Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA000973-TA|BGIBMGA000973-PA|IPR000719|Protein kinase,
IPR000980|SH2 motif, IPR001245|Tyrosine protein kinase
(159 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P08630 Cluster: Tyrosine-protein kinase Btk29A; n=10; E... 204 5e-52
UniRef50_Q06187 Cluster: Tyrosine-protein kinase BTK; n=54; Gnat... 126 2e-28
UniRef50_UPI00004D86FC Cluster: Tyrosine-protein kinase Tec (EC ... 125 4e-28
UniRef50_P42680 Cluster: Tyrosine-protein kinase Tec; n=86; Coel... 118 8e-26
UniRef50_Q7YZX2 Cluster: Bruton's tyrosine kinase-like protein; ... 117 1e-25
UniRef50_Q08881 Cluster: Tyrosine-protein kinase ITK/TSK; n=18; ... 115 6e-25
UniRef50_UPI0000ECD739 Cluster: Cytoplasmic tyrosine-protein kin... 110 2e-23
UniRef50_P51813 Cluster: Cytoplasmic tyrosine-protein kinase BMX... 107 2e-22
UniRef50_Q60I21 Cluster: TEC family protein tyrosine kinase; n=1... 103 2e-21
UniRef50_UPI0000F1FB23 Cluster: PREDICTED: similar to tyrosine p... 91 1e-17
UniRef50_Q9NH62 Cluster: Tyrosine kinase 5; n=2; Schistosoma man... 90 2e-17
UniRef50_P51451 Cluster: Tyrosine-protein kinase BLK; n=5; Eutel... 83 2e-15
UniRef50_Q4RNX3 Cluster: Chromosome 10 SCAF15009, whole genome s... 81 9e-15
UniRef50_P00528 Cluster: Tyrosine-protein kinase Src64B; n=6; En... 81 1e-14
UniRef50_P08631 Cluster: Tyrosine-protein kinase HCK; n=32; Eute... 80 2e-14
UniRef50_Q70DV1 Cluster: Src tyrosine kinase; n=1; Schistosoma m... 79 6e-14
UniRef50_Q8T6F8 Cluster: SRC-1; n=3; Caenorhabditis|Rep: SRC-1 -... 77 2e-13
UniRef50_P42686 Cluster: Tyrosine-protein kinase isoform SRK1; n... 77 2e-13
UniRef50_P42685 Cluster: Tyrosine-protein kinase FRK; n=27; Fung... 76 3e-13
UniRef50_Q66I04 Cluster: Zgc:92124; n=1; Danio rerio|Rep: Zgc:92... 75 7e-13
UniRef50_P07947 Cluster: Proto-oncogene tyrosine-protein kinase ... 75 7e-13
UniRef50_Q6R1Y3 Cluster: Src family kinase; n=6; Fungi/Metazoa g... 73 3e-12
UniRef50_UPI0000E4736E Cluster: PREDICTED: similar to src-family... 70 3e-11
UniRef50_Q4RL31 Cluster: Chromosome undetermined SCAF15024, whol... 69 5e-11
UniRef50_P42684 Cluster: Tyrosine-protein kinase ABL2; n=38; Eut... 69 5e-11
UniRef50_UPI00015B4B0F Cluster: PREDICTED: similar to proto-onco... 69 6e-11
UniRef50_P00519 Cluster: Proto-oncogene tyrosine-protein kinase ... 68 9e-11
UniRef50_P00521 Cluster: Tyrosine-protein kinase transforming pr... 68 1e-10
UniRef50_P10447 Cluster: Tyrosine-protein kinase transforming pr... 68 1e-10
UniRef50_UPI0000519AF4 Cluster: PREDICTED: similar to Abl tyrosi... 64 1e-09
UniRef50_UPI0000F1EB7D Cluster: PREDICTED: hypothetical protein;... 60 3e-08
UniRef50_P00522 Cluster: Tyrosine-protein kinase Abl; n=5; Eumet... 57 2e-07
UniRef50_Q13882 Cluster: Tyrosine-protein kinase 6; n=11; Mammal... 55 6e-07
UniRef50_Q4TEC1 Cluster: Chromosome undetermined SCAF5507, whole... 53 3e-06
UniRef50_Q4RNL0 Cluster: Chromosome 21 SCAF15012, whole genome s... 52 8e-06
UniRef50_Q17MF5 Cluster: Tyrosine-protein kinase; n=2; Culicidae... 50 2e-05
UniRef50_P03949 Cluster: Tyrosine-protein kinase abl-1; n=5; Cae... 50 2e-05
UniRef50_UPI00005A5E2E Cluster: PREDICTED: similar to Bruton aga... 49 4e-05
UniRef50_Q0PDJ5 Cluster: Protein tyrosine kinase CSK; n=1; Monos... 48 7e-05
UniRef50_Q9H3Y6 Cluster: Tyrosine-protein kinase Srms; n=17; Amn... 47 2e-04
UniRef50_Q9Y1Z0 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 46 4e-04
UniRef50_O77132 Cluster: Non-receptor protein-tyrosine kinase CS... 44 0.002
UniRef50_A2RQD7 Cluster: Bcr-abl1 e19a2 chimeric protein; n=2; H... 42 0.005
UniRef50_A2RQD6 Cluster: Bcr-abl1 e6a2 chimeric protein; n=10; E... 42 0.005
UniRef50_A2RQD3 Cluster: Bcr-abl1 e13a3 chimeric protein; n=21; ... 42 0.005
UniRef50_Q5BXT3 Cluster: SJCHGC03955 protein; n=1; Schistosoma j... 42 0.006
UniRef50_Q613B1 Cluster: Putative uncharacterized protein CBG164... 42 0.009
UniRef50_O77440 Cluster: Protein-tyrosine kinase HTK98; n=1; Hyd... 41 0.011
UniRef50_Q70W05 Cluster: Src protein; n=1; Ciona intestinalis|Re... 40 0.020
UniRef50_Q20933 Cluster: Putative uncharacterized protein; n=1; ... 40 0.020
UniRef50_O01798 Cluster: Defective spermatogenesis protein 8; n=... 40 0.020
UniRef50_P41240 Cluster: Tyrosine-protein kinase CSK; n=21; Deut... 40 0.020
UniRef50_Q7T0U4 Cluster: MGC68984 protein; n=2; Xenopus|Rep: MGC... 40 0.034
UniRef50_Q08BY6 Cluster: Zgc:153964; n=3; Danio rerio|Rep: Zgc:1... 39 0.045
UniRef50_Q9BL77 Cluster: C-terminal src kinase protein 1; n=2; C... 39 0.045
UniRef50_Q6NP28 Cluster: LP09923p; n=6; Endopterygota|Rep: LP099... 38 0.079
UniRef50_Q3ZB94 Cluster: Zgc:113360; n=3; Clupeocephala|Rep: Zgc... 38 0.11
UniRef50_Q13239 Cluster: SRC-like-adapter; n=26; Euteleostomi|Re... 38 0.11
UniRef50_Q7T6Y2 Cluster: Putative serine/threonine-protein kinas... 38 0.14
UniRef50_Q07407 Cluster: Fibroblast growth factor receptor homol... 38 0.14
UniRef50_UPI0000E49A5C Cluster: PREDICTED: similar to TEK tyrosi... 37 0.24
UniRef50_Q7T6X2 Cluster: Putative serine/threonine-protein kinas... 37 0.24
UniRef50_UPI0000F2B3BE Cluster: PREDICTED: similar to Src-like-a... 36 0.32
UniRef50_Q9Y1X9 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 36 0.32
UniRef50_UPI0000D5603D Cluster: PREDICTED: similar to Insulin re... 36 0.42
UniRef50_Q5DM52 Cluster: Receptor tyrosine kinase Torso-like pro... 36 0.42
UniRef50_P42687 Cluster: Tyrosine-protein kinase SPK-1; n=1; Gir... 36 0.42
UniRef50_P16591 Cluster: Proto-oncogene tyrosine-protein kinase ... 36 0.42
UniRef50_Q4SR72 Cluster: Chromosome 11 SCAF14528, whole genome s... 36 0.56
UniRef50_UPI0000E47549 Cluster: PREDICTED: similar to Cek8; n=2;... 35 0.74
UniRef50_Q1HTP2 Cluster: Tyrosine-protein kinase receptor; n=4; ... 35 0.74
UniRef50_P53356 Cluster: Tyrosine-protein kinase HTK16; n=1; Hyd... 35 0.74
UniRef50_UPI0000DB7735 Cluster: PREDICTED: similar to Insulin re... 34 1.3
UniRef50_Q9XXE5 Cluster: Putative uncharacterized protein; n=1; ... 34 1.3
UniRef50_Q16YD9 Cluster: Kinase suppressor of ras; n=1; Aedes ae... 34 1.3
UniRef50_P18106 Cluster: Tyrosine-protein kinase Fps85D; n=12; E... 34 1.3
UniRef50_UPI0000F1F44E Cluster: PREDICTED: similar to Src-like-a... 34 1.7
UniRef50_UPI0000D55B96 Cluster: PREDICTED: similar to Tyrosine-p... 34 1.7
UniRef50_Q7PXM5 Cluster: ENSANGP00000009647; n=2; Eumetazoa|Rep:... 33 2.3
UniRef50_Q17JW1 Cluster: Tyrosine protein kinase; n=2; Culicidae... 33 2.3
UniRef50_UPI00015B47C1 Cluster: PREDICTED: similar to gag-pol po... 33 3.0
UniRef50_UPI0000E47068 Cluster: PREDICTED: similar to tyrosine p... 33 3.0
UniRef50_Q45FX5 Cluster: Protein vav-1; n=4; Caenorhabditis|Rep:... 33 3.0
UniRef50_Q9UF33 Cluster: Ephrin type-A receptor 6 precursor; n=5... 33 3.0
UniRef50_UPI0000D577C3 Cluster: PREDICTED: similar to CG8874-PB,... 33 3.9
UniRef50_A5AKP8 Cluster: Putative uncharacterized protein; n=1; ... 33 3.9
UniRef50_A1RYL7 Cluster: Sec-independent translocation protein m... 33 3.9
UniRef50_Q6J4P8 Cluster: Insulin-like receptor; n=2; Apis mellif... 32 5.2
UniRef50_UPI000069DB6A Cluster: Ephrin type-A receptor 6 precurs... 32 6.9
UniRef50_P43405 Cluster: Tyrosine-protein kinase SYK; n=23; Ther... 32 6.9
UniRef50_Q7Z1L9 Cluster: Neurite outgrowth regulated kinase; n=1... 31 9.1
UniRef50_A3EXK5 Cluster: Fibroblast growth factor receptor b; n=... 31 9.1
UniRef50_Q07292 Cluster: Raf homolog serine/threonine-protein ki... 31 9.1
>UniRef50_P08630 Cluster: Tyrosine-protein kinase Btk29A; n=10;
Endopterygota|Rep: Tyrosine-protein kinase Btk29A -
Drosophila melanogaster (Fruit fly)
Length = 786
Score = 204 bits (499), Expect = 5e-52
Identities = 102/164 (62%), Positives = 116/164 (70%), Gaps = 21/164 (12%)
Query: 1 MSRQRAESLLKREDKEG---------------------NHQQTKHYHIKQNSRGEFYLSD 39
MSRQRAESLLK+ DKEG KHYHIKQN+R E+YLS+
Sbjct: 415 MSRQRAESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSE 474
Query: 40 KHCCASIPELINYHKHNSGGLCSRLKATPCDRPAPPTAGLSHDKWEIDPSELVLMEVLGA 99
KHCC +IP+LINYH+HNSGGL RLK++PCDRP PPTAGLSHDKWEI P EL+LME LG+
Sbjct: 475 KHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGS 534
Query: 100 GQFXXXXXXXXXXXIDTAVKMMKEGTMSEDDFIDEAKVMTSVYY 143
GQF IDTAVKMMKEGTMSEDDFI+EAKVMT + +
Sbjct: 535 GQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQH 578
>UniRef50_Q06187 Cluster: Tyrosine-protein kinase BTK; n=54;
Gnathostomata|Rep: Tyrosine-protein kinase BTK - Homo
sapiens (Human)
Length = 659
Score = 126 bits (304), Expect = 2e-28
Identities = 58/121 (47%), Positives = 82/121 (67%), Gaps = 2/121 (1%)
Query: 23 KHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLK--ATPCDRPAPPTAGLS 80
+HY + + ++YL++KH ++IPELINYH+HNS GL SRLK + ++ AP TAGL
Sbjct: 332 RHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLG 391
Query: 81 HDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMSEDDFIDEAKVMTS 140
+ WEIDP +L ++ LG GQF D A+KM+KEG+MSED+FI+EAKVM +
Sbjct: 392 YGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMN 451
Query: 141 V 141
+
Sbjct: 452 L 452
>UniRef50_UPI00004D86FC Cluster: Tyrosine-protein kinase Tec (EC
2.7.10.2).; n=1; Xenopus tropicalis|Rep:
Tyrosine-protein kinase Tec (EC 2.7.10.2). - Xenopus
tropicalis
Length = 647
Score = 125 bits (302), Expect = 4e-28
Identities = 59/127 (46%), Positives = 84/127 (66%), Gaps = 3/127 (2%)
Query: 23 KHYHIKQNSRGE-FYLSDKHCCASIPELINYHKHNSGGLCSRLKATPC--DRPAPPTAGL 79
+HYHIK+ + +YL++KH +IPE+I YHKHN+ GL +RL+ C ++ AP TAG
Sbjct: 341 RHYHIKETQYPKKYYLAEKHVFNTIPEMIEYHKHNAAGLVTRLRYPVCSKNKSAPTTAGF 400
Query: 80 SHDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMSEDDFIDEAKVMT 139
S+DKWEI+PSEL M+ LG+G F A+K ++EG MSE+DFI+EAKVM
Sbjct: 401 SYDKWEINPSELTFMKELGSGLFGVVRLGKWRAQYKVAIKAIREGAMSEEDFIEEAKVMM 460
Query: 140 SVYYLSI 146
+ +L +
Sbjct: 461 KLTHLKL 467
>UniRef50_P42680 Cluster: Tyrosine-protein kinase Tec; n=86;
Coelomata|Rep: Tyrosine-protein kinase Tec - Homo
sapiens (Human)
Length = 631
Score = 118 bits (283), Expect = 8e-26
Identities = 56/120 (46%), Positives = 78/120 (65%), Gaps = 4/120 (3%)
Query: 23 KHYHIKQNSRG--EFYLSDKHCCASIPELINYHKHNSGGLCSRLK--ATPCDRPAPPTAG 78
+HYHIK+ + ++YL++KH SIPE+I YHKHN+ GL +RL+ + + AP TAG
Sbjct: 298 RHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAG 357
Query: 79 LSHDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMSEDDFIDEAKVM 138
S++KWEI+PSEL M LG+G F A+K ++EG M E+DFI+EAKVM
Sbjct: 358 FSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVM 417
>UniRef50_Q7YZX2 Cluster: Bruton's tyrosine kinase-like protein;
n=1; Suberites domuncula|Rep: Bruton's tyrosine
kinase-like protein - Suberites domuncula (Sponge)
Length = 700
Score = 117 bits (281), Expect = 1e-25
Identities = 69/158 (43%), Positives = 91/158 (57%), Gaps = 20/158 (12%)
Query: 1 MSRQRAESLLKREDKEGN-----------------HQ-QTKHYHIKQNSRGEFYLSDKHC 42
+SR RAE++LK E +EG H+ Q +HYHIK + ++++S+KH
Sbjct: 323 LSRTRAENILKGEGREGGFVVRNSSRENMYTLSICHEGQVRHYHIKLDESNKYFISEKHR 382
Query: 43 CASIPELINYHKHNSGGLCSRLKATPCD-RPAPPTAG-LSHDKWEIDPSELVLMEVLGAG 100
SI ELI YHK N GGL +RL+ P P P + G L + WEID L L + LG+G
Sbjct: 383 FPSIKELIEYHKLNGGGLVTRLRKPPVQLAPNPQSLGPLFDEAWEIDKVSLSLGKELGSG 442
Query: 101 QFXXXXXXXXXXXIDTAVKMMKEGTMSEDDFIDEAKVM 138
QF ID A+KMM+EG M+EDDFI+EAKVM
Sbjct: 443 QFGRVVSGKWKGKIDVAIKMMREGAMNEDDFIEEAKVM 480
>UniRef50_Q08881 Cluster: Tyrosine-protein kinase ITK/TSK; n=18;
Euteleostomi|Rep: Tyrosine-protein kinase ITK/TSK - Homo
sapiens (Human)
Length = 620
Score = 115 bits (276), Expect = 6e-25
Identities = 57/125 (45%), Positives = 80/125 (64%), Gaps = 4/125 (3%)
Query: 18 NHQQTKHYHIKQNSRG--EFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPC--DRPA 73
N+ KHYHIK+ + +Y+++K+ SIP LINYH+HN GGL +RL+ C + A
Sbjct: 286 NNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKA 345
Query: 74 PPTAGLSHDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMSEDDFID 133
P TAGL + KW IDPSEL ++ +G+GQF A+K ++EG MSE+DFI+
Sbjct: 346 PVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIE 405
Query: 134 EAKVM 138
EA+VM
Sbjct: 406 EAEVM 410
>UniRef50_UPI0000ECD739 Cluster: Cytoplasmic tyrosine-protein kinase
BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in
chromosome X protein) (Epithelial and endothelial
tyrosine kinase) (ETK) (NTK38).; n=2; Gallus gallus|Rep:
Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)
(Bone marrow tyrosine kinase gene in chromosome X
protein) (Epithelial and endothelial tyrosine kinase)
(ETK) (NTK38). - Gallus gallus
Length = 633
Score = 110 bits (264), Expect = 2e-23
Identities = 52/128 (40%), Positives = 77/128 (60%), Gaps = 5/128 (3%)
Query: 13 EDKEGNHQQTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDR- 71
E+K+G KHYH+ + ++YL++ HC +IP+LINYH+HNS G+ RL+ +
Sbjct: 295 ENKKGT---VKHYHVHKTPENKYYLTENHCFETIPKLINYHQHNSAGMVPRLRHVVSTQI 351
Query: 72 -PAPPTAGLSHDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMSEDD 130
P TA L + WE+ E+V + LG+GQF D AVKM+KEG +SED+
Sbjct: 352 NKVPATASLGNGIWELKREEIVPLRELGSGQFGAVHLGKWKGLYDVAVKMIKEGVVSEDE 411
Query: 131 FIDEAKVM 138
F++EA+ M
Sbjct: 412 FVEEAQTM 419
>UniRef50_P51813 Cluster: Cytoplasmic tyrosine-protein kinase BMX;
n=36; Euteleostomi|Rep: Cytoplasmic tyrosine-protein
kinase BMX - Homo sapiens (Human)
Length = 675
Score = 107 bits (256), Expect = 2e-22
Identities = 52/128 (40%), Positives = 79/128 (61%), Gaps = 7/128 (5%)
Query: 14 DKEGNHQQTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLK---ATPCD 70
DK+G KHYH+ N+ + YL++ +C SIP+LI+YH+HNS G+ +RL+ +T +
Sbjct: 341 DKKGT---VKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKAN 397
Query: 71 RPAPPTAGLSHDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMSEDD 130
+ P + L + WE+ E+ L++ LG+GQF D AVKM+KEG+MSED+
Sbjct: 398 K-VPDSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDE 456
Query: 131 FIDEAKVM 138
F EA+ M
Sbjct: 457 FFQEAQTM 464
>UniRef50_Q60I21 Cluster: TEC family protein tyrosine kinase; n=1;
Eptatretus burgeri|Rep: TEC family protein tyrosine
kinase - Eptatretus burgeri (Inshore hagfish)
Length = 636
Score = 103 bits (247), Expect = 2e-21
Identities = 49/117 (41%), Positives = 70/117 (59%), Gaps = 1/117 (0%)
Query: 23 KHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLK-ATPCDRPAPPTAGLSH 81
KHYH+KQ GE+YL++KH ++I +LI+YH+HN+ GL +RL+ P TAGLS+
Sbjct: 309 KHYHVKQLPTGEWYLAEKHTFSTISDLIHYHQHNAAGLVTRLRHPVRPGEELPSTAGLSY 368
Query: 82 DKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMSEDDFIDEAKVM 138
KWE+D EL + LG G A++M+ EG ++EDDF E K+M
Sbjct: 369 GKWELDALELTSLRELGRGALGVVQLGMWRGVRHIAIRMLHEGVLAEDDFFHEVKLM 425
>UniRef50_UPI0000F1FB23 Cluster: PREDICTED: similar to tyrosine
protein kinase BTK; n=1; Danio rerio|Rep: PREDICTED:
similar to tyrosine protein kinase BTK - Danio rerio
Length = 596
Score = 90.6 bits (215), Expect = 1e-17
Identities = 50/116 (43%), Positives = 65/116 (56%), Gaps = 23/116 (19%)
Query: 23 KHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDRPAPPTAGLSHD 82
+HY+I + G+FYL++KH +IPELINYH+HN+ G
Sbjct: 292 RHYNILLTADGQFYLAEKHNFTNIPELINYHQHNAAG----------------------- 328
Query: 83 KWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMSEDDFIDEAKVM 138
WEIDP +L + LG GQF D A+KM+KEG+MSEDDFI+EAKVM
Sbjct: 329 SWEIDPRQLTFIRELGNGQFGVVKYGKWQGRHDVAIKMVKEGSMSEDDFIEEAKVM 384
>UniRef50_Q9NH62 Cluster: Tyrosine kinase 5; n=2; Schistosoma
mansoni|Rep: Tyrosine kinase 5 - Schistosoma mansoni
(Blood fluke)
Length = 647
Score = 89.8 bits (213), Expect = 2e-17
Identities = 48/124 (38%), Positives = 71/124 (57%), Gaps = 4/124 (3%)
Query: 23 KHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDRPAPPTAGLS-- 80
KHY IK +Y++ K +S+ ELI ++ +S GLC +L C P P T+ LS
Sbjct: 234 KHYRIKHPDYRYYYITTKCSFSSLQELIQFYSIDSHGLCCKLTRA-CLCPPPITSDLSVK 292
Query: 81 -HDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMSEDDFIDEAKVMT 139
D WEI S +VL+E LGAGQF + AVK +K+GTM+++DF+ EA++M
Sbjct: 293 TKDHWEISKSSIVLIEKLGAGQFGEVWKGTWNGTTEVAVKTLKQGTMTKEDFLKEARIMR 352
Query: 140 SVYY 143
+ +
Sbjct: 353 AAQH 356
>UniRef50_P51451 Cluster: Tyrosine-protein kinase BLK; n=5;
Euteleostomi|Rep: Tyrosine-protein kinase BLK - Homo
sapiens (Human)
Length = 505
Score = 83.4 bits (197), Expect = 2e-15
Identities = 44/121 (36%), Positives = 64/121 (52%), Gaps = 2/121 (1%)
Query: 23 KHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDRPAPPTAGLSHD 82
KHY I+ G +Y+S + S+ L+ ++ GLC RL PC RPAP + D
Sbjct: 175 KHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRL-TLPCVRPAPQNPW-AQD 232
Query: 83 KWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMSEDDFIDEAKVMTSVY 142
+WEI L L+ LG+GQF + A+K +KEGTMS + F+ EA VM ++
Sbjct: 233 EWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQ 292
Query: 143 Y 143
+
Sbjct: 293 H 293
>UniRef50_Q4RNX3 Cluster: Chromosome 10 SCAF15009, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 10 SCAF15009, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 466
Score = 81.4 bits (192), Expect = 9e-15
Identities = 46/134 (34%), Positives = 66/134 (49%), Gaps = 2/134 (1%)
Query: 10 LKREDKEGNHQQTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPC 69
L D + N KHY I+ G FY++ K S+ EL+ ++ +S GLC++L PC
Sbjct: 154 LSMRDFDNNGDGVKHYRIRNMDNGGFYITTKISFNSLKELVQHYSRDSDGLCTKL-VKPC 212
Query: 70 DRPAPPTAGLSHDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMSED 129
AP D+WEI L L LGAGQF A+K +K GTMS +
Sbjct: 213 QSKAPQKPWW-QDEWEIPRESLKLERKLGAGQFGEVWMGVYNNERRVAIKCLKIGTMSVE 271
Query: 130 DFIDEAKVMTSVYY 143
F+ EA +M ++ +
Sbjct: 272 AFLAEANMMKNLQH 285
>UniRef50_P00528 Cluster: Tyrosine-protein kinase Src64B; n=6;
Endopterygota|Rep: Tyrosine-protein kinase Src64B -
Drosophila melanogaster (Fruit fly)
Length = 552
Score = 81.0 bits (191), Expect = 1e-14
Identities = 47/134 (35%), Positives = 67/134 (50%), Gaps = 4/134 (2%)
Query: 8 SLLKREDKEGNHQQTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKAT 67
SL ++ ++G KHY IK G +Y++ S+ L+ + N+ GLC L +
Sbjct: 199 SLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKNALGLCHIL-SR 257
Query: 68 PCDRPAPPTAGLS---HDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEG 124
PC +P P L DK+EI SE+ L+ LG G F ID AVK ++EG
Sbjct: 258 PCPKPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREG 317
Query: 125 TMSEDDFIDEAKVM 138
TMS F+ EA +M
Sbjct: 318 TMSTAAFLQEAAIM 331
>UniRef50_P08631 Cluster: Tyrosine-protein kinase HCK; n=32;
Euteleostomi|Rep: Tyrosine-protein kinase HCK - Homo
sapiens (Human)
Length = 526
Score = 80.2 bits (189), Expect = 2e-14
Identities = 46/136 (33%), Positives = 68/136 (50%), Gaps = 2/136 (1%)
Query: 8 SLLKREDKEGNHQQTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKAT 67
SL R+ KHY I+ G FY+S + +++ EL++++K + GLC +L +
Sbjct: 181 SLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKL-SV 239
Query: 68 PCDRPAPPTAGLSHDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMS 127
PC + P D WEI L L + LGAGQF AVK MK G+MS
Sbjct: 240 PC-MSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMS 298
Query: 128 EDDFIDEAKVMTSVYY 143
+ F+ EA VM ++ +
Sbjct: 299 VEAFLAEANVMKTLQH 314
>UniRef50_Q70DV1 Cluster: Src tyrosine kinase; n=1; Schistosoma
mansoni|Rep: Src tyrosine kinase - Schistosoma mansoni
(Blood fluke)
Length = 647
Score = 78.6 bits (185), Expect = 6e-14
Identities = 49/147 (33%), Positives = 71/147 (48%), Gaps = 6/147 (4%)
Query: 2 SRQRAESLLKREDKEGNHQQTK-HYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGL 60
S+ SL RE+ H + + Y + FY+S + +I +L+N++ N GL
Sbjct: 253 SQSSEYSLSVREENTVKHYRIRSRYSRTDPTLKRFYISRQLPFVNIQQLVNHYLENQSGL 312
Query: 61 CSRLKATPCDRPA-PPTAGLSH---DKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDT 116
C RL PC RP P GLSH DKWEI S ++L E +G GQF
Sbjct: 313 CCRL-GKPCIRPTHPEPVGLSHKLIDKWEIPKSSIILKEKIGQGQFGEVFKAVWNKTTIV 371
Query: 117 AVKMMKEGTMSEDDFIDEAKVMTSVYY 143
AVK +K + DF+ EA+ M +++
Sbjct: 372 AVKTLKPSSCDAADFLREAQTMKRLHH 398
>UniRef50_Q8T6F8 Cluster: SRC-1; n=3; Caenorhabditis|Rep: SRC-1 -
Caenorhabditis elegans
Length = 533
Score = 76.6 bits (180), Expect = 2e-13
Identities = 44/133 (33%), Positives = 67/133 (50%), Gaps = 5/133 (3%)
Query: 10 LKREDKEGNHQQTKHYHIKQNSRGE-FYLSDKHCCASIPELINYHKHNSGGLCSRLKATP 68
++ D + N KHY IK+ + ++++ + S+ EL+ Y+ GLC +L P
Sbjct: 178 IRDTDDQRNGGTVKHYKIKRLDHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQL-TFP 236
Query: 69 CDRPAPPTAGLSHD---KWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGT 125
R AP LSHD WEI ++L L LG G F ++ A+K MK GT
Sbjct: 237 APRLAPTRPDLSHDTQQNWEIPRNQLHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGT 296
Query: 126 MSEDDFIDEAKVM 138
MS + F+ EA++M
Sbjct: 297 MSPEAFLQEAQIM 309
>UniRef50_P42686 Cluster: Tyrosine-protein kinase isoform SRK1;
n=11; Metazoa|Rep: Tyrosine-protein kinase isoform SRK1
- Spongilla lacustris (Freshwater sponge)
Length = 505
Score = 76.6 bits (180), Expect = 2e-13
Identities = 37/124 (29%), Positives = 68/124 (54%), Gaps = 3/124 (2%)
Query: 18 NHQQTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDRPAPPTA 77
+ + +HY +++ G +++ + + EL++++K + GLC +L P TA
Sbjct: 164 DQDRVRHYRVRRLEDGSLFVTRRSTFQILHELVDHYKIETDGLCCKLLYPCLQAEKPQTA 223
Query: 78 GL---SHDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMSEDDFIDE 134
GL ++++WEI+ +++ L+ LGAGQF AVK +K GTMS ++F+ E
Sbjct: 224 GLLRQANEEWEIEKTQIKLLRRLGAGQFGEVWEGLWNGTTSVAVKTLKPGTMSVEEFLQE 283
Query: 135 AKVM 138
A +M
Sbjct: 284 ASIM 287
>UniRef50_P42685 Cluster: Tyrosine-protein kinase FRK; n=27;
Fungi/Metazoa group|Rep: Tyrosine-protein kinase FRK -
Homo sapiens (Human)
Length = 505
Score = 76.2 bits (179), Expect = 3e-13
Identities = 41/123 (33%), Positives = 69/123 (56%), Gaps = 5/123 (4%)
Query: 23 KHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDR-PAPPTAGLSH 81
KHY IK+ G F+L+ + +++ E ++++ S GLC +L PC + P LS+
Sbjct: 163 KHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKL-GKPCLKIQVPAPFDLSY 221
Query: 82 ---DKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMSEDDFIDEAKVM 138
D+WEID + + L++ LG+GQF AVK +K G+M +DF+ EA++M
Sbjct: 222 KTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIM 281
Query: 139 TSV 141
++
Sbjct: 282 KNL 284
>UniRef50_Q66I04 Cluster: Zgc:92124; n=1; Danio rerio|Rep: Zgc:92124
- Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 510
Score = 74.9 bits (176), Expect = 7e-13
Identities = 42/136 (30%), Positives = 65/136 (47%), Gaps = 2/136 (1%)
Query: 8 SLLKREDKEGNHQQTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKAT 67
SL R+ KHY I+ G +Y+S K + I +I ++ S GLC +L
Sbjct: 164 SLSIRDVDAQGQDVVKHYKIRSLDNGGYYISPKITFSDISSMIKHYHKQSDGLCRKLDKA 223
Query: 68 PCDRPAPPTAGLSHDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMS 127
C++P D WEI + +++ LGAGQF AVK +K GTMS
Sbjct: 224 -CEKPKAQKPW-DKDAWEISKDSIKMVKKLGAGQFGEVWMAFYNNSTKVAVKTLKPGTMS 281
Query: 128 EDDFIDEAKVMTSVYY 143
+ F++EA +M ++ +
Sbjct: 282 VEAFLEEANLMKTLQH 297
>UniRef50_P07947 Cluster: Proto-oncogene tyrosine-protein kinase
Yes; n=422; root|Rep: Proto-oncogene tyrosine-protein
kinase Yes - Homo sapiens (Human)
Length = 543
Score = 74.9 bits (176), Expect = 7e-13
Identities = 44/134 (32%), Positives = 69/134 (51%), Gaps = 3/134 (2%)
Query: 6 AESLLKREDKEGNHQQTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLK 65
A SL R+ E KHY I++ G +Y++ + ++ +L+ ++ ++ GLC +L
Sbjct: 193 AYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKL- 251
Query: 66 ATPCDRPAPPTAGLSHDKWEIDPSELVLMEV-LGAGQFXXXXXXXXXXXIDTAVKMMKEG 124
T C P T GL+ D WEI P E + +EV LG G F A+K +K G
Sbjct: 252 TTVCPTVKPQTQGLAKDAWEI-PRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPG 310
Query: 125 TMSEDDFIDEAKVM 138
TM + F+ EA++M
Sbjct: 311 TMMPEAFLQEAQIM 324
>UniRef50_Q6R1Y3 Cluster: Src family kinase; n=6; Fungi/Metazoa
group|Rep: Src family kinase - Asterina miniata (Bat
star) (Patiria miniata)
Length = 563
Score = 72.9 bits (171), Expect = 3e-12
Identities = 42/131 (32%), Positives = 62/131 (47%), Gaps = 3/131 (2%)
Query: 8 SLLKREDKEGNHQQTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKAT 67
S+L +D G + KHY I+ +Y+S + ++ +L+N++ + GL RL
Sbjct: 222 SVLDHDDARGFN--VKHYRIRTLDNDGYYISTRITFHTLHDLVNHYTSQADGLVCRL-LN 278
Query: 68 PCDRPAPPTAGLSHDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMS 127
PC R P +S D WEI + L LG GQF + AVK +KEG M
Sbjct: 279 PCPRQKPVMFEISKDVWEIPRRSIKLERKLGNGQFGEVWEGTWNGTVRVAVKTLKEGAMD 338
Query: 128 EDDFIDEAKVM 138
F+ EA +M
Sbjct: 339 PTAFLQEANIM 349
>UniRef50_UPI0000E4736E Cluster: PREDICTED: similar to src-family
protein tyrosine kinase; n=2; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to src-family protein
tyrosine kinase - Strongylocentrotus purpuratus
Length = 387
Score = 69.7 bits (163), Expect = 3e-11
Identities = 46/141 (32%), Positives = 66/141 (46%), Gaps = 5/141 (3%)
Query: 8 SLLKREDKEGNHQQTKHYHI-KQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKA 66
S+ ++G+H KHY I K + F++ ++ EL+ +++ NS GLC +L
Sbjct: 44 SVRDNNPQKGDH--VKHYRIWKMDGGNSFFIFQGSVFPTVSELVRHYQMNSDGLCCKLTE 101
Query: 67 TPCDRPAPPTAGLSHDKWEIDPSELVLMEV-LGAGQFXXXXXXXXXXXIDTAVKMMKEGT 125
C + P T GL DKWE L M LG G+F AVK +KE T
Sbjct: 102 A-CPKENPNTIGLGKDKWETPRKSLGQMNRRLGEGKFGEVWQGVWNGNTPVAVKTLKERT 160
Query: 126 MSEDDFIDEAKVMTSVYYLSI 146
MS F+ EA VM + + I
Sbjct: 161 MSPAAFLAEANVMKKLRHEGI 181
>UniRef50_Q4RL31 Cluster: Chromosome undetermined SCAF15024, whole
genome shotgun sequence; n=8; Euteleostomi|Rep:
Chromosome undetermined SCAF15024, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 511
Score = 68.9 bits (161), Expect = 5e-11
Identities = 46/145 (31%), Positives = 67/145 (46%), Gaps = 11/145 (7%)
Query: 8 SLLKREDKEGNHQQTKHYHIKQNSRGEFYLSDKHCCASIPELI-NYHKHN--------SG 58
SL R+ +G KHY I+ G +Y+S K I +I +YH N +
Sbjct: 119 SLSVRDVDDGGTDLVKHYKIRLLDNGGYYISPKISFTDISSMIKHYHNRNPEPEPPGKAD 178
Query: 59 GLCSRLKATPCDRPAPPTAGLSHDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAV 118
GLC +L PC +P D WEI + +++ LGAGQF AV
Sbjct: 179 GLCRKLDR-PCVKPKAEKPW-DKDAWEISKDSIRMVKRLGAGQFGEVWMAYYNNITRVAV 236
Query: 119 KMMKEGTMSEDDFIDEAKVMTSVYY 143
K +K GTM+ + F+DEA +M + +
Sbjct: 237 KTLKPGTMTVEAFMDEANLMKKLQH 261
>UniRef50_P42684 Cluster: Tyrosine-protein kinase ABL2; n=38;
Euteleostomi|Rep: Tyrosine-protein kinase ABL2 - Homo
sapiens (Human)
Length = 1182
Score = 68.9 bits (161), Expect = 5e-11
Identities = 37/133 (27%), Positives = 70/133 (52%), Gaps = 4/133 (3%)
Query: 24 HYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLK--ATPCDRPAPPTAGLSH 81
HY I + G+ Y++ + +++ EL+++H + GL + L A C++P H
Sbjct: 219 HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIH 278
Query: 82 DKWEIDPSELVLMEVLGAGQFXXXXXXX-XXXXIDTAVKMMKEGTMSEDDFIDEAKVMTS 140
DKWE++ +++ + LG GQ+ + AVK +KE TM ++F+ EA VM
Sbjct: 279 DKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 338
Query: 141 VYYLSIHINKIGV 153
+ + ++ + +GV
Sbjct: 339 IKHPNL-VQLLGV 350
>UniRef50_UPI00015B4B0F Cluster: PREDICTED: similar to
proto-oncogene tyrosine-protein kinase abl1; n=1;
Nasonia vitripennis|Rep: PREDICTED: similar to
proto-oncogene tyrosine-protein kinase abl1 - Nasonia
vitripennis
Length = 1522
Score = 68.5 bits (160), Expect = 6e-11
Identities = 40/133 (30%), Positives = 72/133 (54%), Gaps = 4/133 (3%)
Query: 24 HYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDRPAPPTAGLS--H 81
HY I ++S G+ Y++ + ++ EL+++H + GL ++L R P LS
Sbjct: 221 HYRINEDSDGKMYVTTESIFNTLAELVHHHSMLADGLITQLLYPAPKRNKPTVFPLSPEP 280
Query: 82 DKWEIDPSELVLMEVLGAGQFXXXXXXX-XXXXIDTAVKMMKEGTMSEDDFIDEAKVMTS 140
D+WEI+ +++V+ LG GQ+ + AVK +KE TM+ DF++EA +M
Sbjct: 281 DEWEINRTDIVMRHKLGGGQYGDVYEAVWKRYNMTVAVKTLKEDTMALKDFLEEAAIMKE 340
Query: 141 VYYLSIHINKIGV 153
+ + ++ + IGV
Sbjct: 341 MKHRNL-VQLIGV 352
>UniRef50_P00519 Cluster: Proto-oncogene tyrosine-protein kinase
ABL1; n=35; root|Rep: Proto-oncogene tyrosine-protein
kinase ABL1 - Homo sapiens (Human)
Length = 1130
Score = 68.1 bits (159), Expect = 9e-11
Identities = 39/133 (29%), Positives = 69/133 (51%), Gaps = 4/133 (3%)
Query: 24 HYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDRPAPPTAGLS--H 81
HY I S G+ Y+S + ++ EL+++H + GL + L R P G+S +
Sbjct: 173 HYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNY 232
Query: 82 DKWEIDPSELVLMEVLGAGQFXXXXXXX-XXXXIDTAVKMMKEGTMSEDDFIDEAKVMTS 140
DKWE++ +++ + LG GQ+ + AVK +KE TM ++F+ EA VM
Sbjct: 233 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 292
Query: 141 VYYLSIHINKIGV 153
+ + ++ + +GV
Sbjct: 293 IKHPNL-VQLLGV 304
>UniRef50_P00521 Cluster: Tyrosine-protein kinase transforming
protein Abl; n=15; root|Rep: Tyrosine-protein kinase
transforming protein Abl - Abelson murine leukemia virus
Length = 746
Score = 67.7 bits (158), Expect = 1e-10
Identities = 39/133 (29%), Positives = 69/133 (51%), Gaps = 4/133 (3%)
Query: 24 HYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDRPAPPTAGLS--H 81
HY I S G+ Y+S + ++ EL+++H + GL + L R P G+S +
Sbjct: 59 HYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNY 118
Query: 82 DKWEIDPSELVLMEVLGAGQFXXXXXXX-XXXXIDTAVKMMKEGTMSEDDFIDEAKVMTS 140
DKWE++ +++ + LG GQ+ + AVK +KE TM ++F+ EA VM
Sbjct: 119 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 178
Query: 141 VYYLSIHINKIGV 153
+ + ++ + +GV
Sbjct: 179 IKHPNL-VQLLGV 190
>UniRef50_P10447 Cluster: Tyrosine-protein kinase transforming
protein Abl; n=57; root|Rep: Tyrosine-protein kinase
transforming protein Abl - Feline sarcoma virus (strain
Hardy-Zuckerman 2)
Length = 439
Score = 67.7 bits (158), Expect = 1e-10
Identities = 39/133 (29%), Positives = 69/133 (51%), Gaps = 4/133 (3%)
Query: 24 HYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDRPAPPTAGLS--H 81
HY I S G+ Y+S + ++ EL+++H + GL + L R P G+S +
Sbjct: 122 HYRINTASDGKLYVSPESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNY 181
Query: 82 DKWEIDPSELVLMEVLGAGQFXXXXXXX-XXXXIDTAVKMMKEGTMSEDDFIDEAKVMTS 140
DKWE++ +++ + LG GQ+ + AVK +KE TM ++F+ EA VM
Sbjct: 182 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 241
Query: 141 VYYLSIHINKIGV 153
+ + ++ + +GV
Sbjct: 242 IKHPNL-VQLLGV 253
>UniRef50_UPI0000519AF4 Cluster: PREDICTED: similar to Abl tyrosine
kinase CG4032-PA; n=1; Apis mellifera|Rep: PREDICTED:
similar to Abl tyrosine kinase CG4032-PA - Apis
mellifera
Length = 1439
Score = 64.1 bits (149), Expect = 1e-09
Identities = 36/133 (27%), Positives = 72/133 (54%), Gaps = 4/133 (3%)
Query: 24 HYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRL--KATPCDRPAPPTAGLSH 81
HY I ++S G+ +++ + ++ EL+++H + GL ++L A ++P
Sbjct: 220 HYRINEDSEGKMFVTTESKFNTLAELVHHHSMLADGLITQLLYPAPKHNKPTVFPLSPEP 279
Query: 82 DKWEIDPSELVLMEVLGAGQFXXXXXXX-XXXXIDTAVKMMKEGTMSEDDFIDEAKVMTS 140
D+WEI+ +++V+ LG GQ+ + AVK +KE TM+ DF++EA +M
Sbjct: 280 DEWEINRTDIVMRHKLGGGQYGDVYEAVWKRYNMTVAVKTLKEDTMALKDFLEEAAIMKE 339
Query: 141 VYYLSIHINKIGV 153
+ + ++ + +GV
Sbjct: 340 MKHRNL-VQLLGV 351
>UniRef50_UPI0000F1EB7D Cluster: PREDICTED: hypothetical protein;
n=3; Danio rerio|Rep: PREDICTED: hypothetical protein -
Danio rerio
Length = 510
Score = 59.7 bits (138), Expect = 3e-08
Identities = 36/122 (29%), Positives = 58/122 (47%), Gaps = 4/122 (3%)
Query: 20 QQTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDRPAPPTAGL 79
++ KH I QN FYL S+ +L++Y+ S S LK PC R P L
Sbjct: 170 REVKHIKIHQNQNESFYLDKSQTFQSLEKLVDYYWKYSLDGDSFLKQ-PCRRVKPKPKDL 228
Query: 80 SH---DKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMSEDDFIDEAK 136
SH + WE+ E L E LG G F ++ A+K++K +++ +F+ E +
Sbjct: 229 SHSTVNDWELPKEEFTLEEELGKGFFADVYRGKWKGMVNVAIKILKNDSINHREFMLETQ 288
Query: 137 VM 138
++
Sbjct: 289 IL 290
>UniRef50_P00522 Cluster: Tyrosine-protein kinase Abl; n=5;
Eumetazoa|Rep: Tyrosine-protein kinase Abl - Drosophila
melanogaster (Fruit fly)
Length = 1620
Score = 57.2 bits (132), Expect = 2e-07
Identities = 38/135 (28%), Positives = 70/135 (51%), Gaps = 6/135 (4%)
Query: 24 HYHIKQNSRGEFYLSDKHCCASIPELINYHK--HNSGGLCSRLKATPCDRPAPPTAGLSH 81
HY I ++ G+ +++ + ++ EL+++H H GL + L + P LS
Sbjct: 300 HYRISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSP 359
Query: 82 --DKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDT-AVKMMKEGTMSEDDFIDEAKVM 138
D+WEI +++++ LG GQ+ +T AVK +KE TM+ DF++EA +M
Sbjct: 360 EPDEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAIM 419
Query: 139 TSVYYLSIHINKIGV 153
+ + ++ + IGV
Sbjct: 420 KEMKHPNL-VQLIGV 433
>UniRef50_Q13882 Cluster: Tyrosine-protein kinase 6; n=11;
Mammalia|Rep: Tyrosine-protein kinase 6 - Homo sapiens
(Human)
Length = 451
Score = 55.2 bits (127), Expect = 6e-07
Identities = 40/145 (27%), Positives = 64/145 (44%), Gaps = 9/145 (6%)
Query: 20 QQTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDRPAPPTAGL 79
Q +HY I + + G +L++ S+PEL+NYH+ S RL A PC + P L
Sbjct: 122 QAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRL-AAPCRKHEPEP--L 178
Query: 80 SH-DKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMSEDDF----IDE 134
H D WE E L LG+G F + A+K++ + I
Sbjct: 179 PHWDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQA 238
Query: 135 AKVMTSVYYLSIH-INKIGVSVYIL 158
K + + L+++ + +G VYI+
Sbjct: 239 MKKLRHKHILALYAVVSVGDPVYII 263
>UniRef50_Q4TEC1 Cluster: Chromosome undetermined SCAF5507, whole
genome shotgun sequence; n=3; Tetraodontidae|Rep:
Chromosome undetermined SCAF5507, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 1116
Score = 53.2 bits (122), Expect = 3e-06
Identities = 34/129 (26%), Positives = 62/129 (48%), Gaps = 10/129 (7%)
Query: 24 HYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDRPAPPTAGL---- 79
H+ I+++S G +++SD+ A++ ELI+Y++ N+ L L PC + P T L
Sbjct: 298 HFRIQRSSIGAYFVSDRISFATLGELISYYQRNNRSL-GVLLEEPCAQQRPLTPSLLCLQ 356
Query: 80 ----SHDKWEIDPSELVLMEVLGAGQFXXX-XXXXXXXXIDTAVKMMKEGTMSEDDFIDE 134
+ WE E L+ LG G F A+K +K+ +D+F+ E
Sbjct: 357 RELFDMEPWERPREEFRLLRKLGEGHFGEVWEALWSTENRRVAIKTLKQEDTKQDEFVKE 416
Query: 135 AKVMTSVYY 143
+ + S+++
Sbjct: 417 VQALKSLHH 425
Score = 52.8 bits (121), Expect = 3e-06
Identities = 38/129 (29%), Positives = 62/129 (48%), Gaps = 13/129 (10%)
Query: 21 QTKHYHIKQNSRGEFYLSDKHCCASIPELINYHK----HNSGGLCSRLKATPCDRPA--P 74
Q KHY + Q + FY+ +S+ EL++Y++ +N+G L + K PA P
Sbjct: 759 QVKHYKVLQTDQNRFYVEPGRRFSSLAELVDYYQKTSLNNAGPLGNPCKRNTLSTPALLP 818
Query: 75 -PTAGLSHDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMK-EGTMSEDDFI 132
PT G WE+ E L E LG+G F I AVK++K + ++ DF
Sbjct: 819 FPTIG-----WELPKKEFELEEELGSGCFARVYRGRWKNLIRVAVKILKSDSELNHGDFQ 873
Query: 133 DEAKVMTSV 141
E +++ ++
Sbjct: 874 TEVQILKNL 882
Score = 50.4 bits (115), Expect = 2e-05
Identities = 36/115 (31%), Positives = 54/115 (46%), Gaps = 12/115 (10%)
Query: 21 QTKHYHIKQNSRGEFYLSDKHCCASIPELINYHK----HNSGGLCSRLKATPCDRPA--P 74
Q KHY + Q + FY+ +S+ EL++Y++ +N+G L + K PA P
Sbjct: 114 QVKHYKVLQTDQNRFYVEPGRRFSSLAELVDYYQKTSLNNAGPLGNPCKRNTLSTPALLP 173
Query: 75 -PTAGLSHDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMSE 128
PT G WE+ E L E LG+G F I AVK++K +S+
Sbjct: 174 FPTIG-----WELPKKEFELEEELGSGCFARVYRGRWKNLIRVAVKILKSAAVSK 223
>UniRef50_Q4RNL0 Cluster: Chromosome 21 SCAF15012, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 21
SCAF15012, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 509
Score = 51.6 bits (118), Expect = 8e-06
Identities = 30/75 (40%), Positives = 38/75 (50%), Gaps = 3/75 (4%)
Query: 67 TPCDRPAPPTAGLS---HDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKE 123
T C R P A LS D WEI L L++ LG GQF AVK +K
Sbjct: 167 TSCKRGMPKLADLSVKTKDMWEIPRESLQLIKKLGNGQFGEVWMGMWNGTTKVAVKTLKP 226
Query: 124 GTMSEDDFIDEAKVM 138
GTMS + F++EA++M
Sbjct: 227 GTMSPEAFLEEAQIM 241
>UniRef50_Q17MF5 Cluster: Tyrosine-protein kinase; n=2;
Culicidae|Rep: Tyrosine-protein kinase - Aedes aegypti
(Yellowfever mosquito)
Length = 747
Score = 50.0 bits (114), Expect = 2e-05
Identities = 33/124 (26%), Positives = 62/124 (50%), Gaps = 5/124 (4%)
Query: 19 HQQTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRL-KATPCDRPAPPTA 77
+++ +HY IK + + + D ++ +L+ ++ +S GLC++L KA P +
Sbjct: 419 NEKVEHYRIKY-AENKLTIDDDEYFDNLGQLVEHYTLDSDGLCTKLMKALPKEEFC--VK 475
Query: 78 GLSHDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMSEDDFIDEAKV 137
+ WEI +L L E +G G+F AVK++K+ + + F+ EA V
Sbjct: 476 DFQDNGWEIKMEDLQLKENIGKGEFGDVMLGILKGE-KVAVKVLKDAGRASNKFLAEAGV 534
Query: 138 MTSV 141
MT++
Sbjct: 535 MTTL 538
>UniRef50_P03949 Cluster: Tyrosine-protein kinase abl-1; n=5;
Caenorhabditis|Rep: Tyrosine-protein kinase abl-1 -
Caenorhabditis elegans
Length = 1224
Score = 50.0 bits (114), Expect = 2e-05
Identities = 35/138 (25%), Positives = 70/138 (50%), Gaps = 6/138 (4%)
Query: 24 HYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLK--ATPCD--RPAPPTAGL 79
HY I ++ + +++ + ++ EL+++H ++ GL L A+ D R +
Sbjct: 240 HYRINVDNTEKMFITQEVKFRTLGELVHHHSVHADGLICLLMYPASKKDKGRGLFSLSPN 299
Query: 80 SHDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDT-AVKMMKEGTMSEDDFIDEAKVM 138
+ D+WE+D SE+++ LG GQ+ T AVK +KE M +F+ EA +M
Sbjct: 300 APDEWELDRSEIIMHNKLGGGQYGDVYEGYWKRHDCTIAVKALKEDAMPLHEFLAEAAIM 359
Query: 139 TSVYYLSIHINKIGVSVY 156
+++ ++ + +GV +
Sbjct: 360 KDLHHKNL-VRLLGVCTH 376
>UniRef50_UPI00005A5E2E Cluster: PREDICTED: similar to Bruton
agammaglobulinemia tyrosine kinase isoform 2; n=1; Canis
lupus familiaris|Rep: PREDICTED: similar to Bruton
agammaglobulinemia tyrosine kinase isoform 2 - Canis
familiaris
Length = 109
Score = 49.2 bits (112), Expect = 4e-05
Identities = 23/42 (54%), Positives = 28/42 (66%)
Query: 97 LGAGQFXXXXXXXXXXXIDTAVKMMKEGTMSEDDFIDEAKVM 138
LG GQF D A+KM+KEG+MSED+FI+EAKVM
Sbjct: 61 LGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVM 102
>UniRef50_Q0PDJ5 Cluster: Protein tyrosine kinase CSK; n=1; Monosiga
ovata|Rep: Protein tyrosine kinase CSK - Monosiga ovata
Length = 468
Score = 48.4 bits (110), Expect = 7e-05
Identities = 37/137 (27%), Positives = 66/137 (48%), Gaps = 8/137 (5%)
Query: 21 QTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDRPAPPTAGLS 80
Q HY + Q G+ + ++ +S+ EL+ +++ ++ GLC+RL+ P + +
Sbjct: 144 QVDHYRM-QGKNGKLTIDEEVYFSSLEELVQHYEKDADGLCTRLR-KPVVKQGGREFKID 201
Query: 81 HDK---WEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMSE-DDFIDEAK 136
K WEI P E+V +G+GQF A+K +K+ D F+ EA
Sbjct: 202 ARKFVNWEISPREIVKSAQIGSGQFGDVFEGLYRGQ-KVAIKTLKDVQGDAIDQFLLEAD 260
Query: 137 VMTSVYYLSIHINKIGV 153
MT + + ++ + IGV
Sbjct: 261 TMTRLRHKNL-VQLIGV 276
>UniRef50_Q9H3Y6 Cluster: Tyrosine-protein kinase Srms; n=17;
Amniota|Rep: Tyrosine-protein kinase Srms - Homo sapiens
(Human)
Length = 488
Score = 46.8 bits (106), Expect = 2e-04
Identities = 30/115 (26%), Positives = 43/115 (37%), Gaps = 5/115 (4%)
Query: 24 HYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDRPAPPTAGLSHDK 83
HY + + G YL + EL+ Y+K N +L P +P P D
Sbjct: 168 HYRVSMAADGSLYLQKGRLFPGLEELLTYYKANW-----KLIQNPLLQPCMPQKAPRQDV 222
Query: 84 WEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMSEDDFIDEAKVM 138
WE SE L LG G F + A+K++K M D E + +
Sbjct: 223 WERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTL 277
>UniRef50_Q9Y1Z0 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 485
Score = 46.0 bits (104), Expect = 4e-04
Identities = 34/143 (23%), Positives = 68/143 (47%), Gaps = 11/143 (7%)
Query: 21 QTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDRPAP-----P 75
+ ++Y +++N +G + D ++ +L+ +++ + GLC+RLKA P D+
Sbjct: 152 RVENYRVRRNEKGLVTVDDDEYFDNLIKLVEHYQKEADGLCTRLKA-PVDKEGQHLFVVD 210
Query: 76 TAGLSHDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMSE---DDFI 132
W I + L+ ++G G+F A+K MK+ E F+
Sbjct: 211 VNDFKEKGWAIPKASLLKKSLIGKGEFGEVWLGDYEGK-KVAMKSMKDHLKDEKAKTQFL 269
Query: 133 DEAKVMTSVYYLSIHINKIGVSV 155
EA VMT++ + ++ + IG+S+
Sbjct: 270 AEASVMTTLRHPNL-VCLIGISL 291
>UniRef50_O77132 Cluster: Non-receptor protein-tyrosine kinase CSK;
n=1; Hydra vulgaris|Rep: Non-receptor protein-tyrosine
kinase CSK - Hydra attenuata (Hydra) (Hydra vulgaris)
Length = 467
Score = 43.6 bits (98), Expect = 0.002
Identities = 26/134 (19%), Positives = 63/134 (47%), Gaps = 6/134 (4%)
Query: 18 NHQQTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRL-----KATPCDRP 72
N+++ +HY + S + + ++ ++ ELI +++ ++ GLC+ L K T +
Sbjct: 135 NNKKVEHYRVISTSDNQVTVDEEAFFPTLIELIKHYEKDADGLCTMLKKPLKKKTEILQS 194
Query: 73 APPTAGLSHDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMSEDDFI 132
A + W + ++ E++G G+F A+K +++ + + +
Sbjct: 195 AIFKESFQKEGWAVPIEDVEFKELIGKGEFGNVYKGVWAKK-TVAIKKLRDDSKTAQSLL 253
Query: 133 DEAKVMTSVYYLSI 146
EA VMT++ + ++
Sbjct: 254 AEASVMTTLQHKNL 267
>UniRef50_A2RQD7 Cluster: Bcr-abl1 e19a2 chimeric protein; n=2; Homo
sapiens|Rep: Bcr-abl1 e19a2 chimeric protein - Homo
sapiens (Human)
Length = 498
Score = 42.3 bits (95), Expect = 0.005
Identities = 21/72 (29%), Positives = 39/72 (54%), Gaps = 2/72 (2%)
Query: 24 HYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDRPAPPTAGLS--H 81
HY I S G+ Y+S + ++ EL+++H + GL + L R P G+S +
Sbjct: 425 HYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPSVYGVSPNY 484
Query: 82 DKWEIDPSELVL 93
DKWE++ +++ +
Sbjct: 485 DKWEMERTDITM 496
>UniRef50_A2RQD6 Cluster: Bcr-abl1 e6a2 chimeric protein; n=10;
Euteleostomi|Rep: Bcr-abl1 e6a2 chimeric protein - Homo
sapiens (Human)
Length = 585
Score = 42.3 bits (95), Expect = 0.005
Identities = 21/72 (29%), Positives = 39/72 (54%), Gaps = 2/72 (2%)
Query: 24 HYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDRPAPPTAGLS--H 81
HY I S G+ Y+S + ++ EL+++H + GL + L R P G+S +
Sbjct: 512 HYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNY 571
Query: 82 DKWEIDPSELVL 93
DKWE++ +++ +
Sbjct: 572 DKWEMERTDITM 583
>UniRef50_A2RQD3 Cluster: Bcr-abl1 e13a3 chimeric protein; n=21;
Eumetazoa|Rep: Bcr-abl1 e13a3 chimeric protein - Homo
sapiens (Human)
Length = 235
Score = 42.3 bits (95), Expect = 0.005
Identities = 21/72 (29%), Positives = 39/72 (54%), Gaps = 2/72 (2%)
Query: 24 HYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDRPAPPTAGLS--H 81
HY I S G+ Y+S + ++ EL+++H + GL + L R P G+S +
Sbjct: 162 HYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNY 221
Query: 82 DKWEIDPSELVL 93
DKWE++ +++ +
Sbjct: 222 DKWEMERTDITM 233
>UniRef50_Q5BXT3 Cluster: SJCHGC03955 protein; n=1; Schistosoma
japonicum|Rep: SJCHGC03955 protein - Schistosoma
japonicum (Blood fluke)
Length = 190
Score = 41.9 bits (94), Expect = 0.006
Identities = 18/46 (39%), Positives = 29/46 (63%), Gaps = 1/46 (2%)
Query: 24 HYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGL-CSRLKATP 68
HY I Q+SRG FY+++ H ++ +LI +H ++ GL C L + P
Sbjct: 124 HYRISQDSRGLFYITEAHRFPTVVQLIEHHSRSADGLVCPLLYSVP 169
>UniRef50_Q613B1 Cluster: Putative uncharacterized protein CBG16480;
n=1; Caenorhabditis briggsae|Rep: Putative
uncharacterized protein CBG16480 - Caenorhabditis
briggsae
Length = 487
Score = 41.5 bits (93), Expect = 0.009
Identities = 30/121 (24%), Positives = 54/121 (44%), Gaps = 9/121 (7%)
Query: 2 SRQRAESLLKREDKEGNHQQTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLC 61
S +A L+ + + Q+ HY I+ N+ G+F ++ K S+ ELIN+HK N
Sbjct: 95 SSGQARHLILSVMQNESSQEAMHYVIR-NADGKFSITGKENFDSLIELINHHKQN----- 148
Query: 62 SRLKATPCDRPAPPTAGLSHDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMM 121
K + + + WE++ S++ + + LG G F I T ++M
Sbjct: 149 ---KLHEDNPKSVLINAIGRQPWELNHSDVTMTKTLGEGAFGEVKLGTLKMEITTEARLM 205
Query: 122 K 122
+
Sbjct: 206 R 206
>UniRef50_O77440 Cluster: Protein-tyrosine kinase HTK98; n=1; Hydra
vulgaris|Rep: Protein-tyrosine kinase HTK98 - Hydra
attenuata (Hydra) (Hydra vulgaris)
Length = 624
Score = 41.1 bits (92), Expect = 0.011
Identities = 24/63 (38%), Positives = 35/63 (55%), Gaps = 5/63 (7%)
Query: 24 HYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDRPAPPTA----GL 79
HY I++ G ++D EL+N+HK + GGL ++L PC+RPA A G+
Sbjct: 58 HYAIQRQPSGMVGIADGPQFPGPVELVNHHKTSLGGLMTKL-TYPCERPAGVKATAYKGI 116
Query: 80 SHD 82
SHD
Sbjct: 117 SHD 119
>UniRef50_Q70W05 Cluster: Src protein; n=1; Ciona intestinalis|Rep:
Src protein - Ciona intestinalis (Transparent sea
squirt)
Length = 355
Score = 40.3 bits (90), Expect = 0.020
Identities = 33/101 (32%), Positives = 47/101 (46%), Gaps = 10/101 (9%)
Query: 55 HNSGGLCSRLKATPCDRPAPPTAGLSHD---KWEIDPSELVLMEVLGAGQFXXXXXXXXX 111
+N G +R + T + A +GLSHD +WEID + L E LG G F
Sbjct: 110 NNHGDFLARRRTTNPNEYA--LSGLSHDLADEWEIDRKSIELKEKLGKGNFGEVYKGLWN 167
Query: 112 XXIDTAVKMM----KEGTMSEDDFIDEA-KVMTSVYYLSIH 147
AVK M K ++ED I+ A +V T + YL ++
Sbjct: 168 GTTRVAVKKMIKSEKGKDLNEDTLIEMAIQVATGMVYLEVN 208
>UniRef50_Q20933 Cluster: Putative uncharacterized protein; n=1;
Caenorhabditis elegans|Rep: Putative uncharacterized
protein - Caenorhabditis elegans
Length = 444
Score = 40.3 bits (90), Expect = 0.020
Identities = 29/125 (23%), Positives = 60/125 (48%), Gaps = 15/125 (12%)
Query: 20 QQTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDRPAPPTAGL 79
Q+ HY I+ S G + ++DK ++ EL+N+HK + + ++ P +
Sbjct: 53 QEVAHYVIR-TSDGAYSITDKIKFGTLTELVNHHK--QAKISEEVASSVLVNP------I 103
Query: 80 SHDKWEIDPSELVLMEVLGAGQF---XXXXXXXXXXXIDTAVKMMKEGTMSED---DFID 133
WE++ +++ + +VLG G F +D A+K+ K ++++ + I
Sbjct: 104 GRQSWELNHADITMTKVLGEGAFGEVKLGTLKMGSTTVDVAIKVAKLEKVTKEQIKEIIT 163
Query: 134 EAKVM 138
EA++M
Sbjct: 164 EARLM 168
>UniRef50_O01798 Cluster: Defective spermatogenesis protein 8; n=2;
Caenorhabditis|Rep: Defective spermatogenesis protein 8
- Caenorhabditis elegans
Length = 512
Score = 40.3 bits (90), Expect = 0.020
Identities = 33/134 (24%), Positives = 57/134 (42%), Gaps = 17/134 (12%)
Query: 21 QTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDRPAPPTAGLS 80
Q H +K+ + Y + K+ SI ELI YHK N P GL+
Sbjct: 156 QNIHVLVKRTKTKKLYWTKKYAFKSICELIAYHKRNH---------KPIYEGMTLICGLA 206
Query: 81 HDKWEIDPSELVLMEVLGAGQF-----XXXXXXXXXXXIDTAVKMMKEGTMSEDD---FI 132
W+++ ++ L + LG GQF + AVK + + +S ++ F+
Sbjct: 207 RHGWQLNNEQVTLNKKLGEGQFGEVHKGSLKTSVFAAPVTVAVKTLHQNHLSANEKILFL 266
Query: 133 DEAKVMTSVYYLSI 146
EA VM ++ + ++
Sbjct: 267 REANVMLTLSHPNV 280
>UniRef50_P41240 Cluster: Tyrosine-protein kinase CSK; n=21;
Deuterostomia|Rep: Tyrosine-protein kinase CSK - Homo
sapiens (Human)
Length = 450
Score = 40.3 bits (90), Expect = 0.020
Identities = 30/136 (22%), Positives = 64/136 (47%), Gaps = 5/136 (3%)
Query: 21 QTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRL-KATPCDRPAPPTAGL 79
+ +HY I ++ + + ++ ++ +L+ ++ ++ GLC+RL K +
Sbjct: 125 KVEHYRIMYHA-SKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEF 183
Query: 80 SHDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMSEDDFIDEAKVMT 139
W ++ EL L++ +G G+F AVK +K ++ F+ EA VMT
Sbjct: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATAQ-AFLAEASVMT 241
Query: 140 SVYYLSIHINKIGVSV 155
+ + ++ + +GV V
Sbjct: 242 QLRHSNL-VQLLGVIV 256
>UniRef50_Q7T0U4 Cluster: MGC68984 protein; n=2; Xenopus|Rep:
MGC68984 protein - Xenopus laevis (African clawed frog)
Length = 266
Score = 39.5 bits (88), Expect = 0.034
Identities = 18/68 (26%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 2 SRQRAESLLKREDKEGNHQQTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLC 61
+R + +L R+ + KHY I Q G FY++ + A++ ++++Y+ + G+C
Sbjct: 120 TRSGSYTLSIRKTNHTSRDSIKHYRIHQLDNGWFYIAPRLTFATLQDMVDYYSEVADGIC 179
Query: 62 SRLKATPC 69
L PC
Sbjct: 180 CTL-TEPC 186
>UniRef50_Q08BY6 Cluster: Zgc:153964; n=3; Danio rerio|Rep:
Zgc:153964 - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 511
Score = 39.1 bits (87), Expect = 0.045
Identities = 28/104 (26%), Positives = 46/104 (44%), Gaps = 3/104 (2%)
Query: 20 QQTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDRPAPPTAGL 79
+ KH+ I Q +FY+ +SI E+I +++ + + L + PC R P
Sbjct: 178 ENAKHFKIFQTG-DQFYVDALFKFSSIVEVIEHYQSHPLSI-GDLLSEPCIRIKPENVPP 235
Query: 80 -SHDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMK 122
S D+WE+ E L LG+G F A+K++K
Sbjct: 236 PSTDEWELPKEEFQLENQLGSGHFADVYSGKWKNHSKVAIKILK 279
>UniRef50_Q9BL77 Cluster: C-terminal src kinase protein 1; n=2;
Caenorhabditis|Rep: C-terminal src kinase protein 1 -
Caenorhabditis elegans
Length = 539
Score = 39.1 bits (87), Expect = 0.045
Identities = 16/50 (32%), Positives = 31/50 (62%), Gaps = 1/50 (2%)
Query: 19 HQQTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATP 68
H + +HY I+Q S G+ + +++ +L++++K ++ GLC RL TP
Sbjct: 192 HGKVEHYRIEQTSGGQLTCDKEEYFSNLTQLVSHYKRDADGLCHRL-VTP 240
>UniRef50_Q6NP28 Cluster: LP09923p; n=6; Endopterygota|Rep: LP09923p
- Drosophila melanogaster (Fruit fly)
Length = 847
Score = 38.3 bits (85), Expect = 0.079
Identities = 35/126 (27%), Positives = 61/126 (48%), Gaps = 9/126 (7%)
Query: 21 QTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRL-KATPCDRPAPPTAGL 79
+ +HY +K + + D+ ++ +L+ +++ ++ GLC++L K P
Sbjct: 522 KVEHYRVKY-LENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINS 580
Query: 80 SH--DK-WEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMK-EGTMSEDDFIDEA 135
DK W I +EL L E +G G+F AVKM+K EG + + F+ EA
Sbjct: 581 KDFVDKGWVIPEAELQLRESIGKGEFGDVMLGILRNE-KVAVKMLKDEGAVQK--FLAEA 637
Query: 136 KVMTSV 141
VMT++
Sbjct: 638 SVMTTL 643
>UniRef50_Q3ZB94 Cluster: Zgc:113360; n=3; Clupeocephala|Rep:
Zgc:113360 - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 271
Score = 37.9 bits (84), Expect = 0.11
Identities = 17/58 (29%), Positives = 32/58 (55%), Gaps = 1/58 (1%)
Query: 19 HQQTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDRPAPPT 76
H+ KHY I + + +Y+S + + +++N++ +S G+C L A PC + PT
Sbjct: 126 HRSVKHYKIFRLTNSWYYISPRLTFQCLEDMVNHYSDSSDGICCVLSA-PCLALSNPT 182
>UniRef50_Q13239 Cluster: SRC-like-adapter; n=26; Euteleostomi|Rep:
SRC-like-adapter - Homo sapiens (Human)
Length = 276
Score = 37.9 bits (84), Expect = 0.11
Identities = 17/51 (33%), Positives = 28/51 (54%), Gaps = 1/51 (1%)
Query: 19 HQQTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPC 69
H+Q KHY I + +Y+S + + +L+N++ + GLC L TPC
Sbjct: 126 HRQVKHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEVADGLCCVL-TTPC 175
>UniRef50_Q7T6Y2 Cluster: Putative serine/threonine-protein
kinase/receptor R831 precursor; n=1; Acanthamoeba
polyphaga mimivirus|Rep: Putative
serine/threonine-protein kinase/receptor R831 precursor
- Mimivirus
Length = 1624
Score = 37.5 bits (83), Expect = 0.14
Identities = 22/70 (31%), Positives = 38/70 (54%), Gaps = 4/70 (5%)
Query: 80 SHDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMSED---DFIDEAK 136
+++ WEID SEL + E LG G + + AVK++ +S+D F +E K
Sbjct: 775 TNNDWEIDFSELEIGETLGTGGYGEVYKSIWKGT-EVAVKLISSKHVSKDMERSFFEEVK 833
Query: 137 VMTSVYYLSI 146
+MTS+ + ++
Sbjct: 834 IMTSLRHPNV 843
>UniRef50_Q07407 Cluster: Fibroblast growth factor receptor homolog
1 precursor; n=3; Sophophora|Rep: Fibroblast growth
factor receptor homolog 1 precursor - Drosophila
melanogaster (Fruit fly)
Length = 729
Score = 37.5 bits (83), Expect = 0.14
Identities = 25/70 (35%), Positives = 33/70 (47%), Gaps = 2/70 (2%)
Query: 84 WEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMSEDDFIDEAKVMTSVYY 143
WE+ S LVL LG G F I AVKM+KEG ++DD + M +
Sbjct: 409 WELPRSHLVLGATLGEGAFGRVVMAEVNNAI-VAVKMVKEG-HTDDDIASLVREMEVMKI 466
Query: 144 LSIHINKIGV 153
+ HIN I +
Sbjct: 467 IGRHINIINL 476
>UniRef50_UPI0000E49A5C Cluster: PREDICTED: similar to TEK tyrosine
kinase, endothelial (venous malformations, multiple
cutaneous and mucosal); n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to TEK tyrosine
kinase, endothelial (venous malformations, multiple
cutaneous and mucosal) - Strongylocentrotus purpuratus
Length = 1137
Score = 36.7 bits (81), Expect = 0.24
Identities = 33/108 (30%), Positives = 44/108 (40%), Gaps = 11/108 (10%)
Query: 51 NYHKHNSGGLCSRLKATPCDRPAPPTAGLSHDKWEIDPSELVLMEVLGA----GQFXXXX 106
N + NS GL A+P P PP D W I L L + A GQ
Sbjct: 898 NDYDENSRGLMLGAMASPPGSPLPPI-----DYWRIPLDCLTLENFVIAEGNFGQVMKAT 952
Query: 107 XXXXXXXIDTAVKMMKEGTMSED--DFIDEAKVMTSVYYLSIHINKIG 152
I+ AVK +K+GT D DF+ E ++M V +N +G
Sbjct: 953 VKKDGGVIEVAVKTLKDGTSEADRKDFMGELEIMCKVGTHPNIVNLVG 1000
>UniRef50_Q7T6X2 Cluster: Putative serine/threonine-protein
kinase/receptor R826 precursor; n=2; Acanthamoeba
polyphaga mimivirus|Rep: Putative
serine/threonine-protein kinase/receptor R826 precursor
- Mimivirus
Length = 1657
Score = 36.7 bits (81), Expect = 0.24
Identities = 27/73 (36%), Positives = 41/73 (56%), Gaps = 6/73 (8%)
Query: 78 GLSHDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMK-EGTMSED---DFID 133
G+S D WEID EL L E LG G F + AVKM+ + T+++D +F D
Sbjct: 774 GISDD-WEIDFHELELGEQLGTGAFGEVHKGTWRGT-EVAVKMISPDKTITKDIERNFKD 831
Query: 134 EAKVMTSVYYLSI 146
E +VMT++ + ++
Sbjct: 832 EVRVMTTLRHPNV 844
>UniRef50_UPI0000F2B3BE Cluster: PREDICTED: similar to
Src-like-adaptor 2; n=1; Monodelphis domestica|Rep:
PREDICTED: similar to Src-like-adaptor 2 - Monodelphis
domestica
Length = 310
Score = 36.3 bits (80), Expect = 0.32
Identities = 29/110 (26%), Positives = 46/110 (41%), Gaps = 12/110 (10%)
Query: 2 SRQRAESLLKREDKEGNHQQTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLC 61
+R+ A SL R + + +HY I + G FY+S + S+ L+ ++ + LC
Sbjct: 165 TRRGAYSLSVRLSRPTSRDVVRHYRIHRLENGWFYISPRLTFPSLQALVEHYTEMADDLC 224
Query: 62 SRLKATPC---------DRPAPPTAGLSHD--KWEIDPSELVLMEVLGAG 100
S L PC R PP + W+ S L+ EV +G
Sbjct: 225 S-LLVEPCAFRRVGLLPGRNIPPPVSVQRPTLNWKEVDSSLLFSEVSSSG 273
>UniRef50_Q9Y1X9 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 573
Score = 36.3 bits (80), Expect = 0.32
Identities = 23/74 (31%), Positives = 33/74 (44%), Gaps = 3/74 (4%)
Query: 24 HYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDRPAPPTAG---LS 80
HY I ++ G + D S ELI YH GL + LK C P P G +S
Sbjct: 57 HYIISRHPDGSVAIQDGAKFDSPIELIQYHTKKVDGLITTLKQPCCRLPGQPPQGYRFIS 116
Query: 81 HDKWEIDPSELVLM 94
H++ ++ E L+
Sbjct: 117 HEEMQMAMREAALL 130
>UniRef50_UPI0000D5603D Cluster: PREDICTED: similar to Insulin
receptor precursor (IR); n=1; Tribolium castaneum|Rep:
PREDICTED: similar to Insulin receptor precursor (IR) -
Tribolium castaneum
Length = 1293
Score = 35.9 bits (79), Expect = 0.42
Identities = 26/78 (33%), Positives = 39/78 (50%), Gaps = 7/78 (8%)
Query: 82 DKWEIDPSELVLMEVLGAGQFXXXXXXXX----XXXIDTAVKMMKEGTMSED--DFIDEA 135
DKWEI + +V+ LG G F + AVK +K G+ +E+ DF+ EA
Sbjct: 892 DKWEIPRNSVVINRKLGEGAFGTVYGGEANFPDKGWVAVAVKTLKVGSSTEEKLDFLSEA 951
Query: 136 KVMTSVYYLSIHINKIGV 153
+VM + +I I +GV
Sbjct: 952 EVMKRFDHKNI-IKLLGV 968
>UniRef50_Q5DM52 Cluster: Receptor tyrosine kinase Torso-like
protein; n=1; Tribolium castaneum|Rep: Receptor tyrosine
kinase Torso-like protein - Tribolium castaneum (Red
flour beetle)
Length = 803
Score = 35.9 bits (79), Expect = 0.42
Identities = 25/77 (32%), Positives = 34/77 (44%), Gaps = 6/77 (7%)
Query: 82 DKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXID----TAVKMMKEGTMSED--DFIDEA 135
D+WE+ P +L V+G G F D AVKM+KE SE+ F E
Sbjct: 442 DQWELGPLKLSFQGVIGEGAFGIVRRAFLDLKEDNKTQVAVKMLKESPTSEEIRQFTQEI 501
Query: 136 KVMTSVYYLSIHINKIG 152
+M SV ++ IG
Sbjct: 502 NIMKSVRQHPYIVSLIG 518
>UniRef50_P42687 Cluster: Tyrosine-protein kinase SPK-1; n=1;
Girardia tigrina|Rep: Tyrosine-protein kinase SPK-1 -
Dugesia tigrina (Planarian)
Length = 497
Score = 35.9 bits (79), Expect = 0.42
Identities = 32/134 (23%), Positives = 56/134 (41%), Gaps = 7/134 (5%)
Query: 23 KHYHIK--QNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPC-DRPAPPTAGL 79
KH+ IK Q+ +G Y + +I LI +++ N G P D PP +
Sbjct: 152 KHFQIKTLQDEKGISYSVNIRNFPNILTLIQFYEKNGIGNTHIPLTDPMPDNYQPP---V 208
Query: 80 SHDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMSEDDFIDEAKVMT 139
EI+ + ++ +G G F + A KM++ + F+ EAK+M
Sbjct: 209 HFQDIEINRENIEILNEIGRGFFGSVHRAKWGRSYEVAAKMLQSSKAEREKFVLEAKIMH 268
Query: 140 SVYYLSIHINKIGV 153
+ + I + +GV
Sbjct: 269 KLRHRKI-VELLGV 281
>UniRef50_P16591 Cluster: Proto-oncogene tyrosine-protein kinase
FER; n=109; root|Rep: Proto-oncogene tyrosine-protein
kinase FER - Homo sapiens (Human)
Length = 822
Score = 35.9 bits (79), Expect = 0.42
Identities = 29/112 (25%), Positives = 50/112 (44%), Gaps = 9/112 (8%)
Query: 44 ASIPELINYHKHNSGGLCSRLKATPCDRPAPPTAGLSHDKWEIDPSELVLMEVLGAGQFX 103
++IP+LI++H + + + ++ P P KW + +++L E+LG G F
Sbjct: 522 SNIPQLIDHH-YTTKQVITKKSGVVLLNPIP-----KDKKWILSHEDVILGELLGKGNFG 575
Query: 104 XXXXXXXXXXIDTAVKMMKEGTMSE--DDFIDEAKVMTSVYYLSIHINKIGV 153
AVK KE E F+ EAK++ + +I + IGV
Sbjct: 576 EVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNI-VKLIGV 626
>UniRef50_Q4SR72 Cluster: Chromosome 11 SCAF14528, whole genome
shotgun sequence; n=3; Clupeocephala|Rep: Chromosome 11
SCAF14528, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 236
Score = 35.5 bits (78), Expect = 0.56
Identities = 18/47 (38%), Positives = 25/47 (53%), Gaps = 1/47 (2%)
Query: 23 KHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPC 69
KHY I G Y+S S+ L+ ++ ++GGLC RL A PC
Sbjct: 130 KHYRICCLQNGWVYISPGLTFPSLHHLVEHYSESAGGLCCRLTA-PC 175
>UniRef50_UPI0000E47549 Cluster: PREDICTED: similar to Cek8; n=2;
Strongylocentrotus purpuratus|Rep: PREDICTED: similar to
Cek8 - Strongylocentrotus purpuratus
Length = 775
Score = 35.1 bits (77), Expect = 0.74
Identities = 21/70 (30%), Positives = 33/70 (47%), Gaps = 6/70 (8%)
Query: 75 PTAGLSHDKWEIDPSELVLMEVLGAGQF----XXXXXXXXXXXIDTAVKMMKEGTMSED- 129
P + EID +++ ++EV+G G+F I AVK +K G +D
Sbjct: 401 PNQAVKEFATEIDATQIRILEVIGGGEFGDVCSGLMLMPDKTTIKVAVKTLKTGATDKDR 460
Query: 130 -DFIDEAKVM 138
DF+ EA +M
Sbjct: 461 SDFLSEASIM 470
>UniRef50_Q1HTP2 Cluster: Tyrosine-protein kinase receptor; n=4;
Percomorpha|Rep: Tyrosine-protein kinase receptor -
Haplochromis burtoni (Burton's mouthbrooder)
Length = 1024
Score = 35.1 bits (77), Expect = 0.74
Identities = 23/75 (30%), Positives = 37/75 (49%), Gaps = 8/75 (10%)
Query: 84 WEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDT-----AVKMMKEGTMSEDDFIDEAKVM 138
WEID +VL +VLG+G F I++ AVKM+K + + + E KV+
Sbjct: 572 WEIDRDHVVLGQVLGSGAFGRVVEATISGLINSHSTKAAVKMVKPRSDAVQSLMSELKVL 631
Query: 139 TSVYYLSIHINKIGV 153
+L H+N + +
Sbjct: 632 V---HLGPHLNVVNL 643
>UniRef50_P53356 Cluster: Tyrosine-protein kinase HTK16; n=1; Hydra
vulgaris|Rep: Tyrosine-protein kinase HTK16 - Hydra
attenuata (Hydra) (Hydra vulgaris)
Length = 757
Score = 35.1 bits (77), Expect = 0.74
Identities = 21/75 (28%), Positives = 37/75 (49%), Gaps = 5/75 (6%)
Query: 20 QQTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLK-----ATPCDRPAP 74
++T H+ IK + FY+ D ++P L++++ + GL + L+ A RP P
Sbjct: 331 KKTYHFQIKSRADRWFYIDDGPLFETLPHLVDHYMQYADGLPTLLQFPVPSAENRKRPLP 390
Query: 75 PTAGLSHDKWEIDPS 89
PT + K + PS
Sbjct: 391 PTPTKNQLKLPVPPS 405
>UniRef50_UPI0000DB7735 Cluster: PREDICTED: similar to Insulin
receptor precursor (IR); n=1; Apis mellifera|Rep:
PREDICTED: similar to Insulin receptor precursor (IR) -
Apis mellifera
Length = 1374
Score = 34.3 bits (75), Expect = 1.3
Identities = 25/80 (31%), Positives = 38/80 (47%), Gaps = 7/80 (8%)
Query: 82 DKWEIDPSELVLMEVLGAGQFXXXXXXXX----XXXIDTAVKMMKEGTMSED--DFIDEA 135
DKWEI +V+ LG G F + AVK +K G+ +E+ DF+ E
Sbjct: 933 DKWEIPRHRVVINRKLGEGAFGTVYGGEAFFPEKGWLAVAVKTLKIGSSTEEKLDFLSEV 992
Query: 136 KVMTSVYYLSIHINKIGVSV 155
+VM + +I I +GV +
Sbjct: 993 EVMKQFEHKNI-IKLLGVCI 1011
>UniRef50_Q9XXE5 Cluster: Putative uncharacterized protein; n=1;
Caenorhabditis elegans|Rep: Putative uncharacterized
protein - Caenorhabditis elegans
Length = 245
Score = 34.3 bits (75), Expect = 1.3
Identities = 30/130 (23%), Positives = 55/130 (42%), Gaps = 19/130 (14%)
Query: 20 QQTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDRPAPPTAGL 79
++ KHY IK ++G+ +K SIPE++ +H K + +
Sbjct: 66 EEIKHYVIK--TKGDKIFIEKVSFLSIPEMVEWHL---------TKKESVQKDVFLIKAI 114
Query: 80 SHDKWEIDPSELVLMEVLGAGQF-----XXXXXXXXXXXIDTAVKMMKEGTMSED---DF 131
S WE+D + ++ LG G F + A+K K ++++ +F
Sbjct: 115 SRQAWELDHDNIEPLKKLGEGAFGEVMMGTMKFRKGGKSVQVAIKQAKLSNLTKEQIKEF 174
Query: 132 IDEAKVMTSV 141
+ EA+VM S+
Sbjct: 175 MGEARVMRSL 184
>UniRef50_Q16YD9 Cluster: Kinase suppressor of ras; n=1; Aedes
aegypti|Rep: Kinase suppressor of ras - Aedes aegypti
(Yellowfever mosquito)
Length = 742
Score = 34.3 bits (75), Expect = 1.3
Identities = 19/78 (24%), Positives = 39/78 (50%), Gaps = 2/78 (2%)
Query: 74 PPTAGLSHDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMSEDDFID 133
P +S +W+I +L L+E +G G+F D AVK++KE ++++ ++
Sbjct: 462 PRQNSISLKEWDIPYDDLKLLEKIGNGRFGTVHRALWHG--DVAVKLLKEDYVADERTLE 519
Query: 134 EAKVMTSVYYLSIHINKI 151
K+ + + + H N +
Sbjct: 520 AFKLEVATFKKTRHENVV 537
>UniRef50_P18106 Cluster: Tyrosine-protein kinase Fps85D; n=12;
Eumetazoa|Rep: Tyrosine-protein kinase Fps85D -
Drosophila melanogaster (Fruit fly)
Length = 1325
Score = 34.3 bits (75), Expect = 1.3
Identities = 33/136 (24%), Positives = 58/136 (42%), Gaps = 12/136 (8%)
Query: 23 KHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDRPAPPTAGLSHD 82
KH+ ++ G F ASI ELI + H+ + + A RP + +
Sbjct: 1003 KHFIVQTTGEGNFRFEGPPF-ASIQELIMHQYHSELPVTVKSGAI-LRRP------VCRE 1054
Query: 83 KWEIDPSELVLMEVLGAGQF-XXXXXXXXXXXIDTAVKMMKEGTMSED--DFIDEAKVMT 139
+WE+ ++VL+E +G G F +D AVK + E F+ E +++
Sbjct: 1055 RWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILK 1114
Query: 140 SVYYLSIHINKIGVSV 155
+ +I + IG+ V
Sbjct: 1115 QYDHPNI-VKLIGICV 1129
>UniRef50_UPI0000F1F44E Cluster: PREDICTED: similar to
Src-like-adaptor 2; n=1; Danio rerio|Rep: PREDICTED:
similar to Src-like-adaptor 2 - Danio rerio
Length = 193
Score = 33.9 bits (74), Expect = 1.7
Identities = 24/94 (25%), Positives = 40/94 (42%), Gaps = 9/94 (9%)
Query: 17 GNHQQTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNS-GGLC-----SRLK---AT 67
G HY I Q G FY+ H +++ +L++Y+ +S G C RL T
Sbjct: 74 GQMHTVLHYKIYQLHNGWFYIQPNHPFSTLSQLVDYYSRSSVGSFCHLTEPCRLHDSIPT 133
Query: 68 PCDRPAPPTAGLSHDKWEIDPSELVLMEVLGAGQ 101
P+P A S+ W + ++ ++ G Q
Sbjct: 134 AAHSPSPVAAQKSNFNWRELSTSMIKRQLKGMDQ 167
>UniRef50_UPI0000D55B96 Cluster: PREDICTED: similar to
Tyrosine-protein kinase Src64B (Dsrc64) isoform 2; n=1;
Tribolium castaneum|Rep: PREDICTED: similar to
Tyrosine-protein kinase Src64B (Dsrc64) isoform 2 -
Tribolium castaneum
Length = 473
Score = 33.9 bits (74), Expect = 1.7
Identities = 14/25 (56%), Positives = 19/25 (76%)
Query: 114 IDTAVKMMKEGTMSEDDFIDEAKVM 138
I+ AVKM++EGTMS F+ EA +M
Sbjct: 228 IEVAVKMLREGTMSTQAFLQEAAIM 252
>UniRef50_Q7PXM5 Cluster: ENSANGP00000009647; n=2; Eumetazoa|Rep:
ENSANGP00000009647 - Anopheles gambiae str. PEST
Length = 944
Score = 33.5 bits (73), Expect = 2.3
Identities = 20/78 (25%), Positives = 38/78 (48%), Gaps = 2/78 (2%)
Query: 74 PPTAGLSHDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMSEDDFID 133
P LS +W+I +L L E +G G+F D AVK++KE ++++ ++
Sbjct: 640 PRQNSLSLKEWDIPYDDLHLKEKIGNGRFGTVHRALWHG--DVAVKLLKEDYVADERTLE 697
Query: 134 EAKVMTSVYYLSIHINKI 151
K+ + + + H N +
Sbjct: 698 AFKLEVATFKKTRHENVV 715
>UniRef50_Q17JW1 Cluster: Tyrosine protein kinase; n=2;
Culicidae|Rep: Tyrosine protein kinase - Aedes aegypti
(Yellowfever mosquito)
Length = 722
Score = 33.5 bits (73), Expect = 2.3
Identities = 21/63 (33%), Positives = 30/63 (47%), Gaps = 6/63 (9%)
Query: 82 DKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXID----TAVKMMKEGTMSED--DFIDEA 135
DKWE+ +V+ LG G F + AVK +K G+ +ED DF+ EA
Sbjct: 284 DKWEVPKDRVVINRRLGEGAFGTVYGGEAQIGDEGWTAVAVKTLKIGSTTEDKVDFLSEA 343
Query: 136 KVM 138
+ M
Sbjct: 344 EAM 346
>UniRef50_UPI00015B47C1 Cluster: PREDICTED: similar to gag-pol
polyprotein; n=2; Nasonia vitripennis|Rep: PREDICTED:
similar to gag-pol polyprotein - Nasonia vitripennis
Length = 1161
Score = 33.1 bits (72), Expect = 3.0
Identities = 18/49 (36%), Positives = 25/49 (51%), Gaps = 4/49 (8%)
Query: 33 GEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDRPAPPTAGLSH 81
G+F++SD H A+ P + + GL RL+A P R PP L H
Sbjct: 909 GDFFVSDSHPGANAPAFVAELR----GLIGRLRAAPGSRHLPPRTPLFH 953
>UniRef50_UPI0000E47068 Cluster: PREDICTED: similar to tyrosine
protein kinase; n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to tyrosine protein kinase -
Strongylocentrotus purpuratus
Length = 1566
Score = 33.1 bits (72), Expect = 3.0
Identities = 25/78 (32%), Positives = 37/78 (47%), Gaps = 7/78 (8%)
Query: 82 DKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXID----TAVKMMKEGTMSED--DFIDEA 135
D+WE+ +VL LG G F + AVK +K G E+ DF+ EA
Sbjct: 1011 DEWEMPRENVVLNRKLGEGAFGTVYGGEALLDDNKWAAVAVKTLKLGASVEEKLDFLSEA 1070
Query: 136 KVMTSVYYLSIHINKIGV 153
+VM + +I +N +GV
Sbjct: 1071 EVMKRFNHKNI-VNLLGV 1087
>UniRef50_Q45FX5 Cluster: Protein vav-1; n=4; Caenorhabditis|Rep:
Protein vav-1 - Caenorhabditis elegans
Length = 1007
Score = 33.1 bits (72), Expect = 3.0
Identities = 14/35 (40%), Positives = 22/35 (62%)
Query: 23 KHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNS 57
KH I+QNS G+ YL + + S EL+ Y++ N+
Sbjct: 875 KHMIIEQNSDGKVYLDEDYIFNSTVELVQYYRSNN 909
>UniRef50_Q9UF33 Cluster: Ephrin type-A receptor 6 precursor; n=57;
Euteleostomi|Rep: Ephrin type-A receptor 6 precursor -
Homo sapiens (Human)
Length = 1035
Score = 33.1 bits (72), Expect = 3.0
Identities = 21/60 (35%), Positives = 29/60 (48%), Gaps = 6/60 (10%)
Query: 85 EIDPSELVLMEVLGAGQF----XXXXXXXXXXXIDTAVKMMKEGTMSED--DFIDEAKVM 138
EIDPS + + V+GAG+F I A+K +K G M DF+ EA +M
Sbjct: 624 EIDPSRIRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIM 683
>UniRef50_UPI0000D577C3 Cluster: PREDICTED: similar to CG8874-PB,
isoform B; n=3; Endopterygota|Rep: PREDICTED: similar to
CG8874-PB, isoform B - Tribolium castaneum
Length = 801
Score = 32.7 bits (71), Expect = 3.9
Identities = 30/136 (22%), Positives = 58/136 (42%), Gaps = 12/136 (8%)
Query: 23 KHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDRPAPPTAGLSHD 82
KH+ ++ + G Y + SI +LI Y ++ SG + +P P +
Sbjct: 479 KHFIVQTTAEGH-YRFEGPAFPSIRDLILY-QYTSGLPVTGRSGALLYKPIP------RE 530
Query: 83 KWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMSED---DFIDEAKVMT 139
+WE++ ++VL++ +G G F D T+ ED F+ E +++
Sbjct: 531 RWELNNDDVVLLDKIGRGNFGDVYRAQLKNSNDVVAVKTCRVTLPEDHKKKFLQEGRILK 590
Query: 140 SVYYLSIHINKIGVSV 155
+ +I + IG+ V
Sbjct: 591 QYDHPNI-VKLIGICV 605
>UniRef50_A5AKP8 Cluster: Putative uncharacterized protein; n=1;
Vitis vinifera|Rep: Putative uncharacterized protein -
Vitis vinifera (Grape)
Length = 320
Score = 32.7 bits (71), Expect = 3.9
Identities = 16/45 (35%), Positives = 24/45 (53%), Gaps = 1/45 (2%)
Query: 80 SHDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEG 124
+ ++WEIDPS+LV+ V+ G F D AVK++ G
Sbjct: 46 TREEWEIDPSKLVIKSVIARGTFGTVHRGVYDGQ-DVAVKLLDWG 89
>UniRef50_A1RYL7 Cluster: Sec-independent translocation protein
mttA/Hcf106; n=1; Thermofilum pendens Hrk 5|Rep:
Sec-independent translocation protein mttA/Hcf106 -
Thermofilum pendens (strain Hrk 5)
Length = 111
Score = 32.7 bits (71), Expect = 3.9
Identities = 19/68 (27%), Positives = 33/68 (48%), Gaps = 3/68 (4%)
Query: 73 APPTAGLSHDKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGTMSEDDFI 132
APPT L +++I P+EL+L+ +L F AV++ +E T +
Sbjct: 6 APPTVSL---QFQIGPTELILLIILALILFGPKKLPELAKAAGEAVRVFREETQKVTSSV 62
Query: 133 DEAKVMTS 140
+E++ TS
Sbjct: 63 EESRTTTS 70
>UniRef50_Q6J4P8 Cluster: Insulin-like receptor; n=2; Apis
mellifera|Rep: Insulin-like receptor - Apis mellifera
ligustica (Common honeybee)
Length = 238
Score = 32.3 bits (70), Expect = 5.2
Identities = 21/75 (28%), Positives = 36/75 (48%), Gaps = 5/75 (6%)
Query: 82 DKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKE--GTMSEDDFIDEAKVMT 139
D+WE+ + + LG G F I A+K + + +++F++EA VM
Sbjct: 83 DEWEVPRESVEISNELGLGNFGMVYKGVYDKTIPVAIKTISKTASQREKNEFLNEASVMK 142
Query: 140 SVYYLSIHINK-IGV 153
+ + + HI K IGV
Sbjct: 143 N--FSTFHIIKLIGV 155
>UniRef50_UPI000069DB6A Cluster: Ephrin type-A receptor 6 precursor
(EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2)
(EPH homology kinase 2).; n=2; Xenopus tropicalis|Rep:
Ephrin type-A receptor 6 precursor (EC 2.7.10.1)
(Tyrosine-protein kinase receptor EHK-2) (EPH homology
kinase 2). - Xenopus tropicalis
Length = 952
Score = 31.9 bits (69), Expect = 6.9
Identities = 20/60 (33%), Positives = 29/60 (48%), Gaps = 6/60 (10%)
Query: 85 EIDPSELVLMEVLGAGQF----XXXXXXXXXXXIDTAVKMMKEGTMSED--DFIDEAKVM 138
EIDPS + + V+GAG+F I A+K +K G + DF+ EA +M
Sbjct: 582 EIDPSRIRIERVIGAGEFGEVCSGRLKTPAKKEIPVAIKTLKGGYVDRQRKDFLREASIM 641
>UniRef50_P43405 Cluster: Tyrosine-protein kinase SYK; n=23;
Theria|Rep: Tyrosine-protein kinase SYK - Homo sapiens
(Human)
Length = 635
Score = 31.9 bits (69), Expect = 6.9
Identities = 17/53 (32%), Positives = 27/53 (50%), Gaps = 1/53 (1%)
Query: 20 QQTKHYHIKQNSRGEFYLSDKHCCASIPELINYHKHNSGGLCSRLKATPCDRP 72
++ HY I++ G + ++ AS +L +YH S GL LK P +RP
Sbjct: 59 RKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLK-KPFNRP 110
>UniRef50_Q7Z1L9 Cluster: Neurite outgrowth regulated kinase; n=1;
Aplysia californica|Rep: Neurite outgrowth regulated
kinase - Aplysia californica (California sea hare)
Length = 991
Score = 31.5 bits (68), Expect = 9.1
Identities = 17/62 (27%), Positives = 29/62 (46%), Gaps = 3/62 (4%)
Query: 82 DKWEIDPSELVLMEVLGAGQFXXXXXXXXXXXIDTAVKMMKEGT--MSEDDFIDEAKVMT 139
D+WE+DP L +LG G F A+K+++EG ++D + E +M
Sbjct: 577 DEWELDPHSLKFSTLLGQGAFGKVVTGYYEDQ-KVAIKIVREGAPLSYKEDLVAEINLMK 635
Query: 140 SV 141
+
Sbjct: 636 RI 637
>UniRef50_A3EXK5 Cluster: Fibroblast growth factor receptor b; n=1;
Nematostella vectensis|Rep: Fibroblast growth factor
receptor b - Nematostella vectensis
Length = 591
Score = 31.5 bits (68), Expect = 9.1
Identities = 22/79 (27%), Positives = 36/79 (45%), Gaps = 8/79 (10%)
Query: 82 DKWEIDPSELVLMEVLGAGQFXXXXXXXXX------XXIDTAVKMMKEGTMSED--DFID 133
++WE+D S++ L+ +LG G F + AVKM+ E + D +
Sbjct: 265 EEWELDRSQISLLGILGEGAFGRVVKADAIGLPNMPYRCNVAVKMLXEDATEHELADLVS 324
Query: 134 EAKVMTSVYYLSIHINKIG 152
E +VM ++ IN IG
Sbjct: 325 EMEVMKTIGQHVNIINLIG 343
>UniRef50_Q07292 Cluster: Raf homolog serine/threonine-protein
kinase; n=5; Caenorhabditis|Rep: Raf homolog
serine/threonine-protein kinase - Caenorhabditis elegans
Length = 813
Score = 31.5 bits (68), Expect = 9.1
Identities = 13/32 (40%), Positives = 19/32 (59%), Gaps = 1/32 (3%)
Query: 71 RPAPPTAGLSHDKWEIDPSELVLMEVLGAGQF 102
RP PP H+ WEI P+E ++ +G+G F
Sbjct: 462 RPRPPQKP-HHEDWEILPNEFIIQYKVGSGSF 492
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.317 0.133 0.395
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 168,181,972
Number of Sequences: 1657284
Number of extensions: 6276909
Number of successful extensions: 14088
Number of sequences better than 10.0: 93
Number of HSP's better than 10.0 without gapping: 50
Number of HSP's successfully gapped in prelim test: 43
Number of HSP's that attempted gapping in prelim test: 13964
Number of HSP's gapped (non-prelim): 110
length of query: 159
length of database: 575,637,011
effective HSP length: 94
effective length of query: 65
effective length of database: 419,852,315
effective search space: 27290400475
effective search space used: 27290400475
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
S2: 68 (31.5 bits)
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