Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001012-TA|BGIBMGA001012-PA|IPR011009|Protein
kinase-like, IPR000719|Protein kinase, IPR008271|Serine/threonine
protein kinase, active site, IPR001245|Tyrosine protein kinase,
IPR002290|Serine/threonine protein kinase
(655 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
BC022515-1|AAH22515.1| 367|Homo sapiens testis-specific serine ... 235 3e-61
AY028964-1|AAK27734.1| 367|Homo sapiens testis-specific serine/... 235 3e-61
AB284522-1|BAF41973.1| 367|Homo sapiens testis-specific serine ... 235 3e-61
CR456587-1|CAG30473.1| 358|Homo sapiens STK22A protein. 231 4e-60
BC037781-1|AAH37781.1| 358|Homo sapiens testis-specific serine ... 231 4e-60
AF362953-1|AAK98531.1| 358|Homo sapiens testis specific serine/... 231 4e-60
AB284523-1|BAF41974.1| 358|Homo sapiens testis-specific serine ... 231 4e-60
BC035354-1|AAH35354.1| 268|Homo sapiens testis-specific serine ... 212 3e-54
AY048701-1|AAL02128.1| 268|Homo sapiens TSSK3 protein. 212 3e-54
AL109945-4|CAI22888.1| 268|Homo sapiens testis-specific serine ... 212 3e-54
AF296450-1|AAK97141.1| 268|Homo sapiens testis-specific serine/... 212 3e-54
BC014611-1|AAH14611.1| 273|Homo sapiens testis-specific serine ... 204 6e-52
AF329483-1|AAK48827.1| 273|Homo sapiens serine/threonine protei... 204 6e-52
AY461663-1|AAS17971.1| 328|Homo sapiens testis-specific serine ... 196 3e-49
AK172841-1|BAD18805.1| 406|Homo sapiens protein ( Homo sapiens ... 194 8e-49
AK131042-1|BAC85482.1| 338|Homo sapiens protein ( Homo sapiens ... 184 9e-46
BC038504-1|AAH38504.1| 783|Homo sapiens SNF1-like kinase protein. 173 1e-42
AK131076-1|BAC85126.1| 764|Homo sapiens FLJ00263 protein protein. 173 1e-42
AB047786-1|BAD74070.1| 783|Homo sapiens serine/threonine protei... 173 1e-42
X97630-1|CAA66229.1| 745|Homo sapiens serine/threonine protein ... 173 2e-42
BT007342-1|AAP36006.1| 755|Homo sapiens MAP/microtubule affinit... 173 2e-42
BC084540-1|AAH84540.1| 724|Homo sapiens MAP/microtubule affinit... 173 2e-42
BC008771-1|AAH08771.2| 778|Homo sapiens MARK2 protein protein. 173 2e-42
AF387638-1|AAK82368.1| 691|Homo sapiens Ser/Thr protein kinase ... 173 2e-42
AB188493-1|BAD37141.1| 719|Homo sapiens serine/threonine kinase... 173 2e-42
U64205-1|AAC15093.1| 729|Homo sapiens Cdc25C associated protein... 172 4e-42
BC024773-1|AAH24773.1| 729|Homo sapiens MAP/microtubule affinit... 172 4e-42
AF387637-1|AAK82367.1| 744|Homo sapiens Ser/Thr protein kinase ... 172 4e-42
BC114478-1|AAI14479.1| 795|Homo sapiens MARK1 protein protein. 171 5e-42
BC113869-1|AAI13870.1| 795|Homo sapiens MARK1 protein protein. 171 5e-42
AL592406-3|CAH72463.1| 795|Homo sapiens MAP/microtubule affinit... 171 5e-42
AF154845-1|AAF72103.1| 795|Homo sapiens MARK protein. 171 5e-42
M80359-1|AAA59991.1| 713|Homo sapiens protein p78 protein. 171 9e-42
AY120867-1|AAM55491.1| 752|Homo sapiens MAP/microtubule affinit... 171 9e-42
AY057448-1|AAL23683.1| 752|Homo sapiens MARK4 serine/threonine ... 171 9e-42
AK075272-1|BAC11510.1| 752|Homo sapiens protein ( Homo sapiens ... 171 9e-42
AF465413-1|AAL69982.1| 753|Homo sapiens MAP/microtubule affinit... 171 9e-42
AB058763-1|BAB47489.1| 689|Homo sapiens KIAA1860 protein protein. 171 9e-42
BC017306-1|AAH17306.1| 628|Homo sapiens NUAK family, SNF1-like ... 169 3e-41
AK074830-1|BAC11234.1| 628|Homo sapiens protein ( Homo sapiens ... 169 3e-41
BC128510-1|AAI28511.1| 1203|Homo sapiens KIAA0999 protein protein. 169 4e-41
AB088047-1|BAC03375.1| 752|Homo sapiens microtubule affinity-re... 169 4e-41
AB049127-1|BAB39380.1| 688|Homo sapiens MAP/microtubule affinit... 169 4e-41
AB023216-1|BAA76843.2| 1371|Homo sapiens KIAA0999 protein protein. 169 4e-41
AP001751-1|BAA95536.1| 786|Homo sapiens SNF1LK protein. 167 8e-41
EF056019-1|ABK30810.1| 552|Homo sapiens AMP-activated alpha 2 s... 163 2e-39
BC069823-1|AAH69823.1| 552|Homo sapiens AMP-activated protein k... 163 2e-39
BC069740-1|AAH69740.1| 552|Homo sapiens AMP-activated protein k... 163 2e-39
BC069680-1|AAH69680.1| 552|Homo sapiens protein kinase, AMP-act... 163 2e-39
AL035705-2|CAC17574.2| 552|Homo sapiens protein kinase, AMP-act... 163 2e-39
U06454-1|AAA64745.1| 552|Homo sapiens AMP-activated protein kin... 159 2e-38
BC117183-1|AAI17184.1| 926|Homo sapiens SNF1-like kinase 2 prot... 159 2e-38
BC113459-1|AAI13460.1| 926|Homo sapiens SNF1-like kinase 2 prot... 159 2e-38
AB084424-1|BAB91442.1| 346|Homo sapiens KIAA0781 protein protein. 159 2e-38
AB018324-1|BAA34501.3| 950|Homo sapiens KIAA0781 protein protein. 159 2e-38
AB022017-1|BAA36547.1| 550|Homo sapiens AMP-activated protein k... 159 4e-38
BC037303-1|AAH37303.1| 550|Homo sapiens PRKAA1 protein protein. 157 9e-38
AB011109-1|BAA25463.2| 698|Homo sapiens KIAA0537 protein protein. 157 9e-38
AY505124-1|AAS86442.1| 778|Homo sapiens protein kinase SAD-B pr... 156 2e-37
AY458602-1|AAS10354.1| 778|Homo sapiens SAD1 kinase protein. 156 2e-37
AF479827-1|AAL87698.1| 778|Homo sapiens protein kinase-like pro... 156 2e-37
AF479826-1|AAL87697.1| 794|Homo sapiens putative serine/threoni... 156 2e-37
D79997-1|BAA11492.2| 656|Homo sapiens KIAA0175 protein. 154 1e-36
BC014039-1|AAH14039.1| 651|Homo sapiens maternal embryonic leuc... 153 1e-36
AL442063-1|CAI16995.2| 651|Homo sapiens maternal embryonic leuc... 153 1e-36
AL354932-1|CAI11034.2| 651|Homo sapiens maternal embryonic leuc... 153 1e-36
AK222811-1|BAD96531.1| 651|Homo sapiens maternal embryonic leuc... 153 1e-36
AY505125-1|AAS86443.1| 696|Homo sapiens protein kinase SAD-A pr... 153 2e-36
BC111088-1|AAI11089.1| 252|Homo sapiens TSSK4 protein protein. 153 2e-36
AK131534-1|BAD18671.1| 766|Homo sapiens protein ( Homo sapiens ... 152 4e-36
AY166857-1|AAN87839.1| 668|Homo sapiens serine/threonine protei... 151 6e-36
AF533880-1|AAP97727.1| 674|Homo sapiens putative serine/threoni... 151 6e-36
AF533879-1|AAP97726.1| 736|Homo sapiens putative serine/threoni... 151 6e-36
AF533878-1|AAP97725.1| 674|Homo sapiens putative serine/threoni... 151 6e-36
AF533877-1|AAP97724.1| 674|Homo sapiens putative serine/threoni... 151 6e-36
AF533876-1|AAP97723.1| 668|Homo sapiens putative serine/threoni... 151 6e-36
AB058714-1|BAB47440.1| 715|Homo sapiens KIAA1811 protein protein. 151 1e-35
AF159295-1|AAD48007.1| 752|Homo sapiens serine/threonine protei... 150 2e-35
BC031231-1|AAH31231.1| 514|Homo sapiens serine/threonine kinase... 149 2e-35
AK093251-1|BAC04109.1| 514|Homo sapiens protein ( Homo sapiens ... 149 2e-35
AJ303380-1|CAC29064.1| 514|Homo sapiens serine/threonine kinase... 149 2e-35
AJ271722-1|CAB71146.1| 714|Homo sapiens putative serine/threoni... 148 5e-35
BC032787-1|AAH32787.1| 476|Homo sapiens calcium/calmodulin-depe... 148 7e-35
AY212935-1|AAP29964.1| 460|Homo sapiens CLICK III protein. 148 7e-35
AL049688-1|CAB41259.1| 481|Homo sapiens hypothetical protein pr... 148 7e-35
AL023754-3|CAI19991.1| 476|Homo sapiens calcium/calmodulin-depe... 148 7e-35
AF428261-1|AAL28100.1| 476|Homo sapiens calcium/calmodulin-depe... 148 7e-35
L41816-1|AAA99458.1| 370|Homo sapiens cam kinase I protein. 146 2e-34
BC106755-1|AAI06756.1| 370|Homo sapiens calcium/calmodulin-depe... 146 2e-34
BC106754-1|AAI06755.1| 370|Homo sapiens calcium/calmodulin-depe... 146 2e-34
BC036422-1|AAH36422.1| 436|Homo sapiens hypothetical protein MG... 143 2e-33
BC048980-1|AAH48980.1| 574|Homo sapiens protein kinase, AMP-act... 142 4e-33
BC062616-1|AAH62616.1| 424|Homo sapiens protein serine kinase H... 140 1e-32
AL592406-2|CAH72462.1| 758|Homo sapiens MAP/microtubule affinit... 140 1e-32
AJ272212-1|CAB91984.1| 424|Homo sapiens protein serine kinase p... 140 1e-32
AB040910-1|BAA96001.1| 870|Homo sapiens KIAA1477 protein protein. 140 1e-32
AK027493-1|BAB55152.1| 638|Homo sapiens protein ( Homo sapiens ... 140 2e-32
AK074578-1|BAC11070.1| 426|Homo sapiens protein ( Homo sapiens ... 139 2e-32
BC035745-1|AAH35745.1| 385|Homo sapiens calcium/calmodulin-depe... 139 3e-32
AL731559-2|CAI14675.1| 385|Homo sapiens calcium/calmodulin-depe... 139 3e-32
AL731559-1|CAI14674.1| 357|Homo sapiens calcium/calmodulin-depe... 139 3e-32
AL512783-2|CAH74036.1| 385|Homo sapiens calcium/calmodulin-depe... 139 3e-32
AL512783-1|CAH74035.1| 357|Homo sapiens calcium/calmodulin-depe... 139 3e-32
AL512284-2|CAH71694.1| 385|Homo sapiens calcium/calmodulin-depe... 139 3e-32
AL512284-1|CAH71693.1| 357|Homo sapiens calcium/calmodulin-depe... 139 3e-32
AL391314-2|CAI14410.1| 385|Homo sapiens calcium/calmodulin-depe... 139 3e-32
AL391314-1|CAI14409.1| 357|Homo sapiens calcium/calmodulin-depe... 139 3e-32
AJ006701-1|CAA07196.1| 603|Homo sapiens putative serine/threoni... 139 3e-32
AF286366-1|AAG00534.1| 357|Homo sapiens CamKI-like protein kina... 139 3e-32
AB081726-1|BAC19846.1| 385|Homo sapiens CaM-kinase I delta prot... 139 3e-32
D43636-1|BAA07744.2| 766|Homo sapiens KIAA0096 protein. 137 1e-31
Y15056-1|CAA75341.1| 556|Homo sapiens PkB kinase protein. 136 2e-31
U08316-1|AAA81952.1| 740|Homo sapiens insulin-stimulated protei... 136 2e-31
L07599-1|AAC82495.1| 580|Homo sapiens ribosomal protein S6 kina... 136 2e-31
CR536566-1|CAG38803.1| 745|Homo sapiens RPS6KA6 protein. 136 2e-31
CR536517-1|CAG38755.1| 556|Homo sapiens PDPK1 protein. 136 2e-31
BC096302-1|AAH96302.1| 740|Homo sapiens ribosomal protein S6 ki... 136 2e-31
BC096301-1|AAH96301.1| 740|Homo sapiens ribosomal protein S6 ki... 136 2e-31
BC012103-1|AAH12103.1| 556|Homo sapiens 3-phosphoinositide depe... 136 2e-31
AL807772-3|CAI39687.1| 740|Homo sapiens ribosomal protein S6 ki... 136 2e-31
AL732366-2|CAI40548.1| 740|Homo sapiens ribosomal protein S6 ki... 136 2e-31
AF017995-1|AAC51825.1| 556|Homo sapiens 3-phosphoinositide depe... 136 2e-31
AC005591-1|AAC33797.1| 367|Homo sapiens PkB-like protein. 136 2e-31
AB209835-1|BAD93072.1| 492|Homo sapiens 3-phosphoinositide depe... 136 2e-31
AB208933-1|BAD92170.1| 806|Homo sapiens ribosomal protein S6 ki... 136 2e-31
AB102662-1|BAC81131.1| 726|Homo sapiens RPS6KA3 protein. 136 2e-31
AL389887-1|CAC16111.2| 745|Homo sapiens ribosomal protein S6 ki... 136 3e-31
AL354653-1|CAD13486.2| 745|Homo sapiens ribosomal protein S6 ki... 136 3e-31
AF184965-1|AAF13190.1| 745|Homo sapiens ribosomal S6 kinase pro... 136 3e-31
AJ785968-1|CAH05056.1| 396|Homo sapiens PDPK2 protein protein. 135 4e-31
AC005581-1|AAC33487.1| 462|Homo sapiens R31237_1, partial CDS p... 135 4e-31
Z98049-1|CAI20579.1| 733|Homo sapiens ribosomal protein S6 kina... 135 5e-31
X85106-1|CAA59427.1| 733|Homo sapiens ribosomal S6 kinase protein. 135 5e-31
L33881-1|AAB17011.1| 587|Homo sapiens protein kinase C iota pro... 135 5e-31
L18964-1|AAA60171.1| 587|Homo sapiens protein kinase C iota pro... 135 5e-31
L07597-1|AAC82497.1| 735|Homo sapiens ribosomal protein S6 kina... 135 5e-31
BC014966-1|AAH14966.1| 735|Homo sapiens ribosomal protein S6 ki... 135 5e-31
BC002363-1|AAH02363.1| 733|Homo sapiens ribosomal protein S6 ki... 135 5e-31
AL627313-6|CAI14649.1| 735|Homo sapiens ribosomal protein S6 ki... 135 5e-31
AL022069-2|CAI19651.1| 733|Homo sapiens ribosomal protein S6 ki... 135 5e-31
AF226044-1|AAF86944.1| 765|Homo sapiens HSNFRK protein. 135 5e-31
AB209116-1|BAD92353.1| 806|Homo sapiens ribosomal protein S6 ki... 135 5e-31
BC071567-1|AAH71567.1| 765|Homo sapiens SNRK protein protein. 134 7e-31
BC096303-1|AAH96303.1| 740|Homo sapiens ribosomal protein S6 ki... 134 9e-31
BC022016-1|AAH22016.3| 587|Homo sapiens protein kinase C, iota ... 134 9e-31
AK222581-1|BAD96301.1| 556|Homo sapiens 3-phosphoinositide depe... 134 9e-31
L07598-1|AAC82496.1| 540|Homo sapiens ribosomal protein S6 kina... 134 1e-30
Z84486-1|CAI21678.1| 526|Homo sapiens serum/glucocorticoid regu... 132 3e-30
Y10032-1|CAA71138.1| 431|Homo sapiens serine/threonine protein ... 132 3e-30
BC001263-1|AAH01263.1| 431|Homo sapiens serum/glucocorticoid re... 132 3e-30
AL355881-2|CAH72579.1| 526|Homo sapiens serum/glucocorticoid re... 132 3e-30
AL135839-4|CAI19721.1| 526|Homo sapiens serum/glucocorticoid re... 132 3e-30
AL135839-3|CAI19720.1| 445|Homo sapiens serum/glucocorticoid re... 132 3e-30
AL135839-2|CAI19719.1| 431|Homo sapiens serum/glucocorticoid re... 132 3e-30
AL135839-1|CAI19718.1| 421|Homo sapiens serum/glucocorticoid re... 132 3e-30
AJ000512-1|CAA04146.1| 431|Homo sapiens serine/threonine protei... 132 3e-30
AF153609-1|AAD41091.1| 431|Homo sapiens serine/threonine protei... 132 3e-30
BC017187-1|AAH17187.1| 549|Homo sapiens ribosomal protein S6 ki... 130 1e-29
AF090421-1|AAC69577.1| 809|Homo sapiens ribosome S6 protein kin... 130 1e-29
AF080000-1|AAD23915.1| 802|Homo sapiens RSK-like protein kinase... 130 1e-29
AF074393-1|AAC31171.1| 802|Homo sapiens nuclear mitogen- and st... 130 1e-29
L24959-1|AAA18251.1| 473|Homo sapiens calcium/calmodulin depend... 130 2e-29
L17000-1|AAA35639.1| 473|Homo sapiens calcium/calmodulin-depend... 130 2e-29
D30742-1|BAA06403.1| 473|Homo sapiens calmodulin-dependent prot... 130 2e-29
BC126182-1|AAI26183.1| 385|Homo sapiens protein serine kinase H... 130 2e-29
BC126180-1|AAI26181.1| 385|Homo sapiens protein serine kinase H... 130 2e-29
BC063885-1|AAH63885.1| 708|Homo sapiens NIMA (never in mitosis ... 130 2e-29
BC025687-1|AAH25687.1| 473|Homo sapiens calcium/calmodulin-depe... 130 2e-29
BC016695-1|AAH16695.2| 503|Homo sapiens CAMK4 protein protein. 130 2e-29
AY037806-1|AAK59985.1| 385|Homo sapiens serine/threonine kinase... 130 2e-29
AL139082-5|CAI12892.2| 708|Homo sapiens NIMA (never in mitosis ... 130 2e-29
CR456418-1|CAG30304.1| 586|Homo sapiens CHEK2 protein. 130 2e-29
BC004207-1|AAH04207.1| 543|Homo sapiens CHK2 checkpoint homolog... 130 2e-29
AY800241-1|AAV41895.1| 543|Homo sapiens CHK2 checkpoint homolog... 130 2e-29
AY551303-1|AAS58464.1| 452|Homo sapiens protein kinase Chk2 tra... 130 2e-29
AY551297-1|AAS58458.1| 586|Homo sapiens protein kinase Chk2 tra... 130 2e-29
AL121825-1|CAH73823.1| 543|Homo sapiens CHK2 checkpoint homolog... 130 2e-29
AL117330-1|CAH73875.1| 543|Homo sapiens CHK2 checkpoint homolog... 130 2e-29
AJ131197-1|CAA10319.1| 543|Homo sapiens protein kinase protein. 130 2e-29
AF174135-1|AAD48504.1| 543|Homo sapiens protein kinase CHK2 pro... 130 2e-29
AF096279-1|AAD11784.1| 543|Homo sapiens HuCds1 kinase protein. 130 2e-29
AF086904-1|AAC83693.1| 543|Homo sapiens protein kinase Chk2 pro... 130 2e-29
AF217975-1|AAG17218.1| 322|Homo sapiens unknown protein. 129 3e-29
U66064-1|AAB80848.1| 315|Homo sapiens calcium/calmodulin-depend... 128 5e-29
AL713896-5|CAI13788.1| 516|Homo sapiens calcium/calmodulin-depe... 128 5e-29
AL713896-4|CAI13789.1| 495|Homo sapiens calcium/calmodulin-depe... 128 5e-29
AL713896-3|CAI13790.1| 529|Homo sapiens calcium/calmodulin-depe... 128 5e-29
AL713896-2|CAI13791.1| 527|Homo sapiens calcium/calmodulin-depe... 128 5e-29
AL596247-5|CAI13967.1| 516|Homo sapiens calcium/calmodulin-depe... 128 5e-29
AL596247-4|CAI13966.1| 495|Homo sapiens calcium/calmodulin-depe... 128 5e-29
AL596247-3|CAI13965.1| 529|Homo sapiens calcium/calmodulin-depe... 128 5e-29
AL596247-2|CAI13968.1| 527|Homo sapiens calcium/calmodulin-depe... 128 5e-29
BC047896-1|AAH47896.1| 524|Homo sapiens RPS6KA4 protein protein. 128 6e-29
BC034044-1|AAH34044.1| 527|Homo sapiens calcium/calmodulin-depe... 128 6e-29
BC028079-1|AAH28079.1| 556|Homo sapiens Unknown (protein for IM... 128 6e-29
AK223561-1|BAD97281.1| 765|Homo sapiens ribosomal protein S6 ki... 128 6e-29
AJ010119-1|CAA09009.1| 772|Homo sapiens Ribosomal protein kinas... 128 6e-29
BC027464-1|AAH27464.1| 403|Homo sapiens aurora kinase A protein. 128 8e-29
BC006423-1|AAH06423.1| 403|Homo sapiens aurora kinase A protein. 128 8e-29
BC002499-1|AAH02499.1| 403|Homo sapiens AURKA protein protein. 128 8e-29
BC001280-1|AAH01280.1| 403|Homo sapiens aurora kinase A protein. 128 8e-29
AL121914-3|CAC12717.1| 403|Homo sapiens aurora kinase A protein. 128 8e-29
AF195947-1|AAF29508.1| 403|Homo sapiens STK15 serine/threonine ... 128 8e-29
AF074715-1|AAC67395.1| 705|Homo sapiens mitogen- and stress-act... 128 8e-29
AF011468-1|AAC63902.1| 403|Homo sapiens serine/threonine kinase... 128 8e-29
AF008551-1|AAC12708.1| 403|Homo sapiens aurora-related kinase 1... 128 8e-29
Z15108-1|CAA78813.1| 584|Homo sapiens protein kinase C zeta pro... 127 1e-28
BT007082-1|AAP35745.1| 592|Homo sapiens protein kinase C, zeta ... 127 1e-28
BC014270-1|AAH14270.1| 592|Homo sapiens protein kinase C, zeta ... 127 1e-28
BC008058-1|AAH08058.1| 592|Homo sapiens protein kinase C, zeta ... 127 1e-28
AL645703-1|CAI21535.1| 592|Homo sapiens protein kinase C, zeta ... 127 1e-28
AL590822-6|CAI12484.1| 592|Homo sapiens protein kinase C, zeta ... 127 1e-28
AL391845-5|CAI15438.1| 592|Homo sapiens protein kinase C, zeta ... 127 1e-28
L14283-1|AAA36488.1| 592|Homo sapiens protein kinase C zeta pro... 127 1e-28
BC128511-1|AAI28512.1| 1102|Homo sapiens KIAA0999 protein protein. 127 1e-28
AF145711-1|AAD30559.1| 489|Homo sapiens calcium/calmodulin-depe... 125 4e-28
AF145710-1|AAD30558.1| 478|Homo sapiens calcium/calmodulin-depe... 125 4e-28
AF091486-1|AAD55815.1| 478|Homo sapiens calmodulin-dependent pr... 125 4e-28
AB023185-1|BAA76812.1| 527|Homo sapiens KIAA0968 protein protein. 125 4e-28
M34181-1|AAA60170.1| 351|Homo sapiens cAMP-dependent protein ki... 125 6e-28
DQ667174-1|ABG25919.1| 398|Homo sapiens protein kinase, cAMP-de... 125 6e-28
BC040457-1|AAH40457.1| 478|Homo sapiens calcium/calmodulin-depe... 125 6e-28
AY633609-1|AAV33302.1| 672|Homo sapiens aging-associated gene 6... 125 6e-28
AL450063-3|CAI16846.1| 398|Homo sapiens protein kinase, cAMP-de... 125 6e-28
AL450063-2|CAI16845.1| 351|Homo sapiens protein kinase, cAMP-de... 125 6e-28
AL359504-2|CAI14541.1| 351|Homo sapiens protein kinase, cAMP-de... 125 6e-28
AB209189-1|BAD92426.1| 365|Homo sapiens cAMP-dependent protein ... 125 6e-28
X52479-1|CAA36718.1| 672|Homo sapiens protein ( Human PKC alpha... 124 8e-28
BC109274-1|AAI09275.1| 672|Homo sapiens protein kinase C, alpha... 124 8e-28
BC109273-1|AAI09274.1| 672|Homo sapiens protein kinase C, alpha... 124 8e-28
BC036023-1|AAH36023.1| 970|Homo sapiens polo-like kinase 4 (Dro... 124 1e-27
AK000231-1|BAA91023.1| 244|Homo sapiens protein ( Homo sapiens ... 124 1e-27
D84212-1|BAA23592.1| 402|Homo sapiens aurora/IPL1-related kinas... 123 2e-27
BC022558-1|AAH22558.1| 344|Homo sapiens CAMK2D protein protein. 123 2e-27
AB006972-1|BAB69958.1| 970|Homo sapiens Sak protein. 123 2e-27
Y13115-1|CAA73575.1| 970|Homo sapiens serine/threonine protein ... 123 2e-27
BT020098-1|AAV38901.1| 367|Homo sapiens serum/glucocorticoid re... 123 2e-27
BC035058-1|AAH35058.1| 351|Homo sapiens protein kinase, cAMP-de... 123 2e-27
AF415197-1|AAM33514.1| 566|Homo sapiens calcium/calmodulin-depe... 123 2e-27
X07767-1|CAA30597.1| 351|Homo sapiens protein ( Human mRNA for ... 122 3e-27
DQ667173-1|ABG25918.1| 351|Homo sapiens protein kinase, cAMP-de... 122 3e-27
BC108259-1|AAI08260.1| 351|Homo sapiens protein kinase, cAMP-de... 122 3e-27
BC075064-1|AAH75064.2| 275|Homo sapiens AURKC protein protein. 122 3e-27
BC039846-1|AAH39846.1| 351|Homo sapiens protein kinase, cAMP-de... 122 3e-27
AY714054-1|AAU04399.1| 306|Homo sapiens aurora-C protein. 122 3e-27
AY661554-1|AAT64422.1| 290|Homo sapiens aurora/Ipl1-related kin... 122 3e-27
AB017332-1|BAA76292.1| 309|Homo sapiens Aurora/Ipl1-related kin... 122 3e-27
Z98752-7|CAC18509.1| 367|Homo sapiens serum/glucocorticoid regu... 122 4e-27
Z98752-5|CAI42312.1| 427|Homo sapiens serum/glucocorticoid regu... 122 4e-27
BC065511-1|AAH65511.1| 367|Homo sapiens SGK2 protein protein. 122 4e-27
BC014037-1|AAH14037.3| 367|Homo sapiens serum/glucocorticoid re... 122 4e-27
AF186470-1|AAG17012.1| 427|Homo sapiens protein kinase protein. 122 4e-27
AF169034-1|AAF12757.2| 367|Homo sapiens protein kinase protein. 122 4e-27
AL807772-1|CAI39684.1| 227|Homo sapiens ribosomal protein S6 ki... 122 5e-27
AF054621-1|AAC25955.1| 309|Homo sapiens serine/threonine kinase... 122 5e-27
Z98752-8|CAI42315.1| 366|Homo sapiens serum/glucocorticoid regu... 121 7e-27
BC019916-1|AAH19916.2| 506|Homo sapiens NIMA (never in mitosis ... 121 7e-27
AL139082-7|CAI12895.1| 507|Homo sapiens NIMA (never in mitosis ... 121 7e-27
AK131359-1|BAD18511.1| 510|Homo sapiens protein ( Homo sapiens ... 121 7e-27
BC020479-1|AAH20479.1| 466|Homo sapiens AKT3 protein protein. 121 9e-27
BC013300-1|AAH13300.2| 371|Homo sapiens AURKB protein protein. 121 9e-27
BC009751-1|AAH09751.1| 344|Homo sapiens aurora kinase B protein. 121 9e-27
AY005799-1|AAF91073.1| 465|Homo sapiens protein kinase B gamma ... 121 9e-27
AL662889-3|CAH73073.1| 479|Homo sapiens v-akt murine thymoma vi... 121 9e-27
AL662889-2|CAH73072.1| 465|Homo sapiens v-akt murine thymoma vi... 121 9e-27
AL592151-2|CAH72892.1| 479|Homo sapiens v-akt murine thymoma vi... 121 9e-27
AL592151-1|CAH72891.1| 465|Homo sapiens v-akt murine thymoma vi... 121 9e-27
AL591721-2|CAH71867.1| 479|Homo sapiens v-akt murine thymoma vi... 121 9e-27
AL591721-1|CAH71866.1| 465|Homo sapiens v-akt murine thymoma vi... 121 9e-27
AJ245709-1|CAB53537.1| 479|Homo sapiens Akt-3 protein protein. 121 9e-27
AF135794-1|AAD24196.1| 479|Homo sapiens AKT3 protein kinase pro... 121 9e-27
AF124141-1|AAD29089.1| 479|Homo sapiens protein kinase B gamma ... 121 9e-27
AF085234-1|AAL40392.1| 479|Homo sapiens STK-2 protein. 121 9e-27
U22456-1|AAA64850.1| 174|Homo sapiens AMP-activated protein kin... 120 1e-26
BT019534-1|AAV38341.1| 344|Homo sapiens serine/threonine kinase... 120 1e-26
BC080581-1|AAH80581.1| 344|Homo sapiens aurora kinase B protein. 120 1e-26
BC032784-1|AAH32784.1| 478|Homo sapiens calcium/calmodulin-depe... 120 1e-26
BC000442-1|AAH00442.3| 344|Homo sapiens aurora kinase B protein. 120 1e-26
AY987010-1|AAX88805.1| 393|Homo sapiens serum/glucocorticoid re... 120 1e-26
AL627402-5|CAH71238.1| 897|Homo sapiens calcium/calmodulin-depe... 120 1e-26
AL603754-3|CAI41637.1| 897|Homo sapiens calcium/calmodulin-depe... 120 1e-26
AL445239-4|CAI41095.1| 897|Homo sapiens calcium/calmodulin-depe... 120 1e-26
AL353691-4|CAI42247.1| 897|Homo sapiens calcium/calmodulin-depe... 120 1e-26
AL158144-2|CAI42765.1| 897|Homo sapiens calcium/calmodulin-depe... 120 1e-26
AF071569-1|AAD20442.1| 499|Homo sapiens multifunctional calcium... 120 1e-26
AF035582-1|AAB88198.1| 897|Homo sapiens CASK protein. 120 1e-26
AF008552-1|AAC12709.1| 344|Homo sapiens aurora-related kinase 2... 120 1e-26
AB209288-1|BAD92525.1| 522|Homo sapiens calcium/calmodulin-depe... 120 1e-26
AB011450-1|BAA32136.1| 344|Homo sapiens aurora and IPL1-like mi... 120 1e-26
CR536581-1|CAG38818.1| 429|Homo sapiens SGKL protein. 120 2e-26
BC117311-1|AAI17312.1| 898|Homo sapiens CASK protein protein. 120 2e-26
BC015326-1|AAH15326.1| 496|Homo sapiens serum/glucocorticoid re... 120 2e-26
AY705392-1|AAU10527.1| 921|Homo sapiens calcium/calmodulin-depe... 120 2e-26
AL627402-6|CAH71241.1| 590|Homo sapiens calcium/calmodulin-depe... 120 2e-26
AL627402-4|CAH71237.1| 909|Homo sapiens calcium/calmodulin-depe... 120 2e-26
AL627402-3|CAH71240.1| 926|Homo sapiens calcium/calmodulin-depe... 120 2e-26
AL627402-2|CAH71239.1| 921|Homo sapiens calcium/calmodulin-depe... 120 2e-26
AL603754-6|CAI41638.1| 590|Homo sapiens calcium/calmodulin-depe... 120 2e-26
AL603754-5|CAI41635.1| 926|Homo sapiens calcium/calmodulin-depe... 120 2e-26
AL603754-4|CAI41636.1| 921|Homo sapiens calcium/calmodulin-depe... 120 2e-26
AL603754-2|CAI41634.1| 909|Homo sapiens calcium/calmodulin-depe... 120 2e-26
AL445239-7|CAI41096.1| 590|Homo sapiens calcium/calmodulin-depe... 120 2e-26
AL445239-6|CAI41093.1| 926|Homo sapiens calcium/calmodulin-depe... 120 2e-26
AL445239-5|CAI41094.1| 921|Homo sapiens calcium/calmodulin-depe... 120 2e-26
AL445239-3|CAI41092.1| 909|Homo sapiens calcium/calmodulin-depe... 120 2e-26
AL353691-7|CAI42248.1| 590|Homo sapiens calcium/calmodulin-depe... 120 2e-26
AL353691-6|CAI42245.1| 926|Homo sapiens calcium/calmodulin-depe... 120 2e-26
AL353691-5|CAI42246.1| 921|Homo sapiens calcium/calmodulin-depe... 120 2e-26
AL353691-3|CAI42244.1| 909|Homo sapiens calcium/calmodulin-depe... 120 2e-26
AL158144-5|CAI42766.1| 590|Homo sapiens calcium/calmodulin-depe... 120 2e-26
AL158144-4|CAI42763.1| 926|Homo sapiens calcium/calmodulin-depe... 120 2e-26
AL158144-3|CAI42764.1| 921|Homo sapiens calcium/calmodulin-depe... 120 2e-26
AL158144-1|CAI42762.1| 909|Homo sapiens calcium/calmodulin-depe... 120 2e-26
AK223523-1|BAD97243.1| 496|Homo sapiens serum/glucocorticoid re... 120 2e-26
AF169035-1|AAF12758.1| 429|Homo sapiens protein kinase protein. 120 2e-26
AF085233-1|AAF27051.2| 496|Homo sapiens SGK-like protein SGKL p... 120 2e-26
AF059681-1|AAC77369.1| 275|Homo sapiens serine/threonine kinase... 120 2e-26
AF032119-1|AAB88125.1| 921|Homo sapiens hCASK protein. 120 2e-26
AB072828-1|BAC15599.1| 489|Homo sapiens NIMA-related protein ki... 120 2e-26
DQ667175-1|ABG25920.1| 351|Homo sapiens protein kinase, cAMP-de... 120 2e-26
BC039888-1|AAH39888.1| 351|Homo sapiens protein kinase, cAMP-de... 120 2e-26
AL162730-1|CAH71828.1| 351|Homo sapiens protein kinase, cAMP-de... 120 2e-26
AJ001597-1|CAA04863.1| 351|Homo sapiens cAMP-dependent protein ... 120 2e-26
X73458-1|CAA51837.1| 603|Homo sapiens protein kinase protein. 119 3e-26
U23460-1|AAC99802.1| 664|Homo sapiens proline rich calmodulin-d... 119 3e-26
M34182-1|AAC41690.1| 360|Homo sapiens protein kinase A gamma-su... 119 3e-26
BC019070-1|AAH19070.1| 503|Homo sapiens calcium/calmodulin-depe... 119 3e-26
BC014846-1|AAH14846.1| 603|Homo sapiens polo-like kinase 1 (Dro... 119 3e-26
BC003002-1|AAH03002.1| 603|Homo sapiens polo-like kinase 1 (Dro... 119 3e-26
BC002369-1|AAH02369.1| 603|Homo sapiens polo-like kinase 1 (Dro... 119 3e-26
AJ252238-1|CAB65122.1| 518|Homo sapiens calcium/calmodulin depe... 119 3e-26
AJ252237-1|CAB65121.1| 479|Homo sapiens calcium/calmodulin depe... 119 3e-26
AJ252236-1|CAB65120.1| 503|Homo sapiens calcium/calmodulin depe... 119 3e-26
AF140350-1|AAD42070.1| 449|Homo sapiens calcium/calmodulin-depe... 119 3e-26
AF083419-1|AAD42038.1| 517|Homo sapiens calcium/calmodulin-depe... 119 3e-26
AF081924-1|AAD42037.1| 492|Homo sapiens calcium/calmodulin-depe... 119 3e-26
AF081572-1|AAD42036.1| 503|Homo sapiens calcium/calmodulin-depe... 119 3e-26
AF078803-1|AAD42035.1| 542|Homo sapiens calcium/calmodulin-depe... 119 3e-26
Z15114-1|CAA78820.1| 536|Homo sapiens protein kinase C gamma pr... 119 4e-26
X75932-1|CAA53536.1| 603|Homo sapiens Serine/Threonine protein ... 119 4e-26
U01038-1|AAA56634.1| 603|Homo sapiens pLK protein. 119 4e-26
M95936-1|AAA58364.1| 481|Homo sapiens protein serine/threonine ... 119 4e-26
M77198-1|AAA36585.1| 520|Homo sapiens rac protein kinase-beta p... 119 4e-26
BC120994-1|AAI20995.1| 481|Homo sapiens v-akt murine thymoma vi... 119 4e-26
BC047876-1|AAH47876.1| 697|Homo sapiens protein kinase C, gamma... 119 4e-26
BC006106-1|AAH06106.3| 482|Homo sapiens ribosomal protein S6 ki... 119 4e-26
BC000094-1|AAH00094.3| 482|Homo sapiens ribosomal protein S6 ki... 119 4e-26
AF345987-1|AAK13533.1| 697|Homo sapiens protein kinase C gamma ... 119 4e-26
AF112472-1|AAD03744.1| 542|Homo sapiens calcium/calmodulin-depe... 119 4e-26
AF112471-1|AAD03743.1| 517|Homo sapiens calcium/calmodulin-depe... 119 4e-26
AF099739-1|AAD20990.1| 482|Homo sapiens S6 kinase-related kinas... 119 4e-26
AF076931-1|AAD46063.1| 482|Homo sapiens serine/threonine kinase... 119 4e-26
AB067488-1|BAB67794.1| 1265|Homo sapiens KIAA1901 protein protein. 119 4e-26
AB019245-1|BAA37145.1| 481|Homo sapiens S6 kinase b protein. 119 4e-26
AB016869-1|BAA34402.1| 495|Homo sapiens p70 ribosomal S6 kinase... 119 4e-26
X80590-1|CAA56681.1| 387|Homo sapiens phosphorylase kinase prot... 118 5e-26
X07109-1|CAA30130.1| 673|Homo sapiens protein ( Human mRNA for ... 118 5e-26
X06318-1|CAA29634.1| 671|Homo sapiens protein ( Human mRNA for ... 118 5e-26
M13975-1|AAA60095.1| 673|Homo sapiens protein kinase C beta-II ... 118 5e-26
BC121154-1|AAI21155.1| 465|Homo sapiens v-akt murine thymoma vi... 118 5e-26
BC074753-1|AAH74753.1| 387|Homo sapiens phosphorylase kinase, g... 118 5e-26
BC069754-1|AAH69754.1| 387|Homo sapiens phosphorylase kinase, g... 118 5e-26
BC069738-1|AAH69738.1| 387|Homo sapiens phosphorylase kinase, g... 118 5e-26
BC069679-1|AAH69679.1| 387|Homo sapiens phosphorylase kinase, g... 118 5e-26
BC051327-1|AAH51327.1| 387|Homo sapiens phosphorylase kinase, g... 118 5e-26
BC036472-1|AAH36472.1| 673|Homo sapiens protein kinase C, beta ... 118 5e-26
AY987011-1|AAX88806.1| 489|Homo sapiens calcium/calmodulin-depe... 118 5e-26
AL834498-1|CAD39156.1| 716|Homo sapiens hypothetical protein pr... 118 5e-26
AF254253-1|AAL36972.1| 387|Homo sapiens phosphorylase kinase ga... 118 5e-26
AC093748-1|AAY40983.1| 443|Homo sapiens unknown protein. 118 5e-26
AC092101-3|AAS07453.1| 387|Homo sapiens unknown protein. 118 5e-26
AC002299-2|AAB97934.1| 496|Homo sapiens Protein kinase C beta (... 118 5e-26
AC002299-1|AAB97933.1| 494|Homo sapiens Protein kinase C beta (... 118 5e-26
AB209181-1|BAD92418.1| 796|Homo sapiens Hypothetical protein DK... 118 5e-26
AB051552-1|BAB21856.1| 608|Homo sapiens KIAA1765 protein protein. 118 5e-26
L19559-1|AAA36659.1| 603|Homo sapiens protein kinase protein. 118 7e-26
BC114491-1|AAI14492.1| 1189|Homo sapiens NEK1 protein protein. 118 7e-26
BC015147-1|AAH15147.1| 403|Homo sapiens Unknown (protein for IM... 118 7e-26
AK222703-1|BAD96423.1| 542|Homo sapiens calcium/calmodulin-depe... 118 7e-26
AB208859-1|BAD92096.1| 917|Homo sapiens calcium/calmodulin-depe... 118 7e-26
X85545-1|CAA59733.1| 358|Homo sapiens protein kinase protein. 118 9e-26
L07032-1|AAA60101.1| 706|Homo sapiens protein kinase C-theta pr... 118 9e-26
L01087-1|AAA75571.1| 706|Homo sapiens protein kinase C-theta pr... 118 9e-26
BC113359-1|AAI13360.1| 706|Homo sapiens protein kinase C, theta... 118 9e-26
BC101465-1|AAI01466.1| 706|Homo sapiens protein kinase C, theta... 118 9e-26
BC041073-1|AAH41073.1| 358|Homo sapiens protein kinase, X-linke... 118 9e-26
AL158043-2|CAC12904.2| 706|Homo sapiens protein kinase C, theta... 118 9e-26
AL158043-1|CAI16127.1| 478|Homo sapiens protein kinase C, theta... 118 9e-26
AL137145-2|CAC10200.2| 706|Homo sapiens protein kinase C, theta... 118 9e-26
AL137145-1|CAI15756.1| 478|Homo sapiens protein kinase C, theta... 118 9e-26
X65293-1|CAA46388.1| 737|Homo sapiens protein kinase C epsilon... 117 1e-25
M63167-1|AAA36539.1| 480|Homo sapiens rac protein kinase-alpha ... 117 1e-25
BC109034-1|AAI09035.1| 737|Homo sapiens protein kinase C, epsil... 117 1e-25
BC109033-1|AAI09034.1| 737|Homo sapiens protein kinase C, epsil... 117 1e-25
BC084538-1|AAH84538.1| 480|Homo sapiens v-akt murine thymoma vi... 117 1e-25
BC021269-1|AAH21269.2| 453|Homo sapiens CAMK2G protein protein. 117 1e-25
BC017575-1|AAH17575.1| 476|Homo sapiens CHK1 checkpoint homolog... 117 1e-25
BC004202-1|AAH04202.1| 476|Homo sapiens CHEK1 protein protein. 117 1e-25
BC000479-1|AAH00479.1| 480|Homo sapiens v-akt murine thymoma vi... 117 1e-25
AL713896-1|CAI13787.1| 453|Homo sapiens calcium/calmodulin-depe... 117 1e-25
AL596247-1|CAI13964.1| 453|Homo sapiens calcium/calmodulin-depe... 117 1e-25
AL121914-4|CAM45838.1| 347|Homo sapiens aurora kinase A protein. 117 1e-25
AF527555-1|AAM78553.1| 476|Homo sapiens CHK1 checkpoint homolog... 117 1e-25
AF283830-1|AAL55732.1| 480|Homo sapiens AKT1 protein. 117 1e-25
AF032874-1|AAB88852.1| 476|Homo sapiens protein kinase protein. 117 1e-25
AF016582-1|AAC51736.1| 476|Homo sapiens Chk1 protein. 117 1e-25
AB032387-1|BAA84577.1| 476|Homo sapiens checkpoint kinase protein. 117 1e-25
M60725-1|AAA36411.1| 502|Homo sapiens p70 ribosomal S6 kinase a... 116 2e-25
M60724-1|AAA36410.1| 525|Homo sapiens p70 ribosomal S6 kinase a... 116 2e-25
L07043-1|AAB61379.1| 306|Homo sapiens calcium/calmodulin-depend... 116 2e-25
BC053365-1|AAH53365.1| 451|Homo sapiens RPS6KB1 protein protein. 116 2e-25
BC013879-1|AAH13879.1| 685|Homo sapiens polo-like kinase 2 (Dro... 116 2e-25
AL450063-11|CAI16854.1| 264|Homo sapiens protein kinase, cAMP-d... 116 2e-25
AK098163-1|BAC05247.1| 372|Homo sapiens protein ( Homo sapiens ... 116 2e-25
AF223574-1|AAF62897.1| 685|Homo sapiens serum-inducible kinase ... 116 2e-25
AF059617-1|AAC14573.1| 685|Homo sapiens serum-inducible kinase ... 116 2e-25
Y15801-1|CAA75792.1| 277|Homo sapiens protein kinase protein. 116 3e-25
Y13927-1|CAA74244.1| 277|Homo sapiens protein kinase protein. 116 3e-25
BC074852-1|AAH74852.1| 277|Homo sapiens protein kinase, Y-linke... 116 3e-25
BC074851-1|AAH74851.1| 277|Homo sapiens protein kinase, Y-linke... 116 3e-25
AB033104-1|BAA86592.1| 1311|Homo sapiens KIAA1278 protein protein. 116 3e-25
AB209475-1|BAD92712.1| 461|Homo sapiens protein kinase C, alpha... 116 3e-25
BC034988-1|AAH34988.1| 1036|Homo sapiens ULK2 protein protein. 115 6e-25
AK131198-1|BAD18393.1| 706|Homo sapiens protein ( Homo sapiens ... 115 6e-25
AF262405-1|AAF72667.1| 871|Homo sapiens calcium/calmodulin-depe... 115 6e-25
AF200815-1|AAF97028.1| 1315|Homo sapiens FUSED serine/threonine ... 115 6e-25
AF015254-1|AAC98891.1| 347|Homo sapiens serine/threonine kinase... 115 6e-25
AB014523-1|BAA31598.2| 1100|Homo sapiens KIAA0623 protein protein. 115 6e-25
BC069655-1|AAH69655.1| 390|Homo sapiens PHKG1 protein protein. 114 8e-25
BC026158-1|AAH26158.1| 1315|Homo sapiens serine/threonine kinase... 114 8e-25
BC016285-1|AAH16285.1| 257|Homo sapiens protein kinase, cAMP-de... 114 8e-25
AL450063-7|CAI16850.1| 245|Homo sapiens protein kinase, cAMP-de... 114 8e-25
AL450063-1|CAI16844.1| 257|Homo sapiens protein kinase, cAMP-de... 114 8e-25
AL359504-1|CAI14540.1| 257|Homo sapiens protein kinase, cAMP-de... 114 8e-25
AB011446-1|BAA82709.1| 343|Homo sapiens Aik2 protein. 114 8e-25
X76104-1|CAA53712.1| 1431|Homo sapiens DAP-kinase protein. 114 1e-24
DQ436495-1|ABD96827.1| 1430|Homo sapiens death-associated protei... 114 1e-24
BT006935-1|AAP35581.1| 367|Homo sapiens death-associated protei... 114 1e-24
BC126432-1|AAI26433.1| 454|Homo sapiens death-associated protei... 114 1e-24
BC126430-1|AAI26431.1| 454|Homo sapiens death-associated protei... 114 1e-24
BC113660-1|AAI13661.1| 1430|Homo sapiens death-associated protei... 114 1e-24
BC019256-1|AAH19256.1| 501|Homo sapiens CaM kinase-like vesicle... 114 1e-24
BC017363-1|AAH17363.1| 501|Homo sapiens CaM kinase-like vesicle... 114 1e-24
BC012622-1|AAH12622.1| 207|Homo sapiens PRKAA1 protein protein. 114 1e-24
BC005828-1|AAH05828.1| 501|Homo sapiens CaM kinase-like vesicle... 114 1e-24
BC001921-1|AAH01921.1| 501|Homo sapiens CaM kinase-like vesicle... 114 1e-24
BC000497-1|AAH00497.1| 501|Homo sapiens CaM kinase-like vesicle... 114 1e-24
AL591852-1|CAH71696.1| 1455|Homo sapiens death-associated protei... 114 1e-24
AL161787-1|CAH73544.1| 1455|Homo sapiens death-associated protei... 114 1e-24
AL160279-1|CAI16306.1| 1455|Homo sapiens death-associated protei... 114 1e-24
AK074899-1|BAC11278.1| 470|Homo sapiens protein ( Homo sapiens ... 114 1e-24
AF004022-1|AAB65786.1| 347|Homo sapiens protein kinase protein. 114 1e-24
AB208871-1|BAD92108.1| 1433|Homo sapiens Hypothetical protein DK... 114 1e-24
AB022341-1|BAA81746.1| 454|Homo sapiens ZIP kinase protein. 114 1e-24
AB007144-1|BAA24955.1| 454|Homo sapiens ZIP-kinase protein. 114 1e-24
AK075294-1|BAC11528.1| 470|Homo sapiens protein ( Homo sapiens ... 113 1e-24
BC056423-1|AAH56423.1| 214|Homo sapiens ULK3 protein protein. 113 2e-24
BC036117-1|AAH36117.1| 214|Homo sapiens ULK3 protein protein. 113 2e-24
U85755-1|AAD00575.1| 299|Homo sapiens serum-inducible kinase pr... 113 2e-24
U33052-1|AAC50208.1| 984|Homo sapiens PRK2 protein. 113 2e-24
S75548-1|AAB33346.1| 984|Homo sapiens protein kinase PRK2 protein. 113 2e-24
BC125199-1|AAI25200.1| 936|Homo sapiens PKN2 protein protein. 113 2e-24
AL136381-3|CAI23271.1| 984|Homo sapiens protein kinase N2 protein. 113 2e-24
X61037-1|CAA43372.1| 417|Homo sapiens human protein kinase B p... 112 3e-24
BC037268-1|AAH37268.1| 683|Homo sapiens protein kinase C, eta p... 112 3e-24
M55284-1|AAA60100.1| 682|Homo sapiens protein kinase C-L protein. 111 7e-24
Y11950-1|CAA72694.1| 406|Homo sapiens phosphorylase kinase gamm... 111 1e-23
M31606-1|AAA36442.1| 406|Homo sapiens phosphorylase kinase prot... 111 1e-23
BC002541-1|AAH02541.1| 406|Homo sapiens phosphorylase kinase, g... 111 1e-23
U33053-1|AAC50209.1| 942|Homo sapiens PRK1 protein. 110 1e-23
S75546-1|AAB33345.1| 942|Homo sapiens protein kinase PRK1 protein. 110 1e-23
D86968-1|BAA13204.2| 1626|Homo sapiens KIAA0213 protein. 110 1e-23
D26181-1|BAA05169.1| 942|Homo sapiens PKN protein. 110 1e-23
BC040061-1|AAH40061.1| 942|Homo sapiens protein kinase N1 protein. 110 1e-23
AF002715-1|AAB68804.1| 1607|Homo sapiens MAP kinase kinase kinas... 110 1e-23
Z29067-1|CAA82310.1| 459|Homo sapiens protein kinase protein. 110 2e-23
U56998-1|AAC50637.1| 607|Homo sapiens putative serine/threonine... 109 2e-23
BC013899-1|AAH13899.1| 646|Homo sapiens polo-like kinase 3 (Dro... 109 2e-23
AY764184-1|AAU88146.1| 646|Homo sapiens polo-like kinase 3 (Dro... 109 2e-23
AL592166-11|CAI13006.1| 646|Homo sapiens polo-like kinase 3 (Dr... 109 2e-23
AF045458-1|AAC32326.1| 1050|Homo sapiens serine/threonine kinase... 109 2e-23
AB209875-1|BAD93112.1| 621|Homo sapiens polo-like kinase 3 vari... 109 2e-23
AB018265-1|BAA34442.2| 1066|Homo sapiens KIAA0722 protein protein. 109 2e-23
BC063585-1|AAH63585.1| 1323|Homo sapiens PAS domain containing s... 109 3e-23
BC043495-1|AAH43495.1| 953|Homo sapiens PASK protein protein. 109 3e-23
AJ293866-1|CAC10659.1| 646|Homo sapiens FNK serine/threonine pr... 109 3e-23
AF387103-1|AAK69752.1| 1323|Homo sapiens PAS-kinase protein. 109 3e-23
AL390029-2|CAI15721.1| 740|Homo sapiens doublecortin and CaM ki... 109 4e-23
AL390029-1|CAI15720.1| 729|Homo sapiens doublecortin and CaM ki... 109 4e-23
AL160392-2|CAH70261.1| 740|Homo sapiens doublecortin and CaM ki... 109 4e-23
AL160392-1|CAH70262.1| 729|Homo sapiens doublecortin and CaM ki... 109 4e-23
AL157760-4|CAH70170.1| 433|Homo sapiens doublecortin and CaM ki... 109 4e-23
AL157760-2|CAH70168.1| 729|Homo sapiens doublecortin and CaM ki... 109 4e-23
AL157760-1|CAH70167.1| 740|Homo sapiens doublecortin and CaM ki... 109 4e-23
AL157694-2|CAH70657.1| 729|Homo sapiens doublecortin and CaM ki... 109 4e-23
AL157694-1|CAH70656.1| 740|Homo sapiens doublecortin and CaM ki... 109 4e-23
AB002367-1|BAA20824.2| 794|Homo sapiens KIAA0369 protein. 109 4e-23
U43195-1|AAB02814.1| 1354|Homo sapiens Rho-associated, coiled-co... 108 5e-23
AK074856-1|BAC11248.1| 501|Homo sapiens protein ( Homo sapiens ... 108 5e-23
X80229-1|CAA56515.1| 479|Homo sapiens serine/threonine protein ... 108 7e-23
>BC022515-1|AAH22515.1| 367|Homo sapiens testis-specific serine
kinase 1B protein.
Length = 367
Score = 235 bits (576), Expect = 3e-61
Identities = 120/277 (43%), Positives = 177/277 (63%), Gaps = 8/277 (2%)
Query: 14 LLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREID 73
L +GY L +GEG+YAKV S+ + K +A KII+ KAP DF+ KFLPREI+
Sbjct: 7 LKRRGYLLGINLGEGSYAKVK----SAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIE 62
Query: 74 VLVRLNHPHLIHVHSIFQRKT-KYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLAL 132
+L LNH +I + IF+ K YI M GDLL I G + E++AR QL+L
Sbjct: 63 ILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSL 122
Query: 133 GLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDN-QPVLSETYCGSMSYA 191
++Y H+L++ HRD+KC+N+LL +FN+KLSDF FS+ C+ D+ + LS+T+CGS +YA
Sbjct: 123 AIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYA 182
Query: 192 APEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASI 251
APE+L+G PY PK D+WSLGV+L++M+ SMP+DD+ ++K+ Q K++R +
Sbjct: 183 APEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQ--KEHRVNFPRSKH 240
Query: 252 LSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSR 288
L+ ECK ++ H+L+PD R +L W+ +R
Sbjct: 241 LTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKAR 277
Score = 221 bits (539), Expect = 8e-57
Identities = 116/277 (41%), Positives = 179/277 (64%), Gaps = 10/277 (3%)
Query: 319 KRQGDILEGPTRESAFRVYLAEYRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEM 378
KR+G +L E ++ + Y S+ K ++ A K+ID AP DF++KFLPREIE+
Sbjct: 8 KRRGYLLGINLGEGSYAKVKSAY---SERLKFNV-AIKIIDRKKAPADFLEKFLPREIEI 63
Query: 379 LIKLSHPHLVHTHSIFQRRY-KYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALA 437
L L+H ++ T+ IF+ + K +I M +GDLLE + RGA+ ED+AR QL+LA
Sbjct: 64 LAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLA 123
Query: 438 IQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCV-DKKLNEIRSETFCGSLSYTA 496
I+Y H+L++ HRD+KC+N+LL + N+KLSDF F++ C+ D S+TFCGS +Y A
Sbjct: 124 IKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAA 183
Query: 497 PEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKF-RSRYIDT 555
PE+LQG PY PK D+WSLG+++Y+M+ +MP++D +IK++ + Q F RS++
Sbjct: 184 PEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKH--- 240
Query: 556 ISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSR 592
++ CK LI ML+P+ RL I +I++ W+ +R
Sbjct: 241 LTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKAR 277
>AY028964-1|AAK27734.1| 367|Homo sapiens testis-specific
serine/threonine kinase 1 protein.
Length = 367
Score = 235 bits (576), Expect = 3e-61
Identities = 120/277 (43%), Positives = 177/277 (63%), Gaps = 8/277 (2%)
Query: 14 LLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREID 73
L +GY L +GEG+YAKV S+ + K +A KII+ KAP DF+ KFLPREI+
Sbjct: 7 LKRRGYLLGINLGEGSYAKVK----SAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIE 62
Query: 74 VLVRLNHPHLIHVHSIFQRKT-KYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLAL 132
+L LNH +I + IF+ K YI M GDLL I G + E++AR QL+L
Sbjct: 63 ILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSL 122
Query: 133 GLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDN-QPVLSETYCGSMSYA 191
++Y H+L++ HRD+KC+N+LL +FN+KLSDF FS+ C+ D+ + LS+T+CGS +YA
Sbjct: 123 AIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYA 182
Query: 192 APEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASI 251
APE+L+G PY PK D+WSLGV+L++M+ SMP+DD+ ++K+ Q K++R +
Sbjct: 183 APEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQ--KEHRVNFPRSKH 240
Query: 252 LSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSR 288
L+ ECK ++ H+L+PD R +L W+ +R
Sbjct: 241 LTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKAR 277
Score = 221 bits (539), Expect = 8e-57
Identities = 116/277 (41%), Positives = 179/277 (64%), Gaps = 10/277 (3%)
Query: 319 KRQGDILEGPTRESAFRVYLAEYRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEM 378
KR+G +L E ++ + Y S+ K ++ A K+ID AP DF++KFLPREIE+
Sbjct: 8 KRRGYLLGINLGEGSYAKVKSAY---SERLKFNV-AIKIIDRKKAPADFLEKFLPREIEI 63
Query: 379 LIKLSHPHLVHTHSIFQRRY-KYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALA 437
L L+H ++ T+ IF+ + K +I M +GDLLE + RGA+ ED+AR QL+LA
Sbjct: 64 LAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLA 123
Query: 438 IQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCV-DKKLNEIRSETFCGSLSYTA 496
I+Y H+L++ HRD+KC+N+LL + N+KLSDF F++ C+ D S+TFCGS +Y A
Sbjct: 124 IKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAA 183
Query: 497 PEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKF-RSRYIDT 555
PE+LQG PY PK D+WSLG+++Y+M+ +MP++D +IK++ + Q F RS++
Sbjct: 184 PEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKH--- 240
Query: 556 ISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSR 592
++ CK LI ML+P+ RL I +I++ W+ +R
Sbjct: 241 LTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKAR 277
>AB284522-1|BAF41973.1| 367|Homo sapiens testis-specific serine
kinase 1 protein.
Length = 367
Score = 235 bits (576), Expect = 3e-61
Identities = 120/277 (43%), Positives = 177/277 (63%), Gaps = 8/277 (2%)
Query: 14 LLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREID 73
L +GY L +GEG+YAKV S+ + K +A KII+ KAP DF+ KFLPREI+
Sbjct: 7 LKRRGYLLGINLGEGSYAKVK----SAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIE 62
Query: 74 VLVRLNHPHLIHVHSIFQRKT-KYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLAL 132
+L LNH +I + IF+ K YI M GDLL I G + E++AR QL+L
Sbjct: 63 ILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSL 122
Query: 133 GLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDN-QPVLSETYCGSMSYA 191
++Y H+L++ HRD+KC+N+LL +FN+KLSDF FS+ C+ D+ + LS+T+CGS +YA
Sbjct: 123 AIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYA 182
Query: 192 APEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASI 251
APE+L+G PY PK D+WSLGV+L++M+ SMP+DD+ ++K+ Q K++R +
Sbjct: 183 APEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQ--KEHRVNFPRSKH 240
Query: 252 LSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSR 288
L+ ECK ++ H+L+PD R +L W+ +R
Sbjct: 241 LTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKAR 277
Score = 221 bits (539), Expect = 8e-57
Identities = 116/277 (41%), Positives = 179/277 (64%), Gaps = 10/277 (3%)
Query: 319 KRQGDILEGPTRESAFRVYLAEYRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEM 378
KR+G +L E ++ + Y S+ K ++ A K+ID AP DF++KFLPREIE+
Sbjct: 8 KRRGYLLGINLGEGSYAKVKSAY---SERLKFNV-AIKIIDRKKAPADFLEKFLPREIEI 63
Query: 379 LIKLSHPHLVHTHSIFQRRY-KYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALA 437
L L+H ++ T+ IF+ + K +I M +GDLLE + RGA+ ED+AR QL+LA
Sbjct: 64 LAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLA 123
Query: 438 IQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCV-DKKLNEIRSETFCGSLSYTA 496
I+Y H+L++ HRD+KC+N+LL + N+KLSDF F++ C+ D S+TFCGS +Y A
Sbjct: 124 IKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAA 183
Query: 497 PEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKF-RSRYIDT 555
PE+LQG PY PK D+WSLG+++Y+M+ +MP++D +IK++ + Q F RS++
Sbjct: 184 PEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKH--- 240
Query: 556 ISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSR 592
++ CK LI ML+P+ RL I +I++ W+ +R
Sbjct: 241 LTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKAR 277
>CR456587-1|CAG30473.1| 358|Homo sapiens STK22A protein.
Length = 358
Score = 231 bits (566), Expect = 4e-60
Identities = 117/276 (42%), Positives = 176/276 (63%), Gaps = 8/276 (2%)
Query: 10 EENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLP 69
+ L KGY + +G+G+YAKV S+ + K +A KII+ K P DFV +FLP
Sbjct: 3 DATVLRKKGYIVGINLGKGSYAKVK----SAYSERLKFNVAVKIIDRKKTPTDFVERFLP 58
Query: 70 REIDVLVRLNHPHLIHVHSIFQRKT-KYYIFMRYTENGDLLSYILKNGCVSENQARVWTR 128
RE+D+L +NH +I + IF+ + YI M GDLL +I G + E+ AR R
Sbjct: 59 REMDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFR 118
Query: 129 QLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCV-ESDNQPVLSETYCGS 187
QL+ ++Y H+L+I HRD+KCEN+LL +FN+KLSDFGFS+ C+ +S+ + +LS+T+CGS
Sbjct: 119 QLSSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGS 178
Query: 188 MSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSR 247
+YAAPE+L+ PY PK D+WSLGV+L++M+ SMP+DD+ +RK+ Q K++R
Sbjct: 179 AAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQ--KEHRVDFP 236
Query: 248 VASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+ L+ ECK ++ +L+PD R +L W+
Sbjct: 237 RSKNLTCECKDLIYRMLQPDVSQRLHIDEILSHSWL 272
Score = 212 bits (517), Expect = 4e-54
Identities = 103/238 (43%), Positives = 159/238 (66%), Gaps = 6/238 (2%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRY-KYFIFMRYMERGD 411
+A K+ID P DFV++FLPRE+++L ++H ++ T+ IF+ + +I M +GD
Sbjct: 38 VAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGD 97
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
LLEF+ +GA+ ED AR RQL+ A++Y H+L+I HRD+KCEN+LL + N+KLSDFGF
Sbjct: 98 LLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGF 157
Query: 472 ARMCV-DKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
++ C+ D I S+TFCGS +Y APE+LQ PY PK D+WSLG+++Y+M+ +MP++
Sbjct: 158 SKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYD 217
Query: 531 DKHIKQLHQAQINKNWKF-RSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
D I+++ + Q F RS+ ++ CK LI ML+P+ RL I +I++ W+
Sbjct: 218 DSDIRKMLRIQKEHRVDFPRSK---NLTCECKDLIYRMLQPDVSQRLHIDEILSHSWL 272
>BC037781-1|AAH37781.1| 358|Homo sapiens testis-specific serine
kinase 2 protein.
Length = 358
Score = 231 bits (566), Expect = 4e-60
Identities = 117/276 (42%), Positives = 176/276 (63%), Gaps = 8/276 (2%)
Query: 10 EENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLP 69
+ L KGY + +G+G+YAKV S+ + K +A KII+ K P DFV +FLP
Sbjct: 3 DATVLRKKGYIVGINLGKGSYAKVK----SAYSERLKFNVAVKIIDRKKTPTDFVERFLP 58
Query: 70 REIDVLVRLNHPHLIHVHSIFQRKT-KYYIFMRYTENGDLLSYILKNGCVSENQARVWTR 128
RE+D+L +NH +I + IF+ + YI M GDLL +I G + E+ AR R
Sbjct: 59 REMDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFR 118
Query: 129 QLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCV-ESDNQPVLSETYCGS 187
QL+ ++Y H+L+I HRD+KCEN+LL +FN+KLSDFGFS+ C+ +S+ + +LS+T+CGS
Sbjct: 119 QLSSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGS 178
Query: 188 MSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSR 247
+YAAPE+L+ PY PK D+WSLGV+L++M+ SMP+DD+ +RK+ Q K++R
Sbjct: 179 AAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQ--KEHRVDFP 236
Query: 248 VASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+ L+ ECK ++ +L+PD R +L W+
Sbjct: 237 RSKNLTCECKDLIYRMLQPDVSQRLHIDEILSHSWL 272
Score = 212 bits (517), Expect = 4e-54
Identities = 103/238 (43%), Positives = 159/238 (66%), Gaps = 6/238 (2%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRY-KYFIFMRYMERGD 411
+A K+ID P DFV++FLPRE+++L ++H ++ T+ IF+ + +I M +GD
Sbjct: 38 VAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGD 97
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
LLEF+ +GA+ ED AR RQL+ A++Y H+L+I HRD+KCEN+LL + N+KLSDFGF
Sbjct: 98 LLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGF 157
Query: 472 ARMCV-DKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
++ C+ D I S+TFCGS +Y APE+LQ PY PK D+WSLG+++Y+M+ +MP++
Sbjct: 158 SKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYD 217
Query: 531 DKHIKQLHQAQINKNWKF-RSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
D I+++ + Q F RS+ ++ CK LI ML+P+ RL I +I++ W+
Sbjct: 218 DSDIRKMLRIQKEHRVDFPRSK---NLTCECKDLIYRMLQPDVSQRLHIDEILSHSWL 272
>AF362953-1|AAK98531.1| 358|Homo sapiens testis specific
serine/threonine kinase 2 protein.
Length = 358
Score = 231 bits (566), Expect = 4e-60
Identities = 117/276 (42%), Positives = 176/276 (63%), Gaps = 8/276 (2%)
Query: 10 EENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLP 69
+ L KGY + +G+G+YAKV S+ + K +A KII+ K P DFV +FLP
Sbjct: 3 DATVLRKKGYIVGINLGKGSYAKVK----SAYSERLKFNVAVKIIDRKKTPTDFVERFLP 58
Query: 70 REIDVLVRLNHPHLIHVHSIFQRKT-KYYIFMRYTENGDLLSYILKNGCVSENQARVWTR 128
RE+D+L +NH +I + IF+ + YI M GDLL +I G + E+ AR R
Sbjct: 59 REMDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFR 118
Query: 129 QLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCV-ESDNQPVLSETYCGS 187
QL+ ++Y H+L+I HRD+KCEN+LL +FN+KLSDFGFS+ C+ +S+ + +LS+T+CGS
Sbjct: 119 QLSSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGS 178
Query: 188 MSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSR 247
+YAAPE+L+ PY PK D+WSLGV+L++M+ SMP+DD+ +RK+ Q K++R
Sbjct: 179 AAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQ--KEHRVDFP 236
Query: 248 VASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+ L+ ECK ++ +L+PD R +L W+
Sbjct: 237 RSKNLTCECKDLIYRMLQPDVSQRLHIDEILSHSWL 272
Score = 213 bits (521), Expect = 1e-54
Identities = 111/285 (38%), Positives = 177/285 (62%), Gaps = 11/285 (3%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRY-KYFIFMRYMERGD 411
+A K+ID P DFV++FLPRE+++L ++H ++ T+ IF+ + +I M +GD
Sbjct: 38 VAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGD 97
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
LLEF+ +GA+ ED AR RQL+ A++Y H+L+I HRD+KCEN+LL + N+KLSDFGF
Sbjct: 98 LLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGF 157
Query: 472 ARMCV-DKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
++ C+ D I S+TFCGS +Y APE+LQ PY PK D+WSLG+++Y+M+ +MP++
Sbjct: 158 SKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYD 217
Query: 531 DKHIKQLHQAQINKNWKF-RSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAM 589
D I+++ + Q F RS+ ++ CK LI ML+P+ RL I +I++ W+
Sbjct: 218 DSDIRKMLRIQKEHRVDFPRSK---NLTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQP 274
Query: 590 DSRLLEWTPQETLAYKKAREEKNKLHKTVET-VELPGSSKTEHKV 633
P + ++K+ E K + ++T L + +HK+
Sbjct: 275 PKP----KPTSSASFKREGEGKYRAECKLDTKTGLRPDHRPDHKL 315
>AB284523-1|BAF41974.1| 358|Homo sapiens testis-specific serine
kinase 2 protein.
Length = 358
Score = 231 bits (566), Expect = 4e-60
Identities = 117/276 (42%), Positives = 176/276 (63%), Gaps = 8/276 (2%)
Query: 10 EENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLP 69
+ L KGY + +G+G+YAKV S+ + K +A KII+ K P DFV +FLP
Sbjct: 3 DATVLRKKGYIVGINLGKGSYAKVK----SAYSERLKFNVAVKIIDRKKTPTDFVERFLP 58
Query: 70 REIDVLVRLNHPHLIHVHSIFQRKT-KYYIFMRYTENGDLLSYILKNGCVSENQARVWTR 128
RE+D+L +NH +I + IF+ + YI M GDLL +I G + E+ AR R
Sbjct: 59 REMDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFR 118
Query: 129 QLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCV-ESDNQPVLSETYCGS 187
QL+ ++Y H+L+I HRD+KCEN+LL +FN+KLSDFGFS+ C+ +S+ + +LS+T+CGS
Sbjct: 119 QLSSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGS 178
Query: 188 MSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSR 247
+YAAPE+L+ PY PK D+WSLGV+L++M+ SMP+DD+ +RK+ Q K++R
Sbjct: 179 AAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQ--KEHRVDFP 236
Query: 248 VASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+ L+ ECK ++ +L+PD R +L W+
Sbjct: 237 RSKNLTCECKDLIYRMLQPDVSQRLHIDEILSHSWL 272
Score = 212 bits (517), Expect = 4e-54
Identities = 103/238 (43%), Positives = 159/238 (66%), Gaps = 6/238 (2%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRY-KYFIFMRYMERGD 411
+A K+ID P DFV++FLPRE+++L ++H ++ T+ IF+ + +I M +GD
Sbjct: 38 VAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGD 97
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
LLEF+ +GA+ ED AR RQL+ A++Y H+L+I HRD+KCEN+LL + N+KLSDFGF
Sbjct: 98 LLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGF 157
Query: 472 ARMCV-DKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
++ C+ D I S+TFCGS +Y APE+LQ PY PK D+WSLG+++Y+M+ +MP++
Sbjct: 158 SKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYD 217
Query: 531 DKHIKQLHQAQINKNWKF-RSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
D I+++ + Q F RS+ ++ CK LI ML+P+ RL I +I++ W+
Sbjct: 218 DSDIRKMLRIQKEHRVDFPRSK---NLTCECKDLIYRMLQPDVSQRLHIDEILSHSWL 272
>BC035354-1|AAH35354.1| 268|Homo sapiens testis-specific serine
kinase 3 protein.
Length = 268
Score = 212 bits (518), Expect = 3e-54
Identities = 113/275 (41%), Positives = 175/275 (63%), Gaps = 11/275 (4%)
Query: 11 ENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPR 70
E+ LL+ GY+L K +GEG Y+KV E SK+ H+ +A K+I+ P++F+ +FLPR
Sbjct: 2 EDFLLSNGYQLGKTIGEGTYSKV--KEAFSKK--HQRKVAIKVIDKMGGPEEFIQRFLPR 57
Query: 71 EIDVLVRLNHPHLIHVHSIFQRKT-KYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQ 129
E+ ++ L+H ++I V+ + + K + M E GD+ +L G + E++A+ RQ
Sbjct: 58 ELQIVRTLDHKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQ 117
Query: 130 LALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMS 189
+ ++Y H +AHRD+KCEN LL FN+KL+DFGF++ +S + LS+T+CGS +
Sbjct: 118 MVEAIRYCHGCGVAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRE--LSQTFCGSTA 174
Query: 190 YAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVA 249
YAAPE+L+G P+ K D+WS+GVVL+VML S+PFDDT + K+ QQ K F + ++
Sbjct: 175 YAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQ-KGVSFPTHLS 233
Query: 250 SILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIA 284
+S +C+ ++K LLEPD LR S V W+A
Sbjct: 234 --ISADCQDLLKRLLEPDMILRPSIEEVSWHPWLA 266
Score = 173 bits (420), Expect = 2e-42
Identities = 96/238 (40%), Positives = 147/238 (61%), Gaps = 9/238 (3%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRY-KYFIFMRYMERGD 411
+A KVID P +F+++FLPRE++++ L H +++ + + + K + M E GD
Sbjct: 36 VAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKNIIQVYEMLESADGKICLVMELAEGGD 95
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
+ + VL G + E +A+ RQ+ AI+Y H +AHRD+KCEN LL N+KL+DFGF
Sbjct: 96 VFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQGF-NLKLTDFGF 154
Query: 472 ARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFED 531
A++ + K E+ S+TFCGS +Y APE+LQG P+ K DVWS+G+V+YVML ++PF+D
Sbjct: 155 AKV-LPKSHREL-SQTFCGSTAYAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCASLPFDD 212
Query: 532 KHI-KQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIA 588
I K L Q Q K F + +IS +C+ L+ +LEP+ R I ++ W+A
Sbjct: 213 TDIPKMLWQQQ--KGVSFPTHL--SISADCQDLLKRLLEPDMILRPSIEEVSWHPWLA 266
>AY048701-1|AAL02128.1| 268|Homo sapiens TSSK3 protein.
Length = 268
Score = 212 bits (518), Expect = 3e-54
Identities = 113/275 (41%), Positives = 175/275 (63%), Gaps = 11/275 (4%)
Query: 11 ENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPR 70
E+ LL+ GY+L K +GEG Y+KV E SK+ H+ +A K+I+ P++F+ +FLPR
Sbjct: 2 EDFLLSNGYQLGKTIGEGTYSKV--KEAFSKK--HQRKVAIKVIDKMGGPEEFIQRFLPR 57
Query: 71 EIDVLVRLNHPHLIHVHSIFQRKT-KYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQ 129
E+ ++ L+H ++I V+ + + K + M E GD+ +L G + E++A+ RQ
Sbjct: 58 ELQIVRTLDHKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQ 117
Query: 130 LALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMS 189
+ ++Y H +AHRD+KCEN LL FN+KL+DFGF++ +S + LS+T+CGS +
Sbjct: 118 MVEAIRYCHGCGVAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRE--LSQTFCGSTA 174
Query: 190 YAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVA 249
YAAPE+L+G P+ K D+WS+GVVL+VML S+PFDDT + K+ QQ K F + ++
Sbjct: 175 YAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQ-KGVSFPTHLS 233
Query: 250 SILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIA 284
+S +C+ ++K LLEPD LR S V W+A
Sbjct: 234 --ISADCQDLLKRLLEPDMILRPSIEEVSWHPWLA 266
Score = 173 bits (420), Expect = 2e-42
Identities = 96/238 (40%), Positives = 147/238 (61%), Gaps = 9/238 (3%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRY-KYFIFMRYMERGD 411
+A KVID P +F+++FLPRE++++ L H +++ + + + K + M E GD
Sbjct: 36 VAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKNIIQVYEMLESADGKICLVMELAEGGD 95
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
+ + VL G + E +A+ RQ+ AI+Y H +AHRD+KCEN LL N+KL+DFGF
Sbjct: 96 VFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQGF-NLKLTDFGF 154
Query: 472 ARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFED 531
A++ + K E+ S+TFCGS +Y APE+LQG P+ K DVWS+G+V+YVML ++PF+D
Sbjct: 155 AKV-LPKSHREL-SQTFCGSTAYAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCASLPFDD 212
Query: 532 KHI-KQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIA 588
I K L Q Q K F + +IS +C+ L+ +LEP+ R I ++ W+A
Sbjct: 213 TDIPKMLWQQQ--KGVSFPTHL--SISADCQDLLKRLLEPDMILRPSIEEVSWHPWLA 266
>AL109945-4|CAI22888.1| 268|Homo sapiens testis-specific serine
kinase 3 protein.
Length = 268
Score = 212 bits (518), Expect = 3e-54
Identities = 113/275 (41%), Positives = 175/275 (63%), Gaps = 11/275 (4%)
Query: 11 ENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPR 70
E+ LL+ GY+L K +GEG Y+KV E SK+ H+ +A K+I+ P++F+ +FLPR
Sbjct: 2 EDFLLSNGYQLGKTIGEGTYSKV--KEAFSKK--HQRKVAIKVIDKMGGPEEFIQRFLPR 57
Query: 71 EIDVLVRLNHPHLIHVHSIFQRKT-KYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQ 129
E+ ++ L+H ++I V+ + + K + M E GD+ +L G + E++A+ RQ
Sbjct: 58 ELQIVRTLDHKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQ 117
Query: 130 LALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMS 189
+ ++Y H +AHRD+KCEN LL FN+KL+DFGF++ +S + LS+T+CGS +
Sbjct: 118 MVEAIRYCHGCGVAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRE--LSQTFCGSTA 174
Query: 190 YAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVA 249
YAAPE+L+G P+ K D+WS+GVVL+VML S+PFDDT + K+ QQ K F + ++
Sbjct: 175 YAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQ-KGVSFPTHLS 233
Query: 250 SILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIA 284
+S +C+ ++K LLEPD LR S V W+A
Sbjct: 234 --ISADCQDLLKRLLEPDMILRPSIEEVSWHPWLA 266
Score = 173 bits (420), Expect = 2e-42
Identities = 96/238 (40%), Positives = 147/238 (61%), Gaps = 9/238 (3%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRY-KYFIFMRYMERGD 411
+A KVID P +F+++FLPRE++++ L H +++ + + + K + M E GD
Sbjct: 36 VAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKNIIQVYEMLESADGKICLVMELAEGGD 95
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
+ + VL G + E +A+ RQ+ AI+Y H +AHRD+KCEN LL N+KL+DFGF
Sbjct: 96 VFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQGF-NLKLTDFGF 154
Query: 472 ARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFED 531
A++ + K E+ S+TFCGS +Y APE+LQG P+ K DVWS+G+V+YVML ++PF+D
Sbjct: 155 AKV-LPKSHREL-SQTFCGSTAYAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCASLPFDD 212
Query: 532 KHI-KQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIA 588
I K L Q Q K F + +IS +C+ L+ +LEP+ R I ++ W+A
Sbjct: 213 TDIPKMLWQQQ--KGVSFPTHL--SISADCQDLLKRLLEPDMILRPSIEEVSWHPWLA 266
>AF296450-1|AAK97141.1| 268|Homo sapiens testis-specific
serine/threonine kinase 3 protein.
Length = 268
Score = 212 bits (518), Expect = 3e-54
Identities = 113/275 (41%), Positives = 175/275 (63%), Gaps = 11/275 (4%)
Query: 11 ENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPR 70
E+ LL+ GY+L K +GEG Y+KV E SK+ H+ +A K+I+ P++F+ +FLPR
Sbjct: 2 EDFLLSNGYQLGKTIGEGTYSKV--KEAFSKK--HQRKVAIKVIDKMGGPEEFIQRFLPR 57
Query: 71 EIDVLVRLNHPHLIHVHSIFQRKT-KYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQ 129
E+ ++ L+H ++I V+ + + K + M E GD+ +L G + E++A+ RQ
Sbjct: 58 ELQIVRTLDHKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQ 117
Query: 130 LALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMS 189
+ ++Y H +AHRD+KCEN LL FN+KL+DFGF++ +S + LS+T+CGS +
Sbjct: 118 MVEAIRYCHGCGVAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRE--LSQTFCGSTA 174
Query: 190 YAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVA 249
YAAPE+L+G P+ K D+WS+GVVL+VML S+PFDDT + K+ QQ K F + ++
Sbjct: 175 YAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQ-KGVSFPTHLS 233
Query: 250 SILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIA 284
+S +C+ ++K LLEPD LR S V W+A
Sbjct: 234 --ISADCQDLLKRLLEPDMILRPSIEEVSWHPWLA 266
Score = 173 bits (420), Expect = 2e-42
Identities = 96/238 (40%), Positives = 147/238 (61%), Gaps = 9/238 (3%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRY-KYFIFMRYMERGD 411
+A KVID P +F+++FLPRE++++ L H +++ + + + K + M E GD
Sbjct: 36 VAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKNIIQVYEMLESADGKICLVMELAEGGD 95
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
+ + VL G + E +A+ RQ+ AI+Y H +AHRD+KCEN LL N+KL+DFGF
Sbjct: 96 VFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQGF-NLKLTDFGF 154
Query: 472 ARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFED 531
A++ + K E+ S+TFCGS +Y APE+LQG P+ K DVWS+G+V+YVML ++PF+D
Sbjct: 155 AKV-LPKSHREL-SQTFCGSTAYAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCASLPFDD 212
Query: 532 KHI-KQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIA 588
I K L Q Q K F + +IS +C+ L+ +LEP+ R I ++ W+A
Sbjct: 213 TDIPKMLWQQQ--KGVSFPTHL--SISADCQDLLKRLLEPDMILRPSIEEVSWHPWLA 266
>BC014611-1|AAH14611.1| 273|Homo sapiens testis-specific serine
kinase 6 protein.
Length = 273
Score = 204 bits (499), Expect = 6e-52
Identities = 117/277 (42%), Positives = 166/277 (59%), Gaps = 13/277 (4%)
Query: 9 SEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFL 68
S + L GYKL + +GEG+Y+KV + +SK+ +K T+A K+++ +AP DFV KFL
Sbjct: 2 SGDKLLSELGYKLGRTIGEGSYSKVKVA--TSKK--YKGTVAIKVVDRRRAPPDFVNKFL 57
Query: 69 PREIDVLVRLNHPHLIHVHSIFQR-KTKYYIFMRYTENGDLLSYILKNGCVSENQARVWT 127
PRE+ +L + HPH++HV + K YI M DLL + +NG + QAR
Sbjct: 58 PRELSILRGVRHPHIVHVFEFIEVCNGKLYIVMEAAAT-DLLQAVQRNGRIPGVQARDLF 116
Query: 128 RQLALGLQYLHELEIAHRDIKCENVLLTANFN-VKLSDFGFSRFCVESDNQPVLSETYCG 186
Q+A ++YLH+ + HRD+KCENVLL+ + VKL+DFGF R ++ P LS TYCG
Sbjct: 117 AQIAGAVRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFGFGR---QAHGYPDLSTTYCG 173
Query: 187 SMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRS 246
S +YA+PE+L G PY PK D+WS+GVVL+VM+ MPFDD+ + L +Q K
Sbjct: 174 SAAYASPEVLLGIPYDPKKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQ---KRGVLY 230
Query: 247 RVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
LS CK ++ LL+ P R SA V + W+
Sbjct: 231 PEGLELSERCKALIAELLQFSPSARPSAGQVARNCWL 267
Score = 166 bits (404), Expect = 2e-40
Identities = 94/237 (39%), Positives = 138/237 (58%), Gaps = 9/237 (3%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQR-RYKYFIFMRYMERGD 411
+A KV+D AP DFV KFLPRE+ +L + HPH+VH + K +I M D
Sbjct: 38 VAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPHIVHVFEFIEVCNGKLYIVMEAAAT-D 96
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQN-VKLSDFG 470
LL+ V + G + QAR Q+A A++Y+H+ + HRD+KCENVLL+ ++ VKL+DFG
Sbjct: 97 LLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFG 156
Query: 471 FARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
F R ++ S T+CGS +Y +PE+L G PY PK DVWS+G+V+YVM+ MPF+
Sbjct: 157 FGRQA--HGYPDL-STTYCGSAAYASPEVLLGIPYDPKKYDVWSMGVVLYVMVTGCMPFD 213
Query: 531 DKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
D I L + Q K ++ +S+ CK LI +L+ + R + + W+
Sbjct: 214 DSDIAGLPRRQ--KRGVLYPEGLE-LSERCKALIAELLQFSPSARPSAGQVARNCWL 267
>AF329483-1|AAK48827.1| 273|Homo sapiens serine/threonine protein
kinase SSTK protein.
Length = 273
Score = 204 bits (499), Expect = 6e-52
Identities = 117/277 (42%), Positives = 166/277 (59%), Gaps = 13/277 (4%)
Query: 9 SEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFL 68
S + L GYKL + +GEG+Y+KV + +SK+ +K T+A K+++ +AP DFV KFL
Sbjct: 2 SGDKLLSELGYKLGRTIGEGSYSKVKVA--TSKK--YKGTVAIKVVDRRRAPPDFVNKFL 57
Query: 69 PREIDVLVRLNHPHLIHVHSIFQR-KTKYYIFMRYTENGDLLSYILKNGCVSENQARVWT 127
PRE+ +L + HPH++HV + K YI M DLL + +NG + QAR
Sbjct: 58 PRELSILRGVRHPHIVHVFEFIEVCNGKLYIVMEAAAT-DLLQAVQRNGRIPGVQARDLF 116
Query: 128 RQLALGLQYLHELEIAHRDIKCENVLLTANFN-VKLSDFGFSRFCVESDNQPVLSETYCG 186
Q+A ++YLH+ + HRD+KCENVLL+ + VKL+DFGF R ++ P LS TYCG
Sbjct: 117 AQIAGAVRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFGFGR---QAHGYPDLSTTYCG 173
Query: 187 SMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRS 246
S +YA+PE+L G PY PK D+WS+GVVL+VM+ MPFDD+ + L +Q K
Sbjct: 174 SAAYASPEVLLGIPYDPKKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQ---KRGVLY 230
Query: 247 RVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
LS CK ++ LL+ P R SA V + W+
Sbjct: 231 PEGLELSERCKALIAELLQFSPSARPSAGQVARNCWL 267
Score = 166 bits (404), Expect = 2e-40
Identities = 94/237 (39%), Positives = 138/237 (58%), Gaps = 9/237 (3%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQR-RYKYFIFMRYMERGD 411
+A KV+D AP DFV KFLPRE+ +L + HPH+VH + K +I M D
Sbjct: 38 VAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPHIVHVFEFIEVCNGKLYIVMEAAAT-D 96
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQN-VKLSDFG 470
LL+ V + G + QAR Q+A A++Y+H+ + HRD+KCENVLL+ ++ VKL+DFG
Sbjct: 97 LLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFG 156
Query: 471 FARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
F R ++ S T+CGS +Y +PE+L G PY PK DVWS+G+V+YVM+ MPF+
Sbjct: 157 FGRQA--HGYPDL-STTYCGSAAYASPEVLLGIPYDPKKYDVWSMGVVLYVMVTGCMPFD 213
Query: 531 DKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
D I L + Q K ++ +S+ CK LI +L+ + R + + W+
Sbjct: 214 DSDIAGLPRRQ--KRGVLYPEGLE-LSERCKALIAELLQFSPSARPSAGQVARNCWL 267
>AY461663-1|AAS17971.1| 328|Homo sapiens testis-specific serine
kinase 4 protein.
Length = 328
Score = 196 bits (477), Expect = 3e-49
Identities = 110/292 (37%), Positives = 164/292 (56%), Gaps = 24/292 (8%)
Query: 6 TTPSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVV 65
TT + + + GY++ K +G G+Y VY Y+ + K +A KII KA D++
Sbjct: 12 TTTAYHSLMDEYGYEVGKAIGHGSYGSVYEAFYTKQ----KVMVAVKIISKKKASDDYLN 67
Query: 66 KFLPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARV 125
KFLPREI V+ L H +LI+ + + ++ YI + + GD+L +I + G SE A
Sbjct: 68 KFLPREIQVMKVLRHKYLINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGK 127
Query: 126 WTRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPV------ 179
W QL LG+ YLH I HRD+K EN+LL NVK+SDFGF++ + NQPV
Sbjct: 128 WFSQLTLGIAYLHSKSIVHRDLKLENLLLDKWENVKISDFGFAK--MVPSNQPVGCSPSY 185
Query: 180 --------LSETYCGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMR 231
LS+TYCGS +YA PEILRG PY P +D WS+GV+L+ ++ +PFDDT ++
Sbjct: 186 RQVNCFSHLSQTYCGSFAYACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLK 245
Query: 232 KLYEQQMGKKYRFRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
KL + K+ F + +S ECK ++ +L R + +++ W+
Sbjct: 246 KLLRETQ-KEVTFPAN--HTISQECKNLILQMLR-QATKRATILDIIKDSWV 293
Score = 172 bits (418), Expect = 4e-42
Identities = 97/280 (34%), Positives = 156/280 (55%), Gaps = 22/280 (7%)
Query: 352 ILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
++A K+I A D++ KFLPREI+++ L H +L++ + + + +I + + GD
Sbjct: 50 MVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKYLINFYRAIESTSRVYIILELAQGGD 109
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
+LE++ + GA E A W QL L I Y+H I HRD+K EN+LL +NVK+SDFGF
Sbjct: 110 VLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKSIVHRDLKLENLLLDKWENVKISDFGF 169
Query: 472 ARMCVD----------KKLN--EIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVV 519
A+M +++N S+T+CGS +Y PEIL+G PY P +D WS+G+++
Sbjct: 170 AKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAYACPEILRGLPYNPFLSDTWSMGVIL 229
Query: 520 YVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIY 579
Y ++ +PF+D ++K+L + + K F + + TIS CK LI ML R I
Sbjct: 230 YTLVVAHLPFDDTNLKKLLR-ETQKEVTFPANH--TISQECKNLILQMLR-QATKRATIL 285
Query: 580 DIVNSEWIAMDSRLLEWTPQETLAYKKAREEKNKLHKTVE 619
DI+ W+ L++ P++ + E +LH T +
Sbjct: 286 DIIKDSWV------LKFQPEQPTHEIRLLEAMCQLHNTTK 319
>AK172841-1|BAD18805.1| 406|Homo sapiens protein ( Homo sapiens
cDNA FLJ24002 fis, clone KAIA4350, highly similar to
Homo sapiens serine/threonine protein kinase SSTK
(SSTK). ).
Length = 406
Score = 194 bits (473), Expect = 8e-49
Identities = 104/231 (45%), Positives = 148/231 (64%), Gaps = 10/231 (4%)
Query: 9 SEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFL 68
S + L GYKL + +GEG+Y+KV + +SK+ +K T+A K+++ +AP DFV KFL
Sbjct: 2 SGDKLLSELGYKLGRTIGEGSYSKVKVA--TSKK--YKGTVAIKVVDRRRAPPDFVNKFL 57
Query: 69 PREIDVLVRLNHPHLIHVHSIFQR-KTKYYIFMRYTENGDLLSYILKNGCVSENQARVWT 127
PRE+ +L + HPH++HV + K YI M DLL + +NG + QAR
Sbjct: 58 PRELSILRGVRHPHIVHVFEFIEVCNGKLYIVMEAAAT-DLLQAVQRNGRIPGVQARDLF 116
Query: 128 RQLALGLQYLHELEIAHRDIKCENVLLTANFN-VKLSDFGFSRFCVESDNQPVLSETYCG 186
Q+A ++YLH+ + HRD+KCENVLL+ + VKL+DFGF R ++ P LS TYCG
Sbjct: 117 AQIAGAVRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFGFGR---QAHGYPDLSTTYCG 173
Query: 187 SMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQ 237
S +YA+PE+L G PY PK D+WS+GVVL+VM+ MPFDD+ + L +Q
Sbjct: 174 SAAYASPEVLLGIPYDPKKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQ 224
Score = 163 bits (395), Expect = 2e-39
Identities = 91/214 (42%), Positives = 129/214 (60%), Gaps = 9/214 (4%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQR-RYKYFIFMRYMERGD 411
+A KV+D AP DFV KFLPRE+ +L + HPH+VH + K +I M D
Sbjct: 38 VAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPHIVHVFEFIEVCNGKLYIVMEAAAT-D 96
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQN-VKLSDFG 470
LL+ V + G + QAR Q+A A++Y+H+ + HRD+KCENVLL+ ++ VKL+DFG
Sbjct: 97 LLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFG 156
Query: 471 FARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
F R ++ S T+CGS +Y +PE+L G PY PK DVWS+G+V+YVM+ MPF+
Sbjct: 157 FGRQA--HGYPDL-STTYCGSAAYASPEVLLGIPYDPKKYDVWSMGVVLYVMVTGCMPFD 213
Query: 531 DKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLI 564
D I L + Q K ++ +S+ CK LI
Sbjct: 214 DSDIAGLPRRQ--KRGVLYPEGLE-LSERCKALI 244
>AK131042-1|BAC85482.1| 338|Homo sapiens protein ( Homo sapiens
cDNA FLJ29008 fis, clone TST06032. ).
Length = 338
Score = 184 bits (448), Expect = 9e-46
Identities = 110/302 (36%), Positives = 164/302 (54%), Gaps = 34/302 (11%)
Query: 6 TTPSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVV 65
TT + + + GY++ K +G G+Y VY Y+ + K +A KII KA D++
Sbjct: 12 TTTAYHSLMDEYGYEVGKAIGHGSYGSVYEAFYTKQ----KVMVAVKIISKKKASDDYLN 67
Query: 66 KFLPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARV 125
KFLPREI V+ L H +LI+ + + ++ YI + + GD+L +I + G SE A
Sbjct: 68 KFLPREIQVMKVLRHKYLINFYRAIESTSRVYIILELAQGGDVLEWIRRYGACSEPLAGK 127
Query: 126 WTRQLALGLQYLHELEIAH----------RDIKCENVLLTANFNVKLSDFGFSRFCVESD 175
W QL LG+ YLH I H RD+K EN+LL NVK+SDFGF++ +
Sbjct: 128 WFSQLTLGIAYLHSKSIVHRLMPSLSAAGRDLKLENLLLDKWENVKISDFGFAK--MVPS 185
Query: 176 NQPV--------------LSETYCGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNK 221
NQPV LS+TYCGS +YA PEILRG PY P +D WS+GV+L+ ++
Sbjct: 186 NQPVGCSPSYRQVNCFSHLSQTYCGSFAYACPEILRGLPYNPFLSDTWSMGVILYTLVVA 245
Query: 222 SMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSE 281
+PFDDT ++KL + K+ F + +S ECK ++ +L R + +++
Sbjct: 246 HLPFDDTNLKKLLRETQ-KEVTFPAN--HTISQECKNLILQMLR-QATKRATILDIIKDS 301
Query: 282 WI 283
W+
Sbjct: 302 WV 303
Score = 160 bits (389), Expect = 1e-38
Identities = 97/290 (33%), Positives = 156/290 (53%), Gaps = 32/290 (11%)
Query: 352 ILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
++A K+I A D++ KFLPREI+++ L H +L++ + + + +I + + GD
Sbjct: 50 MVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKYLINFYRAIESTSRVYIILELAQGGD 109
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAH----------RDIKCENVLLTAN 461
+LE++ + GA E A W QL L I Y+H I H RD+K EN+LL
Sbjct: 110 VLEWIRRYGACSEPLAGKWFSQLTLGIAYLHSKSIVHRLMPSLSAAGRDLKLENLLLDKW 169
Query: 462 QNVKLSDFGFARMCVD----------KKLN--EIRSETFCGSLSYTAPEILQGTPYLPKP 509
+NVK+SDFGFA+M +++N S+T+CGS +Y PEIL+G PY P
Sbjct: 170 ENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAYACPEILRGLPYNPFL 229
Query: 510 TDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLE 569
+D WS+G+++Y ++ +PF+D ++K+L + + K F + + TIS CK LI ML
Sbjct: 230 SDTWSMGVILYTLVVAHLPFDDTNLKKLLR-ETQKEVTFPANH--TISQECKNLILQMLR 286
Query: 570 PNHQNRLKIYDIVNSEWIAMDSRLLEWTPQETLAYKKAREEKNKLHKTVE 619
R I DI+ W+ L++ P++ + E +LH T +
Sbjct: 287 -QATKRATILDIIKDSWV------LKFQPEQPTHEIRLLEAMCQLHNTTK 329
>BC038504-1|AAH38504.1| 783|Homo sapiens SNF1-like kinase protein.
Length = 783
Score = 173 bits (422), Expect = 1e-42
Identities = 88/265 (33%), Positives = 150/265 (56%), Gaps = 13/265 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y + + +G+G +A V L + K+ +A KII+ + + K RE+ ++ L
Sbjct: 27 YDIERTLGKGNFAVVKLARHRVT----KTQVAIKIIDKTRLDSSNLEKIY-REVQLMKLL 81
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHPH+I ++ + + K YI + +NG++ Y+ NG +SEN+AR Q+ ++Y H
Sbjct: 82 NHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCH 141
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
+ I HRD+K EN+LL N ++KL+DFGF F +P+ T+CGS YAAPE+ G
Sbjct: 142 DHHIVHRDLKTENLLLDGNMDIKLADFGFGNF--YKSGEPL--STWCGSPPYAAPEVFEG 197
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
K Y D+WSLGVVL+V++ S+PFD + L ++ + ++ R+ +S +C++
Sbjct: 198 KEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRF----RIPFFMSQDCES 253
Query: 259 VVKHLLEPDPGLRHSATNVLDSEWI 283
+++ +L DP R + + W+
Sbjct: 254 LIRRMLVVDPARRITIAQIRQHRWM 278
Score = 142 bits (343), Expect = 5e-33
Identities = 74/235 (31%), Positives = 132/235 (56%), Gaps = 9/235 (3%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A K+ID + ++K RE++++ L+HPH++ + + + + +I + + G++
Sbjct: 53 VAIKIIDKTRLDSSNLEKIY-REVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEM 111
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
+++ G + E++AR Q+ A++Y H+ I HRD+K EN+LL N ++KL+DFGF
Sbjct: 112 FDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFG 171
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
K E S T+CGS Y APE+ +G Y D+WSLG+V+YV++ ++PF+
Sbjct: 172 NF---YKSGEPLS-TWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGP 227
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
++ L Q + +FR + +S +C+ LI ML + R+ I I W+
Sbjct: 228 NLPTLRQRVL--EGRFRIPFF--MSQDCESLIRRMLVVDPARRITIAQIRQHRWM 278
>AK131076-1|BAC85126.1| 764|Homo sapiens FLJ00263 protein protein.
Length = 764
Score = 173 bits (422), Expect = 1e-42
Identities = 88/265 (33%), Positives = 150/265 (56%), Gaps = 13/265 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y + + +G+G +A V L + K+ +A KII+ + + K RE+ ++ L
Sbjct: 8 YDIERTLGKGNFAVVKLARHRVT----KTQVAIKIIDKTRLDSSNLEKIY-REVQLMKLL 62
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHPH+I ++ + + K YI + +NG++ Y+ NG +SEN+AR Q+ ++Y H
Sbjct: 63 NHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCH 122
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
+ I HRD+K EN+LL N ++KL+DFGF F +P+ T+CGS YAAPE+ G
Sbjct: 123 DHHIVHRDLKTENLLLDGNMDIKLADFGFGNF--YKSGEPL--STWCGSPPYAAPEVFEG 178
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
K Y D+WSLGVVL+V++ S+PFD + L ++ + ++ R+ +S +C++
Sbjct: 179 KEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRF----RIPFFMSQDCES 234
Query: 259 VVKHLLEPDPGLRHSATNVLDSEWI 283
+++ +L DP R + + W+
Sbjct: 235 LIRRMLVVDPARRITIAQIRQHRWM 259
Score = 142 bits (343), Expect = 5e-33
Identities = 74/235 (31%), Positives = 132/235 (56%), Gaps = 9/235 (3%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A K+ID + ++K RE++++ L+HPH++ + + + + +I + + G++
Sbjct: 34 VAIKIIDKTRLDSSNLEKIY-REVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEM 92
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
+++ G + E++AR Q+ A++Y H+ I HRD+K EN+LL N ++KL+DFGF
Sbjct: 93 FDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFG 152
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
K E S T+CGS Y APE+ +G Y D+WSLG+V+YV++ ++PF+
Sbjct: 153 NF---YKSGEPLS-TWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGP 208
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
++ L Q + +FR + +S +C+ LI ML + R+ I I W+
Sbjct: 209 NLPTLRQRVL--EGRFRIPFF--MSQDCESLIRRMLVVDPARRITIAQIRQHRWM 259
>AB047786-1|BAD74070.1| 783|Homo sapiens serine/threonine protein
kinase protein.
Length = 783
Score = 173 bits (422), Expect = 1e-42
Identities = 88/265 (33%), Positives = 150/265 (56%), Gaps = 13/265 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y + + +G+G +A V L + K+ +A KII+ + + K RE+ ++ L
Sbjct: 27 YDIERTLGKGNFAVVKLARHRVT----KTQVAIKIIDKTRLDSSNLEKIY-REVQLMKLL 81
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHPH+I ++ + + K YI + +NG++ Y+ NG +SEN+AR Q+ ++Y H
Sbjct: 82 NHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCH 141
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
+ I HRD+K EN+LL N ++KL+DFGF F +P+ T+CGS YAAPE+ G
Sbjct: 142 DHHIVHRDLKTENLLLDGNMDIKLADFGFGNF--YKSGEPL--STWCGSPPYAAPEVFEG 197
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
K Y D+WSLGVVL+V++ S+PFD + L ++ + ++ R+ +S +C++
Sbjct: 198 KEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRF----RIPFFMSQDCES 253
Query: 259 VVKHLLEPDPGLRHSATNVLDSEWI 283
+++ +L DP R + + W+
Sbjct: 254 LIRRMLVVDPARRITIAQIRQHRWM 278
Score = 142 bits (343), Expect = 5e-33
Identities = 74/235 (31%), Positives = 132/235 (56%), Gaps = 9/235 (3%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A K+ID + ++K RE++++ L+HPH++ + + + + +I + + G++
Sbjct: 53 VAIKIIDKTRLDSSNLEKIY-REVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEM 111
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
+++ G + E++AR Q+ A++Y H+ I HRD+K EN+LL N ++KL+DFGF
Sbjct: 112 FDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFG 171
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
K E S T+CGS Y APE+ +G Y D+WSLG+V+YV++ ++PF+
Sbjct: 172 NF---YKSGEPLS-TWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGP 227
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
++ L Q + +FR + +S +C+ LI ML + R+ I I W+
Sbjct: 228 NLPTLRQRVL--EGRFRIPFF--MSQDCESLIRRMLVVDPARRITIAQIRQHRWM 278
>X97630-1|CAA66229.1| 745|Homo sapiens serine/threonine protein
kinase protein.
Length = 745
Score = 173 bits (420), Expect = 2e-42
Identities = 88/267 (32%), Positives = 153/267 (57%), Gaps = 17/267 (6%)
Query: 19 YKLTKFVGEGAYAKVYLTEY--SSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLV 76
Y+L K +G+G +AKV L + + KE +A KII+ + + K RE+ ++
Sbjct: 20 YRLLKTIGKGNFAKVKLARHILTGKE------VAVKIIDKTQLNSSSLQKLF-REVRIMK 72
Query: 77 RLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQY 136
LNHP+++ + + + + Y+ M Y G++ Y++ +G + E +AR RQ+ +QY
Sbjct: 73 VLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQY 132
Query: 137 LHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEIL 196
H+ I HRD+K EN+LL A+ N+K++DFGFS + +T+CGS YAAPE+
Sbjct: 133 CHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK----LDTFCGSPPYAAPELF 188
Query: 197 RGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLEC 256
+GK Y D+WSLGV+L+ +++ S+PFD +++L E+ + KY R+ +S +C
Sbjct: 189 QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY----RIPFYMSTDC 244
Query: 257 KTVVKHLLEPDPGLRHSATNVLDSEWI 283
+ ++K L +P R + ++ W+
Sbjct: 245 ENLLKKFLILNPSKRGTLEQIMKDRWM 271
Score = 148 bits (359), Expect = 5e-35
Identities = 75/236 (31%), Positives = 135/236 (57%), Gaps = 11/236 (4%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A K+ID + ++K RE+ ++ L+HP++V + + ++ M Y G++
Sbjct: 46 VAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEV 104
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
++++ G ++E +AR RQ+ A+QY H+ I HRD+K EN+LL A+ N+K++DFGF+
Sbjct: 105 FDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFS 164
Query: 473 -RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFED 531
KL +TFCGS Y APE+ QG Y DVWSLG+++Y +++ ++PF+
Sbjct: 165 NEFTFGNKL-----DTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG 219
Query: 532 KHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+++K+L + + K+R + +S +C+ L+ L N R + I+ W+
Sbjct: 220 QNLKELRERVL--RGKYRIPFY--MSTDCENLLKKFLILNPSKRGTLEQIMKDRWM 271
>BT007342-1|AAP36006.1| 755|Homo sapiens MAP/microtubule
affinity-regulating kinase 2 protein.
Length = 755
Score = 173 bits (420), Expect = 2e-42
Identities = 88/267 (32%), Positives = 153/267 (57%), Gaps = 17/267 (6%)
Query: 19 YKLTKFVGEGAYAKVYLTEY--SSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLV 76
Y+L K +G+G +AKV L + + KE +A KII+ + + K RE+ ++
Sbjct: 20 YRLLKTIGKGNFAKVKLARHILTGKE------VAVKIIDKTQLNSSSLQKLF-REVRIMK 72
Query: 77 RLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQY 136
LNHP+++ + + + + Y+ M Y G++ Y++ +G + E +AR RQ+ +QY
Sbjct: 73 VLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQY 132
Query: 137 LHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEIL 196
H+ I HRD+K EN+LL A+ N+K++DFGFS + +T+CGS YAAPE+
Sbjct: 133 CHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK----LDTFCGSPPYAAPELF 188
Query: 197 RGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLEC 256
+GK Y D+WSLGV+L+ +++ S+PFD +++L E+ + KY R+ +S +C
Sbjct: 189 QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY----RIPFYMSTDC 244
Query: 257 KTVVKHLLEPDPGLRHSATNVLDSEWI 283
+ ++K L +P R + ++ W+
Sbjct: 245 ENLLKKFLILNPSKRGTLEQIMKDRWM 271
Score = 148 bits (359), Expect = 5e-35
Identities = 75/236 (31%), Positives = 135/236 (57%), Gaps = 11/236 (4%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A K+ID + ++K RE+ ++ L+HP++V + + ++ M Y G++
Sbjct: 46 VAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEV 104
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
++++ G ++E +AR RQ+ A+QY H+ I HRD+K EN+LL A+ N+K++DFGF+
Sbjct: 105 FDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFS 164
Query: 473 -RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFED 531
KL +TFCGS Y APE+ QG Y DVWSLG+++Y +++ ++PF+
Sbjct: 165 NEFTFGNKL-----DTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG 219
Query: 532 KHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+++K+L + + K+R + +S +C+ L+ L N R + I+ W+
Sbjct: 220 QNLKELRERVL--RGKYRIPFY--MSTDCENLLKKFLILNPSKRGTLEQIMKDRWM 271
>BC084540-1|AAH84540.1| 724|Homo sapiens MAP/microtubule
affinity-regulating kinase 2 protein.
Length = 724
Score = 173 bits (420), Expect = 2e-42
Identities = 88/267 (32%), Positives = 153/267 (57%), Gaps = 17/267 (6%)
Query: 19 YKLTKFVGEGAYAKVYLTEY--SSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLV 76
Y+L K +G+G +AKV L + + KE +A KII+ + + K RE+ ++
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKE------VAVKIIDKTQLNSSSLQKLF-REVRIMK 105
Query: 77 RLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQY 136
LNHP+++ + + + + Y+ M Y G++ Y++ +G + E +AR RQ+ +QY
Sbjct: 106 VLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQY 165
Query: 137 LHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEIL 196
H+ I HRD+K EN+LL A+ N+K++DFGFS + +T+CGS YAAPE+
Sbjct: 166 CHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK----LDTFCGSPPYAAPELF 221
Query: 197 RGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLEC 256
+GK Y D+WSLGV+L+ +++ S+PFD +++L E+ + KY R+ +S +C
Sbjct: 222 QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY----RIPFYMSTDC 277
Query: 257 KTVVKHLLEPDPGLRHSATNVLDSEWI 283
+ ++K L +P R + ++ W+
Sbjct: 278 ENLLKKFLILNPSKRGTLEQIMKDRWM 304
Score = 148 bits (359), Expect = 5e-35
Identities = 75/236 (31%), Positives = 135/236 (57%), Gaps = 11/236 (4%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A K+ID + ++K RE+ ++ L+HP++V + + ++ M Y G++
Sbjct: 79 VAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEV 137
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
++++ G ++E +AR RQ+ A+QY H+ I HRD+K EN+LL A+ N+K++DFGF+
Sbjct: 138 FDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFS 197
Query: 473 -RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFED 531
KL +TFCGS Y APE+ QG Y DVWSLG+++Y +++ ++PF+
Sbjct: 198 NEFTFGNKL-----DTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG 252
Query: 532 KHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+++K+L + + K+R + +S +C+ L+ L N R + I+ W+
Sbjct: 253 QNLKELRERVL--RGKYRIPFY--MSTDCENLLKKFLILNPSKRGTLEQIMKDRWM 304
>BC008771-1|AAH08771.2| 778|Homo sapiens MARK2 protein protein.
Length = 778
Score = 173 bits (420), Expect = 2e-42
Identities = 88/267 (32%), Positives = 153/267 (57%), Gaps = 17/267 (6%)
Query: 19 YKLTKFVGEGAYAKVYLTEY--SSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLV 76
Y+L K +G+G +AKV L + + KE +A KII+ + + K RE+ ++
Sbjct: 43 YRLLKTIGKGNFAKVKLARHILTGKE------VAVKIIDKTQLNSSSLQKLF-REVRIMK 95
Query: 77 RLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQY 136
LNHP+++ + + + + Y+ M Y G++ Y++ +G + E +AR RQ+ +QY
Sbjct: 96 VLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQY 155
Query: 137 LHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEIL 196
H+ I HRD+K EN+LL A+ N+K++DFGFS + +T+CGS YAAPE+
Sbjct: 156 CHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK----LDTFCGSPPYAAPELF 211
Query: 197 RGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLEC 256
+GK Y D+WSLGV+L+ +++ S+PFD +++L E+ + KY R+ +S +C
Sbjct: 212 QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY----RIPFYMSTDC 267
Query: 257 KTVVKHLLEPDPGLRHSATNVLDSEWI 283
+ ++K L +P R + ++ W+
Sbjct: 268 ENLLKKFLILNPSKRGTLEQIMKDRWM 294
Score = 148 bits (359), Expect = 5e-35
Identities = 75/236 (31%), Positives = 135/236 (57%), Gaps = 11/236 (4%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A K+ID + ++K RE+ ++ L+HP++V + + ++ M Y G++
Sbjct: 69 VAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEV 127
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
++++ G ++E +AR RQ+ A+QY H+ I HRD+K EN+LL A+ N+K++DFGF+
Sbjct: 128 FDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFS 187
Query: 473 -RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFED 531
KL +TFCGS Y APE+ QG Y DVWSLG+++Y +++ ++PF+
Sbjct: 188 NEFTFGNKL-----DTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG 242
Query: 532 KHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+++K+L + + K+R + +S +C+ L+ L N R + I+ W+
Sbjct: 243 QNLKELRERVL--RGKYRIPFY--MSTDCENLLKKFLILNPSKRGTLEQIMKDRWM 294
>AF387638-1|AAK82368.1| 691|Homo sapiens Ser/Thr protein kinase
PAR-1Balpha protein.
Length = 691
Score = 173 bits (420), Expect = 2e-42
Identities = 88/267 (32%), Positives = 153/267 (57%), Gaps = 17/267 (6%)
Query: 19 YKLTKFVGEGAYAKVYLTEY--SSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLV 76
Y+L K +G+G +AKV L + + KE +A KII+ + + K RE+ ++
Sbjct: 20 YRLLKTIGKGNFAKVKLARHILTGKE------VAVKIIDKTQLNSSSLQKLF-REVRIMK 72
Query: 77 RLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQY 136
LNHP+++ + + + + Y+ M Y G++ Y++ +G + E +AR RQ+ +QY
Sbjct: 73 VLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQY 132
Query: 137 LHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEIL 196
H+ I HRD+K EN+LL A+ N+K++DFGFS + +T+CGS YAAPE+
Sbjct: 133 CHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK----LDTFCGSPPYAAPELF 188
Query: 197 RGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLEC 256
+GK Y D+WSLGV+L+ +++ S+PFD +++L E+ + KY R+ +S +C
Sbjct: 189 QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY----RIPFYMSTDC 244
Query: 257 KTVVKHLLEPDPGLRHSATNVLDSEWI 283
+ ++K L +P R + ++ W+
Sbjct: 245 ENLLKKFLILNPSKRGTLEQIMKDRWM 271
Score = 148 bits (359), Expect = 5e-35
Identities = 75/236 (31%), Positives = 135/236 (57%), Gaps = 11/236 (4%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A K+ID + ++K RE+ ++ L+HP++V + + ++ M Y G++
Sbjct: 46 VAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEV 104
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
++++ G ++E +AR RQ+ A+QY H+ I HRD+K EN+LL A+ N+K++DFGF+
Sbjct: 105 FDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFS 164
Query: 473 -RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFED 531
KL +TFCGS Y APE+ QG Y DVWSLG+++Y +++ ++PF+
Sbjct: 165 NEFTFGNKL-----DTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG 219
Query: 532 KHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+++K+L + + K+R + +S +C+ L+ L N R + I+ W+
Sbjct: 220 QNLKELRERVL--RGKYRIPFY--MSTDCENLLKKFLILNPSKRGTLEQIMKDRWM 271
>AB188493-1|BAD37141.1| 719|Homo sapiens serine/threonine kinase
protein.
Length = 719
Score = 173 bits (420), Expect = 2e-42
Identities = 88/267 (32%), Positives = 153/267 (57%), Gaps = 17/267 (6%)
Query: 19 YKLTKFVGEGAYAKVYLTEY--SSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLV 76
Y+L K +G+G +AKV L + + KE +A KII+ + + K RE+ ++
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKE------VAVKIIDKTQLNSSSLQKLF-REVRIMK 105
Query: 77 RLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQY 136
LNHP+++ + + + + Y+ M Y G++ Y++ +G + E +AR RQ+ +QY
Sbjct: 106 VLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQY 165
Query: 137 LHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEIL 196
H+ I HRD+K EN+LL A+ N+K++DFGFS + +T+CGS YAAPE+
Sbjct: 166 CHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK----LDTFCGSPPYAAPELF 221
Query: 197 RGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLEC 256
+GK Y D+WSLGV+L+ +++ S+PFD +++L E+ + KY R+ +S +C
Sbjct: 222 QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY----RIPFYMSTDC 277
Query: 257 KTVVKHLLEPDPGLRHSATNVLDSEWI 283
+ ++K L +P R + ++ W+
Sbjct: 278 ENLLKKFLILNPSKRGTLEQIMKDRWM 304
Score = 148 bits (359), Expect = 5e-35
Identities = 75/236 (31%), Positives = 135/236 (57%), Gaps = 11/236 (4%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A K+ID + ++K RE+ ++ L+HP++V + + ++ M Y G++
Sbjct: 79 VAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEV 137
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
++++ G ++E +AR RQ+ A+QY H+ I HRD+K EN+LL A+ N+K++DFGF+
Sbjct: 138 FDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFS 197
Query: 473 -RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFED 531
KL +TFCGS Y APE+ QG Y DVWSLG+++Y +++ ++PF+
Sbjct: 198 NEFTFGNKL-----DTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG 252
Query: 532 KHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+++K+L + + K+R + +S +C+ L+ L N R + I+ W+
Sbjct: 253 QNLKELRERVL--RGKYRIPFY--MSTDCENLLKKFLILNPSKRGTLEQIMKDRWM 304
>U64205-1|AAC15093.1| 729|Homo sapiens Cdc25C associated protein
kinase C-TAK1 protein.
Length = 729
Score = 172 bits (418), Expect = 4e-42
Identities = 89/266 (33%), Positives = 151/266 (56%), Gaps = 15/266 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L K +G+G +AKV L + +A KII+ + + K RE+ ++ L
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGRE----VAIKIIDKTQLNPTSLQKLF-REVRIMKIL 110
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP+++ + + + + Y+ M Y G++ Y++ +G + E +AR RQ+ +QY H
Sbjct: 111 NHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCH 170
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFS-RFCVESDNQPVLSETYCGSMSYAAPEILR 197
+ I HRD+K EN+LL A+ N+K++DFGFS F V +T+CGS YAAPE+ +
Sbjct: 171 QKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGK-----LDTFCGSPPYAAPELFQ 225
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECK 257
GK Y D+WSLGV+L+ +++ S+PFD +++L E+ + KY R+ +S +C+
Sbjct: 226 GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY----RIPFYMSTDCE 281
Query: 258 TVVKHLLEPDPGLRHSATNVLDSEWI 283
++K L +P R + ++ WI
Sbjct: 282 NLLKRFLVLNPIKRGTLEQIMKDRWI 307
Score = 151 bits (367), Expect = 6e-36
Identities = 80/237 (33%), Positives = 136/237 (57%), Gaps = 13/237 (5%)
Query: 353 LACKVID-TSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
+A K+ID T P K F RE+ ++ L+HP++V + + ++ M Y G+
Sbjct: 82 VAIKIIDKTQLNPTSLQKLF--REVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGE 139
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
+ ++++ G ++E +AR RQ+ A+QY H+ I HRD+K EN+LL A+ N+K++DFGF
Sbjct: 140 VFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGF 199
Query: 472 A-RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
+ V KL +TFCGS Y APE+ QG Y DVWSLG+++Y +++ ++PF+
Sbjct: 200 SNEFTVGGKL-----DTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFD 254
Query: 531 DKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+++K+L + + K+R + +S +C+ L+ L N R + I+ WI
Sbjct: 255 GQNLKELRERVL--RGKYRIPFY--MSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307
>BC024773-1|AAH24773.1| 729|Homo sapiens MAP/microtubule
affinity-regulating kinase 3 protein.
Length = 729
Score = 172 bits (418), Expect = 4e-42
Identities = 89/266 (33%), Positives = 151/266 (56%), Gaps = 15/266 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L K +G+G +AKV L + +A KII+ + + K RE+ ++ L
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGRE----VAIKIIDKTQLNPTSLQKLF-REVRIMKIL 110
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP+++ + + + + Y+ M Y G++ Y++ +G + E +AR RQ+ +QY H
Sbjct: 111 NHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCH 170
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFS-RFCVESDNQPVLSETYCGSMSYAAPEILR 197
+ I HRD+K EN+LL A+ N+K++DFGFS F V +T+CGS YAAPE+ +
Sbjct: 171 QKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGK-----LDTFCGSPPYAAPELFQ 225
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECK 257
GK Y D+WSLGV+L+ +++ S+PFD +++L E+ + KY R+ +S +C+
Sbjct: 226 GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY----RIPFYMSTDCE 281
Query: 258 TVVKHLLEPDPGLRHSATNVLDSEWI 283
++K L +P R + ++ WI
Sbjct: 282 NLLKRFLVLNPIKRGTLEQIMKDRWI 307
Score = 151 bits (367), Expect = 6e-36
Identities = 80/237 (33%), Positives = 136/237 (57%), Gaps = 13/237 (5%)
Query: 353 LACKVID-TSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
+A K+ID T P K F RE+ ++ L+HP++V + + ++ M Y G+
Sbjct: 82 VAIKIIDKTQLNPTSLQKLF--REVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGE 139
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
+ ++++ G ++E +AR RQ+ A+QY H+ I HRD+K EN+LL A+ N+K++DFGF
Sbjct: 140 VFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGF 199
Query: 472 A-RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
+ V KL +TFCGS Y APE+ QG Y DVWSLG+++Y +++ ++PF+
Sbjct: 200 SNEFTVGGKL-----DTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFD 254
Query: 531 DKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+++K+L + + K+R + +S +C+ L+ L N R + I+ WI
Sbjct: 255 GQNLKELRERVL--RGKYRIPFY--MSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307
>AF387637-1|AAK82367.1| 744|Homo sapiens Ser/Thr protein kinase
PAR-1A protein.
Length = 744
Score = 172 bits (418), Expect = 4e-42
Identities = 89/266 (33%), Positives = 151/266 (56%), Gaps = 15/266 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L K +G+G +AKV L + +A KII+ + + K RE+ ++ L
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGRE----VAIKIIDKTQLNPTSLQKLF-REVRIMKIL 110
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP+++ + + + + Y+ M Y G++ Y++ +G + E +AR RQ+ +QY H
Sbjct: 111 NHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCH 170
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFS-RFCVESDNQPVLSETYCGSMSYAAPEILR 197
+ I HRD+K EN+LL A+ N+K++DFGFS F V +T+CGS YAAPE+ +
Sbjct: 171 QKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGK-----LDTFCGSPPYAAPELFQ 225
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECK 257
GK Y D+WSLGV+L+ +++ S+PFD +++L E+ + KY R+ +S +C+
Sbjct: 226 GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY----RIPFYMSTDCE 281
Query: 258 TVVKHLLEPDPGLRHSATNVLDSEWI 283
++K L +P R + ++ WI
Sbjct: 282 NLLKRFLVLNPIKRGTLEQIMKDRWI 307
Score = 151 bits (367), Expect = 6e-36
Identities = 80/237 (33%), Positives = 136/237 (57%), Gaps = 13/237 (5%)
Query: 353 LACKVID-TSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
+A K+ID T P K F RE+ ++ L+HP++V + + ++ M Y G+
Sbjct: 82 VAIKIIDKTQLNPTSLQKLF--REVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGE 139
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
+ ++++ G ++E +AR RQ+ A+QY H+ I HRD+K EN+LL A+ N+K++DFGF
Sbjct: 140 VFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGF 199
Query: 472 A-RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
+ V KL +TFCGS Y APE+ QG Y DVWSLG+++Y +++ ++PF+
Sbjct: 200 SNEFTVGGKL-----DTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFD 254
Query: 531 DKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+++K+L + + K+R + +S +C+ L+ L N R + I+ WI
Sbjct: 255 GQNLKELRERVL--RGKYRIPFY--MSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307
>BC114478-1|AAI14479.1| 795|Homo sapiens MARK1 protein protein.
Length = 795
Score = 171 bits (417), Expect = 5e-42
Identities = 89/266 (33%), Positives = 152/266 (57%), Gaps = 15/266 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L K +G+G +AKV L + +A KII+ + + K RE+ ++ L
Sbjct: 60 YRLQKTIGKGNFAKVKLARHVLTGRE----VAVKIIDKTQLNPTSLQKLF-REVRIMKIL 114
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP+++ + + + + Y+ M Y G++ Y++ +G + E +AR RQ+ +QY H
Sbjct: 115 NHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 174
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFS-RFCVESDNQPVLSETYCGSMSYAAPEILR 197
+ I HRD+K EN+LL + N+K++DFGFS F V + +T+CGS YAAPE+ +
Sbjct: 175 QKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNK-----LDTFCGSPPYAAPELFQ 229
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECK 257
GK Y D+WSLGV+L+ +++ S+PFD +++L E+ + KY R+ +S +C+
Sbjct: 230 GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY----RIPFYMSTDCE 285
Query: 258 TVVKHLLEPDPGLRHSATNVLDSEWI 283
++K LL +P R S ++ W+
Sbjct: 286 NLLKKLLVLNPIKRGSLEQIMKDRWM 311
Score = 150 bits (363), Expect = 2e-35
Identities = 78/237 (32%), Positives = 136/237 (57%), Gaps = 13/237 (5%)
Query: 353 LACKVID-TSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
+A K+ID T P K F RE+ ++ L+HP++V + + ++ M Y G+
Sbjct: 86 VAVKIIDKTQLNPTSLQKLF--REVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGE 143
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
+ ++++ G ++E +AR RQ+ A+QY H+ I HRD+K EN+LL + N+K++DFGF
Sbjct: 144 VFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGF 203
Query: 472 A-RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
+ V KL +TFCGS Y APE+ QG Y DVWSLG+++Y +++ ++PF+
Sbjct: 204 SNEFTVGNKL-----DTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFD 258
Query: 531 DKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+++K+L + + K+R + +S +C+ L+ +L N R + I+ W+
Sbjct: 259 GQNLKELRERVL--RGKYRIPFY--MSTDCENLLKKLLVLNPIKRGSLEQIMKDRWM 311
>BC113869-1|AAI13870.1| 795|Homo sapiens MARK1 protein protein.
Length = 795
Score = 171 bits (417), Expect = 5e-42
Identities = 89/266 (33%), Positives = 152/266 (57%), Gaps = 15/266 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L K +G+G +AKV L + +A KII+ + + K RE+ ++ L
Sbjct: 60 YRLQKTIGKGNFAKVKLARHVLTGRE----VAVKIIDKTQLNPTSLQKLF-REVRIMKIL 114
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP+++ + + + + Y+ M Y G++ Y++ +G + E +AR RQ+ +QY H
Sbjct: 115 NHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 174
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFS-RFCVESDNQPVLSETYCGSMSYAAPEILR 197
+ I HRD+K EN+LL + N+K++DFGFS F V + +T+CGS YAAPE+ +
Sbjct: 175 QKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNK-----LDTFCGSPPYAAPELFQ 229
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECK 257
GK Y D+WSLGV+L+ +++ S+PFD +++L E+ + KY R+ +S +C+
Sbjct: 230 GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY----RIPFYMSTDCE 285
Query: 258 TVVKHLLEPDPGLRHSATNVLDSEWI 283
++K LL +P R S ++ W+
Sbjct: 286 NLLKKLLVLNPIKRGSLEQIMKDRWM 311
Score = 150 bits (363), Expect = 2e-35
Identities = 78/237 (32%), Positives = 136/237 (57%), Gaps = 13/237 (5%)
Query: 353 LACKVID-TSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
+A K+ID T P K F RE+ ++ L+HP++V + + ++ M Y G+
Sbjct: 86 VAVKIIDKTQLNPTSLQKLF--REVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGE 143
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
+ ++++ G ++E +AR RQ+ A+QY H+ I HRD+K EN+LL + N+K++DFGF
Sbjct: 144 VFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGF 203
Query: 472 A-RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
+ V KL +TFCGS Y APE+ QG Y DVWSLG+++Y +++ ++PF+
Sbjct: 204 SNEFTVGNKL-----DTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFD 258
Query: 531 DKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+++K+L + + K+R + +S +C+ L+ +L N R + I+ W+
Sbjct: 259 GQNLKELRERVL--RGKYRIPFY--MSTDCENLLKKLLVLNPIKRGSLEQIMKDRWM 311
>AL592406-3|CAH72463.1| 795|Homo sapiens MAP/microtubule
affinity-regulating kinase 1 protein.
Length = 795
Score = 171 bits (417), Expect = 5e-42
Identities = 89/266 (33%), Positives = 152/266 (57%), Gaps = 15/266 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L K +G+G +AKV L + +A KII+ + + K RE+ ++ L
Sbjct: 60 YRLQKTIGKGNFAKVKLARHVLTGRE----VAVKIIDKTQLNPTSLQKLF-REVRIMKIL 114
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP+++ + + + + Y+ M Y G++ Y++ +G + E +AR RQ+ +QY H
Sbjct: 115 NHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 174
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFS-RFCVESDNQPVLSETYCGSMSYAAPEILR 197
+ I HRD+K EN+LL + N+K++DFGFS F V + +T+CGS YAAPE+ +
Sbjct: 175 QKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNK-----LDTFCGSPPYAAPELFQ 229
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECK 257
GK Y D+WSLGV+L+ +++ S+PFD +++L E+ + KY R+ +S +C+
Sbjct: 230 GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY----RIPFYMSTDCE 285
Query: 258 TVVKHLLEPDPGLRHSATNVLDSEWI 283
++K LL +P R S ++ W+
Sbjct: 286 NLLKKLLVLNPIKRGSLEQIMKDRWM 311
Score = 150 bits (363), Expect = 2e-35
Identities = 78/237 (32%), Positives = 136/237 (57%), Gaps = 13/237 (5%)
Query: 353 LACKVID-TSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
+A K+ID T P K F RE+ ++ L+HP++V + + ++ M Y G+
Sbjct: 86 VAVKIIDKTQLNPTSLQKLF--REVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGE 143
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
+ ++++ G ++E +AR RQ+ A+QY H+ I HRD+K EN+LL + N+K++DFGF
Sbjct: 144 VFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGF 203
Query: 472 A-RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
+ V KL +TFCGS Y APE+ QG Y DVWSLG+++Y +++ ++PF+
Sbjct: 204 SNEFTVGNKL-----DTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFD 258
Query: 531 DKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+++K+L + + K+R + +S +C+ L+ +L N R + I+ W+
Sbjct: 259 GQNLKELRERVL--RGKYRIPFY--MSTDCENLLKKLLVLNPIKRGSLEQIMKDRWM 311
>AF154845-1|AAF72103.1| 795|Homo sapiens MARK protein.
Length = 795
Score = 171 bits (417), Expect = 5e-42
Identities = 89/266 (33%), Positives = 152/266 (57%), Gaps = 15/266 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L K +G+G +AKV L + +A KII+ + + K RE+ ++ L
Sbjct: 60 YRLQKTIGKGNFAKVKLARHVLTGRE----VAVKIIDKTQLNPTSLQKLF-REVRIMKIL 114
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP+++ + + + + Y+ M Y G++ Y++ +G + E +AR RQ+ +QY H
Sbjct: 115 NHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 174
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFS-RFCVESDNQPVLSETYCGSMSYAAPEILR 197
+ I HRD+K EN+LL + N+K++DFGFS F V + +T+CGS YAAPE+ +
Sbjct: 175 QKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNK-----LDTFCGSPPYAAPELFQ 229
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECK 257
GK Y D+WSLGV+L+ +++ S+PFD +++L E+ + KY R+ +S +C+
Sbjct: 230 GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY----RIPFYMSTDCE 285
Query: 258 TVVKHLLEPDPGLRHSATNVLDSEWI 283
++K LL +P R S ++ W+
Sbjct: 286 NLLKKLLVLNPIKRGSLEQIMKDRWM 311
Score = 150 bits (363), Expect = 2e-35
Identities = 78/237 (32%), Positives = 136/237 (57%), Gaps = 13/237 (5%)
Query: 353 LACKVID-TSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
+A K+ID T P K F RE+ ++ L+HP++V + + ++ M Y G+
Sbjct: 86 VAVKIIDKTQLNPTSLQKLF--REVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGE 143
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
+ ++++ G ++E +AR RQ+ A+QY H+ I HRD+K EN+LL + N+K++DFGF
Sbjct: 144 VFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGF 203
Query: 472 A-RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
+ V KL +TFCGS Y APE+ QG Y DVWSLG+++Y +++ ++PF+
Sbjct: 204 SNEFTVGNKL-----DTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFD 258
Query: 531 DKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+++K+L + + K+R + +S +C+ L+ +L N R + I+ W+
Sbjct: 259 GQNLKELRERVL--RGKYRIPFY--MSTDCENLLKKLLVLNPIKRGSLEQIMKDRWM 311
>M80359-1|AAA59991.1| 713|Homo sapiens protein p78 protein.
Length = 713
Score = 171 bits (415), Expect = 9e-42
Identities = 89/266 (33%), Positives = 150/266 (56%), Gaps = 15/266 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L K +G+G +AKV L + +A KII+ + + K RE+ ++ L
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGRE----VAIKIIDKTQLNPTSLQKLF-REVRIMKIL 110
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP+++ + + + + Y+ M Y G + Y++ +G + E +AR RQ+ +QY H
Sbjct: 111 NHPNIVKLFEVIETQKTLYLIMEYASGGKVFDYLVAHGRMKEKEARSKFRQIVSAVQYCH 170
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFS-RFCVESDNQPVLSETYCGSMSYAAPEILR 197
+ I HRD+K EN+LL A+ N+K++DFGFS F V +T+CGS YAAPE+ +
Sbjct: 171 QKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGK-----LDTFCGSPPYAAPELFQ 225
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECK 257
GK Y D+WSLGV+L+ +++ S+PFD +++L E+ + KY R+ +S +C+
Sbjct: 226 GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY----RIPFYMSTDCE 281
Query: 258 TVVKHLLEPDPGLRHSATNVLDSEWI 283
++K L +P R + ++ WI
Sbjct: 282 NLLKRFLVLNPIKRGTLEQIMKDRWI 307
Score = 151 bits (365), Expect = 1e-35
Identities = 80/237 (33%), Positives = 136/237 (57%), Gaps = 13/237 (5%)
Query: 353 LACKVID-TSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
+A K+ID T P K F RE+ ++ L+HP++V + + + ++ M Y G
Sbjct: 82 VAIKIIDKTQLNPTSLQKLF--REVRIMKILNHPNIVKLFEVIETQKTLYLIMEYASGGK 139
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
+ ++++ G ++E +AR RQ+ A+QY H+ I HRD+K EN+LL A+ N+K++DFGF
Sbjct: 140 VFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGF 199
Query: 472 A-RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
+ V KL +TFCGS Y APE+ QG Y DVWSLG+++Y +++ ++PF+
Sbjct: 200 SNEFTVGGKL-----DTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFD 254
Query: 531 DKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+++K+L + + K+R + +S +C+ L+ L N R + I+ WI
Sbjct: 255 GQNLKELRERVL--RGKYRIPFY--MSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307
>AY120867-1|AAM55491.1| 752|Homo sapiens MAP/microtubule
affinity-regulating kinase-like 1 protein.
Length = 752
Score = 171 bits (415), Expect = 9e-42
Identities = 87/266 (32%), Positives = 152/266 (57%), Gaps = 15/266 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L + +G+G +AKV L + +A KII+ + + K RE+ ++ L
Sbjct: 59 YRLLRTIGKGNFAKVKLARHILTGRE----VAIKIIDKTQLNPSSLQKLF-REVRIMKGL 113
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP+++ + + + + Y+ M Y G++ Y++ +G + E +AR RQ+ + Y H
Sbjct: 114 NHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCH 173
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFS-RFCVESDNQPVLSETYCGSMSYAAPEILR 197
+ I HRD+K EN+LL A N+K++DFGFS F + S +T+CGS YAAPE+ +
Sbjct: 174 QKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSK-----LDTFCGSPPYAAPELFQ 228
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECK 257
GK Y D+WSLGV+L+ +++ S+PFD +++L E+ + KY RV +S +C+
Sbjct: 229 GKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKY----RVPFYMSTDCE 284
Query: 258 TVVKHLLEPDPGLRHSATNVLDSEWI 283
++++ L +P R + ++ +WI
Sbjct: 285 SILRRFLVLNPAKRCTLEQIMKDKWI 310
Score = 149 bits (362), Expect = 2e-35
Identities = 76/237 (32%), Positives = 134/237 (56%), Gaps = 13/237 (5%)
Query: 353 LACKVID-TSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
+A K+ID T P K F RE+ ++ L+HP++V + + ++ M Y G+
Sbjct: 85 VAIKIIDKTQLNPSSLQKLF--REVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGE 142
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
+ ++++ G ++E +AR RQ+ A+ Y H+ I HRD+K EN+LL A N+K++DFGF
Sbjct: 143 VFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGF 202
Query: 472 A-RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
+ + KL +TFCGS Y APE+ QG Y D+WSLG+++Y +++ ++PF+
Sbjct: 203 SNEFTLGSKL-----DTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFD 257
Query: 531 DKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
++K+L + + K+R + +S +C+ ++ L N R + I+ +WI
Sbjct: 258 GHNLKELRERVL--RGKYRVPFY--MSTDCESILRRFLVLNPAKRCTLEQIMKDKWI 310
>AY057448-1|AAL23683.1| 752|Homo sapiens MARK4 serine/threonine
protein kinase protein.
Length = 752
Score = 171 bits (415), Expect = 9e-42
Identities = 87/266 (32%), Positives = 152/266 (57%), Gaps = 15/266 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L + +G+G +AKV L + +A KII+ + + K RE+ ++ L
Sbjct: 59 YRLLRTIGKGNFAKVKLARHILTGRE----VAIKIIDKTQLNPSSLQKLF-REVRIMKGL 113
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP+++ + + + + Y+ M Y G++ Y++ +G + E +AR RQ+ + Y H
Sbjct: 114 NHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCH 173
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFS-RFCVESDNQPVLSETYCGSMSYAAPEILR 197
+ I HRD+K EN+LL A N+K++DFGFS F + S +T+CGS YAAPE+ +
Sbjct: 174 QKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSK-----LDTFCGSPPYAAPELFQ 228
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECK 257
GK Y D+WSLGV+L+ +++ S+PFD +++L E+ + KY RV +S +C+
Sbjct: 229 GKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKY----RVPFYMSTDCE 284
Query: 258 TVVKHLLEPDPGLRHSATNVLDSEWI 283
++++ L +P R + ++ +WI
Sbjct: 285 SILRRFLVLNPAKRCTLEQIMKDKWI 310
Score = 149 bits (362), Expect = 2e-35
Identities = 76/237 (32%), Positives = 134/237 (56%), Gaps = 13/237 (5%)
Query: 353 LACKVID-TSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
+A K+ID T P K F RE+ ++ L+HP++V + + ++ M Y G+
Sbjct: 85 VAIKIIDKTQLNPSSLQKLF--REVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGE 142
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
+ ++++ G ++E +AR RQ+ A+ Y H+ I HRD+K EN+LL A N+K++DFGF
Sbjct: 143 VFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGF 202
Query: 472 A-RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
+ + KL +TFCGS Y APE+ QG Y D+WSLG+++Y +++ ++PF+
Sbjct: 203 SNEFTLGSKL-----DTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFD 257
Query: 531 DKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
++K+L + + K+R + +S +C+ ++ L N R + I+ +WI
Sbjct: 258 GHNLKELRERVL--RGKYRVPFY--MSTDCESILRRFLVLNPAKRCTLEQIMKDKWI 310
>AK075272-1|BAC11510.1| 752|Homo sapiens protein ( Homo sapiens
cDNA FLJ90791 fis, clone THYRO1001593, moderately
similar to PUTATIVE SERINE/THREONINE-PROTEIN KINASE P78
(EC 2.7.1.-). ).
Length = 752
Score = 171 bits (415), Expect = 9e-42
Identities = 87/266 (32%), Positives = 152/266 (57%), Gaps = 15/266 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L + +G+G +AKV L + +A KII+ + + K RE+ ++ L
Sbjct: 59 YRLLRTIGKGNFAKVKLARHILTGRE----VAIKIIDKTQLNPSSLQKLF-REVRIMKGL 113
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP+++ + + + + Y+ M Y G++ Y++ +G + E +AR RQ+ + Y H
Sbjct: 114 NHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCH 173
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFS-RFCVESDNQPVLSETYCGSMSYAAPEILR 197
+ I HRD+K EN+LL A N+K++DFGFS F + S +T+CGS YAAPE+ +
Sbjct: 174 QKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSK-----LDTFCGSPPYAAPELFQ 228
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECK 257
GK Y D+WSLGV+L+ +++ S+PFD +++L E+ + KY RV +S +C+
Sbjct: 229 GKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKY----RVPFYMSTDCE 284
Query: 258 TVVKHLLEPDPGLRHSATNVLDSEWI 283
++++ L +P R + ++ +WI
Sbjct: 285 SILRRFLVLNPAKRCTLEQIMKDKWI 310
Score = 149 bits (362), Expect = 2e-35
Identities = 76/237 (32%), Positives = 134/237 (56%), Gaps = 13/237 (5%)
Query: 353 LACKVID-TSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
+A K+ID T P K F RE+ ++ L+HP++V + + ++ M Y G+
Sbjct: 85 VAIKIIDKTQLNPSSLQKLF--REVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGE 142
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
+ ++++ G ++E +AR RQ+ A+ Y H+ I HRD+K EN+LL A N+K++DFGF
Sbjct: 143 VFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGF 202
Query: 472 A-RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
+ + KL +TFCGS Y APE+ QG Y D+WSLG+++Y +++ ++PF+
Sbjct: 203 SNEFTLGSKL-----DTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFD 257
Query: 531 DKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
++K+L + + K+R + +S +C+ ++ L N R + I+ +WI
Sbjct: 258 GHNLKELRERVL--RGKYRVPFY--MSTDCESILRRFLVLNPAKRCTLEQIMKDKWI 310
>AF465413-1|AAL69982.1| 753|Homo sapiens MAP/microtubule
affinity-regulating kinase 3 long isoform protein.
Length = 753
Score = 171 bits (415), Expect = 9e-42
Identities = 89/266 (33%), Positives = 150/266 (56%), Gaps = 15/266 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L K +G+G +AKV L + +A KII+ + + K RE+ ++ L
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGRE----VAIKIIDKTQLNPTSLQKLF-REVRIMKIL 110
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP+++ + + + + Y+ M Y G + Y++ +G + E +AR RQ+ +QY H
Sbjct: 111 NHPNIVKLFEVIETEKTLYLIMEYASGGKVFDYLVAHGRMKEKEARSKFRQIVSAVQYCH 170
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFS-RFCVESDNQPVLSETYCGSMSYAAPEILR 197
+ I HRD+K EN+LL A+ N+K++DFGFS F V +T+CGS YAAPE+ +
Sbjct: 171 QKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGK-----LDTFCGSPPYAAPELFQ 225
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECK 257
GK Y D+WSLGV+L+ +++ S+PFD +++L E+ + KY R+ +S +C+
Sbjct: 226 GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY----RIPFYMSTDCE 281
Query: 258 TVVKHLLEPDPGLRHSATNVLDSEWI 283
++K L +P R + ++ WI
Sbjct: 282 NLLKRFLVLNPIKRGTLEQIMKDRWI 307
Score = 150 bits (364), Expect = 1e-35
Identities = 80/237 (33%), Positives = 135/237 (56%), Gaps = 13/237 (5%)
Query: 353 LACKVID-TSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
+A K+ID T P K F RE+ ++ L+HP++V + + ++ M Y G
Sbjct: 82 VAIKIIDKTQLNPTSLQKLF--REVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGK 139
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
+ ++++ G ++E +AR RQ+ A+QY H+ I HRD+K EN+LL A+ N+K++DFGF
Sbjct: 140 VFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGF 199
Query: 472 A-RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
+ V KL +TFCGS Y APE+ QG Y DVWSLG+++Y +++ ++PF+
Sbjct: 200 SNEFTVGGKL-----DTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFD 254
Query: 531 DKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+++K+L + + K+R + +S +C+ L+ L N R + I+ WI
Sbjct: 255 GQNLKELRERVL--RGKYRIPFY--MSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307
>AB058763-1|BAB47489.1| 689|Homo sapiens KIAA1860 protein protein.
Length = 689
Score = 171 bits (415), Expect = 9e-42
Identities = 87/266 (32%), Positives = 152/266 (57%), Gaps = 15/266 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L + +G+G +AKV L + +A KII+ + + K RE+ ++ L
Sbjct: 60 YRLLRTIGKGNFAKVKLARHILTGRE----VAIKIIDKTQLNPSSLQKLF-REVRIMKGL 114
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP+++ + + + + Y+ M Y G++ Y++ +G + E +AR RQ+ + Y H
Sbjct: 115 NHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCH 174
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFS-RFCVESDNQPVLSETYCGSMSYAAPEILR 197
+ I HRD+K EN+LL A N+K++DFGFS F + S +T+CGS YAAPE+ +
Sbjct: 175 QKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSK-----LDTFCGSPPYAAPELFQ 229
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECK 257
GK Y D+WSLGV+L+ +++ S+PFD +++L E+ + KY RV +S +C+
Sbjct: 230 GKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKY----RVPFYMSTDCE 285
Query: 258 TVVKHLLEPDPGLRHSATNVLDSEWI 283
++++ L +P R + ++ +WI
Sbjct: 286 SILRRFLVLNPAKRCTLEQIMKDKWI 311
Score = 149 bits (362), Expect = 2e-35
Identities = 76/237 (32%), Positives = 134/237 (56%), Gaps = 13/237 (5%)
Query: 353 LACKVID-TSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
+A K+ID T P K F RE+ ++ L+HP++V + + ++ M Y G+
Sbjct: 86 VAIKIIDKTQLNPSSLQKLF--REVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGE 143
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
+ ++++ G ++E +AR RQ+ A+ Y H+ I HRD+K EN+LL A N+K++DFGF
Sbjct: 144 VFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGF 203
Query: 472 A-RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
+ + KL +TFCGS Y APE+ QG Y D+WSLG+++Y +++ ++PF+
Sbjct: 204 SNEFTLGSKL-----DTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFD 258
Query: 531 DKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
++K+L + + K+R + +S +C+ ++ L N R + I+ +WI
Sbjct: 259 GHNLKELRERVL--RGKYRVPFY--MSTDCESILRRFLVLNPAKRCTLEQIMKDKWI 311
>BC017306-1|AAH17306.1| 628|Homo sapiens NUAK family, SNF1-like
kinase, 2 protein.
Length = 628
Score = 169 bits (411), Expect = 3e-41
Identities = 92/265 (34%), Positives = 146/265 (55%), Gaps = 14/265 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+ + +G+G Y KV ++E S + +A K I K + + + REI+++ L
Sbjct: 53 YEFLETLGKGTYGKVK----KARESSGR-LVAIKSIRKDKIKDEQDLMHIRREIEIMSSL 107
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHPH+I +H +F+ +K I M Y GDL YI + +SE +AR + RQ+ + Y H
Sbjct: 108 NHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCH 167
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
+ + HRD+K EN+LL AN N+K++DFG S +Q +T+CGS YA+PEI+ G
Sbjct: 168 QNRVVHRDLKLENILLDANGNIKIADFGLSNLY----HQGKFLQTFCGSPLYASPEIVNG 223
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
KPY D WSLGV+L+++++ +MPFD + L +Q YR + + L
Sbjct: 224 KPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDACGL---- 279
Query: 259 VVKHLLEPDPGLRHSATNVLDSEWI 283
++ LL +P R + +V W+
Sbjct: 280 -IRWLLMVNPTRRATLEDVASHWWV 303
Score = 156 bits (378), Expect = 3e-37
Identities = 80/214 (37%), Positives = 124/214 (57%), Gaps = 9/214 (4%)
Query: 374 REIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQ 433
REIE++ L+HPH++ H +F+ K I M Y RGDL +++ +R + E +AR + RQ
Sbjct: 99 REIEIMSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQ 158
Query: 434 LALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLS 493
+ A+ Y H+ + HRD+K EN+LL AN N+K++DFG + + K +TFCGS
Sbjct: 159 IVSAVHYCHQNRVVHRDLKLENILLDANGNIKIADFGLSNLYHQGKF----LQTFCGSPL 214
Query: 494 YTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYI 553
Y +PEI+ G PY D WSLG+++Y++++ MPF D H ++ QI+ N +R
Sbjct: 215 YASPEIVNGKPYTGPEVDSWSLGVLLYILVHGTMPF-DGHDHKILVKQIS-NGAYREP-- 270
Query: 554 DTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
SD C LI +L N R + D+ + W+
Sbjct: 271 PKPSDAC-GLIRWLLMVNPTRRATLEDVASHWWV 303
>AK074830-1|BAC11234.1| 628|Homo sapiens protein ( Homo sapiens
cDNA FLJ90349 fis, clone NT2RP2003179, weakly similar to
PUTATIVE SERINE/THREONINE-PROTEIN KINASE EMK (EC
2.7.1.-). ).
Length = 628
Score = 169 bits (411), Expect = 3e-41
Identities = 92/265 (34%), Positives = 146/265 (55%), Gaps = 14/265 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+ + +G+G Y KV ++E S + +A K I K + + + REI+++ L
Sbjct: 53 YEFLETLGKGTYGKVK----KARESSGR-LVAIKSIRKDKIKDEQDLMHIRREIEIMSSL 107
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHPH+I +H +F+ +K I M Y GDL YI + +SE +AR + RQ+ + Y H
Sbjct: 108 NHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCH 167
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
+ + HRD+K EN+LL AN N+K++DFG S +Q +T+CGS YA+PEI+ G
Sbjct: 168 QNRVVHRDLKLENILLDANGNIKIADFGLSNLY----HQGKFLQTFCGSPLYASPEIVNG 223
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
KPY D WSLGV+L+++++ +MPFD + L +Q YR + + L
Sbjct: 224 KPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDACGL---- 279
Query: 259 VVKHLLEPDPGLRHSATNVLDSEWI 283
++ LL +P R + +V W+
Sbjct: 280 -IRWLLMVNPTRRATLEDVASHWWV 303
Score = 156 bits (378), Expect = 3e-37
Identities = 80/214 (37%), Positives = 124/214 (57%), Gaps = 9/214 (4%)
Query: 374 REIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQ 433
REIE++ L+HPH++ H +F+ K I M Y RGDL +++ +R + E +AR + RQ
Sbjct: 99 REIEIMSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQ 158
Query: 434 LALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLS 493
+ A+ Y H+ + HRD+K EN+LL AN N+K++DFG + + K +TFCGS
Sbjct: 159 IVSAVHYCHQNRVVHRDLKLENILLDANGNIKIADFGLSNLYHQGKF----LQTFCGSPL 214
Query: 494 YTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYI 553
Y +PEI+ G PY D WSLG+++Y++++ MPF D H ++ QI+ N +R
Sbjct: 215 YASPEIVNGKPYTGPEVDSWSLGVLLYILVHGTMPF-DGHDHKILVKQIS-NGAYREP-- 270
Query: 554 DTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
SD C LI +L N R + D+ + W+
Sbjct: 271 PKPSDAC-GLIRWLLMVNPTRRATLEDVASHWWV 303
>BC128510-1|AAI28511.1| 1203|Homo sapiens KIAA0999 protein protein.
Length = 1203
Score = 169 bits (410), Expect = 4e-41
Identities = 87/290 (30%), Positives = 161/290 (55%), Gaps = 14/290 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y++ + +G+G +A V + K+ +A KII+ + ++ + K RE+ ++ L
Sbjct: 8 YEIDRTIGKGNFAVVKRATHLVT----KAKVAIKIIDKTQLDEENLKKIF-REVQIMKML 62
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
HPH+I ++ + + + Y+ Y G++ +++ +G ++E +AR +Q+ + + H
Sbjct: 63 CHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCH 122
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
I HRD+K EN+LL AN N+K++DFGFS L +T+CGS YAAPE+ G
Sbjct: 123 CRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQ----LLKTWCGSPPYAAPELFEG 178
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
K Y D+WSLGVVL+V++ ++PFD + ++ L + + K+ R+ +S EC+
Sbjct: 179 KEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKF----RIPFFMSTECEH 234
Query: 259 VVKHLLEPDPGLRHSATNVLDSEWIAMDSRLTTLNAVEAAALKRAKEDRR 308
+++H+L DP R S + +W+ + + + A ++ KE+R+
Sbjct: 235 LIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRL-IAECQQLKEERQ 283
Score = 146 bits (353), Expect = 3e-34
Identities = 75/237 (31%), Positives = 135/237 (56%), Gaps = 9/237 (3%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A K+ID + + +KK RE++++ L HPH++ + + + ++ Y G++
Sbjct: 34 VAIKIIDKTQLDEENLKKIF-REVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI 92
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
+ ++ G + E +AR +Q+ A+ + H I HRD+K EN+LL AN N+K++DFGF+
Sbjct: 93 FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 152
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
+ +L +T+CGS Y APE+ +G Y D+WSLG+V+YV++ A+PF+
Sbjct: 153 NLFTPGQL----LKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGS 208
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAM 589
++ L +A++ + KFR + +S C+ LI ML + RL + I +W+ +
Sbjct: 209 TLQNL-RARV-LSGKFRIPFF--MSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKL 261
>AB088047-1|BAC03375.1| 752|Homo sapiens microtubule
affinity-regulating kinase-like1 protein.
Length = 752
Score = 169 bits (410), Expect = 4e-41
Identities = 87/266 (32%), Positives = 151/266 (56%), Gaps = 15/266 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L + +G+G AKV L + +A KII+ + + K RE+ ++ L
Sbjct: 59 YRLLRTIGKGNSAKVKLARHILTGRE----VAIKIIDKTQLNPSSLQKLF-REVRIMKGL 113
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP+++ + + + + Y+ M Y G++ Y++ +G + E +AR RQ+ + Y H
Sbjct: 114 NHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCH 173
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFS-RFCVESDNQPVLSETYCGSMSYAAPEILR 197
+ I HRD+K EN+LL A N+K++DFGFS F + S +T+CGS YAAPE+ +
Sbjct: 174 QKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSK-----LDTFCGSPPYAAPELFQ 228
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECK 257
GK Y D+WSLGV+L+ +++ S+PFD +++L E+ + KY RV +S +C+
Sbjct: 229 GKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKY----RVPFYMSTDCE 284
Query: 258 TVVKHLLEPDPGLRHSATNVLDSEWI 283
++++ L +P R + ++ +WI
Sbjct: 285 SILRRFLVLNPAKRCTLEQIMKDKWI 310
Score = 149 bits (362), Expect = 2e-35
Identities = 76/237 (32%), Positives = 134/237 (56%), Gaps = 13/237 (5%)
Query: 353 LACKVID-TSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
+A K+ID T P K F RE+ ++ L+HP++V + + ++ M Y G+
Sbjct: 85 VAIKIIDKTQLNPSSLQKLF--REVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGE 142
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
+ ++++ G ++E +AR RQ+ A+ Y H+ I HRD+K EN+LL A N+K++DFGF
Sbjct: 143 VFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGF 202
Query: 472 A-RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
+ + KL +TFCGS Y APE+ QG Y D+WSLG+++Y +++ ++PF+
Sbjct: 203 SNEFTLGSKL-----DTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFD 257
Query: 531 DKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
++K+L + + K+R + +S +C+ ++ L N R + I+ +WI
Sbjct: 258 GHNLKELRERVL--RGKYRVPFY--MSTDCESILRRFLVLNPAKRCTLEQIMKDKWI 310
>AB049127-1|BAB39380.1| 688|Homo sapiens MAP/microtubule
affinity-regulating kinase like 1 protein.
Length = 688
Score = 169 bits (410), Expect = 4e-41
Identities = 87/266 (32%), Positives = 151/266 (56%), Gaps = 15/266 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L + +G+G AKV L + +A KII+ + + K RE+ ++ L
Sbjct: 59 YRLLRTIGKGNSAKVKLARHILTGRE----VAIKIIDKTQLNPSSLQKLF-REVRIMKGL 113
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP+++ + + + + Y+ M Y G++ Y++ +G + E +AR RQ+ + Y H
Sbjct: 114 NHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCH 173
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFS-RFCVESDNQPVLSETYCGSMSYAAPEILR 197
+ I HRD+K EN+LL A N+K++DFGFS F + S +T+CGS YAAPE+ +
Sbjct: 174 QKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSK-----LDTFCGSPPYAAPELFQ 228
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECK 257
GK Y D+WSLGV+L+ +++ S+PFD +++L E+ + KY RV +S +C+
Sbjct: 229 GKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKY----RVPFYMSTDCE 284
Query: 258 TVVKHLLEPDPGLRHSATNVLDSEWI 283
++++ L +P R + ++ +WI
Sbjct: 285 SILRRFLVLNPAKRCTLEQIMKDKWI 310
Score = 149 bits (362), Expect = 2e-35
Identities = 76/237 (32%), Positives = 134/237 (56%), Gaps = 13/237 (5%)
Query: 353 LACKVID-TSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
+A K+ID T P K F RE+ ++ L+HP++V + + ++ M Y G+
Sbjct: 85 VAIKIIDKTQLNPSSLQKLF--REVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGE 142
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
+ ++++ G ++E +AR RQ+ A+ Y H+ I HRD+K EN+LL A N+K++DFGF
Sbjct: 143 VFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGF 202
Query: 472 A-RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
+ + KL +TFCGS Y APE+ QG Y D+WSLG+++Y +++ ++PF+
Sbjct: 203 SNEFTLGSKL-----DTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFD 257
Query: 531 DKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
++K+L + + K+R + +S +C+ ++ L N R + I+ +WI
Sbjct: 258 GHNLKELRERVL--RGKYRVPFY--MSTDCESILRRFLVLNPAKRCTLEQIMKDKWI 310
>AB023216-1|BAA76843.2| 1371|Homo sapiens KIAA0999 protein protein.
Length = 1371
Score = 169 bits (410), Expect = 4e-41
Identities = 87/290 (30%), Positives = 161/290 (55%), Gaps = 14/290 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y++ + +G+G +A V + K+ +A KII+ + ++ + K RE+ ++ L
Sbjct: 116 YEIDRTIGKGNFAVVKRATHLVT----KAKVAIKIIDKTQLDEENLKKIF-REVQIMKML 170
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
HPH+I ++ + + + Y+ Y G++ +++ +G ++E +AR +Q+ + + H
Sbjct: 171 CHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCH 230
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
I HRD+K EN+LL AN N+K++DFGFS L +T+CGS YAAPE+ G
Sbjct: 231 CRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQ----LLKTWCGSPPYAAPELFEG 286
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
K Y D+WSLGVVL+V++ ++PFD + ++ L + + K+ R+ +S EC+
Sbjct: 287 KEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKF----RIPFFMSTECEH 342
Query: 259 VVKHLLEPDPGLRHSATNVLDSEWIAMDSRLTTLNAVEAAALKRAKEDRR 308
+++H+L DP R S + +W+ + + + A ++ KE+R+
Sbjct: 343 LIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRL-IAECQQLKEERQ 391
Score = 146 bits (353), Expect = 3e-34
Identities = 75/237 (31%), Positives = 135/237 (56%), Gaps = 9/237 (3%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A K+ID + + +KK RE++++ L HPH++ + + + ++ Y G++
Sbjct: 142 VAIKIIDKTQLDEENLKKIF-REVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI 200
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
+ ++ G + E +AR +Q+ A+ + H I HRD+K EN+LL AN N+K++DFGF+
Sbjct: 201 FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 260
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
+ +L +T+CGS Y APE+ +G Y D+WSLG+V+YV++ A+PF+
Sbjct: 261 NLFTPGQL----LKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGS 316
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAM 589
++ L +A++ + KFR + +S C+ LI ML + RL + I +W+ +
Sbjct: 317 TLQNL-RARV-LSGKFRIPFF--MSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKL 369
>AP001751-1|BAA95536.1| 786|Homo sapiens SNF1LK protein.
Length = 786
Score = 167 bits (407), Expect = 8e-41
Identities = 88/268 (32%), Positives = 150/268 (55%), Gaps = 16/268 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y + + +G+G +A V L + K+ +A KII+ + + K RE+ ++ L
Sbjct: 27 YDIERTLGKGNFAVVKLARHRVT----KTQVAIKIIDKTRLDSSNLEKIY-REVQLMKLL 81
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHPH+I ++ + + K YI + +NG++ Y+ NG +SEN+AR Q+ ++Y H
Sbjct: 82 NHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCH 141
Query: 139 ELEIAHRDIKCENVLLTANFNVKLS---DFGFSRFCVESDNQPVLSETYCGSMSYAAPEI 195
+ I HRD+K EN+LL N ++KL+ DFGF F +P+ T+CGS YAAPE+
Sbjct: 142 DHHIVHRDLKTENLLLDGNMDIKLAGTEDFGFGNF--YKSGEPL--STWCGSPPYAAPEV 197
Query: 196 LRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLE 255
GK Y D+WSLGVVL+V++ S+PFD + L ++ + ++ R+ +S +
Sbjct: 198 FEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRF----RIPFFMSQD 253
Query: 256 CKTVVKHLLEPDPGLRHSATNVLDSEWI 283
C+++++ +L DP R + + W+
Sbjct: 254 CESLIRRMLVVDPARRITIAQIRQHRWM 281
Score = 136 bits (328), Expect = 3e-31
Identities = 74/238 (31%), Positives = 132/238 (55%), Gaps = 12/238 (5%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A K+ID + ++K RE++++ L+HPH++ + + + + +I + + G++
Sbjct: 53 VAIKIIDKTRLDSSNLEKIY-REVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEM 111
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLS---DF 469
+++ G + E++AR Q+ A++Y H+ I HRD+K EN+LL N ++KL+ DF
Sbjct: 112 FDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLAGTEDF 171
Query: 470 GFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPF 529
GF K E S T+CGS Y APE+ +G Y D+WSLG+V+YV++ ++PF
Sbjct: 172 GFGNF---YKSGEPLS-TWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPF 227
Query: 530 EDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+ ++ L Q + +FR + +S +C+ LI ML + R+ I I W+
Sbjct: 228 DGPNLPTLRQRVL--EGRFRIPFF--MSQDCESLIRRMLVVDPARRITIAQIRQHRWM 281
>EF056019-1|ABK30810.1| 552|Homo sapiens AMP-activated alpha 2
subunit protein.
Length = 552
Score = 163 bits (396), Expect = 2e-39
Identities = 91/268 (33%), Positives = 143/268 (53%), Gaps = 12/268 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y L +G G + KV + E+ HK +A KI+ K VV + REI L
Sbjct: 16 YVLGDTLGVGTFGKVNIGEHQLT--GHK--VAVKILNRQKIRSLDVVGKIKREIQNLKLF 71
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
HPH+I ++ + T +++ M Y G+L YI K+G V E +AR +Q+ + Y H
Sbjct: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
+ HRD+K ENVLL A+ N K++DFG S + SD + T CGS +YAAPE++ G
Sbjct: 132 RHMVVHRDLKPENVLLDAHMNAKIADFGLSN--MMSDGE--FLRTSCGSPNYAAPEVISG 187
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ Y D+WS GV+L+ +L ++PFDD + L+++ G + + L+ T
Sbjct: 188 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVF----YIPEYLNRSVAT 243
Query: 259 VVKHLLEPDPGLRHSATNVLDSEWIAMD 286
++ H+L+ DP R + ++ + EW D
Sbjct: 244 LLMHMLQVDPLKRATIKDIREHEWFKQD 271
Score = 140 bits (339), Expect = 1e-32
Identities = 74/225 (32%), Positives = 121/225 (53%), Gaps = 9/225 (4%)
Query: 366 DFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQED 425
D V K + REI+ L HPH++ + + +F+ M Y+ G+L +++ + G V+E
Sbjct: 56 DVVGK-IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEM 114
Query: 426 QARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRS 485
+AR +Q+ A+ Y H + HRD+K ENVLL A+ N K++DFG + M D +
Sbjct: 115 EARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF----L 170
Query: 486 ETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKN 545
T CGS +Y APE++ G Y D+WS G+++Y +L +PF+D+H+ L + +I
Sbjct: 171 RTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFK-KIRGG 229
Query: 546 WKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMD 590
+ Y++ + L+ ML+ + R I DI EW D
Sbjct: 230 VFYIPEYLNR---SVATLLMHMLQVDPLKRATIKDIREHEWFKQD 271
>BC069823-1|AAH69823.1| 552|Homo sapiens AMP-activated protein
kinase alpha 2 catalytic subunit protein.
Length = 552
Score = 163 bits (396), Expect = 2e-39
Identities = 91/268 (33%), Positives = 143/268 (53%), Gaps = 12/268 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y L +G G + KV + E+ HK +A KI+ K VV + REI L
Sbjct: 16 YVLGDTLGVGTFGKVKIGEHQLT--GHK--VAVKILNRQKIRSLDVVGKIKREIQNLKLF 71
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
HPH+I ++ + T +++ M Y G+L YI K+G V E +AR +Q+ + Y H
Sbjct: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
+ HRD+K ENVLL A+ N K++DFG S + SD + T CGS +YAAPE++ G
Sbjct: 132 RHMVVHRDLKPENVLLDAHMNAKIADFGLSN--MMSDGE--FLRTSCGSPNYAAPEVISG 187
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ Y D+WS GV+L+ +L ++PFDD + L+++ G + + L+ T
Sbjct: 188 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVF----YIPEYLNRSVAT 243
Query: 259 VVKHLLEPDPGLRHSATNVLDSEWIAMD 286
++ H+L+ DP R + ++ + EW D
Sbjct: 244 LLMHMLQVDPLKRATIKDIREHEWFKQD 271
Score = 140 bits (339), Expect = 1e-32
Identities = 74/225 (32%), Positives = 121/225 (53%), Gaps = 9/225 (4%)
Query: 366 DFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQED 425
D V K + REI+ L HPH++ + + +F+ M Y+ G+L +++ + G V+E
Sbjct: 56 DVVGK-IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEM 114
Query: 426 QARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRS 485
+AR +Q+ A+ Y H + HRD+K ENVLL A+ N K++DFG + M D +
Sbjct: 115 EARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF----L 170
Query: 486 ETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKN 545
T CGS +Y APE++ G Y D+WS G+++Y +L +PF+D+H+ L + +I
Sbjct: 171 RTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFK-KIRGG 229
Query: 546 WKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMD 590
+ Y++ + L+ ML+ + R I DI EW D
Sbjct: 230 VFYIPEYLNR---SVATLLMHMLQVDPLKRATIKDIREHEWFKQD 271
>BC069740-1|AAH69740.1| 552|Homo sapiens AMP-activated protein
kinase alpha 2 catalytic subunit protein.
Length = 552
Score = 163 bits (396), Expect = 2e-39
Identities = 91/268 (33%), Positives = 143/268 (53%), Gaps = 12/268 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y L +G G + KV + E+ HK +A KI+ K VV + REI L
Sbjct: 16 YVLGDTLGVGTFGKVKIGEHQLT--GHK--VAVKILNRQKIRSLDVVGKIKREIQNLKLF 71
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
HPH+I ++ + T +++ M Y G+L YI K+G V E +AR +Q+ + Y H
Sbjct: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
+ HRD+K ENVLL A+ N K++DFG S + SD + T CGS +YAAPE++ G
Sbjct: 132 RHMVVHRDLKPENVLLDAHMNAKIADFGLSN--MMSDGE--FLRTSCGSPNYAAPEVISG 187
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ Y D+WS GV+L+ +L ++PFDD + L+++ G + + L+ T
Sbjct: 188 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVF----YIPEYLNRSVAT 243
Query: 259 VVKHLLEPDPGLRHSATNVLDSEWIAMD 286
++ H+L+ DP R + ++ + EW D
Sbjct: 244 LLMHMLQVDPLKRATIKDIREHEWFKQD 271
Score = 140 bits (339), Expect = 1e-32
Identities = 74/225 (32%), Positives = 121/225 (53%), Gaps = 9/225 (4%)
Query: 366 DFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQED 425
D V K + REI+ L HPH++ + + +F+ M Y+ G+L +++ + G V+E
Sbjct: 56 DVVGK-IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEM 114
Query: 426 QARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRS 485
+AR +Q+ A+ Y H + HRD+K ENVLL A+ N K++DFG + M D +
Sbjct: 115 EARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF----L 170
Query: 486 ETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKN 545
T CGS +Y APE++ G Y D+WS G+++Y +L +PF+D+H+ L + +I
Sbjct: 171 RTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFK-KIRGG 229
Query: 546 WKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMD 590
+ Y++ + L+ ML+ + R I DI EW D
Sbjct: 230 VFYIPEYLNR---SVATLLMHMLQVDPLKRATIKDIREHEWFKQD 271
>BC069680-1|AAH69680.1| 552|Homo sapiens protein kinase,
AMP-activated, alpha 2 catalytic subunit protein.
Length = 552
Score = 163 bits (396), Expect = 2e-39
Identities = 91/268 (33%), Positives = 143/268 (53%), Gaps = 12/268 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y L +G G + KV + E+ HK +A KI+ K VV + REI L
Sbjct: 16 YVLGDTLGVGTFGKVKIGEHQLT--GHK--VAVKILNRQKIRSLDVVGKIKREIQNLKLF 71
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
HPH+I ++ + T +++ M Y G+L YI K+G V E +AR +Q+ + Y H
Sbjct: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
+ HRD+K ENVLL A+ N K++DFG S + SD + T CGS +YAAPE++ G
Sbjct: 132 RHMVVHRDLKPENVLLDAHMNAKIADFGLSN--MMSDGE--FLRTSCGSPNYAAPEVISG 187
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ Y D+WS GV+L+ +L ++PFDD + L+++ G + + L+ T
Sbjct: 188 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVF----YIPEYLNRSVAT 243
Query: 259 VVKHLLEPDPGLRHSATNVLDSEWIAMD 286
++ H+L+ DP R + ++ + EW D
Sbjct: 244 LLMHMLQVDPLKRATIKDIREHEWFKQD 271
Score = 140 bits (339), Expect = 1e-32
Identities = 74/225 (32%), Positives = 121/225 (53%), Gaps = 9/225 (4%)
Query: 366 DFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQED 425
D V K + REI+ L HPH++ + + +F+ M Y+ G+L +++ + G V+E
Sbjct: 56 DVVGK-IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEM 114
Query: 426 QARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRS 485
+AR +Q+ A+ Y H + HRD+K ENVLL A+ N K++DFG + M D +
Sbjct: 115 EARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF----L 170
Query: 486 ETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKN 545
T CGS +Y APE++ G Y D+WS G+++Y +L +PF+D+H+ L + +I
Sbjct: 171 RTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFK-KIRGG 229
Query: 546 WKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMD 590
+ Y++ + L+ ML+ + R I DI EW D
Sbjct: 230 VFYIPEYLNR---SVATLLMHMLQVDPLKRATIKDIREHEWFKQD 271
>AL035705-2|CAC17574.2| 552|Homo sapiens protein kinase,
AMP-activated, alpha 2 catalytic subunit protein.
Length = 552
Score = 163 bits (396), Expect = 2e-39
Identities = 91/268 (33%), Positives = 143/268 (53%), Gaps = 12/268 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y L +G G + KV + E+ HK +A KI+ K VV + REI L
Sbjct: 16 YVLGDTLGVGTFGKVKIGEHQLT--GHK--VAVKILNRQKIRSLDVVGKIKREIQNLKLF 71
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
HPH+I ++ + T +++ M Y G+L YI K+G V E +AR +Q+ + Y H
Sbjct: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
+ HRD+K ENVLL A+ N K++DFG S + SD + T CGS +YAAPE++ G
Sbjct: 132 RHMVVHRDLKPENVLLDAHMNAKIADFGLSN--MMSDGE--FLRTSCGSPNYAAPEVISG 187
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ Y D+WS GV+L+ +L ++PFDD + L+++ G + + L+ T
Sbjct: 188 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVF----YIPEYLNRSVAT 243
Query: 259 VVKHLLEPDPGLRHSATNVLDSEWIAMD 286
++ H+L+ DP R + ++ + EW D
Sbjct: 244 LLMHMLQVDPLKRATIKDIREHEWFKQD 271
Score = 140 bits (339), Expect = 1e-32
Identities = 74/225 (32%), Positives = 121/225 (53%), Gaps = 9/225 (4%)
Query: 366 DFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQED 425
D V K + REI+ L HPH++ + + +F+ M Y+ G+L +++ + G V+E
Sbjct: 56 DVVGK-IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEM 114
Query: 426 QARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRS 485
+AR +Q+ A+ Y H + HRD+K ENVLL A+ N K++DFG + M D +
Sbjct: 115 EARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF----L 170
Query: 486 ETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKN 545
T CGS +Y APE++ G Y D+WS G+++Y +L +PF+D+H+ L + +I
Sbjct: 171 RTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFK-KIRGG 229
Query: 546 WKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMD 590
+ Y++ + L+ ML+ + R I DI EW D
Sbjct: 230 VFYIPEYLNR---SVATLLMHMLQVDPLKRATIKDIREHEWFKQD 271
>U06454-1|AAA64745.1| 552|Homo sapiens AMP-activated protein kinase
protein.
Length = 552
Score = 159 bits (387), Expect = 2e-38
Identities = 89/264 (33%), Positives = 141/264 (53%), Gaps = 12/264 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y L +G G + KV + E+ HK +A KI+ K VV + REI L
Sbjct: 16 YVLGDTLGVGTFGKVKIGEHQLT--GHK--VAVKILNRQKIRSLDVVGKIKREIQNLKLF 71
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
HPH+I ++ + T +++ M Y G+L YI K+G V E +AR +Q+ + Y H
Sbjct: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
+ HRD+K ENVLL A+ N K++DFG S + SD + T CGS +Y APE++ G
Sbjct: 132 RHMVVHRDLKPENVLLDAHMNAKIADFGLSN--MMSDGE--FLRTSCGSPNYTAPEVISG 187
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ Y D+WS GV+L+ +L ++PFDD + L+++ G + + L+ T
Sbjct: 188 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVF----YIPEYLNRSVAT 243
Query: 259 VVKHLLEPDPGLRHSATNVLDSEW 282
++ H+L+ DP R + ++ + EW
Sbjct: 244 LLMHMLQVDPLKRATIKDIREHEW 267
Score = 140 bits (339), Expect = 1e-32
Identities = 74/221 (33%), Positives = 121/221 (54%), Gaps = 9/221 (4%)
Query: 366 DFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQED 425
D V K + REI+ L HPH++ + + +F+ M Y+ G+L +++ + G V+E
Sbjct: 56 DVVGK-IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEM 114
Query: 426 QARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRS 485
+AR +Q+ A+ Y H + HRD+K ENVLL A+ N K++DFG + M D +
Sbjct: 115 EARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF----L 170
Query: 486 ETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKN 545
T CGS +YTAPE++ G Y D+WS G+++Y +L +PF+D+H+ L + +I
Sbjct: 171 RTSCGSPNYTAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFK-KIRGG 229
Query: 546 WKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEW 586
+ Y++ + L+ ML+ + R I DI EW
Sbjct: 230 VFYIPEYLNR---SVATLLMHMLQVDPLKRATIKDIREHEW 267
>BC117183-1|AAI17184.1| 926|Homo sapiens SNF1-like kinase 2
protein.
Length = 926
Score = 159 bits (387), Expect = 2e-38
Identities = 83/269 (30%), Positives = 155/269 (57%), Gaps = 15/269 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFV-VKFLPREIDVLVR 77
Y + +G+G +A V L + K+ +A KII+ K+ D V ++ + RE+ ++
Sbjct: 20 YDIEGTLGKGNFAVVKLGRHRIT----KTEVAIKIID--KSQLDAVNLEKIYREVQIMKM 73
Query: 78 LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYL 137
L+HPH+I ++ + + K+ Y+ Y +NG++ Y+ +G ++E++AR Q+ + Y
Sbjct: 74 LDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYC 133
Query: 138 HELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILR 197
H +I HRD+K EN+LL N N+K++DFGF F + L T+CGS YAAPE+
Sbjct: 134 HGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGE----LLATWCGSPPYAAPEVFE 189
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECK 257
G+ Y D+WS+GVVL+V++ ++PFD + L ++ + ++ R+ +S +C+
Sbjct: 190 GQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRF----RIPYFMSEDCE 245
Query: 258 TVVKHLLEPDPGLRHSATNVLDSEWIAMD 286
+++ +L DP R + + + +W+ ++
Sbjct: 246 HLIRRMLVLDPSKRLTIAQIKEHKWMLIE 274
Score = 147 bits (357), Expect = 9e-35
Identities = 83/269 (30%), Positives = 145/269 (53%), Gaps = 14/269 (5%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A K+ID S ++K RE++++ L HPH++ + + + + ++ Y + G++
Sbjct: 46 VAIKIIDKSQLDAVNLEKIY-REVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEI 104
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
+++ G + E +AR Q+ A+ Y H +I HRD+K EN+LL N N+K++DFGF
Sbjct: 105 FDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFG 164
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
K E+ + T+CGS Y APE+ +G Y D+WS+G+V+YV++ A+PF+
Sbjct: 165 NFF---KSGELLA-TWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGP 220
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSR 592
+ L Q + +FR Y +S++C+ LI ML + RL I I +W+
Sbjct: 221 TLPILRQRVL--EGRFRIPYF--MSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWM----- 271
Query: 593 LLEWTPQETLAYKKAREEKNKLHKTVETV 621
L+E Q + Y + +E + + + E V
Sbjct: 272 LIEVPVQRPVLYPQEQENEPSIGEFNEQV 300
>BC113459-1|AAI13460.1| 926|Homo sapiens SNF1-like kinase 2
protein.
Length = 926
Score = 159 bits (387), Expect = 2e-38
Identities = 83/269 (30%), Positives = 155/269 (57%), Gaps = 15/269 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFV-VKFLPREIDVLVR 77
Y + +G+G +A V L + K+ +A KII+ K+ D V ++ + RE+ ++
Sbjct: 20 YDIEGTLGKGNFAVVKLGRHRIT----KTEVAIKIID--KSQLDAVNLEKIYREVQIMKM 73
Query: 78 LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYL 137
L+HPH+I ++ + + K+ Y+ Y +NG++ Y+ +G ++E++AR Q+ + Y
Sbjct: 74 LDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYC 133
Query: 138 HELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILR 197
H +I HRD+K EN+LL N N+K++DFGF F + L T+CGS YAAPE+
Sbjct: 134 HGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGE----LLATWCGSPPYAAPEVFE 189
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECK 257
G+ Y D+WS+GVVL+V++ ++PFD + L ++ + ++ R+ +S +C+
Sbjct: 190 GQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRF----RIPYFMSEDCE 245
Query: 258 TVVKHLLEPDPGLRHSATNVLDSEWIAMD 286
+++ +L DP R + + + +W+ ++
Sbjct: 246 HLIRRMLVLDPSKRLTIAQIKEHKWMLIE 274
Score = 147 bits (357), Expect = 9e-35
Identities = 83/269 (30%), Positives = 145/269 (53%), Gaps = 14/269 (5%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A K+ID S ++K RE++++ L HPH++ + + + + ++ Y + G++
Sbjct: 46 VAIKIIDKSQLDAVNLEKIY-REVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEI 104
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
+++ G + E +AR Q+ A+ Y H +I HRD+K EN+LL N N+K++DFGF
Sbjct: 105 FDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFG 164
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
K E+ + T+CGS Y APE+ +G Y D+WS+G+V+YV++ A+PF+
Sbjct: 165 NFF---KSGELLA-TWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGP 220
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSR 592
+ L Q + +FR Y +S++C+ LI ML + RL I I +W+
Sbjct: 221 TLPILRQRVL--EGRFRIPYF--MSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWM----- 271
Query: 593 LLEWTPQETLAYKKAREEKNKLHKTVETV 621
L+E Q + Y + +E + + + E V
Sbjct: 272 LIEVPVQRPVLYPQEQENEPSIGEFNEQV 300
>AB084424-1|BAB91442.1| 346|Homo sapiens KIAA0781 protein protein.
Length = 346
Score = 159 bits (387), Expect = 2e-38
Identities = 83/269 (30%), Positives = 155/269 (57%), Gaps = 15/269 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFV-VKFLPREIDVLVR 77
Y + +G+G +A V L + K+ +A KII+ K+ D V ++ + RE+ ++
Sbjct: 18 YDIEGTLGKGNFAVVKLGRHRIT----KTEVAIKIID--KSQLDAVNLEKIYREVQIMKM 71
Query: 78 LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYL 137
L+HPH+I ++ + + K+ Y+ Y +NG++ Y+ +G ++E++AR Q+ + Y
Sbjct: 72 LDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYC 131
Query: 138 HELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILR 197
H +I HRD+K EN+LL N N+K++DFGF F + L T+CGS YAAPE+
Sbjct: 132 HGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGE----LLATWCGSPPYAAPEVFE 187
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECK 257
G+ Y D+WS+GVVL+V++ ++PFD + L ++ + ++ R+ +S +C+
Sbjct: 188 GQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRF----RIPYFMSEDCE 243
Query: 258 TVVKHLLEPDPGLRHSATNVLDSEWIAMD 286
+++ +L DP R + + + +W+ ++
Sbjct: 244 HLIRRMLVLDPSKRLTIAQIKEHKWMLIE 272
Score = 147 bits (357), Expect = 9e-35
Identities = 83/269 (30%), Positives = 145/269 (53%), Gaps = 14/269 (5%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A K+ID S ++K RE++++ L HPH++ + + + + ++ Y + G++
Sbjct: 44 VAIKIIDKSQLDAVNLEKIY-REVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEI 102
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
+++ G + E +AR Q+ A+ Y H +I HRD+K EN+LL N N+K++DFGF
Sbjct: 103 FDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFG 162
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
K E+ + T+CGS Y APE+ +G Y D+WS+G+V+YV++ A+PF+
Sbjct: 163 NFF---KSGELLA-TWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGP 218
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSR 592
+ L Q + +FR Y +S++C+ LI ML + RL I I +W+
Sbjct: 219 TLPILRQRVL--EGRFRIPYF--MSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWM----- 269
Query: 593 LLEWTPQETLAYKKAREEKNKLHKTVETV 621
L+E Q + Y + +E + + + E V
Sbjct: 270 LIEVPVQRPVLYPQEQENEPSIGEFNEQV 298
>AB018324-1|BAA34501.3| 950|Homo sapiens KIAA0781 protein protein.
Length = 950
Score = 159 bits (387), Expect = 2e-38
Identities = 83/269 (30%), Positives = 155/269 (57%), Gaps = 15/269 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFV-VKFLPREIDVLVR 77
Y + +G+G +A V L + K+ +A KII+ K+ D V ++ + RE+ ++
Sbjct: 44 YDIEGTLGKGNFAVVKLGRHRIT----KTEVAIKIID--KSQLDAVNLEKIYREVQIMKM 97
Query: 78 LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYL 137
L+HPH+I ++ + + K+ Y+ Y +NG++ Y+ +G ++E++AR Q+ + Y
Sbjct: 98 LDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYC 157
Query: 138 HELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILR 197
H +I HRD+K EN+LL N N+K++DFGF F + L T+CGS YAAPE+
Sbjct: 158 HGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGE----LLATWCGSPPYAAPEVFE 213
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECK 257
G+ Y D+WS+GVVL+V++ ++PFD + L ++ + ++ R+ +S +C+
Sbjct: 214 GQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRF----RIPYFMSEDCE 269
Query: 258 TVVKHLLEPDPGLRHSATNVLDSEWIAMD 286
+++ +L DP R + + + +W+ ++
Sbjct: 270 HLIRRMLVLDPSKRLTIAQIKEHKWMLIE 298
Score = 147 bits (357), Expect = 9e-35
Identities = 83/269 (30%), Positives = 145/269 (53%), Gaps = 14/269 (5%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A K+ID S ++K RE++++ L HPH++ + + + + ++ Y + G++
Sbjct: 70 VAIKIIDKSQLDAVNLEKIY-REVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEI 128
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
+++ G + E +AR Q+ A+ Y H +I HRD+K EN+LL N N+K++DFGF
Sbjct: 129 FDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFG 188
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
K E+ + T+CGS Y APE+ +G Y D+WS+G+V+YV++ A+PF+
Sbjct: 189 NFF---KSGELLA-TWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGP 244
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSR 592
+ L Q + +FR Y +S++C+ LI ML + RL I I +W+
Sbjct: 245 TLPILRQRVL--EGRFRIPYF--MSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWM----- 295
Query: 593 LLEWTPQETLAYKKAREEKNKLHKTVETV 621
L+E Q + Y + +E + + + E V
Sbjct: 296 LIEVPVQRPVLYPQEQENEPSIGEFNEQV 324
>AB022017-1|BAA36547.1| 550|Homo sapiens AMP-activated protein
kinase alpha-1 protein.
Length = 550
Score = 159 bits (385), Expect = 4e-38
Identities = 93/269 (34%), Positives = 145/269 (53%), Gaps = 14/269 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y L +G G + KV + ++ HK +A KI+ K VV + REI L
Sbjct: 18 YILGDTLGVGTFGKVKVGKHELT--GHK--VAVKILNRQKIRSLDVVGKIRREIQNLKLF 73
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
HPH+I ++ + + ++ M Y G+L YI KNG + E ++R +Q+ G+ Y H
Sbjct: 74 RHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCH 133
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
+ HRD+K ENVLL A+ N K++DFG S + SD + T CGS +YAAPE++ G
Sbjct: 134 RHMVVHRDLKPENVLLDAHMNAKIADFGLSN--MMSDGE--FLRTSCGSPNYAAPEVISG 189
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQM-GKKYRFRSRVASILSLECK 257
+ Y D+WS GV+L+ +L ++PFDD + L+++ G Y + S++SL
Sbjct: 190 RLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISL--- 246
Query: 258 TVVKHLLEPDPGLRHSATNVLDSEWIAMD 286
+KH+L+ DP R S ++ + EW D
Sbjct: 247 --LKHMLQVDPMKRASIKDIREHEWFKQD 273
Score = 134 bits (325), Expect = 7e-31
Identities = 77/257 (29%), Positives = 129/257 (50%), Gaps = 11/257 (4%)
Query: 366 DFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQED 425
D V K + REI+ L HPH++ + + F+ M Y+ G+L +++ + G + E
Sbjct: 58 DVVGK-IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEK 116
Query: 426 QARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRS 485
++R +Q+ + Y H + HRD+K ENVLL A+ N K++DFG + M D +
Sbjct: 117 ESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF----L 172
Query: 486 ETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKN 545
T CGS +Y APE++ G Y D+WS G+++Y +L +PF+D H+ L + +I
Sbjct: 173 RTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFK-KICDG 231
Query: 546 WKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRLLEWTPQETLAYK 605
+ +Y ++ + L+ ML+ + R I DI EW D L ++ E +Y
Sbjct: 232 IFYTPQY---LNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQD--LPKYLFPEDPSYS 286
Query: 606 KAREEKNKLHKTVETVE 622
+ L + E E
Sbjct: 287 STMIDDEALKEVCEKFE 303
>BC037303-1|AAH37303.1| 550|Homo sapiens PRKAA1 protein protein.
Length = 550
Score = 157 bits (382), Expect = 9e-38
Identities = 92/269 (34%), Positives = 145/269 (53%), Gaps = 14/269 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y L +G G + KV + ++ HK +A KI+ K VV + REI L
Sbjct: 18 YILGDTLGVGTFGKVKVGKHELT--GHK--VAVKILNRQKIRSLDVVGKIRREIQNLKLF 73
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
HPH+I ++ + + ++ M Y G+L YI KNG + E ++R +Q+ G+ Y H
Sbjct: 74 RHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCH 133
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
+ HRD+K ENVLL A+ N K++DFG S + SD + T CGS +YAAPE++ G
Sbjct: 134 RHMVVHRDLKPENVLLDAHMNAKIADFGLSN--MMSDGE--FLRTSCGSPNYAAPEVISG 189
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQM-GKKYRFRSRVASILSLECK 257
+ Y D+WS GV+L+ +L ++PFDD + L+++ G Y + S++SL
Sbjct: 190 RLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISL--- 246
Query: 258 TVVKHLLEPDPGLRHSATNVLDSEWIAMD 286
+KH+L+ DP R + ++ + EW D
Sbjct: 247 --LKHMLQVDPMKRATIKDIREHEWFKQD 273
Score = 134 bits (324), Expect = 9e-31
Identities = 77/257 (29%), Positives = 129/257 (50%), Gaps = 11/257 (4%)
Query: 366 DFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQED 425
D V K + REI+ L HPH++ + + F+ M Y+ G+L +++ + G + E
Sbjct: 58 DVVGK-IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEK 116
Query: 426 QARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRS 485
++R +Q+ + Y H + HRD+K ENVLL A+ N K++DFG + M D +
Sbjct: 117 ESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF----L 172
Query: 486 ETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKN 545
T CGS +Y APE++ G Y D+WS G+++Y +L +PF+D H+ L + +I
Sbjct: 173 RTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFK-KICDG 231
Query: 546 WKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRLLEWTPQETLAYK 605
+ +Y ++ + L+ ML+ + R I DI EW D L ++ E +Y
Sbjct: 232 IFYTPQY---LNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQD--LPKYLFPEDPSYS 286
Query: 606 KAREEKNKLHKTVETVE 622
+ L + E E
Sbjct: 287 STMIDDEALKEVCEKFE 303
>AB011109-1|BAA25463.2| 698|Homo sapiens KIAA0537 protein protein.
Length = 698
Score = 157 bits (382), Expect = 9e-38
Identities = 84/265 (31%), Positives = 144/265 (54%), Gaps = 13/265 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L + +G+G Y KV + E +A K I K + + + REI+++ L
Sbjct: 92 YELQETLGKGTYGKVK----RATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSL 147
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHPH+I ++ +F+ K K I M Y G+L YI + +SE + R + RQ+ + Y H
Sbjct: 148 NHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCH 207
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
+ + HRD+K EN+LL N N+K++DFG S + D +T+CGS YA+PEI+ G
Sbjct: 208 KNGVVHRDLKLENILLDDNCNIKIADFGLSNL-YQKDK---FLQTFCGSPLYASPEIVNG 263
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+PY D W+LGV+L+ ++ +MPFD + L Q +YR ++ + + +
Sbjct: 264 RPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPS-----DARG 318
Query: 259 VVKHLLEPDPGLRHSATNVLDSEWI 283
+++ +L +P R + ++ + W+
Sbjct: 319 LIRWMLMVNPDRRATIEDIANHWWV 343
Score = 147 bits (356), Expect = 1e-34
Identities = 86/274 (31%), Positives = 144/274 (52%), Gaps = 14/274 (5%)
Query: 314 HKHPPKRQGDILEGPTRESAFRVYLAEYRNASKNDKLSILACKVIDTSTAPRDFVKKFLP 373
HKH K + ++ E + + +V A R + + ++A K I + +
Sbjct: 84 HKHNLKHRYELQETLGKGTYGKVKRATERFSGR-----VVAIKSIRKDKIKDEQDMVHIR 138
Query: 374 REIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQ 433
REIE++ L+HPH++ + +F+ + K I M Y +G+L +++ +R + E + R + RQ
Sbjct: 139 REIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQ 198
Query: 434 LALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLS 493
+ A+ Y H+ + HRD+K EN+LL N N+K++DFG + + K +TFCGS
Sbjct: 199 IVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDKF----LQTFCGSPL 254
Query: 494 YTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYI 553
Y +PEI+ G PY D W+LG+++Y ++ MPF+ K L + QI+ ++R
Sbjct: 255 YASPEIVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIR-QISSG-EYRE--- 309
Query: 554 DTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
T + + LI ML N R I DI N W+
Sbjct: 310 PTQPSDARGLIRWMLMVNPDRRATIEDIANHWWV 343
>AY505124-1|AAS86442.1| 778|Homo sapiens protein kinase SAD-B
protein.
Length = 778
Score = 156 bits (379), Expect = 2e-37
Identities = 82/264 (31%), Positives = 143/264 (54%), Gaps = 13/264 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L K +G+G V L + +A KI+ K + ++K + REI +L +
Sbjct: 34 YRLEKTLGKGQTGLVKLGVHCITGQK----VAIKIVNREKLSESVLMK-VEREIAILKLI 88
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
HPH++ +H +++ K Y+ + + G+L Y++K G ++ +AR + RQ+ L + H
Sbjct: 89 EHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCH 148
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
I HRD+K EN+LL N++++DFG + V L ET CGS YA PE+++G
Sbjct: 149 SYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDS----LLETSCGSPHYACPEVIKG 204
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ Y + D+WS GV+LF +L ++PFDD +R+L E K R + + +C++
Sbjct: 205 EKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLE----KVKRGVFHMPHFIPPDCQS 260
Query: 259 VVKHLLEPDPGLRHSATNVLDSEW 282
+++ ++E +P R S + W
Sbjct: 261 LLRGMIEVEPEKRLSLEQIQKHPW 284
Score = 138 bits (335), Expect = 4e-32
Identities = 68/234 (29%), Positives = 130/234 (55%), Gaps = 9/234 (3%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A K+++ + K + REI +L + HPH++ H +++ + ++ + ++ G+L
Sbjct: 60 VAIKIVNREKLSESVLMK-VEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGEL 118
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
++++++G + +AR + RQ+ A+ + H I HRD+K EN+LL N++++DFG A
Sbjct: 119 FDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMA 178
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
+ V L ET CGS Y PE+++G Y + D+WS G++++ +L A+PF+D
Sbjct: 179 SLQVGDSL----LETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDD 234
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEW 586
+++QL + K F + I +C+ L+ M+E + RL + I W
Sbjct: 235 NLRQLLEKV--KRGVFHMPHF--IPPDCQSLLRGMIEVEPEKRLSLEQIQKHPW 284
>AY458602-1|AAS10354.1| 778|Homo sapiens SAD1 kinase protein.
Length = 778
Score = 156 bits (379), Expect = 2e-37
Identities = 82/264 (31%), Positives = 143/264 (54%), Gaps = 13/264 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L K +G+G V L + +A KI+ K + ++K + REI +L +
Sbjct: 34 YRLEKTLGKGQTGLVKLGVHCITGQK----VAIKIVNREKLSESVLMK-VEREIAILKLI 88
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
HPH++ +H +++ K Y+ + + G+L Y++K G ++ +AR + RQ+ L + H
Sbjct: 89 EHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCH 148
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
I HRD+K EN+LL N++++DFG + V L ET CGS YA PE+++G
Sbjct: 149 SYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDS----LLETSCGSPHYACPEVIKG 204
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ Y + D+WS GV+LF +L ++PFDD +R+L E K R + + +C++
Sbjct: 205 EKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLE----KVKRGVFHMPHFIPPDCQS 260
Query: 259 VVKHLLEPDPGLRHSATNVLDSEW 282
+++ ++E +P R S + W
Sbjct: 261 LLRGMIEVEPEKRLSLEQIQKHPW 284
Score = 138 bits (335), Expect = 4e-32
Identities = 68/234 (29%), Positives = 130/234 (55%), Gaps = 9/234 (3%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A K+++ + K + REI +L + HPH++ H +++ + ++ + ++ G+L
Sbjct: 60 VAIKIVNREKLSESVLMK-VEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGEL 118
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
++++++G + +AR + RQ+ A+ + H I HRD+K EN+LL N++++DFG A
Sbjct: 119 FDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMA 178
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
+ V L ET CGS Y PE+++G Y + D+WS G++++ +L A+PF+D
Sbjct: 179 SLQVGDSL----LETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDD 234
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEW 586
+++QL + K F + I +C+ L+ M+E + RL + I W
Sbjct: 235 NLRQLLEKV--KRGVFHMPHF--IPPDCQSLLRGMIEVEPEKRLSLEQIQKHPW 284
>AF479827-1|AAL87698.1| 778|Homo sapiens protein kinase-like
protein protein.
Length = 778
Score = 156 bits (379), Expect = 2e-37
Identities = 82/264 (31%), Positives = 143/264 (54%), Gaps = 13/264 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L K +G+G V L + +A KI+ K + ++K + REI +L +
Sbjct: 34 YRLEKTLGKGQTGLVKLGVHCITGQK----VAIKIVNREKLSESVLMK-VEREIAILKLI 88
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
HPH++ +H +++ K Y+ + + G+L Y++K G ++ +AR + RQ+ L + H
Sbjct: 89 EHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCH 148
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
I HRD+K EN+LL N++++DFG + V L ET CGS YA PE+++G
Sbjct: 149 SYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDS----LLETSCGSPHYACPEVIKG 204
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ Y + D+WS GV+LF +L ++PFDD +R+L E K R + + +C++
Sbjct: 205 EKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLE----KVKRGVFHMPHFIPPDCQS 260
Query: 259 VVKHLLEPDPGLRHSATNVLDSEW 282
+++ ++E +P R S + W
Sbjct: 261 LLRGMIEVEPEKRLSLEQIQKHPW 284
Score = 138 bits (335), Expect = 4e-32
Identities = 68/234 (29%), Positives = 130/234 (55%), Gaps = 9/234 (3%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A K+++ + K + REI +L + HPH++ H +++ + ++ + ++ G+L
Sbjct: 60 VAIKIVNREKLSESVLMK-VEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGEL 118
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
++++++G + +AR + RQ+ A+ + H I HRD+K EN+LL N++++DFG A
Sbjct: 119 FDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMA 178
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
+ V L ET CGS Y PE+++G Y + D+WS G++++ +L A+PF+D
Sbjct: 179 SLQVGDSL----LETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDD 234
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEW 586
+++QL + K F + I +C+ L+ M+E + RL + I W
Sbjct: 235 NLRQLLEKV--KRGVFHMPHF--IPPDCQSLLRGMIEVEPEKRLSLEQIQKHPW 284
>AF479826-1|AAL87697.1| 794|Homo sapiens putative serine/threonine
protein kinase protein.
Length = 794
Score = 156 bits (379), Expect = 2e-37
Identities = 82/264 (31%), Positives = 143/264 (54%), Gaps = 13/264 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L K +G+G V L + +A KI+ K + ++K + REI +L +
Sbjct: 50 YRLEKTLGKGQTGLVKLGVHCITGQK----VAIKIVNREKLSESVLMK-VEREIAILKLI 104
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
HPH++ +H +++ K Y+ + + G+L Y++K G ++ +AR + RQ+ L + H
Sbjct: 105 EHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCH 164
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
I HRD+K EN+LL N++++DFG + V L ET CGS YA PE+++G
Sbjct: 165 SYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDS----LLETSCGSPHYACPEVIKG 220
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ Y + D+WS GV+LF +L ++PFDD +R+L E K R + + +C++
Sbjct: 221 EKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLE----KVKRGVFHMPHFIPPDCQS 276
Query: 259 VVKHLLEPDPGLRHSATNVLDSEW 282
+++ ++E +P R S + W
Sbjct: 277 LLRGMIEVEPEKRLSLEQIQKHPW 300
Score = 138 bits (335), Expect = 4e-32
Identities = 68/234 (29%), Positives = 130/234 (55%), Gaps = 9/234 (3%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A K+++ + K + REI +L + HPH++ H +++ + ++ + ++ G+L
Sbjct: 76 VAIKIVNREKLSESVLMK-VEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGEL 134
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
++++++G + +AR + RQ+ A+ + H I HRD+K EN+LL N++++DFG A
Sbjct: 135 FDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMA 194
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
+ V L ET CGS Y PE+++G Y + D+WS G++++ +L A+PF+D
Sbjct: 195 SLQVGDSL----LETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDD 250
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEW 586
+++QL + K F + I +C+ L+ M+E + RL + I W
Sbjct: 251 NLRQLLEKV--KRGVFHMPHF--IPPDCQSLLRGMIEVEPEKRLSLEQIQKHPW 300
>D79997-1|BAA11492.2| 656|Homo sapiens KIAA0175 protein.
Length = 656
Score = 154 bits (373), Expect = 1e-36
Identities = 92/283 (32%), Positives = 150/283 (53%), Gaps = 15/283 (5%)
Query: 5 KTTPSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFV 64
K T + + LL K Y+L + +G G +AKV L + + +A KI++ D
Sbjct: 3 KRTMKDYDELL-KYYELHETIGTGGFAKVKLACHILTGEM----VAIKIMDKNTLGSD-- 55
Query: 65 VKFLPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQAR 124
+ + EI+ L L H H+ ++ + + K ++ + Y G+L YI+ +SE + R
Sbjct: 56 LPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETR 115
Query: 125 VWTRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVE-SDNQPVLSET 183
V RQ+ + Y+H AHRD+K EN+L +KL DFG C + N+ +T
Sbjct: 116 VVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFG---LCAKPKGNKDYHLQT 172
Query: 184 YCGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYR 243
CGS++YAAPE+++GK Y D+WS+G++L+V++ +PFDD + LY++ M KY
Sbjct: 173 CCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKY- 231
Query: 244 FRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMD 286
V LS +++ +L+ DP R S N+L+ WI D
Sbjct: 232 ---DVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQD 271
Score = 145 bits (351), Expect = 5e-34
Identities = 77/247 (31%), Positives = 137/247 (55%), Gaps = 11/247 (4%)
Query: 352 ILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
++A K++D +T D + + EIE L L H H+ + + + K F+ + Y G+
Sbjct: 41 MVAIKIMDKNTLGSDLPR--IKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGE 98
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
L ++++ + + E++ R+ RQ+ A+ Y+H AHRD+K EN+L +KL DFG
Sbjct: 99 LFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFG- 157
Query: 472 ARMCVDKKLN-EIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
+C K N + +T CGSL+Y APE++QG YL DVWS+GI++YV++ +PF+
Sbjct: 158 --LCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFD 215
Query: 531 DKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMD 590
D ++ L++ K + + +S + L+ ML+ + + R+ + +++N WI D
Sbjct: 216 DDNVMALYK----KIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQD 271
Query: 591 SRL-LEW 596
+EW
Sbjct: 272 YNYPVEW 278
>BC014039-1|AAH14039.1| 651|Homo sapiens maternal embryonic leucine
zipper kinase protein.
Length = 651
Score = 153 bits (372), Expect = 1e-36
Identities = 89/273 (32%), Positives = 145/273 (53%), Gaps = 14/273 (5%)
Query: 15 LTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDV 74
L K Y+L + +G G +AKV L + + +A KI++ D + + EI+
Sbjct: 7 LLKYYELHETIGTGGFAKVKLACHILTGEM----VAIKIMDKNTLGSD--LPRIKTEIEA 60
Query: 75 LVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGL 134
L L H H+ ++ + + K ++ + Y G+L YI+ +SE + RV RQ+ +
Sbjct: 61 LKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAV 120
Query: 135 QYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVE-SDNQPVLSETYCGSMSYAAP 193
Y+H AHRD+K EN+L +KL DFG C + N+ +T CGS++YAAP
Sbjct: 121 AYVHSQGYAHRDLKPENLLFDEYHKLKLIDFG---LCAKPKGNKDYHLQTCCGSLAYAAP 177
Query: 194 EILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILS 253
E+++GK Y D+WS+G++L+V++ +PFDD + LY++ M KY V LS
Sbjct: 178 ELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKY----DVPKWLS 233
Query: 254 LECKTVVKHLLEPDPGLRHSATNVLDSEWIAMD 286
+++ +L+ DP R S N+L+ WI D
Sbjct: 234 PSSILLLQQMLQVDPKKRISMKNLLNHPWIMQD 266
Score = 145 bits (351), Expect = 5e-34
Identities = 77/247 (31%), Positives = 137/247 (55%), Gaps = 11/247 (4%)
Query: 352 ILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
++A K++D +T D + + EIE L L H H+ + + + K F+ + Y G+
Sbjct: 36 MVAIKIMDKNTLGSDLPR--IKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGE 93
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
L ++++ + + E++ R+ RQ+ A+ Y+H AHRD+K EN+L +KL DFG
Sbjct: 94 LFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFG- 152
Query: 472 ARMCVDKKLN-EIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
+C K N + +T CGSL+Y APE++QG YL DVWS+GI++YV++ +PF+
Sbjct: 153 --LCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFD 210
Query: 531 DKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMD 590
D ++ L++ K + + +S + L+ ML+ + + R+ + +++N WI D
Sbjct: 211 DDNVMALYK----KIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQD 266
Query: 591 SRL-LEW 596
+EW
Sbjct: 267 YNYPVEW 273
>AL442063-1|CAI16995.2| 651|Homo sapiens maternal embryonic leucine
zipper kinase protein.
Length = 651
Score = 153 bits (372), Expect = 1e-36
Identities = 89/273 (32%), Positives = 145/273 (53%), Gaps = 14/273 (5%)
Query: 15 LTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDV 74
L K Y+L + +G G +AKV L + + +A KI++ D + + EI+
Sbjct: 7 LLKYYELHETIGTGGFAKVKLACHILTGEM----VAIKIMDKNTLGSD--LPRIKTEIEA 60
Query: 75 LVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGL 134
L L H H+ ++ + + K ++ + Y G+L YI+ +SE + RV RQ+ +
Sbjct: 61 LKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAV 120
Query: 135 QYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVE-SDNQPVLSETYCGSMSYAAP 193
Y+H AHRD+K EN+L +KL DFG C + N+ +T CGS++YAAP
Sbjct: 121 AYVHSQGYAHRDLKPENLLFDEYHKLKLIDFG---LCAKPKGNKDYHLQTCCGSLAYAAP 177
Query: 194 EILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILS 253
E+++GK Y D+WS+G++L+V++ +PFDD + LY++ M KY V LS
Sbjct: 178 ELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKY----DVPKWLS 233
Query: 254 LECKTVVKHLLEPDPGLRHSATNVLDSEWIAMD 286
+++ +L+ DP R S N+L+ WI D
Sbjct: 234 PSSILLLQQMLQVDPKKRISMKNLLNHPWIMQD 266
Score = 145 bits (351), Expect = 5e-34
Identities = 77/247 (31%), Positives = 137/247 (55%), Gaps = 11/247 (4%)
Query: 352 ILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
++A K++D +T D + + EIE L L H H+ + + + K F+ + Y G+
Sbjct: 36 MVAIKIMDKNTLGSDLPR--IKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGE 93
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
L ++++ + + E++ R+ RQ+ A+ Y+H AHRD+K EN+L +KL DFG
Sbjct: 94 LFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFG- 152
Query: 472 ARMCVDKKLN-EIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
+C K N + +T CGSL+Y APE++QG YL DVWS+GI++YV++ +PF+
Sbjct: 153 --LCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFD 210
Query: 531 DKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMD 590
D ++ L++ K + + +S + L+ ML+ + + R+ + +++N WI D
Sbjct: 211 DDNVMALYK----KIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQD 266
Query: 591 SRL-LEW 596
+EW
Sbjct: 267 YNYPVEW 273
>AL354932-1|CAI11034.2| 651|Homo sapiens maternal embryonic leucine
zipper kinase protein.
Length = 651
Score = 153 bits (372), Expect = 1e-36
Identities = 89/273 (32%), Positives = 145/273 (53%), Gaps = 14/273 (5%)
Query: 15 LTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDV 74
L K Y+L + +G G +AKV L + + +A KI++ D + + EI+
Sbjct: 7 LLKYYELHETIGTGGFAKVKLACHILTGEM----VAIKIMDKNTLGSD--LPRIKTEIEA 60
Query: 75 LVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGL 134
L L H H+ ++ + + K ++ + Y G+L YI+ +SE + RV RQ+ +
Sbjct: 61 LKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAV 120
Query: 135 QYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVE-SDNQPVLSETYCGSMSYAAP 193
Y+H AHRD+K EN+L +KL DFG C + N+ +T CGS++YAAP
Sbjct: 121 AYVHSQGYAHRDLKPENLLFDEYHKLKLIDFG---LCAKPKGNKDYHLQTCCGSLAYAAP 177
Query: 194 EILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILS 253
E+++GK Y D+WS+G++L+V++ +PFDD + LY++ M KY V LS
Sbjct: 178 ELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKY----DVPKWLS 233
Query: 254 LECKTVVKHLLEPDPGLRHSATNVLDSEWIAMD 286
+++ +L+ DP R S N+L+ WI D
Sbjct: 234 PSSILLLQQMLQVDPKKRISMKNLLNHPWIMQD 266
Score = 145 bits (351), Expect = 5e-34
Identities = 77/247 (31%), Positives = 137/247 (55%), Gaps = 11/247 (4%)
Query: 352 ILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
++A K++D +T D + + EIE L L H H+ + + + K F+ + Y G+
Sbjct: 36 MVAIKIMDKNTLGSDLPR--IKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGE 93
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
L ++++ + + E++ R+ RQ+ A+ Y+H AHRD+K EN+L +KL DFG
Sbjct: 94 LFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFG- 152
Query: 472 ARMCVDKKLN-EIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
+C K N + +T CGSL+Y APE++QG YL DVWS+GI++YV++ +PF+
Sbjct: 153 --LCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFD 210
Query: 531 DKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMD 590
D ++ L++ K + + +S + L+ ML+ + + R+ + +++N WI D
Sbjct: 211 DDNVMALYK----KIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQD 266
Query: 591 SRL-LEW 596
+EW
Sbjct: 267 YNYPVEW 273
>AK222811-1|BAD96531.1| 651|Homo sapiens maternal embryonic leucine
zipper kinase variant protein.
Length = 651
Score = 153 bits (372), Expect = 1e-36
Identities = 89/273 (32%), Positives = 145/273 (53%), Gaps = 14/273 (5%)
Query: 15 LTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDV 74
L K Y+L + +G G +AKV L + + +A KI++ D + + EI+
Sbjct: 7 LLKYYELHETIGTGGFAKVKLACHILTGEM----VAIKIMDKNTLGSD--LPRIKTEIEA 60
Query: 75 LVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGL 134
L L H H+ ++ + + K ++ + Y G+L YI+ +SE + RV RQ+ +
Sbjct: 61 LKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAV 120
Query: 135 QYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVE-SDNQPVLSETYCGSMSYAAP 193
Y+H AHRD+K EN+L +KL DFG C + N+ +T CGS++YAAP
Sbjct: 121 AYVHSQGYAHRDLKPENLLFDEYHKLKLIDFG---LCAKPKGNKDYHLQTCCGSLAYAAP 177
Query: 194 EILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILS 253
E+++GK Y D+WS+G++L+V++ +PFDD + LY++ M KY V LS
Sbjct: 178 ELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKY----DVPKWLS 233
Query: 254 LECKTVVKHLLEPDPGLRHSATNVLDSEWIAMD 286
+++ +L+ DP R S N+L+ WI D
Sbjct: 234 PSSILLLQQMLQVDPKKRISMKNLLNHPWIMQD 266
Score = 145 bits (351), Expect = 5e-34
Identities = 77/247 (31%), Positives = 137/247 (55%), Gaps = 11/247 (4%)
Query: 352 ILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
++A K++D +T D + + EIE L L H H+ + + + K F+ + Y G+
Sbjct: 36 MVAIKIMDKNTLGSDLPR--IKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGE 93
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
L ++++ + + E++ R+ RQ+ A+ Y+H AHRD+K EN+L +KL DFG
Sbjct: 94 LFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFG- 152
Query: 472 ARMCVDKKLN-EIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
+C K N + +T CGSL+Y APE++QG YL DVWS+GI++YV++ +PF+
Sbjct: 153 --LCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFD 210
Query: 531 DKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMD 590
D ++ L++ K + + +S + L+ ML+ + + R+ + +++N WI D
Sbjct: 211 DDNVMALYK----KIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQD 266
Query: 591 SRL-LEW 596
+EW
Sbjct: 267 YNYPVEW 273
>AY505125-1|AAS86443.1| 696|Homo sapiens protein kinase SAD-A
protein.
Length = 696
Score = 153 bits (371), Expect = 2e-36
Identities = 82/264 (31%), Positives = 143/264 (54%), Gaps = 13/264 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L K +G+G V L + +A KI+ K + ++K + REI +L +
Sbjct: 19 YRLEKTLGKGQTGLVKLGVHCVTCQK----VAIKIVNREKLSESVLMK-VEREIAILKLI 73
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
HPH++ +H +++ K Y+ + + G+L Y++K G ++ +AR + RQ+ L + H
Sbjct: 74 EHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCH 133
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
I HRD+K EN+LL N++++DFG + V L ET CGS YA PE++RG
Sbjct: 134 SHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDS----LLETSCGSPHYACPEVIRG 189
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ Y + D+WS GV+LF +L ++PFDD +R+L E K R + + +C++
Sbjct: 190 EKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLE----KVKRGVFHMPHFIPPDCQS 245
Query: 259 VVKHLLEPDPGLRHSATNVLDSEW 282
+++ ++E D R + ++ W
Sbjct: 246 LLRGMIEVDAARRLTLEHIQKHIW 269
Score = 136 bits (330), Expect = 2e-31
Identities = 69/234 (29%), Positives = 130/234 (55%), Gaps = 9/234 (3%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A K+++ + K + REI +L + HPH++ H +++ + ++ + ++ G+L
Sbjct: 45 VAIKIVNREKLSESVLMK-VEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGEL 103
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
++++++G + +AR + RQ+ A+ + H I HRD+K EN+LL N++++DFG A
Sbjct: 104 FDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMA 163
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
+ V L ET CGS Y PE+++G Y + DVWS G++++ +L A+PF+D
Sbjct: 164 SLQVGDSL----LETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDD 219
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEW 586
+++QL + K F + I +C+ L+ M+E + RL + I W
Sbjct: 220 NLRQLLEKV--KRGVFHMPHF--IPPDCQSLLRGMIEVDAARRLTLEHIQKHIW 269
>BC111088-1|AAI11089.1| 252|Homo sapiens TSSK4 protein protein.
Length = 252
Score = 153 bits (370), Expect = 2e-36
Identities = 83/220 (37%), Positives = 124/220 (56%), Gaps = 20/220 (9%)
Query: 78 LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYL 137
L H +LI+ + + ++ YI + + GD+L +I + G SE A W QL LG+ YL
Sbjct: 4 LRHKYLINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYL 63
Query: 138 HELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPV--------------LSET 183
H I HRD+K EN+LL NVK+SDFGF++ + NQPV LS+T
Sbjct: 64 HSKSIVHRDLKLENLLLDKWENVKISDFGFAK--MVPSNQPVGCSPSYRQVNCFSHLSQT 121
Query: 184 YCGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYR 243
YCGS +YA PEILRG PY P +D WS+GV+L+ ++ +PFDDT ++KL + K+
Sbjct: 122 YCGSFAYACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQ-KEVT 180
Query: 244 FRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
F + +S ECK ++ +L R + +++ W+
Sbjct: 181 FPAN--HTISQECKNLILQMLR-QATKRATILDIIKDSWV 217
Score = 147 bits (356), Expect = 1e-34
Identities = 84/250 (33%), Positives = 135/250 (54%), Gaps = 22/250 (8%)
Query: 382 LSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYM 441
L H +L++ + + + +I + + GD+LE++ + GA E A W QL L I Y+
Sbjct: 4 LRHKYLINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYL 63
Query: 442 HELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKK-------LNEIR-----SETFC 489
H I HRD+K EN+LL +NVK+SDFGFA+M + ++ S+T+C
Sbjct: 64 HSKSIVHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYC 123
Query: 490 GSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFR 549
GS +Y PEIL+G PY P +D WS+G+++Y ++ +PF+D ++K+L + + K F
Sbjct: 124 GSFAYACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLR-ETQKEVTFP 182
Query: 550 SRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRLLEWTPQETLAYKKARE 609
+ + TIS CK LI ML R I DI+ W+ L++ P++ + E
Sbjct: 183 ANH--TISQECKNLILQMLR-QATKRATILDIIKDSWV------LKFQPEQPTHEIRLLE 233
Query: 610 EKNKLHKTVE 619
+LH T +
Sbjct: 234 AMCQLHNTTK 243
>AK131534-1|BAD18671.1| 766|Homo sapiens protein ( Homo sapiens
cDNA FLJ16763 fis, clone BRAMY3018357, weakly similar
to SNF1-related protein kinase KIN10 (EC 2.7.1.-). ).
Length = 766
Score = 152 bits (368), Expect = 4e-36
Identities = 75/234 (32%), Positives = 132/234 (56%), Gaps = 9/234 (3%)
Query: 49 LACKIIETAKAPKDFVVKFLPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDL 108
+A KI+ K + ++K + REI +L + HPH++ +H +++ K Y+ + + G+L
Sbjct: 91 VAIKIVNREKLSESVLMK-VEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGEL 149
Query: 109 LSYILKNGCVSENQARVWTRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFS 168
Y++K G ++ +AR + RQ+ L + H I HRD+K EN+LL N++++DFG +
Sbjct: 150 FDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMA 209
Query: 169 RFCVESDNQPVLSETYCGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDT 228
V L ET CGS YA PE++RG+ Y + D+WS GV+LF +L ++PFDD
Sbjct: 210 SLQVGDS----LLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDD 265
Query: 229 RMRKLYEQQMGKKYRFRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEW 282
+R+L E K R + + +C+++++ ++E D R + ++ W
Sbjct: 266 NLRQLLE----KVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIW 315
Score = 136 bits (330), Expect = 2e-31
Identities = 69/234 (29%), Positives = 130/234 (55%), Gaps = 9/234 (3%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A K+++ + K + REI +L + HPH++ H +++ + ++ + ++ G+L
Sbjct: 91 VAIKIVNREKLSESVLMK-VEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGEL 149
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
++++++G + +AR + RQ+ A+ + H I HRD+K EN+LL N++++DFG A
Sbjct: 150 FDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMA 209
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
+ V L ET CGS Y PE+++G Y + DVWS G++++ +L A+PF+D
Sbjct: 210 SLQVGDSL----LETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDD 265
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEW 586
+++QL + K F + I +C+ L+ M+E + RL + I W
Sbjct: 266 NLRQLLEKV--KRGVFHMPHF--IPPDCQSLLRGMIEVDAARRLTLEHIQKHIW 315
>AY166857-1|AAN87839.1| 668|Homo sapiens serine/threonine protein
kinase isoform protein.
Length = 668
Score = 151 bits (367), Expect = 6e-36
Identities = 82/264 (31%), Positives = 142/264 (53%), Gaps = 13/264 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L K +G+G V L + +A KI+ K + ++K + REI +L +
Sbjct: 19 YRLEKTLGKGQTGLVKLGVHCVTCQK----VAIKIVNREKLSESVLMK-VEREIAILKLI 73
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
HPH++ +H +++ K Y+ + + G+L Y++K G ++ +AR + RQ+ L + H
Sbjct: 74 EHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCH 133
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
I HRD+K EN+LL N++++DFG + V L ET CGS YA PE++RG
Sbjct: 134 SHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDS----LLETSCGSPHYACPEVIRG 189
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ Y + D+WS GV+LF +L ++PFDD +R+L E K R + + +C++
Sbjct: 190 EKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLE----KVKRGVFHMPHFIPPDCQS 245
Query: 259 VVKHLLEPDPGLRHSATNVLDSEW 282
+++ + E D R + ++ W
Sbjct: 246 LLRGMSEVDAARRLTLEHIQKHIW 269
Score = 135 bits (326), Expect = 5e-31
Identities = 69/234 (29%), Positives = 129/234 (55%), Gaps = 9/234 (3%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A K+++ + K + REI +L + HPH++ H +++ + ++ + ++ G+L
Sbjct: 45 VAIKIVNREKLSESVLMK-VEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGEL 103
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
++++++G + +AR + RQ+ A+ + H I HRD+K EN+LL N++++DFG A
Sbjct: 104 FDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMA 163
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
+ V L ET CGS Y PE+++G Y + DVWS G++++ +L A+PF+D
Sbjct: 164 SLQVGDSL----LETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDD 219
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEW 586
+++QL + K F + I +C+ L+ M E + RL + I W
Sbjct: 220 NLRQLLEKV--KRGVFHMPHF--IPPDCQSLLRGMSEVDAARRLTLEHIQKHIW 269
>AF533880-1|AAP97727.1| 674|Homo sapiens putative serine/threonine
protein kinase variant B3 protein.
Length = 674
Score = 151 bits (367), Expect = 6e-36
Identities = 82/264 (31%), Positives = 142/264 (53%), Gaps = 13/264 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L K +G+G V L + +A KI+ K + ++K + REI +L +
Sbjct: 19 YRLEKTLGKGQTGLVKLGVHCVTCQK----VAIKIVNREKLSESVLMK-VEREIAILKLI 73
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
HPH++ +H +++ K Y+ + + G+L Y++K G ++ +AR + RQ+ L + H
Sbjct: 74 EHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCH 133
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
I HRD+K EN+LL N++++DFG + V L ET CGS YA PE++RG
Sbjct: 134 SHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDS----LLETSCGSPHYACPEVIRG 189
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ Y + D+WS GV+LF +L ++PFDD +R+L E K R + + +C++
Sbjct: 190 EKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLE----KVKRGVFHMPHFIPPDCQS 245
Query: 259 VVKHLLEPDPGLRHSATNVLDSEW 282
+++ + E D R + ++ W
Sbjct: 246 LLRGMSEVDAARRLTLEHIQKHIW 269
Score = 135 bits (326), Expect = 5e-31
Identities = 69/234 (29%), Positives = 129/234 (55%), Gaps = 9/234 (3%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A K+++ + K + REI +L + HPH++ H +++ + ++ + ++ G+L
Sbjct: 45 VAIKIVNREKLSESVLMK-VEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGEL 103
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
++++++G + +AR + RQ+ A+ + H I HRD+K EN+LL N++++DFG A
Sbjct: 104 FDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMA 163
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
+ V L ET CGS Y PE+++G Y + DVWS G++++ +L A+PF+D
Sbjct: 164 SLQVGDSL----LETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDD 219
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEW 586
+++QL + K F + I +C+ L+ M E + RL + I W
Sbjct: 220 NLRQLLEKV--KRGVFHMPHF--IPPDCQSLLRGMSEVDAARRLTLEHIQKHIW 269
>AF533879-1|AAP97726.1| 736|Homo sapiens putative serine/threonine
protein kinase variant C protein.
Length = 736
Score = 151 bits (367), Expect = 6e-36
Identities = 82/264 (31%), Positives = 142/264 (53%), Gaps = 13/264 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L K +G+G V L + +A KI+ K + ++K + REI +L +
Sbjct: 19 YRLEKTLGKGQTGLVKLGVHCVTCQK----VAIKIVNREKLSESVLMK-VEREIAILKLI 73
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
HPH++ +H +++ K Y+ + + G+L Y++K G ++ +AR + RQ+ L + H
Sbjct: 74 EHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCH 133
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
I HRD+K EN+LL N++++DFG + V L ET CGS YA PE++RG
Sbjct: 134 SHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDS----LLETSCGSPHYACPEVIRG 189
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ Y + D+WS GV+LF +L ++PFDD +R+L E K R + + +C++
Sbjct: 190 EKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLE----KVKRGVFHMPHFIPPDCQS 245
Query: 259 VVKHLLEPDPGLRHSATNVLDSEW 282
+++ + E D R + ++ W
Sbjct: 246 LLRGMSEVDAARRLTLEHIQKHIW 269
Score = 135 bits (326), Expect = 5e-31
Identities = 69/234 (29%), Positives = 129/234 (55%), Gaps = 9/234 (3%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A K+++ + K + REI +L + HPH++ H +++ + ++ + ++ G+L
Sbjct: 45 VAIKIVNREKLSESVLMK-VEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGEL 103
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
++++++G + +AR + RQ+ A+ + H I HRD+K EN+LL N++++DFG A
Sbjct: 104 FDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMA 163
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
+ V L ET CGS Y PE+++G Y + DVWS G++++ +L A+PF+D
Sbjct: 164 SLQVGDSL----LETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDD 219
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEW 586
+++QL + K F + I +C+ L+ M E + RL + I W
Sbjct: 220 NLRQLLEKV--KRGVFHMPHF--IPPDCQSLLRGMSEVDAARRLTLEHIQKHIW 269
>AF533878-1|AAP97725.1| 674|Homo sapiens putative serine/threonine
protein kinase variant B2 protein.
Length = 674
Score = 151 bits (367), Expect = 6e-36
Identities = 82/264 (31%), Positives = 142/264 (53%), Gaps = 13/264 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L K +G+G V L + +A KI+ K + ++K + REI +L +
Sbjct: 19 YRLEKTLGKGQTGLVKLGVHCVTCQK----VAIKIVNREKLSESVLMK-VEREIAILKLI 73
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
HPH++ +H +++ K Y+ + + G+L Y++K G ++ +AR + RQ+ L + H
Sbjct: 74 EHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCH 133
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
I HRD+K EN+LL N++++DFG + V L ET CGS YA PE++RG
Sbjct: 134 SHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDS----LLETSCGSPHYACPEVIRG 189
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ Y + D+WS GV+LF +L ++PFDD +R+L E K R + + +C++
Sbjct: 190 EKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLE----KVKRGVFHMPHFIPPDCQS 245
Query: 259 VVKHLLEPDPGLRHSATNVLDSEW 282
+++ + E D R + ++ W
Sbjct: 246 LLRGMSEVDAARRLTLEHIQKHIW 269
Score = 135 bits (326), Expect = 5e-31
Identities = 69/234 (29%), Positives = 129/234 (55%), Gaps = 9/234 (3%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A K+++ + K + REI +L + HPH++ H +++ + ++ + ++ G+L
Sbjct: 45 VAIKIVNREKLSESVLMK-VEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGEL 103
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
++++++G + +AR + RQ+ A+ + H I HRD+K EN+LL N++++DFG A
Sbjct: 104 FDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMA 163
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
+ V L ET CGS Y PE+++G Y + DVWS G++++ +L A+PF+D
Sbjct: 164 SLQVGDSL----LETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDD 219
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEW 586
+++QL + K F + I +C+ L+ M E + RL + I W
Sbjct: 220 NLRQLLEKV--KRGVFHMPHF--IPPDCQSLLRGMSEVDAARRLTLEHIQKHIW 269
>AF533877-1|AAP97724.1| 674|Homo sapiens putative serine/threonine
protein kinase variant B1 protein.
Length = 674
Score = 151 bits (367), Expect = 6e-36
Identities = 82/264 (31%), Positives = 142/264 (53%), Gaps = 13/264 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L K +G+G V L + +A KI+ K + ++K + REI +L +
Sbjct: 19 YRLEKTLGKGQTGLVKLGVHCVTCQK----VAIKIVNREKLSESVLMK-VEREIAILKLI 73
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
HPH++ +H +++ K Y+ + + G+L Y++K G ++ +AR + RQ+ L + H
Sbjct: 74 EHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCH 133
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
I HRD+K EN+LL N++++DFG + V L ET CGS YA PE++RG
Sbjct: 134 SHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDS----LLETSCGSPHYACPEVIRG 189
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ Y + D+WS GV+LF +L ++PFDD +R+L E K R + + +C++
Sbjct: 190 EKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLE----KVKRGVFHMPHFIPPDCQS 245
Query: 259 VVKHLLEPDPGLRHSATNVLDSEW 282
+++ + E D R + ++ W
Sbjct: 246 LLRGMSEVDAARRLTLEHIQKHIW 269
Score = 135 bits (326), Expect = 5e-31
Identities = 69/234 (29%), Positives = 129/234 (55%), Gaps = 9/234 (3%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A K+++ + K + REI +L + HPH++ H +++ + ++ + ++ G+L
Sbjct: 45 VAIKIVNREKLSESVLMK-VEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGEL 103
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
++++++G + +AR + RQ+ A+ + H I HRD+K EN+LL N++++DFG A
Sbjct: 104 FDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMA 163
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
+ V L ET CGS Y PE+++G Y + DVWS G++++ +L A+PF+D
Sbjct: 164 SLQVGDSL----LETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDD 219
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEW 586
+++QL + K F + I +C+ L+ M E + RL + I W
Sbjct: 220 NLRQLLEKV--KRGVFHMPHF--IPPDCQSLLRGMSEVDAARRLTLEHIQKHIW 269
>AF533876-1|AAP97723.1| 668|Homo sapiens putative serine/threonine
protein kinase variant A protein.
Length = 668
Score = 151 bits (367), Expect = 6e-36
Identities = 82/264 (31%), Positives = 142/264 (53%), Gaps = 13/264 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L K +G+G V L + +A KI+ K + ++K + REI +L +
Sbjct: 19 YRLEKTLGKGQTGLVKLGVHCVTCQK----VAIKIVNREKLSESVLMK-VEREIAILKLI 73
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
HPH++ +H +++ K Y+ + + G+L Y++K G ++ +AR + RQ+ L + H
Sbjct: 74 EHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCH 133
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
I HRD+K EN+LL N++++DFG + V L ET CGS YA PE++RG
Sbjct: 134 SHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDS----LLETSCGSPHYACPEVIRG 189
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ Y + D+WS GV+LF +L ++PFDD +R+L E K R + + +C++
Sbjct: 190 EKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLE----KVKRGVFHMPHFIPPDCQS 245
Query: 259 VVKHLLEPDPGLRHSATNVLDSEW 282
+++ + E D R + ++ W
Sbjct: 246 LLRGMSEVDAARRLTLEHIQKHIW 269
Score = 135 bits (326), Expect = 5e-31
Identities = 69/234 (29%), Positives = 129/234 (55%), Gaps = 9/234 (3%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A K+++ + K + REI +L + HPH++ H +++ + ++ + ++ G+L
Sbjct: 45 VAIKIVNREKLSESVLMK-VEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGEL 103
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
++++++G + +AR + RQ+ A+ + H I HRD+K EN+LL N++++DFG A
Sbjct: 104 FDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMA 163
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
+ V L ET CGS Y PE+++G Y + DVWS G++++ +L A+PF+D
Sbjct: 164 SLQVGDSL----LETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDD 219
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEW 586
+++QL + K F + I +C+ L+ M E + RL + I W
Sbjct: 220 NLRQLLEKV--KRGVFHMPHF--IPPDCQSLLRGMSEVDAARRLTLEHIQKHIW 269
>AB058714-1|BAB47440.1| 715|Homo sapiens KIAA1811 protein protein.
Length = 715
Score = 151 bits (365), Expect = 1e-35
Identities = 73/230 (31%), Positives = 129/230 (56%), Gaps = 9/230 (3%)
Query: 53 IIETAKAPKDFVVKFLPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYI 112
I+ K + ++K + REI +L + HPH++ +H +++ K Y+ + + G+L Y+
Sbjct: 1 IVNREKLSESVLMK-VEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYL 59
Query: 113 LKNGCVSENQARVWTRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCV 172
+K G ++ +AR + RQ+ L + H I HRD+K EN+LL N++++DFG + V
Sbjct: 60 VKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASLQV 119
Query: 173 ESDNQPVLSETYCGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRK 232
L ET CGS YA PE+++G+ Y + D+WS GV+LF +L ++PFDD +R+
Sbjct: 120 GDS----LLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQ 175
Query: 233 LYEQQMGKKYRFRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEW 282
L E K R + + +C+++++ ++E +P R S + W
Sbjct: 176 LLE----KVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPW 221
Score = 136 bits (330), Expect = 2e-31
Identities = 65/213 (30%), Positives = 121/213 (56%), Gaps = 8/213 (3%)
Query: 374 REIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQ 433
REI +L + HPH++ H +++ + ++ + ++ G+L ++++++G + +AR + RQ
Sbjct: 17 REIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQ 76
Query: 434 LALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLS 493
+ A+ + H I HRD+K EN+LL N++++DFG A + V L ET CGS
Sbjct: 77 IVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSL----LETSCGSPH 132
Query: 494 YTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYI 553
Y PE+++G Y + D+WS G++++ +L A+PF+D +++QL + K F +
Sbjct: 133 YACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKV--KRGVFHMPHF 190
Query: 554 DTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEW 586
I +C+ L+ M+E + RL + I W
Sbjct: 191 --IPPDCQSLLRGMIEVEPEKRLSLEQIQKHPW 221
>AF159295-1|AAD48007.1| 752|Homo sapiens serine/threonine protein
kinase Kp78 splice variant CTAK75a protein.
Length = 752
Score = 150 bits (363), Expect = 2e-35
Identities = 89/289 (30%), Positives = 151/289 (52%), Gaps = 38/289 (13%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L K +G+G +AKV L + +A KII+ + + K RE+ ++ L
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGRE----VAIKIIDKTQLNPTSLQKLF-REVRIMKIL 110
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQ--------- 129
NHP+++ + + + + Y+ M Y G++ Y++ +G + E +AR RQ
Sbjct: 111 NHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGKMKEKEARSKFRQGCQAGQTIK 170
Query: 130 --------------LALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSR-FCVES 174
+ +QY H+ I HRD+K EN+LL A+ N+K++DFGFS F V
Sbjct: 171 VQVSFDLLSLMFTFIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGG 230
Query: 175 DNQPVLSETYCGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLY 234
+T+CGS YAAPE+ +GK Y D+WSLGV+L+ +++ S+PFD +++L
Sbjct: 231 K-----LDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELR 285
Query: 235 EQQMGKKYRFRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
E+ + KY R+ +S +C+ ++K L +P R + ++ WI
Sbjct: 286 ERVLRGKY----RIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 330
Score = 129 bits (312), Expect = 3e-29
Identities = 80/260 (30%), Positives = 136/260 (52%), Gaps = 36/260 (13%)
Query: 353 LACKVID-TSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
+A K+ID T P K F RE+ ++ L+HP++V + + ++ M Y G+
Sbjct: 82 VAIKIIDKTQLNPTSLQKLF--REVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGE 139
Query: 412 LLEFVLQRGAVQEDQARIWTRQ-----------------------LALAIQYMHELEIAH 448
+ ++++ G ++E +AR RQ + A+QY H+ I H
Sbjct: 140 VFDYLVAHGKMKEKEARSKFRQGCQAGQTIKVQVSFDLLSLMFTFIVSAVQYCHQKRIVH 199
Query: 449 RDIKCENVLLTANQNVKLSDFGFAR-MCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLP 507
RD+K EN+LL A+ N+K++DFGF+ V KL +TFCGS Y APE+ QG Y
Sbjct: 200 RDLKAENLLLDADMNIKIADFGFSNEFTVGGKL-----DTFCGSPPYAAPELFQGKKYDG 254
Query: 508 KPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLM 567
DVWSLG+++Y +++ ++PF+ +++K+L + + K+R + +S +C+ L+
Sbjct: 255 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVL--RGKYRIPFY--MSTDCENLLKRF 310
Query: 568 LEPNHQNRLKIYDIVNSEWI 587
L N R + I+ WI
Sbjct: 311 LVLNPIKRGTLEQIMKDRWI 330
>BC031231-1|AAH31231.1| 514|Homo sapiens serine/threonine kinase 33
protein.
Length = 514
Score = 149 bits (362), Expect = 2e-35
Identities = 89/283 (31%), Positives = 153/283 (54%), Gaps = 17/283 (6%)
Query: 10 EENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLP 69
E + + Y + +G+G++ V E + KE K A K + KA VK L
Sbjct: 107 ENGAAIEEIYTFGRILGKGSFGIVI--EATDKETETK--WAIKKVNKEKAGSS-AVKLLE 161
Query: 70 REIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQ 129
RE+++L + H H+IH+ +F+ K Y+ M E+G+L + + G SEN+ R +
Sbjct: 162 REVNILKSVKHEHIIHLEQVFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQS 221
Query: 130 LALGLQYLHELEIAHRDIKCENVLLTA---------NFNVKLSDFGFSRFCVESDNQPVL 180
LA + YLH +I HRD+K EN+++ + N N+K++DFG + +S ++ +L
Sbjct: 222 LASAIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLA-VKKQSRSEAML 280
Query: 181 SETYCGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGK 240
T CG+ Y APE++ Y + D+WS+GVV++++L PF + KL+E
Sbjct: 281 QAT-CGTPIYMAPEVISAHDY-SQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFELIRKG 338
Query: 241 KYRFRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+ F + V + +S K+V+K L++ DP R +A +LD++W+
Sbjct: 339 ELHFENAVWNSISDCAKSVLKQLMKVDPAHRITAKELLDNQWL 381
Score = 126 bits (303), Expect = 3e-28
Identities = 76/274 (27%), Positives = 139/274 (50%), Gaps = 16/274 (5%)
Query: 370 KFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARI 429
K L RE+ +L + H H++H +F+ K ++ M E G+L E + ++G E++ R
Sbjct: 158 KLLEREVNILKSVKHEHIIHLEQVFETPKKMYLVMELCEDGELKEILDRKGHFSENETRW 217
Query: 430 WTRQLALAIQYMHELEIAHRDIKCENVLLTA---------NQNVKLSDFGFARMCVDKKL 480
+ LA AI Y+H +I HRD+K EN+++ + N N+K++DFG A +
Sbjct: 218 IIQSLASAIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLA--VKKQSR 275
Query: 481 NEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQA 540
+E + CG+ Y APE++ Y + D+WS+G+V+Y++L PF ++L +
Sbjct: 276 SEAMLQATCGTPIYMAPEVISAHDY-SQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFEL 334
Query: 541 QINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRLLEWTPQE 600
F + ++ISD K ++ +++ + +R+ ++++++W+ ++L P
Sbjct: 335 IRKGELHFENAVWNSISDCAKSVLKQLMKVDPAHRITAKELLDNQWLT-GNKLSSVRPTN 393
Query: 601 TLAYKKAREEKNKLHKTVE-TVELPGSSKTEHKV 633
L K E KN E T E TE K+
Sbjct: 394 VLEMMK--EWKNNPESVEENTTEEKNKPSTEEKL 425
>AK093251-1|BAC04109.1| 514|Homo sapiens protein ( Homo sapiens
cDNA FLJ35932 fis, clone TESTI2011286, weakly similar to
MYOSIN LIGHT CHAIN KINASE (EC 2.7.1.117). ).
Length = 514
Score = 149 bits (362), Expect = 2e-35
Identities = 89/283 (31%), Positives = 153/283 (54%), Gaps = 17/283 (6%)
Query: 10 EENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLP 69
E + + Y + +G+G++ V E + KE K A K + KA VK L
Sbjct: 107 ENGAAIEEIYTFGRILGKGSFGIVI--EATDKETETK--WAIKKVNKEKAGSS-AVKLLE 161
Query: 70 REIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQ 129
RE+++L + H H+IH+ +F+ K Y+ M E+G+L + + G SEN+ R +
Sbjct: 162 REVNILKSVKHEHIIHLEQVFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQS 221
Query: 130 LALGLQYLHELEIAHRDIKCENVLLTA---------NFNVKLSDFGFSRFCVESDNQPVL 180
LA + YLH +I HRD+K EN+++ + N N+K++DFG + +S ++ +L
Sbjct: 222 LASAIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLA-VKKQSRSEAML 280
Query: 181 SETYCGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGK 240
T CG+ Y APE++ Y + D+WS+GVV++++L PF + KL+E
Sbjct: 281 QAT-CGTPIYMAPEVISAHDY-SQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFELIRKG 338
Query: 241 KYRFRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+ F + V + +S K+V+K L++ DP R +A +LD++W+
Sbjct: 339 ELHFENAVWNSISDCAKSVLKQLMKVDPAHRITAKELLDNQWL 381
Score = 126 bits (303), Expect = 3e-28
Identities = 76/274 (27%), Positives = 139/274 (50%), Gaps = 16/274 (5%)
Query: 370 KFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARI 429
K L RE+ +L + H H++H +F+ K ++ M E G+L E + ++G E++ R
Sbjct: 158 KLLEREVNILKSVKHEHIIHLEQVFETPKKMYLVMELCEDGELKEILDRKGHFSENETRW 217
Query: 430 WTRQLALAIQYMHELEIAHRDIKCENVLLTA---------NQNVKLSDFGFARMCVDKKL 480
+ LA AI Y+H +I HRD+K EN+++ + N N+K++DFG A +
Sbjct: 218 IIQSLASAIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLA--VKKQSR 275
Query: 481 NEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQA 540
+E + CG+ Y APE++ Y + D+WS+G+V+Y++L PF ++L +
Sbjct: 276 SEAMLQATCGTPIYMAPEVISAHDY-SQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFEL 334
Query: 541 QINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRLLEWTPQE 600
F + ++ISD K ++ +++ + +R+ ++++++W+ ++L P
Sbjct: 335 IRKGELHFENAVWNSISDCAKSVLKQLMKVDPAHRITAKELLDNQWLT-GNKLSSVRPTN 393
Query: 601 TLAYKKAREEKNKLHKTVE-TVELPGSSKTEHKV 633
L K E KN E T E TE K+
Sbjct: 394 VLEMMK--EWKNNPESVEENTTEEKNKPSTEEKL 425
>AJ303380-1|CAC29064.1| 514|Homo sapiens serine/threonine kinase 33
protein.
Length = 514
Score = 149 bits (362), Expect = 2e-35
Identities = 89/283 (31%), Positives = 153/283 (54%), Gaps = 17/283 (6%)
Query: 10 EENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLP 69
E + + Y + +G+G++ V E + KE K A K + KA VK L
Sbjct: 107 ENGAAIEEIYTFGRILGKGSFGIVI--EATDKETETK--WAIKKVNKEKAGSS-AVKLLE 161
Query: 70 REIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQ 129
RE+++L + H H+IH+ +F+ K Y+ M E+G+L + + G SEN+ R +
Sbjct: 162 REVNILKSVKHEHIIHLEQVFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQS 221
Query: 130 LALGLQYLHELEIAHRDIKCENVLLTA---------NFNVKLSDFGFSRFCVESDNQPVL 180
LA + YLH +I HRD+K EN+++ + N N+K++DFG + +S ++ +L
Sbjct: 222 LASAIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLA-VKKQSRSEAML 280
Query: 181 SETYCGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGK 240
T CG+ Y APE++ Y + D+WS+GVV++++L PF + KL+E
Sbjct: 281 QAT-CGTPIYMAPEVISAHDY-SQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFELIRKG 338
Query: 241 KYRFRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+ F + V + +S K+V+K L++ DP R +A +LD++W+
Sbjct: 339 ELHFENAVWNSISDCAKSVLKQLMKVDPAHRITAKELLDNQWL 381
Score = 126 bits (303), Expect = 3e-28
Identities = 76/274 (27%), Positives = 139/274 (50%), Gaps = 16/274 (5%)
Query: 370 KFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARI 429
K L RE+ +L + H H++H +F+ K ++ M E G+L E + ++G E++ R
Sbjct: 158 KLLEREVNILKSVKHEHIIHLEQVFETPKKMYLVMELCEDGELKEILDRKGHFSENETRW 217
Query: 430 WTRQLALAIQYMHELEIAHRDIKCENVLLTA---------NQNVKLSDFGFARMCVDKKL 480
+ LA AI Y+H +I HRD+K EN+++ + N N+K++DFG A +
Sbjct: 218 IIQSLASAIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLA--VKKQSR 275
Query: 481 NEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQA 540
+E + CG+ Y APE++ Y + D+WS+G+V+Y++L PF ++L +
Sbjct: 276 SEAMLQATCGTPIYMAPEVISAHDY-SQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFEL 334
Query: 541 QINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRLLEWTPQE 600
F + ++ISD K ++ +++ + +R+ ++++++W+ ++L P
Sbjct: 335 IRKGELHFENAVWNSISDCAKSVLKQLMKVDPAHRITAKELLDNQWLT-GNKLSSVRPTN 393
Query: 601 TLAYKKAREEKNKLHKTVE-TVELPGSSKTEHKV 633
L K E KN E T E TE K+
Sbjct: 394 VLEMMK--EWKNNPESVEENTTEEKNKPSTEEKL 425
>AJ271722-1|CAB71146.1| 714|Homo sapiens putative serine/threonine
protein kinase MAK-V protein.
Length = 714
Score = 148 bits (359), Expect = 5e-35
Identities = 91/265 (34%), Positives = 146/265 (55%), Gaps = 18/265 (6%)
Query: 25 VGEGAYAKVYLTEYSSKEDSHKST---LACKIIETAKAPKD-FVVKFLPREIDVLVRLNH 80
+GEG++AKV +E H T +A K+I+ +A KD +V K L RE + + H
Sbjct: 68 LGEGSFAKV-------REGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRH 120
Query: 81 PHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLHEL 140
P++ + I + + YY+ M G+L+ I + + E++AR + RQL +++LH
Sbjct: 121 PNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRA 180
Query: 141 EIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRGKP 200
+ HRD+K EN+LL + N+KL DFG S C T CGS +YAAPE+L K
Sbjct: 181 GVVHRDLKIENLLLDEDNNIKLIDFGLSN-CAGILGYSDPFSTQCGSPAYAAPELLARKK 239
Query: 201 YCPKPTDLWSLGVVLFVMLNKSMPF--DDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
Y PK D+WS+GV ++ ML ++PF + +R LY++ + K+ + + + LS +
Sbjct: 240 YGPK-IDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKE---MNPLPTQLSTGAIS 295
Query: 259 VVKHLLEPDPGLRHSATNVLDSEWI 283
++ LLEPDP R + L + W+
Sbjct: 296 FLRSLLEPDPVKRPNIQQALANRWL 320
Score = 131 bits (317), Expect = 7e-30
Identities = 88/286 (30%), Positives = 145/286 (50%), Gaps = 16/286 (5%)
Query: 307 RRKLSDVHKHPPKRQGDILEGPTR--ESAFRVYLAEYRNASKNDKLSILACKVIDTSTAP 364
R +L D H KR G+ L G + E +F + E + +K++I KVID A
Sbjct: 46 RERLRDFQHH--KRVGNYLIGSRKLGEGSF-AKVREGLHVLTGEKVAI---KVIDKKRAK 99
Query: 365 RD-FVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQ 423
+D +V K L RE ++ + HP++ I + Y++ M G+L+ + ++ ++
Sbjct: 100 KDTYVTKNLRREGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLE 159
Query: 424 EDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEI 483
E +AR + RQL A++++H + HRD+K EN+LL + N+KL DFG + C
Sbjct: 160 ESEARRYIRQLISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSN-CAGILGYSD 218
Query: 484 RSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPF--EDKHIKQLHQAQ 541
T CGS +Y APE+L Y PK DVWS+G+ +Y ML +PF E ++ L+Q
Sbjct: 219 PFSTQCGSPAYAAPELLARKKYGPK-IDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKM 277
Query: 542 INKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
++K + +S + +LEP+ R I + + W+
Sbjct: 278 VDKE---MNPLPTQLSTGAISFLRSLLEPDPVKRPNIQQALANRWL 320
>BC032787-1|AAH32787.1| 476|Homo sapiens
calcium/calmodulin-dependent protein kinase IG protein.
Length = 476
Score = 148 bits (358), Expect = 7e-35
Identities = 90/277 (32%), Positives = 143/277 (51%), Gaps = 16/277 (5%)
Query: 10 EENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLP 69
++ T + K + + +G GA+++V+L K+ A K I+ + A +D L
Sbjct: 14 KQTTNIRKTFIFMEVLGSGAFSEVFLV----KQRLTGKLFALKCIKKSPAFRD---SSLE 66
Query: 70 REIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQ 129
EI VL ++ H +++ + I++ T YY+ M+ G+L IL+ G +E A + +Q
Sbjct: 67 NEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQ 126
Query: 130 LALGLQYLHELEIAHRDIKCENVL-LT--ANFNVKLSDFGFSRFCVESDNQPVLSETYCG 186
+ ++YLHE I HRD+K EN+L LT N + ++DFG S+ Q + T CG
Sbjct: 127 VLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKM-----EQNGIMSTACG 181
Query: 187 SMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRS 246
+ Y APE+L KPY K D WS+GV+ +++L PF + KL+E+ Y F S
Sbjct: 182 TPGYVAPEVLAQKPY-SKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFES 240
Query: 247 RVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+S K + HLLE DP R++ L WI
Sbjct: 241 PFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWI 277
Score = 130 bits (313), Expect = 2e-29
Identities = 80/239 (33%), Positives = 129/239 (53%), Gaps = 12/239 (5%)
Query: 352 ILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
+ A K I S A RD L EI +L K+ H ++V I++ Y++ M+ + G+
Sbjct: 48 LFALKCIKKSPAFRD---SSLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGE 104
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVL-LTANQNVK--LSD 468
L + +L+RG E A + +Q+ A++Y+HE I HRD+K EN+L LT +N K ++D
Sbjct: 105 LFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITD 164
Query: 469 FGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMP 528
FG ++M + N I S T CG+ Y APE+L PY K D WS+G++ Y++L P
Sbjct: 165 FGLSKM----EQNGIMS-TACGTPGYVAPEVLAQKPY-SKAVDCWSIGVITYILLCGYPP 218
Query: 529 FEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
F ++ +L + ++F S + D IS++ K I +LE + R ++ WI
Sbjct: 219 FYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWI 277
>AY212935-1|AAP29964.1| 460|Homo sapiens CLICK III protein.
Length = 460
Score = 148 bits (358), Expect = 7e-35
Identities = 90/277 (32%), Positives = 143/277 (51%), Gaps = 16/277 (5%)
Query: 10 EENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLP 69
++ T + K + + +G GA+++V+L K+ A K I+ + A +D L
Sbjct: 14 KQTTNIRKTFIFMEVLGSGAFSEVFLV----KQRLTGKLFALKCIKKSPAFRD---SSLE 66
Query: 70 REIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQ 129
EI VL ++ H +++ + I++ T YY+ M+ G+L IL+ G +E A + +Q
Sbjct: 67 NEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQ 126
Query: 130 LALGLQYLHELEIAHRDIKCENVL-LT--ANFNVKLSDFGFSRFCVESDNQPVLSETYCG 186
+ ++YLHE I HRD+K EN+L LT N + ++DFG S+ Q + T CG
Sbjct: 127 VLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKM-----EQNGIMSTACG 181
Query: 187 SMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRS 246
+ Y APE+L KPY K D WS+GV+ +++L PF + KL+E+ Y F S
Sbjct: 182 TPGYVAPEVLAQKPY-SKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFES 240
Query: 247 RVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+S K + HLLE DP R++ L WI
Sbjct: 241 PFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWI 277
Score = 130 bits (313), Expect = 2e-29
Identities = 80/239 (33%), Positives = 129/239 (53%), Gaps = 12/239 (5%)
Query: 352 ILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
+ A K I S A RD L EI +L K+ H ++V I++ Y++ M+ + G+
Sbjct: 48 LFALKCIKKSPAFRD---SSLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGE 104
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVL-LTANQNVK--LSD 468
L + +L+RG E A + +Q+ A++Y+HE I HRD+K EN+L LT +N K ++D
Sbjct: 105 LFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITD 164
Query: 469 FGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMP 528
FG ++M + N I S T CG+ Y APE+L PY K D WS+G++ Y++L P
Sbjct: 165 FGLSKM----EQNGIMS-TACGTPGYVAPEVLAQKPY-SKAVDCWSIGVITYILLCGYPP 218
Query: 529 FEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
F ++ +L + ++F S + D IS++ K I +LE + R ++ WI
Sbjct: 219 FYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWI 277
>AL049688-1|CAB41259.1| 481|Homo sapiens hypothetical protein
protein.
Length = 481
Score = 148 bits (358), Expect = 7e-35
Identities = 90/277 (32%), Positives = 143/277 (51%), Gaps = 16/277 (5%)
Query: 10 EENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLP 69
++ T + K + + +G GA+++V+L K+ A K I+ + A +D L
Sbjct: 19 KQTTNIRKTFIFMEVLGSGAFSEVFLV----KQRLTGKLFALKCIKKSPAFRD---SSLE 71
Query: 70 REIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQ 129
EI VL ++ H +++ + I++ T YY+ M+ G+L IL+ G +E A + +Q
Sbjct: 72 NEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQ 131
Query: 130 LALGLQYLHELEIAHRDIKCENVL-LT--ANFNVKLSDFGFSRFCVESDNQPVLSETYCG 186
+ ++YLHE I HRD+K EN+L LT N + ++DFG S+ Q + T CG
Sbjct: 132 VLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKM-----EQNGIMSTACG 186
Query: 187 SMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRS 246
+ Y APE+L KPY K D WS+GV+ +++L PF + KL+E+ Y F S
Sbjct: 187 TPGYVAPEVLAQKPY-SKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFES 245
Query: 247 RVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+S K + HLLE DP R++ L WI
Sbjct: 246 PFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWI 282
Score = 130 bits (313), Expect = 2e-29
Identities = 80/239 (33%), Positives = 129/239 (53%), Gaps = 12/239 (5%)
Query: 352 ILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
+ A K I S A RD L EI +L K+ H ++V I++ Y++ M+ + G+
Sbjct: 53 LFALKCIKKSPAFRD---SSLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGE 109
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVL-LTANQNVK--LSD 468
L + +L+RG E A + +Q+ A++Y+HE I HRD+K EN+L LT +N K ++D
Sbjct: 110 LFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITD 169
Query: 469 FGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMP 528
FG ++M + N I S T CG+ Y APE+L PY K D WS+G++ Y++L P
Sbjct: 170 FGLSKM----EQNGIMS-TACGTPGYVAPEVLAQKPY-SKAVDCWSIGVITYILLCGYPP 223
Query: 529 FEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
F ++ +L + ++F S + D IS++ K I +LE + R ++ WI
Sbjct: 224 FYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWI 282
>AL023754-3|CAI19991.1| 476|Homo sapiens
calcium/calmodulin-dependent protein kinase IG protein.
Length = 476
Score = 148 bits (358), Expect = 7e-35
Identities = 90/277 (32%), Positives = 143/277 (51%), Gaps = 16/277 (5%)
Query: 10 EENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLP 69
++ T + K + + +G GA+++V+L K+ A K I+ + A +D L
Sbjct: 14 KQTTNIRKTFIFMEVLGSGAFSEVFLV----KQRLTGKLFALKCIKKSPAFRD---SSLE 66
Query: 70 REIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQ 129
EI VL ++ H +++ + I++ T YY+ M+ G+L IL+ G +E A + +Q
Sbjct: 67 NEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQ 126
Query: 130 LALGLQYLHELEIAHRDIKCENVL-LT--ANFNVKLSDFGFSRFCVESDNQPVLSETYCG 186
+ ++YLHE I HRD+K EN+L LT N + ++DFG S+ Q + T CG
Sbjct: 127 VLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKM-----EQNGIMSTACG 181
Query: 187 SMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRS 246
+ Y APE+L KPY K D WS+GV+ +++L PF + KL+E+ Y F S
Sbjct: 182 TPGYVAPEVLAQKPY-SKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFES 240
Query: 247 RVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+S K + HLLE DP R++ L WI
Sbjct: 241 PFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWI 277
Score = 130 bits (313), Expect = 2e-29
Identities = 80/239 (33%), Positives = 129/239 (53%), Gaps = 12/239 (5%)
Query: 352 ILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
+ A K I S A RD L EI +L K+ H ++V I++ Y++ M+ + G+
Sbjct: 48 LFALKCIKKSPAFRD---SSLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGE 104
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVL-LTANQNVK--LSD 468
L + +L+RG E A + +Q+ A++Y+HE I HRD+K EN+L LT +N K ++D
Sbjct: 105 LFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITD 164
Query: 469 FGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMP 528
FG ++M + N I S T CG+ Y APE+L PY K D WS+G++ Y++L P
Sbjct: 165 FGLSKM----EQNGIMS-TACGTPGYVAPEVLAQKPY-SKAVDCWSIGVITYILLCGYPP 218
Query: 529 FEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
F ++ +L + ++F S + D IS++ K I +LE + R ++ WI
Sbjct: 219 FYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWI 277
>AF428261-1|AAL28100.1| 476|Homo sapiens
calcium/calmodulin-dependent protein kinase I gamma
protein.
Length = 476
Score = 148 bits (358), Expect = 7e-35
Identities = 90/277 (32%), Positives = 143/277 (51%), Gaps = 16/277 (5%)
Query: 10 EENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLP 69
++ T + K + + +G GA+++V+L K+ A K I+ + A +D L
Sbjct: 14 KQTTNIRKTFIFMEVLGSGAFSEVFLV----KQRLTGKLFALKCIKKSPAFRD---SSLE 66
Query: 70 REIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQ 129
EI VL ++ H +++ + I++ T YY+ M+ G+L IL+ G +E A + +Q
Sbjct: 67 NEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQ 126
Query: 130 LALGLQYLHELEIAHRDIKCENVL-LT--ANFNVKLSDFGFSRFCVESDNQPVLSETYCG 186
+ ++YLHE I HRD+K EN+L LT N + ++DFG S+ Q + T CG
Sbjct: 127 VLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKM-----EQNGIMSTACG 181
Query: 187 SMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRS 246
+ Y APE+L KPY K D WS+GV+ +++L PF + KL+E+ Y F S
Sbjct: 182 TPGYVAPEVLAQKPY-SKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFES 240
Query: 247 RVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+S K + HLLE DP R++ L WI
Sbjct: 241 PFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWI 277
Score = 130 bits (313), Expect = 2e-29
Identities = 80/239 (33%), Positives = 129/239 (53%), Gaps = 12/239 (5%)
Query: 352 ILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
+ A K I S A RD L EI +L K+ H ++V I++ Y++ M+ + G+
Sbjct: 48 LFALKCIKKSPAFRD---SSLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGE 104
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVL-LTANQNVK--LSD 468
L + +L+RG E A + +Q+ A++Y+HE I HRD+K EN+L LT +N K ++D
Sbjct: 105 LFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITD 164
Query: 469 FGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMP 528
FG ++M + N I S T CG+ Y APE+L PY K D WS+G++ Y++L P
Sbjct: 165 FGLSKM----EQNGIMS-TACGTPGYVAPEVLAQKPY-SKAVDCWSIGVITYILLCGYPP 218
Query: 529 FEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
F ++ +L + ++F S + D IS++ K I +LE + R ++ WI
Sbjct: 219 FYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWI 277
>L41816-1|AAA99458.1| 370|Homo sapiens cam kinase I protein.
Length = 370
Score = 146 bits (354), Expect = 2e-34
Identities = 92/274 (33%), Positives = 141/274 (51%), Gaps = 14/274 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y +G GA+++V L E + + +A K I AK + + EI VL ++
Sbjct: 20 YDFRDVLGTGAFSEVILAE----DKRTQKLVAIKCI--AKEALEGKEGSMENEIAVLHKI 73
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
HP+++ + I++ Y+ M+ G+L I++ G +E A Q+ ++YLH
Sbjct: 74 KHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLH 133
Query: 139 ELEIAHRDIKCENVL---LTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEI 195
+L I HRD+K EN+L L + + +SDFG S+ D VLS T CG+ Y APE+
Sbjct: 134 DLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKM---EDPGSVLS-TACGTPGYVAPEV 189
Query: 196 LRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLE 255
L KPY K D WS+GV+ +++L PF D KL+EQ + +Y F S +S
Sbjct: 190 LAQKPYS-KAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDS 248
Query: 256 CKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRL 289
K ++HL+E DP R + L WIA D+ L
Sbjct: 249 AKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTAL 282
Score = 129 bits (311), Expect = 3e-29
Identities = 71/225 (31%), Positives = 123/225 (54%), Gaps = 8/225 (3%)
Query: 372 LPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWT 431
+ EI +L K+ HP++V I++ ++ M+ + G+L + ++++G E A
Sbjct: 63 MENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLI 122
Query: 432 RQLALAIQYMHELEIAHRDIKCENVL---LTANQNVKLSDFGFARMCVDKKLNEIRSETF 488
Q+ A++Y+H+L I HRD+K EN+L L + + +SDFG ++M + + S T
Sbjct: 123 FQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKM---EDPGSVLS-TA 178
Query: 489 CGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKF 548
CG+ Y APE+L PY K D WS+G++ Y++L PF D++ +L + + ++F
Sbjct: 179 CGTPGYVAPEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEF 237
Query: 549 RSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRL 593
S Y D ISD+ K I ++E + + R + WIA D+ L
Sbjct: 238 DSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTAL 282
>BC106755-1|AAI06756.1| 370|Homo sapiens
calcium/calmodulin-dependent protein kinase I protein.
Length = 370
Score = 146 bits (354), Expect = 2e-34
Identities = 92/274 (33%), Positives = 141/274 (51%), Gaps = 14/274 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y +G GA+++V L E + + +A K I AK + + EI VL ++
Sbjct: 20 YDFRDVLGTGAFSEVILAE----DKRTQKLVAIKCI--AKEALEGKEGSMENEIAVLHKI 73
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
HP+++ + I++ Y+ M+ G+L I++ G +E A Q+ ++YLH
Sbjct: 74 KHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLH 133
Query: 139 ELEIAHRDIKCENVL---LTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEI 195
+L I HRD+K EN+L L + + +SDFG S+ D VLS T CG+ Y APE+
Sbjct: 134 DLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKM---EDPGSVLS-TACGTPGYVAPEV 189
Query: 196 LRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLE 255
L KPY K D WS+GV+ +++L PF D KL+EQ + +Y F S +S
Sbjct: 190 LAQKPYS-KAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDS 248
Query: 256 CKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRL 289
K ++HL+E DP R + L WIA D+ L
Sbjct: 249 AKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTAL 282
Score = 129 bits (311), Expect = 3e-29
Identities = 71/225 (31%), Positives = 123/225 (54%), Gaps = 8/225 (3%)
Query: 372 LPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWT 431
+ EI +L K+ HP++V I++ ++ M+ + G+L + ++++G E A
Sbjct: 63 MENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLI 122
Query: 432 RQLALAIQYMHELEIAHRDIKCENVL---LTANQNVKLSDFGFARMCVDKKLNEIRSETF 488
Q+ A++Y+H+L I HRD+K EN+L L + + +SDFG ++M + + S T
Sbjct: 123 FQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKM---EDPGSVLS-TA 178
Query: 489 CGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKF 548
CG+ Y APE+L PY K D WS+G++ Y++L PF D++ +L + + ++F
Sbjct: 179 CGTPGYVAPEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEF 237
Query: 549 RSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRL 593
S Y D ISD+ K I ++E + + R + WIA D+ L
Sbjct: 238 DSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTAL 282
>BC106754-1|AAI06755.1| 370|Homo sapiens
calcium/calmodulin-dependent protein kinase I protein.
Length = 370
Score = 146 bits (354), Expect = 2e-34
Identities = 92/274 (33%), Positives = 141/274 (51%), Gaps = 14/274 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y +G GA+++V L E + + +A K I AK + + EI VL ++
Sbjct: 20 YDFRDVLGTGAFSEVILAE----DKRTQKLVAIKCI--AKEALEGKEGSMENEIAVLHKI 73
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
HP+++ + I++ Y+ M+ G+L I++ G +E A Q+ ++YLH
Sbjct: 74 KHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLH 133
Query: 139 ELEIAHRDIKCENVL---LTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEI 195
+L I HRD+K EN+L L + + +SDFG S+ D VLS T CG+ Y APE+
Sbjct: 134 DLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKM---EDPGSVLS-TACGTPGYVAPEV 189
Query: 196 LRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLE 255
L KPY K D WS+GV+ +++L PF D KL+EQ + +Y F S +S
Sbjct: 190 LAQKPYS-KAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDS 248
Query: 256 CKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRL 289
K ++HL+E DP R + L WIA D+ L
Sbjct: 249 AKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTAL 282
Score = 129 bits (311), Expect = 3e-29
Identities = 71/225 (31%), Positives = 123/225 (54%), Gaps = 8/225 (3%)
Query: 372 LPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWT 431
+ EI +L K+ HP++V I++ ++ M+ + G+L + ++++G E A
Sbjct: 63 MENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLI 122
Query: 432 RQLALAIQYMHELEIAHRDIKCENVL---LTANQNVKLSDFGFARMCVDKKLNEIRSETF 488
Q+ A++Y+H+L I HRD+K EN+L L + + +SDFG ++M + + S T
Sbjct: 123 FQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKM---EDPGSVLS-TA 178
Query: 489 CGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKF 548
CG+ Y APE+L PY K D WS+G++ Y++L PF D++ +L + + ++F
Sbjct: 179 CGTPGYVAPEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEF 237
Query: 549 RSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRL 593
S Y D ISD+ K I ++E + + R + WIA D+ L
Sbjct: 238 DSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTAL 282
>BC036422-1|AAH36422.1| 436|Homo sapiens hypothetical protein
MGC42105 protein.
Length = 436
Score = 143 bits (346), Expect = 2e-33
Identities = 80/265 (30%), Positives = 145/265 (54%), Gaps = 13/265 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y++ +G G +++V L +S K +A KI++ K + + L REI + +L
Sbjct: 74 YRIRGEIGSGNFSQVKLGIHSLT----KEKVAIKILDKTKLDQK-TQRLLSREISSMEKL 128
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
+HP++I ++ + + +K ++ M Y G+L I G +SE ++++ Q+ ++++H
Sbjct: 129 HHPNIIRLYEVVETLSKLHLVMEYAGGGELFGKISTEGKLSEPESKLIFSQIVSAVKHMH 188
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
E +I HRD+K ENV T+N VK+ DFGFS + + + T+CGS YAAPE+ R
Sbjct: 189 ENQIIHRDLKAENVFYTSNTCVKVGDFGFSTVSKKGE----MLNTFCGSPPYAAPELFRD 244
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ Y D+W+LGV+L+ M+ +MPF + KL + + Y V +S C
Sbjct: 245 EHYIGIYVDIWALGVLLYFMVTGTMPFRAETVAKLKKSILEGTY----SVPPHVSEPCHR 300
Query: 259 VVKHLLEPDPGLRHSATNVLDSEWI 283
+++ +L+ P R+ +++ EW+
Sbjct: 301 LIRGVLQQIPTERYGIDCIMNDEWM 325
Score = 138 bits (333), Expect = 8e-32
Identities = 81/272 (29%), Positives = 143/272 (52%), Gaps = 14/272 (5%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A K++D + + ++ L REI + KL HP+++ + + + K + M Y G+L
Sbjct: 100 VAIKILDKTKLDQK-TQRLLSREISSMEKLHHPNIIRLYEVVETLSKLHLVMEYAGGGEL 158
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
+ G + E ++++ Q+ A+++MHE +I HRD+K ENV T+N VK+ DFGF+
Sbjct: 159 FGKISTEGKLSEPESKLIFSQIVSAVKHMHENQIIHRDLKAENVFYTSNTCVKVGDFGFS 218
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
V KK + TFCGS Y APE+ + Y+ D+W+LG+++Y M+ MPF +
Sbjct: 219 --TVSKKGEML--NTFCGSPPYAAPELFRDEHYIGIYVDIWALGVLLYFMVTGTMPFRAE 274
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEW---IAM 589
+ +L ++ + + +S+ C RLI +L+ R I I+N EW +
Sbjct: 275 TVAKLKKSILEGTYSVPPH----VSEPCHRLIRGVLQQIPTERYGIDCIMNDEWMQGVPY 330
Query: 590 DSRL--LEWTPQETLAYKKAREEKNKLHKTVE 619
+ L + P+ +EE+N++ T+E
Sbjct: 331 PTPLEPFQLDPKHLSETSTLKEEENEVKSTLE 362
>BC048980-1|AAH48980.1| 574|Homo sapiens protein kinase,
AMP-activated, alpha 1 catalytic subunit protein.
Length = 574
Score = 142 bits (344), Expect = 4e-33
Identities = 93/284 (32%), Positives = 144/284 (50%), Gaps = 29/284 (10%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y L +G G + KV + ++ HK +A KI+ K VV + REI L
Sbjct: 27 YILGDTLGVGTFGKVKVGKHELT--GHK--VAVKILNRQKIRSLDVVGKIRREIQNLKLF 82
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVS---------------ENQA 123
HPH+I ++ + + ++ M Y G+L YI KNG S E ++
Sbjct: 83 RHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKES 142
Query: 124 RVWTRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSET 183
R +Q+ G+ Y H + HRD+K ENVLL A+ N K++DFG S SD + T
Sbjct: 143 RRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM--SDGE--FLRT 198
Query: 184 YCGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQM-GKKY 242
CGS +YAAPE++ G+ Y D+WS GV+L+ +L ++PFDD + L+++ G Y
Sbjct: 199 SCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFY 258
Query: 243 RFRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMD 286
+ S++SL +KH+L+ DP R + ++ + EW D
Sbjct: 259 TPQYLNPSVISL-----LKHMLQVDPMKRATIKDIREHEWFKQD 297
Score = 118 bits (285), Expect = 5e-26
Identities = 77/272 (28%), Positives = 129/272 (47%), Gaps = 26/272 (9%)
Query: 366 DFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGA---- 421
D V K + REI+ L HPH++ + + F+ M Y+ G+L +++ + G
Sbjct: 67 DVVGK-IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDV 125
Query: 422 -----------VQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFG 470
+ E ++R +Q+ + Y H + HRD+K ENVLL A+ N K++DFG
Sbjct: 126 PGVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFG 185
Query: 471 FARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
+ M D + T CGS +Y APE++ G Y D+WS G+++Y +L +PF+
Sbjct: 186 LSNMMSDGEF----LRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFD 241
Query: 531 DKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMD 590
D H+ L + +I + +Y ++ + L+ ML+ + R I DI EW D
Sbjct: 242 DDHVPTLFK-KICDGIFYTPQY---LNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQD 297
Query: 591 SRLLEWTPQETLAYKKAREEKNKLHKTVETVE 622
L ++ E +Y + L + E E
Sbjct: 298 --LPKYLFPEDPSYSSTMIDDEALKEVCEKFE 327
>BC062616-1|AAH62616.1| 424|Homo sapiens protein serine kinase H1
protein.
Length = 424
Score = 140 bits (340), Expect = 1e-32
Identities = 89/296 (30%), Positives = 150/296 (50%), Gaps = 17/296 (5%)
Query: 15 LTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDV 74
+T Y + +G G++++V E+ + + A K+IET V + E+ V
Sbjct: 94 VTAKYDIKALIGRGSFSRVVRVEHRATRQPY----AIKMIETKYREGREVCE---SELRV 146
Query: 75 LVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGL 134
L R+ H ++I + +F+ + + Y+ M G+L I+ G +E A + + G+
Sbjct: 147 LRRVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGV 206
Query: 135 QYLHELEIAHRDIKCENVLL---TANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYA 191
+YLH L I HRD+K EN+L + + ++DFG + + D+ L +T CG+ Y
Sbjct: 207 RYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDD--CLMKTTCGTPEYI 264
Query: 192 APEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASI 251
APE+L KPY D+W+LGV+ +++L+ +MPF+D +LY Q + KY +
Sbjct: 265 APEVLVRKPY-TNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPS 323
Query: 252 LSLECKTVVKHLLEPDPGLRHSATNVLDSEWI---AMDSRLTTLN-AVEAAALKRA 303
+S K + LL DPG R +A L W+ A S + L+ ++ LKRA
Sbjct: 324 VSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRA 379
Score = 106 bits (255), Expect = 2e-22
Identities = 55/216 (25%), Positives = 112/216 (51%), Gaps = 6/216 (2%)
Query: 375 EIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQL 434
E+ +L ++ H +++ +F+ + + ++ M G+L + ++ +G+ E A + +
Sbjct: 143 ELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMV 202
Query: 435 ALAIQYMHELEIAHRDIKCENVLL---TANQNVKLSDFGFARMCVDKKLNEIRSETFCGS 491
++Y+H L I HRD+K EN+L + + ++DFG A KK ++ +T CG+
Sbjct: 203 LDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLA--SARKKGDDCLMKTTCGT 260
Query: 492 LSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSR 551
Y APE+L PY D+W+LG++ Y++L+ MPFED + +L++ + + +
Sbjct: 261 PEYIAPEVLVRKPY-TNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGE 319
Query: 552 YIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
++S+ K I +L + R+ + W+
Sbjct: 320 PWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPWV 355
>AL592406-2|CAH72462.1| 758|Homo sapiens MAP/microtubule
affinity-regulating kinase 1 protein.
Length = 758
Score = 140 bits (340), Expect = 1e-32
Identities = 84/265 (31%), Positives = 141/265 (53%), Gaps = 35/265 (13%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L K +G+G +AKV L + +A KII+ + + K RE+ ++ L
Sbjct: 60 YRLQKTIGKGNFAKVKLARHVLTGRE----VAVKIIDKTQLNPTSLQKLF-REVRIMKIL 114
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP++ G++ Y++ +G + E +AR RQ+ +QY H
Sbjct: 115 NHPNI----------------------GEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 152
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
+ I HRD+K EN+LL + N+K++DFGFS + +T+CGS YAAPE+ +G
Sbjct: 153 QKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKL----DTFCGSPPYAAPELFQG 208
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
K Y D+WSLGV+L+ +++ S+PFD +++L E+ + KY R+ +S +C+
Sbjct: 209 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY----RIPFYMSTDCEN 264
Query: 259 VVKHLLEPDPGLRHSATNVLDSEWI 283
++K LL +P R S ++ W+
Sbjct: 265 LLKKLLVLNPIKRGSLEQIMKDRWM 289
Score = 126 bits (305), Expect = 2e-28
Identities = 78/269 (28%), Positives = 144/269 (53%), Gaps = 19/269 (7%)
Query: 328 PTRESAFRVYLAEYRNA--SKNDKLSILACKVIDTSTAPRDFVKKFLPREI----EMLIK 381
PT+ S+ R + RN+ S D+ + + + +F K L R + E+ +K
Sbjct: 31 PTKSSS-RQNIPRCRNSITSATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVK 89
Query: 382 LSHPHLVHTHSIFQ--RRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQ 439
+ ++ S+ + R + + + G++ ++++ G ++E +AR RQ+ A+Q
Sbjct: 90 IIDKTQLNPTSLQKLFREVRIMKILNHPNIGEVFDYLVAHGRMKEKEARAKFRQIVSAVQ 149
Query: 440 YMHELEIAHRDIKCENVLLTANQNVKLSDFGFA-RMCVDKKLNEIRSETFCGSLSYTAPE 498
Y H+ I HRD+K EN+LL + N+K++DFGF+ V KL +TFCGS Y APE
Sbjct: 150 YCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKL-----DTFCGSPPYAAPE 204
Query: 499 ILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISD 558
+ QG Y DVWSLG+++Y +++ ++PF+ +++K+L + + K+R + +S
Sbjct: 205 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVL--RGKYRIPFY--MST 260
Query: 559 NCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+C+ L+ +L N R + I+ W+
Sbjct: 261 DCENLLKKLLVLNPIKRGSLEQIMKDRWM 289
>AJ272212-1|CAB91984.1| 424|Homo sapiens protein serine kinase
protein.
Length = 424
Score = 140 bits (340), Expect = 1e-32
Identities = 89/296 (30%), Positives = 150/296 (50%), Gaps = 17/296 (5%)
Query: 15 LTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDV 74
+T Y + +G G++++V E+ + + A K+IET V + E+ V
Sbjct: 94 VTAKYDIKALIGRGSFSRVVRVEHRATRQPY----AIKMIETKYREGREVCE---SELRV 146
Query: 75 LVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGL 134
L R+ H ++I + +F+ + + Y+ M G+L I+ G +E A + + G+
Sbjct: 147 LRRVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGV 206
Query: 135 QYLHELEIAHRDIKCENVLL---TANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYA 191
+YLH L I HRD+K EN+L + + ++DFG + + D+ L +T CG+ Y
Sbjct: 207 RYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDD--CLMKTTCGTPEYI 264
Query: 192 APEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASI 251
APE+L KPY D+W+LGV+ +++L+ +MPF+D +LY Q + KY +
Sbjct: 265 APEVLVRKPY-TNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPS 323
Query: 252 LSLECKTVVKHLLEPDPGLRHSATNVLDSEWI---AMDSRLTTLN-AVEAAALKRA 303
+S K + LL DPG R +A L W+ A S + L+ ++ LKRA
Sbjct: 324 VSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRA 379
Score = 106 bits (255), Expect = 2e-22
Identities = 55/216 (25%), Positives = 112/216 (51%), Gaps = 6/216 (2%)
Query: 375 EIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQL 434
E+ +L ++ H +++ +F+ + + ++ M G+L + ++ +G+ E A + +
Sbjct: 143 ELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMV 202
Query: 435 ALAIQYMHELEIAHRDIKCENVLL---TANQNVKLSDFGFARMCVDKKLNEIRSETFCGS 491
++Y+H L I HRD+K EN+L + + ++DFG A KK ++ +T CG+
Sbjct: 203 LDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLA--SARKKGDDCLMKTTCGT 260
Query: 492 LSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSR 551
Y APE+L PY D+W+LG++ Y++L+ MPFED + +L++ + + +
Sbjct: 261 PEYIAPEVLVRKPY-TNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGE 319
Query: 552 YIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
++S+ K I +L + R+ + W+
Sbjct: 320 PWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPWV 355
>AB040910-1|BAA96001.1| 870|Homo sapiens KIAA1477 protein protein.
Length = 870
Score = 140 bits (340), Expect = 1e-32
Identities = 84/265 (31%), Positives = 141/265 (53%), Gaps = 35/265 (13%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L K +G+G +AKV L + +A KII+ + + K RE+ ++ L
Sbjct: 172 YRLQKTIGKGNFAKVKLARHVLTGRE----VAVKIIDKTQLNPTSLQKLF-REVRIMKIL 226
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP++ G++ Y++ +G + E +AR RQ+ +QY H
Sbjct: 227 NHPNI----------------------GEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 264
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
+ I HRD+K EN+LL + N+K++DFGFS + +T+CGS YAAPE+ +G
Sbjct: 265 QKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKL----DTFCGSPPYAAPELFQG 320
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
K Y D+WSLGV+L+ +++ S+PFD +++L E+ + KY R+ +S +C+
Sbjct: 321 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY----RIPFYMSTDCEN 376
Query: 259 VVKHLLEPDPGLRHSATNVLDSEWI 283
++K LL +P R S ++ W+
Sbjct: 377 LLKKLLVLNPIKRGSLEQIMKDRWM 401
Score = 126 bits (305), Expect = 2e-28
Identities = 78/269 (28%), Positives = 144/269 (53%), Gaps = 19/269 (7%)
Query: 328 PTRESAFRVYLAEYRNA--SKNDKLSILACKVIDTSTAPRDFVKKFLPREI----EMLIK 381
PT+ S+ R + RN+ S D+ + + + +F K L R + E+ +K
Sbjct: 143 PTKSSS-RQNIPRCRNSITSATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVK 201
Query: 382 LSHPHLVHTHSIFQ--RRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQ 439
+ ++ S+ + R + + + G++ ++++ G ++E +AR RQ+ A+Q
Sbjct: 202 IIDKTQLNPTSLQKLFREVRIMKILNHPNIGEVFDYLVAHGRMKEKEARAKFRQIVSAVQ 261
Query: 440 YMHELEIAHRDIKCENVLLTANQNVKLSDFGFA-RMCVDKKLNEIRSETFCGSLSYTAPE 498
Y H+ I HRD+K EN+LL + N+K++DFGF+ V KL +TFCGS Y APE
Sbjct: 262 YCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKL-----DTFCGSPPYAAPE 316
Query: 499 ILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISD 558
+ QG Y DVWSLG+++Y +++ ++PF+ +++K+L + + K+R + +S
Sbjct: 317 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVL--RGKYRIPFY--MST 372
Query: 559 NCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+C+ L+ +L N R + I+ W+
Sbjct: 373 DCENLLKKLLVLNPIKRGSLEQIMKDRWM 401
>AK027493-1|BAB55152.1| 638|Homo sapiens protein ( Homo sapiens
cDNA FLJ14587 fis, clone NT2RM4001758, moderately
similar to PUTATIVE SERINE/THREONINE-PROTEIN KINASE EMK
(EC 2.7.1.-). ).
Length = 638
Score = 140 bits (338), Expect = 2e-32
Identities = 68/185 (36%), Positives = 111/185 (60%), Gaps = 10/185 (5%)
Query: 100 MRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLHELEIAHRDIKCENVLLTANFN 159
M Y G++ Y++ +G + E +AR RQ+ +QY H+ I HRD+K EN+LL + N
Sbjct: 1 MEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMN 60
Query: 160 VKLSDFGFS-RFCVESDNQPVLSETYCGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVM 218
+K++DFGFS F V + +T+CGS YAAPE+ +GK Y D+WSLGV+L+ +
Sbjct: 61 IKIADFGFSNEFTVGNK-----LDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTL 115
Query: 219 LNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKTVVKHLLEPDPGLRHSATNVL 278
++ S+PFD +++L E+ + KY R+ +S +C+ ++K LL +P R S ++
Sbjct: 116 VSGSLPFDGQNLKELRERVLRGKY----RIPFYMSTDCENLLKKLLVLNPIKRGSLEQIM 171
Query: 279 DSEWI 283
W+
Sbjct: 172 KDRWM 176
Score = 129 bits (312), Expect = 3e-29
Identities = 64/185 (34%), Positives = 110/185 (59%), Gaps = 10/185 (5%)
Query: 404 MRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQN 463
M Y G++ ++++ G ++E +AR RQ+ A+QY H+ I HRD+K EN+LL + N
Sbjct: 1 MEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMN 60
Query: 464 VKLSDFGFA-RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVM 522
+K++DFGF+ V KL +TFCGS Y APE+ QG Y DVWSLG+++Y +
Sbjct: 61 IKIADFGFSNEFTVGNKL-----DTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTL 115
Query: 523 LNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIV 582
++ ++PF+ +++K+L + + K+R + +S +C+ L+ +L N R + I+
Sbjct: 116 VSGSLPFDGQNLKELRERVL--RGKYRIPFY--MSTDCENLLKKLLVLNPIKRGSLEQIM 171
Query: 583 NSEWI 587
W+
Sbjct: 172 KDRWM 176
>AK074578-1|BAC11070.1| 426|Homo sapiens protein ( Homo sapiens
cDNA FLJ90097 fis, clone HEMBA1005929, weakly similar to
H.sapiens mRNA for serine/threonine protein kinase EMK.
).
Length = 426
Score = 139 bits (337), Expect = 2e-32
Identities = 67/185 (36%), Positives = 111/185 (60%), Gaps = 10/185 (5%)
Query: 100 MRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLHELEIAHRDIKCENVLLTANFN 159
M Y G++ Y++ +G + E +AR RQ+ + Y H+ I HRD+K EN+LL A N
Sbjct: 1 MEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEAN 60
Query: 160 VKLSDFGFS-RFCVESDNQPVLSETYCGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVM 218
+K++DFGFS F + S +T+CGS YAAPE+ +GK Y D+WSLGV+L+ +
Sbjct: 61 IKIADFGFSNEFTLGSK-----LDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTL 115
Query: 219 LNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKTVVKHLLEPDPGLRHSATNVL 278
++ S+PFD +++L E+ + KY RV +S +C+++++ L +P R + ++
Sbjct: 116 VSGSLPFDGHNLKELRERVLRGKY----RVPFYMSTDCESILRRFLVLNPAKRCTLEQIM 171
Query: 279 DSEWI 283
+WI
Sbjct: 172 KDKWI 176
Score = 128 bits (310), Expect = 5e-29
Identities = 62/185 (33%), Positives = 108/185 (58%), Gaps = 10/185 (5%)
Query: 404 MRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQN 463
M Y G++ ++++ G ++E +AR RQ+ A+ Y H+ I HRD+K EN+LL A N
Sbjct: 1 MEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEAN 60
Query: 464 VKLSDFGFA-RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVM 522
+K++DFGF+ + KL +TFCGS Y APE+ QG Y D+WSLG+++Y +
Sbjct: 61 IKIADFGFSNEFTLGSKL-----DTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTL 115
Query: 523 LNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIV 582
++ ++PF+ ++K+L + + K+R + +S +C+ ++ L N R + I+
Sbjct: 116 VSGSLPFDGHNLKELRERVL--RGKYRVPFY--MSTDCESILRRFLVLNPAKRCTLEQIM 171
Query: 583 NSEWI 587
+WI
Sbjct: 172 KDKWI 176
>BC035745-1|AAH35745.1| 385|Homo sapiens
calcium/calmodulin-dependent protein kinase ID protein.
Length = 385
Score = 139 bits (336), Expect = 3e-32
Identities = 89/278 (32%), Positives = 142/278 (51%), Gaps = 14/278 (5%)
Query: 15 LTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDV 74
+ K ++ + +G GA+++V L E E + A K I KA K + EI V
Sbjct: 19 IKKIFEFKETLGTGAFSEVVLAE----EKATGKLFAVKCIPK-KALKG-KESSIENEIAV 72
Query: 75 LVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGL 134
L ++ H +++ + I++ Y+ M+ G+L I++ G +E A RQ+ +
Sbjct: 73 LRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAV 132
Query: 135 QYLHELEIAHRDIKCENVLLTA---NFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYA 191
YLH + I HRD+K EN+L + + +SDFG S+ + D V+S T CG+ Y
Sbjct: 133 YYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGD---VMS-TACGTPGYV 188
Query: 192 APEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASI 251
APE+L KPY K D WS+GV+ +++L PF D KL+EQ + +Y F S
Sbjct: 189 APEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDD 247
Query: 252 LSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRL 289
+S K +++L+E DP R++ WIA D+ L
Sbjct: 248 ISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTAL 285
Score = 126 bits (305), Expect = 2e-28
Identities = 79/283 (27%), Positives = 139/283 (49%), Gaps = 11/283 (3%)
Query: 372 LPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWT 431
+ EI +L K+ H ++V I++ ++ M+ + G+L + ++++G E A
Sbjct: 66 IENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLI 125
Query: 432 RQLALAIQYMHELEIAHRDIKCENVLLTA---NQNVKLSDFGFARMCVDKKLNEIRSETF 488
RQ+ A+ Y+H + I HRD+K EN+L + + +SDFG ++M + ++ S T
Sbjct: 126 RQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKM---EGKGDVMS-TA 181
Query: 489 CGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKF 548
CG+ Y APE+L PY K D WS+G++ Y++L PF D++ +L + + ++F
Sbjct: 182 CGTPGYVAPEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF 240
Query: 549 RSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRLLEWTPQETLAYKKAR 608
S Y D ISD+ K I ++E + R WIA D+ L + + A +
Sbjct: 241 DSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKN 300
Query: 609 EEKNKLHKTVETVELPGSSKTEHKVCLPDSLVENNLDGAASTS 651
K+K + + + H L SL +N ++S S
Sbjct: 301 FAKSKWRQAFNATAVVRHMRKLH---LGSSLDSSNASVSSSLS 340
>AL731559-2|CAI14675.1| 385|Homo sapiens
calcium/calmodulin-dependent protein kinase ID protein.
Length = 385
Score = 139 bits (336), Expect = 3e-32
Identities = 89/278 (32%), Positives = 142/278 (51%), Gaps = 14/278 (5%)
Query: 15 LTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDV 74
+ K ++ + +G GA+++V L E E + A K I KA K + EI V
Sbjct: 19 IKKIFEFKETLGTGAFSEVVLAE----EKATGKLFAVKCIPK-KALKG-KESSIENEIAV 72
Query: 75 LVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGL 134
L ++ H +++ + I++ Y+ M+ G+L I++ G +E A RQ+ +
Sbjct: 73 LRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAV 132
Query: 135 QYLHELEIAHRDIKCENVLLTA---NFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYA 191
YLH + I HRD+K EN+L + + +SDFG S+ + D V+S T CG+ Y
Sbjct: 133 YYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGD---VMS-TACGTPGYV 188
Query: 192 APEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASI 251
APE+L KPY K D WS+GV+ +++L PF D KL+EQ + +Y F S
Sbjct: 189 APEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDD 247
Query: 252 LSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRL 289
+S K +++L+E DP R++ WIA D+ L
Sbjct: 248 ISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTAL 285
Score = 126 bits (305), Expect = 2e-28
Identities = 79/283 (27%), Positives = 139/283 (49%), Gaps = 11/283 (3%)
Query: 372 LPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWT 431
+ EI +L K+ H ++V I++ ++ M+ + G+L + ++++G E A
Sbjct: 66 IENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLI 125
Query: 432 RQLALAIQYMHELEIAHRDIKCENVLLTA---NQNVKLSDFGFARMCVDKKLNEIRSETF 488
RQ+ A+ Y+H + I HRD+K EN+L + + +SDFG ++M + ++ S T
Sbjct: 126 RQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKM---EGKGDVMS-TA 181
Query: 489 CGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKF 548
CG+ Y APE+L PY K D WS+G++ Y++L PF D++ +L + + ++F
Sbjct: 182 CGTPGYVAPEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF 240
Query: 549 RSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRLLEWTPQETLAYKKAR 608
S Y D ISD+ K I ++E + R WIA D+ L + + A +
Sbjct: 241 DSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKN 300
Query: 609 EEKNKLHKTVETVELPGSSKTEHKVCLPDSLVENNLDGAASTS 651
K+K + + + H L SL +N ++S S
Sbjct: 301 FAKSKWRQAFNATAVVRHMRKLH---LGSSLDSSNASVSSSLS 340
>AL731559-1|CAI14674.1| 357|Homo sapiens
calcium/calmodulin-dependent protein kinase ID protein.
Length = 357
Score = 139 bits (336), Expect = 3e-32
Identities = 89/278 (32%), Positives = 142/278 (51%), Gaps = 14/278 (5%)
Query: 15 LTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDV 74
+ K ++ + +G GA+++V L E E + A K I KA K + EI V
Sbjct: 19 IKKIFEFKETLGTGAFSEVVLAE----EKATGKLFAVKCIPK-KALKG-KESSIENEIAV 72
Query: 75 LVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGL 134
L ++ H +++ + I++ Y+ M+ G+L I++ G +E A RQ+ +
Sbjct: 73 LRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAV 132
Query: 135 QYLHELEIAHRDIKCENVLLTA---NFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYA 191
YLH + I HRD+K EN+L + + +SDFG S+ + D V+S T CG+ Y
Sbjct: 133 YYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGD---VMS-TACGTPGYV 188
Query: 192 APEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASI 251
APE+L KPY K D WS+GV+ +++L PF D KL+EQ + +Y F S
Sbjct: 189 APEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDD 247
Query: 252 LSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRL 289
+S K +++L+E DP R++ WIA D+ L
Sbjct: 248 ISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTAL 285
Score = 126 bits (305), Expect = 2e-28
Identities = 79/283 (27%), Positives = 139/283 (49%), Gaps = 11/283 (3%)
Query: 372 LPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWT 431
+ EI +L K+ H ++V I++ ++ M+ + G+L + ++++G E A
Sbjct: 66 IENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLI 125
Query: 432 RQLALAIQYMHELEIAHRDIKCENVLLTA---NQNVKLSDFGFARMCVDKKLNEIRSETF 488
RQ+ A+ Y+H + I HRD+K EN+L + + +SDFG ++M + ++ S T
Sbjct: 126 RQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKM---EGKGDVMS-TA 181
Query: 489 CGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKF 548
CG+ Y APE+L PY K D WS+G++ Y++L PF D++ +L + + ++F
Sbjct: 182 CGTPGYVAPEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF 240
Query: 549 RSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRLLEWTPQETLAYKKAR 608
S Y D ISD+ K I ++E + R WIA D+ L + + A +
Sbjct: 241 DSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKN 300
Query: 609 EEKNKLHKTVETVELPGSSKTEHKVCLPDSLVENNLDGAASTS 651
K+K + + + H L SL +N ++S S
Sbjct: 301 FAKSKWRQAFNATAVVRHMRKLH---LGSSLDSSNASVSSSLS 340
>AL512783-2|CAH74036.1| 385|Homo sapiens
calcium/calmodulin-dependent protein kinase ID protein.
Length = 385
Score = 139 bits (336), Expect = 3e-32
Identities = 89/278 (32%), Positives = 142/278 (51%), Gaps = 14/278 (5%)
Query: 15 LTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDV 74
+ K ++ + +G GA+++V L E E + A K I KA K + EI V
Sbjct: 19 IKKIFEFKETLGTGAFSEVVLAE----EKATGKLFAVKCIPK-KALKG-KESSIENEIAV 72
Query: 75 LVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGL 134
L ++ H +++ + I++ Y+ M+ G+L I++ G +E A RQ+ +
Sbjct: 73 LRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAV 132
Query: 135 QYLHELEIAHRDIKCENVLLTA---NFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYA 191
YLH + I HRD+K EN+L + + +SDFG S+ + D V+S T CG+ Y
Sbjct: 133 YYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGD---VMS-TACGTPGYV 188
Query: 192 APEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASI 251
APE+L KPY K D WS+GV+ +++L PF D KL+EQ + +Y F S
Sbjct: 189 APEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDD 247
Query: 252 LSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRL 289
+S K +++L+E DP R++ WIA D+ L
Sbjct: 248 ISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTAL 285
Score = 126 bits (305), Expect = 2e-28
Identities = 79/283 (27%), Positives = 139/283 (49%), Gaps = 11/283 (3%)
Query: 372 LPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWT 431
+ EI +L K+ H ++V I++ ++ M+ + G+L + ++++G E A
Sbjct: 66 IENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLI 125
Query: 432 RQLALAIQYMHELEIAHRDIKCENVLLTA---NQNVKLSDFGFARMCVDKKLNEIRSETF 488
RQ+ A+ Y+H + I HRD+K EN+L + + +SDFG ++M + ++ S T
Sbjct: 126 RQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKM---EGKGDVMS-TA 181
Query: 489 CGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKF 548
CG+ Y APE+L PY K D WS+G++ Y++L PF D++ +L + + ++F
Sbjct: 182 CGTPGYVAPEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF 240
Query: 549 RSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRLLEWTPQETLAYKKAR 608
S Y D ISD+ K I ++E + R WIA D+ L + + A +
Sbjct: 241 DSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKN 300
Query: 609 EEKNKLHKTVETVELPGSSKTEHKVCLPDSLVENNLDGAASTS 651
K+K + + + H L SL +N ++S S
Sbjct: 301 FAKSKWRQAFNATAVVRHMRKLH---LGSSLDSSNASVSSSLS 340
>AL512783-1|CAH74035.1| 357|Homo sapiens
calcium/calmodulin-dependent protein kinase ID protein.
Length = 357
Score = 139 bits (336), Expect = 3e-32
Identities = 89/278 (32%), Positives = 142/278 (51%), Gaps = 14/278 (5%)
Query: 15 LTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDV 74
+ K ++ + +G GA+++V L E E + A K I KA K + EI V
Sbjct: 19 IKKIFEFKETLGTGAFSEVVLAE----EKATGKLFAVKCIPK-KALKG-KESSIENEIAV 72
Query: 75 LVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGL 134
L ++ H +++ + I++ Y+ M+ G+L I++ G +E A RQ+ +
Sbjct: 73 LRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAV 132
Query: 135 QYLHELEIAHRDIKCENVLLTA---NFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYA 191
YLH + I HRD+K EN+L + + +SDFG S+ + D V+S T CG+ Y
Sbjct: 133 YYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGD---VMS-TACGTPGYV 188
Query: 192 APEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASI 251
APE+L KPY K D WS+GV+ +++L PF D KL+EQ + +Y F S
Sbjct: 189 APEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDD 247
Query: 252 LSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRL 289
+S K +++L+E DP R++ WIA D+ L
Sbjct: 248 ISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTAL 285
Score = 126 bits (305), Expect = 2e-28
Identities = 79/283 (27%), Positives = 139/283 (49%), Gaps = 11/283 (3%)
Query: 372 LPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWT 431
+ EI +L K+ H ++V I++ ++ M+ + G+L + ++++G E A
Sbjct: 66 IENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLI 125
Query: 432 RQLALAIQYMHELEIAHRDIKCENVLLTA---NQNVKLSDFGFARMCVDKKLNEIRSETF 488
RQ+ A+ Y+H + I HRD+K EN+L + + +SDFG ++M + ++ S T
Sbjct: 126 RQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKM---EGKGDVMS-TA 181
Query: 489 CGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKF 548
CG+ Y APE+L PY K D WS+G++ Y++L PF D++ +L + + ++F
Sbjct: 182 CGTPGYVAPEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF 240
Query: 549 RSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRLLEWTPQETLAYKKAR 608
S Y D ISD+ K I ++E + R WIA D+ L + + A +
Sbjct: 241 DSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKN 300
Query: 609 EEKNKLHKTVETVELPGSSKTEHKVCLPDSLVENNLDGAASTS 651
K+K + + + H L SL +N ++S S
Sbjct: 301 FAKSKWRQAFNATAVVRHMRKLH---LGSSLDSSNASVSSSLS 340
>AL512284-2|CAH71694.1| 385|Homo sapiens
calcium/calmodulin-dependent protein kinase ID protein.
Length = 385
Score = 139 bits (336), Expect = 3e-32
Identities = 89/278 (32%), Positives = 142/278 (51%), Gaps = 14/278 (5%)
Query: 15 LTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDV 74
+ K ++ + +G GA+++V L E E + A K I KA K + EI V
Sbjct: 19 IKKIFEFKETLGTGAFSEVVLAE----EKATGKLFAVKCIPK-KALKG-KESSIENEIAV 72
Query: 75 LVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGL 134
L ++ H +++ + I++ Y+ M+ G+L I++ G +E A RQ+ +
Sbjct: 73 LRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAV 132
Query: 135 QYLHELEIAHRDIKCENVLLTA---NFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYA 191
YLH + I HRD+K EN+L + + +SDFG S+ + D V+S T CG+ Y
Sbjct: 133 YYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGD---VMS-TACGTPGYV 188
Query: 192 APEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASI 251
APE+L KPY K D WS+GV+ +++L PF D KL+EQ + +Y F S
Sbjct: 189 APEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDD 247
Query: 252 LSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRL 289
+S K +++L+E DP R++ WIA D+ L
Sbjct: 248 ISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTAL 285
Score = 126 bits (305), Expect = 2e-28
Identities = 79/283 (27%), Positives = 139/283 (49%), Gaps = 11/283 (3%)
Query: 372 LPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWT 431
+ EI +L K+ H ++V I++ ++ M+ + G+L + ++++G E A
Sbjct: 66 IENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLI 125
Query: 432 RQLALAIQYMHELEIAHRDIKCENVLLTA---NQNVKLSDFGFARMCVDKKLNEIRSETF 488
RQ+ A+ Y+H + I HRD+K EN+L + + +SDFG ++M + ++ S T
Sbjct: 126 RQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKM---EGKGDVMS-TA 181
Query: 489 CGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKF 548
CG+ Y APE+L PY K D WS+G++ Y++L PF D++ +L + + ++F
Sbjct: 182 CGTPGYVAPEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF 240
Query: 549 RSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRLLEWTPQETLAYKKAR 608
S Y D ISD+ K I ++E + R WIA D+ L + + A +
Sbjct: 241 DSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKN 300
Query: 609 EEKNKLHKTVETVELPGSSKTEHKVCLPDSLVENNLDGAASTS 651
K+K + + + H L SL +N ++S S
Sbjct: 301 FAKSKWRQAFNATAVVRHMRKLH---LGSSLDSSNASVSSSLS 340
>AL512284-1|CAH71693.1| 357|Homo sapiens
calcium/calmodulin-dependent protein kinase ID protein.
Length = 357
Score = 139 bits (336), Expect = 3e-32
Identities = 89/278 (32%), Positives = 142/278 (51%), Gaps = 14/278 (5%)
Query: 15 LTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDV 74
+ K ++ + +G GA+++V L E E + A K I KA K + EI V
Sbjct: 19 IKKIFEFKETLGTGAFSEVVLAE----EKATGKLFAVKCIPK-KALKG-KESSIENEIAV 72
Query: 75 LVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGL 134
L ++ H +++ + I++ Y+ M+ G+L I++ G +E A RQ+ +
Sbjct: 73 LRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAV 132
Query: 135 QYLHELEIAHRDIKCENVLLTA---NFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYA 191
YLH + I HRD+K EN+L + + +SDFG S+ + D V+S T CG+ Y
Sbjct: 133 YYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGD---VMS-TACGTPGYV 188
Query: 192 APEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASI 251
APE+L KPY K D WS+GV+ +++L PF D KL+EQ + +Y F S
Sbjct: 189 APEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDD 247
Query: 252 LSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRL 289
+S K +++L+E DP R++ WIA D+ L
Sbjct: 248 ISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTAL 285
Score = 126 bits (305), Expect = 2e-28
Identities = 79/283 (27%), Positives = 139/283 (49%), Gaps = 11/283 (3%)
Query: 372 LPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWT 431
+ EI +L K+ H ++V I++ ++ M+ + G+L + ++++G E A
Sbjct: 66 IENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLI 125
Query: 432 RQLALAIQYMHELEIAHRDIKCENVLLTA---NQNVKLSDFGFARMCVDKKLNEIRSETF 488
RQ+ A+ Y+H + I HRD+K EN+L + + +SDFG ++M + ++ S T
Sbjct: 126 RQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKM---EGKGDVMS-TA 181
Query: 489 CGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKF 548
CG+ Y APE+L PY K D WS+G++ Y++L PF D++ +L + + ++F
Sbjct: 182 CGTPGYVAPEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF 240
Query: 549 RSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRLLEWTPQETLAYKKAR 608
S Y D ISD+ K I ++E + R WIA D+ L + + A +
Sbjct: 241 DSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKN 300
Query: 609 EEKNKLHKTVETVELPGSSKTEHKVCLPDSLVENNLDGAASTS 651
K+K + + + H L SL +N ++S S
Sbjct: 301 FAKSKWRQAFNATAVVRHMRKLH---LGSSLDSSNASVSSSLS 340
>AL391314-2|CAI14410.1| 385|Homo sapiens
calcium/calmodulin-dependent protein kinase ID protein.
Length = 385
Score = 139 bits (336), Expect = 3e-32
Identities = 89/278 (32%), Positives = 142/278 (51%), Gaps = 14/278 (5%)
Query: 15 LTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDV 74
+ K ++ + +G GA+++V L E E + A K I KA K + EI V
Sbjct: 19 IKKIFEFKETLGTGAFSEVVLAE----EKATGKLFAVKCIPK-KALKG-KESSIENEIAV 72
Query: 75 LVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGL 134
L ++ H +++ + I++ Y+ M+ G+L I++ G +E A RQ+ +
Sbjct: 73 LRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAV 132
Query: 135 QYLHELEIAHRDIKCENVLLTA---NFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYA 191
YLH + I HRD+K EN+L + + +SDFG S+ + D V+S T CG+ Y
Sbjct: 133 YYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGD---VMS-TACGTPGYV 188
Query: 192 APEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASI 251
APE+L KPY K D WS+GV+ +++L PF D KL+EQ + +Y F S
Sbjct: 189 APEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDD 247
Query: 252 LSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRL 289
+S K +++L+E DP R++ WIA D+ L
Sbjct: 248 ISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTAL 285
Score = 126 bits (305), Expect = 2e-28
Identities = 79/283 (27%), Positives = 139/283 (49%), Gaps = 11/283 (3%)
Query: 372 LPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWT 431
+ EI +L K+ H ++V I++ ++ M+ + G+L + ++++G E A
Sbjct: 66 IENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLI 125
Query: 432 RQLALAIQYMHELEIAHRDIKCENVLLTA---NQNVKLSDFGFARMCVDKKLNEIRSETF 488
RQ+ A+ Y+H + I HRD+K EN+L + + +SDFG ++M + ++ S T
Sbjct: 126 RQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKM---EGKGDVMS-TA 181
Query: 489 CGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKF 548
CG+ Y APE+L PY K D WS+G++ Y++L PF D++ +L + + ++F
Sbjct: 182 CGTPGYVAPEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF 240
Query: 549 RSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRLLEWTPQETLAYKKAR 608
S Y D ISD+ K I ++E + R WIA D+ L + + A +
Sbjct: 241 DSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKN 300
Query: 609 EEKNKLHKTVETVELPGSSKTEHKVCLPDSLVENNLDGAASTS 651
K+K + + + H L SL +N ++S S
Sbjct: 301 FAKSKWRQAFNATAVVRHMRKLH---LGSSLDSSNASVSSSLS 340
>AL391314-1|CAI14409.1| 357|Homo sapiens
calcium/calmodulin-dependent protein kinase ID protein.
Length = 357
Score = 139 bits (336), Expect = 3e-32
Identities = 89/278 (32%), Positives = 142/278 (51%), Gaps = 14/278 (5%)
Query: 15 LTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDV 74
+ K ++ + +G GA+++V L E E + A K I KA K + EI V
Sbjct: 19 IKKIFEFKETLGTGAFSEVVLAE----EKATGKLFAVKCIPK-KALKG-KESSIENEIAV 72
Query: 75 LVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGL 134
L ++ H +++ + I++ Y+ M+ G+L I++ G +E A RQ+ +
Sbjct: 73 LRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAV 132
Query: 135 QYLHELEIAHRDIKCENVLLTA---NFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYA 191
YLH + I HRD+K EN+L + + +SDFG S+ + D V+S T CG+ Y
Sbjct: 133 YYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGD---VMS-TACGTPGYV 188
Query: 192 APEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASI 251
APE+L KPY K D WS+GV+ +++L PF D KL+EQ + +Y F S
Sbjct: 189 APEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDD 247
Query: 252 LSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRL 289
+S K +++L+E DP R++ WIA D+ L
Sbjct: 248 ISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTAL 285
Score = 126 bits (305), Expect = 2e-28
Identities = 79/283 (27%), Positives = 139/283 (49%), Gaps = 11/283 (3%)
Query: 372 LPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWT 431
+ EI +L K+ H ++V I++ ++ M+ + G+L + ++++G E A
Sbjct: 66 IENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLI 125
Query: 432 RQLALAIQYMHELEIAHRDIKCENVLLTA---NQNVKLSDFGFARMCVDKKLNEIRSETF 488
RQ+ A+ Y+H + I HRD+K EN+L + + +SDFG ++M + ++ S T
Sbjct: 126 RQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKM---EGKGDVMS-TA 181
Query: 489 CGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKF 548
CG+ Y APE+L PY K D WS+G++ Y++L PF D++ +L + + ++F
Sbjct: 182 CGTPGYVAPEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF 240
Query: 549 RSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRLLEWTPQETLAYKKAR 608
S Y D ISD+ K I ++E + R WIA D+ L + + A +
Sbjct: 241 DSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKN 300
Query: 609 EEKNKLHKTVETVELPGSSKTEHKVCLPDSLVENNLDGAASTS 651
K+K + + + H L SL +N ++S S
Sbjct: 301 FAKSKWRQAFNATAVVRHMRKLH---LGSSLDSSNASVSSSLS 340
>AJ006701-1|CAA07196.1| 603|Homo sapiens putative serine/threonine
protein kinase protein.
Length = 603
Score = 139 bits (336), Expect = 3e-32
Identities = 66/205 (32%), Positives = 115/205 (56%), Gaps = 8/205 (3%)
Query: 78 LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYL 137
+ HPH++ +H +++ K Y+ + + G+L Y++K G ++ +AR + RQ+ L +
Sbjct: 2 IEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFC 61
Query: 138 HELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILR 197
H I HRD+K EN+LL N++++DFG + V L ET CGS YA PE++R
Sbjct: 62 HSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDS----LLETSCGSPHYACPEVIR 117
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECK 257
G+ Y + D+WS GV+LF +L ++PFDD +R+L E K R + + +C+
Sbjct: 118 GEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLE----KVKRGVFHMPHFIPPDCQ 173
Query: 258 TVVKHLLEPDPGLRHSATNVLDSEW 282
++++ + E D R + ++ W
Sbjct: 174 SLLRGMSEVDAARRLTLEHIQKHIW 198
Score = 128 bits (308), Expect = 8e-29
Identities = 62/205 (30%), Positives = 115/205 (56%), Gaps = 8/205 (3%)
Query: 382 LSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYM 441
+ HPH++ H +++ + ++ + ++ G+L ++++++G + +AR + RQ+ A+ +
Sbjct: 2 IEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFC 61
Query: 442 HELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQ 501
H I HRD+K EN+LL N++++DFG A + V L ET CGS Y PE+++
Sbjct: 62 HSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSL----LETSCGSPHYACPEVIR 117
Query: 502 GTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCK 561
G Y + DVWS G++++ +L A+PF+D +++QL + K F + I +C+
Sbjct: 118 GEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKV--KRGVFHMPHF--IPPDCQ 173
Query: 562 RLIGLMLEPNHQNRLKIYDIVNSEW 586
L+ M E + RL + I W
Sbjct: 174 SLLRGMSEVDAARRLTLEHIQKHIW 198
>AF286366-1|AAG00534.1| 357|Homo sapiens CamKI-like protein kinase
protein.
Length = 357
Score = 139 bits (336), Expect = 3e-32
Identities = 89/278 (32%), Positives = 142/278 (51%), Gaps = 14/278 (5%)
Query: 15 LTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDV 74
+ K ++ + +G GA+++V L E E + A K I KA K + EI V
Sbjct: 19 IKKIFEFKETLGTGAFSEVVLAE----EKATGKLFAVKCIPK-KALKG-KESSIENEIAV 72
Query: 75 LVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGL 134
L ++ H +++ + I++ Y+ M+ G+L I++ G +E A RQ+ +
Sbjct: 73 LRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAV 132
Query: 135 QYLHELEIAHRDIKCENVLLTA---NFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYA 191
YLH + I HRD+K EN+L + + +SDFG S+ + D V+S T CG+ Y
Sbjct: 133 YYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGD---VMS-TACGTPGYV 188
Query: 192 APEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASI 251
APE+L KPY K D WS+GV+ +++L PF D KL+EQ + +Y F S
Sbjct: 189 APEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDD 247
Query: 252 LSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRL 289
+S K +++L+E DP R++ WIA D+ L
Sbjct: 248 ISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTAL 285
Score = 126 bits (305), Expect = 2e-28
Identities = 79/283 (27%), Positives = 139/283 (49%), Gaps = 11/283 (3%)
Query: 372 LPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWT 431
+ EI +L K+ H ++V I++ ++ M+ + G+L + ++++G E A
Sbjct: 66 IENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLI 125
Query: 432 RQLALAIQYMHELEIAHRDIKCENVLLTA---NQNVKLSDFGFARMCVDKKLNEIRSETF 488
RQ+ A+ Y+H + I HRD+K EN+L + + +SDFG ++M + ++ S T
Sbjct: 126 RQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKM---EGKGDVMS-TA 181
Query: 489 CGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKF 548
CG+ Y APE+L PY K D WS+G++ Y++L PF D++ +L + + ++F
Sbjct: 182 CGTPGYVAPEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF 240
Query: 549 RSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRLLEWTPQETLAYKKAR 608
S Y D ISD+ K I ++E + R WIA D+ L + + A +
Sbjct: 241 DSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKN 300
Query: 609 EEKNKLHKTVETVELPGSSKTEHKVCLPDSLVENNLDGAASTS 651
K+K + + + H L SL +N ++S S
Sbjct: 301 FAKSKWRQAFNATAVVRHMRKLH---LGSSLDSSNASVSSSLS 340
>AB081726-1|BAC19846.1| 385|Homo sapiens CaM-kinase I delta
protein.
Length = 385
Score = 139 bits (336), Expect = 3e-32
Identities = 89/278 (32%), Positives = 142/278 (51%), Gaps = 14/278 (5%)
Query: 15 LTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDV 74
+ K ++ + +G GA+++V L E E + A K I KA K + EI V
Sbjct: 19 IKKIFEFKETLGTGAFSEVVLAE----EKATGKLFAVKCIPK-KALKG-KESSIENEIAV 72
Query: 75 LVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGL 134
L ++ H +++ + I++ Y+ M+ G+L I++ G +E A RQ+ +
Sbjct: 73 LRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAV 132
Query: 135 QYLHELEIAHRDIKCENVLLTA---NFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYA 191
YLH + I HRD+K EN+L + + +SDFG S+ + D V+S T CG+ Y
Sbjct: 133 YYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGD---VMS-TACGTPGYV 188
Query: 192 APEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASI 251
APE+L KPY K D WS+GV+ +++L PF D KL+EQ + +Y F S
Sbjct: 189 APEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDD 247
Query: 252 LSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRL 289
+S K +++L+E DP R++ WIA D+ L
Sbjct: 248 ISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTAL 285
Score = 126 bits (305), Expect = 2e-28
Identities = 79/283 (27%), Positives = 139/283 (49%), Gaps = 11/283 (3%)
Query: 372 LPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWT 431
+ EI +L K+ H ++V I++ ++ M+ + G+L + ++++G E A
Sbjct: 66 IENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLI 125
Query: 432 RQLALAIQYMHELEIAHRDIKCENVLLTA---NQNVKLSDFGFARMCVDKKLNEIRSETF 488
RQ+ A+ Y+H + I HRD+K EN+L + + +SDFG ++M + ++ S T
Sbjct: 126 RQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKM---EGKGDVMS-TA 181
Query: 489 CGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKF 548
CG+ Y APE+L PY K D WS+G++ Y++L PF D++ +L + + ++F
Sbjct: 182 CGTPGYVAPEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF 240
Query: 549 RSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRLLEWTPQETLAYKKAR 608
S Y D ISD+ K I ++E + R WIA D+ L + + A +
Sbjct: 241 DSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKN 300
Query: 609 EEKNKLHKTVETVELPGSSKTEHKVCLPDSLVENNLDGAASTS 651
K+K + + + H L SL +N ++S S
Sbjct: 301 FAKSKWRQAFNATAVVRHMRKLH---LGSSLDSSNASVSSSLS 340
>D43636-1|BAA07744.2| 766|Homo sapiens KIAA0096 protein.
Length = 766
Score = 137 bits (331), Expect = 1e-31
Identities = 88/292 (30%), Positives = 147/292 (50%), Gaps = 18/292 (6%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y L K +G G +A V L + + +A K+I+ K L +E+ + +
Sbjct: 17 YDLDKTLGRGHFAVVKLARHVFTGEK----VAVKVIDKTKLDT-LATGHLFQEVRCMKLV 71
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNG-CVSENQARVWTRQLALGLQYL 137
HP+++ ++ + +TK Y+ + + GD+ YI+K+ ++E+ A+ + Q+ + Y
Sbjct: 72 QHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYC 131
Query: 138 HELEIAHRDIKCENVLLTANFN-VKLSDFGFSRFCVESDNQPVLS-ETYCGSMSYAAPEI 195
H+L + HRD+K ENV+ VKL+DFGFS + QP T CGS++Y+APEI
Sbjct: 132 HKLHVVHRDLKPENVVFFEKQGLVKLTDFGFS-----NKFQPGKKLTTSCGSLAYSAPEI 186
Query: 196 LRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLE 255
L G Y D+WSLGV+LF+++ PF + + M KY V S +S E
Sbjct: 187 LLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKY----TVPSHVSKE 242
Query: 256 CKTVVKHLLEPDPGLRHSATNVLDSEWI-AMDSRLTTLNAVEAAALKRAKED 306
CK ++ +L+ DP R S + + W+ +D T + + K E+
Sbjct: 243 CKDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYKNLSEE 294
Score = 124 bits (299), Expect = 1e-27
Identities = 78/264 (29%), Positives = 138/264 (52%), Gaps = 14/264 (5%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A KVID T L +E+ + + HP++V + + + K ++ + + GD+
Sbjct: 43 VAVKVID-KTKLDTLATGHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDM 101
Query: 413 LEFVLQRG-AVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQN-VKLSDFG 470
+++++ + ED A+ + Q+ AI Y H+L + HRD+K ENV+ Q VKL+DFG
Sbjct: 102 FDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFG 161
Query: 471 FA-RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPF 529
F+ + KKL T CGSL+Y+APEIL G Y D+WSLG+++++++ PF
Sbjct: 162 FSNKFQPGKKLT-----TSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPF 216
Query: 530 EDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI-A 588
++ + + ++ + S +S CK LI ML+ + + R + +I N W+
Sbjct: 217 QEANDSETLTMIMDCKYTVPSH----VSKECKDLITRMLQRDPKRRASLEEIENHPWLQG 272
Query: 589 MDSRLLEWTPQETLAYKKAREEKN 612
+D ++YK EE++
Sbjct: 273 VDPSPATKYNIPLVSYKNLSEEEH 296
>Y15056-1|CAA75341.1| 556|Homo sapiens PkB kinase protein.
Length = 556
Score = 136 bits (330), Expect = 2e-31
Identities = 72/237 (30%), Positives = 131/237 (55%), Gaps = 6/237 (2%)
Query: 8 PSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKF 67
P + + +K K +GEG+++ V L ++E + A KI+E K+ V +
Sbjct: 71 PPQPRKKRPEDFKFGKILGEGSFSTVVL----ARELATSREYAIKILEKRHIIKENKVPY 126
Query: 68 LPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWT 127
+ RE DV+ RL+HP + ++ FQ K Y + Y +NG+LL YI K G E R +T
Sbjct: 127 VTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYT 186
Query: 128 RQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGS 187
++ L+YLH I HRD+K EN+LL + +++++DFG ++ + +++ + ++ G+
Sbjct: 187 AEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAK-VLSPESKQARANSFVGT 245
Query: 188 MSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRF 244
Y +PE+L K C K +DLW+LG +++ ++ PF ++++ + +Y F
Sbjct: 246 AQYVSPELLTEKSAC-KSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDF 301
Score = 112 bits (270), Expect = 3e-24
Identities = 56/213 (26%), Positives = 116/213 (54%), Gaps = 2/213 (0%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLL 413
A K+++ ++ ++ RE +++ +L HP V + FQ K + + Y + G+LL
Sbjct: 109 AIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELL 168
Query: 414 EFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFAR 473
+++ + G+ E R +T ++ A++Y+H I HRD+K EN+LL + +++++DFG A+
Sbjct: 169 KYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAK 228
Query: 474 MCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKH 533
+ + + + R+ +F G+ Y +PE+L K +D+W+LG ++Y ++ PF +
Sbjct: 229 V-LSPESKQARANSFVGTAQYVSPELLTEKSAC-KSSDLWALGCIIYQLVAGLPPFRAGN 286
Query: 534 IKQLHQAQINKNWKFRSRYIDTISDNCKRLIGL 566
+ Q I + F ++ D ++L+ L
Sbjct: 287 EYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVL 319
>U08316-1|AAA81952.1| 740|Homo sapiens insulin-stimulated protein
kinase 1 protein.
Length = 740
Score = 136 bits (330), Expect = 2e-31
Identities = 76/256 (29%), Positives = 143/256 (55%), Gaps = 10/256 (3%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
++L K +G+G++ KV+L + S D+ + A K+++ A V+ E D+LV +
Sbjct: 68 FELLKVLGQGSFGKVFLVKKISGSDA-RQLYAMKVLKKATLKVRDRVR-TKMERDILVEV 125
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP ++ +H FQ + K Y+ + + GDL + + K +E + + +LAL L +LH
Sbjct: 126 NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLH 185
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
L I +RD+K EN+LL ++KL+DFG S+ ++ + + + ++CG++ Y APE++
Sbjct: 186 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKK---AYSFCGTVEYMAPEVVNR 242
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ + + D WS GV++F ML ++PF K ++ M + + + LS E ++
Sbjct: 243 RGH-TQSADWWSFGVLMFEMLTGTLPFQG----KDRKETMTMILKAKLGMPQFLSPEAQS 297
Query: 259 VVKHLLEPDPGLRHSA 274
+++ L + +P R A
Sbjct: 298 LLRMLFKRNPANRLGA 313
Score = 122 bits (294), Expect = 4e-27
Identities = 74/264 (28%), Positives = 142/264 (53%), Gaps = 13/264 (4%)
Query: 314 HKHPPKRQGDILEGPTRESAFRVYLAEYRNASKNDKLSILACKVIDTSTAP-RDFVKKFL 372
H+ Q ++L+ + S +V+L + S +D + A KV+ +T RD V+ +
Sbjct: 60 HEKADPSQFELLKVLGQGSFGKVFLV--KKISGSDARQLYAMKVLKKATLKVRDRVRTKM 117
Query: 373 PREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTR 432
R+I L++++HP +V H FQ K ++ + ++ GDL + + E+ + +
Sbjct: 118 ERDI--LVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA 175
Query: 433 QLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSL 492
+LALA+ ++H L I +RD+K EN+LL ++KL+DFG ++ +D +E ++ +FCG++
Sbjct: 176 ELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESID---HEKKAYSFCGTV 232
Query: 493 SYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRY 552
Y APE++ + + D WS G++++ ML +PF+ K K+ + K +
Sbjct: 233 EYMAPEVVNRRGH-TQSADWWSFGVLMFEMLTGTLPFQGKDRKE----TMTMILKAKLGM 287
Query: 553 IDTISDNCKRLIGLMLEPNHQNRL 576
+S + L+ ++ + N NRL
Sbjct: 288 PQFLSPEAQSLLRMLFKRNPANRL 311
Score = 99.1 bits (236), Expect = 4e-20
Identities = 82/280 (29%), Positives = 134/280 (47%), Gaps = 31/280 (11%)
Query: 16 TKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKST---LACKIIETAKAPKDFVVKFLPREI 72
T GY++ + +G G+Y+ K HK+T A KII+ +K EI
Sbjct: 419 TDGYEVKEDIGVGSYSVC-------KRCIHKATNMEFAVKIIDKSKRDPT-------EEI 464
Query: 73 DVLVRLN-HPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLA 131
++L+R HP++I + ++ Y+ + G+LL IL+ SE +A +
Sbjct: 465 EILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTIT 524
Query: 132 LGLQYLHELEIAHRDIKCENVLLTANF----NVKLSDFGFSRFCVESDNQPVLSETYCGS 187
++YLH + HRD+K N+L ++++ DFGF++ + ++N L T C +
Sbjct: 525 KTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAK-QLRAENG--LLMTPCYT 581
Query: 188 MSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPF----DDTRMRKLYEQQMGKKYR 243
++ APE+L+ + Y D+WSLGV+L+ ML PF DDT L G K+
Sbjct: 582 ANFVAPEVLKRQGY-DAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSG-KFS 639
Query: 244 FRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+ +S K +V +L DP R +A VL WI
Sbjct: 640 LSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 679
Score = 89.4 bits (212), Expect = 3e-17
Identities = 58/230 (25%), Positives = 112/230 (48%), Gaps = 12/230 (5%)
Query: 366 DFVKKFLPREIEMLIKLS-HPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQE 424
D K+ EIE+L++ HP+++ ++ ++ M+ G+LL+ +L++ E
Sbjct: 454 DKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSE 513
Query: 425 DQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTAN----QNVKLSDFGFARMCVDKKL 480
+A + ++Y+H + HRD+K N+L +++++ DFGFA+ +
Sbjct: 514 REASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQL--RAE 571
Query: 481 NEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPF---EDKHIKQL 537
N + T C + ++ APE+L+ Y D+WSLG+++Y ML PF D +++
Sbjct: 572 NGLLM-TPCYTANFVAPEVLKRQGY-DAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEI 629
Query: 538 HQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+ + Y +++SD K L+ ML + RL ++ WI
Sbjct: 630 LARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 679
>L07599-1|AAC82495.1| 580|Homo sapiens ribosomal protein S6 kinase
3 protein.
Length = 580
Score = 136 bits (330), Expect = 2e-31
Identities = 76/256 (29%), Positives = 143/256 (55%), Gaps = 10/256 (3%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
++L K +G+G++ KV+L + S D+ + A K+++ A V+ E D+LV +
Sbjct: 67 FELLKVLGQGSFGKVFLVKKISGSDA-RQLYAMKVLKKATLKVRDRVR-TKMERDILVEV 124
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP ++ +H FQ + K Y+ + + GDL + + K +E + + +LAL L +LH
Sbjct: 125 NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLH 184
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
L I +RD+K EN+LL ++KL+DFG S+ ++ + + + ++CG++ Y APE++
Sbjct: 185 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKK---AYSFCGTVEYMAPEVVNR 241
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ + + D WS GV++F ML ++PF K ++ M + + + LS E ++
Sbjct: 242 RGH-TQSADWWSFGVLMFEMLTGTLPFQG----KDRKETMTMILKAKLGMPQFLSPEAQS 296
Query: 259 VVKHLLEPDPGLRHSA 274
+++ L + +P R A
Sbjct: 297 LLRMLFKRNPANRLGA 312
Score = 122 bits (294), Expect = 4e-27
Identities = 74/264 (28%), Positives = 142/264 (53%), Gaps = 13/264 (4%)
Query: 314 HKHPPKRQGDILEGPTRESAFRVYLAEYRNASKNDKLSILACKVIDTSTAP-RDFVKKFL 372
H+ Q ++L+ + S +V+L + S +D + A KV+ +T RD V+ +
Sbjct: 59 HEKADPSQFELLKVLGQGSFGKVFLV--KKISGSDARQLYAMKVLKKATLKVRDRVRTKM 116
Query: 373 PREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTR 432
R+I L++++HP +V H FQ K ++ + ++ GDL + + E+ + +
Sbjct: 117 ERDI--LVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA 174
Query: 433 QLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSL 492
+LALA+ ++H L I +RD+K EN+LL ++KL+DFG ++ +D +E ++ +FCG++
Sbjct: 175 ELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESID---HEKKAYSFCGTV 231
Query: 493 SYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRY 552
Y APE++ + + D WS G++++ ML +PF+ K K+ + K +
Sbjct: 232 EYMAPEVVNRRGH-TQSADWWSFGVLMFEMLTGTLPFQGKDRKE----TMTMILKAKLGM 286
Query: 553 IDTISDNCKRLIGLMLEPNHQNRL 576
+S + L+ ++ + N NRL
Sbjct: 287 PQFLSPEAQSLLRMLFKRNPANRL 310
Score = 60.5 bits (140), Expect = 2e-08
Identities = 46/162 (28%), Positives = 80/162 (49%), Gaps = 23/162 (14%)
Query: 16 TKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKST---LACKIIETAKAPKDFVVKFLPREI 72
T GY+L + +G G+Y+ K HK+T A KII+ +K EI
Sbjct: 418 TDGYELKEDIGVGSYSVC-------KRCIHKATNMEFAVKIIDKSKRDPT-------EEI 463
Query: 73 DVLVRLN-HPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLA 131
++L+R HP++I ++ ++ KY + + G+LL IL+ SE +A +
Sbjct: 464 EILLRYGQHPNIITLNDVYD-DGKYVYVVTLMKGGELLDKILRQKFFSEREASAVLFTIT 522
Query: 132 LGLQYLHELEIAHRDIKCENVLLTANF----NVKLSDFGFSR 169
++YLH + HRD+K N+L ++++ DFGF++
Sbjct: 523 KTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAK 564
Score = 55.2 bits (127), Expect = 7e-07
Identities = 30/113 (26%), Positives = 61/113 (53%), Gaps = 6/113 (5%)
Query: 366 DFVKKFLPREIEMLIKLS-HPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQE 424
D K+ EIE+L++ HP+++ + ++ KY + M+ G+LL+ +L++ E
Sbjct: 453 DKSKRDPTEEIEILLRYGQHPNIITLNDVYDDG-KYVYVVTLMKGGELLDKILRQKFFSE 511
Query: 425 DQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTAN----QNVKLSDFGFAR 473
+A + ++Y+H + HRD+K N+L +++++ DFGFA+
Sbjct: 512 REASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAK 564
>CR536566-1|CAG38803.1| 745|Homo sapiens RPS6KA6 protein.
Length = 745
Score = 136 bits (330), Expect = 2e-31
Identities = 77/259 (29%), Positives = 144/259 (55%), Gaps = 10/259 (3%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
++L K +G+G++ KV+L + D+ + A K+++ A V+ E D+LV +
Sbjct: 73 FELLKVLGQGSFGKVFLVRKKTGPDAGQ-LYAMKVLKKASLKVRGRVR-TKMERDILVEV 130
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP ++ +H FQ + K Y+ + + GD+ + + K +E + + +LAL L +LH
Sbjct: 131 NHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLH 190
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
+L I +RD+K EN+LL ++KL+DFG S+ ES +Q + ++CG++ Y APE++
Sbjct: 191 QLGIVYRDLKPENILLDEIGHIKLTDFGLSK---ESVDQEKKAYSFCGTVEYMAPEVVNR 247
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ + + D WS GV++F ML ++PF K + M + + + +LS E ++
Sbjct: 248 RGH-SQSADWWSYGVLMFEMLTGTLPFQG----KDRNETMNMILKAKLGMPQLLSAEAQS 302
Query: 259 VVKHLLEPDPGLRHSATNV 277
+++ L + +P R + V
Sbjct: 303 LLRMLFKRNPANRLGSEGV 321
Score = 113 bits (273), Expect = 1e-24
Identities = 72/257 (28%), Positives = 137/257 (53%), Gaps = 13/257 (5%)
Query: 321 QGDILEGPTRESAFRVYLAEYRNASKNDKLSILACKVID-TSTAPRDFVKKFLPREIEML 379
Q ++L+ + S +V+L R + D + A KV+ S R V+ + R+I L
Sbjct: 72 QFELLKVLGQGSFGKVFLV--RKKTGPDAGQLYAMKVLKKASLKVRGRVRTKMERDI--L 127
Query: 380 IKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQ 439
++++HP +V H FQ K ++ + ++ GD+ + + E+ + + +LALA+
Sbjct: 128 VEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALD 187
Query: 440 YMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEI 499
++H+L I +RD+K EN+LL ++KL+DFG ++ VD+ E ++ +FCG++ Y APE+
Sbjct: 188 HLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQ---EKKAYSFCGTVEYMAPEV 244
Query: 500 LQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDN 559
+ + + D WS G++++ ML +PF+ K +N K + +S
Sbjct: 245 VNRRGH-SQSADWWSYGVLMFEMLTGTLPFQGKD----RNETMNMILKAKLGMPQLLSAE 299
Query: 560 CKRLIGLMLEPNHQNRL 576
+ L+ ++ + N NRL
Sbjct: 300 AQSLLRMLFKRNPANRL 316
Score = 99.1 bits (236), Expect = 4e-20
Identities = 78/269 (28%), Positives = 128/269 (47%), Gaps = 22/269 (8%)
Query: 38 YSSKEDSHKSTLA-CKIIETAKAPKDFVVKFLPR-------EIDVLVRLN-HPHLIHVHS 88
Y KED + + CK A +F VK + + EI++L+R HP++I +
Sbjct: 426 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNIITLKD 485
Query: 89 IFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLHELEIAHRDIK 148
+F Y+ + G+LL ILK C SE +A ++ + YLH + HRD+K
Sbjct: 486 VFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLK 545
Query: 149 CENVLL----TANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRGKPYCPK 204
N+L + ++++ DFGF++ + +N +L T C + ++ APE+L + Y
Sbjct: 546 PSNILYMDESASADSIRICDFGFAK-QLRGENGLLL--TPCYTANFVAPEVLMQQGY-DA 601
Query: 205 PTDLWSLGVVLFVMLNKSMPF----DDTRMRKLYEQQMGKKYRFRSRVASILSLECKTVV 260
D+WSLGV+ + ML PF +DT L G K+ +S K ++
Sbjct: 602 ACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNG-KFSLSGGNWDNISDGAKDLL 660
Query: 261 KHLLEPDPGLRHSATNVLDSEWIAMDSRL 289
H+L DP R++A +L WI +L
Sbjct: 661 SHMLHMDPHQRYTAEQILKHSWITHRDQL 689
Score = 83.8 bits (198), Expect = 2e-15
Identities = 64/237 (27%), Positives = 110/237 (46%), Gaps = 14/237 (5%)
Query: 366 DFVKKFLPREIEMLIKLS-HPHLVHTHSIFQR-RYKYFIFMRYMERGDLLEFVLQRGAVQ 423
D K+ EIE+L++ HP+++ +F RY Y + M+ G+LL+ +L++
Sbjct: 458 DKSKRDPSEEIEILMRYGQHPNIITLKDVFDDGRYVYLV-TDLMKGGELLDRILKQKCFS 516
Query: 424 EDQARIWTRQLALAIQYMHELEIAHRDIKCENVLL----TANQNVKLSDFGFARMCVDKK 479
E +A ++ + Y+H + HRD+K N+L + ++++ DFGFA+ +
Sbjct: 517 EREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQL--RG 574
Query: 480 LNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQ 539
N + T C + ++ APE+L Y D+WSLG++ Y ML PF + +
Sbjct: 575 ENGLLL-TPCYTANFVAPEVLMQQGY-DAACDIWSLGVLFYTMLAGYTPFANGPNDTPEE 632
Query: 540 AQI---NKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRL 593
+ N + D ISD K L+ ML + R I+ WI +L
Sbjct: 633 ILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSWITHRDQL 689
>CR536517-1|CAG38755.1| 556|Homo sapiens PDPK1 protein.
Length = 556
Score = 136 bits (330), Expect = 2e-31
Identities = 72/237 (30%), Positives = 131/237 (55%), Gaps = 6/237 (2%)
Query: 8 PSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKF 67
P + + +K K +GEG+++ V L ++E + A KI+E K+ V +
Sbjct: 71 PPQPRKKRPEDFKFGKILGEGSFSTVVL----ARELATSREYAIKILEKRHIIKENKVPY 126
Query: 68 LPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWT 127
+ RE DV+ RL+HP + ++ FQ K Y + Y +NG+LL YI K G E R +T
Sbjct: 127 VTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYT 186
Query: 128 RQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGS 187
++ L+YLH I HRD+K EN+LL + +++++DFG ++ + +++ + ++ G+
Sbjct: 187 AEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAK-VLSPESKQARANSFVGT 245
Query: 188 MSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRF 244
Y +PE+L K C K +DLW+LG +++ ++ PF ++++ + +Y F
Sbjct: 246 AQYVSPELLTEKSAC-KSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDF 301
Score = 112 bits (270), Expect = 3e-24
Identities = 56/213 (26%), Positives = 116/213 (54%), Gaps = 2/213 (0%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLL 413
A K+++ ++ ++ RE +++ +L HP V + FQ K + + Y + G+LL
Sbjct: 109 AIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELL 168
Query: 414 EFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFAR 473
+++ + G+ E R +T ++ A++Y+H I HRD+K EN+LL + +++++DFG A+
Sbjct: 169 KYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAK 228
Query: 474 MCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKH 533
+ + + + R+ +F G+ Y +PE+L K +D+W+LG ++Y ++ PF +
Sbjct: 229 V-LSPESKQARANSFVGTAQYVSPELLTEKSAC-KSSDLWALGCIIYQLVAGLPPFRAGN 286
Query: 534 IKQLHQAQINKNWKFRSRYIDTISDNCKRLIGL 566
+ Q I + F ++ D ++L+ L
Sbjct: 287 EYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVL 319
>BC096302-1|AAH96302.1| 740|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 3 protein.
Length = 740
Score = 136 bits (330), Expect = 2e-31
Identities = 76/256 (29%), Positives = 143/256 (55%), Gaps = 10/256 (3%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
++L K +G+G++ KV+L + S D+ + A K+++ A V+ E D+LV +
Sbjct: 68 FELLKVLGQGSFGKVFLVKKISGSDA-RQLYAMKVLKKATLKVRDRVR-TKMERDILVEV 125
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP ++ +H FQ + K Y+ + + GDL + + K +E + + +LAL L +LH
Sbjct: 126 NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLH 185
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
L I +RD+K EN+LL ++KL+DFG S+ ++ + + + ++CG++ Y APE++
Sbjct: 186 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKK---AYSFCGTVEYMAPEVVNR 242
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ + + D WS GV++F ML ++PF K ++ M + + + LS E ++
Sbjct: 243 RGH-TQSADWWSFGVLMFEMLTGTLPFQG----KDRKETMTMILKAKLGMPQFLSPEAQS 297
Query: 259 VVKHLLEPDPGLRHSA 274
+++ L + +P R A
Sbjct: 298 LLRMLFKRNPANRLGA 313
Score = 122 bits (294), Expect = 4e-27
Identities = 74/264 (28%), Positives = 142/264 (53%), Gaps = 13/264 (4%)
Query: 314 HKHPPKRQGDILEGPTRESAFRVYLAEYRNASKNDKLSILACKVIDTSTAP-RDFVKKFL 372
H+ Q ++L+ + S +V+L + S +D + A KV+ +T RD V+ +
Sbjct: 60 HEKADPSQFELLKVLGQGSFGKVFLV--KKISGSDARQLYAMKVLKKATLKVRDRVRTKM 117
Query: 373 PREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTR 432
R+I L++++HP +V H FQ K ++ + ++ GDL + + E+ + +
Sbjct: 118 ERDI--LVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA 175
Query: 433 QLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSL 492
+LALA+ ++H L I +RD+K EN+LL ++KL+DFG ++ +D +E ++ +FCG++
Sbjct: 176 ELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESID---HEKKAYSFCGTV 232
Query: 493 SYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRY 552
Y APE++ + + D WS G++++ ML +PF+ K K+ + K +
Sbjct: 233 EYMAPEVVNRRGH-TQSADWWSFGVLMFEMLTGTLPFQGKDRKE----TMTMILKAKLGM 287
Query: 553 IDTISDNCKRLIGLMLEPNHQNRL 576
+S + L+ ++ + N NRL
Sbjct: 288 PQFLSPEAQSLLRMLFKRNPANRL 311
Score = 99.1 bits (236), Expect = 4e-20
Identities = 82/280 (29%), Positives = 134/280 (47%), Gaps = 31/280 (11%)
Query: 16 TKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKST---LACKIIETAKAPKDFVVKFLPREI 72
T GY++ + +G G+Y+ K HK+T A KII+ +K EI
Sbjct: 419 TDGYEVKEDIGVGSYSVC-------KRCIHKATNMEFAVKIIDKSKRDPT-------EEI 464
Query: 73 DVLVRLN-HPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLA 131
++L+R HP++I + ++ Y+ + G+LL IL+ SE +A +
Sbjct: 465 EILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTIT 524
Query: 132 LGLQYLHELEIAHRDIKCENVLLTANF----NVKLSDFGFSRFCVESDNQPVLSETYCGS 187
++YLH + HRD+K N+L ++++ DFGF++ + ++N L T C +
Sbjct: 525 KTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAK-QLRAENG--LLMTPCYT 581
Query: 188 MSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPF----DDTRMRKLYEQQMGKKYR 243
++ APE+L+ + Y D+WSLGV+L+ ML PF DDT L G K+
Sbjct: 582 ANFVAPEVLKRQGY-DAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSG-KFS 639
Query: 244 FRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+ +S K +V +L DP R +A VL WI
Sbjct: 640 LSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 679
Score = 89.4 bits (212), Expect = 3e-17
Identities = 58/230 (25%), Positives = 112/230 (48%), Gaps = 12/230 (5%)
Query: 366 DFVKKFLPREIEMLIKLS-HPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQE 424
D K+ EIE+L++ HP+++ ++ ++ M+ G+LL+ +L++ E
Sbjct: 454 DKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSE 513
Query: 425 DQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTAN----QNVKLSDFGFARMCVDKKL 480
+A + ++Y+H + HRD+K N+L +++++ DFGFA+ +
Sbjct: 514 REASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQL--RAE 571
Query: 481 NEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPF---EDKHIKQL 537
N + T C + ++ APE+L+ Y D+WSLG+++Y ML PF D +++
Sbjct: 572 NGLLM-TPCYTANFVAPEVLKRQGY-DAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEI 629
Query: 538 HQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+ + Y +++SD K L+ ML + RL ++ WI
Sbjct: 630 LARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 679
>BC096301-1|AAH96301.1| 740|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 3 protein.
Length = 740
Score = 136 bits (330), Expect = 2e-31
Identities = 76/256 (29%), Positives = 143/256 (55%), Gaps = 10/256 (3%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
++L K +G+G++ KV+L + S D+ + A K+++ A V+ E D+LV +
Sbjct: 68 FELLKVLGQGSFGKVFLVKKISGSDA-RQLYAMKVLKKATLKVRDRVR-TKMERDILVEV 125
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP ++ +H FQ + K Y+ + + GDL + + K +E + + +LAL L +LH
Sbjct: 126 NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLH 185
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
L I +RD+K EN+LL ++KL+DFG S+ ++ + + + ++CG++ Y APE++
Sbjct: 186 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKK---AYSFCGTVEYMAPEVVNR 242
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ + + D WS GV++F ML ++PF K ++ M + + + LS E ++
Sbjct: 243 RGH-TQSADWWSFGVLMFEMLTGTLPFQG----KDRKETMTMILKAKLGMPQFLSPEAQS 297
Query: 259 VVKHLLEPDPGLRHSA 274
+++ L + +P R A
Sbjct: 298 LLRMLFKRNPANRLGA 313
Score = 122 bits (294), Expect = 4e-27
Identities = 74/264 (28%), Positives = 142/264 (53%), Gaps = 13/264 (4%)
Query: 314 HKHPPKRQGDILEGPTRESAFRVYLAEYRNASKNDKLSILACKVIDTSTAP-RDFVKKFL 372
H+ Q ++L+ + S +V+L + S +D + A KV+ +T RD V+ +
Sbjct: 60 HEKADPSQFELLKVLGQGSFGKVFLV--KKISGSDARQLYAMKVLKKATLKVRDRVRTKM 117
Query: 373 PREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTR 432
R+I L++++HP +V H FQ K ++ + ++ GDL + + E+ + +
Sbjct: 118 ERDI--LVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA 175
Query: 433 QLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSL 492
+LALA+ ++H L I +RD+K EN+LL ++KL+DFG ++ +D +E ++ +FCG++
Sbjct: 176 ELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESID---HEKKAYSFCGTV 232
Query: 493 SYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRY 552
Y APE++ + + D WS G++++ ML +PF+ K K+ + K +
Sbjct: 233 EYMAPEVVNRRGH-TQSADWWSFGVLMFEMLTGTLPFQGKDRKE----TMTMILKAKLGM 287
Query: 553 IDTISDNCKRLIGLMLEPNHQNRL 576
+S + L+ ++ + N NRL
Sbjct: 288 PQFLSPEAQSLLRMLFKRNPANRL 311
Score = 99.1 bits (236), Expect = 4e-20
Identities = 82/280 (29%), Positives = 134/280 (47%), Gaps = 31/280 (11%)
Query: 16 TKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKST---LACKIIETAKAPKDFVVKFLPREI 72
T GY++ + +G G+Y+ K HK+T A KII+ +K EI
Sbjct: 419 TDGYEVKEDIGVGSYSVC-------KRCIHKATNMEFAVKIIDKSKRDPT-------EEI 464
Query: 73 DVLVRLN-HPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLA 131
++L+R HP++I + ++ Y+ + G+LL IL+ SE +A +
Sbjct: 465 EILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTIT 524
Query: 132 LGLQYLHELEIAHRDIKCENVLLTANF----NVKLSDFGFSRFCVESDNQPVLSETYCGS 187
++YLH + HRD+K N+L ++++ DFGF++ + ++N L T C +
Sbjct: 525 KTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAK-QLRAENG--LLMTPCYT 581
Query: 188 MSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPF----DDTRMRKLYEQQMGKKYR 243
++ APE+L+ + Y D+WSLGV+L+ ML PF DDT L G K+
Sbjct: 582 ANFVAPEVLKRQGY-DAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSG-KFS 639
Query: 244 FRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+ +S K +V +L DP R +A VL WI
Sbjct: 640 LSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 679
Score = 89.4 bits (212), Expect = 3e-17
Identities = 58/230 (25%), Positives = 112/230 (48%), Gaps = 12/230 (5%)
Query: 366 DFVKKFLPREIEMLIKLS-HPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQE 424
D K+ EIE+L++ HP+++ ++ ++ M+ G+LL+ +L++ E
Sbjct: 454 DKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSE 513
Query: 425 DQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTAN----QNVKLSDFGFARMCVDKKL 480
+A + ++Y+H + HRD+K N+L +++++ DFGFA+ +
Sbjct: 514 REASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQL--RAE 571
Query: 481 NEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPF---EDKHIKQL 537
N + T C + ++ APE+L+ Y D+WSLG+++Y ML PF D +++
Sbjct: 572 NGLLM-TPCYTANFVAPEVLKRQGY-DAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEI 629
Query: 538 HQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+ + Y +++SD K L+ ML + RL ++ WI
Sbjct: 630 LARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 679
>BC012103-1|AAH12103.1| 556|Homo sapiens 3-phosphoinositide
dependent protein kinase-1 protein.
Length = 556
Score = 136 bits (330), Expect = 2e-31
Identities = 72/237 (30%), Positives = 131/237 (55%), Gaps = 6/237 (2%)
Query: 8 PSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKF 67
P + + +K K +GEG+++ V L ++E + A KI+E K+ V +
Sbjct: 71 PPQPRKKRPEDFKFGKILGEGSFSTVVL----ARELATSREYAIKILEKRHIIKENKVPY 126
Query: 68 LPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWT 127
+ RE DV+ RL+HP + ++ FQ K Y + Y +NG+LL YI K G E R +T
Sbjct: 127 VTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYT 186
Query: 128 RQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGS 187
++ L+YLH I HRD+K EN+LL + +++++DFG ++ + +++ + ++ G+
Sbjct: 187 AEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAK-VLSPESKQARANSFVGT 245
Query: 188 MSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRF 244
Y +PE+L K C K +DLW+LG +++ ++ PF ++++ + +Y F
Sbjct: 246 AQYVSPELLTEKSAC-KSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDF 301
Score = 112 bits (270), Expect = 3e-24
Identities = 56/213 (26%), Positives = 116/213 (54%), Gaps = 2/213 (0%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLL 413
A K+++ ++ ++ RE +++ +L HP V + FQ K + + Y + G+LL
Sbjct: 109 AIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELL 168
Query: 414 EFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFAR 473
+++ + G+ E R +T ++ A++Y+H I HRD+K EN+LL + +++++DFG A+
Sbjct: 169 KYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAK 228
Query: 474 MCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKH 533
+ + + + R+ +F G+ Y +PE+L K +D+W+LG ++Y ++ PF +
Sbjct: 229 V-LSPESKQARANSFVGTAQYVSPELLTEKSAC-KSSDLWALGCIIYQLVAGLPPFRAGN 286
Query: 534 IKQLHQAQINKNWKFRSRYIDTISDNCKRLIGL 566
+ Q I + F ++ D ++L+ L
Sbjct: 287 EYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVL 319
>AL807772-3|CAI39687.1| 740|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 3 protein.
Length = 740
Score = 136 bits (330), Expect = 2e-31
Identities = 76/256 (29%), Positives = 143/256 (55%), Gaps = 10/256 (3%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
++L K +G+G++ KV+L + S D+ + A K+++ A V+ E D+LV +
Sbjct: 68 FELLKVLGQGSFGKVFLVKKISGSDA-RQLYAMKVLKKATLKVRDRVR-TKMERDILVEV 125
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP ++ +H FQ + K Y+ + + GDL + + K +E + + +LAL L +LH
Sbjct: 126 NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLH 185
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
L I +RD+K EN+LL ++KL+DFG S+ ++ + + + ++CG++ Y APE++
Sbjct: 186 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKK---AYSFCGTVEYMAPEVVNR 242
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ + + D WS GV++F ML ++PF K ++ M + + + LS E ++
Sbjct: 243 RGH-TQSADWWSFGVLMFEMLTGTLPFQG----KDRKETMTMILKAKLGMPQFLSPEAQS 297
Query: 259 VVKHLLEPDPGLRHSA 274
+++ L + +P R A
Sbjct: 298 LLRMLFKRNPANRLGA 313
Score = 122 bits (294), Expect = 4e-27
Identities = 74/264 (28%), Positives = 142/264 (53%), Gaps = 13/264 (4%)
Query: 314 HKHPPKRQGDILEGPTRESAFRVYLAEYRNASKNDKLSILACKVIDTSTAP-RDFVKKFL 372
H+ Q ++L+ + S +V+L + S +D + A KV+ +T RD V+ +
Sbjct: 60 HEKADPSQFELLKVLGQGSFGKVFLV--KKISGSDARQLYAMKVLKKATLKVRDRVRTKM 117
Query: 373 PREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTR 432
R+I L++++HP +V H FQ K ++ + ++ GDL + + E+ + +
Sbjct: 118 ERDI--LVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA 175
Query: 433 QLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSL 492
+LALA+ ++H L I +RD+K EN+LL ++KL+DFG ++ +D +E ++ +FCG++
Sbjct: 176 ELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESID---HEKKAYSFCGTV 232
Query: 493 SYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRY 552
Y APE++ + + D WS G++++ ML +PF+ K K+ + K +
Sbjct: 233 EYMAPEVVNRRGH-TQSADWWSFGVLMFEMLTGTLPFQGKDRKE----TMTMILKAKLGM 287
Query: 553 IDTISDNCKRLIGLMLEPNHQNRL 576
+S + L+ ++ + N NRL
Sbjct: 288 PQFLSPEAQSLLRMLFKRNPANRL 311
Score = 99.1 bits (236), Expect = 4e-20
Identities = 82/280 (29%), Positives = 134/280 (47%), Gaps = 31/280 (11%)
Query: 16 TKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKST---LACKIIETAKAPKDFVVKFLPREI 72
T GY++ + +G G+Y+ K HK+T A KII+ +K EI
Sbjct: 419 TDGYEVKEDIGVGSYSVC-------KRCIHKATNMEFAVKIIDKSKRDPT-------EEI 464
Query: 73 DVLVRLN-HPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLA 131
++L+R HP++I + ++ Y+ + G+LL IL+ SE +A +
Sbjct: 465 EILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTIT 524
Query: 132 LGLQYLHELEIAHRDIKCENVLLTANF----NVKLSDFGFSRFCVESDNQPVLSETYCGS 187
++YLH + HRD+K N+L ++++ DFGF++ + ++N L T C +
Sbjct: 525 KTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAK-QLRAENG--LLMTPCYT 581
Query: 188 MSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPF----DDTRMRKLYEQQMGKKYR 243
++ APE+L+ + Y D+WSLGV+L+ ML PF DDT L G K+
Sbjct: 582 ANFVAPEVLKRQGY-DAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSG-KFS 639
Query: 244 FRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+ +S K +V +L DP R +A VL WI
Sbjct: 640 LSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 679
Score = 89.4 bits (212), Expect = 3e-17
Identities = 58/230 (25%), Positives = 112/230 (48%), Gaps = 12/230 (5%)
Query: 366 DFVKKFLPREIEMLIKLS-HPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQE 424
D K+ EIE+L++ HP+++ ++ ++ M+ G+LL+ +L++ E
Sbjct: 454 DKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSE 513
Query: 425 DQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTAN----QNVKLSDFGFARMCVDKKL 480
+A + ++Y+H + HRD+K N+L +++++ DFGFA+ +
Sbjct: 514 REASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQL--RAE 571
Query: 481 NEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPF---EDKHIKQL 537
N + T C + ++ APE+L+ Y D+WSLG+++Y ML PF D +++
Sbjct: 572 NGLLM-TPCYTANFVAPEVLKRQGY-DAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEI 629
Query: 538 HQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+ + Y +++SD K L+ ML + RL ++ WI
Sbjct: 630 LARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 679
>AL732366-2|CAI40548.1| 740|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 3 protein.
Length = 740
Score = 136 bits (330), Expect = 2e-31
Identities = 76/256 (29%), Positives = 143/256 (55%), Gaps = 10/256 (3%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
++L K +G+G++ KV+L + S D+ + A K+++ A V+ E D+LV +
Sbjct: 68 FELLKVLGQGSFGKVFLVKKISGSDA-RQLYAMKVLKKATLKVRDRVR-TKMERDILVEV 125
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP ++ +H FQ + K Y+ + + GDL + + K +E + + +LAL L +LH
Sbjct: 126 NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLH 185
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
L I +RD+K EN+LL ++KL+DFG S+ ++ + + + ++CG++ Y APE++
Sbjct: 186 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKK---AYSFCGTVEYMAPEVVNR 242
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ + + D WS GV++F ML ++PF K ++ M + + + LS E ++
Sbjct: 243 RGH-TQSADWWSFGVLMFEMLTGTLPFQG----KDRKETMTMILKAKLGMPQFLSPEAQS 297
Query: 259 VVKHLLEPDPGLRHSA 274
+++ L + +P R A
Sbjct: 298 LLRMLFKRNPANRLGA 313
Score = 122 bits (294), Expect = 4e-27
Identities = 74/264 (28%), Positives = 142/264 (53%), Gaps = 13/264 (4%)
Query: 314 HKHPPKRQGDILEGPTRESAFRVYLAEYRNASKNDKLSILACKVIDTSTAP-RDFVKKFL 372
H+ Q ++L+ + S +V+L + S +D + A KV+ +T RD V+ +
Sbjct: 60 HEKADPSQFELLKVLGQGSFGKVFLV--KKISGSDARQLYAMKVLKKATLKVRDRVRTKM 117
Query: 373 PREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTR 432
R+I L++++HP +V H FQ K ++ + ++ GDL + + E+ + +
Sbjct: 118 ERDI--LVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA 175
Query: 433 QLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSL 492
+LALA+ ++H L I +RD+K EN+LL ++KL+DFG ++ +D +E ++ +FCG++
Sbjct: 176 ELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESID---HEKKAYSFCGTV 232
Query: 493 SYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRY 552
Y APE++ + + D WS G++++ ML +PF+ K K+ + K +
Sbjct: 233 EYMAPEVVNRRGH-TQSADWWSFGVLMFEMLTGTLPFQGKDRKE----TMTMILKAKLGM 287
Query: 553 IDTISDNCKRLIGLMLEPNHQNRL 576
+S + L+ ++ + N NRL
Sbjct: 288 PQFLSPEAQSLLRMLFKRNPANRL 311
Score = 99.1 bits (236), Expect = 4e-20
Identities = 82/280 (29%), Positives = 134/280 (47%), Gaps = 31/280 (11%)
Query: 16 TKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKST---LACKIIETAKAPKDFVVKFLPREI 72
T GY++ + +G G+Y+ K HK+T A KII+ +K EI
Sbjct: 419 TDGYEVKEDIGVGSYSVC-------KRCIHKATNMEFAVKIIDKSKRDPT-------EEI 464
Query: 73 DVLVRLN-HPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLA 131
++L+R HP++I + ++ Y+ + G+LL IL+ SE +A +
Sbjct: 465 EILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTIT 524
Query: 132 LGLQYLHELEIAHRDIKCENVLLTANF----NVKLSDFGFSRFCVESDNQPVLSETYCGS 187
++YLH + HRD+K N+L ++++ DFGF++ + ++N L T C +
Sbjct: 525 KTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAK-QLRAENG--LLMTPCYT 581
Query: 188 MSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPF----DDTRMRKLYEQQMGKKYR 243
++ APE+L+ + Y D+WSLGV+L+ ML PF DDT L G K+
Sbjct: 582 ANFVAPEVLKRQGY-DAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSG-KFS 639
Query: 244 FRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+ +S K +V +L DP R +A VL WI
Sbjct: 640 LSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 679
Score = 89.4 bits (212), Expect = 3e-17
Identities = 58/230 (25%), Positives = 112/230 (48%), Gaps = 12/230 (5%)
Query: 366 DFVKKFLPREIEMLIKLS-HPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQE 424
D K+ EIE+L++ HP+++ ++ ++ M+ G+LL+ +L++ E
Sbjct: 454 DKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSE 513
Query: 425 DQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTAN----QNVKLSDFGFARMCVDKKL 480
+A + ++Y+H + HRD+K N+L +++++ DFGFA+ +
Sbjct: 514 REASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQL--RAE 571
Query: 481 NEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPF---EDKHIKQL 537
N + T C + ++ APE+L+ Y D+WSLG+++Y ML PF D +++
Sbjct: 572 NGLLM-TPCYTANFVAPEVLKRQGY-DAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEI 629
Query: 538 HQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+ + Y +++SD K L+ ML + RL ++ WI
Sbjct: 630 LARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 679
>AF017995-1|AAC51825.1| 556|Homo sapiens 3-phosphoinositide
dependent protein kinase-1 protein.
Length = 556
Score = 136 bits (330), Expect = 2e-31
Identities = 72/237 (30%), Positives = 131/237 (55%), Gaps = 6/237 (2%)
Query: 8 PSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKF 67
P + + +K K +GEG+++ V L ++E + A KI+E K+ V +
Sbjct: 71 PPQPRKKRPEDFKFGKILGEGSFSTVVL----ARELATSREYAIKILEKRHIIKENKVPY 126
Query: 68 LPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWT 127
+ RE DV+ RL+HP + ++ FQ K Y + Y +NG+LL YI K G E R +T
Sbjct: 127 VTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYT 186
Query: 128 RQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGS 187
++ L+YLH I HRD+K EN+LL + +++++DFG ++ + +++ + ++ G+
Sbjct: 187 AEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAK-VLSPESKQARANSFVGT 245
Query: 188 MSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRF 244
Y +PE+L K C K +DLW+LG +++ ++ PF ++++ + +Y F
Sbjct: 246 AQYVSPELLTEKSAC-KSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDF 301
Score = 112 bits (270), Expect = 3e-24
Identities = 56/213 (26%), Positives = 116/213 (54%), Gaps = 2/213 (0%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLL 413
A K+++ ++ ++ RE +++ +L HP V + FQ K + + Y + G+LL
Sbjct: 109 AIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELL 168
Query: 414 EFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFAR 473
+++ + G+ E R +T ++ A++Y+H I HRD+K EN+LL + +++++DFG A+
Sbjct: 169 KYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAK 228
Query: 474 MCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKH 533
+ + + + R+ +F G+ Y +PE+L K +D+W+LG ++Y ++ PF +
Sbjct: 229 V-LSPESKQARANSFVGTAQYVSPELLTEKSAC-KSSDLWALGCIIYQLVAGLPPFRAGN 286
Query: 534 IKQLHQAQINKNWKFRSRYIDTISDNCKRLIGL 566
+ Q I + F ++ D ++L+ L
Sbjct: 287 EYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVL 319
>AC005591-1|AAC33797.1| 367|Homo sapiens PkB-like protein.
Length = 367
Score = 136 bits (330), Expect = 2e-31
Identities = 72/237 (30%), Positives = 131/237 (55%), Gaps = 6/237 (2%)
Query: 8 PSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKF 67
P + + +K K +GEG+++ V L ++E + A KI+E K+ V +
Sbjct: 63 PPQPRKKRPEDFKFGKILGEGSFSTVVL----ARELATSREYAIKILEKRHIIKENKVPY 118
Query: 68 LPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWT 127
+ RE DV+ RL+HP + ++ FQ K Y + Y +NG+LL YI K G E R +T
Sbjct: 119 VTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYT 178
Query: 128 RQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGS 187
++ L+YLH I HRD+K EN+LL + +++++DFG ++ + +++ + ++ G+
Sbjct: 179 AEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAK-VLSPESKQARANSFVGT 237
Query: 188 MSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRF 244
Y +PE+L K C K +DLW+LG +++ ++ PF ++++ + +Y F
Sbjct: 238 AQYVSPELLTEKSAC-KSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDF 293
Score = 112 bits (270), Expect = 3e-24
Identities = 56/213 (26%), Positives = 116/213 (54%), Gaps = 2/213 (0%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLL 413
A K+++ ++ ++ RE +++ +L HP V + FQ K + + Y + G+LL
Sbjct: 101 AIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELL 160
Query: 414 EFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFAR 473
+++ + G+ E R +T ++ A++Y+H I HRD+K EN+LL + +++++DFG A+
Sbjct: 161 KYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAK 220
Query: 474 MCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKH 533
+ + + + R+ +F G+ Y +PE+L K +D+W+LG ++Y ++ PF +
Sbjct: 221 V-LSPESKQARANSFVGTAQYVSPELLTEKSAC-KSSDLWALGCIIYQLVAGLPPFRAGN 278
Query: 534 IKQLHQAQINKNWKFRSRYIDTISDNCKRLIGL 566
+ Q I + F ++ D ++L+ L
Sbjct: 279 EYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVL 311
>AB209835-1|BAD93072.1| 492|Homo sapiens 3-phosphoinositide
dependent protein kinase-1 variant protein.
Length = 492
Score = 136 bits (330), Expect = 2e-31
Identities = 72/237 (30%), Positives = 131/237 (55%), Gaps = 6/237 (2%)
Query: 8 PSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKF 67
P + + +K K +GEG+++ V L ++E + A KI+E K+ V +
Sbjct: 109 PPQPRKKRPEDFKFGKILGEGSFSTVVL----ARELATSREYAIKILEKRHIIKENKVPY 164
Query: 68 LPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWT 127
+ RE DV+ RL+HP + ++ FQ K Y + Y +NG+LL YI K G E R +T
Sbjct: 165 VTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYT 224
Query: 128 RQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGS 187
++ L+YLH I HRD+K EN+LL + +++++DFG ++ + +++ + ++ G+
Sbjct: 225 AEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAK-VLSPESKQARANSFVGT 283
Query: 188 MSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRF 244
Y +PE+L K C K +DLW+LG +++ ++ PF ++++ + +Y F
Sbjct: 284 AQYVSPELLTEKSAC-KSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDF 339
Score = 112 bits (270), Expect = 3e-24
Identities = 56/213 (26%), Positives = 116/213 (54%), Gaps = 2/213 (0%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLL 413
A K+++ ++ ++ RE +++ +L HP V + FQ K + + Y + G+LL
Sbjct: 147 AIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELL 206
Query: 414 EFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFAR 473
+++ + G+ E R +T ++ A++Y+H I HRD+K EN+LL + +++++DFG A+
Sbjct: 207 KYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAK 266
Query: 474 MCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKH 533
+ + + + R+ +F G+ Y +PE+L K +D+W+LG ++Y ++ PF +
Sbjct: 267 V-LSPESKQARANSFVGTAQYVSPELLTEKSAC-KSSDLWALGCIIYQLVAGLPPFRAGN 324
Query: 534 IKQLHQAQINKNWKFRSRYIDTISDNCKRLIGL 566
+ Q I + F ++ D ++L+ L
Sbjct: 325 EYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVL 357
>AB208933-1|BAD92170.1| 806|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 3 variant protein.
Length = 806
Score = 136 bits (330), Expect = 2e-31
Identities = 76/256 (29%), Positives = 143/256 (55%), Gaps = 10/256 (3%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
++L K +G+G++ KV+L + S D+ + A K+++ A V+ E D+LV +
Sbjct: 135 FELLKVLGQGSFGKVFLVKKISGSDA-RQLYAMKVLKKATLKVRDRVR-TKMERDILVEV 192
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP ++ +H FQ + K Y+ + + GDL + + K +E + + +LAL L +LH
Sbjct: 193 NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLH 252
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
L I +RD+K EN+LL ++KL+DFG S+ ++ + + + ++CG++ Y APE++
Sbjct: 253 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKK---AYSFCGTVEYMAPEVVNR 309
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ + + D WS GV++F ML ++PF K ++ M + + + LS E ++
Sbjct: 310 RGH-TQSADWWSFGVLMFEMLTGTLPFQG----KDRKETMTMILKAKLGMPQFLSPEAQS 364
Query: 259 VVKHLLEPDPGLRHSA 274
+++ L + +P R A
Sbjct: 365 LLRMLFKRNPANRLGA 380
Score = 122 bits (294), Expect = 4e-27
Identities = 74/264 (28%), Positives = 142/264 (53%), Gaps = 13/264 (4%)
Query: 314 HKHPPKRQGDILEGPTRESAFRVYLAEYRNASKNDKLSILACKVIDTSTAP-RDFVKKFL 372
H+ Q ++L+ + S +V+L + S +D + A KV+ +T RD V+ +
Sbjct: 127 HEKADPSQFELLKVLGQGSFGKVFLV--KKISGSDARQLYAMKVLKKATLKVRDRVRTKM 184
Query: 373 PREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTR 432
R+I L++++HP +V H FQ K ++ + ++ GDL + + E+ + +
Sbjct: 185 ERDI--LVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA 242
Query: 433 QLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSL 492
+LALA+ ++H L I +RD+K EN+LL ++KL+DFG ++ +D +E ++ +FCG++
Sbjct: 243 ELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESID---HEKKAYSFCGTV 299
Query: 493 SYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRY 552
Y APE++ + + D WS G++++ ML +PF+ K K+ + K +
Sbjct: 300 EYMAPEVVNRRGH-TQSADWWSFGVLMFEMLTGTLPFQGKDRKE----TMTMILKAKLGM 354
Query: 553 IDTISDNCKRLIGLMLEPNHQNRL 576
+S + L+ ++ + N NRL
Sbjct: 355 PQFLSPEAQSLLRMLFKRNPANRL 378
Score = 99.1 bits (236), Expect = 4e-20
Identities = 82/280 (29%), Positives = 134/280 (47%), Gaps = 31/280 (11%)
Query: 16 TKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKST---LACKIIETAKAPKDFVVKFLPREI 72
T GY++ + +G G+Y+ K HK+T A KII+ +K EI
Sbjct: 485 TDGYEVKEDIGVGSYSVC-------KRCIHKATNMEFAVKIIDKSKRDPT-------EEI 530
Query: 73 DVLVRLN-HPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLA 131
++L+R HP++I + ++ Y+ + G+LL IL+ SE +A +
Sbjct: 531 EILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTIT 590
Query: 132 LGLQYLHELEIAHRDIKCENVLLTANF----NVKLSDFGFSRFCVESDNQPVLSETYCGS 187
++YLH + HRD+K N+L ++++ DFGF++ + ++N L T C +
Sbjct: 591 KTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAK-QLRAENG--LLMTPCYT 647
Query: 188 MSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPF----DDTRMRKLYEQQMGKKYR 243
++ APE+L+ + Y D+WSLGV+L+ ML PF DDT L G K+
Sbjct: 648 ANFVAPEVLKRQGY-DAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSG-KFS 705
Query: 244 FRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+ +S K +V +L DP R +A VL WI
Sbjct: 706 LSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 745
Score = 89.4 bits (212), Expect = 3e-17
Identities = 58/230 (25%), Positives = 112/230 (48%), Gaps = 12/230 (5%)
Query: 366 DFVKKFLPREIEMLIKLS-HPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQE 424
D K+ EIE+L++ HP+++ ++ ++ M+ G+LL+ +L++ E
Sbjct: 520 DKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSE 579
Query: 425 DQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTAN----QNVKLSDFGFARMCVDKKL 480
+A + ++Y+H + HRD+K N+L +++++ DFGFA+ +
Sbjct: 580 REASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQL--RAE 637
Query: 481 NEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPF---EDKHIKQL 537
N + T C + ++ APE+L+ Y D+WSLG+++Y ML PF D +++
Sbjct: 638 NGLLM-TPCYTANFVAPEVLKRQGY-DAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEI 695
Query: 538 HQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+ + Y +++SD K L+ ML + RL ++ WI
Sbjct: 696 LARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 745
>AB102662-1|BAC81131.1| 726|Homo sapiens RPS6KA3 protein.
Length = 726
Score = 136 bits (330), Expect = 2e-31
Identities = 76/256 (29%), Positives = 143/256 (55%), Gaps = 10/256 (3%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
++L K +G+G++ KV+L + S D+ + A K+++ A V+ E D+LV +
Sbjct: 54 FELLKVLGQGSFGKVFLVKKISGSDA-RQLYAMKVLKKATLKVRDRVR-TKMERDILVEV 111
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP ++ +H FQ + K Y+ + + GDL + + K +E + + +LAL L +LH
Sbjct: 112 NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLH 171
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
L I +RD+K EN+LL ++KL+DFG S+ ++ + + + ++CG++ Y APE++
Sbjct: 172 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKK---AYSFCGTVEYMAPEVVNR 228
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ + + D WS GV++F ML ++PF K ++ M + + + LS E ++
Sbjct: 229 RGH-TQSADWWSFGVLMFEMLTGTLPFQG----KDRKETMTMILKAKLGMPQFLSPEAQS 283
Query: 259 VVKHLLEPDPGLRHSA 274
+++ L + +P R A
Sbjct: 284 LLRMLFKRNPANRLGA 299
Score = 122 bits (294), Expect = 4e-27
Identities = 74/264 (28%), Positives = 142/264 (53%), Gaps = 13/264 (4%)
Query: 314 HKHPPKRQGDILEGPTRESAFRVYLAEYRNASKNDKLSILACKVIDTSTAP-RDFVKKFL 372
H+ Q ++L+ + S +V+L + S +D + A KV+ +T RD V+ +
Sbjct: 46 HEKADPSQFELLKVLGQGSFGKVFLV--KKISGSDARQLYAMKVLKKATLKVRDRVRTKM 103
Query: 373 PREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTR 432
R+I L++++HP +V H FQ K ++ + ++ GDL + + E+ + +
Sbjct: 104 ERDI--LVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA 161
Query: 433 QLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSL 492
+LALA+ ++H L I +RD+K EN+LL ++KL+DFG ++ +D +E ++ +FCG++
Sbjct: 162 ELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESID---HEKKAYSFCGTV 218
Query: 493 SYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRY 552
Y APE++ + + D WS G++++ ML +PF+ K K+ + K +
Sbjct: 219 EYMAPEVVNRRGH-TQSADWWSFGVLMFEMLTGTLPFQGKDRKE----TMTMILKAKLGM 273
Query: 553 IDTISDNCKRLIGLMLEPNHQNRL 576
+S + L+ ++ + N NRL
Sbjct: 274 PQFLSPEAQSLLRMLFKRNPANRL 297
Score = 99.1 bits (236), Expect = 4e-20
Identities = 82/280 (29%), Positives = 134/280 (47%), Gaps = 31/280 (11%)
Query: 16 TKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKST---LACKIIETAKAPKDFVVKFLPREI 72
T GY++ + +G G+Y+ K HK+T A KII+ +K EI
Sbjct: 405 TDGYEVKEDIGVGSYSVC-------KRCIHKATNMEFAVKIIDKSKRDPT-------EEI 450
Query: 73 DVLVRLN-HPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLA 131
++L+R HP++I + ++ Y+ + G+LL IL+ SE +A +
Sbjct: 451 EILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTIT 510
Query: 132 LGLQYLHELEIAHRDIKCENVLLTANF----NVKLSDFGFSRFCVESDNQPVLSETYCGS 187
++YLH + HRD+K N+L ++++ DFGF++ + ++N L T C +
Sbjct: 511 KTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAK-QLRAENG--LLMTPCYT 567
Query: 188 MSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPF----DDTRMRKLYEQQMGKKYR 243
++ APE+L+ + Y D+WSLGV+L+ ML PF DDT L G K+
Sbjct: 568 ANFVAPEVLKRQGY-DAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSG-KFS 625
Query: 244 FRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+ +S K +V +L DP R +A VL WI
Sbjct: 626 LSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 665
Score = 89.4 bits (212), Expect = 3e-17
Identities = 58/230 (25%), Positives = 112/230 (48%), Gaps = 12/230 (5%)
Query: 366 DFVKKFLPREIEMLIKLS-HPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQE 424
D K+ EIE+L++ HP+++ ++ ++ M+ G+LL+ +L++ E
Sbjct: 440 DKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSE 499
Query: 425 DQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTAN----QNVKLSDFGFARMCVDKKL 480
+A + ++Y+H + HRD+K N+L +++++ DFGFA+ +
Sbjct: 500 REASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQL--RAE 557
Query: 481 NEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPF---EDKHIKQL 537
N + T C + ++ APE+L+ Y D+WSLG+++Y ML PF D +++
Sbjct: 558 NGLLM-TPCYTANFVAPEVLKRQGY-DAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEI 615
Query: 538 HQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+ + Y +++SD K L+ ML + RL ++ WI
Sbjct: 616 LARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 665
>AL389887-1|CAC16111.2| 745|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 6 protein.
Length = 745
Score = 136 bits (328), Expect = 3e-31
Identities = 77/259 (29%), Positives = 143/259 (55%), Gaps = 10/259 (3%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
++L K +G+G++ KV+L + D+ + A K+++ A V+ E D+LV +
Sbjct: 73 FELLKVLGQGSFGKVFLVRKKTGPDAGQ-LYAMKVLKKASLKVRDRVR-TKMERDILVEV 130
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP ++ +H FQ + K Y+ + + GD+ + + K +E + + +LAL L +LH
Sbjct: 131 NHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLH 190
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
+L I +RD+K EN+LL ++KL+DFG S+ ES +Q + ++CG++ Y APE++
Sbjct: 191 QLGIVYRDLKPENILLDEIGHIKLTDFGLSK---ESVDQEKKAYSFCGTVEYMAPEVVNR 247
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ + + D WS GV++F ML ++PF K + M + + + LS E ++
Sbjct: 248 RGH-SQSADWWSYGVLMFEMLTGTLPFQG----KDRNETMNMILKAKLGMPQFLSAEAQS 302
Query: 259 VVKHLLEPDPGLRHSATNV 277
+++ L + +P R + V
Sbjct: 303 LLRMLFKRNPANRLGSEGV 321
Score = 116 bits (279), Expect = 3e-25
Identities = 73/257 (28%), Positives = 138/257 (53%), Gaps = 13/257 (5%)
Query: 321 QGDILEGPTRESAFRVYLAEYRNASKNDKLSILACKVID-TSTAPRDFVKKFLPREIEML 379
Q ++L+ + S +V+L R + D + A KV+ S RD V+ + R+I L
Sbjct: 72 QFELLKVLGQGSFGKVFLV--RKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDI--L 127
Query: 380 IKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQ 439
++++HP +V H FQ K ++ + ++ GD+ + + E+ + + +LALA+
Sbjct: 128 VEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALD 187
Query: 440 YMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEI 499
++H+L I +RD+K EN+LL ++KL+DFG ++ VD+ E ++ +FCG++ Y APE+
Sbjct: 188 HLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQ---EKKAYSFCGTVEYMAPEV 244
Query: 500 LQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDN 559
+ + + D WS G++++ ML +PF+ K +N K + +S
Sbjct: 245 VNRRGH-SQSADWWSYGVLMFEMLTGTLPFQGKD----RNETMNMILKAKLGMPQFLSAE 299
Query: 560 CKRLIGLMLEPNHQNRL 576
+ L+ ++ + N NRL
Sbjct: 300 AQSLLRMLFKRNPANRL 316
Score = 99.1 bits (236), Expect = 4e-20
Identities = 78/269 (28%), Positives = 128/269 (47%), Gaps = 22/269 (8%)
Query: 38 YSSKEDSHKSTLA-CKIIETAKAPKDFVVKFLPR-------EIDVLVRLN-HPHLIHVHS 88
Y KED + + CK A +F VK + + EI++L+R HP++I +
Sbjct: 426 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNIITLKD 485
Query: 89 IFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLHELEIAHRDIK 148
+F Y+ + G+LL ILK C SE +A ++ + YLH + HRD+K
Sbjct: 486 VFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLK 545
Query: 149 CENVLL----TANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRGKPYCPK 204
N+L + ++++ DFGF++ + +N +L T C + ++ APE+L + Y
Sbjct: 546 PSNILYMDESASADSIRICDFGFAK-QLRGENGLLL--TPCYTANFVAPEVLMQQGY-DA 601
Query: 205 PTDLWSLGVVLFVMLNKSMPF----DDTRMRKLYEQQMGKKYRFRSRVASILSLECKTVV 260
D+WSLGV+ + ML PF +DT L G K+ +S K ++
Sbjct: 602 ACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNG-KFSLSGGNWDNISDGAKDLL 660
Query: 261 KHLLEPDPGLRHSATNVLDSEWIAMDSRL 289
H+L DP R++A +L WI +L
Sbjct: 661 SHMLHMDPHQRYTAEQILKHSWITHRDQL 689
Score = 83.8 bits (198), Expect = 2e-15
Identities = 64/237 (27%), Positives = 110/237 (46%), Gaps = 14/237 (5%)
Query: 366 DFVKKFLPREIEMLIKLS-HPHLVHTHSIFQR-RYKYFIFMRYMERGDLLEFVLQRGAVQ 423
D K+ EIE+L++ HP+++ +F RY Y + M+ G+LL+ +L++
Sbjct: 458 DKSKRDPSEEIEILMRYGQHPNIITLKDVFDDGRYVYLV-TDLMKGGELLDRILKQKCFS 516
Query: 424 EDQARIWTRQLALAIQYMHELEIAHRDIKCENVLL----TANQNVKLSDFGFARMCVDKK 479
E +A ++ + Y+H + HRD+K N+L + ++++ DFGFA+ +
Sbjct: 517 EREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQL--RG 574
Query: 480 LNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQ 539
N + T C + ++ APE+L Y D+WSLG++ Y ML PF + +
Sbjct: 575 ENGLLL-TPCYTANFVAPEVLMQQGY-DAACDIWSLGVLFYTMLAGYTPFANGPNDTPEE 632
Query: 540 AQI---NKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRL 593
+ N + D ISD K L+ ML + R I+ WI +L
Sbjct: 633 ILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSWITHRDQL 689
>AL354653-1|CAD13486.2| 745|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 6 protein.
Length = 745
Score = 136 bits (328), Expect = 3e-31
Identities = 77/259 (29%), Positives = 143/259 (55%), Gaps = 10/259 (3%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
++L K +G+G++ KV+L + D+ + A K+++ A V+ E D+LV +
Sbjct: 73 FELLKVLGQGSFGKVFLVRKKTGPDAGQ-LYAMKVLKKASLKVRDRVR-TKMERDILVEV 130
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP ++ +H FQ + K Y+ + + GD+ + + K +E + + +LAL L +LH
Sbjct: 131 NHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLH 190
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
+L I +RD+K EN+LL ++KL+DFG S+ ES +Q + ++CG++ Y APE++
Sbjct: 191 QLGIVYRDLKPENILLDEIGHIKLTDFGLSK---ESVDQEKKAYSFCGTVEYMAPEVVNR 247
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ + + D WS GV++F ML ++PF K + M + + + LS E ++
Sbjct: 248 RGH-SQSADWWSYGVLMFEMLTGTLPFQG----KDRNETMNMILKAKLGMPQFLSAEAQS 302
Query: 259 VVKHLLEPDPGLRHSATNV 277
+++ L + +P R + V
Sbjct: 303 LLRMLFKRNPANRLGSEGV 321
Score = 116 bits (279), Expect = 3e-25
Identities = 73/257 (28%), Positives = 138/257 (53%), Gaps = 13/257 (5%)
Query: 321 QGDILEGPTRESAFRVYLAEYRNASKNDKLSILACKVID-TSTAPRDFVKKFLPREIEML 379
Q ++L+ + S +V+L R + D + A KV+ S RD V+ + R+I L
Sbjct: 72 QFELLKVLGQGSFGKVFLV--RKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDI--L 127
Query: 380 IKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQ 439
++++HP +V H FQ K ++ + ++ GD+ + + E+ + + +LALA+
Sbjct: 128 VEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALD 187
Query: 440 YMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEI 499
++H+L I +RD+K EN+LL ++KL+DFG ++ VD+ E ++ +FCG++ Y APE+
Sbjct: 188 HLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQ---EKKAYSFCGTVEYMAPEV 244
Query: 500 LQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDN 559
+ + + D WS G++++ ML +PF+ K +N K + +S
Sbjct: 245 VNRRGH-SQSADWWSYGVLMFEMLTGTLPFQGKD----RNETMNMILKAKLGMPQFLSAE 299
Query: 560 CKRLIGLMLEPNHQNRL 576
+ L+ ++ + N NRL
Sbjct: 300 AQSLLRMLFKRNPANRL 316
Score = 99.1 bits (236), Expect = 4e-20
Identities = 78/269 (28%), Positives = 128/269 (47%), Gaps = 22/269 (8%)
Query: 38 YSSKEDSHKSTLA-CKIIETAKAPKDFVVKFLPR-------EIDVLVRLN-HPHLIHVHS 88
Y KED + + CK A +F VK + + EI++L+R HP++I +
Sbjct: 426 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNIITLKD 485
Query: 89 IFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLHELEIAHRDIK 148
+F Y+ + G+LL ILK C SE +A ++ + YLH + HRD+K
Sbjct: 486 VFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLK 545
Query: 149 CENVLL----TANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRGKPYCPK 204
N+L + ++++ DFGF++ + +N +L T C + ++ APE+L + Y
Sbjct: 546 PSNILYMDESASADSIRICDFGFAK-QLRGENGLLL--TPCYTANFVAPEVLMQQGY-DA 601
Query: 205 PTDLWSLGVVLFVMLNKSMPF----DDTRMRKLYEQQMGKKYRFRSRVASILSLECKTVV 260
D+WSLGV+ + ML PF +DT L G K+ +S K ++
Sbjct: 602 ACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNG-KFSLSGGNWDNISDGAKDLL 660
Query: 261 KHLLEPDPGLRHSATNVLDSEWIAMDSRL 289
H+L DP R++A +L WI +L
Sbjct: 661 SHMLHMDPHQRYTAEQILKHSWITHRDQL 689
Score = 83.8 bits (198), Expect = 2e-15
Identities = 64/237 (27%), Positives = 110/237 (46%), Gaps = 14/237 (5%)
Query: 366 DFVKKFLPREIEMLIKLS-HPHLVHTHSIFQR-RYKYFIFMRYMERGDLLEFVLQRGAVQ 423
D K+ EIE+L++ HP+++ +F RY Y + M+ G+LL+ +L++
Sbjct: 458 DKSKRDPSEEIEILMRYGQHPNIITLKDVFDDGRYVYLV-TDLMKGGELLDRILKQKCFS 516
Query: 424 EDQARIWTRQLALAIQYMHELEIAHRDIKCENVLL----TANQNVKLSDFGFARMCVDKK 479
E +A ++ + Y+H + HRD+K N+L + ++++ DFGFA+ +
Sbjct: 517 EREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQL--RG 574
Query: 480 LNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQ 539
N + T C + ++ APE+L Y D+WSLG++ Y ML PF + +
Sbjct: 575 ENGLLL-TPCYTANFVAPEVLMQQGY-DAACDIWSLGVLFYTMLAGYTPFANGPNDTPEE 632
Query: 540 AQI---NKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRL 593
+ N + D ISD K L+ ML + R I+ WI +L
Sbjct: 633 ILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSWITHRDQL 689
>AF184965-1|AAF13190.1| 745|Homo sapiens ribosomal S6 kinase
protein.
Length = 745
Score = 136 bits (328), Expect = 3e-31
Identities = 77/259 (29%), Positives = 143/259 (55%), Gaps = 10/259 (3%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
++L K +G+G++ KV+L + D+ + A K+++ A V+ E D+LV +
Sbjct: 73 FELLKVLGQGSFGKVFLVRKKTGPDAGQ-LYAMKVLKKASLKVRDRVR-TKMERDILVEV 130
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP ++ +H FQ + K Y+ + + GD+ + + K +E + + +LAL L +LH
Sbjct: 131 NHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLH 190
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
+L I +RD+K EN+LL ++KL+DFG S+ ES +Q + ++CG++ Y APE++
Sbjct: 191 QLGIVYRDLKPENILLDEIGHIKLTDFGLSK---ESVDQEKKAYSFCGTVEYMAPEVVNR 247
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ + + D WS GV++F ML ++PF K + M + + + LS E ++
Sbjct: 248 RGH-SQSADWWSYGVLMFEMLTGTLPFQG----KDRNETMNMILKAKLGMPQFLSAEAQS 302
Query: 259 VVKHLLEPDPGLRHSATNV 277
+++ L + +P R + V
Sbjct: 303 LLRMLFKRNPANRLGSEGV 321
Score = 116 bits (279), Expect = 3e-25
Identities = 73/257 (28%), Positives = 138/257 (53%), Gaps = 13/257 (5%)
Query: 321 QGDILEGPTRESAFRVYLAEYRNASKNDKLSILACKVID-TSTAPRDFVKKFLPREIEML 379
Q ++L+ + S +V+L R + D + A KV+ S RD V+ + R+I L
Sbjct: 72 QFELLKVLGQGSFGKVFLV--RKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDI--L 127
Query: 380 IKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQ 439
++++HP +V H FQ K ++ + ++ GD+ + + E+ + + +LALA+
Sbjct: 128 VEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALD 187
Query: 440 YMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEI 499
++H+L I +RD+K EN+LL ++KL+DFG ++ VD+ E ++ +FCG++ Y APE+
Sbjct: 188 HLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQ---EKKAYSFCGTVEYMAPEV 244
Query: 500 LQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDN 559
+ + + D WS G++++ ML +PF+ K +N K + +S
Sbjct: 245 VNRRGH-SQSADWWSYGVLMFEMLTGTLPFQGKD----RNETMNMILKAKLGMPQFLSAE 299
Query: 560 CKRLIGLMLEPNHQNRL 576
+ L+ ++ + N NRL
Sbjct: 300 AQSLLRMLFKRNPANRL 316
Score = 99.1 bits (236), Expect = 4e-20
Identities = 78/269 (28%), Positives = 128/269 (47%), Gaps = 22/269 (8%)
Query: 38 YSSKEDSHKSTLA-CKIIETAKAPKDFVVKFLPR-------EIDVLVRLN-HPHLIHVHS 88
Y KED + + CK A +F VK + + EI++L+R HP++I +
Sbjct: 426 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNIITLKD 485
Query: 89 IFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLHELEIAHRDIK 148
+F Y+ + G+LL ILK C SE +A ++ + YLH + HRD+K
Sbjct: 486 VFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLK 545
Query: 149 CENVLL----TANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRGKPYCPK 204
N+L + ++++ DFGF++ + +N +L T C + ++ APE+L + Y
Sbjct: 546 PSNILYMDESASADSIRICDFGFAK-QLRGENGLLL--TPCYTANFVAPEVLMQQGY-DA 601
Query: 205 PTDLWSLGVVLFVMLNKSMPF----DDTRMRKLYEQQMGKKYRFRSRVASILSLECKTVV 260
D+WSLGV+ + ML PF +DT L G K+ +S K ++
Sbjct: 602 ACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNG-KFSLSGGNWDNISDGAKDLL 660
Query: 261 KHLLEPDPGLRHSATNVLDSEWIAMDSRL 289
H+L DP R++A +L WI +L
Sbjct: 661 SHMLHMDPHQRYTAEQILKHSWITHRDQL 689
Score = 83.8 bits (198), Expect = 2e-15
Identities = 64/237 (27%), Positives = 110/237 (46%), Gaps = 14/237 (5%)
Query: 366 DFVKKFLPREIEMLIKLS-HPHLVHTHSIFQR-RYKYFIFMRYMERGDLLEFVLQRGAVQ 423
D K+ EIE+L++ HP+++ +F RY Y + M+ G+LL+ +L++
Sbjct: 458 DKSKRDPSEEIEILMRYGQHPNIITLKDVFDDGRYVYLV-TDLMKGGELLDRILKQKCFS 516
Query: 424 EDQARIWTRQLALAIQYMHELEIAHRDIKCENVLL----TANQNVKLSDFGFARMCVDKK 479
E +A ++ + Y+H + HRD+K N+L + ++++ DFGFA+ +
Sbjct: 517 EREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQL--RG 574
Query: 480 LNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQ 539
N + T C + ++ APE+L Y D+WSLG++ Y ML PF + +
Sbjct: 575 ENGLLL-TPCYTANFVAPEVLMQQGY-DAACDIWSLGVLFYTMLAGYTPFANGPNDTPEE 632
Query: 540 AQI---NKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRL 593
+ N + D ISD K L+ ML + R I+ WI +L
Sbjct: 633 ILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSWITHRDQL 689
>AJ785968-1|CAH05056.1| 396|Homo sapiens PDPK2 protein protein.
Length = 396
Score = 135 bits (327), Expect = 4e-31
Identities = 72/237 (30%), Positives = 130/237 (54%), Gaps = 6/237 (2%)
Query: 8 PSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKF 67
P + + +K K +GEG+++ V L ++E + A KI+E K+ V +
Sbjct: 44 PPQPRKKRPEDFKFGKILGEGSFSTVVL----ARELATSREYAIKILEKRHIIKENKVPY 99
Query: 68 LPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWT 127
+ RE DV+ RL+HP + ++ FQ K Y + Y +NG+LL YI K G E R +T
Sbjct: 100 VTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYT 159
Query: 128 RQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGS 187
++ L+YLH I HRD+K EN+LL + ++++DFG ++ + +++ + ++ G+
Sbjct: 160 AEIVSALEYLHGKGIIHRDLKPENILLNEDMYIQITDFGTAK-VLSPESKQARANSFVGT 218
Query: 188 MSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRF 244
Y +PE+L K C K +DLW+LG +++ ++ PF ++++ + +Y F
Sbjct: 219 AQYVSPELLTEKSAC-KSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDF 274
Score = 111 bits (267), Expect = 7e-24
Identities = 56/213 (26%), Positives = 115/213 (53%), Gaps = 2/213 (0%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLL 413
A K+++ ++ ++ RE +++ +L HP V + FQ K + + Y + G+LL
Sbjct: 82 AIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELL 141
Query: 414 EFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFAR 473
+++ + G+ E R +T ++ A++Y+H I HRD+K EN+LL + ++++DFG A+
Sbjct: 142 KYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMYIQITDFGTAK 201
Query: 474 MCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKH 533
+ + + + R+ +F G+ Y +PE+L K +D+W+LG ++Y ++ PF +
Sbjct: 202 V-LSPESKQARANSFVGTAQYVSPELLTEKSAC-KSSDLWALGCIIYQLVAGLPPFRAGN 259
Query: 534 IKQLHQAQINKNWKFRSRYIDTISDNCKRLIGL 566
+ Q I + F ++ D ++L+ L
Sbjct: 260 EYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVL 292
>AC005581-1|AAC33487.1| 462|Homo sapiens R31237_1, partial CDS
protein.
Length = 462
Score = 135 bits (327), Expect = 4e-31
Identities = 65/179 (36%), Positives = 109/179 (60%), Gaps = 10/179 (5%)
Query: 106 GDLLSYILKNGCVSENQARVWTRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDF 165
G++ Y++ +G + E +AR RQ+ + Y H+ I HRD+K EN+LL A N+K++DF
Sbjct: 171 GEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADF 230
Query: 166 GFSR-FCVESDNQPVLSETYCGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMP 224
GFS F + S +T+CGS YAAPE+ +GK Y D+WSLGV+L+ +++ S+P
Sbjct: 231 GFSNEFTLGSK-----LDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLP 285
Query: 225 FDDTRMRKLYEQQMGKKYRFRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
FD +++L E+ + KY RV +S +C+++++ L +P R + ++ +WI
Sbjct: 286 FDGHNLKELRERVLRGKY----RVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWI 340
Score = 124 bits (300), Expect = 8e-28
Identities = 60/179 (33%), Positives = 106/179 (59%), Gaps = 10/179 (5%)
Query: 410 GDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDF 469
G++ ++++ G ++E +AR RQ+ A+ Y H+ I HRD+K EN+LL A N+K++DF
Sbjct: 171 GEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADF 230
Query: 470 GFA-RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMP 528
GF+ + KL +TFCGS Y APE+ QG Y D+WSLG+++Y +++ ++P
Sbjct: 231 GFSNEFTLGSKL-----DTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLP 285
Query: 529 FEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
F+ ++K+L + + K+R + +S +C+ ++ L N R + I+ +WI
Sbjct: 286 FDGHNLKELRERVL--RGKYRVPFY--MSTDCESILRRFLVLNPAKRCTLEQIMKDKWI 340
Score = 42.7 bits (96), Expect = 0.004
Identities = 23/89 (25%), Positives = 45/89 (50%), Gaps = 5/89 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y+L + +G+G +AKV L + +A KII+ + + K RE+ ++ L
Sbjct: 59 YRLLRTIGKGNFAKVKLARHILTGRE----VAIKIIDKTQLNPSSLQKLF-REVRIMKGL 113
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGD 107
NHP+++ + + + + Y+ M Y G+
Sbjct: 114 NHPNIVKLFEVIETEKTLYLVMEYASAGE 142
Score = 32.3 bits (70), Expect = 5.6
Identities = 17/60 (28%), Positives = 30/60 (50%), Gaps = 3/60 (5%)
Query: 353 LACKVID-TSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
+A K+ID T P K F RE+ ++ L+HP++V + + ++ M Y G+
Sbjct: 85 VAIKIIDKTQLNPSSLQKLF--REVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGE 142
>Z98049-1|CAI20579.1| 733|Homo sapiens ribosomal protein S6 kinase,
90kDa, polypeptide 2 protein.
Length = 733
Score = 135 bits (326), Expect = 5e-31
Identities = 75/251 (29%), Positives = 140/251 (55%), Gaps = 12/251 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAP-KDFVVKFLPREIDVLVR 77
++L K +G+G+Y KV+L D+ + A K+++ A +D V + R D+L
Sbjct: 59 FELLKVLGQGSYGKVFLVRKVKGSDAGQ-LYAMKVLKKATLKVRDRVRSKMER--DILAE 115
Query: 78 LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYL 137
+NHP ++ +H FQ + K Y+ + + GDL + + K +E + + +LAL L +L
Sbjct: 116 VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHL 175
Query: 138 HELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILR 197
H L I +RD+K EN+LL ++K++DFG S+ ++ D + + ++CG++ Y APE++
Sbjct: 176 HSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKR---AYSFCGTIEYMAPEVVN 232
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECK 257
+ + + D WS GV++F ML S+PF K ++ M + + + LS E +
Sbjct: 233 RRGH-TQSADWWSFGVLMFEMLTGSLPFQG----KDRKETMALILKAKLGMPQFLSGEAQ 287
Query: 258 TVVKHLLEPDP 268
++++ L + +P
Sbjct: 288 SLLRALFKRNP 298
Score = 119 bits (287), Expect = 3e-26
Identities = 68/251 (27%), Positives = 138/251 (54%), Gaps = 9/251 (3%)
Query: 287 SRLTTLNAVEAAALKRAKEDRRKLSDVHKHPPKRQGDILEGPTRESAFRVYLAEYRNASK 346
S+ ++L+ +E + + + + + + Q ++L+ + S +V+L R
Sbjct: 24 SKSSSLSRLEEEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLV--RKVKG 81
Query: 347 NDKLSILACKVIDTSTAP-RDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMR 405
+D + A KV+ +T RD V+ + R+I L +++HP +V H FQ K ++ +
Sbjct: 82 SDAGQLYAMKVLKKATLKVRDRVRSKMERDI--LAEVNHPFIVKLHYAFQTEGKLYLILD 139
Query: 406 YMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVK 465
++ GDL + + E+ + + +LALA+ ++H L I +RD+K EN+LL ++K
Sbjct: 140 FLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIK 199
Query: 466 LSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNR 525
++DFG ++ +D ++ R+ +FCG++ Y APE++ + + D WS G++++ ML
Sbjct: 200 ITDFGLSKEAID---HDKRAYSFCGTIEYMAPEVVNRRGH-TQSADWWSFGVLMFEMLTG 255
Query: 526 AMPFEDKHIKQ 536
++PF+ K K+
Sbjct: 256 SLPFQGKDRKE 266
Score = 100 bits (239), Expect = 2e-20
Identities = 79/281 (28%), Positives = 130/281 (46%), Gaps = 25/281 (8%)
Query: 12 NTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPRE 71
N T GY++ + +G G+Y+ + + + + A KII+ +K E
Sbjct: 408 NIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEY----AVKIIDKSKRDPS-------EE 456
Query: 72 IDVLVRLN-HPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQL 130
I++L+R HP++I + ++ Y+ M G+LL IL+ SE +A +
Sbjct: 457 IEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTI 516
Query: 131 ALGLQYLHELEIAHRDIKCENVLLT----ANFNVKLSDFGFSRFCVESDNQPVLSETYCG 186
+ YLH + HRD+K N+L + ++++ DFGF++ + L T C
Sbjct: 517 TKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNG---LLMTPCY 573
Query: 187 SMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPF----DDTRMRKLYEQQMGKKY 242
+ ++ APE+L+ + Y D+WSLG++L+ ML PF DDT L G KY
Sbjct: 574 TANFVAPEVLKRQGY-DAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSG-KY 631
Query: 243 RFRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+S K VV +L DP R +A VL W+
Sbjct: 632 ALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWV 672
Score = 87.4 bits (207), Expect = 1e-16
Identities = 62/242 (25%), Positives = 114/242 (47%), Gaps = 14/242 (5%)
Query: 356 KVIDTSTAPR--DFVKKFLPREIEMLIKLS-HPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
K DT A + D K+ EIE+L++ HP+++ ++ ++ M M G+L
Sbjct: 435 KATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGEL 494
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLT----ANQNVKLSD 468
L+ +L++ E +A + + Y+H + HRD+K N+L + +++++ D
Sbjct: 495 LDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCD 554
Query: 469 FGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMP 528
FGFA+ + T C + ++ APE+L+ Y D+WSLGI++Y ML P
Sbjct: 555 FGFAKQL---RAGNGLLMTPCYTANFVAPEVLKRQGY-DAACDIWSLGILLYTMLAGFTP 610
Query: 529 F---EDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSE 585
F D +++ + + D+ISD K ++ ML + RL ++
Sbjct: 611 FANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHP 670
Query: 586 WI 587
W+
Sbjct: 671 WV 672
>X85106-1|CAA59427.1| 733|Homo sapiens ribosomal S6 kinase protein.
Length = 733
Score = 135 bits (326), Expect = 5e-31
Identities = 75/251 (29%), Positives = 140/251 (55%), Gaps = 12/251 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAP-KDFVVKFLPREIDVLVR 77
++L K +G+G+Y KV+L D+ + A K+++ A +D V + R D+L
Sbjct: 59 FELLKVLGQGSYGKVFLVRKVKGSDAGQ-LYAMKVLKKATLKVRDRVRSKMER--DILAE 115
Query: 78 LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYL 137
+NHP ++ +H FQ + K Y+ + + GDL + + K +E + + +LAL L +L
Sbjct: 116 VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHL 175
Query: 138 HELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILR 197
H L I +RD+K EN+LL ++K++DFG S+ ++ D + + ++CG++ Y APE++
Sbjct: 176 HSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKR---AYSFCGTIEYMAPEVVN 232
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECK 257
+ + + D WS GV++F ML S+PF K ++ M + + + LS E +
Sbjct: 233 RRGH-TQSADWWSFGVLMFEMLTGSLPFQG----KDRKETMALILKAKLGMPQFLSGEAQ 287
Query: 258 TVVKHLLEPDP 268
++++ L + +P
Sbjct: 288 SLLRALFKRNP 298
Score = 119 bits (287), Expect = 3e-26
Identities = 68/251 (27%), Positives = 138/251 (54%), Gaps = 9/251 (3%)
Query: 287 SRLTTLNAVEAAALKRAKEDRRKLSDVHKHPPKRQGDILEGPTRESAFRVYLAEYRNASK 346
S+ ++L+ +E + + + + + + Q ++L+ + S +V+L R
Sbjct: 24 SKSSSLSRLEEEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLV--RKVKG 81
Query: 347 NDKLSILACKVIDTSTAP-RDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMR 405
+D + A KV+ +T RD V+ + R+I L +++HP +V H FQ K ++ +
Sbjct: 82 SDAGQLYAMKVLKKATLKVRDRVRSKMERDI--LAEVNHPFIVKLHYAFQTEGKLYLILD 139
Query: 406 YMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVK 465
++ GDL + + E+ + + +LALA+ ++H L I +RD+K EN+LL ++K
Sbjct: 140 FLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIK 199
Query: 466 LSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNR 525
++DFG ++ +D ++ R+ +FCG++ Y APE++ + + D WS G++++ ML
Sbjct: 200 ITDFGLSKEAID---HDKRAYSFCGTIEYMAPEVVNRRGH-TQSADWWSFGVLMFEMLTG 255
Query: 526 AMPFEDKHIKQ 536
++PF+ K K+
Sbjct: 256 SLPFQGKDRKE 266
Score = 100 bits (239), Expect = 2e-20
Identities = 79/281 (28%), Positives = 130/281 (46%), Gaps = 25/281 (8%)
Query: 12 NTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPRE 71
N T GY++ + +G G+Y+ + + + + A KII+ +K E
Sbjct: 408 NIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEY----AVKIIDKSKRDPS-------EE 456
Query: 72 IDVLVRLN-HPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQL 130
I++L+R HP++I + ++ Y+ M G+LL IL+ SE +A +
Sbjct: 457 IEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTI 516
Query: 131 ALGLQYLHELEIAHRDIKCENVLLT----ANFNVKLSDFGFSRFCVESDNQPVLSETYCG 186
+ YLH + HRD+K N+L + ++++ DFGF++ + L T C
Sbjct: 517 TKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNG---LLMTPCY 573
Query: 187 SMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPF----DDTRMRKLYEQQMGKKY 242
+ ++ APE+L+ + Y D+WSLG++L+ ML PF DDT L G KY
Sbjct: 574 TANFVAPEVLKRQGY-DAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSG-KY 631
Query: 243 RFRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+S K VV +L DP R +A VL W+
Sbjct: 632 ALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWV 672
Score = 87.4 bits (207), Expect = 1e-16
Identities = 62/242 (25%), Positives = 114/242 (47%), Gaps = 14/242 (5%)
Query: 356 KVIDTSTAPR--DFVKKFLPREIEMLIKLS-HPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
K DT A + D K+ EIE+L++ HP+++ ++ ++ M M G+L
Sbjct: 435 KATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGEL 494
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLT----ANQNVKLSD 468
L+ +L++ E +A + + Y+H + HRD+K N+L + +++++ D
Sbjct: 495 LDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCD 554
Query: 469 FGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMP 528
FGFA+ + T C + ++ APE+L+ Y D+WSLGI++Y ML P
Sbjct: 555 FGFAKQL---RAGNGLLMTPCYTANFVAPEVLKRQGY-DAACDIWSLGILLYTMLAGFTP 610
Query: 529 F---EDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSE 585
F D +++ + + D+ISD K ++ ML + RL ++
Sbjct: 611 FANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHP 670
Query: 586 WI 587
W+
Sbjct: 671 WV 672
>L33881-1|AAB17011.1| 587|Homo sapiens protein kinase C iota
protein.
Length = 587
Score = 135 bits (326), Expect = 5e-31
Identities = 82/264 (31%), Positives = 140/264 (53%), Gaps = 16/264 (6%)
Query: 12 NTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPRE 71
++L + + L + +G G+YAKV L + + A K+++ D + ++ E
Sbjct: 238 SSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIY----AMKVVKKELVNDDEDIDWVQTE 293
Query: 72 IDVLVRL-NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQL 130
V + NHP L+ +HS FQ +++ + + Y GDL+ ++ + + E AR ++ ++
Sbjct: 294 KHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEI 353
Query: 131 ALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSY 190
+L L YLHE I +RD+K +NVLL + ++KL+D+G C E + T+CG+ +Y
Sbjct: 354 SLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYG---MCKEGLRPGDTTSTFCGTPNY 410
Query: 191 AAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRF------ 244
APEILRG+ Y D W+LGV++F M+ PFD +Q + Y F
Sbjct: 411 IAPEILRGEDY-GFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNT-EDYLFQVILEK 468
Query: 245 RSRVASILSLECKTVVKHLLEPDP 268
+ R+ LS++ +V+K L DP
Sbjct: 469 QIRIPRSLSVKAASVLKSFLNKDP 492
Score = 111 bits (268), Expect = 6e-24
Identities = 69/209 (33%), Positives = 114/209 (54%), Gaps = 10/209 (4%)
Query: 323 DILEGPTRESAFRVYLAEYRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKL 382
D+L R S +V L + K D+ I A KV+ D ++ E + +
Sbjct: 246 DLLRVIGRGSYAKVLLVRLK---KTDR--IYAMKVVKKELVNDDEDIDWVQTEKHVFEQA 300
Query: 383 S-HPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYM 441
S HP LV HS FQ + F + Y+ GDL+ + ++ + E+ AR ++ +++LA+ Y+
Sbjct: 301 SNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYL 360
Query: 442 HELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQ 501
HE I +RD+K +NVLL + ++KL+D+G MC + + TFCG+ +Y APEIL+
Sbjct: 361 HERGIIYRDLKLDNVLLDSEGHIKLTDYG---MCKEGLRPGDTTSTFCGTPNYIAPEILR 417
Query: 502 GTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
G Y D W+LG++++ M+ PF+
Sbjct: 418 GEDY-GFSVDWWALGVLMFEMMAGRSPFD 445
>L18964-1|AAA60171.1| 587|Homo sapiens protein kinase C iota
protein.
Length = 587
Score = 135 bits (326), Expect = 5e-31
Identities = 82/264 (31%), Positives = 140/264 (53%), Gaps = 16/264 (6%)
Query: 12 NTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPRE 71
++L + + L + +G G+YAKV L + + A K+++ D + ++ E
Sbjct: 238 SSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIY----AMKVVKKELVNDDEDIDWVQTE 293
Query: 72 IDVLVRL-NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQL 130
V + NHP L+ +HS FQ +++ + + Y GDL+ ++ + + E AR ++ ++
Sbjct: 294 KHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEI 353
Query: 131 ALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSY 190
+L L YLHE I +RD+K +NVLL + ++KL+D+G C E + T+CG+ +Y
Sbjct: 354 SLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYG---MCKEGLRPGDTTSTFCGTPNY 410
Query: 191 AAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRF------ 244
APEILRG+ Y D W+LGV++F M+ PFD +Q + Y F
Sbjct: 411 IAPEILRGEDY-GFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNT-EDYLFQVILEK 468
Query: 245 RSRVASILSLECKTVVKHLLEPDP 268
+ R+ LS++ +V+K L DP
Sbjct: 469 QIRIPRSLSVKAASVLKSFLNKDP 492
Score = 111 bits (268), Expect = 6e-24
Identities = 69/209 (33%), Positives = 114/209 (54%), Gaps = 10/209 (4%)
Query: 323 DILEGPTRESAFRVYLAEYRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKL 382
D+L R S +V L + K D+ I A KV+ D ++ E + +
Sbjct: 246 DLLRVIGRGSYAKVLLVRLK---KTDR--IYAMKVVKKELVNDDEDIDWVQTEKHVFEQA 300
Query: 383 S-HPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYM 441
S HP LV HS FQ + F + Y+ GDL+ + ++ + E+ AR ++ +++LA+ Y+
Sbjct: 301 SNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYL 360
Query: 442 HELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQ 501
HE I +RD+K +NVLL + ++KL+D+G MC + + TFCG+ +Y APEIL+
Sbjct: 361 HERGIIYRDLKLDNVLLDSEGHIKLTDYG---MCKEGLRPGDTTSTFCGTPNYIAPEILR 417
Query: 502 GTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
G Y D W+LG++++ M+ PF+
Sbjct: 418 GEDY-GFSVDWWALGVLMFEMMAGRSPFD 445
>L07597-1|AAC82497.1| 735|Homo sapiens ribosomal protein S6 kinase
1 protein.
Length = 735
Score = 135 bits (326), Expect = 5e-31
Identities = 76/253 (30%), Positives = 140/253 (55%), Gaps = 10/253 (3%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
++L K +G+G++ KV+L ++ DS A K+++ A V+ E D+L +
Sbjct: 62 FELLKVLGQGSFGKVFLVRKVTRPDSGH-LYAMKVLKKATLKVRDRVR-TKMERDILADV 119
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP ++ +H FQ + K Y+ + + GDL + + K +E + + +LALGL +LH
Sbjct: 120 NHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLH 179
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
L I +RD+K EN+LL ++KL+DFG S+ ++ + + + ++CG++ Y APE++
Sbjct: 180 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKK---AYSFCGTVEYMAPEVVNR 236
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ + D WS GV++F ML S+PF K ++ M + + + LS E ++
Sbjct: 237 QGH-SHSADWWSYGVLMFEMLTGSLPFQG----KDRKETMTLILKAKLGMPQFLSTEAQS 291
Query: 259 VVKHLLEPDPGLR 271
+++ L + +P R
Sbjct: 292 LLRALFKRNPANR 304
Score = 114 bits (275), Expect = 8e-25
Identities = 60/196 (30%), Positives = 111/196 (56%), Gaps = 7/196 (3%)
Query: 342 RNASKNDKLSILACKVIDTSTAP-RDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKY 400
R ++ D + A KV+ +T RD V+ + R+I L ++HP +V H FQ K
Sbjct: 80 RKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDI--LADVNHPFVVKLHYAFQTEGKL 137
Query: 401 FIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTA 460
++ + ++ GDL + + E+ + + +LAL + ++H L I +RD+K EN+LL
Sbjct: 138 YLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDE 197
Query: 461 NQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVY 520
++KL+DFG ++ +D +E ++ +FCG++ Y APE++ + D WS G++++
Sbjct: 198 EGHIKLTDFGLSKEAID---HEKKAYSFCGTVEYMAPEVVNRQGH-SHSADWWSYGVLMF 253
Query: 521 VMLNRAMPFEDKHIKQ 536
ML ++PF+ K K+
Sbjct: 254 EMLTGSLPFQGKDRKE 269
Score = 99 bits (238), Expect = 2e-20
Identities = 79/291 (27%), Positives = 137/291 (47%), Gaps = 31/291 (10%)
Query: 11 ENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKST---LACKIIETAKAPKDFVVKF 67
+N + + GY + + +G G+Y++ K HK+T A K+I+ +K
Sbjct: 410 KNLVFSDGYVVKETIGVGSYSEC-------KRCVHKATNMEYAVKVIDKSKRDPS----- 457
Query: 68 LPREIDVLVRLN-HPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVW 126
EI++L+R HP++I + ++ Y+ G+LL IL+ SE +A
Sbjct: 458 --EEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFV 515
Query: 127 TRQLALGLQYLHELEIAHRDIKCENVLLTANFN----VKLSDFGFSRFCVESDNQPVLSE 182
+ ++YLH + HRD+K N+L +++ DFGF++ + ++N L
Sbjct: 516 LHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAK-QLRAENG--LLM 572
Query: 183 TYCGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPF----DDTRMRKLYEQQM 238
T C + ++ APE+L+ + Y + D+WSLG++L+ ML PF DT L
Sbjct: 573 TPCYTANFVAPEVLKRQGY-DEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGS 631
Query: 239 GKKYRFRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRL 289
G K+ + +S K +V +L DP R +A VL W+ +L
Sbjct: 632 G-KFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKL 681
Score = 89.0 bits (211), Expect = 5e-17
Identities = 70/273 (25%), Positives = 126/273 (46%), Gaps = 25/273 (9%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIKLS-HPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
A KVID S K+ EIE+L++ HP+++ ++ ++ M G+L
Sbjct: 445 AVKVIDKS-------KRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGEL 497
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQN----VKLSD 468
L+ +L++ E +A + ++Y+H + HRD+K N+L +++ D
Sbjct: 498 LDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICD 557
Query: 469 FGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMP 528
FGFA+ + N + T C + ++ APE+L+ Y + D+WSLGI++Y ML P
Sbjct: 558 FGFAKQL--RAENGLLM-TPCYTANFVAPEVLKRQGY-DEGCDIWSLGILLYTMLAGYTP 613
Query: 529 F----EDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNS 584
F D + L + K + +T+S+ K L+ ML + RL ++
Sbjct: 614 FANGPSDTPEEILTRIGSGK-FTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQH 672
Query: 585 EWIAMDSRLLEWTPQETLAYKKAREEKNKLHKT 617
W+ +L PQ L+++ + K + T
Sbjct: 673 PWVTQKDKL----PQSQLSHQDLQLVKGAMAAT 701
>BC014966-1|AAH14966.1| 735|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 1 protein.
Length = 735
Score = 135 bits (326), Expect = 5e-31
Identities = 76/253 (30%), Positives = 140/253 (55%), Gaps = 10/253 (3%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
++L K +G+G++ KV+L ++ DS A K+++ A V+ E D+L +
Sbjct: 62 FELLKVLGQGSFGKVFLVRKVTRPDSGH-LYAMKVLKKATLKVRDRVR-TKMERDILADV 119
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP ++ +H FQ + K Y+ + + GDL + + K +E + + +LALGL +LH
Sbjct: 120 NHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLH 179
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
L I +RD+K EN+LL ++KL+DFG S+ ++ + + + ++CG++ Y APE++
Sbjct: 180 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKK---AYSFCGTVEYMAPEVVNR 236
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ + D WS GV++F ML S+PF K ++ M + + + LS E ++
Sbjct: 237 QGH-SHSADWWSYGVLMFEMLTGSLPFQG----KDRKETMTLILKAKLGMPQFLSTEAQS 291
Query: 259 VVKHLLEPDPGLR 271
+++ L + +P R
Sbjct: 292 LLRALFKRNPANR 304
Score = 114 bits (275), Expect = 8e-25
Identities = 60/196 (30%), Positives = 111/196 (56%), Gaps = 7/196 (3%)
Query: 342 RNASKNDKLSILACKVIDTSTAP-RDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKY 400
R ++ D + A KV+ +T RD V+ + R+I L ++HP +V H FQ K
Sbjct: 80 RKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDI--LADVNHPFVVKLHYAFQTEGKL 137
Query: 401 FIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTA 460
++ + ++ GDL + + E+ + + +LAL + ++H L I +RD+K EN+LL
Sbjct: 138 YLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDE 197
Query: 461 NQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVY 520
++KL+DFG ++ +D +E ++ +FCG++ Y APE++ + D WS G++++
Sbjct: 198 EGHIKLTDFGLSKEAID---HEKKAYSFCGTVEYMAPEVVNRQGH-SHSADWWSYGVLMF 253
Query: 521 VMLNRAMPFEDKHIKQ 536
ML ++PF+ K K+
Sbjct: 254 EMLTGSLPFQGKDRKE 269
Score = 99 bits (238), Expect = 2e-20
Identities = 79/291 (27%), Positives = 137/291 (47%), Gaps = 31/291 (10%)
Query: 11 ENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKST---LACKIIETAKAPKDFVVKF 67
+N + + GY + + +G G+Y++ K HK+T A K+I+ +K
Sbjct: 410 KNLVFSDGYVVKETIGVGSYSEC-------KRCVHKATNMEYAVKVIDKSKRDPS----- 457
Query: 68 LPREIDVLVRLN-HPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVW 126
EI++L+R HP++I + ++ Y+ G+LL IL+ SE +A
Sbjct: 458 --EEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFV 515
Query: 127 TRQLALGLQYLHELEIAHRDIKCENVLLTANFN----VKLSDFGFSRFCVESDNQPVLSE 182
+ ++YLH + HRD+K N+L +++ DFGF++ + ++N L
Sbjct: 516 LHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAK-QLRAENG--LLM 572
Query: 183 TYCGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPF----DDTRMRKLYEQQM 238
T C + ++ APE+L+ + Y + D+WSLG++L+ ML PF DT L
Sbjct: 573 TPCYTANFVAPEVLKRQGY-DEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGS 631
Query: 239 GKKYRFRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRL 289
G K+ + +S K +V +L DP R +A VL W+ +L
Sbjct: 632 G-KFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKL 681
Score = 89.0 bits (211), Expect = 5e-17
Identities = 70/273 (25%), Positives = 126/273 (46%), Gaps = 25/273 (9%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIKLS-HPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
A KVID S K+ EIE+L++ HP+++ ++ ++ M G+L
Sbjct: 445 AVKVIDKS-------KRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGEL 497
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQN----VKLSD 468
L+ +L++ E +A + ++Y+H + HRD+K N+L +++ D
Sbjct: 498 LDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICD 557
Query: 469 FGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMP 528
FGFA+ + N + T C + ++ APE+L+ Y + D+WSLGI++Y ML P
Sbjct: 558 FGFAKQL--RAENGLLM-TPCYTANFVAPEVLKRQGY-DEGCDIWSLGILLYTMLAGYTP 613
Query: 529 F----EDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNS 584
F D + L + K + +T+S+ K L+ ML + RL ++
Sbjct: 614 FANGPSDTPEEILTRIGSGK-FTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQH 672
Query: 585 EWIAMDSRLLEWTPQETLAYKKAREEKNKLHKT 617
W+ +L PQ L+++ + K + T
Sbjct: 673 PWVTQKDKL----PQSQLSHQDLQLVKGAMAAT 701
>BC002363-1|AAH02363.1| 733|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 2 protein.
Length = 733
Score = 135 bits (326), Expect = 5e-31
Identities = 75/251 (29%), Positives = 140/251 (55%), Gaps = 12/251 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAP-KDFVVKFLPREIDVLVR 77
++L K +G+G+Y KV+L D+ + A K+++ A +D V + R D+L
Sbjct: 59 FELLKVLGQGSYGKVFLVRKVKGSDAGQ-LYAMKVLKKATLKVRDRVRSKMER--DILAE 115
Query: 78 LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYL 137
+NHP ++ +H FQ + K Y+ + + GDL + + K +E + + +LAL L +L
Sbjct: 116 VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHL 175
Query: 138 HELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILR 197
H L I +RD+K EN+LL ++K++DFG S+ ++ D + + ++CG++ Y APE++
Sbjct: 176 HSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKR---AYSFCGTIEYMAPEVVN 232
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECK 257
+ + + D WS GV++F ML S+PF K ++ M + + + LS E +
Sbjct: 233 RRGH-TQSADWWSFGVLMFEMLTGSLPFQG----KDRKETMALILKAKLGMPQFLSGEAQ 287
Query: 258 TVVKHLLEPDP 268
++++ L + +P
Sbjct: 288 SLLRALFKRNP 298
Score = 119 bits (287), Expect = 3e-26
Identities = 68/251 (27%), Positives = 138/251 (54%), Gaps = 9/251 (3%)
Query: 287 SRLTTLNAVEAAALKRAKEDRRKLSDVHKHPPKRQGDILEGPTRESAFRVYLAEYRNASK 346
S+ ++L+ +E + + + + + + Q ++L+ + S +V+L R
Sbjct: 24 SKSSSLSRLEEEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLV--RKVKG 81
Query: 347 NDKLSILACKVIDTSTAP-RDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMR 405
+D + A KV+ +T RD V+ + R+I L +++HP +V H FQ K ++ +
Sbjct: 82 SDAGQLYAMKVLKKATLKVRDRVRSKMERDI--LAEVNHPFIVKLHYAFQTEGKLYLILD 139
Query: 406 YMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVK 465
++ GDL + + E+ + + +LALA+ ++H L I +RD+K EN+LL ++K
Sbjct: 140 FLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIK 199
Query: 466 LSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNR 525
++DFG ++ +D ++ R+ +FCG++ Y APE++ + + D WS G++++ ML
Sbjct: 200 ITDFGLSKEAID---HDKRAYSFCGTIEYMAPEVVNRRGH-TQSADWWSFGVLMFEMLTG 255
Query: 526 AMPFEDKHIKQ 536
++PF+ K K+
Sbjct: 256 SLPFQGKDRKE 266
Score = 100 bits (239), Expect = 2e-20
Identities = 79/281 (28%), Positives = 130/281 (46%), Gaps = 25/281 (8%)
Query: 12 NTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPRE 71
N T GY++ + +G G+Y+ + + + + A KII+ +K E
Sbjct: 408 NIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEY----AVKIIDKSKRDPS-------EE 456
Query: 72 IDVLVRLN-HPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQL 130
I++L+R HP++I + ++ Y+ M G+LL IL+ SE +A +
Sbjct: 457 IEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTI 516
Query: 131 ALGLQYLHELEIAHRDIKCENVLLT----ANFNVKLSDFGFSRFCVESDNQPVLSETYCG 186
+ YLH + HRD+K N+L + ++++ DFGF++ + L T C
Sbjct: 517 TKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNG---LLMTPCY 573
Query: 187 SMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPF----DDTRMRKLYEQQMGKKY 242
+ ++ APE+L+ + Y D+WSLG++L+ ML PF DDT L G KY
Sbjct: 574 TANFVAPEVLKRQGY-DAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSG-KY 631
Query: 243 RFRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+S K VV +L DP R +A VL W+
Sbjct: 632 ALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWV 672
Score = 87.4 bits (207), Expect = 1e-16
Identities = 62/242 (25%), Positives = 114/242 (47%), Gaps = 14/242 (5%)
Query: 356 KVIDTSTAPR--DFVKKFLPREIEMLIKLS-HPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
K DT A + D K+ EIE+L++ HP+++ ++ ++ M M G+L
Sbjct: 435 KATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGEL 494
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLT----ANQNVKLSD 468
L+ +L++ E +A + + Y+H + HRD+K N+L + +++++ D
Sbjct: 495 LDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCD 554
Query: 469 FGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMP 528
FGFA+ + T C + ++ APE+L+ Y D+WSLGI++Y ML P
Sbjct: 555 FGFAKQL---RAGNGLLMTPCYTANFVAPEVLKRQGY-DAACDIWSLGILLYTMLAGFTP 610
Query: 529 F---EDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSE 585
F D +++ + + D+ISD K ++ ML + RL ++
Sbjct: 611 FANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHP 670
Query: 586 WI 587
W+
Sbjct: 671 WV 672
>AL627313-6|CAI14649.1| 735|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 1 protein.
Length = 735
Score = 135 bits (326), Expect = 5e-31
Identities = 76/253 (30%), Positives = 140/253 (55%), Gaps = 10/253 (3%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
++L K +G+G++ KV+L ++ DS A K+++ A V+ E D+L +
Sbjct: 62 FELLKVLGQGSFGKVFLVRKVTRPDSGH-LYAMKVLKKATLKVRDRVR-TKMERDILADV 119
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP ++ +H FQ + K Y+ + + GDL + + K +E + + +LALGL +LH
Sbjct: 120 NHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLH 179
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
L I +RD+K EN+LL ++KL+DFG S+ ++ + + + ++CG++ Y APE++
Sbjct: 180 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKK---AYSFCGTVEYMAPEVVNR 236
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ + D WS GV++F ML S+PF K ++ M + + + LS E ++
Sbjct: 237 QGH-SHSADWWSYGVLMFEMLTGSLPFQG----KDRKETMTLILKAKLGMPQFLSTEAQS 291
Query: 259 VVKHLLEPDPGLR 271
+++ L + +P R
Sbjct: 292 LLRALFKRNPANR 304
Score = 114 bits (275), Expect = 8e-25
Identities = 60/196 (30%), Positives = 111/196 (56%), Gaps = 7/196 (3%)
Query: 342 RNASKNDKLSILACKVIDTSTAP-RDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKY 400
R ++ D + A KV+ +T RD V+ + R+I L ++HP +V H FQ K
Sbjct: 80 RKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDI--LADVNHPFVVKLHYAFQTEGKL 137
Query: 401 FIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTA 460
++ + ++ GDL + + E+ + + +LAL + ++H L I +RD+K EN+LL
Sbjct: 138 YLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDE 197
Query: 461 NQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVY 520
++KL+DFG ++ +D +E ++ +FCG++ Y APE++ + D WS G++++
Sbjct: 198 EGHIKLTDFGLSKEAID---HEKKAYSFCGTVEYMAPEVVNRQGH-SHSADWWSYGVLMF 253
Query: 521 VMLNRAMPFEDKHIKQ 536
ML ++PF+ K K+
Sbjct: 254 EMLTGSLPFQGKDRKE 269
Score = 99 bits (238), Expect = 2e-20
Identities = 79/291 (27%), Positives = 137/291 (47%), Gaps = 31/291 (10%)
Query: 11 ENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKST---LACKIIETAKAPKDFVVKF 67
+N + + GY + + +G G+Y++ K HK+T A K+I+ +K
Sbjct: 410 KNLVFSDGYVVKETIGVGSYSEC-------KRCVHKATNMEYAVKVIDKSKRDPS----- 457
Query: 68 LPREIDVLVRLN-HPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVW 126
EI++L+R HP++I + ++ Y+ G+LL IL+ SE +A
Sbjct: 458 --EEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFV 515
Query: 127 TRQLALGLQYLHELEIAHRDIKCENVLLTANFN----VKLSDFGFSRFCVESDNQPVLSE 182
+ ++YLH + HRD+K N+L +++ DFGF++ + ++N L
Sbjct: 516 LHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAK-QLRAENG--LLM 572
Query: 183 TYCGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPF----DDTRMRKLYEQQM 238
T C + ++ APE+L+ + Y + D+WSLG++L+ ML PF DT L
Sbjct: 573 TPCYTANFVAPEVLKRQGY-DEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGS 631
Query: 239 GKKYRFRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRL 289
G K+ + +S K +V +L DP R +A VL W+ +L
Sbjct: 632 G-KFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKL 681
Score = 89.0 bits (211), Expect = 5e-17
Identities = 70/273 (25%), Positives = 126/273 (46%), Gaps = 25/273 (9%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIKLS-HPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
A KVID S K+ EIE+L++ HP+++ ++ ++ M G+L
Sbjct: 445 AVKVIDKS-------KRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGEL 497
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQN----VKLSD 468
L+ +L++ E +A + ++Y+H + HRD+K N+L +++ D
Sbjct: 498 LDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICD 557
Query: 469 FGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMP 528
FGFA+ + N + T C + ++ APE+L+ Y + D+WSLGI++Y ML P
Sbjct: 558 FGFAKQL--RAENGLLM-TPCYTANFVAPEVLKRQGY-DEGCDIWSLGILLYTMLAGYTP 613
Query: 529 F----EDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNS 584
F D + L + K + +T+S+ K L+ ML + RL ++
Sbjct: 614 FANGPSDTPEEILTRIGSGK-FTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQH 672
Query: 585 EWIAMDSRLLEWTPQETLAYKKAREEKNKLHKT 617
W+ +L PQ L+++ + K + T
Sbjct: 673 PWVTQKDKL----PQSQLSHQDLQLVKGAMAAT 701
>AL022069-2|CAI19651.1| 733|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 2 protein.
Length = 733
Score = 135 bits (326), Expect = 5e-31
Identities = 75/251 (29%), Positives = 140/251 (55%), Gaps = 12/251 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAP-KDFVVKFLPREIDVLVR 77
++L K +G+G+Y KV+L D+ + A K+++ A +D V + R D+L
Sbjct: 59 FELLKVLGQGSYGKVFLVRKVKGSDAGQ-LYAMKVLKKATLKVRDRVRSKMER--DILAE 115
Query: 78 LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYL 137
+NHP ++ +H FQ + K Y+ + + GDL + + K +E + + +LAL L +L
Sbjct: 116 VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHL 175
Query: 138 HELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILR 197
H L I +RD+K EN+LL ++K++DFG S+ ++ D + + ++CG++ Y APE++
Sbjct: 176 HSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKR---AYSFCGTIEYMAPEVVN 232
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECK 257
+ + + D WS GV++F ML S+PF K ++ M + + + LS E +
Sbjct: 233 RRGH-TQSADWWSFGVLMFEMLTGSLPFQG----KDRKETMALILKAKLGMPQFLSGEAQ 287
Query: 258 TVVKHLLEPDP 268
++++ L + +P
Sbjct: 288 SLLRALFKRNP 298
Score = 119 bits (287), Expect = 3e-26
Identities = 68/251 (27%), Positives = 138/251 (54%), Gaps = 9/251 (3%)
Query: 287 SRLTTLNAVEAAALKRAKEDRRKLSDVHKHPPKRQGDILEGPTRESAFRVYLAEYRNASK 346
S+ ++L+ +E + + + + + + Q ++L+ + S +V+L R
Sbjct: 24 SKSSSLSRLEEEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLV--RKVKG 81
Query: 347 NDKLSILACKVIDTSTAP-RDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMR 405
+D + A KV+ +T RD V+ + R+I L +++HP +V H FQ K ++ +
Sbjct: 82 SDAGQLYAMKVLKKATLKVRDRVRSKMERDI--LAEVNHPFIVKLHYAFQTEGKLYLILD 139
Query: 406 YMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVK 465
++ GDL + + E+ + + +LALA+ ++H L I +RD+K EN+LL ++K
Sbjct: 140 FLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIK 199
Query: 466 LSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNR 525
++DFG ++ +D ++ R+ +FCG++ Y APE++ + + D WS G++++ ML
Sbjct: 200 ITDFGLSKEAID---HDKRAYSFCGTIEYMAPEVVNRRGH-TQSADWWSFGVLMFEMLTG 255
Query: 526 AMPFEDKHIKQ 536
++PF+ K K+
Sbjct: 256 SLPFQGKDRKE 266
Score = 100 bits (239), Expect = 2e-20
Identities = 79/281 (28%), Positives = 130/281 (46%), Gaps = 25/281 (8%)
Query: 12 NTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPRE 71
N T GY++ + +G G+Y+ + + + + A KII+ +K E
Sbjct: 408 NIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEY----AVKIIDKSKRDPS-------EE 456
Query: 72 IDVLVRLN-HPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQL 130
I++L+R HP++I + ++ Y+ M G+LL IL+ SE +A +
Sbjct: 457 IEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTI 516
Query: 131 ALGLQYLHELEIAHRDIKCENVLLT----ANFNVKLSDFGFSRFCVESDNQPVLSETYCG 186
+ YLH + HRD+K N+L + ++++ DFGF++ + L T C
Sbjct: 517 TKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNG---LLMTPCY 573
Query: 187 SMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPF----DDTRMRKLYEQQMGKKY 242
+ ++ APE+L+ + Y D+WSLG++L+ ML PF DDT L G KY
Sbjct: 574 TANFVAPEVLKRQGY-DAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSG-KY 631
Query: 243 RFRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+S K VV +L DP R +A VL W+
Sbjct: 632 ALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWV 672
Score = 87.4 bits (207), Expect = 1e-16
Identities = 62/242 (25%), Positives = 114/242 (47%), Gaps = 14/242 (5%)
Query: 356 KVIDTSTAPR--DFVKKFLPREIEMLIKLS-HPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
K DT A + D K+ EIE+L++ HP+++ ++ ++ M M G+L
Sbjct: 435 KATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGEL 494
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLT----ANQNVKLSD 468
L+ +L++ E +A + + Y+H + HRD+K N+L + +++++ D
Sbjct: 495 LDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCD 554
Query: 469 FGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMP 528
FGFA+ + T C + ++ APE+L+ Y D+WSLGI++Y ML P
Sbjct: 555 FGFAKQL---RAGNGLLMTPCYTANFVAPEVLKRQGY-DAACDIWSLGILLYTMLAGFTP 610
Query: 529 F---EDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSE 585
F D +++ + + D+ISD K ++ ML + RL ++
Sbjct: 611 FANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHP 670
Query: 586 WI 587
W+
Sbjct: 671 WV 672
>AF226044-1|AAF86944.1| 765|Homo sapiens HSNFRK protein.
Length = 765
Score = 135 bits (326), Expect = 5e-31
Identities = 87/292 (29%), Positives = 146/292 (50%), Gaps = 18/292 (6%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y L K +G G +A V L + + +A K+I+ K L +E+ + +
Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEK----VAVKVIDKTKLDT-LATGHLFQEVRCMKLV 70
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNG-CVSENQARVWTRQLALGLQYL 137
HP+++ ++ + +TK Y+ + + GD+ YI+K+ ++E+ + + Q+ + Y
Sbjct: 71 QHPNIVRLYEVIDTQTKLYLILELGDEGDMFDYIMKHEEGLNEDLPKKYFAQIVHAISYC 130
Query: 138 HELEIAHRDIKCENVLLTANFN-VKLSDFGFSRFCVESDNQPVLS-ETYCGSMSYAAPEI 195
H+L + HRD+K ENV+ VKL+DFGFS + QP T CGS++Y+APEI
Sbjct: 131 HKLHVVHRDLKPENVVFFEKQGLVKLTDFGFS-----NKFQPGKKLTTSCGSLAYSAPEI 185
Query: 196 LRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLE 255
L G Y D+WSLGV+LF+++ PF + + M KY V S +S E
Sbjct: 186 LLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKY----TVPSHVSKE 241
Query: 256 CKTVVKHLLEPDPGLRHSATNVLDSEWI-AMDSRLTTLNAVEAAALKRAKED 306
CK ++ +L+ DP R S + + W+ +D T + + K E+
Sbjct: 242 CKDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYKNLSEE 293
Score = 123 bits (296), Expect = 2e-27
Identities = 77/264 (29%), Positives = 137/264 (51%), Gaps = 14/264 (5%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A KVID T L +E+ + + HP++V + + + K ++ + + GD+
Sbjct: 42 VAVKVID-KTKLDTLATGHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDEGDM 100
Query: 413 LEFVLQRG-AVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQN-VKLSDFG 470
+++++ + ED + + Q+ AI Y H+L + HRD+K ENV+ Q VKL+DFG
Sbjct: 101 FDYIMKHEEGLNEDLPKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFG 160
Query: 471 FA-RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPF 529
F+ + KKL T CGSL+Y+APEIL G Y D+WSLG+++++++ PF
Sbjct: 161 FSNKFQPGKKLT-----TSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPF 215
Query: 530 EDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI-A 588
++ + + ++ + S +S CK LI ML+ + + R + +I N W+
Sbjct: 216 QEANDSETLTMIMDCKYTVPSH----VSKECKDLITRMLQRDPKRRASLEEIENHPWLQG 271
Query: 589 MDSRLLEWTPQETLAYKKAREEKN 612
+D ++YK EE++
Sbjct: 272 VDPSPATKYNIPLVSYKNLSEEEH 295
>AB209116-1|BAD92353.1| 806|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 2 isoform b variant protein.
Length = 806
Score = 135 bits (326), Expect = 5e-31
Identities = 75/251 (29%), Positives = 140/251 (55%), Gaps = 12/251 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAP-KDFVVKFLPREIDVLVR 77
++L K +G+G+Y KV+L D+ + A K+++ A +D V + R D+L
Sbjct: 132 FELLKVLGQGSYGKVFLVRKVKGSDAGQ-LYAMKVLKKATLKVRDRVRSKMER--DILAE 188
Query: 78 LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYL 137
+NHP ++ +H FQ + K Y+ + + GDL + + K +E + + +LAL L +L
Sbjct: 189 VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHL 248
Query: 138 HELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILR 197
H L I +RD+K EN+LL ++K++DFG S+ ++ D + + ++CG++ Y APE++
Sbjct: 249 HSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKR---AYSFCGTIEYMAPEVVN 305
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECK 257
+ + + D WS GV++F ML S+PF K ++ M + + + LS E +
Sbjct: 306 RRGH-TQSADWWSFGVLMFEMLTGSLPFQG----KDRKETMALILKAKLGMPQFLSGEAQ 360
Query: 258 TVVKHLLEPDP 268
++++ L + +P
Sbjct: 361 SLLRALFKRNP 371
Score = 118 bits (284), Expect = 7e-26
Identities = 65/217 (29%), Positives = 124/217 (57%), Gaps = 9/217 (4%)
Query: 321 QGDILEGPTRESAFRVYLAEYRNASKNDKLSILACKVIDTSTAP-RDFVKKFLPREIEML 379
Q ++L+ + S +V+L R +D + A KV+ +T RD V+ + R+I L
Sbjct: 131 QFELLKVLGQGSYGKVFLV--RKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDI--L 186
Query: 380 IKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQ 439
+++HP +V H FQ K ++ + ++ GDL + + E+ + + +LALA+
Sbjct: 187 AEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALD 246
Query: 440 YMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEI 499
++H L I +RD+K EN+LL ++K++DFG ++ +D ++ R+ +FCG++ Y APE+
Sbjct: 247 HLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAID---HDKRAYSFCGTIEYMAPEV 303
Query: 500 LQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQ 536
+ + + D WS G++++ ML ++PF+ K K+
Sbjct: 304 VNRRGH-TQSADWWSFGVLMFEMLTGSLPFQGKDRKE 339
Score = 100 bits (239), Expect = 2e-20
Identities = 79/281 (28%), Positives = 130/281 (46%), Gaps = 25/281 (8%)
Query: 12 NTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPRE 71
N T GY++ + +G G+Y+ + + + + A KII+ +K E
Sbjct: 481 NIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEY----AVKIIDKSKRDPS-------EE 529
Query: 72 IDVLVRLN-HPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQL 130
I++L+R HP++I + ++ Y+ M G+LL IL+ SE +A +
Sbjct: 530 IEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTI 589
Query: 131 ALGLQYLHELEIAHRDIKCENVLLT----ANFNVKLSDFGFSRFCVESDNQPVLSETYCG 186
+ YLH + HRD+K N+L + ++++ DFGF++ + L T C
Sbjct: 590 TKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNG---LLMTPCY 646
Query: 187 SMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPF----DDTRMRKLYEQQMGKKY 242
+ ++ APE+L+ + Y D+WSLG++L+ ML PF DDT L G KY
Sbjct: 647 TANFVAPEVLKRQGY-DAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSG-KY 704
Query: 243 RFRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+S K VV +L DP R +A VL W+
Sbjct: 705 ALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWV 745
Score = 87.4 bits (207), Expect = 1e-16
Identities = 62/242 (25%), Positives = 114/242 (47%), Gaps = 14/242 (5%)
Query: 356 KVIDTSTAPR--DFVKKFLPREIEMLIKLS-HPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
K DT A + D K+ EIE+L++ HP+++ ++ ++ M M G+L
Sbjct: 508 KATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGEL 567
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLT----ANQNVKLSD 468
L+ +L++ E +A + + Y+H + HRD+K N+L + +++++ D
Sbjct: 568 LDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCD 627
Query: 469 FGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMP 528
FGFA+ + T C + ++ APE+L+ Y D+WSLGI++Y ML P
Sbjct: 628 FGFAKQL---RAGNGLLMTPCYTANFVAPEVLKRQGY-DAACDIWSLGILLYTMLAGFTP 683
Query: 529 F---EDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSE 585
F D +++ + + D+ISD K ++ ML + RL ++
Sbjct: 684 FANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHP 743
Query: 586 WI 587
W+
Sbjct: 744 WV 745
>BC071567-1|AAH71567.1| 765|Homo sapiens SNRK protein protein.
Length = 765
Score = 134 bits (325), Expect = 7e-31
Identities = 87/292 (29%), Positives = 146/292 (50%), Gaps = 18/292 (6%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y L K +G G +A V L + + +A K+I+ K L +E+ + +
Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEK----VAVKVIDKTKLDT-LATGHLFQEVRCMKLV 70
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNG-CVSENQARVWTRQLALGLQYL 137
HP+++ ++ + +TK Y+ + + GD+ YI+K+ ++E+ A+ + Q+ + Y
Sbjct: 71 QHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYC 130
Query: 138 HELEIAHRDIKCENVLLTANFN-VKLSDFGFSRFCVESDNQPVLS-ETYCGSMSYAAPEI 195
H+L + HRD+K ENV+ VKL+DFGFS + QP T CGS++Y+APEI
Sbjct: 131 HKLHVVHRDLKPENVVFFEKQGLVKLTDFGFS-----NKFQPGKKLTTSCGSLAYSAPEI 185
Query: 196 LRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLE 255
L G Y D+WSLGV+LF+++ PF + + M KY V S +S E
Sbjct: 186 LLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKY----TVPSHVSKE 241
Query: 256 CKTVVKHLLEPDPGLRHSATNVLDSEWI-AMDSRLTTLNAVEAAALKRAKED 306
CK ++ +L+ DP R + + W+ +D T + + K E+
Sbjct: 242 CKDLITRMLQRDPKRRAYLEEIENHPWLQGVDPSPATKYNIPLVSYKNLSEE 293
Score = 123 bits (297), Expect = 2e-27
Identities = 78/264 (29%), Positives = 138/264 (52%), Gaps = 14/264 (5%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A KVID T L +E+ + + HP++V + + + K ++ + + GD+
Sbjct: 42 VAVKVID-KTKLDTLATGHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDM 100
Query: 413 LEFVLQRG-AVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQN-VKLSDFG 470
+++++ + ED A+ + Q+ AI Y H+L + HRD+K ENV+ Q VKL+DFG
Sbjct: 101 FDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFG 160
Query: 471 FA-RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPF 529
F+ + KKL T CGSL+Y+APEIL G Y D+WSLG+++++++ PF
Sbjct: 161 FSNKFQPGKKLT-----TSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPF 215
Query: 530 EDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI-A 588
++ + + ++ + S +S CK LI ML+ + + R + +I N W+
Sbjct: 216 QEANDSETLTMIMDCKYTVPSH----VSKECKDLITRMLQRDPKRRAYLEEIENHPWLQG 271
Query: 589 MDSRLLEWTPQETLAYKKAREEKN 612
+D ++YK EE++
Sbjct: 272 VDPSPATKYNIPLVSYKNLSEEEH 295
>BC096303-1|AAH96303.1| 740|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 3 protein.
Length = 740
Score = 134 bits (324), Expect = 9e-31
Identities = 75/256 (29%), Positives = 142/256 (55%), Gaps = 10/256 (3%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
++L K +G+G++ KV+L + D+ + A K+++ A V+ E D+LV +
Sbjct: 68 FELLKVLGQGSFGKVFLVKKILGSDA-RQLYAMKVLKKATLKVRDRVR-TKMERDILVEV 125
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH 138
NHP ++ +H FQ + K Y+ + + GDL + + K +E + + +LAL L +LH
Sbjct: 126 NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLH 185
Query: 139 ELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRG 198
L I +RD+K EN+LL ++KL+DFG S+ ++ + + + ++CG++ Y APE++
Sbjct: 186 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKK---AYSFCGTVEYMAPEVVNR 242
Query: 199 KPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKT 258
+ + + D WS GV++F ML ++PF K ++ M + + + LS E ++
Sbjct: 243 RGH-TQSADWWSFGVLMFEMLTGTLPFQG----KDRKETMTMILKAKLGMPQFLSPEAQS 297
Query: 259 VVKHLLEPDPGLRHSA 274
+++ L + +P R A
Sbjct: 298 LLRMLFKRNPANRLGA 313
Score = 120 bits (288), Expect = 2e-26
Identities = 73/264 (27%), Positives = 141/264 (53%), Gaps = 13/264 (4%)
Query: 314 HKHPPKRQGDILEGPTRESAFRVYLAEYRNASKNDKLSILACKVIDTSTAP-RDFVKKFL 372
H+ Q ++L+ + S +V+L + +D + A KV+ +T RD V+ +
Sbjct: 60 HEKADPSQFELLKVLGQGSFGKVFLV--KKILGSDARQLYAMKVLKKATLKVRDRVRTKM 117
Query: 373 PREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTR 432
R+I L++++HP +V H FQ K ++ + ++ GDL + + E+ + +
Sbjct: 118 ERDI--LVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA 175
Query: 433 QLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSL 492
+LALA+ ++H L I +RD+K EN+LL ++KL+DFG ++ +D +E ++ +FCG++
Sbjct: 176 ELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESID---HEKKAYSFCGTV 232
Query: 493 SYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRY 552
Y APE++ + + D WS G++++ ML +PF+ K K+ + K +
Sbjct: 233 EYMAPEVVNRRGH-TQSADWWSFGVLMFEMLTGTLPFQGKDRKE----TMTMILKAKLGM 287
Query: 553 IDTISDNCKRLIGLMLEPNHQNRL 576
+S + L+ ++ + N NRL
Sbjct: 288 PQFLSPEAQSLLRMLFKRNPANRL 311
Score = 99.1 bits (236), Expect = 4e-20
Identities = 82/280 (29%), Positives = 134/280 (47%), Gaps = 31/280 (11%)
Query: 16 TKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKST---LACKIIETAKAPKDFVVKFLPREI 72
T GY++ + +G G+Y+ K HK+T A KII+ +K EI
Sbjct: 419 TDGYEVKEDIGVGSYSVC-------KRCIHKATNMEFAVKIIDKSKRDPT-------EEI 464
Query: 73 DVLVRLN-HPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLA 131
++L+R HP++I + ++ Y+ + G+LL IL+ SE +A +
Sbjct: 465 EILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTIT 524
Query: 132 LGLQYLHELEIAHRDIKCENVLLTANF----NVKLSDFGFSRFCVESDNQPVLSETYCGS 187
++YLH + HRD+K N+L ++++ DFGF++ + ++N L T C +
Sbjct: 525 KTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAK-QLRAENG--LLMTPCYT 581
Query: 188 MSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPF----DDTRMRKLYEQQMGKKYR 243
++ APE+L+ + Y D+WSLGV+L+ ML PF DDT L G K+
Sbjct: 582 ANFVAPEVLKRQGY-DAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSG-KFS 639
Query: 244 FRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+ +S K +V +L DP R +A VL WI
Sbjct: 640 LSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 679
Score = 89.4 bits (212), Expect = 3e-17
Identities = 58/230 (25%), Positives = 112/230 (48%), Gaps = 12/230 (5%)
Query: 366 DFVKKFLPREIEMLIKLS-HPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQE 424
D K+ EIE+L++ HP+++ ++ ++ M+ G+LL+ +L++ E
Sbjct: 454 DKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSE 513
Query: 425 DQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTAN----QNVKLSDFGFARMCVDKKL 480
+A + ++Y+H + HRD+K N+L +++++ DFGFA+ +
Sbjct: 514 REASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQL--RAE 571
Query: 481 NEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPF---EDKHIKQL 537
N + T C + ++ APE+L+ Y D+WSLG+++Y ML PF D +++
Sbjct: 572 NGLLM-TPCYTANFVAPEVLKRQGY-DAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEI 629
Query: 538 HQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+ + Y +++SD K L+ ML + RL ++ WI
Sbjct: 630 LARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 679
>BC022016-1|AAH22016.3| 587|Homo sapiens protein kinase C, iota
protein.
Length = 587
Score = 134 bits (324), Expect = 9e-31
Identities = 81/264 (30%), Positives = 140/264 (53%), Gaps = 16/264 (6%)
Query: 12 NTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPRE 71
++L + + L + +G G+YAKV L + + A K+++ D + ++ E
Sbjct: 238 SSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIY----AMKVVKKELVNDDEDIDWVQTE 293
Query: 72 IDVLVRL-NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQL 130
V + NHP L+ +HS FQ +++ + + Y GDL+ ++ + + E AR ++ ++
Sbjct: 294 KHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEI 353
Query: 131 ALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSY 190
+L L YLHE I +RD+K +NVLL + ++KL+D+G C E + T+CG+ +Y
Sbjct: 354 SLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYG---MCKEGLRPGDTTSTFCGTPNY 410
Query: 191 AAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRF------ 244
APEILRG+ Y D W+LGV++F M+ PFD +Q + Y F
Sbjct: 411 IAPEILRGEDY-GFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNT-EDYLFQVILEK 468
Query: 245 RSRVASILSLECKTVVKHLLEPDP 268
+ R+ +S++ +V+K L DP
Sbjct: 469 QIRIPRSMSVKAASVLKSFLNKDP 492
Score = 111 bits (268), Expect = 6e-24
Identities = 69/209 (33%), Positives = 114/209 (54%), Gaps = 10/209 (4%)
Query: 323 DILEGPTRESAFRVYLAEYRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKL 382
D+L R S +V L + K D+ I A KV+ D ++ E + +
Sbjct: 246 DLLRVIGRGSYAKVLLVRLK---KTDR--IYAMKVVKKELVNDDEDIDWVQTEKHVFEQA 300
Query: 383 S-HPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYM 441
S HP LV HS FQ + F + Y+ GDL+ + ++ + E+ AR ++ +++LA+ Y+
Sbjct: 301 SNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYL 360
Query: 442 HELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQ 501
HE I +RD+K +NVLL + ++KL+D+G MC + + TFCG+ +Y APEIL+
Sbjct: 361 HERGIIYRDLKLDNVLLDSEGHIKLTDYG---MCKEGLRPGDTTSTFCGTPNYIAPEILR 417
Query: 502 GTPYLPKPTDVWSLGIVVYVMLNRAMPFE 530
G Y D W+LG++++ M+ PF+
Sbjct: 418 GEDY-GFSVDWWALGVLMFEMMAGRSPFD 445
>AK222581-1|BAD96301.1| 556|Homo sapiens 3-phosphoinositide
dependent protein kinase-1 variant protein.
Length = 556
Score = 134 bits (324), Expect = 9e-31
Identities = 71/237 (29%), Positives = 130/237 (54%), Gaps = 6/237 (2%)
Query: 8 PSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKF 67
P + + +K K +GEG+++ V L ++E + A KI+E K+ V +
Sbjct: 71 PPQPRKKRPEDFKFGKILGEGSFSTVVL----ARELATSREYAIKILEKRHIIKENKVPY 126
Query: 68 LPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWT 127
+ RE DV+ RL+HP + ++ FQ K Y + Y +NG+LL YI K G E R +T
Sbjct: 127 VTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYT 186
Query: 128 RQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGS 187
++ +YLH I HRD+K EN+LL + +++++DFG ++ + +++ + ++ G+
Sbjct: 187 AEIVSASEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAK-VLSPESKQARANSFVGT 245
Query: 188 MSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRF 244
Y +PE+L K C K +DLW+LG +++ ++ PF ++++ + +Y F
Sbjct: 246 AQYVSPELLTEKSAC-KSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDF 301
Score = 111 bits (266), Expect = 1e-23
Identities = 56/213 (26%), Positives = 115/213 (53%), Gaps = 2/213 (0%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLL 413
A K+++ ++ ++ RE +++ +L HP V + FQ K + + Y + G+LL
Sbjct: 109 AIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELL 168
Query: 414 EFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFAR 473
+++ + G+ E R +T ++ A +Y+H I HRD+K EN+LL + +++++DFG A+
Sbjct: 169 KYIRKIGSFDETCTRFYTAEIVSASEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAK 228
Query: 474 MCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKH 533
+ + + + R+ +F G+ Y +PE+L K +D+W+LG ++Y ++ PF +
Sbjct: 229 V-LSPESKQARANSFVGTAQYVSPELLTEKSAC-KSSDLWALGCIIYQLVAGLPPFRAGN 286
Query: 534 IKQLHQAQINKNWKFRSRYIDTISDNCKRLIGL 566
+ Q I + F ++ D ++L+ L
Sbjct: 287 EYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVL 319
>L07598-1|AAC82496.1| 540|Homo sapiens ribosomal protein S6 kinase
2 protein.
Length = 540
Score = 134 bits (323), Expect = 1e-30
Identities = 74/251 (29%), Positives = 140/251 (55%), Gaps = 12/251 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAP-KDFVVKFLPREIDVLVR 77
++L K +G+G+Y KV+L D+ + A K+++ A +D V + R D+L
Sbjct: 60 FELLKVLGQGSYGKVFLVRKVKGSDAGQ-LYAMKVLKKATLKVRDRVRSKMER--DILAE 116
Query: 78 LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYL 137
+NHP ++ +H FQ + K Y+ + + GDL + + K +E + + +LAL L +L
Sbjct: 117 VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHL 176
Query: 138 HELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILR 197
H L I +RD+K EN+LL ++K++DFG S+ ++ D + + ++CG++ Y APE++
Sbjct: 177 HSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKR---AYSFCGTIEYMAPEVVN 233
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECK 257
+ + + D WS GV++F ML ++PF K ++ M + + + LS E +
Sbjct: 234 RRGH-TQSADWWSFGVLMFEMLTGALPFQG----KDRKETMSLILKAKLGMPQFLSGEAQ 288
Query: 258 TVVKHLLEPDP 268
++++ L + +P
Sbjct: 289 SLLRALFKRNP 299
Score = 120 bits (290), Expect = 1e-26
Identities = 69/251 (27%), Positives = 138/251 (54%), Gaps = 9/251 (3%)
Query: 287 SRLTTLNAVEAAALKRAKEDRRKLSDVHKHPPKRQGDILEGPTRESAFRVYLAEYRNASK 346
S+ ++L+ +E + + + + + + Q ++L+ + S +V+L R
Sbjct: 25 SKSSSLSRLEEEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLV--RKVKG 82
Query: 347 NDKLSILACKVIDTSTAP-RDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMR 405
+D + A KV+ +T RD V+ + R+I L +++HP +V H FQ K ++ +
Sbjct: 83 SDAGQLYAMKVLKKATLKVRDRVRSKMERDI--LAEVNHPFIVKLHYAFQTEGKLYLILD 140
Query: 406 YMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVK 465
++ GDL + + E+ + + +LALA+ ++H L I +RD+K EN+LL ++K
Sbjct: 141 FLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIK 200
Query: 466 LSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNR 525
++DFG ++ +D ++ R+ +FCG++ Y APE++ + + D WS G++++ ML
Sbjct: 201 ITDFGLSKEAID---HDKRAYSFCGTIEYMAPEVVNRRGH-TQSADWWSFGVLMFEMLTG 256
Query: 526 AMPFEDKHIKQ 536
A+PF+ K K+
Sbjct: 257 ALPFQGKDRKE 267
Score = 55.6 bits (128), Expect = 5e-07
Identities = 38/143 (26%), Positives = 66/143 (46%), Gaps = 12/143 (8%)
Query: 12 NTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPRE 71
N T GY++ + +G G+Y+ + + + + A KII +K E
Sbjct: 409 NIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEY----AVKIIGKSKRDPS-------EE 457
Query: 72 IDVLVRLN-HPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQL 130
I++L+R HP++I + ++ Y+ M G+LL IL+ SE +A +
Sbjct: 458 IEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTI 517
Query: 131 ALGLQYLHELEIAHRDIKCENVL 153
+ YLH + HRD+K N+L
Sbjct: 518 TKTMDYLHSQGVVHRDLKPSNIL 540
Score = 46.0 bits (104), Expect = 4e-04
Identities = 22/84 (26%), Positives = 44/84 (52%), Gaps = 1/84 (1%)
Query: 375 EIEMLIKLS-HPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQ 433
EIE+L++ HP+++ ++ ++ M M G+LL+ +L++ E +A
Sbjct: 457 EIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCT 516
Query: 434 LALAIQYMHELEIAHRDIKCENVL 457
+ + Y+H + HRD+K N+L
Sbjct: 517 ITKTMDYLHSQGVVHRDLKPSNIL 540
>Z84486-1|CAI21678.1| 526|Homo sapiens serum/glucocorticoid
regulated kinase protein.
Length = 526
Score = 132 bits (320), Expect = 3e-30
Identities = 73/244 (29%), Positives = 124/244 (50%), Gaps = 9/244 (3%)
Query: 8 PSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKF 67
PS + K +G+G++ KV L + ++E + A K+++ K K
Sbjct: 182 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFY----AVKVLQKKAILKKKEEKH 237
Query: 68 LPREIDVLVR-LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVW 126
+ E +VL++ + HP L+ +H FQ K Y + Y G+L ++ + C E +AR +
Sbjct: 238 IMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFY 297
Query: 127 TRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCG 186
++A L YLH L I +RD+K EN+LL + ++ L+DFG C E+ + T+CG
Sbjct: 298 AAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG---LCKENIEHNSTTSTFCG 354
Query: 187 SMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRS 246
+ Y APE+L +PY + D W LG VL+ ML PF ++Y+ + K + +
Sbjct: 355 TPEYLAPEVLHKQPY-DRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKP 413
Query: 247 RVAS 250
+ +
Sbjct: 414 NITN 417
Score = 116 bits (279), Expect = 3e-25
Identities = 68/228 (29%), Positives = 118/228 (51%), Gaps = 9/228 (3%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIK-LSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
A KV+ + +K + E +L+K + HP LV H FQ K + + Y+ G+L
Sbjct: 220 AVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGEL 279
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
+ + E +AR + ++A A+ Y+H L I +RD+K EN+LL + ++ L+DFG
Sbjct: 280 FYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG-- 337
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
+C + + + TFCG+ Y APE+L PY + D W LG V+Y ML PF +
Sbjct: 338 -LCKENIEHNSTTSTFCGTPEYLAPEVLHKQPY-DRTVDWWCLGAVLYEMLYGLPPFYSR 395
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYD 580
+ +++ +NK + + I+++ + L+ +L+ + RL D
Sbjct: 396 NTAEMYDNILNKPLQLK----PNITNSARHLLEGLLQKDRTKRLGAKD 439
>Y10032-1|CAA71138.1| 431|Homo sapiens serine/threonine protein
kinase protein.
Length = 431
Score = 132 bits (320), Expect = 3e-30
Identities = 73/244 (29%), Positives = 124/244 (50%), Gaps = 9/244 (3%)
Query: 8 PSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKF 67
PS + K +G+G++ KV L + ++E + A K+++ K K
Sbjct: 87 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFY----AVKVLQKKAILKKKEEKH 142
Query: 68 LPREIDVLVR-LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVW 126
+ E +VL++ + HP L+ +H FQ K Y + Y G+L ++ + C E +AR +
Sbjct: 143 IMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFY 202
Query: 127 TRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCG 186
++A L YLH L I +RD+K EN+LL + ++ L+DFG C E+ + T+CG
Sbjct: 203 AAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG---LCKENIEHNSTTSTFCG 259
Query: 187 SMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRS 246
+ Y APE+L +PY + D W LG VL+ ML PF ++Y+ + K + +
Sbjct: 260 TPEYLAPEVLHKQPY-DRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKP 318
Query: 247 RVAS 250
+ +
Sbjct: 319 NITN 322
Score = 116 bits (279), Expect = 3e-25
Identities = 68/228 (29%), Positives = 118/228 (51%), Gaps = 9/228 (3%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIK-LSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
A KV+ + +K + E +L+K + HP LV H FQ K + + Y+ G+L
Sbjct: 125 AVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGEL 184
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
+ + E +AR + ++A A+ Y+H L I +RD+K EN+LL + ++ L+DFG
Sbjct: 185 FYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG-- 242
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
+C + + + TFCG+ Y APE+L PY + D W LG V+Y ML PF +
Sbjct: 243 -LCKENIEHNSTTSTFCGTPEYLAPEVLHKQPY-DRTVDWWCLGAVLYEMLYGLPPFYSR 300
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYD 580
+ +++ +NK + + I+++ + L+ +L+ + RL D
Sbjct: 301 NTAEMYDNILNKPLQLK----PNITNSARHLLEGLLQKDRTKRLGAKD 344
>BC001263-1|AAH01263.1| 431|Homo sapiens serum/glucocorticoid
regulated kinase protein.
Length = 431
Score = 132 bits (320), Expect = 3e-30
Identities = 73/244 (29%), Positives = 124/244 (50%), Gaps = 9/244 (3%)
Query: 8 PSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKF 67
PS + K +G+G++ KV L + ++E + A K+++ K K
Sbjct: 87 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFY----AVKVLQKKAILKKKEEKH 142
Query: 68 LPREIDVLVR-LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVW 126
+ E +VL++ + HP L+ +H FQ K Y + Y G+L ++ + C E +AR +
Sbjct: 143 IMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFY 202
Query: 127 TRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCG 186
++A L YLH L I +RD+K EN+LL + ++ L+DFG C E+ + T+CG
Sbjct: 203 AAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG---LCKENIEHNSTTSTFCG 259
Query: 187 SMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRS 246
+ Y APE+L +PY + D W LG VL+ ML PF ++Y+ + K + +
Sbjct: 260 TPEYLAPEVLHKQPY-DRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKP 318
Query: 247 RVAS 250
+ +
Sbjct: 319 NITN 322
Score = 116 bits (279), Expect = 3e-25
Identities = 68/228 (29%), Positives = 118/228 (51%), Gaps = 9/228 (3%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIK-LSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
A KV+ + +K + E +L+K + HP LV H FQ K + + Y+ G+L
Sbjct: 125 AVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGEL 184
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
+ + E +AR + ++A A+ Y+H L I +RD+K EN+LL + ++ L+DFG
Sbjct: 185 FYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG-- 242
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
+C + + + TFCG+ Y APE+L PY + D W LG V+Y ML PF +
Sbjct: 243 -LCKENIEHNSTTSTFCGTPEYLAPEVLHKQPY-DRTVDWWCLGAVLYEMLYGLPPFYSR 300
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYD 580
+ +++ +NK + + I+++ + L+ +L+ + RL D
Sbjct: 301 NTAEMYDNILNKPLQLK----PNITNSARHLLEGLLQKDRTKRLGAKD 344
>AL355881-2|CAH72579.1| 526|Homo sapiens serum/glucocorticoid
regulated kinase protein.
Length = 526
Score = 132 bits (320), Expect = 3e-30
Identities = 73/244 (29%), Positives = 124/244 (50%), Gaps = 9/244 (3%)
Query: 8 PSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKF 67
PS + K +G+G++ KV L + ++E + A K+++ K K
Sbjct: 182 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFY----AVKVLQKKAILKKKEEKH 237
Query: 68 LPREIDVLVR-LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVW 126
+ E +VL++ + HP L+ +H FQ K Y + Y G+L ++ + C E +AR +
Sbjct: 238 IMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFY 297
Query: 127 TRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCG 186
++A L YLH L I +RD+K EN+LL + ++ L+DFG C E+ + T+CG
Sbjct: 298 AAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG---LCKENIEHNSTTSTFCG 354
Query: 187 SMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRS 246
+ Y APE+L +PY + D W LG VL+ ML PF ++Y+ + K + +
Sbjct: 355 TPEYLAPEVLHKQPY-DRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKP 413
Query: 247 RVAS 250
+ +
Sbjct: 414 NITN 417
Score = 116 bits (279), Expect = 3e-25
Identities = 68/228 (29%), Positives = 118/228 (51%), Gaps = 9/228 (3%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIK-LSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
A KV+ + +K + E +L+K + HP LV H FQ K + + Y+ G+L
Sbjct: 220 AVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGEL 279
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
+ + E +AR + ++A A+ Y+H L I +RD+K EN+LL + ++ L+DFG
Sbjct: 280 FYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG-- 337
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
+C + + + TFCG+ Y APE+L PY + D W LG V+Y ML PF +
Sbjct: 338 -LCKENIEHNSTTSTFCGTPEYLAPEVLHKQPY-DRTVDWWCLGAVLYEMLYGLPPFYSR 395
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYD 580
+ +++ +NK + + I+++ + L+ +L+ + RL D
Sbjct: 396 NTAEMYDNILNKPLQLK----PNITNSARHLLEGLLQKDRTKRLGAKD 439
>AL135839-4|CAI19721.1| 526|Homo sapiens serum/glucocorticoid
regulated kinase protein.
Length = 526
Score = 132 bits (320), Expect = 3e-30
Identities = 73/244 (29%), Positives = 124/244 (50%), Gaps = 9/244 (3%)
Query: 8 PSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKF 67
PS + K +G+G++ KV L + ++E + A K+++ K K
Sbjct: 182 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFY----AVKVLQKKAILKKKEEKH 237
Query: 68 LPREIDVLVR-LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVW 126
+ E +VL++ + HP L+ +H FQ K Y + Y G+L ++ + C E +AR +
Sbjct: 238 IMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFY 297
Query: 127 TRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCG 186
++A L YLH L I +RD+K EN+LL + ++ L+DFG C E+ + T+CG
Sbjct: 298 AAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG---LCKENIEHNSTTSTFCG 354
Query: 187 SMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRS 246
+ Y APE+L +PY + D W LG VL+ ML PF ++Y+ + K + +
Sbjct: 355 TPEYLAPEVLHKQPY-DRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKP 413
Query: 247 RVAS 250
+ +
Sbjct: 414 NITN 417
Score = 116 bits (279), Expect = 3e-25
Identities = 68/228 (29%), Positives = 118/228 (51%), Gaps = 9/228 (3%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIK-LSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
A KV+ + +K + E +L+K + HP LV H FQ K + + Y+ G+L
Sbjct: 220 AVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGEL 279
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
+ + E +AR + ++A A+ Y+H L I +RD+K EN+LL + ++ L+DFG
Sbjct: 280 FYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG-- 337
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
+C + + + TFCG+ Y APE+L PY + D W LG V+Y ML PF +
Sbjct: 338 -LCKENIEHNSTTSTFCGTPEYLAPEVLHKQPY-DRTVDWWCLGAVLYEMLYGLPPFYSR 395
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYD 580
+ +++ +NK + + I+++ + L+ +L+ + RL D
Sbjct: 396 NTAEMYDNILNKPLQLK----PNITNSARHLLEGLLQKDRTKRLGAKD 439
>AL135839-3|CAI19720.1| 445|Homo sapiens serum/glucocorticoid
regulated kinase protein.
Length = 445
Score = 132 bits (320), Expect = 3e-30
Identities = 73/244 (29%), Positives = 124/244 (50%), Gaps = 9/244 (3%)
Query: 8 PSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKF 67
PS + K +G+G++ KV L + ++E + A K+++ K K
Sbjct: 101 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFY----AVKVLQKKAILKKKEEKH 156
Query: 68 LPREIDVLVR-LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVW 126
+ E +VL++ + HP L+ +H FQ K Y + Y G+L ++ + C E +AR +
Sbjct: 157 IMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFY 216
Query: 127 TRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCG 186
++A L YLH L I +RD+K EN+LL + ++ L+DFG C E+ + T+CG
Sbjct: 217 AAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG---LCKENIEHNSTTSTFCG 273
Query: 187 SMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRS 246
+ Y APE+L +PY + D W LG VL+ ML PF ++Y+ + K + +
Sbjct: 274 TPEYLAPEVLHKQPY-DRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKP 332
Query: 247 RVAS 250
+ +
Sbjct: 333 NITN 336
Score = 116 bits (279), Expect = 3e-25
Identities = 68/228 (29%), Positives = 118/228 (51%), Gaps = 9/228 (3%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIK-LSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
A KV+ + +K + E +L+K + HP LV H FQ K + + Y+ G+L
Sbjct: 139 AVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGEL 198
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
+ + E +AR + ++A A+ Y+H L I +RD+K EN+LL + ++ L+DFG
Sbjct: 199 FYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG-- 256
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
+C + + + TFCG+ Y APE+L PY + D W LG V+Y ML PF +
Sbjct: 257 -LCKENIEHNSTTSTFCGTPEYLAPEVLHKQPY-DRTVDWWCLGAVLYEMLYGLPPFYSR 314
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYD 580
+ +++ +NK + + I+++ + L+ +L+ + RL D
Sbjct: 315 NTAEMYDNILNKPLQLK----PNITNSARHLLEGLLQKDRTKRLGAKD 358
>AL135839-2|CAI19719.1| 431|Homo sapiens serum/glucocorticoid
regulated kinase protein.
Length = 431
Score = 132 bits (320), Expect = 3e-30
Identities = 73/244 (29%), Positives = 124/244 (50%), Gaps = 9/244 (3%)
Query: 8 PSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKF 67
PS + K +G+G++ KV L + ++E + A K+++ K K
Sbjct: 87 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFY----AVKVLQKKAILKKKEEKH 142
Query: 68 LPREIDVLVR-LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVW 126
+ E +VL++ + HP L+ +H FQ K Y + Y G+L ++ + C E +AR +
Sbjct: 143 IMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFY 202
Query: 127 TRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCG 186
++A L YLH L I +RD+K EN+LL + ++ L+DFG C E+ + T+CG
Sbjct: 203 AAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG---LCKENIEHNSTTSTFCG 259
Query: 187 SMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRS 246
+ Y APE+L +PY + D W LG VL+ ML PF ++Y+ + K + +
Sbjct: 260 TPEYLAPEVLHKQPY-DRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKP 318
Query: 247 RVAS 250
+ +
Sbjct: 319 NITN 322
Score = 116 bits (279), Expect = 3e-25
Identities = 68/228 (29%), Positives = 118/228 (51%), Gaps = 9/228 (3%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIK-LSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
A KV+ + +K + E +L+K + HP LV H FQ K + + Y+ G+L
Sbjct: 125 AVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGEL 184
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
+ + E +AR + ++A A+ Y+H L I +RD+K EN+LL + ++ L+DFG
Sbjct: 185 FYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG-- 242
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
+C + + + TFCG+ Y APE+L PY + D W LG V+Y ML PF +
Sbjct: 243 -LCKENIEHNSTTSTFCGTPEYLAPEVLHKQPY-DRTVDWWCLGAVLYEMLYGLPPFYSR 300
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYD 580
+ +++ +NK + + I+++ + L+ +L+ + RL D
Sbjct: 301 NTAEMYDNILNKPLQLK----PNITNSARHLLEGLLQKDRTKRLGAKD 344
>AL135839-1|CAI19718.1| 421|Homo sapiens serum/glucocorticoid
regulated kinase protein.
Length = 421
Score = 132 bits (320), Expect = 3e-30
Identities = 73/244 (29%), Positives = 124/244 (50%), Gaps = 9/244 (3%)
Query: 8 PSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKF 67
PS + K +G+G++ KV L + ++E + A K+++ K K
Sbjct: 77 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFY----AVKVLQKKAILKKKEEKH 132
Query: 68 LPREIDVLVR-LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVW 126
+ E +VL++ + HP L+ +H FQ K Y + Y G+L ++ + C E +AR +
Sbjct: 133 IMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFY 192
Query: 127 TRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCG 186
++A L YLH L I +RD+K EN+LL + ++ L+DFG C E+ + T+CG
Sbjct: 193 AAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG---LCKENIEHNSTTSTFCG 249
Query: 187 SMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRS 246
+ Y APE+L +PY + D W LG VL+ ML PF ++Y+ + K + +
Sbjct: 250 TPEYLAPEVLHKQPY-DRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKP 308
Query: 247 RVAS 250
+ +
Sbjct: 309 NITN 312
Score = 116 bits (279), Expect = 3e-25
Identities = 68/228 (29%), Positives = 118/228 (51%), Gaps = 9/228 (3%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIK-LSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
A KV+ + +K + E +L+K + HP LV H FQ K + + Y+ G+L
Sbjct: 115 AVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGEL 174
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
+ + E +AR + ++A A+ Y+H L I +RD+K EN+LL + ++ L+DFG
Sbjct: 175 FYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG-- 232
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
+C + + + TFCG+ Y APE+L PY + D W LG V+Y ML PF +
Sbjct: 233 -LCKENIEHNSTTSTFCGTPEYLAPEVLHKQPY-DRTVDWWCLGAVLYEMLYGLPPFYSR 290
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYD 580
+ +++ +NK + + I+++ + L+ +L+ + RL D
Sbjct: 291 NTAEMYDNILNKPLQLK----PNITNSARHLLEGLLQKDRTKRLGAKD 334
>AJ000512-1|CAA04146.1| 431|Homo sapiens serine/threonine protein
kinase protein.
Length = 431
Score = 132 bits (320), Expect = 3e-30
Identities = 73/244 (29%), Positives = 124/244 (50%), Gaps = 9/244 (3%)
Query: 8 PSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKF 67
PS + K +G+G++ KV L + ++E + A K+++ K K
Sbjct: 87 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFY----AVKVLQKKAILKKKEEKH 142
Query: 68 LPREIDVLVR-LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVW 126
+ E +VL++ + HP L+ +H FQ K Y + Y G+L ++ + C E +AR +
Sbjct: 143 IMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFY 202
Query: 127 TRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCG 186
++A L YLH L I +RD+K EN+LL + ++ L+DFG C E+ + T+CG
Sbjct: 203 AAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG---LCKENIEHNSTTSTFCG 259
Query: 187 SMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRS 246
+ Y APE+L +PY + D W LG VL+ ML PF ++Y+ + K + +
Sbjct: 260 TPEYLAPEVLHKQPY-DRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKP 318
Query: 247 RVAS 250
+ +
Sbjct: 319 NITN 322
Score = 116 bits (279), Expect = 3e-25
Identities = 68/228 (29%), Positives = 118/228 (51%), Gaps = 9/228 (3%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIK-LSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
A KV+ + +K + E +L+K + HP LV H FQ K + + Y+ G+L
Sbjct: 125 AVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGEL 184
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
+ + E +AR + ++A A+ Y+H L I +RD+K EN+LL + ++ L+DFG
Sbjct: 185 FYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG-- 242
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
+C + + + TFCG+ Y APE+L PY + D W LG V+Y ML PF +
Sbjct: 243 -LCKENIEHNSTTSTFCGTPEYLAPEVLHKQPY-DRTVDWWCLGAVLYEMLYGLPPFYSR 300
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYD 580
+ +++ +NK + + I+++ + L+ +L+ + RL D
Sbjct: 301 NTAEMYDNILNKPLQLK----PNITNSARHLLEGLLQKDRTKRLGAKD 344
>AF153609-1|AAD41091.1| 431|Homo sapiens serine/threonine protein
kinase sgk protein.
Length = 431
Score = 132 bits (320), Expect = 3e-30
Identities = 73/244 (29%), Positives = 124/244 (50%), Gaps = 9/244 (3%)
Query: 8 PSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKF 67
PS + K +G+G++ KV L + ++E + A K+++ K K
Sbjct: 87 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFY----AVKVLQKKAILKKKEEKH 142
Query: 68 LPREIDVLVR-LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVW 126
+ E +VL++ + HP L+ +H FQ K Y + Y G+L ++ + C E +AR +
Sbjct: 143 IMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFY 202
Query: 127 TRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCG 186
++A L YLH L I +RD+K EN+LL + ++ L+DFG C E+ + T+CG
Sbjct: 203 AAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG---LCKENIEHNSTTSTFCG 259
Query: 187 SMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRS 246
+ Y APE+L +PY + D W LG VL+ ML PF ++Y+ + K + +
Sbjct: 260 TPEYLAPEVLHKQPY-DRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKP 318
Query: 247 RVAS 250
+ +
Sbjct: 319 NITN 322
Score = 116 bits (279), Expect = 3e-25
Identities = 68/228 (29%), Positives = 118/228 (51%), Gaps = 9/228 (3%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIK-LSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
A KV+ + +K + E +L+K + HP LV H FQ K + + Y+ G+L
Sbjct: 125 AVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGEL 184
Query: 413 LEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFA 472
+ + E +AR + ++A A+ Y+H L I +RD+K EN+LL + ++ L+DFG
Sbjct: 185 FYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG-- 242
Query: 473 RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDK 532
+C + + + TFCG+ Y APE+L PY + D W LG V+Y ML PF +
Sbjct: 243 -LCKENIEHNSTTSTFCGTPEYLAPEVLHKQPY-DRTVDWWCLGAVLYEMLYGLPPFYSR 300
Query: 533 HIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYD 580
+ +++ +NK + + I+++ + L+ +L+ + RL D
Sbjct: 301 NTAEMYDNILNKPLQLK----PNITNSARHLLEGLLQKDRTKRLGAKD 344
>BC017187-1|AAH17187.1| 549|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 5 protein.
Length = 549
Score = 130 bits (315), Expect = 1e-29
Identities = 78/258 (30%), Positives = 137/258 (53%), Gaps = 6/258 (2%)
Query: 17 KGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAK-APKDFVVKFLPREIDVL 75
+ ++L K +G GAY KV+L S D+ K A K+++ A K + E VL
Sbjct: 47 ENFELLKVLGTGAYGKVFLVRKISGHDTGK-LYAMKVLKKATIVQKAKTTEHTRTERQVL 105
Query: 76 VRLNH-PHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGL 134
+ P L+ +H FQ +TK ++ + Y G+L +++ + +E++ +++ ++ L L
Sbjct: 106 EHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLAL 165
Query: 135 QYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPE 194
++LH+L I +RDIK EN+LL +N +V L+DFG S+ V + + S +CG++ Y AP+
Sbjct: 166 EHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYS--FCGTIEYMAPD 223
Query: 195 ILR-GKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILS 253
I+R G K D WSLGV+++ +L + PF + + + + +S
Sbjct: 224 IVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMS 283
Query: 254 LECKTVVKHLLEPDPGLR 271
K +++ LL DP R
Sbjct: 284 ALAKDLIQRLLMKDPKKR 301
Score = 111 bits (268), Expect = 6e-24
Identities = 76/239 (31%), Positives = 126/239 (52%), Gaps = 7/239 (2%)
Query: 342 RNASKNDKLSILACKVIDTST-APRDFVKKFLPREIEMLIKLSH-PHLVHTHSIFQRRYK 399
R S +D + A KV+ +T + + E ++L + P LV H FQ K
Sbjct: 67 RKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETK 126
Query: 400 YFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLT 459
+ + Y+ G+L + QR E + +I+ ++ LA++++H+L I +RDIK EN+LL
Sbjct: 127 LHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLD 186
Query: 460 ANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQ-GTPYLPKPTDVWSLGIV 518
+N +V L+DFG ++ V + R+ +FCG++ Y AP+I++ G K D WSLG++
Sbjct: 187 SNGHVVLTDFGLSKEFVADETE--RAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVL 244
Query: 519 VYVMLNRAMPFEDKHIKQLHQAQINKN-WKFRSRYIDTISDNCKRLIGLMLEPNHQNRL 576
+Y +L A PF K QA+I++ K Y +S K LI +L + + RL
Sbjct: 245 MYELLTGASPFTVDGEKN-SQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRL 302
Score = 53.2 bits (122), Expect = 3e-06
Identities = 22/71 (30%), Positives = 40/71 (56%)
Query: 384 HPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHE 443
HP++V H +F + F+ M + G+L E + ++ E +A R+L A+ +MH+
Sbjct: 478 HPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHD 537
Query: 444 LEIAHRDIKCE 454
+ + HRD+K E
Sbjct: 538 VGVVHRDLKPE 548
Score = 49.6 bits (113), Expect = 3e-05
Identities = 20/71 (28%), Positives = 38/71 (53%)
Query: 80 HPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLHE 139
HP+++ +H +F + ++ M G+L I K SE +A R+L + ++H+
Sbjct: 478 HPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHD 537
Query: 140 LEIAHRDIKCE 150
+ + HRD+K E
Sbjct: 538 VGVVHRDLKPE 548
>AF090421-1|AAC69577.1| 809|Homo sapiens ribosome S6 protein kinase
protein.
Length = 809
Score = 130 bits (315), Expect = 1e-29
Identities = 78/258 (30%), Positives = 137/258 (53%), Gaps = 6/258 (2%)
Query: 17 KGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAK-APKDFVVKFLPREIDVL 75
+ ++L K +G GAY KV+L S D+ K A K+++ A K + E VL
Sbjct: 47 ENFELLKVLGTGAYGKVFLVRKISGHDTGK-LYAMKVLKKATIVQKAKTTEHTRTERQVL 105
Query: 76 VRLNH-PHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGL 134
+ P L+ +H FQ +TK ++ + Y G+L +++ + +E++ +++ ++ L L
Sbjct: 106 EHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLAL 165
Query: 135 QYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPE 194
++LH+L I +RDIK EN+LL +N +V L+DFG S+ V + + S +CG++ Y AP+
Sbjct: 166 EHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYS--FCGTIEYMAPD 223
Query: 195 ILR-GKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILS 253
I+R G K D WSLGV+++ +L + PF + + + + +S
Sbjct: 224 IVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMS 283
Query: 254 LECKTVVKHLLEPDPGLR 271
K +++ LL DP R
Sbjct: 284 ALAKDLIQRLLMKDPKKR 301
Score = 114 bits (274), Expect = 1e-24
Identities = 69/222 (31%), Positives = 115/222 (51%), Gaps = 14/222 (6%)
Query: 80 HPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLHE 139
HP+++ +H +F + ++ M G+L + K SE +A R+L L ++H+
Sbjct: 478 HPNIVKLHEVFHDQLHTFLVMELLNGGELFDALRKKKHFSETEASYIMRKLVSALSHMHD 537
Query: 140 LEIAHRDIKCENVLLT---ANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEIL 196
L + HRD+K EN+L T N +K+ DFGF+R DNQP+ +T C ++ PE+L
Sbjct: 538 LGVVHRDLKPENLLFTDENDNLEIKIIDFGFARL-KPPDNQPL--KTPCFTLHSCRPELL 594
Query: 197 RGKPYCPKPTDLWSLGVVLFVMLNKSMPFD--DTRMRKLYEQQMGKK-----YRFRSRVA 249
Y + DLWSLGV+L+ ML+ +PF D + ++ KK + F
Sbjct: 595 NQNGY-DESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAW 653
Query: 250 SILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRLTT 291
+S E K +++ LL DP R + + +EW+ S+L++
Sbjct: 654 KNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSS 695
Score = 111 bits (268), Expect = 6e-24
Identities = 76/239 (31%), Positives = 126/239 (52%), Gaps = 7/239 (2%)
Query: 342 RNASKNDKLSILACKVIDTST-APRDFVKKFLPREIEMLIKLSH-PHLVHTHSIFQRRYK 399
R S +D + A KV+ +T + + E ++L + P LV H FQ K
Sbjct: 67 RKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETK 126
Query: 400 YFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLT 459
+ + Y+ G+L + QR E + +I+ ++ LA++++H+L I +RDIK EN+LL
Sbjct: 127 LHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLD 186
Query: 460 ANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQ-GTPYLPKPTDVWSLGIV 518
+N +V L+DFG ++ V + R+ +FCG++ Y AP+I++ G K D WSLG++
Sbjct: 187 SNGHVVLTDFGLSKEFVADETE--RAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVL 244
Query: 519 VYVMLNRAMPFEDKHIKQLHQAQINKN-WKFRSRYIDTISDNCKRLIGLMLEPNHQNRL 576
+Y +L A PF K QA+I++ K Y +S K LI +L + + RL
Sbjct: 245 MYELLTGASPFTVDGEKN-SQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRL 302
Score = 107 bits (258), Expect = 9e-23
Identities = 67/220 (30%), Positives = 114/220 (51%), Gaps = 14/220 (6%)
Query: 384 HPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHE 443
HP++V H +F + F+ M + G+L + + ++ E +A R+L A+ +MH+
Sbjct: 478 HPNIVKLHEVFHDQLHTFLVMELLNGGELFDALRKKKHFSETEASYIMRKLVSALSHMHD 537
Query: 444 LEIAHRDIKCENVLLT---ANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEIL 500
L + HRD+K EN+L T N +K+ DFGFAR+ K + +T C +L PE+L
Sbjct: 538 LGVVHRDLKPENLLFTDENDNLEIKIIDFGFARL---KPPDNQPLKTPCFTLHSCRPELL 594
Query: 501 QGTPYLPKPTDVWSLGIVVYVMLNRAMPFE--DKHIKQLHQAQINK-----NWKFRSRYI 553
Y + D+WSLG+++Y ML+ +PF+ D+ + +I K ++ F
Sbjct: 595 NQNGY-DESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAW 653
Query: 554 DTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRL 593
+S K LI +L + RLK+ + +EW+ S+L
Sbjct: 654 KNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQL 693
>AF080000-1|AAD23915.1| 802|Homo sapiens RSK-like protein kinase
RLPK protein.
Length = 802
Score = 130 bits (315), Expect = 1e-29
Identities = 78/258 (30%), Positives = 137/258 (53%), Gaps = 6/258 (2%)
Query: 17 KGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAK-APKDFVVKFLPREIDVL 75
+ ++L K +G GAY KV+L S D+ K A K+++ A K + E VL
Sbjct: 47 ENFELLKVLGTGAYGKVFLVRKISGHDTGK-LYAMKVLKKATIVQKAKTTEHTRTERQVL 105
Query: 76 VRLNH-PHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGL 134
+ P L+ +H FQ +TK ++ + Y G+L +++ + +E++ +++ ++ L L
Sbjct: 106 EHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLAL 165
Query: 135 QYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPE 194
++LH+L I +RDIK EN+LL +N +V L+DFG S+ V + + S +CG++ Y AP+
Sbjct: 166 EHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYS--FCGTIEYMAPD 223
Query: 195 ILR-GKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILS 253
I+R G K D WSLGV+++ +L + PF + + + + +S
Sbjct: 224 IVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMS 283
Query: 254 LECKTVVKHLLEPDPGLR 271
K +++ LL DP R
Sbjct: 284 ALAKDLIQRLLMKDPKKR 301
Score = 120 bits (288), Expect = 2e-26
Identities = 71/222 (31%), Positives = 118/222 (53%), Gaps = 14/222 (6%)
Query: 80 HPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLHE 139
HP+++ +H +F + ++ M G+L I K SE +A R+L + ++H+
Sbjct: 478 HPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHD 537
Query: 140 LEIAHRDIKCENVLLT---ANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEIL 196
+ + HRD+K EN+L T N +K+ DFGF+R DNQP+ +T C ++ YAAPE+L
Sbjct: 538 VGVVHRDLKPENLLFTDENDNLEIKIIDFGFARL-KPPDNQPL--KTPCFTLHYAAPELL 594
Query: 197 RGKPYCPKPTDLWSLGVVLFVMLNKSMPFD--DTRMRKLYEQQMGKK-----YRFRSRVA 249
Y + DLWSLGV+L+ ML+ +PF D + ++ KK + F
Sbjct: 595 NQNGY-DESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAW 653
Query: 250 SILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRLTT 291
+S E K +++ LL DP R + + +EW+ S+L++
Sbjct: 654 KNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSS 695
Score = 114 bits (275), Expect = 8e-25
Identities = 69/220 (31%), Positives = 116/220 (52%), Gaps = 14/220 (6%)
Query: 384 HPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHE 443
HP++V H +F + F+ M + G+L E + ++ E +A R+L A+ +MH+
Sbjct: 478 HPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHD 537
Query: 444 LEIAHRDIKCENVLLT---ANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEIL 500
+ + HRD+K EN+L T N +K+ DFGFAR+ K + +T C +L Y APE+L
Sbjct: 538 VGVVHRDLKPENLLFTDENDNLEIKIIDFGFARL---KPPDNQPLKTPCFTLHYAAPELL 594
Query: 501 QGTPYLPKPTDVWSLGIVVYVMLNRAMPFE--DKHIKQLHQAQINK-----NWKFRSRYI 553
Y + D+WSLG+++Y ML+ +PF+ D+ + +I K ++ F
Sbjct: 595 NQNGY-DESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAW 653
Query: 554 DTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRL 593
+S K LI +L + RLK+ + +EW+ S+L
Sbjct: 654 KNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQL 693
Score = 111 bits (268), Expect = 6e-24
Identities = 76/239 (31%), Positives = 126/239 (52%), Gaps = 7/239 (2%)
Query: 342 RNASKNDKLSILACKVIDTST-APRDFVKKFLPREIEMLIKLSH-PHLVHTHSIFQRRYK 399
R S +D + A KV+ +T + + E ++L + P LV H FQ K
Sbjct: 67 RKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETK 126
Query: 400 YFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLT 459
+ + Y+ G+L + QR E + +I+ ++ LA++++H+L I +RDIK EN+LL
Sbjct: 127 LHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLD 186
Query: 460 ANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQ-GTPYLPKPTDVWSLGIV 518
+N +V L+DFG ++ V + R+ +FCG++ Y AP+I++ G K D WSLG++
Sbjct: 187 SNGHVVLTDFGLSKEFVADETE--RAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVL 244
Query: 519 VYVMLNRAMPFEDKHIKQLHQAQINKN-WKFRSRYIDTISDNCKRLIGLMLEPNHQNRL 576
+Y +L A PF K QA+I++ K Y +S K LI +L + + RL
Sbjct: 245 MYELLTGASPFTVDGEKN-SQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRL 302
>AF074393-1|AAC31171.1| 802|Homo sapiens nuclear mitogen- and
stress-activated protein kinase-1 protein.
Length = 802
Score = 130 bits (315), Expect = 1e-29
Identities = 78/258 (30%), Positives = 137/258 (53%), Gaps = 6/258 (2%)
Query: 17 KGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAK-APKDFVVKFLPREIDVL 75
+ ++L K +G GAY KV+L S D+ K A K+++ A K + E VL
Sbjct: 47 ENFELLKVLGTGAYGKVFLVRKISGHDTGK-LYAMKVLKKATIVQKAKTTEHTRTERQVL 105
Query: 76 VRLNH-PHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGL 134
+ P L+ +H FQ +TK ++ + Y G+L +++ + +E++ +++ ++ L L
Sbjct: 106 EHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLAL 165
Query: 135 QYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPE 194
++LH+L I +RDIK EN+LL +N +V L+DFG S+ V + + S +CG++ Y AP+
Sbjct: 166 EHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYS--FCGTIEYMAPD 223
Query: 195 ILR-GKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILS 253
I+R G K D WSLGV+++ +L + PF + + + + +S
Sbjct: 224 IVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMS 283
Query: 254 LECKTVVKHLLEPDPGLR 271
K +++ LL DP R
Sbjct: 284 ALAKDLIQRLLMKDPKKR 301
Score = 120 bits (288), Expect = 2e-26
Identities = 71/222 (31%), Positives = 118/222 (53%), Gaps = 14/222 (6%)
Query: 80 HPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLHE 139
HP+++ +H +F + ++ M G+L I K SE +A R+L + ++H+
Sbjct: 478 HPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHD 537
Query: 140 LEIAHRDIKCENVLLT---ANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEIL 196
+ + HRD+K EN+L T N +K+ DFGF+R DNQP+ +T C ++ YAAPE+L
Sbjct: 538 VGVVHRDLKPENLLFTDENDNLEIKIIDFGFARL-KPPDNQPL--KTPCFTLHYAAPELL 594
Query: 197 RGKPYCPKPTDLWSLGVVLFVMLNKSMPFD--DTRMRKLYEQQMGKK-----YRFRSRVA 249
Y + DLWSLGV+L+ ML+ +PF D + ++ KK + F
Sbjct: 595 NQNGY-DESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAW 653
Query: 250 SILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRLTT 291
+S E K +++ LL DP R + + +EW+ S+L++
Sbjct: 654 KNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSS 695
Score = 114 bits (275), Expect = 8e-25
Identities = 69/220 (31%), Positives = 116/220 (52%), Gaps = 14/220 (6%)
Query: 384 HPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHE 443
HP++V H +F + F+ M + G+L E + ++ E +A R+L A+ +MH+
Sbjct: 478 HPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHD 537
Query: 444 LEIAHRDIKCENVLLT---ANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEIL 500
+ + HRD+K EN+L T N +K+ DFGFAR+ K + +T C +L Y APE+L
Sbjct: 538 VGVVHRDLKPENLLFTDENDNLEIKIIDFGFARL---KPPDNQPLKTPCFTLHYAAPELL 594
Query: 501 QGTPYLPKPTDVWSLGIVVYVMLNRAMPFE--DKHIKQLHQAQINK-----NWKFRSRYI 553
Y + D+WSLG+++Y ML+ +PF+ D+ + +I K ++ F
Sbjct: 595 NQNGY-DESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAW 653
Query: 554 DTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRL 593
+S K LI +L + RLK+ + +EW+ S+L
Sbjct: 654 KNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQL 693
Score = 111 bits (268), Expect = 6e-24
Identities = 76/239 (31%), Positives = 126/239 (52%), Gaps = 7/239 (2%)
Query: 342 RNASKNDKLSILACKVIDTST-APRDFVKKFLPREIEMLIKLSH-PHLVHTHSIFQRRYK 399
R S +D + A KV+ +T + + E ++L + P LV H FQ K
Sbjct: 67 RKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETK 126
Query: 400 YFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLT 459
+ + Y+ G+L + QR E + +I+ ++ LA++++H+L I +RDIK EN+LL
Sbjct: 127 LHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLD 186
Query: 460 ANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQ-GTPYLPKPTDVWSLGIV 518
+N +V L+DFG ++ V + R+ +FCG++ Y AP+I++ G K D WSLG++
Sbjct: 187 SNGHVVLTDFGLSKEFVADETE--RAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVL 244
Query: 519 VYVMLNRAMPFEDKHIKQLHQAQINKN-WKFRSRYIDTISDNCKRLIGLMLEPNHQNRL 576
+Y +L A PF K QA+I++ K Y +S K LI +L + + RL
Sbjct: 245 MYELLTGASPFTVDGEKN-SQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRL 302
>L24959-1|AAA18251.1| 473|Homo sapiens calcium/calmodulin dependent
protein kinase protein.
Length = 473
Score = 130 bits (314), Expect = 2e-29
Identities = 87/273 (31%), Positives = 143/273 (52%), Gaps = 18/273 (6%)
Query: 15 LTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDV 74
L+ +++ +G GA + VY K+ + A K+++ K K + EI V
Sbjct: 42 LSDFFEVESELGRGATSIVY----RCKQKGTQKPYALKVLK-----KTVDKKIVRTEIGV 92
Query: 75 LVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGL 134
L+RL+HP++I + IF+ T+ + + G+L I++ G SE A +Q+ +
Sbjct: 93 LLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAV 152
Query: 135 QYLHELEIAHRDIKCENVLLTA---NFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYA 191
YLHE I HRD+K EN+L + +K++DFG S+ VE VL +T CG+ Y
Sbjct: 153 AYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKI-VE---HQVLMKTVCGTPGYC 208
Query: 192 APEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRK-LYEQQMGKKYRFRSRVAS 250
APEILRG Y P+ D+WS+G++ +++L PF D R + ++ + + +Y F S
Sbjct: 209 APEILRGCAYGPE-VDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWD 267
Query: 251 ILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+SL K +V+ L+ DP R + L W+
Sbjct: 268 EVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWV 300
Score = 125 bits (301), Expect = 6e-28
Identities = 77/269 (28%), Positives = 140/269 (52%), Gaps = 11/269 (4%)
Query: 369 KKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQAR 428
KK + EI +L++LSHP+++ IF+ + + + + G+L + ++++G E A
Sbjct: 83 KKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAA 142
Query: 429 IWTRQLALAIQYMHELEIAHRDIKCENVLLTA---NQNVKLSDFGFARMCVDKKLNEIRS 485
+Q+ A+ Y+HE I HRD+K EN+L + +K++DFG +++ +++
Sbjct: 143 DAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVE----HQVLM 198
Query: 486 ETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQ-LHQAQINK 544
+T CG+ Y APEIL+G Y P+ D+WS+GI+ Y++L PF D+ Q + + +N
Sbjct: 199 KTVCGTPGYCAPEILRGCAYGPE-VDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNC 257
Query: 545 NWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRLLEW--TPQETL 602
+ F S + D +S N K L+ ++ + + RL + + W+ + T Q+ L
Sbjct: 258 EYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKL 317
Query: 603 AYKKAREEKNKLHKTVETVELPGSSKTEH 631
AR + K V GS+ + H
Sbjct: 318 QEFNARRKLKAAVKAVVASSRLGSASSSH 346
>L17000-1|AAA35639.1| 473|Homo sapiens calcium/calmodulin-dependent
protein kinase protein.
Length = 473
Score = 130 bits (314), Expect = 2e-29
Identities = 87/273 (31%), Positives = 143/273 (52%), Gaps = 18/273 (6%)
Query: 15 LTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDV 74
L+ +++ +G GA + VY K+ + A K+++ K K + EI V
Sbjct: 42 LSDFFEVESELGRGATSIVY----RCKQKGTQKPYALKVLK-----KTVDKKIVRTEIGV 92
Query: 75 LVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGL 134
L+RL+HP++I + IF+ T+ + + G+L I++ G SE A +Q+ +
Sbjct: 93 LLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAV 152
Query: 135 QYLHELEIAHRDIKCENVLLTA---NFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYA 191
YLHE I HRD+K EN+L + +K++DFG S+ VE VL +T CG+ Y
Sbjct: 153 AYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKI-VE---HQVLMKTVCGTPGYC 208
Query: 192 APEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRK-LYEQQMGKKYRFRSRVAS 250
APEILRG Y P+ D+WS+G++ +++L PF D R + ++ + + +Y F S
Sbjct: 209 APEILRGCAYGPE-VDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWD 267
Query: 251 ILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+SL K +V+ L+ DP R + L W+
Sbjct: 268 EVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWV 300
Score = 125 bits (301), Expect = 6e-28
Identities = 77/269 (28%), Positives = 140/269 (52%), Gaps = 11/269 (4%)
Query: 369 KKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQAR 428
KK + EI +L++LSHP+++ IF+ + + + + G+L + ++++G E A
Sbjct: 83 KKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAA 142
Query: 429 IWTRQLALAIQYMHELEIAHRDIKCENVLLTA---NQNVKLSDFGFARMCVDKKLNEIRS 485
+Q+ A+ Y+HE I HRD+K EN+L + +K++DFG +++ +++
Sbjct: 143 DAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVE----HQVLM 198
Query: 486 ETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQ-LHQAQINK 544
+T CG+ Y APEIL+G Y P+ D+WS+GI+ Y++L PF D+ Q + + +N
Sbjct: 199 KTVCGTPGYCAPEILRGCAYGPE-VDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNC 257
Query: 545 NWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRLLEW--TPQETL 602
+ F S + D +S N K L+ ++ + + RL + + W+ + T Q+ L
Sbjct: 258 EYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKL 317
Query: 603 AYKKAREEKNKLHKTVETVELPGSSKTEH 631
AR + K V GS+ + H
Sbjct: 318 QEFNARRKLKAAVKAVVASSRLGSASSSH 346
>D30742-1|BAA06403.1| 473|Homo sapiens calmodulin-dependent protein
kinase IV protein.
Length = 473
Score = 130 bits (314), Expect = 2e-29
Identities = 87/273 (31%), Positives = 143/273 (52%), Gaps = 18/273 (6%)
Query: 15 LTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDV 74
L+ +++ +G GA + VY K+ + A K+++ K K + EI V
Sbjct: 42 LSDFFEVESELGRGATSIVY----RCKQKGTQKPYALKVLK-----KTVDKKIVRTEIGV 92
Query: 75 LVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGL 134
L+RL+HP++I + IF+ T+ + + G+L I++ G SE A +Q+ +
Sbjct: 93 LLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAV 152
Query: 135 QYLHELEIAHRDIKCENVLLTA---NFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYA 191
YLHE I HRD+K EN+L + +K++DFG S+ VE VL +T CG+ Y
Sbjct: 153 AYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKI-VE---HQVLMKTVCGTPGYC 208
Query: 192 APEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRK-LYEQQMGKKYRFRSRVAS 250
APEILRG Y P+ D+WS+G++ +++L PF D R + ++ + + +Y F S
Sbjct: 209 APEILRGCAYGPE-VDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWD 267
Query: 251 ILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+SL K +V+ L+ DP R + L W+
Sbjct: 268 EVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWV 300
Score = 125 bits (301), Expect = 6e-28
Identities = 77/269 (28%), Positives = 140/269 (52%), Gaps = 11/269 (4%)
Query: 369 KKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQAR 428
KK + EI +L++LSHP+++ IF+ + + + + G+L + ++++G E A
Sbjct: 83 KKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAA 142
Query: 429 IWTRQLALAIQYMHELEIAHRDIKCENVLLTA---NQNVKLSDFGFARMCVDKKLNEIRS 485
+Q+ A+ Y+HE I HRD+K EN+L + +K++DFG +++ +++
Sbjct: 143 DAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVE----HQVLM 198
Query: 486 ETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQ-LHQAQINK 544
+T CG+ Y APEIL+G Y P+ D+WS+GI+ Y++L PF D+ Q + + +N
Sbjct: 199 KTVCGTPGYCAPEILRGCAYGPE-VDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNC 257
Query: 545 NWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRLLEW--TPQETL 602
+ F S + D +S N K L+ ++ + + RL + + W+ + T Q+ L
Sbjct: 258 EYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKL 317
Query: 603 AYKKAREEKNKLHKTVETVELPGSSKTEH 631
AR + K V GS+ + H
Sbjct: 318 QEFNARRKLKAAVKAVVASSRLGSASSSH 346
>BC126182-1|AAI26183.1| 385|Homo sapiens protein serine kinase H2
protein.
Length = 385
Score = 130 bits (314), Expect = 2e-29
Identities = 78/269 (28%), Positives = 139/269 (51%), Gaps = 15/269 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAP-KDFVVKFLPREIDVLVR 77
Y + +G G++++V E + + K A K++ET + ++ V E+ VL R
Sbjct: 63 YDIKALIGTGSFSRVVRVE----QKTTKKPFAIKVMETREREGREACVS----ELSVLRR 114
Query: 78 LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYL 137
++H +++ + IF+ + + Y+ M G+L ++ G +E A + +A G++YL
Sbjct: 115 VSHRYIVQLMEIFETEDQVYMVMELATGGELFDRLIAQGSFTERDAVRILQMVADGIRYL 174
Query: 138 HELEIAHRDIKCENVLL---TANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPE 194
H L+I HR++K EN+L + ++DFG + +S + + +T CG+ Y APE
Sbjct: 175 HALQITHRNLKPENLLYYHPGEESKILITDFGLAYSGKKSGDWTM--KTLCGTPEYIAPE 232
Query: 195 ILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSL 254
+L KPY D+W+LGV+ + +L+ +PFDD +LY + + KY + +S
Sbjct: 233 VLLRKPY-TSAVDMWALGVITYALLSGFLPFDDESQTRLYRKILKGKYNYTGEPWPSISH 291
Query: 255 ECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
K + LL + G R SA LD W+
Sbjct: 292 LAKDFIDKLLILEAGHRMSAGQALDHPWV 320
Score = 103 bits (247), Expect = 2e-21
Identities = 58/216 (26%), Positives = 111/216 (51%), Gaps = 6/216 (2%)
Query: 375 EIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQL 434
E+ +L ++SH ++V IF+ + ++ M G+L + ++ +G+ E A + +
Sbjct: 108 ELSVLRRVSHRYIVQLMEIFETEDQVYMVMELATGGELFDRLIAQGSFTERDAVRILQMV 167
Query: 435 ALAIQYMHELEIAHRDIKCENVLL---TANQNVKLSDFGFARMCVDKKLNEIRSETFCGS 491
A I+Y+H L+I HR++K EN+L + ++DFG A KK + +T CG+
Sbjct: 168 ADGIRYLHALQITHRNLKPENLLYYHPGEESKILITDFGLAYS--GKKSGDWTMKTLCGT 225
Query: 492 LSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSR 551
Y APE+L PY D+W+LG++ Y +L+ +PF+D+ +L++ + + +
Sbjct: 226 PEYIAPEVLLRKPY-TSAVDMWALGVITYALLSGFLPFDDESQTRLYRKILKGKYNYTGE 284
Query: 552 YIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+IS K I +L +R+ ++ W+
Sbjct: 285 PWPSISHLAKDFIDKLLILEAGHRMSAGQALDHPWV 320
>BC126180-1|AAI26181.1| 385|Homo sapiens protein serine kinase H2
protein.
Length = 385
Score = 130 bits (314), Expect = 2e-29
Identities = 78/269 (28%), Positives = 139/269 (51%), Gaps = 15/269 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAP-KDFVVKFLPREIDVLVR 77
Y + +G G++++V E + + K A K++ET + ++ V E+ VL R
Sbjct: 63 YDIKALIGTGSFSRVVRVE----QKTTKKPFAIKVMETREREGREACVS----ELSVLRR 114
Query: 78 LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYL 137
++H +++ + IF+ + + Y+ M G+L ++ G +E A + +A G++YL
Sbjct: 115 VSHRYIVQLMEIFETEDQVYMVMELATGGELFDRLIAQGSFTERDAVRILQMVADGIRYL 174
Query: 138 HELEIAHRDIKCENVLL---TANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPE 194
H L+I HR++K EN+L + ++DFG + +S + + +T CG+ Y APE
Sbjct: 175 HALQITHRNLKPENLLYYHPGEESKILITDFGLAYSGKKSGDWTM--KTLCGTPEYIAPE 232
Query: 195 ILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSL 254
+L KPY D+W+LGV+ + +L+ +PFDD +LY + + KY + +S
Sbjct: 233 VLLRKPY-TSAVDMWALGVITYALLSGFLPFDDESQTRLYRKILKGKYNYTGEPWPSISH 291
Query: 255 ECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
K + LL + G R SA LD W+
Sbjct: 292 LAKDFIDKLLILEAGHRMSAGQALDHPWV 320
Score = 103 bits (247), Expect = 2e-21
Identities = 58/216 (26%), Positives = 111/216 (51%), Gaps = 6/216 (2%)
Query: 375 EIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQL 434
E+ +L ++SH ++V IF+ + ++ M G+L + ++ +G+ E A + +
Sbjct: 108 ELSVLRRVSHRYIVQLMEIFETEDQVYMVMELATGGELFDRLIAQGSFTERDAVRILQMV 167
Query: 435 ALAIQYMHELEIAHRDIKCENVLL---TANQNVKLSDFGFARMCVDKKLNEIRSETFCGS 491
A I+Y+H L+I HR++K EN+L + ++DFG A KK + +T CG+
Sbjct: 168 ADGIRYLHALQITHRNLKPENLLYYHPGEESKILITDFGLAYS--GKKSGDWTMKTLCGT 225
Query: 492 LSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSR 551
Y APE+L PY D+W+LG++ Y +L+ +PF+D+ +L++ + + +
Sbjct: 226 PEYIAPEVLLRKPY-TSAVDMWALGVITYALLSGFLPFDDESQTRLYRKILKGKYNYTGE 284
Query: 552 YIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+IS K I +L +R+ ++ W+
Sbjct: 285 PWPSISHLAKDFIDKLLILEAGHRMSAGQALDHPWV 320
>BC063885-1|AAH63885.1| 708|Homo sapiens NIMA (never in mitosis
gene a)-related kinase 5 protein.
Length = 708
Score = 130 bits (314), Expect = 2e-29
Identities = 84/263 (31%), Positives = 140/263 (53%), Gaps = 15/263 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y + K +G+GA+ K YL + K DS + K I K P + +E+ +L ++
Sbjct: 4 YDVIKAIGQGAFGKAYLAK--GKSDSKHCVI--KEINFEKMPIQ-EKEASKKEVILLEKM 58
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCV--SENQARVWTRQLALGLQY 136
HP+++ + FQ + +I M Y + GDL+ I + V SE+Q W Q++LGL++
Sbjct: 59 KHPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKH 118
Query: 137 LHELEIAHRDIKCENVLLTANFNV-KLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEI 195
+H+ +I HRDIK +N+ L+ N V KL DFG +R +N L+ T G+ Y +PEI
Sbjct: 119 IHDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVL---NNSMELARTCIGTPYYLSPEI 175
Query: 196 LRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLE 255
+ KPY K TD+WSLG VL+ + PF+ +++L + + + ++ S E
Sbjct: 176 CQNKPYNNK-TDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHF---APISPGFSRE 231
Query: 256 CKTVVKHLLEPDPGLRHSATNVL 278
+++ L + P R S ++L
Sbjct: 232 LHSLISQLFQVSPRDRPSINSIL 254
Score = 118 bits (285), Expect = 5e-26
Identities = 76/218 (34%), Positives = 124/218 (56%), Gaps = 13/218 (5%)
Query: 323 DILEGPTRESAFRVYLAEYRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKL 382
D+++ + + + YLA+ ++ SK+ K I+ P K+ +E+ +L K+
Sbjct: 5 DVIKAIGQGAFGKAYLAKGKSDSKH-----CVIKEINFEKMPIQ-EKEASKKEVILLEKM 58
Query: 383 SHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFV-LQRGAV-QEDQARIWTRQLALAIQY 440
HP++V + FQ + FI M Y + GDL++ + QRG + EDQ W Q++L +++
Sbjct: 59 KHPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKH 118
Query: 441 MHELEIAHRDIKCENVLLTANQNV-KLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEI 499
+H+ +I HRDIK +N+ L+ N V KL DFG AR+ ++ + R T G+ Y +PEI
Sbjct: 119 IHDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARV-LNNSMELAR--TCIGTPYYLSPEI 175
Query: 500 LQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQL 537
Q PY K TD+WSLG V+Y + PFE +++QL
Sbjct: 176 CQNKPYNNK-TDIWSLGCVLYELCTLKHPFEGNNLQQL 212
>BC025687-1|AAH25687.1| 473|Homo sapiens
calcium/calmodulin-dependent protein kinase IV protein.
Length = 473
Score = 130 bits (314), Expect = 2e-29
Identities = 87/273 (31%), Positives = 143/273 (52%), Gaps = 18/273 (6%)
Query: 15 LTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDV 74
L+ +++ +G GA + VY K+ + A K+++ K K + EI V
Sbjct: 42 LSDFFEVESELGRGATSIVY----RCKQKGTQKPYALKVLK-----KTVDKKIVRTEIGV 92
Query: 75 LVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGL 134
L+RL+HP++I + IF+ T+ + + G+L I++ G SE A +Q+ +
Sbjct: 93 LLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAV 152
Query: 135 QYLHELEIAHRDIKCENVLLTA---NFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYA 191
YLHE I HRD+K EN+L + +K++DFG S+ VE VL +T CG+ Y
Sbjct: 153 AYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKI-VE---HQVLMKTVCGTPGYC 208
Query: 192 APEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRK-LYEQQMGKKYRFRSRVAS 250
APEILRG Y P+ D+WS+G++ +++L PF D R + ++ + + +Y F S
Sbjct: 209 APEILRGCAYGPE-VDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWD 267
Query: 251 ILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+SL K +V+ L+ DP R + L W+
Sbjct: 268 EVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWV 300
Score = 125 bits (301), Expect = 6e-28
Identities = 77/269 (28%), Positives = 140/269 (52%), Gaps = 11/269 (4%)
Query: 369 KKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQAR 428
KK + EI +L++LSHP+++ IF+ + + + + G+L + ++++G E A
Sbjct: 83 KKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAA 142
Query: 429 IWTRQLALAIQYMHELEIAHRDIKCENVLLTA---NQNVKLSDFGFARMCVDKKLNEIRS 485
+Q+ A+ Y+HE I HRD+K EN+L + +K++DFG +++ +++
Sbjct: 143 DAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVE----HQVLM 198
Query: 486 ETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQ-LHQAQINK 544
+T CG+ Y APEIL+G Y P+ D+WS+GI+ Y++L PF D+ Q + + +N
Sbjct: 199 KTVCGTPGYCAPEILRGCAYGPE-VDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNC 257
Query: 545 NWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRLLEW--TPQETL 602
+ F S + D +S N K L+ ++ + + RL + + W+ + T Q+ L
Sbjct: 258 EYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKL 317
Query: 603 AYKKAREEKNKLHKTVETVELPGSSKTEH 631
AR + K V GS+ + H
Sbjct: 318 QEFNARRKLKAAVKAVVASSRLGSASSSH 346
>BC016695-1|AAH16695.2| 503|Homo sapiens CAMK4 protein protein.
Length = 503
Score = 130 bits (314), Expect = 2e-29
Identities = 87/273 (31%), Positives = 143/273 (52%), Gaps = 18/273 (6%)
Query: 15 LTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDV 74
L+ +++ +G GA + VY K+ + A K+++ K K + EI V
Sbjct: 72 LSDFFEVESELGRGATSIVY----RCKQKGTQKPYALKVLK-----KTVDKKIVRTEIGV 122
Query: 75 LVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGL 134
L+RL+HP++I + IF+ T+ + + G+L I++ G SE A +Q+ +
Sbjct: 123 LLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAV 182
Query: 135 QYLHELEIAHRDIKCENVLLTA---NFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYA 191
YLHE I HRD+K EN+L + +K++DFG S+ VE VL +T CG+ Y
Sbjct: 183 AYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKI-VE---HQVLMKTVCGTPGYC 238
Query: 192 APEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRK-LYEQQMGKKYRFRSRVAS 250
APEILRG Y P+ D+WS+G++ +++L PF D R + ++ + + +Y F S
Sbjct: 239 APEILRGCAYGPE-VDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWD 297
Query: 251 ILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+SL K +V+ L+ DP R + L W+
Sbjct: 298 EVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWV 330
Score = 125 bits (301), Expect = 6e-28
Identities = 77/269 (28%), Positives = 140/269 (52%), Gaps = 11/269 (4%)
Query: 369 KKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQAR 428
KK + EI +L++LSHP+++ IF+ + + + + G+L + ++++G E A
Sbjct: 113 KKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAA 172
Query: 429 IWTRQLALAIQYMHELEIAHRDIKCENVLLTA---NQNVKLSDFGFARMCVDKKLNEIRS 485
+Q+ A+ Y+HE I HRD+K EN+L + +K++DFG +++ +++
Sbjct: 173 DAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVE----HQVLM 228
Query: 486 ETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQ-LHQAQINK 544
+T CG+ Y APEIL+G Y P+ D+WS+GI+ Y++L PF D+ Q + + +N
Sbjct: 229 KTVCGTPGYCAPEILRGCAYGPE-VDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNC 287
Query: 545 NWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDSRLLEW--TPQETL 602
+ F S + D +S N K L+ ++ + + RL + + W+ + T Q+ L
Sbjct: 288 EYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKL 347
Query: 603 AYKKAREEKNKLHKTVETVELPGSSKTEH 631
AR + K V GS+ + H
Sbjct: 348 QEFNARRKLKAAVKAVVASSRLGSASSSH 376
>AY037806-1|AAK59985.1| 385|Homo sapiens serine/threonine kinase
PSKH2 protein.
Length = 385
Score = 130 bits (314), Expect = 2e-29
Identities = 78/269 (28%), Positives = 139/269 (51%), Gaps = 15/269 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAP-KDFVVKFLPREIDVLVR 77
Y + +G G++++V E + + K A K++ET + ++ V E+ VL R
Sbjct: 63 YDIKALIGTGSFSRVVRVE----QKTTKKPFAIKVMETREREGREACVS----ELSVLRR 114
Query: 78 LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYL 137
++H +++ + IF+ + + Y+ M G+L ++ G +E A + +A G++YL
Sbjct: 115 VSHRYIVQLMEIFETEDQVYMVMELATGGELFDRLIAQGSFTERDAVRILQMVADGIRYL 174
Query: 138 HELEIAHRDIKCENVLL---TANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPE 194
H L+I HR++K EN+L + ++DFG + +S + + +T CG+ Y APE
Sbjct: 175 HALQITHRNLKPENLLYYHPGEESKILITDFGLAYSGKKSGDWTM--KTLCGTPEYIAPE 232
Query: 195 ILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSL 254
+L KPY D+W+LGV+ + +L+ +PFDD +LY + + KY + +S
Sbjct: 233 VLLRKPY-TSAVDMWALGVITYALLSGFLPFDDESQTRLYRKILKGKYNYTGEPWPSISH 291
Query: 255 ECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
K + LL + G R SA LD W+
Sbjct: 292 LAKDFIDKLLILEAGHRMSAGQALDHPWV 320
Score = 103 bits (247), Expect = 2e-21
Identities = 58/216 (26%), Positives = 111/216 (51%), Gaps = 6/216 (2%)
Query: 375 EIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQL 434
E+ +L ++SH ++V IF+ + ++ M G+L + ++ +G+ E A + +
Sbjct: 108 ELSVLRRVSHRYIVQLMEIFETEDQVYMVMELATGGELFDRLIAQGSFTERDAVRILQMV 167
Query: 435 ALAIQYMHELEIAHRDIKCENVLL---TANQNVKLSDFGFARMCVDKKLNEIRSETFCGS 491
A I+Y+H L+I HR++K EN+L + ++DFG A KK + +T CG+
Sbjct: 168 ADGIRYLHALQITHRNLKPENLLYYHPGEESKILITDFGLAYS--GKKSGDWTMKTLCGT 225
Query: 492 LSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSR 551
Y APE+L PY D+W+LG++ Y +L+ +PF+D+ +L++ + + +
Sbjct: 226 PEYIAPEVLLRKPY-TSAVDMWALGVITYALLSGFLPFDDESQTRLYRKILKGKYNYTGE 284
Query: 552 YIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+IS K I +L +R+ ++ W+
Sbjct: 285 PWPSISHLAKDFIDKLLILEAGHRMSAGQALDHPWV 320
>AL139082-5|CAI12892.2| 708|Homo sapiens NIMA (never in mitosis
gene a)-related kinase 5 protein.
Length = 708
Score = 130 bits (314), Expect = 2e-29
Identities = 84/263 (31%), Positives = 140/263 (53%), Gaps = 15/263 (5%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y + K +G+GA+ K YL + K DS + K I K P + +E+ +L ++
Sbjct: 4 YDVIKAIGQGAFGKAYLAK--GKSDSKHCVI--KEINFEKMPIQ-EKEASKKEVILLEKM 58
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCV--SENQARVWTRQLALGLQY 136
HP+++ + FQ + +I M Y + GDL+ I + V SE+Q W Q++LGL++
Sbjct: 59 KHPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKH 118
Query: 137 LHELEIAHRDIKCENVLLTANFNV-KLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEI 195
+H+ +I HRDIK +N+ L+ N V KL DFG +R +N L+ T G+ Y +PEI
Sbjct: 119 IHDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVL---NNSMELARTCIGTPYYLSPEI 175
Query: 196 LRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLE 255
+ KPY K TD+WSLG VL+ + PF+ +++L + + + ++ S E
Sbjct: 176 CQNKPYNNK-TDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHF---APISPGFSRE 231
Query: 256 CKTVVKHLLEPDPGLRHSATNVL 278
+++ L + P R S ++L
Sbjct: 232 LHSLISQLFQVSPRDRPSINSIL 254
Score = 118 bits (285), Expect = 5e-26
Identities = 76/218 (34%), Positives = 124/218 (56%), Gaps = 13/218 (5%)
Query: 323 DILEGPTRESAFRVYLAEYRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKL 382
D+++ + + + YLA+ ++ SK+ K I+ P K+ +E+ +L K+
Sbjct: 5 DVIKAIGQGAFGKAYLAKGKSDSKH-----CVIKEINFEKMPIQ-EKEASKKEVILLEKM 58
Query: 383 SHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFV-LQRGAV-QEDQARIWTRQLALAIQY 440
HP++V + FQ + FI M Y + GDL++ + QRG + EDQ W Q++L +++
Sbjct: 59 KHPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKH 118
Query: 441 MHELEIAHRDIKCENVLLTANQNV-KLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEI 499
+H+ +I HRDIK +N+ L+ N V KL DFG AR+ ++ + R T G+ Y +PEI
Sbjct: 119 IHDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARV-LNNSMELAR--TCIGTPYYLSPEI 175
Query: 500 LQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQL 537
Q PY K TD+WSLG V+Y + PFE +++QL
Sbjct: 176 CQNKPYNNK-TDIWSLGCVLYELCTLKHPFEGNNLQQL 212
>CR456418-1|CAG30304.1| 586|Homo sapiens CHEK2 protein.
Length = 586
Score = 130 bits (313), Expect = 2e-29
Identities = 89/273 (32%), Positives = 140/273 (51%), Gaps = 14/273 (5%)
Query: 19 YKLTKFVGEGAYAKVYLT--EYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLV 76
Y ++K +G GA +V L + K+ + K K + D + + EI++L
Sbjct: 263 YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALN-VETEIEILK 321
Query: 77 RLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQY 136
+LNHP +I + + F + YYI + E G+L ++ N + E +++ Q+ L +QY
Sbjct: 322 KLNHPCIIKIKNFFDAED-YYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQY 380
Query: 137 LHELEIAHRDIKCENVLLTANFN---VKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAP 193
LHE I HRD+K ENVLL++ +K++DFG S+ E+ L T CG+ +Y AP
Sbjct: 381 LHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS----LMRTLCGTPTYLAP 436
Query: 194 EIL--RGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMR-KLYEQQMGKKYRFRSRVAS 250
E+L G + D WSLGV+LF+ L+ PF + R + L +Q KY F V +
Sbjct: 437 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 496
Query: 251 ILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+S + +VK LL DP R + L W+
Sbjct: 497 EVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 529
Score = 112 bits (269), Expect = 4e-24
Identities = 72/258 (27%), Positives = 130/258 (50%), Gaps = 11/258 (4%)
Query: 336 VYLAEYRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQ 395
V LA R K + I++ + +A + EIE+L KL+HP ++ + F
Sbjct: 277 VKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFD 336
Query: 396 RRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCEN 455
Y+I + ME G+L + V+ ++E +++ Q+ LA+QY+HE I HRD+K EN
Sbjct: 337 AE-DYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPEN 395
Query: 456 VLLTANQN---VKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEIL--QGTPYLPKPT 510
VLL++ + +K++DFG +++ + L T CG+ +Y APE+L GT +
Sbjct: 396 VLLSSQEEDCLIKITDFGHSKILGETSL----MRTLCGTPTYLAPEVLVSVGTAGYNRAV 451
Query: 511 DVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINK-NWKFRSRYIDTISDNCKRLIGLMLE 569
D WSLG+++++ L+ PF + + + QI + F +S+ L+ +L
Sbjct: 452 DCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLV 511
Query: 570 PNHQNRLKIYDIVNSEWI 587
+ + R + + W+
Sbjct: 512 VDPKARFTTEEALRHPWL 529
>BC004207-1|AAH04207.1| 543|Homo sapiens CHK2 checkpoint homolog
(S. pombe) protein.
Length = 543
Score = 130 bits (313), Expect = 2e-29
Identities = 89/273 (32%), Positives = 140/273 (51%), Gaps = 14/273 (5%)
Query: 19 YKLTKFVGEGAYAKVYLT--EYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLV 76
Y ++K +G GA +V L + K+ + K K + D + + EI++L
Sbjct: 220 YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALN-VETEIEILK 278
Query: 77 RLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQY 136
+LNHP +I + + F + YYI + E G+L ++ N + E +++ Q+ L +QY
Sbjct: 279 KLNHPCIIKIKNFFDAED-YYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQY 337
Query: 137 LHELEIAHRDIKCENVLLTANFN---VKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAP 193
LHE I HRD+K ENVLL++ +K++DFG S+ E+ L T CG+ +Y AP
Sbjct: 338 LHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS----LMRTLCGTPTYLAP 393
Query: 194 EIL--RGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMR-KLYEQQMGKKYRFRSRVAS 250
E+L G + D WSLGV+LF+ L+ PF + R + L +Q KY F V +
Sbjct: 394 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 453
Query: 251 ILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+S + +VK LL DP R + L W+
Sbjct: 454 EVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 486
Score = 112 bits (269), Expect = 4e-24
Identities = 72/258 (27%), Positives = 130/258 (50%), Gaps = 11/258 (4%)
Query: 336 VYLAEYRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQ 395
V LA R K + I++ + +A + EIE+L KL+HP ++ + F
Sbjct: 234 VKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFD 293
Query: 396 RRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCEN 455
Y+I + ME G+L + V+ ++E +++ Q+ LA+QY+HE I HRD+K EN
Sbjct: 294 AE-DYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPEN 352
Query: 456 VLLTANQN---VKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEIL--QGTPYLPKPT 510
VLL++ + +K++DFG +++ + L T CG+ +Y APE+L GT +
Sbjct: 353 VLLSSQEEDCLIKITDFGHSKILGETSL----MRTLCGTPTYLAPEVLVSVGTAGYNRAV 408
Query: 511 DVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINK-NWKFRSRYIDTISDNCKRLIGLMLE 569
D WSLG+++++ L+ PF + + + QI + F +S+ L+ +L
Sbjct: 409 DCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLV 468
Query: 570 PNHQNRLKIYDIVNSEWI 587
+ + R + + W+
Sbjct: 469 VDPKARFTTEEALRHPWL 486
>AY800241-1|AAV41895.1| 543|Homo sapiens CHK2 checkpoint homolog
(S. pombe) protein.
Length = 543
Score = 130 bits (313), Expect = 2e-29
Identities = 89/273 (32%), Positives = 140/273 (51%), Gaps = 14/273 (5%)
Query: 19 YKLTKFVGEGAYAKVYLT--EYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLV 76
Y ++K +G GA +V L + K+ + K K + D + + EI++L
Sbjct: 220 YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALN-VETEIEILK 278
Query: 77 RLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQY 136
+LNHP +I + + F + YYI + E G+L ++ N + E +++ Q+ L +QY
Sbjct: 279 KLNHPCIIKIKNFFDAED-YYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQY 337
Query: 137 LHELEIAHRDIKCENVLLTANFN---VKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAP 193
LHE I HRD+K ENVLL++ +K++DFG S+ E+ L T CG+ +Y AP
Sbjct: 338 LHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS----LMRTLCGTPTYLAP 393
Query: 194 EIL--RGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMR-KLYEQQMGKKYRFRSRVAS 250
E+L G + D WSLGV+LF+ L+ PF + R + L +Q KY F V +
Sbjct: 394 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 453
Query: 251 ILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+S + +VK LL DP R + L W+
Sbjct: 454 EVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 486
Score = 112 bits (269), Expect = 4e-24
Identities = 72/258 (27%), Positives = 130/258 (50%), Gaps = 11/258 (4%)
Query: 336 VYLAEYRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQ 395
V LA R K + I++ + +A + EIE+L KL+HP ++ + F
Sbjct: 234 VKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFD 293
Query: 396 RRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCEN 455
Y+I + ME G+L + V+ ++E +++ Q+ LA+QY+HE I HRD+K EN
Sbjct: 294 AE-DYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPEN 352
Query: 456 VLLTANQN---VKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEIL--QGTPYLPKPT 510
VLL++ + +K++DFG +++ + L T CG+ +Y APE+L GT +
Sbjct: 353 VLLSSQEEDCLIKITDFGHSKILGETSL----MRTLCGTPTYLAPEVLVSVGTAGYNRAV 408
Query: 511 DVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINK-NWKFRSRYIDTISDNCKRLIGLMLE 569
D WSLG+++++ L+ PF + + + QI + F +S+ L+ +L
Sbjct: 409 DCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLV 468
Query: 570 PNHQNRLKIYDIVNSEWI 587
+ + R + + W+
Sbjct: 469 VDPKARFTTEEALRHPWL 486
>AY551303-1|AAS58464.1| 452|Homo sapiens protein kinase Chk2
transcript variant del2-3 protein.
Length = 452
Score = 130 bits (313), Expect = 2e-29
Identities = 89/273 (32%), Positives = 140/273 (51%), Gaps = 14/273 (5%)
Query: 19 YKLTKFVGEGAYAKVYLT--EYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLV 76
Y ++K +G GA +V L + K+ + K K + D + + EI++L
Sbjct: 129 YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALN-VETEIEILK 187
Query: 77 RLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQY 136
+LNHP +I + + F + YYI + E G+L ++ N + E +++ Q+ L +QY
Sbjct: 188 KLNHPCIIKIKNFFDAED-YYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQY 246
Query: 137 LHELEIAHRDIKCENVLLTANFN---VKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAP 193
LHE I HRD+K ENVLL++ +K++DFG S+ E+ L T CG+ +Y AP
Sbjct: 247 LHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS----LMRTLCGTPTYLAP 302
Query: 194 EIL--RGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMR-KLYEQQMGKKYRFRSRVAS 250
E+L G + D WSLGV+LF+ L+ PF + R + L +Q KY F V +
Sbjct: 303 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 362
Query: 251 ILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+S + +VK LL DP R + L W+
Sbjct: 363 EVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 395
Score = 112 bits (269), Expect = 4e-24
Identities = 72/258 (27%), Positives = 130/258 (50%), Gaps = 11/258 (4%)
Query: 336 VYLAEYRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQ 395
V LA R K + I++ + +A + EIE+L KL+HP ++ + F
Sbjct: 143 VKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFD 202
Query: 396 RRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCEN 455
Y+I + ME G+L + V+ ++E +++ Q+ LA+QY+HE I HRD+K EN
Sbjct: 203 AE-DYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPEN 261
Query: 456 VLLTANQN---VKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEIL--QGTPYLPKPT 510
VLL++ + +K++DFG +++ + L T CG+ +Y APE+L GT +
Sbjct: 262 VLLSSQEEDCLIKITDFGHSKILGETSL----MRTLCGTPTYLAPEVLVSVGTAGYNRAV 317
Query: 511 DVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINK-NWKFRSRYIDTISDNCKRLIGLMLE 569
D WSLG+++++ L+ PF + + + QI + F +S+ L+ +L
Sbjct: 318 DCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLV 377
Query: 570 PNHQNRLKIYDIVNSEWI 587
+ + R + + W+
Sbjct: 378 VDPKARFTTEEALRHPWL 395
>AY551297-1|AAS58458.1| 586|Homo sapiens protein kinase Chk2
transcript variant insX protein.
Length = 586
Score = 130 bits (313), Expect = 2e-29
Identities = 89/273 (32%), Positives = 140/273 (51%), Gaps = 14/273 (5%)
Query: 19 YKLTKFVGEGAYAKVYLT--EYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLV 76
Y ++K +G GA +V L + K+ + K K + D + + EI++L
Sbjct: 263 YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALN-VETEIEILK 321
Query: 77 RLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQY 136
+LNHP +I + + F + YYI + E G+L ++ N + E +++ Q+ L +QY
Sbjct: 322 KLNHPCIIKIKNFFDAED-YYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQY 380
Query: 137 LHELEIAHRDIKCENVLLTANFN---VKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAP 193
LHE I HRD+K ENVLL++ +K++DFG S+ E+ L T CG+ +Y AP
Sbjct: 381 LHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS----LMRTLCGTPTYLAP 436
Query: 194 EIL--RGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMR-KLYEQQMGKKYRFRSRVAS 250
E+L G + D WSLGV+LF+ L+ PF + R + L +Q KY F V +
Sbjct: 437 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 496
Query: 251 ILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+S + +VK LL DP R + L W+
Sbjct: 497 EVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 529
Score = 112 bits (269), Expect = 4e-24
Identities = 72/258 (27%), Positives = 130/258 (50%), Gaps = 11/258 (4%)
Query: 336 VYLAEYRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQ 395
V LA R K + I++ + +A + EIE+L KL+HP ++ + F
Sbjct: 277 VKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFD 336
Query: 396 RRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCEN 455
Y+I + ME G+L + V+ ++E +++ Q+ LA+QY+HE I HRD+K EN
Sbjct: 337 AE-DYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPEN 395
Query: 456 VLLTANQN---VKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEIL--QGTPYLPKPT 510
VLL++ + +K++DFG +++ + L T CG+ +Y APE+L GT +
Sbjct: 396 VLLSSQEEDCLIKITDFGHSKILGETSL----MRTLCGTPTYLAPEVLVSVGTAGYNRAV 451
Query: 511 DVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINK-NWKFRSRYIDTISDNCKRLIGLMLE 569
D WSLG+++++ L+ PF + + + QI + F +S+ L+ +L
Sbjct: 452 DCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLV 511
Query: 570 PNHQNRLKIYDIVNSEWI 587
+ + R + + W+
Sbjct: 512 VDPKARFTTEEALRHPWL 529
>AL121825-1|CAH73823.1| 543|Homo sapiens CHK2 checkpoint homolog
(S. pombe) protein.
Length = 543
Score = 130 bits (313), Expect = 2e-29
Identities = 89/273 (32%), Positives = 140/273 (51%), Gaps = 14/273 (5%)
Query: 19 YKLTKFVGEGAYAKVYLT--EYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLV 76
Y ++K +G GA +V L + K+ + K K + D + + EI++L
Sbjct: 220 YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALN-VETEIEILK 278
Query: 77 RLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQY 136
+LNHP +I + + F + YYI + E G+L ++ N + E +++ Q+ L +QY
Sbjct: 279 KLNHPCIIKIKNFFDAED-YYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQY 337
Query: 137 LHELEIAHRDIKCENVLLTANFN---VKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAP 193
LHE I HRD+K ENVLL++ +K++DFG S+ E+ L T CG+ +Y AP
Sbjct: 338 LHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS----LMRTLCGTPTYLAP 393
Query: 194 EIL--RGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMR-KLYEQQMGKKYRFRSRVAS 250
E+L G + D WSLGV+LF+ L+ PF + R + L +Q KY F V +
Sbjct: 394 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 453
Query: 251 ILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+S + +VK LL DP R + L W+
Sbjct: 454 EVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 486
Score = 112 bits (269), Expect = 4e-24
Identities = 72/258 (27%), Positives = 130/258 (50%), Gaps = 11/258 (4%)
Query: 336 VYLAEYRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQ 395
V LA R K + I++ + +A + EIE+L KL+HP ++ + F
Sbjct: 234 VKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFD 293
Query: 396 RRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCEN 455
Y+I + ME G+L + V+ ++E +++ Q+ LA+QY+HE I HRD+K EN
Sbjct: 294 AE-DYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPEN 352
Query: 456 VLLTANQN---VKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEIL--QGTPYLPKPT 510
VLL++ + +K++DFG +++ + L T CG+ +Y APE+L GT +
Sbjct: 353 VLLSSQEEDCLIKITDFGHSKILGETSL----MRTLCGTPTYLAPEVLVSVGTAGYNRAV 408
Query: 511 DVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINK-NWKFRSRYIDTISDNCKRLIGLMLE 569
D WSLG+++++ L+ PF + + + QI + F +S+ L+ +L
Sbjct: 409 DCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLV 468
Query: 570 PNHQNRLKIYDIVNSEWI 587
+ + R + + W+
Sbjct: 469 VDPKARFTTEEALRHPWL 486
>AL117330-1|CAH73875.1| 543|Homo sapiens CHK2 checkpoint homolog
(S. pombe) protein.
Length = 543
Score = 130 bits (313), Expect = 2e-29
Identities = 89/273 (32%), Positives = 140/273 (51%), Gaps = 14/273 (5%)
Query: 19 YKLTKFVGEGAYAKVYLT--EYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLV 76
Y ++K +G GA +V L + K+ + K K + D + + EI++L
Sbjct: 220 YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALN-VETEIEILK 278
Query: 77 RLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQY 136
+LNHP +I + + F + YYI + E G+L ++ N + E +++ Q+ L +QY
Sbjct: 279 KLNHPCIIKIKNFFDAED-YYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQY 337
Query: 137 LHELEIAHRDIKCENVLLTANFN---VKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAP 193
LHE I HRD+K ENVLL++ +K++DFG S+ E+ L T CG+ +Y AP
Sbjct: 338 LHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS----LMRTLCGTPTYLAP 393
Query: 194 EIL--RGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMR-KLYEQQMGKKYRFRSRVAS 250
E+L G + D WSLGV+LF+ L+ PF + R + L +Q KY F V +
Sbjct: 394 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 453
Query: 251 ILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+S + +VK LL DP R + L W+
Sbjct: 454 EVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 486
Score = 112 bits (269), Expect = 4e-24
Identities = 72/258 (27%), Positives = 130/258 (50%), Gaps = 11/258 (4%)
Query: 336 VYLAEYRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQ 395
V LA R K + I++ + +A + EIE+L KL+HP ++ + F
Sbjct: 234 VKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFD 293
Query: 396 RRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCEN 455
Y+I + ME G+L + V+ ++E +++ Q+ LA+QY+HE I HRD+K EN
Sbjct: 294 AE-DYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPEN 352
Query: 456 VLLTANQN---VKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEIL--QGTPYLPKPT 510
VLL++ + +K++DFG +++ + L T CG+ +Y APE+L GT +
Sbjct: 353 VLLSSQEEDCLIKITDFGHSKILGETSL----MRTLCGTPTYLAPEVLVSVGTAGYNRAV 408
Query: 511 DVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINK-NWKFRSRYIDTISDNCKRLIGLMLE 569
D WSLG+++++ L+ PF + + + QI + F +S+ L+ +L
Sbjct: 409 DCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLV 468
Query: 570 PNHQNRLKIYDIVNSEWI 587
+ + R + + W+
Sbjct: 469 VDPKARFTTEEALRHPWL 486
>AJ131197-1|CAA10319.1| 543|Homo sapiens protein kinase protein.
Length = 543
Score = 130 bits (313), Expect = 2e-29
Identities = 89/273 (32%), Positives = 140/273 (51%), Gaps = 14/273 (5%)
Query: 19 YKLTKFVGEGAYAKVYLT--EYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLV 76
Y ++K +G GA +V L + K+ + K K + D + + EI++L
Sbjct: 220 YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALN-VETEIEILK 278
Query: 77 RLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQY 136
+LNHP +I + + F + YYI + E G+L ++ N + E +++ Q+ L +QY
Sbjct: 279 KLNHPCIIKIKNFFDAED-YYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQY 337
Query: 137 LHELEIAHRDIKCENVLLTANFN---VKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAP 193
LHE I HRD+K ENVLL++ +K++DFG S+ E+ L T CG+ +Y AP
Sbjct: 338 LHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS----LMRTLCGTPTYLAP 393
Query: 194 EIL--RGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMR-KLYEQQMGKKYRFRSRVAS 250
E+L G + D WSLGV+LF+ L+ PF + R + L +Q KY F V +
Sbjct: 394 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 453
Query: 251 ILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+S + +VK LL DP R + L W+
Sbjct: 454 EVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 486
Score = 112 bits (269), Expect = 4e-24
Identities = 72/258 (27%), Positives = 130/258 (50%), Gaps = 11/258 (4%)
Query: 336 VYLAEYRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQ 395
V LA R K + I++ + +A + EIE+L KL+HP ++ + F
Sbjct: 234 VKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFD 293
Query: 396 RRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCEN 455
Y+I + ME G+L + V+ ++E +++ Q+ LA+QY+HE I HRD+K EN
Sbjct: 294 AE-DYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPEN 352
Query: 456 VLLTANQN---VKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEIL--QGTPYLPKPT 510
VLL++ + +K++DFG +++ + L T CG+ +Y APE+L GT +
Sbjct: 353 VLLSSQEEDCLIKITDFGHSKILGETSL----MRTLCGTPTYLAPEVLVSVGTAGYNRAV 408
Query: 511 DVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINK-NWKFRSRYIDTISDNCKRLIGLMLE 569
D WSLG+++++ L+ PF + + + QI + F +S+ L+ +L
Sbjct: 409 DCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLV 468
Query: 570 PNHQNRLKIYDIVNSEWI 587
+ + R + + W+
Sbjct: 469 VDPKARFTTEEALRHPWL 486
>AF174135-1|AAD48504.1| 543|Homo sapiens protein kinase CHK2
protein.
Length = 543
Score = 130 bits (313), Expect = 2e-29
Identities = 89/273 (32%), Positives = 140/273 (51%), Gaps = 14/273 (5%)
Query: 19 YKLTKFVGEGAYAKVYLT--EYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLV 76
Y ++K +G GA +V L + K+ + K K + D + + EI++L
Sbjct: 220 YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALN-VETEIEILK 278
Query: 77 RLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQY 136
+LNHP +I + + F + YYI + E G+L ++ N + E +++ Q+ L +QY
Sbjct: 279 KLNHPCIIKIKNFFDAED-YYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQY 337
Query: 137 LHELEIAHRDIKCENVLLTANFN---VKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAP 193
LHE I HRD+K ENVLL++ +K++DFG S+ E+ L T CG+ +Y AP
Sbjct: 338 LHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS----LMRTLCGTPTYLAP 393
Query: 194 EIL--RGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMR-KLYEQQMGKKYRFRSRVAS 250
E+L G + D WSLGV+LF+ L+ PF + R + L +Q KY F V +
Sbjct: 394 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 453
Query: 251 ILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+S + +VK LL DP R + L W+
Sbjct: 454 EVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 486
Score = 112 bits (269), Expect = 4e-24
Identities = 72/258 (27%), Positives = 130/258 (50%), Gaps = 11/258 (4%)
Query: 336 VYLAEYRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQ 395
V LA R K + I++ + +A + EIE+L KL+HP ++ + F
Sbjct: 234 VKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFD 293
Query: 396 RRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCEN 455
Y+I + ME G+L + V+ ++E +++ Q+ LA+QY+HE I HRD+K EN
Sbjct: 294 AE-DYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPEN 352
Query: 456 VLLTANQN---VKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEIL--QGTPYLPKPT 510
VLL++ + +K++DFG +++ + L T CG+ +Y APE+L GT +
Sbjct: 353 VLLSSQEEDCLIKITDFGHSKILGETSL----MRTLCGTPTYLAPEVLVSVGTAGYNRAV 408
Query: 511 DVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINK-NWKFRSRYIDTISDNCKRLIGLMLE 569
D WSLG+++++ L+ PF + + + QI + F +S+ L+ +L
Sbjct: 409 DCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLV 468
Query: 570 PNHQNRLKIYDIVNSEWI 587
+ + R + + W+
Sbjct: 469 VDPKARFTTEEALRHPWL 486
>AF096279-1|AAD11784.1| 543|Homo sapiens HuCds1 kinase protein.
Length = 543
Score = 130 bits (313), Expect = 2e-29
Identities = 89/273 (32%), Positives = 140/273 (51%), Gaps = 14/273 (5%)
Query: 19 YKLTKFVGEGAYAKVYLT--EYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLV 76
Y ++K +G GA +V L + K+ + K K + D + + EI++L
Sbjct: 220 YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALN-VETEIEILK 278
Query: 77 RLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQY 136
+LNHP +I + + F + YYI + E G+L ++ N + E +++ Q+ L +QY
Sbjct: 279 KLNHPCIIKIKNFFDAED-YYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQY 337
Query: 137 LHELEIAHRDIKCENVLLTANFN---VKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAP 193
LHE I HRD+K ENVLL++ +K++DFG S+ E+ L T CG+ +Y AP
Sbjct: 338 LHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS----LMRTLCGTPTYLAP 393
Query: 194 EIL--RGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMR-KLYEQQMGKKYRFRSRVAS 250
E+L G + D WSLGV+LF+ L+ PF + R + L +Q KY F V +
Sbjct: 394 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 453
Query: 251 ILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+S + +VK LL DP R + L W+
Sbjct: 454 EVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 486
Score = 112 bits (269), Expect = 4e-24
Identities = 72/258 (27%), Positives = 130/258 (50%), Gaps = 11/258 (4%)
Query: 336 VYLAEYRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQ 395
V LA R K + I++ + +A + EIE+L KL+HP ++ + F
Sbjct: 234 VKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFD 293
Query: 396 RRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCEN 455
Y+I + ME G+L + V+ ++E +++ Q+ LA+QY+HE I HRD+K EN
Sbjct: 294 AE-DYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPEN 352
Query: 456 VLLTANQN---VKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEIL--QGTPYLPKPT 510
VLL++ + +K++DFG +++ + L T CG+ +Y APE+L GT +
Sbjct: 353 VLLSSQEEDCLIKITDFGHSKILGETSL----MRTLCGTPTYLAPEVLVSVGTAGYNRAV 408
Query: 511 DVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINK-NWKFRSRYIDTISDNCKRLIGLMLE 569
D WSLG+++++ L+ PF + + + QI + F +S+ L+ +L
Sbjct: 409 DCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLV 468
Query: 570 PNHQNRLKIYDIVNSEWI 587
+ + R + + W+
Sbjct: 469 VDPKARFTTEEALRHPWL 486
>AF086904-1|AAC83693.1| 543|Homo sapiens protein kinase Chk2
protein.
Length = 543
Score = 130 bits (313), Expect = 2e-29
Identities = 89/273 (32%), Positives = 140/273 (51%), Gaps = 14/273 (5%)
Query: 19 YKLTKFVGEGAYAKVYLT--EYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLV 76
Y ++K +G GA +V L + K+ + K K + D + + EI++L
Sbjct: 220 YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALN-VETEIEILK 278
Query: 77 RLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQY 136
+LNHP +I + + F + YYI + E G+L ++ N + E +++ Q+ L +QY
Sbjct: 279 KLNHPCIIKIKNFFDAED-YYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQY 337
Query: 137 LHELEIAHRDIKCENVLLTANFN---VKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAP 193
LHE I HRD+K ENVLL++ +K++DFG S+ E+ L T CG+ +Y AP
Sbjct: 338 LHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS----LMRTLCGTPTYLAP 393
Query: 194 EIL--RGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMR-KLYEQQMGKKYRFRSRVAS 250
E+L G + D WSLGV+LF+ L+ PF + R + L +Q KY F V +
Sbjct: 394 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 453
Query: 251 ILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
+S + +VK LL DP R + L W+
Sbjct: 454 EVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 486
Score = 112 bits (269), Expect = 4e-24
Identities = 72/258 (27%), Positives = 130/258 (50%), Gaps = 11/258 (4%)
Query: 336 VYLAEYRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQ 395
V LA R K + I++ + +A + EIE+L KL+HP ++ + F
Sbjct: 234 VKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFD 293
Query: 396 RRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCEN 455
Y+I + ME G+L + V+ ++E +++ Q+ LA+QY+HE I HRD+K EN
Sbjct: 294 AE-DYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPEN 352
Query: 456 VLLTANQN---VKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEIL--QGTPYLPKPT 510
VLL++ + +K++DFG +++ + L T CG+ +Y APE+L GT +
Sbjct: 353 VLLSSQEEDCLIKITDFGHSKILGETSL----MRTLCGTPTYLAPEVLVSVGTAGYNRAV 408
Query: 511 DVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINK-NWKFRSRYIDTISDNCKRLIGLMLE 569
D WSLG+++++ L+ PF + + + QI + F +S+ L+ +L
Sbjct: 409 DCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLV 468
Query: 570 PNHQNRLKIYDIVNSEWI 587
+ + R + + W+
Sbjct: 469 VDPKARFTTEEALRHPWL 486
>AF217975-1|AAG17218.1| 322|Homo sapiens unknown protein.
Length = 322
Score = 129 bits (312), Expect = 3e-29
Identities = 78/219 (35%), Positives = 119/219 (54%), Gaps = 11/219 (5%)
Query: 71 EIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQL 130
EI++L +LNHP +I + + F + YYI + E G+L ++ N + E +++ Q+
Sbjct: 52 EIEILKKLNHPCIIKIKNFFDAED-YYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQM 110
Query: 131 ALGLQYLHELEIAHRDIKCENVLLTANFN---VKLSDFGFSRFCVESDNQPVLSETYCGS 187
L +QYLHE I HRD+K ENVLL++ +K++DFG S+ E+ L T CG+
Sbjct: 111 LLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS----LMRTLCGT 166
Query: 188 MSYAAPEIL--RGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMR-KLYEQQMGKKYRF 244
+Y APE+L G + D WSLGV+LF+ L+ PF + R + L +Q KY F
Sbjct: 167 PTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNF 226
Query: 245 RSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWI 283
V + +S + +VK LL DP R + L W+
Sbjct: 227 IPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 265
Score = 112 bits (269), Expect = 4e-24
Identities = 72/258 (27%), Positives = 130/258 (50%), Gaps = 11/258 (4%)
Query: 336 VYLAEYRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQ 395
V LA R K + I++ + +A + EIE+L KL+HP ++ + F
Sbjct: 13 VKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFD 72
Query: 396 RRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCEN 455
Y+I + ME G+L + V+ ++E +++ Q+ LA+QY+HE I HRD+K EN
Sbjct: 73 AE-DYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPEN 131
Query: 456 VLLTANQN---VKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEIL--QGTPYLPKPT 510
VLL++ + +K++DFG +++ + L T CG+ +Y APE+L GT +
Sbjct: 132 VLLSSQEEDCLIKITDFGHSKILGETSL----MRTLCGTPTYLAPEVLVSVGTAGYNRAV 187
Query: 511 DVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINK-NWKFRSRYIDTISDNCKRLIGLMLE 569
D WSLG+++++ L+ PF + + + QI + F +S+ L+ +L
Sbjct: 188 DCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLV 247
Query: 570 PNHQNRLKIYDIVNSEWI 587
+ + R + + W+
Sbjct: 248 VDPKARFTTEEALRHPWL 265
>U66064-1|AAB80848.1| 315|Homo sapiens calcium/calmodulin-dependent
protein kinase II protein.
Length = 315
Score = 128 bits (310), Expect = 5e-29
Identities = 88/302 (29%), Positives = 142/302 (47%), Gaps = 13/302 (4%)
Query: 13 TLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREI 72
T T Y+L + +G+GA++ V + + A KII T K K L RE
Sbjct: 8 TRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEY----AAKIINTKKLSARDHQK-LEREA 62
Query: 73 DVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLAL 132
+ L HP+++ +H + +Y+ G+L I+ SE A Q+
Sbjct: 63 RICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILE 122
Query: 133 GLQYLHELEIAHRDIKCENVLLTANFN---VKLSDFGFSRFCVESDNQPVLSETYCGSMS 189
+ ++H+ +I HRD+K EN+LL + VKL+DFG + +E + + G+
Sbjct: 123 SVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLA---IEVQGEQQAWFGFAGTPG 179
Query: 190 YAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVA 249
Y +PE+LR PY KP D+W+ GV+L+++L PF D KLY+Q Y F S
Sbjct: 180 YLSPEVLRKDPY-GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEW 238
Query: 250 SILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRLTT-LNAVEAAALKRAKEDRR 308
++ E K ++ +L +P R +A L W+ S + + ++ E R RR
Sbjct: 239 DTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARR 298
Query: 309 KL 310
KL
Sbjct: 299 KL 300
Score = 117 bits (282), Expect = 1e-25
Identities = 85/288 (29%), Positives = 138/288 (47%), Gaps = 13/288 (4%)
Query: 342 RNASKNDKLSILACKVIDTST-APRDFVKKFLPREIEMLIKLSHPHLVHTH-SIFQRRYK 399
R K A K+I+T + RD K L RE + L HP++V H SI + +
Sbjct: 29 RRCVKKTSTQEYAAKIINTKKLSARDHQK--LEREARICRLLKHPNIVRLHDSISEEGFH 86
Query: 400 YFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLT 459
Y +F + G+L E ++ R E A Q+ ++ ++H+ +I HRD+K EN+LL
Sbjct: 87 YLVF-DLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLA 145
Query: 460 A---NQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLG 516
+ VKL+DFG A ++ + + F G+ Y +PE+L+ PY KP D+W+ G
Sbjct: 146 SKCKGAAVKLADFGLA---IEVQGEQQAWFGFAGTPGYLSPEVLRKDPY-GKPVDIWACG 201
Query: 517 IVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRL 576
+++Y++L PF D+ +L+Q + F S DT++ K LI ML N R+
Sbjct: 202 VILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRI 261
Query: 577 KIYDIVNSEWIAMDSRLLEWT-PQETLAYKKAREEKNKLHKTVETVEL 623
+ W+ S + QET+ + + KL + T L
Sbjct: 262 TADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTML 309
>AL713896-5|CAI13788.1| 516|Homo sapiens
calcium/calmodulin-dependent protein kinase (CaM kinase)
II gamma protein.
Length = 516
Score = 128 bits (310), Expect = 5e-29
Identities = 88/302 (29%), Positives = 142/302 (47%), Gaps = 13/302 (4%)
Query: 13 TLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREI 72
T T Y+L + +G+GA++ V + + A KII T K K L RE
Sbjct: 8 TRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEY----AAKIINTKKLSARDHQK-LEREA 62
Query: 73 DVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLAL 132
+ L HP+++ +H + +Y+ G+L I+ SE A Q+
Sbjct: 63 RICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILE 122
Query: 133 GLQYLHELEIAHRDIKCENVLLTANFN---VKLSDFGFSRFCVESDNQPVLSETYCGSMS 189
+ ++H+ +I HRD+K EN+LL + VKL+DFG + +E + + G+
Sbjct: 123 SVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLA---IEVQGEQQAWFGFAGTPG 179
Query: 190 YAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVA 249
Y +PE+LR PY KP D+W+ GV+L+++L PF D KLY+Q Y F S
Sbjct: 180 YLSPEVLRKDPY-GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEW 238
Query: 250 SILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRLTT-LNAVEAAALKRAKEDRR 308
++ E K ++ +L +P R +A L W+ S + + ++ E R RR
Sbjct: 239 DTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARR 298
Query: 309 KL 310
KL
Sbjct: 299 KL 300
Score = 117 bits (282), Expect = 1e-25
Identities = 85/288 (29%), Positives = 138/288 (47%), Gaps = 13/288 (4%)
Query: 342 RNASKNDKLSILACKVIDTST-APRDFVKKFLPREIEMLIKLSHPHLVHTH-SIFQRRYK 399
R K A K+I+T + RD K L RE + L HP++V H SI + +
Sbjct: 29 RRCVKKTSTQEYAAKIINTKKLSARDHQK--LEREARICRLLKHPNIVRLHDSISEEGFH 86
Query: 400 YFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLT 459
Y +F + G+L E ++ R E A Q+ ++ ++H+ +I HRD+K EN+LL
Sbjct: 87 YLVF-DLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLA 145
Query: 460 A---NQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLG 516
+ VKL+DFG A ++ + + F G+ Y +PE+L+ PY KP D+W+ G
Sbjct: 146 SKCKGAAVKLADFGLA---IEVQGEQQAWFGFAGTPGYLSPEVLRKDPY-GKPVDIWACG 201
Query: 517 IVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRL 576
+++Y++L PF D+ +L+Q + F S DT++ K LI ML N R+
Sbjct: 202 VILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRI 261
Query: 577 KIYDIVNSEWIAMDSRLLEWT-PQETLAYKKAREEKNKLHKTVETVEL 623
+ W+ S + QET+ + + KL + T L
Sbjct: 262 TADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTML 309
>AL713896-4|CAI13789.1| 495|Homo sapiens
calcium/calmodulin-dependent protein kinase (CaM kinase)
II gamma protein.
Length = 495
Score = 128 bits (310), Expect = 5e-29
Identities = 88/302 (29%), Positives = 142/302 (47%), Gaps = 13/302 (4%)
Query: 13 TLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREI 72
T T Y+L + +G+GA++ V + + A KII T K K L RE
Sbjct: 8 TRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEY----AAKIINTKKLSARDHQK-LEREA 62
Query: 73 DVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLAL 132
+ L HP+++ +H + +Y+ G+L I+ SE A Q+
Sbjct: 63 RICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILE 122
Query: 133 GLQYLHELEIAHRDIKCENVLLTANFN---VKLSDFGFSRFCVESDNQPVLSETYCGSMS 189
+ ++H+ +I HRD+K EN+LL + VKL+DFG + +E + + G+
Sbjct: 123 SVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLA---IEVQGEQQAWFGFAGTPG 179
Query: 190 YAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVA 249
Y +PE+LR PY KP D+W+ GV+L+++L PF D KLY+Q Y F S
Sbjct: 180 YLSPEVLRKDPY-GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEW 238
Query: 250 SILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRLTT-LNAVEAAALKRAKEDRR 308
++ E K ++ +L +P R +A L W+ S + + ++ E R RR
Sbjct: 239 DTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARR 298
Query: 309 KL 310
KL
Sbjct: 299 KL 300
Score = 117 bits (282), Expect = 1e-25
Identities = 85/288 (29%), Positives = 138/288 (47%), Gaps = 13/288 (4%)
Query: 342 RNASKNDKLSILACKVIDTST-APRDFVKKFLPREIEMLIKLSHPHLVHTH-SIFQRRYK 399
R K A K+I+T + RD K L RE + L HP++V H SI + +
Sbjct: 29 RRCVKKTSTQEYAAKIINTKKLSARDHQK--LEREARICRLLKHPNIVRLHDSISEEGFH 86
Query: 400 YFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLT 459
Y +F + G+L E ++ R E A Q+ ++ ++H+ +I HRD+K EN+LL
Sbjct: 87 YLVF-DLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLA 145
Query: 460 A---NQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLG 516
+ VKL+DFG A ++ + + F G+ Y +PE+L+ PY KP D+W+ G
Sbjct: 146 SKCKGAAVKLADFGLA---IEVQGEQQAWFGFAGTPGYLSPEVLRKDPY-GKPVDIWACG 201
Query: 517 IVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRL 576
+++Y++L PF D+ +L+Q + F S DT++ K LI ML N R+
Sbjct: 202 VILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRI 261
Query: 577 KIYDIVNSEWIAMDSRLLEWT-PQETLAYKKAREEKNKLHKTVETVEL 623
+ W+ S + QET+ + + KL + T L
Sbjct: 262 TADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTML 309
>AL713896-3|CAI13790.1| 529|Homo sapiens
calcium/calmodulin-dependent protein kinase (CaM kinase)
II gamma protein.
Length = 529
Score = 128 bits (310), Expect = 5e-29
Identities = 88/302 (29%), Positives = 142/302 (47%), Gaps = 13/302 (4%)
Query: 13 TLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREI 72
T T Y+L + +G+GA++ V + + A KII T K K L RE
Sbjct: 8 TRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEY----AAKIINTKKLSARDHQK-LEREA 62
Query: 73 DVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLAL 132
+ L HP+++ +H + +Y+ G+L I+ SE A Q+
Sbjct: 63 RICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILE 122
Query: 133 GLQYLHELEIAHRDIKCENVLLTANFN---VKLSDFGFSRFCVESDNQPVLSETYCGSMS 189
+ ++H+ +I HRD+K EN+LL + VKL+DFG + +E + + G+
Sbjct: 123 SVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLA---IEVQGEQQAWFGFAGTPG 179
Query: 190 YAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVA 249
Y +PE+LR PY KP D+W+ GV+L+++L PF D KLY+Q Y F S
Sbjct: 180 YLSPEVLRKDPY-GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEW 238
Query: 250 SILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRLTT-LNAVEAAALKRAKEDRR 308
++ E K ++ +L +P R +A L W+ S + + ++ E R RR
Sbjct: 239 DTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARR 298
Query: 309 KL 310
KL
Sbjct: 299 KL 300
Score = 117 bits (282), Expect = 1e-25
Identities = 85/288 (29%), Positives = 138/288 (47%), Gaps = 13/288 (4%)
Query: 342 RNASKNDKLSILACKVIDTST-APRDFVKKFLPREIEMLIKLSHPHLVHTH-SIFQRRYK 399
R K A K+I+T + RD K L RE + L HP++V H SI + +
Sbjct: 29 RRCVKKTSTQEYAAKIINTKKLSARDHQK--LEREARICRLLKHPNIVRLHDSISEEGFH 86
Query: 400 YFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLT 459
Y +F + G+L E ++ R E A Q+ ++ ++H+ +I HRD+K EN+LL
Sbjct: 87 YLVF-DLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLA 145
Query: 460 A---NQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLG 516
+ VKL+DFG A ++ + + F G+ Y +PE+L+ PY KP D+W+ G
Sbjct: 146 SKCKGAAVKLADFGLA---IEVQGEQQAWFGFAGTPGYLSPEVLRKDPY-GKPVDIWACG 201
Query: 517 IVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRL 576
+++Y++L PF D+ +L+Q + F S DT++ K LI ML N R+
Sbjct: 202 VILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRI 261
Query: 577 KIYDIVNSEWIAMDSRLLEWT-PQETLAYKKAREEKNKLHKTVETVEL 623
+ W+ S + QET+ + + KL + T L
Sbjct: 262 TADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTML 309
>AL713896-2|CAI13791.1| 527|Homo sapiens
calcium/calmodulin-dependent protein kinase (CaM kinase)
II gamma protein.
Length = 527
Score = 128 bits (310), Expect = 5e-29
Identities = 88/302 (29%), Positives = 142/302 (47%), Gaps = 13/302 (4%)
Query: 13 TLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREI 72
T T Y+L + +G+GA++ V + + A KII T K K L RE
Sbjct: 8 TRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEY----AAKIINTKKLSARDHQK-LEREA 62
Query: 73 DVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLAL 132
+ L HP+++ +H + +Y+ G+L I+ SE A Q+
Sbjct: 63 RICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILE 122
Query: 133 GLQYLHELEIAHRDIKCENVLLTANFN---VKLSDFGFSRFCVESDNQPVLSETYCGSMS 189
+ ++H+ +I HRD+K EN+LL + VKL+DFG + +E + + G+
Sbjct: 123 SVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLA---IEVQGEQQAWFGFAGTPG 179
Query: 190 YAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVA 249
Y +PE+LR PY KP D+W+ GV+L+++L PF D KLY+Q Y F S
Sbjct: 180 YLSPEVLRKDPY-GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEW 238
Query: 250 SILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRLTT-LNAVEAAALKRAKEDRR 308
++ E K ++ +L +P R +A L W+ S + + ++ E R RR
Sbjct: 239 DTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARR 298
Query: 309 KL 310
KL
Sbjct: 299 KL 300
Score = 117 bits (282), Expect = 1e-25
Identities = 85/288 (29%), Positives = 138/288 (47%), Gaps = 13/288 (4%)
Query: 342 RNASKNDKLSILACKVIDTST-APRDFVKKFLPREIEMLIKLSHPHLVHTH-SIFQRRYK 399
R K A K+I+T + RD K L RE + L HP++V H SI + +
Sbjct: 29 RRCVKKTSTQEYAAKIINTKKLSARDHQK--LEREARICRLLKHPNIVRLHDSISEEGFH 86
Query: 400 YFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLT 459
Y +F + G+L E ++ R E A Q+ ++ ++H+ +I HRD+K EN+LL
Sbjct: 87 YLVF-DLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLA 145
Query: 460 A---NQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLG 516
+ VKL+DFG A ++ + + F G+ Y +PE+L+ PY KP D+W+ G
Sbjct: 146 SKCKGAAVKLADFGLA---IEVQGEQQAWFGFAGTPGYLSPEVLRKDPY-GKPVDIWACG 201
Query: 517 IVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRL 576
+++Y++L PF D+ +L+Q + F S DT++ K LI ML N R+
Sbjct: 202 VILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRI 261
Query: 577 KIYDIVNSEWIAMDSRLLEWT-PQETLAYKKAREEKNKLHKTVETVEL 623
+ W+ S + QET+ + + KL + T L
Sbjct: 262 TADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTML 309
>AL596247-5|CAI13967.1| 516|Homo sapiens
calcium/calmodulin-dependent protein kinase (CaM kinase)
II gamma protein.
Length = 516
Score = 128 bits (310), Expect = 5e-29
Identities = 88/302 (29%), Positives = 142/302 (47%), Gaps = 13/302 (4%)
Query: 13 TLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREI 72
T T Y+L + +G+GA++ V + + A KII T K K L RE
Sbjct: 8 TRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEY----AAKIINTKKLSARDHQK-LEREA 62
Query: 73 DVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLAL 132
+ L HP+++ +H + +Y+ G+L I+ SE A Q+
Sbjct: 63 RICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILE 122
Query: 133 GLQYLHELEIAHRDIKCENVLLTANFN---VKLSDFGFSRFCVESDNQPVLSETYCGSMS 189
+ ++H+ +I HRD+K EN+LL + VKL+DFG + +E + + G+
Sbjct: 123 SVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLA---IEVQGEQQAWFGFAGTPG 179
Query: 190 YAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVA 249
Y +PE+LR PY KP D+W+ GV+L+++L PF D KLY+Q Y F S
Sbjct: 180 YLSPEVLRKDPY-GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEW 238
Query: 250 SILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRLTT-LNAVEAAALKRAKEDRR 308
++ E K ++ +L +P R +A L W+ S + + ++ E R RR
Sbjct: 239 DTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARR 298
Query: 309 KL 310
KL
Sbjct: 299 KL 300
Score = 117 bits (282), Expect = 1e-25
Identities = 85/288 (29%), Positives = 138/288 (47%), Gaps = 13/288 (4%)
Query: 342 RNASKNDKLSILACKVIDTST-APRDFVKKFLPREIEMLIKLSHPHLVHTH-SIFQRRYK 399
R K A K+I+T + RD K L RE + L HP++V H SI + +
Sbjct: 29 RRCVKKTSTQEYAAKIINTKKLSARDHQK--LEREARICRLLKHPNIVRLHDSISEEGFH 86
Query: 400 YFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLT 459
Y +F + G+L E ++ R E A Q+ ++ ++H+ +I HRD+K EN+LL
Sbjct: 87 YLVF-DLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLA 145
Query: 460 A---NQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLG 516
+ VKL+DFG A ++ + + F G+ Y +PE+L+ PY KP D+W+ G
Sbjct: 146 SKCKGAAVKLADFGLA---IEVQGEQQAWFGFAGTPGYLSPEVLRKDPY-GKPVDIWACG 201
Query: 517 IVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRL 576
+++Y++L PF D+ +L+Q + F S DT++ K LI ML N R+
Sbjct: 202 VILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRI 261
Query: 577 KIYDIVNSEWIAMDSRLLEWT-PQETLAYKKAREEKNKLHKTVETVEL 623
+ W+ S + QET+ + + KL + T L
Sbjct: 262 TADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTML 309
>AL596247-4|CAI13966.1| 495|Homo sapiens
calcium/calmodulin-dependent protein kinase (CaM kinase)
II gamma protein.
Length = 495
Score = 128 bits (310), Expect = 5e-29
Identities = 88/302 (29%), Positives = 142/302 (47%), Gaps = 13/302 (4%)
Query: 13 TLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREI 72
T T Y+L + +G+GA++ V + + A KII T K K L RE
Sbjct: 8 TRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEY----AAKIINTKKLSARDHQK-LEREA 62
Query: 73 DVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLAL 132
+ L HP+++ +H + +Y+ G+L I+ SE A Q+
Sbjct: 63 RICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILE 122
Query: 133 GLQYLHELEIAHRDIKCENVLLTANFN---VKLSDFGFSRFCVESDNQPVLSETYCGSMS 189
+ ++H+ +I HRD+K EN+LL + VKL+DFG + +E + + G+
Sbjct: 123 SVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLA---IEVQGEQQAWFGFAGTPG 179
Query: 190 YAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVA 249
Y +PE+LR PY KP D+W+ GV+L+++L PF D KLY+Q Y F S
Sbjct: 180 YLSPEVLRKDPY-GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEW 238
Query: 250 SILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRLTT-LNAVEAAALKRAKEDRR 308
++ E K ++ +L +P R +A L W+ S + + ++ E R RR
Sbjct: 239 DTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARR 298
Query: 309 KL 310
KL
Sbjct: 299 KL 300
Score = 117 bits (282), Expect = 1e-25
Identities = 85/288 (29%), Positives = 138/288 (47%), Gaps = 13/288 (4%)
Query: 342 RNASKNDKLSILACKVIDTST-APRDFVKKFLPREIEMLIKLSHPHLVHTH-SIFQRRYK 399
R K A K+I+T + RD K L RE + L HP++V H SI + +
Sbjct: 29 RRCVKKTSTQEYAAKIINTKKLSARDHQK--LEREARICRLLKHPNIVRLHDSISEEGFH 86
Query: 400 YFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLT 459
Y +F + G+L E ++ R E A Q+ ++ ++H+ +I HRD+K EN+LL
Sbjct: 87 YLVF-DLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLA 145
Query: 460 A---NQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLG 516
+ VKL+DFG A ++ + + F G+ Y +PE+L+ PY KP D+W+ G
Sbjct: 146 SKCKGAAVKLADFGLA---IEVQGEQQAWFGFAGTPGYLSPEVLRKDPY-GKPVDIWACG 201
Query: 517 IVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRL 576
+++Y++L PF D+ +L+Q + F S DT++ K LI ML N R+
Sbjct: 202 VILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRI 261
Query: 577 KIYDIVNSEWIAMDSRLLEWT-PQETLAYKKAREEKNKLHKTVETVEL 623
+ W+ S + QET+ + + KL + T L
Sbjct: 262 TADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTML 309
>AL596247-3|CAI13965.1| 529|Homo sapiens
calcium/calmodulin-dependent protein kinase (CaM kinase)
II gamma protein.
Length = 529
Score = 128 bits (310), Expect = 5e-29
Identities = 88/302 (29%), Positives = 142/302 (47%), Gaps = 13/302 (4%)
Query: 13 TLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREI 72
T T Y+L + +G+GA++ V + + A KII T K K L RE
Sbjct: 8 TRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEY----AAKIINTKKLSARDHQK-LEREA 62
Query: 73 DVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLAL 132
+ L HP+++ +H + +Y+ G+L I+ SE A Q+
Sbjct: 63 RICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILE 122
Query: 133 GLQYLHELEIAHRDIKCENVLLTANFN---VKLSDFGFSRFCVESDNQPVLSETYCGSMS 189
+ ++H+ +I HRD+K EN+LL + VKL+DFG + +E + + G+
Sbjct: 123 SVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLA---IEVQGEQQAWFGFAGTPG 179
Query: 190 YAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVA 249
Y +PE+LR PY KP D+W+ GV+L+++L PF D KLY+Q Y F S
Sbjct: 180 YLSPEVLRKDPY-GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEW 238
Query: 250 SILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRLTT-LNAVEAAALKRAKEDRR 308
++ E K ++ +L +P R +A L W+ S + + ++ E R RR
Sbjct: 239 DTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARR 298
Query: 309 KL 310
KL
Sbjct: 299 KL 300
Score = 117 bits (282), Expect = 1e-25
Identities = 85/288 (29%), Positives = 138/288 (47%), Gaps = 13/288 (4%)
Query: 342 RNASKNDKLSILACKVIDTST-APRDFVKKFLPREIEMLIKLSHPHLVHTH-SIFQRRYK 399
R K A K+I+T + RD K L RE + L HP++V H SI + +
Sbjct: 29 RRCVKKTSTQEYAAKIINTKKLSARDHQK--LEREARICRLLKHPNIVRLHDSISEEGFH 86
Query: 400 YFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLT 459
Y +F + G+L E ++ R E A Q+ ++ ++H+ +I HRD+K EN+LL
Sbjct: 87 YLVF-DLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLA 145
Query: 460 A---NQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLG 516
+ VKL+DFG A ++ + + F G+ Y +PE+L+ PY KP D+W+ G
Sbjct: 146 SKCKGAAVKLADFGLA---IEVQGEQQAWFGFAGTPGYLSPEVLRKDPY-GKPVDIWACG 201
Query: 517 IVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRL 576
+++Y++L PF D+ +L+Q + F S DT++ K LI ML N R+
Sbjct: 202 VILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRI 261
Query: 577 KIYDIVNSEWIAMDSRLLEWT-PQETLAYKKAREEKNKLHKTVETVEL 623
+ W+ S + QET+ + + KL + T L
Sbjct: 262 TADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTML 309
>AL596247-2|CAI13968.1| 527|Homo sapiens
calcium/calmodulin-dependent protein kinase (CaM kinase)
II gamma protein.
Length = 527
Score = 128 bits (310), Expect = 5e-29
Identities = 88/302 (29%), Positives = 142/302 (47%), Gaps = 13/302 (4%)
Query: 13 TLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREI 72
T T Y+L + +G+GA++ V + + A KII T K K L RE
Sbjct: 8 TRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEY----AAKIINTKKLSARDHQK-LEREA 62
Query: 73 DVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLAL 132
+ L HP+++ +H + +Y+ G+L I+ SE A Q+
Sbjct: 63 RICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILE 122
Query: 133 GLQYLHELEIAHRDIKCENVLLTANFN---VKLSDFGFSRFCVESDNQPVLSETYCGSMS 189
+ ++H+ +I HRD+K EN+LL + VKL+DFG + +E + + G+
Sbjct: 123 SVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLA---IEVQGEQQAWFGFAGTPG 179
Query: 190 YAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVA 249
Y +PE+LR PY KP D+W+ GV+L+++L PF D KLY+Q Y F S
Sbjct: 180 YLSPEVLRKDPY-GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEW 238
Query: 250 SILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRLTT-LNAVEAAALKRAKEDRR 308
++ E K ++ +L +P R +A L W+ S + + ++ E R RR
Sbjct: 239 DTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARR 298
Query: 309 KL 310
KL
Sbjct: 299 KL 300
Score = 117 bits (282), Expect = 1e-25
Identities = 85/288 (29%), Positives = 138/288 (47%), Gaps = 13/288 (4%)
Query: 342 RNASKNDKLSILACKVIDTST-APRDFVKKFLPREIEMLIKLSHPHLVHTH-SIFQRRYK 399
R K A K+I+T + RD K L RE + L HP++V H SI + +
Sbjct: 29 RRCVKKTSTQEYAAKIINTKKLSARDHQK--LEREARICRLLKHPNIVRLHDSISEEGFH 86
Query: 400 YFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLT 459
Y +F + G+L E ++ R E A Q+ ++ ++H+ +I HRD+K EN+LL
Sbjct: 87 YLVF-DLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLA 145
Query: 460 A---NQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLG 516
+ VKL+DFG A ++ + + F G+ Y +PE+L+ PY KP D+W+ G
Sbjct: 146 SKCKGAAVKLADFGLA---IEVQGEQQAWFGFAGTPGYLSPEVLRKDPY-GKPVDIWACG 201
Query: 517 IVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRL 576
+++Y++L PF D+ +L+Q + F S DT++ K LI ML N R+
Sbjct: 202 VILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRI 261
Query: 577 KIYDIVNSEWIAMDSRLLEWT-PQETLAYKKAREEKNKLHKTVETVEL 623
+ W+ S + QET+ + + KL + T L
Sbjct: 262 TADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTML 309
>BC047896-1|AAH47896.1| 524|Homo sapiens RPS6KA4 protein protein.
Length = 524
Score = 128 bits (309), Expect = 6e-29
Identities = 74/228 (32%), Positives = 124/228 (54%), Gaps = 8/228 (3%)
Query: 1 MTDLKTTPSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETA--- 57
+T+ T EE + + ++L K +G GAY KV+L + D+ K A K++ A
Sbjct: 16 ITEANLTGHEEKVSV-ENFELLKVLGTGAYGKVFLVRKAGGHDAGK-LYAMKVLRKAALV 73
Query: 58 KAPKDFVVKFLPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGC 117
+ K R + LVR P L+ +H FQ K ++ + Y G++ +++ +
Sbjct: 74 QRAKTQEHTRTERSVLELVR-QAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQY 132
Query: 118 VSENQARVWTRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQ 177
E + RV+ ++ L L++LH+L I +RD+K ENVLL + ++ L+DFG S+ + + +
Sbjct: 133 FKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKE 192
Query: 178 PVLSETYCGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPF 225
S +CG++ Y APEI+R K K D WSLG++LF +L + PF
Sbjct: 193 RTFS--FCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPF 238
Score = 104 bits (249), Expect = 1e-21
Identities = 50/145 (34%), Positives = 89/145 (61%), Gaps = 2/145 (1%)
Query: 385 PHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHEL 444
P LV H FQ K + + Y+ G++ + QR +E + R++ ++ LA++++H+L
Sbjct: 96 PFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKL 155
Query: 445 EIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTP 504
I +RD+K ENVLL + ++ L+DFG ++ + ++ + R+ +FCG++ Y APEI++
Sbjct: 156 GIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEE--KERTFSFCGTIEYMAPEIIRSKT 213
Query: 505 YLPKPTDVWSLGIVVYVMLNRAMPF 529
K D WSLGI+++ +L A PF
Sbjct: 214 GHGKAVDWWSLGILLFELLTGASPF 238
>BC034044-1|AAH34044.1| 527|Homo sapiens
calcium/calmodulin-dependent protein kinase (CaM kinase)
II gamma protein.
Length = 527
Score = 128 bits (309), Expect = 6e-29
Identities = 88/302 (29%), Positives = 142/302 (47%), Gaps = 13/302 (4%)
Query: 13 TLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREI 72
T T Y+L + +G+GA++ V + + A KII T K K L RE
Sbjct: 8 TRFTDDYQLFEELGKGAFSVVRRCVKKTPTQEY----AAKIINTKKLSARDHQK-LEREA 62
Query: 73 DVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLAL 132
+ L HP+++ +H + +Y+ G+L I+ SE A Q+
Sbjct: 63 RICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILE 122
Query: 133 GLQYLHELEIAHRDIKCENVLLTANFN---VKLSDFGFSRFCVESDNQPVLSETYCGSMS 189
+ ++H+ +I HRD+K EN+LL + VKL+DFG + +E + + G+
Sbjct: 123 SVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLA---IEVQGEQQAWFGFAGTPG 179
Query: 190 YAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVA 249
Y +PE+LR PY KP D+W+ GV+L+++L PF D KLY+Q Y F S
Sbjct: 180 YLSPEVLRKDPY-GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEW 238
Query: 250 SILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRLTT-LNAVEAAALKRAKEDRR 308
++ E K ++ +L +P R +A L W+ S + + ++ E R RR
Sbjct: 239 DTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARR 298
Query: 309 KL 310
KL
Sbjct: 299 KL 300
Score = 117 bits (281), Expect = 2e-25
Identities = 85/288 (29%), Positives = 138/288 (47%), Gaps = 13/288 (4%)
Query: 342 RNASKNDKLSILACKVIDTST-APRDFVKKFLPREIEMLIKLSHPHLVHTH-SIFQRRYK 399
R K A K+I+T + RD K L RE + L HP++V H SI + +
Sbjct: 29 RRCVKKTPTQEYAAKIINTKKLSARDHQK--LEREARICRLLKHPNIVRLHDSISEEGFH 86
Query: 400 YFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLT 459
Y +F + G+L E ++ R E A Q+ ++ ++H+ +I HRD+K EN+LL
Sbjct: 87 YLVF-DLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLA 145
Query: 460 A---NQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLG 516
+ VKL+DFG A ++ + + F G+ Y +PE+L+ PY KP D+W+ G
Sbjct: 146 SKCKGAAVKLADFGLA---IEVQGEQQAWFGFAGTPGYLSPEVLRKDPY-GKPVDIWACG 201
Query: 517 IVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRL 576
+++Y++L PF D+ +L+Q + F S DT++ K LI ML N R+
Sbjct: 202 VILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRI 261
Query: 577 KIYDIVNSEWIAMDSRLLEWT-PQETLAYKKAREEKNKLHKTVETVEL 623
+ W+ S + QET+ + + KL + T L
Sbjct: 262 TADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTML 309
>BC028079-1|AAH28079.1| 556|Homo sapiens Unknown (protein for
IMAGE:5216639) protein.
Length = 556
Score = 128 bits (309), Expect = 6e-29
Identities = 74/228 (32%), Positives = 124/228 (54%), Gaps = 8/228 (3%)
Query: 1 MTDLKTTPSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETA--- 57
+T+ T EE + + ++L K +G GAY KV+L + D+ K A K++ A
Sbjct: 16 ITEANLTGHEEKVSV-ENFELLKVLGTGAYGKVFLVRKAGGHDAGK-LYAMKVLRKAALV 73
Query: 58 KAPKDFVVKFLPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGC 117
+ K R + LVR P L+ +H FQ K ++ + Y G++ +++ +
Sbjct: 74 QRAKTQEHTRTERSVLELVR-QAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQY 132
Query: 118 VSENQARVWTRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQ 177
E + RV+ ++ L L++LH+L I +RD+K ENVLL + ++ L+DFG S+ + + +
Sbjct: 133 FKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKE 192
Query: 178 PVLSETYCGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPF 225
S +CG++ Y APEI+R K K D WSLG++LF +L + PF
Sbjct: 193 RTFS--FCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPF 238
Score = 104 bits (249), Expect = 1e-21
Identities = 50/145 (34%), Positives = 89/145 (61%), Gaps = 2/145 (1%)
Query: 385 PHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHEL 444
P LV H FQ K + + Y+ G++ + QR +E + R++ ++ LA++++H+L
Sbjct: 96 PFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKL 155
Query: 445 EIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTP 504
I +RD+K ENVLL + ++ L+DFG ++ + ++ + R+ +FCG++ Y APEI++
Sbjct: 156 GIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEE--KERTFSFCGTIEYMAPEIIRSKT 213
Query: 505 YLPKPTDVWSLGIVVYVMLNRAMPF 529
K D WSLGI+++ +L A PF
Sbjct: 214 GHGKAVDWWSLGILLFELLTGASPF 238
Score = 64.9 bits (151), Expect = 9e-10
Identities = 39/132 (29%), Positives = 69/132 (52%), Gaps = 13/132 (9%)
Query: 51 CKIIETAKAPKDFVVKFLPREIDV-------LVRL--NHPHLIHVHSIFQRKTKYYIFMR 101
C+ ++ ++F VK L R ++ +RL +HP+++++H + + Y+ +
Sbjct: 425 CRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLE 484
Query: 102 YTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH-ELEIAHRDIKCENVLL---TAN 157
G+LL +I K SE++A R L + ++H E + HRD+K EN+L T
Sbjct: 485 LLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPG 544
Query: 158 FNVKLSDFGFSR 169
VK+ DFGF+R
Sbjct: 545 APVKIIDFGFAR 556
Score = 64.5 bits (150), Expect = 1e-09
Identities = 36/105 (34%), Positives = 58/105 (55%), Gaps = 5/105 (4%)
Query: 374 REIEML-IKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTR 432
RE+ L + SHP++V+ H + + ++ + + G+LLE + ++ E +A R
Sbjct: 452 REVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILR 511
Query: 433 QLALAIQYMH-ELEIAHRDIKCENVLL---TANQNVKLSDFGFAR 473
L A+ +MH E + HRD+K EN+L T VK+ DFGFAR
Sbjct: 512 SLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFAR 556
>AK223561-1|BAD97281.1| 765|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 4 isoform b variant protein.
Length = 765
Score = 128 bits (309), Expect = 6e-29
Identities = 74/228 (32%), Positives = 124/228 (54%), Gaps = 8/228 (3%)
Query: 1 MTDLKTTPSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETA--- 57
+T+ T EE + + ++L K +G GAY KV+L + D+ K A K++ A
Sbjct: 16 ITEANLTGHEEKVSV-ENFELLKVLGTGAYGKVFLVRKAGGHDAGK-LYAMKVLRKAALV 73
Query: 58 KAPKDFVVKFLPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGC 117
+ K R + LVR P L+ +H FQ K ++ + Y G++ +++ +
Sbjct: 74 QRAKTQEHTRTERSVLELVR-QAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQY 132
Query: 118 VSENQARVWTRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQ 177
E + RV+ ++ L L++LH+L I +RD+K ENVLL + ++ L+DFG S+ + + +
Sbjct: 133 FKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKE 192
Query: 178 PVLSETYCGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPF 225
S +CG++ Y APEI+R K K D WSLG++LF +L + PF
Sbjct: 193 RTFS--FCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPF 238
Score = 111 bits (266), Expect = 1e-23
Identities = 76/253 (30%), Positives = 127/253 (50%), Gaps = 23/253 (9%)
Query: 51 CKIIETAKAPKDFVVKFLPREIDV-------LVRL--NHPHLIHVHSIFQRKTKYYIFMR 101
C+ ++ ++F VK L R ++ +RL +HP+++++H + + Y+ +
Sbjct: 418 CRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQPHTYLVLE 477
Query: 102 YTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH-ELEIAHRDIKCENVLL---TAN 157
G+LL +I K SE++A R L + ++H E + HRD+K EN+L T
Sbjct: 478 LLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPG 537
Query: 158 FNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFV 217
VK+ DFGF+R +S P+ +T C ++ YAAPE+L + Y + DLWSLGV+L++
Sbjct: 538 APVKIIDFGFARLRPQSPGVPM--QTPCFTLQYAAPELLAQQGY-DESCDLWSLGVILYM 594
Query: 218 MLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASI-------LSLECKTVVKHLLEPDPGL 270
ML+ +PF + Q + R S+ +S E K +V+ LL DP
Sbjct: 595 MLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAK 654
Query: 271 RHSATNVLDSEWI 283
R + S W+
Sbjct: 655 RLKLEGLRGSSWL 667
Score = 104 bits (249), Expect = 1e-21
Identities = 50/145 (34%), Positives = 89/145 (61%), Gaps = 2/145 (1%)
Query: 385 PHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHEL 444
P LV H FQ K + + Y+ G++ + QR +E + R++ ++ LA++++H+L
Sbjct: 96 PFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKL 155
Query: 445 EIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTP 504
I +RD+K ENVLL + ++ L+DFG ++ + ++ + R+ +FCG++ Y APEI++
Sbjct: 156 GIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEE--KERTFSFCGTIEYMAPEIIRSKT 213
Query: 505 YLPKPTDVWSLGIVVYVMLNRAMPF 529
K D WSLGI+++ +L A PF
Sbjct: 214 GHGKAVDWWSLGILLFELLTGASPF 238
Score = 100 bits (239), Expect = 2e-20
Identities = 67/226 (29%), Positives = 115/226 (50%), Gaps = 15/226 (6%)
Query: 374 REIEML-IKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTR 432
RE+ L + SHP++V+ H + + ++ + + G+LLE + ++ E +A R
Sbjct: 445 REVAALRLCQSHPNVVNLHEVHHDQPHTYLVLELLRGGELLEHIRKKRHFSESEASQILR 504
Query: 433 QLALAIQYMH-ELEIAHRDIKCENVLL---TANQNVKLSDFGFARMCVDKKLNEIRSETF 488
L A+ +MH E + HRD+K EN+L T VK+ DFGFAR+ + + +T
Sbjct: 505 SLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARL--RPQSPGVPMQTP 562
Query: 489 CGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIK--QLHQAQI---- 542
C +L Y APE+L Y + D+WSLG+++Y+ML+ +PF+ + Q A+I
Sbjct: 563 CFTLQYAAPELLAQQGY-DESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKI 621
Query: 543 -NKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+ +S+ K L+ +L + RLK+ + S W+
Sbjct: 622 REGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRGSSWL 667
>AJ010119-1|CAA09009.1| 772|Homo sapiens Ribosomal protein kinase B
(RSK-B) protein.
Length = 772
Score = 128 bits (309), Expect = 6e-29
Identities = 74/228 (32%), Positives = 124/228 (54%), Gaps = 8/228 (3%)
Query: 1 MTDLKTTPSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETA--- 57
+T+ T EE + + ++L K +G GAY KV+L + D+ K A K++ A
Sbjct: 16 ITEANLTGHEEKVSV-ENFELLKVLGTGAYGKVFLVRKAGGHDAGK-LYAMKVLRKAALV 73
Query: 58 KAPKDFVVKFLPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGC 117
+ K R + LVR P L+ +H FQ K ++ + Y G++ +++ +
Sbjct: 74 QRAKTQEHTRTERSVLELVR-QAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQY 132
Query: 118 VSENQARVWTRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQ 177
E + RV+ ++ L L++LH+L I +RD+K ENVLL + ++ L+DFG S+ + + +
Sbjct: 133 FKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKE 192
Query: 178 PVLSETYCGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPF 225
S +CG++ Y APEI+R K K D WSLG++LF +L + PF
Sbjct: 193 RTFS--FCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPF 238
Score = 111 bits (266), Expect = 1e-23
Identities = 76/253 (30%), Positives = 127/253 (50%), Gaps = 23/253 (9%)
Query: 51 CKIIETAKAPKDFVVKFLPREIDV-------LVRL--NHPHLIHVHSIFQRKTKYYIFMR 101
C+ ++ ++F VK L R ++ +RL +HP+++++H + + Y+ +
Sbjct: 425 CRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLE 484
Query: 102 YTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH-ELEIAHRDIKCENVLL---TAN 157
G+LL +I K SE++A R L + ++H E + HRD+K EN+L T
Sbjct: 485 LLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPG 544
Query: 158 FNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFV 217
VK+ DFGF+R +S P+ +T C ++ YAAPE+L + Y + DLWSLGV+L++
Sbjct: 545 APVKIIDFGFARLRPQSPGVPM--QTPCFTLQYAAPELLAQQGY-DESCDLWSLGVILYM 601
Query: 218 MLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASI-------LSLECKTVVKHLLEPDPGL 270
ML+ +PF + Q + R S+ +S E K +V+ LL DP
Sbjct: 602 MLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAK 661
Query: 271 RHSATNVLDSEWI 283
R + S W+
Sbjct: 662 RLKLEGLRGSSWL 674
Score = 104 bits (249), Expect = 1e-21
Identities = 50/145 (34%), Positives = 89/145 (61%), Gaps = 2/145 (1%)
Query: 385 PHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHEL 444
P LV H FQ K + + Y+ G++ + QR +E + R++ ++ LA++++H+L
Sbjct: 96 PFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKL 155
Query: 445 EIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTP 504
I +RD+K ENVLL + ++ L+DFG ++ + ++ + R+ +FCG++ Y APEI++
Sbjct: 156 GIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEE--KERTFSFCGTIEYMAPEIIRSKT 213
Query: 505 YLPKPTDVWSLGIVVYVMLNRAMPF 529
K D WSLGI+++ +L A PF
Sbjct: 214 GHGKAVDWWSLGILLFELLTGASPF 238
Score = 101 bits (241), Expect = 1e-20
Identities = 67/226 (29%), Positives = 115/226 (50%), Gaps = 15/226 (6%)
Query: 374 REIEML-IKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTR 432
RE+ L + SHP++V+ H + + ++ + + G+LLE + ++ E +A R
Sbjct: 452 REVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILR 511
Query: 433 QLALAIQYMH-ELEIAHRDIKCENVLL---TANQNVKLSDFGFARMCVDKKLNEIRSETF 488
L A+ +MH E + HRD+K EN+L T VK+ DFGFAR+ + + +T
Sbjct: 512 SLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARL--RPQSPGVPMQTP 569
Query: 489 CGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIK--QLHQAQI---- 542
C +L Y APE+L Y + D+WSLG+++Y+ML+ +PF+ + Q A+I
Sbjct: 570 CFTLQYAAPELLAQQGY-DESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKI 628
Query: 543 -NKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+ +S+ K L+ +L + RLK+ + S W+
Sbjct: 629 REGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRGSSWL 674
>BC027464-1|AAH27464.1| 403|Homo sapiens aurora kinase A protein.
Length = 403
Score = 128 bits (308), Expect = 8e-29
Identities = 78/283 (27%), Positives = 138/283 (48%), Gaps = 14/283 (4%)
Query: 5 KTTPSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFV 64
K S++ + +++ + +G+G + VYL ++E K LA K++ A+ K V
Sbjct: 119 KNEESKKRQWALEDFEIGRPLGKGKFGNVYL----AREKQSKFILALKVLFKAQLEKAGV 174
Query: 65 VKFLPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQAR 124
L RE+++ L HP+++ ++ F T+ Y+ + Y G + + K E +
Sbjct: 175 EHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTA 234
Query: 125 VWTRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETY 184
+ +LA L Y H + HRDIK EN+LL + +K++DFG+S S T
Sbjct: 235 TYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRR-----TTL 289
Query: 185 CGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRF 244
CG++ Y PE++ G+ + K DLWSLGV+ + L PF+ ++ Y++ ++ F
Sbjct: 290 CGTLDYLPPEMIEGRMHDEK-VDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTF 348
Query: 245 RSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDS 287
V + ++ LL+ +P R VL+ WI +S
Sbjct: 349 PDFVTE----GARDLISRLLKHNPSQRPMLREVLEHPWITANS 387
Score = 109 bits (263), Expect = 2e-23
Identities = 68/251 (27%), Positives = 120/251 (47%), Gaps = 11/251 (4%)
Query: 341 YRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKY 400
Y K K ILA KV+ + + V+ L RE+E+ L HP+++ + F +
Sbjct: 148 YLAREKQSKF-ILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRV 206
Query: 401 FIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTA 460
++ + Y G + + + E + + +LA A+ Y H + HRDIK EN+LL +
Sbjct: 207 YLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS 266
Query: 461 NQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVY 520
+K++DFG++ R T CG+L Y PE+++G + K D+WSLG++ Y
Sbjct: 267 AGELKIADFGWSVHAPSS-----RRTTLCGTLDYLPPEMIEGRMHDEK-VDLWSLGVLCY 320
Query: 521 VMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYD 580
L PFE +Q + + + D +++ + LI +L+ N R + +
Sbjct: 321 EFLVGKPPFE----ANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLRE 376
Query: 581 IVNSEWIAMDS 591
++ WI +S
Sbjct: 377 VLEHPWITANS 387
>BC006423-1|AAH06423.1| 403|Homo sapiens aurora kinase A protein.
Length = 403
Score = 128 bits (308), Expect = 8e-29
Identities = 78/283 (27%), Positives = 138/283 (48%), Gaps = 14/283 (4%)
Query: 5 KTTPSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFV 64
K S++ + +++ + +G+G + VYL ++E K LA K++ A+ K V
Sbjct: 119 KNEESKKRQWALEDFEIGRPLGKGKFGNVYL----AREKQSKFILALKVLFKAQLEKAGV 174
Query: 65 VKFLPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQAR 124
L RE+++ L HP+++ ++ F T+ Y+ + Y G + + K E +
Sbjct: 175 EHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTA 234
Query: 125 VWTRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETY 184
+ +LA L Y H + HRDIK EN+LL + +K++DFG+S S T
Sbjct: 235 TYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRR-----TTL 289
Query: 185 CGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRF 244
CG++ Y PE++ G+ + K DLWSLGV+ + L PF+ ++ Y++ ++ F
Sbjct: 290 CGTLDYLPPEMIEGRMHDEK-VDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTF 348
Query: 245 RSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDS 287
V + ++ LL+ +P R VL+ WI +S
Sbjct: 349 PDFVTE----GARDLISRLLKHNPSQRPMLREVLEHPWITANS 387
Score = 109 bits (263), Expect = 2e-23
Identities = 68/251 (27%), Positives = 120/251 (47%), Gaps = 11/251 (4%)
Query: 341 YRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKY 400
Y K K ILA KV+ + + V+ L RE+E+ L HP+++ + F +
Sbjct: 148 YLAREKQSKF-ILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRV 206
Query: 401 FIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTA 460
++ + Y G + + + E + + +LA A+ Y H + HRDIK EN+LL +
Sbjct: 207 YLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS 266
Query: 461 NQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVY 520
+K++DFG++ R T CG+L Y PE+++G + K D+WSLG++ Y
Sbjct: 267 AGELKIADFGWSVHAPSS-----RRTTLCGTLDYLPPEMIEGRMHDEK-VDLWSLGVLCY 320
Query: 521 VMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYD 580
L PFE +Q + + + D +++ + LI +L+ N R + +
Sbjct: 321 EFLVGKPPFE----ANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLRE 376
Query: 581 IVNSEWIAMDS 591
++ WI +S
Sbjct: 377 VLEHPWITANS 387
>BC002499-1|AAH02499.1| 403|Homo sapiens AURKA protein protein.
Length = 403
Score = 128 bits (308), Expect = 8e-29
Identities = 78/283 (27%), Positives = 138/283 (48%), Gaps = 14/283 (4%)
Query: 5 KTTPSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFV 64
K S++ + +++ + +G+G + VYL ++E K LA K++ A+ K V
Sbjct: 119 KNEESKKRQWALEDFEIGRPLGKGKFGNVYL----AREKQSKFILALKVLFKAQLEKAGV 174
Query: 65 VKFLPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQAR 124
L RE+++ L HP+++ ++ F T+ Y+ + Y G + + K E +
Sbjct: 175 EHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTA 234
Query: 125 VWTRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETY 184
+ +LA L Y H + HRDIK EN+LL + +K++DFG+S S T
Sbjct: 235 TYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRR-----TTL 289
Query: 185 CGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRF 244
CG++ Y PE++ G+ + K DLWSLGV+ + L PF+ ++ Y++ ++ F
Sbjct: 290 CGTLDYLPPEMIEGRMHDEK-VDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTF 348
Query: 245 RSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDS 287
V + ++ LL+ +P R VL+ WI +S
Sbjct: 349 PDFVTE----GARDLISRLLKHNPSQRPMLREVLEHPWITANS 387
Score = 109 bits (263), Expect = 2e-23
Identities = 68/251 (27%), Positives = 120/251 (47%), Gaps = 11/251 (4%)
Query: 341 YRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKY 400
Y K K ILA KV+ + + V+ L RE+E+ L HP+++ + F +
Sbjct: 148 YLAREKQSKF-ILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRV 206
Query: 401 FIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTA 460
++ + Y G + + + E + + +LA A+ Y H + HRDIK EN+LL +
Sbjct: 207 YLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS 266
Query: 461 NQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVY 520
+K++DFG++ R T CG+L Y PE+++G + K D+WSLG++ Y
Sbjct: 267 AGELKIADFGWSVHAPSS-----RRTTLCGTLDYLPPEMIEGRMHDEK-VDLWSLGVLCY 320
Query: 521 VMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYD 580
L PFE +Q + + + D +++ + LI +L+ N R + +
Sbjct: 321 EFLVGKPPFE----ANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLRE 376
Query: 581 IVNSEWIAMDS 591
++ WI +S
Sbjct: 377 VLEHPWITANS 387
>BC001280-1|AAH01280.1| 403|Homo sapiens aurora kinase A protein.
Length = 403
Score = 128 bits (308), Expect = 8e-29
Identities = 78/283 (27%), Positives = 138/283 (48%), Gaps = 14/283 (4%)
Query: 5 KTTPSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFV 64
K S++ + +++ + +G+G + VYL ++E K LA K++ A+ K V
Sbjct: 119 KNEESKKRQWALEDFEIGRPLGKGKFGNVYL----AREKQSKFILALKVLFKAQLEKAGV 174
Query: 65 VKFLPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQAR 124
L RE+++ L HP+++ ++ F T+ Y+ + Y G + + K E +
Sbjct: 175 EHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTA 234
Query: 125 VWTRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETY 184
+ +LA L Y H + HRDIK EN+LL + +K++DFG+S S T
Sbjct: 235 TYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRR-----TTL 289
Query: 185 CGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRF 244
CG++ Y PE++ G+ + K DLWSLGV+ + L PF+ ++ Y++ ++ F
Sbjct: 290 CGTLDYLPPEMIEGRMHDEK-VDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTF 348
Query: 245 RSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDS 287
V + ++ LL+ +P R VL+ WI +S
Sbjct: 349 PDFVTE----GARDLISRLLKHNPSQRPMLREVLEHPWITANS 387
Score = 109 bits (263), Expect = 2e-23
Identities = 68/251 (27%), Positives = 120/251 (47%), Gaps = 11/251 (4%)
Query: 341 YRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKY 400
Y K K ILA KV+ + + V+ L RE+E+ L HP+++ + F +
Sbjct: 148 YLAREKQSKF-ILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRV 206
Query: 401 FIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTA 460
++ + Y G + + + E + + +LA A+ Y H + HRDIK EN+LL +
Sbjct: 207 YLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS 266
Query: 461 NQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVY 520
+K++DFG++ R T CG+L Y PE+++G + K D+WSLG++ Y
Sbjct: 267 AGELKIADFGWSVHAPSS-----RRTTLCGTLDYLPPEMIEGRMHDEK-VDLWSLGVLCY 320
Query: 521 VMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYD 580
L PFE +Q + + + D +++ + LI +L+ N R + +
Sbjct: 321 EFLVGKPPFE----ANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLRE 376
Query: 581 IVNSEWIAMDS 591
++ WI +S
Sbjct: 377 VLEHPWITANS 387
>AL121914-3|CAC12717.1| 403|Homo sapiens aurora kinase A protein.
Length = 403
Score = 128 bits (308), Expect = 8e-29
Identities = 78/283 (27%), Positives = 138/283 (48%), Gaps = 14/283 (4%)
Query: 5 KTTPSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFV 64
K S++ + +++ + +G+G + VYL ++E K LA K++ A+ K V
Sbjct: 119 KNEESKKRQWALEDFEIGRPLGKGKFGNVYL----AREKQSKFILALKVLFKAQLEKAGV 174
Query: 65 VKFLPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQAR 124
L RE+++ L HP+++ ++ F T+ Y+ + Y G + + K E +
Sbjct: 175 EHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTA 234
Query: 125 VWTRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETY 184
+ +LA L Y H + HRDIK EN+LL + +K++DFG+S S T
Sbjct: 235 TYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRR-----TTL 289
Query: 185 CGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRF 244
CG++ Y PE++ G+ + K DLWSLGV+ + L PF+ ++ Y++ ++ F
Sbjct: 290 CGTLDYLPPEMIEGRMHDEK-VDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTF 348
Query: 245 RSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDS 287
V + ++ LL+ +P R VL+ WI +S
Sbjct: 349 PDFVTE----GARDLISRLLKHNPSQRPMLREVLEHPWITANS 387
Score = 109 bits (263), Expect = 2e-23
Identities = 68/251 (27%), Positives = 120/251 (47%), Gaps = 11/251 (4%)
Query: 341 YRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKY 400
Y K K ILA KV+ + + V+ L RE+E+ L HP+++ + F +
Sbjct: 148 YLAREKQSKF-ILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRV 206
Query: 401 FIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTA 460
++ + Y G + + + E + + +LA A+ Y H + HRDIK EN+LL +
Sbjct: 207 YLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS 266
Query: 461 NQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVY 520
+K++DFG++ R T CG+L Y PE+++G + K D+WSLG++ Y
Sbjct: 267 AGELKIADFGWSVHAPSS-----RRTTLCGTLDYLPPEMIEGRMHDEK-VDLWSLGVLCY 320
Query: 521 VMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYD 580
L PFE +Q + + + D +++ + LI +L+ N R + +
Sbjct: 321 EFLVGKPPFE----ANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLRE 376
Query: 581 IVNSEWIAMDS 591
++ WI +S
Sbjct: 377 VLEHPWITANS 387
>AF195947-1|AAF29508.1| 403|Homo sapiens STK15 serine/threonine
kinase protein.
Length = 403
Score = 128 bits (308), Expect = 8e-29
Identities = 78/283 (27%), Positives = 138/283 (48%), Gaps = 14/283 (4%)
Query: 5 KTTPSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFV 64
K S++ + +++ + +G+G + VYL ++E K LA K++ A+ K V
Sbjct: 119 KNEESKKRQWALEDFEIGRPLGKGKFGNVYL----AREKQSKFILALKVLFKAQLEKAGV 174
Query: 65 VKFLPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQAR 124
L RE+++ L HP+++ ++ F T+ Y+ + Y G + + K E +
Sbjct: 175 EHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTA 234
Query: 125 VWTRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETY 184
+ +LA L Y H + HRDIK EN+LL + +K++DFG+S S T
Sbjct: 235 TYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRR-----TTL 289
Query: 185 CGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRF 244
CG++ Y PE++ G+ + K DLWSLGV+ + L PF+ ++ Y++ ++ F
Sbjct: 290 CGTLDYLPPEMIEGRMHDEK-VDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTF 348
Query: 245 RSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDS 287
V + ++ LL+ +P R VL+ WI +S
Sbjct: 349 PDFVTE----GARDLISRLLKHNPSQRPMLREVLEHPWITANS 387
Score = 109 bits (263), Expect = 2e-23
Identities = 68/251 (27%), Positives = 120/251 (47%), Gaps = 11/251 (4%)
Query: 341 YRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKY 400
Y K K ILA KV+ + + V+ L RE+E+ L HP+++ + F +
Sbjct: 148 YLAREKQSKF-ILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRV 206
Query: 401 FIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTA 460
++ + Y G + + + E + + +LA A+ Y H + HRDIK EN+LL +
Sbjct: 207 YLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS 266
Query: 461 NQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVY 520
+K++DFG++ R T CG+L Y PE+++G + K D+WSLG++ Y
Sbjct: 267 AGELKIADFGWSVHAPSS-----RRTTLCGTLDYLPPEMIEGRMHDEK-VDLWSLGVLCY 320
Query: 521 VMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYD 580
L PFE +Q + + + D +++ + LI +L+ N R + +
Sbjct: 321 EFLVGKPPFE----ANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLRE 376
Query: 581 IVNSEWIAMDS 591
++ WI +S
Sbjct: 377 VLEHPWITANS 387
>AF074715-1|AAC67395.1| 705|Homo sapiens mitogen- and
stress-activated protein kinase-2 protein.
Length = 705
Score = 128 bits (308), Expect = 8e-29
Identities = 74/227 (32%), Positives = 123/227 (54%), Gaps = 8/227 (3%)
Query: 2 TDLKTTPSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETA---K 58
T+ T EE + + ++L K +G GAY KV+L + D+ K A K++ A +
Sbjct: 1 TEANLTGHEEKVSV-ENFELLKVLGTGAYGKVFLVRKAGGHDAGK-LYAMKVLRKAALVQ 58
Query: 59 APKDFVVKFLPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCV 118
K R + LVR P L+ +H FQ K ++ + Y G++ +++ +
Sbjct: 59 RAKTQEHTRTERSVLELVR-QAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYF 117
Query: 119 SENQARVWTRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQP 178
E + RV+ ++ L L++LH+L I +RD+K ENVLL + ++ L+DFG S+ + + +
Sbjct: 118 KEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKER 177
Query: 179 VLSETYCGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPF 225
S +CG++ Y APEI+R K K D WSLG++LF +L + PF
Sbjct: 178 TFS--FCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPF 222
Score = 111 bits (266), Expect = 1e-23
Identities = 76/253 (30%), Positives = 127/253 (50%), Gaps = 23/253 (9%)
Query: 51 CKIIETAKAPKDFVVKFLPREIDV-------LVRL--NHPHLIHVHSIFQRKTKYYIFMR 101
C+ ++ ++F VK L R ++ +RL +HP+++++H + + Y+ +
Sbjct: 403 CRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLE 462
Query: 102 YTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLH-ELEIAHRDIKCENVLL---TAN 157
G+LL +I K SE++A R L + ++H E + HRD+K EN+L T
Sbjct: 463 LLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPG 522
Query: 158 FNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFV 217
VK+ DFGF+R +S P+ +T C ++ YAAPE+L + Y + DLWSLGV+L++
Sbjct: 523 APVKIIDFGFARLRPQSPGVPM--QTPCFTLQYAAPELLAQQGY-DESCDLWSLGVILYM 579
Query: 218 MLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASI-------LSLECKTVVKHLLEPDPGL 270
ML+ +PF + Q + R S+ +S E K +V+ LL DP
Sbjct: 580 MLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAK 639
Query: 271 RHSATNVLDSEWI 283
R + S W+
Sbjct: 640 RLKLEGLRGSSWL 652
Score = 104 bits (249), Expect = 1e-21
Identities = 50/145 (34%), Positives = 89/145 (61%), Gaps = 2/145 (1%)
Query: 385 PHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHEL 444
P LV H FQ K + + Y+ G++ + QR +E + R++ ++ LA++++H+L
Sbjct: 80 PFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKL 139
Query: 445 EIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTP 504
I +RD+K ENVLL + ++ L+DFG ++ + ++ + R+ +FCG++ Y APEI++
Sbjct: 140 GIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEE--KERTFSFCGTIEYMAPEIIRSKT 197
Query: 505 YLPKPTDVWSLGIVVYVMLNRAMPF 529
K D WSLGI+++ +L A PF
Sbjct: 198 GHGKAVDWWSLGILLFELLTGASPF 222
Score = 101 bits (241), Expect = 1e-20
Identities = 67/226 (29%), Positives = 115/226 (50%), Gaps = 15/226 (6%)
Query: 374 REIEML-IKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTR 432
RE+ L + SHP++V+ H + + ++ + + G+LLE + ++ E +A R
Sbjct: 430 REVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILR 489
Query: 433 QLALAIQYMH-ELEIAHRDIKCENVLL---TANQNVKLSDFGFARMCVDKKLNEIRSETF 488
L A+ +MH E + HRD+K EN+L T VK+ DFGFAR+ + + +T
Sbjct: 490 SLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARL--RPQSPGVPMQTP 547
Query: 489 CGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIK--QLHQAQI---- 542
C +L Y APE+L Y + D+WSLG+++Y+ML+ +PF+ + Q A+I
Sbjct: 548 CFTLQYAAPELLAQQGY-DESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKI 606
Query: 543 -NKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWI 587
+ +S+ K L+ +L + RLK+ + S W+
Sbjct: 607 REGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRGSSWL 652
>AF011468-1|AAC63902.1| 403|Homo sapiens serine/threonine kinase
protein.
Length = 403
Score = 128 bits (308), Expect = 8e-29
Identities = 78/283 (27%), Positives = 138/283 (48%), Gaps = 14/283 (4%)
Query: 5 KTTPSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFV 64
K S++ + +++ + +G+G + VYL ++E K LA K++ A+ K V
Sbjct: 119 KNEESKKRQWALEDFEIGRPLGKGKFGNVYL----AREKQSKFILALKVLFKAQLEKAGV 174
Query: 65 VKFLPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQAR 124
L RE+++ L HP+++ ++ F T+ Y+ + Y G + + K E +
Sbjct: 175 EHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTA 234
Query: 125 VWTRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETY 184
+ +LA L Y H + HRDIK EN+LL + +K++DFG+S S T
Sbjct: 235 TYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRR-----TTL 289
Query: 185 CGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRF 244
CG++ Y PE++ G+ + K DLWSLGV+ + L PF+ ++ Y++ ++ F
Sbjct: 290 CGTLDYLPPEMIEGRMHDEK-VDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTF 348
Query: 245 RSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDS 287
V + ++ LL+ +P R VL+ WI +S
Sbjct: 349 PDFVTE----GARDLISRLLKHNPSQRPMLREVLEHPWITANS 387
Score = 109 bits (263), Expect = 2e-23
Identities = 68/251 (27%), Positives = 120/251 (47%), Gaps = 11/251 (4%)
Query: 341 YRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKY 400
Y K K ILA KV+ + + V+ L RE+E+ L HP+++ + F +
Sbjct: 148 YLAREKQSKF-ILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRV 206
Query: 401 FIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTA 460
++ + Y G + + + E + + +LA A+ Y H + HRDIK EN+LL +
Sbjct: 207 YLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS 266
Query: 461 NQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVY 520
+K++DFG++ R T CG+L Y PE+++G + K D+WSLG++ Y
Sbjct: 267 AGELKIADFGWSVHAPSS-----RRTTLCGTLDYLPPEMIEGRMHDEK-VDLWSLGVLCY 320
Query: 521 VMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYD 580
L PFE +Q + + + D +++ + LI +L+ N R + +
Sbjct: 321 EFLVGKPPFE----ANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLRE 376
Query: 581 IVNSEWIAMDS 591
++ WI +S
Sbjct: 377 VLEHPWITANS 387
>AF008551-1|AAC12708.1| 403|Homo sapiens aurora-related kinase 1
protein.
Length = 403
Score = 128 bits (308), Expect = 8e-29
Identities = 78/283 (27%), Positives = 138/283 (48%), Gaps = 14/283 (4%)
Query: 5 KTTPSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFV 64
K S++ + +++ + +G+G + VYL ++E K LA K++ A+ K V
Sbjct: 119 KNEESKKRQWALEDFEIGRPLGKGKFGNVYL----AREKQSKFILALKVLFKAQLEKAGV 174
Query: 65 VKFLPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQAR 124
L RE+++ L HP+++ ++ F T+ Y+ + Y G + + K E +
Sbjct: 175 EHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTA 234
Query: 125 VWTRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETY 184
+ +LA L Y H + HRDIK EN+LL + +K++DFG+S S T
Sbjct: 235 TYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRR-----TTL 289
Query: 185 CGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRF 244
CG++ Y PE++ G+ + K DLWSLGV+ + L PF+ ++ Y++ ++ F
Sbjct: 290 CGTLDYLPPEMIEGRMHDEK-VDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTF 348
Query: 245 RSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDS 287
V + ++ LL+ +P R VL+ WI +S
Sbjct: 349 PDFVTE----GARDLISRLLKHNPSQRPMLREVLEHPWITANS 387
Score = 109 bits (263), Expect = 2e-23
Identities = 68/251 (27%), Positives = 120/251 (47%), Gaps = 11/251 (4%)
Query: 341 YRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKY 400
Y K K ILA KV+ + + V+ L RE+E+ L HP+++ + F +
Sbjct: 148 YLAREKQSKF-ILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRV 206
Query: 401 FIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTA 460
++ + Y G + + + E + + +LA A+ Y H + HRDIK EN+LL +
Sbjct: 207 YLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS 266
Query: 461 NQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVY 520
+K++DFG++ R T CG+L Y PE+++G + K D+WSLG++ Y
Sbjct: 267 AGELKIADFGWSVHAPSS-----RRTTLCGTLDYLPPEMIEGRMHDEK-VDLWSLGVLCY 320
Query: 521 VMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYD 580
L PFE +Q + + + D +++ + LI +L+ N R + +
Sbjct: 321 EFLVGKPPFE----ANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLRE 376
Query: 581 IVNSEWIAMDS 591
++ WI +S
Sbjct: 377 VLEHPWITANS 387
>Z15108-1|CAA78813.1| 584|Homo sapiens protein kinase C zeta
protein.
Length = 584
Score = 127 bits (307), Expect = 1e-28
Identities = 76/254 (29%), Positives = 130/254 (51%), Gaps = 12/254 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
+ L + +G G+YAKV L + + A K+++ D + ++ E V +
Sbjct: 244 FDLIRVIGRGSYAKVLLVRLKKNDQIY----AMKVVKKELVHDDEDIDWVQTEKHVFEQA 299
Query: 79 N-HPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYL 137
+ +P L+ +HS FQ ++ ++ + Y GDL+ ++ + + E AR + ++ + L +L
Sbjct: 300 SSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFL 359
Query: 138 HELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILR 197
HE I +RD+K +NVLL A+ ++KL+D+G C E + T+CG+ +Y APEILR
Sbjct: 360 HERGIIYRDLKLDNVLLDADGHIKLTDYG---MCKEGLGPGDTTSTFCGTPNYIAPEILR 416
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFD---DTRMRKLYEQQMGKKYRFRSRVASILSL 254
G+ Y D W+LGV++F M+ PFD D + R+ LS+
Sbjct: 417 GEEY-GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 475
Query: 255 ECKTVVKHLLEPDP 268
+ V+K L DP
Sbjct: 476 KASHVLKGFLNKDP 489
Score = 108 bits (259), Expect = 7e-23
Identities = 62/186 (33%), Positives = 106/186 (56%), Gaps = 7/186 (3%)
Query: 346 KNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLS-HPHLVHTHSIFQRRYKYFIFM 404
KND+ I A KV+ D ++ E + + S +P LV HS FQ + F+ +
Sbjct: 265 KNDQ--IYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVI 322
Query: 405 RYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNV 464
Y+ GDL+ + ++ + E+ AR + ++ +A+ ++HE I +RD+K +NVLL A+ ++
Sbjct: 323 EYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHI 382
Query: 465 KLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLN 524
KL+D+G MC + + TFCG+ +Y APEIL+G Y D W+LG++++ M+
Sbjct: 383 KLTDYG---MCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY-GFSVDWWALGVLMFEMMA 438
Query: 525 RAMPFE 530
PF+
Sbjct: 439 GRSPFD 444
>BT007082-1|AAP35745.1| 592|Homo sapiens protein kinase C, zeta
protein.
Length = 592
Score = 127 bits (307), Expect = 1e-28
Identities = 76/254 (29%), Positives = 130/254 (51%), Gaps = 12/254 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
+ L + +G G+YAKV L + + A K+++ D + ++ E V +
Sbjct: 252 FDLIRVIGRGSYAKVLLVRLKKNDQIY----AMKVVKKELVHDDEDIDWVQTEKHVFEQA 307
Query: 79 N-HPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYL 137
+ +P L+ +HS FQ ++ ++ + Y GDL+ ++ + + E AR + ++ + L +L
Sbjct: 308 SSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFL 367
Query: 138 HELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILR 197
HE I +RD+K +NVLL A+ ++KL+D+G C E + T+CG+ +Y APEILR
Sbjct: 368 HERGIIYRDLKLDNVLLDADGHIKLTDYG---MCKEGLGPGDTTSTFCGTPNYIAPEILR 424
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFD---DTRMRKLYEQQMGKKYRFRSRVASILSL 254
G+ Y D W+LGV++F M+ PFD D + R+ LS+
Sbjct: 425 GEEY-GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 483
Query: 255 ECKTVVKHLLEPDP 268
+ V+K L DP
Sbjct: 484 KASHVLKGFLNKDP 497
Score = 108 bits (259), Expect = 7e-23
Identities = 62/186 (33%), Positives = 106/186 (56%), Gaps = 7/186 (3%)
Query: 346 KNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLS-HPHLVHTHSIFQRRYKYFIFM 404
KND+ I A KV+ D ++ E + + S +P LV HS FQ + F+ +
Sbjct: 273 KNDQ--IYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVI 330
Query: 405 RYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNV 464
Y+ GDL+ + ++ + E+ AR + ++ +A+ ++HE I +RD+K +NVLL A+ ++
Sbjct: 331 EYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHI 390
Query: 465 KLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLN 524
KL+D+G MC + + TFCG+ +Y APEIL+G Y D W+LG++++ M+
Sbjct: 391 KLTDYG---MCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY-GFSVDWWALGVLMFEMMA 446
Query: 525 RAMPFE 530
PF+
Sbjct: 447 GRSPFD 452
>BC014270-1|AAH14270.1| 592|Homo sapiens protein kinase C, zeta
protein.
Length = 592
Score = 127 bits (307), Expect = 1e-28
Identities = 76/254 (29%), Positives = 130/254 (51%), Gaps = 12/254 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
+ L + +G G+YAKV L + + A K+++ D + ++ E V +
Sbjct: 252 FDLIRVIGRGSYAKVLLVRLKKNDQIY----AMKVVKKELVHDDEDIDWVQTEKHVFEQA 307
Query: 79 N-HPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYL 137
+ +P L+ +HS FQ ++ ++ + Y GDL+ ++ + + E AR + ++ + L +L
Sbjct: 308 SSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFL 367
Query: 138 HELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILR 197
HE I +RD+K +NVLL A+ ++KL+D+G C E + T+CG+ +Y APEILR
Sbjct: 368 HERGIIYRDLKLDNVLLDADGHIKLTDYG---MCKEGLGPGDTTSTFCGTPNYIAPEILR 424
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFD---DTRMRKLYEQQMGKKYRFRSRVASILSL 254
G+ Y D W+LGV++F M+ PFD D + R+ LS+
Sbjct: 425 GEEY-GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 483
Query: 255 ECKTVVKHLLEPDP 268
+ V+K L DP
Sbjct: 484 KASHVLKGFLNKDP 497
Score = 108 bits (259), Expect = 7e-23
Identities = 62/186 (33%), Positives = 106/186 (56%), Gaps = 7/186 (3%)
Query: 346 KNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLS-HPHLVHTHSIFQRRYKYFIFM 404
KND+ I A KV+ D ++ E + + S +P LV HS FQ + F+ +
Sbjct: 273 KNDQ--IYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVI 330
Query: 405 RYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNV 464
Y+ GDL+ + ++ + E+ AR + ++ +A+ ++HE I +RD+K +NVLL A+ ++
Sbjct: 331 EYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHI 390
Query: 465 KLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLN 524
KL+D+G MC + + TFCG+ +Y APEIL+G Y D W+LG++++ M+
Sbjct: 391 KLTDYG---MCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY-GFSVDWWALGVLMFEMMA 446
Query: 525 RAMPFE 530
PF+
Sbjct: 447 GRSPFD 452
>BC008058-1|AAH08058.1| 592|Homo sapiens protein kinase C, zeta
protein.
Length = 592
Score = 127 bits (307), Expect = 1e-28
Identities = 76/254 (29%), Positives = 130/254 (51%), Gaps = 12/254 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
+ L + +G G+YAKV L + + A K+++ D + ++ E V +
Sbjct: 252 FDLIRVIGRGSYAKVLLVRLKKNDQIY----AMKVVKKELVHDDEDIDWVQTEKHVFEQA 307
Query: 79 N-HPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYL 137
+ +P L+ +HS FQ ++ ++ + Y GDL+ ++ + + E AR + ++ + L +L
Sbjct: 308 SSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFL 367
Query: 138 HELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILR 197
HE I +RD+K +NVLL A+ ++KL+D+G C E + T+CG+ +Y APEILR
Sbjct: 368 HERGIIYRDLKLDNVLLDADGHIKLTDYG---MCKEGLGPGDTTSTFCGTPNYIAPEILR 424
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFD---DTRMRKLYEQQMGKKYRFRSRVASILSL 254
G+ Y D W+LGV++F M+ PFD D + R+ LS+
Sbjct: 425 GEEY-GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 483
Query: 255 ECKTVVKHLLEPDP 268
+ V+K L DP
Sbjct: 484 KASHVLKGFLNKDP 497
Score = 108 bits (259), Expect = 7e-23
Identities = 62/186 (33%), Positives = 106/186 (56%), Gaps = 7/186 (3%)
Query: 346 KNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLS-HPHLVHTHSIFQRRYKYFIFM 404
KND+ I A KV+ D ++ E + + S +P LV HS FQ + F+ +
Sbjct: 273 KNDQ--IYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVI 330
Query: 405 RYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNV 464
Y+ GDL+ + ++ + E+ AR + ++ +A+ ++HE I +RD+K +NVLL A+ ++
Sbjct: 331 EYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHI 390
Query: 465 KLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLN 524
KL+D+G MC + + TFCG+ +Y APEIL+G Y D W+LG++++ M+
Sbjct: 391 KLTDYG---MCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY-GFSVDWWALGVLMFEMMA 446
Query: 525 RAMPFE 530
PF+
Sbjct: 447 GRSPFD 452
>AL645703-1|CAI21535.1| 592|Homo sapiens protein kinase C, zeta
protein.
Length = 592
Score = 127 bits (307), Expect = 1e-28
Identities = 76/254 (29%), Positives = 130/254 (51%), Gaps = 12/254 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
+ L + +G G+YAKV L + + A K+++ D + ++ E V +
Sbjct: 252 FDLIRVIGRGSYAKVLLVRLKKNDQIY----AMKVVKKELVHDDEDIDWVQTEKHVFEQA 307
Query: 79 N-HPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYL 137
+ +P L+ +HS FQ ++ ++ + Y GDL+ ++ + + E AR + ++ + L +L
Sbjct: 308 SSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFL 367
Query: 138 HELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILR 197
HE I +RD+K +NVLL A+ ++KL+D+G C E + T+CG+ +Y APEILR
Sbjct: 368 HERGIIYRDLKLDNVLLDADGHIKLTDYG---MCKEGLGPGDTTSTFCGTPNYIAPEILR 424
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFD---DTRMRKLYEQQMGKKYRFRSRVASILSL 254
G+ Y D W+LGV++F M+ PFD D + R+ LS+
Sbjct: 425 GEEY-GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 483
Query: 255 ECKTVVKHLLEPDP 268
+ V+K L DP
Sbjct: 484 KASHVLKGFLNKDP 497
Score = 108 bits (259), Expect = 7e-23
Identities = 62/186 (33%), Positives = 106/186 (56%), Gaps = 7/186 (3%)
Query: 346 KNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLS-HPHLVHTHSIFQRRYKYFIFM 404
KND+ I A KV+ D ++ E + + S +P LV HS FQ + F+ +
Sbjct: 273 KNDQ--IYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVI 330
Query: 405 RYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNV 464
Y+ GDL+ + ++ + E+ AR + ++ +A+ ++HE I +RD+K +NVLL A+ ++
Sbjct: 331 EYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHI 390
Query: 465 KLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLN 524
KL+D+G MC + + TFCG+ +Y APEIL+G Y D W+LG++++ M+
Sbjct: 391 KLTDYG---MCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY-GFSVDWWALGVLMFEMMA 446
Query: 525 RAMPFE 530
PF+
Sbjct: 447 GRSPFD 452
>AL590822-6|CAI12484.1| 592|Homo sapiens protein kinase C, zeta
protein.
Length = 592
Score = 127 bits (307), Expect = 1e-28
Identities = 76/254 (29%), Positives = 130/254 (51%), Gaps = 12/254 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
+ L + +G G+YAKV L + + A K+++ D + ++ E V +
Sbjct: 252 FDLIRVIGRGSYAKVLLVRLKKNDQIY----AMKVVKKELVHDDEDIDWVQTEKHVFEQA 307
Query: 79 N-HPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYL 137
+ +P L+ +HS FQ ++ ++ + Y GDL+ ++ + + E AR + ++ + L +L
Sbjct: 308 SSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFL 367
Query: 138 HELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILR 197
HE I +RD+K +NVLL A+ ++KL+D+G C E + T+CG+ +Y APEILR
Sbjct: 368 HERGIIYRDLKLDNVLLDADGHIKLTDYG---MCKEGLGPGDTTSTFCGTPNYIAPEILR 424
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFD---DTRMRKLYEQQMGKKYRFRSRVASILSL 254
G+ Y D W+LGV++F M+ PFD D + R+ LS+
Sbjct: 425 GEEY-GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 483
Query: 255 ECKTVVKHLLEPDP 268
+ V+K L DP
Sbjct: 484 KASHVLKGFLNKDP 497
Score = 108 bits (259), Expect = 7e-23
Identities = 62/186 (33%), Positives = 106/186 (56%), Gaps = 7/186 (3%)
Query: 346 KNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLS-HPHLVHTHSIFQRRYKYFIFM 404
KND+ I A KV+ D ++ E + + S +P LV HS FQ + F+ +
Sbjct: 273 KNDQ--IYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVI 330
Query: 405 RYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNV 464
Y+ GDL+ + ++ + E+ AR + ++ +A+ ++HE I +RD+K +NVLL A+ ++
Sbjct: 331 EYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHI 390
Query: 465 KLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLN 524
KL+D+G MC + + TFCG+ +Y APEIL+G Y D W+LG++++ M+
Sbjct: 391 KLTDYG---MCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY-GFSVDWWALGVLMFEMMA 446
Query: 525 RAMPFE 530
PF+
Sbjct: 447 GRSPFD 452
>AL391845-5|CAI15438.1| 592|Homo sapiens protein kinase C, zeta
protein.
Length = 592
Score = 127 bits (307), Expect = 1e-28
Identities = 76/254 (29%), Positives = 130/254 (51%), Gaps = 12/254 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
+ L + +G G+YAKV L + + A K+++ D + ++ E V +
Sbjct: 252 FDLIRVIGRGSYAKVLLVRLKKNDQIY----AMKVVKKELVHDDEDIDWVQTEKHVFEQA 307
Query: 79 N-HPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYL 137
+ +P L+ +HS FQ ++ ++ + Y GDL+ ++ + + E AR + ++ + L +L
Sbjct: 308 SSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFL 367
Query: 138 HELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILR 197
HE I +RD+K +NVLL A+ ++KL+D+G C E + T+CG+ +Y APEILR
Sbjct: 368 HERGIIYRDLKLDNVLLDADGHIKLTDYG---MCKEGLGPGDTTSTFCGTPNYIAPEILR 424
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFD---DTRMRKLYEQQMGKKYRFRSRVASILSL 254
G+ Y D W+LGV++F M+ PFD D + R+ LS+
Sbjct: 425 GEEY-GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 483
Query: 255 ECKTVVKHLLEPDP 268
+ V+K L DP
Sbjct: 484 KASHVLKGFLNKDP 497
Score = 108 bits (259), Expect = 7e-23
Identities = 62/186 (33%), Positives = 106/186 (56%), Gaps = 7/186 (3%)
Query: 346 KNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLS-HPHLVHTHSIFQRRYKYFIFM 404
KND+ I A KV+ D ++ E + + S +P LV HS FQ + F+ +
Sbjct: 273 KNDQ--IYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVI 330
Query: 405 RYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNV 464
Y+ GDL+ + ++ + E+ AR + ++ +A+ ++HE I +RD+K +NVLL A+ ++
Sbjct: 331 EYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHI 390
Query: 465 KLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLN 524
KL+D+G MC + + TFCG+ +Y APEIL+G Y D W+LG++++ M+
Sbjct: 391 KLTDYG---MCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY-GFSVDWWALGVLMFEMMA 446
Query: 525 RAMPFE 530
PF+
Sbjct: 447 GRSPFD 452
>L14283-1|AAA36488.1| 592|Homo sapiens protein kinase C zeta
protein.
Length = 592
Score = 127 bits (306), Expect = 1e-28
Identities = 76/254 (29%), Positives = 129/254 (50%), Gaps = 12/254 (4%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
+ L + +G G YAKV L + + A K+++ D + ++ E V +
Sbjct: 252 FDLIRVIGRGTYAKVLLVRLKKNDQIY----AMKVVKKELVHDDEDIDWVQTEKHVFEQA 307
Query: 79 N-HPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYL 137
+ +P L+ +HS FQ ++ ++ + Y GDL+ ++ + + E AR + ++ + L +L
Sbjct: 308 SSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFL 367
Query: 138 HELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILR 197
HE I +RD+K +NVLL A+ ++KL+D+G C E + T+CG+ +Y APEILR
Sbjct: 368 HERGIIYRDLKLDNVLLDADGHIKLTDYG---MCKEGLGPGDTTSTFCGTPNYIAPEILR 424
Query: 198 GKPYCPKPTDLWSLGVVLFVMLNKSMPFD---DTRMRKLYEQQMGKKYRFRSRVASILSL 254
G+ Y D W+LGV++F M+ PFD D + R+ LS+
Sbjct: 425 GEEY-GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 483
Query: 255 ECKTVVKHLLEPDP 268
+ V+K L DP
Sbjct: 484 KASHVLKGFLNKDP 497
Score = 108 bits (259), Expect = 7e-23
Identities = 62/186 (33%), Positives = 106/186 (56%), Gaps = 7/186 (3%)
Query: 346 KNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLS-HPHLVHTHSIFQRRYKYFIFM 404
KND+ I A KV+ D ++ E + + S +P LV HS FQ + F+ +
Sbjct: 273 KNDQ--IYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVI 330
Query: 405 RYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNV 464
Y+ GDL+ + ++ + E+ AR + ++ +A+ ++HE I +RD+K +NVLL A+ ++
Sbjct: 331 EYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHI 390
Query: 465 KLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLN 524
KL+D+G MC + + TFCG+ +Y APEIL+G Y D W+LG++++ M+
Sbjct: 391 KLTDYG---MCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY-GFSVDWWALGVLMFEMMA 446
Query: 525 RAMPFE 530
PF+
Sbjct: 447 GRSPFD 452
>BC128511-1|AAI28512.1| 1102|Homo sapiens KIAA0999 protein protein.
Length = 1102
Score = 127 bits (306), Expect = 1e-28
Identities = 65/191 (34%), Positives = 109/191 (57%), Gaps = 9/191 (4%)
Query: 118 VSENQARVWTRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQ 177
++E +AR +Q+ + + H I HRD+K EN+LL AN N+K++DFGFS
Sbjct: 1 MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQ-- 58
Query: 178 PVLSETYCGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQ 237
L +T+CGS YAAPE+ GK Y D+WSLGVVL+V++ ++PFD + ++ L +
Sbjct: 59 --LLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARV 116
Query: 238 MGKKYRFRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRLTTLNAVEA 297
+ K+ R+ +S EC+ +++H+L DP R S + +W+ + + +
Sbjct: 117 LSGKF----RIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRL-I 171
Query: 298 AALKRAKEDRR 308
A ++ KE+R+
Sbjct: 172 AECQQLKEERQ 182
Score = 110 bits (265), Expect = 1e-23
Identities = 60/166 (36%), Positives = 98/166 (59%), Gaps = 8/166 (4%)
Query: 424 EDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEI 483
E +AR +Q+ A+ + H I HRD+K EN+LL AN N+K++DFGF+ + +L
Sbjct: 3 EKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQL--- 59
Query: 484 RSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQIN 543
+T+CGS Y APE+ +G Y D+WSLG+V+YV++ A+PF+ ++ L +A++
Sbjct: 60 -LKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNL-RARV- 116
Query: 544 KNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAM 589
+ KFR + +S C+ LI ML + RL + I +W+ +
Sbjct: 117 LSGKFRIPFF--MSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKL 160
>AF145711-1|AAD30559.1| 489|Homo sapiens
calcium/calmodulin-dependent protein kinase II alpha-B
subunit protein.
Length = 489
Score = 125 bits (302), Expect = 4e-28
Identities = 89/302 (29%), Positives = 144/302 (47%), Gaps = 13/302 (4%)
Query: 13 TLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREI 72
T T+ Y+L + +G+GA++ V + A KII T K K L RE
Sbjct: 7 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEY----AAKIINTKKLSARDHQK-LEREA 61
Query: 73 DVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLAL 132
+ L HP+++ +H + +Y+ G+L I+ SE A +Q+
Sbjct: 62 RICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILE 121
Query: 133 GLQYLHELEIAHRDIKCENVLLTANFN---VKLSDFGFSRFCVESDNQPVLSETYCGSMS 189
+ + H++ + HRD+K EN+LL + VKL+DFG + VE + Q + G+
Sbjct: 122 AVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLA-IEVEGEQQAWFG--FAGTPG 178
Query: 190 YAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVA 249
Y +PE+LR PY KP DLW+ GV+L+++L PF D +LY+Q Y F S
Sbjct: 179 YLSPEVLRKDPY-GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEW 237
Query: 250 SILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRLTT-LNAVEAAALKRAKEDRR 308
++ E K ++ +L +P R +A L WI+ S + + ++ E + RR
Sbjct: 238 DTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARR 297
Query: 309 KL 310
KL
Sbjct: 298 KL 299
Score = 117 bits (282), Expect = 1e-25
Identities = 86/276 (31%), Positives = 138/276 (50%), Gaps = 13/276 (4%)
Query: 354 ACKVIDTST-APRDFVKKFLPREIEMLIKLSHPHLVHTH-SIFQRRYKYFIFMRYMERGD 411
A K+I+T + RD K L RE + L HP++V H SI + + Y IF + G+
Sbjct: 40 AAKIINTKKLSARDHQK--LEREARICRLLKHPNIVRLHDSISEEGHHYLIF-DLVTGGE 96
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQN---VKLSD 468
L E ++ R E A +Q+ A+ + H++ + HRD+K EN+LL + VKL+D
Sbjct: 97 LFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLAD 156
Query: 469 FGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMP 528
FG A ++ + + F G+ Y +PE+L+ PY KP D+W+ G+++Y++L P
Sbjct: 157 FGLA---IEVEGEQQAWFGFAGTPGYLSPEVLRKDPY-GKPVDLWACGVILYILLVGYPP 212
Query: 529 FEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIA 588
F D+ +L+Q + F S DT++ K LI ML N R+ + + WI+
Sbjct: 213 FWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 272
Query: 589 MDSRLLE-WTPQETLAYKKAREEKNKLHKTVETVEL 623
S + QET+ K + KL + T L
Sbjct: 273 HRSTVASCMHRQETVDCLKKFNARRKLKGAILTTML 308
>AF145710-1|AAD30558.1| 478|Homo sapiens
calcium/calmodulin-dependent protein kinase II alpha
subunit protein.
Length = 478
Score = 125 bits (302), Expect = 4e-28
Identities = 89/302 (29%), Positives = 144/302 (47%), Gaps = 13/302 (4%)
Query: 13 TLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREI 72
T T+ Y+L + +G+GA++ V + A KII T K K L RE
Sbjct: 7 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEY----AAKIINTKKLSARDHQK-LEREA 61
Query: 73 DVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLAL 132
+ L HP+++ +H + +Y+ G+L I+ SE A +Q+
Sbjct: 62 RICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILE 121
Query: 133 GLQYLHELEIAHRDIKCENVLLTANFN---VKLSDFGFSRFCVESDNQPVLSETYCGSMS 189
+ + H++ + HRD+K EN+LL + VKL+DFG + VE + Q + G+
Sbjct: 122 AVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLA-IEVEGEQQAWFG--FAGTPG 178
Query: 190 YAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVA 249
Y +PE+LR PY KP DLW+ GV+L+++L PF D +LY+Q Y F S
Sbjct: 179 YLSPEVLRKDPY-GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEW 237
Query: 250 SILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRLTT-LNAVEAAALKRAKEDRR 308
++ E K ++ +L +P R +A L WI+ S + + ++ E + RR
Sbjct: 238 DTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARR 297
Query: 309 KL 310
KL
Sbjct: 298 KL 299
Score = 117 bits (282), Expect = 1e-25
Identities = 86/276 (31%), Positives = 138/276 (50%), Gaps = 13/276 (4%)
Query: 354 ACKVIDTST-APRDFVKKFLPREIEMLIKLSHPHLVHTH-SIFQRRYKYFIFMRYMERGD 411
A K+I+T + RD K L RE + L HP++V H SI + + Y IF + G+
Sbjct: 40 AAKIINTKKLSARDHQK--LEREARICRLLKHPNIVRLHDSISEEGHHYLIF-DLVTGGE 96
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQN---VKLSD 468
L E ++ R E A +Q+ A+ + H++ + HRD+K EN+LL + VKL+D
Sbjct: 97 LFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLAD 156
Query: 469 FGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMP 528
FG A ++ + + F G+ Y +PE+L+ PY KP D+W+ G+++Y++L P
Sbjct: 157 FGLA---IEVEGEQQAWFGFAGTPGYLSPEVLRKDPY-GKPVDLWACGVILYILLVGYPP 212
Query: 529 FEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIA 588
F D+ +L+Q + F S DT++ K LI ML N R+ + + WI+
Sbjct: 213 FWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 272
Query: 589 MDSRLLE-WTPQETLAYKKAREEKNKLHKTVETVEL 623
S + QET+ K + KL + T L
Sbjct: 273 HRSTVASCMHRQETVDCLKKFNARRKLKGAILTTML 308
>AF091486-1|AAD55815.1| 478|Homo sapiens calmodulin-dependent
protein kinase II alpha protein.
Length = 478
Score = 125 bits (302), Expect = 4e-28
Identities = 89/302 (29%), Positives = 144/302 (47%), Gaps = 13/302 (4%)
Query: 13 TLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREI 72
T T+ Y+L + +G+GA++ V + A KII T K K L RE
Sbjct: 7 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEY----AAKIINTKKLSARDHQK-LEREA 61
Query: 73 DVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLAL 132
+ L HP+++ +H + +Y+ G+L I+ SE A +Q+
Sbjct: 62 RICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILE 121
Query: 133 GLQYLHELEIAHRDIKCENVLLTANFN---VKLSDFGFSRFCVESDNQPVLSETYCGSMS 189
+ + H++ + HRD+K EN+LL + VKL+DFG + VE + Q + G+
Sbjct: 122 AVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLA-IEVEGEQQAWFG--FAGTPG 178
Query: 190 YAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVA 249
Y +PE+LR PY KP DLW+ GV+L+++L PF D +LY+Q Y F S
Sbjct: 179 YLSPEVLRKDPY-GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEW 237
Query: 250 SILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRLTT-LNAVEAAALKRAKEDRR 308
++ E K ++ +L +P R +A L WI+ S + + ++ E + RR
Sbjct: 238 DTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARR 297
Query: 309 KL 310
KL
Sbjct: 298 KL 299
Score = 117 bits (282), Expect = 1e-25
Identities = 86/276 (31%), Positives = 138/276 (50%), Gaps = 13/276 (4%)
Query: 354 ACKVIDTST-APRDFVKKFLPREIEMLIKLSHPHLVHTH-SIFQRRYKYFIFMRYMERGD 411
A K+I+T + RD K L RE + L HP++V H SI + + Y IF + G+
Sbjct: 40 AAKIINTKKLSARDHQK--LEREARICRLLKHPNIVRLHDSISEEGHHYLIF-DLVTGGE 96
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQN---VKLSD 468
L E ++ R E A +Q+ A+ + H++ + HRD+K EN+LL + VKL+D
Sbjct: 97 LFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLAD 156
Query: 469 FGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMP 528
FG A ++ + + F G+ Y +PE+L+ PY KP D+W+ G+++Y++L P
Sbjct: 157 FGLA---IEVEGEQQAWFGFAGTPGYLSPEVLRKDPY-GKPVDLWACGVILYILLVGYPP 212
Query: 529 FEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIA 588
F D+ +L+Q + F S DT++ K LI ML N R+ + + WI+
Sbjct: 213 FWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 272
Query: 589 MDSRLLE-WTPQETLAYKKAREEKNKLHKTVETVEL 623
S + QET+ K + KL + T L
Sbjct: 273 HRSTVASCMHRQETVDCLKKFNARRKLKGAILTTML 308
>AB023185-1|BAA76812.1| 527|Homo sapiens KIAA0968 protein protein.
Length = 527
Score = 125 bits (302), Expect = 4e-28
Identities = 89/302 (29%), Positives = 144/302 (47%), Gaps = 13/302 (4%)
Query: 13 TLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREI 72
T T+ Y+L + +G+GA++ V + A KII T K K L RE
Sbjct: 56 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEY----AAKIINTKKLSARDHQK-LEREA 110
Query: 73 DVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLAL 132
+ L HP+++ +H + +Y+ G+L I+ SE A +Q+
Sbjct: 111 RICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILE 170
Query: 133 GLQYLHELEIAHRDIKCENVLLTANFN---VKLSDFGFSRFCVESDNQPVLSETYCGSMS 189
+ + H++ + HRD+K EN+LL + VKL+DFG + VE + Q + G+
Sbjct: 171 AVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLA-IEVEGEQQAWFG--FAGTPG 227
Query: 190 YAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVA 249
Y +PE+LR PY KP DLW+ GV+L+++L PF D +LY+Q Y F S
Sbjct: 228 YLSPEVLRKDPY-GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEW 286
Query: 250 SILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRLTT-LNAVEAAALKRAKEDRR 308
++ E K ++ +L +P R +A L WI+ S + + ++ E + RR
Sbjct: 287 DTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARR 346
Query: 309 KL 310
KL
Sbjct: 347 KL 348
Score = 117 bits (282), Expect = 1e-25
Identities = 86/276 (31%), Positives = 138/276 (50%), Gaps = 13/276 (4%)
Query: 354 ACKVIDTST-APRDFVKKFLPREIEMLIKLSHPHLVHTH-SIFQRRYKYFIFMRYMERGD 411
A K+I+T + RD K L RE + L HP++V H SI + + Y IF + G+
Sbjct: 89 AAKIINTKKLSARDHQK--LEREARICRLLKHPNIVRLHDSISEEGHHYLIF-DLVTGGE 145
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQN---VKLSD 468
L E ++ R E A +Q+ A+ + H++ + HRD+K EN+LL + VKL+D
Sbjct: 146 LFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLAD 205
Query: 469 FGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMP 528
FG A ++ + + F G+ Y +PE+L+ PY KP D+W+ G+++Y++L P
Sbjct: 206 FGLA---IEVEGEQQAWFGFAGTPGYLSPEVLRKDPY-GKPVDLWACGVILYILLVGYPP 261
Query: 529 FEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIA 588
F D+ +L+Q + F S DT++ K LI ML N R+ + + WI+
Sbjct: 262 FWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 321
Query: 589 MDSRLLE-WTPQETLAYKKAREEKNKLHKTVETVEL 623
S + QET+ K + KL + T L
Sbjct: 322 HRSTVASCMHRQETVDCLKKFNARRKLKGAILTTML 357
>M34181-1|AAA60170.1| 351|Homo sapiens cAMP-dependent protein
kinase catalytic subunit protein.
Length = 351
Score = 125 bits (301), Expect = 6e-28
Identities = 79/282 (28%), Positives = 148/282 (52%), Gaps = 21/282 (7%)
Query: 8 PSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKF 67
P++ N L + ++ K +G G++ +V L ++ + E + A KI++ K K ++
Sbjct: 34 PTQNNAGL-EDFERKKTLGTGSFGRVMLVKHKATEQYY----AMKILDKQKVVKLKQIEH 88
Query: 68 LPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWT 127
E +L +N P L+ + F+ + Y+ M Y G++ S++ + G SE AR +
Sbjct: 89 TLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYA 148
Query: 128 RQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGS 187
Q+ L +YLH L++ +RD+K EN+L+ ++++DFGF++ + T CG+
Sbjct: 149 AQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK------RVKGRTWTLCGT 202
Query: 188 MSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSR 247
Y APEI+ K Y K D W+LGV+++ M PF + ++YE+ + K RF S
Sbjct: 203 PEYLAPEIILSKGY-NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH 261
Query: 248 VASILSLECKTVVKHLLEPD-----PGLRHSATNVLDSEWIA 284
+S + K ++++LL+ D L++ +++ +W A
Sbjct: 262 FSS----DLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFA 299
Score = 102 bits (244), Expect = 5e-21
Identities = 63/236 (26%), Positives = 114/236 (48%), Gaps = 8/236 (3%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLL 413
A K++D + + E +L ++ P LV F+ ++ M Y+ G++
Sbjct: 71 AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMF 130
Query: 414 EFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFAR 473
+ + G E AR + Q+ L +Y+H L++ +RD+K EN+L+ ++++DFGFA
Sbjct: 131 SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFA- 189
Query: 474 MCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKH 533
K + R+ T CG+ Y APEI+ Y K D W+LG+++Y M PF
Sbjct: 190 -----KRVKGRTWTLCGTPEYLAPEIILSKGY-NKAVDWWALGVLIYEMAAGYPPFFADQ 243
Query: 534 IKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQN-RLKIYDIVNSEWIA 588
Q+++ ++ +F S + + D + L+ + L N + + DI +W A
Sbjct: 244 PIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFA 299
>DQ667174-1|ABG25919.1| 398|Homo sapiens protein kinase,
cAMP-dependent, catalytic, beta protein.
Length = 398
Score = 125 bits (301), Expect = 6e-28
Identities = 79/282 (28%), Positives = 148/282 (52%), Gaps = 21/282 (7%)
Query: 8 PSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKF 67
P++ N L + ++ K +G G++ +V L ++ + E + A KI++ K K ++
Sbjct: 81 PTQNNAGL-EDFERKKTLGTGSFGRVMLVKHKATEQYY----AMKILDKQKVVKLKQIEH 135
Query: 68 LPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWT 127
E +L +N P L+ + F+ + Y+ M Y G++ S++ + G SE AR +
Sbjct: 136 TLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYA 195
Query: 128 RQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGS 187
Q+ L +YLH L++ +RD+K EN+L+ ++++DFGF++ + T CG+
Sbjct: 196 AQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK------RVKGRTWTLCGT 249
Query: 188 MSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSR 247
Y APEI+ K Y K D W+LGV+++ M PF + ++YE+ + K RF S
Sbjct: 250 PEYLAPEIILSKGY-NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH 308
Query: 248 VASILSLECKTVVKHLLEPD-----PGLRHSATNVLDSEWIA 284
+S + K ++++LL+ D L++ +++ +W A
Sbjct: 309 FSS----DLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFA 346
Score = 102 bits (244), Expect = 5e-21
Identities = 63/236 (26%), Positives = 114/236 (48%), Gaps = 8/236 (3%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLL 413
A K++D + + E +L ++ P LV F+ ++ M Y+ G++
Sbjct: 118 AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMF 177
Query: 414 EFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFAR 473
+ + G E AR + Q+ L +Y+H L++ +RD+K EN+L+ ++++DFGFA
Sbjct: 178 SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFA- 236
Query: 474 MCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKH 533
K + R+ T CG+ Y APEI+ Y K D W+LG+++Y M PF
Sbjct: 237 -----KRVKGRTWTLCGTPEYLAPEIILSKGY-NKAVDWWALGVLIYEMAAGYPPFFADQ 290
Query: 534 IKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQN-RLKIYDIVNSEWIA 588
Q+++ ++ +F S + + D + L+ + L N + + DI +W A
Sbjct: 291 PIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFA 346
>BC040457-1|AAH40457.1| 478|Homo sapiens
calcium/calmodulin-dependent protein kinase (CaM kinase)
II alpha protein.
Length = 478
Score = 125 bits (301), Expect = 6e-28
Identities = 89/302 (29%), Positives = 144/302 (47%), Gaps = 13/302 (4%)
Query: 13 TLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREI 72
T T+ Y+L + +G+GA++ V + A KII T K K L RE
Sbjct: 7 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEY----AAKIINTKKLSARDHQK-LEREA 61
Query: 73 DVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLAL 132
+ L HP+++ +H + +Y+ G+L I+ SE A +Q+
Sbjct: 62 RICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILE 121
Query: 133 GLQYLHELEIAHRDIKCENVLLTANFN---VKLSDFGFSRFCVESDNQPVLSETYCGSMS 189
+ + H++ + HRD+K EN+LL + VKL+DFG + VE + Q + G+
Sbjct: 122 AVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLA-IEVEGEQQAWFG--FAGTPG 178
Query: 190 YAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVA 249
Y +PE+LR PY KP DLW+ GV+L+++L PF D +LY+Q Y F S
Sbjct: 179 YLSPEVLRKDPY-GKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEW 237
Query: 250 SILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRLTT-LNAVEAAALKRAKEDRR 308
++ E K ++ +L +P R +A L WI+ S + + ++ E + RR
Sbjct: 238 DTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARR 297
Query: 309 KL 310
KL
Sbjct: 298 KL 299
Score = 116 bits (278), Expect = 3e-25
Identities = 85/276 (30%), Positives = 138/276 (50%), Gaps = 13/276 (4%)
Query: 354 ACKVIDTST-APRDFVKKFLPREIEMLIKLSHPHLVHTH-SIFQRRYKYFIFMRYMERGD 411
A K+I+T + RD K L RE + L HP++V H SI + + Y IF + G+
Sbjct: 40 AAKIINTKKLSARDHQK--LEREARICRLLKHPNIVRLHDSISEEGHHYLIF-DLVTGGE 96
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQN---VKLSD 468
L E ++ R E A +Q+ A+ + H++ + HRD+K EN+LL + VKL+D
Sbjct: 97 LFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLAD 156
Query: 469 FGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMP 528
FG A ++ + + F G+ Y +PE+L+ PY KP D+W+ G+++Y++L P
Sbjct: 157 FGLA---IEVEGEQQAWFGFAGTPGYLSPEVLRKDPY-GKPVDLWACGVILYILLVGYPP 212
Query: 529 FEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIA 588
F D+ +L++ + F S DT++ K LI ML N R+ + + WI+
Sbjct: 213 FWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 272
Query: 589 MDSRLLE-WTPQETLAYKKAREEKNKLHKTVETVEL 623
S + QET+ K + KL + T L
Sbjct: 273 HRSTVASCMHRQETVDCLKKFNARRKLKGAILTTML 308
>AY633609-1|AAV33302.1| 672|Homo sapiens aging-associated gene 6
protein protein.
Length = 672
Score = 125 bits (301), Expect = 6e-28
Identities = 81/248 (32%), Positives = 128/248 (51%), Gaps = 13/248 (5%)
Query: 25 VGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRLNHP-HL 83
+G+G++ KV L + E+ + A KI++ +D V+ E VL L+ P L
Sbjct: 345 LGKGSFGKVMLADRKGTEELY----AIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFL 400
Query: 84 IHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLHELEIA 143
+HS FQ + Y M Y GDL+ +I + G E QA + ++++GL +LH+ I
Sbjct: 401 TQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGII 460
Query: 144 HRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRGKPYCP 203
+RD+K +NV+L + ++K++DFG C E V + T+CG+ Y APEI+ +PY
Sbjct: 461 YRDLKLDNVMLDSEGHIKIADFG---MCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPY-G 516
Query: 204 KPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKTVVKHL 263
K D W+ GV+L+ ML PFD +L++ M + LS E +V K L
Sbjct: 517 KSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSY----PKSLSKEAVSVCKGL 572
Query: 264 LEPDPGLR 271
+ P R
Sbjct: 573 MTKHPAKR 580
Score = 111 bits (268), Expect = 6e-24
Identities = 56/180 (31%), Positives = 98/180 (54%), Gaps = 4/180 (2%)
Query: 385 PHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHEL 444
P L HS FQ + + M Y+ GDL+ + Q G +E QA + ++++ + ++H+
Sbjct: 398 PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKR 457
Query: 445 EIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTP 504
I +RD+K +NV+L + ++K++DFG MC + ++ + + TFCG+ Y APEI+ P
Sbjct: 458 GIIYRDLKLDNVMLDSEGHIKIADFG---MCKEHMMDGVTTRTFCGTPDYIAPEIIAYQP 514
Query: 505 YLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLI 564
Y K D W+ G+++Y ML PF+ + +L Q+ + N + CK L+
Sbjct: 515 Y-GKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLM 573
>AL450063-3|CAI16846.1| 398|Homo sapiens protein kinase,
cAMP-dependent, catalytic, beta protein.
Length = 398
Score = 125 bits (301), Expect = 6e-28
Identities = 79/282 (28%), Positives = 148/282 (52%), Gaps = 21/282 (7%)
Query: 8 PSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKF 67
P++ N L + ++ K +G G++ +V L ++ + E + A KI++ K K ++
Sbjct: 81 PTQNNAGL-EDFERKKTLGTGSFGRVMLVKHKATEQYY----AMKILDKQKVVKLKQIEH 135
Query: 68 LPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWT 127
E +L +N P L+ + F+ + Y+ M Y G++ S++ + G SE AR +
Sbjct: 136 TLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYA 195
Query: 128 RQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGS 187
Q+ L +YLH L++ +RD+K EN+L+ ++++DFGF++ + T CG+
Sbjct: 196 AQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK------RVKGRTWTLCGT 249
Query: 188 MSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSR 247
Y APEI+ K Y K D W+LGV+++ M PF + ++YE+ + K RF S
Sbjct: 250 PEYLAPEIILSKGY-NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH 308
Query: 248 VASILSLECKTVVKHLLEPD-----PGLRHSATNVLDSEWIA 284
+S + K ++++LL+ D L++ +++ +W A
Sbjct: 309 FSS----DLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFA 346
Score = 102 bits (244), Expect = 5e-21
Identities = 63/236 (26%), Positives = 114/236 (48%), Gaps = 8/236 (3%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLL 413
A K++D + + E +L ++ P LV F+ ++ M Y+ G++
Sbjct: 118 AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMF 177
Query: 414 EFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFAR 473
+ + G E AR + Q+ L +Y+H L++ +RD+K EN+L+ ++++DFGFA
Sbjct: 178 SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFA- 236
Query: 474 MCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKH 533
K + R+ T CG+ Y APEI+ Y K D W+LG+++Y M PF
Sbjct: 237 -----KRVKGRTWTLCGTPEYLAPEIILSKGY-NKAVDWWALGVLIYEMAAGYPPFFADQ 290
Query: 534 IKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQN-RLKIYDIVNSEWIA 588
Q+++ ++ +F S + + D + L+ + L N + + DI +W A
Sbjct: 291 PIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFA 346
>AL450063-2|CAI16845.1| 351|Homo sapiens protein kinase,
cAMP-dependent, catalytic, beta protein.
Length = 351
Score = 125 bits (301), Expect = 6e-28
Identities = 79/282 (28%), Positives = 148/282 (52%), Gaps = 21/282 (7%)
Query: 8 PSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKF 67
P++ N L + ++ K +G G++ +V L ++ + E + A KI++ K K ++
Sbjct: 34 PTQNNAGL-EDFERKKTLGTGSFGRVMLVKHKATEQYY----AMKILDKQKVVKLKQIEH 88
Query: 68 LPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWT 127
E +L +N P L+ + F+ + Y+ M Y G++ S++ + G SE AR +
Sbjct: 89 TLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYA 148
Query: 128 RQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGS 187
Q+ L +YLH L++ +RD+K EN+L+ ++++DFGF++ + T CG+
Sbjct: 149 AQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK------RVKGRTWTLCGT 202
Query: 188 MSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSR 247
Y APEI+ K Y K D W+LGV+++ M PF + ++YE+ + K RF S
Sbjct: 203 PEYLAPEIILSKGY-NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH 261
Query: 248 VASILSLECKTVVKHLLEPD-----PGLRHSATNVLDSEWIA 284
+S + K ++++LL+ D L++ +++ +W A
Sbjct: 262 FSS----DLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFA 299
Score = 102 bits (244), Expect = 5e-21
Identities = 63/236 (26%), Positives = 114/236 (48%), Gaps = 8/236 (3%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLL 413
A K++D + + E +L ++ P LV F+ ++ M Y+ G++
Sbjct: 71 AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMF 130
Query: 414 EFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFAR 473
+ + G E AR + Q+ L +Y+H L++ +RD+K EN+L+ ++++DFGFA
Sbjct: 131 SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFA- 189
Query: 474 MCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKH 533
K + R+ T CG+ Y APEI+ Y K D W+LG+++Y M PF
Sbjct: 190 -----KRVKGRTWTLCGTPEYLAPEIILSKGY-NKAVDWWALGVLIYEMAAGYPPFFADQ 243
Query: 534 IKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQN-RLKIYDIVNSEWIA 588
Q+++ ++ +F S + + D + L+ + L N + + DI +W A
Sbjct: 244 PIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFA 299
>AL359504-2|CAI14541.1| 351|Homo sapiens protein kinase,
cAMP-dependent, catalytic, beta protein.
Length = 351
Score = 125 bits (301), Expect = 6e-28
Identities = 79/282 (28%), Positives = 148/282 (52%), Gaps = 21/282 (7%)
Query: 8 PSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKF 67
P++ N L + ++ K +G G++ +V L ++ + E + A KI++ K K ++
Sbjct: 34 PTQNNAGL-EDFERKKTLGTGSFGRVMLVKHKATEQYY----AMKILDKQKVVKLKQIEH 88
Query: 68 LPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWT 127
E +L +N P L+ + F+ + Y+ M Y G++ S++ + G SE AR +
Sbjct: 89 TLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYA 148
Query: 128 RQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGS 187
Q+ L +YLH L++ +RD+K EN+L+ ++++DFGF++ + T CG+
Sbjct: 149 AQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK------RVKGRTWTLCGT 202
Query: 188 MSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSR 247
Y APEI+ K Y K D W+LGV+++ M PF + ++YE+ + K RF S
Sbjct: 203 PEYLAPEIILSKGY-NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH 261
Query: 248 VASILSLECKTVVKHLLEPD-----PGLRHSATNVLDSEWIA 284
+S + K ++++LL+ D L++ +++ +W A
Sbjct: 262 FSS----DLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFA 299
Score = 102 bits (244), Expect = 5e-21
Identities = 63/236 (26%), Positives = 114/236 (48%), Gaps = 8/236 (3%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLL 413
A K++D + + E +L ++ P LV F+ ++ M Y+ G++
Sbjct: 71 AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMF 130
Query: 414 EFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFAR 473
+ + G E AR + Q+ L +Y+H L++ +RD+K EN+L+ ++++DFGFA
Sbjct: 131 SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFA- 189
Query: 474 MCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKH 533
K + R+ T CG+ Y APEI+ Y K D W+LG+++Y M PF
Sbjct: 190 -----KRVKGRTWTLCGTPEYLAPEIILSKGY-NKAVDWWALGVLIYEMAAGYPPFFADQ 243
Query: 534 IKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQN-RLKIYDIVNSEWIA 588
Q+++ ++ +F S + + D + L+ + L N + + DI +W A
Sbjct: 244 PIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFA 299
>AB209189-1|BAD92426.1| 365|Homo sapiens cAMP-dependent protein
kinase catalytic subunit beta isoform 2 variant protein.
Length = 365
Score = 125 bits (301), Expect = 6e-28
Identities = 79/282 (28%), Positives = 148/282 (52%), Gaps = 21/282 (7%)
Query: 8 PSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKF 67
P++ N L + ++ K +G G++ +V L ++ + E + A KI++ K K ++
Sbjct: 60 PTQNNAGL-EDFERKKTLGTGSFGRVMLVKHKATEQYY----AMKILDKQKVVKLKQIEH 114
Query: 68 LPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWT 127
E +L +N P L+ + F+ + Y+ M Y G++ S++ + G SE AR +
Sbjct: 115 TLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYA 174
Query: 128 RQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGS 187
Q+ L +YLH L++ +RD+K EN+L+ ++++DFGF++ + T CG+
Sbjct: 175 AQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK------RVKGRTWTLCGT 228
Query: 188 MSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSR 247
Y APEI+ K Y K D W+LGV+++ M PF + ++YE+ + K RF S
Sbjct: 229 PEYLAPEIILSKGY-NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH 287
Query: 248 VASILSLECKTVVKHLLEPD-----PGLRHSATNVLDSEWIA 284
+S + K ++++LL+ D L++ +++ +W A
Sbjct: 288 FSS----DLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFA 325
Score = 102 bits (244), Expect = 5e-21
Identities = 63/236 (26%), Positives = 114/236 (48%), Gaps = 8/236 (3%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLL 413
A K++D + + E +L ++ P LV F+ ++ M Y+ G++
Sbjct: 97 AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMF 156
Query: 414 EFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFAR 473
+ + G E AR + Q+ L +Y+H L++ +RD+K EN+L+ ++++DFGFA
Sbjct: 157 SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFA- 215
Query: 474 MCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKH 533
K + R+ T CG+ Y APEI+ Y K D W+LG+++Y M PF
Sbjct: 216 -----KRVKGRTWTLCGTPEYLAPEIILSKGY-NKAVDWWALGVLIYEMAAGYPPFFADQ 269
Query: 534 IKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQN-RLKIYDIVNSEWIA 588
Q+++ ++ +F S + + D + L+ + L N + + DI +W A
Sbjct: 270 PIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFA 325
>X52479-1|CAA36718.1| 672|Homo sapiens protein ( Human PKC alpha
mRNA for protein kinase C alpha. ).
Length = 672
Score = 124 bits (300), Expect = 8e-28
Identities = 80/248 (32%), Positives = 128/248 (51%), Gaps = 13/248 (5%)
Query: 25 VGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRLNHP-HL 83
+G+G++ KV L + E+ + A KI++ +D V+ E VL L+ P L
Sbjct: 345 LGKGSFGKVMLADRKGTEELY----AIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFL 400
Query: 84 IHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLHELEIA 143
+HS FQ + Y M Y GDL+ +I + G E QA + ++++GL +LH+ I
Sbjct: 401 TQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGII 460
Query: 144 HRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRGKPYCP 203
+RD+K +NV+L + ++K++DFG C E V + T+CG+ Y APEI+ +PY
Sbjct: 461 YRDLKLDNVMLDSEGHIKIADFG---MCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPY-G 516
Query: 204 KPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKTVVKHL 263
K D W+ GV+L+ ML PFD +L++ M + LS E ++ K L
Sbjct: 517 KSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSY----PKSLSKEAVSICKGL 572
Query: 264 LEPDPGLR 271
+ P R
Sbjct: 573 MTKHPAKR 580
Score = 111 bits (268), Expect = 6e-24
Identities = 56/180 (31%), Positives = 98/180 (54%), Gaps = 4/180 (2%)
Query: 385 PHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHEL 444
P L HS FQ + + M Y+ GDL+ + Q G +E QA + ++++ + ++H+
Sbjct: 398 PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKR 457
Query: 445 EIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTP 504
I +RD+K +NV+L + ++K++DFG MC + ++ + + TFCG+ Y APEI+ P
Sbjct: 458 GIIYRDLKLDNVMLDSEGHIKIADFG---MCKEHMMDGVTTRTFCGTPDYIAPEIIAYQP 514
Query: 505 YLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLI 564
Y K D W+ G+++Y ML PF+ + +L Q+ + N + CK L+
Sbjct: 515 Y-GKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLM 573
>BC109274-1|AAI09275.1| 672|Homo sapiens protein kinase C, alpha
protein.
Length = 672
Score = 124 bits (300), Expect = 8e-28
Identities = 80/248 (32%), Positives = 128/248 (51%), Gaps = 13/248 (5%)
Query: 25 VGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRLNHP-HL 83
+G+G++ KV L + E+ + A KI++ +D V+ E VL L+ P L
Sbjct: 345 LGKGSFGKVMLADRKGTEELY----AIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFL 400
Query: 84 IHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLHELEIA 143
+HS FQ + Y M Y GDL+ +I + G E QA + ++++GL +LH+ I
Sbjct: 401 TQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGII 460
Query: 144 HRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRGKPYCP 203
+RD+K +NV+L + ++K++DFG C E V + T+CG+ Y APEI+ +PY
Sbjct: 461 YRDLKLDNVMLDSEGHIKIADFG---MCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPY-G 516
Query: 204 KPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKTVVKHL 263
K D W+ GV+L+ ML PFD +L++ M + LS E ++ K L
Sbjct: 517 KSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSY----PKSLSKEAVSICKGL 572
Query: 264 LEPDPGLR 271
+ P R
Sbjct: 573 MTKHPAKR 580
Score = 111 bits (268), Expect = 6e-24
Identities = 56/180 (31%), Positives = 98/180 (54%), Gaps = 4/180 (2%)
Query: 385 PHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHEL 444
P L HS FQ + + M Y+ GDL+ + Q G +E QA + ++++ + ++H+
Sbjct: 398 PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKR 457
Query: 445 EIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTP 504
I +RD+K +NV+L + ++K++DFG MC + ++ + + TFCG+ Y APEI+ P
Sbjct: 458 GIIYRDLKLDNVMLDSEGHIKIADFG---MCKEHMMDGVTTRTFCGTPDYIAPEIIAYQP 514
Query: 505 YLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLI 564
Y K D W+ G+++Y ML PF+ + +L Q+ + N + CK L+
Sbjct: 515 Y-GKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLM 573
>BC109273-1|AAI09274.1| 672|Homo sapiens protein kinase C, alpha
protein.
Length = 672
Score = 124 bits (300), Expect = 8e-28
Identities = 80/248 (32%), Positives = 128/248 (51%), Gaps = 13/248 (5%)
Query: 25 VGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRLNHP-HL 83
+G+G++ KV L + E+ + A KI++ +D V+ E VL L+ P L
Sbjct: 345 LGKGSFGKVMLADRKGTEELY----AIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFL 400
Query: 84 IHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALGLQYLHELEIA 143
+HS FQ + Y M Y GDL+ +I + G E QA + ++++GL +LH+ I
Sbjct: 401 TQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGII 460
Query: 144 HRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEILRGKPYCP 203
+RD+K +NV+L + ++K++DFG C E V + T+CG+ Y APEI+ +PY
Sbjct: 461 YRDLKLDNVMLDSEGHIKIADFG---MCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPY-G 516
Query: 204 KPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLECKTVVKHL 263
K D W+ GV+L+ ML PFD +L++ M + LS E ++ K L
Sbjct: 517 KSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSY----PKSLSKEAVSICKGL 572
Query: 264 LEPDPGLR 271
+ P R
Sbjct: 573 MTKHPAKR 580
Score = 111 bits (268), Expect = 6e-24
Identities = 56/180 (31%), Positives = 98/180 (54%), Gaps = 4/180 (2%)
Query: 385 PHLVHTHSIFQRRYKYFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHEL 444
P L HS FQ + + M Y+ GDL+ + Q G +E QA + ++++ + ++H+
Sbjct: 398 PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKR 457
Query: 445 EIAHRDIKCENVLLTANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTP 504
I +RD+K +NV+L + ++K++DFG MC + ++ + + TFCG+ Y APEI+ P
Sbjct: 458 GIIYRDLKLDNVMLDSEGHIKIADFG---MCKEHMMDGVTTRTFCGTPDYIAPEIIAYQP 514
Query: 505 YLPKPTDVWSLGIVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLI 564
Y K D W+ G+++Y ML PF+ + +L Q+ + N + CK L+
Sbjct: 515 Y-GKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLM 573
>BC036023-1|AAH36023.1| 970|Homo sapiens polo-like kinase 4
(Drosophila) protein.
Length = 970
Score = 124 bits (299), Expect = 1e-27
Identities = 80/272 (29%), Positives = 140/272 (51%), Gaps = 17/272 (6%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKST-LACKIIETAKAPKDFVVKFLPREIDVLVR 77
+K+ +G+G++A VY E H +A K+I+ K +V+ + E+ + +
Sbjct: 12 FKVGNLLGKGSFAGVYRAE-----SIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQ 66
Query: 78 LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGC--VSENQARVWTRQLALGLQ 135
L HP ++ +++ F+ Y+ + NG++ Y LKN SEN+AR + Q+ G+
Sbjct: 67 LKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRY-LKNRVKPFSENEARHFMHQIITGML 125
Query: 136 YLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEI 195
YLH I HRD+ N+LLT N N+K++DFG + + T CG+ +Y +PEI
Sbjct: 126 YLHSHGILHRDLTLSNLLLTRNMNIKIADFGLA---TQLKMPHEKHYTLCGTPNYISPEI 182
Query: 196 LRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLE 255
+ +D+WSLG + + +L PFD ++ + + Y + S LS+E
Sbjct: 183 ATRSAH-GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADY----EMPSFLSIE 237
Query: 256 CKTVVKHLLEPDPGLRHSATNVLDSEWIAMDS 287
K ++ LL +P R S ++VLD +++ +S
Sbjct: 238 AKDLIHQLLRRNPADRLSLSSVLDHPFMSRNS 269
Score = 101 bits (243), Expect = 6e-21
Identities = 65/252 (25%), Positives = 126/252 (50%), Gaps = 10/252 (3%)
Query: 341 YRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKY 400
YR S + L + A K+ID + + + + E+++ +L HP ++ ++ F+
Sbjct: 27 YRAESIHTGLEV-AIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYV 85
Query: 401 FIFMRYMERGDLLEFVLQR-GAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLT 459
++ + G++ ++ R E++AR + Q+ + Y+H I HRD+ N+LLT
Sbjct: 86 YLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLT 145
Query: 460 ANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVV 519
N N+K++DFG A K+ + T CG+ +Y +PEI + + +DVWSLG +
Sbjct: 146 RNMNIKIADFGLA---TQLKMPHEKHYTLCGTPNYISPEIATRSAH-GLESDVWSLGCMF 201
Query: 520 YVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIY 579
Y +L PF+ +K + +++ S +S K LI +L N +RL +
Sbjct: 202 YTLLIGRPPFDTDTVKNTLNKVVLADYEMPS----FLSIEAKDLIHQLLRRNPADRLSLS 257
Query: 580 DIVNSEWIAMDS 591
+++ +++ +S
Sbjct: 258 SVLDHPFMSRNS 269
>AK000231-1|BAA91023.1| 244|Homo sapiens protein ( Homo sapiens
cDNA FLJ20224 fis, clone COLF5039. ).
Length = 244
Score = 124 bits (298), Expect = 1e-27
Identities = 78/242 (32%), Positives = 127/242 (52%), Gaps = 17/242 (7%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREIDVLVRL 78
Y L K +G G +A V L + + +A K+I+ K L +E+ + +
Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEK----VAVKVIDKTKLDT-LATGHLFQEVRCMKLV 70
Query: 79 NHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNG-CVSENQARVWTRQLALGLQYL 137
HP+++ ++ + +TK Y+ + + GD+ YI+K+ ++E+ A+ + Q+ + Y
Sbjct: 71 QHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYC 130
Query: 138 HELEIAHRDIKCENVLLTANFN-VKLSDFGFSRFCVESDNQPVLS-ETYCGSMSYAAPEI 195
H+L + HRD+K ENV+ VKL+DFGFS + QP T CGS++Y+APEI
Sbjct: 131 HKLHVVHRDLKPENVVFFEKQGLVKLTDFGFS-----NKFQPGKKLTTSCGSLAYSAPEI 185
Query: 196 LRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLE 255
L G Y D+WSLGV+LF+++ + PF + + M KY V S +S E
Sbjct: 186 LLGDEYDAPAVDIWSLGVILFMLVCEQPPFQEANDSETLTMIMDCKY----TVPSHVSKE 241
Query: 256 CK 257
CK
Sbjct: 242 CK 243
Score = 112 bits (270), Expect = 3e-24
Identities = 61/182 (33%), Positives = 104/182 (57%), Gaps = 9/182 (4%)
Query: 353 LACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDL 412
+A KVID T L +E+ + + HP++V + + + K ++ + + GD+
Sbjct: 42 VAVKVID-KTKLDTLATGHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDM 100
Query: 413 LEFVLQRG-AVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQN-VKLSDFG 470
+++++ + ED A+ + Q+ AI Y H+L + HRD+K ENV+ Q VKL+DFG
Sbjct: 101 FDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFG 160
Query: 471 FA-RMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPF 529
F+ + KKL T CGSL+Y+APEIL G Y D+WSLG+++++++ PF
Sbjct: 161 FSNKFQPGKKLT-----TSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCEQPPF 215
Query: 530 ED 531
++
Sbjct: 216 QE 217
>D84212-1|BAA23592.1| 402|Homo sapiens aurora/IPL1-related kinase
protein.
Length = 402
Score = 123 bits (297), Expect = 2e-27
Identities = 75/279 (26%), Positives = 137/279 (49%), Gaps = 14/279 (5%)
Query: 9 SEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFL 68
+++ + + +++ + +G+G + VYL ++E K LA K++ A+ K V L
Sbjct: 122 NQKEAVALEDFEIGRPLGKGKFGNVYL----AREKQSKFILALKVLFKAQLEKAGVEHQL 177
Query: 69 PREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTR 128
RE+++ L HP+++ ++ F T+ Y+ + Y G + + K E +
Sbjct: 178 RREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTANLYN 237
Query: 129 QLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSM 188
++A L Y H + HRDIK EN+LL + +K++DFG+S S T CG++
Sbjct: 238 RIANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRR-----TTLCGTL 292
Query: 189 SYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRV 248
Y PE++ G+ + K DLWSLGV+ + L PF+ ++ Y++ ++ F V
Sbjct: 293 DYLPPEMIEGRMHDEK-VDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFV 351
Query: 249 ASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDS 287
+ ++ LL+ +P R VL+ WI +S
Sbjct: 352 TE----GARDLISRLLKHNPSQRPMLREVLEHPWITANS 386
Score = 106 bits (254), Expect = 3e-22
Identities = 67/251 (26%), Positives = 119/251 (47%), Gaps = 11/251 (4%)
Query: 341 YRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKY 400
Y K K ILA KV+ + + V+ L RE+E+ L HP+++ + F +
Sbjct: 147 YLAREKQSKF-ILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRV 205
Query: 401 FIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTA 460
++ + Y G + + + E + ++A A+ Y H + HRDIK EN+LL +
Sbjct: 206 YLILEYAPLGTVYRELQKLSKFDEQRTANLYNRIANALSYCHSKRVIHRDIKPENLLLGS 265
Query: 461 NQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVY 520
+K++DFG++ R T CG+L Y PE+++G + K D+WSLG++ Y
Sbjct: 266 AGELKIADFGWSVHAPSS-----RRTTLCGTLDYLPPEMIEGRMHDEK-VDLWSLGVLCY 319
Query: 521 VMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYD 580
L PFE +Q + + + D +++ + LI +L+ N R + +
Sbjct: 320 EFLVGKPPFE----ANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLRE 375
Query: 581 IVNSEWIAMDS 591
++ WI +S
Sbjct: 376 VLEHPWITANS 386
>BC022558-1|AAH22558.1| 344|Homo sapiens CAMK2D protein protein.
Length = 344
Score = 123 bits (297), Expect = 2e-27
Identities = 88/302 (29%), Positives = 143/302 (47%), Gaps = 13/302 (4%)
Query: 13 TLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREI 72
T T Y+L + +G+GA++ V + A KII T K K L RE
Sbjct: 8 TRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEY----AAKIINTKKLSARDHQK-LEREA 62
Query: 73 DVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLAL 132
+ L HP+++ +H + +Y+ G+L I+ SE A +Q+
Sbjct: 63 RICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILE 122
Query: 133 GLQYLHELEIAHRDIKCENVLLTANFN---VKLSDFGFSRFCVESDNQPVLSETYCGSMS 189
+ + H++ + HRD+K EN+LL + VKL+DFG + V+ D Q + G+
Sbjct: 123 AVLHCHQMGVVHRDLKPENLLLASKSKGAAVKLADFGLA-IEVQGDQQAWFG--FAGTPG 179
Query: 190 YAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVA 249
Y +PE+LR PY KP D+W+ GV+L+++L PF D +LY+Q Y F S
Sbjct: 180 YLSPEVLRKDPY-GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEW 238
Query: 250 SILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSRLTT-LNAVEAAALKRAKEDRR 308
++ E K ++ +L +P R +A+ L WI S + + ++ E + RR
Sbjct: 239 DTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARR 298
Query: 309 KL 310
KL
Sbjct: 299 KL 300
Score = 121 bits (292), Expect = 7e-27
Identities = 91/298 (30%), Positives = 147/298 (49%), Gaps = 15/298 (5%)
Query: 354 ACKVIDTST-APRDFVKKFLPREIEMLIKLSHPHLVHTH-SIFQRRYKYFIFMRYMERGD 411
A K+I+T + RD K L RE + L HP++V H SI + + Y +F + G+
Sbjct: 41 AAKIINTKKLSARDHQK--LEREARICRLLKHPNIVRLHDSISEEGFHYLVF-DLVTGGE 97
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQN---VKLSD 468
L E ++ R E A +Q+ A+ + H++ + HRD+K EN+LL + VKL+D
Sbjct: 98 LFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKSKGAAVKLAD 157
Query: 469 FGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMP 528
FG A ++ + ++ F G+ Y +PE+L+ PY KP D+W+ G+++Y++L P
Sbjct: 158 FGLA---IEVQGDQQAWFGFAGTPGYLSPEVLRKDPY-GKPVDMWACGVILYILLVGYPP 213
Query: 529 FEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIA 588
F D+ +L+Q + F S DT++ K LI ML N R+ + + WI
Sbjct: 214 FWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWIC 273
Query: 589 MDSRLLEWT-PQETLAYKKAREEKNKLHKTVETVELPGSSKTEHKVCL--PDSLVENN 643
S + QET+ K + KL + T L + + K L PD + NN
Sbjct: 274 QRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKINN 331
>AB006972-1|BAB69958.1| 970|Homo sapiens Sak protein.
Length = 970
Score = 123 bits (297), Expect = 2e-27
Identities = 79/272 (29%), Positives = 140/272 (51%), Gaps = 17/272 (6%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKST-LACKIIETAKAPKDFVVKFLPREIDVLVR 77
+K+ +G+G++A VY E H +A K+I+ K +V+ + E+ + +
Sbjct: 12 FKVGNLLGKGSFAGVYRAE-----SIHSGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQ 66
Query: 78 LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGC--VSENQARVWTRQLALGLQ 135
L HP ++ +++ F+ Y+ + NG++ Y LKN SEN+AR + Q+ G+
Sbjct: 67 LKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRY-LKNRVKPFSENEARHFMHQIITGML 125
Query: 136 YLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEI 195
YLH I HRD+ N+LLT N N+K++DFG + + T CG+ +Y +PEI
Sbjct: 126 YLHSHGILHRDLTLSNLLLTRNMNIKIADFGLA---TQLKMPHEKHYTLCGTPNYISPEI 182
Query: 196 LRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLE 255
+ +D+WSLG + + +L PFD ++ + + Y + + LS+E
Sbjct: 183 ATRSAH-GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADY----EMPTFLSIE 237
Query: 256 CKTVVKHLLEPDPGLRHSATNVLDSEWIAMDS 287
K ++ LL +P R S ++VLD +++ +S
Sbjct: 238 AKDLIHQLLRRNPADRLSLSSVLDHPFMSRNS 269
Score = 101 bits (241), Expect = 1e-20
Identities = 64/252 (25%), Positives = 126/252 (50%), Gaps = 10/252 (3%)
Query: 341 YRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKY 400
YR S + L + A K+ID + + + + E+++ +L HP ++ ++ F+
Sbjct: 27 YRAESIHSGLEV-AIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYV 85
Query: 401 FIFMRYMERGDLLEFVLQR-GAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLT 459
++ + G++ ++ R E++AR + Q+ + Y+H I HRD+ N+LLT
Sbjct: 86 YLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLT 145
Query: 460 ANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVV 519
N N+K++DFG A K+ + T CG+ +Y +PEI + + +DVWSLG +
Sbjct: 146 RNMNIKIADFGLA---TQLKMPHEKHYTLCGTPNYISPEIATRSAH-GLESDVWSLGCMF 201
Query: 520 YVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIY 579
Y +L PF+ +K + +++ + +S K LI +L N +RL +
Sbjct: 202 YTLLIGRPPFDTDTVKNTLNKVVLADYEMPT----FLSIEAKDLIHQLLRRNPADRLSLS 257
Query: 580 DIVNSEWIAMDS 591
+++ +++ +S
Sbjct: 258 SVLDHPFMSRNS 269
>Y13115-1|CAA73575.1| 970|Homo sapiens serine/threonine protein
kinase protein.
Length = 970
Score = 123 bits (296), Expect = 2e-27
Identities = 79/272 (29%), Positives = 140/272 (51%), Gaps = 17/272 (6%)
Query: 19 YKLTKFVGEGAYAKVYLTEYSSKEDSHKST-LACKIIETAKAPKDFVVKFLPREIDVLVR 77
+K+ +G+G++A VY E H +A K+I+ K +V+ + E+ + +
Sbjct: 12 FKVGNLLGKGSFAGVYRAE-----SIHTGLEVAIKMIDKKAMYKAGMVQRVKNEVKIHCQ 66
Query: 78 LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGC--VSENQARVWTRQLALGLQ 135
L HP ++ +++ F+ Y+ + NG++ Y LKN SEN+AR + Q+ G+
Sbjct: 67 LKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRY-LKNRVKPFSENEARHFMHQIITGML 125
Query: 136 YLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAPEI 195
YLH I HRD+ N+LLT N N+K++DFG + + T CG+ +Y +PEI
Sbjct: 126 YLHSHGILHRDLTLSNLLLTRNMNIKIADFGLA---TQLKMPHEKHYTLCGTPNYISPEI 182
Query: 196 LRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILSLE 255
+ +D+WSLG + + +L PFD ++ + + Y + + LS+E
Sbjct: 183 ATRSAH-GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADY----EMPTFLSIE 237
Query: 256 CKTVVKHLLEPDPGLRHSATNVLDSEWIAMDS 287
K ++ LL +P R S ++VLD +++ +S
Sbjct: 238 AKDLIHQLLRRNPADRLSLSSVLDHPFMSRNS 269
Score = 100 bits (240), Expect = 1e-20
Identities = 64/252 (25%), Positives = 126/252 (50%), Gaps = 10/252 (3%)
Query: 341 YRNASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKY 400
YR S + L + A K+ID + + + + E+++ +L HP ++ ++ F+
Sbjct: 27 YRAESIHTGLEV-AIKMIDKKAMYKAGMVQRVKNEVKIHCQLKHPSILELYNYFEDSNYV 85
Query: 401 FIFMRYMERGDLLEFVLQR-GAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLT 459
++ + G++ ++ R E++AR + Q+ + Y+H I HRD+ N+LLT
Sbjct: 86 YLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLT 145
Query: 460 ANQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVV 519
N N+K++DFG A K+ + T CG+ +Y +PEI + + +DVWSLG +
Sbjct: 146 RNMNIKIADFGLA---TQLKMPHEKHYTLCGTPNYISPEIATRSAH-GLESDVWSLGCMF 201
Query: 520 YVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIY 579
Y +L PF+ +K + +++ + +S K LI +L N +RL +
Sbjct: 202 YTLLIGRPPFDTDTVKNTLNKVVLADYEMPT----FLSIEAKDLIHQLLRRNPADRLSLS 257
Query: 580 DIVNSEWIAMDS 591
+++ +++ +S
Sbjct: 258 SVLDHPFMSRNS 269
>BT020098-1|AAV38901.1| 367|Homo sapiens serum/glucocorticoid
regulated kinase 2 protein.
Length = 367
Score = 123 bits (296), Expect = 2e-27
Identities = 73/229 (31%), Positives = 116/229 (50%), Gaps = 9/229 (3%)
Query: 8 PSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKF 67
PS + K +G+G Y KV L +K S + A K+++ K
Sbjct: 24 PSANPNAQPTDFDFLKVIGKGNYGKVLL----AKRKSDGAFYAVKVLQKKSILKKKEQSH 79
Query: 68 LPREIDVLVR-LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVW 126
+ E VL++ + HP L+ + FQ K Y + Y G+L ++ + E +AR +
Sbjct: 80 IMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFY 139
Query: 127 TRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCG 186
++A + YLH L I +RD+K EN+LL +V L+DFG + VE ++ + T+CG
Sbjct: 140 AAEVASAIDYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPED---TTSTFCG 196
Query: 187 SMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYE 235
+ Y APE+LR +PY + D W LG VL+ ML+ PF + ++YE
Sbjct: 197 TPEYLAPEVLRKEPY-DRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYE 244
Score = 109 bits (263), Expect = 2e-23
Identities = 63/197 (31%), Positives = 103/197 (52%), Gaps = 5/197 (2%)
Query: 344 ASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIK-LSHPHLVHTHSIFQRRYKYFI 402
A + + A KV+ + + + + E +L+K + HP LV FQ K +
Sbjct: 52 AKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYF 111
Query: 403 FMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQ 462
+ Y+ G+L + + E +AR + ++A AI Y+H L I +RD+K EN+LL
Sbjct: 112 VLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIDYLHSLNIIYRDLKPENILLDCQG 171
Query: 463 NVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVM 522
+V L+DFG +C + E + TFCG+ Y APE+L+ PY + D W LG V+Y M
Sbjct: 172 HVVLTDFG---LCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPY-DRAVDWWCLGAVLYEM 227
Query: 523 LNRAMPFEDKHIKQLHQ 539
L+ PF + + Q+++
Sbjct: 228 LHGLPPFYSQDVSQMYE 244
>BC035058-1|AAH35058.1| 351|Homo sapiens protein kinase,
cAMP-dependent, catalytic, beta protein.
Length = 351
Score = 123 bits (296), Expect = 2e-27
Identities = 79/282 (28%), Positives = 148/282 (52%), Gaps = 21/282 (7%)
Query: 8 PSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKF 67
P++ N L + ++ K +G G++ +V L ++ + E + A KI++ K K ++
Sbjct: 34 PTQNNAGL-EDFERKKTLGTGSFGRVMLVKHKATEQYY----AMKILDKQKVVKLKQIEH 88
Query: 68 LPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWT 127
E +L +N P L+ + F+ + Y+ M Y G++ S++ + G SE AR +
Sbjct: 89 TLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYA 148
Query: 128 RQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGS 187
Q+ L +YL+ L+I +RD+K EN+L+ ++++DFGF++ + T CG+
Sbjct: 149 AQIVLTFEYLNSLDIIYRDLKPENLLIDHQGYIQVTDFGFAK------RVKGRTWTLCGT 202
Query: 188 MSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSR 247
Y APEI+ K Y K D W+LGV+++ M PF + ++YE+ + K RF S
Sbjct: 203 PEYLAPEIILSKGY-NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSN 261
Query: 248 VASILSLECKTVVKHLLEPD-----PGLRHSATNVLDSEWIA 284
+S + K ++++LL+ D L++ +++ +W A
Sbjct: 262 FSS----DLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFA 299
Score = 100 bits (239), Expect = 2e-20
Identities = 63/236 (26%), Positives = 114/236 (48%), Gaps = 8/236 (3%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLL 413
A K++D + + E +L ++ P LV F+ ++ M Y+ G++
Sbjct: 71 AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMF 130
Query: 414 EFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFAR 473
+ + G E AR + Q+ L +Y++ L+I +RD+K EN+L+ ++++DFGFA
Sbjct: 131 SHLRRIGRFSEPHARFYAAQIVLTFEYLNSLDIIYRDLKPENLLIDHQGYIQVTDFGFA- 189
Query: 474 MCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKH 533
K + R+ T CG+ Y APEI+ Y K D W+LG+++Y M PF
Sbjct: 190 -----KRVKGRTWTLCGTPEYLAPEIILSKGY-NKAVDWWALGVLIYEMAAGYPPFFADQ 243
Query: 534 IKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQN-RLKIYDIVNSEWIA 588
Q+++ ++ +F S + + D + L+ + L N + + DI +W A
Sbjct: 244 PIQIYEKIVSGKVRFPSNFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFA 299
>AF415197-1|AAM33514.1| 566|Homo sapiens
calcium/calmodulin-dependent protein kinase II gamma
protein.
Length = 566
Score = 123 bits (296), Expect = 2e-27
Identities = 80/265 (30%), Positives = 126/265 (47%), Gaps = 9/265 (3%)
Query: 50 ACKIIETAKAPKDFVVKFLPREIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLL 109
A KII T K K L RE + L HP+++ +H + +Y+ G+L
Sbjct: 19 AAKIINTKKLSARDHQK-LEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELF 77
Query: 110 SYILKNGCVSENQARVWTRQLALGLQYLHELEIAHRDIKCENVLLTANFN---VKLSDFG 166
I+ SE A Q+ + ++H+ +I HRD+K EN+LL + VKL+DFG
Sbjct: 78 EDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFG 137
Query: 167 FSRFCVESDNQPVLSETYCGSMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFD 226
+ +E + + G+ Y +PE+LR PY KP D+W+ GV+L+++L PF
Sbjct: 138 LA---IEVQGEQQAWFGFAGTPGYLSPEVLRKDPY-GKPVDIWACGVILYILLVGYPPFW 193
Query: 227 DTRMRKLYEQQMGKKYRFRSRVASILSLECKTVVKHLLEPDPGLRHSATNVLDSEWIAMD 286
D KLY+Q Y F S ++ E K ++ +L +P R +A L W+
Sbjct: 194 DEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQR 253
Query: 287 SRLTT-LNAVEAAALKRAKEDRRKL 310
S + + ++ E R RRKL
Sbjct: 254 STVASMMHRQETVECLRKFNARRKL 278
Score = 117 bits (282), Expect = 1e-25
Identities = 85/288 (29%), Positives = 138/288 (47%), Gaps = 13/288 (4%)
Query: 342 RNASKNDKLSILACKVIDTST-APRDFVKKFLPREIEMLIKLSHPHLVHTH-SIFQRRYK 399
R K A K+I+T + RD K L RE + L HP++V H SI + +
Sbjct: 7 RRCVKKTSTQEYAAKIINTKKLSARDHQK--LEREARICRLLKHPNIVRLHDSISEEGFH 64
Query: 400 YFIFMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLT 459
Y +F + G+L E ++ R E A Q+ ++ ++H+ +I HRD+K EN+LL
Sbjct: 65 YLVF-DLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLA 123
Query: 460 A---NQNVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLG 516
+ VKL+DFG A ++ + + F G+ Y +PE+L+ PY KP D+W+ G
Sbjct: 124 SKCKGAAVKLADFGLA---IEVQGEQQAWFGFAGTPGYLSPEVLRKDPY-GKPVDIWACG 179
Query: 517 IVVYVMLNRAMPFEDKHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRL 576
+++Y++L PF D+ +L+Q + F S DT++ K LI ML N R+
Sbjct: 180 VILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRI 239
Query: 577 KIYDIVNSEWIAMDSRLLEWT-PQETLAYKKAREEKNKLHKTVETVEL 623
+ W+ S + QET+ + + KL + T L
Sbjct: 240 TADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTML 287
>X07767-1|CAA30597.1| 351|Homo sapiens protein ( Human mRNA for
cAMP-dependent protein kinase catalytic subunit type
alpha (EC 2.7.1.37). ).
Length = 351
Score = 122 bits (295), Expect = 3e-27
Identities = 77/279 (27%), Positives = 144/279 (51%), Gaps = 20/279 (7%)
Query: 11 ENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPR 70
+NT ++ K +G G++ +V L ++ + + A KI++ K K ++
Sbjct: 36 QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHY----AMKILDKQKVVKLKQIEHTLN 91
Query: 71 EIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQL 130
E +L +N P L+ + F+ + Y+ M Y G++ S++ + G SE AR + Q+
Sbjct: 92 EKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 151
Query: 131 ALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSY 190
L +YLH L++ +RD+K EN+L+ ++++DFGF++ + T CG+ Y
Sbjct: 152 VLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK------RVKGRTWTLCGTPEY 205
Query: 191 AAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVAS 250
APEI+ K Y K D W+LGV+++ M PF + ++YE+ + K RF S +S
Sbjct: 206 LAPEIILSKGY-NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSS 264
Query: 251 ILSLECKTVVKHLLEPD-----PGLRHSATNVLDSEWIA 284
+ K ++++LL+ D L++ ++ + +W A
Sbjct: 265 ----DLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299
Score = 104 bits (249), Expect = 1e-21
Identities = 64/236 (27%), Positives = 115/236 (48%), Gaps = 8/236 (3%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLL 413
A K++D + + E +L ++ P LV F+ ++ M Y+ G++
Sbjct: 71 AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMF 130
Query: 414 EFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFAR 473
+ + G E AR + Q+ L +Y+H L++ +RD+K EN+L+ ++++DFGFA
Sbjct: 131 SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFA- 189
Query: 474 MCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKH 533
K + R+ T CG+ Y APEI+ Y K D W+LG+++Y M PF
Sbjct: 190 -----KRVKGRTWTLCGTPEYLAPEIILSKGY-NKAVDWWALGVLIYEMAAGYPPFFADQ 243
Query: 534 IKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQN-RLKIYDIVNSEWIA 588
Q+++ ++ +F S + + D + L+ + L N + + DI N +W A
Sbjct: 244 PIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299
>DQ667173-1|ABG25918.1| 351|Homo sapiens protein kinase,
cAMP-dependent, catalytic, alpha protein.
Length = 351
Score = 122 bits (295), Expect = 3e-27
Identities = 77/279 (27%), Positives = 144/279 (51%), Gaps = 20/279 (7%)
Query: 11 ENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPR 70
+NT ++ K +G G++ +V L ++ + + A KI++ K K ++
Sbjct: 36 QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHY----AMKILDKQKVVKLKQIEHTLN 91
Query: 71 EIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQL 130
E +L +N P L+ + F+ + Y+ M Y G++ S++ + G SE AR + Q+
Sbjct: 92 EKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 151
Query: 131 ALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSY 190
L +YLH L++ +RD+K EN+L+ ++++DFGF++ + T CG+ Y
Sbjct: 152 VLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK------RVKGRTWTLCGTPEY 205
Query: 191 AAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVAS 250
APEI+ K Y K D W+LGV+++ M PF + ++YE+ + K RF S +S
Sbjct: 206 LAPEIILSKGY-NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSS 264
Query: 251 ILSLECKTVVKHLLEPD-----PGLRHSATNVLDSEWIA 284
+ K ++++LL+ D L++ ++ + +W A
Sbjct: 265 ----DLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299
Score = 104 bits (249), Expect = 1e-21
Identities = 64/236 (27%), Positives = 115/236 (48%), Gaps = 8/236 (3%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLL 413
A K++D + + E +L ++ P LV F+ ++ M Y+ G++
Sbjct: 71 AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMF 130
Query: 414 EFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFAR 473
+ + G E AR + Q+ L +Y+H L++ +RD+K EN+L+ ++++DFGFA
Sbjct: 131 SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFA- 189
Query: 474 MCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKH 533
K + R+ T CG+ Y APEI+ Y K D W+LG+++Y M PF
Sbjct: 190 -----KRVKGRTWTLCGTPEYLAPEIILSKGY-NKAVDWWALGVLIYEMAAGYPPFFADQ 243
Query: 534 IKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQN-RLKIYDIVNSEWIA 588
Q+++ ++ +F S + + D + L+ + L N + + DI N +W A
Sbjct: 244 PIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299
>BC108259-1|AAI08260.1| 351|Homo sapiens protein kinase,
cAMP-dependent, catalytic, alpha protein.
Length = 351
Score = 122 bits (295), Expect = 3e-27
Identities = 77/279 (27%), Positives = 144/279 (51%), Gaps = 20/279 (7%)
Query: 11 ENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPR 70
+NT ++ K +G G++ +V L ++ + + A KI++ K K ++
Sbjct: 36 QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHY----AMKILDKQKVVKLKQIEHTLN 91
Query: 71 EIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQL 130
E +L +N P L+ + F+ + Y+ M Y G++ S++ + G SE AR + Q+
Sbjct: 92 EKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 151
Query: 131 ALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSY 190
L +YLH L++ +RD+K EN+L+ ++++DFGF++ + T CG+ Y
Sbjct: 152 VLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK------RVKGRTWTLCGTPEY 205
Query: 191 AAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVAS 250
APEI+ K Y K D W+LGV+++ M PF + ++YE+ + K RF S +S
Sbjct: 206 LAPEIILSKGY-NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSS 264
Query: 251 ILSLECKTVVKHLLEPD-----PGLRHSATNVLDSEWIA 284
+ K ++++LL+ D L++ ++ + +W A
Sbjct: 265 ----DLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299
Score = 104 bits (249), Expect = 1e-21
Identities = 64/236 (27%), Positives = 115/236 (48%), Gaps = 8/236 (3%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLL 413
A K++D + + E +L ++ P LV F+ ++ M Y+ G++
Sbjct: 71 AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMF 130
Query: 414 EFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFAR 473
+ + G E AR + Q+ L +Y+H L++ +RD+K EN+L+ ++++DFGFA
Sbjct: 131 SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFA- 189
Query: 474 MCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKH 533
K + R+ T CG+ Y APEI+ Y K D W+LG+++Y M PF
Sbjct: 190 -----KRVKGRTWTLCGTPEYLAPEIILSKGY-NKAVDWWALGVLIYEMAAGYPPFFADQ 243
Query: 534 IKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQN-RLKIYDIVNSEWIA 588
Q+++ ++ +F S + + D + L+ + L N + + DI N +W A
Sbjct: 244 PIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299
>BC075064-1|AAH75064.2| 275|Homo sapiens AURKC protein protein.
Length = 275
Score = 122 bits (295), Expect = 3e-27
Identities = 75/275 (27%), Positives = 138/275 (50%), Gaps = 14/275 (5%)
Query: 14 LLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREID 73
L +++ + +G+G + VYL ++SH +A K++ ++ K+ + L REI+
Sbjct: 4 LTVDDFEIGRPLGKGKFGNVYLARL---KESH-FIVALKVLFKSQIEKEGLEHQLRREIE 59
Query: 74 VLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALG 133
+ L HP+++ +++ F + Y+ + Y G+L + K+ + E + +LA
Sbjct: 60 IQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADA 119
Query: 134 LQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAP 193
L Y H+ ++ HRDIK EN+LL VK++DFG+S V + + + +T CG++ Y P
Sbjct: 120 LTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWS---VHTPS--LRRKTMCGTLDYLPP 174
Query: 194 EILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILS 253
E++ G+ Y K DLW +GV+ + +L PF+ + Y + + RF +
Sbjct: 175 EMIEGRTYDEK-VDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRF----PLSMP 229
Query: 254 LECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSR 288
L + ++ LL P R +L W+ SR
Sbjct: 230 LGARDLISRLLRYQPLERLPLAQILKHPWVQAHSR 264
Score = 114 bits (275), Expect = 8e-25
Identities = 69/241 (28%), Positives = 121/241 (50%), Gaps = 10/241 (4%)
Query: 352 ILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
I+A KV+ S ++ ++ L REIE+ L HP+++ ++ F + ++ + Y RG+
Sbjct: 34 IVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGE 93
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
L + + + + E + +LA A+ Y H+ ++ HRDIK EN+LL VK++DFG+
Sbjct: 94 LYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGW 153
Query: 472 ARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFED 531
+ +R +T CG+L Y PE+++G Y K D+W +G++ Y +L PFE
Sbjct: 154 S-----VHTPSLRRKTMCGTLDYLPPEMIEGRTYDEK-VDLWCIGVLCYELLVGYPPFES 207
Query: 532 KHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDS 591
H + K R+ ++ + LI +L RL + I+ W+ S
Sbjct: 208 AS----HSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHS 263
Query: 592 R 592
R
Sbjct: 264 R 264
>BC039846-1|AAH39846.1| 351|Homo sapiens protein kinase,
cAMP-dependent, catalytic, alpha protein.
Length = 351
Score = 122 bits (295), Expect = 3e-27
Identities = 77/279 (27%), Positives = 144/279 (51%), Gaps = 20/279 (7%)
Query: 11 ENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPR 70
+NT ++ K +G G++ +V L ++ + + A KI++ K K ++
Sbjct: 36 QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHY----AMKILDKQKVVKLKQIEHTLN 91
Query: 71 EIDVLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQL 130
E +L +N P L+ + F+ + Y+ M Y G++ S++ + G SE AR + Q+
Sbjct: 92 EKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 151
Query: 131 ALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSY 190
L +YLH L++ +RD+K EN+L+ ++++DFGF++ + T CG+ Y
Sbjct: 152 VLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK------RVKGRTWTLCGTPEY 205
Query: 191 AAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVAS 250
APEI+ K Y K D W+LGV+++ M PF + ++YE+ + K RF S +S
Sbjct: 206 LAPEIILSKGY-NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSS 264
Query: 251 ILSLECKTVVKHLLEPD-----PGLRHSATNVLDSEWIA 284
+ K ++++LL+ D L++ ++ + +W A
Sbjct: 265 ----DLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299
Score = 104 bits (249), Expect = 1e-21
Identities = 64/236 (27%), Positives = 115/236 (48%), Gaps = 8/236 (3%)
Query: 354 ACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGDLL 413
A K++D + + E +L ++ P LV F+ ++ M Y+ G++
Sbjct: 71 AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMF 130
Query: 414 EFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGFAR 473
+ + G E AR + Q+ L +Y+H L++ +RD+K EN+L+ ++++DFGFA
Sbjct: 131 SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFA- 189
Query: 474 MCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFEDKH 533
K + R+ T CG+ Y APEI+ Y K D W+LG+++Y M PF
Sbjct: 190 -----KRVKGRTWTLCGTPEYLAPEIILSKGY-NKAVDWWALGVLIYEMAAGYPPFFADQ 243
Query: 534 IKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQN-RLKIYDIVNSEWIA 588
Q+++ ++ +F S + + D + L+ + L N + + DI N +W A
Sbjct: 244 PIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299
>AY714054-1|AAU04399.1| 306|Homo sapiens aurora-C protein.
Length = 306
Score = 122 bits (295), Expect = 3e-27
Identities = 75/275 (27%), Positives = 138/275 (50%), Gaps = 14/275 (5%)
Query: 14 LLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREID 73
L +++ + +G+G + VYL ++SH +A K++ ++ K+ + L REI+
Sbjct: 35 LTVDDFEIGRPLGKGKFGNVYLARL---KESH-FIVALKVLFKSQIEKEGLEHQLRREIE 90
Query: 74 VLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALG 133
+ L HP+++ +++ F + Y+ + Y G+L + K+ + E + +LA
Sbjct: 91 IQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADA 150
Query: 134 LQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAP 193
L Y H+ ++ HRDIK EN+LL VK++DFG+S V + + + +T CG++ Y P
Sbjct: 151 LTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWS---VHTPS--LRRKTMCGTLDYLPP 205
Query: 194 EILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILS 253
E++ G+ Y K DLW +GV+ + +L PF+ + Y + + RF +
Sbjct: 206 EMIEGRTYDEK-VDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRF----PLSMP 260
Query: 254 LECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSR 288
L + ++ LL P R +L W+ SR
Sbjct: 261 LGARDLISRLLRYQPLERLPLAQILKHPWVQAHSR 295
Score = 114 bits (275), Expect = 8e-25
Identities = 69/241 (28%), Positives = 121/241 (50%), Gaps = 10/241 (4%)
Query: 352 ILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
I+A KV+ S ++ ++ L REIE+ L HP+++ ++ F + ++ + Y RG+
Sbjct: 65 IVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGE 124
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
L + + + + E + +LA A+ Y H+ ++ HRDIK EN+LL VK++DFG+
Sbjct: 125 LYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGW 184
Query: 472 ARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFED 531
+ +R +T CG+L Y PE+++G Y K D+W +G++ Y +L PFE
Sbjct: 185 S-----VHTPSLRRKTMCGTLDYLPPEMIEGRTYDEK-VDLWCIGVLCYELLVGYPPFES 238
Query: 532 KHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDS 591
H + K R+ ++ + LI +L RL + I+ W+ S
Sbjct: 239 AS----HSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHS 294
Query: 592 R 592
R
Sbjct: 295 R 295
>AY661554-1|AAT64422.1| 290|Homo sapiens aurora/Ipl1-related kinase
3 transcript variant 1 protein.
Length = 290
Score = 122 bits (295), Expect = 3e-27
Identities = 75/275 (27%), Positives = 138/275 (50%), Gaps = 14/275 (5%)
Query: 14 LLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREID 73
L +++ + +G+G + VYL ++SH +A K++ ++ K+ + L REI+
Sbjct: 19 LTVDDFEIGRPLGKGKFGNVYLARL---KESH-FIVALKVLFKSQIEKEGLEHQLRREIE 74
Query: 74 VLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALG 133
+ L HP+++ +++ F + Y+ + Y G+L + K+ + E + +LA
Sbjct: 75 IQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADA 134
Query: 134 LQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAP 193
L Y H+ ++ HRDIK EN+LL VK++DFG+S V + + + +T CG++ Y P
Sbjct: 135 LTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWS---VHTPS--LRRKTMCGTLDYLPP 189
Query: 194 EILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILS 253
E++ G+ Y K DLW +GV+ + +L PF+ + Y + + RF +
Sbjct: 190 EMIEGRTYDEK-VDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRF----PLSMP 244
Query: 254 LECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSR 288
L + ++ LL P R +L W+ SR
Sbjct: 245 LGARDLISRLLRYQPLERLPLAQILKHPWVQAHSR 279
Score = 114 bits (275), Expect = 8e-25
Identities = 69/241 (28%), Positives = 121/241 (50%), Gaps = 10/241 (4%)
Query: 352 ILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
I+A KV+ S ++ ++ L REIE+ L HP+++ ++ F + ++ + Y RG+
Sbjct: 49 IVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGE 108
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
L + + + + E + +LA A+ Y H+ ++ HRDIK EN+LL VK++DFG+
Sbjct: 109 LYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGW 168
Query: 472 ARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFED 531
+ +R +T CG+L Y PE+++G Y K D+W +G++ Y +L PFE
Sbjct: 169 S-----VHTPSLRRKTMCGTLDYLPPEMIEGRTYDEK-VDLWCIGVLCYELLVGYPPFES 222
Query: 532 KHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDS 591
H + K R+ ++ + LI +L RL + I+ W+ S
Sbjct: 223 AS----HSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHS 278
Query: 592 R 592
R
Sbjct: 279 R 279
>AB017332-1|BAA76292.1| 309|Homo sapiens Aurora/Ipl1-related kinase
3 protein.
Length = 309
Score = 122 bits (295), Expect = 3e-27
Identities = 75/275 (27%), Positives = 138/275 (50%), Gaps = 14/275 (5%)
Query: 14 LLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKFLPREID 73
L +++ + +G+G + VYL ++SH +A K++ ++ K+ + L REI+
Sbjct: 38 LTVDDFEIGRPLGKGKFGNVYLARL---KESH-FIVALKVLFKSQIEKEGLEHQLRREIE 93
Query: 74 VLVRLNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVWTRQLALG 133
+ L HP+++ +++ F + Y+ + Y G+L + K+ + E + +LA
Sbjct: 94 IQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADA 153
Query: 134 LQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCGSMSYAAP 193
L Y H+ ++ HRDIK EN+LL VK++DFG+S V + + + +T CG++ Y P
Sbjct: 154 LTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWS---VHTPS--LRRKTMCGTLDYLPP 208
Query: 194 EILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYEQQMGKKYRFRSRVASILS 253
E++ G+ Y K DLW +GV+ + +L PF+ + Y + + RF +
Sbjct: 209 EMIEGRTYDEK-VDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRF----PLSMP 263
Query: 254 LECKTVVKHLLEPDPGLRHSATNVLDSEWIAMDSR 288
L + ++ LL P R +L W+ SR
Sbjct: 264 LGARDLISRLLRYQPLERLPLAQILKHPWVQAHSR 298
Score = 114 bits (275), Expect = 8e-25
Identities = 69/241 (28%), Positives = 121/241 (50%), Gaps = 10/241 (4%)
Query: 352 ILACKVIDTSTAPRDFVKKFLPREIEMLIKLSHPHLVHTHSIFQRRYKYFIFMRYMERGD 411
I+A KV+ S ++ ++ L REIE+ L HP+++ ++ F + ++ + Y RG+
Sbjct: 68 IVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGE 127
Query: 412 LLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQNVKLSDFGF 471
L + + + + E + +LA A+ Y H+ ++ HRDIK EN+LL VK++DFG+
Sbjct: 128 LYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGW 187
Query: 472 ARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVMLNRAMPFED 531
+ +R +T CG+L Y PE+++G Y K D+W +G++ Y +L PFE
Sbjct: 188 S-----VHTPSLRRKTMCGTLDYLPPEMIEGRTYDEK-VDLWCIGVLCYELLVGYPPFES 241
Query: 532 KHIKQLHQAQINKNWKFRSRYIDTISDNCKRLIGLMLEPNHQNRLKIYDIVNSEWIAMDS 591
H + K R+ ++ + LI +L RL + I+ W+ S
Sbjct: 242 AS----HSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHS 297
Query: 592 R 592
R
Sbjct: 298 R 298
>Z98752-7|CAC18509.1| 367|Homo sapiens serum/glucocorticoid
regulated kinase 2 protein.
Length = 367
Score = 122 bits (294), Expect = 4e-27
Identities = 73/229 (31%), Positives = 116/229 (50%), Gaps = 9/229 (3%)
Query: 8 PSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKF 67
PS + K +G+G Y KV L +K S + A K+++ K
Sbjct: 24 PSANPNAQPTDFDFLKVIGKGNYGKVLL----AKRKSDGAFYAVKVLQKKSILKKKEQSH 79
Query: 68 LPREIDVLVR-LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVW 126
+ E VL++ + HP L+ + FQ K Y + Y G+L ++ + E +AR +
Sbjct: 80 IMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFY 139
Query: 127 TRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCG 186
++A + YLH L I +RD+K EN+LL +V L+DFG + VE ++ + T+CG
Sbjct: 140 AAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPED---TTSTFCG 196
Query: 187 SMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYE 235
+ Y APE+LR +PY + D W LG VL+ ML+ PF + ++YE
Sbjct: 197 TPEYLAPEVLRKEPY-DRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYE 244
Score = 109 bits (261), Expect = 4e-23
Identities = 63/197 (31%), Positives = 103/197 (52%), Gaps = 5/197 (2%)
Query: 344 ASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIK-LSHPHLVHTHSIFQRRYKYFI 402
A + + A KV+ + + + + E +L+K + HP LV FQ K +
Sbjct: 52 AKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYF 111
Query: 403 FMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQ 462
+ Y+ G+L + + E +AR + ++A AI Y+H L I +RD+K EN+LL
Sbjct: 112 VLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQG 171
Query: 463 NVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVM 522
+V L+DFG +C + E + TFCG+ Y APE+L+ PY + D W LG V+Y M
Sbjct: 172 HVVLTDFG---LCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPY-DRAVDWWCLGAVLYEM 227
Query: 523 LNRAMPFEDKHIKQLHQ 539
L+ PF + + Q+++
Sbjct: 228 LHGLPPFYSQDVSQMYE 244
>Z98752-5|CAI42312.1| 427|Homo sapiens serum/glucocorticoid
regulated kinase 2 protein.
Length = 427
Score = 122 bits (294), Expect = 4e-27
Identities = 73/229 (31%), Positives = 116/229 (50%), Gaps = 9/229 (3%)
Query: 8 PSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKF 67
PS + K +G+G Y KV L +K S + A K+++ K
Sbjct: 84 PSANPNAQPTDFDFLKVIGKGNYGKVLL----AKRKSDGAFYAVKVLQKKSILKKKEQSH 139
Query: 68 LPREIDVLVR-LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVW 126
+ E VL++ + HP L+ + FQ K Y + Y G+L ++ + E +AR +
Sbjct: 140 IMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFY 199
Query: 127 TRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCG 186
++A + YLH L I +RD+K EN+LL +V L+DFG + VE ++ + T+CG
Sbjct: 200 AAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPED---TTSTFCG 256
Query: 187 SMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYE 235
+ Y APE+LR +PY + D W LG VL+ ML+ PF + ++YE
Sbjct: 257 TPEYLAPEVLRKEPY-DRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYE 304
Score = 109 bits (261), Expect = 4e-23
Identities = 63/197 (31%), Positives = 103/197 (52%), Gaps = 5/197 (2%)
Query: 344 ASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIK-LSHPHLVHTHSIFQRRYKYFI 402
A + + A KV+ + + + + E +L+K + HP LV FQ K +
Sbjct: 112 AKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYF 171
Query: 403 FMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQ 462
+ Y+ G+L + + E +AR + ++A AI Y+H L I +RD+K EN+LL
Sbjct: 172 VLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQG 231
Query: 463 NVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVM 522
+V L+DFG +C + E + TFCG+ Y APE+L+ PY + D W LG V+Y M
Sbjct: 232 HVVLTDFG---LCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPY-DRAVDWWCLGAVLYEM 287
Query: 523 LNRAMPFEDKHIKQLHQ 539
L+ PF + + Q+++
Sbjct: 288 LHGLPPFYSQDVSQMYE 304
>BC065511-1|AAH65511.1| 367|Homo sapiens SGK2 protein protein.
Length = 367
Score = 122 bits (294), Expect = 4e-27
Identities = 73/229 (31%), Positives = 116/229 (50%), Gaps = 9/229 (3%)
Query: 8 PSEENTLLTKGYKLTKFVGEGAYAKVYLTEYSSKEDSHKSTLACKIIETAKAPKDFVVKF 67
PS + K +G+G Y KV L +K S + A K+++ K
Sbjct: 24 PSANPNAQPTDFDFLKVIGKGNYGKVLL----AKRKSDGAFYAVKVLQKKSILKKKEQSH 79
Query: 68 LPREIDVLVR-LNHPHLIHVHSIFQRKTKYYIFMRYTENGDLLSYILKNGCVSENQARVW 126
+ E VL++ + HP L+ + FQ K Y + Y G+L ++ + E +AR +
Sbjct: 80 IMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFY 139
Query: 127 TRQLALGLQYLHELEIAHRDIKCENVLLTANFNVKLSDFGFSRFCVESDNQPVLSETYCG 186
++A + YLH L I +RD+K EN+LL +V L+DFG + VE ++ + T+CG
Sbjct: 140 AAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPED---TTSTFCG 196
Query: 187 SMSYAAPEILRGKPYCPKPTDLWSLGVVLFVMLNKSMPFDDTRMRKLYE 235
+ Y APE+LR +PY + D W LG VL+ ML+ PF + ++YE
Sbjct: 197 TPEYLAPEVLRKEPY-DRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYE 244
Score = 109 bits (261), Expect = 4e-23
Identities = 63/197 (31%), Positives = 103/197 (52%), Gaps = 5/197 (2%)
Query: 344 ASKNDKLSILACKVIDTSTAPRDFVKKFLPREIEMLIK-LSHPHLVHTHSIFQRRYKYFI 402
A + + A KV+ + + + + E +L+K + HP LV FQ K +
Sbjct: 52 AKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYF 111
Query: 403 FMRYMERGDLLEFVLQRGAVQEDQARIWTRQLALAIQYMHELEIAHRDIKCENVLLTANQ 462
+ Y+ G+L + + E +AR + ++A AI Y+H L I +RD+K EN+LL
Sbjct: 112 VLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQG 171
Query: 463 NVKLSDFGFARMCVDKKLNEIRSETFCGSLSYTAPEILQGTPYLPKPTDVWSLGIVVYVM 522
+V L+DFG +C + E + TFCG+ Y APE+L+ PY + D W LG V+Y M
Sbjct: 172 HVVLTDFG---LCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPY-DRAVDWWCLGAVLYEM 227
Query: 523 LNRAMPFEDKHIKQLHQ 539
L+ PF + + Q+++
Sbjct: 228 LHGLPPFYSQDVSQMYE 244
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.320 0.135 0.400
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 95,576,231
Number of Sequences: 224733
Number of extensions: 3919962
Number of successful extensions: 23939
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 2319
Number of HSP's successfully gapped in prelim test: 475
Number of HSP's that attempted gapping in prelim test: 11019
Number of HSP's gapped (non-prelim): 6437
length of query: 655
length of database: 73,234,838
effective HSP length: 95
effective length of query: 560
effective length of database: 51,885,203
effective search space: 29055713680
effective search space used: 29055713680
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.8 bits)
S2: 68 (31.5 bits)
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