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Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= BGIBMGA000958-TA|BGIBMGA000958-PA|IPR002524|Cation efflux
protein, IPR009061|Putative DNA binding
         (436 letters)

Database: uniref50 
           1,657,284 sequences; 575,637,011 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_A1Z935 Cluster: CG8632-PB, isoform B; n=9; Endopterygot...   549   e-155
UniRef50_Q6PML9 Cluster: Zinc transporter 9; n=33; Eumetazoa|Rep...   502   e-140
UniRef50_UPI0000E4758C Cluster: PREDICTED: similar to Solute car...   477   e-133
UniRef50_Q3V5J4 Cluster: Putative uncharacterized protein; n=3; ...   284   3e-75
UniRef50_A7Q458 Cluster: Chromosome chr9 scaffold_49, whole geno...   264   2e-69
UniRef50_Q8H1G3 Cluster: Metal tolerance protein C4; n=3; Magnol...   255   2e-66
UniRef50_Q01GU4 Cluster: Membrane protein HUEL; n=2; Ostreococcu...   238   2e-61
UniRef50_Q4RTG8 Cluster: Chromosome 1 SCAF14998, whole genome sh...   234   4e-60
UniRef50_A6G134 Cluster: Predicted Co/Zn/Cd cation transporter; ...   220   7e-56
UniRef50_A6C709 Cluster: Cation efflux protein; n=1; Planctomyce...   200   4e-50
UniRef50_A0M1Q8 Cluster: CDF family cation efflux protein; n=1; ...   176   1e-42
UniRef50_Q1Q491 Cluster: Putative uncharacterized protein; n=1; ...   163   1e-38
UniRef50_Q2SF35 Cluster: Predicted Co/Zn/Cd cation transporters;...   156   9e-37
UniRef50_Q3JA92 Cluster: Cation efflux protein; n=4; Bacteria|Re...   156   1e-36
UniRef50_Q1QCT7 Cluster: Cation diffusion facilitator family tra...   156   1e-36
UniRef50_Q0F0R3 Cluster: Predicted Co/Zn/Cd cation transporters;...   150   8e-35
UniRef50_Q98D48 Cluster: Mll4860 protein; n=10; Proteobacteria|R...   146   1e-33
UniRef50_A6EC28 Cluster: Predicted Co/Zn/Cd cation transporter; ...   145   2e-33
UniRef50_A3IUW6 Cluster: Predicted Co/Zn/Cd cation transporters;...   144   5e-33
UniRef50_A1SQA1 Cluster: Cation diffusion facilitator family tra...   144   5e-33
UniRef50_Q0BR38 Cluster: Cobalt-zinc-cadmium resistance protein ...   142   2e-32
UniRef50_Q9L081 Cluster: Putative membrane transport protein; n=...   141   4e-32
UniRef50_A5V609 Cluster: Cation diffusion facilitator family tra...   140   7e-32
UniRef50_Q6A747 Cluster: Cation transport protein; n=1; Propioni...   134   6e-30
UniRef50_A6W6F7 Cluster: Cation diffusion facilitator family tra...   133   1e-29
UniRef50_Q6AHA9 Cluster: Cation transporter; n=1; Leifsonia xyli...   132   2e-29
UniRef50_A0GH18 Cluster: Cation diffusion facilitator family tra...   129   2e-28
UniRef50_A5P265 Cluster: Cation diffusion facilitator family tra...   124   3e-27
UniRef50_A7D914 Cluster: Cation diffusion facilitator family tra...   122   2e-26
UniRef50_A2XRM0 Cluster: Putative uncharacterized protein; n=1; ...   120   1e-25
UniRef50_Q2JCE5 Cluster: Cation diffusion facilitator family tra...   118   4e-25
UniRef50_Q825J3 Cluster: Putative transport protein; n=4; Strept...   117   7e-25
UniRef50_A4J438 Cluster: Cation diffusion facilitator family tra...   116   2e-24
UniRef50_Q3IUM9 Cluster: Transporter 37; n=1; Natronomonas phara...   115   3e-24
UniRef50_Q5UZ15 Cluster: Cation efflux protein; n=1; Haloarcula ...   112   2e-23
UniRef50_Q5FU46 Cluster: Cation efflux system protein; n=1; Gluc...    95   4e-18
UniRef50_Q838Z8 Cluster: Cation efflux family protein; n=4; Lact...    93   2e-17
UniRef50_A1A1Q0 Cluster: Cation transporter; n=3; Bifidobacteriu...    91   7e-17
UniRef50_A5ZXZ3 Cluster: Putative uncharacterized protein; n=1; ...    83   1e-14
UniRef50_Q5UX98 Cluster: Cation efflux system protein; n=3; Halo...    81   7e-14
UniRef50_A5FSC2 Cluster: Cation diffusion facilitator family tra...    80   1e-13
UniRef50_Q92AW3 Cluster: Lin1805 protein; n=17; Bacillales|Rep: ...    79   2e-13
UniRef50_A0DMX0 Cluster: Chromosome undetermined scaffold_57, wh...    76   2e-12
UniRef50_UPI00006CBFC4 Cluster: cation efflux family protein; n=...    74   6e-12
UniRef50_A0KRS9 Cluster: Cation diffusion facilitator family tra...    72   3e-11
UniRef50_Q3IQA7 Cluster: Transporter 38; n=1; Natronomonas phara...    66   2e-09
UniRef50_A6NR09 Cluster: Putative uncharacterized protein; n=1; ...    64   7e-09
UniRef50_A6DS63 Cluster: MMT1 protein; n=1; Lentisphaera araneos...    64   7e-09
UniRef50_O28143 Cluster: Conserved hypothetical transmembrane pr...    63   1e-08
UniRef50_A1THH9 Cluster: Cation diffusion facilitator family tra...    62   2e-08
UniRef50_P74068 Cluster: Uncharacterized transporter sll1263; n=...    62   3e-08
UniRef50_A4EAI9 Cluster: Putative uncharacterized protein; n=1; ...    60   9e-08
UniRef50_Q2SCG7 Cluster: Predicted Co/Zn/Cd cation transporters;...    60   1e-07
UniRef50_A6VZC2 Cluster: Cation diffusion facilitator family tra...    60   1e-07
UniRef50_A4E9J2 Cluster: Putative uncharacterized protein; n=1; ...    60   1e-07
UniRef50_Q8VLX7 Cluster: CzrB protein; n=3; Thermus thermophilus...    59   2e-07
UniRef50_A7AEG5 Cluster: Putative uncharacterized protein; n=1; ...    59   3e-07
UniRef50_Q8Y4L4 Cluster: Lmo2423 protein; n=14; Bacillales|Rep: ...    58   3e-07
UniRef50_Q6MQU1 Cluster: Cation efflux system protein; n=1; Bdel...    58   3e-07
UniRef50_A6TSV8 Cluster: Cation diffusion facilitator family tra...    58   3e-07
UniRef50_Q57891 Cluster: Uncharacterized transporter MJ0449; n=4...    58   3e-07
UniRef50_Q2BDX4 Cluster: Putative uncharacterized protein; n=2; ...    58   5e-07
UniRef50_A4J2G0 Cluster: Cation diffusion facilitator family tra...    58   5e-07
UniRef50_Q97K27 Cluster: Cation efflux system protein; n=1; Clos...    58   6e-07
UniRef50_Q8RDD5 Cluster: Predicted Co/Zn/Cd cation transporters;...    58   6e-07
UniRef50_A7CAR0 Cluster: Cation diffusion facilitator family tra...    57   8e-07
UniRef50_A1AWZ0 Cluster: Cation diffusion facilitator family tra...    57   8e-07
UniRef50_A1SH46 Cluster: Cation diffusion facilitator family tra...    57   1e-06
UniRef50_A1K3F1 Cluster: Putative cobalt-zinc-cadmium resistance...    57   1e-06
UniRef50_Q97LF5 Cluster: C-terminal region cation efflux system ...    56   1e-06
UniRef50_A7GZD1 Cluster: MMT1 protein; n=1; Campylobacter curvus...    56   1e-06
UniRef50_Q0W2J0 Cluster: Predicted cation efflux protein; n=3; E...    56   1e-06
UniRef50_Q837I0 Cluster: Cation efflux family protein; n=1; Ente...    56   2e-06
UniRef50_Q6A6E4 Cluster: Predicted Co/Zn/Cd cation transporter; ...    56   2e-06
UniRef50_Q6NE50 Cluster: Magnetosome protein MamB; n=5; Magnetos...    56   2e-06
UniRef50_A1WC43 Cluster: Cation diffusion facilitator family tra...    56   2e-06
UniRef50_A0KQ43 Cluster: Cation efflux family protein; n=2; Aero...    56   2e-06
UniRef50_Q98HP4 Cluster: Mlr2775 protein; n=12; Bacteria|Rep: Ml...    55   3e-06
UniRef50_A5EV87 Cluster: Cation efflux family protein; n=1; Dich...    55   3e-06
UniRef50_A5KR43 Cluster: Putative uncharacterized protein; n=2; ...    54   6e-06
UniRef50_A0NZQ3 Cluster: Cation efflux transporter, CDF family p...    54   6e-06
UniRef50_Q83BX5 Cluster: Cation-efflux family protein; n=2; Coxi...    54   7e-06
UniRef50_A6F284 Cluster: Predicted Co/Zn/Cd cation transporter; ...    54   7e-06
UniRef50_Q4IXC3 Cluster: Cation efflux protein; n=18; Pseudomona...    54   1e-05
UniRef50_Q3E481 Cluster: Cation efflux protein; n=5; Bacteria|Re...    54   1e-05
UniRef50_Q1LHU8 Cluster: Cation diffusion facilitator family tra...    53   1e-05
UniRef50_A6PM43 Cluster: Cation diffusion facilitator family tra...    53   1e-05
UniRef50_Q65T10 Cluster: MMT1 protein; n=1; Mannheimia succinici...    53   2e-05
UniRef50_Q11X42 Cluster: Cation efflux system protein; n=8; Bact...    53   2e-05
UniRef50_A6BDG0 Cluster: Putative uncharacterized protein; n=2; ...    53   2e-05
UniRef50_A3VV32 Cluster: Cation efflux family protein; n=1; Parv...    53   2e-05
UniRef50_A1BEH5 Cluster: Cation diffusion facilitator family tra...    53   2e-05
UniRef50_Q6LZI4 Cluster: Cation efflux protein; n=11; cellular o...    53   2e-05
UniRef50_O30282 Cluster: Conserved hypothetical transmembrane pr...    53   2e-05
UniRef50_Q479I8 Cluster: Cation efflux protein; n=1; Dechloromon...    52   2e-05
UniRef50_Q83PD6 Cluster: Cation-efflux pump fieF; n=70; Gammapro...    52   2e-05
UniRef50_Q9A2C4 Cluster: Cation efflux family protein; n=4; Alph...    52   3e-05
UniRef50_Q18YB5 Cluster: Cation diffusion facilitator family tra...    52   3e-05
UniRef50_Q0BW07 Cluster: Cobalt-zinc-cadmium resistance protein ...    52   3e-05
UniRef50_A3CXT0 Cluster: Cation diffusion facilitator family tra...    52   3e-05
UniRef50_Q0KAF7 Cluster: Cobalt-zinc-cadmium resistance protein ...    52   4e-05
UniRef50_Q1EYD3 Cluster: Cation efflux protein precursor; n=1; C...    51   5e-05
UniRef50_A6ECE5 Cluster: Cation efflux protein; n=1; Pedobacter ...    51   5e-05
UniRef50_Q8PTD7 Cluster: Cobalt-zinc-cadmium resistance protein;...    51   7e-05
UniRef50_UPI0000383D2E Cluster: COG0053: Predicted Co/Zn/Cd cati...    50   9e-05
UniRef50_Q5P2F7 Cluster: Putative uncharacterized protein; n=1; ...    50   9e-05
UniRef50_P96691 Cluster: YdfM protein; n=2; Bacillus|Rep: YdfM p...    50   9e-05
UniRef50_Q0AY41 Cluster: Putative cation efflux system protein; ...    50   9e-05
UniRef50_A5Z978 Cluster: Putative uncharacterized protein; n=2; ...    50   9e-05
UniRef50_Q7NKM3 Cluster: Gll1454 protein; n=3; Bacteria|Rep: Gll...    50   1e-04
UniRef50_A3XEG4 Cluster: Cation efflux system protein; n=9; Prot...    50   1e-04
UniRef50_A5ULB6 Cluster: Cation efflux system protein; n=1; Meth...    50   1e-04
UniRef50_Q3AES4 Cluster: Cation efflux family protein; n=1; Carb...    50   2e-04
UniRef50_Q9KDH5 Cluster: Cation efflux system; n=4; Bacillaceae|...    49   2e-04
UniRef50_Q2JWZ6 Cluster: Cation transporter, cation diffusion fa...    49   2e-04
UniRef50_Q565Y9 Cluster: Predicted Co/Zn/Cd cation transporter; ...    49   2e-04
UniRef50_A3X492 Cluster: Cation efflux transporter, CDF family p...    49   2e-04
UniRef50_A7DRF6 Cluster: Cation diffusion facilitator family tra...    49   2e-04
UniRef50_Q2W8Q4 Cluster: Predicted Co/Zn/Cd cation transporters;...    49   3e-04
UniRef50_Q2W8P3 Cluster: Predicted Co/Zn/Cd cation transporters;...    49   3e-04
UniRef50_O85143 Cluster: Transport protein; n=35; Bacteria|Rep: ...    49   3e-04
UniRef50_A5FYR2 Cluster: Cation diffusion facilitator family tra...    49   3e-04
UniRef50_Q5ZTX4 Cluster: Cation efflux family protein; n=4; Legi...    48   4e-04
UniRef50_A7GZ19 Cluster: Pantothenate metabolism flavoprotein; n...    48   4e-04
UniRef50_Q3A4F2 Cluster: Putative transport system permease prot...    48   5e-04
UniRef50_Q01VH6 Cluster: Cation diffusion facilitator family tra...    48   5e-04
UniRef50_A1WYJ4 Cluster: Cation diffusion facilitator family tra...    48   5e-04
UniRef50_A1HSL0 Cluster: Cation diffusion facilitator family tra...    48   5e-04
UniRef50_Q5LTM6 Cluster: Cation efflux system protein; n=13; Alp...    48   6e-04
UniRef50_Q6QSW0 Cluster: Cation efflux facilitator; n=1; Enteroc...    48   6e-04
UniRef50_Q03ZB0 Cluster: Co/Zn/Cd efflux system component; n=1; ...    48   6e-04
UniRef50_Q8KEZ4 Cluster: Cation efflux family protein; n=6; Chlo...    47   8e-04
UniRef50_A7HL40 Cluster: Cation diffusion facilitator family tra...    47   8e-04
UniRef50_A1VH99 Cluster: Cation diffusion facilitator family tra...    47   8e-04
UniRef50_Q311T6 Cluster: Cation diffusion facilitator family tra...    47   0.001
UniRef50_A6CU38 Cluster: Cation efflux family protein; probable ...    47   0.001
UniRef50_A3CRV2 Cluster: Cation diffusion facilitator family tra...    47   0.001
UniRef50_Q9KEY7 Cluster: Cation efflux system; n=11; Bacillus|Re...    46   0.001
UniRef50_Q57BV0 Cluster: Cation efflux family protein; n=9; Rhiz...    46   0.001
UniRef50_Q2RHV4 Cluster: Cation diffusion facilitator family tra...    46   0.001
UniRef50_A3ZLV0 Cluster: Putative uncharacterized protein; n=1; ...    46   0.002
UniRef50_A3EVG9 Cluster: Putative Co/Zn/Cd cation transporter; n...    46   0.002
UniRef50_A1TZF9 Cluster: Cation diffusion facilitator family tra...    46   0.002
UniRef50_Q5L2G4 Cluster: Cation efflux transporter; n=5; Bacilla...    46   0.003
UniRef50_Q1NQB8 Cluster: Cation efflux protein; n=2; delta prote...    46   0.003
UniRef50_A6LXL8 Cluster: Cation diffusion facilitator family tra...    46   0.003
UniRef50_A1SZS2 Cluster: Iron and zinc efflux system protein; n=...    46   0.003
UniRef50_A0AWY3 Cluster: Cation diffusion facilitator family tra...    46   0.003
UniRef50_Q5ZR77 Cluster: Putative uncharacterized protein R02F11...    46   0.003
UniRef50_Q6MCR1 Cluster: Putative cation efflux system protein; ...    45   0.003
UniRef50_Q2AI61 Cluster: Cation efflux protein; n=1; Halothermot...    45   0.003
UniRef50_A0YFC6 Cluster: Cation transporter, cation diffusion fa...    45   0.003
UniRef50_A0V364 Cluster: Cation diffusion facilitator family tra...    45   0.003
UniRef50_O27240 Cluster: Possible cation transporter; n=1; Metha...    45   0.003
UniRef50_Q1AYG3 Cluster: Cation diffusion facilitator family tra...    45   0.005
UniRef50_A1VZU0 Cluster: Cation efflux family protein; n=12; Cam...    45   0.005
UniRef50_P46348 Cluster: Uncharacterized transporter yeaB; n=19;...    45   0.005
UniRef50_Q62FW4 Cluster: Cation efflux family protein; n=48; Pro...    44   0.006
UniRef50_Q3VS68 Cluster: Cation efflux protein; n=2; Chlorobiace...    44   0.006
UniRef50_A3XRG5 Cluster: Cobalt/zinc/cadmium cation efflux pump ...    44   0.006
UniRef50_Q5D9U1 Cluster: SJCHGC08837 protein; n=1; Schistosoma j...    44   0.006
UniRef50_Q8CNH2 Cluster: CzrB protein; n=3; Staphylococcus|Rep: ...    44   0.008
UniRef50_Q5FQH9 Cluster: Cation efflux system protein; n=1; Gluc...    44   0.008
UniRef50_Q2BMX3 Cluster: Cation-efflux family protein; n=1; Nept...    44   0.008
UniRef50_A6LZH5 Cluster: Cation diffusion facilitator family tra...    44   0.008
UniRef50_A0LXC1 Cluster: CDF family cation efflux protein; n=3; ...    44   0.008
UniRef50_Q81QV5 Cluster: Cation efflux family protein; n=19; Fir...    44   0.010
UniRef50_A0LCE7 Cluster: Cation diffusion facilitator family tra...    44   0.010
UniRef50_Q5KK51 Cluster: Di-, tri-valent inorganic cation transp...    44   0.010
UniRef50_Q8TT22 Cluster: Cation efflux system protein; n=5; cell...    44   0.010
UniRef50_Q98H85 Cluster: Cation efflux system protein; n=8; Alph...    43   0.014
UniRef50_A6BIC1 Cluster: Putative uncharacterized protein; n=1; ...    43   0.014
UniRef50_Q8TT88 Cluster: Cation efflux system protein; n=4; Meth...    43   0.014
UniRef50_Q97PQ1 Cluster: Cation efflux family protein; n=41; Str...    43   0.018
UniRef50_Q7UMH1 Cluster: Cation efflux system protein; n=1; Pire...    43   0.018
UniRef50_Q74FW5 Cluster: Cation efflux family protein; n=7; Desu...    43   0.018
UniRef50_A6LME7 Cluster: Cation diffusion facilitator family tra...    43   0.018
UniRef50_A0LLF0 Cluster: Cation diffusion facilitator family tra...    43   0.018
UniRef50_A7I5F3 Cluster: Cation diffusion facilitator family tra...    43   0.018
UniRef50_Q67QQ7 Cluster: Cation efflux system protein; n=1; Symb...    42   0.024
UniRef50_A1VD81 Cluster: Cation diffusion facilitator family tra...    42   0.024
UniRef50_Q03218 Cluster: Mitochondrial metal transporter 1, mito...    42   0.024
UniRef50_A7CNS8 Cluster: Cation diffusion facilitator family tra...    42   0.032
UniRef50_A7BVM0 Cluster: Cation efflux protein; n=3; Beggiatoa s...    42   0.032
UniRef50_A4BEK1 Cluster: Predicted Co/Zn/Cd cation transporter; ...    42   0.032
UniRef50_Q97NZ2 Cluster: Cation efflux system protein; n=27; Str...    42   0.042
UniRef50_A0Y777 Cluster: Putative transport protein; n=3; Altero...    42   0.042
UniRef50_A0L9V8 Cluster: Cation diffusion facilitator family tra...    42   0.042
UniRef50_Q8ZYX3 Cluster: Cation efflux system protein, conjectur...    42   0.042
UniRef50_Q97MV4 Cluster: Predicted Co/Zn/Cd cation transporter; ...    41   0.056
UniRef50_A1IAH4 Cluster: Cation diffusion facilitator family tra...    41   0.056
UniRef50_Q8F433 Cluster: Cobalt-zinc-cadmium resistance protein ...    41   0.074
UniRef50_A5IIQ7 Cluster: Cation diffusion facilitator family tra...    41   0.074
UniRef50_A0Q5V4 Cluster: Predicted Co/Zn/Cd cation transporter; ...    41   0.074
UniRef50_A7SP61 Cluster: Predicted protein; n=1; Nematostella ve...    41   0.074
UniRef50_Q9PF12 Cluster: Cobalt-zinc-cadmium resistance protein;...    40   0.097
UniRef50_Q6AS02 Cluster: Conserved hypothetical membrane protein...    40   0.097
UniRef50_A3ERL9 Cluster: Putative Co/Zn/Cd cation transporter; n...    40   0.097
UniRef50_A0L9W4 Cluster: Cation diffusion facilitator family tra...    40   0.097
UniRef50_A6UWS0 Cluster: Cation diffusion facilitator family tra...    40   0.097
UniRef50_Q8L725 Cluster: Metal tolerance protein C1; n=2; Arabid...    40   0.097
UniRef50_Q2PY00 Cluster: Nucleoside transporter; n=1; uncultured...    40   0.13 
UniRef50_Q036T5 Cluster: Predicted Co/Zn/Cd cation transporter; ...    40   0.13 
UniRef50_A6EF02 Cluster: Cation efflux system protein; n=1; Pedo...    40   0.13 
UniRef50_A6CGW2 Cluster: Putative cation efflux system protein; ...    40   0.13 
UniRef50_A4M6M7 Cluster: Cation diffusion facilitator family tra...    40   0.13 
UniRef50_A4IN96 Cluster: Cation efflux family protein; n=3; Baci...    40   0.13 
UniRef50_A3DKT1 Cluster: Cation diffusion facilitator family tra...    40   0.13 
UniRef50_Q607F9 Cluster: Cation efflux family protein; n=7; Bact...    40   0.17 
UniRef50_A5WCY6 Cluster: Cation diffusion facilitator family tra...    40   0.17 
UniRef50_A1ZDC5 Cluster: Heavy metal efflux pump, CzcD family; n...    40   0.17 
UniRef50_A3H9P4 Cluster: Cation diffusion facilitator family tra...    40   0.17 
UniRef50_Q6D7E5 Cluster: Zinc transporter zitB; n=40; Enterobact...    40   0.17 
UniRef50_Q12263 Cluster: Serine/threonine-protein kinase GIN4; n...    40   0.17 
UniRef50_Q2NTU9 Cluster: Putative transport protein; n=1; Sodali...    39   0.22 
UniRef50_O67851 Cluster: Putative uncharacterized protein; n=1; ...    39   0.22 
UniRef50_A0VV15 Cluster: Cation diffusion facilitator family tra...    39   0.22 
UniRef50_UPI0000499CA1 Cluster: cation diffusion facilitator fam...    39   0.30 
UniRef50_Q3AYC0 Cluster: Cation efflux protein; n=13; Cyanobacte...    39   0.30 
UniRef50_Q2NBG7 Cluster: Cation efflux system protein; n=3; Prot...    39   0.30 
UniRef50_A5TUV7 Cluster: Possible CDF family cation diffusion fa...    39   0.30 
UniRef50_A1W8N6 Cluster: Putative uncharacterized protein; n=3; ...    39   0.30 
UniRef50_A1D9L0 Cluster: Di-, tri-valent inorganic cation transp...    39   0.30 
UniRef50_Q8TV30 Cluster: Predicted Co/Zn/Cd cation transporter; ...    39   0.30 
UniRef50_Q7MT89 Cluster: Cation efflux family protein; n=3; Bact...    38   0.39 
UniRef50_Q3ZWB7 Cluster: Cation efflux family protein; n=2; Deha...    38   0.39 
UniRef50_Q1IPF4 Cluster: Cation diffusion facilitator family tra...    38   0.39 
UniRef50_A3UGA9 Cluster: Cation efflux protein; n=3; Proteobacte...    38   0.39 
UniRef50_A4HFQ2 Cluster: Cation transporter, putative; n=3; Leis...    38   0.39 
UniRef50_Q6CT16 Cluster: Kluyveromyces lactis strain NRRL Y-1140...    38   0.39 
UniRef50_Q0CAH3 Cluster: Predicted protein; n=1; Aspergillus ter...    38   0.39 
UniRef50_Q8TP38 Cluster: Cation efflux system protein; n=3; Meth...    38   0.39 
UniRef50_A0RND9 Cluster: Ferrous-iron efflux pump FieF; n=1; Cam...    38   0.52 
UniRef50_A0IKN6 Cluster: Cation diffusion facilitator family tra...    38   0.52 
UniRef50_Q7NIC0 Cluster: Gll2263 protein; n=2; Cyanobacteria|Rep...    38   0.69 
UniRef50_Q749X9 Cluster: Cation efflux family protein; n=8; Delt...    38   0.69 
UniRef50_Q6LGB2 Cluster: Hypothetical cation-efflux family prote...    38   0.69 
UniRef50_Q2S288 Cluster: Cation efflux family protein; n=1; Sali...    38   0.69 
UniRef50_Q2LWF9 Cluster: Co/Zn/Cd cation transporter; n=1; Syntr...    38   0.69 
UniRef50_A5G751 Cluster: Cation diffusion facilitator family tra...    38   0.69 
UniRef50_A3TRN3 Cluster: Tyrosine protein kinase:Serine/threonin...    38   0.69 
UniRef50_A0LKX9 Cluster: Cation diffusion facilitator family tra...    38   0.69 
UniRef50_Q4WLB1 Cluster: CDF zinc transporter (Msc2), putaitve; ...    38   0.69 
UniRef50_Q2FN36 Cluster: Cation diffusion facilitator family tra...    38   0.69 
UniRef50_O27915 Cluster: Cation efflux system protein; n=1; Meth...    38   0.69 
UniRef50_A5UNR6 Cluster: Heavy metal cation (Co/Zn/Cd) efflux sy...    38   0.69 
UniRef50_Q08970 Cluster: Mitochondrial metal transporter 2, mito...    38   0.69 
UniRef50_UPI0000DAE7E5 Cluster: hypothetical protein Rgryl_01001...    37   0.91 
UniRef50_Q8FU00 Cluster: Putative uncharacterized protein; n=1; ...    37   0.91 
UniRef50_Q606W3 Cluster: Cation efflux family protein; n=2; Bact...    37   0.91 
UniRef50_Q1GPY2 Cluster: Cation diffusion facilitator family tra...    37   0.91 
UniRef50_Q11N98 Cluster: HflK protein; n=1; Mesorhizobium sp. BN...    37   0.91 
UniRef50_A0QIJ5 Cluster: Cation efflux family protein; n=3; Myco...    37   0.91 
UniRef50_A7I6Y5 Cluster: Cation diffusion facilitator family tra...    37   0.91 
UniRef50_Q97G32 Cluster: Co/Zn/Cd efflux system component; n=1; ...    37   1.2  
UniRef50_Q67K51 Cluster: Cation efflux system protein; n=1; Symb...    37   1.2  
UniRef50_Q1Q6L8 Cluster: Putative uncharacterized protein; n=1; ...    37   1.2  
UniRef50_A5G746 Cluster: Cation diffusion facilitator family tra...    37   1.2  
UniRef50_Q20864 Cluster: Putative uncharacterized protein; n=2; ...    37   1.2  
UniRef50_Q8Q0G9 Cluster: Cobalt-zinc-cadmium resistance protein;...    37   1.2  
UniRef50_Q6ML10 Cluster: Cation-efflux system membrane protein; ...    36   1.6  
UniRef50_Q1K0N1 Cluster: Cation diffusion facilitator family tra...    36   1.6  
UniRef50_A0B5Z8 Cluster: Cation diffusion facilitator family tra...    36   1.6  
UniRef50_Q6NHN1 Cluster: Cation-efflux system integral membrane ...    36   2.1  
UniRef50_Q64SU7 Cluster: Cation efflux system protein; n=5; Bact...    36   2.1  
UniRef50_Q07XG6 Cluster: Cation diffusion facilitator family tra...    36   2.1  
UniRef50_A6E8Q8 Cluster: Mg/Co/Ni transporter; n=1; Pedobacter s...    36   2.1  
UniRef50_A0RLZ7 Cluster: Cation efflux family protein; n=1; Camp...    36   2.1  
UniRef50_Q5B283 Cluster: Putative uncharacterized protein; n=1; ...    36   2.1  
UniRef50_UPI0000DD81FD Cluster: PREDICTED: hypothetical protein;...    36   2.8  
UniRef50_A6LYH8 Cluster: Cation diffusion facilitator family tra...    36   2.8  
UniRef50_A4JL20 Cluster: Filamentous haemagglutinin family outer...    36   2.8  
UniRef50_A1AW34 Cluster: Acriflavin resistance protein precursor...    36   2.8  
UniRef50_UPI0000D560E9 Cluster: PREDICTED: similar to CG6358-PA;...    35   3.7  
UniRef50_Q7M8H2 Cluster: TRANSMEMBRANE TRANSPORT PROTEIN-Predict...    35   3.7  
UniRef50_Q5HLH9 Cluster: Cation efflux family protein; n=16; Sta...    35   3.7  
UniRef50_Q5FM42 Cluster: Cation efflux protein; n=5; Lactobacill...    35   3.7  
UniRef50_Q0EXM1 Cluster: Outer membrane efflux protein; n=1; Mar...    35   3.7  
UniRef50_A3VSL3 Cluster: Cation efflux protein; n=1; Parvularcul...    35   3.7  
UniRef50_A3TMJ1 Cluster: Putative uncharacterized protein; n=1; ...    35   3.7  
UniRef50_Q54T06 Cluster: Cation efflux family protein; n=1; Dict...    35   3.7  
UniRef50_Q4D6N1 Cluster: Cation transporter protein, putative; n...    35   3.7  
UniRef50_A7D284 Cluster: Phosphate transporter precursor; n=1; H...    35   3.7  
UniRef50_A1S0U9 Cluster: Cation diffusion facilitator family tra...    35   3.7  
UniRef50_P17622 Cluster: Protein ribT; n=20; Bacillaceae|Rep: Pr...    35   3.7  
UniRef50_Q7NRV3 Cluster: Probable cation efflux system; n=1; Chr...    35   4.8  
UniRef50_Q6N8G4 Cluster: Possible cation efflux protein precurso...    35   4.8  
UniRef50_Q57CG8 Cluster: DedA family protein; n=7; Rhizobiales|R...    35   4.8  
UniRef50_A6SYW0 Cluster: Cobalt-zinc-cadmium resistance protein ...    35   4.8  
UniRef50_A4FNS2 Cluster: Transcriptional regulator, DeoR family;...    35   4.8  
UniRef50_P93574 Cluster: 123.pep; n=4; Magnoliophyta|Rep: 123.pe...    35   4.8  
UniRef50_A7PMH0 Cluster: Chromosome chr14 scaffold_21, whole gen...    35   4.8  
UniRef50_A2WK96 Cluster: Putative uncharacterized protein; n=2; ...    35   4.8  
UniRef50_Q5CY80 Cluster: Hypothetical low complexity protein per...    35   4.8  
UniRef50_Q8TRQ7 Cluster: Cation efflux system protein; n=2; Meth...    35   4.8  
UniRef50_P23025 Cluster: DNA-repair protein complementing XP-A c...    35   4.8  
UniRef50_UPI00015B5386 Cluster: PREDICTED: similar to GA21362-PA...    34   6.4  
UniRef50_Q62KE9 Cluster: Drug resistance transporter, EmrB/QacA ...    34   6.4  
UniRef50_Q30S31 Cluster: Cation efflux protein; n=1; Thiomicrosp...    34   6.4  
UniRef50_Q1NK31 Cluster: BCCT transporter precursor; n=3; cellul...    34   6.4  
UniRef50_Q04D37 Cluster: Co/Zn/Cd efflux system component; n=2; ...    34   6.4  
UniRef50_A7HGB0 Cluster: Transport system permease protein; n=4;...    34   6.4  
UniRef50_A1SPC8 Cluster: Putative uncharacterized protein; n=1; ...    34   6.4  
UniRef50_Q16R73 Cluster: DNA-repair protein complementing XP-A c...    34   6.4  
UniRef50_Q0TYP1 Cluster: Putative uncharacterized protein; n=1; ...    34   6.4  
UniRef50_Q64267 Cluster: DNA-repair protein complementing XP-A c...    34   6.4  
UniRef50_Q97LI8 Cluster: Predicted membrane protein; n=1; Clostr...    34   8.4  
UniRef50_Q7UM65 Cluster: Putative uncharacterized protein; n=1; ...    34   8.4  
UniRef50_Q1YHC7 Cluster: Possible integral membrane protein; n=2...    34   8.4  
UniRef50_Q0SDQ6 Cluster: Na(+):solute symporter, SSF family prot...    34   8.4  
UniRef50_Q032C1 Cluster: Predicted Co/Zn/Cd cation transporter; ...    34   8.4  
UniRef50_A5CV52 Cluster: Hypothetical membrane protein; n=1; Cla...    34   8.4  

>UniRef50_A1Z935 Cluster: CG8632-PB, isoform B; n=9;
           Endopterygota|Rep: CG8632-PB, isoform B - Drosophila
           melanogaster (Fruit fly)
          Length = 660

 Score =  549 bits (1356), Expect = e-155
 Identities = 265/440 (60%), Positives = 333/440 (75%), Gaps = 6/440 (1%)

Query: 2   RAMTEYLLKQSDLESLPKVLRRSPYESEPPITVYYRRDVEAKAIEIWGSKXXXXXXXXXX 61
           RA++++LL  + LESLPK+ RRSPYE EPP+TVY+RRDVEAKA+E+WGSK          
Sbjct: 222 RAISDFLLTAAQLESLPKIKRRSPYEQEPPMTVYWRRDVEAKAVEVWGSKENLLRERLKR 281

Query: 62  XXXXXXXXQ-----DVFTVKRRLRDYRREMSHTRSKDNVEEVGLKTRSGRVVLTAIGING 116
                   Q     D+FTVKRRLRDYRREM  +R+K  ++      +SG+VV TAI IN 
Sbjct: 282 EVERKQYQQIYDSADLFTVKRRLRDYRREMG-SRTKVMLDNRKESEKSGQVVATAIAINA 340

Query: 117 CNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYV 176
            N LFK   W Y+GSHS+F+E IHSLAD +NQLILA+GI+KS Q  D DHPYGY NMRYV
Sbjct: 341 ANLLFKAGGWLYSGSHSMFAEVIHSLADLINQLILAFGIYKSSQSPDIDHPYGYMNMRYV 400

Query: 177 SSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIR 236
           SSLISGVGIFCVG GLS YHG+ GIL P+P+ D +W Y +L G++VSEGATL+VA++ ++
Sbjct: 401 SSLISGVGIFCVGCGLSIYHGIDGILHPEPITDLFWVYCILMGSLVSEGATLVVAINELK 460

Query: 237 KGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSI 296
           + A+E NMS  +YV+   DP VNVVL ED AAV GV+VAA+CM +S YTG+P+ DA GS+
Sbjct: 461 RSAKENNMSFKDYVISGKDPCVNVVLCEDAAAVTGVMVAAACMGLSSYTGSPIFDAAGSL 520

Query: 297 LVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDVKGIDIGSNLI 356
           ++G +LG VASFII +N  ALVG SI  E+L++INS LE D MIRAI+DVKGIDIG+  +
Sbjct: 521 VIGALLGAVASFIIYTNANALVGISIASERLEKINSALEADVMIRAIYDVKGIDIGNARV 580

Query: 357 RYKAEVDFDGRALTRSYLEKHDLNALLEDMKKIDTIDDVETFLLKHGENIVDMLGGEIDR 416
           RYKAE+DFDGR LTRSYL+K DL  LL  ++    ++D+E+FLL  GENIVD++GGEIDR
Sbjct: 581 RYKAELDFDGRELTRSYLDKQDLAKLLTTVRGFQKVEDLESFLLDQGENIVDLMGGEIDR 640

Query: 417 IELKLRKKFPQIRHCDLEIL 436
           IE+ LR +FP+IRH DLEIL
Sbjct: 641 IEMNLRTQFPEIRHVDLEIL 660


>UniRef50_Q6PML9 Cluster: Zinc transporter 9; n=33; Eumetazoa|Rep:
           Zinc transporter 9 - Homo sapiens (Human)
          Length = 568

 Score =  502 bits (1237), Expect = e-140
 Identities = 236/436 (54%), Positives = 316/436 (72%), Gaps = 1/436 (0%)

Query: 1   MRAMTEYLLKQSDLESLPKVLRRSPYESEPPITVYYRRDVEAKAIEIWGSKXXXXXXXXX 60
           +RA+ E+ LK SDLE L K+ RRSP+E     TVY R DVEAK++E+WGS          
Sbjct: 134 VRAINEFCLKSSDLEQLRKIRRRSPHEDTESFTVYLRSDVEAKSLEVWGSPEALAREKKL 193

Query: 61  XXXXXXXXXQDVFTVKRRLRDYRREMSHTRSKDNVEEVGLKTRSGRVVLTAIGINGCNFL 120
                    + +F  ++ LR+YR  + +T+ +     V  K   G+VV+ AI ING N  
Sbjct: 194 RKEAEIEYRERLFRNQKILREYRDFLGNTKPRSRTASVFFKG-PGKVVMVAICINGLNCF 252

Query: 121 FKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLI 180
           FK  AW YTGS S+FSE IHSL+DT NQ +LA GI KSVQ  DP HPYG++NMRY+SSLI
Sbjct: 253 FKFLAWIYTGSASMFSEAIHSLSDTCNQGLLALGISKSVQTPDPSHPYGFSNMRYISSLI 312

Query: 181 SGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGAR 240
           SGVGIF +G+GLS+YHGV G+L PQP+    WAY +L G++VSEGATL+VA++ +R+ AR
Sbjct: 313 SGVGIFMMGAGLSWYHGVMGLLHPQPIESLLWAYCILAGSLVSEGATLLVAVNELRRNAR 372

Query: 241 EANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGT 300
              MS Y+YVM S DPS NV+LLEDTAAV GVI+AA+CM ++  TGNPL D+LGS+ VGT
Sbjct: 373 AKGMSFYKYVMESRDPSTNVILLEDTAAVLGVIIAATCMGLTSITGNPLYDSLGSLGVGT 432

Query: 301 ILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDVKGIDIGSNLIRYKA 360
           +LG V++F+I +N  AL+GRSI  EQ+  +  +LE D  +RAIHDVK  D+G   +R+KA
Sbjct: 433 LLGMVSAFLIYTNTEALLGRSIQPEQVQRLTELLENDPSVRAIHDVKATDLGLGKVRFKA 492

Query: 361 EVDFDGRALTRSYLEKHDLNALLEDMKKIDTIDDVETFLLKHGENIVDMLGGEIDRIELK 420
           EVDFDGR +TRSYLEK D + +L++++++ T +++ETF+LKHGENI+D LG E+DR+E +
Sbjct: 493 EVDFDGRVVTRSYLEKQDFDQMLQEIQEVKTPEELETFMLKHGENIIDTLGAEVDRLEKE 552

Query: 421 LRKKFPQIRHCDLEIL 436
           L+K+ P++RH DLEIL
Sbjct: 553 LKKRNPEVRHVDLEIL 568


>UniRef50_UPI0000E4758C Cluster: PREDICTED: similar to Solute
           carrier family 30 (zinc transporter), member 9; n=3;
           Strongylocentrotus purpuratus|Rep: PREDICTED: similar to
           Solute carrier family 30 (zinc transporter), member 9 -
           Strongylocentrotus purpuratus
          Length = 602

 Score =  477 bits (1177), Expect = e-133
 Identities = 227/439 (51%), Positives = 311/439 (70%), Gaps = 8/439 (1%)

Query: 1   MRAMTEYLLKQSDLESLPKVLRRSPYE---SEPPITVYYRRDVEAKAIEIWGSKXXXXXX 57
           +RAM++YLLK SDLE L K +RRSPY+   SE  + VY R DVE KAIEIWGS       
Sbjct: 169 VRAMSDYLLKSSDLEQLRKTVRRSPYDQESSERNMMVYLRSDVEQKAIEIWGSMDALEME 228

Query: 58  XXXXXXXXXXXXQDVFTVKRRLRDYRREMSHTRSKDNVEEVGLKTRSGRVVLTAIGINGC 117
                       + +F +KR +R+Y           ++ E      +G+VVL+AI IN  
Sbjct: 229 KKKRRERDAVYKEHLFLLKRAMREYDSFFGPKEPTPSIFE-----GAGQVVLSAIAINTG 283

Query: 118 NFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVS 177
           NF+FKL AW Y+GS S+FSE IHSLAD  NQ ILA GI++S +    +HPYG++NMR++S
Sbjct: 284 NFVFKLMAWLYSGSSSMFSEAIHSLADVCNQCILALGIYQSFKKPSRNHPYGFSNMRHIS 343

Query: 178 SLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRK 237
           SLISGVGIFCVG+GLSFYHG+TG+L P+P+   +W+Y +LGGA+++EGATL +A++AIRK
Sbjct: 344 SLISGVGIFCVGAGLSFYHGITGLLHPEPVQSLFWSYCILGGALLTEGATLSIAINAIRK 403

Query: 238 GAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSIL 297
           G+    M  ++YV R+ DPSVNVV +EDTAAV GVI+A SCM ++  TGNP+ D++G++ 
Sbjct: 404 GSTARKMKFWDYVWRARDPSVNVVFMEDTAAVIGVIIAGSCMGLTSITGNPMYDSIGALG 463

Query: 298 VGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDVKGIDIGSNLIR 357
           VGT+LG V+ F+I +N  AL GRSIP +QL +++ V+E D MIR ++DVK  D+G N IR
Sbjct: 464 VGTLLGAVSGFLIYTNTMALTGRSIPDDQLLKLSEVMENDVMIRGVYDVKATDMGVNTIR 523

Query: 358 YKAEVDFDGRALTRSYLEKHDLNALLEDMKKIDTIDDVETFLLKHGENIVDMLGGEIDRI 417
           +KAE+D DG  LTRSYL+  DL  +L++++    +++VE F+LKHGE I+D LG E+DRI
Sbjct: 524 FKAELDIDGAELTRSYLDTQDLEVILKEIQSFKNLEEVEYFMLKHGERIIDQLGAEVDRI 583

Query: 418 ELKLRKKFPQIRHCDLEIL 436
           E  ++   P++RH DLEIL
Sbjct: 584 EKLIKATDPEVRHVDLEIL 602


>UniRef50_Q3V5J4 Cluster: Putative uncharacterized protein; n=3;
           Caenorhabditis|Rep: Putative uncharacterized protein -
           Caenorhabditis elegans
          Length = 443

 Score =  284 bits (697), Expect = 3e-75
 Identities = 158/379 (41%), Positives = 224/379 (59%), Gaps = 18/379 (4%)

Query: 1   MRAMTEYLLKQSDLESLP---KVLRRSPYESEPPITVYYRRDVEAKAIEIWGSKXXXXXX 57
           + AM E+ LK+SDLE LP   K +    +  +    +Y   +V  KA+++ GS       
Sbjct: 71  LSAMAEFGLKESDLEDLPSHSKPVLSLTHHGKSNHQLYTLTEVYHKALKVHGS------- 123

Query: 58  XXXXXXXXXXXXQDVFTVKRRLRDYRREMSHTRSKDNVEEVGLKTRSGRVVLTAIGINGC 117
                       + +  +++ L D  R     R +  VE       + RVV  A  +N C
Sbjct: 124 ----TEALEAHRRPLVAMRKELTDAER----MRMRMRVETTNQHKGADRVVAIAFTLNLC 175

Query: 118 NFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVS 177
           +   K  A + TGS SLF+E IHS  DT NQLIL  GI  S +  D   PYGY NMRYV+
Sbjct: 176 DMAMKFTAAYLTGSKSLFAEAIHSAMDTCNQLILLLGIRYSAKNPDLLFPYGYGNMRYVT 235

Query: 178 SLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRK 237
           SLISG GI   G GLS YHG++G+L P+PL    +AY+ L  ++  +G + + A   +  
Sbjct: 236 SLISGCGIMAFGCGLSMYHGISGLLHPEPLEPLTYAYYALFMSLCFQGTSAITAYREVFA 295

Query: 238 GAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSIL 297
            A++AN+S++ YV  S+DPS+NVVLLEDTAAV GV +A   +++S +  +P+PD  GSI+
Sbjct: 296 KAKKANISIWNYVRTSADPSLNVVLLEDTAAVTGVGIALCAISLSSFLNSPIPDCCGSIV 355

Query: 298 VGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDVKGIDIGSNLIR 357
           +G +LG VASFII +N   LVGRS+P    D+I + L  D MIR++HDVK   +G    R
Sbjct: 356 IGALLGTVASFIIRTNAAHLVGRSLPQRITDDIVARLNNDPMIRSVHDVKATCLGVEQSR 415

Query: 358 YKAEVDFDGRALTRSYLEK 376
           +KAE+DFDGR +TR+YL++
Sbjct: 416 FKAELDFDGRMITRAYLQE 434


>UniRef50_A7Q458 Cluster: Chromosome chr9 scaffold_49, whole genome
           shotgun sequence; n=1; Vitis vinifera|Rep: Chromosome
           chr9 scaffold_49, whole genome shotgun sequence - Vitis
           vinifera (Grape)
          Length = 459

 Score =  264 bits (648), Expect = 2e-69
 Identities = 138/359 (38%), Positives = 212/359 (59%), Gaps = 5/359 (1%)

Query: 80  RDYRREMSHTRSKDNVEEVGLKTR-SGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSEC 138
           R Y      TR+K+ V+ + +  + S R V TA+  N   F  K   W  T SH + +E 
Sbjct: 93  RHYINRNFFTRAKE-VKNIEINDQHSQRAVRTALWCNFLVFSLKFGVWLTTSSHVMLAEV 151

Query: 139 IHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGV 198
           +HS AD  NQ +LAYG+  S +  D  HPYGY+  R+V SLIS VGIFC+GSG +  HGV
Sbjct: 152 VHSAADFANQALLAYGLSSSRRAPDAIHPYGYSKERFVWSLISAVGIFCLGSGATIVHGV 211

Query: 199 TGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSV 258
             +    P  +  +A  V+GG+ + EGA+L+VA+ A++KGA    M + +YV R  DP+ 
Sbjct: 212 QNLWTSHPPANIQYAALVIGGSFLIEGASLVVAIHAVKKGAAAEGMKVRDYVWRGHDPTS 271

Query: 259 NVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALV 318
             V+ ED AAV G+I+A + +     TGNP+ D +GSI+VG +LG VA F+I  N  AL+
Sbjct: 272 VAVMTEDGAAVTGLIIAGASLVAVNTTGNPIYDPIGSIVVGNLLGMVAIFLIQRNRHALI 331

Query: 319 GRSIPHEQLDEINSVLERDFMIRAIHDVKGIDIGSNLIRYKAEVDFDGRALTRSYLEKHD 378
           GR+I    ++++ ++L+ D ++ A++D K   IG    R+KAE+DF+G  + ++YL++  
Sbjct: 332 GRAIDAHDMEKVLNLLKNDPVVDALYDCKSEVIGPGFFRFKAEIDFNGVVVVQNYLKRTG 391

Query: 379 LNALLEDMKKIDTIDDVETFL---LKHGENIVDMLGGEIDRIELKLRKKFPQIRHCDLE 434
                   ++    +D    L     +GE +V  LG E+DR+E ++++  P IRH D+E
Sbjct: 392 RETWARQFREAAKEEDDSALLRMMSNYGEEVVTALGSEVDRLEKEIQELVPGIRHVDIE 450


>UniRef50_Q8H1G3 Cluster: Metal tolerance protein C4; n=3;
           Magnoliophyta|Rep: Metal tolerance protein C4 -
           Arabidopsis thaliana (Mouse-ear cress)
          Length = 457

 Score =  255 bits (624), Expect = 2e-66
 Identities = 129/350 (36%), Positives = 213/350 (60%), Gaps = 5/350 (1%)

Query: 89  TRSKDNVEEVGLKTR-SGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVN 147
           TR+K  V+ + +  + S R V TA+  N   F  K   W+ + SH + +E +HS+AD  N
Sbjct: 98  TRAKQ-VKRIEINDQHSQRAVTTALWCNFLVFSLKFGVWWTSSSHVIMAEVVHSVADFAN 156

Query: 148 QLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPL 207
           Q +LAYG+  S +  D  HPYGY+  R+V SLIS VGIFC+GSG +  +GV  +    P 
Sbjct: 157 QALLAYGLSSSRRAPDALHPYGYSKERFVWSLISAVGIFCLGSGATIVNGVQNLWTSSPP 216

Query: 208 HDFYWAYFVLGGAVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTA 267
            +   A  V+GG+ + EGA+L+VA+ +++KGA +  M++ +Y+ R  DP+   V+ ED A
Sbjct: 217 PNMELAAVVIGGSFLIEGASLLVAIQSVKKGAAQEGMTIRDYIWRGHDPTSVAVMTEDGA 276

Query: 268 AVAGVIVAASCMAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQL 327
           AVAG+ +AA+ +   + TGNP+ D +GSI+VG +LG VA F+I  N  AL+GR++  + +
Sbjct: 277 AVAGLAIAAASLVAVRMTGNPIYDPIGSIVVGNLLGMVAIFLIQRNRHALIGRAMDDQDM 336

Query: 328 DEINSVLERDFMIRAIHDVKGIDIGSNLIRYKAEVDFDGRALTRSYLE---KHDLNALLE 384
            ++   L  D ++ +++D K   IG    R+KAE+DF+G+ + ++YL+   + +   +  
Sbjct: 337 SKVLKFLRNDSVVDSLYDCKSEVIGPGSFRFKAEIDFNGQMVVQNYLKRTGREEWAKMFR 396

Query: 385 DMKKIDTIDDVETFLLKHGENIVDMLGGEIDRIELKLRKKFPQIRHCDLE 434
           +  K      +   +  +GE +V  LG E+DR+E ++++  P I+H D+E
Sbjct: 397 EAAKNGDDSAMLNIMSNYGEEVVTALGSEVDRLEKEIQELVPGIQHVDIE 446


>UniRef50_Q01GU4 Cluster: Membrane protein HUEL; n=2;
           Ostreococcus|Rep: Membrane protein HUEL - Ostreococcus
           tauri
          Length = 481

 Score =  238 bits (582), Expect = 2e-61
 Identities = 126/333 (37%), Positives = 195/333 (58%), Gaps = 1/333 (0%)

Query: 103 RSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMA 162
           R+ + V TAIG N    + K+ A+  +GS S+ +E IHS+AD VNQ++L  GI  S +  
Sbjct: 147 RALKAVHTAIGCNAAILVCKMGAYGVSGSPSMLAESIHSVADIVNQVLLQVGITNSNKKP 206

Query: 163 DPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVV 222
           D    YGY   R+V SLIS VGIF +G+G S  HGV G++DP P  + + A  VL  +  
Sbjct: 207 DAKFNYGYRRERFVYSLISAVGIFFLGAGFSVMHGVHGLMDPMPTENLWVAISVLSASAA 266

Query: 223 SEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAIS 282
            EG +L VA  A+R  AR  +M+L E++    DP+   V  EDTAAV G  +A + +   
Sbjct: 267 LEGYSLKVAYEALRDNARAQDMTLTEFIKSGKDPTSLAVFAEDTAAVLGCGIATTALLAC 326

Query: 283 QYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRA 342
             TGNP+ D++GSI VG +LG  A ++I SN   L+GRS+  +++D I + + RD ++  
Sbjct: 327 YATGNPMYDSMGSIAVGGLLGATALYLINSNRLLLLGRSLGEDKMDVITAHMRRDPVVEE 386

Query: 343 IHDVKGIDIGSNLIRYKAEVDFDGRALTRSYLEKHDLN-ALLEDMKKIDTIDDVETFLLK 401
           ++  K  ++G+   R+  EV+F G+ +   YL KH    AL       +    ++  L++
Sbjct: 387 VYFAKSEELGAGAYRFAVEVEFSGKKIVERYLAKHQRRMALHSKFSAANDPKALDAALVQ 446

Query: 402 HGENIVDMLGGEIDRIELKLRKKFPQIRHCDLE 434
           +GE+IV  +G E+DR+E ++ +  P I + D+E
Sbjct: 447 YGEDIVQAVGDEVDRLEKEIVEIEPSIHYVDIE 479


>UniRef50_Q4RTG8 Cluster: Chromosome 1 SCAF14998, whole genome
           shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
           Chromosome 1 SCAF14998, whole genome shotgun sequence -
           Tetraodon nigroviridis (Green puffer)
          Length = 419

 Score =  234 bits (572), Expect = 4e-60
 Identities = 122/284 (42%), Positives = 184/284 (64%), Gaps = 15/284 (5%)

Query: 168 YGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVL---GGAVVSE 224
           YG++NMRY++SLISGVGIF +G+GLS+YHG+ G+L PQP+    W        G  V+S 
Sbjct: 136 YGFSNMRYIASLISGVGIFMMGAGLSWYHGIMGLLHPQPMESLLWVSVSGKPGGPEVLSN 195

Query: 225 GATLMV------ALSAIRKGAREANMSLYEYVMR-----SSDPSVNVVLLEDTAAVAGVI 273
           GA  +V          +    RE +++   +++R         S +        A+  + 
Sbjct: 196 GADPLVLSYRPTVFWQVPWSQREVSLTNISFIIRIFHLFELKRSRSCFAATLLVAINEIK 255

Query: 274 VAASCMAISQYT-GNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINS 332
            +A    +S Y  GNP  D+LGS+ VGT+LG V++F+I +N  AL+GRSI  E++ ++  
Sbjct: 256 KSARQNGLSFYEYGNPYYDSLGSLGVGTLLGTVSAFLIYTNTEALLGRSIQAERVQKLTE 315

Query: 333 VLERDFMIRAIHDVKGIDIGSNLIRYKAEVDFDGRALTRSYLEKHDLNALLEDMKKIDTI 392
            LE D  +RAIHDVK  D+G + +R+KAEVDFDGR +TRSYLEK D++ +L +++++ T 
Sbjct: 316 FLENDPAVRAIHDVKATDMGLSKVRFKAEVDFDGRVVTRSYLEKQDIDQILSEIQQVKTP 375

Query: 393 DDVETFLLKHGENIVDMLGGEIDRIELKLRKKFPQIRHCDLEIL 436
           +++E F+LKHGENI+D LG E+DR+E  L+++ P++RH DLEIL
Sbjct: 376 EELENFMLKHGENIIDTLGAEVDRLEKGLKQRNPEVRHVDLEIL 419



 Score = 74.5 bits (175), Expect = 5e-12
 Identities = 39/116 (33%), Positives = 64/116 (55%), Gaps = 1/116 (0%)

Query: 1   MRAMTEYLLKQSDLESLPKVLRRSPYESEPPITVYYRRDVEAKAIEIWGSKXXXXXXXXX 60
           +RAM E+ LK SDLE L ++ RRSP++     TV+ R DVEAKAI++WGS+         
Sbjct: 23  VRAMNEFCLKPSDLEQLRRIRRRSPHDDTEAFTVFLRSDVEAKAIDVWGSQEALARERNL 82

Query: 61  XXXXXXXXXQDVFTVKRRLRDYRREMSHTRSKDNVEEVGLKTRSGRVVLTAIGING 116
                    +++F  ++ L++Y+    +T+ +       L+   G+VV+ AI + G
Sbjct: 83  RKEMEKEYQENIFRNQQLLKEYKHFWGNTKPRAGKRTTFLQ-GPGKVVMVAICMYG 137


>UniRef50_A6G134 Cluster: Predicted Co/Zn/Cd cation transporter;
           n=1; Plesiocystis pacifica SIR-1|Rep: Predicted Co/Zn/Cd
           cation transporter - Plesiocystis pacifica SIR-1
          Length = 331

 Score =  220 bits (537), Expect = 7e-56
 Identities = 125/335 (37%), Positives = 197/335 (58%), Gaps = 6/335 (1%)

Query: 100 LKTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSV 159
           + +  G V+   IG N    + K  A++ TGS ++FSE IHS AD  NQ +L  GI  S 
Sbjct: 1   MASSKGAVLGALIG-NSVLTVIKFTAFWLTGSGAMFSEAIHSAADAANQGLLFVGIRSSE 59

Query: 160 QMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGG 219
           + AD    YGY   RY+ SL+S VGIF  GSGL+ YHGV   L P+P+   + +Y VLG 
Sbjct: 60  RPADNAFHYGYGYDRYLFSLLSAVGIFVFGSGLTVYHGVHSALHPEPVESSWISYAVLGI 119

Query: 220 AVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCM 279
           +++ +G  L  A+ AI   A++ + SL+ Y+  +SDP+V  VLLED  A  GV+VAA  +
Sbjct: 120 SLLVDGVVLAGAVRAI--WAKKGSQSLFAYLRTTSDPTVAAVLLEDAVATLGVLVAAGAI 177

Query: 280 AISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFM 339
           A+++ TGN L DA+G+I +G +LG VA ++ + N   L+G +IP    + + + LE+   
Sbjct: 178 ALTEVTGNSLFDAIGAIAIGGMLGLVAIWLGVKNRELLLGPAIPKRIWEGVMAYLEQHPA 237

Query: 340 IRAIHDVKGIDIGSNLIRYKAEVDFDGRALTRSYLEKHDLNALLEDMKKIDTIDDVETFL 399
           +  +   K   +G+   R+ AE++FDGR L    +   D +   + + +   +   + F 
Sbjct: 238 VGKVRKPKSRVVGAGQFRFAAEIEFDGRYLGEKLVGVVDEHVANDALAE---VAGRKAFA 294

Query: 400 LKHGENIVDMLGGEIDRIELKLRKKFPQIRHCDLE 434
            + GE +V ++G E+D IE +LRK++P++ H D+E
Sbjct: 295 GEFGERLVTLVGDEVDEIERELRKRYPELVHVDIE 329


>UniRef50_A6C709 Cluster: Cation efflux protein; n=1; Planctomyces
           maris DSM 8797|Rep: Cation efflux protein - Planctomyces
           maris DSM 8797
          Length = 335

 Score =  200 bits (489), Expect = 4e-50
 Identities = 115/336 (34%), Positives = 190/336 (56%), Gaps = 7/336 (2%)

Query: 101 KTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQ 160
           ++ S   V+ A+  N    + K   +  TGS ++ SE IHS+AD +NQ++L  G+ ++ Q
Sbjct: 3   QSNSRFAVIAALIGNALITVAKGATFLITGSGAMLSETIHSVADFLNQVLLLIGLVRADQ 62

Query: 161 MADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPL--HDFYWAYFVLG 218
             D    YGY   RYV +LIS VGIF +G G++ YHGV  +  P  L   +  WA   L 
Sbjct: 63  APDKRFEYGYAGERYVWALISAVGIFFLGCGVTIYHGVQSLFHPPDLVLGEMNWAIAALL 122

Query: 219 GAVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASC 278
            A+V +G    +AL    K A       ++Y+ + +DP+   V+LED AA  GVI+A   
Sbjct: 123 FALVIDGIVFYLALKGEWKNAAREGRPFHQYLRKEADPAAVAVILEDGAACVGVIIALIS 182

Query: 279 MAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDF 338
           + ++Q TG    DA+GSI +G +LGG+A ++I+ N   LVG SIP    +++  +L+ + 
Sbjct: 183 ILLTQMTGQHYWDAIGSIGIGILLGGIAIWLIIRNQELLVGPSIPPRTREQVERILKNNP 242

Query: 339 MIRAIHDVKGIDIGSNLIRYKAEVDFDGRALTRSYLEKHDLNALLEDMKKIDTIDDVETF 398
           ++  + D++   +  +  R KA++ F+ + L++  L+K  L A  E    I +  D E F
Sbjct: 243 LVEDVLDLRSRILSIDNYRIKADLSFNSQELSKR-LKKKALAAYPE----IKSEQDFELF 297

Query: 399 LLKHGENIVDMLGGEIDRIELKLRKKFPQIRHCDLE 434
              + E+++ ML  EID+IE +++++ P+ +H DLE
Sbjct: 298 CQNYTEDVLTMLADEIDKIEAEIQRQVPEAQHLDLE 333


>UniRef50_A0M1Q8 Cluster: CDF family cation efflux protein; n=1;
           Gramella forsetii KT0803|Rep: CDF family cation efflux
           protein - Gramella forsetii (strain KT0803)
          Length = 305

 Score =  176 bits (428), Expect = 1e-42
 Identities = 100/291 (34%), Positives = 156/291 (53%), Gaps = 2/291 (0%)

Query: 104 SGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMAD 163
           S   +  AIG N    + K  A F+TGS ++ +E IHSL DT N L+L  GI +S Q  D
Sbjct: 6   SNIAIYGAIGANLLIAISKFLASFFTGSSAMLAEGIHSLVDTGNGLLLLLGIKRSKQKPD 65

Query: 164 PDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVS 223
             HP+GY    Y  S +  + IF +G G + Y G+  I DP  + D  W Y+VLG A+V 
Sbjct: 66  KMHPFGYGKEVYFWSFVVSILIFALGGGFAIYEGIHAIQDPHVIEDPTWNYWVLGAAIVF 125

Query: 224 EGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQ 283
           EG  L +AL    K  +  + +L + +++S D +   V++EDTAAV G+ VA   + +SQ
Sbjct: 126 EGTALYLALKTFNKSRKHKSKNLIKNIIKSKDAATFAVIIEDTAAVVGLTVALIGVFLSQ 185

Query: 284 YTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAI 343
             GNP  D   SI++GTIL  VA+F+   + G L+G S   E +++I++++     + A 
Sbjct: 186 VFGNPYLDGAASIVIGTILLAVATFLAKESKGLLLGESAHDEVIEDIDNLINSKAYVNAS 245

Query: 344 HDVKGIDIGSNLIRYKAEVDF-DGRALTRSYLEKHDL-NALLEDMKKIDTI 392
           +  + +  G + I    E+D  D      +     DL N ++++  KI  +
Sbjct: 246 NIPQTMHFGPDKILLIVEIDLVDNLEFLEAEKIVDDLRNEIMQEKPKIKEV 296


>UniRef50_Q1Q491 Cluster: Putative uncharacterized protein; n=1;
           Candidatus Kuenenia stuttgartiensis|Rep: Putative
           uncharacterized protein - Candidatus Kuenenia
           stuttgartiensis
          Length = 337

 Score =  163 bits (395), Expect = 1e-38
 Identities = 103/339 (30%), Positives = 176/339 (51%), Gaps = 12/339 (3%)

Query: 100 LKTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSV 159
           +K  S  VVL+AI  N    + K   W  + S S+ +E IHS ADT NQ++L  GI  S 
Sbjct: 7   VKDDSVVVVLSAICGNLLLTIAKFSGWLISRSPSMLAEAIHSFADTANQILLYVGIQHSR 66

Query: 160 QMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPL--HDFYW-AYFV 216
                + P+G  + RY+ +LIS VGIF VG G++ YHG++ +  P      + YW +  +
Sbjct: 67  SGPSREFPWGQGSSRYLWNLISAVGIFFVGFGVTTYHGISSLFKPHEAFRSELYWLSITI 126

Query: 217 LGGAVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAA 276
           L  +   EG  L +A   ++K  ++   SL   V+   D ++  VLLED+ AV GV+ A 
Sbjct: 127 LALSFFVEGYVLTIAYKKLKK--KQDRRSLRNIVLSGDDSTITAVLLEDSIAVLGVVTAL 184

Query: 277 SCMAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLER 336
           + + +S    + LPDA+ SI++G  LG +A  +   N   L+G ++  ++  +I   +  
Sbjct: 185 TGLWLSHIYQSHLPDAVASIIIGIFLGIMAVLLAFVNGRLLIGMAVSEKKEKDIRQFIGI 244

Query: 337 DFMIRAIHDVKGIDIGSNLIRYKAEVDFDGRALTRSYLEKHDLNALLEDMKKIDTIDDVE 396
              +  +  +K   +G N+++  AE++F G  +        D   +  D + I   ++  
Sbjct: 245 YPSVEKVISLKTQILGPNMVKLTAEIEFHGGIM-------FDRKQVEADAELIRQGEEPL 297

Query: 397 TFLLKHGENIVDMLGGEIDRIELKLRKKFPQIRHCDLEI 435
             L+   E  V ++G EI+++E  +R++FP+I    LE+
Sbjct: 298 PILVDTIERTVRVVGNEINKLERAIRERFPEISSISLEV 336


>UniRef50_Q2SF35 Cluster: Predicted Co/Zn/Cd cation transporters;
           n=2; Gammaproteobacteria|Rep: Predicted Co/Zn/Cd cation
           transporters - Hahella chejuensis (strain KCTC 2396)
          Length = 313

 Score =  156 bits (379), Expect = 9e-37
 Identities = 88/261 (33%), Positives = 142/261 (54%), Gaps = 2/261 (0%)

Query: 104 SGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMAD 163
           S +V+  A+  N    L K  A  +TGS ++FSE +HS+ DT NQ++L +G+ +S + A 
Sbjct: 5   SKKVIYAALVGNALVALTKFAAAAFTGSSAMFSEGVHSVVDTGNQVLLLHGMKRSQRPAS 64

Query: 164 PDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVS 223
            D P+G+    Y  S I  + IF +G+G+S Y GV  IL PQ + +    Y VL  A++ 
Sbjct: 65  EDFPFGHGKEIYFWSFIVAILIFALGAGISIYEGVEHILHPQVVENPVVNYIVLSLAIIF 124

Query: 224 EGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQ 283
           EG    +A+   R    +  M  +E V R  DPS+ VVL ED AA+ G++VA   + + Q
Sbjct: 125 EGFAFGMAVKEFRNA--KGRMGYFEAVQRGKDPSLFVVLFEDAAAMLGLLVALGGIIMGQ 182

Query: 284 YTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAI 343
            TGNP+ D + S+++G ILG  A ++ +   G L+G S   + +  I  +      +  +
Sbjct: 183 VTGNPVYDGVASVIIGCILGLTALWLAVETKGLLIGESASKKVVKAIREMTCAIPGVEHV 242

Query: 344 HDVKGIDIGSNLIRYKAEVDF 364
           ++V  + +G + +     VDF
Sbjct: 243 NEVLTMHMGPDFVLVNLSVDF 263


>UniRef50_Q3JA92 Cluster: Cation efflux protein; n=4; Bacteria|Rep:
           Cation efflux protein - Nitrosococcus oceani (strain
           ATCC 19707 / NCIMB 11848)
          Length = 321

 Score =  156 bits (378), Expect = 1e-36
 Identities = 90/263 (34%), Positives = 142/263 (53%), Gaps = 3/263 (1%)

Query: 104 SGR--VVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQM 161
           SGR  V+  AI  N    + K  A +++GS ++ SE IHS+ DT N+L+L  G+ +S + 
Sbjct: 6   SGRLLVIYGAIAANFFIAVAKFIAAYFSGSSAMLSEGIHSMVDTGNELLLLLGVKRSNKP 65

Query: 162 ADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAV 221
           AD  HP+GY    Y  SLI  + +F +GSG+S Y G+T +L P  + D  W+Y VLG A 
Sbjct: 66  ADEQHPFGYGKELYFWSLIVAIALFGIGSGMSIYEGITHLLHPTEITDPTWSYIVLGIAF 125

Query: 222 VSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAI 281
           V+EG + ++AL  +   ++  + S ++ +  S DPSV  V  ED+AA+AGV+VA   + +
Sbjct: 126 VAEGISWIIALKEL-LASKNRDRSFWQALRISKDPSVFTVFCEDSAALAGVVVAFLGVYL 184

Query: 282 SQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIR 341
                N   D   SI++G IL  VA F+I      LVG S   + +  I+ +   D  + 
Sbjct: 185 GHTLNNHYFDGSASIVIGLILAAVALFLIYEGKHLLVGESADPQIVRHIHEIANTDPAVA 244

Query: 342 AIHDVKGIDIGSNLIRYKAEVDF 364
            +     +  G + +    ++ F
Sbjct: 245 DLRRPLTMHFGPDQVLLNLDIKF 267


>UniRef50_Q1QCT7 Cluster: Cation diffusion facilitator family
           transporter; n=2; Proteobacteria|Rep: Cation diffusion
           facilitator family transporter - Psychrobacter
           cryohalolentis (strain K5)
          Length = 365

 Score =  156 bits (378), Expect = 1e-36
 Identities = 103/276 (37%), Positives = 141/276 (51%)

Query: 91  SKDNVEEVGLKTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLI 150
           SK        K+ S   VL A+G N    + K  A F TGS S+ +E  HS AD  N  +
Sbjct: 43  SKSTPSHDDKKSSSLTTVLIAVGANLIIAIAKTVAAFMTGSASMIAESAHSWADAGNGTL 102

Query: 151 LAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDF 210
           L     KSV+ AD  HP GY    YV S+I+  G+F  GS +S Y G+T     +   ++
Sbjct: 103 LIVAEKKSVKPADKSHPLGYGKESYVWSMIAAFGVFMAGSVVSIYTGITEWNAAETETNY 162

Query: 211 YWAYFVLGGAVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVA 270
              + +L  A V EG +L  A    +K     N+S   YVM +S+P++  V  ED AAV 
Sbjct: 163 TIGFIILAVAFVLEGFSLTQAYLQSKKHGEAINVSAIGYVMDTSNPTLRGVFFEDLAAVI 222

Query: 271 GVIVAASCMAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEI 330
           G++VAA+ MA+  YTG P  DALGSI+VG +L  VA F+I  N   LVG  +  +  D I
Sbjct: 223 GLVVAAAAMAMHAYTGEPFWDALGSIIVGILLAVVAVFLISRNRDFLVGYRVSEKMHDYI 282

Query: 331 NSVLERDFMIRAIHDVKGIDIGSNLIRYKAEVDFDG 366
            S L +   I ++  +    +G   I   A VD  G
Sbjct: 283 LSELIKHPDIDSVSYLHLEWVGPKKIFMVAAVDIAG 318


>UniRef50_Q0F0R3 Cluster: Predicted Co/Zn/Cd cation transporters;
           n=1; Mariprofundus ferrooxydans PV-1|Rep: Predicted
           Co/Zn/Cd cation transporters - Mariprofundus
           ferrooxydans PV-1
          Length = 323

 Score =  150 bits (363), Expect = 8e-35
 Identities = 92/293 (31%), Positives = 157/293 (53%), Gaps = 10/293 (3%)

Query: 104 SGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMAD 163
           S R VLTA+  N    + K   +F +GS +L +E +HSLADT NQ +L  G+ +S + AD
Sbjct: 5   STRTVLTALAGNSLVTMAKFFGFFVSGSSALLAEAVHSLADTANQGLLYLGLRRSTRKAD 64

Query: 164 PDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVS 223
            +H +GY   RY  +L+S V IF +G G +  H V  + D       +  + ++G + ++
Sbjct: 65  SEHHFGYGQERYFWNLVSAVTIFFLGCGYTIMHAVEQLHDAHQPELSWIPFLIIGVSFLA 124

Query: 224 EGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQ 283
           EG +L VAL+  R+ A  A   L  Y + + DP+   VL+ED+ AV G++VA   M ++ 
Sbjct: 125 EGYSLGVALTEFRQQAGAAGKPLRTYFVETRDPTTLAVLIEDSVAVLGLMVALIGMGLAA 184

Query: 284 YTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLER----DFM 339
           +TG+ + D + +I +G ++G +A F+   N   L+ RS      DE+N++  R    D  
Sbjct: 185 WTGSAMFDGVAAICIGLMMGVLALFLASINRKYLLNRSD-----DEVNNIAARVWQADRQ 239

Query: 340 IRAIHDVKGIDIGSNLIRYKAEVDFDGRALTRSYLEKHDLNALLEDMKKIDTI 392
           ++ +  V  I +  +     AEV+    A+    +   +++  +  M+K+D I
Sbjct: 240 VQHVQRVNSIVLSPDDTLLMAEVELREEAIFAD-MSADEVSRAIRFMRKLDMI 291


>UniRef50_Q98D48 Cluster: Mll4860 protein; n=10; Proteobacteria|Rep:
           Mll4860 protein - Rhizobium loti (Mesorhizobium loti)
          Length = 317

 Score =  146 bits (354), Expect = 1e-33
 Identities = 84/262 (32%), Positives = 141/262 (53%), Gaps = 2/262 (0%)

Query: 104 SGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMAD 163
           S  V+  A+  N    L K  A F+TGS ++ SE +HSL DT N  +L YG+H++ + AD
Sbjct: 7   SKTVIYAALAGNLAIALTKFAAAFFTGSSAMLSEGVHSLVDTGNGGLLLYGMHRAARPAD 66

Query: 164 PDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVS 223
             HP G+    Y  S I  + +F +G+G+S Y G+  I+ P+P+ +    Y VLG + + 
Sbjct: 67  RTHPLGHGRELYFWSFIVALLVFALGAGVSLYEGIIHIIAPEPVANVKVNYIVLGLSFLF 126

Query: 224 EGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQ 283
           EG++ +VAL   R+   +   S  + +  S DPSV  VL ED+AA+ G+IVA + +  ++
Sbjct: 127 EGSSWLVALKEFRR--EKGRQSWLQALQSSKDPSVYTVLFEDSAALLGLIVAFAGILAAE 184

Query: 284 YTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAI 343
               P  D   SI +  ILG  A F+   + G L+G     E   ++ +++++D  ++  
Sbjct: 185 LLEMPELDGAASIGIAFILGATAIFLARESKGLLIGEPASPEVQKKVLAIVQQDSAVQRA 244

Query: 344 HDVKGIDIGSNLIRYKAEVDFD 365
           + V  + +G   I     ++F+
Sbjct: 245 NGVLTVHMGPREIVAGLSIEFE 266


>UniRef50_A6EC28 Cluster: Predicted Co/Zn/Cd cation transporter;
           n=1; Pedobacter sp. BAL39|Rep: Predicted Co/Zn/Cd cation
           transporter - Pedobacter sp. BAL39
          Length = 318

 Score =  145 bits (351), Expect = 2e-33
 Identities = 76/232 (32%), Positives = 130/232 (56%), Gaps = 2/232 (0%)

Query: 103 RSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMA 162
           R+ + + +A+  N    + K  A  ++ S S+ SE IHSL DT+NQ++L YG+ +S + A
Sbjct: 21  RNNKSIYSALAANLLIAITKFIAGAFSNSSSMISEGIHSLVDTINQVLLLYGLKRSRRPA 80

Query: 163 DPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVV 222
           D   P+GY    Y  S I  + IF +G G+S Y G+  I++P+PL D  W Y V+G +++
Sbjct: 81  DAGRPFGYGKELYFWSFIVAIMIFGLGGGISIYQGIDHIIEPEPLGDPTWNYVVIGLSIL 140

Query: 223 SEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAIS 282
            E ++L +A+      A    +  ++ +++S DPS  +VL ED+AAV G+++    M I 
Sbjct: 141 FESSSLYIAIKEF--NALRNGLGWWKAIVKSKDPSSFLVLFEDSAAVMGLLIVLVFMIIG 198

Query: 283 QYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVL 334
            +   P  D + S+ VG +L  V++ +   +   L+G  I  E   +I S++
Sbjct: 199 HHYQLPFMDGVASVCVGLLLVLVSAILARESRSLLMGEGIAPETQQKITSII 250


>UniRef50_A3IUW6 Cluster: Predicted Co/Zn/Cd cation transporters;
           n=3; Bacteria|Rep: Predicted Co/Zn/Cd cation
           transporters - Cyanothece sp. CCY 0110
          Length = 303

 Score =  144 bits (348), Expect = 5e-33
 Identities = 80/261 (30%), Positives = 137/261 (52%)

Query: 104 SGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMAD 163
           S R +  A+  N    + K      +GS ++ SE IHS+ D++N+++L YG+ +S +  D
Sbjct: 5   STRTIYAAMIANIAIGVAKFFGAAISGSSAMLSEGIHSVVDSINEVLLLYGLKRSKKEPD 64

Query: 164 PDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVS 223
            DHP G+    Y  SL+  V IF +G G+S Y G     D +   +   +Y VL  A V 
Sbjct: 65  EDHPLGHGQEIYFWSLVVAVLIFALGGGISIYEGFKSFHDSRESTNAIVSYGVLSIAAVF 124

Query: 224 EGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQ 283
           EG  L +++    +   + N++ ++ + RS +P+  VV+ EDTAA+ G++VA   + +S+
Sbjct: 125 EGTALFISVQEFNQERSDNNINFWKALRRSKNPTTFVVIFEDTAALLGIVVAILGVFLSE 184

Query: 284 YTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAI 343
            TG    D L SI++G IL  VA  +++   G L+G S   E  D I +++ +D  +  +
Sbjct: 185 LTGTIFYDGLASIIIGVILTIVAIVLVIETKGLLIGESAFPEVRDSIKNIVVKDTSVYKV 244

Query: 344 HDVKGIDIGSNLIRYKAEVDF 364
                + +G   I     ++F
Sbjct: 245 ESPITLQLGPTDILLALSIEF 265


>UniRef50_A1SQA1 Cluster: Cation diffusion facilitator family
           transporter precursor; n=3; Actinomycetales|Rep: Cation
           diffusion facilitator family transporter precursor -
           Nocardioides sp. (strain BAA-499 / JS614)
          Length = 298

 Score =  144 bits (348), Expect = 5e-33
 Identities = 85/256 (33%), Positives = 132/256 (51%)

Query: 111 AIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGY 170
           A+  NG   + K  A   TGS S+ +E  HS ADT N++ L     K  +  D +HP GY
Sbjct: 2   ALVANGLLAIAKSVAAAVTGSASMVAEAAHSWADTGNEVFLLVAERKGSRPRDEEHPRGY 61

Query: 171 TNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMV 230
               Y+ SL++  G+F  G+ +S +HG+T +   +    +   Y VLG A V EG +   
Sbjct: 62  GRSTYIWSLVAAFGLFSAGAVVSLWHGITELTGEEAAPSYAVNYIVLGVAFVLEGVSFAQ 121

Query: 231 ALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLP 290
           A   +   AR   +    +V R+S+P++  V  ED+AA+AG+++A + +A+ Q TG  + 
Sbjct: 122 ATRQVHGAARRFGLHPLRFVSRTSNPTLRAVFFEDSAALAGILLAGAGIALHQVTGEAVF 181

Query: 291 DALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDVKGID 350
           DALGSI VG +LG VA F++  N+  L+G  +  E    + + L     I  I  +    
Sbjct: 182 DALGSIAVGILLGFVAVFLMRRNMDYLLGEGLTPELRSRVIAQLLEHPQIDRITYLHVEY 241

Query: 351 IGSNLIRYKAEVDFDG 366
           +G   +   A VD  G
Sbjct: 242 VGPQRLFVVAAVDLTG 257


>UniRef50_Q0BR38 Cluster: Cobalt-zinc-cadmium resistance protein
           czcD; n=2; Proteobacteria|Rep: Cobalt-zinc-cadmium
           resistance protein czcD - Granulobacter bethesdensis
           (strain ATCC BAA-1260 / CGDNIH1)
          Length = 341

 Score =  142 bits (343), Expect = 2e-32
 Identities = 79/261 (30%), Positives = 139/261 (53%), Gaps = 2/261 (0%)

Query: 107 VVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDH 166
           VV  A+G N    + K  A   TGS ++ SE +HSL DT NQL++ +G+  + + A P+H
Sbjct: 36  VVFAALGGNFAIAVMKFAAAASTGSSAMLSEAVHSLVDTGNQLLMLWGMRCAARPATPEH 95

Query: 167 PYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGA 226
           P+G+    Y  S +  V IF +G+G+S + GV  +  P  +   +  Y VLGG+ V EG 
Sbjct: 96  PFGHGLELYFWSFMVAVLIFGLGAGVSIFEGVEKLRHPVSVTHVWPNYLVLGGSFVFEGI 155

Query: 227 TLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTG 286
             ++A+ A  +  ++  + + E    S DP+V  VL EDTAA+ G++ A   + ++Q+  
Sbjct: 156 VWLLAMRAFLR--QKGRLGVLEAAQASKDPTVFTVLFEDTAALLGLLTAGVGLGLAQWLH 213

Query: 287 NPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDV 346
            P  DA+ S+++G IL   A F+   +   L+G S P    + I  ++  +  +   +++
Sbjct: 214 QPAFDAIASLVIGGILAVTALFLARESRSLLIGESAPLAVREHIRRIVASEPGVVCANEI 273

Query: 347 KGIDIGSNLIRYKAEVDFDGR 367
             +  G + +     +DF+ +
Sbjct: 274 LTMHFGPSEVLVAISMDFENQ 294


>UniRef50_Q9L081 Cluster: Putative membrane transport protein; n=1;
           Streptomyces coelicolor|Rep: Putative membrane transport
           protein - Streptomyces coelicolor
          Length = 326

 Score =  141 bits (341), Expect = 4e-32
 Identities = 84/243 (34%), Positives = 132/243 (54%)

Query: 122 KLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLIS 181
           K  A   +GS ++ SE  HS+ADTV +++L   + +SV+ AD DHP G+   RY+ +L++
Sbjct: 34  KAVAGVISGSSAMLSEAAHSVADTVTEVLLLTSLKRSVRPADEDHPLGHGPERYIWALLA 93

Query: 182 GVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGARE 241
            V  F  G+  S Y G+  +   + L D   +Y VL  A V EG +L   L  +R  A  
Sbjct: 94  AVATFVGGAVFSLYDGIHTLTHGEDLGDPLVSYIVLAVAFVLEGYSLRTGLRQVRGEAAH 153

Query: 242 ANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGTI 301
             +S   Y+ R+ D +V  V++ED+AA+AG+++AA  +   Q TG+ + DA+ S+ +G +
Sbjct: 154 HRVSFGRYLRRTPDTAVKAVVMEDSAALAGLLLAAGGLLGGQLTGSGVWDAVASLCIGAL 213

Query: 302 LGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDVKGIDIGSNLIRYKAE 361
           L  VA  +  SN   LVGR +     D I + L  D  I A+ ++  +  G       A+
Sbjct: 214 LLYVAWVLGRSNAEFLVGRPLSRSVRDRIRAELVADEHIEAVLELTTLVQGPREALVAAK 273

Query: 362 VDF 364
           VDF
Sbjct: 274 VDF 276


>UniRef50_A5V609 Cluster: Cation diffusion facilitator family
           transporter precursor; n=2; Sphingomonas|Rep: Cation
           diffusion facilitator family transporter precursor -
           Sphingomonas wittichii RW1
          Length = 308

 Score =  140 bits (339), Expect = 7e-32
 Identities = 82/259 (31%), Positives = 135/259 (52%), Gaps = 2/259 (0%)

Query: 107 VVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDH 166
           ++  A+  N    + K  A   TGS ++ +E  HS+ D++NQL+L YG  +SV+  D  H
Sbjct: 10  ILFAALAANLGIAVAKFVAAAITGSSAMLTEGFHSVVDSLNQLLLLYGQKRSVRPPDERH 69

Query: 167 PYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGA 226
           P GY    Y  S +  + IF  G+GLS Y GV  +LDP+P+   +  Y VL  +++ EGA
Sbjct: 70  PLGYGRELYFWSFVVAILIFSTGAGLSIYEGVLHVLDPEPIRTPWVNYVVLALSLLLEGA 129

Query: 227 TLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTG 286
           +  +A+     GA +     +E V +S DP   +VL ED+AA+ G+ VA + + +S  TG
Sbjct: 130 SWGIAVREF--GAAKGEHGWWEAVRQSKDPPSFIVLFEDSAAMFGLFVAGAGITLSLLTG 187

Query: 287 NPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDV 346
           +   D + SI++G  L GVA  +       L+G          + + ++R   +  ++++
Sbjct: 188 DARWDGVASIVIGLALAGVALALAREAKDLLIGEPADPALEAAVRAAIDRRPEVTGVNEI 247

Query: 347 KGIDIGSNLIRYKAEVDFD 365
             + IG   I     VDF+
Sbjct: 248 TTVHIGPQAIFLGLAVDFE 266


>UniRef50_Q6A747 Cluster: Cation transport protein; n=1;
           Propionibacterium acnes|Rep: Cation transport protein -
           Propionibacterium acnes
          Length = 343

 Score =  134 bits (323), Expect = 6e-30
 Identities = 91/289 (31%), Positives = 144/289 (49%), Gaps = 12/289 (4%)

Query: 87  SHTRSKDN-VEEVGLKTRSGR-VVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLAD 144
           +H   + N  +E    T+ GR  ++ A   N    + K  AW  TG+ S+ +E IHS+AD
Sbjct: 4   AHAAQRPNGAKEPANPTQGGRKAIIAAASANLAIAVTKAIAWALTGASSMLAEAIHSVAD 63

Query: 145 TVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSF---YHGVTGI 201
           T NQ++L  G  +S + AD DHP+GY   RY+S  I  + IF +G   +    YH +   
Sbjct: 64  TANQVVLMMGGKESHKEADEDHPFGYETARYLSGFIVAIVIFTLGGLFALYEAYHKIGAT 123

Query: 202 L--DPQPLHDFYWAYFVLGGAVVS---EGATLMVALSAIRKGAREANMSLYEYVMRSSDP 256
           L   P  L D  W +  L   ++S   EGA+L  AL    +  RE  M++ +Y+ ++  P
Sbjct: 124 LGGHPDELLDSQWWWVPLAVVMISLCAEGASLRTALKESSQD-RE-GMTILQYIRKAKAP 181

Query: 257 SVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGA 316
            + VV+LED+AAV G+I A   + ++  T NP+ D +GS  +G +L  VA  +       
Sbjct: 182 ELPVVMLEDSAAVLGLIFAFLGVGLTLLTHNPIFDGIGSACIGILLVVVAGVLSREMKSL 241

Query: 317 LVGRSIPHEQLDEINSVLERDFMIRAIHDVKGIDIGSNLIRYKAEVDFD 365
           L G S   E    +   L     + ++  +K + +G   I   A++  D
Sbjct: 242 LEGESAAPESRKAVYDALIHSDGVDSVIYMKTVHLGPETILLAAKIAVD 290


>UniRef50_A6W6F7 Cluster: Cation diffusion facilitator family
           transporter; n=1; Kineococcus radiotolerans
           SRS30216|Rep: Cation diffusion facilitator family
           transporter - Kineococcus radiotolerans SRS30216
          Length = 353

 Score =  133 bits (321), Expect = 1e-29
 Identities = 86/280 (30%), Positives = 140/280 (50%), Gaps = 2/280 (0%)

Query: 86  MSHTRSKDNVEEVGLKT-RSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLAD 144
           MS T S  N    G     S   VL A+G N    + K  A   TGS ++ +E  HS+AD
Sbjct: 1   MSSTVSPTNHRSPGTGGGESTATVLVALGANALIAVAKGVAAVVTGSAAMAAETAHSVAD 60

Query: 145 TVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGIL-D 203
           TVN++ L   +  S + AD +HP GY   RY  +L++   IF  G+  S Y GV  +  +
Sbjct: 61  TVNEVFLLTALRTSARPADREHPLGYGRARYFWALVAAGSIFVTGALYSAYEGVEALTSE 120

Query: 204 PQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLL 263
              L     +Y VL  A V EG++L+  L   R  ARE      E++  + DP+   V+ 
Sbjct: 121 SHDLESPLVSYVVLAVAFVLEGSSLLKGLKQTRGEAREKRQGFREFLRTTDDPTATTVVF 180

Query: 264 EDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIP 323
           ED+AA+AG+++A +  A+ Q TG+ + D + S+ +  +L  VA  +  +N+  L G    
Sbjct: 181 EDSAALAGLLLAGAGTAMHQVTGSGVYDGIASLCIALLLALVAVRLARTNMRLLTGVQAD 240

Query: 324 HEQLDEINSVLERDFMIRAIHDVKGIDIGSNLIRYKAEVD 363
              +  +   L  +  + A+ D+  + +G++ +   A +D
Sbjct: 241 PRLVSSVLVHLGDEPEVEAVVDLLTVQLGTDQVLVCARLD 280


>UniRef50_Q6AHA9 Cluster: Cation transporter; n=1; Leifsonia xyli
           subsp. xyli|Rep: Cation transporter - Leifsonia xyli
           subsp. xyli
          Length = 320

 Score =  132 bits (319), Expect = 2e-29
 Identities = 84/264 (31%), Positives = 139/264 (52%), Gaps = 4/264 (1%)

Query: 106 RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD 165
           R ++ A   N    L KL AW ++GS S+ +E +HS+AD  NQL+L  G  ++ + AD  
Sbjct: 8   RAIVAAFAANLGIALTKLIAWLFSGSSSMLAEGVHSIADCGNQLLLLLGGRRAKKKADRK 67

Query: 166 HPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEG 225
           HP+GY   RYV + +  + +F  G   S Y GV  +     L + +    VL  A+  E 
Sbjct: 68  HPFGYGRERYVYAFVVSIVLFSAGGVFSLYEGVEKLTHRHSLENSWLPLLVLLIAIGLES 127

Query: 226 ATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYT 285
            +L  A+   R    + ++S  +++ R+  P + VVLLED AA+AG++ A   +++S  T
Sbjct: 128 FSLRRAIHESR--PHKQSISWLQFIRRAKAPELPVVLLEDVAALAGLLFALIGISLSVLT 185

Query: 286 GNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEI-NSVLERDFMIRAIH 344
           G+ + DA+G++L+GT+L  VA  +       LVG          I  +VL    + R IH
Sbjct: 186 GDAVWDAIGTLLIGTLLIVVALVLGFETKSLLVGEGASDSDAAAIERAVLSGGEVERIIH 245

Query: 345 DVKGIDIGSNLIRYKAEVDFDGRA 368
            +K + +G + + + A+V   G +
Sbjct: 246 -MKTLYLGPDELLFGAKVAMSGES 268


>UniRef50_A0GH18 Cluster: Cation diffusion facilitator family
           transporter; n=4; Burkholderiales|Rep: Cation diffusion
           facilitator family transporter - Burkholderia
           phytofirmans PsJN
          Length = 327

 Score =  129 bits (311), Expect = 2e-28
 Identities = 91/273 (33%), Positives = 144/273 (52%), Gaps = 5/273 (1%)

Query: 100 LKTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSV 159
           +K  S + +  A+  N    + K  A  +TGS S+F+E IHS AD  NQL+L +G+ ++ 
Sbjct: 27  MKEESPKAIFYALAANLGIAICKFAAAAFTGSGSMFAEAIHSTADCGNQLLLLFGLREAR 86

Query: 160 QMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGG 219
           + A P HP G        SL+  + +F VG   S Y GV  +   +PL   Y A  VLG 
Sbjct: 87  KPASPLHPMGGGREINFYSLLVALLLFFVGGAFSVYEGVHRLFVREPLQYAYVALAVLGV 146

Query: 220 AVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCM 279
           +VV E  +L  A+  IRK     + S++ +   + +  + VV  ED AA+AG+ +A + +
Sbjct: 147 SVVLEALSLWGAVKEIRK--THPDKSMWRWFRETRESELLVVAGEDIAALAGLAMAFAAV 204

Query: 280 AISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFM 339
            ++  TGNP+ DALGSI VG +L  +A  +       +VG S   E    I + L     
Sbjct: 205 LLTMMTGNPVYDALGSIGVGVLLMVIAWLVAREVKSMIVGESASPEVRRAIEAHLRGRTE 264

Query: 340 IRAIHDVKGIDIGSN-LIRYKAE-VDF-DGRAL 369
           IR+I ++  +  G + ++  +AE +D+  GRA+
Sbjct: 265 IRSIINMITLQWGRHVVVAVQAEMIDYASGRAM 297


>UniRef50_A5P265 Cluster: Cation diffusion facilitator family
           transporter; n=1; Methylobacterium sp. 4-46|Rep: Cation
           diffusion facilitator family transporter -
           Methylobacterium sp. 4-46
          Length = 316

 Score =  124 bits (300), Expect = 3e-27
 Identities = 73/259 (28%), Positives = 121/259 (46%), Gaps = 2/259 (0%)

Query: 107 VVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDH 166
           VV  A+  N      K  A  YTGS ++ +E +HS  DT NQ +L YG+ ++ + AD  H
Sbjct: 9   VVYAALAGNLAIAATKFAAALYTGSSAMVTEAVHSFVDTGNQGLLLYGMRRAARPADDSH 68

Query: 167 PYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGA 226
            +G+    Y  S +  + IF  G   + Y G+  I  P+P+   +    V+  A   EG 
Sbjct: 69  NFGHGLELYFWSFVVALMIFSAGGAFAIYEGIEKIRHPEPIDSAWVNVAVIAAAAFFEGL 128

Query: 227 TLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTG 286
           +   A   +R+  R A + L+  V RS DPS   V+LED AA+ G+  A +      + G
Sbjct: 129 SFRTAWREMRQ--RFARLPLWRAVARSKDPSTFAVVLEDGAALIGLAFALAGSVAVSWLG 186

Query: 287 NPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDV 346
            P  D + S+ +G +L   A  +       L G S     +++  ++L  D  +  +  V
Sbjct: 187 WPPGDGVASVAIGLLLIATAFVLFRETRSLLTGESASPRLIEQATAILRADPRVIGVSRV 246

Query: 347 KGIDIGSNLIRYKAEVDFD 365
           + + +G+  +     +D D
Sbjct: 247 RSLHLGTTTVLLAVSLDLD 265


>UniRef50_A7D914 Cluster: Cation diffusion facilitator family
           transporter; n=2; Methylobacterium extorquens PA1|Rep:
           Cation diffusion facilitator family transporter -
           Methylobacterium extorquens PA1
          Length = 340

 Score =  122 bits (293), Expect = 2e-26
 Identities = 76/267 (28%), Positives = 130/267 (48%), Gaps = 12/267 (4%)

Query: 108 VLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHP 167
           + TA G N      K    F TGS ++ +E  HSL DT NQL+L  G+ ++ + AD  HP
Sbjct: 8   IYTAAGANLAIAAAKFVGAFLTGSTAMLAEGAHSLVDTANQLLLLVGLKRAKKPADAKHP 67

Query: 168 YGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQP----------LHDFYWAYFVL 217
           +GY    Y  + I  + IF  G   + Y G   I  P+P          L  F+    +L
Sbjct: 68  FGYGREVYFYAFIVALFIFLGGGIFAIYEGAHKIEHPEPSADATLFGVQLSGFWVNVSIL 127

Query: 218 GGAVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAAS 277
           G A+++EG +  VA+ A    A +   S    + RS DP++  +L+ED AA+ G+++A  
Sbjct: 128 GFAILAEGYSCFVAVKAF--WAEKGQRSAITAIQRSKDPALYTILVEDVAALIGLVIAIG 185

Query: 278 CMAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERD 337
            + ++     P  D   SI +G +L G++ F+++   G L+G +     +  I + +  +
Sbjct: 186 GVVLAHVLDKPALDGWASIGIGLVLIGMSIFLMIETHGLLIGEAADPAVVRTIQAAVSEE 245

Query: 338 FMIRAIHDVKGIDIGSNLIRYKAEVDF 364
             ++ ++ V    +G + I     +DF
Sbjct: 246 SAVQHVNAVLTQHLGPSDILVNLSLDF 272


>UniRef50_A2XRM0 Cluster: Putative uncharacterized protein; n=1;
           Oryza sativa (indica cultivar-group)|Rep: Putative
           uncharacterized protein - Oryza sativa subsp. indica
           (Rice)
          Length = 298

 Score =  120 bits (288), Expect = 1e-25
 Identities = 58/145 (40%), Positives = 91/145 (62%)

Query: 203 DPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVL 262
           D  P  + ++A  V+GG+ + EGA+L+VA+ A+RKGA    MS+ +Y+ R  DP+   V+
Sbjct: 91  DANPPENIHYAALVIGGSFLIEGASLLVAIKAVRKGAAAEGMSIRDYIWRGHDPTSVAVM 150

Query: 263 LEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSI 322
            ED AAV G+ +A + +   Q TGN + D +GSI+VG +LG VA F+I  N  AL+GR+I
Sbjct: 151 TEDGAAVTGLAIAGASLVAVQTTGNAMYDPIGSIIVGNLLGMVAIFLIQRNRHALIGRAI 210

Query: 323 PHEQLDEINSVLERDFMIRAIHDVK 347
               +  +   L+ D ++ A++D K
Sbjct: 211 DDHDMQRVLEFLKADPVVDALYDCK 235



 Score = 41.1 bits (92), Expect = 0.056
 Identities = 18/44 (40%), Positives = 30/44 (68%), Gaps = 2/44 (4%)

Query: 393 DDVETF--LLKHGENIVDMLGGEIDRIELKLRKKFPQIRHCDLE 434
           DD E    +  +GE++V+ LG E+DR+E +++K  P I+H D+E
Sbjct: 246 DDTELIRVMSNYGEDVVEALGYEVDRLESEIQKIVPGIKHVDIE 289



 Score = 40.3 bits (90), Expect = 0.097
 Identities = 19/47 (40%), Positives = 26/47 (55%)

Query: 104 SGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLI 150
           S R V TA+  N   F  K   W  T SH + +E +HS+AD  NQ++
Sbjct: 30  SHRAVNTALWCNFLVFSLKFGVWLSTSSHVMLAELVHSVADFANQVL 76


>UniRef50_Q2JCE5 Cluster: Cation diffusion facilitator family
           transporter; n=14; Actinobacteria (class)|Rep: Cation
           diffusion facilitator family transporter - Frankia sp.
           (strain CcI3)
          Length = 341

 Score =  118 bits (283), Expect = 4e-25
 Identities = 75/264 (28%), Positives = 131/264 (49%), Gaps = 3/264 (1%)

Query: 100 LKTRSG-RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKS 158
           + T+ G + V+ A+  N    L K  A+  T S S+ +E IHS+AD+ NQ +L  G  +S
Sbjct: 1   MSTQGGTKAVMAALAANLGIALAKFVAFLVTQSSSMLAESIHSVADSGNQGLLLLGQKRS 60

Query: 159 VQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLG 218
           VQ  D +HP+GY   RY++  + G+ +F +G   S Y GV  +  P  L     A  VL 
Sbjct: 61  VQPPDEEHPFGYGRARYIAGFLVGIVLFSLGGLFSVYEGVEKLRHPHELESGLVAVVVLL 120

Query: 219 GAVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASC 278
            AV+ E  +   A+   +K   + + S + ++  +  P + +VLLED AA  G+I A   
Sbjct: 121 IAVLLESYSFATAMRESKK--TKGDRSWWRFIREARAPELPIVLLEDLAAELGLIFALLG 178

Query: 279 MAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDF 338
           + ++    +P+ D  G++ +G +L  VA  +     G LVG +     +  I   L    
Sbjct: 179 VGLTLALDDPIWDGAGTLAIGVLLLIVAVIVATEAYGMLVGEAAAPAMVATIRRTLAAAP 238

Query: 339 MIRAIHDVKGIDIGSNLIRYKAEV 362
            +  +  ++ + +G + +   A++
Sbjct: 239 GVATVIHLRTLHLGPDELLVAAKI 262


>UniRef50_Q825J3 Cluster: Putative transport protein; n=4;
           Streptomyces|Rep: Putative transport protein -
           Streptomyces avermitilis
          Length = 356

 Score =  117 bits (281), Expect = 7e-25
 Identities = 82/258 (31%), Positives = 130/258 (50%), Gaps = 9/258 (3%)

Query: 108 VLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHP 167
           VL A+G N    + K       GS +L SE  HS+AD++N++ L   + +S + AD  HP
Sbjct: 45  VLVALGANLVIAVAKAVGGLLAGSPALLSEAAHSVADSLNEVFLLAALRRSRRPADQRHP 104

Query: 168 YGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILD-PQPLHDFYWA-YFVLGGAVVSEG 225
           +GY   R+  SL++ VGIF +G   SF+ G+  +    +  H  Y A   VLG A+++EG
Sbjct: 105 FGYGKERFFWSLLAAVGIFVMGGCFSFFQGIEALRSGAEESHSGYVAGLIVLGVALLAEG 164

Query: 226 ATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYT 285
           A+L+ AL  +R     A   L        DP++  V+ ED  AV GV +A   MA+   T
Sbjct: 165 ASLLRALHQVRGQRGSAAEGL-------RDPALRTVVAEDGTAVLGVTLAMIGMALHMVT 217

Query: 286 GNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHD 345
           G  + +A  S+ +G +L  VA  +       L+G++   E    I ++LE    I ++  
Sbjct: 218 GQVVWEAAASMGIGALLVYVAYRLGRDARDQLIGQAADPELSGRIRALLEAQPEIDSVES 277

Query: 346 VKGIDIGSNLIRYKAEVD 363
           +  + +G +     A VD
Sbjct: 278 LLTMQLGLHSTLVAARVD 295


>UniRef50_A4J438 Cluster: Cation diffusion facilitator family
           transporter; n=1; Desulfotomaculum reducens MI-1|Rep:
           Cation diffusion facilitator family transporter -
           Desulfotomaculum reducens MI-1
          Length = 321

 Score =  116 bits (278), Expect = 2e-24
 Identities = 75/257 (29%), Positives = 129/257 (50%), Gaps = 7/257 (2%)

Query: 104 SGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMAD 163
           S   +  A+  NG   L KL     +GS S+ +E  HS+ D  N   L  GI +S +  D
Sbjct: 5   SESAIKAALLANGVIALMKLVGAILSGSASMMAEFKHSVGDWANGFFLLIGIRQSQRPID 64

Query: 164 PDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVS 223
             + +G+    +  S ++ +G+  +G  LS Y G+  I+ P+ L        ++  +++ 
Sbjct: 65  DRYQFGHGKRLFFWSFVASLGMLFIGGALSIYGGIQKIIHPEHLEYISLNLIIIVVSILF 124

Query: 224 EGATLMVALSAIRK--GAREANMSLYEYV---MRSSDPSVNVVLLEDTAAVAGVIVAASC 278
           E  ++ +A+ AI    G     M +Y  V   +  + P+   + LED+AA+ G+I+A   
Sbjct: 125 EIYSMTMAIKAIMHEVGEPARGMGMYFKVIPALTKATPATRFIFLEDSAALIGLIIAGLA 184

Query: 279 MAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEI-NSVLERD 337
           + +S  TGN L D + SI++G IL  +       NV A++G S   E + E+ N VL  D
Sbjct: 185 IILSVVTGNVLFDGMASIIIGVILLLIGLATAKENVAAILGESADPELVQEMGNYVLTLD 244

Query: 338 FMIRAIHDVKGIDIGSN 354
             ++ +H V+ + IG+N
Sbjct: 245 -GVKDVHSVRSMSIGAN 260


>UniRef50_Q3IUM9 Cluster: Transporter 37; n=1; Natronomonas
           pharaonis DSM 2160|Rep: Transporter 37 - Natronomonas
           pharaonis (strain DSM 2160 / ATCC 35678)
          Length = 308

 Score =  115 bits (276), Expect = 3e-24
 Identities = 76/266 (28%), Positives = 126/266 (47%), Gaps = 1/266 (0%)

Query: 107 VVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDH 166
           VV+ ++  +    + K  AW  TG+ S+ S+  +SL+D  NQL+   G   S   A   H
Sbjct: 7   VVVVSLVASAAIAVAKFIAWLATGNASMLSQVYYSLSDVGNQLLFLLGFRLSDAGASRKH 66

Query: 167 PYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGA 226
           P+G    +YV + +  + +F V    +   G   I  P    D    Y VLG A++ E A
Sbjct: 67  PFGRGKEQYVFAFVVTMLLFGVTGYAAVREGYETIGTPARDVDVTINYIVLGVALLFESA 126

Query: 227 TLMVALSAIRKGA-REANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYT 285
               +  A+R+ A  E   SL++   RS D  +     E+  AV GV+VA + + ++  T
Sbjct: 127 AFYKSYQAVREEADTEGFRSLFDTFRRSKDAPLLTAATENLVAVVGVLVALAGVYLTDVT 186

Query: 286 GNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHD 345
           GN   DA+GS ++G +L  VA  +   + G LVG  +   +   +   +     + A+ D
Sbjct: 187 GNTTYDAIGSAVIGLLLMSVALGLAWESRGLLVGEGVTRRERRRLLDAIAAADGVNAVVD 246

Query: 346 VKGIDIGSNLIRYKAEVDFDGRALTR 371
           ++ + +G   +    E+DFD    TR
Sbjct: 247 LRTMHLGPESVLVACEIDFDNDLDTR 272


>UniRef50_Q5UZ15 Cluster: Cation efflux protein; n=1; Haloarcula
           marismortui|Rep: Cation efflux protein - Haloarcula
           marismortui (Halobacterium marismortui)
          Length = 323

 Score =  112 bits (269), Expect = 2e-23
 Identities = 80/285 (28%), Positives = 132/285 (46%), Gaps = 23/285 (8%)

Query: 104 SGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMAD 163
           S  VV+ A+  NG   + K   +  TGS ++ SE  HS++DT NQ+ L  GI  S +  D
Sbjct: 4   SKSVVIAALIANGAIAILKFFGFLLTGSAAMLSETYHSISDTGNQVFLLIGIRFSERERD 63

Query: 164 PDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGI---------------------L 202
             HP+GY   ++  S +  V +F +    S  HG   +                      
Sbjct: 64  RRHPFGYGKAQFFYSFLVSVFLFGIAGWESAKHGYNQLTAGGHGGGGHAGEAVEFLFFSF 123

Query: 203 DPQPLHDFYWA-YFVLGGAVVSEGATLMVALSAIRKGAREANMSLYEYVMR-SSDPSVNV 260
            P    D  W  Y VL GA V E   L+ A + +++     N S Y    R +SD +   
Sbjct: 124 QPPAWLDPLWVNYTVLIGAFVFETYALIKARAEMKRQIDRNNWSGYREAFRKTSDVTTLT 183

Query: 261 VLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGR 320
            L EDT A+AG+++A   + + Q TGNP  D + ++L+G +L G A  +   N   L+G 
Sbjct: 184 ALTEDTIALAGIVIALVGLVLEQMTGNPFFDRVSALLIGIMLMGFALALAWENKRLLLGE 243

Query: 321 SIPHEQLDEINSVLERDFMIRAIHDVKGIDIGSNLIRYKAEVDFD 365
           S+P ++   +  ++ ++  +  +   + +  G N +   A++ FD
Sbjct: 244 SLPTDEEQRLRDIVMQNEHVDEVIGFRTVYFGPNEVIVFADLQFD 288


>UniRef50_Q5FU46 Cluster: Cation efflux system protein; n=1;
           Gluconobacter oxydans|Rep: Cation efflux system protein
           - Gluconobacter oxydans (Gluconobacter suboxydans)
          Length = 320

 Score = 94.7 bits (225), Expect = 4e-18
 Identities = 69/230 (30%), Positives = 109/230 (47%), Gaps = 14/230 (6%)

Query: 104 SGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMAD 163
           S +VV  A+G+N      K  A   TGS ++ +E +HS  D  NQL+L  G+ ++   A 
Sbjct: 6   STKVVFIALGVNLAIACVKGVAALLTGSAAMLAETVHSFVDCGNQLLLLVGMKRAAAPAT 65

Query: 164 PDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPL-------HDF--YWA- 213
            +HP G+    Y  +L+    +F  G   S + G   +  P  +       H F  +W  
Sbjct: 66  KEHPLGHHRELYFWTLVVAGALFIGGGVASLHEGWEKVWHPAAMDQVRVLGHVFPGWWLN 125

Query: 214 YFVLGGAVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVI 273
             +LG +   EG   + A+ ++  G      SL+  + RS+DP + VVL ED AA+  + 
Sbjct: 126 VAILGISGSMEGYGFLAAMKSLPSG----KGSLWTMIRRSTDPGLFVVLFEDGAALVSLT 181

Query: 274 VAASCMAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIP 323
           +A     +S  TG  + D + S+L+G +L  VA  +       LVG S P
Sbjct: 182 IALVFTVLSVVTGWHVLDGVASLLIGVVLVIVAVLLTNETRSLLVGESSP 231


>UniRef50_Q838Z8 Cluster: Cation efflux family protein; n=4;
           Lactobacillales|Rep: Cation efflux family protein -
           Enterococcus faecalis (Streptococcus faecalis)
          Length = 311

 Score = 92.7 bits (220), Expect = 2e-17
 Identities = 69/267 (25%), Positives = 126/267 (47%), Gaps = 8/267 (2%)

Query: 101 KTRSGR-VVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSV 159
           K  SG   V+ A+  N    + K   +  +GS ++ +E IHS+ D  NQ++L +G  ++ 
Sbjct: 4   KKSSGMFAVIAALIANILVAISKFVGFALSGSTAMMNESIHSVVDCSNQVLLLFGNKRAS 63

Query: 160 QMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLG- 218
           +     H +G    +Y  S I    +F  G  L     +  +L P   H+      V+G 
Sbjct: 64  RGQSALHQFGEGRAKYFFSTIVATMLFFGGGALGVMEAIQKLLHPS--HEVENVAIVIGI 121

Query: 219 --GAVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAA 276
               ++ EG++L VA+  I++   E  +SL +++  S    + ++  ED  AV G+ +A 
Sbjct: 122 LIFGLLVEGSSLRVAMKEIKELNTE-KLSLLKFLRESRHSEILIIFTEDFCAVIGLCLAL 180

Query: 277 SCMAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLER 336
               ++  TG    DA+  +L+G +L   A F+       ++G S+    L +I +  +R
Sbjct: 181 VGTLLTMVTGIAAFDAISGLLIGLLLMCAAIFLAKEFYSLIIGESVTATDLAKIKTAFDR 240

Query: 337 DFMIRAIHDVKGIDIGSNLIRYKAEVD 363
             + + I DVK + +G   I   A++D
Sbjct: 241 ADVEKLI-DVKTVHLGPTEILVAAKID 266


>UniRef50_A1A1Q0 Cluster: Cation transporter; n=3;
           Bifidobacterium|Rep: Cation transporter -
           Bifidobacterium adolescentis (strain ATCC 15703 / DSM
           20083)
          Length = 341

 Score = 90.6 bits (215), Expect = 7e-17
 Identities = 70/265 (26%), Positives = 126/265 (47%), Gaps = 15/265 (5%)

Query: 79  LRDYRREMSHTRSKDNVEEVGLKTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSEC 138
           + + R     + + +N+ EV      G  V  A+G N    + KL A F+TGS ++ SE 
Sbjct: 1   MSESRDPAGDSTTTNNMGEVREAEHQGAAVKAALGANIGVAIAKLLAAFFTGSSAMLSES 60

Query: 139 IHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGV 198
           +HS+AD  N+++L  G   S +  D DHP+G    +Y++S +    +F VG   S    V
Sbjct: 61  VHSIADCSNEIVLMVGGRFSKRKTDGDHPFGLYRAKYLASFVVATLLFFVGGFFSTSEAV 120

Query: 199 TGIL----DPQPLHD-----FYWAYFVLGGAVVSEGATLMVALSAIRKGAREAN---MSL 246
             ++    DP  L D        A+ V+  +   EG  L  ++    +     N   M +
Sbjct: 121 KKLVAISADP-ALRDVNRMELLVAFIVVVISACLEGFGLHQSIKEANERMERTNTPRMGV 179

Query: 247 YEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGTILGGVA 306
           + +  R+    +  V++EDT A+ G+  A   + ++    + + DALG ++VG +L  V 
Sbjct: 180 FRFWRRTKSAELASVIMEDTLALIGLAFAGLGIGLAIALDDEVFDALGGLMVGLVL-IVG 238

Query: 307 SFIILSNVGA-LVGRSIPHEQLDEI 330
           S ++    G+ L+G ++  +   +I
Sbjct: 239 SLLLAFKSGSLLIGEAVDSDTRGKI 263


>UniRef50_A5ZXZ3 Cluster: Putative uncharacterized protein; n=1;
           Ruminococcus obeum ATCC 29174|Rep: Putative
           uncharacterized protein - Ruminococcus obeum ATCC 29174
          Length = 391

 Score = 83.4 bits (197), Expect = 1e-14
 Identities = 71/257 (27%), Positives = 120/257 (46%), Gaps = 19/257 (7%)

Query: 112 IGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYT 171
           IG+N   F  K  A   +GS ++ ++  ++L+D  + +I   G   S Q  DP+HP+G+ 
Sbjct: 36  IGLNILLFFGKWLAGTISGSIAITADAFNNLSDAGSSIITLIGFRLSGQEPDPEHPFGHG 95

Query: 172 NMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVA 231
            M Y+S L+  V I  +G  L     +  +  P+P+     +  V G  +    A+++V 
Sbjct: 96  RMEYISGLLVSVAILVMGFEL-IGSSIGKLRSPEPIES---SALVFGILI----ASILVK 147

Query: 232 LSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPD 291
           L          N SL + +  ++  + +V  L DT A   V++A     IS+YTG  L  
Sbjct: 148 LYMFFY-----NHSLSKKIESAAMKATSVDSLSDTVATTLVLIAT---LISKYTGLLLDG 199

Query: 292 ALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDVKGIDI 351
             G ILVG  +       +   +  L+G+    E +DE+  ++    M+  +HD+   D 
Sbjct: 200 WFG-ILVGLFILYTGGSTLKETIDLLLGQPPKQEFIDEVKEIVLGHSMVHGVHDLIVHDY 258

Query: 352 GSN--LIRYKAEVDFDG 366
           G    +I   AEVD +G
Sbjct: 259 GPGRVMISLHAEVDVNG 275


>UniRef50_Q5UX98 Cluster: Cation efflux system protein; n=3;
           Halobacteriaceae|Rep: Cation efflux system protein -
           Haloarcula marismortui (Halobacterium marismortui)
          Length = 304

 Score = 80.6 bits (190), Expect = 7e-14
 Identities = 81/303 (26%), Positives = 135/303 (44%), Gaps = 37/303 (12%)

Query: 101 KTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQ 160
           +T   RV L  +G+N    L K   W  TGS ++ SE ++S ADT   L++  G++ + +
Sbjct: 4   RTTLRRVGLLVLGVNLLLVLLKAGVWLTTGSFAVQSEAVNSAADTAYSLVIVAGLYLTTR 63

Query: 161 MADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGA 220
             D +HP+G+  +    SL    GIF  G G   ++  T +L               G  
Sbjct: 64  PPDFEHPHGHERIEPFVSLFVAAGIFAAG-GFVLWNAGTALLT--------------GNI 108

Query: 221 VVSEG--ATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASC 278
            V++G  A L++A SA+ K A      LY Y +R+     +  L+         I+ A  
Sbjct: 109 SVTQGPAAVLVLAFSAVAKYA------LYRYCLRAGTDRNSPALIATAKDNRNDILTAGA 162

Query: 279 MAIS---QYTGNPLPDALGSILV--GTILGGVASFIILSNVGALVGRSIPHEQLDEINSV 333
             +       G P+ D L +++V  G I  G+   ++  NV  LVG + P +   EI   
Sbjct: 163 ALVGVGGAMAGYPIADPLAALVVAIGIIYTGIE--VVQENVTYLVGGAPPEDLRREILRR 220

Query: 334 LERDFMIRAIHDVKGIDIGSNL-IRYKAEVDFDGRALTRSYLEKHDL-NALLEDMKKIDT 391
                 +   HDV    +G  + +    EV+ D   LT    E HD+  A+++ ++++  
Sbjct: 221 ALDHPKVSGAHDVIAHYVGPEIDVSLHIEVEGD---LT--LFEAHDIETAVIKSIEELPE 275

Query: 392 IDD 394
           +DD
Sbjct: 276 VDD 278


>UniRef50_A5FSC2 Cluster: Cation diffusion facilitator family
           transporter precursor; n=3; Dehalococcoides|Rep: Cation
           diffusion facilitator family transporter precursor -
           Dehalococcoides sp. BAV1
          Length = 311

 Score = 80.2 bits (189), Expect = 1e-13
 Identities = 71/255 (27%), Positives = 116/255 (45%), Gaps = 17/255 (6%)

Query: 100 LKTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSV 159
           + TR  R    +I  N      K    F TGS S+ +E IHS  D +  +I  +G+  S 
Sbjct: 1   MATRKTRAASFSIASNSTLIAMKTVVGFVTGSVSILAEAIHSTLDLIAAVIAFFGVKASD 60

Query: 160 QMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGG 219
           + AD DHPYG+     VS  +  V IF V +    Y  V  ++         W   ++G 
Sbjct: 61  KPADIDHPYGHGKWENVSGTVEAVLIF-VAAIWIIYEAVNRLIGGSAPEMLEWGVVIMGI 119

Query: 220 AVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCM 279
           +VV   A  +V+   ++K A E      + V   +D S    L  D    AGV+V    +
Sbjct: 120 SVV---ANTLVS-RYLKKIAHET-----DSVALEADAS---HLTTDVITSAGVLVG---L 164

Query: 280 AISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVL-ERDF 338
            + + TG  + D + ++LV  ++   A  I+  + GALV   +P E+++ I S++ E   
Sbjct: 165 VLVKITGWVILDPIVALLVALLIIKAAWDILNKSFGALVDARLPKEEVEAITSLINEHTS 224

Query: 339 MIRAIHDVKGIDIGS 353
            +   H+++    GS
Sbjct: 225 KLVEFHNLRTRKAGS 239


>UniRef50_Q92AW3 Cluster: Lin1805 protein; n=17; Bacillales|Rep:
           Lin1805 protein - Listeria innocua
          Length = 321

 Score = 79.4 bits (187), Expect = 2e-13
 Identities = 59/231 (25%), Positives = 105/231 (45%), Gaps = 6/231 (2%)

Query: 96  EEVGLKTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGI 155
           E +GL     +  LTA  +N    + K   +F+TG+ ++F+E +HSL D  NQ  +  G 
Sbjct: 3   ELLGLLKEGNKSALTAALVNTIVSIIKGVTYFFTGNIAMFAETLHSLGDAANQFFVFIGS 62

Query: 156 HKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYF 215
             S +      P+G+  M  +  L+  V +  + +  +   G   I+DP     F     
Sbjct: 63  ALSKKRPTKRFPHGFGRMVNL-VLLGAVIVVGIMAFETIREGFAHIIDPTSSTGFLINLV 121

Query: 216 VLGGAVVSEGATLMVALSAIRK--GAREANMSLYE---YVMRSSDPSVNVVLLEDTAAVA 270
           VL    + E + L+ A+  I    G     +SL++     +  +  +  +V LED+ A  
Sbjct: 122 VLLLCTILEFSVLVKAMHEIAHDVGLESKGLSLFKDSILNLGKAKAATKLVFLEDSVATG 181

Query: 271 GVIVAASCMAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRS 321
           G ++A   + IS YT     + + S+L+G ++  V   + L N   ++G S
Sbjct: 182 GGLLAMIAVIISHYTPFHQAEGIASMLIGVMMFIVVGKVFLDNAAGVIGES 232


>UniRef50_A0DMX0 Cluster: Chromosome undetermined scaffold_57, whole
           genome shotgun sequence; n=2; Paramecium
           tetraurelia|Rep: Chromosome undetermined scaffold_57,
           whole genome shotgun sequence - Paramecium tetraurelia
          Length = 489

 Score = 76.2 bits (179), Expect = 2e-12
 Identities = 72/331 (21%), Positives = 142/331 (42%), Gaps = 23/331 (6%)

Query: 122 KLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLIS 181
           K  A++ T   + ++E   S+ D  N +IL       +   +   PYG   ++++ +LI 
Sbjct: 56  KFAAYYITNQQTFWAELTRSMIDASNHVILFATQIILIMGPNKQFPYGIEKVKHLVALIP 115

Query: 182 GVGIFCVGSGLSFYHGVTGILD----PQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRK 237
                  G+ +S Y     I +       +H   W    L   ++S G    V    IR 
Sbjct: 116 SALFLYFGASIS-YESFLNIYNYGHYVGEIHSNAWG---LALYLLSIGIETSVVFKNIRD 171

Query: 238 GA-----REANMSLYEY---VMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPL 289
                   E    L++    V +  DP +  +L E+   +   ++     A +       
Sbjct: 172 AQAVDSNEEIKKGLFKQFLSVFQKKDPVLQAILYENAITLGSTLIPLLSSAFTLIYPTHA 231

Query: 290 PDALGSILVGTILGGVASFIILSNVGALVG-RSIPHEQLDEINSVLERDFMIRAIHDVKG 348
            + +GS+ +G I   +A  +   N+ +L+G +SI   ++ +I  +++++  +  I + K 
Sbjct: 232 FEIVGSLAIGLIQLQLAYHLSAKNLSSLMGEQSISDFEVKKILEIIKQNQYVEKIQNEKA 291

Query: 349 IDIGSNLIRYKAEVDFDGRALTR----SYLEKHDLNALLEDMKKIDTIDDVETFLLKHGE 404
           + +GS   R+ AE+ F+ + + +     YLE+ D     E  +  D  + ++  L +  E
Sbjct: 292 VMLGSRKFRFSAEITFNIKQINQDTESKYLERFDKVIYSESYR--DREEYLQELLREIQE 349

Query: 405 NIVDMLGGEIDRIELKLRKKFPQIRHCDLEI 435
            ++  L  +I +IE  +R +FP   H D EI
Sbjct: 350 YVLASLHIQIQKIESAIRNEFPNCIHLDFEI 380


>UniRef50_UPI00006CBFC4 Cluster: cation efflux family protein; n=1;
           Tetrahymena thermophila SB210|Rep: cation efflux family
           protein - Tetrahymena thermophila SB210
          Length = 585

 Score = 74.1 bits (174), Expect = 6e-12
 Identities = 77/387 (19%), Positives = 173/387 (44%), Gaps = 25/387 (6%)

Query: 70  QDVFTVKRRLRDYRREMSHTRSKDNVEEVGLKTRSG--RVV--LTAIGINGCNFLFKLCA 125
           ++ F  +++L ++ +++ +T   D  ++   K +     ++  + +IGI G   LF+   
Sbjct: 79  EEKFDPEQKLAEFEKKVKNTNLNDTRKKFRFKYQQTIYNILPNMMSIGI-GLQLLFQFYL 137

Query: 126 WFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYV-----SSLI 180
           +F     +  +E   S  D VN L+L +  +  V+ +   +P G  N++ +     SSL 
Sbjct: 138 YFKRSVGTFLAELCRSSIDAVNHLVLYFANYIDVKPSKR-YPQGLENIKQLIVLIPSSLF 196

Query: 181 SGVGIFCVGSGLSFYHGVTGILDPQPLHDF----YWAYFVLGGAVVSEGATLMVALSAIR 236
              G + + S  + Y      +  Q  + +    Y A F +  +V++      + +  I 
Sbjct: 197 VSFGAYTIYSAFTEYLAAGPAVAAQSDNIYSILLYLASFCIEISVIAYNIRDSLKMQNIN 256

Query: 237 KGAR-EANMSLYEYV---MRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDA 292
              +    +SL++ +   +   DP +  +L E+   +  + V       +    + LP+ 
Sbjct: 257 STQQTNQKLSLFQIMKTLVAKKDPLLQAILYENMITLMSMSVPLMVGISNMIIPSNLPEF 316

Query: 293 LGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDVKGIDIG 352
           +G I++G+I   +   +       ++G+S+  E +++I++ + ++  +++I D KGI  G
Sbjct: 317 IGQIVIGSIQLLLGQRLFKEVASTILGKSVDEETMNDIHNEIMKNPYVKSIRDEKGIMSG 376

Query: 353 SNLIRYKAEVDFDGRALTRSYLEKH----DLNALLEDMKKIDTIDDVETFLLKHGENIVD 408
           S   +Y A V++D   L    +E +    D     +D K  D  +++E  +      ++ 
Sbjct: 377 SVRFKYYAIVEYDFEQLNEDAMEDYRQMSDYIIYSQDYK--DRQEELEELMESFPIRLLK 434

Query: 409 MLGGEIDRIELKLRKKFPQIRHCDLEI 435
            +  +   I   ++ K+PQ  + DL I
Sbjct: 435 EVKRQEQLILESIKIKYPQCDYLDLNI 461


>UniRef50_A0KRS9 Cluster: Cation diffusion facilitator family
           transporter; n=10; Alteromonadales|Rep: Cation diffusion
           facilitator family transporter - Shewanella sp. (strain
           ANA-3)
          Length = 299

 Score = 71.7 bits (168), Expect = 3e-11
 Identities = 62/246 (25%), Positives = 112/246 (45%), Gaps = 20/246 (8%)

Query: 120 LFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSL 179
           L KL AW Y+GS S+ +    S AD +  +I    I  ++  AD DH YG+     ++SL
Sbjct: 27  LIKLLAWLYSGSASMLASLTDSFADALASIINFIAIRYAIVPADHDHRYGHGKAEPLASL 86

Query: 180 ISGVGIFCVGSG-LSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKG 238
                 F +GS  L  ++G   +L+P P+      +  LG  V      L +AL  ++K 
Sbjct: 87  AQSA--FIMGSAFLLLFYGGERLLNPAPVE-----HATLGVVVSVVAIVLTLALVMLQKR 139

Query: 239 AREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILV 298
           A  A          S+    + +  +    + G ++ A  + +SQY G    D L ++L+
Sbjct: 140 ALAAT--------NSTVVEADSLHYKSDLFLNGAVLLA--LVLSQY-GWWWADGLFAVLI 188

Query: 299 GTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDVKGIDIGSNL-IR 357
              +G  A  +   ++ AL+ R +  +    I  + + D  ++ +HD++    G  + I+
Sbjct: 189 ACYIGQQAFDLGYRSIQALLDRELDEDTRQRIKQIAKEDSRVQGLHDLRTRQAGKTIFIQ 248

Query: 358 YKAEVD 363
           +  E+D
Sbjct: 249 FHLELD 254


>UniRef50_Q3IQA7 Cluster: Transporter 38; n=1; Natronomonas
           pharaonis DSM 2160|Rep: Transporter 38 - Natronomonas
           pharaonis (strain DSM 2160 / ATCC 35678)
          Length = 323

 Score = 65.7 bits (153), Expect = 2e-09
 Identities = 86/316 (27%), Positives = 136/316 (43%), Gaps = 39/316 (12%)

Query: 96  EEVGLKT-----RSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTV-NQL 149
           EE GL+T     R  R  L  +  N    L +       GS +L ++  HS+AD V + +
Sbjct: 7   EEAGLETETARRRFSRASLVNVAGNAVKILVEGAVGLAFGSVALLADAAHSVADLVASAV 66

Query: 150 ILAYGIHKSVQMADPD--HPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPL 207
           +L +G  +SV   DPD  HP+G+  +  +++L  G  I  +G  L FY   TG++   P 
Sbjct: 67  VLVWG--RSVY-TDPDENHPHGHQRVEPLAALFVGSLIVLLGLNL-FYESATGLV-AGPE 121

Query: 208 HDFYWAYFVLGGAVVSEGATLMVALSAIRKGAREANMSLYEY---VMRSSDPSVNVVLLE 264
             F+    +L GA++   A + +               LY Y   +  S   S    L  
Sbjct: 122 VQFHP---LLVGALLFAMADMYL---------------LYWYTTHINESVGSSALEALAI 163

Query: 265 DTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPH 324
           D        +AA C  I  + G PL DA+   LV  ++      I   NV  LVG S   
Sbjct: 164 DCRNDIYTTIAALCGVIGVFFGYPLFDAVAGGLVSVLVVYQGFEISRENVSYLVGASPSD 223

Query: 325 EQLDEINSVLERDFMIRAIHDVKGIDIGSNLIRYKAEVDFDGRALTRSYLEKHDLNA-LL 383
           +Q   +   L     +   HDV     G++ I  +A V+ DG     + +E HD+   L+
Sbjct: 224 QQRQRVVETLTDHPAVHGAHDVAVFYDGTD-IEVEAHVEVDGEL---TLVEAHDIETELV 279

Query: 384 EDMKKIDTIDDVETFL 399
             ++ ++++ DV   L
Sbjct: 280 SALRSLESVGDVHLHL 295


>UniRef50_A6NR09 Cluster: Putative uncharacterized protein; n=1;
           Bacteroides capillosus ATCC 29799|Rep: Putative
           uncharacterized protein - Bacteroides capillosus ATCC
           29799
          Length = 392

 Score = 64.1 bits (149), Expect = 7e-09
 Identities = 74/306 (24%), Positives = 135/306 (44%), Gaps = 30/306 (9%)

Query: 94  NVEEVGLKTRSGRVVLTAIGINGCNFLF---KLCAWFYTGSHSLFSECIHSLADTVNQLI 150
           NV++  ++ R G  +  A+GI   N L    K+ A   TGS ++ ++  ++L D  + ++
Sbjct: 15  NVQDPQVRQRYG-TLSGAVGIF-LNLLLSAGKMIAGLITGSIAITADAFNNLTDAGSSVV 72

Query: 151 LAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDF 210
              G   + + AD DHP+G+  + Y+S L   V I  VG  L+    V  I+ P+P+ +F
Sbjct: 73  TLVGFRMAGKQADDDHPFGHGRIEYLSGLAVSVVILLVGLELA-KSSVEKIIHPEPV-EF 130

Query: 211 YWAYFVLGGAVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVA 270
            W             A +++A   ++      N SL   +  ++  +     L D  A +
Sbjct: 131 SWL-----------SAGILIAAICVKLWMSYFNRSLSRRIGSAAMAATATDSLSDAVATS 179

Query: 271 GVIVAASCMAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEI 330
            V+++A    I ++TG  + DA   ILV   +           +  L+G+S   E + +I
Sbjct: 180 AVLLSA---IIGKFTGVNI-DAWAGILVALFILRAGWGAAKDTLNPLLGQSPDPELVRDI 235

Query: 331 NSVLERDFMIRAIHD--VKGIDIGSNLIRYKAEVDFDGRALTRSYLEKHD-LNALLEDMK 387
              +     +  IHD  +     G +++   AEV           +E HD ++A+  ++K
Sbjct: 236 ERTVLAHPQVVGIHDMIIHDYGPGRSMMSLHAEVPAGS-----DIMEVHDEIDAIERELK 290

Query: 388 KIDTID 393
               ID
Sbjct: 291 AKYRID 296


>UniRef50_A6DS63 Cluster: MMT1 protein; n=1; Lentisphaera araneosa
           HTCC2155|Rep: MMT1 protein - Lentisphaera araneosa
           HTCC2155
          Length = 339

 Score = 64.1 bits (149), Expect = 7e-09
 Identities = 65/263 (24%), Positives = 111/263 (42%), Gaps = 21/263 (7%)

Query: 122 KLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLIS 181
           K  AW +TGS +L S    S  D +  ++    +  S++ AD DH +G+     ++++  
Sbjct: 62  KFIAWNFTGSATLLSSLTDSSLDFLASMLSFAVLTYSLKPADEDHRFGHGKAEGLAAVFQ 121

Query: 182 GVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGARE 241
              +   G  + +  GV  + DP P+         +G  + S   TL  AL   ++    
Sbjct: 122 SGIVLIAGLSVLYQAGVR-LFDPAPMEK---TGLAIGIMLFSLALTL--ALITYQQKVYN 175

Query: 242 ANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGTI 301
              SL     R+         + D  A AG IVA     I  Y G    DA+G I+V  +
Sbjct: 176 ITGSLVVKADRAH-------FVSDILANAGAIVA----LILAYVGVSYADAIGGIVVALL 224

Query: 302 LGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDVKGIDIGSNLIRYKAE 361
           +   A  +    +  L+   +P E + E   ++E +  I   HDV+    G  L  ++  
Sbjct: 225 IVKAAWEVFEHALEMLLDHELPQEDVKEFEQMIEDERNILGYHDVRTRRSGKTLF-FQVH 283

Query: 362 VDFDGRALTRSYLEKHDLNALLE 384
           ++F+ +AL     E HD+   +E
Sbjct: 284 LEFEDQALLS---EAHDIADRIE 303


>UniRef50_O28143 Cluster: Conserved hypothetical transmembrane
           protein; n=1; Archaeoglobus fulgidus|Rep: Conserved
           hypothetical transmembrane protein - Archaeoglobus
           fulgidus
          Length = 283

 Score = 63.3 bits (147), Expect = 1e-08
 Identities = 63/281 (22%), Positives = 115/281 (40%), Gaps = 20/281 (7%)

Query: 122 KLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLIS 181
           KL A+F +G  ++ ++  HS+ D    LIL      + + AD  HP+G+   R V+SL  
Sbjct: 15  KLYAYFLSGFTAILADAFHSVIDITMILILLLSERYAEKEADYQHPFGHEMARNVASLAV 74

Query: 182 GVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGARE 241
           GVG            G+  +L P         Y  +  A+ +E A L + + A    AR 
Sbjct: 75  GVGFITFMFFELMKEGLLKVLHPAS------GYSNVEVALGAEVAVLALLVIAALISARR 128

Query: 242 ANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGTI 301
           + +     ++ S + S++ +     AA+ GV +         + G P+ D + +I +  I
Sbjct: 129 SGILNRTLLVESLNDSLSTL-----AAIVGVGLV--------WAGYPIFDGIATIAIAFI 175

Query: 302 LGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDVKGIDIGSNLIRYKAE 361
           +   +  ++  N   L+G S   +    +         ++ +HD+ G+  G N +     
Sbjct: 176 IFYNSFRLVRDNARLLIGMSPSEDFYRSVEDACLEIERVKGVHDMVGVYTGENSVHLDLH 235

Query: 362 VDFDGRALTRSYLEKHDLNALLEDMKKIDTIDDVETFLLKH 402
           V  DG A+T    +K  +      M K   +  +      H
Sbjct: 236 VTVDG-AMTIEEADKLSVEIAEAIMAKHPEVKHISVHFCPH 275


>UniRef50_A1THH9 Cluster: Cation diffusion facilitator family
           transporter precursor; n=1; Mycobacterium vanbaalenii
           PYR-1|Rep: Cation diffusion facilitator family
           transporter precursor - Mycobacterium vanbaalenii
           (strain DSM 7251 / PYR-1)
          Length = 300

 Score = 62.5 bits (145), Expect = 2e-08
 Identities = 52/231 (22%), Positives = 105/231 (45%), Gaps = 16/231 (6%)

Query: 106 RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD 165
           R +L ++         K  A   TGS    S+ + S  + V  ++  + +  + +  D D
Sbjct: 16  RFMLLSLAAAIVTMALKAGAAVITGSVGFLSDALESGVNLVAAVVALWALRVAARPRDAD 75

Query: 166 HPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEG 225
           H +G+    Y+S+L+ G  IF   + +  +  V  ++ P PL         L  +  + G
Sbjct: 76  HHFGHGKAEYLSALVEGAMIFVAATAI-IWSAVERLMSPAPL---VQPGVGLALSTAAAG 131

Query: 226 ATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYT 285
             L+V ++ +R G R  +++L          +    L+ D    AGVIV  S +A++ + 
Sbjct: 132 VNLVVGVTLLRMGRRHRSVTLV---------ADGKHLMTDVWTSAGVIVGISLVALTDW- 181

Query: 286 GNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLER 336
             PL D + ++ VG  +      ++  ++ +L+  ++P +    +N+VL+R
Sbjct: 182 -YPL-DPIVALAVGVNILWTGYRLLRGSMSSLLSAALPEQDHAAVNAVLDR 230


>UniRef50_P74068 Cluster: Uncharacterized transporter sll1263; n=2;
           Chroococcales|Rep: Uncharacterized transporter sll1263 -
           Synechocystis sp. (strain PCC 6803)
          Length = 310

 Score = 62.1 bits (144), Expect = 3e-08
 Identities = 55/211 (26%), Positives = 92/211 (43%), Gaps = 16/211 (7%)

Query: 122 KLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLIS 181
           KL A+  TGS  L S+ + S  +  + ++  + +  +   AD +HP+G++   Y SS + 
Sbjct: 24  KLGAYAITGSVGLLSDALESTVNLASAIVAFWALSLAATPADSEHPFGHSKAEYFSSGLE 83

Query: 182 GVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGARE 241
           G  IF    G+  Y  V  +L P+PL        +   A    G    VA    R G R 
Sbjct: 84  GAFIFVAALGIG-YSAVERLLSPRPLDQNALGIALAIAATALNGT---VAWILWRAGKR- 138

Query: 242 ANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGTI 301
               L    +R+        L+ D     GV+VA + + +   TG    D L ++ VG  
Sbjct: 139 ----LNSIALRADSQH----LMTDVWTSVGVVVAVALIFV---TGWEWLDPLIALGVGFN 187

Query: 302 LGGVASFIILSNVGALVGRSIPHEQLDEINS 332
           +    + ++   + +L+ +S+P  QL  I S
Sbjct: 188 VLWTGTHLLRETISSLMDQSLPPAQLQAITS 218


>UniRef50_A4EAI9 Cluster: Putative uncharacterized protein; n=1;
           Collinsella aerofaciens ATCC 25986|Rep: Putative
           uncharacterized protein - Collinsella aerofaciens ATCC
           25986
          Length = 393

 Score = 60.5 bits (140), Expect = 9e-08
 Identities = 70/300 (23%), Positives = 127/300 (42%), Gaps = 22/300 (7%)

Query: 91  SKDNVEEVGLKTRSGRVV-LTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQL 149
           S+    +   +T +G    L  IG+N    L K  A    GS SL ++  ++L+D  + +
Sbjct: 15  SESEPVDTSCRTNAGFAASLICIGLNITLCLAKGIAGLLAGSVSLIADAFNNLSDASSNI 74

Query: 150 ILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHD 209
           +   G   + + AD  HPYG+    Y++ L   V +  VG  L     VT I+ P P   
Sbjct: 75  VSLLGFRLASRPADEGHPYGHGRYEYLAGLFVAVLVCAVGINL-ILESVTKIIKPSPT-- 131

Query: 210 FYWAYFVLGGAVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAV 269
              AY  +  A ++    + + ++A  +     N    E ++ ++  S N V+       
Sbjct: 132 ---AYTFISLAALATSMLVKLWMAAFNRTL--GNRIDSETLIATAQDSKNDVI------T 180

Query: 270 AGVIVAASCMAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDE 329
           +G ++AA+   ISQ TG  L D    + VG  +      ++ + +  L+G++   + +  
Sbjct: 181 SGSVLAAA--LISQATGFDL-DGWAGLGVGIFICISGMGLVRNAISPLLGQAPDPKLVQA 237

Query: 330 INSVLERDFMIRAIHDVKGIDIGSNLIRYKAEVDFDGRALTRSYLEKHD-LNALLEDMKK 388
           I   +     +   HD+   D G       A V+  G        E H+ L+ +  D+K+
Sbjct: 238 IRDKIMSYPQVLGTHDLMVHDYGPGRQFASAHVEMPGEG---DAFEHHEILDTIEHDIKR 294


>UniRef50_Q2SCG7 Cluster: Predicted Co/Zn/Cd cation transporters;
           n=1; Hahella chejuensis KCTC 2396|Rep: Predicted
           Co/Zn/Cd cation transporters - Hahella chejuensis
           (strain KCTC 2396)
          Length = 383

 Score = 60.1 bits (139), Expect = 1e-07
 Identities = 59/257 (22%), Positives = 109/257 (42%), Gaps = 17/257 (6%)

Query: 101 KTRSG-RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSV 159
           KTR+  RV L  + ++    L K+       SH+L ++ IHS  D    +++      S 
Sbjct: 9   KTRAAHRVTLIGMILDIALGLLKIIVGVLAQSHALVADGIHSFTDAGTDILVIVITRYSH 68

Query: 160 QMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGG 219
           Q  D +HPYG+     + +++ G  +  V +G   Y  +  + +        W   +   
Sbjct: 69  QKPDREHPYGHGKFETLGTVVLGSMLIAV-AGAMAYDSILRLWEKDAQVAPGWPALLAAS 127

Query: 220 AVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCM 279
             ++    +      I K  R   +    +  RS   S  VVL+    A+ GVI      
Sbjct: 128 LSIAGKEWIYRYTLDIGKKLRSDLIIANAWHSRSDALSSVVVLI----ALLGVI------ 177

Query: 280 AISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFM 339
                 G P  DAL +I+V  ++G +   +   +V  LV  ++P +Q+  I  +      
Sbjct: 178 -----AGFPWVDALAAIIVAILIGKIGIELAGKSVKELVETALPEDQVHAIRELALSVEG 232

Query: 340 IRAIHDVKGIDIGSNLI 356
           +R +HD++G  +G +++
Sbjct: 233 VRGVHDLRGRYVGPDIV 249


>UniRef50_A6VZC2 Cluster: Cation diffusion facilitator family
           transporter; n=2; Marinomonas|Rep: Cation diffusion
           facilitator family transporter - Marinomonas sp. MWYL1
          Length = 388

 Score = 59.7 bits (138), Expect = 1e-07
 Identities = 54/231 (23%), Positives = 104/231 (45%), Gaps = 25/231 (10%)

Query: 120 LFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSL 179
           L K+ A +++ S +L ++ IHSL+D V  + + +    S Q  D +HPYG+     ++++
Sbjct: 27  LAKIVAGYFSQSQALIADGIHSLSDLVTDVFVYFASANSRQGPDENHPYGHLRFETLTTV 86

Query: 180 ISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGA 239
             G+ +  V  G++ Y  +T    P     F W            G   +VA  AI++  
Sbjct: 87  FLGIVLIVVALGIA-YESITA---PASQAQFTW-----------YGLAALVATIAIKE-- 129

Query: 240 REANMSLYEYVMRSSDPSVNVVLLED---TAAVAGVIVAASCMAISQYTGNPLPDALGSI 296
                +++ Y  ++ D   + +L+ +   + + A   VA     I  Y G    D + SI
Sbjct: 130 -----AIFHYTKKAGDKIGSKMLVANAWHSRSDALSSVAVLIGLIGVYFGYGWADMVASI 184

Query: 297 LVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDVK 347
           +V  ++G +A  ++  N+  LV  +   + + +I         + A HDV+
Sbjct: 185 VVALLIGKMAVSMVWENLAELVDTAPDPKLIAQIKETANSLKHVMAPHDVR 235


>UniRef50_A4E9J2 Cluster: Putative uncharacterized protein; n=1;
           Collinsella aerofaciens ATCC 25986|Rep: Putative
           uncharacterized protein - Collinsella aerofaciens ATCC
           25986
          Length = 386

 Score = 59.7 bits (138), Expect = 1e-07
 Identities = 60/250 (24%), Positives = 111/250 (44%), Gaps = 20/250 (8%)

Query: 129 TGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCV 188
           +GS S+ ++ +++L+D  + ++   G   + + ADP+HPYG+    Y+S L+    +  +
Sbjct: 44  SGSVSIVADAMNNLSDASSNIVSVLGFKLASKPADPEHPYGHGRYEYLSGLVVAALVLLI 103

Query: 189 GSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGAREANMSLYE 248
           G  L     V  ++ P+P+    ++  ++   V+S    L +A    + G R  + +L+ 
Sbjct: 104 GVEL-VKSSVERVIHPEPVE---FSLALVAVLVLSMIVKLWMAALNQKLGDRIESETLH- 158

Query: 249 YVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGTILGGVASF 308
               ++  S N VL        G ++A  C  +SQ T   L DA   + VG  +G     
Sbjct: 159 ---ATAQDSKNDVL------ATGAVLA--CAIVSQVTHINL-DAWVGLAVGAYIGWSGFE 206

Query: 309 IILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDVKGIDIGSNLIRYKAEVDFDGRA 368
           +I   V  L+G++   + +  I   +     +  +HD+   D G       A  +    A
Sbjct: 207 LIQDTVSPLLGQAPDPKLVKHIRDKIMSYPGVLGVHDLMVHDYGPGRKFASAHAEMSAEA 266

Query: 369 LTRSYLEKHD 378
              S LE HD
Sbjct: 267 ---SPLESHD 273


>UniRef50_Q8VLX7 Cluster: CzrB protein; n=3; Thermus
           thermophilus|Rep: CzrB protein - Thermus thermophilus
          Length = 291

 Score = 59.3 bits (137), Expect = 2e-07
 Identities = 53/228 (23%), Positives = 107/228 (46%), Gaps = 18/228 (7%)

Query: 122 KLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLIS 181
           K  A+  TGS +L S+ + SL +    L     +  + +  D +HP+G+T   YVS+++ 
Sbjct: 20  KAFAYLLTGSVALLSDALESLVNVAAALAALLALRVARKPPDQNHPFGHTKAEYVSAVLE 79

Query: 182 GVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGARE 241
           GV +      ++    +  +L P PL         LG ++++     ++A   +++G R 
Sbjct: 80  GVLVVLAALWIA-REALPRLLHPVPLEGLGLG---LGVSLLASLLNGLLAYHLLKEGRRH 135

Query: 242 ANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGTI 301
            + +L      ++D      +L D     GV++    + ++  TG  + D L ++ V   
Sbjct: 136 RSPAL------TAD---GYHVLSDVLTSLGVVLG---VGLAGLTGLWVLDPLLALAVAGQ 183

Query: 302 LGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRA--IHDVK 347
           +  +   I+  +VG L+   +P E+++ I + L+     RA  +HD+K
Sbjct: 184 ILFLGYRIVRESVGGLMDEGLPPEEVERIRAFLQERIRGRALEVHDLK 231


>UniRef50_A7AEG5 Cluster: Putative uncharacterized protein; n=1;
           Parabacteroides merdae ATCC 43184|Rep: Putative
           uncharacterized protein - Parabacteroides merdae ATCC
           43184
          Length = 303

 Score = 58.8 bits (136), Expect = 3e-07
 Identities = 65/285 (22%), Positives = 125/285 (43%), Gaps = 17/285 (5%)

Query: 107 VVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDH 166
           V LT    N    +FK  A     S ++ ++ +HSL+D V  +I+   I+ S +  D  H
Sbjct: 13  VTLTGSLANFLLLVFKFVAGVLGHSSAMIADAVHSLSDFVTDVIVLLFINISSKPKDEGH 72

Query: 167 PYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEG- 225
            YG+     +++ I G+ + CVG+GL F+ G   +        FY+     G  + S G 
Sbjct: 73  DYGHGKYETLATTIIGIVLMCVGAGL-FWDGANKVF------GFYFG----GEQLESPGK 121

Query: 226 ATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYT 285
             L+ A+ +I        ++LY     +S   +       + A + +             
Sbjct: 122 IALIAAIISILIKETLYRLTLYVGKKENSQAVIANAWHHRSDAFSSIGTTLGIGGAILLG 181

Query: 286 GN-PLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIH 344
            N  + D + +++V  ++  VA  +++  +  L+ +S+P E  D+I S++     +R  H
Sbjct: 182 DNWRVLDPIAAVIVSILIVKVAFQLVIPAINDLLEKSLPTEVEDKILSIINETPEVRNPH 241

Query: 345 DVKGIDIGSNLIRYKAEVDFDGRALTRSYLEKHDLNALLEDMKKI 389
           ++    IG N    +  +  DG+ +T S    H+L   +E   ++
Sbjct: 242 NLCTRRIG-NDFAIEVHIRVDGQ-ITVS--RAHELTKEIESKLRL 282


>UniRef50_Q8Y4L4 Cluster: Lmo2423 protein; n=14; Bacillales|Rep:
           Lmo2423 protein - Listeria monocytogenes
          Length = 291

 Score = 58.4 bits (135), Expect = 3e-07
 Identities = 41/125 (32%), Positives = 62/125 (49%), Gaps = 7/125 (5%)

Query: 120 LFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSL 179
           + KL   F+TGS ++ SE IHS  D    +I  + I  S Q AD DHPYG+     ++  
Sbjct: 19  VLKLIVGFFTGSVAVISEGIHSSMDLFASIITFFSIRISNQPADEDHPYGHGKAENIAGT 78

Query: 180 ISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALS-AIRKG 238
           I  + IF  G  +     V  +++P  +      +  LG  V+  GA + + +S  I+K 
Sbjct: 79  IETLLIFVAGIWI-IVESVNKLVNPHEIR-----FPALGIMVMLFGAIVNIIVSRIIKKA 132

Query: 239 AREAN 243
           A EAN
Sbjct: 133 ADEAN 137


>UniRef50_Q6MQU1 Cluster: Cation efflux system protein; n=1;
           Bdellovibrio bacteriovorus|Rep: Cation efflux system
           protein - Bdellovibrio bacteriovorus
          Length = 345

 Score = 58.4 bits (135), Expect = 3e-07
 Identities = 51/219 (23%), Positives = 97/219 (44%), Gaps = 17/219 (7%)

Query: 119 FLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSS 178
           F  K+ A+  TGS ++ S+ + S+ + +  ++  + I  + Q AD +HPYG+    Y SS
Sbjct: 27  FAMKVFAYRLTGSTAVLSDALESIVNVIAAIVALFVIRFASQPADENHPYGHGKAEYFSS 86

Query: 179 LISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKG 238
              G G+    + +     V  ++  +P         ++GGA     A + +AL    K 
Sbjct: 87  AFEG-GMIFFAAIMIIGEAVKALIYHEPTQQLETGLLIVGGA-----ALVNLALGLYLKR 140

Query: 239 AREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILV 298
               + S     +++S   V    L D     GV+V    + +   TG    D + ++LV
Sbjct: 141 VGRTHQS---DALKASGAHV----LSDVLTTVGVMVGLGLVLL---TGIQWLDPVIAVLV 190

Query: 299 GTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERD 337
           G  L      I+  ++G L+ +  P   L+++   +E++
Sbjct: 191 GLQLAYAGFKIVRGSLGGLMDQQDP-ASLEQLAEAMEKN 228


>UniRef50_A6TSV8 Cluster: Cation diffusion facilitator family
           transporter; n=1; Alkaliphilus metalliredigens QYMF|Rep:
           Cation diffusion facilitator family transporter -
           Alkaliphilus metalliredigens QYMF
          Length = 296

 Score = 58.4 bits (135), Expect = 3e-07
 Identities = 55/238 (23%), Positives = 98/238 (41%), Gaps = 23/238 (9%)

Query: 122 KLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLIS 181
           K+      GS +L ++  HS +D +  L++  GI  + Q AD  HPYG+     ++S I 
Sbjct: 28  KIMVGLAAGSAALVADGFHSASDLIGTLVVMQGIKIAHQPADESHPYGHYRAETITSKIL 87

Query: 182 GVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGARE 241
            + +     GL  Y G+  +  P+                  E   L +AL ++      
Sbjct: 88  AIILILTAMGLG-YEGLQVLRSPE--------------LSPPEMLALYIALFSV-----I 127

Query: 242 ANMSLYEYVMRSSDPSVNVVLLED---TAAVAGVIVAASCMAISQYTGNPLPDALGSILV 298
           A   +Y+Y +R      +  ++ D     + A   +AAS   +    G P+ D L +I V
Sbjct: 128 AKEGIYQYNIRIGKRIKSSAIIADAWHARSDAFSSIAASIGIVGSILGYPIMDPLAAIFV 187

Query: 299 GTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDVKGIDIGSNLI 356
             ++      I + ++  L+  + P E LD I +       +  +HD+K    GS  +
Sbjct: 188 AFLILKTGVSIYVDSIKTLMDTAPPKEILDMIETAALAAEGVEDVHDIKVRQYGSKYL 245


>UniRef50_Q57891 Cluster: Uncharacterized transporter MJ0449; n=4;
           Euryarchaeota|Rep: Uncharacterized transporter MJ0449 -
           Methanococcus jannaschii
          Length = 283

 Score = 58.4 bits (135), Expect = 3e-07
 Identities = 67/291 (23%), Positives = 127/291 (43%), Gaps = 26/291 (8%)

Query: 107 VVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDH 166
           ++L+ +G N    L K+   +   S SL S+ IHSL+D +  +I   G+  + +  D  H
Sbjct: 8   LILSIVG-NILLGLIKIIIGYVYSSISLISDGIHSLSDVITSIIGIIGVKIASKPPDESH 66

Query: 167 PYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGA 226
           PYG++    + S   G+ +F     +  +  V  I+           Y    G V+   A
Sbjct: 67  PYGHSRFECLFSFFIGLALFFTAYEIGKF-AVERII-----------Y----GEVIEVNA 110

Query: 227 TLM-VALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYT 285
            ++ VA+ +I         SL+     +S   +       + A++ V+V    +   Q  
Sbjct: 111 IMVGVAILSIVVKELMTRYSLFVGKKLNSQVLIADAYHHRSDALSSVVVLVGLLL--QKF 168

Query: 286 GNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHD 345
           G    DA+  I+V  ++  VA  I L+N+  L GR+ P +  + I         +  +HD
Sbjct: 169 GIYYGDAIAGIIVALMIAKVAFDICLTNIDYLTGRAPPKKFFELIEKEALNVDKVIGVHD 228

Query: 346 VKGIDIGSNLIRYKAEVDFDGRALTRSYLEKHDLNALLEDMKKIDTIDDVE 396
           +K   +G   I  +  V+        S  E HD+   +++  +++++++VE
Sbjct: 229 IKAHYVGPR-IHVELHVEVPSNI---SAKEMHDIEVAVKN--RLESLENVE 273


>UniRef50_Q2BDX4 Cluster: Putative uncharacterized protein; n=2;
           Bacillus sp. NRRL B-14911|Rep: Putative uncharacterized
           protein - Bacillus sp. NRRL B-14911
          Length = 338

 Score = 58.0 bits (134), Expect = 5e-07
 Identities = 66/288 (22%), Positives = 128/288 (44%), Gaps = 11/288 (3%)

Query: 109 LTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPY 168
           + AIG N    + K  A   +GS ++ +  +HS AD +NQ  +  G   + +      P 
Sbjct: 34  IAAIG-NTVLTIAKGVAAAISGSGTMLATTLHSAADALNQGFVFIGSALAEKEPTKRFPT 92

Query: 169 GYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATL 228
           G+  +  +  L++ + +  + +  + + G   I  P+   +      ++  A+  +G  L
Sbjct: 93  GFGRVVNLFVLVAVI-VIAIMAYETIHKGWELIQHPKESTNILLNISIMLLAIGVDGFIL 151

Query: 229 MVALSAIRKGAR-EAN-MSLYEYVMRSS---DPSVNVVLLEDTAAVAGVIVAASCMAISQ 283
           + A+  I    R EA   S+     +++    P   +V  ED  A  G ++A   + ++ 
Sbjct: 152 VKAMKEINHETRSEAKGFSIVTTAFKNNGLASPPTRLVFYEDLIATFGALLALVSILLAH 211

Query: 284 YTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAI 343
           +TG    D +G+IL+G +L G+A  I   N   L+G + P    D + +++  D  +  I
Sbjct: 212 FTGFYFLDGVGTILIGLLLTGIAVKIGYENTIGLIGVAAPKIVEDRVANMILSDPDVVDI 271

Query: 344 HDVKGIDIGSNLIRYKAEVDFDGRALTRSYLEKHDLNALLEDMKKIDT 391
            D++ +  G    R+  E   + RA   S  +  D+   + D+   DT
Sbjct: 272 LDMRILQEGR---RFHVESYIELRA-GLSLADADDIKFRVRDLLLTDT 315


>UniRef50_A4J2G0 Cluster: Cation diffusion facilitator family
           transporter; n=3; Peptococcaceae|Rep: Cation diffusion
           facilitator family transporter - Desulfotomaculum
           reducens MI-1
          Length = 315

 Score = 58.0 bits (134), Expect = 5e-07
 Identities = 56/232 (24%), Positives = 99/232 (42%), Gaps = 17/232 (7%)

Query: 106 RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD 165
           +V   +I  N C  + KL      GS  + SE +HS  D +  LI    + +S + AD D
Sbjct: 10  KVARLSIISNTCLTIGKLVVGLSMGSVGVISEAVHSGLDLIASLIAFMAVRQSGKPADED 69

Query: 166 HPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGIL-DPQPLHDFYWAYFVLGGAVVSE 224
           H YG+     ++ ++  + I   G G+ F   V  IL     +    W   V+    +S 
Sbjct: 70  HHYGHGKYENLAGILEALLILVAGVGI-FIQAVPKILGGGGEIESLGWGAAVM---ALSA 125

Query: 225 GATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQY 284
           G   +++   I  G    + +L          +    L  D     GV      + ++ Y
Sbjct: 126 GVNFIISKRLIAVGKETDSPALV---------ADGWHLKTDVYTSLGVFAGLGTIYLTGY 176

Query: 285 TGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLER 336
           T   L D + +I+VG ++   +  +I  ++G ++  S+P E+ ++I  VL R
Sbjct: 177 T---LLDPIIAIIVGILILKASFDLIRESLGVILDVSLPPEEEEKIKEVLRR 225


>UniRef50_Q97K27 Cluster: Cation efflux system protein; n=1;
           Clostridium acetobutylicum|Rep: Cation efflux system
           protein - Clostridium acetobutylicum
          Length = 292

 Score = 57.6 bits (133), Expect = 6e-07
 Identities = 57/276 (20%), Positives = 120/276 (43%), Gaps = 22/276 (7%)

Query: 111 AIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGY 170
           +I  N    +FKL A     S S+ SE +HS  D +  LI  + I KS    D DHP+G+
Sbjct: 10  SIASNSMLIIFKLTAGITMNSISVLSEGVHSSIDLIASLIAFFSIKKSSLKEDDDHPFGH 69

Query: 171 TNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMV 230
                VS  +  + +    + +  Y     ++    + +     +++   ++S    L +
Sbjct: 70  GKYENVSGFVEAI-LIMFAAIMIIYEAFNKLVSNSHVKNIDSGIYIM---LISSAVNLFI 125

Query: 231 ALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLP 290
           ++  + K +++ N    E        +  + L  D     GV +    + + + T   + 
Sbjct: 126 SI-ILLKSSKDTNSIALE--------ADGMHLFTDFFTSLGVFLG---LVLLKLTNIKII 173

Query: 291 DALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDVKGID 350
           D++ + LV  ++   A  +I  ++  LV  S+  + +++I  ++++   I+  H ++   
Sbjct: 174 DSITAFLVAILIIKTAVDLIKKSLRDLVDSSLDKDDINKIVKIVKKYPNIKEYHKLRTRR 233

Query: 351 IGSNLIRYKAEVDFDGRAL-TRSYLEKHDLNALLED 385
            G+       E+D   + + T S  E HD+ + +ED
Sbjct: 234 CGNT-----REIDIHIQIVGTDSLKETHDICSSIED 264


>UniRef50_Q8RDD5 Cluster: Predicted Co/Zn/Cd cation transporters;
           n=4; Thermoanaerobacter|Rep: Predicted Co/Zn/Cd cation
           transporters - Thermoanaerobacter tengcongensis
          Length = 288

 Score = 57.6 bits (133), Expect = 6e-07
 Identities = 62/276 (22%), Positives = 116/276 (42%), Gaps = 22/276 (7%)

Query: 106 RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD 165
           +  L ++  N      KL A     S  + SE IHS  D +  +I  + I K+ + AD D
Sbjct: 5   KAALLSVVSNSFLITVKLVAGILMHSIGVISEAIHSSIDLIASIIAFFSIRKAAKPADDD 64

Query: 166 HPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEG 225
           HP+G+     VS  +  + IF   + L  Y  +  I+    + +      V+   + S  
Sbjct: 65  HPFGHGKYENVSGFVEAILIF-FAALLIIYEALKRIITGAYVENLGMGIVVM---LFSAL 120

Query: 226 ATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYT 285
              +V+    +   +E +++L    M          LL D     GV   A+ + + ++T
Sbjct: 121 INSVVSFYLFKVAKKEDSIALKADAMH---------LLTDVFTSLGV---AAGLVVIRFT 168

Query: 286 GNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHD 345
           G  + D + +I V  ++   +  +    +  L   S+P E+L EI  +++ +  I + H 
Sbjct: 169 GINILDPVIAIFVAFLIIKASVDLTKEALKDLTDTSLPEEELKEIEEIIKSNPEITSFHK 228

Query: 346 VKGIDIGSNLIRYKAEVDFDGRA-LTRSYLEKHDLN 380
           ++    G      K E+D   R     + +E H+L+
Sbjct: 229 LRTRKSGQ-----KREIDVHLRVRRDANIVEAHELS 259


>UniRef50_A7CAR0 Cluster: Cation diffusion facilitator family
           transporter; n=4; Ralstonia|Rep: Cation diffusion
           facilitator family transporter - Ralstonia pickettii 12D
          Length = 390

 Score = 57.2 bits (132), Expect = 8e-07
 Identities = 65/264 (24%), Positives = 116/264 (43%), Gaps = 27/264 (10%)

Query: 106 RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD 165
           R  L + G+N      ++ A  ++ S  L ++ +H+L+D +   I+      S +  D D
Sbjct: 28  RSTLVSAGVNCVLSAGQIAAGLWSHSQGLVADGLHTLSDLIADGIVFIANRNSHKGPDED 87

Query: 166 HPYGYTNMRYVSSLISGVGIFCVGSGLS-FYHGVTGILDPQPLHDFYWAYFVLGGAVVSE 224
           H YG+   RY ++   G+G+  VG+G    +  V  +  PQ             G     
Sbjct: 88  HQYGHA--RYENAASLGLGLLLVGAGAGMIWAAVESLRSPQ-------------GPAPVH 132

Query: 225 GATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQY 284
           G  L+VAL A+   A+E    L+ Y++  +   +N  +L   A  A     +S +A    
Sbjct: 133 GPALVVALIAL--AAKE---GLFRYMLAMA-KRINSRMLIANAWHARSDAVSSLVAAVGV 186

Query: 285 TGNPLP----DALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMI 340
            GN +     D + + +VG ++G V        +  L+ R++P  Q++ I + LE    +
Sbjct: 187 AGNLMGYHWLDPVAACVVGLMIGRVGVRFGWEALNDLMDRALPPAQVEAIRASLEATPGV 246

Query: 341 RAIHDVKGIDIGSN-LIRYKAEVD 363
             +HD++    G   L+    EVD
Sbjct: 247 MNVHDLRTRVTGDQALVDAHIEVD 270


>UniRef50_A1AWZ0 Cluster: Cation diffusion facilitator family
           transporter; n=2; sulfur-oxidizing symbionts|Rep: Cation
           diffusion facilitator family transporter - Ruthia
           magnifica subsp. Calyptogena magnifica
          Length = 384

 Score = 57.2 bits (132), Expect = 8e-07
 Identities = 57/258 (22%), Positives = 120/258 (46%), Gaps = 29/258 (11%)

Query: 104 SGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMAD 163
           S +V L    ++    +FK+ A F   S +L ++ IHS +D ++  ++ Y    S   AD
Sbjct: 15  SQKVTLMGAVVDLLLAVFKIIAGFIGNSGALIADGIHSFSDLLSDGLILYATKHSALDAD 74

Query: 164 PDHPYGYTNMRYVSSLISGVGIFCVGSGLS-FYHGVTGILDPQPLHDFYWAYFVLGGAVV 222
            +HPYG+     V++L  G+ I     GLS  ++ +T + +P  L               
Sbjct: 75  EEHPYGHKRFETVATL--GLAIILAIIGLSVIFNAMTRLANPYSL--------------- 117

Query: 223 SEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLED-----TAAVAGVIVAAS 277
              ++L++++  +   ++EA   LY Y ++ ++   + +L  +     + A++ ++V   
Sbjct: 118 -SHSSLLLSIGTLSIFSKEA---LYWYTLKVANTYKSDLLKANAWHHRSDALSSIVVLIG 173

Query: 278 CMAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERD 337
                   G P  D++ +I+VG ++  +A  + L     LV  SI  +Q+ ++   L + 
Sbjct: 174 --IFGSLNGYPYLDSIAAIVVGLMVIYIAWKLGLDATKELVDTSIDAQQVTQLKHALGKI 231

Query: 338 FMIRAIHDVKGIDIGSNL 355
             + ++H ++   IG  +
Sbjct: 232 SGVNSVHSLRTRKIGHTI 249


>UniRef50_A1SH46 Cluster: Cation diffusion facilitator family
           transporter; n=1; Nocardioides sp. JS614|Rep: Cation
           diffusion facilitator family transporter - Nocardioides
           sp. (strain BAA-499 / JS614)
          Length = 313

 Score = 56.8 bits (131), Expect = 1e-06
 Identities = 51/227 (22%), Positives = 98/227 (43%), Gaps = 16/227 (7%)

Query: 106 RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD 165
           R +  ++G+       KL A+  TG  +LF+E +H+L+D      L   ++ + ++ D +
Sbjct: 25  RALKISVGVYLGILAMKLAAYLVTGVMALFAEAMHTLSDLFVSGFLLVAVYVAGRVPDRE 84

Query: 166 HPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEG 225
           H +G+     V++L++   +F   +    Y      L      ++   +  +   +VS  
Sbjct: 85  HRFGHGRAENVAALVAAT-LFISFTSYQLYIEAVPALFSADEAEYSNLWLAIAVLLVSAL 143

Query: 226 ATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYT 285
           A  +  +  +R+  R A         R+        L+ D   +A  +V    +A+    
Sbjct: 144 AAAVPLIGLLRRHERGA-------AARAQTQE----LINDQLGLAAALVGTVLLAV---- 188

Query: 286 GNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINS 332
           G PL D + +I+V T++   A  I   N   L+GRS   E LD + +
Sbjct: 189 GVPLADPIAAIVVATVIAYEAVKIFRINYSLLLGRSPDPEYLDRLQA 235


>UniRef50_A1K3F1 Cluster: Putative cobalt-zinc-cadmium resistance
           protein; n=1; Azoarcus sp. BH72|Rep: Putative
           cobalt-zinc-cadmium resistance protein - Azoarcus sp.
           (strain BH72)
          Length = 404

 Score = 56.8 bits (131), Expect = 1e-06
 Identities = 56/248 (22%), Positives = 108/248 (43%), Gaps = 28/248 (11%)

Query: 106 RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD 165
           R  L AI  N    + ++     + + SL ++ +H+L+D V  +++ +   +  + AD +
Sbjct: 37  RAALAAICTNALLVVSQVVIGLLSNAFSLVADAMHTLSDLVTDILVLFAGRRGAEPADHN 96

Query: 166 HPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGV-TGILDPQP-LHDFYWAYFVLGGAVVS 223
           HPYG+  +    SL+ GV +  VG+G  +  G+    +D  P LH             V+
Sbjct: 97  HPYGHGRIETFVSLLLGVALGAVGAGFLWASGMRLQHMDAAPTLHP------------VA 144

Query: 224 EGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAI-- 281
            G  L   L      A+E    L+ Y + ++   +   LLE  A  A    A+S +    
Sbjct: 145 LGMALFTLL------AKEV---LFRYTLAAA-RRLQAPLLEANAWHARSDAASSLVVAVG 194

Query: 282 --SQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFM 339
                 G P  + L + LVG ++      ++   V  L+  ++P E++  + + +     
Sbjct: 195 IGGSLAGFPFLEPLAAALVGFLIAHTGWRVVAGAVRELIDTALPDEEVARLRTTIRATPG 254

Query: 340 IRAIHDVK 347
           +  +HD++
Sbjct: 255 VAGLHDLR 262


>UniRef50_Q97LF5 Cluster: C-terminal region cation efflux system
           protein CZCD; n=13; Clostridium|Rep: C-terminal region
           cation efflux system protein CZCD - Clostridium
           acetobutylicum
          Length = 403

 Score = 56.4 bits (130), Expect = 1e-06
 Identities = 65/321 (20%), Positives = 144/321 (44%), Gaps = 32/321 (9%)

Query: 114 INGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNM 173
           +N   F+ +L    +  S ++ ++  H+LAD    +I   G   S + AD +HP+G+  +
Sbjct: 46  VNLILFVIELSIGIFINSIAVIADAFHNLADVSASVITLIGFKLSNKPADKEHPFGHGRV 105

Query: 174 RYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALS 233
            Y+S+L+    I  VG           IL P+P+     ++ ++   ++     L + LS
Sbjct: 106 EYLSALLVSAIILLVGVEF-IKTSFLRILSPEPV-----SFNLISFIIMLIAIPLKLWLS 159

Query: 234 AIRKG-AREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDA 292
              K   ++ N S    +  S   ++N V +  +  ++ ++ A S ++I  Y G      
Sbjct: 160 LFNKNIGKKINSSA---LKASGADALNDVYILSSVILSLLVSAFSTISIDGYVG------ 210

Query: 293 LGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHD--VKGID 350
              +L+G ++   A  ++   +  L+G++     +  I  +  +  +I  +HD  +    
Sbjct: 211 ---VLIGALIIWSAVNLMKDTIDPLLGQAPDPNLVKSIKKMALKCDVILGVHDLIIHNYG 267

Query: 351 IGSNLIRYKAEVDFDGRALTRSYLEKHDLNALLEDMKKIDTIDDVETFLLKHGENIV--D 408
            G  +I + AEV ++   +T        L++ +++ +K    ++++ F++ H + ++   
Sbjct: 268 PGRTMISFHAEVPYNIPIMT--------LHSKIDETEK-RISEELDIFVVIHMDPLLIGS 318

Query: 409 MLGGEIDRIELKLRKKFPQIR 429
               E  R   K+ K FP ++
Sbjct: 319 PEVSEAKRYVSKILKDFPSVQ 339


>UniRef50_A7GZD1 Cluster: MMT1 protein; n=1; Campylobacter curvus
           525.92|Rep: MMT1 protein - Campylobacter curvus 525.92
          Length = 372

 Score = 56.4 bits (130), Expect = 1e-06
 Identities = 55/242 (22%), Positives = 111/242 (45%), Gaps = 19/242 (7%)

Query: 106 RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD 165
           +  L  I  N C    K+C    +GS ++ ++ I++L+D  + +I  +G   + +M D D
Sbjct: 18  KTALIGIITNVCLAATKICIALVSGSVAIITDAINNLSDASSCVITIFGSKLAAKMPDED 77

Query: 166 HPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEG 225
           HPYGY  + Y+  L+  + +  +G        +  I+   P+   + A  +L   ++   
Sbjct: 78  HPYGYGRVEYIGGLVVSIVVLMLGFDF-LKTSICNII--SPVQTKFTAPLLL---ILFIA 131

Query: 226 ATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYT 285
             +  AL A  +   +   S+       S  +V    L D A ++ VI+ ++  A+S + 
Sbjct: 132 IFVKFALGAHYRKVGKNTKSI-------SLKAVGTEALGD-AIISCVILFSA--ALSYFW 181

Query: 286 GNPLPDALGSIL-VGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIH 344
           G  +    G++  +  I+ GV   +I      ++G  +  E +DEI + + R  ++R  +
Sbjct: 182 GVQIDGYAGALASLFIIINGV--LLIKETFDKIIGGRVEKEVVDEIYAAVNRCEIVRGSY 239

Query: 345 DV 346
           D+
Sbjct: 240 DL 241


>UniRef50_Q0W2J0 Cluster: Predicted cation efflux protein; n=3;
           Euryarchaeota|Rep: Predicted cation efflux protein -
           Uncultured methanogenic archaeon RC-I
          Length = 315

 Score = 56.4 bits (130), Expect = 1e-06
 Identities = 59/221 (26%), Positives = 102/221 (46%), Gaps = 26/221 (11%)

Query: 120 LFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSL 179
           + KL      GS S+ SE IHS  D V  +I  + +  S +  D +H +G+  +  +S  
Sbjct: 28  ILKLIVGVMIGSVSVISEAIHSGIDLVAAVIAYFSVRTSSKPPDHEHAFGHGKLENISGT 87

Query: 180 ISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGA 239
           I  + IF V +G   Y     IL    L D            VS G  +M+ LSAI    
Sbjct: 88  IEALLIF-VAAGFIIYEAYEKILHGVVLED------------VSLGIAVML-LSAI---- 129

Query: 240 REANMSLYEYVMRSSDPSVNVVLLED-----TAAVAGVIVAASCMAISQYTGNPLPDALG 294
              N+ + + +M+++  + ++ L  D     T  +  + + A  +AI + TG  + D + 
Sbjct: 130 --VNLYVSQRLMKTAKRTESIALEADAWHLRTDVLTSLGIFAGLVAI-KLTGITILDPIF 186

Query: 295 SILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLE 335
           +ILV   +   A  +I+ +V  L+   +P E+ +EI  ++E
Sbjct: 187 AILVAVFILKAAVELIVRSVKDLMDVKLPEEEENEICQIIE 227


>UniRef50_Q837I0 Cluster: Cation efflux family protein; n=1;
           Enterococcus faecalis|Rep: Cation efflux family protein
           - Enterococcus faecalis (Streptococcus faecalis)
          Length = 389

 Score = 56.0 bits (129), Expect = 2e-06
 Identities = 61/259 (23%), Positives = 115/259 (44%), Gaps = 21/259 (8%)

Query: 112 IGINGCNFLF--KLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYG 169
           IG+    FLF  K      +GS S+ ++ I+SL+DT++ ++   G + + + AD +HPYG
Sbjct: 31  IGLVSNLFLFVSKFMIGLLSGSVSIMADAINSLSDTISSVLTLVGFYIAGKPADKEHPYG 90

Query: 170 YTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLM 229
           +    Y+S ++  + I  +G        V  IL P+ +      + VL    +S G  + 
Sbjct: 91  HERFEYISGMLVSLVITFIGFEF-LTTSVDRILHPESIKVTPILFAVL---ALSIGIKIW 146

Query: 230 VALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPL 289
             L   +  A+  + +L    + S+  S N     D      V+++A    I   TG  +
Sbjct: 147 QGLFYKKVSAKIDSQAL----VASAKDSFN-----DVYTTLAVLISA---FIEGVTGLRI 194

Query: 290 PDALGSILVGTIL-GGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDVKG 348
              +G ++   I+  G+   +I   +  L+G      ++DE+ +VL +   I   HD+  
Sbjct: 195 DGYIGFLIAAYIIYSGLQ--LIREFINELMGMRPSQTEIDEMKNVLSKMETIVGYHDLLI 252

Query: 349 IDIGSNLIRYKAEVDFDGR 367
            + G +       ++ D R
Sbjct: 253 HNYGPSQTFASVHIEIDDR 271


>UniRef50_Q6A6E4 Cluster: Predicted Co/Zn/Cd cation transporter;
           n=1; Propionibacterium acnes|Rep: Predicted Co/Zn/Cd
           cation transporter - Propionibacterium acnes
          Length = 311

 Score = 56.0 bits (129), Expect = 2e-06
 Identities = 38/127 (29%), Positives = 59/127 (46%), Gaps = 4/127 (3%)

Query: 120 LFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSL 179
           L K  AW  TGS  L S+   SL + V  +I    +  S++  D +H +G++   Y S+ 
Sbjct: 36  LLKTLAWHITGSVGLLSDAAESLVNLVAAIIALVALKVSIRPPDMNHQFGHSKAEYFSAG 95

Query: 180 ISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGA 239
             G+ IF + + +  Y  V   L P+P+ D      V   A V  GA   + LS    G 
Sbjct: 96  AEGMMIF-IAAAVIVYSAVERFLYPRPIADAGVGLLVSVLASVINGAVAWILLS---NGH 151

Query: 240 REANMSL 246
           +  +M+L
Sbjct: 152 KRRSMTL 158


>UniRef50_Q6NE50 Cluster: Magnetosome protein MamB; n=5;
           Magnetospirillum|Rep: Magnetosome protein MamB -
           Magnetospirillum gryphiswaldense
          Length = 297

 Score = 56.0 bits (129), Expect = 2e-06
 Identities = 57/250 (22%), Positives = 109/250 (43%), Gaps = 19/250 (7%)

Query: 107 VVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDH 166
           VV  A   + C  LFK      +GS +L ++ +HS AD V   +    +  S + AD  +
Sbjct: 13  VVWWAFTADICMTLFKGILGLMSGSVALVADSLHSGADVVASGVTQLSLKISNKPADERY 72

Query: 167 PYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGA 226
           P+GY N++Y+SS I G  +  +G+    Y  V  ++        Y A  +        GA
Sbjct: 73  PFGYGNIQYISSAIVG-SLLLIGASFLMYGSVVKLIS-----GTYEAPSIFAAL----GA 122

Query: 227 TLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVL-LEDTAAVAGVIVAASCMAISQYT 285
           ++ V ++ +        M  Y+  + + + S  ++    D  + A    A     I+   
Sbjct: 123 SVTVIVNEL--------MYRYQICVGNENNSPAIIANAWDNRSDAISSAAVMVGVIASVI 174

Query: 286 GNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHD 345
           G P+ D + +I V  ++G +   +I   V  L+  S+  E L     +     ++ +I+ 
Sbjct: 175 GFPIADTIAAIGVSALVGHIGLELIGKAVHGLMDSSVDTELLQTAWQIATDTPLVHSIYF 234

Query: 346 VKGIDIGSNL 355
           ++G  +G ++
Sbjct: 235 LRGRHVGEDV 244


>UniRef50_A1WC43 Cluster: Cation diffusion facilitator family
           transporter; n=8; Burkholderiales|Rep: Cation diffusion
           facilitator family transporter - Acidovorax sp. (strain
           JS42)
          Length = 319

 Score = 55.6 bits (128), Expect = 2e-06
 Identities = 34/137 (24%), Positives = 64/137 (46%), Gaps = 6/137 (4%)

Query: 111 AIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGY 170
           ++G+     + K  AW+ +GS  L S+ + S  +    +     +  + + AD DHPYG+
Sbjct: 24  SVGVALLTIVLKTLAWWVSGSVGLLSDALESFVNLAGAMFALAMVTIARRPADEDHPYGH 83

Query: 171 TNMRYVSSLISGVGIFCVGSGLS-FYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLM 229
               Y SS     GI  VG+ ++  +  V  ++ PQPL    W    +G +++S     +
Sbjct: 84  HKAEYFSSGFE--GILIVGASIAILWAAVLRLMHPQPLEQLGWG---MGLSLLSTACNGL 138

Query: 230 VALSAIRKGAREANMSL 246
           +A   +R      +++L
Sbjct: 139 LAWGMLRAAQVHRSLAL 155


>UniRef50_A0KQ43 Cluster: Cation efflux family protein; n=2;
           Aeromonas|Rep: Cation efflux family protein - Aeromonas
           hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB
           9240)
          Length = 292

 Score = 55.6 bits (128), Expect = 2e-06
 Identities = 37/127 (29%), Positives = 58/127 (45%), Gaps = 2/127 (1%)

Query: 102 TRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQM 161
           TR  R  L ++  N    + K+ A   +GS S+ SE IHS  D V  LI    + KS   
Sbjct: 2   TRKTRAALVSVCSNITLIIMKIFAGILSGSVSIISEAIHSAMDLVAALIALVAVRKSDIP 61

Query: 162 ADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFV-LGGA 220
            D  HPYG+  +  VS +I  + +  + +G   +  V  ++ P  +        V L  A
Sbjct: 62  PDQRHPYGHDKIENVSGVIEAL-LILLAAGWIIFEAVGKLITPTQIEGVGLGVLVMLFSA 120

Query: 221 VVSEGAT 227
           +V+ G +
Sbjct: 121 LVNSGVS 127


>UniRef50_Q98HP4 Cluster: Mlr2775 protein; n=12; Bacteria|Rep:
           Mlr2775 protein - Rhizobium loti (Mesorhizobium loti)
          Length = 308

 Score = 55.2 bits (127), Expect = 3e-06
 Identities = 24/83 (28%), Positives = 44/83 (53%)

Query: 101 KTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQ 160
           K +   +   +I +       KL AW+ TGS +L+S+ + S+ + +  +   + I  S +
Sbjct: 10  KRKVANLAFWSIAVAFVVLALKLVAWYITGSVALYSDALESIVNVIASVAAFWAIQVSYK 69

Query: 161 MADPDHPYGYTNMRYVSSLISGV 183
            AD DHP+G+    Y S+++ GV
Sbjct: 70  PADQDHPFGHHKAEYFSAVLEGV 92


>UniRef50_A5EV87 Cluster: Cation efflux family protein; n=1;
           Dichelobacter nodosus VCS1703A|Rep: Cation efflux family
           protein - Dichelobacter nodosus (strain VCS1703A)
          Length = 299

 Score = 55.2 bits (127), Expect = 3e-06
 Identities = 62/243 (25%), Positives = 109/243 (44%), Gaps = 32/243 (13%)

Query: 100 LKTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSV 159
           LK  S   V  A+ +     L KL AW+ +GS SL +  + S  D +  +I  + +  ++
Sbjct: 8   LKRASAASVCVAVTL----MLLKLLAWWLSGSVSLLASLMDSATDILASMINLFAVRLAM 63

Query: 160 QMADPDHPYGYTNMRYVSSLISGVGIFCVGSG-LSFYHGVTGILDPQPLHDFYWAYFVLG 218
             AD +H YG+     +S+L     +F  GS      + +  +  PQPL           
Sbjct: 64  CRADNNHHYGHGKAESLSAL--SQAMFITGSSFFLIINALPRLFAPQPL----------- 110

Query: 219 GAVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSD-PSV---NVVLLEDTAAVAGVIV 274
                   T+ + +  I  GA  A +    +V++  D PSV   ++  L DT    GV++
Sbjct: 111 -----SHNTIGIVVMLISLGATLALVRYQHFVLKQVDSPSVHADSLHYLSDTLTGMGVLL 165

Query: 275 AASCMAISQYTGNPLPDALGSILVGT-ILGGVASFIILSNVGALVGRSIPHEQLDEINSV 333
           A   + ++      + D + +IL+G  +L GV   I+   V AL+  ++P  ++D I + 
Sbjct: 166 A---LVLNSAFNIAIADPILAILIGIYMLYGVYQ-IVYDAVSALMDVALPEAEMDMIRAA 221

Query: 334 LER 336
           + R
Sbjct: 222 IAR 224


>UniRef50_A5KR43 Cluster: Putative uncharacterized protein; n=2;
           Ruminococcus|Rep: Putative uncharacterized protein -
           Ruminococcus torques ATCC 27756
          Length = 396

 Score = 54.4 bits (125), Expect = 6e-06
 Identities = 65/278 (23%), Positives = 124/278 (44%), Gaps = 24/278 (8%)

Query: 93  DNVEEVGLKTRSGRVVLTAIGINGCN-FLF--KLCAWFYTGSHSLFSECIHSLADTVNQL 149
           ++VE++ ++T  G V+ + +GI  CN FLF  K        S S+ ++  ++L+D  + +
Sbjct: 14  EDVEKISVRTAYG-VLASIVGIF-CNVFLFAVKFTIGVIAHSVSVMADAFNNLSDAGSSI 71

Query: 150 ILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHD 209
           I   G+  + + AD DHP+G+  + Y+++L+  V    +  G +F     G +    + +
Sbjct: 72  ISFIGVKMAEKPADRDHPFGHGRIEYIAALV--VSFLILEVGFTFLKDSIGKIRTPEMLN 129

Query: 210 FYWAYFVLGGAVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAV 269
           F  A  ++   ++S G  L + L   R G  + N  +   V   S        + D    
Sbjct: 130 FQIASVII--LILSIGVKLWLGLFNKRLG-EKINSKVMMAVFADS--------MGDVITT 178

Query: 270 AGVIVAASCMAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDE 329
              I++   + + + TG  +   +G I V  ++      I    +  L+G +I  +  D+
Sbjct: 179 GATILS---LIVFRITGWNIDGVVG-IGVALVVMWAGVGIAKDTLEPLIGEAIDPQVYDQ 234

Query: 330 INSVLERDFMIRAIHD--VKGIDIGSNLIRYKAEVDFD 365
           I + +E+   I   HD  V     G ++    AEV  D
Sbjct: 235 IKAFVEKYDGIVGTHDLIVHNYGPGRSMASIHAEVPND 272


>UniRef50_A0NZQ3 Cluster: Cation efflux transporter, CDF family
           protein; n=14; Bacteria|Rep: Cation efflux transporter,
           CDF family protein - Stappia aggregata IAM 12614
          Length = 322

 Score = 54.4 bits (125), Expect = 6e-06
 Identities = 56/241 (23%), Positives = 108/241 (44%), Gaps = 21/241 (8%)

Query: 96  EEVGLKTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGI 155
           E + LK R  R+   +I         K+ A+  TGS +L+S+ + ++ +  + +     +
Sbjct: 24  ERMKLKRRL-RIAFLSIVFGVIVLGLKIGAYLLTGSIALYSDALETIVNIASAIATLAAV 82

Query: 156 HKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYF 215
             + + AD +HPYG+  + Y ++++  VG+  V + LS +                W  F
Sbjct: 83  WFAAKPADSNHPYGHDKVEYFAAVL--VGVMIVLAALSIFRAA-------------WLGF 127

Query: 216 VLGGAVVSEGATL-MVALSAIRKGAREANMSLYEYVMRS-SDPSVNVVLLEDTAAVAGVI 273
           V G +     A + M  L+A+  GA    +  Y    RS +  +    L+ D A+  GV+
Sbjct: 128 VNGDSPEYSPAGIGMNLLAAVINGAWARYLMQYGKHARSPALVADGKHLMTDVASSVGVL 187

Query: 274 VAASCMAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSV 333
                + +   TG  + D   ++LVG  +      ++  +VG L+  +  H+ LD+I  +
Sbjct: 188 ---GGVVLVMLTGWKIMDPALAVLVGLTVLWSGWGLVKESVGGLMDEAASHDTLDKIRVL 244

Query: 334 L 334
           +
Sbjct: 245 I 245


>UniRef50_Q83BX5 Cluster: Cation-efflux family protein; n=2;
           Coxiella burnetii|Rep: Cation-efflux family protein -
           Coxiella burnetii
          Length = 378

 Score = 54.0 bits (124), Expect = 7e-06
 Identities = 58/255 (22%), Positives = 112/255 (43%), Gaps = 28/255 (10%)

Query: 107 VVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDH 166
           V L +  +N    LFK+    +  S +L ++ +HSL+D +   ++    H   Q  D +H
Sbjct: 16  VSLVSAAVNTLLALFKIVVGIFGHSQALIADGVHSLSDLLTDGLVVVTGHMGAQSPDKEH 75

Query: 167 PYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGA 226
           PYG+  +  + S+I  V +  V  G++F       L+    H  + A+  L    V    
Sbjct: 76  PYGHRRIETIGSIIIAVILIFVAIGIAF-----DTLE----HLIHHAHLPLPTFPV---- 122

Query: 227 TLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTA------AVAGVIVAASCMA 280
            ++VA+ +I      AN  L+ Y +   +  +N  LL   A      ++  +IV  S   
Sbjct: 123 -IIVAVISI-----IANEGLFRYTLAKGN-QINSDLLRTNAWHNRSDSLVSLIVLIS--V 173

Query: 281 ISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMI 340
           I    G    DA+G+ ++  ++  +   +I +N   L+  ++  + L +I   +     +
Sbjct: 174 IGSRFGITYLDAIGAFIIAVLILRMGIKMIWNNGKELIDTAVDDDTLKKITETISSVPDV 233

Query: 341 RAIHDVKGIDIGSNL 355
            +IH ++    G N+
Sbjct: 234 LSIHQLRTRYHGGNI 248


>UniRef50_A6F284 Cluster: Predicted Co/Zn/Cd cation transporter;
           n=1; Marinobacter algicola DG893|Rep: Predicted Co/Zn/Cd
           cation transporter - Marinobacter algicola DG893
          Length = 388

 Score = 54.0 bits (124), Expect = 7e-06
 Identities = 53/251 (21%), Positives = 109/251 (43%), Gaps = 16/251 (6%)

Query: 106 RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD 165
           RV +  + ++G   L K+ A     S +L  + IHS  D V+ +++   +  S Q  D D
Sbjct: 24  RVTVIGMLLDGVLGLLKVIAGTLFHSQALLVDGIHSFTDVVSDVVVLGVMRVSRQAPDED 83

Query: 166 HPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEG 225
           HPYG+  +  + +++ G  +  VG+ L+ +     +LD   ++   W   VL  A +S  
Sbjct: 84  HPYGHQRIETMGTMVLGSILIAVGAALA-WDNTLRLLDGSTVNIPEWP--VLVAAFIS-- 138

Query: 226 ATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYT 285
              + +   I +  R   +++       SD  +       T A++ V+V  S   I    
Sbjct: 139 ---VASKEWIYRYTRRVGLAI------RSDLIIANAWHSRTDALSSVVVLFS--TIGAML 187

Query: 286 GNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHD 345
           G    D L ++++  I+  +       +V  LV   +  E  + +  +      +R +H+
Sbjct: 188 GYLWLDVLAAVIISGIIIHIGWRFTRDSVKELVDTGLSPEDTETLKHIASETDGVRNVHE 247

Query: 346 VKGIDIGSNLI 356
           ++   +G +++
Sbjct: 248 LRSRRMGHDIL 258


>UniRef50_Q4IXC3 Cluster: Cation efflux protein; n=18;
           Pseudomonadaceae|Rep: Cation efflux protein -
           Azotobacter vinelandii AvOP
          Length = 311

 Score = 53.6 bits (123), Expect = 1e-05
 Identities = 33/90 (36%), Positives = 46/90 (51%), Gaps = 3/90 (3%)

Query: 120 LFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSL 179
           L K  AW+ +GS SL +    SL D    LI    +H S++ AD DH YG+     ++ L
Sbjct: 45  LAKAVAWWLSGSVSLLAGLTDSLLDGAASLINLLAVHYSLRPADDDHRYGHGKAEALAGL 104

Query: 180 ISGVGIFC-VGSGLSFYHGVTGILDPQPLH 208
             G  +F  V + L    G+  +L PQPLH
Sbjct: 105 --GQSVFIGVSALLVGVQGIDRLLHPQPLH 132


>UniRef50_Q3E481 Cluster: Cation efflux protein; n=5; Bacteria|Rep:
           Cation efflux protein - Chloroflexus aurantiacus J-10-fl
          Length = 324

 Score = 53.6 bits (123), Expect = 1e-05
 Identities = 38/141 (26%), Positives = 62/141 (43%), Gaps = 4/141 (2%)

Query: 106 RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD 165
           R    AIG        K  A++ TGS  + ++ + SL +    +I    +  + + AD +
Sbjct: 9   RYAWLAIGAAIATIGLKSGAFWLTGSIGILADALESLVNLAAAVIALIMLTIAARPADEE 68

Query: 166 HPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEG 225
           H YG+    Y +  + GV I     G+  +  +  IL PQPL        V G A +  G
Sbjct: 69  HAYGHGKAEYFAGALEGVFIIIAAMGIG-WTAIQRILSPQPLDHTVAGLLVAGIATLING 127

Query: 226 ATLMVALSAIRKGAREANMSL 246
               VA+  +R G R  +++L
Sbjct: 128 G---VAIVLLRAGRRHDSLTL 145


>UniRef50_Q1LHU8 Cluster: Cation diffusion facilitator family
           transporter; n=3; Proteobacteria|Rep: Cation diffusion
           facilitator family transporter - Ralstonia metallidurans
           (strain CH34 / ATCC 43123 / DSM 2839)
          Length = 337

 Score = 53.2 bits (122), Expect = 1e-05
 Identities = 24/87 (27%), Positives = 45/87 (51%)

Query: 106 RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD 165
           R  + ++ +N    + +       GS +L ++ +HSL+D ++  ++ +  H S + AD D
Sbjct: 47  RSTMVSVYVNIALSIAQAVIGIIAGSQALVADALHSLSDLISDFVVLFAGHHSRKDADTD 106

Query: 166 HPYGYTNMRYVSSLISGVGIFCVGSGL 192
           HPYG+      +SL  G  +  VG G+
Sbjct: 107 HPYGHQRFETAASLAIGALLLAVGVGM 133


>UniRef50_A6PM43 Cluster: Cation diffusion facilitator family
           transporter; n=1; Victivallis vadensis ATCC BAA-548|Rep:
           Cation diffusion facilitator family transporter -
           Victivallis vadensis ATCC BAA-548
          Length = 389

 Score = 53.2 bits (122), Expect = 1e-05
 Identities = 53/240 (22%), Positives = 103/240 (42%), Gaps = 21/240 (8%)

Query: 109 LTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPY 168
           +  +  N   F  K+     +GS ++ ++ +++L+D  + ++   G   + + AD +HP+
Sbjct: 32  MVGVACNVALFAAKMTVGLISGSIAVLADAVNNLSDAGSSVVALIGFRMAAKPADDEHPF 91

Query: 169 GYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATL 228
           G+  + YV+ L+  V I  VG    F      I  P                VVS    L
Sbjct: 92  GHGRLEYVAGLVIAVIIIAVGIDF-FKSAAERIFHPVE-------------TVVSNWGML 137

Query: 229 MVALS-AIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGN 287
            VAL+  ++      N  L + +  +   +     L D    + V+ +A   A+S++T  
Sbjct: 138 AVALAIPVKFWMFLFNRKLGKKIDSTVLQATAFDSLSDILTTSVVLASA---AVSRFTSF 194

Query: 288 PLPDALG-SILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDV 346
           P     G ++ V  ILGG+   ++   V  L+G     + ++E+   +  +  I  +HD+
Sbjct: 195 PADGYAGVAVAVLIILGGIK--VVRDTVNPLLGECPDRQLVEELERKMLENPDICGVHDL 252


>UniRef50_Q65T10 Cluster: MMT1 protein; n=1; Mannheimia
           succiniciproducens MBEL55E|Rep: MMT1 protein -
           Mannheimia succiniciproducens (strain MBEL55E)
          Length = 380

 Score = 52.8 bits (121), Expect = 2e-05
 Identities = 29/120 (24%), Positives = 60/120 (50%), Gaps = 2/120 (1%)

Query: 122 KLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLIS 181
           K+   F+T S ++  + +++L+D+++ L+   G   + +  D  HPYGY  + Y+++++ 
Sbjct: 30  KVTIGFFTNSLAVMLDALNNLSDSLSSLVTIVGTKLATRAPDKKHPYGYGRIEYITAIVI 89

Query: 182 GVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLG-GAVVSEGATLMVALSAIRKGAR 240
           G  IF  G+  +    +  I+ P+  +    A  ++  G VV  G    V  S    G++
Sbjct: 90  GAIIFLAGA-TALKESIAKIITPEETNYNITAIVIISIGIVVKYGLGRFVKNSGEELGSQ 148


>UniRef50_Q11X42 Cluster: Cation efflux system protein; n=8;
           Bacteroidetes|Rep: Cation efflux system protein -
           Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)
          Length = 317

 Score = 52.8 bits (121), Expect = 2e-05
 Identities = 29/103 (28%), Positives = 50/103 (48%), Gaps = 2/103 (1%)

Query: 120 LFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSL 179
           + K  A F+  SH+L ++ I S +D    +++ +GI  S + AD  HPYG+  +  + + 
Sbjct: 51  IIKWLAGFFGNSHALIADAIESTSDIFASMLILFGIKFSHKPADNKHPYGHGRIEPLITF 110

Query: 180 ISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVV 222
           +  VG     S +  Y  +  I  P  L +  W   VL G ++
Sbjct: 111 LV-VGFLISSSVIIAYQSIINIQTPHELPE-AWTLIVLAGIII 151


>UniRef50_A6BDG0 Cluster: Putative uncharacterized protein; n=2;
           Clostridiaceae|Rep: Putative uncharacterized protein -
           Dorea longicatena DSM 13814
          Length = 296

 Score = 52.8 bits (121), Expect = 2e-05
 Identities = 31/96 (32%), Positives = 49/96 (51%), Gaps = 3/96 (3%)

Query: 109 LTAIGINGCNFL--FKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDH 166
           L+ +GI G   L  FKL A     S ++ S+ +HSL+D     I   G+  S + AD +H
Sbjct: 17  LSTVGILGNVILTAFKLLAGIIGHSGAMISDAVHSLSDVFATFIAFLGVKLSKKSADSEH 76

Query: 167 PYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGIL 202
           PYG+  +  V+S++    +   G G+    GV  I+
Sbjct: 77  PYGHDRLECVASMVLAAILLATGIGIGM-SGVKTII 111


>UniRef50_A3VV32 Cluster: Cation efflux family protein; n=1;
           Parvularcula bermudensis HTCC2503|Rep: Cation efflux
           family protein - Parvularcula bermudensis HTCC2503
          Length = 303

 Score = 52.8 bits (121), Expect = 2e-05
 Identities = 61/225 (27%), Positives = 98/225 (43%), Gaps = 27/225 (12%)

Query: 120 LFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSL 179
           + K  AW  TGS ++      SL D +  LI   G+  + Q  D +H +G+     +SSL
Sbjct: 26  ILKAAAWIETGSVAMLGSLADSLLDLLASLIAFLGVRIAAQPPDENHRFGHAKAEAISSL 85

Query: 180 ISGVGIFCVGSGL-SFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKG 238
           +  V I   GS +      +  ++DP PL     A  V+   V S GATL+  L A +  
Sbjct: 86  VQLVMI--TGSAVFVLVESIRALIDPAPLAHANLAIQVM---VASIGATLL--LVAFQTF 138

Query: 239 AREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILV 298
           A   + SL       +  S     L D  A AG+++A             L    G +  
Sbjct: 139 ALSRSTSL-------ATESDRAHYLGDFIANAGILLAVI-----------LTGRFGILWA 180

Query: 299 GTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAI 343
             + G +A+  +  +V ++  R++P + +DE  S  ER  ++R I
Sbjct: 181 DGVAGVLAAGFLFWSVISIARRALP-QLMDEEVSAAERAKILRII 224


>UniRef50_A1BEH5 Cluster: Cation diffusion facilitator family
           transporter; n=4; Chlorobium|Rep: Cation diffusion
           facilitator family transporter - Chlorobium
           phaeobacteroides (strain DSM 266)
          Length = 338

 Score = 52.8 bits (121), Expect = 2e-05
 Identities = 50/235 (21%), Positives = 103/235 (43%), Gaps = 19/235 (8%)

Query: 101 KTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQ 160
           K+ + + ++ A G+     + K  AW+ T S ++ ++ + S+ +  +  I  Y ++ S +
Sbjct: 13  KSYNFQKIIAATGV--LLLIIKFGAWYLTHSVAILTDALESIVNVTSGFIGLYSLYISAK 70

Query: 161 MADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGA 220
             D  HPYG+  + ++S+ I G  +  V   L     V   + P  +    +   ++   
Sbjct: 71  PRDSSHPYGHGKVEFISAAIEGT-LISVAGLLIINAAVDNFIHPGAVGQLDYGILLVS-- 127

Query: 221 VVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMA 280
            ++      V   A+R G R  +++L          +    L  DT +  G+I   + +A
Sbjct: 128 -MTAAINWFVGSLAVRNGKRNGSLALI---------ASGRHLQSDTWSTIGIIAGLALLA 177

Query: 281 ISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLE 335
           ++  T   L  A+  I  G IL  V  + IL +  + +      E L++I ++L+
Sbjct: 178 LTGLTW--LDSAVALIFAGVIL--VTGYKILRSSLSGIMDEADTELLEKIVALLQ 228


>UniRef50_Q6LZI4 Cluster: Cation efflux protein; n=11; cellular
           organisms|Rep: Cation efflux protein - Methanococcus
           maripaludis
          Length = 291

 Score = 52.8 bits (121), Expect = 2e-05
 Identities = 60/265 (22%), Positives = 114/265 (43%), Gaps = 29/265 (10%)

Query: 120 LFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSL 179
           + K+ A  +  S +L ++ +HS +D ++ +++  G+  S + AD  HPYG+  +    + 
Sbjct: 26  ILKILAGVFGKSSALIADGMHSFSDILSTVVVMLGLKLSEKPADESHPYGHERIEPALTK 85

Query: 180 ISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGA 239
           I  V I  V + + FY G+T I+               G   +    T++ AL +I    
Sbjct: 86  ILAV-ILLVTALMIFYCGLTTIIG--------------GNYQIPGNITIIAALISI---- 126

Query: 240 REANMSLYEYVMRSSDPSVNVVLLEDT---AAVAGVIVAASCMAISQYTGNPLPDALGSI 296
                 +Y+Y  + ++   +  LL D     + A   V      +    G P+ D + SI
Sbjct: 127 -FTKEWMYKYTKKGAEQIESSALLADAWHHRSDAFSSVGTLIGVVGAKLGYPILDPIASI 185

Query: 297 LVGTILGGVASFIILSNVGALVGRSIPHEQLDEINS-VLERDFMIRAIHDVKGIDIGSNL 355
           ++   +  +A  I    +  L+ R+   + ++EI   +L  D ++    DV    I SN 
Sbjct: 186 VISLFIAKMAFEIYFKALNQLLDRAADSKTIEEIKKIILSVDGVLEI--DVLKTRIHSNK 243

Query: 356 IRYKAEVDFDGRALTRSYLEKHDLN 380
           I    E+  D      S +E H+++
Sbjct: 244 IYVDVEISVD---KDLSLIEAHNIS 265


>UniRef50_O30282 Cluster: Conserved hypothetical transmembrane
           protein; n=1; Archaeoglobus fulgidus|Rep: Conserved
           hypothetical transmembrane protein - Archaeoglobus
           fulgidus
          Length = 384

 Score = 52.8 bits (121), Expect = 2e-05
 Identities = 47/216 (21%), Positives = 98/216 (45%), Gaps = 20/216 (9%)

Query: 122 KLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLIS 181
           K+ A  +  S +L ++ +HSL D +  +++  GI  + + AD  HPYG+     ++ +  
Sbjct: 22  KVAAGIFANSTALIADGVHSLVDVLGSVLVWLGIKVAERPADASHPYGHFKAESLAEMAV 81

Query: 182 GVGIFCVGSGLSFYHGVTGILDPQ-PLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGAR 240
           G+ I  + S L  +  ++ +++   P  + Y     +  AV +E    ++A   IR G +
Sbjct: 82  GL-IIILSSLLIMHEAISSVINASVPTFELYAVAVAMLSAVANE----LLARYKIRVGLK 136

Query: 241 EANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGT 300
             + SL   +       V+V  L   A V G            Y G    D++ +I +  
Sbjct: 137 TRSTSL---IAEGKHSRVDV--LSSLAVVVGFFFV--------YFGYWWADSVVAIAISV 183

Query: 301 ILGGVASFIILSNVGALVGRSIPHEQLDEINSVLER 336
           ++  +   ++ +++  L+ R +  E   ++ SV+E+
Sbjct: 184 VILQIGGSVLKNSIDVLMDR-VDEELALKVRSVIEK 218


>UniRef50_Q479I8 Cluster: Cation efflux protein; n=1; Dechloromonas
           aromatica RCB|Rep: Cation efflux protein - Dechloromonas
           aromatica (strain RCB)
          Length = 389

 Score = 52.4 bits (120), Expect = 2e-05
 Identities = 46/240 (19%), Positives = 105/240 (43%), Gaps = 22/240 (9%)

Query: 111 AIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGY 170
           ++ +N    + +L   +   S SL +  +HS +D ++  ++ Y   +S   AD  HPYG+
Sbjct: 26  SVAVNLVMTVIQLIVGWLAHSQSLVAHGLHSFSDLLSDFLVIYASRQSAHPADEAHPYGH 85

Query: 171 TNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMV 230
             M   ++L+ G  +  +G G+ +  G+      +  H        +      E + L V
Sbjct: 86  ARMETAATLVLGASLTLIGGGILWESGM------RLQH--------IEALPTVELSALWV 131

Query: 231 ALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAI---SQYTGN 287
           A++ +   ++EA   LY Y++R ++   + +L+ +         +A  + +       G 
Sbjct: 132 AIATV--VSKEA---LYRYLIRVAERLRSQLLIANALHTRADAASALVVVVGIGGALLGW 186

Query: 288 PLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDVK 347
              D L + L+G ++  + + +    +  L+   +   Q++ I + L     +R +H ++
Sbjct: 187 SFLDLLAAALMGFMILRMGAGLAWGAIKELIDTGLDESQVEAIRATLRETPGVRGLHQLR 246


>UniRef50_Q83PD6 Cluster: Cation-efflux pump fieF; n=70;
           Gammaproteobacteria|Rep: Cation-efflux pump fieF -
           Shigella flexneri
          Length = 300

 Score = 52.4 bits (120), Expect = 2e-05
 Identities = 31/105 (29%), Positives = 51/105 (48%), Gaps = 3/105 (2%)

Query: 106 RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD 165
           R  + A  +     L K+ AW+YTGS S+ +  + SL D    L     +  S+Q AD +
Sbjct: 11  RAAIAATAMASLLLLIKIFAWWYTGSVSILAALVDSLVDIGASLTNLLVVRYSLQPADDN 70

Query: 166 HPYGYTNMRYVSSLISGVGIFCVGSGL-SFYHGVTGILDPQPLHD 209
           H +G+     +++L     +F  GS L  F  G+  ++ P P+ D
Sbjct: 71  HSFGHGKAESLAALAQ--SMFISGSALFLFLTGIQHLVSPTPMTD 113


>UniRef50_Q9A2C4 Cluster: Cation efflux family protein; n=4;
           Alphaproteobacteria|Rep: Cation efflux family protein -
           Caulobacter crescentus (Caulobacter vibrioides)
          Length = 309

 Score = 52.0 bits (119), Expect = 3e-05
 Identities = 56/250 (22%), Positives = 104/250 (41%), Gaps = 20/250 (8%)

Query: 100 LKTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSV 159
           ++  + RV + ++       + K  AW  +GS ++ +    S  D V  LI  Y +  + 
Sbjct: 10  IRKATQRVAMLSVATAAILIVVKAIAWQASGSVAILASLSDSALDLVASLITVYAVRYAA 69

Query: 160 QMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGG 219
           +  D +H +G+      SSL+ G  +F  G+ L     +   L PQP+      + + G 
Sbjct: 70  EPPDAEHRFGHGKAEAFSSLMQGGLVFASGA-LVGREAINAWLHPQPVE-----HGLAGV 123

Query: 220 AVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCM 279
           AV++    L +AL   +    +A+ S+    +          L  +  A+ GV  AA   
Sbjct: 124 AVMAISIVLTLALITAQTRVVKASGSI---AISGDRAHYAADLASNAVALVGVGAAA--- 177

Query: 280 AISQYTGNPLPDALGSILVG--TILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERD 337
               + G P  DA   ++V    I G V  F   S+   L+   +P     +I +++  D
Sbjct: 178 ----WLGLPRVDAAAGLIVALWLIWGAVGVFREASH--QLMDHELPDADRTKIVALVTAD 231

Query: 338 FMIRAIHDVK 347
             +  +H ++
Sbjct: 232 PNVLGVHQLR 241


>UniRef50_Q18YB5 Cluster: Cation diffusion facilitator family
           transporter; n=4; Clostridiales|Rep: Cation diffusion
           facilitator family transporter - Desulfitobacterium
           hafniense (strain DCB-2)
          Length = 388

 Score = 52.0 bits (119), Expect = 3e-05
 Identities = 61/263 (23%), Positives = 112/263 (42%), Gaps = 22/263 (8%)

Query: 93  DNVEEVGLKTRSGRVVLTAIGINGCN---FLFKLCAWFYTGSHSLFSECIHSLADTVNQL 149
           +N+ +  ++ + G V+  A+GI  CN   F+ KL    +  S ++ S+  ++L+D  + +
Sbjct: 14  ENISDKRVREQYG-VLAGALGII-CNLILFILKLLLGLFMNSIAVISDAFNNLSDCGSSV 71

Query: 150 ILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHD 209
           I       S +  D +HP+G+  + Y+SSL+    IF VG  L   +  T IL P+ +  
Sbjct: 72  IAIIAAKMSNRPPDIEHPFGHGRIEYISSLVVSFIIFMVGIEL-LKNSFTKILHPEEVL- 129

Query: 210 FYWAYFVLGGAVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAV 269
           F W   V+   ++      +   S  R      N  + +    ++  S+N  L      +
Sbjct: 130 FSWISLVI---LLFSVVLKIWMFSYNRYIGHTINSGINK---ATAYDSLNDALATSAVIL 183

Query: 270 AGVIVAASCMAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDE 329
           + +I  A  +AI  Y G         +L+   +      +    V  L+G S   E  ++
Sbjct: 184 STLIGHAFDLAIDGYVG---------LLISLFILYTGYNVAKETVNILLGSSPNPELCNQ 234

Query: 330 INSVLERDFMIRAIHDVKGIDIG 352
           +   +     I   HD+K  D G
Sbjct: 235 VKDFVNEGMYIIGTHDLKVHDYG 257


>UniRef50_Q0BW07 Cluster: Cobalt-zinc-cadmium resistance protein
           czcD; n=1; Granulibacter bethesdensis CGDNIH1|Rep:
           Cobalt-zinc-cadmium resistance protein czcD -
           Granulobacter bethesdensis (strain ATCC BAA-1260 /
           CGDNIH1)
          Length = 306

 Score = 52.0 bits (119), Expect = 3e-05
 Identities = 61/240 (25%), Positives = 105/240 (43%), Gaps = 24/240 (10%)

Query: 101 KTRSGRVVLTAIG--INGCNFL-FKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHK 157
           +T S R  + A G  + G   L  KL AW  T S +LFS+ + S+ +    L+    +  
Sbjct: 8   ETSSRRTKMVASGTIVIGIVVLGLKLLAWRMTNSTALFSDAMESIVNVAASLMAFAALVY 67

Query: 158 SVQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVL 217
           + + AD +HPYG+  + + +++  G  +  V +   F      I  P+ L D  ++   L
Sbjct: 68  AQRPADDNHPYGHGKIEFFAAVGEG-ALILVAAMAIFQEAWHAIQQPRILLDAPFSGIAL 126

Query: 218 GGAVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNV---VLLEDTAAVAGVIV 274
            GA     AT++  L   R         L +   R+  PS+      LL D  + +GV+ 
Sbjct: 127 NGA-----ATMLNGLWGWR---------LMKTARRTHSPSLKADASHLLNDVVSSSGVVA 172

Query: 275 AASCMAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVL 334
               +  +   G P+ D L + LV   +      +I  +VG L+  +   + L+ I SV+
Sbjct: 173 G---LLGAWLVGQPILDPLLAGLVAVYILWSGFRLIRESVGGLMDEAPTPDVLERIRSVV 229


>UniRef50_A3CXT0 Cluster: Cation diffusion facilitator family
           transporter; n=2; Methanomicrobia|Rep: Cation diffusion
           facilitator family transporter - Methanoculleus
           marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
          Length = 416

 Score = 52.0 bits (119), Expect = 3e-05
 Identities = 66/288 (22%), Positives = 124/288 (43%), Gaps = 26/288 (9%)

Query: 106 RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD 165
           RV   ++ +N    + KL    YTGS +L ++ IHS  D V  L L  G++ S +    D
Sbjct: 21  RVAFLSLAVNAGLVVAKLLLSVYTGSLALRADGIHSFVDVVASLALIVGVYLSSRKR-RD 79

Query: 166 HPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEG 225
            PYG   +  V ++   + IF     ++    VTG    QP    Y  + +L  A     
Sbjct: 80  FPYGLYKVENVVAVAIALLIFFTAFEIA-AEAVTGDAAAQP----YSGWVLLAVAAFIPV 134

Query: 226 ATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYT 285
             ++        G  E N+       + + PS+     +    V    V    + + Q+ 
Sbjct: 135 PYIL--------GTYEVNVG-----RKYNSPSLIADGRQHRVDVLSSSVVFFAL-LGQFF 180

Query: 286 GNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHD 345
           G PL D + +++V   +      I+  ++  L+  S+ ++ L+EI S++  D  +  I  
Sbjct: 181 GIPL-DRIAAVVVAVFIVRAGWGILKDSMRTLLDASVDYDTLNEIRSIILSDPKVSGIKS 239

Query: 346 VKGIDIGSNL----IRYKAEVDFDGRALTRSYLEKHDLNALLEDMKKI 389
           + G + G  +    +   AE DF G+A   S   + D+   +++++++
Sbjct: 240 ITGRNSGRYIFVEAMVEMAESDF-GKAHRESERIEQDIRLRVQNVERV 286


>UniRef50_Q0KAF7 Cluster: Cobalt-zinc-cadmium resistance protein
           czcD; n=1; Ralstonia eutropha H16|Rep:
           Cobalt-zinc-cadmium resistance protein czcD - Ralstonia
           eutropha (strain ATCC 17699 / H16 / DSM 428 / Stanier
           337)(Cupriavidus necator (strain ATCC 17699 / H16 / DSM
           428 / Stanier337))
          Length = 194

 Score = 51.6 bits (118), Expect = 4e-05
 Identities = 30/76 (39%), Positives = 39/76 (51%)

Query: 108 VLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHP 167
           V  AI  N      K      TGS ++ SE IHS  DT N+L+L  G+ +S + AD  HP
Sbjct: 36  VYGAIAANVAIAATKFVVAAVTGSSAMLSEAIHSTVDTGNELLLLVGMARSRRPADAMHP 95

Query: 168 YGYTNMRYVSSLISGV 183
           +GY    Y  SL+  V
Sbjct: 96  FGYGKELYFWSLMVAV 111


>UniRef50_Q1EYD3 Cluster: Cation efflux protein precursor; n=1;
           Clostridium oremlandii OhILAs|Rep: Cation efflux protein
           precursor - Clostridium oremlandii OhILAs
          Length = 297

 Score = 51.2 bits (117), Expect = 5e-05
 Identities = 51/251 (20%), Positives = 111/251 (44%), Gaps = 17/251 (6%)

Query: 106 RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD 165
           R+VL  I +N    L K+ A   + S +L ++ +HS +D +  + +  G+  + +  D  
Sbjct: 13  RIVLITIALNIFLLLIKVIAGIASNSTALIADGLHSGSDVITSVGVIIGMAMASKPRDEH 72

Query: 166 HPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEG 225
           H YG+  +  +++ +  + +  VG+ +  Y  ++ IL  + +    ++YF L  A+VS  
Sbjct: 73  HHYGHEKIETITTFLLSIVLIYVGAQIG-YSALSAILRKEQV---LFSYFGLFAALVSII 128

Query: 226 ATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYT 285
              +    A R G RE + +L          +     L   A+  G++ A          
Sbjct: 129 IKEIQYQIAYRVGTREKSAALIADAWHHRSDA-----LSSIASFIGILGAK--------F 175

Query: 286 GNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHD 345
           G  + D++   +V  I+  V   I       L+  SI  +++  +  ++ ++  ++ I D
Sbjct: 176 GISILDSMAGFIVSLIVIKVGVHIFKECFQELIDVSIHLDEVSNLKKIILKETSVKYISD 235

Query: 346 VKGIDIGSNLI 356
           ++    G+ ++
Sbjct: 236 LRTRKHGAKVL 246


>UniRef50_A6ECE5 Cluster: Cation efflux protein; n=1; Pedobacter sp.
           BAL39|Rep: Cation efflux protein - Pedobacter sp. BAL39
          Length = 307

 Score = 51.2 bits (117), Expect = 5e-05
 Identities = 67/279 (24%), Positives = 120/279 (43%), Gaps = 31/279 (11%)

Query: 120 LFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSL 179
           L K  A+F T S+++ ++   S+ + +      Y I+ +    D +HPYG+  + + S+ 
Sbjct: 2   LAKFVAYFMTHSNAILTDAAESIVNVLASGFAFYSIYLATLPKDENHPYGHGKVEFFSAF 61

Query: 180 ISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGA 239
           + GV I   G  + F  G   +L P  +   Y    ++G   V+    L   L  I  G 
Sbjct: 62  VEGVLIALAGLIIIFKSGY-DLLFPVAIRQLYEGAIIIG---VTGLINLFTGLYLINTGK 117

Query: 240 REANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVG 299
           R ++++L       +D      LL D     G+++    + + Q T     D++ SIL+G
Sbjct: 118 RHSSITL------EAD---GKHLLTDAVTSGGLVIG---VLLIQLTEIFWLDSVISILLG 165

Query: 300 TILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDF--MIRAIHDVKGIDIGS-NLI 356
                     I+ N   L  RS+    +DE N  L +D   +++A      ID+ +    
Sbjct: 166 --------MYIIRNGYQLTRRSV-GGLMDESNMELVKDIVGIMQAHRHDAWIDVHNLRAQ 216

Query: 357 RYKAEVDFDGRALTRSYLEKHDLNALLEDMKKIDTIDDV 395
           +Y A++  D       Y    DLN +  ++  ID + +V
Sbjct: 217 QYGADLHIDCHVTLPYYF---DLNRVHAEISSIDQLINV 252


>UniRef50_Q8PTD7 Cluster: Cobalt-zinc-cadmium resistance protein;
           n=2; Methanosarcina|Rep: Cobalt-zinc-cadmium resistance
           protein - Methanosarcina mazei (Methanosarcina frisia)
          Length = 357

 Score = 50.8 bits (116), Expect = 7e-05
 Identities = 61/284 (21%), Positives = 126/284 (44%), Gaps = 26/284 (9%)

Query: 106 RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD 165
           RV    + +N    +FKL A     S ++ ++ +HSL+D +  +++ +G   + +  D  
Sbjct: 41  RVTGVGLFVNLGLTIFKLLAGILGNSTAMVADAVHSLSDFLTDVVVIFGFKIAKKPVDES 100

Query: 166 HPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEG 225
           H YG+  +  +S+ + G+ +  V +G   Y+GV   L            F+  G +    
Sbjct: 101 HNYGHGKIETLSASLVGLMLLLV-AGQILYYGVQKTL-----------MFIEAGTLEQPA 148

Query: 226 ATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAI---- 281
              ++AL A         + +Y+Y +  +    ++ L  +         ++ C  I    
Sbjct: 149 ---IIALYAALASVISKEI-MYQYTILKARKINSMALTANAWHHRSDAFSSFCTMIGIGA 204

Query: 282 SQYTGNP--LPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFM 339
           + + G    + D L ++ +  I+  V+  I  S++  LV  S+  +   EI  ++++   
Sbjct: 205 AVFLGGKWVVLDPLMAVFLSFIILKVSLKIFHSSINELVEASLDEKTESEIRQIIQKTEG 264

Query: 340 IRAIHDVKGIDIGSNL---IRYKAEVDFD-GRALTRSYLEKHDL 379
           ++A+ ++K   IG+N+   IR K +   D G A   S   +H+L
Sbjct: 265 VKALSNLKTRRIGNNIAVDIRIKVDNALDIGEANRISIHVEHNL 308


>UniRef50_UPI0000383D2E Cluster: COG0053: Predicted Co/Zn/Cd cation
           transporters; n=1; Magnetospirillum magnetotacticum
           MS-1|Rep: COG0053: Predicted Co/Zn/Cd cation
           transporters - Magnetospirillum magnetotacticum MS-1
          Length = 460

 Score = 50.4 bits (115), Expect = 9e-05
 Identities = 32/118 (27%), Positives = 56/118 (47%), Gaps = 3/118 (2%)

Query: 107 VVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDH 166
           V ++++  +    + KL     TGS  + SE  HSL D    L+  + +    Q AD  H
Sbjct: 9   VAISSVLASAAMTVMKLVVGLMTGSLGILSEAAHSLLDMGAALLTWFAVRIGDQPADERH 68

Query: 167 PYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILD--PQPLHDFYWAYFVLGGAVV 222
           PYG+  +  VS+LI   G+  V +       V+ +L+  P  +   +WA  V+  +++
Sbjct: 69  PYGHGKVESVSALIE-TGLLFVTAAWIIKEAVSRLLESTPPEVETTWWAVAVIVVSII 125


>UniRef50_Q5P2F7 Cluster: Putative uncharacterized protein; n=1;
           Azoarcus sp. EbN1|Rep: Putative uncharacterized protein
           - Azoarcus sp. (strain EbN1) (Aromatoleum aromaticum
           (strain EbN1))
          Length = 317

 Score = 50.4 bits (115), Expect = 9e-05
 Identities = 57/216 (26%), Positives = 96/216 (44%), Gaps = 22/216 (10%)

Query: 122 KLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLIS 181
           K  AW+ TGS    S+ + SL +          +  +   ADP+HPYG+    Y S+   
Sbjct: 55  KAGAWWLTGSVGFLSDALESLVNLAGASFALLMVSLARAPADPEHPYGHGKAEYFSAAFE 114

Query: 182 GVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLG-GAVVSEGATLM-VALSAIRKGA 239
           G+ IF V + +     V  ++ PQPL         LG G V+S GA+L+ + ++ I    
Sbjct: 115 GMLIF-VAALVILATAVERLIHPQPLG-------ALGLGTVLSVGASLVNLVVARILFQV 166

Query: 240 REANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTG-NPLPDALGSILV 298
             A+ SL       +D      L+ D    AGV+      ++S +   +PL  A   + V
Sbjct: 167 GRAHRSL----ALEADAR---HLMTDVWTTAGVVAGVGLASLSGWNWLDPLVAA--GVAV 217

Query: 299 GTILGGVASFIILSNVGALVGRSIPHEQLDEINSVL 334
             +  G    ++  +V  L+ R++   ++  I +VL
Sbjct: 218 NILREGWG--LMHRSVDGLMDRALDDAEIRHIEAVL 251


>UniRef50_P96691 Cluster: YdfM protein; n=2; Bacillus|Rep: YdfM
           protein - Bacillus subtilis
          Length = 297

 Score = 50.4 bits (115), Expect = 9e-05
 Identities = 62/265 (23%), Positives = 122/265 (46%), Gaps = 16/265 (6%)

Query: 104 SGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMAD 163
           S +V L A+  N      K+       S ++F++ IHS AD V  + +   I  S +  D
Sbjct: 9   SRKVALIALIANLILMAGKVFFGLVGDSEAVFADGIHSAADVVASIAVLAVIGISNKPPD 68

Query: 164 PDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILD--PQPLHDFYWAYFVLGGAV 221
            DHP+G+     +S  I G+ +  V    S Y  +  IL     P    Y A F    A+
Sbjct: 69  QDHPFGHGKAEVISEAIVGIILVIV----SVYILIEAILSFVKGPSVPQYSALF---AAL 121

Query: 222 VSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAI 281
           +S  A  ++   +I++G +  + ++   +  + D   ++V     AA  GV++A    + 
Sbjct: 122 ISYVAKEILYRYSIKQGKKWNSKAI---IAIAYDHKGDIV--ASLAAFIGVLLAIIGNS- 175

Query: 282 SQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIR 341
             ++     DA+ S +V  ++  ++  +I  +VG L+ +S+  E ++E  +V+ +   ++
Sbjct: 176 RGWSYLLYADAIASAIVAYLIFKISMELIRPSVGVLMEKSVDPELIEEYKAVIFQCDQVK 235

Query: 342 AIHDVKGIDIGS-NLIRYKAEVDFD 365
            I  ++  + G   L+  +  +D D
Sbjct: 236 RIDRIRAREHGHYKLLDVRLSLDHD 260


>UniRef50_Q0AY41 Cluster: Putative cation efflux system protein;
           n=1; Syntrophomonas wolfei subsp. wolfei str.
           Goettingen|Rep: Putative cation efflux system protein -
           Syntrophomonas wolfei subsp. wolfei (strain Goettingen)
          Length = 319

 Score = 50.4 bits (115), Expect = 9e-05
 Identities = 50/246 (20%), Positives = 109/246 (44%), Gaps = 21/246 (8%)

Query: 120 LFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSL 179
           + K        S SL ++ +H+ +D +  L++  G   +   AD +HP+G+  + ++++L
Sbjct: 52  IIKFIMGILVNSISLIADAVHTASDVLTSLVVIIGFKLAALPADEEHPHGHGRIEFIATL 111

Query: 180 ISGVGIFCVGSGLSF-YHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKG 238
           +  + +  +  G+ F +     ++   P+     +YFV+          +M+     ++ 
Sbjct: 112 V--ISLLLIAVGIKFGFDSYKRLIANTPVAG---SYFVV---------VVMLFAGLFKEW 157

Query: 239 AREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILV 298
               ++ L + +  SS   +       T A+A V+VA + +A S++ G    DA+   +V
Sbjct: 158 MSRFSIDLGQRI--SSSTLIADAWHHRTDAIASVLVAIAILA-SKF-GYYWVDAVLGFVV 213

Query: 299 GTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDVKGIDIGSN-LIR 357
             ++      I   +   ++G     EQ+  +N +      + A+HD    D G+N ++ 
Sbjct: 214 SALIVWTGIEIFRESCSKIIG-EYDEEQVKRVNQLALAIPGVIAVHDTSVHDYGANKVVS 272

Query: 358 YKAEVD 363
              EVD
Sbjct: 273 LHIEVD 278


>UniRef50_A5Z978 Cluster: Putative uncharacterized protein; n=2;
           Bacteria|Rep: Putative uncharacterized protein -
           Eubacterium ventriosum ATCC 27560
          Length = 588

 Score = 50.4 bits (115), Expect = 9e-05
 Identities = 30/118 (25%), Positives = 59/118 (50%), Gaps = 1/118 (0%)

Query: 86  MSHTRSKDNVEEVGLKTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADT 145
           M+    K+ + +   K  + +V   +I +N    +FKL A     S ++ S+ IHS +D 
Sbjct: 23  MTRIEKKEILSDEKTKKVAMQVSTVSIVVNLLLSVFKLLAGIIGKSGAMVSDAIHSASDV 82

Query: 146 VNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILD 203
            +  I+  G+  + + +D  H YG+  +  V+++I  V +   G+G+    GV  I++
Sbjct: 83  FSSFIVIIGVSLAGKESDEGHQYGHDRLECVAAIILAVVLLITGAGIGI-DGVNKIIN 139


>UniRef50_Q7NKM3 Cluster: Gll1454 protein; n=3; Bacteria|Rep:
           Gll1454 protein - Gloeobacter violaceus
          Length = 319

 Score = 50.0 bits (114), Expect = 1e-04
 Identities = 51/213 (23%), Positives = 85/213 (39%), Gaps = 16/213 (7%)

Query: 122 KLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLIS 181
           K  A+  TGS  L S+   S  + V  L+  + +  + +  D  HP+G++   Y SS + 
Sbjct: 31  KFGAYVLTGSVGLLSDAAESGINLVTALVTFWALTVAARAPDQTHPFGHSKAEYFSSGLE 90

Query: 182 GVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGARE 241
           G  I     G++    V  + DPQPL        +   A    G    V  +A   G R 
Sbjct: 91  GALILLAAVGIA-VTAVGRLFDPQPLEQLGLGMVLSLVATALNGGVAAVLTAA---GKRL 146

Query: 242 ANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGTI 301
            +++L               LL D    AGV+V    + + Q TG  + D L ++ V   
Sbjct: 147 RSLALQADAQH---------LLTDVWTSAGVVVG---LVLVQLTGWLILDPLIALAVAVN 194

Query: 302 LGGVASFIILSNVGALVGRSIPHEQLDEINSVL 334
           +   A  ++  +   L+  ++  E    I  +L
Sbjct: 195 IVWAALRLLRESADGLMDSALSDEDTRSIERIL 227


>UniRef50_A3XEG4 Cluster: Cation efflux system protein; n=9;
           Proteobacteria|Rep: Cation efflux system protein -
           Roseobacter sp. MED193
          Length = 305

 Score = 50.0 bits (114), Expect = 1e-04
 Identities = 38/136 (27%), Positives = 70/136 (51%), Gaps = 7/136 (5%)

Query: 106 RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQM-ADP 164
           R V  AI  NG   + ++     +GS +L ++ +H+ +D  + L++A+   K  +  AD 
Sbjct: 17  RRVAIAIWANGLLTVAQIVGGILSGSLALIADALHNFSDMAS-LVIAFAARKIARRPADE 75

Query: 165 DHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGG-AVVS 223
              +GY  +  V++LI+   +  +G  L  Y G   ++DP  +    W   +LGG A+V 
Sbjct: 76  RMTFGYGRVEIVAALINYTTLIVIGFYL-IYEGGMRMIDPPEV--MGWTVVILGGIALVV 132

Query: 224 EGATLMVALSAIRKGA 239
           +  T M+  S ++KG+
Sbjct: 133 DTLTAMLTYS-MQKGS 147


>UniRef50_A5ULB6 Cluster: Cation efflux system protein; n=1;
           Methanobrevibacter smithii ATCC 35061|Rep: Cation efflux
           system protein - Methanobrevibacter smithii (strain PS /
           ATCC 35061 / DSM 861)
          Length = 301

 Score = 50.0 bits (114), Expect = 1e-04
 Identities = 61/298 (20%), Positives = 124/298 (41%), Gaps = 23/298 (7%)

Query: 101 KTRSG-RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSV 159
           +T+ G +  +  IG N    +F +     +GS++L SE  H+L+D    +I   G     
Sbjct: 5   RTKGGTKAAIVGIGSNTFLTIFNIGIGIISGSYALISEGAHTLSDVATSIIAYLGFRIGQ 64

Query: 160 QMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHG-VTGILDPQPLHDFYWAYFVLG 218
           + AD +HP G+     ++ LI  + +F          G +  I+ P+ +     +Y    
Sbjct: 65  KPADEEHPLGHGRAEAIAGLI--IVLFLTMVAYEIMTGAINKIVHPELITT--PSYLAAV 120

Query: 219 GAVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASC 278
            A++  G  L ++   I  G +  + ++   V   +   V++      A + GV  + S 
Sbjct: 121 MALIGIGVNLCISRYIIALGKKIRSPAI---VADGNHQKVDI--FSSVAILVGVFASNS- 174

Query: 279 MAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDF 338
                  G  + D +  +++G  +   A  I   N+  ++G+    E + +I     +  
Sbjct: 175 -------GYSIIDPVIGLIIGLFVLKTAYTIGKENIDNIMGKIPSKELIKDIEKAATKTP 227

Query: 339 MIRAIHDVKGIDIGS-NLIRYKAEVDFDGRALTRSYLEKHDLNALLEDMKKIDTIDDV 395
            +   H++K   +GS +++    E+D +   L  S+   H   A    +KK+  +  V
Sbjct: 228 QVLGAHNIKVEYLGSYSVVSLHIELD-ENMTLKESHKIVH--RAQNNVLKKVPLVKSV 282


>UniRef50_Q3AES4 Cluster: Cation efflux family protein; n=1;
           Carboxydothermus hydrogenoformans Z-2901|Rep: Cation
           efflux family protein - Carboxydothermus
           hydrogenoformans (strain Z-2901 / DSM 6008)
          Length = 303

 Score = 49.6 bits (113), Expect = 2e-04
 Identities = 55/242 (22%), Positives = 104/242 (42%), Gaps = 16/242 (6%)

Query: 120 LFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSL 179
           LFK+    +TGS S+ +E +HS  D +  +I  + +  + + AD  HPYG+  +  ++  
Sbjct: 21  LFKIVVGLFTGSVSIIAEGLHSGVDLLASIITFFSVKVASRPADVRHPYGHGKVENIAGT 80

Query: 180 ISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLG-GAVVS--EGATLMVALSAIR 236
           I G+ IF +G+ L     +     P+      W   V+   A+V+     TL+       
Sbjct: 81  IEGLLIF-LGAVLIIKEALPKFWHPEMPESLGWGMGVMAVSALVNFFISQTLLKIAKETD 139

Query: 237 KGAREAN-MSLYEYVMRSSDPSVNVVLLEDTA----------AVAGVIVAASCMAISQYT 285
             A EA+   L   V  S+   + ++L++ T            VAG+I+ A+     +  
Sbjct: 140 SPALEADGWHLRTDVYTSAGVLLGLLLIKLTGITYFDPILALIVAGMILKAAYEITFEGF 199

Query: 286 GNPLPDALGSILVGTILGGVASF-IILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIH 344
            N +  AL    +  I   +A++         L  R    E+  +++ V+     ++ +H
Sbjct: 200 ANMVDTALPEKEIALIKDSIANYGEKFLEFHKLRARKSGSERFIDLHLVVPEKLSVKEVH 259

Query: 345 DV 346
           D+
Sbjct: 260 DL 261


>UniRef50_Q9KDH5 Cluster: Cation efflux system; n=4;
           Bacillaceae|Rep: Cation efflux system - Bacillus
           halodurans
          Length = 300

 Score = 49.2 bits (112), Expect = 2e-04
 Identities = 27/95 (28%), Positives = 46/95 (48%), Gaps = 1/95 (1%)

Query: 131 SHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGS 190
           S +L ++ +HS +D V+ +++  G+  +    D DHPYG+     V+S+I  V +F VG 
Sbjct: 38  SKALIADAVHSASDVVSSVVVLIGVRAAKMPPDEDHPYGHGKAESVASIIVAVLLFIVGF 97

Query: 191 GLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEG 225
            ++         +P  +      Y VL    V EG
Sbjct: 98  EIA-VSAFQSFFEPVEVPRTLAIYAVLISIFVKEG 131


>UniRef50_Q2JWZ6 Cluster: Cation transporter, cation diffusion
           facilitator (CDF) family; n=7; Cyanobacteria|Rep: Cation
           transporter, cation diffusion facilitator (CDF) family -
           Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria
           bacteriumYellowstone A-Prime)
          Length = 304

 Score = 49.2 bits (112), Expect = 2e-04
 Identities = 29/102 (28%), Positives = 45/102 (44%), Gaps = 3/102 (2%)

Query: 106 RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD 165
           RV+   +G+N   F  KL     TGS SL ++ +HS+ D+ + ++       S    D D
Sbjct: 19  RVLYVTLGLNLLVFSVKLILGLATGSLSLVADALHSVTDSASNILALLAARFSSPEPDED 78

Query: 166 HPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTG-ILDPQP 206
           HPYG +    + +L  G+  F   +         G    PQP
Sbjct: 79  HPYGRSKFEAIGAL--GIAAFLGVASFEILSAAVGRFFAPQP 118


>UniRef50_Q565Y9 Cluster: Predicted Co/Zn/Cd cation transporter;
           n=1; uncultured bacterium|Rep: Predicted Co/Zn/Cd cation
           transporter - uncultured bacterium
          Length = 369

 Score = 49.2 bits (112), Expect = 2e-04
 Identities = 32/137 (23%), Positives = 65/137 (47%), Gaps = 5/137 (3%)

Query: 108 VLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHP 167
           +L ++ ++    + KL A++ T S ++ S+   S+   V   + A+ +  + + AD DHP
Sbjct: 65  ILVSLLVSVVMLVGKLSAYYLTRSTAILSDAAESIVHCVATALAAFSLWYAGRPADADHP 124

Query: 168 YGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGAT 227
           YG+  + Y S+   G  +F     +  +  + G+L    L        + GG  +     
Sbjct: 125 YGHGRIAYFSAGFEGALVFAASIAVG-WSAIAGLLRAPQLQHLGLGMAIAGGLAL---IN 180

Query: 228 LMVALSAIRKGAREANM 244
           L++ L+ +R G R+ N+
Sbjct: 181 LVLGLALLRIG-RQHNV 196


>UniRef50_A3X492 Cluster: Cation efflux transporter, CDF family
           protein; n=4; Rhodobacteraceae|Rep: Cation efflux
           transporter, CDF family protein - Roseobacter sp. MED193
          Length = 298

 Score = 49.2 bits (112), Expect = 2e-04
 Identities = 21/64 (32%), Positives = 37/64 (57%)

Query: 122 KLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLIS 181
           KL AW+ TGS +L S+ + SL +    ++    +H + + AD  HP+G+    Y S+++ 
Sbjct: 24  KLVAWWLTGSVALLSDALESLVNVGGAVMAWMAVHYAKRPADAGHPFGHYKAEYFSAVLE 83

Query: 182 GVGI 185
           G+ I
Sbjct: 84  GIMI 87


>UniRef50_A7DRF6 Cluster: Cation diffusion facilitator family
           transporter; n=1; Candidatus Nitrosopumilus maritimus
           SCM1|Rep: Cation diffusion facilitator family
           transporter - Candidatus Nitrosopumilus maritimus SCM1
          Length = 450

 Score = 49.2 bits (112), Expect = 2e-04
 Identities = 25/88 (28%), Positives = 43/88 (48%), Gaps = 1/88 (1%)

Query: 119 FLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSS 178
           FL +L     + S +L ++ IH+L D+V  L+L      +++  D +H YG+  +  +  
Sbjct: 20  FLVELVFGLVSNSLALITDSIHALLDSVVTLVLLLAARMAIKPPDAEHTYGHGKIESLGG 79

Query: 179 LISGVGIFCVGSGLSFYHGVTGILDPQP 206
           LI G+ IF +      Y  +  I  P P
Sbjct: 80  LIGGIAIFLIAC-FFIYESIHRIQSPPP 106


>UniRef50_Q2W8Q4 Cluster: Predicted Co/Zn/Cd cation transporters;
           n=3; Magnetospirillum|Rep: Predicted Co/Zn/Cd cation
           transporters - Magnetospirillum magneticum (strain AMB-1
           / ATCC 700264)
          Length = 318

 Score = 48.8 bits (111), Expect = 3e-04
 Identities = 31/117 (26%), Positives = 58/117 (49%), Gaps = 3/117 (2%)

Query: 112 IGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYT 171
           + +N    + K       GS ++ ++ ++SL D +N L++  G   S +  D +HPYG+ 
Sbjct: 18  LAVNTVLMVMKAFVGLIGGSQAMLADAMYSLKDMLNALMVVIGTTISSKPLDAEHPYGHG 77

Query: 172 NMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATL 228
            + ++ S++  V +F   +G    H V  +LD + +H       VL  A+VS G  +
Sbjct: 78  KVEFILSMVVSV-VFIGLTGYLLVHAVQILLD-ESMHRTP-HLIVLWAALVSVGVNV 131


>UniRef50_Q2W8P3 Cluster: Predicted Co/Zn/Cd cation transporters;
           n=2; Magnetospirillum|Rep: Predicted Co/Zn/Cd cation
           transporters - Magnetospirillum magneticum (strain AMB-1
           / ATCC 700264)
          Length = 333

 Score = 48.8 bits (111), Expect = 3e-04
 Identities = 51/233 (21%), Positives = 102/233 (43%), Gaps = 17/233 (7%)

Query: 120 LFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSL 179
           +FK      +GS +L +  +HS  D + + I    +  S + A+   PYGY  ++++S+ 
Sbjct: 31  VFKTALGVLSGSMALQAHSLHSFGDFLTKGINLASVKLSSRPANSAFPYGYGKVQFLSAN 90

Query: 180 ISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGA 239
             G+ +   G+    ++ VT +          WA F   GA++S G T  +    +R  A
Sbjct: 91  FIGISLM-AGAAAMLWYNVTHLGSGHVQVPEVWAVF---GALISAG-TAELMHRYLRCVA 145

Query: 240 REANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVG 299
              N      +  ++D   +       A +AG++++          G    D L +ILV 
Sbjct: 146 EHTNSP--AIMAAAADNRGDA--YSSLAVLAGIVLS--------ILGWVAADHLAAILVS 193

Query: 300 TILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDVKGIDIG 352
            ++  + + I   ++  L+  S+P  ++D I  +L       ++ D++G  +G
Sbjct: 194 LLVLRIGAVIAWDSIHGLMDGSVPSHRIDGIRQLLAAHHPGVSVVDLRGRRMG 246


>UniRef50_O85143 Cluster: Transport protein; n=35; Bacteria|Rep:
           Transport protein - Staphylococcus aureus
          Length = 326

 Score = 48.8 bits (111), Expect = 3e-04
 Identities = 55/260 (21%), Positives = 107/260 (41%), Gaps = 17/260 (6%)

Query: 86  MSHTRSKDNVEEVGLKTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADT 145
           MSH+    +     + T +  V+  +  I G     ++       S +L  + IH  +DT
Sbjct: 1   MSHSHHHHDHMHSHVTTNNKEVLFISFLIIGLYMFIEIIGGLLANSLALLRDGIHMSSDT 60

Query: 146 VNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQ 205
            +  +       + + A     +GY     +++L +GV +F + S L  +  +T    P 
Sbjct: 61  FSLGVALVAFIYAEKNATTTKTFGYKRFEVLAALFNGVTLFVI-SILIVFEAITRFFVPS 119

Query: 206 PLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLED 265
            +         + G +V+    ++VA    + G    N++     MR +   V    + D
Sbjct: 120 EVQSKEMLIISIIGLIVN----IVVAFFRFKGGDTSHNLN-----MRGAFLHV----IGD 166

Query: 266 TAAVAGVIVAASCMAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHE 325
                G I AA  +    +T   + D + SILV  I+   A  I  S++  L+  +    
Sbjct: 167 LLGSVGAITAAILIWAFGWT---IADPIASILVSVIILKSAWGITKSSINILMEGTPSDV 223

Query: 326 QLDEINSVLERDFMIRAIHD 345
            +DE+ + + +D  I+++HD
Sbjct: 224 DIDEVITTITKDSRIQSVHD 243


>UniRef50_A5FYR2 Cluster: Cation diffusion facilitator family
           transporter precursor; n=1; Acidiphilium cryptum
           JF-5|Rep: Cation diffusion facilitator family
           transporter precursor - Acidiphilium cryptum (strain
           JF-5)
          Length = 295

 Score = 48.8 bits (111), Expect = 3e-04
 Identities = 49/214 (22%), Positives = 93/214 (43%), Gaps = 18/214 (8%)

Query: 122 KLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLIS 181
           K  AW  + S +L+S+ + SL +    +++   +  + + AD +HPYG+     +S++  
Sbjct: 22  KAAAWRVSHSAALYSDALESLVNVFAAVMVMIALKAAAKPADSEHPYGHAKAELLSAVAE 81

Query: 182 GVGIFCVGSGLSFYHGVTGILDPQ-PLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGAR 240
           G G+    + L      + IL P+ P+           G VV+     + AL+  R GA 
Sbjct: 82  G-GMIIFAAVLILERAASTILAPRLPVAPELGLGLNAAGGVVN----ALWALALGRSGAT 136

Query: 241 EANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGT 300
                  ++   ++D      L+ D     G+I   S   ++     P+ D L +I V  
Sbjct: 137 R------KFPALAAD---QAHLIADAITTLGIIGGLSLAILANL---PVLDPLIAIAVAA 184

Query: 301 ILGGVASFIILSNVGALVGRSIPHEQLDEINSVL 334
            +  +    +L  + AL+ R+ P E +D I  ++
Sbjct: 185 QIAFMGGRTVLRALSALLDRAPPPEMVDRIRHLV 218


>UniRef50_Q5ZTX4 Cluster: Cation efflux family protein; n=4;
           Legionella pneumophila|Rep: Cation efflux family protein
           - Legionella pneumophila subsp. pneumophila (strain
           Philadelphia 1 /ATCC 33152 / DSM 7513)
          Length = 387

 Score = 48.4 bits (110), Expect = 4e-04
 Identities = 57/291 (19%), Positives = 125/291 (42%), Gaps = 21/291 (7%)

Query: 106 RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD 165
           +V L    IN    + K+   F   SH+L ++ +HS++D +  + + +        AD  
Sbjct: 19  KVTLIGAFINALLGVVKMIGGFLYHSHALIADGVHSISDLITDVTVVFASKYGSVSADDS 78

Query: 166 HPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEG 225
           HPYG+  +   ++L+  + +   G G++ +  +  +L        + +  ++  ++++  
Sbjct: 79  HPYGHQRIETAATLLLSLLLILAGCGIA-WDALDELLKSDHTMPNWLSIPIVCFSIIANE 137

Query: 226 ATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYT 285
           A L      + K      ++   +  RS   S  VVL+    ++AG++            
Sbjct: 138 A-LFHYTRHVGKKISSQLITANAWHHRSDAASSIVVLIGLIGSLAGLVYL---------- 186

Query: 286 GNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHD 345
                DA+ +++V  ++  +      ++V  LV  ++  E   +I  V++    ++ IH 
Sbjct: 187 -----DAIAAVIVSLMIIKMGWSYGWNSVKELVDTAVDAELFSQIERVIQSIDGVKRIHQ 241

Query: 346 VKGIDIGSN-LIRYKAEVDFDGRALTRSYLEKHDLNALLEDMKKIDTIDDV 395
           ++   +GS+ LI     V          Y+ +H  + L   +K+ID + DV
Sbjct: 242 LRSRFMGSDVLIDVHILVSPKISVSEGHYIAQHVHHTL---VKEIDCVKDV 289


>UniRef50_A7GZ19 Cluster: Pantothenate metabolism flavoprotein; n=2;
           Campylobacter|Rep: Pantothenate metabolism flavoprotein
           - Campylobacter curvus 525.92
          Length = 311

 Score = 48.4 bits (110), Expect = 4e-04
 Identities = 47/225 (20%), Positives = 103/225 (45%), Gaps = 16/225 (7%)

Query: 120 LFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSL 179
           + K  A   +GS ++ S  I S+ D +  L+  + + KS   A+ +  +GYT +  +++L
Sbjct: 37  VIKFIAGIASGSVAVMSSAIDSILDFIVSLLNFFALKKSRAAANENFNFGYTKLEAMAAL 96

Query: 180 ISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGA 239
             GV I  + + + FY  +          D   + +V+  ++V  GA L+  LS++ K  
Sbjct: 97  FEGVFIIGIAAFI-FYESILKFKQDDAAIDVGASLWVMCFSLVVTGA-LIAFLSSVAK-- 152

Query: 240 REANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVG 299
           R  N+     ++R+           + A +A +IV        ++TG  + DA+  +++ 
Sbjct: 153 RTDNL-----ILRADALHYKSDFYTNLAVIAALIVI-------KFTGLMIVDAVLGLIIS 200

Query: 300 TILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIH 344
             +   A  ++  +   L+ R++    ++ I ++++    I + H
Sbjct: 201 GYIAHSAVNLMKESFAVLLDRALEPAMIEAIKNMIKSKKEILSFH 245


>UniRef50_Q3A4F2 Cluster: Putative transport system permease
           protein; n=1; Pelobacter carbinolicus DSM 2380|Rep:
           Putative transport system permease protein - Pelobacter
           carbinolicus (strain DSM 2380 / Gra Bd 1)
          Length = 314

 Score = 48.0 bits (109), Expect = 5e-04
 Identities = 32/105 (30%), Positives = 52/105 (49%), Gaps = 8/105 (7%)

Query: 101 KTRSGRVVL-TAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSV 159
           K R+ R+ + TA G+     L KL   F TGS ++ S  I SL D V  +     I ++ 
Sbjct: 8   KIRAARISMATATGLT----LLKLVTGFLTGSMAVLSSAIDSLLDIVMSVANFLAIRQAE 63

Query: 160 QMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHG---VTGI 201
           Q  DP HP+G+     +++++  + I   G  + +  G   +TGI
Sbjct: 64  QPPDPKHPFGHGKFETLATIVQALAIGLSGGWVCYESGRRLLTGI 108


>UniRef50_Q01VH6 Cluster: Cation diffusion facilitator family
           transporter precursor; n=1; Solibacter usitatus
           Ellin6076|Rep: Cation diffusion facilitator family
           transporter precursor - Solibacter usitatus (strain
           Ellin6076)
          Length = 291

 Score = 48.0 bits (109), Expect = 5e-04
 Identities = 36/135 (26%), Positives = 63/135 (46%), Gaps = 5/135 (3%)

Query: 106 RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD 165
           RV +  + ++G   L K+ A     S ++ ++ + S AD +    + +G+  + + AD +
Sbjct: 6   RVAVAGMLVSGALALIKIFAGLAGNSTAVVADGLESAADVIASGFVLFGLTIAARPADDN 65

Query: 166 HPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEG 225
           HPYG+  +  ++ L+  +G    G G     G    L  QP      A FV+G  V+S  
Sbjct: 66  HPYGHGRVETLTGLV--IGFVLTGGGALISWGSLRRLG-QPTEPL--AAFVIGPLVLSLF 120

Query: 226 ATLMVALSAIRKGAR 240
           A + +A    R G R
Sbjct: 121 AKMGLAAMKFRYGKR 135


>UniRef50_A1WYJ4 Cluster: Cation diffusion facilitator family
           transporter; n=3; Ectothiorhodospiraceae|Rep: Cation
           diffusion facilitator family transporter -
           Halorhodospira halophila (strain DSM 244 / SL1)
           (Ectothiorhodospirahalophila (strain DSM 244 / SL1))
          Length = 389

 Score = 48.0 bits (109), Expect = 5e-04
 Identities = 68/285 (23%), Positives = 115/285 (40%), Gaps = 29/285 (10%)

Query: 86  MSHTRSKDNVEEVGLKTRSGRVVLTAIGIN---GCNFLFKLCAWFYTGSHSLFSECIHSL 142
           MS  RS   + E   + +  RV L    IN   GC    K+ A +   S +L  + +HSL
Sbjct: 1   MSGRRSATAIAEDPARAKR-RVTLIGGVINLFLGCG---KIAAGWLGQSQALVVDGVHSL 56

Query: 143 ADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGIL 202
           +D  +  ++        Q AD DHPYG+  +   ++   G  +  V +G   Y  V  +L
Sbjct: 57  SDLASDALVYVAAAYGSQEADSDHPYGHARIETAATAGIGAVLLLVAAGF-IYDAVQRLL 115

Query: 203 -DPQPLHDFYWAYF--VLGGAVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVN 259
             P+ L    W      L   V+ EG        A R  +   + + + +    SD   +
Sbjct: 116 ITPESLWVPGWLALGVALASLVIKEGLYHYTRWVAYRAHSNLIHANAWHH---RSDALSS 172

Query: 260 VVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVG 319
           VV++     + GV++           G P  DA+ +I+V  +L  V       +V  LV 
Sbjct: 173 VVVV---GGIVGVLL-----------GLPWLDAVAAIVVAVMLAHVGITFAWRSVCELVD 218

Query: 320 RSIPHEQLDEINSVLERDFMIRAIHDVKGIDIGSN-LIRYKAEVD 363
             +   Q+  I  ++     +R +H ++   +    LI    +VD
Sbjct: 219 TGLDPAQVAHIERLVSEIDGVRDVHGLRSRHMAEEALIDLHIQVD 263


>UniRef50_A1HSL0 Cluster: Cation diffusion facilitator family
           transporter; n=1; Thermosinus carboxydivorans Nor1|Rep:
           Cation diffusion facilitator family transporter -
           Thermosinus carboxydivorans Nor1
          Length = 295

 Score = 48.0 bits (109), Expect = 5e-04
 Identities = 28/79 (35%), Positives = 40/79 (50%), Gaps = 3/79 (3%)

Query: 100 LKTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSV 159
           LK R+ R+ + +   N    L KL   FY+G+ S+ SE  HS  D +  LI  Y + KS 
Sbjct: 7   LKQRTARLSVIS---NTLLVLLKLVVGFYSGAVSIISEAAHSGVDLLAALIAYYAVRKSS 63

Query: 160 QMADPDHPYGYTNMRYVSS 178
           Q  D  H YG+     +S+
Sbjct: 64  QPPDAQHAYGHGKFENLSA 82


>UniRef50_Q5LTM6 Cluster: Cation efflux system protein; n=13;
           Alphaproteobacteria|Rep: Cation efflux system protein -
           Silicibacter pomeroyi
          Length = 320

 Score = 47.6 bits (108), Expect = 6e-04
 Identities = 34/124 (27%), Positives = 62/124 (50%), Gaps = 4/124 (3%)

Query: 111 AIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQM-ADPDHPYG 169
           AI +N    L ++     +GS +L ++ +H+ +D V  LI+A+G  +  +  AD    YG
Sbjct: 38  AIAVNMVLTLAQVVGGLLSGSLALIADALHNFSDAV-ALIIAFGARRIARRPADARMSYG 96

Query: 170 YTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLM 229
           Y     +++LI+   +  +   L  Y G+   LDPQP+ D +   ++   A+V +  T  
Sbjct: 97  YGRAEVIAALINYTTLIVLALYL-VYEGIMRFLDPQPI-DGWLVVWIAALALVIDLVTAA 154

Query: 230 VALS 233
           +  S
Sbjct: 155 LTWS 158


>UniRef50_Q6QSW0 Cluster: Cation efflux facilitator; n=1;
           Enterococcus faecium|Rep: Cation efflux facilitator -
           Enterococcus faecium (Streptococcus faecium)
          Length = 307

 Score = 47.6 bits (108), Expect = 6e-04
 Identities = 28/107 (26%), Positives = 51/107 (47%), Gaps = 6/107 (5%)

Query: 118 NFLFKLCAWFYTG---SHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMR 174
           NF+F +  +F+     S S+ S+ +H L D+++     +    S +  D    +GY    
Sbjct: 32  NFIFSMIEFFFGSLFNSVSIMSDAVHDLGDSISIGFAWFFQGYSEKQQDEQFTFGYNRFS 91

Query: 175 YVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLH--DFYWAYFVLGG 219
            + +LI+GV +   GS    Y  +  ++DPQP++    +W   V  G
Sbjct: 92  LLGALITGV-VLIGGSFFMIYRSIPRLIDPQPVNYSGMFWLSLVAIG 137


>UniRef50_Q03ZB0 Cluster: Co/Zn/Cd efflux system component; n=1;
           Leuconostoc mesenteroides subsp. mesenteroides ATCC
           8293|Rep: Co/Zn/Cd efflux system component - Leuconostoc
           mesenteroides subsp. mesenteroides (strain ATCC 8293
           /NCDO 523)
          Length = 305

 Score = 47.6 bits (108), Expect = 6e-04
 Identities = 49/216 (22%), Positives = 94/216 (43%), Gaps = 11/216 (5%)

Query: 109 LTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPY 168
           L  I +N    L +L       S +LF++  H+L+D +  +I    +      A   H Y
Sbjct: 16  LIGISLNMIFVLSELVFAKLAHSTALFADAFHNLSDVLALMIAWLAVVVFGLQATKRHTY 75

Query: 169 GYTNMRYVSSLISGV-GIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGAT 227
           G+ NM  ++S+ + +  IF V +   FY  +  ++ P+      W   V    V + G  
Sbjct: 76  GWHNMSILASVFNTILLIFAVIT--IFYESIRNLILPENTVTTGWLVMV----VAAVGIV 129

Query: 228 LMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGN 287
           +  A + + K +   +   + +    +  +  + LL D     GVI+A     + Q TG 
Sbjct: 130 INFATAMLFKASGVPDEHGHHHEQDLNAKTAYIHLLADAGVSVGVIIAG---LLIQVTGW 186

Query: 288 PLPDALGSILVGTILGGVASFIILSNVGALVGRSIP 323
            + D + S+++G I+  V S+ ++ +   L    +P
Sbjct: 187 HVIDPIVSMIIGVII-AVTSWPVMKSTFNLALNGVP 221


>UniRef50_Q8KEZ4 Cluster: Cation efflux family protein; n=6;
           Chlorobiaceae|Rep: Cation efflux family protein -
           Chlorobium tepidum
          Length = 463

 Score = 47.2 bits (107), Expect = 8e-04
 Identities = 38/142 (26%), Positives = 62/142 (43%), Gaps = 4/142 (2%)

Query: 107 VVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDH 166
           V L+++  +      KL     TGS  + SE  HS  D     +  + +  S + AD  H
Sbjct: 11  VALSSVAASLLLTAMKLVVGLMTGSIGILSEAAHSAIDFGAAALTWFAVRISDKPADKKH 70

Query: 167 PYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGA 226
            YG+T +  VS+LI   G+  + S    Y  VT +L      +  W  + +   ++S   
Sbjct: 71  HYGHTKIESVSALIE-TGLLILTSVWIIYEAVTRLLSGTTEIEVTW--YAIAVIIISIIV 127

Query: 227 TLMVALSAIRKGAREANMSLYE 248
            +  A SA++K A+E      E
Sbjct: 128 DISRA-SALKKVAKETKSQALE 148


>UniRef50_A7HL40 Cluster: Cation diffusion facilitator family
           transporter; n=1; Fervidobacterium nodosum Rt17-B1|Rep:
           Cation diffusion facilitator family transporter -
           Fervidobacterium nodosum Rt17-B1
          Length = 324

 Score = 47.2 bits (107), Expect = 8e-04
 Identities = 59/242 (24%), Positives = 115/242 (47%), Gaps = 27/242 (11%)

Query: 107 VVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHK-SVQMADPD 165
           VVL   GI    F+  + A    GS +L S+ +H+L+D ++ +ILAY  HK S++ A+  
Sbjct: 43  VVLLNFGITLAEFIGGMLA----GSLALVSDSMHNLSDALS-IILAYFAHKISLRGANKG 97

Query: 166 HPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEG 225
             +GY   + +S+ ++ V +  + + L     V  ++ P+ +H       ++G   +   
Sbjct: 98  KTFGYGRAKIISAFVNSVTLMVI-TVLLIKEAVLRLIKPEFVHSD--TVIIVGTIGLIAN 154

Query: 226 ATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYT 285
              M+ L    KG  E ++++    +         +L +  ++VA V+ A     ++ YT
Sbjct: 155 ILSMIFL----KGHSEKDINIKSAYLH--------MLGDAFSSVAVVLGAILIKYLNIYT 202

Query: 286 GNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHE-QLDEINSVLERDFMIRAIH 344
            +P+     +I +   +G  +  I++ ++  L+ +S PH   +DEI   LE    I  +H
Sbjct: 203 IDPIL----TIFIALYIGKESFEILIKSLNVLM-QSTPHNIDVDEIIKRLENISEIENVH 257

Query: 345 DV 346
            V
Sbjct: 258 HV 259


>UniRef50_A1VH99 Cluster: Cation diffusion facilitator family
           transporter; n=2; Desulfovibrio vulgaris subsp.
           vulgaris|Rep: Cation diffusion facilitator family
           transporter - Desulfovibrio vulgaris subsp. vulgaris
           (strain DP4)
          Length = 303

 Score = 47.2 bits (107), Expect = 8e-04
 Identities = 31/141 (21%), Positives = 61/141 (43%), Gaps = 4/141 (2%)

Query: 106 RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD 165
           R +  ++    C  + K+ A+  T S +L S+   S+ + V      + ++ +    D  
Sbjct: 7   RAIALSLVCGVCILVLKMLAYLVTDSAALMSDAFESIVNVVASAFTMWTLYVAQTPPDRR 66

Query: 166 HPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEG 225
           HPYG+  + + +    G  +     G+        I++P+ +         LG +VV+  
Sbjct: 67  HPYGHGRVEFFAVFFEGALVIVAALGI-IVAAAPRIIEPRAMVQL---DIGLGLSVVASA 122

Query: 226 ATLMVALSAIRKGAREANMSL 246
             L++ L  IR G RE  ++L
Sbjct: 123 INLVLGLYLIRVGRREDRLAL 143


>UniRef50_Q311T6 Cluster: Cation diffusion facilitator family
           transporter; n=1; Desulfovibrio desulfuricans G20|Rep:
           Cation diffusion facilitator family transporter -
           Desulfovibrio desulfuricans (strain G20)
          Length = 314

 Score = 46.8 bits (106), Expect = 0.001
 Identities = 45/184 (24%), Positives = 78/184 (42%), Gaps = 8/184 (4%)

Query: 106 RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD 165
           RV    + +N     FK+ A     S ++ ++ IHSL+D V  +++  G+      AD +
Sbjct: 18  RVTWIGLWLNLALAAFKIMAGTAGHSRAVVADGIHSLSDLVTDVVVLVGVRFWSAPADEE 77

Query: 166 HPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYF--VLGGAVVS 223
           HP+G+  M  + +++  +G+   G+ +         +  + +H      F   +   VV 
Sbjct: 78  HPHGHQRMETMVTVV--IGLLLAGAAVGIAWDAIAAMGRESVHRRGAVAFGAAVLSIVVK 135

Query: 224 EGA---TLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMA 280
           EG    TL  A  A R  A EAN   +     SS P+   V L       GV   A  + 
Sbjct: 136 EGLYRWTLRAARKA-RSSALEANAWHHRTDALSSIPAAAAVGLAWFVPAWGVADLAGALV 194

Query: 281 ISQY 284
           ++ +
Sbjct: 195 VAVF 198


>UniRef50_A6CU38 Cluster: Cation efflux family protein; probable
           cobalt-zinc-cadmium resistance protein; n=1; Bacillus
           sp. SG-1|Rep: Cation efflux family protein; probable
           cobalt-zinc-cadmium resistance protein - Bacillus sp.
           SG-1
          Length = 308

 Score = 46.8 bits (106), Expect = 0.001
 Identities = 41/168 (24%), Positives = 72/168 (42%), Gaps = 7/168 (4%)

Query: 131 SHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGS 190
           S +L ++ +HS +D    L +  G+  + Q  D DHPYG+     ++++I  V +F VG 
Sbjct: 37  SKALIADAVHSASDVAGSLAVYIGLRAAKQPPDDDHPYGHGKAESIAAIIVAVLLFLVGI 96

Query: 191 GLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGAREANMSLYEYV 250
            +     +     P         Y V+ G VV E   +      + K  +   + +  Y 
Sbjct: 97  EIG-KSSIESFFHPISPPTSIAIYAVIFGIVVKE--AMFQYKYKLGKKLKSDALIVNAYE 153

Query: 251 MRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILV 298
            RS   S    L+   AA+ G ++    +   +Y G+P+     S+LV
Sbjct: 154 HRSDVYSSIAALVGIGAAMLGGVLGIGWL---EY-GDPVAGVFVSLLV 197


>UniRef50_A3CRV2 Cluster: Cation diffusion facilitator family
           transporter; n=1; Methanoculleus marisnigri JR1|Rep:
           Cation diffusion facilitator family transporter -
           Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498
           / JR1)
          Length = 305

 Score = 46.8 bits (106), Expect = 0.001
 Identities = 26/109 (23%), Positives = 54/109 (49%), Gaps = 4/109 (3%)

Query: 99  GLKTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKS 158
           G K R  R+ +  + +N    L K+      GS S+ ++  HS  D+++ +I    ++ +
Sbjct: 20  GRKVR--RIFIIVLALNLAVALAKVVFGLLAGSVSMVADAFHSGFDSLSNVIGIVALYFA 77

Query: 159 VQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSF--YHGVTGILDPQ 205
            +  DP+HPYG+  +  + +L+ G  +     G+ +  YH +   + P+
Sbjct: 78  GKPPDPEHPYGHGKIETLGTLVIGAMLLLTAGGILYEGYHRLVEAVAPE 126


>UniRef50_Q9KEY7 Cluster: Cation efflux system; n=11; Bacillus|Rep:
           Cation efflux system - Bacillus halodurans
          Length = 307

 Score = 46.4 bits (105), Expect = 0.001
 Identities = 21/76 (27%), Positives = 39/76 (51%)

Query: 114 INGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNM 173
           +NG   L K    + +GS +L ++  HS +D    + +  G+  + +  D DHPYG+   
Sbjct: 18  VNGLLALMKGVIGWLSGSRALIADAAHSASDVAGSIAVLAGLRTAKKPPDADHPYGHGKA 77

Query: 174 RYVSSLISGVGIFCVG 189
             V+++I  + +  VG
Sbjct: 78  ENVATIIVAILLIVVG 93


>UniRef50_Q57BV0 Cluster: Cation efflux family protein; n=9;
           Rhizobiales|Rep: Cation efflux family protein - Brucella
           abortus
          Length = 302

 Score = 46.4 bits (105), Expect = 0.001
 Identities = 54/227 (23%), Positives = 102/227 (44%), Gaps = 17/227 (7%)

Query: 122 KLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLIS 181
           K  A+  TGS +L+S+ + S+ + +  +   + I  S   AD +HP+G+    Y+S+++ 
Sbjct: 25  KYVAYALTGSVALYSDALESIVNVIAAIGAWWAIRVSYLPADDNHPFGHHKAEYISAVVE 84

Query: 182 GVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGARE 241
           GV +  V + L F      +  P+ L +    +  LG  + +     + A   IR G + 
Sbjct: 85  GV-LITVAALLIFREAWFALETPRMLDE---PWLGLGINMAAAAINGLWATLLIRTGRKF 140

Query: 242 ANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGTI 301
            + +L       +D      ++ D    AGV+V    + +   TG  + D L +ILV   
Sbjct: 141 RSPAL------EAD---GKHIMTDVFTSAGVLVGLVGVVV---TGWSVLDPLLAILVAIN 188

Query: 302 LGGVASFIILSNVGALVGRSI-PHEQLDEINSVLERDFMIRAIHDVK 347
           +      +I S+V  L+  ++ P E++   N +         +HD+K
Sbjct: 189 ILWQGWHVINSSVQGLMDIAVEPTEEMRIRNVISANAGGAIEVHDLK 235


>UniRef50_Q2RHV4 Cluster: Cation diffusion facilitator family
           transporter; n=2; Bacteria|Rep: Cation diffusion
           facilitator family transporter - Moorella thermoacetica
           (strain ATCC 39073)
          Length = 308

 Score = 46.4 bits (105), Expect = 0.001
 Identities = 58/241 (24%), Positives = 103/241 (42%), Gaps = 26/241 (10%)

Query: 100 LKTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSV 159
           ++TR+ RV   +I  N    L KL   ++  S S+ SE IHS  D V   I  + + ++ 
Sbjct: 3   VRTRAARV---SIFSNIILVLGKLGIGYWMHSVSVMSEAIHSGLDLVAAAIAYFSVREAS 59

Query: 160 QMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGG 219
           + AD +H YG+  +  +S  I  + IF     +  Y  +                F+ G 
Sbjct: 60  KPADAEHRYGHGKIENISGTIEALLIFLAALWI-IYEAI--------------KRFISGS 104

Query: 220 AVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAV-AGVIVAASC 278
             +SE  T +    A+  GA   N  +  Y+ R +  + ++ L  D   +   V  +A  
Sbjct: 105 HAISEPLTGV----AVMGGAGVVNYLVSRYLFRVAKDTDSIALEADAWHLRTDVYTSAGV 160

Query: 279 M---AISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLE 335
           M   A   +TG    D L +++V  ++   A  +    +  L+  S+P E+ + I  ++ 
Sbjct: 161 MLGLAALYFTGFQWLDPLVALVVAAMIIKAAYHLTREAMLPLMDVSLPAEEEEVIKEIIA 220

Query: 336 R 336
           R
Sbjct: 221 R 221


>UniRef50_A3ZLV0 Cluster: Putative uncharacterized protein; n=1;
           Blastopirellula marina DSM 3645|Rep: Putative
           uncharacterized protein - Blastopirellula marina DSM
           3645
          Length = 282

 Score = 46.0 bits (104), Expect = 0.002
 Identities = 19/59 (32%), Positives = 36/59 (61%)

Query: 120 LFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSS 178
           + KL      GS +L S+ I+SL D++  +++ +G+  + + AD +HPYG+T    V++
Sbjct: 9   IVKLAGGVLGGSFALISDAINSLGDSLTSIVVIFGLWYAQRPADEEHPYGHTRAEAVAA 67


>UniRef50_A3EVG9 Cluster: Putative Co/Zn/Cd cation transporter; n=1;
           Leptospirillum sp. Group II UBA|Rep: Putative Co/Zn/Cd
           cation transporter - Leptospirillum sp. Group II UBA
          Length = 315

 Score = 46.0 bits (104), Expect = 0.002
 Identities = 54/218 (24%), Positives = 91/218 (41%), Gaps = 22/218 (10%)

Query: 128 YTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFC 187
           ++GS SL S+  H++AD +  L L      + +     +PYGY     ++ +   VG+  
Sbjct: 53  FSGSVSLLSDAFHNVADGLTGLPLWLAFSLAAKRPSLRYPYGYGKFEDLAGIFI-VGLIF 111

Query: 188 VGSGLSFYHGVTGILDPQPLHDFYWAYFV-LGGAVVSEGATLMVALSAIRKGAREANMSL 246
             +G+S          PQ  H   W     L G + +E     VA   IR G +  ++SL
Sbjct: 112 FSAGVSLVRSGEKFFHPQVFHHPGWVTLASLTGFLANEA----VAFLRIRAGRKTGSISL 167

Query: 247 YEYVMRSS-DPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGTILGGV 305
                 +  D   ++ +L     VAG +           TG+PL D +  I++G  +  +
Sbjct: 168 VADGQHARVDGFTSLTVL---VGVAGSV-----------TGHPLWDPVVGIVLGISVLWI 213

Query: 306 ASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAI 343
           A   ++ +VG  +   I  E L+ I         IRA+
Sbjct: 214 A-LRMMRDVGLHLSDGIEPETLEIIRKAASDSCAIRAV 250


>UniRef50_A1TZF9 Cluster: Cation diffusion facilitator family
           transporter; n=2; Marinobacter|Rep: Cation diffusion
           facilitator family transporter - Marinobacter aquaeolei
           (strain ATCC 700491 / DSM 11845 / VT8)(Marinobacter
           hydrocarbonoclasticus (strain DSM 11845))
          Length = 387

 Score = 46.0 bits (104), Expect = 0.002
 Identities = 53/270 (19%), Positives = 111/270 (41%), Gaps = 19/270 (7%)

Query: 87  SHTRSKDNVEEVGLKTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTV 146
           SH R ++N+E    K  + RV +  + ++    + K+       S +L  + IHS  D  
Sbjct: 8   SHQR-QNNLESE--KHAATRVTIIGMILDAVLGIIKVIGGTLFNSQALLVDGIHSFTDVA 64

Query: 147 NQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQP 206
           +  ++   +  S +  D D+PYG+  +  + +L+ G  +  VG+ L+ +  +  +L  + 
Sbjct: 65  SDWVVLAVMRLSRKEPDADYPYGHQRIETLGTLVLGSILIAVGAALA-WENILRLLSGE- 122

Query: 207 LHDFYWAYFVLGGAVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDT 266
                 A  V G  V+   A  +     I +  R   M +       SD  +       T
Sbjct: 123 ------AQLVPGWPVLVAAAASVAGKEWIYRYTRHVGMKI------RSDLIIANAWHSRT 170

Query: 267 AAVAGVIVAASCMAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQ 326
            A + V+V  S   I    G    D + ++L+  I+  +       +V  LV   +  + 
Sbjct: 171 DAFSSVVVLVS--TIGAMLGFVWLDVVAAVLIAAIIVHIGWKFTWDSVKELVDTGLSEDD 228

Query: 327 LDEINSVLERDFMIRAIHDVKGIDIGSNLI 356
              + ++      +R +H+++   +G +++
Sbjct: 229 TRMLKTIALETDGVRNVHELRSRRMGHDIL 258


>UniRef50_Q5L2G4 Cluster: Cation efflux transporter; n=5;
           Bacillaceae|Rep: Cation efflux transporter - Geobacillus
           kaustophilus
          Length = 315

 Score = 45.6 bits (103), Expect = 0.003
 Identities = 73/320 (22%), Positives = 133/320 (41%), Gaps = 29/320 (9%)

Query: 88  HTRSKDNVEEVGLKTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVN 147
           H    D+  E   K  +  +++TA GI     L +      T S +L S+  H L+D  +
Sbjct: 19  HGHHHDHSREGNKKGLTIALLITA-GI----MLLEFFGGLITNSLALLSDSGHMLSDASS 73

Query: 148 QLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPL 207
            ++    I  + + A P+  YG+     +++L +GV +F + +G   +  +    +P  +
Sbjct: 74  LVLSLVAIWFATKPASPNKTYGFYRFEILAALFNGVTLFVI-AGFIIWEAIERFYNPPTV 132

Query: 208 HDFYWAYFVLGGAVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTA 267
                       A +   A L+ A + ++KG  + N++L          S  + ++ D  
Sbjct: 133 ASGSMMLI----ASIGLFANLLSAWALMKKGDVKNNVNL---------RSAYLHVIGDAL 179

Query: 268 AVAGVIVAASCM-AISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALV-GRSIPHE 325
              G I+A   M   S Y  +P+     SILV  ++   A  +I   V  L+ G  I  +
Sbjct: 180 GSVGAIIAGLVMWLFSWYVADPII----SILVALLILKGAWGVIKHTVHILMEGTPITID 235

Query: 326 QLDEINSVLERDFMIRAIHDVKGIDIGSNLIRYKAEVDFDGRALTRSYLEKHDLNALLED 385
           Q +E+   LE    +  +HD+    I S L      +  +    ++  L+  +    +ED
Sbjct: 236 Q-NEVKKALESIEGVINVHDLHIWTITSGLDSLSCHILIEDHQDSQKVLQ--EAIHFIED 292

Query: 386 MKKID-TIDDVETFLLKHGE 404
             KI      +ET  + HGE
Sbjct: 293 HFKIQHATIQIETSQIHHGE 312


>UniRef50_Q1NQB8 Cluster: Cation efflux protein; n=2; delta
           proteobacterium MLMS-1|Rep: Cation efflux protein -
           delta proteobacterium MLMS-1
          Length = 304

 Score = 45.6 bits (103), Expect = 0.003
 Identities = 32/113 (28%), Positives = 57/113 (50%), Gaps = 11/113 (9%)

Query: 85  EMSHTRSKDNVEEVGLKTRSGRVVLTAIGINGCNFLFKLCAWFY---TGSHSLFSECIHS 141
           E  HT  +D       + R GR+  T IGI G N L  L        +GS +L ++ +HS
Sbjct: 5   EQDHTIGQDE------RYRQGRLA-TWIGIIG-NVLLALLKGVIGALSGSLALIADAVHS 56

Query: 142 LADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSF 194
           L+D ++ L++  G+  S   AD +H YG+     +++ I  + +    +G+++
Sbjct: 57  LSDVLSSLVVLAGLKYSQLPADANHHYGHAKAESIAAKIVAIMLLVAAAGIAW 109


>UniRef50_A6LXL8 Cluster: Cation diffusion facilitator family
           transporter; n=3; Clostridiales|Rep: Cation diffusion
           facilitator family transporter - Clostridium
           beijerinckii NCIMB 8052
          Length = 298

 Score = 45.6 bits (103), Expect = 0.003
 Identities = 24/69 (34%), Positives = 34/69 (49%)

Query: 115 NGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMR 174
           N      KL     TGS S+ SE IHS  D +  +I  + +  S + AD  HPYG+  + 
Sbjct: 15  NSILITLKLIVGLATGSVSIISEAIHSTMDLLAAIIAFFSVKISDKPADDIHPYGHGKIE 74

Query: 175 YVSSLISGV 183
            VS +I  +
Sbjct: 75  NVSGVIEAI 83


>UniRef50_A1SZS2 Cluster: Iron and zinc efflux system protein; n=4;
           Gammaproteobacteria|Rep: Iron and zinc efflux system
           protein - Psychromonas ingrahamii (strain 37)
          Length = 318

 Score = 45.6 bits (103), Expect = 0.003
 Identities = 65/295 (22%), Positives = 119/295 (40%), Gaps = 24/295 (8%)

Query: 120 LFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSL 179
           L KL AW  TGS S+ +    SL D    +I    I  ++Q AD +H +G+     ++ L
Sbjct: 30  LVKLIAWVMTGSASILATLTDSLMDVTTSIINLLAIKIALQPADDEHRFGHGKAESLAGL 89

Query: 180 ISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGA 239
                I    SG S Y    GI      H        +G  + S   T+++         
Sbjct: 90  AQAAFI----SGTSMYLMFNGISALVNGHQISATNVGIGVMIFSVIVTILL--------- 136

Query: 240 REANMSLYEYVMRSSDP-SVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILV 298
               ++   Y+++ +D  ++    L     +A        + ++ Y G    D + +I V
Sbjct: 137 ----VAFQSYIVKKTDSMAIRADSLHYRTDIAMNGAVLLALILAGY-GWYWADGVFAIAV 191

Query: 299 G-TILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDVK-GIDIGSNLI 356
              IL G      LS + AL+ + +P    ++I         +R +HD++  +   +  I
Sbjct: 192 SFYILHGAWQIGRLS-IDALMDKQLPKSDEEKIVKTAYHIKGVRGVHDLRTRLSGNTKFI 250

Query: 357 RYKAEVDFDGRALTRSYLEKHDLNALLE-DMKKIDTIDDVETFLLKHGENIVDML 410
           +   E+D D ++L  ++ +   L   LE D  + D +  ++   +   E + D L
Sbjct: 251 QLHLELD-DNQSLLEAHNKADQLEEALESDFPRADILIHLDPLSIVEEEKLNDKL 304


>UniRef50_A0AWY3 Cluster: Cation diffusion facilitator family
           transporter; n=14; Actinomycetales|Rep: Cation diffusion
           facilitator family transporter - Arthrobacter sp.
           (strain FB24)
          Length = 445

 Score = 45.6 bits (103), Expect = 0.003
 Identities = 53/250 (21%), Positives = 100/250 (40%), Gaps = 18/250 (7%)

Query: 87  SHTRSKDNVEEVGLKTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTV 146
           SH  S    + +   T   R +  ++ I     L +L    ++GS +L ++ IH+ +D +
Sbjct: 122 SHDASDSIDDALEASTEGIRALKISLFILLGTTLLQLIVVLFSGSVALLADTIHNFSDAL 181

Query: 147 NQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQP 206
             L L        + A   H YGY     ++ L   V +  + + ++ +  +  +  P P
Sbjct: 182 TALPLWVAFILGRRAASRRHTYGYGKSEDLAGLFI-VAVVALSAVVAAWQSIDRLFHPHP 240

Query: 207 LHDFYWAYFVLGGAVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDT 266
           L + +W   V+   +V       VA+  IR G +  + +L          +  V    D 
Sbjct: 241 LENLWW---VVAAGLVGFIGNEAVAVYRIRVGQKIGSAALV---------ADGVHARTDG 288

Query: 267 AAVAGVIVAASCMAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQ 326
                V+V A  + +     +P+   L S+ +  +L G      + ++G  +   I  E 
Sbjct: 289 FTSLAVVVGAGGVMLGFPLADPIVGLLISVAIIILLWGT-----VRSIGRRLMDGIEPEL 343

Query: 327 LDEINSVLER 336
           LD   + LER
Sbjct: 344 LDRAQTALER 353


>UniRef50_Q5ZR77 Cluster: Putative uncharacterized protein R02F11.3;
           n=3; Caenorhabditis|Rep: Putative uncharacterized
           protein R02F11.3 - Caenorhabditis elegans
          Length = 489

 Score = 45.6 bits (103), Expect = 0.003
 Identities = 73/331 (22%), Positives = 136/331 (41%), Gaps = 23/331 (6%)

Query: 72  VFTVKRRLRDYRRE-MSHTRSKD-NVEEV--GLKTRSGRVVLTAIGINGCNFLFKLCAWF 127
           +F V R  R+ R++ M  T +++ +V+E        + R+    + +N    + K+ A  
Sbjct: 155 IFDVPRSPRNPRKKPMERTDTEEKSVDEKKDDESNTAARMANITLAVNFLLMIAKVVASV 214

Query: 128 YTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD-HPYGYTNMRYVSSLISGVGIF 186
            +GS S+ S  + S+ D  + L+++    + ++  DP  +P G T +  +S ++  V I 
Sbjct: 215 LSGSMSIISSMVDSVVDITSGLVISLS-ERMIKKRDPYLYPRGRTRLEPLSLILISV-IM 272

Query: 187 CVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGAREANMSL 246
            + S       V GI D    H        L G        + +    I        +SL
Sbjct: 273 GMASIQLIIASVRGIHDGIQFH--------LYGIGEEPKLNVTITSVVIMVSTVLVKLSL 324

Query: 247 YEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGTILGGVA 306
           Y +  R  +PSVNV+ ++         VA  C  +         D  G+I+V   +    
Sbjct: 325 YLFCKRYKEPSVNVLAMDHRNDCISNTVALICAWLGTKYSYYF-DPAGAIVVSMYILYTW 383

Query: 307 SFIILSNVGALVGRSIPHEQLDEINSV-LERDFMIRAIHDVKGIDIGSNLIRYKAEVDFD 365
                 ++  L G++   E ++ I  V L+ D  I  I  V     GS  +  +  +  D
Sbjct: 384 VQTGREHLAKLSGKTAEPEFINRIIKVCLDHDARISHIDTVYVYHFGSKFL-VEVHIVLD 442

Query: 366 GRALTRSYLEKHDLNALLEDMKKIDTIDDVE 396
              + +   E HD++  L+    I+++ +VE
Sbjct: 443 ENMILK---ESHDISETLQ--SNIESLPEVE 468


>UniRef50_Q6MCR1 Cluster: Putative cation efflux system protein;
           n=1; Candidatus Protochlamydia amoebophila UWE25|Rep:
           Putative cation efflux system protein - Protochlamydia
           amoebophila (strain UWE25)
          Length = 313

 Score = 45.2 bits (102), Expect = 0.003
 Identities = 47/210 (22%), Positives = 92/210 (43%), Gaps = 20/210 (9%)

Query: 120 LFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSL 179
           +F+L       S +LF + I  L D ++ + L   I  + +  D DHP+G+     +  L
Sbjct: 41  VFELFGVALINSSTLFLDAISGLMDVLSTIFLIICIKLARKPPDEDHPFGHGRYEPLGGL 100

Query: 180 ISGVGIFCVGSGLSFYHGVTGILD--PQP-LHDFYWAYFVLGGAVVSEGATLMVALSAIR 236
           + G+ +  +G+ +  +  V G +   PQP LH   WA+     A++     L +    I 
Sbjct: 101 LIGLILIFIGA-IMLFQQVNGFIQEAPQPFLHP--WAWIFPATAMI----LLEICYQLIF 153

Query: 237 KGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSI 296
           + A+  N       + +      +  L    A   +I AA    + +++G  + D +G+I
Sbjct: 154 RTAKNENSP----ALAADAVHYRIDGLTSLLATLTLIAAA---LVPEWSG--IVDHIGAI 204

Query: 297 LVGTILGGVASFIILSNVGALVGRSIPHEQ 326
           L+   + G+  F    N   L  + +P+++
Sbjct: 205 LIALFMIGLGVFAARENFNQLTDK-VPNQE 233


>UniRef50_Q2AI61 Cluster: Cation efflux protein; n=1;
           Halothermothrix orenii H 168|Rep: Cation efflux protein
           - Halothermothrix orenii H 168
          Length = 292

 Score = 45.2 bits (102), Expect = 0.003
 Identities = 57/254 (22%), Positives = 108/254 (42%), Gaps = 23/254 (9%)

Query: 106 RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD 165
           +V   +I IN    + K+       S +L ++ +HS++D  + +++   I  S   AD  
Sbjct: 12  KVSFISIVINIILSVAKIFIGISFASKALLADGVHSVSDIASTVVVLISIKFSQNPADER 71

Query: 166 HPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEG 225
           HPYG+     + + +  +G+  + +GL+      G +             + G   V   
Sbjct: 72  HPYGHGKAEQIGTAL--LGLMLLITGLTLIKDTAGNM-------------ITGEITVPGQ 116

Query: 226 ATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDT---AAVAGVIVAASCMAIS 282
            TL +AL +I   ++EA   LY+Y ++      +  L+ D     + A   VAA      
Sbjct: 117 ITLWIALISII--SKEA---LYQYTVKIGKKINSKGLVADAHHHRSDALSSVAALAGIAG 171

Query: 283 QYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRA 342
              G P  D L  ++V  ++  ++  II   V  L+      +++ +I  + E    ++ 
Sbjct: 172 ARLGYPFLDPLAGLIVALLIIKISIEIIKEAVHELMDGIPDEDKIVKIRKIAENVSGVKD 231

Query: 343 IHDVKGIDIGSNLI 356
           I D+K    G +LI
Sbjct: 232 IGDIKIRSYGPHLI 245


>UniRef50_A0YFC6 Cluster: Cation transporter, cation diffusion
           facilitator (CDF) family protein; n=2;
           Gammaproteobacteria|Rep: Cation transporter, cation
           diffusion facilitator (CDF) family protein - marine
           gamma proteobacterium HTCC2143
          Length = 293

 Score = 45.2 bits (102), Expect = 0.003
 Identities = 22/65 (33%), Positives = 35/65 (53%)

Query: 106 RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD 165
           R++L    +N   F+ KL     TGS ++  + IHS+ D +N +I    +  S   AD +
Sbjct: 19  RILLIEGSVNLLVFVAKLIVGLTTGSLAILGDAIHSMTDVINNVIAWSVVRLSHAPADRE 78

Query: 166 HPYGY 170
           HPYG+
Sbjct: 79  HPYGH 83


>UniRef50_A0V364 Cluster: Cation diffusion facilitator family
           transporter precursor; n=1; Clostridium cellulolyticum
           H10|Rep: Cation diffusion facilitator family transporter
           precursor - Clostridium cellulolyticum H10
          Length = 285

 Score = 45.2 bits (102), Expect = 0.003
 Identities = 38/168 (22%), Positives = 76/168 (45%), Gaps = 9/168 (5%)

Query: 107 VVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDH 166
           V +  I  N      KL A F + S ++ ++  +S  D    ++   G   + +  D DH
Sbjct: 10  VAVFGIVANVFLLFIKLAAGFISRSQAMIADGFNSAGDVFASVMTLVGNSIASKPEDSDH 69

Query: 167 PYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGA 226
           PYG+    Y+ S+I  + +  V S   F   ++ I++      F  ++F++  A+++   
Sbjct: 70  PYGHGKAEYIFSMIISISLMFV-SFTIFKSSLSSIINKA---SFTVSWFLIATAIITIAI 125

Query: 227 TLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIV 274
            L + +   R G R  N+     V+ +S+   N V +  +  + G+I+
Sbjct: 126 KLSLFIYTSRIGKRMDNL----LVIANSEDHRNDVFV-TSGTILGIIM 168


>UniRef50_O27240 Cluster: Possible cation transporter; n=1;
           Methanothermobacter thermautotrophicus str. Delta H|Rep:
           Possible cation transporter - Methanobacterium
           thermoautotrophicum
          Length = 407

 Score = 45.2 bits (102), Expect = 0.003
 Identities = 31/120 (25%), Positives = 58/120 (48%), Gaps = 3/120 (2%)

Query: 127 FYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIF 186
           + +G+ +L ++ IHS AD  +   +  G+  S +  D   PYGY  +  + SL+  V I 
Sbjct: 35  YLSGNIALIADAIHSFADVFSSAAVFIGLKLSQRKPDELFPYGYHRIETLVSLLVSVLII 94

Query: 187 CVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGAREANMSL 246
             G  ++ +  +  IL+  P  +   A   L  +++S G +  +A   +R G R  + +L
Sbjct: 95  ITGLEIT-WDSIIYILN--PASEVSMATASLAVSLISIGVSYAIAFYKVRVGRRIGSTAL 151


>UniRef50_Q1AYG3 Cluster: Cation diffusion facilitator family
           transporter; n=1; Rubrobacter xylanophilus DSM 9941|Rep:
           Cation diffusion facilitator family transporter -
           Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
          Length = 314

 Score = 44.8 bits (101), Expect = 0.005
 Identities = 27/121 (22%), Positives = 55/121 (45%), Gaps = 1/121 (0%)

Query: 106 RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD 165
           R +  A+ I     + +    F TGS +L ++  H L+D  +  +  + +  S +   P+
Sbjct: 18  RSLAAALAITASYTVAEAVGGFLTGSLALLADAAHMLSDNFSLGLALFALWLSSRPPTPE 77

Query: 166 HPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEG 225
             +GY     +++L +GV +  V   + FY     +L+P+ +   + A     G +V+  
Sbjct: 78  RSFGYKRAEILAALFNGVTLVAVSLWI-FYEAYRRLLEPREVMGGWVAAVAAAGLLVNAA 136

Query: 226 A 226
           A
Sbjct: 137 A 137


>UniRef50_A1VZU0 Cluster: Cation efflux family protein; n=12;
           Campylobacter|Rep: Cation efflux family protein -
           Campylobacter jejuni subsp. jejuni serotype O:23/36
           (strain 81-176)
          Length = 295

 Score = 44.8 bits (101), Expect = 0.005
 Identities = 50/228 (21%), Positives = 101/228 (44%), Gaps = 16/228 (7%)

Query: 120 LFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSL 179
           L K      +GS ++ S  I SL D          + KS Q A+ ++ +G++ +  +  L
Sbjct: 20  LVKFIVGLTSGSVAVLSSAIDSLMDFAISAFNFLALKKSSQKANENYNFGFSKIEALMGL 79

Query: 180 ISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGA 239
           + GV I  VG  + FY  +  I   + + D   + +V+  A++     L++ L+ + K  
Sbjct: 80  LEGVFIVGVGIFI-FYESILKIYYKEEIKDLNSSIYVMIFALIMT-FFLVLFLNYVAKKT 137

Query: 240 REANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVG 299
           +   +   + +   +D   N       A   G +V      +  +T   + DA+  I++ 
Sbjct: 138 KSLIIE-SDALHYKTDCLTN-------ACTLGALV------LIYFTNLHIIDAIFGIVIS 183

Query: 300 TILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDVK 347
                 A  II   +  L+  ++P EQ+D+I +++  +  I + H++K
Sbjct: 184 LYTAFSAFKIIKKALAFLMDEALPKEQVDKICTLISNNPEIISYHELK 231


>UniRef50_P46348 Cluster: Uncharacterized transporter yeaB; n=19;
           Bacillales|Rep: Uncharacterized transporter yeaB -
           Bacillus subtilis
          Length = 290

 Score = 44.8 bits (101), Expect = 0.005
 Identities = 27/101 (26%), Positives = 48/101 (47%)

Query: 122 KLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLIS 181
           KL   +   S +L ++ +++  D +  + +  G+  S +  D DHPYG+     ++SLI+
Sbjct: 28  KLIIGYLFHSEALTADGLNNTTDIIASVAVLIGLRISQKPPDEDHPYGHFRAETIASLIA 87

Query: 182 GVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVV 222
              +  VG  + F  G +     Q   D   A+   GGAV+
Sbjct: 88  SFIMMVVGLQVLFSAGESIFSAKQETPDMIAAWTAAGGAVL 128


>UniRef50_Q62FW4 Cluster: Cation efflux family protein; n=48;
           Proteobacteria|Rep: Cation efflux family protein -
           Burkholderia mallei (Pseudomonas mallei)
          Length = 396

 Score = 44.4 bits (100), Expect = 0.006
 Identities = 37/144 (25%), Positives = 65/144 (45%), Gaps = 5/144 (3%)

Query: 131 SHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGS 190
           S +L ++ +HSL+D V+  ++      S    D DH YG++    V+S   G  +  VG 
Sbjct: 44  SQALIADGVHSLSDLVSDFVVLLANRHSGAKPDADHNYGHSRYETVASFFLGAILIAVGV 103

Query: 191 GLSFYHG--VTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGAREANMSLYE 248
           G+ +  G  +  + D  P+H    A  V+   ++S+       L   ++  R A +    
Sbjct: 104 GMLWRAGDRLVHLEDIPPVHASALAVAVV--VLLSKEGLFRYMLREAQR-VRSAMLVANA 160

Query: 249 YVMRSSDPSVNVVLLEDTAAVAGV 272
           +  RS   S  VV +    ++AGV
Sbjct: 161 WHARSDAASSLVVAIGIIGSLAGV 184


>UniRef50_Q3VS68 Cluster: Cation efflux protein; n=2;
           Chlorobiaceae|Rep: Cation efflux protein -
           Prosthecochloris aestuarii DSM 271
          Length = 319

 Score = 44.4 bits (100), Expect = 0.006
 Identities = 51/248 (20%), Positives = 99/248 (39%), Gaps = 21/248 (8%)

Query: 99  GLKTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKS 158
           G K + G  +  A+ + G  FL +L   + +GS +L ++  H   D     I    I  S
Sbjct: 33  GRKAKKG--LRFAVSVTGLIFLVELIGGWVSGSLALMADAGHMATDLFALSISYLAIRLS 90

Query: 159 VQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLG 218
            + +     YGY  +  +++LI+GV I C+ +          I  P+ +       F   
Sbjct: 91  ARPSTKKRSYGYFRIEIIAALINGV-ILCITALFITIEAWKRISLPKEIDSAQMLVF--- 146

Query: 219 GAVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASC 278
             ++   A +  A+   R+     N+            +  + +L D A   GV+  +  
Sbjct: 147 -GIIGLTANIASAIMLHREQKNSVNVK-----------AAYIHILSDLAGSVGVVAGSIL 194

Query: 279 MAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDF 338
           +++++ T     D++ S ++  ++   A  II   V  L+    P   + EI   L    
Sbjct: 195 ISLTRIT---TIDSIISFIIAILIVQSALKIIREAVDVLMESVPPELDIQEIEEALLNFR 251

Query: 339 MIRAIHDV 346
            +  +HD+
Sbjct: 252 HVEGLHDL 259


>UniRef50_A3XRG5 Cluster: Cobalt/zinc/cadmium cation efflux pump
           protein; n=7; Bacteria|Rep: Cobalt/zinc/cadmium cation
           efflux pump protein - Leeuwenhoekiella blandensis MED217
          Length = 304

 Score = 44.4 bits (100), Expect = 0.006
 Identities = 40/160 (25%), Positives = 77/160 (48%), Gaps = 8/160 (5%)

Query: 105 GRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADP 164
           GR +L +IG+N    L ++     +GS +L S+ +H+L+D ++ +I       S + A  
Sbjct: 18  GRNLLISIGLNVLITLAQIIGGLISGSLALLSDAVHNLSDVISLIISYIAQRYSKKEAST 77

Query: 165 DHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPL-HDFYWAYFVLGGAVVS 223
              +GY     +++ ++   +  + + L     V   L+PQ +  D      VLG  +V+
Sbjct: 78  HKTFGYKRAEIIAAFVNAATLIVI-AVLLMKEAVERFLNPQAIASDLVIWLAVLG--IVA 134

Query: 224 EGATLMVALSAIRKGAREANM-SLYEYVMRSSDPSVNVVL 262
            G ++++ L    KG    NM S Y +++     SV V++
Sbjct: 135 NGLSVLL-LQKDSKG--NMNMRSAYLHLLTDMMASVAVLV 171


>UniRef50_Q5D9U1 Cluster: SJCHGC08837 protein; n=1; Schistosoma
           japonicum|Rep: SJCHGC08837 protein - Schistosoma
           japonicum (Blood fluke)
          Length = 147

 Score = 44.4 bits (100), Expect = 0.006
 Identities = 19/41 (46%), Positives = 27/41 (65%)

Query: 1   MRAMTEYLLKQSDLESLPKVLRRSPYESEPPITVYYRRDVE 41
           +RA+ EY+L + DL+ LP+   RSPY +E    V+ R DVE
Sbjct: 105 LRALREYMLTKQDLDQLPRYYSRSPYGNETKTLVFLRSDVE 145


>UniRef50_Q8CNH2 Cluster: CzrB protein; n=3; Staphylococcus|Rep:
           CzrB protein - Staphylococcus epidermidis (strain ATCC
           12228)
          Length = 323

 Score = 44.0 bits (99), Expect = 0.008
 Identities = 53/244 (21%), Positives = 105/244 (43%), Gaps = 17/244 (6%)

Query: 102 TRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQM 161
           T + +V++ +  I     L ++   F   S +L S+  H L+D ++  +       + + 
Sbjct: 25  TDNKKVLMFSFIIISLFMLVEIIGGFLANSLALLSDGFHMLSDAISLGVALIAFIYAEKH 84

Query: 162 ADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAV 221
           A     YGY     +++L +GV +F + S +     +   L+P  +       F++  +V
Sbjct: 85  ATKSKTYGYKRFEILAALFNGVTLFII-SIIIIIEAIRRFLEPPEVQS--KEMFII--SV 139

Query: 222 VSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAI 281
           +     ++VA+   + G    N++     MR +   V    L D     G IVA+  +  
Sbjct: 140 IGLMVNIIVAILMFKGGDTSHNLN-----MRGAFLHV----LGDLFGSVGAIVASLLIWG 190

Query: 282 SQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIR 341
             +T   + D + SILV  I+   A  I  S++  L+  +     L+ +   + +D  I+
Sbjct: 191 FNFT---IADPIASILVSLIILKSAYGISKSSLNILMEGTPNDIDLNAVIKAISKDERIQ 247

Query: 342 AIHD 345
            +HD
Sbjct: 248 NVHD 251


>UniRef50_Q5FQH9 Cluster: Cation efflux system protein; n=1;
           Gluconobacter oxydans|Rep: Cation efflux system protein
           - Gluconobacter oxydans (Gluconobacter suboxydans)
          Length = 297

 Score = 44.0 bits (99), Expect = 0.008
 Identities = 22/87 (25%), Positives = 44/87 (50%)

Query: 106 RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD 165
           +V   +I ++      K  A+  +GS +L S+ I ++ + V  +   + +  +   AD +
Sbjct: 7   KVARASIVLSVVVLAIKYAAYVVSGSEALLSDAIETILNVVAAVGTLWAMSVAALPADDN 66

Query: 166 HPYGYTNMRYVSSLISGVGIFCVGSGL 192
           HPYG+    Y+S++I GV +     G+
Sbjct: 67  HPYGHGKAEYLSAVIEGVLVVLTAIGI 93


>UniRef50_Q2BMX3 Cluster: Cation-efflux family protein; n=1;
           Neptuniibacter caesariensis|Rep: Cation-efflux family
           protein - Neptuniibacter caesariensis
          Length = 393

 Score = 44.0 bits (99), Expect = 0.008
 Identities = 47/230 (20%), Positives = 99/230 (43%), Gaps = 20/230 (8%)

Query: 120 LFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSL 179
           + K+       S +L ++ +HSL+D ++ +++   +  S +  D +HP+G+     + + 
Sbjct: 27  IIKIFVGQVANSTALIADGVHSLSDLLSDILIVAILRISGKGPDREHPWGHGYFETIGTA 86

Query: 180 ISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYW-AYFVLGGAVVSEGATLMVALSAIRKG 238
           I G  +  V +G   Y G T +   + L    W A  V G +++ +       LS  +K 
Sbjct: 87  ILGCLLIAV-AGAMAYEGATQLFSHRELLSPEWPALLVAGISILGKEWIFRYTLSIGKK- 144

Query: 239 AREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILV 298
                          SD  +       T A++ +IV          +G    D+L ++ V
Sbjct: 145 -------------LKSDLLIANAWHSRTDALSSIIVFIG--VAGAMSGFEWLDSLATVAV 189

Query: 299 GTILGGVASFIILSNVGALVGRSIPHEQLDE-INSVLERDFMIRAIHDVK 347
             ++  +   +  S++  LV  ++P +++D+    +L  D ++  +HD K
Sbjct: 190 ALLIAKIGWDLSWSSLKQLVNTALPQDEIDKYCEQILAVDGVVN-VHDFK 238


>UniRef50_A6LZH5 Cluster: Cation diffusion facilitator family
           transporter; n=1; Clostridium beijerinckii NCIMB
           8052|Rep: Cation diffusion facilitator family
           transporter - Clostridium beijerinckii NCIMB 8052
          Length = 393

 Score = 44.0 bits (99), Expect = 0.008
 Identities = 17/76 (22%), Positives = 38/76 (50%)

Query: 114 INGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNM 173
           IN    + ++    +  S ++ ++  H+L D ++ L+  +    + + AD  HP+GY  +
Sbjct: 39  INSSILILEIVIGLFLNSIAITADAFHNLTDALSSLVTIFSFKLANRPADDKHPFGYGRI 98

Query: 174 RYVSSLISGVGIFCVG 189
            Y+++ +    I  VG
Sbjct: 99  EYITAFLFSCAILVVG 114


>UniRef50_A0LXC1 Cluster: CDF family cation efflux protein; n=3;
           Bacteria|Rep: CDF family cation efflux protein -
           Gramella forsetii (strain KT0803)
          Length = 295

 Score = 44.0 bits (99), Expect = 0.008
 Identities = 28/103 (27%), Positives = 48/103 (46%), Gaps = 1/103 (0%)

Query: 103 RSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMA 162
           +SG+ +  A  +N    + +     Y  S ++ S+ +H L D+++     Y   KS Q A
Sbjct: 9   QSGKNLKLAFFLNLAFTILEFIGGMYVNSIAIISDAVHDLGDSLSLGTSWYLDKKSKQGA 68

Query: 163 DPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQ 205
           +    +GY     + +LI+ V +   GS    Y  V  IL+PQ
Sbjct: 69  NAQFSFGYRRFSLLGALINSV-VLIAGSVYVIYEAVGRILEPQ 110


>UniRef50_Q81QV5 Cluster: Cation efflux family protein; n=19;
           Firmicutes|Rep: Cation efflux family protein - Bacillus
           anthracis
          Length = 296

 Score = 43.6 bits (98), Expect = 0.010
 Identities = 58/244 (23%), Positives = 106/244 (43%), Gaps = 21/244 (8%)

Query: 122 KLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLIS 181
           K+   + T S +L ++ +++L D    L +  G+  S +  DPDHPYG++    ++SL++
Sbjct: 30  KIIISYITLSSALRADGLNNLTDIGASLAILIGLKISRKPRDPDHPYGHSRAEQIASLVA 89

Query: 182 GVGIFCVGSGLSFYHGVTGILDP-QPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGAR 240
              +  VG  +     +   L+P Q   +   A+  L  AVV       V L   +  AR
Sbjct: 90  SFIMATVGLEV-VISAIQSFLNPKQAAPNVLAAWVALFSAVV----MYCVYLYTKKIAAR 144

Query: 241 EANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGT 300
             + SL E   + +        L D     G +V    +  SQ+   P+ D + +++VG 
Sbjct: 145 TKSKSL-EAAAKDN--------LSDALVSIGTVVG---IVGSQFQ-MPILDPIAALIVGL 191

Query: 301 ILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDVKGIDIGS-NLIRYK 359
           I+   A + I      ++   I  ++++E    +E    +  I D+K    G+   +   
Sbjct: 192 IICKTA-WEIFVEASHMLTDGIDPDKMEEYADAIEHIGGVENIVDIKARMYGNQTYVDIT 250

Query: 360 AEVD 363
            EVD
Sbjct: 251 IEVD 254


>UniRef50_A0LCE7 Cluster: Cation diffusion facilitator family
           transporter; n=1; Magnetococcus sp. MC-1|Rep: Cation
           diffusion facilitator family transporter - Magnetococcus
           sp. (strain MC-1)
          Length = 401

 Score = 43.6 bits (98), Expect = 0.010
 Identities = 68/301 (22%), Positives = 124/301 (41%), Gaps = 28/301 (9%)

Query: 103 RSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMA 162
           ++ R ++  + +N    + K+ A     S ++ ++ IHS +D ++   +  G+  + Q  
Sbjct: 16  QANRCLIVGVWVNLLLTIAKIIAGVVGNSAAMVADGIHSASDLISDGAVWLGMRVARQEP 75

Query: 163 DPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFV-LGGAV 221
           D +HPYG+     +++L   + +  V  G+     V   +D        W   V     V
Sbjct: 76  DEEHPYGHGRFETLATLFIALALAGVAIGI-----VADAVD-----RIQWGGNVGTPLPV 125

Query: 222 VSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDT---AAVAGVIVAASC 278
            ++ A + V +S   K A      L+ Y  R  +      L+ +     + A   VAA  
Sbjct: 126 PTDVALIAVVVSIFTKEA------LFHYTKRVGERLNQRALVANAWHHRSDAVSSVAAMV 179

Query: 279 MAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRS--IPHEQLDEINSVLER 336
             +    G P+ D + +++V  IL  VA   +L         S  +  +   +IN V+E 
Sbjct: 180 GIVGAQLGWPVMDPIAAVVVAAILFKVAYGFLLEVYREFTDASSAVDEKIQSQINQVIEN 239

Query: 337 DFMIRAIHDVKGIDIGSNLIRYKAEVDFDGRALTRSYLEKHDL--NALLEDMKKIDTIDD 394
              +R+ H VK    GS+ ++    V   G   T S  E H +     L  +K+I  + D
Sbjct: 240 HPDVRSAHLVKARRSGSD-VQVDIHVVVKG---TLSVSEGHQIAEQIRLHLLKEIMAVKD 295

Query: 395 V 395
           V
Sbjct: 296 V 296


>UniRef50_Q5KK51 Cluster: Di-, tri-valent inorganic cation
           transporter, putative; n=3; Basidiomycota|Rep: Di-,
           tri-valent inorganic cation transporter, putative -
           Cryptococcus neoformans (Filobasidiella neoformans)
          Length = 523

 Score = 43.6 bits (98), Expect = 0.010
 Identities = 25/93 (26%), Positives = 47/93 (50%), Gaps = 3/93 (3%)

Query: 102 TRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQM 161
           +R  R++ T + I+   FL +L   +  GS +L ++  H L D ++ ++  Y I  +   
Sbjct: 4   SRQARII-TLLVIDSVFFLIELITGYAVGSLALVADSFHMLNDVLSLIVALYTIRLATSP 62

Query: 162 ADPDHPYGYTNMRYVSSLISGVGI--FCVGSGL 192
           +   + YG+     + +LI+GV +   CV  GL
Sbjct: 63  SSSANSYGWQRAEILGALINGVFLVALCVSIGL 95


>UniRef50_Q8TT22 Cluster: Cation efflux system protein; n=5;
           cellular organisms|Rep: Cation efflux system protein -
           Methanosarcina acetivorans
          Length = 331

 Score = 43.6 bits (98), Expect = 0.010
 Identities = 58/269 (21%), Positives = 113/269 (42%), Gaps = 16/269 (5%)

Query: 121 FKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLI 180
           FK  A     S ++ ++ +HS +D +  + +  G+  + +  D  H YG+  +  +S+  
Sbjct: 43  FKFFAGIVGNSSAMIADAVHSTSDFMTDIAVIAGLKVAKKPGDSTHNYGHGKIETLSAAF 102

Query: 181 SGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGAR 240
            G+ +  V  G+ F+ G+  +L       FY    +   + V+  A   V   AI++   
Sbjct: 103 IGLVLIAVAFGI-FWSGLQKVL------AFYQGETLPAPSRVALAAA--VISIAIKEWLY 153

Query: 241 EANMSLYEYVMRSSDPSVNV-VLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVG 299
              M  Y   +RS   + N      D  +  G +V     AI       + D + ++++ 
Sbjct: 154 HYTMR-YALKLRSDALTANAWHHRSDAFSSIGTMVGIG-GAILLGGRWVVLDPIAAVILS 211

Query: 300 TILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDVKGIDIGSNLIRYK 359
             +  VA  I   N+  L+  S+  E    I  +L     +   H++K   IG N +   
Sbjct: 212 CFIFKVAFEISYKNLNELLEASLDSETYRSIEEILMSTEGVLGFHELKTRKIG-NAMAAD 270

Query: 360 AEVDFDGRALTRSYLEKHDLNALLEDMKK 388
             ++ D R L  + ++ H+++  +ED  K
Sbjct: 271 VHIEVD-RNL--NIVDAHEISTQVEDRLK 296


>UniRef50_Q98H85 Cluster: Cation efflux system protein; n=8;
           Alphaproteobacteria|Rep: Cation efflux system protein -
           Rhizobium loti (Mesorhizobium loti)
          Length = 365

 Score = 43.2 bits (97), Expect = 0.014
 Identities = 56/239 (23%), Positives = 106/239 (44%), Gaps = 22/239 (9%)

Query: 128 YTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFC 187
           +TGS +L ++  H LAD +   +  Y  H + + A     YG+  ++ + +  +G+ IF 
Sbjct: 87  FTGSLALLADAGHMLADAIALGLAWYAFHLAGRPATGQLTYGFGRVKTLVAYTNGIAIFV 146

Query: 188 VGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGAREANMSLY 247
           +   +  Y     +L P P+         + G +V+ G+ L+     +  G RE ++++ 
Sbjct: 147 IALWI-VYEAWQRLLTPAPVLGGPMLVVAILGLLVNIGSFLV-----LHGGDRE-SLNMR 199

Query: 248 EYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGTILGGVAS 307
             ++          +L D    A  IVAA  + ++ +T  P+ D + S+LV  ++   A 
Sbjct: 200 GAILH---------VLGDLLGSAAAIVAAVVILVTGWT--PI-DPILSVLVSLLILSTAW 247

Query: 308 FIILSNVGALVGRSIPHEQLDEINSVLERDFM-IRAIH--DVKGIDIGSNLIRYKAEVD 363
            ++ +    L+    P    D I + LE     +R +H   V  ID  SN+    A +D
Sbjct: 248 SLMRAAAHVLLEGVPPSLDRDLIATDLETTIQGVREVHHMHVWSIDGSSNMATLHACLD 306


>UniRef50_A6BIC1 Cluster: Putative uncharacterized protein; n=1;
           Dorea longicatena DSM 13814|Rep: Putative
           uncharacterized protein - Dorea longicatena DSM 13814
          Length = 369

 Score = 43.2 bits (97), Expect = 0.014
 Identities = 31/131 (23%), Positives = 58/131 (44%), Gaps = 3/131 (2%)

Query: 95  VEEVGLKTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYG 154
           ++E   + R  R  L  I +N      K+       S ++ SE I++  D  +  +   G
Sbjct: 1   MKESSRQERIIRTSLIGILVNLLIAAVKIVIGTLASSIAIVSEGINNATDAGSSFLTYVG 60

Query: 155 IHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFY-HGVTGILDPQPLHDFYWA 213
              S +  D  HP+GY  + Y++ ++  VGI  + +G+S     + GIL P  +      
Sbjct: 61  TKLSGKHPDEKHPFGYGRIEYLTGMV--VGILILYAGISMLKESIDGILHPSDMKVSMLM 118

Query: 214 YFVLGGAVVSE 224
             ++ G  V++
Sbjct: 119 VLIVAGTAVTK 129


>UniRef50_Q8TT88 Cluster: Cation efflux system protein; n=4;
           Methanosarcinaceae|Rep: Cation efflux system protein -
           Methanosarcina acetivorans
          Length = 311

 Score = 43.2 bits (97), Expect = 0.014
 Identities = 23/84 (27%), Positives = 44/84 (52%)

Query: 106 RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD 165
           +V++  + +N      K+    +TG+ S+ ++  HSL D V+ ++   GI+ S +  D D
Sbjct: 25  QVLVLVLFLNLAVAFAKIIYGTFTGTLSMTADGYHSLFDGVSNIVGLVGIYISSRPPDRD 84

Query: 166 HPYGYTNMRYVSSLISGVGIFCVG 189
           HPYG+      +S+   + +  VG
Sbjct: 85  HPYGHQKYETFASIFIAILLLFVG 108


>UniRef50_Q97PQ1 Cluster: Cation efflux family protein; n=41;
           Streptococcus|Rep: Cation efflux family protein -
           Streptococcus pneumoniae
          Length = 394

 Score = 42.7 bits (96), Expect = 0.018
 Identities = 22/68 (32%), Positives = 39/68 (57%)

Query: 122 KLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLIS 181
           KL A     S SL ++  ++++D +  + L  GI  + Q AD DH +G+  +  ++SLI+
Sbjct: 29  KLAAGHLLHSSSLVADGFNNVSDIIGNVALLIGIRMARQPADRDHRFGHWKIEDLASLIT 88

Query: 182 GVGIFCVG 189
            + +F VG
Sbjct: 89  SIIMFYVG 96


>UniRef50_Q7UMH1 Cluster: Cation efflux system protein; n=1;
           Pirellula sp.|Rep: Cation efflux system protein -
           Rhodopirellula baltica
          Length = 331

 Score = 42.7 bits (96), Expect = 0.018
 Identities = 40/163 (24%), Positives = 74/163 (45%), Gaps = 8/163 (4%)

Query: 108 VLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQM-ADPDH 166
           +L ++ +N    + ++ A   +GS +L S+  H+ +D  N L++AY   +  +  A+  +
Sbjct: 41  LLWSVLLNQALTVAQVIAGILSGSVALLSDAAHNFSD-ANSLLIAYIARRIARKEANQRY 99

Query: 167 PYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGA 226
            +GY     + + I+   +  VG  L  Y  V    DPQP+  +  A       VV  G 
Sbjct: 100 TFGYRRAELIGATINLTLLAVVGCYL-VYEAVHRFFDPQPIIGWLMAVTAAVALVVDLGT 158

Query: 227 TLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAV 269
             +  L A+ KG+     +   ++    D + +V +L   AAV
Sbjct: 159 AFL--LWAMSKGSLNVRAA---FIHNLVDAAGSVAVLIGAAAV 196


>UniRef50_Q74FW5 Cluster: Cation efflux family protein; n=7;
           Desulfuromonadales|Rep: Cation efflux family protein -
           Geobacter sulfurreducens
          Length = 331

 Score = 42.7 bits (96), Expect = 0.018
 Identities = 53/254 (20%), Positives = 109/254 (42%), Gaps = 21/254 (8%)

Query: 111 AIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGY 170
           AI +     + ++    +T S +L S+  H   D    ++    I  +   A     +G+
Sbjct: 18  AIALTALTLVAEIVGGIWTNSLALLSDAAHVFLDLFALVLSLAAIKLASYPASDTKTFGW 77

Query: 171 TNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMV 230
                 +S I+G  +F +  G+ FY  V  +++P+ +           G V++     ++
Sbjct: 78  HRAEVFASFINGATVFLMALGI-FYEAVGRLMNPEAVKSLPMLLIATLGLVMN-----LI 131

Query: 231 ALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLP 290
           + +A+   + +      +  +RS+   ++VV   D AA  GVIV      I  +TG  + 
Sbjct: 132 SATALHGHSHD------DLNVRSA--FLHVV--GDAAASVGVIVGG---LIMYFTGWYVL 178

Query: 291 DALGSILVGTILGGVASFIILSNVGALVGRSIPH-EQLDEINSVLERDFMIRAIHDVKGI 349
           DAL SI +G ++    S+ +L     ++   +P      ++ + +     + A+H +   
Sbjct: 179 DALISIGIGCVI-FAGSWRVLREAAHILLEGVPRGMSTQQVANEMAGVEGVNAVHQMNIW 237

Query: 350 DIGSNLIRYKAEVD 363
            I S+++   A VD
Sbjct: 238 TICSHILALSAHVD 251


>UniRef50_A6LME7 Cluster: Cation diffusion facilitator family
           transporter; n=1; Thermosipho melanesiensis BI429|Rep:
           Cation diffusion facilitator family transporter -
           Thermosipho melanesiensis BI429
          Length = 294

 Score = 42.7 bits (96), Expect = 0.018
 Identities = 54/241 (22%), Positives = 105/241 (43%), Gaps = 23/241 (9%)

Query: 129 TGSHSLFSECIHSLADTVNQLILAYGIHK-SVQMADPDHPYGYTNMRYVSSLISGVGIFC 187
           +GS +L S+ +H+L+DT   L+++Y   K S +  D  + YGY     V+S+I+   +  
Sbjct: 36  SGSLALISDALHNLSDT-GALLISYFARKISKKPVDNKYTYGYKRAELVASVINITVLLS 94

Query: 188 VGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGAREANMSLY 247
           +   L    G+  IL P  ++       +L  A V     L+ A+  +     + N++L 
Sbjct: 95  ISFSL-ILEGIKKILSPVQIN----TSIMLIVAYVGLVGNLLTAI--LLSSHSKENLNL- 146

Query: 248 EYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGTILGGVAS 307
                    S  + +L D  +  G+I+    M  S Y    L   +  ++ G I+  + S
Sbjct: 147 --------KSAFLHILSDMFSSVGIIITGHVM--SYYNIWILDPIITFVISGYII--IES 194

Query: 308 FIILSNVGALVGRSIPH-EQLDEINSVLERDFMIRAIHDVKGIDIGSNLIRYKAEVDFDG 366
             IL     +V + IP    LD++  +++    ++ +H +    +    +  +  V  DG
Sbjct: 195 IKILKESIRVVMQGIPKGVDLDKVKKIIQNFSFVKDVHHIHVWSLDGIELYLEMHVTVDG 254

Query: 367 R 367
           +
Sbjct: 255 K 255


>UniRef50_A0LLF0 Cluster: Cation diffusion facilitator family
           transporter precursor; n=1; Syntrophobacter fumaroxidans
           MPOB|Rep: Cation diffusion facilitator family
           transporter precursor - Syntrophobacter fumaroxidans
           (strain DSM 10017 / MPOB)
          Length = 310

 Score = 42.7 bits (96), Expect = 0.018
 Identities = 25/105 (23%), Positives = 44/105 (41%), Gaps = 1/105 (0%)

Query: 103 RSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMA 162
           +  R  + ++  N      K+    Y GS S+ SE IHS  D +   I    +  S +  
Sbjct: 7   KKSRAAMISVLSNATLVALKIVVGVYIGSVSVISEAIHSGVDLLAAAIAYLAVRTSGRPP 66

Query: 163 DPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPL 207
           D  HP+G+     +S  +  + IF   + +     V  +  P+P+
Sbjct: 67  DRKHPFGHGKFENISGTVEALLIFLAAAWI-VRESVQKLRHPEPI 110


>UniRef50_A7I5F3 Cluster: Cation diffusion facilitator family
           transporter; n=1; Candidatus Methanoregula boonei
           6A8|Rep: Cation diffusion facilitator family transporter
           - Methanoregula boonei (strain 6A8)
          Length = 328

 Score = 42.7 bits (96), Expect = 0.018
 Identities = 23/76 (30%), Positives = 35/76 (46%)

Query: 111 AIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGY 170
           ++  N    + K    F  GS S+ SE IHS  D +  +I  + + KS +  D  H +G+
Sbjct: 22  SVASNTILVILKFAVGFGIGSVSIISEAIHSSMDLIAAVIAFFSVKKSAEPPDHVHEFGH 81

Query: 171 TNMRYVSSLISGVGIF 186
                 S LI  + IF
Sbjct: 82  GKFEDASGLIEALLIF 97


>UniRef50_Q67QQ7 Cluster: Cation efflux system protein; n=1;
           Symbiobacterium thermophilum|Rep: Cation efflux system
           protein - Symbiobacterium thermophilum
          Length = 329

 Score = 42.3 bits (95), Expect = 0.024
 Identities = 61/262 (23%), Positives = 108/262 (41%), Gaps = 25/262 (9%)

Query: 106 RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD 165
           R  L  I +N C  + +  A F  GS ++ ++  +S  D +  L++  G   + +  D +
Sbjct: 16  RAGLLTIAVNLCLTVARAAAGFLAGSTAVLADAANSGTDILATLVVMGGSRIAARPPDWN 75

Query: 166 HPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEG 225
           HPYG+     V++ +  VGI    +GL+   G    L               GG  V   
Sbjct: 76  HPYGHDKAEPVAAKL--VGILVTFAGLATAAGAVQALR-------------AGGEPVGLA 120

Query: 226 ATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTA-AVAGVIVAASCM--AIS 282
           A ++ A+S     A+EA   L  Y+ R      +  +L D A     V+ +A+ +  A+ 
Sbjct: 121 AAVVTAVSI---AAKEA---LARYLARLGRRLRSQAVLADAANQRTDVLASATALAGALG 174

Query: 283 QYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRA 342
              G P+ D L  +LV  ++  +   +    V  L+ R+   E +D +         +R 
Sbjct: 175 GRFGLPILDPLMGLLVSALILRMGLGLYWQAVRDLMDRAPEPETVDAMRRAALSVPGVRE 234

Query: 343 IHDVKGIDIGSNL-IRYKAEVD 363
           + D++    G  +    K  VD
Sbjct: 235 VGDLRARVFGPGIYAECKVSVD 256


>UniRef50_A1VD81 Cluster: Cation diffusion facilitator family
           transporter; n=3; Bacteria|Rep: Cation diffusion
           facilitator family transporter - Desulfovibrio vulgaris
           subsp. vulgaris (strain DP4)
          Length = 481

 Score = 42.3 bits (95), Expect = 0.024
 Identities = 20/59 (33%), Positives = 32/59 (54%)

Query: 122 KLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLI 180
           KL   F T S  + SE  HS  D V  ++  + +  + + AD DHPYG+  +  +S+L+
Sbjct: 33  KLGVGFATNSLGILSEAAHSGLDLVAAVVTYWAVRAASRPADADHPYGHGKVENLSALV 91


>UniRef50_Q03218 Cluster: Mitochondrial metal transporter 1,
           mitochondrial precursor; n=3; Saccharomycetales|Rep:
           Mitochondrial metal transporter 1, mitochondrial
           precursor - Saccharomyces cerevisiae (Baker's yeast)
          Length = 510

 Score = 42.3 bits (95), Expect = 0.024
 Identities = 21/79 (26%), Positives = 37/79 (46%)

Query: 101 KTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQ 160
           K    R+    +G+N    + K        S +LF++ IH+++D V+ L+    +  +  
Sbjct: 157 KNAGVRITWVGLGVNVGIAIGKFFGGIVFHSQALFADAIHAISDMVSDLLTLLSVGLAAN 216

Query: 161 MADPDHPYGYTNMRYVSSL 179
               D+PYGY  +  V SL
Sbjct: 217 KPTADYPYGYGKIETVGSL 235


>UniRef50_A7CNS8 Cluster: Cation diffusion facilitator family
           transporter; n=1; Opitutaceae bacterium TAV2|Rep: Cation
           diffusion facilitator family transporter - Opitutaceae
           bacterium TAV2
          Length = 294

 Score = 41.9 bits (94), Expect = 0.032
 Identities = 17/64 (26%), Positives = 35/64 (54%)

Query: 131 SHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGS 190
           S++L ++ I S+ D V  +++   +  S +  D DHPYG+     + +L S + +   G+
Sbjct: 19  SYALIADGIESINDIVASVVVLISLKVSSKPPDEDHPYGHGKAEQLGALFSAISLLAAGA 78

Query: 191 GLSF 194
            ++F
Sbjct: 79  TIAF 82


>UniRef50_A7BVM0 Cluster: Cation efflux protein; n=3; Beggiatoa sp.
           PS|Rep: Cation efflux protein - Beggiatoa sp. PS
          Length = 451

 Score = 41.9 bits (94), Expect = 0.032
 Identities = 22/88 (25%), Positives = 41/88 (46%), Gaps = 1/88 (1%)

Query: 120 LFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSL 179
           +FK+       S +L ++  HSL+  ++  ++      S +  D  HPYGY     ++++
Sbjct: 71  IFKIVFGIIGQSQALIADGFHSLSSLISDFVVLIAAQFSTKPPDVRHPYGYARYETLATI 130

Query: 180 ISGVGIFCVGSGLSFYHGVTGILDPQPL 207
             G+ +     GL      TG+L P+ L
Sbjct: 131 TIGILLLITAVGL-LIKAQTGLLAPELL 157


>UniRef50_A4BEK1 Cluster: Predicted Co/Zn/Cd cation transporter;
           n=1; Reinekea sp. MED297|Rep: Predicted Co/Zn/Cd cation
           transporter - Reinekea sp. MED297
          Length = 387

 Score = 41.9 bits (94), Expect = 0.032
 Identities = 41/158 (25%), Positives = 66/158 (41%), Gaps = 14/158 (8%)

Query: 120 LFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSL 179
           + KL   F   S  L ++  HSL+D    ++     + + Q  D DHPYG+     V + 
Sbjct: 30  ILKLGVGFAIRSPGLIADGFHSLSDLATDILALLLGNVASQGPDQDHPYGHARYETVGTA 89

Query: 180 ISGVGIFCVGSGLSFYHGVTGILD---PQPLHDFYWAYFVLGGAVVSEGATLMVALSAIR 236
           + G  +  V  G++    +  +L    P P    +W   +   AV+   A+         
Sbjct: 90  VLGTVLILVAGGIAI-ESIQALLSGHFPVP----HWTAVI---AVLISIASKEALFQYTH 141

Query: 237 KGAREANMSLYE---YVMRSSDPSVNVVLLEDTAAVAG 271
           + A+E N +L E   +  RS   S  VVL+   A  AG
Sbjct: 142 RKAKETNSALLEANAWHSRSDSLSSIVVLVGLIAGFAG 179


>UniRef50_Q97NZ2 Cluster: Cation efflux system protein; n=27;
           Streptococcus|Rep: Cation efflux system protein -
           Streptococcus pneumoniae
          Length = 299

 Score = 41.5 bits (93), Expect = 0.042
 Identities = 25/80 (31%), Positives = 40/80 (50%), Gaps = 1/80 (1%)

Query: 130 GSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVG 189
           GS ++ ++ +H L D +   I A+    S +  D  +  GY     + +L++ V I   G
Sbjct: 32  GSSAVLADSVHDLGDAIAIGISAFLETISNREEDNQYTLGYKRFSLLGALVTAV-ILVTG 90

Query: 190 SGLSFYHGVTGILDPQPLHD 209
           S L     VT IL PQP++D
Sbjct: 91  SVLVILENVTKILHPQPVND 110


>UniRef50_A0Y777 Cluster: Putative transport protein; n=3;
           Alteromonadales|Rep: Putative transport protein -
           Alteromonadales bacterium TW-7
          Length = 305

 Score = 41.5 bits (93), Expect = 0.042
 Identities = 58/264 (21%), Positives = 107/264 (40%), Gaps = 21/264 (7%)

Query: 122 KLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLIS 181
           K  AW  +GS S+      SL D     +    +  +++ AD DH +G+     ++ L  
Sbjct: 28  KAWAWLASGSASMLGSLTDSLMDITATFMSFLVLGYALRPADDDHRFGHGKAEALAGL-- 85

Query: 182 GVGIFCVGSG-LSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGAR 240
           G   F  GSG L  +HGV  + +P  L       +V   A+      + V    I+    
Sbjct: 86  GQAAFIAGSGCLLAFHGVERLFNPIELTHSLLGVWVSAFAIACTLVIVFVQTKVIKH--- 142

Query: 241 EANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGT 300
                  E +   +D   +V    D    A V++A   +A+S Y G    D + +I V  
Sbjct: 143 ------TESIAIKAD---SVHYKGDLILNAAVLIA---IALSYY-GMMYADPIFAIGVAG 189

Query: 301 ILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDVKGIDIGS-NLIRYK 359
            L   +  I   +   L+ + +P ++   I  + +    +  +H ++    G    I+  
Sbjct: 190 YLLYNSWDIARDSADHLMDKELPDDEKQSIFDIAKEHSDVHGVHGIRTRQGGKIKFIQMH 249

Query: 360 AEVDFDGRALTRSYLEKHDLNALL 383
            E+D D  +L R++    ++ A++
Sbjct: 250 LELD-DHLSLIRAHTVADEVEAMI 272


>UniRef50_A0L9V8 Cluster: Cation diffusion facilitator family
           transporter; n=1; Magnetococcus sp. MC-1|Rep: Cation
           diffusion facilitator family transporter - Magnetococcus
           sp. (strain MC-1)
          Length = 294

 Score = 41.5 bits (93), Expect = 0.042
 Identities = 46/228 (20%), Positives = 98/228 (42%), Gaps = 19/228 (8%)

Query: 129 TGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCV 188
           +G  +L ++  HS AD +   +    +  S + AD DH YG+  ++++SS I G+ I   
Sbjct: 35  SGCQALVADAFHSSADVMASTVTLASLKISERPADDDHHYGHGKVQFISSSIVGL-ILIT 93

Query: 189 GSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVAL-SAIRKGAREANMSLY 247
           G+       +  I+     +D      +LG A+      LM    S + K          
Sbjct: 94  GAIFILIDAIKTIVTGD--YDAPNRIAILGAAISVISNELMFRYQSCVGK---------- 141

Query: 248 EYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGTILGGVAS 307
               +++ P++     ++ +     I     +A + + G P+ D L ++ V  ++  +  
Sbjct: 142 ----QNNSPAIMANAWDNRSDAFSSIAVMIGVAFATF-GFPVADPLAALGVSVLVIRIGI 196

Query: 308 FIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDVKGIDIGSNL 355
            + L  +  L+  S   E+L++I  +++    +  I+ ++   +G NL
Sbjct: 197 ELNLEAIDGLMDASPEMEELEDIYKIVKDVSSVHGINYMRARTMGDNL 244


>UniRef50_Q8ZYX3 Cluster: Cation efflux system protein, conjectural;
           n=4; Pyrobaculum|Rep: Cation efflux system protein,
           conjectural - Pyrobaculum aerophilum
          Length = 319

 Score = 41.5 bits (93), Expect = 0.042
 Identities = 33/152 (21%), Positives = 69/152 (45%), Gaps = 4/152 (2%)

Query: 120 LFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSL 179
           L K+ AW  + S ++ ++ +HS  D +   I    +  S++  D +HPYG+     +  +
Sbjct: 19  LLKIVAWSQSFSVAVLADAVHSAVDLLAVTITYLAVKASLKPPDREHPYGHHKAETLGGI 78

Query: 180 ISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGA 239
              + +   G+ +S Y  V  ++  +P         ++  A+V +   ++V L   R  +
Sbjct: 79  GGSLAVMASGAFIS-YEAVMKLIHWEPFAPTALGIAIVALAIVIDFNRVLV-LRRFRGVS 136

Query: 240 R--EANMSLYEYVMRSSDPSVNVVLLEDTAAV 269
           R  EA+   +   + SS   + V++    +AV
Sbjct: 137 RALEADALHFSTDLASSSAILAVLIFGAFSAV 168


>UniRef50_Q97MV4 Cluster: Predicted Co/Zn/Cd cation transporter;
           n=1; Clostridium acetobutylicum|Rep: Predicted Co/Zn/Cd
           cation transporter - Clostridium acetobutylicum
          Length = 292

 Score = 41.1 bits (92), Expect = 0.056
 Identities = 26/107 (24%), Positives = 54/107 (50%), Gaps = 4/107 (3%)

Query: 92  KDNVEEVGLKTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLIL 151
           +DN + + +  R  R+ L    +     +FK    ++  S +L ++ I+S  D +  + +
Sbjct: 2   EDNYKNLKIAERGVRISLIIYVVLS---IFKFFMGYFFKSEALKADGINSSTDIIAAIAI 58

Query: 152 AYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGV 198
             G+  + + AD +H YG+     +SSL++ + +  VG  +  Y+GV
Sbjct: 59  IVGLKIARKPADKEHTYGHLRAETISSLLASLIMIAVGVDV-VYNGV 104


>UniRef50_A1IAH4 Cluster: Cation diffusion facilitator family
           transporter; n=1; Candidatus Desulfococcus oleovorans
           Hxd3|Rep: Cation diffusion facilitator family
           transporter - Candidatus Desulfococcus oleovorans Hxd3
          Length = 320

 Score = 41.1 bits (92), Expect = 0.056
 Identities = 22/88 (25%), Positives = 42/88 (47%), Gaps = 4/88 (4%)

Query: 112 IGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYT 171
           IG+ G  F+      F   S ++ ++ +HSL+D    + +  G+       D  HPYG+ 
Sbjct: 47  IGLAGLKFV----VGFLGASQAVIADAVHSLSDMTTDIAVLVGVKFWSAPPDTCHPYGHK 102

Query: 172 NMRYVSSLISGVGIFCVGSGLSFYHGVT 199
            +  + ++  G+ +  V  GL++   VT
Sbjct: 103 RVEALVTIFIGITLAAVACGLAYRAMVT 130


>UniRef50_Q8F433 Cluster: Cobalt-zinc-cadmium resistance protein
           czcD; n=4; Leptospira|Rep: Cobalt-zinc-cadmium
           resistance protein czcD - Leptospira interrogans
          Length = 317

 Score = 40.7 bits (91), Expect = 0.074
 Identities = 47/204 (23%), Positives = 89/204 (43%), Gaps = 21/204 (10%)

Query: 96  EEVGLKTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGI 155
           +E GLK    R +L AI ++   F  +L   F +GS +L ++  H + DT+   +    +
Sbjct: 15  QEKGLK----RSILLAILVSISIFFVELFGGFQSGSIALLADAGHIITDTIALSLSLIAV 70

Query: 156 HKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYF 215
             S +  +    +GY  +  ++SL++ + IF + S   FY  +    + + +  F   ++
Sbjct: 71  LLSSKKPNYRFSFGYYRIEILTSLLNSILIFGI-SFYIFYESIERFQNQKEILSFQMIFY 129

Query: 216 VLGGAVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVA 275
              G + +    L+ A    R      N+            S  V +L D  +  GV+V 
Sbjct: 130 SSFGIIFN----LISAWILFRFSGENINIK-----------SAYVHVLSDLLSTVGVLVG 174

Query: 276 ASCMAISQYTG-NPLPDALGSILV 298
           +  + I+ +   +PL   L SIL+
Sbjct: 175 SILIYITNWNWIDPLISVLISILI 198


>UniRef50_A5IIQ7 Cluster: Cation diffusion facilitator family
           transporter; n=2; Thermotoga|Rep: Cation diffusion
           facilitator family transporter - Thermotoga petrophila
           RKU-1
          Length = 306

 Score = 40.7 bits (91), Expect = 0.074
 Identities = 62/290 (21%), Positives = 123/290 (42%), Gaps = 25/290 (8%)

Query: 112 IGINGCNFL--FKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYG 169
           IGI G   L   K+     TGS+++ ++ I +  D     ++      S +  D  HPYG
Sbjct: 13  IGILGNTVLAVLKILVGLLTGSYAILADGIDTSTDIFTSFVILLSSRISGKPPDETHPYG 72

Query: 170 YTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLM 229
           +     ++S I    +F  G+ L     V  ++  +   +     F++ G  V+ G T +
Sbjct: 73  HERAETIASKIISFVMFYAGASL-LVESVKRLVKQEFSLELTLTAFIVVGISVA-GKTFL 130

Query: 230 VALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPL 289
             L  +  G R          ++SS    + + + +   ++G ++A   M   +  G   
Sbjct: 131 F-LYKLSLGKR----------LKSSATISDALNMRNDIMISGTVLAG--MVAMKTFGWWW 177

Query: 290 PDALGSILVGTILGGVASFIILSNVGALVG--RSIPHEQLDEINSVLERDFMIRAIHDVK 347
            D+L +I V  ++   +  +       L+   +    +  D+I +VLER   +   H V+
Sbjct: 178 LDSLLAIFVSIMILRTSFSVFYEAAYELMDGMKRTELDMYDDIFAVLERFPNVHNPHRVR 237

Query: 348 GIDIGSNLIRYKAEVDFDGRALTRSYLEKHDLNALL--EDMKKIDTIDDV 395
              +G+     + +++ DG+    S  + H+L   +  E +K+ D I+DV
Sbjct: 238 IRKVGTRHF-IEMDIEVDGK---MSVKDAHELTVKIRKEMLKRRDDIEDV 283


>UniRef50_A0Q5V4 Cluster: Predicted Co/Zn/Cd cation transporter;
           n=11; Francisella tularensis|Rep: Predicted Co/Zn/Cd
           cation transporter - Francisella tularensis subsp.
           novicida (strain U112)
          Length = 379

 Score = 40.7 bits (91), Expect = 0.074
 Identities = 22/97 (22%), Positives = 48/97 (49%), Gaps = 1/97 (1%)

Query: 106 RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD 165
           +V L  + IN    + K        S +LF++ IHS +D ++  ++ +    + +  D +
Sbjct: 11  KVTLVGMFINALLAISKTLIGVIGRSPALFADGIHSFSDLLSDFMVLFAAKYANKGEDHN 70

Query: 166 HPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGIL 202
           HPYG+  +  +++L+    +  +G  +  YH +  +L
Sbjct: 71  HPYGHERLETLATLVLSGLLITIGF-MIVYHSLVSLL 106


>UniRef50_A7SP61 Cluster: Predicted protein; n=1; Nematostella
          vectensis|Rep: Predicted protein - Nematostella
          vectensis
          Length = 185

 Score = 40.7 bits (91), Expect = 0.074
 Identities = 18/49 (36%), Positives = 31/49 (63%), Gaps = 1/49 (2%)

Query: 3  AMTEYLLKQSDLESLPKVLRRSPY-ESEPPITVYYRRDVEAKAIEIWGS 50
          A  +YLL   DL+ L    + +P  +S PP+ ++   +V++KA+E+WGS
Sbjct: 18 AKRDYLLSDEDLKELNHETKDNPINKSYPPMKIFKLSEVKSKAVEVWGS 66


>UniRef50_Q9PF12 Cluster: Cobalt-zinc-cadmium resistance protein;
           n=26; Proteobacteria|Rep: Cobalt-zinc-cadmium resistance
           protein - Xylella fastidiosa
          Length = 321

 Score = 40.3 bits (90), Expect = 0.097
 Identities = 24/97 (24%), Positives = 43/97 (44%), Gaps = 1/97 (1%)

Query: 111 AIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGY 170
           A+G+     + ++     T S +L S+ +H   D    +I    +  S +  D    YGY
Sbjct: 42  ALGLTASFLVAEIIGAVLTRSLALLSDAVHMATDVFALMIALVAVRLSRRPPDVRRTYGY 101

Query: 171 TNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPL 207
             +    +L++GV +F VG G   +  V  +  PQ +
Sbjct: 102 ARLEAFGALVNGVLLFGVG-GYILWEAVQRLRAPQEI 137


>UniRef50_Q6AS02 Cluster: Conserved hypothetical membrane protein;
           n=1; Desulfotalea psychrophila|Rep: Conserved
           hypothetical membrane protein - Desulfotalea
           psychrophila
          Length = 345

 Score = 40.3 bits (90), Expect = 0.097
 Identities = 28/127 (22%), Positives = 56/127 (44%), Gaps = 4/127 (3%)

Query: 96  EEVGLKTRSGRVVLTAIGINGCNFLF--KLCAWFYTGSHSLFSECIHSLADTVNQLILAY 153
           E++G  ++  RV    + +    F+   K  A+  + S ++FS+   S  + V  L+   
Sbjct: 13  EKIGQDSKD-RVKAARVSLVASFFIMCCKFAAFIVSDSQAIFSDAAESTVNVVAALLALI 71

Query: 154 GIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWA 213
            I  +++ AD  HPYG+  M + S+   G G+    +       V  +   Q + +  + 
Sbjct: 72  IITMAMKPADDRHPYGHGKMEFFSAAFEG-GLITFAALAILVKAVNALFYGQEIKELGYG 130

Query: 214 YFVLGGA 220
             ++G A
Sbjct: 131 LLLIGFA 137


>UniRef50_A3ERL9 Cluster: Putative Co/Zn/Cd cation transporter; n=1;
           Leptospirillum sp. Group II UBA|Rep: Putative Co/Zn/Cd
           cation transporter - Leptospirillum sp. Group II UBA
          Length = 302

 Score = 40.3 bits (90), Expect = 0.097
 Identities = 25/91 (27%), Positives = 48/91 (52%), Gaps = 3/91 (3%)

Query: 100 LKTRSGRVVLTAIGINGCNFLFKLCAWFYT-GSHSLFSECIHSLADTVNQLILAYGIHKS 158
           L+T +G + L A+ IN    + K+  W ++  S  + ++  H+L D+V+ LI   G+  +
Sbjct: 8   LRTPAGTLTL-ALTINTFLSILKI-GWGHSIHSAGMIADGYHALLDSVSDLICLVGVSMA 65

Query: 159 VQMADPDHPYGYTNMRYVSSLISGVGIFCVG 189
            +  D +HPYG+     ++ +   V +F  G
Sbjct: 66  NRPPDENHPYGHGKFEPLAQVAVSVFLFLTG 96


>UniRef50_A0L9W4 Cluster: Cation diffusion facilitator family
           transporter; n=1; Magnetococcus sp. MC-1|Rep: Cation
           diffusion facilitator family transporter - Magnetococcus
           sp. (strain MC-1)
          Length = 332

 Score = 40.3 bits (90), Expect = 0.097
 Identities = 15/59 (25%), Positives = 33/59 (55%)

Query: 122 KLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLI 180
           K+     +GSH+L ++ ++S  D +   ++  G+  S +  D  HP+G+  + ++ SL+
Sbjct: 28  KIFVGIISGSHALLADALYSSKDVITSALIIVGLKVSNKPIDEKHPFGHGKIEFLLSLV 86


>UniRef50_A6UWS0 Cluster: Cation diffusion facilitator family
           transporter; n=1; Methanococcus aeolicus Nankai-3|Rep:
           Cation diffusion facilitator family transporter -
           Methanococcus aeolicus Nankai-3
          Length = 422

 Score = 40.3 bits (90), Expect = 0.097
 Identities = 25/101 (24%), Positives = 49/101 (48%), Gaps = 4/101 (3%)

Query: 127 FYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIF 186
           + +GS +L ++ +HSL+D +  + +  G+  S +  +   PYGY+    ++SL     IF
Sbjct: 30  YISGSVALIADALHSLSDVLGPIAVYVGLKISQKKPNMKFPYGYSRAETLASLFVSFIIF 89

Query: 187 CVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGAT 227
             G   +    +    +P P+   Y A  ++   ++S G T
Sbjct: 90  LTGVE-TLRQSIDKFFNPSPI-SHYGAVIIV--VLISIGIT 126


>UniRef50_Q8L725 Cluster: Metal tolerance protein C1; n=2;
           Arabidopsis thaliana|Rep: Metal tolerance protein C1 -
           Arabidopsis thaliana (Mouse-ear cress)
          Length = 471

 Score = 40.3 bits (90), Expect = 0.097
 Identities = 45/242 (18%), Positives = 104/242 (42%), Gaps = 18/242 (7%)

Query: 122 KLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLIS 181
           K    +  GS ++ ++  HS++D V   +       +    D +HPYG+     + +L  
Sbjct: 91  KALTGYLCGSTAIIADAAHSVSDVVLSGVALVSYRAANVPKDKEHPYGHGKFETLGALGI 150

Query: 182 GVGIFCVGSGLSFYH----GVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRK 237
              +   GSG++++      +     P+ +H  +     +   +++   T+ +A  +I++
Sbjct: 151 SAMLLATGSGIAWHALDLLSIALSAAPEVIHSGHHHGIDMNHPILA--LTVTIASISIKE 208

Query: 238 GAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLP----DAL 293
           G       LY    R+ +   + +++ +        + +S +A+    G+ L     D L
Sbjct: 209 G-------LYWITKRAGEKQGSGLMMANAWHHRSDAI-SSLVALVGVGGSILGVNFLDPL 260

Query: 294 GSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDVKGIDIGS 353
             ++V T++          ++  LV  +IP +QL+ I   + +   ++  H ++G   GS
Sbjct: 261 AGLVVSTMIVNAGLKTGHQSILELVDAAIPAQQLEPIRQTILQVEGVKGCHRLRGRRAGS 320

Query: 354 NL 355
           +L
Sbjct: 321 SL 322


>UniRef50_Q2PY00 Cluster: Nucleoside transporter; n=1; uncultured
           marine bacterium Ant4D5|Rep: Nucleoside transporter -
           uncultured marine bacterium Ant4D5
          Length = 435

 Score = 39.9 bits (89), Expect = 0.13
 Identities = 22/96 (22%), Positives = 49/96 (51%), Gaps = 4/96 (4%)

Query: 215 FVLGGAVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIV 274
           +V+   + + GA  + A S I  G  E+ + +  Y+ R ++  +  ++    A ++G ++
Sbjct: 147 WVMQRTMKTSGAETLCAASNIFVGMMESPLVVKPYIERMTESELMAIMTAGLATISGSVL 206

Query: 275 AASCMAISQYTGNPLPDALGSILVGTILGGVASFII 310
           AA    +S +     PDA G ++  +I+   A+F++
Sbjct: 207 AAYAGMLSPFE----PDAAGHLIAASIMSAPAAFVM 238


>UniRef50_Q036T5 Cluster: Predicted Co/Zn/Cd cation transporter;
           n=1; Lactobacillus casei ATCC 334|Rep: Predicted
           Co/Zn/Cd cation transporter - Lactobacillus casei
           (strain ATCC 334)
          Length = 349

 Score = 39.9 bits (89), Expect = 0.13
 Identities = 20/70 (28%), Positives = 40/70 (57%), Gaps = 2/70 (2%)

Query: 131 SHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGS 190
           S +L ++ +++L    + LIL +G+  S Q  D +H +G+   + +++L SG+ +  VG 
Sbjct: 48  SRALAADGLNNLTGVASALILLWGLQISQQRPDSEHRFGHWRFQTIATLFSGLIMLVVGL 107

Query: 191 G--LSFYHGV 198
              +  YHG+
Sbjct: 108 DVVIDGYHGL 117


>UniRef50_A6EF02 Cluster: Cation efflux system protein; n=1;
           Pedobacter sp. BAL39|Rep: Cation efflux system protein -
           Pedobacter sp. BAL39
          Length = 292

 Score = 39.9 bits (89), Expect = 0.13
 Identities = 26/99 (26%), Positives = 50/99 (50%), Gaps = 4/99 (4%)

Query: 128 YTG-SHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIF 186
           Y G S++L ++   S AD ++  +L   +  + +  D  HPYG+     V++++  +G+F
Sbjct: 30  YLGHSYALIADATESGADVISSGLLWLALLYAQRPPDKGHPYGHGKAEPVAAVV--IGLF 87

Query: 187 CVG-SGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSE 224
            +G +G   YH +  I  P  L   +  + +L   +V E
Sbjct: 88  LLGAAGWIAYHAIGYINTPHALPGKFTLFVLLAVVLVKE 126


>UniRef50_A6CGW2 Cluster: Putative cation efflux system protein;
           n=1; Planctomyces maris DSM 8797|Rep: Putative cation
           efflux system protein - Planctomyces maris DSM 8797
          Length = 331

 Score = 39.9 bits (89), Expect = 0.13
 Identities = 23/94 (24%), Positives = 41/94 (43%)

Query: 102 TRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQM 161
           TR  +V    I +     + +L   ++ G   L  + + S AD +  L + + I  + Q 
Sbjct: 41  TRLFKVAWLGISVRLFVIVMELVGLWFLGHSVLLVDALASSADVLTSLAILFAIRLAEQP 100

Query: 162 ADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFY 195
            D DHP+G+     ++    G+ I  VG+    Y
Sbjct: 101 PDDDHPFGHGRYEPLAGFQLGILILIVGAATFGY 134


>UniRef50_A4M6M7 Cluster: Cation diffusion facilitator family
           transporter; n=1; Petrotoga mobilis SJ95|Rep: Cation
           diffusion facilitator family transporter - Petrotoga
           mobilis SJ95
          Length = 323

 Score = 39.9 bits (89), Expect = 0.13
 Identities = 28/112 (25%), Positives = 49/112 (43%), Gaps = 7/112 (6%)

Query: 114 INGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNM 173
           ING    FKL   F TGS ++ ++ I +  D +  ++       S + AD  HP+G+   
Sbjct: 30  INGALAFFKLVISFITGSMAILADGIDTTTDIITSILTLIASKISSKPADDSHPFGHERA 89

Query: 174 RYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDF--YWAYFVLGGAVVS 223
             + + +  + I   G     +  + G +     H F  Y  Y VL  +++S
Sbjct: 90  ETIVTKVLSLVIIYAG-----FQVLIGAIQSIITHSFSIYRPYLVLWISLIS 136


>UniRef50_A4IN96 Cluster: Cation efflux family protein; n=3;
           Bacillaceae|Rep: Cation efflux family protein -
           Geobacillus thermodenitrificans (strain NG80-2)
          Length = 296

 Score = 39.9 bits (89), Expect = 0.13
 Identities = 24/95 (25%), Positives = 48/95 (50%)

Query: 95  VEEVGLKTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYG 154
           V+ V  K R+    L +IG+       KL A    GS  + ++  ++L+D +  + +  G
Sbjct: 2   VKNVEWKQRAEAGALLSIGVYLLLAACKLLAGSLAGSDGVKADGWNNLSDVIASVAVYIG 61

Query: 155 IHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVG 189
           +  + +  D +HPYG++    +SSL++   +  +G
Sbjct: 62  MKIAQKPRDRNHPYGHSRAENISSLLAAFLMMSIG 96


>UniRef50_A3DKT1 Cluster: Cation diffusion facilitator family
           transporter; n=1; Staphylothermus marinus F1|Rep: Cation
           diffusion facilitator family transporter -
           Staphylothermus marinus (strain ATCC 43588 / DSM 3639 /
           F1)
          Length = 284

 Score = 39.9 bits (89), Expect = 0.13
 Identities = 29/120 (24%), Positives = 55/120 (45%), Gaps = 8/120 (6%)

Query: 120 LFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSL 179
           L K+    +  S SL  + + S A+ V  + + Y    S+   D DHPYG+  +  +  +
Sbjct: 24  LVKIYGAIFYNSRSLLVDALTSFANIVALIFIVYFYKLSISPPDIDHPYGHHRLG-IGGI 82

Query: 180 ISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGA 239
           I+ +  +   +G+S+   V   +    +   Y+A   + G ++     L+  L AIR G+
Sbjct: 83  IASIAAYSFVAGVSYTELVYSTVYTVQIQSVYYA---IAGFII----YLITILLAIRIGS 135


>UniRef50_Q607F9 Cluster: Cation efflux family protein; n=7;
           Bacteria|Rep: Cation efflux family protein -
           Methylococcus capsulatus
          Length = 376

 Score = 39.5 bits (88), Expect = 0.17
 Identities = 54/235 (22%), Positives = 93/235 (39%), Gaps = 19/235 (8%)

Query: 122 KLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLIS 181
           K  A+  TGS  L S+ + S+ +    ++    +  S Q AD  H +G+    Y +S   
Sbjct: 25  KAAAYRVTGSVGLLSDALESIVNLSAAVVALAMLRLSAQPADARHHFGHGKAEYFASGFE 84

Query: 182 GVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGARE 241
           GV +  V +G   +      L P  L +      +   A V  G    + +S  RK    
Sbjct: 85  GV-LILVAAGAILFAAWDRYLHPHELAELDLGLGLSVAAAVVNGLVGWLLVSVGRKAGS- 142

Query: 242 ANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGTI 301
                   ++  +D      LL D     GV+   +   +   TG    D   + LVG  
Sbjct: 143 --------IVLEADGKH---LLTDVWTSIGVVCGVAAAGL---TGWHDFDPGVAALVGLN 188

Query: 302 LGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAI--HDVKGIDIGSN 354
           +    + +I   +  L+  S+P E+  +I  +LE  F  R +  HD++    G++
Sbjct: 189 IVWTGAGLIRRTIAGLLDASLPLEENLKIRGILE-TFRERGVGFHDLRTRQSGAH 242


>UniRef50_A5WCY6 Cluster: Cation diffusion facilitator family
           transporter; n=2; Psychrobacter|Rep: Cation diffusion
           facilitator family transporter - Psychrobacter sp.
           PRwf-1
          Length = 359

 Score = 39.5 bits (88), Expect = 0.17
 Identities = 43/173 (24%), Positives = 77/173 (44%), Gaps = 11/173 (6%)

Query: 261 VLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGR 320
           VL +   +VA +I A + M +  +  +P+   + ++L+  ++ G   F ++     ++  
Sbjct: 193 VLGDLLGSVAAIIAALAMMWMGWWWADPVASVIVAVLI--LMSG---FRVVKASTHILME 247

Query: 321 SIPHE-QLDEINSVLERDFMIRAIHD--VKGIDIGSNLIRYKAEVDFDGRALTRSYLEKH 377
             P E  LD++   +E +  I A+HD  V  I  G + +     VD D R L  S L  H
Sbjct: 248 GTPEEISLDDVKHTIEHNEHIIAVHDLHVWSITSGLHALSCHVVVDGDMRILEASEL-IH 306

Query: 378 DLNALLEDMKKIDTIDDVETFLLKHGENIVDMLGGEIDRIELKLRKKFPQIRH 430
           +L   LE +    T   VE+  ++H  N +D +   ++  E         I H
Sbjct: 307 ELEHSLERLGISHTTIQVES--IEHPHNRLDAITCALEDTETSRHSGHSHIGH 357


>UniRef50_A1ZDC5 Cluster: Heavy metal efflux pump, CzcD family; n=1;
           Microscilla marina ATCC 23134|Rep: Heavy metal efflux
           pump, CzcD family - Microscilla marina ATCC 23134
          Length = 331

 Score = 39.5 bits (88), Expect = 0.17
 Identities = 26/98 (26%), Positives = 45/98 (45%), Gaps = 1/98 (1%)

Query: 111 AIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGY 170
           A  +N C  + +L     T S ++ S+ IH L DT+      +    S +  D  + YGY
Sbjct: 54  AFFLNFCFTIIELIGGVLTNSMAIMSDAIHDLGDTIAIGSAWFMERYSEKGCDDRYNYGY 113

Query: 171 TNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLH 208
                +S+ I+ V I  VGS   F   +  ++ P+ ++
Sbjct: 114 KRFSPLSAFITSV-ILIVGSVFIFIETIPRLIHPEAVN 150


>UniRef50_A3H9P4 Cluster: Cation diffusion facilitator family
           transporter; n=1; Caldivirga maquilingensis IC-167|Rep:
           Cation diffusion facilitator family transporter -
           Caldivirga maquilingensis IC-167
          Length = 298

 Score = 39.5 bits (88), Expect = 0.17
 Identities = 35/156 (22%), Positives = 67/156 (42%), Gaps = 11/156 (7%)

Query: 134 LFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSS-----LISGVGIFCV 188
           L ++ +H++ D V    L  G+  +++  D DHPYG+   RY+S      +I G  ++ V
Sbjct: 53  LIADGLHTMLDVVILGSLYIGLGPTLKPPDMDHPYGHFKYRYLSMYTVAIIIMGASLWLV 112

Query: 189 GSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGAREANMSLYE 248
              +     + G+++  PL   Y     + G V+S    L + +  I+ G     +    
Sbjct: 113 AEAIISI--IKGVIERLPLDSLY-VIIAVAGLVLSR--LLYLRIGYIKTGDLILKLEFRH 167

Query: 249 YVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQY 284
            +    D  +    L   + +  +I   + MAI+ Y
Sbjct: 168 AIADLLDALLIAATLV-VSLIIPIIQPVAVMAIAAY 202


>UniRef50_Q6D7E5 Cluster: Zinc transporter zitB; n=40;
           Enterobacteriaceae|Rep: Zinc transporter zitB - Erwinia
           carotovora subsp. atroseptica (Pectobacterium
           atrosepticum)
          Length = 320

 Score = 39.5 bits (88), Expect = 0.17
 Identities = 50/235 (21%), Positives = 99/235 (42%), Gaps = 29/235 (12%)

Query: 102 TRSG--RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSV 159
           T SG  + +L A  I     + ++     +GS +L ++  H L D     +    +  + 
Sbjct: 8   TESGNSKRLLAAFIITATFMVAEVIGGLLSGSLALLADAGHMLTDAAALFVALVAVRFAQ 67

Query: 160 QMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGG 219
           +  +  H +GY  +  +++ ++ + +  + +   F+  +    DPQP+         + G
Sbjct: 68  RKPNARHTFGYLRLTTLAAFVNALTLILI-TAFIFWEAIQRFYDPQPVAGVPMLLVAIAG 126

Query: 220 AVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCM 279
            + +     +VA   +  G+ E N+++    +          +L D     G I AA  +
Sbjct: 127 LLAN-----IVAFWLLHHGSEEKNINVRAAALH---------VLGDLLGSVGAIAAAIII 172

Query: 280 AISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVL 334
             + +T  P+ D + SILV        S ++L +  AL+  SI HE L+   S L
Sbjct: 173 LYTNWT--PI-DPILSILV--------SCLVLRSAWALLKESI-HELLEGTPSQL 215


>UniRef50_Q12263 Cluster: Serine/threonine-protein kinase GIN4; n=4;
           Eukaryota|Rep: Serine/threonine-protein kinase GIN4 -
           Saccharomyces cerevisiae (Baker's yeast)
          Length = 1142

 Score = 39.5 bits (88), Expect = 0.17
 Identities = 36/126 (28%), Positives = 59/126 (46%), Gaps = 12/126 (9%)

Query: 312 SNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDVKGIDIGSNLIRYKAEVDFDGRALTR 371
           SN   L+     +E+ ++I    E++ + R + + K  +    L R + + +   RA  R
Sbjct: 541 SNFATLIDEIFEYEKYEQIRK--EKEELERKVREAKARE---ELERRRRKQEEKERA--R 593

Query: 372 SYLEKHDLNALLEDMKKIDTID--DVETFLLKHGENIVDMLGGEIDRIELKLRKKFPQIR 429
             LEK DL    E++KK   ID  D+E  L KH E   + L G I  I   +  +   I 
Sbjct: 594 KLLEKEDLKRKQEELKKQIEIDISDLEQELSKHKE---EKLDGNIRSISAPMENEEKNIN 650

Query: 430 HCDLEI 435
           H +++I
Sbjct: 651 HLEVDI 656


>UniRef50_Q2NTU9 Cluster: Putative transport protein; n=1; Sodalis
           glossinidius str. 'morsitans'|Rep: Putative transport
           protein - Sodalis glossinidius (strain morsitans)
          Length = 342

 Score = 39.1 bits (87), Expect = 0.22
 Identities = 49/273 (17%), Positives = 106/273 (38%), Gaps = 17/273 (6%)

Query: 95  VEEVGLKTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYG 154
           + ++  K+ +    L ++G+       K+ AW  TGS +L +     L D +  ++   G
Sbjct: 2   IAKLSKKSLTRLASLVSLGVALTLVYIKIWAWIETGSIALLTSAADGLVDVLASMVTLVG 61

Query: 155 IHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAY 214
            + + + AD  H +G+     +++ +    +      L     ++  + PQPL       
Sbjct: 62  GYYAQRPADRGHRFGHGKAEAIAAFVQARRLAAAEVALG-VESISRPITPQPL------- 113

Query: 215 FVLGGAVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIV 274
                AV   G  ++VA +            + +Y   ++  +     + D A    V+ 
Sbjct: 114 -----AVQRLGIIVIVASTLCASLLVTMQTRVVKYTQSTAIAADRAHYITDIAVNIAVLC 168

Query: 275 AASCMAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVL 334
           A   + +    G    DA G++ +   +   A  II S +  L+ R +       I +  
Sbjct: 169 A---LVLENQFGWVRADASGALAISCYMVWNARGIIQSAMLQLLDRELDSADRRRITAAA 225

Query: 335 ERDFMIRAIHDVKGIDIGSNLIRYKAEVDFDGR 367
                +  +HD++  + G + +  +  V+ DG+
Sbjct: 226 LNCPGVEGVHDLRTRN-GGDRVFVELHVEVDGQ 257


>UniRef50_O67851 Cluster: Putative uncharacterized protein; n=1;
           Aquifex aeolicus|Rep: Putative uncharacterized protein -
           Aquifex aeolicus
          Length = 385

 Score = 39.1 bits (87), Expect = 0.22
 Identities = 23/72 (31%), Positives = 33/72 (45%), Gaps = 1/72 (1%)

Query: 109 LTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPY 168
           L + G N    L KL     TGS SL  + IHSL+D    LI    I K  ++     PY
Sbjct: 8   LVSFGFNIFQSLIKLVGGLLTGSLSLIGDAIHSLSDATASLIAFLSI-KFSEIKSERFPY 66

Query: 169 GYTNMRYVSSLI 180
           G   +  + +++
Sbjct: 67  GLYKLENIGAIV 78


>UniRef50_A0VV15 Cluster: Cation diffusion facilitator family
           transporter; n=6; Alphaproteobacteria|Rep: Cation
           diffusion facilitator family transporter -
           Dinoroseobacter shibae DFL 12
          Length = 328

 Score = 39.1 bits (87), Expect = 0.22
 Identities = 37/168 (22%), Positives = 70/168 (41%), Gaps = 2/168 (1%)

Query: 104 SGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMAD 163
           SG+ ++ +  + G  F+ +L    +TGS ++ S+  H+L+     L+       + + AD
Sbjct: 13  SGKALVISAWLTGVYFVIELAVGLWTGSIAVLSDAFHTLSAVGGVLVAITAQRIARRPAD 72

Query: 164 PDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVS 223
               +G+     + +L++G G     + L  + G   + DP  L      +   GG V  
Sbjct: 73  STRSFGWYRAEIIGALVNG-GFLLGMALLVIWMGAMRLGDPIHLATGPMLWVAFGGLVTE 131

Query: 224 -EGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVA 270
                LM   S     AR A   + +  + S    V  +++E T  +A
Sbjct: 132 VVSLALMWQSSKDDLNARGALWHIIQTFVGSLLIIVTALVIEFTGFLA 179


>UniRef50_UPI0000499CA1 Cluster: cation diffusion facilitator family
           protein; n=1; Entamoeba histolytica HM-1:IMSS|Rep:
           cation diffusion facilitator family protein - Entamoeba
           histolytica HM-1:IMSS
          Length = 437

 Score = 38.7 bits (86), Expect = 0.30
 Identities = 32/134 (23%), Positives = 56/134 (41%), Gaps = 3/134 (2%)

Query: 114 INGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNM 173
           +N C FLF+L    Y  S  L  +  + L+D ++Q+I         Q       YG+T  
Sbjct: 70  MNFCYFLFELIIGLYLNSLILTVDSFNMLSDILSQIIGLTATIIMKQNFSSKFTYGFTRA 129

Query: 174 RYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSE--GATLMVA 231
               + I+ V    +G  +S    +    + + + D  +   V GG +V    G  ++  
Sbjct: 130 EVTGAFINSVFQISIGLFMSI-QSIESFFELEEVKDPLFLLAVSGGGLVVNIIGMIILHE 188

Query: 232 LSAIRKGAREANMS 245
            S I+K  ++ N S
Sbjct: 189 YSCIKKVNKKINSS 202


>UniRef50_Q3AYC0 Cluster: Cation efflux protein; n=13;
           Cyanobacteria|Rep: Cation efflux protein - Synechococcus
           sp. (strain CC9902)
          Length = 308

 Score = 38.7 bits (86), Expect = 0.30
 Identities = 25/82 (30%), Positives = 40/82 (48%), Gaps = 1/82 (1%)

Query: 106 RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD 165
           RV+  A+ +N    L KL     +GS ++ ++ +HS  D ++ L        S    D D
Sbjct: 18  RVLAVALVMNIAMSLLKLSVGVLSGSLAVIADAMHSATDALSSLTGLITNSLSDPRPDRD 77

Query: 166 HPYGYTNMRYVSSL-ISGVGIF 186
           HPYG+     V +L I+G  +F
Sbjct: 78  HPYGHHKYEAVGALGIAGFILF 99


>UniRef50_Q2NBG7 Cluster: Cation efflux system protein; n=3;
           Proteobacteria|Rep: Cation efflux system protein -
           Erythrobacter litoralis (strain HTCC2594)
          Length = 317

 Score = 38.7 bits (86), Expect = 0.30
 Identities = 48/228 (21%), Positives = 98/228 (42%), Gaps = 13/228 (5%)

Query: 99  GLKTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKS 158
           G +  S R ++ A+ IN    L ++     +GS +L ++ +H+ +D  +  +  +     
Sbjct: 13  GEENLSDRQLILAVAINVLLTLAQIVGGILSGSLALIADALHNFSDAASLGLAWFARRIG 72

Query: 159 VQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLG 218
            + AD    +GY     V++LI+   +  +G  L     +     PQP+ + +   +V G
Sbjct: 73  RRPADKLMTFGYAQGEVVAALINLTTLLIIGFYL-IVEAINRFAAPQPV-EGWTVIWVAG 130

Query: 219 GAVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSD--PSVNVV-----LLEDTAAVAG 271
            A+V +  T  +    + +GA ++      ++   SD   S+ V+     ++     VA 
Sbjct: 131 IALVIDLVTAFI----VYRGAHDSINMKAAFLHNVSDALASIGVIVAGVLIILYDLVVAD 186

Query: 272 VIVAASCMAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVG 319
           +I+     A   + G  L      +L+G +   V    ++ N+ AL G
Sbjct: 187 LIITLIIAAYVIWQGATLLPRTVRLLMGAVPDEVEFDQMVENLRALGG 234


>UniRef50_A5TUV7 Cluster: Possible CDF family cation diffusion
           facilitator, cadmium (Cd2+), zinc (Zn2+), cobalt (Co2+)
           efflux permease; n=3; Fusobacterium nucleatum|Rep:
           Possible CDF family cation diffusion facilitator,
           cadmium (Cd2+), zinc (Zn2+), cobalt (Co2+) efflux
           permease - Fusobacterium nucleatum subsp. polymorphum
           ATCC 10953
          Length = 372

 Score = 38.7 bits (86), Expect = 0.30
 Identities = 44/215 (20%), Positives = 91/215 (42%), Gaps = 17/215 (7%)

Query: 120 LFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSL 179
           +FK      + S ++  + +++L+D ++ ++       +    D  HP G+  + Y+S++
Sbjct: 29  VFKAIIGLISNSIAILLDAVNNLSDALSSIVTIIATKLADSEPDKKHPLGHGRIEYLSAM 88

Query: 180 ISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGA 239
           I    IF  G   S    +  I +P  +      + +L   +VS    L++       G 
Sbjct: 89  IVAGIIFYAGI-TSLIESIKKIFNPLEVEYSKVTFIIL---IVSIVLKLLLGRYVKNIGE 144

Query: 240 REANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVG 299
           +  + SL   V   SD + + + L  +  V+ ++   + + I  Y G      L SI + 
Sbjct: 145 KFNSPSL---VASGSDATFDAI-LSSSVLVSAILYIFTDINIEAYVG-----VLISIFI- 194

Query: 300 TILGGVASFIILSNVGALVGRSIPHEQLDEINSVL 334
            I  G+   I +  V  ++G  +  E ++EI   +
Sbjct: 195 -IKSGIE--IFMEAVNEILGERVDKETINEIKKTI 226


>UniRef50_A1W8N6 Cluster: Putative uncharacterized protein; n=3;
           Comamonadaceae|Rep: Putative uncharacterized protein -
           Acidovorax sp. (strain JS42)
          Length = 125

 Score = 38.7 bits (86), Expect = 0.30
 Identities = 22/60 (36%), Positives = 30/60 (50%), Gaps = 1/60 (1%)

Query: 269 VAGVIVAASCMAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLD 328
           VAGV+  AS  A       P+  A+GS+L G ++GGV    +   VG  +G  I    LD
Sbjct: 54  VAGVVQGASTGASVGMVAGPVGSAIGSLL-GALIGGVVGGTVGQEVGGRIGEQIDQTYLD 112


>UniRef50_A1D9L0 Cluster: Di-, tri-valent inorganic cation
           transporter, putative; n=2; Trichocomaceae|Rep: Di-,
           tri-valent inorganic cation transporter, putative -
           Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / NRRL
           181)(Aspergillus fischerianus (strain ATCC 1020 / DSM
           3700 / NRRL 181))
          Length = 345

 Score = 38.7 bits (86), Expect = 0.30
 Identities = 23/90 (25%), Positives = 46/90 (51%), Gaps = 4/90 (4%)

Query: 102 TRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQM 161
           +RS R+++  IGI+ C FL ++    YT S +L ++  H L D +  ++    + K  ++
Sbjct: 6   SRSQRLIMV-IGISSCFFLTEISIGLYTHSLALVADAFHYLTDLIGFVVALLAL-KLSEI 63

Query: 162 ADPDH--PYGYTNMRYVSSLISGVGIFCVG 189
            DP     +G+     + +  +G  +F +G
Sbjct: 64  DDPPKILAFGWQRAPLLGAFFNGALLFALG 93


>UniRef50_Q8TV30 Cluster: Predicted Co/Zn/Cd cation transporter;
           n=1; Methanopyrus kandleri|Rep: Predicted Co/Zn/Cd
           cation transporter - Methanopyrus kandleri
          Length = 293

 Score = 38.7 bits (86), Expect = 0.30
 Identities = 31/117 (26%), Positives = 51/117 (43%), Gaps = 5/117 (4%)

Query: 112 IGINGCNFL--FKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYG 169
           IGI G   L   K+       S +L S+ +HSL DTV+ +++  G   + +  D  H YG
Sbjct: 17  IGIYGNILLSVLKIAIGHIASSWALVSDGVHSLGDTVSSVMVLLGAKVARKPPDARHMYG 76

Query: 170 YTNMRYVSSLISGVGIFCVGSG-LSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEG 225
           +     ++ L  GV +    +G L  +  +  + +P+P          LG     EG
Sbjct: 77  HYKAEALAGL--GVSMMVTFTGLLLLWESLMRLRNPEPPTSTLPLVVALGTVAAKEG 131


>UniRef50_Q7MT89 Cluster: Cation efflux family protein; n=3;
           Bacteroidales|Rep: Cation efflux family protein -
           Porphyromonas gingivalis (Bacteroides gingivalis)
          Length = 302

 Score = 38.3 bits (85), Expect = 0.39
 Identities = 58/275 (21%), Positives = 120/275 (43%), Gaps = 29/275 (10%)

Query: 103 RSGRVV-LTAIGINGCNFLFKLCAWF--YTG-SHSLFSECIHSLADTVNQLILAYGIHKS 158
           RS R+  +T +G  G N L  +  +F  + G S ++ ++ +HSL+D +   ++   I  S
Sbjct: 10  RSRRIKRITIVGCLG-NLLLTIGKFFSGFVGHSGAMIADAVHSLSDLLTDFVVFIFISIS 68

Query: 159 VQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLG 218
            + +D +H YG+     +++ I  V +  +G+ L    G+T +          + Y   G
Sbjct: 69  GKPSDKNHDYGHGKFETLATAIIAVTLIIIGAMLC-SDGLTKV----------YRYLRFG 117

Query: 219 GAVVSEG--ATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVL-----LEDTAAVAG 271
             +   G  A LM  +S +   A+E    +   V +  + S +V+        D      
Sbjct: 118 DELARPGLIALLMAFVSIV---AKEWLFRITRCVGKEEN-SRSVIANAWHHRSDAYTSVA 173

Query: 272 VIVAASCMAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEIN 331
             +   C A     G  + + L + +V   +  V   + +     L+ +S+P +  +EI 
Sbjct: 174 TFIGIGC-AFLLGRGWMILEPLSAAVVSVFIIKVGFQMAVPAFRDLLEQSLPDDIEEEIE 232

Query: 332 SVLERDFMIRAIHDVKGIDIGSNLIRYKAEVDFDG 366
            ++  + M++ +  ++  +IG N    +A++  DG
Sbjct: 233 KIICSESMVKGVRRIRTRNIG-NYYAVEADILMDG 266


>UniRef50_Q3ZWB7 Cluster: Cation efflux family protein; n=2;
           Dehalococcoides|Rep: Cation efflux family protein -
           Dehalococcoides sp. (strain CBDB1)
          Length = 316

 Score = 38.3 bits (85), Expect = 0.39
 Identities = 42/196 (21%), Positives = 88/196 (44%), Gaps = 21/196 (10%)

Query: 115 NGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMR 174
           +G   L +      + S +L S+  H L D +   +  + + ++ + ++    +GY  + 
Sbjct: 28  SGIILLAEFVGGLASNSLALLSDAGHVLTDVLALSLSYFALMQAKRPSNFKMTFGYHRIG 87

Query: 175 YVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSA 234
            + ++++ + +  +   + FY        P  ++    A+ VL  A++     L VAL  
Sbjct: 88  VLVAILNSISLIGIAVFI-FYESFQRFQSPPEIN----AWLVLPVALLGLATNLAVAL-- 140

Query: 235 IRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALG 294
           I    ++ N+++      ++          DT A  GVI++A    +  Y+GN L D + 
Sbjct: 141 ILHSEQKENLNIKSAFWHAAG---------DTLASVGVIISA---VVVIYSGNYLADIIV 188

Query: 295 SILVGTI--LGGVASF 308
           S+++G I  LGG+  F
Sbjct: 189 SVIIGLIISLGGINIF 204


>UniRef50_Q1IPF4 Cluster: Cation diffusion facilitator family
           transporter; n=1; Acidobacteria bacterium Ellin345|Rep:
           Cation diffusion facilitator family transporter -
           Acidobacteria bacterium (strain Ellin345)
          Length = 483

 Score = 38.3 bits (85), Expect = 0.39
 Identities = 25/73 (34%), Positives = 33/73 (45%), Gaps = 4/73 (5%)

Query: 108 VLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHP 167
           V  AI I G     K+    YTGS  + SE  HS  D +   I    I  S + AD DH 
Sbjct: 31  VFAAIFITG----LKVVVGVYTGSLGILSEAAHSGLDLIAAFITFMSIRVSDKPADADHQ 86

Query: 168 YGYTNMRYVSSLI 180
           +G+  +   S+ I
Sbjct: 87  FGHGKVENFSAFI 99


>UniRef50_A3UGA9 Cluster: Cation efflux protein; n=3;
           Proteobacteria|Rep: Cation efflux protein - Oceanicaulis
           alexandrii HTCC2633
          Length = 321

 Score = 38.3 bits (85), Expect = 0.39
 Identities = 58/242 (23%), Positives = 108/242 (44%), Gaps = 26/242 (10%)

Query: 109 LTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHK-SVQMADPDHP 167
           L A  + G   L ++     TGS +L ++  H L D    LILA+G  + S + A     
Sbjct: 44  LIAAALTGGFMLAEVIGGLLTGSLALLADAAHMLTDFA-ALILAWGAFRLSRRPATDKRS 102

Query: 168 YGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGAT 227
           YGY  ++ +++  +GV +  +   ++    V  + DP  +         + G +V+    
Sbjct: 103 YGYDRLQILAAFANGVTLSILVVWIA-CEAVMRLFDPNEIEATGMMVIAVLGLIVN---- 157

Query: 228 LMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGN 287
             +A   +  GA   N+++     R +   V   LL   AA    I+AA  +  + +T  
Sbjct: 158 --IAAFGVLHGADTDNLNI-----RGALAHVMGDLLGSVAA----IIAAGVIWWTGWT-- 204

Query: 288 PLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDVK 347
           P+   L  ++ G I  G++++ ++ + G ++  + P + +D   SVL  D +   I DV 
Sbjct: 205 PIDPLLSLLIAGLI--GISAWRLVRDAGRVLLEAAP-DHIDP--SVLRAD-LTAEIEDVL 258

Query: 348 GI 349
            I
Sbjct: 259 DI 260


>UniRef50_A4HFQ2 Cluster: Cation transporter, putative; n=3;
           Leishmania|Rep: Cation transporter, putative -
           Leishmania braziliensis
          Length = 663

 Score = 38.3 bits (85), Expect = 0.39
 Identities = 47/224 (20%), Positives = 87/224 (38%), Gaps = 17/224 (7%)

Query: 131 SHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD-HPYGYTNMRYVSSLISGVGIFCVG 189
           S  L S+  H + D  + +I  Y  H +  + D   HP+GY         ++G+ +  + 
Sbjct: 393 SLGLVSDSFHMMLDGTSIMIGLYAAHAASWLPDEKTHPFGYARYEVFGGFVNGILLLFIA 452

Query: 190 SGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMV--ALSAIRKGAREANMSLY 247
             +     V   LDP  +   Y     + G  V+    L    A         E      
Sbjct: 453 LYV-MVESVQRFLDPPEIEGPYLLLVSVTGLAVNVVGVLFFHDAHGHSHSALHEDGGGHV 511

Query: 248 EYVMRSSDPSVNVVLLEDTAAVAGVIVAASCM-AISQYTGNPLPDALGSILVGTILGGVA 306
           ++ MR     V + +L D      VI++++ M     +  +P+  A+ +ILV      ++
Sbjct: 512 DHNMR----GVYLHILADLLGSVSVIISSTLMYMFGLWIADPICSAISAILV-----LLS 562

Query: 307 SFIILSNVGALVGRSIP---HEQLDEINSVLERDFMIRAIHDVK 347
           +F +L   G ++  S P       DE+  VL    +++ +   K
Sbjct: 563 AFPLLEETGRVLLLSAPSYERNYSDELRKVLLETALLQDVESPK 606


>UniRef50_Q6CT16 Cluster: Kluyveromyces lactis strain NRRL Y-1140
           chromosome C of strain NRRL Y- 1140 of Kluyveromyces
           lactis; n=3; Saccharomycetales|Rep: Kluyveromyces lactis
           strain NRRL Y-1140 chromosome C of strain NRRL Y- 1140
           of Kluyveromyces lactis - Kluyveromyces lactis (Yeast)
           (Candida sphaerica)
          Length = 513

 Score = 38.3 bits (85), Expect = 0.39
 Identities = 19/86 (22%), Positives = 42/86 (48%), Gaps = 2/86 (2%)

Query: 131 SHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVG- 189
           S +L ++ +H+++D V+  +  + +  + +    D+PYGY  +  + SL     +   G 
Sbjct: 168 SQALIADSVHAISDLVSDFLTLFSVGLATRKPTNDYPYGYGKVETIGSLAVSSILTTAGL 227

Query: 190 -SGLSFYHGVTGILDPQPLHDFYWAY 214
             G S    + G + P  + +F+ A+
Sbjct: 228 SIGWSSLCAIAGPIVPHAILEFFAAH 253


>UniRef50_Q0CAH3 Cluster: Predicted protein; n=1; Aspergillus
           terreus NIH2624|Rep: Predicted protein - Aspergillus
           terreus (strain NIH 2624)
          Length = 365

 Score = 38.3 bits (85), Expect = 0.39
 Identities = 23/85 (27%), Positives = 43/85 (50%), Gaps = 3/85 (3%)

Query: 112 IGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDH-PYGY 170
           IGI+   F+ ++   FYTGS +L ++  H L+D V  ++         + + P    +G+
Sbjct: 15  IGISTSFFIAEIAVGFYTGSLALVADAFHYLSDIVGFVVALVAAIVEQKSSPPQALTFGW 74

Query: 171 TNMRYVSSLISGVGIFCVGSGLSFY 195
              + V +  +GV +F  G G+S +
Sbjct: 75  QRSQLVGAFFNGVLLF--GLGISVF 97


>UniRef50_Q8TP38 Cluster: Cation efflux system protein; n=3;
           Methanosarcinaceae|Rep: Cation efflux system protein -
           Methanosarcina acetivorans
          Length = 411

 Score = 38.3 bits (85), Expect = 0.39
 Identities = 20/63 (31%), Positives = 32/63 (50%)

Query: 127 FYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIF 186
           FY+GS SL ++ IH+  D    L +  G+  S++ ++   PYGY     + SL   + I 
Sbjct: 33  FYSGSASLIADAIHTSLDIFTSLAVWIGLKLSMRGSEEKFPYGYYKADNLVSLFVSIIIL 92

Query: 187 CVG 189
             G
Sbjct: 93  FSG 95


>UniRef50_A0RND9 Cluster: Ferrous-iron efflux pump FieF; n=1;
           Campylobacter fetus subsp. fetus 82-40|Rep: Ferrous-iron
           efflux pump FieF - Campylobacter fetus subsp. fetus
           (strain 82-40)
          Length = 291

 Score = 37.9 bits (84), Expect = 0.52
 Identities = 51/234 (21%), Positives = 95/234 (40%), Gaps = 28/234 (11%)

Query: 120 LFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSL 179
           + K      +GS ++ S  I SL D +   +  + + KS    +    +GY  +  + +L
Sbjct: 18  IIKFAIGLASGSMAVLSSAIDSLLDCLVSALNYFALRKSNSDPNSKFNFGYGKIEALVAL 77

Query: 180 ISGVGIFCVGSGLSF-YHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKG 238
             G   F +G G+   Y  VT I++P+                V  G  +M+ +S I  G
Sbjct: 78  FEGA--FIIGIGIFICYSSVTKIINPEK------------SIEVGAGMIVMI-ISIILTG 122

Query: 239 AREANMSLYEYVMRSSDPSVNVVLLED-----TAAVAGVIVAASCMAISQYTGNPLPDAL 293
           A      L  Y+ R    + N+++  D     T  V    + A+  AI   +G  + DAL
Sbjct: 123 A------LVFYLQREYKKTGNLIIKADALHYQTDLVTNAAILAALFAI-WLSGYDIIDAL 175

Query: 294 GSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDVK 347
             I +   +   A  ++   V  L+  ++P   +  I  ++     +++ H +K
Sbjct: 176 FGIGISVYIVFSAFKLLKEGVYILLDGALPESMVSGIIDIINLKHEVKSYHYLK 229


>UniRef50_A0IKN6 Cluster: Cation diffusion facilitator family
           transporter; n=1; Serratia proteamaculans 568|Rep:
           Cation diffusion facilitator family transporter -
           Serratia proteamaculans 568
          Length = 460

 Score = 37.9 bits (84), Expect = 0.52
 Identities = 20/58 (34%), Positives = 30/58 (51%)

Query: 122 KLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSL 179
           K  A  +TGS  L SE IHS  D +   I    +  S + AD DH +G+  +  +++L
Sbjct: 23  KFIAGIFTGSIGLISEGIHSFTDFIATSITWLAVRISDKPADDDHHFGHGKVENLAAL 80


>UniRef50_Q7NIC0 Cluster: Gll2263 protein; n=2; Cyanobacteria|Rep:
           Gll2263 protein - Gloeobacter violaceus
          Length = 247

 Score = 37.5 bits (83), Expect = 0.69
 Identities = 23/73 (31%), Positives = 36/73 (49%), Gaps = 1/73 (1%)

Query: 269 VAGVIVAASCMAISQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLD 328
           + G++V    +AI          ALG+ L  T+ GG         VGALVG  IP E+ +
Sbjct: 78  LTGLLVGIGALAIPGIGPVITAGALGTALATTLAGGAIGAAAGGLVGALVGLGIPKERAE 137

Query: 329 EINSVLER-DFMI 340
             N+ + R D+++
Sbjct: 138 VYNAAVTRGDYLV 150


>UniRef50_Q749X9 Cluster: Cation efflux family protein; n=8;
           Deltaproteobacteria|Rep: Cation efflux family protein -
           Geobacter sulfurreducens
          Length = 296

 Score = 37.5 bits (83), Expect = 0.69
 Identities = 23/89 (25%), Positives = 41/89 (46%), Gaps = 5/89 (5%)

Query: 103 RSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMA 162
           R+ +V+     +N    + KL A  + GS ++F++ + S  D V  L     +    +  
Sbjct: 9   RAEKVIHLGFWVNAVLMVMKLAAGHFGGSEAVFADGVESGCDFVALLFTMVALRVGRKPF 68

Query: 163 DPDHPYGYTNMRYVSS-----LISGVGIF 186
           D  HPYG+     V++     +I G G+F
Sbjct: 69  DARHPYGHGKAENVAAFVIALVIGGAGMF 97


>UniRef50_Q6LGB2 Cluster: Hypothetical cation-efflux family protein;
           n=4; Vibrionaceae|Rep: Hypothetical cation-efflux family
           protein - Photobacterium profundum (Photobacterium sp.
           (strain SS9))
          Length = 275

 Score = 37.5 bits (83), Expect = 0.69
 Identities = 16/61 (26%), Positives = 31/61 (50%)

Query: 134 LFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLS 193
           + ++ +HS +D V    +  G       AD +HPYG+     ++++  GV +  VG G+ 
Sbjct: 1   MIADGVHSFSDLVTDTAILIGSRYWTAPADKEHPYGHGRFETLTNIFIGVILAIVGIGIG 60

Query: 194 F 194
           +
Sbjct: 61  W 61


>UniRef50_Q2S288 Cluster: Cation efflux family protein; n=1;
           Salinibacter ruber DSM 13855|Rep: Cation efflux family
           protein - Salinibacter ruber (strain DSM 13855)
          Length = 324

 Score = 37.5 bits (83), Expect = 0.69
 Identities = 50/229 (21%), Positives = 91/229 (39%), Gaps = 20/229 (8%)

Query: 122 KLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLIS 181
           KL A   TGS ++ S+   S+          + +  +    D +HPYG+  + Y +S + 
Sbjct: 37  KLTAASLTGSTAILSDAAESVIHLFATGFAGFSLWYASTPPDVEHPYGHGKVAYFASAVE 96

Query: 182 GVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGARE 241
           G  I     G+  +  V  ++    L       +++GG          +    +R G R 
Sbjct: 97  GTLILAAAVGIG-WMAVQDLVTGADLRQLDVGLYLIGGLT---AVNFALGTYLVRVGRRT 152

Query: 242 ANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGTI 301
            ++     V+ S+   V    L D     GVIV    + I   TG    D    +LV   
Sbjct: 153 NSL-----VLESNGEHV----LTDMWTSLGVIVGIGLVWI---TGIRWLDPAVGLLVAAN 200

Query: 302 LGGVASFIILSNVGALVGRS---IPHEQLDEINSVLERDFMIRAIHDVK 347
           +   A+ ++  +V  L+  +        LDE+ + +E + +I + H V+
Sbjct: 201 IVWTATGLLRRSVYGLMDEADWEASSALLDELGTAVE-EGLIASFHQVR 248


>UniRef50_Q2LWF9 Cluster: Co/Zn/Cd cation transporter; n=1;
           Syntrophus aciditrophicus SB|Rep: Co/Zn/Cd cation
           transporter - Syntrophus aciditrophicus (strain SB)
          Length = 421

 Score = 37.5 bits (83), Expect = 0.69
 Identities = 64/251 (25%), Positives = 105/251 (41%), Gaps = 20/251 (7%)

Query: 105 GRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADP 164
           G+V L A  +N      K    F++ S ++ +  I S  D+   L+L  G+  S +   P
Sbjct: 28  GKVALYAFLLNLGLAAMKGVLAFWSDSLAVTAGAIDSATDSAASLVLYGGLKLSTRKT-P 86

Query: 165 DHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSE 224
             P G   +  V S+   + IF  G  ++       +  P+   D      VL   +VS 
Sbjct: 87  SFPEGLYKIENVLSVFVALSIFFAGLEIALKLFKQSVSSPRISLDIV----VL--LLVSV 140

Query: 225 GATLMVALSAIRKGAREANMSLY-EYVMRSSDP-SVNVVLLEDTAAVAGVIVAASCMAIS 282
            AT +    AI  G +  + +L  E   R  D  S +VVL+       G  V+   ++I 
Sbjct: 141 AATFLFGRYAILTGRKTESPTLIAEGRHRQVDVLSSSVVLISVLPEYFGYHVSLFGLSI- 199

Query: 283 QYTGNPLPDALGSILVGTILGGVASFIILSN-VGALVGRSIPHEQLDEINSVLERDFMIR 341
                   D++ +  V  I    A + +LSN +  L+  S+  E LDE  S+L+   M+ 
Sbjct: 200 --------DSIAACAV-LIFIAFAGWELLSNGMRVLLDASLDFETLDEARSILKNHPMVV 250

Query: 342 AIHDVKGIDIG 352
            I  + G + G
Sbjct: 251 NIRSLSGRNAG 261


>UniRef50_A5G751 Cluster: Cation diffusion facilitator family
           transporter; n=1; Geobacter uraniumreducens Rf4|Rep:
           Cation diffusion facilitator family transporter -
           Geobacter uraniumreducens Rf4
          Length = 293

 Score = 37.5 bits (83), Expect = 0.69
 Identities = 29/117 (24%), Positives = 52/117 (44%), Gaps = 1/117 (0%)

Query: 114 INGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNM 173
           +N C  L +L    +T S ++ S  +H L D ++  +  Y    + + +D  + YGY   
Sbjct: 20  LNLCFTLLELFGGLWTNSIAIISNAVHDLGDCLSLGLAWYLAGYAEKESDRRYSYGYRRF 79

Query: 174 RYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMV 230
             + +L + + +  VGS L     V  +L P+  +    A   + G  V+  A L V
Sbjct: 80  SLLGALATAL-VLMVGSLLVLSEAVPRLLRPEHPNAGGMALLAVVGIAVNGLALLRV 135


>UniRef50_A3TRN3 Cluster: Tyrosine protein kinase:Serine/threonine
           protein kinase; n=1; Janibacter sp. HTCC2649|Rep:
           Tyrosine protein kinase:Serine/threonine protein kinase
           - Janibacter sp. HTCC2649
          Length = 583

 Score = 37.5 bits (83), Expect = 0.69
 Identities = 18/41 (43%), Positives = 26/41 (63%)

Query: 268 AVAGVIVAASCMAISQYTGNPLPDALGSILVGTILGGVASF 308
           AV+GV  AA  +   Q TG+P PDAL  + VG +L G+ ++
Sbjct: 477 AVSGVFCAALAVVAIQGTGSPEPDALAPLAVGGLLAGLMAW 517


>UniRef50_A0LKX9 Cluster: Cation diffusion facilitator family
           transporter; n=1; Syntrophobacter fumaroxidans MPOB|Rep:
           Cation diffusion facilitator family transporter -
           Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
          Length = 307

 Score = 37.5 bits (83), Expect = 0.69
 Identities = 20/75 (26%), Positives = 35/75 (46%)

Query: 120 LFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSL 179
           + KL     T S  + +E +HS  D +  +I  + +  S + AD  H YG+  +  VS +
Sbjct: 22  VLKLVVGIMTQSVGVIAEAVHSGLDLLAAVIAWFSVRASGKPADDRHRYGHGQIESVSGV 81

Query: 180 ISGVGIFCVGSGLSF 194
           +  + IF     + F
Sbjct: 82  VEALLIFAAAGCIIF 96


>UniRef50_Q4WLB1 Cluster: CDF zinc transporter (Msc2), putaitve;
           n=7; Eurotiomycetidae|Rep: CDF zinc transporter (Msc2),
           putaitve - Aspergillus fumigatus (Sartorya fumigata)
          Length = 877

 Score = 37.5 bits (83), Expect = 0.69
 Identities = 48/206 (23%), Positives = 85/206 (41%), Gaps = 16/206 (7%)

Query: 100 LKTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSV 159
           LK R  R +   + +N    L +L   F TGS  L S+ IH   D    L L  G+  +V
Sbjct: 510 LKERDSRRIFYFMTLNFTFMLVQLSYGFITGSLGLLSDSIHMFFDC---LALVVGLCAAV 566

Query: 160 QMADPD---HPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFV 216
               P     PYGY  +  +S   +G+ +  +   +  Y  V  +     +H       V
Sbjct: 567 MSKWPSSARFPYGYGKVDTLSGFANGIFLMIISIEI-IYEAVERLSSGSQMHRLGELLAV 625

Query: 217 -LGGAVVSEGATLMVALSAIRKG-AREANMSLYEYVMRSSD-PSVNVVLLEDTAAVAGVI 273
            + G VV+     +V + A   G A   +   + +   + +   + + +L DT     V+
Sbjct: 626 SVAGLVVN-----LVGIMAFDHGHAHHGHDHGHSHSHGNENMHGIFLHILADTLGSVAVV 680

Query: 274 VAASCMAISQYTG-NPLPDALGSILV 298
           ++   +  S + G +P+   L +IL+
Sbjct: 681 ISTILVHFSGWAGYDPIASCLIAILI 706


>UniRef50_Q2FN36 Cluster: Cation diffusion facilitator family
           transporter; n=1; Methanospirillum hungatei JF-1|Rep:
           Cation diffusion facilitator family transporter -
           Methanospirillum hungatei (strain JF-1 / DSM 864)
          Length = 344

 Score = 37.5 bits (83), Expect = 0.69
 Identities = 58/290 (20%), Positives = 127/290 (43%), Gaps = 20/290 (6%)

Query: 86  MSHTRSKDNVE--EVGLKTRSGRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLA 143
           M H +S++ ++  E+ ++    RV+  ++ I+   ++  L     +GS +L +E I    
Sbjct: 31  MVHVQSEEEIKSSEIRMQRLKERVIFKSLIIDTIFWIPSLILAGMSGSVTLSTEAIKKGN 90

Query: 144 DTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILD 203
           + ++       + K  Q     + YG      ++ +++G+ +  +   L F   V  +L+
Sbjct: 91  EILSTFFAWLALKKMSQGGAHAYDYGMGKFENMTGIVTGI-VMILSLVLVFGLTVLKLLN 149

Query: 204 PQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLL 263
           P  LH+      ++   V+  G  + V+    R+    A M  Y  V+ +       + L
Sbjct: 150 PHMLHE---EVTIVAMIVMFTG--ICVSTILWREKVHIAKME-YSPVIEAQ------ITL 197

Query: 264 EDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGTILG--GVASF-IILSNVGALVGR 320
             T A+   +V A+ + +     NP  D +  +    ++G   ++ +  I S++  L+ +
Sbjct: 198 FKTKAITEFVVLAALLLVLFIEDNPWEDYIDPVASFIVIGLFLLSGYRTISSSLPDLLDK 257

Query: 321 SIPHE-QLDEINSVLERDFMIRAIHDVKGIDIGSNLIRYKAEVDFDGRAL 369
           +I  E QL  + S+ +      A H V+    G+++   +  ++FDG  L
Sbjct: 258 TIEEELQLVVVRSLADFFDEYEAFHGVRSRKCGNDIF-IELFLEFDGNRL 306


>UniRef50_O27915 Cluster: Cation efflux system protein; n=1;
           Methanothermobacter thermautotrophicus str. Delta H|Rep:
           Cation efflux system protein - Methanobacterium
           thermoautotrophicum
          Length = 298

 Score = 37.5 bits (83), Expect = 0.69
 Identities = 67/306 (21%), Positives = 120/306 (39%), Gaps = 34/306 (11%)

Query: 106 RVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPD 165
           R     IG N             +GS +L +E  H+L+D +  +I   G     +  D  
Sbjct: 12  RAAFAGIGGNVLLTSLNFLVGISSGSVALVAEAAHTLSDVLTSVITYIGFRIGQRPPDRQ 71

Query: 166 HPYGYTNMRYVSSLISGVGIFCVGSGLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEG 225
           HPYG+     +  L+  V +F             GI+  + L + Y   F L  A     
Sbjct: 72  HPYGHGRAEALVGLV--VVVF------------LGIISYEILSEAYRKLF-LELAPPDYT 116

Query: 226 ATLMVALSAIRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAI---- 281
           A LM     I      AN+++  Y+ R  +   +  ++ D  A    +   SC+AI    
Sbjct: 117 AALMAGFGII------ANIAMTTYIRRIGERINSPAIVAD--AQHQKVDIFSCIAIMLGV 168

Query: 282 -SQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMI 340
              + G    D L ++++  ++   A  +   NV  ++G     E +++I         +
Sbjct: 169 AGSHLGLRFLDPLVAVIIAVLVLKTAFDVGRENVNNILGAVPSPEIMEDIEKSAMSVDGV 228

Query: 341 RAIHDVKGIDIGSNLIRYKAEVDFDGRALTR-SYLEKHDL-NALLEDMKKIDTIDDVETF 398
           + +H+V+ I+           ++ DG  + R ++   HD+   ++ED   ID I  V   
Sbjct: 229 KGLHEVR-INHFGPYASVDLHIEVDGDMMLRDAHRIAHDVERRVIED---IDIIKIVNVH 284

Query: 399 LLKHGE 404
           +   GE
Sbjct: 285 VCPVGE 290


>UniRef50_A5UNR6 Cluster: Heavy metal cation (Co/Zn/Cd) efflux
           system protein, CzcD family; n=1; Methanobrevibacter
           smithii ATCC 35061|Rep: Heavy metal cation (Co/Zn/Cd)
           efflux system protein, CzcD family - Methanobrevibacter
           smithii (strain PS / ATCC 35061 / DSM 861)
          Length = 299

 Score = 37.5 bits (83), Expect = 0.69
 Identities = 18/76 (23%), Positives = 41/76 (53%), Gaps = 1/76 (1%)

Query: 129 TGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCV 188
           T S ++ ++C+H L+DT++  +     H S +  + ++ YGY     + ++I+ + +  V
Sbjct: 38  TNSVAILADCLHDLSDTISIGLAGVLEHVSQKNPNENYTYGYQRFSILGAVITSIFVIIV 97

Query: 189 GSGLSFYHGVTGILDP 204
            S +  Y  ++ +L P
Sbjct: 98  -SVVVVYESISRLLCP 112


>UniRef50_Q08970 Cluster: Mitochondrial metal transporter 2,
           mitochondrial precursor; n=2; Saccharomyces
           cerevisiae|Rep: Mitochondrial metal transporter 2,
           mitochondrial precursor - Saccharomyces cerevisiae
           (Baker's yeast)
          Length = 449

 Score = 37.5 bits (83), Expect = 0.69
 Identities = 58/276 (21%), Positives = 111/276 (40%), Gaps = 19/276 (6%)

Query: 77  RRLRDYRREMSHTRSKDN----VEEVGLKTRSG-RVVLTAIGINGCNFLFKLCAWFYTGS 131
           + L  +    SHT   DN    +    +K   G R+    +  N    + K        S
Sbjct: 97  KSLLQHTHSHSHTHMHDNPLLSLNVQQIKKNPGVRITWIGLASNVGMAVGKFVGGITFHS 156

Query: 132 HSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGSG 191
            +L ++ +H+L+D V+  +  + +  + +    ++PYGY  +  V SL   V      +G
Sbjct: 157 QALLADSVHALSDLVSDFLTLFSVQYASRKPTSEYPYGYGKVETVGSL--AVSTILAMAG 214

Query: 192 LSF-YHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATL-MVALSAIRKGAREANMSLYEY 249
           +S  +  +  I+ P   H    +   L G   S   +L   A +         ++ + E+
Sbjct: 215 ISIGWSSLCAIVGPVIPHAILESMAGLIGETHSHSQSLTQQATNVNAVWIAAGSILVKEW 274

Query: 250 VMRSS-----DPSVNVVLL---EDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGTI 301
           V +++       + NV++             +VA   +  S +      D LG ++V  +
Sbjct: 275 VFQATKKVAIQTNSNVLMANAWHHRVDSLTSLVALVAITSSYFFNIQSLDNLGGLVVSGL 334

Query: 302 LGGVASFIILSNVGALVGRSIP--HEQLDEINSVLE 335
           +       ILS++  LV +SIP    +  EI SV++
Sbjct: 335 IIKTGGQGILSSLKELVDQSIPPTDPRYLEIESVIK 370


>UniRef50_UPI0000DAE7E5 Cluster: hypothetical protein
           Rgryl_01001288; n=1; Rickettsiella grylli|Rep:
           hypothetical protein Rgryl_01001288 - Rickettsiella
           grylli
          Length = 374

 Score = 37.1 bits (82), Expect = 0.91
 Identities = 42/225 (18%), Positives = 99/225 (44%), Gaps = 16/225 (7%)

Query: 131 SHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGS 190
           SH L ++ +HSL+D +  L++        + AD +HPYG+  +   ++++  + +  + +
Sbjct: 36  SHGLLADGVHSLSDLMVDLLVIIASKFGNKAADENHPYGHGRIETAATVLLAI-LLALAA 94

Query: 191 GLSFYHGVTGILDPQPLHDFYWAYFVLGGAVVSEGATLMVALSAIRKGAREANMSLYEYV 250
                + VT I     +H             +     L +ALS+I         + +  +
Sbjct: 95  LAIIVNAVTTI---HRIH----------VKEIPSQIVLWIALSSILLNELIYFWTKHIAI 141

Query: 251 MRSSDPSVNVVLLEDTAAVAGVIVAASCMAISQYTGNPLPDALGSILVGTILGGVASFII 310
              S+  ++      + + + + VA     +  + G P  DA+ +I+VG ++   A    
Sbjct: 142 QIKSNLLMSNAWHHRSDSFSSMAVAFG--VVGAWLGFPKLDAVAAIVVGLMILKTAWNFG 199

Query: 311 LSNVGALVGRSIPHEQLDEINSVLERDFMIRAIHDVKGIDIGSNL 355
             ++  LV  ++  E+ ++I   +++   ++AIH ++   I  ++
Sbjct: 200 WYSIRELVDTALSTEETEKIKRFIKKVSGVKAIHQLRTRSIAGSI 244


>UniRef50_Q8FU00 Cluster: Putative uncharacterized protein; n=1;
           Corynebacterium efficiens|Rep: Putative uncharacterized
           protein - Corynebacterium efficiens
          Length = 333

 Score = 37.1 bits (82), Expect = 0.91
 Identities = 18/69 (26%), Positives = 32/69 (46%)

Query: 131 SHSLFSECIHSLADTVNQLILAYGIHKSVQMADPDHPYGYTNMRYVSSLISGVGIFCVGS 190
           S ++ +  +  L   V  L    G+  + + A P HPYGY     ++ L+SG+ +   G 
Sbjct: 48  SQAMQAAWVQDLLGMVPPLAFLIGVKVARRRASPAHPYGYAQSMDIAHLVSGIALTAFGG 107

Query: 191 GLSFYHGVT 199
            L +   +T
Sbjct: 108 FLVYESTMT 116


>UniRef50_Q606W3 Cluster: Cation efflux family protein; n=2;
           Bacteria|Rep: Cation efflux family protein -
           Methylococcus capsulatus
          Length = 314

 Score = 37.1 bits (82), Expect = 0.91
 Identities = 59/252 (23%), Positives = 113/252 (44%), Gaps = 29/252 (11%)

Query: 105 GRVVLTAIGINGCNFLFKLCAWFYTGSHSLFSECIHSLADTVNQLILAYGIHKSVQMADP 164
           GR+V   I + G   +F+  A +   S +L ++ +H+L+D +   +  Y +  + Q A  
Sbjct: 19  GRLVWALI-LTGGFVVFEALAGWKANSLALLTDAVHNLSDVLALGLSWYAMRLTAQPAHA 77

Query: 165 DHPYGYTNMRYVSSLISGVGIFCVGSGL-SFYHGVTGILDPQPLHDFYWAYFVLGGAVVS 223
              +GY     +++L +  G+  VG  L   Y     +L P P+     A  ++G   V 
Sbjct: 78  AKTFGYHRAGILAALANSAGL--VGVALYILYDAYVRLLSPAPVQ----ADILIG---VG 128

Query: 224 EGATLMVALSA--IRKGAREANMSLYEYVMRSSDPSVNVVLLEDTAAVAGVIVAASCMAI 281
             A L+ A +A  +  G+ +      +  MRS+     + LL D  +  G I A   +AI
Sbjct: 129 GAALLVNAFTAWLVHHGSHD------DLNMRSA----FLHLLGDVVSTLGAIAAG--VAI 176

Query: 282 SQYTGNPLPDALGSILVGTILGGVASFIILSNVGALVGRSIPHEQLDEINSVLERDFMIR 341
            +YTG    D   S+L+  ++   A   +++ V  ++  S P +   ++ S++     + 
Sbjct: 177 -RYTGLYWLDPAVSVLIALLILWNAKG-LMAEVMDILLESTPRDV--DMGSMVRDMMQVE 232

Query: 342 AIHDVKGIDIGS 353
            +H V  + + S
Sbjct: 233 GVHGVHHLHVWS 244


  Database: uniref50
    Posted date:  Oct 5, 2007 11:19 AM
  Number of letters in database: 575,637,011
  Number of sequences in database:  1,657,284
  
Lambda     K      H
   0.322    0.139    0.405 

Gapped
Lambda     K      H
   0.279   0.0580    0.190 


Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 453,074,260
Number of Sequences: 1657284
Number of extensions: 18210965
Number of successful extensions: 50340
Number of sequences better than 10.0: 312
Number of HSP's better than 10.0 without gapping: 220
Number of HSP's successfully gapped in prelim test: 92
Number of HSP's that attempted gapping in prelim test: 49969
Number of HSP's gapped (non-prelim): 393
length of query: 436
length of database: 575,637,011
effective HSP length: 103
effective length of query: 333
effective length of database: 404,936,759
effective search space: 134843940747
effective search space used: 134843940747
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.9 bits)
S2: 74 (33.9 bits)

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