SilkBase IMG001 IMG002 IMG003 IMG005 IMG006 IMG007 IMG008 IMG009 kuwako IMG010 IMG011 IMG012

Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= BGIBMGA001035-TA|BGIBMGA001035-PA|IPR000644|CBS, IPR001093|IMP
dehydrogenase/GMP reductase, IPR005990|IMP dehydrogenase
         (512 letters)

Database: uniref50 
           1,657,284 sequences; 575,637,011 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_P20839 Cluster: Inosine-5'-monophosphate dehydrogenase ...   739   0.0  
UniRef50_P12268 Cluster: Inosine-5'-monophosphate dehydrogenase ...   725   0.0  
UniRef50_P21620 Cluster: Inosine-5'-monophosphate dehydrogenase;...   516   e-145
UniRef50_O96387 Cluster: Inosine-5'-monophosphate dehydrogenase;...   490   e-137
UniRef50_Q01F10 Cluster: IpdH inosine 5'-phosphate dehydrogenase...   481   e-134
UniRef50_Q4VRV8 Cluster: Inosine 5'monophosphate dehydrogenase; ...   481   e-134
UniRef50_Q4UCL4 Cluster: Inosine-5'-monophosphate dehydrogenase,...   472   e-131
UniRef50_P47996 Cluster: Inosine-5'-monophosphate dehydrogenase;...   434   e-120
UniRef50_A7QMJ8 Cluster: Chromosome chr19 scaffold_126, whole ge...   427   e-118
UniRef50_Q4SBU2 Cluster: Chromosome 19 SCAF14664, whole genome s...   419   e-115
UniRef50_A6R4D7 Cluster: Inosine-5'-monophosphate dehydrogenase;...   383   e-105
UniRef50_O67820 Cluster: Inosine-5'-monophosphate dehydrogenase;...   375   e-102
UniRef50_Q39F71 Cluster: IMP dehydrogenase; n=31; Proteobacteria...   357   4e-97
UniRef50_Q49729 Cluster: Inosine-5'-monophosphate dehydrogenase;...   346   7e-94
UniRef50_Q9RT87 Cluster: Inosine-5`-monophosphate dehydrogenase;...   331   2e-89
UniRef50_A7DPR0 Cluster: Inosine-5'-monophosphate dehydrogenase;...   331   2e-89
UniRef50_P0ADG9 Cluster: Inosine-5'-monophosphate dehydrogenase;...   325   1e-87
UniRef50_Q59011 Cluster: Inosine-5'-monophosphate dehydrogenase;...   313   8e-84
UniRef50_A6DTA2 Cluster: Inosine-5'-monophosphate dehydrogenase;...   305   1e-81
UniRef50_Q4QEB3 Cluster: Inosine-5'-monophosphate dehydrogenase;...   294   3e-78
UniRef50_Q4PBE7 Cluster: Putative uncharacterized protein; n=2; ...   281   2e-74
UniRef50_Q0DN24 Cluster: Os03g0780500 protein; n=7; Magnoliophyt...   265   2e-69
UniRef50_A7CYS7 Cluster: Malate dehydrogenase precursor; n=1; Op...   256   1e-66
UniRef50_Q8EW89 Cluster: Inosine-5'-monophosphate dehydrogenase;...   252   2e-65
UniRef50_P50097 Cluster: Inosine-5'-monophosphate dehydrogenase;...   240   7e-62
UniRef50_Q08MB8 Cluster: Inosine-5'-monophosphate dehydrogenase;...   223   9e-57
UniRef50_UPI00015B43E8 Cluster: PREDICTED: similar to GA14756-PA...   218   2e-55
UniRef50_P49058 Cluster: Inosine-5'-monophosphate dehydrogenase;...   205   2e-51
UniRef50_Q74LZ0 Cluster: Inosine-5-monophosphate dehydrogenase; ...   189   1e-46
UniRef50_P65172 Cluster: Uncharacterized oxidoreductase Rv1843c/...   170   9e-41
UniRef50_A3H9U2 Cluster: IMP dehydrogenase; n=1; Caldivirga maqu...   167   5e-40
UniRef50_Q6MM64 Cluster: Inosine-5-monophosphate dehydrogenase; ...   164   4e-39
UniRef50_A1RZ33 Cluster: GMP reductase; n=1; Thermofilum pendens...   151   3e-35
UniRef50_Q5V6J1 Cluster: Inosine-5'-monophosphate dehydrogenase;...   149   2e-34
UniRef50_Q1IAJ4 Cluster: Putative inosine-5'-monophosphate dehyd...   142   2e-32
UniRef50_Q2JC64 Cluster: GMP reductase; n=2; Bacteria|Rep: GMP r...   140   8e-32
UniRef50_Q9P2T1 Cluster: GMP reductase 2; n=169; cellular organi...   124   6e-27
UniRef50_P60565 Cluster: GMP reductase; n=111; root|Rep: GMP red...   121   5e-26
UniRef50_Q9YBU2 Cluster: Inosine-5'-monophosphate dehydrogenase;...   119   2e-25
UniRef50_Q5ZRN7 Cluster: Inosine 5'-monophosphate dehydrogenase;...   116   1e-24
UniRef50_A4GHK1 Cluster: Guanosine monophosphate reductase; n=1;...   105   4e-21
UniRef50_Q7NTY1 Cluster: GMP reductase; n=1; Chromobacterium vio...   101   3e-20
UniRef50_Q4S0S1 Cluster: Chromosome undetermined SCAF14779, whol...    99   3e-19
UniRef50_Q4X988 Cluster: Putative uncharacterized protein; n=6; ...    97   7e-19
UniRef50_Q4S0S8 Cluster: Chromosome undetermined SCAF14779, whol...    97   1e-18
UniRef50_Q0PQW0 Cluster: Putative inosine-5'-monophosphate dehyd...    95   4e-18
UniRef50_Q4UGU3 Cluster: Gmp reductase, putative; n=3; Piroplasm...    93   2e-17
UniRef50_Q2JL45 Cluster: IMP dehydrogenase family protein; n=43;...    84   7e-15
UniRef50_Q5RGU9 Cluster: Novel protein similar to vertebrate IMP...    77   8e-13
UniRef50_Q7VQ71 Cluster: GuaB gene for inosine 5-monophosphase d...    74   1e-11
UniRef50_Q4T162 Cluster: Chromosome 21 SCAF10714, whole genome s...    71   7e-11
UniRef50_Q8EUA0 Cluster: Guanosine 5'-monophosphate oxidoreducta...    71   7e-11
UniRef50_A1SMV5 Cluster: IMP dehydrogenase family protein; n=7; ...    70   2e-10
UniRef50_Q03YG3 Cluster: IMP dehydrogenase/GMP reductase; n=1; L...    69   3e-10
UniRef50_P74477 Cluster: Chloride channel protein; n=3; Chroococ...    66   3e-09
UniRef50_A6Y440 Cluster: GMP reductase; n=1; Vibrio cholerae RC3...    64   6e-09
UniRef50_P65170 Cluster: Uncharacterized oxidoreductase Rv3410c/...    64   6e-09
UniRef50_Q57647 Cluster: Uncharacterized protein MJ0188; n=6; Me...    63   1e-08
UniRef50_Q0S3A9 Cluster: Possible IMP dehydrogenase/GMP reductas...    63   2e-08
UniRef50_O27343 Cluster: Inosine-5'-monophosphate dehydrogenase ...    62   3e-08
UniRef50_O29009 Cluster: Inosine monophosphate dehydrogenase, pu...    57   1e-06
UniRef50_O28857 Cluster: Chloride channel, putative; n=2; Euryar...    56   2e-06
UniRef50_Q191T3 Cluster: Polynucleotide adenylyltransferase regi...    56   3e-06
UniRef50_O26907 Cluster: Sporulation protein IVFB related protei...    56   3e-06
UniRef50_Q2NEF3 Cluster: Putative uncharacterized protein; n=1; ...    54   7e-06
UniRef50_Q97F91 Cluster: Proline/glycine betaine ABC-type transp...    54   1e-05
UniRef50_Q02B15 Cluster: Putative signal-transduction protein wi...    54   1e-05
UniRef50_Q64C69 Cluster: Chloride channel; n=1; uncultured archa...    54   1e-05
UniRef50_O27290 Cluster: Inosine-5'-monophosphate dehydrogenase ...    53   2e-05
UniRef50_Q4TGB6 Cluster: Chromosome undetermined SCAF3807, whole...    53   2e-05
UniRef50_Q9HRK9 Cluster: Inosine-5'-monophosphate dehydrogenase;...    52   4e-05
UniRef50_Q2ACT2 Cluster: CBS:Phosphoesterase, RecJ-like:Polynucl...    52   5e-05
UniRef50_Q3AAR6 Cluster: PolyA polymerase family protein; n=1; C...    51   6e-05
UniRef50_A7HLG0 Cluster: Polynucleotide adenylyltransferase regi...    51   8e-05
UniRef50_A1HSL2 Cluster: Putative signal transduction protein wi...    51   8e-05
UniRef50_A6TR64 Cluster: Polynucleotide adenylyltransferase regi...    50   1e-04
UniRef50_A4J3L2 Cluster: Polynucleotide adenylyltransferase regi...    50   1e-04
UniRef50_Q31MV1 Cluster: CBS; n=3; Synechococcus elongatus|Rep: ...    50   1e-04
UniRef50_Q58629 Cluster: Uncharacterized protein MJ1232; n=6; Me...    50   1e-04
UniRef50_A7HD42 Cluster: Putative signal transduction protein wi...    50   2e-04
UniRef50_Q3E1R1 Cluster: CBS; n=3; Bacteria|Rep: CBS - Chlorofle...    49   3e-04
UniRef50_Q2NBF2 Cluster: CBS; n=3; Bacteria|Rep: CBS - Erythroba...    49   3e-04
UniRef50_Q898U3 Cluster: Inosine-5-monophosphate dehydrogenase r...    49   3e-04
UniRef50_Q8DLH3 Cluster: Tll0519 protein; n=4; Cyanobacteria|Rep...    48   4e-04
UniRef50_O66749 Cluster: Putative uncharacterized protein; n=1; ...    48   4e-04
UniRef50_A7RLX0 Cluster: Predicted protein; n=1; Nematostella ve...    48   4e-04
UniRef50_UPI00015BB20C Cluster: putative signal transduction pro...    48   8e-04
UniRef50_Q2JHW1 Cluster: PolyA polymerase family protein; n=3; S...    48   8e-04
UniRef50_Q8TWX4 Cluster: Prdicted regulatory protein consisting ...    48   8e-04
UniRef50_Q8R911 Cluster: CBS domains; n=3; Thermoanaerobacter|Re...    47   0.001
UniRef50_Q6Q303 Cluster: IMP dehydrogenase; n=1; Synechococcus s...    47   0.001
UniRef50_A0LGS9 Cluster: CBS domain containing membrane protein;...    47   0.001
UniRef50_Q96YR0 Cluster: Putative uncharacterized protein ST2113...    47   0.001
UniRef50_Q9X175 Cluster: Inosine-5-monophosphate dehydrogenase-r...    46   0.002
UniRef50_A5IN38 Cluster: CBS domain containing protein; n=2; The...    46   0.002
UniRef50_Q2ACR8 Cluster: CBS; n=1; Halothermothrix orenii H 168|...    46   0.002
UniRef50_A4M812 Cluster: Polynucleotide adenylyltransferase regi...    46   0.002
UniRef50_O29915 Cluster: Putative uncharacterized protein; n=1; ...    46   0.002
UniRef50_Q7NVZ6 Cluster: Putative uncharacterized protein; n=3; ...    46   0.003
UniRef50_O26229 Cluster: Inosine-5'-monophosphate dehydrogenase ...    46   0.003
UniRef50_A3CWH1 Cluster: CBS domain containing protein; n=1; Met...    46   0.003
UniRef50_A7HCW1 Cluster: Putative signal-transduction protein wi...    45   0.004
UniRef50_A2ST08 Cluster: CBS domain containing protein; n=2; Met...    45   0.004
UniRef50_A6SYJ5 Cluster: Inosine-5'-monophosphate dehydrogenase;...    45   0.006
UniRef50_A5WFG6 Cluster: FMN-dependent alpha-hydroxy acid dehydr...    45   0.006
UniRef50_A1VAU2 Cluster: CBS domain containing protein; n=3; Des...    45   0.006
UniRef50_A7D0I7 Cluster: Peptidase M50; n=4; Halobacteriaceae|Re...    45   0.006
UniRef50_A0B5X6 Cluster: Putative signal-transduction protein wi...    45   0.006
UniRef50_Q67L31 Cluster: Glycine betaine/carnitine/choline ABC t...    44   0.007
UniRef50_Q3AFS5 Cluster: CBS/GGDEF domain protein; n=1; Carboxyd...    44   0.007
UniRef50_A5N386 Cluster: Putative uncharacterized protein; n=1; ...    44   0.007
UniRef50_A2SQ80 Cluster: CBS domain containing protein; n=4; Met...    44   0.007
UniRef50_A2BJ31 Cluster: Predicted transcriptional regulator; n=...    44   0.007
UniRef50_Q9WZH4 Cluster: TRNA nucleotidyl transferase-related pr...    44   0.010
UniRef50_A1CVD5 Cluster: 2-nitropropane dioxygenase family oxido...    44   0.010
UniRef50_A2BLX1 Cluster: Conserved archaeal protein; n=1; Hypert...    44   0.010
UniRef50_Q67NF3 Cluster: Putative poly A polymerase; n=1; Symbio...    44   0.013
UniRef50_A5V6U0 Cluster: FMN-dependent alpha-hydroxy acid dehydr...    44   0.013
UniRef50_A1HPJ0 Cluster: Sigma54 specific transcriptional regula...    44   0.013
UniRef50_Q0W4Y8 Cluster: Putative uncharacterized protein; n=1; ...    44   0.013
UniRef50_Q835K5 Cluster: CBS domain protein; n=6; Bacilli|Rep: C...    43   0.017
UniRef50_Q1IKU8 Cluster: 2-nitropropane dioxygenase, NPD; n=2; B...    43   0.017
UniRef50_A5D444 Cluster: Putative uncharacterized protein; n=1; ...    43   0.017
UniRef50_Q2H129 Cluster: Putative uncharacterized protein; n=1; ...    43   0.017
UniRef50_Q8TX12 Cluster: CBS-domain-containing protein; n=3; Eur...    43   0.017
UniRef50_Q57976 Cluster: Methylated protein MJ0556; n=2; Methano...    43   0.017
UniRef50_Q97M06 Cluster: Deoxyphosphogluconate aldolase; n=1; Cl...    43   0.022
UniRef50_Q5WEY2 Cluster: Putative uncharacterized protein; n=1; ...    43   0.022
UniRef50_Q3JCC7 Cluster: Peptidase M50; n=1; Nitrosococcus ocean...    43   0.022
UniRef50_Q0SD75 Cluster: Possible nitropropane dioxygenase; n=1;...    43   0.022
UniRef50_Q0SD94 Cluster: Possible 2-nitropropane dioxygenase; n=...    43   0.022
UniRef50_A4J1P0 Cluster: Putative signal-transduction protein wi...    43   0.022
UniRef50_Q2FT94 Cluster: Putative signal-transduction protein wi...    43   0.022
UniRef50_Q1D9V2 Cluster: CBS domain protein; n=1; Myxococcus xan...    42   0.029
UniRef50_A7HHL2 Cluster: Putative CBS domain and cyclic nucleoti...    42   0.039
UniRef50_A6GTG2 Cluster: Putative uncharacterized protein; n=1; ...    42   0.039
UniRef50_A0TVV5 Cluster: 2-nitropropane dioxygenase, NPD; n=1; B...    42   0.039
UniRef50_A0LL65 Cluster: Peptidase M50; n=2; Syntrophobacter fum...    42   0.039
UniRef50_Q8R7I7 Cluster: Putative N-acetylmannosamine-6-phosphat...    42   0.039
UniRef50_Q3ZXE7 Cluster: Metallopeptidase, M50 family; n=3; Deha...    42   0.051
UniRef50_Q3DF47 Cluster: AcuB family protein; n=27; Streptococcu...    42   0.051
UniRef50_Q24MB2 Cluster: Putative uncharacterized protein; n=2; ...    42   0.051
UniRef50_Q0PQV9 Cluster: Putative inosine-5'-monophosphate dehyd...    42   0.051
UniRef50_Q9YFL7 Cluster: Putative uncharacterized protein; n=1; ...    42   0.051
UniRef50_Q8PYN6 Cluster: Conserved protein; n=6; Euryarchaeota|R...    42   0.051
UniRef50_Q8PUG3 Cluster: Conserved protein; n=8; Euryarchaeota|R...    42   0.051
UniRef50_O27616 Cluster: Inosine-5'-monophosphate dehydrogenase ...    42   0.051
UniRef50_P54606 Cluster: Uncharacterized protein yhcV; n=6; Baci...    42   0.051
UniRef50_Q5LSF9 Cluster: Nucleotidyltransferase/CBS/cyclic nucle...    41   0.068
UniRef50_Q8VKG1 Cluster: FMN-dependent alpha-hydroxy acid dehydr...    41   0.068
UniRef50_Q1AXH4 Cluster: CBS domain containing membrane protein;...    41   0.068
UniRef50_A5UX62 Cluster: Polynucleotide adenylyltransferase regi...    41   0.068
UniRef50_A3W676 Cluster: Nucleotidyltransferase/CBS/cyclic nucle...    41   0.068
UniRef50_A0QGC0 Cluster: Oxidoreductase, 2-nitropropane dioxygen...    41   0.068
UniRef50_A0PYB8 Cluster: CBS domain containing protein; n=3; Clo...    41   0.068
UniRef50_A0G4J4 Cluster: 2-nitropropane dioxygenase, NPD; n=1; B...    41   0.068
UniRef50_O86223 Cluster: Putative uncharacterized protein HI0221...    41   0.068
UniRef50_Q3ZYM9 Cluster: 1-(5-phosphoribosyl)-5-[(5-phosphoribos...    41   0.068
UniRef50_Q98QF8 Cluster: MG2+ TRANSPORT PROTEIN; n=1; Mycoplasma...    41   0.090
UniRef50_Q74HC1 Cluster: Glycolate oxidase; n=8; Lactobacillacea...    41   0.090
UniRef50_Q9LUF7 Cluster: Emb|CAB86899.1; n=6; Magnoliophyta|Rep:...    41   0.090
UniRef50_Q3IUS4 Cluster: Probable metalloprotease/ CBS domain pr...    41   0.090
UniRef50_A2BJY0 Cluster: Voltage-gated chloride channel protein;...    41   0.090
UniRef50_Q58069 Cluster: Uncharacterized protein MJ0653; n=1; Me...    41   0.090
UniRef50_Q9RVN7 Cluster: Acetoin utilization protein, putative; ...    40   0.12 
UniRef50_A4AAP3 Cluster: Acetoin utilization protein AcuB; n=1; ...    40   0.12 
UniRef50_A3SFF5 Cluster: FMN-dependent alpha-hydroxy acid dehydr...    40   0.12 
UniRef50_Q3SB86 Cluster: CBS domain protein; n=1; uncultured eur...    40   0.12 
UniRef50_A7IAI3 Cluster: Putative signal transduction protein wi...    40   0.12 
UniRef50_Q15XE0 Cluster: 2-nitropropane dioxygenase, NPD; n=9; P...    40   0.16 
UniRef50_A6GD90 Cluster: Acetoin utilization protein AcuB; n=1; ...    40   0.16 
UniRef50_A6CN21 Cluster: CBS domain protein; n=1; Bacillus sp. S...    40   0.16 
UniRef50_Q01N18 Cluster: OSIGBa0147B06.5 protein; n=3; Oryza sat...    40   0.16 
UniRef50_A7DSJ1 Cluster: Putative signal-transduction protein wi...    40   0.16 
UniRef50_Q9CG58 Cluster: L-lactate oxidase; n=6; Bacteria|Rep: L...    40   0.21 
UniRef50_Q62DY2 Cluster: FMN-dependent dehydrogenase; n=17; Prot...    40   0.21 
UniRef50_Q2CIM8 Cluster: Alcohol dehydrogenase, zinc containing;...    40   0.21 
UniRef50_Q1AXT4 Cluster: Inorganic diphosphatase; n=1; Rubrobact...    40   0.21 
UniRef50_A5URS2 Cluster: CBS domain containing protein; n=2; Ros...    40   0.21 
UniRef50_Q4PDX7 Cluster: Putative uncharacterized protein; n=1; ...    40   0.21 
UniRef50_Q8TZ50 Cluster: CBS-domain-containing protein; n=1; Met...    40   0.21 
UniRef50_O13965 Cluster: Meiotically up-regulated gene 70 protei...    40   0.21 
UniRef50_Q7U851 Cluster: 1-(5-phosphoribosyl)-5-[(5-phosphoribos...    40   0.21 
UniRef50_Q4US80 Cluster: 2-nitropropane dioxygenase; n=9; Proteo...    39   0.27 
UniRef50_Q180W2 Cluster: Putative uncharacterized protein; n=1; ...    39   0.27 
UniRef50_A6QB31 Cluster: 2-nitropropane dioxygenase; n=29; Bacte...    39   0.27 
UniRef50_A3PVW7 Cluster: 2-nitropropane dioxygenase, NPD; n=8; C...    39   0.27 
UniRef50_A1ZUR2 Cluster: CBS domain protein; n=2; Bacteroidetes|...    39   0.27 
UniRef50_Q54H97 Cluster: Putative acetoin dehydrogenase; n=1; Di...    39   0.27 
UniRef50_Q2RGX5 Cluster: Ferredoxin-dependent glutamate synthase...    39   0.36 
UniRef50_Q08PS9 Cluster: CBS; n=1; Stigmatella aurantiaca DW4/3-...    39   0.36 
UniRef50_A3M1P1 Cluster: Magnesium and cobalt efflux protein; n=...    39   0.36 
UniRef50_A0HCZ3 Cluster: FMN-dependent alpha-hydroxy acid dehydr...    39   0.36 
UniRef50_Q97U50 Cluster: Putative uncharacterized protein; n=1; ...    39   0.36 
UniRef50_Q8TXY3 Cluster: CBS domain-containing protein; n=1; Met...    39   0.36 
UniRef50_O26296 Cluster: Glutamate synthase (NADPH), alpha subun...    39   0.36 
UniRef50_A5UM30 Cluster: IMP dehydrogenase related protein; n=1;...    39   0.36 
UniRef50_A0B5X2 Cluster: CBS domain containing membrane protein;...    39   0.36 
UniRef50_Q57837 Cluster: Putative zinc metalloprotease MJ0392; n...    39   0.36 
UniRef50_Q9KGA2 Cluster: BH0210 protein; n=7; Bacillaceae|Rep: B...    38   0.48 
UniRef50_Q8F624 Cluster: L-lactate dehydrogenase; n=4; Leptospir...    38   0.48 
UniRef50_Q6AJC1 Cluster: Related to acetoin utilization protein;...    38   0.48 
UniRef50_Q5QUI2 Cluster: Signaling protein with a cAMP-binding, ...    38   0.48 
UniRef50_P74081 Cluster: PolyA polymerase; n=4; Cyanobacteria|Re...    38   0.48 
UniRef50_Q3T556 Cluster: CBS domain-like protein; n=5; Bacteria|...    38   0.48 
UniRef50_Q11EL1 Cluster: CBS domain containing protein; n=13; Pr...    38   0.48 
UniRef50_A6LV86 Cluster: Sigma54 specific transcriptional regula...    38   0.48 
UniRef50_A5URS3 Cluster: CBS domain containing protein; n=4; Chl...    38   0.48 
UniRef50_A4M3K4 Cluster: CBS domain containing membrane protein;...    38   0.48 
UniRef50_A3ZL92 Cluster: Putative uncharacterized protein; n=1; ...    38   0.48 
UniRef50_O27702 Cluster: Glutamate synthase (NADPH), alpha subun...    38   0.48 
UniRef50_A3CWH3 Cluster: CBS domain containing protein; n=1; Met...    38   0.48 
UniRef50_Q97EU8 Cluster: CBS domain containing protein; n=1; Clo...    38   0.63 
UniRef50_Q3J9M3 Cluster: CBS domain containing protein; n=1; Nit...    38   0.63 
UniRef50_Q8GA65 Cluster: Putative FMN-dependent dehydrogenase; n...    38   0.63 
UniRef50_Q3RE81 Cluster: 2-nitropropane dioxygenase, NPD precurs...    38   0.63 
UniRef50_A4WYL0 Cluster: Putative uncharacterized protein; n=1; ...    38   0.63 
UniRef50_A4M6L8 Cluster: 2-nitropropane dioxygenase, NPD; n=2; B...    38   0.63 
UniRef50_A1IEP7 Cluster: Putative uncharacterized protein; n=1; ...    38   0.63 
UniRef50_A1I7E2 Cluster: 2-nitropropane dioxygenase, NPD; n=1; C...    38   0.63 
UniRef50_O29411 Cluster: Inosine monophosphate dehydrogenase; n=...    38   0.63 
UniRef50_Q58410 Cluster: Uncharacterized protein MJ1004; n=6; Me...    38   0.63 
UniRef50_A3CTR9 Cluster: 1-(5-phosphoribosyl)-5-[(5-phosphoribos...    38   0.63 
UniRef50_UPI00015BAEC4 Cluster: putative signal-transduction pro...    38   0.84 
UniRef50_Q9K9P0 Cluster: BH2605 protein; n=6; Bacteria|Rep: BH26...    38   0.84 
UniRef50_Q3WH73 Cluster: CBS domain; n=2; Frankia|Rep: CBS domai...    38   0.84 
UniRef50_Q122S0 Cluster: 2-nitropropane dioxygenase, NPD; n=68; ...    38   0.84 
UniRef50_Q0VMM0 Cluster: 2-nitropropane dioxygenase, putative; n...    38   0.84 
UniRef50_Q0AHF1 Cluster: Putative signal-transduction protein wi...    38   0.84 
UniRef50_A1SM43 Cluster: 2-nitropropane dioxygenase, NPD; n=1; N...    38   0.84 
UniRef50_Q6C9A7 Cluster: Similar to sp|Q9WU19 Mus musculus Hydro...    38   0.84 
UniRef50_Q6LXU6 Cluster: Putative uncharacterized protein; n=5; ...    38   0.84 
UniRef50_Q4JBX5 Cluster: Conserved CBS domain protein; n=2; Sulf...    38   0.84 
UniRef50_Q4JAS3 Cluster: Protein pcrB homolog; n=4; Sulfolobacea...    38   0.84 
UniRef50_A4FVH7 Cluster: Hao1 protein; n=9; Deuterostomia|Rep: H...    37   1.1  
UniRef50_Q9KDK7 Cluster: BH1205 protein; n=2; Bacillus|Rep: BH12...    37   1.1  
UniRef50_Q98DX5 Cluster: Cysteine synthase; n=42; Bacteria|Rep: ...    37   1.1  
UniRef50_Q98DF1 Cluster: Glycolate oxidase (S)-2-hydroxy-acid ox...    37   1.1  
UniRef50_Q8NQY4 Cluster: Predicted signal-transduction protein c...    37   1.1  
UniRef50_Q8DHZ1 Cluster: CBS domain protein; n=1; Synechococcus ...    37   1.1  
UniRef50_Q8CXK9 Cluster: Glutamate synthase (NADPH) large (Alpha...    37   1.1  
UniRef50_Q5LKQ6 Cluster: Oxidoreductase, 2-nitropropane dioxygen...    37   1.1  
UniRef50_Q3A5H4 Cluster: Putative Fe-S oxidoreductase; n=1; Pelo...    37   1.1  
UniRef50_Q21UP4 Cluster: Putative signal-transduction protein wi...    37   1.1  
UniRef50_Q1Q2I4 Cluster: Putative uncharacterized protein; n=1; ...    37   1.1  
UniRef50_Q1LK44 Cluster: 2-nitropropane dioxygenase, NPD; n=2; B...    37   1.1  
UniRef50_A6CKR1 Cluster: Putative uncharacterized protein; n=1; ...    37   1.1  
UniRef50_A5UUL3 Cluster: Thiamine-phosphate pyrophosphorylase; n...    37   1.1  
UniRef50_O27292 Cluster: Inosine-5'-monophosphate dehydrogenase ...    37   1.1  
UniRef50_P61411 Cluster: Putative thiamine-phosphate pyrophospho...    37   1.1  
UniRef50_Q3AYT2 Cluster: 1-(5-phosphoribosyl)-5-[(5-phosphoribos...    37   1.1  
UniRef50_O87392 Cluster: Glutamate synthase large subunit-like p...    37   1.1  
UniRef50_UPI0000E45D53 Cluster: PREDICTED: similar to Hao1 prote...    37   1.5  
UniRef50_Q89DV5 Cluster: Blr7332 protein; n=2; Proteobacteria|Re...    37   1.5  
UniRef50_Q18QE4 Cluster: Ferredoxin-dependent glutamate synthase...    37   1.5  
UniRef50_Q0RJ56 Cluster: Putative Glycolate oxidase; n=1; Franki...    37   1.5  
UniRef50_A0YE28 Cluster: CBS domain containing membrane protein;...    37   1.5  
UniRef50_A0WCB8 Cluster: Twin-arginine translocation pathway sig...    37   1.5  
UniRef50_Q3IUC7 Cluster: CBS domain protein 2; n=4; Halobacteria...    37   1.5  
UniRef50_Q8YSG5 Cluster: Sensor protein; n=3; Cyanobacteria|Rep:...    36   1.9  
UniRef50_Q7MZC1 Cluster: Similar to lactate oxidase; n=1; Photor...    36   1.9  
UniRef50_Q6ASD5 Cluster: Related to poly(A) polymerase; n=1; Des...    36   1.9  
UniRef50_Q5WGH8 Cluster: Proline/glycine betaine ABC transporter...    36   1.9  
UniRef50_Q5HNK0 Cluster: CBS domain protein; n=16; Staphylococcu...    36   1.9  
UniRef50_Q3SPZ7 Cluster: Histidine biosynthesis; n=1; Nitrobacte...    36   1.9  
UniRef50_Q2RL38 Cluster: Diguanylate cyclase; n=2; Clostridia|Re...    36   1.9  
UniRef50_Q2IQL5 Cluster: Putative transcriptional regulator, XRE...    36   1.9  
UniRef50_Q1CVT6 Cluster: CBS domain protein; n=1; Myxococcus xan...    36   1.9  
UniRef50_A5VE75 Cluster: FMN-dependent alpha-hydroxy acid dehydr...    36   1.9  
UniRef50_A1W7G3 Cluster: CBS domain containing protein; n=3; Com...    36   1.9  
UniRef50_A0NXC3 Cluster: 2-nitropropane dioxygenase, NPD; n=1; S...    36   1.9  
UniRef50_Q01E22 Cluster: COG2070: Dioxygenases related to 2-nitr...    36   1.9  
UniRef50_O27073 Cluster: Inosine-5'-monophosphate dehydrogenase ...    36   1.9  
UniRef50_Q0W6W1 Cluster: Predicted metalloprotease; n=1; uncultu...    36   1.9  
UniRef50_Q0W3K0 Cluster: Conserved hypothetical CBS domain prote...    36   1.9  
UniRef50_Q0W3J9 Cluster: Conserved hypothetical CBS domain prote...    36   1.9  
UniRef50_P50100 Cluster: Uncharacterized protein MK0525; n=1; Me...    36   1.9  
UniRef50_Q58799 Cluster: Uncharacterized protein MJ1404; n=7; Ar...    36   1.9  
UniRef50_P20932 Cluster: (S)-mandelate dehydrogenase (EC 1.1.99....    36   1.9  
UniRef50_UPI000023D501 Cluster: hypothetical protein FG00145.1; ...    36   2.6  
UniRef50_Q7V9S3 Cluster: L-lactate dehydrogenase (FMN-dependent)...    36   2.6  
UniRef50_Q6ML62 Cluster: 2-nitropropane dioxygenase; n=1; Bdello...    36   2.6  
UniRef50_Q39UG3 Cluster: CBS domain containing membrane protein;...    36   2.6  
UniRef50_Q41GS5 Cluster: CBS; n=1; Exiguobacterium sibiricum 255...    36   2.6  
UniRef50_Q1Q3V8 Cluster: Putative uncharacterized protein; n=1; ...    36   2.6  
UniRef50_Q1AXV7 Cluster: Putative signal transduction protein wi...    36   2.6  
UniRef50_A0LCY3 Cluster: Putative signal-transduction protein wi...    36   2.6  
UniRef50_A0HLX4 Cluster: 2-nitropropane dioxygenase, NPD; n=2; C...    36   2.6  
UniRef50_Q97AJ9 Cluster: Inosine-5-monophosphate dehydrogenase; ...    36   2.6  
UniRef50_O28109 Cluster: 2-nitropropane dioxygenase; n=1; Archae...    36   2.6  
UniRef50_A3CWH2 Cluster: CBS domain containing protein; n=2; Met...    36   2.6  
UniRef50_P35500-9 Cluster: Isoform exond of P35500 ; n=24; Arthr...    36   3.4  
UniRef50_Q8DKD5 Cluster: Tlr0924 protein; n=1; Synechococcus elo...    36   3.4  
UniRef50_Q89K26 Cluster: Bll5092 protein; n=3; Bradyrhizobium|Re...    36   3.4  
UniRef50_Q6N8G2 Cluster: Possible 2-nitropropane dioxygenase; n=...    36   3.4  
UniRef50_Q6MJ98 Cluster: Putative inosine-5'-monophosphate dehyd...    36   3.4  
UniRef50_Q6AN54 Cluster: Related to two-component system respons...    36   3.4  
UniRef50_Q2SLE2 Cluster: L-lactate dehydrogenase (FMN-dependent)...    36   3.4  
UniRef50_Q2RZU3 Cluster: CBS domain pair protein; n=2; Salinibac...    36   3.4  
UniRef50_Q6SH70 Cluster: Oxidoreductase, 2-nitropropane dioxygen...    36   3.4  
UniRef50_Q4AIJ6 Cluster: Geranylgeranylglyceryl phosphate syntha...    36   3.4  
UniRef50_Q3W684 Cluster: FMN-dependent alpha-hydroxy acid dehydr...    36   3.4  
UniRef50_Q1D9J4 Cluster: Tetratricopeptide repeat protein; n=1; ...    36   3.4  
UniRef50_Q18SL5 Cluster: Ferredoxin-dependent glutamate synthase...    36   3.4  
UniRef50_Q0K474 Cluster: 2-Nitropropane dioxygenase; n=3; Cupria...    36   3.4  
UniRef50_Q0AX27 Cluster: PolyA polymerase family protein precurs...    36   3.4  
UniRef50_Q01QB6 Cluster: FMN-dependent alpha-hydroxy acid dehydr...    36   3.4  
UniRef50_A7AGI1 Cluster: Putative uncharacterized protein; n=1; ...    36   3.4  
UniRef50_A6SYD0 Cluster: Signal transduction protein; n=1; Janth...    36   3.4  
UniRef50_A5VE54 Cluster: L-lactate dehydrogenase; n=1; Sphingomo...    36   3.4  
UniRef50_Q2V3V9 Cluster: Uncharacterized protein At3g14420.3; n=...    36   3.4  
UniRef50_Q86H81 Cluster: Similar to Oceanobacillus iheyensis. 2-...    36   3.4  
UniRef50_Q4FYS1 Cluster: Cysteine peptidase, Clan CA, family C2,...    36   3.4  
UniRef50_Q2GMR8 Cluster: Putative uncharacterized protein; n=1; ...    36   3.4  
UniRef50_Q0CRW0 Cluster: Putative uncharacterized protein; n=1; ...    36   3.4  
UniRef50_P95951 Cluster: Orf c04012 protein; n=4; Sulfolobaceae|...    36   3.4  
UniRef50_A3CTZ5 Cluster: PAS/PAC sensor signal transduction hist...    36   3.4  
UniRef50_A2BLX4 Cluster: Conserved archaeal protein; n=1; Hypert...    36   3.4  
UniRef50_P35500 Cluster: Sodium channel protein para; n=55; Arth...    36   3.4  
UniRef50_Q8DGQ5 Cluster: Putative N-acetylmannosamine-6-phosphat...    36   3.4  
UniRef50_Q9LRS0 Cluster: Probable peroxisomal (S)-2-hydroxy-acid...    36   3.4  
UniRef50_UPI0000E4606B Cluster: PREDICTED: similar to MGC108441 ...    35   4.5  
UniRef50_UPI00006D0109 Cluster: hypothetical protein TTHERM_0082...    35   4.5  
UniRef50_Q8F0T1 Cluster: Putative uncharacterized protein; n=4; ...    35   4.5  
UniRef50_Q89LA1 Cluster: Blr4646 protein; n=3; Bradyrhizobiaceae...    35   4.5  
UniRef50_Q55552 Cluster: IMP dehydrogenase; n=8; Cyanobacteria|R...    35   4.5  
UniRef50_Q1NPF0 Cluster: CBS; n=1; delta proteobacterium MLMS-1|...    35   4.5  
UniRef50_Q1LA70 Cluster: 2-nitropropane dioxygenase, NPD; n=1; R...    35   4.5  
UniRef50_Q0F1M3 Cluster: Acetoin utilization protein AcuB; n=1; ...    35   4.5  
UniRef50_A7HKN4 Cluster: 2-nitropropane dioxygenase NPD; n=1; Fe...    35   4.5  
UniRef50_A4ASV9 Cluster: Cyclic nucleotide-binding domain (CNMP-...    35   4.5  
UniRef50_A3WHK4 Cluster: Putative signal-transduction protein wi...    35   4.5  
UniRef50_A1W3D8 Cluster: (S)-2-hydroxy-acid oxidase; n=2; Proteo...    35   4.5  
UniRef50_A1U351 Cluster: FMN-dependent alpha-hydroxy acid dehydr...    35   4.5  
UniRef50_A0JYV5 Cluster: 2-nitropropane dioxygenase, NPD; n=2; A...    35   4.5  
UniRef50_A5BR80 Cluster: Putative uncharacterized protein; n=1; ...    35   4.5  
UniRef50_Q2HCD3 Cluster: Putative uncharacterized protein; n=1; ...    35   4.5  
UniRef50_Q9HKI7 Cluster: Inosine-5'-monophosphate dehydrogenase ...    35   4.5  
UniRef50_Q4JBJ8 Cluster: CBS domain protein; n=4; Sulfolobaceae|...    35   4.5  
UniRef50_Q8G4D5 Cluster: Possible prolidase (X-Pro dipeptidase) ...    35   5.9  
UniRef50_Q81UX7 Cluster: Regulatory protein TenI; n=10; Bacillus...    35   5.9  
UniRef50_Q7NHC3 Cluster: Glr2614 protein; n=1; Gloeobacter viola...    35   5.9  
UniRef50_Q4A6K5 Cluster: Putative N-acetylmannosamine-6-p epimer...    35   5.9  
UniRef50_Q21XZ1 Cluster: CBS domain containing membrane protein;...    35   5.9  
UniRef50_Q1NKC6 Cluster: CBS:Phosphoesterase, RecJ-like:Polynucl...    35   5.9  
UniRef50_Q1F0W8 Cluster: Dihydroorotate dehydrogenase 1; n=1; Cl...    35   5.9  
UniRef50_Q1CWF0 Cluster: Alanine racemase; n=2; Cystobacterineae...    35   5.9  
UniRef50_Q0SII9 Cluster: Probable 2-nitropropane dioxygenase; n=...    35   5.9  
UniRef50_Q0G2G5 Cluster: CBS domain containing membrane protein;...    35   5.9  
UniRef50_Q0FCN2 Cluster: Inosine-5'-monophosphate dehydrogenase;...    35   5.9  
UniRef50_A7BWJ0 Cluster: Cl-channel, voltage gated; n=1; Beggiat...    35   5.9  
UniRef50_A6WDG0 Cluster: CBS domain containing protein precursor...    35   5.9  
UniRef50_A6UKQ5 Cluster: L-lactate dehydrogenase; n=2; Alphaprot...    35   5.9  
UniRef50_A6G8F7 Cluster: CBS domain protein; n=1; Plesiocystis p...    35   5.9  
UniRef50_A6E6Z2 Cluster: Phosphoribosylformimino-5-aminoimidazol...    35   5.9  
UniRef50_A3VMI7 Cluster: L-lactate dehydrogenase; n=3; Rhodobact...    35   5.9  
UniRef50_A3DD07 Cluster: Thiamine-phosphate pyrophosphorylase; n...    35   5.9  
UniRef50_A0FY21 Cluster: Putative signal transduction protein wi...    35   5.9  
UniRef50_Q8MPT5 Cluster: Putative uncharacterized protein T01B6....    35   5.9  
UniRef50_A2QFW7 Cluster: Putative uncharacterized protein; n=1; ...    35   5.9  
UniRef50_A2QBL3 Cluster: Remark: 4 possible sequencing errors we...    35   5.9  
UniRef50_Q8TVZ3 Cluster: CBS-domain; n=1; Methanopyrus kandleri|...    35   5.9  
UniRef50_Q6L002 Cluster: CBS domain containing protein; n=4; The...    35   5.9  
UniRef50_O27293 Cluster: Inosine-5'-monophosphate dehydrogenase ...    35   5.9  
UniRef50_Q12WB7 Cluster: CBS domain protein; n=4; Methanosarcina...    35   5.9  
UniRef50_A0RYM1 Cluster: Phosphate-binding enzymes, TIM-barrel f...    35   5.9  
UniRef50_A0RYL5 Cluster: CBS domain; n=1; Cenarchaeum symbiosum|...    35   5.9  
UniRef50_Q57564 Cluster: Uncharacterized protein MJ0100; n=24; c...    35   5.9  
UniRef50_Q894H0 Cluster: 1-deoxy-D-xylulose-5-phosphate synthase...    35   5.9  
UniRef50_UPI0000DAECD7 Cluster: hypothetical protein CburR_01002...    34   7.8  
UniRef50_UPI00004987F4 Cluster: isopentenyl-diphosphate delta-is...    34   7.8  
UniRef50_Q97L84 Cluster: CBS domains; n=5; Clostridium|Rep: CBS ...    34   7.8  
UniRef50_Q81YV1 Cluster: Glutamate synthase, large subunit, puta...    34   7.8  
UniRef50_Q7NT73 Cluster: Probable TonB-dependent receptor; n=1; ...    34   7.8  
UniRef50_Q72GV4 Cluster: Lactate 2-monooxygenase; n=1; Thermus t...    34   7.8  
UniRef50_Q64WA1 Cluster: Dioxygenase; n=24; cellular organisms|R...    34   7.8  
UniRef50_Q47UD0 Cluster: CBS domain protein; n=2; Alteromonadale...    34   7.8  
UniRef50_Q7WYR2 Cluster: Imidazole glycerol phosphate synthase, ...    34   7.8  
UniRef50_Q3WCL7 Cluster: L-lactate dehydrogenase; n=1; Frankia s...    34   7.8  
UniRef50_Q3ESZ4 Cluster: Enoyl-[acyl-carrier protein] reductase;...    34   7.8  
UniRef50_Q2B3A9 Cluster: Acetoin utilization protein; n=2; Bacil...    34   7.8  
UniRef50_Q1AX99 Cluster: CBS domain containing membrane protein;...    34   7.8  
UniRef50_Q027N8 Cluster: FMN-dependent alpha-hydroxy acid dehydr...    34   7.8  
UniRef50_A6LTL9 Cluster: CBS domain containing protein; n=1; Clo...    34   7.8  
UniRef50_A4VT21 Cluster: L-lactate dehydrogenase (FMN-dependent)...    34   7.8  
UniRef50_A4CMN3 Cluster: Putative uncharacterized protein; n=1; ...    34   7.8  
UniRef50_A4BBH2 Cluster: CBS-domain-containing protein; n=1; Rei...    34   7.8  
UniRef50_A1SFC7 Cluster: CBS domain containing protein; n=1; Noc...    34   7.8  
UniRef50_A0LZM5 Cluster: Protein containing response regulator r...    34   7.8  
UniRef50_A1D3U7 Cluster: CBS and PB1 domain protein; n=17; Ascom...    34   7.8  
UniRef50_Q3IR34 Cluster: CBS domain protein 5; n=2; Halobacteria...    34   7.8  
UniRef50_O26740 Cluster: Conserved protein; n=1; Methanothermoba...    34   7.8  
UniRef50_Q5Y0L9 Cluster: Inosine-5'-monophosphate dehydrogenase;...    34   7.8  
UniRef50_Q5Y0L8 Cluster: Inosine-5'-monophosphate dehydrogenase;...    34   7.8  
UniRef50_A0B5X3 Cluster: Putative signal transduction protein wi...    34   7.8  
UniRef50_P32987 Cluster: Uncharacterized 17.7 kDa protein in bps...    34   7.8  
UniRef50_O67328 Cluster: 1-(5-phosphoribosyl)-5-[(5-phosphoribos...    34   7.8  
UniRef50_P05414 Cluster: Peroxisomal (S)-2-hydroxy-acid oxidase;...    34   7.8  

>UniRef50_P20839 Cluster: Inosine-5'-monophosphate dehydrogenase 1;
           n=135; cellular organisms|Rep: Inosine-5'-monophosphate
           dehydrogenase 1 - Homo sapiens (Human)
          Length = 514

 Score =  739 bits (1826), Expect = 0.0
 Identities = 355/503 (70%), Positives = 419/503 (83%), Gaps = 5/503 (0%)

Query: 11  DGLSAEDTFANSEGLTYNDFLLLPGYIDFTAEEVDLTSPLTKKILLKAPLVSTPMDTVTE 70
           DGL+A+  FA+++GLTYNDFL+LPG+IDF A+EVDLTS LT+KI LK PL+S+PMDTVTE
Sbjct: 16  DGLTAQQLFASADGLTYNDFLILPGFIDFIADEVDLTSALTRKITLKTPLISSPMDTVTE 75

Query: 71  ADMAISMALCGGIGIIHHNCTPEYQANEVHKVKKYKHGFIRDPVCMGPENTVADVLEAKK 130
           ADMAI+MAL GGIG IHHNCTPE+QANEV KVKK++ GFI DPV + P +TV DVLEAK 
Sbjct: 76  ADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVVLSPSHTVGDVLEAKM 135

Query: 131 KNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSL-KEVMTPINDMITAQLGVTLQ 189
           ++GF+G PIT+ G +G +L+GIVTSRDIDF     H +L  EVMTP  +++ A  GVTL+
Sbjct: 136 RHGFSGIPITETGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMTPRIELVVAPAGVTLK 195

Query: 190 DANYILEKSKKGKLPIINNDGELVALIARTDLKKARSYPNASKDSNKQLLVGAAIGTRDT 249
           +AN IL++SKKGKLPI+N+  ELVA+IARTDLKK R YP ASKDS KQLL GAA+GTR+ 
Sbjct: 196 EANEILQRSKKGKLPIVNDCDELVAIIARTDLKKNRDYPLASKDSQKQLLCGAAVGTRED 255

Query: 250 DRERLKLLVNNGVDVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVVTRMQAKNLID 309
           D+ RL LL   GVDVIVLDSSQGNS YQI M+ YIK+ YP +QV+GGNVVT  QAKNLID
Sbjct: 256 DKYRLDLLTQAGVDVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVIGGNVVTAAQAKNLID 315

Query: 310 AGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQSVGHIIK 369
           AGVD LRVGMG GSICITQEVMACG PQ TAVY+VA YAR F VP+IADGGIQ+VGH++K
Sbjct: 316 AGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVPIIADGGIQTVGHVVK 375

Query: 370 SLALGASTVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMESKDGKGSAMSRYFH 429
           +LALGASTVMMGSLLA T+EAPGEYFFSDGVRLKKYRGMGSL+AME      S+  RYF 
Sbjct: 376 ALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAMEK---SSSSQKRYF- 431

Query: 430 KESDKHRVAQGVSGSIVDKGSVLRFLPYLQAGMQHSCQDLGARSVSVLREMSHSGDLRFM 489
            E DK ++AQGVSGSI DKGS+ +F+PYL AG+QH CQD+GARS+SVLR M +SG+L+F 
Sbjct: 432 SEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLRSMMYSGELKFE 491

Query: 490 KRTYSAQLEGNVHGLFSYEKRLF 512
           KRT SAQ+EG VHGL SYEKRL+
Sbjct: 492 KRTMSAQIEGGVHGLHSYEKRLY 514


>UniRef50_P12268 Cluster: Inosine-5'-monophosphate dehydrogenase 2;
           n=30; Euteleostomi|Rep: Inosine-5'-monophosphate
           dehydrogenase 2 - Homo sapiens (Human)
          Length = 514

 Score =  725 bits (1792), Expect = 0.0
 Identities = 350/503 (69%), Positives = 418/503 (83%), Gaps = 5/503 (0%)

Query: 11  DGLSAEDTFANSEGLTYNDFLLLPGYIDFTAEEVDLTSPLTKKILLKAPLVSTPMDTVTE 70
           DGL+A+  F   +GLTYNDFL+LPGYIDFTA++VDLTS LTKKI LK PLVS+PMDTVTE
Sbjct: 16  DGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTE 75

Query: 71  ADMAISMALCGGIGIIHHNCTPEYQANEVHKVKKYKHGFIRDPVCMGPENTVADVLEAKK 130
           A MAI+MAL GGIG IHHNCTPE+QANEV KVKKY+ GFI DPV + P++ V DV EAK 
Sbjct: 76  AGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKA 135

Query: 131 KNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPH-LSLKEVMTPINDMITAQLGVTLQ 189
           ++GF G PIT  G++G RL+GI++SRDIDF + + H   L+E+MT   D++ A  G+TL+
Sbjct: 136 RHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMTKREDLVVAPAGITLK 195

Query: 190 DANYILEKSKKGKLPIINNDGELVALIARTDLKKARSYPNASKDSNKQLLVGAAIGTRDT 249
           +AN IL++SKKGKLPI+N D ELVA+IARTDLKK R YP ASKD+ KQLL GAAIGT + 
Sbjct: 196 EANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHED 255

Query: 250 DRERLKLLVNNGVDVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVVTRMQAKNLID 309
           D+ RL LL   GVDV+VLDSSQGNS +QI MIKYIK+ YP +QV+GGNVVT  QAKNLID
Sbjct: 256 DKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLID 315

Query: 310 AGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQSVGHIIK 369
           AGVDALRVGMGSGSICITQEV+ACG PQATAVY+V+ YAR F VPVIADGGIQ+VGHI K
Sbjct: 316 AGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAK 375

Query: 370 SLALGASTVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMESKDGKGSAMSRYFH 429
           +LALGASTVMMGSLLA T+EAPGEYFFSDG+RLKKYRGMGSL+AM   D   S+ +RYF 
Sbjct: 376 ALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM---DKHLSSQNRYF- 431

Query: 430 KESDKHRVAQGVSGSIVDKGSVLRFLPYLQAGMQHSCQDLGARSVSVLREMSHSGDLRFM 489
            E+DK +VAQGVSG++ DKGS+ +F+PYL AG+QHSCQD+GA+S++ +R M +SG+L+F 
Sbjct: 432 SEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFE 491

Query: 490 KRTYSAQLEGNVHGLFSYEKRLF 512
           KRT SAQ+EG VH L SYEKRLF
Sbjct: 492 KRTSSAQVEGGVHSLHSYEKRLF 514


>UniRef50_P21620 Cluster: Inosine-5'-monophosphate dehydrogenase;
           n=11; Eukaryota|Rep: Inosine-5'-monophosphate
           dehydrogenase - Leishmania donovani
          Length = 514

 Score =  516 bits (1272), Expect = e-145
 Identities = 250/504 (49%), Positives = 352/504 (69%), Gaps = 6/504 (1%)

Query: 9   LRDGLSAEDTFANSEGLTYNDFLLLPGYIDFTAEEVDLTSPLTKKILLKAPLVSTPMDTV 68
           ++DG +AE+ F   +GLTYNDF++LPG+IDF A +V+++   TK+I L  P+VS+PMDT+
Sbjct: 13  IKDGCTAEELF-RGDGLTYNDFIILPGFIDFGAADVNISGQFTKRIRLHIPIVSSPMDTI 71

Query: 69  TEADMAISMALCGGIGIIHHNCTPEYQANEVHKVKKYKHGFIRDPVCMGPENTVADVLEA 128
           TE +MA +MAL GG+G++H+NCT E Q   V  VK Y++GFI  P  + P   +++++  
Sbjct: 72  TENEMAKTMALMGGVGVLHNNCTVERQVEMVKSVKAYRNGFISKPKSVPPNTPISNIIRI 131

Query: 129 KKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLKEVMTPINDMITAQLGVTL 188
           K++ G +G  +T+NG   G+L+GIV ++DID+ + +    +  VMT    M   +  + L
Sbjct: 132 KEEKGISGILVTENGDPHGKLLGIVCTKDIDYVK-NKDTPVSAVMTRREKMTVERAPIQL 190

Query: 189 QDANYILEKSKKGKLPIINNDGELVALIARTDLKKARSYPNASKDSNKQLLVGAAIGTRD 248
           ++A  +L +S+ G LPI+N + E+V L +R D  +AR YP+++ D + +L+  AA  TR 
Sbjct: 191 EEAMDVLNRSRYGYLPIVNENDEVVNLCSRRDAVRARDYPHSTLDKSGRLICAAATSTRP 250

Query: 249 TDRERLKLLVNNGVDVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVVTRMQAKNLI 308
            D+ R+  L + GVDV+VLDSSQGN+ YQI  IK++K TYP ++VV GNVVT+ QAKNLI
Sbjct: 251 EDKRRVAALADVGVDVLVLDSSQGNTIYQIAFIKWVKSTYPHLEVVAGNVVTQDQAKNLI 310

Query: 309 DAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQSVGHII 368
           DAG D +R+GMGSGSICITQEV+ACG PQ TAVY+VA Y     VP  ADGG++ VG I 
Sbjct: 311 DAGADGIRIGMGSGSICITQEVLACGRPQGTAVYKVAQYCASRGVPCTADGGLRQVGDIC 370

Query: 369 KSLALGASTVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMESKDGKGSAMSRYF 428
           K+LA+GA+  M+G +L+GT+E PGEYFF  GVRLK YRGMGSLEAM    GK S   RY 
Sbjct: 371 KALAIGANCAMLGGMLSGTTETPGEYFFKGGVRLKVYRGMGSLEAM--SQGKESG-KRYL 427

Query: 429 HKESDKHRVAQGVSGSIVDKGSVLRFLPYLQAGMQHSCQDLGARSVSVLREMSHSGDLRF 488
             E++  +VAQGVSG++VDKGS  + + Y+  G+Q S QD+G  S   +RE  ++G + F
Sbjct: 428 -SENEAVQVAQGVSGNVVDKGSAAKLIAYVSKGLQQSAQDIGEISFDAIREKMYAGQVLF 486

Query: 489 MKRTYSAQLEGNVHGLFSYEKRLF 512
            +R+ +AQ EG VH L SYEK+LF
Sbjct: 487 SRRSPTAQGEGGVHSLHSYEKKLF 510


>UniRef50_O96387 Cluster: Inosine-5'-monophosphate dehydrogenase;
           n=3; Plasmodium|Rep: Inosine-5'-monophosphate
           dehydrogenase - Plasmodium falciparum
          Length = 510

 Score =  490 bits (1208), Expect = e-137
 Identities = 242/511 (47%), Positives = 339/511 (66%), Gaps = 10/511 (1%)

Query: 9   LRDGLSAEDTFANSEGLTYNDFLLLPGYIDFTAEEVDLTSPLTKKILLKAPLVSTPMDTV 68
           +  G  A++ F      TY+  + +PGYIDF   ++DLT+ +T  I LK P++S+PMDTV
Sbjct: 1   MASGWKADEVFGGVMSYTYDVIICMPGYIDFALSDIDLTNNMTDNITLKTPVISSPMDTV 60

Query: 69  TEADMAISMALCGGIGIIHHNCTPEYQANEVHKVKKYKHGFIRDPVCMGPENTVADVLEA 128
           T   M+I++AL GG+G+IH+N + E Q  EV KVK++++GFI DP    PE+TVADVLE 
Sbjct: 61  TGHKMSIALALSGGLGVIHNNMSIEKQIEEVKKVKRFENGFIFDPYTFSPEHTVADVLET 120

Query: 129 KKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLKEVMTPINDMITAQLGVTL 188
           K + G+  YPIT +GK+G +L+GI+T  D  +   +  + + ++MT   D++T    + L
Sbjct: 121 KNRVGYKSYPITVDGKVGSKLVGIITGIDYLYLT-NKSMKIGDIMT--TDVVTGSYPINL 177

Query: 189 QDANYILEKSKKGKLPIINNDGELVALIARTDLKKARSYPNASKDSNKQLLVGAAIGTRD 248
            DAN +L   KK  LPI+N + EL+AL+ R D+ K R +P+ASK  NKQL+VGA+I TR+
Sbjct: 178 SDANKVLCDEKKSVLPIVNKNNELIALVCRNDMHKNRIFPHASKSQNKQLIVGASISTRE 237

Query: 249 TDRERLKLLVNNGVDVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVVTRMQAKNLI 308
            D ER   L+ N +DVI +DSSQGNS YQI  IK IK  +P+I ++GGNVVT  QAKNLI
Sbjct: 238 HDLERANQLIKNMIDVICIDSSQGNSIYQIDTIKKIKSAHPDIPIIGGNVVTSQQAKNLI 297

Query: 309 DAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQSVGHII 368
           DAG D LR+GMGSGSIC TQ+V A G  Q TAVY V+ YA   N+  IADGGI++ G+I+
Sbjct: 298 DAGADVLRIGMGSGSICTTQDVCAVGRAQGTAVYHVSKYAHTRNIKTIADGGIKNSGNIV 357

Query: 369 KSLALGASTVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMESKDGKGSA----- 423
           K+L+LGA  VM+G+LLA T E+  EY+F + VRLK YRGMGS+EAM +K     +     
Sbjct: 358 KALSLGADFVMLGNLLAATEESCSEYYFENNVRLKIYRGMGSMEAMYNKGFNSKSRYLVD 417

Query: 424 --MSRYFHKESDKHRVAQGVSGSIVDKGSVLRFLPYLQAGMQHSCQDLGARSVSVLREMS 481
              + Y  +  D+ +V+QGVS S+VDKGSVL  +P+L   ++H  Q +G R++  L    
Sbjct: 418 ERKNEYTDENIDEIKVSQGVSASLVDKGSVLNLIPHLFKAVKHGFQSMGIRNIPELHSKL 477

Query: 482 HSGDLRFMKRTYSAQLEGNVHGLFSYEKRLF 512
           +SGD+RF  R+++   EG V     +  + F
Sbjct: 478 YSGDIRFDVRSFNTIKEGKVSDNLIFNNKKF 508


>UniRef50_Q01F10 Cluster: IpdH inosine 5'-phosphate dehydrogenase;
           n=2; Ostreococcus|Rep: IpdH inosine 5'-phosphate
           dehydrogenase - Ostreococcus tauri
          Length = 502

 Score =  481 bits (1187), Expect = e-134
 Identities = 243/502 (48%), Positives = 342/502 (68%), Gaps = 10/502 (1%)

Query: 11  DGLSAEDTFANSEGLTYNDFLLLPGYIDFTAEEVDLTSPLTKKILLKAPLVSTPMDTVTE 70
           DG SAE  F      TY+D +  PG+IDF A++VDL++ +++ I ++ PLVS+PMDTVTE
Sbjct: 5   DGYSAEVLFNQGFCYTYDDVIFHPGFIDFAADQVDLSTRVSRNITIRTPLVSSPMDTVTE 64

Query: 71  ADMAISMALCGGIGIIHHNCTPEYQANEVHKVKKYKHGFIRDPVCMGPENTVADVLEAKK 130
           ++MA++MA  GG+G +H+N T E Q   V +VK +  G++ +P  MGP  T++++ +   
Sbjct: 65  SEMAVAMAEVGGMGFLHYNMTMESQVEHVKRVKSHNPGYVANPAIMGPSATLSELDKLLT 124

Query: 131 KNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLKEVMTPINDMITAQLGVTLQD 190
             GFT   +T++G   G L+G+VT+RDI+F   D   +L EVMT +  ++     +TLQ+
Sbjct: 125 ARGFTSVCVTEDGASEGTLLGLVTTRDIEFVR-DRTTALSEVMTTVGKLVLGSTDMTLQE 183

Query: 191 ANYILEKSKKGKLPIINNDGELVALIARTDLKKARSYPNASK---DSNKQLLVGAAIGTR 247
               L + K+GKLPI+N  G L  L+ R ++K   + P A     D++ +LL GAAIGTR
Sbjct: 184 NETTLLECKRGKLPIVNRHGCLTGLLTRANVKARLNRPAAGAPALDNHGKLLCGAAIGTR 243

Query: 248 DTDRERLKLLVNNGVDVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVVTRMQAKNL 307
           DTDR R + L   GV+ I+LDSSQG+S YQ++MIK++K   P++ V+ GNVVT+ QA+ L
Sbjct: 244 DTDRVRAQQLFGAGVNAIILDSSQGDSVYQLEMIKFLKNELPQLDVIAGNVVTQQQARRL 303

Query: 308 IDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQSVGHI 367
           ++AG D LRVGMGSGSIC TQEV A G  QATAVY+V   AR F+VP+IADGGIQ+ GHI
Sbjct: 304 LEAGADGLRVGMGSGSICTTQEVCAVGRGQATAVYKVGQVAREFDVPIIADGGIQNSGHI 363

Query: 368 IKSLALGASTVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMESKDGKGSAMSRY 427
           +K+LALGA+  M GS+ +G++EAPG+YF+ DG R+KKYRGMGSL+AM+    KGS  SRY
Sbjct: 364 VKALALGANVAMCGSVFSGSTEAPGQYFYQDGARVKKYRGMGSLDAMK----KGSD-SRY 418

Query: 428 FHKESDKHRVAQGVSGSIVDKGSVLRFLPYLQAGMQHSCQDLGARSVSVLREMSHSGDLR 487
              ES   ++AQGVSG++ DKGS+   +PYL  G +   QDLGA S+  + +M  +G + 
Sbjct: 419 L-SESGHLKIAQGVSGTVRDKGSIKSTIPYLIHGAKQGFQDLGADSLEKVHQMLANGLMT 477

Query: 488 FMKRTYSAQLEGNVHGLFSYEK 509
              RT +AQ EG +H + SY K
Sbjct: 478 MEVRTNAAQKEGGIHDMHSYTK 499


>UniRef50_Q4VRV8 Cluster: Inosine 5'monophosphate dehydrogenase;
           n=2; Toxoplasma gondii|Rep: Inosine 5'monophosphate
           dehydrogenase - Toxoplasma gondii
          Length = 551

 Score =  481 bits (1186), Expect = e-134
 Identities = 238/410 (58%), Positives = 306/410 (74%), Gaps = 5/410 (1%)

Query: 9   LRDGLSAEDTFANSE-GLTYNDFLLLPGYIDFTAEEVDLTSPLTKKILLKAPLVSTPMDT 67
           + DG  AE  F  +  G TY+D +L+PG+IDF   +VDL++ +T+ + ++ P+VS+PMDT
Sbjct: 1   MADGWDAEKIFNTTVFGFTYDDLILMPGHIDFGVNDVDLSTRITRNLHVRTPIVSSPMDT 60

Query: 68  VTEADMAISMALCGGIGIIHHNCTPEYQANEVHKVKKYKHGFIRDPVCMGPENTVADVLE 127
           VTE  MAI  AL GG+G+IH+N     Q  EV KVK+Y++GFI DP  + P ++VADV  
Sbjct: 61  VTEHRMAIGCALMGGMGVIHNNMETARQVAEVQKVKRYENGFILDPFVLRPSDSVADVYR 120

Query: 128 AKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLKEVMTPINDMITAQLGVT 187
            K+K G++  PIT  G LGG+L+GIVTSRDIDF   D H  L EVMT  +D++     V 
Sbjct: 121 IKEKYGYSSVPITDTGMLGGKLLGIVTSRDIDFLT-DVHTPLSEVMT--SDLVVGHEPVQ 177

Query: 188 LQDANYILEKSKKGKLPIINNDGELVALIARTDLKKARSYPNASKDSNKQLLVGAAIGTR 247
           L +AN +L +SKKGKLPI+N++ ELVALI+R DLKK R +P ASKDSNKQLLVGAA+ T+
Sbjct: 178 LAEANELLRESKKGKLPIVNDNFELVALISRNDLKKNREFPLASKDSNKQLLVGAAVSTK 237

Query: 248 DTDRERLKLLVNNGVDVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVVTRMQAKNL 307
             D ER K L   G DV+V+DSSQG+S YQ+ ++K +K  +PE+Q++GGNVVT  QAK+L
Sbjct: 238 PHDIERAKALQEAGADVLVVDSSQGDSIYQVDLVKRLKAAFPELQIIGGNVVTARQAKSL 297

Query: 308 IDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYAR-HFNVPVIADGGIQSVGH 366
           IDAGVD LR+GMGSGSIC TQ V A G  QATAVY V  YAR H +VP IADGGIQ+ GH
Sbjct: 298 IDAGVDGLRIGMGSGSICTTQVVCAVGRAQATAVYHVCKYAREHGDVPCIADGGIQNSGH 357

Query: 367 IIKSLALGASTVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMES 416
           ++K+LALGA+ VMMGS+LAGT EAPGEY+F +GVR+K YRGMGSL+AM +
Sbjct: 358 VMKALALGANAVMMGSMLAGTEEAPGEYYFHNGVRVKTYRGMGSLDAMRA 407



 Score = 91.9 bits (218), Expect = 4e-17
 Identities = 47/101 (46%), Positives = 69/101 (68%), Gaps = 2/101 (1%)

Query: 412 EAMESKDGKGSAMSRYFHKESDKHRVAQGVSGSIVDKGSVLRFLPYLQAGMQHSCQDLGA 471
           EA  +    GSA +RYF  E+   RVAQGVSG +VDKG+V++ +PY+  G++H  QD+GA
Sbjct: 452 EASRTSTSTGSA-ARYF-AENQTIRVAQGVSGCVVDKGTVMQLIPYVIQGVKHGMQDIGA 509

Query: 472 RSVSVLREMSHSGDLRFMKRTYSAQLEGNVHGLFSYEKRLF 512
           R++  L      G+LRF  R+ +AQ EG+VH L S+E++L+
Sbjct: 510 RTLRDLHAQLVGGELRFDVRSGAAQREGDVHDLHSFERKLY 550


>UniRef50_Q4UCL4 Cluster: Inosine-5'-monophosphate dehydrogenase,
           putative; n=7; Aconoidasida|Rep:
           Inosine-5'-monophosphate dehydrogenase, putative -
           Theileria annulata
          Length = 511

 Score =  472 bits (1163), Expect = e-131
 Identities = 244/507 (48%), Positives = 353/507 (69%), Gaps = 18/507 (3%)

Query: 9   LRDGLSAEDTFANSE-GLTYNDFLLLPGYIDFTAEEVDLTSPLTKKILLKAPLVSTPMDT 67
           + DG SA + F  ++  L+Y D ++LPGYI  + ++VDL+S +T+ I L+ P++S+PMDT
Sbjct: 1   MADGYSAAEFFNFTKLSLSYEDLIILPGYIRDSVDKVDLSSNVTRNIKLRIPILSSPMDT 60

Query: 68  VTEADMAISMALCGGIGIIHHNCTPEYQANEVHKVKKYKHGFIRDPVCMGPENTVADVLE 127
           VTE+ MA +MAL GG+G+IH+N + +    EV  VK++++GF+ +PVC+ P +TV+D +E
Sbjct: 61  VTESKMATAMALLGGLGVIHNNLSIDNLIKEVKAVKRFENGFVHNPVCLKPTSTVSDWVE 120

Query: 128 AKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLKEVMTPINDMITAQLGVT 187
            + K GFT  PIT +G  G +L+GIVT  D+ F E   ++SL+E+M+   +++  +  + 
Sbjct: 121 IRDKLGFTSVPITSDGNPGSKLLGIVTKTDMYFVE-SKNVSLEEIMS--TNLVVGKHPMK 177

Query: 188 LQDANYILEKSKKGKLPIINNDGELVALIARTDLKKARSYPNASKDSNKQLLVGAAIGTR 247
           L DAN +L  SKKG LPI+N D EL++++ R+D  K++ YP ASKD NKQLLVGAAI T 
Sbjct: 178 LNDANELLFMSKKGVLPIVNEDYELMSIVTRSDFYKSKLYPYASKDDNKQLLVGAAISTN 237

Query: 248 D----TDR----ERLKLLVNNGVDVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVV 299
           +     DR    E  K L++  VDVI++DSSQGNS +QI +IK +K  YP +Q++GGNVV
Sbjct: 238 NFANGFDRVNGLEVAKKLIDAKVDVILVDSSQGNSVFQIDLIKQLKSAYPNVQIIGGNVV 297

Query: 300 TRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYA-RHFN-VPVIA 357
           +  QAKN+++AG D+++VGMG GSIC TQ +   G  QAT+VY V+ Y   H+N VPVIA
Sbjct: 298 SAQQAKNVLEAGCDSIKVGMGIGSICTTQNICGVGRGQATSVYYVSRYTFEHWNGVPVIA 357

Query: 358 DGGIQSVGHIIKSLALGASTVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAME-- 415
           DGGI++ G I+K+L+LGAS VM GS+ AG+ EAPGEY+F++GVR+K YRGMGS +A+   
Sbjct: 358 DGGIKTSGDIVKALSLGASCVMGGSIFAGSKEAPGEYYFNNGVRMKSYRGMGSKDAINDS 417

Query: 416 -SKDGKGSAMSRYFHKESDKHRVAQGVSGSIVDKGSVLRFLPYLQAGMQHSCQDLGARSV 474
               G   ++SRY H   D+  ++QGVSG ++DKGSV   LP L  G++H  Q++GA SV
Sbjct: 418 LQNTGLMGSLSRY-HLVDDQKIISQGVSGLVIDKGSVNNILPNLTQGVKHGLQNIGAFSV 476

Query: 475 SVLREMSHSGDLRFMKRTYSAQLEGNV 501
             L E  +SG LR  +RT  + ++ NV
Sbjct: 477 KELHEALYSGQLRLEQRTAQSIVDANV 503


>UniRef50_P47996 Cluster: Inosine-5'-monophosphate dehydrogenase;
           n=9; core eudicotyledons|Rep: Inosine-5'-monophosphate
           dehydrogenase - Arabidopsis thaliana (Mouse-ear cress)
          Length = 503

 Score =  434 bits (1069), Expect = e-120
 Identities = 235/512 (45%), Positives = 332/512 (64%), Gaps = 20/512 (3%)

Query: 9   LRDGLSAEDTFANSEGLTYNDFLLLPGYIDFTAEEVDLTSPLTKKILLKAPLVSTPMDTV 68
           L DG  A+  FA     TY+D + LP +IDF+ + V L++ L++++ L  P VS+PMDTV
Sbjct: 4   LEDGFPADKLFAQGYSYTYDDVIFLPHFIDFSTDAVSLSTRLSRRVPLSIPCVSSPMDTV 63

Query: 69  TEADMAISMALCGGIGIIHHNCTPEYQANEVHKVKKYKHGFIRDPVCMGPENTVADVLEA 128
           +E+ MA +MA  GGIGI+H+NC    QA+ + + K  KH    D     PE  +   L+A
Sbjct: 64  SESHMAAAMASLGGIGIVHYNCGIAAQASIIRQAKSLKHPIASDAGVKFPEYEITS-LDA 122

Query: 129 KKKNGFTGYPITQNGKLGG-RLIGIVTS---RDIDFREGDPHLSLKEVMTPINDM-ITAQ 183
              + F    + Q G +   +L+G VT    + +++ + +  + + + M   +       
Sbjct: 123 FGPSSFVF--VEQTGTMTTPKLLGYVTKSQWKRMNYEQRE--MKIYDYMKSCDSSDYCVP 178

Query: 184 LGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKARSYPNASKDS---NKQLLV 240
             +  +   ++LE  +KG + ++  DGE V ++ + D+++ + YP +   +   + + +V
Sbjct: 179 WEIDFEKLEFVLEDKQKGFV-VLERDGETVNVVTKDDIQRVKGYPKSGPGTVGPDGEWMV 237

Query: 241 GAAIGTRDTDRERLKLLVNNGVDVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVVT 300
           GAAIGTR++D+ERL+ LVN GV+ +VLDSSQGNS YQ++MIKY+K+TYPE+ V+GGNVVT
Sbjct: 238 GAAIGTRESDKERLEHLVNVGVNAVVLDSSQGNSIYQLEMIKYVKKTYPELDVIGGNVVT 297

Query: 301 RMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFNVPVIADGG 360
             QA+NLI AGVD LRVGMGSGSIC TQEV A G  QATAVY+V S A    +PVIADGG
Sbjct: 298 MYQAQNLIQAGVDGLRVGMGSGSICTTQEVCAVGRGQATAVYKVCSIAAQSGIPVIADGG 357

Query: 361 IQSVGHIIKSLALGASTVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMESKDGK 420
           I + GHI+K+L LGASTVMMGS LAG++EAPG Y +++G R+KKYRGMGSLEAM     K
Sbjct: 358 ISNSGHIVKALVLGASTVMMGSFLAGSTEAPGGYEYTNGKRIKKYRGMGSLEAMT----K 413

Query: 421 GSAMSRYFHKESDKHRVAQGVSGSIVDKGSVLRFLPYLQAGMQHSCQDLGARSVSVLREM 480
           GS   RY   ++ K ++AQGV G++ DKGSVL+ +PY    ++   QDLGA S+     +
Sbjct: 414 GSD-QRYLGDQT-KLKIAQGVVGAVADKGSVLKLIPYTMHAVKQGFQDLGASSLQSAHGL 471

Query: 481 SHSGDLRFMKRTYSAQLEGNVHGLFSYEKRLF 512
             S  LR   RT +AQ+EG VHGL SYEK+ F
Sbjct: 472 LRSNILRLEARTGAAQVEGGVHGLVSYEKKSF 503


>UniRef50_A7QMJ8 Cluster: Chromosome chr19 scaffold_126, whole
           genome shotgun sequence; n=1; Vitis vinifera|Rep:
           Chromosome chr19 scaffold_126, whole genome shotgun
           sequence - Vitis vinifera (Grape)
          Length = 578

 Score =  427 bits (1053), Expect = e-118
 Identities = 240/508 (47%), Positives = 327/508 (64%), Gaps = 19/508 (3%)

Query: 9   LRDGLSAEDTFANSEGLTYNDFLLLPGYIDFTAEEVDLTSPLTKKILLKAPLVSTPMDTV 68
           + DG  A   F      TY+D +  PGYIDF A+ V L + L++ + L  P V++PMDTV
Sbjct: 86  IEDGFPAVKLFNQGYSYTYDDVIFHPGYIDFPADAVQLGTKLSRNVHLSIPCVASPMDTV 145

Query: 69  TEADMAISMALCGGIGIIHHNCTPEYQANEVHKVKKYKHGFIRDPVCMGPENTVADVLEA 128
           TE+ MA++MA  GG+GIIH N +   QA  V   K  +  F+ DPV     ++V  V + 
Sbjct: 146 TESAMAVAMATVGGVGIIHSNNSAAEQAALVRSAKSRRVPFVSDPVVKSAFDSVDSVSDF 205

Query: 129 KKKNGFTGYP-ITQNGKLGGRLIGIVTSRDIDFREGDPHLSLKEVMTPINDMITAQLGVT 187
               G   Y  +T++G    +++G+V   D + +  D  + + E M    + + A     
Sbjct: 206 ----GSAPYVLVTESGTAKSKMLGVVLRSDWE-KLSDKGVKVCEYMVSSPESVPASYDFE 260

Query: 188 LQDANYILEKSKKGKLPIINNDGELVALIARTDLKKARSYPNA---SKDSNKQLLVGAAI 244
            Q A Y+  K K   +P++ +D E+V ++   D+++ R +P     S D+  + LVGAAI
Sbjct: 261 -QVAGYLAAK-KLSFVPLVRDD-EVVDVVTTADVERIRGFPKLGMPSLDAKGEFLVGAAI 317

Query: 245 GTRDTDRERLKLLVNNGVDVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVVTRMQA 304
           GTR++D+ERL+ LV  G +VIVLDSSQGNS YQI+M KY K+ +PE+ V+GGNVVT  QA
Sbjct: 318 GTRESDKERLEHLVKAGANVIVLDSSQGNSIYQIEMTKYAKKMFPEVDVIGGNVVTIRQA 377

Query: 305 KNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQSV 364
           +NLI AGVD LRVGMGSGSIC TQEV A G  QATAVY+V+S A    VPVIADGGI + 
Sbjct: 378 QNLIQAGVDGLRVGMGSGSICTTQEVCAVGRGQATAVYKVSSIAERSGVPVIADGGISNS 437

Query: 365 GHIIKSLALGASTVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMESKDGKGSAM 424
           GHI+K+L LGASTVMMGS LAG+SEAPG Y   +G+++KKYRGMGSLEAM     KGS  
Sbjct: 438 GHIVKALTLGASTVMMGSFLAGSSEAPGAYENKNGLKIKKYRGMGSLEAMT----KGSD- 492

Query: 425 SRYFHKESDKHRVAQGVSGSIVDKGSVLRFLPYLQAGMQHSCQDLGARSVSVLREMSHSG 484
           +RY   ++ K ++AQGV G++ DKGSVL+F+PY    ++   QDLGA S+    ++  S 
Sbjct: 493 ARYL-GDTAKLKIAQGVVGAVADKGSVLKFIPYTMQAVKQGFQDLGASSLQSAHDLLRS- 550

Query: 485 DLRFMKRTYSAQLEGNVHGLFSYEKRLF 512
           +LR   RT +AQ+EG VHGL S+EK+ F
Sbjct: 551 ELRLEVRTGAAQVEGGVHGLVSHEKKYF 578


>UniRef50_Q4SBU2 Cluster: Chromosome 19 SCAF14664, whole genome
           shotgun sequence; n=3; Tetraodontidae|Rep: Chromosome 19
           SCAF14664, whole genome shotgun sequence - Tetraodon
           nigroviridis (Green puffer)
          Length = 571

 Score =  419 bits (1031), Expect = e-115
 Identities = 213/322 (66%), Positives = 250/322 (77%), Gaps = 3/322 (0%)

Query: 11  DGLSAEDTFANSEGLTYNDFLLLPGYIDFTAEEV-DLTSPLT-KKILLKAPLVSTPMDTV 68
           DGLSA+  F+  +GLTY            TAEE+      LT KKI LK PL+S+PMDTV
Sbjct: 17  DGLSAQQLFSIGDGLTYKSDQQCVVSDGHTAEELCSKGDGLTYKKITLKTPLISSPMDTV 76

Query: 69  TEADMAISMALCGGIGIIHHNCTPEYQANEVHKVKKYKHGFIRDPVCMGPENTVADVLEA 128
           TE+ MAI+MAL GGIGIIHHNCTPE+QANEV KVK+++ GFI DPV M P +TV DV+EA
Sbjct: 77  TESAMAIAMALMGGIGIIHHNCTPEFQANEVRKVKRFEQGFITDPVVMSPRHTVGDVVEA 136

Query: 129 KKKNGFTGYPITQNGKLGGRLIGIVTSRDIDF-REGDPHLSLKEVMTPINDMITAQLGVT 187
           K ++GF+G PIT+ GK+G +L+GIVTSRDIDF  E D    L+E MT   D++ A  GVT
Sbjct: 137 KTRHGFSGIPITETGKMGSKLVGIVTSRDIDFLSEKDHDKPLEEAMTKREDLVVAPAGVT 196

Query: 188 LQDANYILEKSKKGKLPIINNDGELVALIARTDLKKARSYPNASKDSNKQLLVGAAIGTR 247
           L++AN IL++SKKGKLPI+NN+ ELVA+IARTDLKK R YP ASKDS KQLL GAAIGTR
Sbjct: 197 LKEANDILQRSKKGKLPIVNNNDELVAIIARTDLKKNRDYPLASKDSRKQLLCGAAIGTR 256

Query: 248 DTDRERLKLLVNNGVDVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVVTRMQAKNL 307
           D D+ RL LLV  GVDV+VLDSSQGNS +QI MI YIK+ Y ++QVVGGNVVT  QAKNL
Sbjct: 257 DDDKYRLDLLVQAGVDVVVLDSSQGNSVFQISMINYIKQKYADLQVVGGNVVTAAQAKNL 316

Query: 308 IDAGVDALRVGMGSGSICITQE 329
           IDAGVDALRVGMG GSICITQE
Sbjct: 317 IDAGVDALRVGMGCGSICITQE 338



 Score =  260 bits (637), Expect = 6e-68
 Identities = 124/177 (70%), Positives = 150/177 (84%), Gaps = 4/177 (2%)

Query: 330 VMACGCPQATAVYQVASYARHFNVPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSE 389
           VMACG PQ T+VY+VA YAR F+VPVIADGGIQ+VGH++K+L+LGASTVMMGSLLA T+E
Sbjct: 399 VMACGRPQGTSVYKVAEYARRFSVPVIADGGIQTVGHVVKALSLGASTVMMGSLLAATTE 458

Query: 390 APGEYFFSDGVRLKKYRGMGSLEAMESKDGKGSAMSRYFHKESDKHRVAQGVSGSIVDKG 449
           APGEYFF+DGVRLKKYRGMGSL+AME      S+  RYF  E DK +VAQGVSGS+ DKG
Sbjct: 459 APGEYFFADGVRLKKYRGMGSLDAMEKST---SSQKRYF-SEGDKVKVAQGVSGSVQDKG 514

Query: 450 SVLRFLPYLQAGMQHSCQDLGARSVSVLREMSHSGDLRFMKRTYSAQLEGNVHGLFS 506
           S+ +F+PYL AG+QH CQD+GA+S+S+LR M +SG+L+F KRT SAQ+EG VHGL S
Sbjct: 515 SIHKFVPYLIAGIQHGCQDIGAKSLSILRSMMYSGELKFEKRTMSAQVEGGVHGLHS 571


>UniRef50_A6R4D7 Cluster: Inosine-5'-monophosphate dehydrogenase;
           n=1; Ajellomyces capsulatus NAm1|Rep:
           Inosine-5'-monophosphate dehydrogenase - Ajellomyces
           capsulatus NAm1
          Length = 508

 Score =  383 bits (943), Expect = e-105
 Identities = 231/515 (44%), Positives = 316/515 (61%), Gaps = 59/515 (11%)

Query: 11  DGLSAEDTFANSE--GLTYNDFLLLPGYIDFTAEEVDLTSPLTKKILLKAPLVSTPMDTV 68
           DGL       + +   LTYNDFL+LPGYI F A +V L +P+T++I LKAPL+S+PMDTV
Sbjct: 39  DGLDINQLIDSEKRGALTYNDFLILPGYIGFPASDVSLETPVTRRITLKAPLLSSPMDTV 98

Query: 69  TEADMAISMALCGGIGIIHHNCTPEYQANEVHKVKKYKHGFIRDPVCMGPENTVADVLEA 128
           TE  MAI MAL GG+G+IHHNC+ E QAN V KVK+Y++GFI +PV + P  TVA+    
Sbjct: 99  TEHSMAIHMALLGGLGVIHHNCSAEDQANMVRKVKRYENGFILEPVVLSPTTTVAEAKAL 158

Query: 129 KKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLKEVMTPINDMITAQLGVTL 188
           K+K GF G+P+T+NG L  +LIG++TSRDI F        +  VMT   D++TA  G TL
Sbjct: 159 KEKWGFGGFPVTENGTLPSKLIGMITSRDIQFHPTGED-PVPAVMT--TDLLTAPSGTTL 215

Query: 189 QDANYILEKSKKGKLPIINNDGELVALIARTDLKKARSYPNASKDSNKQLLVGAAIGTRD 248
            +AN +    ++  LP +                 A   P+     +KQL+  AAI TR 
Sbjct: 216 AEANEV-RSHEEPSLPYL-----------------ASKLPH-----SKQLICAAAICTRP 252

Query: 249 TDRERLKLLVNNGVDVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVVTRMQAKNLI 308
            D+ERL  L+  G+D+++LDSSQGNS YQI+MIKY  +  P +  V            ++
Sbjct: 253 EDKERLPKLIEAGLDIVILDSSQGNSIYQIEMIKYRTKQLPLLPQV-----------RMV 301

Query: 309 DAGVDALRVGMGSGSICITQEVMACGCP--QATAVYQVASYARHFNVPVIADGGIQSVGH 366
              V A  V      +   +++   G P  Q  AVY    +A     PV+     + + H
Sbjct: 302 SVLVWAAEV------LASHKKLWPSGDPRLQLCAVYPNLLHAS--ESPVLRMAVFRILAH 353

Query: 367 IIKSLALGASTVMMGSLLAGTSEAPGEYFFS-DGVRLKKYRGMGSLEAMESK---DGKG- 421
           I+K LA+GA+TVMMG LLAGT+E+PG YF S +G  +K YRGMGS++AME K    GKG 
Sbjct: 354 IVKGLAMGATTVMMGGLLAGTTESPGSYFVSREGQLVKAYRGMGSIDAMEDKKAGGGKGG 413

Query: 422 ----SAMSRYFHKESDKHRVAQGVSGSIVDKGSVLRFLPYLQAGMQHSCQDLGARSVSVL 477
               +  +RYF  ESD+  VAQGVSGS++D+GSV +F+PYL AG+QHS QD+G +S+  L
Sbjct: 414 QANNAGTARYF-SESDRLLVAQGVSGSVLDRGSVTKFVPYLMAGIQHSLQDIGVKSLKEL 472

Query: 478 REMSHSGDLRFMKRTYSAQLEGNVHGLFSYEKRLF 512
            +   +G +RF  R+ SAQ EG VHGL S++K+L+
Sbjct: 473 HDGVAAGTVRFEVRSVSAQAEGGVHGLHSFDKKLY 507


>UniRef50_O67820 Cluster: Inosine-5'-monophosphate dehydrogenase;
           n=59; cellular organisms|Rep: Inosine-5'-monophosphate
           dehydrogenase - Aquifex aeolicus
          Length = 490

 Score =  375 bits (923), Expect = e-102
 Identities = 207/481 (43%), Positives = 301/481 (62%), Gaps = 15/481 (3%)

Query: 23  EGLTYNDFLLLPGYIDFTAEEVDLTSPLTKKILLKAPLVSTPMDTVTEADMAISMALCGG 82
           EGLT++D LL+P Y +    EVD+++ LTK+I L  P+VS  MDTVTEA +AI++A  GG
Sbjct: 10  EGLTFDDVLLVPQYSEVLPHEVDVSTYLTKRIKLNIPIVSAAMDTVTEARLAIALAREGG 69

Query: 83  IGIIHHNCTPEYQANEVHKVKKYKHGFIRDPVCMGPENTVADVLEAKKKNGFTGYPITQN 142
           IGIIH N   + QA EV KVKK + G I +PV + P+  V + L+   K   +G P+   
Sbjct: 70  IGIIHRNLPIKKQAEEVEKVKKSESGMIINPVTVKPDTRVKEALDIMAKYKISGVPVVDE 129

Query: 143 GKLGGRLIGIVTSRDIDF-REGDPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKG 201
            +   +LIGI+T+RD+ F +  D    + E MT  N +ITA  G+TL +A  I  K K  
Sbjct: 130 ER---KLIGILTNRDLRFIKPEDYSKPVSEFMTKEN-LITAPEGITLDEAEEIFRKYKIE 185

Query: 202 KLPIINNDGELVALIARTDLKKARSYPNASKDSNKQLLVGAAIGTRDTDRERLKLLVNNG 261
           KLPI++ +G++  LI   D+ K + YPNA KD   +L VGAA+GT +   +R+  LV  G
Sbjct: 186 KLPIVDKEGKIKGLITIKDIVKRKKYPNACKDELGRLRVGAAVGTGEETLDRVAALVEAG 245

Query: 262 VDVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVVTRMQAKNLIDAGVDALRVGMGS 321
           VDVIV+D++ G+S   ++ ++ IK  +PE+ V+ GNV T    K LI+AG DA++VG+G 
Sbjct: 246 VDVIVVDTAHGHSKRVLETVEKIKANFPEVDVIAGNVATAEGTKALIEAGADAVKVGVGP 305

Query: 322 GSICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQSVGHIIKSLALGASTVMMG 381
           GSIC T+ V   G PQ TA+ + AS AR +++P+IADGGI+  G I+K+LA GAS VM+G
Sbjct: 306 GSICTTRIVAGVGVPQLTAIMEAASAAREYDIPIIADGGIRYSGDIVKALAAGASAVMLG 365

Query: 382 SLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMESKDGKGSAMSRYFHKESDKHRVAQGV 441
           +LLAGT EAPGE  +  G   K YRGMGSL AM S+     +  RY  ++ +K  V +G+
Sbjct: 366 NLLAGTEEAPGETIYYQGRAYKVYRGMGSLGAMSSR----LSSDRYGQEKMEKF-VPEGI 420

Query: 442 SGSIVDKGSVLRFLPYLQAGMQHSCQDLGARSVSVLREMSHSGDLRFMKRTYSAQLEGNV 501
            G +  KG +   +  L  G++     +GAR++  L+E +     +F++ T++   E +V
Sbjct: 421 EGRVPYKGKLADVVYQLVGGLRSGMGYVGARNIKELQEKA-----KFVRITWAGYRESHV 475

Query: 502 H 502
           H
Sbjct: 476 H 476


>UniRef50_Q39F71 Cluster: IMP dehydrogenase; n=31;
           Proteobacteria|Rep: IMP dehydrogenase - Burkholderia sp.
           (strain 383) (Burkholderia cepacia (strain ATCC 17760/
           NCIB 9086 / R18194))
          Length = 486

 Score =  357 bits (878), Expect = 4e-97
 Identities = 191/483 (39%), Positives = 294/483 (60%), Gaps = 19/483 (3%)

Query: 23  EGLTYNDFLLLPGYIDFTAEEVDLTSPLTKKILLKAPLVSTPMDTVTEADMAISMALCGG 82
           + LT++D LL+P + D    +  L + LT+ I L  PLVS  MDTVTE  +AI+MA  GG
Sbjct: 6   KALTFDDVLLVPAFSDVLPRDTSLKTKLTRNISLNMPLVSAAMDTVTEGRLAIAMAQQGG 65

Query: 83  IGIIHHNCTPEYQANEVHKVKKYKHGFIRDPVCMGPENTVADVLEAKKKNGFTGYPITQN 142
           +GI+H N TP  QA EV KVK+++ G +RDP+ + P+  V DV+   +++G +G+P+ + 
Sbjct: 66  VGIVHKNLTPAEQAREVAKVKRFESGVVRDPITVPPQMKVRDVIALSRQHGISGFPVVE- 124

Query: 143 GKLGGRLIGIVTSRDIDFREGDPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGK 202
              G +L+GIVT+RD+ F E      +K +MTP   ++T + G  L +A  ++   +  +
Sbjct: 125 ---GPQLVGIVTNRDLRF-ETRLDEPVKSIMTPRERLVTVKEGTPLAEAKALMHSHRLER 180

Query: 203 LPIINNDGELVALIARTDLKKARSYPNASKDSNKQLLVGAAIGTRDTDRERLKLLVNNGV 262
           + ++N+  EL  L+   D+ K   +P+A KD + +L  GAA+G    + ER++LLV  GV
Sbjct: 181 VLVVNDAFELRGLMTVKDITKQTEHPDACKDEHGKLRAGAAVGVGPDNEERVELLVQAGV 240

Query: 263 DVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVVTRMQAKNLIDAGVDALRVGMGSG 322
           DVIV+D++ G+S   ++ ++++K+ +P ++V+GGN+ T   AK L++ G DA++VG+G G
Sbjct: 241 DVIVVDTAHGHSKGVLERVRWVKQNFPHVEVIGGNIATAAAAKALVEYGADAVKVGIGPG 300

Query: 323 SICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQSVGHIIKSLALGASTVMMGS 382
           SIC T+ V   G PQ +A+  VA   +   VP IADGG++  G + K+LA GA+ VMMGS
Sbjct: 301 SICTTRIVAGVGVPQISAIANVAEALKGTGVPCIADGGVRFSGDVSKALAAGANAVMMGS 360

Query: 383 LLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMESKDGKGSAMSRYFHKES---DKHRVAQ 439
           + AGT EAPG+ F   G + K YRGMGS+ AM  KDG   A  RYF   S   DK  V +
Sbjct: 361 MFAGTEEAPGDVFLYQGRQYKSYRGMGSVGAM--KDG---AADRYFQDNSANIDK-LVPE 414

Query: 440 GVSGSIVDKGSVLRFLPYLQAGMQHSCQDLGARSVSVLREMSHSGDLRFMKRTYSAQLEG 499
           G+ G +  KGSV   L  L  G++ S    G +++  L + +      F++ T +   E 
Sbjct: 415 GIEGRVAYKGSVNAILFQLVGGVRASMGYCGCKTIDELHDKA-----EFVQITAAGMRES 469

Query: 500 NVH 502
           +VH
Sbjct: 470 HVH 472


>UniRef50_Q49729 Cluster: Inosine-5'-monophosphate dehydrogenase;
           n=581; cellular organisms|Rep: Inosine-5'-monophosphate
           dehydrogenase - Mycobacterium leprae
          Length = 529

 Score =  346 bits (851), Expect = 7e-94
 Identities = 193/460 (41%), Positives = 278/460 (60%), Gaps = 9/460 (1%)

Query: 24  GLTYNDFLLLPGYIDFTAEEVDLTSPLTKKILLKAPLVSTPMDTVTEADMAISMALCGGI 83
           GLT++D LLLP   D      D++S LTKKI LK PLVS+ MDTVTEA MAI+MA  GG+
Sbjct: 44  GLTFDDVLLLPAASDVVPATADISSQLTKKIRLKVPLVSSAMDTVTEARMAIAMARAGGM 103

Query: 84  GIIHHNCTPEYQANEVHKVKKYKHGFIRDPVCMGPENTVADVLEAKKKNGFTGYPITQNG 143
           G++H N     QA +V  VK+ + G + DPV   P+NT+A V     +   +G P+  + 
Sbjct: 104 GVLHRNLPVGEQAGQVETVKRSEAGMVTDPVTCRPDNTLAQVGALCARFRISGLPVVDDS 163

Query: 144 KLGGRLIGIVTSRDIDFREGDPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKL 203
              G L GI+T+RD+ F E D    + EVMT    +ITA  GV+   A  +L ++K  KL
Sbjct: 164 ---GALAGIITNRDMRF-EVDQSKQVAEVMTK-TPLITAAEGVSADAALGLLRRNKIEKL 218

Query: 204 PIINNDGELVALIARTDLKKARSYPNASKDSNKQLLVGAAIGTRDTDRERLKLLVNNGVD 263
           P+++  G L  LI   D  K   +P A+KD++ +LLVGAA+G       R  +LV+ GVD
Sbjct: 219 PVVDGHGRLTGLITVKDFVKTEQHPLATKDNDGRLLVGAAVGVGGDAWVRAMMLVDAGVD 278

Query: 264 VIVLDSSQGNSTYQIKMIKYIK-ETYPEIQVVGGNVVTRMQAKNLIDAGVDALRVGMGSG 322
           V+++D++  ++   + M+  +K E    +QV+GGNV TR  A  L++AG DA++VG+G G
Sbjct: 279 VLIVDTAHAHNRLVLDMVGKLKVEIGDRVQVIGGNVATRSAAAALVEAGADAVKVGVGPG 338

Query: 323 SICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQSVGHIIKSLALGASTVMMGS 382
           S C T+ V   G PQ TA+ +  +      VPVIADGG+Q  G I K+LA GAST M+GS
Sbjct: 339 STCTTRVVAGVGAPQITAILEAVAACGPAGVPVIADGGLQYSGDIAKALAAGASTTMLGS 398

Query: 383 LLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMESKDG-KGSAMSRYFHKE--SDKHRVAQ 439
           LLAGT+EAPGE  F +G + K YRGMGSL AM+ + G K  +  RYF  +  S+   V +
Sbjct: 399 LLAGTAEAPGELIFVNGKQFKSYRGMGSLGAMQGRGGDKSYSKDRYFADDALSEDKLVPE 458

Query: 440 GVSGSIVDKGSVLRFLPYLQAGMQHSCQDLGARSVSVLRE 479
           G+ G +  +G +   +  L  G++ +    G+ ++ VL++
Sbjct: 459 GIEGRVPFRGPLSSVIHQLVGGLRAAMGYTGSPTIEVLQQ 498


>UniRef50_Q9RT87 Cluster: Inosine-5`-monophosphate dehydrogenase;
           n=14; cellular organisms|Rep: Inosine-5`-monophosphate
           dehydrogenase - Deinococcus radiodurans
          Length = 500

 Score =  331 bits (814), Expect = 2e-89
 Identities = 194/483 (40%), Positives = 290/483 (60%), Gaps = 20/483 (4%)

Query: 23  EGLTYNDFLLLPGYIDFTAEEVDLTSPLTKKILLKAPLVSTPMDTVTEADMAISMALCGG 82
           EG+T++D LL P +      EVD+++ LT+++ L  P VS  MDTVTE +MAI+MA  GG
Sbjct: 25  EGITFDDVLLQPRHSQVLPHEVDVSAQLTRRVRLNIPFVSAAMDTVTETNMAIAMAREGG 84

Query: 83  IGIIHHNCTPEYQANEVHKVKKYKHGFIRDPVCMGPENTVADVLEAKKKNGFTGYPITQN 142
           IG++H N + + QA  + KVK+ + G I DP+ + P  TV D      +   +G P+T  
Sbjct: 85  IGVVHKNMSIDAQAEMIRKVKRSESGMIVDPITLPPSATVRDADRLMGEYRISGVPVTAP 144

Query: 143 GKLGGRLIGIVTSRDIDFREGDPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGK 202
               G+L+GI+T+RD+ F + D  + L +VMT    ++T  +G  L+ A  + + ++  K
Sbjct: 145 D---GKLLGIITNRDMRFID-DLDVPLGDVMTR-EHLVTVPVGTDLEQARELFKLNRIEK 199

Query: 203 LPIINNDGE-LVALIARTDLKKARSYPNASKDSNKQLLVGAAIGTRDTDRERLKLLVNNG 261
           L +   +GE L  LI   D++K+  YPNA+KD   +L V AAIG      +R   LV  G
Sbjct: 200 LLV--TEGEYLRGLITIKDIEKSVKYPNAAKDDLGRLRVAAAIGVSADLMDRAGALVQAG 257

Query: 262 VDVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVVTRMQAKNLIDAGVDALRVGMGS 321
            DV+VLDS+ G+S   +  +  +KE + ++ V+ GNV TR  A++LI AG DA++VG+G 
Sbjct: 258 ADVLVLDSAHGHSQGILNALSRVKEQF-DVDVIAGNVATRSGARDLILAGADAVKVGIGP 316

Query: 322 GSICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQSVGHIIKSLALGASTVMMG 381
           GSIC T+ V   G PQ TA+++ ++ A    +PVIADGGI+  G + K++A GAS VMMG
Sbjct: 317 GSICTTRVVTGVGVPQVTAIFEASAAAMEAGIPVIADGGIKQTGDVPKAIAAGASVVMMG 376

Query: 382 SLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMESKDGKGSAMSRYFHKESDKHRVAQGV 441
           S+LAGT EAPGE    DG R K YRGMGSL AM+    +GSA  RYF   S K  V +G+
Sbjct: 377 SMLAGTDEAPGETILRDGRRYKSYRGMGSLGAMD----QGSA-DRYFQGGSRKF-VPEGI 430

Query: 442 SGSIVDKGSVLRFLPYLQAGMQHSCQDLGARSVSVLREMSHSGDLRFMKRTYSAQLEGNV 501
            G I  +G+    +     G++ S    GA  ++ LR+ +     +F++ T ++ +E + 
Sbjct: 431 EGIIAYRGTAGEVIYQFVGGLKSSMGYCGAPDLTTLRDTA-----QFVRITGASLVESHP 485

Query: 502 HGL 504
           HG+
Sbjct: 486 HGV 488


>UniRef50_A7DPR0 Cluster: Inosine-5'-monophosphate dehydrogenase;
           n=1; Candidatus Nitrosopumilus maritimus SCM1|Rep:
           Inosine-5'-monophosphate dehydrogenase - Candidatus
           Nitrosopumilus maritimus SCM1
          Length = 476

 Score =  331 bits (814), Expect = 2e-89
 Identities = 183/459 (39%), Positives = 273/459 (59%), Gaps = 12/459 (2%)

Query: 23  EGLTYNDFLLLPGYIDFTAE-EVDLTSPLTKKILLKAPLVSTPMDTVTEADMAISMALCG 81
           EGLT++D LL+P Y D T+  + DLT+ L++ I +  P VS  MDTVTE+ MA++MA  G
Sbjct: 5   EGLTFDDVLLVPKYSDITSRSQTDLTTKLSRNITINIPFVSANMDTVTESSMAVAMARAG 64

Query: 82  GIGIIHHNCTPEYQANEVHKVKKYKHGFIRDPVCMGPENTVADVLEAKKKNGFTGYPITQ 141
           GIGIIH   T + QANEV KVK+     I +P  +  + ++ D L+  +    +G  +  
Sbjct: 65  GIGIIHRFLTIQEQANEVLKVKRSGSVMIENPYSISSDKSIQDALDYAEDKEISGLLVVD 124

Query: 142 NGKLGGRLIGIVTSRDIDFREGDPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKG 201
           +     +L+GIVT RD+ F   +   ++ +VMT   D++TA+ GV+L +A  IL K +  
Sbjct: 125 SNS---KLVGIVTERDLLFAGSNG--TIADVMT--KDVVTAKPGVSLDEAKDILHKHRIE 177

Query: 202 KLPIINNDGELVALIARTDLKKARSYPNASKDSNKQLLVGAAIGTRDTDRERLKLLVNNG 261
           KLPI+++ G +  LI   D+     YPNASKD   + LVGAA+G +    ER + L+N G
Sbjct: 178 KLPIVDDSGIIQGLITSKDITNNTDYPNASKDKKGRPLVGAAVGVKGDFLERSESLLNAG 237

Query: 262 VDVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVVTRMQAKNLIDAGVDALRVGMGS 321
            DV+V+D + G+S   I  ++ IK+ +P+ +++ GN+ T   A++LI AGVDA++VG+GS
Sbjct: 238 ADVLVVDIAHGHSENAISTVRNIKKAFPDCELIAGNIATAQGAEDLIKAGVDAVKVGVGS 297

Query: 322 GSICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQSVGHIIKSLALGASTVMMG 381
           GSICIT+ +   G PQ TAV   A       +P+I+DGG ++ G   K+LA GAS+VM+G
Sbjct: 298 GSICITRVITGSGVPQLTAVMDCAKIGNDHGIPIISDGGTRTSGDATKALAAGASSVMVG 357

Query: 382 SLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMESKDGKGSAMSRYFHKESD-KHRVAQG 440
           S+L GT E+PG     +G R K YRGM SL A     G+ S  +     E D    VA+G
Sbjct: 358 SMLGGTDESPGTVLTKNGKRFKVYRGMASLAA---SIGRKSKETGSISLEDDLNDYVAEG 414

Query: 441 VSGSIVDKGSVLRFLPYLQAGMQHSCQDLGARSVSVLRE 479
           V   +  KG+V   L  L  G++      GA ++  +++
Sbjct: 415 VEAMVPYKGTVTDILKQLAGGVRSGLSYCGAHTIPQMQQ 453


>UniRef50_P0ADG9 Cluster: Inosine-5'-monophosphate dehydrogenase;
           n=14; Gammaproteobacteria|Rep: Inosine-5'-monophosphate
           dehydrogenase - Shigella flexneri
          Length = 488

 Score =  325 bits (799), Expect = 1e-87
 Identities = 184/458 (40%), Positives = 267/458 (58%), Gaps = 12/458 (2%)

Query: 23  EGLTYNDFLLLPGYIDFTAEEVDLTSPLTKKILLKAPLVSTPMDTVTEADMAISMALCGG 82
           E LT++D LL+P +        DL++ LTK I L  P++S  MDTVTEA +AI++A  GG
Sbjct: 7   EALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTEARLAIALAQEGG 66

Query: 83  IGIIHHNCTPEYQANEVHKVKKYKHGFIRDPVCMGPENTVADVLEAKKKNGFTGYPITQN 142
           IG IH N + E QA EV +VKK++ G + DP  + P  T+ +V E  ++NGF GYP+   
Sbjct: 67  IGFIHKNMSIERQAEEVRRVKKHESGVVTDPQTVLPTTTLREVKELTERNGFAGYPVVTE 126

Query: 143 GKLGGRLIGIVTSRDIDFREGDPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGK 202
                 L+GI+T RD+ F   D +  +   MTP   ++T + G   +     + + +  K
Sbjct: 127 EN---ELVGIITGRDVRFVT-DLNQPVSVYMTPKERLVTVREGEAREVVLAKMHEKRVEK 182

Query: 203 LPIINNDGELVALIARTDLKKARSYPNASKDSNKQLLVGAAIGTRDTDRERLKLLVNNGV 262
             +++++  L+ +I   D +KA   PNA KD   +L VGAA+G    + ER+  LV  GV
Sbjct: 183 ALVVDDEFHLIGMITVKDFQKAERKPNACKDEQGRLRVGAAVGAGAGNEERVDALVAAGV 242

Query: 263 DVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVVTRMQAKNLIDAGVDALRVGMGSG 322
           DV+++DSS G+S   ++ I+  +  YP++Q++GGNV T   A+ L +AG  A++VG+G G
Sbjct: 243 DVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATAAGARALAEAGCSAVKVGIGPG 302

Query: 323 SICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQSVGHIIKSLALGASTVMMGS 382
           SIC T+ V   G PQ TAV           +PVIADGGI+  G I K++A GAS VM+GS
Sbjct: 303 SICTTRIVTGVGVPQITAVADAVEALEGTGIPVIADGGIRFSGDIAKAIAAGASAVMVGS 362

Query: 383 LLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMESKDGKGSAMSRYFHKESDKHR-VAQGV 441
           +LAGT E+PGE     G   K YRGMGSL AM     KGS+  RYF  ++   + V +G+
Sbjct: 363 MLAGTEESPGEIELYQGRSYKSYRGMGSLGAM----SKGSS-DRYFQSDNAADKLVPEGI 417

Query: 442 SGSIVDKGSVLRFLPYLQAGMQHSCQDL-GARSVSVLR 478
            G +  KG  L+ + + Q G   SC  L G  ++  LR
Sbjct: 418 EGRVAYKGR-LKEIIHQQMGGLRSCMGLTGCGTIDELR 454


>UniRef50_Q59011 Cluster: Inosine-5'-monophosphate dehydrogenase;
           n=15; Euryarchaeota|Rep: Inosine-5'-monophosphate
           dehydrogenase - Methanococcus jannaschii
          Length = 496

 Score =  313 bits (768), Expect = 8e-84
 Identities = 181/486 (37%), Positives = 283/486 (58%), Gaps = 23/486 (4%)

Query: 26  TYNDFLLLPGYIDFTAEEVDLTSPLTKKILLKAPLVSTPMDTVTEADMAISMALCGGIGI 85
           T++D LL+P       ++ D+++ L   + L  P+VS  MDTVTE +MAI++A  GG+G+
Sbjct: 14  TFDDVLLVPNASWVEPKDTDVSTDLAG-LKLNIPIVSAAMDTVTEKEMAIALARLGGLGV 72

Query: 86  IHHNCTPEYQANEVHKVKKYKHGFIRDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKL 145
           IH N + E Q ++V  VKK     I+D + + P++TV + +   +    +G P+  N   
Sbjct: 73  IHRNMSIEEQVHQVQAVKKADEVVIKDVITVSPDDTVGEAINVMETYSISGLPVVDNED- 131

Query: 146 GGRLIGIVTSRDIDFREGDPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPI 205
             +L+GI+T RD+   E D    +K+VMT   D++ A+  V  ++A  ++  ++  +LPI
Sbjct: 132 --KLVGIITHRDVKAIE-DKTKKVKDVMT--KDVVCAKEDVEEEEALELMYANRVERLPI 186

Query: 206 INNDGELVALIARTDLKKARSYPNASKDSNKQLLVGAAIGTRDTDRERLKLLVNNGVDVI 265
           ++++  L+ +I   D+ K R YP A++D   +LLV AA G  D   ER K L+   VD I
Sbjct: 187 VDDENRLIGIITLRDILKRRKYPQAARDKKGRLLVAAACGPHDF--ERAKALIEAEVDAI 244

Query: 266 VLDSSQGNSTYQIKMIKYIKETYP--EIQVVGGNVVTRMQAKNLIDAGVDALRVGMGSGS 323
            +D +  ++   ++ +K  KE     +I+++ GN+ T+  A++LI AG D L+VG+G GS
Sbjct: 245 AIDCAHAHNMRVVENVKKFKEMLEGTDIKLIVGNIATKEAAEDLIKAGADVLKVGIGPGS 304

Query: 324 ICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQSVGHIIKSLALGASTVMMGSL 383
           IC T+ V   G PQ TAV +VA  A+  NVP+IADGGI+  G I K++A GA  VM+GSL
Sbjct: 305 ICTTRVVAGVGVPQLTAVAEVADVAKEHNVPIIADGGIRYSGDIAKAIAAGADAVMLGSL 364

Query: 384 LAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMESKDGKGSAMSRYFHKESDKHR-----VA 438
           LAGT EAPG+    +G + K+YRGMGSL AM    G G+   RYF   +  H      V 
Sbjct: 365 LAGTDEAPGQLMVINGRKYKQYRGMGSLGAMTG--GVGAGADRYFQAPAKSHMKHVKLVP 422

Query: 439 QGVSGSIVDKGSVLRFLPYLQAGMQHSCQDLGARSVSVLREMSHSGDLRFMKRTYSAQLE 498
           +GV G++  KG V   +  L  G++ S    GA+++  ++E +     RF+  T S Q+E
Sbjct: 423 EGVEGAVPYKGPVSEVVFQLIGGLRASMGYCGAKNLKEMQEKA-----RFVIITPSGQVE 477

Query: 499 GNVHGL 504
            + H +
Sbjct: 478 SHPHDI 483


>UniRef50_A6DTA2 Cluster: Inosine-5'-monophosphate dehydrogenase;
           n=2; Lentisphaerae|Rep: Inosine-5'-monophosphate
           dehydrogenase - Lentisphaera araneosa HTCC2155
          Length = 500

 Score =  305 bits (750), Expect = 1e-81
 Identities = 192/464 (41%), Positives = 264/464 (56%), Gaps = 19/464 (4%)

Query: 23  EGLTYNDFLLLPGYIDFTAEEVDLTSPLTKKILLKAPLVSTPMDTVTEADMAISMALCGG 82
           +GLT++D  L+  Y DF  EE  + S  ++ I L  P VS  MDTVT   MAI++A  GG
Sbjct: 17  QGLTFDDVTLVTQYADFLPEETSIKSKFSRNIGLNIPFVSAAMDTVTGPSMAIAIARLGG 76

Query: 83  IGIIHHNCTPEYQANEVHKVKKYKHGFIRDPVCMGPENTVADVLEAK--KKNGFTGYPIT 140
           IG+IH N      A  V KVK + +G I+DPV      TV ++L  K  K+  F+G+PI 
Sbjct: 77  IGVIHKNMDIALHAEAVKKVKLHSNGLIQDPVSFQESQTVEELLNYKDEKRLPFSGFPIV 136

Query: 141 QNGKLGGRLIGIVTSRDIDFREGDPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKK 200
                 GR+ GI+T++D+ F   D  L LK+VMT  + ++TA  G TL+DA  I+   K 
Sbjct: 137 D---ANGRVAGILTAKDLKFC-NDSRLKLKDVMT--SSILTANEGTTLEDAYKIMIDKKI 190

Query: 201 GKLPIINNDGELVALIARTDLKKARSYPN--ASKDSNKQLLVGAAIGTRDTDRERLKLLV 258
           GKLP++  +G L  L +  D+    +  +   + DS  QL   AAI   D    R + L+
Sbjct: 191 GKLPLLCENGSLAGLYSFHDVNALITGTSKLENLDSKYQLRCAAAISPYDFG--RAEALI 248

Query: 259 NNGVDVIVLDSSQGNSTYQIKMIKYIKETY-PEIQVVGGNVVTRMQAKNLIDAGVDALRV 317
           N GVD IV+D++ G+S   I+ +K +K      + V+ GNV T + AK L DAG DA++V
Sbjct: 249 NAGVDAIVIDTAHGHSKGVIETVKELKAGMGSSVDVIAGNVGTAVGAKALADAGADAVKV 308

Query: 318 GMGSGSICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQSVGHIIKSLALGAST 377
           G+G GSIC T+ V   G PQ TAVY+ AS A   +VP+IADGGI+  G + K++  GAS+
Sbjct: 309 GIGPGSICTTRVVCGVGVPQITAVYE-ASRAVPSDVPIIADGGIKQSGDVPKAITSGASS 367

Query: 378 VMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMESKDGKGSAMSRYFH--KESDKH 435
           VMMG LLA T E+PGE     G R   YRGMGSLEAM  K GKGS   RY     E    
Sbjct: 368 VMMGGLLAATEESPGEKIMMQGRRFVVYRGMGSLEAM--KSGKGS-RERYSQGDVEDSSQ 424

Query: 436 RVAQGVSGSIVDKGSVLRFLPYLQAGMQHSCQDLGARSVSVLRE 479
            + QGV G +  +G+    L      ++ S    GA++V  L++
Sbjct: 425 LIPQGVEGRVPYRGTAGSVLHQFAGSLKFSLGYCGAKTVPELQQ 468


>UniRef50_Q4QEB3 Cluster: Inosine-5'-monophosphate dehydrogenase;
           n=7; cellular organisms|Rep: Inosine-5'-monophosphate
           dehydrogenase - Leishmania major
          Length = 553

 Score =  294 bits (722), Expect = 3e-78
 Identities = 176/490 (35%), Positives = 274/490 (55%), Gaps = 20/490 (4%)

Query: 23  EGLTYNDFLLLPGYIDFTAEE-VDLTSPLTKKILLKAPLVSTPMDTVTEADMAISMALCG 81
           EGLTY+D LL+P      + + V+ ++ L++ I LK P+V++ MDTV E   A++MA  G
Sbjct: 73  EGLTYDDVLLIPQRSPVRSRKAVNTSTRLSRNIHLKIPIVASNMDTVCEDKTAVTMAREG 132

Query: 82  GIGIIHHNCTPEYQANEVHKVKKYKHGFIRDPVCMGPENTVADVLEAKKKNGFTGYP--- 138
           GIGI+H  C+ E Q   V KVK+ +   I DP  + P  T A+ LE    +G  G     
Sbjct: 133 GIGILHRFCSIEEQCAMVRKVKRAQSFLIEDPRMILPSATKAEALEELNWSGRKGGVSCL 192

Query: 139 ITQNGKLGGRLIGIVTSRDIDFREGDPHLSLKEVMTPINDMITA-QLGVTLQDANYILEK 197
           +  +     RL G++T  D+ F  G     ++ +MTP++ M+ +    +TL++A  ++  
Sbjct: 193 MVVDDLTSRRLCGVLTKSDLTFATGSA--LVETLMTPVSRMVVSTNTAITLEEAREVMRT 250

Query: 198 SKKGKLPIINNDGELVALIARTDLKKARSYPNASKDSNKQLLVGAAIGTRDTDRERLKLL 257
            +   +P++   GEL+ LI R+D+ K     NA+ DS  +L+VGAAIG +  D ER   L
Sbjct: 251 KRTKNIPLLGPKGELLYLITRSDILKLTGNLNATLDSRGRLIVGAAIGVKKEDHERAAAL 310

Query: 258 VNNGVDVIVLDSSQGNSTYQIKMIKYIKET--YPEIQVVGGNVVTRMQAKNLIDAGVDAL 315
           V+ G DV+V+D + G+S   I M+K +K      ++ ++ GN+ T   A++LIDAG D L
Sbjct: 311 VDAGADVLVVDIAHGHSDLCIDMVKALKVNPLTNKVDIIAGNIATAEAAQDLIDAGADGL 370

Query: 316 RVGMGSGSICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQSVGHIIKSLALGA 375
           ++G+G GSICIT+ V   G PQ ++V   A  A+   VP IADGGI++ G I K++A GA
Sbjct: 371 KIGVGPGSICITRLVAGSGVPQLSSVMDCARVAKKHGVPCIADGGIKTAGDICKAIAAGA 430

Query: 376 STVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMESKDGKGSAMSR-YFHKESDK 434
            TVM+G++LAGT EAPG     DG ++K  RGM    A  SK  +   +    FH     
Sbjct: 431 DTVMLGNMLAGTDEAPGRVLVKDGKKVKIIRGMAGFGANISKAEREQRLDEDVFH----- 485

Query: 435 HRVAQGVSGSIVDKGSVLRFLPYLQAGMQHSCQDLGARSVSVLREMSHSGDLRFMKRTYS 494
             V +GV GS+  KG +   L  L  G++      G+ S++ +++ +     RF++ + +
Sbjct: 486 DLVPEGVEGSVPCKGPLAPILKQLVGGLRSGISYCGSHSIADMQQRA-----RFVRMSGA 540

Query: 495 AQLEGNVHGL 504
              E   H +
Sbjct: 541 GLRESGSHDI 550


>UniRef50_Q4PBE7 Cluster: Putative uncharacterized protein; n=2;
           Fungi/Metazoa group|Rep: Putative uncharacterized
           protein - Ustilago maydis (Smut fungus)
          Length = 247

 Score =  281 bits (690), Expect = 2e-74
 Identities = 155/253 (61%), Positives = 181/253 (71%), Gaps = 28/253 (11%)

Query: 280 MIKYIKETYPEIQVVGGNVVTRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQAT 339
           MI++IK+TYP+I VV GNVVTR QA +LI AG DALRVGMGSGSICITQEVMA G PQ T
Sbjct: 1   MIQWIKQTYPQIDVVAGNVVTREQAASLIAAGADALRVGMGSGSICITQEVMAVGRPQGT 60

Query: 340 AVYQVASYARHFNVPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEAPGEYFFSDG 399
           AV+        F VPVIADGGI +VGHI K+LALGAS VMMG LLAGT+E+PG+YF+ DG
Sbjct: 61  AVHA-------FGVPVIADGGISNVGHIAKALALGASAVMMGGLLAGTTESPGDYFYRDG 113

Query: 400 VRLKKYRGMGSLEAMESK--------DGKGSAMS------------RYFHKESDKHRVAQ 439
            RLK YRGMGS+EAME +         GKG+A +            RYF  ESD  +VAQ
Sbjct: 114 KRLKGYRGMGSIEAMEHQKKGKIAGATGKGAAKADKVATDENAATQRYF-SESDAVKVAQ 172

Query: 440 GVSGSIVDKGSVLRFLPYLQAGMQHSCQDLGARSVSVLREMSHSGDLRFMKRTYSAQLEG 499
           GV+G++ DKGSV +FLPYL  G+QHS QD+G   +  LR    SG +RF  RT SAQ+EG
Sbjct: 173 GVAGAVQDKGSVKKFLPYLYTGLQHSLQDMGVPHLYQLRSAVASGQVRFELRTASAQVEG 232

Query: 500 NVHGLFSYEKRLF 512
            VHGL SYEKRLF
Sbjct: 233 GVHGLHSYEKRLF 245


>UniRef50_Q0DN24 Cluster: Os03g0780500 protein; n=7;
           Magnoliophyta|Rep: Os03g0780500 protein - Oryza sativa
           subsp. japonica (Rice)
          Length = 220

 Score =  265 bits (650), Expect = 2e-69
 Identities = 136/225 (60%), Positives = 168/225 (74%), Gaps = 6/225 (2%)

Query: 288 YPEIQVVGGNVVTRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASY 347
           YPE+ ++GGNVVT  QA+NL+ +GVD LRVGMGSGSIC TQEV A G  QATAVY+VASY
Sbjct: 2   YPEVDLIGGNVVTIAQAQNLVASGVDGLRVGMGSGSICTTQEVCAVGRGQATAVYKVASY 61

Query: 348 ARHFNVPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEAPGEYFFSDGVRLKKYRG 407
           A+  NVPVIADGGI + GHI+K+L+LGASTVMMGS LAG+ EAPG Y + DG R+KKYRG
Sbjct: 62  AKDHNVPVIADGGISNSGHIVKALSLGASTVMMGSFLAGSHEAPGTYEYKDGHRVKKYRG 121

Query: 408 MGSLEAMESKDGKGSAMSRYFHKESDKHRVAQGVSGSIVDKGSVLRFLPYLQAGMQHSCQ 467
           MGSLEAM     KGS  +RY   ++ K +VAQGV G++ DKGSVLRF+PY    ++   Q
Sbjct: 122 MGSLEAMT----KGSD-ARYL-GDTLKLKVAQGVVGAVADKGSVLRFIPYTMQAVKQGFQ 175

Query: 468 DLGARSVSVLREMSHSGDLRFMKRTYSAQLEGNVHGLFSYEKRLF 512
           DLGA S+    E+  S  ++   RT +AQ+EG +HGL SYEK+ F
Sbjct: 176 DLGASSLQSAHELLRSETIKLEVRTGAAQVEGGIHGLVSYEKKAF 220


>UniRef50_A7CYS7 Cluster: Malate dehydrogenase precursor; n=1;
           Opitutaceae bacterium TAV2|Rep: Malate dehydrogenase
           precursor - Opitutaceae bacterium TAV2
          Length = 564

 Score =  256 bits (626), Expect = 1e-66
 Identities = 167/479 (34%), Positives = 264/479 (55%), Gaps = 35/479 (7%)

Query: 24  GLTYNDFLLLPGYIDFTAEEVDLTSPLTKKILLKAPLVSTPMDTVTEADMAISMALCGGI 83
           GLT++D  L   Y D   ++ D ++ L+  + L  P++S+ MDTVTE  MAI+MAL GG+
Sbjct: 69  GLTFDDVSLATLYSDILPKDADTSTSLSDALKLSIPIISSDMDTVTEERMAIAMALNGGL 128

Query: 84  GIIHHNCTPEYQANEVHKVKKYKHGFIRDPVCMGPENTVADVLEA--KKKNGFTGYPITQ 141
           G+IH+N     Q   V +VK++ HG I+DP+ + P   VADVL+    K+  F  +P+  
Sbjct: 129 GLIHYNMPARDQVKAVARVKRHIHGLIQDPITVTPNQYVADVLDLVEHKRYDFRTFPVVD 188

Query: 142 NGKLGGRLIGIVTSRDIDFREGDPHLSLKEVMTPINDMITA---QLG---VTLQDANYIL 195
                G+L+G+++   +  RE     ++ E M+P  ++ T    QL    +   DA +  
Sbjct: 189 EH---GKLVGLLSGSSV--RERYKGKTVAEAMSPRGEIQTLHERQLQPDPIKAADA-FFT 242

Query: 196 EKSKKGKLPIINNDGELVALIARTD----LKKARSYPNASKDSNKQLLVGAAI------- 244
           E     K+ +++++  L  L+  +D    L+++RS    ++D   +L+VGAAI       
Sbjct: 243 EHIGIHKMLVVDDNDRLRGLVTFSDIDSILQESRSRRKPARDHAFRLVVGAAIAPVRHPD 302

Query: 245 GTRDTDR--ERLKLLVNNGVDVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVVTRM 302
           GT D D+    +  LV+  +D + + ++ G++T    M+K ++  +P + ++ GNV +  
Sbjct: 303 GTLDRDKIISHVGHLVDESIDAVAVSTAHGHTTGVGDMVKLVRAAFPNLTIIAGNVTSGA 362

Query: 303 QAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQ 362
             + L D G +A++VG G GSIC T+ V   G PQ TA+Y  +  AR  N+ +IADGGI 
Sbjct: 363 GVEFLADCGANAIKVGQGPGSICTTRIVAGVGIPQLTALYVASRAARGKNIKIIADGGIT 422

Query: 363 SVGHIIKSLALGASTVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMESKDGKGS 422
             G I+K+L LG   V++G LLAG  EAPGE    +G   K+YRGMGSL AM +    GS
Sbjct: 423 KSGDIVKALTLG-DAVILGGLLAGCREAPGEIIDINGKLYKQYRGMGSLSAMNA----GS 477

Query: 423 AMSRYFHKESDKHR--VAQGVSGSIVDKGSVLRFLPYLQAGMQHSCQDLGARSVSVLRE 479
           A +RY H ++D  R   A+G+       GS    L  L  G+Q     LG++ +  LR+
Sbjct: 478 A-ARYGHDKTDTTRKLTAEGIEALKEVSGSADDVLATLVGGVQSGMGYLGSKDLPTLRQ 535


>UniRef50_Q8EW89 Cluster: Inosine-5'-monophosphate dehydrogenase;
           n=1; Mycoplasma penetrans|Rep: Inosine-5'-monophosphate
           dehydrogenase - Mycoplasma penetrans
          Length = 483

 Score =  252 bits (617), Expect = 2e-65
 Identities = 153/481 (31%), Positives = 269/481 (55%), Gaps = 17/481 (3%)

Query: 25  LTYNDFLLLPGYIDFTAEEVDLTSPLTKKILLKAPLVSTPMDTVTEADMAISMALCGGIG 84
           LT++D LL P Y +   +E D+ + L+ +  +K P++S  MDTVTE +MA +M+L GGIG
Sbjct: 11  LTFDDVLLRPQYSEVLPKETDVRTTLSSRFQMKIPIMSASMDTVTEIEMAYNMSLNGGIG 70

Query: 85  IIHHNCTPEYQANEVHKVKKYKHGFIRDPVCMGPENTVADVLEAKKKNGFTGYPITQNGK 144
           +IH N +   Q+N + ++K  K+G   + +     N ++ + E K  + +    I     
Sbjct: 71  VIHKNLSHSQQSNMIKQIKHIKNGLYYNIMAFESSNKISMIKE-KVFDEYLDDCIFVT-- 127

Query: 145 LGGRLIGIVTSRDIDFREGDPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLP 204
           + G ++ IV+  D++ ++ D + +L+ +      +I A+   +L++   I++++K   +P
Sbjct: 128 VNGSIVNIVSKEDLENKKIDSNSTLESIGR--KKIIFAKDSSSLEEILKIMDENKLDFMP 185

Query: 205 IINNDGE-LVALIARTDLKKARSYPNASKDSNKQLLVGAAIGTRDTDRERLKLLVNNGVD 263
           I++     ++A+  R  L    +  +   DS ++  V  AIG  +   ER KLL+  GVD
Sbjct: 186 IVSETTNGIIAVAKRKWLVPYLNSDDPLIDSKERPKVCGAIGVTEDSIERAKLLIAAGVD 245

Query: 264 VIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVVTRMQAKNLIDAGVDALRVGMGSGS 323
            I++D + G+S   I++ + IK+ +P++ ++ GNVVT     +L  AG DA+++G+G G+
Sbjct: 246 AIIIDCAHGHSKKVIELTREIKKLFPKLFLIVGNVVTANGVNDLYKAGADAVKIGVGPGA 305

Query: 324 ICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQSVGHIIKSLALGASTVMMGSL 383
           IC T+ V   G PQ +A+ +    A+  N+P+IADGGI++ G ++K+LA GA  VM+GSL
Sbjct: 306 ICTTRTVSGVGIPQFSAILECYEEAKKLNIPIIADGGIKNSGDMVKALAAGADAVMLGSL 365

Query: 384 LAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMESKDGKGSAMSRYFHKESDKHRVAQGVSG 443
           LAG  E+P      +    K+YRGMGS+ AM     K  +  RY  ++  K  VA+GV G
Sbjct: 366 LAGCDESPSVKVMHNNKMYKQYRGMGSIAAM-----KAGSSDRY-GQDGIKKLVAEGVEG 419

Query: 444 SIVDKGSVLRFLPYLQAGMQHSCQDLGARSVSVLREMSHSGDLRFMKRTYSAQLEGNVHG 503
            +   G V   L  L  G++     +GA++++ L+  +      F+++T     E + H 
Sbjct: 420 LMPYIGPVKESLYQLVGGLKSGMGYVGAKTLTDLKNKA-----EFVEQTGIGLKESSTHS 474

Query: 504 L 504
           +
Sbjct: 475 I 475


>UniRef50_P50097 Cluster: Inosine-5'-monophosphate dehydrogenase;
           n=28; cellular organisms|Rep: Inosine-5'-monophosphate
           dehydrogenase - Tritrichomonas foetus (Trichomonas
           foetus)
          Length = 503

 Score =  240 bits (587), Expect = 7e-62
 Identities = 152/404 (37%), Positives = 223/404 (55%), Gaps = 17/404 (4%)

Query: 26  TYNDFLLLPGY--IDFTAEEVDLTSPLTK-------KILLKAPLVSTPMDTVTEADMAIS 76
           T+N++LL+PG   +D     V+L++PL K       +I LK PLVS  M +V+   MAI+
Sbjct: 11  TFNEYLLIPGLSTVDCIPSNVNLSTPLVKFQKGQQSEINLKIPLVSAIMQSVSGEKMAIA 70

Query: 77  MALCGGIGIIHHNCTPEYQANEVHKVKKYKHGFIRDPVCMGPENTVADVLEAKKKNGFTG 136
           +A  GGI  I  + + E QA  VH VK +K GF+     + P+ T ADVL   ++     
Sbjct: 71  LAREGGISFIFGSQSIESQAAMVHAVKNFKAGFVVSDSNVKPDQTFADVLAISQRTTHNT 130

Query: 137 YPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLKEVMTPINDMITAQLGVTLQDANYILE 196
             +T +G   G L+G+VT RD           + ++MTP + ++TA     L +AN I+ 
Sbjct: 131 VAVTDDGTPHGVLLGLVTQRDYPIDLTQTETKVSDMMTPFSKLVTAHQDTKLSEANKIIW 190

Query: 197 KSKKGKLPIINNDGELVALIARTDLKKARSYPNASKDSNKQLLVGAAIGTRDTDRERLKL 256
           + K   LPII++D  L  ++ R D  +++   N   DS K+ LVGA I TRD  RER+  
Sbjct: 191 EKKLNALPIIDDDQHLRYIVFRKDYDRSQVCHNELVDSQKRYLVGAGINTRDF-RERVPA 249

Query: 257 LVNNGVDVIVLDSSQGNSTYQIKMIKYIKETY-PEIQVVGGNVVTRMQAKNLIDAGVDAL 315
           LV  G DV+ +DSS G S +Q   I +I+E Y  +++V  GN+V     + L DAG D +
Sbjct: 250 LVEAGADVLCIDSSDGFSEWQKITIGWIREKYGDKVKVGAGNIVDGEGFRYLADAGADFI 309

Query: 316 RVGMGSGSICITQEVMACGCPQATAVYQ-VASYARHFN-----VPVIADGGIQSVGHIIK 369
           ++G+G GSICIT+E    G  QATAV   VA   ++F      +PV +DGGI    H+  
Sbjct: 310 KIGIGGGSICITREQKGIGRGQATAVIDVVAERNKYFEETGIYIPVCSDGGIVYDYHMTL 369

Query: 370 SLALGASTVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEA 413
           +LA+GA  +M+G   A   E+P      +G  +K+Y G GS  A
Sbjct: 370 ALAMGADFIMLGRYFARFEESPTRKVTINGSVMKEYWGEGSSRA 413


>UniRef50_Q08MB8 Cluster: Inosine-5'-monophosphate dehydrogenase;
           n=1; Stigmatella aurantiaca DW4/3-1|Rep:
           Inosine-5'-monophosphate dehydrogenase - Stigmatella
           aurantiaca DW4/3-1
          Length = 344

 Score =  223 bits (545), Expect = 9e-57
 Identities = 125/293 (42%), Positives = 188/293 (64%), Gaps = 9/293 (3%)

Query: 25  LTYNDFLLLPGYIDFTAEEVDLTSPLTKKILLKAPLVSTPMDTVTEADMAISMALCGGIG 84
           LT++D LLLP        +V+L++ LT+++ L  PL+S  MDTVTE+  AI+MA  GGIG
Sbjct: 46  LTFDDVLLLPAESSVVPRDVELSTRLTRQLRLHIPLLSAAMDTVTESRSAIAMAQEGGIG 105

Query: 85  IIHHNCTPEYQANEVHKVKKYKHGFIRDPVCMGPENTVADVLEAKKKNGFTGYPITQNGK 144
           +IH N TPE QA EV KVKK++ G + DPV + P   +A  LE  + +G +G P+TQ   
Sbjct: 106 VIHKNMTPEQQALEVLKVKKFESGMVVDPVTIEPGAPLARALELMRHHGVSGVPVTQ--- 162

Query: 145 LGGRLIGIVTSRDIDFREGDPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLP 204
            G RL+GIVTSRD+ F E +    +++VMT    +IT + G+T  +A  +L + +  KL 
Sbjct: 163 -GRRLVGIVTSRDVRF-ETNLTQKVEQVMT--RKLITGREGITQPEAQALLHQHRIEKLL 218

Query: 205 IINNDGELVALIARTDLKKARSYPNASKDSNKQLLVGAAIGTRDTDRE-RLKLLVNNGVD 263
           I+N + EL  LI   D++K R++PNA+KD+  +LL  AA+G    DRE R+  LV  GVD
Sbjct: 219 IVNEEFELKGLITIKDIEKRRTHPNAAKDAKGRLLCAAAVGV-SADREARIDALVKAGVD 277

Query: 264 VIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVVTRMQAKNLIDAGVDALR 316
           VIV+D++ G+S + I  ++  ++ +   +++ GNV T    + LI+AGVDA++
Sbjct: 278 VIVVDTAHGHSRFVIDGVRDTRKNFKGFELIAGNVATAEGTRALIEAGVDAVK 330


>UniRef50_UPI00015B43E8 Cluster: PREDICTED: similar to GA14756-PA;
           n=1; Nasonia vitripennis|Rep: PREDICTED: similar to
           GA14756-PA - Nasonia vitripennis
          Length = 240

 Score =  218 bits (533), Expect = 2e-55
 Identities = 98/128 (76%), Positives = 115/128 (89%)

Query: 385 AGTSEAPGEYFFSDGVRLKKYRGMGSLEAMESKDGKGSAMSRYFHKESDKHRVAQGVSGS 444
           AGTSEAPGEYFFSDGVRLKKYRGMGS+EAM+ KD  GSAM RYFH E DK +VAQGVSGS
Sbjct: 113 AGTSEAPGEYFFSDGVRLKKYRGMGSIEAMDRKDASGSAMDRYFHNEMDKLKVAQGVSGS 172

Query: 445 IVDKGSVLRFLPYLQAGMQHSCQDLGARSVSVLREMSHSGDLRFMKRTYSAQLEGNVHGL 504
           IVDKG+VL+FLPYLQ G++H CQD+GA+S++ L++M ++G+LRF KRT+SAQ EGNVHGL
Sbjct: 173 IVDKGTVLKFLPYLQCGIKHGCQDIGAKSITALKQMMYNGELRFEKRTHSAQQEGNVHGL 232

Query: 505 FSYEKRLF 512
           FSYEKRLF
Sbjct: 233 FSYEKRLF 240



 Score =  171 bits (417), Expect = 3e-41
 Identities = 77/91 (84%), Positives = 85/91 (93%)

Query: 11  DGLSAEDTFANSEGLTYNDFLLLPGYIDFTAEEVDLTSPLTKKILLKAPLVSTPMDTVTE 70
           DGL+A   FAN +GLTYNDF++LPGYIDFTA+EVDL SPLTKKI LKAPLVS+PMDTVTE
Sbjct: 20  DGLTAAQLFANGDGLTYNDFIILPGYIDFTADEVDLHSPLTKKITLKAPLVSSPMDTVTE 79

Query: 71  ADMAISMALCGGIGIIHHNCTPEYQANEVHK 101
           +DMAI+MALCGGIGIIHHNCTPEYQANEVHK
Sbjct: 80  SDMAIAMALCGGIGIIHHNCTPEYQANEVHK 110


>UniRef50_P49058 Cluster: Inosine-5'-monophosphate dehydrogenase;
           n=7; cellular organisms|Rep: Inosine-5'-monophosphate
           dehydrogenase - Borrelia burgdorferi (Lyme disease
           spirochete)
          Length = 404

 Score =  205 bits (500), Expect = 2e-51
 Identities = 113/282 (40%), Positives = 169/282 (59%), Gaps = 12/282 (4%)

Query: 227 YPNASKDSNKQLLVGAAIGTRDTDRERLKLLVNNGVDVIVLDSSQGNSTYQIKMIKYIKE 286
           +PNA KD N +L VGAA+       ER++ LV   VD++V+DS+ G+ST  I++IK IK 
Sbjct: 131 FPNACKDLNNKLRVGAAVSIDIDTIERVEELVKAHVDILVIDSAHGHSTRIIELIKKIKT 190

Query: 287 TYPEIQVVGGNVVTRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVAS 346
            YP + ++ GN+VT+  A +LI  G D L+VG+G GSIC T+ V   G PQ TA+  V  
Sbjct: 191 KYPNLDLIAGNIVTKEAALDLISVGADCLKVGIGPGSICTTRIVAGVGVPQITAICDVYE 250

Query: 347 YARHFNVPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEAPGEYFFSDGVRLKKYR 406
              + N+ +IADGGI+  G ++K++A GA +VM+G+L AGT E+P E    +G + K Y 
Sbjct: 251 ACNNTNICIIADGGIRFSGDVVKAIAAGADSVMIGNLFAGTKESPSEEIIYNGKKFKSYV 310

Query: 407 GMGSLEAMESKDGKGSAMSRYFHKESD--KHRVAQGVSGSIVDKGSVLRFLPYLQAGMQH 464
           GMGS+ AM     K  + SRYF  E++  K  V +G+ G +   G +   L  L+ G+  
Sbjct: 311 GMGSISAM-----KRGSKSRYFQLENNEPKKLVPEGIEGMVPYSGKLKDILTQLKGGLMS 365

Query: 465 SCQDLGARSVSVLREMSHSGDLRFMKRTYSAQLEGNVHGLFS 506
               LGA ++S L+  S     +F+K ++S+  E + H +FS
Sbjct: 366 GMGYLGAATISDLKINS-----KFVKISHSSLKESHPHDVFS 402



 Score = 81.4 bits (192), Expect = 5e-14
 Identities = 42/84 (50%), Positives = 53/84 (63%)

Query: 23  EGLTYNDFLLLPGYIDFTAEEVDLTSPLTKKILLKAPLVSTPMDTVTEADMAISMALCGG 82
           E LT++D  L+P        EV L + LTK I L  P +S+ MDTVTE+ MAI++A  GG
Sbjct: 8   EALTFDDVSLIPRKSSVLPSEVSLKTQLTKNISLNIPFLSSAMDTVTESQMAIAIAKEGG 67

Query: 83  IGIIHHNCTPEYQANEVHKVKKYK 106
           IGIIH N + E Q  E+ KVK YK
Sbjct: 68  IGIIHKNMSIEAQRKEIEKVKTYK 91


>UniRef50_Q74LZ0 Cluster: Inosine-5-monophosphate dehydrogenase;
           n=20; Bacteria|Rep: Inosine-5-monophosphate
           dehydrogenase - Lactobacillus johnsonii
          Length = 384

 Score =  189 bits (461), Expect = 1e-46
 Identities = 102/299 (34%), Positives = 165/299 (55%), Gaps = 5/299 (1%)

Query: 187 TLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKARSY----PNASKDSNKQLLVGA 242
           T+ + N  +  ++ G L +I+ +  +   +      K ++     P+ + D   +LL  A
Sbjct: 55  TVTEGNMAIAMAENGGLGVIHKNLSIEVQVEEVKKAKGKTVDPNLPHPAVDDQGRLLAAA 114

Query: 243 AIGTRDTDRERLKLLVNNGVDVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVVTRM 302
           A+G      ER + L+  G D IV+D++ G+S   ++ IK I+E +P   ++ GNV T  
Sbjct: 115 AVGVTSDTFERAESLLEAGADAIVIDTAHGHSAGVLRKIKEIREHFPNATLIAGNVATGE 174

Query: 303 QAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQ 362
               L DAGVD ++VG+G GSIC T+ V   G PQ TA+Y  AS A+ +   +IADGGI+
Sbjct: 175 GTAALFDAGVDVVKVGIGPGSICTTRIVAGVGVPQITAIYDAASVAQKYGKKIIADGGIK 234

Query: 363 SVGHIIKSLALGASTVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMESKDGKGS 422
             G ++K+LA G + VM+GS+ +GT+EAPG  F ++G + K YRGMG++ AM  + G   
Sbjct: 235 YSGDVVKALAAGGNAVMLGSMFSGTTEAPGTIFTNEGKQFKSYRGMGAVGAMSQQHGSSD 294

Query: 423 AMSRYFHKESDKHRVAQGVSGSIVDKGSVLRFLPYLQAGMQHSCQDLGARSVSVLREMS 481
              +    E++K  V +GV   +  KG V   +  +  G++     +GA ++  L E S
Sbjct: 295 RYFQGGVNEANK-LVPEGVEALVPYKGDVSNIIYQIDGGLRAGMGYVGAGTIKELIENS 352



 Score = 76.6 bits (180), Expect = 1e-12
 Identities = 41/88 (46%), Positives = 53/88 (60%), Gaps = 1/88 (1%)

Query: 16  EDTFANSEGLTYNDFLLLPGYIDFTAEEVDLTSPLTKKILLKAPLVSTPMDTVTEADMAI 75
           E  FA  +GLT++D LL+P        EV L + L   + L  PL+S  MDTVTE +MAI
Sbjct: 5   ETKFAK-KGLTFDDVLLIPAESHVLPNEVKLDTKLAPNLQLHIPLISAGMDTVTEGNMAI 63

Query: 76  SMALCGGIGIIHHNCTPEYQANEVHKVK 103
           +MA  GG+G+IH N + E Q  EV K K
Sbjct: 64  AMAENGGLGVIHKNLSIEVQVEEVKKAK 91


>UniRef50_P65172 Cluster: Uncharacterized oxidoreductase
           Rv1843c/MT1891; n=42; Bacteria|Rep: Uncharacterized
           oxidoreductase Rv1843c/MT1891 - Mycobacterium
           tuberculosis
          Length = 479

 Score =  170 bits (413), Expect = 9e-41
 Identities = 130/462 (28%), Positives = 227/462 (49%), Gaps = 15/462 (3%)

Query: 25  LTYNDFLLLPGYIDFTAE-EVDLTSPLTKKILLKAPLVSTPMDTVTEADMAISMALCGGI 83
           LTYND  ++P   +  +  +VDL++       +  P+V   M  V    MA ++A  GGI
Sbjct: 14  LTYNDVFIVPNRSEVASRFDVDLSTADGSGTTI--PVVVANMTAVAGRRMAETVARRGGI 71

Query: 84  GIIHHNCTPEYQANEVHKVKKYKHGFIRDPVCMGPENTVADVLEAKKKNGFTGYPITQNG 143
            I+  +  P     +     K +   +  PV + P+++V+D +    K    G  +    
Sbjct: 72  VILPQDL-PIPAVKQTVAFVKSRDLVLDTPVTLAPDDSVSDAMALIHKRAH-GVAVVI-- 127

Query: 144 KLGGRLIGIVTSRDIDFREGDPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKL 203
            L GR IG+V  R+      D    ++++   + D +TA  G   +    +LE +     
Sbjct: 128 -LEGRPIGLV--RESSCLGVDRFTRVRDIA--VTDYVTAPAGTEPRKIFDLLEHAPVDVA 182

Query: 204 PIINNDGELVALIARTDLKKARSYPNASKDSNKQLLVGAAIGTRDTDRERLKLLVNNGVD 263
            + + DG L  +++RT   +A  Y  A+ DS  +L +GAA+G       + + L   GVD
Sbjct: 183 VLTDADGTLAGVLSRTGAIRAGIYTPAT-DSAGRLRIGAAVGINGDVGAKARALAEAGVD 241

Query: 264 VIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVVTRMQAKNLIDAGVDALRVGMGSGS 323
           V+V+D++ G+    +  IK +      + +  GNVV+    ++L+ AG + ++VG+G G+
Sbjct: 242 VLVIDTAHGHQVKTLDAIKAVSALDLGLPLAAGNVVSAEGTRDLLKAGANVVKVGVGPGA 301

Query: 324 ICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQSVGHIIKSLALGASTVMMGSL 383
           +C T+ +   G PQ +AV + AS AR     + ADGGI+    +  +LA GAS VM+GS 
Sbjct: 302 MCTTRMMTGVGRPQFSAVLECASAARQLGGHIWADGGIRHPRDVALALAAGASNVMIGSW 361

Query: 384 LAGTSEAPGEYFFS-DGVRLKKYRGMGSLEAMESKDGKGSAMSRYFHKESDKHRVAQGVS 442
            AGT E+PG+     D    K+  GM S  A+ ++ G  +   R   K   +  ++    
Sbjct: 362 FAGTYESPGDLMRDRDDQPYKESYGMASKRAVVARTGADNPFDR-ARKALFEEGISTSRM 420

Query: 443 GSIVDKGSVLRFLPYLQAGMQHSCQDLGARSVSVLREMSHSG 484
           G   D+G V   + ++ +G++ +C  +GA +++ L E +  G
Sbjct: 421 GLDPDRGGVEDLIDHITSGVRSTCTYVGASNLAELHERAVVG 462


>UniRef50_A3H9U2 Cluster: IMP dehydrogenase; n=1; Caldivirga
           maquilingensis IC-167|Rep: IMP dehydrogenase -
           Caldivirga maquilingensis IC-167
          Length = 491

 Score =  167 bits (407), Expect = 5e-40
 Identities = 139/486 (28%), Positives = 225/486 (46%), Gaps = 37/486 (7%)

Query: 25  LTYNDFLLLPGYIDFTAEEVDLTSPLTKKILLKAPLVSTPMDTVTEADMAISMALCGGIG 84
           +T+ND +LLPG        +D ++ +++ + +  PLVS+PMDTVTE  +AI++A  GG+G
Sbjct: 33  VTFNDVVLLPGKATLDPISIDTSTKVSRSVSINIPLVSSPMDTVTEDALAIALARLGGVG 92

Query: 85  IIHHNCTPEYQANEVHKVKKYKHGFIRDPVCMGPENTVADVLEAKKKNGFTGYPITQNGK 144
           +IH N T   + N V  VK     +   P  + P  +  + +   ++      PI     
Sbjct: 93  VIHRNMTINDEVNAVKAVKD-ASPYPVIPFSLNPLMSSEEAMAELRRLNLDTLPIVDE-- 149

Query: 145 LGGRLIGIVTSRDIDFREGDPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLP 204
             GR+IG +    +        L+ K VM P+        G +  +   I+ ++    + 
Sbjct: 150 --GRVIGYIRRSRLLTGGRLIELAEKPVMAPV--------GSSGDELVKIMRENGTDTVA 199

Query: 205 IINNDGELVALIARTDLKKARSYPNASKDSNKQLLVGAAIGTRDTDRERLKLLVNNGVDV 264
           +++ D   + + +  DL     +  A+ D   +L+VGAA+   D +R    + V+   D 
Sbjct: 200 LVDKDNVFIGIASYYDLNYKPPFKPAT-DGEGRLIVGAAVSPFDVER---AVKVSKYADF 255

Query: 265 IVLDSSQ-GNSTYQIKMIKYIKETYPEIQVVGGNVVTRMQAKNLIDA--GVDALRVGMGS 321
           +V+D +   N      + K +KET   + V+ GN+ T   A + I     +   RVG+ S
Sbjct: 256 LVVDVAHVDNENALTALAKLVKET--PVDVIVGNLGTYDGAVDAITRVDPIGGFRVGIAS 313

Query: 322 GSICITQEVMACGCPQATAVYQVASYARHF---NVPVIADGGIQSVGHIIKSLALGASTV 378
           GSIC T  V     P   AV QVA  A  +   + P+IADGGI+  G ++K++A GA   
Sbjct: 314 GSICSTGVVTGVAAPTLWAVAQVADAALDYGLGSTPIIADGGIREPGDVVKAMAAGAWAA 373

Query: 379 MMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMESKDGKGSAMSRYFHKESDKHRVA 438
           MMG + A  +E+P           K YRGM S    E    +  AM RY  K  +   + 
Sbjct: 374 MMGRVFAQATESPSPIIRVGNRLYKYYRGMAS----EGARARRFAMDRYAPKVKN---IE 426

Query: 439 QGVSGSIVDKGSVLRFLPYLQAGMQHSCQDLGARSVSVLREMSHSGDLRFMKRTYSAQLE 498
           +GV G +  +G +   +     G+Q +   +GA + +  R        RFM  T S + E
Sbjct: 427 EGVEGLVPYRGDLANIVREFVGGIQAALGYIGASNTAEARVKG-----RFMIVTESGRGE 481

Query: 499 GNVHGL 504
              H L
Sbjct: 482 VEPHDL 487


>UniRef50_Q6MM64 Cluster: Inosine-5-monophosphate dehydrogenase;
           n=1; Bdellovibrio bacteriovorus|Rep:
           Inosine-5-monophosphate dehydrogenase - Bdellovibrio
           bacteriovorus
          Length = 346

 Score =  164 bits (399), Expect = 4e-39
 Identities = 96/300 (32%), Positives = 168/300 (56%), Gaps = 23/300 (7%)

Query: 206 INNDGELVALIARTDLKKARSYPNASKDSNKQLLVGAAIGTRDTDRERLKLLVNNGVDVI 265
           +N  G +  L    D+++  +     K++  +++ G+ +G  +  + R K LV  GV++I
Sbjct: 67  MNQLGGMGILHRFLDIEEQAAQARRLKENGVKVISGS-VGVGEEFKTRAKALVEAGVNII 125

Query: 266 VLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVVTRMQAKNLIDAGVDALRVGMGSGSIC 325
            +D + G+S   ++ +K++K+ YP++ ++ GN+ T   A++LI+AG DA++VG+G GS+C
Sbjct: 126 TIDIAHGHSVQMMETMKWLKDQYPQVDLIAGNLATPDAARDLIEAGADAIKVGIGPGSMC 185

Query: 326 ITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQSVGHIIKSLALGASTVMMGSLLA 385
            T+ +  CG PQ TA+   A     + VPVIADGGI++ G ++K+ A GASTVM+GS+L+
Sbjct: 186 TTRIITGCGVPQLTAIGLCAEIGESYGVPVIADGGIRTSGDMVKAFAAGASTVMLGSMLS 245

Query: 386 GTSEAPGEYFFSDGVRLKKYRGMGSLEAMES-KDGKGSAMSRYFHKESDKHRVAQGVSGS 444
           GT E PGE    +G   K+YRGM S  A +S + G    M+             +G S  
Sbjct: 246 GTIETPGE--IKNG--KKQYRGMASRSAQDSWRGGVPEGMA------------PEGESTQ 289

Query: 445 IVDKGSVLRFLPYLQAGMQHSCQDLGARSVSVLREMSHSGDLRFMKRTYSAQLEGNVHGL 504
           +  KG V   +  +  G++     + A S++ +++ +      FM+ + +   E   HG+
Sbjct: 290 VTVKGHVKDVILEVTGGIRSGMSYINATSIAEIKDKA-----LFMEMSSNGIAESRAHGV 344



 Score = 66.9 bits (156), Expect = 1e-09
 Identities = 38/105 (36%), Positives = 58/105 (55%), Gaps = 1/105 (0%)

Query: 16  EDTFANSEGLTYNDFLLLPGYIDFTAE-EVDLTSPLTKKILLKAPLVSTPMDTVTEADMA 74
           +D     +GLT++D L++P   D  +  +  LTS +TK   ++ P+VS  MD VTE DMA
Sbjct: 5   KDIKNRGKGLTFDDVLIIPARSDVRSRRDPRLTSKVTKNFTIETPIVSANMDMVTEYDMA 64

Query: 75  ISMALCGGIGIIHHNCTPEYQANEVHKVKKYKHGFIRDPVCMGPE 119
            +M   GG+GI+H     E QA +  ++K+     I   V +G E
Sbjct: 65  FAMNQLGGMGILHRFLDIEEQAAQARRLKENGVKVISGSVGVGEE 109


>UniRef50_A1RZ33 Cluster: GMP reductase; n=1; Thermofilum pendens
           Hrk 5|Rep: GMP reductase - Thermofilum pendens (strain
           Hrk 5)
          Length = 349

 Score =  151 bits (367), Expect = 3e-35
 Identities = 103/273 (37%), Positives = 148/273 (54%), Gaps = 19/273 (6%)

Query: 232 KDSNKQLLVGAAIGTRDTDRERLKLLVNNGVDVIVLDSSQGNSTYQIKMIKYIKETYPEI 291
           K S + L VG A+G  D   ER+   ++ G  +IV+D++ G+S   ++  +       E 
Sbjct: 91  KISGENLPVGVAVGPFDD--ERVSKALDAGASIIVIDTAHGHSRNVLEATRRYAGMGAE- 147

Query: 292 QVVGGNVVTRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHF 351
            V+ GN+VT   A +LI AG  +LRVG+G G  C T+EV   G PQ +AV +VA  AR  
Sbjct: 148 -VMAGNIVTAEAALDLIGAGAVSLRVGVGPGHACTTREVAGVGYPQLSAVAKVADAARSH 206

Query: 352 NVPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSL 411
            V V+ADGGI+    I+K+LA GA  VM+G LLAG+ EAPG      G   K YRGMGS 
Sbjct: 207 GVSVVADGGIEKPADIVKALAAGADAVMLGYLLAGSDEAPGHVVVRGGECFKVYRGMGSR 266

Query: 412 EAMESKDGKGSAMSRYFHKESDKHRVAQGVSGSIVDKGSVLRFLPYLQAGMQHSCQDLGA 471
            A+ S    GS  +RY     +  RV +GV G +  +G V   + +L  G++     +GA
Sbjct: 267 GALRS----GS--TRY----GEFKRVPEGVEGLVPCRGPVEGVVEFLVNGLKQGMGYVGA 316

Query: 472 RSVSVLREMSHSGDLRFMKRTYSAQLEGNVHGL 504
           R++  LR  +      F++ T++   E    GL
Sbjct: 317 RNLEELRVKA-----EFVRLTHAGVRESGPRGL 344



 Score = 76.2 bits (179), Expect = 2e-12
 Identities = 37/88 (42%), Positives = 57/88 (64%), Gaps = 1/88 (1%)

Query: 16  EDTFANSE-GLTYNDFLLLPGYIDFTAEEVDLTSPLTKKILLKAPLVSTPMDTVTEADMA 74
           E+   NSE GL+++D LL+P Y D   +EVD+++ LTK +LLK P++S+PMDTVT  +MA
Sbjct: 5   EEKIKNSELGLSFDDVLLVPKYSDVRIDEVDVSTRLTKNLLLKIPIISSPMDTVTGFEMA 64

Query: 75  ISMALCGGIGIIHHNCTPEYQANEVHKV 102
             +   GG+G++  N   +     V K+
Sbjct: 65  RKLGELGGLGVLPRNIPLDAVVEYVKKI 92


>UniRef50_Q5V6J1 Cluster: Inosine-5'-monophosphate dehydrogenase;
           n=3; Halobacteriaceae|Rep: Inosine-5'-monophosphate
           dehydrogenase - Haloarcula marismortui (Halobacterium
           marismortui)
          Length = 369

 Score =  149 bits (360), Expect = 2e-34
 Identities = 83/240 (34%), Positives = 127/240 (52%), Gaps = 11/240 (4%)

Query: 240 VGAAIGTRDTDRERLKLLVNNGVDVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVV 299
           VGAA+G  +    R   ++  GVD +V+D + G+    +  ++ + + +P+  ++ GNV 
Sbjct: 93  VGAAVGINEDYVARSAAVITAGVDALVVDVAHGHLNRALDAVETLADEFPDADIIAGNVA 152

Query: 300 TRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFNVPVIADG 359
           T    ++L  AG D ++VG+G GS C T++V   G PQ TAV   A+ A   +V + ADG
Sbjct: 153 TPAGVEDLAAAGADCVKVGIGPGSHCTTRKVAGAGVPQLTAVDDCATAAEDLDVTICADG 212

Query: 360 GIQSVGHIIKSLALGASTVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMESKDG 419
           GI++ G  +K+L  GA TVM+GSL AGT EAPG     DG R K+ RGM +  A E +D 
Sbjct: 213 GIRTSGDAVKALMAGADTVMLGSLFAGTEEAPGVVVEVDGTRYKRSRGMATTAAAEDRDD 272

Query: 420 KGSAMSRYFHKESDKHRVAQGVSGSIVDKGSVLRFLPYLQAGMQHSCQDLGARSVSVLRE 479
           K + +S             +GV      KGSV        AG++      G  +++  R+
Sbjct: 273 KQNNVS-----------ADEGVEALTPYKGSVAAVAEEFCAGIRSGLSYCGGHTIAAARD 321



 Score = 76.6 bits (180), Expect = 1e-12
 Identities = 38/81 (46%), Positives = 54/81 (66%), Gaps = 3/81 (3%)

Query: 24  GLTYNDFLLLP--GYIDFTAEEVDLTSPLTKKILLKAPLVSTPMDTVTEADMAISMALCG 81
           GL+Y D LL+P    +D +  ++DL++PLT  + L  PLVS  MDTVTEA++AI +   G
Sbjct: 7   GLSYGDVLLVPKRSPVD-SRSDIDLSTPLTPTVELDTPLVSAAMDTVTEAELAIELGQSG 65

Query: 82  GIGIIHHNCTPEYQANEVHKV 102
           G G++H   TPE QA +V +V
Sbjct: 66  GFGVLHRFLTPEEQAEQVEQV 86


>UniRef50_Q1IAJ4 Cluster: Putative inosine-5'-monophosphate
           dehydrogenase; n=1; Pseudomonas entomophila L48|Rep:
           Putative inosine-5'-monophosphate dehydrogenase -
           Pseudomonas entomophila (strain L48)
          Length = 381

 Score =  142 bits (344), Expect = 2e-32
 Identities = 89/248 (35%), Positives = 127/248 (51%), Gaps = 5/248 (2%)

Query: 233 DSNKQLLVGAAIGTRDTDRERLKLLVNNGVDVIVLDSSQGNSTYQIKMIKYIKETYPEIQ 292
           DS  +L VG +IG  D   +R   L    VD + LD + G+ST+ I  I  +KE   +I 
Sbjct: 101 DSQGRLKVGGSIGIVDDYLQRAAGLAACDVDFLTLDIAHGHSTHAIAAIANVKERLGDIP 160

Query: 293 VVGGNVVTRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFN 352
           +V GNV T     +L  AG   ++VG+G GS+C T+ V   G PQ TA+ + A+ AR   
Sbjct: 161 IVAGNVATPEGVLDLAKAGASVIKVGIGPGSVCTTRSVTGAGVPQLTAILECAAAAREAG 220

Query: 353 VPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLE 412
           V +IADGGI+S G I+K+LA GA  VM+G +LAGT E+  +     G R K  RG  +  
Sbjct: 221 VSIIADGGIRSSGDIVKALAAGAHAVMLGRMLAGTDESAAQLLEVSGKRFKLTRGFVTFG 280

Query: 413 A-MESKDGKGSAMSRYFHKESDKHRVAQGVSGSIVDKGSVLRFLPYLQAGMQHSCQDLGA 471
             +E K  +G  ++    +E     V +G+       G +  +L  L  G+Q      GA
Sbjct: 281 TNLELKRLQGQKIT----EEQLLRYVPEGIEACFEYAGPLRAYLYQLIGGVQSGFSYCGA 336

Query: 472 RSVSVLRE 479
                L E
Sbjct: 337 SDYQQLLE 344



 Score = 48.8 bits (111), Expect = 3e-04
 Identities = 28/82 (34%), Positives = 42/82 (51%), Gaps = 1/82 (1%)

Query: 23  EGLTYNDFLLLPGYIDFTA-EEVDLTSPLTKKILLKAPLVSTPMDTVTEADMAISMALCG 81
           +G  ++D LL+P      + ++ D+   L     L  P++S      TE  MA+ MA  G
Sbjct: 4   KGYVFDDVLLVPKKTHLASRKDADIGVELKGLGRLSVPVISANTQWCTEDRMAMEMARMG 63

Query: 82  GIGIIHHNCTPEYQANEVHKVK 103
           G+GI+H  C+ E Q   VH VK
Sbjct: 64  GLGIVHRMCSIEDQVAFVHAVK 85


>UniRef50_Q2JC64 Cluster: GMP reductase; n=2; Bacteria|Rep: GMP
           reductase - Frankia sp. (strain CcI3)
          Length = 385

 Score =  140 bits (339), Expect = 8e-32
 Identities = 83/254 (32%), Positives = 134/254 (52%), Gaps = 6/254 (2%)

Query: 230 ASKDSNKQLLVGAAIGTRDTDRERLKLLVNNGVDVIVLDSSQGNSTYQIKMIKYIKETYP 289
           A+ D   +LLVGAA+GT+    +R  L+V +G D++++D + G+S   I  +  +   +P
Sbjct: 100 ATVDPVGRLLVGAAVGTKGDYLDRAALMVEHGADLLLVDVAHGHSDQVIDTVGKLHARHP 159

Query: 290 EIQVVGGNVVTRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYAR 349
            + +V GNV T     +L+DAG D ++VG+G G +C T+ V   G PQ TA+   A  A 
Sbjct: 160 RVPIVAGNVATAGGTNDLLDAGADVVKVGIGPGGVCTTRLVAGSGVPQLTAIIDCAHAAA 219

Query: 350 HFNVPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEA-PGEYFFSDGVRLKKYRGM 408
             +  VIADGG++  G + K+LA GA+ VM+GS LAG  E+  G     DG R +  RG 
Sbjct: 220 QRDATVIADGGVRQSGDLAKALAAGAAAVMLGSALAGADESEAGVVDLPDGSRYRCSRGF 279

Query: 409 GSL-EAMESKDGKGSAMSRYFHKESDKHRVAQGVSGSIVDKGSVLRFLPYLQAGMQHSCQ 467
            +L  A   +   G  ++R    +     + +GV  +    G V   +  L  G++ +  
Sbjct: 280 ATLGMANTLRAAAGGRLTR----DDVVGYIPEGVEMTFAPSGPVADTVYQLVGGLRSAMS 335

Query: 468 DLGARSVSVLREMS 481
             GA  ++  R ++
Sbjct: 336 YTGAADMAEFRRLA 349



 Score = 45.2 bits (102), Expect = 0.004
 Identities = 26/81 (32%), Positives = 40/81 (49%), Gaps = 1/81 (1%)

Query: 24  GLTYNDFLLLPGYIDFTAE-EVDLTSPLTKKILLKAPLVSTPMDTVTEADMAISMALCGG 82
           GL+++D LL+P      +  +VD T  L   + L  P++       T   MA ++A  GG
Sbjct: 11  GLSFDDVLLVPHRTRVRSRADVDTTVDLAPGVRLWVPVIGANTQWCTGGAMAAALARVGG 70

Query: 83  IGIIHHNCTPEYQANEVHKVK 103
           +G +H   T E QA  +  VK
Sbjct: 71  LGFVHRMQTVERQATHIASVK 91


>UniRef50_Q9P2T1 Cluster: GMP reductase 2; n=169; cellular
           organisms|Rep: GMP reductase 2 - Homo sapiens (Human)
          Length = 348

 Score =  124 bits (299), Expect = 6e-27
 Identities = 76/240 (31%), Positives = 128/240 (53%), Gaps = 13/240 (5%)

Query: 240 VGAAIGTRDTDRERLKLLVNN--GVDVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGN 297
           + A+ GT  +D E+L+ ++     V  I LD + G S + ++ +K +++ +P+  ++ GN
Sbjct: 99  LAASSGTGSSDFEQLEQILEAIPQVKYICLDVANGYSEHFVEFVKDVRKRFPQHTIMAGN 158

Query: 298 VVTRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFNVPVIA 357
           VVT    + LI +G D ++VG+G GS+C T++    G PQ +AV + A  A      +I+
Sbjct: 159 VVTGEMVEELILSGADIIKVGIGPGSVCTTRKKTGVGYPQLSAVMECADAAHGLKGHIIS 218

Query: 358 DGGIQSVGHIIKSLALGASTVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMESK 417
           DGG    G + K+   GA  VM+G +LAG SE+ GE    DG + K + GM S  AM+  
Sbjct: 219 DGGCSCPGDVAKAFGAGADFVMLGGMLAGHSESGGELIERDGKKYKLFYGMSSEMAMKKY 278

Query: 418 DGKGSAMSRYFHKESDKHRVAQGVSGSIVDKGSVLRFLPYLQAGMQHSCQDLGARSVSVL 477
            G G A          ++R ++G +  +  KG V   +  +  G++ +C  +GA  +  L
Sbjct: 279 AG-GVA----------EYRASEGKTVEVPFKGDVEHTIRDILGGIRSTCTYVGAAKLKEL 327


>UniRef50_P60565 Cluster: GMP reductase; n=111; root|Rep: GMP
           reductase - Lactobacillus johnsonii
          Length = 330

 Score =  121 bits (291), Expect = 5e-26
 Identities = 70/180 (38%), Positives = 99/180 (55%), Gaps = 7/180 (3%)

Query: 235 NKQLLVGAAIGTRDTDRERLKLLVNNGV--DVIVLDSSQGNSTYQIKMIKYIKETYPEIQ 292
           +K L    ++G +D++ + +  L    +  +   +D + G+S Y IKMIKYIKE  P+  
Sbjct: 88  DKGLFASISVGIKDSEYDFIDYLAKENIIPEYTTIDVAHGHSDYVIKMIKYIKEKLPDTF 147

Query: 293 VVGGNVVTRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCP--QATAVYQVASYARH 350
           +  GN+ T    + L +AG DA +VG+G G  CIT+     G    Q  A+   +  AR 
Sbjct: 148 LTAGNIATPEAVRELENAGADATKVGVGPGRACITKLKTGFGTGGWQLAALRMCSKAARK 207

Query: 351 FNVPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGS 410
              P+IADGGI+  G I KS+  GAS VM+GSL AG  E+PG     DG R K+Y G  S
Sbjct: 208 ---PLIADGGIRHNGDIAKSVRFGASMVMIGSLFAGHEESPGNLITIDGKRYKQYWGSAS 264


>UniRef50_Q9YBU2 Cluster: Inosine-5'-monophosphate dehydrogenase;
           n=1; Aeropyrum pernix|Rep: Inosine-5'-monophosphate
           dehydrogenase - Aeropyrum pernix
          Length = 433

 Score =  119 bits (287), Expect = 2e-25
 Identities = 106/348 (30%), Positives = 169/348 (48%), Gaps = 34/348 (9%)

Query: 150 IGIVTSRDIDFREGDPHLSLKEVMTPI--NDMITAQLGVTLQDANYILEKSKKGKLPIIN 207
           +G++  R++   E   H+S+ + ++P   +++   +L   L++ + ILE+   G   +  
Sbjct: 72  VGVI-HRNMPREEQARHVSMVKSVSPSPWSEVPRIRLPDGLENYSLILEELDAGAAVVFG 130

Query: 208 NDG-ELVALIARTD----LKKARSY--------PNASKDSNKQLLVGAAIGTRDTDRERL 254
           +DG +   ++ R D    L+KAR          P  + D   +L+VGAA+   D DR RL
Sbjct: 131 DDGIKGYLVLERPDAQLWLEKARYLSLYLTRIRPFPTIDGEGRLVVGAAVSPFDLDRARL 190

Query: 255 KLLVNNGVDVIVLDSSQGNSTYQIKMI-KYIKETYPEIQVVGGNVVTRMQAKNLIDAG-- 311
             L  +G D +V+D +  ++   +  + + +KE    I VV GN+ TR    + +     
Sbjct: 191 --LEKSGADFLVIDVAHLHNRNALSSLSRLVKEV--SIDVVAGNLGTREGVLDTLARAEE 246

Query: 312 VDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFN----VPVIADGGIQSVGHI 367
           V  LR+G+ SGSIC T EV     P  TAV               +P+IADGG+++ G  
Sbjct: 247 VAGLRMGISSGSICSTGEVAGAAVPTLTAVMNAVLALEELGLAGRIPIIADGGVRNAGDA 306

Query: 368 IKSLALGASTVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMESKDGKGSAMSRY 427
            K++  GAS VM G L AG  E+PG          K YRGM S  AME +     A+ RY
Sbjct: 307 AKAIIAGASAVMGGRLFAGADESPGPRIRVGDKLYKPYRGMASRGAMERR----FAVDRY 362

Query: 428 FHKESDKHRVAQGVSGSIVDKGSVLRFLPYLQAGMQHSCQDLGARSVS 475
             +      V +GV G +   G V++ L  L  G++ +    GA+ V+
Sbjct: 363 SRQAK---AVEEGVEGLVPYTGPVVKTLYELAEGLKAALGYAGAQDVT 407



 Score = 73.3 bits (172), Expect = 1e-11
 Identities = 35/79 (44%), Positives = 50/79 (63%)

Query: 25  LTYNDFLLLPGYIDFTAEEVDLTSPLTKKILLKAPLVSTPMDTVTEADMAISMALCGGIG 84
           LT++D  +LPG       +V+L+S +++ I +  PLVS+PMDTVTE  MA ++A  G +G
Sbjct: 14  LTFDDVAILPGLSTVEPHDVELSSRVSRSIFVSTPLVSSPMDTVTEWRMAAALARLGAVG 73

Query: 85  IIHHNCTPEYQANEVHKVK 103
           +IH N   E QA  V  VK
Sbjct: 74  VIHRNMPREEQARHVSMVK 92


>UniRef50_Q5ZRN7 Cluster: Inosine 5'-monophosphate dehydrogenase;
           n=4; Legionella pneumophila|Rep: Inosine
           5'-monophosphate dehydrogenase - Legionella pneumophila
           subsp. pneumophila (strain Philadelphia 1 /ATCC 33152 /
           DSM 7513)
          Length = 337

 Score =  116 bits (279), Expect = 1e-24
 Identities = 72/240 (30%), Positives = 123/240 (51%), Gaps = 16/240 (6%)

Query: 240 VGAAIGTRDTDRERLKLLVNNGVDVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVV 299
           V  ++G  + + +R + L + G D   +D +  ++ Y  K +K +++      ++ GNV 
Sbjct: 89  VFVSVGCTENELQRAEALRDAGADFFCVDVAHAHAKYVGKTLKSLRQLLGSRCIMAGNVA 148

Query: 300 TRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFNVPVIADG 359
           T   A  L   G D ++ G+G GS+C T+     G P  T +   +   R     ++ADG
Sbjct: 149 TYAGADYLASCGADIIKAGIGGGSVCSTRIKTGFGVPMLTCIQDCSRADR----SIVADG 204

Query: 360 GIQSVGHIIKSLALGASTVMMGSLLAGTSEAPGEYF-FSDGVRLKKYRGMGSLEAMESKD 418
           GI++ G I+K+LA GA  VM+G +LAG++  PGE F   DG ++K+YRGM S EA E+  
Sbjct: 205 GIKTSGDIVKALAFGADFVMIGGMLAGSAPTPGEVFQKDDGSKVKRYRGMASREAQEA-- 262

Query: 419 GKGSAMSRYFHKESDKHRVAQGVSGSIVDKGSVLRFLPYLQAGMQHSCQDLGARSVSVLR 478
                    F  +  + + A+GV+  +  K +    +  +  G++      GA S+S L+
Sbjct: 263 ---------FLGQMHEWKTAEGVATEVPFKENPDGIIADIIGGLRSGLTYAGADSISELQ 313



 Score = 50.4 bits (115), Expect = 1e-04
 Identities = 28/83 (33%), Positives = 44/83 (53%), Gaps = 2/83 (2%)

Query: 23  EGLTYNDFLLLPGYIDFTAEEVDLTSPLTK--KILLKAPLVSTPMDTVTEADMAISMALC 80
           + +T++D LL+P Y    +  V  T+   +  K+ L  P++S  MDT+TE++MA  M   
Sbjct: 4   QAITFDDVLLVPSYNHHESRRVVETTSTDRLGKLTLNLPVISANMDTITESNMANFMHSK 63

Query: 81  GGIGIIHHNCTPEYQANEVHKVK 103
           G +G +H   T E    E  K K
Sbjct: 64  GAMGALHRFMTIEENIQEFKKCK 86


>UniRef50_A4GHK1 Cluster: Guanosine monophosphate reductase; n=1;
           uncultured marine bacterium EB0_35D03|Rep: Guanosine
           monophosphate reductase - uncultured marine bacterium
           EB0_35D03
          Length = 366

 Score =  105 bits (251), Expect = 4e-21
 Identities = 76/281 (27%), Positives = 134/281 (47%), Gaps = 14/281 (4%)

Query: 205 IINNDGELVALIARTDLKKARSYPNASKDSNKQLLVGAAIGTRDTDRERLKLL---VNNG 261
           I++       L+    + +  +Y NA  D  ++  V  +IG  D D  + K +   V+ G
Sbjct: 72  ILSKQQIFTCLVKTLAVDELVNYFNAKNDFRREH-VAMSIGITDNDSAKFKEVYKQVDKG 130

Query: 262 -VDVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVVTRMQAKNLIDAGVDALRVGMG 320
            +  + +D + G S      ++  ++ YP + ++ GNVVT    + LI  G D ++VG+G
Sbjct: 131 NLKYVCIDVANGYSERFSNFVRKFRKQYPNVVIIAGNVVTGEMTEELILNGADIVKVGIG 190

Query: 321 SGSICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQSVGHIIKSLALGASTVMM 380
            GS+C T+     G PQ +AV + A  A      +IADGG  S G ++K+ A G+  VM+
Sbjct: 191 PGSVCTTRIQTGVGYPQLSAVIECADAAHGLGGHIIADGGCASPGDVVKAFAGGSDFVML 250

Query: 381 GSLLAGTSEAPGEY----FFSDGVRLKKYRGMGSLEAMESKDGKGSAMSRYFHKESDKHR 436
           G +LAG  E  G+     + +  V + + +       M S     +A  ++F    D +R
Sbjct: 251 GGMLAGHDEGGGKIITKEYITKEVDVTEEKSFIQFYGMSS----DAANVKHFGGLKD-YR 305

Query: 437 VAQGVSGSIVDKGSVLRFLPYLQAGMQHSCQDLGARSVSVL 477
            ++G    +  +G V   +  +  G++ SC   GA+ +  L
Sbjct: 306 SSEGREVLVPYRGEVSNTIQDILGGIRSSCTYAGAQRLKHL 346


>UniRef50_Q7NTY1 Cluster: GMP reductase; n=1; Chromobacterium
           violaceum|Rep: GMP reductase - Chromobacterium violaceum
          Length = 316

 Score =  101 bits (243), Expect = 3e-20
 Identities = 78/245 (31%), Positives = 116/245 (47%), Gaps = 23/245 (9%)

Query: 238 LLVGAAIGTRDTDRERLKLLVNNGV--DVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVG 295
           L    ++G  D   E+L  L   G+  + + LD +        +MIK+IK+ +P   ++G
Sbjct: 86  LFASISVGVNDDTYEQLDALKAAGLSPEYMTLDIANAWCVKAERMIKHIKQHFPNTFLIG 145

Query: 296 GNVVTRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFNVPV 355
           GNV T   A++L   G DA++ G+  G +CIT+       P  + V    +      +PV
Sbjct: 146 GNVATAEAARDLEAWGCDAIKAGIAGGRVCITKNKTGFHRPMVSTVRDCVAAV---TIPV 202

Query: 356 IADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAME 415
           IADGGI   G I K+L  GA+ VM GSL AG  E+ G+     G   K+Y G        
Sbjct: 203 IADGGIVEHGDIAKALVCGATMVMAGSLFAGYDESAGDIVEIAGKHYKEYFGSA------ 256

Query: 416 SKDGKGSAMSRYFHKESDKHRVAQGVSGSIVDKGSVLRFLPYLQAGMQHSCQDLGARSVS 475
           S+  KG+    Y + E  K  V          KGS+ + L  LQ  +Q S    G  +++
Sbjct: 257 SQFNKGA----YVNVEGKKILVEY--------KGSMGKLLRELQEDLQSSVSYAGGTTLA 304

Query: 476 VLREM 480
            LRE+
Sbjct: 305 ALREV 309


>UniRef50_Q4S0S1 Cluster: Chromosome undetermined SCAF14779, whole
           genome shotgun sequence; n=8; Eumetazoa|Rep: Chromosome
           undetermined SCAF14779, whole genome shotgun sequence -
           Tetraodon nigroviridis (Green puffer)
          Length = 271

 Score = 98.7 bits (235), Expect = 3e-19
 Identities = 64/190 (33%), Positives = 96/190 (50%), Gaps = 5/190 (2%)

Query: 288 YPEIQVVGGNVVTRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASY 347
           +PE  V  GNVVT    + LI AG D ++VG+G GS+C T++    G PQ +AV + A  
Sbjct: 70  HPEC-VKAGNVVTGEMVEELILAGADIIKVGIGPGSVCTTRKKTGVGYPQLSAVIECADA 128

Query: 348 ARHFNVPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEAPGEYFFSDGVRLKKYRG 407
           A      +I+DGG    G + K+   GA  VM+G +LAG SE+ G+     G + K + G
Sbjct: 129 AHGLGGHIISDGGCTCPGDVSKAFGAGADFVMLGGMLAGHSESGGDIIEKSGKKYKLFYG 188

Query: 408 MGSLEAMESKDGKGSAMSRYFHKESDKHRVAQGVSGSIVDKGSVLRFLPYLQAGMQHSCQ 467
           M S  AM    G G A    +   S     ++G +  +  KG V   +  +  G++ +C 
Sbjct: 189 MSSDTAMRKHAG-GVA---EYRSASASCGASEGKTVEVPYKGPVEVTIRDVLGGVRSTCT 244

Query: 468 DLGARSVSVL 477
            +GA  +  L
Sbjct: 245 YVGAGKLKEL 254


>UniRef50_Q4X988 Cluster: Putative uncharacterized protein; n=6;
           Plasmodium|Rep: Putative uncharacterized protein -
           Plasmodium chabaudi
          Length = 187

 Score = 97.5 bits (232), Expect = 7e-19
 Identities = 46/97 (47%), Positives = 69/97 (71%), Gaps = 1/97 (1%)

Query: 186 VTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKARSYPNASKDSNKQLLVGAAIG 245
           ++L DAN +L   KK  LPI+N++ EL+AL+ R D+ K + +P+ASK  NKQL+VGA+I 
Sbjct: 2   ISLSDANKVLCDEKK-ILPIVNDNYELIALVCRNDMHKNKIFPHASKRENKQLIVGASIS 60

Query: 246 TRDTDRERLKLLVNNGVDVIVLDSSQGNSTYQIKMIK 282
           TR++D E++  L  N +D+I +DSSQGNS   +  +K
Sbjct: 61  TRESDLEKVNKLAQNMIDIICIDSSQGNSVTSLSFMK 97


>UniRef50_Q4S0S8 Cluster: Chromosome undetermined SCAF14779, whole
           genome shotgun sequence; n=1; Tetraodon
           nigroviridis|Rep: Chromosome undetermined SCAF14779,
           whole genome shotgun sequence - Tetraodon nigroviridis
           (Green puffer)
          Length = 376

 Score = 97.1 bits (231), Expect = 1e-18
 Identities = 61/182 (33%), Positives = 92/182 (50%), Gaps = 4/182 (2%)

Query: 296 GNVVTRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFNVPV 355
           GNVVT    + LI AG D ++VG+G GS+C T++    G PQ +AV + A  A      +
Sbjct: 178 GNVVTGEMVEELILAGADIIKVGIGPGSVCTTRKKTGVGYPQLSAVIECADAAHGLGGHI 237

Query: 356 IADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAME 415
           I+DGG    G + K+   GA  VM+G +LAG SE+ G+     G + K + GM S  AM 
Sbjct: 238 ISDGGCTCPGDVSKAFGAGADFVMLGGMLAGHSESGGDIIEKSGKKYKLFYGMSSDTAMR 297

Query: 416 SKDGKGSAMSRYFHKESDKHRVAQGVSGSIVDKGSVLRFLPYLQAGMQHSCQDLGARSVS 475
              G G A    +   S     ++G +  +  KG V   +  +  G++ +C  +GA  + 
Sbjct: 298 KHAG-GVA---EYRSASASCGASEGKTVEVPYKGPVEVTIRDVLGGVRSTCTYVGAGKLK 353

Query: 476 VL 477
            L
Sbjct: 354 EL 355


>UniRef50_Q0PQW0 Cluster: Putative inosine-5'-monophosphate
           dehydrogenase; n=1; Endoriftia persephone
           'Hot96_1+Hot96_2'|Rep: Putative inosine-5'-monophosphate
           dehydrogenase - Endoriftia persephone 'Hot96_1+Hot96_2'
          Length = 173

 Score = 95.1 bits (226), Expect = 4e-18
 Identities = 46/86 (53%), Positives = 58/86 (67%)

Query: 308 IDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQSVGHI 367
           +DAG DA++VG+G GSIC T+ V   G PQ TAV  VA       VP+IADGG++  G I
Sbjct: 1   VDAGADAVKVGIGPGSICTTRIVAGVGVPQVTAVSNVAKQLEDSGVPLIADGGLRYSGDI 60

Query: 368 IKSLALGASTVMMGSLLAGTSEAPGE 393
            K LA GA +VM+G + AGT E+PGE
Sbjct: 61  AKVLASGAYSVMVGGMFAGTDESPGE 86


>UniRef50_Q4UGU3 Cluster: Gmp reductase, putative; n=3;
           Piroplasmida|Rep: Gmp reductase, putative - Theileria
           annulata
          Length = 330

 Score = 92.7 bits (220), Expect = 2e-17
 Identities = 61/181 (33%), Positives = 94/181 (51%), Gaps = 7/181 (3%)

Query: 238 LLVGAAIGTRDTDRERL-KLLVNNGV-DVIVLDSSQGNSTYQIKMIKYIKETYP-EIQVV 294
           L V  ++G ++   + + +L  NN V D I +D S G++     MI +I+  +  +  ++
Sbjct: 95  LFVSISVGVKEESYDVVTELKENNEVPDFITIDISHGHNQRVKGMIDHIRSCFGNKTFII 154

Query: 295 GGNVVTRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCP--QATAVYQVASYARHFN 352
            GNV T    +++   G +A++VG+G G  C T      G    Q +AV + A  A    
Sbjct: 155 AGNVTTPEGIRDMESWGANAIKVGLGPGHACTTSPRTGFGSRGWQLSAVARCAKVAT--K 212

Query: 353 VPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLE 412
             +I DGG  + G I K++ +GA  +M G L +GT E+PGE    DGVR K Y G  SL 
Sbjct: 213 AVIICDGGASNSGDIAKAINMGADWIMSGFLFSGTLESPGEIVVRDGVRCKSYYGSSSLV 272

Query: 413 A 413
           A
Sbjct: 273 A 273


>UniRef50_Q2JL45 Cluster: IMP dehydrogenase family protein; n=43;
           Bacteria|Rep: IMP dehydrogenase family protein -
           Synechococcus sp. (strain JA-2-3B'a(2-13))
           (Cyanobacteria bacteriumYellowstone B-Prime)
          Length = 387

 Score = 84.2 bits (199), Expect = 7e-15
 Identities = 50/111 (45%), Positives = 64/111 (57%), Gaps = 6/111 (5%)

Query: 291 IQVVGGNVVTRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARH 350
           I VV GN VT   A  L+ AG   + VG+G G+ C ++ V+  G PQATA+   A+    
Sbjct: 188 IPVVVGNCVTYDVALELMQAGAAGVLVGIGPGAACTSRGVLGVGVPQATAIADCAAAREQ 247

Query: 351 F------NVPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEAPGEYF 395
           F       VPVIADGG+ + G I K++A GA  VM+GS LA   EAPG  F
Sbjct: 248 FLAETGAYVPVIADGGLVTGGDICKAIACGADAVMIGSPLARAYEAPGRGF 298


>UniRef50_Q5RGU9 Cluster: Novel protein similar to vertebrate IMP
           (Inosine monophosphate) dehydrogenase 1; n=1; Danio
           rerio|Rep: Novel protein similar to vertebrate IMP
           (Inosine monophosphate) dehydrogenase 1 - Danio rerio
           (Zebrafish) (Brachydanio rerio)
          Length = 126

 Score = 77.4 bits (182), Expect = 8e-13
 Identities = 35/47 (74%), Positives = 41/47 (87%)

Query: 11  DGLSAEDTFANSEGLTYNDFLLLPGYIDFTAEEVDLTSPLTKKILLK 57
           DGLSA+  FA  +GLTYNDFL+LPG+IDFT++EVDLTS LTKKI LK
Sbjct: 80  DGLSAQQLFAVGDGLTYNDFLILPGFIDFTSDEVDLTSALTKKITLK 126


>UniRef50_Q7VQ71 Cluster: GuaB gene for inosine 5-monophosphase
           dehydrogenase subunit; n=4; cellular organisms|Rep: GuaB
           gene for inosine 5-monophosphase dehydrogenase subunit -
           Chlamydia pneumoniae (Chlamydophila pneumoniae)
          Length = 87

 Score = 73.7 bits (173), Expect = 1e-11
 Identities = 33/82 (40%), Positives = 54/82 (65%)

Query: 23  EGLTYNDFLLLPGYIDFTAEEVDLTSPLTKKILLKAPLVSTPMDTVTEADMAISMALCGG 82
           E LT++D LL+P Y +    EV L + ++K + L  P++S  MD+VTE  MA+++A  GG
Sbjct: 3   EALTFDDVLLIPQYSEILPSEVSLKTAISKTLSLNIPILSAAMDSVTETAMALALAQEGG 62

Query: 83  IGIIHHNCTPEYQANEVHKVKK 104
           +GI+H N +   Q++ V K+K+
Sbjct: 63  LGILHKNMSEVEQSSSVRKIKE 84


>UniRef50_Q4T162 Cluster: Chromosome 21 SCAF10714, whole genome
           shotgun sequence; n=2; cellular organisms|Rep:
           Chromosome 21 SCAF10714, whole genome shotgun sequence -
           Tetraodon nigroviridis (Green puffer)
          Length = 364

 Score = 70.9 bits (166), Expect = 7e-11
 Identities = 38/120 (31%), Positives = 66/120 (55%), Gaps = 2/120 (1%)

Query: 240 VGAAIGTRDTDRERLKLLVNN--GVDVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGN 297
           V A+ G+   D E+L  ++     +  I LD + G S + ++ +K ++E +P+  ++ GN
Sbjct: 104 VAASSGSSAADLEKLCSVLEAVPALQYICLDVANGYSEHFVEFVKMVREKFPKHTIMAGN 163

Query: 298 VVTRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFNVPVIA 357
           VVT    + LI +G D ++VG+G GS+C T+     G PQ +AV + A  A      +I+
Sbjct: 164 VVTGEMVEELILSGADIIKVGIGPGSVCTTRIKTGVGYPQLSAVIECADSAHGLKGHIIS 223


>UniRef50_Q8EUA0 Cluster: Guanosine 5'-monophosphate oxidoreductase;
           n=1; Mycoplasma penetrans|Rep: Guanosine
           5'-monophosphate oxidoreductase - Mycoplasma penetrans
          Length = 378

 Score = 70.9 bits (166), Expect = 7e-11
 Identities = 43/146 (29%), Positives = 73/146 (50%), Gaps = 12/146 (8%)

Query: 265 IVLDSSQGNSTYQIKMIKYIKETYP-EIQVVGGNVVTRMQAKNLIDAGVDALRVGMGSGS 323
           I++D S G+       I+ +K  +  +I ++ GN+   +  + L +AG D +RVG+G+G 
Sbjct: 112 ILIDISNGHMRRLANSIRDLKRIFRNKISIMCGNIANPLTFQYLSEAGADYIRVGIGAGC 171

Query: 324 ICITQEVMACGCPQATAVYQVASYARHFN-----------VPVIADGGIQSVGHIIKSLA 372
            CIT        P  + +Y+                      ++ADGG+++  +IIKSL 
Sbjct: 172 GCITASNTGIFYPMGSLIYECRKIQEKMEESYRLNGTSKPAKIVADGGMKNYDYIIKSLY 231

Query: 373 LGASTVMMGSLLAGTSEAPGEYFFSD 398
           LGA  VM G L +   E+PGE ++ +
Sbjct: 232 LGADYVMCGRLFSQCWESPGEIWYKE 257


>UniRef50_A1SMV5 Cluster: IMP dehydrogenase family protein; n=7;
           Actinobacteridae|Rep: IMP dehydrogenase family protein -
           Nocardioides sp. (strain BAA-499 / JS614)
          Length = 368

 Score = 69.7 bits (163), Expect = 2e-10
 Identities = 49/152 (32%), Positives = 77/152 (50%), Gaps = 11/152 (7%)

Query: 255 KLLVNNGVDVIVLDSSQGNSTY---QIKMIKYIKETYP-EIQVVGGNVVTRMQAKNLIDA 310
           K +V+ GVD+ V+  +  ++ +   Q + +   +  Y  ++ VV G   T   A +L+  
Sbjct: 148 KAVVDAGVDMFVIRGTTVSAEHVSSQAEPLNLKEFIYELDVPVVVGGCATHQAALHLMRT 207

Query: 311 GVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHF-------NVPVIADGGIQS 363
           G   + VG G G+   T+ V+    P A+AV  VA+  R +        V VIADG I  
Sbjct: 208 GAAGVLVGFGGGAAHTTRTVLGVAVPMASAVADVAAARRDYLDESGGRYVHVIADGSIGK 267

Query: 364 VGHIIKSLALGASTVMMGSLLAGTSEAPGEYF 395
            G + K++A GA  VM+GS  A  ++APG  F
Sbjct: 268 SGDVAKAIACGADAVMVGSPFARATDAPGRGF 299


>UniRef50_Q03YG3 Cluster: IMP dehydrogenase/GMP reductase; n=1;
           Leuconostoc mesenteroides subsp. mesenteroides ATCC
           8293|Rep: IMP dehydrogenase/GMP reductase - Leuconostoc
           mesenteroides subsp. mesenteroides (strain ATCC 8293
           /NCDO 523)
          Length = 328

 Score = 68.9 bits (161), Expect = 3e-10
 Identities = 52/170 (30%), Positives = 78/170 (45%), Gaps = 6/170 (3%)

Query: 227 YPNASKDSNKQLLVGAAIGTRDTDRERLKLLVNNGVDVIVLDSSQGNSTYQIKMIKYIKE 286
           YPNA  DS   L V A +        R+  LVN G D I     +  +     +IK I++
Sbjct: 96  YPNALVDSQNHLRVAAEVWLVAGAETRVAALVNAGADAIFFYLHETLAKNTRDLIKQIRQ 155

Query: 287 TYPEIQVVGGNVVTRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVAS 346
            +P++ +  G V  +  A  L +AG D +  G    S  +  ++     P  T    +A 
Sbjct: 156 AHPDLFIAVGVVEDQSIAAALYEAGADTILAGRSVDS-SLPNDITY---PFLTVTMNIAD 211

Query: 347 YARHF-NVPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGT-SEAPGEY 394
            A  + N  VIA GGI   G I+K++A GA   M+  LL G+  E+ G +
Sbjct: 212 VAAAYDNKSVIAVGGIHYSGDIVKAIAAGADATMVSDLLKGSVLESDGSF 261



 Score = 38.3 bits (85), Expect = 0.48
 Identities = 25/81 (30%), Positives = 39/81 (48%), Gaps = 1/81 (1%)

Query: 24  GLTYNDFLLLPGYIDFTAEEVDLTSPLTKKILLKAPLVSTPMDTVTEADMAISMALCGGI 83
           GL Y+  LL+PG  +     V L + L++   L  PLVS      T+  +A   AL GG+
Sbjct: 9   GLGYDQVLLVPGASNVLPYSVTLRTQLSENFELNIPLVSEAFGPETDTRVA-PTALNGGL 67

Query: 84  GIIHHNCTPEYQANEVHKVKK 104
           G++        Q   + +VK+
Sbjct: 68  GVVAEQEDLSKQVASLQQVKE 88


>UniRef50_P74477 Cluster: Chloride channel protein; n=3;
           Chroococcales|Rep: Chloride channel protein -
           Synechocystis sp. (strain PCC 6803)
          Length = 899

 Score = 65.7 bits (153), Expect = 3e-09
 Identities = 34/102 (33%), Positives = 58/102 (56%), Gaps = 7/102 (6%)

Query: 121 TVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDI-DFREGDPHLSLKEVMTPINDM 179
           T+A VL     +   G+P+ Q    GG+L+G+ T  D+ +  +   H++LK++MTP  + 
Sbjct: 471 TLAQVLPIMSNSHHRGFPVVQ----GGKLVGVFTQTDLANAAQESVHIALKQIMTP--NP 524

Query: 180 ITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
           IT      L D  Y+L + +  +LP++  D +LV +I RTD+
Sbjct: 525 ITVDPEAPLSDVLYLLNRYQLSRLPVVEGDNKLVGIITRTDI 566


>UniRef50_A6Y440 Cluster: GMP reductase; n=1; Vibrio cholerae
           RC385|Rep: GMP reductase - Vibrio cholerae RC385
          Length = 248

 Score = 64.5 bits (150), Expect = 6e-09
 Identities = 34/122 (27%), Positives = 68/122 (55%), Gaps = 4/122 (3%)

Query: 232 KDSNKQLL--VGAAIGTRDTDRERLK--LLVNNGVDVIVLDSSQGNSTYQIKMIKYIKET 287
           K ++K  L  V  + GT + D ++ K  + +++ +  I +D + G S + ++ ++ ++  
Sbjct: 89  KSADKATLNNVMVSTGTSEADFQKTKDVMALSDELIFICIDIANGYSEHLVEYVQRVRAA 148

Query: 288 YPEIQVVGGNVVTRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASY 347
           +P+  +  GNVVT    + LI AG D ++VG+G GS+C T+     G PQ +A+ +  + 
Sbjct: 149 FPDKVISAGNVVTGDMVEELILAGADIVKVGIGPGSVCTTRVKTGVGYPQLSAIIEYTAQ 208

Query: 348 AR 349
            +
Sbjct: 209 TK 210


>UniRef50_P65170 Cluster: Uncharacterized oxidoreductase
           Rv3410c/MT3518; n=31; Actinomycetales|Rep:
           Uncharacterized oxidoreductase Rv3410c/MT3518 -
           Mycobacterium tuberculosis
          Length = 375

 Score = 64.5 bits (150), Expect = 6e-09
 Identities = 48/155 (30%), Positives = 79/155 (50%), Gaps = 16/155 (10%)

Query: 256 LLVNNGVDVIVLDSS------QGNSTYQIKMIKYIKETYPEIQVVGGNVVTRMQAKNLID 309
           +LV  G+D++V+  +        +    + +  +I E   +I VV G V+    A +L+ 
Sbjct: 152 VLVAAGIDLLVIQGTIVSAERVASDGEPLNLKTFISEL--DIPVVAGGVLDHRTALHLMR 209

Query: 310 AGVDALRVGMGSGS-ICITQEVMACGCPQATAVYQVASYARHF-------NVPVIADGGI 361
            G   + VG GS   +  T EV+    P ATA+   A+  R +        V V+ADG I
Sbjct: 210 TGAAGVIVGYGSTQGVTTTDEVLGISVPMATAIADAAAARRDYLDETGGRYVHVLADGDI 269

Query: 362 QSVGHIIKSLALGASTVMMGSLLAGTSEAPGEYFF 396
            + G + K++A GA  V++G+ LA ++EA GE +F
Sbjct: 270 HTSGELAKAIACGADAVVLGTPLAESAEALGEGWF 304


>UniRef50_Q57647 Cluster: Uncharacterized protein MJ0188; n=6;
           Methanococcales|Rep: Uncharacterized protein MJ0188 -
           Methanococcus jannaschii
          Length = 265

 Score = 63.3 bits (147), Expect = 1e-08
 Identities = 34/112 (30%), Positives = 62/112 (55%), Gaps = 6/112 (5%)

Query: 114 VCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLKEVM 173
           V +  +NTV DV++  K+ G   +P+ +NGK    LIGIV+  DI  +  D +  ++ VM
Sbjct: 14  VTVSKDNTVKDVIKLLKETGHNSFPVVENGK----LIGIVSVHDIVGK--DDNEKVENVM 67

Query: 174 TPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKAR 225
           T   DM+       + D   I+ ++   KLP+++ +  LV +I+  D+ +++
Sbjct: 68  TKRKDMVVTTPDANIMDVGRIMFRTGFSKLPVVDEENNLVGIISNMDVIRSQ 119


>UniRef50_Q0S3A9 Cluster: Possible IMP dehydrogenase/GMP reductase;
           n=17; Actinobacteria (class)|Rep: Possible IMP
           dehydrogenase/GMP reductase - Rhodococcus sp. (strain
           RHA1)
          Length = 379

 Score = 62.9 bits (146), Expect = 2e-08
 Identities = 49/147 (33%), Positives = 72/147 (48%), Gaps = 11/147 (7%)

Query: 254 LKLLVNNGVDVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVVTRMQAKNLIDAGVD 313
           + LLV +G  +       G+S   + +  +I E   ++ VV G V     A +L+  G  
Sbjct: 161 IDLLVVHGTIISAEHVVHGDSE-PLNLKTFISEL--DVPVVAGGVSDHRTALHLMRTGAA 217

Query: 314 ALRVGMGSGS-ICITQEVMACGCPQATAVYQVASYARHF-------NVPVIADGGIQSVG 365
            + VG GS      T EV+  G P ATA+   A+  R +        V VIADG I S G
Sbjct: 218 GVIVGYGSTEGATTTGEVLGIGLPMATAIADAAAARRDYLDETGGRYVHVIADGDITSSG 277

Query: 366 HIIKSLALGASTVMMGSLLAGTSEAPG 392
            + K++A GA   ++G+ LA  +EAPG
Sbjct: 278 DLAKAIACGADAAVLGAPLAVAAEAPG 304


>UniRef50_O27343 Cluster: Inosine-5'-monophosphate dehydrogenase
           related protein VI; n=3; Methanobacteriaceae|Rep:
           Inosine-5'-monophosphate dehydrogenase related protein
           VI - Methanobacterium thermoautotrophicum
          Length = 269

 Score = 62.1 bits (144), Expect = 3e-08
 Identities = 50/176 (28%), Positives = 91/176 (51%), Gaps = 20/176 (11%)

Query: 111 RDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLK 170
           RD + +  + + A++++  K+ G  G+P+  NG +    IG+VT+ D+  +     +S  
Sbjct: 13  RDVITVSSDTSTAEIIKLMKETGHDGFPVKDNGSV----IGMVTAFDLLIKPWVKTVS-- 66

Query: 171 EVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKA---RSY 227
           E+M+   D++ A   ++L DA  ++ +    +LP+IN +G+LV +I  TD+ ++   RS 
Sbjct: 67  EIMS--RDVVVADQDMSLNDAARVMFRMGISRLPVINKEGKLVGIITNTDIVRSHIERST 124

Query: 228 P---NASKDSNKQLL-VGAAIGTRDTDRERLKLLVNNGVDVIVLDSSQGNSTYQIK 279
           P   N  K + +QL  V   +       E+L+   N     +  D  QG  TY+IK
Sbjct: 125 PMKVNYFKKTLEQLYGVKPEVKRMKVPIEKLRPTQNK----VYADELQGR-TYEIK 175


>UniRef50_O29009 Cluster: Inosine monophosphate dehydrogenase,
           putative; n=4; Euryarchaeota|Rep: Inosine monophosphate
           dehydrogenase, putative - Archaeoglobus fulgidus
          Length = 259

 Score = 57.2 bits (132), Expect = 1e-06
 Identities = 28/122 (22%), Positives = 67/122 (54%), Gaps = 7/122 (5%)

Query: 104 KYKHGFIRDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREG 163
           K K    ++   + P+NTV D +E  +K G   +P+  +     R++G +++  +D  + 
Sbjct: 4   KVKDYMTKNVYTLKPDNTVKDAIELVRKTGHDSFPVVDDNM---RVVGYISA--VDLLDK 58

Query: 164 DPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKK 223
            P   ++++M+   ++  A+  + L+DA  ++ ++   KLP+++ D  LV +I+  D+ +
Sbjct: 59  SPETKIRDIMS--RELYVARDFMDLRDAARVMFRTGHSKLPVVDEDNRLVGIISNADVIR 116

Query: 224 AR 225
           ++
Sbjct: 117 SQ 118


>UniRef50_O28857 Cluster: Chloride channel, putative; n=2;
           Euryarchaeota|Rep: Chloride channel, putative -
           Archaeoglobus fulgidus
          Length = 589

 Score = 56.0 bits (129), Expect = 2e-06
 Identities = 37/118 (31%), Positives = 67/118 (56%), Gaps = 12/118 (10%)

Query: 114 VCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDID---FREGDPHLSLK 170
           V + P   V++VLE  +K G  G+P+     + GRL+G+VT  D++     E D  L ++
Sbjct: 471 VVVTPYQRVSEVLELIEKTGHMGFPVV----MDGRLVGMVTFEDVERVPLEERDKKL-VR 525

Query: 171 EVMTPINDMITAQLGVTLQDANYILEKSKKGKLPII--NNDGELVALIARTDLKKARS 226
           ++MT   ++I      TL++A   L     G+LP++  N++ +L+ +I R+D+ KA +
Sbjct: 526 DIMT--RELIVTYPDETLEEALIKLVDKGIGRLPVVDRNDEKKLLGIITRSDIMKAHA 581


>UniRef50_Q191T3 Cluster: Polynucleotide adenylyltransferase region
           precursor; n=3; Bacteria|Rep: Polynucleotide
           adenylyltransferase region precursor -
           Desulfitobacterium hafniense (strain DCB-2)
          Length = 873

 Score = 55.6 bits (128), Expect = 3e-06
 Identities = 31/128 (24%), Positives = 67/128 (52%), Gaps = 9/128 (7%)

Query: 96  ANEVHKVKKYKHGFIRDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTS 155
           A + H++ + +         + PE  +++V +   K G TG P+ Q    G +L+GI++ 
Sbjct: 298 AQQAHRINRVRDIMSYPVKTVSPEMKLSEVEQILLKYGHTGVPVAQ----GEKLVGIISR 353

Query: 156 RDID--FREGDPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELV 213
           RD+D   + G  H  +K  MT   D++  +   + +D    + +   G++P++  +G+L 
Sbjct: 354 RDVDKAIKHGLAHAPVKGFMT--KDVVVVEADSSWEDVQRTMVQHDIGRVPVL-EEGKLA 410

Query: 214 ALIARTDL 221
            +++R+D+
Sbjct: 411 GIVSRSDI 418


>UniRef50_O26907 Cluster: Sporulation protein IVFB related protein;
           n=1; Methanothermobacter thermautotrophicus str. Delta
           H|Rep: Sporulation protein IVFB related protein -
           Methanobacterium thermoautotrophicum
          Length = 341

 Score = 55.6 bits (128), Expect = 3e-06
 Identities = 37/118 (31%), Positives = 63/118 (53%), Gaps = 9/118 (7%)

Query: 112 DPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLKE 171
           +PV + P  TV + L+   +    GYP+T+     G L GIVT  DI     D  L +++
Sbjct: 229 NPVTLHPHMTVKEALDVMFREKHMGYPVTE----AGELRGIVTFHDISDASRD--LRVED 282

Query: 172 VMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKARSYPN 229
           VMT   D++T +    +  A   + + + G+LP++  DG+L  +I+RTD+ +  +  N
Sbjct: 283 VMT--GDVVTVRDDEEVTGALEKMNRLQLGRLPVM-RDGKLTGIISRTDIVRTLNLMN 337


>UniRef50_Q2NEF3 Cluster: Putative uncharacterized protein; n=1;
           Methanosphaera stadtmanae DSM 3091|Rep: Putative
           uncharacterized protein - Methanosphaera stadtmanae
           (strain DSM 3091)
          Length = 311

 Score = 54.4 bits (125), Expect = 7e-06
 Identities = 55/225 (24%), Positives = 103/225 (45%), Gaps = 24/225 (10%)

Query: 111 RDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDI-DFREG------ 163
           +D V     +++ ++     KN F   PIT  G   G+L+GIVT+ DI DF  G      
Sbjct: 34  KDVVTAPQSSSIIEIANLMSKNDFRRIPITDPGS--GKLLGIVTTMDILDFFGGGKKYNI 91

Query: 164 --DPHLS--LKEVMTPINDMITAQLGV-----TLQDANYILEKSKKGKLPIINNDGELVA 214
             D H    L  +  PI +++T  +       T+ D   ++ +   G LPIINND ++V 
Sbjct: 92  ITDKHKGNFLSAINAPIKEIMTVGVKTMTNTDTIVDTTTLMLEEGIGGLPIINNDEKIVG 151

Query: 215 LIARTDLKKARSYPNASKDSNKQLLVGAAIGTRDTDRERL-KLLVNNGV-DVIVLDSSQG 272
           ++   D+ K      A  +    +       T  T  E + K++V N +  V ++   Q 
Sbjct: 152 IVTEGDIVKKLGKLCADLEVQDIMATNVITTTPGTPIEGIAKIMVRNSLRRVPIVGEDQE 211

Query: 273 NSTYQIKMIKYIKETYPEIQVVGGNVVTRMQAKNLIDAGVDALRV 317
           + + + K++ ++  +   ++ +G +   ++ AK   + G D ++V
Sbjct: 212 SQSKEEKLLGFVTAS-DILKYIGDH---KLFAKLFSNEGEDVVKV 252


>UniRef50_Q97F91 Cluster: Proline/glycine betaine ABC-type transport
           system, ATPase component; n=42; Bacteria|Rep:
           Proline/glycine betaine ABC-type transport system,
           ATPase component - Clostridium acetobutylicum
          Length = 377

 Score = 53.6 bits (123), Expect = 1e-05
 Identities = 39/132 (29%), Positives = 62/132 (46%), Gaps = 6/132 (4%)

Query: 104 KYKHGFIRDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREG 163
           K K   I + +   PE T    LE  K N      +        +L+GIVT R++ F   
Sbjct: 249 KVKDIMINNVIKSSPERTSIQALEIMKSNHVDRLIVASKDN---KLLGIVTLRELKFSIN 305

Query: 164 DPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKK 223
           + +  LK++M   N++ T     ++ +   I+E  K G +P+INND  LV LI ++ L  
Sbjct: 306 E-NKKLKDIMK--NNITTINENDSIVNVLDIVENQKIGFIPVINNDSSLVGLITKSSLLS 362

Query: 224 ARSYPNASKDSN 235
             S    +K+ N
Sbjct: 363 VLSNQFINKEVN 374


>UniRef50_Q02B15 Cluster: Putative signal-transduction protein with
           CBS domains; n=1; Solibacter usitatus Ellin6076|Rep:
           Putative signal-transduction protein with CBS domains -
           Solibacter usitatus (strain Ellin6076)
          Length = 147

 Score = 53.6 bits (123), Expect = 1e-05
 Identities = 38/130 (29%), Positives = 67/130 (51%), Gaps = 8/130 (6%)

Query: 104 KYKHGFIRDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFR-- 161
           K K     DPVC  P +TV++V +  K       P+ ++ +   +L+GI+T RD+  +  
Sbjct: 2   KCKQAMTPDPVCCIPTDTVSNVAKRMKTEDVGSLPVCES-RTSRKLVGIITDRDLAIKVV 60

Query: 162 --EGDPH-LSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIAR 218
               DP+ ++  +VMT  N M T      L  A + ++  +  ++PI+N+ G LV +I++
Sbjct: 61  ADSRDPNKVTTGDVMT-WNPM-TCHPDDDLDIAVHSMQSEQVRRIPIVNDAGVLVGIISQ 118

Query: 219 TDLKKARSYP 228
            D+    S P
Sbjct: 119 ADIALRGSRP 128


>UniRef50_Q64C69 Cluster: Chloride channel; n=1; uncultured archaeon
           GZfos26B2|Rep: Chloride channel - uncultured archaeon
           GZfos26B2
          Length = 608

 Score = 53.6 bits (123), Expect = 1e-05
 Identities = 33/114 (28%), Positives = 61/114 (53%), Gaps = 8/114 (7%)

Query: 112 DPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDID-FREGD-PHLSL 169
           D + + P N V  VL    K G  GYP+  +     RL+G+VT +D +  + GD   + +
Sbjct: 491 DVMPVNPTNNVQTVLNLITKYGHIGYPVLDDN----RLVGVVTFKDAERVQAGDREEVLV 546

Query: 170 KEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINND--GELVALIARTDL 221
            +VMTP   +I      +L+DA   L  +  G+LP+++ D   +++ ++ ++D+
Sbjct: 547 DQVMTPATSLIVTYPDESLEDALRKLVLNDIGRLPVVDRDDQSKILGIVTKSDI 600


>UniRef50_O27290 Cluster: Inosine-5'-monophosphate dehydrogenase
           related protein I; n=1; Methanothermobacter
           thermautotrophicus str. Delta H|Rep:
           Inosine-5'-monophosphate dehydrogenase related protein I
           - Methanobacterium thermoautotrophicum
          Length = 275

 Score = 53.2 bits (122), Expect = 2e-05
 Identities = 35/119 (29%), Positives = 61/119 (51%), Gaps = 12/119 (10%)

Query: 112 DPVCMGPENTVADVLE-AKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGD------ 164
           DPVC+  +  + D L    K+N      I  N      L+GIVT +DI  + G       
Sbjct: 13  DPVCIDKDQNICDALRLMDKRNVSRLLVINTNSDHERELVGIVTEKDIALKLGSSRYGNM 72

Query: 165 --PHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
              H  +  VMTP  ++ITA+  +   +A  ++ ++  G LP++ +DGE++ ++ ++DL
Sbjct: 73  APSHFHVSTVMTP--ELITAEPDMDAGNAASVMLENNIGSLPVL-HDGEIMGIVTKSDL 128


>UniRef50_Q4TGB6 Cluster: Chromosome undetermined SCAF3807, whole
           genome shotgun sequence; n=1; Tetraodon
           nigroviridis|Rep: Chromosome undetermined SCAF3807,
           whole genome shotgun sequence - Tetraodon nigroviridis
           (Green puffer)
          Length = 258

 Score = 52.8 bits (121), Expect = 2e-05
 Identities = 45/189 (23%), Positives = 84/189 (44%), Gaps = 8/189 (4%)

Query: 241 GAAIGTRDTDRERLKLLVNNGVDV--IVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNV 298
           G + GT +TD ER+  ++    ++  I +D + G S + +  +K ++E +P   ++ G +
Sbjct: 2   GFSTGTGETDFERISAILAAVPELQYICVDVANGYSEHFVHFVKDVREKFPSHTIMVGPL 61

Query: 299 VTRMQAKNLIDAGVDALRVG-MGSGSICITQEVMACGCPQATAVYQVASYARHFNVPVIA 357
             R +   L+   +   + G + +G +   +E++  G           S           
Sbjct: 62  PPRPRQPALLHRRISVCQAGNVVTGEM--VEELILAGADIIKVGIGPGSVCT--TRKKTG 117

Query: 358 DGGIQSVGHIIKSLALGASTVMMGSLLAGTSEAPGEYFFSDGVRLKKY-RGMGSLEAMES 416
           DGG    G + K+   GA  VM+G +LAG SE+ G+     G + K + R        E+
Sbjct: 118 DGGCTCPGDVSKAFGAGADFVMLGGMLAGHSESGGDIIEKSGKKYKLFLRNELRHGHEEA 177

Query: 417 KDGKGSAMS 425
           + G+G   S
Sbjct: 178 RGGRGRVQS 186


>UniRef50_Q9HRK9 Cluster: Inosine-5'-monophosphate dehydrogenase;
           n=5; Euryarchaeota|Rep: Inosine-5'-monophosphate
           dehydrogenase - Halobacterium salinarium (Halobacterium
           halobium)
          Length = 272

 Score = 52.0 bits (119), Expect = 4e-05
 Identities = 33/115 (28%), Positives = 62/115 (53%), Gaps = 8/115 (6%)

Query: 111 RDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLK 170
           RD   +  ++TV+DV     ++   G+P+T     G  + G V++RD+     DP   L 
Sbjct: 21  RDVATVSADDTVSDVAARISESDHNGFPVTD----GRHVEGFVSARDLLL--ADPDELLF 74

Query: 171 EVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKAR 225
           +VMT   D++ A   + + DA  ++ +S   KLP++++ G LV +I   D+ +++
Sbjct: 75  KVMT--EDLVVAHPEMDVTDAARVILRSGIQKLPVVDDAGNLVGIITNADVIRSQ 127


>UniRef50_Q2ACT2 Cluster: CBS:Phosphoesterase,
           RecJ-like:Polynucleotide adenylyltransferase
           region:Phosphoesterase, DHHA1; n=1; Halothermothrix
           orenii H 168|Rep: CBS:Phosphoesterase,
           RecJ-like:Polynucleotide adenylyltransferase
           region:Phosphoesterase, DHHA1 - Halothermothrix orenii H
           168
          Length = 865

 Score = 51.6 bits (118), Expect = 5e-05
 Identities = 32/108 (29%), Positives = 62/108 (57%), Gaps = 9/108 (8%)

Query: 116 MGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDID-FREGDP-HLSLKEVM 173
           + P+  + +V +   K G TG  + +NG++    +G+ + RD++  +E D  H  +K  M
Sbjct: 319 VNPDTRIGEVEKILDKYGHTGIVVCENGEI----VGVFSKRDLNKVKEHDLLHSPVKGYM 374

Query: 174 TPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
           +   D+IT  +  T++ A  ++ K   G+LP+I  DG+LV ++ R+D+
Sbjct: 375 S--TDVITIDVDETIRYAQKLMVKYDIGRLPVI-EDGKLVGIVTRSDI 419


>UniRef50_Q3AAR6 Cluster: PolyA polymerase family protein; n=1;
           Carboxydothermus hydrogenoformans Z-2901|Rep: PolyA
           polymerase family protein - Carboxydothermus
           hydrogenoformans (strain Z-2901 / DSM 6008)
          Length = 864

 Score = 51.2 bits (117), Expect = 6e-05
 Identities = 32/112 (28%), Positives = 61/112 (54%), Gaps = 9/112 (8%)

Query: 119 ENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDID--FREGDPHLSLKEVMTPI 176
           ++TV +  +   + G +G P+ +    G +L+GI++ RD+D        H  +K  M+  
Sbjct: 323 DSTVEEARKIMVRYGHSGLPVLE----GDKLVGIISRRDVDKIIHHNLGHAPVKAYMS-- 376

Query: 177 NDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKARSYP 228
            + +T +   +L++A  +L K   G+LP++   G+L+ +I+RTDL K    P
Sbjct: 377 KNPVTIEPEASLEEALRLLIKHDIGRLPVVEG-GKLIGIISRTDLLKQYHRP 427


>UniRef50_A7HLG0 Cluster: Polynucleotide adenylyltransferase region;
           n=2; Thermotogaceae|Rep: Polynucleotide
           adenylyltransferase region - Fervidobacterium nodosum
           Rt17-B1
          Length = 883

 Score = 50.8 bits (116), Expect = 8e-05
 Identities = 36/156 (23%), Positives = 77/156 (49%), Gaps = 8/156 (5%)

Query: 121 TVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDID--FREGDPHLSLKEVMTPIND 178
           ++ +V +  +  G +G P+ +    G +L+GIVT + +D     G     +K +M+  + 
Sbjct: 334 SIEEVNKIMEITGHSGMPVVE----GNKLVGIVTKKTVDKALNHGLGKRPIKSIMS--SK 387

Query: 179 MITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKARSYPNASKDSNKQL 238
           +ITA+L   +     ++ ++  G++PI++ +  LV ++ R+D+ +A S P  S    ++ 
Sbjct: 388 LITAKLDTPVSVLRKLMIENDIGRIPILDENNILVGIVTRSDIIRAESSPKKSYLEKREE 447

Query: 239 LVGAAIGTRDTDRERLKLLVNNGVDVIVLDSSQGNS 274
           +            ERL   + N + +I    ++ NS
Sbjct: 448 IKTTFNNISHLINERLSRRIVNLLRLIGFFGNEMNS 483


>UniRef50_A1HSL2 Cluster: Putative signal transduction protein with
           CBS domains; n=1; Thermosinus carboxydivorans Nor1|Rep:
           Putative signal transduction protein with CBS domains -
           Thermosinus carboxydivorans Nor1
          Length = 214

 Score = 50.8 bits (116), Expect = 8e-05
 Identities = 40/128 (31%), Positives = 63/128 (49%), Gaps = 24/128 (18%)

Query: 112 DPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDP------ 165
           +PV + P  TVAD  E  + + F   P+       GRL+GIVT RD+  RE  P      
Sbjct: 10  NPVTISPTATVADASELMRTHKFRRLPVVDK----GRLVGIVTDRDL--REVSPSPATTL 63

Query: 166 ----------HLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVAL 215
                      + +KEVM    ++IT +   T+++A  ++  +K G L ++N  G +V +
Sbjct: 64  SIFELNYLLAKMQVKEVMR--TNVITIRDDATIEEAALLMYNNKIGGLVVVNAAGAVVGI 121

Query: 216 IARTDLKK 223
           I  TD+ K
Sbjct: 122 ITETDIFK 129


>UniRef50_A6TR64 Cluster: Polynucleotide adenylyltransferase region
           precursor; n=1; Alkaliphilus metalliredigens QYMF|Rep:
           Polynucleotide adenylyltransferase region precursor -
           Alkaliphilus metalliredigens QYMF
          Length = 875

 Score = 50.4 bits (115), Expect = 1e-04
 Identities = 30/104 (28%), Positives = 57/104 (54%), Gaps = 9/104 (8%)

Query: 122 VADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDID--FREGDPHLSLKEVMTPINDM 179
           + +V +   + G TG P+ +    G ++IGI++  D+D     G  H  +K  MT   ++
Sbjct: 326 IQEVNKIMLRYGHTGMPVLE----GDQMIGIISRTDVDKAIIHGLGHAPVKGFMT--KNV 379

Query: 180 ITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKK 223
            T     TL++ N +L ++  G+LP++  D +L+ ++ RTD+ K
Sbjct: 380 KTINPSTTLKEMNLLLTRNNIGRLPVV-EDNQLIGIVTRTDVLK 422


>UniRef50_A4J3L2 Cluster: Polynucleotide adenylyltransferase region
           precursor; n=2; Peptococcaceae|Rep: Polynucleotide
           adenylyltransferase region precursor - Desulfotomaculum
           reducens MI-1
          Length = 907

 Score = 50.4 bits (115), Expect = 1e-04
 Identities = 34/132 (25%), Positives = 68/132 (51%), Gaps = 11/132 (8%)

Query: 93  EYQANEVHKVKKYKHGFIRDPVCMG-PENTVADVLEAKKKNGFTGYPITQNGKLGGRLIG 151
           E    ++H +   K   +  PV M  PE T+ +  +   + G TG P+ ++GKL     G
Sbjct: 299 ELVKEKIHPLLTVKD-IMSSPVKMVFPETTIEEAGKIMLRYGHTGLPVIKDGKLS----G 353

Query: 152 IVTSRDID--FREGDPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINND 209
           +++ RD++     G  H  +K  MT   ++IT Q  + + D   ++ +   G+LP++  +
Sbjct: 354 VISRRDVEKATHHGLGHAPVKGYMT--TNVITVQKDMNIHDVQDLMIEKDIGRLPVVEGN 411

Query: 210 GELVALIARTDL 221
             ++ +++RTD+
Sbjct: 412 -MVIGIVSRTDV 422


>UniRef50_Q31MV1 Cluster: CBS; n=3; Synechococcus elongatus|Rep: CBS
           - Synechococcus sp. (strain PCC 7942) (Anacystis
           nidulans R2)
          Length = 859

 Score = 50.0 bits (114), Expect = 1e-04
 Identities = 33/108 (30%), Positives = 57/108 (52%), Gaps = 10/108 (9%)

Query: 122 VADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDID---FREGDPHLSLKEVMTPIND 178
           + +V++   +    G+P+TQ G L    +GIVTS D+D    +     + L E+MTP   
Sbjct: 455 LTEVIQQFNRTHHRGFPVTQKGAL----VGIVTSSDLDEQTLKGKGESVRLSEIMTP--H 508

Query: 179 MITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKARS 226
            +T     TL    Y+L + +  +LP+++   +LV +I R D+ +A S
Sbjct: 509 PLTVAPQDTLAHVLYVLNRFQISRLPVVDG-RKLVGIITRADIIRAES 555


>UniRef50_Q58629 Cluster: Uncharacterized protein MJ1232; n=6;
           Methanococcales|Rep: Uncharacterized protein MJ1232 -
           Methanococcus jannaschii
          Length = 296

 Score = 50.0 bits (114), Expect = 1e-04
 Identities = 31/114 (27%), Positives = 59/114 (51%), Gaps = 6/114 (5%)

Query: 110 IRDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSL 169
           I++   + P  T+ +  +   +   +G P+  N KL    +G+++  DI     +    +
Sbjct: 177 IKEVWTINPNCTLRETAKLFAEKYISGAPVVDNDKL----VGVISLHDIAENIDNIDKKV 232

Query: 170 KEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKK 223
           KEVM    D+IT      + DA  I+ K+  G+L I++++ ++V +I RTD+ K
Sbjct: 233 KEVMR--RDVITIHKDEKIYDALKIMNKNNVGRLVIVDDNNKIVGIITRTDILK 284


>UniRef50_A7HD42 Cluster: Putative signal transduction protein with
           CBS domains precursor; n=2; Anaeromyxobacter|Rep:
           Putative signal transduction protein with CBS domains
           precursor - Anaeromyxobacter sp. Fw109-5
          Length = 166

 Score = 49.6 bits (113), Expect = 2e-04
 Identities = 33/115 (28%), Positives = 57/115 (49%), Gaps = 11/115 (9%)

Query: 111 RDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDI-----DFREGDP 165
           +D V +G  + +A      + +G    P+ ++G    RL+G+VT RD+       R G  
Sbjct: 30  KDLVTVGESDDLALAESLLRLSGIRHLPVVKDG----RLVGLVTQRDVLRSGQSGRSGAR 85

Query: 166 HLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTD 220
            L++ EVMT   D+ T +    L  A  ++ + K G LP+ + +G LV ++   D
Sbjct: 86  TLAVSEVMT--RDLTTVRPATALSQAARLMLERKYGCLPVCDEEGRLVGIVTEAD 138


>UniRef50_Q3E1R1 Cluster: CBS; n=3; Bacteria|Rep: CBS - Chloroflexus
           aurantiacus J-10-fl
          Length = 155

 Score = 49.2 bits (112), Expect = 3e-04
 Identities = 28/111 (25%), Positives = 59/111 (53%), Gaps = 9/111 (8%)

Query: 111 RDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLK 170
           ++ VC+  +  V D      +N  +G P+       G L+G+VT  D+  +EG    ++K
Sbjct: 9   KNVVCVTDDAAVEDAARLMTRNRISGLPVVNPQ---GMLVGLVTEHDLIAKEG---RTVK 62

Query: 171 EVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
           E+MT    +I+      ++   ++L   +  ++P++ N G++V +++R+DL
Sbjct: 63  EIMT--RSVISVSPDTEVEQIQHLLTNQRIRRVPVVEN-GKVVGIVSRSDL 110


>UniRef50_Q2NBF2 Cluster: CBS; n=3; Bacteria|Rep: CBS -
           Erythrobacter litoralis (strain HTCC2594)
          Length = 147

 Score = 49.2 bits (112), Expect = 3e-04
 Identities = 30/122 (24%), Positives = 59/122 (48%), Gaps = 9/122 (7%)

Query: 106 KHGFIRDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFR---E 162
           K+    +P C  P  +V +      KN     P+  +    G L+G++T RDI  R   +
Sbjct: 4   KNVMTSNPACCNPSTSVREAANLMVKNDCGEIPVVDDS---GTLVGVITDRDIACRCVAD 60

Query: 163 G-DPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
           G     S+++VMT  +  IT     ++ D    +E +K  +LP+++  G+   ++++ D+
Sbjct: 61  GKSSDTSVEDVMT--SSPITVTPDTSVDDCRSKMEDNKVRRLPVVDESGKCCGIVSQADI 118

Query: 222 KK 223
            +
Sbjct: 119 AR 120


>UniRef50_Q898U3 Cluster: Inosine-5-monophosphate dehydrogenase
           related protein; n=3; Clostridium|Rep:
           Inosine-5-monophosphate dehydrogenase related protein -
           Clostridium tetani
          Length = 143

 Score = 48.8 bits (111), Expect = 3e-04
 Identities = 36/133 (27%), Positives = 66/133 (49%), Gaps = 15/133 (11%)

Query: 111 RDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFR-----EGDP 165
           +D V +  E+TV    +  K++G    PI   GK    ++GI+T RDI  R     E   
Sbjct: 9   KDIVSLQAEDTVEHAAQLMKEHGVGSLPICNEGK----IVGIITDRDIALRSVAMGESIQ 64

Query: 166 HLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKAR 225
           + +++ +MT  ++ IT    ++  +A  I+ K +  +LP++ N   LV +++  D+    
Sbjct: 65  NQTVRNIMT--SNPITVSPNISATEAAEIMSKKQIRRLPVVENK-NLVGMVSLGDIS--- 118

Query: 226 SYPNASKDSNKQL 238
           + PN    + K L
Sbjct: 119 TEPNLENSAGKAL 131


>UniRef50_Q8DLH3 Cluster: Tll0519 protein; n=4; Cyanobacteria|Rep:
           Tll0519 protein - Synechococcus elongatus
           (Thermosynechococcus elongatus)
          Length = 907

 Score = 48.4 bits (110), Expect = 4e-04
 Identities = 30/107 (28%), Positives = 52/107 (48%), Gaps = 9/107 (8%)

Query: 118 PENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDID--FREGDPHLSLKEVM-T 174
           PE  +AD      + G +G  +       G L+GI++ RD+D     G  H  +K  M  
Sbjct: 324 PETPIADAHRVLLRYGHSGLSVVS---AEGELLGIISRRDLDVALHHGFAHAPVKGYMKA 380

Query: 175 PINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
           P+    T      L +   ++ +   G+LP++N+ G+LV ++ RTD+
Sbjct: 381 PVR---TISPTTPLPEIQALMVQYDIGRLPVVNDQGDLVGIVTRTDV 424


>UniRef50_O66749 Cluster: Putative uncharacterized protein; n=1;
           Aquifex aeolicus|Rep: Putative uncharacterized protein -
           Aquifex aeolicus
          Length = 319

 Score = 48.4 bits (110), Expect = 4e-04
 Identities = 32/115 (27%), Positives = 53/115 (46%), Gaps = 6/115 (5%)

Query: 112 DPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLKE 171
           +P+ + P  T+ +V E   K+   G P+   GK    L+GIVT  DI     +     + 
Sbjct: 203 NPITVSPNQTLKEVEEILSKHLIGGLPVVAKGK----LVGIVTKSDIQKVPSELREKKRV 258

Query: 172 VMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDG--ELVALIARTDLKKA 224
                 ++IT     +L +   I      G+LP++ + G  EL+ +I R D+ KA
Sbjct: 259 YDVMSTNLITVTEEESLAEVLRIFSSKGIGRLPVVKHKGSSELIGIITRADIGKA 313


>UniRef50_A7RLX0 Cluster: Predicted protein; n=1; Nematostella
           vectensis|Rep: Predicted protein - Nematostella
           vectensis
          Length = 209

 Score = 48.4 bits (110), Expect = 4e-04
 Identities = 22/30 (73%), Positives = 26/30 (86%)

Query: 55  LLKAPLVSTPMDTVTEADMAISMALCGGIG 84
           LLK P VS+PMDTVTE+ MA++MAL GGIG
Sbjct: 154 LLKTPFVSSPMDTVTESAMAVAMALHGGIG 183


>UniRef50_UPI00015BB20C Cluster: putative signal transduction
           protein with CBS domains; n=1; Ignicoccus hospitalis
           KIN4/I|Rep: putative signal transduction protein with
           CBS domains - Ignicoccus hospitalis KIN4/I
          Length = 138

 Score = 47.6 bits (108), Expect = 8e-04
 Identities = 29/111 (26%), Positives = 58/111 (52%), Gaps = 6/111 (5%)

Query: 113 PVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDF--REGDPHLSLK 170
           P+ + P+ +V DV +   ++G+    + ++ KL    IGIVT RD+ +   EG+  + LK
Sbjct: 19  PLVVSPDESVVDVAKKMLEHGYGSALVIEDDKL----IGIVTERDLLYALSEGEEGVKLK 74

Query: 171 EVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
                  D I+ +    + +A  I++ +    LP++++ G  V ++A  D+
Sbjct: 75  ASDVMTEDPISVKAKTDIMEAIKIMKDANVRHLPVVDDKGRPVGVVAFRDI 125


>UniRef50_Q2JHW1 Cluster: PolyA polymerase family protein; n=3;
           Synechococcus|Rep: PolyA polymerase family protein -
           Synechococcus sp. (strain JA-2-3B'a(2-13))
           (Cyanobacteria bacteriumYellowstone B-Prime)
          Length = 908

 Score = 47.6 bits (108), Expect = 8e-04
 Identities = 31/106 (29%), Positives = 53/106 (50%), Gaps = 8/106 (7%)

Query: 118 PENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDID--FREGDPHLSLKEVMTP 175
           PE T+ +      + G +G  +       GRL+G+++ RDID     G  H  +K  MT 
Sbjct: 336 PEITIDEAQRVLLRYGHSGLVVVD---AQGRLVGVISRRDIDIALHHGFGHAPVKGYMT- 391

Query: 176 INDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
             D+ T      L +   ++ +   G+LP++  DG+LV ++ RTD+
Sbjct: 392 -TDVKTLSPDTPLAEIQRLMVQWDIGRLPVL-QDGQLVGIVTRTDV 435


>UniRef50_Q8TWX4 Cluster: Prdicted regulatory protein consisting of
           a uncharacterized conserved domain fused to a CBS
           domain; n=7; Euryarchaeota|Rep: Prdicted regulatory
           protein consisting of a uncharacterized conserved domain
           fused to a CBS domain - Methanopyrus kandleri
          Length = 501

 Score = 47.6 bits (108), Expect = 8e-04
 Identities = 28/108 (25%), Positives = 54/108 (50%), Gaps = 5/108 (4%)

Query: 114 VCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLKEVM 173
           V   P+ ++ DV     +      P+       GR++GIVTS DI     +    LK++M
Sbjct: 391 VTASPDESIEDVARRLIEKEINHIPVVDEE---GRIVGIVTSWDIAAAVAEGKRRLKDIM 447

Query: 174 TPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
           T   D+IT +   ++ +A   +++     LP+++ +  +V ++ RTD+
Sbjct: 448 T--EDVITIRPHESVDEALRRMDRHNISCLPVVDGENRVVGIVTRTDI 493


>UniRef50_Q8R911 Cluster: CBS domains; n=3; Thermoanaerobacter|Rep:
           CBS domains - Thermoanaerobacter tengcongensis
          Length = 435

 Score = 46.8 bits (106), Expect = 0.001
 Identities = 36/116 (31%), Positives = 56/116 (48%), Gaps = 8/116 (6%)

Query: 112 DPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLKE 171
           +PV M P+ TV D      +   T +P+  +    G L+G+VTSRD+     D  +   +
Sbjct: 196 NPVYMTPQQTVRDWKRLYAETKHTRFPVVDSK---GMLVGMVTSRDVATASDDDRIG--D 250

Query: 172 VMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKARSY 227
           +MTP    +T     TL  A +++       LP+     EL+ LI+R D+ KA  Y
Sbjct: 251 IMTPNPVFVTDT--TTLSYAAHLMIWWNVEILPVTRGK-ELIGLISREDVIKALHY 303


>UniRef50_Q6Q303 Cluster: IMP dehydrogenase; n=1; Synechococcus sp.
           PCC 7002|Rep: IMP dehydrogenase - Synechococcus sp.
           (strain PCC 7002) (Agmenellum quadruplicatum)
          Length = 258

 Score = 46.8 bits (106), Expect = 0.001
 Identities = 25/51 (49%), Positives = 32/51 (62%)

Query: 291 IQVVGGNVVTRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAV 341
           I VV GN VT   A  L+ AG  A+ VG+G G+ C ++ V+  G PQATAV
Sbjct: 188 IPVVLGNCVTYDAALELMRAGAAAVLVGIGPGAACTSRGVLGVGVPQATAV 238


>UniRef50_A0LGS9 Cluster: CBS domain containing membrane protein;
           n=1; Syntrophobacter fumaroxidans MPOB|Rep: CBS domain
           containing membrane protein - Syntrophobacter
           fumaroxidans (strain DSM 10017 / MPOB)
          Length = 225

 Score = 46.8 bits (106), Expect = 0.001
 Identities = 33/126 (26%), Positives = 61/126 (48%), Gaps = 20/126 (15%)

Query: 114 VCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDI--------------- 158
           V +GP + + +  E   K+ F   P+        RL+GIVT RDI               
Sbjct: 12  VTVGPNDGILETRELLAKSSFRHLPVVDEEN---RLVGIVTDRDIRSAMPSVFLDENETL 68

Query: 159 DFREGDPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIAR 218
             RE    + +K++MT   + +T     TL+DA  ++++ + G  P+++ +G+L  +++ 
Sbjct: 69  KERERLAQMKIKDIMT--KNPVTVNPANTLEDAILLMQRMRVGAFPVVDREGKLRGMLSI 126

Query: 219 TDLKKA 224
            DL +A
Sbjct: 127 RDLVRA 132


>UniRef50_Q96YR0 Cluster: Putative uncharacterized protein ST2113;
           n=2; Sulfolobaceae|Rep: Putative uncharacterized protein
           ST2113 - Sulfolobus tokodaii
          Length = 268

 Score = 46.8 bits (106), Expect = 0.001
 Identities = 38/172 (22%), Positives = 82/172 (47%), Gaps = 12/172 (6%)

Query: 59  PLVSTPMDTVTEADMAISMALCGGI-GIIHHNCTPEYQANEVHKVKKYKHGFIRDPVCMG 117
           PL ++ +    +A + I ++  G I G+I  +   +Y A  +  + K      ++P+ + 
Sbjct: 83  PLEASQIMIEKKAPLLIVISDTGKILGMIIKSDLAQYYATLIRGIHKVSEYMSKNPITVN 142

Query: 118 PENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDF-----REGDPHLSLKEV 172
            ++T+ +V +   +       +  NGK    ++G +T+ D+ +     +  D  + +KEV
Sbjct: 143 KDSTLDEVTKIILEKNIGRLIVEDNGK----ILGTITTTDLLYLAPVLKFKDLKIKVKEV 198

Query: 173 MTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKA 224
           MTP   ++       L  A  ++   K   +PI++ +GEL  ++  TD+ +A
Sbjct: 199 MTP--TIVVMDENEDLNYAAKLMANRKVKGIPIVSANGELKGIVTTTDIVRA 248


>UniRef50_Q9X175 Cluster: Inosine-5-monophosphate
           dehydrogenase-related protein; n=4; Thermotogaceae|Rep:
           Inosine-5-monophosphate dehydrogenase-related protein -
           Thermotoga maritima
          Length = 321

 Score = 46.4 bits (105), Expect = 0.002
 Identities = 30/112 (26%), Positives = 61/112 (54%), Gaps = 7/112 (6%)

Query: 112 DPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHL--SL 169
           D + + P+ T+  V E  +    +G P+  + K   R++GIV+  DI       ++  S+
Sbjct: 25  DVIYVTPDKTLLHVKEIMRIKRISGVPVVDDKK---RVVGIVSLEDIIKALEGSYIKDSV 81

Query: 170 KEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
           ++ MT   +++  +   TLQDA    EK   G+ P+++++G+LV ++ + D+
Sbjct: 82  EKRMT--KNVVCLKETDTLQDAVKTFEKYGYGRFPVVDDEGKLVGIVTKHDI 131


>UniRef50_A5IN38 Cluster: CBS domain containing protein; n=2;
           Thermotoga|Rep: CBS domain containing protein -
           Thermotoga petrophila RKU-1
          Length = 215

 Score = 46.4 bits (105), Expect = 0.002
 Identities = 31/127 (24%), Positives = 64/127 (50%), Gaps = 20/127 (15%)

Query: 111 RDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDP----- 165
           R+P+ + PE + ++ L+  K+N      + ++ K+    +GIVT +D+ +          
Sbjct: 9   RNPITIAPETSFSEALKLMKQNKIKRLIVMKDEKI----VGIVTEKDLLYASPSKATTLN 64

Query: 166 ---------HLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALI 216
                     L ++E+MT   +++T      ++DA  I+E+     LP++++ G LV +I
Sbjct: 65  IWELHYLLSKLKIEEIMT--KNVVTVNENAPIEDAARIMEEKDISGLPVVDDAGRLVGII 122

Query: 217 ARTDLKK 223
            +TD+ K
Sbjct: 123 TQTDIFK 129


>UniRef50_Q2ACR8 Cluster: CBS; n=1; Halothermothrix orenii H
           168|Rep: CBS - Halothermothrix orenii H 168
          Length = 262

 Score = 46.0 bits (104), Expect = 0.002
 Identities = 28/111 (25%), Positives = 56/111 (50%), Gaps = 7/111 (6%)

Query: 111 RDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLK 170
           +DP+ + PE TV +  +    N      + ++  L    +GI+T  D+  +  D +  + 
Sbjct: 9   KDPITISPETTVVEAEKLMSINNIGRLIVVEDEGL----VGILTDGDLVIQH-DLNAPID 63

Query: 171 EVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
           + M+   ++IT     T+Q+A  +L     G LP+++ DG+LV ++   D+
Sbjct: 64  KFMS--REVITISQNATVQEAAKVLSDHGIGGLPVLDEDGKLVGIVTADDI 112


>UniRef50_A4M812 Cluster: Polynucleotide adenylyltransferase region;
           n=1; Petrotoga mobilis SJ95|Rep: Polynucleotide
           adenylyltransferase region - Petrotoga mobilis SJ95
          Length = 885

 Score = 46.0 bits (104), Expect = 0.002
 Identities = 31/106 (29%), Positives = 56/106 (52%), Gaps = 9/106 (8%)

Query: 121 TVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDID--FREGDPHLSLKEVMTPIND 178
           TV    E   + G +G P+  + KL    +GIVT +DI+   + G  +  +K +M+   +
Sbjct: 335 TVEIAHELMFQTGHSGLPVISDNKL----VGIVTKKDIEKAMKHGLKNAPVKAIMS--TN 388

Query: 179 MITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKA 224
           +    +  +L     I+ ++  G++P++  DG LV +I RTDL +A
Sbjct: 389 LKVVDVETSLTQVRRIMAEADIGRIPVLK-DGILVGIITRTDLLRA 433


>UniRef50_O29915 Cluster: Putative uncharacterized protein; n=1;
           Archaeoglobus fulgidus|Rep: Putative uncharacterized
           protein - Archaeoglobus fulgidus
          Length = 362

 Score = 46.0 bits (104), Expect = 0.002
 Identities = 30/112 (26%), Positives = 61/112 (54%), Gaps = 9/112 (8%)

Query: 114 VCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLKEVM 173
           V + PE TV++V++   K    G+P+ +    G RL+GI+T  DI   E  P   +  +M
Sbjct: 243 VTVTPEMTVSEVIDLILKTKHLGFPVVE----GERLVGIITLHDIIGVE--PEERVGNIM 296

Query: 174 TPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKAR 225
           +   +++      +  +A  I+ +   G+LP++ + G +V +++R+DL + +
Sbjct: 297 S--REVVAVSPNQSAFEAFKIMSEMGIGRLPVVEH-GRVVGIVSRSDLMRIK 345


>UniRef50_Q7NVZ6 Cluster: Putative uncharacterized protein; n=3;
           Proteobacteria|Rep: Putative uncharacterized protein -
           Chromobacterium violaceum
          Length = 343

 Score = 45.6 bits (103), Expect = 0.003
 Identities = 26/82 (31%), Positives = 41/82 (50%)

Query: 320 GSGSICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQSVGHIIKSLALGASTVM 379
           G+ ++ +T    A      T +  + +  R  ++P++A GG      +I +LALGA  V 
Sbjct: 130 GADALLVTGHEAAAHGGSVTTLVLIPAIRRASSLPIVAAGGFADGAGLIAALALGADAVA 189

Query: 380 MGSLLAGTSEAPGEYFFSDGVR 401
           MGS LA T E+P      D +R
Sbjct: 190 MGSRLAMTRESPVHAQTKDMIR 211


>UniRef50_O26229 Cluster: Inosine-5'-monophosphate dehydrogenase
           related protein VII; n=2; Methanobacteriaceae|Rep:
           Inosine-5'-monophosphate dehydrogenase related protein
           VII - Methanobacterium thermoautotrophicum
          Length = 302

 Score = 45.6 bits (103), Expect = 0.003
 Identities = 30/113 (26%), Positives = 55/113 (48%), Gaps = 8/113 (7%)

Query: 111 RDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDI--DFREGDPHLS 168
           RD V + P+ TV +        G  G PI ++ ++ G    IVT  DI      G   + 
Sbjct: 188 RDLVTLAPDITVKEAAARLSSLGIEGAPIVEDDEVKG----IVTLSDITASIAAGTEFMQ 243

Query: 169 LKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
           + ++M+   ++IT +    + DA  ++ K   G+L + +++G    +I RTD+
Sbjct: 244 VSDIMS--KNIITVKQDTMIADAIEVMNKHNIGRLIVTDSEGRPTGIITRTDI 294


>UniRef50_A3CWH1 Cluster: CBS domain containing protein; n=1;
           Methanoculleus marisnigri JR1|Rep: CBS domain containing
           protein - Methanoculleus marisnigri (strain ATCC 35101 /
           DSM 1498 / JR1)
          Length = 251

 Score = 45.6 bits (103), Expect = 0.003
 Identities = 34/121 (28%), Positives = 59/121 (48%), Gaps = 11/121 (9%)

Query: 111 RDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLK 170
           R+PV   P+  V  +      +GFT +P+ Q  +     IGIV+ RD+  R G    S+K
Sbjct: 134 REPVTSTPDEPVHRIYSLIVASGFTAFPVVQKKE----TIGIVSRRDL-LRAGSVRTSVK 188

Query: 171 -EVMTPINDMITAQL-----GVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKA 224
            +  T +  ++T  +     G T+  A+ ++ +     LP+I+   +LV +I R D+   
Sbjct: 189 NQADTTVERVMTTPVISVTPGDTIATASRLMVEHDVSMLPVIDEKKQLVGVIDRHDVLSG 248

Query: 225 R 225
           R
Sbjct: 249 R 249


>UniRef50_A7HCW1 Cluster: Putative signal-transduction protein with
           CBS domains; n=2; Anaeromyxobacter|Rep: Putative
           signal-transduction protein with CBS domains -
           Anaeromyxobacter sp. Fw109-5
          Length = 145

 Score = 45.2 bits (102), Expect = 0.004
 Identities = 28/116 (24%), Positives = 58/116 (50%), Gaps = 9/116 (7%)

Query: 110 IRDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFR---EGDPH 166
           ++  +C  P++T  D     K+      PI          +G +T RD+  R   +G P 
Sbjct: 8   MKSAMCCRPDDTARDCARLMKEENIGFVPICNESD---EPVGTITDRDLALRILADGRPS 64

Query: 167 -LSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
              L  VMT   ++++ +LG  L+DA  ++ + +K ++ + + +G+L  +I+ +D+
Sbjct: 65  DAKLDGVMT--REVVSCRLGDDLRDAERLMREHRKSRIMVCDTEGKLQGVISLSDI 118


>UniRef50_A2ST08 Cluster: CBS domain containing protein; n=2;
           Methanomicrobiales|Rep: CBS domain containing protein -
           Methanocorpusculum labreanum (strain ATCC 43576 / DSM
           4855 / Z)
          Length = 512

 Score = 45.2 bits (102), Expect = 0.004
 Identities = 32/123 (26%), Positives = 61/123 (49%), Gaps = 8/123 (6%)

Query: 103 KKYKHGFIRDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFRE 162
           K+ +     D + +    TV DV+         G+P+ + GK+    +G +++RDI    
Sbjct: 4   KQVRDYMTHDVISIDASKTVGDVIRLIHTTDHDGFPVLRLGKV----VGYISARDII--- 56

Query: 163 GDPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLK 222
           G+ H S K  +      ITA+  VT+ +    + ++   KLP+I  D EL+ +I+  D+ 
Sbjct: 57  GE-HPSTKVELRMTRHPITARPDVTITEVARRIFRTGIQKLPVIGPDNELLGIISNMDVI 115

Query: 223 KAR 225
           +++
Sbjct: 116 RSQ 118


>UniRef50_A6SYJ5 Cluster: Inosine-5'-monophosphate dehydrogenase;
           n=1; Janthinobacterium sp. Marseille|Rep:
           Inosine-5'-monophosphate dehydrogenase -
           Janthinobacterium sp. (strain Marseille) (Minibacterium
           massiliensis)
          Length = 139

 Score = 44.8 bits (101), Expect = 0.006
 Identities = 32/114 (28%), Positives = 59/114 (51%), Gaps = 10/114 (8%)

Query: 112 DPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFR---EGDPHLS 168
           D   + PE T+ D  +  K+  F   P+ +N     R+IG ++ RDI  R   EG P  +
Sbjct: 11  DVQVISPEATIQDAAKKMKEGNFGMLPVHEND----RMIGSISDRDIVIRAVAEGKPSST 66

Query: 169 -LKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
            +++VMT    ++ A    +L +   ++ + +  +LPI+N+   LV ++A  D+
Sbjct: 67  KVRDVMT--KGIVWAFEDSSLSEGVRLMSQHQVRRLPIVNSQKRLVGIVAIGDV 118


>UniRef50_A5WFG6 Cluster: FMN-dependent alpha-hydroxy acid
           dehydrogenase; n=1; Psychrobacter sp. PRwf-1|Rep:
           FMN-dependent alpha-hydroxy acid dehydrogenase -
           Psychrobacter sp. PRwf-1
          Length = 352

 Score = 44.8 bits (101), Expect = 0.006
 Identities = 32/105 (30%), Positives = 48/105 (45%), Gaps = 7/105 (6%)

Query: 288 YPEIQVVGGNVVTRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASY 347
           Y  + V+   +V    A+  +D G   + V    G    T        P   A+ +VA  
Sbjct: 218 YTSLPVLIKGIVNAEDAQRALDIGASGIIVSNHGGRKLDTAP------PTIEALQRVAER 271

Query: 348 ARHFNVPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEAPG 392
             H  VPV+ DGGI+    ++K+LALGA  V++G  +A    A G
Sbjct: 272 VDH-RVPVLIDGGIRRGTDVLKALALGADAVLLGKPIAQALGAAG 315


>UniRef50_A1VAU2 Cluster: CBS domain containing protein; n=3;
           Desulfovibrio|Rep: CBS domain containing protein -
           Desulfovibrio vulgaris subsp. vulgaris (strain DP4)
          Length = 256

 Score = 44.8 bits (101), Expect = 0.006
 Identities = 33/129 (25%), Positives = 63/129 (48%), Gaps = 23/129 (17%)

Query: 111 RDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDP----- 165
           R+ + + P+ ++    +  K+NGF   P+       G+LIGIV+ RDI  +E  P     
Sbjct: 38  RNVITVTPDTSMMKASKLMKENGFRRLPVLDGN---GKLIGIVSDRDI--KEASPSKATT 92

Query: 166 -----------HLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVA 214
                       + +K++MT   D I  Q   T++    ++ +   G +P+++ +G+LV 
Sbjct: 93  LDMHELYYLLSEIKVKDIMT--RDPICVQPDETVERVALLMIEKHIGGMPVVDEEGQLVG 150

Query: 215 LIARTDLKK 223
           +I  +D+ K
Sbjct: 151 IITDSDIFK 159



 Score = 35.5 bits (78), Expect = 3.4
 Identities = 19/55 (34%), Positives = 27/55 (49%), Gaps = 3/55 (5%)

Query: 104 KYKHGFIRDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDI 158
           K K    RDP+C+ P+ TV  V     +    G P+       G+L+GI+T  DI
Sbjct: 106 KVKDIMTRDPICVQPDETVERVALLMIEKHIGGMPVVDE---EGQLVGIITDSDI 157


>UniRef50_A7D0I7 Cluster: Peptidase M50; n=4; Halobacteriaceae|Rep:
           Peptidase M50 - Halorubrum lacusprofundi ATCC 49239
          Length = 394

 Score = 44.8 bits (101), Expect = 0.006
 Identities = 28/106 (26%), Positives = 55/106 (51%), Gaps = 4/106 (3%)

Query: 119 ENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLKEVMTPIND 178
           + +VAD++    +   TGYP+   G L G ++ +  +R +   E D +  + +VM    +
Sbjct: 266 DTSVADLMSRMFEERHTGYPVLHGGNLVG-MVTLEDARSVRDVERDAY-QVADVME--TE 321

Query: 179 MITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKA 224
           ++          A   ++++  G+LP+++   ELV LI+R+DL  A
Sbjct: 322 VVGVGPEADAMTALQTMQENGVGRLPVVDRSDELVGLISRSDLMTA 367


>UniRef50_A0B5X6 Cluster: Putative signal-transduction protein with
           CBS domains; n=1; Methanosaeta thermophila PT|Rep:
           Putative signal-transduction protein with CBS domains -
           Methanosaeta thermophila (strain DSM 6194 / PT)
           (Methanothrixthermophila (strain DSM 6194 / PT))
          Length = 185

 Score = 44.8 bits (101), Expect = 0.006
 Identities = 31/86 (36%), Positives = 48/86 (55%), Gaps = 7/86 (8%)

Query: 146 GGRLIGIVTSRD----IDFREGDPHLS-LKEVMTPINDMITAQLGVTLQDANYILEKSKK 200
           G + IGI+T RD    +  R  DP  S + +VM   + +I      +L+DA  ++ KS  
Sbjct: 44  GAKPIGIITERDLVKKVVARAEDPRKSRVGDVMN--SPLIKIHPDASLRDAAELMLKSGV 101

Query: 201 GKLPIINNDGELVALIARTDLKKARS 226
            +LP+I++DG+LV +I  TDL    S
Sbjct: 102 KRLPVISDDGKLVGIITDTDLVSGAS 127


>UniRef50_Q67L31 Cluster: Glycine betaine/carnitine/choline ABC
           transporter ATP-binding protein; n=4; Firmicutes|Rep:
           Glycine betaine/carnitine/choline ABC transporter
           ATP-binding protein - Symbiobacterium thermophilum
          Length = 376

 Score = 44.4 bits (100), Expect = 0.007
 Identities = 32/112 (28%), Positives = 52/112 (46%), Gaps = 6/112 (5%)

Query: 110 IRDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSL 169
           I DPV  GPE  +A+ +   ++       +       GRL+GIVT+R ++ R    H +L
Sbjct: 256 IPDPVTAGPEYGIAEAVATMRRRRVNSVLVVDGD---GRLLGIVTARAVE-RGLASHRTL 311

Query: 170 KEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
            E+M      +     VT      +LE+ +   LP+++  G L  L+  T L
Sbjct: 312 GEIMETRLTTVLPHQPVTHAVQRMLLERLE--FLPVVDEQGRLQGLVTNTSL 361


>UniRef50_Q3AFS5 Cluster: CBS/GGDEF domain protein; n=1;
           Carboxydothermus hydrogenoformans Z-2901|Rep: CBS/GGDEF
           domain protein - Carboxydothermus hydrogenoformans
           (strain Z-2901 / DSM 6008)
          Length = 271

 Score = 44.4 bits (100), Expect = 0.007
 Identities = 32/122 (26%), Positives = 61/122 (50%), Gaps = 8/122 (6%)

Query: 102 VKKYKHGFIRDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFR 161
           +K+ +    R+PV + P  ++ D  E  +     G P+ +N K    LIGI+TS+D+ F 
Sbjct: 2   IKQVREVMTRNPVTIEPYRSLWDAKELMRSQRIGGLPVVENEK----LIGIITSKDLIFY 57

Query: 162 EGDPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
             +  L + + MT   + +  +    L DA   + ++   +LP+I+  G L  +I R  +
Sbjct: 58  P-ENRLVI-DAMT--EEPVVIEEKAYLFDAYQKMLENNIERLPVIDESGALTGIITRKVI 113

Query: 222 KK 223
           ++
Sbjct: 114 ER 115


>UniRef50_A5N386 Cluster: Putative uncharacterized protein; n=1;
           Clostridium kluyveri DSM 555|Rep: Putative
           uncharacterized protein - Clostridium kluyveri DSM 555
          Length = 141

 Score = 44.4 bits (100), Expect = 0.007
 Identities = 27/120 (22%), Positives = 60/120 (50%), Gaps = 7/120 (5%)

Query: 104 KYKHGFIRDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREG 163
           K ++   +    + P++T+    +   +N     P+ Q GK+    IGI+T RDI  R  
Sbjct: 2   KVENVMTKSVASLNPDDTIDKAAQVMMENNIGSLPVCQQGKI----IGILTDRDISIRAM 57

Query: 164 DPHLSLKEVMTPI--NDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
               S  + +  I  ++ +TA   + ++D + I+ + +  ++P++ N+  +V +++  DL
Sbjct: 58  GNKASNSKTVRDIMSSNPVTASPDMDVKDVSRIMSERQIRRVPVVENN-NVVGIVSLGDL 116


>UniRef50_A2SQ80 Cluster: CBS domain containing protein; n=4;
           Methanomicrobiales|Rep: CBS domain containing protein -
           Methanocorpusculum labreanum (strain ATCC 43576 / DSM
           4855 / Z)
          Length = 284

 Score = 44.4 bits (100), Expect = 0.007
 Identities = 29/98 (29%), Positives = 53/98 (54%), Gaps = 7/98 (7%)

Query: 124 DVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLKEVMTPINDMITAQ 183
           DVL   K+ G +G P+ +  +   +L+GIVT +DI  +  +  ++L     P+    T +
Sbjct: 25  DVLRILKRTGISGVPVVKGPEK--KLLGIVTRKDILRKPEETQVALLMSSEPL----TIR 78

Query: 184 LGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
             VTL +A  I+ K    +LP++  D  L+ +++ +DL
Sbjct: 79  PEVTLSEAAEIMTKMNVRRLPVVEGD-NLIGILSVSDL 115


>UniRef50_A2BJ31 Cluster: Predicted transcriptional regulator; n=1;
           Hyperthermus butylicus DSM 5456|Rep: Predicted
           transcriptional regulator - Hyperthermus butylicus
           (strain DSM 5456 / JCM 9403)
          Length = 296

 Score = 44.4 bits (100), Expect = 0.007
 Identities = 31/112 (27%), Positives = 57/112 (50%), Gaps = 7/112 (6%)

Query: 114 VCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDID--FREGDPHLSLKE 171
           + + P+ T+ D  +   +    G P+  +    GRLIGI+T  DI     EG    ++KE
Sbjct: 184 ITIEPDATIKDAAKLMIERRVKGLPVIDSR---GRLIGIITQTDIAKAVAEGRIDATVKE 240

Query: 172 VMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKK 223
            M+    +IT +    + DA  ++     G+L + +++G+ + +I RTD+ K
Sbjct: 241 YMS--FPVITIRSDEDIGDAIELMNLRDIGRLVVTDSEGKPIGIITRTDILK 290



 Score = 39.9 bits (89), Expect = 0.16
 Identities = 27/81 (33%), Positives = 48/81 (59%), Gaps = 7/81 (8%)

Query: 145 LGGRLIGIVTSRDIDFREGDPHLSLKEVMTPINDMITAQLGVTLQDA-NYILEKSKKGKL 203
           L  + IGI  +R I      P + + E+ + I ++IT +   T++DA   ++E+  KG L
Sbjct: 154 LATKQIGIKITRLISV----PRIPVGEIAS-IGNIITIEPDATIKDAAKLMIERRVKG-L 207

Query: 204 PIINNDGELVALIARTDLKKA 224
           P+I++ G L+ +I +TD+ KA
Sbjct: 208 PVIDSRGRLIGIITQTDIAKA 228


>UniRef50_Q9WZH4 Cluster: TRNA nucleotidyl transferase-related
           protein; n=2; Thermotoga|Rep: TRNA nucleotidyl
           transferase-related protein - Thermotoga maritima
          Length = 863

 Score = 44.0 bits (99), Expect = 0.010
 Identities = 27/106 (25%), Positives = 56/106 (52%), Gaps = 9/106 (8%)

Query: 121 TVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDID--FREGDPHLSLKEVMTPIND 178
           T+ +V    K+ G +G+P+ +    G RL+GIVT + ++     G     +K +M+   +
Sbjct: 320 TIKEVDRLMKQTGHSGFPVVE----GNRLVGIVTKKAVEKAMNHGLGDRPVKSIMS--TN 373

Query: 179 MITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKA 224
           ++ A     +     ++ +   G++PI+ N G LV ++ R+D+ +A
Sbjct: 374 LVVASPDTPVTRLRELMVEHAIGRIPILEN-GILVGIVTRSDVLRA 418


>UniRef50_A1CVD5 Cluster: 2-nitropropane dioxygenase family
           oxidoreductase, putative; n=1; Neosartorya fischeri NRRL
           181|Rep: 2-nitropropane dioxygenase family
           oxidoreductase, putative - Neosartorya fischeri (strain
           ATCC 1020 / DSM 3700 / NRRL 181)(Aspergillus
           fischerianus (strain ATCC 1020 / DSM 3700 / NRRL 181))
          Length = 345

 Score = 44.0 bits (99), Expect = 0.010
 Identities = 49/168 (29%), Positives = 77/168 (45%), Gaps = 15/168 (8%)

Query: 233 DSNKQLLVGAAIGTR--DTDRERLKLLVNNGVDVIVLDSSQGNSTYQIKMIKYIKETYPE 290
           DSN  L +G    T   DT ++    LVN    V V   +  + +   ++I+ ++ T  +
Sbjct: 77  DSNTLLPIGIGCLTMKSDTWKDNFVQLVNEYRPVAVWLFAYTHRSQHAELIQALQNTGKD 136

Query: 291 --IQVVGGNVVTRMQAKNLIDAGVDALRV-GMGSGSICITQEVMACGCPQATAVYQVASY 347
             ++V+   V T   A+  ID G D L V G  +G     Q     G    T + +VA  
Sbjct: 137 WGLKVIV-QVGTVESAREAIDDGADILSVQGSDAGGHQFKQ-----GASLMTLLPEVADM 190

Query: 348 AR----HFNVPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEAP 391
            R      N+P++A GGI     +  +L LGAS ++MG+    T+E P
Sbjct: 191 VRSEYPEKNIPLLAAGGIMDGRGVAAALMLGASGIVMGTGFLCTTECP 238


>UniRef50_A2BLX1 Cluster: Conserved archaeal protein; n=1;
           Hyperthermus butylicus DSM 5456|Rep: Conserved archaeal
           protein - Hyperthermus butylicus (strain DSM 5456 / JCM
           9403)
          Length = 153

 Score = 44.0 bits (99), Expect = 0.010
 Identities = 35/109 (32%), Positives = 55/109 (50%), Gaps = 10/109 (9%)

Query: 118 PENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFR---EG-DPHLSL-KEV 172
           P++TV D      K    G  +  + K  G ++GI+T  DI  R    G DP  +L ++V
Sbjct: 27  PDDTVVDAARKMAKYSI-GSVVVVDDK--GTILGILTEGDIVRRVVARGLDPSRTLVRDV 83

Query: 173 MTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
           MT   + +T     TL  A   +++   G LP++N  G LV +I +TD+
Sbjct: 84  MT--TNPVTIYSDATLAAAAEYMKRKGIGHLPVVNEQGRLVGIITKTDI 130


>UniRef50_Q67NF3 Cluster: Putative poly A polymerase; n=1;
           Symbiobacterium thermophilum|Rep: Putative poly A
           polymerase - Symbiobacterium thermophilum
          Length = 890

 Score = 43.6 bits (98), Expect = 0.013
 Identities = 27/102 (26%), Positives = 51/102 (50%), Gaps = 8/102 (7%)

Query: 122 VADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDID--FREGDPHLSLKEVMTPINDM 179
           + D      ++G TG P+       GR++G+V+ RD++   R G  H  +K VM   + +
Sbjct: 338 IRDAERLMLRHGHTGLPVVDEQ---GRVVGVVSLRDVEKARRHGLEHAPVKSVMR--SQV 392

Query: 180 ITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
           I         +   ++ +   G++P++  DG LV +I R+D+
Sbjct: 393 IAVHPDTPADEVQELMIERDIGRVPVV-ADGNLVGIITRSDI 433


>UniRef50_A5V6U0 Cluster: FMN-dependent alpha-hydroxy acid
           dehydrogenase; n=1; Sphingomonas wittichii RW1|Rep:
           FMN-dependent alpha-hydroxy acid dehydrogenase -
           Sphingomonas wittichii RW1
          Length = 395

 Score = 43.6 bits (98), Expect = 0.013
 Identities = 35/115 (30%), Positives = 56/115 (48%), Gaps = 8/115 (6%)

Query: 279 KMIKYIKETYPEIQVVGGNVVTRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQA 338
           K I +++  +    V+ G ++ R  A   +DAG DAL V    G        +    P A
Sbjct: 239 KDIAWLRNQWKGRLVIKG-ILDRRDATMALDAGADALVVSNHGG------RQLDGVAPTA 291

Query: 339 TAVYQVASYARHFNVPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEAPGE 393
            A+  +A  A     P++ DGG++S   ++K+L LGA  V++G   A  + A GE
Sbjct: 292 VALPAIAR-AVGGRAPLLVDGGVRSGQDVLKALLLGADGVLIGRAWAYAAAAGGE 345


>UniRef50_A1HPJ0 Cluster: Sigma54 specific transcriptional
           regulator, Fis family; n=6; Bacteria|Rep: Sigma54
           specific transcriptional regulator, Fis family -
           Thermosinus carboxydivorans Nor1
          Length = 700

 Score = 43.6 bits (98), Expect = 0.013
 Identities = 43/162 (26%), Positives = 69/162 (42%), Gaps = 9/162 (5%)

Query: 114 VCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVT-SRDIDFREGDPHLSLK-- 170
           V + P  T+          G  G P+       G+LIG+VT S  I     D   +L+  
Sbjct: 12  VTVTPGMTLQQTARIFDSVGIDGAPVVD---ANGKLIGLVTKSHLIKALAADNFYNLRVG 68

Query: 171 EVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKARSYPNA 230
           +VMTP  D+ T Q   T+Q+        + G+ P+++ +   +  I RTDL K  S  + 
Sbjct: 69  DVMTP--DVFTLQENTTIQELQQNNRIFRYGRFPVVDGENRPIGFITRTDLVKYLSERSL 126

Query: 231 -SKDSNKQLLVGAAIGTRDTDRERLKLLVNNGVDVIVLDSSQ 271
              D  + +L     G   T+ + +  L N   + I   SS+
Sbjct: 127 FLADEMQAVLNSVCNGVIVTNADGIVTLFNPAAEYITGLSSE 168


>UniRef50_Q0W4Y8 Cluster: Putative uncharacterized protein; n=1;
           uncultured methanogenic archaeon RC-I|Rep: Putative
           uncharacterized protein - Uncultured methanogenic
           archaeon RC-I
          Length = 138

 Score = 43.6 bits (98), Expect = 0.013
 Identities = 34/125 (27%), Positives = 65/125 (52%), Gaps = 11/125 (8%)

Query: 104 KYKHGFIRDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFR-- 161
           K K     +  C+  ++T AD   AK KN  TG  I  +G     + GIVT R I  +  
Sbjct: 2   KIKDVMTSEIACVDTKSTAADAA-AKMKNQNTGTVIVVDGD---SVKGIVTDRQIAIKAV 57

Query: 162 --EGDP-HLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIAR 218
             + DP +  + ++MT   D++  +    + DA   + ++K  +LP++N++ +LV +++ 
Sbjct: 58  AEKKDPKNTPVSDIMT--KDIVGCRENDDIFDALKTMGENKVRRLPVVNDNSQLVGIVSI 115

Query: 219 TDLKK 223
           +D+ +
Sbjct: 116 SDIAR 120


>UniRef50_Q835K5 Cluster: CBS domain protein; n=6; Bacilli|Rep: CBS
           domain protein - Enterococcus faecalis (Streptococcus
           faecalis)
          Length = 439

 Score = 43.2 bits (97), Expect = 0.017
 Identities = 29/104 (27%), Positives = 56/104 (53%), Gaps = 7/104 (6%)

Query: 121 TVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLKEVMTPINDMI 180
           T+AD     +    + +P+  N KL  RL+GIVT++D+  +    HL++ +VMT   +++
Sbjct: 209 TIADYQALSESTHHSRFPVV-NKKL--RLVGIVTAKDVIGK--SEHLTVDKVMTKDPNVV 263

Query: 181 TAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKA 224
              + V       I +  +   +P++ +D  LV +++R D+ KA
Sbjct: 264 KKMMSVASVSHQMIWDGLE--VMPVVEDDLALVGIVSRQDVMKA 305


>UniRef50_Q1IKU8 Cluster: 2-nitropropane dioxygenase, NPD; n=2;
           Bacteria|Rep: 2-nitropropane dioxygenase, NPD -
           Acidobacteria bacterium (strain Ellin345)
          Length = 356

 Score = 43.2 bits (97), Expect = 0.017
 Identities = 39/118 (33%), Positives = 55/118 (46%), Gaps = 4/118 (3%)

Query: 275 TYQIKMIKYIKETYPEIQVVGGNVVTRMQAKNLIDAGVDALRV-GMGSGSICITQEV-MA 332
           T+ I +   I+       +V G   T  + + L  AGVDA+   G  +G    T +V   
Sbjct: 131 TFGIPLASAIQRAQKRGILVFGTATTVREGQLLASAGVDAIVAQGAEAGGQRGTFDVSFE 190

Query: 333 CGCPQATAVYQVASYARHFNVPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEA 390
            G     A+  VA  A    +PVIA GGI +   I + L LGAS V +G++   T EA
Sbjct: 191 EGLVPLRAL--VAGLANAVALPVIASGGIMNGREIAEMLRLGASAVQLGTVFLCTPEA 246


>UniRef50_A5D444 Cluster: Putative uncharacterized protein; n=1;
           Pelotomaculum thermopropionicum SI|Rep: Putative
           uncharacterized protein - Pelotomaculum
           thermopropionicum SI
          Length = 281

 Score = 43.2 bits (97), Expect = 0.017
 Identities = 30/102 (29%), Positives = 55/102 (53%), Gaps = 9/102 (8%)

Query: 120 NTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLKEVMTPINDM 179
           ++VA      +K+G  G P+  + KL     GI+TSRD+  R   P+  + + M+   ++
Sbjct: 19  DSVAKAALLMEKHGIGGLPVLNDDKL----CGIITSRDV--RRAHPNRIVADAMS--KNV 70

Query: 180 ITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
           I+     +L +A  I+ + K  +LP++  D  LV +I +TD+
Sbjct: 71  ISVNSNESLLNAMNIIGEKKVERLPVL-EDCRLVGIITKTDI 111


>UniRef50_Q2H129 Cluster: Putative uncharacterized protein; n=1;
           Chaetomium globosum|Rep: Putative uncharacterized
           protein - Chaetomium globosum (Soil fungus)
          Length = 249

 Score = 43.2 bits (97), Expect = 0.017
 Identities = 24/60 (40%), Positives = 33/60 (55%)

Query: 310 AGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQSVGHIIK 369
           AG++ L++GMG GS CI QEVM        A   V  +A +   P +  G IQ+VG + K
Sbjct: 83  AGLEGLKIGMGRGSACIIQEVMKVRLLPGEAGDSVPPFAGNPAKPKVRVGSIQNVGPMDK 142


>UniRef50_Q8TX12 Cluster: CBS-domain-containing protein; n=3;
           Euryarchaeota|Rep: CBS-domain-containing protein -
           Methanopyrus kandleri
          Length = 138

 Score = 43.2 bits (97), Expect = 0.017
 Identities = 25/65 (38%), Positives = 39/65 (60%), Gaps = 2/65 (3%)

Query: 160 FREGDPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIART 219
           FRE      ++E+MT   D ITA   V + +A  I+ K   G LP+++++G L+ L+ RT
Sbjct: 3   FREKLRGCKVEELMT--KDPITASPQVGVIEAFEIMLKHDVGALPVVDDEGRLIGLVTRT 60

Query: 220 DLKKA 224
           DL +A
Sbjct: 61  DLGRA 65



 Score = 40.3 bits (90), Expect = 0.12
 Identities = 30/118 (25%), Positives = 59/118 (50%), Gaps = 12/118 (10%)

Query: 111 RDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFR----EGDPH 166
           +DP+   P+  V +  E   K+     P+  +    GRLIG+VT  D+       E +P 
Sbjct: 18  KDPITASPQVGVIEAFEIMLKHDVGALPVVDDE---GRLIGLVTRTDLGRALLEDEYEPG 74

Query: 167 LSLKEVMTPINDMITAQLGVTLQDANYILEKSKKG---KLPIINNDGELVALIARTDL 221
            +++EVM    D++      TL +A   +  + +G   +LP+++++ +LV ++   D+
Sbjct: 75  TTVEEVME--RDVVVVHPDDTLLEALKRMTSAPEGIYNQLPVVDDEEKLVGILTDGDI 130


>UniRef50_Q57976 Cluster: Methylated protein MJ0556; n=2;
           Methanocaldococcus jannaschii|Rep: Methylated protein
           MJ0556 - Methanococcus jannaschii
          Length = 174

 Score = 43.2 bits (97), Expect = 0.017
 Identities = 36/143 (25%), Positives = 62/143 (43%), Gaps = 11/143 (7%)

Query: 98  EVHKVKKYKHGFIRDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRD 157
           E+ K++        D +   PE T+ ++ +   K+  +G P+  +    G +IG +T R+
Sbjct: 18  ELQKIRVKDVMISGDVIITTPEKTIKEIFDEMIKHNISGMPVVDD---RGVMIGFITLRE 74

Query: 158 I-DFREGDPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINND------G 210
           I  +    P+L++ EVM       TA   +       I    K  +LP+IN        G
Sbjct: 75  IRKYMTSHPYLNVGEVMLKNPPYTTADEDIITAFEKMIESNKKLDQLPVINTKYPEKILG 134

Query: 211 ELVALIARTDLKKARSYPNASKD 233
           +L  +I   D+ K   Y N  K+
Sbjct: 135 KLEGIIFMEDIIKL-LYENIIKE 156


>UniRef50_Q97M06 Cluster: Deoxyphosphogluconate aldolase; n=1;
           Clostridium acetobutylicum|Rep: Deoxyphosphogluconate
           aldolase - Clostridium acetobutylicum
          Length = 208

 Score = 42.7 bits (96), Expect = 0.022
 Identities = 31/102 (30%), Positives = 44/102 (43%), Gaps = 3/102 (2%)

Query: 255 KLLVNNGVDVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVVTRMQAKNLIDAGVDA 314
           K L++ G+D I +  S  ++    K+IK +K+ YP   +  G VVT  QAK  ID G D 
Sbjct: 31  KRLISQGIDTIEVTYSVKDAG---KLIKALKDEYPNSLIGAGTVVTAAQAKEAIDYGADF 87

Query: 315 LRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFNVPVI 356
           +        +C         C Q TA    A  A      +I
Sbjct: 88  IVSPCIVEEVCEYCVKNDIACSQGTATPTEAFKAASLGADII 129


>UniRef50_Q5WEY2 Cluster: Putative uncharacterized protein; n=1;
           Bacillus clausii KSM-K16|Rep: Putative uncharacterized
           protein - Bacillus clausii (strain KSM-K16)
          Length = 698

 Score = 42.7 bits (96), Expect = 0.022
 Identities = 29/110 (26%), Positives = 59/110 (53%), Gaps = 8/110 (7%)

Query: 122 VADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDI-DFRE-GDPHLSLKEVMTPINDM 179
           + +V +   ++G +G+P+       G L G++T  D+   R+ G     + EVM+  N  
Sbjct: 195 IDEVWQTLLRSGHSGFPVVDET---GALAGVITRMDLAKARQFGMGEAQVTEVMSMPN-- 249

Query: 180 ITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKARSYPN 229
           IT +   ++  A   L  ++ G+LP++ ++ E + ++ RTD+ ++  YPN
Sbjct: 250 ITLRANDSIDAACAHLAYNQVGRLPVVGDNNEPIGIVTRTDIVRS-LYPN 298


>UniRef50_Q3JCC7 Cluster: Peptidase M50; n=1; Nitrosococcus oceani
           ATCC 19707|Rep: Peptidase M50 - Nitrosococcus oceani
           (strain ATCC 19707 / NCIMB 11848)
          Length = 404

 Score = 42.7 bits (96), Expect = 0.022
 Identities = 32/113 (28%), Positives = 56/113 (49%), Gaps = 4/113 (3%)

Query: 112 DPVCMGPENTVADVLEAK-KKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLK 170
           D V + P+  V  ++E    ++    +P+ +N +L G +I I   R I  RE     ++ 
Sbjct: 274 DFVKVNPDMRVRTLVEEHLMRSDQRAFPVEENNRLAG-IISIPDIRKIS-REKWSQTTIG 331

Query: 171 EVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKK 223
           E+MTP+  +          +A +IL +    +LP++ N G++  LI R DL K
Sbjct: 332 ELMTPVRKVALTSPKGGAAEALFILARRNINQLPVVEN-GQIRGLIRREDLLK 383


>UniRef50_Q0SD75 Cluster: Possible nitropropane dioxygenase; n=1;
           Rhodococcus sp. RHA1|Rep: Possible nitropropane
           dioxygenase - Rhodococcus sp. (strain RHA1)
          Length = 266

 Score = 42.7 bits (96), Expect = 0.022
 Identities = 19/48 (39%), Positives = 30/48 (62%)

Query: 344 VASYARHFNVPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEAP 391
           + + AR   +P+IA GG  +   ++ +LALGAS V MG+    ++EAP
Sbjct: 94  IPAAARQVRIPLIASGGFATGSGLVAALALGASAVNMGTRFVASTEAP 141


>UniRef50_Q0SD94 Cluster: Possible 2-nitropropane dioxygenase; n=74;
           cellular organisms|Rep: Possible 2-nitropropane
           dioxygenase - Rhodococcus sp. (strain RHA1)
          Length = 334

 Score = 42.7 bits (96), Expect = 0.022
 Identities = 19/48 (39%), Positives = 30/48 (62%)

Query: 344 VASYARHFNVPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEAP 391
           + + AR   +P+IA GG  +   ++ +LALGAS V MG+    ++EAP
Sbjct: 162 IPAAARQVRIPLIASGGFATGSGLVAALALGASAVNMGTRFVASTEAP 209


>UniRef50_A4J1P0 Cluster: Putative signal-transduction protein with
           CBS domains; n=3; Firmicutes|Rep: Putative
           signal-transduction protein with CBS domains -
           Desulfotomaculum reducens MI-1
          Length = 145

 Score = 42.7 bits (96), Expect = 0.022
 Identities = 28/137 (20%), Positives = 64/137 (46%), Gaps = 12/137 (8%)

Query: 103 KKYKHGFIRDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFR- 161
           +K K    ++   + P+ ++ +  +   ++     P+ +NG      +GIVT RDI  R 
Sbjct: 3   QKLKEIMTQNIATVSPQQSIQEATQLMSQHNVGSIPVVENGNC----VGIVTDRDIALRA 58

Query: 162 ----EGDPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIA 217
               +     +++ VMT  + ++T    + + +A  ++ + +  +LP++ N G +  ++A
Sbjct: 59  VSQGQNPSSTTVQSVMT--SGVVTGSPEMDVHEAANLMAERQVRRLPVVEN-GSITGMVA 115

Query: 218 RTDLKKARSYPNASKDS 234
             DL     Y N +  +
Sbjct: 116 LGDLATQNIYQNEASQA 132


>UniRef50_Q2FT94 Cluster: Putative signal-transduction protein with
           CBS domains; n=3; Methanomicrobiales|Rep: Putative
           signal-transduction protein with CBS domains -
           Methanospirillum hungatei (strain JF-1 / DSM 864)
          Length = 188

 Score = 42.7 bits (96), Expect = 0.022
 Identities = 26/82 (31%), Positives = 49/82 (59%), Gaps = 11/82 (13%)

Query: 147 GRLIGIVTSRDI-------DFREGDPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSK 199
           G  +GIVT +DI       D R  + H+S  E+MT  + +IT     T++DA +++ +++
Sbjct: 55  GVAVGIVTEQDINCKVVARDLRPSEVHVS--EIMT--SPLITIGTDKTVEDAAHLMIRNR 110

Query: 200 KGKLPIINNDGELVALIARTDL 221
             +LPIIN+ G ++ +++  D+
Sbjct: 111 VRRLPIINDKGVVIGIVSVRDI 132


>UniRef50_Q1D9V2 Cluster: CBS domain protein; n=1; Myxococcus
           xanthus DK 1622|Rep: CBS domain protein - Myxococcus
           xanthus (strain DK 1622)
          Length = 138

 Score = 42.3 bits (95), Expect = 0.029
 Identities = 26/81 (32%), Positives = 47/81 (58%), Gaps = 7/81 (8%)

Query: 146 GGRLIGIVTSRDIDFREG----DPHLS-LKEVMTPINDMITAQLGVTLQDANYILEKSKK 200
           GG+L+G++T RDI  R      DP+ + ++EVMT    +IT  +  TL+ A  ++E+   
Sbjct: 40  GGQLVGMLTDRDIAVRSAALGQDPNTTPVREVMTA--TVITCDVDATLEVAEKVMEEKMV 97

Query: 201 GKLPIINNDGELVALIARTDL 221
            +L +++ +   V L++  DL
Sbjct: 98  RRLVVVDGERRPVGLLSLDDL 118


>UniRef50_A7HHL2 Cluster: Putative CBS domain and cyclic
           nucleotide-regulated nucleotidyltransferase; n=1;
           Anaeromyxobacter sp. Fw109-5|Rep: Putative CBS domain
           and cyclic nucleotide-regulated nucleotidyltransferase -
           Anaeromyxobacter sp. Fw109-5
          Length = 641

 Score = 41.9 bits (94), Expect = 0.039
 Identities = 28/80 (35%), Positives = 44/80 (55%), Gaps = 6/80 (7%)

Query: 146 GGRLIGIVTSRDIDFR---EG-DPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKG 201
           GG L+G+V+ RD+  R    G D    + EVMTP  + + A  G+ L +A  ++ +S   
Sbjct: 211 GGALVGVVSERDLVERALANGLDAARPVSEVMTPAGEPMPA--GLALAEAMEVMVRSGVR 268

Query: 202 KLPIINNDGELVALIARTDL 221
            L +  + GE+V L+A  DL
Sbjct: 269 SLAVAGDRGEIVGLLADDDL 288


>UniRef50_A6GTG2 Cluster: Putative uncharacterized protein; n=1;
           Limnobacter sp. MED105|Rep: Putative uncharacterized
           protein - Limnobacter sp. MED105
          Length = 362

 Score = 41.9 bits (94), Expect = 0.039
 Identities = 30/98 (30%), Positives = 50/98 (51%), Gaps = 7/98 (7%)

Query: 295 GGNV-VTRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFNV 353
           GG V VT + AK+ + A         G+ ++ +T    A      T++  V +  +   +
Sbjct: 110 GGKVIVTVVNAKHALKAEQS------GADALLVTGHEAAAHGGAVTSLVLVPAIRQVTKL 163

Query: 354 PVIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEAP 391
           P+IA GG  + G ++ +LALGA  V MG+  A + E+P
Sbjct: 164 PIIAAGGFGTGGGVVAALALGADGVAMGTRWAASKESP 201



 Score = 35.9 bits (79), Expect = 2.6
 Identities = 19/55 (34%), Positives = 31/55 (56%), Gaps = 1/55 (1%)

Query: 50  LTKKILLKAPLVSTPMDTVTEADMAISMALCGGIGIIH-HNCTPEYQANEVHKVK 103
           +T+   ++ PLV   M  V  AD+  + A  GG+GI+   + TPE   +E+ KV+
Sbjct: 5   ITEMFNIQYPLVCPGMTYVANADLVAATANAGGLGILAIGHLTPEQTLSEIRKVR 59


>UniRef50_A0TVV5 Cluster: 2-nitropropane dioxygenase, NPD; n=1;
           Burkholderia cenocepacia MC0-3|Rep: 2-nitropropane
           dioxygenase, NPD - Burkholderia cenocepacia MC0-3
          Length = 330

 Score = 41.9 bits (94), Expect = 0.039
 Identities = 72/294 (24%), Positives = 117/294 (39%), Gaps = 40/294 (13%)

Query: 184 LGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKARSYPNASKDSNKQLLVGAA 243
           LG  + DA Y+      G +  I   G   A   R +L+  R    A K     L +   
Sbjct: 25  LGPRVSDARYVAAVVNAGGMGFIVGAGFPDADEFRDELRTCRELSGA-KRFGVNLYISRQ 83

Query: 244 IGTRDTDRERLKLLVNNGVDVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVVTRMQ 303
            G  +  ++++++L+  GV   V   + G S   I          P ++  G  V+ ++ 
Sbjct: 84  AGGMERVKQQIRILIEEGV---VCVETAGASPEAI---------VPLLKEAGVKVLHKVP 131

Query: 304 AKNLIDAGVDALRVGMGSGSICITQEVMAC-GCPQATAVYQVASYARHFNVPVIADGGIQ 362
           A         A+R+G+  G I +  E     G  Q  ++ Q A   R  ++PV+  GGI 
Sbjct: 132 AVRYAHT---AMRMGV-DGVIVVGNECGGHPGIYQIGSIVQAAQAPREIDLPVVIGGGIG 187

Query: 363 SVGHIIKSLALGASTVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMESKDGKGS 422
           +   +   LA+G   V+MG+ +        E +    V+ K   G GS E++  K    S
Sbjct: 188 TGRQLAGVLAMGGDAVIMGTRML----VAEELWIHPDVKAKVVEGDGS-ESVVVK----S 238

Query: 423 AMSRYFHKESDKHRVAQGVSGSIV---DKGSVL---RFLPYLQAGMQHSCQDLG 470
           A+        D HRV +  S   V   D+  V    RF P++   + H     G
Sbjct: 239 AI-------RDHHRVLRNESAEAVLELDRAQVTEFERFRPHVMGALAHEAYVTG 285


>UniRef50_A0LL65 Cluster: Peptidase M50; n=2; Syntrophobacter
           fumaroxidans MPOB|Rep: Peptidase M50 - Syntrophobacter
           fumaroxidans (strain DSM 10017 / MPOB)
          Length = 383

 Score = 41.9 bits (94), Expect = 0.039
 Identities = 35/117 (29%), Positives = 60/117 (51%), Gaps = 7/117 (5%)

Query: 110 IRDPVCMGPENTVADVLEAKK-KNGFTGYPITQNGKLGGRLIGIVTSRDI-DFREGDPHL 167
           +R+ + + P+  V+ ++ A   + G+ GYP+ +     G  IGIV    I D  E D   
Sbjct: 261 VREVIGVPPDLPVSRLISAYLLRYGYKGYPVMERA---GEPIGIVEIFHIKDIHEEDRQS 317

Query: 168 -SLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKK 223
            ++ EVM PIN  +  +  + L DA   +  S  G+L +I  D ++V LI ++ L +
Sbjct: 318 RTVAEVMEPINPDLVVEPDLPLIDALKKIGDSDLGRLLVI-QDKQMVGLITKSGLNR 373


>UniRef50_Q8R7I7 Cluster: Putative N-acetylmannosamine-6-phosphate
           2-epimerase; n=8; Firmicutes|Rep: Putative
           N-acetylmannosamine-6-phosphate 2-epimerase -
           Thermoanaerobacter tengcongensis
          Length = 237

 Score = 41.9 bits (94), Expect = 0.039
 Identities = 33/141 (23%), Positives = 67/141 (47%), Gaps = 11/141 (7%)

Query: 252 ERLKLLVNNGVDVIVLDSSQGNSTYQI---KMIKYIKETYPEIQVVGGNVVTRMQAKNLI 308
           E +  ++  G D++ +D+++      +   + +K IKE YP+I V+  ++ T        
Sbjct: 85  EEVDKVIEAGADIVAIDATKAYKPGGLTTGEFLKRIKEKYPKILVMA-DIST-------Y 136

Query: 309 DAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQSVGHII 368
           + G++A ++G    S  ++         +      +   AR  NVP+IA+G I +    +
Sbjct: 137 EEGIEAEKLGFDLISTTLSGYTEYSPELEGPDYELIERLARKVNVPIIAEGRIWTPEEAV 196

Query: 369 KSLALGASTVMMGSLLAGTSE 389
           K+L  GA  V++G+ +    E
Sbjct: 197 KALEKGAYAVVVGTAITRPHE 217


>UniRef50_Q3ZXE7 Cluster: Metallopeptidase, M50 family; n=3;
           Dehalococcoides|Rep: Metallopeptidase, M50 family -
           Dehalococcoides sp. (strain CBDB1)
          Length = 379

 Score = 41.5 bits (93), Expect = 0.051
 Identities = 31/105 (29%), Positives = 54/105 (51%), Gaps = 4/105 (3%)

Query: 118 PENTVADVL-EAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLKEVMTPI 176
           P+NT+   L E          P+ +NGKL G LI +   + I   + +   S+++ MTP 
Sbjct: 259 PDNTLYQALHEYILPLNQRALPVFENGKLAG-LISLSDIKKIPTNQLN-QTSVRQAMTPF 316

Query: 177 NDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
             + T      L +   +L+     +LP+++ +G+L+ LI+RTDL
Sbjct: 317 EKLRTVGPEEHLGNVLNLLQSEDINQLPVLS-EGKLIGLISRTDL 360


>UniRef50_Q3DF47 Cluster: AcuB family protein; n=27;
           Streptococcus|Rep: AcuB family protein - Streptococcus
           agalactiae CJB111
          Length = 219

 Score = 41.5 bits (93), Expect = 0.051
 Identities = 41/204 (20%), Positives = 91/204 (44%), Gaps = 11/204 (5%)

Query: 114 VCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLI-GIVT------SRDIDFREGDPH 166
           V + P+ TVA+  +  +++     P+ +N +L G +  G +       +  +   E +  
Sbjct: 12  VYVSPDTTVAEAADLLREHHLRRLPVVENDQLVGLVTEGTMAEAQPSKATSLSIYEMNYL 71

Query: 167 LSLKEVMT-PINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKAR 225
           L+  ++    I D++T     +L+DA Y++   K G LP+++N G+L  ++   D+ KA 
Sbjct: 72  LNKTKIRDIMIKDIVTVSQYASLEDAIYLMMSRKIGVLPVVDN-GQLYGIVTDRDVFKAF 130

Query: 226 SYPNASKDSNKQLLVGA--AIGTRDTDRERLKLLVNNGVDVIVLDSSQGNSTYQIKMIKY 283
                      +L++ A   IG       RL     +   +++++   G    +I++  Y
Sbjct: 131 LEIAGYGQEGYRLVILADEGIGVLSKVLNRLSSANLSVKRLVIIERKAGKKAVEIQLEGY 190

Query: 284 IKETYPEIQVVGGNVVTRMQAKNL 307
             +   + ++V  +V+     K +
Sbjct: 191 ADKDVLKQELVFDDVIVETLEKTV 214


>UniRef50_Q24MB2 Cluster: Putative uncharacterized protein; n=2;
           Desulfitobacterium hafniense|Rep: Putative
           uncharacterized protein - Desulfitobacterium hafniense
           (strain Y51)
          Length = 214

 Score = 41.5 bits (93), Expect = 0.051
 Identities = 35/120 (29%), Positives = 58/120 (48%), Gaps = 21/120 (17%)

Query: 116 MGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPH----LSLKE 171
           + PE+ +AD +   ++      P+   GK    L+GIVT  D D RE  P     LS+ E
Sbjct: 20  VSPEDNIADTMALMREKQINRLPVVDKGK----LVGIVT--DGDLREVSPSPATTLSIFE 73

Query: 172 V-----MTPIND-----MITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
           +      T I D     +IT      ++DA  ++ +   G LP++ N G+LV ++  +D+
Sbjct: 74  LNYLVGKTSIRDVAVKKVITCTPDTKIEDAALLMREHGIGALPVVEN-GKLVGIVTESDI 132


>UniRef50_Q0PQV9 Cluster: Putative inosine-5'-monophosphate
           dehydrogenase; n=1; Endoriftia persephone
           'Hot96_1+Hot96_2'|Rep: Putative inosine-5'-monophosphate
           dehydrogenase - Endoriftia persephone 'Hot96_1+Hot96_2'
          Length = 137

 Score = 41.5 bits (93), Expect = 0.051
 Identities = 29/94 (30%), Positives = 45/94 (47%), Gaps = 9/94 (9%)

Query: 410 SLEAMESKDGKGSAMSRYFHKESDKHR-VAQGVSGSIVDKGSVLRFLPYLQAGMQHSCQD 468
           SL AM  K G      RYF + +DK + V +G+ G +  KGSV   +  L  G++ S   
Sbjct: 38  SLGAMSGKQGSSD---RYFQESTDKEKLVPEGIEGRVPYKGSVTNIIYQLVGGIRSSMGY 94

Query: 469 LGARSVSVLREMSHSGDLRFMKRTYSAQLEGNVH 502
            G  ++  +R        RF++ T +   E +VH
Sbjct: 95  TGCANLDEMRTKP-----RFVRVTGAGMTESHVH 123


>UniRef50_Q9YFL7 Cluster: Putative uncharacterized protein; n=1;
           Aeropyrum pernix|Rep: Putative uncharacterized protein -
           Aeropyrum pernix
          Length = 287

 Score = 41.5 bits (93), Expect = 0.051
 Identities = 36/129 (27%), Positives = 61/129 (47%), Gaps = 9/129 (6%)

Query: 111 RDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFRE--GDPHLS 168
           RD   + P++T+A   +    +  +  P+ +  KL G +I I    D   R+    P  S
Sbjct: 11  RDVYTVSPDDTLAHARKLMLTHDISRLPVVEGSKLRG-IITITDIADALVRKYPSRPANS 69

Query: 169 L--KEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKARS 226
           +  +EVM    D++T +   +++ A  ++ K   G +P++  DG L  +I RTDL   R 
Sbjct: 70  IYVREVMA--RDVVTIEGTKSVKTAASLMLKHNIGGVPVVAPDGTLEGIITRTDL--TRY 125

Query: 227 YPNASKDSN 235
           Y    K  N
Sbjct: 126 YSEKMKGVN 134


>UniRef50_Q8PYN6 Cluster: Conserved protein; n=6; Euryarchaeota|Rep:
           Conserved protein - Methanosarcina mazei (Methanosarcina
           frisia)
          Length = 283

 Score = 41.5 bits (93), Expect = 0.051
 Identities = 33/112 (29%), Positives = 57/112 (50%), Gaps = 9/112 (8%)

Query: 110 IRDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSL 169
           +RD  C     +  +VL+  K    +G P+ ++ K    ++GIVT  ++     +  L+L
Sbjct: 12  VRDVACATLPGSRDEVLKILKNKHISGVPVLKDSK----VVGIVTRTNLLQNPEEEQLAL 67

Query: 170 KEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
             +MT   D IT   G  LQ A  +L +    +LP++ +DG+LV L+   D+
Sbjct: 68  --LMT--RDPITISPGSDLQSAARLLLQHGIRRLPVV-DDGKLVGLVTVADV 114


>UniRef50_Q8PUG3 Cluster: Conserved protein; n=8; Euryarchaeota|Rep:
           Conserved protein - Methanosarcina mazei (Methanosarcina
           frisia)
          Length = 291

 Score = 41.5 bits (93), Expect = 0.051
 Identities = 30/121 (24%), Positives = 57/121 (47%), Gaps = 9/121 (7%)

Query: 103 KKYKHGFIRDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDI--DF 160
           K  KH     P+ +    ++ +      +N   G P+   GK    ++GI+T  DI    
Sbjct: 171 KHVKHYMKYPPLLVNLNASIQEATRLFIRNNVHGAPVEDKGK----IVGIITYTDIAHAI 226

Query: 161 REGDPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTD 220
            +G P++ +K++MT   ++IT    + L D   +  K   G+L I+  +G     +++TD
Sbjct: 227 AQGKPNVKVKDIMT--KELITVDGDMQLYDVVKLFHKYNVGRL-IVTINGVPKGTLSKTD 283

Query: 221 L 221
           +
Sbjct: 284 V 284


>UniRef50_O27616 Cluster: Inosine-5'-monophosphate dehydrogenase
           related protein X; n=1; Methanothermobacter
           thermautotrophicus str. Delta H|Rep:
           Inosine-5'-monophosphate dehydrogenase related protein X
           - Methanobacterium thermoautotrophicum
          Length = 133

 Score = 41.5 bits (93), Expect = 0.051
 Identities = 29/116 (25%), Positives = 58/116 (50%), Gaps = 8/116 (6%)

Query: 110 IRDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDP-HLS 168
           +RD +   P++ VA       +    G P+ +    G +L+G++T RDI    G+   L 
Sbjct: 20  LRDVIVSHPDDLVAAANLKMVRANVGGVPVVE----GDKLVGLITHRDILLAGGEALKLR 75

Query: 169 LKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKA 224
           +K++M+   D++       +   + I+  +   ++P++  DG LV LI ++ + KA
Sbjct: 76  VKDIMS--QDLVVIDEETPISRISRIMADTGYQRIPVV-RDGRLVGLITQSCIIKA 128


>UniRef50_P54606 Cluster: Uncharacterized protein yhcV; n=6;
           Bacillaceae|Rep: Uncharacterized protein yhcV - Bacillus
           subtilis
          Length = 140

 Score = 41.5 bits (93), Expect = 0.051
 Identities = 29/110 (26%), Positives = 57/110 (51%), Gaps = 11/110 (10%)

Query: 116 MGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFR---EG-DPHLSLKE 171
           + P  T+ +     K++     P+ + G L G L    T RDI  R   +G D    + E
Sbjct: 15  VSPNQTIQEAASLMKQHNVGAIPVVEQGVLKGML----TDRDIALRTTAQGRDGQTPVSE 70

Query: 172 VMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
           VM+   ++++    ++L+DA+ ++ + +  +LPI++ +  LV ++A  DL
Sbjct: 71  VMS--TELVSGNPNMSLEDASQLMAQHQIRRLPIVDQN-NLVGIVALGDL 117


>UniRef50_Q5LSF9 Cluster: Nucleotidyltransferase/CBS/cyclic
           nucleotide-binding domain protein; n=15;
           Alphaproteobacteria|Rep:
           Nucleotidyltransferase/CBS/cyclic nucleotide-binding
           domain protein - Silicibacter pomeroyi
          Length = 607

 Score = 41.1 bits (92), Expect = 0.068
 Identities = 33/137 (24%), Positives = 59/137 (43%), Gaps = 11/137 (8%)

Query: 111 RDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFR----EGDPH 166
           RDP    P+ TV    +  +    +   + ++    G L+GI+T RD+  +       P 
Sbjct: 150 RDPATCAPDTTVQAAAQEMRARSISSLCVCED----GALVGILTQRDLSGKVVAEARSPD 205

Query: 167 LSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKARS 226
             + +VMTP    +T        D  + + +   G +PI+   G LV ++ +TDL + ++
Sbjct: 206 TPVDQVMTPA--PLTLAPSAIGSDVLHAMMERHIGHIPIV-EAGRLVGMVTQTDLTRFQA 262

Query: 227 YPNASKDSNKQLLVGAA 243
             +A   S       AA
Sbjct: 263 VSSAELVSRLARATSAA 279


>UniRef50_Q8VKG1 Cluster: FMN-dependent alpha-hydroxy acid
           dehydrogenase family protein; n=27; Actinobacteria
           (class)|Rep: FMN-dependent alpha-hydroxy acid
           dehydrogenase family protein - Mycobacterium
           tuberculosis
          Length = 419

 Score = 41.1 bits (92), Expect = 0.068
 Identities = 27/78 (34%), Positives = 38/78 (48%), Gaps = 7/78 (8%)

Query: 304 AKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQS 363
           AK  +DAGV A+ V    G+          G P +       S A    V V+ DGGI+ 
Sbjct: 262 AKRAVDAGVSAISVSNHGGN-------NLDGTPASIRALPAVSAAVGDQVEVLLDGGIRR 314

Query: 364 VGHIIKSLALGASTVMMG 381
              ++K++ALGA  VM+G
Sbjct: 315 GSDVVKAVALGARAVMIG 332


>UniRef50_Q1AXH4 Cluster: CBS domain containing membrane protein;
           n=1; Rubrobacter xylanophilus DSM 9941|Rep: CBS domain
           containing membrane protein - Rubrobacter xylanophilus
           (strain DSM 9941 / NBRC 16129)
          Length = 232

 Score = 41.1 bits (92), Expect = 0.068
 Identities = 33/132 (25%), Positives = 67/132 (50%), Gaps = 21/132 (15%)

Query: 104 KYKHGFIRDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREG 163
           + +    R+ V + PE +VA+  E  +++     P+ +    GGRL+G+V+ RD+  R+ 
Sbjct: 15  RVRDSMTREVVTITPEASVAEAWELCRRHRIRHLPVVE----GGRLVGLVSDRDL--RDA 68

Query: 164 DPHLS------------LKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGE 211
            P  S            ++++M+   ++IT     T++ A   + + + G LP++  DG 
Sbjct: 69  SPPRSTGDEEHSFGWARMRDIMS--TELITIHPLDTIEHAAREIYERRIGCLPVV-EDGR 125

Query: 212 LVALIARTDLKK 223
           LV +I  +D+ +
Sbjct: 126 LVGIITSSDMMR 137


>UniRef50_A5UX62 Cluster: Polynucleotide adenylyltransferase region;
           n=2; Roseiflexus|Rep: Polynucleotide adenylyltransferase
           region - Roseiflexus sp. RS-1
          Length = 874

 Score = 41.1 bits (92), Expect = 0.068
 Identities = 23/61 (37%), Positives = 37/61 (60%), Gaps = 4/61 (6%)

Query: 165 PHLSLKEVMT-PINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKK 223
           P L+  ++MT P++   TA L  T+  A  +L +   G LP++N+DG +  LI+R DL +
Sbjct: 303 PALTAADIMTRPVH---TAPLDATVAQAEELLLRYGHGALPVVNHDGVVQGLISRRDLDR 359

Query: 224 A 224
           A
Sbjct: 360 A 360



 Score = 34.7 bits (76), Expect = 5.9
 Identities = 38/153 (24%), Positives = 70/153 (45%), Gaps = 9/153 (5%)

Query: 113 PVCMGP-ENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDID--FREGDPHLSL 169
           PV   P + TVA   E   + G    P+  +    G + G+++ RD+D   R G     L
Sbjct: 314 PVHTAPLDATVAQAEELLLRYGHGALPVVNHD---GVVQGLISRRDLDRALRHGLRDAPL 370

Query: 170 KEVMTPINDMITAQLGV-TLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKARSYP 228
              +     +++    + T++ A       + G+L ++++   L+ +I R+DL +A +  
Sbjct: 371 ARYLWHGPTLLSPDASLATVRSALAADNGDRTGRLLVVDSQKRLLGIITRSDLLRAWAAG 430

Query: 229 NASKDSNKQLLVGAAIGTRDTDRERLKLLVNNG 261
             +  S+   LVG A+  R  DR+ L +L   G
Sbjct: 431 QVAGTSDHD-LVGEAL-ERFLDRDLLAILRRAG 461


>UniRef50_A3W676 Cluster: Nucleotidyltransferase/CBS/cyclic
           nucleotide-binding domain protein; n=4;
           Rhodobacteraceae|Rep: Nucleotidyltransferase/CBS/cyclic
           nucleotide-binding domain protein - Roseovarius sp. 217
          Length = 612

 Score = 41.1 bits (92), Expect = 0.068
 Identities = 32/113 (28%), Positives = 54/113 (47%), Gaps = 11/113 (9%)

Query: 113 PVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDID---FREG-DPHLS 168
           P+   P+ T+ +V    + +  +   + +    G RL GI+T RD+      EG    + 
Sbjct: 157 PITCSPDATIKEVARLMRDHVISSVVVME----GARLAGIITVRDLSNKVLAEGLGGDIR 212

Query: 169 LKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
           + +VMTP  D +T + G    DA  +L   K   LP+    G ++ +I +TDL
Sbjct: 213 VAQVMTP--DPVTIEPGRLGLDALMLLSDLKINHLPVAQG-GRVLGMIGKTDL 262


>UniRef50_A0QGC0 Cluster: Oxidoreductase, 2-nitropropane dioxygenase
           family protein; n=5; Actinomycetales|Rep:
           Oxidoreductase, 2-nitropropane dioxygenase family
           protein - Mycobacterium avium (strain 104)
          Length = 293

 Score = 41.1 bits (92), Expect = 0.068
 Identities = 31/95 (32%), Positives = 46/95 (48%), Gaps = 9/95 (9%)

Query: 298 VVTRMQAKNLIDAGVDALRV-GMGSGSICITQEVMACGCPQATAVYQVASYARHFNVPVI 356
           V T   AK  +DAGVD L V G+  G           G   A+ +  +   A H +VP++
Sbjct: 95  VGTLAAAKKAVDAGVDGLVVEGVEGGGF-----KNRFG---ASTMVLLPLVAAHVDVPIV 146

Query: 357 ADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEAP 391
           A GGI     +  +  LGA  V MG+ L  ++++P
Sbjct: 147 AAGGICDARSMAAAFVLGAEAVQMGTRLLASADSP 181


>UniRef50_A0PYB8 Cluster: CBS domain containing protein; n=3;
           Clostridium|Rep: CBS domain containing protein -
           Clostridium novyi (strain NT)
          Length = 431

 Score = 41.1 bits (92), Expect = 0.068
 Identities = 29/115 (25%), Positives = 60/115 (52%), Gaps = 8/115 (6%)

Query: 110 IRDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSL 169
           I DP+ +  ++T+ +     +KN    YP+  N K    ++GI+T +D+  ++ D  L +
Sbjct: 195 ITDPIYVKFDDTIENFKNIIEKNKHQRYPVVDNNK---NVVGIITIKDLQ-KQNDNKL-V 249

Query: 170 KEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKA 224
           KE+M+   ++IT     T+  A +I+        P++    +L+ +++  D+ KA
Sbjct: 250 KEIMS--KELITVTEKTTVAYAAHIMGWEGIELCPVVQG-RQLIGVVSTEDILKA 301



 Score = 35.9 bits (79), Expect = 2.6
 Identities = 17/64 (26%), Positives = 35/64 (54%)

Query: 176 INDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKARSYPNASKDSN 235
           I D I  +   T+++   I+EK+K  + P+++N+  +V +I   DL+K        +  +
Sbjct: 195 ITDPIYVKFDDTIENFKNIIEKNKHQRYPVVDNNKNVVGIITIKDLQKQNDNKLVKEIMS 254

Query: 236 KQLL 239
           K+L+
Sbjct: 255 KELI 258


>UniRef50_A0G4J4 Cluster: 2-nitropropane dioxygenase, NPD; n=1;
           Burkholderia phymatum STM815|Rep: 2-nitropropane
           dioxygenase, NPD - Burkholderia phymatum STM815
          Length = 371

 Score = 41.1 bits (92), Expect = 0.068
 Identities = 19/38 (50%), Positives = 26/38 (68%)

Query: 353 VPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEA 390
           VPV+A GG+    HI+ +LALG   V +GSL  GT+E+
Sbjct: 218 VPVLAAGGVTRGSHILAALALGCQGVWVGSLWLGTAES 255


>UniRef50_O86223 Cluster: Putative uncharacterized protein HI0221.1;
           n=1; Haemophilus influenzae|Rep: Putative
           uncharacterized protein HI0221.1 - Haemophilus
           influenzae
          Length = 163

 Score = 41.1 bits (92), Expect = 0.068
 Identities = 32/82 (39%), Positives = 43/82 (52%), Gaps = 8/82 (9%)

Query: 399 GVRLKKYRGMGSLEAMESKDGKGSAMSRYFHKESDKHR-VAQGVSGSIVDKGSVLRFLPY 457
           G   K YRGMGSL AM     KGS+  RYF  ++   + V +G+ G I  KG  L+ + +
Sbjct: 55  GRAFKSYRGMGSLGAM----AKGSS-DRYFQSDNAADKLVPEGIEGRIPYKG-YLKEIIH 108

Query: 458 LQAGMQHSCQDL-GARSVSVLR 478
            Q G   SC  L G  ++  LR
Sbjct: 109 QQMGGLRSCMGLTGCATIDELR 130


>UniRef50_Q3ZYM9 Cluster:
           1-(5-phosphoribosyl)-5-[(5-
           phosphoribosylamino)methylideneamino]
           imidazole-4-carboxamide isomerase; n=4; Chloroflexi|Rep:
           1-(5-phosphoribosyl)-5-[(5-
           phosphoribosylamino)methylideneamino]
           imidazole-4-carboxamide isomerase - Dehalococcoides sp.
           (strain CBDB1)
          Length = 244

 Score = 41.1 bits (92), Expect = 0.068
 Identities = 37/159 (23%), Positives = 63/159 (39%), Gaps = 9/159 (5%)

Query: 232 KDSNKQLLVGAAIGTRDTDRERLKLLVNNGVDVIVLDSSQGNSTYQIKMI--KYIKETYP 289
           K+     L+   +G      E +K L+  GVD ++L ++   +   +K I  +Y      
Sbjct: 74  KEIANSALIPVEVGGGIRSMETVKKLLVAGVDRVILGTAAVENPELVKEICARYADSVAV 133

Query: 290 EIQVVGGNVVTRMQAKNLIDAGVDALRVGMGSGSICITQ----EVMACGCPQATAVYQVA 345
            I    G V TR    N     +DAL +      + I +    ++   G         + 
Sbjct: 134 SIDARNGKVATRGWVTN---TEIDALELARSMKKLGIRRFIYTDISRDGTLSEPNFAAIR 190

Query: 346 SYARHFNVPVIADGGIQSVGHIIKSLALGASTVMMGSLL 384
                 NVPVIA GG+ S+ H+     +GA   ++G  +
Sbjct: 191 DLISAINVPVIASGGVSSLSHLRLLKDIGAEGAIVGKAI 229


>UniRef50_Q98QF8 Cluster: MG2+ TRANSPORT PROTEIN; n=1; Mycoplasma
           pulmonis|Rep: MG2+ TRANSPORT PROTEIN - Mycoplasma
           pulmonis
          Length = 485

 Score = 40.7 bits (91), Expect = 0.090
 Identities = 23/74 (31%), Positives = 38/74 (51%), Gaps = 5/74 (6%)

Query: 148 RLIGIVTSRDIDFREGDPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIIN 207
           +L+G V   DI F   DP+  +K VM  +N ++T     TL+ A  I  K     LP+IN
Sbjct: 173 KLLGSVALEDIIFE--DPYEKIKNVMFSVNSILTTD---TLEHAALIFSKEGMSVLPVIN 227

Query: 208 NDGELVALIARTDL 221
            +  L+ ++   ++
Sbjct: 228 QNKYLIGMVTTDEI 241


>UniRef50_Q74HC1 Cluster: Glycolate oxidase; n=8;
           Lactobacillaceae|Rep: Glycolate oxidase - Lactobacillus
           johnsonii
          Length = 412

 Score = 40.7 bits (91), Expect = 0.090
 Identities = 36/104 (34%), Positives = 50/104 (48%), Gaps = 11/104 (10%)

Query: 281 IKYIKETYPEIQVVGGNVVTRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATA 340
           I+ IKE   ++ V+   V     A   I AG D + V    G     +EV   G P    
Sbjct: 227 IRKIKEI-ADVPVIVKGVECAEDAMLAIGAGADGIVVSNHGG-----REVD--GAPATID 278

Query: 341 VY-QVASYARHFN--VPVIADGGIQSVGHIIKSLALGASTVMMG 381
           V  ++A   R  N  VP+I DGG++   H+ K+LALGA  V +G
Sbjct: 279 VLPEIAKAVRSSNHRVPIILDGGVRRGSHVFKALALGADLVGIG 322


>UniRef50_Q9LUF7 Cluster: Emb|CAB86899.1; n=6; Magnoliophyta|Rep:
           Emb|CAB86899.1 - Arabidopsis thaliana (Mouse-ear cress)
          Length = 548

 Score = 40.7 bits (91), Expect = 0.090
 Identities = 24/74 (32%), Positives = 45/74 (60%), Gaps = 7/74 (9%)

Query: 148 RLIGIVTSRDIDFREGDPHL-----SLKEVMTPINDMITAQLGVTLQDANYILEKSKKGK 202
           +L+GI+TS+DI  R    +L     ++++VMTP  +  T  + +   +A +I+   K   
Sbjct: 271 KLVGILTSKDILMRVISQNLPQETTTVEKVMTPNPESATVDMAIV--EALHIMHNGKFLH 328

Query: 203 LPIINNDGELVALI 216
           LP+++ DG++VA+I
Sbjct: 329 LPVLDKDGDVVAVI 342


>UniRef50_Q3IUS4 Cluster: Probable metalloprotease/ CBS domain
           protein; n=1; Natronomonas pharaonis DSM 2160|Rep:
           Probable metalloprotease/ CBS domain protein -
           Natronomonas pharaonis (strain DSM 2160 / ATCC 35678)
          Length = 396

 Score = 40.7 bits (91), Expect = 0.090
 Identities = 28/104 (26%), Positives = 45/104 (43%), Gaps = 4/104 (3%)

Query: 121 TVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLKEVMTPINDMI 180
           T+  +L+   +   TGYP+ +    GG+L+GIVT  DI     +     +       D+ 
Sbjct: 279 TLDAILDRMFEERHTGYPVVE----GGKLVGIVTLADIRNVHPEKRSETRVADVMSEDLE 334

Query: 181 TAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKA 224
                    DA   L +   G+L + +  G L  L+ R+DL  A
Sbjct: 335 AVSPDTEAMDAMRQLAQHSVGRLVVTDEFGNLAGLLTRSDLVTA 378


>UniRef50_A2BJY0 Cluster: Voltage-gated chloride channel protein;
           n=1; Hyperthermus butylicus DSM 5456|Rep: Voltage-gated
           chloride channel protein - Hyperthermus butylicus
           (strain DSM 5456 / JCM 9403)
          Length = 563

 Score = 40.7 bits (91), Expect = 0.090
 Identities = 30/118 (25%), Positives = 61/118 (51%), Gaps = 10/118 (8%)

Query: 111 RDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDI-DFREGD-PHLS 168
           R  V + P++ +  V+E   +   TG+P+     + GR++G++T  D+  +R  +   + 
Sbjct: 444 RSVVVVRPDDPLKRVIELTAETHHTGFPVV----VDGRVVGMITLSDVLRYRHSELGKVK 499

Query: 169 LKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINN--DGELVALIARTDLKKA 224
           +KE MT    +I      +L DA   + +   G+LP++ N    +L+ +I + D+ +A
Sbjct: 500 VKEAMT--RSVIAVLPDDSLADALRKMLRYGIGRLPVVENYESMKLIGIITKKDIVRA 555


>UniRef50_Q58069 Cluster: Uncharacterized protein MJ0653; n=1;
           Methanocaldococcus jannaschii|Rep: Uncharacterized
           protein MJ0653 - Methanococcus jannaschii
          Length = 194

 Score = 40.7 bits (91), Expect = 0.090
 Identities = 32/113 (28%), Positives = 54/113 (47%), Gaps = 9/113 (7%)

Query: 113 PVCMGPEN-TVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLKE 171
           PV    +N ++ D+     +N      I +N K     IGIVT RDI  R    +L  K+
Sbjct: 16  PVIKATKNMSIYDIANIMTENNIGAVVIVENNKP----IGIVTERDIVKRVVSKNLKPKD 71

Query: 172 VMTP---INDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
           V+        +IT     ++ +A  I+      +LP++  DGELV ++ ++D+
Sbjct: 72  VLAEEVMSKKIITIPQNASITEAAKIMATHGIKRLPVV-KDGELVGIVTQSDI 123


>UniRef50_Q9RVN7 Cluster: Acetoin utilization protein, putative;
           n=4; Deinococci|Rep: Acetoin utilization protein,
           putative - Deinococcus radiodurans
          Length = 209

 Score = 40.3 bits (90), Expect = 0.12
 Identities = 40/186 (21%), Positives = 84/186 (45%), Gaps = 22/186 (11%)

Query: 111 RDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDI------------ 158
           R PV + P+  V D L+   +      P+ ++GK    L+GI T +D+            
Sbjct: 9   RTPVTVTPDTPVMDALKLISERRVRRLPVLRDGK----LVGITTRKDLKDAMPSKATTLS 64

Query: 159 --DFREGDPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALI 216
             +       L+++E+M     +ITAQ    ++DA   +++ K G LP++N  G++  +I
Sbjct: 65  VWELNYLLSKLTVEEIMG--RPVITAQEDEYMEDAALRMQEHKFGGLPVLNAQGQMSDII 122

Query: 217 ARTDLKKARSYPNASKDSNKQLLVGAAIGTRDTDRERLKLLVNNGVDVIV--LDSSQGNS 274
             +D+ +A +      +  ++L +         +R    +  +N + V    +D + GN 
Sbjct: 123 TTSDVIRAFTTILGMNEGGQRLTLDMPDVPGSLERAAQAVQPSNIISVATYDVDGAGGNR 182

Query: 275 TYQIKM 280
            + +++
Sbjct: 183 RFVLRV 188


>UniRef50_A4AAP3 Cluster: Acetoin utilization protein AcuB; n=1;
           Congregibacter litoralis KT71|Rep: Acetoin utilization
           protein AcuB - Congregibacter litoralis KT71
          Length = 147

 Score = 40.3 bits (90), Expect = 0.12
 Identities = 32/119 (26%), Positives = 57/119 (47%), Gaps = 15/119 (12%)

Query: 113 PVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDI----DFR--EGDPH 166
           P  +GP++++ D     +++     PI  N    G +IG+V+ RD+    D R    D  
Sbjct: 12  PYTLGPDDSLLDAASLMREHHIRHVPIVAN---DGNVIGVVSHRDVLAASDSRLVHQDLQ 68

Query: 167 LSLKEVMTPINDMITAQLGVTLQDANY-----ILEKSKKGKLPIINNDGELVALIARTD 220
            S KE    ++ ++T+ +    +DA        L K + G +P +  DG LV +I+ +D
Sbjct: 69  SSAKENYVALSAVMTSPVQTVTEDAELRAVAGYLRKQRLGCMP-VTRDGALVGIISDSD 126


>UniRef50_A3SFF5 Cluster: FMN-dependent alpha-hydroxy acid
           dehydrogenase; n=2; Sulfitobacter|Rep: FMN-dependent
           alpha-hydroxy acid dehydrogenase - Sulfitobacter sp.
           EE-36
          Length = 375

 Score = 40.3 bits (90), Expect = 0.12
 Identities = 27/78 (34%), Positives = 38/78 (48%), Gaps = 7/78 (8%)

Query: 304 AKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQS 363
           A+  +DAGV  + V    G +  T   +     Q  AV Q        +VPV  DGGI+ 
Sbjct: 246 ARRFVDAGVAGIIVSNHGGRVLDT---VPAPVTQLAAVVQAVGQ----DVPVYLDGGIRR 298

Query: 364 VGHIIKSLALGASTVMMG 381
              + K+LALGA  V++G
Sbjct: 299 GSDVFKALALGAEAVLVG 316


>UniRef50_Q3SB86 Cluster: CBS domain protein; n=1; uncultured
           euryarchaeote Alv-FOS5|Rep: CBS domain protein -
           uncultured euryarchaeote Alv-FOS5
          Length = 156

 Score = 40.3 bits (90), Expect = 0.12
 Identities = 29/95 (30%), Positives = 42/95 (44%), Gaps = 5/95 (5%)

Query: 111 RDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLK 170
           +D V +     +A V++  KK   +G P+  N    G+LIG+VT  DI      P     
Sbjct: 10  KDVVYVHDNEGIAKVIDIMKKRKISGLPVVNNS---GKLIGVVTDGDIIRSLDIPDFPTS 66

Query: 171 EVMTPINDMITAQLGVTLQ--DANYILEKSKKGKL 203
            V  P  D I   + V ++  D    LE  K GK+
Sbjct: 67  AVSPPPFDFIERLIKVKMEEWDVERALEMWKSGKV 101



 Score = 34.3 bits (75), Expect = 7.8
 Identities = 17/56 (30%), Positives = 33/56 (58%), Gaps = 2/56 (3%)

Query: 169 LKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKA 224
           + +VMT   D  +  +   ++ A  I+ +    +LP++++DG+LV ++ R DL KA
Sbjct: 101 VSDVMT--KDPASVHMNDDVEKAADIMLEKNVHRLPVVDDDGKLVGIVTRLDLLKA 154


>UniRef50_A7IAI3 Cluster: Putative signal transduction protein with
           CBS domains; n=1; Candidatus Methanoregula boonei
           6A8|Rep: Putative signal transduction protein with CBS
           domains - Methanoregula boonei (strain 6A8)
          Length = 249

 Score = 40.3 bits (90), Expect = 0.12
 Identities = 29/110 (26%), Positives = 56/110 (50%), Gaps = 12/110 (10%)

Query: 118 PENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLKEVMTP-- 175
           P +T+  V     + GFT +P+ +      RL+G+++ RD+  R G    ++ +  T   
Sbjct: 141 PADTLQQVYAKITECGFTAFPVVKKR----RLVGLISRRDL-IRSGGVRSAIAQNSTRTV 195

Query: 176 ----INDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
               I D+IT   G  L +A  ++  +   +LP+++N+  +V +I R D+
Sbjct: 196 GDVMIPDVITVPSGSLLSEAARLMVDNDISRLPVVDNE-SVVGIIDRHDV 244


>UniRef50_Q15XE0 Cluster: 2-nitropropane dioxygenase, NPD; n=9;
           Proteobacteria|Rep: 2-nitropropane dioxygenase, NPD -
           Pseudoalteromonas atlantica (strain T6c / BAA-1087)
          Length = 319

 Score = 39.9 bits (89), Expect = 0.16
 Identities = 25/88 (28%), Positives = 42/88 (47%), Gaps = 7/88 (7%)

Query: 304 AKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQS 363
           A   ++AGVD L V  G G      +         +++  +       NVP++A GGI  
Sbjct: 128 ALKAVEAGVDGLIVEGGEGGGFKNAD-------DVSSMVLIPQVCEAVNVPIVAAGGIMD 180

Query: 364 VGHIIKSLALGASTVMMGSLLAGTSEAP 391
              +  ++ALGA  V+MG+ +   +E+P
Sbjct: 181 GRSMAAAMALGAEGVLMGTRILSATESP 208


>UniRef50_A6GD90 Cluster: Acetoin utilization protein AcuB; n=1;
           Plesiocystis pacifica SIR-1|Rep: Acetoin utilization
           protein AcuB - Plesiocystis pacifica SIR-1
          Length = 141

 Score = 39.9 bits (89), Expect = 0.16
 Identities = 23/59 (38%), Positives = 37/59 (62%), Gaps = 3/59 (5%)

Query: 167 LSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKAR 225
           +SL  VMT   D+ITA    T+++A  +LE S    LP++ NDG L+ +++  DL++ R
Sbjct: 1   MSLDAVMT--TDLITAPPTATVREALRLLEDSDIRHLPVV-NDGHLIGIVSDRDLREYR 56


>UniRef50_A6CN21 Cluster: CBS domain protein; n=1; Bacillus sp.
           SG-1|Rep: CBS domain protein - Bacillus sp. SG-1
          Length = 144

 Score = 39.9 bits (89), Expect = 0.16
 Identities = 29/106 (27%), Positives = 57/106 (53%), Gaps = 11/106 (10%)

Query: 120 NTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFR---EGDPHLS-LKEVMTP 175
           + V +V    K+N   G PI      G  L+G++T RDI  R   E  P  S ++EVM+ 
Sbjct: 18  DNVYEVAVKMKENDVGGIPIVD----GDHLVGMITDRDIVVRGVAEKHPGSSKVEEVMS- 72

Query: 176 INDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
            ++++T     T+ +A  ++ + +  +LP+++   +L+ +++  DL
Sbjct: 73  -DELVTVGADTTIDEAASLMSRHQIRRLPVVDGQ-KLIGIVSLGDL 116


>UniRef50_Q01N18 Cluster: OSIGBa0147B06.5 protein; n=3; Oryza
           sativa|Rep: OSIGBa0147B06.5 protein - Oryza sativa
           (Rice)
          Length = 224

 Score = 39.9 bits (89), Expect = 0.16
 Identities = 22/78 (28%), Positives = 43/78 (55%), Gaps = 2/78 (2%)

Query: 147 GRLIGIVTSRDIDFREGDPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPII 206
           GR IG+V+ +D          ++ EVM+  +  IT     T+ +A  ++ K K  ++P++
Sbjct: 143 GRCIGVVSKKDKAKASNGLDSTVGEVMS--SPAITLTPEKTVLEAAALMLKEKVHRIPVV 200

Query: 207 NNDGELVALIARTDLKKA 224
           N   +++ ++ RTD+ KA
Sbjct: 201 NEQQQVIGIVTRTDVFKA 218


>UniRef50_A7DSJ1 Cluster: Putative signal-transduction protein with
           CBS domains; n=1; Candidatus Nitrosopumilus maritimus
           SCM1|Rep: Putative signal-transduction protein with CBS
           domains - Candidatus Nitrosopumilus maritimus SCM1
          Length = 165

 Score = 39.9 bits (89), Expect = 0.16
 Identities = 29/87 (33%), Positives = 47/87 (54%), Gaps = 7/87 (8%)

Query: 150 IGIVTSRD----IDFREGDPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPI 205
           +GIVT RD    I      PH  + EVM+  + +IT +   T+ +A  I+++    KLP+
Sbjct: 67  LGIVTERDFVTKIVAERKTPHTKIFEVMS--SPLITIKSESTIWEAAEIMKEKSIHKLPV 124

Query: 206 INNDGELVALIARTDLKKARSYPNASK 232
           I  D E+V +I  TD+ +  S  + S+
Sbjct: 125 I-EDEEIVGIITTTDIVRISSVGSDSQ 150


>UniRef50_Q9CG58 Cluster: L-lactate oxidase; n=6; Bacteria|Rep:
           L-lactate oxidase - Lactococcus lactis subsp. lactis
           (Streptococcus lactis)
          Length = 383

 Score = 39.5 bits (88), Expect = 0.21
 Identities = 32/121 (26%), Positives = 54/121 (44%), Gaps = 11/121 (9%)

Query: 261 GVDVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVVTRMQAKNLIDAGVDALRVGMG 320
           G+  I   + QG     I+ IK I      + V+   V + + A + I+AG D + V   
Sbjct: 226 GISEIYAAAKQGLVLEDIQKIKKITN----LPVIVKGVQSPIDADDAINAGADGIWVSNH 281

Query: 321 SGSICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQSVGHIIKSLALGASTVMM 380
            G           G P +  V  + + + +  VP++ D G++   H+ K+LA GA  V +
Sbjct: 282 GGR-------QLDGGPASIDVLPLIAKSVNHRVPIVFDSGVRRGEHVFKALAQGADVVAV 334

Query: 381 G 381
           G
Sbjct: 335 G 335


>UniRef50_Q62DY2 Cluster: FMN-dependent dehydrogenase; n=17;
           Proteobacteria|Rep: FMN-dependent dehydrogenase -
           Burkholderia mallei (Pseudomonas mallei)
          Length = 412

 Score = 39.5 bits (88), Expect = 0.21
 Identities = 34/134 (25%), Positives = 57/134 (42%), Gaps = 8/134 (5%)

Query: 281 IKYIKETYPEIQVVGGNVVTRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATA 340
           +K+++  +P   V+ G ++    A+  +D GVD + +    G             P    
Sbjct: 243 VKWLRARWPGRIVIKG-ILDPDDARRAVDEGVDGILISNHGGR-------QLDPAPSVMD 294

Query: 341 VYQVASYARHFNVPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEAPGEYFFSDGV 400
           V    + A      ++ DGG++    +IK+LALGAS V +G        A GE   S  +
Sbjct: 295 VLPEIAEAVGKRTEILMDGGVRRGADVIKALALGASAVSIGRAYVYGLGAAGEKGVSRCL 354

Query: 401 RLKKYRGMGSLEAM 414
            L K   + +L  M
Sbjct: 355 ELLKGEMLPALNMM 368


>UniRef50_Q2CIM8 Cluster: Alcohol dehydrogenase, zinc containing;
           n=2; Rhodobacterales|Rep: Alcohol dehydrogenase, zinc
           containing - Oceanicola granulosus HTCC2516
          Length = 329

 Score = 39.5 bits (88), Expect = 0.21
 Identities = 39/156 (25%), Positives = 63/156 (40%), Gaps = 8/156 (5%)

Query: 295 GGNVVTRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFNVP 354
           GG    +  ++ +   G   + + + + ++     +M  G P+   ++      RH  V 
Sbjct: 17  GGPEALKPVSRTMPAPGPKDVLIRVRASAVSRADGMMRAGTPRFARLFLGLRRPRHDLVG 76

Query: 355 VIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAM 414
               G + SVGH + + A G     M  L  G + A       DGV L K   M   EA 
Sbjct: 77  TCFSGEVVSVGHAVSNFAAGDPVYGMSGLNFG-ANASHICMDEDGVLLHKPAAMSHEEAA 135

Query: 415 ESKDGKGSAMSRYFHKESDKHRVAQ-----GVSGSI 445
              DG  ++++  F KE  + R  Q     G SGS+
Sbjct: 136 VMSDGAVTSLN--FLKEIGELRAGQRILILGASGSL 169


>UniRef50_Q1AXT4 Cluster: Inorganic diphosphatase; n=1; Rubrobacter
           xylanophilus DSM 9941|Rep: Inorganic diphosphatase -
           Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
          Length = 540

 Score = 39.5 bits (88), Expect = 0.21
 Identities = 23/80 (28%), Positives = 41/80 (51%), Gaps = 4/80 (5%)

Query: 167 LSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKARS 226
           L +K+VM    +++TA     L      + K+  G++PI+++DG L  +I   DL  AR 
Sbjct: 68  LRVKDVMN--KNLVTANRNDPLHSVGLAMAKNNIGQIPIVDDDGTLAGIITERDL--ARM 123

Query: 227 YPNASKDSNKQLLVGAAIGT 246
           Y   S+D +       ++G+
Sbjct: 124 YIRESRDPSTFAHTPVSVGS 143


>UniRef50_A5URS2 Cluster: CBS domain containing protein; n=2;
           Roseiflexus|Rep: CBS domain containing protein -
           Roseiflexus sp. RS-1
          Length = 225

 Score = 39.5 bits (88), Expect = 0.21
 Identities = 29/117 (24%), Positives = 58/117 (49%), Gaps = 11/117 (9%)

Query: 114 VCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLI--GIVTSRDID-------FREGD 164
           + + P  T+A+     ++      PI +NGKL G +    + +++ +D       +R   
Sbjct: 15  IVIAPTATLAEAQRLMEQRRIRRLPIVENGKLAGIITRGDLRSAQPVDTTLSYYEWRALL 74

Query: 165 PHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
             +++ E MT    +IT     +  DA  ++ K K G LP+++++G +V +I  +DL
Sbjct: 75  DRVTVAECMT--RHVITITPDASTLDAARLMLKHKIGGLPVVDDEGRVVGIITESDL 129


>UniRef50_Q4PDX7 Cluster: Putative uncharacterized protein; n=1;
           Ustilago maydis|Rep: Putative uncharacterized protein -
           Ustilago maydis (Smut fungus)
          Length = 708

 Score = 39.5 bits (88), Expect = 0.21
 Identities = 33/101 (32%), Positives = 51/101 (50%), Gaps = 8/101 (7%)

Query: 121 TVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFR---EG-DPHL-SLKEVMTP 175
           T   V+E+      TG  I   G + G++ GI TS+D+  R    G DP   S+  VMTP
Sbjct: 265 TAVCVMESTGSGPGTGQ-IGGGGAVSGKIAGIFTSKDVVLRVIAAGLDPKTCSVVRVMTP 323

Query: 176 INDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALI 216
             D  TA   +T+Q+A   +   +   LP+++ D  LV ++
Sbjct: 324 HPD--TAPPSLTIQEALRKMHDGRYLNLPVVDVDSRLVGVV 362


>UniRef50_Q8TZ50 Cluster: CBS-domain-containing protein; n=1;
           Methanopyrus kandleri|Rep: CBS-domain-containing protein
           - Methanopyrus kandleri
          Length = 393

 Score = 39.5 bits (88), Expect = 0.21
 Identities = 30/114 (26%), Positives = 55/114 (48%), Gaps = 12/114 (10%)

Query: 113 PVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDI-DF-REGDP--HLS 168
           P  + P+  + + +     +G    P+ ++G+     +G+VT  DI D  RE D    + 
Sbjct: 79  PETVTPDTLIVEAITEMIDSGLRALPVVEDGEF----VGLVTEYDIIDVARESDELTKID 134

Query: 169 LKEVM-TPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
            +EVM TP+   IT     T+  A  I+      +LP++N+  +L  ++  TD+
Sbjct: 135 AREVMSTPV---ITIHENDTIAKARAIMRDHGISRLPVVNDANKLRGIVTTTDI 185



 Score = 35.5 bits (78), Expect = 3.4
 Identities = 19/56 (33%), Positives = 35/56 (62%), Gaps = 1/56 (1%)

Query: 169 LKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKA 224
           ++E+MTP  ++ITA+ G  L      LE+    ++PI+ +DG++V +I+  D+  A
Sbjct: 8   VEEIMTPAEEVITAEPGEPLSKIFSKLERHGVKEIPIV-DDGKVVGMISYYDVVDA 62


>UniRef50_O13965 Cluster: Meiotically up-regulated gene 70 protein;
           n=2; Schizosaccharomyces pombe|Rep: Meiotically
           up-regulated gene 70 protein - Schizosaccharomyces pombe
           (Fission yeast)
          Length = 730

 Score = 39.5 bits (88), Expect = 0.21
 Identities = 38/160 (23%), Positives = 71/160 (44%), Gaps = 12/160 (7%)

Query: 112 DPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFR---EG-DPH- 166
           +P  +G   TVA+  E+  ++G +   +  NG +     G+ T+ D+  R    G DP+ 
Sbjct: 266 EPFLVGTRTTVAEATESMARSGVSAVLVMDNGAVS----GVFTAHDVVLRVLAAGLDPYR 321

Query: 167 LSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKA-R 225
            S+  VMTP  D   A L V+      I  + K   LP+++    ++ +++   L  A  
Sbjct: 322 SSVIRVMTPHPDCALASLRVSTALERMI--EGKFSNLPVVDESDAIIGMLSLFHLATAIE 379

Query: 226 SYPNASKDSNKQLLVGAAIGTRDTDRERLKLLVNNGVDVI 265
             P   ++   Q    A I   +   ++ + L+ N  +V+
Sbjct: 380 QTPEEEEEVFDQAENDAGIEPSNGFEDQQQQLLGNSNEVV 419


>UniRef50_Q7U851 Cluster:
           1-(5-phosphoribosyl)-5-[(5-
           phosphoribosylamino)methylideneamino]
           imidazole-4-carboxamide isomerase; n=39; Bacteria|Rep:
           1-(5-phosphoribosyl)-5-[(5-
           phosphoribosylamino)methylideneamino]
           imidazole-4-carboxamide isomerase - Synechococcus sp.
           (strain WH8102)
          Length = 255

 Score = 39.5 bits (88), Expect = 0.21
 Identities = 40/142 (28%), Positives = 64/142 (45%), Gaps = 12/142 (8%)

Query: 252 ERLKLLVNNGVDVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVG-----GNVVTRMQAKN 306
           ER + L+  G+D ++L +    +  Q  +++ + E YP   VVG     G V TR   + 
Sbjct: 87  ERAEQLLACGLDRVILGTV---AIEQPDLVRSLAERYPGRIVVGIDAKDGRVATRGWIEQ 143

Query: 307 LIDAGVDALRVGMGSG-SICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQSVG 365
                 D  R    SG +  IT ++   G      +  + + A   +VPVIA GGI  + 
Sbjct: 144 SDVLATDLARTFSSSGIAAIITTDIATDGTLAGPNLEALRTMAASSSVPVIASGGIGCMA 203

Query: 366 HIIKSL---ALGASTVMMGSLL 384
            ++  L    LG S V++G  L
Sbjct: 204 DLLSLLPLEPLGVSGVIVGRAL 225


>UniRef50_Q4US80 Cluster: 2-nitropropane dioxygenase; n=9;
           Proteobacteria|Rep: 2-nitropropane dioxygenase -
           Xanthomonas campestris pv. campestris (strain 8004)
          Length = 364

 Score = 39.1 bits (87), Expect = 0.27
 Identities = 22/47 (46%), Positives = 27/47 (57%), Gaps = 2/47 (4%)

Query: 350 HFNVPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEA--PGEY 394
           H  +PVIA GGI     I  +L LGAS V +G+ L  T EA  PG +
Sbjct: 217 HLEIPVIAAGGIADARGIAAALTLGASAVQIGTGLLRTPEAALPGAW 263


>UniRef50_Q180W2 Cluster: Putative uncharacterized protein; n=1;
           Clostridium difficile 630|Rep: Putative uncharacterized
           protein - Clostridium difficile (strain 630)
          Length = 153

 Score = 39.1 bits (87), Expect = 0.27
 Identities = 20/61 (32%), Positives = 35/61 (57%), Gaps = 2/61 (3%)

Query: 170 KEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKARSYPN 229
           KE+MT   D+I A+   ++ D   +L   K G LP+++++  +V +I+ TD+ K   Y  
Sbjct: 7   KEIMT--TDVIVAKQDDSIADVANMLIAEKIGGLPVVDSENRVVGIISETDILKKEKYIE 64

Query: 230 A 230
           A
Sbjct: 65  A 65


>UniRef50_A6QB31 Cluster: 2-nitropropane dioxygenase; n=29;
           Bacteria|Rep: 2-nitropropane dioxygenase - Sulfurovum
           sp. (strain NBC37-1)
          Length = 369

 Score = 39.1 bits (87), Expect = 0.27
 Identities = 18/38 (47%), Positives = 24/38 (63%)

Query: 352 NVPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSE 389
           ++PVIA GG+     I+K + LGAS V MG+   GT E
Sbjct: 215 DIPVIAAGGVWDRADIVKMMELGASAVQMGTRFIGTVE 252


>UniRef50_A3PVW7 Cluster: 2-nitropropane dioxygenase, NPD; n=8;
           Corynebacterineae|Rep: 2-nitropropane dioxygenase, NPD -
           Mycobacterium sp. (strain JLS)
          Length = 295

 Score = 39.1 bits (87), Expect = 0.27
 Identities = 31/93 (33%), Positives = 43/93 (46%), Gaps = 8/93 (8%)

Query: 298 VVTRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFNVPVIA 357
           V T   A+  +DAG+D L V  G+       E    G P+   +  +      F+VPV+A
Sbjct: 120 VGTAAAARRAVDAGIDVL-VARGA-------EGGGHGEPRVGTLALLTDLLERFDVPVLA 171

Query: 358 DGGIQSVGHIIKSLALGASTVMMGSLLAGTSEA 390
            GGI S   +   LA GAS   +G+  A   EA
Sbjct: 172 AGGIASGRGLAAVLAAGASAAWIGTGFAACPEA 204


>UniRef50_A1ZUR2 Cluster: CBS domain protein; n=2;
           Bacteroidetes|Rep: CBS domain protein - Microscilla
           marina ATCC 23134
          Length = 140

 Score = 39.1 bits (87), Expect = 0.27
 Identities = 22/57 (38%), Positives = 37/57 (64%), Gaps = 3/57 (5%)

Query: 167 LSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKK 223
           L++++VM  I+ ++T     T+++A  IL K +   LP+I+N+G LV +I  TDL K
Sbjct: 80  LTIEQVM--IDQLVTVNTETTIREAAEILSKKEFHALPVIDNNG-LVGIITTTDLIK 133


>UniRef50_Q54H97 Cluster: Putative acetoin dehydrogenase; n=1;
           Dictyostelium discoideum AX4|Rep: Putative acetoin
           dehydrogenase - Dictyostelium discoideum AX4
          Length = 145

 Score = 39.1 bits (87), Expect = 0.27
 Identities = 32/115 (27%), Positives = 54/115 (46%), Gaps = 16/115 (13%)

Query: 120 NTVADV-LEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLS------LKEV 172
           +T  DV L++   N     P+  N    G L GI+T RD+      P L       L+++
Sbjct: 19  DTTLDVALKSLNANSIHRLPVVDND---GNLKGIITDRDLRLATDSPFLPENNEDRLEKL 75

Query: 173 MTPINDMITAQLGVTLQDANYILEKSKK------GKLPIINNDGELVALIARTDL 221
                  I  Q  VT++D + ++E +K       G LP+++  G L+ ++ R+DL
Sbjct: 76  RLHKVSSIMKQNPVTIEDFSPVVEAAKLMRVTNVGGLPVLDKKGRLIGMVTRSDL 130



 Score = 34.7 bits (76), Expect = 5.9
 Identities = 20/70 (28%), Positives = 36/70 (51%), Gaps = 2/70 (2%)

Query: 169 LKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKARSYP 228
           +K++M+    + T  L  TL  A   L  +   +LP+++NDG L  +I   DL+ A   P
Sbjct: 5   VKQLMS--KSLFTINLDTTLDVALKSLNANSIHRLPVVDNDGNLKGIITDRDLRLATDSP 62

Query: 229 NASKDSNKQL 238
              +++  +L
Sbjct: 63  FLPENNEDRL 72


>UniRef50_Q2RGX5 Cluster: Ferredoxin-dependent glutamate synthase;
           n=1; Moorella thermoacetica ATCC 39073|Rep:
           Ferredoxin-dependent glutamate synthase - Moorella
           thermoacetica (strain ATCC 39073)
          Length = 472

 Score = 38.7 bits (86), Expect = 0.36
 Identities = 30/85 (35%), Positives = 47/85 (55%), Gaps = 10/85 (11%)

Query: 307 LIDAGVDALRV-GMGS---GSICITQEVMACGCPQATAVYQVASYARHFNVP----VIAD 358
           L++AGVD + + G G+   GS  I Q+    G P   AV + A++ +   V     +IA 
Sbjct: 292 LLEAGVDFIAIDGAGAASKGSPPIVQDDF--GVPTVYAVNRAATFLKKQGVKDRVSLIAG 349

Query: 359 GGIQSVGHIIKSLALGASTVMMGSL 383
           GG+ + G  +K LALGA  V +G++
Sbjct: 350 GGLVTPGDFLKILALGADAVYIGTI 374


>UniRef50_Q08PS9 Cluster: CBS; n=1; Stigmatella aurantiaca
           DW4/3-1|Rep: CBS - Stigmatella aurantiaca DW4/3-1
          Length = 142

 Score = 38.7 bits (86), Expect = 0.36
 Identities = 32/136 (23%), Positives = 67/136 (49%), Gaps = 13/136 (9%)

Query: 111 RDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLK 170
           RD   + P+ T+ D  +  ++ GF   P+    K+    IG++T RDI F+     L  +
Sbjct: 9   RDVTSIRPDQTLTDAAKHMRQQGFGLLPVCHVQKM----IGLLTDRDIVFQAIAERLDPQ 64

Query: 171 EVMTPINDMIT------AQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKA 224
           +  TP++D+++      A     L  A  ++ +    +LP+++    LV +++  D+ + 
Sbjct: 65  Q--TPVSDILSEGPPRYAFEDDELATAARLMTEHGLPRLPVLDRHQNLVGMVSLKDVSRE 122

Query: 225 R-SYPNASKDSNKQLL 239
             + P+ +  S ++LL
Sbjct: 123 EPAMPSRTDTSLEELL 138


>UniRef50_A3M1P1 Cluster: Magnesium and cobalt efflux protein; n=1;
           Acinetobacter baumannii ATCC 17978|Rep: Magnesium and
           cobalt efflux protein - Acinetobacter baumannii (strain
           ATCC 17978 / NCDC KC 755)
          Length = 234

 Score = 38.7 bits (86), Expect = 0.36
 Identities = 27/130 (20%), Positives = 56/130 (43%), Gaps = 2/130 (1%)

Query: 165 PHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINND--GELVALIARTDLK 222
           P   ++EVMTP   MI+ Q    L D  ++L +S   + P+ + D    +V ++   DL 
Sbjct: 9   PATKIREVMTPRTAMISMQEDDQLLDILHVLVESAHSRFPVFSADQPDNVVGILLAKDLL 68

Query: 223 KARSYPNASKDSNKQLLVGAAIGTRDTDRERLKLLVNNGVDVIVLDSSQGNSTYQIKMIK 282
              + PN   D    +     +       + L++L +    + ++    G++   + +  
Sbjct: 69  PFLTEPNTKLDIGSLMRQPLFVPESARSDQVLRMLKHTQTHIAIVIDEYGSTAGLVTLED 128

Query: 283 YIKETYPEIQ 292
            ++E   EI+
Sbjct: 129 ILEEIVGEIE 138


>UniRef50_A0HCZ3 Cluster: FMN-dependent alpha-hydroxy acid
           dehydrogenase; n=1; Comamonas testosteroni KF-1|Rep:
           FMN-dependent alpha-hydroxy acid dehydrogenase -
           Comamonas testosteroni KF-1
          Length = 380

 Score = 38.7 bits (86), Expect = 0.36
 Identities = 22/79 (27%), Positives = 41/79 (51%), Gaps = 2/79 (2%)

Query: 305 KNLIDAGVDALRVGMGSGSICITQEV--MACGCPQATAVYQVASYARHFNVPVIADGGIQ 362
           K L+ A   A  V +G+ +I ++     +      A  V      A   ++P++ DGG++
Sbjct: 253 KGLLSARAAAKAVELGADAIVVSNHGGRVLDSAVSALEVLPAIREATPAHIPLLMDGGVR 312

Query: 363 SVGHIIKSLALGASTVMMG 381
               ++K++ALGAS V++G
Sbjct: 313 QGTDVLKAIALGASAVLLG 331


>UniRef50_Q97U50 Cluster: Putative uncharacterized protein; n=1;
           Sulfolobus solfataricus|Rep: Putative uncharacterized
           protein - Sulfolobus solfataricus
          Length = 131

 Score = 38.7 bits (86), Expect = 0.36
 Identities = 31/116 (26%), Positives = 53/116 (45%), Gaps = 6/116 (5%)

Query: 111 RDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLK 170
           R+P+ + PE ++ D  +  K+       I        + IGIVT RDI  R     ++L 
Sbjct: 9   RNPLTVKPETSIRDAAKIMKRENLGSLIIVDETN---KPIGIVTERDI-LRAVADEVALD 64

Query: 171 EVMTPI--NDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKA 224
             ++ I    +IT      + +A  I+ ++    L ++   GELV +I+  D  KA
Sbjct: 65  SPVSTIMTRGLITIPPNKDVTEALIIMYQNNVRHLAVVGQSGELVGVISIRDAAKA 120


>UniRef50_Q8TXY3 Cluster: CBS domain-containing protein; n=1;
           Methanopyrus kandleri|Rep: CBS domain-containing protein
           - Methanopyrus kandleri
          Length = 278

 Score = 38.7 bits (86), Expect = 0.36
 Identities = 32/125 (25%), Positives = 58/125 (46%), Gaps = 17/125 (13%)

Query: 112 DPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFR------EGDP 165
           DP  +  + TV +  E      F   P+ +N    GRL G+VT+ D+         E  P
Sbjct: 154 DPETVPSDITVLEAAEIMVDREFRRLPVVEN----GRLCGLVTATDVLHHVSSMATETSP 209

Query: 166 HLSLKEVM-TPI-----NDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIART 219
             S++EVM  P+      D+IT +  V +++A   ++ +  G L ++    +++ +I   
Sbjct: 210 DASVEEVMDVPVEEIMTEDVITIEPDVNIEEAALTMKGANVGSL-VVTEGNDVIGIITER 268

Query: 220 DLKKA 224
           D+  A
Sbjct: 269 DIMYA 273



 Score = 35.5 bits (78), Expect = 3.4
 Identities = 32/123 (26%), Positives = 59/123 (47%), Gaps = 18/123 (14%)

Query: 114 VCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDI-DFREGDPH------ 166
           V M P  TV   ++   + GF   P+T+ G+L   L+GI+T +D+ D+  G+        
Sbjct: 15  VSMPPTATVKSAVDTMIRYGFRRIPVTEPGEL--ELVGIMTGKDVLDYLVGERRKIIERR 72

Query: 167 ---LSLKEVMTPINDMITAQLGV-----TLQDANYILEKSKKGKLPIINNDGELVALIAR 218
                L  +  P+  ++  ++ V     T++ A   + + + G LPI+  D +LV +I  
Sbjct: 73  YGSTFLPALHEPVRSLMRTEVYVITPYDTVRKAVRTMFEFEVGALPIV-KDKKLVGIITE 131

Query: 219 TDL 221
            D+
Sbjct: 132 RDI 134


>UniRef50_O26296 Cluster: Glutamate synthase (NADPH), alpha subunit;
           n=2; Methanobacteriaceae|Rep: Glutamate synthase
           (NADPH), alpha subunit - Methanobacterium
           thermoautotrophicum
          Length = 499

 Score = 38.7 bits (86), Expect = 0.36
 Identities = 24/75 (32%), Positives = 39/75 (52%), Gaps = 7/75 (9%)

Query: 312 VDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFN----VPVIADGGIQSVGHI 367
           VD ++ G G+G   +T+     G P   A+ +     +  N    V +IA GGI+S   +
Sbjct: 330 VDGMQGGTGAGPDVVTEH---SGIPTIAAIVEADEALKEVNLRDEVSLIAAGGIRSGADV 386

Query: 368 IKSLALGASTVMMGS 382
            K++ALGA  V +G+
Sbjct: 387 AKAIALGADAVYIGT 401


>UniRef50_A5UM30 Cluster: IMP dehydrogenase related protein; n=1;
           Methanobrevibacter smithii ATCC 35061|Rep: IMP
           dehydrogenase related protein - Methanobrevibacter
           smithii (strain PS / ATCC 35061 / DSM 861)
          Length = 272

 Score = 38.7 bits (86), Expect = 0.36
 Identities = 26/116 (22%), Positives = 56/116 (48%), Gaps = 7/116 (6%)

Query: 112 DPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGR-LIGIVTSRDIDFREGD------ 164
           D + +  +  ++D L+   KN  +  P+    K   R L+GI++ RD+  + G       
Sbjct: 10  DLITVDKDQKLSDGLKLLAKNDVSRLPVINTNKDHQRELVGIISERDVADKLGSSKYENM 69

Query: 165 PHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTD 220
           P   L      + D+I+    + L D   ++ ++  G +PI+++D  +V ++++ D
Sbjct: 70  PASRLHISSVMVKDVISVVETMDLADVANLMLENGIGSVPIVSDDDMMVGIVSKAD 125


>UniRef50_A0B5X2 Cluster: CBS domain containing membrane protein;
           n=1; Methanosaeta thermophila PT|Rep: CBS domain
           containing membrane protein - Methanosaeta thermophila
           (strain DSM 6194 / PT) (Methanothrixthermophila (strain
           DSM 6194 / PT))
          Length = 262

 Score = 38.7 bits (86), Expect = 0.36
 Identities = 26/87 (29%), Positives = 47/87 (54%), Gaps = 16/87 (18%)

Query: 146 GGRLIGIVTSRDI-----------DFREGDP---HLSLKEVMTPINDMITAQLGVTLQDA 191
           GG+L+GI+T RDI            +R+ +    +L + +VMT  +D+    +   L++ 
Sbjct: 163 GGKLVGILTERDIARALRAFRDLVSWRQQETRIKNLLVSDVMT--HDVKYVYVDTPLEEV 220

Query: 192 NYILEKSKKGKLPIINNDGELVALIAR 218
             I+ +  +G LP++N+DG L  +I R
Sbjct: 221 RRIILEENRGGLPVLNSDGTLAGMITR 247


>UniRef50_Q57837 Cluster: Putative zinc metalloprotease MJ0392; n=6;
           Methanococcales|Rep: Putative zinc metalloprotease
           MJ0392 - Methanococcus jannaschii
          Length = 339

 Score = 38.7 bits (86), Expect = 0.36
 Identities = 31/132 (23%), Positives = 59/132 (44%), Gaps = 14/132 (10%)

Query: 95  QANEVHKVKKYKHGFIRDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVT 154
           +   + K  K K     +PV + P+ ++ + L+   K+ + GYP+ +NGK    L+G + 
Sbjct: 212 EVETIFKNIKAKDIMTPNPVYVTPDMSIEEFLDFMLKHKYFGYPVVENGK----LVGCIG 267

Query: 155 SRDIDFREGDPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVA 214
             +I  +EG     +++ +    D           D   IL K        +   G+L  
Sbjct: 268 IGNIHKKEGTVRDYMEKPVVVSED----------TDIKEILRKMANTDRVFVVEGGKLKG 317

Query: 215 LIARTDLKKARS 226
           +I++TD+ +A S
Sbjct: 318 IISKTDILRAMS 329


>UniRef50_Q9KGA2 Cluster: BH0210 protein; n=7; Bacillaceae|Rep:
           BH0210 protein - Bacillus halodurans
          Length = 315

 Score = 38.3 bits (85), Expect = 0.48
 Identities = 23/80 (28%), Positives = 38/80 (47%), Gaps = 3/80 (3%)

Query: 314 ALRVGMGSGSICITQEVMACGC---PQATAVYQVASYARHFNVPVIADGGIQSVGHIIKS 370
           AL+       + + +   A G     + T    +   A+   VP+IA GG+ +   ++ +
Sbjct: 123 ALKAEQHGADVIVAEGFEAAGLNSSEELTTFTLIPQIAKAVTVPLIAAGGVGNGAGLLAA 182

Query: 371 LALGASTVMMGSLLAGTSEA 390
           L+LGA  V MG+ L  T EA
Sbjct: 183 LSLGAQGVQMGTRLIATKEA 202


>UniRef50_Q8F624 Cluster: L-lactate dehydrogenase; n=4;
           Leptospira|Rep: L-lactate dehydrogenase - Leptospira
           interrogans
          Length = 760

 Score = 38.3 bits (85), Expect = 0.48
 Identities = 25/99 (25%), Positives = 45/99 (45%), Gaps = 7/99 (7%)

Query: 287 TYPEIQVVGGNVVTRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVAS 346
           ++ ++  +   ++T   A+  IDAG D + V    G +           P    V     
Sbjct: 614 SFTKLPFIVKGIMTPQDAQLAIDAGADCIVVSNHGGRVLDDM-------PGTARVLSGIR 666

Query: 347 YARHFNVPVIADGGIQSVGHIIKSLALGASTVMMGSLLA 385
                 + ++ADGG++S   + K +ALGA TV++G  +A
Sbjct: 667 NVIGDKIQIVADGGVRSGMDVFKMIALGADTVLVGRPMA 705


>UniRef50_Q6AJC1 Cluster: Related to acetoin utilization protein;
           n=1; Desulfotalea psychrophila|Rep: Related to acetoin
           utilization protein - Desulfotalea psychrophila
          Length = 216

 Score = 38.3 bits (85), Expect = 0.48
 Identities = 35/146 (23%), Positives = 66/146 (45%), Gaps = 19/146 (13%)

Query: 112 DPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDI------DFREGDP 165
           +P+ + P   + +         F   P+  +G+   RL+GI+T RD+          G+ 
Sbjct: 10  EPLTIYPHTLLPEARGILDAFKFRHLPVVDDGQ---RLLGIITDRDLRSAYPSSLESGEE 66

Query: 166 HLS--LKEVMTPINDMITAQLG-----VTLQDANYILEKSKKGKLPIINNDGELVALIAR 218
                L    TP+++++T          TL DA ++ ++ K G +P++N+   +V + + 
Sbjct: 67  SSGKFLGVEKTPVSEIMTVNCATIHPQATLDDALFLFDREKVGGVPVVNDQDLVVGMFSI 126

Query: 219 TDLKKARSYPNASKDSNK-QLLVGAA 243
            DL  A  Y N    ++K   L+G A
Sbjct: 127 RDLIAA--YKNLFGVADKGSALIGIA 150


>UniRef50_Q5QUI2 Cluster: Signaling protein with a cAMP-binding, CBS
           domains and predicted nucleotidyltransferase domain;
           n=2; Idiomarina|Rep: Signaling protein with a
           cAMP-binding, CBS domains and predicted
           nucleotidyltransferase domain - Idiomarina loihiensis
          Length = 610

 Score = 38.3 bits (85), Expect = 0.48
 Identities = 31/121 (25%), Positives = 58/121 (47%), Gaps = 11/121 (9%)

Query: 113 PVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFR---EGDP-HLS 168
           PV +    +V +  +    +G +   +  + +L    +GI+T RD+  R   EG P  + 
Sbjct: 156 PVSLSSSTSVQEAAKLMASHGISSVLVVDDTQL----VGILTDRDLRNRVVAEGLPLDVR 211

Query: 169 LKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL-KKARSY 227
           +  VMT + + +      +L DA   +  S    LP++N+  + V ++  TDL ++ RS 
Sbjct: 212 VSSVMTQLPESVYENR--SLMDALTTMTSSNIHHLPVVNDQNQPVGMVTATDLIRQQRSD 269

Query: 228 P 228
           P
Sbjct: 270 P 270


>UniRef50_P74081 Cluster: PolyA polymerase; n=4; Cyanobacteria|Rep:
           PolyA polymerase - Synechocystis sp. (strain PCC 6803)
          Length = 942

 Score = 38.3 bits (85), Expect = 0.48
 Identities = 29/116 (25%), Positives = 54/116 (46%), Gaps = 9/116 (7%)

Query: 109 FIRDPV-CMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDID--FREGDP 165
           F+  PV  + P  T+        + G +G  +    +   +L+GI++ RD+D     G  
Sbjct: 334 FMSSPVRTIRPHTTIEQAQRVLFRYGHSGLTVVNQEE---KLVGIISRRDLDLALHHGFS 390

Query: 166 HLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
           H  +K  MT   ++ T      L     I+     G+LP+++ + +LV ++ RTD+
Sbjct: 391 HAPVKGYMT--RNVKTIAPDTPLPRIEAIMVADDVGRLPVMDQE-KLVGIVTRTDV 443


>UniRef50_Q3T556 Cluster: CBS domain-like protein; n=5;
           Bacteria|Rep: CBS domain-like protein -
           Acidithiobacillus caldus
          Length = 158

 Score = 38.3 bits (85), Expect = 0.48
 Identities = 20/60 (33%), Positives = 31/60 (51%), Gaps = 3/60 (5%)

Query: 112 DPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLKE 171
           +P+ + PE  VA++     ++   G P+T      GRL+GIVT  D+  R  D  L  +E
Sbjct: 10  NPIQIAPETAVAEIARILIEHRINGVPVTDTE---GRLLGIVTEGDLVHRAADERLEPRE 66


>UniRef50_Q11EL1 Cluster: CBS domain containing protein; n=13;
           Proteobacteria|Rep: CBS domain containing protein -
           Mesorhizobium sp. (strain BNC1)
          Length = 151

 Score = 38.3 bits (85), Expect = 0.48
 Identities = 27/116 (23%), Positives = 54/116 (46%), Gaps = 12/116 (10%)

Query: 111 RDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLK 170
           RD     P++T+ D      +      P+  N     RL+G++T RDI  R     L  +
Sbjct: 9   RDVRVASPDDTIEDAARIMAEIDAGSLPVGDND----RLVGMITDRDIAVRAVAKGLGPE 64

Query: 171 EVMTPINDMITAQLGVTLQDAN-----YILEKSKKGKLPIINNDGELVALIARTDL 221
               P++D++T ++    +D +     + +   +  +LP++N D  LV +++  D+
Sbjct: 65  ---CPVSDVMTREIRYCFEDEDTDDIAHNMADQQIRRLPVVNRDKRLVGILSLGDI 117


>UniRef50_A6LV86 Cluster: Sigma54 specific transcriptional
           regulator, Fis family; n=2; Clostridium|Rep: Sigma54
           specific transcriptional regulator, Fis family -
           Clostridium beijerinckii NCIMB 8052
          Length = 590

 Score = 38.3 bits (85), Expect = 0.48
 Identities = 28/118 (23%), Positives = 53/118 (44%), Gaps = 8/118 (6%)

Query: 104 KYKHGFIRDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDI-DFRE 162
           K K    +  + + P NT  +  +   +NG  G P+       G+LI IVT  D+     
Sbjct: 2   KVKELMTKKVLVLKPNNTFEEAAKLFIENGIDGAPVVDRD---GKLISIVTKTDLMKAIL 58

Query: 163 GDPHLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTD 220
               ++ K     +  +IT    + ++D    + K   G+LP+I+ + +++ +I  TD
Sbjct: 59  NKLEMNTKLETLELKKVITINSEMNIED----VLKYNVGRLPVIDKNNKIIGIITHTD 112


>UniRef50_A5URS3 Cluster: CBS domain containing protein; n=4;
           Chloroflexaceae|Rep: CBS domain containing protein -
           Roseiflexus sp. RS-1
          Length = 162

 Score = 38.3 bits (85), Expect = 0.48
 Identities = 25/95 (26%), Positives = 48/95 (50%), Gaps = 2/95 (2%)

Query: 139 ITQNGKLGGRLIGIVTSRDIDFREGDPHLSLKEVMTPINDMITAQLGVTLQDANYILEKS 198
           ITQ    G  L+ +      D  +    + + EVM+   D IT     +L++A  ++ ++
Sbjct: 65  ITQGDIRGADLLRVAGMDPFDIADALRRIKVYEVMS--EDPITVTPETSLREAAMLMIEN 122

Query: 199 KKGKLPIINNDGELVALIARTDLKKARSYPNASKD 233
           K G LP+++ +  +V +I  +DL +A  +   S+D
Sbjct: 123 KIGGLPVVDENRMVVGIITESDLFEALVHVLESRD 157


>UniRef50_A4M3K4 Cluster: CBS domain containing membrane protein;
           n=3; Bacteria|Rep: CBS domain containing membrane
           protein - Geobacter bemidjiensis Bem
          Length = 216

 Score = 38.3 bits (85), Expect = 0.48
 Identities = 40/172 (23%), Positives = 73/172 (42%), Gaps = 17/172 (9%)

Query: 112 DPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLK- 170
           +P+ + P+ +V + L           P+ +     G+L+GIV+ RD+      P  SL  
Sbjct: 10  NPITITPDISVTEALRLMGDKKIRRLPVVERT---GKLVGIVSDRDLFQASPSPATSLAI 66

Query: 171 -EV----------MTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIART 219
            E+           T   D+IT      L++A  ++   + G LP++  D  LV +I  +
Sbjct: 67  WEIHDLLAKLTVDKTMATDVITVTEDTPLEEAARVMVDRRIGGLPVMKGDA-LVGIITES 125

Query: 220 DLKKARSYPNASKDSNKQLLVGAAIGTRDTDRERLKLLVNNGVDVIVLDSSQ 271
           DL +A       +    +L V    G + T  +  + +   G D++ L  S+
Sbjct: 126 DLFQALLELLGGRRHGVRLTV-TTTGAKGTLADVAQTIYQAGGDIVGLGFSE 176


>UniRef50_A3ZL92 Cluster: Putative uncharacterized protein; n=1;
           Blastopirellula marina DSM 3645|Rep: Putative
           uncharacterized protein - Blastopirellula marina DSM
           3645
          Length = 363

 Score = 38.3 bits (85), Expect = 0.48
 Identities = 28/80 (35%), Positives = 42/80 (52%), Gaps = 7/80 (8%)

Query: 147 GRLIGIVTSRDID--FREGDPHL---SLKEVMTPINDMITAQLGVTLQDANYILEKSKKG 201
           G+L GI T  D+   F  G   L    +  VMT     +T+  GV + +A   + KSK  
Sbjct: 253 GKLAGIFTDSDLARIFETGRTELLDQPISIVMTQSPKTVTS--GVRVLEALSAIAKSKIS 310

Query: 202 KLPIINNDGELVALIARTDL 221
           +LP+IN+ GE + ++  TDL
Sbjct: 311 ELPVINDTGEPIGMLDITDL 330


>UniRef50_O27702 Cluster: Glutamate synthase (NADPH), alpha subunit
           related protein; n=1; Methanothermobacter
           thermautotrophicus str. Delta H|Rep: Glutamate synthase
           (NADPH), alpha subunit related protein -
           Methanobacterium thermoautotrophicum
          Length = 383

 Score = 38.3 bits (85), Expect = 0.48
 Identities = 30/93 (32%), Positives = 47/93 (50%), Gaps = 8/93 (8%)

Query: 296 GNVVTRMQAKNLIDAGVDALRV-GMGSGSICITQEVMA-CGCPQATAVYQ----VASYAR 349
           GNV   ++A  L+DAGVD + + G G G+  +   +    G P   A+ +    V +   
Sbjct: 229 GNVEDDVKA--LLDAGVDFISLDGFGGGTGAVNPHIRDNTGIPLIAAIPRAVKTVINEGH 286

Query: 350 HFNVPVIADGGIQSVGHIIKSLALGASTVMMGS 382
              V +IA GG+++   + K LALGA  V  G+
Sbjct: 287 GDRVSLIAGGGLRTAADMAKCLALGADAVYTGT 319


>UniRef50_A3CWH3 Cluster: CBS domain containing protein; n=1;
           Methanoculleus marisnigri JR1|Rep: CBS domain containing
           protein - Methanoculleus marisnigri (strain ATCC 35101 /
           DSM 1498 / JR1)
          Length = 279

 Score = 38.3 bits (85), Expect = 0.48
 Identities = 27/110 (24%), Positives = 47/110 (42%), Gaps = 6/110 (5%)

Query: 112 DPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLKE 171
           +P+ + PE  + D+         +G P+   GK+     GIVT  D+  R         +
Sbjct: 80  EPITIAPETGIRDIAAIMLDRDISGLPVVNEGKVS----GIVTKLDL-MRSAHIRGLTAQ 134

Query: 172 VMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
           V   + D  T     +L      + K K  KL ++N++G L  +I  ++L
Sbjct: 135 VSEIMEDAATVNRYHSLDHVIDTI-KGKNDKLIVVNDNGSLAGIITESNL 183


>UniRef50_Q97EU8 Cluster: CBS domain containing protein; n=1;
           Clostridium acetobutylicum|Rep: CBS domain containing
           protein - Clostridium acetobutylicum
          Length = 133

 Score = 37.9 bits (84), Expect = 0.63
 Identities = 25/66 (37%), Positives = 38/66 (57%), Gaps = 2/66 (3%)

Query: 173 MTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL-KKARSYPNAS 231
           +TP   ++ A+L  TL+ A   ++  K  +L I+N+ GE V  I + DL KK ++ PN  
Sbjct: 7   ITPKKQVVYAKLTSTLRQAFERMKYYKCHELIILNDKGEYVGFITKEDLVKKIKNSPNLH 66

Query: 232 -KDSNK 236
            KD NK
Sbjct: 67  LKDFNK 72


>UniRef50_Q3J9M3 Cluster: CBS domain containing protein; n=1;
           Nitrosococcus oceani ATCC 19707|Rep: CBS domain
           containing protein - Nitrosococcus oceani (strain ATCC
           19707 / NCIMB 11848)
          Length = 286

 Score = 37.9 bits (84), Expect = 0.63
 Identities = 32/106 (30%), Positives = 59/106 (55%), Gaps = 13/106 (12%)

Query: 123 ADVLEAKK--KNGFTGYPITQNGKLGGRLIGIVTSRDIDFR----EGDP-HLSLKEVMTP 175
           + VLEA +  +N   G  + Q+    GR++GIVT RD+  R    + DP + ++ EVMTP
Sbjct: 18  SSVLEAARAMENNSIGAIVVQDH---GRIVGIVTDRDLAVRALGHKLDPENTAITEVMTP 74

Query: 176 INDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
              M+T  L  + ++A  ++++    ++P+  N+  +V ++   DL
Sbjct: 75  SPLMLT--LADSREEAIALMQQGNVRRIPLSENN-RVVGMVTLDDL 117


>UniRef50_Q8GA65 Cluster: Putative FMN-dependent dehydrogenase; n=4;
           Escherichia coli|Rep: Putative FMN-dependent
           dehydrogenase - Escherichia coli
          Length = 405

 Score = 37.9 bits (84), Expect = 0.63
 Identities = 31/102 (30%), Positives = 52/102 (50%), Gaps = 10/102 (9%)

Query: 281 IKYIKETYPEIQVVGGNVVTRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATA 340
           I+++K+    + V+   ++    A   IDAG DA++V    G           G P A +
Sbjct: 260 IEFVKKI-TGLPVIVKGILRGEDAVVAIDAGADAIQVSNHGGR-------QIDGVPSAIS 311

Query: 341 VYQ-VASYARHFNVPVIADGGIQSVGHIIKSLALGASTVMMG 381
             Q VA+   H  VPVI D GI+    ++++++LGA+ V +G
Sbjct: 312 QLQEVAARVGH-KVPVIFDSGIRRGIDVVRAISLGATAVAVG 352


>UniRef50_Q3RE81 Cluster: 2-nitropropane dioxygenase, NPD precursor;
           n=6; Bacteria|Rep: 2-nitropropane dioxygenase, NPD
           precursor - Xylella fastidiosa Dixon
          Length = 343

 Score = 37.9 bits (84), Expect = 0.63
 Identities = 43/163 (26%), Positives = 70/163 (42%), Gaps = 9/163 (5%)

Query: 244 IGTRDTDRERLKLLVNNGVDVIVLDSSQGNSTYQIKMIKYIKETYPEIQVVGGNVVTRMQ 303
           +G  D   ++L LL+N+ V V+       + T+ +  ++ I         V  +V    +
Sbjct: 106 MGDDDGWPDKLALLLNDPVPVV-------SFTFGLPAVRDIAALRCAGSRVLASVTLPAE 158

Query: 304 AKNLIDAGVDALRV-GMGSGSICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQ 362
           A+  ++AGVD L V G  +G    T +      P  T V  V       ++PVIA GG+ 
Sbjct: 159 AQAAMEAGVDGLVVQGPDAGGHSATYDPGRPFTPLKT-VSLVRRVCAVSSLPVIAAGGVD 217

Query: 363 SVGHIIKSLALGASTVMMGSLLAGTSEAPGEYFFSDGVRLKKY 405
               +   L  GA+ V +G+LL  T E+       D +    Y
Sbjct: 218 GPVMVRALLQAGAAAVAIGTLLLRTKESGATQVHKDALANPAY 260


>UniRef50_A4WYL0 Cluster: Putative uncharacterized protein; n=1;
           Rhodobacter sphaeroides ATCC 17025|Rep: Putative
           uncharacterized protein - Rhodobacter sphaeroides ATCC
           17025
          Length = 139

 Score = 37.9 bits (84), Expect = 0.63
 Identities = 29/108 (26%), Positives = 57/108 (52%), Gaps = 11/108 (10%)

Query: 119 ENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFR---EG-DPHLS-LKEVM 173
           +  V++V    K +     P+ ++     RLIG++T RD+  R   EG DP  +   +VM
Sbjct: 17  DTPVSEVARQMKADDIGALPVGRDD----RLIGMITDRDLVLRVLAEGRDPKTTKASDVM 72

Query: 174 TPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
           T    ++  +    + DA + +E+ +  +LP+I+++  LV ++A  D+
Sbjct: 73  T--EGIVWCRTSQPISDAIHQMEERRIRRLPVIDDNKRLVGMLALGDI 118


>UniRef50_A4M6L8 Cluster: 2-nitropropane dioxygenase, NPD; n=2;
           Bacteria|Rep: 2-nitropropane dioxygenase, NPD -
           Petrotoga mobilis SJ95
          Length = 317

 Score = 37.9 bits (84), Expect = 0.63
 Identities = 27/78 (34%), Positives = 39/78 (50%), Gaps = 3/78 (3%)

Query: 314 ALRVGMGSGSICITQEVMACG--CPQATAVYQVASYARHFNVPVIADGGIQSVGHIIKSL 371
           ALR+   +G+  I  E M CG      T +  V   +   +VPVIA GGI +    + +L
Sbjct: 126 ALRLE-NAGAEAIIGEGMECGGHIGDVTTMVLVPKLSSILSVPVIAAGGIANGPGAVAAL 184

Query: 372 ALGASTVMMGSLLAGTSE 389
           +LGA  + MG+    T E
Sbjct: 185 SLGAEGIQMGTRFIATYE 202


>UniRef50_A1IEP7 Cluster: Putative uncharacterized protein; n=1;
           Candidatus Desulfococcus oleovorans Hxd3|Rep: Putative
           uncharacterized protein - Candidatus Desulfococcus
           oleovorans Hxd3
          Length = 355

 Score = 37.9 bits (84), Expect = 0.63
 Identities = 21/72 (29%), Positives = 33/72 (45%)

Query: 320 GSGSICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQSVGHIIKSLALGASTVM 379
           G+ ++ +T    A       ++  +       N+PVIA GGI     +  +L LGA  V 
Sbjct: 138 GADALIVTGHEAAAHGGAVASMVLIPGIVDRVNIPVIAAGGIADGRGLAAALVLGAEGVA 197

Query: 380 MGSLLAGTSEAP 391
           MG+    T E+P
Sbjct: 198 MGTRFMNTRESP 209


>UniRef50_A1I7E2 Cluster: 2-nitropropane dioxygenase, NPD; n=1;
           Candidatus Desulfococcus oleovorans Hxd3|Rep:
           2-nitropropane dioxygenase, NPD - Candidatus
           Desulfococcus oleovorans Hxd3
          Length = 322

 Score = 37.9 bits (84), Expect = 0.63
 Identities = 21/48 (43%), Positives = 25/48 (52%)

Query: 344 VASYARHFNVPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEAP 391
           V S      VPVI  GG+     ++  LALGA  V+MGS L  T E P
Sbjct: 163 VPSVVDAVKVPVIGGGGVSDGRGLLAVLALGAGAVIMGSRLLVTRECP 210


>UniRef50_O29411 Cluster: Inosine monophosphate dehydrogenase; n=1;
           Archaeoglobus fulgidus|Rep: Inosine monophosphate
           dehydrogenase - Archaeoglobus fulgidus
          Length = 189

 Score = 37.9 bits (84), Expect = 0.63
 Identities = 28/80 (35%), Positives = 44/80 (55%), Gaps = 7/80 (8%)

Query: 147 GRLIGIVTSRD----IDFREGDPHLSL-KEVMTPINDMITAQLGVTLQDANYILEKSKKG 201
           GR +GIVT +D    I  R   P   L +EVM+    +IT     +L++A  I+ K    
Sbjct: 45  GRPVGIVTEKDLISKIVARNKVPSKVLVEEVMS--QPVITIGPNTSLREAARIMMKRGIR 102

Query: 202 KLPIINNDGELVALIARTDL 221
           +LP++NN+ EL+ +I   D+
Sbjct: 103 RLPVVNNNQELIGIITDNDI 122


>UniRef50_Q58410 Cluster: Uncharacterized protein MJ1004; n=6;
           Methanococcales|Rep: Uncharacterized protein MJ1004 -
           Methanococcus jannaschii
          Length = 214

 Score = 37.9 bits (84), Expect = 0.63
 Identities = 26/106 (24%), Positives = 46/106 (43%), Gaps = 4/106 (3%)

Query: 119 ENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDI-DFREGDPHLSLKEVMTPIN 177
           + TV D +   KK      PI        RL+G VT+ ++    E D    + E M P+ 
Sbjct: 17  DETVEDAINLLKKKKRFSAPIVDKED---RLVGWVTTLELLGISEKDFKKPITEFMRPVE 73

Query: 178 DMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKK 223
           ++IT       ++      K K   +P++  DG ++ ++   D+ K
Sbjct: 74  EVITVYEDDEARNVVLKFVKYKVVSIPVLTRDGRVIGMVRNCDVVK 119


>UniRef50_A3CTR9 Cluster:
           1-(5-phosphoribosyl)-5-[(5-
           phosphoribosylamino)methylideneamino]
           imidazole-4-carboxamide isomerase; n=4;
           Methanomicrobiales|Rep:
           1-(5-phosphoribosyl)-5-[(5-
           phosphoribosylamino)methylideneamino]
           imidazole-4-carboxamide isomerase - Methanoculleus
           marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
          Length = 239

 Score = 37.9 bits (84), Expect = 0.63
 Identities = 25/74 (33%), Positives = 34/74 (45%), Gaps = 2/74 (2%)

Query: 319 MGSGSICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQSVGHIIKSLALGASTV 378
           +G+GS+  T  V   G  Q  A+  V        VPV+  GGI S G +      GA+  
Sbjct: 157 LGAGSLLYTN-VDVEGLQQGIAIEPVTELLARVKVPVVVSGGISSPGDVAALRDAGAAGA 215

Query: 379 MMGS-LLAGTSEAP 391
           ++GS L AG    P
Sbjct: 216 VLGSALYAGKVRLP 229


>UniRef50_UPI00015BAEC4 Cluster: putative signal-transduction
           protein with CBS domains; n=1; Ignicoccus hospitalis
           KIN4/I|Rep: putative signal-transduction protein with
           CBS domains - Ignicoccus hospitalis KIN4/I
          Length = 131

 Score = 37.5 bits (83), Expect = 0.84
 Identities = 30/124 (24%), Positives = 62/124 (50%), Gaps = 6/124 (4%)

Query: 102 VKKYKHGFIRDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFR 161
           ++KY  G  R  + +  E T+ + +E   +NG     +T+  + G    G++T RD+   
Sbjct: 4   IEKY-FGRERMIITIDEEATIGEAVELMHENGIGALLVTREEEGGVAAAGLLTERDVIAA 62

Query: 162 ---EGDPH-LSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIA 217
                DP+   +K  MTP  D+IT      +++A  I+ ++    L +++ + +++ +I+
Sbjct: 63  LALGADPNRAKVKYYMTPWKDVITVTPETPIKEALRIMIENGIRHLVVVSGE-KVLGIIS 121

Query: 218 RTDL 221
             DL
Sbjct: 122 MRDL 125


>UniRef50_Q9K9P0 Cluster: BH2605 protein; n=6; Bacteria|Rep: BH2605
           protein - Bacillus halodurans
          Length = 142

 Score = 37.5 bits (83), Expect = 0.84
 Identities = 29/108 (26%), Positives = 59/108 (54%), Gaps = 11/108 (10%)

Query: 118 PENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFR---EGDPHLS-LKEVM 173
           P++ + +V    +++     PI +  +L    +G+VT RDI  R   +  P+ + +KEVM
Sbjct: 17  PDDNIFEVAVKMERDNVGAVPICEEEQL----LGMVTDRDIVIRSVAKKKPNSTPVKEVM 72

Query: 174 TPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
           +    ++TA   +T+Q+A  ++   +  +LP++ N+  LV + +  DL
Sbjct: 73  S--EHLVTATPDMTVQEAAKLMATKQIRRLPVVENN-RLVGICSLGDL 117


>UniRef50_Q3WH73 Cluster: CBS domain; n=2; Frankia|Rep: CBS domain -
           Frankia sp. EAN1pec
          Length = 139

 Score = 37.5 bits (83), Expect = 0.84
 Identities = 32/118 (27%), Positives = 52/118 (44%), Gaps = 8/118 (6%)

Query: 111 RDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFR---EG-DPH 166
           R+P  +G +  +A+     K        +  N    GR+ GIVT RDI  R   EG DP 
Sbjct: 11  RNPATVGMDQPIAEAARRMKTVNAGDVIVLDNT---GRVAGIVTDRDITLRVVAEGRDPE 67

Query: 167 LSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKA 224
            +    +     +IT     T   A  ++ +    +LP+++  G  V +I+  DL +A
Sbjct: 68  RTATREVCTQTGLITIAPDTTTDTAVQLIRERHIRRLPVVDK-GRPVGVISLGDLARA 124


>UniRef50_Q122S0 Cluster: 2-nitropropane dioxygenase, NPD; n=68;
           Betaproteobacteria|Rep: 2-nitropropane dioxygenase, NPD
           - Polaromonas sp. (strain JS666 / ATCC BAA-500)
          Length = 422

 Score = 37.5 bits (83), Expect = 0.84
 Identities = 22/61 (36%), Positives = 31/61 (50%), Gaps = 2/61 (3%)

Query: 336 PQATAVYQVASYARHFNVPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEAPGEYF 395
           PQ    ++ A   R   +P+IA GGI     I++  ALGAS V +G+  A T E   +  
Sbjct: 234 PQVLEFFKTAGIERE--IPLIAAGGINCRDDILRLQALGASAVQLGTAFAVTLECDADPA 291

Query: 396 F 396
           F
Sbjct: 292 F 292


>UniRef50_Q0VMM0 Cluster: 2-nitropropane dioxygenase, putative; n=1;
           Alcanivorax borkumensis SK2|Rep: 2-nitropropane
           dioxygenase, putative - Alcanivorax borkumensis (strain
           SK2 / ATCC 700651 / DSM 11573)
          Length = 333

 Score = 37.5 bits (83), Expect = 0.84
 Identities = 17/39 (43%), Positives = 25/39 (64%)

Query: 352 NVPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEA 390
           +VPV+A GGI S G ++ + ++GA  V +GS    T EA
Sbjct: 173 DVPVVASGGIASGGAMLAAFSMGAQGVSLGSAFLATHEA 211


>UniRef50_Q0AHF1 Cluster: Putative signal-transduction protein with
           CBS domains; n=2; Nitrosomonadaceae|Rep: Putative
           signal-transduction protein with CBS domains -
           Nitrosomonas eutropha (strain C71)
          Length = 149

 Score = 37.5 bits (83), Expect = 0.84
 Identities = 24/82 (29%), Positives = 44/82 (53%), Gaps = 7/82 (8%)

Query: 150 IGIVTSRDIDFREGDPHLSLKEVMTPINDMITAQL-----GVTLQDANYILEKSKKGKLP 204
           +G++T RD+        L  KE +T ++D++T +L        + DA   + +    +LP
Sbjct: 48  VGVITDRDLVVEVLATGLD-KEAIT-VDDVMTQELFAVKENTAIHDAINFMRRKTIRRLP 105

Query: 205 IINNDGELVALIARTDLKKARS 226
           IIN++GELV ++   D+ +  S
Sbjct: 106 IINDNGELVGILTTDDIMEILS 127


>UniRef50_A1SM43 Cluster: 2-nitropropane dioxygenase, NPD; n=1;
           Nocardioides sp. JS614|Rep: 2-nitropropane dioxygenase,
           NPD - Nocardioides sp. (strain BAA-499 / JS614)
          Length = 328

 Score = 37.5 bits (83), Expect = 0.84
 Identities = 32/108 (29%), Positives = 49/108 (45%), Gaps = 8/108 (7%)

Query: 294 VGGNVVTRMQAKNLIDAGVDALRV-GMGSGSICITQEVMACGCPQATAVYQVASYARHFN 352
           V   V T  +A+  + AGVD L V G+ +G   +  E +A   P+   V  VA       
Sbjct: 110 VFATVGTAQEARAALAAGVDGLVVQGLEAGGHLVGVEPLAAALPR---VLDVAGD----K 162

Query: 353 VPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEAPGEYFFSDGV 400
           VPV+A GG+     + + L  GAS  + G+    T E+     + + V
Sbjct: 163 VPVLAAGGVADSADVRRLLESGASAAVAGTRFLLTDESAAHPVYKERV 210


>UniRef50_Q6C9A7 Cluster: Similar to sp|Q9WU19 Mus musculus
           Hydroxyacid oxidase 1; n=1; Yarrowia lipolytica|Rep:
           Similar to sp|Q9WU19 Mus musculus Hydroxyacid oxidase 1
           - Yarrowia lipolytica (Candida lipolytica)
          Length = 382

 Score = 37.5 bits (83), Expect = 0.84
 Identities = 30/91 (32%), Positives = 41/91 (45%), Gaps = 7/91 (7%)

Query: 291 IQVVGGNVVTRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARH 350
           +Q+    VVT       I+AGVD + V    G        +  G     A+ +V   A  
Sbjct: 243 MQIWVKGVVTAEDTHAAIEAGVDGIWVSNHGG------RQLDSGLATIDALPEVVEAAAG 296

Query: 351 FNVPVIADGGIQSVGHIIKSLALGASTVMMG 381
             VP+  DGGI+  G + K LALGA  V +G
Sbjct: 297 -RVPIHIDGGIRRGGDVFKCLALGADFVWLG 326


>UniRef50_Q6LXU6 Cluster: Putative uncharacterized protein; n=5;
           Methanococcus|Rep: Putative uncharacterized protein -
           Methanococcus maripaludis
          Length = 186

 Score = 37.5 bits (83), Expect = 0.84
 Identities = 30/108 (27%), Positives = 51/108 (47%), Gaps = 7/108 (6%)

Query: 119 ENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLKEVMT---P 175
           + T  DV    K+ G  G  +  N    G+ +GI+T RD+       +L  KEV+     
Sbjct: 21  DTTAYDVANILKEKGI-GCLVVLND--AGKPVGIITERDLALGVVSRNLKSKEVIVEEIS 77

Query: 176 INDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKK 223
            + +I      TL DA   ++     +LP+I+ D EL+ ++  +D+ K
Sbjct: 78  SSKLIAIAPKSTLMDAARKMDTENVKRLPVIDGD-ELLGIVTVSDITK 124


>UniRef50_Q4JBX5 Cluster: Conserved CBS domain protein; n=2;
           Sulfolobus|Rep: Conserved CBS domain protein -
           Sulfolobus acidocaldarius
          Length = 131

 Score = 37.5 bits (83), Expect = 0.84
 Identities = 29/117 (24%), Positives = 53/117 (45%), Gaps = 8/117 (6%)

Query: 111 RDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDP---HL 167
           R PV +  + ++ D  +  ++ G     I  N     R +GIVT RDI +          
Sbjct: 9   RKPVTVDLKTSIKDATKVMRREGVGSLVIVDNDF---RPVGIVTERDIVYAIAQDIPIDT 65

Query: 168 SLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKA 224
            + E+M+   D ++   G  + +A  ++       L +INN+G  + +I+  D+ KA
Sbjct: 66  PISEIMS--RDPVSINGGSDVSEAVALMTSRGIRHLVVINNEGRTIGVISVRDVVKA 120


>UniRef50_Q4JAS3 Cluster: Protein pcrB homolog; n=4;
           Sulfolobaceae|Rep: Protein pcrB homolog - Sulfolobus
           acidocaldarius
          Length = 257

 Score = 37.5 bits (83), Expect = 0.84
 Identities = 21/60 (35%), Positives = 35/60 (58%), Gaps = 2/60 (3%)

Query: 261 GVDVIVLDSSQGNS-TYQIKMIKYIKETYPE-IQVVGGNVVTRMQAKNLIDAGVDALRVG 318
           G+  I L++  G S T + + IK +K T  + + +VGG V +  +A+NL+ AG D +  G
Sbjct: 170 GMKYIYLEAGSGASETVKPEAIKVVKNTVKDGVVIVGGGVTSEERARNLVLAGADIIVTG 229


>UniRef50_A4FVH7 Cluster: Hao1 protein; n=9; Deuterostomia|Rep: Hao1
           protein - Danio rerio (Zebrafish) (Brachydanio rerio)
          Length = 369

 Score = 37.1 bits (82), Expect = 1.1
 Identities = 35/126 (27%), Positives = 54/126 (42%), Gaps = 8/126 (6%)

Query: 273 NSTYQIKMIKYIKETYPEIQVVGGNVVTRMQAKNLIDAGVDALRVGMGSGSICITQEVMA 332
           ++T + + I ++K T  ++ VV   V+T   AK  +  GVD + V               
Sbjct: 214 DATVRWQDIGWLK-TLTKLPVVVKGVLTAEDAKEALKYGVDGILVSNHGARQLDGVPATI 272

Query: 333 CGCPQATAVYQVASYARHFNVPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEAPG 392
              P+  A   VA       V V  DGG++    ++K+LALGA  V +G  +       G
Sbjct: 273 DALPEVVAA--VAG-----QVEVFMDGGVRMGSDVLKALALGAKAVFIGRPVLWALACQG 325

Query: 393 EYFFSD 398
           E   SD
Sbjct: 326 EKGVSD 331


>UniRef50_Q9KDK7 Cluster: BH1205 protein; n=2; Bacillus|Rep: BH1205
           protein - Bacillus halodurans
          Length = 365

 Score = 37.1 bits (82), Expect = 1.1
 Identities = 18/41 (43%), Positives = 25/41 (60%)

Query: 350 HFNVPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEA 390
           H  VPV+A GG+     ++ +LALGA+ V MG+    T EA
Sbjct: 208 HVQVPVVAAGGVVDGRGLVAALALGAAGVQMGTRFLLTKEA 248


>UniRef50_Q98DX5 Cluster: Cysteine synthase; n=42; Bacteria|Rep:
           Cysteine synthase - Rhizobium loti (Mesorhizobium loti)
          Length = 479

 Score = 37.1 bits (82), Expect = 1.1
 Identities = 30/113 (26%), Positives = 53/113 (46%), Gaps = 7/113 (6%)

Query: 112 DPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLKE 171
           D V +GP+ ++ +     +++  +  P+ ++GK    LIGIV   DI  +   P+    E
Sbjct: 363 DTVYVGPDESLLNAYGRMRRSDVSQLPVLEDGK----LIGIVDESDILAKVDGPYDGRWE 418

Query: 172 VMT-PINDMITAQLGV--TLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
               P+   +T+ L      Q  + +L    + ++ II +  E V LI R DL
Sbjct: 419 RFNGPVRTAMTSNLHTLQASQTLDALLPVFDRNEVAIIFDGDEFVGLITRIDL 471


>UniRef50_Q98DF1 Cluster: Glycolate oxidase (S)-2-hydroxy-acid
           oxidase, peroxisomal; n=1; Mesorhizobium loti|Rep:
           Glycolate oxidase (S)-2-hydroxy-acid oxidase,
           peroxisomal - Rhizobium loti (Mesorhizobium loti)
          Length = 352

 Score = 37.1 bits (82), Expect = 1.1
 Identities = 14/29 (48%), Positives = 23/29 (79%)

Query: 353 VPVIADGGIQSVGHIIKSLALGASTVMMG 381
           +P+I DGG++    ++K++ALGAS VM+G
Sbjct: 277 IPIILDGGVRRGTDVLKAIALGASAVMIG 305


>UniRef50_Q8NQY4 Cluster: Predicted signal-transduction protein
           containing cAMP-binding and CBS domains; n=3;
           Corynebacterium|Rep: Predicted signal-transduction
           protein containing cAMP-binding and CBS domains -
           Corynebacterium glutamicum (Brevibacterium flavum)
          Length = 622

 Score = 37.1 bits (82), Expect = 1.1
 Identities = 30/118 (25%), Positives = 58/118 (49%), Gaps = 11/118 (9%)

Query: 110 IRDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFR----EGDP 165
           I +P+   P+ T+ D      + G +   +    ++ G L GI+T RD+  R    + D 
Sbjct: 162 IANPISCSPDTTIMDAAIKMDEFGVSSLLV----QIDGELKGIITDRDMRSRVVAKDLDI 217

Query: 166 HLSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKK 223
            L + EVMT      T+Q G+   +A  ++ + +   LPI+ +DG++  ++   D+ +
Sbjct: 218 QLPVSEVMTVDPRCATSQ-GLAF-EAMLLMSELRIHHLPIV-DDGQISGIVTAADIMR 272


>UniRef50_Q8DHZ1 Cluster: CBS domain protein; n=1; Synechococcus
           elongatus|Rep: CBS domain protein - Synechococcus
           elongatus (Thermosynechococcus elongatus)
          Length = 156

 Score = 37.1 bits (82), Expect = 1.1
 Identities = 20/63 (31%), Positives = 36/63 (57%), Gaps = 2/63 (3%)

Query: 169 LKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDLKKARSYP 228
           +++VMTP  +  T  +   + +A  ++      +LP++N+ GELV +I+R DL +A    
Sbjct: 95  VQDVMTP--NPHTINVDAPISEAARLMVNHHISRLPVLNDQGELVGIISRHDLLRALHAQ 152

Query: 229 NAS 231
            AS
Sbjct: 153 EAS 155


>UniRef50_Q8CXK9 Cluster: Glutamate synthase (NADPH) large (Alpha)
           subunit; n=1; Oceanobacillus iheyensis|Rep: Glutamate
           synthase (NADPH) large (Alpha) subunit - Oceanobacillus
           iheyensis
          Length = 482

 Score = 37.1 bits (82), Expect = 1.1
 Identities = 27/99 (27%), Positives = 48/99 (48%), Gaps = 8/99 (8%)

Query: 295 GGNVVTRMQAKNLIDAGVDALRVGMGSGSICITQEVMA--CGCPQATAVYQVASYARHFN 352
           GG +   + A  L++ GVD + V  G  +      ++    G P   A+ +  ++    N
Sbjct: 275 GGKIEDDIDA--LLEIGVDYIAVDGGQAATYGAAPLLTDDFGIPTLHALIRAVNHLEKIN 332

Query: 353 ----VPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGT 387
               + +I  GG+ + G  +K+LALGA  V +GS++  T
Sbjct: 333 KKNEISLIISGGMFTPGEYLKALALGADAVYLGSVMLFT 371


>UniRef50_Q5LKQ6 Cluster: Oxidoreductase, 2-nitropropane dioxygenase
           family; n=1; Silicibacter pomeroyi|Rep: Oxidoreductase,
           2-nitropropane dioxygenase family - Silicibacter
           pomeroyi
          Length = 358

 Score = 37.1 bits (82), Expect = 1.1
 Identities = 19/38 (50%), Positives = 23/38 (60%)

Query: 353 VPVIADGGIQSVGHIIKSLALGASTVMMGSLLAGTSEA 390
           VPV+A GGI     I  +LALGAS   MG+    T+EA
Sbjct: 210 VPVVASGGITDGRGIAAALALGASAAQMGTAFLTTTEA 247


>UniRef50_Q3A5H4 Cluster: Putative Fe-S oxidoreductase; n=1;
           Pelobacter carbinolicus DSM 2380|Rep: Putative Fe-S
           oxidoreductase - Pelobacter carbinolicus (strain DSM
           2380 / Gra Bd 1)
          Length = 425

 Score = 37.1 bits (82), Expect = 1.1
 Identities = 23/85 (27%), Positives = 38/85 (44%), Gaps = 1/85 (1%)

Query: 248 DTDRERLKLLVNNGVDVIVLDSSQGNSTYQIKMIKYIKETYPE-IQVVGGNVVTRMQAKN 306
           DT     K +++N +DV+ +           + I   K+  P+ I VVGG ++T      
Sbjct: 46  DTKESLKKKIIDNNIDVLCIGGLSDQYNEIKRTIDLSKQIKPDLIIVVGGGLITAQPTLI 105

Query: 307 LIDAGVDALRVGMGSGSICITQEVM 331
           + + G D   VG G  +IC   E +
Sbjct: 106 MENIGADYAIVGQGEITICELAEAL 130


>UniRef50_Q21UP4 Cluster: Putative signal-transduction protein with
           CBS domains; n=1; Rhodoferax ferrireducens T118|Rep:
           Putative signal-transduction protein with CBS domains -
           Rhodoferax ferrireducens (strain DSM 15236 / ATCC
           BAA-621 / T118)
          Length = 146

 Score = 37.1 bits (82), Expect = 1.1
 Identities = 22/70 (31%), Positives = 35/70 (50%), Gaps = 3/70 (4%)

Query: 111 RDPVCMGPENTVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDIDFREGDPHLSLK 170
           R+P  +GP+  VAD +    + GF   PI       G+++G+ + RD   RE    +SL 
Sbjct: 79  RNPQSVGPDMRVADAVVIMIERGFRHLPIINT---AGKILGVFSIRDAMPREIGNAVSLA 135

Query: 171 EVMTPINDMI 180
           E    +ND +
Sbjct: 136 EFNDQVNDAL 145


>UniRef50_Q1Q2I4 Cluster: Putative uncharacterized protein; n=1;
           Candidatus Kuenenia stuttgartiensis|Rep: Putative
           uncharacterized protein - Candidatus Kuenenia
           stuttgartiensis
          Length = 133

 Score = 37.1 bits (82), Expect = 1.1
 Identities = 25/87 (28%), Positives = 42/87 (48%), Gaps = 11/87 (12%)

Query: 146 GGRLIGIVTSRDI----------DFREGDPHL-SLKEVMTPINDMITAQLGVTLQDANYI 194
           G  ++GI+T RD+          ++ E    L S+K       D+IT     +++DA  I
Sbjct: 35  GKEIVGILTQRDLYKASLTSIVTNWEENKTFLDSVKVAEVMTKDVITISPNTSIEDAAQI 94

Query: 195 LEKSKKGKLPIINNDGELVALIARTDL 221
           +   K G LP++ +   L+ LI  TD+
Sbjct: 95  MIDKKVGCLPVVEDKNTLLGLITETDV 121


>UniRef50_Q1LK44 Cluster: 2-nitropropane dioxygenase, NPD; n=2;
           Burkholderiaceae|Rep: 2-nitropropane dioxygenase, NPD -
           Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM
           2839)
          Length = 342

 Score = 37.1 bits (82), Expect = 1.1
 Identities = 24/71 (33%), Positives = 36/71 (50%)

Query: 312 VDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQSVGHIIKSL 371
           V A R+G+ + ++   +E    G  Q +A    A       +P++  GGI S   I  +L
Sbjct: 144 VTAQRLGVDAVALVGLEEGGHPGANQLSAFVNGAFALERVEIPLVIGGGIGSGRQIAAAL 203

Query: 372 ALGASTVMMGS 382
           ALGA  V+MGS
Sbjct: 204 ALGADGVVMGS 214


>UniRef50_A6CKR1 Cluster: Putative uncharacterized protein; n=1;
           Bacillus sp. SG-1|Rep: Putative uncharacterized protein
           - Bacillus sp. SG-1
          Length = 685

 Score = 37.1 bits (82), Expect = 1.1
 Identities = 16/55 (29%), Positives = 35/55 (63%), Gaps = 2/55 (3%)

Query: 167 LSLKEVMTPINDMITAQLGVTLQDANYILEKSKKGKLPIINNDGELVALIARTDL 221
           +  ++++TP++ M+T +   TL++A  I+++ K   LP+ +N G+L  +  R+ L
Sbjct: 2   IHFQDIVTPVDCMVTEE--TTLKEAVEIIKQKKWNLLPVTDNQGDLQGIFTRSGL 54


>UniRef50_A5UUL3 Cluster: Thiamine-phosphate pyrophosphorylase; n=3;
           Bacteria|Rep: Thiamine-phosphate pyrophosphorylase -
           Roseiflexus sp. RS-1
          Length = 236

 Score = 37.1 bits (82), Expect = 1.1
 Identities = 39/129 (30%), Positives = 64/129 (49%), Gaps = 15/129 (11%)

Query: 256 LLVNNGVDV-IVLDSSQ---GNSTYQIKMIKYIKETYPEIQVVGGNVVTRMQAKNLIDAG 311
           L+VN+ VDV + LD+     G      +M++ I    PE +++G +V T  QA+  +DAG
Sbjct: 86  LIVNDRVDVALALDADGVHVGQDDIPAEMVRRI--IGPE-RILGVSVATVEQAQRAMDAG 142

Query: 312 VDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFNVPVIADGGIQ--SVGHIIK 369
              + VG   G    T      G P    +  +A  AR  N+PV+  GGI   +   +I+
Sbjct: 143 ATYVSVGDLFG----TPSKPDAGPP--IGLEPLAEIARTVNLPVLGIGGINLANAASVIR 196

Query: 370 SLALGASTV 378
           + A+G + +
Sbjct: 197 AGAVGVAVI 205


>UniRef50_O27292 Cluster: Inosine-5'-monophosphate dehydrogenase
           related protein III; n=2; Methanobacteriaceae|Rep:
           Inosine-5'-monophosphate dehydrogenase related protein
           III - Methanobacterium thermoautotrophicum
          Length = 313

 Score = 37.1 bits (82), Expect = 1.1
 Identities = 34/117 (29%), Positives = 56/117 (47%), Gaps = 20/117 (17%)

Query: 121 TVADVLEAKKKNGFTGYPITQNGKLGGRLIGIVTSRDI-DFREGDPHLS----------L 169
           T+ +  E   KN F   PIT  G   G+L GIVT+ DI DF  G               L
Sbjct: 47  TIKEAAEIMVKNKFRRLPITNPGT--GKLQGIVTAMDILDFLGGGDKSKIIDKKYDDNFL 104

Query: 170 KEVMTPINDMITAQ-LGVTLQDA-----NYILEKSKKGKLPIINNDGELVALIARTD 220
             V  P+  ++T   + +T +D+     + +LE S  G LP++++D ++  +++  D
Sbjct: 105 AAVNEPVKSIMTRDVISITTRDSIADAVSMMLENSV-GALPVVDDDEKIAGIVSERD 160


>UniRef50_P61411 Cluster: Putative thiamine-phosphate
           pyrophosphorylase; n=8; Desulfuromonadales|Rep: Putative
           thiamine-phosphate pyrophosphorylase - Geobacter
           sulfurreducens
          Length = 213

 Score = 37.1 bits (82), Expect = 1.1
 Identities = 40/150 (26%), Positives = 70/150 (46%), Gaps = 8/150 (5%)

Query: 236 KQLLVGAAIGTRDTDRERLKLLVNNGVDVIVLDSSQGNSTYQIKMIKYI-KETYPEIQVV 294
           + LL  A    R TDR   +LL+N+ VD+ +   + G    +  M   + +E     +++
Sbjct: 47  RTLLELARAMRRLTDRFGARLLINDRVDIALAAGADGVHLGEEGMPAAVARELLGSGRLI 106

Query: 295 GGNVVTRMQAKNLIDAGVDALRVGMGSGSICITQEVMACGCPQATAVYQVASYARHFNVP 354
           G +   R  A   +  G D +      G +  T    A G P    + Q+A+  +  ++P
Sbjct: 107 GVSCHGRGGAAAAVAQGADFITF----GPVYPTPSKAAYGEP--VGIDQLAATTKEIHIP 160

Query: 355 VIADGGIQSVGHIIKSLALGASTVMMGSLL 384
           V A GGI+   +I ++LA GA+ V + S +
Sbjct: 161 VFALGGIKE-ANIPEALAAGAAGVALISAI 189


  Database: uniref50
    Posted date:  Oct 5, 2007 11:19 AM
  Number of letters in database: 575,637,011
  Number of sequences in database:  1,657,284
  
Lambda     K      H
   0.317    0.135    0.382 

Gapped
Lambda     K      H
   0.279   0.0580    0.190 


Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 554,303,674
Number of Sequences: 1657284
Number of extensions: 23354367
Number of successful extensions: 59824
Number of sequences better than 10.0: 398
Number of HSP's better than 10.0 without gapping: 146
Number of HSP's successfully gapped in prelim test: 252
Number of HSP's that attempted gapping in prelim test: 59317
Number of HSP's gapped (non-prelim): 569
length of query: 512
length of database: 575,637,011
effective HSP length: 104
effective length of query: 408
effective length of database: 403,279,475
effective search space: 164538025800
effective search space used: 164538025800
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.6 bits)
S2: 75 (34.3 bits)

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