLKKPKSIVLDPKKG 735
V L ++ + IYW D + ++I + +D +S + +I + L P+ + +D
Sbjct: 450 KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHK 509
Query: 736 YMYWSELGSKSIKRAAMDGS-SVSVFMEQVGRVHALAIDYERRAIYWAAL-DPPVVEFAF 793
++YW++ G+K+I A +DG ++F + A+A+D R +YW+ D +E +
Sbjct: 510 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSG 569
Query: 794 LNGTGRQTL-ADNIPMP--YALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYI 850
LNG RQTL +DNI P L L + +YW D Q+ G NRK++ D++
Sbjct: 570 LNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSI-DFSGGNRKTLISSTDFL 628
Query: 851 S 851
S
Sbjct: 629 S 629
Score = 73.3 bits (172), Expect = 5e-12
Identities = 62/253 (24%), Positives = 109/253 (43%), Gaps = 14/253 (5%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISL 319
C NN GCSH+C + G+ C CP G +L + + D + +Q K
Sbjct: 340 CLHNNGGCSHIC--TDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 397
Query: 320 DSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGVP 379
+ Y + L L + I+ + I + + S ++++
Sbjct: 398 KCECYPGYEMDL--LTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVAL 455
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLDGS----YEKVIIHTELYDPRAIALHLTAGWMF 435
D ++ + +IYW D I A +D + ++V+I +L+ P +A+ ++
Sbjct: 456 D---VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
Query: 436 WSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGD-ARTHKIEVCNM 494
W+D K I A +DG R L S L+ P +IA+D + +YW D KIE +
Sbjct: 513 WTDSGNK--TISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGL 570
Query: 495 DGTERKELHSNDI 507
+G +R+ L S++I
Sbjct: 571 NGVDRQTLVSDNI 583
Score = 57.2 bits (132), Expect = 3e-07
Identities = 60/240 (25%), Positives = 92/240 (38%), Gaps = 28/240 (11%)
Query: 863 GSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVG 922
G N+C +NGGCSH+C D++ + C CPA ++L D TC + +E +A
Sbjct: 336 GLNECLHNNGGCSHICT----DLKIGFECTCPAGFQL-LDQKTCGDIDE---CKDPDACS 387
Query: 923 RIMV-----ANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXX 977
+I V EC Y KN +A K + + H +RR+ +
Sbjct: 388 QICVNYKGYFKCECYPGYEMDLLTKNCKA----AAGKSPSLIFTNRHEVRRIDLVKRNYS 443
Query: 978 XXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNS---STGVIVRGDRM 1034
L ++V +YW I + +D S V++
Sbjct: 444 RLIPMLKNVVALD------VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH 497
Query: 1035 LPRHLAFHQTKRYLIWNDVGRGAIMRANVDGTGRVEL--ARADNATALALDQSAGTVYWA 1092
P LA +++ W D G I A VDG R L A+A+D G +YW+
Sbjct: 498 SPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWS 557
Score = 56.0 bits (129), Expect = 8e-07
Identities = 54/235 (22%), Positives = 101/235 (42%), Gaps = 21/235 (8%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYR---LNKDNITCSEPEEFLLFAQKNAVGRIMV 926
D CS +C+ G ++C C Y L K+ + L+F ++ V RI +
Sbjct: 382 DPDACSQICVNYKGY----FKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDL 437
Query: 927 ANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXX--XXXXXX 984
+ IP+ LKNV A++ + ++YW D S R++ +Y
Sbjct: 438 VKRNYS-RLIPM--LKNVVALDVEVATNRIYWCD---LSYRKIYSAYMDKASDPKEQEVL 491
Query: 985 XXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQT 1044
L P + +D + + +YWT + +I+ ++D + R + PR +A
Sbjct: 492 IDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSR-NLSEPRAIAVDPL 550
Query: 1045 KRYLIWNDVG-RGAIMRANVDGTGRVELARADN---ATALALDQSAGTVYWAVSR 1095
+ ++ W+D G + I ++ ++G R L +DN + LD + +YW S+
Sbjct: 551 RGFMYWSDWGDQAKIEKSGLNGVDRQTLV-SDNIEWPNGITLDLLSQRLYWVDSK 604
Score = 47.2 bits (107), Expect = 4e-04
Identities = 18/32 (56%), Positives = 21/32 (65%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F CD G CI R+ CDG +C DGSDE+ A C
Sbjct: 91 FTCDNGHCIHERWKCDGEEECPDGSDESEATC 122
Score = 44.0 bits (99), Expect = 0.003
Identities = 31/99 (31%), Positives = 40/99 (40%), Gaps = 16/99 (16%)
Query: 1096 QCDGQQDCEDGRDEAE-------CGA----CGGDV-RCADGT----XXXXXXXXXXXXXX 1139
+CDG+++C DG DE+E C A CG +C +
Sbjct: 104 KCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
Query: 1140 XXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAA 1178
F+C C+AA FVCDG C DGSDE A
Sbjct: 164 ATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCA 202
Score = 43.2 bits (97), Expect = 0.006
Identities = 34/102 (33%), Positives = 42/102 (41%), Gaps = 17/102 (16%)
Query: 1094 SRQCDGQQDCEDGRDEA-----------ECG--ACGGDVRCADGTXXXXXXXXXXXXXXX 1140
S +CDG++DCE G DEA +CG +C V DG
Sbjct: 145 SWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADP 204
Query: 1141 XXXXXDAFRCDE---GLCIAARFVCDGRPQCADGSDEAPAAC 1179
+ FRC G CI R+VCD + C D SDEA C
Sbjct: 205 ACGPRE-FRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELC 245
Score = 42.3 bits (95), Expect = 0.010
Identities = 18/33 (54%), Positives = 23/33 (69%), Gaps = 3/33 (9%)
Query: 1096 QCDGQQDCEDGRDEAEC--GACGGD-VRCADGT 1125
+CDG +DC+D DEA+C G C GD +C DGT
Sbjct: 278 RCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGT 310
Score = 35.9 bits (79), Expect = 0.87
Identities = 14/30 (46%), Positives = 18/30 (60%)
Query: 1146 DAFRCDEGLCIAARFVCDGRPQCADGSDEA 1175
D F+C +G C+ A C+ C DGSDEA
Sbjct: 302 DEFQCGDGTCVLAIKHCNQEQDCPDGSDEA 331
>Z75190-1|CAA99509.1| 699|Homo sapiens apolipoprotein E receptor 2
906 protein.
Length = 699
Score = 179 bits (435), Expect = 6e-44
Identities = 99/277 (35%), Positives = 150/277 (54%), Gaps = 11/277 (3%)
Query: 17 LEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTG-EKFKIVSEGLVTPTGIAIDWYT 75
L+ A+D N I W D I ++ E+ ++ E L +P G+A+DW
Sbjct: 319 LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEREVLIDEQLHSPEGLAVDWVH 378
Query: 76 DKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERA 135
+YWTD I V ++ R+ LF + RAIAV P G M+W+DWG+ KIE++
Sbjct: 379 KHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKS 438
Query: 136 GMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVKGG- 194
G+NG R+ +V DNI WPNGIT+D + +YWVD+KL + IDF+G RK ++
Sbjct: 439 GLNG--VDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTD 496
Query: 195 -LVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESRQII 253
L +PF + DK++WTD +N +I++ + NG +I L ++ P DI ++ E +Q
Sbjct: 497 FLSHPFGIAVFEDKVFWTDLENEAIFSAN-RLNGLEISILAENLNNPHDIVIFHELKQPR 555
Query: 254 SAEDYPCK-KNNAGCSHLCLLSPD----PPGYNCACP 285
+ + + N GC +LCL +P P Y CACP
Sbjct: 556 APDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACP 592
Score = 161 bits (392), Expect = 1e-38
Identities = 111/365 (30%), Positives = 171/365 (46%), Gaps = 32/365 (8%)
Query: 260 CKKNNAGCSHLCLLSPDPPGY-NCACPTGVK---LRENSSTTCYDSPQMLLVVAQRSTIS 315
CK +A CS +C+ + GY C C G + L +N SP L+ R++
Sbjct: 251 CKDPDA-CSQICV---NYKGYFKCECYPGCEMDLLTKNCKAAAGKSPS--LIFTNRTSAE 304
Query: 316 KISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLD-GSD----QS 370
D P Y+ + LK + +D + T IYW D + I A +D SD +
Sbjct: 305 ----DRPVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEREV 360
Query: 371 VVVRSSGVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLT 430
++ P+ +A+D + + IYWTD TI+VA +DG + + L +PRAIA+
Sbjct: 361 LIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPL 420
Query: 431 AGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIE 490
G+M+WSDW + + KIE++ L+G R L+S+ + WPN I LD ++ +LYW D++ H++
Sbjct: 421 RGFMYWSDWGD-QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS 479
Query: 491 VCNMDGTERKEL-HSNDII-HIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQM 548
+ G RK L S D + H FG ++ + N+ GL+ + E +
Sbjct: 480 SIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL 539
Query: 549 ANMMGVKAF-RLGAPLGWNPC---ADDNGGCSHLCFNRPD------DYICGCPLGLELTA 598
N + F L P + C NGGC +LC P Y C CP + L
Sbjct: 540 NNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGP 599
Query: 599 DKKTC 603
D K C
Sbjct: 600 DMKRC 604
Score = 161 bits (390), Expect = 2e-38
Identities = 101/355 (28%), Positives = 174/355 (49%), Gaps = 22/355 (6%)
Query: 571 DNGGCSHLCFNRPDDYICGCPLGLE---LTADKKTCVEPEAFLVYSRKNIIGRLSIKNEY 627
D CS +C N + C C G E LT + K L+++ + +K Y
Sbjct: 253 DPDACSQICVNYKGYFKCECYPGCEMDLLTKNCKAAAGKSPSLIFTNRTSAEDRPVKRNY 312
Query: 628 NDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEK-----IVEWLGLV 682
+ +IP+ LK V AL + V+ +++YW D + I ++ ++ K I E L
Sbjct: 313 S-RLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEREVLIDEQLHSP 369
Query: 683 EGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
EGLA+DW ++IYWTD+ + I V+ +DG RR + + L +P++I +DP +G+MYWS+
Sbjct: 370 EGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW 429
Query: 743 GSKS-IKRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQ 800
G ++ I+++ ++G ++ + + + + +D + +YW + +G R+
Sbjct: 430 GDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRK 489
Query: 801 TL---ADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYH 857
TL D + P+ +A+F D V+W D I A + +G + ++L+ D+ ++H
Sbjct: 490 TLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFH 549
Query: 858 RAKS-MGSNQCGVD---NGGCSHLCLPTP--GDVRTDYRCACPAHYRLNKDNITC 906
K + C + NGGC +LCLP P Y CACP L D C
Sbjct: 550 ELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 604
Score = 106 bits (255), Expect = 4e-22
Identities = 86/305 (28%), Positives = 145/305 (47%), Gaps = 21/305 (6%)
Query: 560 GAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIG 619
G G N C +NGGCSH+C + + C CP G +L D+KTC + + + I
Sbjct: 203 GCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGDIDECKDPDACSQI- 260
Query: 620 RLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVE----KI 675
++ K + P ++ ++ +G S S T NR S V+ ++
Sbjct: 261 CVNYKGYFKCECYPGCEMDLLTKNCKAAAGK----SPSLIFT-NRTSAEDRPVKRNYSRL 315
Query: 676 VEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSS----RRAIIWQGLKKPKSIVLD 731
+ L V L ++ + IYW D + ++I + +D +S R +I + L P+ + +D
Sbjct: 316 IPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEREVLIDEQLHSPEGLAVD 375
Query: 732 PKKGYMYWSELGSKSIKRAAMDGS-SVSVFMEQVGRVHALAIDYERRAIYWAAL-DPPVV 789
++YW++ G+K+I A +DG ++F + A+A+D R +YW+ D +
Sbjct: 376 WVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKI 435
Query: 790 EFAFLNGTGRQTL-ADNIPMP--YALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKD 846
E + LNG RQTL +DNI P L L + +YW D Q+ G NRK++
Sbjct: 436 EKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSI-DFSGGNRKTLISS 494
Query: 847 LDYIS 851
D++S
Sbjct: 495 TDFLS 499
Score = 49.2 bits (112), Expect = 9e-05
Identities = 50/232 (21%), Positives = 95/232 (40%), Gaps = 16/232 (6%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVANG 929
D CS +C+ G + + C L K+ + L+F + + V
Sbjct: 253 DPDACSQICVNYKGYFKCECYPGCEMDL-LTKNCKAAAGKSPSLIFTNRTSAEDRPVKRN 311
Query: 930 ECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXX--XXXXXXXXX 987
IP+ LKNV A++ + ++YW D S R++ +Y
Sbjct: 312 YSR--LIPM--LKNVVALDVEVATNRIYWCD---LSYRKIYSAYMDKASDPKEREVLIDE 364
Query: 988 GLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRY 1047
L P + +D + + +YWT + +I+ ++D + R + PR +A + +
Sbjct: 365 QLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSR-NLSEPRAIAVDPLRGF 423
Query: 1048 LIWNDVG-RGAIMRANVDGTGRVELARADN---ATALALDQSAGTVYWAVSR 1095
+ W+D G + I ++ ++G R L +DN + LD + +YW S+
Sbjct: 424 MYWSDWGDQAKIEKSGLNGVDRQTLV-SDNIEWPNGITLDLLSQRLYWVDSK 474
Score = 47.2 bits (107), Expect = 4e-04
Identities = 18/32 (56%), Positives = 21/32 (65%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F CD G CI R+ CDG +C DGSDE+ A C
Sbjct: 91 FTCDNGHCIHERWKCDGEEECPDGSDESEATC 122
Score = 45.2 bits (102), Expect = 0.001
Identities = 20/49 (40%), Positives = 30/49 (61%), Gaps = 5/49 (10%)
Query: 863 GSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
G N+C +NGGCSH+C D++ + C CPA ++L D TC + +E
Sbjct: 207 GLNECLHNNGGCSHICT----DLKIGFECTCPAGFQL-LDQKTCGDIDE 250
Score = 43.2 bits (97), Expect = 0.006
Identities = 28/82 (34%), Positives = 35/82 (42%), Gaps = 24/82 (29%)
Query: 1094 SRQCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEG 1153
S +CDG++DCE G DEA C G R D F+C +G
Sbjct: 145 SWRCDGEKDCEGGADEAGCATSLGTCR------------------------GDEFQCGDG 180
Query: 1154 LCIAARFVCDGRPQCADGSDEA 1175
C+ A C+ C DGSDEA
Sbjct: 181 TCVLAIKHCNQEQDCPDGSDEA 202
Score = 37.5 bits (83), Expect = 0.29
Identities = 17/41 (41%), Positives = 22/41 (53%), Gaps = 4/41 (9%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYD 300
C NN GCSH+C + G+ C CP G +L + TC D
Sbjct: 211 CLHNNGGCSHIC--TDLKIGFECTCPAGFQLLDQK--TCGD 247
>S73849-1|AAB31735.1| 873|Homo sapiens very low density lipoprotein
receptor protein.
Length = 873
Score = 178 bits (434), Expect = 8e-44
Identities = 100/289 (34%), Positives = 159/289 (55%), Gaps = 15/289 (5%)
Query: 13 IAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAID 72
+ + L A+D + W+D + I + ++ G K++ + + P IA+D
Sbjct: 464 LVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDK-VGRHVKMI-DNVYNPAAIAVD 521
Query: 73 WYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKI 132
W +YWTD + I V ++ RK LF S++ +IAV P G ++W+DWGE KI
Sbjct: 522 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKI 581
Query: 133 ERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVK 192
E+AGMNG R+ +V +I WPNGIT+D S +YW+D+KL + +D NG+ R+ V+K
Sbjct: 582 EKAGMNG--FDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLK 639
Query: 193 G--GLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESR 250
L +P ALT D++YW D +N ++Y + G ++ L+ + DI VY E
Sbjct: 640 SLEFLAHPLALTIFEDRVYWIDGENEAVYGAN-KFTGSELATLVNNLNDAQDIIVYHELV 698
Query: 251 QIISAEDYPCKKN--NAGCSHLCLLSPD----PPGYNCACPTGVKLREN 293
Q S +++ C+++ N GC +LCL +P P Y C+CP+G + EN
Sbjct: 699 Q-PSGKNW-CEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEEN 745
Score = 173 bits (420), Expect = 4e-42
Identities = 98/359 (27%), Positives = 176/359 (49%), Gaps = 16/359 (4%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTC--VEPEAFLVYSRKNIIGRLSIKNEYNDA 630
G CS +C N Y C C G ++ C V E L+++ + I ++ + E +
Sbjct: 404 GICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGL--ERKEY 461
Query: 631 VIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVE--KIVEWLGLVEGLAID 688
+ ++ L+ AL ++ KL+W+D K I S++ K+++ + +A+D
Sbjct: 462 IQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVD 521
Query: 689 WSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS-I 747
W + IYWTD ++ I V+ LDG+ R+ + L++P SI +DP G++YWS+ G + I
Sbjct: 522 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKI 581
Query: 748 KRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNI 806
++A M+G + + + + +D + +YW ++ LNG R+ + ++
Sbjct: 582 EKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSL 641
Query: 807 PM---PYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHR-AKSM 862
P AL +F D VYW D + A K GS ++ +L+ D+ +YH +
Sbjct: 642 EFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPS 701
Query: 863 GSNQC--GVDNGGCSHLCLPTP--GDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQ 917
G N C ++NGGC +LCLP P D Y C+CP+ Y + ++ C + +++
Sbjct: 702 GKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSE 760
Score = 169 bits (410), Expect = 7e-41
Identities = 105/365 (28%), Positives = 174/365 (47%), Gaps = 19/365 (5%)
Query: 262 KNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDS 321
+N CS +C+ GY C C G ++ + + L+ R I KI L+
Sbjct: 401 QNPGICSQICINLKG--GYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLER 458
Query: 322 PDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGV--P 379
+ Y ++ L+ T+ +D D + ++WAD K I A +D V V P
Sbjct: 459 KE---YIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNP 515
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDW 439
+IA+D + + IYWTD TI+VA LDG+ K + +++L +P +IA+ +G+++WSDW
Sbjct: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
Query: 440 NEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTER 499
E KIE+A ++G R L++ + WPN I LD + ++LYW D++ H + +++G +R
Sbjct: 576 GE-PAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDR 634
Query: 500 K-ELHSNDII-HIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAF 557
+ L S + + H + + NK TG + +V + + + +
Sbjct: 635 RIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVY 694
Query: 558 -RLGAPLGWNPCADD--NGGCSHLCFNRPD------DYICGCPLGLELTADKKTCVEPEA 608
L P G N C +D NGGC +LC P Y C CP G + + + C
Sbjct: 695 HELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTAT 754
Query: 609 FLVYS 613
+ YS
Sbjct: 755 TVTYS 759
Score = 83.8 bits (198), Expect = 3e-15
Identities = 71/294 (24%), Positives = 129/294 (43%), Gaps = 14/294 (4%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGR--LSI 623
N C +NGGCSH+C + Y C C G EL D+KTC + + I + +++
Sbjct: 358 NECLVNNGGCSHICKDLVIGYECDCAAGFEL-IDRKTCGDIDE---CQNPGICSQICINL 413
Query: 624 KNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVE 683
K Y + + + V G + + + I + + ++VE L
Sbjct: 414 KGGYKCECSRGYQMDLATGVCKAV-GKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTV 472
Query: 684 GLAIDWSGQNIYWTDTTTQRIEVSRLDGS-SRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
L D + Q ++W D + + I + +D R + + P +I +D +YW++
Sbjct: 473 ALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDA 532
Query: 743 GSKSIKRAAMDGSSVS-VFMEQVGRVHALAIDYERRAIYWAAL-DPPVVEFAFLNGTGRQ 800
SK+I A +DG+ +F + ++A+D +YW+ +P +E A +NG R+
Sbjct: 533 ASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRR 592
Query: 801 TL--AD-NIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYIS 851
L AD P L L +YW D + +G +R+ + K L++++
Sbjct: 593 PLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSV-DLNGQDRRIVLKSLEFLA 645
Score = 74.9 bits (176), Expect = 2e-12
Identities = 69/252 (27%), Positives = 108/252 (42%), Gaps = 16/252 (6%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISL 319
C NN GCSH+C GY C C G +L + + D Q + +Q K
Sbjct: 360 CLVNNGGCSHIC--KDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGY 417
Query: 320 DSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGVP 379
Y + DL + + I+ + I K L+ + +V
Sbjct: 418 KCECSRGYQM---DLATGVCKAVGKEPSLIFTN---RRDIRKIGLERKEYIQLVEQLRNT 471
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLD---GSYEKVIIHTELYDPRAIALHLTAGWMFW 436
++ D ++K++W D I A +D G + K+I +Y+P AIA+ ++W
Sbjct: 472 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNPAAIAVDWVYKTIYW 529
Query: 437 SDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGD-ARTHKIEVCNMD 495
+D K I A LDG+ R L + L P SIA+D ++ +YW D KIE M+
Sbjct: 530 TDAASK--TISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMN 587
Query: 496 GTERKELHSNDI 507
G +R+ L + DI
Sbjct: 588 GFDRRPLVTADI 599
Score = 61.7 bits (143), Expect = 2e-08
Identities = 59/256 (23%), Positives = 105/256 (41%), Gaps = 20/256 (7%)
Query: 846 DLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNIT 905
+ D + +L R ++C + G CS +C+ G Y+C C Y+++
Sbjct: 379 ECDCAAGFELIDRKTCGDIDECQ-NPGICSQICINLKGG----YKCECSRGYQMDLATGV 433
Query: 906 CSE--PEEFLLFAQKNAVGRIMVANGECNDAYIPLTG-LKNVRAIEYDPVEKQLYWMDDD 962
C E L+F + + +I + E YI L L+N A++ D ++L+W D
Sbjct: 434 CKAVGKEPSLIFTNRRDIRKIGLERKE----YIQLVEQLRNTVALDADIAAQKLFWADLS 489
Query: 963 SHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNN 1022
+I S + P + +D + +T+YWT A +I+ ++D
Sbjct: 490 QKAI----FSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLD-G 544
Query: 1023 SSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGA-IMRANVDGTGRVELARADN--ATA 1079
+ + D P +A ++ W+D G A I +A ++G R L AD
Sbjct: 545 TKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNG 604
Query: 1080 LALDQSAGTVYWAVSR 1095
+ LD +YW S+
Sbjct: 605 ITLDLIKSRLYWLDSK 620
Score = 55.2 bits (127), Expect = 1e-06
Identities = 54/232 (23%), Positives = 92/232 (39%), Gaps = 20/232 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL--FAQKNAVG 922
N+C V+NGGCSH+C D+ Y C C A + L D TC + +E + +
Sbjct: 358 NECLVNNGGCSHIC----KDLVIGYECDCAAGFEL-IDRKTCGDIDECQNPGICSQICIN 412
Query: 923 RIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXX 982
EC+ Y +A+ +P L + + IR++ +
Sbjct: 413 LKGGYKCECSRGYQMDLATGVCKAVGKEP---SLIF--TNRRDIRKIGLERKEYIQLVEQ 467
Query: 983 XXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFH 1042
L D+ + ++W + +I + SID+ V + + P +A
Sbjct: 468 LRNTVALD------ADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVD 521
Query: 1043 QTKRYLIWNDVGRGAIMRANVDGTGRVELARAD--NATALALDQSAGTVYWA 1092
+ + W D I A +DGT R L +D ++A+D +G VYW+
Sbjct: 522 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWS 573
Score = 53.2 bits (122), Expect = 5e-06
Identities = 32/90 (35%), Positives = 42/90 (46%), Gaps = 29/90 (32%)
Query: 1093 VSRQCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDE 1152
VS +CDG+ DC+ G DE CG ++ C+ D F C
Sbjct: 130 VSWRCDGENDCDSGEDEENCG----NITCSP----------------------DEFTCSS 163
Query: 1153 GLCIAARFVCDGRPQCADGSDE---APAAC 1179
G CI+ FVC+G+ C+DGSDE AP C
Sbjct: 164 GRCISRNFVCNGQDDCSDGSDELDCAPPTC 193
Score = 52.4 bits (120), Expect = 9e-06
Identities = 28/85 (32%), Positives = 37/85 (43%), Gaps = 9/85 (10%)
Query: 1096 QCDGQQ-DCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGL 1154
+C+ Q C +GR C GD C DG+ F C+ G
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESD--------FVCNNGQ 83
Query: 1155 CIAARFVCDGRPQCADGSDEAPAAC 1179
C+ +R+ CDG P C DGSDE+P C
Sbjct: 84 CVPSRWKCDGDPDCEDGSDESPEQC 108
Score = 43.6 bits (98), Expect = 0.004
Identities = 30/99 (30%), Positives = 38/99 (38%), Gaps = 22/99 (22%)
Query: 1097 CDGQQDCEDGRDEAEC-----GA----------------CGGDVRCADGTXXXXXXXXXX 1135
C+GQ DC DG DE +C GA C D C+D +
Sbjct: 173 CNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQ 232
Query: 1136 XXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
+ +C G CI ++ CDG P C DGSDE
Sbjct: 233 PVIHTKCPASE-IQCGSGECIHKKWRCDGDPDCKDGSDE 270
Score = 37.5 bits (83), Expect = 0.29
Identities = 28/99 (28%), Positives = 34/99 (34%), Gaps = 15/99 (15%)
Query: 1096 QCDGQQDCEDGRDEAECGA--CGGD-VRCADGTXXXXXXXXXXXXXXXXXXXX------- 1145
+CDG DC+DG DE C + C D C DG+
Sbjct: 257 RCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVN 316
Query: 1146 -----DAFRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F+C G CI VC+ C D SDE C
Sbjct: 317 QCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKEC 355
Score = 33.1 bits (72), Expect = 6.2
Identities = 12/19 (63%), Positives = 14/19 (73%)
Query: 1094 SRQCDGQQDCEDGRDEAEC 1112
SRQC+G +DC DG DE C
Sbjct: 294 SRQCNGIRDCVDGSDEVNC 312
>L22431-1|AAA61344.1| 873|Homo sapiens very low density lipoprotein
receptor protein.
Length = 873
Score = 178 bits (434), Expect = 8e-44
Identities = 100/289 (34%), Positives = 159/289 (55%), Gaps = 15/289 (5%)
Query: 13 IAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAID 72
+ + L A+D + W+D + I + ++ G K++ + + P IA+D
Sbjct: 464 LVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDK-VGRHVKMI-DNVYNPAAIAVD 521
Query: 73 WYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKI 132
W +YWTD + I V ++ RK LF S++ +IAV P G ++W+DWGE KI
Sbjct: 522 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKI 581
Query: 133 ERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVK 192
E+AGMNG R+ +V +I WPNGIT+D S +YW+D+KL + +D NG+ R+ V+K
Sbjct: 582 EKAGMNG--FDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLK 639
Query: 193 G--GLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESR 250
L +P ALT D++YW D +N ++Y + G ++ L+ + DI VY E
Sbjct: 640 SLEFLAHPLALTIFEDRVYWIDGENEAVYGAN-KFTGSELATLVNNLNDAQDIIVYHELV 698
Query: 251 QIISAEDYPCKKN--NAGCSHLCLLSPD----PPGYNCACPTGVKLREN 293
Q S +++ C+++ N GC +LCL +P P Y C+CP+G + EN
Sbjct: 699 Q-PSGKNW-CEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEEN 745
Score = 173 bits (420), Expect = 4e-42
Identities = 98/359 (27%), Positives = 176/359 (49%), Gaps = 16/359 (4%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTC--VEPEAFLVYSRKNIIGRLSIKNEYNDA 630
G CS +C N Y C C G ++ C V E L+++ + I ++ + E +
Sbjct: 404 GICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGL--ERKEY 461
Query: 631 VIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVE--KIVEWLGLVEGLAID 688
+ ++ L+ AL ++ KL+W+D K I S++ K+++ + +A+D
Sbjct: 462 IQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVD 521
Query: 689 WSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS-I 747
W + IYWTD ++ I V+ LDG+ R+ + L++P SI +DP G++YWS+ G + I
Sbjct: 522 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKI 581
Query: 748 KRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNI 806
++A M+G + + + + +D + +YW ++ LNG R+ + ++
Sbjct: 582 EKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSL 641
Query: 807 PM---PYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHR-AKSM 862
P AL +F D VYW D + A K GS ++ +L+ D+ +YH +
Sbjct: 642 EFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPS 701
Query: 863 GSNQC--GVDNGGCSHLCLPTP--GDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQ 917
G N C ++NGGC +LCLP P D Y C+CP+ Y + ++ C + +++
Sbjct: 702 GKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSE 760
Score = 169 bits (410), Expect = 7e-41
Identities = 105/365 (28%), Positives = 174/365 (47%), Gaps = 19/365 (5%)
Query: 262 KNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDS 321
+N CS +C+ GY C C G ++ + + L+ R I KI L+
Sbjct: 401 QNPGICSQICINLKG--GYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLER 458
Query: 322 PDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGV--P 379
+ Y ++ L+ T+ +D D + ++WAD K I A +D V V P
Sbjct: 459 KE---YIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNP 515
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDW 439
+IA+D + + IYWTD TI+VA LDG+ K + +++L +P +IA+ +G+++WSDW
Sbjct: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
Query: 440 NEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTER 499
E KIE+A ++G R L++ + WPN I LD + ++LYW D++ H + +++G +R
Sbjct: 576 GE-PAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDR 634
Query: 500 K-ELHSNDII-HIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAF 557
+ L S + + H + + NK TG + +V + + + +
Sbjct: 635 RIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVY 694
Query: 558 -RLGAPLGWNPCADD--NGGCSHLCFNRPD------DYICGCPLGLELTADKKTCVEPEA 608
L P G N C +D NGGC +LC P Y C CP G + + + C
Sbjct: 695 HELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTAT 754
Query: 609 FLVYS 613
+ YS
Sbjct: 755 TVTYS 759
Score = 83.8 bits (198), Expect = 3e-15
Identities = 71/294 (24%), Positives = 129/294 (43%), Gaps = 14/294 (4%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGR--LSI 623
N C +NGGCSH+C + Y C C G EL D+KTC + + I + +++
Sbjct: 358 NECLVNNGGCSHICKDLVIGYECDCAAGFEL-IDRKTCGDIDE---CQNPGICSQICINL 413
Query: 624 KNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVE 683
K Y + + + V G + + + I + + ++VE L
Sbjct: 414 KGGYKCECSRGYQMDLATGVCKAV-GKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTV 472
Query: 684 GLAIDWSGQNIYWTDTTTQRIEVSRLDGS-SRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
L D + Q ++W D + + I + +D R + + P +I +D +YW++
Sbjct: 473 ALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDA 532
Query: 743 GSKSIKRAAMDGSSVS-VFMEQVGRVHALAIDYERRAIYWAAL-DPPVVEFAFLNGTGRQ 800
SK+I A +DG+ +F + ++A+D +YW+ +P +E A +NG R+
Sbjct: 533 ASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRR 592
Query: 801 TL--AD-NIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYIS 851
L AD P L L +YW D + +G +R+ + K L++++
Sbjct: 593 PLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSV-DLNGQDRRIVLKSLEFLA 645
Score = 74.9 bits (176), Expect = 2e-12
Identities = 69/252 (27%), Positives = 108/252 (42%), Gaps = 16/252 (6%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISL 319
C NN GCSH+C GY C C G +L + + D Q + +Q K
Sbjct: 360 CLVNNGGCSHIC--KDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGY 417
Query: 320 DSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGVP 379
Y + DL + + I+ + I K L+ + +V
Sbjct: 418 KCECSRGYQM---DLATGVCKAVGKEPSLIFTN---RRDIRKIGLERKEYIQLVEQLRNT 471
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLD---GSYEKVIIHTELYDPRAIALHLTAGWMFW 436
++ D ++K++W D I A +D G + K+I +Y+P AIA+ ++W
Sbjct: 472 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNPAAIAVDWVYKTIYW 529
Query: 437 SDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGD-ARTHKIEVCNMD 495
+D K I A LDG+ R L + L P SIA+D ++ +YW D KIE M+
Sbjct: 530 TDAASK--TISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMN 587
Query: 496 GTERKELHSNDI 507
G +R+ L + DI
Sbjct: 588 GFDRRPLVTADI 599
Score = 61.7 bits (143), Expect = 2e-08
Identities = 59/256 (23%), Positives = 105/256 (41%), Gaps = 20/256 (7%)
Query: 846 DLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNIT 905
+ D + +L R ++C + G CS +C+ G Y+C C Y+++
Sbjct: 379 ECDCAAGFELIDRKTCGDIDECQ-NPGICSQICINLKGG----YKCECSRGYQMDLATGV 433
Query: 906 CSE--PEEFLLFAQKNAVGRIMVANGECNDAYIPLTG-LKNVRAIEYDPVEKQLYWMDDD 962
C E L+F + + +I + E YI L L+N A++ D ++L+W D
Sbjct: 434 CKAVGKEPSLIFTNRRDIRKIGLERKE----YIQLVEQLRNTVALDADIAAQKLFWADLS 489
Query: 963 SHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNN 1022
+I S + P + +D + +T+YWT A +I+ ++D
Sbjct: 490 QKAI----FSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLD-G 544
Query: 1023 SSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGA-IMRANVDGTGRVELARADN--ATA 1079
+ + D P +A ++ W+D G A I +A ++G R L AD
Sbjct: 545 TKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNG 604
Query: 1080 LALDQSAGTVYWAVSR 1095
+ LD +YW S+
Sbjct: 605 ITLDLIKSRLYWLDSK 620
Score = 55.2 bits (127), Expect = 1e-06
Identities = 54/232 (23%), Positives = 92/232 (39%), Gaps = 20/232 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL--FAQKNAVG 922
N+C V+NGGCSH+C D+ Y C C A + L D TC + +E + +
Sbjct: 358 NECLVNNGGCSHIC----KDLVIGYECDCAAGFEL-IDRKTCGDIDECQNPGICSQICIN 412
Query: 923 RIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXX 982
EC+ Y +A+ +P L + + IR++ +
Sbjct: 413 LKGGYKCECSRGYQMDLATGVCKAVGKEP---SLIF--TNRRDIRKIGLERKEYIQLVEQ 467
Query: 983 XXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFH 1042
L D+ + ++W + +I + SID+ V + + P +A
Sbjct: 468 LRNTVALD------ADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVD 521
Query: 1043 QTKRYLIWNDVGRGAIMRANVDGTGRVELARAD--NATALALDQSAGTVYWA 1092
+ + W D I A +DGT R L +D ++A+D +G VYW+
Sbjct: 522 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWS 573
Score = 53.2 bits (122), Expect = 5e-06
Identities = 32/90 (35%), Positives = 42/90 (46%), Gaps = 29/90 (32%)
Query: 1093 VSRQCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDE 1152
VS +CDG+ DC+ G DE CG ++ C+ D F C
Sbjct: 130 VSWRCDGENDCDSGEDEENCG----NITCSP----------------------DEFTCSS 163
Query: 1153 GLCIAARFVCDGRPQCADGSDE---APAAC 1179
G CI+ FVC+G+ C+DGSDE AP C
Sbjct: 164 GRCISRNFVCNGQDDCSDGSDELDCAPPTC 193
Score = 52.4 bits (120), Expect = 9e-06
Identities = 28/85 (32%), Positives = 37/85 (43%), Gaps = 9/85 (10%)
Query: 1096 QCDGQQ-DCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGL 1154
+C+ Q C +GR C GD C DG+ F C+ G
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESD--------FVCNNGQ 83
Query: 1155 CIAARFVCDGRPQCADGSDEAPAAC 1179
C+ +R+ CDG P C DGSDE+P C
Sbjct: 84 CVPSRWKCDGDPDCEDGSDESPEQC 108
Score = 43.6 bits (98), Expect = 0.004
Identities = 30/99 (30%), Positives = 38/99 (38%), Gaps = 22/99 (22%)
Query: 1097 CDGQQDCEDGRDEAEC-----GA----------------CGGDVRCADGTXXXXXXXXXX 1135
C+GQ DC DG DE +C GA C D C+D +
Sbjct: 173 CNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQ 232
Query: 1136 XXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
+ +C G CI ++ CDG P C DGSDE
Sbjct: 233 PVIHTKCPASE-IQCGSGECIHKKWRCDGDPDCKDGSDE 270
Score = 37.5 bits (83), Expect = 0.29
Identities = 28/99 (28%), Positives = 34/99 (34%), Gaps = 15/99 (15%)
Query: 1096 QCDGQQDCEDGRDEAECGA--CGGD-VRCADGTXXXXXXXXXXXXXXXXXXXX------- 1145
+CDG DC+DG DE C + C D C DG+
Sbjct: 257 RCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVN 316
Query: 1146 -----DAFRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F+C G CI VC+ C D SDE C
Sbjct: 317 QCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKEC 355
Score = 33.1 bits (72), Expect = 6.2
Identities = 12/19 (63%), Positives = 14/19 (73%)
Query: 1094 SRQCDGQQDCEDGRDEAEC 1112
SRQC+G +DC DG DE C
Sbjct: 294 SRQCNGIRDCVDGSDEVNC 312
>D16532-1|BAA03969.1| 873|Homo sapiens very low density lipoprotein
receptor protein.
Length = 873
Score = 178 bits (434), Expect = 8e-44
Identities = 100/289 (34%), Positives = 159/289 (55%), Gaps = 15/289 (5%)
Query: 13 IAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAID 72
+ + L A+D + W+D + I + ++ G K++ + + P IA+D
Sbjct: 464 LVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDK-VGRHVKMI-DNVYNPAAIAVD 521
Query: 73 WYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKI 132
W +YWTD + I V ++ RK LF S++ +IAV P G ++W+DWGE KI
Sbjct: 522 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKI 581
Query: 133 ERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVK 192
E+AGMNG R+ +V +I WPNGIT+D S +YW+D+KL + +D NG+ R+ V+K
Sbjct: 582 EKAGMNG--FDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLK 639
Query: 193 G--GLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESR 250
L +P ALT D++YW D +N ++Y + G ++ L+ + DI VY E
Sbjct: 640 SLEFLAHPLALTIFEDRVYWIDGENEAVYGAN-KFTGSELATLVNNLNDAQDIIVYHELV 698
Query: 251 QIISAEDYPCKKN--NAGCSHLCLLSPD----PPGYNCACPTGVKLREN 293
Q S +++ C+++ N GC +LCL +P P Y C+CP+G + EN
Sbjct: 699 Q-PSGKNW-CEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEEN 745
Score = 173 bits (420), Expect = 4e-42
Identities = 98/359 (27%), Positives = 176/359 (49%), Gaps = 16/359 (4%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTC--VEPEAFLVYSRKNIIGRLSIKNEYNDA 630
G CS +C N Y C C G ++ C V E L+++ + I ++ + E +
Sbjct: 404 GICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGL--ERKEY 461
Query: 631 VIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVE--KIVEWLGLVEGLAID 688
+ ++ L+ AL ++ KL+W+D K I S++ K+++ + +A+D
Sbjct: 462 IQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVD 521
Query: 689 WSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS-I 747
W + IYWTD ++ I V+ LDG+ R+ + L++P SI +DP G++YWS+ G + I
Sbjct: 522 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKI 581
Query: 748 KRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNI 806
++A M+G + + + + +D + +YW ++ LNG R+ + ++
Sbjct: 582 EKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSL 641
Query: 807 PM---PYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHR-AKSM 862
P AL +F D VYW D + A K GS ++ +L+ D+ +YH +
Sbjct: 642 EFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPS 701
Query: 863 GSNQC--GVDNGGCSHLCLPTP--GDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQ 917
G N C ++NGGC +LCLP P D Y C+CP+ Y + ++ C + +++
Sbjct: 702 GKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSE 760
Score = 169 bits (410), Expect = 7e-41
Identities = 105/365 (28%), Positives = 174/365 (47%), Gaps = 19/365 (5%)
Query: 262 KNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDS 321
+N CS +C+ GY C C G ++ + + L+ R I KI L+
Sbjct: 401 QNPGICSQICINLKG--GYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLER 458
Query: 322 PDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGV--P 379
+ Y ++ L+ T+ +D D + ++WAD K I A +D V V P
Sbjct: 459 KE---YIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNP 515
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDW 439
+IA+D + + IYWTD TI+VA LDG+ K + +++L +P +IA+ +G+++WSDW
Sbjct: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
Query: 440 NEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTER 499
E KIE+A ++G R L++ + WPN I LD + ++LYW D++ H + +++G +R
Sbjct: 576 GE-PAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDR 634
Query: 500 K-ELHSNDII-HIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAF 557
+ L S + + H + + NK TG + +V + + + +
Sbjct: 635 RIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVY 694
Query: 558 -RLGAPLGWNPCADD--NGGCSHLCFNRPD------DYICGCPLGLELTADKKTCVEPEA 608
L P G N C +D NGGC +LC P Y C CP G + + + C
Sbjct: 695 HELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTAT 754
Query: 609 FLVYS 613
+ YS
Sbjct: 755 TVTYS 759
Score = 83.8 bits (198), Expect = 3e-15
Identities = 71/294 (24%), Positives = 129/294 (43%), Gaps = 14/294 (4%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGR--LSI 623
N C +NGGCSH+C + Y C C G EL D+KTC + + I + +++
Sbjct: 358 NECLVNNGGCSHICKDLVIGYECDCAAGFEL-IDRKTCGDIDE---CQNPGICSQICINL 413
Query: 624 KNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVE 683
K Y + + + V G + + + I + + ++VE L
Sbjct: 414 KGGYKCECSRGYQMDLATGVCKAV-GKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTV 472
Query: 684 GLAIDWSGQNIYWTDTTTQRIEVSRLDGS-SRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
L D + Q ++W D + + I + +D R + + P +I +D +YW++
Sbjct: 473 ALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDA 532
Query: 743 GSKSIKRAAMDGSSVS-VFMEQVGRVHALAIDYERRAIYWAAL-DPPVVEFAFLNGTGRQ 800
SK+I A +DG+ +F + ++A+D +YW+ +P +E A +NG R+
Sbjct: 533 ASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRR 592
Query: 801 TL--AD-NIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYIS 851
L AD P L L +YW D + +G +R+ + K L++++
Sbjct: 593 PLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSV-DLNGQDRRIVLKSLEFLA 645
Score = 74.9 bits (176), Expect = 2e-12
Identities = 69/252 (27%), Positives = 108/252 (42%), Gaps = 16/252 (6%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISL 319
C NN GCSH+C GY C C G +L + + D Q + +Q K
Sbjct: 360 CLVNNGGCSHIC--KDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGY 417
Query: 320 DSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGVP 379
Y + DL + + I+ + I K L+ + +V
Sbjct: 418 KCECSRGYQM---DLATGVCKAVGKEPSLIFTN---RRDIRKIGLERKEYIQLVEQLRNT 471
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLD---GSYEKVIIHTELYDPRAIALHLTAGWMFW 436
++ D ++K++W D I A +D G + K+I +Y+P AIA+ ++W
Sbjct: 472 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNPAAIAVDWVYKTIYW 529
Query: 437 SDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGD-ARTHKIEVCNMD 495
+D K I A LDG+ R L + L P SIA+D ++ +YW D KIE M+
Sbjct: 530 TDAASK--TISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMN 587
Query: 496 GTERKELHSNDI 507
G +R+ L + DI
Sbjct: 588 GFDRRPLVTADI 599
Score = 61.7 bits (143), Expect = 2e-08
Identities = 59/256 (23%), Positives = 105/256 (41%), Gaps = 20/256 (7%)
Query: 846 DLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNIT 905
+ D + +L R ++C + G CS +C+ G Y+C C Y+++
Sbjct: 379 ECDCAAGFELIDRKTCGDIDECQ-NPGICSQICINLKGG----YKCECSRGYQMDLATGV 433
Query: 906 CSE--PEEFLLFAQKNAVGRIMVANGECNDAYIPLTG-LKNVRAIEYDPVEKQLYWMDDD 962
C E L+F + + +I + E YI L L+N A++ D ++L+W D
Sbjct: 434 CKAVGKEPSLIFTNRRDIRKIGLERKE----YIQLVEQLRNTVALDADIAAQKLFWADLS 489
Query: 963 SHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNN 1022
+I S + P + +D + +T+YWT A +I+ ++D
Sbjct: 490 QKAI----FSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLD-G 544
Query: 1023 SSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGA-IMRANVDGTGRVELARADN--ATA 1079
+ + D P +A ++ W+D G A I +A ++G R L AD
Sbjct: 545 TKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNG 604
Query: 1080 LALDQSAGTVYWAVSR 1095
+ LD +YW S+
Sbjct: 605 ITLDLIKSRLYWLDSK 620
Score = 55.2 bits (127), Expect = 1e-06
Identities = 54/232 (23%), Positives = 92/232 (39%), Gaps = 20/232 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL--FAQKNAVG 922
N+C V+NGGCSH+C D+ Y C C A + L D TC + +E + +
Sbjct: 358 NECLVNNGGCSHIC----KDLVIGYECDCAAGFEL-IDRKTCGDIDECQNPGICSQICIN 412
Query: 923 RIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXX 982
EC+ Y +A+ +P L + + IR++ +
Sbjct: 413 LKGGYKCECSRGYQMDLATGVCKAVGKEP---SLIF--TNRRDIRKIGLERKEYIQLVEQ 467
Query: 983 XXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFH 1042
L D+ + ++W + +I + SID+ V + + P +A
Sbjct: 468 LRNTVALD------ADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVD 521
Query: 1043 QTKRYLIWNDVGRGAIMRANVDGTGRVELARAD--NATALALDQSAGTVYWA 1092
+ + W D I A +DGT R L +D ++A+D +G VYW+
Sbjct: 522 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWS 573
Score = 53.2 bits (122), Expect = 5e-06
Identities = 32/90 (35%), Positives = 42/90 (46%), Gaps = 29/90 (32%)
Query: 1093 VSRQCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDE 1152
VS +CDG+ DC+ G DE CG ++ C+ D F C
Sbjct: 130 VSWRCDGENDCDSGEDEENCG----NITCSP----------------------DEFTCSS 163
Query: 1153 GLCIAARFVCDGRPQCADGSDE---APAAC 1179
G CI+ FVC+G+ C+DGSDE AP C
Sbjct: 164 GRCISRNFVCNGQDDCSDGSDELDCAPPTC 193
Score = 52.4 bits (120), Expect = 9e-06
Identities = 28/85 (32%), Positives = 37/85 (43%), Gaps = 9/85 (10%)
Query: 1096 QCDGQQ-DCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGL 1154
+C+ Q C +GR C GD C DG+ F C+ G
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESD--------FVCNNGQ 83
Query: 1155 CIAARFVCDGRPQCADGSDEAPAAC 1179
C+ +R+ CDG P C DGSDE+P C
Sbjct: 84 CVPSRWKCDGDPDCEDGSDESPEQC 108
Score = 43.6 bits (98), Expect = 0.004
Identities = 30/99 (30%), Positives = 38/99 (38%), Gaps = 22/99 (22%)
Query: 1097 CDGQQDCEDGRDEAEC-----GA----------------CGGDVRCADGTXXXXXXXXXX 1135
C+GQ DC DG DE +C GA C D C+D +
Sbjct: 173 CNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQ 232
Query: 1136 XXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
+ +C G CI ++ CDG P C DGSDE
Sbjct: 233 PVIHTKCPASE-IQCGSGECIHKKWRCDGDPDCKDGSDE 270
Score = 37.5 bits (83), Expect = 0.29
Identities = 28/99 (28%), Positives = 34/99 (34%), Gaps = 15/99 (15%)
Query: 1096 QCDGQQDCEDGRDEAECGA--CGGD-VRCADGTXXXXXXXXXXXXXXXXXXXX------- 1145
+CDG DC+DG DE C + C D C DG+
Sbjct: 257 RCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVN 316
Query: 1146 -----DAFRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F+C G CI VC+ C D SDE C
Sbjct: 317 QCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKEC 355
Score = 33.1 bits (72), Expect = 6.2
Identities = 12/19 (63%), Positives = 14/19 (73%)
Query: 1094 SRQCDGQQDCEDGRDEAEC 1112
SRQC+G +DC DG DE C
Sbjct: 294 SRQCNGIRDCVDGSDEVNC 312
>D16494-1|BAA03946.1| 845|Homo sapiens very low density lipoprotein
receptor protein.
Length = 845
Score = 178 bits (434), Expect = 8e-44
Identities = 100/289 (34%), Positives = 159/289 (55%), Gaps = 15/289 (5%)
Query: 13 IAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAID 72
+ + L A+D + W+D + I + ++ G K++ + + P IA+D
Sbjct: 464 LVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDK-VGRHVKMI-DNVYNPAAIAVD 521
Query: 73 WYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKI 132
W +YWTD + I V ++ RK LF S++ +IAV P G ++W+DWGE KI
Sbjct: 522 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKI 581
Query: 133 ERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVK 192
E+AGMNG R+ +V +I WPNGIT+D S +YW+D+KL + +D NG+ R+ V+K
Sbjct: 582 EKAGMNG--FDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLK 639
Query: 193 G--GLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESR 250
L +P ALT D++YW D +N ++Y + G ++ L+ + DI VY E
Sbjct: 640 SLEFLAHPLALTIFEDRVYWIDGENEAVYGAN-KFTGSELATLVNNLNDAQDIIVYHELV 698
Query: 251 QIISAEDYPCKKN--NAGCSHLCLLSPD----PPGYNCACPTGVKLREN 293
Q S +++ C+++ N GC +LCL +P P Y C+CP+G + EN
Sbjct: 699 Q-PSGKNW-CEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEEN 745
Score = 172 bits (419), Expect = 6e-42
Identities = 98/348 (28%), Positives = 172/348 (49%), Gaps = 16/348 (4%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTC--VEPEAFLVYSRKNIIGRLSIKNEYNDA 630
G CS +C N Y C C G ++ C V E L+++ + I ++ + E +
Sbjct: 404 GICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGL--ERKEY 461
Query: 631 VIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVE--KIVEWLGLVEGLAID 688
+ ++ L+ AL ++ KL+W+D K I S++ K+++ + +A+D
Sbjct: 462 IQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVD 521
Query: 689 WSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS-I 747
W + IYWTD ++ I V+ LDG+ R+ + L++P SI +DP G++YWS+ G + I
Sbjct: 522 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKI 581
Query: 748 KRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNI 806
++A M+G + + + + +D + +YW ++ LNG R+ + ++
Sbjct: 582 EKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSL 641
Query: 807 PM---PYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHR-AKSM 862
P AL +F D VYW D + A K GS ++ +L+ D+ +YH +
Sbjct: 642 EFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPS 701
Query: 863 GSNQC--GVDNGGCSHLCLPTP--GDVRTDYRCACPAHYRLNKDNITC 906
G N C ++NGGC +LCLP P D Y C+CP+ Y + ++ C
Sbjct: 702 GKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749
Score = 166 bits (404), Expect = 4e-40
Identities = 103/355 (29%), Positives = 171/355 (48%), Gaps = 19/355 (5%)
Query: 262 KNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDS 321
+N CS +C+ GY C C G ++ + + L+ R I KI L+
Sbjct: 401 QNPGICSQICINLKG--GYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLER 458
Query: 322 PDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGV--P 379
+ Y ++ L+ T+ +D D + ++WAD K I A +D V V P
Sbjct: 459 KE---YIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNP 515
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDW 439
+IA+D + + IYWTD TI+VA LDG+ K + +++L +P +IA+ +G+++WSDW
Sbjct: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
Query: 440 NEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTER 499
E KIE+A ++G R L++ + WPN I LD + ++LYW D++ H + +++G +R
Sbjct: 576 GE-PAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDR 634
Query: 500 K-ELHSNDII-HIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAF 557
+ L S + + H + + NK TG + +V + + + +
Sbjct: 635 RIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVY 694
Query: 558 -RLGAPLGWNPCADD--NGGCSHLCFNRPD------DYICGCPLGLELTADKKTC 603
L P G N C +D NGGC +LC P Y C CP G + + + C
Sbjct: 695 HELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749
Score = 83.8 bits (198), Expect = 3e-15
Identities = 71/294 (24%), Positives = 129/294 (43%), Gaps = 14/294 (4%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGR--LSI 623
N C +NGGCSH+C + Y C C G EL D+KTC + + I + +++
Sbjct: 358 NECLVNNGGCSHICKDLVIGYECDCAAGFEL-IDRKTCGDIDE---CQNPGICSQICINL 413
Query: 624 KNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVE 683
K Y + + + V G + + + I + + ++VE L
Sbjct: 414 KGGYKCECSRGYQMDLATGVCKAV-GKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTV 472
Query: 684 GLAIDWSGQNIYWTDTTTQRIEVSRLDGS-SRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
L D + Q ++W D + + I + +D R + + P +I +D +YW++
Sbjct: 473 ALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDA 532
Query: 743 GSKSIKRAAMDGSSVS-VFMEQVGRVHALAIDYERRAIYWAAL-DPPVVEFAFLNGTGRQ 800
SK+I A +DG+ +F + ++A+D +YW+ +P +E A +NG R+
Sbjct: 533 ASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRR 592
Query: 801 TL--AD-NIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYIS 851
L AD P L L +YW D + +G +R+ + K L++++
Sbjct: 593 PLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSV-DLNGQDRRIVLKSLEFLA 645
Score = 74.9 bits (176), Expect = 2e-12
Identities = 69/252 (27%), Positives = 108/252 (42%), Gaps = 16/252 (6%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISL 319
C NN GCSH+C GY C C G +L + + D Q + +Q K
Sbjct: 360 CLVNNGGCSHIC--KDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGY 417
Query: 320 DSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGVP 379
Y + DL + + I+ + I K L+ + +V
Sbjct: 418 KCECSRGYQM---DLATGVCKAVGKEPSLIFTN---RRDIRKIGLERKEYIQLVEQLRNT 471
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLD---GSYEKVIIHTELYDPRAIALHLTAGWMFW 436
++ D ++K++W D I A +D G + K+I +Y+P AIA+ ++W
Sbjct: 472 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNPAAIAVDWVYKTIYW 529
Query: 437 SDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGD-ARTHKIEVCNMD 495
+D K I A LDG+ R L + L P SIA+D ++ +YW D KIE M+
Sbjct: 530 TDAASK--TISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMN 587
Query: 496 GTERKELHSNDI 507
G +R+ L + DI
Sbjct: 588 GFDRRPLVTADI 599
Score = 61.7 bits (143), Expect = 2e-08
Identities = 59/256 (23%), Positives = 105/256 (41%), Gaps = 20/256 (7%)
Query: 846 DLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNIT 905
+ D + +L R ++C + G CS +C+ G Y+C C Y+++
Sbjct: 379 ECDCAAGFELIDRKTCGDIDECQ-NPGICSQICINLKGG----YKCECSRGYQMDLATGV 433
Query: 906 CSE--PEEFLLFAQKNAVGRIMVANGECNDAYIPLTG-LKNVRAIEYDPVEKQLYWMDDD 962
C E L+F + + +I + E YI L L+N A++ D ++L+W D
Sbjct: 434 CKAVGKEPSLIFTNRRDIRKIGLERKE----YIQLVEQLRNTVALDADIAAQKLFWADLS 489
Query: 963 SHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNN 1022
+I S + P + +D + +T+YWT A +I+ ++D
Sbjct: 490 QKAI----FSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLD-G 544
Query: 1023 SSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGA-IMRANVDGTGRVELARADN--ATA 1079
+ + D P +A ++ W+D G A I +A ++G R L AD
Sbjct: 545 TKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNG 604
Query: 1080 LALDQSAGTVYWAVSR 1095
+ LD +YW S+
Sbjct: 605 ITLDLIKSRLYWLDSK 620
Score = 55.2 bits (127), Expect = 1e-06
Identities = 54/232 (23%), Positives = 92/232 (39%), Gaps = 20/232 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL--FAQKNAVG 922
N+C V+NGGCSH+C D+ Y C C A + L D TC + +E + +
Sbjct: 358 NECLVNNGGCSHIC----KDLVIGYECDCAAGFEL-IDRKTCGDIDECQNPGICSQICIN 412
Query: 923 RIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXX 982
EC+ Y +A+ +P L + + IR++ +
Sbjct: 413 LKGGYKCECSRGYQMDLATGVCKAVGKEP---SLIF--TNRRDIRKIGLERKEYIQLVEQ 467
Query: 983 XXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFH 1042
L D+ + ++W + +I + SID+ V + + P +A
Sbjct: 468 LRNTVALD------ADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVD 521
Query: 1043 QTKRYLIWNDVGRGAIMRANVDGTGRVELARAD--NATALALDQSAGTVYWA 1092
+ + W D I A +DGT R L +D ++A+D +G VYW+
Sbjct: 522 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWS 573
Score = 53.2 bits (122), Expect = 5e-06
Identities = 32/90 (35%), Positives = 42/90 (46%), Gaps = 29/90 (32%)
Query: 1093 VSRQCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDE 1152
VS +CDG+ DC+ G DE CG ++ C+ D F C
Sbjct: 130 VSWRCDGENDCDSGEDEENCG----NITCSP----------------------DEFTCSS 163
Query: 1153 GLCIAARFVCDGRPQCADGSDE---APAAC 1179
G CI+ FVC+G+ C+DGSDE AP C
Sbjct: 164 GRCISRNFVCNGQDDCSDGSDELDCAPPTC 193
Score = 52.4 bits (120), Expect = 9e-06
Identities = 28/85 (32%), Positives = 37/85 (43%), Gaps = 9/85 (10%)
Query: 1096 QCDGQQ-DCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGL 1154
+C+ Q C +GR C GD C DG+ F C+ G
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESD--------FVCNNGQ 83
Query: 1155 CIAARFVCDGRPQCADGSDEAPAAC 1179
C+ +R+ CDG P C DGSDE+P C
Sbjct: 84 CVPSRWKCDGDPDCEDGSDESPEQC 108
Score = 43.6 bits (98), Expect = 0.004
Identities = 30/99 (30%), Positives = 38/99 (38%), Gaps = 22/99 (22%)
Query: 1097 CDGQQDCEDGRDEAEC-----GA----------------CGGDVRCADGTXXXXXXXXXX 1135
C+GQ DC DG DE +C GA C D C+D +
Sbjct: 173 CNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQ 232
Query: 1136 XXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
+ +C G CI ++ CDG P C DGSDE
Sbjct: 233 PVIHTKCPASE-IQCGSGECIHKKWRCDGDPDCKDGSDE 270
Score = 37.5 bits (83), Expect = 0.29
Identities = 28/99 (28%), Positives = 34/99 (34%), Gaps = 15/99 (15%)
Query: 1096 QCDGQQDCEDGRDEAECGA--CGGD-VRCADGTXXXXXXXXXXXXXXXXXXXX------- 1145
+CDG DC+DG DE C + C D C DG+
Sbjct: 257 RCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVN 316
Query: 1146 -----DAFRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F+C G CI VC+ C D SDE C
Sbjct: 317 QCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKEC 355
Score = 33.1 bits (72), Expect = 6.2
Identities = 12/19 (63%), Positives = 14/19 (73%)
Query: 1094 SRQCDGQQDCEDGRDEAEC 1112
SRQC+G +DC DG DE C
Sbjct: 294 SRQCNGIRDCVDGSDEVNC 312
>D16493-1|BAA03945.1| 873|Homo sapiens very low density lipoprotein
receptor protein.
Length = 873
Score = 178 bits (434), Expect = 8e-44
Identities = 100/289 (34%), Positives = 159/289 (55%), Gaps = 15/289 (5%)
Query: 13 IAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAID 72
+ + L A+D + W+D + I + ++ G K++ + + P IA+D
Sbjct: 464 LVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDK-VGRHVKMI-DNVYNPAAIAVD 521
Query: 73 WYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKI 132
W +YWTD + I V ++ RK LF S++ +IAV P G ++W+DWGE KI
Sbjct: 522 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKI 581
Query: 133 ERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVK 192
E+AGMNG R+ +V +I WPNGIT+D S +YW+D+KL + +D NG+ R+ V+K
Sbjct: 582 EKAGMNG--FDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLK 639
Query: 193 G--GLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESR 250
L +P ALT D++YW D +N ++Y + G ++ L+ + DI VY E
Sbjct: 640 SLEFLAHPLALTIFEDRVYWIDGENEAVYGAN-KFTGSELATLVNNLNDAQDIIVYHELV 698
Query: 251 QIISAEDYPCKKN--NAGCSHLCLLSPD----PPGYNCACPTGVKLREN 293
Q S +++ C+++ N GC +LCL +P P Y C+CP+G + EN
Sbjct: 699 Q-PSGKNW-CEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEEN 745
Score = 173 bits (420), Expect = 4e-42
Identities = 98/359 (27%), Positives = 176/359 (49%), Gaps = 16/359 (4%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTC--VEPEAFLVYSRKNIIGRLSIKNEYNDA 630
G CS +C N Y C C G ++ C V E L+++ + I ++ + E +
Sbjct: 404 GICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGL--ERKEY 461
Query: 631 VIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVE--KIVEWLGLVEGLAID 688
+ ++ L+ AL ++ KL+W+D K I S++ K+++ + +A+D
Sbjct: 462 IQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVD 521
Query: 689 WSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS-I 747
W + IYWTD ++ I V+ LDG+ R+ + L++P SI +DP G++YWS+ G + I
Sbjct: 522 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKI 581
Query: 748 KRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNI 806
++A M+G + + + + +D + +YW ++ LNG R+ + ++
Sbjct: 582 EKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSL 641
Query: 807 PM---PYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHR-AKSM 862
P AL +F D VYW D + A K GS ++ +L+ D+ +YH +
Sbjct: 642 EFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPS 701
Query: 863 GSNQC--GVDNGGCSHLCLPTP--GDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQ 917
G N C ++NGGC +LCLP P D Y C+CP+ Y + ++ C + +++
Sbjct: 702 GKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSE 760
Score = 169 bits (410), Expect = 7e-41
Identities = 105/365 (28%), Positives = 174/365 (47%), Gaps = 19/365 (5%)
Query: 262 KNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDS 321
+N CS +C+ GY C C G ++ + + L+ R I KI L+
Sbjct: 401 QNPGICSQICINLKG--GYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLER 458
Query: 322 PDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGV--P 379
+ Y ++ L+ T+ +D D + ++WAD K I A +D V V P
Sbjct: 459 KE---YIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNP 515
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDW 439
+IA+D + + IYWTD TI+VA LDG+ K + +++L +P +IA+ +G+++WSDW
Sbjct: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
Query: 440 NEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTER 499
E KIE+A ++G R L++ + WPN I LD + ++LYW D++ H + +++G +R
Sbjct: 576 GE-PAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDR 634
Query: 500 K-ELHSNDII-HIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAF 557
+ L S + + H + + NK TG + +V + + + +
Sbjct: 635 RIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVY 694
Query: 558 -RLGAPLGWNPCADD--NGGCSHLCFNRPD------DYICGCPLGLELTADKKTCVEPEA 608
L P G N C +D NGGC +LC P Y C CP G + + + C
Sbjct: 695 HELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTAT 754
Query: 609 FLVYS 613
+ YS
Sbjct: 755 TVTYS 759
Score = 83.8 bits (198), Expect = 3e-15
Identities = 71/294 (24%), Positives = 129/294 (43%), Gaps = 14/294 (4%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGR--LSI 623
N C +NGGCSH+C + Y C C G EL D+KTC + + I + +++
Sbjct: 358 NECLVNNGGCSHICKDLVIGYECDCAAGFEL-IDRKTCGDIDE---CQNPGICSQICINL 413
Query: 624 KNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVE 683
K Y + + + V G + + + I + + ++VE L
Sbjct: 414 KGGYKCECSRGYQMDLATGVCKAV-GKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTV 472
Query: 684 GLAIDWSGQNIYWTDTTTQRIEVSRLDGS-SRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
L D + Q ++W D + + I + +D R + + P +I +D +YW++
Sbjct: 473 ALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDA 532
Query: 743 GSKSIKRAAMDGSSVS-VFMEQVGRVHALAIDYERRAIYWAAL-DPPVVEFAFLNGTGRQ 800
SK+I A +DG+ +F + ++A+D +YW+ +P +E A +NG R+
Sbjct: 533 ASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRR 592
Query: 801 TL--AD-NIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYIS 851
L AD P L L +YW D + +G +R+ + K L++++
Sbjct: 593 PLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSV-DLNGQDRRIVLKSLEFLA 645
Score = 74.9 bits (176), Expect = 2e-12
Identities = 69/252 (27%), Positives = 108/252 (42%), Gaps = 16/252 (6%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISL 319
C NN GCSH+C GY C C G +L + + D Q + +Q K
Sbjct: 360 CLVNNGGCSHIC--KDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGY 417
Query: 320 DSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGVP 379
Y + DL + + I+ + I K L+ + +V
Sbjct: 418 KCECSRGYQM---DLATGVCKAVGKEPSLIFTN---RRDIRKIGLERKEYIQLVEQLRNT 471
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLD---GSYEKVIIHTELYDPRAIALHLTAGWMFW 436
++ D ++K++W D I A +D G + K+I +Y+P AIA+ ++W
Sbjct: 472 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNPAAIAVDWVYKTIYW 529
Query: 437 SDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGD-ARTHKIEVCNMD 495
+D K I A LDG+ R L + L P SIA+D ++ +YW D KIE M+
Sbjct: 530 TDAASK--TISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMN 587
Query: 496 GTERKELHSNDI 507
G +R+ L + DI
Sbjct: 588 GFDRRPLVTADI 599
Score = 61.7 bits (143), Expect = 2e-08
Identities = 59/256 (23%), Positives = 105/256 (41%), Gaps = 20/256 (7%)
Query: 846 DLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNIT 905
+ D + +L R ++C + G CS +C+ G Y+C C Y+++
Sbjct: 379 ECDCAAGFELIDRKTCGDIDECQ-NPGICSQICINLKGG----YKCECSRGYQMDLATGV 433
Query: 906 CSE--PEEFLLFAQKNAVGRIMVANGECNDAYIPLTG-LKNVRAIEYDPVEKQLYWMDDD 962
C E L+F + + +I + E YI L L+N A++ D ++L+W D
Sbjct: 434 CKAVGKEPSLIFTNRRDIRKIGLERKE----YIQLVEQLRNTVALDADIAAQKLFWADLS 489
Query: 963 SHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNN 1022
+I S + P + +D + +T+YWT A +I+ ++D
Sbjct: 490 QKAI----FSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLD-G 544
Query: 1023 SSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGA-IMRANVDGTGRVELARADN--ATA 1079
+ + D P +A ++ W+D G A I +A ++G R L AD
Sbjct: 545 TKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNG 604
Query: 1080 LALDQSAGTVYWAVSR 1095
+ LD +YW S+
Sbjct: 605 ITLDLIKSRLYWLDSK 620
Score = 55.2 bits (127), Expect = 1e-06
Identities = 54/232 (23%), Positives = 92/232 (39%), Gaps = 20/232 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL--FAQKNAVG 922
N+C V+NGGCSH+C D+ Y C C A + L D TC + +E + +
Sbjct: 358 NECLVNNGGCSHIC----KDLVIGYECDCAAGFEL-IDRKTCGDIDECQNPGICSQICIN 412
Query: 923 RIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXX 982
EC+ Y +A+ +P L + + IR++ +
Sbjct: 413 LKGGYKCECSRGYQMDLATGVCKAVGKEP---SLIF--TNRRDIRKIGLERKEYIQLVEQ 467
Query: 983 XXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFH 1042
L D+ + ++W + +I + SID+ V + + P +A
Sbjct: 468 LRNTVALD------ADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVD 521
Query: 1043 QTKRYLIWNDVGRGAIMRANVDGTGRVELARAD--NATALALDQSAGTVYWA 1092
+ + W D I A +DGT R L +D ++A+D +G VYW+
Sbjct: 522 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWS 573
Score = 53.2 bits (122), Expect = 5e-06
Identities = 32/90 (35%), Positives = 42/90 (46%), Gaps = 29/90 (32%)
Query: 1093 VSRQCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDE 1152
VS +CDG+ DC+ G DE CG ++ C+ D F C
Sbjct: 130 VSWRCDGENDCDSGEDEENCG----NITCSP----------------------DEFTCSS 163
Query: 1153 GLCIAARFVCDGRPQCADGSDE---APAAC 1179
G CI+ FVC+G+ C+DGSDE AP C
Sbjct: 164 GRCISRNFVCNGQDDCSDGSDELDCAPPTC 193
Score = 52.4 bits (120), Expect = 9e-06
Identities = 28/85 (32%), Positives = 37/85 (43%), Gaps = 9/85 (10%)
Query: 1096 QCDGQQ-DCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGL 1154
+C+ Q C +GR C GD C DG+ F C+ G
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESD--------FVCNNGQ 83
Query: 1155 CIAARFVCDGRPQCADGSDEAPAAC 1179
C+ +R+ CDG P C DGSDE+P C
Sbjct: 84 CVPSRWKCDGDPDCEDGSDESPEQC 108
Score = 43.6 bits (98), Expect = 0.004
Identities = 30/99 (30%), Positives = 38/99 (38%), Gaps = 22/99 (22%)
Query: 1097 CDGQQDCEDGRDEAEC-----GA----------------CGGDVRCADGTXXXXXXXXXX 1135
C+GQ DC DG DE +C GA C D C+D +
Sbjct: 173 CNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQ 232
Query: 1136 XXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
+ +C G CI ++ CDG P C DGSDE
Sbjct: 233 PVIHTKCPASE-IQCGSGECIHKKWRCDGDPDCKDGSDE 270
Score = 37.5 bits (83), Expect = 0.29
Identities = 28/99 (28%), Positives = 34/99 (34%), Gaps = 15/99 (15%)
Query: 1096 QCDGQQDCEDGRDEAECGA--CGGD-VRCADGTXXXXXXXXXXXXXXXXXXXX------- 1145
+CDG DC+DG DE C + C D C DG+
Sbjct: 257 RCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVN 316
Query: 1146 -----DAFRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F+C G CI VC+ C D SDE C
Sbjct: 317 QCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKEC 355
Score = 33.1 bits (72), Expect = 6.2
Identities = 12/19 (63%), Positives = 14/19 (73%)
Query: 1094 SRQCDGQQDCEDGRDEAEC 1112
SRQC+G +DC DG DE C
Sbjct: 294 SRQCNGIRDCVDGSDEVNC 312
>DQ067198-1|AAY46157.1| 873|Homo sapiens very low density
lipoprotein receptor protein.
Length = 873
Score = 178 bits (434), Expect = 8e-44
Identities = 100/289 (34%), Positives = 159/289 (55%), Gaps = 15/289 (5%)
Query: 13 IAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAID 72
+ + L A+D + W+D + I + ++ G K++ + + P IA+D
Sbjct: 464 LVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDK-VGRHVKMI-DNVYNPAAIAVD 521
Query: 73 WYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKI 132
W +YWTD + I V ++ RK LF S++ +IAV P G ++W+DWGE KI
Sbjct: 522 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKI 581
Query: 133 ERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVK 192
E+AGMNG R+ +V +I WPNGIT+D S +YW+D+KL + +D NG+ R+ V+K
Sbjct: 582 EKAGMNG--FDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLK 639
Query: 193 G--GLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESR 250
L +P ALT D++YW D +N ++Y + G ++ L+ + DI VY E
Sbjct: 640 SLEFLAHPLALTIFEDRVYWIDGENEAVYGAN-KFTGSELATLVNNLNDAQDIIVYHELV 698
Query: 251 QIISAEDYPCKKN--NAGCSHLCLLSPD----PPGYNCACPTGVKLREN 293
Q S +++ C+++ N GC +LCL +P P Y C+CP+G + EN
Sbjct: 699 Q-PSGKNW-CEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEEN 745
Score = 173 bits (420), Expect = 4e-42
Identities = 98/359 (27%), Positives = 176/359 (49%), Gaps = 16/359 (4%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTC--VEPEAFLVYSRKNIIGRLSIKNEYNDA 630
G CS +C N Y C C G ++ C V E L+++ + I ++ + E +
Sbjct: 404 GICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGL--ERKEY 461
Query: 631 VIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVE--KIVEWLGLVEGLAID 688
+ ++ L+ AL ++ KL+W+D K I S++ K+++ + +A+D
Sbjct: 462 IQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVD 521
Query: 689 WSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS-I 747
W + IYWTD ++ I V+ LDG+ R+ + L++P SI +DP G++YWS+ G + I
Sbjct: 522 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKI 581
Query: 748 KRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNI 806
++A M+G + + + + +D + +YW ++ LNG R+ + ++
Sbjct: 582 EKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSL 641
Query: 807 PM---PYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHR-AKSM 862
P AL +F D VYW D + A K GS ++ +L+ D+ +YH +
Sbjct: 642 EFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPS 701
Query: 863 GSNQC--GVDNGGCSHLCLPTP--GDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQ 917
G N C ++NGGC +LCLP P D Y C+CP+ Y + ++ C + +++
Sbjct: 702 GKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSE 760
Score = 169 bits (410), Expect = 7e-41
Identities = 105/365 (28%), Positives = 174/365 (47%), Gaps = 19/365 (5%)
Query: 262 KNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDS 321
+N CS +C+ GY C C G ++ + + L+ R I KI L+
Sbjct: 401 QNPGICSQICINLKG--GYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLER 458
Query: 322 PDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGV--P 379
+ Y ++ L+ T+ +D D + ++WAD K I A +D V V P
Sbjct: 459 KE---YIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNP 515
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDW 439
+IA+D + + IYWTD TI+VA LDG+ K + +++L +P +IA+ +G+++WSDW
Sbjct: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
Query: 440 NEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTER 499
E KIE+A ++G R L++ + WPN I LD + ++LYW D++ H + +++G +R
Sbjct: 576 GE-PAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDR 634
Query: 500 K-ELHSNDII-HIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAF 557
+ L S + + H + + NK TG + +V + + + +
Sbjct: 635 RIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVY 694
Query: 558 -RLGAPLGWNPCADD--NGGCSHLCFNRPD------DYICGCPLGLELTADKKTCVEPEA 608
L P G N C +D NGGC +LC P Y C CP G + + + C
Sbjct: 695 HELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTAT 754
Query: 609 FLVYS 613
+ YS
Sbjct: 755 TVTYS 759
Score = 83.8 bits (198), Expect = 3e-15
Identities = 71/294 (24%), Positives = 129/294 (43%), Gaps = 14/294 (4%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGR--LSI 623
N C +NGGCSH+C + Y C C G EL D+KTC + + I + +++
Sbjct: 358 NECLVNNGGCSHICKDLVIGYECDCAAGFEL-IDRKTCGDIDE---CQNPGICSQICINL 413
Query: 624 KNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVE 683
K Y + + + V G + + + I + + ++VE L
Sbjct: 414 KGGYKCECSRGYQMDLATGVCKAV-GKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTV 472
Query: 684 GLAIDWSGQNIYWTDTTTQRIEVSRLDGS-SRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
L D + Q ++W D + + I + +D R + + P +I +D +YW++
Sbjct: 473 ALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDA 532
Query: 743 GSKSIKRAAMDGSSVS-VFMEQVGRVHALAIDYERRAIYWAAL-DPPVVEFAFLNGTGRQ 800
SK+I A +DG+ +F + ++A+D +YW+ +P +E A +NG R+
Sbjct: 533 ASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRR 592
Query: 801 TL--AD-NIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYIS 851
L AD P L L +YW D + +G +R+ + K L++++
Sbjct: 593 PLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSV-DLNGQDRRIVLKSLEFLA 645
Score = 74.9 bits (176), Expect = 2e-12
Identities = 69/252 (27%), Positives = 108/252 (42%), Gaps = 16/252 (6%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISL 319
C NN GCSH+C GY C C G +L + + D Q + +Q K
Sbjct: 360 CLVNNGGCSHIC--KDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGY 417
Query: 320 DSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGVP 379
Y + DL + + I+ + I K L+ + +V
Sbjct: 418 KCECSRGYQM---DLATGVCKAVGKEPSLIFTN---RRDIRKIGLERKEYIQLVEQLRNT 471
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLD---GSYEKVIIHTELYDPRAIALHLTAGWMFW 436
++ D ++K++W D I A +D G + K+I +Y+P AIA+ ++W
Sbjct: 472 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNPAAIAVDWVYKTIYW 529
Query: 437 SDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGD-ARTHKIEVCNMD 495
+D K I A LDG+ R L + L P SIA+D ++ +YW D KIE M+
Sbjct: 530 TDAASK--TISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMN 587
Query: 496 GTERKELHSNDI 507
G +R+ L + DI
Sbjct: 588 GFDRRPLVTADI 599
Score = 61.7 bits (143), Expect = 2e-08
Identities = 59/256 (23%), Positives = 105/256 (41%), Gaps = 20/256 (7%)
Query: 846 DLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNIT 905
+ D + +L R ++C + G CS +C+ G Y+C C Y+++
Sbjct: 379 ECDCAAGFELIDRKTCGDIDECQ-NPGICSQICINLKGG----YKCECSRGYQMDLATGV 433
Query: 906 CSE--PEEFLLFAQKNAVGRIMVANGECNDAYIPLTG-LKNVRAIEYDPVEKQLYWMDDD 962
C E L+F + + +I + E YI L L+N A++ D ++L+W D
Sbjct: 434 CKAVGKEPSLIFTNRRDIRKIGLERKE----YIQLVEQLRNTVALDADIAAQKLFWADLS 489
Query: 963 SHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNN 1022
+I S + P + +D + +T+YWT A +I+ ++D
Sbjct: 490 QKAI----FSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLD-G 544
Query: 1023 SSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGA-IMRANVDGTGRVELARADN--ATA 1079
+ + D P +A ++ W+D G A I +A ++G R L AD
Sbjct: 545 TKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNG 604
Query: 1080 LALDQSAGTVYWAVSR 1095
+ LD +YW S+
Sbjct: 605 ITLDLIKSRLYWLDSK 620
Score = 55.2 bits (127), Expect = 1e-06
Identities = 54/232 (23%), Positives = 92/232 (39%), Gaps = 20/232 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL--FAQKNAVG 922
N+C V+NGGCSH+C D+ Y C C A + L D TC + +E + +
Sbjct: 358 NECLVNNGGCSHIC----KDLVIGYECDCAAGFEL-IDRKTCGDIDECQNPGICSQICIN 412
Query: 923 RIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXX 982
EC+ Y +A+ +P L + + IR++ +
Sbjct: 413 LKGGYKCECSRGYQMDLATGVCKAVGKEP---SLIF--TNRRDIRKIGLERKEYIQLVEQ 467
Query: 983 XXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFH 1042
L D+ + ++W + +I + SID+ V + + P +A
Sbjct: 468 LRNTVALD------ADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVD 521
Query: 1043 QTKRYLIWNDVGRGAIMRANVDGTGRVELARAD--NATALALDQSAGTVYWA 1092
+ + W D I A +DGT R L +D ++A+D +G VYW+
Sbjct: 522 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWS 573
Score = 53.2 bits (122), Expect = 5e-06
Identities = 32/90 (35%), Positives = 42/90 (46%), Gaps = 29/90 (32%)
Query: 1093 VSRQCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDE 1152
VS +CDG+ DC+ G DE CG ++ C+ D F C
Sbjct: 130 VSWRCDGENDCDSGEDEENCG----NITCSP----------------------DEFTCSS 163
Query: 1153 GLCIAARFVCDGRPQCADGSDE---APAAC 1179
G CI+ FVC+G+ C+DGSDE AP C
Sbjct: 164 GRCISRNFVCNGQDDCSDGSDELDCAPPTC 193
Score = 52.4 bits (120), Expect = 9e-06
Identities = 28/85 (32%), Positives = 37/85 (43%), Gaps = 9/85 (10%)
Query: 1096 QCDGQQ-DCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGL 1154
+C+ Q C +GR C GD C DG+ F C+ G
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESD--------FVCNNGQ 83
Query: 1155 CIAARFVCDGRPQCADGSDEAPAAC 1179
C+ +R+ CDG P C DGSDE+P C
Sbjct: 84 CVPSRWKCDGDPDCEDGSDESPEQC 108
Score = 43.6 bits (98), Expect = 0.004
Identities = 30/99 (30%), Positives = 38/99 (38%), Gaps = 22/99 (22%)
Query: 1097 CDGQQDCEDGRDEAEC-----GA----------------CGGDVRCADGTXXXXXXXXXX 1135
C+GQ DC DG DE +C GA C D C+D +
Sbjct: 173 CNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQ 232
Query: 1136 XXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
+ +C G CI ++ CDG P C DGSDE
Sbjct: 233 PVIHTKCPASE-IQCGSGECIHKKWRCDGDPDCKDGSDE 270
Score = 37.5 bits (83), Expect = 0.29
Identities = 28/99 (28%), Positives = 34/99 (34%), Gaps = 15/99 (15%)
Query: 1096 QCDGQQDCEDGRDEAECGA--CGGD-VRCADGTXXXXXXXXXXXXXXXXXXXX------- 1145
+CDG DC+DG DE C + C D C DG+
Sbjct: 257 RCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVN 316
Query: 1146 -----DAFRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F+C G CI VC+ C D SDE C
Sbjct: 317 QCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKEC 355
Score = 33.1 bits (72), Expect = 6.2
Identities = 12/19 (63%), Positives = 14/19 (73%)
Query: 1094 SRQCDGQQDCEDGRDEAEC 1112
SRQC+G +DC DG DE C
Sbjct: 294 SRQCNGIRDCVDGSDEVNC 312
>AL606760-3|CAI18909.1| 700|Homo sapiens low density lipoprotein
receptor-related protein 8, apolipoprotein e receptor
protein.
Length = 700
Score = 178 bits (434), Expect = 8e-44
Identities = 98/277 (35%), Positives = 151/277 (54%), Gaps = 11/277 (3%)
Query: 17 LEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKI-VSEGLVTPTGIAIDWYT 75
L+ A+D N I W D I ++ ++ ++ + E L +P G+A+DW
Sbjct: 320 LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVH 379
Query: 76 DKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERA 135
+YWTD I V ++ R+ LF + RAIAV P G M+W+DWG+ KIE++
Sbjct: 380 KHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKS 439
Query: 136 GMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVKGG- 194
G+NG R+ +V DNI WPNGIT+D + +YWVD+KL + IDF+G RK ++
Sbjct: 440 GLNG--VDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTD 497
Query: 195 -LVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESRQII 253
L +PF + DK++WTD +N +I++ + NG +I L ++ P DI ++ E +Q
Sbjct: 498 FLSHPFGIAVFEDKVFWTDLENEAIFSAN-RLNGLEISILAENLNNPHDIVIFHELKQPR 556
Query: 254 SAEDYPCK-KNNAGCSHLCLLSPD----PPGYNCACP 285
+ + + N GC +LCL +P P Y CACP
Sbjct: 557 APDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACP 593
Score = 165 bits (401), Expect = 8e-40
Identities = 111/365 (30%), Positives = 175/365 (47%), Gaps = 31/365 (8%)
Query: 260 CKKNNAGCSHLCLLSPDPPGY-NCACPTGVK---LRENSSTTCYDSPQMLLVVAQRSTIS 315
CK +A CS +C+ + GY C C G + L +N SP L+ R +
Sbjct: 251 CKDPDA-CSQICV---NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPS--LIFTNRHEVR 304
Query: 316 KISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGS----DQSV 371
+I L +++ +P+ LK + +D + T IYW D + I A +D + +Q V
Sbjct: 305 RIDLVKRNYSRL-IPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEV 361
Query: 372 VVRSS-GVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLT 430
++ P+ +A+D + + IYWTD TI+VA +DG + + L +PRAIA+
Sbjct: 362 LIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPL 421
Query: 431 AGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIE 490
G+M+WSDW + + KIE++ L+G R L+S+ + WPN I LD ++ +LYW D++ H++
Sbjct: 422 RGFMYWSDWGD-QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS 480
Query: 491 VCNMDGTERKEL-HSNDII-HIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQM 548
+ G RK L S D + H FG ++ + N+ GL+ + E +
Sbjct: 481 SIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL 540
Query: 549 ANMMGVKAF-RLGAPLGWNPC---ADDNGGCSHLCFNRPD------DYICGCPLGLELTA 598
N + F L P + C NGGC +LC P Y C CP + L
Sbjct: 541 NNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGP 600
Query: 599 DKKTC 603
D K C
Sbjct: 601 DMKRC 605
Score = 163 bits (397), Expect = 3e-39
Identities = 100/355 (28%), Positives = 175/355 (49%), Gaps = 21/355 (5%)
Query: 571 DNGGCSHLCFNRPDDYICGCPLGLE---LTADKKTCVEPEAFLVYSRKNIIGRLSIKNEY 627
D CS +C N + C C G E LT + K L+++ ++ + R+ +
Sbjct: 253 DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRN 312
Query: 628 NDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEK-----IVEWLGLV 682
+IP+ LK V AL + V+ +++YW D + I ++ ++ K I E L
Sbjct: 313 YSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSP 370
Query: 683 EGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
EGLA+DW ++IYWTD+ + I V+ +DG RR + + L +P++I +DP +G+MYWS+
Sbjct: 371 EGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW 430
Query: 743 GSKS-IKRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQ 800
G ++ I+++ ++G ++ + + + + +D + +YW + +G R+
Sbjct: 431 GDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRK 490
Query: 801 TL---ADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYH 857
TL D + P+ +A+F D V+W D I A + +G + ++L+ D+ ++H
Sbjct: 491 TLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFH 550
Query: 858 RAKS-MGSNQCGVD---NGGCSHLCLPTP--GDVRTDYRCACPAHYRLNKDNITC 906
K + C + NGGC +LCLP P Y CACP L D C
Sbjct: 551 ELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 605
Score = 108 bits (260), Expect = 1e-22
Identities = 79/301 (26%), Positives = 141/301 (46%), Gaps = 12/301 (3%)
Query: 560 GAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIG 619
G G N C +NGGCSH+C + + C CP G +L D+KTC + + + I
Sbjct: 203 GCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGDIDECKDPDACSQI- 260
Query: 620 RLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWL 679
++ K + P ++ ++ +G + + R + +++ L
Sbjct: 261 CVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPML 320
Query: 680 GLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSS----RRAIIWQGLKKPKSIVLDPKKG 735
V L ++ + IYW D + ++I + +D +S + +I + L P+ + +D
Sbjct: 321 KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHK 380
Query: 736 YMYWSELGSKSIKRAAMDGS-SVSVFMEQVGRVHALAIDYERRAIYWAAL-DPPVVEFAF 793
++YW++ G+K+I A +DG ++F + A+A+D R +YW+ D +E +
Sbjct: 381 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSG 440
Query: 794 LNGTGRQTL-ADNIPMP--YALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYI 850
LNG RQTL +DNI P L L + +YW D Q+ G NRK++ D++
Sbjct: 441 LNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSI-DFSGGNRKTLISSTDFL 499
Query: 851 S 851
S
Sbjct: 500 S 500
Score = 73.3 bits (172), Expect = 5e-12
Identities = 62/253 (24%), Positives = 109/253 (43%), Gaps = 14/253 (5%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISL 319
C NN GCSH+C + G+ C CP G +L + + D + +Q K
Sbjct: 211 CLHNNGGCSHIC--TDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 268
Query: 320 DSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGVP 379
+ Y + L L + I+ + I + + S ++++
Sbjct: 269 KCECYPGYEMDL--LTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVAL 326
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLDGS----YEKVIIHTELYDPRAIALHLTAGWMF 435
D ++ + +IYW D I A +D + ++V+I +L+ P +A+ ++
Sbjct: 327 D---VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 383
Query: 436 WSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGD-ARTHKIEVCNM 494
W+D K I A +DG R L S L+ P +IA+D + +YW D KIE +
Sbjct: 384 WTDSGNK--TISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGL 441
Query: 495 DGTERKELHSNDI 507
+G +R+ L S++I
Sbjct: 442 NGVDRQTLVSDNI 454
Score = 57.2 bits (132), Expect = 3e-07
Identities = 60/240 (25%), Positives = 92/240 (38%), Gaps = 28/240 (11%)
Query: 863 GSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVG 922
G N+C +NGGCSH+C D++ + C CPA ++L D TC + +E +A
Sbjct: 207 GLNECLHNNGGCSHICT----DLKIGFECTCPAGFQL-LDQKTCGDIDE---CKDPDACS 258
Query: 923 RIMV-----ANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXX 977
+I V EC Y KN +A K + + H +RR+ +
Sbjct: 259 QICVNYKGYFKCECYPGYEMDLLTKNCKA----AAGKSPSLIFTNRHEVRRIDLVKRNYS 314
Query: 978 XXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNS---STGVIVRGDRM 1034
L ++V +YW I + +D S V++
Sbjct: 315 RLIPMLKNVVALD------VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH 368
Query: 1035 LPRHLAFHQTKRYLIWNDVGRGAIMRANVDGTGRVEL--ARADNATALALDQSAGTVYWA 1092
P LA +++ W D G I A VDG R L A+A+D G +YW+
Sbjct: 369 SPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWS 428
Score = 56.0 bits (129), Expect = 8e-07
Identities = 54/235 (22%), Positives = 101/235 (42%), Gaps = 21/235 (8%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYR---LNKDNITCSEPEEFLLFAQKNAVGRIMV 926
D CS +C+ G ++C C Y L K+ + L+F ++ V RI +
Sbjct: 253 DPDACSQICVNYKGY----FKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDL 308
Query: 927 ANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXX--XXXXXX 984
+ IP+ LKNV A++ + ++YW D S R++ +Y
Sbjct: 309 VKRNYS-RLIPM--LKNVVALDVEVATNRIYWCD---LSYRKIYSAYMDKASDPKEQEVL 362
Query: 985 XXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQT 1044
L P + +D + + +YWT + +I+ ++D + R + PR +A
Sbjct: 363 IDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSR-NLSEPRAIAVDPL 421
Query: 1045 KRYLIWNDVG-RGAIMRANVDGTGRVELARADN---ATALALDQSAGTVYWAVSR 1095
+ ++ W+D G + I ++ ++G R L +DN + LD + +YW S+
Sbjct: 422 RGFMYWSDWGDQAKIEKSGLNGVDRQTLV-SDNIEWPNGITLDLLSQRLYWVDSK 475
Score = 47.2 bits (107), Expect = 4e-04
Identities = 18/32 (56%), Positives = 21/32 (65%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F CD G CI R+ CDG +C DGSDE+ A C
Sbjct: 91 FTCDNGHCIHERWKCDGEEECPDGSDESEATC 122
Score = 43.2 bits (97), Expect = 0.006
Identities = 28/82 (34%), Positives = 35/82 (42%), Gaps = 24/82 (29%)
Query: 1094 SRQCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEG 1153
S +CDG++DCE G DEA C G R D F+C +G
Sbjct: 145 SWRCDGEKDCEGGADEAGCATSLGTCR------------------------GDEFQCGDG 180
Query: 1154 LCIAARFVCDGRPQCADGSDEA 1175
C+ A C+ C DGSDEA
Sbjct: 181 TCVLAIKHCNQEQDCPDGSDEA 202
>AL450467-4|CAH72455.1| 845|Homo sapiens very low density
lipoprotein receptor protein.
Length = 845
Score = 178 bits (434), Expect = 8e-44
Identities = 100/289 (34%), Positives = 159/289 (55%), Gaps = 15/289 (5%)
Query: 13 IAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAID 72
+ + L A+D + W+D + I + ++ G K++ + + P IA+D
Sbjct: 464 LVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDK-VGRHVKMI-DNVYNPAAIAVD 521
Query: 73 WYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKI 132
W +YWTD + I V ++ RK LF S++ +IAV P G ++W+DWGE KI
Sbjct: 522 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKI 581
Query: 133 ERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVK 192
E+AGMNG R+ +V +I WPNGIT+D S +YW+D+KL + +D NG+ R+ V+K
Sbjct: 582 EKAGMNG--FDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLK 639
Query: 193 G--GLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESR 250
L +P ALT D++YW D +N ++Y + G ++ L+ + DI VY E
Sbjct: 640 SLEFLAHPLALTIFEDRVYWIDGENEAVYGAN-KFTGSELATLVNNLNDAQDIIVYHELV 698
Query: 251 QIISAEDYPCKKN--NAGCSHLCLLSPD----PPGYNCACPTGVKLREN 293
Q S +++ C+++ N GC +LCL +P P Y C+CP+G + EN
Sbjct: 699 Q-PSGKNW-CEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEEN 745
Score = 172 bits (419), Expect = 6e-42
Identities = 98/348 (28%), Positives = 172/348 (49%), Gaps = 16/348 (4%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTC--VEPEAFLVYSRKNIIGRLSIKNEYNDA 630
G CS +C N Y C C G ++ C V E L+++ + I ++ + E +
Sbjct: 404 GICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGL--ERKEY 461
Query: 631 VIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVE--KIVEWLGLVEGLAID 688
+ ++ L+ AL ++ KL+W+D K I S++ K+++ + +A+D
Sbjct: 462 IQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVD 521
Query: 689 WSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS-I 747
W + IYWTD ++ I V+ LDG+ R+ + L++P SI +DP G++YWS+ G + I
Sbjct: 522 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKI 581
Query: 748 KRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNI 806
++A M+G + + + + +D + +YW ++ LNG R+ + ++
Sbjct: 582 EKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSL 641
Query: 807 PM---PYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHR-AKSM 862
P AL +F D VYW D + A K GS ++ +L+ D+ +YH +
Sbjct: 642 EFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPS 701
Query: 863 GSNQC--GVDNGGCSHLCLPTP--GDVRTDYRCACPAHYRLNKDNITC 906
G N C ++NGGC +LCLP P D Y C+CP+ Y + ++ C
Sbjct: 702 GKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749
Score = 166 bits (404), Expect = 4e-40
Identities = 103/355 (29%), Positives = 171/355 (48%), Gaps = 19/355 (5%)
Query: 262 KNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDS 321
+N CS +C+ GY C C G ++ + + L+ R I KI L+
Sbjct: 401 QNPGICSQICINLKG--GYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLER 458
Query: 322 PDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGV--P 379
+ Y ++ L+ T+ +D D + ++WAD K I A +D V V P
Sbjct: 459 KE---YIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNP 515
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDW 439
+IA+D + + IYWTD TI+VA LDG+ K + +++L +P +IA+ +G+++WSDW
Sbjct: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
Query: 440 NEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTER 499
E KIE+A ++G R L++ + WPN I LD + ++LYW D++ H + +++G +R
Sbjct: 576 GE-PAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDR 634
Query: 500 K-ELHSNDII-HIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAF 557
+ L S + + H + + NK TG + +V + + + +
Sbjct: 635 RIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVY 694
Query: 558 -RLGAPLGWNPCADD--NGGCSHLCFNRPD------DYICGCPLGLELTADKKTC 603
L P G N C +D NGGC +LC P Y C CP G + + + C
Sbjct: 695 HELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749
Score = 83.8 bits (198), Expect = 3e-15
Identities = 71/294 (24%), Positives = 129/294 (43%), Gaps = 14/294 (4%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGR--LSI 623
N C +NGGCSH+C + Y C C G EL D+KTC + + I + +++
Sbjct: 358 NECLVNNGGCSHICKDLVIGYECDCAAGFEL-IDRKTCGDIDE---CQNPGICSQICINL 413
Query: 624 KNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVE 683
K Y + + + V G + + + I + + ++VE L
Sbjct: 414 KGGYKCECSRGYQMDLATGVCKAV-GKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTV 472
Query: 684 GLAIDWSGQNIYWTDTTTQRIEVSRLDGS-SRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
L D + Q ++W D + + I + +D R + + P +I +D +YW++
Sbjct: 473 ALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDA 532
Query: 743 GSKSIKRAAMDGSSVS-VFMEQVGRVHALAIDYERRAIYWAAL-DPPVVEFAFLNGTGRQ 800
SK+I A +DG+ +F + ++A+D +YW+ +P +E A +NG R+
Sbjct: 533 ASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRR 592
Query: 801 TL--AD-NIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYIS 851
L AD P L L +YW D + +G +R+ + K L++++
Sbjct: 593 PLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSV-DLNGQDRRIVLKSLEFLA 645
Score = 74.9 bits (176), Expect = 2e-12
Identities = 69/252 (27%), Positives = 108/252 (42%), Gaps = 16/252 (6%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISL 319
C NN GCSH+C GY C C G +L + + D Q + +Q K
Sbjct: 360 CLVNNGGCSHIC--KDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGY 417
Query: 320 DSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGVP 379
Y + DL + + I+ + I K L+ + +V
Sbjct: 418 KCECSRGYQM---DLATGVCKAVGKEPSLIFTN---RRDIRKIGLERKEYIQLVEQLRNT 471
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLD---GSYEKVIIHTELYDPRAIALHLTAGWMFW 436
++ D ++K++W D I A +D G + K+I +Y+P AIA+ ++W
Sbjct: 472 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNPAAIAVDWVYKTIYW 529
Query: 437 SDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGD-ARTHKIEVCNMD 495
+D K I A LDG+ R L + L P SIA+D ++ +YW D KIE M+
Sbjct: 530 TDAASK--TISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMN 587
Query: 496 GTERKELHSNDI 507
G +R+ L + DI
Sbjct: 588 GFDRRPLVTADI 599
Score = 61.7 bits (143), Expect = 2e-08
Identities = 59/256 (23%), Positives = 105/256 (41%), Gaps = 20/256 (7%)
Query: 846 DLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNIT 905
+ D + +L R ++C + G CS +C+ G Y+C C Y+++
Sbjct: 379 ECDCAAGFELIDRKTCGDIDECQ-NPGICSQICINLKGG----YKCECSRGYQMDLATGV 433
Query: 906 CSE--PEEFLLFAQKNAVGRIMVANGECNDAYIPLTG-LKNVRAIEYDPVEKQLYWMDDD 962
C E L+F + + +I + E YI L L+N A++ D ++L+W D
Sbjct: 434 CKAVGKEPSLIFTNRRDIRKIGLERKE----YIQLVEQLRNTVALDADIAAQKLFWADLS 489
Query: 963 SHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNN 1022
+I S + P + +D + +T+YWT A +I+ ++D
Sbjct: 490 QKAI----FSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLD-G 544
Query: 1023 SSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGA-IMRANVDGTGRVELARADN--ATA 1079
+ + D P +A ++ W+D G A I +A ++G R L AD
Sbjct: 545 TKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNG 604
Query: 1080 LALDQSAGTVYWAVSR 1095
+ LD +YW S+
Sbjct: 605 ITLDLIKSRLYWLDSK 620
Score = 55.2 bits (127), Expect = 1e-06
Identities = 54/232 (23%), Positives = 92/232 (39%), Gaps = 20/232 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL--FAQKNAVG 922
N+C V+NGGCSH+C D+ Y C C A + L D TC + +E + +
Sbjct: 358 NECLVNNGGCSHIC----KDLVIGYECDCAAGFEL-IDRKTCGDIDECQNPGICSQICIN 412
Query: 923 RIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXX 982
EC+ Y +A+ +P L + + IR++ +
Sbjct: 413 LKGGYKCECSRGYQMDLATGVCKAVGKEP---SLIF--TNRRDIRKIGLERKEYIQLVEQ 467
Query: 983 XXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFH 1042
L D+ + ++W + +I + SID+ V + + P +A
Sbjct: 468 LRNTVALD------ADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVD 521
Query: 1043 QTKRYLIWNDVGRGAIMRANVDGTGRVELARAD--NATALALDQSAGTVYWA 1092
+ + W D I A +DGT R L +D ++A+D +G VYW+
Sbjct: 522 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWS 573
Score = 53.2 bits (122), Expect = 5e-06
Identities = 32/90 (35%), Positives = 42/90 (46%), Gaps = 29/90 (32%)
Query: 1093 VSRQCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDE 1152
VS +CDG+ DC+ G DE CG ++ C+ D F C
Sbjct: 130 VSWRCDGENDCDSGEDEENCG----NITCSP----------------------DEFTCSS 163
Query: 1153 GLCIAARFVCDGRPQCADGSDE---APAAC 1179
G CI+ FVC+G+ C+DGSDE AP C
Sbjct: 164 GRCISRNFVCNGQDDCSDGSDELDCAPPTC 193
Score = 52.4 bits (120), Expect = 9e-06
Identities = 28/85 (32%), Positives = 37/85 (43%), Gaps = 9/85 (10%)
Query: 1096 QCDGQQ-DCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGL 1154
+C+ Q C +GR C GD C DG+ F C+ G
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESD--------FVCNNGQ 83
Query: 1155 CIAARFVCDGRPQCADGSDEAPAAC 1179
C+ +R+ CDG P C DGSDE+P C
Sbjct: 84 CVPSRWKCDGDPDCEDGSDESPEQC 108
Score = 43.6 bits (98), Expect = 0.004
Identities = 30/99 (30%), Positives = 38/99 (38%), Gaps = 22/99 (22%)
Query: 1097 CDGQQDCEDGRDEAEC-----GA----------------CGGDVRCADGTXXXXXXXXXX 1135
C+GQ DC DG DE +C GA C D C+D +
Sbjct: 173 CNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQ 232
Query: 1136 XXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
+ +C G CI ++ CDG P C DGSDE
Sbjct: 233 PVIHTKCPASE-IQCGSGECIHKKWRCDGDPDCKDGSDE 270
Score = 37.5 bits (83), Expect = 0.29
Identities = 28/99 (28%), Positives = 34/99 (34%), Gaps = 15/99 (15%)
Query: 1096 QCDGQQDCEDGRDEAECGA--CGGD-VRCADGTXXXXXXXXXXXXXXXXXXXX------- 1145
+CDG DC+DG DE C + C D C DG+
Sbjct: 257 RCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVN 316
Query: 1146 -----DAFRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F+C G CI VC+ C D SDE C
Sbjct: 317 QCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKEC 355
Score = 33.1 bits (72), Expect = 6.2
Identities = 12/19 (63%), Positives = 14/19 (73%)
Query: 1094 SRQCDGQQDCEDGRDEAEC 1112
SRQC+G +DC DG DE C
Sbjct: 294 SRQCNGIRDCVDGSDEVNC 312
>AL450467-3|CAH72454.1| 873|Homo sapiens very low density
lipoprotein receptor protein.
Length = 873
Score = 178 bits (434), Expect = 8e-44
Identities = 100/289 (34%), Positives = 159/289 (55%), Gaps = 15/289 (5%)
Query: 13 IAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAID 72
+ + L A+D + W+D + I + ++ G K++ + + P IA+D
Sbjct: 464 LVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDK-VGRHVKMI-DNVYNPAAIAVD 521
Query: 73 WYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKI 132
W +YWTD + I V ++ RK LF S++ +IAV P G ++W+DWGE KI
Sbjct: 522 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKI 581
Query: 133 ERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVK 192
E+AGMNG R+ +V +I WPNGIT+D S +YW+D+KL + +D NG+ R+ V+K
Sbjct: 582 EKAGMNG--FDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLK 639
Query: 193 G--GLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESR 250
L +P ALT D++YW D +N ++Y + G ++ L+ + DI VY E
Sbjct: 640 SLEFLAHPLALTIFEDRVYWIDGENEAVYGAN-KFTGSELATLVNNLNDAQDIIVYHELV 698
Query: 251 QIISAEDYPCKKN--NAGCSHLCLLSPD----PPGYNCACPTGVKLREN 293
Q S +++ C+++ N GC +LCL +P P Y C+CP+G + EN
Sbjct: 699 Q-PSGKNW-CEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEEN 745
Score = 173 bits (420), Expect = 4e-42
Identities = 98/359 (27%), Positives = 176/359 (49%), Gaps = 16/359 (4%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTC--VEPEAFLVYSRKNIIGRLSIKNEYNDA 630
G CS +C N Y C C G ++ C V E L+++ + I ++ + E +
Sbjct: 404 GICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGL--ERKEY 461
Query: 631 VIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVE--KIVEWLGLVEGLAID 688
+ ++ L+ AL ++ KL+W+D K I S++ K+++ + +A+D
Sbjct: 462 IQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVD 521
Query: 689 WSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS-I 747
W + IYWTD ++ I V+ LDG+ R+ + L++P SI +DP G++YWS+ G + I
Sbjct: 522 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKI 581
Query: 748 KRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNI 806
++A M+G + + + + +D + +YW ++ LNG R+ + ++
Sbjct: 582 EKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSL 641
Query: 807 PM---PYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHR-AKSM 862
P AL +F D VYW D + A K GS ++ +L+ D+ +YH +
Sbjct: 642 EFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPS 701
Query: 863 GSNQC--GVDNGGCSHLCLPTP--GDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQ 917
G N C ++NGGC +LCLP P D Y C+CP+ Y + ++ C + +++
Sbjct: 702 GKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSE 760
Score = 169 bits (410), Expect = 7e-41
Identities = 105/365 (28%), Positives = 174/365 (47%), Gaps = 19/365 (5%)
Query: 262 KNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDS 321
+N CS +C+ GY C C G ++ + + L+ R I KI L+
Sbjct: 401 QNPGICSQICINLKG--GYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLER 458
Query: 322 PDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGV--P 379
+ Y ++ L+ T+ +D D + ++WAD K I A +D V V P
Sbjct: 459 KE---YIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNP 515
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDW 439
+IA+D + + IYWTD TI+VA LDG+ K + +++L +P +IA+ +G+++WSDW
Sbjct: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
Query: 440 NEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTER 499
E KIE+A ++G R L++ + WPN I LD + ++LYW D++ H + +++G +R
Sbjct: 576 GE-PAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDR 634
Query: 500 K-ELHSNDII-HIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAF 557
+ L S + + H + + NK TG + +V + + + +
Sbjct: 635 RIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVY 694
Query: 558 -RLGAPLGWNPCADD--NGGCSHLCFNRPD------DYICGCPLGLELTADKKTCVEPEA 608
L P G N C +D NGGC +LC P Y C CP G + + + C
Sbjct: 695 HELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTAT 754
Query: 609 FLVYS 613
+ YS
Sbjct: 755 TVTYS 759
Score = 83.8 bits (198), Expect = 3e-15
Identities = 71/294 (24%), Positives = 129/294 (43%), Gaps = 14/294 (4%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGR--LSI 623
N C +NGGCSH+C + Y C C G EL D+KTC + + I + +++
Sbjct: 358 NECLVNNGGCSHICKDLVIGYECDCAAGFEL-IDRKTCGDIDE---CQNPGICSQICINL 413
Query: 624 KNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVE 683
K Y + + + V G + + + I + + ++VE L
Sbjct: 414 KGGYKCECSRGYQMDLATGVCKAV-GKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTV 472
Query: 684 GLAIDWSGQNIYWTDTTTQRIEVSRLDGS-SRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
L D + Q ++W D + + I + +D R + + P +I +D +YW++
Sbjct: 473 ALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDA 532
Query: 743 GSKSIKRAAMDGSSVS-VFMEQVGRVHALAIDYERRAIYWAAL-DPPVVEFAFLNGTGRQ 800
SK+I A +DG+ +F + ++A+D +YW+ +P +E A +NG R+
Sbjct: 533 ASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRR 592
Query: 801 TL--AD-NIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYIS 851
L AD P L L +YW D + +G +R+ + K L++++
Sbjct: 593 PLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSV-DLNGQDRRIVLKSLEFLA 645
Score = 74.9 bits (176), Expect = 2e-12
Identities = 69/252 (27%), Positives = 108/252 (42%), Gaps = 16/252 (6%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISL 319
C NN GCSH+C GY C C G +L + + D Q + +Q K
Sbjct: 360 CLVNNGGCSHIC--KDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGY 417
Query: 320 DSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGVP 379
Y + DL + + I+ + I K L+ + +V
Sbjct: 418 KCECSRGYQM---DLATGVCKAVGKEPSLIFTN---RRDIRKIGLERKEYIQLVEQLRNT 471
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLD---GSYEKVIIHTELYDPRAIALHLTAGWMFW 436
++ D ++K++W D I A +D G + K+I +Y+P AIA+ ++W
Sbjct: 472 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNPAAIAVDWVYKTIYW 529
Query: 437 SDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGD-ARTHKIEVCNMD 495
+D K I A LDG+ R L + L P SIA+D ++ +YW D KIE M+
Sbjct: 530 TDAASK--TISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMN 587
Query: 496 GTERKELHSNDI 507
G +R+ L + DI
Sbjct: 588 GFDRRPLVTADI 599
Score = 61.7 bits (143), Expect = 2e-08
Identities = 59/256 (23%), Positives = 105/256 (41%), Gaps = 20/256 (7%)
Query: 846 DLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNIT 905
+ D + +L R ++C + G CS +C+ G Y+C C Y+++
Sbjct: 379 ECDCAAGFELIDRKTCGDIDECQ-NPGICSQICINLKGG----YKCECSRGYQMDLATGV 433
Query: 906 CSE--PEEFLLFAQKNAVGRIMVANGECNDAYIPLTG-LKNVRAIEYDPVEKQLYWMDDD 962
C E L+F + + +I + E YI L L+N A++ D ++L+W D
Sbjct: 434 CKAVGKEPSLIFTNRRDIRKIGLERKE----YIQLVEQLRNTVALDADIAAQKLFWADLS 489
Query: 963 SHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNN 1022
+I S + P + +D + +T+YWT A +I+ ++D
Sbjct: 490 QKAI----FSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLD-G 544
Query: 1023 SSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGA-IMRANVDGTGRVELARADN--ATA 1079
+ + D P +A ++ W+D G A I +A ++G R L AD
Sbjct: 545 TKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNG 604
Query: 1080 LALDQSAGTVYWAVSR 1095
+ LD +YW S+
Sbjct: 605 ITLDLIKSRLYWLDSK 620
Score = 55.2 bits (127), Expect = 1e-06
Identities = 54/232 (23%), Positives = 92/232 (39%), Gaps = 20/232 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL--FAQKNAVG 922
N+C V+NGGCSH+C D+ Y C C A + L D TC + +E + +
Sbjct: 358 NECLVNNGGCSHIC----KDLVIGYECDCAAGFEL-IDRKTCGDIDECQNPGICSQICIN 412
Query: 923 RIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXX 982
EC+ Y +A+ +P L + + IR++ +
Sbjct: 413 LKGGYKCECSRGYQMDLATGVCKAVGKEP---SLIF--TNRRDIRKIGLERKEYIQLVEQ 467
Query: 983 XXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFH 1042
L D+ + ++W + +I + SID+ V + + P +A
Sbjct: 468 LRNTVALD------ADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVD 521
Query: 1043 QTKRYLIWNDVGRGAIMRANVDGTGRVELARAD--NATALALDQSAGTVYWA 1092
+ + W D I A +DGT R L +D ++A+D +G VYW+
Sbjct: 522 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWS 573
Score = 53.2 bits (122), Expect = 5e-06
Identities = 32/90 (35%), Positives = 42/90 (46%), Gaps = 29/90 (32%)
Query: 1093 VSRQCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDE 1152
VS +CDG+ DC+ G DE CG ++ C+ D F C
Sbjct: 130 VSWRCDGENDCDSGEDEENCG----NITCSP----------------------DEFTCSS 163
Query: 1153 GLCIAARFVCDGRPQCADGSDE---APAAC 1179
G CI+ FVC+G+ C+DGSDE AP C
Sbjct: 164 GRCISRNFVCNGQDDCSDGSDELDCAPPTC 193
Score = 52.4 bits (120), Expect = 9e-06
Identities = 28/85 (32%), Positives = 37/85 (43%), Gaps = 9/85 (10%)
Query: 1096 QCDGQQ-DCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGL 1154
+C+ Q C +GR C GD C DG+ F C+ G
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESD--------FVCNNGQ 83
Query: 1155 CIAARFVCDGRPQCADGSDEAPAAC 1179
C+ +R+ CDG P C DGSDE+P C
Sbjct: 84 CVPSRWKCDGDPDCEDGSDESPEQC 108
Score = 43.6 bits (98), Expect = 0.004
Identities = 30/99 (30%), Positives = 38/99 (38%), Gaps = 22/99 (22%)
Query: 1097 CDGQQDCEDGRDEAEC-----GA----------------CGGDVRCADGTXXXXXXXXXX 1135
C+GQ DC DG DE +C GA C D C+D +
Sbjct: 173 CNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQ 232
Query: 1136 XXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
+ +C G CI ++ CDG P C DGSDE
Sbjct: 233 PVIHTKCPASE-IQCGSGECIHKKWRCDGDPDCKDGSDE 270
Score = 37.5 bits (83), Expect = 0.29
Identities = 28/99 (28%), Positives = 34/99 (34%), Gaps = 15/99 (15%)
Query: 1096 QCDGQQDCEDGRDEAECGA--CGGD-VRCADGTXXXXXXXXXXXXXXXXXXXX------- 1145
+CDG DC+DG DE C + C D C DG+
Sbjct: 257 RCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVN 316
Query: 1146 -----DAFRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F+C G CI VC+ C D SDE C
Sbjct: 317 QCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKEC 355
Score = 33.1 bits (72), Expect = 6.2
Identities = 12/19 (63%), Positives = 14/19 (73%)
Query: 1094 SRQCDGQQDCEDGRDEAEC 1112
SRQC+G +DC DG DE C
Sbjct: 294 SRQCNGIRDCVDGSDEVNC 312
>AL450467-2|CAH72453.1| 752|Homo sapiens very low density
lipoprotein receptor protein.
Length = 752
Score = 178 bits (434), Expect = 8e-44
Identities = 100/289 (34%), Positives = 159/289 (55%), Gaps = 15/289 (5%)
Query: 13 IAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAID 72
+ + L A+D + W+D + I + ++ G K++ + + P IA+D
Sbjct: 343 LVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDK-VGRHVKMI-DNVYNPAAIAVD 400
Query: 73 WYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKI 132
W +YWTD + I V ++ RK LF S++ +IAV P G ++W+DWGE KI
Sbjct: 401 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKI 460
Query: 133 ERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVK 192
E+AGMNG R+ +V +I WPNGIT+D S +YW+D+KL + +D NG+ R+ V+K
Sbjct: 461 EKAGMNG--FDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLK 518
Query: 193 G--GLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESR 250
L +P ALT D++YW D +N ++Y + G ++ L+ + DI VY E
Sbjct: 519 SLEFLAHPLALTIFEDRVYWIDGENEAVYGAN-KFTGSELATLVNNLNDAQDIIVYHELV 577
Query: 251 QIISAEDYPCKKN--NAGCSHLCLLSPD----PPGYNCACPTGVKLREN 293
Q S +++ C+++ N GC +LCL +P P Y C+CP+G + EN
Sbjct: 578 Q-PSGKNW-CEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEEN 624
Score = 173 bits (420), Expect = 4e-42
Identities = 98/359 (27%), Positives = 176/359 (49%), Gaps = 16/359 (4%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTC--VEPEAFLVYSRKNIIGRLSIKNEYNDA 630
G CS +C N Y C C G ++ C V E L+++ + I ++ + E +
Sbjct: 283 GICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGL--ERKEY 340
Query: 631 VIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVE--KIVEWLGLVEGLAID 688
+ ++ L+ AL ++ KL+W+D K I S++ K+++ + +A+D
Sbjct: 341 IQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVD 400
Query: 689 WSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS-I 747
W + IYWTD ++ I V+ LDG+ R+ + L++P SI +DP G++YWS+ G + I
Sbjct: 401 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKI 460
Query: 748 KRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNI 806
++A M+G + + + + +D + +YW ++ LNG R+ + ++
Sbjct: 461 EKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSL 520
Query: 807 PM---PYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHR-AKSM 862
P AL +F D VYW D + A K GS ++ +L+ D+ +YH +
Sbjct: 521 EFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPS 580
Query: 863 GSNQC--GVDNGGCSHLCLPTP--GDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQ 917
G N C ++NGGC +LCLP P D Y C+CP+ Y + ++ C + +++
Sbjct: 581 GKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSE 639
Score = 169 bits (410), Expect = 7e-41
Identities = 105/365 (28%), Positives = 174/365 (47%), Gaps = 19/365 (5%)
Query: 262 KNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDS 321
+N CS +C+ GY C C G ++ + + L+ R I KI L+
Sbjct: 280 QNPGICSQICINLKG--GYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLER 337
Query: 322 PDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGV--P 379
+ Y ++ L+ T+ +D D + ++WAD K I A +D V V P
Sbjct: 338 KE---YIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNP 394
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDW 439
+IA+D + + IYWTD TI+VA LDG+ K + +++L +P +IA+ +G+++WSDW
Sbjct: 395 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 454
Query: 440 NEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTER 499
E KIE+A ++G R L++ + WPN I LD + ++LYW D++ H + +++G +R
Sbjct: 455 GE-PAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDR 513
Query: 500 K-ELHSNDII-HIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAF 557
+ L S + + H + + NK TG + +V + + + +
Sbjct: 514 RIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVY 573
Query: 558 -RLGAPLGWNPCADD--NGGCSHLCFNRPD------DYICGCPLGLELTADKKTCVEPEA 608
L P G N C +D NGGC +LC P Y C CP G + + + C
Sbjct: 574 HELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTAT 633
Query: 609 FLVYS 613
+ YS
Sbjct: 634 TVTYS 638
Score = 83.8 bits (198), Expect = 3e-15
Identities = 71/294 (24%), Positives = 129/294 (43%), Gaps = 14/294 (4%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGR--LSI 623
N C +NGGCSH+C + Y C C G EL D+KTC + + I + +++
Sbjct: 237 NECLVNNGGCSHICKDLVIGYECDCAAGFEL-IDRKTCGDIDE---CQNPGICSQICINL 292
Query: 624 KNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVE 683
K Y + + + V G + + + I + + ++VE L
Sbjct: 293 KGGYKCECSRGYQMDLATGVCKAV-GKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTV 351
Query: 684 GLAIDWSGQNIYWTDTTTQRIEVSRLDGS-SRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
L D + Q ++W D + + I + +D R + + P +I +D +YW++
Sbjct: 352 ALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDA 411
Query: 743 GSKSIKRAAMDGSSVS-VFMEQVGRVHALAIDYERRAIYWAAL-DPPVVEFAFLNGTGRQ 800
SK+I A +DG+ +F + ++A+D +YW+ +P +E A +NG R+
Sbjct: 412 ASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRR 471
Query: 801 TL--AD-NIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYIS 851
L AD P L L +YW D + +G +R+ + K L++++
Sbjct: 472 PLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSV-DLNGQDRRIVLKSLEFLA 524
Score = 74.9 bits (176), Expect = 2e-12
Identities = 69/252 (27%), Positives = 108/252 (42%), Gaps = 16/252 (6%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISL 319
C NN GCSH+C GY C C G +L + + D Q + +Q K
Sbjct: 239 CLVNNGGCSHIC--KDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGY 296
Query: 320 DSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGVP 379
Y + DL + + I+ + I K L+ + +V
Sbjct: 297 KCECSRGYQM---DLATGVCKAVGKEPSLIFTN---RRDIRKIGLERKEYIQLVEQLRNT 350
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLD---GSYEKVIIHTELYDPRAIALHLTAGWMFW 436
++ D ++K++W D I A +D G + K+I +Y+P AIA+ ++W
Sbjct: 351 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNPAAIAVDWVYKTIYW 408
Query: 437 SDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGD-ARTHKIEVCNMD 495
+D K I A LDG+ R L + L P SIA+D ++ +YW D KIE M+
Sbjct: 409 TDAASK--TISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMN 466
Query: 496 GTERKELHSNDI 507
G +R+ L + DI
Sbjct: 467 GFDRRPLVTADI 478
Score = 61.7 bits (143), Expect = 2e-08
Identities = 59/256 (23%), Positives = 105/256 (41%), Gaps = 20/256 (7%)
Query: 846 DLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNIT 905
+ D + +L R ++C + G CS +C+ G Y+C C Y+++
Sbjct: 258 ECDCAAGFELIDRKTCGDIDECQ-NPGICSQICINLKGG----YKCECSRGYQMDLATGV 312
Query: 906 CSE--PEEFLLFAQKNAVGRIMVANGECNDAYIPLTG-LKNVRAIEYDPVEKQLYWMDDD 962
C E L+F + + +I + E YI L L+N A++ D ++L+W D
Sbjct: 313 CKAVGKEPSLIFTNRRDIRKIGLERKE----YIQLVEQLRNTVALDADIAAQKLFWADLS 368
Query: 963 SHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNN 1022
+I S + P + +D + +T+YWT A +I+ ++D
Sbjct: 369 QKAI----FSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLD-G 423
Query: 1023 SSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGA-IMRANVDGTGRVELARADN--ATA 1079
+ + D P +A ++ W+D G A I +A ++G R L AD
Sbjct: 424 TKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNG 483
Query: 1080 LALDQSAGTVYWAVSR 1095
+ LD +YW S+
Sbjct: 484 ITLDLIKSRLYWLDSK 499
Score = 55.2 bits (127), Expect = 1e-06
Identities = 54/232 (23%), Positives = 92/232 (39%), Gaps = 20/232 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL--FAQKNAVG 922
N+C V+NGGCSH+C D+ Y C C A + L D TC + +E + +
Sbjct: 237 NECLVNNGGCSHIC----KDLVIGYECDCAAGFEL-IDRKTCGDIDECQNPGICSQICIN 291
Query: 923 RIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXX 982
EC+ Y +A+ +P L + + IR++ +
Sbjct: 292 LKGGYKCECSRGYQMDLATGVCKAVGKEP---SLIF--TNRRDIRKIGLERKEYIQLVEQ 346
Query: 983 XXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFH 1042
L D+ + ++W + +I + SID+ V + + P +A
Sbjct: 347 LRNTVALD------ADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVD 400
Query: 1043 QTKRYLIWNDVGRGAIMRANVDGTGRVELARAD--NATALALDQSAGTVYWA 1092
+ + W D I A +DGT R L +D ++A+D +G VYW+
Sbjct: 401 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWS 452
Score = 44.4 bits (100), Expect = 0.002
Identities = 37/131 (28%), Positives = 51/131 (38%), Gaps = 28/131 (21%)
Query: 1065 GTGRVELARADNATALALDQSAGTVYWAVSRQCDGQQDCEDGRDEAEC-----GA----- 1114
GTGR A+ + + + T+ W +CDG +DC DG DE +C GA
Sbjct: 26 GTGRK--AKCEPSQFQCTNGRCITLLW----KCDGDEDCVDGSDELDCAPPTCGAHEFQC 79
Query: 1115 -----------CGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCD 1163
C D C+D + + +C G CI ++ CD
Sbjct: 80 STSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASE-IQCGSGECIHKKWRCD 138
Query: 1164 GRPQCADGSDE 1174
G P C DGSDE
Sbjct: 139 GDPDCKDGSDE 149
Score = 38.7 bits (86), Expect = 0.12
Identities = 17/35 (48%), Positives = 19/35 (54%), Gaps = 3/35 (8%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDE---APAAC 1179
F+C G CI + CDG C DGSDE AP C
Sbjct: 38 FQCTNGRCITLLWKCDGDEDCVDGSDELDCAPPTC 72
Score = 37.5 bits (83), Expect = 0.29
Identities = 28/99 (28%), Positives = 34/99 (34%), Gaps = 15/99 (15%)
Query: 1096 QCDGQQDCEDGRDEAECGA--CGGD-VRCADGTXXXXXXXXXXXXXXXXXXXX------- 1145
+CDG DC+DG DE C + C D C DG+
Sbjct: 136 RCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVN 195
Query: 1146 -----DAFRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F+C G CI VC+ C D SDE C
Sbjct: 196 QCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKEC 234
Score = 37.1 bits (82), Expect = 0.38
Identities = 24/85 (28%), Positives = 32/85 (37%), Gaps = 9/85 (10%)
Query: 1096 QCDGQQ-DCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGL 1154
+C+ Q C +GR C GD C DG+ F+C
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDELDCAPPTCGAHE--------FQCSTSS 83
Query: 1155 CIAARFVCDGRPQCADGSDEAPAAC 1179
CI +VCD C+D SDE+ C
Sbjct: 84 CIPISWVCDDDADCSDQSDESLEQC 108
Score = 33.1 bits (72), Expect = 6.2
Identities = 12/19 (63%), Positives = 14/19 (73%)
Query: 1094 SRQCDGQQDCEDGRDEAEC 1112
SRQC+G +DC DG DE C
Sbjct: 173 SRQCNGIRDCVDGSDEVNC 191
>AL355483-3|CAI22782.1| 700|Homo sapiens low density lipoprotein
receptor-related protein 8, apolipoprotein e receptor
protein.
Length = 700
Score = 178 bits (434), Expect = 8e-44
Identities = 98/277 (35%), Positives = 151/277 (54%), Gaps = 11/277 (3%)
Query: 17 LEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKI-VSEGLVTPTGIAIDWYT 75
L+ A+D N I W D I ++ ++ ++ + E L +P G+A+DW
Sbjct: 320 LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVH 379
Query: 76 DKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERA 135
+YWTD I V ++ R+ LF + RAIAV P G M+W+DWG+ KIE++
Sbjct: 380 KHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKS 439
Query: 136 GMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVKGG- 194
G+NG R+ +V DNI WPNGIT+D + +YWVD+KL + IDF+G RK ++
Sbjct: 440 GLNG--VDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTD 497
Query: 195 -LVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESRQII 253
L +PF + DK++WTD +N +I++ + NG +I L ++ P DI ++ E +Q
Sbjct: 498 FLSHPFGIAVFEDKVFWTDLENEAIFSAN-RLNGLEISILAENLNNPHDIVIFHELKQPR 556
Query: 254 SAEDYPCK-KNNAGCSHLCLLSPD----PPGYNCACP 285
+ + + N GC +LCL +P P Y CACP
Sbjct: 557 APDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACP 593
Score = 165 bits (401), Expect = 8e-40
Identities = 111/365 (30%), Positives = 175/365 (47%), Gaps = 31/365 (8%)
Query: 260 CKKNNAGCSHLCLLSPDPPGY-NCACPTGVK---LRENSSTTCYDSPQMLLVVAQRSTIS 315
CK +A CS +C+ + GY C C G + L +N SP L+ R +
Sbjct: 251 CKDPDA-CSQICV---NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPS--LIFTNRHEVR 304
Query: 316 KISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGS----DQSV 371
+I L +++ +P+ LK + +D + T IYW D + I A +D + +Q V
Sbjct: 305 RIDLVKRNYSRL-IPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEV 361
Query: 372 VVRSS-GVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLT 430
++ P+ +A+D + + IYWTD TI+VA +DG + + L +PRAIA+
Sbjct: 362 LIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPL 421
Query: 431 AGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIE 490
G+M+WSDW + + KIE++ L+G R L+S+ + WPN I LD ++ +LYW D++ H++
Sbjct: 422 RGFMYWSDWGD-QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS 480
Query: 491 VCNMDGTERKEL-HSNDII-HIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQM 548
+ G RK L S D + H FG ++ + N+ GL+ + E +
Sbjct: 481 SIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL 540
Query: 549 ANMMGVKAF-RLGAPLGWNPC---ADDNGGCSHLCFNRPD------DYICGCPLGLELTA 598
N + F L P + C NGGC +LC P Y C CP + L
Sbjct: 541 NNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGP 600
Query: 599 DKKTC 603
D K C
Sbjct: 601 DMKRC 605
Score = 163 bits (397), Expect = 3e-39
Identities = 100/355 (28%), Positives = 175/355 (49%), Gaps = 21/355 (5%)
Query: 571 DNGGCSHLCFNRPDDYICGCPLGLE---LTADKKTCVEPEAFLVYSRKNIIGRLSIKNEY 627
D CS +C N + C C G E LT + K L+++ ++ + R+ +
Sbjct: 253 DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRN 312
Query: 628 NDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEK-----IVEWLGLV 682
+IP+ LK V AL + V+ +++YW D + I ++ ++ K I E L
Sbjct: 313 YSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSP 370
Query: 683 EGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
EGLA+DW ++IYWTD+ + I V+ +DG RR + + L +P++I +DP +G+MYWS+
Sbjct: 371 EGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW 430
Query: 743 GSKS-IKRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQ 800
G ++ I+++ ++G ++ + + + + +D + +YW + +G R+
Sbjct: 431 GDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRK 490
Query: 801 TL---ADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYH 857
TL D + P+ +A+F D V+W D I A + +G + ++L+ D+ ++H
Sbjct: 491 TLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFH 550
Query: 858 RAKS-MGSNQCGVD---NGGCSHLCLPTP--GDVRTDYRCACPAHYRLNKDNITC 906
K + C + NGGC +LCLP P Y CACP L D C
Sbjct: 551 ELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 605
Score = 108 bits (260), Expect = 1e-22
Identities = 79/301 (26%), Positives = 141/301 (46%), Gaps = 12/301 (3%)
Query: 560 GAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIG 619
G G N C +NGGCSH+C + + C CP G +L D+KTC + + + I
Sbjct: 203 GCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGDIDECKDPDACSQI- 260
Query: 620 RLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWL 679
++ K + P ++ ++ +G + + R + +++ L
Sbjct: 261 CVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPML 320
Query: 680 GLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSS----RRAIIWQGLKKPKSIVLDPKKG 735
V L ++ + IYW D + ++I + +D +S + +I + L P+ + +D
Sbjct: 321 KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHK 380
Query: 736 YMYWSELGSKSIKRAAMDGS-SVSVFMEQVGRVHALAIDYERRAIYWAAL-DPPVVEFAF 793
++YW++ G+K+I A +DG ++F + A+A+D R +YW+ D +E +
Sbjct: 381 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSG 440
Query: 794 LNGTGRQTL-ADNIPMP--YALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYI 850
LNG RQTL +DNI P L L + +YW D Q+ G NRK++ D++
Sbjct: 441 LNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSI-DFSGGNRKTLISSTDFL 499
Query: 851 S 851
S
Sbjct: 500 S 500
Score = 73.3 bits (172), Expect = 5e-12
Identities = 62/253 (24%), Positives = 109/253 (43%), Gaps = 14/253 (5%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISL 319
C NN GCSH+C + G+ C CP G +L + + D + +Q K
Sbjct: 211 CLHNNGGCSHIC--TDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 268
Query: 320 DSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGVP 379
+ Y + L L + I+ + I + + S ++++
Sbjct: 269 KCECYPGYEMDL--LTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVAL 326
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLDGS----YEKVIIHTELYDPRAIALHLTAGWMF 435
D ++ + +IYW D I A +D + ++V+I +L+ P +A+ ++
Sbjct: 327 D---VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 383
Query: 436 WSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGD-ARTHKIEVCNM 494
W+D K I A +DG R L S L+ P +IA+D + +YW D KIE +
Sbjct: 384 WTDSGNK--TISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGL 441
Query: 495 DGTERKELHSNDI 507
+G +R+ L S++I
Sbjct: 442 NGVDRQTLVSDNI 454
Score = 57.2 bits (132), Expect = 3e-07
Identities = 60/240 (25%), Positives = 92/240 (38%), Gaps = 28/240 (11%)
Query: 863 GSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVG 922
G N+C +NGGCSH+C D++ + C CPA ++L D TC + +E +A
Sbjct: 207 GLNECLHNNGGCSHICT----DLKIGFECTCPAGFQL-LDQKTCGDIDE---CKDPDACS 258
Query: 923 RIMV-----ANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXX 977
+I V EC Y KN +A K + + H +RR+ +
Sbjct: 259 QICVNYKGYFKCECYPGYEMDLLTKNCKA----AAGKSPSLIFTNRHEVRRIDLVKRNYS 314
Query: 978 XXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNS---STGVIVRGDRM 1034
L ++V +YW I + +D S V++
Sbjct: 315 RLIPMLKNVVALD------VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH 368
Query: 1035 LPRHLAFHQTKRYLIWNDVGRGAIMRANVDGTGRVEL--ARADNATALALDQSAGTVYWA 1092
P LA +++ W D G I A VDG R L A+A+D G +YW+
Sbjct: 369 SPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWS 428
Score = 56.0 bits (129), Expect = 8e-07
Identities = 54/235 (22%), Positives = 101/235 (42%), Gaps = 21/235 (8%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYR---LNKDNITCSEPEEFLLFAQKNAVGRIMV 926
D CS +C+ G ++C C Y L K+ + L+F ++ V RI +
Sbjct: 253 DPDACSQICVNYKGY----FKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDL 308
Query: 927 ANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXX--XXXXXX 984
+ IP+ LKNV A++ + ++YW D S R++ +Y
Sbjct: 309 VKRNYS-RLIPM--LKNVVALDVEVATNRIYWCD---LSYRKIYSAYMDKASDPKEQEVL 362
Query: 985 XXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQT 1044
L P + +D + + +YWT + +I+ ++D + R + PR +A
Sbjct: 363 IDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSR-NLSEPRAIAVDPL 421
Query: 1045 KRYLIWNDVG-RGAIMRANVDGTGRVELARADN---ATALALDQSAGTVYWAVSR 1095
+ ++ W+D G + I ++ ++G R L +DN + LD + +YW S+
Sbjct: 422 RGFMYWSDWGDQAKIEKSGLNGVDRQTLV-SDNIEWPNGITLDLLSQRLYWVDSK 475
Score = 47.2 bits (107), Expect = 4e-04
Identities = 18/32 (56%), Positives = 21/32 (65%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F CD G CI R+ CDG +C DGSDE+ A C
Sbjct: 91 FTCDNGHCIHERWKCDGEEECPDGSDESEATC 122
Score = 43.2 bits (97), Expect = 0.006
Identities = 28/82 (34%), Positives = 35/82 (42%), Gaps = 24/82 (29%)
Query: 1094 SRQCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEG 1153
S +CDG++DCE G DEA C G R D F+C +G
Sbjct: 145 SWRCDGEKDCEGGADEAGCATSLGTCR------------------------GDEFQCGDG 180
Query: 1154 LCIAARFVCDGRPQCADGSDEA 1175
C+ A C+ C DGSDEA
Sbjct: 181 TCVLAIKHCNQEQDCPDGSDEA 202
>AK092381-1|BAC03874.1| 752|Homo sapiens protein ( Homo sapiens
cDNA FLJ35062 fis, clone OCBBF2019195, highly similar to
VERY LOW-DENSITY LIPOPROTEIN RECEPTOR PRECURSOR. ).
Length = 752
Score = 178 bits (434), Expect = 8e-44
Identities = 100/289 (34%), Positives = 159/289 (55%), Gaps = 15/289 (5%)
Query: 13 IAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAID 72
+ + L A+D + W+D + I + ++ G K++ + + P IA+D
Sbjct: 343 LVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDK-VGRHVKMI-DNVYNPAAIAVD 400
Query: 73 WYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKI 132
W +YWTD + I V ++ RK LF S++ +IAV P G ++W+DWGE KI
Sbjct: 401 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKI 460
Query: 133 ERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVK 192
E+AGMNG R+ +V +I WPNGIT+D S +YW+D+KL + +D NG+ R+ V+K
Sbjct: 461 EKAGMNG--FDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLK 518
Query: 193 G--GLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESR 250
L +P ALT D++YW D +N ++Y + G ++ L+ + DI VY E
Sbjct: 519 SLEFLAHPLALTIFEDRVYWIDGENEAVYGAN-KFTGSELATLVNNLNDAQDIIVYHELV 577
Query: 251 QIISAEDYPCKKN--NAGCSHLCLLSPD----PPGYNCACPTGVKLREN 293
Q S +++ C+++ N GC +LCL +P P Y C+CP+G + EN
Sbjct: 578 Q-PSGKNW-CEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEEN 624
Score = 173 bits (420), Expect = 4e-42
Identities = 98/359 (27%), Positives = 176/359 (49%), Gaps = 16/359 (4%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTC--VEPEAFLVYSRKNIIGRLSIKNEYNDA 630
G CS +C N Y C C G ++ C V E L+++ + I ++ + E +
Sbjct: 283 GICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGL--ERKEY 340
Query: 631 VIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVE--KIVEWLGLVEGLAID 688
+ ++ L+ AL ++ KL+W+D K I S++ K+++ + +A+D
Sbjct: 341 IQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVD 400
Query: 689 WSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS-I 747
W + IYWTD ++ I V+ LDG+ R+ + L++P SI +DP G++YWS+ G + I
Sbjct: 401 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKI 460
Query: 748 KRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNI 806
++A M+G + + + + +D + +YW ++ LNG R+ + ++
Sbjct: 461 EKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSL 520
Query: 807 PM---PYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHR-AKSM 862
P AL +F D VYW D + A K GS ++ +L+ D+ +YH +
Sbjct: 521 EFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPS 580
Query: 863 GSNQC--GVDNGGCSHLCLPTP--GDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQ 917
G N C ++NGGC +LCLP P D Y C+CP+ Y + ++ C + +++
Sbjct: 581 GKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSE 639
Score = 169 bits (410), Expect = 7e-41
Identities = 105/365 (28%), Positives = 174/365 (47%), Gaps = 19/365 (5%)
Query: 262 KNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDS 321
+N CS +C+ GY C C G ++ + + L+ R I KI L+
Sbjct: 280 QNPGICSQICINLKG--GYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLER 337
Query: 322 PDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGV--P 379
+ Y ++ L+ T+ +D D + ++WAD K I A +D V V P
Sbjct: 338 KE---YIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNP 394
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDW 439
+IA+D + + IYWTD TI+VA LDG+ K + +++L +P +IA+ +G+++WSDW
Sbjct: 395 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 454
Query: 440 NEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTER 499
E KIE+A ++G R L++ + WPN I LD + ++LYW D++ H + +++G +R
Sbjct: 455 GE-PAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDR 513
Query: 500 K-ELHSNDII-HIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAF 557
+ L S + + H + + NK TG + +V + + + +
Sbjct: 514 RIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVY 573
Query: 558 -RLGAPLGWNPCADD--NGGCSHLCFNRPD------DYICGCPLGLELTADKKTCVEPEA 608
L P G N C +D NGGC +LC P Y C CP G + + + C
Sbjct: 574 HELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTAT 633
Query: 609 FLVYS 613
+ YS
Sbjct: 634 TVTYS 638
Score = 83.8 bits (198), Expect = 3e-15
Identities = 71/294 (24%), Positives = 129/294 (43%), Gaps = 14/294 (4%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGR--LSI 623
N C +NGGCSH+C + Y C C G EL D+KTC + + I + +++
Sbjct: 237 NECLVNNGGCSHICKDLVIGYECDCAAGFEL-IDRKTCGDIDE---CQNPGICSQICINL 292
Query: 624 KNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVE 683
K Y + + + V G + + + I + + ++VE L
Sbjct: 293 KGGYKCECSRGYQMDLATGVCKAV-GKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTV 351
Query: 684 GLAIDWSGQNIYWTDTTTQRIEVSRLDGS-SRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
L D + Q ++W D + + I + +D R + + P +I +D +YW++
Sbjct: 352 ALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDA 411
Query: 743 GSKSIKRAAMDGSSVS-VFMEQVGRVHALAIDYERRAIYWAAL-DPPVVEFAFLNGTGRQ 800
SK+I A +DG+ +F + ++A+D +YW+ +P +E A +NG R+
Sbjct: 412 ASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRR 471
Query: 801 TL--AD-NIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYIS 851
L AD P L L +YW D + +G +R+ + K L++++
Sbjct: 472 PLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSV-DLNGQDRRIVLKSLEFLA 524
Score = 74.9 bits (176), Expect = 2e-12
Identities = 69/252 (27%), Positives = 108/252 (42%), Gaps = 16/252 (6%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISL 319
C NN GCSH+C GY C C G +L + + D Q + +Q K
Sbjct: 239 CLVNNGGCSHIC--KDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGY 296
Query: 320 DSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGVP 379
Y + DL + + I+ + I K L+ + +V
Sbjct: 297 KCECSRGYQM---DLATGVCKAVGKEPSLIFTN---RRDIRKIGLERKEYIQLVEQLRNT 350
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLD---GSYEKVIIHTELYDPRAIALHLTAGWMFW 436
++ D ++K++W D I A +D G + K+I +Y+P AIA+ ++W
Sbjct: 351 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNPAAIAVDWVYKTIYW 408
Query: 437 SDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGD-ARTHKIEVCNMD 495
+D K I A LDG+ R L + L P SIA+D ++ +YW D KIE M+
Sbjct: 409 TDAASK--TISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMN 466
Query: 496 GTERKELHSNDI 507
G +R+ L + DI
Sbjct: 467 GFDRRPLVTADI 478
Score = 61.7 bits (143), Expect = 2e-08
Identities = 59/256 (23%), Positives = 105/256 (41%), Gaps = 20/256 (7%)
Query: 846 DLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNIT 905
+ D + +L R ++C + G CS +C+ G Y+C C Y+++
Sbjct: 258 ECDCAAGFELIDRKTCGDIDECQ-NPGICSQICINLKGG----YKCECSRGYQMDLATGV 312
Query: 906 CSE--PEEFLLFAQKNAVGRIMVANGECNDAYIPLTG-LKNVRAIEYDPVEKQLYWMDDD 962
C E L+F + + +I + E YI L L+N A++ D ++L+W D
Sbjct: 313 CKAVGKEPSLIFTNRRDIRKIGLERKE----YIQLVEQLRNTVALDADIAAQKLFWADLS 368
Query: 963 SHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNN 1022
+I S + P + +D + +T+YWT A +I+ ++D
Sbjct: 369 QKAI----FSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLD-G 423
Query: 1023 SSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGA-IMRANVDGTGRVELARADN--ATA 1079
+ + D P +A ++ W+D G A I +A ++G R L AD
Sbjct: 424 TKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNG 483
Query: 1080 LALDQSAGTVYWAVSR 1095
+ LD +YW S+
Sbjct: 484 ITLDLIKSRLYWLDSK 499
Score = 55.2 bits (127), Expect = 1e-06
Identities = 54/232 (23%), Positives = 92/232 (39%), Gaps = 20/232 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL--FAQKNAVG 922
N+C V+NGGCSH+C D+ Y C C A + L D TC + +E + +
Sbjct: 237 NECLVNNGGCSHIC----KDLVIGYECDCAAGFEL-IDRKTCGDIDECQNPGICSQICIN 291
Query: 923 RIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXX 982
EC+ Y +A+ +P L + + IR++ +
Sbjct: 292 LKGGYKCECSRGYQMDLATGVCKAVGKEP---SLIF--TNRRDIRKIGLERKEYIQLVEQ 346
Query: 983 XXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFH 1042
L D+ + ++W + +I + SID+ V + + P +A
Sbjct: 347 LRNTVALD------ADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVD 400
Query: 1043 QTKRYLIWNDVGRGAIMRANVDGTGRVELARAD--NATALALDQSAGTVYWA 1092
+ + W D I A +DGT R L +D ++A+D +G VYW+
Sbjct: 401 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWS 452
Score = 44.4 bits (100), Expect = 0.002
Identities = 37/131 (28%), Positives = 51/131 (38%), Gaps = 28/131 (21%)
Query: 1065 GTGRVELARADNATALALDQSAGTVYWAVSRQCDGQQDCEDGRDEAEC-----GA----- 1114
GTGR A+ + + + T+ W +CDG +DC DG DE +C GA
Sbjct: 26 GTGRK--AKCEPSQFQCTNGRCITLLW----KCDGDEDCVDGSDELDCAPPTCGAHEFQC 79
Query: 1115 -----------CGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCD 1163
C D C+D + + +C G CI ++ CD
Sbjct: 80 STSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASE-IQCGSGECIHKKWRCD 138
Query: 1164 GRPQCADGSDE 1174
G P C DGSDE
Sbjct: 139 GDPDCKDGSDE 149
Score = 38.7 bits (86), Expect = 0.12
Identities = 17/35 (48%), Positives = 19/35 (54%), Gaps = 3/35 (8%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDE---APAAC 1179
F+C G CI + CDG C DGSDE AP C
Sbjct: 38 FQCTNGRCITLLWKCDGDEDCVDGSDELDCAPPTC 72
Score = 37.5 bits (83), Expect = 0.29
Identities = 28/99 (28%), Positives = 34/99 (34%), Gaps = 15/99 (15%)
Query: 1096 QCDGQQDCEDGRDEAECGA--CGGD-VRCADGTXXXXXXXXXXXXXXXXXXXX------- 1145
+CDG DC+DG DE C + C D C DG+
Sbjct: 136 RCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVN 195
Query: 1146 -----DAFRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F+C G CI VC+ C D SDE C
Sbjct: 196 QCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKEC 234
Score = 37.1 bits (82), Expect = 0.38
Identities = 24/85 (28%), Positives = 32/85 (37%), Gaps = 9/85 (10%)
Query: 1096 QCDGQQ-DCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGL 1154
+C+ Q C +GR C GD C DG+ F+C
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDELDCAPPTCGAHE--------FQCSTSS 83
Query: 1155 CIAARFVCDGRPQCADGSDEAPAAC 1179
CI +VCD C+D SDE+ C
Sbjct: 84 CIPISWVCDDDADCSDQSDESLEQC 108
Score = 33.1 bits (72), Expect = 6.2
Identities = 12/19 (63%), Positives = 14/19 (73%)
Query: 1094 SRQCDGQQDCEDGRDEAEC 1112
SRQC+G +DC DG DE C
Sbjct: 173 SRQCNGIRDCVDGSDEVNC 191
>S73145-1|AAB30825.1| 268|Homo sapiens calcium sensor protein
protein.
Length = 268
Score = 177 bits (430), Expect = 3e-43
Identities = 92/237 (38%), Positives = 139/237 (58%), Gaps = 11/237 (4%)
Query: 63 LVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMF 122
++ P GIA+DW +YW+D + +IEV + +YRK L +++D AIAV P+ GLMF
Sbjct: 3 VMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMF 62
Query: 123 WTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDY-NNSLIYWVDAKLQFVDVID 181
WTDWG+ PKIE A MNG+ R ++V +++ WP G+++DY NN IYW D K ++ I
Sbjct: 63 WTDWGKEPKIESAWMNGE--DRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIK 120
Query: 182 FNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPA 241
++G R RV+ + P++L D+LYW + ++ + G K K L+ +P
Sbjct: 121 YDGTDR-RVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLV-VNPWLT 178
Query: 242 DIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTC 298
++++ + R S + CK+ CSHLCLL P GY+CACP G E S+T C
Sbjct: 179 QVRIFHQLRYNKSVPNL-CKQI---CSHLCLLRPG--GYSCACPQGSSFIEGSTTEC 229
Score = 134 bits (323), Expect = 2e-30
Identities = 72/217 (33%), Positives = 120/217 (55%), Gaps = 12/217 (5%)
Query: 683 EGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
+G+A+DW G++IYW+D +RIEV++LDG R+ +I L +P +I ++PK G M+W++
Sbjct: 7 DGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDW 66
Query: 743 GSK-SIKRAAMDGSSVSVFM-EQVGRVHALAIDY-ERRAIYWAALDPPVVEFAFLNGTGR 799
G + I+ A M+G ++ + E +G L+IDY IYW+ V+E +GT R
Sbjct: 67 GKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDR 126
Query: 800 QTLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHRA 859
+ +A PY+L +F D +YW G++ + K ++ +++ ++++H+
Sbjct: 127 RVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFHQL 186
Query: 860 KSMGS--NQCGVDNGGCSHLCLPTPGDVRTDYRCACP 894
+ S N C CSHLCL PG Y CACP
Sbjct: 187 RYNKSVPNLC---KQICSHLCLLRPG----GYSCACP 216
Score = 131 bits (316), Expect = 2e-29
Identities = 75/218 (34%), Positives = 114/218 (52%), Gaps = 8/218 (3%)
Query: 379 PDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSD 438
PD IA+D + R IYW+D I VA+LDG Y K +I T+L P AIA++ G MFW+D
Sbjct: 6 PDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTD 65
Query: 439 WNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNN-KLYWGDARTHKIEVCNMDGT 497
W K+PKIE A ++G R +L+ E L WP +++D +NN ++YW D + IE DGT
Sbjct: 66 WG-KEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGT 124
Query: 498 ERKELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAF 557
+R+ + + + ++ + +K + + NK ++ + + V+ F
Sbjct: 125 DRRVI-AKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIF 183
Query: 558 RLGAPLGWNPCADD--NGGCSHLCFNRPDDYICGCPLG 593
L +N + CSHLC RP Y C CP G
Sbjct: 184 H---QLRYNKSVPNLCKQICSHLCLLRPGGYSCACPQG 218
Score = 62.9 bits (146), Expect = 7e-09
Identities = 43/157 (27%), Positives = 80/157 (50%), Gaps = 8/157 (5%)
Query: 348 YIYWADGLAKTISKARLDGSDQSVVVRSS-GVPDSIAIDPLSRKIYWTDPVMD-TINVAR 405
+IYW+D K I A+LDG + ++ + P +IA++P ++WTD + I A
Sbjct: 17 HIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAW 76
Query: 406 LDGSYEKVIIHTELYDPRAIAL-HLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKL 464
++G +++ +L P +++ +L ++WSD+ K+ IE DG+ R ++ E +
Sbjct: 77 MNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDF--KEDVIETIKYDGTDRRVIAKEAM 134
Query: 465 TWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKE 501
N +LD ++LYW ++ N G +KE
Sbjct: 135 ---NPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKE 168
Score = 54.8 bits (126), Expect = 2e-06
Identities = 43/152 (28%), Positives = 77/152 (50%), Gaps = 14/152 (9%)
Query: 724 KPKSIVLDPKKGYMYWSELGSKSIKRAAMDGSSVS-VFMEQVGRVHALAIDYERRAIYWA 782
+P I +D ++YWS++ +K I+ A +DG + + + A+A++ + ++W
Sbjct: 5 QPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWT 64
Query: 783 AL-DPPVVEFAFLNGTGRQTLA-DNIPMPYALA---LFNDSVYWGDWNTGQIQQARKTDG 837
P +E A++NG R L +++ P L+ L ND +YW D+ I+ K DG
Sbjct: 65 DWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETI-KYDG 123
Query: 838 SNRKSIRKD------LDYISDLKLYHRAKSMG 863
++R+ I K+ LD D +LY +K G
Sbjct: 124 TDRRVIAKEAMNPYSLDIFED-QLYWISKEKG 154
Score = 52.0 bits (119), Expect = 1e-05
Identities = 34/127 (26%), Positives = 67/127 (52%), Gaps = 8/127 (6%)
Query: 333 DLKRTLTVDFDPKTEYIYWAD-GLAKTISKARLDGSDQSVVV-RSSGVPDSIAIDPLSR- 389
DL + + +PK ++W D G I A ++G D++++V G P ++ID L+
Sbjct: 45 DLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNND 104
Query: 390 KIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERA 449
+IYW+D D I + DG+ ++ +I E +P +L + ++W +++K ++ +
Sbjct: 105 RIYWSDFKEDVIETIKYDGT-DRRVIAKEAMNP--YSLDIFEDQLYWI--SKEKGEVWKQ 159
Query: 450 NLDGSGR 456
N G G+
Sbjct: 160 NKFGQGK 166
Score = 42.3 bits (95), Expect = 0.010
Identities = 40/153 (26%), Positives = 75/153 (49%), Gaps = 13/153 (8%)
Query: 20 GTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAIDWYTDKLY 79
G AVD+ R I WSD K + I+ + Y K+ ++S L P IA++ ++
Sbjct: 8 GIAVDWVGRH--IYWSDVKNKRIEVAKLDGRY--RKW-LISTDLDQPAAIAVNPKLGLMF 62
Query: 80 WTD-GETNKIEVISIVQKYRKVLFWSEVDLARAIAV-VPEDGLMFWTDWGEIPKIERAGM 137
WTD G+ KIE + + R +L + ++ +++ + ++W+D+ E IE
Sbjct: 63 WTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKE-DVIETIKY 121
Query: 138 NGDPATRKVIVRDNIFWPNGITVDYNNSLIYWV 170
+G R+VI ++ + N ++D +YW+
Sbjct: 122 DG--TDRRVIAKEAM---NPYSLDIFEDQLYWI 149
Score = 41.9 bits (94), Expect = 0.013
Identities = 27/92 (29%), Positives = 51/92 (55%), Gaps = 7/92 (7%)
Query: 13 IAKDLEQGTAVDFHYRKNLICWSD--QKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIA 70
I+ DL+Q A+ + + L+ W+D ++P++ E ++ +V E L PTG++
Sbjct: 42 ISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGE----DRNILVFEDLGWPTGLS 97
Query: 71 IDWY-TDKLYWTDGETNKIEVISIVQKYRKVL 101
ID+ D++YW+D + + IE I R+V+
Sbjct: 98 IDYLNNDRIYWSDFKEDVIETIKYDGTDRRVI 129
>L20470-1|AAA53684.1| 873|Homo sapiens very low density lipoprotein
receptor protein.
Length = 873
Score = 176 bits (429), Expect = 3e-43
Identities = 100/289 (34%), Positives = 158/289 (54%), Gaps = 15/289 (5%)
Query: 13 IAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAID 72
+ + L A+D + W+D + I + ++ G K++ + + P IA+D
Sbjct: 464 LVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDK-VGRHVKMI-DNVYNPAAIAVD 521
Query: 73 WYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKI 132
W +YWTD + I V ++ RK LF S++ +IAV P G ++W+DWGE KI
Sbjct: 522 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKI 581
Query: 133 ERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVK 192
E+AGMNG R+ +V +I WPNGIT+D S +YW+D+KL + +D NG+ R+ V+K
Sbjct: 582 EKAGMNG--FDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLK 639
Query: 193 G--GLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESR 250
L +P ALT D++YW D +N ++Y + G + L+ + DI VY E
Sbjct: 640 SLEFLAHPLALTIFEDRVYWIDGENEAVYGAN-KFTGSEHATLVNNLNDAQDIIVYHELV 698
Query: 251 QIISAEDYPCKKN--NAGCSHLCLLSPD----PPGYNCACPTGVKLREN 293
Q S +++ C+++ N GC +LCL +P P Y C+CP+G + EN
Sbjct: 699 Q-PSGKNW-CEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEEN 745
Score = 171 bits (416), Expect = 1e-41
Identities = 97/359 (27%), Positives = 175/359 (48%), Gaps = 16/359 (4%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTC--VEPEAFLVYSRKNIIGRLSIKNEYNDA 630
G CS +C N Y C C ++ C V E L+++ + I ++ + E +
Sbjct: 404 GICSQICINLKGGYKCECSRAYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGL--ERKEY 461
Query: 631 VIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVE--KIVEWLGLVEGLAID 688
+ ++ L+ AL ++ KL+W+D K I S++ K+++ + +A+D
Sbjct: 462 IQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVD 521
Query: 689 WSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS-I 747
W + IYWTD ++ I V+ LDG+ R+ + L++P SI +DP G++YWS+ G + I
Sbjct: 522 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKI 581
Query: 748 KRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNI 806
++A M+G + + + + +D + +YW ++ LNG R+ + ++
Sbjct: 582 EKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSL 641
Query: 807 PM---PYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHR-AKSM 862
P AL +F D VYW D + A K GS ++ +L+ D+ +YH +
Sbjct: 642 EFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSEHATLVNNLNDAQDIIVYHELVQPS 701
Query: 863 GSNQC--GVDNGGCSHLCLPTP--GDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQ 917
G N C ++NGGC +LCLP P D Y C+CP+ Y + ++ C + +++
Sbjct: 702 GKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSE 760
Score = 167 bits (406), Expect = 2e-40
Identities = 104/365 (28%), Positives = 173/365 (47%), Gaps = 19/365 (5%)
Query: 262 KNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDS 321
+N CS +C+ GY C C ++ + + L+ R I KI L+
Sbjct: 401 QNPGICSQICINLKG--GYKCECSRAYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLER 458
Query: 322 PDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGV--P 379
+ Y ++ L+ T+ +D D + ++WAD K I A +D V V P
Sbjct: 459 KE---YIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNP 515
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDW 439
+IA+D + + IYWTD TI+VA LDG+ K + +++L +P +IA+ +G+++WSDW
Sbjct: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
Query: 440 NEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTER 499
E KIE+A ++G R L++ + WPN I LD + ++LYW D++ H + +++G +R
Sbjct: 576 GE-PAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDR 634
Query: 500 K-ELHSNDII-HIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAF 557
+ L S + + H + + NK TG + +V + + + +
Sbjct: 635 RIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSEHATLVNNLNDAQDIIVY 694
Query: 558 -RLGAPLGWNPCADD--NGGCSHLCFNRPD------DYICGCPLGLELTADKKTCVEPEA 608
L P G N C +D NGGC +LC P Y C CP G + + + C
Sbjct: 695 HELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTAT 754
Query: 609 FLVYS 613
+ YS
Sbjct: 755 TVTYS 759
Score = 85.0 bits (201), Expect = 1e-15
Identities = 71/294 (24%), Positives = 129/294 (43%), Gaps = 14/294 (4%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGR--LSI 623
N C +NGGCSH+C + Y C C G EL D+KTC + + I + +++
Sbjct: 358 NECLVNNGGCSHICKDLVIGYECDCAAGFEL-IDRKTCGDIDE---CQNPGICSQICINL 413
Query: 624 KNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVE 683
K Y + + + V G + + + I + + ++VE L
Sbjct: 414 KGGYKCECSRAYQMDLATGVCKAV-GKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTV 472
Query: 684 GLAIDWSGQNIYWTDTTTQRIEVSRLDGS-SRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
L D + Q ++W D + + I + +D R + + P +I +D +YW++
Sbjct: 473 ALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDA 532
Query: 743 GSKSIKRAAMDGSSVS-VFMEQVGRVHALAIDYERRAIYWAAL-DPPVVEFAFLNGTGRQ 800
SK+I A +DG+ +F + ++A+D +YW+ +P +E A +NG R+
Sbjct: 533 ASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRR 592
Query: 801 TL--AD-NIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYIS 851
L AD P L L +YW D + +G +R+ + K L++++
Sbjct: 593 PLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSV-DLNGQDRRIVLKSLEFLA 645
Score = 75.4 bits (177), Expect = 1e-12
Identities = 69/252 (27%), Positives = 108/252 (42%), Gaps = 16/252 (6%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISL 319
C NN GCSH+C GY C C G +L + + D Q + +Q K
Sbjct: 360 CLVNNGGCSHIC--KDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGY 417
Query: 320 DSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGVP 379
Y + DL + + I+ + I K L+ + +V
Sbjct: 418 KCECSRAYQM---DLATGVCKAVGKEPSLIFTN---RRDIRKIGLERKEYIQLVEQLRNT 471
Query: 380 DSIAIDPLSRKIYWTDPVMDTINVARLD---GSYEKVIIHTELYDPRAIALHLTAGWMFW 436
++ D ++K++W D I A +D G + K+I +Y+P AIA+ ++W
Sbjct: 472 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNPAAIAVDWVYKTIYW 529
Query: 437 SDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGD-ARTHKIEVCNMD 495
+D K I A LDG+ R L + L P SIA+D ++ +YW D KIE M+
Sbjct: 530 TDAASK--TISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMN 587
Query: 496 GTERKELHSNDI 507
G +R+ L + DI
Sbjct: 588 GFDRRPLVTADI 599
Score = 61.7 bits (143), Expect = 2e-08
Identities = 59/256 (23%), Positives = 105/256 (41%), Gaps = 20/256 (7%)
Query: 846 DLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNIT 905
+ D + +L R ++C + G CS +C+ G Y+C C Y+++
Sbjct: 379 ECDCAAGFELIDRKTCGDIDECQ-NPGICSQICINLKGG----YKCECSRAYQMDLATGV 433
Query: 906 CSE--PEEFLLFAQKNAVGRIMVANGECNDAYIPLTG-LKNVRAIEYDPVEKQLYWMDDD 962
C E L+F + + +I + E YI L L+N A++ D ++L+W D
Sbjct: 434 CKAVGKEPSLIFTNRRDIRKIGLERKE----YIQLVEQLRNTVALDADIAAQKLFWADLS 489
Query: 963 SHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNN 1022
+I S + P + +D + +T+YWT A +I+ ++D
Sbjct: 490 QKAI----FSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLD-G 544
Query: 1023 SSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGA-IMRANVDGTGRVELARADN--ATA 1079
+ + D P +A ++ W+D G A I +A ++G R L AD
Sbjct: 545 TKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNG 604
Query: 1080 LALDQSAGTVYWAVSR 1095
+ LD +YW S+
Sbjct: 605 ITLDLIKSRLYWLDSK 620
Score = 56.8 bits (131), Expect = 4e-07
Identities = 55/232 (23%), Positives = 93/232 (40%), Gaps = 20/232 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL--FAQKNAVG 922
N+C V+NGGCSH+C D+ Y C C A + L D TC + +E + +
Sbjct: 358 NECLVNNGGCSHIC----KDLVIGYECDCAAGFEL-IDRKTCGDIDECQNPGICSQICIN 412
Query: 923 RIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXX 982
EC+ AY +A+ +P L + + IR++ +
Sbjct: 413 LKGGYKCECSRAYQMDLATGVCKAVGKEP---SLIF--TNRRDIRKIGLERKEYIQLVEQ 467
Query: 983 XXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFH 1042
L D+ + ++W + +I + SID+ V + + P +A
Sbjct: 468 LRNTVALD------ADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVD 521
Query: 1043 QTKRYLIWNDVGRGAIMRANVDGTGRVELARAD--NATALALDQSAGTVYWA 1092
+ + W D I A +DGT R L +D ++A+D +G VYW+
Sbjct: 522 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWS 573
Score = 53.2 bits (122), Expect = 5e-06
Identities = 32/90 (35%), Positives = 42/90 (46%), Gaps = 29/90 (32%)
Query: 1093 VSRQCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDE 1152
VS +CDG+ DC+ G DE CG ++ C+ D F C
Sbjct: 130 VSWRCDGENDCDSGEDEENCG----NITCSP----------------------DEFTCSS 163
Query: 1153 GLCIAARFVCDGRPQCADGSDE---APAAC 1179
G CI+ FVC+G+ C+DGSDE AP C
Sbjct: 164 GRCISRNFVCNGQDDCSDGSDELDCAPPTC 193
Score = 52.4 bits (120), Expect = 9e-06
Identities = 28/85 (32%), Positives = 37/85 (43%), Gaps = 9/85 (10%)
Query: 1096 QCDGQQ-DCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGL 1154
+C+ Q C +GR C GD C DG+ F C+ G
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESD--------FVCNNGQ 83
Query: 1155 CIAARFVCDGRPQCADGSDEAPAAC 1179
C+ +R+ CDG P C DGSDE+P C
Sbjct: 84 CVPSRWKCDGDPDCEDGSDESPEQC 108
Score = 43.6 bits (98), Expect = 0.004
Identities = 30/99 (30%), Positives = 38/99 (38%), Gaps = 22/99 (22%)
Query: 1097 CDGQQDCEDGRDEAEC-----GA----------------CGGDVRCADGTXXXXXXXXXX 1135
C+GQ DC DG DE +C GA C D C+D +
Sbjct: 173 CNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQ 232
Query: 1136 XXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
+ +C G CI ++ CDG P C DGSDE
Sbjct: 233 PVIHTKCPASE-IQCGSGECIHKKWRCDGDPDCKDGSDE 270
Score = 37.5 bits (83), Expect = 0.29
Identities = 28/99 (28%), Positives = 34/99 (34%), Gaps = 15/99 (15%)
Query: 1096 QCDGQQDCEDGRDEAECGA--CGGD-VRCADGTXXXXXXXXXXXXXXXXXXXX------- 1145
+CDG DC+DG DE C + C D C DG+
Sbjct: 257 RCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVN 316
Query: 1146 -----DAFRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F+C G CI VC+ C D SDE C
Sbjct: 317 QCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKEC 355
Score = 33.1 bits (72), Expect = 6.2
Identities = 12/19 (63%), Positives = 14/19 (73%)
Query: 1094 SRQCDGQQDCEDGRDEAEC 1112
SRQC+G +DC DG DE C
Sbjct: 294 SRQCNGIRDCVDGSDEVNC 312
>L00352-1|AAA56833.1| 860|Homo sapiens low density lipoprotein
receptor protein.
Length = 860
Score = 173 bits (420), Expect = 4e-42
Identities = 105/376 (27%), Positives = 188/376 (50%), Gaps = 20/376 (5%)
Query: 571 DNGGCSHLCFNRPDDYICGCPLGLELTADKKTC--VEPEAFLVYSRKNIIGRLSIKNEYN 628
D CS LC N Y C C G +L K C V A+L ++ ++ + ++++
Sbjct: 360 DPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEY 419
Query: 629 DAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNG----SAVEKIVEW-LGLVE 683
++IP +L+ V AL V+ +++YWSD + I ++ S+ + ++ + +
Sbjct: 420 TSLIP--NLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPD 477
Query: 684 GLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELG 743
GLA+DW NIYWTD+ + V+ G R+ + + KP++IV+DP G+MYW++ G
Sbjct: 478 GLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWG 537
Query: 744 SKS-IKRAAMDGSSV-SVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQT 801
+ + IK+ ++G + S+ E + + + +D +YW + +NG R+T
Sbjct: 538 TPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKT 597
Query: 802 LADN---IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHR 858
+ ++ + P++LA+F D V+W D I A + GS+ + ++L D+ L+H
Sbjct: 598 ILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHN 657
Query: 859 -AKSMGSNQC---GVDNGGCSHLCLPTP--GDVRTDYRCACPAHYRLNKDNITCSEPEEF 912
+ G N C + NGGC +LCLP P + CACP L +D +C E
Sbjct: 658 LTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEA 717
Query: 913 LLFAQKNAVGRIMVAN 928
+ Q+ + R+ V++
Sbjct: 718 AVATQETSTVRLKVSS 733
Score = 172 bits (419), Expect = 6e-42
Identities = 98/314 (31%), Positives = 155/314 (49%), Gaps = 16/314 (5%)
Query: 11 TTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFK-IVSEGLVTPTGI 69
T++ +L A+D N I WSD +I + + + ++S + P G+
Sbjct: 420 TSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGL 479
Query: 70 AIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEI 129
A+DW +YWTD + V RK LF RAI V P G M+WTDWG
Sbjct: 480 AVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTP 539
Query: 130 PKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKR 189
KI++ G+NG +V +NI WPNGIT+D + +YWVD+KL + ID NG RK
Sbjct: 540 AKIKKGGLNG--VDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKT 597
Query: 190 VVKG--GLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYD 247
+++ L +PF+L DK++WTD N +I++ + G + L ++ P D+ ++
Sbjct: 598 ILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSAN-RLTGSDVNLLAENLLSPEDMVLFH 656
Query: 248 ESRQIISAEDYPCKK---NNAGCSHLCL----LSPDPPGYNCACPTGVKLRENSSTTCYD 300
Q C++ +N GC +LCL ++P P + CACP G+ L + +C
Sbjct: 657 NLTQPRGVN--WCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARD-MRSCLT 713
Query: 301 SPQMLLVVAQRSTI 314
+ + + ST+
Sbjct: 714 EAEAAVATQETSTV 727
Score = 164 bits (399), Expect = 1e-39
Identities = 104/376 (27%), Positives = 171/376 (45%), Gaps = 23/376 (6%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDSPDFTP 326
CS LC+ GY C C G +L ++ L R + K++LD +
Sbjct: 364 CSQLCVNLEG--GYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSE--- 418
Query: 327 YTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLD-----GSDQSVVVRSSGVPDS 381
YT + +L+ + +D + + IYW+D + I +LD S +V+ R PD
Sbjct: 419 YTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDG 478
Query: 382 IAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNE 441
+A+D + IYWTD V+ T++VA G K + PRAI + G+M+W+DW
Sbjct: 479 LAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWG- 537
Query: 442 KKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKE 501
KI++ L+G L++E + WPN I LD ++ +LYW D++ H I +++G RK
Sbjct: 538 TPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKT 597
Query: 502 LHSND--IIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAF-R 558
+ ++ + H F + + N+ TG D + E + + + F
Sbjct: 598 ILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHN 657
Query: 559 LGAPLGWNPCAD---DNGGCSHLCFNRPD------DYICGCPLGLELTADKKTCVEPEAF 609
L P G N C NGGC +LC P + C CP G+ L D ++C+
Sbjct: 658 LTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEA 717
Query: 610 LVYSRKNIIGRLSIKN 625
V +++ RL + +
Sbjct: 718 AVATQETSTVRLKVSS 733
Score = 81.4 bits (192), Expect = 2e-14
Identities = 75/297 (25%), Positives = 128/297 (43%), Gaps = 23/297 (7%)
Query: 564 GWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKK-----TCVEPEAFLVYSRKNII 618
G N C D+NGGCSH+C + Y C CP G +L A ++ C +P+ N+
Sbjct: 314 GTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLC-VNLE 372
Query: 619 GRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEW 678
G + E + P K A+ GS Y + + + +++ S ++
Sbjct: 373 GGYKCQCEEGFQLDP--HTKACKAV-----GSIAYLFFTNRHEVRKMTLDRSEYTSLIPN 425
Query: 679 LGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDG----SSRRAIIWQGLKKPKSIVLDPKK 734
L V L + + IYW+D + + I ++LD SS +I + ++ P + +D
Sbjct: 426 LRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIH 485
Query: 735 GYMYWSELGSKSIKRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPV-VEFA 792
+YW++ ++ A G ++F E + A+ +D +YW P ++
Sbjct: 486 SNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKG 545
Query: 793 FLNGTGRQTL-ADNIPMP--YALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKD 846
LNG +L +NI P L L + +YW D I +G NRK+I +D
Sbjct: 546 GLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSI-DVNGGNRKTILED 601
Score = 54.0 bits (124), Expect = 3e-06
Identities = 61/259 (23%), Positives = 104/259 (40%), Gaps = 27/259 (10%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKL----RENSSTTCYDSPQMLLVVAQRSTIS 315
C NN GCSH+C + GY C CP G +L R C D +
Sbjct: 318 CLDNNGGCSHVC--NDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGY 375
Query: 316 KISLDSP-DFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVR 374
K + P+T K + + F + E + K LD S+ + ++
Sbjct: 376 KCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHE-----------VRKMTLDRSEYTSLIP 424
Query: 375 SSGVPDSIAIDPLSRKIYWTDPVMDTINVARLD-----GSYEKVIIHTELYDPRAIALHL 429
+ ++ + S +IYW+D I +LD SY+ +I ++ P +A+
Sbjct: 425 NLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYD-TVISRDIQAPDGLAVDW 483
Query: 430 TAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDART-HK 488
++W+D + A+ G R L E + P +I +D V+ +YW D T K
Sbjct: 484 IHSNIYWTD--SVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAK 541
Query: 489 IEVCNMDGTERKELHSNDI 507
I+ ++G + L + +I
Sbjct: 542 IKKGGLNGVDIYSLVTENI 560
Score = 52.4 bits (120), Expect = 9e-06
Identities = 55/242 (22%), Positives = 92/242 (38%), Gaps = 29/242 (11%)
Query: 860 KSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRL-----NKDNITCSEPEEFLL 914
K G+N+C +NGGCSH+C D++ Y C CP ++L +D C +P+
Sbjct: 311 KECGTNECLDNNGGCSHVC----NDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQ 366
Query: 915 FAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYX 974
N G +C + + K +A V Y + H +R++ +
Sbjct: 367 LC-VNLEGGYKC---QCEEGFQLDPHTKACKA-----VGSIAYLFFTNRHEVRKMTLD-- 415
Query: 975 XXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNN---SSTGVIVRG 1031
L + +V +YW+ + I +T +D SS ++
Sbjct: 416 ----RSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISR 471
Query: 1032 DRMLPRHLAFHQTKRYLIWNDVGRGAIMRANVDGTGRVELARADNA--TALALDQSAGTV 1089
D P LA + W D G + A+ G R L R + + A+ +D G +
Sbjct: 472 DIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFM 531
Query: 1090 YW 1091
YW
Sbjct: 532 YW 533
Score = 52.0 bits (119), Expect = 1e-05
Identities = 46/231 (19%), Positives = 87/231 (37%), Gaps = 14/231 (6%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE--FLLFAQKNAVGRIMVA 927
D CS LC+ G Y+C C ++L+ C +L F ++ V ++ +
Sbjct: 360 DPDTCSQLCVNLEGG----YKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLD 415
Query: 928 NGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXX 987
E + IP L+NV A++ + ++YW D I +
Sbjct: 416 RSEYT-SLIP--NLRNVVALDTEVASNRIYWSDLSQRMICSTQLD-RAHGVSSYDTVISR 471
Query: 988 GLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRY 1047
+ P + +D + +YWT + +++ + R + PR + +
Sbjct: 472 DIQAPDGLAVDWIHSNIYWTDSVLGTVSVAD-TKGVKRKTLFRENGSKPRAIVVDPVHGF 530
Query: 1048 LIWNDVGRGA-IMRANVDGTGRVELARADN--ATALALDQSAGTVYWAVSR 1095
+ W D G A I + ++G L + + LD +G +YW S+
Sbjct: 531 MYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSK 581
Score = 51.2 bits (117), Expect = 2e-05
Identities = 31/97 (31%), Positives = 39/97 (40%), Gaps = 13/97 (13%)
Query: 1096 QCDGQQDCEDGRDEAECG--ACGGD-VRCADG----------TXXXXXXXXXXXXXXXXX 1142
+CDGQ DC++G DE C C D RC DG +
Sbjct: 88 RCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLT 147
Query: 1143 XXXDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
+F+C+ CI + CD P C DGSDE P C
Sbjct: 148 CGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRC 184
Score = 50.0 bits (114), Expect = 5e-05
Identities = 35/97 (36%), Positives = 43/97 (44%), Gaps = 19/97 (19%)
Query: 1097 CDGQQDCEDGRDEAE-------CGA----CGGDV-RC------ADGTXXXXXXXXXXXXX 1138
CDG +C+DG DE++ C + CGG V RC DG
Sbjct: 46 CDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCP 105
Query: 1139 XXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDEA 1175
D FRC +G CI+ +FVCD C DGSDEA
Sbjct: 106 PKTCSQ-DEFRCHDGKCISRQFVCDSDRDCLDGSDEA 141
Score = 46.4 bits (105), Expect = 6e-04
Identities = 16/32 (50%), Positives = 23/32 (71%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F+C +G CI+ ++VCDG +C DGSDE+ C
Sbjct: 32 FQCQDGKCISYKWVCDGSAECQDGSDESQETC 63
Score = 44.0 bits (99), Expect = 0.003
Identities = 37/119 (31%), Positives = 43/119 (36%), Gaps = 25/119 (21%)
Query: 1093 VSRQ--CDGQQDCEDGRDEAECG---------------------ACGGDVRCADGTXXXX 1129
+SRQ CD +DC DG DEA C AC D C DG+
Sbjct: 122 ISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWP 181
Query: 1130 XXXXXXXXXXXXXXXXDAFR--CDEGLCIAARFVCDGRPQCADGSDEAPAACAYGHTDQ 1186
AF C G CI + + CDG P C D SDE A A D+
Sbjct: 182 QRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDE 240
Score = 36.3 bits (80), Expect = 0.66
Identities = 27/118 (22%), Positives = 46/118 (38%), Gaps = 5/118 (4%)
Query: 945 RAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTM 1004
RAI DPV +YW D + + I + P + LD+L +
Sbjct: 520 RAIVVDPVHGFMYWTDWGTPA----KIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRL 575
Query: 1005 YWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGAIMRAN 1062
YW + SI++ + N + I+ ++ L + + + W D+ AI AN
Sbjct: 576 YWVDSKLHSISSIDV-NGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSAN 632
Score = 34.7 bits (76), Expect = 2.0
Identities = 28/100 (28%), Positives = 40/100 (40%), Gaps = 12/100 (12%)
Query: 1078 TALALDQSAGTVYWAVSRQCDGQQ-DCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXX 1136
T L +AGT AV +C+ + C+DG+ + C G C DG+
Sbjct: 11 TVALLLAAAGT---AVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVT 67
Query: 1137 XXXXXXXXXDAFRCDEGL--CIAARFVCDGRPQCADGSDE 1174
F C + CI + CDG+ C +GSDE
Sbjct: 68 CKSGD------FSCGGRVNRCIPQFWRCDGQVDCDNGSDE 101
>BT007361-1|AAP36025.1| 860|Homo sapiens low density lipoprotein
receptor (familial hypercholesterolemia) protein.
Length = 860
Score = 173 bits (420), Expect = 4e-42
Identities = 105/376 (27%), Positives = 188/376 (50%), Gaps = 20/376 (5%)
Query: 571 DNGGCSHLCFNRPDDYICGCPLGLELTADKKTC--VEPEAFLVYSRKNIIGRLSIKNEYN 628
D CS LC N Y C C G +L K C V A+L ++ ++ + ++++
Sbjct: 360 DPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEY 419
Query: 629 DAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNG----SAVEKIVEW-LGLVE 683
++IP +L+ V AL V+ +++YWSD + I ++ S+ + ++ + +
Sbjct: 420 TSLIP--NLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPD 477
Query: 684 GLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELG 743
GLA+DW NIYWTD+ + V+ G R+ + + KP++IV+DP G+MYW++ G
Sbjct: 478 GLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWG 537
Query: 744 SKS-IKRAAMDGSSV-SVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQT 801
+ + IK+ ++G + S+ E + + + +D +YW + +NG R+T
Sbjct: 538 TPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKT 597
Query: 802 LADN---IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHR 858
+ ++ + P++LA+F D V+W D I A + GS+ + ++L D+ L+H
Sbjct: 598 ILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHN 657
Query: 859 -AKSMGSNQC---GVDNGGCSHLCLPTP--GDVRTDYRCACPAHYRLNKDNITCSEPEEF 912
+ G N C + NGGC +LCLP P + CACP L +D +C E
Sbjct: 658 LTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEA 717
Query: 913 LLFAQKNAVGRIMVAN 928
+ Q+ + R+ V++
Sbjct: 718 AVATQETSTVRLKVSS 733
Score = 172 bits (419), Expect = 6e-42
Identities = 98/314 (31%), Positives = 155/314 (49%), Gaps = 16/314 (5%)
Query: 11 TTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFK-IVSEGLVTPTGI 69
T++ +L A+D N I WSD +I + + + ++S + P G+
Sbjct: 420 TSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGL 479
Query: 70 AIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEI 129
A+DW +YWTD + V RK LF RAI V P G M+WTDWG
Sbjct: 480 AVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTP 539
Query: 130 PKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKR 189
KI++ G+NG +V +NI WPNGIT+D + +YWVD+KL + ID NG RK
Sbjct: 540 AKIKKGGLNG--VDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKT 597
Query: 190 VVKG--GLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYD 247
+++ L +PF+L DK++WTD N +I++ + G + L ++ P D+ ++
Sbjct: 598 ILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSAN-RLTGSDVNLLAENLLSPEDMVLFH 656
Query: 248 ESRQIISAEDYPCKK---NNAGCSHLCL----LSPDPPGYNCACPTGVKLRENSSTTCYD 300
Q C++ +N GC +LCL ++P P + CACP G+ L + +C
Sbjct: 657 NLTQPRGVN--WCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARD-MRSCLT 713
Query: 301 SPQMLLVVAQRSTI 314
+ + + ST+
Sbjct: 714 EAEAAVATQETSTV 727
Score = 164 bits (399), Expect = 1e-39
Identities = 104/376 (27%), Positives = 171/376 (45%), Gaps = 23/376 (6%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDSPDFTP 326
CS LC+ GY C C G +L ++ L R + K++LD +
Sbjct: 364 CSQLCVNLEG--GYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSE--- 418
Query: 327 YTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLD-----GSDQSVVVRSSGVPDS 381
YT + +L+ + +D + + IYW+D + I +LD S +V+ R PD
Sbjct: 419 YTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDG 478
Query: 382 IAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNE 441
+A+D + IYWTD V+ T++VA G K + PRAI + G+M+W+DW
Sbjct: 479 LAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWG- 537
Query: 442 KKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKE 501
KI++ L+G L++E + WPN I LD ++ +LYW D++ H I +++G RK
Sbjct: 538 TPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKT 597
Query: 502 LHSND--IIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAF-R 558
+ ++ + H F + + N+ TG D + E + + + F
Sbjct: 598 ILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHN 657
Query: 559 LGAPLGWNPCAD---DNGGCSHLCFNRPD------DYICGCPLGLELTADKKTCVEPEAF 609
L P G N C NGGC +LC P + C CP G+ L D ++C+
Sbjct: 658 LTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEA 717
Query: 610 LVYSRKNIIGRLSIKN 625
V +++ RL + +
Sbjct: 718 AVATQETSTVRLKVSS 733
Score = 81.4 bits (192), Expect = 2e-14
Identities = 75/297 (25%), Positives = 128/297 (43%), Gaps = 23/297 (7%)
Query: 564 GWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKK-----TCVEPEAFLVYSRKNII 618
G N C D+NGGCSH+C + Y C CP G +L A ++ C +P+ N+
Sbjct: 314 GTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLC-VNLE 372
Query: 619 GRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEW 678
G + E + P K A+ GS Y + + + +++ S ++
Sbjct: 373 GGYKCQCEEGFQLDP--HTKACKAV-----GSIAYLFFTNRHEVRKMTLDRSEYTSLIPN 425
Query: 679 LGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDG----SSRRAIIWQGLKKPKSIVLDPKK 734
L V L + + IYW+D + + I ++LD SS +I + ++ P + +D
Sbjct: 426 LRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIH 485
Query: 735 GYMYWSELGSKSIKRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPV-VEFA 792
+YW++ ++ A G ++F E + A+ +D +YW P ++
Sbjct: 486 SNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKG 545
Query: 793 FLNGTGRQTL-ADNIPMP--YALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKD 846
LNG +L +NI P L L + +YW D I +G NRK+I +D
Sbjct: 546 GLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSI-DVNGGNRKTILED 601
Score = 54.0 bits (124), Expect = 3e-06
Identities = 61/259 (23%), Positives = 104/259 (40%), Gaps = 27/259 (10%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKL----RENSSTTCYDSPQMLLVVAQRSTIS 315
C NN GCSH+C + GY C CP G +L R C D +
Sbjct: 318 CLDNNGGCSHVC--NDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGY 375
Query: 316 KISLDSP-DFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVR 374
K + P+T K + + F + E + K LD S+ + ++
Sbjct: 376 KCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHE-----------VRKMTLDRSEYTSLIP 424
Query: 375 SSGVPDSIAIDPLSRKIYWTDPVMDTINVARLD-----GSYEKVIIHTELYDPRAIALHL 429
+ ++ + S +IYW+D I +LD SY+ +I ++ P +A+
Sbjct: 425 NLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYD-TVISRDIQAPDGLAVDW 483
Query: 430 TAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDART-HK 488
++W+D + A+ G R L E + P +I +D V+ +YW D T K
Sbjct: 484 IHSNIYWTD--SVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAK 541
Query: 489 IEVCNMDGTERKELHSNDI 507
I+ ++G + L + +I
Sbjct: 542 IKKGGLNGVDIYSLVTENI 560
Score = 52.4 bits (120), Expect = 9e-06
Identities = 55/242 (22%), Positives = 92/242 (38%), Gaps = 29/242 (11%)
Query: 860 KSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRL-----NKDNITCSEPEEFLL 914
K G+N+C +NGGCSH+C D++ Y C CP ++L +D C +P+
Sbjct: 311 KECGTNECLDNNGGCSHVC----NDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQ 366
Query: 915 FAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYX 974
N G +C + + K +A V Y + H +R++ +
Sbjct: 367 LC-VNLEGGYKC---QCEEGFQLDPHTKACKA-----VGSIAYLFFTNRHEVRKMTLD-- 415
Query: 975 XXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNN---SSTGVIVRG 1031
L + +V +YW+ + I +T +D SS ++
Sbjct: 416 ----RSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISR 471
Query: 1032 DRMLPRHLAFHQTKRYLIWNDVGRGAIMRANVDGTGRVELARADNA--TALALDQSAGTV 1089
D P LA + W D G + A+ G R L R + + A+ +D G +
Sbjct: 472 DIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFM 531
Query: 1090 YW 1091
YW
Sbjct: 532 YW 533
Score = 52.0 bits (119), Expect = 1e-05
Identities = 46/231 (19%), Positives = 87/231 (37%), Gaps = 14/231 (6%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE--FLLFAQKNAVGRIMVA 927
D CS LC+ G Y+C C ++L+ C +L F ++ V ++ +
Sbjct: 360 DPDTCSQLCVNLEGG----YKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLD 415
Query: 928 NGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXX 987
E + IP L+NV A++ + ++YW D I +
Sbjct: 416 RSEYT-SLIP--NLRNVVALDTEVASNRIYWSDLSQRMICSTQLD-RAHGVSSYDTVISR 471
Query: 988 GLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRY 1047
+ P + +D + +YWT + +++ + R + PR + +
Sbjct: 472 DIQAPDGLAVDWIHSNIYWTDSVLGTVSVAD-TKGVKRKTLFRENGSKPRAIVVDPVHGF 530
Query: 1048 LIWNDVGRGA-IMRANVDGTGRVELARADN--ATALALDQSAGTVYWAVSR 1095
+ W D G A I + ++G L + + LD +G +YW S+
Sbjct: 531 MYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSK 581
Score = 51.2 bits (117), Expect = 2e-05
Identities = 31/97 (31%), Positives = 39/97 (40%), Gaps = 13/97 (13%)
Query: 1096 QCDGQQDCEDGRDEAECG--ACGGD-VRCADG----------TXXXXXXXXXXXXXXXXX 1142
+CDGQ DC++G DE C C D RC DG +
Sbjct: 88 RCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLT 147
Query: 1143 XXXDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
+F+C+ CI + CD P C DGSDE P C
Sbjct: 148 CGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRC 184
Score = 50.0 bits (114), Expect = 5e-05
Identities = 35/97 (36%), Positives = 43/97 (44%), Gaps = 19/97 (19%)
Query: 1097 CDGQQDCEDGRDEAE-------CGA----CGGDV-RC------ADGTXXXXXXXXXXXXX 1138
CDG +C+DG DE++ C + CGG V RC DG
Sbjct: 46 CDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCP 105
Query: 1139 XXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDEA 1175
D FRC +G CI+ +FVCD C DGSDEA
Sbjct: 106 PKTCSQ-DEFRCHDGKCISRQFVCDSDRDCLDGSDEA 141
Score = 46.4 bits (105), Expect = 6e-04
Identities = 16/32 (50%), Positives = 23/32 (71%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F+C +G CI+ ++VCDG +C DGSDE+ C
Sbjct: 32 FQCQDGKCISYKWVCDGSAECQDGSDESQETC 63
Score = 44.0 bits (99), Expect = 0.003
Identities = 37/119 (31%), Positives = 43/119 (36%), Gaps = 25/119 (21%)
Query: 1093 VSRQ--CDGQQDCEDGRDEAECG---------------------ACGGDVRCADGTXXXX 1129
+SRQ CD +DC DG DEA C AC D C DG+
Sbjct: 122 ISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWP 181
Query: 1130 XXXXXXXXXXXXXXXXDAFR--CDEGLCIAARFVCDGRPQCADGSDEAPAACAYGHTDQ 1186
AF C G CI + + CDG P C D SDE A A D+
Sbjct: 182 QRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDE 240
Score = 36.3 bits (80), Expect = 0.66
Identities = 27/118 (22%), Positives = 46/118 (38%), Gaps = 5/118 (4%)
Query: 945 RAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTM 1004
RAI DPV +YW D + + I + P + LD+L +
Sbjct: 520 RAIVVDPVHGFMYWTDWGTPA----KIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRL 575
Query: 1005 YWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGAIMRAN 1062
YW + SI++ + N + I+ ++ L + + + W D+ AI AN
Sbjct: 576 YWVDSKLHSISSIDV-NGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSAN 632
Score = 34.7 bits (76), Expect = 2.0
Identities = 28/100 (28%), Positives = 40/100 (40%), Gaps = 12/100 (12%)
Query: 1078 TALALDQSAGTVYWAVSRQCDGQQ-DCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXX 1136
T L +AGT AV +C+ + C+DG+ + C G C DG+
Sbjct: 11 TVALLLAAAGT---AVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVT 67
Query: 1137 XXXXXXXXXDAFRCDEGL--CIAARFVCDGRPQCADGSDE 1174
F C + CI + CDG+ C +GSDE
Sbjct: 68 CKSGD------FSCGGRVNRCIPQFWRCDGQVDCDNGSDE 101
>BC014514-1|AAH14514.1| 860|Homo sapiens low density lipoprotein
receptor (familial hypercholesterolemia) protein.
Length = 860
Score = 173 bits (420), Expect = 4e-42
Identities = 105/376 (27%), Positives = 188/376 (50%), Gaps = 20/376 (5%)
Query: 571 DNGGCSHLCFNRPDDYICGCPLGLELTADKKTC--VEPEAFLVYSRKNIIGRLSIKNEYN 628
D CS LC N Y C C G +L K C V A+L ++ ++ + ++++
Sbjct: 360 DPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEY 419
Query: 629 DAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNG----SAVEKIVEW-LGLVE 683
++IP +L+ V AL V+ +++YWSD + I ++ S+ + ++ + +
Sbjct: 420 TSLIP--NLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPD 477
Query: 684 GLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELG 743
GLA+DW NIYWTD+ + V+ G R+ + + KP++IV+DP G+MYW++ G
Sbjct: 478 GLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWG 537
Query: 744 SKS-IKRAAMDGSSV-SVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQT 801
+ + IK+ ++G + S+ E + + + +D +YW + +NG R+T
Sbjct: 538 TPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKT 597
Query: 802 LADN---IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHR 858
+ ++ + P++LA+F D V+W D I A + GS+ + ++L D+ L+H
Sbjct: 598 ILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHN 657
Query: 859 -AKSMGSNQC---GVDNGGCSHLCLPTP--GDVRTDYRCACPAHYRLNKDNITCSEPEEF 912
+ G N C + NGGC +LCLP P + CACP L +D +C E
Sbjct: 658 LTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEA 717
Query: 913 LLFAQKNAVGRIMVAN 928
+ Q+ + R+ V++
Sbjct: 718 AVATQETSTVRLKVSS 733
Score = 172 bits (419), Expect = 6e-42
Identities = 98/314 (31%), Positives = 155/314 (49%), Gaps = 16/314 (5%)
Query: 11 TTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFK-IVSEGLVTPTGI 69
T++ +L A+D N I WSD +I + + + ++S + P G+
Sbjct: 420 TSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGL 479
Query: 70 AIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEI 129
A+DW +YWTD + V RK LF RAI V P G M+WTDWG
Sbjct: 480 AVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTP 539
Query: 130 PKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKR 189
KI++ G+NG +V +NI WPNGIT+D + +YWVD+KL + ID NG RK
Sbjct: 540 AKIKKGGLNG--VDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKT 597
Query: 190 VVKG--GLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYD 247
+++ L +PF+L DK++WTD N +I++ + G + L ++ P D+ ++
Sbjct: 598 ILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSAN-RLTGSDVNLLAENLLSPEDMVLFH 656
Query: 248 ESRQIISAEDYPCKK---NNAGCSHLCL----LSPDPPGYNCACPTGVKLRENSSTTCYD 300
Q C++ +N GC +LCL ++P P + CACP G+ L + +C
Sbjct: 657 NLTQPRGVN--WCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARD-MRSCLT 713
Query: 301 SPQMLLVVAQRSTI 314
+ + + ST+
Sbjct: 714 EAEAAVATQETSTV 727
Score = 164 bits (399), Expect = 1e-39
Identities = 104/376 (27%), Positives = 171/376 (45%), Gaps = 23/376 (6%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDSPDFTP 326
CS LC+ GY C C G +L ++ L R + K++LD +
Sbjct: 364 CSQLCVNLEG--GYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSE--- 418
Query: 327 YTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLD-----GSDQSVVVRSSGVPDS 381
YT + +L+ + +D + + IYW+D + I +LD S +V+ R PD
Sbjct: 419 YTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDG 478
Query: 382 IAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNE 441
+A+D + IYWTD V+ T++VA G K + PRAI + G+M+W+DW
Sbjct: 479 LAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWG- 537
Query: 442 KKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKE 501
KI++ L+G L++E + WPN I LD ++ +LYW D++ H I +++G RK
Sbjct: 538 TPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKT 597
Query: 502 LHSND--IIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAF-R 558
+ ++ + H F + + N+ TG D + E + + + F
Sbjct: 598 ILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHN 657
Query: 559 LGAPLGWNPCAD---DNGGCSHLCFNRPD------DYICGCPLGLELTADKKTCVEPEAF 609
L P G N C NGGC +LC P + C CP G+ L D ++C+
Sbjct: 658 LTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEA 717
Query: 610 LVYSRKNIIGRLSIKN 625
V +++ RL + +
Sbjct: 718 AVATQETSTVRLKVSS 733
Score = 81.4 bits (192), Expect = 2e-14
Identities = 75/297 (25%), Positives = 128/297 (43%), Gaps = 23/297 (7%)
Query: 564 GWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKK-----TCVEPEAFLVYSRKNII 618
G N C D+NGGCSH+C + Y C CP G +L A ++ C +P+ N+
Sbjct: 314 GTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLC-VNLE 372
Query: 619 GRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEW 678
G + E + P K A+ GS Y + + + +++ S ++
Sbjct: 373 GGYKCQCEEGFQLDP--HTKACKAV-----GSIAYLFFTNRHEVRKMTLDRSEYTSLIPN 425
Query: 679 LGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDG----SSRRAIIWQGLKKPKSIVLDPKK 734
L V L + + IYW+D + + I ++LD SS +I + ++ P + +D
Sbjct: 426 LRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIH 485
Query: 735 GYMYWSELGSKSIKRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPV-VEFA 792
+YW++ ++ A G ++F E + A+ +D +YW P ++
Sbjct: 486 SNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKG 545
Query: 793 FLNGTGRQTL-ADNIPMP--YALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKD 846
LNG +L +NI P L L + +YW D I +G NRK+I +D
Sbjct: 546 GLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSI-DVNGGNRKTILED 601
Score = 54.0 bits (124), Expect = 3e-06
Identities = 61/259 (23%), Positives = 104/259 (40%), Gaps = 27/259 (10%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKL----RENSSTTCYDSPQMLLVVAQRSTIS 315
C NN GCSH+C + GY C CP G +L R C D +
Sbjct: 318 CLDNNGGCSHVC--NDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGY 375
Query: 316 KISLDSP-DFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVR 374
K + P+T K + + F + E + K LD S+ + ++
Sbjct: 376 KCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHE-----------VRKMTLDRSEYTSLIP 424
Query: 375 SSGVPDSIAIDPLSRKIYWTDPVMDTINVARLD-----GSYEKVIIHTELYDPRAIALHL 429
+ ++ + S +IYW+D I +LD SY+ +I ++ P +A+
Sbjct: 425 NLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYD-TVISRDIQAPDGLAVDW 483
Query: 430 TAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDART-HK 488
++W+D + A+ G R L E + P +I +D V+ +YW D T K
Sbjct: 484 IHSNIYWTD--SVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAK 541
Query: 489 IEVCNMDGTERKELHSNDI 507
I+ ++G + L + +I
Sbjct: 542 IKKGGLNGVDIYSLVTENI 560
Score = 52.4 bits (120), Expect = 9e-06
Identities = 55/242 (22%), Positives = 92/242 (38%), Gaps = 29/242 (11%)
Query: 860 KSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRL-----NKDNITCSEPEEFLL 914
K G+N+C +NGGCSH+C D++ Y C CP ++L +D C +P+
Sbjct: 311 KECGTNECLDNNGGCSHVC----NDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQ 366
Query: 915 FAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYX 974
N G +C + + K +A V Y + H +R++ +
Sbjct: 367 LC-VNLEGGYKC---QCEEGFQLDPHTKACKA-----VGSIAYLFFTNRHEVRKMTLD-- 415
Query: 975 XXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNN---SSTGVIVRG 1031
L + +V +YW+ + I +T +D SS ++
Sbjct: 416 ----RSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISR 471
Query: 1032 DRMLPRHLAFHQTKRYLIWNDVGRGAIMRANVDGTGRVELARADNA--TALALDQSAGTV 1089
D P LA + W D G + A+ G R L R + + A+ +D G +
Sbjct: 472 DIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFM 531
Query: 1090 YW 1091
YW
Sbjct: 532 YW 533
Score = 52.0 bits (119), Expect = 1e-05
Identities = 46/231 (19%), Positives = 87/231 (37%), Gaps = 14/231 (6%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE--FLLFAQKNAVGRIMVA 927
D CS LC+ G Y+C C ++L+ C +L F ++ V ++ +
Sbjct: 360 DPDTCSQLCVNLEGG----YKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLD 415
Query: 928 NGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXX 987
E + IP L+NV A++ + ++YW D I +
Sbjct: 416 RSEYT-SLIP--NLRNVVALDTEVASNRIYWSDLSQRMICSTQLD-RAHGVSSYDTVISR 471
Query: 988 GLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRY 1047
+ P + +D + +YWT + +++ + R + PR + +
Sbjct: 472 DIQAPDGLAVDWIHSNIYWTDSVLGTVSVAD-TKGVKRKTLFRENGSKPRAIVVDPVHGF 530
Query: 1048 LIWNDVGRGA-IMRANVDGTGRVELARADN--ATALALDQSAGTVYWAVSR 1095
+ W D G A I + ++G L + + LD +G +YW S+
Sbjct: 531 MYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSK 581
Score = 51.2 bits (117), Expect = 2e-05
Identities = 31/97 (31%), Positives = 39/97 (40%), Gaps = 13/97 (13%)
Query: 1096 QCDGQQDCEDGRDEAECG--ACGGD-VRCADG----------TXXXXXXXXXXXXXXXXX 1142
+CDGQ DC++G DE C C D RC DG +
Sbjct: 88 RCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLT 147
Query: 1143 XXXDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
+F+C+ CI + CD P C DGSDE P C
Sbjct: 148 CGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRC 184
Score = 50.0 bits (114), Expect = 5e-05
Identities = 35/97 (36%), Positives = 43/97 (44%), Gaps = 19/97 (19%)
Query: 1097 CDGQQDCEDGRDEAE-------CGA----CGGDV-RC------ADGTXXXXXXXXXXXXX 1138
CDG +C+DG DE++ C + CGG V RC DG
Sbjct: 46 CDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCP 105
Query: 1139 XXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDEA 1175
D FRC +G CI+ +FVCD C DGSDEA
Sbjct: 106 PKTCSQ-DEFRCHDGKCISRQFVCDSDRDCLDGSDEA 141
Score = 46.4 bits (105), Expect = 6e-04
Identities = 16/32 (50%), Positives = 23/32 (71%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F+C +G CI+ ++VCDG +C DGSDE+ C
Sbjct: 32 FQCQDGKCISYKWVCDGSAECQDGSDESQETC 63
Score = 44.0 bits (99), Expect = 0.003
Identities = 37/119 (31%), Positives = 43/119 (36%), Gaps = 25/119 (21%)
Query: 1093 VSRQ--CDGQQDCEDGRDEAECG---------------------ACGGDVRCADGTXXXX 1129
+SRQ CD +DC DG DEA C AC D C DG+
Sbjct: 122 ISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWP 181
Query: 1130 XXXXXXXXXXXXXXXXDAFR--CDEGLCIAARFVCDGRPQCADGSDEAPAACAYGHTDQ 1186
AF C G CI + + CDG P C D SDE A A D+
Sbjct: 182 QRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDE 240
Score = 36.3 bits (80), Expect = 0.66
Identities = 27/118 (22%), Positives = 46/118 (38%), Gaps = 5/118 (4%)
Query: 945 RAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTM 1004
RAI DPV +YW D + + I + P + LD+L +
Sbjct: 520 RAIVVDPVHGFMYWTDWGTPA----KIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRL 575
Query: 1005 YWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGAIMRAN 1062
YW + SI++ + N + I+ ++ L + + + W D+ AI AN
Sbjct: 576 YWVDSKLHSISSIDV-NGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSAN 632
Score = 34.7 bits (76), Expect = 2.0
Identities = 28/100 (28%), Positives = 40/100 (40%), Gaps = 12/100 (12%)
Query: 1078 TALALDQSAGTVYWAVSRQCDGQQ-DCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXX 1136
T L +AGT AV +C+ + C+DG+ + C G C DG+
Sbjct: 11 TVALLLAAAGT---AVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVT 67
Query: 1137 XXXXXXXXXDAFRCDEGL--CIAARFVCDGRPQCADGSDE 1174
F C + CI + CDG+ C +GSDE
Sbjct: 68 CKSGD------FSCGGRVNRCIPQFWRCDGQVDCDNGSDE 101
>AY324609-1|AAP72971.1| 860|Homo sapiens low density lipoprotein
receptor protein.
Length = 860
Score = 173 bits (420), Expect = 4e-42
Identities = 105/376 (27%), Positives = 188/376 (50%), Gaps = 20/376 (5%)
Query: 571 DNGGCSHLCFNRPDDYICGCPLGLELTADKKTC--VEPEAFLVYSRKNIIGRLSIKNEYN 628
D CS LC N Y C C G +L K C V A+L ++ ++ + ++++
Sbjct: 360 DPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEY 419
Query: 629 DAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNG----SAVEKIVEW-LGLVE 683
++IP +L+ V AL V+ +++YWSD + I ++ S+ + ++ + +
Sbjct: 420 TSLIP--NLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPD 477
Query: 684 GLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELG 743
GLA+DW NIYWTD+ + V+ G R+ + + KP++IV+DP G+MYW++ G
Sbjct: 478 GLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWG 537
Query: 744 SKS-IKRAAMDGSSV-SVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQT 801
+ + IK+ ++G + S+ E + + + +D +YW + +NG R+T
Sbjct: 538 TPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKT 597
Query: 802 LADN---IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHR 858
+ ++ + P++LA+F D V+W D I A + GS+ + ++L D+ L+H
Sbjct: 598 ILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHN 657
Query: 859 -AKSMGSNQC---GVDNGGCSHLCLPTP--GDVRTDYRCACPAHYRLNKDNITCSEPEEF 912
+ G N C + NGGC +LCLP P + CACP L +D +C E
Sbjct: 658 LTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEA 717
Query: 913 LLFAQKNAVGRIMVAN 928
+ Q+ + R+ V++
Sbjct: 718 AVATQETSTVRLKVSS 733
Score = 172 bits (419), Expect = 6e-42
Identities = 98/314 (31%), Positives = 155/314 (49%), Gaps = 16/314 (5%)
Query: 11 TTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFK-IVSEGLVTPTGI 69
T++ +L A+D N I WSD +I + + + ++S + P G+
Sbjct: 420 TSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGL 479
Query: 70 AIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEI 129
A+DW +YWTD + V RK LF RAI V P G M+WTDWG
Sbjct: 480 AVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTP 539
Query: 130 PKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKR 189
KI++ G+NG +V +NI WPNGIT+D + +YWVD+KL + ID NG RK
Sbjct: 540 AKIKKGGLNG--VDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKT 597
Query: 190 VVKG--GLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYD 247
+++ L +PF+L DK++WTD N +I++ + G + L ++ P D+ ++
Sbjct: 598 ILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSAN-RLTGSDVNLLAENLLSPEDMVLFH 656
Query: 248 ESRQIISAEDYPCKK---NNAGCSHLCL----LSPDPPGYNCACPTGVKLRENSSTTCYD 300
Q C++ +N GC +LCL ++P P + CACP G+ L + +C
Sbjct: 657 NLTQPRGVN--WCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARD-MRSCLT 713
Query: 301 SPQMLLVVAQRSTI 314
+ + + ST+
Sbjct: 714 EAEAAVATQETSTV 727
Score = 164 bits (399), Expect = 1e-39
Identities = 104/376 (27%), Positives = 171/376 (45%), Gaps = 23/376 (6%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDSPDFTP 326
CS LC+ GY C C G +L ++ L R + K++LD +
Sbjct: 364 CSQLCVNLEG--GYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSE--- 418
Query: 327 YTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLD-----GSDQSVVVRSSGVPDS 381
YT + +L+ + +D + + IYW+D + I +LD S +V+ R PD
Sbjct: 419 YTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDG 478
Query: 382 IAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNE 441
+A+D + IYWTD V+ T++VA G K + PRAI + G+M+W+DW
Sbjct: 479 LAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWG- 537
Query: 442 KKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKE 501
KI++ L+G L++E + WPN I LD ++ +LYW D++ H I +++G RK
Sbjct: 538 TPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKT 597
Query: 502 LHSND--IIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAF-R 558
+ ++ + H F + + N+ TG D + E + + + F
Sbjct: 598 ILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHN 657
Query: 559 LGAPLGWNPCAD---DNGGCSHLCFNRPD------DYICGCPLGLELTADKKTCVEPEAF 609
L P G N C NGGC +LC P + C CP G+ L D ++C+
Sbjct: 658 LTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEA 717
Query: 610 LVYSRKNIIGRLSIKN 625
V +++ RL + +
Sbjct: 718 AVATQETSTVRLKVSS 733
Score = 81.4 bits (192), Expect = 2e-14
Identities = 75/297 (25%), Positives = 128/297 (43%), Gaps = 23/297 (7%)
Query: 564 GWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKK-----TCVEPEAFLVYSRKNII 618
G N C D+NGGCSH+C + Y C CP G +L A ++ C +P+ N+
Sbjct: 314 GTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLC-VNLE 372
Query: 619 GRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEW 678
G + E + P K A+ GS Y + + + +++ S ++
Sbjct: 373 GGYKCQCEEGFQLDP--HTKACKAV-----GSIAYLFFTNRHEVRKMTLDRSEYTSLIPN 425
Query: 679 LGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDG----SSRRAIIWQGLKKPKSIVLDPKK 734
L V L + + IYW+D + + I ++LD SS +I + ++ P + +D
Sbjct: 426 LRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIH 485
Query: 735 GYMYWSELGSKSIKRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPV-VEFA 792
+YW++ ++ A G ++F E + A+ +D +YW P ++
Sbjct: 486 SNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKG 545
Query: 793 FLNGTGRQTL-ADNIPMP--YALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKD 846
LNG +L +NI P L L + +YW D I +G NRK+I +D
Sbjct: 546 GLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSI-DVNGGNRKTILED 601
Score = 54.0 bits (124), Expect = 3e-06
Identities = 61/259 (23%), Positives = 104/259 (40%), Gaps = 27/259 (10%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKL----RENSSTTCYDSPQMLLVVAQRSTIS 315
C NN GCSH+C + GY C CP G +L R C D +
Sbjct: 318 CLDNNGGCSHVC--NDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGY 375
Query: 316 KISLDSP-DFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVR 374
K + P+T K + + F + E + K LD S+ + ++
Sbjct: 376 KCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHE-----------VRKMTLDRSEYTSLIP 424
Query: 375 SSGVPDSIAIDPLSRKIYWTDPVMDTINVARLD-----GSYEKVIIHTELYDPRAIALHL 429
+ ++ + S +IYW+D I +LD SY+ +I ++ P +A+
Sbjct: 425 NLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYD-TVISRDIQAPDGLAVDW 483
Query: 430 TAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDART-HK 488
++W+D + A+ G R L E + P +I +D V+ +YW D T K
Sbjct: 484 IHSNIYWTD--SVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAK 541
Query: 489 IEVCNMDGTERKELHSNDI 507
I+ ++G + L + +I
Sbjct: 542 IKKGGLNGVDIYSLVTENI 560
Score = 52.4 bits (120), Expect = 9e-06
Identities = 55/242 (22%), Positives = 92/242 (38%), Gaps = 29/242 (11%)
Query: 860 KSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRL-----NKDNITCSEPEEFLL 914
K G+N+C +NGGCSH+C D++ Y C CP ++L +D C +P+
Sbjct: 311 KECGTNECLDNNGGCSHVC----NDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQ 366
Query: 915 FAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYX 974
N G +C + + K +A V Y + H +R++ +
Sbjct: 367 LC-VNLEGGYKC---QCEEGFQLDPHTKACKA-----VGSIAYLFFTNRHEVRKMTLD-- 415
Query: 975 XXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNN---SSTGVIVRG 1031
L + +V +YW+ + I +T +D SS ++
Sbjct: 416 ----RSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISR 471
Query: 1032 DRMLPRHLAFHQTKRYLIWNDVGRGAIMRANVDGTGRVELARADNA--TALALDQSAGTV 1089
D P LA + W D G + A+ G R L R + + A+ +D G +
Sbjct: 472 DIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFM 531
Query: 1090 YW 1091
YW
Sbjct: 532 YW 533
Score = 52.0 bits (119), Expect = 1e-05
Identities = 46/231 (19%), Positives = 87/231 (37%), Gaps = 14/231 (6%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE--FLLFAQKNAVGRIMVA 927
D CS LC+ G Y+C C ++L+ C +L F ++ V ++ +
Sbjct: 360 DPDTCSQLCVNLEGG----YKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLD 415
Query: 928 NGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXX 987
E + IP L+NV A++ + ++YW D I +
Sbjct: 416 RSEYT-SLIP--NLRNVVALDTEVASNRIYWSDLSQRMICSTQLD-RAHGVSSYDTVISR 471
Query: 988 GLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRY 1047
+ P + +D + +YWT + +++ + R + PR + +
Sbjct: 472 DIQAPDGLAVDWIHSNIYWTDSVLGTVSVAD-TKGVKRKTLFRENGSKPRAIVVDPVHGF 530
Query: 1048 LIWNDVGRGA-IMRANVDGTGRVELARADN--ATALALDQSAGTVYWAVSR 1095
+ W D G A I + ++G L + + LD +G +YW S+
Sbjct: 531 MYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSK 581
Score = 51.2 bits (117), Expect = 2e-05
Identities = 31/97 (31%), Positives = 39/97 (40%), Gaps = 13/97 (13%)
Query: 1096 QCDGQQDCEDGRDEAECG--ACGGD-VRCADG----------TXXXXXXXXXXXXXXXXX 1142
+CDGQ DC++G DE C C D RC DG +
Sbjct: 88 RCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLT 147
Query: 1143 XXXDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
+F+C+ CI + CD P C DGSDE P C
Sbjct: 148 CGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRC 184
Score = 50.0 bits (114), Expect = 5e-05
Identities = 35/97 (36%), Positives = 43/97 (44%), Gaps = 19/97 (19%)
Query: 1097 CDGQQDCEDGRDEAE-------CGA----CGGDV-RC------ADGTXXXXXXXXXXXXX 1138
CDG +C+DG DE++ C + CGG V RC DG
Sbjct: 46 CDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCP 105
Query: 1139 XXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDEA 1175
D FRC +G CI+ +FVCD C DGSDEA
Sbjct: 106 PKTCSQ-DEFRCHDGKCISRQFVCDSDRDCLDGSDEA 141
Score = 46.4 bits (105), Expect = 6e-04
Identities = 16/32 (50%), Positives = 23/32 (71%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F+C +G CI+ ++VCDG +C DGSDE+ C
Sbjct: 32 FQCQDGKCISYKWVCDGSAECQDGSDESQETC 63
Score = 44.0 bits (99), Expect = 0.003
Identities = 37/119 (31%), Positives = 43/119 (36%), Gaps = 25/119 (21%)
Query: 1093 VSRQ--CDGQQDCEDGRDEAECG---------------------ACGGDVRCADGTXXXX 1129
+SRQ CD +DC DG DEA C AC D C DG+
Sbjct: 122 ISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWP 181
Query: 1130 XXXXXXXXXXXXXXXXDAFR--CDEGLCIAARFVCDGRPQCADGSDEAPAACAYGHTDQ 1186
AF C G CI + + CDG P C D SDE A A D+
Sbjct: 182 QRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDE 240
Score = 36.3 bits (80), Expect = 0.66
Identities = 27/118 (22%), Positives = 46/118 (38%), Gaps = 5/118 (4%)
Query: 945 RAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTM 1004
RAI DPV +YW D + + I + P + LD+L +
Sbjct: 520 RAIVVDPVHGFMYWTDWGTPA----KIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRL 575
Query: 1005 YWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGAIMRAN 1062
YW + SI++ + N + I+ ++ L + + + W D+ AI AN
Sbjct: 576 YWVDSKLHSISSIDV-NGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSAN 632
Score = 34.7 bits (76), Expect = 2.0
Identities = 28/100 (28%), Positives = 40/100 (40%), Gaps = 12/100 (12%)
Query: 1078 TALALDQSAGTVYWAVSRQCDGQQ-DCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXX 1136
T L +AGT AV +C+ + C+DG+ + C G C DG+
Sbjct: 11 TVALLLAAAGT---AVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVT 67
Query: 1137 XXXXXXXXXDAFRCDEGL--CIAARFVCDGRPQCADGSDE 1174
F C + CI + CDG+ C +GSDE
Sbjct: 68 CKSGD------FSCGGRVNRCIPQFWRCDGQVDCDNGSDE 101
>AY114155-1|AAM56036.1| 860|Homo sapiens low density lipoprotein
receptor protein.
Length = 860
Score = 173 bits (420), Expect = 4e-42
Identities = 105/376 (27%), Positives = 188/376 (50%), Gaps = 20/376 (5%)
Query: 571 DNGGCSHLCFNRPDDYICGCPLGLELTADKKTC--VEPEAFLVYSRKNIIGRLSIKNEYN 628
D CS LC N Y C C G +L K C V A+L ++ ++ + ++++
Sbjct: 360 DPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEY 419
Query: 629 DAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNG----SAVEKIVEW-LGLVE 683
++IP +L+ V AL V+ +++YWSD + I ++ S+ + ++ + +
Sbjct: 420 TSLIP--NLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPD 477
Query: 684 GLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELG 743
GLA+DW NIYWTD+ + V+ G R+ + + KP++IV+DP G+MYW++ G
Sbjct: 478 GLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWG 537
Query: 744 SKS-IKRAAMDGSSV-SVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQT 801
+ + IK+ ++G + S+ E + + + +D +YW + +NG R+T
Sbjct: 538 TPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKT 597
Query: 802 LADN---IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHR 858
+ ++ + P++LA+F D V+W D I A + GS+ + ++L D+ L+H
Sbjct: 598 ILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHN 657
Query: 859 -AKSMGSNQC---GVDNGGCSHLCLPTP--GDVRTDYRCACPAHYRLNKDNITCSEPEEF 912
+ G N C + NGGC +LCLP P + CACP L +D +C E
Sbjct: 658 LTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEA 717
Query: 913 LLFAQKNAVGRIMVAN 928
+ Q+ + R+ V++
Sbjct: 718 AVATQETSTVRLKVSS 733
Score = 172 bits (419), Expect = 6e-42
Identities = 98/314 (31%), Positives = 155/314 (49%), Gaps = 16/314 (5%)
Query: 11 TTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFK-IVSEGLVTPTGI 69
T++ +L A+D N I WSD +I + + + ++S + P G+
Sbjct: 420 TSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGL 479
Query: 70 AIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEI 129
A+DW +YWTD + V RK LF RAI V P G M+WTDWG
Sbjct: 480 AVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTP 539
Query: 130 PKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKR 189
KI++ G+NG +V +NI WPNGIT+D + +YWVD+KL + ID NG RK
Sbjct: 540 AKIKKGGLNG--VDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKT 597
Query: 190 VVKG--GLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYD 247
+++ L +PF+L DK++WTD N +I++ + G + L ++ P D+ ++
Sbjct: 598 ILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSAN-RLTGSDVNLLAENLLSPEDMVLFH 656
Query: 248 ESRQIISAEDYPCKK---NNAGCSHLCL----LSPDPPGYNCACPTGVKLRENSSTTCYD 300
Q C++ +N GC +LCL ++P P + CACP G+ L + +C
Sbjct: 657 NLTQPRGVN--WCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARD-MRSCLT 713
Query: 301 SPQMLLVVAQRSTI 314
+ + + ST+
Sbjct: 714 EAEAAVATQETSTV 727
Score = 164 bits (399), Expect = 1e-39
Identities = 104/376 (27%), Positives = 171/376 (45%), Gaps = 23/376 (6%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDSPDFTP 326
CS LC+ GY C C G +L ++ L R + K++LD +
Sbjct: 364 CSQLCVNLEG--GYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSE--- 418
Query: 327 YTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLD-----GSDQSVVVRSSGVPDS 381
YT + +L+ + +D + + IYW+D + I +LD S +V+ R PD
Sbjct: 419 YTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDG 478
Query: 382 IAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNE 441
+A+D + IYWTD V+ T++VA G K + PRAI + G+M+W+DW
Sbjct: 479 LAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWG- 537
Query: 442 KKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKE 501
KI++ L+G L++E + WPN I LD ++ +LYW D++ H I +++G RK
Sbjct: 538 TPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKT 597
Query: 502 LHSND--IIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAF-R 558
+ ++ + H F + + N+ TG D + E + + + F
Sbjct: 598 ILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHN 657
Query: 559 LGAPLGWNPCAD---DNGGCSHLCFNRPD------DYICGCPLGLELTADKKTCVEPEAF 609
L P G N C NGGC +LC P + C CP G+ L D ++C+
Sbjct: 658 LTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEA 717
Query: 610 LVYSRKNIIGRLSIKN 625
V +++ RL + +
Sbjct: 718 AVATQETSTVRLKVSS 733
Score = 81.4 bits (192), Expect = 2e-14
Identities = 75/297 (25%), Positives = 128/297 (43%), Gaps = 23/297 (7%)
Query: 564 GWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKK-----TCVEPEAFLVYSRKNII 618
G N C D+NGGCSH+C + Y C CP G +L A ++ C +P+ N+
Sbjct: 314 GTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLC-VNLE 372
Query: 619 GRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEW 678
G + E + P K A+ GS Y + + + +++ S ++
Sbjct: 373 GGYKCQCEEGFQLDP--HTKACKAV-----GSIAYLFFTNRHEVRKMTLDRSEYTSLIPN 425
Query: 679 LGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDG----SSRRAIIWQGLKKPKSIVLDPKK 734
L V L + + IYW+D + + I ++LD SS +I + ++ P + +D
Sbjct: 426 LRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIH 485
Query: 735 GYMYWSELGSKSIKRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPV-VEFA 792
+YW++ ++ A G ++F E + A+ +D +YW P ++
Sbjct: 486 SNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKG 545
Query: 793 FLNGTGRQTL-ADNIPMP--YALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKD 846
LNG +L +NI P L L + +YW D I +G NRK+I +D
Sbjct: 546 GLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSI-DVNGGNRKTILED 601
Score = 54.0 bits (124), Expect = 3e-06
Identities = 61/259 (23%), Positives = 104/259 (40%), Gaps = 27/259 (10%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKL----RENSSTTCYDSPQMLLVVAQRSTIS 315
C NN GCSH+C + GY C CP G +L R C D +
Sbjct: 318 CLDNNGGCSHVC--NDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGY 375
Query: 316 KISLDSP-DFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVR 374
K + P+T K + + F + E + K LD S+ + ++
Sbjct: 376 KCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHE-----------VRKMTLDRSEYTSLIP 424
Query: 375 SSGVPDSIAIDPLSRKIYWTDPVMDTINVARLD-----GSYEKVIIHTELYDPRAIALHL 429
+ ++ + S +IYW+D I +LD SY+ +I ++ P +A+
Sbjct: 425 NLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYD-TVISRDIQAPDGLAVDW 483
Query: 430 TAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDART-HK 488
++W+D + A+ G R L E + P +I +D V+ +YW D T K
Sbjct: 484 IHSNIYWTD--SVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAK 541
Query: 489 IEVCNMDGTERKELHSNDI 507
I+ ++G + L + +I
Sbjct: 542 IKKGGLNGVDIYSLVTENI 560
Score = 52.4 bits (120), Expect = 9e-06
Identities = 55/242 (22%), Positives = 92/242 (38%), Gaps = 29/242 (11%)
Query: 860 KSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRL-----NKDNITCSEPEEFLL 914
K G+N+C +NGGCSH+C D++ Y C CP ++L +D C +P+
Sbjct: 311 KECGTNECLDNNGGCSHVC----NDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQ 366
Query: 915 FAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYX 974
N G +C + + K +A V Y + H +R++ +
Sbjct: 367 LC-VNLEGGYKC---QCEEGFQLDPHTKACKA-----VGSIAYLFFTNRHEVRKMTLD-- 415
Query: 975 XXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNN---SSTGVIVRG 1031
L + +V +YW+ + I +T +D SS ++
Sbjct: 416 ----RSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISR 471
Query: 1032 DRMLPRHLAFHQTKRYLIWNDVGRGAIMRANVDGTGRVELARADNA--TALALDQSAGTV 1089
D P LA + W D G + A+ G R L R + + A+ +D G +
Sbjct: 472 DIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFM 531
Query: 1090 YW 1091
YW
Sbjct: 532 YW 533
Score = 52.0 bits (119), Expect = 1e-05
Identities = 46/231 (19%), Positives = 87/231 (37%), Gaps = 14/231 (6%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE--FLLFAQKNAVGRIMVA 927
D CS LC+ G Y+C C ++L+ C +L F ++ V ++ +
Sbjct: 360 DPDTCSQLCVNLEGG----YKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLD 415
Query: 928 NGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXX 987
E + IP L+NV A++ + ++YW D I +
Sbjct: 416 RSEYT-SLIP--NLRNVVALDTEVASNRIYWSDLSQRMICSTQLD-RAHGVSSYDTVISR 471
Query: 988 GLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRY 1047
+ P + +D + +YWT + +++ + R + PR + +
Sbjct: 472 DIQAPDGLAVDWIHSNIYWTDSVLGTVSVAD-TKGVKRKTLFRENGSKPRAIVVDPVHGF 530
Query: 1048 LIWNDVGRGA-IMRANVDGTGRVELARADN--ATALALDQSAGTVYWAVSR 1095
+ W D G A I + ++G L + + LD +G +YW S+
Sbjct: 531 MYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSK 581
Score = 51.2 bits (117), Expect = 2e-05
Identities = 31/97 (31%), Positives = 39/97 (40%), Gaps = 13/97 (13%)
Query: 1096 QCDGQQDCEDGRDEAECG--ACGGD-VRCADG----------TXXXXXXXXXXXXXXXXX 1142
+CDGQ DC++G DE C C D RC DG +
Sbjct: 88 RCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLT 147
Query: 1143 XXXDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
+F+C+ CI + CD P C DGSDE P C
Sbjct: 148 CGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRC 184
Score = 50.0 bits (114), Expect = 5e-05
Identities = 35/97 (36%), Positives = 43/97 (44%), Gaps = 19/97 (19%)
Query: 1097 CDGQQDCEDGRDEAE-------CGA----CGGDV-RC------ADGTXXXXXXXXXXXXX 1138
CDG +C+DG DE++ C + CGG V RC DG
Sbjct: 46 CDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCP 105
Query: 1139 XXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDEA 1175
D FRC +G CI+ +FVCD C DGSDEA
Sbjct: 106 PKTCSQ-DEFRCHDGKCISRQFVCDSDRDCLDGSDEA 141
Score = 46.4 bits (105), Expect = 6e-04
Identities = 16/32 (50%), Positives = 23/32 (71%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F+C +G CI+ ++VCDG +C DGSDE+ C
Sbjct: 32 FQCQDGKCISYKWVCDGSAECQDGSDESQETC 63
Score = 44.0 bits (99), Expect = 0.003
Identities = 37/119 (31%), Positives = 43/119 (36%), Gaps = 25/119 (21%)
Query: 1093 VSRQ--CDGQQDCEDGRDEAECG---------------------ACGGDVRCADGTXXXX 1129
+SRQ CD +DC DG DEA C AC D C DG+
Sbjct: 122 ISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWP 181
Query: 1130 XXXXXXXXXXXXXXXXDAFR--CDEGLCIAARFVCDGRPQCADGSDEAPAACAYGHTDQ 1186
AF C G CI + + CDG P C D SDE A A D+
Sbjct: 182 QRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDE 240
Score = 36.3 bits (80), Expect = 0.66
Identities = 27/118 (22%), Positives = 46/118 (38%), Gaps = 5/118 (4%)
Query: 945 RAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTM 1004
RAI DPV +YW D + + I + P + LD+L +
Sbjct: 520 RAIVVDPVHGFMYWTDWGTPA----KIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRL 575
Query: 1005 YWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGAIMRAN 1062
YW + SI++ + N + I+ ++ L + + + W D+ AI AN
Sbjct: 576 YWVDSKLHSISSIDV-NGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSAN 632
Score = 34.7 bits (76), Expect = 2.0
Identities = 28/100 (28%), Positives = 40/100 (40%), Gaps = 12/100 (12%)
Query: 1078 TALALDQSAGTVYWAVSRQCDGQQ-DCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXX 1136
T L +AGT AV +C+ + C+DG+ + C G C DG+
Sbjct: 11 TVALLLAAAGT---AVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVT 67
Query: 1137 XXXXXXXXXDAFRCDEGL--CIAARFVCDGRPQCADGSDE 1174
F C + CI + CDG+ C +GSDE
Sbjct: 68 CKSGD------FSCGGRVNRCIPQFWRCDGQVDCDNGSDE 101
>AC117947-1|AAX88968.1| 346|Homo sapiens unknown protein.
Length = 346
Score = 173 bits (420), Expect = 4e-42
Identities = 105/312 (33%), Positives = 165/312 (52%), Gaps = 18/312 (5%)
Query: 652 LYWSDSKTKTINRCSVNGSAVEKIV-EWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLD 710
+YW+D I+R + + E I+ LG VEG+A+DW NIYWTD IEV+RL+
Sbjct: 4 IYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLN 63
Query: 711 GSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGS-KSIKRAAMDGSSVSVFMEQ-VGRVH 768
GS R II QGL +P+SI + P+KG ++W+E G I +A +DGS V + + +
Sbjct: 64 GSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWPN 123
Query: 769 ALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTL---ADNIPMPYALALFNDSVYWGD-- 823
++IDYE +YW +E L G + + N+ M +++A+F +YW D
Sbjct: 124 GISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDM-FSVAVFGAYIYWSDRA 182
Query: 824 WNTGQIQQARKTDGSNRKSIRKDLDY-ISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTP 882
G +++ K D + ++R L + ++K+++R + G+N C DNGGC LCL
Sbjct: 183 HANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLYRG 242
Query: 883 GDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVAN-GECNDAYIPLTG- 940
RT CAC AH L +D +TC E +LL++ + + I +++ N P
Sbjct: 243 NSRRT---CAC-AHGYLAEDGVTCLRHEGYLLYSGRTILKSIHLSDETNLNSPIRPYENP 298
Query: 941 --LKNVRAIEYD 950
KNV A+ +D
Sbjct: 299 RYFKNVIALAFD 310
Score = 171 bits (416), Expect = 1e-41
Identities = 114/345 (33%), Positives = 174/345 (50%), Gaps = 18/345 (5%)
Query: 349 IYWADGLAKTISKARLDGS-DQSVVVRSSGVPDSIAIDPLSRKIYWTDPVMDTINVARLD 407
IYW D IS+A+ D + + ++ G + IA+D ++ IYWTD + I VARL+
Sbjct: 4 IYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLN 63
Query: 408 GSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWP 467
GS+ VII L PR+IA+H G +FW++W + P I +A LDGS +V+L+S + WP
Sbjct: 64 GSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQ-MPCIGKARLDGSEKVVLVSMGIAWP 122
Query: 468 NSIALDTVNNKLYWGDARTHKIEVCNMD-GTERKELHSNDIIHIFGXXXXXXXX--XXXX 524
N I++D NKLYW DART KIE +++ G R+ + S + +F
Sbjct: 123 NGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSDRA 182
Query: 525 MQKRTLDRINKNTGLDRQPVVEQM-ANMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRP 583
++ R +KN + + + N+ VK F G N CA DNGGC LC R
Sbjct: 183 HANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLYRG 242
Query: 584 DD-YICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGRLSIKNE--YNDAVIPIKD---L 637
+ C C G L D TC+ E +L+YS + I+ + + +E N + P ++
Sbjct: 243 NSRRTCACAHGY-LAEDGVTCLRHEGYLLYSGRTILKSIHLSDETNLNSPIRPYENPRYF 301
Query: 638 KEVSALALYVS-----GSKLYWSDSKTKTINRCSVNGSAVEKIVE 677
K V ALA + +++++SD+ I N + IVE
Sbjct: 302 KNVIALAFDYNQRRKGTNRIFYSDAHFGNIQLIKDNWEDRQVIVE 346
Score = 140 bits (339), Expect = 3e-32
Identities = 103/355 (29%), Positives = 166/355 (46%), Gaps = 26/355 (7%)
Query: 32 ICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAIDWYTDKLYWTDGETNKIEVI 91
I W+D I ++T+ K I++ GL GIA+DW +YWTD N IEV
Sbjct: 4 IYWTDMGFNKISRAKRDQTW---KEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVA 60
Query: 92 SIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERAGMNGDPATRKVIVRDN 151
+ +R V+ +D R+IAV PE GL+FWT+WG++P I +A ++G + + V+V
Sbjct: 61 RLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDG--SEKVVLVSMG 118
Query: 152 IFWPNGITVDYNNSLIYWVDAKLQFVDVIDF-NGEKRKRVVKGGLVYPFALTFSNDKLYW 210
I WPNGI++DY + +YW DA+ ++ ID G R+ V+ G V F++ +YW
Sbjct: 119 IAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYIYW 178
Query: 211 TD--WQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESRQIISAEDYPCKKNNAGCS 268
+D N S+ + + + ++K ++ C ++N GC
Sbjct: 179 SDRAHANGSVRR---GHKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGGCK 235
Query: 269 HLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLL-----VVAQRSTISKISLDSPD 323
LCL + CAC G L E+ TC LL ++ + +L+SP
Sbjct: 236 QLCLYRGN-SRRTCACAHGY-LAED-GVTCLRHEGYLLYSGRTILKSIHLSDETNLNSP- 291
Query: 324 FTPYTLPLKDLKRTLTVDFD-----PKTEYIYWADGLAKTISKARLDGSDQSVVV 373
PY P + K + + FD T I+++D I + + D+ V+V
Sbjct: 292 IRPYENP-RYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNIQLIKDNWEDRQVIV 345
Score = 62.9 bits (146), Expect = 7e-09
Identities = 42/155 (27%), Positives = 73/155 (47%), Gaps = 6/155 (3%)
Query: 76 DKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEIPKIERA 135
D +YWTD NKI Q +++ + + + IAV G ++WTD G IE A
Sbjct: 2 DTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHG-FNLIEVA 60
Query: 136 GMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVD-AKLQFVDVIDFNGEKRKRVVKGG 194
+NG + R VI+ + P I V L++W + ++ + +G ++ +V G
Sbjct: 61 RLNG--SFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMG 118
Query: 195 LVYP--FALTFSNDKLYWTDWQNWSIYTWDIAANG 227
+ +P ++ + +KLYW D + I D+ G
Sbjct: 119 IAWPNGISIDYEENKLYWCDARTDKIERIDLETGG 153
Score = 62.5 bits (145), Expect = 9e-09
Identities = 43/146 (29%), Positives = 68/146 (46%), Gaps = 8/146 (5%)
Query: 9 RITTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTG 68
R I++ L+Q ++ H K L+ W++ + C+ EK +VS G+ P G
Sbjct: 67 RYVIISQGLDQPRSIAVHPEKGLLFWTEWGQ--MPCIGKARLDGSEKVVLVSMGIAWPNG 124
Query: 69 IAIDWYTDKLYWTDGETNKIEVISIVQ--KYRKVLFWSEVDLARAIAVVPEDGLMFWTDW 126
I+ID+ +KLYW D T+KIE I + VL S VD+ +V ++W+D
Sbjct: 125 ISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDM---FSVAVFGAYIYWSDR 181
Query: 127 GEIPKIERAGMNGDPATRKVIVRDNI 152
R G D AT + +R +
Sbjct: 182 AHANGSVRRGHKND-ATETITMRTGL 206
Score = 44.4 bits (100), Expect = 0.002
Identities = 31/111 (27%), Positives = 50/111 (45%), Gaps = 4/111 (3%)
Query: 988 GLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRY 1047
GL R + +D + +YWT + I + N S VI+ PR +A H K
Sbjct: 31 GLGRVEGIAVDWIAGNIYWTDHGFNLIEVARL-NGSFRYVIISQGLDQPRSIAVHPEKGL 89
Query: 1048 LIWNDVGR-GAIMRANVDGTGRVELARADNA--TALALDQSAGTVYWAVSR 1095
L W + G+ I +A +DG+ +V L A +++D +YW +R
Sbjct: 90 LFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDAR 140
>AB209409-1|BAD92646.1| 870|Homo sapiens low density lipoprotein
receptor precursor variant protein.
Length = 870
Score = 173 bits (420), Expect = 4e-42
Identities = 105/376 (27%), Positives = 188/376 (50%), Gaps = 20/376 (5%)
Query: 571 DNGGCSHLCFNRPDDYICGCPLGLELTADKKTC--VEPEAFLVYSRKNIIGRLSIKNEYN 628
D CS LC N Y C C G +L K C V A+L ++ ++ + ++++
Sbjct: 372 DPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEY 431
Query: 629 DAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNG----SAVEKIVEW-LGLVE 683
++IP +L+ V AL V+ +++YWSD + I ++ S+ + ++ + +
Sbjct: 432 TSLIP--NLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPD 489
Query: 684 GLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELG 743
GLA+DW NIYWTD+ + V+ G R+ + + KP++IV+DP G+MYW++ G
Sbjct: 490 GLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWG 549
Query: 744 SKS-IKRAAMDGSSV-SVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQT 801
+ + IK+ ++G + S+ E + + + +D +YW + +NG R+T
Sbjct: 550 TPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKT 609
Query: 802 LADN---IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHR 858
+ ++ + P++LA+F D V+W D I A + GS+ + ++L D+ L+H
Sbjct: 610 ILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHN 669
Query: 859 -AKSMGSNQC---GVDNGGCSHLCLPTP--GDVRTDYRCACPAHYRLNKDNITCSEPEEF 912
+ G N C + NGGC +LCLP P + CACP L +D +C E
Sbjct: 670 LTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEA 729
Query: 913 LLFAQKNAVGRIMVAN 928
+ Q+ + R+ V++
Sbjct: 730 AVATQETSTVRLKVSS 745
Score = 172 bits (419), Expect = 6e-42
Identities = 98/314 (31%), Positives = 155/314 (49%), Gaps = 16/314 (5%)
Query: 11 TTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFK-IVSEGLVTPTGI 69
T++ +L A+D N I WSD +I + + + ++S + P G+
Sbjct: 432 TSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGL 491
Query: 70 AIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEI 129
A+DW +YWTD + V RK LF RAI V P G M+WTDWG
Sbjct: 492 AVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTP 551
Query: 130 PKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKR 189
KI++ G+NG +V +NI WPNGIT+D + +YWVD+KL + ID NG RK
Sbjct: 552 AKIKKGGLNG--VDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKT 609
Query: 190 VVKG--GLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYD 247
+++ L +PF+L DK++WTD N +I++ + G + L ++ P D+ ++
Sbjct: 610 ILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSAN-RLTGSDVNLLAENLLSPEDMVLFH 668
Query: 248 ESRQIISAEDYPCKK---NNAGCSHLCL----LSPDPPGYNCACPTGVKLRENSSTTCYD 300
Q C++ +N GC +LCL ++P P + CACP G+ L + +C
Sbjct: 669 NLTQPRGVN--WCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARD-MRSCLT 725
Query: 301 SPQMLLVVAQRSTI 314
+ + + ST+
Sbjct: 726 EAEAAVATQETSTV 739
Score = 164 bits (399), Expect = 1e-39
Identities = 104/376 (27%), Positives = 171/376 (45%), Gaps = 23/376 (6%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDSPDFTP 326
CS LC+ GY C C G +L ++ L R + K++LD +
Sbjct: 376 CSQLCVNLEG--GYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSE--- 430
Query: 327 YTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLD-----GSDQSVVVRSSGVPDS 381
YT + +L+ + +D + + IYW+D + I +LD S +V+ R PD
Sbjct: 431 YTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDG 490
Query: 382 IAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNE 441
+A+D + IYWTD V+ T++VA G K + PRAI + G+M+W+DW
Sbjct: 491 LAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWG- 549
Query: 442 KKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKE 501
KI++ L+G L++E + WPN I LD ++ +LYW D++ H I +++G RK
Sbjct: 550 TPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKT 609
Query: 502 LHSND--IIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAF-R 558
+ ++ + H F + + N+ TG D + E + + + F
Sbjct: 610 ILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHN 669
Query: 559 LGAPLGWNPCAD---DNGGCSHLCFNRPD------DYICGCPLGLELTADKKTCVEPEAF 609
L P G N C NGGC +LC P + C CP G+ L D ++C+
Sbjct: 670 LTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEA 729
Query: 610 LVYSRKNIIGRLSIKN 625
V +++ RL + +
Sbjct: 730 AVATQETSTVRLKVSS 745
Score = 81.4 bits (192), Expect = 2e-14
Identities = 75/297 (25%), Positives = 128/297 (43%), Gaps = 23/297 (7%)
Query: 564 GWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKK-----TCVEPEAFLVYSRKNII 618
G N C D+NGGCSH+C + Y C CP G +L A ++ C +P+ N+
Sbjct: 326 GTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLC-VNLE 384
Query: 619 GRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEW 678
G + E + P K A+ GS Y + + + +++ S ++
Sbjct: 385 GGYKCQCEEGFQLDP--HTKACKAV-----GSIAYLFFTNRHEVRKMTLDRSEYTSLIPN 437
Query: 679 LGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDG----SSRRAIIWQGLKKPKSIVLDPKK 734
L V L + + IYW+D + + I ++LD SS +I + ++ P + +D
Sbjct: 438 LRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIH 497
Query: 735 GYMYWSELGSKSIKRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPV-VEFA 792
+YW++ ++ A G ++F E + A+ +D +YW P ++
Sbjct: 498 SNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKG 557
Query: 793 FLNGTGRQTL-ADNIPMP--YALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKD 846
LNG +L +NI P L L + +YW D I +G NRK+I +D
Sbjct: 558 GLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSI-DVNGGNRKTILED 613
Score = 54.0 bits (124), Expect = 3e-06
Identities = 61/259 (23%), Positives = 104/259 (40%), Gaps = 27/259 (10%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKL----RENSSTTCYDSPQMLLVVAQRSTIS 315
C NN GCSH+C + GY C CP G +L R C D +
Sbjct: 330 CLDNNGGCSHVC--NDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGY 387
Query: 316 KISLDSP-DFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVR 374
K + P+T K + + F + E + K LD S+ + ++
Sbjct: 388 KCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHE-----------VRKMTLDRSEYTSLIP 436
Query: 375 SSGVPDSIAIDPLSRKIYWTDPVMDTINVARLD-----GSYEKVIIHTELYDPRAIALHL 429
+ ++ + S +IYW+D I +LD SY+ +I ++ P +A+
Sbjct: 437 NLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYD-TVISRDIQAPDGLAVDW 495
Query: 430 TAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDART-HK 488
++W+D + A+ G R L E + P +I +D V+ +YW D T K
Sbjct: 496 IHSNIYWTD--SVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAK 553
Query: 489 IEVCNMDGTERKELHSNDI 507
I+ ++G + L + +I
Sbjct: 554 IKKGGLNGVDIYSLVTENI 572
Score = 52.4 bits (120), Expect = 9e-06
Identities = 55/242 (22%), Positives = 92/242 (38%), Gaps = 29/242 (11%)
Query: 860 KSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRL-----NKDNITCSEPEEFLL 914
K G+N+C +NGGCSH+C D++ Y C CP ++L +D C +P+
Sbjct: 323 KECGTNECLDNNGGCSHVC----NDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQ 378
Query: 915 FAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYX 974
N G +C + + K +A V Y + H +R++ +
Sbjct: 379 LC-VNLEGGYKC---QCEEGFQLDPHTKACKA-----VGSIAYLFFTNRHEVRKMTLD-- 427
Query: 975 XXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNN---SSTGVIVRG 1031
L + +V +YW+ + I +T +D SS ++
Sbjct: 428 ----RSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISR 483
Query: 1032 DRMLPRHLAFHQTKRYLIWNDVGRGAIMRANVDGTGRVELARADNA--TALALDQSAGTV 1089
D P LA + W D G + A+ G R L R + + A+ +D G +
Sbjct: 484 DIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFM 543
Query: 1090 YW 1091
YW
Sbjct: 544 YW 545
Score = 52.0 bits (119), Expect = 1e-05
Identities = 46/231 (19%), Positives = 87/231 (37%), Gaps = 14/231 (6%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE--FLLFAQKNAVGRIMVA 927
D CS LC+ G Y+C C ++L+ C +L F ++ V ++ +
Sbjct: 372 DPDTCSQLCVNLEGG----YKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLD 427
Query: 928 NGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXX 987
E + IP L+NV A++ + ++YW D I +
Sbjct: 428 RSEYT-SLIP--NLRNVVALDTEVASNRIYWSDLSQRMICSTQLD-RAHGVSSYDTVISR 483
Query: 988 GLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRY 1047
+ P + +D + +YWT + +++ + R + PR + +
Sbjct: 484 DIQAPDGLAVDWIHSNIYWTDSVLGTVSVAD-TKGVKRKTLFRENGSKPRAIVVDPVHGF 542
Query: 1048 LIWNDVGRGA-IMRANVDGTGRVELARADN--ATALALDQSAGTVYWAVSR 1095
+ W D G A I + ++G L + + LD +G +YW S+
Sbjct: 543 MYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSK 593
Score = 51.2 bits (117), Expect = 2e-05
Identities = 31/97 (31%), Positives = 39/97 (40%), Gaps = 13/97 (13%)
Query: 1096 QCDGQQDCEDGRDEAECG--ACGGD-VRCADG----------TXXXXXXXXXXXXXXXXX 1142
+CDGQ DC++G DE C C D RC DG +
Sbjct: 100 RCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLT 159
Query: 1143 XXXDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
+F+C+ CI + CD P C DGSDE P C
Sbjct: 160 CGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRC 196
Score = 50.0 bits (114), Expect = 5e-05
Identities = 35/97 (36%), Positives = 43/97 (44%), Gaps = 19/97 (19%)
Query: 1097 CDGQQDCEDGRDEAE-------CGA----CGGDV-RC------ADGTXXXXXXXXXXXXX 1138
CDG +C+DG DE++ C + CGG V RC DG
Sbjct: 58 CDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCP 117
Query: 1139 XXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDEA 1175
D FRC +G CI+ +FVCD C DGSDEA
Sbjct: 118 PKTCSQ-DEFRCHDGKCISRQFVCDSDRDCLDGSDEA 153
Score = 46.4 bits (105), Expect = 6e-04
Identities = 16/32 (50%), Positives = 23/32 (71%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F+C +G CI+ ++VCDG +C DGSDE+ C
Sbjct: 44 FQCQDGKCISYKWVCDGSAECQDGSDESQETC 75
Score = 44.0 bits (99), Expect = 0.003
Identities = 37/119 (31%), Positives = 43/119 (36%), Gaps = 25/119 (21%)
Query: 1093 VSRQ--CDGQQDCEDGRDEAECG---------------------ACGGDVRCADGTXXXX 1129
+SRQ CD +DC DG DEA C AC D C DG+
Sbjct: 134 ISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWP 193
Query: 1130 XXXXXXXXXXXXXXXXDAFR--CDEGLCIAARFVCDGRPQCADGSDEAPAACAYGHTDQ 1186
AF C G CI + + CDG P C D SDE A A D+
Sbjct: 194 QRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDE 252
Score = 36.3 bits (80), Expect = 0.66
Identities = 27/118 (22%), Positives = 46/118 (38%), Gaps = 5/118 (4%)
Query: 945 RAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTM 1004
RAI DPV +YW D + + I + P + LD+L +
Sbjct: 532 RAIVVDPVHGFMYWTDWGTPA----KIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRL 587
Query: 1005 YWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGAIMRAN 1062
YW + SI++ + N + I+ ++ L + + + W D+ AI AN
Sbjct: 588 YWVDSKLHSISSIDV-NGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSAN 644
Score = 34.7 bits (76), Expect = 2.0
Identities = 28/100 (28%), Positives = 40/100 (40%), Gaps = 12/100 (12%)
Query: 1078 TALALDQSAGTVYWAVSRQCDGQQ-DCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXX 1136
T L +AGT AV +C+ + C+DG+ + C G C DG+
Sbjct: 23 TVALLLAAAGT---AVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVT 79
Query: 1137 XXXXXXXXXDAFRCDEGL--CIAARFVCDGRPQCADGSDE 1174
F C + CI + CDG+ C +GSDE
Sbjct: 80 CKSGD------FSCGGRVNRCIPQFWRCDGQVDCDNGSDE 113
>AF217403-1|AAF24515.1| 837|Homo sapiens low density lipoprotein
receptor protein.
Length = 837
Score = 172 bits (419), Expect = 6e-42
Identities = 98/314 (31%), Positives = 155/314 (49%), Gaps = 16/314 (5%)
Query: 11 TTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFK-IVSEGLVTPTGI 69
T++ +L A+D N I WSD +I + + + ++S + P G+
Sbjct: 397 TSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGL 456
Query: 70 AIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWGEI 129
A+DW +YWTD + V RK LF RAI V P G M+WTDWG
Sbjct: 457 AVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTP 516
Query: 130 PKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKR 189
KI++ G+NG +V +NI WPNGIT+D + +YWVD+KL + ID NG RK
Sbjct: 517 AKIKKGGLNG--VDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKT 574
Query: 190 VVKG--GLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYD 247
+++ L +PF+L DK++WTD N +I++ + G + L ++ P D+ ++
Sbjct: 575 ILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSAN-RLTGSDVNLLAENLLSPEDMVLFH 633
Query: 248 ESRQIISAEDYPCKK---NNAGCSHLCL----LSPDPPGYNCACPTGVKLRENSSTTCYD 300
Q C++ +N GC +LCL ++P P + CACP G+ L + +C
Sbjct: 634 NLTQPRGVN--WCERTTLSNGGCQYLCLPASQINPHSPKFTCACPDGMLLARD-MRSCLT 690
Query: 301 SPQMLLVVAQRSTI 314
+ + + ST+
Sbjct: 691 EAEAAVATQETSTV 704
Score = 169 bits (412), Expect = 4e-41
Identities = 104/376 (27%), Positives = 187/376 (49%), Gaps = 20/376 (5%)
Query: 571 DNGGCSHLCFNRPDDYICGCPLGLELTADKKTC--VEPEAFLVYSRKNIIGRLSIKNEYN 628
D CS LC N Y C C G +L K C V A+L ++ ++ + ++++
Sbjct: 337 DPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEY 396
Query: 629 DAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNG----SAVEKIVEW-LGLVE 683
++IP +L+ V AL V+ +++YWSD + I ++ S+ + ++ + +
Sbjct: 397 TSLIP--NLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPD 454
Query: 684 GLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELG 743
GLA+DW NIYWTD+ + V+ G R+ + + KP++IV+DP G+MYW++ G
Sbjct: 455 GLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWG 514
Query: 744 SKS-IKRAAMDGSSV-SVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQT 801
+ + IK+ ++G + S+ E + + + +D +YW + +NG R+T
Sbjct: 515 TPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKT 574
Query: 802 LADN---IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHR 858
+ ++ + P++LA+F D V+W D I A + GS+ + ++L D+ L+H
Sbjct: 575 ILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHN 634
Query: 859 -AKSMGSNQC---GVDNGGCSHLCLPTP--GDVRTDYRCACPAHYRLNKDNITCSEPEEF 912
+ G N C + NGGC +LCLP + CACP L +D +C E
Sbjct: 635 LTQPRGVNWCERTTLSNGGCQYLCLPASQINPHSPKFTCACPDGMLLARDMRSCLTEAEA 694
Query: 913 LLFAQKNAVGRIMVAN 928
+ Q+ + R+ V++
Sbjct: 695 AVATQETSTVRLKVSS 710
Score = 161 bits (391), Expect = 1e-38
Identities = 103/376 (27%), Positives = 170/376 (45%), Gaps = 23/376 (6%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDSPDFTP 326
CS LC+ GY C C G +L ++ L R + K++LD +
Sbjct: 341 CSQLCVNLEG--GYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSE--- 395
Query: 327 YTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLD-----GSDQSVVVRSSGVPDS 381
YT + +L+ + +D + + IYW+D + I +LD S +V+ R PD
Sbjct: 396 YTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDG 455
Query: 382 IAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNE 441
+A+D + IYWTD V+ T++VA G K + PRAI + G+M+W+DW
Sbjct: 456 LAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWG- 514
Query: 442 KKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKE 501
KI++ L+G L++E + WPN I LD ++ +LYW D++ H I +++G RK
Sbjct: 515 TPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKT 574
Query: 502 LHSND--IIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAF-R 558
+ ++ + H F + + N+ TG D + E + + + F
Sbjct: 575 ILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHN 634
Query: 559 LGAPLGWNPCAD---DNGGCSHLCF------NRPDDYICGCPLGLELTADKKTCVEPEAF 609
L P G N C NGGC +LC + C CP G+ L D ++C+
Sbjct: 635 LTQPRGVNWCERTTLSNGGCQYLCLPASQINPHSPKFTCACPDGMLLARDMRSCLTEAEA 694
Query: 610 LVYSRKNIIGRLSIKN 625
V +++ RL + +
Sbjct: 695 AVATQETSTVRLKVSS 710
Score = 81.4 bits (192), Expect = 2e-14
Identities = 75/297 (25%), Positives = 128/297 (43%), Gaps = 23/297 (7%)
Query: 564 GWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKK-----TCVEPEAFLVYSRKNII 618
G N C D+NGGCSH+C + Y C CP G +L A ++ C +P+ N+
Sbjct: 291 GTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLC-VNLE 349
Query: 619 GRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEW 678
G + E + P K A+ GS Y + + + +++ S ++
Sbjct: 350 GGYKCQCEEGFQLDP--HTKACKAV-----GSIAYLFFTNRHEVRKMTLDRSEYTSLIPN 402
Query: 679 LGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDG----SSRRAIIWQGLKKPKSIVLDPKK 734
L V L + + IYW+D + + I ++LD SS +I + ++ P + +D
Sbjct: 403 LRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIH 462
Query: 735 GYMYWSELGSKSIKRAAMDG-SSVSVFMEQVGRVHALAIDYERRAIYWAALDPPV-VEFA 792
+YW++ ++ A G ++F E + A+ +D +YW P ++
Sbjct: 463 SNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKG 522
Query: 793 FLNGTGRQTL-ADNIPMP--YALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKD 846
LNG +L +NI P L L + +YW D I +G NRK+I +D
Sbjct: 523 GLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSI-DVNGGNRKTILED 578
Score = 54.0 bits (124), Expect = 3e-06
Identities = 61/259 (23%), Positives = 104/259 (40%), Gaps = 27/259 (10%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKL----RENSSTTCYDSPQMLLVVAQRSTIS 315
C NN GCSH+C + GY C CP G +L R C D +
Sbjct: 295 CLDNNGGCSHVC--NDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGY 352
Query: 316 KISLDSP-DFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVR 374
K + P+T K + + F + E + K LD S+ + ++
Sbjct: 353 KCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHE-----------VRKMTLDRSEYTSLIP 401
Query: 375 SSGVPDSIAIDPLSRKIYWTDPVMDTINVARLD-----GSYEKVIIHTELYDPRAIALHL 429
+ ++ + S +IYW+D I +LD SY+ +I ++ P +A+
Sbjct: 402 NLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYD-TVISRDIQAPDGLAVDW 460
Query: 430 TAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDART-HK 488
++W+D + A+ G R L E + P +I +D V+ +YW D T K
Sbjct: 461 IHSNIYWTD--SVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAK 518
Query: 489 IEVCNMDGTERKELHSNDI 507
I+ ++G + L + +I
Sbjct: 519 IKKGGLNGVDIYSLVTENI 537
Score = 52.4 bits (120), Expect = 9e-06
Identities = 55/242 (22%), Positives = 92/242 (38%), Gaps = 29/242 (11%)
Query: 860 KSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRL-----NKDNITCSEPEEFLL 914
K G+N+C +NGGCSH+C D++ Y C CP ++L +D C +P+
Sbjct: 288 KECGTNECLDNNGGCSHVC----NDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQ 343
Query: 915 FAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYX 974
N G +C + + K +A V Y + H +R++ +
Sbjct: 344 LC-VNLEGGYKC---QCEEGFQLDPHTKACKA-----VGSIAYLFFTNRHEVRKMTLD-- 392
Query: 975 XXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNN---SSTGVIVRG 1031
L + +V +YW+ + I +T +D SS ++
Sbjct: 393 ----RSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISR 448
Query: 1032 DRMLPRHLAFHQTKRYLIWNDVGRGAIMRANVDGTGRVELARADNA--TALALDQSAGTV 1089
D P LA + W D G + A+ G R L R + + A+ +D G +
Sbjct: 449 DIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFM 508
Query: 1090 YW 1091
YW
Sbjct: 509 YW 510
Score = 52.0 bits (119), Expect = 1e-05
Identities = 46/231 (19%), Positives = 87/231 (37%), Gaps = 14/231 (6%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE--FLLFAQKNAVGRIMVA 927
D CS LC+ G Y+C C ++L+ C +L F ++ V ++ +
Sbjct: 337 DPDTCSQLCVNLEGG----YKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLD 392
Query: 928 NGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXX 987
E + IP L+NV A++ + ++YW D I +
Sbjct: 393 RSEYT-SLIP--NLRNVVALDTEVASNRIYWSDLSQRMICSTQLD-RAHGVSSYDTVISR 448
Query: 988 GLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRY 1047
+ P + +D + +YWT + +++ + R + PR + +
Sbjct: 449 DIQAPDGLAVDWIHSNIYWTDSVLGTVSVAD-TKGVKRKTLFRENGSKPRAIVVDPVHGF 507
Query: 1048 LIWNDVGRGA-IMRANVDGTGRVELARADN--ATALALDQSAGTVYWAVSR 1095
+ W D G A I + ++G L + + LD +G +YW S+
Sbjct: 508 MYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSK 558
Score = 51.2 bits (117), Expect = 2e-05
Identities = 31/97 (31%), Positives = 39/97 (40%), Gaps = 13/97 (13%)
Query: 1096 QCDGQQDCEDGRDEAECG--ACGGD-VRCADG----------TXXXXXXXXXXXXXXXXX 1142
+CDGQ DC++G DE C C D RC DG +
Sbjct: 65 RCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLT 124
Query: 1143 XXXDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
+F+C+ CI + CD P C DGSDE P C
Sbjct: 125 CGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRC 161
Score = 50.0 bits (114), Expect = 5e-05
Identities = 35/97 (36%), Positives = 43/97 (44%), Gaps = 19/97 (19%)
Query: 1097 CDGQQDCEDGRDEAE-------CGA----CGGDV-RC------ADGTXXXXXXXXXXXXX 1138
CDG +C+DG DE++ C + CGG V RC DG
Sbjct: 23 CDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCP 82
Query: 1139 XXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDEA 1175
D FRC +G CI+ +FVCD C DGSDEA
Sbjct: 83 PKTCSQ-DEFRCHDGKCISRQFVCDSDRDCLDGSDEA 118
Score = 46.4 bits (105), Expect = 6e-04
Identities = 16/32 (50%), Positives = 23/32 (71%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F+C +G CI+ ++VCDG +C DGSDE+ C
Sbjct: 9 FQCQDGKCISYKWVCDGSAECQDGSDESQETC 40
Score = 44.0 bits (99), Expect = 0.003
Identities = 37/119 (31%), Positives = 43/119 (36%), Gaps = 25/119 (21%)
Query: 1093 VSRQ--CDGQQDCEDGRDEAECG---------------------ACGGDVRCADGTXXXX 1129
+SRQ CD +DC DG DEA C AC D C DG+
Sbjct: 99 ISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWP 158
Query: 1130 XXXXXXXXXXXXXXXXDAFR--CDEGLCIAARFVCDGRPQCADGSDEAPAACAYGHTDQ 1186
AF C G CI + + CDG P C D SDE A A D+
Sbjct: 159 QRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDE 217
Score = 36.3 bits (80), Expect = 0.66
Identities = 27/118 (22%), Positives = 46/118 (38%), Gaps = 5/118 (4%)
Query: 945 RAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTM 1004
RAI DPV +YW D + + I + P + LD+L +
Sbjct: 497 RAIVVDPVHGFMYWTDWGTPA----KIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRL 552
Query: 1005 YWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGAIMRAN 1062
YW + SI++ + N + I+ ++ L + + + W D+ AI AN
Sbjct: 553 YWVDSKLHSISSIDV-NGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSAN 609
>AC008178-1|AAY24266.1| 773|Homo sapiens unknown protein.
Length = 773
Score = 167 bits (407), Expect = 2e-40
Identities = 100/345 (28%), Positives = 170/345 (49%), Gaps = 14/345 (4%)
Query: 340 VDFDPKTEYIYWADGLAKTISKARLDGSD-QSVVVRSSGVPDSIAIDPLSRKIYWTDPVM 398
V F + ++W D + + ++G + Q V+ S P+++A+D ++ KIY + +
Sbjct: 429 VAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKV 488
Query: 399 DTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEK--KPKIERANLDGSGR 456
+ I++ LDGSY +I L PR IA+ T G++F+SDW +PK+ERA +DGS R
Sbjct: 489 NRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNR 548
Query: 457 VLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKE-LHSNDII-HIFGXX 514
L+ KL WP + LD ++ ++YW D+R IE DG +RK +H +I H FG
Sbjct: 549 KDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVS 608
Query: 515 XXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFR-LGAPLGWNPCADDNG 573
K + + NK T + Q + GV + L P NPC D+NG
Sbjct: 609 LFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDNNG 668
Query: 574 GCSHLCF--NRPDD----YICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGRLSIK-NE 626
GC +C +R D+ + C C G +L D++ C+ + FL++S + I + +
Sbjct: 669 GCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQNFLIFSSQVAIRGIPFTLST 728
Query: 627 YNDAVIPIK-DLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGS 670
D ++P+ + + S +++SD I + ++G+
Sbjct: 729 QEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGT 773
Score = 165 bits (401), Expect = 8e-40
Identities = 101/373 (27%), Positives = 184/373 (49%), Gaps = 22/373 (5%)
Query: 6 RLTRITTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVT 65
R RI +++ V FHY + W+D + ++ N E + E T
Sbjct: 412 RSFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVE---T 468
Query: 66 PTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTD 125
P +A+DW +K+Y + + N+I+++++ YR L + R IAV P G +F++D
Sbjct: 469 PENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSD 528
Query: 126 WGEI---PKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDF 182
W + PK+ERA M+G + RK +V+ + WP G+T+D + +YWVD++ +++ + +
Sbjct: 529 WESLSGEPKLERAFMDG--SNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTY 586
Query: 183 NGEKRKRVVKGG--LVYPFALTFSNDKLYWTDWQNWSIYTWD-IAANGPKIKELIKSHPV 239
+G +RK VV GG + +PF ++ ++++TDW ++ + P++ ++
Sbjct: 587 DGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQV--YYQASLR 644
Query: 240 PADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLS----PDPPGYNCACPTGVKLRENSS 295
P + VY RQ + PCK NN GC +C+LS D G+ C C G +L +
Sbjct: 645 PYGVTVYHSLRQPYATN--PCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQL-DTDE 701
Query: 296 TTCYDSPQMLLVVAQRSTISKISLDSPDFTPYTLPLK-DLKRTLTVDFDPKTEYIYWADG 354
C + Q L+ + + I I +P+ + + +DFD + I+++D
Sbjct: 702 RHCI-AVQNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDM 760
Query: 355 LAKTISKARLDGS 367
I K ++DG+
Sbjct: 761 SKHMIFKQKIDGT 773
Score = 146 bits (353), Expect = 6e-34
Identities = 102/413 (24%), Positives = 189/413 (45%), Gaps = 22/413 (5%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTCVEP---EAFLVYS--RKNIIGRLSIKNEY 627
G C C +RP ++C C G L + EA +++S R +IG I
Sbjct: 356 GICDQKCESRPGRHLCHCEEGYILERGQYCKANDSFGEASIIFSNGRDLLIG--DIHGRS 413
Query: 628 NDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEW-LGLVEGLA 686
++ ++ +A + +++W+D+ + +NG +++++ + E LA
Sbjct: 414 FRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLA 473
Query: 687 IDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMY---WSEL- 742
+DW IY +T RI++ LDGS R +I + L P+ I +DP GY++ W L
Sbjct: 474 VDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLS 533
Query: 743 GSKSIKRAAMDGSS-VSVFMEQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQT 801
G ++RA MDGS+ + ++G + +D + +YW +E +G R+T
Sbjct: 534 GEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKT 593
Query: 802 LADN---IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHR 858
+ IP P+ ++LF V++ DW + +A K +N + + + +YH
Sbjct: 594 VVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHS 653
Query: 859 AKS-MGSNQCGVDNGGCSHLCL---PTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL 914
+ +N C +NGGC +C+ T D +RC C ++L+ D C + FL+
Sbjct: 654 LRQPYATNPCKDNNGGCEQVCVLSHRTDND-GLGFRCKCTFGFQLDTDERHCIAVQNFLI 712
Query: 915 FAQKNAVGRIMVANGECNDAYIPLTGLKN-VRAIEYDPVEKQLYWMDDDSHSI 966
F+ + A+ I D +P++G + I++D + +++ D H I
Sbjct: 713 FSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMI 765
Score = 39.5 bits (88), Expect = 0.071
Identities = 29/97 (29%), Positives = 36/97 (37%), Gaps = 14/97 (14%)
Query: 1096 QCDGQQDCEDGRDEAECG--ACGGDVRCADGTXXXXXXX---------XXXXXXXXXXXX 1144
+CD +DC DG DE +C C + C +G
Sbjct: 126 RCDHVRDCPDGADENDCQYPTCE-QLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEICL 184
Query: 1145 XDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAACAY 1181
+ F C G CI +VCD C DGSDE AC Y
Sbjct: 185 HNEFSCGNGECIPRAYVCDHDNDCQDGSDE--HACNY 219
Score = 37.5 bits (83), Expect = 0.29
Identities = 26/93 (27%), Positives = 32/93 (34%), Gaps = 12/93 (12%)
Query: 1094 SRQCDGQQDCEDGRDEAECGA-C-GGDVRCADGTXXXXXXXXXXXXXXXXXXXXDA---- 1147
S++CD + DC D DE C C + C +G A
Sbjct: 161 SQKCDWKVDCRDSSDEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYP 220
Query: 1148 ------FRCDEGLCIAARFVCDGRPQCADGSDE 1174
F C G CI +VCDG C D DE
Sbjct: 221 TCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDE 253
Score = 37.1 bits (82), Expect = 0.38
Identities = 17/39 (43%), Positives = 21/39 (53%), Gaps = 3/39 (7%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDE---APAACAYGH 1183
FRC G CI A + CDG C+D +DE A C G+
Sbjct: 33 FRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGY 71
Score = 34.7 bits (76), Expect = 2.0
Identities = 25/76 (32%), Positives = 29/76 (38%), Gaps = 4/76 (5%)
Query: 1101 QDCEDGRDEAECGAC-GGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCD-EGLCIAA 1158
Q+C+ G C D RC DGT F+C EG CI
Sbjct: 26 QECDSAHFRCGSGHCIPADWRC-DGTKDCSDDADEIGCAVVTCQQG-YFKCQSEGQCIPN 83
Query: 1159 RFVCDGRPQCADGSDE 1174
+VCD C DGSDE
Sbjct: 84 SWVCDQDQDCDDGSDE 99
>Y08110-1|CAA69325.1| 2214|Homo sapiens mosaic protein LR11 protein.
Length = 2214
Score = 158 bits (384), Expect = 1e-37
Identities = 100/319 (31%), Positives = 164/319 (51%), Gaps = 17/319 (5%)
Query: 605 EPEAFLVYSRKNIIGRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINR 664
E F++Y+ + I R + + + +P+ L+ AL + LYWSD I R
Sbjct: 756 EENEFILYAVRKSIYRYDLASGATEQ-LPLTGLRAAVALDFDYEHNCLYWSDLALDVIQR 814
Query: 665 CSVNGSAVEKIVEWLGL--VEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQG- 721
+NGS ++++ GL VE LA + Q +YW D ++IEV+ DG R I+
Sbjct: 815 LCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSV 874
Query: 722 LKKPKSIVLDPKKGYMYWSELGS--KSIKRAAMDGSSV-SVFMEQVGRVHALAIDYERRA 778
L +P+++VL P++G M+W++ G I R+ MDGS+ + E V + +++D +
Sbjct: 875 LDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVDDQW-- 932
Query: 779 IYWAALDPPVVEFAFLNGTGRQTLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGS 838
IYW +E +G R + DN+P PYA+A+F + +YW DW+ I +A K GS
Sbjct: 933 IYWTDAYLECIERITFSGQQRSVILDNLPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGS 992
Query: 839 NRKSIRKDLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYR 898
+ + L + D+K++++ K+ GSN C V CS LCLP + R+ C CP
Sbjct: 993 QMEILANQLTGLMDMKIFYKGKNTGSNAC-VPR-PCSLLCLPKANNSRS---CRCPEDVS 1047
Query: 899 ---LNKDNITCSEPEEFLL 914
L ++ C P+ + L
Sbjct: 1048 SSVLPSGDLMCDCPQGYQL 1066
Score = 149 bits (361), Expect = 6e-35
Identities = 92/274 (33%), Positives = 148/274 (54%), Gaps = 16/274 (5%)
Query: 17 LEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAIDWYTD 76
L A+DF Y N + WSD ++IQ + N + TG++ I++ GL T +A + +
Sbjct: 787 LRAAVALDFDYEHNCLYWSDLALDVIQRLCLNGS-TGQEV-IINSGLETVEALAFEPLSQ 844
Query: 77 KLYWTDGETNKIEVISIVQKYRKVLFWSEV-DLARAIAVVPEDGLMFWTDWGEI-PKIER 134
LYW D KIEV + +R + S V D RA+ +VP++G+MFWTDWG++ P I R
Sbjct: 845 LLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYR 904
Query: 135 AGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVKGG 194
+ M+G A +V +++ WPNGI+VD + IYW DA L+ ++ I F+G++R V+
Sbjct: 905 SNMDGSAAYH--LVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQQRS-VILDN 959
Query: 195 LVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESRQIIS 254
L +P+A+ +++YW DW SI+ +G +++ L D+K++ + + S
Sbjct: 960 LPHPYAIAVFKNEIYWDDWSQLSIFRAS-KYSGSQMEILANQLTGLMDMKIFYKGKNTGS 1018
Query: 255 AEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGV 288
P CS LCL + +C CP V
Sbjct: 1019 NACVP-----RPCSLLCLPKAN-NSRSCRCPEDV 1046
Score = 147 bits (356), Expect = 2e-34
Identities = 85/267 (31%), Positives = 135/267 (50%), Gaps = 9/267 (3%)
Query: 329 LPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGVP--DSIAIDP 386
LPL L+ + +DFD + +YW+D I + L+GS V+ +SG+ +++A +P
Sbjct: 782 LPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEP 841
Query: 387 LSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYD-PRAIALHLTAGWMFWSDWNEKKPK 445
LS+ +YW D I VA DG + I+++ + D PRA+ L G MFW+DW + KP
Sbjct: 842 LSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPG 901
Query: 446 IERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSN 505
I R+N+DGS L+SE + WPN I++D + +YW DA IE G +R + N
Sbjct: 902 IYRSNMDGSAAYHLVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQQRSVILDN 959
Query: 506 DIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFRLGAPLGW 565
+ H + + ++ R +K +G + + Q+ +M +K F G G
Sbjct: 960 -LPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGS 1018
Query: 566 NPCADDNGGCSHLCFNRPDD-YICGCP 591
N C CS LC + ++ C CP
Sbjct: 1019 NACVP--RPCSLLCLPKANNSRSCRCP 1043
Score = 62.1 bits (144), Expect = 1e-08
Identities = 47/198 (23%), Positives = 82/198 (41%), Gaps = 10/198 (5%)
Query: 898 RLNKDNITC--SEPEEFLLFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQ 955
RL + + C +E EF+L+A + ++ R +A+G +PLTGL+ A+++D
Sbjct: 744 RLEGELVPCPLAEENEFILYAVRKSIYRYDLASGATEQ--LPLTGLRAAVALDFDYEHNC 801
Query: 956 LYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSIN 1015
LYW D I+R+ ++ GL + + L + +YW A I
Sbjct: 802 LYWSDLALDVIQRLCLN----GSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIE 857
Query: 1016 ATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVG--RGAIMRANVDGTGRVELAR 1073
+ D + ++ PR L + + W D G + I R+N+DG+ L
Sbjct: 858 VANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVS 917
Query: 1074 ADNATALALDQSAGTVYW 1091
D + +YW
Sbjct: 918 EDVKWPNGISVDDQWIYW 935
Score = 47.6 bits (108), Expect = 3e-04
Identities = 33/111 (29%), Positives = 41/111 (36%), Gaps = 16/111 (14%)
Query: 1084 QSAGTVYWAVSRQCDGQQDCEDGRDEAECGA--CGGD-VRCADGTXXXXX---------- 1130
Q +GT +S +CD + DC D DE+ C C D C+ G
Sbjct: 1126 QESGTCI-PLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCR 1184
Query: 1131 --XXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F+C G CI R+ CDG C DGSDE P C
Sbjct: 1185 DWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNC 1235
Score = 46.8 bits (106), Expect = 5e-04
Identities = 30/105 (28%), Positives = 40/105 (38%), Gaps = 23/105 (21%)
Query: 1094 SRQCDGQQDCEDGRDEAECG----------------------ACGGDVRCADGTXXXXXX 1131
S+ CDG +DC DG DE C C G ++C DG+
Sbjct: 1253 SKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAF 1312
Query: 1132 XXXXXXXXXXXXXXD-AFRCDEGLCIAARFVCDGRPQCADGSDEA 1175
+ F+C G+CI+ + CDG C D SDEA
Sbjct: 1313 AGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEA 1357
Score = 44.8 bits (101), Expect = 0.002
Identities = 30/92 (32%), Positives = 35/92 (38%), Gaps = 14/92 (15%)
Query: 1097 CDGQQDCEDGRDEAECGA----C-GGDVRCADGTXXXXXXXXXXXXXXXXXXXXD----- 1146
CDG DC D DEA C A C + +C +G D
Sbjct: 1177 CDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCE 1236
Query: 1147 ----AFRCDEGLCIAARFVCDGRPQCADGSDE 1174
FRC G CI + CDG C+DGSDE
Sbjct: 1237 KKCNGFRCPNGTCIPSSKHCDGLRDCSDGSDE 1268
Score = 42.7 bits (96), Expect = 0.008
Identities = 18/39 (46%), Positives = 22/39 (56%), Gaps = 1/39 (2%)
Query: 1146 DAFRCDEGLCIAARFVCDGRPQCADGSDEAPAACAYGHT 1184
D + C G+CI + +VCDG C D SDEA Y HT
Sbjct: 1161 DEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIY-HT 1198
Score = 41.9 bits (94), Expect = 0.013
Identities = 24/79 (30%), Positives = 31/79 (39%), Gaps = 15/79 (18%)
Query: 1096 QCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLC 1155
+CD + DC D DE +CG + +RC G C
Sbjct: 1387 KCDRENDCGDWSDEKDCG---------------DSHILPFSTPGPSTCLPNYYRCSSGTC 1431
Query: 1156 IAARFVCDGRPQCADGSDE 1174
+ +VCDG CADGSDE
Sbjct: 1432 VMDTWVCDGYRDCADGSDE 1450
Score = 39.1 bits (87), Expect = 0.094
Identities = 13/18 (72%), Positives = 16/18 (88%)
Query: 1095 RQCDGQQDCEDGRDEAEC 1112
++CDG QDC+DGRDEA C
Sbjct: 1489 KRCDGHQDCQDGRDEANC 1506
Score = 36.7 bits (81), Expect = 0.50
Identities = 39/167 (23%), Positives = 71/167 (42%), Gaps = 12/167 (7%)
Query: 928 NGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXX 987
NG I +GL+ V A+ ++P+ + LYW+D +++ ++
Sbjct: 818 NGSTGQEVIINSGLETVEALAFEPLSQLLYWVD---AGFKKIEVANPDGDFRLTIVNSSV 874
Query: 988 GLSRPYHMVLDVLGRTMYWT-CAD-RDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTK 1045
L RP +VL M+WT D + I +++D S+ +V D P ++
Sbjct: 875 -LDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMD-GSAAYHLVSEDVKWPNGISVDD-- 930
Query: 1046 RYLIWNDVGRGAIMRANVDGTGR-VELARADNATALALDQSAGTVYW 1091
+++ W D I R G R V L + A+A+ ++ +YW
Sbjct: 931 QWIYWTDAYLECIERITFSGQQRSVILDNLPHPYAIAVFKN--EIYW 975
Score = 35.5 bits (78), Expect = 1.2
Identities = 14/27 (51%), Positives = 16/27 (59%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDE 1174
FRC+ G CI R+ CD C D SDE
Sbjct: 1374 FRCENGHCIPNRWKCDRENDCGDWSDE 1400
Score = 34.3 bits (75), Expect = 2.7
Identities = 16/42 (38%), Positives = 20/42 (47%), Gaps = 1/42 (2%)
Query: 1148 FRCDE-GLCIAARFVCDGRPQCADGSDEAPAACAYGHTDQVN 1188
FRC E G CI + CD C D SDE+ +D+ N
Sbjct: 1123 FRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYN 1164
>U60975-1|AAC50891.2| 2214|Homo sapiens gp250 precursor protein.
Length = 2214
Score = 158 bits (384), Expect = 1e-37
Identities = 100/319 (31%), Positives = 164/319 (51%), Gaps = 17/319 (5%)
Query: 605 EPEAFLVYSRKNIIGRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINR 664
E F++Y+ + I R + + + +P+ L+ AL + LYWSD I R
Sbjct: 756 EENEFILYAVRKSIYRYDLASGATEQ-LPLTGLRAAVALDFDYEHNCLYWSDLALDVIQR 814
Query: 665 CSVNGSAVEKIVEWLGL--VEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQG- 721
+NGS ++++ GL VE LA + Q +YW D ++IEV+ DG R I+
Sbjct: 815 LCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSV 874
Query: 722 LKKPKSIVLDPKKGYMYWSELGS--KSIKRAAMDGSSV-SVFMEQVGRVHALAIDYERRA 778
L +P+++VL P++G M+W++ G I R+ MDGS+ + E V + +++D +
Sbjct: 875 LDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVDDQW-- 932
Query: 779 IYWAALDPPVVEFAFLNGTGRQTLADNIPMPYALALFNDSVYWGDWNTGQIQQARKTDGS 838
IYW +E +G R + DN+P PYA+A+F + +YW DW+ I +A K GS
Sbjct: 933 IYWTDAYLECIERITFSGQQRSVILDNLPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGS 992
Query: 839 NRKSIRKDLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYR 898
+ + L + D+K++++ K+ GSN C V CS LCLP + R+ C CP
Sbjct: 993 QMEILANQLTGLMDMKIFYKGKNTGSNAC-VPR-PCSLLCLPKANNSRS---CRCPEDVS 1047
Query: 899 ---LNKDNITCSEPEEFLL 914
L ++ C P+ + L
Sbjct: 1048 SSVLPSGDLMCDCPQGYQL 1066
Score = 149 bits (361), Expect = 6e-35
Identities = 92/274 (33%), Positives = 148/274 (54%), Gaps = 16/274 (5%)
Query: 17 LEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAIDWYTD 76
L A+DF Y N + WSD ++IQ + N + TG++ I++ GL T +A + +
Sbjct: 787 LRAAVALDFDYEHNCLYWSDLALDVIQRLCLNGS-TGQEV-IINSGLETVEALAFEPLSQ 844
Query: 77 KLYWTDGETNKIEVISIVQKYRKVLFWSEV-DLARAIAVVPEDGLMFWTDWGEI-PKIER 134
LYW D KIEV + +R + S V D RA+ +VP++G+MFWTDWG++ P I R
Sbjct: 845 LLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYR 904
Query: 135 AGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVKGG 194
+ M+G A +V +++ WPNGI+VD + IYW DA L+ ++ I F+G++R V+
Sbjct: 905 SNMDGSAAYH--LVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQQRS-VILDN 959
Query: 195 LVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESRQIIS 254
L +P+A+ +++YW DW SI+ +G +++ L D+K++ + + S
Sbjct: 960 LPHPYAIAVFKNEIYWDDWSQLSIFRAS-KYSGSQMEILANQLTGLMDMKIFYKGKNTGS 1018
Query: 255 AEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGV 288
P CS LCL + +C CP V
Sbjct: 1019 NACVP-----RPCSLLCLPKAN-NSRSCRCPEDV 1046
Score = 147 bits (356), Expect = 2e-34
Identities = 85/267 (31%), Positives = 135/267 (50%), Gaps = 9/267 (3%)
Query: 329 LPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGVP--DSIAIDP 386
LPL L+ + +DFD + +YW+D I + L+GS V+ +SG+ +++A +P
Sbjct: 782 LPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEP 841
Query: 387 LSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYD-PRAIALHLTAGWMFWSDWNEKKPK 445
LS+ +YW D I VA DG + I+++ + D PRA+ L G MFW+DW + KP
Sbjct: 842 LSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPG 901
Query: 446 IERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSN 505
I R+N+DGS L+SE + WPN I++D + +YW DA IE G +R + N
Sbjct: 902 IYRSNMDGSAAYHLVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQQRSVILDN 959
Query: 506 DIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMMGVKAFRLGAPLGW 565
+ H + + ++ R +K +G + + Q+ +M +K F G G
Sbjct: 960 -LPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGS 1018
Query: 566 NPCADDNGGCSHLCFNRPDD-YICGCP 591
N C CS LC + ++ C CP
Sbjct: 1019 NACVP--RPCSLLCLPKANNSRSCRCP 1043
Score = 62.1 bits (144), Expect = 1e-08
Identities = 47/198 (23%), Positives = 82/198 (41%), Gaps = 10/198 (5%)
Query: 898 RLNKDNITC--SEPEEFLLFAQKNAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQ 955
RL + + C +E EF+L+A + ++ R +A+G +PLTGL+ A+++D
Sbjct: 744 RLEGELVPCPLAEENEFILYAVRKSIYRYDLASGATEQ--LPLTGLRAAVALDFDYEHNC 801
Query: 956 LYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSIN 1015
LYW D I+R+ ++ GL + + L + +YW A I
Sbjct: 802 LYWSDLALDVIQRLCLN----GSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIE 857
Query: 1016 ATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVG--RGAIMRANVDGTGRVELAR 1073
+ D + ++ PR L + + W D G + I R+N+DG+ L
Sbjct: 858 VANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVS 917
Query: 1074 ADNATALALDQSAGTVYW 1091
D + +YW
Sbjct: 918 EDVKWPNGISVDDQWIYW 935
Score = 47.6 bits (108), Expect = 3e-04
Identities = 33/111 (29%), Positives = 41/111 (36%), Gaps = 16/111 (14%)
Query: 1084 QSAGTVYWAVSRQCDGQQDCEDGRDEAECGA--CGGD-VRCADGTXXXXX---------- 1130
Q +GT +S +CD + DC D DE+ C C D C+ G
Sbjct: 1126 QESGTCI-PLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCR 1184
Query: 1131 --XXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F+C G CI R+ CDG C DGSDE P C
Sbjct: 1185 DWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNC 1235
Score = 46.8 bits (106), Expect = 5e-04
Identities = 30/105 (28%), Positives = 40/105 (38%), Gaps = 23/105 (21%)
Query: 1094 SRQCDGQQDCEDGRDEAECG----------------------ACGGDVRCADGTXXXXXX 1131
S+ CDG +DC DG DE C C G ++C DG+
Sbjct: 1253 SKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAF 1312
Query: 1132 XXXXXXXXXXXXXXD-AFRCDEGLCIAARFVCDGRPQCADGSDEA 1175
+ F+C G+CI+ + CDG C D SDEA
Sbjct: 1313 AGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEA 1357
Score = 44.8 bits (101), Expect = 0.002
Identities = 30/92 (32%), Positives = 35/92 (38%), Gaps = 14/92 (15%)
Query: 1097 CDGQQDCEDGRDEAECGA----C-GGDVRCADGTXXXXXXXXXXXXXXXXXXXXD----- 1146
CDG DC D DEA C A C + +C +G D
Sbjct: 1177 CDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCE 1236
Query: 1147 ----AFRCDEGLCIAARFVCDGRPQCADGSDE 1174
FRC G CI + CDG C+DGSDE
Sbjct: 1237 KKCNGFRCPNGTCIPSSKHCDGLRDCSDGSDE 1268
Score = 42.7 bits (96), Expect = 0.008
Identities = 18/39 (46%), Positives = 22/39 (56%), Gaps = 1/39 (2%)
Query: 1146 DAFRCDEGLCIAARFVCDGRPQCADGSDEAPAACAYGHT 1184
D + C G+CI + +VCDG C D SDEA Y HT
Sbjct: 1161 DEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIY-HT 1198
Score = 41.9 bits (94), Expect = 0.013
Identities = 24/79 (30%), Positives = 31/79 (39%), Gaps = 15/79 (18%)
Query: 1096 QCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLC 1155
+CD + DC D DE +CG + +RC G C
Sbjct: 1387 KCDRENDCGDWSDEKDCG---------------DSHILPFSTPGPSTCLPNYYRCSSGTC 1431
Query: 1156 IAARFVCDGRPQCADGSDE 1174
+ +VCDG CADGSDE
Sbjct: 1432 VMDTWVCDGYRDCADGSDE 1450
Score = 39.1 bits (87), Expect = 0.094
Identities = 13/18 (72%), Positives = 16/18 (88%)
Query: 1095 RQCDGQQDCEDGRDEAEC 1112
++CDG QDC+DGRDEA C
Sbjct: 1489 KRCDGHQDCQDGRDEANC 1506
Score = 36.7 bits (81), Expect = 0.50
Identities = 39/167 (23%), Positives = 71/167 (42%), Gaps = 12/167 (7%)
Query: 928 NGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXX 987
NG I +GL+ V A+ ++P+ + LYW+D +++ ++
Sbjct: 818 NGSTGQEVIINSGLETVEALAFEPLSQLLYWVD---AGFKKIEVANPDGDFRLTIVNSSV 874
Query: 988 GLSRPYHMVLDVLGRTMYWT-CAD-RDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTK 1045
L RP +VL M+WT D + I +++D S+ +V D P ++
Sbjct: 875 -LDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMD-GSAAYHLVSEDVKWPNGISVDD-- 930
Query: 1046 RYLIWNDVGRGAIMRANVDGTGR-VELARADNATALALDQSAGTVYW 1091
+++ W D I R G R V L + A+A+ ++ +YW
Sbjct: 931 QWIYWTDAYLECIERITFSGQQRSVILDNLPHPYAIAVFKN--EIYW 975
Score = 35.5 bits (78), Expect = 1.2
Identities = 14/27 (51%), Positives = 16/27 (59%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDE 1174
FRC+ G CI R+ CD C D SDE
Sbjct: 1374 FRCENGHCIPNRWKCDRENDCGDWSDE 1400
Score = 34.3 bits (75), Expect = 2.7
Identities = 16/42 (38%), Positives = 20/42 (47%), Gaps = 1/42 (2%)
Query: 1148 FRCDE-GLCIAARFVCDGRPQCADGSDEAPAACAYGHTDQVN 1188
FRC E G CI + CD C D SDE+ +D+ N
Sbjct: 1123 FRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYN 1164
>M27445-1|AAA57261.1| 581|Homo sapiens nidogen protein.
Length = 581
Score = 156 bits (378), Expect = 5e-37
Identities = 83/255 (32%), Positives = 129/255 (50%), Gaps = 9/255 (3%)
Query: 342 FDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSS-GVPDSIAIDPLSRKIYWTDPVMDT 400
FD + +YW D +I +A L G + + ++R G P+ IA+D L R I+WTD +D
Sbjct: 319 FDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDR 378
Query: 401 INVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLI 460
I VA+LDG+ +V+ T+L +PR I G ++W+DWN PKIE + +DG+ R +L+
Sbjct: 379 IEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILV 438
Query: 461 SEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXXXXXX 520
+ L PN + D +++L W DA T++ E N R++ + + F
Sbjct: 439 QDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSYGKNL 497
Query: 521 XXXXMQKRT---LD-RINKNTGLDRQPVVEQMANMMGVKAFRLGAPLGWNPCADDNGGCS 576
+ + LD I+K T QP + + G+ P G N C+ +NGGC+
Sbjct: 498 YFTDWKMNSVVALDLAISKETDAF-QP--HKQTRLYGITTALSQCPQGHNYCSVNNGGCT 554
Query: 577 HLCFNRPDDYICGCP 591
HLC P C CP
Sbjct: 555 HLCLATPGSRTCRCP 569
Score = 138 bits (335), Expect = 8e-32
Identities = 78/234 (33%), Positives = 125/234 (53%), Gaps = 9/234 (3%)
Query: 53 GEKFKIVSEGLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAI 112
GE I+ + L +P GIA+D ++WTD ++IEV + R+VLF +++ R I
Sbjct: 344 GEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGI 403
Query: 113 AVVPEDGLMFWTDWG-EIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVD 171
G ++WTDW + PKIE + M+G R+++V+D++ PNG+T D +S + WVD
Sbjct: 404 VTDSVRGNLYWTDWNRDNPKIETSYMDG--TNRRILVQDDLGLPNGLTFDAFSSQLCWVD 461
Query: 172 AKLQFVDVIDFNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIK 231
A + ++ + R++ ++ GL YPFA+T LY+TDW+ S+ D+A + K
Sbjct: 462 AGTNRAECLNPSQPSRRKALE-GLQYPFAVTSYGKNLYFTDWKMNSVVALDLAIS--KET 518
Query: 232 ELIKSHPVPADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACP 285
+ + H + Q +Y C NN GC+HLCL +P C CP
Sbjct: 519 DAFQPHKQTRLYGITTALSQCPQGHNY-CSVNNGGCTHLCLATPG--SRTCRCP 569
Score = 128 bits (309), Expect = 1e-28
Identities = 75/262 (28%), Positives = 124/262 (47%), Gaps = 9/262 (3%)
Query: 638 KEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEW-LGLVEGLAIDWSGQNIYW 696
K + LA +YW+D +I R S++G I+ LG EG+A+D G+NI+W
Sbjct: 312 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFW 371
Query: 697 TDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELG--SKSIKRAAMDG 754
TD+ RIEV++LDG+ RR + L P+ IV D +G +YW++ + I+ + MDG
Sbjct: 372 TDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDG 431
Query: 755 SSVSVFM-EQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPMPYALA 813
++ + + + +G + L D + W E + R+ + + P+A+
Sbjct: 432 TNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVT 491
Query: 814 LFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLD-YISDLKLYHRAKSMGSNQCGVDNG 872
+ ++Y+ DW + + + + + G N C V+NG
Sbjct: 492 SYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNG 551
Query: 873 GCSHLCLPTPGDVRTDYRCACP 894
GC+HLCL TPG RT C CP
Sbjct: 552 GCTHLCLATPGS-RT---CRCP 569
Score = 58.8 bits (136), Expect = 1e-07
Identities = 29/98 (29%), Positives = 49/98 (50%), Gaps = 2/98 (2%)
Query: 412 KVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIA 471
K +H +A ++W+D E P I RA+L G +I + L P IA
Sbjct: 304 KAFLHVPAKVIIGLAFDCVDKMVYWTDITE--PSIGRASLHGGEPTTIIRQDLGSPEGIA 361
Query: 472 LDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDIIH 509
+D + ++W D+ +IEV +DGT+R+ L D+++
Sbjct: 362 VDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVN 399
Score = 56.4 bits (130), Expect = 6e-07
Identities = 37/145 (25%), Positives = 64/145 (44%), Gaps = 4/145 (2%)
Query: 603 CVEPEAFLVYSRKNIIGRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTI 662
CV+ + + IGR S+ +I +DL +A+ G ++W+DS I
Sbjct: 321 CVDKMVYWTDITEPSIGRASLHGGEPTTIIR-QDLGSPEGIAVDHLGRNIFWTDSNLDRI 379
Query: 663 NRCSVNGSAVEKIVEW-LGLVEGLAIDWSGQNIYWTD--TTTQRIEVSRLDGSSRRAIIW 719
++G+ + E L G+ D N+YWTD +IE S +DG++RR ++
Sbjct: 380 EVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQ 439
Query: 720 QGLKKPKSIVLDPKKGYMYWSELGS 744
L P + D + W + G+
Sbjct: 440 DDLGLPNGLTFDAFSSQLCWVDAGT 464
Score = 52.0 bits (119), Expect = 1e-05
Identities = 47/191 (24%), Positives = 76/191 (39%), Gaps = 15/191 (7%)
Query: 909 PEEFLLFAQKNAVGRIMVANGECND----AYIPLTGLKNVRAIEYDPVEKQLYWMDDDSH 964
P LLFAQ + R+ + A++ + K + + +D V+K +YW D
Sbjct: 276 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPA-KVIIGLAFDCVDKMVYWTDITEP 334
Query: 965 SIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSS 1024
SI R + L P + +D LGR ++WT ++ D I +D +
Sbjct: 335 SIGRASLH-----GGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLD-GTQ 388
Query: 1025 TGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRG--AIMRANVDGTGRVELARADNA--TAL 1080
V+ D + PR + + L W D R I + +DGT R L + D L
Sbjct: 389 RRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGL 448
Query: 1081 ALDQSAGTVYW 1091
D + + W
Sbjct: 449 TFDAFSSQLCW 459
Score = 51.2 bits (117), Expect = 2e-05
Identities = 38/167 (22%), Positives = 71/167 (42%), Gaps = 8/167 (4%)
Query: 326 PYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGV-PDSIAI 384
P T+ +DL + D I+W D I A+LDG+ + V+ + V P I
Sbjct: 346 PTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVT 405
Query: 385 DPLSRKIYWTDPVMDT--INVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEK 442
D + +YWTD D I + +DG+ ++++ +L P + + + W D
Sbjct: 406 DSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTN 465
Query: 443 KPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKI 489
+ + + + L E L +P A+ + LY+ D + + +
Sbjct: 466 RAECLNPSQPSRRKAL---EGLQYP--FAVTSYGKNLYFTDWKMNSV 507
Score = 50.8 bits (116), Expect = 3e-05
Identities = 40/149 (26%), Positives = 64/149 (42%), Gaps = 7/149 (4%)
Query: 68 GIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWG 127
G+A D +YWTD I S+ + ++ IAV +FWTD
Sbjct: 316 GLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTD-S 374
Query: 128 EIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQ--FVDVIDFNGE 185
+ +IE A ++G R+V+ ++ P GI D +YW D ++ +G
Sbjct: 375 NLDRIEVAKLDG--TQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGT 432
Query: 186 KRKRVVKGGLVYPFALTFS--NDKLYWTD 212
R+ +V+ L P LTF + +L W D
Sbjct: 433 NRRILVQDDLGLPNGLTFDAFSSQLCWVD 461
Score = 37.5 bits (83), Expect = 0.29
Identities = 32/136 (23%), Positives = 56/136 (41%), Gaps = 8/136 (5%)
Query: 920 AVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXX 979
++GR + GE I L + I D + + ++W D + + R+ ++
Sbjct: 335 SIGRASLHGGE--PTTIIRQDLGSPEGIAVDHLGRNIFWTDSN---LDRIEVA--KLDGT 387
Query: 980 XXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINA-TSIDNNSSTGVIVRGDRMLPRH 1038
L P +V D + +YWT +RD+ TS + ++ ++V+ D LP
Sbjct: 388 QRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNG 447
Query: 1039 LAFHQTKRYLIWNDVG 1054
L F L W D G
Sbjct: 448 LTFDAFSSQLCWVDAG 463
>BC045606-1|AAH45606.1| 1114|Homo sapiens NID1 protein protein.
Length = 1114
Score = 156 bits (378), Expect = 5e-37
Identities = 83/255 (32%), Positives = 129/255 (50%), Gaps = 9/255 (3%)
Query: 342 FDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSS-GVPDSIAIDPLSRKIYWTDPVMDT 400
FD + +YW D +I +A L G + + ++R G P+ IA+D L R I+WTD +D
Sbjct: 852 FDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDR 911
Query: 401 INVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLI 460
I VA+LDG+ +V+ T+L +PR I G ++W+DWN PKIE + +DG+ R +L+
Sbjct: 912 IEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILV 971
Query: 461 SEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXXXXXX 520
+ L PN + D +++L W DA T++ E N R++ + + F
Sbjct: 972 QDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSYGKNL 1030
Query: 521 XXXXMQKRT---LD-RINKNTGLDRQPVVEQMANMMGVKAFRLGAPLGWNPCADDNGGCS 576
+ + LD I+K T QP + + G+ P G N C+ +NGGC+
Sbjct: 1031 YFTDWKMNSVVALDLAISKETDAF-QP--HKQTRLYGITTALSQCPQGHNYCSVNNGGCT 1087
Query: 577 HLCFNRPDDYICGCP 591
HLC P C CP
Sbjct: 1088 HLCLATPGSRTCRCP 1102
Score = 138 bits (335), Expect = 8e-32
Identities = 78/234 (33%), Positives = 125/234 (53%), Gaps = 9/234 (3%)
Query: 53 GEKFKIVSEGLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAI 112
GE I+ + L +P GIA+D ++WTD ++IEV + R+VLF +++ R I
Sbjct: 877 GEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGI 936
Query: 113 AVVPEDGLMFWTDWG-EIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVD 171
G ++WTDW + PKIE + M+G R+++V+D++ PNG+T D +S + WVD
Sbjct: 937 VTDSVRGNLYWTDWNRDNPKIETSYMDG--TNRRILVQDDLGLPNGLTFDAFSSQLCWVD 994
Query: 172 AKLQFVDVIDFNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIK 231
A + ++ + R++ ++ GL YPFA+T LY+TDW+ S+ D+A + K
Sbjct: 995 AGTNRAECLNPSQPSRRKALE-GLQYPFAVTSYGKNLYFTDWKMNSVVALDLAIS--KET 1051
Query: 232 ELIKSHPVPADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACP 285
+ + H + Q +Y C NN GC+HLCL +P C CP
Sbjct: 1052 DAFQPHKQTRLYGITTALSQCPQGHNY-CSVNNGGCTHLCLATPG--SRTCRCP 1102
Score = 128 bits (309), Expect = 1e-28
Identities = 75/262 (28%), Positives = 124/262 (47%), Gaps = 9/262 (3%)
Query: 638 KEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEW-LGLVEGLAIDWSGQNIYW 696
K + LA +YW+D +I R S++G I+ LG EG+A+D G+NI+W
Sbjct: 845 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFW 904
Query: 697 TDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELG--SKSIKRAAMDG 754
TD+ RIEV++LDG+ RR + L P+ IV D +G +YW++ + I+ + MDG
Sbjct: 905 TDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDG 964
Query: 755 SSVSVFM-EQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPMPYALA 813
++ + + + +G + L D + W E + R+ + + P+A+
Sbjct: 965 TNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVT 1024
Query: 814 LFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLD-YISDLKLYHRAKSMGSNQCGVDNG 872
+ ++Y+ DW + + + + + G N C V+NG
Sbjct: 1025 SYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNG 1084
Query: 873 GCSHLCLPTPGDVRTDYRCACP 894
GC+HLCL TPG RT C CP
Sbjct: 1085 GCTHLCLATPGS-RT---CRCP 1102
Score = 58.8 bits (136), Expect = 1e-07
Identities = 29/98 (29%), Positives = 49/98 (50%), Gaps = 2/98 (2%)
Query: 412 KVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIA 471
K +H +A ++W+D E P I RA+L G +I + L P IA
Sbjct: 837 KAFLHVPAKVIIGLAFDCVDKMVYWTDITE--PSIGRASLHGGEPTTIIRQDLGSPEGIA 894
Query: 472 LDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDIIH 509
+D + ++W D+ +IEV +DGT+R+ L D+++
Sbjct: 895 VDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVN 932
Score = 56.4 bits (130), Expect = 6e-07
Identities = 37/145 (25%), Positives = 64/145 (44%), Gaps = 4/145 (2%)
Query: 603 CVEPEAFLVYSRKNIIGRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTI 662
CV+ + + IGR S+ +I +DL +A+ G ++W+DS I
Sbjct: 854 CVDKMVYWTDITEPSIGRASLHGGEPTTIIR-QDLGSPEGIAVDHLGRNIFWTDSNLDRI 912
Query: 663 NRCSVNGSAVEKIVEW-LGLVEGLAIDWSGQNIYWTD--TTTQRIEVSRLDGSSRRAIIW 719
++G+ + E L G+ D N+YWTD +IE S +DG++RR ++
Sbjct: 913 EVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQ 972
Query: 720 QGLKKPKSIVLDPKKGYMYWSELGS 744
L P + D + W + G+
Sbjct: 973 DDLGLPNGLTFDAFSSQLCWVDAGT 997
Score = 52.0 bits (119), Expect = 1e-05
Identities = 47/191 (24%), Positives = 76/191 (39%), Gaps = 15/191 (7%)
Query: 909 PEEFLLFAQKNAVGRIMVANGECND----AYIPLTGLKNVRAIEYDPVEKQLYWMDDDSH 964
P LLFAQ + R+ + A++ + K + + +D V+K +YW D
Sbjct: 809 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPA-KVIIGLAFDCVDKMVYWTDITEP 867
Query: 965 SIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSS 1024
SI R + L P + +D LGR ++WT ++ D I +D +
Sbjct: 868 SIGRASLH-----GGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLD-GTQ 921
Query: 1025 TGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRG--AIMRANVDGTGRVELARADNA--TAL 1080
V+ D + PR + + L W D R I + +DGT R L + D L
Sbjct: 922 RRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGL 981
Query: 1081 ALDQSAGTVYW 1091
D + + W
Sbjct: 982 TFDAFSSQLCW 992
Score = 51.2 bits (117), Expect = 2e-05
Identities = 38/167 (22%), Positives = 71/167 (42%), Gaps = 8/167 (4%)
Query: 326 PYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGV-PDSIAI 384
P T+ +DL + D I+W D I A+LDG+ + V+ + V P I
Sbjct: 879 PTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVT 938
Query: 385 DPLSRKIYWTDPVMDT--INVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEK 442
D + +YWTD D I + +DG+ ++++ +L P + + + W D
Sbjct: 939 DSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTN 998
Query: 443 KPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKI 489
+ + + + L E L +P A+ + LY+ D + + +
Sbjct: 999 RAECLNPSQPSRRKAL---EGLQYP--FAVTSYGKNLYFTDWKMNSV 1040
Score = 50.8 bits (116), Expect = 3e-05
Identities = 40/149 (26%), Positives = 64/149 (42%), Gaps = 7/149 (4%)
Query: 68 GIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWG 127
G+A D +YWTD I S+ + ++ IAV +FWTD
Sbjct: 849 GLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTD-S 907
Query: 128 EIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQ--FVDVIDFNGE 185
+ +IE A ++G R+V+ ++ P GI D +YW D ++ +G
Sbjct: 908 NLDRIEVAKLDG--TQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGT 965
Query: 186 KRKRVVKGGLVYPFALTFS--NDKLYWTD 212
R+ +V+ L P LTF + +L W D
Sbjct: 966 NRRILVQDDLGLPNGLTFDAFSSQLCWVD 994
Score = 37.5 bits (83), Expect = 0.29
Identities = 32/136 (23%), Positives = 56/136 (41%), Gaps = 8/136 (5%)
Query: 920 AVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXX 979
++GR + GE I L + I D + + ++W D + + R+ ++
Sbjct: 868 SIGRASLHGGE--PTTIIRQDLGSPEGIAVDHLGRNIFWTDSN---LDRIEVA--KLDGT 920
Query: 980 XXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINA-TSIDNNSSTGVIVRGDRMLPRH 1038
L P +V D + +YWT +RD+ TS + ++ ++V+ D LP
Sbjct: 921 QRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNG 980
Query: 1039 LAFHQTKRYLIWNDVG 1054
L F L W D G
Sbjct: 981 LTFDAFSSQLCWVDAG 996
>AL139161-2|CAI23422.1| 1247|Homo sapiens nidogen 1 protein.
Length = 1247
Score = 156 bits (378), Expect = 5e-37
Identities = 83/255 (32%), Positives = 129/255 (50%), Gaps = 9/255 (3%)
Query: 342 FDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSS-GVPDSIAIDPLSRKIYWTDPVMDT 400
FD + +YW D +I +A L G + + ++R G P+ IA+D L R I+WTD +D
Sbjct: 985 FDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDR 1044
Query: 401 INVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLI 460
I VA+LDG+ +V+ T+L +PR I G ++W+DWN PKIE + +DG+ R +L+
Sbjct: 1045 IEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILV 1104
Query: 461 SEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXXXXXX 520
+ L PN + D +++L W DA T++ E N R++ + + F
Sbjct: 1105 QDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSYGKNL 1163
Query: 521 XXXXMQKRT---LD-RINKNTGLDRQPVVEQMANMMGVKAFRLGAPLGWNPCADDNGGCS 576
+ + LD I+K T QP + + G+ P G N C+ +NGGC+
Sbjct: 1164 YFTDWKMNSVVALDLAISKETDAF-QP--HKQTRLYGITTALSQCPQGHNYCSVNNGGCT 1220
Query: 577 HLCFNRPDDYICGCP 591
HLC P C CP
Sbjct: 1221 HLCLATPGSRTCRCP 1235
Score = 138 bits (335), Expect = 8e-32
Identities = 78/234 (33%), Positives = 125/234 (53%), Gaps = 9/234 (3%)
Query: 53 GEKFKIVSEGLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAI 112
GE I+ + L +P GIA+D ++WTD ++IEV + R+VLF +++ R I
Sbjct: 1010 GEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGI 1069
Query: 113 AVVPEDGLMFWTDWG-EIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVD 171
G ++WTDW + PKIE + M+G R+++V+D++ PNG+T D +S + WVD
Sbjct: 1070 VTDSVRGNLYWTDWNRDNPKIETSYMDG--TNRRILVQDDLGLPNGLTFDAFSSQLCWVD 1127
Query: 172 AKLQFVDVIDFNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIK 231
A + ++ + R++ ++ GL YPFA+T LY+TDW+ S+ D+A + K
Sbjct: 1128 AGTNRAECLNPSQPSRRKALE-GLQYPFAVTSYGKNLYFTDWKMNSVVALDLAIS--KET 1184
Query: 232 ELIKSHPVPADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACP 285
+ + H + Q +Y C NN GC+HLCL +P C CP
Sbjct: 1185 DAFQPHKQTRLYGITTALSQCPQGHNY-CSVNNGGCTHLCLATPG--SRTCRCP 1235
Score = 128 bits (309), Expect = 1e-28
Identities = 75/262 (28%), Positives = 124/262 (47%), Gaps = 9/262 (3%)
Query: 638 KEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEW-LGLVEGLAIDWSGQNIYW 696
K + LA +YW+D +I R S++G I+ LG EG+A+D G+NI+W
Sbjct: 978 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFW 1037
Query: 697 TDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELG--SKSIKRAAMDG 754
TD+ RIEV++LDG+ RR + L P+ IV D +G +YW++ + I+ + MDG
Sbjct: 1038 TDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDG 1097
Query: 755 SSVSVFM-EQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPMPYALA 813
++ + + + +G + L D + W E + R+ + + P+A+
Sbjct: 1098 TNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVT 1157
Query: 814 LFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLD-YISDLKLYHRAKSMGSNQCGVDNG 872
+ ++Y+ DW + + + + + G N C V+NG
Sbjct: 1158 SYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNG 1217
Query: 873 GCSHLCLPTPGDVRTDYRCACP 894
GC+HLCL TPG RT C CP
Sbjct: 1218 GCTHLCLATPGS-RT---CRCP 1235
Score = 58.8 bits (136), Expect = 1e-07
Identities = 29/98 (29%), Positives = 49/98 (50%), Gaps = 2/98 (2%)
Query: 412 KVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIA 471
K +H +A ++W+D E P I RA+L G +I + L P IA
Sbjct: 970 KAFLHVPAKVIIGLAFDCVDKMVYWTDITE--PSIGRASLHGGEPTTIIRQDLGSPEGIA 1027
Query: 472 LDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDIIH 509
+D + ++W D+ +IEV +DGT+R+ L D+++
Sbjct: 1028 VDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVN 1065
Score = 56.4 bits (130), Expect = 6e-07
Identities = 37/145 (25%), Positives = 64/145 (44%), Gaps = 4/145 (2%)
Query: 603 CVEPEAFLVYSRKNIIGRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTI 662
CV+ + + IGR S+ +I +DL +A+ G ++W+DS I
Sbjct: 987 CVDKMVYWTDITEPSIGRASLHGGEPTTIIR-QDLGSPEGIAVDHLGRNIFWTDSNLDRI 1045
Query: 663 NRCSVNGSAVEKIVEW-LGLVEGLAIDWSGQNIYWTD--TTTQRIEVSRLDGSSRRAIIW 719
++G+ + E L G+ D N+YWTD +IE S +DG++RR ++
Sbjct: 1046 EVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQ 1105
Query: 720 QGLKKPKSIVLDPKKGYMYWSELGS 744
L P + D + W + G+
Sbjct: 1106 DDLGLPNGLTFDAFSSQLCWVDAGT 1130
Score = 52.0 bits (119), Expect = 1e-05
Identities = 47/191 (24%), Positives = 76/191 (39%), Gaps = 15/191 (7%)
Query: 909 PEEFLLFAQKNAVGRIMVANGECND----AYIPLTGLKNVRAIEYDPVEKQLYWMDDDSH 964
P LLFAQ + R+ + A++ + K + + +D V+K +YW D
Sbjct: 942 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPA-KVIIGLAFDCVDKMVYWTDITEP 1000
Query: 965 SIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSS 1024
SI R + L P + +D LGR ++WT ++ D I +D +
Sbjct: 1001 SIGRASLH-----GGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLD-GTQ 1054
Query: 1025 TGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRG--AIMRANVDGTGRVELARADNA--TAL 1080
V+ D + PR + + L W D R I + +DGT R L + D L
Sbjct: 1055 RRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGL 1114
Query: 1081 ALDQSAGTVYW 1091
D + + W
Sbjct: 1115 TFDAFSSQLCW 1125
Score = 51.2 bits (117), Expect = 2e-05
Identities = 38/167 (22%), Positives = 71/167 (42%), Gaps = 8/167 (4%)
Query: 326 PYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGV-PDSIAI 384
P T+ +DL + D I+W D I A+LDG+ + V+ + V P I
Sbjct: 1012 PTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVT 1071
Query: 385 DPLSRKIYWTDPVMDT--INVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEK 442
D + +YWTD D I + +DG+ ++++ +L P + + + W D
Sbjct: 1072 DSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTN 1131
Query: 443 KPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKI 489
+ + + + L E L +P A+ + LY+ D + + +
Sbjct: 1132 RAECLNPSQPSRRKAL---EGLQYP--FAVTSYGKNLYFTDWKMNSV 1173
Score = 50.8 bits (116), Expect = 3e-05
Identities = 40/149 (26%), Positives = 64/149 (42%), Gaps = 7/149 (4%)
Query: 68 GIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWG 127
G+A D +YWTD I S+ + ++ IAV +FWTD
Sbjct: 982 GLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTD-S 1040
Query: 128 EIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQ--FVDVIDFNGE 185
+ +IE A ++G R+V+ ++ P GI D +YW D ++ +G
Sbjct: 1041 NLDRIEVAKLDG--TQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGT 1098
Query: 186 KRKRVVKGGLVYPFALTFS--NDKLYWTD 212
R+ +V+ L P LTF + +L W D
Sbjct: 1099 NRRILVQDDLGLPNGLTFDAFSSQLCWVD 1127
Score = 37.5 bits (83), Expect = 0.29
Identities = 32/136 (23%), Positives = 56/136 (41%), Gaps = 8/136 (5%)
Query: 920 AVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXX 979
++GR + GE I L + I D + + ++W D + + R+ ++
Sbjct: 1001 SIGRASLHGGE--PTTIIRQDLGSPEGIAVDHLGRNIFWTDSN---LDRIEVA--KLDGT 1053
Query: 980 XXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINA-TSIDNNSSTGVIVRGDRMLPRH 1038
L P +V D + +YWT +RD+ TS + ++ ++V+ D LP
Sbjct: 1054 QRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNG 1113
Query: 1039 LAFHQTKRYLIWNDVG 1054
L F L W D G
Sbjct: 1114 LTFDAFSSQLCWVDAG 1129
>AL139161-1|CAI23421.1| 1114|Homo sapiens nidogen 1 protein.
Length = 1114
Score = 156 bits (378), Expect = 5e-37
Identities = 83/255 (32%), Positives = 129/255 (50%), Gaps = 9/255 (3%)
Query: 342 FDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSS-GVPDSIAIDPLSRKIYWTDPVMDT 400
FD + +YW D +I +A L G + + ++R G P+ IA+D L R I+WTD +D
Sbjct: 852 FDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDR 911
Query: 401 INVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLI 460
I VA+LDG+ +V+ T+L +PR I G ++W+DWN PKIE + +DG+ R +L+
Sbjct: 912 IEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILV 971
Query: 461 SEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXXXXXX 520
+ L PN + D +++L W DA T++ E N R++ + + F
Sbjct: 972 QDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSYGKNL 1030
Query: 521 XXXXMQKRT---LD-RINKNTGLDRQPVVEQMANMMGVKAFRLGAPLGWNPCADDNGGCS 576
+ + LD I+K T QP + + G+ P G N C+ +NGGC+
Sbjct: 1031 YFTDWKMNSVVALDLAISKETDAF-QP--HKQTRLYGITTALSQCPQGHNYCSVNNGGCT 1087
Query: 577 HLCFNRPDDYICGCP 591
HLC P C CP
Sbjct: 1088 HLCLATPGSRTCRCP 1102
Score = 138 bits (335), Expect = 8e-32
Identities = 78/234 (33%), Positives = 125/234 (53%), Gaps = 9/234 (3%)
Query: 53 GEKFKIVSEGLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAI 112
GE I+ + L +P GIA+D ++WTD ++IEV + R+VLF +++ R I
Sbjct: 877 GEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGI 936
Query: 113 AVVPEDGLMFWTDWG-EIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVD 171
G ++WTDW + PKIE + M+G R+++V+D++ PNG+T D +S + WVD
Sbjct: 937 VTDSVRGNLYWTDWNRDNPKIETSYMDG--TNRRILVQDDLGLPNGLTFDAFSSQLCWVD 994
Query: 172 AKLQFVDVIDFNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIK 231
A + ++ + R++ ++ GL YPFA+T LY+TDW+ S+ D+A + K
Sbjct: 995 AGTNRAECLNPSQPSRRKALE-GLQYPFAVTSYGKNLYFTDWKMNSVVALDLAIS--KET 1051
Query: 232 ELIKSHPVPADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACP 285
+ + H + Q +Y C NN GC+HLCL +P C CP
Sbjct: 1052 DAFQPHKQTRLYGITTALSQCPQGHNY-CSVNNGGCTHLCLATPG--SRTCRCP 1102
Score = 128 bits (309), Expect = 1e-28
Identities = 75/262 (28%), Positives = 124/262 (47%), Gaps = 9/262 (3%)
Query: 638 KEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEW-LGLVEGLAIDWSGQNIYW 696
K + LA +YW+D +I R S++G I+ LG EG+A+D G+NI+W
Sbjct: 845 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFW 904
Query: 697 TDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELG--SKSIKRAAMDG 754
TD+ RIEV++LDG+ RR + L P+ IV D +G +YW++ + I+ + MDG
Sbjct: 905 TDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDG 964
Query: 755 SSVSVFM-EQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPMPYALA 813
++ + + + +G + L D + W E + R+ + + P+A+
Sbjct: 965 TNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVT 1024
Query: 814 LFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLD-YISDLKLYHRAKSMGSNQCGVDNG 872
+ ++Y+ DW + + + + + G N C V+NG
Sbjct: 1025 SYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNG 1084
Query: 873 GCSHLCLPTPGDVRTDYRCACP 894
GC+HLCL TPG RT C CP
Sbjct: 1085 GCTHLCLATPGS-RT---CRCP 1102
Score = 58.8 bits (136), Expect = 1e-07
Identities = 29/98 (29%), Positives = 49/98 (50%), Gaps = 2/98 (2%)
Query: 412 KVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIA 471
K +H +A ++W+D E P I RA+L G +I + L P IA
Sbjct: 837 KAFLHVPAKVIIGLAFDCVDKMVYWTDITE--PSIGRASLHGGEPTTIIRQDLGSPEGIA 894
Query: 472 LDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDIIH 509
+D + ++W D+ +IEV +DGT+R+ L D+++
Sbjct: 895 VDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVN 932
Score = 56.4 bits (130), Expect = 6e-07
Identities = 37/145 (25%), Positives = 64/145 (44%), Gaps = 4/145 (2%)
Query: 603 CVEPEAFLVYSRKNIIGRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTI 662
CV+ + + IGR S+ +I +DL +A+ G ++W+DS I
Sbjct: 854 CVDKMVYWTDITEPSIGRASLHGGEPTTIIR-QDLGSPEGIAVDHLGRNIFWTDSNLDRI 912
Query: 663 NRCSVNGSAVEKIVEW-LGLVEGLAIDWSGQNIYWTD--TTTQRIEVSRLDGSSRRAIIW 719
++G+ + E L G+ D N+YWTD +IE S +DG++RR ++
Sbjct: 913 EVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQ 972
Query: 720 QGLKKPKSIVLDPKKGYMYWSELGS 744
L P + D + W + G+
Sbjct: 973 DDLGLPNGLTFDAFSSQLCWVDAGT 997
Score = 52.0 bits (119), Expect = 1e-05
Identities = 47/191 (24%), Positives = 76/191 (39%), Gaps = 15/191 (7%)
Query: 909 PEEFLLFAQKNAVGRIMVANGECND----AYIPLTGLKNVRAIEYDPVEKQLYWMDDDSH 964
P LLFAQ + R+ + A++ + K + + +D V+K +YW D
Sbjct: 809 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPA-KVIIGLAFDCVDKMVYWTDITEP 867
Query: 965 SIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSS 1024
SI R + L P + +D LGR ++WT ++ D I +D +
Sbjct: 868 SIGRASLH-----GGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLD-GTQ 921
Query: 1025 TGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRG--AIMRANVDGTGRVELARADNA--TAL 1080
V+ D + PR + + L W D R I + +DGT R L + D L
Sbjct: 922 RRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGL 981
Query: 1081 ALDQSAGTVYW 1091
D + + W
Sbjct: 982 TFDAFSSQLCW 992
Score = 51.2 bits (117), Expect = 2e-05
Identities = 38/167 (22%), Positives = 71/167 (42%), Gaps = 8/167 (4%)
Query: 326 PYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGV-PDSIAI 384
P T+ +DL + D I+W D I A+LDG+ + V+ + V P I
Sbjct: 879 PTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVT 938
Query: 385 DPLSRKIYWTDPVMDT--INVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEK 442
D + +YWTD D I + +DG+ ++++ +L P + + + W D
Sbjct: 939 DSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTN 998
Query: 443 KPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKI 489
+ + + + L E L +P A+ + LY+ D + + +
Sbjct: 999 RAECLNPSQPSRRKAL---EGLQYP--FAVTSYGKNLYFTDWKMNSV 1040
Score = 50.8 bits (116), Expect = 3e-05
Identities = 40/149 (26%), Positives = 64/149 (42%), Gaps = 7/149 (4%)
Query: 68 GIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWG 127
G+A D +YWTD I S+ + ++ IAV +FWTD
Sbjct: 849 GLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTD-S 907
Query: 128 EIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQ--FVDVIDFNGE 185
+ +IE A ++G R+V+ ++ P GI D +YW D ++ +G
Sbjct: 908 NLDRIEVAKLDG--TQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGT 965
Query: 186 KRKRVVKGGLVYPFALTFS--NDKLYWTD 212
R+ +V+ L P LTF + +L W D
Sbjct: 966 NRRILVQDDLGLPNGLTFDAFSSQLCWVD 994
Score = 37.5 bits (83), Expect = 0.29
Identities = 32/136 (23%), Positives = 56/136 (41%), Gaps = 8/136 (5%)
Query: 920 AVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXX 979
++GR + GE I L + I D + + ++W D + + R+ ++
Sbjct: 868 SIGRASLHGGE--PTTIIRQDLGSPEGIAVDHLGRNIFWTDSN---LDRIEVA--KLDGT 920
Query: 980 XXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINA-TSIDNNSSTGVIVRGDRMLPRH 1038
L P +V D + +YWT +RD+ TS + ++ ++V+ D LP
Sbjct: 921 QRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNG 980
Query: 1039 LAFHQTKRYLIWNDVG 1054
L F L W D G
Sbjct: 981 LTFDAFSSQLCWVDAG 996
>AL122018-2|CAI22681.1| 1247|Homo sapiens nidogen 1 protein.
Length = 1247
Score = 156 bits (378), Expect = 5e-37
Identities = 83/255 (32%), Positives = 129/255 (50%), Gaps = 9/255 (3%)
Query: 342 FDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSS-GVPDSIAIDPLSRKIYWTDPVMDT 400
FD + +YW D +I +A L G + + ++R G P+ IA+D L R I+WTD +D
Sbjct: 985 FDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDR 1044
Query: 401 INVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLI 460
I VA+LDG+ +V+ T+L +PR I G ++W+DWN PKIE + +DG+ R +L+
Sbjct: 1045 IEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILV 1104
Query: 461 SEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXXXXXX 520
+ L PN + D +++L W DA T++ E N R++ + + F
Sbjct: 1105 QDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSYGKNL 1163
Query: 521 XXXXMQKRT---LD-RINKNTGLDRQPVVEQMANMMGVKAFRLGAPLGWNPCADDNGGCS 576
+ + LD I+K T QP + + G+ P G N C+ +NGGC+
Sbjct: 1164 YFTDWKMNSVVALDLAISKETDAF-QP--HKQTRLYGITTALSQCPQGHNYCSVNNGGCT 1220
Query: 577 HLCFNRPDDYICGCP 591
HLC P C CP
Sbjct: 1221 HLCLATPGSRTCRCP 1235
Score = 138 bits (335), Expect = 8e-32
Identities = 78/234 (33%), Positives = 125/234 (53%), Gaps = 9/234 (3%)
Query: 53 GEKFKIVSEGLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAI 112
GE I+ + L +P GIA+D ++WTD ++IEV + R+VLF +++ R I
Sbjct: 1010 GEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGI 1069
Query: 113 AVVPEDGLMFWTDWG-EIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVD 171
G ++WTDW + PKIE + M+G R+++V+D++ PNG+T D +S + WVD
Sbjct: 1070 VTDSVRGNLYWTDWNRDNPKIETSYMDG--TNRRILVQDDLGLPNGLTFDAFSSQLCWVD 1127
Query: 172 AKLQFVDVIDFNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIK 231
A + ++ + R++ ++ GL YPFA+T LY+TDW+ S+ D+A + K
Sbjct: 1128 AGTNRAECLNPSQPSRRKALE-GLQYPFAVTSYGKNLYFTDWKMNSVVALDLAIS--KET 1184
Query: 232 ELIKSHPVPADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACP 285
+ + H + Q +Y C NN GC+HLCL +P C CP
Sbjct: 1185 DAFQPHKQTRLYGITTALSQCPQGHNY-CSVNNGGCTHLCLATPG--SRTCRCP 1235
Score = 128 bits (309), Expect = 1e-28
Identities = 75/262 (28%), Positives = 124/262 (47%), Gaps = 9/262 (3%)
Query: 638 KEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEW-LGLVEGLAIDWSGQNIYW 696
K + LA +YW+D +I R S++G I+ LG EG+A+D G+NI+W
Sbjct: 978 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFW 1037
Query: 697 TDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELG--SKSIKRAAMDG 754
TD+ RIEV++LDG+ RR + L P+ IV D +G +YW++ + I+ + MDG
Sbjct: 1038 TDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDG 1097
Query: 755 SSVSVFM-EQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPMPYALA 813
++ + + + +G + L D + W E + R+ + + P+A+
Sbjct: 1098 TNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVT 1157
Query: 814 LFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLD-YISDLKLYHRAKSMGSNQCGVDNG 872
+ ++Y+ DW + + + + + G N C V+NG
Sbjct: 1158 SYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNG 1217
Query: 873 GCSHLCLPTPGDVRTDYRCACP 894
GC+HLCL TPG RT C CP
Sbjct: 1218 GCTHLCLATPGS-RT---CRCP 1235
Score = 58.8 bits (136), Expect = 1e-07
Identities = 29/98 (29%), Positives = 49/98 (50%), Gaps = 2/98 (2%)
Query: 412 KVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIA 471
K +H +A ++W+D E P I RA+L G +I + L P IA
Sbjct: 970 KAFLHVPAKVIIGLAFDCVDKMVYWTDITE--PSIGRASLHGGEPTTIIRQDLGSPEGIA 1027
Query: 472 LDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDIIH 509
+D + ++W D+ +IEV +DGT+R+ L D+++
Sbjct: 1028 VDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVN 1065
Score = 56.4 bits (130), Expect = 6e-07
Identities = 37/145 (25%), Positives = 64/145 (44%), Gaps = 4/145 (2%)
Query: 603 CVEPEAFLVYSRKNIIGRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTI 662
CV+ + + IGR S+ +I +DL +A+ G ++W+DS I
Sbjct: 987 CVDKMVYWTDITEPSIGRASLHGGEPTTIIR-QDLGSPEGIAVDHLGRNIFWTDSNLDRI 1045
Query: 663 NRCSVNGSAVEKIVEW-LGLVEGLAIDWSGQNIYWTD--TTTQRIEVSRLDGSSRRAIIW 719
++G+ + E L G+ D N+YWTD +IE S +DG++RR ++
Sbjct: 1046 EVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQ 1105
Query: 720 QGLKKPKSIVLDPKKGYMYWSELGS 744
L P + D + W + G+
Sbjct: 1106 DDLGLPNGLTFDAFSSQLCWVDAGT 1130
Score = 52.0 bits (119), Expect = 1e-05
Identities = 47/191 (24%), Positives = 76/191 (39%), Gaps = 15/191 (7%)
Query: 909 PEEFLLFAQKNAVGRIMVANGECND----AYIPLTGLKNVRAIEYDPVEKQLYWMDDDSH 964
P LLFAQ + R+ + A++ + K + + +D V+K +YW D
Sbjct: 942 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPA-KVIIGLAFDCVDKMVYWTDITEP 1000
Query: 965 SIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSS 1024
SI R + L P + +D LGR ++WT ++ D I +D +
Sbjct: 1001 SIGRASLH-----GGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLD-GTQ 1054
Query: 1025 TGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRG--AIMRANVDGTGRVELARADNA--TAL 1080
V+ D + PR + + L W D R I + +DGT R L + D L
Sbjct: 1055 RRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGL 1114
Query: 1081 ALDQSAGTVYW 1091
D + + W
Sbjct: 1115 TFDAFSSQLCW 1125
Score = 51.2 bits (117), Expect = 2e-05
Identities = 38/167 (22%), Positives = 71/167 (42%), Gaps = 8/167 (4%)
Query: 326 PYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGV-PDSIAI 384
P T+ +DL + D I+W D I A+LDG+ + V+ + V P I
Sbjct: 1012 PTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVT 1071
Query: 385 DPLSRKIYWTDPVMDT--INVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEK 442
D + +YWTD D I + +DG+ ++++ +L P + + + W D
Sbjct: 1072 DSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTN 1131
Query: 443 KPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKI 489
+ + + + L E L +P A+ + LY+ D + + +
Sbjct: 1132 RAECLNPSQPSRRKAL---EGLQYP--FAVTSYGKNLYFTDWKMNSV 1173
Score = 50.8 bits (116), Expect = 3e-05
Identities = 40/149 (26%), Positives = 64/149 (42%), Gaps = 7/149 (4%)
Query: 68 GIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWG 127
G+A D +YWTD I S+ + ++ IAV +FWTD
Sbjct: 982 GLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTD-S 1040
Query: 128 EIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQ--FVDVIDFNGE 185
+ +IE A ++G R+V+ ++ P GI D +YW D ++ +G
Sbjct: 1041 NLDRIEVAKLDG--TQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGT 1098
Query: 186 KRKRVVKGGLVYPFALTFS--NDKLYWTD 212
R+ +V+ L P LTF + +L W D
Sbjct: 1099 NRRILVQDDLGLPNGLTFDAFSSQLCWVD 1127
Score = 37.5 bits (83), Expect = 0.29
Identities = 32/136 (23%), Positives = 56/136 (41%), Gaps = 8/136 (5%)
Query: 920 AVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXX 979
++GR + GE I L + I D + + ++W D + + R+ ++
Sbjct: 1001 SIGRASLHGGE--PTTIIRQDLGSPEGIAVDHLGRNIFWTDSN---LDRIEVA--KLDGT 1053
Query: 980 XXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINA-TSIDNNSSTGVIVRGDRMLPRH 1038
L P +V D + +YWT +RD+ TS + ++ ++V+ D LP
Sbjct: 1054 QRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNG 1113
Query: 1039 LAFHQTKRYLIWNDVG 1054
L F L W D G
Sbjct: 1114 LTFDAFSSQLCWVDAG 1129
>AL122018-1|CAI22680.1| 1114|Homo sapiens nidogen 1 protein.
Length = 1114
Score = 156 bits (378), Expect = 5e-37
Identities = 83/255 (32%), Positives = 129/255 (50%), Gaps = 9/255 (3%)
Query: 342 FDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSS-GVPDSIAIDPLSRKIYWTDPVMDT 400
FD + +YW D +I +A L G + + ++R G P+ IA+D L R I+WTD +D
Sbjct: 852 FDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDR 911
Query: 401 INVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLI 460
I VA+LDG+ +V+ T+L +PR I G ++W+DWN PKIE + +DG+ R +L+
Sbjct: 912 IEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILV 971
Query: 461 SEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXXXXXX 520
+ L PN + D +++L W DA T++ E N R++ + + F
Sbjct: 972 QDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSYGKNL 1030
Query: 521 XXXXMQKRT---LD-RINKNTGLDRQPVVEQMANMMGVKAFRLGAPLGWNPCADDNGGCS 576
+ + LD I+K T QP + + G+ P G N C+ +NGGC+
Sbjct: 1031 YFTDWKMNSVVALDLAISKETDAF-QP--HKQTRLYGITTALSQCPQGHNYCSVNNGGCT 1087
Query: 577 HLCFNRPDDYICGCP 591
HLC P C CP
Sbjct: 1088 HLCLATPGSRTCRCP 1102
Score = 138 bits (335), Expect = 8e-32
Identities = 78/234 (33%), Positives = 125/234 (53%), Gaps = 9/234 (3%)
Query: 53 GEKFKIVSEGLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAI 112
GE I+ + L +P GIA+D ++WTD ++IEV + R+VLF +++ R I
Sbjct: 877 GEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGI 936
Query: 113 AVVPEDGLMFWTDWG-EIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVD 171
G ++WTDW + PKIE + M+G R+++V+D++ PNG+T D +S + WVD
Sbjct: 937 VTDSVRGNLYWTDWNRDNPKIETSYMDG--TNRRILVQDDLGLPNGLTFDAFSSQLCWVD 994
Query: 172 AKLQFVDVIDFNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIK 231
A + ++ + R++ ++ GL YPFA+T LY+TDW+ S+ D+A + K
Sbjct: 995 AGTNRAECLNPSQPSRRKALE-GLQYPFAVTSYGKNLYFTDWKMNSVVALDLAIS--KET 1051
Query: 232 ELIKSHPVPADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACP 285
+ + H + Q +Y C NN GC+HLCL +P C CP
Sbjct: 1052 DAFQPHKQTRLYGITTALSQCPQGHNY-CSVNNGGCTHLCLATPG--SRTCRCP 1102
Score = 128 bits (309), Expect = 1e-28
Identities = 75/262 (28%), Positives = 124/262 (47%), Gaps = 9/262 (3%)
Query: 638 KEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEW-LGLVEGLAIDWSGQNIYW 696
K + LA +YW+D +I R S++G I+ LG EG+A+D G+NI+W
Sbjct: 845 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFW 904
Query: 697 TDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELG--SKSIKRAAMDG 754
TD+ RIEV++LDG+ RR + L P+ IV D +G +YW++ + I+ + MDG
Sbjct: 905 TDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDG 964
Query: 755 SSVSVFM-EQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPMPYALA 813
++ + + + +G + L D + W E + R+ + + P+A+
Sbjct: 965 TNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVT 1024
Query: 814 LFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLD-YISDLKLYHRAKSMGSNQCGVDNG 872
+ ++Y+ DW + + + + + G N C V+NG
Sbjct: 1025 SYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNG 1084
Query: 873 GCSHLCLPTPGDVRTDYRCACP 894
GC+HLCL TPG RT C CP
Sbjct: 1085 GCTHLCLATPGS-RT---CRCP 1102
Score = 58.8 bits (136), Expect = 1e-07
Identities = 29/98 (29%), Positives = 49/98 (50%), Gaps = 2/98 (2%)
Query: 412 KVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIA 471
K +H +A ++W+D E P I RA+L G +I + L P IA
Sbjct: 837 KAFLHVPAKVIIGLAFDCVDKMVYWTDITE--PSIGRASLHGGEPTTIIRQDLGSPEGIA 894
Query: 472 LDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDIIH 509
+D + ++W D+ +IEV +DGT+R+ L D+++
Sbjct: 895 VDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVN 932
Score = 56.4 bits (130), Expect = 6e-07
Identities = 37/145 (25%), Positives = 64/145 (44%), Gaps = 4/145 (2%)
Query: 603 CVEPEAFLVYSRKNIIGRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTI 662
CV+ + + IGR S+ +I +DL +A+ G ++W+DS I
Sbjct: 854 CVDKMVYWTDITEPSIGRASLHGGEPTTIIR-QDLGSPEGIAVDHLGRNIFWTDSNLDRI 912
Query: 663 NRCSVNGSAVEKIVEW-LGLVEGLAIDWSGQNIYWTD--TTTQRIEVSRLDGSSRRAIIW 719
++G+ + E L G+ D N+YWTD +IE S +DG++RR ++
Sbjct: 913 EVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQ 972
Query: 720 QGLKKPKSIVLDPKKGYMYWSELGS 744
L P + D + W + G+
Sbjct: 973 DDLGLPNGLTFDAFSSQLCWVDAGT 997
Score = 52.0 bits (119), Expect = 1e-05
Identities = 47/191 (24%), Positives = 76/191 (39%), Gaps = 15/191 (7%)
Query: 909 PEEFLLFAQKNAVGRIMVANGECND----AYIPLTGLKNVRAIEYDPVEKQLYWMDDDSH 964
P LLFAQ + R+ + A++ + K + + +D V+K +YW D
Sbjct: 809 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPA-KVIIGLAFDCVDKMVYWTDITEP 867
Query: 965 SIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSS 1024
SI R + L P + +D LGR ++WT ++ D I +D +
Sbjct: 868 SIGRASLH-----GGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLD-GTQ 921
Query: 1025 TGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRG--AIMRANVDGTGRVELARADNA--TAL 1080
V+ D + PR + + L W D R I + +DGT R L + D L
Sbjct: 922 RRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGL 981
Query: 1081 ALDQSAGTVYW 1091
D + + W
Sbjct: 982 TFDAFSSQLCW 992
Score = 51.2 bits (117), Expect = 2e-05
Identities = 38/167 (22%), Positives = 71/167 (42%), Gaps = 8/167 (4%)
Query: 326 PYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGV-PDSIAI 384
P T+ +DL + D I+W D I A+LDG+ + V+ + V P I
Sbjct: 879 PTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVT 938
Query: 385 DPLSRKIYWTDPVMDT--INVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEK 442
D + +YWTD D I + +DG+ ++++ +L P + + + W D
Sbjct: 939 DSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTN 998
Query: 443 KPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKI 489
+ + + + L E L +P A+ + LY+ D + + +
Sbjct: 999 RAECLNPSQPSRRKAL---EGLQYP--FAVTSYGKNLYFTDWKMNSV 1040
Score = 50.8 bits (116), Expect = 3e-05
Identities = 40/149 (26%), Positives = 64/149 (42%), Gaps = 7/149 (4%)
Query: 68 GIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWG 127
G+A D +YWTD I S+ + ++ IAV +FWTD
Sbjct: 849 GLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTD-S 907
Query: 128 EIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQ--FVDVIDFNGE 185
+ +IE A ++G R+V+ ++ P GI D +YW D ++ +G
Sbjct: 908 NLDRIEVAKLDG--TQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGT 965
Query: 186 KRKRVVKGGLVYPFALTFS--NDKLYWTD 212
R+ +V+ L P LTF + +L W D
Sbjct: 966 NRRILVQDDLGLPNGLTFDAFSSQLCWVD 994
Score = 37.5 bits (83), Expect = 0.29
Identities = 32/136 (23%), Positives = 56/136 (41%), Gaps = 8/136 (5%)
Query: 920 AVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXX 979
++GR + GE I L + I D + + ++W D + + R+ ++
Sbjct: 868 SIGRASLHGGE--PTTIIRQDLGSPEGIAVDHLGRNIFWTDSN---LDRIEVA--KLDGT 920
Query: 980 XXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINA-TSIDNNSSTGVIVRGDRMLPRH 1038
L P +V D + +YWT +RD+ TS + ++ ++V+ D LP
Sbjct: 921 QRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNG 980
Query: 1039 LAFHQTKRYLIWNDVG 1054
L F L W D G
Sbjct: 981 LTFDAFSSQLCWVDAG 996
>X82245-1|CAA57709.1| 1246|Homo sapiens nidogen protein.
Length = 1246
Score = 155 bits (376), Expect = 9e-37
Identities = 83/255 (32%), Positives = 129/255 (50%), Gaps = 9/255 (3%)
Query: 342 FDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSS-GVPDSIAIDPLSRKIYWTDPVMDT 400
FD + +YW D +I +A L G + + ++R G P+ IA+D L R I+WTD +D
Sbjct: 984 FDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDR 1043
Query: 401 INVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLI 460
I VA+LDG+ +V+ T+L +PR I G ++W+DWN PKIE + +DG+ R +L+
Sbjct: 1044 IEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILV 1103
Query: 461 SEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXXXXXX 520
+ L PN + D +++L W DA T++ E N R++ + + F
Sbjct: 1104 QDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSYGKNL 1162
Query: 521 XXXXMQKRT---LD-RINKNTGLDRQPVVEQMANMMGVKAFRLGAPLGWNPCADDNGGCS 576
+ + LD I+K T QP + + G+ P G N C+ +NGGC+
Sbjct: 1163 YFTDWKMNSVVALDLAISKETDAF-QP--HKQTRLYGITTALSQCPQGHNYCSVNNGGCT 1219
Query: 577 HLCFNRPDDYICGCP 591
HLC P C CP
Sbjct: 1220 HLCLATPGSRTCRCP 1234
Score = 136 bits (328), Expect = 6e-31
Identities = 77/234 (32%), Positives = 124/234 (52%), Gaps = 9/234 (3%)
Query: 53 GEKFKIVSEGLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAI 112
GE I+ + L +P GIA+D ++WTD ++IEV + R+VLF +++ R I
Sbjct: 1009 GEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGI 1068
Query: 113 AVVPEDGLMFWTDWG-EIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVD 171
G ++WTDW + PKIE + M+G R+++V+D++ PNG+ D +S + WVD
Sbjct: 1069 VTDSVRGNLYWTDWNRDNPKIETSYMDG--TNRRILVQDDLGLPNGLHFDAFSSQLCWVD 1126
Query: 172 AKLQFVDVIDFNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIK 231
A + ++ + R++ ++ GL YPFA+T LY+TDW+ S+ D+A + K
Sbjct: 1127 AGTNRAECLNPSQPSRRKALE-GLQYPFAVTSYGKNLYFTDWKMNSVVALDLAIS--KET 1183
Query: 232 ELIKSHPVPADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACP 285
+ + H + Q +Y C NN GC+HLCL +P C CP
Sbjct: 1184 DAFQPHKQTRLYGITTALSQCPQGHNY-CSVNNGGCTHLCLATPG--SRTCRCP 1234
Score = 127 bits (307), Expect = 2e-28
Identities = 75/262 (28%), Positives = 124/262 (47%), Gaps = 9/262 (3%)
Query: 638 KEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEW-LGLVEGLAIDWSGQNIYW 696
K + LA +YW+D +I R S++G I+ LG EG+A+D G+NI+W
Sbjct: 977 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFW 1036
Query: 697 TDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELG--SKSIKRAAMDG 754
TD+ RIEV++LDG+ RR + L P+ IV D +G +YW++ + I+ + MDG
Sbjct: 1037 TDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDG 1096
Query: 755 SSVSVFM-EQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPMPYALA 813
++ + + + +G + L D + W E + R+ + + P+A+
Sbjct: 1097 TNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVT 1156
Query: 814 LFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLD-YISDLKLYHRAKSMGSNQCGVDNG 872
+ ++Y+ DW + + + + + G N C V+NG
Sbjct: 1157 SYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNG 1216
Query: 873 GCSHLCLPTPGDVRTDYRCACP 894
GC+HLCL TPG RT C CP
Sbjct: 1217 GCTHLCLATPGS-RT---CRCP 1234
Score = 58.8 bits (136), Expect = 1e-07
Identities = 29/98 (29%), Positives = 49/98 (50%), Gaps = 2/98 (2%)
Query: 412 KVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIA 471
K +H +A ++W+D E P I RA+L G +I + L P IA
Sbjct: 969 KAFLHVPAKVIIGLAFDCVDKMVYWTDITE--PSIGRASLHGGEPTTIIRQDLGSPEGIA 1026
Query: 472 LDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDIIH 509
+D + ++W D+ +IEV +DGT+R+ L D+++
Sbjct: 1027 VDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVN 1064
Score = 55.2 bits (127), Expect = 1e-06
Identities = 37/145 (25%), Positives = 64/145 (44%), Gaps = 4/145 (2%)
Query: 603 CVEPEAFLVYSRKNIIGRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTI 662
CV+ + + IGR S+ +I +DL +A+ G ++W+DS I
Sbjct: 986 CVDKMVYWTDITEPSIGRASLHGGEPTTIIR-QDLGSPEGIAVDHLGRNIFWTDSNLDRI 1044
Query: 663 NRCSVNGSAVEKIVEW-LGLVEGLAIDWSGQNIYWTD--TTTQRIEVSRLDGSSRRAIIW 719
++G+ + E L G+ D N+YWTD +IE S +DG++RR ++
Sbjct: 1045 EVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQ 1104
Query: 720 QGLKKPKSIVLDPKKGYMYWSELGS 744
L P + D + W + G+
Sbjct: 1105 DDLGLPNGLHFDAFSSQLCWVDAGT 1129
Score = 51.6 bits (118), Expect = 2e-05
Identities = 44/173 (25%), Positives = 71/173 (41%), Gaps = 13/173 (7%)
Query: 909 PEEFLLFAQKNAVGRIMVANGECND----AYIPLTGLKNVRAIEYDPVEKQLYWMDDDSH 964
P LLFAQ + R+ + A++ + K + + +D V+K +YW D
Sbjct: 941 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPA-KVIIGLAFDCVDKMVYWTDITEP 999
Query: 965 SIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSS 1024
SI R + L P + +D LGR ++WT ++ D I +D +
Sbjct: 1000 SIGRASLH-----GGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLD-GTQ 1053
Query: 1025 TGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRG--AIMRANVDGTGRVELARAD 1075
V+ D + PR + + L W D R I + +DGT R L + D
Sbjct: 1054 RRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDD 1106
Score = 50.4 bits (115), Expect = 4e-05
Identities = 38/167 (22%), Positives = 71/167 (42%), Gaps = 8/167 (4%)
Query: 326 PYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGV-PDSIAI 384
P T+ +DL + D I+W D I A+LDG+ + V+ + V P I
Sbjct: 1011 PTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVT 1070
Query: 385 DPLSRKIYWTDPVMDT--INVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEK 442
D + +YWTD D I + +DG+ ++++ +L P + + + W D
Sbjct: 1071 DSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTN 1130
Query: 443 KPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKI 489
+ + + + L E L +P A+ + LY+ D + + +
Sbjct: 1131 RAECLNPSQPSRRKAL---EGLQYP--FAVTSYGKNLYFTDWKMNSV 1172
Score = 48.0 bits (109), Expect = 2e-04
Identities = 39/149 (26%), Positives = 63/149 (42%), Gaps = 7/149 (4%)
Query: 68 GIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWG 127
G+A D +YWTD I S+ + ++ IAV +FWTD
Sbjct: 981 GLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTD-S 1039
Query: 128 EIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQ--FVDVIDFNGE 185
+ +IE A ++G R+V+ ++ P GI D +YW D ++ +G
Sbjct: 1040 NLDRIEVAKLDG--TQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGT 1097
Query: 186 KRKRVVKGGLVYPFALTFS--NDKLYWTD 212
R+ +V+ L P L F + +L W D
Sbjct: 1098 NRRILVQDDLGLPNGLHFDAFSSQLCWVD 1126
Score = 36.7 bits (81), Expect = 0.50
Identities = 32/136 (23%), Positives = 56/136 (41%), Gaps = 8/136 (5%)
Query: 920 AVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXX 979
++GR + GE I L + I D + + ++W D + + R+ ++
Sbjct: 1000 SIGRASLHGGE--PTTIIRQDLGSPEGIAVDHLGRNIFWTDSN---LDRIEVA--KLDGT 1052
Query: 980 XXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINA-TSIDNNSSTGVIVRGDRMLPRH 1038
L P +V D + +YWT +RD+ TS + ++ ++V+ D LP
Sbjct: 1053 QRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNG 1112
Query: 1039 LAFHQTKRYLIWNDVG 1054
L F L W D G
Sbjct: 1113 LHFDAFSSQLCWVDAG 1128
>M30269-1|AAA59932.1| 1247|Homo sapiens nidogen protein.
Length = 1247
Score = 155 bits (376), Expect = 9e-37
Identities = 83/255 (32%), Positives = 129/255 (50%), Gaps = 9/255 (3%)
Query: 342 FDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSS-GVPDSIAIDPLSRKIYWTDPVMDT 400
FD + +YW D +I +A L G + + ++R G P+ IA+D L R I+WTD +D
Sbjct: 985 FDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDR 1044
Query: 401 INVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLI 460
I VA+LDG+ +V+ T+L +PR I G ++W+DWN PKIE + +DG+ R +L+
Sbjct: 1045 IEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILV 1104
Query: 461 SEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXXXXXX 520
+ L PN + D +++L W DA T++ E N R++ + + F
Sbjct: 1105 QDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSYGKNL 1163
Query: 521 XXXXMQKRT---LD-RINKNTGLDRQPVVEQMANMMGVKAFRLGAPLGWNPCADDNGGCS 576
+ + LD I+K T QP + + G+ P G N C+ +NGGC+
Sbjct: 1164 YFTDWKMNSVVALDLAISKETDAF-QP--HKQTRLYGITTALSQCPQGHNYCSVNNGGCT 1220
Query: 577 HLCFNRPDDYICGCP 591
HLC P C CP
Sbjct: 1221 HLCLATPGSRTCRCP 1235
Score = 136 bits (328), Expect = 6e-31
Identities = 77/234 (32%), Positives = 124/234 (52%), Gaps = 9/234 (3%)
Query: 53 GEKFKIVSEGLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAI 112
GE I+ + L +P GIA+D ++WTD ++IEV + R+VLF +++ R I
Sbjct: 1010 GEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGI 1069
Query: 113 AVVPEDGLMFWTDWG-EIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVD 171
G ++WTDW + PKIE + M+G R+++V+D++ PNG+ D +S + WVD
Sbjct: 1070 VTDSVRGNLYWTDWNRDNPKIETSYMDG--TNRRILVQDDLGLPNGLHFDAFSSQLCWVD 1127
Query: 172 AKLQFVDVIDFNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIK 231
A + ++ + R++ ++ GL YPFA+T LY+TDW+ S+ D+A + K
Sbjct: 1128 AGTNRAECLNPSQPSRRKALE-GLQYPFAVTSYGKNLYFTDWKMNSVVALDLAIS--KET 1184
Query: 232 ELIKSHPVPADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACP 285
+ + H + Q +Y C NN GC+HLCL +P C CP
Sbjct: 1185 DAFQPHKQTRLYGITTALSQCPQGHNY-CSVNNGGCTHLCLATPG--SRTCRCP 1235
Score = 127 bits (307), Expect = 2e-28
Identities = 75/262 (28%), Positives = 124/262 (47%), Gaps = 9/262 (3%)
Query: 638 KEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEW-LGLVEGLAIDWSGQNIYW 696
K + LA +YW+D +I R S++G I+ LG EG+A+D G+NI+W
Sbjct: 978 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFW 1037
Query: 697 TDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELG--SKSIKRAAMDG 754
TD+ RIEV++LDG+ RR + L P+ IV D +G +YW++ + I+ + MDG
Sbjct: 1038 TDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDG 1097
Query: 755 SSVSVFM-EQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPMPYALA 813
++ + + + +G + L D + W E + R+ + + P+A+
Sbjct: 1098 TNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVT 1157
Query: 814 LFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLD-YISDLKLYHRAKSMGSNQCGVDNG 872
+ ++Y+ DW + + + + + G N C V+NG
Sbjct: 1158 SYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNG 1217
Query: 873 GCSHLCLPTPGDVRTDYRCACP 894
GC+HLCL TPG RT C CP
Sbjct: 1218 GCTHLCLATPGS-RT---CRCP 1235
Score = 58.8 bits (136), Expect = 1e-07
Identities = 29/98 (29%), Positives = 49/98 (50%), Gaps = 2/98 (2%)
Query: 412 KVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIA 471
K +H +A ++W+D E P I RA+L G +I + L P IA
Sbjct: 970 KAFLHVPAKVIIGLAFDCVDKMVYWTDITE--PSIGRASLHGGEPTTIIRQDLGSPEGIA 1027
Query: 472 LDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDIIH 509
+D + ++W D+ +IEV +DGT+R+ L D+++
Sbjct: 1028 VDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVN 1065
Score = 55.2 bits (127), Expect = 1e-06
Identities = 37/145 (25%), Positives = 64/145 (44%), Gaps = 4/145 (2%)
Query: 603 CVEPEAFLVYSRKNIIGRLSIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTI 662
CV+ + + IGR S+ +I +DL +A+ G ++W+DS I
Sbjct: 987 CVDKMVYWTDITEPSIGRASLHGGEPTTIIR-QDLGSPEGIAVDHLGRNIFWTDSNLDRI 1045
Query: 663 NRCSVNGSAVEKIVEW-LGLVEGLAIDWSGQNIYWTD--TTTQRIEVSRLDGSSRRAIIW 719
++G+ + E L G+ D N+YWTD +IE S +DG++RR ++
Sbjct: 1046 EVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQ 1105
Query: 720 QGLKKPKSIVLDPKKGYMYWSELGS 744
L P + D + W + G+
Sbjct: 1106 DDLGLPNGLHFDAFSSQLCWVDAGT 1130
Score = 51.6 bits (118), Expect = 2e-05
Identities = 44/173 (25%), Positives = 71/173 (41%), Gaps = 13/173 (7%)
Query: 909 PEEFLLFAQKNAVGRIMVANGECND----AYIPLTGLKNVRAIEYDPVEKQLYWMDDDSH 964
P LLFAQ + R+ + A++ + K + + +D V+K +YW D
Sbjct: 942 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPA-KVIIGLAFDCVDKMVYWTDITEP 1000
Query: 965 SIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSS 1024
SI R + L P + +D LGR ++WT ++ D I +D +
Sbjct: 1001 SIGRASLH-----GGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLD-GTQ 1054
Query: 1025 TGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRG--AIMRANVDGTGRVELARAD 1075
V+ D + PR + + L W D R I + +DGT R L + D
Sbjct: 1055 RRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDD 1107
Score = 50.4 bits (115), Expect = 4e-05
Identities = 38/167 (22%), Positives = 71/167 (42%), Gaps = 8/167 (4%)
Query: 326 PYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGV-PDSIAI 384
P T+ +DL + D I+W D I A+LDG+ + V+ + V P I
Sbjct: 1012 PTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVT 1071
Query: 385 DPLSRKIYWTDPVMDT--INVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEK 442
D + +YWTD D I + +DG+ ++++ +L P + + + W D
Sbjct: 1072 DSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTN 1131
Query: 443 KPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKI 489
+ + + + L E L +P A+ + LY+ D + + +
Sbjct: 1132 RAECLNPSQPSRRKAL---EGLQYP--FAVTSYGKNLYFTDWKMNSV 1173
Score = 48.0 bits (109), Expect = 2e-04
Identities = 39/149 (26%), Positives = 63/149 (42%), Gaps = 7/149 (4%)
Query: 68 GIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWG 127
G+A D +YWTD I S+ + ++ IAV +FWTD
Sbjct: 982 GLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTD-S 1040
Query: 128 EIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQ--FVDVIDFNGE 185
+ +IE A ++G R+V+ ++ P GI D +YW D ++ +G
Sbjct: 1041 NLDRIEVAKLDG--TQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGT 1098
Query: 186 KRKRVVKGGLVYPFALTFS--NDKLYWTD 212
R+ +V+ L P L F + +L W D
Sbjct: 1099 NRRILVQDDLGLPNGLHFDAFSSQLCWVD 1127
Score = 36.7 bits (81), Expect = 0.50
Identities = 32/136 (23%), Positives = 56/136 (41%), Gaps = 8/136 (5%)
Query: 920 AVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXX 979
++GR + GE I L + I D + + ++W D + + R+ ++
Sbjct: 1001 SIGRASLHGGE--PTTIIRQDLGSPEGIAVDHLGRNIFWTDSN---LDRIEVA--KLDGT 1053
Query: 980 XXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINA-TSIDNNSSTGVIVRGDRMLPRH 1038
L P +V D + +YWT +RD+ TS + ++ ++V+ D LP
Sbjct: 1054 QRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNG 1113
Query: 1039 LAFHQTKRYLIWNDVG 1054
L F L W D G
Sbjct: 1114 LHFDAFSSQLCWVDAG 1129
>BC139736-1|AAI39737.1| 224|Homo sapiens LRP5L protein protein.
Length = 224
Score = 155 bits (376), Expect = 9e-37
Identities = 76/218 (34%), Positives = 124/218 (56%), Gaps = 3/218 (1%)
Query: 348 YIYWADGLAKTISKARLDGSDQSVVVRSS-GVPDSIAIDPLSRKIYWTDPVMDTINVARL 406
++YW D I +A LDGS ++ + PD IA++ ++R +YWT + I V L
Sbjct: 4 HVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCL 63
Query: 407 DGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTW 466
+ + K+++ ++ +PRAIALH G +W DW E P+I+RANLD +L++ L W
Sbjct: 64 NSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGEN-PEIKRANLDRQELRVLVNASLGW 122
Query: 467 PNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXXXXXXXXXXMQ 526
PN +ALD KLYWGDA+T KIE ++D T+R+ L + + HIF Q
Sbjct: 123 PNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQ 182
Query: 527 KRTLDRINKNTGLDRQPVVEQMANMMGVKAFRLGAPLG 564
++ R++K +R +++Q+ ++MG+KA + +G
Sbjct: 183 HHSIKRVHK-VKANRDVIIDQLPDLMGLKAVNVDKVVG 219
Score = 127 bits (306), Expect = 3e-28
Identities = 61/161 (37%), Positives = 91/161 (56%), Gaps = 2/161 (1%)
Query: 58 IVSEGLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPE 117
+++ + P IA++W LYWT T IEV + K+L ++D RAIA+ PE
Sbjct: 28 LINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLNSTSHKILVSEDMDEPRAIALHPE 87
Query: 118 DGLMFWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFV 177
GL +W DWGE P+I+RA N D +V+V ++ WPNG+ +D +YW DAK +
Sbjct: 88 MGLTYWIDWGENPEIKRA--NLDRQELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKI 145
Query: 178 DVIDFNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSI 218
+ I + KR+ ++K L + F T D +YWT WQ+ SI
Sbjct: 146 EAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQHHSI 186
Score = 115 bits (277), Expect = 9e-25
Identities = 62/216 (28%), Positives = 113/216 (52%), Gaps = 5/216 (2%)
Query: 652 LYWSDSKTKTINRCSVNGSAVEKIVEW-LGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLD 710
+YW+D + I R ++GS + ++ + + +A++W +++YWT T T+ IEV+ L+
Sbjct: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
Query: 711 GSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELG-SKSIKRAAMDGSSVSVFME-QVGRVH 768
+S + ++ + + +P++I L P+ G YW + G + IKRA +D + V + +G +
Sbjct: 65 STSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPN 124
Query: 769 ALAIDYERRAIYWAALDPPVVEFAFLNGTGRQT-LADNIPMPYALALFNDSVYWGDWNTG 827
LA+D + +YW +E ++ T RQT L D +P + L D +YW W
Sbjct: 125 GLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQHH 184
Query: 828 QIQQARKTDGSNRKSIRKDLDYISDLKLYHRAKSMG 863
I++ K +NR I L + LK + K +G
Sbjct: 185 SIKRVHKVK-ANRDVIIDQLPDLMGLKAVNVDKVVG 219
Score = 61.3 bits (142), Expect = 2e-08
Identities = 42/159 (26%), Positives = 76/159 (47%), Gaps = 6/159 (3%)
Query: 693 NIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKSIKRAAM 752
++YWTD I + LDGS + +I + P I ++ +YW+ G++ I+ +
Sbjct: 4 HVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCL 63
Query: 753 DGSSVSVFM-EQVGRVHALAIDYERRAIYWAAL-DPPVVEFAFLNGTGRQTLAD---NIP 807
+ +S + + E + A+A+ E YW + P ++ A L+ + L + P
Sbjct: 64 NSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWP 123
Query: 808 MPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKD 846
AL L +YWGD T +I +A D + R+++ KD
Sbjct: 124 NGLALDLQEGKLYWGDAKTDKI-EAISVDETKRQTLLKD 161
Score = 56.0 bits (129), Expect = 8e-07
Identities = 43/146 (29%), Positives = 66/146 (45%), Gaps = 15/146 (10%)
Query: 952 VEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADR 1011
+E +YW DD+ +IRR + ++ P + ++ + R++YWT
Sbjct: 1 MEGHVYWTDDEVWAIRRAYLD-----GSGAQTLINTKINDPDDIAVNWVARSLYWTHTGT 55
Query: 1012 DSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRG-AIMRANVDGTGRVE 1070
+ I T + N++S ++V D PR +A H W D G I RAN+D R E
Sbjct: 56 EHIEVTCL-NSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLD---RQE 111
Query: 1071 LARADNAT-----ALALDQSAGTVYW 1091
L NA+ LALD G +YW
Sbjct: 112 LRVLVNASLGWPNGLALDLQEGKLYW 137
Score = 51.2 bits (117), Expect = 2e-05
Identities = 32/127 (25%), Positives = 63/127 (49%), Gaps = 5/127 (3%)
Query: 734 KGYMYWSELGSKSIKRAAMDGSSVSVFME-QVGRVHALAIDYERRAIYWAALDPPVVEFA 792
+G++YW++ +I+RA +DGS + ++ +A+++ R++YW +E
Sbjct: 2 EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61
Query: 793 FLNGTGRQTL-ADNIPMPYALALFNDS--VYWGDWNTG-QIQQARKTDGSNRKSIRKDLD 848
LN T + L ++++ P A+AL + YW DW +I++A R + L
Sbjct: 62 CLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLG 121
Query: 849 YISDLKL 855
+ + L L
Sbjct: 122 WPNGLAL 128
>D86425-1|BAA13087.1| 1376|Homo sapiens osteonidogen protein.
Length = 1376
Score = 153 bits (370), Expect = 5e-36
Identities = 79/228 (34%), Positives = 129/228 (56%), Gaps = 4/228 (1%)
Query: 340 VDFDPKTEYIYWADGLAKTISKARLD-GSDQSVVVRSSGV-PDSIAIDPLSRKIYWTDPV 397
+D+D + +YW D +TIS+A L+ G++ +V S + P+ +AID + R +YWTD V
Sbjct: 1148 IDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSV 1207
Query: 398 MDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRV 457
+D I A LDGS KV+ +T+L +PRAIA+ G ++W+DWN + PKIE ++LDG R
Sbjct: 1208 LDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRR 1267
Query: 458 LLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXXX 517
+LI+ + PN + D + L W DA T K+E DGT R+ + N++ + F
Sbjct: 1268 ILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVI-QNNLKYPFSIVSYA 1326
Query: 518 XXXXXXXMQKRTLDRINKNTG-LDRQPVVEQMANMMGVKAFRLGAPLG 564
++ + +NK++G + + EQ +++ G+ A P G
Sbjct: 1327 DHFYHTDWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITAVYPYCPTG 1374
Score = 125 bits (302), Expect = 8e-28
Identities = 68/193 (35%), Positives = 108/193 (55%), Gaps = 6/193 (3%)
Query: 23 VDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAIDWYTDKLYWTD 82
+D+ R+ ++ W+D I E IV+ GL++P G+AID +YWTD
Sbjct: 1148 IDYDCRERMVYWTDVAGRTISRAGLE--LGAEPETIVNSGLISPEGLAIDHIRRTMYWTD 1205
Query: 83 GETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWG-EIPKIERAGMNGDP 141
+KIE + RKVLF++++ RAIAV P G ++WTDW E PKIE + ++G+
Sbjct: 1206 SVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGE- 1264
Query: 142 ATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVKGGLVYPFAL 201
R++++ +I PNG+T D + L+ W DA + ++ +G R RV++ L YPF++
Sbjct: 1265 -NRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGR-RVIQNNLKYPFSI 1322
Query: 202 TFSNDKLYWTDWQ 214
D Y TDW+
Sbjct: 1323 VSYADHFYHTDWR 1335
Score = 111 bits (266), Expect = 2e-23
Identities = 55/191 (28%), Positives = 102/191 (53%), Gaps = 5/191 (2%)
Query: 652 LYWSDSKTKTINRCSVNGSAVEKIVEWLGLV--EGLAIDWSGQNIYWTDTTTQRIEVSRL 709
+YW+D +TI+R + A + + GL+ EGLAID + +YWTD+ +IE + L
Sbjct: 1157 VYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALL 1216
Query: 710 DGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS--IKRAAMDGSSVSVFME-QVGR 766
DGS R+ + + L P++I +DP +G +YW++ ++ I+ +++DG + + + +G
Sbjct: 1217 DGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGL 1276
Query: 767 VHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPMPYALALFNDSVYWGDWNT 826
+ L D + + WA +E +GTGR+ + +N+ P+++ + D Y DW
Sbjct: 1277 PNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFSIVSYADHFYHTDWRR 1336
Query: 827 GQIQQARKTDG 837
+ K G
Sbjct: 1337 DGVVSVNKHSG 1347
Score = 73.7 bits (173), Expect = 4e-12
Identities = 49/176 (27%), Positives = 88/176 (50%), Gaps = 8/176 (4%)
Query: 681 LVEGLAIDWSGQNIYWTDTTTQRIEVSRLD-GSSRRAIIWQGLKKPKSIVLDPKKGYMYW 739
++ G+ D + +YWTD + I + L+ G+ I+ GL P+ + +D + MYW
Sbjct: 1144 IIVGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYW 1203
Query: 740 SELGSKSIKRAAMDGSSVSV-FMEQVGRVHALAIDYERRAIYWA--ALDPPVVEFAFLNG 796
++ I+ A +DGS V F + A+A+D R +YW + P +E + L+G
Sbjct: 1204 TDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDG 1263
Query: 797 TGRQTLAD-NIPMPYALAL--FNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDY 849
R+ L + +I +P L F+ + W D T ++ + DG+ R+ I+ +L Y
Sbjct: 1264 ENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKL-ECTLPDGTGRRVIQNNLKY 1318
Score = 58.8 bits (136), Expect = 1e-07
Identities = 53/199 (26%), Positives = 81/199 (40%), Gaps = 12/199 (6%)
Query: 901 KDNITCSEPEEFLLFAQKNAVGRIMVANGECN-DAYIPLTGLKN--VRAIEYDPVEKQLY 957
+ ++T FLL+ Q +G + + DA L L + I+YD E+ +Y
Sbjct: 1099 RPDVTPPSVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVY 1158
Query: 958 WMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINAT 1017
W D +I R + GL P + +D + RTMYWT + D I +
Sbjct: 1159 WTDVAGRTISRAGLELGAEPETIVNS----GLISPEGLAIDHIRRTMYWTDSVLDKIESA 1214
Query: 1018 SIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGA--IMRANVDGTGRVELARAD 1075
+D S V+ D + PR +A + L W D R A I +++DG R L D
Sbjct: 1215 LLD-GSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTD 1273
Query: 1076 NA--TALALDQSAGTVYWA 1092
L D + + WA
Sbjct: 1274 IGLPNGLTFDPFSKLLCWA 1292
Score = 44.0 bits (99), Expect = 0.003
Identities = 31/132 (23%), Positives = 53/132 (40%), Gaps = 8/132 (6%)
Query: 939 TGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLD 998
+GL + + D + + +YW D I + L P + +D
Sbjct: 1184 SGLISPEGLAIDHIRRTMYWTDSVLDKIESALLD-----GSERKVLFYTDLVNPRAIAVD 1238
Query: 999 VLGRTMYWTCADRDS--INATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRG 1056
+ +YWT +R++ I +S+D + +++ D LP L F + L W D G
Sbjct: 1239 PIRGNLYWTDWNREAPKIETSSLDGENRR-ILINTDIGLPNGLTFDPFSKLLCWADAGTK 1297
Query: 1057 AIMRANVDGTGR 1068
+ DGTGR
Sbjct: 1298 KLECTLPDGTGR 1309
Score = 33.5 bits (73), Expect = 4.7
Identities = 15/41 (36%), Positives = 19/41 (46%), Gaps = 2/41 (4%)
Query: 566 NPCADDNGGC--SHLCFNRPDDYICGCPLGLELTADKKTCV 604
N CA C + +C N P Y C C G E D+ TC+
Sbjct: 804 NECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCI 844
>BC035608-1|AAH35608.1| 969|Homo sapiens NID2 protein protein.
Length = 969
Score = 153 bits (370), Expect = 5e-36
Identities = 79/228 (34%), Positives = 129/228 (56%), Gaps = 4/228 (1%)
Query: 340 VDFDPKTEYIYWADGLAKTISKARLD-GSDQSVVVRSSGV-PDSIAIDPLSRKIYWTDPV 397
+D+D + +YW D +TIS+A L+ G++ +V S + P+ +AID + R +YWTD V
Sbjct: 741 IDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSV 800
Query: 398 MDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRV 457
+D I A LDGS KV+ +T+L +PRAIA+ G ++W+DWN + PKIE ++LDG R
Sbjct: 801 LDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRR 860
Query: 458 LLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXXX 517
+LI+ + PN + D + L W DA T K+E DGT R+ + N++ + F
Sbjct: 861 ILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVI-QNNLKYPFSIVSYA 919
Query: 518 XXXXXXXMQKRTLDRINKNTG-LDRQPVVEQMANMMGVKAFRLGAPLG 564
++ + +NK++G + + EQ +++ G+ A P G
Sbjct: 920 DHFYHTDWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITAVYPYCPTG 967
Score = 125 bits (302), Expect = 8e-28
Identities = 68/193 (35%), Positives = 108/193 (55%), Gaps = 6/193 (3%)
Query: 23 VDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAIDWYTDKLYWTD 82
+D+ R+ ++ W+D I E IV+ GL++P G+AID +YWTD
Sbjct: 741 IDYDCRERMVYWTDVAGRTISRAGLE--LGAEPETIVNSGLISPEGLAIDHIRRTMYWTD 798
Query: 83 GETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWG-EIPKIERAGMNGDP 141
+KIE + RKVLF++++ RAIAV P G ++WTDW E PKIE + ++G+
Sbjct: 799 SVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGE- 857
Query: 142 ATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVKGGLVYPFAL 201
R++++ +I PNG+T D + L+ W DA + ++ +G R RV++ L YPF++
Sbjct: 858 -NRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGR-RVIQNNLKYPFSI 915
Query: 202 TFSNDKLYWTDWQ 214
D Y TDW+
Sbjct: 916 VSYADHFYHTDWR 928
Score = 111 bits (266), Expect = 2e-23
Identities = 55/191 (28%), Positives = 102/191 (53%), Gaps = 5/191 (2%)
Query: 652 LYWSDSKTKTINRCSVNGSAVEKIVEWLGLV--EGLAIDWSGQNIYWTDTTTQRIEVSRL 709
+YW+D +TI+R + A + + GL+ EGLAID + +YWTD+ +IE + L
Sbjct: 750 VYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALL 809
Query: 710 DGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS--IKRAAMDGSSVSVFME-QVGR 766
DGS R+ + + L P++I +DP +G +YW++ ++ I+ +++DG + + + +G
Sbjct: 810 DGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGL 869
Query: 767 VHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPMPYALALFNDSVYWGDWNT 826
+ L D + + WA +E +GTGR+ + +N+ P+++ + D Y DW
Sbjct: 870 PNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFSIVSYADHFYHTDWRR 929
Query: 827 GQIQQARKTDG 837
+ K G
Sbjct: 930 DGVVSVNKHSG 940
Score = 73.7 bits (173), Expect = 4e-12
Identities = 49/176 (27%), Positives = 88/176 (50%), Gaps = 8/176 (4%)
Query: 681 LVEGLAIDWSGQNIYWTDTTTQRIEVSRLD-GSSRRAIIWQGLKKPKSIVLDPKKGYMYW 739
++ G+ D + +YWTD + I + L+ G+ I+ GL P+ + +D + MYW
Sbjct: 737 IIVGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYW 796
Query: 740 SELGSKSIKRAAMDGSSVSV-FMEQVGRVHALAIDYERRAIYWA--ALDPPVVEFAFLNG 796
++ I+ A +DGS V F + A+A+D R +YW + P +E + L+G
Sbjct: 797 TDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDG 856
Query: 797 TGRQTLAD-NIPMPYALAL--FNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDY 849
R+ L + +I +P L F+ + W D T ++ + DG+ R+ I+ +L Y
Sbjct: 857 ENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKL-ECTLPDGTGRRVIQNNLKY 911
Score = 58.8 bits (136), Expect = 1e-07
Identities = 53/199 (26%), Positives = 81/199 (40%), Gaps = 12/199 (6%)
Query: 901 KDNITCSEPEEFLLFAQKNAVGRIMVANGECN-DAYIPLTGLKN--VRAIEYDPVEKQLY 957
+ ++T FLL+ Q +G + + DA L L + I+YD E+ +Y
Sbjct: 692 RPDVTPPSVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVY 751
Query: 958 WMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINAT 1017
W D +I R + GL P + +D + RTMYWT + D I +
Sbjct: 752 WTDVAGRTISRAGLELGAEPETIVNS----GLISPEGLAIDHIRRTMYWTDSVLDKIESA 807
Query: 1018 SIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGA--IMRANVDGTGRVELARAD 1075
+D S V+ D + PR +A + L W D R A I +++DG R L D
Sbjct: 808 LLD-GSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTD 866
Query: 1076 NA--TALALDQSAGTVYWA 1092
L D + + WA
Sbjct: 867 IGLPNGLTFDPFSKLLCWA 885
Score = 44.0 bits (99), Expect = 0.003
Identities = 31/132 (23%), Positives = 53/132 (40%), Gaps = 8/132 (6%)
Query: 939 TGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLD 998
+GL + + D + + +YW D I + L P + +D
Sbjct: 777 SGLISPEGLAIDHIRRTMYWTDSVLDKIESALLD-----GSERKVLFYTDLVNPRAIAVD 831
Query: 999 VLGRTMYWTCADRDS--INATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRG 1056
+ +YWT +R++ I +S+D + +++ D LP L F + L W D G
Sbjct: 832 PIRGNLYWTDWNREAPKIETSSLDGENRR-ILINTDIGLPNGLTFDPFSKLLCWADAGTK 890
Query: 1057 AIMRANVDGTGR 1068
+ DGTGR
Sbjct: 891 KLECTLPDGTGR 902
>AJ223500-1|CAA11418.1| 1375|Homo sapiens nidogen-2 protein.
Length = 1375
Score = 153 bits (370), Expect = 5e-36
Identities = 79/228 (34%), Positives = 129/228 (56%), Gaps = 4/228 (1%)
Query: 340 VDFDPKTEYIYWADGLAKTISKARLD-GSDQSVVVRSSGV-PDSIAIDPLSRKIYWTDPV 397
+D+D + +YW D +TIS+A L+ G++ +V S + P+ +AID + R +YWTD V
Sbjct: 1147 IDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSV 1206
Query: 398 MDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRV 457
+D I A LDGS KV+ +T+L +PRAIA+ G ++W+DWN + PKIE ++LDG R
Sbjct: 1207 LDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRR 1266
Query: 458 LLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXXX 517
+LI+ + PN + D + L W DA T K+E DGT R+ + N++ + F
Sbjct: 1267 ILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVI-QNNLKYPFSIVSYA 1325
Query: 518 XXXXXXXMQKRTLDRINKNTG-LDRQPVVEQMANMMGVKAFRLGAPLG 564
++ + +NK++G + + EQ +++ G+ A P G
Sbjct: 1326 DHFYHTDWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITAVYPYCPTG 1373
Score = 125 bits (302), Expect = 8e-28
Identities = 68/193 (35%), Positives = 108/193 (55%), Gaps = 6/193 (3%)
Query: 23 VDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAIDWYTDKLYWTD 82
+D+ R+ ++ W+D I E IV+ GL++P G+AID +YWTD
Sbjct: 1147 IDYDCRERMVYWTDVAGRTISRAGLE--LGAEPETIVNSGLISPEGLAIDHIRRTMYWTD 1204
Query: 83 GETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWG-EIPKIERAGMNGDP 141
+KIE + RKVLF++++ RAIAV P G ++WTDW E PKIE + ++G+
Sbjct: 1205 SVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGE- 1263
Query: 142 ATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVKGGLVYPFAL 201
R++++ +I PNG+T D + L+ W DA + ++ +G R RV++ L YPF++
Sbjct: 1264 -NRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGR-RVIQNNLKYPFSI 1321
Query: 202 TFSNDKLYWTDWQ 214
D Y TDW+
Sbjct: 1322 VSYADHFYHTDWR 1334
Score = 111 bits (266), Expect = 2e-23
Identities = 55/191 (28%), Positives = 102/191 (53%), Gaps = 5/191 (2%)
Query: 652 LYWSDSKTKTINRCSVNGSAVEKIVEWLGLV--EGLAIDWSGQNIYWTDTTTQRIEVSRL 709
+YW+D +TI+R + A + + GL+ EGLAID + +YWTD+ +IE + L
Sbjct: 1156 VYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALL 1215
Query: 710 DGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS--IKRAAMDGSSVSVFME-QVGR 766
DGS R+ + + L P++I +DP +G +YW++ ++ I+ +++DG + + + +G
Sbjct: 1216 DGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGL 1275
Query: 767 VHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPMPYALALFNDSVYWGDWNT 826
+ L D + + WA +E +GTGR+ + +N+ P+++ + D Y DW
Sbjct: 1276 PNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFSIVSYADHFYHTDWRR 1335
Query: 827 GQIQQARKTDG 837
+ K G
Sbjct: 1336 DGVVSVNKHSG 1346
Score = 73.7 bits (173), Expect = 4e-12
Identities = 49/176 (27%), Positives = 88/176 (50%), Gaps = 8/176 (4%)
Query: 681 LVEGLAIDWSGQNIYWTDTTTQRIEVSRLD-GSSRRAIIWQGLKKPKSIVLDPKKGYMYW 739
++ G+ D + +YWTD + I + L+ G+ I+ GL P+ + +D + MYW
Sbjct: 1143 IIVGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYW 1202
Query: 740 SELGSKSIKRAAMDGSSVSV-FMEQVGRVHALAIDYERRAIYWA--ALDPPVVEFAFLNG 796
++ I+ A +DGS V F + A+A+D R +YW + P +E + L+G
Sbjct: 1203 TDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDG 1262
Query: 797 TGRQTLAD-NIPMPYALAL--FNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDY 849
R+ L + +I +P L F+ + W D T ++ + DG+ R+ I+ +L Y
Sbjct: 1263 ENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKL-ECTLPDGTGRRVIQNNLKY 1317
Score = 58.8 bits (136), Expect = 1e-07
Identities = 53/199 (26%), Positives = 81/199 (40%), Gaps = 12/199 (6%)
Query: 901 KDNITCSEPEEFLLFAQKNAVGRIMVANGECN-DAYIPLTGLKN--VRAIEYDPVEKQLY 957
+ ++T FLL+ Q +G + + DA L L + I+YD E+ +Y
Sbjct: 1098 RPDVTPPSVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVY 1157
Query: 958 WMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINAT 1017
W D +I R + GL P + +D + RTMYWT + D I +
Sbjct: 1158 WTDVAGRTISRAGLELGAEPETIVNS----GLISPEGLAIDHIRRTMYWTDSVLDKIESA 1213
Query: 1018 SIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGA--IMRANVDGTGRVELARAD 1075
+D S V+ D + PR +A + L W D R A I +++DG R L D
Sbjct: 1214 LLD-GSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTD 1272
Query: 1076 NA--TALALDQSAGTVYWA 1092
L D + + WA
Sbjct: 1273 IGLPNGLTFDPFSKLLCWA 1291
Score = 44.0 bits (99), Expect = 0.003
Identities = 31/132 (23%), Positives = 53/132 (40%), Gaps = 8/132 (6%)
Query: 939 TGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLD 998
+GL + + D + + +YW D I + L P + +D
Sbjct: 1183 SGLISPEGLAIDHIRRTMYWTDSVLDKIESALLD-----GSERKVLFYTDLVNPRAIAVD 1237
Query: 999 VLGRTMYWTCADRDS--INATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRG 1056
+ +YWT +R++ I +S+D + +++ D LP L F + L W D G
Sbjct: 1238 PIRGNLYWTDWNREAPKIETSSLDGENRR-ILINTDIGLPNGLTFDPFSKLLCWADAGTK 1296
Query: 1057 AIMRANVDGTGR 1068
+ DGTGR
Sbjct: 1297 KLECTLPDGTGR 1308
Score = 33.5 bits (73), Expect = 4.7
Identities = 15/41 (36%), Positives = 19/41 (46%), Gaps = 2/41 (4%)
Query: 566 NPCADDNGGC--SHLCFNRPDDYICGCPLGLELTADKKTCV 604
N CA C + +C N P Y C C G E D+ TC+
Sbjct: 803 NECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCI 843
>AB009799-1|BAA24112.1| 1376|Homo sapiens osteonidogen protein.
Length = 1376
Score = 153 bits (370), Expect = 5e-36
Identities = 79/228 (34%), Positives = 129/228 (56%), Gaps = 4/228 (1%)
Query: 340 VDFDPKTEYIYWADGLAKTISKARLD-GSDQSVVVRSSGV-PDSIAIDPLSRKIYWTDPV 397
+D+D + +YW D +TIS+A L+ G++ +V S + P+ +AID + R +YWTD V
Sbjct: 1148 IDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSV 1207
Query: 398 MDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRV 457
+D I A LDGS KV+ +T+L +PRAIA+ G ++W+DWN + PKIE ++LDG R
Sbjct: 1208 LDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRR 1267
Query: 458 LLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXXX 517
+LI+ + PN + D + L W DA T K+E DGT R+ + N++ + F
Sbjct: 1268 ILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVI-QNNLKYPFSIVSYA 1326
Query: 518 XXXXXXXMQKRTLDRINKNTG-LDRQPVVEQMANMMGVKAFRLGAPLG 564
++ + +NK++G + + EQ +++ G+ A P G
Sbjct: 1327 DHFYHTDWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITAVYPYCPTG 1374
Score = 125 bits (302), Expect = 8e-28
Identities = 68/193 (35%), Positives = 108/193 (55%), Gaps = 6/193 (3%)
Query: 23 VDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIAIDWYTDKLYWTD 82
+D+ R+ ++ W+D I E IV+ GL++P G+AID +YWTD
Sbjct: 1148 IDYDCRERMVYWTDVAGRTISRAGLE--LGAEPETIVNSGLISPEGLAIDHIRRTMYWTD 1205
Query: 83 GETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWG-EIPKIERAGMNGDP 141
+KIE + RKVLF++++ RAIAV P G ++WTDW E PKIE + ++G+
Sbjct: 1206 SVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGE- 1264
Query: 142 ATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVIDFNGEKRKRVVKGGLVYPFAL 201
R++++ +I PNG+T D + L+ W DA + ++ +G R RV++ L YPF++
Sbjct: 1265 -NRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGR-RVIQNNLKYPFSI 1322
Query: 202 TFSNDKLYWTDWQ 214
D Y TDW+
Sbjct: 1323 VSYADHFYHTDWR 1335
Score = 111 bits (266), Expect = 2e-23
Identities = 55/191 (28%), Positives = 102/191 (53%), Gaps = 5/191 (2%)
Query: 652 LYWSDSKTKTINRCSVNGSAVEKIVEWLGLV--EGLAIDWSGQNIYWTDTTTQRIEVSRL 709
+YW+D +TI+R + A + + GL+ EGLAID + +YWTD+ +IE + L
Sbjct: 1157 VYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALL 1216
Query: 710 DGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKS--IKRAAMDGSSVSVFME-QVGR 766
DGS R+ + + L P++I +DP +G +YW++ ++ I+ +++DG + + + +G
Sbjct: 1217 DGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGL 1276
Query: 767 VHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPMPYALALFNDSVYWGDWNT 826
+ L D + + WA +E +GTGR+ + +N+ P+++ + D Y DW
Sbjct: 1277 PNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFSIVSYADHFYHTDWRR 1336
Query: 827 GQIQQARKTDG 837
+ K G
Sbjct: 1337 DGVVSVNKHSG 1347
Score = 73.7 bits (173), Expect = 4e-12
Identities = 49/176 (27%), Positives = 88/176 (50%), Gaps = 8/176 (4%)
Query: 681 LVEGLAIDWSGQNIYWTDTTTQRIEVSRLD-GSSRRAIIWQGLKKPKSIVLDPKKGYMYW 739
++ G+ D + +YWTD + I + L+ G+ I+ GL P+ + +D + MYW
Sbjct: 1144 IIVGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYW 1203
Query: 740 SELGSKSIKRAAMDGSSVSV-FMEQVGRVHALAIDYERRAIYWA--ALDPPVVEFAFLNG 796
++ I+ A +DGS V F + A+A+D R +YW + P +E + L+G
Sbjct: 1204 TDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDG 1263
Query: 797 TGRQTLAD-NIPMPYALAL--FNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDY 849
R+ L + +I +P L F+ + W D T ++ + DG+ R+ I+ +L Y
Sbjct: 1264 ENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKL-ECTLPDGTGRRVIQNNLKY 1318
Score = 58.8 bits (136), Expect = 1e-07
Identities = 53/199 (26%), Positives = 81/199 (40%), Gaps = 12/199 (6%)
Query: 901 KDNITCSEPEEFLLFAQKNAVGRIMVANGECN-DAYIPLTGLKN--VRAIEYDPVEKQLY 957
+ ++T FLL+ Q +G + + DA L L + I+YD E+ +Y
Sbjct: 1099 RPDVTPPSVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVY 1158
Query: 958 WMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINAT 1017
W D +I R + GL P + +D + RTMYWT + D I +
Sbjct: 1159 WTDVAGRTISRAGLELGAEPETIVNS----GLISPEGLAIDHIRRTMYWTDSVLDKIESA 1214
Query: 1018 SIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGA--IMRANVDGTGRVELARAD 1075
+D S V+ D + PR +A + L W D R A I +++DG R L D
Sbjct: 1215 LLD-GSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTD 1273
Query: 1076 NA--TALALDQSAGTVYWA 1092
L D + + WA
Sbjct: 1274 IGLPNGLTFDPFSKLLCWA 1292
Score = 44.0 bits (99), Expect = 0.003
Identities = 31/132 (23%), Positives = 53/132 (40%), Gaps = 8/132 (6%)
Query: 939 TGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLD 998
+GL + + D + + +YW D I + L P + +D
Sbjct: 1184 SGLISPEGLAIDHIRRTMYWTDSVLDKIESALLD-----GSERKVLFYTDLVNPRAIAVD 1238
Query: 999 VLGRTMYWTCADRDS--INATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRG 1056
+ +YWT +R++ I +S+D + +++ D LP L F + L W D G
Sbjct: 1239 PIRGNLYWTDWNREAPKIETSSLDGENRR-ILINTDIGLPNGLTFDPFSKLLCWADAGTK 1297
Query: 1057 AIMRANVDGTGR 1068
+ DGTGR
Sbjct: 1298 KLECTLPDGTGR 1309
Score = 33.5 bits (73), Expect = 4.7
Identities = 15/41 (36%), Positives = 19/41 (46%), Gaps = 2/41 (4%)
Query: 566 NPCADDNGGC--SHLCFNRPDDYICGCPLGLELTADKKTCV 604
N CA C + +C N P Y C C G E D+ TC+
Sbjct: 804 NECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCI 844
>AB209448-1|BAD92685.1| 1241|Homo sapiens nidogen (enactin) variant
protein.
Length = 1241
Score = 151 bits (365), Expect = 2e-35
Identities = 82/254 (32%), Positives = 127/254 (50%), Gaps = 12/254 (4%)
Query: 342 FDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGVPDSIAIDPLSRKIYWTDPVMDTI 401
FD + +YW D +I +A L G + + ++R G IA+D L R I+WTD +D I
Sbjct: 984 FDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQEG----IAVDHLGRNIFWTDSNLDRI 1039
Query: 402 NVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLIS 461
VA+LDG+ +V+ T+L +PR I G ++W+DWN PKIE + +DG+ R +L+
Sbjct: 1040 EVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQ 1099
Query: 462 EKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHSNDIIHIFGXXXXXXXXX 521
+ L PN + D +++L W DA T++ E N R++ + + F
Sbjct: 1100 DDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSYGKNLY 1158
Query: 522 XXXMQKRT---LD-RINKNTGLDRQPVVEQMANMMGVKAFRLGAPLGWNPCADDNGGCSH 577
+ + LD I+K T QP + + G+ P G N C+ +NGGC+H
Sbjct: 1159 FTDWKMNSVVALDLAISKETDAF-QP--HKQTRLYGITTALSQCPQGHNYCSVNNGGCTH 1215
Query: 578 LCFNRPDDYICGCP 591
LC P C CP
Sbjct: 1216 LCLATPGSRTCRCP 1229
Score = 130 bits (315), Expect = 2e-29
Identities = 73/224 (32%), Positives = 119/224 (53%), Gaps = 9/224 (4%)
Query: 63 LVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLMF 122
++ GIA+D ++WTD ++IEV + R+VLF +++ R I G ++
Sbjct: 1014 IIRQEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLY 1073
Query: 123 WTDWG-EIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVID 181
WTDW + PKIE + M+G R+++V+D++ PNG+T D +S + WVDA + ++
Sbjct: 1074 WTDWNRDNPKIETSYMDG--TNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLN 1131
Query: 182 FNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPA 241
+ R++ ++ GL YPFA+T LY+TDW+ S+ D+A + K + + H
Sbjct: 1132 PSQPSRRKALE-GLQYPFAVTSYGKNLYFTDWKMNSVVALDLAIS--KETDAFQPHKQTR 1188
Query: 242 DIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACP 285
+ Q +Y C NN GC+HLCL +P C CP
Sbjct: 1189 LYGITTALSQCPQGHNY-CSVNNGGCTHLCLATPG--SRTCRCP 1229
Score = 123 bits (297), Expect = 3e-27
Identities = 73/261 (27%), Positives = 122/261 (46%), Gaps = 12/261 (4%)
Query: 638 KEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVEGLAIDWSGQNIYWT 697
K + LA +YW+D +I R S++G I+ EG+A+D G+NI+WT
Sbjct: 977 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQ----EGIAVDHLGRNIFWT 1032
Query: 698 DTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELG--SKSIKRAAMDGS 755
D+ RIEV++LDG+ RR + L P+ IV D +G +YW++ + I+ + MDG+
Sbjct: 1033 DSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGT 1092
Query: 756 SVSVFM-EQVGRVHALAIDYERRAIYWAALDPPVVEFAFLNGTGRQTLADNIPMPYALAL 814
+ + + + +G + L D + W E + R+ + + P+A+
Sbjct: 1093 NRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTS 1152
Query: 815 FNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLD-YISDLKLYHRAKSMGSNQCGVDNGG 873
+ ++Y+ DW + + + + + G N C V+NGG
Sbjct: 1153 YGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGG 1212
Query: 874 CSHLCLPTPGDVRTDYRCACP 894
C+HLCL TPG RT C CP
Sbjct: 1213 CTHLCLATPGS-RT---CRCP 1229
Score = 46.8 bits (106), Expect = 5e-04
Identities = 46/191 (24%), Positives = 76/191 (39%), Gaps = 20/191 (10%)
Query: 909 PEEFLLFAQKNAVGRIMVANGECND----AYIPLTGLKNVRAIEYDPVEKQLYWMDDDSH 964
P LLFAQ + R+ + A++ + K + + +D V+K +YW D
Sbjct: 941 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPA-KVIIGLAFDCVDKMVYWTDITEP 999
Query: 965 SIRRVPISYXXXXXXXXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSS 1024
SI R + + R + +D LGR ++WT ++ D I +D +
Sbjct: 1000 SIGRASLHGGEPTT----------IIRQEGIAVDHLGRNIFWTDSNLDRIEVAKLD-GTQ 1048
Query: 1025 TGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRG--AIMRANVDGTGRVELARADNA--TAL 1080
V+ D + PR + + L W D R I + +DGT R L + D L
Sbjct: 1049 RRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGL 1108
Query: 1081 ALDQSAGTVYW 1091
D + + W
Sbjct: 1109 TFDAFSSQLCW 1119
Score = 36.3 bits (80), Expect = 0.66
Identities = 32/136 (23%), Positives = 57/136 (41%), Gaps = 13/136 (9%)
Query: 920 AVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXX 979
++GR + GE P T ++ I D + + ++W D + + R+ ++
Sbjct: 1000 SIGRASLHGGE------PTTIIRQ-EGIAVDHLGRNIFWTDSN---LDRIEVA--KLDGT 1047
Query: 980 XXXXXXXXGLSRPYHMVLDVLGRTMYWTCADRDSINA-TSIDNNSSTGVIVRGDRMLPRH 1038
L P +V D + +YWT +RD+ TS + ++ ++V+ D LP
Sbjct: 1048 QRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNG 1107
Query: 1039 LAFHQTKRYLIWNDVG 1054
L F L W D G
Sbjct: 1108 LTFDAFSSQLCWVDAG 1123
Score = 34.7 bits (76), Expect = 2.0
Identities = 19/69 (27%), Positives = 32/69 (46%), Gaps = 3/69 (4%)
Query: 58 IVSEGLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPE 117
+V + L P G+ D ++ +L W D TN+ E ++ Q R+ L AV
Sbjct: 1097 LVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKAL---EGLQYPFAVTSY 1153
Query: 118 DGLMFWTDW 126
+++TDW
Sbjct: 1154 GKNLYFTDW 1162
>AC068195-1|AAX93243.1| 1126|Homo sapiens unknown protein.
Length = 1126
Score = 129 bits (311), Expect = 7e-29
Identities = 70/176 (39%), Positives = 102/176 (57%), Gaps = 10/176 (5%)
Query: 736 YMYWSELGS-KSIKRAAMDGSSVSVFME-QVGRVHALAIDYERRAIYWAALDPPVVEFAF 793
Y+YW + I R MDG++ SV +E ++ R AL IDY R +YWA D +EF+
Sbjct: 1 YLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWA--DENHIEFSN 58
Query: 794 LNGTGRQTLAD-NIPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISD 852
++G+ R + + +IP AL LF D +YW D T + +A KT G++R S+ I+D
Sbjct: 59 MDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITD 118
Query: 853 LKLYH--RAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
+++YH R + + C ++NGGCSHLCL PG T CACP ++ L DN TC
Sbjct: 119 IQVYHSYRQPDVSKHLCMINNGGCSHLCLLAPGKTHT---CACPTNFYLAADNRTC 171
Score = 102 bits (244), Expect = 9e-21
Identities = 57/176 (32%), Positives = 86/176 (48%), Gaps = 7/176 (3%)
Query: 121 MFWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVI 180
++W D E P I R GM+G + V++ I P +T+DY N +YW D ++
Sbjct: 2 LYWIDCCEYPHIGRVGMDG--TNQSVVIETKISRPMALTIDYVNRRLYWADEN--HIEFS 57
Query: 181 DFNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVP 240
+ +G R +V + ALT D +YWTD + S+ + ++ + H +
Sbjct: 58 NMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAI- 116
Query: 241 ADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSST 296
DI+VY RQ + C NN GCSHLCLL+P + CACPT L ++ T
Sbjct: 117 TDIQVYHSYRQP-DVSKHLCMINNGGCSHLCLLAPGKT-HTCACPTNFYLAADNRT 170
Score = 96.3 bits (229), Expect = 6e-19
Identities = 51/175 (29%), Positives = 88/175 (50%), Gaps = 6/175 (3%)
Query: 433 WMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVC 492
+++W D E P I R +DG+ + ++I K++ P ++ +D VN +LYW D + IE
Sbjct: 1 YLYWIDCCEY-PHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWAD--ENHIEFS 57
Query: 493 NMDGTERKELHSNDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANMM 552
NMDG+ R ++ + DI + + ++L R +K +G DR ++ +
Sbjct: 58 NMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAIT 117
Query: 553 GVKAFR--LGAPLGWNPCADDNGGCSHLCFNRP-DDYICGCPLGLELTADKKTCV 604
++ + + + C +NGGCSHLC P + C CP L AD +TC+
Sbjct: 118 DIQVYHSYRQPDVSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTCL 172
Score = 89.4 bits (212), Expect = 7e-17
Identities = 86/362 (23%), Positives = 151/362 (41%), Gaps = 43/362 (11%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTCV----EPEAFLVYSRKNIIGRLSIKNEYN 628
G CSH C N Y C C + TC+ E + + + +I+G + N
Sbjct: 710 GTCSHQCINVEGSYKCVCDQNFQ--ERNNTCIAEGSEDQVLYIANDTDILGFIYPFNYSG 767
Query: 629 D--AVIPIKDLKEVSALALYVSGSKLYWSDS-KTKTINRCSVNGSAVEKIVEWLGLVE-- 683
D + I+ ++ + +Y + WS I ++G + L E
Sbjct: 768 DHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFK 827
Query: 684 ---GLAIDWSGQNIYWTDTTTQR---------------IEVSRLDGSSRRAIIWQGLKKP 725
+A+DW NIYWTD + I V +L+G + ++ +P
Sbjct: 828 RPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEP 887
Query: 726 KSIVLDPKKGYMYWSELGSKS-IKRAAMDGSSVSVFMEQ-VGRVHALAIDYERRAIYWAA 783
+I ++PK+G MYW+ +G S I+ AAMDG+ + +++ + R LA+DY IYWA
Sbjct: 888 YAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWAD 947
Query: 784 LDPPVVEFAFLNGTGRQTLADN---IPMPYALALFNDSVYWGDWNTGQIQQARKTDGSNR 840
+ ++ +G+ + + P+ + +F D +Y G + + +K +
Sbjct: 948 FELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKNG-VFRVQKFGHGSV 1006
Query: 841 KSIRKDLDYISDLKLYHRAKSMG-SNQCGVDNGGCSHLCLPTPGDVRTDYRCACP-AHYR 898
+ + ++D + + HR K + N C +D C LCL P C CP Y
Sbjct: 1007 EYLALNIDKTKGVLISHRYKQLDLPNPC-LDL-ACEFLCLLNPSGA----TCVCPEGKYL 1060
Query: 899 LN 900
+N
Sbjct: 1061 IN 1062
Score = 89.4 bits (212), Expect = 7e-17
Identities = 79/290 (27%), Positives = 127/290 (43%), Gaps = 37/290 (12%)
Query: 21 TAVDFHYRKNLICWSDQ-KPELIQCMNYNETYTGEKFKIVSEGLVTPT-----GIAIDWY 74
T +D +Y++++I WS Q P I Y + EK + + GL+ P IA+DW
Sbjct: 782 TGMDVYYQRDMIIWSTQFNPGGIF---YKRIHGREK-RQANSGLICPEFKRPRDIAVDWV 837
Query: 75 TDKLYWTDGETN---------------KIEVISIVQKYRKVLFWSEVDLARAIAVVPEDG 119
+YWTD I V + L + AIAV P+ G
Sbjct: 838 AGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRG 897
Query: 120 LMFWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDV 179
+M+WT G+ IE A M+G R+++V+ N+ P G+ VDY + IYW D +L +
Sbjct: 898 MMYWTVVGDHSHIEEAAMDG--TLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGS 955
Query: 180 IDFNGEKRKRVV--KGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSH 237
+ ++G V K GL++P + D +Y +N ++ +G ++ L +
Sbjct: 956 VLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKN-GVFRVQKFGHG-SVEYLALNI 1013
Query: 238 PVPADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTG 287
+ + +Q+ D P + C LCLL+P G C CP G
Sbjct: 1014 DKTKGVLISHRYKQL----DLPNPCLDLACEFLCLLNPS--GATCVCPEG 1057
Score = 57.2 bits (132), Expect = 3e-07
Identities = 36/116 (31%), Positives = 65/116 (56%), Gaps = 9/116 (7%)
Query: 348 YIYWADGLAKT-ISKARLDGSDQSVVVRSS-GVPDSIAIDPLSRKIYWTDPVMDTINVAR 405
Y+YW D I + +DG++QSVV+ + P ++ ID ++R++YW D + I +
Sbjct: 1 YLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADE--NHIEFSN 58
Query: 406 LDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERAN-LDGSGRVLLI 460
+DGS+ + + ++ P IAL L +++W+D K + RA+ G+ R+ LI
Sbjct: 59 MDGSHRHKVPNQDI--PGVIALTLFEDYIYWTDGKTK--SLSRAHKTSGADRLSLI 110
Score = 55.6 bits (128), Expect = 1e-06
Identities = 77/352 (21%), Positives = 129/352 (36%), Gaps = 31/352 (8%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKI-SLDSPDFT 325
CSH C+ Y C C + R N+ Q+L + + I +
Sbjct: 712 CSHQCINVEG--SYKCVCDQNFQERNNTCIAEGSEDQVLYIANDTDILGFIYPFNYSGDH 769
Query: 326 PYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKT-ISKARLDGSDQ-----SVVVRSSGVP 379
++ R +D + + I W+ I R+ G ++ ++ P
Sbjct: 770 QQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFKRP 829
Query: 380 DSIAIDPLSRKIYWTD---------------PVMDTINVARLDGSYEKVIIHTELYDPRA 424
IA+D ++ IYWTD + +INV +L+G ++ +P A
Sbjct: 830 RDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYA 889
Query: 425 IALHLTAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDA 484
IA++ G M+W+ + IE A +DG+ R +L+ + L P +A+D + ++YW D
Sbjct: 890 IAVNPKRGMMYWTVVGDHS-HIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADF 948
Query: 485 RTHKIEVCNMDGTERKELHSN--DIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQ 542
I DG+ S+ ++H K + R+ K +
Sbjct: 949 ELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAG-PKNGVFRVQKFGHGSVE 1007
Query: 543 PVVEQMANMMGVKAFRLGAPLGW-NPCADDNGGCSHLCFNRPDDYICGCPLG 593
+ + GV L NPC D C LC P C CP G
Sbjct: 1008 YLALNIDKTKGVLISHRYKQLDLPNPCLD--LACEFLCLLNPSGATCVCPEG 1057
Score = 49.6 bits (113), Expect = 7e-05
Identities = 32/114 (28%), Positives = 56/114 (49%), Gaps = 8/114 (7%)
Query: 391 IYWTDPV-MDTINVARLDGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKKPKIERA 449
+YW D I +DG+ + V+I T++ P A+ + ++W+D N IE +
Sbjct: 2 LYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADENH----IEFS 57
Query: 450 NLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCN-MDGTERKEL 502
N+DGS R + ++ + P IAL + +YW D +T + + G +R L
Sbjct: 58 NMDGSHRHKVPNQDI--PGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSL 109
Score = 49.2 bits (112), Expect = 9e-05
Identities = 32/101 (31%), Positives = 51/101 (50%), Gaps = 6/101 (5%)
Query: 652 LYWSDS-KTKTINRCSVNGSAVEKIVEW-LGLVEGLAIDWSGQNIYWTDTTTQRIEVSRL 709
LYW D + I R ++G+ ++E + L ID+ + +YW D IE S +
Sbjct: 2 LYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADEN--HIEFSNM 59
Query: 710 DGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSELGSKSIKRA 750
DGS R + Q + P I L + Y+YW++ +KS+ RA
Sbjct: 60 DGSHRHKVPNQDI--PGVIALTLFEDYIYWTDGKTKSLSRA 98
Score = 47.6 bits (108), Expect = 3e-04
Identities = 31/103 (30%), Positives = 38/103 (36%), Gaps = 15/103 (14%)
Query: 1092 AVSRQCDGQQDCEDGRDEAECGA--------CGGDVRC------ADGTXXXXXXXXXXXX 1137
+ S +C+G+ DC DG DE +C C C DG
Sbjct: 466 SASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENC 525
Query: 1138 XXXXXX-XXDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
D F C+ LC +VCDG C D SDEAP C
Sbjct: 526 ERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMC 568
Score = 46.8 bits (106), Expect = 5e-04
Identities = 29/91 (31%), Positives = 33/91 (36%), Gaps = 12/91 (13%)
Query: 1096 QCDGQQDCEDGRDEAECG--ACG-GDVRCADGTXXXXX---------XXXXXXXXXXXXX 1143
+CD Q DC D DE C C D CA+G
Sbjct: 352 RCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNCETSC 411
Query: 1144 XXDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
D FRC G CI A++ CDG C G DE
Sbjct: 412 SKDQFRCSNGQCIPAKWKCDGHEDCKYGEDE 442
Score = 39.1 bits (87), Expect = 0.094
Identities = 14/27 (51%), Positives = 16/27 (59%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDE 1174
F+C GLC F+CDG C D SDE
Sbjct: 220 FQCGTGLCALPAFICDGENDCGDNSDE 246
Score = 37.9 bits (84), Expect = 0.22
Identities = 47/195 (24%), Positives = 75/195 (38%), Gaps = 19/195 (9%)
Query: 989 LSRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYL 1048
+SRP + +D + R +YW AD + I +++D + V ++ +P +A + Y+
Sbjct: 31 ISRPMALTIDYVNRRLYW--ADENHIEFSNMDGSHRHKV---PNQDIPGVIALTLFEDYI 85
Query: 1049 IWNDVGRGAIMRAN-VDGTGRVELARADNATALALDQSAGTVYWAVSRQCDGQQDC--ED 1105
W D ++ RA+ G R+ L + +A + VY + + + C +
Sbjct: 86 YWTDGKTKSLSRAHKTSGADRLSLIYSWHAI------TDIQVYHSYRQPDVSKHLCMINN 139
Query: 1106 GRDEAECGACGGDVR-CADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDG 1164
G C G CA T FRC CI + CD
Sbjct: 140 GGCSHLCLLAPGKTHTCACPT---NFYLAADNRTCLSNCTASQFRCKTDKCIPFWWKCDT 196
Query: 1165 RPQCADGSDEAPAAC 1179
C DGSDE P C
Sbjct: 197 VDDCGDGSDE-PDDC 210
Score = 35.9 bits (79), Expect = 0.87
Identities = 28/94 (29%), Positives = 33/94 (35%), Gaps = 15/94 (15%)
Query: 1097 CDGQQDCEDGRDEAECGA--C-GGDVRCADGTXXXXXXXXXXXXXX-----------XXX 1142
CDG+ DC D DE C C G +C
Sbjct: 234 CDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENS 293
Query: 1143 XXXDAFRCDEGL-CIAARFVCDGRPQCADGSDEA 1175
D F+C CI+ +VCD P CAD SDEA
Sbjct: 294 CSPDYFQCKTTKHCISKLWVCDEDPDCADASDEA 327
Score = 34.7 bits (76), Expect = 2.0
Identities = 25/96 (26%), Positives = 36/96 (37%), Gaps = 14/96 (14%)
Query: 1093 VSRQCDGQQDCEDGRDEAEC--GACGGD-VRCADGTXXXXXXXXXXXXXXXXXXXXDA-- 1147
V+ +C+GQ DC D DE +C +C D +C +A
Sbjct: 270 VNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANC 329
Query: 1148 ---------FRCDEGLCIAARFVCDGRPQCADGSDE 1174
F+C CI + CD + C+D SDE
Sbjct: 330 DKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDE 365
Score = 32.7 bits (71), Expect = 8.1
Identities = 22/89 (24%), Positives = 36/89 (40%), Gaps = 4/89 (4%)
Query: 1004 MYWT-CADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGAIMRAN 1062
+YW C + I +D + + V++ P L R L W D I +N
Sbjct: 2 LYWIDCCEYPHIGRVGMDGTNQS-VVIETKISRPMALTIDYVNRRLYWADENH--IEFSN 58
Query: 1063 VDGTGRVELARADNATALALDQSAGTVYW 1091
+DG+ R ++ D +AL +YW
Sbjct: 59 MDGSHRHKVPNQDIPGVIALTLFEDYIYW 87
Score = 32.7 bits (71), Expect = 8.1
Identities = 20/78 (25%), Positives = 37/78 (47%), Gaps = 5/78 (6%)
Query: 58 IVSEGLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPE 117
++ + P + ID+ +LYW D N IE ++ +R + D+ IA+
Sbjct: 26 VIETKISRPMALTIDYVNRRLYWAD--ENHIEFSNMDGSHRHKV--PNQDIPGVIALTLF 81
Query: 118 DGLMFWTDWGEIPKIERA 135
+ ++WTD G+ + RA
Sbjct: 82 EDYIYWTD-GKTKSLSRA 98
>BC021204-1|AAH21204.1| 439|Homo sapiens LRP1 protein protein.
Length = 439
Score = 103 bits (247), Expect = 4e-21
Identities = 63/195 (32%), Positives = 105/195 (53%), Gaps = 9/195 (4%)
Query: 9 RITTIAK-DLEQGTAVDFHYRKNLICW---SDQKPEL-IQC--MNYNETYTGEKFKIVSE 61
+++TI Q TA+DF Y +CW D + ++C M + + E +S
Sbjct: 218 QVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISL 277
Query: 62 GLVTPTGIAIDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDGLM 121
L +AIDW T Y+ D ++I V + L E+ + IA+ P G +
Sbjct: 278 SLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKV 337
Query: 122 FWTDWGEIPKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVID 181
F+TD+G+IPK+ER M+G T+ +V I +P+GIT+D + L+YW DA L +++V+D
Sbjct: 338 FFTDYGQIPKVERCDMDGQNRTK--LVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVD 395
Query: 182 FNGEKRKRVVKGGLV 196
+ G+ R+ +++G LV
Sbjct: 396 YEGKGRQTIIQGILV 410
Score = 98.7 bits (235), Expect = 1e-19
Identities = 73/250 (29%), Positives = 120/250 (48%), Gaps = 19/250 (7%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLR-ENSSTTCYDSP---QMLLVVAQRSTISKISLDSP 322
CS LC + + C C G L+ +N S + P +L++A I L
Sbjct: 160 CSQLCTNTDG--SFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGA 217
Query: 323 DFTPYTLPLKDLKRTLTVDFDPKTEYIYWA---DGLAKTISK-ARLDGS----DQSVVVR 374
+ T+ ++T +DF E + W D A+T K AR+ G D+ +
Sbjct: 218 QVS--TITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINI 275
Query: 375 SSGVP--DSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAG 432
S + + +AID L+ Y+ D + D I V +G ++ ELY+P+ IAL G
Sbjct: 276 SLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMG 335
Query: 433 WMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVC 492
+F++D+ + PK+ER ++DG R L+ K+ +P+ I LD V+ +YW DA IEV
Sbjct: 336 KVFFTDYGQI-PKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVV 394
Query: 493 NMDGTERKEL 502
+ +G R+ +
Sbjct: 395 DYEGKGRQTI 404
Score = 93.1 bits (221), Expect = 5e-18
Identities = 72/274 (26%), Positives = 120/274 (43%), Gaps = 25/274 (9%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTCV-------EPEAFLVYSRKNIIGRLSIKN 625
G CS LC N +ICGC G L D ++C P L+ + +NI+ +
Sbjct: 158 GTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATY-LSG 216
Query: 626 EYNDAVIPIKDLKEVSALALYVSGSKLYW---SDSKTKTINRCS----VNGSAVEKIVEW 678
+ P ++ +A+ + + W DS +T +C+ + G E +
Sbjct: 217 AQVSTITPTST-RQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINI 275
Query: 679 ---LGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKG 735
L VE +AIDW N Y+ D RI V +G + ++ L PK I LDP G
Sbjct: 276 SLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMG 335
Query: 736 YMYWSELGS-KSIKRAAMDGSSVSVFME-QVGRVHALAIDYERRAIYWAALDPPVVEFAF 793
+++++ G ++R MDG + + ++ ++ H + +D R +YWA +E
Sbjct: 336 KVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVD 395
Query: 794 LNGTGRQTLADNIPMPYALALFNDSVYWGDWNTG 827
G GRQT+ I + L+ V WG+ + G
Sbjct: 396 YEGKGRQTIIQGILVRELLS----EVLWGNHDPG 425
Score = 39.9 bits (89), Expect = 0.054
Identities = 63/261 (24%), Positives = 106/261 (40%), Gaps = 22/261 (8%)
Query: 266 GCSHLCLLSPDPPGYNCACPTGVKLRENSSTTC-YDSPQMLLVVAQRSTISKISLDSPDF 324
GC H C+ + D P C C + +L+ + T +D + +Q T + S
Sbjct: 119 GCQHHCVPTLDGP--TCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCV 176
Query: 325 TPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGVPDSIAI 384
Y L + R+ +P ++ I L G+ S + +S + A+
Sbjct: 177 EGYLLQPDN--RSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTS-TRQTTAM 233
Query: 385 D--PLSRKIYWT---DPVMDT-INVARLDGSYEKVIIHT-----ELYDPRAIALH-LTAG 432
D + + W D T + AR+ G V HT L+ +A+ LT
Sbjct: 234 DFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGN 293
Query: 433 WMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGD-ARTHKIEV 491
+ F D +++ I N +G V L+ +L P IALD K+++ D + K+E
Sbjct: 294 FYFVDDIDDR---IFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVER 350
Query: 492 CNMDGTERKELHSNDIIHIFG 512
C+MDG R +L + I+ G
Sbjct: 351 CDMDGQNRTKLVDSKIVFPHG 371
Score = 39.1 bits (87), Expect = 0.094
Identities = 17/33 (51%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 1148 FRC-DEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F C D+ CI+ + CDG C DGSDEAP C
Sbjct: 32 FACRDQITCISKGWRCDGERDCPDGSDEAPEIC 64
>AC108036-1|AAX93208.1| 449|Homo sapiens unknown protein.
Length = 449
Score = 100 bits (240), Expect = 3e-20
Identities = 66/224 (29%), Positives = 108/224 (48%), Gaps = 12/224 (5%)
Query: 68 GIAIDWYTDKLYWTDGETNKIEVISIVQKY------RKVLFWSEVDLARAIAVVPEDGLM 121
G+A D LYWT T+ I ++ Q V+ SE D +A+ LM
Sbjct: 6 GLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLM 65
Query: 122 FWTDWGEI-PKIERAGMNGDPATRKVIVRDNIFWPNGITVDYNNSLIYWVDAKLQFVDVI 180
FWT+W E P I R+ + G A +V+V +I PNG+T+DY +Y+ D L ++
Sbjct: 66 FWTNWNEQHPSIMRSTLTGKNA--QVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERC 123
Query: 181 DFNGEKRKRVVKGGLVYPFALTFSNDKLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVP 240
+++G +R +VK G +L ++ ++W+DW +I + G ++++S
Sbjct: 124 EYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGD--TKILRSDIPH 181
Query: 241 ADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCAC 284
+ + + S E PC N GC LCLL+P+ NC+C
Sbjct: 182 QPMGIIAVANDTNSCELSPCALLNGGCHDLCLLTPN-GRVNCSC 224
Score = 93.9 bits (223), Expect = 3e-18
Identities = 70/279 (25%), Positives = 125/279 (44%), Gaps = 21/279 (7%)
Query: 679 LGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGS-----SRRAIIWQGLKK-PKSIVLDP 732
+G VEGLA + +YWT +TT I +D + R A+I P + LD
Sbjct: 1 VGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDE 60
Query: 733 KKGYMYWSELGSK--SIKRAAMDGSSVSVFME-QVGRVHALAIDYERRAIYWAALDPPVV 789
+ M+W+ + SI R+ + G + V + + + L IDY +Y++ +
Sbjct: 61 CQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKI 120
Query: 790 EFAFLNGTGRQTLADNIPMPY-ALALFNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLD 848
E +G+ R + + P + +LA++++ ++W DW I ++ K G + K +R D+
Sbjct: 121 ERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIP 180
Query: 849 Y--ISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
+ + + + + S + C + NGGC LCL TP C+C L +DN
Sbjct: 181 HQPMGIIAVANDTNSCELSPCALLNGGCHDLCLLTPNG---RVNCSCRGDRILLEDNRCV 237
Query: 907 SEPEEFLLFAQKNAVGRIMVANGECNDAYIPLTGLKNVR 945
++ + NA NGEC D + G+ + +
Sbjct: 238 TKN------SSCNAYSEFECGNGECIDYQLTCDGIPHCK 270
Score = 91.1 bits (216), Expect = 2e-17
Identities = 63/223 (28%), Positives = 99/223 (44%), Gaps = 10/223 (4%)
Query: 391 IYWTDPVMDTINVARLD----GSYEK--VIIHTELYDPRAIALHLTAGWMFWSDWNEKKP 444
+YWT +I +D G++++ VI +E P +AL MFW++WNE+ P
Sbjct: 16 LYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQHP 75
Query: 445 KIERANLDGSGRVLLISEKLTWPNSIALDTVNNKLYWGDARTHKIEVCNMDGTERKELHS 504
I R+ L G +++S + PN + +D KLY+ D KIE C DG++R +
Sbjct: 76 SIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVIVK 135
Query: 505 NDIIHIFGXXXXXXXXXXXXMQKRTLDRINKNTGLDRQPVVEQMANM-MGVKAFRLGA-P 562
+ +R + R NK TG D + + + + MG+ A
Sbjct: 136 SGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQPMGIIAVANDTNS 195
Query: 563 LGWNPCADDNGGCSHLCFNRPDDYI-CGCPLGLELTADKKTCV 604
+PCA NGGC LC P+ + C C G + + CV
Sbjct: 196 CELSPCALLNGGCHDLCLLTPNGRVNCSC-RGDRILLEDNRCV 237
Score = 58.0 bits (134), Expect = 2e-07
Identities = 32/95 (33%), Positives = 52/95 (54%), Gaps = 8/95 (8%)
Query: 34 WSDQKPELIQCMNYNETYTGEKFKIV-SEGLVTPTGIAIDWYTDKLYWTDGETNKIEVIS 92
W++Q P +++ T TG+ ++V S ++TP G+ ID+ +KLY++DG KIE
Sbjct: 70 WNEQHPSIMR-----STLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCE 124
Query: 93 IVQKYRKVLFWSEVDLARAIAVVPEDGLMFWTDWG 127
R V+ S ++AV D +FW+DWG
Sbjct: 125 YDGSQRHVIVKSGPGTFLSLAVY--DNYIFWSDWG 157
Score = 44.8 bits (101), Expect = 0.002
Identities = 47/191 (24%), Positives = 65/191 (34%), Gaps = 11/191 (5%)
Query: 992 PYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWN 1051
P + +D +Y++ I D S VIV+ LA + Y+ W+
Sbjct: 98 PNGLTIDYRAEKLYFSDGSLGKIERCEYDG-SQRHVIVKSGPGTFLSLAVYDN--YIFWS 154
Query: 1052 DVGRGAIMRANVDGTGRVELARADNATALALDQSAGTVYWAVSRQCDGQQDCE--DGRDE 1109
D GR AI+R+N G ++ R+D Q G + A C +G
Sbjct: 155 DWGRRAILRSNKYTGGDTKILRSDIP-----HQPMGIIAVANDTNSCELSPCALLNGGCH 209
Query: 1110 AECGAC-GGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQC 1168
C G V C+ F C G CI + CDG P C
Sbjct: 210 DLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAYSEFECGNGECIDYQLTCDGIPHC 269
Query: 1169 ADGSDEAPAAC 1179
D SDE C
Sbjct: 270 KDKSDEKLLYC 280
Score = 42.7 bits (96), Expect = 0.008
Identities = 24/86 (27%), Positives = 45/86 (52%), Gaps = 3/86 (3%)
Query: 358 TISKARLDGSDQSVVVRSSGV-PDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIH 416
+I ++ L G + VVV + + P+ + ID + K+Y++D + I DGS VI+
Sbjct: 76 SIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVIVK 135
Query: 417 TELYDPRAIALHLTAGWMFWSDWNEK 442
+ ++L + ++FWSDW +
Sbjct: 136 SG--PGTFLSLAVYDNYIFWSDWGRR 159
Score = 40.7 bits (91), Expect = 0.031
Identities = 33/153 (21%), Positives = 58/153 (37%), Gaps = 4/153 (2%)
Query: 943 NVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGLS-RPYHMVLDVLG 1001
+V + Y LYW + SI R + P+ + LD
Sbjct: 3 SVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQ 62
Query: 1002 RTMYWTCADRD--SINATSIDNNSSTGVIVRGDRMLPRHLAFHQTKRYLIWNDVGRGAIM 1059
M+WT + SI +++ ++ V+V D + P L L ++D G I
Sbjct: 63 NLMFWTNWNEQHPSIMRSTLTGKNAQ-VVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIE 121
Query: 1060 RANVDGTGRVELARADNATALALDQSAGTVYWA 1092
R DG+ R + ++ T L+L ++W+
Sbjct: 122 RCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWS 154
Score = 37.1 bits (82), Expect = 0.38
Identities = 13/16 (81%), Positives = 14/16 (87%)
Query: 1097 CDGQQDCEDGRDEAEC 1112
CDGQ+DCEDGRDE C
Sbjct: 434 CDGQKDCEDGRDEFHC 449
Score = 36.7 bits (81), Expect = 0.50
Identities = 16/32 (50%), Positives = 19/32 (59%), Gaps = 3/32 (9%)
Query: 1097 CDGQQDCEDGRDEAEC--GACGG-DVRCADGT 1125
CDG+ DC D DE +C C + RCADGT
Sbjct: 304 CDGENDCGDNSDELDCKVSTCATVEFRCADGT 335
Score = 36.7 bits (81), Expect = 0.50
Identities = 22/88 (25%), Positives = 30/88 (34%), Gaps = 2/88 (2%)
Query: 1103 CEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAF-RCDE-GLCIAARF 1160
C DG C ++ CAD + F RC+ LC+ +
Sbjct: 331 CADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTW 390
Query: 1161 VCDGRPQCADGSDEAPAACAYGHTDQVN 1188
+CDG C D SDE H + N
Sbjct: 391 ICDGSNDCGDYSDELKCPVQNKHKCEEN 418
Score = 36.7 bits (81), Expect = 0.50
Identities = 13/27 (48%), Positives = 16/27 (59%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDE 1174
F C G CI ++CDG+ C DG DE
Sbjct: 420 FSCPSGRCILNTWICDGQKDCEDGRDE 446
Score = 35.9 bits (79), Expect = 0.87
Identities = 18/58 (31%), Positives = 33/58 (56%), Gaps = 3/58 (5%)
Query: 338 LTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVRSSGVPDSIAIDPLSRKIYWTD 395
LT+D+ + E +Y++DG I + DGS + V+V+ SG +++ I+W+D
Sbjct: 101 LTIDY--RAEKLYFSDGSLGKIERCEYDGSQRHVIVK-SGPGTFLSLAVYDNYIFWSD 155
>AC093039-1|AAX88911.1| 425|Homo sapiens unknown protein.
Length = 425
Score = 90.2 bits (214), Expect = 4e-17
Identities = 52/171 (30%), Positives = 89/171 (52%), Gaps = 11/171 (6%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLRENSSTTC--YDSPQMLLVVAQRSTISKISLDSPDF 324
CS C+ + Y C C G +++ ++ C + L++A I KIS D +
Sbjct: 261 CSQQCINTYGT--YKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSN- 317
Query: 325 TPYTLPLKDLKRTLTVDFDPKTEYIYWADGL---AKTISKARLDGSDQSVVVRSSGVPDS 381
YTL + L + +DFD + E+IYW D I++ L+GSD VV ++ VP++
Sbjct: 318 --YTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVV-HNTAVPNA 374
Query: 382 IAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAG 432
+A+D + + +YW+D I V++L+G Y +++ L PR ++L AG
Sbjct: 375 LAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAG 425
Score = 86.6 bits (205), Expect = 5e-16
Identities = 54/168 (32%), Positives = 86/168 (51%), Gaps = 10/168 (5%)
Query: 575 CSHLCFNRPDDYICGCPLGLELTADK----KTCVEPEAFLVYSRKNIIGRLSIKNEYNDA 630
CS C N Y C C G E+ D K+ + E FL+ + + I ++S + ++
Sbjct: 261 CSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKIS--TDGSNY 318
Query: 631 VIPIKDLKEVSALALYVSGSKLYWSDSKTKT---INRCSVNGSAVEKIVEWLGLVEGLAI 687
+ + L V A+ +YW DS INR +NGS + K+V + LA+
Sbjct: 319 TLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDI-KVVHNTAVPNALAV 377
Query: 688 DWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKG 735
DW G+N+YW+DT + IEVS+L+G ++ + LK P+ + LDP+ G
Sbjct: 378 DWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAG 425
Score = 54.0 bits (124), Expect = 3e-06
Identities = 32/109 (29%), Positives = 48/109 (44%), Gaps = 2/109 (1%)
Query: 11 TTIAKDLEQGTAVDFHYRKNLICWSDQKPELIQCMNYNETYTGEKFKIVSEGLVTPTGIA 70
T + + L A+DF YR+ I W D +N G K+V V P +A
Sbjct: 319 TLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRIN-RMCLNGSDIKVVHNTAV-PNALA 376
Query: 71 IDWYTDKLYWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDG 119
+DW LYW+D E IEV + Y +L + R +++ P+ G
Sbjct: 377 VDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAG 425
Score = 51.2 bits (117), Expect = 2e-05
Identities = 64/224 (28%), Positives = 104/224 (46%), Gaps = 30/224 (13%)
Query: 262 KNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDS-------PQMLLVVAQRSTI 314
K +GCS C P Y C C G +L+++ T C D P + T
Sbjct: 216 KKVSGCSQDC--QDLPVSYKCKCWPGFQLKDDGKT-CVDIDECSSGFPCSQQCINTYGTY 272
Query: 315 SKISLDSPDFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLAKTISKARLDGSDQSVVVR 374
+ D + P + ++L+ D +P ++ AD I K DGS+ +++
Sbjct: 273 KCLCTDGYEIQPDN---PNGCKSLS-DEEP---FLILADH--HEIRKISTDGSNYTLL-- 321
Query: 375 SSGVPDSIAIDPLSRK--IYWTD---PVMDTINVARLDGSYEKVIIHTELYDPRAIALHL 429
G+ + IAID R+ IYW D P IN L+GS KV+ +T + P A+A+
Sbjct: 322 KQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAV--PNALAVDW 379
Query: 430 TAGWMFWSDWNEKKPKIERANLDGSGRVLLISEKLTWPNSIALD 473
++WSD +K IE + L+G +L+S++L +P ++LD
Sbjct: 380 IGKNLYWSD--TEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLD 421
Score = 50.8 bits (116), Expect = 3e-05
Identities = 41/171 (23%), Positives = 75/171 (43%), Gaps = 16/171 (9%)
Query: 874 CSHLCLPTPGDVRTDYRCACPAHYRLNKDNIT-C---SEPEEFLLFAQKNAVGRIMVANG 929
CS C+ T G Y+C C Y + DN C S+ E FL+ A + + +I
Sbjct: 261 CSQQCINTYGT----YKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKIST--- 313
Query: 930 ECNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVPISYXXXXXXXXXXXXXXGL 989
+ ++ + GL NV AI++D E+ +YW+D + R+
Sbjct: 314 DGSNYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRI----NRMCLNGSDIKVVHNT 369
Query: 990 SRPYHMVLDVLGRTMYWTCADRDSINATSIDNNSSTGVIVRGDRMLPRHLA 1040
+ P + +D +G+ +YW+ ++ I + ++ T ++V PR L+
Sbjct: 370 AVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPT-ILVSKRLKFPRDLS 419
Score = 50.4 bits (115), Expect = 4e-05
Identities = 29/85 (34%), Positives = 37/85 (43%), Gaps = 23/85 (27%)
Query: 1097 CDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCI 1156
CDG++DC DG DE C + C + +AF C +CI
Sbjct: 64 CDGERDCPDGSDELSTAGCAPNNTCDE----------------------NAFMCHNKVCI 101
Query: 1157 AARFVCDGRPQCADGSDEAPAACAY 1181
+FVCD C DGSDE+P C Y
Sbjct: 102 PKQFVCDHDDDCGDGSDESP-QCGY 125
Score = 44.8 bits (101), Expect = 0.002
Identities = 26/90 (28%), Positives = 48/90 (53%), Gaps = 5/90 (5%)
Query: 710 DGSSRRAIIWQGLKKPKSIVLDPKKGYMYW---SELGSKSIKRAAMDGSSVSVFMEQVGR 766
DGS+ ++ QGL +I D ++ ++YW S I R ++GS + V +
Sbjct: 314 DGSNY-TLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKV-VHNTAV 371
Query: 767 VHALAIDYERRAIYWAALDPPVVEFAFLNG 796
+ALA+D+ + +YW+ + ++E + LNG
Sbjct: 372 PNALAVDWIGKNLYWSDTEKRIIEVSKLNG 401
Score = 42.3 bits (95), Expect = 0.010
Identities = 31/94 (32%), Positives = 40/94 (42%), Gaps = 26/94 (27%)
Query: 1097 CDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEG-LC 1155
CDG+ DC DG DE++ CG + CA D F C C
Sbjct: 22 CDGEDDCGDGLDESD-SICGA-ITCA----------------------ADMFSCQGSRAC 57
Query: 1156 IAARFVCDGRPQCADGSDE-APAACAYGHTDQVN 1188
+ ++CDG C DGSDE + A CA +T N
Sbjct: 58 VPRHWLCDGERDCPDGSDELSTAGCAPNNTCDEN 91
Score = 41.9 bits (94), Expect = 0.013
Identities = 49/196 (25%), Positives = 80/196 (40%), Gaps = 12/196 (6%)
Query: 566 NPCADDN-GGCSHLCFNRPDDYICGCPLGLELTADKKTCV---EPEAFLVYSRKNIIGRL 621
N C GCS C + P Y C C G +L D KTCV E + S++ I
Sbjct: 211 NECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYG 270
Query: 622 SIKNEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGL 681
+ K D I+ +L L +D I + S +GS + + L
Sbjct: 271 TYKCLCTDG-YEIQPDNPNGCKSLSDEEPFLILADH--HEIRKISTDGSNYTLLKQGLNN 327
Query: 682 VEGLAIDWSGQNIYWTDTTT---QRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMY 738
V + D+ + IYW D++ RI L+GS + + P ++ +D +Y
Sbjct: 328 VIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVV--HNTAVPNALAVDWIGKNLY 385
Query: 739 WSELGSKSIKRAAMDG 754
WS+ + I+ + ++G
Sbjct: 386 WSDTEKRIIEVSKLNG 401
Score = 39.9 bits (89), Expect = 0.054
Identities = 25/82 (30%), Positives = 31/82 (37%), Gaps = 4/82 (4%)
Query: 1095 RQCDGQQ-DCEDGRDEAECG-ACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDE 1152
RQC ++ C DGR C GD C D + F C
Sbjct: 126 RQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSF--FMCKN 183
Query: 1153 GLCIAARFVCDGRPQCADGSDE 1174
G CI + +CD + C DGSDE
Sbjct: 184 GRCIPSGGLCDNKDDCGDGSDE 205
Score = 38.3 bits (85), Expect = 0.16
Identities = 13/32 (40%), Positives = 18/32 (56%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F C CI+ ++CDG C DG DE+ + C
Sbjct: 8 FACSAQKCISKHWICDGEDDCGDGLDESDSIC 39
Score = 37.9 bits (84), Expect = 0.22
Identities = 25/91 (27%), Positives = 42/91 (46%), Gaps = 4/91 (4%)
Query: 407 DGSYEKVIIHTELYDPRAIALHLTAGWMFWSDWNEKK-PKIERANLDGSGRVLLISEKLT 465
DGS ++ L + AI +++W D + +I R L+GS + +
Sbjct: 314 DGS-NYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSD--IKVVHNTA 370
Query: 466 WPNSIALDTVNNKLYWGDARTHKIEVCNMDG 496
PN++A+D + LYW D IEV ++G
Sbjct: 371 VPNALAVDWIGKNLYWSDTEKRIIEVSKLNG 401
Score = 37.5 bits (83), Expect = 0.29
Identities = 29/114 (25%), Positives = 51/114 (44%), Gaps = 6/114 (5%)
Query: 747 IKRAAMDGSSVSVFMEQVGRVHALAIDYERRAIYWAALDPP---VVEFAFLNGTGRQTLA 803
I++ + DGS+ ++ + + V A+ DY IYW P + LNG+ + +
Sbjct: 308 IRKISTDGSNYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIK-VV 366
Query: 804 DNIPMPYALAL--FNDSVYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKL 855
N +P ALA+ ++YW D I+ ++ + K L + DL L
Sbjct: 367 HNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSL 420
Score = 32.7 bits (71), Expect = 8.1
Identities = 14/32 (43%), Positives = 19/32 (59%), Gaps = 1/32 (3%)
Query: 1146 DAFRCDEGLCIA-ARFVCDGRPQCADGSDEAP 1176
+ F C +G C+ ++ CDG C D SDEAP
Sbjct: 131 EEFSCADGRCLLNTQWQCDGDFDCPDHSDEAP 162
>AC110087-1|AAY24167.1| 132|Homo sapiens unknown protein.
Length = 132
Score = 89.0 bits (211), Expect = 9e-17
Identities = 42/131 (32%), Positives = 66/131 (50%), Gaps = 3/131 (2%)
Query: 819 VYWGDWNTGQIQQARKTDGSNRKSIRKDLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLC 878
++W D N Q+ K DG N +R + +K+Y + GSN C ++NGGCS LC
Sbjct: 3 LWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLC 62
Query: 879 LPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVANGECNDAYIPL 938
LPT RT C C Y L K+ ++C E FL+++ + I + + DA +P+
Sbjct: 63 LPTSETTRT---CMCTVGYYLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMDALMPI 119
Query: 939 TGLKNVRAIEY 949
+G I++
Sbjct: 120 SGTSFAVGIDF 130
Score = 47.6 bits (108), Expect = 3e-04
Identities = 31/107 (28%), Positives = 53/107 (49%), Gaps = 2/107 (1%)
Query: 530 LDRINKNTGLDRQPVVEQMANMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRPD-DYIC 588
L +K G + + + + ++ +K + A G N C +NGGCS LC + C
Sbjct: 13 LGTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLCLPTSETTRTC 72
Query: 589 GCPLGLELTADKKTCVEPEAFLVYS-RKNIIGRLSIKNEYNDAVIPI 634
C +G L ++ +C E+FL+YS + I G ++ DA++PI
Sbjct: 73 MCTVGYYLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMDALMPI 119
Score = 41.1 bits (92), Expect = 0.023
Identities = 37/136 (27%), Positives = 56/136 (41%), Gaps = 7/136 (5%)
Query: 207 KLYWTDWQNWSIYTWDIAANGPKIKELIKSHPVPADIKVYDESRQIISAEDYPCKKNNAG 266
KL+W D QN + +G L +KVYD+ Q S C+ NN G
Sbjct: 2 KLWWAD-QNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNS---CQLNNGG 57
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISLDSPDFTP 326
CS LCL + + C C G L++N +C + L+ + I I L+ D
Sbjct: 58 CSQLCLPTSETT-RTCMCTVGYYLQKN-RMSC-QGIESFLMYSVHEGIRGIPLEPSDKMD 114
Query: 327 YTLPLKDLKRTLTVDF 342
+P+ + +DF
Sbjct: 115 ALMPISGTSFAVGIDF 130
>BC113716-1|AAI13717.1| 713|Homo sapiens low density lipoprotein
receptor-related protein 10 protein.
Length = 713
Score = 57.2 bits (132), Expect = 3e-07
Identities = 35/112 (31%), Positives = 47/112 (41%), Gaps = 15/112 (13%)
Query: 1078 TALALDQSAGTVYWAVSRQCDGQQDCEDGRDEAECGACG-GDVRC-ADGTXXXXXXXXXX 1135
+ L + G ++ +++CDG DC DG DE +C C G C A GT
Sbjct: 319 SGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATACYLPA 378
Query: 1136 XXXXXXXXXXDA-------------FRCDEGLCIAARFVCDGRPQCADGSDE 1174
D FRC + C+ +VCDG+P CADGSDE
Sbjct: 379 DRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDE 430
Score = 33.5 bits (73), Expect = 4.7
Identities = 14/30 (46%), Positives = 18/30 (60%)
Query: 1146 DAFRCDEGLCIAARFVCDGRPQCADGSDEA 1175
+ F+C C++A CDG C DGSDEA
Sbjct: 143 EEFQCLNHRCVSAVQRCDGVDACGDGSDEA 172
>BC113714-1|AAI13715.1| 713|Homo sapiens low density lipoprotein
receptor-related protein 10 protein.
Length = 713
Score = 57.2 bits (132), Expect = 3e-07
Identities = 35/112 (31%), Positives = 47/112 (41%), Gaps = 15/112 (13%)
Query: 1078 TALALDQSAGTVYWAVSRQCDGQQDCEDGRDEAECGACG-GDVRC-ADGTXXXXXXXXXX 1135
+ L + G ++ +++CDG DC DG DE +C C G C A GT
Sbjct: 319 SGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATACYLPA 378
Query: 1136 XXXXXXXXXXDA-------------FRCDEGLCIAARFVCDGRPQCADGSDE 1174
D FRC + C+ +VCDG+P CADGSDE
Sbjct: 379 DRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDE 430
Score = 33.5 bits (73), Expect = 4.7
Identities = 14/30 (46%), Positives = 18/30 (60%)
Query: 1146 DAFRCDEGLCIAARFVCDGRPQCADGSDEA 1175
+ F+C C++A CDG C DGSDEA
Sbjct: 143 EEFQCLNHRCVSAVQRCDGVDACGDGSDEA 172
>BC064901-1|AAH64901.1| 457|Homo sapiens LRP10 protein protein.
Length = 457
Score = 57.2 bits (132), Expect = 3e-07
Identities = 35/112 (31%), Positives = 47/112 (41%), Gaps = 15/112 (13%)
Query: 1078 TALALDQSAGTVYWAVSRQCDGQQDCEDGRDEAECGACG-GDVRC-ADGTXXXXXXXXXX 1135
+ L + G ++ +++CDG DC DG DE +C C G C A GT
Sbjct: 220 SGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATACYLPA 279
Query: 1136 XXXXXXXXXXDA-------------FRCDEGLCIAARFVCDGRPQCADGSDE 1174
D FRC + C+ +VCDG+P CADGSDE
Sbjct: 280 DRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDE 331
Score = 33.5 bits (73), Expect = 4.7
Identities = 14/30 (46%), Positives = 18/30 (60%)
Query: 1146 DAFRCDEGLCIAARFVCDGRPQCADGSDEA 1175
+ F+C C++A CDG C DGSDEA
Sbjct: 44 EEFQCLNHRCVSAVQRCDGVDACGDGSDEA 73
>AY358399-1|AAQ88765.1| 713|Homo sapiens LRP10 protein.
Length = 713
Score = 57.2 bits (132), Expect = 3e-07
Identities = 35/112 (31%), Positives = 47/112 (41%), Gaps = 15/112 (13%)
Query: 1078 TALALDQSAGTVYWAVSRQCDGQQDCEDGRDEAECGACG-GDVRC-ADGTXXXXXXXXXX 1135
+ L + G ++ +++CDG DC DG DE +C C G C A GT
Sbjct: 319 SGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATACYLPA 378
Query: 1136 XXXXXXXXXXDA-------------FRCDEGLCIAARFVCDGRPQCADGSDE 1174
D FRC + C+ +VCDG+P CADGSDE
Sbjct: 379 DRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDE 430
Score = 33.5 bits (73), Expect = 4.7
Identities = 14/30 (46%), Positives = 18/30 (60%)
Query: 1146 DAFRCDEGLCIAARFVCDGRPQCADGSDEA 1175
+ F+C C++A CDG C DGSDEA
Sbjct: 143 EEFQCLNHRCVSAVQRCDGVDACGDGSDEA 172
>X55077-1|CAA38905.1| 591|Homo sapiens alpha-2 macroglobulin
receptor protein.
Length = 591
Score = 56.0 bits (129), Expect = 8e-07
Identities = 27/57 (47%), Positives = 34/57 (59%), Gaps = 2/57 (3%)
Query: 240 PADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSST 296
P D+ V+ RQ ++PCK NN GCS+LCLLSP G+ CACPT L + T
Sbjct: 1 PMDLHVFHALRQP-DVPNHPCKVNNGGCSNLCLLSPG-GGHKCACPTNFYLGSDGRT 55
Score = 53.2 bits (122), Expect = 5e-06
Identities = 24/57 (42%), Positives = 36/57 (63%), Gaps = 5/57 (8%)
Query: 852 DLKLYH--RAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
DL ++H R + ++ C V+NGGCS+LCL +PG ++CACP ++ L D TC
Sbjct: 3 DLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPGG---GHKCACPTNFYLGSDGRTC 56
Score = 50.8 bits (116), Expect = 3e-05
Identities = 33/100 (33%), Positives = 38/100 (38%), Gaps = 16/100 (16%)
Query: 1096 QCDGQQDCEDGRDEAECGA---------CGGDVRC------ADGTXXXXXXXXXXXXXXX 1140
+C+GQ +C DG DE +C C RC D
Sbjct: 158 RCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQ 217
Query: 1141 XXXXXDAFRC-DEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
D FRC D G CI AR+ CDG C DGSDE C
Sbjct: 218 MTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEEC 257
Score = 48.0 bits (109), Expect = 2e-04
Identities = 30/99 (30%), Positives = 35/99 (35%), Gaps = 14/99 (14%)
Query: 1096 QCDGQQDCEDGRDEAECGA-CGGDV-------------RCADGTXXXXXXXXXXXXXXXX 1141
+CDG DC DG DE +C C D RC
Sbjct: 319 KCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVR 378
Query: 1142 XXXXDAFRCDEGLCIAARFVCDGRPQCADGSDEAPAACA 1180
D F+C+ LC + CDG C D SDE P CA
Sbjct: 379 TCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECA 417
Score = 43.6 bits (98), Expect = 0.004
Identities = 32/95 (33%), Positives = 36/95 (37%), Gaps = 17/95 (17%)
Query: 1096 QCDGQQDCEDGRDEA--ECGA---------CGGDVRCADGTXXXXXXXXXXXXXXXXXXX 1144
+CDG+ DC DG DE EC C + RC G
Sbjct: 239 KCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNN-RCVPGRWQCDYDNDCGDNSDEESCT 297
Query: 1145 -----XDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
F C G CIA R+ CDG CADGSDE
Sbjct: 298 PRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDE 332
Score = 43.2 bits (97), Expect = 0.006
Identities = 18/40 (45%), Positives = 24/40 (60%), Gaps = 1/40 (2%)
Query: 566 NPCADDNGGCSHLCFNRP-DDYICGCPLGLELTADKKTCV 604
+PC +NGGCS+LC P + C CP L +D +TCV
Sbjct: 18 HPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCV 57
Score = 38.7 bits (86), Expect = 0.12
Identities = 14/28 (50%), Positives = 17/28 (60%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEA 1175
F+C G+C F+CDG C D SDEA
Sbjct: 105 FQCSTGICTNPAFICDGDNDCQDNSDEA 132
Score = 34.7 bits (76), Expect = 2.0
Identities = 32/113 (28%), Positives = 36/113 (31%), Gaps = 20/113 (17%)
Query: 1097 CDGQQDCEDGRDE-AECG--ACGGD-VRCADGTXXXXXXXXXXXXXXXXXXXXDA----- 1147
CD DC DG DE A C CG D RC D +
Sbjct: 199 CDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECD 258
Query: 1148 --------FRCDEGLCIAARFVCDGRPQCADGSDE---APAACAYGHTDQVNG 1189
FRC C+ R+ CD C D SDE P C+ NG
Sbjct: 259 ERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANG 311
Score = 33.5 bits (73), Expect = 4.7
Identities = 11/20 (55%), Positives = 14/20 (70%)
Query: 1093 VSRQCDGQQDCEDGRDEAEC 1112
+ RQCDG +C DG DE +C
Sbjct: 438 IGRQCDGTDNCGDGTDEEDC 457
>BC088378-1|AAH88378.1| 377|Homo sapiens LRP10 protein protein.
Length = 377
Score = 54.4 bits (125), Expect = 2e-06
Identities = 33/94 (35%), Positives = 39/94 (41%), Gaps = 15/94 (15%)
Query: 1096 QCDGQQDCEDGRDEAECGACG-GDVRC-ADGTXXXXXXXXXXXXXXXXXXXXDA------ 1147
+CDG DC DG DE +C C G C A GT D
Sbjct: 1 RCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATACYLPADRCNYQTFCADGADERRC 60
Query: 1148 -------FRCDEGLCIAARFVCDGRPQCADGSDE 1174
FRC + C+ +VCDG+P CADGSDE
Sbjct: 61 RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDE 94
>AB208822-1|BAD92059.1| 555|Homo sapiens Very low-density lipoprotein
receptor precursor variant protein.
Length = 555
Score = 53.2 bits (122), Expect = 5e-06
Identities = 32/90 (35%), Positives = 42/90 (46%), Gaps = 29/90 (32%)
Query: 1093 VSRQCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDE 1152
VS +CDG+ DC+ G DE CG ++ C+ D F C
Sbjct: 187 VSWRCDGENDCDSGEDEENCG----NITCSP----------------------DEFTCSS 220
Query: 1153 GLCIAARFVCDGRPQCADGSDE---APAAC 1179
G CI+ FVC+G+ C+DGSDE AP C
Sbjct: 221 GRCISRNFVCNGQDDCSDGSDELDCAPPTC 250
Score = 52.8 bits (121), Expect = 7e-06
Identities = 36/126 (28%), Positives = 49/126 (38%), Gaps = 8/126 (6%)
Query: 1054 GRGAIMRANVDGTGRVELARADNATALALDQSAGTVYWAVSRQCDGQQDCEDGRDEAECG 1113
G G ++A GT + A A +S T ++ Q C +GR
Sbjct: 48 GGGGTIQAGTMGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLW 107
Query: 1114 ACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSD 1173
C GD C DG+ F C+ G C+ +R+ CDG P C DGSD
Sbjct: 108 KCDGDEDCVDGSDEKNCVKKTCAESD--------FVCNNGQCVPSRWKCDGDPDCEDGSD 159
Query: 1174 EAPAAC 1179
E+P C
Sbjct: 160 ESPEQC 165
Score = 44.4 bits (100), Expect = 0.002
Identities = 19/38 (50%), Positives = 23/38 (60%), Gaps = 1/38 (2%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
N C +NGGCSH+C + Y C C G EL D+KTC
Sbjct: 415 NECLVNNGGCSHICKDLVIGYECDCAAGFEL-IDRKTC 451
Score = 44.4 bits (100), Expect = 0.002
Identities = 24/92 (26%), Positives = 43/92 (46%), Gaps = 4/92 (4%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTC--VEPEAFLVYSRKNIIGRLSIKNEYNDA 630
G CS +C N Y C C G ++ C V E L+++ + I ++ + E +
Sbjct: 461 GICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGL--ERKEY 518
Query: 631 VIPIKDLKEVSALALYVSGSKLYWSDSKTKTI 662
+ ++ L+ AL ++ KL+W+D K I
Sbjct: 519 IQLVEQLRNTVALDADIAAQKLFWADLSQKAI 550
Score = 43.6 bits (98), Expect = 0.004
Identities = 30/99 (30%), Positives = 38/99 (38%), Gaps = 22/99 (22%)
Query: 1097 CDGQQDCEDGRDEAEC-----GA----------------CGGDVRCADGTXXXXXXXXXX 1135
C+GQ DC DG DE +C GA C D C+D +
Sbjct: 230 CNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQ 289
Query: 1136 XXXXXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
+ +C G CI ++ CDG P C DGSDE
Sbjct: 290 PVIHTKCPASE-IQCGSGECIHKKWRCDGDPDCKDGSDE 327
Score = 40.7 bits (91), Expect = 0.031
Identities = 20/47 (42%), Positives = 27/47 (57%), Gaps = 5/47 (10%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
N+C V+NGGCSH+C D+ Y C C A + L D TC + +E
Sbjct: 415 NECLVNNGGCSHIC----KDLVIGYECDCAAGFEL-IDRKTCGDIDE 456
Score = 37.5 bits (83), Expect = 0.29
Identities = 28/99 (28%), Positives = 34/99 (34%), Gaps = 15/99 (15%)
Query: 1096 QCDGQQDCEDGRDEAECGA--CGGD-VRCADGTXXXXXXXXXXXXXXXXXXXX------- 1145
+CDG DC+DG DE C + C D C DG+
Sbjct: 314 RCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVN 373
Query: 1146 -----DAFRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F+C G CI VC+ C D SDE C
Sbjct: 374 QCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKEC 412
Score = 35.9 bits (79), Expect = 0.87
Identities = 29/118 (24%), Positives = 52/118 (44%), Gaps = 12/118 (10%)
Query: 846 DLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNIT 905
+ D + +L R ++C + G CS +C+ G Y+C C Y+++
Sbjct: 436 ECDCAAGFELIDRKTCGDIDECQ-NPGICSQICINLKGG----YKCECSRGYQMDLATGV 490
Query: 906 CSE--PEEFLLFAQKNAVGRIMVANGECNDAYIPLTG-LKNVRAIEYDPVEKQLYWMD 960
C E L+F + + +I + E YI L L+N A++ D ++L+W D
Sbjct: 491 CKAVGKEPSLIFTNRRDIRKIGLERKE----YIQLVEQLRNTVALDADIAAQKLFWAD 544
Score = 33.5 bits (73), Expect = 4.7
Identities = 17/41 (41%), Positives = 20/41 (48%), Gaps = 4/41 (9%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYD 300
C NN GCSH+C GY C C G +L + TC D
Sbjct: 417 CLVNNGGCSHIC--KDLVIGYECDCAAGFELIDRK--TCGD 453
Score = 33.1 bits (72), Expect = 6.2
Identities = 12/19 (63%), Positives = 14/19 (73%)
Query: 1094 SRQCDGQQDCEDGRDEAEC 1112
SRQC+G +DC DG DE C
Sbjct: 351 SRQCNGIRDCVDGSDEVNC 369
>AL450467-1|CAH72452.1| 173|Homo sapiens very low density lipoprotein
receptor protein.
Length = 173
Score = 52.4 bits (120), Expect = 9e-06
Identities = 28/85 (32%), Positives = 37/85 (43%), Gaps = 9/85 (10%)
Query: 1096 QCDGQQ-DCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGL 1154
+C+ Q C +GR C GD C DG+ F C+ G
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESD--------FVCNNGQ 83
Query: 1155 CIAARFVCDGRPQCADGSDEAPAAC 1179
C+ +R+ CDG P C DGSDE+P C
Sbjct: 84 CVPSRWKCDGDPDCEDGSDESPEQC 108
Score = 51.6 bits (118), Expect = 2e-05
Identities = 42/139 (30%), Positives = 54/139 (38%), Gaps = 36/139 (25%)
Query: 1065 GTGRVELARADNATALALDQSAGTVYWAVSRQCDGQQDCEDGRDEAEC------------ 1112
GTGR A+ + + + T+ W +CDG +DC DG DE C
Sbjct: 26 GTGRK--AKCEPSQFQCTNGRCITLLW----KCDGDEDCVDGSDEKNCVKKTCAESDFVC 79
Query: 1113 ---------GACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEGLCIAARFVCD 1163
C GD C DG+ D F C G CI+ FVC+
Sbjct: 80 NNGQCVPSRWKCDGDPDCEDGSDESPEQCRNITCSP------DEFTCSSGRCISRNFVCN 133
Query: 1164 GRPQCADGSDE---APAAC 1179
G+ C+DGSDE AP C
Sbjct: 134 GQDDCSDGSDELDCAPPTC 152
Score = 32.7 bits (71), Expect = 8.1
Identities = 13/29 (44%), Positives = 18/29 (62%), Gaps = 3/29 (10%)
Query: 1097 CDGQQDCEDGRDEAECG--ACGG-DVRCA 1122
C+GQ DC DG DE +C CG + +C+
Sbjct: 132 CNGQDDCSDGSDELDCAPPTCGAHEFQCS 160
>AC068287-1|AAY24318.1| 223|Homo sapiens unknown protein.
Length = 223
Score = 52.0 bits (119), Expect = 1e-05
Identities = 47/177 (26%), Positives = 72/177 (40%), Gaps = 15/177 (8%)
Query: 573 GGCSHLCFNRPDDYICGCPLGLELTADKKTC---VEPE---AFLVYSRKNIIGRLSIKNE 626
G CS C N Y C C G + D ++C +EP L+ + I + N
Sbjct: 48 GTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETI-EVFYLNG 106
Query: 627 YNDAVIPIKDLKEVSALALYVSGSKLYWSDSKT-----KTINRCSVNGSAVE---KIVEW 678
A + + E+ L + + W +S+ K I G E I++
Sbjct: 107 SKMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQS 166
Query: 679 LGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKG 735
V+ +AIDW +N+Y+ D RI V +GS +I L PK+I +DP G
Sbjct: 167 FHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAG 223
Score = 45.6 bits (103), Expect = 0.001
Identities = 49/178 (27%), Positives = 78/178 (43%), Gaps = 16/178 (8%)
Query: 267 CSHLCLLSPDPPGYNCACPTGVKLR-ENSSTTCYDSPQ---MLLVVAQRSTISKISLDSP 322
CS C + Y C+C G ++ +N S P +L++A TI L+
Sbjct: 50 CSQTCRNTHG--SYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGS 107
Query: 323 DFTPYTLPLKDLKRTLTVDFDPKTEYIYWADGLA-----KTISKARLDG-SDQSVV--VR 374
TL + T+DF + I W + K I + G +D+ + ++
Sbjct: 108 KMA--TLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQ 165
Query: 375 SSGVPDSIAIDPLSRKIYWTDPVMDTINVARLDGSYEKVIIHTELYDPRAIALHLTAG 432
S +AID L+R +Y+ D V D I V +GS +I EL++P+AIA+ AG
Sbjct: 166 SFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAG 223
Score = 37.1 bits (82), Expect = 0.38
Identities = 28/101 (27%), Positives = 46/101 (45%), Gaps = 4/101 (3%)
Query: 23 VDFHYRKNLICW--SDQKPELIQCMNYNET--YTGEKFKIVSEGLVTPTGIAIDWYTDKL 78
+DF Y +++ICW S + ++C+ + T E + + +AIDW T L
Sbjct: 123 LDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNL 182
Query: 79 YWTDGETNKIEVISIVQKYRKVLFWSEVDLARAIAVVPEDG 119
Y+ D ++I V + L E+ +AIAV P G
Sbjct: 183 YFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAG 223
Score = 33.5 bits (73), Expect = 4.7
Identities = 32/150 (21%), Positives = 57/150 (38%), Gaps = 15/150 (10%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS---EPEE---FLLFAQK 918
++C V G CS C T G Y C+C Y + DN +C EP + LL A
Sbjct: 42 DECAV-YGTCSQTCRNTHGS----YTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANF 96
Query: 919 NAVGRIMVANGECNDAYIPLTGLKNVRAIEYDPVEKQLYWMD--DDSHSIRRVPISYXXX 976
+ + NG + G + +++ E + W++ + S+ ++ + I+
Sbjct: 97 ETI-EVFYLNGSKMATLSSVNG-NEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGG 154
Query: 977 XXXXXXXXXXXGLSRPYHMVLDVLGRTMYW 1006
M +D L R +Y+
Sbjct: 155 LTDEWTINILQSFHNVQQMAIDWLTRNLYF 184
>L13720-1|AAA58494.1| 678|Homo sapiens growth-arrest-specific
protein protein.
Length = 678
Score = 51.2 bits (117), Expect = 2e-05
Identities = 17/38 (44%), Positives = 25/38 (65%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
N C+ +NGGC +C N+P + C C G EL++D +TC
Sbjct: 158 NECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTC 195
Score = 41.5 bits (93), Expect = 0.018
Identities = 16/47 (34%), Positives = 26/47 (55%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
N+C +NGGC +C PG + C+C + + L+ D TC + +E
Sbjct: 158 NECSQENGGCLQICHNKPG----SFHCSCHSGFELSSDGRTCQDIDE 200
>BX072579-3|CAH71174.1| 678|Homo sapiens growth arrest-specific 6
protein.
Length = 678
Score = 51.2 bits (117), Expect = 2e-05
Identities = 17/38 (44%), Positives = 25/38 (65%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
N C+ +NGGC +C N+P + C C G EL++D +TC
Sbjct: 158 NECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTC 195
Score = 41.5 bits (93), Expect = 0.018
Identities = 16/47 (34%), Positives = 26/47 (55%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
N+C +NGGC +C PG + C+C + + L+ D TC + +E
Sbjct: 158 NECSQENGGCLQICHNKPG----SFHCSCHSGFELSSDGRTCQDIDE 200
>BC038984-1|AAH38984.1| 678|Homo sapiens growth arrest-specific 6
protein.
Length = 678
Score = 51.2 bits (117), Expect = 2e-05
Identities = 17/38 (44%), Positives = 25/38 (65%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
N C+ +NGGC +C N+P + C C G EL++D +TC
Sbjct: 158 NECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTC 195
Score = 41.5 bits (93), Expect = 0.018
Identities = 16/47 (34%), Positives = 26/47 (55%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
N+C +NGGC +C PG + C+C + + L+ D TC + +E
Sbjct: 158 NECSQENGGCLQICHNKPG----SFHCSCHSGFELSSDGRTCQDIDE 200
>AY256843-1|AAO84057.1| 678|Homo sapiens growth arrested-specific 6
protein.
Length = 678
Score = 51.2 bits (117), Expect = 2e-05
Identities = 17/38 (44%), Positives = 25/38 (65%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
N C+ +NGGC +C N+P + C C G EL++D +TC
Sbjct: 158 NECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTC 195
Score = 41.5 bits (93), Expect = 0.018
Identities = 16/47 (34%), Positives = 26/47 (55%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
N+C +NGGC +C PG + C+C + + L+ D TC + +E
Sbjct: 158 NECSQENGGCLQICHNKPG----SFHCSCHSGFELSSDGRTCQDIDE 200
>AK126533-1|BAC86580.1| 624|Homo sapiens protein ( Homo sapiens
cDNA FLJ44569 fis, clone UTERU3009979, highly similar
to Homo sapiens growth arrest-specific 6 (GAS6). ).
Length = 624
Score = 51.2 bits (117), Expect = 2e-05
Identities = 17/38 (44%), Positives = 25/38 (65%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
N C+ +NGGC +C N+P + C C G EL++D +TC
Sbjct: 104 NECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTC 141
Score = 41.5 bits (93), Expect = 0.018
Identities = 16/47 (34%), Positives = 26/47 (55%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
N+C +NGGC +C PG + C+C + + L+ D TC + +E
Sbjct: 104 NECSQENGGCLQICHNKPG----SFHCSCHSGFELSSDGRTCQDIDE 146
>AB111888-1|BAC98376.1| 1322|Homo sapiens KIAA2036 protein protein.
Length = 1322
Score = 51.2 bits (117), Expect = 2e-05
Identities = 32/107 (29%), Positives = 41/107 (38%), Gaps = 14/107 (13%)
Query: 1097 CDGQQDCEDGRDEAECGA--CG-GDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEG 1153
CD Q DC DG DE C A CG G + C+ G ++ C +G
Sbjct: 282 CDNQDDCGDGSDEEGCAAPGCGEGQMTCSSGHCLPLALLCDRQDDCGDGTDEPSYPCPQG 341
Query: 1154 L-------CIAARFVCDGRPQCADGSDE----APAACAYGHTDQVNG 1189
L C+ +CDG P C D +DE C G V+G
Sbjct: 342 LLACADGRCLPPALLCDGHPDCLDAADEESCLGQVTCVPGEVSCVDG 388
Score = 44.0 bits (99), Expect = 0.003
Identities = 28/94 (29%), Positives = 35/94 (37%), Gaps = 11/94 (11%)
Query: 1097 CDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDA--------- 1147
CD Q DC DG DE G + CADG ++
Sbjct: 321 CDRQDDCGDGTDEPSYPCPQGLLACADGRCLPPALLCDGHPDCLDAADEESCLGQVTCVP 380
Query: 1148 --FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
C +G C+ A +CDG C DG+DE P C
Sbjct: 381 GEVSCVDGTCLGAIQLCDGVWDCPDGADEGPGHC 414
Score = 37.9 bits (84), Expect = 0.22
Identities = 14/25 (56%), Positives = 17/25 (68%)
Query: 1155 CIAARFVCDGRPQCADGSDEAPAAC 1179
C++ +CDG QC DGSDE P AC
Sbjct: 502 CVSPEQLCDGVRQCPDGSDEGPDAC 526
Score = 37.5 bits (83), Expect = 0.29
Identities = 19/46 (41%), Positives = 20/46 (43%), Gaps = 2/46 (4%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDE--APAACAYGHTDQVNGIH 1191
FRC G C + CD CADGSDE CA H G H
Sbjct: 456 FRCGSGECTPRGWRCDQEEDCADGSDERGCGGPCAPHHAPCARGPH 501
>AF117899-1|AAF27280.1| 363|Homo sapiens LDLR-FUT fusion protein
protein.
Length = 363
Score = 50.8 bits (116), Expect = 3e-05
Identities = 31/97 (31%), Positives = 38/97 (39%), Gaps = 13/97 (13%)
Query: 1096 QCDGQQDCEDGRDEAECG--ACGGD-VRCADGTXXXXXXXXXXXXXXXXXXXXDA----- 1147
+CDGQ DC++G DE C C D RC DG +
Sbjct: 88 RCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLI 147
Query: 1148 -----FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F+C+ CI + CD P C DGSDE P C
Sbjct: 148 CGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRC 184
Score = 50.0 bits (114), Expect = 5e-05
Identities = 35/97 (36%), Positives = 43/97 (44%), Gaps = 19/97 (19%)
Query: 1097 CDGQQDCEDGRDEAE-------CGA----CGGDV-RC------ADGTXXXXXXXXXXXXX 1138
CDG +C+DG DE++ C + CGG V RC DG
Sbjct: 46 CDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCP 105
Query: 1139 XXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDEA 1175
D FRC +G CI+ +FVCD C DGSDEA
Sbjct: 106 PKTCSQ-DEFRCHDGKCISRQFVCDSDRDCLDGSDEA 141
Score = 46.4 bits (105), Expect = 6e-04
Identities = 16/32 (50%), Positives = 23/32 (71%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F+C +G CI+ ++VCDG +C DGSDE+ C
Sbjct: 32 FQCQDGKCISYKWVCDGSAECQDGSDESQETC 63
Score = 41.5 bits (93), Expect = 0.018
Identities = 34/107 (31%), Positives = 39/107 (36%), Gaps = 25/107 (23%)
Query: 1093 VSRQ--CDGQQDCEDGRDEAECG---------------------ACGGDVRCADGTXXXX 1129
+SRQ CD +DC DG DEA C AC D C DG+
Sbjct: 122 ISRQFVCDSDRDCLDGSDEASCPVLICGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWP 181
Query: 1130 XXXXXXXXXXXXXXXXDAFR--CDEGLCIAARFVCDGRPQCADGSDE 1174
AF C G CI + + CDG P C D SDE
Sbjct: 182 QRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDE 228
Score = 34.7 bits (76), Expect = 2.0
Identities = 28/100 (28%), Positives = 40/100 (40%), Gaps = 12/100 (12%)
Query: 1078 TALALDQSAGTVYWAVSRQCDGQQ-DCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXX 1136
T L +AGT AV +C+ + C+DG+ + C G C DG+
Sbjct: 11 TVALLLAAAGT---AVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVT 67
Query: 1137 XXXXXXXXXDAFRCDEGL--CIAARFVCDGRPQCADGSDE 1174
F C + CI + CDG+ C +GSDE
Sbjct: 68 CKSGD------FSCGGRVNRCIPQFWRCDGQVDCDNGSDE 101
>BC110451-1|AAI10452.1| 1042|Homo sapiens corin, serine peptidase
protein.
Length = 1042
Score = 49.6 bits (113), Expect = 7e-05
Identities = 33/109 (30%), Positives = 40/109 (36%), Gaps = 9/109 (8%)
Query: 1096 QCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXD--------A 1147
QC+G DC+D DEA C C G
Sbjct: 288 QCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTTE 347
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC-AYGHTDQVNGIHPPLT 1195
RC +G CIA +VCDG C D SDE +C + G + NG P T
Sbjct: 348 HRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVECRNGQCIPST 396
Score = 46.0 bits (104), Expect = 8e-04
Identities = 27/91 (29%), Positives = 34/91 (37%), Gaps = 10/91 (10%)
Query: 1094 SRQCDGQQDCEDGRDEAECGA-------CGGDVRCADGTXXXXXX---XXXXXXXXXXXX 1143
SR+CDGQ DC+D DE CG C + +C T
Sbjct: 596 SRRCDGQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSFC 655
Query: 1144 XXDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
D C C++ CDG C+D SDE
Sbjct: 656 QDDELECANHACVSRDLWCDGEADCSDSSDE 686
Score = 40.7 bits (91), Expect = 0.031
Identities = 28/88 (31%), Positives = 29/88 (32%), Gaps = 11/88 (12%)
Query: 1097 CDGQQDCEDGRDEAECGACGGDV--RCADGTXXXXXXX--------XXXXXXXXXXXXXD 1146
CDG DC D DE C C RC DG
Sbjct: 325 CDGYDDCGDLSDEQNCD-CNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQG 383
Query: 1147 AFRCDEGLCIAARFVCDGRPQCADGSDE 1174
C G CI + F CDG C DGSDE
Sbjct: 384 LVECRNGQCIPSTFQCDGDEDCKDGSDE 411
Score = 36.7 bits (81), Expect = 0.50
Identities = 14/32 (43%), Positives = 17/32 (53%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F+C G C+ A CDG+ C D SDE C
Sbjct: 585 FKCRSGQCVLASRRCDGQADCDDDSDEENCGC 616
Score = 35.9 bits (79), Expect = 0.87
Identities = 14/33 (42%), Positives = 18/33 (54%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAACA 1180
F C G+CI + C+G C D SDEA C+
Sbjct: 275 FLCASGICIPGKLQCNGYNDCDDWSDEAHCNCS 307
Score = 35.5 bits (78), Expect = 1.2
Identities = 16/31 (51%), Positives = 19/31 (61%), Gaps = 5/31 (16%)
Query: 1096 QCDGQQDCEDGRDEAECG----AC-GGDVRC 1121
QCDG +DC+DG DE C +C GD RC
Sbjct: 398 QCDGDEDCKDGSDEENCSVIQTSCQEGDQRC 428
>AF133845-1|AAD31850.1| 1042|Homo sapiens corin protein.
Length = 1042
Score = 49.6 bits (113), Expect = 7e-05
Identities = 33/109 (30%), Positives = 40/109 (36%), Gaps = 9/109 (8%)
Query: 1096 QCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXD--------A 1147
QC+G DC+D DEA C C G
Sbjct: 288 QCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTTE 347
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC-AYGHTDQVNGIHPPLT 1195
RC +G CIA +VCDG C D SDE +C + G + NG P T
Sbjct: 348 HRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVECRNGQCIPST 396
Score = 46.0 bits (104), Expect = 8e-04
Identities = 27/91 (29%), Positives = 34/91 (37%), Gaps = 10/91 (10%)
Query: 1094 SRQCDGQQDCEDGRDEAECGA-------CGGDVRCADGTXXXXXX---XXXXXXXXXXXX 1143
SR+CDGQ DC+D DE CG C + +C T
Sbjct: 596 SRRCDGQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSFC 655
Query: 1144 XXDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
D C C++ CDG C+D SDE
Sbjct: 656 QDDELECANHACVSRDLWCDGEADCSDSSDE 686
Score = 40.7 bits (91), Expect = 0.031
Identities = 28/88 (31%), Positives = 29/88 (32%), Gaps = 11/88 (12%)
Query: 1097 CDGQQDCEDGRDEAECGACGGDV--RCADGTXXXXXXX--------XXXXXXXXXXXXXD 1146
CDG DC D DE C C RC DG
Sbjct: 325 CDGYDDCGDLSDEQNCD-CNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQG 383
Query: 1147 AFRCDEGLCIAARFVCDGRPQCADGSDE 1174
C G CI + F CDG C DGSDE
Sbjct: 384 LVECRNGQCIPSTFQCDGDEDCKDGSDE 411
Score = 36.7 bits (81), Expect = 0.50
Identities = 14/32 (43%), Positives = 17/32 (53%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAAC 1179
F+C G C+ A CDG+ C D SDE C
Sbjct: 585 FKCRSGQCVLASRRCDGQADCDDDSDEENCGC 616
Score = 35.9 bits (79), Expect = 0.87
Identities = 14/33 (42%), Positives = 18/33 (54%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAACA 1180
F C G+CI + C+G C D SDEA C+
Sbjct: 275 FLCASGICIPGKLQCNGYNDCDDWSDEAHCNCS 307
Score = 35.5 bits (78), Expect = 1.2
Identities = 16/31 (51%), Positives = 19/31 (61%), Gaps = 5/31 (16%)
Query: 1096 QCDGQQDCEDGRDEAECG----AC-GGDVRC 1121
QCDG +DC+DG DE C +C GD RC
Sbjct: 398 QCDGDEDCKDGSDEENCSVIQTSCQEGDQRC 428
>AL513320-1|CAI14334.1| 1229|Homo sapiens multiple EGF-like-domains
6 protein.
Length = 1229
Score = 48.8 bits (111), Expect = 1e-04
Identities = 18/40 (45%), Positives = 25/40 (62%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
N C +NGGCSH C + +C CP G EL D++TC++
Sbjct: 228 NSCEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCID 267
Score = 48.4 bits (110), Expect = 2e-04
Identities = 17/37 (45%), Positives = 20/37 (54%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
C NGGC H C N P Y+C C G L D +TC+
Sbjct: 60 CRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCL 96
Score = 44.0 bits (99), Expect = 0.003
Identities = 18/42 (42%), Positives = 24/42 (57%), Gaps = 4/42 (9%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
++C NGGC H C+ TPG Y C C +RL+ D+ TC
Sbjct: 58 DECRTHNGGCQHRCVNTPG----SYLCECKPGFRLHTDSRTC 95
Score = 40.7 bits (91), Expect = 0.031
Identities = 18/47 (38%), Positives = 25/47 (53%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
++C GGC H C G ++C+C A YRL++D CS EE
Sbjct: 309 DECASSRGGCEHHCTNLAGS----FQCSCEAGYRLHEDRRGCSPLEE 351
Score = 39.9 bits (89), Expect = 0.054
Identities = 23/77 (29%), Positives = 34/77 (44%), Gaps = 4/77 (5%)
Query: 835 TDGSNRKSIRKDLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACP 894
T GS + + +D + +R + N C +NGGCSH C T C CP
Sbjct: 198 TQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGP----LCTCP 253
Query: 895 AHYRLNKDNITCSEPEE 911
Y L+ D TC + ++
Sbjct: 254 RGYELDTDQRTCIDVDD 270
Score = 39.1 bits (87), Expect = 0.094
Identities = 14/36 (38%), Positives = 17/36 (47%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA GGC H C N + C C G L D++ C
Sbjct: 311 CASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGC 346
Score = 37.1 bits (82), Expect = 0.38
Identities = 16/38 (42%), Positives = 20/38 (52%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
+PCA+ NG C H C C C +G +L AD K C
Sbjct: 141 SPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKAC 178
Score = 37.1 bits (82), Expect = 0.38
Identities = 18/41 (43%), Positives = 21/41 (51%), Gaps = 3/41 (7%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYD 300
C+ NN GCSH C S G C CP G +L + TC D
Sbjct: 230 CEANNGGCSHGC--SHTSAGPLCTCPRGYEL-DTDQRTCID 267
Score = 35.5 bits (78), Expect = 1.2
Identities = 15/42 (35%), Positives = 21/42 (50%), Gaps = 3/42 (7%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
N C + NGGC H C+ T +RC C ++L +D C
Sbjct: 99 NSCALGNGGCQHHCVQL---TITRHRCQCRPGFQLQEDGRHC 137
Score = 35.5 bits (78), Expect = 1.2
Identities = 17/46 (36%), Positives = 21/46 (45%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYS 613
CA C+H C N + C C G EL AD + C E +V S
Sbjct: 184 CAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNS 229
Score = 35.5 bits (78), Expect = 1.2
Identities = 16/36 (44%), Positives = 19/36 (52%), Gaps = 1/36 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CAD + C +C N P Y CGC G L+AD C
Sbjct: 271 CAD-SPCCQQVCTNNPGGYECGCYAGYRLSADGCGC 305
Score = 35.1 bits (77), Expect = 1.5
Identities = 14/37 (37%), Positives = 20/37 (54%), Gaps = 2/37 (5%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSST 296
C+ +N GC H C+ +P Y C C G +L +S T
Sbjct: 60 CRTHNGGCQHRCVNTPG--SYLCECKPGFRLHTDSRT 94
Score = 33.9 bits (74), Expect = 3.5
Identities = 17/43 (39%), Positives = 20/43 (46%), Gaps = 1/43 (2%)
Query: 563 LGWNPCADDNGGCSHLCFNRP-DDYICGCPLGLELTADKKTCV 604
L N CA NGGC H C + C C G +L D + CV
Sbjct: 96 LAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCV 138
Score = 33.1 bits (72), Expect = 6.2
Identities = 15/42 (35%), Positives = 20/42 (47%), Gaps = 4/42 (9%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
D+ C +C PG Y C C A YRL+ D C + +E
Sbjct: 273 DSPCCQQVCTNNPGG----YECGCYAGYRLSADGCGCEDVDE 310
>AL512413-3|CAH70834.1| 1229|Homo sapiens multiple EGF-like-domains
6 protein.
Length = 1229
Score = 48.8 bits (111), Expect = 1e-04
Identities = 18/40 (45%), Positives = 25/40 (62%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
N C +NGGCSH C + +C CP G EL D++TC++
Sbjct: 228 NSCEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCID 267
Score = 48.4 bits (110), Expect = 2e-04
Identities = 17/37 (45%), Positives = 20/37 (54%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
C NGGC H C N P Y+C C G L D +TC+
Sbjct: 60 CRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCL 96
Score = 44.0 bits (99), Expect = 0.003
Identities = 18/42 (42%), Positives = 24/42 (57%), Gaps = 4/42 (9%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
++C NGGC H C+ TPG Y C C +RL+ D+ TC
Sbjct: 58 DECRTHNGGCQHRCVNTPG----SYLCECKPGFRLHTDSRTC 95
Score = 40.7 bits (91), Expect = 0.031
Identities = 18/47 (38%), Positives = 25/47 (53%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
++C GGC H C G ++C+C A YRL++D CS EE
Sbjct: 309 DECASSRGGCEHHCTNLAGS----FQCSCEAGYRLHEDRRGCSPLEE 351
Score = 39.9 bits (89), Expect = 0.054
Identities = 23/77 (29%), Positives = 34/77 (44%), Gaps = 4/77 (5%)
Query: 835 TDGSNRKSIRKDLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACP 894
T GS + + +D + +R + N C +NGGCSH C T C CP
Sbjct: 198 TQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGP----LCTCP 253
Query: 895 AHYRLNKDNITCSEPEE 911
Y L+ D TC + ++
Sbjct: 254 RGYELDTDQRTCIDVDD 270
Score = 39.1 bits (87), Expect = 0.094
Identities = 14/36 (38%), Positives = 17/36 (47%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA GGC H C N + C C G L D++ C
Sbjct: 311 CASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGC 346
Score = 37.1 bits (82), Expect = 0.38
Identities = 16/38 (42%), Positives = 20/38 (52%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
+PCA+ NG C H C C C +G +L AD K C
Sbjct: 141 SPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKAC 178
Score = 37.1 bits (82), Expect = 0.38
Identities = 18/41 (43%), Positives = 21/41 (51%), Gaps = 3/41 (7%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYD 300
C+ NN GCSH C S G C CP G +L + TC D
Sbjct: 230 CEANNGGCSHGC--SHTSAGPLCTCPRGYEL-DTDQRTCID 267
Score = 35.5 bits (78), Expect = 1.2
Identities = 15/42 (35%), Positives = 21/42 (50%), Gaps = 3/42 (7%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
N C + NGGC H C+ T +RC C ++L +D C
Sbjct: 99 NSCALGNGGCQHHCVQL---TITRHRCQCRPGFQLQEDGRHC 137
Score = 35.5 bits (78), Expect = 1.2
Identities = 17/46 (36%), Positives = 21/46 (45%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYS 613
CA C+H C N + C C G EL AD + C E +V S
Sbjct: 184 CAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNS 229
Score = 35.5 bits (78), Expect = 1.2
Identities = 16/36 (44%), Positives = 19/36 (52%), Gaps = 1/36 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CAD + C +C N P Y CGC G L+AD C
Sbjct: 271 CAD-SPCCQQVCTNNPGGYECGCYAGYRLSADGCGC 305
Score = 35.1 bits (77), Expect = 1.5
Identities = 14/37 (37%), Positives = 20/37 (54%), Gaps = 2/37 (5%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSST 296
C+ +N GC H C+ +P Y C C G +L +S T
Sbjct: 60 CRTHNGGCQHRCVNTPG--SYLCECKPGFRLHTDSRT 94
Score = 33.9 bits (74), Expect = 3.5
Identities = 17/43 (39%), Positives = 20/43 (46%), Gaps = 1/43 (2%)
Query: 563 LGWNPCADDNGGCSHLCFNRP-DDYICGCPLGLELTADKKTCV 604
L N CA NGGC H C + C C G +L D + CV
Sbjct: 96 LAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCV 138
Score = 33.1 bits (72), Expect = 6.2
Identities = 15/42 (35%), Positives = 20/42 (47%), Gaps = 4/42 (9%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
D+ C +C PG Y C C A YRL+ D C + +E
Sbjct: 273 DSPCCQQVCTNNPGG----YECGCYAGYRLSADGCGCEDVDE 310
>AB231860-1|BAE19678.1| 1640|Homo sapiens hypothetical protein
protein.
Length = 1640
Score = 48.8 bits (111), Expect = 1e-04
Identities = 18/40 (45%), Positives = 25/40 (62%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
N C +NGGCSH C + +C CP G EL D++TC++
Sbjct: 408 NSCEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCID 447
Score = 48.4 bits (110), Expect = 2e-04
Identities = 17/37 (45%), Positives = 20/37 (54%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
C NGGC H C N P Y+C C G L D +TC+
Sbjct: 240 CRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCL 276
Score = 44.0 bits (99), Expect = 0.003
Identities = 18/42 (42%), Positives = 24/42 (57%), Gaps = 4/42 (9%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
++C NGGC H C+ TPG Y C C +RL+ D+ TC
Sbjct: 238 DECRTHNGGCQHRCVNTPG----SYLCECKPGFRLHTDSRTC 275
Score = 40.7 bits (91), Expect = 0.031
Identities = 18/47 (38%), Positives = 25/47 (53%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
++C GGC H C G ++C+C A YRL++D CS EE
Sbjct: 489 DECASSRGGCEHHCTNLAGS----FQCSCEAGYRLHEDRRGCSPLEE 531
Score = 39.9 bits (89), Expect = 0.054
Identities = 23/77 (29%), Positives = 34/77 (44%), Gaps = 4/77 (5%)
Query: 835 TDGSNRKSIRKDLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACP 894
T GS + + +D + +R + N C +NGGCSH C T C CP
Sbjct: 378 TQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGP----LCTCP 433
Query: 895 AHYRLNKDNITCSEPEE 911
Y L+ D TC + ++
Sbjct: 434 RGYELDTDQRTCIDVDD 450
Score = 39.1 bits (87), Expect = 0.094
Identities = 14/36 (38%), Positives = 17/36 (47%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA GGC H C N + C C G L D++ C
Sbjct: 491 CASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGC 526
Score = 37.1 bits (82), Expect = 0.38
Identities = 16/38 (42%), Positives = 20/38 (52%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
+PCA+ NG C H C C C +G +L AD K C
Sbjct: 321 SPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKAC 358
Score = 37.1 bits (82), Expect = 0.38
Identities = 18/41 (43%), Positives = 21/41 (51%), Gaps = 3/41 (7%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYD 300
C+ NN GCSH C S G C CP G +L + TC D
Sbjct: 410 CEANNGGCSHGC--SHTSAGPLCTCPRGYEL-DTDQRTCID 447
Score = 35.5 bits (78), Expect = 1.2
Identities = 15/42 (35%), Positives = 21/42 (50%), Gaps = 3/42 (7%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
N C + NGGC H C+ T +RC C ++L +D C
Sbjct: 279 NSCALGNGGCQHHCVQL---TITRHRCQCRPGFQLQEDGRHC 317
Score = 35.5 bits (78), Expect = 1.2
Identities = 17/46 (36%), Positives = 21/46 (45%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYS 613
CA C+H C N + C C G EL AD + C E +V S
Sbjct: 364 CAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNS 409
Score = 35.5 bits (78), Expect = 1.2
Identities = 16/36 (44%), Positives = 19/36 (52%), Gaps = 1/36 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CAD + C +C N P Y CGC G L+AD C
Sbjct: 451 CAD-SPCCQQVCTNNPGGYECGCYAGYRLSADGCGC 485
Score = 35.1 bits (77), Expect = 1.5
Identities = 14/37 (37%), Positives = 20/37 (54%), Gaps = 2/37 (5%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSST 296
C+ +N GC H C+ +P Y C C G +L +S T
Sbjct: 240 CRTHNGGCQHRCVNTPG--SYLCECKPGFRLHTDSRT 274
Score = 33.9 bits (74), Expect = 3.5
Identities = 17/43 (39%), Positives = 20/43 (46%), Gaps = 1/43 (2%)
Query: 563 LGWNPCADDNGGCSHLCFNRP-DDYICGCPLGLELTADKKTCV 604
L N CA NGGC H C + C C G +L D + CV
Sbjct: 276 LAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCV 318
Score = 33.1 bits (72), Expect = 6.2
Identities = 15/42 (35%), Positives = 20/42 (47%), Gaps = 4/42 (9%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
D+ C +C PG Y C C A YRL+ D C + +E
Sbjct: 453 DSPCCQQVCTNNPGG----YECGCYAGYRLSADGCGCEDVDE 490
>AB011539-1|BAA32467.2| 1246|Homo sapiens MEGF6 protein.
Length = 1246
Score = 48.8 bits (111), Expect = 1e-04
Identities = 18/40 (45%), Positives = 25/40 (62%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
N C +NGGCSH C + +C CP G EL D++TC++
Sbjct: 245 NSCEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCID 284
Score = 48.4 bits (110), Expect = 2e-04
Identities = 17/37 (45%), Positives = 20/37 (54%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
C NGGC H C N P Y+C C G L D +TC+
Sbjct: 77 CRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCL 113
Score = 44.0 bits (99), Expect = 0.003
Identities = 18/42 (42%), Positives = 24/42 (57%), Gaps = 4/42 (9%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
++C NGGC H C+ TPG Y C C +RL+ D+ TC
Sbjct: 75 DECRTHNGGCQHRCVNTPG----SYLCECKPGFRLHTDSRTC 112
Score = 40.7 bits (91), Expect = 0.031
Identities = 18/47 (38%), Positives = 25/47 (53%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
++C GGC H C G ++C+C A YRL++D CS EE
Sbjct: 326 DECASSRGGCEHHCTNLAGS----FQCSCEAGYRLHEDRRGCSPLEE 368
Score = 39.9 bits (89), Expect = 0.054
Identities = 23/77 (29%), Positives = 34/77 (44%), Gaps = 4/77 (5%)
Query: 835 TDGSNRKSIRKDLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACP 894
T GS + + +D + +R + N C +NGGCSH C T C CP
Sbjct: 215 TQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGP----LCTCP 270
Query: 895 AHYRLNKDNITCSEPEE 911
Y L+ D TC + ++
Sbjct: 271 RGYELDTDQRTCIDVDD 287
Score = 39.1 bits (87), Expect = 0.094
Identities = 14/36 (38%), Positives = 17/36 (47%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA GGC H C N + C C G L D++ C
Sbjct: 328 CASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGC 363
Score = 37.1 bits (82), Expect = 0.38
Identities = 16/38 (42%), Positives = 20/38 (52%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
+PCA+ NG C H C C C +G +L AD K C
Sbjct: 158 SPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKAC 195
Score = 37.1 bits (82), Expect = 0.38
Identities = 18/41 (43%), Positives = 21/41 (51%), Gaps = 3/41 (7%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYD 300
C+ NN GCSH C S G C CP G +L + TC D
Sbjct: 247 CEANNGGCSHGC--SHTSAGPLCTCPRGYEL-DTDQRTCID 284
Score = 35.5 bits (78), Expect = 1.2
Identities = 15/42 (35%), Positives = 21/42 (50%), Gaps = 3/42 (7%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
N C + NGGC H C+ T +RC C ++L +D C
Sbjct: 116 NSCALGNGGCQHHCVQL---TITRHRCQCRPGFQLQEDGRHC 154
Score = 35.5 bits (78), Expect = 1.2
Identities = 17/46 (36%), Positives = 21/46 (45%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYS 613
CA C+H C N + C C G EL AD + C E +V S
Sbjct: 201 CAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNS 246
Score = 35.5 bits (78), Expect = 1.2
Identities = 16/36 (44%), Positives = 19/36 (52%), Gaps = 1/36 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CAD + C +C N P Y CGC G L+AD C
Sbjct: 288 CAD-SPCCQQVCTNNPGGYECGCYAGYRLSADGCGC 322
Score = 35.1 bits (77), Expect = 1.5
Identities = 14/37 (37%), Positives = 20/37 (54%), Gaps = 2/37 (5%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSST 296
C+ +N GC H C+ +P Y C C G +L +S T
Sbjct: 77 CRTHNGGCQHRCVNTPG--SYLCECKPGFRLHTDSRT 111
Score = 33.9 bits (74), Expect = 3.5
Identities = 17/43 (39%), Positives = 20/43 (46%), Gaps = 1/43 (2%)
Query: 563 LGWNPCADDNGGCSHLCFNRP-DDYICGCPLGLELTADKKTCV 604
L N CA NGGC H C + C C G +L D + CV
Sbjct: 113 LAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCV 155
Score = 33.1 bits (72), Expect = 6.2
Identities = 15/42 (35%), Positives = 20/42 (47%), Gaps = 4/42 (9%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
D+ C +C PG Y C C A YRL+ D C + +E
Sbjct: 290 DSPCCQQVCTNNPGG----YECGCYAGYRLSADGCGCEDVDE 327
>BC126440-1|AAI26441.1| 321|Homo sapiens OIT3 protein protein.
Length = 321
Score = 48.4 bits (110), Expect = 2e-04
Identities = 19/42 (45%), Positives = 25/42 (59%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPE 607
N C +NGGCS +C N + Y C C +G L +D KTC + E
Sbjct: 184 NECEQNNGGCSEICVNLKNSYRCECGVGRVLRSDGKTCEDVE 225
Score = 48.4 bits (110), Expect = 2e-04
Identities = 19/39 (48%), Positives = 22/39 (56%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEP 606
C ++NGGCSH C Y C CP GL L+ D TC P
Sbjct: 227 CHNNNGGCSHSCLGSEKGYQCECPRGLVLSEDNHTCQVP 265
Score = 43.6 bits (98), Expect = 0.004
Identities = 19/37 (51%), Positives = 22/37 (59%), Gaps = 2/37 (5%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSST 296
C NN GCSH CL S GY C CP G+ L E++ T
Sbjct: 227 CHNNNGGCSHSCLGS--EKGYQCECPRGLVLSEDNHT 261
Score = 41.9 bits (94), Expect = 0.013
Identities = 19/43 (44%), Positives = 24/43 (55%), Gaps = 4/43 (9%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEP 909
C +NGGCSH CL + Y+C CP L++DN TC P
Sbjct: 227 CHNNNGGCSHSCLGS----EKGYQCECPRGLVLSEDNHTCQVP 265
Score = 40.7 bits (91), Expect = 0.031
Identities = 18/53 (33%), Positives = 26/53 (49%), Gaps = 4/53 (7%)
Query: 858 RAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPE 910
R N+C +NGGCS +C+ +++ YRC C L D TC + E
Sbjct: 177 RQTCFDENECEQNNGGCSEICV----NLKNSYRCECGVGRVLRSDGKTCEDVE 225
Score = 35.1 bits (77), Expect = 1.5
Identities = 16/45 (35%), Positives = 24/45 (53%), Gaps = 3/45 (6%)
Query: 256 EDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYD 300
++ C++NN GCS +C+ + Y C C G LR + TC D
Sbjct: 182 DENECEQNNGGCSEICVNLKN--SYRCECGVGRVLRSDGK-TCED 223
>AY358339-1|AAQ88705.1| 545|Homo sapiens PPFL826 protein.
Length = 545
Score = 48.4 bits (110), Expect = 2e-04
Identities = 19/42 (45%), Positives = 25/42 (59%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPE 607
N C +NGGCS +C N + Y C C +G L +D KTC + E
Sbjct: 184 NECEQNNGGCSEICVNLKNSYRCECGVGRVLRSDGKTCEDVE 225
Score = 48.4 bits (110), Expect = 2e-04
Identities = 19/39 (48%), Positives = 22/39 (56%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEP 606
C ++NGGCSH C Y C CP GL L+ D TC P
Sbjct: 227 CHNNNGGCSHSCLGSEKGYQCECPRGLVLSEDNHTCQVP 265
Score = 43.6 bits (98), Expect = 0.004
Identities = 19/37 (51%), Positives = 22/37 (59%), Gaps = 2/37 (5%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSST 296
C NN GCSH CL S GY C CP G+ L E++ T
Sbjct: 227 CHNNNGGCSHSCLGS--EKGYQCECPRGLVLSEDNHT 261
Score = 41.9 bits (94), Expect = 0.013
Identities = 19/43 (44%), Positives = 24/43 (55%), Gaps = 4/43 (9%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEP 909
C +NGGCSH CL + Y+C CP L++DN TC P
Sbjct: 227 CHNNNGGCSHSCLGS----EKGYQCECPRGLVLSEDNHTCQVP 265
Score = 40.7 bits (91), Expect = 0.031
Identities = 18/53 (33%), Positives = 26/53 (49%), Gaps = 4/53 (7%)
Query: 858 RAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPE 910
R N+C +NGGCS +C+ +++ YRC C L D TC + E
Sbjct: 177 RQTCFDENECEQNNGGCSEICV----NLKNSYRCECGVGRVLRSDGKTCEDVE 225
Score = 35.1 bits (77), Expect = 1.5
Identities = 16/45 (35%), Positives = 24/45 (53%), Gaps = 3/45 (6%)
Query: 256 EDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYD 300
++ C++NN GCS +C+ + Y C C G LR + TC D
Sbjct: 182 DENECEQNNGGCSEICVNLKN--SYRCECGVGRVLRSDGK-TCED 223
>AY013707-1|AAG40096.2| 545|Homo sapiens LZP protein.
Length = 545
Score = 48.4 bits (110), Expect = 2e-04
Identities = 19/42 (45%), Positives = 25/42 (59%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPE 607
N C +NGGCS +C N + Y C C +G L +D KTC + E
Sbjct: 184 NECEQNNGGCSEICVNLKNSYRCECGVGRVLRSDGKTCEDVE 225
Score = 48.4 bits (110), Expect = 2e-04
Identities = 19/39 (48%), Positives = 22/39 (56%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEP 606
C ++NGGCSH C Y C CP GL L+ D TC P
Sbjct: 227 CHNNNGGCSHSCLGSEKGYQCECPRGLVLSEDNHTCQVP 265
Score = 43.6 bits (98), Expect = 0.004
Identities = 19/37 (51%), Positives = 22/37 (59%), Gaps = 2/37 (5%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSST 296
C NN GCSH CL S GY C CP G+ L E++ T
Sbjct: 227 CHNNNGGCSHSCLGS--EKGYQCECPRGLVLSEDNHT 261
Score = 41.9 bits (94), Expect = 0.013
Identities = 19/43 (44%), Positives = 24/43 (55%), Gaps = 4/43 (9%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEP 909
C +NGGCSH CL + Y+C CP L++DN TC P
Sbjct: 227 CHNNNGGCSHSCLGS----EKGYQCECPRGLVLSEDNHTCQVP 265
Score = 40.7 bits (91), Expect = 0.031
Identities = 18/53 (33%), Positives = 26/53 (49%), Gaps = 4/53 (7%)
Query: 858 RAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPE 910
R N+C +NGGCS +C+ +++ YRC C L D TC + E
Sbjct: 177 RQTCFDENECEQNNGGCSEICV----NLKNSYRCECGVGRVLRSDGKTCEDVE 225
Score = 35.1 bits (77), Expect = 1.5
Identities = 16/45 (35%), Positives = 24/45 (53%), Gaps = 3/45 (6%)
Query: 256 EDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYD 300
++ C++NN GCS +C+ + Y C C G LR + TC D
Sbjct: 182 DENECEQNNGGCSEICVNLKN--SYRCECGVGRVLRSDGK-TCED 223
>AK096435-1|BAC04788.1| 545|Homo sapiens protein ( Homo sapiens
cDNA FLJ39116 fis, clone NTONG2006301, highly similar to
Mus musculus EF-9 mRNA. ).
Length = 545
Score = 48.4 bits (110), Expect = 2e-04
Identities = 19/42 (45%), Positives = 25/42 (59%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPE 607
N C +NGGCS +C N + Y C C +G L +D KTC + E
Sbjct: 184 NECEQNNGGCSEICVNLKNSYRCECGVGRVLRSDGKTCEDVE 225
Score = 48.4 bits (110), Expect = 2e-04
Identities = 19/39 (48%), Positives = 22/39 (56%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEP 606
C ++NGGCSH C Y C CP GL L+ D TC P
Sbjct: 227 CHNNNGGCSHSCLGSEKGYQCECPRGLVLSEDNHTCQVP 265
Score = 43.6 bits (98), Expect = 0.004
Identities = 19/37 (51%), Positives = 22/37 (59%), Gaps = 2/37 (5%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSST 296
C NN GCSH CL S GY C CP G+ L E++ T
Sbjct: 227 CHNNNGGCSHSCLGS--EKGYQCECPRGLVLSEDNHT 261
Score = 41.9 bits (94), Expect = 0.013
Identities = 19/43 (44%), Positives = 24/43 (55%), Gaps = 4/43 (9%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEP 909
C +NGGCSH CL + Y+C CP L++DN TC P
Sbjct: 227 CHNNNGGCSHSCLGS----EKGYQCECPRGLVLSEDNHTCQVP 265
Score = 40.7 bits (91), Expect = 0.031
Identities = 18/53 (33%), Positives = 26/53 (49%), Gaps = 4/53 (7%)
Query: 858 RAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPE 910
R N+C +NGGCS +C+ +++ YRC C L D TC + E
Sbjct: 177 RQTCFDENECEQNNGGCSEICV----NLKNSYRCECGVGRVLRSDGKTCEDVE 225
Score = 35.1 bits (77), Expect = 1.5
Identities = 16/45 (35%), Positives = 24/45 (53%), Gaps = 3/45 (6%)
Query: 256 EDYPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYD 300
++ C++NN GCS +C+ + Y C C G LR + TC D
Sbjct: 182 DENECEQNNGGCSEICVNLKN--SYRCECGVGRVLRSDGK-TCED 223
>U69263-1|AAC51260.2| 956|Homo sapiens matrilin-2 precursor
protein.
Length = 956
Score = 48.0 bits (109), Expect = 2e-04
Identities = 18/38 (47%), Positives = 21/38 (55%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
CA +N GC H C N Y+C C G L DKKTC +
Sbjct: 324 CASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTK 361
Score = 48.0 bits (109), Expect = 2e-04
Identities = 19/36 (52%), Positives = 19/36 (52%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA N GC H C N D Y C C G L DKKTC
Sbjct: 365 CASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTC 400
Score = 42.3 bits (95), Expect = 0.010
Identities = 15/36 (41%), Positives = 19/36 (52%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA + GC LC N D ++C C G + D KTC
Sbjct: 447 CAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTC 482
Score = 40.7 bits (91), Expect = 0.031
Identities = 15/36 (41%), Positives = 18/36 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
C + GC H+C N D Y C C +G L D K C
Sbjct: 570 CQAIDHGCEHICVNSDDSYTCECLVGFRLAEDGKRC 605
Score = 39.9 bits (89), Expect = 0.054
Identities = 14/36 (38%), Positives = 19/36 (52%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
C+ C+H C N P Y+C C G L +D+ TC
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTC 277
Score = 39.5 bits (88), Expect = 0.071
Identities = 14/36 (38%), Positives = 18/36 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
C + GC H+C N + YIC C G L D + C
Sbjct: 611 CKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC 646
Score = 39.1 bits (87), Expect = 0.094
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
N CA + GC H C N + Y C C G L + KTC
Sbjct: 404 NYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTC 441
Score = 38.7 bits (86), Expect = 0.12
Identities = 15/37 (40%), Positives = 19/37 (51%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
CA ++ C LC N P ++C C G L D K CV
Sbjct: 283 CAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCV 319
Score = 37.5 bits (83), Expect = 0.29
Identities = 15/36 (41%), Positives = 19/36 (52%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA + GC H C + D ++C C G L D KTC
Sbjct: 529 CALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTC 564
Score = 35.9 bits (79), Expect = 0.87
Identities = 18/57 (31%), Positives = 23/57 (40%), Gaps = 4/57 (7%)
Query: 850 ISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
I L + K ++ C C+H C+ PG Y C C Y LN D TC
Sbjct: 225 IETLTSVFQKKLCTAHMCSTLEHNCAHFCINIPGS----YVCRCKQGYILNSDQTTC 277
Score = 35.9 bits (79), Expect = 0.87
Identities = 14/38 (36%), Positives = 19/38 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
C + GC + C N + C CP G L +D KTC +
Sbjct: 488 CLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAK 525
Score = 34.7 bits (76), Expect = 2.0
Identities = 15/42 (35%), Positives = 20/42 (47%), Gaps = 4/42 (9%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSE 908
C +N GC H C+ G Y C C + LN D TC++
Sbjct: 324 CASENHGCEHECVNADGS----YLCQCHEGFALNPDKKTCTK 361
Score = 32.7 bits (71), Expect = 8.1
Identities = 14/43 (32%), Positives = 21/43 (48%), Gaps = 4/43 (9%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS 907
N C ++ GC H C+ ++ Y C C Y L+ + TCS
Sbjct: 404 NYCALNKPGCEHECV----NMEESYYCRCHRGYTLDPNGKTCS 442
>BC016394-1|AAH16394.1| 715|Homo sapiens MATN2 protein protein.
Length = 715
Score = 48.0 bits (109), Expect = 2e-04
Identities = 19/36 (52%), Positives = 19/36 (52%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA N GC H C N D Y C C G L DKKTC
Sbjct: 124 CASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTC 159
Score = 46.4 bits (105), Expect = 6e-04
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
CA +N GC H C N Y+C C G L D+KTC +
Sbjct: 83 CASENHGCEHECVNADGSYLCQCHEGFALNPDEKTCTK 120
Score = 42.3 bits (95), Expect = 0.010
Identities = 15/36 (41%), Positives = 19/36 (52%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA + GC LC N D ++C C G + D KTC
Sbjct: 206 CAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTC 241
Score = 39.9 bits (89), Expect = 0.054
Identities = 14/36 (38%), Positives = 19/36 (52%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
C+ C+H C N P Y+C C G L +D+ TC
Sbjct: 1 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTC 36
Score = 39.5 bits (88), Expect = 0.071
Identities = 14/36 (38%), Positives = 18/36 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
C + GC H+C N + YIC C G L D + C
Sbjct: 370 CKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC 405
Score = 39.1 bits (87), Expect = 0.094
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
N CA + GC H C N + Y C C G L + KTC
Sbjct: 163 NYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTC 200
Score = 39.1 bits (87), Expect = 0.094
Identities = 15/36 (41%), Positives = 17/36 (47%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
C + GC H+C N D Y C C G L D K C
Sbjct: 329 CQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRC 364
Score = 38.7 bits (86), Expect = 0.12
Identities = 15/37 (40%), Positives = 19/37 (51%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
CA ++ C LC N P ++C C G L D K CV
Sbjct: 42 CAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCV 78
Score = 37.5 bits (83), Expect = 0.29
Identities = 15/36 (41%), Positives = 19/36 (52%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA + GC H C + D ++C C G L D KTC
Sbjct: 288 CALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTC 323
Score = 35.9 bits (79), Expect = 0.87
Identities = 14/38 (36%), Positives = 19/38 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
C + GC + C N + C CP G L +D KTC +
Sbjct: 247 CLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAK 284
Score = 34.7 bits (76), Expect = 2.0
Identities = 15/42 (35%), Positives = 20/42 (47%), Gaps = 4/42 (9%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSE 908
C +N GC H C+ G Y C C + LN D TC++
Sbjct: 83 CASENHGCEHECVNADGS----YLCQCHEGFALNPDEKTCTK 120
Score = 34.3 bits (75), Expect = 2.7
Identities = 15/40 (37%), Positives = 17/40 (42%), Gaps = 4/40 (10%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
C C+H C+ PG Y C C Y LN D TC
Sbjct: 1 CSTLEHNCAHFCINIPGS----YVCRCKQGYILNSDQTTC 36
Score = 32.7 bits (71), Expect = 8.1
Identities = 14/43 (32%), Positives = 21/43 (48%), Gaps = 4/43 (9%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS 907
N C ++ GC H C+ ++ Y C C Y L+ + TCS
Sbjct: 163 NYCALNKPGCEHECV----NMEESYYCRCHRGYTLDPNGKTCS 201
>BC010444-1|AAH10444.1| 937|Homo sapiens matrilin 2 protein.
Length = 937
Score = 48.0 bits (109), Expect = 2e-04
Identities = 19/36 (52%), Positives = 19/36 (52%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA N GC H C N D Y C C G L DKKTC
Sbjct: 365 CASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTC 400
Score = 46.4 bits (105), Expect = 6e-04
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
CA +N GC H C N Y+C C G L D+KTC +
Sbjct: 324 CASENHGCEHECVNADGSYLCQCHEGFALNPDEKTCTK 361
Score = 42.3 bits (95), Expect = 0.010
Identities = 15/36 (41%), Positives = 19/36 (52%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA + GC LC N D ++C C G + D KTC
Sbjct: 447 CAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTC 482
Score = 39.9 bits (89), Expect = 0.054
Identities = 14/36 (38%), Positives = 19/36 (52%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
C+ C+H C N P Y+C C G L +D+ TC
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTC 277
Score = 39.5 bits (88), Expect = 0.071
Identities = 14/36 (38%), Positives = 18/36 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
C + GC H+C N + YIC C G L D + C
Sbjct: 611 CKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC 646
Score = 39.1 bits (87), Expect = 0.094
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
N CA + GC H C N + Y C C G L + KTC
Sbjct: 404 NYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTC 441
Score = 39.1 bits (87), Expect = 0.094
Identities = 15/36 (41%), Positives = 17/36 (47%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
C + GC H+C N D Y C C G L D K C
Sbjct: 570 CQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRC 605
Score = 38.7 bits (86), Expect = 0.12
Identities = 15/37 (40%), Positives = 19/37 (51%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
CA ++ C LC N P ++C C G L D K CV
Sbjct: 283 CAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCV 319
Score = 37.5 bits (83), Expect = 0.29
Identities = 15/36 (41%), Positives = 19/36 (52%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA + GC H C + D ++C C G L D KTC
Sbjct: 529 CALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTC 564
Score = 35.9 bits (79), Expect = 0.87
Identities = 18/57 (31%), Positives = 23/57 (40%), Gaps = 4/57 (7%)
Query: 850 ISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
I L + K ++ C C+H C+ PG Y C C Y LN D TC
Sbjct: 225 IETLTSVFQKKLCTAHMCSTLEHNCAHFCINIPGS----YVCRCKQGYILNSDQTTC 277
Score = 35.9 bits (79), Expect = 0.87
Identities = 14/38 (36%), Positives = 19/38 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
C + GC + C N + C CP G L +D KTC +
Sbjct: 488 CLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAK 525
Score = 34.7 bits (76), Expect = 2.0
Identities = 15/42 (35%), Positives = 20/42 (47%), Gaps = 4/42 (9%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSE 908
C +N GC H C+ G Y C C + LN D TC++
Sbjct: 324 CASENHGCEHECVNADGS----YLCQCHEGFALNPDEKTCTK 361
Score = 32.7 bits (71), Expect = 8.1
Identities = 14/43 (32%), Positives = 21/43 (48%), Gaps = 4/43 (9%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS 907
N C ++ GC H C+ ++ Y C C Y L+ + TCS
Sbjct: 404 NYCALNKPGCEHECV----NMEESYYCRCHRGYTLDPNGKTCS 442
>AL833931-1|CAD38787.1| 1016|Homo sapiens hypothetical protein
protein.
Length = 1016
Score = 48.0 bits (109), Expect = 2e-04
Identities = 19/36 (52%), Positives = 19/36 (52%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA N GC H C N D Y C C G L DKKTC
Sbjct: 425 CASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTC 460
Score = 46.4 bits (105), Expect = 6e-04
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
CA +N GC H C N Y+C C G L D+KTC +
Sbjct: 384 CASENHGCEHECVNADGSYLCQCHEGFALNPDEKTCTK 421
Score = 42.3 bits (95), Expect = 0.010
Identities = 15/36 (41%), Positives = 19/36 (52%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA + GC LC N D ++C C G + D KTC
Sbjct: 507 CAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTC 542
Score = 39.9 bits (89), Expect = 0.054
Identities = 14/36 (38%), Positives = 19/36 (52%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
C+ C+H C N P Y+C C G L +D+ TC
Sbjct: 302 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTC 337
Score = 39.5 bits (88), Expect = 0.071
Identities = 14/36 (38%), Positives = 18/36 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
C + GC H+C N + YIC C G L D + C
Sbjct: 671 CKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC 706
Score = 39.1 bits (87), Expect = 0.094
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
N CA + GC H C N + Y C C G L + KTC
Sbjct: 464 NYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTC 501
Score = 39.1 bits (87), Expect = 0.094
Identities = 15/36 (41%), Positives = 17/36 (47%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
C + GC H+C N D Y C C G L D K C
Sbjct: 630 CQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRC 665
Score = 38.7 bits (86), Expect = 0.12
Identities = 15/37 (40%), Positives = 19/37 (51%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
CA ++ C LC N P ++C C G L D K CV
Sbjct: 343 CAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCV 379
Score = 37.5 bits (83), Expect = 0.29
Identities = 15/36 (41%), Positives = 19/36 (52%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA + GC H C + D ++C C G L D KTC
Sbjct: 589 CALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTC 624
Score = 35.9 bits (79), Expect = 0.87
Identities = 18/57 (31%), Positives = 23/57 (40%), Gaps = 4/57 (7%)
Query: 850 ISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
I L + K ++ C C+H C+ PG Y C C Y LN D TC
Sbjct: 285 IETLTSVFQKKLCTAHMCSTLEHNCAHFCINIPGS----YVCRCKQGYILNSDQTTC 337
Score = 35.9 bits (79), Expect = 0.87
Identities = 14/38 (36%), Positives = 19/38 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
C + GC + C N + C CP G L +D KTC +
Sbjct: 548 CLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAK 585
Score = 34.7 bits (76), Expect = 2.0
Identities = 15/42 (35%), Positives = 20/42 (47%), Gaps = 4/42 (9%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSE 908
C +N GC H C+ G Y C C + LN D TC++
Sbjct: 384 CASENHGCEHECVNADGS----YLCQCHEGFALNPDEKTCTK 421
Score = 32.7 bits (71), Expect = 8.1
Identities = 14/43 (32%), Positives = 21/43 (48%), Gaps = 4/43 (9%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS 907
N C ++ GC H C+ ++ Y C C Y L+ + TCS
Sbjct: 464 NYCALNKPGCEHECV----NMEESYYCRCHRGYTLDPNGKTCS 502
>AK075489-1|BAC11648.1| 451|Homo sapiens rase 7. protein.
Length = 451
Score = 48.0 bits (109), Expect = 2e-04
Identities = 18/38 (47%), Positives = 21/38 (55%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
CA +N GC H C N Y+C C G L DKKTC +
Sbjct: 324 CASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTK 361
Score = 48.0 bits (109), Expect = 2e-04
Identities = 19/36 (52%), Positives = 19/36 (52%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA N GC H C N D Y C C G L DKKTC
Sbjct: 365 CASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTC 400
Score = 39.9 bits (89), Expect = 0.054
Identities = 14/36 (38%), Positives = 19/36 (52%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
C+ C+H C N P Y+C C G L +D+ TC
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTC 277
Score = 39.1 bits (87), Expect = 0.094
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
N CA + GC H C N + Y C C G L + KTC
Sbjct: 404 NYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTC 441
Score = 38.7 bits (86), Expect = 0.12
Identities = 15/37 (40%), Positives = 19/37 (51%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
CA ++ C LC N P ++C C G L D K CV
Sbjct: 283 CAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCV 319
Score = 35.9 bits (79), Expect = 0.87
Identities = 18/57 (31%), Positives = 23/57 (40%), Gaps = 4/57 (7%)
Query: 850 ISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
I L + K ++ C C+H C+ PG Y C C Y LN D TC
Sbjct: 225 IETLTSVFQKKLCTAHMCSTLEHNCAHFCINIPGS----YVCRCKQGYILNSDQTTC 277
Score = 34.7 bits (76), Expect = 2.0
Identities = 15/42 (35%), Positives = 20/42 (47%), Gaps = 4/42 (9%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSE 908
C +N GC H C+ G Y C C + LN D TC++
Sbjct: 324 CASENHGCEHECVNADGS----YLCQCHEGFALNPDKKTCTK 361
Score = 32.7 bits (71), Expect = 8.1
Identities = 14/43 (32%), Positives = 21/43 (48%), Gaps = 4/43 (9%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS 907
N C ++ GC H C+ ++ Y C C Y L+ + TCS
Sbjct: 404 NYCALNKPGCEHECV----NMEESYYCRCHRGYTLDPNGKTCS 442
>Z99756-1|CAI18854.1| 988|Homo sapiens protein ( Human DNA sequence
from clone RP1-100N22 on chromosome 22q13.31-13.33. ).
Length = 988
Score = 46.8 bits (106), Expect = 5e-04
Identities = 17/38 (44%), Positives = 22/38 (57%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
N C +NGGC H C N + CGC G +L D++TC
Sbjct: 284 NECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTC 321
Score = 43.6 bits (98), Expect = 0.004
Identities = 19/47 (40%), Positives = 25/47 (53%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
N+C V+NGGC H C T G + C C Y+L D TC + +E
Sbjct: 284 NECLVNNGGCDHFCRNTVG----SFECGCRKGYKLLTDERTCQDIDE 326
Score = 42.7 bits (96), Expect = 0.008
Identities = 19/48 (39%), Positives = 24/48 (50%), Gaps = 4/48 (8%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL 914
C V+NGGC C D T RC+CP + L D TC + E L+
Sbjct: 245 CAVNNGGCDRTCK----DTATGVRCSCPVGFTLQPDGKTCKDINECLV 288
Score = 41.9 bits (94), Expect = 0.013
Identities = 15/37 (40%), Positives = 21/37 (56%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
C D+NGGC +C N Y C C G L+ ++ TC+
Sbjct: 121 CQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCI 157
Score = 41.9 bits (94), Expect = 0.013
Identities = 18/44 (40%), Positives = 22/44 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLV 611
CA +NGGC C + C CP+G L D KTC + LV
Sbjct: 245 CAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLV 288
Score = 37.9 bits (84), Expect = 0.22
Identities = 17/40 (42%), Positives = 21/40 (52%), Gaps = 2/40 (5%)
Query: 568 CADD--NGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
C +D NGGC H C N P +Y C C G L D C++
Sbjct: 78 CENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLD 117
Score = 37.1 bits (82), Expect = 0.38
Identities = 15/38 (39%), Positives = 19/38 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
C NGGC H C + CGC L +D +TC+E
Sbjct: 206 CNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIE 243
Score = 37.1 bits (82), Expect = 0.38
Identities = 16/38 (42%), Positives = 18/38 (47%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
C+ NG C C N Y C CP G L + K CVE
Sbjct: 366 CSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVE 403
Score = 35.9 bits (79), Expect = 0.87
Identities = 17/42 (40%), Positives = 18/42 (42%), Gaps = 4/42 (9%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSE 908
C NGGC H C D T C C Y L+ D TC E
Sbjct: 206 CNYGNGGCQHSC----EDTDTGPTCGCHQKYALHSDGRTCIE 243
Score = 35.1 bits (77), Expect = 1.5
Identities = 16/41 (39%), Positives = 21/41 (51%), Gaps = 4/41 (9%)
Query: 871 NGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
NGGC H C+ PG +YRC C + L D C + +E
Sbjct: 84 NGGCVHECINIPG----NYRCTCFDGFMLAHDGHNCLDVDE 120
Score = 33.9 bits (74), Expect = 3.5
Identities = 15/44 (34%), Positives = 21/44 (47%), Gaps = 4/44 (9%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSE 908
++C + NG C C+ T G Y C CP RL+ + C E
Sbjct: 364 DECSMSNGSCDQGCVNTKG----SYECVCPPGRRLHWNGKDCVE 403
Score = 33.5 bits (73), Expect = 4.7
Identities = 16/47 (34%), Positives = 21/47 (44%), Gaps = 3/47 (6%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLL 306
C NN GC C G C+CP G L+ + TC D + L+
Sbjct: 245 CAVNNGGCDRTC--KDTATGVRCSCPVGFTLQPDGK-TCKDINECLV 288
Score = 33.1 bits (72), Expect = 6.2
Identities = 14/42 (33%), Positives = 21/42 (50%), Gaps = 2/42 (4%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDS 301
C+ NN GC +C+ + Y C C +G L +N T + S
Sbjct: 121 CQDNNGGCQQICVNAMG--SYECQCHSGFFLSDNQHTCIHRS 160
>Z82214-3|CAI21674.1| 988|Homo sapiens protein ( Human DNA sequence
from clone RP3-526I14 on chromosome 22. ).
Length = 988
Score = 46.8 bits (106), Expect = 5e-04
Identities = 17/38 (44%), Positives = 22/38 (57%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
N C +NGGC H C N + CGC G +L D++TC
Sbjct: 284 NECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTC 321
Score = 43.6 bits (98), Expect = 0.004
Identities = 19/47 (40%), Positives = 25/47 (53%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
N+C V+NGGC H C T G + C C Y+L D TC + +E
Sbjct: 284 NECLVNNGGCDHFCRNTVG----SFECGCRKGYKLLTDERTCQDIDE 326
Score = 42.7 bits (96), Expect = 0.008
Identities = 19/48 (39%), Positives = 24/48 (50%), Gaps = 4/48 (8%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL 914
C V+NGGC C D T RC+CP + L D TC + E L+
Sbjct: 245 CAVNNGGCDRTCK----DTATGVRCSCPVGFTLQPDGKTCKDINECLV 288
Score = 41.9 bits (94), Expect = 0.013
Identities = 15/37 (40%), Positives = 21/37 (56%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
C D+NGGC +C N Y C C G L+ ++ TC+
Sbjct: 121 CQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCI 157
Score = 41.9 bits (94), Expect = 0.013
Identities = 18/44 (40%), Positives = 22/44 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLV 611
CA +NGGC C + C CP+G L D KTC + LV
Sbjct: 245 CAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLV 288
Score = 37.9 bits (84), Expect = 0.22
Identities = 17/40 (42%), Positives = 21/40 (52%), Gaps = 2/40 (5%)
Query: 568 CADD--NGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
C +D NGGC H C N P +Y C C G L D C++
Sbjct: 78 CENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLD 117
Score = 37.1 bits (82), Expect = 0.38
Identities = 15/38 (39%), Positives = 19/38 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
C NGGC H C + CGC L +D +TC+E
Sbjct: 206 CNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIE 243
Score = 37.1 bits (82), Expect = 0.38
Identities = 16/38 (42%), Positives = 18/38 (47%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
C+ NG C C N Y C CP G L + K CVE
Sbjct: 366 CSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVE 403
Score = 35.9 bits (79), Expect = 0.87
Identities = 17/42 (40%), Positives = 18/42 (42%), Gaps = 4/42 (9%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSE 908
C NGGC H C D T C C Y L+ D TC E
Sbjct: 206 CNYGNGGCQHSC----EDTDTGPTCGCHQKYALHSDGRTCIE 243
Score = 35.1 bits (77), Expect = 1.5
Identities = 16/41 (39%), Positives = 21/41 (51%), Gaps = 4/41 (9%)
Query: 871 NGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
NGGC H C+ PG +YRC C + L D C + +E
Sbjct: 84 NGGCVHECINIPG----NYRCTCFDGFMLAHDGHNCLDVDE 120
Score = 33.9 bits (74), Expect = 3.5
Identities = 15/44 (34%), Positives = 21/44 (47%), Gaps = 4/44 (9%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSE 908
++C + NG C C+ T G Y C CP RL+ + C E
Sbjct: 364 DECSMSNGSCDQGCVNTKG----SYECVCPPGRRLHWNGKDCVE 403
Score = 33.5 bits (73), Expect = 4.7
Identities = 16/47 (34%), Positives = 21/47 (44%), Gaps = 3/47 (6%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLL 306
C NN GC C G C+CP G L+ + TC D + L+
Sbjct: 245 CAVNNGGCDRTC--KDTATGVRCSCPVGFTLQPDGK-TCKDINECLV 288
Score = 33.1 bits (72), Expect = 6.2
Identities = 14/42 (33%), Positives = 21/42 (50%), Gaps = 2/42 (4%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDS 301
C+ NN GC +C+ + Y C C +G L +N T + S
Sbjct: 121 CQDNNGGCQQICVNAMG--SYECQCHSGFFLSDNQHTCIHRS 160
>BC127263-1|AAI27264.1| 363|Homo sapiens SCUBE1 protein protein.
Length = 363
Score = 46.8 bits (106), Expect = 5e-04
Identities = 17/38 (44%), Positives = 22/38 (57%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
N C +NGGC H C N + CGC G +L D++TC
Sbjct: 284 NECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTC 321
Score = 43.6 bits (98), Expect = 0.004
Identities = 19/47 (40%), Positives = 25/47 (53%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
N+C V+NGGC H C T G + C C Y+L D TC + +E
Sbjct: 284 NECLVNNGGCDHFCRNTVG----SFECGCRKGYKLLTDERTCQDIDE 326
Score = 42.7 bits (96), Expect = 0.008
Identities = 19/48 (39%), Positives = 24/48 (50%), Gaps = 4/48 (8%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL 914
C V+NGGC C D T RC+CP + L D TC + E L+
Sbjct: 245 CAVNNGGCDRTCK----DTATGVRCSCPVGFTLQPDGKTCKDINECLV 288
Score = 41.9 bits (94), Expect = 0.013
Identities = 15/37 (40%), Positives = 21/37 (56%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
C D+NGGC +C N Y C C G L+ ++ TC+
Sbjct: 121 CQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCI 157
Score = 41.9 bits (94), Expect = 0.013
Identities = 18/44 (40%), Positives = 22/44 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLV 611
CA +NGGC C + C CP+G L D KTC + LV
Sbjct: 245 CAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLV 288
Score = 37.9 bits (84), Expect = 0.22
Identities = 17/40 (42%), Positives = 21/40 (52%), Gaps = 2/40 (5%)
Query: 568 CADD--NGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
C +D NGGC H C N P +Y C C G L D C++
Sbjct: 78 CENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLD 117
Score = 37.9 bits (84), Expect = 0.22
Identities = 15/38 (39%), Positives = 20/38 (52%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
C NGGC H C + +CGC L +D +TC+E
Sbjct: 206 CNYGNGGCQHSCEDTDTGPMCGCHQKYALHSDGRTCIE 243
Score = 35.9 bits (79), Expect = 0.87
Identities = 17/42 (40%), Positives = 18/42 (42%), Gaps = 4/42 (9%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSE 908
C NGGC H C D T C C Y L+ D TC E
Sbjct: 206 CNYGNGGCQHSC----EDTDTGPMCGCHQKYALHSDGRTCIE 243
Score = 35.1 bits (77), Expect = 1.5
Identities = 16/41 (39%), Positives = 21/41 (51%), Gaps = 4/41 (9%)
Query: 871 NGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
NGGC H C+ PG +YRC C + L D C + +E
Sbjct: 84 NGGCVHECINIPG----NYRCTCFDGFMLAHDGHNCLDVDE 120
Score = 33.5 bits (73), Expect = 4.7
Identities = 16/47 (34%), Positives = 21/47 (44%), Gaps = 3/47 (6%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLL 306
C NN GC C G C+CP G L+ + TC D + L+
Sbjct: 245 CAVNNGGCDRTC--KDTATGVRCSCPVGFTLQPDGK-TCKDINECLV 288
Score = 33.1 bits (72), Expect = 6.2
Identities = 14/42 (33%), Positives = 21/42 (50%), Gaps = 2/42 (4%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDS 301
C+ NN GC +C+ + Y C C +G L +N T + S
Sbjct: 121 CQDNNGGCQQICVNAMG--SYECQCHSGFFLSDNQHTCIHRS 160
>AF525689-1|AAN77133.1| 988|Homo sapiens signal
peptide-CUB-EGF-like domain containing protein 1
protein.
Length = 988
Score = 46.8 bits (106), Expect = 5e-04
Identities = 17/38 (44%), Positives = 22/38 (57%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
N C +NGGC H C N + CGC G +L D++TC
Sbjct: 284 NECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTC 321
Score = 43.6 bits (98), Expect = 0.004
Identities = 19/47 (40%), Positives = 25/47 (53%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
N+C V+NGGC H C T G + C C Y+L D TC + +E
Sbjct: 284 NECLVNNGGCDHFCRNTVG----SFECGCRKGYKLLTDERTCQDIDE 326
Score = 42.7 bits (96), Expect = 0.008
Identities = 19/48 (39%), Positives = 24/48 (50%), Gaps = 4/48 (8%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL 914
C V+NGGC C D T RC+CP + L D TC + E L+
Sbjct: 245 CAVNNGGCDRTCK----DTATGVRCSCPVGFTLQPDGKTCKDINECLV 288
Score = 41.9 bits (94), Expect = 0.013
Identities = 15/37 (40%), Positives = 21/37 (56%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
C D+NGGC +C N Y C C G L+ ++ TC+
Sbjct: 121 CQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCI 157
Score = 41.9 bits (94), Expect = 0.013
Identities = 18/44 (40%), Positives = 22/44 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLV 611
CA +NGGC C + C CP+G L D KTC + LV
Sbjct: 245 CAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLV 288
Score = 38.7 bits (86), Expect = 0.12
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
C+ NG C C N Y C CP G L ++K CVE
Sbjct: 366 CSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNRKDCVE 403
Score = 37.9 bits (84), Expect = 0.22
Identities = 17/40 (42%), Positives = 21/40 (52%), Gaps = 2/40 (5%)
Query: 568 CADD--NGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
C +D NGGC H C N P +Y C C G L D C++
Sbjct: 78 CENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLD 117
Score = 35.1 bits (77), Expect = 1.5
Identities = 16/41 (39%), Positives = 21/41 (51%), Gaps = 4/41 (9%)
Query: 871 NGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
NGGC H C+ PG +YRC C + L D C + +E
Sbjct: 84 NGGCVHECINIPG----NYRCTCFDGFMLAHDGHNCLDVDE 120
Score = 34.3 bits (75), Expect = 2.7
Identities = 14/38 (36%), Positives = 18/38 (47%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
C NGGC H C + CGC +D +TC+E
Sbjct: 206 CNYGNGGCQHSCEDTDTGPTCGCHQKYAPHSDGRTCIE 243
Score = 33.9 bits (74), Expect = 3.5
Identities = 15/44 (34%), Positives = 21/44 (47%), Gaps = 4/44 (9%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSE 908
++C + NG C C+ T G Y C CP RL+ + C E
Sbjct: 364 DECSMSNGSCDQGCVNTKG----SYECVCPPGRRLHWNRKDCVE 403
Score = 33.5 bits (73), Expect = 4.7
Identities = 16/47 (34%), Positives = 21/47 (44%), Gaps = 3/47 (6%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLL 306
C NN GC C G C+CP G L+ + TC D + L+
Sbjct: 245 CAVNNGGCDRTC--KDTATGVRCSCPVGFTLQPDGK-TCKDINECLV 288
Score = 33.1 bits (72), Expect = 6.2
Identities = 14/42 (33%), Positives = 21/42 (50%), Gaps = 2/42 (4%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDS 301
C+ NN GC +C+ + Y C C +G L +N T + S
Sbjct: 121 CQDNNGGCQQICVNAMG--SYECQCHSGFFLSDNQHTCIHRS 160
Score = 33.1 bits (72), Expect = 6.2
Identities = 16/42 (38%), Positives = 17/42 (40%), Gaps = 4/42 (9%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSE 908
C NGGC H C D T C C Y + D TC E
Sbjct: 206 CNYGNGGCQHSC----EDTDTGPTCGCHQKYAPHSDGRTCIE 243
>BC007408-1|AAH07408.1| 770|Homo sapiens low density lipoprotein
receptor-related protein 3 protein.
Length = 770
Score = 46.4 bits (105), Expect = 6e-04
Identities = 30/91 (32%), Positives = 34/91 (37%), Gaps = 11/91 (12%)
Query: 1095 RQCDGQQDCEDGRDEAECGAC--------GGDVRC---ADGTXXXXXXXXXXXXXXXXXX 1143
++CDG C GRDE C AC GG C AD
Sbjct: 396 QRCDGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFSC 455
Query: 1144 XXDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
F C LCI + CDG+ C DGSDE
Sbjct: 456 QPGTFHCGTNLCIFETWRCDGQEDCQDGSDE 486
Score = 37.9 bits (84), Expect = 0.22
Identities = 14/29 (48%), Positives = 18/29 (62%)
Query: 1146 DAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
D FRCD G C+ + C+ +C DGSDE
Sbjct: 169 DEFRCDNGKCLPGPWQCNTVDECGDGSDE 197
Score = 37.9 bits (84), Expect = 0.22
Identities = 17/26 (65%), Positives = 18/26 (69%), Gaps = 2/26 (7%)
Query: 1093 VSRQCDGQQDCEDGRDEAECG--ACG 1116
V R+CDG QDC DG DEA C ACG
Sbjct: 230 VERRCDGLQDCGDGSDEAGCPDLACG 255
Score = 33.5 bits (73), Expect = 4.7
Identities = 11/17 (64%), Positives = 14/17 (82%)
Query: 1096 QCDGQQDCEDGRDEAEC 1112
+CDGQ+DC+DG DE C
Sbjct: 473 RCDGQEDCQDGSDEHGC 489
>AB009462-1|BAA32330.1| 770|Homo sapiens LDL receptor related protein
105 protein.
Length = 770
Score = 46.4 bits (105), Expect = 6e-04
Identities = 30/91 (32%), Positives = 34/91 (37%), Gaps = 11/91 (12%)
Query: 1095 RQCDGQQDCEDGRDEAECGAC--------GGDVRC---ADGTXXXXXXXXXXXXXXXXXX 1143
++CDG C GRDE C AC GG C AD
Sbjct: 396 QRCDGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFSC 455
Query: 1144 XXDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
F C LCI + CDG+ C DGSDE
Sbjct: 456 QPGTFHCGTNLCIFETWRCDGQEDCQDGSDE 486
Score = 37.9 bits (84), Expect = 0.22
Identities = 14/29 (48%), Positives = 18/29 (62%)
Query: 1146 DAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
D FRCD G C+ + C+ +C DGSDE
Sbjct: 169 DEFRCDNGKCLPGPWQCNTVDECGDGSDE 197
Score = 37.9 bits (84), Expect = 0.22
Identities = 17/26 (65%), Positives = 18/26 (69%), Gaps = 2/26 (7%)
Query: 1093 VSRQCDGQQDCEDGRDEAECG--ACG 1116
V R+CDG QDC DG DEA C ACG
Sbjct: 230 VERRCDGLQDCGDGSDEAGCPDLACG 255
Score = 33.5 bits (73), Expect = 4.7
Identities = 11/17 (64%), Positives = 14/17 (82%)
Query: 1096 QCDGQQDCEDGRDEAEC 1112
+CDGQ+DC+DG DE C
Sbjct: 473 RCDGQEDCQDGSDEHGC 489
>AY358895-1|AAQ89254.1| 915|Homo sapiens MATN2 protein.
Length = 915
Score = 46.0 bits (104), Expect = 8e-04
Identities = 17/36 (47%), Positives = 20/36 (55%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA +N GC H C N Y+C C G L D+KTC
Sbjct: 324 CASENHGCEHECVNADGSYLCQCHEGFALNPDEKTC 359
Score = 42.3 bits (95), Expect = 0.010
Identities = 15/36 (41%), Positives = 19/36 (52%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA + GC LC N D ++C C G + D KTC
Sbjct: 406 CAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTC 441
Score = 39.9 bits (89), Expect = 0.054
Identities = 14/36 (38%), Positives = 19/36 (52%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
C+ C+H C N P Y+C C G L +D+ TC
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTC 277
Score = 39.5 bits (88), Expect = 0.071
Identities = 14/36 (38%), Positives = 18/36 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
C + GC H+C N + YIC C G L D + C
Sbjct: 570 CKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC 605
Score = 39.1 bits (87), Expect = 0.094
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
N CA + GC H C N + Y C C G L + KTC
Sbjct: 363 NYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTC 400
Score = 39.1 bits (87), Expect = 0.094
Identities = 15/36 (41%), Positives = 17/36 (47%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
C + GC H+C N D Y C C G L D K C
Sbjct: 529 CQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRC 564
Score = 38.7 bits (86), Expect = 0.12
Identities = 15/37 (40%), Positives = 19/37 (51%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
CA ++ C LC N P ++C C G L D K CV
Sbjct: 283 CAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCV 319
Score = 37.5 bits (83), Expect = 0.29
Identities = 15/36 (41%), Positives = 19/36 (52%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA + GC H C + D ++C C G L D KTC
Sbjct: 488 CALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTC 523
Score = 35.9 bits (79), Expect = 0.87
Identities = 18/57 (31%), Positives = 23/57 (40%), Gaps = 4/57 (7%)
Query: 850 ISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
I L + K ++ C C+H C+ PG Y C C Y LN D TC
Sbjct: 225 IETLTSVFQKKLCTAHMCSTLEHNCAHFCINIPGS----YVCRCKQGYILNSDQTTC 277
Score = 35.9 bits (79), Expect = 0.87
Identities = 14/38 (36%), Positives = 19/38 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
C + GC + C N + C CP G L +D KTC +
Sbjct: 447 CLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAK 484
Score = 34.3 bits (75), Expect = 2.7
Identities = 15/41 (36%), Positives = 19/41 (46%), Gaps = 4/41 (9%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS 907
C +N GC H C+ G Y C C + LN D TC+
Sbjct: 324 CASENHGCEHECVNADG----SYLCQCHEGFALNPDEKTCT 360
Score = 32.7 bits (71), Expect = 8.1
Identities = 14/43 (32%), Positives = 21/43 (48%), Gaps = 4/43 (9%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS 907
N C ++ GC H C+ ++ Y C C Y L+ + TCS
Sbjct: 363 NYCALNKPGCEHECV----NMEESYYCRCHRGYTLDPNGKTCS 401
>AK126750-1|BAC86671.1| 644|Homo sapiens protein ( Homo sapiens cDNA
FLJ44797 fis, clone BRACE3040644, highly similar to Homo
sapiens low density lipoprotein receptor-related protein
3 (LRP3). ).
Length = 644
Score = 46.0 bits (104), Expect = 8e-04
Identities = 30/91 (32%), Positives = 34/91 (37%), Gaps = 11/91 (12%)
Query: 1095 RQCDGQQDCEDGRDEAECGAC--------GGDVRC---ADGTXXXXXXXXXXXXXXXXXX 1143
++CDG C GRDE C AC GG C AD
Sbjct: 270 QRCDGWWHCASGRDEQGCPACPPDQYPCEGGGGLCYTPADRCNNQKSCPDGADEKNCFSC 329
Query: 1144 XXDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
F C LCI + CDG+ C DGSDE
Sbjct: 330 QPGTFHCGTNLCIFETWRCDGQEDCQDGSDE 360
Score = 37.9 bits (84), Expect = 0.22
Identities = 14/29 (48%), Positives = 18/29 (62%)
Query: 1146 DAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
D FRCD G C+ + C+ +C DGSDE
Sbjct: 43 DEFRCDNGKCLPGPWQCNTVDECGDGSDE 71
Score = 37.9 bits (84), Expect = 0.22
Identities = 17/26 (65%), Positives = 18/26 (69%), Gaps = 2/26 (7%)
Query: 1093 VSRQCDGQQDCEDGRDEAECG--ACG 1116
V R+CDG QDC DG DEA C ACG
Sbjct: 104 VERRCDGLQDCGDGSDEAGCPDLACG 129
Score = 33.5 bits (73), Expect = 4.7
Identities = 11/17 (64%), Positives = 14/17 (82%)
Query: 1096 QCDGQQDCEDGRDEAEC 1112
+CDGQ+DC+DG DE C
Sbjct: 347 RCDGQEDCQDGSDEHGC 363
>BC113577-1|AAI13578.1| 1015|Homo sapiens tolloid-like 2 protein.
Length = 1015
Score = 45.6 bits (103), Expect = 0.001
Identities = 18/33 (54%), Positives = 19/33 (57%)
Query: 571 DNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
D+GGC H C N Y C C G EL ADKK C
Sbjct: 584 DHGGCEHRCVNTLGSYKCACDPGYELAADKKMC 616
Score = 41.5 bits (93), Expect = 0.018
Identities = 24/76 (31%), Positives = 33/76 (43%), Gaps = 2/76 (2%)
Query: 550 NMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAF 609
N + + FR + CA DNGGC H C N Y+C C G L + C EA
Sbjct: 718 NTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENGHDC--KEAG 775
Query: 610 LVYSRKNIIGRLSIKN 625
+ ++ G L+ N
Sbjct: 776 CAHKISSVEGTLASPN 791
Score = 37.5 bits (83), Expect = 0.29
Identities = 17/44 (38%), Positives = 23/44 (52%), Gaps = 4/44 (9%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSE 908
++C DNGGC H C+ T G Y C C Y L+++ C E
Sbjct: 734 DECAKDNGGCQHECVNTFG----SYLCRCRNGYWLHENGHDCKE 773
Score = 35.9 bits (79), Expect = 0.87
Identities = 16/37 (43%), Positives = 19/37 (51%), Gaps = 4/37 (10%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
D+GGC H C+ T G Y+CAC Y L D C
Sbjct: 584 DHGGCEHRCVNTLG----SYKCACDPGYELAADKKMC 616
>BC112366-1|AAI12367.1| 1015|Homo sapiens tolloid-like 2 protein.
Length = 1015
Score = 45.6 bits (103), Expect = 0.001
Identities = 18/33 (54%), Positives = 19/33 (57%)
Query: 571 DNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
D+GGC H C N Y C C G EL ADKK C
Sbjct: 584 DHGGCEHRCVNTLGSYKCACDPGYELAADKKMC 616
Score = 41.5 bits (93), Expect = 0.018
Identities = 24/76 (31%), Positives = 33/76 (43%), Gaps = 2/76 (2%)
Query: 550 NMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAF 609
N + + FR + CA DNGGC H C N Y+C C G L + C EA
Sbjct: 718 NTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENGHDC--KEAG 775
Query: 610 LVYSRKNIIGRLSIKN 625
+ ++ G L+ N
Sbjct: 776 CAHKISSVEGTLASPN 791
Score = 37.5 bits (83), Expect = 0.29
Identities = 17/44 (38%), Positives = 23/44 (52%), Gaps = 4/44 (9%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSE 908
++C DNGGC H C+ T G Y C C Y L+++ C E
Sbjct: 734 DECAKDNGGCQHECVNTFG----SYLCRCRNGYWLHENGHDCKE 773
Score = 35.9 bits (79), Expect = 0.87
Identities = 16/37 (43%), Positives = 19/37 (51%), Gaps = 4/37 (10%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
D+GGC H C+ T G Y+CAC Y L D C
Sbjct: 584 DHGGCEHRCVNTLG----SYKCACDPGYELAADKKMC 616
>BC112341-1|AAI12342.1| 1015|Homo sapiens tolloid-like 2 protein.
Length = 1015
Score = 45.6 bits (103), Expect = 0.001
Identities = 18/33 (54%), Positives = 19/33 (57%)
Query: 571 DNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
D+GGC H C N Y C C G EL ADKK C
Sbjct: 584 DHGGCEHRCVNTLGSYKCACDPGYELAADKKMC 616
Score = 41.5 bits (93), Expect = 0.018
Identities = 24/76 (31%), Positives = 33/76 (43%), Gaps = 2/76 (2%)
Query: 550 NMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAF 609
N + + FR + CA DNGGC H C N Y+C C G L + C EA
Sbjct: 718 NTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENGHDC--KEAG 775
Query: 610 LVYSRKNIIGRLSIKN 625
+ ++ G L+ N
Sbjct: 776 CAHKISSVEGTLASPN 791
Score = 37.5 bits (83), Expect = 0.29
Identities = 17/44 (38%), Positives = 23/44 (52%), Gaps = 4/44 (9%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSE 908
++C DNGGC H C+ T G Y C C Y L+++ C E
Sbjct: 734 DECAKDNGGCQHECVNTFG----SYLCRCRNGYWLHENGHDCKE 773
Score = 35.9 bits (79), Expect = 0.87
Identities = 16/37 (43%), Positives = 19/37 (51%), Gaps = 4/37 (10%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
D+GGC H C+ T G Y+CAC Y L D C
Sbjct: 584 DHGGCEHRCVNTLG----SYKCACDPGYELAADKKMC 616
>AL391136-1|CAH72234.1| 1015|Homo sapiens tolloid-like 2 protein.
Length = 1015
Score = 45.6 bits (103), Expect = 0.001
Identities = 18/33 (54%), Positives = 19/33 (57%)
Query: 571 DNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
D+GGC H C N Y C C G EL ADKK C
Sbjct: 584 DHGGCEHRCVNTLGSYKCACDPGYELAADKKMC 616
Score = 41.5 bits (93), Expect = 0.018
Identities = 24/76 (31%), Positives = 33/76 (43%), Gaps = 2/76 (2%)
Query: 550 NMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAF 609
N + + FR + CA DNGGC H C N Y+C C G L + C EA
Sbjct: 718 NTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENGHDC--KEAG 775
Query: 610 LVYSRKNIIGRLSIKN 625
+ ++ G L+ N
Sbjct: 776 CAHKISSVEGTLASPN 791
Score = 37.5 bits (83), Expect = 0.29
Identities = 17/44 (38%), Positives = 23/44 (52%), Gaps = 4/44 (9%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSE 908
++C DNGGC H C+ T G Y C C Y L+++ C E
Sbjct: 734 DECAKDNGGCQHECVNTFG----SYLCRCRNGYWLHENGHDCKE 773
Score = 35.9 bits (79), Expect = 0.87
Identities = 16/37 (43%), Positives = 19/37 (51%), Gaps = 4/37 (10%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
D+GGC H C+ T G Y+CAC Y L D C
Sbjct: 584 DHGGCEHRCVNTLG----SYKCACDPGYELAADKKMC 616
>AL138765-2|CAI13580.1| 1015|Homo sapiens tolloid-like 2 protein.
Length = 1015
Score = 45.6 bits (103), Expect = 0.001
Identities = 18/33 (54%), Positives = 19/33 (57%)
Query: 571 DNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
D+GGC H C N Y C C G EL ADKK C
Sbjct: 584 DHGGCEHRCVNTLGSYKCACDPGYELAADKKMC 616
Score = 41.5 bits (93), Expect = 0.018
Identities = 24/76 (31%), Positives = 33/76 (43%), Gaps = 2/76 (2%)
Query: 550 NMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAF 609
N + + FR + CA DNGGC H C N Y+C C G L + C EA
Sbjct: 718 NTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENGHDC--KEAG 775
Query: 610 LVYSRKNIIGRLSIKN 625
+ ++ G L+ N
Sbjct: 776 CAHKISSVEGTLASPN 791
Score = 37.5 bits (83), Expect = 0.29
Identities = 17/44 (38%), Positives = 23/44 (52%), Gaps = 4/44 (9%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSE 908
++C DNGGC H C+ T G Y C C Y L+++ C E
Sbjct: 734 DECAKDNGGCQHECVNTFG----SYLCRCRNGYWLHENGHDCKE 773
Score = 35.9 bits (79), Expect = 0.87
Identities = 16/37 (43%), Positives = 19/37 (51%), Gaps = 4/37 (10%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
D+GGC H C+ T G Y+CAC Y L D C
Sbjct: 584 DHGGCEHRCVNTLG----SYKCACDPGYELAADKKMC 616
>AL136181-1|CAH72983.1| 1015|Homo sapiens tolloid-like 2 protein.
Length = 1015
Score = 45.6 bits (103), Expect = 0.001
Identities = 18/33 (54%), Positives = 19/33 (57%)
Query: 571 DNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
D+GGC H C N Y C C G EL ADKK C
Sbjct: 584 DHGGCEHRCVNTLGSYKCACDPGYELAADKKMC 616
Score = 41.5 bits (93), Expect = 0.018
Identities = 24/76 (31%), Positives = 33/76 (43%), Gaps = 2/76 (2%)
Query: 550 NMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAF 609
N + + FR + CA DNGGC H C N Y+C C G L + C EA
Sbjct: 718 NTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENGHDC--KEAG 775
Query: 610 LVYSRKNIIGRLSIKN 625
+ ++ G L+ N
Sbjct: 776 CAHKISSVEGTLASPN 791
Score = 37.5 bits (83), Expect = 0.29
Identities = 17/44 (38%), Positives = 23/44 (52%), Gaps = 4/44 (9%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSE 908
++C DNGGC H C+ T G Y C C Y L+++ C E
Sbjct: 734 DECAKDNGGCQHECVNTFG----SYLCRCRNGYWLHENGHDCKE 773
Score = 35.9 bits (79), Expect = 0.87
Identities = 16/37 (43%), Positives = 19/37 (51%), Gaps = 4/37 (10%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
D+GGC H C+ T G Y+CAC Y L D C
Sbjct: 584 DHGGCEHRCVNTLG----SYKCACDPGYELAADKKMC 616
>AF059516-1|AAD42979.1| 1015|Homo sapiens tolloid-like 2 protein
protein.
Length = 1015
Score = 45.6 bits (103), Expect = 0.001
Identities = 18/33 (54%), Positives = 19/33 (57%)
Query: 571 DNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
D+GGC H C N Y C C G EL ADKK C
Sbjct: 584 DHGGCEHRCVNTLGSYKCACDPGYELAADKKMC 616
Score = 41.5 bits (93), Expect = 0.018
Identities = 24/76 (31%), Positives = 33/76 (43%), Gaps = 2/76 (2%)
Query: 550 NMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAF 609
N + + FR + CA DNGGC H C N Y+C C G L + C EA
Sbjct: 718 NTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENGHDC--KEAG 775
Query: 610 LVYSRKNIIGRLSIKN 625
+ ++ G L+ N
Sbjct: 776 CAHKISSVEGTLASPN 791
Score = 37.5 bits (83), Expect = 0.29
Identities = 17/44 (38%), Positives = 23/44 (52%), Gaps = 4/44 (9%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSE 908
++C DNGGC H C+ T G Y C C Y L+++ C E
Sbjct: 734 DECAKDNGGCQHECVNTFG----SYLCRCRNGYWLHENGHDCKE 773
Score = 35.9 bits (79), Expect = 0.87
Identities = 16/37 (43%), Positives = 19/37 (51%), Gaps = 4/37 (10%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
D+GGC H C+ T G Y+CAC Y L D C
Sbjct: 584 DHGGCEHRCVNTLG----SYKCACDPGYELAADKKMC 616
>AB023149-1|BAA76776.2| 1078|Homo sapiens KIAA0932 protein protein.
Length = 1078
Score = 45.6 bits (103), Expect = 0.001
Identities = 18/33 (54%), Positives = 19/33 (57%)
Query: 571 DNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
D+GGC H C N Y C C G EL ADKK C
Sbjct: 647 DHGGCEHRCVNTLGSYKCACDPGYELAADKKMC 679
Score = 41.5 bits (93), Expect = 0.018
Identities = 24/76 (31%), Positives = 33/76 (43%), Gaps = 2/76 (2%)
Query: 550 NMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAF 609
N + + FR + CA DNGGC H C N Y+C C G L + C EA
Sbjct: 781 NTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENGHDC--KEAG 838
Query: 610 LVYSRKNIIGRLSIKN 625
+ ++ G L+ N
Sbjct: 839 CAHKISSVEGTLASPN 854
Score = 37.5 bits (83), Expect = 0.29
Identities = 17/44 (38%), Positives = 23/44 (52%), Gaps = 4/44 (9%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSE 908
++C DNGGC H C+ T G Y C C Y L+++ C E
Sbjct: 797 DECAKDNGGCQHECVNTFG----SYLCRCRNGYWLHENGHDCKE 836
Score = 35.9 bits (79), Expect = 0.87
Identities = 16/37 (43%), Positives = 19/37 (51%), Gaps = 4/37 (10%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
D+GGC H C+ T G Y+CAC Y L D C
Sbjct: 647 DHGGCEHRCVNTLG----SYKCACDPGYELAADKKMC 679
>U91963-1|AAB93878.1| 1013|Homo sapiens tolloid-like protein
protein.
Length = 1013
Score = 45.2 bits (102), Expect = 0.001
Identities = 21/58 (36%), Positives = 27/58 (46%)
Query: 550 NMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPE 607
N + K F+ + C+ DNGGC H C N Y+C C G L +K C E E
Sbjct: 716 NTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAE 773
Score = 38.3 bits (85), Expect = 0.16
Identities = 16/37 (43%), Positives = 19/37 (51%), Gaps = 1/37 (2%)
Query: 568 CAD-DNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA D GGC C N Y C C G EL D+++C
Sbjct: 578 CAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSC 614
Score = 37.9 bits (84), Expect = 0.22
Identities = 17/46 (36%), Positives = 23/46 (50%), Gaps = 4/46 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPE 910
++C DNGGC H C+ T G Y C C + L+ + C E E
Sbjct: 732 DECSKDNGGCQHECVNTMG----SYMCQCRNGFVLHDNKHDCKEAE 773
Score = 34.7 bits (76), Expect = 2.0
Identities = 16/37 (43%), Positives = 18/37 (48%), Gaps = 4/37 (10%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
D GGC CL T G Y+CAC Y L D +C
Sbjct: 582 DRGGCEQRCLNTLGS----YQCACEPGYELGPDRRSC 614
>AK123039-1|BAC85521.1| 971|Homo sapiens protein ( Homo sapiens
cDNA FLJ41044 fis, clone NT2RP7000466, highly similar
to Mus musculus CUB domain and EGF-like repeat
containing 1 (Cegf1). ).
Length = 971
Score = 45.2 bits (102), Expect = 0.001
Identities = 19/45 (42%), Positives = 25/45 (55%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFL 610
N C+ +NGGC +C N Y C C G +L +KK CVE + L
Sbjct: 405 NECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLL 449
Score = 44.0 bits (99), Expect = 0.003
Identities = 16/36 (44%), Positives = 20/36 (55%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
C NGGC H C N + CGC G +L D+K+C
Sbjct: 327 CQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSC 362
Score = 41.1 bits (92), Expect = 0.023
Identities = 15/37 (40%), Positives = 21/37 (56%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
C ++NGGC H C N Y C C G L+ ++ TC+
Sbjct: 132 CLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCI 168
Score = 41.1 bits (92), Expect = 0.023
Identities = 16/36 (44%), Positives = 19/36 (52%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA +NGGC C + C CP+G L D KTC
Sbjct: 286 CAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTC 321
Score = 40.3 bits (90), Expect = 0.041
Identities = 17/50 (34%), Positives = 27/50 (54%), Gaps = 4/50 (8%)
Query: 864 SNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFL 913
+N+C ++NGGC +C+ T G Y C C Y+L+ + C E + L
Sbjct: 404 TNECSINNGGCQQVCVNTVG----SYECQCHPGYKLHWNKKDCVEVKGLL 449
Score = 39.9 bits (89), Expect = 0.054
Identities = 17/45 (37%), Positives = 22/45 (48%), Gaps = 4/45 (8%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
C V+NGGC C D T C+CP + L D TC + +E
Sbjct: 286 CAVNNGGCDRTCK----DTSTGVHCSCPVGFTLQLDGKTCKDIDE 326
Score = 38.7 bits (86), Expect = 0.12
Identities = 20/50 (40%), Positives = 27/50 (54%), Gaps = 5/50 (10%)
Query: 865 NQCGVD-NGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFL 913
++CG + NGGC H CL PG +YRC C + L D C + +E L
Sbjct: 88 DECGNELNGGCVHDCLNIPG----NYRCTCFDGFMLAHDGHNCLDVDECL 133
Score = 37.5 bits (83), Expect = 0.29
Identities = 17/44 (38%), Positives = 23/44 (52%), Gaps = 1/44 (2%)
Query: 568 CADD-NGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFL 610
C ++ NGGC H C N P +Y C C G L D C++ + L
Sbjct: 90 CGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECL 133
Score = 36.3 bits (80), Expect = 0.66
Identities = 19/63 (30%), Positives = 28/63 (44%), Gaps = 2/63 (3%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISL 319
C +NN GC H C+ Y C C G L +N T + S + L + + S I
Sbjct: 132 CLENNGGCQHTCVNVMG--SYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICK 189
Query: 320 DSP 322
++P
Sbjct: 190 EAP 192
Score = 36.3 bits (80), Expect = 0.66
Identities = 16/48 (33%), Positives = 23/48 (47%), Gaps = 4/48 (8%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL 914
C NGGC H C D C+C Y+++ D +C E E+ +L
Sbjct: 217 CNHGNGGCQHSC----DDTADGPECSCHPQYKMHTDGRSCLEREDTVL 260
Score = 35.5 bits (78), Expect = 1.2
Identities = 14/40 (35%), Positives = 20/40 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPE 607
C NGGC H C + D C C ++ D ++C+E E
Sbjct: 217 CNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLERE 256
Score = 34.3 bits (75), Expect = 2.7
Identities = 13/38 (34%), Positives = 21/38 (55%), Gaps = 1/38 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYI-CGCPLGLELTADKKTCV 604
C + + GCSH+C P + C C G EL +++ C+
Sbjct: 177 CMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCI 214
Score = 33.9 bits (74), Expect = 3.5
Identities = 15/47 (31%), Positives = 23/47 (48%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
++C +NGGC H C+ +V Y C C + L+ + TC E
Sbjct: 130 DECLENNGGCQHTCV----NVMGSYECCCKEGFFLSDNQHTCIHRSE 172
Score = 33.9 bits (74), Expect = 3.5
Identities = 14/47 (29%), Positives = 22/47 (46%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
++C NGGC H C G + C C ++L D +C + +E
Sbjct: 325 DECQTRNGGCDHFCKNIVG----SFDCGCKKGFKLLTDEKSCQDVDE 367
>AJ400877-1|CAB92285.1| 999|Homo sapiens CEGP1 protein protein.
Length = 999
Score = 45.2 bits (102), Expect = 0.001
Identities = 19/45 (42%), Positives = 25/45 (55%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFL 610
N C+ +NGGC +C N Y C C G +L +KK CVE + L
Sbjct: 405 NECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLL 449
Score = 44.0 bits (99), Expect = 0.003
Identities = 16/36 (44%), Positives = 20/36 (55%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
C NGGC H C N + CGC G +L D+K+C
Sbjct: 327 CQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSC 362
Score = 41.1 bits (92), Expect = 0.023
Identities = 15/37 (40%), Positives = 21/37 (56%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
C ++NGGC H C N Y C C G L+ ++ TC+
Sbjct: 132 CLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCI 168
Score = 41.1 bits (92), Expect = 0.023
Identities = 16/36 (44%), Positives = 19/36 (52%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA +NGGC C + C CP+G L D KTC
Sbjct: 286 CAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTC 321
Score = 40.3 bits (90), Expect = 0.041
Identities = 17/50 (34%), Positives = 27/50 (54%), Gaps = 4/50 (8%)
Query: 864 SNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFL 913
+N+C ++NGGC +C+ T G Y C C Y+L+ + C E + L
Sbjct: 404 TNECSINNGGCQQVCVNTVG----SYECQCHPGYKLHWNKKDCVEVKGLL 449
Score = 39.9 bits (89), Expect = 0.054
Identities = 17/45 (37%), Positives = 22/45 (48%), Gaps = 4/45 (8%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
C V+NGGC C D T C+CP + L D TC + +E
Sbjct: 286 CAVNNGGCDRTCK----DTSTGVHCSCPVGFTLQLDGKTCKDIDE 326
Score = 38.7 bits (86), Expect = 0.12
Identities = 20/50 (40%), Positives = 27/50 (54%), Gaps = 5/50 (10%)
Query: 865 NQCGVD-NGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFL 913
++CG + NGGC H CL PG +YRC C + L D C + +E L
Sbjct: 88 DECGNELNGGCVHDCLNIPG----NYRCTCFDGFMLAHDGHNCLDVDECL 133
Score = 37.5 bits (83), Expect = 0.29
Identities = 17/44 (38%), Positives = 23/44 (52%), Gaps = 1/44 (2%)
Query: 568 CADD-NGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFL 610
C ++ NGGC H C N P +Y C C G L D C++ + L
Sbjct: 90 CGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECL 133
Score = 36.3 bits (80), Expect = 0.66
Identities = 19/63 (30%), Positives = 28/63 (44%), Gaps = 2/63 (3%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISL 319
C +NN GC H C+ Y C C G L +N T + S + L + + S I
Sbjct: 132 CLENNGGCQHTCVNVMG--SYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICK 189
Query: 320 DSP 322
++P
Sbjct: 190 EAP 192
Score = 36.3 bits (80), Expect = 0.66
Identities = 16/48 (33%), Positives = 23/48 (47%), Gaps = 4/48 (8%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL 914
C NGGC H C D C+C Y+++ D +C E E+ +L
Sbjct: 217 CNHGNGGCQHSC----DDTADGPECSCHPQYKMHTDGRSCLEREDTVL 260
Score = 35.5 bits (78), Expect = 1.2
Identities = 14/40 (35%), Positives = 20/40 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPE 607
C NGGC H C + D C C ++ D ++C+E E
Sbjct: 217 CNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLERE 256
Score = 34.3 bits (75), Expect = 2.7
Identities = 13/38 (34%), Positives = 21/38 (55%), Gaps = 1/38 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYI-CGCPLGLELTADKKTCV 604
C + + GCSH+C P + C C G EL +++ C+
Sbjct: 177 CMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCI 214
Score = 33.9 bits (74), Expect = 3.5
Identities = 15/47 (31%), Positives = 23/47 (48%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
++C +NGGC H C+ +V Y C C + L+ + TC E
Sbjct: 130 DECLENNGGCQHTCV----NVMGSYECCCKEGFFLSDNQHTCIHRSE 172
Score = 33.9 bits (74), Expect = 3.5
Identities = 14/47 (29%), Positives = 22/47 (46%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
++C NGGC H C G + C C ++L D +C + +E
Sbjct: 325 DECQTRNGGCDHFCKNIVG----SFDCGCKKGFKLLTDEKSCQDVDE 367
>AF282732-1|AAF86287.1| 1013|Homo sapiens tolloid-like protein
protein.
Length = 1013
Score = 45.2 bits (102), Expect = 0.001
Identities = 21/58 (36%), Positives = 27/58 (46%)
Query: 550 NMMGVKAFRLGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPE 607
N + K F+ + C+ DNGGC H C N Y+C C G L +K C E E
Sbjct: 716 NTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAE 773
Score = 38.3 bits (85), Expect = 0.16
Identities = 16/37 (43%), Positives = 19/37 (51%), Gaps = 1/37 (2%)
Query: 568 CAD-DNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA D GGC C N Y C C G EL D+++C
Sbjct: 578 CAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSC 614
Score = 37.9 bits (84), Expect = 0.22
Identities = 17/46 (36%), Positives = 23/46 (50%), Gaps = 4/46 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPE 910
++C DNGGC H C+ T G Y C C + L+ + C E E
Sbjct: 732 DECSKDNGGCQHECVNTMG----SYMCQCRNGFVLHDNKHDCKEAE 773
Score = 34.7 bits (76), Expect = 2.0
Identities = 16/37 (43%), Positives = 18/37 (48%), Gaps = 4/37 (10%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
D GGC CL T G Y+CAC Y L D +C
Sbjct: 582 DRGGCEQRCLNTLGS----YQCACEPGYELGPDRRSC 614
>Z98880-3|CAI42375.1| 2341|Homo sapiens v-ros UR2 sarcoma virus
oncogene homolog 1 (avian) protein.
Length = 2341
Score = 44.8 bits (101), Expect = 0.002
Identities = 48/190 (25%), Positives = 77/190 (40%), Gaps = 17/190 (8%)
Query: 625 NEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVEG 684
N + D+ VS + Y + LY+SD+K +NG+ + + +
Sbjct: 687 NSFGPGEFLSSDIGNVSDMDWY--NNSLYYSDTKGDVFVWL-LNGTDISENYHLPSIAGA 743
Query: 685 --LAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
LA +W G +YW T S L G + I+ +V+D GY+YW+ L
Sbjct: 744 GALAFEWLGHFLYWAGKTYVIQRQSVLTGHTD--IVTHVKLLVNDMVVDSVGGYLYWTTL 801
Query: 743 GSKSIKRAAMDGSSVSVFMEQV----GRVHALAIDYERRAIYWAALDPPVVEF--AFLNG 796
S++ ++G S V Q +V AL +D +YW D + A L G
Sbjct: 802 --YSVESTRLNGESSLVLQTQPWFSGKKVIALTLDLSDGLLYWLVQDSQCIHLYTAVLRG 859
Query: 797 --TGRQTLAD 804
TG T+ +
Sbjct: 860 QSTGDTTITE 869
Score = 34.7 bits (76), Expect = 2.0
Identities = 25/103 (24%), Positives = 52/103 (50%), Gaps = 3/103 (2%)
Query: 294 SSTTCYDSPQMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRTLT-VDFDPKTEYIYWA 352
+S++ + L +++++++ K SL + L L + +T + D + +Y++
Sbjct: 290 TSSSAVQQEEQWLFLSRKTSLRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVYFS 349
Query: 353 DGLAKTISKAR--LDGSDQSVVVRSSGVPDSIAIDPLSRKIYW 393
+G KA D SD + R SG+ SI+ID L +++Y+
Sbjct: 350 EGTLIWAKKAANMSDVSDLRIFYRGSGLISSISIDWLYQRMYF 392
Score = 34.3 bits (75), Expect = 2.7
Identities = 34/150 (22%), Positives = 67/150 (44%), Gaps = 9/150 (6%)
Query: 596 LTADKKTCVEPEAFLVYSRKNIIGRLSIKNEYNDAVIPIKDL--KEVSALALYVSGSKLY 653
+T + E +L SRK + + S+K+ ++A D ++ +++ V +Y
Sbjct: 288 ITTSSSAVQQEEQWLFLSRKTSLRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVY 347
Query: 654 WSDSKTKTINRCSVNGSAVEKI---VEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLD 710
+S+ T + + N S V + GL+ ++IDW Q +Y+ + + V L+
Sbjct: 348 FSEG-TLIWAKKAANMSDVSDLRIFYRGSGLISSISIDWLYQRMYF--IMDELVCVCDLE 404
Query: 711 GSSR-RAIIWQGLKKPKSIVLDPKKGYMYW 739
S I + P+ IV D GY+++
Sbjct: 405 NCSNIEEITPPSISAPQKIVADSYNGYVFY 434
>Z98880-2|CAI42374.1| 2347|Homo sapiens v-ros UR2 sarcoma virus
oncogene homolog 1 (avian) protein.
Length = 2347
Score = 44.8 bits (101), Expect = 0.002
Identities = 48/190 (25%), Positives = 77/190 (40%), Gaps = 17/190 (8%)
Query: 625 NEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVEG 684
N + D+ VS + Y + LY+SD+K +NG+ + + +
Sbjct: 692 NSFGPGEFLSSDIGNVSDMDWY--NNSLYYSDTKGDVFVWL-LNGTDISENYHLPSIAGA 748
Query: 685 --LAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
LA +W G +YW T S L G + I+ +V+D GY+YW+ L
Sbjct: 749 GALAFEWLGHFLYWAGKTYVIQRQSVLTGHTD--IVTHVKLLVNDMVVDSVGGYLYWTTL 806
Query: 743 GSKSIKRAAMDGSSVSVFMEQV----GRVHALAIDYERRAIYWAALDPPVVEF--AFLNG 796
S++ ++G S V Q +V AL +D +YW D + A L G
Sbjct: 807 --YSVESTRLNGESSLVLQTQPWFSGKKVIALTLDLSDGLLYWLVQDSQCIHLYTAVLRG 864
Query: 797 --TGRQTLAD 804
TG T+ +
Sbjct: 865 QSTGDTTITE 874
Score = 34.7 bits (76), Expect = 2.0
Identities = 25/103 (24%), Positives = 52/103 (50%), Gaps = 3/103 (2%)
Query: 294 SSTTCYDSPQMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRTLT-VDFDPKTEYIYWA 352
+S++ + L +++++++ K SL + L L + +T + D + +Y++
Sbjct: 281 TSSSAVQQEEQWLFLSRKTSLRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVYFS 340
Query: 353 DGLAKTISKAR--LDGSDQSVVVRSSGVPDSIAIDPLSRKIYW 393
+G KA D SD + R SG+ SI+ID L +++Y+
Sbjct: 341 EGTLIWAKKAANMSDVSDLRIFYRGSGLISSISIDWLYQRMYF 383
Score = 34.3 bits (75), Expect = 2.7
Identities = 34/150 (22%), Positives = 67/150 (44%), Gaps = 9/150 (6%)
Query: 596 LTADKKTCVEPEAFLVYSRKNIIGRLSIKNEYNDAVIPIKDL--KEVSALALYVSGSKLY 653
+T + E +L SRK + + S+K+ ++A D ++ +++ V +Y
Sbjct: 279 ITTSSSAVQQEEQWLFLSRKTSLRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVY 338
Query: 654 WSDSKTKTINRCSVNGSAVEKI---VEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLD 710
+S+ T + + N S V + GL+ ++IDW Q +Y+ + + V L+
Sbjct: 339 FSEG-TLIWAKKAANMSDVSDLRIFYRGSGLISSISIDWLYQRMYF--IMDELVCVCDLE 395
Query: 711 GSSR-RAIIWQGLKKPKSIVLDPKKGYMYW 739
S I + P+ IV D GY+++
Sbjct: 396 NCSNIEEITPPSISAPQKIVADSYNGYVFY 425
>M34353-1|AAA60278.1| 2347|Homo sapiens ROS1 protein.
Length = 2347
Score = 44.8 bits (101), Expect = 0.002
Identities = 48/190 (25%), Positives = 77/190 (40%), Gaps = 17/190 (8%)
Query: 625 NEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVEG 684
N + D+ VS + Y + LY+SD+K +NG+ + + +
Sbjct: 692 NSFGPGEFLSSDIGNVSDMDWY--NNSLYYSDTKGDVFVWL-LNGTDISENYHLPSIAGA 748
Query: 685 --LAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
LA +W G +YW T S L G + I+ +V+D GY+YW+ L
Sbjct: 749 GALAFEWLGHFLYWAGKTYVIQRQSVLTGHTD--IVTHVKLLVNDMVVDSVGGYLYWTTL 806
Query: 743 GSKSIKRAAMDGSSVSVFMEQV----GRVHALAIDYERRAIYWAALDPPVVEF--AFLNG 796
S++ ++G S V Q +V AL +D +YW D + A L G
Sbjct: 807 --YSVESTRLNGESSLVLQTQPWFSGKKVIALTLDLSDGLLYWLVQDSQCIHLYTAVLRG 864
Query: 797 --TGRQTLAD 804
TG T+ +
Sbjct: 865 QSTGDTTITE 874
Score = 34.7 bits (76), Expect = 2.0
Identities = 25/103 (24%), Positives = 52/103 (50%), Gaps = 3/103 (2%)
Query: 294 SSTTCYDSPQMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRTLT-VDFDPKTEYIYWA 352
+S++ + L +++++++ K SL + L L + +T + D + +Y++
Sbjct: 281 TSSSAVQQEEQWLFLSRKTSLRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVYFS 340
Query: 353 DGLAKTISKAR--LDGSDQSVVVRSSGVPDSIAIDPLSRKIYW 393
+G KA D SD + R SG+ SI+ID L +++Y+
Sbjct: 341 EGTLIWAKKAANMSDVSDLRIFYRGSGLISSISIDWLYQRMYF 383
Score = 34.3 bits (75), Expect = 2.7
Identities = 34/150 (22%), Positives = 67/150 (44%), Gaps = 9/150 (6%)
Query: 596 LTADKKTCVEPEAFLVYSRKNIIGRLSIKNEYNDAVIPIKDL--KEVSALALYVSGSKLY 653
+T + E +L SRK + + S+K+ ++A D ++ +++ V +Y
Sbjct: 279 ITTSSSAVQQEEQWLFLSRKTSLRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVY 338
Query: 654 WSDSKTKTINRCSVNGSAVEKI---VEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLD 710
+S+ T + + N S V + GL+ ++IDW Q +Y+ + + V L+
Sbjct: 339 FSEG-TLIWAKKAANMSDVSDLRIFYRGSGLISSISIDWLYQRMYF--IMDELVCVCDLE 395
Query: 711 GSSR-RAIIWQGLKKPKSIVLDPKKGYMYW 739
S I + P+ IV D GY+++
Sbjct: 396 NCSNIEEITPPSISAPQKIVADSYNGYVFY 425
>BC105633-1|AAI05634.1| 757|Homo sapiens tumor endothelial marker
1, precursor protein.
Length = 757
Score = 44.8 bits (101), Expect = 0.002
Identities = 17/40 (42%), Positives = 23/40 (57%), Gaps = 1/40 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYI-CGCPLGLELTADKKTCVEP 606
C+ DNGGC H C D ++ C C G L AD ++C +P
Sbjct: 235 CSPDNGGCEHECVEEVDGHVSCRCTEGFRLAADGRSCEDP 274
Score = 37.1 bits (82), Expect = 0.38
Identities = 16/43 (37%), Positives = 21/43 (48%), Gaps = 3/43 (6%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEP 909
C DNGGC H C+ +V C C +RL D +C +P
Sbjct: 235 CSPDNGGCEHECVE---EVDGHVSCRCTEGFRLAADGRSCEDP 274
>BC104484-1|AAI04485.1| 757|Homo sapiens tumor endothelial marker
1, precursor protein.
Length = 757
Score = 44.8 bits (101), Expect = 0.002
Identities = 17/40 (42%), Positives = 23/40 (57%), Gaps = 1/40 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYI-CGCPLGLELTADKKTCVEP 606
C+ DNGGC H C D ++ C C G L AD ++C +P
Sbjct: 235 CSPDNGGCEHECVEEVDGHVSCRCTEGFRLAADGRSCEDP 274
Score = 37.1 bits (82), Expect = 0.38
Identities = 16/43 (37%), Positives = 21/43 (48%), Gaps = 3/43 (6%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEP 909
C DNGGC H C+ +V C C +RL D +C +P
Sbjct: 235 CSPDNGGCEHECVE---EVDGHVSCRCTEGFRLAADGRSCEDP 274
>BC051340-1|AAH51340.1| 757|Homo sapiens CD248 molecule, endosialin
protein.
Length = 757
Score = 44.8 bits (101), Expect = 0.002
Identities = 17/40 (42%), Positives = 23/40 (57%), Gaps = 1/40 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYI-CGCPLGLELTADKKTCVEP 606
C+ DNGGC H C D ++ C C G L AD ++C +P
Sbjct: 235 CSPDNGGCEHECVEEVDGHVSCRCTEGFRLAADGRSCEDP 274
Score = 37.1 bits (82), Expect = 0.38
Identities = 16/43 (37%), Positives = 21/43 (48%), Gaps = 3/43 (6%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEP 909
C DNGGC H C+ +V C C +RL D +C +P
Sbjct: 235 CSPDNGGCEHECVE---EVDGHVSCRCTEGFRLAADGRSCEDP 274
>AL132671-5|CAI23378.1| 2347|Homo sapiens v-ros UR2 sarcoma virus
oncogene homolog 1 (avian) protein.
Length = 2347
Score = 44.8 bits (101), Expect = 0.002
Identities = 48/190 (25%), Positives = 77/190 (40%), Gaps = 17/190 (8%)
Query: 625 NEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVEG 684
N + D+ VS + Y + LY+SD+K +NG+ + + +
Sbjct: 692 NSFGPGEFLSSDIGNVSDMDWY--NNSLYYSDTKGDVFVWL-LNGTDISENYHLPSIAGA 748
Query: 685 --LAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
LA +W G +YW T S L G + I+ +V+D GY+YW+ L
Sbjct: 749 GALAFEWLGHFLYWAGKTYVIQRQSVLTGHTD--IVTHVKLLVNDMVVDSVGGYLYWTTL 806
Query: 743 GSKSIKRAAMDGSSVSVFMEQV----GRVHALAIDYERRAIYWAALDPPVVEF--AFLNG 796
S++ ++G S V Q +V AL +D +YW D + A L G
Sbjct: 807 --YSVESTRLNGESSLVLQTQPWFSGKKVIALTLDLSDGLLYWLVQDSQCIHLYTAVLRG 864
Query: 797 --TGRQTLAD 804
TG T+ +
Sbjct: 865 QSTGDTTITE 874
Score = 34.7 bits (76), Expect = 2.0
Identities = 25/103 (24%), Positives = 52/103 (50%), Gaps = 3/103 (2%)
Query: 294 SSTTCYDSPQMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRTLT-VDFDPKTEYIYWA 352
+S++ + L +++++++ K SL + L L + +T + D + +Y++
Sbjct: 281 TSSSAVQQEEQWLFLSRKTSLRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVYFS 340
Query: 353 DGLAKTISKAR--LDGSDQSVVVRSSGVPDSIAIDPLSRKIYW 393
+G KA D SD + R SG+ SI+ID L +++Y+
Sbjct: 341 EGTLIWAKKAANMSDVSDLRIFYRGSGLISSISIDWLYQRMYF 383
Score = 34.3 bits (75), Expect = 2.7
Identities = 34/150 (22%), Positives = 67/150 (44%), Gaps = 9/150 (6%)
Query: 596 LTADKKTCVEPEAFLVYSRKNIIGRLSIKNEYNDAVIPIKDL--KEVSALALYVSGSKLY 653
+T + E +L SRK + + S+K+ ++A D ++ +++ V +Y
Sbjct: 279 ITTSSSAVQQEEQWLFLSRKTSLRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVY 338
Query: 654 WSDSKTKTINRCSVNGSAVEKI---VEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLD 710
+S+ T + + N S V + GL+ ++IDW Q +Y+ + + V L+
Sbjct: 339 FSEG-TLIWAKKAANMSDVSDLRIFYRGSGLISSISIDWLYQRMYF--IMDELVCVCDLE 395
Query: 711 GSSR-RAIIWQGLKKPKSIVLDPKKGYMYW 739
S I + P+ IV D GY+++
Sbjct: 396 NCSNIEEITPPSISAPQKIVADSYNGYVFY 425
>AL132671-4|CAI23379.1| 2341|Homo sapiens v-ros UR2 sarcoma virus
oncogene homolog 1 (avian) protein.
Length = 2341
Score = 44.8 bits (101), Expect = 0.002
Identities = 48/190 (25%), Positives = 77/190 (40%), Gaps = 17/190 (8%)
Query: 625 NEYNDAVIPIKDLKEVSALALYVSGSKLYWSDSKTKTINRCSVNGSAVEKIVEWLGLVEG 684
N + D+ VS + Y + LY+SD+K +NG+ + + +
Sbjct: 687 NSFGPGEFLSSDIGNVSDMDWY--NNSLYYSDTKGDVFVWL-LNGTDISENYHLPSIAGA 743
Query: 685 --LAIDWSGQNIYWTDTTTQRIEVSRLDGSSRRAIIWQGLKKPKSIVLDPKKGYMYWSEL 742
LA +W G +YW T S L G + I+ +V+D GY+YW+ L
Sbjct: 744 GALAFEWLGHFLYWAGKTYVIQRQSVLTGHTD--IVTHVKLLVNDMVVDSVGGYLYWTTL 801
Query: 743 GSKSIKRAAMDGSSVSVFMEQV----GRVHALAIDYERRAIYWAALDPPVVEF--AFLNG 796
S++ ++G S V Q +V AL +D +YW D + A L G
Sbjct: 802 --YSVESTRLNGESSLVLQTQPWFSGKKVIALTLDLSDGLLYWLVQDSQCIHLYTAVLRG 859
Query: 797 --TGRQTLAD 804
TG T+ +
Sbjct: 860 QSTGDTTITE 869
Score = 34.7 bits (76), Expect = 2.0
Identities = 25/103 (24%), Positives = 52/103 (50%), Gaps = 3/103 (2%)
Query: 294 SSTTCYDSPQMLLVVAQRSTISKISLDSPDFTPYTLPLKDLKRTLT-VDFDPKTEYIYWA 352
+S++ + L +++++++ K SL + L L + +T + D + +Y++
Sbjct: 290 TSSSAVQQEEQWLFLSRKTSLRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVYFS 349
Query: 353 DGLAKTISKAR--LDGSDQSVVVRSSGVPDSIAIDPLSRKIYW 393
+G KA D SD + R SG+ SI+ID L +++Y+
Sbjct: 350 EGTLIWAKKAANMSDVSDLRIFYRGSGLISSISIDWLYQRMYF 392
Score = 34.3 bits (75), Expect = 2.7
Identities = 34/150 (22%), Positives = 67/150 (44%), Gaps = 9/150 (6%)
Query: 596 LTADKKTCVEPEAFLVYSRKNIIGRLSIKNEYNDAVIPIKDL--KEVSALALYVSGSKLY 653
+T + E +L SRK + + S+K+ ++A D ++ +++ V +Y
Sbjct: 288 ITTSSSAVQQEEQWLFLSRKTSLRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVY 347
Query: 654 WSDSKTKTINRCSVNGSAVEKI---VEWLGLVEGLAIDWSGQNIYWTDTTTQRIEVSRLD 710
+S+ T + + N S V + GL+ ++IDW Q +Y+ + + V L+
Sbjct: 348 FSEG-TLIWAKKAANMSDVSDLRIFYRGSGLISSISIDWLYQRMYF--IMDELVCVCDLE 404
Query: 711 GSSR-RAIIWQGLKKPKSIVLDPKKGYMYW 739
S I + P+ IV D GY+++
Sbjct: 405 NCSNIEEITPPSISAPQKIVADSYNGYVFY 434
>AJ295846-1|CAC34381.1| 757|Homo sapiens endosialin protein
protein.
Length = 757
Score = 44.8 bits (101), Expect = 0.002
Identities = 17/40 (42%), Positives = 23/40 (57%), Gaps = 1/40 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYI-CGCPLGLELTADKKTCVEP 606
C+ DNGGC H C D ++ C C G L AD ++C +P
Sbjct: 235 CSPDNGGCEHECVEEVDGHVSCRCTEGFRLAADGRSCEDP 274
Score = 37.1 bits (82), Expect = 0.38
Identities = 16/43 (37%), Positives = 21/43 (48%), Gaps = 3/43 (6%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEP 909
C DNGGC H C+ +V C C +RL D +C +P
Sbjct: 235 CSPDNGGCEHECVE---EVDGHVSCRCTEGFRLAADGRSCEDP 274
>AF279142-1|AAG00867.1| 757|Homo sapiens tumor endothelial marker 1
precursor protein.
Length = 757
Score = 44.8 bits (101), Expect = 0.002
Identities = 17/40 (42%), Positives = 23/40 (57%), Gaps = 1/40 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYI-CGCPLGLELTADKKTCVEP 606
C+ DNGGC H C D ++ C C G L AD ++C +P
Sbjct: 235 CSPDNGGCEHECVEEVDGHVSCRCTEGFRLAADGRSCEDP 274
Score = 37.1 bits (82), Expect = 0.38
Identities = 16/43 (37%), Positives = 21/43 (48%), Gaps = 3/43 (6%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEP 909
C DNGGC H C+ +V C C +RL D +C +P
Sbjct: 235 CSPDNGGCEHECVE---EVDGHVSCRCTEGFRLAADGRSCEDP 274
>BC030532-1|AAH30532.1| 855|Homo sapiens suppression of
tumorigenicity 14 (colon carcinoma) protein.
Length = 855
Score = 44.4 bits (100), Expect = 0.002
Identities = 30/87 (34%), Positives = 38/87 (43%), Gaps = 24/87 (27%)
Query: 1094 SRQCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEG 1153
S+QC+G+ DC DG DEA C V C T +RC G
Sbjct: 541 SQQCNGKDDCGDGSDEASCPKVNV-VTCTKHT----------------------YRCLNG 577
Query: 1154 LCIA-ARFVCDGRPQCADGSDEAPAAC 1179
LC++ CDG+ C+DGSDE C
Sbjct: 578 LCLSKGNPECDGKEDCSDGSDEKDCDC 604
Score = 42.3 bits (95), Expect = 0.010
Identities = 25/88 (28%), Positives = 31/88 (35%), Gaps = 8/88 (9%)
Query: 1096 QCDGQQDCEDGRDEAECGA-CGGDVRCADG-------TXXXXXXXXXXXXXXXXXXXXDA 1147
+CDG DC D DE C G C +
Sbjct: 470 RCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQT 529
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEA 1175
FRC G C++ C+G+ C DGSDEA
Sbjct: 530 FRCSNGKCLSKSQQCNGKDDCGDGSDEA 557
Score = 38.3 bits (85), Expect = 0.16
Identities = 16/36 (44%), Positives = 17/36 (47%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAACAYGH 1183
F C G CI CDG C D SDE +C GH
Sbjct: 457 FTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGH 492
Score = 34.7 bits (76), Expect = 2.0
Identities = 12/21 (57%), Positives = 16/21 (76%), Gaps = 1/21 (4%)
Query: 1096 QCDGQQDCEDGRDEAECGACG 1116
+CDG++DC DG DE +C CG
Sbjct: 586 ECDGKEDCSDGSDEKDCD-CG 605
>BC018146-1|AAH18146.1| 422|Homo sapiens ST14 protein protein.
Length = 422
Score = 44.4 bits (100), Expect = 0.002
Identities = 30/87 (34%), Positives = 38/87 (43%), Gaps = 24/87 (27%)
Query: 1094 SRQCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEG 1153
S+QC+G+ DC DG DEA C V C T +RC G
Sbjct: 108 SQQCNGKDDCGDGSDEASCPKVNV-VTCTKHT----------------------YRCLNG 144
Query: 1154 LCIA-ARFVCDGRPQCADGSDEAPAAC 1179
LC++ CDG+ C+DGSDE C
Sbjct: 145 LCLSKGNPECDGKEDCSDGSDEKDCDC 171
Score = 42.3 bits (95), Expect = 0.010
Identities = 25/88 (28%), Positives = 31/88 (35%), Gaps = 8/88 (9%)
Query: 1096 QCDGQQDCEDGRDEAECGA-CGGDVRCADG-------TXXXXXXXXXXXXXXXXXXXXDA 1147
+CDG DC D DE C G C +
Sbjct: 37 RCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQT 96
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEA 1175
FRC G C++ C+G+ C DGSDEA
Sbjct: 97 FRCSNGKCLSKSQQCNGKDDCGDGSDEA 124
Score = 38.3 bits (85), Expect = 0.16
Identities = 16/36 (44%), Positives = 17/36 (47%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAACAYGH 1183
F C G CI CDG C D SDE +C GH
Sbjct: 24 FTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGH 59
Score = 34.7 bits (76), Expect = 2.0
Identities = 12/21 (57%), Positives = 16/21 (76%), Gaps = 1/21 (4%)
Query: 1096 QCDGQQDCEDGRDEAECGACG 1116
+CDG++DC DG DE +C CG
Sbjct: 153 ECDGKEDCSDGSDEKDCD-CG 172
>BC005826-1|AAH05826.2| 526|Homo sapiens ST14 protein protein.
Length = 526
Score = 44.4 bits (100), Expect = 0.002
Identities = 30/87 (34%), Positives = 38/87 (43%), Gaps = 24/87 (27%)
Query: 1094 SRQCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEG 1153
S+QC+G+ DC DG DEA C V C T +RC G
Sbjct: 212 SQQCNGKDDCGDGSDEASCPKVNV-VTCTKHT----------------------YRCLNG 248
Query: 1154 LCIA-ARFVCDGRPQCADGSDEAPAAC 1179
LC++ CDG+ C+DGSDE C
Sbjct: 249 LCLSKGNPECDGKEDCSDGSDEKDCDC 275
Score = 42.3 bits (95), Expect = 0.010
Identities = 25/88 (28%), Positives = 31/88 (35%), Gaps = 8/88 (9%)
Query: 1096 QCDGQQDCEDGRDEAECGA-CGGDVRCADG-------TXXXXXXXXXXXXXXXXXXXXDA 1147
+CDG DC D DE C G C +
Sbjct: 141 RCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQT 200
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEA 1175
FRC G C++ C+G+ C DGSDEA
Sbjct: 201 FRCSNGKCLSKSQQCNGKDDCGDGSDEA 228
Score = 38.3 bits (85), Expect = 0.16
Identities = 16/36 (44%), Positives = 17/36 (47%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAACAYGH 1183
F C G CI CDG C D SDE +C GH
Sbjct: 128 FTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGH 163
Score = 34.7 bits (76), Expect = 2.0
Identities = 12/21 (57%), Positives = 16/21 (76%), Gaps = 1/21 (4%)
Query: 1096 QCDGQQDCEDGRDEAECGACG 1116
+CDG++DC DG DE +C CG
Sbjct: 257 ECDGKEDCSDGSDEKDCD-CG 276
>AF283256-1|AAG13949.1| 325|Homo sapiens serine protease SNC19
protein.
Length = 325
Score = 44.4 bits (100), Expect = 0.002
Identities = 30/87 (34%), Positives = 38/87 (43%), Gaps = 24/87 (27%)
Query: 1094 SRQCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEG 1153
S+QC+G+ DC DG DEA C V C T +RC G
Sbjct: 202 SQQCNGKDDCGDGSDEASCPKVNV-VTCTKHT----------------------YRCLNG 238
Query: 1154 LCIA-ARFVCDGRPQCADGSDEAPAAC 1179
LC++ CDG+ C+DGSDE C
Sbjct: 239 LCLSKGNPECDGKEDCSDGSDEKDCDC 265
Score = 42.3 bits (95), Expect = 0.010
Identities = 25/88 (28%), Positives = 31/88 (35%), Gaps = 8/88 (9%)
Query: 1096 QCDGQQDCEDGRDEAECGA-CGGDVRCADG-------TXXXXXXXXXXXXXXXXXXXXDA 1147
+CDG DC D DE C G C +
Sbjct: 131 RCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQT 190
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEA 1175
FRC G C++ C+G+ C DGSDEA
Sbjct: 191 FRCSNGKCLSKSQQCNGKDDCGDGSDEA 218
Score = 38.3 bits (85), Expect = 0.16
Identities = 16/36 (44%), Positives = 17/36 (47%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAACAYGH 1183
F C G CI CDG C D SDE +C GH
Sbjct: 118 FTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGH 153
Score = 34.7 bits (76), Expect = 2.0
Identities = 12/21 (57%), Positives = 16/21 (76%), Gaps = 1/21 (4%)
Query: 1096 QCDGQQDCEDGRDEAECGACG 1116
+CDG++DC DG DE +C CG
Sbjct: 247 ECDGKEDCSDGSDEKDCD-CG 266
>AF133086-1|AAF00109.1| 855|Homo sapiens membrane-type serine
protease 1 protein.
Length = 855
Score = 44.4 bits (100), Expect = 0.002
Identities = 30/87 (34%), Positives = 38/87 (43%), Gaps = 24/87 (27%)
Query: 1094 SRQCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEG 1153
S+QC+G+ DC DG DEA C V C T +RC G
Sbjct: 541 SQQCNGKDDCGDGSDEASCPKVNV-VTCTKHT----------------------YRCLNG 577
Query: 1154 LCIA-ARFVCDGRPQCADGSDEAPAAC 1179
LC++ CDG+ C+DGSDE C
Sbjct: 578 LCLSKGNPECDGKEDCSDGSDEKDCDC 604
Score = 42.3 bits (95), Expect = 0.010
Identities = 25/88 (28%), Positives = 31/88 (35%), Gaps = 8/88 (9%)
Query: 1096 QCDGQQDCEDGRDEAECGA-CGGDVRCADG-------TXXXXXXXXXXXXXXXXXXXXDA 1147
+CDG DC D DE C G C +
Sbjct: 470 RCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQT 529
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEA 1175
FRC G C++ C+G+ C DGSDEA
Sbjct: 530 FRCSNGKCLSKSQQCNGKDDCGDGSDEA 557
Score = 38.3 bits (85), Expect = 0.16
Identities = 16/36 (44%), Positives = 17/36 (47%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAACAYGH 1183
F C G CI CDG C D SDE +C GH
Sbjct: 457 FTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGH 492
Score = 34.7 bits (76), Expect = 2.0
Identities = 12/21 (57%), Positives = 16/21 (76%), Gaps = 1/21 (4%)
Query: 1096 QCDGQQDCEDGRDEAECGACG 1116
+CDG++DC DG DE +C CG
Sbjct: 586 ECDGKEDCSDGSDEKDCD-CG 605
>AF118224-1|AAD42765.2| 855|Homo sapiens matriptase protein.
Length = 855
Score = 44.4 bits (100), Expect = 0.002
Identities = 30/87 (34%), Positives = 38/87 (43%), Gaps = 24/87 (27%)
Query: 1094 SRQCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEG 1153
S+QC+G+ DC DG DEA C V C T +RC G
Sbjct: 541 SQQCNGKDDCGDGSDEASCPKVNV-VTCTKHT----------------------YRCLNG 577
Query: 1154 LCIA-ARFVCDGRPQCADGSDEAPAAC 1179
LC++ CDG+ C+DGSDE C
Sbjct: 578 LCLSKGNPECDGKEDCSDGSDEKDCDC 604
Score = 42.3 bits (95), Expect = 0.010
Identities = 25/88 (28%), Positives = 31/88 (35%), Gaps = 8/88 (9%)
Query: 1096 QCDGQQDCEDGRDEAECGA-CGGDVRCADG-------TXXXXXXXXXXXXXXXXXXXXDA 1147
+CDG DC D DE C G C +
Sbjct: 470 RCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQT 529
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEA 1175
FRC G C++ C+G+ C DGSDEA
Sbjct: 530 FRCSNGKCLSKSQQCNGKDDCGDGSDEA 557
Score = 38.3 bits (85), Expect = 0.16
Identities = 16/36 (44%), Positives = 17/36 (47%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAACAYGH 1183
F C G CI CDG C D SDE +C GH
Sbjct: 457 FTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGH 492
Score = 34.7 bits (76), Expect = 2.0
Identities = 12/21 (57%), Positives = 16/21 (76%), Gaps = 1/21 (4%)
Query: 1096 QCDGQQDCEDGRDEAECGACG 1116
+CDG++DC DG DE +C CG
Sbjct: 586 ECDGKEDCSDGSDEKDCD-CG 605
>AF057145-1|AAG15395.1| 855|Homo sapiens serine protease TADG15
protein.
Length = 855
Score = 44.4 bits (100), Expect = 0.002
Identities = 30/87 (34%), Positives = 38/87 (43%), Gaps = 24/87 (27%)
Query: 1094 SRQCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEG 1153
S+QC+G+ DC DG DEA C V C T +RC G
Sbjct: 541 SQQCNGKDDCGDGSDEASCPKVNV-VTCTKHT----------------------YRCLNG 577
Query: 1154 LCIA-ARFVCDGRPQCADGSDEAPAAC 1179
LC++ CDG+ C+DGSDE C
Sbjct: 578 LCLSKGNPECDGKEDCSDGSDEKDCDC 604
Score = 42.3 bits (95), Expect = 0.010
Identities = 25/88 (28%), Positives = 31/88 (35%), Gaps = 8/88 (9%)
Query: 1096 QCDGQQDCEDGRDEAECGA-CGGDVRCADG-------TXXXXXXXXXXXXXXXXXXXXDA 1147
+CDG DC D DE C G C +
Sbjct: 470 RCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQT 529
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEA 1175
FRC G C++ C+G+ C DGSDEA
Sbjct: 530 FRCSNGKCLSKSQQCNGKDDCGDGSDEA 557
Score = 38.3 bits (85), Expect = 0.16
Identities = 16/36 (44%), Positives = 17/36 (47%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAACAYGH 1183
F C G CI CDG C D SDE +C GH
Sbjct: 457 FTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGH 492
Score = 34.7 bits (76), Expect = 2.0
Identities = 12/21 (57%), Positives = 16/21 (76%), Gaps = 1/21 (4%)
Query: 1096 QCDGQQDCEDGRDEAECGACG 1116
+CDG++DC DG DE +C CG
Sbjct: 586 ECDGKEDCSDGSDEKDCD-CG 605
>AB030036-1|BAB20376.1| 855|Homo sapiens prostamin protein.
Length = 855
Score = 44.4 bits (100), Expect = 0.002
Identities = 30/87 (34%), Positives = 38/87 (43%), Gaps = 24/87 (27%)
Query: 1094 SRQCDGQQDCEDGRDEAECGACGGDVRCADGTXXXXXXXXXXXXXXXXXXXXDAFRCDEG 1153
S+QC+G+ DC DG DEA C V C T +RC G
Sbjct: 541 SQQCNGKDDCGDGSDEASCPKVNV-VTCTKHT----------------------YRCLNG 577
Query: 1154 LCIA-ARFVCDGRPQCADGSDEAPAAC 1179
LC++ CDG+ C+DGSDE C
Sbjct: 578 LCLSKGNPECDGKEDCSDGSDEKDCDC 604
Score = 42.3 bits (95), Expect = 0.010
Identities = 25/88 (28%), Positives = 31/88 (35%), Gaps = 8/88 (9%)
Query: 1096 QCDGQQDCEDGRDEAECGA-CGGDVRCADG-------TXXXXXXXXXXXXXXXXXXXXDA 1147
+CDG DC D DE C G C +
Sbjct: 470 RCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQT 529
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEA 1175
FRC G C++ C+G+ C DGSDEA
Sbjct: 530 FRCSNGKCLSKSQQCNGKDDCGDGSDEA 557
Score = 38.3 bits (85), Expect = 0.16
Identities = 16/36 (44%), Positives = 17/36 (47%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAACAYGH 1183
F C G CI CDG C D SDE +C GH
Sbjct: 457 FTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGH 492
Score = 34.7 bits (76), Expect = 2.0
Identities = 12/21 (57%), Positives = 16/21 (76%), Gaps = 1/21 (4%)
Query: 1096 QCDGQQDCEDGRDEAECGACG 1116
+CDG++DC DG DE +C CG
Sbjct: 586 ECDGKEDCSDGSDEKDCD-CG 605
>X05495-1|CAA29045.1| 575|Homo sapiens thrombomodulin protein.
Length = 575
Score = 44.0 bits (99), Expect = 0.003
Identities = 19/43 (44%), Positives = 24/43 (55%), Gaps = 1/43 (2%)
Query: 561 APLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
AP W+ C+ +NGGC H C P C CP G L AD ++C
Sbjct: 239 APGAWD-CSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSC 280
Score = 41.5 bits (93), Expect = 0.018
Identities = 19/45 (42%), Positives = 23/45 (51%), Gaps = 4/45 (8%)
Query: 863 GSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS 907
G+ C V+NGGC H C PG RC CPA L D +C+
Sbjct: 241 GAWDCSVENGGCEHACNAIPGAP----RCQCPAGAALQADGRSCT 281
Score = 37.5 bits (83), Expect = 0.29
Identities = 21/68 (30%), Positives = 31/68 (45%), Gaps = 5/68 (7%)
Query: 240 PADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPG-YNCACPTGVKLRENSSTTC 298
PA + + R ++ C N C H C+ +PD PG Y+C C TG +L + C
Sbjct: 268 PAGAALQADGRSCTASATQSC---NDLCEHFCVPNPDQPGSYSCMCETGYRLAADQH-RC 323
Query: 299 YDSPQMLL 306
D +L
Sbjct: 324 EDVDDCIL 331
Score = 37.5 bits (83), Expect = 0.29
Identities = 16/44 (36%), Positives = 21/44 (47%), Gaps = 1/44 (2%)
Query: 871 NGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL 914
N C H C+P P D Y C C YRL D C + ++ +L
Sbjct: 289 NDLCEHFCVPNP-DQPGSYSCMCETGYRLAADQHRCEDVDDCIL 331
Score = 33.5 bits (73), Expect = 4.7
Identities = 14/46 (30%), Positives = 19/46 (41%), Gaps = 2/46 (4%)
Query: 258 YPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQ 303
+ C N GC H C P P C CP G L+ + + + Q
Sbjct: 243 WDCSVENGGCEHACNAIPGAP--RCQCPAGAALQADGRSCTASATQ 286
>M16552-1|AAB59508.1| 575|Homo sapiens THBD protein.
Length = 575
Score = 44.0 bits (99), Expect = 0.003
Identities = 19/43 (44%), Positives = 24/43 (55%), Gaps = 1/43 (2%)
Query: 561 APLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
AP W+ C+ +NGGC H C P C CP G L AD ++C
Sbjct: 239 APGAWD-CSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSC 280
Score = 41.5 bits (93), Expect = 0.018
Identities = 19/45 (42%), Positives = 23/45 (51%), Gaps = 4/45 (8%)
Query: 863 GSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS 907
G+ C V+NGGC H C PG RC CPA L D +C+
Sbjct: 241 GAWDCSVENGGCEHACNAIPGAP----RCQCPAGAALQADGRSCT 281
Score = 37.5 bits (83), Expect = 0.29
Identities = 21/68 (30%), Positives = 31/68 (45%), Gaps = 5/68 (7%)
Query: 240 PADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPG-YNCACPTGVKLRENSSTTC 298
PA + + R ++ C N C H C+ +PD PG Y+C C TG +L + C
Sbjct: 268 PAGAALQADGRSCTASATQSC---NDLCEHFCVPNPDQPGSYSCMCETGYRLAADQH-RC 323
Query: 299 YDSPQMLL 306
D +L
Sbjct: 324 EDVDDCIL 331
Score = 37.5 bits (83), Expect = 0.29
Identities = 16/44 (36%), Positives = 21/44 (47%), Gaps = 1/44 (2%)
Query: 871 NGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL 914
N C H C+P P D Y C C YRL D C + ++ +L
Sbjct: 289 NDLCEHFCVPNP-DQPGSYSCMCETGYRLAADQHRCEDVDDCIL 331
Score = 33.5 bits (73), Expect = 4.7
Identities = 14/46 (30%), Positives = 19/46 (41%), Gaps = 2/46 (4%)
Query: 258 YPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQ 303
+ C N GC H C P P C CP G L+ + + + Q
Sbjct: 243 WDCSVENGGCEHACNAIPGAP--RCQCPAGAALQADGRSCTASATQ 286
>J02973-1|AAA61175.1| 575|Homo sapiens THBD protein.
Length = 575
Score = 44.0 bits (99), Expect = 0.003
Identities = 19/43 (44%), Positives = 24/43 (55%), Gaps = 1/43 (2%)
Query: 561 APLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
AP W+ C+ +NGGC H C P C CP G L AD ++C
Sbjct: 239 APGAWD-CSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSC 280
Score = 41.5 bits (93), Expect = 0.018
Identities = 19/45 (42%), Positives = 23/45 (51%), Gaps = 4/45 (8%)
Query: 863 GSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS 907
G+ C V+NGGC H C PG RC CPA L D +C+
Sbjct: 241 GAWDCSVENGGCEHACNAIPGAP----RCQCPAGAALQADGRSCT 281
Score = 37.5 bits (83), Expect = 0.29
Identities = 21/68 (30%), Positives = 31/68 (45%), Gaps = 5/68 (7%)
Query: 240 PADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPG-YNCACPTGVKLRENSSTTC 298
PA + + R ++ C N C H C+ +PD PG Y+C C TG +L + C
Sbjct: 268 PAGAALQADGRSCTASATQSC---NDLCEHFCVPNPDQPGSYSCMCETGYRLAADQH-RC 323
Query: 299 YDSPQMLL 306
D +L
Sbjct: 324 EDVDDCIL 331
Score = 37.5 bits (83), Expect = 0.29
Identities = 16/44 (36%), Positives = 21/44 (47%), Gaps = 1/44 (2%)
Query: 871 NGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL 914
N C H C+P P D Y C C YRL D C + ++ +L
Sbjct: 289 NDLCEHFCVPNP-DQPGSYSCMCETGYRLAADQHRCEDVDDCIL 331
Score = 33.5 bits (73), Expect = 4.7
Identities = 14/46 (30%), Positives = 19/46 (41%), Gaps = 2/46 (4%)
Query: 258 YPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQ 303
+ C N GC H C P P C CP G L+ + + + Q
Sbjct: 243 WDCSVENGGCEHACNAIPGAP--RCQCPAGAALQADGRSCTASATQ 286
>D00210-1|BAA00149.1| 575|Homo sapiens thrombomodulin precursor
protein.
Length = 575
Score = 44.0 bits (99), Expect = 0.003
Identities = 19/43 (44%), Positives = 24/43 (55%), Gaps = 1/43 (2%)
Query: 561 APLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
AP W+ C+ +NGGC H C P C CP G L AD ++C
Sbjct: 239 APGAWD-CSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSC 280
Score = 41.5 bits (93), Expect = 0.018
Identities = 19/45 (42%), Positives = 23/45 (51%), Gaps = 4/45 (8%)
Query: 863 GSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS 907
G+ C V+NGGC H C PG RC CPA L D +C+
Sbjct: 241 GAWDCSVENGGCEHACNAIPGAP----RCQCPAGAALQADGRSCT 281
Score = 37.5 bits (83), Expect = 0.29
Identities = 21/68 (30%), Positives = 31/68 (45%), Gaps = 5/68 (7%)
Query: 240 PADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPG-YNCACPTGVKLRENSSTTC 298
PA + + R ++ C N C H C+ +PD PG Y+C C TG +L + C
Sbjct: 268 PAGAALQADGRSCTASATQSC---NDLCEHFCVPNPDQPGSYSCMCETGYRLAADQH-RC 323
Query: 299 YDSPQMLL 306
D +L
Sbjct: 324 EDVDDCIL 331
Score = 37.5 bits (83), Expect = 0.29
Identities = 16/44 (36%), Positives = 21/44 (47%), Gaps = 1/44 (2%)
Query: 871 NGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL 914
N C H C+P P D Y C C YRL D C + ++ +L
Sbjct: 289 NDLCEHFCVPNP-DQPGSYSCMCETGYRLAADQHRCEDVDDCIL 331
Score = 33.5 bits (73), Expect = 4.7
Identities = 14/46 (30%), Positives = 19/46 (41%), Gaps = 2/46 (4%)
Query: 258 YPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQ 303
+ C N GC H C P P C CP G L+ + + + Q
Sbjct: 243 WDCSVENGGCEHACNAIPGAP--RCQCPAGAALQADGRSCTASATQ 286
>BC131763-1|AAI31764.1| 581|Homo sapiens matrilin 4 protein.
Length = 581
Score = 44.0 bits (99), Expect = 0.003
Identities = 15/36 (41%), Positives = 20/36 (55%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA+ GC H C N P Y C C +G L D+++C
Sbjct: 219 CAEGTHGCEHHCVNSPGSYFCHCQVGFVLQQDQRSC 254
Score = 33.9 bits (74), Expect = 3.5
Identities = 16/62 (25%), Positives = 27/62 (43%), Gaps = 4/62 (6%)
Query: 845 KDLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNI 904
+ D I + L +++ + C GC H C+ +PG Y C C + L +D
Sbjct: 197 ESFDLIQEFGLQFQSRLCAIDLCAEGTHGCEHHCVNSPG----SYFCHCQVGFVLQQDQR 252
Query: 905 TC 906
+C
Sbjct: 253 SC 254
Score = 32.7 bits (71), Expect = 8.1
Identities = 14/36 (38%), Positives = 18/36 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
C + GC C + Y C CP G +L AD K+C
Sbjct: 301 CNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSC 336
>BC111690-1|AAI11691.1| 807|Homo sapiens SCUBE2 protein protein.
Length = 807
Score = 44.0 bits (99), Expect = 0.003
Identities = 16/36 (44%), Positives = 20/36 (55%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
C NGGC H C N + CGC G +L D+K+C
Sbjct: 327 CQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSC 362
Score = 41.9 bits (94), Expect = 0.013
Identities = 17/39 (43%), Positives = 22/39 (56%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
N C+ +NGGC +C N Y C C G +L +KK CV
Sbjct: 405 NECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCV 443
Score = 41.1 bits (92), Expect = 0.023
Identities = 15/37 (40%), Positives = 21/37 (56%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
C ++NGGC H C N Y C C G L+ ++ TC+
Sbjct: 132 CLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCI 168
Score = 41.1 bits (92), Expect = 0.023
Identities = 16/36 (44%), Positives = 19/36 (52%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA +NGGC C + C CP+G L D KTC
Sbjct: 286 CAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTC 321
Score = 39.9 bits (89), Expect = 0.054
Identities = 17/45 (37%), Positives = 22/45 (48%), Gaps = 4/45 (8%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
C V+NGGC C D T C+CP + L D TC + +E
Sbjct: 286 CAVNNGGCDRTCK----DTSTGVHCSCPVGFTLQLDGKTCKDIDE 326
Score = 38.7 bits (86), Expect = 0.12
Identities = 20/50 (40%), Positives = 27/50 (54%), Gaps = 5/50 (10%)
Query: 865 NQCGVD-NGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFL 913
++CG + NGGC H CL PG +YRC C + L D C + +E L
Sbjct: 88 DECGNELNGGCVHDCLNIPG----NYRCTCFDGFMLAHDGHNCLDVDECL 133
Score = 38.7 bits (86), Expect = 0.12
Identities = 15/43 (34%), Positives = 24/43 (55%), Gaps = 4/43 (9%)
Query: 864 SNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
+N+C ++NGGC +C+ T G Y C C Y+L+ + C
Sbjct: 404 TNECSINNGGCQQVCVNTVG----SYECQCHPGYKLHWNKKDC 442
Score = 37.5 bits (83), Expect = 0.29
Identities = 17/44 (38%), Positives = 23/44 (52%), Gaps = 1/44 (2%)
Query: 568 CADD-NGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFL 610
C ++ NGGC H C N P +Y C C G L D C++ + L
Sbjct: 90 CGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECL 133
Score = 36.3 bits (80), Expect = 0.66
Identities = 19/63 (30%), Positives = 28/63 (44%), Gaps = 2/63 (3%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISL 319
C +NN GC H C+ Y C C G L +N T + S + L + + S I
Sbjct: 132 CLENNGGCQHTCVNVMG--SYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICK 189
Query: 320 DSP 322
++P
Sbjct: 190 EAP 192
Score = 36.3 bits (80), Expect = 0.66
Identities = 16/48 (33%), Positives = 23/48 (47%), Gaps = 4/48 (8%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL 914
C NGGC H C D C+C Y+++ D +C E E+ +L
Sbjct: 217 CNHGNGGCQHSC----DDTADGPECSCHPQYKMHTDGRSCLEREDTVL 260
Score = 35.5 bits (78), Expect = 1.2
Identities = 14/40 (35%), Positives = 20/40 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPE 607
C NGGC H C + D C C ++ D ++C+E E
Sbjct: 217 CNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLERE 256
Score = 34.3 bits (75), Expect = 2.7
Identities = 13/38 (34%), Positives = 21/38 (55%), Gaps = 1/38 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYI-CGCPLGLELTADKKTCV 604
C + + GCSH+C P + C C G EL +++ C+
Sbjct: 177 CMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCI 214
Score = 33.9 bits (74), Expect = 3.5
Identities = 15/47 (31%), Positives = 23/47 (48%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
++C +NGGC H C+ +V Y C C + L+ + TC E
Sbjct: 130 DECLENNGGCQHTCV----NVMGSYECCCKEGFFLSDNQHTCIHRSE 172
Score = 33.9 bits (74), Expect = 3.5
Identities = 14/47 (29%), Positives = 22/47 (46%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
++C NGGC H C G + C C ++L D +C + +E
Sbjct: 325 DECQTRNGGCDHFCKNIVG----SFDCGCKKGFKLLTDEKSCQDVDE 367
>BC053357-1|AAH53357.1| 575|Homo sapiens thrombomodulin protein.
Length = 575
Score = 44.0 bits (99), Expect = 0.003
Identities = 19/43 (44%), Positives = 24/43 (55%), Gaps = 1/43 (2%)
Query: 561 APLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
AP W+ C+ +NGGC H C P C CP G L AD ++C
Sbjct: 239 APGAWD-CSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSC 280
Score = 41.5 bits (93), Expect = 0.018
Identities = 19/45 (42%), Positives = 23/45 (51%), Gaps = 4/45 (8%)
Query: 863 GSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS 907
G+ C V+NGGC H C PG RC CPA L D +C+
Sbjct: 241 GAWDCSVENGGCEHACNAIPGAP----RCQCPAGAALQADGRSCT 281
Score = 37.5 bits (83), Expect = 0.29
Identities = 21/68 (30%), Positives = 31/68 (45%), Gaps = 5/68 (7%)
Query: 240 PADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPG-YNCACPTGVKLRENSSTTC 298
PA + + R ++ C N C H C+ +PD PG Y+C C TG +L + C
Sbjct: 268 PAGAALQADGRSCTASATQSC---NDLCEHFCVPNPDQPGSYSCMCETGYRLAADQH-RC 323
Query: 299 YDSPQMLL 306
D +L
Sbjct: 324 EDVDDCIL 331
Score = 37.5 bits (83), Expect = 0.29
Identities = 16/44 (36%), Positives = 21/44 (47%), Gaps = 1/44 (2%)
Query: 871 NGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL 914
N C H C+P P D Y C C YRL D C + ++ +L
Sbjct: 289 NDLCEHFCVPNP-DQPGSYSCMCETGYRLAADQHRCEDVDDCIL 331
Score = 33.5 bits (73), Expect = 4.7
Identities = 14/46 (30%), Positives = 19/46 (41%), Gaps = 2/46 (4%)
Query: 258 YPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQ 303
+ C N GC H C P P C CP G L+ + + + Q
Sbjct: 243 WDCSVENGGCEHACNAIPGAP--RCQCPAGAALQADGRSCTASATQ 286
>BC035602-1|AAH35602.2| 575|Homo sapiens thrombomodulin protein.
Length = 575
Score = 44.0 bits (99), Expect = 0.003
Identities = 19/43 (44%), Positives = 24/43 (55%), Gaps = 1/43 (2%)
Query: 561 APLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
AP W+ C+ +NGGC H C P C CP G L AD ++C
Sbjct: 239 APGAWD-CSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSC 280
Score = 41.5 bits (93), Expect = 0.018
Identities = 19/45 (42%), Positives = 23/45 (51%), Gaps = 4/45 (8%)
Query: 863 GSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS 907
G+ C V+NGGC H C PG RC CPA L D +C+
Sbjct: 241 GAWDCSVENGGCEHACNAIPGAP----RCQCPAGAALQADGRSCT 281
Score = 37.5 bits (83), Expect = 0.29
Identities = 21/68 (30%), Positives = 31/68 (45%), Gaps = 5/68 (7%)
Query: 240 PADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPG-YNCACPTGVKLRENSSTTC 298
PA + + R ++ C N C H C+ +PD PG Y+C C TG +L + C
Sbjct: 268 PAGAALQADGRSCTASATQSC---NDLCEHFCVPNPDQPGSYSCMCETGYRLAADQH-RC 323
Query: 299 YDSPQMLL 306
D +L
Sbjct: 324 EDVDDCIL 331
Score = 37.5 bits (83), Expect = 0.29
Identities = 16/44 (36%), Positives = 21/44 (47%), Gaps = 1/44 (2%)
Query: 871 NGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL 914
N C H C+P P D Y C C YRL D C + ++ +L
Sbjct: 289 NDLCEHFCVPNP-DQPGSYSCMCETGYRLAADQHRCEDVDDCIL 331
Score = 33.5 bits (73), Expect = 4.7
Identities = 14/46 (30%), Positives = 19/46 (41%), Gaps = 2/46 (4%)
Query: 258 YPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQ 303
+ C N GC H C P P C CP G L+ + + + Q
Sbjct: 243 WDCSVENGGCEHACNAIPGAP--RCQCPAGAALQADGRSCTASATQ 286
>AL049651-2|CAB51954.1| 575|Homo sapiens thrombomodulin protein.
Length = 575
Score = 44.0 bits (99), Expect = 0.003
Identities = 19/43 (44%), Positives = 24/43 (55%), Gaps = 1/43 (2%)
Query: 561 APLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
AP W+ C+ +NGGC H C P C CP G L AD ++C
Sbjct: 239 APGAWD-CSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSC 280
Score = 41.5 bits (93), Expect = 0.018
Identities = 19/45 (42%), Positives = 23/45 (51%), Gaps = 4/45 (8%)
Query: 863 GSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS 907
G+ C V+NGGC H C PG RC CPA L D +C+
Sbjct: 241 GAWDCSVENGGCEHACNAIPGAP----RCQCPAGAALQADGRSCT 281
Score = 37.5 bits (83), Expect = 0.29
Identities = 21/68 (30%), Positives = 31/68 (45%), Gaps = 5/68 (7%)
Query: 240 PADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPG-YNCACPTGVKLRENSSTTC 298
PA + + R ++ C N C H C+ +PD PG Y+C C TG +L + C
Sbjct: 268 PAGAALQADGRSCTASATQSC---NDLCEHFCVPNPDQPGSYSCMCETGYRLAADQH-RC 323
Query: 299 YDSPQMLL 306
D +L
Sbjct: 324 EDVDDCIL 331
Score = 37.5 bits (83), Expect = 0.29
Identities = 16/44 (36%), Positives = 21/44 (47%), Gaps = 1/44 (2%)
Query: 871 NGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL 914
N C H C+P P D Y C C YRL D C + ++ +L
Sbjct: 289 NDLCEHFCVPNP-DQPGSYSCMCETGYRLAADQHRCEDVDDCIL 331
Score = 33.5 bits (73), Expect = 4.7
Identities = 14/46 (30%), Positives = 19/46 (41%), Gaps = 2/46 (4%)
Query: 258 YPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQ 303
+ C N GC H C P P C CP G L+ + + + Q
Sbjct: 243 WDCSVENGGCEHACNAIPGAP--RCQCPAGAALQADGRSCTASATQ 286
>AL021578-3|CAB39280.1| 581|Homo sapiens matrilin 4 protein.
Length = 581
Score = 44.0 bits (99), Expect = 0.003
Identities = 15/36 (41%), Positives = 20/36 (55%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA+ GC H C N P Y C C +G L D+++C
Sbjct: 219 CAEGTHGCEHHCVNSPGSYFCHCQVGFVLQQDQRSC 254
Score = 33.9 bits (74), Expect = 3.5
Identities = 16/62 (25%), Positives = 27/62 (43%), Gaps = 4/62 (6%)
Query: 845 KDLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNI 904
+ D I + L +++ + C GC H C+ +PG Y C C + L +D
Sbjct: 197 ESFDLIQEFGLQFQSRLCAIDLCAEGTHGCEHHCVNSPG----SYFCHCQVGFVLQQDQR 252
Query: 905 TC 906
+C
Sbjct: 253 SC 254
Score = 32.7 bits (71), Expect = 8.1
Identities = 14/36 (38%), Positives = 18/36 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
C + GC C + Y C CP G +L AD K+C
Sbjct: 301 CNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSC 336
>AL021578-2|CAI21077.1| 432|Homo sapiens matrilin 4 protein.
Length = 432
Score = 44.0 bits (99), Expect = 0.003
Identities = 15/36 (41%), Positives = 20/36 (55%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA+ GC H C N P Y C C +G L D+++C
Sbjct: 70 CAEGTHGCEHHCVNSPGSYFCHCQVGFVLQQDQRSC 105
Score = 39.1 bits (87), Expect = 0.094
Identities = 16/41 (39%), Positives = 22/41 (53%)
Query: 564 GWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
G + CA+ GC H C N + C C G +L AD K+C+
Sbjct: 25 GKDQCAEGGHGCQHQCVNAWAMFHCTCNPGYKLAADNKSCL 65
Score = 32.7 bits (71), Expect = 8.1
Identities = 14/36 (38%), Positives = 18/36 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
C + GC C + Y C CP G +L AD K+C
Sbjct: 152 CNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSC 187
>AL021578-1|CAB46380.1| 622|Homo sapiens matrilin 4 protein.
Length = 622
Score = 44.0 bits (99), Expect = 0.003
Identities = 15/36 (41%), Positives = 20/36 (55%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA+ GC H C N P Y C C +G L D+++C
Sbjct: 260 CAEGTHGCEHHCVNSPGSYFCHCQVGFVLQQDQRSC 295
Score = 39.1 bits (87), Expect = 0.094
Identities = 16/41 (39%), Positives = 22/41 (53%)
Query: 564 GWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
G + CA+ GC H C N + C C G +L AD K+C+
Sbjct: 215 GKDQCAEGGHGCQHQCVNAWAMFHCTCNPGYKLAADNKSCL 255
Score = 37.5 bits (83), Expect = 0.29
Identities = 17/62 (27%), Positives = 28/62 (45%), Gaps = 4/62 (6%)
Query: 845 KDLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNI 904
+ D I + L +++ G +QC GC H C+ + + C C Y+L DN
Sbjct: 197 ESFDLIQEFGLQFQSRLCGKDQCAEGGHGCQHQCV----NAWAMFHCTCNPGYKLAADNK 252
Query: 905 TC 906
+C
Sbjct: 253 SC 254
Score = 32.7 bits (71), Expect = 8.1
Identities = 14/36 (38%), Positives = 18/36 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
C + GC C + Y C CP G +L AD K+C
Sbjct: 342 CNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSC 377
>AK131552-1|BAD18686.1| 682|Homo sapiens protein ( Homo sapiens
cDNA FLJ16792 fis, clone TBAES2007379, moderately
similar to Homo sapiens signal peptide, CUB domain,
EGF-like 2 (SCUBE2). ).
Length = 682
Score = 44.0 bits (99), Expect = 0.003
Identities = 16/36 (44%), Positives = 20/36 (55%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
C NGGC H C N + CGC G +L D+K+C
Sbjct: 327 CQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSC 362
Score = 41.9 bits (94), Expect = 0.013
Identities = 17/39 (43%), Positives = 22/39 (56%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
N C+ +NGGC +C N Y C C G +L +KK CV
Sbjct: 405 NECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCV 443
Score = 41.1 bits (92), Expect = 0.023
Identities = 15/37 (40%), Positives = 21/37 (56%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
C ++NGGC H C N Y C C G L+ ++ TC+
Sbjct: 132 CLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCI 168
Score = 41.1 bits (92), Expect = 0.023
Identities = 16/36 (44%), Positives = 19/36 (52%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA +NGGC C + C CP+G L D KTC
Sbjct: 286 CAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTC 321
Score = 39.9 bits (89), Expect = 0.054
Identities = 17/45 (37%), Positives = 22/45 (48%), Gaps = 4/45 (8%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
C V+NGGC C D T C+CP + L D TC + +E
Sbjct: 286 CAVNNGGCDRTCK----DTSTGVHCSCPVGFTLQLDGKTCKDIDE 326
Score = 38.7 bits (86), Expect = 0.12
Identities = 20/50 (40%), Positives = 27/50 (54%), Gaps = 5/50 (10%)
Query: 865 NQCGVD-NGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFL 913
++CG + NGGC H CL PG +YRC C + L D C + +E L
Sbjct: 88 DECGNELNGGCVHDCLNIPG----NYRCTCFDGFMLAHDGHNCLDVDECL 133
Score = 38.7 bits (86), Expect = 0.12
Identities = 15/43 (34%), Positives = 24/43 (55%), Gaps = 4/43 (9%)
Query: 864 SNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
+N+C ++NGGC +C+ T G Y C C Y+L+ + C
Sbjct: 404 TNECSINNGGCQQVCVNTVG----SYECQCHPGYKLHWNKKDC 442
Score = 37.5 bits (83), Expect = 0.29
Identities = 17/44 (38%), Positives = 23/44 (52%), Gaps = 1/44 (2%)
Query: 568 CADD-NGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFL 610
C ++ NGGC H C N P +Y C C G L D C++ + L
Sbjct: 90 CGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECL 133
Score = 36.3 bits (80), Expect = 0.66
Identities = 19/63 (30%), Positives = 28/63 (44%), Gaps = 2/63 (3%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQMLLVVAQRSTISKISL 319
C +NN GC H C+ Y C C G L +N T + S + L + + S I
Sbjct: 132 CLENNGGCQHTCVNVMG--SYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICK 189
Query: 320 DSP 322
++P
Sbjct: 190 EAP 192
Score = 36.3 bits (80), Expect = 0.66
Identities = 16/48 (33%), Positives = 23/48 (47%), Gaps = 4/48 (8%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL 914
C NGGC H C D C+C Y+++ D +C E E+ +L
Sbjct: 217 CNHGNGGCQHSC----DDTADGPECSCHPQYKMHTDGRSCLEREDTVL 260
Score = 35.5 bits (78), Expect = 1.2
Identities = 14/40 (35%), Positives = 20/40 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPE 607
C NGGC H C + D C C ++ D ++C+E E
Sbjct: 217 CNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLERE 256
Score = 34.3 bits (75), Expect = 2.7
Identities = 13/38 (34%), Positives = 21/38 (55%), Gaps = 1/38 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYI-CGCPLGLELTADKKTCV 604
C + + GCSH+C P + C C G EL +++ C+
Sbjct: 177 CMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCI 214
Score = 33.9 bits (74), Expect = 3.5
Identities = 15/47 (31%), Positives = 23/47 (48%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
++C +NGGC H C+ +V Y C C + L+ + TC E
Sbjct: 130 DECLENNGGCQHTCV----NVMGSYECCCKEGFFLSDNQHTCIHRSE 172
Score = 33.9 bits (74), Expect = 3.5
Identities = 14/47 (29%), Positives = 22/47 (46%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
++C NGGC H C G + C C ++L D +C + +E
Sbjct: 325 DECQTRNGGCDHFCKNIVG----SFDCGCKKGFKLLTDEKSCQDVDE 367
>AJ007581-1|CAA07569.1| 581|Homo sapiens matrilin-4 protein.
Length = 581
Score = 44.0 bits (99), Expect = 0.003
Identities = 15/36 (41%), Positives = 20/36 (55%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA+ GC H C N P Y C C +G L D+++C
Sbjct: 219 CAEGTHGCEHHCVNSPGSYFCHCQVGFVLQQDQRSC 254
Score = 33.9 bits (74), Expect = 3.5
Identities = 16/62 (25%), Positives = 27/62 (43%), Gaps = 4/62 (6%)
Query: 845 KDLDYISDLKLYHRAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNI 904
+ D I + L +++ + C GC H C+ +PG Y C C + L +D
Sbjct: 197 ESFDLIQEFGLQFQSRLCAIDLCAEGTHGCEHHCVNSPG----SYFCHCQVGFVLQQDQR 252
Query: 905 TC 906
+C
Sbjct: 253 SC 254
Score = 32.7 bits (71), Expect = 8.1
Identities = 14/36 (38%), Positives = 18/36 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
C + GC C + Y C CP G +L AD K+C
Sbjct: 301 CNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSC 336
>AF495471-1|AAM03232.1| 575|Homo sapiens thrombomodulin protein.
Length = 575
Score = 44.0 bits (99), Expect = 0.003
Identities = 19/43 (44%), Positives = 24/43 (55%), Gaps = 1/43 (2%)
Query: 561 APLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
AP W+ C+ +NGGC H C P C CP G L AD ++C
Sbjct: 239 APGAWD-CSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSC 280
Score = 41.5 bits (93), Expect = 0.018
Identities = 19/45 (42%), Positives = 23/45 (51%), Gaps = 4/45 (8%)
Query: 863 GSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS 907
G+ C V+NGGC H C PG RC CPA L D +C+
Sbjct: 241 GAWDCSVENGGCEHACNAIPGAP----RCQCPAGAALQADGRSCT 281
Score = 37.5 bits (83), Expect = 0.29
Identities = 21/68 (30%), Positives = 31/68 (45%), Gaps = 5/68 (7%)
Query: 240 PADIKVYDESRQIISAEDYPCKKNNAGCSHLCLLSPDPPG-YNCACPTGVKLRENSSTTC 298
PA + + R ++ C N C H C+ +PD PG Y+C C TG +L + C
Sbjct: 268 PAGAALQADGRSCTASATQSC---NDLCEHFCVPNPDQPGSYSCMCETGYRLAADQH-RC 323
Query: 299 YDSPQMLL 306
D +L
Sbjct: 324 EDVDDCIL 331
Score = 37.5 bits (83), Expect = 0.29
Identities = 16/44 (36%), Positives = 21/44 (47%), Gaps = 1/44 (2%)
Query: 871 NGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL 914
N C H C+P P D Y C C YRL D C + ++ +L
Sbjct: 289 NDLCEHFCVPNP-DQPGSYSCMCETGYRLAADQHRCEDVDDCIL 331
Score = 33.5 bits (73), Expect = 4.7
Identities = 14/46 (30%), Positives = 19/46 (41%), Gaps = 2/46 (4%)
Query: 258 YPCKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDSPQ 303
+ C N GC H C P P C CP G L+ + + + Q
Sbjct: 243 WDCSVENGGCEHACNAIPGAP--RCQCPAGAALQADGRSCTASATQ 286
>X12892-1|CAA31383.1| 650|Homo sapiens protein ( H.sapiens mRNA for
protein S. ).
Length = 650
Score = 43.6 bits (98), Expect = 0.004
Identities = 23/67 (34%), Positives = 32/67 (47%), Gaps = 5/67 (7%)
Query: 566 NPCADD---NGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGRLS 622
N C D NGGCS +C N P Y C C G + ++KK C + + + + +I G
Sbjct: 133 NECKDPSNINGGCSQICDNTPGSYHCSCKNGFVMLSNKKDCKDVDECSL--KPSICGTAV 190
Query: 623 IKNEYND 629
KN D
Sbjct: 191 CKNILGD 197
>M14338-1|AAA60181.1| 650|Homo sapiens protein S precursor protein.
Length = 650
Score = 43.6 bits (98), Expect = 0.004
Identities = 23/67 (34%), Positives = 32/67 (47%), Gaps = 5/67 (7%)
Query: 566 NPCADD---NGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAFLVYSRKNIIGRLS 622
N C D NGGCS +C N P Y C C G + ++KK C + + + + +I G
Sbjct: 133 NECKDPSNINGGCSQICDNTPGSYHCSCKNGFVMLSNKKDCKDVDECSL--KPSICGTAV 190
Query: 623 IKNEYND 629
KN D
Sbjct: 191 CKNILGD 197
>CR456446-1|CAG30332.1| 824|Homo sapiens dJ1170K4.2 protein.
Length = 824
Score = 43.6 bits (98), Expect = 0.004
Identities = 29/95 (30%), Positives = 35/95 (36%), Gaps = 12/95 (12%)
Query: 1097 CDGQQDCEDGRDEAECGA-----CGGDVRC------ADGTXXXXXXXXXXXXXXXXXXXX 1145
CDG +DC +G DE C C D C DG
Sbjct: 465 CDGVKDCPNGLDERNCVCRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGT 524
Query: 1146 DAFRCDEGLCIAA-RFVCDGRPQCADGSDEAPAAC 1179
F+C++ C+ CDGRP C DGSDE C
Sbjct: 525 FTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCDC 559
Score = 33.9 bits (74), Expect = 3.5
Identities = 13/21 (61%), Positives = 14/21 (66%), Gaps = 1/21 (4%)
Query: 1096 QCDGQQDCEDGRDEAECGACG 1116
QCDG+ DC DG DE C CG
Sbjct: 541 QCDGRPDCRDGSDEEHCD-CG 560
>AY358398-1|AAQ88764.1| 802|Homo sapiens PVAE354 protein.
Length = 802
Score = 43.6 bits (98), Expect = 0.004
Identities = 29/95 (30%), Positives = 35/95 (36%), Gaps = 12/95 (12%)
Query: 1097 CDGQQDCEDGRDEAECGA-----CGGDVRC------ADGTXXXXXXXXXXXXXXXXXXXX 1145
CDG +DC +G DE C C D C DG
Sbjct: 465 CDGVKDCPNGLDERNCVCRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGT 524
Query: 1146 DAFRCDEGLCIAA-RFVCDGRPQCADGSDEAPAAC 1179
F+C++ C+ CDGRP C DGSDE C
Sbjct: 525 FTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCDC 559
Score = 33.9 bits (74), Expect = 3.5
Identities = 13/21 (61%), Positives = 14/21 (66%), Gaps = 1/21 (4%)
Query: 1096 QCDGQQDCEDGRDEAECGACG 1116
QCDG+ DC DG DE C CG
Sbjct: 541 QCDGRPDCRDGSDEEHCD-CG 560
>AY055384-1|AAL16414.1| 811|Homo sapiens type II transmembrane serine
protease 6 protein.
Length = 811
Score = 43.6 bits (98), Expect = 0.004
Identities = 29/95 (30%), Positives = 35/95 (36%), Gaps = 12/95 (12%)
Query: 1097 CDGQQDCEDGRDEAECGA-----CGGDVRC------ADGTXXXXXXXXXXXXXXXXXXXX 1145
CDG +DC +G DE C C D C DG
Sbjct: 474 CDGVKDCPNGLDERNCVCRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGT 533
Query: 1146 DAFRCDEGLCIAA-RFVCDGRPQCADGSDEAPAAC 1179
F+C++ C+ CDGRP C DGSDE C
Sbjct: 534 FTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCDC 568
Score = 33.9 bits (74), Expect = 3.5
Identities = 13/21 (61%), Positives = 14/21 (66%), Gaps = 1/21 (4%)
Query: 1096 QCDGQQDCEDGRDEAECGACG 1116
QCDG+ DC DG DE C CG
Sbjct: 550 QCDGRPDCRDGSDEEHCD-CG 569
>AY055383-1|AAL16413.1| 811|Homo sapiens type II transmembrane serine
protease 6 protein.
Length = 811
Score = 43.6 bits (98), Expect = 0.004
Identities = 29/95 (30%), Positives = 35/95 (36%), Gaps = 12/95 (12%)
Query: 1097 CDGQQDCEDGRDEAECGA-----CGGDVRC------ADGTXXXXXXXXXXXXXXXXXXXX 1145
CDG +DC +G DE C C D C DG
Sbjct: 474 CDGVKDCPNGLDERNCVCRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGT 533
Query: 1146 DAFRCDEGLCIAA-RFVCDGRPQCADGSDEAPAAC 1179
F+C++ C+ CDGRP C DGSDE C
Sbjct: 534 FTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCDC 568
Score = 33.9 bits (74), Expect = 3.5
Identities = 13/21 (61%), Positives = 14/21 (66%), Gaps = 1/21 (4%)
Query: 1096 QCDGQQDCEDGRDEAECGACG 1116
QCDG+ DC DG DE C CG
Sbjct: 550 QCDGRPDCRDGSDEEHCD-CG 569
>AL022314-2|CAI19335.1| 788|Homo sapiens protein ( Human DNA sequence
from clone RP5-1170K4 on chromosome 22q12.2-13.1.1. ).
Length = 788
Score = 43.6 bits (98), Expect = 0.004
Identities = 29/95 (30%), Positives = 35/95 (36%), Gaps = 12/95 (12%)
Query: 1097 CDGQQDCEDGRDEAECGA-----CGGDVRC------ADGTXXXXXXXXXXXXXXXXXXXX 1145
CDG +DC +G DE C C D C DG
Sbjct: 451 CDGVKDCPNGLDERNCVCRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGT 510
Query: 1146 DAFRCDEGLCIAA-RFVCDGRPQCADGSDEAPAAC 1179
F+C++ C+ CDGRP C DGSDE C
Sbjct: 511 FTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCDC 545
Score = 33.9 bits (74), Expect = 3.5
Identities = 13/21 (61%), Positives = 14/21 (66%), Gaps = 1/21 (4%)
Query: 1096 QCDGQQDCEDGRDEAECGACG 1116
QCDG+ DC DG DE C CG
Sbjct: 527 QCDGRPDCRDGSDEEHCD-CG 546
>AK055132-1|BAB70859.1| 579|Homo sapiens protein ( Homo sapiens cDNA
FLJ30570 fis, clone BRAWH2005998, weakly similar to BONE
MORPHOGENETIC PROTEIN 1 PRECURSOR (EC 3.4.24.-). ).
Length = 579
Score = 43.6 bits (98), Expect = 0.004
Identities = 17/36 (47%), Positives = 22/36 (61%)
Query: 1146 DAFRCDEGLCIAARFVCDGRPQCADGSDEAPAACAY 1181
D FRCD+ +C+ VCDG CADGSDE + +
Sbjct: 263 DEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKF 298
Score = 33.5 bits (73), Expect = 4.7
Identities = 15/33 (45%), Positives = 18/33 (54%), Gaps = 4/33 (12%)
Query: 1097 CDGQQDCEDGRDEAECGA----CGGDVRCADGT 1125
CDG +C DG DE C A CGG++ GT
Sbjct: 279 CDGFANCADGSDETNCSAKFSGCGGNLTGLQGT 311
>AJ862823-1|CAH93521.1| 578|Homo sapiens membrane frizzled related
protein protein.
Length = 578
Score = 43.6 bits (98), Expect = 0.004
Identities = 17/36 (47%), Positives = 22/36 (61%)
Query: 1146 DAFRCDEGLCIAARFVCDGRPQCADGSDEAPAACAY 1181
D FRCD+ +C+ VCDG CADGSDE + +
Sbjct: 262 DEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKF 297
Score = 33.5 bits (73), Expect = 4.7
Identities = 15/33 (45%), Positives = 18/33 (54%), Gaps = 4/33 (12%)
Query: 1097 CDGQQDCEDGRDEAECGA----CGGDVRCADGT 1125
CDG +C DG DE C A CGG++ GT
Sbjct: 278 CDGFANCADGSDETNCSAKFSGCGGNLTGLQGT 310
>AJ319876-1|CAC85953.1| 802|Homo sapiens matriptase-2 protein.
Length = 802
Score = 43.6 bits (98), Expect = 0.004
Identities = 29/95 (30%), Positives = 35/95 (36%), Gaps = 12/95 (12%)
Query: 1097 CDGQQDCEDGRDEAECGA-----CGGDVRC------ADGTXXXXXXXXXXXXXXXXXXXX 1145
CDG +DC +G DE C C D C DG
Sbjct: 465 CDGVKDCPNGLDERNCVCRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGT 524
Query: 1146 DAFRCDEGLCIAA-RFVCDGRPQCADGSDEAPAAC 1179
F+C++ C+ CDGRP C DGSDE C
Sbjct: 525 FTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCDC 559
Score = 33.9 bits (74), Expect = 3.5
Identities = 13/21 (61%), Positives = 14/21 (66%), Gaps = 1/21 (4%)
Query: 1096 QCDGQQDCEDGRDEAECGACG 1116
QCDG+ DC DG DE C CG
Sbjct: 541 QCDGRPDCRDGSDEEHCD-CG 560
>AB055505-1|BAB39771.1| 579|Homo sapiens membrane-type
frizzled-related protein MFRP protein.
Length = 579
Score = 43.6 bits (98), Expect = 0.004
Identities = 17/36 (47%), Positives = 22/36 (61%)
Query: 1146 DAFRCDEGLCIAARFVCDGRPQCADGSDEAPAACAY 1181
D FRCD+ +C+ VCDG CADGSDE + +
Sbjct: 263 DEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKF 298
Score = 33.5 bits (73), Expect = 4.7
Identities = 15/33 (45%), Positives = 18/33 (54%), Gaps = 4/33 (12%)
Query: 1097 CDGQQDCEDGRDEAECGA----CGGDVRCADGT 1125
CDG +C DG DE C A CGG++ GT
Sbjct: 279 CDGFANCADGSDETNCSAKFSGCGGNLTGLQGT 311
>BC042754-1|AAH42754.2| 345|Homo sapiens low density lipoprotein
receptor class A domain containing 3 protein.
Length = 345
Score = 43.2 bits (97), Expect = 0.006
Identities = 30/97 (30%), Positives = 33/97 (34%), Gaps = 18/97 (18%)
Query: 1096 QCDGQQDCEDGRDEAEC----GACG--------------GDVRCADGTXXXXXXXXXXXX 1137
QCDG DC D DE EC CG G RC
Sbjct: 48 QCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCT 107
Query: 1138 XXXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
+ C GLCI F+CDG+ C D SDE
Sbjct: 108 ANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDE 144
Score = 36.3 bits (80), Expect = 0.66
Identities = 14/27 (51%), Positives = 15/27 (55%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDE 1174
F C G CI + CDG P C D SDE
Sbjct: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDE 61
>AK075546-1|BAC11689.1| 345|Homo sapiens protein ( Homo sapiens cDNA
PSEC0246 fis, clone NT2RP3001359, weakly similar to
LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2
PRECURSOR. ).
Length = 345
Score = 43.2 bits (97), Expect = 0.006
Identities = 30/97 (30%), Positives = 33/97 (34%), Gaps = 18/97 (18%)
Query: 1096 QCDGQQDCEDGRDEAEC----GACG--------------GDVRCADGTXXXXXXXXXXXX 1137
QCDG DC D DE EC CG G RC
Sbjct: 48 QCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCT 107
Query: 1138 XXXXXXXXDAFRCDEGLCIAARFVCDGRPQCADGSDE 1174
+ C GLCI F+CDG+ C D SDE
Sbjct: 108 ANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDE 144
Score = 36.3 bits (80), Expect = 0.66
Identities = 14/27 (51%), Positives = 15/27 (55%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDE 1174
F C G CI + CDG P C D SDE
Sbjct: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDE 61
>Y00692-1|CAA68687.1| 676|Homo sapiens preproprotein S protein.
Length = 676
Score = 42.7 bits (96), Expect = 0.008
Identities = 18/41 (43%), Positives = 22/41 (53%), Gaps = 3/41 (7%)
Query: 566 NPCADD---NGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
N C D NGGCS +C N P Y C C G + ++KK C
Sbjct: 159 NECKDPSNINGGCSQICDNTPGSYHCSCKNGFVMLSNKKDC 199
>X62515-1|CAA44373.1| 4393|Homo sapiens Human basement membrane
heparan sulfate proteoglycan core protein protein.
Length = 4393
Score = 42.7 bits (96), Expect = 0.008
Identities = 33/101 (32%), Positives = 36/101 (35%), Gaps = 27/101 (26%)
Query: 1097 CDGQQDCEDGRDEAECG----------------------ACGGDVRCADGTXXXXXXXXX 1134
CDGQ+DCEDG DE +CG C GD C D T
Sbjct: 304 CDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKR 363
Query: 1135 XXXXXXXXXXXDAFRC-DEGLCIAARFVCDGRPQCADGSDE 1174
FRC +CI A F CD C D SDE
Sbjct: 364 PEEVCGPT----QFRCVSTNMCIPASFHCDEESDCPDRSDE 400
Score = 35.9 bits (79), Expect = 0.87
Identities = 13/25 (52%), Positives = 16/25 (64%)
Query: 1150 CDEGLCIAARFVCDGRPQCADGSDE 1174
C G CI ++CDG+ C DGSDE
Sbjct: 292 CRNGHCIPRDYLCDGQEDCEDGSDE 316
>M85289-1|AAA52700.1| 4391|Homo sapiens heparan sulfate proteoglycan
protein.
Length = 4391
Score = 42.7 bits (96), Expect = 0.008
Identities = 33/101 (32%), Positives = 36/101 (35%), Gaps = 27/101 (26%)
Query: 1097 CDGQQDCEDGRDEAECG----------------------ACGGDVRCADGTXXXXXXXXX 1134
CDGQ+DCEDG DE +CG C GD C D T
Sbjct: 304 CDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKR 363
Query: 1135 XXXXXXXXXXXDAFRC-DEGLCIAARFVCDGRPQCADGSDE 1174
FRC +CI A F CD C D SDE
Sbjct: 364 PEEVCGPT----QFRCVSTNMCIPASFHCDEESDCPDRSDE 400
Score = 35.9 bits (79), Expect = 0.87
Identities = 13/25 (52%), Positives = 16/25 (64%)
Query: 1150 CDEGLCIAARFVCDGRPQCADGSDE 1174
C G CI ++CDG+ C DGSDE
Sbjct: 292 CRNGHCIPRDYLCDGQEDCEDGSDE 316
>M57853-1|AAA60357.1| 676|Homo sapiens S protein protein.
Length = 676
Score = 42.7 bits (96), Expect = 0.008
Identities = 18/41 (43%), Positives = 22/41 (53%), Gaps = 3/41 (7%)
Query: 566 NPCADD---NGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
N C D NGGCS +C N P Y C C G + ++KK C
Sbjct: 159 NECKDPSNINGGCSQICDNTPGSYHCSCKNGFVMLSNKKDC 199
>M36564-1|AAA60180.1| 650|Homo sapiens PROS1 protein.
Length = 650
Score = 42.7 bits (96), Expect = 0.008
Identities = 18/41 (43%), Positives = 22/41 (53%), Gaps = 3/41 (7%)
Query: 566 NPCADD---NGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
N C D NGGCS +C N P Y C C G + ++KK C
Sbjct: 133 NECKDPSNINGGCSQICDNTPGSYHCSCKNGFVMLSNKKDC 173
>M15036-1|AAA36479.1| 676|Homo sapiens protein ( Human vitamin
K-dependent plasma protein S mRNA, complete cds. ).
Length = 676
Score = 42.7 bits (96), Expect = 0.008
Identities = 18/41 (43%), Positives = 22/41 (53%), Gaps = 3/41 (7%)
Query: 566 NPCADD---NGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
N C D NGGCS +C N P Y C C G + ++KK C
Sbjct: 159 NECKDPSNINGGCSQICDNTPGSYHCSCKNGFVMLSNKKDC 199
>BC015801-1|AAH15801.1| 676|Homo sapiens PROS1 protein protein.
Length = 676
Score = 42.7 bits (96), Expect = 0.008
Identities = 18/41 (43%), Positives = 22/41 (53%), Gaps = 3/41 (7%)
Query: 566 NPCADD---NGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
N C D NGGCS +C N P Y C C G + ++KK C
Sbjct: 159 NECKDPSNINGGCSQICDNTPGSYHCSCKNGFVMLSNKKDC 199
>AY308744-1|AAP45054.1| 497|Homo sapiens protein S (alpha) protein.
Length = 497
Score = 42.7 bits (96), Expect = 0.008
Identities = 18/41 (43%), Positives = 22/41 (53%), Gaps = 3/41 (7%)
Query: 566 NPCADD---NGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
N C D NGGCS +C N P Y C C G + ++KK C
Sbjct: 159 NECKDPSNINGGCSQICDNTPGSYHCSCKNGFVMLSNKKDC 199
>AL590556-2|CAH71870.1| 4391|Homo sapiens heparan sulfate proteoglycan
2 (perlecan) protein.
Length = 4391
Score = 42.7 bits (96), Expect = 0.008
Identities = 33/101 (32%), Positives = 36/101 (35%), Gaps = 27/101 (26%)
Query: 1097 CDGQQDCEDGRDEAECG----------------------ACGGDVRCADGTXXXXXXXXX 1134
CDGQ+DCEDG DE +CG C GD C D T
Sbjct: 304 CDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKR 363
Query: 1135 XXXXXXXXXXXDAFRC-DEGLCIAARFVCDGRPQCADGSDE 1174
FRC +CI A F CD C D SDE
Sbjct: 364 PEEVCGPT----QFRCVSTNMCIPASFHCDEESDCPDRSDE 400
Score = 35.9 bits (79), Expect = 0.87
Identities = 13/25 (52%), Positives = 16/25 (64%)
Query: 1150 CDEGLCIAARFVCDGRPQCADGSDE 1174
C G CI ++CDG+ C DGSDE
Sbjct: 292 CRNGHCIPRDYLCDGQEDCEDGSDE 316
>AL590103-2|CAI12125.1| 4391|Homo sapiens heparan sulfate proteoglycan
2 (perlecan) protein.
Length = 4391
Score = 42.7 bits (96), Expect = 0.008
Identities = 33/101 (32%), Positives = 36/101 (35%), Gaps = 27/101 (26%)
Query: 1097 CDGQQDCEDGRDEAECG----------------------ACGGDVRCADGTXXXXXXXXX 1134
CDGQ+DCEDG DE +CG C GD C D T
Sbjct: 304 CDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKR 363
Query: 1135 XXXXXXXXXXXDAFRC-DEGLCIAARFVCDGRPQCADGSDE 1174
FRC +CI A F CD C D SDE
Sbjct: 364 PEEVCGPT----QFRCVSTNMCIPASFHCDEESDCPDRSDE 400
Score = 35.9 bits (79), Expect = 0.87
Identities = 13/25 (52%), Positives = 16/25 (64%)
Query: 1150 CDEGLCIAARFVCDGRPQCADGSDE 1174
C G CI ++CDG+ C DGSDE
Sbjct: 292 CRNGHCIPRDYLCDGQEDCEDGSDE 316
>AL445795-1|CAC18534.1| 4370|Homo sapiens heparan sulfate proteoglycan
perlecan protein.
Length = 4370
Score = 42.7 bits (96), Expect = 0.008
Identities = 33/101 (32%), Positives = 36/101 (35%), Gaps = 27/101 (26%)
Query: 1097 CDGQQDCEDGRDEAECG----------------------ACGGDVRCADGTXXXXXXXXX 1134
CDGQ+DCEDG DE +CG C GD C D T
Sbjct: 283 CDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKR 342
Query: 1135 XXXXXXXXXXXDAFRC-DEGLCIAARFVCDGRPQCADGSDE 1174
FRC +CI A F CD C D SDE
Sbjct: 343 PEEVCGPT----QFRCVSTNMCIPASFHCDEESDCPDRSDE 379
Score = 35.9 bits (79), Expect = 0.87
Identities = 13/25 (52%), Positives = 16/25 (64%)
Query: 1150 CDEGLCIAARFVCDGRPQCADGSDE 1174
C G CI ++CDG+ C DGSDE
Sbjct: 271 CRNGHCIPRDYLCDGQEDCEDGSDE 295
>Y13341-1|CAA73785.1| 310|Homo sapiens matrilin-3 precursor
protein.
Length = 310
Score = 42.3 bits (95), Expect = 0.010
Identities = 18/47 (38%), Positives = 25/47 (53%), Gaps = 3/47 (6%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
++C + + GC H+C+ D Y C C Y LN+D TCS EE
Sbjct: 216 DKCALGSHGCQHICV---SDGAASYHCDCYPGYTLNEDKKTCSATEE 259
Score = 39.9 bits (89), Expect = 0.054
Identities = 17/50 (34%), Positives = 26/50 (52%), Gaps = 3/50 (6%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL 914
++C ++ GC H+C+ D Y C C Y LN+D TCS ++ L
Sbjct: 132 DRCALNTHGCEHICV---NDRSGSYHCECYEGYTLNEDRKTCSAQDKCAL 178
Score = 39.5 bits (88), Expect = 0.071
Identities = 18/37 (48%), Positives = 20/37 (54%), Gaps = 1/37 (2%)
Query: 568 CADDNGGCSHLCFN-RPDDYICGCPLGLELTADKKTC 603
CA GC H+C N R + C C G L ADKKTC
Sbjct: 176 CALGTHGCQHICVNDRTGSHHCECYEGYTLNADKKTC 212
Score = 39.1 bits (87), Expect = 0.094
Identities = 17/37 (45%), Positives = 20/37 (54%), Gaps = 1/37 (2%)
Query: 568 CADDNGGCSHLCFN-RPDDYICGCPLGLELTADKKTC 603
CA + GC H+C N R Y C C G L D+KTC
Sbjct: 134 CALNTHGCEHICVNDRSGSYHCECYEGYTLNEDRKTC 170
Score = 35.9 bits (79), Expect = 0.87
Identities = 16/50 (32%), Positives = 22/50 (44%), Gaps = 3/50 (6%)
Query: 858 RAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS 907
R ++C + GC H+C+ D + C C Y LN D TCS
Sbjct: 167 RKTCSAQDKCALGTHGCQHICV---NDRTGSHHCECYEGYTLNADKKTCS 213
Score = 35.5 bits (78), Expect = 1.2
Identities = 17/41 (41%), Positives = 20/41 (48%), Gaps = 1/41 (2%)
Query: 568 CADDNGGCSHLCFNR-PDDYICGCPLGLELTADKKTCVEPE 607
CA + GC H+C + Y C C G L DKKTC E
Sbjct: 218 CALGSHGCQHICVSDGAASYHCDCYPGYTLNEDKKTCSATE 258
Score = 34.7 bits (76), Expect = 2.0
Identities = 15/39 (38%), Positives = 20/39 (51%), Gaps = 1/39 (2%)
Query: 566 NPCADDNGGCSHLCFNRPDD-YICGCPLGLELTADKKTC 603
+PC C H+C + + + C C G L ADKKTC
Sbjct: 90 DPCVLGTHQCQHVCISDGEGKHHCECSQGYTLNADKKTC 128
>U89336-6|AAB47494.1| 293|Homo sapiens NG3 protein.
Length = 293
Score = 42.3 bits (95), Expect = 0.010
Identities = 16/31 (51%), Positives = 19/31 (61%)
Query: 575 CSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
CSH CFN + CGCP L L D +TC+E
Sbjct: 155 CSHHCFNTAGSFTCGCPHDLVLGVDGRTCME 185
>BX928748-1|CAH74051.1| 5635|Homo sapiens protein ( Human DNA sequence
from clone RP11-465I11 on chromosome 1. ).
Length = 5635
Score = 42.3 bits (95), Expect = 0.010
Identities = 18/36 (50%), Positives = 20/36 (55%), Gaps = 1/36 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA N CSH C N Y C CP GL + AD +TC
Sbjct: 5111 CAAGNP-CSHSCHNAMGTYYCSCPKGLTIAADGRTC 5145
Score = 40.3 bits (90), Expect = 0.041
Identities = 24/80 (30%), Positives = 34/80 (42%), Gaps = 5/80 (6%)
Query: 553 GVKAFRLGAP-LGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE----PE 607
G ++ +G P + N C C+H C N P + C CP G L D K+C P
Sbjct: 5303 GYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPN 5362
Query: 608 AFLVYSRKNIIGRLSIKNEY 627
YS N+ ++N Y
Sbjct: 5363 YGTQYSSYNLARFSPVRNNY 5382
Score = 34.7 bits (76), Expect = 2.0
Identities = 14/34 (41%), Positives = 18/34 (52%)
Query: 570 DDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
++ C H C N Y C CP G +LT + KTC
Sbjct: 5437 ENTDACQHECKNTFGSYQCICPPGYQLTHNGKTC 5470
>BX284686-12|CAM26220.1| 293|Homo sapiens EGF-like-domain, multiple
8 protein.
Length = 293
Score = 42.3 bits (95), Expect = 0.010
Identities = 16/31 (51%), Positives = 19/31 (61%)
Query: 575 CSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
CSH CFN + CGCP L L D +TC+E
Sbjct: 155 CSHHCFNTAGSFTCGCPHDLVLGVDGRTCME 185
>BC139907-1|AAI39908.1| 486|Homo sapiens matrilin 3 protein.
Length = 486
Score = 42.3 bits (95), Expect = 0.010
Identities = 18/47 (38%), Positives = 25/47 (53%), Gaps = 3/47 (6%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
++C + + GC H+C+ D Y C C Y LN+D TCS EE
Sbjct: 392 DKCALGSHGCQHICV---SDGAASYHCDCYPGYTLNEDKKTCSATEE 435
Score = 39.9 bits (89), Expect = 0.054
Identities = 17/50 (34%), Positives = 26/50 (52%), Gaps = 3/50 (6%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL 914
++C ++ GC H+C+ D Y C C Y LN+D TCS ++ L
Sbjct: 308 DRCALNTHGCEHICV---NDRSGSYHCECYEGYTLNEDRKTCSAQDKCAL 354
Score = 39.5 bits (88), Expect = 0.071
Identities = 18/37 (48%), Positives = 20/37 (54%), Gaps = 1/37 (2%)
Query: 568 CADDNGGCSHLCFN-RPDDYICGCPLGLELTADKKTC 603
CA GC H+C N R + C C G L ADKKTC
Sbjct: 352 CALGTHGCQHICVNDRTGSHHCECYEGYTLNADKKTC 388
Score = 39.1 bits (87), Expect = 0.094
Identities = 17/37 (45%), Positives = 20/37 (54%), Gaps = 1/37 (2%)
Query: 568 CADDNGGCSHLCFN-RPDDYICGCPLGLELTADKKTC 603
CA + GC H+C N R Y C C G L D+KTC
Sbjct: 310 CALNTHGCEHICVNDRSGSYHCECYEGYTLNEDRKTC 346
Score = 35.9 bits (79), Expect = 0.87
Identities = 16/50 (32%), Positives = 22/50 (44%), Gaps = 3/50 (6%)
Query: 858 RAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS 907
R ++C + GC H+C+ D + C C Y LN D TCS
Sbjct: 343 RKTCSAQDKCALGTHGCQHICV---NDRTGSHHCECYEGYTLNADKKTCS 389
Score = 35.5 bits (78), Expect = 1.2
Identities = 17/41 (41%), Positives = 20/41 (48%), Gaps = 1/41 (2%)
Query: 568 CADDNGGCSHLCFNR-PDDYICGCPLGLELTADKKTCVEPE 607
CA + GC H+C + Y C C G L DKKTC E
Sbjct: 394 CALGSHGCQHICVSDGAASYHCDCYPGYTLNEDKKTCSATE 434
Score = 34.7 bits (76), Expect = 2.0
Identities = 15/39 (38%), Positives = 20/39 (51%), Gaps = 1/39 (2%)
Query: 566 NPCADDNGGCSHLCFNRPDD-YICGCPLGLELTADKKTC 603
+PC C H+C + + + C C G L ADKKTC
Sbjct: 266 DPCVLGTHQCQHVCISDGEGKHHCECSQGYTLNADKKTC 304
>BC052591-1|AAH52591.1| 293|Homo sapiens EGF-like-domain, multiple
8 protein.
Length = 293
Score = 42.3 bits (95), Expect = 0.010
Identities = 16/31 (51%), Positives = 19/31 (61%)
Query: 575 CSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
CSH CFN + CGCP L L D +TC+E
Sbjct: 155 CSHHCFNTAGSFTCGCPHDLVLGVDGRTCME 185
>BC035574-1|AAH35574.1| 293|Homo sapiens EGF-like-domain, multiple
8 protein.
Length = 293
Score = 42.3 bits (95), Expect = 0.010
Identities = 16/31 (51%), Positives = 19/31 (61%)
Query: 575 CSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
CSH CFN + CGCP L L D +TC+E
Sbjct: 155 CSHHCFNTAGSFTCGCPHDLVLGVDGRTCME 185
>AY358139-1|AAQ88506.1| 293|Homo sapiens NG3 protein.
Length = 293
Score = 42.3 bits (95), Expect = 0.010
Identities = 16/31 (51%), Positives = 19/31 (61%)
Query: 575 CSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
CSH CFN + CGCP L L D +TC+E
Sbjct: 155 CSHHCFNTAGSFTCGCPHDLVLGVDGRTCME 185
>AY165865-1|AAO18147.1| 2809|Homo sapiens fibrillin-3 short form
precursor transcript variant 3 protein.
Length = 2809
Score = 42.3 bits (95), Expect = 0.010
Identities = 19/47 (40%), Positives = 25/47 (53%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
N+C V NGGC C+ T G YRC+C Y L D C++ +E
Sbjct: 1157 NECRVQNGGCDVHCINTEG----SYRCSCGQGYSLMPDGRACADVDE 1199
Score = 39.1 bits (87), Expect = 0.094
Identities = 16/43 (37%), Positives = 20/43 (46%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEA 608
N CAD + +C N P Y+C CP EL CV+ A
Sbjct: 1447 NECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRA 1489
Score = 38.7 bits (86), Expect = 0.12
Identities = 19/51 (37%), Positives = 24/51 (47%), Gaps = 1/51 (1%)
Query: 559 LGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAF 609
LG + CA G CS+ C N P ++CGCP G A + CV F
Sbjct: 2605 LGGCQDVDECAGRRGPCSYSCANTPGGFLCGCPQGY-FRAGQGHCVSGLGF 2654
Score = 38.3 bits (85), Expect = 0.16
Identities = 15/40 (37%), Positives = 17/40 (42%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
N C NGGC C N Y C C G L D + C +
Sbjct: 1157 NECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACAD 1196
Score = 35.9 bits (79), Expect = 0.87
Identities = 18/54 (33%), Positives = 27/54 (50%), Gaps = 1/54 (1%)
Query: 553 GVKAFRLGAPLGWNPCADDNGGCSHL-CFNRPDDYICGCPLGLELTADKKTCVE 605
G K GA +G N C + CSH C + Y+C C G + +AD+ C++
Sbjct: 1794 GYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMD 1847
Score = 35.1 bits (77), Expect = 1.5
Identities = 14/41 (34%), Positives = 20/41 (48%)
Query: 563 LGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
L + C+ C+ LC N ++C CP G L D +TC
Sbjct: 2404 LDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTC 2444
Score = 33.5 bits (73), Expect = 4.7
Identities = 16/48 (33%), Positives = 26/48 (54%), Gaps = 5/48 (10%)
Query: 865 NQCGVDNGGCSH-LCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
N+C + G C++ +C+ T G +RC CP Y L+ I C + +E
Sbjct: 2086 NECAENPGVCTNGVCVNTDGS----FRCECPFGYSLDFTGINCVDTDE 2129
Score = 33.5 bits (73), Expect = 4.7
Identities = 14/43 (32%), Positives = 22/43 (51%), Gaps = 1/43 (2%)
Query: 566 NPCADDNGGCSH-LCFNRPDDYICGCPLGLELTADKKTCVEPE 607
N CA++ G C++ +C N + C CP G L CV+ +
Sbjct: 2086 NECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTD 2128
Score = 33.1 bits (72), Expect = 6.2
Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 2/36 (5%)
Query: 572 NGGCSHL--CFNRPDDYICGCPLGLELTADKKTCVE 605
+GG HL C N + C C G EL+ D K CV+
Sbjct: 496 SGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVD 531
>AY165864-1|AAO18146.1| 2809|Homo sapiens fibrillin-3 short form
precursor transcript variant 2 protein.
Length = 2809
Score = 42.3 bits (95), Expect = 0.010
Identities = 19/47 (40%), Positives = 25/47 (53%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
N+C V NGGC C+ T G YRC+C Y L D C++ +E
Sbjct: 1157 NECRVQNGGCDVHCINTEG----SYRCSCGQGYSLMPDGRACADVDE 1199
Score = 39.1 bits (87), Expect = 0.094
Identities = 16/43 (37%), Positives = 20/43 (46%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEA 608
N CAD + +C N P Y+C CP EL CV+ A
Sbjct: 1447 NECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRA 1489
Score = 38.7 bits (86), Expect = 0.12
Identities = 19/51 (37%), Positives = 24/51 (47%), Gaps = 1/51 (1%)
Query: 559 LGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAF 609
LG + CA G CS+ C N P ++CGCP G A + CV F
Sbjct: 2605 LGGCQDVDECAGRRGPCSYSCANTPGGFLCGCPQGY-FRAGQGHCVSGLGF 2654
Score = 38.3 bits (85), Expect = 0.16
Identities = 15/40 (37%), Positives = 17/40 (42%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
N C NGGC C N Y C C G L D + C +
Sbjct: 1157 NECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACAD 1196
Score = 35.9 bits (79), Expect = 0.87
Identities = 18/54 (33%), Positives = 27/54 (50%), Gaps = 1/54 (1%)
Query: 553 GVKAFRLGAPLGWNPCADDNGGCSHL-CFNRPDDYICGCPLGLELTADKKTCVE 605
G K GA +G N C + CSH C + Y+C C G + +AD+ C++
Sbjct: 1794 GYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMD 1847
Score = 35.1 bits (77), Expect = 1.5
Identities = 14/41 (34%), Positives = 20/41 (48%)
Query: 563 LGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
L + C+ C+ LC N ++C CP G L D +TC
Sbjct: 2404 LDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTC 2444
Score = 33.5 bits (73), Expect = 4.7
Identities = 16/48 (33%), Positives = 26/48 (54%), Gaps = 5/48 (10%)
Query: 865 NQCGVDNGGCSH-LCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
N+C + G C++ +C+ T G +RC CP Y L+ I C + +E
Sbjct: 2086 NECAENPGVCTNGVCVNTDGS----FRCECPFGYSLDFTGINCVDTDE 2129
Score = 33.5 bits (73), Expect = 4.7
Identities = 14/43 (32%), Positives = 22/43 (51%), Gaps = 1/43 (2%)
Query: 566 NPCADDNGGCSH-LCFNRPDDYICGCPLGLELTADKKTCVEPE 607
N CA++ G C++ +C N + C CP G L CV+ +
Sbjct: 2086 NECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTD 2128
Score = 33.1 bits (72), Expect = 6.2
Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 2/36 (5%)
Query: 572 NGGCSHL--CFNRPDDYICGCPLGLELTADKKTCVE 605
+GG HL C N + C C G EL+ D K CV+
Sbjct: 496 SGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVD 531
>AY165863-1|AAO18145.1| 2809|Homo sapiens fibrillin-3 short form
precursor transcript variant 1 protein.
Length = 2809
Score = 42.3 bits (95), Expect = 0.010
Identities = 19/47 (40%), Positives = 25/47 (53%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
N+C V NGGC C+ T G YRC+C Y L D C++ +E
Sbjct: 1157 NECRVQNGGCDVHCINTEG----SYRCSCGQGYSLMPDGRACADVDE 1199
Score = 39.1 bits (87), Expect = 0.094
Identities = 16/43 (37%), Positives = 20/43 (46%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEA 608
N CAD + +C N P Y+C CP EL CV+ A
Sbjct: 1447 NECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRA 1489
Score = 38.7 bits (86), Expect = 0.12
Identities = 19/51 (37%), Positives = 24/51 (47%), Gaps = 1/51 (1%)
Query: 559 LGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAF 609
LG + CA G CS+ C N P ++CGCP G A + CV F
Sbjct: 2605 LGGCQDVDECAGRRGPCSYSCANTPGGFLCGCPQGY-FRAGQGHCVSGLGF 2654
Score = 38.3 bits (85), Expect = 0.16
Identities = 15/40 (37%), Positives = 17/40 (42%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
N C NGGC C N Y C C G L D + C +
Sbjct: 1157 NECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACAD 1196
Score = 35.9 bits (79), Expect = 0.87
Identities = 18/54 (33%), Positives = 27/54 (50%), Gaps = 1/54 (1%)
Query: 553 GVKAFRLGAPLGWNPCADDNGGCSHL-CFNRPDDYICGCPLGLELTADKKTCVE 605
G K GA +G N C + CSH C + Y+C C G + +AD+ C++
Sbjct: 1794 GYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMD 1847
Score = 35.1 bits (77), Expect = 1.5
Identities = 14/41 (34%), Positives = 20/41 (48%)
Query: 563 LGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
L + C+ C+ LC N ++C CP G L D +TC
Sbjct: 2404 LDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTC 2444
Score = 33.5 bits (73), Expect = 4.7
Identities = 16/48 (33%), Positives = 26/48 (54%), Gaps = 5/48 (10%)
Query: 865 NQCGVDNGGCSH-LCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
N+C + G C++ +C+ T G +RC CP Y L+ I C + +E
Sbjct: 2086 NECAENPGVCTNGVCVNTDGS----FRCECPFGYSLDFTGINCVDTDE 2129
Score = 33.5 bits (73), Expect = 4.7
Identities = 14/43 (32%), Positives = 22/43 (51%), Gaps = 1/43 (2%)
Query: 566 NPCADDNGGCSH-LCFNRPDDYICGCPLGLELTADKKTCVEPE 607
N CA++ G C++ +C N + C CP G L CV+ +
Sbjct: 2086 NECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTD 2128
Score = 33.1 bits (72), Expect = 6.2
Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 2/36 (5%)
Query: 572 NGGCSHL--CFNRPDDYICGCPLGLELTADKKTCVE 605
+GG HL C N + C C G EL+ D K CV+
Sbjct: 496 SGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVD 531
>AL845464-11|CAI41800.2| 293|Homo sapiens EGF-like-domain, multiple
8 protein.
Length = 293
Score = 42.3 bits (95), Expect = 0.010
Identities = 16/31 (51%), Positives = 19/31 (61%)
Query: 575 CSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
CSH CFN + CGCP L L D +TC+E
Sbjct: 155 CSHHCFNTAGSFTCGCPHDLVLGVDGRTCME 185
>AL662884-17|CAI18345.2| 293|Homo sapiens EGF-like-domain, multiple
8 protein.
Length = 293
Score = 42.3 bits (95), Expect = 0.010
Identities = 16/31 (51%), Positives = 19/31 (61%)
Query: 575 CSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
CSH CFN + CGCP L L D +TC+E
Sbjct: 155 CSHHCFNTAGSFTCGCPHDLVLGVDGRTCME 185
>AL662828-17|CAI17428.1| 293|Homo sapiens EGF-like-domain, multiple
8 protein.
Length = 293
Score = 42.3 bits (95), Expect = 0.010
Identities = 16/31 (51%), Positives = 19/31 (61%)
Query: 575 CSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
CSH CFN + CGCP L L D +TC+E
Sbjct: 155 CSHHCFNTAGSFTCGCPHDLVLGVDGRTCME 185
>AL391824-1|CAI17865.1| 5635|Homo sapiens protein ( Human DNA sequence
from clone GS1-268N14 on chromosome 1. ).
Length = 5635
Score = 42.3 bits (95), Expect = 0.010
Identities = 18/36 (50%), Positives = 20/36 (55%), Gaps = 1/36 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA N CSH C N Y C CP GL + AD +TC
Sbjct: 5111 CAAGNP-CSHSCHNAMGTYYCSCPKGLTIAADGRTC 5145
Score = 40.3 bits (90), Expect = 0.041
Identities = 24/80 (30%), Positives = 34/80 (42%), Gaps = 5/80 (6%)
Query: 553 GVKAFRLGAP-LGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE----PE 607
G ++ +G P + N C C+H C N P + C CP G L D K+C P
Sbjct: 5303 GYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPN 5362
Query: 608 AFLVYSRKNIIGRLSIKNEY 627
YS N+ ++N Y
Sbjct: 5363 YGTQYSSYNLARFSPVRNNY 5382
Score = 34.7 bits (76), Expect = 2.0
Identities = 14/34 (41%), Positives = 18/34 (52%)
Query: 570 DDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
++ C H C N Y C CP G +LT + KTC
Sbjct: 5437 ENTDACQHECKNTFGSYQCICPPGYQLTHNGKTC 5470
>AL135797-1|CAI17871.1| 5635|Homo sapiens protein ( Human DNA sequence
from clone GS1-77J13 on chromosome 1. ).
Length = 5635
Score = 42.3 bits (95), Expect = 0.010
Identities = 18/36 (50%), Positives = 20/36 (55%), Gaps = 1/36 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA N CSH C N Y C CP GL + AD +TC
Sbjct: 5111 CAAGNP-CSHSCHNAMGTYYCSCPKGLTIAADGRTC 5145
Score = 40.3 bits (90), Expect = 0.041
Identities = 24/80 (30%), Positives = 34/80 (42%), Gaps = 5/80 (6%)
Query: 553 GVKAFRLGAP-LGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE----PE 607
G ++ +G P + N C C+H C N P + C CP G L D K+C P
Sbjct: 5303 GYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPN 5362
Query: 608 AFLVYSRKNIIGRLSIKNEY 627
YS N+ ++N Y
Sbjct: 5363 YGTQYSSYNLARFSPVRNNY 5382
Score = 34.7 bits (76), Expect = 2.0
Identities = 14/34 (41%), Positives = 18/34 (52%)
Query: 570 DDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
++ C H C N Y C CP G +LT + KTC
Sbjct: 5437 ENTDACQHECKNTFGSYQCICPPGYQLTHNGKTC 5470
>AL135796-1|CAI17854.1| 5635|Homo sapiens protein ( Human DNA sequence
from clone GS1-164L12 on chromosome 1. ).
Length = 5635
Score = 42.3 bits (95), Expect = 0.010
Identities = 18/36 (50%), Positives = 20/36 (55%), Gaps = 1/36 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA N CSH C N Y C CP GL + AD +TC
Sbjct: 5111 CAAGNP-CSHSCHNAMGTYYCSCPKGLTIAADGRTC 5145
Score = 40.3 bits (90), Expect = 0.041
Identities = 24/80 (30%), Positives = 34/80 (42%), Gaps = 5/80 (6%)
Query: 553 GVKAFRLGAP-LGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE----PE 607
G ++ +G P + N C C+H C N P + C CP G L D K+C P
Sbjct: 5303 GYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPN 5362
Query: 608 AFLVYSRKNIIGRLSIKNEY 627
YS N+ ++N Y
Sbjct: 5363 YGTQYSSYNLARFSPVRNNY 5382
Score = 34.7 bits (76), Expect = 2.0
Identities = 14/34 (41%), Positives = 18/34 (52%)
Query: 570 DDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
++ C H C N Y C CP G +LT + KTC
Sbjct: 5437 ENTDACQHECKNTFGSYQCICPPGYQLTHNGKTC 5470
>AL133553-2|CAI17858.1| 5635|Homo sapiens protein ( Human DNA sequence
from clone GS1-174L6 on chromosome 1. ).
Length = 5635
Score = 42.3 bits (95), Expect = 0.010
Identities = 18/36 (50%), Positives = 20/36 (55%), Gaps = 1/36 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA N CSH C N Y C CP GL + AD +TC
Sbjct: 5111 CAAGNP-CSHSCHNAMGTYYCSCPKGLTIAADGRTC 5145
Score = 40.3 bits (90), Expect = 0.041
Identities = 24/80 (30%), Positives = 34/80 (42%), Gaps = 5/80 (6%)
Query: 553 GVKAFRLGAP-LGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE----PE 607
G ++ +G P + N C C+H C N P + C CP G L D K+C P
Sbjct: 5303 GYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPN 5362
Query: 608 AFLVYSRKNIIGRLSIKNEY 627
YS N+ ++N Y
Sbjct: 5363 YGTQYSSYNLARFSPVRNNY 5382
Score = 34.7 bits (76), Expect = 2.0
Identities = 14/34 (41%), Positives = 18/34 (52%)
Query: 570 DDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
++ C H C N Y C CP G +LT + KTC
Sbjct: 5437 ENTDACQHECKNTFGSYQCICPPGYQLTHNGKTC 5470
>AL133515-1|CAI17853.1| 5635|Homo sapiens protein ( Human DNA sequence
from clone GS1-153O3 on chromosome 1. ).
Length = 5635
Score = 42.3 bits (95), Expect = 0.010
Identities = 18/36 (50%), Positives = 20/36 (55%), Gaps = 1/36 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA N CSH C N Y C CP GL + AD +TC
Sbjct: 5111 CAAGNP-CSHSCHNAMGTYYCSCPKGLTIAADGRTC 5145
Score = 40.3 bits (90), Expect = 0.041
Identities = 24/80 (30%), Positives = 34/80 (42%), Gaps = 5/80 (6%)
Query: 553 GVKAFRLGAP-LGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE----PE 607
G ++ +G P + N C C+H C N P + C CP G L D K+C P
Sbjct: 5303 GYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPN 5362
Query: 608 AFLVYSRKNIIGRLSIKNEY 627
YS N+ ++N Y
Sbjct: 5363 YGTQYSSYNLARFSPVRNNY 5382
Score = 34.7 bits (76), Expect = 2.0
Identities = 14/34 (41%), Positives = 18/34 (52%)
Query: 570 DDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
++ C H C N Y C CP G +LT + KTC
Sbjct: 5437 ENTDACQHECKNTFGSYQCICPPGYQLTHNGKTC 5470
>AL121996-1|CAI17844.1| 5635|Homo sapiens protein ( Human DNA sequence
from clone GS1-118G19 on chromosome 1q25.1-31.1. ).
Length = 5635
Score = 42.3 bits (95), Expect = 0.010
Identities = 18/36 (50%), Positives = 20/36 (55%), Gaps = 1/36 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA N CSH C N Y C CP GL + AD +TC
Sbjct: 5111 CAAGNP-CSHSCHNAMGTYYCSCPKGLTIAADGRTC 5145
Score = 40.3 bits (90), Expect = 0.041
Identities = 24/80 (30%), Positives = 34/80 (42%), Gaps = 5/80 (6%)
Query: 553 GVKAFRLGAP-LGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE----PE 607
G ++ +G P + N C C+H C N P + C CP G L D K+C P
Sbjct: 5303 GYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPN 5362
Query: 608 AFLVYSRKNIIGRLSIKNEY 627
YS N+ ++N Y
Sbjct: 5363 YGTQYSSYNLARFSPVRNNY 5382
Score = 34.7 bits (76), Expect = 2.0
Identities = 14/34 (41%), Positives = 18/34 (52%)
Query: 570 DDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
++ C H C N Y C CP G +LT + KTC
Sbjct: 5437 ENTDACQHECKNTFGSYQCICPPGYQLTHNGKTC 5470
>AL118512-1|CAI17864.1| 5635|Homo sapiens protein ( Human DNA sequence
from clone GS1-248A21 on chromosome 1q31.1-31.3. ).
Length = 5635
Score = 42.3 bits (95), Expect = 0.010
Identities = 18/36 (50%), Positives = 20/36 (55%), Gaps = 1/36 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA N CSH C N Y C CP GL + AD +TC
Sbjct: 5111 CAAGNP-CSHSCHNAMGTYYCSCPKGLTIAADGRTC 5145
Score = 40.3 bits (90), Expect = 0.041
Identities = 24/80 (30%), Positives = 34/80 (42%), Gaps = 5/80 (6%)
Query: 553 GVKAFRLGAP-LGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE----PE 607
G ++ +G P + N C C+H C N P + C CP G L D K+C P
Sbjct: 5303 GYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPN 5362
Query: 608 AFLVYSRKNIIGRLSIKNEY 627
YS N+ ++N Y
Sbjct: 5363 YGTQYSSYNLARFSPVRNNY 5382
Score = 34.7 bits (76), Expect = 2.0
Identities = 14/34 (41%), Positives = 18/34 (52%)
Query: 570 DDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
++ C H C N Y C CP G +LT + KTC
Sbjct: 5437 ENTDACQHECKNTFGSYQCICPPGYQLTHNGKTC 5470
>AK027344-1|BAB55049.1| 741|Homo sapiens protein ( Homo sapiens
cDNA FLJ14438 fis, clone HEMBB1000317, weakly similar to
FIBULIN-1, ISOFORM D PRECURSOR. ).
Length = 741
Score = 42.3 bits (95), Expect = 0.010
Identities = 18/36 (50%), Positives = 20/36 (55%), Gaps = 1/36 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA N CSH C N Y C CP GL + AD +TC
Sbjct: 334 CAAGNP-CSHSCHNAMGTYYCSCPKGLTIAADGRTC 368
Score = 35.1 bits (77), Expect = 1.5
Identities = 18/52 (34%), Positives = 27/52 (51%), Gaps = 2/52 (3%)
Query: 553 GVKAFRLGAP-LGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
G ++ +G P + + C ++ C H C N Y C CP G +LT + KTC
Sbjct: 526 GYRSQGVGRPCMDIDEC-ENTDACQHECKNTFGSYQCICPPGYQLTHNGKTC 576
>AJ306906-1|CAC37630.1| 2673|Homo sapiens fibulin-6 protein.
Length = 2673
Score = 42.3 bits (95), Expect = 0.010
Identities = 18/36 (50%), Positives = 20/36 (55%), Gaps = 1/36 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA N CSH C N Y C CP GL + AD +TC
Sbjct: 2149 CAAGNP-CSHSCHNAMGTYYCSCPKGLTIAADGRTC 2183
Score = 40.3 bits (90), Expect = 0.041
Identities = 24/80 (30%), Positives = 34/80 (42%), Gaps = 5/80 (6%)
Query: 553 GVKAFRLGAP-LGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE----PE 607
G ++ +G P + N C C+H C N P + C CP G L D K+C P
Sbjct: 2341 GYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPN 2400
Query: 608 AFLVYSRKNIIGRLSIKNEY 627
YS N+ ++N Y
Sbjct: 2401 YGTQYSSYNLARFSPVRNNY 2420
Score = 34.7 bits (76), Expect = 2.0
Identities = 14/34 (41%), Positives = 18/34 (52%)
Query: 570 DDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
++ C H C N Y C CP G +LT + KTC
Sbjct: 2475 ENTDACQHECKNTFGSYQCICPPGYQLTHNGKTC 2508
>AJ224741-1|CAA12110.1| 486|Homo sapiens matrilin-3 protein.
Length = 486
Score = 42.3 bits (95), Expect = 0.010
Identities = 18/47 (38%), Positives = 25/47 (53%), Gaps = 3/47 (6%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
++C + + GC H+C+ D Y C C Y LN+D TCS EE
Sbjct: 392 DKCALGSHGCQHICV---SDGAASYHCDCYPGYTLNEDKKTCSATEE 435
Score = 39.9 bits (89), Expect = 0.054
Identities = 17/50 (34%), Positives = 26/50 (52%), Gaps = 3/50 (6%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL 914
++C ++ GC H+C+ D Y C C Y LN+D TCS ++ L
Sbjct: 308 DRCALNTHGCEHICV---NDRSGSYHCECYEGYTLNEDRKTCSAQDKCAL 354
Score = 39.5 bits (88), Expect = 0.071
Identities = 18/37 (48%), Positives = 20/37 (54%), Gaps = 1/37 (2%)
Query: 568 CADDNGGCSHLCFN-RPDDYICGCPLGLELTADKKTC 603
CA GC H+C N R + C C G L ADKKTC
Sbjct: 352 CALGTHGCQHICVNDRTGSHHCECYEGYTLNADKKTC 388
Score = 39.1 bits (87), Expect = 0.094
Identities = 17/37 (45%), Positives = 20/37 (54%), Gaps = 1/37 (2%)
Query: 568 CADDNGGCSHLCFN-RPDDYICGCPLGLELTADKKTC 603
CA + GC H+C N R Y C C G L D+KTC
Sbjct: 310 CALNTHGCEHICVNDRSGSYHCECYEGYTLNEDRKTC 346
Score = 35.9 bits (79), Expect = 0.87
Identities = 16/50 (32%), Positives = 22/50 (44%), Gaps = 3/50 (6%)
Query: 858 RAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS 907
R ++C + GC H+C+ D + C C Y LN D TCS
Sbjct: 343 RKTCSAQDKCALGTHGCQHICV---NDRTGSHHCECYEGYTLNADKKTCS 389
Score = 35.5 bits (78), Expect = 1.2
Identities = 17/41 (41%), Positives = 20/41 (48%), Gaps = 1/41 (2%)
Query: 568 CADDNGGCSHLCFNR-PDDYICGCPLGLELTADKKTCVEPE 607
CA + GC H+C + Y C C G L DKKTC E
Sbjct: 394 CALGSHGCQHICVSDGAASYHCDCYPGYTLNEDKKTCSATE 434
Score = 34.7 bits (76), Expect = 2.0
Identities = 15/39 (38%), Positives = 20/39 (51%), Gaps = 1/39 (2%)
Query: 566 NPCADDNGGCSHLCFNRPDD-YICGCPLGLELTADKKTC 603
+PC C H+C + + + C C G L ADKKTC
Sbjct: 266 DPCVLGTHQCQHVCISDGEGKHHCECSQGYTLNADKKTC 304
>AJ001047-1|CAA04501.1| 303|Homo sapiens Matrilin-3 protein.
Length = 303
Score = 42.3 bits (95), Expect = 0.010
Identities = 18/47 (38%), Positives = 25/47 (53%), Gaps = 3/47 (6%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
++C + + GC H+C+ D Y C C Y LN+D TCS EE
Sbjct: 209 DKCALGSHGCQHICV---SDGAASYHCDCYPGYTLNEDKKTCSATEE 252
Score = 39.9 bits (89), Expect = 0.054
Identities = 17/50 (34%), Positives = 26/50 (52%), Gaps = 3/50 (6%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL 914
++C ++ GC H+C+ D Y C C Y LN+D TCS ++ L
Sbjct: 125 DRCALNTHGCEHICV---NDRSGSYHCECYEGYTLNEDRKTCSAQDKCAL 171
Score = 39.5 bits (88), Expect = 0.071
Identities = 18/37 (48%), Positives = 20/37 (54%), Gaps = 1/37 (2%)
Query: 568 CADDNGGCSHLCFN-RPDDYICGCPLGLELTADKKTC 603
CA GC H+C N R + C C G L ADKKTC
Sbjct: 169 CALGTHGCQHICVNDRTGSHHCECYEGYTLNADKKTC 205
Score = 39.1 bits (87), Expect = 0.094
Identities = 17/37 (45%), Positives = 20/37 (54%), Gaps = 1/37 (2%)
Query: 568 CADDNGGCSHLCFN-RPDDYICGCPLGLELTADKKTC 603
CA + GC H+C N R Y C C G L D+KTC
Sbjct: 127 CALNTHGCEHICVNDRSGSYHCECYEGYTLNEDRKTC 163
Score = 35.9 bits (79), Expect = 0.87
Identities = 16/50 (32%), Positives = 22/50 (44%), Gaps = 3/50 (6%)
Query: 858 RAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS 907
R ++C + GC H+C+ D + C C Y LN D TCS
Sbjct: 160 RKTCSAQDKCALGTHGCQHICV---NDRTGSHHCECYEGYTLNADKKTCS 206
Score = 35.5 bits (78), Expect = 1.2
Identities = 17/41 (41%), Positives = 20/41 (48%), Gaps = 1/41 (2%)
Query: 568 CADDNGGCSHLCFNR-PDDYICGCPLGLELTADKKTCVEPE 607
CA + GC H+C + Y C C G L DKKTC E
Sbjct: 211 CALGSHGCQHICVSDGAASYHCDCYPGYTLNEDKKTCSATE 251
Score = 34.7 bits (76), Expect = 2.0
Identities = 15/39 (38%), Positives = 20/39 (51%), Gaps = 1/39 (2%)
Query: 566 NPCADDNGGCSHLCFNRPDD-YICGCPLGLELTADKKTC 603
+PC C H+C + + + C C G L ADKKTC
Sbjct: 83 DPCVLGTHQCQHVCISDGEGKHHCECSQGYTLNADKKTC 121
>AF156100-1|AAK68690.1| 5636|Homo sapiens hemicentin protein.
Length = 5636
Score = 42.3 bits (95), Expect = 0.010
Identities = 18/36 (50%), Positives = 20/36 (55%), Gaps = 1/36 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA N CSH C N Y C CP GL + AD +TC
Sbjct: 5112 CAAGNP-CSHSCHNAMGTYYCSCPKGLTIAADGRTC 5146
Score = 38.3 bits (85), Expect = 0.16
Identities = 23/80 (28%), Positives = 34/80 (42%), Gaps = 5/80 (6%)
Query: 553 GVKAFRLGAP-LGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE----PE 607
G ++ +G P + + C C+H C N P + C CP G L D K+C P
Sbjct: 5304 GYRSQGVGRPCMDIDECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPN 5363
Query: 608 AFLVYSRKNIIGRLSIKNEY 627
YS N+ ++N Y
Sbjct: 5364 YGTQYSSYNLARFSPVRNNY 5383
Score = 34.7 bits (76), Expect = 2.0
Identities = 14/34 (41%), Positives = 18/34 (52%)
Query: 570 DDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
++ C H C N Y C CP G +LT + KTC
Sbjct: 5438 ENTDACQHECKNTFGSYQCICPPGYQLTHNGKTC 5471
>AC079145-2|AAX88937.1| 486|Homo sapiens unknown protein.
Length = 486
Score = 42.3 bits (95), Expect = 0.010
Identities = 18/47 (38%), Positives = 25/47 (53%), Gaps = 3/47 (6%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
++C + + GC H+C+ D Y C C Y LN+D TCS EE
Sbjct: 392 DKCALGSHGCQHICV---SDGAASYHCDCYPGYTLNEDKKTCSATEE 435
Score = 39.9 bits (89), Expect = 0.054
Identities = 17/50 (34%), Positives = 26/50 (52%), Gaps = 3/50 (6%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLL 914
++C ++ GC H+C+ D Y C C Y LN+D TCS ++ L
Sbjct: 308 DRCALNTHGCEHICV---NDRSGSYHCECYEGYTLNEDRKTCSAQDKCAL 354
Score = 39.5 bits (88), Expect = 0.071
Identities = 18/37 (48%), Positives = 20/37 (54%), Gaps = 1/37 (2%)
Query: 568 CADDNGGCSHLCFN-RPDDYICGCPLGLELTADKKTC 603
CA GC H+C N R + C C G L ADKKTC
Sbjct: 352 CALGTHGCQHICVNDRTGSHHCECYEGYTLNADKKTC 388
Score = 39.1 bits (87), Expect = 0.094
Identities = 17/37 (45%), Positives = 20/37 (54%), Gaps = 1/37 (2%)
Query: 568 CADDNGGCSHLCFN-RPDDYICGCPLGLELTADKKTC 603
CA + GC H+C N R Y C C G L D+KTC
Sbjct: 310 CALNTHGCEHICVNDRSGSYHCECYEGYTLNEDRKTC 346
Score = 35.9 bits (79), Expect = 0.87
Identities = 16/50 (32%), Positives = 22/50 (44%), Gaps = 3/50 (6%)
Query: 858 RAKSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCS 907
R ++C + GC H+C+ D + C C Y LN D TCS
Sbjct: 343 RKTCSAQDKCALGTHGCQHICV---NDRTGSHHCECYEGYTLNADKKTCS 389
Score = 35.5 bits (78), Expect = 1.2
Identities = 17/41 (41%), Positives = 20/41 (48%), Gaps = 1/41 (2%)
Query: 568 CADDNGGCSHLCFNR-PDDYICGCPLGLELTADKKTCVEPE 607
CA + GC H+C + Y C C G L DKKTC E
Sbjct: 394 CALGSHGCQHICVSDGAASYHCDCYPGYTLNEDKKTCSATE 434
Score = 34.7 bits (76), Expect = 2.0
Identities = 15/39 (38%), Positives = 20/39 (51%), Gaps = 1/39 (2%)
Query: 566 NPCADDNGGCSHLCFNRPDD-YICGCPLGLELTADKKTC 603
+PC C H+C + + + C C G L ADKKTC
Sbjct: 266 DPCVLGTHQCQHVCISDGEGKHHCECSQGYTLNADKKTC 304
>AB190520-1|BAD51398.1| 293|Homo sapiens VE-statin2 protein.
Length = 293
Score = 42.3 bits (95), Expect = 0.010
Identities = 16/31 (51%), Positives = 19/31 (61%)
Query: 575 CSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
CSH CFN + CGCP L L D +TC+E
Sbjct: 155 CSHHCFNTAGSFTCGCPHDLVLGVDGRTCME 185
>AB177800-1|BAD16736.1| 2809|Homo sapiens fibrillin 3 protein.
Length = 2809
Score = 42.3 bits (95), Expect = 0.010
Identities = 19/47 (40%), Positives = 25/47 (53%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
N+C V NGGC C+ T G YRC+C Y L D C++ +E
Sbjct: 1157 NECRVQNGGCDVHCINTEG----SYRCSCGQGYSLMPDGRACADVDE 1199
Score = 39.1 bits (87), Expect = 0.094
Identities = 16/43 (37%), Positives = 20/43 (46%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEA 608
N CAD + +C N P Y+C CP EL CV+ A
Sbjct: 1447 NECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRA 1489
Score = 38.7 bits (86), Expect = 0.12
Identities = 19/51 (37%), Positives = 24/51 (47%), Gaps = 1/51 (1%)
Query: 559 LGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAF 609
LG + CA G CS+ C N P ++CGCP G A + CV F
Sbjct: 2605 LGGCQDVDECAGRRGPCSYSCANTPGGFLCGCPQGY-FRAGQGHCVSGLGF 2654
Score = 38.3 bits (85), Expect = 0.16
Identities = 15/40 (37%), Positives = 17/40 (42%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
N C NGGC C N Y C C G L D + C +
Sbjct: 1157 NECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACAD 1196
Score = 35.9 bits (79), Expect = 0.87
Identities = 18/54 (33%), Positives = 27/54 (50%), Gaps = 1/54 (1%)
Query: 553 GVKAFRLGAPLGWNPCADDNGGCSHL-CFNRPDDYICGCPLGLELTADKKTCVE 605
G K GA +G N C + CSH C + Y+C C G + +AD+ C++
Sbjct: 1794 GYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMD 1847
Score = 35.1 bits (77), Expect = 1.5
Identities = 14/41 (34%), Positives = 20/41 (48%)
Query: 563 LGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
L + C+ C+ LC N ++C CP G L D +TC
Sbjct: 2404 LDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTC 2444
Score = 33.5 bits (73), Expect = 4.7
Identities = 16/48 (33%), Positives = 26/48 (54%), Gaps = 5/48 (10%)
Query: 865 NQCGVDNGGCSH-LCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
N+C + G C++ +C+ T G +RC CP Y L+ I C + +E
Sbjct: 2086 NECAENPGVCTNGVCVNTDGS----FRCECPFGYSLDFTGINCVDTDE 2129
Score = 33.5 bits (73), Expect = 4.7
Identities = 14/43 (32%), Positives = 22/43 (51%), Gaps = 1/43 (2%)
Query: 566 NPCADDNGGCSH-LCFNRPDDYICGCPLGLELTADKKTCVEPE 607
N CA++ G C++ +C N + C CP G L CV+ +
Sbjct: 2086 NECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTD 2128
Score = 33.1 bits (72), Expect = 6.2
Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 2/36 (5%)
Query: 572 NGGCSHL--CFNRPDDYICGCPLGLELTADKKTCVE 605
+GG HL C N + C C G EL+ D K CV+
Sbjct: 496 SGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVD 531
>AB177799-1|BAD16735.1| 2809|Homo sapiens fibrillin 3 protein.
Length = 2809
Score = 42.3 bits (95), Expect = 0.010
Identities = 19/47 (40%), Positives = 25/47 (53%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
N+C V NGGC C+ T G YRC+C Y L D C++ +E
Sbjct: 1157 NECRVQNGGCDVHCINTEG----SYRCSCGQGYSLMPDGRACADVDE 1199
Score = 39.1 bits (87), Expect = 0.094
Identities = 16/43 (37%), Positives = 20/43 (46%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEA 608
N CAD + +C N P Y+C CP EL CV+ A
Sbjct: 1447 NECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRA 1489
Score = 38.7 bits (86), Expect = 0.12
Identities = 19/51 (37%), Positives = 24/51 (47%), Gaps = 1/51 (1%)
Query: 559 LGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAF 609
LG + CA G CS+ C N P ++CGCP G A + CV F
Sbjct: 2605 LGGCQDVDECAGRRGPCSYSCANTPGGFLCGCPQGY-FRAGQGHCVSGLGF 2654
Score = 38.3 bits (85), Expect = 0.16
Identities = 15/40 (37%), Positives = 17/40 (42%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
N C NGGC C N Y C C G L D + C +
Sbjct: 1157 NECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACAD 1196
Score = 35.9 bits (79), Expect = 0.87
Identities = 18/54 (33%), Positives = 27/54 (50%), Gaps = 1/54 (1%)
Query: 553 GVKAFRLGAPLGWNPCADDNGGCSHL-CFNRPDDYICGCPLGLELTADKKTCVE 605
G K GA +G N C + CSH C + Y+C C G + +AD+ C++
Sbjct: 1794 GYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMD 1847
Score = 35.1 bits (77), Expect = 1.5
Identities = 14/41 (34%), Positives = 20/41 (48%)
Query: 563 LGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
L + C+ C+ LC N ++C CP G L D +TC
Sbjct: 2404 LDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTC 2444
Score = 33.5 bits (73), Expect = 4.7
Identities = 16/48 (33%), Positives = 26/48 (54%), Gaps = 5/48 (10%)
Query: 865 NQCGVDNGGCSH-LCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
N+C + G C++ +C+ T G +RC CP Y L+ I C + +E
Sbjct: 2086 NECAENPGVCTNGVCVNTDGS----FRCECPFGYSLDFTGINCVDTDE 2129
Score = 33.5 bits (73), Expect = 4.7
Identities = 14/43 (32%), Positives = 22/43 (51%), Gaps = 1/43 (2%)
Query: 566 NPCADDNGGCSH-LCFNRPDDYICGCPLGLELTADKKTCVEPE 607
N CA++ G C++ +C N + C CP G L CV+ +
Sbjct: 2086 NECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTD 2128
Score = 33.1 bits (72), Expect = 6.2
Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 2/36 (5%)
Query: 572 NGGCSHL--CFNRPDDYICGCPLGLELTADKKTCVE 605
+GG HL C N + C C G EL+ D K CV+
Sbjct: 496 SGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVD 531
>AB177798-1|BAD16734.1| 2809|Homo sapiens fibrillin 3 protein.
Length = 2809
Score = 42.3 bits (95), Expect = 0.010
Identities = 19/47 (40%), Positives = 25/47 (53%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
N+C V NGGC C+ T G YRC+C Y L D C++ +E
Sbjct: 1157 NECRVQNGGCDVHCINTEG----SYRCSCGQGYSLMPDGRACADVDE 1199
Score = 39.1 bits (87), Expect = 0.094
Identities = 16/43 (37%), Positives = 20/43 (46%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEA 608
N CAD + +C N P Y+C CP EL CV+ A
Sbjct: 1447 NECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRA 1489
Score = 38.7 bits (86), Expect = 0.12
Identities = 19/51 (37%), Positives = 24/51 (47%), Gaps = 1/51 (1%)
Query: 559 LGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAF 609
LG + CA G CS+ C N P ++CGCP G A + CV F
Sbjct: 2605 LGGCQDVDECAGRRGPCSYSCANTPGGFLCGCPQGY-FRAGQGHCVSGLGF 2654
Score = 38.3 bits (85), Expect = 0.16
Identities = 15/40 (37%), Positives = 17/40 (42%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
N C NGGC C N Y C C G L D + C +
Sbjct: 1157 NECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACAD 1196
Score = 35.9 bits (79), Expect = 0.87
Identities = 18/54 (33%), Positives = 27/54 (50%), Gaps = 1/54 (1%)
Query: 553 GVKAFRLGAPLGWNPCADDNGGCSHL-CFNRPDDYICGCPLGLELTADKKTCVE 605
G K GA +G N C + CSH C + Y+C C G + +AD+ C++
Sbjct: 1794 GYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMD 1847
Score = 35.1 bits (77), Expect = 1.5
Identities = 14/41 (34%), Positives = 20/41 (48%)
Query: 563 LGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
L + C+ C+ LC N ++C CP G L D +TC
Sbjct: 2404 LDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTC 2444
Score = 33.5 bits (73), Expect = 4.7
Identities = 16/48 (33%), Positives = 26/48 (54%), Gaps = 5/48 (10%)
Query: 865 NQCGVDNGGCSH-LCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
N+C + G C++ +C+ T G +RC CP Y L+ I C + +E
Sbjct: 2086 NECAENPGVCTNGVCVNTDGS----FRCECPFGYSLDFTGINCVDTDE 2129
Score = 33.5 bits (73), Expect = 4.7
Identities = 14/43 (32%), Positives = 22/43 (51%), Gaps = 1/43 (2%)
Query: 566 NPCADDNGGCSH-LCFNRPDDYICGCPLGLELTADKKTCVEPE 607
N CA++ G C++ +C N + C CP G L CV+ +
Sbjct: 2086 NECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTD 2128
Score = 33.1 bits (72), Expect = 6.2
Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 2/36 (5%)
Query: 572 NGGCSHL--CFNRPDDYICGCPLGLELTADKKTCVE 605
+GG HL C N + C C G EL+ D K CV+
Sbjct: 496 SGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVD 531
>AB177797-1|BAD16733.1| 2809|Homo sapiens fibrillin 3 protein.
Length = 2809
Score = 42.3 bits (95), Expect = 0.010
Identities = 19/47 (40%), Positives = 25/47 (53%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
N+C V NGGC C+ T G YRC+C Y L D C++ +E
Sbjct: 1157 NECRVQNGGCDVHCINTEG----SYRCSCGQGYSLMPDGRACADVDE 1199
Score = 39.1 bits (87), Expect = 0.094
Identities = 16/43 (37%), Positives = 20/43 (46%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEA 608
N CAD + +C N P Y+C CP EL CV+ A
Sbjct: 1447 NECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRA 1489
Score = 38.7 bits (86), Expect = 0.12
Identities = 19/51 (37%), Positives = 24/51 (47%), Gaps = 1/51 (1%)
Query: 559 LGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAF 609
LG + CA G CS+ C N P ++CGCP G A + CV F
Sbjct: 2605 LGGCQDVDECAGRRGPCSYSCANTPGGFLCGCPQGY-FRAGQGHCVSGLGF 2654
Score = 38.3 bits (85), Expect = 0.16
Identities = 15/40 (37%), Positives = 17/40 (42%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
N C NGGC C N Y C C G L D + C +
Sbjct: 1157 NECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACAD 1196
Score = 35.9 bits (79), Expect = 0.87
Identities = 18/54 (33%), Positives = 27/54 (50%), Gaps = 1/54 (1%)
Query: 553 GVKAFRLGAPLGWNPCADDNGGCSHL-CFNRPDDYICGCPLGLELTADKKTCVE 605
G K GA +G N C + CSH C + Y+C C G + +AD+ C++
Sbjct: 1794 GYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMD 1847
Score = 35.1 bits (77), Expect = 1.5
Identities = 14/41 (34%), Positives = 20/41 (48%)
Query: 563 LGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
L + C+ C+ LC N ++C CP G L D +TC
Sbjct: 2404 LDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTC 2444
Score = 33.5 bits (73), Expect = 4.7
Identities = 16/48 (33%), Positives = 26/48 (54%), Gaps = 5/48 (10%)
Query: 865 NQCGVDNGGCSH-LCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
N+C + G C++ +C+ T G +RC CP Y L+ I C + +E
Sbjct: 2086 NECAENPGVCTNGVCVNTDGS----FRCECPFGYSLDFTGINCVDTDE 2129
Score = 33.5 bits (73), Expect = 4.7
Identities = 14/43 (32%), Positives = 22/43 (51%), Gaps = 1/43 (2%)
Query: 566 NPCADDNGGCSH-LCFNRPDDYICGCPLGLELTADKKTCVEPE 607
N CA++ G C++ +C N + C CP G L CV+ +
Sbjct: 2086 NECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTD 2128
Score = 33.1 bits (72), Expect = 6.2
Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 2/36 (5%)
Query: 572 NGGCSHL--CFNRPDDYICGCPLGLELTADKKTCVE 605
+GG HL C N + C C G EL+ D K CV+
Sbjct: 496 SGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVD 531
>AB053450-1|BAB47408.2| 2816|Homo sapiens fibrillin3 protein.
Length = 2816
Score = 42.3 bits (95), Expect = 0.010
Identities = 19/47 (40%), Positives = 25/47 (53%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
N+C V NGGC C+ T G YRC+C Y L D C++ +E
Sbjct: 1164 NECRVQNGGCDVHCINTEG----SYRCSCGQGYSLMPDGRACADVDE 1206
Score = 39.1 bits (87), Expect = 0.094
Identities = 16/43 (37%), Positives = 20/43 (46%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEA 608
N CAD + +C N P Y+C CP EL CV+ A
Sbjct: 1454 NECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRA 1496
Score = 38.7 bits (86), Expect = 0.12
Identities = 19/51 (37%), Positives = 24/51 (47%), Gaps = 1/51 (1%)
Query: 559 LGAPLGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPEAF 609
LG + CA G CS+ C N P ++CGCP G A + CV F
Sbjct: 2612 LGGCQDVDECAGRRGPCSYSCANTPGGFLCGCPQGY-FRAGQGHCVSGLGF 2661
Score = 38.3 bits (85), Expect = 0.16
Identities = 15/40 (37%), Positives = 17/40 (42%)
Query: 566 NPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
N C NGGC C N Y C C G L D + C +
Sbjct: 1164 NECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACAD 1203
Score = 36.3 bits (80), Expect = 0.66
Identities = 18/54 (33%), Positives = 27/54 (50%), Gaps = 1/54 (1%)
Query: 553 GVKAFRLGAPLGWNPCADDNGGCSHL-CFNRPDDYICGCPLGLELTADKKTCVE 605
G K GA +G N C + CSH C + Y+C C G + +AD+ C++
Sbjct: 1801 GYKLSPGGACVGQNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMD 1854
Score = 35.1 bits (77), Expect = 1.5
Identities = 14/41 (34%), Positives = 20/41 (48%)
Query: 563 LGWNPCADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
L + C+ C+ LC N ++C CP G L D +TC
Sbjct: 2411 LDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTC 2451
Score = 33.5 bits (73), Expect = 4.7
Identities = 16/48 (33%), Positives = 26/48 (54%), Gaps = 5/48 (10%)
Query: 865 NQCGVDNGGCSH-LCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
N+C + G C++ +C+ T G +RC CP Y L+ I C + +E
Sbjct: 2093 NECAENPGVCTNGVCVNTDGS----FRCECPFGYSLDFTGINCVDTDE 2136
Score = 33.5 bits (73), Expect = 4.7
Identities = 14/43 (32%), Positives = 22/43 (51%), Gaps = 1/43 (2%)
Query: 566 NPCADDNGGCSH-LCFNRPDDYICGCPLGLELTADKKTCVEPE 607
N CA++ G C++ +C N + C CP G L CV+ +
Sbjct: 2093 NECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTD 2135
Score = 33.1 bits (72), Expect = 6.2
Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 2/36 (5%)
Query: 572 NGGCSHL--CFNRPDDYICGCPLGLELTADKKTCVE 605
+GG HL C N + C C G EL+ D K CV+
Sbjct: 503 SGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVD 538
>Z97832-1|CAI20187.1| 993|Homo sapiens protein ( Human DNA sequence
from clone RP3-329A5 on chromosome 6p21.1-21.33. ).
Length = 993
Score = 41.9 bits (94), Expect = 0.013
Identities = 19/50 (38%), Positives = 26/50 (52%), Gaps = 1/50 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE-PEAFLVYSRKN 616
CA+ NGGC C N Y C C G L+ ++ TC++ PE + KN
Sbjct: 116 CAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKN 165
Score = 41.5 bits (93), Expect = 0.018
Identities = 16/36 (44%), Positives = 20/36 (55%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA +NGGC C + C CP+G L D+KTC
Sbjct: 240 CAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTC 275
Score = 40.3 bits (90), Expect = 0.041
Identities = 18/46 (39%), Positives = 27/46 (58%), Gaps = 5/46 (10%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPA-HYRLNKDNITCSEP 909
++C ++ GGC C+ TPG Y+C CPA RL+ + C+EP
Sbjct: 359 DECSINRGGCRFGCINTPG----SYQCTCPAGQGRLHWNGKDCTEP 400
Score = 39.5 bits (88), Expect = 0.071
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
C NGGC H C + CGC + L D KTC+E
Sbjct: 201 CNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIE 238
Score = 39.1 bits (87), Expect = 0.094
Identities = 17/45 (37%), Positives = 21/45 (46%), Gaps = 4/45 (8%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
C V+NGGC C D T C CP + L D TC + +E
Sbjct: 240 CAVNNGGCDSKC----HDAATGVHCTCPVGFMLQPDRKTCKDIDE 280
Score = 38.7 bits (86), Expect = 0.12
Identities = 13/36 (36%), Positives = 20/36 (55%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
C +NGGC H+C N + C C G +L +++ C
Sbjct: 281 CRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNC 316
Score = 38.3 bits (85), Expect = 0.16
Identities = 15/36 (41%), Positives = 19/36 (52%)
Query: 570 DDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
+DN GC H C N P +Y C C G L D C++
Sbjct: 77 EDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLD 112
Score = 38.3 bits (85), Expect = 0.16
Identities = 17/40 (42%), Positives = 20/40 (50%), Gaps = 1/40 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGL-ELTADKKTCVEP 606
C+ + GGC C N P Y C CP G L + K C EP
Sbjct: 361 CSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEP 400
Score = 37.9 bits (84), Expect = 0.22
Identities = 15/47 (31%), Positives = 26/47 (55%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
++C ++NGGC H+C T G + C+C Y+L + C + +E
Sbjct: 279 DECRLNNGGCDHICRNTVG----SFECSCKKGYKLLINERNCQDIDE 321
Score = 36.3 bits (80), Expect = 0.66
Identities = 15/37 (40%), Positives = 21/37 (56%), Gaps = 1/37 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYI-CGCPLGLELTADKKTC 603
C + N GC+H+C P I C C G ELT +++ C
Sbjct: 161 CMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDC 197
Score = 35.1 bits (77), Expect = 1.5
Identities = 16/42 (38%), Positives = 21/42 (50%), Gaps = 4/42 (9%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
DN GC H C+ PG +YRC C + L D C + +E
Sbjct: 78 DNAGCVHDCVNIPG----NYRCTCYDGFHLAHDGHNCLDVDE 115
Score = 34.7 bits (76), Expect = 2.0
Identities = 16/42 (38%), Positives = 18/42 (42%), Gaps = 4/42 (9%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSE 908
C NGGC H C D RC C + L+ D TC E
Sbjct: 201 CNYGNGGCQHTC----DDTEQGPRCGCHIKFVLHTDGKTCIE 238
Score = 33.1 bits (72), Expect = 6.2
Identities = 18/56 (32%), Positives = 25/56 (44%), Gaps = 5/56 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC-SEPEEFLLFAQKN 919
++C NGGC C+ G Y C C + L+ + TC PEE + KN
Sbjct: 114 DECAEGNGGCQQSCVNMMG----SYECHCREGFFLSDNQHTCIQRPEEGMNCMNKN 165
Score = 33.1 bits (72), Expect = 6.2
Identities = 15/41 (36%), Positives = 20/41 (48%), Gaps = 3/41 (7%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYD 300
C+ NN GC H+C + + C+C G KL N C D
Sbjct: 281 CRLNNGGCDHICRNTVG--SFECSCKKGYKLLIN-ERNCQD 318
>Y19124-1|CAB65555.1| 1019|Homo sapiens enteropeptidase protein.
Length = 1019
Score = 41.9 bits (94), Expect = 0.013
Identities = 18/45 (40%), Positives = 23/45 (51%)
Query: 1146 DAFRCDEGLCIAARFVCDGRPQCADGSDEAPAACAYGHTDQVNGI 1190
D F+C G C+ +CDG C DGSDEA + T NG+
Sbjct: 646 DHFQCKNGECVPLVNLCDGHLHCEDGSDEADCVRFFNGTTNNNGL 690
Score = 35.1 bits (77), Expect = 1.5
Identities = 16/32 (50%), Positives = 17/32 (53%), Gaps = 1/32 (3%)
Query: 1150 CDEGL-CIAARFVCDGRPQCADGSDEAPAACA 1180
C + L CI A CDG C DGSDE CA
Sbjct: 191 CTDALTCIKADLFCDGEVNCPDGSDEDNKMCA 222
>U09860-1|AAC50138.1| 1019|Homo sapiens enterokinase protein.
Length = 1019
Score = 41.9 bits (94), Expect = 0.013
Identities = 18/45 (40%), Positives = 23/45 (51%)
Query: 1146 DAFRCDEGLCIAARFVCDGRPQCADGSDEAPAACAYGHTDQVNGI 1190
D F+C G C+ +CDG C DGSDEA + T NG+
Sbjct: 646 DHFQCKNGECVPLVNLCDGHLHCEDGSDEADCVRFFNGTTNNNGL 690
Score = 35.1 bits (77), Expect = 1.5
Identities = 16/32 (50%), Positives = 17/32 (53%), Gaps = 1/32 (3%)
Query: 1150 CDEGL-CIAARFVCDGRPQCADGSDEAPAACA 1180
C + L CI A CDG C DGSDE CA
Sbjct: 191 CTDALTCIKADLFCDGEVNCPDGSDEDNKMCA 222
>BT007425-1|AAP36093.1| 513|Homo sapiens serine protease inhibitor,
Kunitz type 1 protein.
Length = 513
Score = 41.9 bits (94), Expect = 0.013
Identities = 19/46 (41%), Positives = 22/46 (47%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAACAYGHTDQVNGIHPP 1193
FRC G CI + CD P C D SDEA D++ IH P
Sbjct: 324 FRCSNGCCIDSFLECDDTPNCPDASDEAACEKYTSGFDELQRIHFP 369
>BC111749-1|AAI11750.1| 1019|Homo sapiens protease, serine, 7
(enterokinase) protein.
Length = 1019
Score = 41.9 bits (94), Expect = 0.013
Identities = 18/45 (40%), Positives = 23/45 (51%)
Query: 1146 DAFRCDEGLCIAARFVCDGRPQCADGSDEAPAACAYGHTDQVNGI 1190
D F+C G C+ +CDG C DGSDEA + T NG+
Sbjct: 646 DHFQCKNGECVPLVNLCDGHLHCEDGSDEADCVRFFNGTTNNNGL 690
Score = 35.1 bits (77), Expect = 1.5
Identities = 16/32 (50%), Positives = 17/32 (53%), Gaps = 1/32 (3%)
Query: 1150 CDEGL-CIAARFVCDGRPQCADGSDEAPAACA 1180
C + L CI A CDG C DGSDE CA
Sbjct: 191 CTDALTCIKADLFCDGEVNCPDGSDEDNKMCA 222
>BC047916-1|AAH47916.1| 347|Homo sapiens SCUBE1 protein protein.
Length = 347
Score = 41.9 bits (94), Expect = 0.013
Identities = 15/37 (40%), Positives = 21/37 (56%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
C D+NGGC +C N Y C C G L+ ++ TC+
Sbjct: 121 CQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCI 157
Score = 41.1 bits (92), Expect = 0.023
Identities = 16/36 (44%), Positives = 19/36 (52%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA +NGGC C + C CP+G L D KTC
Sbjct: 275 CAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTC 310
Score = 39.9 bits (89), Expect = 0.054
Identities = 17/40 (42%), Positives = 20/40 (50%), Gaps = 4/40 (10%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC 906
C V+NGGC C D T RC+CP + L D TC
Sbjct: 275 CAVNNGGCDRTCK----DTATGVRCSCPVGFTLQPDGKTC 310
Score = 38.3 bits (85), Expect = 0.16
Identities = 18/45 (40%), Positives = 20/45 (44%), Gaps = 4/45 (8%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
C NGGC H C D T C C Y L+ D TC E +E
Sbjct: 206 CNYGNGGCQHSC----EDTDTGPTCGCHQKYALHSDGRTCIEKDE 246
Score = 37.9 bits (84), Expect = 0.22
Identities = 17/40 (42%), Positives = 21/40 (52%), Gaps = 2/40 (5%)
Query: 568 CADD--NGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
C +D NGGC H C N P +Y C C G L D C++
Sbjct: 78 CENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLD 117
Score = 37.5 bits (83), Expect = 0.29
Identities = 15/40 (37%), Positives = 20/40 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVEPE 607
C NGGC H C + CGC L +D +TC+E +
Sbjct: 206 CNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIEKD 245
Score = 35.1 bits (77), Expect = 1.5
Identities = 16/41 (39%), Positives = 21/41 (51%), Gaps = 4/41 (9%)
Query: 871 NGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
NGGC H C+ PG +YRC C + L D C + +E
Sbjct: 84 NGGCVHECINIPG----NYRCTCFDGFMLAHDGHNCLDVDE 120
Score = 33.1 bits (72), Expect = 6.2
Identities = 14/42 (33%), Positives = 21/42 (50%), Gaps = 2/42 (4%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYDS 301
C+ NN GC +C+ + Y C C +G L +N T + S
Sbjct: 121 CQDNNGGCQQICVNAMG--SYECQCHSGFFLSDNQHTCIHRS 160
>BC018702-1|AAH18702.1| 513|Homo sapiens serine peptidase inhibitor,
Kunitz type 1 protein.
Length = 513
Score = 41.9 bits (94), Expect = 0.013
Identities = 19/46 (41%), Positives = 22/46 (47%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAACAYGHTDQVNGIHPP 1193
FRC G CI + CD P C D SDEA D++ IH P
Sbjct: 324 FRCSNGCCIDSFLECDDTPNCPDASDEAACEKYTSGFDELQRIHFP 369
>BC004140-1|AAH04140.1| 513|Homo sapiens serine peptidase inhibitor,
Kunitz type 1 protein.
Length = 513
Score = 41.9 bits (94), Expect = 0.013
Identities = 19/46 (41%), Positives = 22/46 (47%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAACAYGHTDQVNGIHPP 1193
FRC G CI + CD P C D SDEA D++ IH P
Sbjct: 324 FRCSNGCCIDSFLECDDTPNCPDASDEAACEKYTSGFDELQRIHFP 369
>AY639608-1|AAU08347.1| 993|Homo sapiens signal peptide, CUB and
EGF-like domain containing protein 3 protein.
Length = 993
Score = 41.9 bits (94), Expect = 0.013
Identities = 19/50 (38%), Positives = 26/50 (52%), Gaps = 1/50 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE-PEAFLVYSRKN 616
CA+ NGGC C N Y C C G L+ ++ TC++ PE + KN
Sbjct: 116 CAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKN 165
Score = 41.5 bits (93), Expect = 0.018
Identities = 16/36 (44%), Positives = 20/36 (55%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA +NGGC C + C CP+G L D+KTC
Sbjct: 240 CAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTC 275
Score = 40.3 bits (90), Expect = 0.041
Identities = 18/46 (39%), Positives = 27/46 (58%), Gaps = 5/46 (10%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPA-HYRLNKDNITCSEP 909
++C ++ GGC C+ TPG Y+C CPA RL+ + C+EP
Sbjct: 359 DECSINRGGCRFGCINTPG----SYQCTCPAGQGRLHWNGKDCTEP 400
Score = 39.5 bits (88), Expect = 0.071
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
C NGGC H C + CGC + L D KTC+E
Sbjct: 201 CNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIE 238
Score = 39.1 bits (87), Expect = 0.094
Identities = 17/45 (37%), Positives = 21/45 (46%), Gaps = 4/45 (8%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
C V+NGGC C D T C CP + L D TC + +E
Sbjct: 240 CAVNNGGCDSKC----HDAATGVHCTCPVGFMLQPDRKTCKDIDE 280
Score = 38.7 bits (86), Expect = 0.12
Identities = 13/36 (36%), Positives = 20/36 (55%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
C +NGGC H+C N + C C G +L +++ C
Sbjct: 281 CRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNC 316
Score = 38.3 bits (85), Expect = 0.16
Identities = 15/36 (41%), Positives = 19/36 (52%)
Query: 570 DDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
+DN GC H C N P +Y C C G L D C++
Sbjct: 77 EDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLD 112
Score = 38.3 bits (85), Expect = 0.16
Identities = 17/40 (42%), Positives = 20/40 (50%), Gaps = 1/40 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGL-ELTADKKTCVEP 606
C+ + GGC C N P Y C CP G L + K C EP
Sbjct: 361 CSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEP 400
Score = 37.9 bits (84), Expect = 0.22
Identities = 15/47 (31%), Positives = 26/47 (55%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
++C ++NGGC H+C T G + C+C Y+L + C + +E
Sbjct: 279 DECRLNNGGCDHICRNTVG----SFECSCKKGYKLLINERNCQDIDE 321
Score = 36.3 bits (80), Expect = 0.66
Identities = 15/37 (40%), Positives = 21/37 (56%), Gaps = 1/37 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYI-CGCPLGLELTADKKTC 603
C + N GC+H+C P I C C G ELT +++ C
Sbjct: 161 CMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDC 197
Score = 35.1 bits (77), Expect = 1.5
Identities = 16/42 (38%), Positives = 21/42 (50%), Gaps = 4/42 (9%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
DN GC H C+ PG +YRC C + L D C + +E
Sbjct: 78 DNAGCVHDCVNIPG----NYRCTCYDGFHLAHDGHNCLDVDE 115
Score = 34.7 bits (76), Expect = 2.0
Identities = 16/42 (38%), Positives = 18/42 (42%), Gaps = 4/42 (9%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSE 908
C NGGC H C D RC C + L+ D TC E
Sbjct: 201 CNYGNGGCQHTC----DDTEQGPRCGCHIKFVLHTDGKTCIE 238
Score = 33.1 bits (72), Expect = 6.2
Identities = 18/56 (32%), Positives = 25/56 (44%), Gaps = 5/56 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC-SEPEEFLLFAQKN 919
++C NGGC C+ G Y C C + L+ + TC PEE + KN
Sbjct: 114 DECAEGNGGCQQSCVNMMG----SYECHCREGFFLSDNQHTCIQRPEEGMNCMNKN 165
Score = 33.1 bits (72), Expect = 6.2
Identities = 15/41 (36%), Positives = 20/41 (48%), Gaps = 3/41 (7%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYD 300
C+ NN GC H+C + + C+C G KL N C D
Sbjct: 281 CRLNNGGCDHICRNTVG--SFECSCKKGYKLLIN-ERNCQD 318
>AY358969-1|AAQ89328.1| 529|Homo sapiens HAI-1 protein.
Length = 529
Score = 41.9 bits (94), Expect = 0.013
Identities = 19/46 (41%), Positives = 22/46 (47%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAACAYGHTDQVNGIHPP 1193
FRC G CI + CD P C D SDEA D++ IH P
Sbjct: 340 FRCSNGCCIDSFLECDDTPNCPDASDEAACEKYTSGFDELQRIHFP 385
>AY296715-1|AAP44001.1| 529|Homo sapiens hepatocyte growth factor
activator inhibitor 1B protein.
Length = 529
Score = 41.9 bits (94), Expect = 0.013
Identities = 19/46 (41%), Positives = 22/46 (47%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAACAYGHTDQVNGIHPP 1193
FRC G CI + CD P C D SDEA D++ IH P
Sbjct: 340 FRCSNGCCIDSFLECDDTPNCPDASDEAACEKYTSGFDELQRIHFP 385
>AL163217-2|CAB90389.1| 904|Homo sapiens human enterokinase; EC
3.4.21.9. protein.
Length = 904
Score = 41.9 bits (94), Expect = 0.013
Identities = 18/45 (40%), Positives = 23/45 (51%)
Query: 1146 DAFRCDEGLCIAARFVCDGRPQCADGSDEAPAACAYGHTDQVNGI 1190
D F+C G C+ +CDG C DGSDEA + T NG+
Sbjct: 531 DHFQCKNGECVPLVNLCDGHLHCEDGSDEADCVRFFNGTTNNNGL 575
Score = 35.1 bits (77), Expect = 1.5
Identities = 16/32 (50%), Positives = 17/32 (53%), Gaps = 1/32 (3%)
Query: 1150 CDEGL-CIAARFVCDGRPQCADGSDEAPAACA 1180
C + L CI A CDG C DGSDE CA
Sbjct: 76 CTDALTCIKADLFCDGEVNCPDGSDEDNKMCA 107
>AF452494-1|AAN76808.1| 993|Homo sapiens CUB and EGF containing
protein protein.
Length = 993
Score = 41.9 bits (94), Expect = 0.013
Identities = 19/50 (38%), Positives = 26/50 (52%), Gaps = 1/50 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE-PEAFLVYSRKN 616
CA+ NGGC C N Y C C G L+ ++ TC++ PE + KN
Sbjct: 116 CAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKN 165
Score = 41.5 bits (93), Expect = 0.018
Identities = 16/36 (44%), Positives = 20/36 (55%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA +NGGC C + C CP+G L D+KTC
Sbjct: 240 CAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTC 275
Score = 40.3 bits (90), Expect = 0.041
Identities = 18/46 (39%), Positives = 27/46 (58%), Gaps = 5/46 (10%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPA-HYRLNKDNITCSEP 909
++C ++ GGC C+ TPG Y+C CPA RL+ + C+EP
Sbjct: 359 DECSINRGGCRFGCINTPG----SYQCTCPAGQGRLHWNGKDCTEP 400
Score = 39.5 bits (88), Expect = 0.071
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
C NGGC H C + CGC + L D KTC+E
Sbjct: 201 CNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIE 238
Score = 39.1 bits (87), Expect = 0.094
Identities = 17/45 (37%), Positives = 21/45 (46%), Gaps = 4/45 (8%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
C V+NGGC C D T C CP + L D TC + +E
Sbjct: 240 CAVNNGGCDSKC----HDAATGVHCTCPVGFMLQPDRKTCKDIDE 280
Score = 38.7 bits (86), Expect = 0.12
Identities = 13/36 (36%), Positives = 20/36 (55%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
C +NGGC H+C N + C C G +L +++ C
Sbjct: 281 CRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNC 316
Score = 38.3 bits (85), Expect = 0.16
Identities = 15/36 (41%), Positives = 19/36 (52%)
Query: 570 DDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
+DN GC H C N P +Y C C G L D C++
Sbjct: 77 EDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLD 112
Score = 38.3 bits (85), Expect = 0.16
Identities = 17/40 (42%), Positives = 20/40 (50%), Gaps = 1/40 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGL-ELTADKKTCVEP 606
C+ + GGC C N P Y C CP G L + K C EP
Sbjct: 361 CSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEP 400
Score = 37.9 bits (84), Expect = 0.22
Identities = 15/47 (31%), Positives = 26/47 (55%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
++C ++NGGC H+C T G + C+C Y+L + C + +E
Sbjct: 279 DECRLNNGGCDHICRNTVG----SFECSCKKGYKLLINERNCQDIDE 321
Score = 36.3 bits (80), Expect = 0.66
Identities = 15/37 (40%), Positives = 21/37 (56%), Gaps = 1/37 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYI-CGCPLGLELTADKKTC 603
C + N GC+H+C P I C C G ELT +++ C
Sbjct: 161 CMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDC 197
Score = 35.1 bits (77), Expect = 1.5
Identities = 16/42 (38%), Positives = 21/42 (50%), Gaps = 4/42 (9%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
DN GC H C+ PG +YRC C + L D C + +E
Sbjct: 78 DNAGCVHDCVNIPG----NYRCTCYDGFHLAHDGHNCLDVDE 115
Score = 34.7 bits (76), Expect = 2.0
Identities = 16/42 (38%), Positives = 18/42 (42%), Gaps = 4/42 (9%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSE 908
C NGGC H C D RC C + L+ D TC E
Sbjct: 201 CNYGNGGCQHTC----DDTEQGPRCGCHIKFVLHTDGKTCIE 238
Score = 33.1 bits (72), Expect = 6.2
Identities = 18/56 (32%), Positives = 25/56 (44%), Gaps = 5/56 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITC-SEPEEFLLFAQKN 919
++C NGGC C+ G Y C C + L+ + TC PEE + KN
Sbjct: 114 DECAEGNGGCQQSCVNMMG----SYECHCREGFFLSDNQHTCIQRPEEGMNCMNKN 165
Score = 33.1 bits (72), Expect = 6.2
Identities = 15/41 (36%), Positives = 20/41 (48%), Gaps = 3/41 (7%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYD 300
C+ NN GC H+C + + C+C G KL N C D
Sbjct: 281 CRLNNGGCDHICRNTVG--SFECSCKKGYKLLIN-ERNCQD 318
>AB000095-1|BAA25014.1| 513|Homo sapiens hepatocyte growth factor
activator inhibitor protein.
Length = 513
Score = 41.9 bits (94), Expect = 0.013
Identities = 19/46 (41%), Positives = 22/46 (47%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDEAPAACAYGHTDQVNGIHPP 1193
FRC G CI + CD P C D SDEA D++ IH P
Sbjct: 324 FRCSNGCCIDSFLECDDTPNCPDASDEAACEKYTSGFDELQRIHFP 369
>AK092062-1|BAC03798.1| 880|Homo sapiens protein ( Homo sapiens
cDNA FLJ34743 fis, clone MESAN2009019, moderately
similar to CEGP1 protein. ).
Length = 880
Score = 41.5 bits (93), Expect = 0.018
Identities = 16/36 (44%), Positives = 20/36 (55%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA +NGGC C + C CP+G L D+KTC
Sbjct: 127 CAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTC 162
Score = 40.3 bits (90), Expect = 0.041
Identities = 17/52 (32%), Positives = 25/52 (48%), Gaps = 4/52 (7%)
Query: 860 KSMGSNQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
+++ + C V+NGGC C D T C CP + L D TC + +E
Sbjct: 120 QAVSNETCAVNNGGCDSKC----HDAATGVHCTCPVGFMLQPDRKTCKDIDE 167
Score = 40.3 bits (90), Expect = 0.041
Identities = 18/46 (39%), Positives = 27/46 (58%), Gaps = 5/46 (10%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPA-HYRLNKDNITCSEP 909
++C ++ GGC C+ TPG Y+C CPA RL+ + C+EP
Sbjct: 246 DECSINRGGCRFGCINTPG----SYQCTCPAGQGRLHWNGKDCTEP 287
Score = 38.7 bits (86), Expect = 0.12
Identities = 13/36 (36%), Positives = 20/36 (55%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
C +NGGC H+C N + C C G +L +++ C
Sbjct: 168 CRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNC 203
Score = 38.3 bits (85), Expect = 0.16
Identities = 17/40 (42%), Positives = 20/40 (50%), Gaps = 1/40 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGL-ELTADKKTCVEP 606
C+ + GGC C N P Y C CP G L + K C EP
Sbjct: 248 CSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEP 287
Score = 37.9 bits (84), Expect = 0.22
Identities = 15/47 (31%), Positives = 26/47 (55%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
++C ++NGGC H+C T G + C+C Y+L + C + +E
Sbjct: 166 DECRLNNGGCDHICRNTVG----SFECSCKKGYKLLINERNCQDIDE 208
Score = 37.5 bits (83), Expect = 0.29
Identities = 15/37 (40%), Positives = 18/37 (48%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCV 604
C NGGC H C + CGC + L D KTC+
Sbjct: 72 CNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCI 108
Score = 36.3 bits (80), Expect = 0.66
Identities = 15/37 (40%), Positives = 21/37 (56%), Gaps = 1/37 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYI-CGCPLGLELTADKKTC 603
C + N GC+H+C P I C C G ELT +++ C
Sbjct: 32 CMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDC 68
Score = 33.9 bits (74), Expect = 3.5
Identities = 21/68 (30%), Positives = 24/68 (35%), Gaps = 6/68 (8%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGR--I 924
C NGGC H C D RC C + L+ D TC AV
Sbjct: 72 CNYGNGGCQHTC----DDTEQGPRCGCHIKFVLHTDGKTCIGERRLEQHIPTQAVSNETC 127
Query: 925 MVANGECN 932
V NG C+
Sbjct: 128 AVNNGGCD 135
Score = 33.1 bits (72), Expect = 6.2
Identities = 15/41 (36%), Positives = 20/41 (48%), Gaps = 3/41 (7%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYD 300
C+ NN GC H+C + + C+C G KL N C D
Sbjct: 168 CRLNNGGCDHICRNTVG--SFECSCKKGYKLLIN-ERNCQD 205
>BC126986-1|AAI26987.1| 393|Homo sapiens FLJ37440 protein protein.
Length = 393
Score = 40.7 bits (91), Expect = 0.031
Identities = 28/100 (28%), Positives = 40/100 (40%), Gaps = 8/100 (8%)
Query: 874 CSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVANG---E 930
C H C+ TPG YRC CP YR D +C + +E + G + G +
Sbjct: 194 CMHACVNTPGS----YRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQ 249
Query: 931 CNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVP 970
C P G NV ++ P + + DS R +P
Sbjct: 250 CVSPECP-EGSGNVSYVKTSPFQCERNPCPMDSRPCRHLP 288
Score = 37.5 bits (83), Expect = 0.29
Identities = 14/29 (48%), Positives = 15/29 (51%)
Query: 575 CSHLCFNRPDDYICGCPLGLELTADKKTC 603
C H C N P Y C CP G AD K+C
Sbjct: 194 CMHACVNTPGSYRCTCPGGYRTLADGKSC 222
>BC052263-1|AAH52263.2| 992|Homo sapiens signal peptide, CUB
domain, EGF-like 3 protein.
Length = 992
Score = 40.7 bits (91), Expect = 0.031
Identities = 17/41 (41%), Positives = 23/41 (56%), Gaps = 1/41 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE-PE 607
CA+ NGGC C N Y C C G L+ ++ TC++ PE
Sbjct: 116 CAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPE 156
Score = 40.7 bits (91), Expect = 0.031
Identities = 16/36 (44%), Positives = 20/36 (55%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
CA +NGGC C + C CP+G L D+KTC
Sbjct: 239 CAVNNGGCDSKCHDAAIGVHCTCPVGFMLQPDRKTC 274
Score = 40.3 bits (90), Expect = 0.041
Identities = 18/46 (39%), Positives = 27/46 (58%), Gaps = 5/46 (10%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPA-HYRLNKDNITCSEP 909
++C ++ GGC C+ TPG Y+C CPA RL+ + C+EP
Sbjct: 358 DECSINRGGCRFGCINTPG----SYQCTCPAGQGRLHWNGKDCTEP 399
Score = 39.5 bits (88), Expect = 0.071
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
C NGGC H C + CGC + L D KTC+E
Sbjct: 200 CNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIE 237
Score = 38.7 bits (86), Expect = 0.12
Identities = 13/36 (36%), Positives = 20/36 (55%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGLELTADKKTC 603
C +NGGC H+C N + C C G +L +++ C
Sbjct: 280 CRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNC 315
Score = 38.3 bits (85), Expect = 0.16
Identities = 15/36 (41%), Positives = 19/36 (52%)
Query: 570 DDNGGCSHLCFNRPDDYICGCPLGLELTADKKTCVE 605
+DN GC H C N P +Y C C G L D C++
Sbjct: 77 EDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLD 112
Score = 38.3 bits (85), Expect = 0.16
Identities = 17/40 (42%), Positives = 20/40 (50%), Gaps = 1/40 (2%)
Query: 568 CADDNGGCSHLCFNRPDDYICGCPLGL-ELTADKKTCVEP 606
C+ + GGC C N P Y C CP G L + K C EP
Sbjct: 360 CSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEP 399
Score = 37.9 bits (84), Expect = 0.22
Identities = 18/43 (41%), Positives = 24/43 (55%), Gaps = 2/43 (4%)
Query: 562 PLGWNPCADDNGGCSHLCFNRPDDYI-CGCPLGLELTADKKTC 603
P G N C + N GC+H+C P I C C G ELT +++ C
Sbjct: 155 PEGMN-CMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDC 196
Score = 37.9 bits (84), Expect = 0.22
Identities = 15/47 (31%), Positives = 26/47 (55%), Gaps = 4/47 (8%)
Query: 865 NQCGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
++C ++NGGC H+C T G + C+C Y+L + C + +E
Sbjct: 278 DECRLNNGGCDHICRNTVG----SFECSCKKGYKLLINERNCQDIDE 320
Score = 36.7 bits (81), Expect = 0.50
Identities = 16/45 (35%), Positives = 20/45 (44%), Gaps = 4/45 (8%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
C V+NGGC C D C CP + L D TC + +E
Sbjct: 239 CAVNNGGCDSKC----HDAAIGVHCTCPVGFMLQPDRKTCKDIDE 279
Score = 35.1 bits (77), Expect = 1.5
Identities = 16/42 (38%), Positives = 21/42 (50%), Gaps = 4/42 (9%)
Query: 870 DNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEE 911
DN GC H C+ PG +YRC C + L D C + +E
Sbjct: 78 DNAGCVHDCVNIPG----NYRCTCYDGFHLAHDGHNCLDVDE 115
Score = 34.7 bits (76), Expect = 2.0
Identities = 16/42 (38%), Positives = 18/42 (42%), Gaps = 4/42 (9%)
Query: 867 CGVDNGGCSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSE 908
C NGGC H C D RC C + L+ D TC E
Sbjct: 200 CNYGNGGCQHTC----DDTEQGPRCGCHIKFVLHTDGKTCIE 237
Score = 33.1 bits (72), Expect = 6.2
Identities = 15/41 (36%), Positives = 20/41 (48%), Gaps = 3/41 (7%)
Query: 260 CKKNNAGCSHLCLLSPDPPGYNCACPTGVKLRENSSTTCYD 300
C+ NN GC H+C + + C+C G KL N C D
Sbjct: 280 CRLNNGGCDHICRNTVG--SFECSCKKGYKLLIN-ERNCQD 317
>BC043141-1|AAH43141.1| 500|Homo sapiens low density lipoprotein
receptor-related protein 11 protein.
Length = 500
Score = 40.7 bits (91), Expect = 0.031
Identities = 16/27 (59%), Positives = 17/27 (62%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDE 1174
F CD+G CI CDG QC DGSDE
Sbjct: 315 FFCDDGCCIDITLACDGVQQCPDGSDE 341
>BC038242-1|AAH38242.1| 261|Homo sapiens Similar to RIKEN cDNA
1600015H20 gene protein.
Length = 261
Score = 40.7 bits (91), Expect = 0.031
Identities = 28/100 (28%), Positives = 40/100 (40%), Gaps = 8/100 (8%)
Query: 874 CSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVANG---E 930
C H C+ TPG YRC CP YR D +C + +E + G + G +
Sbjct: 62 CMHACVNTPGS----YRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQ 117
Query: 931 CNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVP 970
C P G NV ++ P + + DS R +P
Sbjct: 118 CVSPECP-EGSGNVSYVKTSPFQCERNPCPMDSRPCRHLP 156
Score = 37.5 bits (83), Expect = 0.29
Identities = 14/29 (48%), Positives = 15/29 (51%)
Query: 575 CSHLCFNRPDDYICGCPLGLELTADKKTC 603
C H C N P Y C CP G AD K+C
Sbjct: 62 CMHACVNTPGSYRCTCPGGYRTLADGKSC 90
>BC035784-1|AAH35784.1| 439|Homo sapiens hypothetical protein
FLJ37440 protein.
Length = 439
Score = 40.7 bits (91), Expect = 0.031
Identities = 28/100 (28%), Positives = 40/100 (40%), Gaps = 8/100 (8%)
Query: 874 CSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVANG---E 930
C H C+ TPG YRC CP YR D +C + +E + G + G +
Sbjct: 240 CMHACVNTPGS----YRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQ 295
Query: 931 CNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVP 970
C P G NV ++ P + + DS R +P
Sbjct: 296 CVSPECP-EGSGNVSYVKTSPFQCERNPCPMDSRPCRHLP 334
Score = 37.5 bits (83), Expect = 0.29
Identities = 14/29 (48%), Positives = 15/29 (51%)
Query: 575 CSHLCFNRPDDYICGCPLGLELTADKKTC 603
C H C N P Y C CP G AD K+C
Sbjct: 240 CMHACVNTPGSYRCTCPGGYRTLADGKSC 268
>AL355312-5|CAH72865.1| 500|Homo sapiens low density lipoprotein
receptor-related protein 11 protein.
Length = 500
Score = 40.7 bits (91), Expect = 0.031
Identities = 16/27 (59%), Positives = 17/27 (62%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDE 1174
F CD+G CI CDG QC DGSDE
Sbjct: 315 FFCDDGCCIDITLACDGVQQCPDGSDE 341
>AK094759-1|BAC04416.1| 439|Homo sapiens protein ( Homo sapiens
cDNA FLJ37440 fis, clone BRAWH2006405, weakly similar to
FIBULIN-1, ISOFORM C PRECURSOR. ).
Length = 439
Score = 40.7 bits (91), Expect = 0.031
Identities = 28/100 (28%), Positives = 40/100 (40%), Gaps = 8/100 (8%)
Query: 874 CSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVANG---E 930
C H C+ TPG YRC CP YR D +C + +E + G + G +
Sbjct: 240 CMHACVNTPGS----YRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQ 295
Query: 931 CNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVP 970
C P G NV ++ P + + DS R +P
Sbjct: 296 CVSPECP-EGSGNVSYVKTSPFQCERNPCPMDSRPCRHLP 334
Score = 37.5 bits (83), Expect = 0.29
Identities = 14/29 (48%), Positives = 15/29 (51%)
Query: 575 CSHLCFNRPDDYICGCPLGLELTADKKTC 603
C H C N P Y C CP G AD K+C
Sbjct: 240 CMHACVNTPGSYRCTCPGGYRTLADGKSC 268
>AK027641-1|BAB55257.1| 500|Homo sapiens protein ( Homo sapiens cDNA
FLJ14735 fis, clone NT2RP3002054. ).
Length = 500
Score = 40.7 bits (91), Expect = 0.031
Identities = 16/27 (59%), Positives = 17/27 (62%)
Query: 1148 FRCDEGLCIAARFVCDGRPQCADGSDE 1174
F CD+G CI CDG QC DGSDE
Sbjct: 315 FFCDDGCCIDITLACDGVQQCPDGSDE 341
>AC092645-2|AAY14854.1| 439|Homo sapiens unknown protein.
Length = 439
Score = 40.7 bits (91), Expect = 0.031
Identities = 28/100 (28%), Positives = 40/100 (40%), Gaps = 8/100 (8%)
Query: 874 CSHLCLPTPGDVRTDYRCACPAHYRLNKDNITCSEPEEFLLFAQKNAVGRIMVANG---E 930
C H C+ TPG YRC CP YR D +C + +E + G + G +
Sbjct: 240 CMHACVNTPGS----YRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQ 295
Query: 931 CNDAYIPLTGLKNVRAIEYDPVEKQLYWMDDDSHSIRRVP 970
C P G NV ++ P + + DS R +P
Sbjct: 296 CVSPECP-EGSGNVSYVKTSPFQCERNPCPMDSRPCRHLP 334
Score = 37.5 bits (83), Expect = 0.29
Identities = 14/29 (48%), Positives = 15/29 (51%)
Query: 575 CSHLCFNRPDDYICGCPLGLELTADKKTC 603
C H C N P Y C CP G AD K+C
Sbjct: 240 CMHACVNTPGSYRCTCPGGYRTLADGKSC 268
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.319 0.136 0.431
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 182,242,868
Number of Sequences: 224733
Number of extensions: 7932981
Number of successful extensions: 32076
Number of sequences better than 10.0: 458
Number of HSP's better than 10.0 without gapping: 401
Number of HSP's successfully gapped in prelim test: 57
Number of HSP's that attempted gapping in prelim test: 19370
Number of HSP's gapped (non-prelim): 6025
length of query: 1195
length of database: 73,234,838
effective HSP length: 98
effective length of query: 1097
effective length of database: 51,211,004
effective search space: 56178471388
effective search space used: 56178471388
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.8 bits)
S2: 71 (32.7 bits)
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