Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001004-TA|BGIBMGA001004-PA|IPR001128|Cytochrome P450,
IPR000923|Blue (type 1) copper domain, IPR002401|E-class P450, group I
(507 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
BC060857-1|AAH60857.1| 525|Homo sapiens cytochrome P450, family... 214 7e-55
AY422002-1|AAR31180.1| 525|Homo sapiens cytochrome P450 4V2 pro... 214 7e-55
AK126473-1|BAC86562.1| 503|Homo sapiens protein ( Homo sapiens ... 214 7e-55
AK122600-1|BAC85487.1| 525|Homo sapiens protein ( Homo sapiens ... 214 7e-55
AF133298-1|AAD49566.1| 520|Homo sapiens cytochrome P450 protein. 165 3e-40
D26480-1|BAA05490.1| 520|Homo sapiens leukotriene B4 omega-hydr... 163 2e-39
BC067440-1|AAH67440.1| 520|Homo sapiens cytochrome P450, family... 163 2e-39
BC067439-1|AAH67439.1| 520|Homo sapiens cytochrome P450, family... 163 2e-39
BC067437-1|AAH67437.1| 520|Homo sapiens cytochrome P450, family... 163 2e-39
AF467894-1|AAL67578.1| 520|Homo sapiens cytochrome P450, subfam... 163 2e-39
AC005336-1|AAC27730.1| 520|Homo sapiens CYP4F2 protein. 163 2e-39
AB015306-1|BAA75823.1| 520|Homo sapiens Leukotriene B4 omega-hy... 163 2e-39
BC035350-1|AAH35350.1| 524|Homo sapiens cytochrome P450, family... 159 2e-38
AY792513-1|AAV40834.1| 520|Homo sapiens cytochrome P450, family... 159 2e-38
AY358977-1|AAQ89336.1| 524|Homo sapiens CYP4F12 protein. 159 2e-38
AY008841-1|AAG33247.1| 524|Homo sapiens cytochrome P450 isoform... 159 2e-38
AF054821-1|AAC08589.1| 520|Homo sapiens cytochrome P-450 protein. 159 2e-38
AC004523-1|AAC11543.1| 458|Homo sapiens F22329_1 protein. 159 2e-38
AB035131-1|BAB18270.1| 524|Homo sapiens cytochrome P450 protein. 159 2e-38
AB035130-1|BAB18269.1| 524|Homo sapiens cytochrome P450 protein. 159 2e-38
D12620-1|BAA02144.1| 520|Homo sapiens cytochrome P-450LTBV prot... 158 4e-38
AB002461-1|BAA25991.1| 520|Homo sapiens leukotriene B4 omega-hy... 158 4e-38
AB002454-1|BAA25990.1| 520|Homo sapiens leukotriene B4 omega-hy... 158 4e-38
U02388-1|AAC50052.2| 520|Homo sapiens cytochrome P450 4F2 protein. 158 5e-38
X16699-1|CAA34672.1| 511|Homo sapiens protein ( Human mRNA for ... 155 3e-37
J02871-1|AAA35712.1| 511|Homo sapiens protein ( Human lung cyto... 155 3e-37
DQ518907-1|ABF47106.1| 511|Homo sapiens cytochrome P450, family... 155 3e-37
BC017758-1|AAH17758.1| 512|Homo sapiens cytochrome P450, family... 155 3e-37
AY151049-1|AAN72312.1| 497|Homo sapiens pulmonary cytochrome P4... 155 3e-37
AY151048-1|AAN72311.1| 512|Homo sapiens pulmonary cytochrome P4... 155 3e-37
AY064485-1|AAL57720.1| 511|Homo sapiens cytochrome P450 protein. 155 3e-37
AL593856-7|CAI16983.1| 497|Homo sapiens cytochrome P450, family... 155 3e-37
AL593856-6|CAI16982.1| 512|Homo sapiens cytochrome P450, family... 155 3e-37
AL593856-5|CAI16981.1| 511|Homo sapiens cytochrome P450, family... 155 3e-37
AL356793-4|CAI22559.1| 511|Homo sapiens cytochrome P450, family... 155 3e-37
AL356793-3|CAI22557.1| 512|Homo sapiens cytochrome P450, family... 155 3e-37
AL356793-2|CAI22558.1| 497|Homo sapiens cytochrome P450, family... 155 3e-37
AF491285-1|AAM09532.1| 511|Homo sapiens cytochrome P450 protein. 155 3e-37
AY064486-1|AAL57721.1| 511|Homo sapiens cytochrome P450 protein. 155 5e-37
BC016853-1|AAH16853.1| 524|Homo sapiens CYP4F11 protein protein. 151 6e-36
AF236085-1|AAG15889.1| 524|Homo sapiens CYP4F11 protein. 150 1e-35
S67580-1|AAB29502.1| 519|Homo sapiens fatty acid omega-hydroxyl... 148 5e-35
AY280371-1|AAQ21367.1| 519|Homo sapiens cytochrome P450 4A22K p... 148 5e-35
S67581-1|AAB29503.1| 591|Homo sapiens fatty acid omega-hydroxyl... 147 7e-35
AY358631-1|AAQ88994.1| 505|Homo sapiens EPSW3060 protein. 147 7e-35
AY280372-1|AAQ21368.1| 519|Homo sapiens cytochrome P450 4A22 pr... 147 7e-35
AY262056-1|AAO89257.1| 505|Homo sapiens cytochrome P450 protein. 147 7e-35
AL450996-2|CAH71036.1| 505|Homo sapiens cytochrome P450, family... 147 7e-35
AL135960-6|CAI19734.1| 505|Homo sapiens cytochrome P450, family... 147 7e-35
L04751-1|AAA58436.1| 519|Homo sapiens cytochrome P450 protein. 146 1e-34
D26481-1|BAA05491.1| 519|Homo sapiens fatty acids omega-hydroxy... 146 1e-34
AY369778-1|AAQ56847.1| 519|Homo sapiens cytochrome P450, family... 146 1e-34
AL731892-3|CAH72778.1| 519|Homo sapiens cytochrome P450, family... 146 1e-34
D13705-1|BAA02864.1| 521|Homo sapiens fatty acid omega-hydroxyl... 146 2e-34
AF525488-1|AAO16078.1| 519|Homo sapiens cytochrome P450, subfam... 145 4e-34
BC028102-1|AAH28102.1| 509|Homo sapiens cytochrome P450, family... 144 5e-34
AY358537-1|AAQ88901.1| 509|Homo sapiens EFSW1929 protein. 144 5e-34
AM040940-1|CAJ13826.1| 509|Homo sapiens cytochrome P450 protein. 144 5e-34
AL450996-1|CAH71035.1| 509|Homo sapiens cytochrome P450, family... 144 5e-34
AK131355-1|BAD18508.1| 508|Homo sapiens protein ( Homo sapiens ... 144 5e-34
AK098065-1|BAC05226.1| 509|Homo sapiens protein ( Homo sapiens ... 144 5e-34
AK091806-1|BAC03751.1| 444|Homo sapiens protein ( Homo sapiens ... 144 5e-34
BC093896-1|AAH93896.1| 531|Homo sapiens cytochrome P450, family... 144 6e-34
BC093894-1|AAH93894.1| 531|Homo sapiens cytochrome P450, family... 144 6e-34
BC069351-1|AAH69351.1| 531|Homo sapiens cytochrome P450, family... 144 6e-34
AK096820-1|BAC04868.1| 531|Homo sapiens protein ( Homo sapiens ... 144 6e-34
AL135960-10|CAI19737.1| 519|Homo sapiens cytochrome P450, famil... 143 1e-33
AF208532-1|AAF76722.1| 519|Homo sapiens fatty acid omega-hydrox... 142 2e-33
BC041158-1|AAH41158.1| 455|Homo sapiens CYP4A11 protein protein. 134 5e-31
AL731892-4|CAH72779.1| 455|Homo sapiens cytochrome P450, family... 134 5e-31
M14096-1|AAA35744.1| 503|Homo sapiens protein ( Human cytochrom... 132 4e-30
M13785-1|AAA35742.1| 504|Homo sapiens protein ( Human liver glu... 132 4e-30
J04449-1|AAA35747.1| 502|Homo sapiens cytochrome P450 nifedipin... 132 4e-30
D00003-1|BAA00001.1| 504|Homo sapiens cytochrome P-450 protein. 132 4e-30
M18907-1|AAA35745.1| 503|Homo sapiens protein ( Human P450 mRNA... 131 5e-30
DQ924960-1|ABI96208.1| 503|Homo sapiens cytochrome P450 family ... 131 5e-30
DQ005611-1|AAY16980.1| 503|Homo sapiens cytochrome P450, family... 131 5e-30
BC101631-1|AAI01632.1| 503|Homo sapiens cytochrome P450, subfam... 131 5e-30
BC069418-1|AAH69418.1| 503|Homo sapiens cytochrome P450, family... 131 5e-30
AJ563377-1|CAD91345.1| 353|Homo sapiens cytochrome P450 protein. 131 5e-30
AJ563376-2|CAD91645.1| 430|Homo sapiens cytochrome P450 protein. 131 5e-30
AJ563375-1|CAD91343.1| 503|Homo sapiens cytochrome P450 protein. 131 5e-30
AF280107-2|AAG32290.1| 503|Homo sapiens cytochrome P450 polypep... 131 5e-30
AF209389-1|AAF21034.1| 503|Homo sapiens cytochrome P450 IIIA4 p... 131 5e-30
AL135960-11|CAI19738.1| 455|Homo sapiens cytochrome P450, famil... 131 6e-30
X12387-1|CAA30944.1| 503|Homo sapiens protein ( Human mRNA for ... 130 9e-30
D00408-1|BAA00310.1| 503|Homo sapiens cytochrome P-450 HFLa pro... 130 1e-29
BC067436-1|AAH67436.1| 503|Homo sapiens cytochrome P450, family... 130 1e-29
AF315325-1|AAG48618.1| 535|Homo sapiens cytochrome P450 variant... 130 1e-29
AF280107-3|AAG32289.1| 503|Homo sapiens cytochrome P450 polypep... 130 1e-29
AF182273-1|AAF13598.1| 503|Homo sapiens cytochrome P450-3A4 pro... 129 2e-29
AY390424-1|AAQ92352.1| 503|Homo sapiens cytochrome P450 CYP3A43... 128 3e-29
BC100981-1|AAI00982.1| 393|Homo sapiens CYP3A43 protein protein. 128 6e-29
AY390425-1|AAQ92353.1| 503|Homo sapiens cytochrome P450 CYP3A43... 128 6e-29
AF337813-1|AAK38841.1| 503|Homo sapiens cytochrome P450 subfami... 128 6e-29
AF319634-1|AAK00325.1| 503|Homo sapiens cytochrome P450 CYP3A43... 128 6e-29
AF280108-1|AAG33009.1| 503|Homo sapiens cytochrome P450 subfami... 128 6e-29
AC011904-4|AAS07395.1| 503|Homo sapiens unknown protein. 128 6e-29
J04813-1|AAA02993.1| 502|Homo sapiens cytochrome P450 PCN3 prot... 124 7e-28
BC033862-1|AAH33862.1| 502|Homo sapiens cytochrome P450, family... 124 7e-28
AC005020-1|AAS02016.1| 502|Homo sapiens unknown protein. 124 7e-28
AF280109-1|AAG33010.1| 504|Homo sapiens cytochrome P450 subfami... 124 1e-27
AC011904-5|AAS07394.1| 504|Homo sapiens unknown protein. 124 1e-27
AK223008-1|BAD96728.1| 502|Homo sapiens cytochrome P450, family... 123 1e-27
X71480-1|CAA50586.1| 141|Homo sapiens cytochrome P450 protein. 119 3e-26
D12621-1|BAA02145.1| 389|Homo sapiens cytochrome P-450LTBV prot... 106 2e-22
BC022539-1|AAH22539.1| 500|Homo sapiens cytochrome P450, family... 101 6e-21
AF094480-1|AAD41244.1| 500|Homo sapiens cholesterol 24-hydroxyl... 101 6e-21
AL358613-3|CAH72804.1| 428|Homo sapiens cytochrome P450, family... 96 3e-19
AL358613-2|CAH72803.1| 497|Homo sapiens cytochrome P450, family... 96 3e-19
AF005418-1|AAB88881.1| 497|Homo sapiens retinoic acid hydroxyla... 96 3e-19
AY064484-1|AAL57719.1| 295|Homo sapiens truncated cytochrome P4... 95 5e-19
U37143-1|AAC50370.2| 502|Homo sapiens cytochrome P450 monooxyge... 95 7e-19
BC032594-1|AAH32594.1| 502|Homo sapiens cytochrome P450, family... 95 7e-19
AY426985-1|AAQ93356.1| 502|Homo sapiens cytochrome P450, family... 95 7e-19
AF272142-1|AAM44456.1| 502|Homo sapiens cytochrome P450 protein. 95 7e-19
M80647-1|AAA60618.1| 534|Homo sapiens thromboxane synthase prot... 94 9e-19
BC132767-1|AAI32768.1| 544|Homo sapiens cytochrome P450, family... 94 9e-19
BC104909-1|AAI04910.1| 501|Homo sapiens cytochrome P450, family... 94 9e-19
BC104907-1|AAI04908.1| 501|Homo sapiens cytochrome P450, family... 94 9e-19
BC041157-1|AAH41157.1| 534|Homo sapiens thromboxane A synthase ... 94 9e-19
BC014117-1|AAH14117.1| 466|Homo sapiens TBXAS1 protein protein. 94 9e-19
AY343323-1|AAQ21380.1| 544|Homo sapiens cytochrome P450 protein. 94 9e-19
AY323817-1|AAQ23114.1| 501|Homo sapiens cytochrome P450 2R1 pro... 94 9e-19
AK223466-1|BAD97186.1| 534|Homo sapiens thromboxane A synthase ... 94 9e-19
AF233625-1|AAF99279.1| 534|Homo sapiens thromboxane synthase pr... 94 9e-19
AF233620-1|AAF99274.1| 534|Homo sapiens thromboxane synthase pr... 94 9e-19
AF233619-1|AAF99273.1| 534|Homo sapiens thromboxane synthase pr... 94 9e-19
AF233618-1|AAF99272.1| 534|Homo sapiens thromboxane synthase pr... 94 9e-19
AF233617-1|AAF99271.1| 534|Homo sapiens thromboxane synthase pr... 94 9e-19
AF233616-1|AAF99270.1| 534|Homo sapiens thromboxane synthase pr... 94 9e-19
AF233615-1|AAF99269.1| 534|Homo sapiens thromboxane synthase pr... 94 9e-19
AB080265-1|BAB85489.1| 502|Homo sapiens cytochrome P450 2J2 pro... 94 9e-19
AF233622-1|AAF99276.1| 534|Homo sapiens thromboxane synthase pr... 94 1e-18
D34625-1|BAA07011.1| 533|Homo sapiens thromboxane synthase prot... 93 2e-18
AF233624-1|AAF99278.1| 534|Homo sapiens thromboxane synthase pr... 93 2e-18
AF233621-1|AAF99275.1| 534|Homo sapiens thromboxane synthase pr... 93 2e-18
AF280110-1|AAG33011.1| 420|Homo sapiens cytochrome P450 subfami... 93 3e-18
AF233623-1|AAF99277.1| 534|Homo sapiens thromboxane synthase pr... 93 3e-18
M63871-1|AAA59984.1| 508|Homo sapiens CYP17 protein. 92 4e-18
M31153-1|AAA52140.1| 508|Homo sapiens CYP17 protein. 92 4e-18
M19489-1|AAA36405.1| 508|Homo sapiens CYP17 protein. 92 4e-18
M14564-1|AAA52151.1| 508|Homo sapiens CYP17 protein. 92 4e-18
DQ530598-1|ABF50972.1| 508|Homo sapiens cytochrome P450, family... 92 4e-18
BT020000-1|AAV38803.1| 508|Homo sapiens cytochrome P450, family... 92 4e-18
BC067431-1|AAH67431.1| 491|Homo sapiens cytochrome P450, family... 92 4e-18
BC063388-1|AAH63388.1| 508|Homo sapiens cytochrome P450, family... 92 4e-18
BC062997-1|AAH62997.1| 508|Homo sapiens cytochrome P450, family... 92 4e-18
AL358790-3|CAI52498.1| 508|Homo sapiens cytochrome P450, family... 92 4e-18
AK097373-1|BAC05026.1| 340|Homo sapiens protein ( Homo sapiens ... 92 5e-18
M61854-1|AAB59426.1| 490|Homo sapiens cytochrome protein. 91 6e-18
AF182277-1|AAF13602.1| 491|Homo sapiens cytochrome P450-2B6 pro... 91 6e-18
X13930-1|CAA32118.1| 494|Homo sapiens protein ( Human CYP2A4 mR... 91 8e-18
X13929-1|CAA32117.1| 448|Homo sapiens P-450 IIA3 protein (1 is ... 91 8e-18
M33318-1|AAA52067.1| 494|Homo sapiens CYP2A protein. 91 8e-18
L07093-1|AAA36660.1| 468|Homo sapiens cytochrome P450 protein. 91 8e-18
BC100982-1|AAI00983.1| 280|Homo sapiens CYP3A43 protein protein. 91 8e-18
BC096256-1|AAH96256.1| 494|Homo sapiens cytochrome P450, family... 91 8e-18
BC096255-1|AAH96255.1| 494|Homo sapiens cytochrome P450, family... 91 8e-18
BC096254-1|AAH96254.1| 494|Homo sapiens cytochrome P450, family... 91 8e-18
BC096253-1|AAH96253.3| 494|Homo sapiens cytochrome P450, family... 91 8e-18
BC067430-1|AAH67430.1| 491|Homo sapiens cytochrome P450, family... 91 8e-18
AY796203-1|AAV41877.1| 490|Homo sapiens cytochrome P450, family... 91 8e-18
AL583836-2|CAH74068.1| 490|Homo sapiens cytochrome P450, family... 91 8e-18
AL133513-2|CAH73444.1| 490|Homo sapiens cytochrome P450, family... 91 8e-18
AF182275-1|AAF13600.1| 494|Homo sapiens cytochrome P450-2A6 pro... 91 8e-18
X13897-1|CAA32097.1| 489|Homo sapiens protein ( Human mRNA for ... 91 1e-17
M61858-1|AAA52145.1| 370|Homo sapiens CYP2C17 protein. 91 1e-17
M21939-1|AAA52158.1| 485|Homo sapiens CYP2C protein. 91 1e-17
M15331-1|AAA52157.1| 485|Homo sapiens CYP2C protein. 91 1e-17
AJ563378-3|CAD91347.1| 173|Homo sapiens hypothetical protein pr... 91 1e-17
AJ563378-2|CAD91647.1| 160|Homo sapiens cytochrome P450 protein. 91 1e-17
S46963-1|AAB23864.2| 477|Homo sapiens cytochrome P-450 protein. 90 1e-17
M21940-1|AAA52159.1| 383|Homo sapiens CYP2C protein. 90 1e-17
D00173-1|BAA00123.1| 487|Homo sapiens cytochrome P-450 protein. 90 1e-17
BC125054-1|AAI25055.1| 490|Homo sapiens cytochrome P450, family... 90 1e-17
BC117165-1|AAI17166.1| 494|Homo sapiens cytochrome P450, family... 90 1e-17
AY702706-1|AAT94065.1| 490|Homo sapiens cytochrome P450, family... 90 1e-17
AY341248-1|AAP88931.1| 490|Homo sapiens cytochrome P450, family... 90 1e-17
AL359672-1|CAH71303.1| 490|Homo sapiens cytochrome P450, family... 90 1e-17
M33317-1|AAA52138.1| 494|Homo sapiens CYP2A protein. 90 2e-17
BC033691-1|AAH33691.1| 504|Homo sapiens cytochrome P450, family... 89 3e-17
AY358603-1|AAQ88966.1| 504|Homo sapiens Cytochrome p450 protein. 89 3e-17
AF335278-1|AAK13498.1| 504|Homo sapiens cytochrome P450 2S1 pro... 89 3e-17
M29874-1|AAA52144.1| 491|Homo sapiens CYP2B protein. 89 3e-17
DQ298753-1|ABB84469.1| 491|Homo sapiens cytochrome P450, family... 89 3e-17
AY696295-1|AAU10524.1| 292|Homo sapiens cytochrome P450 protein. 89 3e-17
AY513608-1|AAR90939.1| 494|Homo sapiens cytochrome P450 2A13 va... 89 3e-17
AY513606-1|AAR90937.1| 494|Homo sapiens cytochrome P450 2A13 va... 89 3e-17
AY513605-1|AAR90936.1| 494|Homo sapiens cytochrome P450 2A13 va... 89 3e-17
AY513604-1|AAR90935.1| 494|Homo sapiens cytochrome P450 2A13 va... 89 3e-17
AF209774-1|AAG35775.1| 494|Homo sapiens cytochrome P450 2A13 pr... 89 3e-17
AC023172-1|AAF32444.1| 491|Homo sapiens CYP2B6 protein. 89 3e-17
AY513609-1|AAR90940.1| 494|Homo sapiens cytochrome P450 2A13 va... 88 8e-17
AK090886-1|BAC03539.1| 337|Homo sapiens protein ( Homo sapiens ... 88 8e-17
M61856-1|AAB59356.1| 490|Homo sapiens cytochrome protein. 87 1e-16
BC096258-1|AAH96258.1| 490|Homo sapiens cytochrome P450, family... 87 1e-16
BC096257-1|AAH96257.1| 490|Homo sapiens cytochrome P450, family... 87 1e-16
BC069666-1|AAH69666.1| 490|Homo sapiens cytochrome P450, family... 87 1e-16
AL583836-1|CAH74067.1| 490|Homo sapiens cytochrome P450, family... 87 1e-16
X65962-1|CAA46778.1| 356|Homo sapiens cytochrome P-450 II C pro... 87 2e-16
AK223510-1|BAD97230.1| 490|Homo sapiens cytochrome P450, family... 87 2e-16
AK027605-1|BAB55227.1| 564|Homo sapiens protein ( Homo sapiens ... 86 3e-16
BC032322-1|AAH32322.1| 509|Homo sapiens cytochrome P450, family... 85 4e-16
AL135960-9|CAI19736.1| 421|Homo sapiens cytochrome P450, family... 85 4e-16
U51692-1|AAC50951.1| 503|Homo sapiens lanosterol 14-alpha demet... 85 6e-16
U23942-1|AAB39951.1| 509|Homo sapiens lanosterol 14-demethylase... 85 6e-16
U22028-1|AAB40519.1| 494|Homo sapiens cytochrome P450 protein. 85 6e-16
D55653-1|BAA09512.1| 509|Homo sapiens lanosterol 14-demethylase... 85 6e-16
AC000120-2|AAB46356.1| 509|Homo sapiens unknown protein. 85 6e-16
U22029-1|AAB40520.1| 494|Homo sapiens cytochrome P450 protein. 85 7e-16
L16876-1|AAA02630.1| 490|Homo sapiens cytochrome P-4502C18 prot... 85 7e-16
L13286-1|AAA62379.1| 513|Homo sapiens 1,25-dihydroxyvitamin D3 ... 85 7e-16
Y00498-1|CAA68550.1| 490|Homo sapiens IIC2 protein. 83 3e-15
U22027-1|AAB40518.1| 494|Homo sapiens cytochrome P450 protein. 83 3e-15
M17397-1|AAA35739.1| 490|Homo sapiens protein ( Human cytochrom... 83 3e-15
BC020596-1|AAH20596.1| 490|Homo sapiens cytochrome P450, family... 83 3e-15
AY514490-1|AAR89907.1| 490|Homo sapiens cytochrome P450, family... 83 3e-15
AL359672-5|CAH71307.1| 490|Homo sapiens cytochrome P450, family... 83 3e-15
S67623-1|AAB29308.1| 257|Homo sapiens 25-hydroxyvitamin D 24-hy... 82 4e-15
AY858838-1|AAW50795.1| 372|Homo sapiens vitamin D 24-hydroxylas... 82 4e-15
AL138805-3|CAB91829.1| 514|Homo sapiens cytochrome P450, family... 82 4e-15
AL138805-1|CAM27342.1| 372|Homo sapiens cytochrome P450, family... 82 4e-15
BX538127-1|CAD98029.1| 310|Homo sapiens hypothetical protein pr... 82 5e-15
BC096260-1|AAH96260.1| 431|Homo sapiens CYP2C18 protein protein. 82 5e-15
BC022851-1|AAH22851.1| 215|Homo sapiens CYP4A11 protein protein. 82 5e-15
M21942-1|AAA52161.1| 462|Homo sapiens CYP2C protein. 81 7e-15
L39102-1|AAL31348.1| 217|Homo sapiens S-mephenytoin 4-hydroxyla... 81 7e-15
M21941-1|AAA52160.1| 480|Homo sapiens CYP2C protein. 81 9e-15
AK131190-1|BAD18388.1| 372|Homo sapiens .-.-). protein. 81 9e-15
BC109205-1|AAI09206.1| 512|Homo sapiens cytochrome P450, family... 80 2e-14
BC069443-1|AAH69443.1| 512|Homo sapiens cytochrome P450, family... 80 2e-14
BC039307-1|AAH39307.1| 372|Homo sapiens FLJ16008 protein protein. 80 2e-14
AF252297-1|AAF76003.1| 512|Homo sapiens cytochrome P450 retinoi... 80 2e-14
AC007002-1|AAY14690.1| 512|Homo sapiens unknown protein. 80 2e-14
AF221943-1|AAF86378.1| 175|Homo sapiens leukotriene B4 omega hy... 80 2e-14
M33388-1|AAA53500.1| 497|Homo sapiens cytochrome P450 IID6 prot... 79 3e-14
M33189-1|AAA35737.1| 500|Homo sapiens protein ( Human debrisoqu... 79 3e-14
M24499-1|AAA36403.1| 373|Homo sapiens cytochrome P450db1 protein. 79 3e-14
DQ282154-1|ABB77902.1| 497|Homo sapiens cytochrome P450 2D6 pro... 79 3e-14
DQ282152-1|ABB77900.1| 497|Homo sapiens cytochrome P450 2D6 pro... 79 3e-14
DQ282146-1|ABB77897.1| 497|Homo sapiens cytochrome P450 2D6 pro... 79 3e-14
DQ282145-1|ABB77896.1| 497|Homo sapiens cytochrome P450 2D6 pro... 79 3e-14
DQ282144-1|ABB77895.1| 497|Homo sapiens cytochrome P450 2D6 pro... 79 3e-14
DQ211354-2|ABB01372.1| 497|Homo sapiens cytochrome P450 2D6 pro... 79 3e-14
DQ211353-2|ABB01371.1| 497|Homo sapiens cytochrome P450 2D6 pro... 79 3e-14
DQ211353-1|ABB01370.1| 497|Homo sapiens cytochrome P450 2D6 pro... 79 3e-14
BC075024-1|AAH75024.1| 497|Homo sapiens cytochrome P450, family... 79 3e-14
BC075023-1|AAH75023.1| 497|Homo sapiens cytochrome P450, family... 79 3e-14
AY545216-1|AAS55001.1| 497|Homo sapiens cytochrome P4502D6 prot... 79 3e-14
AB209492-1|BAD92729.1| 566|Homo sapiens Debrisoquine 4-hydroxyl... 79 3e-14
X59812-1|CAA42481.1| 530|Homo sapiens Vitamin D3 25-hydroxylase... 79 5e-14
X08006-1|CAA30807.1| 497|Homo sapiens cytochrome P450 db1 protein. 79 5e-14
M62401-1|AAA52142.1| 531|Homo sapiens sterol 27-hydroxylase pro... 79 5e-14
M20403-1|AAA52153.1| 497|Homo sapiens CYP2D protein. 79 5e-14
BC051851-1|AAH51851.1| 531|Homo sapiens cytochrome P450, family... 79 5e-14
BC040430-1|AAH40430.1| 531|Homo sapiens cytochrome P450, family... 79 5e-14
AY288916-1|AAP31972.1| 508|Homo sapiens cytochrome P450, family... 79 5e-14
AF372573-1|AAL69652.1| 495|Homo sapiens cytochrome P450 2F1 pro... 79 5e-14
AF256213-1|AAG00416.1| 508|Homo sapiens 25- hydroxyvitamin D-1-... 79 5e-14
AF246895-1|AAF64299.1| 508|Homo sapiens 25-hydroxyvitamin D-1-a... 79 5e-14
AF027152-1|AAC51854.1| 508|Homo sapiens P450 25-hydroxyvitamin ... 79 5e-14
AF020192-1|AAC51853.1| 508|Homo sapiens 25-hydroxyvitamin D-1-a... 79 5e-14
AB006987-1|BAA23418.1| 508|Homo sapiens 25-hydroxyvitamin D3 1-... 79 5e-14
AB005990-1|BAA22657.1| 508|Homo sapiens 25-hydroxyvitamin D3 1a... 79 5e-14
AB005989-1|BAA22656.1| 508|Homo sapiens 25-hydroxyvitamin D3 1a... 79 5e-14
AB005038-1|BAA23416.1| 508|Homo sapiens 25-hydroxyvitamin D3 1-... 79 5e-14
BC106758-1|AAI06759.1| 497|Homo sapiens cytochrome P450, family... 78 6e-14
DQ282151-1|ABB77899.1| 496|Homo sapiens cytochrome P450 2D6 pro... 78 8e-14
J02906-1|AAA52156.1| 491|Homo sapiens CYP2F1 protein. 77 1e-13
DQ282162-1|ABB77909.1| 500|Homo sapiens cytochrome P450 2D6 pro... 77 1e-13
DQ282160-1|ABB77908.1| 497|Homo sapiens cytochrome P450 2D6 pro... 77 1e-13
DQ282159-1|ABB77907.1| 497|Homo sapiens cytochrome P450 2D6 pro... 77 1e-13
DQ282158-1|ABB77906.1| 497|Homo sapiens cytochrome P450 2D6 pro... 77 1e-13
DQ282157-1|ABB77905.1| 497|Homo sapiens cytochrome P450 2D6 pro... 77 1e-13
DQ282156-1|ABB77904.1| 497|Homo sapiens cytochrome P450 2D6 pro... 77 1e-13
DQ282155-1|ABB77903.1| 497|Homo sapiens cytochrome P450 2D6 pro... 77 1e-13
DQ282147-1|ABB77898.1| 497|Homo sapiens cytochrome P450 2D6 pro... 77 1e-13
CR456430-1|CAG30316.1| 446|Homo sapiens CYP2D6 protein. 77 1e-13
BC126858-1|AAI26859.1| 497|Homo sapiens cytochrome P450, family... 77 1e-13
BC106757-1|AAI06758.1| 446|Homo sapiens cytochrome P450, family... 77 1e-13
BC067432-1|AAH67432.1| 497|Homo sapiens cytochrome P450, family... 77 1e-13
BC066877-1|AAH66877.1| 446|Homo sapiens CYP2D6 protein protein. 77 1e-13
AY178622-1|AAO21126.1| 531|Homo sapiens steroid hydroxylase pro... 77 1e-13
BC067433-1|AAH67433.1| 493|Homo sapiens cytochrome P450, family... 77 1e-13
J02843-1|AAA52155.1| 493|Homo sapiens protein ( Human cytochrom... 77 2e-13
J02625-1|AAA35743.1| 493|Homo sapiens protein ( Human cytochrom... 77 2e-13
DQ515958-1|ABF47105.1| 493|Homo sapiens cytochrome P450, family... 77 2e-13
DQ282153-1|ABB77901.1| 497|Homo sapiens cytochrome P450 2D6 pro... 77 2e-13
DQ149222-1|AAZ77710.1| 493|Homo sapiens cytochrome P450 2E1 pro... 77 2e-13
BC067435-1|AAH67435.1| 493|Homo sapiens cytochrome P450, family... 77 2e-13
AL161645-2|CAH70047.1| 493|Homo sapiens cytochrome P450, family... 77 2e-13
AF182276-1|AAF13601.1| 493|Homo sapiens cytochrome P450-2E1 pro... 77 2e-13
AF084225-1|AAD13753.1| 462|Homo sapiens cytochrome P450 2E1 pro... 77 2e-13
X05367-1|CAA28965.1| 521|Homo sapiens desmolase protein. 75 6e-13
M28253-1|AAA36404.1| 239|Homo sapiens cytochrome P-450-scc prot... 75 6e-13
M14565-1|AAA52162.1| 521|Homo sapiens CYP11A protein. 75 6e-13
BC032329-1|AAH32329.1| 521|Homo sapiens cytochrome P450, family... 75 6e-13
BC096259-1|AAH96259.1| 443|Homo sapiens CYP2C18 protein protein. 75 8e-13
X51535-1|CAA35915.1| 210|Homo sapiens cytochrome P-450 HPH (120... 74 1e-12
BC010358-1|AAH10358.1| 469|Homo sapiens cytochrome P450, family... 74 1e-12
AL591242-1|CAH73899.1| 469|Homo sapiens cytochrome P450, family... 74 1e-12
AL035670-1|CAI20276.1| 469|Homo sapiens cytochrome P450, family... 74 1e-12
AF237982-1|AAF63329.1| 469|Homo sapiens oxysterol 7alpha-hydrox... 74 1e-12
M24667-1|AAA52148.1| 256|Homo sapiens steroid 11-beta-hydroxyla... 73 2e-12
BC025761-1|AAH25761.2| 490|Homo sapiens cytochrome P450, family... 73 3e-12
X55764-1|CAA39290.1| 503|Homo sapiens protein ( Human mRNA for ... 72 4e-12
X54741-1|CAA38539.1| 503|Homo sapiens aldosterone synthase (P-... 72 6e-12
X02612-1|CAA26458.1| 512|Homo sapiens cytochrome P(1)-450 protein. 72 6e-12
D13752-1|BAA02899.1| 503|Homo sapiens steroid 18-hydroxylase pr... 72 6e-12
AK223108-1|BAD96828.1| 512|Homo sapiens cytochrome P450, family... 72 6e-12
AF478474-1|AAL84813.1| 503|Homo sapiens mutated cytochrome P-45... 72 6e-12
X04300-1|CAA27843.1| 512|Homo sapiens P-450 c protein. 71 7e-12
M32879-1|AAA52149.1| 503|Homo sapiens CYP11B1 protein. 71 7e-12
M12079-1|AAA52152.1| 191|Homo sapiens POR protein. 71 7e-12
K03191-1|AAA52139.1| 512|Homo sapiens CYP1A1 protein. 71 7e-12
EF094025-1|ABK41999.1| 512|Homo sapiens cytochrome P450, family... 71 7e-12
BC096287-1|AAH96287.1| 503|Homo sapiens cytochrome P450, family... 71 7e-12
BC096285-1|AAH96285.1| 574|Homo sapiens CYP11B1 protein protein. 71 7e-12
BC023019-1|AAH23019.1| 512|Homo sapiens cytochrome P450, family... 71 7e-12
AY310359-1|AAQ76692.1| 484|Homo sapiens cytochrome P450 1A1 var... 71 7e-12
AM236047-1|CAJ84704.1| 251|Homo sapiens cytochrome P450 1A1 pro... 71 7e-12
AK223113-1|BAD96833.1| 512|Homo sapiens cytochrome P450, family... 71 7e-12
AF253322-1|AAK25727.1| 512|Homo sapiens cytochrome P450 protein. 71 7e-12
K03192-1|AAA52147.1| 331|Homo sapiens CYP1A1 protein. 71 1e-11
Y07508-1|CAA68807.1| 503|Homo sapiens protein ( Human mRNA for ... 71 1e-11
X13589-1|CAA31929.1| 503|Homo sapiens protein ( Human mRNA for ... 71 1e-11
M30804-1|AAA35728.1| 503|Homo sapiens protein ( Human aromatase... 71 1e-11
M28420-1|AAA52141.1| 419|Homo sapiens cytochrome P-450 aromatas... 71 1e-11
M22246-1|AAA35557.1| 503|Homo sapiens protein ( Human aromatase... 71 1e-11
M18856-1|AAA35556.1| 419|Homo sapiens protein ( Human aromatase... 71 1e-11
J04127-1|AAA52132.1| 503|Homo sapiens CYP19 protein. 71 1e-11
DQ118405-1|AAZ23558.1| 503|Homo sapiens cytochrome P450 subfami... 71 1e-11
BC107785-1|AAI07786.1| 503|Homo sapiens cytochrome P450, family... 71 1e-11
BC035959-1|AAH35959.1| 503|Homo sapiens cytochrome P450, family... 71 1e-11
AY957953-1|AAX44046.1| 503|Homo sapiens cytochrome P450, family... 71 1e-11
M32881-1|AAA35741.1| 503|Homo sapiens protein ( Human steroid 1... 69 3e-11
AB209700-1|BAD92937.1| 336|Homo sapiens cytochrome P450, family... 69 3e-11
L16883-1|AAD13467.1| 169|Homo sapiens cytochrome P-450 2C protein. 69 4e-11
BC067429-1|AAH67429.1| 516|Homo sapiens cytochrome P450, family... 69 4e-11
X58906-1|CAA41709.1| 495|Homo sapiens steroid 21-monooxygenase ... 68 7e-11
AM183949-1|CAJ75803.1| 494|Homo sapiens steroid 21-hydroxylase,... 67 2e-10
M26856-1|AAA52064.1| 495|Homo sapiens protein ( Human 21-hydrox... 66 2e-10
M13936-1|AAA59695.1| 494|Homo sapiens CYP21P protein. 66 2e-10
BX679671-8|CAM26071.1| 464|Homo sapiens cytochrome P450, family... 66 2e-10
BX679671-7|CAM26070.1| 494|Homo sapiens cytochrome P450, family... 66 2e-10
BC125182-1|AAI25183.1| 494|Homo sapiens cytochrome P450, family... 66 2e-10
BC125181-1|AAI25182.1| 495|Homo sapiens cytochrome P450, family... 66 2e-10
AM183951-1|CAJ75805.1| 494|Homo sapiens steroid 21-hydroxylase,... 66 2e-10
AM183947-1|CAJ75801.1| 494|Homo sapiens steroid 21-hydroxylase,... 66 2e-10
AM183946-1|CAJ75800.1| 494|Homo sapiens steroid 21-hydroxylase,... 66 2e-10
AM183945-1|CAJ75799.1| 494|Homo sapiens steroid 21-hydroxylase,... 66 2e-10
AM086565-1|CAJ31104.1| 494|Homo sapiens steroid 21-hydroxylase,... 66 2e-10
AM086564-1|CAJ31103.1| 494|Homo sapiens steroid 21-hydroxylase,... 66 2e-10
AL929593-2|CAI41778.1| 465|Homo sapiens cytochrome P450, family... 66 2e-10
AL929593-1|CAI41779.1| 495|Homo sapiens cytochrome P450, family... 66 2e-10
AL662849-19|CAI17480.1| 465|Homo sapiens cytochrome P450, famil... 66 2e-10
AL662849-18|CAI17479.1| 495|Homo sapiens cytochrome P450, famil... 66 2e-10
AL645922-24|CAI41754.1| 495|Homo sapiens cytochrome P450, famil... 66 2e-10
AL645922-23|CAI41755.1| 465|Homo sapiens cytochrome P450, famil... 66 2e-10
AL049547-7|CAB89301.1| 495|Homo sapiens dJ34F7.3 (cytochrome P4... 66 2e-10
AK054616-1|BAB70774.1| 465|Homo sapiens protein ( Homo sapiens ... 66 2e-10
AF077974-1|AAD45405.1| 403|Homo sapiens cytochrome P450 21-hydr... 66 2e-10
AF019413-2|AAB67982.1| 495|Homo sapiens cytochrome P450 21-hydr... 66 2e-10
M21550-1|AAA52063.1| 495|Homo sapiens CYP21 protein. 66 3e-10
Z00036-1|CAA77335.1| 515|Homo sapiens protein ( Human mRNA for ... 66 4e-10
M55053-1|AAA52146.1| 515|Homo sapiens cytochrome P3-450 protein. 66 4e-10
M31667-1|AAA52163.1| 515|Homo sapiens CYP1A2 protein. 66 4e-10
L00389-1|AAA35738.1| 516|Homo sapiens protein ( Human cytochrom... 66 4e-10
DQ022432-1|AAY26399.1| 516|Homo sapiens cytochrome P450, family... 66 4e-10
BC067428-1|AAH67428.1| 516|Homo sapiens cytochrome P450, family... 66 4e-10
BC067427-1|AAH67427.1| 516|Homo sapiens cytochrome P450, family... 66 4e-10
BC067426-1|AAH67426.1| 516|Homo sapiens cytochrome P450, family... 66 4e-10
BC067425-1|AAH67425.1| 516|Homo sapiens cytochrome P450, family... 66 4e-10
BC067424-1|AAH67424.1| 516|Homo sapiens cytochrome P450, family... 66 4e-10
AF253322-2|AAK25728.1| 516|Homo sapiens cytochrome P450 protein. 66 4e-10
M28548-1|AAA52065.1| 495|Homo sapiens protein ( Human mutant 21... 65 5e-10
AF182274-1|AAF13599.1| 516|Homo sapiens cytochrome P450-1A2 pro... 65 5e-10
M17252-1|AAA59985.1| 230|Homo sapiens CYP21 protein. 65 6e-10
AM233517-1|CAJ80720.1| 175|Homo sapiens cytochrome P450 1A1 pro... 65 6e-10
AY359068-1|AAQ89427.1| 462|Homo sapiens P450-like protein protein. 64 8e-10
AM183950-1|CAJ75804.1| 494|Homo sapiens steroid 21-hydroxylase,... 64 8e-10
AM183948-1|CAJ75802.1| 494|Homo sapiens steroid 21-hydroxylase ... 64 8e-10
AL358613-1|CAH72802.2| 522|Homo sapiens cytochrome P450, family... 64 8e-10
BC093022-1|AAH93022.1| 416|Homo sapiens CYP20A1 protein protein. 64 1e-09
BC033752-1|AAH33752.1| 462|Homo sapiens cytochrome P450, family... 64 1e-09
BC020616-1|AAH20616.1| 462|Homo sapiens cytochrome P450, family... 64 1e-09
AY356349-1|AAQ55485.1| 522|Homo sapiens cytochrome P450 protein. 64 1e-09
U56438-1|AAC50809.1| 543|Homo sapiens dioxin-inducible cytochro... 64 1e-09
U03688-1|AAA19567.1| 543|Homo sapiens cytochrome P450 protein. 64 1e-09
M12792-1|AAB59440.1| 494|Homo sapiens steroid 21-hydroxylase pr... 64 1e-09
BT020001-1|AAV38804.1| 543|Homo sapiens cytochrome P450, family... 64 1e-09
BC012049-1|AAH12049.1| 543|Homo sapiens cytochrome P450, family... 64 1e-09
AY393998-1|AAQ87875.1| 543|Homo sapiens cytochrome P450, family... 64 1e-09
AF450132-1|AAM50512.1| 543|Homo sapiens cytochrome P450 CYP1B1 ... 64 1e-09
AC009229-2|AAY15039.1| 543|Homo sapiens unknown protein. 64 1e-09
M80646-1|AAA60617.1| 460|Homo sapiens thromboxane synthase prot... 63 3e-09
AK127151-1|BAC86855.1| 146|Homo sapiens protein ( Homo sapiens ... 62 3e-09
AK000366-1|BAA91114.1| 408|Homo sapiens protein ( Homo sapiens ... 62 3e-09
M12078-1|AAA52154.1| 192|Homo sapiens POR protein. 62 6e-09
BT019979-1|AAV38782.1| 543|Homo sapiens cytochrome P450, family... 62 6e-09
AF183412-1|AAG09681.1| 435|Homo sapiens cytochrome P450 monooxy... 61 1e-08
AY220845-1|AAO49806.1| 516|Homo sapiens cytochrome P450 protein. 58 7e-08
AF040259-1|AAD10199.1| 144|Homo sapiens cytochrome P450 1A1 pro... 57 2e-07
DQ016495-1|AAY34975.1| 195|Homo sapiens cytochrome P450 1B1 pro... 56 3e-07
AJ877238-1|CAI47002.1| 97|Homo sapiens putative cytochrome P45... 54 1e-06
AF297052-1|AAG31785.1| 500|Homo sapiens prostacyclin synthase p... 54 1e-06
D84124-1|BAA28219.1| 509|Homo sapiens prostacyclin synthase pro... 53 2e-06
D83402-1|BAA11910.1| 500|Homo sapiens prostacyclin synthase pro... 53 2e-06
D38145-1|BAA07343.1| 500|Homo sapiens prostacyclin synthase pro... 53 2e-06
BC101811-1|AAI01812.1| 500|Homo sapiens prostaglandin I2 (prost... 53 2e-06
BC101809-1|AAI01810.1| 500|Homo sapiens prostaglandin I2 (prost... 53 2e-06
AL118525-1|CAC14162.1| 500|Homo sapiens prostaglandin I2 (prost... 53 2e-06
AF297051-1|AAG31784.1| 500|Homo sapiens prostacyclin synthase p... 53 2e-06
AF297050-1|AAG31783.1| 500|Homo sapiens prostacyclin synthase p... 53 2e-06
AF297049-1|AAG31782.1| 500|Homo sapiens prostacyclin synthase p... 53 2e-06
AF297048-1|AAG31781.1| 500|Homo sapiens prostacyclin synthase p... 53 2e-06
AC011737-1|AAX88915.1| 382|Homo sapiens unknown protein. 53 3e-06
AM233518-1|CAJ80721.1| 157|Homo sapiens cytochrome P450 1A1 pro... 52 4e-06
BC109084-1|AAI09085.1| 448|Homo sapiens CYP24A1 protein protein. 48 6e-05
BC109083-1|AAI09084.1| 448|Homo sapiens CYP24A1 protein protein. 48 6e-05
AL138805-2|CAM27343.1| 448|Homo sapiens cytochrome P450, family... 48 6e-05
X56088-1|CAA39568.1| 504|Homo sapiens cholesterol 7-alpha-hydr... 47 1e-04
M93133-1|AAA58435.1| 504|Homo sapiens cholesterol 7-alpha hydro... 47 1e-04
BC112184-1|AAI12185.1| 504|Homo sapiens cytochrome P450, family... 47 1e-04
BC101777-1|AAI01778.1| 504|Homo sapiens cytochrome P450, family... 47 1e-04
BC029155-1|AAH29155.1| 489|Homo sapiens Unknown (protein for IM... 44 0.001
AF176805-1|AAK11850.1| 506|Homo sapiens oxysterol 7alpha-hydrox... 44 0.001
AF127090-1|AAD20021.1| 506|Homo sapiens oxysterol 7alpha-hydrox... 44 0.001
AF029403-1|AAC95426.1| 506|Homo sapiens oxysterol 7alpha-hydrox... 44 0.001
DQ680079-1|ABG25922.1| 347|Homo sapiens truncated cytochrome P4... 44 0.001
AK127234-1|BAC86895.1| 130|Homo sapiens ). protein. 43 0.003
AY871801-1|AAX62803.1| 483|Homo sapiens cytochrome P450 family ... 42 0.005
L36085-1|AAC01761.1| 441|Homo sapiens thromboxane A2 synthase p... 41 0.009
AF280111-1|AAG33012.1| 250|Homo sapiens cytochrome P450 subfami... 41 0.012
X58904-1|CAA41707.1| 371|Homo sapiens steroid 21-monooxygenase ... 39 0.036
X58902-1|CAA41706.1| 372|Homo sapiens steroid 21-monooxygenase ... 39 0.036
X58900-1|CAA41704.1| 372|Homo sapiens steroid 21-monooxygenase ... 39 0.036
X58899-1|CAA41703.1| 368|Homo sapiens steroid 21-monooxygenase ... 39 0.036
X58898-1|CAA41702.1| 371|Homo sapiens steroid 21-monooxygenase ... 39 0.036
BC128535-1|AAI28536.1| 143|Homo sapiens LOC283480 protein protein. 39 0.048
AF144566-1|AAD30164.1| 339|Homo sapiens cytochrome P450 epoxyge... 39 0.048
AB209749-1|BAD92986.1| 210|Homo sapiens cytochrome P450, family... 39 0.048
M29873-1|AAA52143.1| 377|Homo sapiens CYP2B protein. 38 0.063
BC041174-1|AAH41174.1| 377|Homo sapiens CYP2B7P1 protein protein. 38 0.063
S77409-1|AAB34643.1| 228|Homo sapiens steroid 18-hydroxylase pr... 34 1.4
AJ563379-2|CAD91649.1| 84|Homo sapiens cytochrome P450 protein. 34 1.4
BC109056-1|AAI09057.1| 320|Homo sapiens CYP2F1 protein protein. 33 3.1
AC005336-2|AAC27731.1| 93|Homo sapiens F20191_1, partial CDS p... 33 3.1
AC004914-2|AAP21887.1| 311|Homo sapiens unknown protein. 32 4.1
AC004914-1|AAD21788.1| 348|Homo sapiens unknown protein. 32 4.1
BC096286-1|AAH96286.1| 437|Homo sapiens cytochrome P450, family... 31 9.6
AK094090-1|BAC04283.1| 153|Homo sapiens protein ( Homo sapiens ... 31 9.6
>BC060857-1|AAH60857.1| 525|Homo sapiens cytochrome P450, family 4,
subfamily V, polypeptide 2 protein.
Length = 525
Score = 214 bits (522), Expect = 7e-55
Identities = 103/230 (44%), Positives = 149/230 (64%), Gaps = 2/230 (0%)
Query: 269 EKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQ 328
+ KR AFLDL++ + + N++S +I+EEVDT MFEGHDTTAA ++ L LLG + +VQ
Sbjct: 293 KNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQ 352
Query: 329 ARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTKN 388
+V EL +FG SDRPAT D +++YLE VI E+LRL+P VP+ AR ++ D ++
Sbjct: 353 KKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVA--G 410
Query: 389 YVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGR 448
Y + GT VI + LHR P+Y+ +PE F P+ F PEN Q RH Y+Y+PFSAGPR+C+G+
Sbjct: 411 YRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQ 470
Query: 449 KYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEPR 498
K+A R+F S +E L+G +IL+ + G +K++ R
Sbjct: 471 KFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRR 520
Score = 140 bits (338), Expect = 1e-32
Identities = 68/184 (36%), Positives = 113/184 (61%), Gaps = 1/184 (0%)
Query: 30 VIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKPWLGEGLLISSGPKWRSHRK 89
++++W+G +V L +A+++E+IL S IDK++ Y+F +PWLG GLL S+G KWRS RK
Sbjct: 89 LLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWLGLGLLTSTGNKWRSRRK 148
Query: 90 MIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVG-KTFDVHDYMSGTTVDILLETAMGIS 148
M+ PTFH IL+ F+ I N+ +N +V+KL+ + + F+ Y++ +DI+ ETAMG +
Sbjct: 149 MLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEAFNCFFYITLCALDIICETAMGKN 208
Query: 149 RKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSEIVFKLTSFFKQQTKLLGIIHGLTNKV 208
Q +Y AV +M ++I +R W+ ++ + + + K L I+H TN V
Sbjct: 209 IGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLKILHTFTNSV 268
Query: 209 IKNK 212
I +
Sbjct: 269 IAER 272
>AY422002-1|AAR31180.1| 525|Homo sapiens cytochrome P450 4V2
protein.
Length = 525
Score = 214 bits (522), Expect = 7e-55
Identities = 103/230 (44%), Positives = 149/230 (64%), Gaps = 2/230 (0%)
Query: 269 EKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQ 328
+ KR AFLDL++ + + N++S +I+EEVDT MFEGHDTTAA ++ L LLG + +VQ
Sbjct: 293 KNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQ 352
Query: 329 ARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTKN 388
+V EL +FG SDRPAT D +++YLE VI E+LRL+P VP+ AR ++ D ++
Sbjct: 353 KKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVA--G 410
Query: 389 YVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGR 448
Y + GT VI + LHR P+Y+ +PE F P+ F PEN Q RH Y+Y+PFSAGPR+C+G+
Sbjct: 411 YRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQ 470
Query: 449 KYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEPR 498
K+A R+F S +E L+G +IL+ + G +K++ R
Sbjct: 471 KFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRR 520
Score = 140 bits (338), Expect = 1e-32
Identities = 68/184 (36%), Positives = 113/184 (61%), Gaps = 1/184 (0%)
Query: 30 VIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKPWLGEGLLISSGPKWRSHRK 89
++++W+G +V L +A+++E+IL S IDK++ Y+F +PWLG GLL S+G KWRS RK
Sbjct: 89 LLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWLGLGLLTSTGNKWRSRRK 148
Query: 90 MIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVG-KTFDVHDYMSGTTVDILLETAMGIS 148
M+ PTFH IL+ F+ I N+ +N +V+KL+ + + F+ Y++ +DI+ ETAMG +
Sbjct: 149 MLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEAFNCFFYITLCALDIICETAMGKN 208
Query: 149 RKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSEIVFKLTSFFKQQTKLLGIIHGLTNKV 208
Q +Y AV +M ++I +R W+ ++ + + + K L I+H TN V
Sbjct: 209 IGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLKILHTFTNSV 268
Query: 209 IKNK 212
I +
Sbjct: 269 IAER 272
>AK126473-1|BAC86562.1| 503|Homo sapiens protein ( Homo sapiens
cDNA FLJ44509 fis, clone UTERU3001585, weakly similar
to Cytochrome P450 4c3 (EC 1.14.-.-). ).
Length = 503
Score = 214 bits (522), Expect = 7e-55
Identities = 103/230 (44%), Positives = 149/230 (64%), Gaps = 2/230 (0%)
Query: 269 EKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQ 328
+ KR AFLDL++ + + N++S +I+EEVDT MFEGHDTTAA ++ L LLG + +VQ
Sbjct: 271 KNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQ 330
Query: 329 ARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTKN 388
+V EL +FG SDRPAT D +++YLE VI E+LRL+P VP+ AR ++ D ++
Sbjct: 331 KKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVA--G 388
Query: 389 YVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGR 448
Y + GT VI + LHR P+Y+ +PE F P+ F PEN Q RH Y+Y+PFSAGPR+C+G+
Sbjct: 389 YRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQ 448
Query: 449 KYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEPR 498
K+A R+F S +E L+G +IL+ + G +K++ R
Sbjct: 449 KFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRR 498
Score = 140 bits (338), Expect = 1e-32
Identities = 68/184 (36%), Positives = 113/184 (61%), Gaps = 1/184 (0%)
Query: 30 VIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKPWLGEGLLISSGPKWRSHRK 89
++++W+G +V L +A+++E+IL S IDK++ Y+F +PWLG GLL S+G KWRS RK
Sbjct: 67 LLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWLGLGLLTSTGNKWRSRRK 126
Query: 90 MIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVG-KTFDVHDYMSGTTVDILLETAMGIS 148
M+ PTFH IL+ F+ I N+ +N +V+KL+ + + F+ Y++ +DI+ ETAMG +
Sbjct: 127 MLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEAFNCFFYITLCALDIICETAMGKN 186
Query: 149 RKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSEIVFKLTSFFKQQTKLLGIIHGLTNKV 208
Q +Y AV +M ++I +R W+ ++ + + + K L I+H TN V
Sbjct: 187 IGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLKILHTFTNSV 246
Query: 209 IKNK 212
I +
Sbjct: 247 IAER 250
>AK122600-1|BAC85487.1| 525|Homo sapiens protein ( Homo sapiens
cDNA FLJ16007 fis, clone KIDNE2006580, weakly similar
to CYTOCHROME P450 4C1 (EC 1.14.14.1). ).
Length = 525
Score = 214 bits (522), Expect = 7e-55
Identities = 103/230 (44%), Positives = 149/230 (64%), Gaps = 2/230 (0%)
Query: 269 EKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQ 328
+ KR AFLDL++ + + N++S +I+EEVDT MFEGHDTTAA ++ L LLG + +VQ
Sbjct: 293 KNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQ 352
Query: 329 ARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTKN 388
+V EL +FG SDRPAT D +++YLE VI E+LRL+P VP+ AR ++ D ++
Sbjct: 353 KKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVA--G 410
Query: 389 YVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGR 448
Y + GT VI + LHR P+Y+ +PE F P+ F PEN Q RH Y+Y+PFSAGPR+C+G+
Sbjct: 411 YRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQ 470
Query: 449 KYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEPR 498
K+A R+F S +E L+G +IL+ + G +K++ R
Sbjct: 471 KFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRR 520
Score = 140 bits (338), Expect = 1e-32
Identities = 68/184 (36%), Positives = 113/184 (61%), Gaps = 1/184 (0%)
Query: 30 VIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKPWLGEGLLISSGPKWRSHRK 89
++++W+G +V L +A+++E+IL S IDK++ Y+F +PWLG GLL S+G KWRS RK
Sbjct: 89 LLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWLGLGLLTSTGNKWRSRRK 148
Query: 90 MIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVG-KTFDVHDYMSGTTVDILLETAMGIS 148
M+ PTFH IL+ F+ I N+ +N +V+KL+ + + F+ Y++ +DI+ ETAMG +
Sbjct: 149 MLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEAFNCFFYITLCALDIICETAMGKN 208
Query: 149 RKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSEIVFKLTSFFKQQTKLLGIIHGLTNKV 208
Q +Y AV +M ++I +R W+ ++ + + + K L I+H TN V
Sbjct: 209 IGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLKILHTFTNSV 268
Query: 209 IKNK 212
I +
Sbjct: 269 IAER 272
>AF133298-1|AAD49566.1| 520|Homo sapiens cytochrome P450 protein.
Length = 520
Score = 165 bits (401), Expect = 3e-40
Identities = 83/230 (36%), Positives = 129/230 (56%), Gaps = 4/230 (1%)
Query: 269 EKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQ 328
+ K L F+D+++ S ++SD +I+ E DT MF GHDTTA+G S+VL L H + Q
Sbjct: 292 KSKTLDFIDVLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQ 351
Query: 329 ARVYDELYQIFGDSD-RPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTK 387
R E+ ++ D + + + D ++ +L + ESLRL+PP+P AR +DV +
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDS 411
Query: 388 NYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVG 447
VIP G I F +H P + DPEV++P F PEN Q R ++IPFSAGPR+C+G
Sbjct: 412 R-VIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIG 470
Query: 448 RKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
+K+A FR + + +E + +I+L+ +G ++VEP
Sbjct: 471 QKFAMAEMKVVLALTLLRFRILPD--HREPRRTPEIVLRAEDGLWLRVEP 518
Score = 106 bits (255), Expect = 2e-22
Identities = 75/263 (28%), Positives = 131/263 (49%), Gaps = 16/263 (6%)
Query: 9 EENLTQKLVNLALGYAQTFGNVIRVWLGSKL-IVFLVDADDIEIILNSHVHI-DK-ATEY 65
EE L + L L Y Q F +R WLG I+ L D + ++N+ I DK Y
Sbjct: 71 EEGL-RVLTQLVATYPQGF---VR-WLGPITPIINLCHPDIVRSVINTSDAITDKDIVFY 125
Query: 66 RFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNV---VEKLKSEV 122
+ KPWLG+GLL+S G KWR HR+++ P FH NILK ++ IF++++N + ++L E
Sbjct: 126 KTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEG 185
Query: 123 GKTFDVHDYMSGTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSE 182
DV +++S T+D L + Q++ +Y A+M++ ++ +R+ +F+ +
Sbjct: 186 STCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPS-EYITAIMELSALVVKRNNQFFRYKD 244
Query: 183 IVFKLTSFFKQQTKLLGIIHGLTNKVIKNKKETYLENKAKGIIPPTLEEFTHHSGEILA- 241
++ LT ++ + ++H T+ VI+ ++ T + + T ++L
Sbjct: 245 FLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFIDVLLL 304
Query: 242 ---NNAKTLSDTVFKGYRDDLDF 261
N K LSD + D F
Sbjct: 305 SEDKNGKELSDEDIRAEADTFMF 327
>D26480-1|BAA05490.1| 520|Homo sapiens leukotriene B4
omega-hydroxylase protein.
Length = 520
Score = 163 bits (395), Expect = 2e-39
Identities = 84/230 (36%), Positives = 129/230 (56%), Gaps = 4/230 (1%)
Query: 269 EKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQ 328
+ K L F+D+++ S K+SD +I+ E DT MFEGHDTTA+G S+VL L H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351
Query: 329 ARVYDELYQIFGDSD-RPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTK 387
R E+ ++ D + + + D + +L + ESLRL+PPVPVI+R + +D+ +
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDG 411
Query: 388 NYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVG 447
VIP G +I F H P + DPEV++P F PEN + R ++IPFSAGPR+C+G
Sbjct: 412 R-VIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIG 470
Query: 448 RKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
+ +A FR + + E K +++L+ G ++VEP
Sbjct: 471 QTFAMAEMKVVLALTLLRFRVLPDHTEPRRK--PELVLRAEGGLWLRVEP 518
Score = 111 bits (266), Expect = 7e-24
Identities = 59/211 (27%), Positives = 114/211 (54%), Gaps = 7/211 (3%)
Query: 11 NLTQKLVNLALGYAQTFGNVIRVWLGS-KLIVFLVDADDIEIILNSHVHIDKATE--YRF 67
N T++ + + T+ +VW+G ++ L D I ++N+ I + Y F
Sbjct: 68 NPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSF 127
Query: 68 FKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEK---LKSEVGK 124
+PWLG+GLL+S+G KW HR+M+ P FH NILK ++ IFN++ N + K L SE
Sbjct: 128 LEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSA 187
Query: 125 TFDVHDYMSGTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSEIV 184
D+ +++S T+D L + Q++ +Y A++++ ++ +RH++ + + +
Sbjct: 188 CLDMFEHISLMTLDSLQKCVFSFDSHCQEKPS-EYIAAILELSALVSKRHHEILLHIDFL 246
Query: 185 FKLTSFFKQQTKLLGIIHGLTNKVIKNKKET 215
+ LT ++ + ++H T+ VI+ ++ T
Sbjct: 247 YYLTPDGQRFRRACRLVHDFTDAVIQERRRT 277
>BC067440-1|AAH67440.1| 520|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 2 protein.
Length = 520
Score = 163 bits (395), Expect = 2e-39
Identities = 84/230 (36%), Positives = 129/230 (56%), Gaps = 4/230 (1%)
Query: 269 EKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQ 328
+ K L F+D+++ S K+SD +I+ E DT MFEGHDTTA+G S+VL L H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351
Query: 329 ARVYDELYQIFGDSD-RPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTK 387
R E+ ++ D + + + D + +L + ESLRL+PPVPVI+R + +D+ +
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDG 411
Query: 388 NYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVG 447
VIP G +I F H P + DPEV++P F PEN + R ++IPFSAGPR+C+G
Sbjct: 412 R-VIPKGIICLISVFGTHHNPAMWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIG 470
Query: 448 RKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
+ +A FR + + E K +++L+ G ++VEP
Sbjct: 471 QTFAMAEMKVVLALTLLRFRVLPDHTEPRRK--PELVLRAEGGLWLRVEP 518
Score = 110 bits (264), Expect = 1e-23
Identities = 59/211 (27%), Positives = 113/211 (53%), Gaps = 7/211 (3%)
Query: 11 NLTQKLVNLALGYAQTFGNVIRVWLGS-KLIVFLVDADDIEIILNSHVHIDKATE--YRF 67
N T++ + + T+ +VW+G ++ L D I ++N+ I + Y F
Sbjct: 68 NPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSF 127
Query: 68 FKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEK---LKSEVGK 124
+PWLG+GLL+S+G KW HR+M+ P FH NILK ++ IFN + N + K L SE
Sbjct: 128 LEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNDSVNIMHAKWQLLASEGSA 187
Query: 125 TFDVHDYMSGTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSEIV 184
D+ +++S T+D L + Q++ +Y A++++ ++ +RH++ + + +
Sbjct: 188 CLDMFEHISLMTLDSLQKCVFSFDSHCQEKPS-EYIAAILELSALVSKRHHEILLHIDFL 246
Query: 185 FKLTSFFKQQTKLLGIIHGLTNKVIKNKKET 215
+ LT ++ + ++H T+ VI+ ++ T
Sbjct: 247 YYLTPDGQRFRRACRLVHDFTDAVIQERRRT 277
>BC067439-1|AAH67439.1| 520|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 2 protein.
Length = 520
Score = 163 bits (395), Expect = 2e-39
Identities = 84/230 (36%), Positives = 129/230 (56%), Gaps = 4/230 (1%)
Query: 269 EKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQ 328
+ K L F+D+++ S K+SD +I+ E DT MFEGHDTTA+G S+VL L H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351
Query: 329 ARVYDELYQIFGDSD-RPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTK 387
R E+ ++ D + + + D + +L + ESLRL+PPVPVI+R + +D+ +
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDG 411
Query: 388 NYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVG 447
VIP G +I F H P + DPEV++P F PEN + R ++IPFSAGPR+C+G
Sbjct: 412 R-VIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIG 470
Query: 448 RKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
+ +A FR + + E K +++L+ G ++VEP
Sbjct: 471 QTFAMAEMKVVLALTLLRFRVLPDHTEPRRK--PELVLRAEGGLWLRVEP 518
Score = 111 bits (266), Expect = 7e-24
Identities = 59/211 (27%), Positives = 114/211 (54%), Gaps = 7/211 (3%)
Query: 11 NLTQKLVNLALGYAQTFGNVIRVWLGS-KLIVFLVDADDIEIILNSHVHIDKATE--YRF 67
N T++ + + T+ +VW+G ++ L D I ++N+ I + Y F
Sbjct: 68 NPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSF 127
Query: 68 FKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEK---LKSEVGK 124
+PWLG+GLL+S+G KW HR+M+ P FH NILK ++ IFN++ N + K L SE
Sbjct: 128 LEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSA 187
Query: 125 TFDVHDYMSGTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSEIV 184
D+ +++S T+D L + Q++ +Y A++++ ++ +RH++ + + +
Sbjct: 188 CLDMFEHISLMTLDSLQKCVFSFDSHCQEKPS-EYIAAILELSALVSKRHHEILLHIDFL 246
Query: 185 FKLTSFFKQQTKLLGIIHGLTNKVIKNKKET 215
+ LT ++ + ++H T+ VI+ ++ T
Sbjct: 247 YYLTPDGQRFRRACRLVHDFTDAVIQERRRT 277
>BC067437-1|AAH67437.1| 520|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 2 protein.
Length = 520
Score = 163 bits (395), Expect = 2e-39
Identities = 84/230 (36%), Positives = 129/230 (56%), Gaps = 4/230 (1%)
Query: 269 EKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQ 328
+ K L F+D+++ S K+SD +I+ E DT MFEGHDTTA+G S+VL L H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351
Query: 329 ARVYDELYQIFGDSD-RPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTK 387
R E+ ++ D + + + D + +L + ESLRL+PPVPVI+R + +D+ +
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDG 411
Query: 388 NYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVG 447
VIP G +I F H P + DPEV++P F PEN + R ++IPFSAGPR+C+G
Sbjct: 412 R-VIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIG 470
Query: 448 RKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
+ +A FR + + E K +++L+ G ++VEP
Sbjct: 471 QTFAMAEMKVVLALTLLRFRVLPDHTEPRRK--PELVLRAEGGLWLRVEP 518
Score = 111 bits (266), Expect = 7e-24
Identities = 59/211 (27%), Positives = 114/211 (54%), Gaps = 7/211 (3%)
Query: 11 NLTQKLVNLALGYAQTFGNVIRVWLGS-KLIVFLVDADDIEIILNSHVHIDKATE--YRF 67
N T++ + + T+ +VW+G ++ L D I ++N+ I + Y F
Sbjct: 68 NPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSF 127
Query: 68 FKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEK---LKSEVGK 124
+PWLG+GLL+S+G KW HR+M+ P FH NILK ++ IFN++ N + K L SE
Sbjct: 128 LEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSA 187
Query: 125 TFDVHDYMSGTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSEIV 184
D+ +++S T+D L + Q++ +Y A++++ ++ +RH++ + + +
Sbjct: 188 CLDMFEHISLMTLDSLQKCVFSFDSHCQEKPS-EYIAAILELSALVSKRHHEILLHIDFL 246
Query: 185 FKLTSFFKQQTKLLGIIHGLTNKVIKNKKET 215
+ LT ++ + ++H T+ VI+ ++ T
Sbjct: 247 YYLTPDGQRFRRACRLVHDFTDAVIQERRRT 277
>AF467894-1|AAL67578.1| 520|Homo sapiens cytochrome P450, subfamily
IVF, polypeptide 2 protein.
Length = 520
Score = 163 bits (395), Expect = 2e-39
Identities = 84/230 (36%), Positives = 129/230 (56%), Gaps = 4/230 (1%)
Query: 269 EKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQ 328
+ K L F+D+++ S K+SD +I+ E DT MFEGHDTTA+G S+VL L H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351
Query: 329 ARVYDELYQIFGDSD-RPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTK 387
R E+ ++ D + + + D + +L + ESLRL+PPVPVI+R + +D+ +
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDG 411
Query: 388 NYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVG 447
VIP G +I F H P + DPEV++P F PEN + R ++IPFSAGPR+C+G
Sbjct: 412 R-VIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIG 470
Query: 448 RKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
+ +A FR + + E K +++L+ G ++VEP
Sbjct: 471 QTFAMAEMKVVLALTLLRFRVLPDHTEPRRK--PELVLRAEGGLWLRVEP 518
Score = 111 bits (266), Expect = 7e-24
Identities = 59/211 (27%), Positives = 114/211 (54%), Gaps = 7/211 (3%)
Query: 11 NLTQKLVNLALGYAQTFGNVIRVWLGS-KLIVFLVDADDIEIILNSHVHIDKATE--YRF 67
N T++ + + T+ +VW+G ++ L D I ++N+ I + Y F
Sbjct: 68 NPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSF 127
Query: 68 FKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEK---LKSEVGK 124
+PWLG+GLL+S+G KW HR+M+ P FH NILK ++ IFN++ N + K L SE
Sbjct: 128 LEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSA 187
Query: 125 TFDVHDYMSGTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSEIV 184
D+ +++S T+D L + Q++ +Y A++++ ++ +RH++ + + +
Sbjct: 188 CLDMFEHISLMTLDSLQKCVFSFDSHCQEKPS-EYIAAILELSALVSKRHHEILLHIDFL 246
Query: 185 FKLTSFFKQQTKLLGIIHGLTNKVIKNKKET 215
+ LT ++ + ++H T+ VI+ ++ T
Sbjct: 247 YYLTPDGQRFRRACRLVHDFTDAVIQERRRT 277
>AC005336-1|AAC27730.1| 520|Homo sapiens CYP4F2 protein.
Length = 520
Score = 163 bits (395), Expect = 2e-39
Identities = 84/230 (36%), Positives = 129/230 (56%), Gaps = 4/230 (1%)
Query: 269 EKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQ 328
+ K L F+D+++ S K+SD +I+ E DT MFEGHDTTA+G S+VL L H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351
Query: 329 ARVYDELYQIFGDSD-RPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTK 387
R E+ ++ D + + + D + +L + ESLRL+PPVPVI+R + +D+ +
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDG 411
Query: 388 NYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVG 447
VIP G +I F H P + DPEV++P F PEN + R ++IPFSAGPR+C+G
Sbjct: 412 R-VIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIG 470
Query: 448 RKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
+ +A FR + + E K +++L+ G ++VEP
Sbjct: 471 QTFAMAEMKVVLALTLLRFRVLPDHTEPRRK--PELVLRAEGGLWLRVEP 518
Score = 111 bits (266), Expect = 7e-24
Identities = 59/211 (27%), Positives = 114/211 (54%), Gaps = 7/211 (3%)
Query: 11 NLTQKLVNLALGYAQTFGNVIRVWLGS-KLIVFLVDADDIEIILNSHVHIDKATE--YRF 67
N T++ + + T+ +VW+G ++ L D I ++N+ I + Y F
Sbjct: 68 NPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSF 127
Query: 68 FKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEK---LKSEVGK 124
+PWLG+GLL+S+G KW HR+M+ P FH NILK ++ IFN++ N + K L SE
Sbjct: 128 LEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSA 187
Query: 125 TFDVHDYMSGTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSEIV 184
D+ +++S T+D L + Q++ +Y A++++ ++ +RH++ + + +
Sbjct: 188 CLDMFEHISLMTLDSLQKCVFSFDSHCQEKPS-EYIAAILELSALVSKRHHEILLHIDFL 246
Query: 185 FKLTSFFKQQTKLLGIIHGLTNKVIKNKKET 215
+ LT ++ + ++H T+ VI+ ++ T
Sbjct: 247 YYLTPDGQRFRRACRLVHDFTDAVIQERRRT 277
>AB015306-1|BAA75823.1| 520|Homo sapiens Leukotriene B4
omega-hydroxylase protein.
Length = 520
Score = 163 bits (395), Expect = 2e-39
Identities = 84/230 (36%), Positives = 129/230 (56%), Gaps = 4/230 (1%)
Query: 269 EKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQ 328
+ K L F+D+++ S K+SD +I+ E DT MFEGHDTTA+G S+VL L H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351
Query: 329 ARVYDELYQIFGDSD-RPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTK 387
R E+ ++ D + + + D + +L + ESLRL+PPVPVI+R + +D+ +
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDG 411
Query: 388 NYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVG 447
VIP G +I F H P + DPEV++P F PEN + R ++IPFSAGPR+C+G
Sbjct: 412 R-VIPKGIICLISVFGTHHNPAMWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIG 470
Query: 448 RKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
+ +A FR + + E K +++L+ G ++VEP
Sbjct: 471 QTFAMAEMKVVLALTLLRFRVLPDHTEPRRK--PELVLRAEGGLWLRVEP 518
Score = 111 bits (266), Expect = 7e-24
Identities = 59/211 (27%), Positives = 114/211 (54%), Gaps = 7/211 (3%)
Query: 11 NLTQKLVNLALGYAQTFGNVIRVWLGS-KLIVFLVDADDIEIILNSHVHIDKATE--YRF 67
N T++ + + T+ +VW+G ++ L D I ++N+ I + Y F
Sbjct: 68 NPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSF 127
Query: 68 FKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEK---LKSEVGK 124
+PWLG+GLL+S+G KW HR+M+ P FH NILK ++ IFN++ N + K L SE
Sbjct: 128 LEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSA 187
Query: 125 TFDVHDYMSGTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSEIV 184
D+ +++S T+D L + Q++ +Y A++++ ++ +RH++ + + +
Sbjct: 188 CLDMFEHISLMTLDSLQKCVFSFDSHCQEKPS-EYIAAILELSALVSKRHHEILLHIDFL 246
Query: 185 FKLTSFFKQQTKLLGIIHGLTNKVIKNKKET 215
+ LT ++ + ++H T+ VI+ ++ T
Sbjct: 247 YYLTPDGQRFRRACRLVHDFTDAVIQERRRT 277
>BC035350-1|AAH35350.1| 524|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 12 protein.
Length = 524
Score = 159 bits (386), Expect = 2e-38
Identities = 83/233 (35%), Positives = 130/233 (55%), Gaps = 4/233 (1%)
Query: 266 DVGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQ 325
D + K L F+D+++ S +SD +I+ E DT MF GHDTTA+G S+VL L H
Sbjct: 289 DKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHP 348
Query: 326 DVQARVYDELYQIFGDSD-RPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
+ Q R E+ ++ D D + + D ++ +L + ESLRL+PP P I+R +D+ +
Sbjct: 349 EYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVL 408
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
VIP G T +I +H P + DPEV++P F PEN++ R ++IPFSAGPR+
Sbjct: 409 PDGR-VIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRN 467
Query: 445 CVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
C+G+ +A +FR + + E KL ++I++ G ++VEP
Sbjct: 468 CIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKL--ELIMRAEGGLWLRVEP 518
Score = 109 bits (262), Expect = 2e-23
Identities = 58/196 (29%), Positives = 102/196 (52%), Gaps = 7/196 (3%)
Query: 26 TFGNVIRVWLGSKL-IVFLVDADDIEIILNSHVHIDKATEY--RFFKPWLGEGLLISSGP 82
T+ VWLG + + L D I I N+ I RF KPWLGEG+L+S G
Sbjct: 83 TYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGD 142
Query: 83 KWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEK---LKSEVGKTFDVHDYMSGTTVDI 139
KW HR+M+ P FH NILKS++ IFN+++N +++K L SE D+ +++S T+D
Sbjct: 143 KWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSCLDMFEHISLMTLDS 202
Query: 140 LLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSEIVFKLTSFFKQQTKLLG 199
L + Q+ +Y ++++ ++ +R + ++ L+ ++ +
Sbjct: 203 LQKCIFSFDSHCQERPS-EYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACR 261
Query: 200 IIHGLTNKVIKNKKET 215
++H T+ VI+ ++ T
Sbjct: 262 LVHDFTDAVIRERRRT 277
>AY792513-1|AAV40834.1| 520|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 3 protein.
Length = 520
Score = 159 bits (386), Expect = 2e-38
Identities = 82/230 (35%), Positives = 128/230 (55%), Gaps = 4/230 (1%)
Query: 269 EKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQ 328
+ K L F+D+++ S K+SD +I+ E DT MFEGHDTTA+G S+VL L H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351
Query: 329 ARVYDELYQIFGDSD-RPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTK 387
R E+ ++ D + + + D ++ +L I ESLRL+PPVP ++R +D+ +
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDG 411
Query: 388 NYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVG 447
VIP G +I F H P + DPEV++P F P+N + R ++IPFSAGPR+C+G
Sbjct: 412 R-VIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIG 470
Query: 448 RKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
+ +A FR + + E K +++L+ G ++VEP
Sbjct: 471 QAFAMAEMKVVLGLTLLRFRVLPDHTEPRRK--PELVLRAEGGLWLRVEP 518
Score = 106 bits (254), Expect = 2e-22
Identities = 69/218 (31%), Positives = 117/218 (53%), Gaps = 14/218 (6%)
Query: 5 IHVQEENLTQKLVNLALGYAQTFGNVIRVWLGS-KLIVFLVDADDIEIILNSHVHI---D 60
IH EE L L +L A TFG++ W+G IV + I+ +L + I D
Sbjct: 67 IHSSEEGL---LYTQSL--ACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPKD 121
Query: 61 KATEYRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEK--- 117
K Y F KPWLG+GLL+S+G KW HR+M+ P FH NILK ++ IFN++ N + K
Sbjct: 122 KVF-YSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQL 180
Query: 118 LKSEVGKTFDVHDYMSGTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKF 177
L SE D+ +++S T+D L + Q++ +Y A++++ ++ +RH +
Sbjct: 181 LASEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPS-EYIAAILELSALVTKRHQQI 239
Query: 178 WMRSEIVFKLTSFFKQQTKLLGIIHGLTNKVIKNKKET 215
+ + ++ LT ++ + ++H T+ VI+ ++ T
Sbjct: 240 LLYIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRT 277
>AY358977-1|AAQ89336.1| 524|Homo sapiens CYP4F12 protein.
Length = 524
Score = 159 bits (386), Expect = 2e-38
Identities = 83/233 (35%), Positives = 130/233 (55%), Gaps = 4/233 (1%)
Query: 266 DVGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQ 325
D + K L F+D+++ S +SD +I+ E DT MF GHDTTA+G S+VL L H
Sbjct: 289 DKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHP 348
Query: 326 DVQARVYDELYQIFGDSD-RPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
+ Q R E+ ++ D D + + D ++ +L + ESLRL+PP P I+R +D+ +
Sbjct: 349 EYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVL 408
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
VIP G T +I +H P + DPEV++P F PEN++ R ++IPFSAGPR+
Sbjct: 409 PDGR-VIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRN 467
Query: 445 CVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
C+G+ +A +FR + + E KL ++I++ G ++VEP
Sbjct: 468 CIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKL--ELIMRAEGGLWLRVEP 518
Score = 109 bits (262), Expect = 2e-23
Identities = 58/196 (29%), Positives = 102/196 (52%), Gaps = 7/196 (3%)
Query: 26 TFGNVIRVWLGSKL-IVFLVDADDIEIILNSHVHIDKATEY--RFFKPWLGEGLLISSGP 82
T+ VWLG + + L D I I N+ I RF KPWLGEG+L+S G
Sbjct: 83 TYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGD 142
Query: 83 KWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEK---LKSEVGKTFDVHDYMSGTTVDI 139
KW HR+M+ P FH NILKS++ IFN+++N +++K L SE D+ +++S T+D
Sbjct: 143 KWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDS 202
Query: 140 LLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSEIVFKLTSFFKQQTKLLG 199
L + Q+ +Y ++++ ++ +R + ++ L+ ++ +
Sbjct: 203 LQKCIFSFDSHCQERPS-EYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACR 261
Query: 200 IIHGLTNKVIKNKKET 215
++H T+ VI+ ++ T
Sbjct: 262 LVHDFTDAVIRERRRT 277
>AY008841-1|AAG33247.1| 524|Homo sapiens cytochrome P450 isoform
4F12 protein.
Length = 524
Score = 159 bits (386), Expect = 2e-38
Identities = 83/233 (35%), Positives = 130/233 (55%), Gaps = 4/233 (1%)
Query: 266 DVGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQ 325
D + K L F+D+++ S +SD +I+ E DT MF GHDTTA+G S+VL L H
Sbjct: 289 DKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHP 348
Query: 326 DVQARVYDELYQIFGDSD-RPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
+ Q R E+ ++ D D + + D ++ +L + ESLRL+PP P I+R +D+ +
Sbjct: 349 EYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVL 408
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
VIP G T +I +H P + DPEV++P F PEN++ R ++IPFSAGPR+
Sbjct: 409 PDGR-VIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRN 467
Query: 445 CVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
C+G+ +A +FR + + E KL ++I++ G ++VEP
Sbjct: 468 CIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKL--ELIMRAEGGLWLRVEP 518
Score = 109 bits (262), Expect = 2e-23
Identities = 58/196 (29%), Positives = 102/196 (52%), Gaps = 7/196 (3%)
Query: 26 TFGNVIRVWLGSKL-IVFLVDADDIEIILNSHVHIDKATEY--RFFKPWLGEGLLISSGP 82
T+ VWLG + + L D I I N+ I RF KPWLGEG+L+S G
Sbjct: 83 TYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGD 142
Query: 83 KWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEK---LKSEVGKTFDVHDYMSGTTVDI 139
KW HR+M+ P FH NILKS++ IFN+++N +++K L SE D+ +++S T+D
Sbjct: 143 KWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDS 202
Query: 140 LLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSEIVFKLTSFFKQQTKLLG 199
L + Q+ +Y ++++ ++ +R + ++ L+ ++ +
Sbjct: 203 LQKCIFSFDSHCQERPS-EYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACR 261
Query: 200 IIHGLTNKVIKNKKET 215
++H T+ VI+ ++ T
Sbjct: 262 LVHDFTDAVIRERRRT 277
>AF054821-1|AAC08589.1| 520|Homo sapiens cytochrome P-450 protein.
Length = 520
Score = 159 bits (386), Expect = 2e-38
Identities = 82/230 (35%), Positives = 128/230 (55%), Gaps = 4/230 (1%)
Query: 269 EKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQ 328
+ K L F+D+++ S K+SD +I+ E DT MFEGHDTTA+G S+VL L H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351
Query: 329 ARVYDELYQIFGDSD-RPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTK 387
R E+ ++ D + + + D ++ +L I ESLRL+PPVP ++R +D+ +
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDG 411
Query: 388 NYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVG 447
VIP G +I F H P + DPEV++P F P+N + R ++IPFSAGPR+C+G
Sbjct: 412 R-VIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIG 470
Query: 448 RKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
+ +A FR + + E K +++L+ G ++VEP
Sbjct: 471 QAFAMAEMKVVLGLTLLRFRVLPDHTEPRRK--PELVLRAEGGIWLRVEP 518
Score = 103 bits (247), Expect = 1e-21
Identities = 57/197 (28%), Positives = 107/197 (54%), Gaps = 9/197 (4%)
Query: 26 TFGNVIRVWLGSKL-IVFLVDADDIEIILNSHVHI---DKATEYRFFKPWLGEGLLISSG 81
T+ +VW+G ++ + I ++N+ I DK Y F KPWLG+GLL+S+G
Sbjct: 83 TYPQGFKVWMGPIFPVIRFCHPNIIRSVINASAAIVPKDKVF-YSFLKPWLGDGLLLSAG 141
Query: 82 PKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEK---LKSEVGKTFDVHDYMSGTTVD 138
KW HR+M+ P FH NILK ++ IFN++ N + K L S+ D+ +++S T+D
Sbjct: 142 EKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASKGYARLDMFEHISLMTLD 201
Query: 139 ILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSEIVFKLTSFFKQQTKLL 198
L + Q++ +Y A++++ ++ +RH + + + ++ LT ++ +
Sbjct: 202 SLQKCVFSFDSHCQEKPS-EYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFRRAC 260
Query: 199 GIIHGLTNKVIKNKKET 215
++H T+ VI+ ++ T
Sbjct: 261 RLVHDFTDAVIQERRRT 277
>AC004523-1|AAC11543.1| 458|Homo sapiens F22329_1 protein.
Length = 458
Score = 159 bits (386), Expect = 2e-38
Identities = 83/233 (35%), Positives = 130/233 (55%), Gaps = 4/233 (1%)
Query: 266 DVGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQ 325
D + K L F+D+++ S +SD +I+ E DT MF GHDTTA+G S+VL L H
Sbjct: 223 DKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHP 282
Query: 326 DVQARVYDELYQIFGDSD-RPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
+ Q R E+ ++ D D + + D ++ +L + ESLRL+PP P I+R +D+ +
Sbjct: 283 EYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVL 342
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
VIP G T +I +H P + DPEV++P F PEN++ R ++IPFSAGPR+
Sbjct: 343 PDGR-VIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRN 401
Query: 445 CVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
C+G+ +A +FR + + E KL ++I++ G ++VEP
Sbjct: 402 CIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKL--ELIMRAEGGLWLRVEP 452
Score = 109 bits (261), Expect = 3e-23
Identities = 57/196 (29%), Positives = 102/196 (52%), Gaps = 7/196 (3%)
Query: 26 TFGNVIRVWLGSKL-IVFLVDADDIEIILNSHVHIDKATEY--RFFKPWLGEGLLISSGP 82
T+ +WLG + + L D I I N+ I RF KPWLGEG+L+S G
Sbjct: 17 TYSQGFTIWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGD 76
Query: 83 KWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEK---LKSEVGKTFDVHDYMSGTTVDI 139
KW HR+M+ P FH NILKS++ IFN+++N +++K L SE D+ +++S T+D
Sbjct: 77 KWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSCLDMFEHISLMTLDS 136
Query: 140 LLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSEIVFKLTSFFKQQTKLLG 199
L + Q+ +Y ++++ ++ +R + ++ L+ ++ +
Sbjct: 137 LQKCIFSFDSHCQERPS-EYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACR 195
Query: 200 IIHGLTNKVIKNKKET 215
++H T+ VI+ ++ T
Sbjct: 196 LVHDFTDAVIRERRRT 211
>AB035131-1|BAB18270.1| 524|Homo sapiens cytochrome P450 protein.
Length = 524
Score = 159 bits (386), Expect = 2e-38
Identities = 83/233 (35%), Positives = 130/233 (55%), Gaps = 4/233 (1%)
Query: 266 DVGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQ 325
D + K L F+D+++ S +SD +I+ E DT MF GHDTTA+G S+VL L H
Sbjct: 289 DKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHP 348
Query: 326 DVQARVYDELYQIFGDSD-RPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
+ Q R E+ ++ D D + + D ++ +L + ESLRL+PP P I+R +D+ +
Sbjct: 349 EYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVL 408
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
VIP G T +I +H P + DPEV++P F PEN++ R ++IPFSAGPR+
Sbjct: 409 PDGR-VIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRN 467
Query: 445 CVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
C+G+ +A +FR + + E KL ++I++ G ++VEP
Sbjct: 468 CIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKL--ELIMRAEGGLWLRVEP 518
Score = 109 bits (262), Expect = 2e-23
Identities = 58/196 (29%), Positives = 102/196 (52%), Gaps = 7/196 (3%)
Query: 26 TFGNVIRVWLGSKL-IVFLVDADDIEIILNSHVHIDKATEY--RFFKPWLGEGLLISSGP 82
T+ VWLG + + L D I I N+ I RF KPWLGEG+L+S G
Sbjct: 83 TYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGD 142
Query: 83 KWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEK---LKSEVGKTFDVHDYMSGTTVDI 139
KW HR+M+ P FH NILKS++ IFN+++N +++K L SE D+ +++S T+D
Sbjct: 143 KWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDS 202
Query: 140 LLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSEIVFKLTSFFKQQTKLLG 199
L + Q+ +Y ++++ ++ +R + ++ L+ ++ +
Sbjct: 203 LQKCIFSFDSHCQERPS-EYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACR 261
Query: 200 IIHGLTNKVIKNKKET 215
++H T+ VI+ ++ T
Sbjct: 262 LVHDFTDAVIRERRRT 277
>AB035130-1|BAB18269.1| 524|Homo sapiens cytochrome P450 protein.
Length = 524
Score = 159 bits (386), Expect = 2e-38
Identities = 83/233 (35%), Positives = 130/233 (55%), Gaps = 4/233 (1%)
Query: 266 DVGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQ 325
D + K L F+D+++ S +SD +I+ E DT MF GHDTTA+G S+VL L H
Sbjct: 289 DKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHP 348
Query: 326 DVQARVYDELYQIFGDSD-RPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
+ Q R E+ ++ D D + + D ++ +L + ESLRL+PP P I+R +D+ +
Sbjct: 349 EYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVL 408
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
VIP G T +I +H P + DPEV++P F PEN++ R ++IPFSAGPR+
Sbjct: 409 PDGR-VIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRN 467
Query: 445 CVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
C+G+ +A +FR + + E KL ++I++ G ++VEP
Sbjct: 468 CIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKL--ELIMRAEGGLWLRVEP 518
Score = 109 bits (262), Expect = 2e-23
Identities = 58/196 (29%), Positives = 102/196 (52%), Gaps = 7/196 (3%)
Query: 26 TFGNVIRVWLGSKL-IVFLVDADDIEIILNSHVHIDKATEY--RFFKPWLGEGLLISSGP 82
T+ VWLG + + L D I I N+ I RF KPWLGEG+L+S G
Sbjct: 83 TYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGD 142
Query: 83 KWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEK---LKSEVGKTFDVHDYMSGTTVDI 139
KW HR+M+ P FH NILKS++ IFN+++N +++K L SE D+ +++S T+D
Sbjct: 143 KWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDS 202
Query: 140 LLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSEIVFKLTSFFKQQTKLLG 199
L + Q+ +Y ++++ ++ +R + ++ L+ ++ +
Sbjct: 203 LQKCIFSFDSHCQERPS-EYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACR 261
Query: 200 IIHGLTNKVIKNKKET 215
++H T+ VI+ ++ T
Sbjct: 262 LVHDFTDAVIRERRRT 277
>D12620-1|BAA02144.1| 520|Homo sapiens cytochrome P-450LTBV
protein.
Length = 520
Score = 158 bits (384), Expect = 4e-38
Identities = 82/230 (35%), Positives = 128/230 (55%), Gaps = 4/230 (1%)
Query: 269 EKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQ 328
+ K L F+D+++ S K+SD +I+ E DT MFEGHDTTA+G S+VL L H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351
Query: 329 ARVYDELYQIFGDSD-RPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTK 387
R E+ ++ D + + + D ++ +L I ESLRL+PPVP ++R +D+ +
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDG 411
Query: 388 NYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVG 447
VIP G +I F H P + DPEV++P F P+N + R ++IPFSAGPR+C+G
Sbjct: 412 R-VIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIG 470
Query: 448 RKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
+ +A FR + + E K +++L+ G ++VEP
Sbjct: 471 QAFAMAEMKVVLGLTLLAFRVLPDHTEPRRK--PELVLRAEGGLWLRVEP 518
Score = 106 bits (254), Expect = 2e-22
Identities = 69/218 (31%), Positives = 117/218 (53%), Gaps = 14/218 (6%)
Query: 5 IHVQEENLTQKLVNLALGYAQTFGNVIRVWLGS-KLIVFLVDADDIEIILNSHVHI---D 60
IH EE L L +L A TFG++ W+G IV + I+ +L + I D
Sbjct: 67 IHSSEEGL---LYTQSL--ACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPKD 121
Query: 61 KATEYRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEK--- 117
K Y F KPWLG+GLL+S+G KW HR+M+ P FH NILK ++ IFN++ N + K
Sbjct: 122 KVF-YSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQL 180
Query: 118 LKSEVGKTFDVHDYMSGTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKF 177
L SE D+ +++S T+D L + Q++ +Y A++++ ++ +RH +
Sbjct: 181 LASEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPS-EYIAAILELSALVTKRHQQI 239
Query: 178 WMRSEIVFKLTSFFKQQTKLLGIIHGLTNKVIKNKKET 215
+ + ++ LT ++ + ++H T+ VI+ ++ T
Sbjct: 240 LLYIDFLYYLTPDGQRFRRACRLVHDFTDDVIQERRRT 277
>AB002461-1|BAA25991.1| 520|Homo sapiens leukotriene B4
omega-hydroxylase protein.
Length = 520
Score = 158 bits (384), Expect = 4e-38
Identities = 82/230 (35%), Positives = 128/230 (55%), Gaps = 4/230 (1%)
Query: 269 EKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQ 328
+ K L F+D+++ S K+SD +I+ E DT MFEGHDTTA+G S+VL L H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351
Query: 329 ARVYDELYQIFGDSD-RPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTK 387
R E+ ++ D + + + D ++ +L I ESLRL+PPVP ++R +D+ +
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDG 411
Query: 388 NYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVG 447
VIP G +I F H P + DPEV++P F P+N + R ++IPFSAGPR+C+G
Sbjct: 412 R-VIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIG 470
Query: 448 RKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
+ +A FR + + E K +++L+ G ++VEP
Sbjct: 471 QAFAMAEMKVVLGLTLLAFRVLPDHTEPRRK--PELVLRAEGGLWLRVEP 518
Score = 106 bits (254), Expect = 2e-22
Identities = 69/218 (31%), Positives = 117/218 (53%), Gaps = 14/218 (6%)
Query: 5 IHVQEENLTQKLVNLALGYAQTFGNVIRVWLGS-KLIVFLVDADDIEIILNSHVHI---D 60
IH EE L L +L A TFG++ W+G IV + I+ +L + I D
Sbjct: 67 IHSSEEGL---LYTQSL--ACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPKD 121
Query: 61 KATEYRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEK--- 117
K Y F KPWLG+GLL+S+G KW HR+M+ P FH NILK ++ IFN++ N + K
Sbjct: 122 KVF-YSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQL 180
Query: 118 LKSEVGKTFDVHDYMSGTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKF 177
L SE D+ +++S T+D L + Q++ +Y A++++ ++ +RH +
Sbjct: 181 LASEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPS-EYIAAILELSALVTKRHQQI 239
Query: 178 WMRSEIVFKLTSFFKQQTKLLGIIHGLTNKVIKNKKET 215
+ + ++ LT ++ + ++H T+ VI+ ++ T
Sbjct: 240 LLYIDFLYYLTPDGQRFRRACRLVHDFTDDVIQERRRT 277
>AB002454-1|BAA25990.1| 520|Homo sapiens leukotriene B4
omega-hydroxylase protein.
Length = 520
Score = 158 bits (384), Expect = 4e-38
Identities = 82/230 (35%), Positives = 128/230 (55%), Gaps = 4/230 (1%)
Query: 269 EKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQ 328
+ K L F+D+++ S K+SD +I+ E DT MFEGHDTTA+G S+VL L H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351
Query: 329 ARVYDELYQIFGDSD-RPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTK 387
R E+ ++ D + + + D ++ +L I ESLRL+PPVP ++R +D+ +
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDG 411
Query: 388 NYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVG 447
VIP G +I F H P + DPEV++P F P+N + R ++IPFSAGPR+C+G
Sbjct: 412 R-VIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIG 470
Query: 448 RKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
+ +A FR + + E K +++L+ G ++VEP
Sbjct: 471 QAFAMAEMKVVLGLTLLAFRVLPDHTEPRRK--PELVLRAEGGLWLRVEP 518
Score = 106 bits (254), Expect = 2e-22
Identities = 69/218 (31%), Positives = 117/218 (53%), Gaps = 14/218 (6%)
Query: 5 IHVQEENLTQKLVNLALGYAQTFGNVIRVWLGS-KLIVFLVDADDIEIILNSHVHI---D 60
IH EE L L +L A TFG++ W+G IV + I+ +L + I D
Sbjct: 67 IHSSEEGL---LYTQSL--ACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPKD 121
Query: 61 KATEYRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEK--- 117
K Y F KPWLG+GLL+S+G KW HR+M+ P FH NILK ++ IFN++ N + K
Sbjct: 122 KVF-YSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQL 180
Query: 118 LKSEVGKTFDVHDYMSGTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKF 177
L SE D+ +++S T+D L + Q++ +Y A++++ ++ +RH +
Sbjct: 181 LASEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPS-EYIAAILELSALVTKRHQQI 239
Query: 178 WMRSEIVFKLTSFFKQQTKLLGIIHGLTNKVIKNKKET 215
+ + ++ LT ++ + ++H T+ VI+ ++ T
Sbjct: 240 LLYIDFLYYLTPDGQRFRRACRLVHDFTDDVIQERRRT 277
>U02388-1|AAC50052.2| 520|Homo sapiens cytochrome P450 4F2 protein.
Length = 520
Score = 158 bits (383), Expect = 5e-38
Identities = 82/230 (35%), Positives = 128/230 (55%), Gaps = 4/230 (1%)
Query: 269 EKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQ 328
+ K L F+D+++ S K+SD +I+ E DT MFEGHDTTA+ S+VL L H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASVLSWVLYHLAKHPEYQ 351
Query: 329 ARVYDELYQIFGDSD-RPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTK 387
R E+ ++ D + + + D + +L + ESLR++PPVPVI+R + +D+ +
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRVHPPVPVISRHVTQDIVLPDG 411
Query: 388 NYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVG 447
VIP G +I F H P + DPEV++P F PEN + R ++IPFSAGPR+C+G
Sbjct: 412 R-VIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIG 470
Query: 448 RKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
+ +A FR + + E K +++L+ G ++VEP
Sbjct: 471 QTFAMAEMKVVLALTLLRFRVLPDHTEPRRK--PELVLRAEGGLWLRVEP 518
Score = 111 bits (266), Expect = 7e-24
Identities = 59/211 (27%), Positives = 114/211 (54%), Gaps = 7/211 (3%)
Query: 11 NLTQKLVNLALGYAQTFGNVIRVWLGS-KLIVFLVDADDIEIILNSHVHIDKATE--YRF 67
N T++ + + T+ +VW+G ++ L D I ++N+ I + Y F
Sbjct: 68 NPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSF 127
Query: 68 FKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEK---LKSEVGK 124
+PWLG+GLL+S+G KW HR+M+ P FH NILK ++ IFN++ N + K L SE
Sbjct: 128 LEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSA 187
Query: 125 TFDVHDYMSGTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSEIV 184
D+ +++S T+D L + Q++ +Y A++++ ++ +RH++ + + +
Sbjct: 188 CLDMFEHISLMTLDSLQKCVFSFDSHCQEKPS-EYIAAILELSALVSKRHHEILLHIDFL 246
Query: 185 FKLTSFFKQQTKLLGIIHGLTNKVIKNKKET 215
+ LT ++ + ++H T+ VI+ ++ T
Sbjct: 247 YYLTPDGQRFRRACRLVHDFTDAVIQERRRT 277
>X16699-1|CAA34672.1| 511|Homo sapiens protein ( Human mRNA for
cytochrome P-450HP. ).
Length = 511
Score = 155 bits (376), Expect = 3e-37
Identities = 79/231 (34%), Positives = 129/231 (55%), Gaps = 3/231 (1%)
Query: 267 VGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQD 326
+ ++ L FLD+++ + K+SD +++ EVDT MFEGHDTT +G S+ L + ++ +
Sbjct: 277 IQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPE 336
Query: 327 VQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTIST 386
Q R +E+ +I GD D + D +M YL I ES RLYPPVP + R+L++ VT
Sbjct: 337 HQHRCREEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF-V 394
Query: 387 KNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV 446
+PAG+ + + + LHR + DPEVF+ F EN RH ++++PFSAGPR+C+
Sbjct: 395 DGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCI 454
Query: 447 GRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
G+++A F + K+ ++L+ GF + ++P
Sbjct: 455 GQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMP-QLVLRSKNGFHLHLKP 504
Score = 95.1 bits (226), Expect = 5e-19
Identities = 54/220 (24%), Positives = 103/220 (46%), Gaps = 6/220 (2%)
Query: 5 IHVQEENLTQKLVNLALGYAQTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATE 64
+ +QE K+V+ +A F +W G + + D + S
Sbjct: 59 LEIQETGSLDKVVS----WAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDV 114
Query: 65 YRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKL--KSEV 122
Y FF W+G GLL+ GPKW HRK++ P FH ++LK +V +F +++ +++K K+
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 123 GKTFDVHDYMSGTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSE 182
GK+FD+ + ++ L++ G Y +AV + ++ QR F ++
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHND 234
Query: 183 IVFKLTSFFKQQTKLLGIIHGLTNKVIKNKKETYLENKAK 222
++ LT ++ + + H T++VI+ +K + K +
Sbjct: 235 FIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVR 274
>J02871-1|AAA35712.1| 511|Homo sapiens protein ( Human lung
cytochrome P450 (IV subfamily) BI protein, complete cds.
).
Length = 511
Score = 155 bits (376), Expect = 3e-37
Identities = 79/231 (34%), Positives = 129/231 (55%), Gaps = 3/231 (1%)
Query: 267 VGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQD 326
+ ++ L FLD+++ + K+SD +++ EVDT MFEGHDTT +G S+ L + ++ +
Sbjct: 277 IQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPE 336
Query: 327 VQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTIST 386
Q R +E+ +I GD D + D +M YL I ES RLYPPVP + R+L++ VT
Sbjct: 337 HQHRCREEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF-V 394
Query: 387 KNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV 446
+PAG+ + + + LHR + DPEVF+ F EN RH ++++PFSAGPR+C+
Sbjct: 395 DGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCI 454
Query: 447 GRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
G+++A F + K+ ++L+ GF + ++P
Sbjct: 455 GQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMP-QLVLRSKNGFHLHLKP 504
Score = 95.1 bits (226), Expect = 5e-19
Identities = 54/220 (24%), Positives = 103/220 (46%), Gaps = 6/220 (2%)
Query: 5 IHVQEENLTQKLVNLALGYAQTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATE 64
+ +QE K+V+ +A F +W G + + D + S
Sbjct: 59 LEIQETGSLDKVVS----WAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDV 114
Query: 65 YRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKL--KSEV 122
Y FF W+G GLL+ GPKW HRK++ P FH ++LK +V +F +++ +++K K+
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 123 GKTFDVHDYMSGTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSE 182
GK+FD+ + ++ L++ G Y +AV + ++ QR F ++
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHND 234
Query: 183 IVFKLTSFFKQQTKLLGIIHGLTNKVIKNKKETYLENKAK 222
++ LT ++ + + H T++VI+ +K + K +
Sbjct: 235 FIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVR 274
>DQ518907-1|ABF47106.1| 511|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 511
Score = 155 bits (376), Expect = 3e-37
Identities = 79/231 (34%), Positives = 129/231 (55%), Gaps = 3/231 (1%)
Query: 267 VGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQD 326
+ ++ L FLD+++ + K+SD +++ EVDT MFEGHDTT +G S+ L + ++ +
Sbjct: 277 IQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPE 336
Query: 327 VQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTIST 386
Q R +E+ +I GD D + D +M YL I ES RLYPPVP + R+L++ VT
Sbjct: 337 HQHRCREEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF-V 394
Query: 387 KNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV 446
+PAG+ + + + LHR + DPEVF+ F EN RH ++++PFSAGPR+C+
Sbjct: 395 DGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCI 454
Query: 447 GRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
G+++A F + K+ ++L+ GF + ++P
Sbjct: 455 GQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMP-QLVLRSKNGFHLHLKP 504
Score = 95.1 bits (226), Expect = 5e-19
Identities = 54/220 (24%), Positives = 103/220 (46%), Gaps = 6/220 (2%)
Query: 5 IHVQEENLTQKLVNLALGYAQTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATE 64
+ +QE K+V+ +A F +W G + + D + S
Sbjct: 59 LEIQETGSLDKVVS----WAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDV 114
Query: 65 YRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKL--KSEV 122
Y FF W+G GLL+ GPKW HRK++ P FH ++LK +V +F +++ +++K K+
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 123 GKTFDVHDYMSGTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSE 182
GK+FD+ + ++ L++ G Y +AV + ++ QR F ++
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHND 234
Query: 183 IVFKLTSFFKQQTKLLGIIHGLTNKVIKNKKETYLENKAK 222
++ LT ++ + + H T++VI+ +K + K +
Sbjct: 235 FIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVR 274
>BC017758-1|AAH17758.1| 512|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 512
Score = 155 bits (376), Expect = 3e-37
Identities = 79/231 (34%), Positives = 129/231 (55%), Gaps = 3/231 (1%)
Query: 267 VGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQD 326
+ ++ L FLD+++ + K+SD +++ EVDT MFEGHDTT +G S+ L + ++ +
Sbjct: 278 IQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPE 337
Query: 327 VQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTIST 386
Q R +E+ +I GD D + D +M YL I ES RLYPPVP + R+L++ VT
Sbjct: 338 HQHRCREEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF-V 395
Query: 387 KNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV 446
+PAG+ + + + LHR + DPEVF+ F EN RH ++++PFSAGPR+C+
Sbjct: 396 DGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCI 455
Query: 447 GRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
G+++A F + K+ ++L+ GF + ++P
Sbjct: 456 GQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMP-QLVLRSKNGFHLHLKP 505
Score = 92.7 bits (220), Expect = 3e-18
Identities = 55/221 (24%), Positives = 104/221 (47%), Gaps = 7/221 (3%)
Query: 5 IHVQEENLTQKLVNLALGYAQTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATE 64
+ +QE K+V+ +A F +W G + + D + S
Sbjct: 59 LEIQETGSLDKVVS----WAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDV 114
Query: 65 YRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKL--KSEV 122
Y FF W+G GLL+ GPKW HRK++ P FH ++LK +V +F +++ +++K K+
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 123 GKTFDVHDYMSGTTVDILLETAMGISRKTQDES-GFDYAMAVMKMCDIIHQRHYKFWMRS 181
GK+FD+ + ++ L++ G S Y +AV + ++ QR F +
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHN 234
Query: 182 EIVFKLTSFFKQQTKLLGIIHGLTNKVIKNKKETYLENKAK 222
+ ++ LT ++ + + H T++VI+ +K + K +
Sbjct: 235 DFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVR 275
>AY151049-1|AAN72312.1| 497|Homo sapiens pulmonary cytochrome P450
4B1 variant protein.
Length = 497
Score = 155 bits (376), Expect = 3e-37
Identities = 79/231 (34%), Positives = 129/231 (55%), Gaps = 3/231 (1%)
Query: 267 VGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQD 326
+ ++ L FLD+++ + K+SD +++ EVDT MFEGHDTT +G S+ L + ++ +
Sbjct: 263 IQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPE 322
Query: 327 VQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTIST 386
Q R +E+ +I GD D + D +M YL I ES RLYPPVP + R+L++ VT
Sbjct: 323 HQHRCREEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF-V 380
Query: 387 KNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV 446
+PAG+ + + + LHR + DPEVF+ F EN RH ++++PFSAGPR+C+
Sbjct: 381 DGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCI 440
Query: 447 GRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
G+++A F + K+ ++L+ GF + ++P
Sbjct: 441 GQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMP-QLVLRSKNGFHLHLKP 490
Score = 80.2 bits (189), Expect = 2e-14
Identities = 41/153 (26%), Positives = 80/153 (52%), Gaps = 3/153 (1%)
Query: 73 GEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKL--KSEVGKTFDVHD 130
G GLL+ GPKW HRK++ P FH ++LK +V +F +++ +++K K+ GK+FD+
Sbjct: 108 GRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFC 167
Query: 131 YMSGTTVDILLETAMGISRKTQDES-GFDYAMAVMKMCDIIHQRHYKFWMRSEIVFKLTS 189
+ ++ L++ G S Y +AV + ++ QR F ++ ++ LT
Sbjct: 168 DVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTP 227
Query: 190 FFKQQTKLLGIIHGLTNKVIKNKKETYLENKAK 222
++ + + H T++VI+ +K + K +
Sbjct: 228 HGRRFLRACQVAHDHTDQVIRERKAALQDEKVR 260
>AY151048-1|AAN72311.1| 512|Homo sapiens pulmonary cytochrome P450
4B1 protein.
Length = 512
Score = 155 bits (376), Expect = 3e-37
Identities = 79/231 (34%), Positives = 129/231 (55%), Gaps = 3/231 (1%)
Query: 267 VGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQD 326
+ ++ L FLD+++ + K+SD +++ EVDT MFEGHDTT +G S+ L + ++ +
Sbjct: 278 IQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPE 337
Query: 327 VQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTIST 386
Q R +E+ +I GD D + D +M YL I ES RLYPPVP + R+L++ VT
Sbjct: 338 HQHRCREEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF-V 395
Query: 387 KNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV 446
+PAG+ + + + LHR + DPEVF+ F EN RH ++++PFSAGPR+C+
Sbjct: 396 DGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCI 455
Query: 447 GRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
G+++A F + K+ ++L+ GF + ++P
Sbjct: 456 GQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMP-QLVLRSKNGFHLHLKP 505
Score = 92.7 bits (220), Expect = 3e-18
Identities = 55/221 (24%), Positives = 104/221 (47%), Gaps = 7/221 (3%)
Query: 5 IHVQEENLTQKLVNLALGYAQTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATE 64
+ +QE K+V+ +A F +W G + + D + S
Sbjct: 59 LEIQETGSLDKVVS----WAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDV 114
Query: 65 YRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKL--KSEV 122
Y FF W+G GLL+ GPKW HRK++ P FH ++LK +V +F +++ +++K K+
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 123 GKTFDVHDYMSGTTVDILLETAMGISRKTQDES-GFDYAMAVMKMCDIIHQRHYKFWMRS 181
GK+FD+ + ++ L++ G S Y +AV + ++ QR F +
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHN 234
Query: 182 EIVFKLTSFFKQQTKLLGIIHGLTNKVIKNKKETYLENKAK 222
+ ++ LT ++ + + H T++VI+ +K + K +
Sbjct: 235 DFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVR 275
>AY064485-1|AAL57720.1| 511|Homo sapiens cytochrome P450 protein.
Length = 511
Score = 155 bits (376), Expect = 3e-37
Identities = 79/231 (34%), Positives = 129/231 (55%), Gaps = 3/231 (1%)
Query: 267 VGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQD 326
+ ++ L FLD+++ + K+SD +++ EVDT MFEGHDTT +G S+ L + ++ +
Sbjct: 277 IQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPE 336
Query: 327 VQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTIST 386
Q R +E+ +I GD D + D +M YL I ES RLYPPVP + R+L++ VT
Sbjct: 337 HQHRCREEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF-V 394
Query: 387 KNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV 446
+PAG+ + + + LHR + DPEVF+ F EN RH ++++PFSAGPR+C+
Sbjct: 395 DGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCI 454
Query: 447 GRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
G+++A F + K+ ++L+ GF + ++P
Sbjct: 455 GQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMP-QLVLRSKNGFHLHLKP 504
Score = 94.3 bits (224), Expect = 9e-19
Identities = 53/220 (24%), Positives = 103/220 (46%), Gaps = 6/220 (2%)
Query: 5 IHVQEENLTQKLVNLALGYAQTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATE 64
+ +QE K+V+ +A F +W G + + D + S
Sbjct: 59 LEIQETGSLDKVVS----WAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDV 114
Query: 65 YRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEV-- 122
Y FF W+G GLL+ GPKW HRK++ P FH ++LK +V +F +++ +++K + +
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAWE 174
Query: 123 GKTFDVHDYMSGTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSE 182
GK+FD+ + ++ L++ G Y +AV + ++ QR F ++
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHND 234
Query: 183 IVFKLTSFFKQQTKLLGIIHGLTNKVIKNKKETYLENKAK 222
++ LT ++ + + H T++VI+ +K + K +
Sbjct: 235 FIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVR 274
>AL593856-7|CAI16983.1| 497|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 497
Score = 155 bits (376), Expect = 3e-37
Identities = 79/231 (34%), Positives = 129/231 (55%), Gaps = 3/231 (1%)
Query: 267 VGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQD 326
+ ++ L FLD+++ + K+SD +++ EVDT MFEGHDTT +G S+ L + ++ +
Sbjct: 263 IQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPE 322
Query: 327 VQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTIST 386
Q R +E+ +I GD D + D +M YL I ES RLYPPVP + R+L++ VT
Sbjct: 323 HQHRCREEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF-V 380
Query: 387 KNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV 446
+PAG+ + + + LHR + DPEVF+ F EN RH ++++PFSAGPR+C+
Sbjct: 381 DGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCI 440
Query: 447 GRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
G+++A F + K+ ++L+ GF + ++P
Sbjct: 441 GQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMP-QLVLRSKNGFHLHLKP 490
Score = 80.2 bits (189), Expect = 2e-14
Identities = 41/153 (26%), Positives = 80/153 (52%), Gaps = 3/153 (1%)
Query: 73 GEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKL--KSEVGKTFDVHD 130
G GLL+ GPKW HRK++ P FH ++LK +V +F +++ +++K K+ GK+FD+
Sbjct: 108 GRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFC 167
Query: 131 YMSGTTVDILLETAMGISRKTQDES-GFDYAMAVMKMCDIIHQRHYKFWMRSEIVFKLTS 189
+ ++ L++ G S Y +AV + ++ QR F ++ ++ LT
Sbjct: 168 DVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTP 227
Query: 190 FFKQQTKLLGIIHGLTNKVIKNKKETYLENKAK 222
++ + + H T++VI+ +K + K +
Sbjct: 228 HGRRFLRACQVAHDHTDQVIRERKAALQDEKVR 260
>AL593856-6|CAI16982.1| 512|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 512
Score = 155 bits (376), Expect = 3e-37
Identities = 79/231 (34%), Positives = 129/231 (55%), Gaps = 3/231 (1%)
Query: 267 VGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQD 326
+ ++ L FLD+++ + K+SD +++ EVDT MFEGHDTT +G S+ L + ++ +
Sbjct: 278 IQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPE 337
Query: 327 VQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTIST 386
Q R +E+ +I GD D + D +M YL I ES RLYPPVP + R+L++ VT
Sbjct: 338 HQHRCREEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF-V 395
Query: 387 KNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV 446
+PAG+ + + + LHR + DPEVF+ F EN RH ++++PFSAGPR+C+
Sbjct: 396 DGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCI 455
Query: 447 GRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
G+++A F + K+ ++L+ GF + ++P
Sbjct: 456 GQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMP-QLVLRSKNGFHLHLKP 505
Score = 92.7 bits (220), Expect = 3e-18
Identities = 55/221 (24%), Positives = 104/221 (47%), Gaps = 7/221 (3%)
Query: 5 IHVQEENLTQKLVNLALGYAQTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATE 64
+ +QE K+V+ +A F +W G + + D + S
Sbjct: 59 LEIQETGSLDKVVS----WAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDV 114
Query: 65 YRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKL--KSEV 122
Y FF W+G GLL+ GPKW HRK++ P FH ++LK +V +F +++ +++K K+
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 123 GKTFDVHDYMSGTTVDILLETAMGISRKTQDES-GFDYAMAVMKMCDIIHQRHYKFWMRS 181
GK+FD+ + ++ L++ G S Y +AV + ++ QR F +
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHN 234
Query: 182 EIVFKLTSFFKQQTKLLGIIHGLTNKVIKNKKETYLENKAK 222
+ ++ LT ++ + + H T++VI+ +K + K +
Sbjct: 235 DFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVR 275
>AL593856-5|CAI16981.1| 511|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 511
Score = 155 bits (376), Expect = 3e-37
Identities = 79/231 (34%), Positives = 129/231 (55%), Gaps = 3/231 (1%)
Query: 267 VGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQD 326
+ ++ L FLD+++ + K+SD +++ EVDT MFEGHDTT +G S+ L + ++ +
Sbjct: 277 IQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPE 336
Query: 327 VQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTIST 386
Q R +E+ +I GD D + D +M YL I ES RLYPPVP + R+L++ VT
Sbjct: 337 HQHRCREEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF-V 394
Query: 387 KNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV 446
+PAG+ + + + LHR + DPEVF+ F EN RH ++++PFSAGPR+C+
Sbjct: 395 DGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCI 454
Query: 447 GRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
G+++A F + K+ ++L+ GF + ++P
Sbjct: 455 GQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMP-QLVLRSKNGFHLHLKP 504
Score = 95.1 bits (226), Expect = 5e-19
Identities = 54/220 (24%), Positives = 103/220 (46%), Gaps = 6/220 (2%)
Query: 5 IHVQEENLTQKLVNLALGYAQTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATE 64
+ +QE K+V+ +A F +W G + + D + S
Sbjct: 59 LEIQETGSLDKVVS----WAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDV 114
Query: 65 YRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKL--KSEV 122
Y FF W+G GLL+ GPKW HRK++ P FH ++LK +V +F +++ +++K K+
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 123 GKTFDVHDYMSGTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSE 182
GK+FD+ + ++ L++ G Y +AV + ++ QR F ++
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHND 234
Query: 183 IVFKLTSFFKQQTKLLGIIHGLTNKVIKNKKETYLENKAK 222
++ LT ++ + + H T++VI+ +K + K +
Sbjct: 235 FIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVR 274
>AL356793-4|CAI22559.1| 511|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 511
Score = 155 bits (376), Expect = 3e-37
Identities = 79/231 (34%), Positives = 129/231 (55%), Gaps = 3/231 (1%)
Query: 267 VGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQD 326
+ ++ L FLD+++ + K+SD +++ EVDT MFEGHDTT +G S+ L + ++ +
Sbjct: 277 IQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPE 336
Query: 327 VQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTIST 386
Q R +E+ +I GD D + D +M YL I ES RLYPPVP + R+L++ VT
Sbjct: 337 HQHRCREEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF-V 394
Query: 387 KNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV 446
+PAG+ + + + LHR + DPEVF+ F EN RH ++++PFSAGPR+C+
Sbjct: 395 DGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCI 454
Query: 447 GRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
G+++A F + K+ ++L+ GF + ++P
Sbjct: 455 GQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMP-QLVLRSKNGFHLHLKP 504
Score = 95.1 bits (226), Expect = 5e-19
Identities = 54/220 (24%), Positives = 103/220 (46%), Gaps = 6/220 (2%)
Query: 5 IHVQEENLTQKLVNLALGYAQTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATE 64
+ +QE K+V+ +A F +W G + + D + S
Sbjct: 59 LEIQETGSLDKVVS----WAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDV 114
Query: 65 YRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKL--KSEV 122
Y FF W+G GLL+ GPKW HRK++ P FH ++LK +V +F +++ +++K K+
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 123 GKTFDVHDYMSGTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSE 182
GK+FD+ + ++ L++ G Y +AV + ++ QR F ++
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHND 234
Query: 183 IVFKLTSFFKQQTKLLGIIHGLTNKVIKNKKETYLENKAK 222
++ LT ++ + + H T++VI+ +K + K +
Sbjct: 235 FIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVR 274
>AL356793-3|CAI22557.1| 512|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 512
Score = 155 bits (376), Expect = 3e-37
Identities = 79/231 (34%), Positives = 129/231 (55%), Gaps = 3/231 (1%)
Query: 267 VGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQD 326
+ ++ L FLD+++ + K+SD +++ EVDT MFEGHDTT +G S+ L + ++ +
Sbjct: 278 IQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPE 337
Query: 327 VQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTIST 386
Q R +E+ +I GD D + D +M YL I ES RLYPPVP + R+L++ VT
Sbjct: 338 HQHRCREEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF-V 395
Query: 387 KNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV 446
+PAG+ + + + LHR + DPEVF+ F EN RH ++++PFSAGPR+C+
Sbjct: 396 DGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCI 455
Query: 447 GRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
G+++A F + K+ ++L+ GF + ++P
Sbjct: 456 GQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMP-QLVLRSKNGFHLHLKP 505
Score = 92.7 bits (220), Expect = 3e-18
Identities = 55/221 (24%), Positives = 104/221 (47%), Gaps = 7/221 (3%)
Query: 5 IHVQEENLTQKLVNLALGYAQTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATE 64
+ +QE K+V+ +A F +W G + + D + S
Sbjct: 59 LEIQETGSLDKVVS----WAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDV 114
Query: 65 YRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKL--KSEV 122
Y FF W+G GLL+ GPKW HRK++ P FH ++LK +V +F +++ +++K K+
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 123 GKTFDVHDYMSGTTVDILLETAMGISRKTQDES-GFDYAMAVMKMCDIIHQRHYKFWMRS 181
GK+FD+ + ++ L++ G S Y +AV + ++ QR F +
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHN 234
Query: 182 EIVFKLTSFFKQQTKLLGIIHGLTNKVIKNKKETYLENKAK 222
+ ++ LT ++ + + H T++VI+ +K + K +
Sbjct: 235 DFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVR 275
>AL356793-2|CAI22558.1| 497|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 497
Score = 155 bits (376), Expect = 3e-37
Identities = 79/231 (34%), Positives = 129/231 (55%), Gaps = 3/231 (1%)
Query: 267 VGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQD 326
+ ++ L FLD+++ + K+SD +++ EVDT MFEGHDTT +G S+ L + ++ +
Sbjct: 263 IQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPE 322
Query: 327 VQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTIST 386
Q R +E+ +I GD D + D +M YL I ES RLYPPVP + R+L++ VT
Sbjct: 323 HQHRCREEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF-V 380
Query: 387 KNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV 446
+PAG+ + + + LHR + DPEVF+ F EN RH ++++PFSAGPR+C+
Sbjct: 381 DGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCI 440
Query: 447 GRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
G+++A F + K+ ++L+ GF + ++P
Sbjct: 441 GQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMP-QLVLRSKNGFHLHLKP 490
Score = 80.2 bits (189), Expect = 2e-14
Identities = 41/153 (26%), Positives = 80/153 (52%), Gaps = 3/153 (1%)
Query: 73 GEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKL--KSEVGKTFDVHD 130
G GLL+ GPKW HRK++ P FH ++LK +V +F +++ +++K K+ GK+FD+
Sbjct: 108 GRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFC 167
Query: 131 YMSGTTVDILLETAMGISRKTQDES-GFDYAMAVMKMCDIIHQRHYKFWMRSEIVFKLTS 189
+ ++ L++ G S Y +AV + ++ QR F ++ ++ LT
Sbjct: 168 DVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTP 227
Query: 190 FFKQQTKLLGIIHGLTNKVIKNKKETYLENKAK 222
++ + + H T++VI+ +K + K +
Sbjct: 228 HGRRFLRACQVAHDHTDQVIRERKAALQDEKVR 260
>AF491285-1|AAM09532.1| 511|Homo sapiens cytochrome P450 protein.
Length = 511
Score = 155 bits (376), Expect = 3e-37
Identities = 79/231 (34%), Positives = 129/231 (55%), Gaps = 3/231 (1%)
Query: 267 VGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQD 326
+ ++ L FLD+++ + K+SD +++ EVDT MFEGHDTT +G S+ L + ++ +
Sbjct: 277 IQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCIALYPE 336
Query: 327 VQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTIST 386
Q R +E+ +I GD D + D +M YL I ES RLYPPVP + R+L++ VT
Sbjct: 337 HQHRCREEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF-V 394
Query: 387 KNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV 446
+PAG+ + + + LHR + DPEVF+ F EN RH ++++PFSAGPR+C+
Sbjct: 395 DGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCI 454
Query: 447 GRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
G+++A F + K+ ++L+ GF + ++P
Sbjct: 455 GQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMP-QLVLRSKNGFHLHLKP 504
Score = 95.1 bits (226), Expect = 5e-19
Identities = 54/220 (24%), Positives = 103/220 (46%), Gaps = 6/220 (2%)
Query: 5 IHVQEENLTQKLVNLALGYAQTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATE 64
+ +QE K+V+ +A F +W G + + D + S
Sbjct: 59 LEIQETGSLDKVVS----WAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDV 114
Query: 65 YRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKL--KSEV 122
Y FF W+G GLL+ GPKW HRK++ P FH ++LK +V +F +++ +++K K+
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 123 GKTFDVHDYMSGTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSE 182
GK+FD+ + ++ L++ G Y +AV + ++ QR F ++
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHND 234
Query: 183 IVFKLTSFFKQQTKLLGIIHGLTNKVIKNKKETYLENKAK 222
++ LT ++ + + H T++VI+ +K + K +
Sbjct: 235 FIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVR 274
>AY064486-1|AAL57721.1| 511|Homo sapiens cytochrome P450 protein.
Length = 511
Score = 155 bits (375), Expect = 5e-37
Identities = 79/231 (34%), Positives = 128/231 (55%), Gaps = 3/231 (1%)
Query: 267 VGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQD 326
+ ++ L FLD+++ + K+SD +++ EVDT MFEGHDTT G S+ L + ++ +
Sbjct: 277 IQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTGGISWFLYCMALYPE 336
Query: 327 VQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTIST 386
Q R +E+ +I GD D + D +M YL I ES RLYPPVP + R+L++ VT
Sbjct: 337 HQHRCREEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF-V 394
Query: 387 KNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV 446
+PAG+ + + + LHR + DPEVF+ F EN RH ++++PFSAGPR+C+
Sbjct: 395 DGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCI 454
Query: 447 GRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
G+++A F + K+ ++L+ GF + ++P
Sbjct: 455 GQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMP-QLVLRSKNGFHLHLKP 504
Score = 95.1 bits (226), Expect = 5e-19
Identities = 54/220 (24%), Positives = 103/220 (46%), Gaps = 6/220 (2%)
Query: 5 IHVQEENLTQKLVNLALGYAQTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATE 64
+ +QE K+V+ +A F +W G + + D + S
Sbjct: 59 LEIQETGSLDKVVS----WAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDV 114
Query: 65 YRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKL--KSEV 122
Y FF W+G GLL+ GPKW HRK++ P FH ++LK +V +F +++ +++K K+
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 123 GKTFDVHDYMSGTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSE 182
GK+FD+ + ++ L++ G Y +AV + ++ QR F ++
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHND 234
Query: 183 IVFKLTSFFKQQTKLLGIIHGLTNKVIKNKKETYLENKAK 222
++ LT ++ + + H T++VI+ +K + K +
Sbjct: 235 FIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVR 274
>BC016853-1|AAH16853.1| 524|Homo sapiens CYP4F11 protein protein.
Length = 524
Score = 151 bits (366), Expect = 6e-36
Identities = 82/230 (35%), Positives = 126/230 (54%), Gaps = 4/230 (1%)
Query: 269 EKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQ 328
+ K L F+D+++ S ++SD +I+ E DT MFEGHDTTA+G S+VL L H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351
Query: 329 ARVYDELYQIFGDSDR-PATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTK 387
+ E+ ++ D + + D ++ +L I ESLRL+PPVPVI+R +D +
Sbjct: 352 EQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDG 411
Query: 388 NYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVG 447
VIP G +I +H P + DPEV++P F EN + R ++IPFSAGPR+C+G
Sbjct: 412 R-VIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFNQENIKERSPLAFIPFSAGPRNCIG 470
Query: 448 RKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
+ +A +FR + E K ++IL+ G ++VEP
Sbjct: 471 QAFAMAEMKVVLALTLLHFRILPTHTEPRRK--PELILRAEGGLWLRVEP 518
Score = 106 bits (255), Expect = 2e-22
Identities = 67/228 (29%), Positives = 119/228 (52%), Gaps = 20/228 (8%)
Query: 9 EENLTQKLVNLALGYAQTFGNVIRVWLGSKL-IVFLVDADDIEIILNSHVHIDKATE--Y 65
EE + + L L Y Q F ++WLG ++ L D I I ++ + Y
Sbjct: 71 EEGM-KTLTQLVTTYPQGF----KLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFY 125
Query: 66 RFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEK---LKSEV 122
F KPWLG+GLL+S G KW HR+M+ P FH NILK ++ IFN++ N + +K L SE
Sbjct: 126 GFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEG 185
Query: 123 GKTFDVHDYMSGTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSE 182
D+ +++S T+D L + Q++ +Y A++++ + +R+ + + ++
Sbjct: 186 SARLDMFEHISLMTLDSLQKCVFSFESNCQEKPS-EYIAAILELSAFVEKRNQQILLHTD 244
Query: 183 IVFKLTSFFKQQTKLLGIIHGLTNKVIKNKKET--------YLENKAK 222
++ LT ++ + ++H T+ VI+ ++ T +L+NKAK
Sbjct: 245 FLYYLTPDGQRFRRACHLVHDFTDAVIQERRRTLPTQGIDDFLKNKAK 292
>AF236085-1|AAG15889.1| 524|Homo sapiens CYP4F11 protein.
Length = 524
Score = 150 bits (364), Expect = 1e-35
Identities = 82/230 (35%), Positives = 126/230 (54%), Gaps = 4/230 (1%)
Query: 269 EKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQ 328
+ K L F+D+++ S ++SD +I+ E DT MFEGHDTTA+G S+VL L H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351
Query: 329 ARVYDELYQIFGDSDR-PATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTK 387
+ E+ ++ D + + D ++ +L I ESLRL+PPVPVI+R +D +
Sbjct: 352 EQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDG 411
Query: 388 NYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVG 447
VIP G +I +H P + DPEV++P F EN + R ++IPFSAGPR+C+G
Sbjct: 412 R-VIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFNQENIKERSPLAFIPFSAGPRNCIG 470
Query: 448 RKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
+ +A +FR + E K ++IL+ G ++VEP
Sbjct: 471 QAFAMAEMKVVLALTLLHFRILPTHIEPRRK--PELILRAEGGLWLRVEP 518
Score = 106 bits (255), Expect = 2e-22
Identities = 67/228 (29%), Positives = 119/228 (52%), Gaps = 20/228 (8%)
Query: 9 EENLTQKLVNLALGYAQTFGNVIRVWLGSKL-IVFLVDADDIEIILNSHVHIDKATE--Y 65
EE + + L L Y Q F ++WLG ++ L D I I ++ + Y
Sbjct: 71 EEGM-KTLTQLVTTYPQGF----KLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFY 125
Query: 66 RFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEK---LKSEV 122
F KPWLG+GLL+S G KW HR+M+ P FH NILK ++ IFN++ N + +K L SE
Sbjct: 126 GFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEG 185
Query: 123 GKTFDVHDYMSGTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSE 182
D+ +++S T+D L + Q++ +Y A++++ + +R+ + + ++
Sbjct: 186 SARLDMFEHISLMTLDSLQKCVFSFESNCQEKPS-EYIAAILELSAFVEKRNQQILLHTD 244
Query: 183 IVFKLTSFFKQQTKLLGIIHGLTNKVIKNKKET--------YLENKAK 222
++ LT ++ + ++H T+ VI+ ++ T +L+NKAK
Sbjct: 245 FLYYLTPDGQRFRRACHLVHDFTDAVIQERRRTLPTQGIDDFLKNKAK 292
>S67580-1|AAB29502.1| 519|Homo sapiens fatty acid omega-hydroxylase
protein.
Length = 519
Score = 148 bits (358), Expect = 5e-35
Identities = 76/229 (33%), Positives = 124/229 (54%), Gaps = 5/229 (2%)
Query: 267 VGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQD 326
+ K+ L FLD+++ + + +SD +++ EVDT MFEGHDTTA+G S++L L H
Sbjct: 283 IKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPK 342
Query: 327 VQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTIST 386
Q R +E++ + GD T+ +M Y I E+LRLYPPVP I R+L+ VT
Sbjct: 343 HQERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTF-P 400
Query: 387 KNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV 446
+P G V++ + LH PK + +PEVF+P F P + Q H ++++PFS G R+C+
Sbjct: 401 DGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPSRFAPGSAQ--HSHAFLPFSGGSRNCI 458
Query: 447 GRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKV 495
G+++A F + + + ++LK G +++
Sbjct: 459 GKQFAMNELKVATALTLLRFELLPDPTRIPIPI-ARLVLKSKNGIHLRL 506
Score = 97.9 bits (233), Expect = 7e-20
Identities = 59/212 (27%), Positives = 111/212 (52%), Gaps = 6/212 (2%)
Query: 6 HVQEENLTQKLVNLALGYAQTFGNVIRVWL-GSKLIVFLVDADDIEIILNSHVHIDKATE 64
H+QE Q+L + + +TF + WL G K+ V L D D +++IL +
Sbjct: 62 HIQELQQDQELQRIQK-WVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGS- 119
Query: 65 YRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGK 124
YRF PW+G GLL+ +G W HR+M+ P FH +ILK +VG+ + +++K + +G+
Sbjct: 120 YRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQ 179
Query: 125 --TFDVHDYMSGTTVDILLETAMGISRKTQ-DESGFDYAMAVMKMCDIIHQRHYKFWMRS 181
+V ++S T+D +++ A Q D + Y A+ + +++ R + ++
Sbjct: 180 DSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQN 239
Query: 182 EIVFKLTSFFKQQTKLLGIIHGLTNKVIKNKK 213
+ ++ LTS + + + H T++VI+ +K
Sbjct: 240 DTIYSLTSAGRWTHRACQLAHQHTDQVIQLRK 271
>AY280371-1|AAQ21367.1| 519|Homo sapiens cytochrome P450 4A22K
protein.
Length = 519
Score = 148 bits (358), Expect = 5e-35
Identities = 77/229 (33%), Positives = 125/229 (54%), Gaps = 5/229 (2%)
Query: 267 VGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQD 326
+ K+ L FLD+++ + + +SD +++ EVDT MFEGHDTTA+G S++L L H
Sbjct: 283 IKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPK 342
Query: 327 VQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTIST 386
Q R +E++ + GD T+ +M Y I E+LRLYPPVP I R+L+ VT
Sbjct: 343 HQERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTF-P 400
Query: 387 KNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV 446
+P G V++ + LH PK + +PEVF+P F P + Q H ++++PFS G R+C+
Sbjct: 401 DGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQ--HSHAFLPFSGGSRNCI 458
Query: 447 GRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKV 495
G+++A F + + P + ++LK G +++
Sbjct: 459 GKQFAMNQLKVARALTLLRFELLPD-PTRTPIPMARLVLKSKNGIHLRL 506
Score = 90.6 bits (215), Expect = 1e-17
Identities = 55/212 (25%), Positives = 109/212 (51%), Gaps = 6/212 (2%)
Query: 6 HVQEENLTQKLVNLALGYAQTFGNVIRVWL-GSKLIVFLVDADDIEIILNSHVHIDKATE 64
H+QE Q+L + +TF + W+ G K+ V L D D +++IL +
Sbjct: 62 HIQEFQHDQELQRIQ-ERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGS- 119
Query: 65 YRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGK 124
Y+F PW+G LL+ +G W HR+M+ P FH +ILK +VG+ + +++K + +G+
Sbjct: 120 YKFLAPWIGYSLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQ 179
Query: 125 --TFDVHDYMSGTTVDILLETAMGISRKTQ-DESGFDYAMAVMKMCDIIHQRHYKFWMRS 181
+ ++S T+D ++++A Q D + Y A+ + +++ R + ++
Sbjct: 180 DSPLEFFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQN 239
Query: 182 EIVFKLTSFFKQQTKLLGIIHGLTNKVIKNKK 213
+ ++ LTS + + + H T++VI+ +K
Sbjct: 240 DTIYSLTSAGRWTHRACQLAHQHTDQVIQLRK 271
>S67581-1|AAB29503.1| 591|Homo sapiens fatty acid omega-hydroxylase
protein.
Length = 591
Score = 147 bits (357), Expect = 7e-35
Identities = 72/185 (38%), Positives = 112/185 (60%), Gaps = 4/185 (2%)
Query: 267 VGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQD 326
+ K+ L FLD+++ + + +SD +++ EVDT MFEGHDTTA+G S++L L H
Sbjct: 283 IKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPK 342
Query: 327 VQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTIST 386
Q R +E++ + GD T+ +M Y I E+LRLYPPVP I R+L+ VT
Sbjct: 343 HQERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTF-P 400
Query: 387 KNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV 446
+P G V++ + LH PK + +PEVF+P F P + Q H ++++PFS G R+C+
Sbjct: 401 DGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPSRFAPGSAQ--HSHAFLPFSGGSRNCI 458
Query: 447 GRKYA 451
G+++A
Sbjct: 459 GKQFA 463
Score = 97.9 bits (233), Expect = 7e-20
Identities = 59/212 (27%), Positives = 111/212 (52%), Gaps = 6/212 (2%)
Query: 6 HVQEENLTQKLVNLALGYAQTFGNVIRVWL-GSKLIVFLVDADDIEIILNSHVHIDKATE 64
H+QE Q+L + + +TF + WL G K+ V L D D +++IL +
Sbjct: 62 HIQELQQDQELQRIQK-WVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGS- 119
Query: 65 YRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGK 124
YRF PW+G GLL+ +G W HR+M+ P FH +ILK +VG+ + +++K + +G+
Sbjct: 120 YRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQ 179
Query: 125 --TFDVHDYMSGTTVDILLETAMGISRKTQ-DESGFDYAMAVMKMCDIIHQRHYKFWMRS 181
+V ++S T+D +++ A Q D + Y A+ + +++ R + ++
Sbjct: 180 DSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQN 239
Query: 182 EIVFKLTSFFKQQTKLLGIIHGLTNKVIKNKK 213
+ ++ LTS + + + H T++VI+ +K
Sbjct: 240 DTIYSLTSAGRWTHRACQLAHQHTDQVIQLRK 271
>AY358631-1|AAQ88994.1| 505|Homo sapiens EPSW3060 protein.
Length = 505
Score = 147 bits (357), Expect = 7e-35
Identities = 74/204 (36%), Positives = 119/204 (58%), Gaps = 2/204 (0%)
Query: 248 SDTVFKGYRDDLDFNDENDVGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGH 307
++ V + ++ L + D +K+R FLD+++ + T S+ +++ EV T MF GH
Sbjct: 257 TEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSENTKDFSEADLQAEVKTFMFAGH 316
Query: 308 DTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRL 367
DTT++ S++L L + + Q R DE+ ++ GD T+ +M Y I E LRL
Sbjct: 317 DTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSS-ITWEHLSQMPYTTMCIKECLRL 375
Query: 368 YPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENT 427
Y PV I+R L++ +T +PAG TV I + LH P +++DP+VFNP F EN+
Sbjct: 376 YAPVVNISRLLDKPITFPDGRS-LPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENS 434
Query: 428 QNRHYYSYIPFSAGPRSCVGRKYA 451
+ H Y++IPFSAG R+C+G+ +A
Sbjct: 435 EKIHPYAFIPFSAGLRNCIGQHFA 458
Score = 93.5 bits (222), Expect = 2e-18
Identities = 54/195 (27%), Positives = 103/195 (52%), Gaps = 4/195 (2%)
Query: 31 IRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKPWLGEGLLISSGPKWRSHRKM 90
+ +W+G + F V D IL A ++ + W+G GL+ G KW+ HR++
Sbjct: 80 VPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILESWVGRGLVTLDGSKWKKHRQI 139
Query: 91 IAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGKT--FDVHDYMSGTTVDILLETAMGIS 148
+ P F+I+ILK F+ + +++ ++ K + + + ++ ++S T+D +++ A
Sbjct: 140 VKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSHQ 199
Query: 149 RKTQDESGFD-YAMAVMKMCDIIHQRHYKFWMRSEIVFKLTSFFKQQTKLLGIIHGLTNK 207
Q +S D Y AV + I +QR F +++VFK +S + +K +H T K
Sbjct: 200 GSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFTEK 259
Query: 208 VIKNKKETYLENKAK 222
VI+++KE+ L++K K
Sbjct: 260 VIQDRKES-LKDKLK 273
>AY280372-1|AAQ21368.1| 519|Homo sapiens cytochrome P450 4A22
protein.
Length = 519
Score = 147 bits (357), Expect = 7e-35
Identities = 77/229 (33%), Positives = 125/229 (54%), Gaps = 5/229 (2%)
Query: 267 VGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQD 326
+ K+ L FLD+++ + + +SD +++ EVDT MFEGHDTTA+G S++L L H
Sbjct: 283 IKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPK 342
Query: 327 VQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTIST 386
Q R +E++ + GD T+ +M Y I E+LRLYPPVP I R+L+ VT
Sbjct: 343 HQERCREEIHGLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTF-P 400
Query: 387 KNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV 446
+P G V++ + LH PK + +PEVF+P F P + Q H ++++PFS G R+C+
Sbjct: 401 DGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPSRFAPGSAQ--HSHAFLPFSGGSRNCI 458
Query: 447 GRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKV 495
G+++A F + + P + ++LK G +++
Sbjct: 459 GKQFAMNQLKVARALTLLRFELLPD-PTRIPIPMARLVLKSKNGIHLRL 506
Score = 90.2 bits (214), Expect = 1e-17
Identities = 55/212 (25%), Positives = 107/212 (50%), Gaps = 6/212 (2%)
Query: 6 HVQEENLTQKLVNLALGYAQTFGNVIRVWL-GSKLIVFLVDADDIEIILNSHVHIDKATE 64
H+QE Q+L + +TF + W+ G K+ V L D D +++IL +
Sbjct: 62 HIQEFQHDQELQRIQ-ERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDSKSHGS- 119
Query: 65 YRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGK 124
Y+F PW+G LL+ +G W HR+M+ P FH +ILK +VG+ + +++K + +G+
Sbjct: 120 YKFLAPWIGYSLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQ 179
Query: 125 --TFDVHDYMSGTTVDILLETAMGISRKTQ-DESGFDYAMAVMKMCDIIHQRHYKFWMRS 181
+ ++S T+D ++++A Q D + Y A+ + ++ R + +
Sbjct: 180 DSPLEFFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLSSLVFCRMRNAFHEN 239
Query: 182 EIVFKLTSFFKQQTKLLGIIHGLTNKVIKNKK 213
+ ++ LTS + + + H T++VI+ +K
Sbjct: 240 DAIYSLTSAGRWTHRACQLAHQHTDQVIQLRK 271
>AY262056-1|AAO89257.1| 505|Homo sapiens cytochrome P450 protein.
Length = 505
Score = 147 bits (357), Expect = 7e-35
Identities = 74/204 (36%), Positives = 119/204 (58%), Gaps = 2/204 (0%)
Query: 248 SDTVFKGYRDDLDFNDENDVGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGH 307
++ V + ++ L + D +K+R FLD+++ + T S+ +++ EV T MF GH
Sbjct: 257 TEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSENTKDFSEADLQAEVKTFMFAGH 316
Query: 308 DTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRL 367
DTT++ S++L L + + Q R DE+ ++ GD T+ +M Y I E LRL
Sbjct: 317 DTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSS-ITWEHLSQMPYTTMCIKECLRL 375
Query: 368 YPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENT 427
Y PV I+R L++ +T +PAG TV I + LH P +++DP+VFNP F EN+
Sbjct: 376 YAPVVNISRLLDKPITFPDGRS-LPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENS 434
Query: 428 QNRHYYSYIPFSAGPRSCVGRKYA 451
+ H Y++IPFSAG R+C+G+ +A
Sbjct: 435 EKIHPYAFIPFSAGLRNCIGQHFA 458
Score = 93.5 bits (222), Expect = 2e-18
Identities = 54/195 (27%), Positives = 103/195 (52%), Gaps = 4/195 (2%)
Query: 31 IRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKPWLGEGLLISSGPKWRSHRKM 90
+ +W+G + F V D IL A ++ + W+G GL+ G KW+ HR++
Sbjct: 80 VPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILESWVGRGLVTLDGSKWKKHRQI 139
Query: 91 IAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGKT--FDVHDYMSGTTVDILLETAMGIS 148
+ P F+I+ILK F+ + +++ ++ K + + + ++ ++S T+D +++ A
Sbjct: 140 VKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSHQ 199
Query: 149 RKTQDESGFD-YAMAVMKMCDIIHQRHYKFWMRSEIVFKLTSFFKQQTKLLGIIHGLTNK 207
Q +S D Y AV + I +QR F +++VFK +S + +K +H T K
Sbjct: 200 GSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFTEK 259
Query: 208 VIKNKKETYLENKAK 222
VI+++KE+ L++K K
Sbjct: 260 VIQDRKES-LKDKLK 273
>AL450996-2|CAH71036.1| 505|Homo sapiens cytochrome P450, family 4,
subfamily Z, polypeptide 1 protein.
Length = 505
Score = 147 bits (357), Expect = 7e-35
Identities = 74/204 (36%), Positives = 119/204 (58%), Gaps = 2/204 (0%)
Query: 248 SDTVFKGYRDDLDFNDENDVGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGH 307
++ V + ++ L + D +K+R FLD+++ + T S+ +++ EV T MF GH
Sbjct: 257 TEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSENTKDFSEADLQAEVKTFMFAGH 316
Query: 308 DTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRL 367
DTT++ S++L L + + Q R DE+ ++ GD T+ +M Y I E LRL
Sbjct: 317 DTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSS-ITWEHLSQMPYTTMCIKECLRL 375
Query: 368 YPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENT 427
Y PV I+R L++ +T +PAG TV I + LH P +++DP+VFNP F EN+
Sbjct: 376 YAPVVNISRLLDKPITFPDGRS-LPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENS 434
Query: 428 QNRHYYSYIPFSAGPRSCVGRKYA 451
+ H Y++IPFSAG R+C+G+ +A
Sbjct: 435 EKIHPYAFIPFSAGLRNCIGQHFA 458
Score = 93.5 bits (222), Expect = 2e-18
Identities = 54/195 (27%), Positives = 103/195 (52%), Gaps = 4/195 (2%)
Query: 31 IRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKPWLGEGLLISSGPKWRSHRKM 90
+ +W+G + F V D IL A ++ + W+G GL+ G KW+ HR++
Sbjct: 80 VPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILESWVGRGLVTLDGSKWKKHRQI 139
Query: 91 IAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGKT--FDVHDYMSGTTVDILLETAMGIS 148
+ P F+I+ILK F+ + +++ ++ K + + + ++ ++S T+D +++ A
Sbjct: 140 VKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSHQ 199
Query: 149 RKTQDESGFD-YAMAVMKMCDIIHQRHYKFWMRSEIVFKLTSFFKQQTKLLGIIHGLTNK 207
Q +S D Y AV + I +QR F +++VFK +S + +K +H T K
Sbjct: 200 GSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFTEK 259
Query: 208 VIKNKKETYLENKAK 222
VI+++KE+ L++K K
Sbjct: 260 VIQDRKES-LKDKLK 273
>AL135960-6|CAI19734.1| 505|Homo sapiens cytochrome P450, family 4,
subfamily Z, polypeptide 1 protein.
Length = 505
Score = 147 bits (357), Expect = 7e-35
Identities = 74/204 (36%), Positives = 119/204 (58%), Gaps = 2/204 (0%)
Query: 248 SDTVFKGYRDDLDFNDENDVGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGH 307
++ V + ++ L + D +K+R FLD+++ + T S+ +++ EV T MF GH
Sbjct: 257 TEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSENTKDFSEADLQAEVKTFMFAGH 316
Query: 308 DTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRL 367
DTT++ S++L L + + Q R DE+ ++ GD T+ +M Y I E LRL
Sbjct: 317 DTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSS-ITWEHLSQMPYTTMCIKECLRL 375
Query: 368 YPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENT 427
Y PV I+R L++ +T +PAG TV I + LH P +++DP+VFNP F EN+
Sbjct: 376 YAPVVNISRLLDKPITFPDGRS-LPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENS 434
Query: 428 QNRHYYSYIPFSAGPRSCVGRKYA 451
+ H Y++IPFSAG R+C+G+ +A
Sbjct: 435 EKIHPYAFIPFSAGLRNCIGQHFA 458
Score = 93.5 bits (222), Expect = 2e-18
Identities = 54/195 (27%), Positives = 103/195 (52%), Gaps = 4/195 (2%)
Query: 31 IRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKPWLGEGLLISSGPKWRSHRKM 90
+ +W+G + F V D IL A ++ + W+G GL+ G KW+ HR++
Sbjct: 80 VPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILESWVGRGLVTLDGSKWKKHRQI 139
Query: 91 IAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGKT--FDVHDYMSGTTVDILLETAMGIS 148
+ P F+I+ILK F+ + +++ ++ K + + + ++ ++S T+D +++ A
Sbjct: 140 VKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSHQ 199
Query: 149 RKTQDESGFD-YAMAVMKMCDIIHQRHYKFWMRSEIVFKLTSFFKQQTKLLGIIHGLTNK 207
Q +S D Y AV + I +QR F +++VFK +S + +K +H T K
Sbjct: 200 GSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFTEK 259
Query: 208 VIKNKKETYLENKAK 222
VI+++KE+ L++K K
Sbjct: 260 VIQDRKES-LKDKLK 273
>L04751-1|AAA58436.1| 519|Homo sapiens cytochrome P450 protein.
Length = 519
Score = 147 bits (355), Expect = 1e-34
Identities = 76/229 (33%), Positives = 124/229 (54%), Gaps = 5/229 (2%)
Query: 267 VGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQD 326
+ K+ L FLD+++ + + +SD +++ EVDT MFEGHDTTA+G S++L L H
Sbjct: 283 IKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPK 342
Query: 327 VQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTIST 386
Q R +E++ + GD T+ +M Y I E+LRLYPPVP I R+L+ VT
Sbjct: 343 HQERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTF-P 400
Query: 387 KNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV 446
+P G V++ + LH PK + +PEVF+P F P + Q H ++++PFS G R+C+
Sbjct: 401 DGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQ--HSHAFLPFSGGSRNCI 458
Query: 447 GRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKV 495
G+++A F + + + ++LK G +++
Sbjct: 459 GKQFAMNELKVATALTLLRFELLPDPTRIPIPI-ARLVLKSKNGIHLRL 506
Score = 97.9 bits (233), Expect = 7e-20
Identities = 59/212 (27%), Positives = 111/212 (52%), Gaps = 6/212 (2%)
Query: 6 HVQEENLTQKLVNLALGYAQTFGNVIRVWL-GSKLIVFLVDADDIEIILNSHVHIDKATE 64
H+QE Q+L + + +TF + WL G K+ V L D D +++IL +
Sbjct: 62 HIQELQQDQELQRIQK-WVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGS- 119
Query: 65 YRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGK 124
YRF PW+G GLL+ +G W HR+M+ P FH +ILK +VG+ + +++K + +G+
Sbjct: 120 YRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQ 179
Query: 125 --TFDVHDYMSGTTVDILLETAMGISRKTQ-DESGFDYAMAVMKMCDIIHQRHYKFWMRS 181
+V ++S T+D +++ A Q D + Y A+ + +++ R + ++
Sbjct: 180 DSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQN 239
Query: 182 EIVFKLTSFFKQQTKLLGIIHGLTNKVIKNKK 213
+ ++ LTS + + + H T++VI+ +K
Sbjct: 240 DTIYSLTSAGRWTHRACQLAHQHTDQVIQLRK 271
>D26481-1|BAA05491.1| 519|Homo sapiens fatty acids
omega-hydroxylase protein.
Length = 519
Score = 147 bits (355), Expect = 1e-34
Identities = 76/229 (33%), Positives = 124/229 (54%), Gaps = 5/229 (2%)
Query: 267 VGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQD 326
+ K+ L FLD+++ + + +SD +++ EVDT MFEGHDTTA+G S++L L H
Sbjct: 283 IKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPK 342
Query: 327 VQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTIST 386
Q R +E++ + GD T+ +M Y I E+LRLYPPVP I R+L+ VT
Sbjct: 343 HQERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTF-P 400
Query: 387 KNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV 446
+P G V++ + LH PK + +PEVF+P F P + Q H ++++PFS G R+C+
Sbjct: 401 DGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQ--HSHAFLPFSGGSRNCI 458
Query: 447 GRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKV 495
G+++A F + + + ++LK G +++
Sbjct: 459 GKQFAMNELKVATALTLLRFELLPDPTRIPIPI-ARLVLKSKNGIHLRL 506
Score = 97.9 bits (233), Expect = 7e-20
Identities = 59/212 (27%), Positives = 111/212 (52%), Gaps = 6/212 (2%)
Query: 6 HVQEENLTQKLVNLALGYAQTFGNVIRVWL-GSKLIVFLVDADDIEIILNSHVHIDKATE 64
H+QE Q+L + + +TF + WL G K+ V L D D +++IL +
Sbjct: 62 HIQELQQDQELQRIQK-WVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGS- 119
Query: 65 YRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGK 124
YRF PW+G GLL+ +G W HR+M+ P FH +ILK +VG+ + +++K + +G+
Sbjct: 120 YRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQ 179
Query: 125 --TFDVHDYMSGTTVDILLETAMGISRKTQ-DESGFDYAMAVMKMCDIIHQRHYKFWMRS 181
+V ++S T+D +++ A Q D + Y A+ + +++ R + ++
Sbjct: 180 DSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQN 239
Query: 182 EIVFKLTSFFKQQTKLLGIIHGLTNKVIKNKK 213
+ ++ LTS + + + H T++VI+ +K
Sbjct: 240 DTIYSLTSAGRWTHRACQLAHQHTDQVIQLRK 271
>AY369778-1|AAQ56847.1| 519|Homo sapiens cytochrome P450, family 4,
subfamily A, polypeptide 11 protein.
Length = 519
Score = 147 bits (355), Expect = 1e-34
Identities = 76/229 (33%), Positives = 124/229 (54%), Gaps = 5/229 (2%)
Query: 267 VGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQD 326
+ K+ L FLD+++ + + +SD +++ EVDT MFEGHDTTA+G S++L L H
Sbjct: 283 IKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPK 342
Query: 327 VQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTIST 386
Q R +E++ + GD T+ +M Y I E+LRLYPPVP I R+L+ VT
Sbjct: 343 HQERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTF-P 400
Query: 387 KNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV 446
+P G V++ + LH PK + +PEVF+P F P + Q H ++++PFS G R+C+
Sbjct: 401 DGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQ--HSHAFLPFSGGSRNCI 458
Query: 447 GRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKV 495
G+++A F + + + ++LK G +++
Sbjct: 459 GKQFAMNELKVATALTLLRFELLPDPTRIPIPI-ARLVLKSKNGIHLRL 506
Score = 97.9 bits (233), Expect = 7e-20
Identities = 59/212 (27%), Positives = 111/212 (52%), Gaps = 6/212 (2%)
Query: 6 HVQEENLTQKLVNLALGYAQTFGNVIRVWL-GSKLIVFLVDADDIEIILNSHVHIDKATE 64
H+QE Q+L + + +TF + WL G K+ V L D D +++IL +
Sbjct: 62 HIQELQQDQELQRIQK-WVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGS- 119
Query: 65 YRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGK 124
YRF PW+G GLL+ +G W HR+M+ P FH +ILK +VG+ + +++K + +G+
Sbjct: 120 YRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQ 179
Query: 125 --TFDVHDYMSGTTVDILLETAMGISRKTQ-DESGFDYAMAVMKMCDIIHQRHYKFWMRS 181
+V ++S T+D +++ A Q D + Y A+ + +++ R + ++
Sbjct: 180 DSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQN 239
Query: 182 EIVFKLTSFFKQQTKLLGIIHGLTNKVIKNKK 213
+ ++ LTS + + + H T++VI+ +K
Sbjct: 240 DTIYSLTSAGRWTHRACQLAHQHTDQVIQLRK 271
>AL731892-3|CAH72778.1| 519|Homo sapiens cytochrome P450, family 4,
subfamily A, polypeptide 11 protein.
Length = 519
Score = 147 bits (355), Expect = 1e-34
Identities = 76/229 (33%), Positives = 124/229 (54%), Gaps = 5/229 (2%)
Query: 267 VGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQD 326
+ K+ L FLD+++ + + +SD +++ EVDT MFEGHDTTA+G S++L L H
Sbjct: 283 IKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPK 342
Query: 327 VQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTIST 386
Q R +E++ + GD T+ +M Y I E+LRLYPPVP I R+L+ VT
Sbjct: 343 HQERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTF-P 400
Query: 387 KNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV 446
+P G V++ + LH PK + +PEVF+P F P + Q H ++++PFS G R+C+
Sbjct: 401 DGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQ--HSHAFLPFSGGSRNCI 458
Query: 447 GRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKV 495
G+++A F + + + ++LK G +++
Sbjct: 459 GKQFAMNELKVATALTLLRFELLPDPTRIPIPI-ARLVLKSKNGIHLRL 506
Score = 97.9 bits (233), Expect = 7e-20
Identities = 59/212 (27%), Positives = 111/212 (52%), Gaps = 6/212 (2%)
Query: 6 HVQEENLTQKLVNLALGYAQTFGNVIRVWL-GSKLIVFLVDADDIEIILNSHVHIDKATE 64
H+QE Q+L + + +TF + WL G K+ V L D D +++IL +
Sbjct: 62 HIQELQQDQELQRIQK-WVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGS- 119
Query: 65 YRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGK 124
YRF PW+G GLL+ +G W HR+M+ P FH +ILK +VG+ + +++K + +G+
Sbjct: 120 YRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQ 179
Query: 125 --TFDVHDYMSGTTVDILLETAMGISRKTQ-DESGFDYAMAVMKMCDIIHQRHYKFWMRS 181
+V ++S T+D +++ A Q D + Y A+ + +++ R + ++
Sbjct: 180 DSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQN 239
Query: 182 EIVFKLTSFFKQQTKLLGIIHGLTNKVIKNKK 213
+ ++ LTS + + + H T++VI+ +K
Sbjct: 240 DTIYSLTSAGRWTHRACQLAHQHTDQVIQLRK 271
>D13705-1|BAA02864.1| 521|Homo sapiens fatty acid omega-hydroxylase
protein.
Length = 521
Score = 146 bits (354), Expect = 2e-34
Identities = 72/185 (38%), Positives = 112/185 (60%), Gaps = 4/185 (2%)
Query: 267 VGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQD 326
+ K+ L FLD+++ + + +SD +++ EVDT MFEGHDTTA+G S++L L H
Sbjct: 284 IKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPK 343
Query: 327 VQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTIST 386
Q R +E++ + GD T+ +M Y I E+LRLYPPVP I R+L+ VT
Sbjct: 344 HQERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTF-P 401
Query: 387 KNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV 446
+P G V++ + LH PK + +PEVF+P F P + Q H ++++PFS G R+C+
Sbjct: 402 DGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQ--HSHAFLPFSGGSRNCI 459
Query: 447 GRKYA 451
G+++A
Sbjct: 460 GKQFA 464
Score = 94.3 bits (224), Expect = 9e-19
Identities = 60/213 (28%), Positives = 110/213 (51%), Gaps = 7/213 (3%)
Query: 6 HVQEENLTQKLVNLALGYAQTFGNVIRVWL-GSKLIVFLVDADDIEIILNSHVHIDKATE 64
H+QE Q+L + + +TF + WL G K+ V L D D +++IL +
Sbjct: 62 HIQELQQDQELQRIQK-WVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGS- 119
Query: 65 YRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGK 124
YRF PW+G GLL+ +G W HR+M+ P FH +ILK +VG+ + +++K + +G+
Sbjct: 120 YRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQ 179
Query: 125 --TFDVHDYMSGTTVDILLETAMGISRKTQ-DESGFDYAMAVMKMCDIIHQRHYKFWMRS 181
+V ++S T+D +++ A Q D + Y A+ + +++ R + ++
Sbjct: 180 DSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQN 239
Query: 182 EIVFKLTSFFKQQTKLLGIIHGLTN-KVIKNKK 213
+ ++ LTS + + + H T KVI+ +K
Sbjct: 240 DTIYSLTSAGRWTHRACQLSHQHTRPKVIQLRK 272
>AF525488-1|AAO16078.1| 519|Homo sapiens cytochrome P450, subfamily
IVA, polypeptide 11 protein.
Length = 519
Score = 145 bits (351), Expect = 4e-34
Identities = 75/229 (32%), Positives = 124/229 (54%), Gaps = 5/229 (2%)
Query: 267 VGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQD 326
+ K+ L FLD+++ + + +SD +++ EVDT MFEGHDTTA+G S++L L H
Sbjct: 283 IKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPK 342
Query: 327 VQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTIST 386
Q R +E++ + GD T+ +M Y I E+LRL+PPVP I R+L+ VT
Sbjct: 343 HQERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLFPPVPGIGRELSTPVTF-P 400
Query: 387 KNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV 446
+P G V++ + LH PK + +PEVF+P F P + Q H ++++PFS G R+C+
Sbjct: 401 DGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQ--HSHAFLPFSGGSRNCI 458
Query: 447 GRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKV 495
G+++A F + + + ++LK G +++
Sbjct: 459 GKQFAMNELKVATALTLLRFELLPDPTRIPIPI-ARLVLKSKNGIHLRL 506
Score = 97.9 bits (233), Expect = 7e-20
Identities = 59/212 (27%), Positives = 111/212 (52%), Gaps = 6/212 (2%)
Query: 6 HVQEENLTQKLVNLALGYAQTFGNVIRVWL-GSKLIVFLVDADDIEIILNSHVHIDKATE 64
H+QE Q+L + + +TF + WL G K+ V L D D +++IL +
Sbjct: 62 HIQELQQDQELQRIQK-WVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGS- 119
Query: 65 YRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGK 124
YRF PW+G GLL+ +G W HR+M+ P FH +ILK +VG+ + +++K + +G+
Sbjct: 120 YRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQ 179
Query: 125 --TFDVHDYMSGTTVDILLETAMGISRKTQ-DESGFDYAMAVMKMCDIIHQRHYKFWMRS 181
+V ++S T+D +++ A Q D + Y A+ + +++ R + ++
Sbjct: 180 DSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQN 239
Query: 182 EIVFKLTSFFKQQTKLLGIIHGLTNKVIKNKK 213
+ ++ LTS + + + H T++VI+ +K
Sbjct: 240 DTIYSLTSAGRWTHRACQLAHQHTDQVIQLRK 271
>BC028102-1|AAH28102.1| 509|Homo sapiens cytochrome P450, family 4,
subfamily X, polypeptide 1 protein.
Length = 509
Score = 144 bits (350), Expect = 5e-34
Identities = 80/250 (32%), Positives = 130/250 (52%), Gaps = 4/250 (1%)
Query: 248 SDTVFKGYRDDLDFNDENDVGEKKRLA-FLDLMIESSQNGTNKISDHEIKEEVDTIMFEG 306
+DT+ + + L + D K++ FLD+++ + + SD ++ EV T + G
Sbjct: 258 TDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAG 317
Query: 307 HDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLR 366
HDT AA S++L L ++ + Q R +E+ I GD T+ EM Y I E+ R
Sbjct: 318 HDTLAASISWILYCLALNPEHQERCREEVRGILGDGSS-ITWDQLGEMSYTTMCIKETCR 376
Query: 367 LYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPEN 426
L P VP I+R L++ +T +PAG TVV+ + LH P +K+P+VF+P F EN
Sbjct: 377 LIPAVPSISRDLSKPLTFPD-GCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQEN 435
Query: 427 TQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILK 486
+ RH Y+Y+PFSAG R+C+G+++A +FR ++ P + ILK
Sbjct: 436 SDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFR-VTPDPTRPLTFPNHFILK 494
Query: 487 RAEGFQMKVE 496
G + ++
Sbjct: 495 PKNGMYLHLK 504
Score = 95.9 bits (228), Expect = 3e-19
Identities = 60/216 (27%), Positives = 115/216 (53%), Gaps = 15/216 (6%)
Query: 7 VQEENLTQKLVNLALGYAQTFGNVIRVWLGSKLIVFLV-DADDIEIILNSHVHIDKATEY 65
+Q++N+ +KL + Y + F W+G F + D D + +L+ D ++Y
Sbjct: 61 IQDDNM-EKLEEIIEKYPRAFP----FWIGPFQAFFCIYDPDYAKTLLS---RTDPKSQY 112
Query: 66 --RFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVV---EKLKS 120
+F P LG+GL GPKW HR+++ P FH NILK+++ + + ++ EK+ S
Sbjct: 113 LQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICS 172
Query: 121 EVGKTFDVHDYMSGTTVDILLETAMGISRKTQDESGFD-YAMAVMKMCDIIHQRHYKFWM 179
+ +V+++++ ++DI+++ A Q S D YA A+ ++ II R Y
Sbjct: 173 TQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLY 232
Query: 180 RSEIVFKLTSFFKQQTKLLGIIHGLTNKVIKNKKET 215
S+I+FKL+ + KL +++ T+ +I+ +K++
Sbjct: 233 HSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKS 268
>AY358537-1|AAQ88901.1| 509|Homo sapiens EFSW1929 protein.
Length = 509
Score = 144 bits (350), Expect = 5e-34
Identities = 80/250 (32%), Positives = 130/250 (52%), Gaps = 4/250 (1%)
Query: 248 SDTVFKGYRDDLDFNDENDVGEKKRLA-FLDLMIESSQNGTNKISDHEIKEEVDTIMFEG 306
+DT+ + + L + D K++ FLD+++ + + SD ++ EV T + G
Sbjct: 258 TDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAG 317
Query: 307 HDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLR 366
HDT AA S++L L ++ + Q R +E+ I GD T+ EM Y I E+ R
Sbjct: 318 HDTLAASISWILYCLALNPEHQERCREEVRGILGDGSS-ITWDQLGEMSYTTMCIKETCR 376
Query: 367 LYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPEN 426
L P VP I+R L++ +T +PAG TVV+ + LH P +K+P+VF+P F EN
Sbjct: 377 LIPAVPSISRDLSKPLTFPD-GCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQEN 435
Query: 427 TQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILK 486
+ RH Y+Y+PFSAG R+C+G+++A +FR ++ P + ILK
Sbjct: 436 SDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFR-VTPDPTRPLTFPNHFILK 494
Query: 487 RAEGFQMKVE 496
G + ++
Sbjct: 495 PKNGMYLHLK 504
Score = 95.9 bits (228), Expect = 3e-19
Identities = 60/216 (27%), Positives = 115/216 (53%), Gaps = 15/216 (6%)
Query: 7 VQEENLTQKLVNLALGYAQTFGNVIRVWLGSKLIVFLV-DADDIEIILNSHVHIDKATEY 65
+Q++N+ +KL + Y + F W+G F + D D + +L+ D ++Y
Sbjct: 61 IQDDNM-EKLEEIIEKYPRAFP----FWIGPFQAFFCIYDPDYAKTLLS---RTDPKSQY 112
Query: 66 --RFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVV---EKLKS 120
+F P LG+GL GPKW HR+++ P FH NILK+++ + + ++ EK+ S
Sbjct: 113 LQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICS 172
Query: 121 EVGKTFDVHDYMSGTTVDILLETAMGISRKTQDESGFD-YAMAVMKMCDIIHQRHYKFWM 179
+ +V+++++ ++DI+++ A Q S D YA A+ ++ II R Y
Sbjct: 173 TQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLY 232
Query: 180 RSEIVFKLTSFFKQQTKLLGIIHGLTNKVIKNKKET 215
S+I+FKL+ + KL +++ T+ +I+ +K++
Sbjct: 233 HSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKS 268
>AM040940-1|CAJ13826.1| 509|Homo sapiens cytochrome P450 protein.
Length = 509
Score = 144 bits (350), Expect = 5e-34
Identities = 80/250 (32%), Positives = 130/250 (52%), Gaps = 4/250 (1%)
Query: 248 SDTVFKGYRDDLDFNDENDVGEKKRLA-FLDLMIESSQNGTNKISDHEIKEEVDTIMFEG 306
+DT+ + + L + D K++ FLD+++ + + SD ++ EV T + G
Sbjct: 258 TDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAG 317
Query: 307 HDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLR 366
HDT AA S++L L ++ + Q R +E+ I GD T+ EM Y I E+ R
Sbjct: 318 HDTLAASISWILYCLALNPEHQERCREEVRGILGDGSS-ITWDQLGEMSYTTMCIKETCR 376
Query: 367 LYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPEN 426
L P VP I+R L++ +T +PAG TVV+ + LH P +K+P+VF+P F EN
Sbjct: 377 LIPAVPSISRDLSKPLTFPD-GCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQEN 435
Query: 427 TQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILK 486
+ RH Y+Y+PFSAG R+C+G+++A +FR ++ P + ILK
Sbjct: 436 SDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFR-VTPDPTRPLTFPNHFILK 494
Query: 487 RAEGFQMKVE 496
G + ++
Sbjct: 495 PKNGMYLHLK 504
Score = 95.9 bits (228), Expect = 3e-19
Identities = 60/216 (27%), Positives = 115/216 (53%), Gaps = 15/216 (6%)
Query: 7 VQEENLTQKLVNLALGYAQTFGNVIRVWLGSKLIVFLV-DADDIEIILNSHVHIDKATEY 65
+Q++N+ +KL + Y + F W+G F + D D + +L+ D ++Y
Sbjct: 61 IQDDNM-EKLEEIIEKYPRAFP----FWIGPFQAFFCIYDPDYAKTLLS---RTDPKSQY 112
Query: 66 --RFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVV---EKLKS 120
+F P LG+GL GPKW HR+++ P FH NILK+++ + + ++ EK+ S
Sbjct: 113 LQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICS 172
Query: 121 EVGKTFDVHDYMSGTTVDILLETAMGISRKTQDESGFD-YAMAVMKMCDIIHQRHYKFWM 179
+ +V+++++ ++DI+++ A Q S D YA A+ ++ II R Y
Sbjct: 173 TQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLY 232
Query: 180 RSEIVFKLTSFFKQQTKLLGIIHGLTNKVIKNKKET 215
S+I+FKL+ + KL +++ T+ +I+ +K++
Sbjct: 233 HSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKS 268
>AL450996-1|CAH71035.1| 509|Homo sapiens cytochrome P450, family 4,
subfamily X, polypeptide 1 protein.
Length = 509
Score = 144 bits (350), Expect = 5e-34
Identities = 80/250 (32%), Positives = 130/250 (52%), Gaps = 4/250 (1%)
Query: 248 SDTVFKGYRDDLDFNDENDVGEKKRLA-FLDLMIESSQNGTNKISDHEIKEEVDTIMFEG 306
+DT+ + + L + D K++ FLD+++ + + SD ++ EV T + G
Sbjct: 258 TDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAG 317
Query: 307 HDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLR 366
HDT AA S++L L ++ + Q R +E+ I GD T+ EM Y I E+ R
Sbjct: 318 HDTLAASISWILYCLALNPEHQERCREEVRGILGDGSS-ITWDQLGEMSYTTMCIKETCR 376
Query: 367 LYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPEN 426
L P VP I+R L++ +T +PAG TVV+ + LH P +K+P+VF+P F EN
Sbjct: 377 LIPAVPSISRDLSKPLTFPD-GCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQEN 435
Query: 427 TQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILK 486
+ RH Y+Y+PFSAG R+C+G+++A +FR ++ P + ILK
Sbjct: 436 SDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFR-VTPDPTRPLTFPNHFILK 494
Query: 487 RAEGFQMKVE 496
G + ++
Sbjct: 495 PKNGMYLHLK 504
Score = 95.9 bits (228), Expect = 3e-19
Identities = 60/216 (27%), Positives = 115/216 (53%), Gaps = 15/216 (6%)
Query: 7 VQEENLTQKLVNLALGYAQTFGNVIRVWLGSKLIVFLV-DADDIEIILNSHVHIDKATEY 65
+Q++N+ +KL + Y + F W+G F + D D + +L+ D ++Y
Sbjct: 61 IQDDNM-EKLEEIIEKYPRAFP----FWIGPFQAFFCIYDPDYAKTLLS---RTDPKSQY 112
Query: 66 --RFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVV---EKLKS 120
+F P LG+GL GPKW HR+++ P FH NILK+++ + + ++ EK+ S
Sbjct: 113 LQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICS 172
Query: 121 EVGKTFDVHDYMSGTTVDILLETAMGISRKTQDESGFD-YAMAVMKMCDIIHQRHYKFWM 179
+ +V+++++ ++DI+++ A Q S D YA A+ ++ II R Y
Sbjct: 173 TQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLY 232
Query: 180 RSEIVFKLTSFFKQQTKLLGIIHGLTNKVIKNKKET 215
S+I+FKL+ + KL +++ T+ +I+ +K++
Sbjct: 233 HSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKS 268
>AK131355-1|BAD18508.1| 508|Homo sapiens protein ( Homo sapiens
cDNA FLJ16384 fis, clone TLIVE2007607, weakly similar
to CYTOCHROME P450 4A4 (EC 1.14.14.1). ).
Length = 508
Score = 144 bits (350), Expect = 5e-34
Identities = 80/250 (32%), Positives = 130/250 (52%), Gaps = 4/250 (1%)
Query: 248 SDTVFKGYRDDLDFNDENDVGEKKRLA-FLDLMIESSQNGTNKISDHEIKEEVDTIMFEG 306
+DT+ + + L + D K++ FLD+++ + + SD ++ EV T + G
Sbjct: 257 TDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAG 316
Query: 307 HDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLR 366
HDT AA S++L L ++ + Q R +E+ I GD T+ EM Y I E+ R
Sbjct: 317 HDTLAASISWILYCLALNPEHQERCREEVRGILGDGSS-ITWDQLGEMSYTTMCIKETCR 375
Query: 367 LYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPEN 426
L P VP I+R L++ +T +PAG TVV+ + LH P +K+P+VF+P F EN
Sbjct: 376 LIPAVPSISRDLSKPLTFPD-GCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQEN 434
Query: 427 TQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILK 486
+ RH Y+Y+PFSAG R+C+G+++A +FR ++ P + ILK
Sbjct: 435 SDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFR-VTPDPTRPLTFPNHFILK 493
Query: 487 RAEGFQMKVE 496
G + ++
Sbjct: 494 PKNGMYLHLK 503
Score = 95.9 bits (228), Expect = 3e-19
Identities = 60/218 (27%), Positives = 116/218 (53%), Gaps = 15/218 (6%)
Query: 5 IHVQEENLTQKLVNLALGYAQTFGNVIRVWLGSKLIVFLV-DADDIEIILNSHVHIDKAT 63
+ +Q++N+ +KL + Y + F W+G F + D D + +L+ D +
Sbjct: 58 LFIQDDNM-EKLEEIIEKYPRAFP----FWIGPFQAFFCIYDPDYAKTLLS---RTDPKS 109
Query: 64 EY--RFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVV---EKL 118
+Y +F P LG+GL GPKW HR+++ P FH NILK+++ + + ++ EK+
Sbjct: 110 QYLQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKI 169
Query: 119 KSEVGKTFDVHDYMSGTTVDILLETAMGISRKTQDESGFD-YAMAVMKMCDIIHQRHYKF 177
S + +V+++++ ++DI+++ A Q S D YA A+ ++ II R Y
Sbjct: 170 CSTQDTSVEVYEHINSMSLDIVMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSL 229
Query: 178 WMRSEIVFKLTSFFKQQTKLLGIIHGLTNKVIKNKKET 215
S+I+FKL+ + KL +++ T+ +I+ +K++
Sbjct: 230 LYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKS 267
>AK098065-1|BAC05226.1| 509|Homo sapiens protein ( Homo sapiens
cDNA FLJ40746 fis, clone TRACH2000359, weakly similar to
CYTOCHROME P450 4A4 (EC 1.14.14.1). ).
Length = 509
Score = 144 bits (350), Expect = 5e-34
Identities = 80/250 (32%), Positives = 130/250 (52%), Gaps = 4/250 (1%)
Query: 248 SDTVFKGYRDDLDFNDENDVGEKKRLA-FLDLMIESSQNGTNKISDHEIKEEVDTIMFEG 306
+DT+ + + L + D K++ FLD+++ + + SD ++ EV T + G
Sbjct: 258 TDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAG 317
Query: 307 HDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLR 366
HDT AA S++L L ++ + Q R +E+ I GD T+ EM Y I E+ R
Sbjct: 318 HDTLAASISWILYCLALNPEHQERCREEVRGILGDGSS-ITWDQLGEMSYTTMCIKETCR 376
Query: 367 LYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPEN 426
L P VP I+R L++ +T +PAG TVV+ + LH P +K+P+VF+P F EN
Sbjct: 377 LIPAVPSISRDLSKPLTFPD-GCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQEN 435
Query: 427 TQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILK 486
+ RH Y+Y+PFSAG R+C+G+++A +FR ++ P + ILK
Sbjct: 436 SDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFR-VTPDPTRPLTFPNHFILK 494
Query: 487 RAEGFQMKVE 496
G + ++
Sbjct: 495 PKNGMYLHLK 504
Score = 95.9 bits (228), Expect = 3e-19
Identities = 60/216 (27%), Positives = 115/216 (53%), Gaps = 15/216 (6%)
Query: 7 VQEENLTQKLVNLALGYAQTFGNVIRVWLGSKLIVFLV-DADDIEIILNSHVHIDKATEY 65
+Q++N+ +KL + Y + F W+G F + D D + +L+ D ++Y
Sbjct: 61 IQDDNM-EKLEEIIEKYPRAFP----FWIGPFQAFFCIYDPDYAKTLLS---RTDPKSQY 112
Query: 66 --RFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVV---EKLKS 120
+F P LG+GL GPKW HR+++ P FH NILK+++ + + ++ EK+ S
Sbjct: 113 LQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICS 172
Query: 121 EVGKTFDVHDYMSGTTVDILLETAMGISRKTQDESGFD-YAMAVMKMCDIIHQRHYKFWM 179
+ +V+++++ ++DI+++ A Q S D YA A+ ++ II R Y
Sbjct: 173 TQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLY 232
Query: 180 RSEIVFKLTSFFKQQTKLLGIIHGLTNKVIKNKKET 215
S+I+FKL+ + KL +++ T+ +I+ +K++
Sbjct: 233 HSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKS 268
>AK091806-1|BAC03751.1| 444|Homo sapiens protein ( Homo sapiens
cDNA FLJ34487 fis, clone HLUNG2004273, weakly similar to
CYTOCHROME P450 4A4 (EC 1.14.14.1). ).
Length = 444
Score = 144 bits (350), Expect = 5e-34
Identities = 80/250 (32%), Positives = 130/250 (52%), Gaps = 4/250 (1%)
Query: 248 SDTVFKGYRDDLDFNDENDVGEKKRLA-FLDLMIESSQNGTNKISDHEIKEEVDTIMFEG 306
+DT+ + + L + D K++ FLD+++ + + SD ++ EV T + G
Sbjct: 193 TDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAG 252
Query: 307 HDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLR 366
HDT AA S++L L ++ + Q R +E+ I GD T+ EM Y I E+ R
Sbjct: 253 HDTLAASISWILYCLALNPEHQERCREEVRGILGDGSS-ITWDQLGEMSYTTMCIKETCR 311
Query: 367 LYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPEN 426
L P VP I+R L++ +T +PAG TVV+ + LH P +K+P+VF+P F EN
Sbjct: 312 LIPAVPSISRDLSKPLTFPD-GCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQEN 370
Query: 427 TQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILK 486
+ RH Y+Y+PFSAG R+C+G+++A +FR ++ P + ILK
Sbjct: 371 SDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFR-VTPDPTRPLTFPNHFILK 429
Query: 487 RAEGFQMKVE 496
G + ++
Sbjct: 430 PKNGMYLHLK 439
Score = 93.1 bits (221), Expect = 2e-18
Identities = 54/189 (28%), Positives = 102/189 (53%), Gaps = 10/189 (5%)
Query: 34 WLGSKLIVFLV-DADDIEIILNSHVHIDKATEY--RFFKPWLGEGLLISSGPKWRSHRKM 90
W+G F + D D + +L+ D ++Y +F P LG+GL GPKW HR++
Sbjct: 18 WIGPFQAFFCIYDPDYAKTLLS---RTDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRL 74
Query: 91 IAPTFHINILKSFVGIFNQNSNNVV---EKLKSEVGKTFDVHDYMSGTTVDILLETAMGI 147
+ P FH NILK+++ + + ++ EK+ S + +V+++++ ++DI+++ A
Sbjct: 75 LTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSK 134
Query: 148 SRKTQDESGFD-YAMAVMKMCDIIHQRHYKFWMRSEIVFKLTSFFKQQTKLLGIIHGLTN 206
Q S D YA A+ ++ II R Y S+I+FKL+ + KL +++ T+
Sbjct: 135 ETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTD 194
Query: 207 KVIKNKKET 215
+I+ +K++
Sbjct: 195 TIIQERKKS 203
>BC093896-1|AAH93896.1| 531|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 2 homolog protein.
Length = 531
Score = 144 bits (349), Expect = 6e-34
Identities = 72/228 (31%), Positives = 125/228 (54%), Gaps = 3/228 (1%)
Query: 271 KRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQAR 330
K L F+D+++ + ++SD +I+ E DT MFEGHDTT++G S++L L + + Q +
Sbjct: 301 KTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEK 360
Query: 331 VYDELYQIF-GDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTKNY 389
+E+ ++ G + D ++ + I ESLR YPPV +++R+ D+ +
Sbjct: 361 CREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGR- 419
Query: 390 VIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRK 449
+IP G ++ + H P + D +V+NP F P+N Q R +Y+PFSAGPR+C+G+
Sbjct: 420 IIPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQS 479
Query: 450 YAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
+A FR +S ++ + + ++IL+ G +KVEP
Sbjct: 480 FAMAELRVVVALTLLRFR-LSVDRTRKVRRKPELILRTENGLWLKVEP 526
Score = 99.1 bits (236), Expect = 3e-20
Identities = 55/200 (27%), Positives = 109/200 (54%), Gaps = 7/200 (3%)
Query: 29 NVIRVWLGSKL-IVFLVDADDIEIILNSHVHIDKATE--YRFFKPWLGEGLLISSGPKWR 85
+V+ VW+G L ++ LV D I+ +L + I + Y F KPWLG+GLL+S G KW
Sbjct: 94 HVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDKWS 153
Query: 86 SHRKMIAPTFHINILKSFVGIFNQNSNNVVEK---LKSEVGKTFDVHDYMSGTTVDILLE 142
HR+++ P FH +ILK ++ IFNQ+++ + K L + D+ +++S T+D L +
Sbjct: 154 RHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQK 213
Query: 143 TAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSEIVFKLTSFFKQQTKLLGIIH 202
+ Q++ DY A++++ + +R Y+ + ++ ++ ++ + ++H
Sbjct: 214 CVFSYNSNCQEKMS-DYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVH 272
Query: 203 GLTNKVIKNKKETYLENKAK 222
T +VI+ ++ + A+
Sbjct: 273 HFTTEVIQERRRALRQQGAE 292
>BC093894-1|AAH93894.1| 531|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 2 homolog protein.
Length = 531
Score = 144 bits (349), Expect = 6e-34
Identities = 72/228 (31%), Positives = 125/228 (54%), Gaps = 3/228 (1%)
Query: 271 KRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQAR 330
K L F+D+++ + ++SD +I+ E DT MFEGHDTT++G S++L L + + Q +
Sbjct: 301 KTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEK 360
Query: 331 VYDELYQIF-GDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTKNY 389
+E+ ++ G + D ++ + I ESLR YPPV +++R+ D+ +
Sbjct: 361 CREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGR- 419
Query: 390 VIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRK 449
+IP G ++ + H P + D +V+NP F P+N Q R +Y+PFSAGPR+C+G+
Sbjct: 420 IIPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQS 479
Query: 450 YAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
+A FR +S ++ + + ++IL+ G +KVEP
Sbjct: 480 FAMAELRVVVALTLLRFR-LSVDRTRKVRRKPELILRTENGLWLKVEP 526
Score = 99.1 bits (236), Expect = 3e-20
Identities = 55/200 (27%), Positives = 109/200 (54%), Gaps = 7/200 (3%)
Query: 29 NVIRVWLGSKL-IVFLVDADDIEIILNSHVHIDKATE--YRFFKPWLGEGLLISSGPKWR 85
+V+ VW+G L ++ LV D I+ +L + I + Y F KPWLG+GLL+S G KW
Sbjct: 94 HVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDKWS 153
Query: 86 SHRKMIAPTFHINILKSFVGIFNQNSNNVVEK---LKSEVGKTFDVHDYMSGTTVDILLE 142
HR+++ P FH +ILK ++ IFNQ+++ + K L + D+ +++S T+D L +
Sbjct: 154 RHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQK 213
Query: 143 TAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSEIVFKLTSFFKQQTKLLGIIH 202
+ Q++ DY A++++ + +R Y+ + ++ ++ ++ + ++H
Sbjct: 214 CVFSYNSNCQEKMS-DYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVH 272
Query: 203 GLTNKVIKNKKETYLENKAK 222
T +VI+ ++ + A+
Sbjct: 273 HFTTEVIQERRRALRQQGAE 292
>BC069351-1|AAH69351.1| 531|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 2 homolog protein.
Length = 531
Score = 144 bits (349), Expect = 6e-34
Identities = 72/228 (31%), Positives = 125/228 (54%), Gaps = 3/228 (1%)
Query: 271 KRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQAR 330
K L F+D+++ + ++SD +I+ E DT MFEGHDTT++G S++L L + + Q +
Sbjct: 301 KTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEK 360
Query: 331 VYDELYQIF-GDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTKNY 389
+E+ ++ G + D ++ + I ESLR YPPV +++R+ D+ +
Sbjct: 361 CREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGR- 419
Query: 390 VIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRK 449
+IP G ++ + H P + D +V+NP F P+N Q R +Y+PFSAGPR+C+G+
Sbjct: 420 IIPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQS 479
Query: 450 YAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
+A FR +S ++ + + ++IL+ G +KVEP
Sbjct: 480 FAMAELRVVVALTLLRFR-LSVDRTRKVRRKPELILRTENGLWLKVEP 526
Score = 99.1 bits (236), Expect = 3e-20
Identities = 55/200 (27%), Positives = 109/200 (54%), Gaps = 7/200 (3%)
Query: 29 NVIRVWLGSKL-IVFLVDADDIEIILNSHVHIDKATE--YRFFKPWLGEGLLISSGPKWR 85
+V+ VW+G L ++ LV D I+ +L + I + Y F KPWLG+GLL+S G KW
Sbjct: 94 HVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDKWS 153
Query: 86 SHRKMIAPTFHINILKSFVGIFNQNSNNVVEK---LKSEVGKTFDVHDYMSGTTVDILLE 142
HR+++ P FH +ILK ++ IFNQ+++ + K L + D+ +++S T+D L +
Sbjct: 154 RHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQK 213
Query: 143 TAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSEIVFKLTSFFKQQTKLLGIIH 202
+ Q++ DY A++++ + +R Y+ + ++ ++ ++ + ++H
Sbjct: 214 CVFSYNSNCQEKMS-DYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVH 272
Query: 203 GLTNKVIKNKKETYLENKAK 222
T +VI+ ++ + A+
Sbjct: 273 HFTTEVIQERRRALRQQGAE 292
>AK096820-1|BAC04868.1| 531|Homo sapiens protein ( Homo sapiens
cDNA FLJ39501 fis, clone PROST2016980, moderately
similar to CYTOCHROME P450 4F2 (EC 1.14.13.30). ).
Length = 531
Score = 144 bits (349), Expect = 6e-34
Identities = 72/228 (31%), Positives = 125/228 (54%), Gaps = 3/228 (1%)
Query: 271 KRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQAR 330
K L F+D+++ + ++SD +I+ E DT MFEGHDTT++G S++L L + + Q +
Sbjct: 301 KTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEK 360
Query: 331 VYDELYQIF-GDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTKNY 389
+E+ ++ G + D ++ + I ESLR YPPV +++R+ D+ +
Sbjct: 361 CREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGR- 419
Query: 390 VIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRK 449
+IP G ++ + H P + D +V+NP F P+N Q R +Y+PFSAGPR+C+G+
Sbjct: 420 IIPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQS 479
Query: 450 YAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEP 497
+A FR +S ++ + + ++IL+ G +KVEP
Sbjct: 480 FAMAELRVVVALTLLRFR-LSVDRTRKVRRKPELILRTENGLWLKVEP 526
Score = 96.3 bits (229), Expect = 2e-19
Identities = 53/191 (27%), Positives = 105/191 (54%), Gaps = 7/191 (3%)
Query: 29 NVIRVWLGSKL-IVFLVDADDIEIILNSHVHIDKATE--YRFFKPWLGEGLLISSGPKWR 85
+V+ VW+G L ++ LV D I+ +L + + Y F KPWLG+GLL+S G KW
Sbjct: 94 HVLLVWMGPVLPLLVLVHPDYIKPLLGASAATAPKDDLFYGFLKPWLGDGLLLSKGDKWS 153
Query: 86 SHRKMIAPTFHINILKSFVGIFNQNSNNVVEK---LKSEVGKTFDVHDYMSGTTVDILLE 142
HR+++ P FH +ILK ++ IFNQ+++ + K L + D+ +++S T+D L +
Sbjct: 154 RHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQK 213
Query: 143 TAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSEIVFKLTSFFKQQTKLLGIIH 202
+ Q++ DY A++++ + +R Y+ + ++ ++ ++ + ++H
Sbjct: 214 CVFSYNSNCQEKMS-DYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVH 272
Query: 203 GLTNKVIKNKK 213
T +VI+ ++
Sbjct: 273 HFTTEVIQERR 283
>AL135960-10|CAI19737.1| 519|Homo sapiens cytochrome P450, family
4, subfamily A, polypeptide 22 protein.
Length = 519
Score = 143 bits (347), Expect = 1e-33
Identities = 76/229 (33%), Positives = 124/229 (54%), Gaps = 5/229 (2%)
Query: 267 VGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQD 326
+ K+ L FLD+++ + + +SD +++ EVDT MFEGHDTTA+G S++L L H
Sbjct: 283 IKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPK 342
Query: 327 VQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTIST 386
Q R +E++ + GD T+ +M Y I E+LRLYPPVP I R+L+ VT
Sbjct: 343 HQERCREEIHGLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTF-P 400
Query: 387 KNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV 446
+P G V++ + LH PK + + EVF+P F P + Q H ++++PFS G R+C+
Sbjct: 401 DGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSAQ--HSHAFLPFSGGSRNCI 458
Query: 447 GRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDIILKRAEGFQMKV 495
G+++A F + + P + ++LK G +++
Sbjct: 459 GKQFAMNQLKVARALTLLRFELLPD-PTRIPIPMARLVLKSKNGIHLRL 506
Score = 83.8 bits (198), Expect = 1e-15
Identities = 55/212 (25%), Positives = 107/212 (50%), Gaps = 6/212 (2%)
Query: 6 HVQEENLTQKLVNLALGYAQTFGNVIRVWL-GSKLIVFLVDADDIEIILNSHVHIDKATE 64
H+QE Q+L + +TF + W+ G K+ V L D D +++IL +
Sbjct: 62 HIQEFQHDQELQRIQ-ERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGS- 119
Query: 65 YRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGK 124
Y+F P +G GLL+ +G W HR+M+ P FH +ILK +VG+ + +++K + +G+
Sbjct: 120 YKFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQ 179
Query: 125 --TFDVHDYMSGTTVDILLETAMGISRKTQ-DESGFDYAMAVMKMCDIIHQRHYKFWMRS 181
+V ++S T+D ++++A Q D + Y A+ + ++ + +
Sbjct: 180 DSPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHEN 239
Query: 182 EIVFKLTSFFKQQTKLLGIIHGLTNKVIKNKK 213
+ ++ LTS + + + H T++VI+ +K
Sbjct: 240 DTIYSLTSAGRWTHRACQLAHQHTDQVIQLRK 271
>AF208532-1|AAF76722.1| 519|Homo sapiens fatty acid
omega-hydroxylase CYP4A11 protein.
Length = 519
Score = 142 bits (345), Expect = 2e-33
Identities = 71/185 (38%), Positives = 111/185 (60%), Gaps = 4/185 (2%)
Query: 267 VGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQD 326
+ K+ L FLD+++ + + +SD +++ EVDT MFEGHDTTA+G S++L L H
Sbjct: 283 IKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPK 342
Query: 327 VQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTIST 386
Q R +E++ + GD T+ +M Y I E+LRLYPPVP I R+L+ VT
Sbjct: 343 HQERCREEIHGLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTF-P 400
Query: 387 KNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV 446
+P G V++ + LH PK + + EVF+P F P + Q H ++++PFS G R+C+
Sbjct: 401 DGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSAQ--HSHAFLPFSGGSRNCI 458
Query: 447 GRKYA 451
G+++A
Sbjct: 459 GKQFA 463
Score = 85.0 bits (201), Expect = 6e-16
Identities = 56/212 (26%), Positives = 107/212 (50%), Gaps = 6/212 (2%)
Query: 6 HVQEENLTQKLVNLALGYAQTFGNVIRVWL-GSKLIVFLVDADDIEIILNSHVHIDKATE 64
H+QE Q+L + +TF + W+ G K+ V L D D +++IL +
Sbjct: 62 HIQEFQHDQELQRIQ-ERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGS- 119
Query: 65 YRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGK 124
YRF P +G GLL+ +G W HR+M+ P FH +ILK +VG+ + +++K + +G+
Sbjct: 120 YRFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQ 179
Query: 125 --TFDVHDYMSGTTVDILLETAMGISRKTQ-DESGFDYAMAVMKMCDIIHQRHYKFWMRS 181
+V ++S T+D ++++A Q D + Y A+ + ++ + +
Sbjct: 180 DSPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHEN 239
Query: 182 EIVFKLTSFFKQQTKLLGIIHGLTNKVIKNKK 213
+ ++ LTS + + + H T++VI+ +K
Sbjct: 240 DTIYSLTSAGRWTHRACQLAHQHTDQVIQLRK 271
>BC041158-1|AAH41158.1| 455|Homo sapiens CYP4A11 protein protein.
Length = 455
Score = 134 bits (325), Expect = 5e-31
Identities = 69/177 (38%), Positives = 104/177 (58%), Gaps = 4/177 (2%)
Query: 267 VGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQD 326
+ K+ L FLD+++ + + +SD +++ EVDT MFEGHDTTA+G S++L L H
Sbjct: 283 IKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPK 342
Query: 327 VQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTIST 386
Q R +E++ + GD T+ +M Y I E+LRLYPPVP I R+L+ VT
Sbjct: 343 HQERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTF-P 400
Query: 387 KNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPR 443
+P G V++ + LH PK + +PEVF+P F P + Q H ++++PFS G R
Sbjct: 401 DGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQ--HSHAFLPFSGGSR 455
Score = 97.9 bits (233), Expect = 7e-20
Identities = 59/212 (27%), Positives = 111/212 (52%), Gaps = 6/212 (2%)
Query: 6 HVQEENLTQKLVNLALGYAQTFGNVIRVWL-GSKLIVFLVDADDIEIILNSHVHIDKATE 64
H+QE Q+L + + +TF + WL G K+ V L D D +++IL +
Sbjct: 62 HIQELQQDQELQRIQK-WVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGS- 119
Query: 65 YRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGK 124
YRF PW+G GLL+ +G W HR+M+ P FH +ILK +VG+ + +++K + +G+
Sbjct: 120 YRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQ 179
Query: 125 --TFDVHDYMSGTTVDILLETAMGISRKTQ-DESGFDYAMAVMKMCDIIHQRHYKFWMRS 181
+V ++S T+D +++ A Q D + Y A+ + +++ R + ++
Sbjct: 180 DSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQN 239
Query: 182 EIVFKLTSFFKQQTKLLGIIHGLTNKVIKNKK 213
+ ++ LTS + + + H T++VI+ +K
Sbjct: 240 DTIYSLTSAGRWTHRACQLAHQHTDQVIQLRK 271
>AL731892-4|CAH72779.1| 455|Homo sapiens cytochrome P450, family 4,
subfamily A, polypeptide 11 protein.
Length = 455
Score = 134 bits (325), Expect = 5e-31
Identities = 69/177 (38%), Positives = 104/177 (58%), Gaps = 4/177 (2%)
Query: 267 VGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQD 326
+ K+ L FLD+++ + + +SD +++ EVDT MFEGHDTTA+G S++L L H
Sbjct: 283 IKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPK 342
Query: 327 VQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTIST 386
Q R +E++ + GD T+ +M Y I E+LRLYPPVP I R+L+ VT
Sbjct: 343 HQERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTF-P 400
Query: 387 KNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPR 443
+P G V++ + LH PK + +PEVF+P F P + Q H ++++PFS G R
Sbjct: 401 DGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQ--HSHAFLPFSGGSR 455
Score = 97.9 bits (233), Expect = 7e-20
Identities = 59/212 (27%), Positives = 111/212 (52%), Gaps = 6/212 (2%)
Query: 6 HVQEENLTQKLVNLALGYAQTFGNVIRVWL-GSKLIVFLVDADDIEIILNSHVHIDKATE 64
H+QE Q+L + + +TF + WL G K+ V L D D +++IL +
Sbjct: 62 HIQELQQDQELQRIQK-WVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGS- 119
Query: 65 YRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGK 124
YRF PW+G GLL+ +G W HR+M+ P FH +ILK +VG+ + +++K + +G+
Sbjct: 120 YRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQ 179
Query: 125 --TFDVHDYMSGTTVDILLETAMGISRKTQ-DESGFDYAMAVMKMCDIIHQRHYKFWMRS 181
+V ++S T+D +++ A Q D + Y A+ + +++ R + ++
Sbjct: 180 DSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQN 239
Query: 182 EIVFKLTSFFKQQTKLLGIIHGLTNKVIKNKK 213
+ ++ LTS + + + H T++VI+ +K
Sbjct: 240 DTIYSLTSAGRWTHRACQLAHQHTDQVIQLRK 271
>M14096-1|AAA35744.1| 503|Homo sapiens protein ( Human cytochrome
P-450 nifedipine oxidase mRNA, complet cds. ).
Length = 503
Score = 132 bits (318), Expect = 4e-30
Identities = 76/236 (32%), Positives = 129/236 (54%), Gaps = 10/236 (4%)
Query: 269 EKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K R+ FL LMI+S + + +SD E+ + +F G++TT++ SF++ L H
Sbjct: 265 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ ++ +E+ + + P T+ L+M+YL+ V+ E+LRL+P + R +DV I
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
+ IP G V+I ++ LHR PKY+ +PE F P+ F +N N Y+Y PF +GPR+
Sbjct: 384 N--GMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYTYTPFGSGPRN 441
Query: 445 CVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDI--ILKRAEGFQMKVEPR 498
C+G ++A +NF + E + L+ + +L+ + +KVE R
Sbjct: 442 CIGMRFALMNMKLALIRVLQNF-SFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 496
Score = 48.0 bits (109), Expect = 8e-05
Identities = 31/126 (24%), Positives = 61/126 (48%), Gaps = 5/126 (3%)
Query: 27 FGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGPKW 84
+G V + G + ++ + D D I+ +L + T R F P ++ + I+ +W
Sbjct: 68 YGKVWGFYDGQQPVLAITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKSAISIAEDEEW 126
Query: 85 RSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLK--SEVGKTFDVHDYMSGTTVDILLE 142
+ R +++PTF LK V I Q + +V L+ +E GK + D ++D++
Sbjct: 127 KRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITS 186
Query: 143 TAMGIS 148
T+ G++
Sbjct: 187 TSFGVN 192
>M13785-1|AAA35742.1| 504|Homo sapiens protein ( Human liver
glucocorticoid-inducible cytochrome P-450 (HLp) mRNA,
complete cds. ).
Length = 504
Score = 132 bits (318), Expect = 4e-30
Identities = 77/237 (32%), Positives = 128/237 (54%), Gaps = 11/237 (4%)
Query: 269 EKKRLAFLDLMIESSQNGTNK-----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGI 323
+K R+ FL LMI+S +N +SD E+ + +F G++TT++ SF++ L
Sbjct: 265 QKHRVDFLQLMIDSHKNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELAT 324
Query: 324 HQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVT 383
H DVQ ++ +E+ + + P T+ L+M+YL+ V+ E+LRL+P + R +DV
Sbjct: 325 HPDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVE 383
Query: 384 ISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPR 443
I+ IP G V+I ++ LHR PKY+ +PE F P+ F +N N Y Y PF +GPR
Sbjct: 384 IN--GMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPR 441
Query: 444 SCVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDI--ILKRAEGFQMKVEPR 498
+C+G ++A +NF + E + L+ + +L+ + +KVE R
Sbjct: 442 NCIGMRFALMNMKLALIRVLQNF-SFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 497
Score = 44.8 bits (101), Expect = 7e-04
Identities = 29/126 (23%), Positives = 60/126 (47%), Gaps = 5/126 (3%)
Query: 27 FGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGPKW 84
+G V + G + ++ + D D I+++L + T F P ++ + I+ +W
Sbjct: 68 YGKVWGFYDGQQPVLAITDPDMIKLVLVKECY-SVFTNREPFGPVGFMKSAISIAEDEEW 126
Query: 85 RSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLK--SEVGKTFDVHDYMSGTTVDILLE 142
+ R +++PTF LK V I Q + +V L+ E GK + D ++D++
Sbjct: 127 KRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRRERETGKPVTLKDVFGAYSMDVITS 186
Query: 143 TAMGIS 148
++ G++
Sbjct: 187 SSFGVN 192
>J04449-1|AAA35747.1| 502|Homo sapiens cytochrome P450 nifedipine
oxidase protein.
Length = 502
Score = 132 bits (318), Expect = 4e-30
Identities = 76/236 (32%), Positives = 129/236 (54%), Gaps = 10/236 (4%)
Query: 269 EKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K R+ FL LMI+S + + +SD E+ + +F G++TT++ SF++ L H
Sbjct: 264 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 323
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ ++ +E+ + + P T+ L+M+YL+ V+ E+LRL+P + R +DV I
Sbjct: 324 PDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 382
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
+ IP G V+I ++ LHR PKY+ +PE F P+ F +N N Y+Y PF +GPR+
Sbjct: 383 N--GMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYTYTPFGSGPRN 440
Query: 445 CVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDI--ILKRAEGFQMKVEPR 498
C+G ++A +NF + E + L+ + +L+ + +KVE R
Sbjct: 441 CIGMRFALMNMKLALIRVLQNF-SFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 495
Score = 48.8 bits (111), Expect = 4e-05
Identities = 31/126 (24%), Positives = 61/126 (48%), Gaps = 5/126 (3%)
Query: 27 FGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGPKW 84
+G V + G + ++ + D D I+ +L + T R F P ++ + I+ +W
Sbjct: 68 YGKVCGFYDGQQPVLAITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKSAISIAEDEEW 126
Query: 85 RSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLK--SEVGKTFDVHDYMSGTTVDILLE 142
+ R +++PTF LK V I Q + +V L+ +E GK + D ++D++
Sbjct: 127 KRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITS 186
Query: 143 TAMGIS 148
T+ G++
Sbjct: 187 TSFGVN 192
>D00003-1|BAA00001.1| 504|Homo sapiens cytochrome P-450 protein.
Length = 504
Score = 132 bits (318), Expect = 4e-30
Identities = 77/237 (32%), Positives = 128/237 (54%), Gaps = 11/237 (4%)
Query: 269 EKKRLAFLDLMIESSQNGTNK-----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGI 323
+K R+ FL LMI+S +N +SD E+ + +F G++TT++ SF++ L
Sbjct: 265 QKHRVDFLQLMIDSHKNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELAT 324
Query: 324 HQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVT 383
H DVQ ++ +E+ + + P T+ L+M+YL+ V+ E+LRL+P + R +DV
Sbjct: 325 HPDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVE 383
Query: 384 ISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPR 443
I+ IP G V+I ++ LHR PKY+ +PE F P+ F +N N Y Y PF +GPR
Sbjct: 384 IN--GMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPR 441
Query: 444 SCVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDI--ILKRAEGFQMKVEPR 498
+C+G ++A +NF + E + L+ + +L+ + +KVE R
Sbjct: 442 NCIGMRFALMNMKLALIRVLQNF-SFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 497
Score = 44.8 bits (101), Expect = 7e-04
Identities = 29/126 (23%), Positives = 60/126 (47%), Gaps = 5/126 (3%)
Query: 27 FGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGPKW 84
+G V + G + ++ + D D I+++L + T F P ++ + I+ +W
Sbjct: 68 YGKVWGFYDGQQPVLAITDPDMIKLVLVKECY-SVFTNREPFGPVGFMKSAISIAEDEEW 126
Query: 85 RSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLK--SEVGKTFDVHDYMSGTTVDILLE 142
+ R +++PTF LK V I Q + +V L+ E GK + D ++D++
Sbjct: 127 KRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRRERETGKPVTLKDVFGAYSMDVITS 186
Query: 143 TAMGIS 148
++ G++
Sbjct: 187 SSFGVN 192
>M18907-1|AAA35745.1| 503|Homo sapiens protein ( Human P450 mRNA
encoding nifedipine oxidase, complete cds. ).
Length = 503
Score = 131 bits (317), Expect = 5e-30
Identities = 76/236 (32%), Positives = 128/236 (54%), Gaps = 10/236 (4%)
Query: 269 EKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K R+ FL LMI+S + + +SD E+ + +F G++TT++ SF++ L H
Sbjct: 265 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ ++ +E+ + + P T+ L+M+YL+ V+ E+LRL+P + R +DV I
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
+ IP G V+I ++ LHR PKY+ +PE F P+ F +N N Y Y PF +GPR+
Sbjct: 384 N--GMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 445 CVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDI--ILKRAEGFQMKVEPR 498
C+G ++A +NF + E + L+ + +L+ + +KVE R
Sbjct: 442 CIGMRFALMNMKLALIRVLQNF-SFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 496
Score = 48.0 bits (109), Expect = 8e-05
Identities = 31/126 (24%), Positives = 61/126 (48%), Gaps = 5/126 (3%)
Query: 27 FGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGPKW 84
+G V + G + ++ + D D I+ +L + T R F P ++ + I+ +W
Sbjct: 68 YGKVWGFYDGQQPVLAITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKSAISIAEDEEW 126
Query: 85 RSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLK--SEVGKTFDVHDYMSGTTVDILLE 142
+ R +++PTF LK V I Q + +V L+ +E GK + D ++D++
Sbjct: 127 KRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITS 186
Query: 143 TAMGIS 148
T+ G++
Sbjct: 187 TSFGVN 192
>DQ924960-1|ABI96208.1| 503|Homo sapiens cytochrome P450 family 3
subfamily A polypeptide 4 protein.
Length = 503
Score = 131 bits (317), Expect = 5e-30
Identities = 76/236 (32%), Positives = 128/236 (54%), Gaps = 10/236 (4%)
Query: 269 EKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K R+ FL LMI+S + + +SD E+ + +F G++TT++ SF++ L H
Sbjct: 265 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ ++ +E+ + + P T+ L+M+YL+ V+ E+LRL+P + R +DV I
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
+ IP G V+I ++ LHR PKY+ +PE F P+ F +N N Y Y PF +GPR+
Sbjct: 384 N--GMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 445 CVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDI--ILKRAEGFQMKVEPR 498
C+G ++A +NF + E + L+ + +L+ + +KVE R
Sbjct: 442 CIGMRFALMNMKLALIRVLQNF-SFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 496
Score = 48.0 bits (109), Expect = 8e-05
Identities = 31/126 (24%), Positives = 61/126 (48%), Gaps = 5/126 (3%)
Query: 27 FGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGPKW 84
+G V + G + ++ + D D I+ +L + T R F P ++ + I+ +W
Sbjct: 68 YGKVWGFYDGQQPVLAITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKSAISIAEDEEW 126
Query: 85 RSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLK--SEVGKTFDVHDYMSGTTVDILLE 142
+ R +++PTF LK V I Q + +V L+ +E GK + D ++D++
Sbjct: 127 KRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITS 186
Query: 143 TAMGIS 148
T+ G++
Sbjct: 187 TSFGVN 192
>DQ005611-1|AAY16980.1| 503|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 4 protein.
Length = 503
Score = 131 bits (317), Expect = 5e-30
Identities = 76/236 (32%), Positives = 128/236 (54%), Gaps = 10/236 (4%)
Query: 269 EKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K R+ FL LMI+S + + +SD E+ + +F G++TT++ SF++ L H
Sbjct: 265 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ ++ +E+ + + P T+ L+M+YL+ V+ E+LRL+P + R +DV I
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
+ IP G V+I ++ LHR PKY+ +PE F P+ F +N N Y Y PF +GPR+
Sbjct: 384 N--GMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 445 CVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDI--ILKRAEGFQMKVEPR 498
C+G ++A +NF + E + L+ + +L+ + +KVE R
Sbjct: 442 CIGMRFALMNMKLALIRVLQNF-SFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 496
Score = 48.0 bits (109), Expect = 8e-05
Identities = 31/126 (24%), Positives = 61/126 (48%), Gaps = 5/126 (3%)
Query: 27 FGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGPKW 84
+G V + G + ++ + D D I+ +L + T R F P ++ + I+ +W
Sbjct: 68 YGKVWGFYDGQQPVLAITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKSAISIAEDEEW 126
Query: 85 RSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLK--SEVGKTFDVHDYMSGTTVDILLE 142
+ R +++PTF LK V I Q + +V L+ +E GK + D ++D++
Sbjct: 127 KRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITS 186
Query: 143 TAMGIS 148
T+ G++
Sbjct: 187 TSFGVN 192
>BC101631-1|AAI01632.1| 503|Homo sapiens cytochrome P450, subfamily
IIIA, polypeptide 4 protein.
Length = 503
Score = 131 bits (317), Expect = 5e-30
Identities = 76/236 (32%), Positives = 128/236 (54%), Gaps = 10/236 (4%)
Query: 269 EKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K R+ FL LMI+S + + +SD E+ + +F G++TT++ SF++ L H
Sbjct: 265 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ ++ +E+ + + P T+ L+M+YL+ V+ E+LRL+P + R +DV I
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
+ IP G V+I ++ LHR PKY+ +PE F P+ F +N N Y Y PF +GPR+
Sbjct: 384 N--GMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 445 CVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDI--ILKRAEGFQMKVEPR 498
C+G ++A +NF + E + L+ + +L+ + +KVE R
Sbjct: 442 CIGMRFALMNMKLALIRVLQNF-SFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 496
Score = 48.0 bits (109), Expect = 8e-05
Identities = 31/126 (24%), Positives = 61/126 (48%), Gaps = 5/126 (3%)
Query: 27 FGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGPKW 84
+G V + G + ++ + D D I+ +L + T R F P ++ + I+ +W
Sbjct: 68 YGKVWGFYDGQQPVLAITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKSAISIAEDEEW 126
Query: 85 RSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLK--SEVGKTFDVHDYMSGTTVDILLE 142
+ R +++PTF LK V I Q + +V L+ +E GK + D ++D++
Sbjct: 127 KRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITS 186
Query: 143 TAMGIS 148
T+ G++
Sbjct: 187 TSFGVN 192
>BC069418-1|AAH69418.1| 503|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 4 protein.
Length = 503
Score = 131 bits (317), Expect = 5e-30
Identities = 76/236 (32%), Positives = 128/236 (54%), Gaps = 10/236 (4%)
Query: 269 EKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K R+ FL LMI+S + + +SD E+ + +F G++TT++ SF++ L H
Sbjct: 265 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ ++ +E+ + + P T+ L+M+YL+ V+ E+LRL+P + R +DV I
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
+ IP G V+I ++ LHR PKY+ +PE F P+ F +N N Y Y PF +GPR+
Sbjct: 384 N--GMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 445 CVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDI--ILKRAEGFQMKVEPR 498
C+G ++A +NF + E + L+ + +L+ + +KVE R
Sbjct: 442 CIGMRFALMNMKLALIRVLQNF-SFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 496
Score = 48.0 bits (109), Expect = 8e-05
Identities = 31/126 (24%), Positives = 61/126 (48%), Gaps = 5/126 (3%)
Query: 27 FGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGPKW 84
+G V + G + ++ + D D I+ +L + T R F P ++ + I+ +W
Sbjct: 68 YGKVWGFYDGQQPVLAITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKSAISIAEDEEW 126
Query: 85 RSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLK--SEVGKTFDVHDYMSGTTVDILLE 142
+ R +++PTF LK V I Q + +V L+ +E GK + D ++D++
Sbjct: 127 KRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITS 186
Query: 143 TAMGIS 148
T+ G++
Sbjct: 187 TSFGVN 192
>AJ563377-1|CAD91345.1| 353|Homo sapiens cytochrome P450 protein.
Length = 353
Score = 131 bits (317), Expect = 5e-30
Identities = 76/236 (32%), Positives = 128/236 (54%), Gaps = 10/236 (4%)
Query: 269 EKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K R+ FL LMI+S + + +SD E+ + +F G++TT++ SF++ L H
Sbjct: 115 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 174
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ ++ +E+ + + P T+ L+M+YL+ V+ E+LRL+P + R +DV I
Sbjct: 175 PDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 233
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
+ IP G V+I ++ LHR PKY+ +PE F P+ F +N N Y Y PF +GPR+
Sbjct: 234 N--GMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 291
Query: 445 CVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDI--ILKRAEGFQMKVEPR 498
C+G ++A +NF + E + L+ + +L+ + +KVE R
Sbjct: 292 CIGMRFALMNMKLALIRVLQNF-SFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 346
>AJ563376-2|CAD91645.1| 430|Homo sapiens cytochrome P450 protein.
Length = 430
Score = 131 bits (317), Expect = 5e-30
Identities = 76/236 (32%), Positives = 128/236 (54%), Gaps = 10/236 (4%)
Query: 269 EKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K R+ FL LMI+S + + +SD E+ + +F G++TT++ SF++ L H
Sbjct: 192 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 251
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ ++ +E+ + + P T+ L+M+YL+ V+ E+LRL+P + R +DV I
Sbjct: 252 PDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 310
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
+ IP G V+I ++ LHR PKY+ +PE F P+ F +N N Y Y PF +GPR+
Sbjct: 311 N--GMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 368
Query: 445 CVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDI--ILKRAEGFQMKVEPR 498
C+G ++A +NF + E + L+ + +L+ + +KVE R
Sbjct: 369 CIGMRFALMNMKLALIRVLQNF-SFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 423
Score = 46.0 bits (104), Expect = 3e-04
Identities = 29/117 (24%), Positives = 57/117 (48%), Gaps = 5/117 (4%)
Query: 36 GSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGPKWRSHRKMIAP 93
G + ++ + D D I+ +L + T R F P ++ + I+ +W+ R +++P
Sbjct: 4 GQQPVLAITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSP 62
Query: 94 TFHINILKSFVGIFNQNSNNVVEKLK--SEVGKTFDVHDYMSGTTVDILLETAMGIS 148
TF LK V I Q + +V L+ +E GK + D ++D++ T+ G++
Sbjct: 63 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVN 119
>AJ563375-1|CAD91343.1| 503|Homo sapiens cytochrome P450 protein.
Length = 503
Score = 131 bits (317), Expect = 5e-30
Identities = 76/236 (32%), Positives = 128/236 (54%), Gaps = 10/236 (4%)
Query: 269 EKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K R+ FL LMI+S + + +SD E+ + +F G++TT++ SF++ L H
Sbjct: 265 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ ++ +E+ + + P T+ L+M+YL+ V+ E+LRL+P + R +DV I
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
+ IP G V+I ++ LHR PKY+ +PE F P+ F +N N Y Y PF +GPR+
Sbjct: 384 N--GMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 445 CVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDI--ILKRAEGFQMKVEPR 498
C+G ++A +NF + E + L+ + +L+ + +KVE R
Sbjct: 442 CIGMRFALMNMKLALIRVLQNF-SFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 496
Score = 48.0 bits (109), Expect = 8e-05
Identities = 31/126 (24%), Positives = 61/126 (48%), Gaps = 5/126 (3%)
Query: 27 FGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGPKW 84
+G V + G + ++ + D D I+ +L + T R F P ++ + I+ +W
Sbjct: 68 YGKVWGFYDGQQPVLAITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKSAISIAEDEEW 126
Query: 85 RSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLK--SEVGKTFDVHDYMSGTTVDILLE 142
+ R +++PTF LK V I Q + +V L+ +E GK + D ++D++
Sbjct: 127 KRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITS 186
Query: 143 TAMGIS 148
T+ G++
Sbjct: 187 TSFGVN 192
>AF280107-2|AAG32290.1| 503|Homo sapiens cytochrome P450
polypeptide 4 protein.
Length = 503
Score = 131 bits (317), Expect = 5e-30
Identities = 76/236 (32%), Positives = 128/236 (54%), Gaps = 10/236 (4%)
Query: 269 EKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K R+ FL LMI+S + + +SD E+ + +F G++TT++ SF++ L H
Sbjct: 265 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ ++ +E+ + + P T+ L+M+YL+ V+ E+LRL+P + R +DV I
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
+ IP G V+I ++ LHR PKY+ +PE F P+ F +N N Y Y PF +GPR+
Sbjct: 384 N--GMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 445 CVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDI--ILKRAEGFQMKVEPR 498
C+G ++A +NF + E + L+ + +L+ + +KVE R
Sbjct: 442 CIGMRFALMNMKLALIRVLQNF-SFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 496
Score = 48.0 bits (109), Expect = 8e-05
Identities = 31/126 (24%), Positives = 61/126 (48%), Gaps = 5/126 (3%)
Query: 27 FGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGPKW 84
+G V + G + ++ + D D I+ +L + T R F P ++ + I+ +W
Sbjct: 68 YGKVWGFYDGQQPVLAITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKSAISIAEDEEW 126
Query: 85 RSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLK--SEVGKTFDVHDYMSGTTVDILLE 142
+ R +++PTF LK V I Q + +V L+ +E GK + D ++D++
Sbjct: 127 KRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITS 186
Query: 143 TAMGIS 148
T+ G++
Sbjct: 187 TSFGVN 192
>AF209389-1|AAF21034.1| 503|Homo sapiens cytochrome P450 IIIA4
protein.
Length = 503
Score = 131 bits (317), Expect = 5e-30
Identities = 76/236 (32%), Positives = 128/236 (54%), Gaps = 10/236 (4%)
Query: 269 EKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K R+ FL LMI+S + + +SD E+ + +F G++TT++ SF++ L H
Sbjct: 265 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ ++ +E+ + + P T+ L+M+YL+ V+ E+LRL+P + R +DV I
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
+ IP G V+I ++ LHR PKY+ +PE F P+ F +N N Y Y PF +GPR+
Sbjct: 384 N--GMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 445 CVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDI--ILKRAEGFQMKVEPR 498
C+G ++A +NF + E + L+ + +L+ + +KVE R
Sbjct: 442 CIGMRFALMNMKLALIRVLQNF-SFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 496
Score = 48.0 bits (109), Expect = 8e-05
Identities = 31/126 (24%), Positives = 61/126 (48%), Gaps = 5/126 (3%)
Query: 27 FGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGPKW 84
+G V + G + ++ + D D I+ +L + T R F P ++ + I+ +W
Sbjct: 68 YGKVWGFYDGQQPVLAITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKSAISIAEDEEW 126
Query: 85 RSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLK--SEVGKTFDVHDYMSGTTVDILLE 142
+ R +++PTF LK V I Q + +V L+ +E GK + D ++D++
Sbjct: 127 KRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITS 186
Query: 143 TAMGIS 148
T+ G++
Sbjct: 187 TSFGVN 192
>AL135960-11|CAI19738.1| 455|Homo sapiens cytochrome P450, family
4, subfamily A, polypeptide 22 protein.
Length = 455
Score = 131 bits (316), Expect = 6e-30
Identities = 68/177 (38%), Positives = 103/177 (58%), Gaps = 4/177 (2%)
Query: 267 VGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQD 326
+ K+ L FLD+++ + + +SD +++ EVDT MFEGHDTTA+G S++L L H
Sbjct: 283 IKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPK 342
Query: 327 VQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTIST 386
Q R +E++ + GD T+ +M Y I E+LRLYPPVP I R+L+ VT
Sbjct: 343 HQERCREEIHGLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTF-P 400
Query: 387 KNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPR 443
+P G V++ + LH PK + + EVF+P F P + Q H ++++PFS G R
Sbjct: 401 DGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSAQ--HSHAFLPFSGGSR 455
Score = 83.8 bits (198), Expect = 1e-15
Identities = 55/212 (25%), Positives = 107/212 (50%), Gaps = 6/212 (2%)
Query: 6 HVQEENLTQKLVNLALGYAQTFGNVIRVWL-GSKLIVFLVDADDIEIILNSHVHIDKATE 64
H+QE Q+L + +TF + W+ G K+ V L D D +++IL +
Sbjct: 62 HIQEFQHDQELQRIQ-ERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGS- 119
Query: 65 YRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGK 124
Y+F P +G GLL+ +G W HR+M+ P FH +ILK +VG+ + +++K + +G+
Sbjct: 120 YKFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQ 179
Query: 125 --TFDVHDYMSGTTVDILLETAMGISRKTQ-DESGFDYAMAVMKMCDIIHQRHYKFWMRS 181
+V ++S T+D ++++A Q D + Y A+ + ++ + +
Sbjct: 180 DSPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHEN 239
Query: 182 EIVFKLTSFFKQQTKLLGIIHGLTNKVIKNKK 213
+ ++ LTS + + + H T++VI+ +K
Sbjct: 240 DTIYSLTSAGRWTHRACQLAHQHTDQVIQLRK 271
>X12387-1|CAA30944.1| 503|Homo sapiens protein ( Human mRNA for
cytochrome P-450 (cyp3 locus). ).
Length = 503
Score = 130 bits (315), Expect = 9e-30
Identities = 76/236 (32%), Positives = 128/236 (54%), Gaps = 10/236 (4%)
Query: 269 EKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K R+ FL LMI+S + + +SD E+ + +F G++TT++ SF++ L H
Sbjct: 265 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ ++ +E+ + + P T+ L+M+YL+ V+ E+LRL+P + R +DV I
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
+ IP G V+I ++ LHR PKY+ +PE F P+ F +N N Y Y PF +GPR+
Sbjct: 384 N--GMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 445 CVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDI--ILKRAEGFQMKVEPR 498
C+G ++A +NF + E + L+ + +L+ + +KVE R
Sbjct: 442 CIGMRFALMNMKLALIRVLQNF-SFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 496
Score = 48.0 bits (109), Expect = 8e-05
Identities = 31/126 (24%), Positives = 61/126 (48%), Gaps = 5/126 (3%)
Query: 27 FGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGPKW 84
+G V + G + ++ + D D I+ +L + T R F P ++ + I+ +W
Sbjct: 68 YGKVWGFYDGQQPVLAITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKSAISIAEDEEW 126
Query: 85 RSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLK--SEVGKTFDVHDYMSGTTVDILLE 142
+ R +++PTF LK V I Q + +V L+ +E GK + D ++D++
Sbjct: 127 KRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITS 186
Query: 143 TAMGIS 148
T+ G++
Sbjct: 187 TSFGVN 192
>D00408-1|BAA00310.1| 503|Homo sapiens cytochrome P-450 HFLa
protein.
Length = 503
Score = 130 bits (313), Expect = 1e-29
Identities = 70/202 (34%), Positives = 114/202 (56%), Gaps = 7/202 (3%)
Query: 269 EKKRLAFLDLMIESSQNG---TNK-ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K R+ FL LMI+S + T+K +SD E+ + +F G++TT++ SF++ L H
Sbjct: 265 QKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATH 324
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ +V E+ + + P T+ L+++YL+ V+ E+LRL+P + R +DV I
Sbjct: 325 PDVQQKVQKEIDTVLPNK-APPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEI 383
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
+ IP G V+I +++LH PKY+ +PE F P+ F +N N Y Y PF +GPR+
Sbjct: 384 N--GMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 445 CVGRKYAXXXXXXXXXXXXRNF 466
C+G ++A +NF
Sbjct: 442 CIGMRFALVNMKLALVRVLQNF 463
Score = 41.9 bits (94), Expect = 0.005
Identities = 28/110 (25%), Positives = 52/110 (47%), Gaps = 5/110 (4%)
Query: 43 LVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGPKWRSHRKMIAPTFHINIL 100
+ D D I+ +L + T R F P ++ + I+ +W+ R +++PTF L
Sbjct: 84 ITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKL 142
Query: 101 KSFVGIFNQNSNNVVEKLK--SEVGKTFDVHDYMSGTTVDILLETAMGIS 148
K V I Q + +V L+ +E GK + ++D++ T+ G+S
Sbjct: 143 KEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVS 192
>BC067436-1|AAH67436.1| 503|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 7 protein.
Length = 503
Score = 130 bits (313), Expect = 1e-29
Identities = 70/202 (34%), Positives = 114/202 (56%), Gaps = 7/202 (3%)
Query: 269 EKKRLAFLDLMIESSQNG---TNK-ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K R+ FL LMI+S + T+K +SD E+ + +F G++TT++ SF++ L H
Sbjct: 265 QKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATH 324
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ +V E+ + + P T+ L+++YL+ V+ E+LRL+P + R +DV I
Sbjct: 325 PDVQQKVQKEIDTVLPNK-APPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEI 383
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
+ IP G V+I +++LH PKY+ +PE F P+ F +N N Y Y PF +GPR+
Sbjct: 384 N--GMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 445 CVGRKYAXXXXXXXXXXXXRNF 466
C+G ++A +NF
Sbjct: 442 CIGMRFALVNMKLALVRVLQNF 463
Score = 41.9 bits (94), Expect = 0.005
Identities = 28/110 (25%), Positives = 52/110 (47%), Gaps = 5/110 (4%)
Query: 43 LVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGPKWRSHRKMIAPTFHINIL 100
+ D D I+ +L + T R F P ++ + I+ +W+ R +++PTF L
Sbjct: 84 ITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKL 142
Query: 101 KSFVGIFNQNSNNVVEKLK--SEVGKTFDVHDYMSGTTVDILLETAMGIS 148
K V I Q + +V L+ +E GK + ++D++ T+ G+S
Sbjct: 143 KEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVS 192
>AF315325-1|AAG48618.1| 535|Homo sapiens cytochrome P450 variant
3A7 protein.
Length = 535
Score = 130 bits (313), Expect = 1e-29
Identities = 70/202 (34%), Positives = 114/202 (56%), Gaps = 7/202 (3%)
Query: 269 EKKRLAFLDLMIESSQNG---TNK-ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K R+ FL LMI+S + T+K +SD E+ + +F G++TT++ SF++ L H
Sbjct: 265 QKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATH 324
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ +V E+ + + P T+ L+++YL+ V+ E+LRL+P + R +DV I
Sbjct: 325 PDVQQKVQKEIDTVLPNK-APPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEI 383
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
+ IP G V+I +++LH PKY+ +PE F P+ F +N N Y Y PF +GPR+
Sbjct: 384 N--GMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 445 CVGRKYAXXXXXXXXXXXXRNF 466
C+G ++A +NF
Sbjct: 442 CIGMRFALVNMKLALVRVLQNF 463
Score = 41.9 bits (94), Expect = 0.005
Identities = 28/110 (25%), Positives = 52/110 (47%), Gaps = 5/110 (4%)
Query: 43 LVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGPKWRSHRKMIAPTFHINIL 100
+ D D I+ +L + T R F P ++ + I+ +W+ R +++PTF L
Sbjct: 84 ITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKL 142
Query: 101 KSFVGIFNQNSNNVVEKLK--SEVGKTFDVHDYMSGTTVDILLETAMGIS 148
K V I Q + +V L+ +E GK + ++D++ T+ G+S
Sbjct: 143 KEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVS 192
>AF280107-3|AAG32289.1| 503|Homo sapiens cytochrome P450
polypeptide 7 protein.
Length = 503
Score = 130 bits (313), Expect = 1e-29
Identities = 70/202 (34%), Positives = 114/202 (56%), Gaps = 7/202 (3%)
Query: 269 EKKRLAFLDLMIESSQNG---TNK-ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K R+ FL LMI+S + T+K +SD E+ + +F G++TT++ SF++ L H
Sbjct: 265 QKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATH 324
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ +V E+ + + P T+ L+++YL+ V+ E+LRL+P + R +DV I
Sbjct: 325 PDVQQKVQKEIDTVLPNK-APPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEI 383
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
+ IP G V+I +++LH PKY+ +PE F P+ F +N N Y Y PF +GPR+
Sbjct: 384 N--GMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 445 CVGRKYAXXXXXXXXXXXXRNF 466
C+G ++A +NF
Sbjct: 442 CIGMRFALVNMKLALVRVLQNF 463
Score = 41.9 bits (94), Expect = 0.005
Identities = 28/110 (25%), Positives = 52/110 (47%), Gaps = 5/110 (4%)
Query: 43 LVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGPKWRSHRKMIAPTFHINIL 100
+ D D I+ +L + T R F P ++ + I+ +W+ R +++PTF L
Sbjct: 84 ITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKL 142
Query: 101 KSFVGIFNQNSNNVVEKLK--SEVGKTFDVHDYMSGTTVDILLETAMGIS 148
K V I Q + +V L+ +E GK + ++D++ T+ G+S
Sbjct: 143 KEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVS 192
>AF182273-1|AAF13598.1| 503|Homo sapiens cytochrome P450-3A4
protein.
Length = 503
Score = 129 bits (312), Expect = 2e-29
Identities = 76/236 (32%), Positives = 127/236 (53%), Gaps = 10/236 (4%)
Query: 269 EKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K R+ FL LMI+S + + +SD E+ + +F G +TT++ SF++ L H
Sbjct: 265 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGCETTSSVLSFIMYELATH 324
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ ++ +E+ + + P T+ L+M+YL+ V+ E+LRL+P + R +DV I
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
+ IP G V+I ++ LHR PKY+ +PE F P+ F +N N Y Y PF +GPR+
Sbjct: 384 N--GMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 445 CVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDI--ILKRAEGFQMKVEPR 498
C+G ++A +NF + E + L+ + +L+ + +KVE R
Sbjct: 442 CIGMRFALMNMKLALIRVLQNF-SFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 496
Score = 48.0 bits (109), Expect = 8e-05
Identities = 31/126 (24%), Positives = 61/126 (48%), Gaps = 5/126 (3%)
Query: 27 FGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGPKW 84
+G V + G + ++ + D D I+ +L + T R F P ++ + I+ +W
Sbjct: 68 YGKVWGFYDGQQPVLAITDPDMIKTVLVKECY-SVFTNRRPFGPVGFMKSAISIAEDEEW 126
Query: 85 RSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLK--SEVGKTFDVHDYMSGTTVDILLE 142
+ R +++PTF LK V I Q + +V L+ +E GK + D ++D++
Sbjct: 127 KRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITS 186
Query: 143 TAMGIS 148
T+ G++
Sbjct: 187 TSFGVN 192
>AY390424-1|AAQ92352.1| 503|Homo sapiens cytochrome P450 CYP3A43.3
protein.
Length = 503
Score = 128 bits (310), Expect = 3e-29
Identities = 66/202 (32%), Positives = 109/202 (53%), Gaps = 7/202 (3%)
Query: 269 EKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K R+ F MI+S + K +SD E+ + I+F +DTT+ F++ L H
Sbjct: 265 QKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATH 324
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ ++ +E+ + + P T+ ++M+YL+ V+ E+LRL+P V + R +D+ I
Sbjct: 325 PDVQQKLQEEIDAVLANK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI 383
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
+ IP G V++ + LH PKY+ +PE F P+ F +N + Y YIPF AGPR+
Sbjct: 384 N--GVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRN 441
Query: 445 CVGRKYAXXXXXXXXXXXXRNF 466
C+G ++A +NF
Sbjct: 442 CIGMRFALTNIKLAVIRALQNF 463
Score = 40.7 bits (91), Expect = 0.012
Identities = 27/128 (21%), Positives = 60/128 (46%), Gaps = 5/128 (3%)
Query: 25 QTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGP 82
+ +G + ++ G + ++ ++D D I+ +L + T P +L L +
Sbjct: 66 EKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECY-SVFTNQMPLGPMGFLKSALSFAEDE 124
Query: 83 KWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEV--GKTFDVHDYMSGTTVDIL 140
+W+ R +++P F K V I +Q + +V L+ E K+ ++ D+ T+D++
Sbjct: 125 EWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184
Query: 141 LETAMGIS 148
T G++
Sbjct: 185 TGTLFGVN 192
>BC100981-1|AAI00982.1| 393|Homo sapiens CYP3A43 protein protein.
Length = 393
Score = 128 bits (308), Expect = 6e-29
Identities = 66/202 (32%), Positives = 109/202 (53%), Gaps = 7/202 (3%)
Query: 269 EKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K R+ F MI+S + K +SD E+ + I+F +DTT+ F++ L H
Sbjct: 155 QKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATH 214
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ ++ +E+ + + P T+ ++M+YL+ V+ E+LRL+P V + R +D+ I
Sbjct: 215 PDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI 273
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
+ IP G V++ + LH PKY+ +PE F P+ F +N + Y YIPF AGPR+
Sbjct: 274 N--GVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRN 331
Query: 445 CVGRKYAXXXXXXXXXXXXRNF 466
C+G ++A +NF
Sbjct: 332 CIGMRFALTNIKLAVIRALQNF 353
>AY390425-1|AAQ92353.1| 503|Homo sapiens cytochrome P450 CYP3A43.1
protein.
Length = 503
Score = 128 bits (308), Expect = 6e-29
Identities = 66/202 (32%), Positives = 109/202 (53%), Gaps = 7/202 (3%)
Query: 269 EKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K R+ F MI+S + K +SD E+ + I+F +DTT+ F++ L H
Sbjct: 265 QKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATH 324
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ ++ +E+ + + P T+ ++M+YL+ V+ E+LRL+P V + R +D+ I
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI 383
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
+ IP G V++ + LH PKY+ +PE F P+ F +N + Y YIPF AGPR+
Sbjct: 384 N--GVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRN 441
Query: 445 CVGRKYAXXXXXXXXXXXXRNF 466
C+G ++A +NF
Sbjct: 442 CIGMRFALTNIKLAVIRALQNF 463
Score = 40.7 bits (91), Expect = 0.012
Identities = 27/128 (21%), Positives = 60/128 (46%), Gaps = 5/128 (3%)
Query: 25 QTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGP 82
+ +G + ++ G + ++ ++D D I+ +L + T P +L L +
Sbjct: 66 EKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECY-SVFTNQMPLGPMGFLKSALSFAEDE 124
Query: 83 KWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEV--GKTFDVHDYMSGTTVDIL 140
+W+ R +++P F K V I +Q + +V L+ E K+ ++ D+ T+D++
Sbjct: 125 EWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184
Query: 141 LETAMGIS 148
T G++
Sbjct: 185 TGTLFGVN 192
>AF337813-1|AAK38841.1| 503|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 503
Score = 128 bits (308), Expect = 6e-29
Identities = 66/202 (32%), Positives = 109/202 (53%), Gaps = 7/202 (3%)
Query: 269 EKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K R+ F MI+S + K +SD E+ + I+F +DTT+ F++ L H
Sbjct: 265 QKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATH 324
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ ++ +E+ + + P T+ ++M+YL+ V+ E+LRL+P V + R +D+ I
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI 383
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
+ IP G V++ + LH PKY+ +PE F P+ F +N + Y YIPF AGPR+
Sbjct: 384 N--GVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRN 441
Query: 445 CVGRKYAXXXXXXXXXXXXRNF 466
C+G ++A +NF
Sbjct: 442 CIGMRFALTNIKLAVIRALQNF 463
Score = 40.7 bits (91), Expect = 0.012
Identities = 27/128 (21%), Positives = 60/128 (46%), Gaps = 5/128 (3%)
Query: 25 QTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGP 82
+ +G + ++ G + ++ ++D D I+ +L + T P +L L +
Sbjct: 66 EKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECY-SVFTNQMPLGPMGFLKSALSFAEDE 124
Query: 83 KWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEV--GKTFDVHDYMSGTTVDIL 140
+W+ R +++P F K V I +Q + +V L+ E K+ ++ D+ T+D++
Sbjct: 125 EWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184
Query: 141 LETAMGIS 148
T G++
Sbjct: 185 TGTLFGVN 192
>AF319634-1|AAK00325.1| 503|Homo sapiens cytochrome P450 CYP3A43
protein.
Length = 503
Score = 128 bits (308), Expect = 6e-29
Identities = 66/202 (32%), Positives = 109/202 (53%), Gaps = 7/202 (3%)
Query: 269 EKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K R+ F MI+S + K +SD E+ + I+F +DTT+ F++ L H
Sbjct: 265 QKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATH 324
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ ++ +E+ + + P T+ ++M+YL+ V+ E+LRL+P V + R +D+ I
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI 383
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
+ IP G V++ + LH PKY+ +PE F P+ F +N + Y YIPF AGPR+
Sbjct: 384 N--GVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRN 441
Query: 445 CVGRKYAXXXXXXXXXXXXRNF 466
C+G ++A +NF
Sbjct: 442 CIGMRFALTNIKLAVIRALQNF 463
Score = 40.7 bits (91), Expect = 0.012
Identities = 27/128 (21%), Positives = 60/128 (46%), Gaps = 5/128 (3%)
Query: 25 QTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGP 82
+ +G + ++ G + ++ ++D D I+ +L + T P +L L +
Sbjct: 66 EKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECY-SVFTNQMPLGPMGFLKSALSFAEDE 124
Query: 83 KWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEV--GKTFDVHDYMSGTTVDIL 140
+W+ R +++P F K V I +Q + +V L+ E K+ ++ D+ T+D++
Sbjct: 125 EWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184
Query: 141 LETAMGIS 148
T G++
Sbjct: 185 TGTLFGVN 192
>AF280108-1|AAG33009.1| 503|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 503
Score = 128 bits (308), Expect = 6e-29
Identities = 66/202 (32%), Positives = 109/202 (53%), Gaps = 7/202 (3%)
Query: 269 EKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K R+ F MI+S + K +SD E+ + I+F +DTT+ F++ L H
Sbjct: 265 QKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATH 324
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ ++ +E+ + + P T+ ++M+YL+ V+ E+LRL+P V + R +D+ I
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI 383
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
+ IP G V++ + LH PKY+ +PE F P+ F +N + Y YIPF AGPR+
Sbjct: 384 N--GVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRN 441
Query: 445 CVGRKYAXXXXXXXXXXXXRNF 466
C+G ++A +NF
Sbjct: 442 CIGMRFALTNIKLAVIRALQNF 463
Score = 40.7 bits (91), Expect = 0.012
Identities = 27/128 (21%), Positives = 60/128 (46%), Gaps = 5/128 (3%)
Query: 25 QTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGP 82
+ +G + ++ G + ++ ++D D I+ +L + T P +L L +
Sbjct: 66 EKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECY-SVFTNQMPLGPMGFLKSALSFAEDE 124
Query: 83 KWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEV--GKTFDVHDYMSGTTVDIL 140
+W+ R +++P F K V I +Q + +V L+ E K+ ++ D+ T+D++
Sbjct: 125 EWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184
Query: 141 LETAMGIS 148
T G++
Sbjct: 185 TGTLFGVN 192
>AC011904-4|AAS07395.1| 503|Homo sapiens unknown protein.
Length = 503
Score = 128 bits (308), Expect = 6e-29
Identities = 66/202 (32%), Positives = 109/202 (53%), Gaps = 7/202 (3%)
Query: 269 EKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K R+ F MI+S + K +SD E+ + I+F +DTT+ F++ L H
Sbjct: 265 QKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATH 324
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ ++ +E+ + + P T+ ++M+YL+ V+ E+LRL+P V + R +D+ I
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI 383
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
+ IP G V++ + LH PKY+ +PE F P+ F +N + Y YIPF AGPR+
Sbjct: 384 N--GVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRN 441
Query: 445 CVGRKYAXXXXXXXXXXXXRNF 466
C+G ++A +NF
Sbjct: 442 CIGMRFALTNIKLAVIRALQNF 463
Score = 40.7 bits (91), Expect = 0.012
Identities = 27/128 (21%), Positives = 60/128 (46%), Gaps = 5/128 (3%)
Query: 25 QTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGP 82
+ +G + ++ G + ++ ++D D I+ +L + T P +L L +
Sbjct: 66 EKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECY-SVFTNQMPLGPMGFLKSALSFAEDE 124
Query: 83 KWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEV--GKTFDVHDYMSGTTVDIL 140
+W+ R +++P F K V I +Q + +V L+ E K+ ++ D+ T+D++
Sbjct: 125 EWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184
Query: 141 LETAMGIS 148
T G++
Sbjct: 185 TGTLFGVN 192
>J04813-1|AAA02993.1| 502|Homo sapiens cytochrome P450 PCN3
protein.
Length = 502
Score = 124 bits (299), Expect = 7e-28
Identities = 76/236 (32%), Positives = 124/236 (52%), Gaps = 11/236 (4%)
Query: 269 EKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K RL FL LMI+S + + +SD E+ + +F G++TT++ SF L L H
Sbjct: 265 QKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATH 324
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ ++ E+ + + P T+ ++M+YL+ V+ E+LRL+P + R +DV I
Sbjct: 325 PDVQQKLQKEIDAVLPNK-APPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI 383
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
+ IP G+ VVI T+ LH PKY+ +PE F P+ F + + Y Y PF GPR+
Sbjct: 384 N--GVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF-SKKKDSIDPYIYTPFGTGPRN 440
Query: 445 CVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDI--ILKRAEGFQMKVEPR 498
C+G ++A +NF + E + L+ D +L+ + +KV+ R
Sbjct: 441 CIGMRFALMNMKLALIRVLQNF-SFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSR 495
Score = 39.9 bits (89), Expect = 0.021
Identities = 27/126 (21%), Positives = 57/126 (45%), Gaps = 5/126 (3%)
Query: 27 FGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGPKW 84
+G + + G ++ + D D I +L + T R P ++ + ++ +W
Sbjct: 68 YGKMWGTYEGQLPVLAITDPDVIRTVLVKECY-SVFTNRRSLGPVGFMKSAISLAEDEEW 126
Query: 85 RSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLK--SEVGKTFDVHDYMSGTTVDILLE 142
+ R +++PTF LK I Q + +V L+ +E GK + D ++D++
Sbjct: 127 KRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITG 186
Query: 143 TAMGIS 148
T+ G++
Sbjct: 187 TSFGVN 192
>BC033862-1|AAH33862.1| 502|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 5 protein.
Length = 502
Score = 124 bits (299), Expect = 7e-28
Identities = 76/236 (32%), Positives = 124/236 (52%), Gaps = 11/236 (4%)
Query: 269 EKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K RL FL LMI+S + + +SD E+ + +F G++TT++ SF L L H
Sbjct: 265 QKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATH 324
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ ++ E+ + + P T+ ++M+YL+ V+ E+LRL+P + R +DV I
Sbjct: 325 PDVQQKLQKEIDAVLPNK-APPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI 383
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
+ IP G+ VVI T+ LH PKY+ +PE F P+ F + + Y Y PF GPR+
Sbjct: 384 N--GVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF-SKKKDSIDPYIYTPFGTGPRN 440
Query: 445 CVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDI--ILKRAEGFQMKVEPR 498
C+G ++A +NF + E + L+ D +L+ + +KV+ R
Sbjct: 441 CIGMRFALMNMKLALIRVLQNF-SFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSR 495
Score = 39.9 bits (89), Expect = 0.021
Identities = 27/126 (21%), Positives = 57/126 (45%), Gaps = 5/126 (3%)
Query: 27 FGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGPKW 84
+G + + G ++ + D D I +L + T R P ++ + ++ +W
Sbjct: 68 YGKMWGTYEGQLPVLAITDPDVIRTVLVKECY-SVFTNRRSLGPVGFMKSAISLAEDEEW 126
Query: 85 RSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLK--SEVGKTFDVHDYMSGTTVDILLE 142
+ R +++PTF LK I Q + +V L+ +E GK + D ++D++
Sbjct: 127 KRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITG 186
Query: 143 TAMGIS 148
T+ G++
Sbjct: 187 TSFGVN 192
>AC005020-1|AAS02016.1| 502|Homo sapiens unknown protein.
Length = 502
Score = 124 bits (299), Expect = 7e-28
Identities = 76/236 (32%), Positives = 124/236 (52%), Gaps = 11/236 (4%)
Query: 269 EKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K RL FL LMI+S + + +SD E+ + +F G++TT++ SF L L H
Sbjct: 265 QKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATH 324
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ ++ E+ + + P T+ ++M+YL+ V+ E+LRL+P + R +DV I
Sbjct: 325 PDVQQKLQKEIDAVLPNK-APPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI 383
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
+ IP G+ VVI T+ LH PKY+ +PE F P+ F + + Y Y PF GPR+
Sbjct: 384 N--GVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF-SKKKDSIDPYIYTPFGTGPRN 440
Query: 445 CVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDI--ILKRAEGFQMKVEPR 498
C+G ++A +NF + E + L+ D +L+ + +KV+ R
Sbjct: 441 CIGMRFALMNMKLALIRVLQNF-SFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSR 495
Score = 39.9 bits (89), Expect = 0.021
Identities = 27/126 (21%), Positives = 57/126 (45%), Gaps = 5/126 (3%)
Query: 27 FGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGPKW 84
+G + + G ++ + D D I +L + T R P ++ + ++ +W
Sbjct: 68 YGKMWGTYEGQLPVLAITDPDVIRTVLVKECY-SVFTNRRSLGPVGFMKSAISLAEDEEW 126
Query: 85 RSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLK--SEVGKTFDVHDYMSGTTVDILLE 142
+ R +++PTF LK I Q + +V L+ +E GK + D ++D++
Sbjct: 127 KRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITG 186
Query: 143 TAMGIS 148
T+ G++
Sbjct: 187 TSFGVN 192
>AF280109-1|AAG33010.1| 504|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 504
Score = 124 bits (298), Expect = 1e-27
Identities = 66/203 (32%), Positives = 110/203 (54%), Gaps = 8/203 (3%)
Query: 269 EKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K R+ F MI+S + K +SD E+ + I+F +DTT+ F++ L H
Sbjct: 265 QKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATH 324
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ ++ +E+ + + P T+ ++M+YL+ V+ E+LRL+P V + R +D+ I
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI 383
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDN-FLPENTQNRHYYSYIPFSAGPR 443
+ IP G V++ + LH PKY+ +PE F P++ F +N + Y YIPF AGPR
Sbjct: 384 N--GVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGPR 441
Query: 444 SCVGRKYAXXXXXXXXXXXXRNF 466
+C+G ++A +NF
Sbjct: 442 NCIGMRFALTNIKLAVIRALQNF 464
Score = 40.7 bits (91), Expect = 0.012
Identities = 27/128 (21%), Positives = 60/128 (46%), Gaps = 5/128 (3%)
Query: 25 QTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGP 82
+ +G + ++ G + ++ ++D D I+ +L + T P +L L +
Sbjct: 66 EKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECY-SVFTNQMPLGPMGFLKSALSFAEDE 124
Query: 83 KWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEV--GKTFDVHDYMSGTTVDIL 140
+W+ R +++P F K V I +Q + +V L+ E K+ ++ D+ T+D++
Sbjct: 125 EWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184
Query: 141 LETAMGIS 148
T G++
Sbjct: 185 TGTLFGVN 192
>AC011904-5|AAS07394.1| 504|Homo sapiens unknown protein.
Length = 504
Score = 124 bits (298), Expect = 1e-27
Identities = 66/203 (32%), Positives = 110/203 (54%), Gaps = 8/203 (3%)
Query: 269 EKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K R+ F MI+S + K +SD E+ + I+F +DTT+ F++ L H
Sbjct: 265 QKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATH 324
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ ++ +E+ + + P T+ ++M+YL+ V+ E+LRL+P V + R +D+ I
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI 383
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDN-FLPENTQNRHYYSYIPFSAGPR 443
+ IP G V++ + LH PKY+ +PE F P++ F +N + Y YIPF AGPR
Sbjct: 384 N--GVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGPR 441
Query: 444 SCVGRKYAXXXXXXXXXXXXRNF 466
+C+G ++A +NF
Sbjct: 442 NCIGMRFALTNIKLAVIRALQNF 464
Score = 40.7 bits (91), Expect = 0.012
Identities = 27/128 (21%), Positives = 60/128 (46%), Gaps = 5/128 (3%)
Query: 25 QTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGP 82
+ +G + ++ G + ++ ++D D I+ +L + T P +L L +
Sbjct: 66 EKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECY-SVFTNQMPLGPMGFLKSALSFAEDE 124
Query: 83 KWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEV--GKTFDVHDYMSGTTVDIL 140
+W+ R +++P F K V I +Q + +V L+ E K+ ++ D+ T+D++
Sbjct: 125 EWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184
Query: 141 LETAMGIS 148
T G++
Sbjct: 185 TGTLFGVN 192
>AK223008-1|BAD96728.1| 502|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 5 variant protein.
Length = 502
Score = 123 bits (297), Expect = 1e-27
Identities = 76/236 (32%), Positives = 124/236 (52%), Gaps = 11/236 (4%)
Query: 269 EKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K RL FL LMI+S + + +SD E+ + +F G++TT++ SF L L H
Sbjct: 265 QKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATH 324
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ ++ E+ + + P T+ ++M+YL+ V+ E+LRL+P + R +DV I
Sbjct: 325 PDVQQKLQKEIDAVLPNK-APPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCMKDVEI 383
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRS 444
+ IP G+ VVI T+ LH PKY+ +PE F P+ F + + Y Y PF GPR+
Sbjct: 384 N--GVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF-SKKKDSIDPYIYTPFGTGPRN 440
Query: 445 CVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDI--ILKRAEGFQMKVEPR 498
C+G ++A +NF + E + L+ D +L+ + +KV+ R
Sbjct: 441 CIGMRFALMNMKLALIRVLQNF-SFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSR 495
Score = 39.5 bits (88), Expect = 0.027
Identities = 27/126 (21%), Positives = 57/126 (45%), Gaps = 5/126 (3%)
Query: 27 FGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGPKW 84
+G + + G ++ + D D I +L + T R P ++ + ++ +W
Sbjct: 68 YGKMWGTYEGQLPVLAITDPDVIRTVLVKECY-SVFTNRRSLGPVGFMKSAISLAEDEEW 126
Query: 85 RSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLK--SEVGKTFDVHDYMSGTTVDILLE 142
+ R +++PTF LK I Q + +V L+ +E GK + D ++D++
Sbjct: 127 KRIRPLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITG 186
Query: 143 TAMGIS 148
T+ G++
Sbjct: 187 TSFGVN 192
>X71480-1|CAA50586.1| 141|Homo sapiens cytochrome P450 protein.
Length = 141
Score = 119 bits (286), Expect = 3e-26
Identities = 61/145 (42%), Positives = 87/145 (60%), Gaps = 4/145 (2%)
Query: 301 TIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERV 360
T MFEGHDTTA+G S++L L H Q R +E++ + GD T+ +M Y
Sbjct: 1 TFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDG-ASITWNHLDQMPYTTMC 59
Query: 361 ILESLRLYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPD 420
I E+LRLYPPVP I+R+L+ VT +P G TV++ + LH PK + +PEVF+P
Sbjct: 60 IKEALRLYPPVPGISRELSTPVTF-PDGRSLPKGITVMLSIYGLHHNPKVWPNPEVFDPS 118
Query: 421 NFLPENTQNRHYYSYIPFSAGPRSC 445
F P + Q H ++++PFS G R+C
Sbjct: 119 RFAPGSAQ--HSHAFLPFSGGSRNC 141
>D12621-1|BAA02145.1| 389|Homo sapiens cytochrome P-450LTBV
protein.
Length = 389
Score = 106 bits (254), Expect = 2e-22
Identities = 69/218 (31%), Positives = 117/218 (53%), Gaps = 14/218 (6%)
Query: 5 IHVQEENLTQKLVNLALGYAQTFGNVIRVWLGS-KLIVFLVDADDIEIILNSHVHI---D 60
IH EE L L +L A TFG++ W+G IV + I+ +L + I D
Sbjct: 67 IHSSEEGL---LYTQSL--ACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPKD 121
Query: 61 KATEYRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEK--- 117
K Y F KPWLG+GLL+S+G KW HR+M+ P FH NILK ++ IFN++ N + K
Sbjct: 122 KVF-YSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQL 180
Query: 118 LKSEVGKTFDVHDYMSGTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKF 177
L SE D+ +++S T+D L + Q++ +Y A++++ ++ +RH +
Sbjct: 181 LASEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPS-EYIAAILELSALVTKRHQQI 239
Query: 178 WMRSEIVFKLTSFFKQQTKLLGIIHGLTNKVIKNKKET 215
+ + ++ LT ++ + ++H T+ VI+ ++ T
Sbjct: 240 LLYIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRT 277
Score = 72.1 bits (169), Expect = 4e-12
Identities = 37/98 (37%), Positives = 57/98 (58%), Gaps = 1/98 (1%)
Query: 269 EKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQ 328
+ K L F+D+++ S K+SD +I+ E DT MFEGHDTTA+G S+VL L H + Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351
Query: 329 ARVYDELYQIFGDSD-RPATFADTLEMKYLERVILESL 365
R E+ ++ D + + + D ++ +L I ESL
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESL 389
>BC022539-1|AAH22539.1| 500|Homo sapiens cytochrome P450, family
46, subfamily A, polypeptide 1 protein.
Length = 500
Score = 101 bits (242), Expect = 6e-21
Identities = 62/207 (29%), Positives = 99/207 (47%), Gaps = 6/207 (2%)
Query: 292 DHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADT 351
D + + T GH+T+A +F + L ++ AR+ E+ ++ G S R F D
Sbjct: 289 DEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIG-SKRYLDFEDL 347
Query: 352 LEMKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYY 411
++YL +V+ ESLRLYPP R L + I +P T ++ T+++ R Y+
Sbjct: 348 GRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVR--VPGNTPLLFSTYVMGRMDTYF 405
Query: 412 KDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISE 471
+DP FNPD F P + R ++Y PFS G RSC+G+++A +
Sbjct: 406 EDPLTFNPDRFGPGAPKPR--FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE-FRL 462
Query: 472 IPEKEFKLQGDIILKRAEGFQMKVEPR 498
+P + F LQ LK + + PR
Sbjct: 463 VPGQRFGLQEQATLKPLDPVLCTLRPR 489
Score = 48.8 bits (111), Expect = 4e-05
Identities = 38/140 (27%), Positives = 72/140 (51%), Gaps = 8/140 (5%)
Query: 16 LVNLALGYAQTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKPWLGEG 75
L ++ L +A+ +G V+RV + K V + + ++ L S + + YR + GE
Sbjct: 60 LQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGER 119
Query: 76 L----LIS--SGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEV-GKT-FD 127
L L+S + +W R++I F + L S + FN+ + +VE L+++ G+T
Sbjct: 120 LFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVS 179
Query: 128 VHDYMSGTTVDILLETAMGI 147
+ D ++ T +DIL + A G+
Sbjct: 180 MQDMLTYTAMDILAKAAFGM 199
>AF094480-1|AAD41244.1| 500|Homo sapiens cholesterol 24-hydroxylase
protein.
Length = 500
Score = 101 bits (242), Expect = 6e-21
Identities = 62/207 (29%), Positives = 99/207 (47%), Gaps = 6/207 (2%)
Query: 292 DHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADT 351
D + + T GH+T+A +F + L ++ AR+ E+ ++ G S R F D
Sbjct: 289 DEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIG-SKRYLDFEDL 347
Query: 352 LEMKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYY 411
++YL +V+ ESLRLYPP R L + I +P T ++ T+++ R Y+
Sbjct: 348 GRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVR--VPGNTPLLFSTYVMGRMDTYF 405
Query: 412 KDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISE 471
+DP FNPD F P + R ++Y PFS G RSC+G+++A +
Sbjct: 406 EDPLTFNPDRFGPGAPKPR--FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE-FRL 462
Query: 472 IPEKEFKLQGDIILKRAEGFQMKVEPR 498
+P + F LQ LK + + PR
Sbjct: 463 VPGQRFGLQEQATLKPLDPVLCTLRPR 489
Score = 48.8 bits (111), Expect = 4e-05
Identities = 38/140 (27%), Positives = 72/140 (51%), Gaps = 8/140 (5%)
Query: 16 LVNLALGYAQTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKPWLGEG 75
L ++ L +A+ +G V+RV + K V + + ++ L S + + YR + GE
Sbjct: 60 LQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGER 119
Query: 76 L----LIS--SGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEV-GKT-FD 127
L L+S + +W R++I F + L S + FN+ + +VE L+++ G+T
Sbjct: 120 LFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVS 179
Query: 128 VHDYMSGTTVDILLETAMGI 147
+ D ++ T +DIL + A G+
Sbjct: 180 MQDMLTYTAMDILAKAAFGM 199
>AL358613-3|CAH72804.1| 428|Homo sapiens cytochrome P450, family
26, subfamily A, polypeptide 1 protein.
Length = 428
Score = 95.9 bits (228), Expect = 3e-19
Identities = 56/180 (31%), Positives = 92/180 (51%), Gaps = 6/180 (3%)
Query: 276 LDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDEL 335
L L+IE S ++ +K+ ++F GH+TTA+ ++ ++ LG++ V +V +EL
Sbjct: 202 LQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREEL 261
Query: 336 YQ----IFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVI 391
+ D ++KY+ VI E+LRL PPVP R + T Y I
Sbjct: 262 KSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALK--TFELNGYQI 319
Query: 392 PAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYA 451
P G V+ H + + + E FNPD F+ + ++ +S+IPF G RSCVG+++A
Sbjct: 320 PKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFA 379
>AL358613-2|CAH72803.1| 497|Homo sapiens cytochrome P450, family
26, subfamily A, polypeptide 1 protein.
Length = 497
Score = 95.9 bits (228), Expect = 3e-19
Identities = 56/180 (31%), Positives = 92/180 (51%), Gaps = 6/180 (3%)
Query: 276 LDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDEL 335
L L+IE S ++ +K+ ++F GH+TTA+ ++ ++ LG++ V +V +EL
Sbjct: 271 LQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREEL 330
Query: 336 YQ----IFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVI 391
+ D ++KY+ VI E+LRL PPVP R + T Y I
Sbjct: 331 KSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALK--TFELNGYQI 388
Query: 392 PAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYA 451
P G V+ H + + + E FNPD F+ + ++ +S+IPF G RSCVG+++A
Sbjct: 389 PKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFA 448
>AF005418-1|AAB88881.1| 497|Homo sapiens retinoic acid hydroxylase
protein.
Length = 497
Score = 95.9 bits (228), Expect = 3e-19
Identities = 56/180 (31%), Positives = 92/180 (51%), Gaps = 6/180 (3%)
Query: 276 LDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDEL 335
L L+IE S ++ +K+ ++F GH+TTA+ ++ ++ LG++ V +V +EL
Sbjct: 271 LQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREEL 330
Query: 336 YQ----IFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVI 391
+ D ++KY+ VI E+LRL PPVP R + T Y I
Sbjct: 331 KSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALK--TFELNGYQI 388
Query: 392 PAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYA 451
P G V+ H + + + E FNPD F+ + ++ +S+IPF G RSCVG+++A
Sbjct: 389 PKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFA 448
>AY064484-1|AAL57719.1| 295|Homo sapiens truncated cytochrome P450
protein.
Length = 295
Score = 95.1 bits (226), Expect = 5e-19
Identities = 54/220 (24%), Positives = 103/220 (46%), Gaps = 6/220 (2%)
Query: 5 IHVQEENLTQKLVNLALGYAQTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATE 64
+ +QE K+V+ +A F +W G + + D + S
Sbjct: 59 LEIQETGSLDKVVS----WAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDV 114
Query: 65 YRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKL--KSEV 122
Y FF W+G GLL+ GPKW HRK++ P FH ++LK +V +F +++ +++K K+
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 123 GKTFDVHDYMSGTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSE 182
GK+FD+ + ++ L++ G Y +AV + ++ QR F ++
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHND 234
Query: 183 IVFKLTSFFKQQTKLLGIIHGLTNKVIKNKKETYLENKAK 222
++ LT ++ + + H T++VI+ +K + K +
Sbjct: 235 FIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVR 274
>U37143-1|AAC50370.2| 502|Homo sapiens cytochrome P450
monooxygenase CYP2J2 protein.
Length = 502
Score = 94.7 bits (225), Expect = 7e-19
Identities = 63/227 (27%), Positives = 113/227 (49%), Gaps = 8/227 (3%)
Query: 227 PTLEEFTHHSGEILANNAKTLSDTVFKGYRDDLDFNDENDVGEKKRL-AFLDLMIESSQN 285
P + +F + L +N K L +F + D D N + + A+L M + + N
Sbjct: 234 PWIMKFLPGPHQTLFSNWKKLK--LFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGN 291
Query: 286 GTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRP 345
T+ + + + F G +TT+ + L + ++ ++Q +V E+ ++ G +P
Sbjct: 292 PTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQP 351
Query: 346 ATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIPAGTTVVIGTFML 404
+T A M Y VI E R+ +P+ + R++ D T++ Y +P GT ++ L
Sbjct: 352 STAARE-SMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLA--GYHLPKGTMILTNLTAL 408
Query: 405 HRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYA 451
HR P + P+ FNPD+FL EN Q + +++PFS G R+C+G + A
Sbjct: 409 HRDPTEWATPDTFNPDHFL-ENGQFKKREAFMPFSIGKRACLGEQLA 454
Score = 37.9 bits (84), Expect = 0.083
Identities = 31/138 (22%), Positives = 59/138 (42%), Gaps = 10/138 (7%)
Query: 23 YAQTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP-----WLGEGLL 77
+ + +GN+ + LG V + + +I + +H+D+ R P + GL+
Sbjct: 71 FVKKYGNLFSLELGDISAVLITG---LPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLI 127
Query: 78 ISSGPKWRSHRKMIAPTFHINIL--KSFVGIFNQNSNNVVEKLKSEVGKTFDVHDYMSGT 135
+SSG W+ R+ L KS + + ++ E +K E G+ FD H ++
Sbjct: 128 MSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNA 187
Query: 136 TVDILLETAMGISRKTQD 153
+I+ G + QD
Sbjct: 188 VSNIICSITFGERFEYQD 205
>BC032594-1|AAH32594.1| 502|Homo sapiens cytochrome P450, family 2,
subfamily J, polypeptide 2 protein.
Length = 502
Score = 94.7 bits (225), Expect = 7e-19
Identities = 63/227 (27%), Positives = 113/227 (49%), Gaps = 8/227 (3%)
Query: 227 PTLEEFTHHSGEILANNAKTLSDTVFKGYRDDLDFNDENDVGEKKRL-AFLDLMIESSQN 285
P + +F + L +N K L +F + D D N + + A+L M + + N
Sbjct: 234 PWIMKFLPGPHQTLFSNWKKLK--LFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGN 291
Query: 286 GTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRP 345
T+ + + + F G +TT+ + L + ++ ++Q +V E+ ++ G +P
Sbjct: 292 PTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQP 351
Query: 346 ATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIPAGTTVVIGTFML 404
+T A M Y VI E R+ +P+ + R++ D T++ Y +P GT ++ L
Sbjct: 352 STAARE-SMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLA--GYHLPKGTMILTNLTAL 408
Query: 405 HRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYA 451
HR P + P+ FNPD+FL EN Q + +++PFS G R+C+G + A
Sbjct: 409 HRDPTEWATPDTFNPDHFL-ENGQFKKREAFMPFSIGKRACLGEQLA 454
Score = 37.9 bits (84), Expect = 0.083
Identities = 31/138 (22%), Positives = 59/138 (42%), Gaps = 10/138 (7%)
Query: 23 YAQTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP-----WLGEGLL 77
+ + +GN+ + LG V + + +I + +H+D+ R P + GL+
Sbjct: 71 FVKKYGNLFSLELGDISAVLITG---LPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLI 127
Query: 78 ISSGPKWRSHRKMIAPTFHINIL--KSFVGIFNQNSNNVVEKLKSEVGKTFDVHDYMSGT 135
+SSG W+ R+ L KS + + ++ E +K E G+ FD H ++
Sbjct: 128 MSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNA 187
Query: 136 TVDILLETAMGISRKTQD 153
+I+ G + QD
Sbjct: 188 VSNIICSITFGERFEYQD 205
>AY426985-1|AAQ93356.1| 502|Homo sapiens cytochrome P450, family 2,
subfamily J, polypeptide 2 protein.
Length = 502
Score = 94.7 bits (225), Expect = 7e-19
Identities = 63/227 (27%), Positives = 113/227 (49%), Gaps = 8/227 (3%)
Query: 227 PTLEEFTHHSGEILANNAKTLSDTVFKGYRDDLDFNDENDVGEKKRL-AFLDLMIESSQN 285
P + +F + L +N K L +F + D D N + + A+L M + + N
Sbjct: 234 PWIMKFLPGPHQTLFSNWKKLK--LFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGN 291
Query: 286 GTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRP 345
T+ + + + F G +TT+ + L + ++ ++Q +V E+ ++ G +P
Sbjct: 292 PTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQP 351
Query: 346 ATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIPAGTTVVIGTFML 404
+T A M Y VI E R+ +P+ + R++ D T++ Y +P GT ++ L
Sbjct: 352 STAARE-SMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLA--GYHLPKGTMILTNLTAL 408
Query: 405 HRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYA 451
HR P + P+ FNPD+FL EN Q + +++PFS G R+C+G + A
Sbjct: 409 HRDPTEWATPDTFNPDHFL-ENGQFKKREAFMPFSIGKRACLGEQLA 454
Score = 37.9 bits (84), Expect = 0.083
Identities = 31/138 (22%), Positives = 59/138 (42%), Gaps = 10/138 (7%)
Query: 23 YAQTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP-----WLGEGLL 77
+ + +GN+ + LG V + + +I + +H+D+ R P + GL+
Sbjct: 71 FVKKYGNLFSLELGDISAVLITG---LPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLI 127
Query: 78 ISSGPKWRSHRKMIAPTFHINIL--KSFVGIFNQNSNNVVEKLKSEVGKTFDVHDYMSGT 135
+SSG W+ R+ L KS + + ++ E +K E G+ FD H ++
Sbjct: 128 MSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNA 187
Query: 136 TVDILLETAMGISRKTQD 153
+I+ G + QD
Sbjct: 188 VSNIICSITFGERFEYQD 205
>AF272142-1|AAM44456.1| 502|Homo sapiens cytochrome P450 protein.
Length = 502
Score = 94.7 bits (225), Expect = 7e-19
Identities = 63/227 (27%), Positives = 113/227 (49%), Gaps = 8/227 (3%)
Query: 227 PTLEEFTHHSGEILANNAKTLSDTVFKGYRDDLDFNDENDVGEKKRL-AFLDLMIESSQN 285
P + +F + L +N K L +F + D D N + + A+L M + + N
Sbjct: 234 PWIMKFLPGPHQTLFSNWKKLK--LFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGN 291
Query: 286 GTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRP 345
T+ + + + F G +TT+ + L + ++ ++Q +V E+ ++ G +P
Sbjct: 292 PTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQP 351
Query: 346 ATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIPAGTTVVIGTFML 404
+T A M Y VI E R+ +P+ + R++ D T++ Y +P GT ++ L
Sbjct: 352 STAARE-SMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLA--GYHLPKGTMILTNLTAL 408
Query: 405 HRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYA 451
HR P + P+ FNPD+FL EN Q + +++PFS G R+C+G + A
Sbjct: 409 HRDPTEWATPDTFNPDHFL-ENGQFKKREAFMPFSIGKRACLGEQLA 454
Score = 37.9 bits (84), Expect = 0.083
Identities = 31/138 (22%), Positives = 59/138 (42%), Gaps = 10/138 (7%)
Query: 23 YAQTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP-----WLGEGLL 77
+ + +GN+ + LG V + + +I + +H+D+ R P + GL+
Sbjct: 71 FVKKYGNLFSLELGDISAVLITG---LPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLI 127
Query: 78 ISSGPKWRSHRKMIAPTFHINIL--KSFVGIFNQNSNNVVEKLKSEVGKTFDVHDYMSGT 135
+SSG W+ R+ L KS + + ++ E +K E G+ FD H ++
Sbjct: 128 MSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNA 187
Query: 136 TVDILLETAMGISRKTQD 153
+I+ G + QD
Sbjct: 188 VSNIICSITFGERFEYQD 205
>M80647-1|AAA60618.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 94.3 bits (224), Expect = 9e-19
Identities = 56/188 (29%), Positives = 86/188 (45%), Gaps = 5/188 (2%)
Query: 294 EIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLE 353
EI + + G++ SF LL + D Q ++ E+ +F + F E
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFKEKHMAPEFCSLEE 389
Query: 354 -MKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYK 412
+ YL+ VI E+LR+YPP R+ +D + + IPAG + + LH P+++
Sbjct: 390 GLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQR--IPAGAVLEMAVGALHHDPEHWP 447
Query: 413 DPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEI 472
PE FNP+ F E Q ++Y+PF AGPRSC+G + FR
Sbjct: 448 SPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR-FQAC 506
Query: 473 PEKEFKLQ 480
PE + LQ
Sbjct: 507 PETQVPLQ 514
>BC132767-1|AAI32768.1| 544|Homo sapiens cytochrome P450, family 2,
subfamily U, polypeptide 1 protein.
Length = 544
Score = 94.3 bits (224), Expect = 9e-19
Identities = 57/202 (28%), Positives = 101/202 (50%), Gaps = 7/202 (3%)
Query: 251 VFKGYRDDLDFNDENDVGEKKRLAFLDLMIESSQNGTNKISDHE-IKEEVDTIMFEGHDT 309
+ K +++ LD + D + +L M E +N +N D E + + + G DT
Sbjct: 301 IIKDHQESLDRENPQDFIDM----YLLHMEEERKNNSNSSFDEEYLFYIIGDLFIAGTDT 356
Query: 310 TAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYP 369
T + L + ++ DVQ +V++E+ ++ G ++R + D +M Y E I+E RL
Sbjct: 357 TTNSLLWCLLYMSLNPDVQEKVHEEIERVIG-ANRAPSLTDKAQMPYTEATIMEVQRLTV 415
Query: 370 PVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQN 429
VP+ + + T+ + Y IP GT ++ + +HR P ++ PE F P+ FL + Q
Sbjct: 416 VVPLAIPHMTSENTV-LQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQL 474
Query: 430 RHYYSYIPFSAGPRSCVGRKYA 451
++IPF G R C+G + A
Sbjct: 475 IKKETFIPFGIGKRVCMGEQLA 496
>BC104909-1|AAI04910.1| 501|Homo sapiens cytochrome P450, family 2,
subfamily R, polypeptide 1 protein.
Length = 501
Score = 94.3 bits (224), Expect = 9e-19
Identities = 53/179 (29%), Positives = 92/179 (51%), Gaps = 4/179 (2%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
A+LD M + + ++ S + V ++ G +TT + + + ++ ++Q +V
Sbjct: 279 AYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQK 338
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ I G + +P+ + D +M Y E V+ E LR VP+ I + D + + Y IP
Sbjct: 339 EIDLIMGPNGKPS-WDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVV--RGYSIP 395
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYA 451
GTTV+ + +H KY++DPEVF+P+ FL + + +PFS G R C+G A
Sbjct: 396 KGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLA 454
>BC104907-1|AAI04908.1| 501|Homo sapiens cytochrome P450, family 2,
subfamily R, polypeptide 1 protein.
Length = 501
Score = 94.3 bits (224), Expect = 9e-19
Identities = 53/179 (29%), Positives = 92/179 (51%), Gaps = 4/179 (2%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
A+LD M + + ++ S + V ++ G +TT + + + ++ ++Q +V
Sbjct: 279 AYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQK 338
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ I G + +P+ + D +M Y E V+ E LR VP+ I + D + + Y IP
Sbjct: 339 EIDLIMGPNGKPS-WDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVV--RGYSIP 395
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYA 451
GTTV+ + +H KY++DPEVF+P+ FL + + +PFS G R C+G A
Sbjct: 396 KGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLA 454
>BC041157-1|AAH41157.1| 534|Homo sapiens thromboxane A synthase 1
(platelet, cytochrome P450, family 5, subfamily A)
protein.
Length = 534
Score = 94.3 bits (224), Expect = 9e-19
Identities = 56/188 (29%), Positives = 86/188 (45%), Gaps = 5/188 (2%)
Query: 294 EIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLE 353
EI + + G++ SF LL + D Q ++ E+ +F + F E
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFKEKHMAPEFCSLEE 389
Query: 354 -MKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYK 412
+ YL+ VI E+LR+YPP R+ +D + + IPAG + + LH P+++
Sbjct: 390 GLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQR--IPAGAVLEMAVGALHHDPEHWP 447
Query: 413 DPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEI 472
PE FNP+ F E Q ++Y+PF AGPRSC+G + FR
Sbjct: 448 SPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR-FQAC 506
Query: 473 PEKEFKLQ 480
PE + LQ
Sbjct: 507 PETQVPLQ 514
>BC014117-1|AAH14117.1| 466|Homo sapiens TBXAS1 protein protein.
Length = 466
Score = 94.3 bits (224), Expect = 9e-19
Identities = 56/188 (29%), Positives = 86/188 (45%), Gaps = 5/188 (2%)
Query: 294 EIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLE 353
EI + + G++ SF LL + D Q ++ E+ +F + F E
Sbjct: 263 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFKEKHMAPEFCSLEE 321
Query: 354 -MKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYK 412
+ YL+ VI E+LR+YPP R+ +D + + IPAG + + LH P+++
Sbjct: 322 GLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQR--IPAGAVLEMAVGALHHDPEHWP 379
Query: 413 DPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEI 472
PE FNP+ F E Q ++Y+PF AGPRSC+G + FR
Sbjct: 380 SPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR-FQAC 438
Query: 473 PEKEFKLQ 480
PE + LQ
Sbjct: 439 PETQVPLQ 446
>AY343323-1|AAQ21380.1| 544|Homo sapiens cytochrome P450 protein.
Length = 544
Score = 94.3 bits (224), Expect = 9e-19
Identities = 57/202 (28%), Positives = 101/202 (50%), Gaps = 7/202 (3%)
Query: 251 VFKGYRDDLDFNDENDVGEKKRLAFLDLMIESSQNGTNKISDHE-IKEEVDTIMFEGHDT 309
+ K +++ LD + D + +L M E +N +N D E + + + G DT
Sbjct: 301 IIKDHQESLDRENPQDFIDM----YLLHMEEERKNNSNSSFDEEYLFYIIGDLFIAGTDT 356
Query: 310 TAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYP 369
T + L + ++ DVQ +V++E+ ++ G ++R + D +M Y E I+E RL
Sbjct: 357 TTNSLLWCLLYMSLNPDVQEKVHEEIERVIG-ANRAPSLTDKAQMPYTEATIMEVQRLTV 415
Query: 370 PVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQN 429
VP+ + + T+ + Y IP GT ++ + +HR P ++ PE F P+ FL + Q
Sbjct: 416 VVPLAIPHMTSENTV-LQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQL 474
Query: 430 RHYYSYIPFSAGPRSCVGRKYA 451
++IPF G R C+G + A
Sbjct: 475 IKKETFIPFGIGKRVCMGEQLA 496
>AY323817-1|AAQ23114.1| 501|Homo sapiens cytochrome P450 2R1
protein.
Length = 501
Score = 94.3 bits (224), Expect = 9e-19
Identities = 53/179 (29%), Positives = 92/179 (51%), Gaps = 4/179 (2%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
A+LD M + + ++ S + V ++ G +TT + + + ++ ++Q +V
Sbjct: 279 AYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQK 338
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ I G + +P+ + D +M Y E V+ E LR VP+ I + D + + Y IP
Sbjct: 339 EIDLIMGPNGKPS-WDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVV--RGYSIP 395
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYA 451
GTTV+ + +H KY++DPEVF+P+ FL + + +PFS G R C+G A
Sbjct: 396 KGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLA 454
>AK223466-1|BAD97186.1| 534|Homo sapiens thromboxane A synthase 1
(platelet, cytochrome P450, family 5, subfamily A) iso
protein.
Length = 534
Score = 94.3 bits (224), Expect = 9e-19
Identities = 56/188 (29%), Positives = 86/188 (45%), Gaps = 5/188 (2%)
Query: 294 EIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLE 353
EI + + G++ SF LL + D Q ++ E+ +F + F E
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFKEKHMAPEFCSLEE 389
Query: 354 -MKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYK 412
+ YL+ VI E+LR+YPP R+ +D + + IPAG + + LH P+++
Sbjct: 390 GLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQR--IPAGAVLEMAVGALHHDPEHWP 447
Query: 413 DPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEI 472
PE FNP+ F E Q ++Y+PF AGPRSC+G + FR
Sbjct: 448 SPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR-FQAC 506
Query: 473 PEKEFKLQ 480
PE + LQ
Sbjct: 507 PETQVPLQ 514
>AF233625-1|AAF99279.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 94.3 bits (224), Expect = 9e-19
Identities = 56/188 (29%), Positives = 86/188 (45%), Gaps = 5/188 (2%)
Query: 294 EIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLE 353
EI + + G++ SF LL + D Q ++ E+ +F + F E
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFKEKHMAPEFCSLEE 389
Query: 354 -MKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYK 412
+ YL+ VI E+LR+YPP R+ +D + + IPAG + + LH P+++
Sbjct: 390 GLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQR--IPAGAVLEMAVGALHHDPEHWP 447
Query: 413 DPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEI 472
PE FNP+ F E Q ++Y+PF AGPRSC+G + FR
Sbjct: 448 SPETFNPERFTAEARQQHQPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR-FQAC 506
Query: 473 PEKEFKLQ 480
PE + LQ
Sbjct: 507 PETQVPLQ 514
>AF233620-1|AAF99274.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 94.3 bits (224), Expect = 9e-19
Identities = 56/188 (29%), Positives = 86/188 (45%), Gaps = 5/188 (2%)
Query: 294 EIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLE 353
EI + + G++ SF LL + D Q ++ E+ +F + F E
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFKEKHMAPEFCSLEE 389
Query: 354 -MKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYK 412
+ YL+ VI E+LR+YPP R+ +D + + IPAG + + LH P+++
Sbjct: 390 GLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQR--IPAGAVLEMAVGALHHDPEHWP 447
Query: 413 DPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEI 472
PE FNP+ F E Q ++Y+PF AGPRSC+G + FR
Sbjct: 448 SPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR-FQAC 506
Query: 473 PEKEFKLQ 480
PE + LQ
Sbjct: 507 PETQVPLQ 514
>AF233619-1|AAF99273.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 94.3 bits (224), Expect = 9e-19
Identities = 56/188 (29%), Positives = 86/188 (45%), Gaps = 5/188 (2%)
Query: 294 EIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLE 353
EI + + G++ SF LL + D Q ++ E+ +F + F E
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFKEKHMAPEFCSLEE 389
Query: 354 -MKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYK 412
+ YL+ VI E+LR+YPP R+ +D + + IPAG + + LH P+++
Sbjct: 390 GLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQR--IPAGAVLEMAVGALHHDPEHWP 447
Query: 413 DPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEI 472
PE FNP+ F E Q ++Y+PF AGPRSC+G + FR
Sbjct: 448 SPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR-FQAC 506
Query: 473 PEKEFKLQ 480
PE + LQ
Sbjct: 507 PETQVPLQ 514
>AF233618-1|AAF99272.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 94.3 bits (224), Expect = 9e-19
Identities = 56/188 (29%), Positives = 86/188 (45%), Gaps = 5/188 (2%)
Query: 294 EIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLE 353
EI + + G++ SF LL + D Q ++ E+ +F + F E
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFKEKHMAPEFCSLEE 389
Query: 354 -MKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYK 412
+ YL+ VI E+LR+YPP R+ +D + + IPAG + + LH P+++
Sbjct: 390 GLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQR--IPAGAVLEMAVGALHHDPEHWP 447
Query: 413 DPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEI 472
PE FNP+ F E Q ++Y+PF AGPRSC+G + FR
Sbjct: 448 SPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR-FQAC 506
Query: 473 PEKEFKLQ 480
PE + LQ
Sbjct: 507 PETQVPLQ 514
>AF233617-1|AAF99271.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 94.3 bits (224), Expect = 9e-19
Identities = 56/188 (29%), Positives = 86/188 (45%), Gaps = 5/188 (2%)
Query: 294 EIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLE 353
EI + + G++ SF LL + D Q ++ E+ +F + F E
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFKEKHMAPEFCSLEE 389
Query: 354 -MKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYK 412
+ YL+ VI E+LR+YPP R+ +D + + IPAG + + LH P+++
Sbjct: 390 GLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQR--IPAGAVLEMAVGALHHDPEHWP 447
Query: 413 DPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEI 472
PE FNP+ F E Q ++Y+PF AGPRSC+G + FR
Sbjct: 448 SPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR-FQAC 506
Query: 473 PEKEFKLQ 480
PE + LQ
Sbjct: 507 PETQVPLQ 514
>AF233616-1|AAF99270.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 94.3 bits (224), Expect = 9e-19
Identities = 56/188 (29%), Positives = 86/188 (45%), Gaps = 5/188 (2%)
Query: 294 EIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLE 353
EI + + G++ SF LL + D Q ++ E+ +F + F E
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFKEKHMAPEFCSLEE 389
Query: 354 -MKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYK 412
+ YL+ VI E+LR+YPP R+ +D + + IPAG + + LH P+++
Sbjct: 390 GLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQR--IPAGAVLEMAVGALHHDPEHWP 447
Query: 413 DPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEI 472
PE FNP+ F E Q ++Y+PF AGPRSC+G + FR
Sbjct: 448 SPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR-FQAC 506
Query: 473 PEKEFKLQ 480
PE + LQ
Sbjct: 507 PETQVPLQ 514
>AF233615-1|AAF99269.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 94.3 bits (224), Expect = 9e-19
Identities = 56/188 (29%), Positives = 86/188 (45%), Gaps = 5/188 (2%)
Query: 294 EIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLE 353
EI + + G++ SF LL + D Q ++ E+ +F + F E
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFKEKHMAPEFCSLEE 389
Query: 354 -MKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYK 412
+ YL+ VI E+LR+YPP R+ +D + + IPAG + + LH P+++
Sbjct: 390 GLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQR--IPAGAVLEMAVGALHHDPEHWP 447
Query: 413 DPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEI 472
PE FNP+ F E Q ++Y+PF AGPRSC+G + FR
Sbjct: 448 SPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR-FQAC 506
Query: 473 PEKEFKLQ 480
PE + LQ
Sbjct: 507 PETQVPLQ 514
>AB080265-1|BAB85489.1| 502|Homo sapiens cytochrome P450 2J2
protein.
Length = 502
Score = 94.3 bits (224), Expect = 9e-19
Identities = 63/227 (27%), Positives = 113/227 (49%), Gaps = 8/227 (3%)
Query: 227 PTLEEFTHHSGEILANNAKTLSDTVFKGYRDDLDFNDENDVGEKKRL-AFLDLMIESSQN 285
P + +F + L +N K L +F + D D N + + A+L M + + N
Sbjct: 234 PWIMKFLPGPHQTLFSNWKKLK--LFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGN 291
Query: 286 GTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRP 345
T+ + + + F G +TT+ + L + ++ ++Q +V E+ ++ G +P
Sbjct: 292 PTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQVEIDRVIGQGQQP 351
Query: 346 ATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIPAGTTVVIGTFML 404
+T A M Y VI E R+ +P+ + R++ D T++ Y +P GT ++ L
Sbjct: 352 STAARE-SMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLA--GYHLPKGTMILTNLTAL 408
Query: 405 HRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYA 451
HR P + P+ FNPD+FL EN Q + +++PFS G R+C+G + A
Sbjct: 409 HRDPTEWATPDTFNPDHFL-ENGQFKKREAFMPFSIGKRACLGEQLA 454
Score = 37.9 bits (84), Expect = 0.083
Identities = 31/138 (22%), Positives = 59/138 (42%), Gaps = 10/138 (7%)
Query: 23 YAQTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP-----WLGEGLL 77
+ + +GN+ + LG V + + +I + +H+D+ R P + GL+
Sbjct: 71 FVKKYGNLFSLELGDISAVLITG---LPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLI 127
Query: 78 ISSGPKWRSHRKMIAPTFHINIL--KSFVGIFNQNSNNVVEKLKSEVGKTFDVHDYMSGT 135
+SSG W+ R+ L KS + + ++ E +K E G+ FD H ++
Sbjct: 128 MSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNA 187
Query: 136 TVDILLETAMGISRKTQD 153
+I+ G + QD
Sbjct: 188 VSNIICSITFGERFEYQD 205
>AF233622-1|AAF99276.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 93.9 bits (223), Expect = 1e-18
Identities = 56/188 (29%), Positives = 85/188 (45%), Gaps = 5/188 (2%)
Query: 294 EIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLE 353
EI + + G++ SF LL + D Q ++ E+ +F + F E
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFKEKHMAPEFCSLEE 389
Query: 354 -MKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYK 412
+ YL+ VI E+LR+YPP R+ D + + IPAG + + LH P+++
Sbjct: 390 GLPYLDMVIAETLRMYPPAFRFTREAAEDCEVLGQR--IPAGAVLEMAVGALHHDPEHWP 447
Query: 413 DPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEI 472
PE FNP+ F E Q ++Y+PF AGPRSC+G + FR
Sbjct: 448 SPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR-FQAC 506
Query: 473 PEKEFKLQ 480
PE + LQ
Sbjct: 507 PETQVPLQ 514
>D34625-1|BAA07011.1| 533|Homo sapiens thromboxane synthase
protein.
Length = 533
Score = 93.1 bits (221), Expect = 2e-18
Identities = 56/188 (29%), Positives = 85/188 (45%), Gaps = 5/188 (2%)
Query: 294 EIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLE 353
EI + + G++ SF LL + D Q ++ E+ +F + F E
Sbjct: 330 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFKEKHMAPEFCSLEE 388
Query: 354 -MKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYK 412
+ YL+ VI E+LR+YPP R+ +D + + IPAG + + LH P+++
Sbjct: 389 GLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQR--IPAGAVLEMAVGALHHDPEHWP 446
Query: 413 DPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEI 472
PE FNP+ F E Q ++Y+PF AGPRSC+G FR
Sbjct: 447 SPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVHLGLLEVKLTLLHVLHKFR-FQAC 505
Query: 473 PEKEFKLQ 480
PE + LQ
Sbjct: 506 PETQVPLQ 513
>AF233624-1|AAF99278.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 93.1 bits (221), Expect = 2e-18
Identities = 56/188 (29%), Positives = 86/188 (45%), Gaps = 5/188 (2%)
Query: 294 EIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLE 353
EI + + G++ SF LL + D Q ++ E+ +F + F E
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFKEKHMAPEFCSLEE 389
Query: 354 -MKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYK 412
+ YL+ VI E+LR+YPP R+ +D + + IPAG + + LH P+++
Sbjct: 390 GLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQR--IPAGAVLEMAVGALHHDPEHWP 447
Query: 413 DPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEI 472
PE FNP+ F E Q ++Y+PF AGPRSC+G + FR
Sbjct: 448 SPENFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR-FQAC 506
Query: 473 PEKEFKLQ 480
PE + LQ
Sbjct: 507 PETQVPLQ 514
>AF233621-1|AAF99275.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 93.1 bits (221), Expect = 2e-18
Identities = 55/188 (29%), Positives = 86/188 (45%), Gaps = 5/188 (2%)
Query: 294 EIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLE 353
EI + + G++ SF +L + D Q ++ E+ +F + F E
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYVLATNPDCQEKLLREV-DVFKEKHMAPEFCSLEE 389
Query: 354 -MKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYK 412
+ YL+ VI E+LR+YPP R+ +D + + IPAG + + LH P+++
Sbjct: 390 GLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQR--IPAGAVLEMAVGALHHDPEHWP 447
Query: 413 DPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEI 472
PE FNP+ F E Q ++Y+PF AGPRSC+G + FR
Sbjct: 448 SPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR-FQAC 506
Query: 473 PEKEFKLQ 480
PE + LQ
Sbjct: 507 PETQVPLQ 514
>AF280110-1|AAG33011.1| 420|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 420
Score = 92.7 bits (220), Expect = 3e-18
Identities = 50/156 (32%), Positives = 86/156 (55%), Gaps = 7/156 (4%)
Query: 269 EKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIH 324
+K R+ F MI+S + K +SD E+ + I+F +DTT+ F++ L H
Sbjct: 265 QKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATH 324
Query: 325 QDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTI 384
DVQ ++ +E+ + + P T+ ++M+YL+ V+ E+LRL+P V + R +D+ I
Sbjct: 325 PDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI 383
Query: 385 STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPD 420
+ IP G V++ + LH PKY+ +PE F P+
Sbjct: 384 N--GVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPE 417
Score = 40.7 bits (91), Expect = 0.012
Identities = 27/128 (21%), Positives = 60/128 (46%), Gaps = 5/128 (3%)
Query: 25 QTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKP--WLGEGLLISSGP 82
+ +G + ++ G + ++ ++D D I+ +L + T P +L L +
Sbjct: 66 EKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECY-SVFTNQMPLGPMGFLKSALSFAEDE 124
Query: 83 KWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEV--GKTFDVHDYMSGTTVDIL 140
+W+ R +++P F K V I +Q + +V L+ E K+ ++ D+ T+D++
Sbjct: 125 EWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184
Query: 141 LETAMGIS 148
T G++
Sbjct: 185 TGTLFGVN 192
>AF233623-1|AAF99277.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 92.7 bits (220), Expect = 3e-18
Identities = 55/188 (29%), Positives = 86/188 (45%), Gaps = 5/188 (2%)
Query: 294 EIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLE 353
EI + + G++ SF LL + D Q ++ E+ +F + F E
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFKEKHMAPEFCSLEE 389
Query: 354 -MKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYK 412
+ YL+ VI E+LR+YPP R+ +D + + IPAG + + LH P+++
Sbjct: 390 GLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQR--IPAGAVLEMAVGALHHDPEHWP 447
Query: 413 DPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEI 472
P+ FNP+ F E Q ++Y+PF AGPRSC+G + FR
Sbjct: 448 SPKTFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR-FQAC 506
Query: 473 PEKEFKLQ 480
PE + LQ
Sbjct: 507 PETQVPLQ 514
>M63871-1|AAA59984.1| 508|Homo sapiens CYP17 protein.
Length = 508
Score = 92.3 bits (219), Expect = 4e-18
Identities = 75/253 (29%), Positives = 122/253 (48%), Gaps = 18/253 (7%)
Query: 208 VIKNKKETYLENKAKGIIP---PTLEEFTHHSGEILANNAKTLSDT---VFKGYRDDLDF 261
VI+N E ++N +K + P L+ F + + E L ++ K +D + + Y++ F
Sbjct: 197 VIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEK--F 254
Query: 262 NDENDVGEKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFV 317
++ L + ++ G ++ +SD+ I + I G +TT + +
Sbjct: 255 RSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWT 314
Query: 318 LCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IAR 376
L L + V+ ++Y+E+ Q G S P T +D + LE I E LRL P P+ I
Sbjct: 315 LAFLLHNPQVKKKLYEEIDQNVGFSRTP-TISDRNRLLLLEATIREVLRLRPVAPMLIPH 373
Query: 377 KLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFL-PENTQ-NRHYYS 434
K N D +I + + GT V+I + LH K + P+ F P+ FL P TQ S
Sbjct: 374 KANVDSSIG--EFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVS 431
Query: 435 YIPFSAGPRSCVG 447
Y+PF AGPRSC+G
Sbjct: 432 YLPFGAGPRSCIG 444
>M31153-1|AAA52140.1| 508|Homo sapiens CYP17 protein.
Length = 508
Score = 92.3 bits (219), Expect = 4e-18
Identities = 75/253 (29%), Positives = 122/253 (48%), Gaps = 18/253 (7%)
Query: 208 VIKNKKETYLENKAKGIIP---PTLEEFTHHSGEILANNAKTLSDT---VFKGYRDDLDF 261
VI+N E ++N +K + P L+ F + + E L ++ K +D + + Y++ F
Sbjct: 197 VIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEK--F 254
Query: 262 NDENDVGEKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFV 317
++ L + ++ G ++ +SD+ I + I G +TT + +
Sbjct: 255 RSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWT 314
Query: 318 LCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IAR 376
L L + V+ ++Y+E+ Q G S P T +D + LE I E LRL P P+ I
Sbjct: 315 LAFLLHNPQVKKKLYEEIDQNVGFSRTP-TISDRNRLLLLEATIREVLRLRPVAPMLIPH 373
Query: 377 KLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFL-PENTQ-NRHYYS 434
K N D +I + + GT V+I + LH K + P+ F P+ FL P TQ S
Sbjct: 374 KANVDSSIG--EFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVS 431
Query: 435 YIPFSAGPRSCVG 447
Y+PF AGPRSC+G
Sbjct: 432 YLPFGAGPRSCIG 444
>M19489-1|AAA36405.1| 508|Homo sapiens CYP17 protein.
Length = 508
Score = 92.3 bits (219), Expect = 4e-18
Identities = 75/253 (29%), Positives = 122/253 (48%), Gaps = 18/253 (7%)
Query: 208 VIKNKKETYLENKAKGIIP---PTLEEFTHHSGEILANNAKTLSDT---VFKGYRDDLDF 261
VI+N E ++N +K + P L+ F + + E L ++ K +D + + Y++ F
Sbjct: 197 VIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEK--F 254
Query: 262 NDENDVGEKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFV 317
++ L + ++ G ++ +SD+ I + I G +TT + +
Sbjct: 255 RSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWT 314
Query: 318 LCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IAR 376
L L + V+ ++Y+E+ Q G S P T +D + LE I E LRL P P+ I
Sbjct: 315 LAFLLHNPQVKKKLYEEIDQNVGFSRTP-TISDRNRLLLLEATIREVLRLRPVAPMLIPH 373
Query: 377 KLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFL-PENTQ-NRHYYS 434
K N D +I + + GT V+I + LH K + P+ F P+ FL P TQ S
Sbjct: 374 KANVDSSIG--EFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVS 431
Query: 435 YIPFSAGPRSCVG 447
Y+PF AGPRSC+G
Sbjct: 432 YLPFGAGPRSCIG 444
>M14564-1|AAA52151.1| 508|Homo sapiens CYP17 protein.
Length = 508
Score = 92.3 bits (219), Expect = 4e-18
Identities = 75/253 (29%), Positives = 122/253 (48%), Gaps = 18/253 (7%)
Query: 208 VIKNKKETYLENKAKGIIP---PTLEEFTHHSGEILANNAKTLSDT---VFKGYRDDLDF 261
VI+N E ++N +K + P L+ F + + E L ++ K +D + + Y++ F
Sbjct: 197 VIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEK--F 254
Query: 262 NDENDVGEKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFV 317
++ L + ++ G ++ +SD+ I + I G +TT + +
Sbjct: 255 RSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWT 314
Query: 318 LCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IAR 376
L L + V+ ++Y+E+ Q G S P T +D + LE I E LRL P P+ I
Sbjct: 315 LAFLLHNPQVKKKLYEEIDQNVGFSRTP-TISDRNRLLLLEATIREVLRLRPVAPMLIPH 373
Query: 377 KLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFL-PENTQ-NRHYYS 434
K N D +I + + GT V+I + LH K + P+ F P+ FL P TQ S
Sbjct: 374 KANVDSSIG--EFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVS 431
Query: 435 YIPFSAGPRSCVG 447
Y+PF AGPRSC+G
Sbjct: 432 YLPFGAGPRSCIG 444
>DQ530598-1|ABF50972.1| 508|Homo sapiens cytochrome P450, family
17, subfamily A, polypeptide 1 protein.
Length = 508
Score = 92.3 bits (219), Expect = 4e-18
Identities = 75/253 (29%), Positives = 122/253 (48%), Gaps = 18/253 (7%)
Query: 208 VIKNKKETYLENKAKGIIP---PTLEEFTHHSGEILANNAKTLSDT---VFKGYRDDLDF 261
VI+N E ++N +K + P L+ F + + E L ++ K +D + + Y++ F
Sbjct: 197 VIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEK--F 254
Query: 262 NDENDVGEKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFV 317
++ L + ++ G ++ +SD+ I + I G +TT + +
Sbjct: 255 RSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWT 314
Query: 318 LCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IAR 376
L L + V+ ++Y+E+ Q G S P T +D + LE I E LRL P P+ I
Sbjct: 315 LAFLLHNPQVKKKLYEEIDQNVGFSRTP-TISDRNRLLLLEATIREVLRLRPVAPMLIPH 373
Query: 377 KLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFL-PENTQ-NRHYYS 434
K N D +I + + GT V+I + LH K + P+ F P+ FL P TQ S
Sbjct: 374 KANVDSSIG--EFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVS 431
Query: 435 YIPFSAGPRSCVG 447
Y+PF AGPRSC+G
Sbjct: 432 YLPFGAGPRSCIG 444
>BT020000-1|AAV38803.1| 508|Homo sapiens cytochrome P450, family
17, subfamily A, polypeptide 1 protein.
Length = 508
Score = 92.3 bits (219), Expect = 4e-18
Identities = 75/253 (29%), Positives = 122/253 (48%), Gaps = 18/253 (7%)
Query: 208 VIKNKKETYLENKAKGIIP---PTLEEFTHHSGEILANNAKTLSDT---VFKGYRDDLDF 261
VI+N E ++N +K + P L+ F + + E L ++ K +D + + Y++ F
Sbjct: 197 VIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEK--F 254
Query: 262 NDENDVGEKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFV 317
++ L + ++ G ++ +SD+ I + I G +TT + +
Sbjct: 255 RSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWT 314
Query: 318 LCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IAR 376
L L + V+ ++Y+E+ Q G S P T +D + LE I E LRL P P+ I
Sbjct: 315 LAFLLHNPQVKKKLYEEIDQNVGFSRTP-TISDRNRLLLLEATIREVLRLRPVAPMLIPH 373
Query: 377 KLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFL-PENTQ-NRHYYS 434
K N D +I + + GT V+I + LH K + P+ F P+ FL P TQ S
Sbjct: 374 KANVDSSIG--EFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVS 431
Query: 435 YIPFSAGPRSCVG 447
Y+PF AGPRSC+G
Sbjct: 432 YLPFGAGPRSCIG 444
>BC067431-1|AAH67431.1| 491|Homo sapiens cytochrome P450, family 2,
subfamily B, polypeptide 6 protein.
Length = 491
Score = 92.3 bits (219), Expect = 4e-18
Identities = 99/466 (21%), Positives = 183/466 (39%), Gaps = 48/466 (10%)
Query: 16 LVNLALGYAQTFGNVIRVWLGSKLIVFLVDADDI-EIILNSHVHIDKATEYRFFKPWL-G 73
L+ L + + +G+V V LG + +V L + I E +++ + P+ G
Sbjct: 51 LLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRG 110
Query: 74 EGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGKTFDVHDYMS 133
G++ ++G +W+ R+ F + ++ F +V E+++ E
Sbjct: 111 YGVIFANGNRWKVLRR-----FSVTTMRDF----GMGKRSVEERIQEEA----------- 150
Query: 134 GTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSEIVFKLTSFFKQ 193
L+E D + ++ +C I+ + + + + + K+ + F Q
Sbjct: 151 ----QCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHY--QDQEFLKMLNLFYQ 204
Query: 194 QTKLLGIIHGLTNKVIKNKKETYLENKAKGIIPPTLEEFTHHSGEILANNAKTLSDTVFK 253
L+ + G ++ TY + + L+E + G + + +TL + K
Sbjct: 205 TFSLISSVFGQLFELFSGFL-TYFPGAHRQVYK-NLQEINAYIGHSVEKHRETLDPSAPK 262
Query: 254 GYRDDLDFNDENDVGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAG 313
D +L M E N ++ S + ++ F G +TT+
Sbjct: 263 DLID----------------TYLLHMEEEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTT 306
Query: 314 SSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV 373
+ L+ + V RVY E+ Q+ G RP D +M Y E VI E R +P+
Sbjct: 307 LRYGFLLMLKYPHVAERVYREIEQVIGPH-RPPELHDRAKMPYTEAVIYEIQRFSDLLPM 365
Query: 374 IARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYY 433
+ T S + Y+IP T V + P Y++ P+ FNPD+FL N +
Sbjct: 366 GVPHIVTQHT-SFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTE 424
Query: 434 SYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKL 479
++IPFS G R C+G A +NF S + ++ L
Sbjct: 425 AFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDL 470
>BC063388-1|AAH63388.1| 508|Homo sapiens cytochrome P450, family
17, subfamily A, polypeptide 1 protein.
Length = 508
Score = 92.3 bits (219), Expect = 4e-18
Identities = 75/253 (29%), Positives = 122/253 (48%), Gaps = 18/253 (7%)
Query: 208 VIKNKKETYLENKAKGIIP---PTLEEFTHHSGEILANNAKTLSDT---VFKGYRDDLDF 261
VI+N E ++N +K + P L+ F + + E L ++ K +D + + Y++ F
Sbjct: 197 VIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEK--F 254
Query: 262 NDENDVGEKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFV 317
++ L + ++ G ++ +SD+ I + I G +TT + +
Sbjct: 255 RSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWT 314
Query: 318 LCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IAR 376
L L + V+ ++Y+E+ Q G S P T +D + LE I E LRL P P+ I
Sbjct: 315 LAFLLHNPQVKKKLYEEIDQNVGFSRTP-TISDRNRLLLLEATIREVLRLRPVAPMLIPH 373
Query: 377 KLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFL-PENTQ-NRHYYS 434
K N D +I + + GT V+I + LH K + P+ F P+ FL P TQ S
Sbjct: 374 KANVDSSIG--EFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVS 431
Query: 435 YIPFSAGPRSCVG 447
Y+PF AGPRSC+G
Sbjct: 432 YLPFGAGPRSCIG 444
>BC062997-1|AAH62997.1| 508|Homo sapiens cytochrome P450, family
17, subfamily A, polypeptide 1 protein.
Length = 508
Score = 92.3 bits (219), Expect = 4e-18
Identities = 75/253 (29%), Positives = 122/253 (48%), Gaps = 18/253 (7%)
Query: 208 VIKNKKETYLENKAKGIIP---PTLEEFTHHSGEILANNAKTLSDT---VFKGYRDDLDF 261
VI+N E ++N +K + P L+ F + + E L ++ K +D + + Y++ F
Sbjct: 197 VIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEK--F 254
Query: 262 NDENDVGEKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFV 317
++ L + ++ G ++ +SD+ I + I G +TT + +
Sbjct: 255 RSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWT 314
Query: 318 LCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IAR 376
L L + V+ ++Y+E+ Q G S P T +D + LE I E LRL P P+ I
Sbjct: 315 LAFLLHNPQVKKKLYEEIDQNVGFSRTP-TISDRNRLLLLEATIREVLRLRPVAPMLIPH 373
Query: 377 KLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFL-PENTQ-NRHYYS 434
K N D +I + + GT V+I + LH K + P+ F P+ FL P TQ S
Sbjct: 374 KANVDSSIG--EFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVS 431
Query: 435 YIPFSAGPRSCVG 447
Y+PF AGPRSC+G
Sbjct: 432 YLPFGAGPRSCIG 444
>AL358790-3|CAI52498.1| 508|Homo sapiens cytochrome P450, family
17, subfamily A, polypeptide 1 protein.
Length = 508
Score = 92.3 bits (219), Expect = 4e-18
Identities = 75/253 (29%), Positives = 122/253 (48%), Gaps = 18/253 (7%)
Query: 208 VIKNKKETYLENKAKGIIP---PTLEEFTHHSGEILANNAKTLSDT---VFKGYRDDLDF 261
VI+N E ++N +K + P L+ F + + E L ++ K +D + + Y++ F
Sbjct: 197 VIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEK--F 254
Query: 262 NDENDVGEKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFV 317
++ L + ++ G ++ +SD+ I + I G +TT + +
Sbjct: 255 RSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWT 314
Query: 318 LCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IAR 376
L L + V+ ++Y+E+ Q G S P T +D + LE I E LRL P P+ I
Sbjct: 315 LAFLLHNPQVKKKLYEEIDQNVGFSRTP-TISDRNRLLLLEATIREVLRLRPVAPMLIPH 373
Query: 377 KLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFL-PENTQ-NRHYYS 434
K N D +I + + GT V+I + LH K + P+ F P+ FL P TQ S
Sbjct: 374 KANVDSSIG--EFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVS 431
Query: 435 YIPFSAGPRSCVG 447
Y+PF AGPRSC+G
Sbjct: 432 YLPFGAGPRSCIG 444
>AK097373-1|BAC05026.1| 340|Homo sapiens protein ( Homo sapiens
cDNA FLJ40054 fis, clone TBAES2000315, weakly similar to
CYTOCHROME P450 4A1 (EC 1.14.15.3). ).
Length = 340
Score = 91.9 bits (218), Expect = 5e-18
Identities = 53/195 (27%), Positives = 103/195 (52%), Gaps = 4/195 (2%)
Query: 31 IRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKPWLGEGLLISSGPKWRSHRKM 90
+ +W+G + F + D IL A ++ + W+G GL+ G KW+ HR++
Sbjct: 80 VPLWVGPFTMFFNIHDPDYVKILLKRQDPKSAVSHKILESWVGRGLVTLDGSKWKKHRQI 139
Query: 91 IAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGKT--FDVHDYMSGTTVDILLETAMGIS 148
+ P F+I+ILK F+ + +++ ++ K + + + ++ ++S T+D +++ A
Sbjct: 140 VKPGFNISILKIFITMMSKSVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSHQ 199
Query: 149 RKTQDESGFD-YAMAVMKMCDIIHQRHYKFWMRSEIVFKLTSFFKQQTKLLGIIHGLTNK 207
Q +S D Y AV + I +QR F +++VFK +S + +K +H T K
Sbjct: 200 GSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFTEK 259
Query: 208 VIKNKKETYLENKAK 222
VI+++KE+ L++K K
Sbjct: 260 VIQDRKES-LKDKLK 273
Score = 52.4 bits (120), Expect = 4e-06
Identities = 24/83 (28%), Positives = 44/83 (53%)
Query: 248 SDTVFKGYRDDLDFNDENDVGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGH 307
++ V + ++ L + D +K+R FLD+++ + T S+ +++ EV T MF GH
Sbjct: 257 TEKVIQDRKESLKDKLKQDTTQKRRQDFLDILLSAKSENTKDFSEADLQAEVKTFMFAGH 316
Query: 308 DTTAAGSSFVLCLLGIHQDVQAR 330
DTT S++ L + + Q R
Sbjct: 317 DTTTTAISWIFYCLAKYPEHQQR 339
>M61854-1|AAB59426.1| 490|Homo sapiens cytochrome protein.
Length = 490
Score = 91.5 bits (217), Expect = 6e-18
Identities = 70/255 (27%), Positives = 115/255 (45%), Gaps = 12/255 (4%)
Query: 226 PPTLEEFTHHSGEILANNAKTLSDTV--FKGYRDDLDFNDENDVGEKKRLAFLDLMIESS 283
P ++ F ++L N A SD + K +++ +D N+ D + FL M +
Sbjct: 220 PTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFID----CFLIKMEKEK 275
Query: 284 QNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSD 343
QN ++ + + ++ G +TT+ + L LL H +V A+V +E+ ++ G +
Sbjct: 276 QNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNR 335
Query: 344 RPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTK--NYVIPAGTTVVIGT 401
P D M Y + V+ E R +P L VT K NY+IP GTT++
Sbjct: 336 SPC-MQDRGHMPYTDAVVHEVQRYIDLIPT---SLPHAVTCDVKFRNYLIPKGTTILTSL 391
Query: 402 FMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXX 461
+ K + +PE+F+P +FL E + ++PFSAG R CVG A
Sbjct: 392 TSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTF 451
Query: 462 XXRNFRTISEIPEKE 476
+NF S I K+
Sbjct: 452 ILQNFNLKSLIDPKD 466
>AF182277-1|AAF13602.1| 491|Homo sapiens cytochrome P450-2B6
protein.
Length = 491
Score = 91.5 bits (217), Expect = 6e-18
Identities = 107/468 (22%), Positives = 184/468 (39%), Gaps = 52/468 (11%)
Query: 16 LVNLALGYAQTFGNVIRVWLGSKLIVFLVDADDI-EIILNSHVHIDKATEYRFFKPWL-G 73
L+ L + + +G+V V LG + +V L + I E +++ + P+ G
Sbjct: 51 LLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRG 110
Query: 74 EGLLISSGPKWRSHRKMIAPTFH-INILKSFVGIFNQNSNN-VVEKLKSEVGKTFDVHDY 131
G++ ++G +W+ R+ T + K V Q ++E+L+ G D
Sbjct: 111 YGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERTQEEAQCLIEELRKSKGALMDATFL 170
Query: 132 MSGTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSEIVFKLTSFF 191
T +I+ G QD+ +KM ++ +Q F + S + +L F
Sbjct: 171 FHSITANIICSIVFGKRFHYQDQE-------FLKMLNLFYQT---FSLISSVFGQLFELF 220
Query: 192 KQQTKLLGIIHGLTNKVIKNKKETYLENKAKGIIPPTLEEFTHHSGEILANNAKTLSDTV 251
+ L G +V KN P + + HS E
Sbjct: 221 ---SGFLKYFPGAHRQVYKN--------------PQEINAYIGHSVE------------- 250
Query: 252 FKGYRDDLDFNDENDVGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTA 311
+R+ LD + D+ + +L M + N ++ S + ++ F G +TT+
Sbjct: 251 --KHRETLDPSAPRDLID----TYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTS 304
Query: 312 AGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPV 371
+ L+ + V RVY E+ Q+ G RP D +M Y E VI E R +
Sbjct: 305 TTLRYGFLLMLKYPHVAERVYREIEQVIGPH-RPPELHDRAKMPYTEAVIYEIQRFSDLL 363
Query: 372 PVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRH 431
P+ + T S + Y+IP T V + P Y++ P+ FNPD+FL N +
Sbjct: 364 PMGVPHIVTQHT-SFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKK 422
Query: 432 YYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKL 479
++IPFS G R C+G A +NF S + ++ L
Sbjct: 423 TEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDL 470
>X13930-1|CAA32118.1| 494|Homo sapiens protein ( Human CYP2A4 mRNA
for P-450 IIA4 protein. ).
Length = 494
Score = 91.1 bits (216), Expect = 8e-18
Identities = 56/204 (27%), Positives = 99/204 (48%), Gaps = 4/204 (1%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
+FL M E +N + + + G +T + + LL H +V+A+V++
Sbjct: 270 SFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHE 329
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ ++ G + +P F D +M Y+E VI E R +P+ +AR++ +D +++ +P
Sbjct: 330 EIDRVIGKNRQPK-FEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKF--RDFFLP 386
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAX 452
GT V + R P ++ +P+ FNP +FL E Q + +++PFS G R+C G A
Sbjct: 387 KGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLAR 446
Query: 453 XXXXXXXXXXXRNFRTISEIPEKE 476
+NFR S K+
Sbjct: 447 MELFLFFTTVMQNFRLKSSQSPKD 470
Score = 35.5 bits (78), Expect = 0.44
Identities = 30/129 (23%), Positives = 58/129 (44%), Gaps = 13/129 (10%)
Query: 13 TQKLVNLALGYAQTFGNVIRVWLGSKLIVFLVDADDI-EIILNSHVHIDKATEYRFFKPW 71
T+++ N + ++ +G V + LG + +V L D + E +++ E F W
Sbjct: 51 TEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFD-W 109
Query: 72 L--GEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGKTFDVH 129
+ G G++ S+G + + R+ F I L+ F G+ + E+++ E G D H
Sbjct: 110 VFKGYGVVFSNGERAKQLRR-----FSIATLRDF-GV---GKRGIEERIQEEAGFLIDAH 160
Query: 130 DYMSGTTVD 138
G +D
Sbjct: 161 RGTGGANID 169
>X13929-1|CAA32117.1| 448|Homo sapiens P-450 IIA3 protein (1 is 3rd
base in codon) protein.
Length = 448
Score = 91.1 bits (216), Expect = 8e-18
Identities = 56/204 (27%), Positives = 99/204 (48%), Gaps = 4/204 (1%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
+FL M E +N + + + G +T + + LL H +V+A+V++
Sbjct: 224 SFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHE 283
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ ++ G + +P F D +M Y+E VI E R +P+ +AR++ +D +++ +P
Sbjct: 284 EIDRVIGKNRQPK-FEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKF--RDFFLP 340
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAX 452
GT V + R P ++ +P+ FNP +FL E Q + +++PFS G R+C G A
Sbjct: 341 KGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLAR 400
Query: 453 XXXXXXXXXXXRNFRTISEIPEKE 476
+NFR S K+
Sbjct: 401 MELFLFFTTVMQNFRLKSSQSPKD 424
>M33318-1|AAA52067.1| 494|Homo sapiens CYP2A protein.
Length = 494
Score = 91.1 bits (216), Expect = 8e-18
Identities = 56/204 (27%), Positives = 99/204 (48%), Gaps = 4/204 (1%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
+FL M E +N + + + G +T + + LL H +V+A+V++
Sbjct: 270 SFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHE 329
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ ++ G + +P F D +M Y+E VI E R +P+ +AR++ +D +++ +P
Sbjct: 330 EIDRVIGKNRQPK-FEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKF--RDFFLP 386
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAX 452
GT V + R P ++ +P+ FNP +FL E Q + +++PFS G R+C G A
Sbjct: 387 KGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLAR 446
Query: 453 XXXXXXXXXXXRNFRTISEIPEKE 476
+NFR S K+
Sbjct: 447 MELFLFFTTVMQNFRLKSSQSPKD 470
>L07093-1|AAA36660.1| 468|Homo sapiens cytochrome P450 protein.
Length = 468
Score = 91.1 bits (216), Expect = 8e-18
Identities = 70/255 (27%), Positives = 115/255 (45%), Gaps = 12/255 (4%)
Query: 226 PPTLEEFTHHSGEILANNAKTLSDTV--FKGYRDDLDFNDENDVGEKKRLAFLDLMIESS 283
P ++ F ++L N A SD + K +++ +D N+ D + FL M +
Sbjct: 198 PTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFID----CFLIKMEKEK 253
Query: 284 QNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSD 343
QN ++ + + ++ G +TT+ + L LL H +V A+V +E+ ++ G +
Sbjct: 254 QNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNR 313
Query: 344 RPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTK--NYVIPAGTTVVIGT 401
P D M Y + V+ E R +P L VT K NY+IP GTT++
Sbjct: 314 SPC-MQDRGHMPYTDAVVHEVQRYIDLIPT---SLPHAVTCDVKFRNYLIPKGTTILTSL 369
Query: 402 FMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXX 461
+ K + +PE+F+P +FL E + ++PFSAG R CVG A
Sbjct: 370 TSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTF 429
Query: 462 XXRNFRTISEIPEKE 476
+NF S I K+
Sbjct: 430 ILQNFNLKSLIDPKD 444
>BC100982-1|AAI00983.1| 280|Homo sapiens CYP3A43 protein protein.
Length = 280
Score = 91.1 bits (216), Expect = 8e-18
Identities = 49/159 (30%), Positives = 88/159 (55%), Gaps = 7/159 (4%)
Query: 266 DVGEKKRLAFLDLMIESSQNGTNK----ISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLL 321
++G + R+ F +I+S + K +SD E+ + I+F +DTT+ F++ L
Sbjct: 122 ELGLQHRVDFFQQIIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYEL 181
Query: 322 GIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRD 381
H DVQ ++ +E+ + + P T+ ++M+YL+ V+ E+LRL+P V + R +D
Sbjct: 182 ATHPDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKD 240
Query: 382 VTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPD 420
+ I+ IP G V++ + LH PKY+ +PE F P+
Sbjct: 241 IEIN--GVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPE 277
>BC096256-1|AAH96256.1| 494|Homo sapiens cytochrome P450, family 2,
subfamily A, polypeptide 6 protein.
Length = 494
Score = 91.1 bits (216), Expect = 8e-18
Identities = 56/204 (27%), Positives = 99/204 (48%), Gaps = 4/204 (1%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
+FL M E +N + + + G +T + + LL H +V+A+V++
Sbjct: 270 SFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHE 329
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ ++ G + +P F D +M Y+E VI E R +P+ +AR++ +D +++ +P
Sbjct: 330 EIDRVIGKNRQPK-FEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKF--RDFFLP 386
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAX 452
GT V + R P ++ +P+ FNP +FL E Q + +++PFS G R+C G A
Sbjct: 387 KGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLAR 446
Query: 453 XXXXXXXXXXXRNFRTISEIPEKE 476
+NFR S K+
Sbjct: 447 MELFLFFTTVMQNFRLKSSQSPKD 470
>BC096255-1|AAH96255.1| 494|Homo sapiens cytochrome P450, family 2,
subfamily A, polypeptide 6 protein.
Length = 494
Score = 91.1 bits (216), Expect = 8e-18
Identities = 56/204 (27%), Positives = 99/204 (48%), Gaps = 4/204 (1%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
+FL M E +N + + + G +T + + LL H +V+A+V++
Sbjct: 270 SFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHE 329
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ ++ G + +P F D +M Y+E VI E R +P+ +AR++ +D +++ +P
Sbjct: 330 EIDRVIGKNRQPK-FEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKF--RDFFLP 386
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAX 452
GT V + R P ++ +P+ FNP +FL E Q + +++PFS G R+C G A
Sbjct: 387 KGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLAR 446
Query: 453 XXXXXXXXXXXRNFRTISEIPEKE 476
+NFR S K+
Sbjct: 447 MELFLFFTTVMQNFRLKSSQSPKD 470
Score = 35.5 bits (78), Expect = 0.44
Identities = 30/129 (23%), Positives = 58/129 (44%), Gaps = 13/129 (10%)
Query: 13 TQKLVNLALGYAQTFGNVIRVWLGSKLIVFLVDADDI-EIILNSHVHIDKATEYRFFKPW 71
T+++ N + ++ +G V + LG + +V L D + E +++ E F W
Sbjct: 51 TEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFD-W 109
Query: 72 L--GEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGKTFDVH 129
+ G G++ S+G + + R+ F I L+ F G+ + E+++ E G D H
Sbjct: 110 VFKGYGVVFSNGERAKQLRR-----FSIATLRDF-GV---GKRGIEERIQEEAGFLIDAH 160
Query: 130 DYMSGTTVD 138
G +D
Sbjct: 161 RGTGGANID 169
>BC096254-1|AAH96254.1| 494|Homo sapiens cytochrome P450, family 2,
subfamily A, polypeptide 6 protein.
Length = 494
Score = 91.1 bits (216), Expect = 8e-18
Identities = 56/204 (27%), Positives = 99/204 (48%), Gaps = 4/204 (1%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
+FL M E +N + + + G +T + + LL H +V+A+V++
Sbjct: 270 SFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHE 329
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ ++ G + +P F D +M Y+E VI E R +P+ +AR++ +D +++ +P
Sbjct: 330 EIDRVIGKNRQPK-FEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKF--RDFFLP 386
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAX 452
GT V + R P ++ +P+ FNP +FL E Q + +++PFS G R+C G A
Sbjct: 387 KGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLAR 446
Query: 453 XXXXXXXXXXXRNFRTISEIPEKE 476
+NFR S K+
Sbjct: 447 MELFLFFTTVMQNFRLKSSQSPKD 470
>BC096253-1|AAH96253.3| 494|Homo sapiens cytochrome P450, family 2,
subfamily A, polypeptide 6 protein.
Length = 494
Score = 91.1 bits (216), Expect = 8e-18
Identities = 56/204 (27%), Positives = 99/204 (48%), Gaps = 4/204 (1%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
+FL M E +N + + + G +T + + LL H +V+A+V++
Sbjct: 270 SFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHE 329
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ ++ G + +P F D +M Y+E VI E R +P+ +AR++ +D +++ +P
Sbjct: 330 EIDRVIGKNRQPK-FEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKF--RDFFLP 386
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAX 452
GT V + R P ++ +P+ FNP +FL E Q + +++PFS G R+C G A
Sbjct: 387 KGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLAR 446
Query: 453 XXXXXXXXXXXRNFRTISEIPEKE 476
+NFR S K+
Sbjct: 447 MELFLFFTTVMQNFRLKSSQSPKD 470
>BC067430-1|AAH67430.1| 491|Homo sapiens cytochrome P450, family 2,
subfamily B, polypeptide 6 protein.
Length = 491
Score = 91.1 bits (216), Expect = 8e-18
Identities = 105/468 (22%), Positives = 185/468 (39%), Gaps = 52/468 (11%)
Query: 16 LVNLALGYAQTFGNVIRVWLGSKLIVFLVDADDI-EIILNSHVHIDKATEYRFFKPWL-G 73
L+ L + + +G+V V LG + +V L + I E +++ + P+ G
Sbjct: 51 LLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRG 110
Query: 74 EGLLISSGPKWRSHRKMIAPTFHINIL--KSFVGIFNQNSNNVVEKLKSEVGKTFDVHDY 131
G++ ++G +W+ R+ T + +S + + ++E+L+ G D
Sbjct: 111 YGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFL 170
Query: 132 MSGTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSEIVFKLTSFF 191
T +I+ G QD+ +KM ++ +Q F + S + +L F
Sbjct: 171 FHSITANIICSIVFGKRFHYQDQE-------FLKMLNLFYQT---FSLISSVFGQLFELF 220
Query: 192 KQQTKLLGIIHGLTNKVIKNKKETYLENKAKGIIPPTLEEFTHHSGEILANNAKTLSDTV 251
+ L G +V KN L+E + G + + +TL +
Sbjct: 221 ---SGFLKYFPGAHRQVYKN-----------------LQEINAYIGHSVEKHRETLDPSA 260
Query: 252 FKGYRDDLDFNDENDVGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTA 311
RD +D +L M + N ++ S + ++ F G +TT+
Sbjct: 261 ---PRDLID-------------TYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTS 304
Query: 312 AGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPV 371
+ L+ + V RVY E+ Q+ G RP D +M Y E VI E R +
Sbjct: 305 TTLRYGFLLMLKYPHVAERVYREIEQVIGPH-RPPELHDRAKMPYTEAVIYEIQRFSDLL 363
Query: 372 PVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRH 431
P+ + T S + Y+IP T V + P Y++ P+ FNPD+FL N +
Sbjct: 364 PMGVPHIVTQHT-SFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKK 422
Query: 432 YYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKL 479
++IPFS G R C+G A +NF S + ++ L
Sbjct: 423 TEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDL 470
>AY796203-1|AAV41877.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 19 protein.
Length = 490
Score = 91.1 bits (216), Expect = 8e-18
Identities = 70/255 (27%), Positives = 115/255 (45%), Gaps = 12/255 (4%)
Query: 226 PPTLEEFTHHSGEILANNAKTLSDTV--FKGYRDDLDFNDENDVGEKKRLAFLDLMIESS 283
P ++ F ++L N A SD + K +++ +D N+ D + FL M +
Sbjct: 220 PTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFID----CFLIKMEKEK 275
Query: 284 QNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSD 343
QN ++ + + ++ G +TT+ + L LL H +V A+V +E+ ++ G +
Sbjct: 276 QNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNR 335
Query: 344 RPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTK--NYVIPAGTTVVIGT 401
P D M Y + V+ E R +P L VT K NY+IP GTT++
Sbjct: 336 SPC-MQDRGHMPYTDAVVHEVQRYIDLIPT---SLPHAVTCDVKFRNYLIPKGTTILTSL 391
Query: 402 FMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXX 461
+ K + +PE+F+P +FL E + ++PFSAG R CVG A
Sbjct: 392 TSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTF 451
Query: 462 XXRNFRTISEIPEKE 476
+NF S I K+
Sbjct: 452 ILQNFNLKSLIDPKD 466
>AL583836-2|CAH74068.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 19 protein.
Length = 490
Score = 91.1 bits (216), Expect = 8e-18
Identities = 70/255 (27%), Positives = 115/255 (45%), Gaps = 12/255 (4%)
Query: 226 PPTLEEFTHHSGEILANNAKTLSDTV--FKGYRDDLDFNDENDVGEKKRLAFLDLMIESS 283
P ++ F ++L N A SD + K +++ +D N+ D + FL M +
Sbjct: 220 PTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFID----CFLIKMEKEK 275
Query: 284 QNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSD 343
QN ++ + + ++ G +TT+ + L LL H +V A+V +E+ ++ G +
Sbjct: 276 QNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNR 335
Query: 344 RPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTK--NYVIPAGTTVVIGT 401
P D M Y + V+ E R +P L VT K NY+IP GTT++
Sbjct: 336 SPC-MQDRGHMPYTDAVVHEVQRYIDLIPT---SLPHAVTCDVKFRNYLIPKGTTILTSL 391
Query: 402 FMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXX 461
+ K + +PE+F+P +FL E + ++PFSAG R CVG A
Sbjct: 392 TSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTF 451
Query: 462 XXRNFRTISEIPEKE 476
+NF S I K+
Sbjct: 452 ILQNFNLKSLIDPKD 466
>AL133513-2|CAH73444.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 19 protein.
Length = 490
Score = 91.1 bits (216), Expect = 8e-18
Identities = 70/255 (27%), Positives = 115/255 (45%), Gaps = 12/255 (4%)
Query: 226 PPTLEEFTHHSGEILANNAKTLSDTV--FKGYRDDLDFNDENDVGEKKRLAFLDLMIESS 283
P ++ F ++L N A SD + K +++ +D N+ D + FL M +
Sbjct: 220 PTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFID----CFLIKMEKEK 275
Query: 284 QNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSD 343
QN ++ + + ++ G +TT+ + L LL H +V A+V +E+ ++ G +
Sbjct: 276 QNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNR 335
Query: 344 RPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTK--NYVIPAGTTVVIGT 401
P D M Y + V+ E R +P L VT K NY+IP GTT++
Sbjct: 336 SPC-MQDRGHMPYTDAVVHEVQRYIDLIPT---SLPHAVTCDVKFRNYLIPKGTTILTSL 391
Query: 402 FMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXX 461
+ K + +PE+F+P +FL E + ++PFSAG R CVG A
Sbjct: 392 TSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTF 451
Query: 462 XXRNFRTISEIPEKE 476
+NF S I K+
Sbjct: 452 ILQNFNLKSLIDPKD 466
>AF182275-1|AAF13600.1| 494|Homo sapiens cytochrome P450-2A6
protein.
Length = 494
Score = 91.1 bits (216), Expect = 8e-18
Identities = 56/204 (27%), Positives = 99/204 (48%), Gaps = 4/204 (1%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
+FL M E +N + + + G +T + + LL H +V+A+V++
Sbjct: 270 SFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHE 329
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ ++ G + +P F D +M Y+E VI E R +P+ +AR++ +D +++ +P
Sbjct: 330 EIDRVIGKNRQPK-FEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKF--RDFFLP 386
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAX 452
GT V + R P ++ +P+ FNP +FL E Q + +++PFS G R+C G A
Sbjct: 387 KGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLAR 446
Query: 453 XXXXXXXXXXXRNFRTISEIPEKE 476
+NFR S K+
Sbjct: 447 MELFLFFTTVMQNFRLKSSQSPKD 470
>X13897-1|CAA32097.1| 489|Homo sapiens protein ( Human mRNA for
cytochrome P-450IIA. ).
Length = 489
Score = 90.6 bits (215), Expect = 1e-17
Identities = 56/204 (27%), Positives = 99/204 (48%), Gaps = 4/204 (1%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
+FL M E +N + + + G +T + + LL H +V+A+V++
Sbjct: 265 SFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAQVHE 324
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ ++ G + +P F D +M Y+E VI E R +P+ +AR++ +D +++ +P
Sbjct: 325 EIDRVIGKNRQPK-FEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKF--RDFFLP 381
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAX 452
GT V + R P ++ +P+ FNP +FL E Q + +++PFS G R+C G A
Sbjct: 382 KGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLAR 441
Query: 453 XXXXXXXXXXXRNFRTISEIPEKE 476
+NFR S K+
Sbjct: 442 MELFLFFTTVMQNFRLKSSQSPKD 465
>M61858-1|AAA52145.1| 370|Homo sapiens CYP2C17 protein.
Length = 370
Score = 90.6 bits (215), Expect = 1e-17
Identities = 75/258 (29%), Positives = 118/258 (45%), Gaps = 21/258 (8%)
Query: 228 TLEEFTHHSGEILANNAKTLSDTVF---KGYRDDLDFNDENDVGEKKRLAFLD-LMIESS 283
T+ ++ S L N TL V K +++ LD N+ D F+D +I+
Sbjct: 101 TIIDYFPGSHNKLLKNLLTLKSYVLERIKEHQESLDMNNPRD--------FIDCFLIKME 152
Query: 284 QNGTNKISDHEIKEEVDTI--MF-EGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFG 340
Q N+ S+ ++ + T+ MF G +TT+ + L LL H +V A+V +E+ ++ G
Sbjct: 153 QEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVG 212
Query: 341 DSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTK--NYVIPAGTTVV 398
+ P D M Y + V+ E R +P L VT K NY+IP GTT++
Sbjct: 213 RNRSPC-MQDRSHMPYTDAVVHEVQRYIDLIPT---SLPHAVTCDVKFRNYLIPKGTTIL 268
Query: 399 IGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXX 458
+ K + +PE+F+P +FL E + ++PFSAG R CVG A
Sbjct: 269 TSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLF 328
Query: 459 XXXXXRNFRTISEIPEKE 476
+NF S I K+
Sbjct: 329 LTFILQNFNLKSLIDPKD 346
>M21939-1|AAA52158.1| 485|Homo sapiens CYP2C protein.
Length = 485
Score = 90.6 bits (215), Expect = 1e-17
Identities = 68/253 (26%), Positives = 114/253 (45%), Gaps = 12/253 (4%)
Query: 227 PTLEEFTHHSGEILANNA--KTLSDTVFKGYRDDLDFNDENDVGEKKRLAFLDLMIESSQ 284
P ++ F ++L N A K+ K +++ +D N+ D + FL M +
Sbjct: 216 PIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFID----CFLMKMEKEKH 271
Query: 285 NGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDR 344
N ++ + ++ + G +TT+ + L LL H +V A+V +E+ ++ G +
Sbjct: 272 NQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRS 331
Query: 345 PATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVT--ISTKNYVIPAGTTVVIGTF 402
P D M Y + V+ E R +P L VT I +NY+IP GTT++I
Sbjct: 332 PC-MQDRSHMPYTDAVVHEVQRCIDLLPT---SLPHAVTCDIKFRNYLIPKGTTILISLT 387
Query: 403 MLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXX 462
+ K + +PE+F+P +FL E + ++PFSAG R CVG A
Sbjct: 388 SVLHDNKEFPNPEMFDPHHFLDEGDNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSI 447
Query: 463 XRNFRTISEIPEK 475
+NF S + K
Sbjct: 448 LQNFNLKSLVDPK 460
>M15331-1|AAA52157.1| 485|Homo sapiens CYP2C protein.
Length = 485
Score = 90.6 bits (215), Expect = 1e-17
Identities = 68/253 (26%), Positives = 114/253 (45%), Gaps = 12/253 (4%)
Query: 227 PTLEEFTHHSGEILANNA--KTLSDTVFKGYRDDLDFNDENDVGEKKRLAFLDLMIESSQ 284
P ++ F ++L N A K+ K +++ +D N+ D + FL M +
Sbjct: 216 PIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFID----CFLMKMEKEKH 271
Query: 285 NGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDR 344
N ++ + ++ + G +TT+ + L LL H +V A+V +E+ ++ G +
Sbjct: 272 NQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRS 331
Query: 345 PATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVT--ISTKNYVIPAGTTVVIGTF 402
P D M Y + V+ E R +P L VT I +NY+IP GTT++I
Sbjct: 332 PC-MQDRSHMPYTDAVVHEVQRCIDLLPT---SLPHAVTCDIKFRNYLIPKGTTILISLT 387
Query: 403 MLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXX 462
+ K + +PE+F+P +FL E + ++PFSAG R CVG A
Sbjct: 388 SVLHDNKEFPNPEMFDPHHFLDEGDNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSI 447
Query: 463 XRNFRTISEIPEK 475
+NF S + K
Sbjct: 448 LQNFNLKSLVDPK 460
>AJ563378-3|CAD91347.1| 173|Homo sapiens hypothetical protein
protein.
Length = 173
Score = 90.6 bits (215), Expect = 1e-17
Identities = 51/156 (32%), Positives = 82/156 (52%), Gaps = 6/156 (3%)
Query: 345 PATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFML 404
P T+ ++M+YL+ V+ E+LRL+P + R +DV I+ IP G+ VVI T+ L
Sbjct: 15 PPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEIN--GVFIPKGSMVVIPTYAL 72
Query: 405 HRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXR 464
H PKY+ +PE F P+ F + + Y Y PF GPR+C+G ++A +
Sbjct: 73 HHDPKYWTEPEEFRPERF-SKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQ 131
Query: 465 NFRTISEIPEKEFKLQGDI--ILKRAEGFQMKVEPR 498
NF + E + L+ D +L+ + +KV+ R
Sbjct: 132 NF-SFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSR 166
>AJ563378-2|CAD91647.1| 160|Homo sapiens cytochrome P450 protein.
Length = 160
Score = 90.6 bits (215), Expect = 1e-17
Identities = 51/156 (32%), Positives = 82/156 (52%), Gaps = 6/156 (3%)
Query: 345 PATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFML 404
P T+ ++M+YL+ V+ E+LRL+P + R +DV I+ IP G+ VVI T+ L
Sbjct: 2 PPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEIN--GVFIPKGSMVVIPTYAL 59
Query: 405 HRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXR 464
H PKY+ +PE F P+ F + + Y Y PF GPR+C+G ++A +
Sbjct: 60 HHDPKYWTEPEEFRPERF-SKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQ 118
Query: 465 NFRTISEIPEKEFKLQGDI--ILKRAEGFQMKVEPR 498
NF + E + L+ D +L+ + +KV+ R
Sbjct: 119 NF-SFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSR 153
>S46963-1|AAB23864.2| 477|Homo sapiens cytochrome P-450 protein.
Length = 477
Score = 90.2 bits (214), Expect = 1e-17
Identities = 68/253 (26%), Positives = 114/253 (45%), Gaps = 12/253 (4%)
Query: 227 PTLEEFTHHSGEILANNA--KTLSDTVFKGYRDDLDFNDENDVGEKKRLAFLDLMIESSQ 284
P ++ F ++L N A K+ K +++ +D N+ D + FL M +
Sbjct: 208 PIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFID----CFLMKMEKEKH 263
Query: 285 NGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDR 344
N ++ + ++ + G +TT+ + L LL H +V A+V +E+ ++ G +
Sbjct: 264 NQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRS 323
Query: 345 PATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVT--ISTKNYVIPAGTTVVIGTF 402
P D M Y + V+ E R +P L VT I +NY+IP GTT++I
Sbjct: 324 PC-MQDRSHMPYTDAVVHEVQRYIDLLPT---SLPHAVTCDIKFRNYLIPKGTTILISLT 379
Query: 403 MLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXX 462
+ K + +PE+F+P +FL E + ++PFSAG R CVG A
Sbjct: 380 SVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSI 439
Query: 463 XRNFRTISEIPEK 475
+NF S + K
Sbjct: 440 LQNFNLKSLVDPK 452
>M21940-1|AAA52159.1| 383|Homo sapiens CYP2C protein.
Length = 383
Score = 90.2 bits (214), Expect = 1e-17
Identities = 68/253 (26%), Positives = 114/253 (45%), Gaps = 12/253 (4%)
Query: 227 PTLEEFTHHSGEILANNA--KTLSDTVFKGYRDDLDFNDENDVGEKKRLAFLDLMIESSQ 284
P ++ F ++L N A K+ K +++ +D N+ D + FL M +
Sbjct: 114 PIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFID----CFLMKMEKEKH 169
Query: 285 NGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDR 344
N ++ + ++ + G +TT+ + L LL H +V A+V +E+ ++ G +
Sbjct: 170 NQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRS 229
Query: 345 PATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVT--ISTKNYVIPAGTTVVIGTF 402
P D M Y + V+ E R +P L VT I +NY+IP GTT++I
Sbjct: 230 PC-MQDRSHMPYTDAVVHEVQRCIDLLPT---SLPHAVTCDIKFRNYLIPKGTTILISLT 285
Query: 403 MLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXX 462
+ K + +PE+F+P +FL E + ++PFSAG R CVG A
Sbjct: 286 SVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSI 345
Query: 463 XRNFRTISEIPEK 475
+NF S + K
Sbjct: 346 LQNFNLKSLVDPK 358
>D00173-1|BAA00123.1| 487|Homo sapiens cytochrome P-450 protein.
Length = 487
Score = 90.2 bits (214), Expect = 1e-17
Identities = 68/253 (26%), Positives = 114/253 (45%), Gaps = 12/253 (4%)
Query: 227 PTLEEFTHHSGEILANNA--KTLSDTVFKGYRDDLDFNDENDVGEKKRLAFLDLMIESSQ 284
P ++ F ++L N A K+ K +++ +D N+ D + FL M +
Sbjct: 218 PIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFID----CFLMKMEKEKH 273
Query: 285 NGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDR 344
N ++ + ++ + G +TT+ + L LL H +V A+V +E+ ++ G +
Sbjct: 274 NQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRS 333
Query: 345 PATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVT--ISTKNYVIPAGTTVVIGTF 402
P D M Y + V+ E R +P L VT I +NY+IP GTT++I
Sbjct: 334 PC-MQDRSHMPYTDAVVHEVQRYIDLLPT---SLPHAVTCDIKFRNYLIPKGTTILISLT 389
Query: 403 MLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXX 462
+ K + +PE+F+P +FL E + ++PFSAG R CVG A
Sbjct: 390 SVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSI 449
Query: 463 XRNFRTISEIPEK 475
+NF S + K
Sbjct: 450 LQNFNLKSLVDPK 462
>BC125054-1|AAI25055.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 90.2 bits (214), Expect = 1e-17
Identities = 68/253 (26%), Positives = 114/253 (45%), Gaps = 12/253 (4%)
Query: 227 PTLEEFTHHSGEILANNA--KTLSDTVFKGYRDDLDFNDENDVGEKKRLAFLDLMIESSQ 284
P ++ F ++L N A K+ K +++ +D N+ D + FL M +
Sbjct: 221 PIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFID----CFLMKMEKEKH 276
Query: 285 NGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDR 344
N ++ + ++ + G +TT+ + L LL H +V A+V +E+ ++ G +
Sbjct: 277 NQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRS 336
Query: 345 PATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVT--ISTKNYVIPAGTTVVIGTF 402
P D M Y + V+ E R +P L VT I +NY+IP GTT++I
Sbjct: 337 PC-MQDRSHMPYTDAVVHEVQRYIDLLPT---SLPHAVTCDIKFRNYLIPKGTTILISLT 392
Query: 403 MLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXX 462
+ K + +PE+F+P +FL E + ++PFSAG R CVG A
Sbjct: 393 SVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSI 452
Query: 463 XRNFRTISEIPEK 475
+NF S + K
Sbjct: 453 LQNFNLKSLVDPK 465
>BC117165-1|AAI17166.1| 494|Homo sapiens cytochrome P450, family 2,
subfamily A, polypeptide 7 protein.
Length = 494
Score = 90.2 bits (214), Expect = 1e-17
Identities = 55/204 (26%), Positives = 98/204 (48%), Gaps = 4/204 (1%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
+FL M E +N + + + G +T + + LL H +V+A+V++
Sbjct: 270 SFLIRMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHE 329
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ ++ G + +P F D +M Y+E VI E R +P+ +AR++ +D +++ +P
Sbjct: 330 EIDRVIGKNRQPK-FEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKF--RDFFLP 386
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAX 452
GT V + R P ++ +P+ FNP +FL + Q + +++PFS G R C G A
Sbjct: 387 KGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAFVPFSIGKRYCFGEGLAR 446
Query: 453 XXXXXXXXXXXRNFRTISEIPEKE 476
+NFR S K+
Sbjct: 447 MELFLFFTTVMQNFRLKSSQSPKD 470
>AY702706-1|AAT94065.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 90.2 bits (214), Expect = 1e-17
Identities = 68/253 (26%), Positives = 114/253 (45%), Gaps = 12/253 (4%)
Query: 227 PTLEEFTHHSGEILANNA--KTLSDTVFKGYRDDLDFNDENDVGEKKRLAFLDLMIESSQ 284
P ++ F ++L N A K+ K +++ +D N+ D + FL M +
Sbjct: 221 PIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFID----CFLMKMEKEKH 276
Query: 285 NGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDR 344
N ++ + ++ + G +TT+ + L LL H +V A+V +E+ ++ G +
Sbjct: 277 NQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRS 336
Query: 345 PATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVT--ISTKNYVIPAGTTVVIGTF 402
P D M Y + V+ E R +P L VT I +NY+IP GTT++I
Sbjct: 337 PC-MQDRSHMPYTDAVVHEVQRYIDLLPT---SLPHAVTCDIKFRNYLIPKGTTILISLT 392
Query: 403 MLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXX 462
+ K + +PE+F+P +FL E + ++PFSAG R CVG A
Sbjct: 393 SVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSI 452
Query: 463 XRNFRTISEIPEK 475
+NF S + K
Sbjct: 453 LQNFNLKSLVDPK 465
>AY341248-1|AAP88931.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 90.2 bits (214), Expect = 1e-17
Identities = 68/253 (26%), Positives = 114/253 (45%), Gaps = 12/253 (4%)
Query: 227 PTLEEFTHHSGEILANNA--KTLSDTVFKGYRDDLDFNDENDVGEKKRLAFLDLMIESSQ 284
P ++ F ++L N A K+ K +++ +D N+ D + FL M +
Sbjct: 221 PIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFID----CFLMKMEKEKH 276
Query: 285 NGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDR 344
N ++ + ++ + G +TT+ + L LL H +V A+V +E+ ++ G +
Sbjct: 277 NQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRS 336
Query: 345 PATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVT--ISTKNYVIPAGTTVVIGTF 402
P D M Y + V+ E R +P L VT I +NY+IP GTT++I
Sbjct: 337 PC-MQDRSHMPYTDAVVHEVQRYIDLLPT---SLPHAVTCDIKFRNYLIPKGTTILISLT 392
Query: 403 MLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXX 462
+ K + +PE+F+P +FL E + ++PFSAG R CVG A
Sbjct: 393 SVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSI 452
Query: 463 XRNFRTISEIPEK 475
+NF S + K
Sbjct: 453 LQNFNLKSLVDPK 465
>AL359672-1|CAH71303.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 90.2 bits (214), Expect = 1e-17
Identities = 68/253 (26%), Positives = 114/253 (45%), Gaps = 12/253 (4%)
Query: 227 PTLEEFTHHSGEILANNA--KTLSDTVFKGYRDDLDFNDENDVGEKKRLAFLDLMIESSQ 284
P ++ F ++L N A K+ K +++ +D N+ D + FL M +
Sbjct: 221 PIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFID----CFLMKMEKEKH 276
Query: 285 NGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDR 344
N ++ + ++ + G +TT+ + L LL H +V A+V +E+ ++ G +
Sbjct: 277 NQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRS 336
Query: 345 PATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVT--ISTKNYVIPAGTTVVIGTF 402
P D M Y + V+ E R +P L VT I +NY+IP GTT++I
Sbjct: 337 PC-MQDRSHMPYTDAVVHEVQRYIDLLPT---SLPHAVTCDIKFRNYLIPKGTTILISLT 392
Query: 403 MLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXX 462
+ K + +PE+F+P +FL E + ++PFSAG R CVG A
Sbjct: 393 SVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSI 452
Query: 463 XRNFRTISEIPEK 475
+NF S + K
Sbjct: 453 LQNFNLKSLVDPK 465
>M33317-1|AAA52138.1| 494|Homo sapiens CYP2A protein.
Length = 494
Score = 89.8 bits (213), Expect = 2e-17
Identities = 55/204 (26%), Positives = 98/204 (48%), Gaps = 4/204 (1%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
+FL M E +N + + + G +T + + LL H +V+A+V++
Sbjct: 270 SFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHE 329
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ ++ G + +P F D +M Y+E VI E R +P+ +AR++ +D +++ +P
Sbjct: 330 EIDRVIGKNRQPK-FEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKF--RDFFLP 386
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAX 452
GT V + R P ++ +P+ FNP +FL + Q + +++PFS G R C G A
Sbjct: 387 KGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAFVPFSIGKRYCFGEGLAR 446
Query: 453 XXXXXXXXXXXRNFRTISEIPEKE 476
+NFR S K+
Sbjct: 447 MELFLFFTTVMQNFRLKSSQSPKD 470
>BC033691-1|AAH33691.1| 504|Homo sapiens cytochrome P450, family 2,
subfamily S, polypeptide 1 protein.
Length = 504
Score = 89.4 bits (212), Expect = 3e-17
Identities = 68/229 (29%), Positives = 106/229 (46%), Gaps = 10/229 (4%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
AFL M + QN + ++ + V ++F G T + + L LL + VQ V +
Sbjct: 271 AFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVRE 330
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
EL + G P+ D + Y + V+ E+ RL VP+ I R L R T + Y +P
Sbjct: 331 ELNRELGAGQAPS-LGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMR--TTRFRGYTLP 387
Query: 393 AGTTV--VIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKY 450
GT V ++G+ +LH P +K PE FNPD FL + + R + +++PFS G R C+G
Sbjct: 388 QGTEVFPLLGS-ILH-DPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGL 445
Query: 451 AXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDI--ILKRAEGFQMKVEP 497
A + F S P L+ + + FQ++V P
Sbjct: 446 AKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPAFQLQVRP 494
>AY358603-1|AAQ88966.1| 504|Homo sapiens Cytochrome p450 protein.
Length = 504
Score = 89.4 bits (212), Expect = 3e-17
Identities = 68/229 (29%), Positives = 106/229 (46%), Gaps = 10/229 (4%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
AFL M + QN + ++ + V ++F G T + + L LL + VQ V +
Sbjct: 271 AFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVRE 330
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
EL + G P+ D + Y + V+ E+ RL VP+ I R L R T + Y +P
Sbjct: 331 ELNRELGAGQAPS-LGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMR--TTRFRGYTLP 387
Query: 393 AGTTV--VIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKY 450
GT V ++G+ +LH P +K PE FNPD FL + + R + +++PFS G R C+G
Sbjct: 388 QGTEVFPLLGS-ILH-DPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGL 445
Query: 451 AXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDI--ILKRAEGFQMKVEP 497
A + F S P L+ + + FQ++V P
Sbjct: 446 AKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPAFQLQVRP 494
>AF335278-1|AAK13498.1| 504|Homo sapiens cytochrome P450 2S1
protein.
Length = 504
Score = 89.4 bits (212), Expect = 3e-17
Identities = 68/229 (29%), Positives = 106/229 (46%), Gaps = 10/229 (4%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
AFL M + QN + ++ + V ++F G T + + L LL + VQ V +
Sbjct: 271 AFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVRE 330
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
EL + G P+ D + Y + V+ E+ RL VP+ I R L R T + Y +P
Sbjct: 331 ELNRELGAGQAPS-LGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMR--TTRFRGYTLP 387
Query: 393 AGTTV--VIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKY 450
GT V ++G+ +LH P +K PE FNPD FL + + R + +++PFS G R C+G
Sbjct: 388 QGTEVFPLLGS-ILH-DPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGL 445
Query: 451 AXXXXXXXXXXXXRNFRTISEIPEKEFKLQGDI--ILKRAEGFQMKVEP 497
A + F S P L+ + + FQ++V P
Sbjct: 446 AKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPAFQLQVRP 494
>M29874-1|AAA52144.1| 491|Homo sapiens CYP2B protein.
Length = 491
Score = 89.0 bits (211), Expect = 3e-17
Identities = 97/466 (20%), Positives = 183/466 (39%), Gaps = 48/466 (10%)
Query: 16 LVNLALGYAQTFGNVIRVWLGSKLIVFLVDADDI-EIILNSHVHIDKATEYRFFKPWL-G 73
L+ L + + +G+V V LG + +V L + I E +++ + P+ G
Sbjct: 51 LLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRG 110
Query: 74 EGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGKTFDVHDYMS 133
G++ ++G +W+ R+ F + ++ F +V E+++ E
Sbjct: 111 YGVIFANGNRWKVLRR-----FSVTTMRDF----GMGKRSVEERIQEEA----------- 150
Query: 134 GTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSEIVFKLTSFFKQ 193
L+E D + ++ +C I+ + + + + + K+ + F Q
Sbjct: 151 ----QCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHY--QDQEFLKMLNLFYQ 204
Query: 194 QTKLLGIIHGLTNKVIKNKKETYLENKAKGIIPPTLEEFTHHSGEILANNAKTLSDTVFK 253
L+ + G ++ + Y + + L+E + G + + +TL + K
Sbjct: 205 TFSLISSVFGQLFELFSGFLK-YFPGAHRQVYK-NLQEINAYIGHSVEKHRETLDPSAPK 262
Query: 254 GYRDDLDFNDENDVGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAG 313
D +L M + N ++ S + ++ F G +TT+
Sbjct: 263 DLID----------------TYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTT 306
Query: 314 SSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV 373
+ L+ + V RVY E+ Q+ G RP D +M Y E VI E R +P+
Sbjct: 307 LRYGFLLMLKYPHVAERVYREIEQVIGPH-RPPELHDRAKMPYTEAVIYEIQRFSDLLPM 365
Query: 374 IARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYY 433
+ T S + Y+IP T V + P Y++ P+ FNPD+FL N +
Sbjct: 366 GVPHIVTQHT-SFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTE 424
Query: 434 SYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKL 479
++IPFS G R C+G A +NF S + ++ L
Sbjct: 425 AFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDL 470
>DQ298753-1|ABB84469.1| 491|Homo sapiens cytochrome P450, family 2,
subfamily B, polypeptide 6 protein.
Length = 491
Score = 89.0 bits (211), Expect = 3e-17
Identities = 97/466 (20%), Positives = 183/466 (39%), Gaps = 48/466 (10%)
Query: 16 LVNLALGYAQTFGNVIRVWLGSKLIVFLVDADDI-EIILNSHVHIDKATEYRFFKPWL-G 73
L+ L + + +G+V V LG + +V L + I E +++ + P+ G
Sbjct: 51 LLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRG 110
Query: 74 EGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGKTFDVHDYMS 133
G++ ++G +W+ R+ F + ++ F +V E+++ E
Sbjct: 111 YGVIFANGNRWKVLRR-----FSVTTMRDF----GMGKRSVEERIQEEA----------- 150
Query: 134 GTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSEIVFKLTSFFKQ 193
L+E D + ++ +C I+ + + + + + K+ + F Q
Sbjct: 151 ----QCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHY--QDQEFLKMLNLFYQ 204
Query: 194 QTKLLGIIHGLTNKVIKNKKETYLENKAKGIIPPTLEEFTHHSGEILANNAKTLSDTVFK 253
L+ + G ++ + Y + + L+E + G + + +TL + K
Sbjct: 205 TFSLISSVFGQLFELFSGFLK-YFPGAHRQVYK-NLQEINAYIGHSVEKHRETLDPSAPK 262
Query: 254 GYRDDLDFNDENDVGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAG 313
D +L M + N ++ S + ++ F G +TT+
Sbjct: 263 DLID----------------TYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTT 306
Query: 314 SSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV 373
+ L+ + V RVY E+ Q+ G RP D +M Y E VI E R +P+
Sbjct: 307 LRYGFLLMLKYPHVAERVYREIEQVIGPH-RPPELHDRAKMPYTEAVIYEIQRFSDLLPM 365
Query: 374 IARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYY 433
+ T S + Y+IP T V + P Y++ P+ FNPD+FL N +
Sbjct: 366 GVPHIVTQHT-SFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTE 424
Query: 434 SYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKL 479
++IPFS G R C+G A +NF S + ++ L
Sbjct: 425 AFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDL 470
>AY696295-1|AAU10524.1| 292|Homo sapiens cytochrome P450 protein.
Length = 292
Score = 89.0 bits (211), Expect = 3e-17
Identities = 52/195 (26%), Positives = 102/195 (52%), Gaps = 4/195 (2%)
Query: 31 IRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKPWLGEGLLISSGPKWRSHRKM 90
+ +W+G + F + D IL + A ++ + W+G GL+ G KW+ HR++
Sbjct: 80 VPLWVGPFTMFFNIHDPDYVKILLKRQNPKSAVSHKILESWVGRGLVTLDGSKWKKHRQI 139
Query: 91 IAPTFHINILKSFVGIFNQNSNNVVEKLKSEV--GKTFDVHDYMSGTTVDILLETAMGIS 148
+ P F+I+ILK F+ + +++ ++ K + + ++ ++S T+ +++ A
Sbjct: 140 VKPGFNISILKIFITMMSKSVRMMLNKWEEHIAHNSRLELFQHVSLMTLHSIMKCAFSHQ 199
Query: 149 RKTQDESGFD-YAMAVMKMCDIIHQRHYKFWMRSEIVFKLTSFFKQQTKLLGIIHGLTNK 207
Q +S D Y AV + I +QR F +++VFK +S + +K +H T K
Sbjct: 200 GSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFTEK 259
Query: 208 VIKNKKETYLENKAK 222
VI+++KE+ L++K K
Sbjct: 260 VIQDRKES-LKDKLK 273
>AY513608-1|AAR90939.1| 494|Homo sapiens cytochrome P450 2A13
variant 5 protein.
Length = 494
Score = 89.0 bits (211), Expect = 3e-17
Identities = 54/195 (27%), Positives = 95/195 (48%), Gaps = 4/195 (2%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
+FL M E +N + + + F G +T + + LL H +V+A+V++
Sbjct: 270 SFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHE 329
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ ++ G + +P F D +M Y E VI E R +P+ +A ++N+D +++ +P
Sbjct: 330 EIDRVIGKNRQPK-FEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKF--RDFFLP 386
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAX 452
GT V + R P+++ +P FNP +FL + Q + +++PFS G R C G A
Sbjct: 387 KGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSIGKRYCFGEGLAR 446
Query: 453 XXXXXXXXXXXRNFR 467
+NFR
Sbjct: 447 MELFLFFTTIMQNFR 461
>AY513606-1|AAR90937.1| 494|Homo sapiens cytochrome P450 2A13
variant 3 protein.
Length = 494
Score = 89.0 bits (211), Expect = 3e-17
Identities = 54/195 (27%), Positives = 95/195 (48%), Gaps = 4/195 (2%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
+FL M E +N + + + F G +T + + LL H +V+A+V++
Sbjct: 270 SFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHE 329
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ ++ G + +P F D +M Y E VI E R +P+ +A ++N+D +++ +P
Sbjct: 330 EIDRVIGKNRQPK-FEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKF--RDFFLP 386
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAX 452
GT V + R P+++ +P FNP +FL + Q + +++PFS G R C G A
Sbjct: 387 KGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSIGKRYCFGEGLAR 446
Query: 453 XXXXXXXXXXXRNFR 467
+NFR
Sbjct: 447 MELFLFFTTIMQNFR 461
>AY513605-1|AAR90936.1| 494|Homo sapiens cytochrome P450 2A13
variant 2 protein.
Length = 494
Score = 89.0 bits (211), Expect = 3e-17
Identities = 54/195 (27%), Positives = 95/195 (48%), Gaps = 4/195 (2%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
+FL M E +N + + + F G +T + + LL H +V+A+V++
Sbjct: 270 SFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHE 329
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ ++ G + +P F D +M Y E VI E R +P+ +A ++N+D +++ +P
Sbjct: 330 EIDRVIGKNRQPK-FEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKF--RDFFLP 386
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAX 452
GT V + R P+++ +P FNP +FL + Q + +++PFS G R C G A
Sbjct: 387 KGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSIGKRYCFGEGLAR 446
Query: 453 XXXXXXXXXXXRNFR 467
+NFR
Sbjct: 447 MELFLFFTTIMQNFR 461
>AY513604-1|AAR90935.1| 494|Homo sapiens cytochrome P450 2A13
variant 1 protein.
Length = 494
Score = 89.0 bits (211), Expect = 3e-17
Identities = 54/195 (27%), Positives = 95/195 (48%), Gaps = 4/195 (2%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
+FL M E +N + + + F G +T + + LL H +V+A+V++
Sbjct: 270 SFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHE 329
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ ++ G + +P F D +M Y E VI E R +P+ +A ++N+D +++ +P
Sbjct: 330 EIDRVIGKNRQPK-FEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKF--RDFFLP 386
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAX 452
GT V + R P+++ +P FNP +FL + Q + +++PFS G R C G A
Sbjct: 387 KGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSIGKRYCFGEGLAR 446
Query: 453 XXXXXXXXXXXRNFR 467
+NFR
Sbjct: 447 MELFLFFTTIMQNFR 461
>AF209774-1|AAG35775.1| 494|Homo sapiens cytochrome P450 2A13
protein.
Length = 494
Score = 89.0 bits (211), Expect = 3e-17
Identities = 54/195 (27%), Positives = 95/195 (48%), Gaps = 4/195 (2%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
+FL M E +N + + + F G +T + + LL H +V+A+V++
Sbjct: 270 SFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHE 329
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ ++ G + +P F D +M Y E VI E R +P+ +A ++N+D +++ +P
Sbjct: 330 EIDRVIGKNRQPK-FEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKF--RDFFLP 386
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAX 452
GT V + R P+++ +P FNP +FL + Q + +++PFS G R C G A
Sbjct: 387 KGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSIGKRYCFGEGLAR 446
Query: 453 XXXXXXXXXXXRNFR 467
+NFR
Sbjct: 447 MELFLFFTTIMQNFR 461
>AC023172-1|AAF32444.1| 491|Homo sapiens CYP2B6 protein.
Length = 491
Score = 89.0 bits (211), Expect = 3e-17
Identities = 97/466 (20%), Positives = 183/466 (39%), Gaps = 48/466 (10%)
Query: 16 LVNLALGYAQTFGNVIRVWLGSKLIVFLVDADDI-EIILNSHVHIDKATEYRFFKPWL-G 73
L+ L + + +G+V V LG + +V L + I E +++ + P+ G
Sbjct: 51 LLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRG 110
Query: 74 EGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGKTFDVHDYMS 133
G++ ++G +W+ R+ F + ++ F +V E+++ E
Sbjct: 111 YGVIFANGNRWKVLRR-----FSVTTMRDF----GMGKRSVEERIQEEA----------- 150
Query: 134 GTTVDILLETAMGISRKTQDESGFDYAMAVMKMCDIIHQRHYKFWMRSEIVFKLTSFFKQ 193
L+E D + ++ +C I+ + + + + + K+ + F Q
Sbjct: 151 ----QCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHY--QDQEFLKMLNLFYQ 204
Query: 194 QTKLLGIIHGLTNKVIKNKKETYLENKAKGIIPPTLEEFTHHSGEILANNAKTLSDTVFK 253
L+ + G ++ + Y + + L+E + G + + +TL + K
Sbjct: 205 TFSLISSVFGQLFELFSGFLK-YFPGAHRQVYK-NLQEINAYIGHSVEKHRETLDPSAPK 262
Query: 254 GYRDDLDFNDENDVGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAG 313
D +L M + N ++ S + ++ F G +TT+
Sbjct: 263 DLID----------------TYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTT 306
Query: 314 SSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV 373
+ L+ + V RVY E+ Q+ G RP D +M Y E VI E R +P+
Sbjct: 307 LRYGFLLMLKYPHVAERVYREIEQVIGPH-RPPELHDRAKMPYTEAVIYEIQRFSDLLPM 365
Query: 374 IARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYY 433
+ T S + Y+IP T V + P Y++ P+ FNPD+FL N +
Sbjct: 366 GVPHIVTQHT-SFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTE 424
Query: 434 SYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKL 479
++IPFS G R C+G A +NF S + ++ L
Sbjct: 425 AFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDL 470
>AY513609-1|AAR90940.1| 494|Homo sapiens cytochrome P450 2A13
variant 6 protein.
Length = 494
Score = 87.8 bits (208), Expect = 8e-17
Identities = 53/195 (27%), Positives = 95/195 (48%), Gaps = 4/195 (2%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
+FL M E +N + + + F G +T + + LL H +++A+V++
Sbjct: 270 SFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPELEAKVHE 329
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ ++ G + +P F D +M Y E VI E R +P+ +A ++N+D +++ +P
Sbjct: 330 EIDRVIGKNRQPK-FEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKF--RDFFLP 386
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAX 452
GT V + R P+++ +P FNP +FL + Q + +++PFS G R C G A
Sbjct: 387 KGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSIGKRYCFGEGLAR 446
Query: 453 XXXXXXXXXXXRNFR 467
+NFR
Sbjct: 447 MELFLFFTTIMQNFR 461
>AK090886-1|BAC03539.1| 337|Homo sapiens protein ( Homo sapiens
cDNA FLJ33567 fis, clone BRAMY2010272, highly similar to
Homo sapiens cholesterol 24-hydroxylase mRNA. ).
Length = 337
Score = 87.8 bits (208), Expect = 8e-17
Identities = 60/207 (28%), Positives = 94/207 (45%), Gaps = 16/207 (7%)
Query: 292 DHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADT 351
D + + T GH+T+A +F + L ++ AR+ E+ ++ G S R F D
Sbjct: 136 DEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIG-SKRYLDFEDL 194
Query: 352 LEMKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYY 411
++YL +V+ ESLRLYPP R L + I T+++ R Y+
Sbjct: 195 GRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDG------------FSTYVMGRMDTYF 242
Query: 412 KDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISE 471
+DP FNPD F P + R ++Y PFS G RSC+G+++A +
Sbjct: 243 EDPLTFNPDRFGPGAPKPR--FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE-FRL 299
Query: 472 IPEKEFKLQGDIILKRAEGFQMKVEPR 498
+P + F LQ LK + + PR
Sbjct: 300 VPGQRFGLQEQATLKPLDPVLCTLRPR 326
>M61856-1|AAB59356.1| 490|Homo sapiens cytochrome protein.
Length = 490
Score = 87.0 bits (206), Expect = 1e-16
Identities = 72/262 (27%), Positives = 123/262 (46%), Gaps = 21/262 (8%)
Query: 227 PTLEEFTHHSGEILANNAKTLSDTVF---KGYRDDLDFNDENDVGEKKRLAFLD-LMIES 282
P L ++ S +A N + V K +++ LD N D F+D +I+
Sbjct: 220 PALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESLDMNSARD--------FIDCFLIKM 271
Query: 283 SQNGTNKISDHEIKEEVDTI--MF-EGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIF 339
Q N+ S+ ++ + T+ MF G +TT+ + L LL + +V A+V +E+ +
Sbjct: 272 EQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVV 331
Query: 340 GDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIPAGTTVV 398
G + P D M Y + V+ E R +P + + DV KNY+IP GTT++
Sbjct: 332 GRNRSPC-MQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKF--KNYLIPKGTTII 388
Query: 399 IG-TFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXX 457
T +LH K + +PE+F+P +FL ++ + ++PFSAG R C+G A
Sbjct: 389 TSLTSVLHND-KEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFL 447
Query: 458 XXXXXXRNFRTISEIPEKEFKL 479
+NF S++ K+ +
Sbjct: 448 FLTTILQNFNLKSQVDPKDIDI 469
>BC096258-1|AAH96258.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 18 protein.
Length = 490
Score = 87.0 bits (206), Expect = 1e-16
Identities = 72/262 (27%), Positives = 123/262 (46%), Gaps = 21/262 (8%)
Query: 227 PTLEEFTHHSGEILANNAKTLSDTVF---KGYRDDLDFNDENDVGEKKRLAFLD-LMIES 282
P L ++ S +A N + V K +++ LD N D F+D +I+
Sbjct: 220 PALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESLDMNSARD--------FIDCFLIKM 271
Query: 283 SQNGTNKISDHEIKEEVDTI--MF-EGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIF 339
Q N+ S+ ++ + T+ MF G +TT+ + L LL + +V A+V +E+ +
Sbjct: 272 EQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVV 331
Query: 340 GDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIPAGTTVV 398
G + P D M Y + V+ E R +P + + DV KNY+IP GTT++
Sbjct: 332 GRNRSPC-MQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKF--KNYLIPKGTTII 388
Query: 399 IG-TFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXX 457
T +LH K + +PE+F+P +FL ++ + ++PFSAG R C+G A
Sbjct: 389 TSLTSVLHND-KEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFL 447
Query: 458 XXXXXXRNFRTISEIPEKEFKL 479
+NF S++ K+ +
Sbjct: 448 FLTTILQNFNLKSQVDPKDIDI 469
>BC096257-1|AAH96257.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 18 protein.
Length = 490
Score = 87.0 bits (206), Expect = 1e-16
Identities = 72/262 (27%), Positives = 123/262 (46%), Gaps = 21/262 (8%)
Query: 227 PTLEEFTHHSGEILANNAKTLSDTVF---KGYRDDLDFNDENDVGEKKRLAFLD-LMIES 282
P L ++ S +A N + V K +++ LD N D F+D +I+
Sbjct: 220 PALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESLDMNSARD--------FIDCFLIKM 271
Query: 283 SQNGTNKISDHEIKEEVDTI--MF-EGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIF 339
Q N+ S+ ++ + T+ MF G +TT+ + L LL + +V A+V +E+ +
Sbjct: 272 EQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVV 331
Query: 340 GDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIPAGTTVV 398
G + P D M Y + V+ E R +P + + DV KNY+IP GTT++
Sbjct: 332 GRNRSPC-MQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKF--KNYLIPKGTTII 388
Query: 399 IG-TFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXX 457
T +LH K + +PE+F+P +FL ++ + ++PFSAG R C+G A
Sbjct: 389 TSLTSVLHND-KEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFL 447
Query: 458 XXXXXXRNFRTISEIPEKEFKL 479
+NF S++ K+ +
Sbjct: 448 FLTTILQNFNLKSQVDPKDIDI 469
>BC069666-1|AAH69666.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 18 protein.
Length = 490
Score = 87.0 bits (206), Expect = 1e-16
Identities = 72/262 (27%), Positives = 123/262 (46%), Gaps = 21/262 (8%)
Query: 227 PTLEEFTHHSGEILANNAKTLSDTVF---KGYRDDLDFNDENDVGEKKRLAFLD-LMIES 282
P L ++ S +A N + V K +++ LD N D F+D +I+
Sbjct: 220 PALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESLDMNSARD--------FIDCFLIKM 271
Query: 283 SQNGTNKISDHEIKEEVDTI--MF-EGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIF 339
Q N+ S+ ++ + T+ MF G +TT+ + L LL + +V A+V +E+ +
Sbjct: 272 EQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVV 331
Query: 340 GDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIPAGTTVV 398
G + P D M Y + V+ E R +P + + DV KNY+IP GTT++
Sbjct: 332 GRNRSPC-MQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKF--KNYLIPKGTTII 388
Query: 399 IG-TFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXX 457
T +LH K + +PE+F+P +FL ++ + ++PFSAG R C+G A
Sbjct: 389 TSLTSVLHND-KEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFL 447
Query: 458 XXXXXXRNFRTISEIPEKEFKL 479
+NF S++ K+ +
Sbjct: 448 FLTTILQNFNLKSQVDPKDIDI 469
>AL583836-1|CAH74067.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 18 protein.
Length = 490
Score = 87.0 bits (206), Expect = 1e-16
Identities = 72/262 (27%), Positives = 123/262 (46%), Gaps = 21/262 (8%)
Query: 227 PTLEEFTHHSGEILANNAKTLSDTVF---KGYRDDLDFNDENDVGEKKRLAFLD-LMIES 282
P L ++ S +A N + V K +++ LD N D F+D +I+
Sbjct: 220 PALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESLDMNSARD--------FIDCFLIKM 271
Query: 283 SQNGTNKISDHEIKEEVDTI--MF-EGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIF 339
Q N+ S+ ++ + T+ MF G +TT+ + L LL + +V A+V +E+ +
Sbjct: 272 EQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVV 331
Query: 340 GDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIPAGTTVV 398
G + P D M Y + V+ E R +P + + DV KNY+IP GTT++
Sbjct: 332 GRNRSPC-MQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKF--KNYLIPKGTTII 388
Query: 399 IG-TFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXX 457
T +LH K + +PE+F+P +FL ++ + ++PFSAG R C+G A
Sbjct: 389 TSLTSVLHND-KEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFL 447
Query: 458 XXXXXXRNFRTISEIPEKEFKL 479
+NF S++ K+ +
Sbjct: 448 FLTTILQNFNLKSQVDPKDIDI 469
>X65962-1|CAA46778.1| 356|Homo sapiens cytochrome P-450 II C
protein.
Length = 356
Score = 86.6 bits (205), Expect = 2e-16
Identities = 75/259 (28%), Positives = 118/259 (45%), Gaps = 20/259 (7%)
Query: 226 PPTLEEFTHHSGEILANNAKTLS--DTVFKGYRDDLDFNDENDVGEKKRLAFLD-LMIES 282
P ++ F ++L N A T S K ++ LD N+ D F+D +I+
Sbjct: 86 PLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRD--------FIDCFLIKM 137
Query: 283 SQNGTNKISDHEIKEEVDT---IMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIF 339
Q N+ S+ I+ V T ++ G +TT+ + L LL H +V A+V +E+ ++
Sbjct: 138 EQEKDNQKSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVV 197
Query: 340 GDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVT--ISTKNYVIPAGTTV 397
G + P D M Y + V+ E R +P L VT I +NY+IP GTT+
Sbjct: 198 GRNRSPC-MQDRGHMPYTDAVVHEVQRYIDLIPT---SLPHAVTCDIKFRNYLIPKGTTI 253
Query: 398 VIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXX 457
+ + K + +PE+F+P +FL E + ++PFSAG R CVG A
Sbjct: 254 LTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFL 313
Query: 458 XXXXXXRNFRTISEIPEKE 476
+NF S I K+
Sbjct: 314 FLTFILQNFNLKSLIDPKD 332
>AK223510-1|BAD97230.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 18 variant protein.
Length = 490
Score = 86.6 bits (205), Expect = 2e-16
Identities = 72/262 (27%), Positives = 123/262 (46%), Gaps = 21/262 (8%)
Query: 227 PTLEEFTHHSGEILANNAKTLSDTVF---KGYRDDLDFNDENDVGEKKRLAFLD-LMIES 282
P L ++ S +A N + V K +++ LD N D F+D +I+
Sbjct: 220 PALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESLDMNSARD--------FIDCFLIKM 271
Query: 283 SQNGTNKISDHEIKEEVDTI--MF-EGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIF 339
Q N+ S+ ++ + T+ MF G +TT+ + L LL + +V A+V +E+ +
Sbjct: 272 EQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVV 331
Query: 340 GDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIPAGTTVV 398
G + P D M Y + V+ E R +P + + DV KNY+IP GTT++
Sbjct: 332 GRNRSPC-MQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKF--KNYLIPKGTTII 388
Query: 399 IG-TFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXX 457
T +LH K + +PE+F+P +FL ++ + ++PFSAG R C+G A
Sbjct: 389 TSLTSVLHND-KEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFL 447
Query: 458 XXXXXXRNFRTISEIPEKEFKL 479
+NF S++ K+ +
Sbjct: 448 FLTTILQNFNLKSKVDPKDIDI 469
>AK027605-1|BAB55227.1| 564|Homo sapiens protein ( Homo sapiens
cDNA FLJ14699 fis, clone NT2RP2006571, moderately
similar to CYTOCHROME P450 2G1 (EC 1.14.14.1). ).
Length = 564
Score = 85.8 bits (203), Expect = 3e-16
Identities = 64/210 (30%), Positives = 98/210 (46%), Gaps = 8/210 (3%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
AFL M + QN + ++ + V ++F G T + + L LL + VQ V +
Sbjct: 271 AFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVRE 330
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
EL + G P+ D + Y + V+ E+ RL VP+ I R L R T + Y +P
Sbjct: 331 ELNRELGAGQAPS-LGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMR--TTRFRGYTLP 387
Query: 393 AGTTV--VIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKY 450
GT V ++G+ +LH P +K PE FNPD FL + + R + +++PFS G R C+G
Sbjct: 388 QGTEVFPLLGS-ILH-DPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGL 445
Query: 451 AXXXXXXXXXXXXRNFRTISEIPEKEFKLQ 480
A + F S P L+
Sbjct: 446 AKAELFLFFTTILQAFSLESPCPPDTLSLK 475
>BC032322-1|AAH32322.1| 509|Homo sapiens cytochrome P450, family
51, subfamily A, polypeptide 1 protein.
Length = 509
Score = 85.4 bits (202), Expect = 4e-16
Identities = 45/176 (25%), Positives = 88/176 (50%), Gaps = 2/176 (1%)
Query: 276 LDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDEL 335
L +++++ ++D E+ + ++ G T++ S+++ L + +Q + Y E
Sbjct: 288 LQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQ 347
Query: 336 YQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVIPAGT 395
+ G++ P T+ ++ L+R I E+LRL PPV ++ R T++ Y IP G
Sbjct: 348 KTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPVMIMMRMARTPQTVA--GYTIPPGH 405
Query: 396 TVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYA 451
V + + R + + FNPD +L +N + ++Y+PF AG C+G +A
Sbjct: 406 QVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFA 461
>AL135960-9|CAI19736.1| 421|Homo sapiens cytochrome P450, family 4,
subfamily A, polypeptide 22 protein.
Length = 421
Score = 85.4 bits (202), Expect = 4e-16
Identities = 45/143 (31%), Positives = 74/143 (51%), Gaps = 4/143 (2%)
Query: 353 EMKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYK 412
+M Y I E+LRLYPPVP I R+L+ VT +P G V++ + LH PK +
Sbjct: 270 QMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRS-LPKGIMVLLSIYGLHHNPKVWP 328
Query: 413 DPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEI 472
+ EVF+P F P + Q H ++++PFS G R+C+G+++A F + +
Sbjct: 329 NLEVFDPSRFAPGSAQ--HSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPD- 385
Query: 473 PEKEFKLQGDIILKRAEGFQMKV 495
P + ++LK G +++
Sbjct: 386 PTRIPIPMARLVLKSKNGIHLRL 408
Score = 72.5 bits (170), Expect = 3e-12
Identities = 43/142 (30%), Positives = 78/142 (54%), Gaps = 5/142 (3%)
Query: 6 HVQEENLTQKLVNLALGYAQTFGNVIRVWL-GSKLIVFLVDADDIEIILNSHVHIDKATE 64
H+QE Q+L + +TF + W+ G K+ V L D D +++IL +
Sbjct: 62 HIQEFQHDQELQRIQ-ERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGS- 119
Query: 65 YRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGK 124
Y+F P +G GLL+ +G W HR+M+ P FH +ILK +VG+ + +++K + +G+
Sbjct: 120 YKFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQ 179
Query: 125 --TFDVHDYMSGTTVDILLETA 144
+V ++S T+D ++++A
Sbjct: 180 DSPLEVFQHVSLMTLDTIMKSA 201
>U51692-1|AAC50951.1| 503|Homo sapiens lanosterol 14-alpha
demethylase protein.
Length = 503
Score = 85.0 bits (201), Expect = 6e-16
Identities = 44/176 (25%), Positives = 88/176 (50%), Gaps = 2/176 (1%)
Query: 276 LDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDEL 335
L +++++ ++D E+ + ++ G T++ S+++ L + +Q + Y E
Sbjct: 282 LQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQ 341
Query: 336 YQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVIPAGT 395
+ G++ P T+ ++ L+R I E+LRL PP+ ++ R T++ Y IP G
Sbjct: 342 KTVCGENLPPLTYDQLKDLNLLDRCIRETLRLRPPIMIMMRMARTPQTVA--GYTIPPGH 399
Query: 396 TVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYA 451
V + + R + + FNPD +L +N + ++Y+PF AG C+G +A
Sbjct: 400 QVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFA 455
>U23942-1|AAB39951.1| 509|Homo sapiens lanosterol 14-demethylase
cytochrome P450 protein.
Length = 509
Score = 85.0 bits (201), Expect = 6e-16
Identities = 44/176 (25%), Positives = 88/176 (50%), Gaps = 2/176 (1%)
Query: 276 LDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDEL 335
L +++++ ++D E+ + ++ G T++ S+++ L + +Q + Y E
Sbjct: 288 LQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQ 347
Query: 336 YQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVIPAGT 395
+ G++ P T+ ++ L+R I E+LRL PP+ ++ R T++ Y IP G
Sbjct: 348 KTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVA--GYTIPPGH 405
Query: 396 TVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYA 451
V + + R + + FNPD +L +N + ++Y+PF AG C+G +A
Sbjct: 406 QVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFA 461
>U22028-1|AAB40519.1| 494|Homo sapiens cytochrome P450 protein.
Length = 494
Score = 85.0 bits (201), Expect = 6e-16
Identities = 54/197 (27%), Positives = 99/197 (50%), Gaps = 8/197 (4%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
+FL M E +N + + + F G +T + + LL H +V+A+V++
Sbjct: 270 SFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHE 329
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ ++ G + +P F D +M Y E VI E R +P+ +A ++N+D +++ +P
Sbjct: 330 EIDRVIGKNRQPK-FEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKF--RDFFLP 386
Query: 393 AGTTV--VIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKY 450
GT V ++G+ + R P+++ +P+ +P +FL E Q + +++PFS G R C G
Sbjct: 387 KGTEVFPMLGSEL--RDPRFFSNPQDCSPQHFLDEKGQFKKSDAFVPFSIGKRYCFGEGL 444
Query: 451 AXXXXXXXXXXXXRNFR 467
A +NFR
Sbjct: 445 ARMELFLFFTTIMQNFR 461
>D55653-1|BAA09512.1| 509|Homo sapiens lanosterol 14-demethylase
protein.
Length = 509
Score = 85.0 bits (201), Expect = 6e-16
Identities = 44/176 (25%), Positives = 88/176 (50%), Gaps = 2/176 (1%)
Query: 276 LDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDEL 335
L +++++ ++D E+ + ++ G T++ S+++ L + +Q + Y E
Sbjct: 288 LQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQ 347
Query: 336 YQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVIPAGT 395
+ G++ P T+ ++ L+R I E+LRL PP+ ++ R T++ Y IP G
Sbjct: 348 KTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVA--GYTIPPGH 405
Query: 396 TVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYA 451
V + + R + + FNPD +L +N + ++Y+PF AG C+G +A
Sbjct: 406 QVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFA 461
>AC000120-2|AAB46356.1| 509|Homo sapiens unknown protein.
Length = 509
Score = 85.0 bits (201), Expect = 6e-16
Identities = 44/176 (25%), Positives = 88/176 (50%), Gaps = 2/176 (1%)
Query: 276 LDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDEL 335
L +++++ ++D E+ + ++ G T++ S+++ L + +Q + Y E
Sbjct: 288 LQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQ 347
Query: 336 YQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVIPAGT 395
+ G++ P T+ ++ L+R I E+LRL PP+ ++ R T++ Y IP G
Sbjct: 348 KTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVA--GYTIPPGH 405
Query: 396 TVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYA 451
V + + R + + FNPD +L +N + ++Y+PF AG C+G +A
Sbjct: 406 QVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFA 461
>U22029-1|AAB40520.1| 494|Homo sapiens cytochrome P450 protein.
Length = 494
Score = 84.6 bits (200), Expect = 7e-16
Identities = 54/204 (26%), Positives = 97/204 (47%), Gaps = 4/204 (1%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
+FL M E +N + + + G +T + + LL H +V+A+V++
Sbjct: 270 SFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHE 329
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ ++ G + +P F D +M Y+E VI E R +P+ +AR++ +D +++ +P
Sbjct: 330 EIDRVIGKNRQPK-FEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKF--RDFFLP 386
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAX 452
GT V + R +++ +P FNP +FL E Q + +++PFS R+C G A
Sbjct: 387 KGTEVFPMLGSVLRDLRFFSNPRDFNPQHFLGEKGQFKKRDAFVPFSIRKRNCFGEGLAR 446
Query: 453 XXXXXXXXXXXRNFRTISEIPEKE 476
+NFR S K+
Sbjct: 447 MELFLFFTTVMQNFRLKSSQSPKD 470
>L16876-1|AAA02630.1| 490|Homo sapiens cytochrome P-4502C18
protein.
Length = 490
Score = 84.6 bits (200), Expect = 7e-16
Identities = 71/262 (27%), Positives = 122/262 (46%), Gaps = 21/262 (8%)
Query: 227 PTLEEFTHHSGEILANNAKTLSDTVF---KGYRDDLDFNDENDVGEKKRLAFLD-LMIES 282
P L ++ S +A N + V K +++ LD N D F+D +I+
Sbjct: 220 PALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESLDMNSARD--------FIDCFLIKM 271
Query: 283 SQNGTNKISDHEIKEEVDTI--MF-EGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIF 339
Q N+ S+ ++ + T+ MF G +TT+ + L LL + +V A+V +E+ +
Sbjct: 272 EQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVV 331
Query: 340 GDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIPAGTTVV 398
G + P D M Y + V+ E R +P + + DV KNY+IP G T++
Sbjct: 332 GRNRSPC-MQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKF--KNYLIPKGMTII 388
Query: 399 IG-TFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXX 457
T +LH K + +PE+F+P +FL ++ + ++PFSAG R C+G A
Sbjct: 389 TSLTSVLHND-KEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFL 447
Query: 458 XXXXXXRNFRTISEIPEKEFKL 479
+NF S++ K+ +
Sbjct: 448 FLTTILQNFNLKSQVDPKDIDI 469
>L13286-1|AAA62379.1| 513|Homo sapiens 1,25-dihydroxyvitamin D3
24-hydroxylase protein.
Length = 513
Score = 84.6 bits (200), Expect = 7e-16
Identities = 53/203 (26%), Positives = 98/203 (48%), Gaps = 10/203 (4%)
Query: 249 DTVFKGYRDDLDFNDENDVGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHD 308
DT+FK + +D N + + + D + + N++S E+ V + +
Sbjct: 275 DTIFKSVKACID----NRLEKYSQQPSADFLCDIYHQ--NRLSKKELYAAVTELQLAAVE 328
Query: 309 TTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLY 368
TTA ++L L + VQ ++ E+ + ++ RP D M YL+ + ES+RL
Sbjct: 329 TTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQRPRE-EDLRNMPYLKACLKESMRLT 387
Query: 369 PPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQ 428
P VP R L++ + Y +P GT +++ T +L ++D F P+ +L E +
Sbjct: 388 PGVPFTTRTLDKATVLG--EYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEK-E 444
Query: 429 NRHYYSYIPFSAGPRSCVGRKYA 451
+ ++++PF G R C+GR+ A
Sbjct: 445 KINPFAHLPFGVGKRMCIGRRLA 467
>Y00498-1|CAA68550.1| 490|Homo sapiens IIC2 protein.
Length = 490
Score = 82.6 bits (195), Expect = 3e-15
Identities = 74/250 (29%), Positives = 114/250 (45%), Gaps = 22/250 (8%)
Query: 226 PPTLEEFTHHSGEILANNAKTLS--DTVFKGYRDDLDFNDENDVGEKKRLAFLD-LMIES 282
P ++ F ++L N A T S K ++ LD N+ D F+D +I+
Sbjct: 220 PLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRD--------FIDCFLIKM 271
Query: 283 SQNGTNKISDHEIKEEVDTI---MFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIF 339
Q N+ S+ I+ V T+ G +TT+ + L LL H +V A+V +E+ +
Sbjct: 272 EQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVI 331
Query: 340 GDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTK--NYVIPAGTTV 397
G P D M Y + V+ E R VP + VT TK NY+IP GTT+
Sbjct: 332 GRHRSPC-MQDRSHMPYTDAVVHEIQRYSDLVPT---GVPHAVTTDTKFRNYLIPKGTTI 387
Query: 398 V-IGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXX 456
+ + T +LH K + +P +F+P +FL +N + ++PFSAG R C G A
Sbjct: 388 MALLTSVLH-DDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELF 446
Query: 457 XXXXXXXRNF 466
+NF
Sbjct: 447 LFLTTILQNF 456
>U22027-1|AAB40518.1| 494|Homo sapiens cytochrome P450 protein.
Length = 494
Score = 82.6 bits (195), Expect = 3e-15
Identities = 53/204 (25%), Positives = 96/204 (47%), Gaps = 4/204 (1%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
+FL M E +N + + + G +T + + LL H +V+A+V++
Sbjct: 270 SFLIRMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLHYGFLLLMKHPEVEAKVHE 329
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ ++ G + +P F D +M Y+E VI E R +P+ +AR++ +D +++ +P
Sbjct: 330 EIDRVIGKNRQPK-FEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKF--RDFFLP 386
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAX 452
G V + R +++ +P FNP +FL E Q + +++PFS R+C G A
Sbjct: 387 KGIEVFPMLGSVLRDLRFFSNPRDFNPQHFLGEKGQFKKRDAFVPFSIRKRNCFGEGLAR 446
Query: 453 XXXXXXXXXXXRNFRTISEIPEKE 476
+NFR S K+
Sbjct: 447 MELFLFFTTVMQNFRLKSSQSPKD 470
>M17397-1|AAA35739.1| 490|Homo sapiens protein ( Human cytochrome
P-450 1 functional form mRNA, complete cds. ).
Length = 490
Score = 82.6 bits (195), Expect = 3e-15
Identities = 70/246 (28%), Positives = 110/246 (44%), Gaps = 14/246 (5%)
Query: 226 PPTLEEFTHHSGEILANNAKTLS--DTVFKGYRDDLDFNDENDVGEKKRLAFLDLMIESS 283
P ++ F ++L N A T S K ++ LD N+ D + FL M +
Sbjct: 220 PLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFMD----CFLIKMEQEK 275
Query: 284 QNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSD 343
N ++ + + V + G +TT+ + L LL H +V A+V +E+ + G
Sbjct: 276 DNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHR 335
Query: 344 RPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTK--NYVIPAGTTVV-IG 400
P D M Y + V+ E R VP + VT TK NY+IP GTT++ +
Sbjct: 336 SPC-MQDRSHMPYTDAVVHEIQRYSDLVPT---GVPHAVTTDTKFRNYLIPKGTTIMALL 391
Query: 401 TFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXX 460
T +LH K + +P +F+P +FL +N + ++PFSAG R C G A
Sbjct: 392 TSVLH-DDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLT 450
Query: 461 XXXRNF 466
+NF
Sbjct: 451 TILQNF 456
>BC020596-1|AAH20596.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 8 protein.
Length = 490
Score = 82.6 bits (195), Expect = 3e-15
Identities = 74/250 (29%), Positives = 114/250 (45%), Gaps = 22/250 (8%)
Query: 226 PPTLEEFTHHSGEILANNAKTLS--DTVFKGYRDDLDFNDENDVGEKKRLAFLD-LMIES 282
P ++ F ++L N A T S K ++ LD N+ D F+D +I+
Sbjct: 220 PLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRD--------FIDCFLIKM 271
Query: 283 SQNGTNKISDHEIKEEVDTI---MFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIF 339
Q N+ S+ I+ V T+ G +TT+ + L LL H +V A+V +E+ +
Sbjct: 272 EQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVI 331
Query: 340 GDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTK--NYVIPAGTTV 397
G P D M Y + V+ E R VP + VT TK NY+IP GTT+
Sbjct: 332 GRHRSPC-MQDRSHMPYTDAVVHEIQRYSDLVPT---GVPHAVTTDTKFRNYLIPKGTTI 387
Query: 398 V-IGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXX 456
+ + T +LH K + +P +F+P +FL +N + ++PFSAG R C G A
Sbjct: 388 MALLTSVLH-DDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELF 446
Query: 457 XXXXXXXRNF 466
+NF
Sbjct: 447 LFLTTILQNF 456
>AY514490-1|AAR89907.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 8 protein.
Length = 490
Score = 82.6 bits (195), Expect = 3e-15
Identities = 74/250 (29%), Positives = 114/250 (45%), Gaps = 22/250 (8%)
Query: 226 PPTLEEFTHHSGEILANNAKTLS--DTVFKGYRDDLDFNDENDVGEKKRLAFLD-LMIES 282
P ++ F ++L N A T S K ++ LD N+ D F+D +I+
Sbjct: 220 PLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRD--------FIDCFLIKM 271
Query: 283 SQNGTNKISDHEIKEEVDTI---MFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIF 339
Q N+ S+ I+ V T+ G +TT+ + L LL H +V A+V +E+ +
Sbjct: 272 EQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVI 331
Query: 340 GDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTK--NYVIPAGTTV 397
G P D M Y + V+ E R VP + VT TK NY+IP GTT+
Sbjct: 332 GRHRSPC-MQDRSHMPYTDAVVHEIQRYSDLVPT---GVPHAVTTDTKFRNYLIPKGTTI 387
Query: 398 V-IGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXX 456
+ + T +LH K + +P +F+P +FL +N + ++PFSAG R C G A
Sbjct: 388 MALLTSVLH-DDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELF 446
Query: 457 XXXXXXXRNF 466
+NF
Sbjct: 447 LFLTTILQNF 456
>AL359672-5|CAH71307.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 8 protein.
Length = 490
Score = 82.6 bits (195), Expect = 3e-15
Identities = 74/250 (29%), Positives = 114/250 (45%), Gaps = 22/250 (8%)
Query: 226 PPTLEEFTHHSGEILANNAKTLS--DTVFKGYRDDLDFNDENDVGEKKRLAFLD-LMIES 282
P ++ F ++L N A T S K ++ LD N+ D F+D +I+
Sbjct: 220 PLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRD--------FIDCFLIKM 271
Query: 283 SQNGTNKISDHEIKEEVDTI---MFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIF 339
Q N+ S+ I+ V T+ G +TT+ + L LL H +V A+V +E+ +
Sbjct: 272 EQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVI 331
Query: 340 GDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTK--NYVIPAGTTV 397
G P D M Y + V+ E R VP + VT TK NY+IP GTT+
Sbjct: 332 GRHRSPC-MQDRSHMPYTDAVVHEIQRYSDLVPT---GVPHAVTTDTKFRNYLIPKGTTI 387
Query: 398 V-IGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXX 456
+ + T +LH K + +P +F+P +FL +N + ++PFSAG R C G A
Sbjct: 388 MALLTSVLH-DDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELF 446
Query: 457 XXXXXXXRNF 466
+NF
Sbjct: 447 LFLTTILQNF 456
>S67623-1|AAB29308.1| 257|Homo sapiens 25-hydroxyvitamin D
24-hydroxylase cytochrome P450 subunit protein.
Length = 257
Score = 82.2 bits (194), Expect = 4e-15
Identities = 52/203 (25%), Positives = 97/203 (47%), Gaps = 10/203 (4%)
Query: 249 DTVFKGYRDDLDFNDENDVGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHD 308
DT+FK + +D N + + + D + + N++S E+ V + +
Sbjct: 19 DTIFKSVKACID----NRLEKYSQQPSADFLCDIYHQ--NRLSKKELYAAVTELQLAAVE 72
Query: 309 TTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLY 368
TTA ++L L + VQ ++ E+ + ++ P D M YL+ + ES+RL
Sbjct: 73 TTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRA-EDLRNMPYLKACLKESMRLT 131
Query: 369 PPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQ 428
P VP R L++ + Y +P GT +++ T +L ++D F P+ +L E +
Sbjct: 132 PSVPFTTRTLDKATVLG--EYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEK-E 188
Query: 429 NRHYYSYIPFSAGPRSCVGRKYA 451
+ ++++PF G R C+GR+ A
Sbjct: 189 KINPFAHLPFGVGKRMCIGRRLA 211
>AY858838-1|AAW50795.1| 372|Homo sapiens vitamin D 24-hydroxylase
splice variant protein.
Length = 372
Score = 82.2 bits (194), Expect = 4e-15
Identities = 52/203 (25%), Positives = 97/203 (47%), Gaps = 10/203 (4%)
Query: 249 DTVFKGYRDDLDFNDENDVGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHD 308
DT+FK + +D N + + + D + + N++S E+ V + +
Sbjct: 134 DTIFKSVKACID----NRLEKYSQQPSADFLCDIYHQ--NRLSKKELYAAVTELQLAAVE 187
Query: 309 TTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLY 368
TTA ++L L + VQ ++ E+ + ++ P D M YL+ + ES+RL
Sbjct: 188 TTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRA-EDLRNMPYLKACLKESMRLT 246
Query: 369 PPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQ 428
P VP R L++ + Y +P GT +++ T +L ++D F P+ +L E +
Sbjct: 247 PSVPFTTRTLDKATVLG--EYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEK-E 303
Query: 429 NRHYYSYIPFSAGPRSCVGRKYA 451
+ ++++PF G R C+GR+ A
Sbjct: 304 KINPFAHLPFGVGKRMCIGRRLA 326
>AL138805-3|CAB91829.1| 514|Homo sapiens cytochrome P450, family
24, subfamily A, polypeptide 1 protein.
Length = 514
Score = 82.2 bits (194), Expect = 4e-15
Identities = 52/203 (25%), Positives = 97/203 (47%), Gaps = 10/203 (4%)
Query: 249 DTVFKGYRDDLDFNDENDVGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHD 308
DT+FK + +D N + + + D + + N++S E+ V + +
Sbjct: 276 DTIFKSVKACID----NRLEKYSQQPSADFLCDIYHQ--NRLSKKELYAAVTELQLAAVE 329
Query: 309 TTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLY 368
TTA ++L L + VQ ++ E+ + ++ P D M YL+ + ES+RL
Sbjct: 330 TTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRA-EDLRNMPYLKACLKESMRLT 388
Query: 369 PPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQ 428
P VP R L++ + Y +P GT +++ T +L ++D F P+ +L E +
Sbjct: 389 PSVPFTTRTLDKATVLG--EYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEK-E 445
Query: 429 NRHYYSYIPFSAGPRSCVGRKYA 451
+ ++++PF G R C+GR+ A
Sbjct: 446 KINPFAHLPFGVGKRMCIGRRLA 468
>AL138805-1|CAM27342.1| 372|Homo sapiens cytochrome P450, family
24, subfamily A, polypeptide 1 protein.
Length = 372
Score = 82.2 bits (194), Expect = 4e-15
Identities = 52/203 (25%), Positives = 97/203 (47%), Gaps = 10/203 (4%)
Query: 249 DTVFKGYRDDLDFNDENDVGEKKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHD 308
DT+FK + +D N + + + D + + N++S E+ V + +
Sbjct: 134 DTIFKSVKACID----NRLEKYSQQPSADFLCDIYHQ--NRLSKKELYAAVTELQLAAVE 187
Query: 309 TTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLY 368
TTA ++L L + VQ ++ E+ + ++ P D M YL+ + ES+RL
Sbjct: 188 TTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRA-EDLRNMPYLKACLKESMRLT 246
Query: 369 PPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQ 428
P VP R L++ + Y +P GT +++ T +L ++D F P+ +L E +
Sbjct: 247 PSVPFTTRTLDKATVLG--EYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEK-E 303
Query: 429 NRHYYSYIPFSAGPRSCVGRKYA 451
+ ++++PF G R C+GR+ A
Sbjct: 304 KINPFAHLPFGVGKRMCIGRRLA 326
>BX538127-1|CAD98029.1| 310|Homo sapiens hypothetical protein
protein.
Length = 310
Score = 81.8 bits (193), Expect = 5e-15
Identities = 65/233 (27%), Positives = 113/233 (48%), Gaps = 13/233 (5%)
Query: 255 YRDDLDFNDENDVGEKKRLAFLDLMIESS---QNGTNKISDHEIKEEVDTI--MF-EGHD 308
+ D D+ D+ + ++ +L I SS Q N+ S+ ++ + T+ MF G +
Sbjct: 62 FHDRFDYKDQRFLNLMEKFNE-NLRILSSPWIQEKHNQQSEFTVESLIATVTDMFGAGTE 120
Query: 309 TTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLY 368
TT+ + L LL + +V A+V +E+ + G + P D M Y + V+ E R
Sbjct: 121 TTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPC-MQDRSHMPYTDAVVHEIQRYI 179
Query: 369 PPVPV-IARKLNRDVTISTKNYVIPAGTTVVIG-TFMLHRQPKYYKDPEVFNPDNFLPEN 426
+P + + DV KNY+IP GTT++ T +LH K + +PE+F+P +FL ++
Sbjct: 180 DLLPTNLPHAVTCDVKF--KNYLIPKGTTIITSLTSVLHND-KEFPNPEMFDPGHFLDKS 236
Query: 427 TQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKL 479
+ ++PFSAG R C+G A +NF S++ K+ +
Sbjct: 237 GNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDI 289
>BC096260-1|AAH96260.1| 431|Homo sapiens CYP2C18 protein protein.
Length = 431
Score = 81.8 bits (193), Expect = 5e-15
Identities = 65/233 (27%), Positives = 113/233 (48%), Gaps = 13/233 (5%)
Query: 255 YRDDLDFNDENDVGEKKRLAFLDLMIESS---QNGTNKISDHEIKEEVDTI--MF-EGHD 308
+ D D+ D+ + ++ +L I SS Q N+ S+ ++ + T+ MF G +
Sbjct: 183 FHDRFDYKDQRFLNLMEKFNE-NLRILSSPWIQEKHNQQSEFTVESLIATVTDMFGAGTE 241
Query: 309 TTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLY 368
TT+ + L LL + +V A+V +E+ + G + P D M Y + V+ E R
Sbjct: 242 TTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPC-MQDRSHMPYTDAVVHEIQRYI 300
Query: 369 PPVPV-IARKLNRDVTISTKNYVIPAGTTVVIG-TFMLHRQPKYYKDPEVFNPDNFLPEN 426
+P + + DV KNY+IP GTT++ T +LH K + +PE+F+P +FL ++
Sbjct: 301 DLLPTNLPHAVTCDVKF--KNYLIPKGTTIITSLTSVLHND-KEFPNPEMFDPGHFLDKS 357
Query: 427 TQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXXXRNFRTISEIPEKEFKL 479
+ ++PFSAG R C+G A +NF S++ K+ +
Sbjct: 358 GNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDI 410
>BC022851-1|AAH22851.1| 215|Homo sapiens CYP4A11 protein protein.
Length = 215
Score = 81.8 bits (193), Expect = 5e-15
Identities = 46/142 (32%), Positives = 79/142 (55%), Gaps = 5/142 (3%)
Query: 6 HVQEENLTQKLVNLALGYAQTFGNVIRVWL-GSKLIVFLVDADDIEIILNSHVHIDKATE 64
H+QE Q+L + + +TF + WL G K+ V L D D +++IL +
Sbjct: 62 HIQELQQDQELQRIQK-WVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGS- 119
Query: 65 YRFFKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGK 124
YRF PW+G GLL+ +G W HR+M+ P FH +ILK +VG+ + +++K + +G+
Sbjct: 120 YRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQ 179
Query: 125 --TFDVHDYMSGTTVDILLETA 144
+V ++S T+D +++ A
Sbjct: 180 DSPLEVFQHVSLMTLDTIMKCA 201
>M21942-1|AAA52161.1| 462|Homo sapiens CYP2C protein.
Length = 462
Score = 81.4 bits (192), Expect = 7e-15
Identities = 62/199 (31%), Positives = 95/199 (47%), Gaps = 12/199 (6%)
Query: 275 FLD-LMIESSQNGTNKISDHEIKEEVDTI---MFEGHDTTAAGSSFVLCLLGIHQDVQAR 330
F+D +I+ Q N+ S+ I+ V T+ G +TT+ + L LL H +V A+
Sbjct: 235 FIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAK 294
Query: 331 VYDELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTK--N 388
V +E+ + G P D M Y + V+ E R VP + VT TK N
Sbjct: 295 VQEEIDHVIGRHRSPC-MQDRSHMPYTDAVVHEIQRYSDLVPT---GVPHAVTTDTKFRN 350
Query: 389 YVIPAGTTVV-IGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVG 447
Y+IP GTT++ + T +LH K + +P +F+P +FL +N + ++PFSAG R C G
Sbjct: 351 YLIPKGTTIMALLTSVLH-DDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAG 409
Query: 448 RKYAXXXXXXXXXXXXRNF 466
A +NF
Sbjct: 410 EGLARMELFLFLTTILQNF 428
>L39102-1|AAL31348.1| 217|Homo sapiens S-mephenytoin 4-hydroxylase
protein.
Length = 217
Score = 81.4 bits (192), Expect = 7e-15
Identities = 59/194 (30%), Positives = 91/194 (46%), Gaps = 9/194 (4%)
Query: 288 NKISDHEIKEEVDT---IMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDR 344
N+ S+ I+ V T ++ G +TT+ + L LL H +V A+V +E+ ++ G +
Sbjct: 4 NQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRS 63
Query: 345 PATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTK--NYVIPAGTTVVIGTF 402
P D M Y + V+ E R +P L VT K NY+IP GTT++
Sbjct: 64 PC-MQDRGHMPYTDAVVHEVQRYIDLIPT---SLPHAVTCDVKFRNYLIPKGTTILTSLT 119
Query: 403 MLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXXXXXXXX 462
+ K + +PE+F+P +FL E + ++PFSAG R CVG A
Sbjct: 120 SVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFI 179
Query: 463 XRNFRTISEIPEKE 476
+NF S I K+
Sbjct: 180 LQNFNLKSLIDPKD 193
>M21941-1|AAA52160.1| 480|Homo sapiens CYP2C protein.
Length = 480
Score = 81.0 bits (191), Expect = 9e-15
Identities = 74/250 (29%), Positives = 113/250 (45%), Gaps = 22/250 (8%)
Query: 226 PPTLEEFTHHSGEILANNAKTLS--DTVFKGYRDDLDFNDENDVGEKKRLAFLD-LMIES 282
P ++ F ++L N A T S K ++ LD N+ D F+D +I+
Sbjct: 210 PLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRD--------FIDCFLIKM 261
Query: 283 SQNGTNKISDHEIKEEVDTI---MFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIF 339
Q N+ S+ I+ V T+ G +TT+ + L LL H +V A+V +E+ +
Sbjct: 262 EQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVI 321
Query: 340 GDSDRPATFADTLEMKYLERVILESLRLYPPVPVIARKLNRDVTISTK--NYVIPAGTTV 397
G P D M Y + V+ E R VP + VT TK NY+IP GTT+
Sbjct: 322 GRHRSPC-MQDRSHMPYTDAVVHEIQRYSDLVPT---GVPHAVTTDTKFRNYLIPKGTTI 377
Query: 398 V-IGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYAXXXXX 456
+ + T +LH K + +P +F+P FL +N + ++PFSAG R C G A
Sbjct: 378 MALLTSVLH-DDKEFPNPNIFDPGLFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELF 436
Query: 457 XXXXXXXRNF 466
+NF
Sbjct: 437 LFLTTILQNF 446
>AK131190-1|BAD18388.1| 372|Homo sapiens .-.-). protein.
Length = 372
Score = 81.0 bits (191), Expect = 9e-15
Identities = 50/159 (31%), Positives = 82/159 (51%), Gaps = 4/159 (2%)
Query: 294 EIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLE 353
EI V ++ G DTT+ S+ + LL H +VQ VY E+ + G+ P T AD +
Sbjct: 169 EIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVP-TAADVPK 227
Query: 354 MKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKD 413
+ + ++ E+LRL+P +P R D+ I Y+IP GT + + + Q + +
Sbjct: 228 VPLVRALLKETLRLFPVLPGNGRVTQEDLVIG--GYLIPKGTQLALCHYATSYQDENFPR 285
Query: 414 PEVFNPDNFLPENTQNR-HYYSYIPFSAGPRSCVGRKYA 451
+ F P+ +L + +R + IPF G RSC+GR+ A
Sbjct: 286 AKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIA 324
>BC109205-1|AAI09206.1| 512|Homo sapiens cytochrome P450, family
26, subfamily B, polypeptide 1 protein.
Length = 512
Score = 80.2 bits (189), Expect = 2e-14
Identities = 57/189 (30%), Positives = 96/189 (50%), Gaps = 9/189 (4%)
Query: 270 KKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQA 329
K L LDL+IESS+ +++ E+K+ ++F + TTA+ S+ ++ L H V
Sbjct: 261 KDYLDALDLLIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLE 320
Query: 330 RVYDEL--YQIFGDSDRPATFA---DTLE-MKYLERVILESLRLYPPVPVIARKLNRDVT 383
++ DEL + I P DTL ++YL+ VI E +RL+ P+ R + + T
Sbjct: 321 KLRDELRAHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQ--T 378
Query: 384 ISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRH-YYSYIPFSAGP 442
+ IP G +V+ H +KD VF+PD F ++++ + Y+PF G
Sbjct: 379 FELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGV 438
Query: 443 RSCVGRKYA 451
R+C+G+ A
Sbjct: 439 RTCLGKHLA 447
>BC069443-1|AAH69443.1| 512|Homo sapiens cytochrome P450, family
26, subfamily B, polypeptide 1 protein.
Length = 512
Score = 80.2 bits (189), Expect = 2e-14
Identities = 57/189 (30%), Positives = 96/189 (50%), Gaps = 9/189 (4%)
Query: 270 KKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQA 329
K L LDL+IESS+ +++ E+K+ ++F + TTA+ S+ ++ L H V
Sbjct: 261 KDYLDALDLLIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLE 320
Query: 330 RVYDEL--YQIFGDSDRPATFA---DTLE-MKYLERVILESLRLYPPVPVIARKLNRDVT 383
++ DEL + I P DTL ++YL+ VI E +RL+ P+ R + + T
Sbjct: 321 KLRDELRAHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQ--T 378
Query: 384 ISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRH-YYSYIPFSAGP 442
+ IP G +V+ H +KD VF+PD F ++++ + Y+PF G
Sbjct: 379 FELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGV 438
Query: 443 RSCVGRKYA 451
R+C+G+ A
Sbjct: 439 RTCLGKHLA 447
>BC039307-1|AAH39307.1| 372|Homo sapiens FLJ16008 protein protein.
Length = 372
Score = 80.2 bits (189), Expect = 2e-14
Identities = 49/159 (30%), Positives = 82/159 (51%), Gaps = 4/159 (2%)
Query: 294 EIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLE 353
EI V ++ G DTT+ S+ + +L H +VQ VY E+ + G+ P T AD +
Sbjct: 169 EIYANVTEMLLAGVDTTSFTLSWTVYILARHPEVQQTVYREIVKNLGERHVP-TAADVPK 227
Query: 354 MKYLERVILESLRLYPPVPVIARKLNRDVTISTKNYVIPAGTTVVIGTFMLHRQPKYYKD 413
+ + ++ E+LRL+P +P R D+ I Y+IP GT + + + Q + +
Sbjct: 228 VPLVRALLKETLRLFPVLPGNGRVTQEDLVIG--GYLIPKGTQLALCHYATSYQDENFPR 285
Query: 414 PEVFNPDNFLPENTQNR-HYYSYIPFSAGPRSCVGRKYA 451
+ F P+ +L + +R + IPF G RSC+GR+ A
Sbjct: 286 AKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIA 324
>AF252297-1|AAF76003.1| 512|Homo sapiens cytochrome P450 retinoid
metabolizing protein P450RAI-2 protein.
Length = 512
Score = 80.2 bits (189), Expect = 2e-14
Identities = 57/189 (30%), Positives = 96/189 (50%), Gaps = 9/189 (4%)
Query: 270 KKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQA 329
K L LDL+IESS+ +++ E+K+ ++F + TTA+ S+ ++ L H V
Sbjct: 261 KDYLDALDLLIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLE 320
Query: 330 RVYDEL--YQIFGDSDRPATFA---DTLE-MKYLERVILESLRLYPPVPVIARKLNRDVT 383
++ DEL + I P DTL ++YL+ VI E +RL+ P+ R + + T
Sbjct: 321 KLRDELRAHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQ--T 378
Query: 384 ISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRH-YYSYIPFSAGP 442
+ IP G +V+ H +KD VF+PD F ++++ + Y+PF G
Sbjct: 379 FELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGV 438
Query: 443 RSCVGRKYA 451
R+C+G+ A
Sbjct: 439 RTCLGKHLA 447
>AC007002-1|AAY14690.1| 512|Homo sapiens unknown protein.
Length = 512
Score = 80.2 bits (189), Expect = 2e-14
Identities = 57/189 (30%), Positives = 96/189 (50%), Gaps = 9/189 (4%)
Query: 270 KKRLAFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQA 329
K L LDL+IESS+ +++ E+K+ ++F + TTA+ S+ ++ L H V
Sbjct: 261 KDYLDALDLLIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLE 320
Query: 330 RVYDEL--YQIFGDSDRPATFA---DTLE-MKYLERVILESLRLYPPVPVIARKLNRDVT 383
++ DEL + I P DTL ++YL+ VI E +RL+ P+ R + + T
Sbjct: 321 KLRDELRAHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQ--T 378
Query: 384 ISTKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRH-YYSYIPFSAGP 442
+ IP G +V+ H +KD VF+PD F ++++ + Y+PF G
Sbjct: 379 FELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGV 438
Query: 443 RSCVGRKYA 451
R+C+G+ A
Sbjct: 439 RTCLGKHLA 447
>AF221943-1|AAF86378.1| 175|Homo sapiens leukotriene B4 omega
hydroxylase protein.
Length = 175
Score = 79.8 bits (188), Expect = 2e-14
Identities = 38/105 (36%), Positives = 61/105 (58%), Gaps = 3/105 (2%)
Query: 11 NLTQKLVNLALGYAQTFGNVIRVWLGS-KLIVFLVDADDIEIILNSHVHIDKATE--YRF 67
N T++ + + T+ +VW+G ++ L D I ++N+ I + Y F
Sbjct: 68 NPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSF 127
Query: 68 FKPWLGEGLLISSGPKWRSHRKMIAPTFHINILKSFVGIFNQNSN 112
+PWLG+GLL+S+G KW HR+M+ P FH NILK ++ IFN++ N
Sbjct: 128 LEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVN 172
>M33388-1|AAA53500.1| 497|Homo sapiens cytochrome P450 IID6
protein.
Length = 497
Score = 79.4 bits (187), Expect = 3e-14
Identities = 52/179 (29%), Positives = 87/179 (48%), Gaps = 4/179 (2%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
AFL M ++ N + +D ++ V + G TT+ ++ L L+ +H DVQ RV
Sbjct: 274 AFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQ 333
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ + G RP D M Y VI E R VP+ + +RD+ + + + IP
Sbjct: 334 EIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIP 390
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYA 451
GTT++ + + ++ P F+P++FL +++PFSAG R+C+G A
Sbjct: 391 KGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLA 449
>M33189-1|AAA35737.1| 500|Homo sapiens protein ( Human debrisoquine
4-hydroxylase mutant allele (CYP2D6-MA1) gene, complete
cds. ).
Length = 500
Score = 79.4 bits (187), Expect = 3e-14
Identities = 52/179 (29%), Positives = 87/179 (48%), Gaps = 4/179 (2%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
AFL M ++ N + +D ++ V + G TT+ ++ L L+ +H DVQ RV
Sbjct: 277 AFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQ 336
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ + G RP D M Y VI E R VP+ + +RD+ + + + IP
Sbjct: 337 EIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIP 393
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYA 451
GTT++ + + ++ P F+P++FL +++PFSAG R+C+G A
Sbjct: 394 KGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLA 452
>M24499-1|AAA36403.1| 373|Homo sapiens cytochrome P450db1 protein.
Length = 373
Score = 79.4 bits (187), Expect = 3e-14
Identities = 52/179 (29%), Positives = 87/179 (48%), Gaps = 4/179 (2%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
AFL M ++ N + +D ++ V + G TT+ ++ L L+ +H DVQ RV
Sbjct: 150 AFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQ 209
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ + G RP D M Y VI E R VP+ + +RD+ + + + IP
Sbjct: 210 EIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIP 266
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYA 451
GTT++ + + ++ P F+P++FL +++PFSAG R+C+G A
Sbjct: 267 KGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLA 325
>DQ282154-1|ABB77902.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 79.4 bits (187), Expect = 3e-14
Identities = 52/179 (29%), Positives = 87/179 (48%), Gaps = 4/179 (2%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
AFL M ++ N + +D ++ V + G TT+ ++ L L+ +H DVQ RV
Sbjct: 274 AFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQ 333
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ + G RP D M Y VI E R VP+ + +RD+ + + + IP
Sbjct: 334 EIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIP 390
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYA 451
GTT++ + + ++ P F+P++FL +++PFSAG R+C+G A
Sbjct: 391 KGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLA 449
>DQ282152-1|ABB77900.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 79.4 bits (187), Expect = 3e-14
Identities = 52/179 (29%), Positives = 87/179 (48%), Gaps = 4/179 (2%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
AFL M ++ N + +D ++ V + G TT+ ++ L L+ +H DVQ RV
Sbjct: 274 AFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQ 333
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ + G RP D M Y VI E R VP+ + +RD+ + + + IP
Sbjct: 334 EIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIP 390
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYA 451
GTT++ + + ++ P F+P++FL +++PFSAG R+C+G A
Sbjct: 391 KGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLA 449
>DQ282146-1|ABB77897.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 79.4 bits (187), Expect = 3e-14
Identities = 52/179 (29%), Positives = 87/179 (48%), Gaps = 4/179 (2%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
AFL M ++ N + +D ++ V + G TT+ ++ L L+ +H DVQ RV
Sbjct: 274 AFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQ 333
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ + G RP D M Y VI E R VP+ + +RD+ + + + IP
Sbjct: 334 EIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIP 390
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYA 451
GTT++ + + ++ P F+P++FL +++PFSAG R+C+G A
Sbjct: 391 KGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLA 449
>DQ282145-1|ABB77896.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 79.4 bits (187), Expect = 3e-14
Identities = 52/179 (29%), Positives = 87/179 (48%), Gaps = 4/179 (2%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
AFL M ++ N + +D ++ V + G TT+ ++ L L+ +H DVQ RV
Sbjct: 274 AFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQ 333
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ + G RP D M Y VI E R VP+ + +RD+ + + + IP
Sbjct: 334 EIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIP 390
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYA 451
GTT++ + + ++ P F+P++FL +++PFSAG R+C+G A
Sbjct: 391 KGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLA 449
>DQ282144-1|ABB77895.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 79.4 bits (187), Expect = 3e-14
Identities = 52/179 (29%), Positives = 87/179 (48%), Gaps = 4/179 (2%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
AFL M ++ N + +D ++ V + G TT+ ++ L L+ +H DVQ RV
Sbjct: 274 AFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQ 333
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ + G RP D M Y VI E R VP+ + +RD+ + + + IP
Sbjct: 334 EIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIP 390
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYA 451
GTT++ + + ++ P F+P++FL +++PFSAG R+C+G A
Sbjct: 391 KGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLA 449
>DQ211354-2|ABB01372.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 79.4 bits (187), Expect = 3e-14
Identities = 52/179 (29%), Positives = 87/179 (48%), Gaps = 4/179 (2%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
AFL M ++ N + +D ++ V + G TT+ ++ L L+ +H DVQ RV
Sbjct: 274 AFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQ 333
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ + G RP D M Y VI E R VP+ + +RD+ + + + IP
Sbjct: 334 EIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIP 390
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYA 451
GTT++ + + ++ P F+P++FL +++PFSAG R+C+G A
Sbjct: 391 KGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLA 449
>DQ211353-2|ABB01371.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 79.4 bits (187), Expect = 3e-14
Identities = 52/179 (29%), Positives = 87/179 (48%), Gaps = 4/179 (2%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
AFL M ++ N + +D ++ V + G TT+ ++ L L+ +H DVQ RV
Sbjct: 274 AFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQ 333
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ + G RP D M Y VI E R VP+ + +RD+ + + + IP
Sbjct: 334 EIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIP 390
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYA 451
GTT++ + + ++ P F+P++FL +++PFSAG R+C+G A
Sbjct: 391 KGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLA 449
>DQ211353-1|ABB01370.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 79.4 bits (187), Expect = 3e-14
Identities = 52/179 (29%), Positives = 87/179 (48%), Gaps = 4/179 (2%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
AFL M ++ N + +D ++ V + G TT+ ++ L L+ +H DVQ RV
Sbjct: 274 AFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQ 333
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ + G RP D M Y VI E R VP+ + +RD+ + + + IP
Sbjct: 334 EIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIP 390
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYA 451
GTT++ + + ++ P F+P++FL +++PFSAG R+C+G A
Sbjct: 391 KGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLA 449
>BC075024-1|AAH75024.1| 497|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 497
Score = 79.4 bits (187), Expect = 3e-14
Identities = 52/179 (29%), Positives = 87/179 (48%), Gaps = 4/179 (2%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
AFL M ++ N + +D ++ V + G TT+ ++ L L+ +H DVQ RV
Sbjct: 274 AFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQ 333
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ + G RP D M Y VI E R VP+ + +RD+ + + + IP
Sbjct: 334 EIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIP 390
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYA 451
GTT++ + + ++ P F+P++FL +++PFSAG R+C+G A
Sbjct: 391 KGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLA 449
>BC075023-1|AAH75023.1| 497|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 497
Score = 79.4 bits (187), Expect = 3e-14
Identities = 52/179 (29%), Positives = 87/179 (48%), Gaps = 4/179 (2%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
AFL M ++ N + +D ++ V + G TT+ ++ L L+ +H DVQ RV
Sbjct: 274 AFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQ 333
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ + G RP D M Y VI E R VP+ + +RD+ + + + IP
Sbjct: 334 EIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIP 390
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYA 451
GTT++ + + ++ P F+P++FL +++PFSAG R+C+G A
Sbjct: 391 KGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLA 449
>AY545216-1|AAS55001.1| 497|Homo sapiens cytochrome P4502D6
protein.
Length = 497
Score = 79.4 bits (187), Expect = 3e-14
Identities = 52/179 (29%), Positives = 87/179 (48%), Gaps = 4/179 (2%)
Query: 274 AFLDLMIESSQNGTNKISDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIHQDVQARVYD 333
AFL M ++ N + +D ++ V + G TT+ ++ L L+ +H DVQ RV
Sbjct: 274 AFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQ 333
Query: 334 ELYQIFGDSDRPATFADTLEMKYLERVILESLRLYPPVPV-IARKLNRDVTISTKNYVIP 392
E+ + G RP D M Y VI E R VP+ + +RD+ + + + IP
Sbjct: 334 EIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIP 390
Query: 393 AGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCVGRKYA 451
GTT++ + + ++ P F+P++FL +++PFSAG R+C+G A
Sbjct: 391 KGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLA 449
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.320 0.137 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 71,126,401
Number of Sequences: 224733
Number of extensions: 2907580
Number of successful extensions: 7061
Number of sequences better than 10.0: 453
Number of HSP's better than 10.0 without gapping: 342
Number of HSP's successfully gapped in prelim test: 111
Number of HSP's that attempted gapping in prelim test: 5711
Number of HSP's gapped (non-prelim): 737
length of query: 507
length of database: 73,234,838
effective HSP length: 93
effective length of query: 414
effective length of database: 52,334,669
effective search space: 21666552966
effective search space used: 21666552966
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.8 bits)
S2: 67 (31.1 bits)
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