Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA000994-TA|BGIBMGA000994-PA|IPR010097|Malate
dehydrogenase, NAD-dependent, eukaryotes and gamma proteobacteria,
IPR001236|Lactate/malate dehydrogenase
(329 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q9SN86 Cluster: Malate dehydrogenase, chloroplast precu... 193 5e-48
UniRef50_P40926 Cluster: Malate dehydrogenase, mitochondrial pre... 186 5e-46
UniRef50_Q9VU28 Cluster: Malate dehydrogenase; n=3; Sophophora|R... 186 7e-46
UniRef50_P08249 Cluster: Malate dehydrogenase, mitochondrial pre... 186 7e-46
UniRef50_Q42972 Cluster: Malate dehydrogenase, glyoxysomal precu... 175 2e-42
UniRef50_Q9Y7R8 Cluster: Malate dehydrogenase; n=13; Dikarya|Rep... 163 4e-39
UniRef50_Q9VU29 Cluster: Malate dehydrogenase; n=5; Protostomia|... 159 7e-38
UniRef50_Q86DP2 Cluster: Malate dehydrogenase; n=11; Fungi/Metaz... 155 1e-36
UniRef50_Q4Q3J3 Cluster: Malate dehydrogenase, putative; n=3; Le... 153 6e-36
UniRef50_A2QMH9 Cluster: Malate dehydrogenase; n=7; Fungi/Metazo... 149 1e-34
UniRef50_UPI0000D571DB Cluster: PREDICTED: similar to CG7998-PA;... 145 1e-33
UniRef50_Q6BM17 Cluster: Malate dehydrogenase; n=4; Eukaryota|Re... 138 2e-31
UniRef50_Q5ENS5 Cluster: Malate dehydrogenase; n=1; Heterocapsa ... 125 2e-27
UniRef50_Q017A6 Cluster: Malate dehydrogenase; n=2; cellular org... 124 4e-27
UniRef50_UPI0000DB76D8 Cluster: PREDICTED: similar to CG7998-PA;... 122 2e-26
UniRef50_A7SQS1 Cluster: Predicted protein; n=1; Nematostella ve... 111 2e-23
UniRef50_P32419 Cluster: Malate dehydrogenase, peroxisomal; n=24... 109 1e-22
UniRef50_Q4QDF0 Cluster: Glycosomal malate dehydrogenase; n=9; T... 107 3e-22
UniRef50_Q4Q3J5 Cluster: Malate dehydrogenase, putative; n=5; Tr... 102 1e-20
UniRef50_Q6FL22 Cluster: Malate dehydrogenase; n=1; Candida glab... 102 1e-20
UniRef50_A7TL95 Cluster: Putative uncharacterized protein; n=1; ... 101 2e-20
UniRef50_P22133 Cluster: Malate dehydrogenase, cytoplasmic; n=3;... 98 2e-19
UniRef50_UPI00015B5ACF Cluster: PREDICTED: similar to ENSANGP000... 98 3e-19
UniRef50_UPI0000D55CD8 Cluster: PREDICTED: similar to Malate DeH... 95 2e-18
UniRef50_A7TSF5 Cluster: Putative uncharacterized protein; n=1; ... 95 2e-18
UniRef50_Q6CP51 Cluster: Similar to sp|P22133 Saccharomyces cere... 92 2e-17
UniRef50_Q75AT4 Cluster: ADL164Cp; n=2; Saccharomycetales|Rep: A... 91 5e-17
UniRef50_UPI00015B4591 Cluster: PREDICTED: similar to mitochondr... 86 1e-15
UniRef50_Q3J7E7 Cluster: Malate dehydrogenase; n=5; Gammaproteob... 71 5e-11
UniRef50_UPI0000D56DC5 Cluster: PREDICTED: similar to Malate deh... 69 2e-10
UniRef50_O67655 Cluster: Malate dehydrogenase 1; n=3; Bacteria|R... 66 1e-09
UniRef50_A2SSY4 Cluster: L-lactate dehydrogenase; n=3; Methanomi... 64 4e-09
UniRef50_UPI0000DB6C4F Cluster: PREDICTED: similar to Malate DeH... 62 2e-08
UniRef50_Q64P62 Cluster: Malate dehydrogenase; n=28; Bacteroidet... 60 6e-08
UniRef50_P16115 Cluster: L-lactate dehydrogenase; n=4; Thermotog... 60 6e-08
UniRef50_A7I2F1 Cluster: Malate dehydrogenase; n=1; Campylobacte... 59 1e-07
UniRef50_A7U552 Cluster: Mitochondrial malate-dehydrogenase; n=2... 59 1e-07
UniRef50_UPI00005A0834 Cluster: PREDICTED: similar to Malate deh... 58 3e-07
UniRef50_Q7NHJ3 Cluster: Malate dehydrogenase; n=13; cellular or... 57 7e-07
UniRef50_A7GYI6 Cluster: Lactate/malate dehydrogenase, NAD bindi... 56 2e-06
UniRef50_P19869 Cluster: L-lactate dehydrogenase 2; n=17; Bacter... 55 2e-06
UniRef50_A3BMG8 Cluster: Putative uncharacterized protein; n=3; ... 55 3e-06
UniRef50_Q8XP62 Cluster: L-lactate dehydrogenase; n=11; Clostrid... 54 5e-06
UniRef50_A7I5J9 Cluster: L-lactate dehydrogenase precursor; n=1;... 53 9e-06
UniRef50_UPI00015BB1FC Cluster: malate dehydrogenase (NAD); n=1;... 52 3e-05
UniRef50_Q6VVP7 Cluster: Malate dehydrogenase; n=6; Plasmodium|R... 51 5e-05
UniRef50_Q979N9 Cluster: Malate dehydrogenase; n=4; Thermoplasma... 51 5e-05
UniRef50_Q9PHY2 Cluster: Probable malate dehydrogenase; n=12; Ca... 51 5e-05
UniRef50_O26290 Cluster: Malate dehydrogenase; n=2; Methanobacte... 50 6e-05
UniRef50_Q8YJE7 Cluster: Malate dehydrogenase; n=98; Bacteria|Re... 50 6e-05
UniRef50_Q5CYZ2 Cluster: Lactate dehydrogenase, adjacent gene en... 50 8e-05
UniRef50_Q5LXE1 Cluster: Malate dehydrogenase; n=115; cellular o... 50 8e-05
UniRef50_Q98PG4 Cluster: L-lactate dehydrogenase; n=1; Mycoplasm... 50 8e-05
UniRef50_O51114 Cluster: L-lactate dehydrogenase; n=4; Borrelia ... 50 8e-05
UniRef50_Q8TWG5 Cluster: Malate dehydrogenase; n=2; Euryarchaeot... 50 1e-04
UniRef50_Q2S4R2 Cluster: L-lactate dehydrogenase; n=1; Salinibac... 50 1e-04
UniRef50_Q27743 Cluster: L-lactate dehydrogenase; n=17; Apicompl... 48 3e-04
UniRef50_Q18WQ6 Cluster: Malate dehydrogenase, NAD-dependent; n=... 48 3e-04
UniRef50_A3JXA9 Cluster: L-lactate dehydrogenase; n=1; Sagittula... 48 3e-04
UniRef50_P22988 Cluster: L-lactate dehydrogenase A; n=19; Magnol... 48 3e-04
UniRef50_Q81K80 Cluster: L-lactate dehydrogenase 2; n=12; Firmic... 48 3e-04
UniRef50_Q8ZVB2 Cluster: Malate dehydrogenase; n=14; Thermoprote... 48 4e-04
UniRef50_Q6JH30 Cluster: Lactate dehydrogenase; n=3; Plasmodium ... 47 6e-04
UniRef50_UPI0000519EC7 Cluster: PREDICTED: similar to Ecdysone-i... 47 8e-04
UniRef50_Q8IE66 Cluster: Oxidoreductase, putative; n=6; Plasmodi... 47 8e-04
UniRef50_Q6LZI3 Cluster: Malate dehydrogenase; n=5; Methanococcu... 46 0.001
UniRef50_Q9P7P7 Cluster: Probable L-lactate dehydrogenase; n=2; ... 46 0.001
UniRef50_Q7UY63 Cluster: L-lactate/malate dehydrogenase; n=2; Pl... 46 0.001
UniRef50_P20619 Cluster: L-lactate dehydrogenase X; n=14; Bacill... 46 0.001
UniRef50_P59390 Cluster: L-lactate dehydrogenase 2; n=8; Lactoba... 45 0.003
UniRef50_A4L2P0 Cluster: L-lactate dehydrogenase; n=4; Lactobaci... 44 0.004
UniRef50_A7DRG3 Cluster: Lactate/malate dehydrogenase; n=1; Cand... 44 0.005
UniRef50_Q6A9C3 Cluster: L-lactate dehydrogenase; n=2; Propionib... 44 0.007
UniRef50_Q6F0L9 Cluster: L-lactate dehydrogenase; n=6; Mollicute... 44 0.007
UniRef50_Q7NG49 Cluster: L-lactate dehydrogenase; n=4; Cyanobact... 44 0.007
UniRef50_A4A2L6 Cluster: L-lactate dehydrogenase; n=4; Bacteria|... 43 0.010
UniRef50_Q838C9 Cluster: L-lactate dehydrogenase 2; n=9; Bacilli... 43 0.010
UniRef50_Q0UX88 Cluster: L-lactate dehydrogenase; n=2; Phaeospha... 43 0.013
UniRef50_P0C0J4 Cluster: L-lactate dehydrogenase; n=5; Mycoplasm... 43 0.013
UniRef50_UPI000038D9FF Cluster: COG0039: Malate/lactate dehydrog... 42 0.017
UniRef50_A2SNY0 Cluster: Malate/lactate dehydrogenases-like prot... 42 0.017
UniRef50_A5KJY5 Cluster: Putative uncharacterized protein; n=2; ... 42 0.029
UniRef50_Q4SRH5 Cluster: L-lactate dehydrogenase; n=4; Euteleost... 41 0.038
UniRef50_Q03BE6 Cluster: L-lactate dehydrogenase; n=1; Lactobaci... 41 0.051
UniRef50_A2Q223 Cluster: Lactate/malate dehydrogenase, alpha/bet... 41 0.051
UniRef50_P47698 Cluster: L-lactate dehydrogenase; n=2; Mycoplasm... 41 0.051
UniRef50_P50933 Cluster: L-lactate dehydrogenase; n=7; Bacteria|... 40 0.089
UniRef50_A7DSJ4 Cluster: Lactate/malate dehydrogenase; n=1; Cand... 40 0.12
UniRef50_O08349 Cluster: Malate dehydrogenase; n=1; Archaeoglobu... 40 0.12
UniRef50_P0A3M9 Cluster: L-lactate dehydrogenase; n=140; Bacteri... 40 0.12
UniRef50_P07864 Cluster: L-lactate dehydrogenase C chain; n=371;... 40 0.12
UniRef50_A1U9V0 Cluster: Lactate/malate dehydrogenase; n=6; Acti... 38 0.47
UniRef50_Q8I8U4 Cluster: Lactate dehydrogenase; n=3; Eimeriorina... 38 0.47
UniRef50_Q9P4B6 Cluster: L-lactate dehydrogenase A; n=48; Rhizop... 36 1.1
UniRef50_A3DCA4 Cluster: L-lactate dehydrogenase precursor; n=2;... 36 1.4
UniRef50_Q27SQ2 Cluster: Aldo/keto reductase; n=1; Euglena graci... 36 1.4
UniRef50_Q4UJ29 Cluster: L-lactate dehydrogenase, putative; n=2;... 36 1.4
UniRef50_P61973 Cluster: Malate dehydrogenase; n=43; Bacteria|Re... 36 1.4
UniRef50_A5Z9B1 Cluster: Putative uncharacterized protein; n=1; ... 36 1.9
UniRef50_A4M499 Cluster: Redoxin domain protein; n=3; Desulfurom... 36 1.9
UniRef50_A4AQ95 Cluster: Putative uncharacterized protein; n=2; ... 36 1.9
UniRef50_A3ZZ88 Cluster: L-lactate/malate dehydrogenase; n=1; Bl... 36 1.9
UniRef50_Q75DD3 Cluster: ABR094Wp; n=1; Eremothecium gossypii|Re... 35 2.5
UniRef50_Q30PU9 Cluster: Type I secretion membrane fusion protei... 35 3.3
UniRef50_Q380Z7 Cluster: Putative uncharacterized protein; n=1; ... 35 3.3
UniRef50_Q4L941 Cluster: L-lactate dehydrogenase; n=1; Staphyloc... 35 3.3
UniRef50_UPI000049A3E4 Cluster: hypothetical protein 62.t00026; ... 34 4.4
UniRef50_Q8UYV8 Cluster: Polyprotein; n=24; Strawberry mottle vi... 34 4.4
UniRef50_Q1IRL5 Cluster: L-lactate dehydrogenase; n=6; Bacteria|... 34 4.4
UniRef50_A0YP26 Cluster: Sensor protein; n=1; Lyngbya sp. PCC 81... 34 4.4
UniRef50_Q8TZ24 Cluster: Shikimate dehydrogenase; n=11; Archaea|... 34 5.8
UniRef50_Q7XB94 Cluster: Disease relative signal 1; n=2; Oryza s... 33 7.7
UniRef50_Q55AK2 Cluster: AN1-type Zn finger-containing protein; ... 33 7.7
>UniRef50_Q9SN86 Cluster: Malate dehydrogenase, chloroplast
precursor; n=41; cellular organisms|Rep: Malate
dehydrogenase, chloroplast precursor - Arabidopsis
thaliana (Mouse-ear cress)
Length = 403
Score = 193 bits (471), Expect = 5e-48
Identities = 98/315 (31%), Positives = 176/315 (55%), Gaps = 5/315 (1%)
Query: 12 FTTTRSYQVTVVGATSEVGQVXXXXXXXXXXITKLVVHDNKEFTPGVTLDLSQIPSPSRI 71
F SY+V V+GA +GQ ++ L ++D GV DLS +PS++
Sbjct: 77 FKINASYKVAVLGAAGGIGQPLSLLIKMSPLVSTLHLYDIAN-VKGVAADLSHCNTPSQV 135
Query: 72 LGLTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFV 131
TG L LK+ ++++ G+ ++P ++ L N+ +K+++ + +CP F+
Sbjct: 136 RDFTGPSELADCLKDVNVVVIPAGVPRKPGMTRDDLFNINANIVKTLVEAVAENCPNAFI 195
Query: 132 GIVTEPINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVI 191
I++ P+N +P+ AE+++ GVYD KKLFG+T +D +R+ + + NLK D VPVI
Sbjct: 196 HIISNPVNSTVPIAAEVLKKKGVYDPKKLFGVTTLDVVRANTFVSQKKNLKLIDVDVPVI 255
Query: 192 GGHSDKTIVPLLSQAKPTVEMKEKDLEEFTIKLRNCDGMITKAKRGC-IPNLSVAYSSFL 250
GGH+ TI+PLLS+ KP+V +++++E T++++N + AK G LS+AY++
Sbjct: 256 GGHAGITILPLLSKTKPSVNFTDEEIQELTVRIQNAGTEVVDAKAGAGSATLSMAYAAAR 315
Query: 251 FTKSILDALEGSPAKIH-AFVDNNDFGTSYFSSLVNLDKNGVKEMVR--YSEFSKFECDL 307
F +S L AL+G +FV++ +F+S V + KNG++ ++ +++E
Sbjct: 316 FVESSLRALDGDGDVYECSFVESTLTDLPFFASRVKIGKNGLEAVIESDLQGLTEYEQKA 375
Query: 308 IEKSLQQLRKDVSKG 322
+E +L+ + KG
Sbjct: 376 LEALKVELKASIDKG 390
>UniRef50_P40926 Cluster: Malate dehydrogenase, mitochondrial
precursor; n=119; cellular organisms|Rep: Malate
dehydrogenase, mitochondrial precursor - Homo sapiens
(Human)
Length = 338
Score = 186 bits (454), Expect = 5e-46
Identities = 93/311 (29%), Positives = 167/311 (53%), Gaps = 3/311 (0%)
Query: 19 QVTVVGATSEVGQVXXXXXXXXXXITKLVVHDNKEFTPGVTLDLSQIPSPSRILGLTGED 78
+V V+GA+ +GQ +++L ++D TPGV DLS I + + + G G +
Sbjct: 26 KVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAH-TPGVAADLSHIETKAAVKGYLGPE 84
Query: 79 TLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPI 138
L LK D+++ G+ ++P ++ L N+ + ++ + + CP + ++ P+
Sbjct: 85 QLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPV 144
Query: 139 NYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIGGHSDKT 198
N IP+TAE+ + HGVY+ K+FG+T +D +R+ A L VPVIGGH+ KT
Sbjct: 145 NSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKT 204
Query: 199 IVPLLSQAKPTVEMKEKDLEEFTIKLRNCDGMITKAKRGC-IPNLSVAYSSFLFTKSILD 257
I+PL+SQ P V+ + L T +++ + KAK G LS+AY+ F S++D
Sbjct: 205 IIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVD 264
Query: 258 ALEGSPAKIH-AFVDNNDFGTSYFSSLVNLDKNGVKEMVRYSEFSKFECDLIEKSLQQLR 316
A+ G + +FV + + +YFS+ + L K G+++ + + S FE +I ++ +L+
Sbjct: 265 AMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELK 324
Query: 317 KDVSKGRKILE 327
+ KG ++
Sbjct: 325 ASIKKGEDFVK 335
>UniRef50_Q9VU28 Cluster: Malate dehydrogenase; n=3; Sophophora|Rep:
Malate dehydrogenase - Drosophila melanogaster (Fruit
fly)
Length = 349
Score = 186 bits (453), Expect = 7e-46
Identities = 95/309 (30%), Positives = 163/309 (52%), Gaps = 3/309 (0%)
Query: 16 RSYQVTVVGATSEVGQVXXXXXXXXXXITKLVVHDNKEFTPGVTLDLSQIPSPSRILGLT 75
R+ +V VVGA +GQ I +L +HD E G+ DLS I +++G T
Sbjct: 21 RTLKVAVVGAGGGIGQPLSLLLRRCPGIDELALHDLSEMK-GIATDLSHISQTGKVIGFT 79
Query: 76 GEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVT 135
GE LE A+ +D+++ A G+ + P + L+ AN + + + + P + +T
Sbjct: 80 GEKELESAVSGADVVVVAAGMPRLPGMQRDHLMAANGNVAVKVATAISNASPRAHLAFIT 139
Query: 136 EPINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIGGHS 195
P+N ++P AE++ HG +D ++LFGIT +D +RS+ N+ +D +PVIGGH+
Sbjct: 140 NPVNMIVPAAAEVLMAHGTFDSRRLFGITTLDVVRSKKFIGDSMNISPDDVNIPVIGGHA 199
Query: 196 DKTIVPLLSQAKPTVEMKEKDLEEFTIKLRNCDGMITKAKRG-CIPNLSVAYSSFLFTKS 254
TI+PL+SQ +P ++++ T +++ + AK G LS+AY+ F S
Sbjct: 200 GITILPLISQCQPIYRCDLQEIQNLTHRIQEAGTEVVNAKAGKGSATLSMAYAGATFVNS 259
Query: 255 ILDALEGSPAKIH-AFVDNNDFGTSYFSSLVNLDKNGVKEMVRYSEFSKFECDLIEKSLQ 313
+L + G I AFV + +F+S + L K+G+K + + S +E + +EK L
Sbjct: 260 LLRGIAGQDGLIECAFVASKLTDAPFFASPLELGKDGIKRYIPLPQMSDYEKEALEKLLP 319
Query: 314 QLRKDVSKG 322
LR++ +G
Sbjct: 320 ILRQNADEG 328
>UniRef50_P08249 Cluster: Malate dehydrogenase, mitochondrial
precursor; n=514; cellular organisms|Rep: Malate
dehydrogenase, mitochondrial precursor - Mus musculus
(Mouse)
Length = 338
Score = 186 bits (453), Expect = 7e-46
Identities = 94/311 (30%), Positives = 168/311 (54%), Gaps = 3/311 (0%)
Query: 19 QVTVVGATSEVGQVXXXXXXXXXXITKLVVHDNKEFTPGVTLDLSQIPSPSRILGLTGED 78
+V V+GA+ +GQ +++L ++D TPGV DLS I + + + G G +
Sbjct: 26 KVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAH-TPGVAADLSHIETRANVKGYLGPE 84
Query: 79 TLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPI 138
L LK D+++ G+ ++P ++ L N+ + ++ + + CP V I+ P+
Sbjct: 85 QLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMVCIIANPV 144
Query: 139 NYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIGGHSDKT 198
N IP+TAE+ + HGVY+ K+FG+T +D +R+ A L VPVIGGH+ KT
Sbjct: 145 NSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKT 204
Query: 199 IVPLLSQAKPTVEMKEKDLEEFTIKLRNCDGMITKAKRGC-IPNLSVAYSSFLFTKSILD 257
I+PL+SQ P V+ + L T +++ + KAK G LS+AY+ F S++D
Sbjct: 205 IIPLISQCTPKVDFPQDQLATLTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVD 264
Query: 258 ALEGSPAKIH-AFVDNNDFGTSYFSSLVNLDKNGVKEMVRYSEFSKFECDLIEKSLQQLR 316
A+ G + +FV + + +YFS+ + L K G+++ + + + FE +I +++ +L+
Sbjct: 265 AMNGKEGVVECSFVQSKETECTYFSTPLLLGKKGLEKNLGIGKITPFEEKMIAEAIPELK 324
Query: 317 KDVSKGRKILE 327
+ KG ++
Sbjct: 325 ASIKKGEDFVK 335
>UniRef50_Q42972 Cluster: Malate dehydrogenase, glyoxysomal
precursor; n=11; Eukaryota|Rep: Malate dehydrogenase,
glyoxysomal precursor - Oryza sativa subsp. japonica
(Rice)
Length = 356
Score = 175 bits (425), Expect = 2e-42
Identities = 90/307 (29%), Positives = 164/307 (53%), Gaps = 3/307 (0%)
Query: 18 YQVTVVGATSEVGQVXXXXXXXXXXITKLVVHDNKEFTPGVTLDLSQIPSPSRILGLTGE 77
++V ++GA+ +GQ ++ L ++D TPGVT D+S + + + + G G+
Sbjct: 45 FKVAILGASGGIGQPLALLMKMNPLVSVLHLYDVVN-TPGVTADISHMNTGAVVRGFLGQ 103
Query: 78 DTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEP 137
LE AL DL+I G+ ++P ++ L N+ ++++ + + CP V +++ P
Sbjct: 104 PQLENALTGMDLVIIPAGVPRKPGMTRDDLFNINAGIVRTLCEGIAKCCPNAIVNVISNP 163
Query: 138 INYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIGGHSDK 197
+N +P+ AE+ + G YD K+L G+T +D +R+ A L D VPVIGGH+
Sbjct: 164 VNSTVPIAAEVFKKAGTYDPKRLLGVTTLDVVRANTFVAEVLGLDPRDVNVPVIGGHAGV 223
Query: 198 TIVPLLSQAKPTVEMKEKDLEEFTIKLRNCDGMITKAKRGC-IPNLSVAYSSFLFTKSIL 256
TI+PLLSQ P +++ T +++N + +AK G LS+AY++ F + L
Sbjct: 224 TILPLLSQVNPPCSFTSEEISYLTTRIQNGGTEVVEAKAGAGSATLSMAYAASKFADACL 283
Query: 257 DALEGSPAKIH-AFVDNNDFGTSYFSSLVNLDKNGVKEMVRYSEFSKFECDLIEKSLQQL 315
L G + +FV + +F+S V L + G++E++ ++FE +EK+ ++L
Sbjct: 284 RGLRGDAGIVECSFVASQVTELPFFASKVRLGRCGIEEILSLGPLNEFERAGLEKAKKEL 343
Query: 316 RKDVSKG 322
+ + KG
Sbjct: 344 AESIQKG 350
>UniRef50_Q9Y7R8 Cluster: Malate dehydrogenase; n=13; Dikarya|Rep:
Malate dehydrogenase - Schizosaccharomyces pombe
(Fission yeast)
Length = 341
Score = 163 bits (397), Expect = 4e-39
Identities = 96/320 (30%), Positives = 172/320 (53%), Gaps = 9/320 (2%)
Query: 13 TTTRSYQVTVVGATSEVGQVXXXXXXXXXXITKLVVHDNKEFTPGVTLDLSQIPSPSRIL 72
T++R+++V V+GA +GQ +++L + D + PGV D+ I + S ++
Sbjct: 24 TSSRAFKVAVLGAGGGIGQPLSMLLKLNDKVSELALFDIRG-APGVAADIGHINTTSNVV 82
Query: 73 GLTGEDT-LERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFV 131
G +D LE+AL +D++I G+ ++P ++ L N+ ++ + G +CP
Sbjct: 83 GYAPDDKGLEKALNGADVVIIPAGVPRKPGMTRDDLFATNASIVRDLAFAAGETCPEAKY 142
Query: 132 GIVTEPINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVI 191
+VT P+N +P+ + + GV+ K LFG+T +D++R+ + N KA ++PV+
Sbjct: 143 LVVTNPVNSTVPIFKKALERVGVHQPKHLFGVTTLDSVRASRFTSQVTNGKAELLHIPVV 202
Query: 192 GGHSDKTIVPLLSQAKPTVEMKEKDLEEFTIKLRNCDGMITKAKRGC-IPNLSVAYSSFL 250
GGHS TIVPLLSQ VE+ + + +++ + KAK G LS+AY+
Sbjct: 203 GGHSGATIVPLLSQG--GVELTGEKRDALIHRIQFGGDEVVKAKAGAGSATLSMAYAGAR 260
Query: 251 FTKSILDALEG-SPAKIHAFVDN---NDFGTSYFSSLVNLDKNGVKEMVRYSEFSKFECD 306
S+L AL G S + FV++ D G +F+S V L K+GV + + + +E
Sbjct: 261 MASSVLRALAGESGVEECTFVESPLYKDQGIDFFASRVTLGKDGVDTIHPVGKINDYEES 320
Query: 307 LIEKSLQQLRKDVSKGRKIL 326
L++ +L +L+K ++KG + +
Sbjct: 321 LLKVALGELKKSITKGEQFV 340
>UniRef50_Q9VU29 Cluster: Malate dehydrogenase; n=5;
Protostomia|Rep: Malate dehydrogenase - Drosophila
melanogaster (Fruit fly)
Length = 347
Score = 159 bits (387), Expect = 7e-38
Identities = 90/324 (27%), Positives = 166/324 (51%), Gaps = 5/324 (1%)
Query: 8 ISSLFTTTRSYQVTVVGATSEVGQVXXXXXXXXXXITKLVVHDNKEFTPGVTLDLSQIPS 67
+ L R +V VVG+ +GQ I+ L ++D K T GV +DLS I +
Sbjct: 18 VQQLGYINRGLKVAVVGSVGGIGQPLSLLLKHNPQISTLSLYDIKN-TTGVGVDLSHINT 76
Query: 68 PSRILGLTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCP 127
+ + G++ L++A+ +D+++ GL ++P + + L+ N+ + CP
Sbjct: 77 RASVCPFEGKNGLKKAMDKADIVVIPAGLPRKPGMKREDLVDVNASVACEVAFAASEVCP 136
Query: 128 IPFVGIVTEPINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCY 187
+ +T PIN ++P+ A I++ G YD +LFG+T +D +R+Q A N+
Sbjct: 137 GAMLAFITNPINVIVPIVATILKAKGTYDPNRLFGVTTLDVVRAQTFVADILNVDPQKVN 196
Query: 188 VPVIGGHSDKTIVPLLSQAKPTVEMKEKDLEEFTIKLRNCDGMITKAKRGC-IPNLSVAY 246
+PVIGGH+ +TI+P+LSQ P + +K+ E +++N + AK G LS+A+
Sbjct: 197 IPVIGGHTGRTILPILSQCDPPFKGTDKEREALIQRIQNAGTEVVNAKDGLGSATLSMAF 256
Query: 247 SSFLFTKSILDALEGSPAKI---HAFVDNNDFGTSYFSSLVNLDKNGVKEMVRYSEFSKF 303
++ F S++ ++GS + A+V+++ +F++ + L GVKE +
Sbjct: 257 AATQFVSSLIKGIKGSKDECIVECAYVESDVTEAQFFATPLILGPQGVKENTGLPDLDDE 316
Query: 304 ECDLIEKSLQQLRKDVSKGRKILE 327
E + L L++ ++KG K+ E
Sbjct: 317 ERKALNGMLPILKESIAKGIKLGE 340
>UniRef50_Q86DP2 Cluster: Malate dehydrogenase; n=11; Fungi/Metazoa
group|Rep: Malate dehydrogenase - Plicopurpura patula
Length = 229
Score = 155 bits (377), Expect = 1e-36
Identities = 70/222 (31%), Positives = 132/222 (59%), Gaps = 2/222 (0%)
Query: 107 LLTANSQFIKSIISKLGRSCPIPFVGIVTEPINYLIPMTAEIMRNHGVYDEKKLFGITEI 166
L N+ ++ + ++ + CP +GI+T P+N +P+ +E+++ GVYD K++FG+T +
Sbjct: 2 LFNTNAGIVRDLTDRIAKVCPTAMLGIITNPVNSTVPIASEVLKKRGVYDPKRVFGVTTL 61
Query: 167 DAIRSQCLYATENNLKANDCYVPVIGGHSDKTIVPLLSQAKPTVEMKEKDLEEFTIKLRN 226
D +RS A L VPVIGGHS TI+PL+SQ P V ++ E+ +++++N
Sbjct: 62 DVVRSNTFIAEAKGLDVTKTNVPVIGGHSGVTIIPLISQCTPPVSFPTEEREKLSVRIQN 121
Query: 227 CDGMITKAKRGC-IPNLSVAYSSFLFTKSILDALEGSPAKIH-AFVDNNDFGTSYFSSLV 284
+ +AK G LS+AY++ F +S+++AL G + AFV +++ +YF++ +
Sbjct: 122 AGTEVVEAKAGAGSATLSMAYAAAEFCRSLIEALNGKERVVQCAFVKSDETEAAYFATPL 181
Query: 285 NLDKNGVKEMVRYSEFSKFECDLIEKSLQQLRKDVSKGRKIL 326
L KNGV++ + + FE +L++ ++ +L ++ KG + +
Sbjct: 182 LLGKNGVEKNLGLGKLIDFEVNLLKAAMPELIANIKKGEEFV 223
>UniRef50_Q4Q3J3 Cluster: Malate dehydrogenase, putative; n=3;
Leishmania|Rep: Malate dehydrogenase, putative -
Leishmania major
Length = 331
Score = 153 bits (371), Expect = 6e-36
Identities = 87/314 (27%), Positives = 172/314 (54%), Gaps = 8/314 (2%)
Query: 13 TTTRSYQVTVVGATSEVGQVXXXXXXXXXXITKLVVHDNKEFTPGVTLDLSQIPSPSRIL 72
+T ++VTV+GA+ +GQ +++L ++D + GV +DLS P ++
Sbjct: 4 STLSRFKVTVLGASGAIGQPLALALVQNKRVSELALYDIVQ-PRGVAVDLSHFPRKVKVT 62
Query: 73 GLTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVG 132
G + + +AL +DL++ + G+ +RP ++ L N+ + + + + R P +
Sbjct: 63 GYPTK-WIHKALDGADLVLMSAGMPRRPGMTHDDLFNTNALTVNELSAAVARYAPKSVLA 121
Query: 133 IVTEPINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIG 192
I++ P+N ++P+ AE ++ GVYD +KLFGI ++ +R++ + VPVIG
Sbjct: 122 IISNPLNSMVPVAAETLQRAGVYDPRKLFGIISLNMMRARKMLGDFTGQDPEMLDVPVIG 181
Query: 193 GHSDKTIVPLLSQAKPTVEMKEKDLEEFTIKLRNCDGMITKAKRG-CIPNLSVAYSSFLF 251
GHS +TIVPL S + VE++++ +E T ++R + KAK G +LS+A+++ +
Sbjct: 182 GHSGQTIVPLFSHS--GVELRQEQVEYLTHRVRVGGDEVVKAKEGRGSSSLSMAFAAAEW 239
Query: 252 TKSILDALEGSPAKIH-AFVDNNDFGTS--YFSSLVNLDKNGVKEMVRYSEFSKFECDLI 308
+L A++G + +FV++ F +F S V + K G++ ++ +++E + +
Sbjct: 240 ADGVLRAMDGEKTLLQCSFVESPLFADKCRFFGSTVEVCKEGIERVLPLPPLNEYEEEQL 299
Query: 309 EKSLQQLRKDVSKG 322
++ L L K++ KG
Sbjct: 300 DRCLPDLEKNIRKG 313
>UniRef50_A2QMH9 Cluster: Malate dehydrogenase; n=7; Fungi/Metazoa
group|Rep: Malate dehydrogenase - Aspergillus niger
Length = 340
Score = 149 bits (361), Expect = 1e-34
Identities = 94/318 (29%), Positives = 169/318 (53%), Gaps = 12/318 (3%)
Query: 13 TTTRSYQVTVVGATSEVGQVXXXXXXXXXXITKLVVHDNKEFTPGVTLDLSQIPSPSRIL 72
+ +++ +V V+GA +GQ +T L ++D + PGV D+S I + S +
Sbjct: 19 SASQASKVAVLGAAGGIGQPLSLLMKQNPLVTDLALYDIRG-GPGVAADISHINTNSTVK 77
Query: 73 GLTGEDT-LERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFV 131
G + L ALK S++I+ G+ ++P ++ L N+ ++ + + P +
Sbjct: 78 GYEPTPSGLRDALKGSEIILIPAGVPRKPGMTRDDLFNTNASIVRDLAKAAAEAAPEANI 137
Query: 132 GIVTEPINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIR-SQCLYATENNLKANDCYVPV 190
+++ P+N +P+ +E+ ++ GVY+ K+LFG+T +D +R S+ + + AN+ V V
Sbjct: 138 LVISNPVNSTVPIVSEVYKSKGVYNPKRLFGVTTLDVVRASRFISQVKGTNPANEA-VTV 196
Query: 191 IGGHSDKTIVPLLSQAK-PTVEMKEKDLEEFTIKLRNCDGMITKAKRGC-IPNLSVAYSS 248
IGGHS TIVPLLSQ+ P + +D E +++ + KAK G LS+A +
Sbjct: 197 IGGHSGVTIVPLLSQSNHPDISGTVRD--ELVNRIQFGGDEVVKAKDGAGSATLSMAMAG 254
Query: 249 FLFTKSILDALEGSPAKIH-AFVDN---NDFGTSYFSSLVNLDKNGVKEMVRYSEFSKFE 304
F S+L A G + FV++ D G ++F+S V L NGV+++ +++E
Sbjct: 255 ARFADSLLRAANGEKGIVEPTFVESPLFKDQGVNFFASKVELGPNGVEKIHEVGPVNEYE 314
Query: 305 CDLIEKSLQQLRKDVSKG 322
LI+ +L L+K++ KG
Sbjct: 315 QGLIQTALGDLKKNIQKG 332
>UniRef50_UPI0000D571DB Cluster: PREDICTED: similar to CG7998-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG7998-PA - Tribolium castaneum
Length = 376
Score = 145 bits (352), Expect = 1e-33
Identities = 87/315 (27%), Positives = 160/315 (50%), Gaps = 4/315 (1%)
Query: 13 TTTRSYQVTVVGATSEVGQVXXXXXXXXXXITKLVVHDNKEFTPGVTLDLSQIPSPSRIL 72
+++ + +VT++GA G+ I +L ++D + G DL+ + + R+
Sbjct: 24 SSSTTMKVTILGAGGNTGKSVSLMLKQSPFIDELCLYDTQSLE-GFANDLNYVDTKCRVT 82
Query: 73 GLTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVG 132
G +++AL S++I+ + +L N+ +K + + + + P V
Sbjct: 83 SFFGNKDIQKALTKSNIIVVLSCCHAAEPTNYASLFDRNAPIVKDLATSIAKFSPKSTVA 142
Query: 133 IVTEPINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIG 192
I EPIN ++PM +EIM+ +G Y+ +FGIT +D +R+ A L+ VP++G
Sbjct: 143 IGVEPINSVVPMFSEIMKKYGHYNPYSIFGITTVDVVRTNKFVAEILGLEPECVTVPIVG 202
Query: 193 GHSDKTIVPLLSQAKPTVEMKEKDLEEFTIKLRNCDGMITKAKRGCIPNLSVAYSSFLFT 252
GHS+KTIVP+LSQAKP E+ ++LE+ TI +R + + K R L+ A++ F
Sbjct: 203 GHSEKTIVPVLSQAKPCNELTNEELEDITISVRKANEHLLKV-RSDGAYLASAFAVSRFV 261
Query: 253 KSILDALEGSPAKIH-AFVDNNDF-GTSYFSSLVNLDKNGVKEMVRYSEFSKFECDLIEK 310
S++ A G + ++V +N Y + + L GV + + E S +E L+E
Sbjct: 262 ISLVKAARGQNEIVECSYVKSNVHPQLKYMVTPLLLGPGGVAKNLGLPELSDYETCLLEN 321
Query: 311 SLQQLRKDVSKGRKI 325
++ L +++ KG +
Sbjct: 322 AIPVLAEEIKKGEYV 336
>UniRef50_Q6BM17 Cluster: Malate dehydrogenase; n=4; Eukaryota|Rep:
Malate dehydrogenase - Debaryomyces hansenii (Yeast)
(Torulaspora hansenii)
Length = 346
Score = 138 bits (333), Expect = 2e-31
Identities = 80/258 (31%), Positives = 139/258 (53%), Gaps = 19/258 (7%)
Query: 19 QVTVVGATSEVGQVXXXXXXXXXXITKLVVHDNKEFTPGVTLDLSQIPSPSRILGLT--- 75
+VTV GA +GQ +++L + D GV DLS I SP+++ G
Sbjct: 3 KVTVCGAAGGIGQPLSLLLKLNPQVSELSLFDVVNAN-GVAADLSHICSPAKVTGYQPSS 61
Query: 76 --GEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGI 133
DT+++AL NSDL++ G+ ++P ++ L N+ I+ I+ +G++CP + I
Sbjct: 62 KEDRDTIQKALVNSDLVVIPAGVPRKPGMTRADLFNINASIIRDIVGSIGKACPNAAILI 121
Query: 134 VTEPINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRS-----QCLYATENNLKANDCYV 188
++ P+N +P+ AE+++ GV++ KKLFG+T +D++R+ + + T +LK +
Sbjct: 122 ISNPVNSTVPIAAEVLKKLGVFNPKKLFGVTTLDSVRAETFLGELIKETPTSLKGQ---I 178
Query: 189 PVIGGHSDKTIVPLLSQ----AKPTVEMKEKDLEEFTIKLRNCDGMITKAKRGC-IPNLS 243
VIGGHS TIVPL+ AK + + EF +++ + KAK G LS
Sbjct: 179 SVIGGHSGDTIVPLVHATALVAKKVSGLSKSQYNEFIHRVQFGGDEVVKAKNGAGSATLS 238
Query: 244 VAYSSFLFTKSILDALEG 261
+AY+ + F + ++ +L G
Sbjct: 239 MAYAGYRFAEKVIGSLNG 256
>UniRef50_Q5ENS5 Cluster: Malate dehydrogenase; n=1; Heterocapsa
triquetra|Rep: Malate dehydrogenase - Heterocapsa
triquetra (Dinoflagellate)
Length = 402
Score = 125 bits (301), Expect = 2e-27
Identities = 84/323 (26%), Positives = 144/323 (44%), Gaps = 12/323 (3%)
Query: 15 TRSYQVTVVGATSEVGQVXXXXXXXXXXITKLVVHD-NKEFTP--GVTLDLSQIPSPSRI 71
T ++V V G +GQ + +L V D N P GV DL + + +
Sbjct: 78 TGEFKVCVCGGAGGIGQPLCLLMAMDPNVKELCVFDLNVAMVPAQGVATDLGHLEKKAAV 137
Query: 72 LGLTGE------DTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRS 125
G E D LE L L++ G+ ++P + L N+ K I+ +
Sbjct: 138 KGYVMEVGQKPVDNLEECLTGCHLVLIPAGMPRKPGQTRDDLFKINADIAKGIVEACAKY 197
Query: 126 CPIPFVGIVTEPINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKAND 185
CP +G++ P+N ++P AE+ + G+ D K+ GIT +D +R+ + +
Sbjct: 198 CPDAMLGMIVNPVNSVVPAMAELYKKKGL-DPMKIVGITTLDVVRAN-KFVVRLPAPPDR 255
Query: 186 CYVPVIGGHSDKTIVPLLSQAKPTVEMKEKDLEEFTIKLRNCDGMITKAKRG-CIPNLSV 244
VPVIGGH+ TI+PL SQ K + + + + +++ + AK G LS+
Sbjct: 256 VNVPVIGGHAGTTILPLFSQDKHAKTIDAEKIPDLDKHVQDAGTDVVNAKNGKGSATLSM 315
Query: 245 AYSSFLFTKSILDALEGSPAKIHAFVDNNDFGTSYFSSLVNLDKNGVKEMVRYSEFSKFE 304
AY+ KS+L L G A+ + YF+ V K G+ +++ E +++E
Sbjct: 316 AYAGARLGKSVLAGLAGQRRTECAYCKSEITDLPYFAQKVVFGKEGISKVLPLGELNEYE 375
Query: 305 CDLIEKSLQQLRKDVSKGRKILE 327
+E+ QL+ ++ G K E
Sbjct: 376 TKRLEEVKVQLKGEIESGLKYAE 398
>UniRef50_Q017A6 Cluster: Malate dehydrogenase; n=2; cellular
organisms|Rep: Malate dehydrogenase - Ostreococcus tauri
Length = 477
Score = 124 bits (298), Expect = 4e-27
Identities = 65/212 (30%), Positives = 113/212 (53%), Gaps = 3/212 (1%)
Query: 107 LLTANSQFIKSIISKLGRSCPIPFVGIVTEPINYLIPMTAEIMRNHGVYDEKKLFGITEI 166
L N +K ++ + +CP + +++ P+N +P+ AE+++ G YD KKLFG+T +
Sbjct: 6 LFAINGGIVKGLVEAIADNCPNAMINMISNPVNSTVPIAAEVLKAKGKYDPKKLFGVTTL 65
Query: 167 DAIRSQCLYATENNLKANDCYVPVIGGHSDKTIVPLLSQAKPTVE-MKEKDLEEFTIKLR 225
D +R++ YA + L+ + VPV+GGH+ TI+PL SQA P + + D++ T + +
Sbjct: 66 DVVRAKTFYAEKAGLETSKVDVPVVGGHAGITILPLFSQATPQAKNLSADDIDALTKRTQ 125
Query: 226 NCDGMITKAKRG-CIPNLSVAYSSFLFTKSILDALEGSPAKIH-AFVDNNDFGTSYFSSL 283
+ + AK G LS+AY+ LF + L A G + +V++ YFSS
Sbjct: 126 DGGTEVVAAKAGKGSATLSMAYAGALFADACLRAKNGEANIVECTYVESKVTKVPYFSSK 185
Query: 284 VNLDKNGVKEMVRYSEFSKFECDLIEKSLQQL 315
V L ++GV + S +E ++ + QL
Sbjct: 186 VTLGRDGVDTVHGLGTLSAYEQSALDAMMPQL 217
>UniRef50_UPI0000DB76D8 Cluster: PREDICTED: similar to CG7998-PA;
n=2; Apis mellifera|Rep: PREDICTED: similar to CG7998-PA
- Apis mellifera
Length = 333
Score = 122 bits (293), Expect = 2e-26
Identities = 71/311 (22%), Positives = 156/311 (50%), Gaps = 7/311 (2%)
Query: 19 QVTVVGATSEVGQVXXXXXXXXXXITKLVVHDNKEFTPGVTLDLSQIPSPSRILGLTG-E 77
+V ++GA S+ G I +L + DN T G+ LDL+ I + ++ E
Sbjct: 2 KVAILGARSKTGNCLSLFLKQSPLIDELAIFDNNSSTYGLALDLNYIDTKCKVSTCNHPE 61
Query: 78 DTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEP 137
LE L+ + +++ ++ R +L +N+ + ++ + + P + IV P
Sbjct: 62 KCLEETLQGAKIVMI---VTDRTSNESNEVLKSNAIILSDLLPNIIKFSPQAMLAIVMNP 118
Query: 138 INYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIGGHSDK 197
IN LIP+T E+ + G+Y+ ++FG+ + +++ A N++ +PVIGG +
Sbjct: 119 INSLIPLTMEMYKKAGIYEYNRIFGVMNFECLKANSFTADLINIEPECTMIPVIGGGCSE 178
Query: 198 TIVPLLSQAKPTVEMKEKDLEEFTIKLR-NCDGMITKAKRGCIPNLSVAYSSFLFTKSIL 256
T +PL SQAKP+ ++ + + T +R + + + ++ + +++Y++ F S+
Sbjct: 179 TCIPLFSQAKPSNKISQVEARRLTYAIRMSNNNTLNPSENKETNSFALSYAAARFCMSLC 238
Query: 257 DALEGSPAKIH-AFVDNNDF-GTSYFSSLVNLDKNGVKEMVRYSEFSKFECDLIEKSLQQ 314
AL + A+V + +YF++ + L NG+++ + + +EC+L++ ++ +
Sbjct: 239 KALRHQGNVVECAYVRSCAIPELTYFAAPLELGPNGIQKHLDIPPLNDYECELLKAAVPR 298
Query: 315 LRKDVSKGRKI 325
++K + G +
Sbjct: 299 IKKAIKLGETL 309
>UniRef50_A7SQS1 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 254
Score = 111 bits (267), Expect = 2e-23
Identities = 67/271 (24%), Positives = 131/271 (48%), Gaps = 28/271 (10%)
Query: 54 FTPGVTLDLSQIPSPSRILGLTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQ 113
F+ GV DLS I + +++ G D L+ AL+ ++ G+ ++P ++ L N+
Sbjct: 4 FSVGVAADLSHISTRAKVTSHQGPDDLKAALEGCSVVAIPAGVPRKPGMTRDDLFNTNAS 63
Query: 114 FIKSIISKLGRSCPIPFVGIVTEPINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQC 173
+K++ + CP + I++ P+N +P+ +E+ + GVYD ++ G+T +D +R+
Sbjct: 64 IVKNLSEACAKHCPKAIICIISNPVNSTVPIASEVYKKAGVYDPARILGVTTLDIVRAHT 123
Query: 174 LYATENNLKANDCYVPVIGGHSDKTIVPLLSQAKPTVEMKEKDLEEFTIKLRNCDGMITK 233
A ++ P V + DLE+ T +++N +
Sbjct: 124 FVAE--------------------------AKTTPCVNFTQDDLEKLTDRIQNAGTEVVN 157
Query: 234 AKRGC-IPNLSVAYSSFLFTKSILDALEGSPAKIH-AFVDNNDFGTSYFSSLVNLDKNGV 291
AK G LS+AY+ F S+++AL G + AF+ ++ YF++ V L NGV
Sbjct: 158 AKAGAGSATLSMAYAGKEFVHSVIEALNGKKDVVQCAFIKSHLTEAGYFATPVLLGTNGV 217
Query: 292 KEMVRYSEFSKFECDLIEKSLQQLRKDVSKG 322
++ + + S +E + + + +L K++ KG
Sbjct: 218 EKNLGMGKLSDYEQKKMGEVIPELLKNIKKG 248
>UniRef50_P32419 Cluster: Malate dehydrogenase, peroxisomal; n=24;
Eukaryota|Rep: Malate dehydrogenase, peroxisomal -
Saccharomyces cerevisiae (Baker's yeast)
Length = 343
Score = 109 bits (262), Expect = 1e-22
Identities = 85/339 (25%), Positives = 163/339 (48%), Gaps = 35/339 (10%)
Query: 19 QVTVVGATSEVGQVXXXXXXXXXXITKLVVHDNKEFTPGVTLDLSQIPSPSRILGLTGED 78
+V ++GA+ VGQ +++L ++D + G+ DLS I + S +G +D
Sbjct: 3 KVAILGASGGVGQPLSLLLKLSPYVSELALYDIRA-AEGIGKDLSHINTNSSCVGYD-KD 60
Query: 79 TLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPI 138
++E L N+ +++ G+ ++P ++ L N+ +KS+++ +G+ P + +++ P+
Sbjct: 61 SIENTLSNAQVVLIPAGVPRKPGLTRDDLFKMNAGIVKSLVTAVGKFAPNARILVISNPV 120
Query: 139 NYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCL---YATENNLKAND--------CY 187
N L+P+ E ++ G + + G+T +D +R++ Y N K
Sbjct: 121 NSLVPIAVETLKKMGKFKPGNVMGVTNLDLVRAETFLVDYLMLKNPKIGQEQDKTTMHRK 180
Query: 188 VPVIGGHSDKTIVPLLSQAKPTVEMKEKDLEEFTIKLRNCDGMITKAKRGC-IPNLSVAY 246
V VIGGHS +TI+P+++ K V +K E F +++ I KAK+G LS+A+
Sbjct: 181 VTVIGGHSGETIIPIITD-KSLVFQLDKQYEHFIHRVQFGGDEIVKAKQGAGSATLSMAF 239
Query: 247 SSFLFTKSILDALEGSPAK---IHAFV-----DN--------NDFGTSYFSSLVNLDKNG 290
+ F + +L + + + AFV N D YFS + L +NG
Sbjct: 240 AGAKFAEEVLRSFHNEKPETESLSAFVYLPGLKNGKKAQQLVGDNSIEYFSLPIVL-RNG 298
Query: 291 VKEMVRYSEFSKF---ECDLIEKSLQQLRKDVSKGRKIL 326
+ S K E L+ ++++LRK++ KG+ +
Sbjct: 299 SVVSIDTSVLEKLSPREEQLVNTAVKELRKNIEKGKSFI 337
>UniRef50_Q4QDF0 Cluster: Glycosomal malate dehydrogenase; n=9;
Trypanosomatidae|Rep: Glycosomal malate dehydrogenase -
Leishmania major
Length = 322
Score = 107 bits (258), Expect = 3e-22
Identities = 81/313 (25%), Positives = 143/313 (45%), Gaps = 12/313 (3%)
Query: 20 VTVVGATSEVGQVXXXXXXXXXXITKLVVHDNKEFTPGVTLDLS-------QIPSPSRIL 72
V VVGA +GQ + + GV DLS Q+ +
Sbjct: 4 VCVVGAAGGIGQSLSLLLVRQLPYGSTLSLFDVVGAAGVAADLSHVDNAGVQVKFAEGKI 63
Query: 73 GLTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVG 132
G + L K D+ + G+ ++P ++ L N+ I ++ S P
Sbjct: 64 GHKRDPALAELAKGVDVFVMVAGVPRKPGMTRDDLFKINAGIILDLVLTCASSSPKAVFC 123
Query: 133 IVTEPINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIG 192
IVT P+N + + AE +++ GVYD +L G++ +D +R+ C + E VPV+G
Sbjct: 124 IVTNPVNSTVAIAAEALKSLGVYDRNRLLGVSLLDGLRATC-FINEARKPLVVSQVPVVG 182
Query: 193 GHSDKTIVPLLSQAKPTVEMKEKDLEEFTIKLRNCDGMITKAKRG-CIPNLSVAYSSFLF 251
GHSD TIVPL Q P ++ L++ +++ + KAK G LS+A + F
Sbjct: 183 GHSDTTIVPLFYQL-PGPLPEQATLDKIVKRVQVAGTEVVKAKAGRGSATLSMAEAGARF 241
Query: 252 TKSILDALEGS-PAKIHAFVD-NNDFGTSYFSSLVNLDKNGVKEMVRYSEFSKFECDLIE 309
+++ L G+ ++A+VD + T++ + V L NG+++ + E L++
Sbjct: 242 ALKVVEGLTGTGNPLVYAYVDTDGQHETTFLAIPVVLGMNGIEKRLPIGPLHSTEETLLK 301
Query: 310 KSLQQLRKDVSKG 322
+L ++K++ KG
Sbjct: 302 AALPVIKKNIVKG 314
>UniRef50_Q4Q3J5 Cluster: Malate dehydrogenase, putative; n=5;
Trypanosomatidae|Rep: Malate dehydrogenase, putative -
Leishmania major
Length = 342
Score = 102 bits (245), Expect = 1e-20
Identities = 83/326 (25%), Positives = 154/326 (47%), Gaps = 16/326 (4%)
Query: 13 TTTRSYQVTVVGATSEVGQVXXXXXXXXXXITKLV----VHDNKEFTPGVTLDLSQIPSP 68
T + +V + G ++ VGQ + +LV D+ G+ DLS I +
Sbjct: 10 TALKKGKVVLFGCSNAVGQPLSLLLKMNPHVEELVCCNTAADDDVPGSGIAADLSHIDTL 69
Query: 69 SRILGLTGEDTLERALKNSDLIIAAGGLSQRPDISEKAL-LTANSQFIKSIISKLGRSCP 127
++ T E L+++ LI+ G S ++ + L A + ++ +++ + S
Sbjct: 70 PKVHYATDEGQWPALLRDAQLILVCFGSSFDLLREDRDIALKAAAPTMRRVMAAVASSDT 129
Query: 128 IPFVGIVTEPINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCY 187
V +V+ P+N L P AE+++ G +D +KLFG+T +D IR++ L A ++ D
Sbjct: 130 TGNVAVVSSPVNALTPFCAELLKASGKFDPRKLFGVTTLDVIRTRKLVAGTLHMNPYDVN 189
Query: 188 VPVIGGHSDKTIVPLLSQAKPTVEMKE-----KDLEEFTIKLR---NCDGMITKAKRGCI 239
VPV+GG T PL++Q + + + +++ + + D +
Sbjct: 190 VPVVGGCGGVTACPLIAQTGLRIPLDDIVRISGEVQSYGVLFEAAVGADSHDALSTEVAP 249
Query: 240 P-NLSVAYSSFLFTKSILDALEGSPAKIH-AFVDNN-DFGTSYFSSLVNLDKNGVKEMVR 296
P L +AY++ F+ S+L AL G + A V++ T +FSS V L + GV+ +
Sbjct: 250 PVALGLAYAACDFSTSLLKALRGDVGIVECALVESTMRSETPFFSSRVELGREGVQRVFP 309
Query: 297 YSEFSKFECDLIEKSLQQLRKDVSKG 322
+ +E +LIE ++ +L +DV G
Sbjct: 310 MGALTSYEHELIETAVPELMRDVQAG 335
>UniRef50_Q6FL22 Cluster: Malate dehydrogenase; n=1; Candida
glabrata|Rep: Malate dehydrogenase - Candida glabrata
(Yeast) (Torulopsis glabrata)
Length = 373
Score = 102 bits (245), Expect = 1e-20
Identities = 73/262 (27%), Positives = 130/262 (49%), Gaps = 23/262 (8%)
Query: 19 QVTVVGATSEVGQVXXXXXXXXXXITKLVVHDNKEFTPGVTLDLSQIPSPSRILGLTGED 78
+V V+GA+ VGQ I++L ++D K GV DLS I + + +G + +D
Sbjct: 3 KVAVLGASGGVGQPLSLLLKLNTMISELALYDIK-LAEGVATDLSHINTNADCVGYSTDD 61
Query: 79 TLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPI 138
+ +ALK + +++ G+ +RP I+ L N+ +K+++S + + CP + I++ P+
Sbjct: 62 -IGQALKGAAVVVIPAGVPRRPGITRDDLFKLNAGIVKNLVSNVAKHCPNARLLIISNPV 120
Query: 139 NYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATE-NNLKANDC----------- 186
N LIP+ E ++ GV+ + G+T +D +R++ A N +A +
Sbjct: 121 NSLIPVAVETLKRCGVFQAGNVMGVTTLDLVRAETFLAEYLNTHEAKEIGGIAGERTYDK 180
Query: 187 -----YVPVIGGHSDKTIVPLLSQAKPTVEM-KEKDLEEFTIKLRNCDGMITKAKR---G 237
YV VIGGHS +TIVPL+ T + K +EF +++ + KAK
Sbjct: 181 SKMYKYVGVIGGHSGETIVPLVFNHMMTRTLEKTNKYDEFINRVQYGGDEVVKAKAKDGS 240
Query: 238 CIPNLSVAYSSFLFTKSILDAL 259
LS+A + F +L ++
Sbjct: 241 GSATLSMALAGSKFVNEVLQSV 262
>UniRef50_A7TL95 Cluster: Putative uncharacterized protein; n=1;
Vanderwaltozyma polyspora DSM 70294|Rep: Putative
uncharacterized protein - Vanderwaltozyma polyspora DSM
70294
Length = 365
Score = 101 bits (243), Expect = 2e-20
Identities = 71/255 (27%), Positives = 129/255 (50%), Gaps = 19/255 (7%)
Query: 19 QVTVVGATSEVGQVXXXXXXXXXXITKLVVHDNKEFTPGVTLDLSQIPSPSRILGLTGED 78
+V V+GA+ +GQ ++ L ++D + T GV DLS I + S G ++
Sbjct: 3 KVCVLGASGGIGQPLSLLLKLNPYVSDLALYDISDITAGVAKDLSHINTNSDSEGYNKDE 62
Query: 79 TLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPF-VGIVTEP 137
+ L+ S+L+I G+ ++P ++ L N++ I+++ K + P+ + I++ P
Sbjct: 63 DFKNLLEGSELVIVTAGIPRKPGMTRDDLFKINAKIIQNLTVKYAKFAPVHCKLLIISNP 122
Query: 138 INYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCL---YATENNLKA----------- 183
+N LIP+ E ++ +G + ++FGIT +D IRSQ + L++
Sbjct: 123 VNSLIPVVIETLKINGRLNPSQVFGITMLDIIRSQTFLNDLLNDKKLRSGSITSKQFDKT 182
Query: 184 -NDCYVPVIGGHSDKTIVPLLSQAKPTVEMKEKDLEEFTIKLRNCDGMITKAKRG-CIPN 241
N + VIGGHS T+VP+L+ K + ++ +++ K++ I KAK G
Sbjct: 183 LNLNNINVIGGHSAPTMVPILTN-KNLIHQQD-EIDALYKKIKFGGDEIVKAKNGKGSAT 240
Query: 242 LSVAYSSFLFTKSIL 256
LS+AY+ + F IL
Sbjct: 241 LSMAYAGYFFANEIL 255
>UniRef50_P22133 Cluster: Malate dehydrogenase, cytoplasmic; n=3;
Saccharomycetaceae|Rep: Malate dehydrogenase,
cytoplasmic - Saccharomyces cerevisiae (Baker's yeast)
Length = 377
Score = 98.3 bits (234), Expect = 2e-19
Identities = 66/238 (27%), Positives = 121/238 (50%), Gaps = 17/238 (7%)
Query: 46 LVVHD-NKEFTPGVTLDLSQIPSPSRILGLTGEDTLERALKNSDLIIAAGGLSQRPDISE 104
L ++D N+E GVT DLS I +P + + +E L N+ +++ G+ ++P ++
Sbjct: 53 LALYDVNQEAINGVTADLSHIDTPISVSSHSPAGGIENCLHNASIVVIPAGVPRKPGMTR 112
Query: 105 KALLTANSQFIKSIISKLGRSCPIP--FVGIVTEPINYLIP-MTAEIMRNH----GVYDE 157
L N+ I + + C + FV +++ P+N L+P M + I++NH E
Sbjct: 113 DDLFNVNAGIISQLGDSIAECCDLSKVFVLVISNPVNSLVPVMVSNILKNHPQSRNSGIE 172
Query: 158 KKLFGITEIDAIRSQCLYATENNL------KANDC-YVPVIGGHSDKTIVPLLSQAKPTV 210
+++ G+T++D +R+ + E N+ + N VPVIGGHS +TI+PL SQ+
Sbjct: 173 RRIMGVTKLDIVRAS-TFLREINIESGLTPRVNSMPDVPVIGGHSGETIIPLFSQSNFLS 231
Query: 211 EMKEKDLEEFTIKLRNCDGMITKAKRG-CIPNLSVAYSSFLFTKSILDALEGSPAKIH 267
+ E L+ +++ + KAK G LS+A++ + + L G+ +IH
Sbjct: 232 RLNEDQLKYLIHRVQYGGDEVVKAKNGKGSATLSMAHAGYKCVVQFVSLLLGNIEQIH 289
>UniRef50_UPI00015B5ACF Cluster: PREDICTED: similar to
ENSANGP00000020184; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000020184 - Nasonia
vitripennis
Length = 352
Score = 97.9 bits (233), Expect = 3e-19
Identities = 72/316 (22%), Positives = 146/316 (46%), Gaps = 11/316 (3%)
Query: 13 TTTRSYQVTVVGATSEVGQVXXXXXXXXXXITKLVVHDNKEFTPGVTLDLSQIPSPSRIL 72
+ +R+ +V +VGAT + G+ I +L V+D+ T G+ L+LS + S R +
Sbjct: 31 SNSRNLKVAIVGATGQTGRSLALCLKQSALIDELAVYDSHP-TRGLLLELSHMDSRCRTI 89
Query: 73 GLTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVG 132
T DL A G + + +++++ I+S L CP V
Sbjct: 90 VEDEASTTSACNGKRDLERALTGAKIVAITLDGESIREEAEYLEKILSGLLGCCPKALVA 149
Query: 133 IVTEPINYLIPMTAEIMRNHGVYD-EKKLFGITEIDAIRSQCLYATENNLKANDCYVPVI 191
+V+ +N L+PM E+ + G+++ ++FG+ + A R+ L A ++ VPVI
Sbjct: 150 LVSRRVNSLVPMLYELYKRAGLFEASSRIFGVVSLFATRANGLAAETLKIQPELSSVPVI 209
Query: 192 GGHSDKTIVPLLSQAKPTVEMKEKDLEEFTIKLRNCDGMITKAKRGCIPNLSVAYSSFLF 251
GG ++ VPL SQ +P + ++L + +++ + + +L + +++ F
Sbjct: 210 GGGCPRSCVPLFSQTRPCADFTPEELSRLSEAMKSAEAAESS-------SLCLGFAAARF 262
Query: 252 TKSILDALEGSPA-KIHAFVDNNDF-GTSYFSSLVNLDKNGVKEMVRYSEFSKFECDLIE 309
S+ AL P + A+V + Y ++ + L G++ + + S EC +
Sbjct: 263 CISLCKALRAEPGLRECAYVRSCLVPELKYLAAPLELGPTGLQRELGVARISNAECQQLY 322
Query: 310 KSLQQLRKDVSKGRKI 325
+L ++++D+ G +
Sbjct: 323 LALPKIQRDIRLGESL 338
>UniRef50_UPI0000D55CD8 Cluster: PREDICTED: similar to Malate
DeHydrogenase family member (mdh-1); n=1; Tribolium
castaneum|Rep: PREDICTED: similar to Malate
DeHydrogenase family member (mdh-1) - Tribolium
castaneum
Length = 374
Score = 95.5 bits (227), Expect = 2e-18
Identities = 76/292 (26%), Positives = 132/292 (45%), Gaps = 9/292 (3%)
Query: 6 RIISSLFTTTRSYQ--VTVVGATSEVGQVXXXXXXXXXXITKLVVHDNKEFTPGVTLDLS 63
R SSL +T + VT++ S VG I +L + D + T DL+
Sbjct: 15 RFSSSLCPSTAPIKPIVTLLDTLSSVGSNLALLLKQNLDIYELRLFDEENNTNAFACDLN 74
Query: 64 QIPSPSRILGLTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLG 123
+I + +++ + + +L+ A+ + ++I+ GG ++P S++ L N ++++ L
Sbjct: 75 EIDTRTKLKSFSCK-SLKNAIVGAHVVISTGGCQEKPGSSQRELFDKNLDNVRNVAMFLA 133
Query: 124 RSCPIPFVGIVTEPINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKA 183
P I P+ L+PM +E + YD +K+ G+ + ++ + A N
Sbjct: 134 EFNPEAIYCIAKPPVEALVPMVSEEYKKAETYDPRKIIGVATVASMIANTFIAEHTNQNP 193
Query: 184 NDCYVPVIGGHSDKTIVPLLSQAKPTVEMKEKDLEEFTIKLRNCDGMITKAKRGCIPNLS 243
D P+IGG S KT +P+LSQ KP V DL + ++ G T +G + S
Sbjct: 194 ADVLCPIIGGLSPKTTIPVLSQTKPNVPF-NPDLYK-KLQEAVAHGEETLLCKGAMFCYS 251
Query: 244 VAYSSFLFTKSILDALEGSPAKIH-AFV-DNNDFG--TSYFSSLVNLDKNGV 291
A + F ++ AL+G + AFV G Y +S+V L GV
Sbjct: 252 KAVAISRFIHLVVKALKGEKHCVESAFVAQTGHIGEFLPYMTSIVKLGPQGV 303
>UniRef50_A7TSF5 Cluster: Putative uncharacterized protein; n=1;
Vanderwaltozyma polyspora DSM 70294|Rep: Putative
uncharacterized protein - Vanderwaltozyma polyspora DSM
70294
Length = 387
Score = 95.5 bits (227), Expect = 2e-18
Identities = 87/324 (26%), Positives = 150/324 (46%), Gaps = 28/324 (8%)
Query: 13 TTTRSYQV--TVVGATSEVGQVXXXXXXXXXXITK-----LVVHD-NKEFTPGVTLDLSQ 64
T ++S QV TV+GA +GQ L + D N + GV DLS
Sbjct: 34 TNSKSNQVKITVIGAAGGIGQSLSLLLRTSLQNNNDNQLHLALFDVNMKVLNGVHADLSH 93
Query: 65 IPSPSRILGLTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGR 124
+ + + L+ D L +L +S+L+I G+ ++P ++ L N+ IK I +L
Sbjct: 94 VNTNMK---LSLHDNLRDSLVDSNLVIIPAGVPRKPGMTRDDLFNINAGIIKGIAQELNT 150
Query: 125 SCPIPFVGIVTEPINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCL---YATENNL 181
PFV +++ P+N L+P+ ++ + VY + FGITE+D +R+ + +
Sbjct: 151 IDSTPFVLLISNPVNSLLPVLQSVLND--VY-LGRCFGITELDLVRASTFVNGFMDNSAS 207
Query: 182 KANDC-YVPVIGGHSDKTIVPLLSQAK------PTVEMKEKD--LEEFTIKLRNCDGMIT 232
+N+ YVPVIGGHS TI+P+LS ++ D +++ +++ +
Sbjct: 208 SSNEMPYVPVIGGHSGDTILPVLSNCSFNNSTFSAYDLISDDVAIKKLVHRIQYGGDEVV 267
Query: 233 KAKRGC-IPNLSVAYSSFLFTKSILDALEGSPAKIHAFVDNNDFGTSYFSSLVNLDKNGV 291
+AK G LS+AYS+FL K + L + I + S LV+ + V
Sbjct: 268 QAKDGMGSATLSMAYSAFLVAKKFVQLLTNQVSSIDGIFYIPLTTKDWNSPLVD-NAQSV 326
Query: 292 KEMVRYSEFSKFECDLIEKSLQQL 315
+V+ F +C + K + Q+
Sbjct: 327 LPLVQNVPFFSIKCTVNSKGISQI 350
>UniRef50_Q6CP51 Cluster: Similar to sp|P22133 Saccharomyces
cerevisiae YOL126c MDH2 malate dehydrogenase; n=1;
Kluyveromyces lactis|Rep: Similar to sp|P22133
Saccharomyces cerevisiae YOL126c MDH2 malate
dehydrogenase - Kluyveromyces lactis (Yeast) (Candida
sphaerica)
Length = 404
Score = 92.3 bits (219), Expect = 2e-17
Identities = 69/242 (28%), Positives = 121/242 (50%), Gaps = 16/242 (6%)
Query: 45 KLVVHD-NKEFTPGVTLDLSQIPSPSRILGLTGEDT---LERALKNSDLIIAAGGLSQRP 100
+L ++D NK+ G DLS I +P +D+ + + L N+ ++I G+ ++P
Sbjct: 83 RLSLYDVNKDAIVGTAADLSHIDTPITTTAHYPDDSNGGIGQCLSNASVVIIPAGVPRKP 142
Query: 101 DISEKALLTANSQFIKSIISKLGRSCPIPFVGI--VTEPINYLIPM-TAEIMR---NHGV 154
+S L+ N++ IKS+ + + C + V + ++ PIN L+P+ T ++R N
Sbjct: 143 GMSRDDLIGVNAKIIKSLGEDIAKYCDLNKVHVLVISNPINSLVPLLTNTLIRSDANGNS 202
Query: 155 YDEKKLFGITEIDAIRSQCLYATENNLKANDC-YVPVIGGHSDKTIVPLLSQAKPTVE-- 211
E +++GIT++D +RS N K+N +PVIGGHS TI+P+ S + E
Sbjct: 203 NIESRVYGITQLDLVRSSTFVQQLNGFKSNTSPVIPVIGGHSGDTIIPVFSTLERDPEYA 262
Query: 212 -MKEKDLE-EFTIKLRNCDGMITKAKRG-CIPNLSVAYSSFLFTKSILDALEGSPAKIHA 268
+ + + + +++ I KAK G LS+AY+ F +D L G+ I
Sbjct: 263 NLLDNGMRLKMVHRVQYGGDEIVKAKNGNGSATLSMAYAGFKIAAKFIDLLVGNTDTIDD 322
Query: 269 FV 270
V
Sbjct: 323 IV 324
>UniRef50_Q75AT4 Cluster: ADL164Cp; n=2; Saccharomycetales|Rep:
ADL164Cp - Ashbya gossypii (Yeast) (Eremothecium
gossypii)
Length = 381
Score = 90.6 bits (215), Expect = 5e-17
Identities = 55/225 (24%), Positives = 116/225 (51%), Gaps = 15/225 (6%)
Query: 57 GVTLDLSQIPSPSRIL-----GLTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTAN 111
GV DLS + +P + E+ L AL + +++ G+ ++P ++ L+ N
Sbjct: 72 GVAADLSHVNTPVEVSHHVPSSREDEEALREALTGASVVVIPAGVPRKPGMTRDDLININ 131
Query: 112 SQFIKSIISKLGRSCPIP--FVGIVTEPINYLIP-MTAEIMRNHGVYD------EKKLFG 162
+ IK++ + +C + FV +++ P+N L+P M +++R+ E+++FG
Sbjct: 132 AGIIKTLAKGIAGACDLEKVFVLVISNPVNSLVPVMVRQLIRHAEAKQAPHAGVERRVFG 191
Query: 163 ITEIDAIRSQCLYATENNLKANDCYVPVIGGHSDKTIVPLLSQAKPTVEMKEKDLEEFTI 222
+T++D +R+ + L VPVIGGHS +TI+PL + ++ + ++ T
Sbjct: 192 VTQLDMVRASAFVRSLGELGNEVPSVPVIGGHSGETILPLFGPVQQRLQFSLEQRKKLTH 251
Query: 223 KLRNCDGMITKAKRGC-IPNLSVAYSSFLFTKSILDALEGSPAKI 266
+++ I AK+G LS+AY++++ + + + G+ ++I
Sbjct: 252 RVQYGGDEIVAAKKGAGSATLSMAYAAYVVAERFTNLVLGNVSEI 296
>UniRef50_UPI00015B4591 Cluster: PREDICTED: similar to mitochondrial
malate dehydrogenase; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to mitochondrial malate dehydrogenase
- Nasonia vitripennis
Length = 299
Score = 85.8 bits (203), Expect = 1e-15
Identities = 66/286 (23%), Positives = 129/286 (45%), Gaps = 9/286 (3%)
Query: 45 KLVVHDNKEFTPGVTLDLSQIPSPSRILGLTGEDTLERALKNSDLIIAAGGLSQRPDISE 104
+L+ DN +P D+ I + + I L+ L+N+D++
Sbjct: 13 RLIDTDNSLMSP--VCDMRHIDTSTTIRHFRKNSILD-GLRNTDIVALMDETDFMMGNKG 69
Query: 105 KALLTANSQ-FIKSIISKLGRSCPIPFVGIVTEPINYLIPMTAEIMRNHGVYDEKKLFGI 163
+ NS ++KS+ + CP V + T P+ +P+ +EI + G +D ++FG
Sbjct: 70 PFMQFVNSSNYVKSVAECMINVCPKALVAVFTHPVTATLPLVSEIYKYSGDWDPNRIFGS 129
Query: 164 TEIDAIRSQCLYATENNLKANDCYVPVIGGHSDKTIVPLLSQAKPTVEMKEKDLEEFTIK 223
++++R + AT +L + VP+ GG T+VPLLS+A+P E++ +
Sbjct: 130 AALESMRISAMTATLLDLNPSFISVPIAGGIDSLTVVPLLSRARPFNSFTEENECLLIHQ 189
Query: 224 LRNCDGMITKAK-RGCIPNLSVAYSSFLFTKSILDALEGSPAKIHAFVDNNDF--GTSYF 280
LR+ D + + + +G P LS ++ F ++++ ++ I + +D Y
Sbjct: 190 LRSADMKLFETETKG--PTLSSGMAAAKFISTLINGMKKQSISITSAYVRSDVLPSCQYM 247
Query: 281 SSLVNLDKNGVKEMVRYSEFSKFECDLIEKSLQQLRKDVSKGRKIL 326
+S + NGV++ + S E +I ++ + K V K L
Sbjct: 248 TSEIQFGPNGVQQNFGLPKVSPTEISMIGQAAPVINKIVKSAIKFL 293
>UniRef50_Q3J7E7 Cluster: Malate dehydrogenase; n=5;
Gammaproteobacteria|Rep: Malate dehydrogenase -
Nitrosococcus oceani (strain ATCC 19707 / NCIMB 11848)
Length = 311
Score = 70.5 bits (165), Expect = 5e-11
Identities = 56/188 (29%), Positives = 89/188 (47%), Gaps = 10/188 (5%)
Query: 19 QVTVVGATSEVGQVXXXXXXXXXXITKLVVHDNKE-FTPGVTLDLSQ-IPSPSRILGLTG 76
++T+VGA VG+ +LV+ D +E G LD+ Q P +TG
Sbjct: 5 KITIVGA-GRVGEATAQFLVKNELCRELVLLDAQEGVAQGAALDIQQSAPLFDFDARVTG 63
Query: 77 EDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTE 136
E + +SDL++ G ++P +S +L +N I I++ + R P V IVT
Sbjct: 64 STNYE-LIADSDLVVITAGKPRKPGMSRSDVLDSNLPIITDIMNNVMRFAPQSLVMIVTN 122
Query: 137 PINYLIPMTAEIMRNHGVYDEKKLFGITEI-DAIRSQCLYATENNLKANDCYVPVIGGHS 195
P++ L T R+ G +D ++FG + D+ R A E L D V+GGH
Sbjct: 123 PVDVL---TYHAWRHCG-WDRARVFGQAGVLDSARMASFIAGETGLSVKDISAMVLGGHG 178
Query: 196 DKTIVPLL 203
D T++PL+
Sbjct: 179 D-TMLPLI 185
>UniRef50_UPI0000D56DC5 Cluster: PREDICTED: similar to Malate
dehydrogenase, mitochondrial precursor; n=1; Tribolium
castaneum|Rep: PREDICTED: similar to Malate
dehydrogenase, mitochondrial precursor - Tribolium
castaneum
Length = 349
Score = 68.5 bits (160), Expect = 2e-10
Identities = 61/300 (20%), Positives = 121/300 (40%), Gaps = 13/300 (4%)
Query: 19 QVTVVGATSEVGQVXXXXXXXXXXITKLVVHDNKEFTPGVTLDLSQIPSPSRILGLTGED 78
QV ++GA + +GQ I+ L + + + LD + + R+ D
Sbjct: 23 QVCILGADTLLGQSLAFLIKQNPAISGLHLQGTSK-VESMALDFNHFDTRCRVHSYYDMD 81
Query: 79 TLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPI 138
++ +++K +D+++ G + +S L+ A + + + P + + PI
Sbjct: 82 SVSKSVKCADIVVMLGLNTSTSKMSIPKLVMAEGVRVAKLAETCAKYAPKAVIVVAVTPI 141
Query: 139 NYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIGGHSDKT 198
+ +P+ AE+ + Y +L G + +++ + L +VP++GG
Sbjct: 142 SVTLPIVAEVYKQSDWYHPGRLLGSAALAEVKANAIAGHYQTLDPQMVHVPIVGGPDLDC 201
Query: 199 IVPLLSQAKPTVEMKEKDLEEFTIKLRNCDGMITKAKRGCIPNLSVAYSSFLFTKSILDA 258
+PL SQ +P V + +KD ++ + R K P +S A I
Sbjct: 202 AIPLFSQTQP-VGIAQKDTDKLVEEFR---------KEIPQPAMSHAVGLNRMITGIATG 251
Query: 259 LEGS-PAKIHAFVDNNDFGT-SYFSSLVNLDKNGVKEMVRYSEFSKFECDLIEKSLQQLR 316
+ G A + AFV N T Y +V + K G+ + + E E++ QL+
Sbjct: 252 INGDYNANVLAFVRTNIIKTCRYLVCIVKMGKMGILHNYGLQKLRRNELITFEETCLQLK 311
>UniRef50_O67655 Cluster: Malate dehydrogenase 1; n=3; Bacteria|Rep:
Malate dehydrogenase 1 - Aquifex aeolicus
Length = 335
Score = 66.1 bits (154), Expect = 1e-09
Identities = 72/299 (24%), Positives = 139/299 (46%), Gaps = 33/299 (11%)
Query: 50 DNKEFTP--GVTLDLSQIPSP----SRILG--LTGEDTLERALKNSDLIIAAGGLSQRPD 101
+ K F P G LD+ Q+ + +R+ G +T E L+ SD+++ G +RP
Sbjct: 41 EEKVFEPVKGKALDMKQMLAAMDIDARVEGYTVTPEGEGYEPLEGSDIVVITAGFPRRPG 100
Query: 102 ISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPINYLIPMTAEIMRNHGVYDEKKLF 161
+S + LL AN + I I ++ R P V +VT P++ + + +++ + + ++
Sbjct: 101 MSREDLLEANIRIISVIADRIKRYAPDAIVIVVTNPVDVMTYVAYKLLN----FPKNRVM 156
Query: 162 GITEI-DAIRSQCLYATENNLKANDCYVPVIGGHSDKTIVPLLSQAK----PTVEMKEKD 216
G+ + D+ R + + E + D + VIGGH D+ +VPL+S + P ++ K+
Sbjct: 157 GMAGVLDSARFKTFISEELMVSPKDIHAYVIGGHGDE-MVPLISISNVGGIPLKDLLPKE 215
Query: 217 -LEEFTIKLRNCDGMITKAKRGCIPNLSVAYSSFLFTKSILDALEGSPAKI---HAFVDN 272
LE+ + R G I + S Y+ +++AL + +I ++D
Sbjct: 216 KLEKIIERTRFGGGEIVN-----LMGTSAYYAPAAAIVDMIEALVQNSKRILPCSVYLDG 270
Query: 273 ND---FGTSYF--SSLVNLDKNGVKEMVRYSEFSKFECDLIEKSLQQLRKDVSKGRKIL 326
+G F V L NGV+E+++ + E ++ +S++ ++K V IL
Sbjct: 271 EAGEYYGVQGFCVGVPVKLGSNGVEEIIKVPMIEE-EREMWRRSVESVKKTVEVAEGIL 328
>UniRef50_A2SSY4 Cluster: L-lactate dehydrogenase; n=3;
Methanomicrobiales|Rep: L-lactate dehydrogenase -
Methanocorpusculum labreanum (strain ATCC 43576 / DSM
4855 / Z)
Length = 319
Score = 64.5 bits (150), Expect = 4e-09
Identities = 43/190 (22%), Positives = 92/190 (48%), Gaps = 9/190 (4%)
Query: 19 QVTVVGATSEVGQVXXXXXXXXXXITKLVVHD---NKEFTPGVTLDLSQIPSPSRILGLT 75
+VT++GAT +VG + ++ ++ N+++ G+ D+ +
Sbjct: 3 KVTIIGATGQVGSYVAHAVSQFPHVQEMCLYGRPGNEQYLDGLAHDMMDSFAARGTNTRV 62
Query: 76 GEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVT 135
T + L+ SD+I+ G+ ++ + L N++ +K ++GR P + +VT
Sbjct: 63 TFGTTPKELRGSDIIVLTSGVPRKATQTRLDLALENARIVKVFAEQVGRMAPEAILLVVT 122
Query: 136 EPINYLIPMTAEIMRNHGVYDEKKLFGI-TEIDAIRSQCLYATENNLKANDCYVPVIGGH 194
P++ MT ++ G+ ++FG+ T +D++R + A N+ ++ + +IG H
Sbjct: 123 NPVDI---MTTVALKYSGMMPH-RVFGLGTHLDSMRLKACLAEFFNVHVSEIHTRIIGEH 178
Query: 195 SDKTIVPLLS 204
D T+VP+ S
Sbjct: 179 GD-TMVPMWS 187
>UniRef50_UPI0000DB6C4F Cluster: PREDICTED: similar to Malate
DeHydrogenase family member (mdh-1); n=1; Apis
mellifera|Rep: PREDICTED: similar to Malate
DeHydrogenase family member (mdh-1) - Apis mellifera
Length = 221
Score = 62.1 bits (144), Expect = 2e-08
Identities = 48/196 (24%), Positives = 84/196 (42%), Gaps = 3/196 (1%)
Query: 131 VGIVTEPINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPV 190
V + P+ +P +EI + G +D ++ G T +D +R + L A +L VP+
Sbjct: 14 VAVFVRPVTATLPTVSEIYKLAGWWDPDRIIGSTALDRMRMEALTANLLDLNPAFLSVPL 73
Query: 191 IGGHSDKTIVPLLSQAKPTVEMKEKDLEEFTIKLRNCDGMITKAKRGCIPNLSVAYSSFL 250
+GG TIVPLLS A P + LR+ D + + P LS ++
Sbjct: 74 VGGADLNTIVPLLSCATPINRFTNAQQDMLLQSLRSADKEMANIELKS-PTLSDGAAAAK 132
Query: 251 FTKSILDALEG-SPAKIHAFVDNNDFGT-SYFSSLVNLDKNGVKEMVRYSEFSKFECDLI 308
++ L G A+V +N YF+S + G+++ + S E L+
Sbjct: 133 LILALAGGLSGFKNITSSAYVRSNVLPVCRYFTSELQFGPGGIQKNFGLPKMSSTEIMLV 192
Query: 309 EKSLQQLRKDVSKGRK 324
E+++ + K + K
Sbjct: 193 EQAIPCINKCIGMATK 208
>UniRef50_Q64P62 Cluster: Malate dehydrogenase; n=28;
Bacteroidetes|Rep: Malate dehydrogenase - Bacteroides
fragilis
Length = 313
Score = 60.5 bits (140), Expect = 6e-08
Identities = 48/189 (25%), Positives = 91/189 (48%), Gaps = 12/189 (6%)
Query: 19 QVTVVGATSEVGQVXXXXXXXXXXITKLVVHDNKE-FTPGVTLDLSQIPS----PSRILG 73
+VTVVGA VG ++V+ D KE + G +D+ Q + I+G
Sbjct: 3 KVTVVGA-GNVGATCANVLAFNEVADEVVMLDVKEGVSEGKAMDMMQTAQLLGFDTTIVG 61
Query: 74 LTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGI 133
T D + A NSD+++ G+ ++P ++ + L+ N+ +KS+ L + P + +
Sbjct: 62 CTN-DYAQTA--NSDVVVITSGIPRKPGMTREELIGVNAGIVKSVAENLLKYSPNAIIVV 118
Query: 134 VTEPINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIGG 193
++ P++ MT +++ G+ + + +D+ R + + AN+ VIGG
Sbjct: 119 ISNPMD---TMTYLALKSLGLPKNRVIGMGGALDSSRFKYFLSQALGCNANEVEGMVIGG 175
Query: 194 HSDKTIVPL 202
H D T++PL
Sbjct: 176 HGDTTMIPL 184
>UniRef50_P16115 Cluster: L-lactate dehydrogenase; n=4;
Thermotogaceae|Rep: L-lactate dehydrogenase - Thermotoga
maritima
Length = 319
Score = 60.5 bits (140), Expect = 6e-08
Identities = 54/190 (28%), Positives = 87/190 (45%), Gaps = 10/190 (5%)
Query: 19 QVTVVGATSEVGQVXXXXXXXXXXITKLVVHD-NKEFTPGVTLDLSQIPSPSRILGLTGE 77
++ +VG VG ++V+ D +K+ G LDL +R +
Sbjct: 2 KIGIVGL-GRVGSSTAFALLMKGFAREMVLIDVDKKRAEGDALDLIHGTPFTRRANIYAG 60
Query: 78 DTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEP 137
D + LK SD++I A G+ Q+P + LL N++ +K I + + P V +VT P
Sbjct: 61 DYAD--LKGSDVVIVAAGVPQKPGETRLQLLGRNARVMKEIARNVSKYAPDSIVIVVTNP 118
Query: 138 INYLIPMTAEIMRNHGVYDEKKLFGI-TEIDAIRSQCLYATENNLKANDCYVPVIGGHSD 196
++ L T ++ G+ D +K+FG T +D R + L A +V VIG H D
Sbjct: 119 VDVL---TYFFLKESGM-DPRKVFGSGTVLDTARLRTLIAQHCGFSPRSVHVYVIGEHGD 174
Query: 197 KTIVPLLSQA 206
VP+ S A
Sbjct: 175 SE-VPVWSGA 183
>UniRef50_A7I2F1 Cluster: Malate dehydrogenase; n=1; Campylobacter
hominis ATCC BAA-381|Rep: Malate dehydrogenase -
Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 /
NCTC 13146 /CH001A)
Length = 297
Score = 59.3 bits (137), Expect = 1e-07
Identities = 66/305 (21%), Positives = 131/305 (42%), Gaps = 18/305 (5%)
Query: 19 QVTVVGATSEVGQVXXXXXXXXXXITKLVVHDN-KEFTPGVTLDLSQIPSP-SRILGLTG 76
+++++GA + + I+++ + D + LDLS + S ++ ++G
Sbjct: 2 KISIIGAGNIGSNIVSQLLCKDFEISQIALIDIFGDLAKARALDLSHLASVYNKKTEISG 61
Query: 77 EDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTE 136
E LKNSD+++ G +++ S LL N++ I S + + P + ++T
Sbjct: 62 SSD-ETLLKNSDIVVITAGKTRQAGQSRADLLNDNAKIISSCAKNVAKYAPEAIIILITN 120
Query: 137 PINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIGGHSD 196
P++ L + + G EK + E+D+ R + A N+ D V+G H+D
Sbjct: 121 PVDTLAFVA---YKASGFKKEKIIAMAGELDSARLRYEIAKSENVNVTDIKASVVGAHND 177
Query: 197 KTIVPLLSQAKPTVEMKEKDLEEFTIKLRNCDGMITKAKRGCIPNLSVAYSSFLFTKSIL 256
+ + K + K ++L N IT + S ++ + ++
Sbjct: 178 EMQILEDEIYKFGKKFKPQNLSLIKENTINSGSKIT-----ALQKTSSFFAPAACSVKMI 232
Query: 257 DAL--EGSPAKIHAFVDNNDFGTSYFSSLVNLDKNGVKEMV--RYSEFSKFECDLIEKSL 312
DA+ + + I + +D N+ F V L+KNGV E++ Y E +K + I+ +
Sbjct: 233 DAIINDKNEILICSVLDENEIPIGRF---VRLNKNGVAEILPFDYGEKTKSGLENIKGQI 289
Query: 313 QQLRK 317
L K
Sbjct: 290 LNLNK 294
>UniRef50_A7U552 Cluster: Mitochondrial malate-dehydrogenase; n=2;
Toxoplasma gondii|Rep: Mitochondrial
malate-dehydrogenase - Toxoplasma gondii
Length = 470
Score = 59.3 bits (137), Expect = 1e-07
Identities = 41/153 (26%), Positives = 77/153 (50%), Gaps = 8/153 (5%)
Query: 52 KEFTPGVTLDLSQIPSPSRI-LGLTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTA 110
++ G LDL Q+ S + + G + LK++D+II G+ ++P +S LL
Sbjct: 191 QDLPQGKCLDLYQLTPISGVDVRFEGSNDYS-VLKDADVIIVTAGVPRKPGMSRDDLLAI 249
Query: 111 NSQFIKSIISKLGRSCPIPFVGIVTEPINYLIPMTAEIMRNHGVYDEKKLFGITEI-DAI 169
N++ + + + + CP FV +T P++ ++ I+R K+ G+ + D+
Sbjct: 250 NAKIMGQVGEAIKQYCPNAFVICITNPLDVMV----YILREKCGLPPHKVCGMAGVLDSA 305
Query: 170 RSQCLYATENNLKANDCYVPVIGGHSDKTIVPL 202
R + + N+ +D + V+GGH D T+VPL
Sbjct: 306 RLRTFLSERLNVSVDDIHALVMGGHGD-TMVPL 337
>UniRef50_UPI00005A0834 Cluster: PREDICTED: similar to Malate
dehydrogenase, mitochondrial precursor; n=1; Canis lupus
familiaris|Rep: PREDICTED: similar to Malate
dehydrogenase, mitochondrial precursor - Canis
familiaris
Length = 245
Score = 58.0 bits (134), Expect = 3e-07
Identities = 21/82 (25%), Positives = 43/82 (52%)
Query: 98 QRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPINYLIPMTAEIMRNHGVYDE 157
++P ++ L N+ + + + + CP + +++ P+N IP+ E+ + HG YD
Sbjct: 62 RKPGMTRDDLFNTNASVVATPTAACAQHCPEAMICVISNPVNSTIPIATEVFKKHGAYDP 121
Query: 158 KKLFGITEIDAIRSQCLYATEN 179
K+F +T +D +R+ A N
Sbjct: 122 NKIFRVTTLDIVRANTFIAELN 143
Score = 34.3 bits (75), Expect = 4.4
Identities = 21/78 (26%), Positives = 43/78 (55%), Gaps = 3/78 (3%)
Query: 236 RGCIPNLSVAYSSFLFTKSILDALEGSPAKIH-AFVDNNDFGTSYFSSLVNLDKNGVKEM 294
R C P A + F+F S++DA+ G + +FV + + +YFS+ + L + G+++
Sbjct: 168 RLCHPVHGRAGAQFVF--SLVDAMNGKEGDVECSFVKSQEADCAYFSTPLLLGEKGIEKN 225
Query: 295 VRYSEFSKFECDLIEKSL 312
+ + S FE +I +++
Sbjct: 226 LGIGKISPFEEKMIAEAI 243
>UniRef50_Q7NHJ3 Cluster: Malate dehydrogenase; n=13; cellular
organisms|Rep: Malate dehydrogenase - Gloeobacter
violaceus
Length = 325
Score = 56.8 bits (131), Expect = 7e-07
Identities = 50/189 (26%), Positives = 84/189 (44%), Gaps = 9/189 (4%)
Query: 16 RSYQVTVVGATSEVGQVXXXXXXXXXXITKLVVHDNKEFTP-GVTLDLSQIPS-PSRILG 73
R +V+++GA VG + +V+ D E P G+TLDL +
Sbjct: 7 RESKVSILGA-GNVGSALAQRLIQGN-VADVVLLDIVEGRPQGITLDLLEACGVEGHTCR 64
Query: 74 LTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGI 133
+TG + + SD+++ A G +++P +S LL N++ + + K P V +
Sbjct: 65 ITGTNDYAQTA-GSDVLVVAAGFARQPGMSRDDLLLTNTRIVFEVTQKAVAHSPEATVVV 123
Query: 134 VTEPINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIGG 193
VT P++ M+ R G+ E+ + +DA R + A E D V+GG
Sbjct: 124 VTNPLD---AMSHVAWRASGLVPERVMGMAGVLDAARFETFIAWELGFSVRDIRAMVLGG 180
Query: 194 HSDKTIVPL 202
H D +VPL
Sbjct: 181 HGD-LMVPL 188
>UniRef50_A7GYI6 Cluster: Lactate/malate dehydrogenase, NAD binding
domain protein; n=2; Campylobacter|Rep: Lactate/malate
dehydrogenase, NAD binding domain protein -
Campylobacter curvus 525.92
Length = 297
Score = 55.6 bits (128), Expect = 2e-06
Identities = 32/118 (27%), Positives = 61/118 (51%), Gaps = 5/118 (4%)
Query: 84 LKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPINYLIP 143
++ SD+++ G ++ + + LL N+Q +K + + P V IVT P++
Sbjct: 67 IEASDIVVVTAGSPRKEGQTREDLLLKNAQVVKQTAQNIAKFAPNAIVIIVTNPLDV--- 123
Query: 144 MTAEIMRNHGVYDEKKLFGIT-EIDAIRSQCLYATENNLKANDCYVPVIGGHSDKTIV 200
M ++R G +D ++ G+ E+D+ R + A+ ++ A D V+G H+DK IV
Sbjct: 124 MVWTVLRYSG-FDRSRVIGMAGELDSARCRYEIASLKDISAKDVSAKVLGAHNDKMIV 180
>UniRef50_P19869 Cluster: L-lactate dehydrogenase 2; n=17;
Bacteria|Rep: L-lactate dehydrogenase 2 -
Bifidobacterium longum
Length = 320
Score = 55.2 bits (127), Expect = 2e-06
Identities = 45/196 (22%), Positives = 85/196 (43%), Gaps = 9/196 (4%)
Query: 13 TTTRSYQVTVVGATSEVGQVXXXXXXXXXXITKLVVHD-NKEFTPGVTLDLSQIPSPSRI 71
TT + ++ V+GA + VG ++V+ D KE LD+ S
Sbjct: 4 TTVKPTKLAVIGAGA-VGSTLAFAAAQRGIAREIVLEDIAKERVEAEVLDMQHGSSFYPT 62
Query: 72 LGLTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFV 131
+ + G D E +++D+++ G Q+P S L+ A +K+I+ L + P
Sbjct: 63 VSIDGSDDPE-ICRDADMVVITAGPRQKPGQSRLELVGATVNILKAIMPNLVKVAPNAIY 121
Query: 132 GIVTEPINYLIPMTAEIMRNHGVYDEKKLFGI-TEIDAIRSQCLYATENNLKANDCYVPV 190
++T P++ + + + E ++FG T +D+ R + L A + + + + +
Sbjct: 122 MLITNPVD----IATHVAQKLTGLPENQIFGSGTNLDSARLRFLIAQQTGVNVKNVHAYI 177
Query: 191 IGGHSDKTIVPLLSQA 206
G H D VPL A
Sbjct: 178 AGEHGDSE-VPLWESA 192
>UniRef50_A3BMG8 Cluster: Putative uncharacterized protein; n=3;
Oryza sativa|Rep: Putative uncharacterized protein -
Oryza sativa subsp. japonica (Rice)
Length = 405
Score = 54.8 bits (126), Expect = 3e-06
Identities = 27/123 (21%), Positives = 57/123 (46%), Gaps = 1/123 (0%)
Query: 5 RRIISSLFTTTRSYQVTVVGATSEVGQVXXXXXXXXXXITKLVVHDNKEFTPGVTLDLSQ 64
RR + + Y+V ++GA +GQ ++ L ++D GVT DL
Sbjct: 65 RRAGNRVVAQAGGYKVAILGAAGGIGQPLSLLVKMSPLVSALHLYDIAN-VDGVTADLGH 123
Query: 65 IPSPSRILGLTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGR 124
+P+++ G TG++ L L D+++ G+ ++P ++ L N+ ++ ++ +
Sbjct: 124 CNTPAKVAGFTGKEELAGCLAGVDVVVIPAGVPRKPGMTRDDLFGINAGIVRELVEAVAD 183
Query: 125 SCP 127
P
Sbjct: 184 HAP 186
Score = 36.7 bits (81), Expect = 0.83
Identities = 31/125 (24%), Positives = 61/125 (48%), Gaps = 11/125 (8%)
Query: 208 PTVEMKEKDLEEFTIKLRNCDGMITKAKR---GCIPNLSVAYSSFLFTKSILDALEGSPA 264
P ++++E T +++N + +AK G LS+AY++ F ++ L L+G A
Sbjct: 268 PKTAFTDEEVEALTRRIQNAGTEVVEAKAKAGGGSATLSMAYAAARFLEASLRGLDGD-A 326
Query: 265 KIH--AFVDNNDFGT-SYFSSLVNLDKNGVKEMVRYSE----FSKFECDLIEKSLQQLRK 317
++ ++V +F+ V L ++GV+E+ ++FE +E QL+K
Sbjct: 327 DVYECSYVQCQAVPELPFFACRVKLGRDGVEEVAAAGAELRGLTEFEARALEALKPQLKK 386
Query: 318 DVSKG 322
+ KG
Sbjct: 387 SIDKG 391
>UniRef50_Q8XP62 Cluster: L-lactate dehydrogenase; n=11;
Clostridium|Rep: L-lactate dehydrogenase - Clostridium
perfringens
Length = 317
Score = 54.0 bits (124), Expect = 5e-06
Identities = 45/220 (20%), Positives = 102/220 (46%), Gaps = 13/220 (5%)
Query: 16 RSYQVTVVGATSEVGQVXXXXXXXXXXITKLVVHD-NKEFTPGVTLDLSQIPSPSRILGL 74
++ +++++GA VG +++V+ D NK+ +DL+Q + + + +
Sbjct: 5 KTNKISIIGA-GFVGSTTAFALMQDGLASEIVIVDINKDKAHAEAMDLAQGAAFVKSVDI 63
Query: 75 TGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIV 134
D + K+SD++I G+ +P + ++ N + +SI+ ++ + P + +V
Sbjct: 64 KSGDYADT--KDSDIVIITAGVGPKPGETRLDIINKNLKIFQSIVPEVVKYSPNSILLVV 121
Query: 135 TEPINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIGGH 194
+ P++ L +T ++ G E+ + T +D R + + + ++ A + + +IG H
Sbjct: 122 SNPVDILTYITYKL---SGFPKERVIGSGTVLDTSRLKYMLSEHFDIDARNVHTYIIGEH 178
Query: 195 SDKTIVPLLSQAKPTVEMKEKDLEEFTIKL-RNCDGMITK 233
D I A + ++EE+ + NCDG K
Sbjct: 179 GDSEIT-----AWSLTNIAGANVEEYCKTVCANCDGSFKK 213
>UniRef50_A7I5J9 Cluster: L-lactate dehydrogenase precursor; n=1;
Candidatus Methanoregula boonei 6A8|Rep: L-lactate
dehydrogenase precursor - Methanoregula boonei (strain
6A8)
Length = 332
Score = 53.2 bits (122), Expect = 9e-06
Identities = 43/191 (22%), Positives = 93/191 (48%), Gaps = 11/191 (5%)
Query: 19 QVTVVGATSEVGQVXXXXXXXXXXITKLVVH--DNKE-FTPGVTLDLSQ-IPSPSRILGL 74
+VT++GAT VG + +++++ + +E F G+ D + + + +
Sbjct: 3 KVTIIGATGNVGTFAAYAVSVDPHVHEILLYGREGREAFLKGLAQDFADSFAARGTNIRV 62
Query: 75 TGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIV 134
T +L + + SD+++ G + P + L N++ I + +G P + +V
Sbjct: 63 TWTTSL-KDVAGSDIVVITAGTPRGPGQNRLDLALGNARIIAPMARTIGTIAPDTKIIMV 121
Query: 135 TEPINYLIPMTAEIMRNHGVYDEKKLFGI-TEIDAIRSQCLYATENNLKANDCYVPVIGG 193
T P++ MT ++ G+ ++FG+ T +D++R + L A+ + ++ + +IG
Sbjct: 122 TNPVDV---MTCVALKYSGL-KPNQVFGLGTHLDSMRLKSLIASYFKVHVSEVHTRIIGE 177
Query: 194 HSDKTIVPLLS 204
H D ++VPL S
Sbjct: 178 HGD-SMVPLWS 187
>UniRef50_UPI00015BB1FC Cluster: malate dehydrogenase (NAD); n=1;
Ignicoccus hospitalis KIN4/I|Rep: malate dehydrogenase
(NAD) - Ignicoccus hospitalis KIN4/I
Length = 311
Score = 51.6 bits (118), Expect = 3e-05
Identities = 53/216 (24%), Positives = 99/216 (45%), Gaps = 20/216 (9%)
Query: 18 YQVTVVGATSEVGQVXXXXXXXXXXITKLVVHDNKE-FTPGVTLDLSQIPSP-SRILGLT 75
Y+V V+G T VG + ++V+ D + GV D+ + R + +
Sbjct: 6 YKVAVIG-TGRVGATFAYTMAIVPGVARMVLVDAVPGLSKGVMEDIKHAAAVFRRSIQVE 64
Query: 76 GEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVT 135
D + + ++N+D I+ G ++ D+S + L N+Q I+ I KL P F ++T
Sbjct: 65 AYDDVSK-VENADAIVITAGKPRKADMSRRDLAKVNAQIIRDIGDKLRDRNPGAFYMVIT 123
Query: 136 EPINYLIPMTAEIMRNHGVYDEKKLFGI-TEIDAIRSQCLYATENN--LKANDCYVPVIG 192
P++ + + ++++ N G + G T +D R + + N + A D Y V+G
Sbjct: 124 NPVDVMTMILSDVIGNKGT-----VIGTGTSLDTYRFRSAVSELLNEPIAAIDGY--VVG 176
Query: 193 GHSDKTIVPLLSQAKPTVEMKEKDLEEFTIKLRNCD 228
H ++ V A TV +K ++E+ IK + D
Sbjct: 177 EHGEEAFV-----AWSTVTVKGVPIDEY-IKEKGLD 206
>UniRef50_Q6VVP7 Cluster: Malate dehydrogenase; n=6; Plasmodium|Rep:
Malate dehydrogenase - Plasmodium falciparum
Length = 313
Score = 50.8 bits (116), Expect = 5e-05
Identities = 42/163 (25%), Positives = 78/163 (47%), Gaps = 15/163 (9%)
Query: 46 LVVHDNKEFTP-GVTLDLSQIPSPSRILGLT----GEDTLERALKNSDLIIAAGGLSQRP 100
L+++D P G LDL S ILG+ G + +E +K++D+I+ G+ ++
Sbjct: 28 LILYDVVPGIPQGKALDLKHF---STILGVNRNILGTNQIED-IKDADIIVITAGVQRKE 83
Query: 101 DISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPINYLIPMTAEIMRNHGVYDEKKL 160
++ + L+ N + +KS+ + C FV V+ P++ ++ + +K+
Sbjct: 84 GMTREDLIGVNGKIMKSVAESVKLHCSKAFVICVSNPLDIMV----NVFHKFSNLPHEKI 139
Query: 161 FGITEI-DAIRSQCLYATENNLKANDCYVPVIGGHSDKTIVPL 202
G+ I D R L A + + A D ++GGH D +VPL
Sbjct: 140 CGMAGILDTSRYCSLIADKLKVSAEDVNAVILGGHGD-LMVPL 181
>UniRef50_Q979N9 Cluster: Malate dehydrogenase; n=4;
Thermoplasmatales|Rep: Malate dehydrogenase -
Thermoplasma volcanium
Length = 325
Score = 50.8 bits (116), Expect = 5e-05
Identities = 31/130 (23%), Positives = 65/130 (50%), Gaps = 6/130 (4%)
Query: 75 TGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIV 134
T + + + ++ SD+I+ G++++P +S + L N + I + + + P + +V
Sbjct: 65 TSDSSNYKNMEGSDVIVVTAGMARKPGMSREDLFDKNVEIIADVSKNIKKYSPDSIIVVV 124
Query: 135 TEPINYLIPMTAEIMRNHGVYDEKKLFGIT-EIDAIRSQCLYATENNLKANDCYVPVIGG 193
+ P + M + + GV D +++ G+ +D+ R + A E ++ D VIGG
Sbjct: 125 SNPADI---MAYALQKISGV-DPQRIMGLGGSLDSSRFRTFLAKELDVSVEDVNAFVIGG 180
Query: 194 HSDKTIVPLL 203
H D +VP +
Sbjct: 181 HGD-DMVPFI 189
>UniRef50_Q9PHY2 Cluster: Probable malate dehydrogenase; n=12;
Campylobacter|Rep: Probable malate dehydrogenase -
Campylobacter jejuni
Length = 300
Score = 50.8 bits (116), Expect = 5e-05
Identities = 65/304 (21%), Positives = 133/304 (43%), Gaps = 23/304 (7%)
Query: 19 QVTVVGATSEVGQVXXXXXXXXXXITKLVVHD-NKEFTPGVTLDLSQ-IPSPSRILGLTG 76
++TV+GA VG ++V+ D N++ L+L+Q I + + + L
Sbjct: 2 KITVIGA-GNVGSSVAYALILREIANEIVLVDINEDLLYAKELELTQSIAALNLNIDLLC 60
Query: 77 EDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTE 136
KNSD+++ + G +++ S + LL N+ + K+ P I+T
Sbjct: 61 TKDYTHT-KNSDIVLFSAGFARKDGQSREELLQLNTSIMLDCAKKIKDFTEDPLFIILTN 119
Query: 137 PINYLIPMTAEIMRNHGVYDEKKLFGITEI-DAIRSQCLYATENNLKANDCYVPVIGGHS 195
P+++L+ + G++ KK+ + + D R + A + N+K + +IG H+
Sbjct: 120 PVDFLL----NTLYESGIFSSKKIIAMAGVLDNARFKYELAKKLNVKMSRVDTRLIGFHN 175
Query: 196 DKTIVPLLSQAKPTVEMKEKDLEEFTIKLRNCDGMITKAKRGCIPNLS-VAYSSFLFTKS 254
D ++ K +K K++ EF + + + + K G + + S++L S
Sbjct: 176 DDMVL-----VKSYASVKNKNISEF-LNEEEFEDLENEVKTGGAKVIKHLKTSAYLAPAS 229
Query: 255 ----ILDALEGSPAKIHAFVDNNDFG--TSYFSSLVNLDKNGVKEMVRYSEFSKFECDLI 308
+L+++ + + + +FG + L GV E+++ + S E D +
Sbjct: 230 ACIRMLESIRSGEFLPMSVILHGEFGVQNKALGVMARLGLEGVIEIMK-MDLSLQEKDKL 288
Query: 309 EKSL 312
EKSL
Sbjct: 289 EKSL 292
>UniRef50_O26290 Cluster: Malate dehydrogenase; n=2;
Methanobacteriaceae|Rep: Malate dehydrogenase -
Methanobacterium thermoautotrophicum
Length = 325
Score = 50.4 bits (115), Expect = 6e-05
Identities = 42/191 (21%), Positives = 84/191 (43%), Gaps = 11/191 (5%)
Query: 19 QVTVVGATSEVGQVXXXXXXXXXXITKLVVHDNKEFTP---GVTLDLSQIPSPSRI-LGL 74
+V+++G+T VG+ + L + KE G LD+S + + + L
Sbjct: 2 KVSIIGSTGRVGRATALCLAEEEAVKTLHLISRKESLEQNLGEVLDMSDALAAKGVSVKL 61
Query: 75 TGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIV 134
+E S +++ G+ + D+ L N + + ++ R P + +V
Sbjct: 62 ENSADIENVY-GSRIVVITAGVPRTADMDRDDLAFKNGRIVADYARQIARFAPDSIILVV 120
Query: 135 TEPINYLIPMTAEIMRNHGVYDEKKLFGI-TEIDAIRSQCLYATENNLKANDCYVPVIGG 193
T P++ MT +R G + ++FG+ +D++R + A N+ ++ + VIG
Sbjct: 121 TNPVDV---MTYVALRYSG-FHPSRVFGLGNHLDSLRLKNYMARHFNVHVSEVHTRVIGQ 176
Query: 194 HSDKTIVPLLS 204
H +VPL+S
Sbjct: 177 HG-PYMVPLIS 186
>UniRef50_Q8YJE7 Cluster: Malate dehydrogenase; n=98; Bacteria|Rep:
Malate dehydrogenase - Brucella melitensis
Length = 320
Score = 50.4 bits (115), Expect = 6e-05
Identities = 41/159 (25%), Positives = 78/159 (49%), Gaps = 7/159 (4%)
Query: 46 LVVHDNKEFTP-GVTLDLSQI-PSPSRILGLTGEDTLERALKNSDLIIAAGGLSQRPDIS 103
+V+ D E TP G LD+++ P TG + A++ +D++I G+ ++P +S
Sbjct: 30 VVLFDIAEGTPQGKGLDIAESSPVDGFDAKFTGANDYA-AIEGADVVIVTAGVPRKPGMS 88
Query: 104 EKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPINYLIPMTAEIMRNHGVYDEKKLFGI 163
LL N + ++ + + + + P FV +T P++ M + + G+ K +
Sbjct: 89 RDDLLGINLKVMEQVGAGIKKYAPEAFVICITNPLD---AMVWALQKFSGLPAHKVVGMA 145
Query: 164 TEIDAIRSQCLYATENNLKANDCYVPVIGGHSDKTIVPL 202
+D+ R + + E N+ D V+GGH D ++VPL
Sbjct: 146 GVLDSARFRYFLSEEFNVSVEDVTAFVLGGHGD-SMVPL 183
>UniRef50_Q5CYZ2 Cluster: Lactate dehydrogenase, adjacent gene
encodes predicted malate dehydrogenase; n=8;
Cryptosporidium|Rep: Lactate dehydrogenase, adjacent
gene encodes predicted malate dehydrogenase -
Cryptosporidium parvum Iowa II
Length = 337
Score = 50.0 bits (114), Expect = 8e-05
Identities = 37/147 (25%), Positives = 66/147 (44%), Gaps = 8/147 (5%)
Query: 58 VTLDLSQIPSPSRILGLTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKS 117
+T + S S+++G D + + SD++I + RP LL N++ + S
Sbjct: 64 ITHSMVMFGSTSKVIGTN--DYAD--ISGSDVVIITASIPGRPKDDRSELLFGNARILDS 119
Query: 118 IISKLGRSCPIPFVGIVTEPINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYAT 177
+ + + CP FV +T P++ M + + G+ K +D+ R + A
Sbjct: 120 VAEGVKKYCPNAFVICITNPLDV---MVSHFQKVSGLPHNKVCGMAGVLDSSRFRTFIAQ 176
Query: 178 ENNLKANDCYVPVIGGHSDKTIVPLLS 204
+ A+D VIGGH D +VP+ S
Sbjct: 177 HFGVNASDVSANVIGGHGD-GMVPVTS 202
>UniRef50_Q5LXE1 Cluster: Malate dehydrogenase; n=115; cellular
organisms|Rep: Malate dehydrogenase - Silicibacter
pomeroyi
Length = 320
Score = 50.0 bits (114), Expect = 8e-05
Identities = 44/158 (27%), Positives = 74/158 (46%), Gaps = 7/158 (4%)
Query: 46 LVVHDNKEFTP-GVTLDLSQI-PSPSRILGLTGEDTLERALKNSDLIIAAGGLSQRPDIS 103
+V+ D E TP G LD+++ PS L G + + +D+ I G+ ++P +S
Sbjct: 30 VVLFDIAEGTPEGKALDIAESGPSEGFDAKLKGTQSYAD-IAGADVCIVTAGVPRKPGMS 88
Query: 104 EKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPINYLIPMTAEIMRNHGVYDEKKLFGI 163
LL N + +KS+ + + P FV +T P++ M + + G+ K
Sbjct: 89 RDDLLGINLKVMKSVGEGIRDNAPDAFVICITNPLD---AMVWALQQFSGLPANKVCGMA 145
Query: 164 TEIDAIRSQCLYATENNLKANDCYVPVIGGHSDKTIVP 201
+D+ R + A E N+ D V+GGH D T+VP
Sbjct: 146 GVLDSARFRHFLAEEFNVSMKDVTAFVLGGHGD-TMVP 182
>UniRef50_Q98PG4 Cluster: L-lactate dehydrogenase; n=1; Mycoplasma
pulmonis|Rep: L-lactate dehydrogenase - Mycoplasma
pulmonis
Length = 315
Score = 50.0 bits (114), Expect = 8e-05
Identities = 42/183 (22%), Positives = 79/183 (43%), Gaps = 5/183 (2%)
Query: 19 QVTVVGATSEVGQVXXXXXXXXXXITKLVVHD-NKEFTPGVTLDLSQIPSPSRILGLTGE 77
+V ++G T VG + V+ D N EF G +D+S + + G
Sbjct: 3 KVVLIG-TGNVGVTVVYTMITKGIDAEYVLIDINTEFAKGHAMDMSDAIALNSTTGSKIR 61
Query: 78 DTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEP 137
K +DL+I A G Q+ + ++ NS+ +K I ++ +S F +++ P
Sbjct: 62 TGTYADAKGADLLIVAAGRPQKQGETRLEMIADNSKIMKDIALEIKKSGFNGFTIVISNP 121
Query: 138 INYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIGGHSDK 197
++ L + ++ EK + T +D R + + + + N + VIG H DK
Sbjct: 122 VDILATVFQKVT---NFPKEKVMSSGTFLDTSRFRKFLSEKTGVPTNSVHGFVIGEHGDK 178
Query: 198 TIV 200
++V
Sbjct: 179 SVV 181
>UniRef50_O51114 Cluster: L-lactate dehydrogenase; n=4; Borrelia
burgdorferi group|Rep: L-lactate dehydrogenase -
Borrelia burgdorferi (Lyme disease spirochete)
Length = 316
Score = 50.0 bits (114), Expect = 8e-05
Identities = 76/326 (23%), Positives = 138/326 (42%), Gaps = 35/326 (10%)
Query: 16 RSYQVTVVGATSEVGQVXXXXXXXXXXITKLVVHD-NKEFTPGVTLDLS--QIPSPSRIL 72
+S +V ++GA + +LV+ D N+ G +DL+ Q+ I
Sbjct: 3 KSNKVVLIGAGGVGSSFAYALTIDNSLVHELVIIDVNENKAKGEVMDLNHGQMFLKKNIN 62
Query: 73 GLTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVG 132
L G + N+D+++ GL+Q+P + L+ NS+ K II+ + S F G
Sbjct: 63 VLFGT---YKDCANADIVVITAGLNQKPGETRLDLVDKNSKIFKDIITNVVSS---GFDG 116
Query: 133 IVTEPINYLIPMTAEIMRNHGVYDEKKLFGI-TEIDAIRSQCLYATENNLKANDCYVPVI 191
I N + MT M+ + + K+ G T +D R + + N+ + + ++
Sbjct: 117 IFVVASNPVDIMTYVTMK-YSKFPIHKVIGTGTILDTSRLRYFLSDHFNVNTQNIHSYIM 175
Query: 192 GGHSD---------KTIVPLLSQAKPTVEMKEKDLEEFTIKLRNCDGMITKAKRGCIPNL 242
G H D K + LS+ ++ E +L+E K+ N + K K
Sbjct: 176 GEHGDSSFATWDETKIAMKPLSEYLAEGKITELELDEIHKKVVNAAYEVIKLKG------ 229
Query: 243 SVAYSSFLFTKSILDALEGSP---AKIHAFVDNNDFG----TSYFSSLVNLDKNGVKEMV 295
+ Y+ L K+I++A+ G I +++ N +G Y + + K GVKE++
Sbjct: 230 ATYYAIGLGIKNIVNAIIGDQNVILPISSYI-NGQYGGLIKDIYIGAPAIVCKEGVKEVL 288
Query: 296 RYSEFSKFECDLIEKSLQQLRKDVSK 321
+ + S E D S QL+ + K
Sbjct: 289 NF-KISPKELDKFNSSANQLKSYIDK 313
>UniRef50_Q8TWG5 Cluster: Malate dehydrogenase; n=2;
Euryarchaeota|Rep: Malate dehydrogenase - Methanopyrus
kandleri
Length = 317
Score = 49.6 bits (113), Expect = 1e-04
Identities = 31/120 (25%), Positives = 64/120 (53%), Gaps = 6/120 (5%)
Query: 86 NSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPINYLIPMT 145
++D+I+ G+ ++P + L N+ IK + + P V +VT P++ L T
Sbjct: 73 DADVIVMTAGIPRKPGQTRLDLTKDNAAIIKKYLEGVAEENPEAIVLVVTNPVDVL---T 129
Query: 146 AEIMRNHGVYDEKKLFGI-TEIDAIRSQCLYATENNLKANDCYVPVIGGHSDKTIVPLLS 204
++ G+ + ++ G+ T +D++R + L A N+ ++ + +IG H D T+VP++S
Sbjct: 130 YVALKVSGL-PKNRVIGLGTHLDSMRFKVLIAKHFNVHMSEVHTRIIGEHGD-TMVPVIS 187
>UniRef50_Q2S4R2 Cluster: L-lactate dehydrogenase; n=1; Salinibacter
ruber DSM 13855|Rep: L-lactate dehydrogenase -
Salinibacter ruber (strain DSM 13855)
Length = 316
Score = 49.6 bits (113), Expect = 1e-04
Identities = 44/190 (23%), Positives = 80/190 (42%), Gaps = 11/190 (5%)
Query: 20 VTVVGATSEVGQVXXXXXXXXXXITKLVVHD-NKEFTPGVTLDLSQIPSPSRILGLTGED 78
V +VG T VG +++++ D + G +DL + G+T
Sbjct: 7 VGIVG-TGNVGTAAAYAMFNQSLASEILLLDQDTRRAEGEAMDLMH--GQQLVGGITCRA 63
Query: 79 TLERALKNSDLII-AAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEP 137
AL N+ +I+ +AG Q PD + LL N++ + II +L + P + + T P
Sbjct: 64 VEYAALSNAQIIVLSAGASQQSPDETRLGLLQRNAEIFREIIIQLDKHAPNAILVVATNP 123
Query: 138 INYLIPMTAEIMRNHGVYDEKKLFGI-TEIDAIRSQCLYATENNLKANDCYVPVIGGHSD 196
++ L + E+ +++ G T +D R + L + + ++G H D
Sbjct: 124 VDVLTYICQELSSR----PNRRILGTGTLLDTARFRALLGRHYGVDPRSVHAYILGEHGD 179
Query: 197 KTIVPLLSQA 206
VP+ S A
Sbjct: 180 SE-VPIWSNA 188
>UniRef50_Q27743 Cluster: L-lactate dehydrogenase; n=17;
Apicomplexa|Rep: L-lactate dehydrogenase - Plasmodium
falciparum (isolate CDC / Honduras)
Length = 316
Score = 48.4 bits (110), Expect = 3e-04
Identities = 29/133 (21%), Positives = 67/133 (50%), Gaps = 11/133 (8%)
Query: 74 LTGEDTLERALKNSDLIIAAGGLSQRPDISEKA-----LLTANSQFIKSIISKLGRSCPI 128
++G +T + L +D++I G ++ P S+K LL N++ + I + ++CP
Sbjct: 61 VSGSNTYDD-LAGADVVIVTAGFTKAPGKSDKEWNRDDLLPLNNKIMIEIGGHIKKNCPN 119
Query: 129 PFVGIVTEPINYLIPMTAEIMRNHGVYDEKKLFGITEI-DAIRSQCLYATENNLKANDCY 187
F+ +VT P++ ++ +++ H + K+ G+ + D R + + + N+ D
Sbjct: 120 AFIIVVTNPVDVMV----QLLHQHSGVPKNKIIGLGGVLDTSRLKYYISQKLNVCPRDVN 175
Query: 188 VPVIGGHSDKTIV 200
++G H +K ++
Sbjct: 176 AHIVGAHGNKMVL 188
>UniRef50_Q18WQ6 Cluster: Malate dehydrogenase, NAD-dependent; n=2;
Desulfitobacterium hafniense|Rep: Malate dehydrogenase,
NAD-dependent - Desulfitobacterium hafniense (strain
DCB-2)
Length = 320
Score = 48.0 bits (109), Expect = 3e-04
Identities = 57/285 (20%), Positives = 123/285 (43%), Gaps = 16/285 (5%)
Query: 43 ITKLVVHDNKEFTPGVTLDLSQI-PSPSRILGLTGEDTLERALKNSDLIIAAGGLSQRPD 101
I L N+ T G LD+ + P + +TG + L +SD+++ G++++P
Sbjct: 28 IVLLDTQANENPTKGKALDIMEAGPLTRSSVRVTGTSDYQDTL-DSDVVVITAGIARKPG 86
Query: 102 ISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPINYLIPMTAEIMRNHGVYDEKKLF 161
+S L N+ + ++ ++ + P + I++ P++ MT + G + ++
Sbjct: 87 MSRNELCDINAGIVTHVVRQVVQHSPNSTLIILSNPVDI---MTYVAFKESG-FKRNRII 142
Query: 162 GITEI-DAIRSQCLYATENNLKANDCYVPVIGGHSDKTIVPLLSQAK----PTVE-MKEK 215
G + + D+ R + A+E + A D V+G H D +VPL+ P + + E
Sbjct: 143 GQSGVLDSARFRYFVASELKVSAEDVTGFVLGVHGD-DMVPLVRYCSVHGIPIQQLLPEA 201
Query: 216 DLEEFTIKLRNCDG-MITKAKRGCIPNLSVAYSSFLFTKSILDALEGSPAKIHAFVDNND 274
++E+ + R ++ G A + + +LD P +H
Sbjct: 202 EIEKIMERTRQAGSEIVNLLGNGSAYYAPAAALTEMIESILLDKHRVMPCIVH-LEGELG 260
Query: 275 FGTSYFSSLVNLDKNGVKEMVRYSEFSKFECDLIEKSLQQLRKDV 319
+ + + + GV++++ + E DLIE+S+ +R+ +
Sbjct: 261 YQDLVLNVPAVIGRQGVEKILPIDLLPEEE-DLIERSVASIRRGI 304
>UniRef50_A3JXA9 Cluster: L-lactate dehydrogenase; n=1; Sagittula
stellata E-37|Rep: L-lactate dehydrogenase - Sagittula
stellata E-37
Length = 300
Score = 48.0 bits (109), Expect = 3e-04
Identities = 27/117 (23%), Positives = 58/117 (49%), Gaps = 3/117 (2%)
Query: 84 LKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPINYLIP 143
L +D++I A G+SQ+P S LL+ N++ ++++ + R+ P + I + P++ +
Sbjct: 56 LSGADVVILACGVSQKPGESRLELLSRNAEVFRAVVGDVTRAAPDAILLIASNPVDIMTH 115
Query: 144 MTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIGGHSDKTIV 200
+T + G+ + + T +D R + L N+ + V+G H D ++
Sbjct: 116 VTQAL---SGLPAGRVIGSGTILDTARFRWLLGRHLNIAPRSVHAYVLGEHGDTEVL 169
>UniRef50_P22988 Cluster: L-lactate dehydrogenase A; n=19;
Magnoliophyta|Rep: L-lactate dehydrogenase A - Hordeum
vulgare (Barley)
Length = 356
Score = 48.0 bits (109), Expect = 3e-04
Identities = 44/192 (22%), Positives = 78/192 (40%), Gaps = 7/192 (3%)
Query: 9 SSLFTTTRSYQVTVVGATSEVGQVXXXXXXXXXXITKLVVHDN-KEFTPGVTLDLSQIPS 67
SS R +++V+GA VG ++ + D + G LDL +
Sbjct: 35 SSAVPHRRLTKISVIGA-GNVGMAIAQTILTQNLADEIALVDALPDKLRGEALDLQHAAA 93
Query: 68 PSRILGLTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCP 127
+ ++G D KNSDL+I G Q P + LL N + I+ + P
Sbjct: 94 FLPRVRISGTDAA--VTKNSDLVIVTAGARQIPGETRLNLLQRNVALYRKIVPPVAEHSP 151
Query: 128 IPFVGIVTEPINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCY 187
+ +V+ P++ L T + G + + T +D+ R + L A ++ A D
Sbjct: 152 DALLLVVSNPVDVL---TYVAWKLSGFPASRVIGSGTNLDSSRFRFLIAEHLDVNAQDVQ 208
Query: 188 VPVIGGHSDKTI 199
++G H D ++
Sbjct: 209 AYMVGEHGDSSV 220
>UniRef50_Q81K80 Cluster: L-lactate dehydrogenase 2; n=12;
Firmicutes|Rep: L-lactate dehydrogenase 2 - Bacillus
anthracis
Length = 314
Score = 48.0 bits (109), Expect = 3e-04
Identities = 60/267 (22%), Positives = 120/267 (44%), Gaps = 30/267 (11%)
Query: 46 LVVHDNKEFTPGVTLDLSQI----PSPSRILGLTGEDTLERALKNSDLIIAAGGLSQRPD 101
++V N+ G +DLS PSP+++ + D K++DL++ GL Q+P
Sbjct: 34 VLVDVNEAKAEGEAMDLSHAVPFSPSPTKVWSGSYADC-----KDADLVVITAGLPQKPG 88
Query: 102 ISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPINYLIPMTAEIMRNHGVYDEKKLF 161
+ L+ N++ K I+ + S I T P++ L +T + G+ E+ +
Sbjct: 89 ETRLDLVEKNTKIFKQIVRGIMDSGFDGIFLIATNPVDILTYVT---WKESGLPKERVIG 145
Query: 162 GITEIDAIRSQCLYATENNLKANDCYVPVIGGHSDKTIVPLLSQAKPTV----------- 210
T +D+ R + + ++ + + ++G H D T +P+ S A V
Sbjct: 146 SGTTLDSARFRYMLGDYLDVDPRNVHAYIVGEHGD-TELPVWSHATIGVQKLETILANNE 204
Query: 211 EMKEKDLEEFTIKLRNCDGMITKAKRGCIPNLSVAYSSFLFTKSILDALEGSPAKIHAFV 270
+ K++DL++ +R+ I + K + S TK+IL+ E S + A++
Sbjct: 205 QYKQEDLDKIFENVRDAAYHIIERKGATY--YGIGMSLLRVTKAILNN-ENSVLTVSAYL 261
Query: 271 DNNDFG--TSYFSSLVNLDKNGVKEMV 295
+ +G +Y +++ GV+E+V
Sbjct: 262 E-GQYGEKDAYVGVPAVINREGVREIV 287
>UniRef50_Q8ZVB2 Cluster: Malate dehydrogenase; n=14;
Thermoprotei|Rep: Malate dehydrogenase - Pyrobaculum
aerophilum
Length = 309
Score = 47.6 bits (108), Expect = 4e-04
Identities = 43/191 (22%), Positives = 90/191 (47%), Gaps = 12/191 (6%)
Query: 20 VTVVGATSEVGQVXXXXXXXXXXITKLVVHDNKEFTP-GVTLDLSQIPSPSRILGLTGE- 77
+T++G+ VG K+++ D + P G LD++ + S ILGL E
Sbjct: 2 ITIIGS-GRVGTAAAVIMGLMKLDNKILLIDIVKGLPQGEALDMNHMSS---ILGLDVEY 57
Query: 78 --DTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVT 135
+ ++ SDLII GL ++P ++ + LL AN++ + I ++ + P V + T
Sbjct: 58 VGSNEYKDIEGSDLIIVTAGLPRKPGMTREQLLEANAKIVAEIGREIKKYAPDSIVILTT 117
Query: 136 EPINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIGGHS 195
P++ MT + + G + +++ G + + YA + + +P++ G
Sbjct: 118 NPLD---AMTYVMWKATG-FPRERVIGFSGVLDAGRLAFYAAKKLGISPASILPIVLGQH 173
Query: 196 DKTIVPLLSQA 206
+++ P+ S++
Sbjct: 174 GESMFPVPSKS 184
>UniRef50_Q6JH30 Cluster: Lactate dehydrogenase; n=3; Plasmodium
(Plasmodium)|Rep: Lactate dehydrogenase - Plasmodium
vivax
Length = 299
Score = 47.2 bits (107), Expect = 6e-04
Identities = 30/133 (22%), Positives = 66/133 (49%), Gaps = 11/133 (8%)
Query: 74 LTGEDTLERALKNSDLIIAAGGLSQRPDISEKA-----LLTANSQFIKSIISKLGRSCPI 128
+TG ++ + LK +D++I G ++ P S+K LL N++ + I + CP
Sbjct: 54 VTGSNSYDD-LKGADVVIVTAGFTKAPGKSDKEWNRDDLLPLNNKIMIEIGGHIKNLCPN 112
Query: 129 PFVGIVTEPINYLIPMTAEIMRNHGVYDEKKLFGITEI-DAIRSQCLYATENNLKANDCY 187
F+ +VT P++ ++ +++ H + K+ G+ + D R + + + N+ D
Sbjct: 113 AFIIVVTNPVDVMV----QLLFEHSGVPKNKIIGLGGVLDTSRLKYYISQKLNVCPRDVN 168
Query: 188 VPVIGGHSDKTIV 200
++G H +K ++
Sbjct: 169 ALIVGAHGNKMVL 181
>UniRef50_UPI0000519EC7 Cluster: PREDICTED: similar to
Ecdysone-inducible gene L3 CG10160-PA; n=2;
Apocrita|Rep: PREDICTED: similar to Ecdysone-inducible
gene L3 CG10160-PA - Apis mellifera
Length = 409
Score = 46.8 bits (106), Expect = 8e-04
Identities = 35/119 (29%), Positives = 57/119 (47%), Gaps = 4/119 (3%)
Query: 86 NSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPINYLIPMT 145
NS +I+ A G Q S L+ NS+ +KSII L P + +V+ P++ L +T
Sbjct: 164 NSKVIVLAAGARQMKGESRLDLVQRNSEILKSIIPTLVGYSPNAVILVVSNPVDILSWLT 223
Query: 146 AEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIGGHSDKTIVPLLS 204
+I G+ + + T +D+ R + L A + + + +IG H D VPL S
Sbjct: 224 WKI---SGLPASRVIGTGTHVDSARFRFLIADRLGIAPSSVHATIIGEHGDSQ-VPLWS 278
>UniRef50_Q8IE66 Cluster: Oxidoreductase, putative; n=6;
Plasmodium|Rep: Oxidoreductase, putative - Plasmodium
falciparum (isolate 3D7)
Length = 334
Score = 46.8 bits (106), Expect = 8e-04
Identities = 46/199 (23%), Positives = 94/199 (47%), Gaps = 17/199 (8%)
Query: 13 TTTRSYQVTVVGATSEVGQVXXXXXXXXXXITKLVVHD-NKEFTPGVTLDLSQIPSPSRI 71
T+ + +++V+GA ++G + +V+HD K+ G LD+ +R
Sbjct: 2 TSVKHPKISVLGA-GDIG-CALAHMICEKNLGDVVLHDFRKDLPKGRALDILHTRPLNRS 59
Query: 72 -LGLTGEDTLERALKNSDLIIAAGGLSQRP------DISEKALLTANSQFIKSIISKLGR 124
+ + G + + +K+S +++ +S+R + EK + T+N + +K + L +
Sbjct: 60 RINILGTNEITD-IKDSLVVVVTIEVSEREFAEFDEEDLEKQVYTSNVKLLKEVAKSLKK 118
Query: 125 SCPIPFVGIVTEPINYLIPMTAEIMRNHGVYDEKKLFGITEI-DAIRSQCLYATENNLKA 183
CP FV + T P++ + A++++ H K+ G+ + + R + A + +
Sbjct: 119 HCPQAFVVVTTSPVDCM----AKVLQEHANIPPHKICGMAGVLHSARLRHNLAEKLRVNP 174
Query: 184 NDCYVPVIGGHSDKTIVPL 202
D VIG H DK +VPL
Sbjct: 175 GDVQGFVIGAHGDK-MVPL 192
>UniRef50_Q6LZI3 Cluster: Malate dehydrogenase; n=5;
Methanococcus|Rep: Malate dehydrogenase - Methanococcus
maripaludis
Length = 314
Score = 46.4 bits (105), Expect = 0.001
Identities = 39/192 (20%), Positives = 92/192 (47%), Gaps = 14/192 (7%)
Query: 20 VTVVGATSEVGQVXXXXXXXXXXITK--LVVHDNK-EFTPGVTLDLSQIPSPS---RILG 73
V+++GA+ ++G V I L+ + G+ +DL + + +
Sbjct: 3 VSIIGASGKIGSVLSLLLAKESHIKNINLIARSSSINKLKGLKMDLYDAMAAAGQDTDID 62
Query: 74 LTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGI 133
+ +D L NSD+ I G+++ ++S L+ N++ +K+ + + + +
Sbjct: 63 ICCDDDLS-CTANSDITIITAGMARTGEMSRIDLMKGNAKIVKNYVKNIANFGDTK-IFM 120
Query: 134 VTEPINYLIPMTAEIMRNHGVYDEKKLFGI-TEIDAIRSQCLYATENNLKANDCYVPVIG 192
++ P++ MT + + G Y++ ++FG+ T +D++R + A + +D ++G
Sbjct: 121 ISNPVDL---MTYKALIESG-YEKNQVFGLGTHLDSMRFKVAVAKHFEVHLDDVRTRIVG 176
Query: 193 GHSDKTIVPLLS 204
H D ++VP++S
Sbjct: 177 EHGD-SMVPVIS 187
>UniRef50_Q9P7P7 Cluster: Probable L-lactate dehydrogenase; n=2;
Ascomycota|Rep: Probable L-lactate dehydrogenase -
Schizosaccharomyces pombe (Fission yeast)
Length = 330
Score = 46.4 bits (105), Expect = 0.001
Identities = 42/185 (22%), Positives = 75/185 (40%), Gaps = 7/185 (3%)
Query: 16 RSYQVTVVGATSEVGQVXXXXXXXXXXITKLVVHD-NKEFTPGVTLDLSQIPSPSRILGL 74
+S ++ +VGA VG ++V+ D NK+ G +DL+ S +
Sbjct: 19 KSIKIVIVGA-GNVGSTTAFTLLLSGLAAEIVIIDLNKKKAEGEAMDLNHAAPLSHETRV 77
Query: 75 TGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIV 134
D + K++ ++ G +Q+P + LL AN K I+ ++ + + +
Sbjct: 78 YLGDYKD--CKDATAVVITAGKNQKPGETRMDLLKANISIFKEILREVTKYTKDAILLVA 135
Query: 135 TEPINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIGGH 194
T P++ L T ++ G E+ + T ID R Q L L +IG H
Sbjct: 136 TNPVDVLTYATLKLT---GFPAERVIGSGTIIDTARFQYLIGKLYGLDPQSVNADIIGEH 192
Query: 195 SDKTI 199
D +
Sbjct: 193 GDSEL 197
>UniRef50_Q7UY63 Cluster: L-lactate/malate dehydrogenase; n=2;
Planctomycetaceae|Rep: L-lactate/malate dehydrogenase -
Rhodopirellula baltica
Length = 304
Score = 46.0 bits (104), Expect = 0.001
Identities = 48/183 (26%), Positives = 87/183 (47%), Gaps = 13/183 (7%)
Query: 19 QVTVVGATSEVGQVXXXXXXXXXXITKLVV-HDNKEFTPGVTLDLSQIPS--PSRILGLT 75
++T+VG T VG ++L++ + ++E G LDL+ + S I +
Sbjct: 2 KITLVG-TGRVGSAIAFALTINPLASELLLLNRSREKAEGDALDLTHAAALVDSNIKISS 60
Query: 76 GEDTLERALKNSDLIIAAGGLSQR-PDISEKALLTANSQFIKSIISKLGRSCPIPFVGIV 134
GE K+SD+II + R P+ + + N ++ + L ++ P V +V
Sbjct: 61 GEIADS---KDSDVIIFTASVPFRYPNQTRLEMGIDNMPILRDWMPGLAKASPNAIVVMV 117
Query: 135 TEPINYLIPMTAEIMRNHGVYDEKKLFGI-TEIDAIRSQCLYATENNLKANDCYVPVIGG 193
+ P++ L E +R G +D K++ G T +D+IR + L +TE + A D ++G
Sbjct: 118 SNPVDAL---AYETIRLTG-FDPKRVIGTGTLVDSIRYRALLSTELKIHAQDIRAYILGE 173
Query: 194 HSD 196
H D
Sbjct: 174 HGD 176
>UniRef50_P20619 Cluster: L-lactate dehydrogenase X; n=14;
Bacillales|Rep: L-lactate dehydrogenase X - Bacillus
psychrosaccharolyticus
Length = 319
Score = 46.0 bits (104), Expect = 0.001
Identities = 67/295 (22%), Positives = 131/295 (44%), Gaps = 32/295 (10%)
Query: 19 QVTVVGATSEVGQVXXXXXXXXXXITKLVVHD-NKEFTPGVTLDLSQ----IPSPSRILG 73
+V ++GA S VG +LV+ D N++ G +DL+ P+P++
Sbjct: 8 RVALIGAGS-VGSSYAFALLNQSITEELVIIDVNEDKAMGDAMDLNHGKIFAPNPTKTWY 66
Query: 74 LTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGI 133
+D K +D++ G +Q+P + L+ N + KS++ ++ S I
Sbjct: 67 GNYDDC-----KEADIVCICAGANQKPGETRLDLVEKNLKIFKSLVDQVMASGFDGIFLI 121
Query: 134 VTEPINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIGG 193
T P++ L T + G+ E+ + T +D+ R + L ++ + + +IG
Sbjct: 122 ATNPVDIL---TYATWKFSGLPKERVIGSGTILDSGRFRFLLGEYFDIAPANVHAHIIGE 178
Query: 194 HSDKTIVPLLSQAK----PTVEM-------KEKDLEEFTIKLRNCDGMITKAKRGCIPNL 242
H D T +P+ S A P E+ K +DL++ + +R+ I K K+G
Sbjct: 179 HGD-TELPVWSHADIGGVPVEELITRNPEYKMEDLDQLFVNVRDAAYHIIK-KKGA-TYY 235
Query: 243 SVAYSSFLFTKSILDALEGSPAKIHAFVDNNDFGTS--YFSSLVNLDKNGVKEMV 295
+A TK+IL+ E S + ++D ++G Y +++ G++E++
Sbjct: 236 GIAMGLARITKAILNN-ENSVLTVSTYLD-GEYGEKDVYIGVPAVVNRTGIREIL 288
>UniRef50_P59390 Cluster: L-lactate dehydrogenase 2; n=8;
Lactobacillus|Rep: L-lactate dehydrogenase 2 -
Lactobacillus plantarum
Length = 309
Score = 44.8 bits (101), Expect = 0.003
Identities = 63/285 (22%), Positives = 115/285 (40%), Gaps = 17/285 (5%)
Query: 19 QVTVVGATSEVGQVXXXXXXXXXXITKLVVHDN-KEFTPGVTLDLSQIPSPSRILGL-TG 76
+V +VG S VG + +LV+ D K G DL + + + + TG
Sbjct: 7 KVVIVGDGS-VGSSFAFSLVQNCALDELVIVDLVKTHAEGDVKDLEDVAAFTNATNIHTG 65
Query: 77 EDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTE 136
E R ++D+++ G+ ++P S L+ N++ ++SI+ + S I +
Sbjct: 66 EYADAR---DADIVVITAGVPRKPGESRLDLINRNTKILESIVKPVVASGFNGCFVISSN 122
Query: 137 PINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIGGHSD 196
P++ L MT R G + + T +D R + A + N+ V+G H D
Sbjct: 123 PVDILTSMT---QRLSGFPRHRVIGTGTSLDTARLRVALAQKLNVATTAVDAAVLGEHGD 179
Query: 197 KTIV---PLLSQAKP--TVEMKEKDLE-EFTIKLRNCDGMITKAKRGCIPNLSVAYSSFL 250
+IV ++ A+P TV + + E +R G I K VA S
Sbjct: 180 SSIVNFDEIMINAQPLKTVTTVDDQFKAEIEQAVRGKGGQIISQKGATF--YGVAVSLMQ 237
Query: 251 FTKSILDALEGSPAKIHAFVDNNDFGTSYFSSLVNLDKNGVKEMV 295
++IL+ A Y S +++NG+++++
Sbjct: 238 ICRAILNDENAELIVSAALSGQYGINDLYLGSPAIINRNGLQKVI 282
>UniRef50_A4L2P0 Cluster: L-lactate dehydrogenase; n=4;
Lactobacillus|Rep: L-lactate dehydrogenase -
Lactobacillus reuteri
Length = 312
Score = 44.4 bits (100), Expect = 0.004
Identities = 32/136 (23%), Positives = 65/136 (47%), Gaps = 8/136 (5%)
Query: 61 DLSQIPSPSRILGLTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIIS 120
D++ + +P +I T ED + +D+++ G+ ++P + L+ N+ +KSII
Sbjct: 54 DITPLTNPVKIYAGTYEDAAD-----ADVVVITAGIPRKPGETRLDLVNKNTTILKSIIK 108
Query: 121 KLGRSCPIPFVGIVTEPINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENN 180
+ +S F G+ N + +T R G E+ + T +D++R + L + + +
Sbjct: 109 PIVKS---GFTGVFVISSNPVDILTTIAQRISGFPKERVIGTGTSLDSMRLRVLLSKKLH 165
Query: 181 LKANDCYVPVIGGHSD 196
L N ++G H D
Sbjct: 166 LSVNVIDALMLGEHGD 181
>UniRef50_A7DRG3 Cluster: Lactate/malate dehydrogenase; n=1;
Candidatus Nitrosopumilus maritimus SCM1|Rep:
Lactate/malate dehydrogenase - Candidatus Nitrosopumilus
maritimus SCM1
Length = 304
Score = 44.0 bits (99), Expect = 0.005
Identities = 61/310 (19%), Positives = 132/310 (42%), Gaps = 20/310 (6%)
Query: 20 VTVVGATSEVGQVXXXXXXXXXXITKLVVHDNKEFTP-GVTLDLSQIPSPSRI-LGLTGE 77
+T++G+ +VG ++++ D E P G +D++ + S I + + G
Sbjct: 2 ITIIGS-GKVGGDAALFSALKRLDDQILLLDVAEGLPQGEAMDINHMLSEQGIDVEVKGS 60
Query: 78 DTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEP 137
+ E +K S++++ G ++P ++ LL N+ +KS++ + + + VT P
Sbjct: 61 NNFED-MKGSNIVVVVAGSGRKPGMTRMDLLKINASIVKSVVENVKKYADDSMIIPVTNP 119
Query: 138 INYLIPMTAEIMRNHGVYDEKKLFGI-TEIDAIRSQCLYATENNLKANDCYVPVIGGHSD 196
++ PM A I +D ++FG+ +D R + + VIG H +
Sbjct: 120 LD---PM-AYITYKVSGFDRSRVFGMGGMLDLSRFRQFIHEATGHSRDSIRALVIGEHGE 175
Query: 197 KTI-VPLLSQAK----PTVEMKEKDLEEFTIKLRNCDGMITKAKRGCIPNLSVAYSSFLF 251
+ +P S P++ KEK LEE + + + K + A S+ +
Sbjct: 176 NMLPLPRFSSVSGIPLPSLLPKEK-LEELVQNTKQVAAKVIELKGATVHAPGNAISA-IV 233
Query: 252 TKSILDALEGSPAKIHAFVDNN-DFGTSYFSSLVNLDKNGVKEMVRYSEFSKFECDLIEK 310
+ D + P + ++D D + KNGV++++ + + E + K
Sbjct: 234 EAVVRDRKQVIP--VATYLDGEYDHSDVTIGVPAVIGKNGVEKIIEL-DLNDEEKQVFNK 290
Query: 311 SLQQLRKDVS 320
+++ ++ +S
Sbjct: 291 AVENVKGALS 300
>UniRef50_Q6A9C3 Cluster: L-lactate dehydrogenase; n=2;
Propionibacterium acnes|Rep: L-lactate dehydrogenase -
Propionibacterium acnes
Length = 319
Score = 43.6 bits (98), Expect = 0.007
Identities = 47/202 (23%), Positives = 86/202 (42%), Gaps = 12/202 (5%)
Query: 8 ISSLFTTTRSYQVTVVGATSEVGQVXXXXXXXXXXITKLVVHD-NKEFTPGVTLDLSQIP 66
+S+ T R+ +++VVGA S VG + ++D K+ DL+
Sbjct: 1 MSTFDATRRASKISVVGAGS-VGSSLAYACLIRGSAGLVSLYDIAKDKVEAEVADLAHGT 59
Query: 67 --SPSRILGLTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGR 124
+P+ ++G G D + A +SD++ G Q+P + L N+ ++S++ +L
Sbjct: 60 QFTPASVMG--GADVHDTA--DSDVVFITAGARQKPGQTRLDLAGVNANILRSLMPQLVE 115
Query: 125 SCPIPFVGIVTEPINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKAN 184
P +VT P + L + E G+ + T +D R + L N++
Sbjct: 116 QSPNALFVLVTNPCDVLTVVAQEAT---GLPANRVFSTGTMLDTSRLRWLIRQWANVEQR 172
Query: 185 DCYVPVIGGHSDKTIVPLLSQA 206
+ ++G H D PL S A
Sbjct: 173 HVHATIVGEHGDSEF-PLWSTA 193
>UniRef50_Q6F0L9 Cluster: L-lactate dehydrogenase; n=6;
Mollicutes|Rep: L-lactate dehydrogenase - Mesoplasma
florum (Acholeplasma florum)
Length = 317
Score = 43.6 bits (98), Expect = 0.007
Identities = 49/189 (25%), Positives = 78/189 (41%), Gaps = 16/189 (8%)
Query: 17 SYQVTVVGATSEVGQVXXXXXXXXXXITKLVVHD-NKEFTPGVTLDLSQ----IPSPSRI 71
S +V +VG T VG + V+ D N + G +D+ + P I
Sbjct: 5 SNKVVLVG-TGAVGMSFIYSAVNQGLAEEYVLIDVNTKAAEGNAIDIQDTMAVLDKPFTI 63
Query: 72 LGLTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFV 131
T ED K++DLI+ G QRP + L+ NS+ +K I + S F
Sbjct: 64 KAGTYEDC-----KDADLIVITAGRPQRPGETRLELIADNSRIMKGIAEAIKAS---GFN 115
Query: 132 GIVTEPINYLIPMTAEIMRNHGVYDEKKLFGI-TEIDAIRSQCLYATENNLKANDCYVPV 190
G+ N +T + G YDE + G T +D+ R + L A + N+ +
Sbjct: 116 GVTVIASNPCDVLTTVYQQVTG-YDEHSVVGAGTTLDSARLRRLVAEKLNVAPKSVNAYI 174
Query: 191 IGGHSDKTI 199
+G H D ++
Sbjct: 175 MGEHGDSSV 183
>UniRef50_Q7NG49 Cluster: L-lactate dehydrogenase; n=4;
Cyanobacteria|Rep: L-lactate dehydrogenase - Gloeobacter
violaceus
Length = 330
Score = 43.6 bits (98), Expect = 0.007
Identities = 28/119 (23%), Positives = 55/119 (46%), Gaps = 4/119 (3%)
Query: 88 DLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPINYLIPMTAE 147
D+++ G QR + +L+ N + + +I ++ CP + +V+ P++ MT
Sbjct: 89 DVVVITAGARQREGETRLSLVQRNVEIFRGLIGEIMEHCPNAILLVVSNPVDV---MTYV 145
Query: 148 IMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIGGHSDKTIVPLLSQA 206
M+ G+ + + T +D R + L A + + +IG H D VP+ S+A
Sbjct: 146 AMKLAGLPPSRVIGSGTVLDTARFRYLLAERLRVDPRSLHAYIIGEHGDSE-VPVWSRA 203
>UniRef50_A4A2L6 Cluster: L-lactate dehydrogenase; n=4;
Bacteria|Rep: L-lactate dehydrogenase - Blastopirellula
marina DSM 3645
Length = 313
Score = 43.2 bits (97), Expect = 0.010
Identities = 45/193 (23%), Positives = 84/193 (43%), Gaps = 13/193 (6%)
Query: 19 QVTVVGATSEVGQVXXXXXXXXXXITKLVVHD-NKEFTPGVTLDLSQIPSPSRILGLTGE 77
+V+++G VG ++ + D N + G LDL +PS +
Sbjct: 2 KVSIIGGGGLVGSCAAFALQCGGIAREIALLDLNADLAGGHALDLLH-GAPSVADQVITS 60
Query: 78 DTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPI---PFVGIV 134
E + +SD+I GL ++PD S L+ N SI+ + +S + +V
Sbjct: 61 GGYEH-IPDSDVICITAGLRRKPDESRLDLINRNVDLFLSILDSV-KSAGVKKDAICFVV 118
Query: 135 TEPINYLIPMTAEIMRNHGVYDEKKLFGI-TEIDAIRSQCLYATENNLKANDCYVPVIGG 193
+ P++ L + A+ + ++ G+ T++D IR + L A E L ++G
Sbjct: 119 SNPVDILTYLAAQRLN----LPTSRVIGLGTQLDTIRFRALIAQEMKLPPTQVKALILGE 174
Query: 194 HSDKTIVPLLSQA 206
H D +++P+ S A
Sbjct: 175 HGD-SMLPVWSAA 186
>UniRef50_Q838C9 Cluster: L-lactate dehydrogenase 2; n=9;
Bacilli|Rep: L-lactate dehydrogenase 2 - Enterococcus
faecalis (Streptococcus faecalis)
Length = 317
Score = 43.2 bits (97), Expect = 0.010
Identities = 49/244 (20%), Positives = 109/244 (44%), Gaps = 18/244 (7%)
Query: 85 KNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPINYLIPM 144
+++D+++ G +Q+P S L++ N++ +K+I++ + +S F GI+ N + +
Sbjct: 72 QDADIVVITAGANQKPGQSRLDLVSINAEIMKTIVNNIMKS---GFDGILVIASNPVDVL 128
Query: 145 TAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIGGHSDKTIV---- 200
T + G+ + + T +D R + + + + + +IG H D +
Sbjct: 129 TYVAWQASGLPVSRVIGTGTTLDTTRFRKELSQRLAIDPRNVHGYIIGEHGDSEVAVWSH 188
Query: 201 ------PLLSQAKPTVEMKEKDLEEFTIKLRNCDGMITKAKRGCIPNLSVAYSSFLFTKS 254
P+L T + DL + K++N I K+ + S+ K+
Sbjct: 189 TMIGTKPILEIVDTTERLTSDDLPIISDKVKNTAYEIIDRKQATY--YGIGMSTARIVKA 246
Query: 255 ILDALEGSPAKIHAFVDNNDFGTSYFSSLVNLDKN-GVKEMVRYSEFSKFECDLIEKSLQ 313
IL+ E + + A++D F+ + + N GV +++ + + E +L +KS+
Sbjct: 247 ILNN-EQAILPVSAYLDGQYGQQDVFTGIPAVVGNQGVTDIIELN-LNAAEKELFQKSVT 304
Query: 314 QLRK 317
QL++
Sbjct: 305 QLKQ 308
>UniRef50_Q0UX88 Cluster: L-lactate dehydrogenase; n=2;
Phaeosphaeria nodorum|Rep: L-lactate dehydrogenase -
Phaeosphaeria nodorum (Septoria nodorum)
Length = 326
Score = 42.7 bits (96), Expect = 0.013
Identities = 54/228 (23%), Positives = 93/228 (40%), Gaps = 18/228 (7%)
Query: 20 VTVVGATSEVGQVXXXXXXXXXXITKLVVHDNK-EFTPGVTLDLSQIPSPSRILGLTGED 78
+ V+G +VG T++++ D K G DLS S S +
Sbjct: 10 IAVIGC-GDVGATLAYTLILQSICTEVLLVDPKTSLLDGQVRDLSDATSRSTKVR---SG 65
Query: 79 TLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPI 138
T + A +D+++ G Q+ S +LLT N + SI + + +V P+
Sbjct: 66 THQEA-GQADIVVITAGAKQKTGESRLSLLTRNLNILSSIFDSMKPISAHTVLLLVANPV 124
Query: 139 NYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIGGHSDKT 198
+ L+ A +M G+ + + L T +D+ R + + A + + + V+G H D
Sbjct: 125 DILV-YFARMM--SGLPENQVLGTGTSLDSARLRGVLAGKAGVSPSSIDAYVLGEHGDSQ 181
Query: 199 IVPLLSQAKPTV--------EMKEKDLEEFTIKLRNCDGMITKAKRGC 238
V S + T E+ ++ EE +K R G I AK GC
Sbjct: 182 FVAWSSASIGTTPLRLALGDELTDEFKEEVAMKTRGAAGAIIAAK-GC 228
>UniRef50_P0C0J4 Cluster: L-lactate dehydrogenase; n=5; Mycoplasma
hyopneumoniae|Rep: L-lactate dehydrogenase - Mycoplasma
hyopneumoniae
Length = 315
Score = 42.7 bits (96), Expect = 0.013
Identities = 37/154 (24%), Positives = 61/154 (39%), Gaps = 4/154 (2%)
Query: 47 VVHDNKEFTPGVTLDLSQIPSPSRILGLTGEDTLERALKNSDLIIAAGGLSQRPDISEKA 106
++ N +F G D S S ++ + LK++D I+ G Q+P +
Sbjct: 33 IIDINPDFADGNAFDFEDA-SASLPFPISVSRYEYKDLKDADFIVITAGRPQKPGETRLE 91
Query: 107 LLTANSQFIKSIISKLGRSCPIPFVGIVTEPINYLIPMTAEIMRNHGVYDEKKLFGITEI 166
L+ N + I+ I K+ S IV P++ + T G D+K + T +
Sbjct: 92 LVADNIRIIREIALKVKESGFSGISIIVANPVDII---TRAYRDASGFSDQKVIGSGTVL 148
Query: 167 DAIRSQCLYATENNLKANDCYVPVIGGHSDKTIV 200
D R Q A + N V+G H D + V
Sbjct: 149 DTARLQFAIAKRAKVSPNSVQAYVMGEHGDSSFV 182
>UniRef50_UPI000038D9FF Cluster: COG0039: Malate/lactate
dehydrogenases; n=2; Nostoc punctiforme PCC 73102|Rep:
COG0039: Malate/lactate dehydrogenases - Nostoc
punctiforme PCC 73102
Length = 317
Score = 42.3 bits (95), Expect = 0.017
Identities = 33/119 (27%), Positives = 54/119 (45%), Gaps = 6/119 (5%)
Query: 84 LKNSDLII-AAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPINYLI 142
L +SD+II G+ + + L+ N++ I+S I +L R P V I++ P++ L
Sbjct: 71 LADSDIIIIVTAGVQPKLGQTRLDTLSDNAEIIRSTIKELDRVAPNSIVIIISNPVDVL- 129
Query: 143 PMTAEIMRNHGVYDEKKLFGI-TEIDAIRSQCLYATENNLKANDCYVPVIGGHSDKTIV 200
I + E +FG T +D R + + N+ D + VIG H D V
Sbjct: 130 ---TRIAQATSTRAENLIFGSGTVLDTARLRYQLGKQLNVAKQDIHAYVIGEHGDSQFV 185
>UniRef50_A2SNY0 Cluster: Malate/lactate dehydrogenases-like
protein; n=1; Methylibium petroleiphilum PM1|Rep:
Malate/lactate dehydrogenases-like protein - Methylibium
petroleiphilum (strain PM1)
Length = 432
Score = 42.3 bits (95), Expect = 0.017
Identities = 31/133 (23%), Positives = 59/133 (44%), Gaps = 5/133 (3%)
Query: 74 LTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGI 133
L+G D L AL ++ I+ G ++P +S L N++ + S+ + P + I
Sbjct: 181 LSGSDDLV-ALAGAEYIVITAGKPRQPGMSRTDLTVVNAEIMTSVCRGIRTHAPNSTLVI 239
Query: 134 VTEPINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIGG 193
V+ P+ + + A+ G +E+ L +D+ R L + + +G
Sbjct: 240 VSNPLEEMTHLAAQ---QTGFPEERVLGMAGVLDSARFCALVGLTGKARPQEVRAVALGS 296
Query: 194 HSDKTIVPLLSQA 206
H + ++P LSQA
Sbjct: 297 HGPEMVIP-LSQA 308
>UniRef50_A5KJY5 Cluster: Putative uncharacterized protein; n=2;
Ruminococcus|Rep: Putative uncharacterized protein -
Ruminococcus torques ATCC 27756
Length = 316
Score = 41.5 bits (93), Expect = 0.029
Identities = 36/173 (20%), Positives = 78/173 (45%), Gaps = 8/173 (4%)
Query: 29 VGQVXXXXXXXXXXITKLVVHD-NKEFTPGVTLDLSQ-IPSPSRILGLTGEDTLERALKN 86
VG +++V+ D NK G +D+S +P + GE + +
Sbjct: 15 VGSTIAYTLMQKGLFSEMVLLDANKAKAEGEAMDISHGLPFTHAMDIYAGE---YEDIAD 71
Query: 87 SDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPINYLIPMTA 146
+ ++I G +Q+P + L+ N+ ++SII ++ R + IV+ P++ L T
Sbjct: 72 ASVVIITAGANQKPGETRLDLVQKNAAIMRSIIKEIKRVNCEGILLIVSNPVDIL---TE 128
Query: 147 EIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIGGHSDKTI 199
+R G E+ + T +D R + + + + ++ + + + ++G H D +
Sbjct: 129 VALRESGFPKERVIGSGTVLDTARLKYIISEKLDVDSRNVHAFIVGEHGDSEL 181
>UniRef50_Q4SRH5 Cluster: L-lactate dehydrogenase; n=4;
Euteleostomi|Rep: L-lactate dehydrogenase - Tetraodon
nigroviridis (Green puffer)
Length = 360
Score = 41.1 bits (92), Expect = 0.038
Identities = 33/121 (27%), Positives = 59/121 (48%), Gaps = 4/121 (3%)
Query: 86 NSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPINYLIPMT 145
NS L++ G+ Q+ S L+ N KSII ++ + P + +V+ P++ L +T
Sbjct: 89 NSRLVVVTAGVRQQEGESRLNLVQRNVNVFKSIIPQIIKYSPNCTLIVVSNPVDVLTYVT 148
Query: 146 AEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIGGHSDKTIVPLLSQ 205
++ G+ + + T +D+ R + L A + A+ V+G H D T VP+ S
Sbjct: 149 WKL---SGLPKHRVIGSGTNLDSARFRYLMAERLGIHASSFNGWVLGEHGD-TSVPVWSG 204
Query: 206 A 206
A
Sbjct: 205 A 205
>UniRef50_Q03BE6 Cluster: L-lactate dehydrogenase; n=1;
Lactobacillus casei ATCC 334|Rep: L-lactate
dehydrogenase - Lactobacillus casei (strain ATCC 334)
Length = 312
Score = 40.7 bits (91), Expect = 0.051
Identities = 25/112 (22%), Positives = 54/112 (48%), Gaps = 3/112 (2%)
Query: 85 KNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPINYLIPM 144
K +D+I+ G++Q+P + LL N++ +K I + S F+ + + P++ L +
Sbjct: 70 KYADIIVITAGIAQKPGQTRLQLLAINAKIMKEITHNIMASGFNGFILVASNPVDVLAEL 129
Query: 145 TAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIGGHSD 196
+++ G+ + L T +D+ R + N+ A + ++G H D
Sbjct: 130 ---VLQESGLPRNQVLGSGTALDSARLRSEIGLRYNVDARIVHGYIMGEHGD 178
>UniRef50_A2Q223 Cluster: Lactate/malate dehydrogenase, alpha/beta
C-terminal domain containing protein; n=1; Medicago
truncatula|Rep: Lactate/malate dehydrogenase, alpha/beta
C-terminal domain containing protein - Medicago
truncatula (Barrel medic)
Length = 205
Score = 40.7 bits (91), Expect = 0.051
Identities = 18/39 (46%), Positives = 26/39 (66%)
Query: 188 VPVIGGHSDKTIVPLLSQAKPTVEMKEKDLEEFTIKLRN 226
VPV+GGH+ TI+PLLSQAK ++ E T +++N
Sbjct: 38 VPVVGGHAGVTILPLLSQAKSPSSFTAEETEYLTNRIQN 76
>UniRef50_P47698 Cluster: L-lactate dehydrogenase; n=2;
Mycoplasma|Rep: L-lactate dehydrogenase - Mycoplasma
genitalium
Length = 312
Score = 40.7 bits (91), Expect = 0.051
Identities = 40/163 (24%), Positives = 70/163 (42%), Gaps = 6/163 (3%)
Query: 46 LVVHDNKEFTPGVTLDLSQIPSPSRILGLTGEDTLERALKNSDLIIAAGGLSQRPDISEK 105
+++ N++ G DL S G + LK+ D I + G Q+ +
Sbjct: 32 MIIDINEKAKVGNVFDLQDASSSCPNFGKVVAGEYSQ-LKDYDFIFISAGRPQKQGGETR 90
Query: 106 A-LLTANSQFIKSIISKLGRSCPIPFVGIVTEPINYLIPMTAEIMRNHGVYDEKKLFGIT 164
LL N + +KSI ++ +S F G+ N + M+ ++ G K + T
Sbjct: 91 LQLLEGNVEIMKSIAKEIKKS---GFNGVTLIASNPVDIMSYTYLKVTGFEPNKVIGSGT 147
Query: 165 EIDAIRSQCLYATENNLKANDCYVPVIGGHSDKTIVPLLSQAK 207
+D+ R + AT+ + + D VIG H D + V ++S AK
Sbjct: 148 LLDSARLRYAIATKYQMSSKDVQAYVIGEHGDSS-VSIISSAK 189
>UniRef50_P50933 Cluster: L-lactate dehydrogenase; n=7;
Bacteria|Rep: L-lactate dehydrogenase - Deinococcus
radiodurans
Length = 304
Score = 39.9 bits (89), Expect = 0.089
Identities = 23/117 (19%), Positives = 52/117 (44%), Gaps = 5/117 (4%)
Query: 84 LKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPINYLIP 143
L ++ ++I G +Q+P S LL N+ + ++ ++ R+ P + + + P++ L
Sbjct: 65 LADAQVVILTAGANQKPGESRLDLLEKNADIFRELVPQITRAAPDAVLLVTSNPVDLLTD 124
Query: 144 MTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIGGHSDKTIV 200
+ ++ V T +D+ R + L A + + V+G H D ++
Sbjct: 125 LATQLAPGQPVIGSG-----TVLDSARFRHLMAQHAGVDGTHAHGYVLGEHGDSEVL 176
>UniRef50_A7DSJ4 Cluster: Lactate/malate dehydrogenase; n=1;
Candidatus Nitrosopumilus maritimus SCM1|Rep:
Lactate/malate dehydrogenase - Candidatus Nitrosopumilus
maritimus SCM1
Length = 303
Score = 39.5 bits (88), Expect = 0.12
Identities = 72/310 (23%), Positives = 131/310 (42%), Gaps = 26/310 (8%)
Query: 20 VTVVGATSEVGQVXXXXXXXXXXITKLVVHDNKEFTPGVTLDL-SQIPSPSRILGLTGED 78
+++VG T VG L+V+ KE G +LD+ S IP+ S+ + G D
Sbjct: 5 ISIVG-TGRVGASIAFLCVSNGLDDVLLVNTTKEKAIGESLDVASAIPANSK-FSIRGTD 62
Query: 79 TLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPI 138
+ + +IIAA +E + IK+I K+ + CP V +V+ P+
Sbjct: 63 DYSELIGSDIVIIAASVGIYTKHRAEN--IDHQVAMIKNIAKKIKKYCPSAIVLLVSNPL 120
Query: 139 NYLIPMTAEIMRNHGVYDEKKLFGI-TEIDAIRSQCLYATENNLKANDCYVP---VIGGH 194
+ L T + G + K+ GI + +D R + Y L V V+G H
Sbjct: 121 DVL---TYFFQKTTG-FSRFKVIGIASSLDTSRFR--YYISETLSVPQSSVSNALVLGEH 174
Query: 195 SDKTIVPLLSQA----KPTVEMKEKDLEEFTIKLRNCDGMITKAKRGCIPNLSVAYSSFL 250
D ++VP+ S P M + + T +RN + K +A + F
Sbjct: 175 GD-SMVPIFSGVSVGDNPLFSMID-SRDTITDNVRNYWRTLRNFKSR--SQFGIAKNVFD 230
Query: 251 FTKSILDALEGS-PAKIHAFVDNNDFGTSYFSSLVNLDKNGVKEMVRYSEFSKFECDLIE 309
+I + E S PA + + ++ + ++ +++NGV E ++ + E ++
Sbjct: 231 VVDAIRNKKEISIPASVVLDGEYDEHDVAMGIPVI-INQNGVSE-IQKIKLDDTESSSLK 288
Query: 310 KSLQQLRKDV 319
KS +++R D+
Sbjct: 289 KSAEKIRSDI 298
>UniRef50_O08349 Cluster: Malate dehydrogenase; n=1; Archaeoglobus
fulgidus|Rep: Malate dehydrogenase - Archaeoglobus
fulgidus
Length = 294
Score = 39.5 bits (88), Expect = 0.12
Identities = 32/120 (26%), Positives = 58/120 (48%), Gaps = 11/120 (9%)
Query: 84 LKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPINYLIP 143
LK S++I+ GL+++P ++ L N+ IK I K+ + P + +VT P++ +
Sbjct: 67 LKGSEIIVVTAGLARKPGMTRLDLAHKNAGIIKDIAKKIVENAPESKILVVTNPMDVM-- 124
Query: 144 MTAEIMRNHGVYDEKKLFGI-TEIDAIR-SQCLY-ATENNLKANDCYVPVIGGHSDKTIV 200
IM ++FG+ ++D+ R + LY A N++ +IG H D V
Sbjct: 125 --TYIMWKESGKPRNEVFGMGNQLDSQRLKERLYNAGARNIRR----AWIIGEHGDSMFV 178
>UniRef50_P0A3M9 Cluster: L-lactate dehydrogenase; n=140;
Bacteria|Rep: L-lactate dehydrogenase - Streptococcus
pneumoniae
Length = 328
Score = 39.5 bits (88), Expect = 0.12
Identities = 52/214 (24%), Positives = 87/214 (40%), Gaps = 23/214 (10%)
Query: 57 GVTLDLSQ---IPSPSRILGLTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQ 113
G LDLS SP +I D + +DL++ G Q+P + L+ N
Sbjct: 49 GDALDLSHALAFTSPKKIYAAQYSDCAD-----ADLVVITAGAPQKPGETRLDLVGKNLA 103
Query: 114 FIKSIISKLGRSCPIPFVGIVTEPINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQC 173
KSI++++ S F GI N + +T + G E+ + T +D+ R +
Sbjct: 104 INKSIVTQVVES---GFKGIFLVAANPVDVLTYSTWKFSGFPKERVIGSGTSLDSARFRQ 160
Query: 174 LYATENNLKANDCYVPVIGGHSDKTI----------VPLLSQAKPTVEMKEKDLEEFTIK 223
A + ++ A + ++G H D V L K T ++E +L E
Sbjct: 161 ALAEKLDVDARSVHAYIMGEHGDSEFAVWSHANIAGVNLEEFLKDTQNVQEAELIELFEG 220
Query: 224 LRNCDGMITKAKRGCIPNLSVAYSSFLFTKSILD 257
+R+ I K ++VA + TK+ILD
Sbjct: 221 VRDAAYTIINKKGATYYGIAVALAR--ITKAILD 252
>UniRef50_P07864 Cluster: L-lactate dehydrogenase C chain; n=371;
Eukaryota|Rep: L-lactate dehydrogenase C chain - Homo
sapiens (Human)
Length = 332
Score = 39.5 bits (88), Expect = 0.12
Identities = 52/208 (25%), Positives = 89/208 (42%), Gaps = 15/208 (7%)
Query: 3 VNRRIISSLFTTTRSYQ--VTVVGATSEVGQVXXXXXXXXXXITKLVVHDNK-EFTPGVT 59
V ++I L + Q +T+VG T VG +L + D + G
Sbjct: 4 VKEQLIEKLIEDDENSQCKITIVG-TGAVGMACAISILLKDLADELALVDVALDKLKGEM 62
Query: 60 LDL---SQIPSPSRILGLTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIK 116
+DL S S S+I +G+D A NS ++I G Q+ + AL+ N +K
Sbjct: 63 MDLQHGSLFFSTSKIT--SGKDYSVSA--NSRIVIVTAGARQQEGETRLALVQRNVAIMK 118
Query: 117 SIISKLGRSCPIPFVGIVTEPINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYA 176
SII + P + +V+ P++ L T + + G+ + + +D+ R + L
Sbjct: 119 SIIPAIVHYSPDCKILVVSNPVDIL---TYIVWKISGLPVTRVIGSGCNLDSARFRYLIG 175
Query: 177 TENNLKANDCYVPVIGGHSDKTIVPLLS 204
+ + C+ +IG H D + VPL S
Sbjct: 176 EKLGVHPTSCHGWIIGEHGDSS-VPLWS 202
>UniRef50_A1U9V0 Cluster: Lactate/malate dehydrogenase; n=6;
Actinomycetales|Rep: Lactate/malate dehydrogenase -
Mycobacterium sp. (strain KMS)
Length = 329
Score = 37.5 bits (83), Expect = 0.47
Identities = 44/188 (23%), Positives = 74/188 (39%), Gaps = 9/188 (4%)
Query: 19 QVTVVGATSEVGQVXXXXXXXXXXITKLVVHD-NKEFTPGVTLDLSQIPSPSRILGLTGE 77
+V+++GA S VG L ++D N LDL+ + G
Sbjct: 20 KVSIIGAGS-VGTAIAYACLIRGSAGTLALYDTNSAKVRAEVLDLNHGSQFVPECRVGGS 78
Query: 78 DTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEP 137
D + S +++ G Q P S L AN +++ +L P V VT P
Sbjct: 79 DDIA-VTAGSAIVVVTAGAKQHPGQSRLDLAAANVAMAQTLTPQLLEHSPDAVVIFVTNP 137
Query: 138 INYLIPMTAEIMRNHGVYDEKKLFGI-TEIDAIRSQCLYATENNLKANDCYVPVIGGHSD 196
++ + + ++ ++FG T +D+ R + L A + + + VIG H D
Sbjct: 138 VDVVTYAASSVVD----AQPGQIFGTGTVLDSSRFRYLVAQRAAIAVGNVHALVIGEHGD 193
Query: 197 KTIVPLLS 204
I PL S
Sbjct: 194 SEI-PLWS 200
>UniRef50_Q8I8U4 Cluster: Lactate dehydrogenase; n=3;
Eimeriorina|Rep: Lactate dehydrogenase - Eimeria tenella
Length = 331
Score = 37.5 bits (83), Expect = 0.47
Identities = 29/126 (23%), Positives = 60/126 (47%), Gaps = 11/126 (8%)
Query: 83 ALKNSDLIIAAGGLSQRP-----DISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEP 137
+L+ +D++I G+++ + S K LL N + ++ + + + + CP FV +T P
Sbjct: 74 SLEGADVVIITAGITKAAGKSDQEWSRKDLLPVNVKILREVGAAIKQFCPHAFVINITNP 133
Query: 138 INYLIPMTAEIMRNHGVYDEKKLFGITEI-DAIRSQCLYATENNLKANDCYVPVIGGHSD 196
++ ++ +R ++ G+ + D+ R + L A + D V+G H D
Sbjct: 134 LDVMV----AALREAAGLPAARVCGMAGVLDSARFRRLLADRLGVSPRDVQAMVLGVHGD 189
Query: 197 KTIVPL 202
+VPL
Sbjct: 190 -NMVPL 194
>UniRef50_Q9P4B6 Cluster: L-lactate dehydrogenase A; n=48; Rhizopus
oryzae|Rep: L-lactate dehydrogenase A - Rhizopus oryzae
(Rhizopus delemar)
Length = 320
Score = 36.3 bits (80), Expect = 1.1
Identities = 38/183 (20%), Positives = 74/183 (40%), Gaps = 8/183 (4%)
Query: 19 QVTVVGATSEVGQVXXXXXXXXXXITKLVVHD-NKEFTPGVTLDLSQIPSPSRILGLTGE 77
+V +VGA + VG T++++ D N + LDL+ S S G
Sbjct: 6 KVAIVGAGA-VGASTAYALMFKNICTEIIIVDVNPDIVQAQVLDLADAASISHTPIRAG- 63
Query: 78 DTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEP 137
+ E A +D+++ G QR L+ N + ++SII + P + +V P
Sbjct: 64 -SAEEA-GQADIVVITAGAKQREGEPRTKLIERNFRVLQSIIGGMQPIRPDAVILVVANP 121
Query: 138 INYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIGGHSDK 197
++ L + + G+ + + T +D R + ++ + V+G H D
Sbjct: 122 VDILTHIAKTL---SGLPPNQVIGSGTYLDTTRLRVHLGDVFDVNPQSVHAFVLGEHGDS 178
Query: 198 TIV 200
++
Sbjct: 179 QMI 181
>UniRef50_A3DCA4 Cluster: L-lactate dehydrogenase precursor; n=2;
Clostridium|Rep: L-lactate dehydrogenase precursor -
Clostridium thermocellum (strain ATCC 27405 / DSM 1237)
Length = 318
Score = 35.9 bits (79), Expect = 1.4
Identities = 40/188 (21%), Positives = 83/188 (44%), Gaps = 10/188 (5%)
Query: 19 QVTVVGATSEVGQVXXXXXXXXXXITKLVVHDN-KEFTPGVTLDLSQ-IPSPSRILGLTG 76
+V ++GA VG +LV+ D KE G +D++ +P ++ G
Sbjct: 9 KVAIIGA-GFVGASAAFTMALRQTANELVLIDVFKEKAIGEAMDINHGLPFMGQMSLYAG 67
Query: 77 EDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTE 136
+ + +K+ D+I+ G +++P + L N K + + + + +V+
Sbjct: 68 DYS---DVKDCDVIVVTAGANRKPGETRLDLAKKNVMIAKEVTQNIMKYYNHGVILVVSN 124
Query: 137 PINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIGGHSD 196
P++ + M I + G+ K + T +D+IR + L + + + + + +IG H D
Sbjct: 125 PVDIITYM---IQKWSGLPVGKVIGSGTVLDSIRFRYLLSEKLGVDVKNVHGYIIGEHGD 181
Query: 197 KTIVPLLS 204
+ PL S
Sbjct: 182 SQL-PLWS 188
>UniRef50_Q27SQ2 Cluster: Aldo/keto reductase; n=1; Euglena
gracilis|Rep: Aldo/keto reductase - Euglena gracilis
Length = 236
Score = 35.9 bits (79), Expect = 1.4
Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 1/67 (1%)
Query: 45 KLVVHDNKEFTPGVTLDLSQIPSPSRILGLTGEDTLERALKNSDLIIAAGGLSQRP-DIS 103
+L V+DN+ PGV LD +++P+ SR LTG + + + L+ L I RP +
Sbjct: 95 RLFVYDNRPDVPGVELDKTKLPNHSRANVLTGCEGILQRLQTDYLDILYLHWPARPIPVF 154
Query: 104 EKALLTA 110
KA+ TA
Sbjct: 155 GKAMYTA 161
>UniRef50_Q4UJ29 Cluster: L-lactate dehydrogenase, putative; n=2;
Theileria|Rep: L-lactate dehydrogenase, putative -
Theileria annulata
Length = 367
Score = 35.9 bits (79), Expect = 1.4
Identities = 22/101 (21%), Positives = 52/101 (51%), Gaps = 6/101 (5%)
Query: 107 LLTANSQFIKSIISKLGRSCPIPFVGIVTEPINYLIPMTAEIMRNHGVYDEKKLFGITE- 165
L+ NS+ I+ + + + P FV ++T P++ ++ + ++ + + + G+
Sbjct: 146 LVGYNSKIIRDVGENIKKYAPEAFVIVITNPMDVMVHLMLKVTG----FPKNMVVGMGGL 201
Query: 166 IDAIRSQCLYATENNLKANDCYVPVIGGHSDKTIVPLLSQA 206
+D+ R C A + + + VIG H D +++PL+S++
Sbjct: 202 LDSSRMNCYIAEKLGVNPKYVHGSVIGAHGD-SMIPLVSRS 241
>UniRef50_P61973 Cluster: Malate dehydrogenase; n=43; Bacteria|Rep:
Malate dehydrogenase - Bdellovibrio bacteriovorus
Length = 335
Score = 35.9 bits (79), Expect = 1.4
Identities = 37/142 (26%), Positives = 59/142 (41%), Gaps = 5/142 (3%)
Query: 57 GVTLDLSQIPSPS-RILGLTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFI 115
GV ++L P + TG+ + A K++D+ + G + P + K LLTAN Q
Sbjct: 54 GVMMELEDCAFPLLHSMIATGDPAV--AFKDADVALLVGARPRGPGMERKDLLTANGQIF 111
Query: 116 KSIISKLGR-SCPIPFVGIVTEPINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCL 174
+G+ + P V +V P N + + HG K + +D R+
Sbjct: 112 TVQGEAIGKYANPNVKVLVVGNPANTNAYIAMKSAMKHGRVKAKNFTAMLRLDHNRALSQ 171
Query: 175 YATENNLK-ANDCYVPVIGGHS 195
AT+ A+ V V G HS
Sbjct: 172 LATKTGKPVASFKKVAVWGNHS 193
>UniRef50_A5Z9B1 Cluster: Putative uncharacterized protein; n=1;
Eubacterium ventriosum ATCC 27560|Rep: Putative
uncharacterized protein - Eubacterium ventriosum ATCC
27560
Length = 312
Score = 35.5 bits (78), Expect = 1.9
Identities = 32/140 (22%), Positives = 63/140 (45%), Gaps = 8/140 (5%)
Query: 85 KNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPINYLIPM 144
K++D+I+ + G+ + P + +L + + ++ I+S L + I GI+ I +
Sbjct: 71 KDADIIVISAGVPRLPGQTRLDVLDGSVECVRDIVSNLNK---IEIKGIII-TITNPADI 126
Query: 145 TAEIMRNHGVYDEKKLFGI-TEIDAIRSQCLYATENNLKANDCYVPVIGGHSDKTIVP-- 201
A+ +R + ++F T +D R + A N+ +G H D ++VP
Sbjct: 127 IADFVRKATGLPKNRVFSTGTSLDTARMRRTVADLCNIAPQSVIGFAMGEHGDSSMVPFS 186
Query: 202 -LLSQAKPTVEMKEKDLEEF 220
L K +KE++ E F
Sbjct: 187 NLTIFGKNYKHLKEENPERF 206
>UniRef50_A4M499 Cluster: Redoxin domain protein; n=3;
Desulfuromonadales|Rep: Redoxin domain protein -
Geobacter bemidjiensis Bem
Length = 158
Score = 35.5 bits (78), Expect = 1.9
Identities = 18/63 (28%), Positives = 31/63 (49%)
Query: 137 PINYLIPMTAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIGGHSD 196
P L A +M+ +G Y EK+ +G T I +IRS + + + + + +P H D
Sbjct: 86 PFTLLSDPDASVMKAYGAYGEKQQYGKTTIGSIRSTVVISPDGMVIKHWPKIPKASEHPD 145
Query: 197 KTI 199
K +
Sbjct: 146 KVL 148
>UniRef50_A4AQ95 Cluster: Putative uncharacterized protein; n=2;
Bacteroidetes|Rep: Putative uncharacterized protein -
Flavobacteriales bacterium HTCC2170
Length = 373
Score = 35.5 bits (78), Expect = 1.9
Identities = 19/53 (35%), Positives = 29/53 (54%)
Query: 277 TSYFSSLVNLDKNGVKEMVRYSEFSKFECDLIEKSLQQLRKDVSKGRKILELA 329
TS F L +D N V++ + E+ +F DLI K + +L K V + K+L A
Sbjct: 191 TSDFKELTGIDINEVEDPSQIQEWKQFRYDLITKMVNRLSKVVHEKGKVLNAA 243
>UniRef50_A3ZZ88 Cluster: L-lactate/malate dehydrogenase; n=1;
Blastopirellula marina DSM 3645|Rep: L-lactate/malate
dehydrogenase - Blastopirellula marina DSM 3645
Length = 308
Score = 35.5 bits (78), Expect = 1.9
Identities = 52/236 (22%), Positives = 101/236 (42%), Gaps = 16/236 (6%)
Query: 87 SDLIIAAGGL-SQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPINYLIPMT 145
SD+I+ S+ D+ N + ++ I L + P +VT P++ MT
Sbjct: 69 SDVILYCDAAQSKTSDVDRYCAARGNLERLRERIPILAAASPQAICVMVTNPVDV---MT 125
Query: 146 AEIMRNHGVYDEKKLFGI-TEIDAIRSQCLYATENNLKANDCYVPVIGGHSDKTIVPLLS 204
++ G + ++++FG+ T +D R + L + ++ A+D VIG H + + S
Sbjct: 126 WFALQLSG-FPQERVFGVGTLLDTARLRRLLSERWSVHASDVRAYVIGEHGEDQVASFSS 184
Query: 205 QAKPTVEMK-EKDLEEFTIKLRNCDGMITKAKRGCIPNLSVAYSSFLFTKSIL-DALEGS 262
+ MK DL + G I + RG N +A ++ + +SI + +
Sbjct: 185 ASLGGEAMKPSDDLASLARQAAESAGKIYRT-RG-FTNYGIAGATMMILESIRNNRRRTA 242
Query: 263 PAKIHAFVDNNDFGTS--YFSSLVNLDKNGVKEMVRYSEFSKFECDLIEKSLQQLR 316
P + NN G S S + + G++ ++R E ++ E + Q++R
Sbjct: 243 PVSMRI---NNYHGVSDVCLSLPAVIGRRGIERVLR-PELNEAEQATFHRGAQRIR 294
>UniRef50_Q75DD3 Cluster: ABR094Wp; n=1; Eremothecium gossypii|Rep:
ABR094Wp - Ashbya gossypii (Yeast) (Eremothecium
gossypii)
Length = 359
Score = 35.1 bits (77), Expect = 2.5
Identities = 15/29 (51%), Positives = 22/29 (75%)
Query: 71 ILGLTGEDTLERALKNSDLIIAAGGLSQR 99
+LG++ D LERALKN L++ GGLS++
Sbjct: 293 VLGVSTMDELERALKNYHLVLEQGGLSEK 321
>UniRef50_Q30PU9 Cluster: Type I secretion membrane fusion protein,
HlyD; n=1; Thiomicrospira denitrificans ATCC 33889|Rep:
Type I secretion membrane fusion protein, HlyD -
Thiomicrospira denitrificans (strain ATCC 33889 / DSM
1351)
Length = 431
Score = 34.7 bits (76), Expect = 3.3
Identities = 35/125 (28%), Positives = 62/125 (49%), Gaps = 13/125 (10%)
Query: 176 ATENNLKANDCYVPVIG---GHSDKTIVPLLSQAKPTVEMKEKDLEEFTI-KLRNCDGMI 231
ATE+ L+ P+ G G T ++S AKP +E+ +D + + +++ D I
Sbjct: 271 ATEDTLERTAIVAPIDGIVVGFEIHTEGGVVSPAKPILEIVPQDSKLIVVAQVQITD--I 328
Query: 232 TKAKRGCIPNLSVAYSSFLFTKSILDALEGSPAKIHA--FVDNNDFGTSYFSSLVNLDKN 289
K + G I + + +S+F +S +EG + A F+ N D T Y+S+ + + K
Sbjct: 329 DKVQVGLIAD--IRFSAFDLRQS--HVVEGKVVHVSADSFI-NQDGKTQYYSAKIEVTKE 383
Query: 290 GVKEM 294
GVK +
Sbjct: 384 GVKSL 388
>UniRef50_Q380Z7 Cluster: Putative uncharacterized protein; n=1;
Trypanosoma brucei|Rep: Putative uncharacterized protein
- Trypanosoma brucei
Length = 2059
Score = 34.7 bits (76), Expect = 3.3
Identities = 39/153 (25%), Positives = 66/153 (43%), Gaps = 18/153 (11%)
Query: 63 SQIPSP-----SRILGLTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKS 117
S++P P R+L L G++ +ER L A+G + + P IS + + + +
Sbjct: 1275 SRLPKPLANGAGRLLPLAGDEQIERLPGVGGLGSASGAVQEEPAISCQQVPEKPTPRAEG 1334
Query: 118 IISKLGRSCPIPFVGIVTEPINYLIPMTAE------IMRNHGVYDEKKLFGITEIDAIRS 171
+ +L C VG+V E + P+ E +++ H +Y E ++ +
Sbjct: 1335 VKLELTMPCSPGDVGVVPELQHLATPIIPEERVGLSLIKEHAMYSEPGERPALYLEGVEP 1394
Query: 172 QCLYATENNLKAN----DCYVPVIGGHSDKTIV 200
ATE NL N + P GGHS + IV
Sbjct: 1395 S---ATELNLDINEPVGEFARPDNGGHSAEEIV 1424
>UniRef50_Q4L941 Cluster: L-lactate dehydrogenase; n=1;
Staphylococcus haemolyticus JCSC1435|Rep: L-lactate
dehydrogenase - Staphylococcus haemolyticus (strain
JCSC1435)
Length = 318
Score = 34.7 bits (76), Expect = 3.3
Identities = 25/116 (21%), Positives = 49/116 (42%), Gaps = 5/116 (4%)
Query: 85 KNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPINYLIPM 144
K++D+++ + LL N +I ++ S F G P N + +
Sbjct: 70 KDADIVVICASAKLAKGETRLKLLEDNVDIFVPMIQRIVDS---GFDGYFVLPSNP-VDI 125
Query: 145 TAEIMRNHGVYDEKKLFGI-TEIDAIRSQCLYATENNLKANDCYVPVIGGHSDKTI 199
+ +++ + + K+ G T +D R Q + E ++ N Y P+IG H D +
Sbjct: 126 MSYVVKRVSNFPKNKIIGSGTSLDTARFQFFLSREFDVAPNQVYAPIIGEHGDSQV 181
>UniRef50_UPI000049A3E4 Cluster: hypothetical protein 62.t00026;
n=1; Entamoeba histolytica HM-1:IMSS|Rep: hypothetical
protein 62.t00026 - Entamoeba histolytica HM-1:IMSS
Length = 985
Score = 34.3 bits (75), Expect = 4.4
Identities = 24/74 (32%), Positives = 39/74 (52%), Gaps = 7/74 (9%)
Query: 221 TIKLRNCDGMITKAK-RGCIPNLSVAYSSFLFTKSILDALEGSPAKIHAFVDNNDFGTSY 279
T+KLRNC G I K +G ++ V Y++ L + +E +I F++ + G SY
Sbjct: 439 TLKLRNCYGEIKKVCCKGDNKSIVVCYTNSL------EEIEIEGYRIIQFIEKSVVGVSY 492
Query: 280 FSSLVNLDKNGVKE 293
L+ +DKN K+
Sbjct: 493 DKELMIIDKNEYKK 506
>UniRef50_Q8UYV8 Cluster: Polyprotein; n=24; Strawberry mottle
virus|Rep: Polyprotein - Strawberry mottle virus
Length = 1452
Score = 34.3 bits (75), Expect = 4.4
Identities = 27/91 (29%), Positives = 43/91 (47%), Gaps = 6/91 (6%)
Query: 239 IPNLSVAYS---SFLFTKSILDALEGSPAKIHAFVDNNDFGTSYFSSLVNLDKNGVKEMV 295
+PN YS S + + +DA+E P +H N T + VN D + K V
Sbjct: 1284 VPNQYQPYSFNPSGGYVRPEMDAMEQKPHLLHIQHTNFQSNTHLYDRCVNYDHS--KGPV 1341
Query: 296 RYSEFSKFECDLIEKSLQQL-RKDVSKGRKI 325
R+S+ F+ LI +++Q R + KG +I
Sbjct: 1342 RFSDCGGFDPSLINPAVEQSDRGSLQKGEEI 1372
>UniRef50_Q1IRL5 Cluster: L-lactate dehydrogenase; n=6;
Bacteria|Rep: L-lactate dehydrogenase - Acidobacteria
bacterium (strain Ellin345)
Length = 321
Score = 34.3 bits (75), Expect = 4.4
Identities = 28/122 (22%), Positives = 55/122 (45%), Gaps = 4/122 (3%)
Query: 85 KNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVGIVTEPINYLIPM 144
+ + + + G +QRP + LL N + I+ ++ + P + I T P++ +
Sbjct: 76 RGAAVTVITAGAAQRPGETRLQLLDRNLAIFQQIVPEVVKHNPDGLLLIATNPVDIISYA 135
Query: 145 TAEIMRNHGVYDEKKLFGITEIDAIRSQCLYATENNLKANDCYVPVIGGHSDKTIVPLLS 204
+ +I G+ + L T +D R + L ++ A + ++G H D T VP+ S
Sbjct: 136 SYKI---SGLPAHRVLGSGTILDTARFRYLLGQHFSVDARSVHGLILGEHGD-TEVPIWS 191
Query: 205 QA 206
A
Sbjct: 192 LA 193
>UniRef50_A0YP26 Cluster: Sensor protein; n=1; Lyngbya sp. PCC
8106|Rep: Sensor protein - Lyngbya sp. PCC 8106
Length = 810
Score = 34.3 bits (75), Expect = 4.4
Identities = 21/72 (29%), Positives = 36/72 (50%), Gaps = 3/72 (4%)
Query: 259 LEGSPAKIHAFVDNNDFGTSYFS-SLVNLDKNGVKEMVRYSEF--SKFECDLIEKSLQQL 315
L SP I+ + D+G +Y S ++ ++ E V S+F + D +EK+ QL
Sbjct: 326 LSSSPGAIYTSIPTGDYGATYMSQTIYSITGYQAWEFVEKSQFWAERVHPDDLEKAFNQL 385
Query: 316 RKDVSKGRKILE 327
+ + G +ILE
Sbjct: 386 SQVLETGTEILE 397
>UniRef50_Q8TZ24 Cluster: Shikimate dehydrogenase; n=11;
Archaea|Rep: Shikimate dehydrogenase - Methanopyrus
kandleri
Length = 290
Score = 33.9 bits (74), Expect = 5.8
Identities = 18/54 (33%), Positives = 32/54 (59%), Gaps = 1/54 (1%)
Query: 69 SRILGLTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKL 122
+R +GL G D +ER L+++DL++ A + P+ E L+TA+ I++ L
Sbjct: 181 ARAIGLDG-DEIERELRDADLLVDATPVGMYPNEDEPPLVTADQMHEDLIVNDL 233
>UniRef50_Q7XB94 Cluster: Disease relative signal 1; n=2; Oryza
sativa|Rep: Disease relative signal 1 - Oryza sativa
subsp. japonica (Rice)
Length = 542
Score = 33.5 bits (73), Expect = 7.7
Identities = 19/65 (29%), Positives = 29/65 (44%), Gaps = 1/65 (1%)
Query: 165 EIDAIRSQCLYATENNLKANDCYV-PVIGGHSDKTIVPLLSQAKPTVEMKEKDLEEFTIK 223
E+ +C+ L A + + P + +K PL S K +VE + KDL +K
Sbjct: 254 EVRFFIEKCIAKASQRLSAQELLMDPFLRDDGEKIFYPLQSNTKASVESQMKDLNTIFLK 313
Query: 224 LRNCD 228
LR D
Sbjct: 314 LRIAD 318
>UniRef50_Q55AK2 Cluster: AN1-type Zn finger-containing protein;
n=2; Dictyostelium discoideum|Rep: AN1-type Zn
finger-containing protein - Dictyostelium discoideum AX4
Length = 1024
Score = 33.5 bits (73), Expect = 7.7
Identities = 37/183 (20%), Positives = 69/183 (37%), Gaps = 6/183 (3%)
Query: 13 TTTRSYQVTVVGATSEVGQVXXXXXXXXXXITKLVVHDNKEFTPGVTLDLSQIPSPSRIL 72
TT + V ++ + +V + KL+ + N G ++ ++I P+RIL
Sbjct: 265 TTVVEFIVQLIKSGKKVLACGPSNLSVDNMLEKLLEYSNSSSCNGFLINATRIGHPTRIL 324
Query: 73 GLTGEDTLERALKNSDLIIAAGGLSQRPDISEKALLTANSQFIKSIISKLGRSCPIPFVG 132
+ TL+ KNS+ G+ K LL + +I + I
Sbjct: 325 PQLLKHTLDHKTKNSEGGQIIKGIKDEIKSLSKQLLKVKQHSERRVIQSSIKELRIDLKN 384
Query: 133 IVTEPINYLIPMTAEIMRNHGVYDEKKLFGITEID-AIRSQCLYATENNLKANDCYVPVI 191
I +I + I+ + + L GI D + +C A E + C++P+
Sbjct: 385 REKSLIQQVINDSNVILSTNTGASDSSLKGIDNFDWVVIDECAQALEAS-----CWIPIQ 439
Query: 192 GGH 194
G+
Sbjct: 440 KGN 442
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.135 0.377
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 327,931,136
Number of Sequences: 1657284
Number of extensions: 13117027
Number of successful extensions: 33500
Number of sequences better than 10.0: 113
Number of HSP's better than 10.0 without gapping: 58
Number of HSP's successfully gapped in prelim test: 55
Number of HSP's that attempted gapping in prelim test: 33357
Number of HSP's gapped (non-prelim): 123
length of query: 329
length of database: 575,637,011
effective HSP length: 101
effective length of query: 228
effective length of database: 408,251,327
effective search space: 93081302556
effective search space used: 93081302556
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
S2: 73 (33.5 bits)
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